diff --git a/oba-base.owl b/oba-base.owl index 0f61ab01..42fab88b 100644 --- a/oba-base.owl +++ b/oba-base.owl @@ -2,6 +2,7 @@ - + A collection of biological attributes (traits) covering all kingdoms of life. Interoperable with VT (vertebrate trait ontology) and TO (plant trait ontology). Extends PATO. Ontology of Biological Attributes (OBA) - TermGenie 1.0 - 13:11:2015 10:21 oba 1.2 - foaf-homepage "http://wiki.geneontology.org/index.php/Extensions/x-attribute" xsd:anyURL - cjmungall - 2022-01-19 + 2022-08-03 @@ -51,6 +48,30 @@ + + + + oba + measured_in_taxon + true + Taxon in which a trait is usually measured. + measured_in_taxon + + + + + + + + oba + not_measured_in_taxon + true + Taxon in which a measurement is usually not taken. + not_measured_in_taxon + + + + @@ -61,6 +82,12 @@ + + + + + + @@ -71,12 +98,6 @@ - - - - - - @@ -89,12 +110,6 @@ - - - - - - @@ -173,26 +188,6 @@ - - - - - - - - - - - - - - - - shorthand - - - - @@ -224,53 +219,19 @@ - - - - BFO:0000050 - oba - part_of - part_of - - - - - - - - - BFO:0000051 - oba - has_part - has_part - + - - - - - - BFO:0000066 - oba - occurs_in - occurs_in - + - - - RO:0000052 - oba - inheres_in - inheres_in - + @@ -280,18 +241,9 @@ - + - - - - - - RO:0002314 - oba - inheres_in_part_of - inheres_in_part_of - + @@ -306,12 +258,78 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -354,6 +372,12 @@ + + + + + + @@ -390,6 +414,12 @@ + + + + + + @@ -432,6 +462,12 @@ + + + + + + @@ -456,12 +492,24 @@ + + + + + + + + + + + + @@ -540,6 +588,12 @@ + + + + + + @@ -552,6 +606,12 @@ + + + + + + @@ -564,6 +624,12 @@ + + + + + + @@ -612,6 +678,12 @@ + + + + + + @@ -768,12 +840,54 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -786,12 +900,24 @@ + + + + + + + + + + + + @@ -804,6 +930,12 @@ + + + + + + @@ -834,6 +966,12 @@ + + + + + + @@ -846,12 +984,36 @@ + + + + + + + + + + + + + + + + + + + + + + + + @@ -864,12 +1026,30 @@ + + + + + + + + + + + + + + + + + + @@ -894,12 +1074,24 @@ + + + + + + + + + + + + @@ -912,18 +1104,96 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -942,6 +1212,42 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -954,6 +1260,24 @@ + + + + + + + + + + + + + + + + + + @@ -972,18 +1296,84 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1002,6 +1392,42 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1014,12 +1440,66 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1032,24 +1512,72 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1062,6 +1590,48 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1080,18 +1650,180 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1110,24 +1842,84 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -2928,12 +3720,6 @@ - - - - - - @@ -3018,6 +3804,12 @@ + + + + + + @@ -4542,12 +5334,6 @@ - - - - - - @@ -6480,6 +7266,12 @@ + + + + + + @@ -7212,6 +8004,12 @@ + + + + + + @@ -7380,12 +8178,6 @@ - - - - - - @@ -7434,6 +8226,228 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -8130,12 +9144,6 @@ OBA:0000003 ER calcium ion concentration - - - - - true - @@ -8148,6 +9156,12 @@ endoplasmic reticulum calcium ion concentration of AUTO:patterns/patterns/entity_attribute_location + + + + + true + @@ -8580,14 +9594,14 @@ - + - The volume when measured in multicellular organism. - multicellular organism volume + The volume of a bodily fluid. + volume of bodily fluid oba OBA:0000036 body fluid levels @@ -8595,14 +9609,14 @@ - The volume when measured in multicellular organism. - AUTO:patterns/patterns/attribute_location + The volume of a bodily fluid. + AUTO:patterns/patterns/entity_attribute - multicellular organism volume - AUTO:patterns/patterns/attribute_location + volume of bodily fluid + AUTO:patterns/patterns/entity_attribute @@ -8610,11 +9624,7 @@ - - oba - OBA:0000037 - obsolete brood size true @@ -8623,11 +9633,7 @@ - - oba - OBA:0000039 - obsolete buoyancy true @@ -9171,8 +10177,8 @@ - The microvillus length of a ovarian follicle cell. - microvillus length of ovarian follicle cell + The microvillus length of a follicle cell of egg chamber. + microvillus length of follicle cell of egg chamber oba OBA:0000072 follicle cell microvillus length @@ -9180,13 +10186,13 @@ - The microvillus length of a ovarian follicle cell. + The microvillus length of a follicle cell of egg chamber. AUTO:patterns/patterns/entity_attribute - microvillus length of ovarian follicle cell + microvillus length of follicle cell of egg chamber AUTO:patterns/patterns/entity_attribute @@ -9195,10 +10201,7 @@ - - oba - OBA:0000074 true @@ -72461,20 +73464,20 @@ - The morphology of a pericyte cell. - morphology of pericyte cell - pericyte cell morphology + The morphology of a pericyte. + morphology of pericyte + pericyte morphology - The morphology of a pericyte cell. + The morphology of a pericyte. AUTO:patterns/patterns/entity_attribute - morphology of pericyte cell + morphology of pericyte AUTO:patterns/patterns/entity_attribute @@ -85728,25 +86731,25 @@ - + - The onset quality of a cell aging. - onset quality of cell aging - cell aging onset quality + The onset quality of a cellular senescence. + onset quality of cellular senescence + cellular senescence onset quality - The onset quality of a cell aging. + The onset quality of a cellular senescence. AUTO:patterns/patterns/entity_attribute - onset quality of cell aging + onset quality of cellular senescence AUTO:patterns/patterns/entity_attribute @@ -86987,20 +87990,20 @@ - The amount of a glomerular visceral epithelial cell. - amount of glomerular visceral epithelial cell - glomerular visceral epithelial cell amount + The amount of a podocyte. + amount of podocyte + podocyte amount - The amount of a glomerular visceral epithelial cell. + The amount of a podocyte. AUTO:patterns/patterns/entity_attribute - amount of glomerular visceral epithelial cell + amount of podocyte AUTO:patterns/patterns/entity_attribute @@ -124802,20 +125805,20 @@ - The morphology of a visceral layer of glomerular capsule. - morphology of visceral layer of glomerular capsule - visceral layer of glomerular capsule morphology + The morphology of a glomerular visceral epithelium. + morphology of glomerular visceral epithelium + glomerular visceral epithelium morphology - The morphology of a visceral layer of glomerular capsule. + The morphology of a glomerular visceral epithelium. AUTO:patterns/patterns/entity_attribute - morphology of visceral layer of glomerular capsule + morphology of glomerular visceral epithelium AUTO:patterns/patterns/entity_attribute @@ -126909,25 +127912,25 @@ - + - The displaced of a obsolete neuron of cerebral cortex. - displaced of obsolete neuron of cerebral cortex - obsolete neuron of cerebral cortex displaced + The displaced of a cerebral cortex neuron. + displaced of cerebral cortex neuron + cerebral cortex neuron displaced - The displaced of a obsolete neuron of cerebral cortex. + The displaced of a cerebral cortex neuron. AUTO:patterns/patterns/entity_attribute - displaced of obsolete neuron of cerebral cortex + displaced of cerebral cortex neuron AUTO:patterns/patterns/entity_attribute @@ -159673,20 +160676,20 @@ - The quality of a chromosome breakage. - quality of chromosome breakage - chromosome breakage quality + The quality of a programmed DNA elimination by chromosome breakage. + quality of programmed DNA elimination by chromosome breakage + programmed DNA elimination by chromosome breakage quality - The quality of a chromosome breakage. + The quality of a programmed DNA elimination by chromosome breakage. AUTO:patterns/patterns/entity_attribute - quality of chromosome breakage + quality of programmed DNA elimination by chromosome breakage AUTO:patterns/patterns/entity_attribute @@ -172568,33 +173571,9 @@ - - - - - - - - - - - - The quality of a subarachnoid space development. - quality of subarachnoid space development - subarachnoid space development quality + Reason for obsoletion: [This term was obsoleted because it does not represent a real process. While subarachnoid space is a valid anatomical structure, it is formed by the development of the structures that surround it.](https://www.ebi.ac.uk/QuickGO/term/GO:1903374) + true - - - - The quality of a subarachnoid space development. - AUTO:patterns/patterns/entity_attribute - - - - - quality of subarachnoid space development - AUTO:patterns/patterns/entity_attribute - @@ -173536,20 +174515,20 @@ - The quality of a glomerular visceral epithelial cell. - quality of glomerular visceral epithelial cell - glomerular visceral epithelial cell quality + The quality of a podocyte. + quality of podocyte + podocyte quality - The quality of a glomerular visceral epithelial cell. + The quality of a podocyte. AUTO:patterns/patterns/entity_attribute - quality of glomerular visceral epithelial cell + quality of podocyte AUTO:patterns/patterns/entity_attribute @@ -178062,20 +179041,20 @@ - The amount of vitamin (role). - amount of vitamin (role) - vitamin (role) amount + The amount of vitamin. + amount of vitamin + vitamin amount - The amount of vitamin (role). + The amount of vitamin. AUTO:patterns/patterns/chemical_role_attribute - amount of vitamin (role) + amount of vitamin AUTO:patterns/patterns/chemical_role_attribute @@ -179107,7 +180086,7 @@ The amount of a tumor necrosis factor. amount of tumor necrosis factor - tumor necrosis factor amount + tumor necrosis factor alpha amount @@ -179838,1169 +180817,7066 @@ - + + + + + + + + + + + + + + + The morphology of a embryonic cloacal fold. + morphology of embryonic cloacal fold + embryonic cloacal fold morphology + + + + + The morphology of a embryonic cloacal fold. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of embryonic cloacal fold + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a parotid gland myoepithelium. + morphology of parotid gland myoepithelium + parotid gland myoepithelium morphology + + + + + The morphology of a parotid gland myoepithelium. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of parotid gland myoepithelium + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a excitatory synapse. + morphology of excitatory synapse + excitatory synapse morphology + + + + + The morphology of a excitatory synapse. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of excitatory synapse + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a polar trophectoderm. + morphology of polar trophectoderm + polar trophectoderm morphology + + + + + The morphology of a polar trophectoderm. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of polar trophectoderm + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a germ layer. + morphology of germ layer + germ layer morphology + + + + + The morphology of a germ layer. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of germ layer + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a mesoderm. + morphology of mesoderm + mesoderm morphology + + + + + The morphology of a mesoderm. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of mesoderm + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a hemotrichorial placental membrane. + morphology of hemotrichorial placental membrane + hemotrichorial placental membrane morphology + + + + + The morphology of a hemotrichorial placental membrane. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of hemotrichorial placental membrane + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a platelet alpha granule. + morphology of platelet alpha granule + platelet alpha granule morphology + + + + + The morphology of a platelet alpha granule. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of platelet alpha granule + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a extraembryonic mesoderm. + morphology of extraembryonic mesoderm + extraembryonic mesoderm morphology + + + + + The morphology of a extraembryonic mesoderm. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of extraembryonic mesoderm + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a cell. + morphology of cell + cell morphology + + + + + The morphology of a cell. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of cell + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a melanophage. + morphology of melanophage + melanophage morphology + + + + + The morphology of a melanophage. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of melanophage + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a costotransverse joint. + morphology of costotransverse joint + costotransverse joint morphology + + + + + The morphology of a costotransverse joint. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of costotransverse joint + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a symmetric synapse. + morphology of symmetric synapse + symmetric synapse morphology + + + + + The morphology of a symmetric synapse. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of symmetric synapse + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a rhombomere boundary. + morphology of rhombomere boundary + rhombomere boundary morphology + + + + + The morphology of a rhombomere boundary. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of rhombomere boundary + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a asymmetric synapse. + morphology of asymmetric synapse + asymmetric synapse morphology + + + + + The morphology of a asymmetric synapse. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of asymmetric synapse + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a ribbon synapse. + morphology of ribbon synapse + ribbon synapse morphology + + + + + The morphology of a ribbon synapse. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of ribbon synapse + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a urachus. + morphology of urachus + urachus morphology + + + + + The morphology of a urachus. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of urachus + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a endoderm. + morphology of endoderm + endoderm morphology + + + + + The morphology of a endoderm. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of endoderm + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a uncondensed odontogenic mesenchyme. + morphology of uncondensed odontogenic mesenchyme + uncondensed odontogenic mesenchyme morphology + + + + + The morphology of a uncondensed odontogenic mesenchyme. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of uncondensed odontogenic mesenchyme + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a embryo. + morphology of embryo + embryo morphology + + + + + The morphology of a embryo. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of embryo + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a lamina terminalis of neural tube. + morphology of lamina terminalis of neural tube + lamina terminalis of neural tube morphology + + + + + The morphology of a lamina terminalis of neural tube. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of lamina terminalis of neural tube + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a beige adipocyte. + morphology of beige adipocyte + beige adipocyte morphology + + + + + The morphology of a beige adipocyte. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of beige adipocyte + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a inhibitory synapse. + morphology of inhibitory synapse + inhibitory synapse morphology + + + + + The morphology of a inhibitory synapse. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of inhibitory synapse + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a joint of rib. + morphology of joint of rib + joint of rib morphology + + + + + The morphology of a joint of rib. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of joint of rib + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a blastocyst. + morphology of blastocyst + blastocyst morphology + + + + + The morphology of a blastocyst. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of blastocyst + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a costovertebral joint. + morphology of costovertebral joint + costovertebral joint morphology + + + + + The morphology of a costovertebral joint. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of costovertebral joint + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The morphology of a circle of Willis. + morphology of circle of Willis + circle of Willis morphology + + + + + The morphology of a circle of Willis. + AUTO:patterns/patterns/entity_attribute + + + + + morphology of circle of Willis + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The osmolality of a feces. + osmolality of feces + feces osmolality + + + + + The osmolality of a feces. + AUTO:patterns/patterns/entity_attribute + + + + + osmolality of feces + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The circumference of a abdominal segment of trunk. + circumference of abdominal segment of trunk + waist circumference + + + + + The circumference of a abdominal segment of trunk. + AUTO:patterns/patterns/entity_attribute + + + + + circumference of abdominal segment of trunk + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The duration of a http://purl.obolibrary.org/obo/EFO_0005054. + duration of http://purl.obolibrary.org/obo/EFO_0005054 + QRS duration + + + + + The duration of a http://purl.obolibrary.org/obo/EFO_0005054. + AUTO:patterns/patterns/entity_attribute + + + + + duration of http://purl.obolibrary.org/obo/EFO_0005054 + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The rate of a heart contraction. + rate of heart contraction + heart rate + + + + + The rate of a heart contraction. + AUTO:patterns/patterns/entity_attribute + + + + + rate of heart contraction + AUTO:patterns/patterns/entity_attribute + + + + + + + + oba + OBA:1001088 + obsolete race + true + + + + + + + + + + + + + + + + + + + The biological sex of a multicellular organism. + biological sex of multicellular organism + multicellular organism sex + + + + + The biological sex of a multicellular organism. + AUTO:patterns/patterns/entity_attribute + + + + + biological sex of multicellular organism + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The color of a feather. + color of feather + feather color + + + + + The color of a feather. + AUTO:patterns/patterns/entity_attribute + + + + + color of feather + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The quality of a eggshell. + quality of eggshell + egg shell trait + + + + + The quality of a eggshell. + AUTO:patterns/patterns/entity_attribute + + + + + quality of eggshell + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The color of a eggshell. + color of eggshell + egg shell color + + + + + The color of a eggshell. + AUTO:patterns/patterns/entity_attribute + + + + + color of eggshell + AUTO:patterns/patterns/entity_attribute + + + + + + + + + + + + + + + + + + + The age at which Alzheimer disease manifestations first appear. + age Alzheimer disease symptoms begin + age at onset of Alzheimer disease + age of onset of Alzheimer disease + + + + + + + + + + + + + + + + + + + The age at which asthma manifestations first appear. + age asthma symptoms begin + age at onset of asthma + age of onset of asthma + + + + + + + + + + + + + + + + + + + The age at which urinary bladder carcinoma manifestations first appear. + age at onset of urinary bladder carcinoma + age urinary bladder carcinoma symptoms begin + age of onset of urinary bladder carcinoma + + + + + + + + + + + + + + + + + + + The age at which cataract manifestations first appear. + age at onset of cataract + age cataract symptoms begin + age of onset of cataract + + + + + + + + + + + + + + + + + + + The age at which hyperlipidemia manifestations first appear. + age at onset of hyperlipidemia + age hyperlipidemia symptoms begin + age of onset of hyperlipidemia + + + + + + + + + + + + + + + + + + + The age at which osteoarthritis manifestations first appear. + age at onset of osteoarthritis + age osteoarthritis symptoms begin + age of onset of osteoarthritis + + + + + + + + + + + + + + + + + + + The age at which Parkinson disease manifestations first appear. + age Parkinson disease symptoms begin + age at onset of Parkinson disease + age of onset of Parkinson disease + + + + + + + + + + + + + + + + + + + The age at which essential hypertension manifestations first appear. + age at onset of essential hypertension + age essential hypertension symptoms begin + age of onset of essential hypertension + + + + + + + + + + + + + + + + + + + The age at which schizophrenia manifestations first appear. + age at onset of schizophrenia + age schizophrenia symptoms begin + age of onset of schizophrenia + + + + + + + + + + + + + + + + + + + The age at which type 1 diabetes mellitus manifestations first appear. + age at onset of type 1 diabetes mellitus + age type 1 diabetes mellitus symptoms begin + age of onset of type 1 diabetes mellitus + + + + + + + + + + + + + + + + + + + The age at which type 2 diabetes mellitus manifestations first appear. + age at onset of type 2 diabetes mellitus + age type 2 diabetes mellitus symptoms begin + age of onset of type 2 diabetes mellitus + + + + + + + + + + + + + + + + + + + The age at which childhood onset asthma manifestations first appear. + age at onset of childhood onset asthma + age childhood onset asthma symptoms begin + age of onset of childhood onset asthma + + + + + + + + + + + + + + + + + + + The age at which alcohol dependence manifestations first appear. + age alcohol dependence symptoms begin + age at onset of alcohol dependence + age of onset of alcohol dependence + + + + + + + + + + + + + + + + + + + The age at which allergic disease manifestations first appear. + age allergic disease symptoms begin + age at onset of allergic disease + age of onset of allergic disease + + + + + + + + + + + + + + + + + + + The age at which amyotrophic lateral sclerosis manifestations first appear. + age amyotrophic lateral sclerosis symptoms begin + age at onset of amyotrophic lateral sclerosis + age of onset of amyotrophic lateral sclerosis + + + + + + + + + + + + + + + + + + + The age at which bipolar disorder manifestations first appear. + age at onset of bipolar disorder + age bipolar disorder symptoms begin + age of onset of bipolar disorder + + + + + + + + + + + + + + + + + + + The age at which Buruli ulcer disease manifestations first appear. + age Buruli ulcer disease symptoms begin + age at onset of Buruli ulcer disease + age of onset of Buruli ulcer disease + + + + + + + + + + + + + + + + + + + The age at which frontotemporal dementia manifestations first appear. + age at onset of frontotemporal dementia + age frontotemporal dementia symptoms begin + age of onset of frontotemporal dementia + + + + + + + + + + + + + + + + + + + The age at which Huntington disease manifestations first appear. + age Huntington disease symptoms begin + age at onset of Huntington disease + age of onset of Huntington disease + + + + + + + + + + + + + + + + + + + The age at which migraine disorder manifestations first appear. + age at onset of migraine disorder + age migraine disorder symptoms begin + age of onset of migraine disorder + + + + + + + + + + + + + + + + + + + The age at which migraine with aura manifestations first appear. + age at onset of migraine with aura + age migraine with aura symptoms begin + age of onset of migraine with aura + + + + + + + + + + + + + + + + + + + The age at which migraine without aura manifestations first appear. + age at onset of migraine without aura + age migraine without aura symptoms begin + age of onset of migraine without aura + + + + + + + + + + + + + + + + + + + The age at which multiple sclerosis manifestations first appear. + age at onset of multiple sclerosis + age multiple sclerosis symptoms begin + age of onset of multiple sclerosis + + + + + + + + + + + + + + + + + + + The age at which myopia manifestations first appear. + age at onset of myopia + age myopia symptoms begin + age of onset of myopia + + + + + + + + + + + + + + + + + + + The age at which refractive error manifestations first appear. + age at onset of refractive error + age refractive error symptoms begin + age of onset of refractive error + + + + + + + + + + + + + + + + + + + The age at which narcolepsy-cataplexy syndrome manifestations first appear. + age at onset of narcolepsy-cataplexy syndrome + age narcolepsy-cataplexy syndrome symptoms begin + age of onset of narcolepsy-cataplexy syndrome + + + + + + + + + + + + + + + + + + + The age at which coronary atherosclerosis manifestations first appear. + age at onset of coronary atherosclerosis + age coronary atherosclerosis symptoms begin + age of onset of coronary atherosclerosis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with warfarin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to warfarin trait + trait in response to warfarin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with zileuton. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to zileuton trait + trait in response to zileuton + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with ziprasidone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to ziprasidone trait + trait in response to ziprasidone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with zonisamide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to zonisamide trait + trait in response to zonisamide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with erlotinib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to erlotinib trait + trait in response to erlotinib + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with efavirenz. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to efavirenz trait + trait in response to efavirenz + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with radiosensitizing agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to radiosensitizing agent trait + trait in response to radiosensitizing agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tafenoquine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tafenoquine trait + trait in response to tafenoquine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with migalastat. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to migalastat trait + trait in response to migalastat + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with endocrine disruptor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to endocrine disruptor trait + trait in response to endocrine disruptor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with acetylsalicylic acid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to acetylsalicylic acid trait + trait in response to acetylsalicylic acid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with mycophenolic acid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to mycophenolic acid trait + trait in response to mycophenolic acid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with morphine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to morphine trait + trait in response to morphine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with gemcitabine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to gemcitabine trait + trait in response to gemcitabine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with vitamin B3. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to vitamin B3 trait + trait in response to vitamin B3 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with bleomycin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to bleomycin trait + trait in response to bleomycin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with drug. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to drug trait + trait in response to drug + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with glucocorticoid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to glucocorticoid trait + trait in response to glucocorticoid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with isoquinoline alkaloid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to isoquinoline alkaloid trait + trait in response to isoquinoline alkaloid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with camptothecin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to camptothecin trait + trait in response to camptothecin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with cisplatin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to cisplatin trait + trait in response to cisplatin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with vancomycin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to vancomycin trait + trait in response to vancomycin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with rifampicin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to rifampicin trait + trait in response to rifampicin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with heparin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to heparin trait + trait in response to heparin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with vincristine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to vincristine trait + trait in response to vincristine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with cytarabine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to cytarabine trait + trait in response to cytarabine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with doxorubicin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to doxorubicin trait + trait in response to doxorubicin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with serotonin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to serotonin trait + trait in response to serotonin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with melphalan. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to melphalan trait + trait in response to melphalan + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with silicon dioxide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to silicon dioxide trait + trait in response to silicon dioxide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with ethanol. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to ethanol trait + trait in response to ethanol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with aripiprazole. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to aripiprazole trait + trait in response to aripiprazole + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with carboplatin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to carboplatin trait + trait in response to carboplatin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with bupropion. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to bupropion trait + trait in response to bupropion + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with buspirone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to buspirone trait + trait in response to buspirone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with vitamin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to vitamin trait + trait in response to vitamin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antimicrobial agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antimicrobial agent trait + trait in response to antimicrobial agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with platinum. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to platinum trait + trait in response to platinum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with candesartan. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to candesartan trait + trait in response to candesartan + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with carbamazepine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to carbamazepine trait + trait in response to carbamazepine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antimetabolite. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antimetabolite trait + trait in response to antimetabolite + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with fatty acid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to fatty acid trait + trait in response to fatty acid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor trait + trait in response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antidepressant. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antidepressant trait + trait in response to antidepressant + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with non-steroidal anti-inflammatory drug. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to non-steroidal anti-inflammatory drug trait + trait in response to non-steroidal anti-inflammatory drug + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antipsychotic agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antipsychotic agent trait + trait in response to antipsychotic agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with diuretic. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to diuretic trait + trait in response to diuretic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with bronchodilator agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to bronchodilator agent trait + trait in response to bronchodilator agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with beta-adrenergic antagonist. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to beta-adrenergic antagonist trait + trait in response to beta-adrenergic antagonist + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antineoplastic agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antineoplastic agent trait + trait in response to antineoplastic agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with anticonvulsant. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to anticonvulsant trait + trait in response to anticonvulsant + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with thiopurine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to thiopurine trait + trait in response to thiopurine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with immunosuppressive agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to immunosuppressive agent trait + trait in response to immunosuppressive agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with antiviral drug. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to antiviral drug trait + trait in response to antiviral drug + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with taxane. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to taxane trait + trait in response to taxane + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with escitalopram. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to escitalopram trait + trait in response to escitalopram + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with duloxetine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to duloxetine trait + trait in response to duloxetine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with citalopram. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to citalopram trait + trait in response to citalopram + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with clozapine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to clozapine trait + trait in response to clozapine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with protease inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to protease inhibitor trait + trait in response to protease inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with EC 3.1.1.8 (cholinesterase) inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to EC 3.1.1.8 (cholinesterase) inhibitor trait + trait in response to EC 3.1.1.8 (cholinesterase) inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with growth hormone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to growth hormone trait + trait in response to growth hormone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with clopidogrel. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to clopidogrel trait + trait in response to clopidogrel + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with calcium channel blocker. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to calcium channel blocker trait + trait in response to calcium channel blocker + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tyrosine kinase inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tyrosine kinase inhibitor trait + trait in response to tyrosine kinase inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with atorvastatin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to atorvastatin trait + trait in response to atorvastatin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with cyclophosphamide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to cyclophosphamide trait + trait in response to cyclophosphamide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with allopurinol. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to allopurinol trait + trait in response to allopurinol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with cyclosporin A. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to cyclosporin A trait + trait in response to cyclosporin A + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tamoxifen. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tamoxifen trait + trait in response to tamoxifen + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with dexamethasone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to dexamethasone trait + trait in response to dexamethasone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with abacavir. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to abacavir trait + trait in response to abacavir + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with methotrexate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to methotrexate trait + trait in response to methotrexate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with paclitaxel. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to paclitaxel trait + trait in response to paclitaxel + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with 5-fluorouracil. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to 5-fluorouracil trait + trait in response to 5-fluorouracil + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with diclofenac. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to diclofenac trait + trait in response to diclofenac + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with etoposide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to etoposide trait + trait in response to etoposide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor trait + trait in response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with lapatinib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to lapatinib trait + trait in response to lapatinib + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with gefitinib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to gefitinib trait + trait in response to gefitinib + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with lithium(1+). + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to lithium(1+) trait + trait in response to lithium(1+) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with fenofibrate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to fenofibrate trait + trait in response to fenofibrate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with anticoagulant. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to anticoagulant trait + trait in response to anticoagulant + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with thiazide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to thiazide trait + trait in response to thiazide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with platelet aggregation inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to platelet aggregation inhibitor trait + trait in response to platelet aggregation inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with mercaptopurine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to mercaptopurine trait + trait in response to mercaptopurine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with montelukast. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to montelukast trait + trait in response to montelukast + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with EC 1.14.14.14 (aromatase) inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to EC 1.14.14.14 (aromatase) inhibitor trait + trait in response to EC 1.14.14.14 (aromatase) inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with corticosteroid. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to corticosteroid trait + trait in response to corticosteroid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tetracyclic antidepressant. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tetracyclic antidepressant trait + trait in response to tetracyclic antidepressant + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with serotonin uptake inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to serotonin uptake inhibitor trait + trait in response to serotonin uptake inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with bortezomib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to bortezomib trait + trait in response to bortezomib + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with haloperidol. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to haloperidol trait + trait in response to haloperidol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with hydrochlorothiazide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to hydrochlorothiazide trait + trait in response to hydrochlorothiazide + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor trait + trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with opioid agent. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to opioid agent trait + trait in response to opioid agent + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with floxuridine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to floxuridine trait + trait in response to floxuridine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with angiotensin receptor antagonist. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to angiotensin receptor antagonist trait + trait in response to angiotensin receptor antagonist + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tacrolimus hydrate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tacrolimus hydrate trait + trait in response to tacrolimus hydrate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with metamizole. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to metamizole trait + trait in response to metamizole + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with ribavirin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to ribavirin trait + trait in response to ribavirin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with stavudine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to stavudine trait + trait in response to stavudine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with sotalol. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to sotalol trait + trait in response to sotalol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tenofovir (anhydrous). + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tenofovir (anhydrous) trait + trait in response to tenofovir (anhydrous) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with lamotrigine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to lamotrigine trait + trait in response to lamotrigine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with amisulpride. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to amisulpride trait + trait in response to amisulpride + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with ximelagatran. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to ximelagatran trait + trait in response to ximelagatran + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with iloperidone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to iloperidone trait + trait in response to iloperidone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with losartan. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to losartan trait + trait in response to losartan + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with ivacaftor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to ivacaftor trait + trait in response to ivacaftor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with metformin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to metformin trait + trait in response to metformin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with mTOR inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to mTOR inhibitor trait + trait in response to mTOR inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with methylphenidate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to methylphenidate trait + trait in response to methylphenidate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with topoisomerase inhibitor. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to topoisomerase inhibitor trait + trait in response to topoisomerase inhibitor + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with dabigatran etexilate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to dabigatran etexilate trait + trait in response to dabigatran etexilate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with omacetaxine mepesuccinate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to omacetaxine mepesuccinate trait + trait in response to omacetaxine mepesuccinate + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with tofacitinib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tofacitinib trait + trait in response to tofacitinib + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A trait that affects the response to a stimulus with pazopanib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to pazopanib trait + trait in response to pazopanib + + + + + - + - + - + + + + + + + + + + + - The morphology of a embryonic cloacal fold. - morphology of embryonic cloacal fold - embryonic cloacal fold morphology + A trait that affects the response to a stimulus with nitrofurantoin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to nitrofurantoin trait + trait in response to nitrofurantoin - - - - The morphology of a embryonic cloacal fold. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of embryonic cloacal fold - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a parotid gland myoepithelium. - morphology of parotid gland myoepithelium - parotid gland myoepithelium morphology + A trait that affects the response to a stimulus with triamcinolone acetonide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to triamcinolone acetonide trait + trait in response to triamcinolone acetonide - - - - The morphology of a parotid gland myoepithelium. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of parotid gland myoepithelium - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a excitatory synapse. - morphology of excitatory synapse - excitatory synapse morphology + A trait that affects the response to a stimulus with temozolomide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to temozolomide trait + trait in response to temozolomide - - - - The morphology of a excitatory synapse. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of excitatory synapse - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a polar trophectoderm. - morphology of polar trophectoderm - polar trophectoderm morphology + A trait that affects the response to a stimulus with dabrafenib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to dabrafenib trait + trait in response to dabrafenib - - - - The morphology of a polar trophectoderm. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of polar trophectoderm - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a germ layer. - morphology of germ layer - germ layer morphology + A trait that affects the response to a stimulus with trametinib. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to trametinib trait + trait in response to trametinib - - - - The morphology of a germ layer. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of germ layer - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a mesoderm. - morphology of mesoderm - mesoderm morphology + A trait that affects the response to a stimulus with dimethyl fumarate. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to dimethyl fumarate trait + trait in response to dimethyl fumarate - - - - The morphology of a mesoderm. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of mesoderm - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a hemotrichorial placental membrane. - morphology of hemotrichorial placental membrane - hemotrichorial placental membrane morphology + A trait that affects the response to a stimulus with dolutegravir. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to dolutegravir trait + trait in response to dolutegravir - - - - The morphology of a hemotrichorial placental membrane. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of hemotrichorial placental membrane - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a platelet alpha granule. - morphology of platelet alpha granule - platelet alpha granule morphology + A trait that affects the response to a stimulus with olanzapine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to olanzapine trait + trait in response to olanzapine - - - - The morphology of a platelet alpha granule. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of platelet alpha granule - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a extraembryonic mesoderm. - morphology of extraembryonic mesoderm - extraembryonic mesoderm morphology + A trait that affects the response to a stimulus with oxcarbazepine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to oxcarbazepine trait + trait in response to oxcarbazepine - - - - The morphology of a extraembryonic mesoderm. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of extraembryonic mesoderm - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a cell. - morphology of cell - cell morphology + A trait that affects the response to a stimulus with perphenazine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to perphenazine trait + trait in response to perphenazine - - - - The morphology of a cell. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of cell - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a melanophage. - morphology of melanophage - melanophage morphology + A trait that affects the response to a stimulus with irinotecan. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to irinotecan trait + trait in response to irinotecan - - - - The morphology of a melanophage. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of melanophage - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a costotransverse joint. - morphology of costotransverse joint - costotransverse joint morphology + A trait that affects the response to a stimulus with phenylephrine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to phenylephrine trait + trait in response to phenylephrine - - - - The morphology of a costotransverse joint. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of costotransverse joint - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a symmetric synapse. - morphology of symmetric synapse - symmetric synapse morphology + A trait that affects the response to a stimulus with phenytoin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to phenytoin trait + trait in response to phenytoin - - - - The morphology of a symmetric synapse. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of symmetric synapse - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a rhombomere boundary. - morphology of rhombomere boundary - rhombomere boundary morphology + A trait that affects the response to a stimulus with 4-(4-Hydroxyphenyl)-2-butanol. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to 4-(4-Hydroxyphenyl)-2-butanol trait + trait in response to 4-(4-Hydroxyphenyl)-2-butanol - - - - The morphology of a rhombomere boundary. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of rhombomere boundary - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a asymmetric synapse. - morphology of asymmetric synapse - asymmetric synapse morphology + A trait that affects the response to a stimulus with paliperidone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to paliperidone trait + trait in response to paliperidone - - - - The morphology of a asymmetric synapse. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of asymmetric synapse - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a ribbon synapse. - morphology of ribbon synapse - ribbon synapse morphology + A trait that affects the response to a stimulus with prednisolone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to prednisolone trait + trait in response to prednisolone - - - - The morphology of a ribbon synapse. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of ribbon synapse - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a urachus. - morphology of urachus - urachus morphology + A trait that affects the response to a stimulus with quetiapine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to quetiapine trait + trait in response to quetiapine - - - - The morphology of a urachus. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of urachus - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a endoderm. - morphology of endoderm - endoderm morphology + A trait that affects the response to a stimulus with risperidone. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to risperidone trait + trait in response to risperidone - - - - The morphology of a endoderm. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of endoderm - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a uncondensed odontogenic mesenchyme. - morphology of uncondensed odontogenic mesenchyme - uncondensed odontogenic mesenchyme morphology + A trait that affects the response to a stimulus with simvastatin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to simvastatin trait + trait in response to simvastatin - - - - The morphology of a uncondensed odontogenic mesenchyme. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of uncondensed odontogenic mesenchyme - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a embryo. - morphology of embryo - embryo morphology + A trait that affects the response to a stimulus with sulfasalazine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to sulfasalazine trait + trait in response to sulfasalazine - - - - The morphology of a embryo. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of embryo - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a lamina terminalis of neural tube. - morphology of lamina terminalis of neural tube - lamina terminalis of neural tube morphology + A trait that affects the response to a stimulus with tamsulosin. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to tamsulosin trait + trait in response to tamsulosin - - - - The morphology of a lamina terminalis of neural tube. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of lamina terminalis of neural tube - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a beige adipocyte. - morphology of beige adipocyte - beige adipocyte morphology + A trait that affects the response to a stimulus with terbinafine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to terbinafine trait + trait in response to terbinafine - - - - The morphology of a beige adipocyte. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of beige adipocyte - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a inhibitory synapse. - morphology of inhibitory synapse - inhibitory synapse morphology + A trait that affects the response to a stimulus with Triptolide. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to Triptolide trait + trait in response to Triptolide - - - - The morphology of a inhibitory synapse. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of inhibitory synapse - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The morphology of a joint of rib. - morphology of joint of rib - joint of rib morphology + A trait that affects the response to a stimulus with venlafaxine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to venlafaxine trait + trait in response to venlafaxine - - - - The morphology of a joint of rib. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of joint of rib - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The morphology of a blastocyst. - morphology of blastocyst - blastocyst morphology + The age at which cancer manifestations first appear. + age at onset of cancer + age cancer symptoms begin + age of onset of cancer - - - - The morphology of a blastocyst. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of blastocyst - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The morphology of a costovertebral joint. - morphology of costovertebral joint - costovertebral joint morphology + The age at which glaucoma manifestations first appear. + age at onset of glaucoma + age glaucoma symptoms begin + age of onset of glaucoma - - - - The morphology of a costovertebral joint. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of costovertebral joint - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The morphology of a circle of Willis. - morphology of circle of Willis - circle of Willis morphology + The age at which stroke disorder manifestations first appear. + age at onset of stroke disorder + age stroke disorder symptoms begin + age of onset of stroke disorder - - - - The morphology of a circle of Willis. - AUTO:patterns/patterns/entity_attribute - - - - - morphology of circle of Willis - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The osmolality of a feces. - osmolality of feces - feces osmolality + The age at which coronary stenosis manifestations first appear. + age at onset of coronary stenosis + age coronary stenosis symptoms begin + age of onset of coronary stenosis - - - - The osmolality of a feces. - AUTO:patterns/patterns/entity_attribute - - - - - osmolality of feces - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The circumference of a abdominal segment of trunk. - circumference of abdominal segment of trunk - waist circumference + The age at which glioblastoma manifestations first appear. + age at onset of glioblastoma + age glioblastoma symptoms begin + age of onset of glioblastoma - - - - The circumference of a abdominal segment of trunk. - AUTO:patterns/patterns/entity_attribute - - - - - circumference of abdominal segment of trunk - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The duration of a http://purl.obolibrary.org/obo/EFO_0005054. - duration of http://purl.obolibrary.org/obo/EFO_0005054 - QRS duration + The age at which systemic lupus erythematosus manifestations first appear. + age at onset of systemic lupus erythematosus + age systemic lupus erythematosus symptoms begin + age of onset of systemic lupus erythematosus - - - - The duration of a http://purl.obolibrary.org/obo/EFO_0005054. - AUTO:patterns/patterns/entity_attribute - - - - - duration of http://purl.obolibrary.org/obo/EFO_0005054 - AUTO:patterns/patterns/entity_attribute - - + - + - + - + - The rate of a heart contraction. - rate of heart contraction - heart rate + The age at which hypertensive disorder manifestations first appear. + age at onset of hypertensive disorder + age hypertensive disorder symptoms begin + age of onset of hypertensive disorder - - - - The rate of a heart contraction. - AUTO:patterns/patterns/entity_attribute - - - - - rate of heart contraction - AUTO:patterns/patterns/entity_attribute - - + - - oba - OBA:1001088 - obsolete race - true + + + + + + + + + + + + + The age at which Machado-Joseph disease manifestations first appear. + age Machado-Joseph disease symptoms begin + age at onset of Machado-Joseph disease + age of onset of Machado-Joseph disease - + - + - + - + - The biological sex of a multicellular organism. - biological sex of multicellular organism - multicellular organism sex + The age at which major depressive disorder manifestations first appear. + age at onset of major depressive disorder + age major depressive disorder symptoms begin + age of onset of major depressive disorder - - - - The biological sex of a multicellular organism. - AUTO:patterns/patterns/entity_attribute - - - - - biological sex of multicellular organism - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The color of a feather. - color of feather - feather color + A trait that affects the response to a stimulus with methamphetamine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to methamphetamine trait + trait in response to methamphetamine - - - - The color of a feather. - AUTO:patterns/patterns/entity_attribute - - - - - color of feather - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The quality of a eggshell. - quality of eggshell - egg shell trait + A trait that affects the response to a stimulus with cocaine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to cocaine trait + trait in response to cocaine - - - - The quality of a eggshell. - AUTO:patterns/patterns/entity_attribute - - - - - quality of eggshell - AUTO:patterns/patterns/entity_attribute - - + - + - + - + + + + + + + + + + + - The color of a eggshell. - color of eggshell - egg shell color + A trait that affects the response to a stimulus with nicotine. + https://orcid.org/0000-0001-8314-2140 + https://orcid.org/0000-0002-7073-9172 + response to nicotine trait + trait in response to nicotine - - - - The color of a eggshell. - AUTO:patterns/patterns/entity_attribute - - - - - color of eggshell - AUTO:patterns/patterns/entity_attribute - @@ -230883,20 +237759,20 @@ - The morphology of a glomerular visceral epithelial cell. - morphology of glomerular visceral epithelial cell + The morphology of a podocyte. + morphology of podocyte podocyte morphology trait - The morphology of a glomerular visceral epithelial cell. + The morphology of a podocyte. AUTO:patterns/patterns/entity_attribute - morphology of glomerular visceral epithelial cell + morphology of podocyte AUTO:patterns/patterns/entity_attribute @@ -254578,7 +261454,10 @@ The circumference of a chest. + + chest girth circumference of chest + girth of chest chest circumference @@ -258257,6 +265136,12 @@ + + + + + + @@ -269759,6 +276644,12 @@ + + + + + + @@ -286861,36 +293752,6 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -455011,6 +461872,36 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -486189,7 +493080,7 @@ - + @@ -486203,7 +493094,7 @@ - + @@ -489151,36 +496042,6 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -489991,6 +496852,36 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/oba.obo b/oba.obo index ff295f72..135c66c0 100644 --- a/oba.obo +++ b/oba.obo @@ -1,8 +1,5 @@ format-version: 1.2 -data-version: releases/2022-01-19 -date: 13:11:2015 10:21 -saved-by: cjmungall -auto-generated-by: TermGenie 1.0 +data-version: releases/2022-08-03 subsetdef: 1_STAR "" subsetdef: 2_STAR "" subsetdef: 3_STAR "" @@ -16,15 +13,18 @@ subsetdef: BDS_subset "" subsetdef: cell_quality "" subsetdef: Citrus "" subsetdef: CL "" +subsetdef: clingen "" subsetdef: cumbo "" subsetdef: defined_by_ordinal_series "" subsetdef: developmental_classification "" +subsetdef: disease_grouping "" subsetdef: disposition_slim "" subsetdef: early_development "" subsetdef: efo_slim "" subsetdef: emapa_ehdaa2 "" subsetdef: feed_aligned "" subsetdef: functional_classification "" +subsetdef: gard_rare "" subsetdef: gocheck_do_not_annotate "" subsetdef: gocheck_do_not_manually_annotate "" subsetdef: goslim_agr "" @@ -43,23 +43,58 @@ subsetdef: goslim_synapse "" subsetdef: goslim_yeast "" subsetdef: grouping_class "" subsetdef: Gymnosperms "" +subsetdef: harrisons_view "" subsetdef: homology_grouping "" subsetdef: hpo_slim "" +subsetdef: hposlim_core "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term "" subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology "" subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam "" +subsetdef: human_reference_atlas "" subsetdef: inconsistent_with_fma "" +subsetdef: location_grouping "" subsetdef: Maize "" subsetdef: major_organ "" +subsetdef: merged_class "" subsetdef: mpath_slim "" subsetdef: Musa "" +subsetdef: NCIT:C105551 "" +subsetdef: NCIT:C116977 "" +subsetdef: NCIT:C118169 "" +subsetdef: NCIT:C120531 "" +subsetdef: NCIT:C156952 "" +subsetdef: NCIT:C156953 "" +subsetdef: NCIT:C156954 "" +subsetdef: NCIT:C157529 "" +subsetdef: NCIT:C157711 "" +subsetdef: NCIT:C159106 "" +subsetdef: NCIT:C159501 "" +subsetdef: NCIT:C159503 "" +subsetdef: NCIT:C165451 "" +subsetdef: NCIT:C166371 "" +subsetdef: NCIT:C166372 "" +subsetdef: NCIT:C54447 "" +subsetdef: NCIT:C61410 "" +subsetdef: NCIT:C67497 "" +subsetdef: NCIT:C77526 "" +subsetdef: NCIT:C89506 "" +subsetdef: NCIT:C90259 "" subsetdef: non_informative "" +subsetdef: obsoletion_candidate "" +subsetdef: ordo_clinical_subtype "" +subsetdef: ordo_clinical_syndrome "" +subsetdef: ordo_disease "" +subsetdef: ordo_group_of_disorders "" +subsetdef: ordo_histopathological_subtype "" subsetdef: organ_slim "" subsetdef: pheno_slim "" subsetdef: phenotype_rcn "" subsetdef: Poaceae "" subsetdef: Potato "" +subsetdef: predisposition "" +subsetdef: prokaryote_subset "" +subsetdef: prototype_pattern "" subsetdef: Pteridophytes "" subsetdef: reference "" subsetdef: relational_slim "" @@ -76,34 +111,162 @@ subsetdef: unverified_taxonomic_grouping "" subsetdef: upper_level "" subsetdef: value_slim "" subsetdef: vertebrate_core "" +synonymtypedef: ABBREVIATION "" +synonymtypedef: abbreviation "" +synonymtypedef: AMBIGUOUS "" +synonymtypedef: blast_name "" +synonymtypedef: BRAND_NAME "" +synonymtypedef: common_name "" +synonymtypedef: COMPARATIVE_PREFERRED "" +synonymtypedef: DEPRECATED "" +synonymtypedef: DEVELOPMENTAL "" +synonymtypedef: DUBIOUS "" +synonymtypedef: equivalent_name "" +synonymtypedef: genbank_common_name "" +synonymtypedef: Gene-based "" +synonymtypedef: HOMOLOGY "" +synonymtypedef: HUMAN_PREFERRED "" +synonymtypedef: in_part "" +synonymtypedef: INCONSISTENT "" +synonymtypedef: INN "" +synonymtypedef: IUPAC_NAME "" +synonymtypedef: Japanese "" +synonymtypedef: LATIN "" +synonymtypedef: layperson "" +synonymtypedef: MISSPELLING "" +synonymtypedef: NON_AMNIOTE "" +synonymtypedef: NON_MAMMAL "" +synonymtypedef: PENDING_REVIEW "" +synonymtypedef: PLURAL "" +synonymtypedef: Plural "" +synonymtypedef: plural_form "" +synonymtypedef: PRO-short-label "" +synonymtypedef: scientific_name "" +synonymtypedef: SENSU "" +synonymtypedef: Spanish "" +synonymtypedef: syngo_official_label "" +synonymtypedef: synonym "" +synonymtypedef: SYSTEMATIC "" +synonymtypedef: systematic_synonym "" +synonymtypedef: uk_spelling "" default-namespace: oba ontology: oba property_value: http://purl.org/dc/elements/1.1/description "A collection of biological attributes (traits) covering all kingdoms of life. Interoperable with VT (vertebrate trait ontology) and TO (plant trait ontology). Extends PATO." xsd:string property_value: http://purl.org/dc/elements/1.1/title "Ontology of Biological Attributes (OBA)" xsd:string property_value: http://purl.org/dc/terms/license http://creativecommons.org/publicdomain/zero/1.0/ -property_value: owl:versionInfo "2022-01-19" xsd:string -property_value: property-value "foaf-homepage \"http://wiki.geneontology.org/index.php/Extensions/x-attribute\" xsd:anyURL" xsd:string +property_value: owl:versionInfo "2022-08-03" xsd:string + +[Term] +id: BFO:0000001 +name: entity +property_value: BFO:0000179 "entity" xsd:string +property_value: BFO:0000180 "Entity" xsd:string +property_value: editor_note "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string +property_value: editor_note "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", http://www.w3.org/2000/01/rdf-schema#seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"} +property_value: IAO:0000111 "entity" xsd:string +property_value: IAO:0000112 "Julius Caesar" xsd:string +property_value: IAO:0000112 "the Second World War" xsd:string +property_value: IAO:0000112 "Verdi’s Requiem" xsd:string +property_value: IAO:0000112 "your body mass index" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/agro.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ecocore.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ons.owl +property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000002 name: continuant def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." [] +is_a: BFO:0000001 ! entity disjoint_from: BFO:0000003 ! occurrent relationship: part_of BFO:0000002 ! continuant +property_value: BFO:0000179 "continuant" xsd:string +property_value: BFO:0000180 "Continuant" xsd:string +property_value: editor_note "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string +property_value: editor_note "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"} +property_value: IAO:0000111 "continuant" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/agro.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ons.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} +property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} +property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} +property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} +property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"} +property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"} +property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"} +property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000003 name: occurrent def: "An entity that has temporal parts and that happens, unfolds or develops through time." [] +is_a: BFO:0000001 ! entity relationship: part_of BFO:0000003 ! occurrent +property_value: BFO:0000179 "occurrent" xsd:string +property_value: BFO:0000180 "Occurrent" xsd:string +property_value: editor_note "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string +property_value: editor_note "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string +property_value: editor_note "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000006", comment="per discussion with Barry Smith"} +property_value: editor_note "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000012"} +property_value: IAO:0000412 http://purl.obolibrary.org/obo/agro.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ecocore.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +property_value: IAO:0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/077-002"} +property_value: IAO:0000601 "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} +property_value: IAO:0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} +property_value: IAO:0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"} +property_value: IAO:0000602 "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000004 name: independent continuant def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." [] +def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} +def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000020 ! specifically dependent continuant +disjoint_from: BFO:0000020 ! specifically dependent continuant +disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000004 ! independent continuant +property_value: BFO:0000179 "ic" xsd:string +property_value: BFO:0000180 "IndependentContinuant" xsd:string +property_value: IAO:0000112 "a chair" xsd:string +property_value: IAO:0000112 "a heart" xsd:string +property_value: IAO:0000112 "a leg" xsd:string +property_value: IAO:0000112 "a molecule" xsd:string +property_value: IAO:0000112 "a spatial region" xsd:string +property_value: IAO:0000112 "an atom" xsd:string +property_value: IAO:0000112 "an orchestra." xsd:string +property_value: IAO:0000112 "an organism" xsd:string +property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string +property_value: IAO:0000112 "the interior of your mouth" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/agro.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} +property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} +property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"} +property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"} +property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000006 @@ -114,13 +277,44 @@ is_a: BFO:0000141 ! immaterial entity id: BFO:0000015 name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] +def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"} +def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] is_a: BFO:0000003 ! occurrent +property_value: BFO:0000179 "process" xsd:string +property_value: BFO:0000180 "Process" xsd:string +property_value: editor_note "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string +property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string +property_value: IAO:0000112 "a process of meiosis" xsd:string +property_value: IAO:0000112 "a process of sleeping" xsd:string +property_value: IAO:0000112 "the course of a disease" xsd:string +property_value: IAO:0000112 "the flight of a bird" xsd:string +property_value: IAO:0000112 "the life of an organism" xsd:string +property_value: IAO:0000112 "your process of aging." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/agro.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ecocore.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +property_value: IAO:0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000016 name: disposition is_a: BFO:0000017 ! realizable entity disjoint_from: BFO:0000023 ! role +property_value: BFO:0000179 "disposition" xsd:string +property_value: BFO:0000180 "Disposition" xsd:string +property_value: editor_note "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type." xsd:string +property_value: IAO:0000112 "an atom of element X has the disposition to decay to an atom of element Y" xsd:string +property_value: IAO:0000112 "certain people have a predisposition to colon cancer" xsd:string +property_value: IAO:0000112 "children are innately disposed to categorize objects in certain ways." xsd:string +property_value: IAO:0000112 "the cell wall is disposed to filter chemicals in endocytosis and exocytosis" xsd:string +property_value: IAO:0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"} +property_value: IAO:0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"} +property_value: IAO:0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"} +property_value: IAO:0000602 "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000017 @@ -129,19 +323,67 @@ def: "A specifically dependent continuant that inheres in continuant entities is_a: BFO:0000020 ! specifically dependent continuant disjoint_from: BFO:0000019 ! quality relationship: part_of BFO:0000017 ! realizable entity +property_value: BFO:0000179 "realizable" xsd:string +property_value: BFO:0000180 "RealizableEntity" xsd:string +property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string +property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string +property_value: IAO:0000112 "the function of your reproductive organs" xsd:string +property_value: IAO:0000112 "the role of being a doctor" xsd:string +property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string +property_value: IAO:0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"} +property_value: IAO:0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"} +property_value: IAO:0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"} +property_value: IAO:0000602 "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000019 name: quality is_a: BFO:0000020 ! specifically dependent continuant relationship: part_of BFO:0000019 ! quality +property_value: BFO:0000179 "quality" xsd:string +property_value: BFO:0000180 "Quality" xsd:string +property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string +property_value: IAO:0000112 "the color of a tomato" xsd:string +property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string +property_value: IAO:0000112 "the mass of this piece of gold." xsd:string +property_value: IAO:0000112 "the shape of your nose" xsd:string +property_value: IAO:0000112 "the shape of your nostril" xsd:string +property_value: IAO:0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"} +property_value: IAO:0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"} +property_value: IAO:0000602 "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"} +property_value: IAO:0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000020 name: specifically dependent continuant def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." [] +def: "b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])" [] +def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} is_a: BFO:0000002 ! continuant +disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 ! specifically dependent continuant +property_value: BFO:0000179 "sdc" xsd:string +property_value: BFO:0000180 "SpecificallyDependentContinuant" xsd:string +property_value: editor_note "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000005", comment="per discussion with Barry Smith"} +property_value: IAO:0000111 "specifically dependent continuant" xsd:string +property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string +property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string +property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string +property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string +property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string +property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string +property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string +property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string +property_value: IAO:0000112 "the role of being a doctor" xsd:string +property_value: IAO:0000112 "the shape of this hole." xsd:string +property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ons.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl +property_value: IAO:0000602 "(iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004] " xsd:string +property_value: IAO:0000602 "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000023 @@ -152,9 +394,24 @@ equivalent_to: CHEBI:50906 ! role [Term] id: BFO:0000024 +name: fiat object name: fiat object part namespace: bfo is_a: BFO:0000040 ! material entity +property_value: BFO:0000179 "fiat-object-part" xsd:string +property_value: BFO:0000180 "FiatObjectPart" xsd:string +property_value: editor_note "BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions" xsd:string +property_value: IAO:0000112 "or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29" xsd:string +property_value: IAO:0000112 "the division of the brain into regions" xsd:string +property_value: IAO:0000112 "the division of the planet into hemispheres" xsd:string +property_value: IAO:0000112 "the dorsal and ventral surfaces of the body" xsd:string +property_value: IAO:0000112 "the FMA:regional parts of an intact human body." xsd:string +property_value: IAO:0000112 "the upper and lower lobes of the left lung" xsd:string +property_value: IAO:0000112 "the Western hemisphere of the Earth" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000600 "b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/027-004"} +property_value: IAO:0000602 "(forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/027-004"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000030 @@ -162,6 +419,21 @@ name: object namespace: bfo is_a: BFO:0000040 ! material entity +[Term] +id: BFO:0000031 +name: generically dependent continuant +def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." [] +def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} +is_a: BFO:0000002 ! continuant +relationship: part_of BFO:0000031 ! generically dependent continuant +property_value: BFO:0000179 "gdc" xsd:string +property_value: BFO:0000180 "GenericallyDependentContinuant" xsd:string +property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string +property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string +property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string +property_value: IAO:0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl + [Term] id: BFO:0000034 name: function @@ -174,28 +446,314 @@ namespace: bfo def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." [] is_a: BFO:0000004 ! independent continuant disjoint_from: BFO:0000141 ! immaterial entity +property_value: BFO:0000179 "material" xsd:string +property_value: BFO:0000180 "MaterialEntity" xsd:string +property_value: editor_note "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string +property_value: editor_note "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string +property_value: editor_note "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string +property_value: IAO:0000112 "a flame" xsd:string +property_value: IAO:0000112 "a forest fire" xsd:string +property_value: IAO:0000112 "a human being" xsd:string +property_value: IAO:0000112 "a hurricane" xsd:string +property_value: IAO:0000112 "a photon" xsd:string +property_value: IAO:0000112 "a puff of smoke" xsd:string +property_value: IAO:0000112 "a sea wave" xsd:string +property_value: IAO:0000112 "a tornado" xsd:string +property_value: IAO:0000112 "an aggregate of human beings." xsd:string +property_value: IAO:0000112 "an energy wave" xsd:string +property_value: IAO:0000112 "an epidemic" xsd:string +property_value: IAO:0000112 "the undetached arm of a human being" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/dron.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} +property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} +property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} +property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"} +property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"} +property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Term] id: BFO:0000141 name: immaterial entity is_a: BFO:0000004 ! independent continuant +[Term] +id: BFO:0000144 +name: process profile +def: "b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])" [] {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/093-002"} +is_a: BFO:0000015 ! process +property_value: BFO:0000179 "process-profile" xsd:string +property_value: BFO:0000180 "ProcessProfile" xsd:string +property_value: IAO:0000112 "On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels" xsd:string +property_value: IAO:0000112 "One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance." xsd:string +property_value: IAO:0000112 "The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on." xsd:string +property_value: IAO:0000600 "b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])" xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/094-005"} +property_value: IAO:0000602 "(forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/094-005"} +property_value: IAO:0000602 "(iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] " xsd:string {http://purl.obolibrary.org/obo/IAO_0010000="http://purl.obolibrary.org/obo/bfo/axiom/093-002"} +property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl + [Term] id: CARO:0000000 name: anatomical entity is_a: CARO:0030000 ! biological entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl +[Term] +id: CARO:0000003 +name: connected anatomical structure +is_a: CARO:0000006 ! material anatomical entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl + +[Term] +id: CARO:0000006 +name: material anatomical entity +is_a: BFO:0000040 ! material entity +is_a: CARO:0000000 ! anatomical entity +relationship: drains CARO:0000003 ! connected anatomical structure +property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl + +[Term] +id: CARO:0000007 +name: immaterial anatomical entity +is_a: BFO:0000141 ! immaterial entity + +[Term] +id: CARO:0001000 +name: multi-cell-part structure +is_a: CARO:0000003 ! connected anatomical structure +property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl + +[Term] +id: CARO:0001001 +name: neuron projection bundle +is_a: CARO:0001000 ! multi-cell-part structure +property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl + [Term] id: CARO:0001010 name: organism or virus or viroid is_a: BFO:0000040 ! material entity +[Term] +id: CARO:0010000 +name: multicellular anatomical structure +is_a: CARO:0000003 ! connected anatomical structure +relationship: directly_develops_from CARO:0010000 ! multicellular anatomical structure +property_value: IAO:0000412 http://purl.obolibrary.org/obo/caro.owl + [Term] id: CARO:0030000 name: biological entity is_a: BFO:0000004 ! independent continuant +[Term] +id: CHEBI:10033 +name: warfarin +namespace: chebi_ontology +def: "A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice." [] +subset: 3_STAR +synonym: "(+/-)-Warfarin" RELATED [NIST_Chemistry_WebBook] +synonym: "(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine" RELATED [ChemIDplus] +synonym: "(RS)-Warfarin" RELATED [NIST_Chemistry_WebBook] +synonym: "1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone" RELATED [ChemIDplus] +synonym: "2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-" RELATED [ChemIDplus] +synonym: "3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin" RELATED [ChemIDplus] +synonym: "3-(Acetonylbenzyl)-4-hydroxycoumarin" RELATED [NIST_Chemistry_WebBook] +synonym: "3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin" RELATED [NIST_Chemistry_WebBook] +synonym: "3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin" RELATED [ChemIDplus] +synonym: "3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin" RELATED [ChemIDplus] +synonym: "4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin" RELATED [ChemIDplus] +synonym: "4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin" RELATED [ChEBI] +synonym: "Coumafene" RELATED [ChemIDplus] +synonym: "DL-3-(alpha-acetonylbenzyl)-4-hydroxycoumarin" RELATED [NIST_Chemistry_WebBook] +synonym: "DL-warfarin" RELATED [ChEBI] +synonym: "rac-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "rac-warfarin" RELATED [ChEBI] +synonym: "racemic warfarin" RELATED [ChEBI] +synonym: "Warf 10" RELATED BRAND_NAME [DrugBank] +synonym: "warfarin" RELATED INN [ChemIDplus] +synonym: "warfarina" RELATED INN [ChemIDplus] +synonym: "warfarine" RELATED INN [ChemIDplus] +synonym: "warfarinum" RELATED INN [ChemIDplus] +synonym: "Zoocoumarin" RELATED [ChemIDplus] +xref: Beilstein:1293536 {source="Beilstein"} +xref: CAS:81-81-2 {source="KEGG COMPOUND"} +xref: CAS:81-81-2 {source="ChemIDplus"} +xref: CAS:81-81-2 {source="NIST Chemistry WebBook"} +xref: DrugBank:DB00682 +xref: HMDB:HMDB0001935 +xref: KEGG:C01541 +xref: KEGG:D08682 +xref: Patent:US2427578 +xref: Patent:US2765321 +xref: Patent:US2777859 +xref: Patent:US3239529 +xref: PMID:13358873 {source="Europe PMC"} +xref: PMID:15578879 {source="Europe PMC"} +xref: PMID:18294321 {source="Europe PMC"} +xref: PMID:19294412 {source="Europe PMC"} +xref: PMID:24478171 {source="Europe PMC"} +xref: PMID:24973057 {source="Europe PMC"} +xref: PMID:25022924 {source="Europe PMC"} +xref: PMID:25023204 {source="Europe PMC"} +xref: PMID:25393417 {source="Europe PMC"} +xref: PMID:25466603 {source="Europe PMC"} +xref: PMID:25534862 {source="Europe PMC"} +xref: PMID:25537751 {source="Europe PMC"} +xref: PMID:25555316 {source="Europe PMC"} +xref: PMID:25683623 {source="Europe PMC"} +xref: PMID:25757926 {source="Europe PMC"} +xref: PMID:25823787 {source="Europe PMC"} +xref: PMID:25828628 {source="Europe PMC"} +xref: PMID:25830869 {source="Europe PMC"} +xref: PMID:25842804 {source="Europe PMC"} +xref: PMID:25845131 {source="Europe PMC"} +xref: PMID:25986145 {source="Europe PMC"} +xref: PMID:26114209 {source="Europe PMC"} +xref: PMID:26142522 {source="Europe PMC"} +xref: PMID:26142525 {source="Europe PMC"} +xref: PMID:26203765 {source="Europe PMC"} +xref: PMID:26238769 {source="Europe PMC"} +xref: Reaxys:1293536 {source="Reaxys"} +xref: Wikipedia:Warfarin +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:87737 ! (R)-warfarin +relationship: has_part CHEBI:87738 ! (S)-warfarin +relationship: has_role CHEBI:33288 ! rodenticide +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50390 ! EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor +relationship: has_role CHEBI:55347 ! vitamin K antagonist +relationship: is_conjugate_acid_of CHEBI:50393 ! warfarin(1-) + +[Term] +id: CHEBI:10112 +name: zileuton +namespace: chebi_ontology +def: "A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma." [] +subset: 3_STAR +synonym: "(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea" RELATED [ChEBI] +synonym: "1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea" EXACT IUPAC_NAME [IUPAC] +synonym: "Leutrol" RELATED [ChemIDplus] +synonym: "N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea" RELATED [ChemIDplus] +synonym: "N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea" RELATED [ChEBI] +synonym: "Zileuton" EXACT [KEGG_DRUG] +synonym: "zileuton" RELATED INN [WHO_MedNet] +synonym: "zileuton" RELATED INN [ChemIDplus] +synonym: "zileutonum" RELATED INN [ChemIDplus] +synonym: "Zyflo" RELATED BRAND_NAME [KEGG_DRUG] +xref: CAS:111406-87-2 {source="ChemIDplus"} +xref: CAS:111406-87-2 {source="KEGG DRUG"} +xref: Drug_Central:2862 {source="DrugCentral"} +xref: DrugBank:DB00744 +xref: KEGG:D00414 +xref: LINCS:LSM-5084 +xref: PMID:19309543 {source="Europe PMC"} +xref: PMID:19645854 {source="Europe PMC"} +xref: PMID:20204486 {source="Europe PMC"} +xref: PMID:20436887 {source="Europe PMC"} +xref: Reaxys:4869674 {source="Reaxys"} +xref: Wikipedia:Zileuton +is_a: CHEBI:38836 ! 1-benzothiophenes +is_a: CHEBI:47857 ! ureas +relationship: has_parent_hydride CHEBI:35858 ! 1-benzothiophene +relationship: has_role CHEBI:173084 ! ferroptosis inhibitor +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:49159 ! leukotriene antagonist +relationship: has_role CHEBI:49167 ! anti-asthmatic drug +relationship: has_role CHEBI:64964 ! EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H12N2O2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MWLSOWXNZPKENC-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "236.29126" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "236.06195" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(N(O)C(N)=O)c1cc2ccccc2s1" xsd:string + +[Term] +id: CHEBI:10119 +name: ziprasidone +namespace: chebi_ontology +def: "A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [] +subset: 3_STAR +synonym: "5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "ziprasidona" RELATED INN [ChEBI] +synonym: "Ziprasidone" EXACT [KEGG_COMPOUND] +synonym: "ziprasidone" RELATED INN [ChEBI] +synonym: "ziprasidone" RELATED INN [KEGG_DRUG] +synonym: "ziprasidonum" RELATED INN [ChEBI] +xref: Beilstein:6669199 {source="Beilstein"} +xref: CAS:146939-27-7 {source="ChemIDplus"} +xref: CAS:146939-27-7 {source="DrugBank"} +xref: CAS:146939-27-7 {source="KEGG DRUG"} +xref: Drug_Central:2865 {source="DrugCentral"} +xref: DrugBank:DB00246 +xref: KEGG:C07568 +xref: KEGG:D08687 +xref: LINCS:LSM-5433 +xref: Patent:EP281309 +xref: Patent:US4831031 +xref: Wikipedia:Ziprasidone +is_a: CHEBI:24829 ! indolones +is_a: CHEBI:26144 ! piperazines +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:55505 ! 1,2-benzisothiazole +relationship: has_role CHEBI:35476 ! antipsychotic agent +relationship: has_role CHEBI:37956 ! histamine antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:48876 ! muscarinic antagonist +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H21ClN4OS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MVWVFYHBGMAFLY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "412.93600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "412.11246" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12" xsd:string + +[Term] +id: CHEBI:10127 +name: zonisamide +namespace: chebi_ontology +alt_id: CHEBI:139857 +def: "A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position." [] +subset: 3_STAR +synonym: "1,2-Benzisoxazole-3-methanesulfonamide" RELATED [ChemIDplus] +synonym: "1-(1,2-benzisoxazol-3-yl)methanesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "3-(Sulfamoylmethyl)-1,2-benzisoxazole" RELATED [ChemIDplus] +synonym: "Benzo[d]isoxazol-3-yl-methanesulfonamide" RELATED [ChEMBL] +synonym: "zonisamida" RELATED INN [DrugBank] +synonym: "zonisamide" RELATED INN [KEGG_DRUG] +synonym: "zonisamidum" RELATED INN [DrugBank] +xref: Beilstein:1077076 {source="Beilstein"} +xref: CAS:68291-97-4 {source="DrugBank"} +xref: CAS:68291-97-4 {source="ChemIDplus"} +xref: CAS:68291-97-4 {source="KEGG DRUG"} +xref: CAS:68291-97-4 {source="KEGG COMPOUND"} +xref: Drug_Central:2872 {source="DrugCentral"} +xref: DrugBank:DB00909 +xref: KEGG:C07504 +xref: KEGG:D00538 +xref: LINCS:LSM-3062 +xref: Patent:JP7877057 +xref: Patent:US4172896 +xref: Wikipedia:Zonisamide +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:51545 ! 1,2-benzoxazoles +relationship: has_role CHEBI:22586 ! antioxidant +relationship: has_role CHEBI:35623 ! anticonvulsant +relationship: has_role CHEBI:50267 ! protective agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H8N2O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UBQNRHZMVUUOMG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "212.22600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "212.02556" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NS(=O)(=O)Cc1noc2ccccc12" xsd:string + [Term] id: CHEBI:10545 name: electron @@ -222,6 +780,106 @@ property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.000548579903" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string +[Term] +id: CHEBI:114785 +name: erlotinib +namespace: chebi_ontology +alt_id: CHEBI:40877 +def: "A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions." [] +subset: 3_STAR +synonym: "[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine" RELATED [PDBeChem] +synonym: "[6,7-bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine" RELATED [DrugBank] +synonym: "erlotinib" RELATED INN [WHO_MedNet] +synonym: "erlotinibum" RELATED INN [WHO_MedNet] +synonym: "N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine" EXACT IUPAC_NAME [IUPAC] +xref: CAS:183321-74-6 {source="KEGG DRUG"} +xref: CAS:183321-74-6 {source="ChemIDplus"} +xref: CAS:183321-74-6 {source="DrugBank"} +xref: Drug_Central:1045 {source="DrugCentral"} +xref: DrugBank:DB00530 +xref: HMDB:HMDB0014671 +xref: KEGG:D07907 +xref: LINCS:LSM-1097 +xref: Patent:US2010094004 +xref: PDBeChem:AQ4 +xref: PMID:12270171 {source="ChEMBL"} +xref: PMID:14684309 {source="ChEMBL"} +xref: PMID:15711537 {source="ChEMBL"} +xref: PMID:16014882 {source="Europe PMC"} +xref: PMID:16014883 {source="Europe PMC"} +xref: PMID:16480284 {source="ChEMBL"} +xref: PMID:17889528 {source="ChEMBL"} +xref: PMID:17983745 {source="ChEMBL"} +xref: PMID:29448920 {source="Europe PMC"} +xref: PMID:29579331 {source="Europe PMC"} +xref: PMID:29687154 {source="Europe PMC"} +xref: PMID:30039303 {source="Europe PMC"} +xref: PMID:30071517 {source="Europe PMC"} +xref: PMID:30150014 {source="Europe PMC"} +xref: PMID:30158288 {source="Europe PMC"} +xref: Reaxys:8798958 {source="Reaxys"} +xref: Wikipedia:Erlotinib +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:38530 ! quinazolines +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:73477 ! terminal acetylenic compound +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:74440 ! epidermal growth factor receptor antagonist +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H23N3O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AAKJLRGGTJKAMG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "393.43570" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "393.16886" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC" xsd:string + +[Term] +id: CHEBI:119486 +name: efavirenz +namespace: chebi_ontology +alt_id: CHEBI:190461 +alt_id: CHEBI:47396 +alt_id: CHEBI:4760 +def: "1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection." [] +subset: 3_STAR +synonym: "(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE" RELATED [PDBeChem] +synonym: "(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one" RELATED [ChemIDplus] +synonym: "(S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one" RELATED [ChEMBL] +synonym: "6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one" RELATED [ChEMBL] +synonym: "Efavirenz" EXACT [KEGG_COMPOUND] +xref: Beilstein:7387333 {source="Beilstein"} +xref: CAS:154598-52-4 {source="KEGG COMPOUND"} +xref: CAS:154598-52-4 {source="ChemIDplus"} +xref: Drug_Central:989 {source="DrugCentral"} +xref: DrugBank:DB00625 +xref: HMDB:HMDB0014763 +xref: KEGG:C08088 +xref: KEGG:D00896 +xref: LINCS:LSM-5526 +xref: Patent:EP582455 +xref: Patent:US5519021 +xref: PDBeChem:EFZ +xref: PMID:10576692 {source="ChEMBL"} +xref: PMID:10673109 {source="ChEMBL"} +xref: PMID:25017682 {source="Europe PMC"} +xref: Reaxys:7387333 {source="Reaxys"} +xref: Wikipedia:Efavirenz +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:46969 ! benzoxazine +is_a: CHEBI:51454 ! cyclopropanes +is_a: CHEBI:73474 ! acetylenic compound +relationship: has_role CHEBI:36044 ! antiviral drug +relationship: has_role CHEBI:53756 ! HIV-1 reverse transcriptase inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H9ClF3NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XPOQHMRABVBWPR-ZDUSSCGKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "315.67500" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "315.02739" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1" xsd:string + [Term] id: CHEBI:11955 name: 4-amino-3-hydroxybutanoate @@ -299,6 +957,19 @@ synonym: "C19-steroids" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid relationship: has_parent_hydride CHEBI:35509 ! androstane +[Term] +id: CHEBI:131860 +name: octadecanoid anion +namespace: chebi_ontology +def: "An unsaturated fatty acid anion obtained by the deprotonation of the carboxy group of any octadecanoid." [] +subset: 3_STAR +synonym: "anionic octadecanoid" RELATED [ChEBI] +synonym: "anionic octadecanoids" RELATED [ChEBI] +synonym: "octadecanoid anions" RELATED [ChEBI] +is_a: CHEBI:2580 ! unsaturated fatty acid anion +is_a: CHEBI:57560 ! long-chain fatty acid anion +relationship: is_conjugate_base_of CHEBI:36326 ! octadecanoid + [Term] id: CHEBI:131927 name: dicarboxylic acids and O-substituted derivatives @@ -308,6 +979,23 @@ subset: 3_STAR synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI] is_a: CHEBI:36586 ! carbonyl compound +[Term] +id: CHEBI:132102 +name: buspirone(1+) +namespace: chebi_ontology +def: "An ammonium ion resulting from the addition of a proton to the piperazine nitrogen that is not attached to the pyrimidinyl group. The major species at pH 7.3." [] +subset: 3_STAR +synonym: "1-[4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-4-(pyrimidin-2-yl)piperazin-1-ium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:3223 ! buspirone +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H32N5O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QWCRAEMEVRGPNT-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "386.512" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "386.25505" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1N=C(N=CC1)N2CC[NH+](CC2)CCCCN3C(CC4(CC3=O)CCCC4)=O" xsd:string + [Term] id: CHEBI:132153 name: hyaluronate @@ -322,6 +1010,59 @@ relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "(C14H20NO11)n.H2O" xsd:string +[Term] +id: CHEBI:132233 +name: 1-phenylpropan-2-amine +namespace: chebi_ontology +def: "A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group." [] +subset: 3_STAR +synonym: "1-phenylpropan-2-amine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:32877 ! primary amine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KWTSXDURSIMDCE-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "135.207" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.10480" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1(C=CC=CC1)CC(C)N" xsd:string + +[Term] +id: CHEBI:132294 +name: phenylephrine(1+) +namespace: chebi_ontology +def: "An organic cation obtained by protonation of the secondary amino function of phenylephrine." [] +subset: 3_STAR +synonym: "(2R)-2-hydroxy-2-(3-hydroxyphenyl)-N-methylethan-1-aminium" EXACT IUPAC_NAME [IUPAC] +synonym: "phenylephrine cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:8093 ! phenylephrine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H14NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/p+1/t9-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SONNWYBIRXJNDC-VIFPVBQESA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "168.213" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "168.10191" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C(=CC=CC1[C@H](C[NH2+]C)O)O" xsd:string + +[Term] +id: CHEBI:132297 +name: methamphetamine(1+) +namespace: chebi_ontology +def: "An organic cation obtained by protonation of the secondary amino function of methamphetamine." [] +subset: 3_STAR +synonym: "(2S)-N-methyl-1-phenylpropan-2-aminium" EXACT IUPAC_NAME [IUPAC] +synonym: "methamphetamine cation" RELATED [ChEBI] +is_a: CHEBI:137419 ! secondary ammonium ion +relationship: is_conjugate_acid_of CHEBI:6809 ! methamphetamine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H16N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/p+1/t9-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYWUZJCMWCOHBA-VIFPVBQESA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "150.241" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "150.12773" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1(C[C@@H]([NH2+]C)C)C=CC=CC1" xsd:string + [Term] id: CHEBI:132951 name: maleate @@ -344,6 +1085,7 @@ def: "A peptide cation obtained by deprotonation of the carboxy group and proton subset: 3_STAR synonym: "1-[(2S)-2-azaniumyl-5-carbamimidamidopentanoyl]-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-N-[(1S)-4-carbamimidamido-1-carboxylatobutyl]-L-phenylalaninamide" EXACT IUPAC_NAME [IUPAC] synonym: "1-[(2S)-2-azaniumyl-5-{[azaniumyl(imino)methyl]amino}pentanoyl]-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-N-[(1S)-4-{[azaniumyl(imino)methyl]amino}-1-carboxylatobutyl]-L-phenylalaninamide" EXACT IUPAC_NAME [IUPAC] +synonym: "bradykinin" RELATED [UniProt] is_a: CHEBI:60466 ! peptide zwitterion relationship: is_tautomer_of CHEBI:3165 ! bradykinin property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string @@ -354,6 +1096,23 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "1062.226" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1061.57595" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=[NH2+])(NCCC[C@@H](C(=O)N1[C@H](C(N2[C@H](C(=O)NCC(N[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(N[C@H](C([O-])=O)CCCNC(=[NH2+])N)=O)CC=4C=CC=CC4)CCC3)CO)=O)CC=5C=CC=CC5)=O)CCC2)=O)CCC1)[NH3+])N" xsd:string +[Term] +id: CHEBI:132992 +name: radiosensitizing agent +namespace: chebi_ontology +def: "A drug that makes increases the sensitivity of tumour cells to radiation therapy." [] +subset: 3_STAR +synonym: "radiosensitiser" RELATED [ChEBI] +synonym: "radiosensitisers" RELATED [ChEBI] +synonym: "radiosensitising agent" RELATED [ChEBI] +synonym: "radiosensitising agents" RELATED [ChEBI] +synonym: "radiosensitizer" RELATED [ChEBI] +synonym: "radiosensitizers" RELATED [ChEBI] +synonym: "radiosensitizing agents" RELATED [ChEBI] +xref: PMID:12520460 {source="Europe PMC"} +xref: Wikipedia:Radiosensitizer +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:134179 name: volatile organic compound @@ -396,6 +1155,109 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "55.055" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "55.01839" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C(=C(*)*)*)(O)([H])[H]" xsd:string +[Term] +id: CHEBI:134504 +name: tenofovir(1-) +namespace: chebi_ontology +def: "A phosphorus oxoanion resulting from the removal of one proton from the phosphonic acid group of tenofovir. The major microspecies at pH 7.3." [] +subset: 3_STAR +synonym: "hydrogen ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate" EXACT IUPAC_NAME [IUPAC] +synonym: "tenofovir" RELATED [UniProt] +synonym: "tenofovir (1-)" RELATED [ChEBI] +xref: PMID:15914676 {source="SUBMITTER"} +is_a: CHEBI:33461 ! phosphorus oxoanion +relationship: has_role CHEBI:36044 ! antiviral drug +relationship: has_role CHEBI:53756 ! HIV-1 reverse transcriptase inhibitor +relationship: is_conjugate_base_of CHEBI:63625 ! tenofovir (anhydrous) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13N5O4P" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/p-1/t6-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGOIRFVFHAKUTI-ZCFIWIBFSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "286.205" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "286.07106" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1(C=2C(=C(N)N=CN2)N=C1)C[C@H](OCP(O)(=O)[O-])C" xsd:string + +[Term] +id: CHEBI:135752 +name: tafenoquine +namespace: chebi_ontology +def: "A racemate comprising equimolar amounts of (R)- and (S)-tafenoquine." [] +subset: 3_STAR +synonym: "Arakoda" RELATED BRAND_NAME [ChEBI] +synonym: "etaquine" RELATED [ChEBI] +synonym: "Krintafel" RELATED BRAND_NAME [ChEBI] +synonym: "rac-N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine" EXACT IUPAC_NAME [IUPAC] +synonym: "tafenoquina" RELATED INN [WHO_MedNet] +synonym: "tafenoquine" RELATED INN [ChemIDplus] +synonym: "tafenoquine" RELATED INN [WHO_MedNet] +synonym: "tafenoquinum" RELATED INN [ChEBI] +synonym: "WR 238,605" RELATED [ChEBI] +synonym: "WR238605" RELATED [ChEBI] +xref: CAS:106635-80-7 {source="DrugCentral"} +xref: CAS:106635-80-7 {source="ChemIDplus"} +xref: Drug_Central:3578 {source="DrugCentral"} +xref: DrugBank:DB06608 +xref: KEGG:D10490 +xref: PMID:23701202 {source="Europe PMC"} +xref: PMID:25663384 {source="Europe PMC"} +xref: PMID:25870069 {source="Europe PMC"} +xref: PMID:25891812 {source="Europe PMC"} +xref: PMID:25921416 {source="Europe PMC"} +xref: PMID:26187807 {source="Europe PMC"} +xref: PMID:26195527 {source="Europe PMC"} +xref: PMID:26500351 {source="Europe PMC"} +xref: PMID:26610844 {source="Europe PMC"} +xref: PMID:26888075 {source="Europe PMC"} +xref: PMID:27405118 {source="Europe PMC"} +xref: PMID:27528800 {source="Europe PMC"} +xref: PMID:27697758 {source="Europe PMC"} +xref: PMID:27855400 {source="Europe PMC"} +xref: PMID:28043395 {source="Europe PMC"} +xref: PMID:28214869 {source="Europe PMC"} +xref: PMID:28319724 {source="Europe PMC"} +xref: PMID:28495354 {source="Europe PMC"} +xref: PMID:28495355 {source="Europe PMC"} +xref: PMID:28526056 {source="Europe PMC"} +xref: PMID:28749773 {source="Europe PMC"} +xref: PMID:29121061 {source="Europe PMC"} +xref: PMID:29677199 {source="Europe PMC"} +xref: PMID:29869298 {source="Europe PMC"} +xref: Reaxys:6493037 {source="Reaxys"} +xref: Wikipedia:Tafenoquine +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:141488 ! (R)-tafenoquine +relationship: has_part CHEBI:141489 ! (S)-tafenoquine +relationship: has_role CHEBI:36335 ! trypanocidal drug +relationship: has_role CHEBI:38068 ! antimalarial +relationship: has_role CHEBI:68495 ! apoptosis inducer +relationship: has_role CHEBI:70868 ! antileishmanial agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H28F3N3O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "463.494" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "463.20828" xsd:string + +[Term] +id: CHEBI:135923 +name: migalastat +namespace: chebi_ontology +subset: 2_STAR +synonym: "1-Deoxygalactonojirimycin" RELATED [DrugCentral] +synonym: "1-Deoxygalactonojirimycin hydrochloride" RELATED [DrugCentral] +synonym: "galafold" RELATED [DrugCentral] +synonym: "GR181413A" RELATED [DrugCentral] +synonym: "migalastat HCl" RELATED [DrugCentral] +synonym: "migalastat hydrochloride" RELATED [DrugCentral] +xref: CAS:108147-54-2 {source="DrugCentral"} +xref: Drug_Central:5110 {source="DrugCentral"} +is_a: CHEBI:26151 ! piperidines +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H13NO4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5+,6-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LXBIFEVIBLOUGU-DPYQTVNSSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "163.172" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "163.08446" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@H]([C@H]([C@H](NC1)CO)O)O)O" xsd:string + [Term] id: CHEBI:13601 name: 3-oxo-5alpha-steroid @@ -417,6 +1279,47 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "273.434" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.22184" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CC[C@@]4(C2(CCC(C4)=O)C)[H]" xsd:string +[Term] +id: CHEBI:136622 +name: aci-nitro compound +namespace: chebi_ontology +def: "Organonitrogen compounds that have the general structure R(1)(R(2))C=N(O)OH (R(1),R(2) = H, organyl). They are tautomers of C-nitro compounds." [] +subset: 3_STAR +synonym: "aci-nitro compounds" RELATED [ChEBI] +synonym: "oxime N-oxide" RELATED [ChEBI] +synonym: "oxime N-oxides" RELATED [ChEBI] +is_a: CHEBI:35352 ! organonitrogen compound +relationship: has_functional_parent CHEBI:25750 ! oxime +relationship: is_tautomer_of CHEBI:35716 ! C-nitro compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNO2R2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "59.024" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.00073" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)(=[N+](O)[O-])*" xsd:string + +[Term] +id: CHEBI:136702 +name: ximelagatran (hydroxylamine form) +namespace: chebi_ontology +def: "A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted into the corresponding ethyl ester and in which the amidine group has been converted to the corresponding hydroxylamine. Tautomeric with the oxime form of ximelagatran." [] +subset: 3_STAR +synonym: "ethyl ({(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl}amino)acetate" EXACT IUPAC_NAME [IUPAC] +xref: PMID:28338626 {source="Europe PMC"} +xref: Reaxys:9741940 {source="Reaxys"} +is_a: CHEBI:140325 ! secondary carboxamide +is_a: CHEBI:140326 ! tertiary carboxamide +is_a: CHEBI:23990 ! ethyl ester +is_a: CHEBI:24709 ! hydroxylamines +is_a: CHEBI:38777 ! azetidines +relationship: is_tautomer_of CHEBI:65172 ! ximelagatran +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H35N5O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZXIBCJHYVWYIKI-PZJWPPBQSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "473.566" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "473.26382" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1N([C@@](C1)(C(=O)NCC=2C=CC(C(NO)=N)=CC2)[H])C([C@H](NCC(=O)OCC)C3CCCCC3)=O" xsd:string + [Term] id: CHEBI:136849 name: 3-oxo-Delta(4)-steroid group @@ -431,6 +1334,137 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "94.111" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.04186" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C*)*C(CC1=O)*" xsd:string +[Term] +id: CHEBI:136859 +name: pro-agent +namespace: chebi_ontology +def: "A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent." [] +subset: 3_STAR +synonym: "pro-agents" RELATED [ChEBI] +synonym: "proagent" RELATED [ChEBI] +synonym: "proagents" RELATED [ChEBI] +xref: PMID:26449612 {source="Europe PMC"} +is_a: CHEBI:33232 ! application + +[Term] +id: CHEBI:136889 +name: 5beta steroid +namespace: chebi_ontology +def: "Any steroid that has beta-configuration at position 5." [] +subset: 3_STAR +synonym: "5beta steroids" RELATED [ChEBI] +synonym: "5beta-steroid" RELATED [ChEBI] +synonym: "5beta-steroids" RELATED [ChEBI] +is_a: CHEBI:35341 ! steroid + +[Term] +id: CHEBI:13719 +name: acetylsalicylate +namespace: chebi_ontology +def: "A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group." [] +subset: 3_STAR +synonym: "2-(acetyloxy)benzoate" EXACT IUPAC_NAME [IUPAC] +synonym: "acetylsalicylate" EXACT [UniProt] +xref: Beilstein:3906821 {source="Beilstein"} +xref: HMDB:HMDB0001879 +xref: MetaCyc:CPD-524 +xref: Reaxys:3906821 {source="Reaxys"} +is_a: CHEBI:22718 ! benzoates +relationship: has_functional_parent CHEBI:30762 ! salicylate +relationship: is_conjugate_base_of CHEBI:15365 ! acetylsalicylic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H7O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BSYNRYMUTXBXSQ-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "179.14948" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.03498" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)Oc1ccccc1C([O-])=O" xsd:string + +[Term] +id: CHEBI:137419 +name: secondary ammonium ion +namespace: chebi_ontology +def: "An organic cation obtained by protonation of any secondary amino compound; major species at pH 7.3." [] +subset: 3_STAR +synonym: "a secondary amine" RELATED [UniProt] +synonym: "secondary amine(1+)" RELATED [ChEBI] +xref: MetaCyc:Secondary-Amines +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:32863 ! secondary amine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "16.023" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[NH+](*)[H]" xsd:string + +[Term] +id: CHEBI:137980 +name: metalloid atom +namespace: chebi_ontology +def: "An atom of an element that exhibits properties that are between those of metals and nonmetals, or that has a mixture of them. The term generally includes boron, silicon, germanium, arsenic, antimony, and tellurium, while carbon, aluminium, selenium, polonium, and astatine are less commonly included." [] +subset: 3_STAR +synonym: "metalloid" RELATED [ChEBI] +synonym: "metalloids" RELATED [ChEBI] +xref: Wikipedia:Metalloid +is_a: CHEBI:33250 ! atom + +[Term] +id: CHEBI:137982 +name: tertiary ammonium ion +namespace: chebi_ontology +def: "An organic cation obtained by protonation of the amino group of any tertiary amino compound." [] +subset: 3_STAR +synonym: "a tertiary amine" RELATED [UniProt] +synonym: "tertiary amine(1+)" RELATED [ChEBI] +synonym: "tertiary ammonium ions" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +relationship: is_conjugate_acid_of CHEBI:50996 ! tertiary amino compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HNR3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "15.015" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01090" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH+](*)(*)*" xsd:string + +[Term] +id: CHEBI:138000 +name: 3-(1-methylpyrrolidin-2-yl)pyridine +namespace: chebi_ontology +def: "An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2." [] +subset: 3_STAR +synonym: "3-(1-methylpyrrolidin-2-yl)pyridine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:26416 ! pyridine alkaloid +is_a: CHEBI:26456 ! pyrrolidine alkaloid +is_a: CHEBI:46775 ! N-alkylpyrrolidine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNICXCGAKADSCV-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "162.232" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "162.11570" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(C2N(CCC2)C)C=NC1" xsd:string + +[Term] +id: CHEBI:138015 +name: endocrine disruptor +namespace: chebi_ontology +def: "Any compound that can disrupt the functions of the endocrine (hormone) system" [] +subset: 3_STAR +synonym: "endocrine disrupting chemical" RELATED [ChEBI] +synonym: "endocrine disrupting chemicals" RELATED [ChEBI] +synonym: "endocrine disrupting compound" RELATED [ChEBI] +synonym: "endocrine disrupting compounds" RELATED [ChEBI] +synonym: "endocrine disruptors" RELATED [ChEBI] +synonym: "endocrine-disrupting chemical" RELATED [ChEBI] +synonym: "endocrine-disrupting chemicals" RELATED [ChEBI] +synonym: "hormonally active agent" RELATED [ChEBI] +synonym: "hormonally active agents" RELATED [ChEBI] +xref: PMID:27929035 {source="Europe PMC"} +xref: PMID:28356401 {source="Europe PMC"} +xref: PMID:28526231 {source="Europe PMC"} +xref: Wikipedia:Endocrine_disruptor +is_a: CHEBI:51061 ! hormone receptor modulator + [Term] id: CHEBI:138103 name: inorganic acid @@ -461,6 +1495,16 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "304.511" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "304.27662" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CCCC2C1(C3C(CC2)C4C(CC3)([C@](CC4)(CC)O)C)C" xsd:string +[Term] +id: CHEBI:138366 +name: bile acids +namespace: chebi_ontology +def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." [] +subset: 3_STAR +is_a: CHEBI:25384 ! monocarboxylic acid +is_a: CHEBI:35350 ! hydroxy steroid +is_a: CHEBI:36078 ! cholanoid + [Term] id: CHEBI:13850 name: apoprotein @@ -580,6 +1624,38 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "57.028" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "56.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C(=O)*)(O)(*)*" xsd:string +[Term] +id: CHEBI:140310 +name: phenyl acetates +namespace: chebi_ontology +def: "An acetate ester obtained by formal condensation of the carboxy group of acetic acid with the hydroxy group of any phenol." [] +subset: 3_STAR +synonym: "a phenyl acetate" RELATED [UniProt] +synonym: "phenyl acetate derivative" RELATED [ChEBI] +synonym: "phenyl acetate derivatives" RELATED [ChEBI] +xref: MetaCyc:Phenyl-Acetates +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:47622 ! acetate ester +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H3O2R5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "131.109" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.01330" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C(C(=C1*)*)*)*)*)OC(=O)C" xsd:string + +[Term] +id: CHEBI:140324 +name: primary carboxamide +namespace: chebi_ontology +def: "A carboxamide resulting from the formal condensation of a carboxylic acid with ammonia; formula RC(=O)NH2." [] +subset: 3_STAR +synonym: "primary carboxamides" RELATED [ChEBI] +is_a: CHEBI:37622 ! carboxamide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NOR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "44.033" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.01364" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)([H])[H]" xsd:string + [Term] id: CHEBI:140325 name: secondary carboxamide @@ -594,6 +1670,20 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "43.025" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.00581" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(*)[H]" xsd:string +[Term] +id: CHEBI:140326 +name: tertiary carboxamide +namespace: chebi_ontology +def: "A carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2)." [] +subset: 3_STAR +synonym: "tertiary carboxamides" RELATED [ChEBI] +is_a: CHEBI:37622 ! carboxamide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(*)*" xsd:string + [Term] id: CHEBI:140601 name: fatty acid 4:0 @@ -608,6 +1698,72 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(O)=O" xsd:string +[Term] +id: CHEBI:140949 +name: fatty acid 18:2 +namespace: chebi_ontology +subset: 2_STAR +synonym: "FA 18:2" RELATED [ChEBI] +synonym: "FA(18:2)" RELATED [ChEBI] +is_a: CHEBI:35366 ! fatty acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H32O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "280.452" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "280.24023" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)(O)*" xsd:string + +[Term] +id: CHEBI:141487 +name: N(4)-\{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine +namespace: chebi_ontology +def: "An aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group." [] +subset: 3_STAR +synonym: "N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:36709 ! aminoquinoline +is_a: CHEBI:50994 ! primary amino compound +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:83565 ! (trifluoromethyl)benzenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H28F3N3O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LBHLFPGPEGDCJG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "463.494" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "463.20828" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O(C1=C2C(=C(C=C1OC)NC(CCCN)C)N=C(C=C2C)OC)C3=CC(C(F)(F)F)=CC=C3" xsd:string + +[Term] +id: CHEBI:141488 +name: (R)-tafenoquine +namespace: chebi_ontology +def: "A N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine that has R configuration." [] +subset: 3_STAR +is_a: CHEBI:141487 ! N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine +relationship: is_enantiomer_of CHEBI:141489 ! (S)-tafenoquine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H28F3N3O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3/t15-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LBHLFPGPEGDCJG-OAHLLOKOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "463.494" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "463.20828" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O(C1=C2C(=C(C=C1OC)N[C@@H](CCCN)C)N=C(C=C2C)OC)C3=CC(C(F)(F)F)=CC=C3" xsd:string + +[Term] +id: CHEBI:141489 +name: (S)-tafenoquine +namespace: chebi_ontology +def: "A N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine that has S configuration." [] +subset: 3_STAR +is_a: CHEBI:141487 ! N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine +relationship: is_enantiomer_of CHEBI:141488 ! (R)-tafenoquine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H28F3N3O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LBHLFPGPEGDCJG-HNNXBMFYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "463.494" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "463.20828" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O(C1=C2C(=C(C=C1OC)N[C@H](CCCN)C)N=C(C=C2C)OC)C3=CC(C(F)(F)F)=CC=C3" xsd:string + [Term] id: CHEBI:142163 name: 24G7 epitope @@ -622,6 +1778,116 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "134.136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.04801" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*" xsd:string +[Term] +id: CHEBI:142348 +name: hexahydronaphthalenes +namespace: chebi_ontology +def: "Any carbobycyclic compound that is an hexahydronaphthalene or a compound obtained from an hexahydronaphthalene by formal substitution of one or more hydrogens." [] +subset: 3_STAR +is_a: CHEBI:36785 ! carbobicyclic compound + +[Term] +id: CHEBI:142513 +name: oxime anion +namespace: chebi_ontology +def: "A organic ion resulting from the deprotonation of the hydroxy group of any oxime." [] +subset: 3_STAR +synonym: "oximate" RELATED [ChEBI] +synonym: "oximates" RELATED [ChEBI] +synonym: "oxime anion" EXACT [ChEBI] +synonym: "oxime anions" RELATED [ChEBI] +is_a: CHEBI:25696 ! organic anion +relationship: is_conjugate_base_of CHEBI:25750 ! oxime +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CNO" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "42.017" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(*)(=N[O-])*" xsd:string + +[Term] +id: CHEBI:142544 +name: tamsulosin(1+) +namespace: chebi_ontology +def: "A secondary ammonium ion resulting from the protonation of the secondary amino group of tamsulosin. The major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2R)-N-[2-(2-ethoxyphenoxy)ethyl]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-aminium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:137419 ! secondary ammonium ion +relationship: is_conjugate_acid_of CHEBI:9398 ! tamsulosin +relationship: is_enantiomer_of CHEBI:142549 ! ent-tamsulosin(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H29N2O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/p+1/t15-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRHKJLXJIQTDTD-OAHLLOKOSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "409.522" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "409.17917" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(OCC[NH2+][C@@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC" xsd:string + +[Term] +id: CHEBI:142546 +name: 5-(2-\{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide +namespace: chebi_ontology +def: "A secondary amino compound that is ammonia in which nitrogen is substituted by a 1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl group and a 2-(2-ethoxyphenoxy)ethyl group." [] +subset: 3_STAR +synonym: "5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "5-(2-{[2-(o-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide" RELATED [ChEBI] +xref: PMID:2891044 {source="Europe PMC"} +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:50995 ! secondary amino compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H28N2O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRHKJLXJIQTDTD-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "408.514" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "408.17189" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(OCCNC(CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC" xsd:string + +[Term] +id: CHEBI:142548 +name: ent-tamsulosin +namespace: chebi_ontology +def: "A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (S)-configuration. The enantiomer of tamsulosin." [] +subset: 3_STAR +synonym: "(+)-tamsulosin" RELATED [ChEBI] +synonym: "(S)-(+)-tamsulosin" RELATED [ChEBI] +synonym: "(S)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide" RELATED [ChEBI] +synonym: "(S)-tamsulosin" RELATED [ChemIDplus] +xref: CAS:106138-88-9 {source="ChemIDplus"} +xref: PMID:2891044 {source="Europe PMC"} +xref: Reaxys:6896058 {source="Reaxys"} +is_a: CHEBI:142546 ! 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide +relationship: is_conjugate_base_of CHEBI:142549 ! ent-tamsulosin(1+) +relationship: is_enantiomer_of CHEBI:9398 ! tamsulosin +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H28N2O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRHKJLXJIQTDTD-HNNXBMFYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "408.514" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "408.17189" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(OCCN[C@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC" xsd:string + +[Term] +id: CHEBI:142549 +name: ent-tamsulosin(1+) +namespace: chebi_ontology +def: "A secondary ammonium ion resulting from the secondary amino group of ent-tamsulosin. The major species at pH 7.3." [] +subset: 3_STAR +synonym: "(+)-tamsulosin(1+)" RELATED [ChEBI] +synonym: "(2S)-N-[2-(2-ethoxyphenoxy)ethyl]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-aminium" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-(+)-tamsulosin(1+)" RELATED [ChEBI] +synonym: "(S)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide(1+)" RELATED [ChEBI] +synonym: "(S)-tamsulosin(1+)" RELATED [ChEBI] +is_a: CHEBI:137419 ! secondary ammonium ion +relationship: is_conjugate_acid_of CHEBI:142548 ! ent-tamsulosin +relationship: is_enantiomer_of CHEBI:142544 ! tamsulosin(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H29N2O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/p+1/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRHKJLXJIQTDTD-HNNXBMFYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "409.522" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "409.17917" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(OCC[NH2+][C@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC" xsd:string + [Term] id: CHEBI:14321 name: glutamate(1-) @@ -646,6 +1912,51 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "146.12136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "146.04588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CCC([O-])=O)C([O-])=O" xsd:string +[Term] +id: CHEBI:143658 +name: vincristine(2+) +namespace: chebi_ontology +def: "A vinca alkaloid cation resulting from the protonation of the two tertiary amino groups of vincristine. Major species at pH 7.3." [] +subset: 3_STAR +synonym: "vincristine" RELATED [UniProt] +is_a: CHEBI:60082 ! vinca alkaloid cation +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: is_conjugate_acid_of CHEBI:28445 ! vincristine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H58N4O10" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/p+2/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OGWKCGZFUXNPDA-XQKSVPLYSA-P" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "826.987" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "826.41420" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C(=CC2=C1N([C@@]3([C@@]24[C@@]5([C@]([C@H]([C@]3(O)C(=O)OC)OC(C)=O)(C=CC[NH+]5CC4)CC)[H])[H])C=O)[C@@]6(C=7NC8=CC=CC=C8C7CC[NH+]9C[C@](C[C@@H](C9)C6)(O)CC)C(OC)=O)OC" xsd:string + +[Term] +id: CHEBI:145047 +name: antispermatogenic agent +namespace: chebi_ontology +def: "An agent that destroy spermatozoa in the male genitalia and block spermatogenesis." [] +subset: 3_STAR +synonym: "antispermatogenic" RELATED [ChEBI] +synonym: "antispermatogenic agents" RELATED [ChEBI] +synonym: "antispermatogenics" RELATED [ChEBI] +xref: PMID:16371305 {source="Europe PMC"} +is_a: CHEBI:33232 ! application + +[Term] +id: CHEBI:145565 +name: macrolide lactam +namespace: chebi_ontology +def: "A macrolide in which the macrocyclic lactone ring includes an amide group." [] +subset: 3_STAR +synonym: "macrolide lactams" RELATED [ChEBI] +xref: PMID:11678663 {source="Europe PMC"} +xref: PMID:12227772 {source="Europe PMC"} +xref: PMID:15248618 {source="Europe PMC"} +xref: PMID:17378533 {source="Europe PMC"} +xref: PMID:31226284 {source="Europe PMC"} +is_a: CHEBI:24995 ! lactam +is_a: CHEBI:25106 ! macrolide + [Term] id: CHEBI:145810 name: insulin @@ -662,6 +1973,97 @@ is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:25905 ! peptide hormone +[Term] +id: CHEBI:145932 +name: (S)-2-methylbutanoate +namespace: chebi_ontology +def: "A branched-chain saturated fatty acid anion resulting from the deprotonation of the carboxy group of (S)-2-methylbutanoic acid. The major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2S)-2-methylbutanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "(2S)-2-methylbutyrate" RELATED [ChEBI] +synonym: "(2S)-2-methylbutyric acid anion" RELATED [ChEBI] +synonym: "(S)-2-methylbutanoate" EXACT [UniProt] +synonym: "(S)-2-methylbutyrate" RELATED [ChEBI] +synonym: "(S)-alpha-methylbutyrate" RELATED [ChEBI] +xref: PMID:16819884 {source="Europe PMC"} +is_a: CHEBI:58951 ! short-chain fatty acid anion +is_a: CHEBI:58956 ! branched-chain saturated fatty acid anion +is_a: CHEBI:83976 ! 2-methyl fatty acid anion +relationship: is_conjugate_base_of CHEBI:38655 ! (S)-2-methylbutyric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/p-1/t4-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLAMNBDJUVNPJU-BYPYZUCNSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "101.126" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.06080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([C@H](CC)C)=O" xsd:string + +[Term] +id: CHEBI:149504 +name: losartan(1-) +namespace: chebi_ontology +def: "An organic anion that is the conjugate base of losartan, obtained from the deprotonation of the tetrazole NH group. Major species at pH 7.3." [] +subset: 3_STAR +synonym: "5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}[biphenyl]-2-yl)tetrazol-1-ide" EXACT IUPAC_NAME [IUPAC] +synonym: "losartan" RELATED [UniProt] +xref: PMID:18674515 {source="SUBMITTER"} +is_a: CHEBI:25696 ! organic anion +relationship: is_conjugate_base_of CHEBI:6541 ! losartan +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H22ClN6O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H22ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3/q-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MDMTUGIZSFHDIC-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "421.910" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "421.15491" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(CN2C(=NC(=C2CO)Cl)CCCC)=CC=C1C3=CC=CC=C3C=4[N-]N=NN4" xsd:string + +[Term] +id: CHEBI:149509 +name: candesartan(2-) +namespace: chebi_ontology +def: "A monocarboxylic acid anion resulting from the deprotonation of the tetrazole NH group and carboxy group of candesartan. It is the major species at pH 7.3." [] +subset: 3_STAR +synonym: "2-ethoxy-1-{[2'-(tetrazol-1-id-5-yl)[biphenyl]-4-yl]methyl}-1H-benzimidazole-7-carboxylate" EXACT IUPAC_NAME [IUPAC] +synonym: "candesartan" RELATED [UniProt] +xref: PMID:18674515 {source="SUBMITTER"} +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:3347 ! candesartan +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H18N6O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H2,26,27,28,29,31,32)/p-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BSLSLQSFLOCXQQ-UHFFFAOYSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "438.448" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "438.14514" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=CC=C(C=C1)CN2C3=C(C(=O)[O-])C=CC=C3N=C2OCC)C=4C=CC=CC4C5=NN=N[N-]5" xsd:string + +[Term] +id: CHEBI:149552 +name: emetic +def: "Any agent that induces nausea and vomiting." [] +synonym: "emetics" RELATED [] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:149553 +name: anticoronaviral agent +namespace: chebi_ontology +def: "Any antiviral agent which inhibits the activity of coronaviruses." [] +subset: 3_STAR +synonym: "anti-coronaviral agent" RELATED [ChEBI] +synonym: "anti-coronaviral agents" RELATED [ChEBI] +synonym: "anti-coronavirus agent" RELATED [ChEBI] +synonym: "anti-coronavirus agents" RELATED [ChEBI] +synonym: "anticoronaviral agent" EXACT [ChEBI] +synonym: "anticoronaviral agents" RELATED [ChEBI] +synonym: "anticoronaviral drug" RELATED [ChEBI] +synonym: "anticoronaviral drugs" RELATED [ChEBI] +synonym: "anticoronavirus agent" RELATED [ChEBI] +synonym: "anticoronavirus agents" RELATED [ChEBI] +synonym: "anticoronviral agent" RELATED [ChEBI] +synonym: "anticoronviral agents" RELATED [ChEBI] +xref: Wikipedia:Coronavirus +is_a: CHEBI:22587 ! antiviral agent + [Term] id: CHEBI:15138 name: sulfide(2-) @@ -885,6 +2287,95 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "121.15922" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.01975" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CS)C(O)=O" xsd:string +[Term] +id: CHEBI:15365 +name: acetylsalicylic acid +namespace: chebi_ontology +alt_id: CHEBI:22188 +alt_id: CHEBI:22203 +alt_id: CHEBI:2890 +alt_id: CHEBI:40705 +alt_id: CHEBI:71414 +def: "A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity." [] +subset: 3_STAR +synonym: "2-(ACETYLOXY)BENZOIC ACID" RELATED [PDBeChem] +synonym: "2-(acetyloxy)benzoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "2-Acetoxybenzenecarboxylic acid" RELATED [KEGG_COMPOUND] +synonym: "2-acetoxybenzoic acid" RELATED [ChemIDplus] +synonym: "Acetylsalicylate" RELATED [KEGG_COMPOUND] +synonym: "Acetylsalicylic acid" EXACT [KEGG_COMPOUND] +synonym: "Acetylsalicylsaeure" RELATED [ChemIDplus] +synonym: "acide 2-(acetyloxy)benzoique" RELATED [IUPAC] +synonym: "acide acetylsalicylique" RELATED INN [ChemIDplus] +synonym: "acido acetilsalicilico" RELATED INN [NIST_Chemistry_WebBook] +synonym: "acidum acetylsalicylicum" RELATED INN [NIST_Chemistry_WebBook] +synonym: "ASA" RELATED [ChemIDplus] +synonym: "Aspirin" RELATED [KEGG_COMPOUND] +synonym: "Azetylsalizylsaeure" RELATED [ChEBI] +synonym: "Easprin" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "o-acetoxybenzoic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "O-acetylsalicylic acid" RELATED [ChemIDplus] +synonym: "o-carboxyphenyl acetate" RELATED [NIST_Chemistry_WebBook] +synonym: "salicylic acid acetate" RELATED [ChemIDplus] +xref: Beilstein:779271 {source="Beilstein"} +xref: CAS:50-78-2 {source="ChemIDplus"} +xref: CAS:50-78-2 {source="NIST Chemistry WebBook"} +xref: CAS:50-78-2 {source="KEGG COMPOUND"} +xref: Drug_Central:74 {source="DrugCentral"} +xref: DrugBank:DB00945 +xref: Gmelin:218864 {source="Gmelin"} +xref: HMDB:HMDB0001879 +xref: KEGG:C01405 +xref: KEGG:D00109 +xref: LINCS:LSM-5288 +xref: MetaCyc:CPD-524 +xref: PDBeChem:AIN +xref: PMID:11203441 {source="Europe PMC"} +xref: PMID:11402787 {source="Europe PMC"} +xref: PMID:11597554 {source="Europe PMC"} +xref: PMID:11733186 {source="Europe PMC"} +xref: PMID:12852484 {source="Europe PMC"} +xref: PMID:14753751 {source="Europe PMC"} +xref: PMID:15542410 {source="Europe PMC"} +xref: PMID:15590729 {source="Europe PMC"} +xref: PMID:1650428 {source="Europe PMC"} +xref: PMID:18226435 {source="Europe PMC"} +xref: PMID:18335236 {source="Europe PMC"} +xref: PMID:18631321 {source="Europe PMC"} +xref: PMID:19010312 {source="Europe PMC"} +xref: PMID:19386367 {source="Europe PMC"} +xref: PMID:19706045 {source="Europe PMC"} +xref: PMID:21699808 {source="Europe PMC"} +xref: PMID:22866967 {source="Europe PMC"} +xref: PMID:445303 {source="Europe PMC"} +xref: Reaxys:779271 {source="Reaxys"} +xref: Wikipedia:Aspirin +is_a: CHEBI:140310 ! phenyl acetates +is_a: CHEBI:22723 ! benzoic acids +is_a: CHEBI:26596 ! salicylates +relationship: has_functional_parent CHEBI:16914 ! salicylic acid +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35493 ! antipyretic +relationship: has_role CHEBI:49023 ! prostaglandin antagonist +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50427 ! platelet aggregation inhibitor +relationship: has_role CHEBI:50629 ! cyclooxygenase 2 inhibitor +relationship: has_role CHEBI:50630 ! cyclooxygenase 1 inhibitor +relationship: has_role CHEBI:50905 ! teratogenic agent +relationship: has_role CHEBI:73182 ! plant activator +relationship: has_role CHEBI:77425 ! EC 1.1.1.188 (prostaglandin-F synthase) inhibitor +relationship: has_role CHEBI:88188 ! drug allergen +relationship: is_conjugate_acid_of CHEBI:13719 ! acetylsalicylate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H8O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BSYNRYMUTXBXSQ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15740" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.04226" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)Oc1ccccc1C(O)=O" xsd:string + [Term] id: CHEBI:15366 name: acetic acid @@ -940,6 +2431,7 @@ xref: PPDB:1333 xref: Reaxys:506007 {source="Reaxys"} xref: Wikipedia:Acetic_acid is_a: CHEBI:25384 ! monocarboxylic acid +is_a: FOODON:03412972 ! food additive relationship: has_role CHEBI:48356 ! protic solvent relationship: has_role CHEBI:64049 ! food acidity regulator relationship: has_role CHEBI:65256 ! antimicrobial food preservative @@ -1226,6 +2718,22 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "75.06664" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "75.03203" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCC(O)=O" xsd:string +[Term] +id: CHEBI:15440 +name: squalene +def: "A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration." [] +synonym: "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene" EXACT [] +synonym: "(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene" RELATED [] +synonym: "Spinacene" RELATED [] +synonym: "Squalene" EXACT [] +synonym: "squalene" EXACT [] +synonym: "Supraene" RELATED [] +is_a: CHEBI:35191 ! triterpene +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:77746 ! human metabolite + [Term] id: CHEBI:155837 name: tripeptide zwitterion @@ -1245,6 +2753,14 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "186.146" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "186.05148" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)([C@@H]([NH3+])*)N[C@H](C(=O)N[C@H](C(=O)[O-])*)*" xsd:string +[Term] +id: CHEBI:156473 +name: cyclobutanes +namespace: chebi_ontology +def: "Cyclobutane and its derivatives formed by substitution." [] +subset: 3_STAR +is_a: CHEBI:33598 ! carbocyclic compound + [Term] id: CHEBI:15693 name: aldose @@ -1424,6 +2940,47 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "275.450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "275.23749" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)O)C" xsd:string +[Term] +id: CHEBI:15903 +name: beta-D-glucose +namespace: chebi_ontology +alt_id: CHEBI:10397 +alt_id: CHEBI:12373 +alt_id: CHEBI:22795 +alt_id: CHEBI:41140 +def: "D-Glucopyranose with beta configuration at the anomeric centre." [] +subset: 3_STAR +synonym: "beta-D-glucopyranose" EXACT IUPAC_NAME [IUPAC] +synonym: "BETA-D-GLUCOSE" EXACT [PDBeChem] +synonym: "beta-D-Glucose" EXACT [KEGG_COMPOUND] +synonym: "beta-D-glucose" EXACT [UniProt] +synonym: "WURCS=2.0/1,1,0/[a2122h-1b_1-5]/1/" RELATED [GlyTouCan] +xref: Beilstein:1281607 {source="Beilstein"} +xref: CAS:492-61-5 {source="NIST Chemistry WebBook"} +xref: CAS:492-61-5 {source="ChemIDplus"} +xref: CAS:492-61-5 {source="KEGG COMPOUND"} +xref: Drug_Central:845 {source="DrugCentral"} +xref: DrugBank:DB02379 +xref: GlyGen:G71142DF +xref: GlyTouCan:G71142DF +xref: Gmelin:648637 {source="Gmelin"} +xref: KEGG:C00221 +xref: PDBeChem:BGC +xref: PMID:19443021 {source="Europe PMC"} +xref: PMID:25568069 {source="Europe PMC"} +xref: PMID:31537530 {source="Europe PMC"} +xref: Reaxys:1281607 {source="Reaxys"} +is_a: CHEBI:4167 ! D-glucopyranose +relationship: has_role CHEBI:53000 ! epitope +relationship: is_enantiomer_of CHEBI:37631 ! beta-L-glucose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-VFUOTHLCSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string + [Term] id: CHEBI:15904 name: long-chain fatty acid @@ -1606,6 +3163,55 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "147.12930" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "147.05316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](CCC(O)=O)C(O)=O" xsd:string +[Term] +id: CHEBI:16040 +name: cytosine +namespace: chebi_ontology +alt_id: CHEBI:14066 +alt_id: CHEBI:23531 +alt_id: CHEBI:4072 +alt_id: CHEBI:41732 +def: "An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4." [] +subset: 3_STAR +synonym: "4-amino-2(1H)-pyrimidinone" RELATED [NIST_Chemistry_WebBook] +synonym: "4-amino-2-hydroxypyrimidine" RELATED [NIST_Chemistry_WebBook] +synonym: "4-aminopyrimidin-2(1H)-one" EXACT IUPAC_NAME [IUPAC] +synonym: "C" RELATED [ChEBI] +synonym: "Cyt" RELATED [CBN] +synonym: "Cytosin" RELATED [ChEBI] +synonym: "Cytosine" EXACT [KEGG_COMPOUND] +synonym: "cytosine" EXACT [UniProt] +synonym: "Zytosin" RELATED [ChEBI] +xref: Beilstein:2637 {source="Beilstein"} +xref: CAS:71-30-7 {source="KEGG COMPOUND"} +xref: CAS:71-30-7 {source="NIST Chemistry WebBook"} +xref: CAS:71-30-7 {source="ChemIDplus"} +xref: Gmelin:82472 {source="Gmelin"} +xref: HMDB:HMDB0000630 +xref: KEGG:C00380 +xref: KNApSAcK:C00001498 +xref: MetaCyc:CYTOSINE +xref: PDBeChem:CYT +xref: PMID:14253484 {source="Europe PMC"} +xref: PMID:22770225 {source="Europe PMC"} +xref: PMID:7877593 {source="Europe PMC"} +xref: Reaxys:2637 {source="Reaxys"} +xref: Wikipedia:Cytosine +is_a: CHEBI:26432 ! pyrimidine nucleobase +is_a: CHEBI:38337 ! pyrimidone +is_a: CHEBI:38338 ! aminopyrimidine +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H5N3O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OPTASPLRGRRNAP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "111.10212" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "111.04326" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1cc[nH]c(=O)n1" xsd:string + [Term] id: CHEBI:16042 name: halide anion @@ -1938,6 +3544,114 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "34.08188" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "33.98772" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S[H]" xsd:string +[Term] +id: CHEBI:16137 +name: chondroitin D-glucuronate +def: "A mucopolysaccharide composed of repeating beta-D-glucopyranuronosyl-(1->3)-beta-D-N-acetylgalactosaminyl units." [] +synonym: "Chondroitin" RELATED [] +synonym: "Chondroitin-D-glucuronate" RELATED [] +is_a: CHEBI:37395 ! mucopolysaccharide +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: is_conjugate_acid_of CHEBI:57652 ! chondroitin D-glucuronate anion + +[Term] +id: CHEBI:16150 +name: benzoate +namespace: chebi_ontology +alt_id: CHEBI:13879 +alt_id: CHEBI:22717 +def: "The simplest member of the class of benzoates that is the conjugate base of benzoic acid, comprising a benzoic acid core with a proton missing to give a charge of -1." [] +subset: 3_STAR +synonym: "Benzenecarboxylate" RELATED [HMDB] +synonym: "Benzeneformate" RELATED [HMDB] +synonym: "Benzenemethanoate" RELATED [HMDB] +synonym: "benzoate" EXACT IUPAC_NAME [IUPAC] +synonym: "benzoate" EXACT [UniProt] +synonym: "benzoate anion" RELATED [NIST_Chemistry_WebBook] +synonym: "benzoic acid, ion(1-)" RELATED [ChemIDplus] +synonym: "Phenylcarboxylate" RELATED [HMDB] +synonym: "Phenylformate" RELATED [HMDB] +xref: Beilstein:1862486 {source="Beilstein"} +xref: CAS:766-76-7 {source="NIST Chemistry WebBook"} +xref: CAS:766-76-7 {source="ChemIDplus"} +xref: Gmelin:2945 {source="Gmelin"} +xref: HMDB:HMDB0001870 +xref: KEGG:C00180 +xref: MetaCyc:BENZOATE +xref: Reaxys:1862486 {source="Reaxys"} +xref: UM-BBD_compID:c0121 {source="UM-BBD"} +is_a: CHEBI:22718 ! benzoates +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76967 ! human xenobiotic metabolite +relationship: is_conjugate_base_of CHEBI:30746 ! benzoic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WPYMKLBDIGXBTP-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "121.11340" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.02950" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)c1ccccc1" xsd:string + +[Term] +id: CHEBI:16183 +name: methane +namespace: chebi_ontology +alt_id: CHEBI:14585 +alt_id: CHEBI:25220 +alt_id: CHEBI:6811 +def: "A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC)." [] +subset: 3_STAR +synonym: "CH4" RELATED [IUPAC] +synonym: "marsh gas" RELATED [NIST_Chemistry_WebBook] +synonym: "metano" RELATED [ChEBI] +synonym: "Methan" RELATED [ChEBI] +synonym: "Methane" EXACT [KEGG_COMPOUND] +synonym: "methane" EXACT IUPAC_NAME [IUPAC] +synonym: "methane" EXACT [UniProt] +synonym: "methane" EXACT [ChEBI] +synonym: "methyl hydride" RELATED [ChemIDplus] +synonym: "tetrahydridocarbon" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1718732 {source="ChemIDplus"} +xref: CAS:74-82-8 {source="NIST Chemistry WebBook"} +xref: CAS:74-82-8 {source="ChemIDplus"} +xref: CAS:74-82-8 {source="KEGG COMPOUND"} +xref: Gmelin:59 {source="Gmelin"} +xref: HMDB:HMDB0002714 +xref: KEGG:C01438 +xref: MetaCyc:CH4 +xref: Patent:FR994032 +xref: Patent:US2583090 +xref: PMID:17791569 {source="Europe PMC"} +xref: PMID:23104415 {source="Europe PMC"} +xref: PMID:23353606 {source="Europe PMC"} +xref: PMID:23376302 {source="Europe PMC"} +xref: PMID:23397538 {source="Europe PMC"} +xref: PMID:23718889 {source="Europe PMC"} +xref: PMID:23739479 {source="Europe PMC"} +xref: PMID:23742231 {source="Europe PMC"} +xref: PMID:23756351 {source="Europe PMC"} +xref: PMID:24132456 {source="Europe PMC"} +xref: PMID:24161402 {source="Europe PMC"} +xref: PMID:24259373 {source="Europe PMC"} +xref: Reaxys:1718732 {source="Reaxys"} +xref: UM-BBD_compID:c0095 {source="UM-BBD"} +xref: Wikipedia:Methane +is_a: CHEBI:138675 ! gas molecular entity +is_a: CHEBI:18310 ! alkane +is_a: CHEBI:37176 ! mononuclear parent hydride +is_a: CHEBI:64708 ! one-carbon compound +relationship: has_role CHEBI:35230 ! fossil fuel +relationship: has_role CHEBI:76413 ! greenhouse gas +relationship: has_role CHEBI:76969 ! bacterial metabolite +relationship: is_conjugate_acid_of CHEBI:29438 ! methanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH4/h1H4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VNWKTOKETHGBQD-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "16.04246" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.03130" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([H])([H])[H]" xsd:string + [Term] id: CHEBI:16189 name: sulfate @@ -2154,10 +3868,16 @@ synonym: "hydroxyethane" RELATED [ChemIDplus] synonym: "Methylcarbinol" RELATED [KEGG_COMPOUND] synonym: "spiritus vini" RELATED [ChEBI] xref: Beilstein:1718733 "Beilstein" -xref: CAS:64-17-5 "NIST Chemistry WebBook" +xref: Beilstein:1718733 {source="Beilstein"} +xref: CAS:64-17-5 "KEGG COMPOUND" +xref: CAS:64-17-5 {source="ChemIDplus"} +xref: CAS:64-17-5 {source="NIST Chemistry WebBook"} +xref: CAS:64-17-5 {source="KEGG COMPOUND"} xref: Drug_Central:1076 "DrugCentral" +xref: Drug_Central:1076 {source="DrugCentral"} xref: DrugBank:DB00898 xref: Gmelin:787 "Gmelin" +xref: Gmelin:787 {source="Gmelin"} xref: HMDB:HMDB0000108 xref: KEGG:C00469 xref: KEGG:D00068 @@ -2168,73 +3888,141 @@ xref: MolBase:858 xref: MolBase:859 xref: PDBeChem:EOH xref: PMID:11046114 "Europe PMC" +xref: PMID:11046114 {source="Europe PMC"} xref: PMID:11090978 "Europe PMC" +xref: PMID:11090978 {source="Europe PMC"} xref: PMID:11198720 "Europe PMC" +xref: PMID:11198720 {source="Europe PMC"} xref: PMID:11200745 "Europe PMC" +xref: PMID:11200745 {source="Europe PMC"} xref: PMID:11262320 "Europe PMC" +xref: PMID:11262320 {source="Europe PMC"} xref: PMID:11303910 "Europe PMC" +xref: PMID:11303910 {source="Europe PMC"} xref: PMID:11333032 "Europe PMC" +xref: PMID:11333032 {source="Europe PMC"} xref: PMID:11505026 "Europe PMC" +xref: PMID:11505026 {source="Europe PMC"} xref: PMID:11590970 "Europe PMC" +xref: PMID:11590970 {source="Europe PMC"} xref: PMID:11728426 "Europe PMC" +xref: PMID:11728426 {source="Europe PMC"} xref: PMID:11750186 "Europe PMC" +xref: PMID:11750186 {source="Europe PMC"} xref: PMID:11754521 "Europe PMC" +xref: PMID:11754521 {source="Europe PMC"} xref: PMID:11810019 "Europe PMC" +xref: PMID:11810019 {source="Europe PMC"} xref: PMID:11826039 "Europe PMC" +xref: PMID:11826039 {source="Europe PMC"} xref: PMID:11981228 "Europe PMC" +xref: PMID:11981228 {source="Europe PMC"} xref: PMID:12824058 "Europe PMC" +xref: PMID:12824058 {source="Europe PMC"} xref: PMID:12829422 "Europe PMC" +xref: PMID:12829422 {source="Europe PMC"} xref: PMID:12888778 "Europe PMC" +xref: PMID:12888778 {source="Europe PMC"} xref: PMID:12946583 "Europe PMC" +xref: PMID:12946583 {source="Europe PMC"} xref: PMID:14674846 "Europe PMC" +xref: PMID:14674846 {source="Europe PMC"} xref: PMID:15019421 "Europe PMC" +xref: PMID:15019421 {source="Europe PMC"} xref: PMID:15239123 "Europe PMC" +xref: PMID:15239123 {source="Europe PMC"} xref: PMID:15285839 "Europe PMC" +xref: PMID:15285839 {source="Europe PMC"} xref: PMID:15464411 "Europe PMC" +xref: PMID:15464411 {source="Europe PMC"} xref: PMID:15465973 "Europe PMC" +xref: PMID:15465973 {source="Europe PMC"} xref: PMID:15749123 "Europe PMC" +xref: PMID:15749123 {source="Europe PMC"} xref: PMID:15900217 "Europe PMC" +xref: PMID:15900217 {source="Europe PMC"} xref: PMID:15902919 "Europe PMC" +xref: PMID:15902919 {source="Europe PMC"} xref: PMID:16084479 "Europe PMC" +xref: PMID:16084479 {source="Europe PMC"} xref: PMID:16133132 "Europe PMC" +xref: PMID:16133132 {source="Europe PMC"} xref: PMID:16352430 "Europe PMC" +xref: PMID:16352430 {source="Europe PMC"} xref: PMID:16390872 "Europe PMC" +xref: PMID:16390872 {source="Europe PMC"} xref: PMID:16737463 "Europe PMC" +xref: PMID:16737463 {source="Europe PMC"} xref: PMID:16891664 "Europe PMC" +xref: PMID:16891664 {source="Europe PMC"} xref: PMID:16934862 "Europe PMC" +xref: PMID:16934862 {source="Europe PMC"} xref: PMID:17043811 "Europe PMC" +xref: PMID:17043811 {source="Europe PMC"} xref: PMID:17190852 "Europe PMC" +xref: PMID:17190852 {source="Europe PMC"} xref: PMID:17663926 "Europe PMC" +xref: PMID:17663926 {source="Europe PMC"} xref: PMID:17687877 "Europe PMC" +xref: PMID:17687877 {source="Europe PMC"} xref: PMID:18095657 "Europe PMC" +xref: PMID:18095657 {source="Europe PMC"} xref: PMID:18249266 "Europe PMC" +xref: PMID:18249266 {source="Europe PMC"} xref: PMID:18320157 "Europe PMC" +xref: PMID:18320157 {source="Europe PMC"} xref: PMID:18347649 "Europe PMC" +xref: PMID:18347649 {source="Europe PMC"} xref: PMID:18408978 "Europe PMC" +xref: PMID:18408978 {source="Europe PMC"} xref: PMID:18411066 "Europe PMC" +xref: PMID:18411066 {source="Europe PMC"} xref: PMID:18456322 "Europe PMC" +xref: PMID:18456322 {source="Europe PMC"} xref: PMID:18513832 "Europe PMC" +xref: PMID:18513832 {source="Europe PMC"} xref: PMID:18922656 "Europe PMC" +xref: PMID:18922656 {source="Europe PMC"} xref: PMID:18925476 "Europe PMC" +xref: PMID:18925476 {source="Europe PMC"} xref: PMID:19280886 "Europe PMC" +xref: PMID:19280886 {source="Europe PMC"} xref: PMID:19359288 "Europe PMC" +xref: PMID:19359288 {source="Europe PMC"} xref: PMID:19384566 "Europe PMC" +xref: PMID:19384566 {source="Europe PMC"} xref: PMID:19458312 "Europe PMC" +xref: PMID:19458312 {source="Europe PMC"} xref: PMID:19851413 "Europe PMC" +xref: PMID:19851413 {source="Europe PMC"} xref: PMID:19901811 "Europe PMC" +xref: PMID:19901811 {source="Europe PMC"} xref: PMID:21600756 "Europe PMC" +xref: PMID:21600756 {source="Europe PMC"} xref: PMID:21762181 "Europe PMC" +xref: PMID:21762181 {source="Europe PMC"} xref: PMID:21881875 "Europe PMC" +xref: PMID:21881875 {source="Europe PMC"} xref: PMID:21967628 "Europe PMC" +xref: PMID:21967628 {source="Europe PMC"} xref: PMID:22019193 "Europe PMC" +xref: PMID:22019193 {source="Europe PMC"} xref: PMID:22222864 "Europe PMC" +xref: PMID:22222864 {source="Europe PMC"} xref: PMID:22261437 "Europe PMC" +xref: PMID:22261437 {source="Europe PMC"} xref: PMID:22286266 "Europe PMC" +xref: PMID:22286266 {source="Europe PMC"} xref: PMID:22306018 "Europe PMC" +xref: PMID:22306018 {source="Europe PMC"} xref: PMID:22331491 "Europe PMC" +xref: PMID:22331491 {source="Europe PMC"} xref: PMID:22336593 "Europe PMC" +xref: PMID:22336593 {source="Europe PMC"} xref: PPDB:1373 +xref: Reaxys:1718733 {source="Reaxys"} xref: Reaxys:1718733 "Reaxys" +xref: UM-BBD_compID:c0038 {source="UM-BBD"} xref: UM-BBD_compID:c0038 "UM-BBD" xref: Wikipedia:Ethanol is_a: CHEBI:134179 ! volatile organic compound @@ -2425,6 +4213,29 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "121.15922" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.01975" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](CS)C(O)=O" xsd:string +[Term] +id: CHEBI:16385 +name: organic sulfide +namespace: chebi_ontology +alt_id: CHEBI:13694 +alt_id: CHEBI:26960 +alt_id: CHEBI:9340 +def: "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." [] +subset: 3_STAR +synonym: "organic sulfides" RELATED [ChEBI] +synonym: "RSR" RELATED [IUPAC] +synonym: "Sulfide" RELATED [KEGG_COMPOUND] +synonym: "sulfides" EXACT IUPAC_NAME [IUPAC] +synonym: "Thioether" RELATED [KEGG_COMPOUND] +synonym: "thioethers" RELATED [IUPAC] +xref: KEGG:C00297 +is_a: CHEBI:26822 ! sulfide +is_a: CHEBI:33261 ! organosulfur compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "SR2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "32.066" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string + [Term] id: CHEBI:16393 name: sphingosine @@ -2553,6 +4364,7 @@ xref: Wikipedia:Carbon_dioxide is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:23014 ! carbon oxide is_a: CHEBI:64708 ! one-carbon compound +is_a: FOODON:03412972 ! food additive relationship: has_role CHEBI:35620 ! vasodilator agent relationship: has_role CHEBI:38867 ! anaesthetic relationship: has_role CHEBI:46787 ! solvent @@ -2580,6 +4392,7 @@ namespace: chebi_ontology alt_id: CHEBI:8526 def: "A naturally occurring polypeptide synthesized at the ribosome." [] subset: 3_STAR +synonym: "a protein" RELATED [UniProt] synonym: "polypeptide chain" RELATED [ChEBI] synonym: "Protein" RELATED [KEGG_COMPOUND] synonym: "protein polypeptide chains" RELATED [ChEBI] @@ -2596,6 +4409,7 @@ alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] subset: 3_STAR +synonym: "a carbohydrate" RELATED [UniProt] synonym: "carbohidrato" RELATED [IUPAC] synonym: "carbohidratos" RELATED [IUPAC] synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC] @@ -2685,6 +4499,20 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "170.187" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "170.08117" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(=CC(=C1O)O)C(C[NH3+])O" xsd:string +[Term] +id: CHEBI:167095 +name: secondary fatty alcohol +namespace: chebi_ontology +def: "A fatty alcohol consisting of a chain of 3 to greater than 27 carbon atoms in which a hydroxy group is attached to a saturated carbon atom different from the terminal carbons. Secondary fatty alcohols may be saturated or unsaturated and may be branched or unbranched." [] +subset: 2_STAR +synonym: "a secondary fatty alcohol" RELATED [UniProt] +is_a: CHEBI:24026 ! fatty alcohol +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2OR2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "30.026" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.01056" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(O)*" xsd:string + [Term] id: CHEBI:16716 name: benzene @@ -2904,6 +4732,27 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "160.21570" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "160.10005" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCc1c[nH]c2ccccc12" xsd:string +[Term] +id: CHEBI:16799 +name: 16alpha-hydroxy steroid +namespace: chebi_ontology +alt_id: CHEBI:11333 +alt_id: CHEBI:13584 +alt_id: CHEBI:19165 +alt_id: CHEBI:778 +def: "A 16-hydroxy steroid in which the hydroxy group at position 16 has alpha-configuration." [] +subset: 3_STAR +synonym: "16alpha-hydroxy steroids" RELATED [ChEBI] +synonym: "16alpha-Hydroxysteroid" RELATED [KEGG_COMPOUND] +synonym: "a 16alpha-hydroxysteroid" RELATED [UniProt] +xref: KEGG:C01090 +is_a: CHEBI:36840 ! 16-hydroxy steroid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31OR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "275.450" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "275.23749" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C([C@@H](C3)O)*)(C)CC1)CCC4C2(CCCC4)C" xsd:string + [Term] id: CHEBI:16827 name: corticosterone @@ -2958,6 +4807,65 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "346.46050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "346.21441" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO" xsd:string +[Term] +id: CHEBI:168396 +name: mycophenolic acid +namespace: chebi_ontology +alt_id: CHEBI:43973 +def: "A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases." [] +subset: 3_STAR +synonym: "(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid" RELATED [ChemIDplus] +synonym: "acide mycophenolique" RELATED INN [ChemIDplus] +synonym: "acido micofenolico" RELATED INN [ChemIDplus] +synonym: "acidum mycophenolicum" RELATED INN [ChemIDplus] +synonym: "Micofenolico acido" RELATED [ChemIDplus] +synonym: "Mycophenolate" RELATED [ChemIDplus] +synonym: "mycophenolic acid" RELATED INN [KEGG_DRUG] +synonym: "Mycophenolsaeure" RELATED [ChemIDplus] +xref: Beilstein:318158 {source="Beilstein"} +xref: CAS:24280-93-1 {source="DrugBank"} +xref: CAS:24280-93-1 {source="KEGG DRUG"} +xref: CAS:24280-93-1 {source="ChemIDplus"} +xref: Drug_Central:1860 {source="DrugCentral"} +xref: DrugBank:DB01024 +xref: KEGG:D05096 +xref: Patent:US4753935 +xref: PDBeChem:MOA +xref: PMID:11272311 {source="Europe PMC"} +xref: PMID:15470161 {source="Europe PMC"} +xref: PMID:16629948 {source="Europe PMC"} +xref: PMID:16640327 {source="Europe PMC"} +xref: PMID:17482154 {source="Europe PMC"} +xref: PMID:17498396 {source="Europe PMC"} +xref: PMID:18194117 {source="Europe PMC"} +xref: PMID:18611107 {source="Europe PMC"} +xref: PMID:18996104 {source="Europe PMC"} +xref: PMID:19689217 {source="Europe PMC"} +xref: Reaxys:318158 {source="Reaxys"} +xref: Wikipedia:Mycophenolic_acid +is_a: CHEBI:25384 ! monocarboxylic acid +is_a: CHEBI:33853 ! phenols +is_a: CHEBI:37581 ! gamma-lactone +is_a: CHEBI:38831 ! 2-benzofurans +relationship: has_functional_parent CHEBI:38355 ! hex-4-enoic acid +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:25442 ! mycotoxin +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:53746 ! EC 1.1.1.205 (IMP dehydrogenase) inhibitor +relationship: has_role CHEBI:76964 ! Penicillium metabolite +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_acid_of CHEBI:62932 ! mycophenolate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H20O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HPNSFSBZBAHARI-RUDMXATFSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "320.33710" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "320.12599" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O" xsd:string + [Term] id: CHEBI:16856 name: glutathione @@ -3027,6 +4935,64 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "307.320" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.08381" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O" xsd:string +[Term] +id: CHEBI:16914 +name: salicylic acid +namespace: chebi_ontology +alt_id: CHEBI:26597 +alt_id: CHEBI:45521 +alt_id: CHEBI:9006 +def: "A monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves." [] +subset: 3_STAR +synonym: "2-carboxyphenol" RELATED [NIST_Chemistry_WebBook] +synonym: "2-HYDROXYBENZOIC ACID" RELATED [PDBeChem] +synonym: "2-hydroxybenzoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "o-carboxyphenol" RELATED [NIST_Chemistry_WebBook] +synonym: "o-Hydroxybenzoic acid" RELATED [KEGG_COMPOUND] +synonym: "o-hydroxybenzoic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Salicylic acid" EXACT [KEGG_COMPOUND] +xref: Beilstein:774890 {source="Beilstein"} +xref: CAS:69-72-7 {source="ChemIDplus"} +xref: CAS:69-72-7 {source="NIST Chemistry WebBook"} +xref: CAS:69-72-7 {source="KEGG COMPOUND"} +xref: Drug_Central:2416 {source="DrugCentral"} +xref: DrugBank:DB00936 +xref: Gmelin:3418 {source="Gmelin"} +xref: HMDB:HMDB0001895 +xref: KEGG:C00805 +xref: KEGG:D00097 +xref: KNApSAcK:C00000206 +xref: LINCS:LSM-4763 +xref: MetaCyc:CPD-110 +xref: PDBeChem:SAL +xref: PMID:11016405 {source="Europe PMC"} +xref: PMID:12865403 {source="Europe PMC"} +xref: PMID:1650428 {source="Europe PMC"} +xref: PMID:19400653 {source="Europe PMC"} +xref: PMID:19816125 {source="Europe PMC"} +xref: PMID:22770225 {source="Europe PMC"} +xref: PMID:29079364 {source="Europe PMC"} +xref: PMID:32807953 {source="Europe PMC"} +xref: PMID:3425858 {source="Europe PMC"} +xref: Reaxys:774890 {source="Reaxys"} +xref: Wikipedia:Salicylic_Acid +is_a: CHEBI:25389 ! monohydroxybenzoic acid +relationship: has_role CHEBI:35441 ! antiinfective agent +relationship: has_role CHEBI:35718 ! antifungal agent +relationship: has_role CHEBI:37848 ! plant hormone +relationship: has_role CHEBI:50176 ! keratolytic drug +relationship: has_role CHEBI:73181 ! EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:84735 ! algal metabolite +relationship: is_conjugate_acid_of CHEBI:30762 ! salicylate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YGSDEFSMJLZEOE-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "138.12070" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "138.03169" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1ccccc1O" xsd:string + [Term] id: CHEBI:16919 name: creatine @@ -3113,6 +5079,71 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "131.13328" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.06948" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(CC(O)=O)C(N)=N" xsd:string +[Term] +id: CHEBI:16958 +name: beta-alanine +namespace: chebi_ontology +alt_id: CHEBI:10343 +alt_id: CHEBI:12389 +alt_id: CHEBI:22821 +alt_id: CHEBI:41050 +def: "A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position." [] +subset: 3_STAR +synonym: "3-aminopropanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "3-aminopropanoic acid" RELATED [ChEBI] +synonym: "3-Aminopropionic acid" RELATED [KEGG_COMPOUND] +synonym: "bAla" RELATED [ChEBI] +synonym: "BETA-ALANINE" EXACT [PDBeChem] +synonym: "beta-Alanine" EXACT [KEGG_COMPOUND] +synonym: "beta-alanine" EXACT IUPAC_NAME [IUPAC] +synonym: "beta-aminopropionic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "H-beta-Ala-OH" RELATED [ChEBI] +synonym: "omega-aminopropionic acid" RELATED [ChEBI] +xref: Beilstein:906793 {source="Beilstein"} +xref: CAS:107-95-9 {source="ChemIDplus"} +xref: CAS:107-95-9 {source="KEGG COMPOUND"} +xref: CAS:107-95-9 {source="NIST Chemistry WebBook"} +xref: DrugBank:DB03107 +xref: Gmelin:49614 {source="Gmelin"} +xref: HMDB:HMDB0000056 +xref: KEGG:C00099 +xref: KEGG:D07561 +xref: KNApSAcK:C00001333 +xref: MetaCyc:B-ALANINE +xref: PDBeChem:BAL +xref: PMID:11139233 {source="Europe PMC"} +xref: PMID:11850512 {source="Europe PMC"} +xref: PMID:12107759 {source="Europe PMC"} +xref: PMID:12887142 {source="Europe PMC"} +xref: PMID:14363188 {source="Europe PMC"} +xref: PMID:16934791 {source="Europe PMC"} +xref: PMID:18528519 {source="Europe PMC"} +xref: PMID:18613640 {source="Europe PMC"} +xref: PMID:19239140 {source="Europe PMC"} +xref: PMID:19955842 {source="Europe PMC"} +xref: PMID:20199122 {source="Europe PMC"} +xref: PMID:20386120 {source="Europe PMC"} +xref: PMID:20479615 {source="Europe PMC"} +xref: PMID:20994958 {source="Europe PMC"} +xref: PMID:22735334 {source="Europe PMC"} +xref: Reaxys:906793 {source="Reaxys"} +xref: Wikipedia:Beta-Alanine +is_a: CHEBI:33706 ! beta-amino acid +relationship: has_role CHEBI:25512 ! neurotransmitter +relationship: has_role CHEBI:35222 ! inhibitor +relationship: has_role CHEBI:48705 ! agonist +relationship: has_role CHEBI:77746 ! human metabolite +relationship: has_role CHEBI:78675 ! fundamental metabolite +relationship: is_conjugate_acid_of CHEBI:63070 ! beta-alaninate +relationship: is_tautomer_of CHEBI:57966 ! beta-alanine zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "89.09322" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.04768" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCC(O)=O" xsd:string + [Term] id: CHEBI:16990 name: bilirubin IXalpha @@ -3139,9 +5170,12 @@ xref: HMDB:HMDB0000054 xref: KEGG:C00486 xref: KNApSAcK:C00029828 xref: MetaCyc:BILIRUBIN +xref: PDBeChem:BLR xref: PMID:12799017 {source="Europe PMC"} xref: PMID:18442622 {source="Europe PMC"} xref: PMID:23763371 {source="Europe PMC"} +xref: PMID:23768684 {source="Europe PMC"} +xref: PMID:30224965 {source="Europe PMC"} xref: PMID:8605219 {source="Europe PMC"} xref: PMID:9587403 {source="Europe PMC"} xref: Reaxys:74376 {source="Reaxys"} @@ -3157,42 +5191,56 @@ property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H36N4O6" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BPYKTIZUTYGOLE-IFADSCNNSA-N" xsd:string -property_value: http://purl.obolibrary.org/obo/chebi/mass "584.66230" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "584.673" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "584.26348" xsd:string -property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(C=C)\\C(NC1=O)=C\\c1[nH]c(Cc2[nH]c(\\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC(O)=O)c(CCC(O)=O)c1C" xsd:string - -[Term] -id: CHEBI:16991 -name: deoxyribonucleic acid -namespace: chebi_ontology -alt_id: CHEBI:13302 -alt_id: CHEBI:21123 -alt_id: CHEBI:33698 -alt_id: CHEBI:4291 -def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." [] -subset: 3_STAR -synonym: "(Deoxyribonucleotide)m" RELATED [KEGG_COMPOUND] -synonym: "(Deoxyribonucleotide)n" RELATED [KEGG_COMPOUND] -synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG_COMPOUND] -synonym: "Deoxyribonucleic acid" EXACT [KEGG_COMPOUND] -synonym: "deoxyribonucleic acids" EXACT IUPAC_NAME [IUPAC] -synonym: "deoxyribonucleic acids" RELATED [ChEBI] -synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI] -synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus] -synonym: "DNA" RELATED [KEGG_COMPOUND] -synonym: "DNA" RELATED [IUPAC] -synonym: "DNAn" RELATED [KEGG_COMPOUND] -synonym: "DNAn+1" RELATED [KEGG_COMPOUND] -synonym: "DNS" RELATED [ChEBI] -synonym: "thymus nucleic acid" RELATED [ChEBI] -xref: CAS:9007-49-2 {source="ChemIDplus"} -xref: CAS:9007-49-2 {source="KEGG COMPOUND"} -xref: KEGG:C00039 -is_a: CHEBI:33696 ! nucleic acid -relationship: has_part CHEBI:33793 ! canonical deoxyribonucleoside residue -relationship: has_part CHEBI:50298 ! canonical deoxyribonucleotide residue -relationship: has_role CHEBI:75771 ! mouse metabolite -relationship: has_role CHEBI:77746 ! human metabolite +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(C=C)\\C(NC1=O)=C\\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\\C=C2/NC(=O)C(C=C)=C2C)N1" xsd:string + +[Term] +id: CHEBI:16998 +name: D-phenylalanine +namespace: chebi_ontology +alt_id: CHEBI:13007 +alt_id: CHEBI:21067 +alt_id: CHEBI:42207 +alt_id: CHEBI:4224 +def: "The D-enantiomer of phenylalanine." [] +subset: 3_STAR +synonym: "(2R)-2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "D-alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG_COMPOUND] +synonym: "D-Phe" RELATED [ChEBI] +synonym: "D-PHENYLALANINE" EXACT [PDBeChem] +synonym: "D-Phenylalanine" EXACT [KEGG_COMPOUND] +synonym: "D-phenylalanine" EXACT IUPAC_NAME [IUPAC] +synonym: "DPN" RELATED [PDBeChem] +synonym: "phenylalanine D-form" RELATED [ChemIDplus] +xref: Beilstein:2804068 {source="Beilstein"} +xref: CAS:673-06-3 {source="KEGG COMPOUND"} +xref: CAS:673-06-3 {source="ChemIDplus"} +xref: DrugBank:DB02556 +xref: ECMDB:ECMDB20144 +xref: Gmelin:83219 {source="Gmelin"} +xref: KEGG:C02265 +xref: MetaCyc:CPD-216 +xref: PDBeChem:DPN +xref: PMID:22382026 {source="Europe PMC"} +xref: PMID:22397264 {source="Europe PMC"} +xref: PMID:24464217 {source="Europe PMC"} +xref: PMID:7114516 {source="Europe PMC"} +xref: Reaxys:2804068 {source="Reaxys"} +xref: YMDB:YMDB00995 +is_a: CHEBI:16733 ! D-alpha-amino acid +is_a: CHEBI:28044 ! phenylalanine +relationship: is_conjugate_acid_of CHEBI:32494 ! D-phenylalaninate +relationship: is_conjugate_base_of CHEBI:32495 ! D-phenylalaninium +relationship: is_enantiomer_of CHEBI:17295 ! L-phenylalanine +relationship: is_tautomer_of CHEBI:57981 ! D-phenylalanine zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](Cc1ccccc1)C(O)=O" xsd:string [Term] id: CHEBI:17026 @@ -3292,6 +5340,7 @@ alt_id: CHEBI:5481 alt_id: CHEBI:5493 def: "A compound in which a carbohydrate component is covalently bound to a protein component." [] subset: 3_STAR +synonym: "a glycoprotein" RELATED [UniProt] synonym: "glicoproteina" RELATED [ChEBI] synonym: "glicoproteinas" RELATED [ChEBI] synonym: "Glycoprotein" EXACT [KEGG_COMPOUND] @@ -3304,6 +5353,21 @@ xref: KEGG:C00326 is_a: CHEBI:33837 ! conjugated protein is_a: CHEBI:63299 ! carbohydrate derivative +[Term] +id: CHEBI:17102 +name: phosphoramide +namespace: chebi_ontology +alt_id: CHEBI:14827 +alt_id: CHEBI:26076 +alt_id: CHEBI:8162 +def: "A compound in which one or more of the OH groups of phosphoric acid have been replaced with an amino or substituted amino group. The term is commonly confined to the phosphoric triamides, P(=O)(NR2)3, since replacement of one or two OH groups produces phosphoramidic acids: P(=O)(OH)(NR2)2 , P(=O)(OH)2(NR2)." [] +subset: 3_STAR +synonym: "phosphamide" RELATED [ChEBI] +synonym: "phosphamides" RELATED [ChEBI] +synonym: "phosphoramides" RELATED [ChEBI] +is_a: CHEBI:33256 ! primary amide +relationship: has_functional_parent CHEBI:26078 ! phosphoric acid + [Term] id: CHEBI:17126 name: carnitine @@ -3341,6 +5405,68 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "161.19894" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "161.10519" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[N+](C)(C)CC(O)CC([O-])=O" xsd:string +[Term] +id: CHEBI:17137 +name: hydrogensulfite +namespace: chebi_ontology +alt_id: CHEBI:13367 +alt_id: CHEBI:5598 +subset: 3_STAR +synonym: "[SO2(OH)](-)" RELATED [IUPAC] +synonym: "Bisulfite" RELATED [KEGG_COMPOUND] +synonym: "bisulfite" RELATED [ChemIDplus] +synonym: "bisulphite" RELATED [ChemIDplus] +synonym: "HSO3(-)" RELATED [IUPAC] +synonym: "HSO3-" RELATED [KEGG_COMPOUND] +synonym: "Hydrogen sulfite" RELATED [KEGG_COMPOUND] +synonym: "hydrogen sulfite(1-)" RELATED [ChemIDplus] +synonym: "hydrogen(trioxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrogensulfite(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrogentrioxosulfate(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrogentrioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrosulfite anion" RELATED [ChemIDplus] +synonym: "hydroxidodioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "monohydrogentrioxosulfate" EXACT IUPAC_NAME [IUPAC] +xref: CAS:15181-46-1 {source="KEGG COMPOUND"} +xref: CAS:15181-46-1 {source="ChemIDplus"} +xref: Gmelin:1455 {source="Gmelin"} +xref: KEGG:C11481 +xref: PDBeChem:SO3 +is_a: CHEBI:33482 ! sulfur oxoanion +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: is_conjugate_acid_of CHEBI:17359 ! sulfite +relationship: is_conjugate_base_of CHEBI:48854 ! sulfurous acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([O-])=O" xsd:string + +[Term] +id: CHEBI:171664 +name: antiamoebic agent +namespace: chebi_ontology +def: "An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae." [] +subset: 3_STAR +synonym: "amebicide" RELATED [ChEBI] +synonym: "amebicides" RELATED [ChEBI] +synonym: "amoebicide" RELATED [ChEBI] +synonym: "amoebicides" RELATED [ChEBI] +synonym: "anti-amoebic agent" RELATED [ChEBI] +synonym: "anti-amoebic agents" RELATED [ChEBI] +synonym: "anti-amoebic drug" RELATED [ChEBI] +synonym: "anti-amoebic drugs" RELATED [ChEBI] +synonym: "antiamoebic" RELATED [ChEBI] +synonym: "antiamoebic agents" RELATED [ChEBI] +synonym: "antiamoebic drug" RELATED [ChEBI] +synonym: "antiamoebic drugs" RELATED [ChEBI] +synonym: "antiamoebics" RELATED [ChEBI] +is_a: CHEBI:35442 ! antiparasitic agent + [Term] id: CHEBI:1722 name: 3beta-hydroxy-Delta(5)-steroid @@ -3420,6 +5546,34 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:strin property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string +[Term] +id: CHEBI:17258 +name: 7H-purine +namespace: chebi_ontology +alt_id: CHEBI:14968 +alt_id: CHEBI:8639 +def: "The 7H-tautomer of purine." [] +subset: 3_STAR +synonym: "7H-purine" EXACT IUPAC_NAME [IUPAC] +synonym: "Purine" RELATED [KEGG_COMPOUND] +synonym: "Purine base" RELATED [KEGG_COMPOUND] +xref: Beilstein:3200 {source="Beilstein"} +xref: Gmelin:601779 {source="Gmelin"} +xref: HMDB:HMDB0001366 +xref: KEGG:C15587 +xref: Reaxys:3200 {source="Reaxys"} +is_a: CHEBI:35584 ! purine +relationship: is_tautomer_of CHEBI:35586 ! 1H-purine +relationship: is_tautomer_of CHEBI:35588 ! 3H-purine +relationship: is_tautomer_of CHEBI:35589 ! 9H-purine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ncc2[nH]cnc2n1" xsd:string + [Term] id: CHEBI:17272 name: propionate @@ -3461,6 +5615,182 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "73.07060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.02950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC([O-])=O" xsd:string +[Term] +id: CHEBI:17295 +name: L-phenylalanine +namespace: chebi_ontology +alt_id: CHEBI:13151 +alt_id: CHEBI:21370 +alt_id: CHEBI:44851 +alt_id: CHEBI:44885 +alt_id: CHEBI:45079 +alt_id: CHEBI:6282 +def: "The L-enantiomer of phenylalanine." [] +subset: 3_STAR +synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-2-Amino-3-phenylpropionic acid" RELATED [HMDB] +synonym: "(S)-alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG_COMPOUND] +synonym: "3-phenyl-L-alanine" RELATED [NIST_Chemistry_WebBook] +synonym: "beta-phenyl-L-alanine" RELATED [NIST_Chemistry_WebBook] +synonym: "F" RELATED [ChEBI] +synonym: "L-Phenylalanine" EXACT [KEGG_COMPOUND] +synonym: "L-phenylalanine" EXACT IUPAC_NAME [IUPAC] +synonym: "Phe" RELATED [ChEBI] +synonym: "PHENYLALANINE" RELATED [PDBeChem] +xref: Beilstein:1910408 {source="Beilstein"} +xref: CAS:63-91-2 {source="KEGG COMPOUND"} +xref: CAS:63-91-2 {source="NIST Chemistry WebBook"} +xref: CAS:63-91-2 {source="ChemIDplus"} +xref: Drug_Central:2144 {source="DrugCentral"} +xref: DrugBank:DB00120 +xref: ECMDB:ECMDB00159 +xref: Gmelin:50837 {source="Gmelin"} +xref: HMDB:HMDB0000159 +xref: KEGG:C00079 +xref: KEGG:D00021 +xref: KNApSAcK:C00001386 +xref: MetaCyc:PHE +xref: PDBeChem:PHE +xref: PMID:13945318 {source="Europe PMC"} +xref: PMID:16893175 {source="Europe PMC"} +xref: PMID:17784858 {source="Europe PMC"} +xref: PMID:21203787 {source="Europe PMC"} +xref: PMID:21956539 {source="Europe PMC"} +xref: PMID:22081386 {source="Europe PMC"} +xref: PMID:22112574 {source="Europe PMC"} +xref: PMID:22143120 {source="Europe PMC"} +xref: PMID:22209218 {source="Europe PMC"} +xref: PMID:22494897 {source="Europe PMC"} +xref: PMID:23836015 {source="Europe PMC"} +xref: PMID:24464217 {source="Europe PMC"} +xref: PMID:24733517 {source="Europe PMC"} +xref: PMID:24966042 {source="Europe PMC"} +xref: Reaxys:1910408 {source="Reaxys"} +xref: Wikipedia:Phenylalanine +xref: YMDB:YMDB00304 +is_a: CHEBI:28044 ! phenylalanine +is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid +relationship: has_role CHEBI:27027 ! micronutrient +relationship: has_role CHEBI:50733 ! nutraceutical +relationship: has_role CHEBI:63332 ! EC 3.1.3.1 (alkaline phosphatase) inhibitor +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76967 ! human xenobiotic metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:84735 ! algal metabolite +relationship: is_conjugate_acid_of CHEBI:32486 ! L-phenylalaninate +relationship: is_conjugate_base_of CHEBI:32487 ! L-phenylalaninium +relationship: is_enantiomer_of CHEBI:16998 ! D-phenylalanine +relationship: is_tautomer_of CHEBI:58095 ! L-phenylalanine zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccccc1)C(O)=O" xsd:string + +[Term] +id: CHEBI:17303 +name: morphine +namespace: chebi_ontology +alt_id: CHEBI:14622 +alt_id: CHEBI:25419 +alt_id: CHEBI:44202 +alt_id: CHEBI:7001 +def: "A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy)." [] +subset: 3_STAR +synonym: "(-)-morphine" RELATED [ChemIDplus] +synonym: "(5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol" RELATED [ChEBI] +synonym: "(5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol" RELATED [NIST_Chemistry_WebBook] +synonym: "(5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol" RELATED [ChemIDplus] +synonym: "(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL" RELATED [PDBeChem] +synonym: "17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol" EXACT IUPAC_NAME [IUPAC] +synonym: "morfina" RELATED [ChEBI] +synonym: "Morphia" RELATED [ChemIDplus] +synonym: "Morphin" RELATED [ChemIDplus] +synonym: "Morphine" EXACT [KEGG_COMPOUND] +synonym: "morphinum" RELATED [ChemIDplus] +synonym: "morphium" RELATED [ChemIDplus] +xref: Beilstein:93704 "Beilstein" +xref: Beilstein:93704 {source="Beilstein"} +xref: CAS:57-27-2 "KEGG COMPOUND" +xref: CAS:57-27-2 {source="KEGG COMPOUND"} +xref: CAS:57-27-2 {source="NIST Chemistry WebBook"} +xref: CAS:57-27-2 {source="ChemIDplus"} +xref: Drug_Central:1845 "DrugCentral" +xref: Drug_Central:1845 {source="DrugCentral"} +xref: DrugBank:DB00295 +xref: KEGG:C01516 +xref: KEGG:D08233 +xref: KNApSAcK:C00001889 +xref: MetaCyc:MORPHINE +xref: PDB:1Q0Y +xref: PDBeChem:MOI +xref: PMID:12593758 "Europe PMC" +xref: PMID:12593758 {source="Europe PMC"} +xref: PMID:15019787 "Europe PMC" +xref: PMID:15019787 {source="Europe PMC"} +xref: PMID:17171884 "Europe PMC" +xref: PMID:17171884 {source="Europe PMC"} +xref: PMID:17667569 "Europe PMC" +xref: PMID:17667569 {source="Europe PMC"} +xref: PMID:19371311 "Europe PMC" +xref: PMID:19371311 {source="Europe PMC"} +xref: PMID:20071451 "Europe PMC" +xref: PMID:20071451 {source="Europe PMC"} +xref: PMID:21061062 {source="Europe PMC"} +xref: PMID:23292329 "Europe PMC" +xref: PMID:23292329 {source="Europe PMC"} +xref: PMID:23325235 "Europe PMC" +xref: PMID:23325235 {source="Europe PMC"} +xref: PMID:23555556 "Europe PMC" +xref: PMID:23555556 {source="Europe PMC"} +xref: PMID:23927484 "Europe PMC" +xref: PMID:23927484 {source="Europe PMC"} +xref: PMID:23988259 "Europe PMC" +xref: PMID:23988259 {source="Europe PMC"} +xref: PMID:24096538 "Europe PMC" +xref: PMID:24096538 {source="Europe PMC"} +xref: PMID:24306419 "Europe PMC" +xref: PMID:24306419 {source="Europe PMC"} +xref: PMID:27735107 "Europe PMC" +xref: PMID:27735107 {source="Europe PMC"} +xref: PMID:27815868 "Europe PMC" +xref: PMID:27815868 {source="Europe PMC"} +xref: PMID:27866460 "Europe PMC" +xref: PMID:27866460 {source="Europe PMC"} +xref: PMID:29368335 "Europe PMC" +xref: PMID:29368335 {source="Europe PMC"} +xref: PMID:9231550 "Europe PMC" +xref: PMID:9231550 {source="Europe PMC"} +xref: Reaxys:93704 {source="Reaxys"} +xref: Reaxys:93704 "Reaxys" +xref: VSDB:2982 +xref: Wikipedia:Morphine +is_a: CHEBI:25418 ! morphinane alkaloid +is_a: CHEBI:38164 ! organic heteropentacyclic compound +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_parent_hydride CHEBI:35649 ! morphinan +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35482 ! opioid analgesic +relationship: has_role CHEBI:35620 ! vasodilator agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:38867 ! anaesthetic +relationship: has_role CHEBI:55322 ! mu-opioid receptor agonist +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: has_role CHEBI:88188 ! drug allergen +relationship: is_conjugate_base_of CHEBI:58097 ! morphine(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H19NO3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BQJCRHHNABKAKU-KBQPJGBKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "285.33770" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "285.13649" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C=C[C@H](O)[C@@H]3Oc4c(O)ccc5C[C@H]1N(C)CC[C@@]23c45" xsd:string + [Term] id: CHEBI:173084 name: ferroptosis inhibitor @@ -3548,6 +5878,39 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "288.42440" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "288.20893" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]" xsd:string +[Term] +id: CHEBI:17359 +name: sulfite +namespace: chebi_ontology +alt_id: CHEBI:15139 +alt_id: CHEBI:45548 +def: "A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3)." [] +subset: 3_STAR +synonym: "[SO3](2-)" RELATED [IUPAC] +synonym: "SO3" RELATED [ChEBI] +synonym: "SO3(2-)" RELATED [IUPAC] +synonym: "sulfite" EXACT IUPAC_NAME [IUPAC] +synonym: "sulfite" EXACT [UniProt] +synonym: "SULFITE ION" RELATED [PDBeChem] +synonym: "sulphite" RELATED [ChEBI] +synonym: "trioxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC] +synonym: "trioxosulfate(2-)" EXACT IUPAC_NAME [IUPAC] +synonym: "trioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC] +xref: CAS:14265-45-3 {source="ChemIDplus"} +xref: Gmelin:1449 {source="Gmelin"} +xref: PDBeChem:SO3 +is_a: CHEBI:33482 ! sulfur oxoanion +is_a: CHEBI:48154 ! sulfur oxide +is_a: CHEBI:79388 ! divalent inorganic anion +relationship: is_conjugate_base_of CHEBI:17137 ! hydrogensulfite +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "80.06420" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95791" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])=O" xsd:string + [Term] id: CHEBI:17375 name: (2S)-2-hydroxy monocarboxylic acid @@ -3635,6 +5998,51 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "29.01800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C([*])=O" xsd:string +[Term] +id: CHEBI:17514 +name: cyanide +namespace: chebi_ontology +alt_id: CHEBI:14038 +alt_id: CHEBI:3969 +alt_id: CHEBI:41780 +def: "A pseudohalide anion that is the conjugate base of hydrogen cyanide." [] +subset: 3_STAR +synonym: "CN(-)" RELATED [IUPAC] +synonym: "CN-" RELATED [KEGG_COMPOUND] +synonym: "Cyanide" EXACT [KEGG_COMPOUND] +synonym: "Cyanide" EXACT [ChEBI] +synonym: "cyanide" EXACT IUPAC_NAME [IUPAC] +synonym: "CYANIDE ION" RELATED [PDBeChem] +synonym: "nitridocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "Prussiate" RELATED [KEGG_COMPOUND] +synonym: "Zyanid" RELATED [ChEBI] +xref: Beilstein:1900509 {source="Beilstein"} +xref: CAS:57-12-5 {source="ChemIDplus"} +xref: CAS:57-12-5 {source="NIST Chemistry WebBook"} +xref: CAS:57-12-5 {source="KEGG COMPOUND"} +xref: Gmelin:89 {source="Gmelin"} +xref: HMDB:HMDB0002084 +xref: KEGG:C00177 +xref: MetaCyc:CPD-13584 +xref: PDBeChem:CYN +xref: PMID:11386635 {source="Europe PMC"} +xref: PMID:14871577 {source="Europe PMC"} +xref: PMID:17554165 {source="Europe PMC"} +xref: PMID:7839575 {source="Europe PMC"} +xref: Reaxys:1900509 {source="Reaxys"} +xref: Wikipedia:Cyanide +is_a: CHEBI:36828 ! pseudohalide anion +relationship: has_role CHEBI:38500 ! EC 1.9.3.1 (cytochrome c oxidase) inhibitor +relationship: is_conjugate_base_of CHEBI:18407 ! hydrogen cyanide +relationship: is_conjugate_base_of CHEBI:36856 ! hydrogen isocyanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CN" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CN/c1-2/q-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XFXPMWWXUTWYJX-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "26.01740" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00362" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C-]#N" xsd:string + [Term] id: CHEBI:17522 name: alditol @@ -3779,6 +6187,78 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "121.15800" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "121.01975" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](CS)C(O)=O" xsd:string +[Term] +id: CHEBI:17568 +name: uracil +namespace: chebi_ontology +alt_id: CHEBI:15288 +alt_id: CHEBI:27210 +alt_id: CHEBI:46375 +alt_id: CHEBI:9882 +def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." [] +subset: 3_STAR +synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook] +synonym: "2,4-Dioxopyrimidine" RELATED [HMDB] +synonym: "2,4-Pyrimidinedione" RELATED [HMDB] +synonym: "pyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "U" RELATED [ChEBI] +synonym: "Ura" RELATED [CBN] +synonym: "URACIL" EXACT [PDBeChem] +synonym: "Uracil" EXACT [KEGG_COMPOUND] +synonym: "uracil" EXACT [UniProt] +synonym: "Urazil" RELATED [ChEBI] +xref: Beilstein:606623 {source="Beilstein"} +xref: CAS:66-22-8 {source="NIST Chemistry WebBook"} +xref: CAS:66-22-8 {source="KEGG COMPOUND"} +xref: CAS:66-22-8 {source="ChemIDplus"} +xref: DrugBank:DB03419 +xref: Gmelin:2896 {source="Gmelin"} +xref: HMDB:HMDB0000300 +xref: KEGG:C00106 +xref: KEGG:D00027 +xref: KNApSAcK:C00001513 +xref: MetaCyc:URACIL +xref: PDBeChem:URA +xref: PMID:11279060 {source="Europe PMC"} +xref: PMID:12855717 {source="Europe PMC"} +xref: PMID:15274295 {source="Europe PMC"} +xref: PMID:16834123 {source="Europe PMC"} +xref: PMID:17439666 {source="Europe PMC"} +xref: PMID:18533995 {source="Europe PMC"} +xref: PMID:18815805 {source="Europe PMC"} +xref: PMID:19175333 {source="Europe PMC"} +xref: PMID:22020693 {source="Europe PMC"} +xref: PMID:22074393 {source="Europe PMC"} +xref: PMID:22120518 {source="Europe PMC"} +xref: PMID:22171528 {source="Europe PMC"} +xref: PMID:22237209 {source="Europe PMC"} +xref: PMID:22299724 {source="Europe PMC"} +xref: PMID:22356544 {source="Europe PMC"} +xref: PMID:22447672 {source="Europe PMC"} +xref: PMID:22483865 {source="Europe PMC"} +xref: PMID:22567906 {source="Europe PMC"} +xref: PMID:22685418 {source="Europe PMC"} +xref: PMID:3654008 {source="Europe PMC"} +xref: Reaxys:606623 {source="Reaxys"} +xref: Wikipedia:Uracil +is_a: CHEBI:26432 ! pyrimidine nucleobase +is_a: CHEBI:38337 ! pyrimidone +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:50904 ! allergen +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: has_role CHEBI:83056 ! Daphnia magna metabolite +relationship: is_tautomer_of CHEBI:43254 ! (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ISAKRJDGNUQOIC-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "112.08684" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "112.02728" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=c1cc[nH]c(=O)[nH]1" xsd:string + [Term] id: CHEBI:17578 name: toluene @@ -3969,6 +6449,189 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "536.87264" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "536.43820" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C" xsd:string +[Term] +id: CHEBI:175901 +name: gemcitabine +namespace: chebi_ontology +alt_id: CHEBI:42752 +alt_id: CHEBI:5295 +def: "A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer." [] +subset: 3_STAR +synonym: "2',2'-Difluorodeoxycytidine" RELATED [ChemIDplus] +synonym: "2'-Deoxy-2',2'-difluorocytidine" RELATED [ChemIDplus] +synonym: "2'-deoxy-2',2'-difluorocytidine" EXACT IUPAC_NAME [IUPAC] +synonym: "4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one" RELATED [ChEMBL] +synonym: "gemcitabina" RELATED INN [DrugBank] +synonym: "gemcitabine" RELATED INN [KEGG_DRUG] +synonym: "gemcitabinum" RELATED INN [DrugBank] +xref: Beilstein:5382060 {source="Beilstein"} +xref: CAS:95058-81-4 {source="KEGG DRUG"} +xref: CAS:95058-81-4 {source="DrugBank"} +xref: CAS:95058-81-4 {source="KEGG COMPOUND"} +xref: CAS:95058-81-4 {source="ChemIDplus"} +xref: Drug_Central:1283 {source="DrugCentral"} +xref: DrugBank:DB00441 +xref: KEGG:C07650 +xref: KEGG:D02368 +xref: LINCS:LSM-5333 +xref: Patent:EP1939198 +xref: Patent:EP2108368 +xref: Patent:EP2275135 +xref: Patent:GB2136425 +xref: Patent:US2009124797 +xref: Patent:US2010111852 +xref: Patent:US4808614 +xref: PDBeChem:GEO +xref: PMID:11034044 {source="Europe PMC"} +xref: PMID:11061612 {source="Europe PMC"} +xref: PMID:11088063 {source="Europe PMC"} +xref: PMID:11122828 {source="Europe PMC"} +xref: PMID:11132538 {source="Europe PMC"} +xref: PMID:11142482 {source="Europe PMC"} +xref: PMID:11221019 {source="Europe PMC"} +xref: PMID:11356111 {source="ChEMBL"} +xref: PMID:11374818 {source="Europe PMC"} +xref: PMID:11489002 {source="Europe PMC"} +xref: PMID:11504793 {source="Europe PMC"} +xref: PMID:11510027 {source="Europe PMC"} +xref: PMID:11585734 {source="Europe PMC"} +xref: PMID:11595724 {source="Europe PMC"} +xref: PMID:11807603 {source="Europe PMC"} +xref: PMID:11859947 {source="Europe PMC"} +xref: PMID:11901308 {source="Europe PMC"} +xref: PMID:12057041 {source="Europe PMC"} +xref: PMID:12057046 {source="Europe PMC"} +xref: PMID:12057157 {source="Europe PMC"} +xref: PMID:12115355 {source="Europe PMC"} +xref: PMID:12142097 {source="Europe PMC"} +xref: PMID:12520460 {source="Europe PMC"} +xref: PMID:12571808 {source="Europe PMC"} +xref: PMID:12722678 {source="Europe PMC"} +xref: PMID:12722691 {source="Europe PMC"} +xref: PMID:12743987 {source="Europe PMC"} +xref: PMID:12761494 {source="Europe PMC"} +xref: PMID:12798170 {source="Europe PMC"} +xref: PMID:12917815 {source="Europe PMC"} +xref: PMID:12954073 {source="Europe PMC"} +xref: PMID:14606642 {source="Europe PMC"} +xref: PMID:14653877 {source="Europe PMC"} +xref: PMID:14720338 {source="Europe PMC"} +xref: PMID:15131028 {source="Europe PMC"} +xref: PMID:15160243 {source="Europe PMC"} +xref: PMID:15221904 {source="Europe PMC"} +xref: PMID:15282439 {source="Europe PMC"} +xref: PMID:15297392 {source="Europe PMC"} +xref: PMID:15542781 {source="Europe PMC"} +xref: PMID:15637766 {source="Europe PMC"} +xref: PMID:15744590 {source="Europe PMC"} +xref: PMID:16001951 {source="Europe PMC"} +xref: PMID:16041610 {source="Europe PMC"} +xref: PMID:16080557 {source="Europe PMC"} +xref: PMID:16143373 {source="Europe PMC"} +xref: PMID:16149285 {source="Europe PMC"} +xref: PMID:16317298 {source="Europe PMC"} +xref: PMID:16500746 {source="Europe PMC"} +xref: PMID:16555971 {source="Europe PMC"} +xref: PMID:16584929 {source="Europe PMC"} +xref: PMID:16807461 {source="Europe PMC"} +xref: PMID:16807463 {source="Europe PMC"} +xref: PMID:16894289 {source="Europe PMC"} +xref: PMID:16905983 {source="Europe PMC"} +xref: PMID:17101674 {source="ChEMBL"} +xref: PMID:17296311 {source="Europe PMC"} +xref: PMID:17296587 {source="Europe PMC"} +xref: PMID:17347561 {source="Europe PMC"} +xref: PMID:17429628 {source="Europe PMC"} +xref: PMID:17460420 {source="Europe PMC"} +xref: PMID:17602464 {source="ChEMBL"} +xref: PMID:17639396 {source="Europe PMC"} +xref: PMID:17887663 {source="ChEMBL"} +xref: PMID:17939651 {source="ChEMBL"} +xref: PMID:17941128 {source="Europe PMC"} +xref: PMID:17987263 {source="Europe PMC"} +xref: PMID:18035967 {source="Europe PMC"} +xref: PMID:18050344 {source="Europe PMC"} +xref: PMID:18086345 {source="Europe PMC"} +xref: PMID:18166944 {source="Europe PMC"} +xref: PMID:18186604 {source="ChEMBL"} +xref: PMID:18257544 {source="ChEMBL"} +xref: PMID:18348652 {source="Europe PMC"} +xref: PMID:18773046 {source="Europe PMC"} +xref: PMID:18789834 {source="Europe PMC"} +xref: PMID:18819792 {source="Europe PMC"} +xref: PMID:18981552 {source="Europe PMC"} +xref: PMID:19034448 {source="Europe PMC"} +xref: PMID:19177022 {source="Europe PMC"} +xref: PMID:19399788 {source="Europe PMC"} +xref: PMID:19839926 {source="Europe PMC"} +xref: PMID:19879060 {source="Europe PMC"} +xref: PMID:22763439 {source="Europe PMC"} +xref: PMID:28594276 {source="Europe PMC"} +xref: PMID:28608357 {source="Europe PMC"} +xref: PMID:28912244 {source="Europe PMC"} +xref: Reaxys:5382060 {source="Reaxys"} +xref: Wikipedia:Gemcitabine +is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside +is_a: CHEBI:37143 ! organofluorine compound +relationship: has_role CHEBI:132992 ! radiosensitizing agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:36044 ! antiviral drug +relationship: has_role CHEBI:47868 ! photosensitizing agent +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:59517 ! DNA synthesis inhibitor +relationship: has_role CHEBI:74213 ! EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11F2N3O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SDUQYLNIPVEERB-QPPQHZFASA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "263.19810" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "263.07176" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1" xsd:string + +[Term] +id: CHEBI:17608 +name: D-aldohexose +namespace: chebi_ontology +alt_id: CHEBI:12990 +alt_id: CHEBI:21038 +def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] +subset: 3_STAR +synonym: "D-aldohexoses" RELATED [ChEBI] +is_a: CHEBI:33917 ! aldohexose +is_a: CHEBI:4194 ! D-hexose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string + +[Term] +id: CHEBI:17634 +name: D-glucose +namespace: chebi_ontology +alt_id: CHEBI:12965 +alt_id: CHEBI:20999 +def: "A glucose with D-configuration." [] +subset: 3_STAR +synonym: "D(+)-glucose" RELATED [ChemIDplus] +synonym: "D-(+)-glucose" RELATED [NIST_Chemistry_WebBook] +synonym: "D-gluco-hexose" EXACT IUPAC_NAME [IUPAC] +synonym: "D-glucose" EXACT IUPAC_NAME [IUPAC] +synonym: "dextrose" RELATED [NIST_Chemistry_WebBook] +synonym: "grape sugar" RELATED [ChemIDplus] +synonym: "Traubenzucker" RELATED [ChemIDplus] +xref: CAS:50-99-7 {source="NIST Chemistry WebBook"} +xref: CAS:50-99-7 {source="ChemIDplus"} +is_a: CHEBI:17234 ! glucose +is_a: CHEBI:17608 ! D-aldohexose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string + [Term] id: CHEBI:176497 name: geroprotector @@ -4073,7 +6736,20 @@ xref: PMID:33916257 {source="Europe PMC"} xref: PMID:34064549 {source="Europe PMC"} xref: Wikipedia:Vitamin_C is_a: CHEBI:50523 ! butenolide -relationship: has_role CHEBI:27314 ! water-soluble vitamin (role) +relationship: has_role CHEBI:27314 ! water-soluble vitamin + +[Term] +id: CHEBI:176839 +name: vitamin B3 +namespace: chebi_ontology +def: "Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms)." [] +subset: 3_STAR +synonym: "vitamin B-3" RELATED [ChEBI] +synonym: "vitamin B3" EXACT [ChEBI] +synonym: "vitamin B3 vitamer" RELATED [ChEBI] +synonym: "vitamin B3 vitamers" RELATED [ChEBI] +synonym: "vitamins B3" RELATED [ChEBI] +is_a: CHEBI:75769 ! B vitamin [Term] id: CHEBI:176842 @@ -4090,6 +6766,262 @@ synonym: "vitamin B9 vitamers" RELATED [ChEBI] synonym: "vitamins B9" RELATED [ChEBI] is_a: CHEBI:75769 ! B vitamin +[Term] +id: CHEBI:17688 +name: (S)-nicotine +namespace: chebi_ontology +alt_id: CHEBI:14653 +alt_id: CHEBI:25536 +alt_id: CHEBI:44268 +alt_id: CHEBI:7562 +def: "A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum." [] +subset: 3_STAR +synonym: "(-)-3-(1-Methyl-2-pyrrolidyl)pyridine" RELATED [HMDB] +synonym: "(-)-3-(N-Methylpyrrolidino)pyridine" RELATED [HMDB] +synonym: "(-)-nicotine" RELATED [ChemIDplus] +synonym: "(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine" RELATED [HMDB] +synonym: "(S)-(-)-nicotine" RELATED [NIST_Chemistry_WebBook] +synonym: "(S)-3-(1-methylpyrrolidin-2-yl)pyridine" RELATED [KEGG_COMPOUND] +synonym: "(S)-3-(N-methylpyrrolidin-2-yl)pyridine" RELATED [IUBMB] +synonym: "(S)-Nicotine" EXACT [KEGG_COMPOUND] +synonym: "(S)-nicotine" EXACT [ChemIDplus] +synonym: "1-Methyl-2-(3-pyridyl)pyrrolidine" RELATED [HMDB] +synonym: "3-(1-Methyl-2-pyrollidinyl)pyridine" RELATED [HMDB] +synonym: "3-(1-Methylpyrrolidin-2-yl)pyridine" RELATED [HMDB] +synonym: "3-(2-(N-methylpyrrolidinyl))pyridine" RELATED [NIST_Chemistry_WebBook] +synonym: "3-(N-methylpyrollidino)pyridine" RELATED [NIST_Chemistry_WebBook] +synonym: "3-[(2S)-1-methylpyrrolidin-2-yl]pyridine" EXACT IUPAC_NAME [IUPAC] +synonym: "L(-)-nicotine" RELATED [IUBMB] +synonym: "L-3-(1-Methyl-2-pyrrolidyl)pyridine" RELATED [HMDB] +synonym: "L-Nicotine" RELATED [HMDB] +synonym: "Nicotine" RELATED [KEGG_COMPOUND] +synonym: "Nicotine" RELATED [HMDB] +xref: Beilstein:3604351 "Beilstein" +xref: Beilstein:3604351 {source="Beilstein"} +xref: Beilstein:82109 "Beilstein" +xref: Beilstein:82109 {source="Beilstein"} +xref: BPDB:485 +xref: CAS:54-11-5 "NIST Chemistry WebBook" +xref: CAS:54-11-5 {source="ChemIDplus"} +xref: CAS:54-11-5 {source="KEGG COMPOUND"} +xref: CAS:54-11-5 {source="NIST Chemistry WebBook"} +xref: Drug_Central:1920 "DrugCentral" +xref: Drug_Central:1920 {source="DrugCentral"} +xref: DrugBank:DB00184 +xref: HMDB:HMDB0001934 +xref: KEGG:C00745 +xref: KEGG:D03365 +xref: KNApSAcK:C00002057 +xref: LINCS:LSM-2093 +xref: MetaCyc:NICOTINE +xref: PDBeChem:NCT +xref: PMID:11209966 "Europe PMC" +xref: PMID:11209966 {source="Europe PMC"} +xref: PMID:11322615 "Europe PMC" +xref: PMID:11322615 {source="Europe PMC"} +xref: 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PMID:28686840 "Europe PMC" +xref: PMID:28686840 {source="Europe PMC"} +xref: PMID:28698187 "Europe PMC" +xref: PMID:28698187 {source="Europe PMC"} +xref: PMID:28700952 "Europe PMC" +xref: PMID:28700952 {source="Europe PMC"} +xref: PMID:28704277 "Europe PMC" +xref: PMID:28704277 {source="Europe PMC"} +xref: PMID:28710519 "Europe PMC" +xref: PMID:28710519 {source="Europe PMC"} +xref: PMID:28711472 "Europe PMC" +xref: PMID:28711472 {source="Europe PMC"} +xref: PMID:28714396 "Europe PMC" +xref: PMID:28714396 {source="Europe PMC"} +xref: PMID:28718768 "Europe PMC" +xref: PMID:28718768 {source="Europe PMC"} +xref: PMID:28718828 "Europe PMC" +xref: PMID:28718828 {source="Europe PMC"} +xref: PMID:28726253 "Europe PMC" +xref: PMID:28726253 {source="Europe PMC"} +xref: PMID:28735272 "Europe PMC" +xref: PMID:28735272 {source="Europe PMC"} +xref: Reaxys:82109 {source="Reaxys"} +xref: Reaxys:82109 "Reaxys" +xref: Wikipedia:Nicotine +is_a: CHEBI:138000 ! 3-(1-methylpyrrolidin-2-yl)pyridine +relationship: has_role CHEBI:22917 ! phytogenic insecticide +relationship: has_role CHEBI:35474 ! anxiolytic drug +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:47958 ! nicotinic acetylcholine receptor agonist +relationship: has_role CHEBI:49110 ! peripheral nervous system drug +relationship: has_role CHEBI:50846 ! immunomodulator +relationship: has_role CHEBI:50905 ! teratogenic agent +relationship: has_role CHEBI:50910 ! neurotoxin +relationship: has_role CHEBI:52290 ! mitogen +relationship: has_role CHEBI:59163 ! biomarker +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_base_of CHEBI:59806 ! (S)-nicotinium(1+) +relationship: is_enantiomer_of CHEBI:39162 ! (R)-nicotine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNICXCGAKADSCV-JTQLQIEISA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "162.232" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "162.11570" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C([C@]2(N(CCC2)C)[H])C=NC1" xsd:string + [Term] id: CHEBI:17716 name: lactose @@ -4328,30 +7260,53 @@ synonym: "wood alcohol" RELATED [ChemIDplus] synonym: "wood naphtha" RELATED [ChemIDplus] synonym: "wood spirit" RELATED [NIST_Chemistry_WebBook] xref: Beilstein:1098229 "Beilstein" +xref: Beilstein:1098229 {source="Beilstein"} xref: CAS:67-56-1 "NIST Chemistry WebBook" +xref: CAS:67-56-1 {source="KEGG COMPOUND"} +xref: CAS:67-56-1 {source="NIST Chemistry WebBook"} +xref: CAS:67-56-1 {source="ChemIDplus"} xref: Gmelin:449 "Gmelin" +xref: Gmelin:449 {source="Gmelin"} xref: HMDB:HMDB0001875 xref: KEGG:C00132 xref: KEGG:D02309 xref: MetaCyc:METOH xref: PDBeChem:MOH xref: PMID:11141607 "Europe PMC" +xref: PMID:11141607 {source="Europe PMC"} xref: PMID:11430978 "Europe PMC" +xref: PMID:11430978 {source="Europe PMC"} xref: PMID:11489599 "Europe PMC" +xref: PMID:11489599 {source="Europe PMC"} xref: PMID:11680737 "Europe PMC" +xref: PMID:11680737 {source="Europe PMC"} xref: PMID:11684179 "Europe PMC" +xref: PMID:11684179 {source="Europe PMC"} xref: PMID:14012711 "Europe PMC" +xref: PMID:14012711 {source="Europe PMC"} xref: PMID:14678513 "Europe PMC" +xref: PMID:14678513 {source="Europe PMC"} xref: PMID:14760634 "Europe PMC" +xref: PMID:14760634 {source="Europe PMC"} xref: PMID:15172721 "Europe PMC" +xref: PMID:15172721 {source="Europe PMC"} xref: PMID:15906011 "Europe PMC" +xref: PMID:15906011 {source="Europe PMC"} xref: PMID:16705261 "Europe PMC" +xref: PMID:16705261 {source="Europe PMC"} xref: PMID:17451998 "Europe PMC" +xref: PMID:17451998 {source="Europe PMC"} xref: PMID:17733096 "Europe PMC" +xref: PMID:17733096 {source="Europe PMC"} xref: PMID:19064074 "Europe PMC" +xref: PMID:19064074 {source="Europe PMC"} xref: PMID:19850112 "Europe PMC" +xref: PMID:19850112 {source="Europe PMC"} xref: PMID:20314698 "Europe PMC" +xref: PMID:20314698 {source="Europe PMC"} +xref: Reaxys:1098229 {source="Reaxys"} xref: Reaxys:1098229 "Reaxys" +xref: UM-BBD_compID:c0132 {source="UM-BBD"} xref: UM-BBD_compID:c0132 "UM-BBD" xref: Wikipedia:Methanol is_a: CHEBI:134179 ! volatile organic compound @@ -4413,6 +7368,108 @@ property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "RX" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "**" xsd:string +[Term] +id: CHEBI:17821 +name: thymine +namespace: chebi_ontology +alt_id: CHEBI:15247 +alt_id: CHEBI:27004 +alt_id: CHEBI:46017 +alt_id: CHEBI:9580 +def: "A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group." [] +subset: 3_STAR +synonym: "2,4-dihydroxy-5-methylpyrimidine" RELATED [NIST_Chemistry_WebBook] +synonym: "5-methyl-2,4(1H,3H)-pyrimidinedione" RELATED [NIST_Chemistry_WebBook] +synonym: "5-methylpyrimidine-2,4(1H,3H)-dione" RELATED [IUPAC] +synonym: "5-Methyluracil" RELATED [KEGG_COMPOUND] +synonym: "5-methyluracil" RELATED [NIST_Chemistry_WebBook] +synonym: "T" RELATED [ChEBI] +synonym: "Thy" RELATED [CBN] +synonym: "Thymin" RELATED [ChemIDplus] +synonym: "THYMINE" EXACT [PDBeChem] +synonym: "Thymine" EXACT [KEGG_COMPOUND] +synonym: "thymine" EXACT [UniProt] +synonym: "thymine" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:607626 {source="Beilstein"} +xref: CAS:65-71-4 {source="NIST Chemistry WebBook"} +xref: CAS:65-71-4 {source="ChemIDplus"} +xref: CAS:65-71-4 {source="KEGG COMPOUND"} +xref: DrugBank:DB03462 +xref: Gmelin:278790 {source="Gmelin"} +xref: KEGG:C00178 +xref: KNApSAcK:C00001511 +xref: PDBeChem:TDR +xref: PMID:23237383 {source="Europe PMC"} +xref: Wikipedia:Thymine +is_a: CHEBI:26432 ! pyrimidine nucleobase +is_a: CHEBI:38337 ! pyrimidone +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H6N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWQNBRDOKXIBIV-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "126.11342" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.04293" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1c[nH]c(=O)[nH]c1=O" xsd:string + +[Term] +id: CHEBI:17824 +name: propan-2-ol +namespace: chebi_ontology +alt_id: CHEBI:14897 +alt_id: CHEBI:26280 +alt_id: CHEBI:43588 +alt_id: CHEBI:8467 +def: "A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group." [] +subset: 3_STAR +synonym: "1-methylethanol" RELATED [ChemIDplus] +synonym: "1-methylethyl alcohol" RELATED [ChemIDplus] +synonym: "2-hydroxypropane" RELATED [ChemIDplus] +synonym: "2-Propanol" RELATED [KEGG_COMPOUND] +synonym: "i-propanol" RELATED [NIST_Chemistry_WebBook] +synonym: "i-Propylalkohol" RELATED [NIST_Chemistry_WebBook] +synonym: "IPA" RELATED [NIST_Chemistry_WebBook] +synonym: "Isopropanol" RELATED [KEGG_COMPOUND] +synonym: "ISOPROPYL ALCOHOL" RELATED [PDBeChem] +synonym: "Isopropyl alcohol" RELATED [KEGG_COMPOUND] +synonym: "isopropyl alcohol" RELATED [ChemIDplus] +synonym: "Isopropylalkohol" RELATED [ChEBI] +synonym: "Propan-2-ol" EXACT [KEGG_COMPOUND] +synonym: "propan-2-ol" EXACT IUPAC_NAME [IUPAC] +synonym: "propan-2-ol" EXACT [UniProt] +synonym: "sec-propanol" RELATED [NIST_Chemistry_WebBook] +xref: Beilstein:635639 {source="Beilstein"} +xref: CAS:67-63-0 {source="ChemIDplus"} +xref: CAS:67-63-0 {source="KEGG COMPOUND"} +xref: CAS:67-63-0 {source="NIST Chemistry WebBook"} +xref: Drug_Central:4215 {source="DrugCentral"} +xref: DrugBank:DB04402 +xref: Gmelin:1464 {source="Gmelin"} +xref: HMDB:HMDB0000863 +xref: KEGG:C01845 +xref: KEGG:D00137 +xref: KNApSAcK:C00048438 +xref: MetaCyc:ISO-PROPANOL +xref: PDBeChem:IPA +xref: PMID:24524727 {source="Europe PMC"} +xref: PMID:24653974 {source="Europe PMC"} +xref: Reaxys:635639 {source="Reaxys"} +xref: UM-BBD_compID:c0519 {source="UM-BBD"} +xref: Wikipedia:Isopropyl_Alcohol +xref: YMDB:YMDB01718 +is_a: CHEBI:167095 ! secondary fatty alcohol +is_a: CHEBI:35681 ! secondary alcohol +relationship: has_role CHEBI:48356 ! protic solvent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H8O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KFZMGEQAYNKOFK-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "60.09502" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.05751" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)O" xsd:string + [Term] id: CHEBI:17855 name: triglyceride @@ -4482,6 +7539,7 @@ is_a: CHEBI:138675 ! gas molecular entity is_a: CHEBI:18140 ! hydrogen halide is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:37176 ! mononuclear parent hydride +is_a: FOODON:03412972 ! food additive relationship: has_role CHEBI:75771 ! mouse metabolite relationship: is_conjugate_acid_of CHEBI:17996 ! chloride relationship: is_conjugate_base_of CHEBI:50315 ! chloronium @@ -4665,6 +7723,61 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01348" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00615" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N#N" xsd:string +[Term] +id: CHEBI:18012 +name: fumaric acid +namespace: chebi_ontology +alt_id: CHEBI:24124 +alt_id: CHEBI:42743 +alt_id: CHEBI:5190 +def: "A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle." [] +subset: 3_STAR +synonym: "(2E)-2-butenedioic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "(2E)-but-2-enedioic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(E)-2-butenedioic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "E297" RELATED [ChEBI] +synonym: "FUMARIC ACID" EXACT [PDBeChem] +synonym: "Fumaric acid" EXACT [KEGG_COMPOUND] +synonym: "Fumarsaeure" RELATED [ChEBI] +synonym: "trans-1,2-ethylenedicarboxylic acid" RELATED [ChemIDplus] +synonym: "trans-but-2-enedioic acid" RELATED [IUPAC] +synonym: "trans-Butenedioic acid" RELATED [KEGG_COMPOUND] +xref: Beilstein:605763 {source="Beilstein"} +xref: CAS:110-17-8 {source="ChemIDplus"} +xref: CAS:110-17-8 {source="NIST Chemistry WebBook"} +xref: CAS:110-17-8 {source="KEGG COMPOUND"} +xref: Drug_Central:3229 {source="DrugCentral"} +xref: DrugBank:DB01677 +xref: FooDB:FDB003291 +xref: Gmelin:49855 {source="Gmelin"} +xref: HMDB:HMDB0000134 +xref: KEGG:C00122 +xref: KEGG:D02308 +xref: KNApSAcK:C00001183 +xref: MetaCyc:FUM +xref: PDBeChem:FUM +xref: PMID:17439666 {source="Europe PMC"} +xref: PMID:21414846 {source="Europe PMC"} +xref: PMID:22113915 {source="Europe PMC"} +xref: PMID:22217732 {source="Europe PMC"} +xref: PMID:22516248 {source="Europe PMC"} +xref: PMID:23472183 {source="Europe PMC"} +xref: PPDB:1347 +xref: Reaxys:605763 {source="Reaxys"} +xref: Wikipedia:Fumaric_Acid +is_a: CHEBI:22958 ! butenedioic acid +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:64049 ! food acidity regulator +relationship: has_role CHEBI:78675 ! fundamental metabolite +relationship: is_conjugate_acid_of CHEBI:37154 ! fumarate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VZCYOOQTPOCHFL-OWOJBTEDSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "116.07220" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.01096" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)\\C=C\\C(O)=O" xsd:string + [Term] id: CHEBI:18035 name: diglyceride @@ -4693,6 +7806,40 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "89.07000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.02387" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OCC(CO[*])O[*]" xsd:string +[Term] +id: CHEBI:180482 +name: 1,2,4-triazole-3-carboxamide +namespace: chebi_ontology +def: "A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an aminocarbonyl group at position 3. It is the major catabolite and aglycon of ribavirin." [] +subset: 3_STAR +synonym: "1H-1,2,4-triazole-3-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "3-(aminocarbonyl)-1H-1,2,4-triazole" RELATED [ChEBI] +synonym: "3-carbamoyl-1H-1,2,4-triazole" RELATED [ChEBI] +xref: CAS:3641-08-5 {source="ChemIDplus"} +xref: Chemspider:58634 +xref: HMDB:HMDB0244869 +xref: PMID:1368697 {source="Europe PMC"} +xref: PMID:1368721 {source="Europe PMC"} +xref: PMID:17845853 {source="Europe PMC"} +xref: PMID:21202621 {source="Europe PMC"} +xref: PMID:212973 {source="Europe PMC"} +xref: PMID:2737800 {source="SUBMITTER"} +xref: PMID:6660848 {source="Europe PMC"} +xref: Reaxys:775120 {source="Reaxys"} +is_a: CHEBI:140324 ! primary carboxamide +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:35727 ! triazoles +is_a: CHEBI:62733 ! aromatic amide +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:84087 ! human urinary metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H4N4O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H4N4O/c4-2(8)3-5-1-6-7-3/h1H,(H2,4,8)(H,5,6,7)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZEWJFUNFEABPGL-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "112.092" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "112.03851" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)C1=NNC=N1" xsd:string + [Term] id: CHEBI:18059 name: lipid @@ -4945,6 +8092,7 @@ def: "An iron group element atom that has atomic number 26." [] subset: 3_STAR synonym: "26Fe" RELATED [IUPAC] synonym: "Eisen" RELATED [ChEBI] +synonym: "Fe" RELATED [UniProt] synonym: "Fe" RELATED [IUPAC] synonym: "fer" RELATED [ChEBI] synonym: "ferrum" RELATED [IUPAC] @@ -5033,6 +8181,33 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "650.97350" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "650.79004" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O" xsd:string +[Term] +id: CHEBI:18274 +name: 2'-deoxyribonucleoside +namespace: chebi_ontology +alt_id: CHEBI:1083 +alt_id: CHEBI:11394 +alt_id: CHEBI:11567 +alt_id: CHEBI:11568 +alt_id: CHEBI:19259 +alt_id: CHEBI:19560 +alt_id: CHEBI:4421 +subset: 3_STAR +synonym: "2'-Deoxynucleoside" RELATED [KEGG_COMPOUND] +synonym: "2'-deoxyribonucleosides" RELATED [ChEBI] +synonym: "2-Deoxy-D-ribosyl-base" RELATED [KEGG_COMPOUND] +synonym: "a 2'-deoxyribonucleoside" RELATED [UniProt] +synonym: "Deoxynucleoside" RELATED [KEGG_COMPOUND] +xref: KEGG:C02269 +xref: KEGG:C03216 +is_a: CHEBI:23636 ! deoxyribonucleoside +is_a: CHEBI:47018 ! monohydroxytetrahydrofuran +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O3R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "117.123" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "117.05517" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@@H]([*])C[C@@H]1O" xsd:string + [Term] id: CHEBI:18282 name: nucleobase @@ -5098,6 +8273,34 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "116.07216" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.01096" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)\\C=C/C(O)=O" xsd:string +[Term] +id: CHEBI:18310 +name: alkane +namespace: chebi_ontology +alt_id: CHEBI:13435 +alt_id: CHEBI:22317 +alt_id: CHEBI:2576 +def: "An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms." [] +subset: 3_STAR +synonym: "alcane" RELATED [IUPAC] +synonym: "alcanes" RELATED [IUPAC] +synonym: "alcano" RELATED [IUPAC] +synonym: "alcanos" RELATED [IUPAC] +synonym: "Alkan" RELATED [ChEBI] +synonym: "Alkane" EXACT [KEGG_COMPOUND] +synonym: "alkane" EXACT IUPAC_NAME [IUPAC] +synonym: "alkanes" EXACT IUPAC_NAME [IUPAC] +synonym: "an alkane" RELATED [UniProt] +synonym: "RH" RELATED [KEGG_COMPOUND] +xref: KEGG:C01371 +is_a: CHEBI:24632 ! hydrocarbon +is_a: CHEBI:33653 ! aliphatic compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "15.035" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.02348" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[*]" xsd:string + [Term] id: CHEBI:18357 name: (R)-noradrenaline @@ -5191,6 +8394,369 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "94.97136" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.95507" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])([O-])=O" xsd:string +[Term] +id: CHEBI:18379 +name: nitrile +namespace: chebi_ontology +alt_id: CHEBI:13212 +alt_id: CHEBI:13426 +alt_id: CHEBI:13660 +alt_id: CHEBI:25547 +alt_id: CHEBI:7584 +def: "A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it." [] +subset: 3_STAR +synonym: "a nitrile" RELATED [UniProt] +synonym: "Nitril" RELATED [ChEBI] +synonym: "Nitrile" EXACT [KEGG_COMPOUND] +synonym: "nitrile" EXACT [IUPAC] +synonym: "nitriles" EXACT IUPAC_NAME [IUPAC] +synonym: "nitrilos" RELATED [IUPAC] +synonym: "R-CN" RELATED [KEGG_COMPOUND] +xref: KEGG:C00726 +is_a: CHEBI:23424 ! cyanides +relationship: has_part CHEBI:48819 ! cyano group +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CNR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "26.01740" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00307" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C#N" xsd:string + +[Term] +id: CHEBI:18401 +name: phenylacetate +namespace: chebi_ontology +alt_id: CHEBI:14779 +alt_id: CHEBI:25975 +def: "A monocarboxylic acid anion that is the conjugate base of phenylacetic acid." [] +subset: 3_STAR +synonym: "2-phenylacetate" RELATED [UniProt] +synonym: "2-phenylethanoate" RELATED [ChEBI] +synonym: "phenylacetate" EXACT IUPAC_NAME [IUPAC] +synonym: "phenylacetate anion" RELATED [ChEBI] +synonym: "phenylacetate(1-)" RELATED [ChEBI] +synonym: "phenylacetic acid anion" RELATED [ChEBI] +xref: Beilstein:3539899 {source="Beilstein"} +xref: Gmelin:327522 {source="Gmelin"} +xref: MetaCyc:PHENYLACETATE +xref: Reaxys:3539899 {source="Reaxys"} +xref: UM-BBD_compID:c0211 {source="UM-BBD"} +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: has_functional_parent CHEBI:30089 ! acetate +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: is_conjugate_base_of CHEBI:30745 ! phenylacetic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H7O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLJVXDMOQOGPHL-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "135.13998" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.04515" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)Cc1ccccc1" xsd:string + +[Term] +id: CHEBI:18407 +name: hydrogen cyanide +namespace: chebi_ontology +alt_id: CHEBI:13362 +alt_id: CHEBI:5786 +def: "A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom" [] +subset: 3_STAR +synonym: "[CHN]" RELATED [IUPAC] +synonym: "Blausaeure" RELATED [ChEBI] +synonym: "Cyanwasserstoff" RELATED [NIST_Chemistry_WebBook] +synonym: "formonitrile" RELATED [IUPAC] +synonym: "HCN" RELATED [KEGG_COMPOUND] +synonym: "hydridonitridocarbon" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrocyanic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Hydrogen cyanide" EXACT [KEGG_COMPOUND] +synonym: "hydrogen cyanide" EXACT [IUPAC] +synonym: "hydrogen cyanide" EXACT [UniProt] +synonym: "hydrogen(nitridocarbonate)" EXACT IUPAC_NAME [IUPAC] +synonym: "methanenitrile" EXACT IUPAC_NAME [IUPAC] +xref: CAS:74-90-8 {source="ChemIDplus"} +xref: CAS:74-90-8 {source="NIST Chemistry WebBook"} +xref: CAS:74-90-8 {source="KEGG COMPOUND"} +xref: HMDB:HMDB0060292 +xref: KEGG:C01326 +xref: KNApSAcK:C00007569 +xref: MetaCyc:HCN +xref: PMID:19849830 {source="Europe PMC"} +xref: PMID:26700190 {source="Europe PMC"} +xref: PMID:26778429 {source="Europe PMC"} +xref: PMID:26823582 {source="Europe PMC"} +xref: PMID:26940198 {source="Europe PMC"} +xref: PMID:27123778 {source="Europe PMC"} +xref: Reaxys:1718793 {source="Reaxys"} +xref: Wikipedia:Hydrogen_cyanide +is_a: CHEBI:33405 ! hydracid +is_a: CHEBI:64708 ! one-carbon compound +relationship: has_role CHEBI:64909 ! poison +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide +relationship: is_tautomer_of CHEBI:36856 ! hydrogen isocyanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CHN/c1-2/h1H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LELOWRISYMNNSU-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "27.02530" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.01090" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C#N" xsd:string + +[Term] +id: CHEBI:18723 +name: nicotine +namespace: chebi_ontology +def: "A racemate composed of equimolar amounts of (R)- and (S)-nicotine." [] +subset: 3_STAR +synonym: "(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine" RELATED [KEGG_COMPOUND] +synonym: "(+-)-nicotine" RELATED [ChemIDplus] +synonym: "(R,S)-nicotine" RELATED [ChemIDplus] +synonym: "(RS)-nicotine" RELATED [UM-BBD] +synonym: "nicotin" RELATED [ChEBI] +synonym: "nikotin" RELATED [ChEBI] +synonym: "rac-3-(1-methylpyrrolidin-2-yl)pyridine" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:82108 "Beilstein" +xref: Beilstein:82108 {source="Beilstein"} +xref: Beilstein:82111 "Beilstein" +xref: Beilstein:82111 {source="Beilstein"} +xref: CAS:22083-74-5 "ChemIDplus" +xref: CAS:22083-74-5 {source="ChemIDplus"} +xref: CAS:22083-74-5 {source="KEGG COMPOUND"} +xref: DrugBank:DB00184 +xref: HMDB:HMDB0014330 +xref: KEGG:C16150 +xref: KNApSAcK:C00002057 +xref: PMID:10751565 "Europe PMC" +xref: PMID:10751565 {source="Europe PMC"} +xref: PMID:11192937 "Europe PMC" +xref: PMID:11192937 {source="Europe PMC"} +xref: PMID:11471991 "Europe PMC" +xref: PMID:11471991 {source="Europe PMC"} +xref: PMID:11559179 "Europe PMC" +xref: PMID:11559179 {source="Europe PMC"} +xref: PMID:11682702 "Europe PMC" +xref: PMID:11682702 {source="Europe PMC"} +xref: PMID:11714820 "Europe PMC" +xref: PMID:11714820 {source="Europe PMC"} +xref: PMID:11719700 "Europe PMC" +xref: PMID:11719700 {source="Europe PMC"} +xref: PMID:11801622 "Europe PMC" +xref: PMID:11801622 {source="Europe PMC"} +xref: PMID:11818389 "Europe PMC" +xref: PMID:11818389 {source="Europe PMC"} +xref: PMID:11860617 "Europe PMC" +xref: PMID:11860617 {source="Europe PMC"} +xref: PMID:12197757 "Europe PMC" +xref: PMID:12197757 {source="Europe PMC"} +xref: PMID:12700710 "Europe PMC" +xref: PMID:12700710 {source="Europe PMC"} +xref: PMID:12965231 "Europe PMC" +xref: PMID:12965231 {source="Europe PMC"} +xref: PMID:14715938 "Europe PMC" +xref: PMID:14715938 {source="Europe PMC"} +xref: PMID:15183514 "Europe PMC" +xref: PMID:15183514 {source="Europe PMC"} +xref: PMID:15251917 "Europe PMC" +xref: PMID:15251917 {source="Europe PMC"} +xref: PMID:15313135 "Europe PMC" +xref: PMID:15313135 {source="Europe PMC"} +xref: PMID:15458549 "Europe PMC" +xref: PMID:15458549 {source="Europe PMC"} +xref: PMID:15707677 "Europe PMC" +xref: PMID:15707677 {source="Europe PMC"} +xref: PMID:15894687 "Europe PMC" +xref: PMID:15894687 {source="Europe PMC"} +xref: PMID:15960296 "Europe PMC" +xref: PMID:15960296 {source="Europe PMC"} +xref: PMID:15961264 "Europe PMC" +xref: PMID:15961264 {source="Europe PMC"} +xref: PMID:16496293 "Europe PMC" +xref: PMID:16496293 {source="Europe PMC"} +xref: PMID:16950410 "Europe PMC" +xref: PMID:16950410 {source="Europe PMC"} +xref: PMID:17167832 "Europe PMC" +xref: PMID:17167832 {source="Europe PMC"} +xref: PMID:17206646 "Europe PMC" +xref: PMID:17206646 {source="Europe PMC"} +xref: PMID:17438652 "Europe PMC" +xref: PMID:17438652 {source="Europe PMC"} +xref: PMID:17498149 "Europe PMC" +xref: PMID:17498149 {source="Europe PMC"} +xref: PMID:17942810 "Europe PMC" +xref: PMID:17942810 {source="Europe PMC"} +xref: PMID:18077004 "Europe PMC" +xref: PMID:18077004 {source="Europe PMC"} +xref: PMID:18311975 "Europe PMC" +xref: PMID:18311975 {source="Europe PMC"} +xref: PMID:18380035 "Europe PMC" +xref: PMID:18380035 {source="Europe PMC"} +xref: PMID:18383130 "Europe PMC" +xref: PMID:18383130 {source="Europe PMC"} +xref: PMID:18651995 "Europe PMC" +xref: PMID:18651995 {source="Europe PMC"} +xref: PMID:18922921 "Europe PMC" +xref: PMID:18922921 {source="Europe PMC"} +xref: PMID:19100331 "Europe PMC" +xref: PMID:19100331 {source="Europe PMC"} +xref: PMID:19287496 "Europe PMC" +xref: PMID:19287496 {source="Europe PMC"} +xref: PMID:19389046 "Europe PMC" +xref: PMID:19389046 {source="Europe PMC"} +xref: PMID:19465085 "Europe PMC" +xref: PMID:19465085 {source="Europe PMC"} +xref: PMID:20338106 "Europe PMC" +xref: PMID:20338106 {source="Europe PMC"} +xref: PMID:20528766 "Europe PMC" +xref: PMID:20528766 {source="Europe PMC"} +xref: PMID:21636612 "Europe PMC" +xref: PMID:21636612 {source="Europe PMC"} +xref: PMID:21822688 "Europe PMC" +xref: PMID:21822688 {source="Europe PMC"} +xref: PMID:21945235 "Europe PMC" +xref: PMID:21945235 {source="Europe PMC"} +xref: PMID:22129149 "Europe PMC" +xref: PMID:22129149 {source="Europe PMC"} +xref: PMID:22218403 "Europe PMC" +xref: PMID:22218403 {source="Europe PMC"} +xref: PMID:22331007 "Europe PMC" +xref: PMID:22331007 {source="Europe PMC"} +xref: PMID:22377934 "Europe PMC" +xref: PMID:22377934 {source="Europe PMC"} +xref: PMID:22448647 "Europe PMC" +xref: PMID:22448647 {source="Europe PMC"} +xref: PMID:22459798 "Europe PMC" +xref: PMID:22459798 {source="Europe PMC"} +xref: PMID:22529223 "Europe PMC" +xref: PMID:22529223 {source="Europe PMC"} +xref: PMID:22573728 "Europe PMC" +xref: PMID:22573728 {source="Europe PMC"} +xref: PMID:22585541 "Europe PMC" +xref: PMID:22585541 {source="Europe PMC"} +xref: PMID:22589423 "Europe PMC" +xref: PMID:22589423 {source="Europe PMC"} +xref: PMID:22770225 "Europe PMC" +xref: PMID:22770225 {source="Europe PMC"} +xref: PMID:22792725 "Europe PMC" +xref: PMID:22792725 {source="Europe PMC"} +xref: PMID:22855884 "Europe PMC" +xref: PMID:22855884 {source="Europe PMC"} +xref: PMID:22930863 "Europe PMC" +xref: PMID:22930863 {source="Europe PMC"} +xref: PMID:22935730 "Europe PMC" +xref: PMID:22935730 {source="Europe PMC"} +xref: PMID:23108361 "Europe PMC" +xref: PMID:23108361 {source="Europe PMC"} +xref: PMID:23117126 "Europe PMC" +xref: PMID:23117126 {source="Europe PMC"} +xref: PMID:7097594 "Europe PMC" +xref: PMID:7097594 {source="Europe PMC"} +xref: PMID:7564279 "Europe PMC" +xref: PMID:7564279 {source="Europe PMC"} +xref: PMID:7566693 "Europe PMC" +xref: PMID:7566693 {source="Europe PMC"} +xref: PMID:7807214 "Europe PMC" +xref: PMID:7807214 {source="Europe PMC"} +xref: PMID:7896575 "Europe PMC" +xref: PMID:7896575 {source="Europe PMC"} +xref: PMID:8156919 "Europe PMC" +xref: PMID:8156919 {source="Europe PMC"} +xref: PMID:8545712 "Europe PMC" +xref: PMID:8545712 {source="Europe PMC"} +xref: PMID:8764340 "Europe PMC" +xref: PMID:8764340 {source="Europe PMC"} +xref: PMID:9203638 "Europe PMC" +xref: PMID:9203638 {source="Europe PMC"} +xref: PMID:9450943 "Europe PMC" +xref: PMID:9450943 {source="Europe PMC"} +xref: PMID:9621392 "Europe PMC" +xref: PMID:9621392 {source="Europe PMC"} +xref: Reaxys:82108 {source="Reaxys"} +xref: Reaxys:82108 "Reaxys" +xref: UM-BBD_compID:c0468 {source="UM-BBD"} +xref: UM-BBD_compID:c0468 "UM-BBD" +xref: Wikipedia:Nicotine +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:17688 ! (S)-nicotine +relationship: has_part CHEBI:39162 ! (R)-nicotine +relationship: has_role CHEBI:35474 ! anxiolytic drug +relationship: has_role CHEBI:47958 ! nicotinic acetylcholine receptor agonist +relationship: has_role CHEBI:49110 ! peripheral nervous system drug +relationship: has_role CHEBI:50846 ! immunomodulator +relationship: has_role CHEBI:50905 ! teratogenic agent +relationship: has_role CHEBI:50910 ! neurotoxin +relationship: has_role CHEBI:52290 ! mitogen +relationship: has_role CHEBI:59163 ! biomarker + +[Term] +id: CHEBI:18946 +name: delta-lactone +namespace: chebi_ontology +def: "A lactone having a six-membered lactone ring." [] +subset: 3_STAR +synonym: "1,5-lactone" RELATED [ChEBI] +synonym: "1,5-lactones" RELATED [ChEBI] +synonym: "delta-lactona" RELATED [ChEBI] +synonym: "delta-lactonas" RELATED [ChEBI] +synonym: "delta-lactone" EXACT [ChEBI] +synonym: "delta-lactones" RELATED [ChEBI] +is_a: CHEBI:25000 ! lactone + +[Term] +id: CHEBI:19255 +name: pyrimidine 2'-deoxyribonucleoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "pyrimidine 2'-deoxyribonucleosides" RELATED [ChEBI] +is_a: CHEBI:18274 ! 2'-deoxyribonucleoside +is_a: CHEBI:68472 ! pyrimidine deoxyribonucleoside + +[Term] +id: CHEBI:20156 +name: 3-oxo-Delta(1) steroid +namespace: chebi_ontology +alt_id: CHEBI:13603 +alt_id: CHEBI:1625 +def: "Any 3-oxo steroid that contains a double bond between positions 1 and 2." [] +subset: 3_STAR +synonym: "3-keto-Delta(1) steroid" RELATED [ChEBI] +synonym: "3-keto-Delta(1) steroids" RELATED [ChEBI] +synonym: "3-oxo Delta(1)-steroid" RELATED [ChEBI] +synonym: "3-oxo Delta(1)-steroids" RELATED [ChEBI] +synonym: "3-oxo-Delta(1) steroid" EXACT [ChEBI] +synonym: "3-oxo-Delta(1) steroids" RELATED [ChEBI] +synonym: "3-oxo-Delta(1)-steroids" RELATED [ChEBI] +synonym: "3-oxo-Delta1-steroid" RELATED [ChEBI] +synonym: "3-oxo-Delta1-steroids" RELATED [ChEBI] +synonym: "a 3-oxo-Delta(1)-steroid" RELATED [UniProt] +xref: KEGG:C02941 +xref: MetaCyc:3-Oxo-Delta-1-Steroids +is_a: CHEBI:47788 ! 3-oxo steroid +is_a: CHEBI:51689 ! enone +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H27OR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "271.418" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "271.20619" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(C=CC(C4)=O)C" xsd:string + +[Term] +id: CHEBI:20664 +name: 5beta-cholane +namespace: chebi_ontology +subset: 3_STAR +synonym: "5beta-cholane" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:2048472 {source="Beilstein"} +is_a: CHEBI:35519 ! cholane +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H42" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18+,19+,20-,21+,22+,23+,24-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QSHQKIURKJITMZ-OBUPQJQESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "330.59028" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.32865" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC" xsd:string + [Term] id: CHEBI:21644 name: N-acyl-L-amino acid @@ -5200,6 +8766,63 @@ subset: 3_STAR is_a: CHEBI:51569 ! N-acyl-amino acid relationship: is_enantiomer_of CHEBI:15778 ! N-acyl-D-amino acid +[Term] +id: CHEBI:21731 +name: N-glycosyl compound +namespace: chebi_ontology +def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." [] +subset: 3_STAR +synonym: "glycosylamine" EXACT IUPAC_NAME [IUPAC] +synonym: "glycosylamines" RELATED [IUPAC] +synonym: "N-glycoside" RELATED [ChEBI] +synonym: "N-glycosides" RELATED [ChEBI] +synonym: "N-glycosyl compounds" RELATED [ChEBI] +is_a: CHEBI:35352 ! organonitrogen compound +is_a: CHEBI:63161 ! glycosyl compound + +[Term] +id: CHEBI:2208 +name: purine-6-thiol +namespace: chebi_ontology +def: "A thiol that is the tautomer of mercaptopurine." [] +subset: 3_STAR +synonym: "1,7-Dihydro-6H-purine-6-thione" RELATED [ChemIDplus] +synonym: "3H-Purine-6-thiol" RELATED [ChemIDplus] +synonym: "6-MP" RELATED [ChemIDplus] +synonym: "6-Thiohypoxanthine" RELATED [ChemIDplus] +synonym: "7H-purine-6-thiol" EXACT IUPAC_NAME [IUPAC] +xref: CAS:50-44-2 {source="KEGG COMPOUND"} +xref: CAS:50-44-2 {source="ChemIDplus"} +xref: DrugBank:DB01033 +xref: KEGG:C01756 +xref: KEGG:C02380 +xref: PDBeChem:PM6 +xref: PMID:24211998 {source="Europe PMC"} +xref: PMID:24651962 {source="Europe PMC"} +xref: PMID:24670805 {source="Europe PMC"} +xref: PMID:24774509 {source="Europe PMC"} +xref: Reaxys:608595 {source="Reaxys"} +is_a: CHEBI:82711 ! aryl thiol +relationship: has_parent_hydride CHEBI:17258 ! 7H-purine +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: is_tautomer_of CHEBI:50667 ! mercaptopurine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GLVAUDGFNGKCSF-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "152.17822" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "152.01567" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Sc1ncnc2nc[nH]c12" xsd:string + +[Term] +id: CHEBI:22160 +name: acetamides +namespace: chebi_ontology +def: "Compounds with the general formula RNHC(=O)CH3." [] +subset: 3_STAR +is_a: CHEBI:37622 ! carboxamide + [Term] id: CHEBI:22221 name: acyl group @@ -5264,6 +8887,32 @@ xref: Wikipedia:Alkaloid is_a: CHEBI:35352 ! organonitrogen compound relationship: has_role CHEBI:25212 ! metabolite +[Term] +id: CHEBI:22327 +name: aliphatic sulfide +namespace: chebi_ontology +subset: 3_STAR +synonym: "aliphatic thioether" RELATED [ChEBI] +synonym: "aliphatic thioethers" RELATED [ChEBI] +is_a: CHEBI:16385 ! organic sulfide + +[Term] +id: CHEBI:22333 +name: alkylating agent +namespace: chebi_ontology +def: "Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases." [] +subset: 3_STAR +is_a: CHEBI:25435 ! mutagen + +[Term] +id: CHEBI:22475 +name: amino acid amide +namespace: chebi_ontology +def: "An amide of an amino acid formed formally by conversion of the carboxy group to a carboxamido group." [] +subset: 3_STAR +is_a: CHEBI:37622 ! carboxamide +is_a: CHEBI:83821 ! amino acid derivative + [Term] id: CHEBI:22478 name: amino alcohol @@ -5321,6 +8970,24 @@ synonym: "aminoglycans" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:65212 ! polysaccharide derivative +[Term] +id: CHEBI:22527 +name: aminopurine +namespace: chebi_ontology +def: "Any purine having at least one amino substituent." [] +subset: 3_STAR +synonym: "aminopurines" RELATED [ChEBI] +is_a: CHEBI:26401 ! purines + +[Term] +id: CHEBI:22562 +name: anilines +namespace: chebi_ontology +def: "Any aromatic amine that is benzene carrying at least one amino substituent and its substituted derivatives." [] +subset: 3_STAR +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:33860 ! aromatic amine + [Term] id: CHEBI:22563 name: anion @@ -5335,6 +9002,17 @@ synonym: "aniones" RELATED [ChEBI] synonym: "anions" RELATED [IUPAC] is_a: CHEBI:24870 ! ion +[Term] +id: CHEBI:22565 +name: ansamycin +namespace: chebi_ontology +def: "A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain." [] +subset: 3_STAR +xref: Wikipedia:Ansamycin +is_a: CHEBI:24995 ! lactam +is_a: CHEBI:26188 ! polyketide +is_a: CHEBI:51026 ! macrocycle + [Term] id: CHEBI:22586 name: antioxidant @@ -5346,6 +9024,38 @@ synonym: "antioxydant" RELATED [ChEBI] synonym: "antoxidant" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role +[Term] +id: CHEBI:22587 +name: antiviral agent +namespace: chebi_ontology +def: "A substance that destroys or inhibits replication of viruses." [] +subset: 3_STAR +synonym: "anti-viral agent" RELATED [ChEBI] +synonym: "anti-viral agents" RELATED [ChEBI] +synonym: "antiviral" RELATED [ChEBI] +synonym: "antiviral agents" RELATED [ChEBI] +synonym: "antivirals" RELATED [ChEBI] +is_a: CHEBI:33281 ! antimicrobial agent + +[Term] +id: CHEBI:22601 +name: arabinoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "arabinoside" EXACT [ChEBI] +synonym: "arabinosides" RELATED [ChEBI] +is_a: CHEBI:35312 ! pentoside + +[Term] +id: CHEBI:22645 +name: arenecarboxamide +namespace: chebi_ontology +def: "A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system." [] +subset: 3_STAR +synonym: "arenecarboxamides" RELATED [ChEBI] +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:62733 ! aromatic amide + [Term] id: CHEBI:22651 name: ascorbate @@ -5364,6 +9074,26 @@ subset: 3_STAR is_a: CHEBI:24963 ! ketoaldonic acid relationship: is_conjugate_acid_of CHEBI:22651 ! ascorbate +[Term] +id: CHEBI:22676 +name: auxin +namespace: chebi_ontology +def: "Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, \"to grow\")." [] +subset: 3_STAR +synonym: "auxins" RELATED [ChEBI] +xref: Wikipedia:Auxin +is_a: CHEBI:37848 ! plant hormone + +[Term] +id: CHEBI:22682 +name: azobenzenes +namespace: chebi_ontology +def: "Any member of the wide class of molecules that share the core azobenzene structure, comprising two phenyl rings linked by a N=N double bond, which may have different functional groups extending from the rings." [] +subset: 3_STAR +synonym: "azobenzenes" EXACT [ChEBI] +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:37533 ! azo compound + [Term] id: CHEBI:22695 name: base @@ -5381,6 +9111,13 @@ synonym: "Nucleobase" RELATED [KEGG_COMPOUND] xref: KEGG:C00701 is_a: CHEBI:51086 ! chemical role +[Term] +id: CHEBI:22702 +name: benzamides +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:22645 ! arenecarboxamide + [Term] id: CHEBI:22712 name: benzenes @@ -5389,6 +9126,15 @@ def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its subset: 3_STAR is_a: CHEBI:33836 ! benzenoid aromatic compound +[Term] +id: CHEBI:22715 +name: benzimidazoles +namespace: chebi_ontology +def: "An organic heterocyclic compound containing a benzene ring fused to an imidazole ring." [] +subset: 3_STAR +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + [Term] id: CHEBI:22718 name: benzoates @@ -5397,6 +9143,18 @@ def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group subset: 3_STAR synonym: "benzoate anion" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion +is_a: CHEBI:91007 ! aromatic carboxylate + +[Term] +id: CHEBI:22720 +name: benzodiazepine +namespace: chebi_ontology +def: "A group of heterocyclic compounds with a core structure containing a benzene ring fused to a diazepine ring." [] +subset: 3_STAR +synonym: "benzodiazepines" RELATED [ChEBI] +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38166 ! organic heteropolycyclic compound +relationship: has_role CHEBI:50268 ! GABA modulator [Term] id: CHEBI:22723 @@ -5407,6 +9165,14 @@ subset: 3_STAR is_a: CHEBI:22712 ! benzenes is_a: CHEBI:33859 ! aromatic carboxylic acid +[Term] +id: CHEBI:22726 +name: benzophenones +namespace: chebi_ontology +def: "Any aromatic ketone in which the carbonyl group is bonded to 2 phenyl groups." [] +subset: 3_STAR +is_a: CHEBI:76224 ! aromatic ketone + [Term] id: CHEBI:22727 name: benzopyran @@ -5446,6 +9212,34 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "91.13048" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "91.05478" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C=CC=C1)C*" xsd:string +[Term] +id: CHEBI:22798 +name: beta-D-glucoside +namespace: chebi_ontology +alt_id: CHEBI:10400 +def: "Any D-glucoside in which the anomeric centre has beta-configuration." [] +subset: 3_STAR +synonym: "a beta-D-glucoside" RELATED [UniProt] +synonym: "beta-D-glucoside" EXACT [ChEBI] +synonym: "beta-D-glucosides" RELATED [ChEBI] +xref: KEGG:C00963 +is_a: CHEBI:35436 ! D-glucoside +is_a: CHEBI:60980 ! beta-glucoside +relationship: has_functional_parent CHEBI:15903 ! beta-D-glucose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H11O6R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "179.148" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.05556" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1(O[C@H]([C@H](O)[C@H]([C@@H]1O)O)O*)CO" xsd:string + +[Term] +id: CHEBI:22823 +name: beta-alanine derivative +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:83812 ! non-proteinogenic amino acid derivative +relationship: has_functional_parent CHEBI:16958 ! beta-alanine + [Term] id: CHEBI:22860 name: amino-acid betaine @@ -5478,6 +9272,50 @@ subset: 3_STAR xref: MetaCyc:All-Biopterines is_a: CHEBI:26375 ! pterins +[Term] +id: CHEBI:22888 +name: biphenyls +namespace: chebi_ontology +def: "Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond." [] +subset: 3_STAR +is_a: CHEBI:33836 ! benzenoid aromatic compound +is_a: CHEBI:36820 ! ring assembly +is_a: CHEBI:64459 ! biaryl + +[Term] +id: CHEBI:22907 +name: bleomycin +namespace: chebi_ontology +alt_id: CHEBI:584977 +def: "A glycopeptide produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2." [] +subset: 3_STAR +xref: DrugBank:DB00290 +xref: Wikipedia:Bleomycin +is_a: CHEBI:23089 ! chelate-forming peptide +is_a: CHEBI:24396 ! glycopeptide + +[Term] +id: CHEBI:22916 +name: boron molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "boron compounds" RELATED [ChEBI] +synonym: "boron molecular entities" RELATED [ChEBI] +synonym: "boron molecular entity" EXACT [ChEBI] +is_a: CHEBI:33581 ! boron group molecular entity +relationship: has_part CHEBI:27560 ! boron atom + +[Term] +id: CHEBI:22917 +name: phytogenic insecticide +namespace: chebi_ontology +def: "An insecticide compound naturally occurring in plants." [] +subset: 3_STAR +synonym: "botanical insecticide" RELATED [ChEBI] +synonym: "botanical insecticides" RELATED [ChEBI] +synonym: "phytogenic insecticides" RELATED [ChEBI] +is_a: CHEBI:24852 ! insecticide + [Term] id: CHEBI:22958 name: butenedioic acid @@ -5503,6 +9341,7 @@ namespace: chebi_ontology subset: 3_STAR synonym: "20Ca" RELATED [IUPAC] synonym: "Ca" RELATED [IUPAC] +synonym: "Ca" RELATED [UniProt] synonym: "calcio" RELATED [ChEBI] synonym: "Calcium" RELATED [KEGG_COMPOUND] synonym: "calcium" EXACT IUPAC_NAME [IUPAC] @@ -5533,6 +9372,18 @@ synonym: "calcium molecular entity" EXACT [ChEBI] is_a: CHEBI:33299 ! alkaline earth molecular entity relationship: has_part CHEBI:22984 ! calcium atom +[Term] +id: CHEBI:23003 +name: carbamate ester +namespace: chebi_ontology +def: "Any ester of carbamic acid or its N-substituted derivatives." [] +subset: 3_STAR +synonym: "carbamate esters" RELATED [ChEBI] +synonym: "carbamates" RELATED [ChEBI] +xref: Wikipedia:Carbamate +is_a: CHEBI:33308 ! carboxylic ester +relationship: has_functional_parent CHEBI:28616 ! carbamic acid + [Term] id: CHEBI:23004 name: carbamoyl group @@ -5565,6 +9416,38 @@ synonym: "oxides of carbon" RELATED [ChEBI] is_a: CHEBI:25701 ! organic oxide is_a: CHEBI:36963 ! organooxygen compound +[Term] +id: CHEBI:23018 +name: EC 4.2.1.1 (carbonic anhydrase) inhibitor +namespace: chebi_ontology +def: "An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule." [] +subset: 3_STAR +synonym: "anhydrase inhibitor" RELATED [ChEBI] +synonym: "anhydrase inhibitors" RELATED [ChEBI] +synonym: "carbonate anhydrase inhibitor" RELATED [ChEBI] +synonym: "carbonate anhydrase inhibitors" RELATED [ChEBI] +synonym: "carbonate dehydratase inhibitor" RELATED [ChEBI] +synonym: "carbonate dehydratase inhibitors" RELATED [ChEBI] +synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitor" RELATED [ChEBI] +synonym: "carbonate hydro-lyase (carbon-dioxide-forming) inhibitors" RELATED [ChEBI] +synonym: "carbonate hydro-lyase inhibitor" RELATED [ChEBI] +synonym: "carbonate hydro-lyase inhibitors" RELATED [ChEBI] +synonym: "carbonic acid anhydrase inhibitor" RELATED [ChEBI] +synonym: "carbonic acid anhydrase inhibitors" RELATED [ChEBI] +synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitor" RELATED [ChEBI] +synonym: "carbonic anhydrase (EC 4.2.1.1) inhibitors" RELATED [ChEBI] +synonym: "carbonic anhydrase A inhibitor" RELATED [ChEBI] +synonym: "carbonic anhydrase A inhibitors" RELATED [ChEBI] +synonym: "carbonic anhydrase inhibitor" RELATED [ChEBI] +synonym: "carbonic anhydrase inhibitors" RELATED [ChEBI] +synonym: "carboxyanhydrase inhibitor" RELATED [ChEBI] +synonym: "carboxyanhydrase inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.1.1 (carbonic anhydrase) inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.1.1 inhibitor" RELATED [ChEBI] +synonym: "EC 4.2.1.1 inhibitors" RELATED [ChEBI] +xref: Wikipedia:Carbonic_anhydrase_inhibitor +is_a: CHEBI:76907 ! EC 4.2.1.* (hydro-lyases) inhibitor + [Term] id: CHEBI:23019 name: carbonyl group @@ -5605,6 +9488,23 @@ xref: CAS:36-88-4 {source="ChemIDplus"} is_a: CHEBI:26935 ! tetraterpenoid relationship: has_parent_hydride CHEBI:23042 ! carotene +[Term] +id: CHEBI:23089 +name: chelate-forming peptide +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:25903 ! peptide antibiotic +relationship: has_role CHEBI:38161 ! chelator + +[Term] +id: CHEBI:23114 +name: chloride salt +synonym: "chloride salts" RELATED [] +synonym: "chlorides" RELATED [] +is_a: CHEBI:23117 ! chlorine molecular entity +is_a: CHEBI:33958 ! halide salt +relationship: has_part CHEBI:17996 ! chloride + [Term] id: CHEBI:23116 name: chlorine atom @@ -5638,6 +9538,25 @@ subset: 3_STAR is_a: CHEBI:24471 ! halogen molecular entity relationship: has_part CHEBI:23116 ! chlorine atom +[Term] +id: CHEBI:23132 +name: chlorobenzenes +namespace: chebi_ontology +def: "Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines." [] +subset: 3_STAR +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:36683 ! organochlorine compound + +[Term] +id: CHEBI:23135 +name: chlorobenzophenone +namespace: chebi_ontology +def: "A member of the class of benzophenones that is any substituted benzophenone in which at least one of the substituents is a chlorine." [] +subset: 3_STAR +synonym: "chlorobenzophenones" RELATED [ChEBI] +is_a: CHEBI:22726 ! benzophenones +is_a: CHEBI:23132 ! chlorobenzenes + [Term] id: CHEBI:23213 name: choline ester @@ -5672,6 +9591,13 @@ namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38443 ! 1-benzopyran +[Term] +id: CHEBI:23232 +name: chromenes +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:38443 ! 1-benzopyran + [Term] id: CHEBI:23354 name: coenzyme @@ -5718,6 +9644,24 @@ synonym: "copper molecular entity" EXACT [ChEBI] is_a: CHEBI:33745 ! copper group molecular entity relationship: has_part CHEBI:28694 ! copper atom +[Term] +id: CHEBI:23403 +name: coumarins +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:26004 ! phenylpropanoid +is_a: CHEBI:38445 ! chromenone + +[Term] +id: CHEBI:23424 +name: cyanides +namespace: chebi_ontology +def: "Salts and C-organyl derivatives of hydrogen cyanide, HC#N." [] +subset: 3_STAR +synonym: "cyanides" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35352 ! organonitrogen compound +relationship: has_parent_hydride CHEBI:18407 ! hydrogen cyanide + [Term] id: CHEBI:23443 name: cyclic amide @@ -5740,6 +9684,14 @@ synonym: "peptido ciclico" RELATED [IUPAC] synonym: "Zyklopeptid" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide +[Term] +id: CHEBI:23480 +name: cyclohexanols +namespace: chebi_ontology +def: "An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton." [] +subset: 3_STAR +is_a: CHEBI:30879 ! alcohol + [Term] id: CHEBI:23509 name: cysteine derivative @@ -5752,6 +9704,55 @@ synonym: "cysteine derivatives" RELATED [ChEBI] is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:15356 ! cysteine +[Term] +id: CHEBI:23636 +name: deoxyribonucleoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "deoxyribonucleosides" RELATED [ChEBI] +is_a: CHEBI:33838 ! nucleoside + +[Term] +id: CHEBI:23677 +name: diazole +namespace: chebi_ontology +def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." [] +subset: 3_STAR +synonym: "diazoles" RELATED [ChEBI] +is_a: CHEBI:68452 ! azole + +[Term] +id: CHEBI:23690 +name: dicarboxylic acid amide +namespace: chebi_ontology +subset: 3_STAR +synonym: "dicarboxylic acid amides" RELATED [ChEBI] +is_a: CHEBI:37622 ! carboxamide + +[Term] +id: CHEBI:23697 +name: dichlorobenzene +namespace: chebi_ontology +def: "Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions." [] +subset: 3_STAR +synonym: "Dichlorbenzol" RELATED [ChEBI] +synonym: "dichlorobenzene" EXACT IUPAC_NAME [IUPAC] +synonym: "dichlorobenzene" EXACT [ChEBI] +synonym: "dichlorobenzenes" RELATED [ChEBI] +is_a: CHEBI:23132 ! chlorobenzenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H4Cl2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "147.002" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "145.96901" xsd:string + +[Term] +id: CHEBI:23765 +name: quinolone +namespace: chebi_ontology +subset: 3_STAR +synonym: "quinolones" RELATED [ChEBI] +is_a: CHEBI:26513 ! quinolines + [Term] id: CHEBI:23824 name: diol @@ -5904,6 +9905,14 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "246.43080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "246.23475" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CCCCC1CC[C@]1([H])[C@]2([H])CC[C@]2(C)CCC[C@@]12[H]" xsd:string +[Term] +id: CHEBI:23981 +name: ethanolamines +namespace: chebi_ontology +subset: 3_STAR +synonym: "ethanolamine" RELATED [ChEBI] +is_a: CHEBI:22478 ! amino alcohol + [Term] id: CHEBI:23982 name: ethanols @@ -5912,6 +9921,27 @@ def: "Any primary alcohol based on an ethanol skeleton." [] subset: 3_STAR is_a: CHEBI:15734 ! primary alcohol +[Term] +id: CHEBI:23990 +name: ethyl ester +namespace: chebi_ontology +alt_id: CHEBI:85056 +def: "Any carboxylic ester resulting from the formal condensation of the carboxy group of a carboxylic acid with ethanol." [] +subset: 3_STAR +synonym: "carboxylic acid ethyl ester" RELATED [ChEBI] +synonym: "carboxylic acid ethyl esters" RELATED [ChEBI] +synonym: "ethyl carboxylate" RELATED [ChEBI] +synonym: "ethyl carboxylates" RELATED [ChEBI] +synonym: "ethyl esters" RELATED [ChEBI] +is_a: CHEBI:33308 ! carboxylic ester +relationship: has_functional_parent CHEBI:16236 ! ethanol +relationship: has_functional_parent CHEBI:33575 ! carboxylic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H5O2R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "73.07060" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "73.02895" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOC([*])=O" xsd:string + [Term] id: CHEBI:24020 name: fat-soluble vitamin (role) @@ -5925,7 +9955,94 @@ xref: PMID:31838543 {source="Europe PMC"} xref: PMID:32057251 {source="Europe PMC"} xref: PMID:33549284 {source="Europe PMC"} xref: PMID:34045883 {source="Europe PMC"} -is_a: CHEBI:33229 ! vitamin (role) +is_a: CHEBI:33229 ! vitamin + +[Term] +id: CHEBI:24026 +name: fatty alcohol +namespace: chebi_ontology +def: "An aliphatic alcohol consisting of a chain of 3 to greater than 27 carbon atoms. Fatty alcohols may be saturated or unsaturated and may be branched or unbranched." [] +subset: 3_STAR +synonym: "alcool gras" RELATED [ChEBI] +synonym: "fatty alcohol" EXACT [ChEBI] +synonym: "fatty alcohols" RELATED [LIPID_MAPS] +synonym: "fatty alcohols" RELATED [ChEBI] +synonym: "Fettalkohol" RELATED [ChEBI] +synonym: "Fettalkohole" RELATED [ChEBI] +xref: LIPID_MAPS_class:LMFA05 {source="LIPID MAPS"} +xref: MetaCyc:Fatty-Alcohols +xref: Wikipedia:Fatty_alcohol +is_a: CHEBI:30879 ! alcohol +is_a: CHEBI:61697 ! fatty acid derivative +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HOR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "17.007" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[*]" xsd:string + +[Term] +id: CHEBI:24061 +name: fluorine atom +namespace: chebi_ontology +subset: 3_STAR +synonym: "9F" RELATED [IUPAC] +synonym: "F" RELATED [IUPAC] +synonym: "Fluor" RELATED [ChemIDplus] +synonym: "fluor" RELATED [ChEBI] +synonym: "fluorine" EXACT IUPAC_NAME [IUPAC] +synonym: "fluorine" RELATED [ChEBI] +synonym: "fluorum" RELATED [ChEBI] +xref: CAS:7782-41-4 {source="ChemIDplus"} +xref: WebElements:F +is_a: CHEBI:24473 ! halogen +relationship: has_role CHEBI:27027 ! micronutrient +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "F" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/F" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YCKRFDGAMUMZLT-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "18.99840" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[F]" xsd:string + +[Term] +id: CHEBI:24062 +name: fluorine molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "fluorine compounds" RELATED [ChEBI] +synonym: "fluorine molecular entities" RELATED [ChEBI] +synonym: "fluorine molecular entity" EXACT [ChEBI] +is_a: CHEBI:24471 ! halogen molecular entity +relationship: has_part CHEBI:24061 ! fluorine atom + +[Term] +id: CHEBI:24067 +name: fluoroalkane +namespace: chebi_ontology +def: "A haloalkane that is an alkane in which at least one hydrogen atom has been replaced by a fluorine atom." [] +subset: 3_STAR +synonym: "fluoroalkane" EXACT [ChEBI] +synonym: "fluoroalkanes" RELATED [ChEBI] +is_a: CHEBI:24469 ! haloalkane +is_a: CHEBI:37143 ! organofluorine compound + +[Term] +id: CHEBI:24079 +name: formamides +namespace: chebi_ontology +def: "Amides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H)." [] +subset: 3_STAR +is_a: CHEBI:37622 ! carboxamide + +[Term] +id: CHEBI:24127 +name: fungicide +namespace: chebi_ontology +def: "A substance used to destroy fungal pests." [] +subset: 3_STAR +synonym: "fungicides" RELATED [ChEBI] +is_a: CHEBI:25944 ! pesticide +is_a: CHEBI:35718 ! antifungal agent [Term] id: CHEBI:24129 @@ -5946,6 +10063,14 @@ subset: 3_STAR synonym: "glucocorticoids" RELATED [ChEBI] is_a: CHEBI:36699 ! corticosteroid hormone +[Term] +id: CHEBI:24278 +name: glucoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "glucosides" RELATED [ChEBI] +is_a: CHEBI:35313 ! hexoside + [Term] id: CHEBI:24315 name: glutamic acid derivative @@ -6015,6 +10140,30 @@ namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:37163 ! glucan +[Term] +id: CHEBI:24396 +name: glycopeptide +namespace: chebi_ontology +alt_id: CHEBI:24395 +alt_id: CHEBI:5478 +def: "Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide." [] +subset: 3_STAR +synonym: "glycopeptides" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:16670 ! peptide +is_a: CHEBI:63299 ! carbohydrate derivative + +[Term] +id: CHEBI:24400 +name: glycoside +namespace: chebi_ontology +def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." [] +subset: 3_STAR +synonym: "glycosides" EXACT IUPAC_NAME [IUPAC] +synonym: "glycosides" RELATED [ChEBI] +synonym: "O-glycoside" RELATED [ChEBI] +synonym: "O-glycosides" RELATED [ChEBI] +is_a: CHEBI:63161 ! glycosyl compound + [Term] id: CHEBI:24402 name: glycosphingolipid @@ -6049,6 +10198,7 @@ def: "A chemical entity is a physical entity of interest in chemistry including subset: 3_STAR synonym: "chemical entity" EXACT [UniProt] is_a: BFO:0000030 ! object +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24432 @@ -6059,6 +10209,7 @@ subset: 3_STAR synonym: "biological function" RELATED [ChEBI] is_a: BFO:0000023 ! role is_a: CHEBI:50906 ! role +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24433 @@ -6083,6 +10234,17 @@ def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound +[Term] +id: CHEBI:24469 +name: haloalkane +namespace: chebi_ontology +def: "A halohydrocarbon that is an alkane in which at least one hydrogen atom has been replaced by with a halogen atom." [] +subset: 3_STAR +synonym: "alkyl halide" RELATED [ChEBI] +synonym: "alkyl halides" RELATED [ChEBI] +synonym: "haloalkanes" RELATED [ChEBI] +is_a: CHEBI:24472 ! halohydrocarbon + [Term] id: CHEBI:24470 name: haloamino acid @@ -6103,6 +10265,17 @@ synonym: "halogen molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:24473 ! halogen +[Term] +id: CHEBI:24472 +name: halohydrocarbon +namespace: chebi_ontology +def: "A compound derived from a hydrocarbon by replacing a hydrogen atom with a halogen atom." [] +subset: 3_STAR +synonym: "halogenated hydrocarbons" RELATED [ChEBI] +synonym: "halohydrocarbons" RELATED [ChEBI] +is_a: CHEBI:17792 ! organohalogen compound +relationship: has_parent_hydride CHEBI:24632 ! hydrocarbon + [Term] id: CHEBI:24473 name: halogen @@ -6120,6 +10293,22 @@ synonym: "halogens" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:25585 ! nonmetal atom is_a: CHEBI:33560 ! p-block element atom +[Term] +id: CHEBI:24505 +name: heparins +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:35722 ! sulfated glycosaminoglycan +is_a: CHEBI:37395 ! mucopolysaccharide + +[Term] +id: CHEBI:24531 +name: heterocyclic antibiotic +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:24532 ! organic heterocyclic compound +relationship: has_role CHEBI:33281 ! antimicrobial agent + [Term] id: CHEBI:24532 name: organic heterocyclic compound @@ -6144,6 +10333,21 @@ synonym: "peptide cyclique heterodetique" RELATED [IUPAC] synonym: "peptido ciclico heterodetico" RELATED [IUPAC] is_a: CHEBI:23449 ! cyclic peptide +[Term] +id: CHEBI:24580 +name: hexenoic acid +namespace: chebi_ontology +def: "A C6, medium-chain fatty acid carrying a double bond at any position along the main chain." [] +subset: 3_STAR +synonym: "hexenoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "hexenoic acids" RELATED [ChEBI] +is_a: CHEBI:25413 ! monounsaturated fatty acid +is_a: CHEBI:59554 ! medium-chain fatty acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "114.143" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.06808" xsd:string + [Term] id: CHEBI:24610 name: homocysteines @@ -6151,6 +10355,18 @@ namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid +[Term] +id: CHEBI:24613 +name: homodetic cyclic peptide +namespace: chebi_ontology +def: "A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages." [] +subset: 3_STAR +synonym: "homodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC] +synonym: "homodetic cyclic peptides" RELATED [ChEBI] +synonym: "peptide cyclique homodetique" RELATED [IUPAC] +synonym: "peptido ciclico homodetico" RELATED [IUPAC] +is_a: CHEBI:23449 ! cyclic peptide + [Term] id: CHEBI:24621 name: hormone @@ -6162,6 +10378,14 @@ synonym: "hormones" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger is_a: CHEBI:48705 ! agonist +[Term] +id: CHEBI:24628 +name: imidazolidine-2,4-dione +namespace: chebi_ontology +def: "An imidazolidinone with oxo groups at position 2 and 4." [] +subset: 3_STAR +is_a: CHEBI:55370 ! imidazolidinone + [Term] id: CHEBI:24632 name: hydrocarbon @@ -6188,6 +10412,17 @@ is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity relationship: has_part CHEBI:43176 ! hydroxy group +[Term] +id: CHEBI:24663 +name: hydroxy-5beta-cholanic acid +namespace: chebi_ontology +def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." [] +subset: 3_STAR +synonym: "hydroxy-5beta-cholanic acids" RELATED [ChEBI] +is_a: CHEBI:33822 ! organic hydroxy compound +is_a: CHEBI:36248 ! 5beta-cholanic acids +relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid + [Term] id: CHEBI:24669 name: hydroxy carboxylic acid @@ -6200,6 +10435,51 @@ synonym: "hydroxycarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33822 ! organic hydroxy compound +[Term] +id: CHEBI:24675 +name: hydroxybenzoate +namespace: chebi_ontology +def: "Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent." [] +subset: 3_STAR +synonym: "hydroxybenzoates" RELATED [ChEBI] +is_a: CHEBI:22718 ! benzoates +is_a: CHEBI:36059 ! hydroxy monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:24676 ! hydroxybenzoic acid + +[Term] +id: CHEBI:24676 +name: hydroxybenzoic acid +namespace: chebi_ontology +alt_id: CHEBI:50778 +def: "Any benzoic acid carrying one or more phenolic hydroxy groups on the benzene ring." [] +subset: 3_STAR +synonym: "hydroxybenzoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "hydroxybenzoic acids" RELATED [ChEBI] +is_a: CHEBI:22723 ! benzoic acids +is_a: CHEBI:33853 ! phenols +relationship: has_functional_parent CHEBI:30746 ! benzoic acid +relationship: is_conjugate_acid_of CHEBI:24675 ! hydroxybenzoate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "138.121" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "138.03169" xsd:string + +[Term] +id: CHEBI:24709 +name: hydroxylamines +namespace: chebi_ontology +def: "Hydroxylamine, H2N-OH, and its hydrocarbyl derivatives." [] +subset: 3_STAR +is_a: CHEBI:51143 ! nitrogen molecular entity + +[Term] +id: CHEBI:24780 +name: imidazoles +namespace: chebi_ontology +def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [] +subset: 3_STAR +is_a: CHEBI:23677 ! diazole + [Term] id: CHEBI:24782 name: imide @@ -6217,6 +10497,13 @@ def: "Any compound containing an indole skeleton." [] subset: 3_STAR is_a: CHEBI:22728 ! benzopyrrole +[Term] +id: CHEBI:24829 +name: indolones +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:24828 ! indoles + [Term] id: CHEBI:24833 name: oxoacid @@ -6264,6 +10551,24 @@ synonym: "inorganic oxides" RELATED [ChEBI] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide +[Term] +id: CHEBI:24839 +name: inorganic salt +synonym: "anorganisches Salz" RELATED [] +synonym: "inorganic salts" RELATED [] +is_a: CHEBI:24835 ! inorganic molecular entity +is_a: CHEBI:24866 ! salt + +[Term] +id: CHEBI:24852 +name: insecticide +namespace: chebi_ontology +def: "Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects." [] +subset: 3_STAR +synonym: "insecticides" RELATED [ChEBI] +xref: Wikipedia:Insecticide +is_a: CHEBI:25944 ! pesticide + [Term] id: CHEBI:24859 name: iodine atom @@ -6429,6 +10734,15 @@ xref: PMID:12769708 {source="Europe PMC"} xref: PMID:19219049 {source="Europe PMC"} is_a: CHEBI:18059 ! lipid +[Term] +id: CHEBI:24921 +name: isoquinoline alkaloid +namespace: chebi_ontology +def: "Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine." [] +subset: 3_STAR +synonym: "isoquinoline alkaloids" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid + [Term] id: CHEBI:24961 name: ketoaldonate @@ -6539,6 +10853,17 @@ xref: PMID:9561094 {source="Europe PMC"} is_a: CHEBI:23899 ! icosanoid relationship: is_conjugate_acid_of CHEBI:62942 ! leukotriene anion +[Term] +id: CHEBI:25036 +name: lignan +namespace: chebi_ontology +alt_id: CHEBI:25035 +def: "Any phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an \"e\"." [] +subset: 3_STAR +synonym: "lignan" EXACT [ChEBI] +synonym: "lignans" RELATED [ChEBI] +is_a: CHEBI:26004 ! phenylpropanoid + [Term] id: CHEBI:25046 name: linear tetrapyrrole @@ -6546,6 +10871,20 @@ namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26932 ! tetrapyrrole +[Term] +id: CHEBI:25106 +name: macrolide +namespace: chebi_ontology +def: "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide." [] +subset: 3_STAR +synonym: "macrolide" EXACT [ChEBI] +synonym: "macrolides" EXACT IUPAC_NAME [IUPAC] +synonym: "macrolides" RELATED [ChEBI] +synonym: "Makrolid" RELATED [ChEBI] +xref: Wikipedia:Macrolide +is_a: CHEBI:26188 ! polyketide +is_a: CHEBI:63944 ! macrocyclic lactone + [Term] id: CHEBI:25107 name: magnesium atom @@ -6557,6 +10896,7 @@ synonym: "Magnesium" RELATED [ChEBI] synonym: "magnesium" EXACT IUPAC_NAME [IUPAC] synonym: "magnesium" RELATED [ChEBI] synonym: "Mg" RELATED [IUPAC] +synonym: "Mg" RELATED [UniProt] xref: CAS:7439-95-4 {source="ChemIDplus"} xref: DrugBank:DB01378 xref: Gmelin:16207 {source="Gmelin"} @@ -6607,6 +10947,15 @@ is_a: CHEBI:26214 ! porphyrins is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33909 ! metallotetrapyrrole +[Term] +id: CHEBI:25235 +name: monomethoxybenzene +namespace: chebi_ontology +def: "Compounds containing a benzene skeleton substituted with one methoxy group." [] +subset: 3_STAR +synonym: "monomethoxybenzenes" RELATED [ChEBI] +is_a: CHEBI:51683 ! methoxybenzenes + [Term] id: CHEBI:25248 name: methyl ester @@ -6632,6 +10981,16 @@ subset: 3_STAR synonym: "mineralocorticoids" RELATED [ChEBI] is_a: CHEBI:36699 ! corticosteroid hormone +[Term] +id: CHEBI:25355 +name: mitochondrial respiratory-chain inhibitor +namespace: chebi_ontology +subset: 3_STAR +synonym: "mitochondrial electron transport chain inhibitors" RELATED [ChEBI] +synonym: "mitochondrial electron-transport chain inhibitor" RELATED [ChEBI] +synonym: "mitochondrial respiratory chain inhibitors" RELATED [ChEBI] +is_a: CHEBI:38497 ! respiratory-chain inhibitor + [Term] id: CHEBI:25362 name: elemental molecule @@ -6677,6 +11036,26 @@ synonym: "monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:33575 ! carboxylic acid relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion +[Term] +id: CHEBI:25388 +name: monohydroxybenzoate +namespace: chebi_ontology +def: "A hydroxybenzoate carrying a single hydroxy substituent at unspecified position." [] +subset: 3_STAR +synonym: "monohydroxybenzoates" RELATED [ChEBI] +is_a: CHEBI:24675 ! hydroxybenzoate +relationship: is_conjugate_base_of CHEBI:25389 ! monohydroxybenzoic acid + +[Term] +id: CHEBI:25389 +name: monohydroxybenzoic acid +namespace: chebi_ontology +def: "Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring." [] +subset: 3_STAR +synonym: "monohydroxybenzoic acids" RELATED [ChEBI] +is_a: CHEBI:24676 ! hydroxybenzoic acid +relationship: is_conjugate_acid_of CHEBI:25388 ! monohydroxybenzoate + [Term] id: CHEBI:25413 name: monounsaturated fatty acid @@ -6703,6 +11082,50 @@ property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*+]" xsd:string +[Term] +id: CHEBI:25418 +name: morphinane alkaloid +namespace: chebi_ontology +def: "An isoquinoline alkaloid based on a morphinan skeleton and its substituted derivatives." [] +subset: 3_STAR +synonym: "morphinane alkaloids" RELATED [ChEBI] +is_a: CHEBI:24921 ! isoquinoline alkaloid + +[Term] +id: CHEBI:25435 +name: mutagen +namespace: chebi_ontology +def: "An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution." [] +subset: 3_STAR +synonym: "mutagene" RELATED [ChEBI] +synonym: "mutagenes" RELATED [ChEBI] +synonym: "mutagenic agent" RELATED [ChEBI] +synonym: "mutageno" RELATED [ChEBI] +synonym: "mutagenos" RELATED [ChEBI] +synonym: "mutagens" RELATED [ChEBI] +xref: Wikipedia:Mutagen +is_a: CHEBI:50902 ! genotoxin + +[Term] +id: CHEBI:25442 +name: mycotoxin +namespace: chebi_ontology +def: "Poisonous substance produced by fungi." [] +subset: 3_STAR +synonym: "fungal toxins" RELATED [ChEBI] +synonym: "mycotoxins" RELATED [ChEBI] +is_a: CHEBI:27026 ! toxin +is_a: CHEBI:76946 ! fungal metabolite + +[Term] +id: CHEBI:25477 +name: naphthalenes +namespace: chebi_ontology +def: "Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings." [] +subset: 3_STAR +is_a: CHEBI:33836 ! benzenoid aromatic compound +is_a: CHEBI:36785 ! carbobicyclic compound + [Term] id: CHEBI:25500 name: neopterins @@ -6741,6 +11164,15 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "14.007" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string +[Term] +id: CHEBI:25558 +name: organonitrogen heterocyclic antibiotic +namespace: chebi_ontology +subset: 3_STAR +synonym: "organonitrogen heterocyclic antibiotics" RELATED [ChEBI] +is_a: CHEBI:24531 ! heterocyclic antibiotic +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + [Term] id: CHEBI:25585 name: nonmetal atom @@ -6764,7 +11196,7 @@ namespace: chebi_ontology def: "A long-chain, unsaturated fatty acid anion formed by deprotonation of the carboxy group of any octadecadienoic acid; major species at pH 7.3." [] subset: 3_STAR synonym: "octadecadienoate" EXACT IUPAC_NAME [IUPAC] -is_a: CHEBI:57560 ! long-chain fatty acid anion +is_a: CHEBI:131860 ! octadecanoid anion is_a: CHEBI:76567 ! polyunsaturated fatty acid anion relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:25627 ! octadecadienoic acid @@ -6786,8 +11218,9 @@ synonym: "FA (18:2)" RELATED [ChEBI] synonym: "octadecadienoic acid" EXACT IUPAC_NAME [IUPAC] xref: CAS:26764-25-0 {source="ChemIDplus"} xref: PMID:6794350 {source="Europe PMC"} -is_a: CHEBI:15904 ! long-chain fatty acid +is_a: CHEBI:140949 ! fatty acid 18:2 is_a: CHEBI:26208 ! polyunsaturated fatty acid +is_a: CHEBI:36326 ! octadecanoid is_a: CHEBI:53339 ! olefinic fatty acid is_a: CHEBI:59202 ! straight-chain fatty acid relationship: is_conjugate_acid_of CHEBI:25626 ! octadecadienoate @@ -6983,6 +11416,24 @@ synonym: "oxides" RELATED [ChEBI] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity +[Term] +id: CHEBI:25750 +name: oxime +namespace: chebi_ontology +def: "Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes." [] +subset: 3_STAR +synonym: "oxime" EXACT [IUPAC] +synonym: "oximes" EXACT IUPAC_NAME [IUPAC] +synonym: "oximes" RELATED [ChEBI] +is_a: CHEBI:50860 ! organic molecular entity +is_a: CHEBI:51143 ! nitrogen molecular entity +relationship: is_conjugate_acid_of CHEBI:142513 ! oxime anion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHNOR2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "43.02470" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.00581" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O\\N=C(\\[*])[*]" xsd:string + [Term] id: CHEBI:2580 name: unsaturated fatty acid anion @@ -7027,6 +11478,13 @@ synonym: "oxygen molecular entity" EXACT [ChEBI] is_a: CHEBI:33304 ! chalcogen molecular entity relationship: has_part CHEBI:25805 ! oxygen atom +[Term] +id: CHEBI:25807 +name: organooxygen heterocyclic antibiotic +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:24531 ! heterocyclic antibiotic + [Term] id: CHEBI:25810 name: oxopurine @@ -7035,6 +11493,28 @@ subset: 3_STAR synonym: "oxopurines" RELATED [ChEBI] is_a: CHEBI:26401 ! purines +[Term] +id: CHEBI:25830 +name: p-quinones +namespace: chebi_ontology +def: "A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring." [] +subset: 3_STAR +synonym: "p-quinone" RELATED [ChEBI] +synonym: "para-quinones" RELATED [ChEBI] +is_a: CHEBI:36141 ! quinone + +[Term] +id: CHEBI:25903 +name: peptide antibiotic +namespace: chebi_ontology +def: "A chemically diverse class of peptides that exhibit antimicrobial properties." [] +subset: 3_STAR +synonym: "peptide antibiotics" RELATED [ChEBI] +xref: MetaCyc:Peptide-Antibiotics +xref: PMID:33398258 {source="Europe PMC"} +is_a: CHEBI:16670 ! peptide +relationship: has_role CHEBI:33281 ! antimicrobial agent + [Term] id: CHEBI:25905 name: peptide hormone @@ -7046,6 +11526,28 @@ synonym: "polypeptide hormone" RELATED [ChEBI] is_a: CHEBI:16670 ! peptide relationship: has_role CHEBI:24621 ! hormone +[Term] +id: CHEBI:25944 +name: pesticide +namespace: chebi_ontology +def: "Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests." [] +subset: 3_STAR +synonym: "pesticide" EXACT IUPAC_NAME [IUPAC] +synonym: "pesticides" RELATED [ChEBI] +synonym: "Pestizid" RELATED [ChEBI] +synonym: "Pestizide" RELATED [ChEBI] +xref: Wikipedia:Pesticide +is_a: CHEBI:33232 ! application + +[Term] +id: CHEBI:25978 +name: phenylacetic acids +namespace: chebi_ontology +def: "Any monocarboxylic acid that is phenylacetic acid or its substituted derivatives." [] +subset: 3_STAR +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:25384 ! monocarboxylic acid + [Term] id: CHEBI:25985 name: phenylalanine derivative @@ -7055,6 +11557,24 @@ subset: 3_STAR is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:28044 ! phenylalanine +[Term] +id: CHEBI:25990 +name: phenylethanolamines +namespace: chebi_ontology +def: "An ethanolamine compound having a phenyl (substituted or unsubstituted) group on the carbon bearing the hydroxy substituent." [] +subset: 3_STAR +is_a: CHEBI:23981 ! ethanolamines + +[Term] +id: CHEBI:26004 +name: phenylpropanoid +namespace: chebi_ontology +def: "Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin." [] +subset: 3_STAR +synonym: "phenylpropanoids" RELATED [ChEBI] +xref: Wikipedia:Phenylpropanoid +is_a: CHEBI:33659 ! organic aromatic compound + [Term] id: CHEBI:26013 name: pheromone @@ -7079,6 +11599,15 @@ synonym: "phosphates" EXACT IUPAC_NAME [IUPAC] synonym: "phosphates" RELATED [ChEBI] is_a: CHEBI:26079 ! phosphoric acid derivative +[Term] +id: CHEBI:26069 +name: phosphonic acids +namespace: chebi_ontology +def: "HP(=O)(OH)2 (phosphonic acid) and its P-substituted derivatives." [] +subset: 3_STAR +synonym: "phosphonic acids" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives + [Term] id: CHEBI:26078 name: phosphoric acid @@ -7177,6 +11706,31 @@ subset: 3_STAR synonym: "pigments" RELATED [ChEBI] is_a: CHEBI:52208 ! biophysical role +[Term] +id: CHEBI:26144 +name: piperazines +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:26151 +name: piperidines +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:26155 +name: plant growth regulator +namespace: chebi_ontology +def: "A chemical, natural or artificial, that can affect the rate of growth of a plant." [] +subset: 3_STAR +synonym: "plant growth regulators" RELATED [ChEBI] +is_a: CHEBI:39317 ! growth regulator + [Term] id: CHEBI:26167 name: polar amino acid @@ -7198,6 +11752,16 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(C(*)N)=O" xsd:string +[Term] +id: CHEBI:26188 +name: polyketide +namespace: chebi_ontology +def: "Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides." [] +subset: 3_STAR +synonym: "polyketide" EXACT [ChEBI] +synonym: "polyketides" RELATED [ChEBI] +is_a: CHEBI:36963 ! organooxygen compound + [Term] id: CHEBI:26191 name: polyol @@ -7336,6 +11900,18 @@ is_a: CHEBI:26347 ! prostanoid relationship: has_functional_parent CHEBI:8504 ! prostanoic acid relationship: is_conjugate_acid_of CHEBI:59326 ! prostaglandin carboxylic acid anion +[Term] +id: CHEBI:2634 +name: amidine +namespace: chebi_ontology +def: "Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. In organic chemistry an unspecified amidine is commonly a carboxamidine." [] +subset: 3_STAR +synonym: "amidine" EXACT [IUPAC] +synonym: "Amidines" RELATED [KEGG_COMPOUND] +synonym: "amidines" EXACT IUPAC_NAME [IUPAC] +synonym: "amidines" RELATED [ChEBI] +is_a: CHEBI:51143 ! nitrogen molecular entity + [Term] id: CHEBI:26347 name: prostanoid @@ -7388,6 +11964,85 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C5N4R7" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "116.080" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.01230" xsd:string +[Term] +id: CHEBI:26407 +name: pyrans +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38104 ! oxacycle + +[Term] +id: CHEBI:26410 +name: pyrazoles +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:23677 ! diazole + +[Term] +id: CHEBI:26416 +name: pyridine alkaloid +namespace: chebi_ontology +subset: 3_STAR +synonym: "pyridine alkaloids" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid +is_a: CHEBI:26421 ! pyridines + +[Term] +id: CHEBI:26421 +name: pyridines +namespace: chebi_ontology +def: "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." [] +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:26432 +name: pyrimidine nucleobase +namespace: chebi_ontology +def: "A nucleobase whose skeleton is derived from pyrimidine." [] +subset: 3_STAR +synonym: "a pyrimidine nucleobase" RELATED [UniProt] +synonym: "pyrimidine bases" RELATED [ChEBI] +synonym: "pyrimidine nucleobase" EXACT [ChEBI] +synonym: "pyrimidine nucleobases" RELATED [ChEBI] +is_a: CHEBI:18282 ! nucleobase +is_a: CHEBI:39447 ! pyrimidines +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4HN2R4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "77.064" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "77.01397" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1C(=C(C(=NC1=*)*)*)*" xsd:string + +[Term] +id: CHEBI:26440 +name: pyrimidine nucleoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG_COMPOUND] +synonym: "pyrimidine nucleosides" RELATED [ChEBI] +xref: KEGG:C03169 +is_a: CHEBI:33838 ! nucleoside +is_a: CHEBI:39447 ! pyrimidines + +[Term] +id: CHEBI:26455 +name: pyrroles +namespace: chebi_ontology +def: "An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton." [] +subset: 3_STAR +is_a: CHEBI:68452 ! azole + +[Term] +id: CHEBI:26456 +name: pyrrolidine alkaloid +namespace: chebi_ontology +subset: 3_STAR +synonym: "pyrrolidine alkaloids" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid +is_a: CHEBI:38260 ! pyrrolidines + [Term] id: CHEBI:26469 name: quaternary nitrogen compound @@ -7397,6 +12052,23 @@ subset: 3_STAR is_a: CHEBI:35352 ! organonitrogen compound relationship: has_part CHEBI:35267 ! quaternary ammonium ion +[Term] +id: CHEBI:26509 +name: quinoline alkaloid +namespace: chebi_ontology +subset: 3_STAR +synonym: "quinoline alkaloids" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid + +[Term] +id: CHEBI:26513 +name: quinolines +namespace: chebi_ontology +def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring." [] +subset: 3_STAR +is_a: CHEBI:33659 ! organic aromatic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + [Term] id: CHEBI:26537 name: retinoid @@ -7408,6 +12080,25 @@ synonym: "retinoids" EXACT IUPAC_NAME [IUPAC] synonym: "retinoids" RELATED [ChEBI] is_a: CHEBI:23849 ! diterpenoid +[Term] +id: CHEBI:26580 +name: rifamycins +namespace: chebi_ontology +subset: 3_STAR +synonym: "rifamycin" RELATED [ChEBI] +xref: Wikipedia:Rifamycin +is_a: CHEBI:22565 ! ansamycin +is_a: CHEBI:39270 ! naphthofuran + +[Term] +id: CHEBI:26596 +name: salicylates +namespace: chebi_ontology +def: "Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid." [] +subset: 3_STAR +xref: PMID:22866967 {source="Europe PMC"} +is_a: CHEBI:36963 ! organooxygen compound + [Term] id: CHEBI:26607 name: saturated fatty acid @@ -7467,6 +12158,17 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "45.017" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string +[Term] +id: CHEBI:26677 +name: silicon molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "silicon compounds" RELATED [ChEBI] +synonym: "silicon molecular entities" RELATED [ChEBI] +synonym: "silicon molecular entity" EXACT [ChEBI] +is_a: CHEBI:33582 ! carbon group molecular entity +relationship: has_part CHEBI:27573 ! silicon atom + [Term] id: CHEBI:26708 name: sodium atom @@ -7494,6 +12196,27 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98977" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na]" xsd:string +[Term] +id: CHEBI:26710 +name: sodium chloride +def: "An inorganic chloride salt having sodium(1+) as the counterion." [] +synonym: "chlorure de sodium" RELATED [] +synonym: "cloruro sodico" RELATED [] +synonym: "common salt" RELATED [] +synonym: "halite" RELATED [] +synonym: "Kochsalz" RELATED [] +synonym: "NaCl" RELATED [] +synonym: "natrii chloridum" RELATED [] +synonym: "Natriumchlorid" RELATED [] +synonym: "rock salt" RELATED [] +synonym: "salt" RELATED [] +synonym: "sodium chloride" EXACT [] +synonym: "table salt" RELATED [] +is_a: CHEBI:36093 ! inorganic chloride +is_a: CHEBI:38702 ! inorganic sodium salt +relationship: has_role CHEBI:149552 ! emetic +relationship: has_role CHEBI:79314 ! flame retardant + [Term] id: CHEBI:26712 name: sodium molecular entity @@ -7579,6 +12302,45 @@ synonym: "Steroidhormone" RELATED [ChEBI] is_a: CHEBI:35341 ! steroid relationship: has_role CHEBI:24621 ! hormone +[Term] +id: CHEBI:26775 +name: stilbene +namespace: chebi_ontology +subset: 3_STAR +synonym: "1,1'-(1,2-ethenediyl)bis[benzene]" RELATED [NIST_Chemistry_WebBook] +synonym: "1,1'-(1,2-ethenediyl)bisbenzene" RELATED [ChemIDplus] +synonym: "1,1'-(1,2-ethenediyl)dibenzene" RELATED [ChemIDplus] +synonym: "1,1'-(ethene-1,2-diyl)dibenzene" EXACT IUPAC_NAME [IUPAC] +synonym: "1,1'-ethene-1,2-diyldibenzene" RELATED [ChEBI] +synonym: "1,2-diphenylethylene" RELATED [NIST_Chemistry_WebBook] +synonym: "alpha,beta-diphenylethylene" RELATED [NIST_Chemistry_WebBook] +synonym: "stilbene" EXACT [ChemIDplus] +xref: Beilstein:1904445 {source="ChemIDplus"} +xref: CAS:588-59-0 {source="NIST Chemistry WebBook"} +xref: CAS:588-59-0 {source="ChemIDplus"} +xref: Gmelin:67845 {source="Gmelin"} +xref: Wikipedia:Stilbene +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:78840 ! olefinic compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H12/c1-3-7-13(8-4-1)11-12-14-9-5-2-6-10-14/h1-12H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJANXHGTPQOBST-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.24508" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.09390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])c1ccccc1)c1ccccc1" xsd:string + +[Term] +id: CHEBI:26776 +name: stilbenoid +namespace: chebi_ontology +def: "Any olefinic compound characterised by a 1,2-diphenylethylene backbone." [] +subset: 3_STAR +synonym: "stilbenes" RELATED [ChEBI] +synonym: "stilbenoids" RELATED [ChEBI] +is_a: CHEBI:33659 ! organic aromatic compound +is_a: CHEBI:78840 ! olefinic compound + [Term] id: CHEBI:26819 name: sulfuric ester @@ -7607,6 +12369,15 @@ synonym: "sulfuric acid derivative" RELATED [ChEBI] synonym: "sulphates" RELATED [ChEBI] is_a: CHEBI:37826 ! sulfuric acid derivative +[Term] +id: CHEBI:26822 +name: sulfide +namespace: chebi_ontology +def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." [] +subset: 3_STAR +synonym: "sulphides" RELATED [ChEBI] +is_a: CHEBI:26835 ! sulfur molecular entity + [Term] id: CHEBI:26829 name: sulfoglycolipid @@ -7763,6 +12534,15 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "71.09780" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "71.04969" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(C[*])(C[*])C[*]" xsd:string +[Term] +id: CHEBI:26912 +name: oxolanes +namespace: chebi_ontology +def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." [] +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38104 ! oxacycle + [Term] id: CHEBI:26932 name: tetrapyrrole @@ -7807,6 +12587,26 @@ is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:63048 ! 1,3-thiazolium cation is_a: CHEBI:75769 ! B vitamin +[Term] +id: CHEBI:26961 +name: thiophenes +namespace: chebi_ontology +def: "Compounds containing at least one thiophene ring." [] +subset: 3_STAR +is_a: CHEBI:38106 ! organosulfur heterocyclic compound + +[Term] +id: CHEBI:26979 +name: organic heterotricyclic compound +namespace: chebi_ontology +def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." [] +subset: 3_STAR +synonym: "heterotricyclic compounds" RELATED [ChEBI] +synonym: "organic heterotricyclic compounds" RELATED [ChEBI] +is_a: CHEBI:36688 ! heterotricyclic compound +is_a: CHEBI:38166 ! organic heteropolycyclic compound +is_a: CHEBI:51959 ! organic tricyclic compound + [Term] id: CHEBI:26995 name: thromboxane @@ -7954,6 +12754,18 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4O3" xsd:stri property_value: http://purl.obolibrary.org/obo/chebi/mass "168.11042" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "168.02834" xsd:string +[Term] +id: CHEBI:27288 +name: vinca alkaloid +namespace: chebi_ontology +def: "A group of indole-indoline dimers which are alkaloids obtained from the Vinca genus of plants, together with semi-synthetic and fully synthetic analogues." [] +subset: 3_STAR +synonym: "vinca alkaloid" EXACT [ChEBI] +synonym: "vinca alkaloids" RELATED [ChEBI] +synonym: "vincaleukoblastines" RELATED [ChEBI] +xref: Wikipedia:Vinca_alkaloid +is_a: CHEBI:65323 ! monoterpenoid indole alkaloid + [Term] id: CHEBI:27300 name: vitamin D @@ -7972,6 +12784,7 @@ relationship: has_role CHEBI:24020 ! fat-soluble vitamin (role) [Term] id: CHEBI:27314 +name: water-soluble vitamin name: water-soluble vitamin (role) namespace: chebi_ontology def: "Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine." [] @@ -7979,7 +12792,7 @@ subset: 3_STAR synonym: "wasserloesliche Vitamine" RELATED [ChEBI] synonym: "water-soluble vitamin" RELATED [ChEBI] synonym: "water-soluble vitamins" RELATED [ChEBI] -is_a: CHEBI:33229 ! vitamin (role) +is_a: CHEBI:33229 ! vitamin [Term] id: CHEBI:27369 @@ -7995,6 +12808,42 @@ synonym: "zwitterionic compounds" RELATED [IUPAC] synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:51151 ! dipolar compound +[Term] +id: CHEBI:27375 +name: vincaleukoblastine +namespace: chebi_ontology +alt_id: CHEBI:27287 +alt_id: CHEBI:46447 +alt_id: CHEBI:9983 +subset: 3_STAR +synonym: "(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE" RELATED [PDBeChem] +synonym: "Vinblastine" RELATED [KEGG_COMPOUND] +synonym: "vincaleukoblastine" EXACT IUPAC_NAME [IUPAC] +synonym: "VLB" RELATED [ChemIDplus] +xref: Beilstein:4779207 {source="Beilstein"} +xref: CAS:865-21-4 {source="ChemIDplus"} +xref: CAS:865-21-4 {source="KEGG COMPOUND"} +xref: DrugBank:DB00570 +xref: KEGG:C07201 +xref: KEGG:D08675 +xref: KNApSAcK:C00001781 +xref: PDBeChem:VLB +is_a: CHEBI:25248 ! methyl ester +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:27288 ! vinca alkaloid +is_a: CHEBI:38163 ! organic heterotetracyclic compound +is_a: CHEBI:38164 ! organic heteropentacyclic compound +is_a: CHEBI:38482 ! indole alkaloid fundamental parent +is_a: CHEBI:47622 ! acetate ester +is_a: CHEBI:50996 ! tertiary amino compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H58N4O9" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JXLYSJRDGCGARV-XQKSVPLYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "810.97410" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "810.42038" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2CN(CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC" xsd:string + [Term] id: CHEBI:27470 name: folic acid @@ -8098,6 +12947,94 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "441.39750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "441.13968" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nc2ncc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2c(=O)[nH]1" xsd:string +[Term] +id: CHEBI:27560 +name: boron atom +namespace: chebi_ontology +alt_id: CHEBI:22915 +alt_id: CHEBI:3152 +subset: 3_STAR +synonym: "5B" RELATED [IUPAC] +synonym: "B" RELATED [KEGG_COMPOUND] +synonym: "Bor" RELATED [ChEBI] +synonym: "boracium" RELATED [ChEBI] +synonym: "bore" RELATED [ChEBI] +synonym: "boro" RELATED [ChEBI] +synonym: "Boron" RELATED [KEGG_COMPOUND] +synonym: "boron" EXACT IUPAC_NAME [IUPAC] +synonym: "boron" RELATED [ChEBI] +xref: CAS:7440-42-8 {source="ChemIDplus"} +xref: CAS:7440-42-8 {source="KEGG COMPOUND"} +xref: KEGG:C06266 +xref: WebElements:B +is_a: CHEBI:137980 ! metalloid atom +is_a: CHEBI:25585 ! nonmetal atom +is_a: CHEBI:33317 ! boron group element atom +relationship: has_role CHEBI:27027 ! micronutrient +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "B" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/B" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZOXJGFHDIHLPTG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "10.81100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "11.00930" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[B]" xsd:string + +[Term] +id: CHEBI:27561 +name: oxirane +namespace: chebi_ontology +alt_id: CHEBI:24001 +alt_id: CHEBI:4900 +def: "A saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom." [] +subset: 3_STAR +synonym: "1,2-Epoxyaethan" RELATED [ChemIDplus] +synonym: "1,2-epoxyethane" RELATED [NIST_Chemistry_WebBook] +synonym: "Aethylenoxid" RELATED [ChemIDplus] +synonym: "Amprolene" RELATED [ChemIDplus] +synonym: "Anprolene" RELATED [NIST_Chemistry_WebBook] +synonym: "Anproline" RELATED [ChemIDplus] +synonym: "Dihydrooxirene" RELATED [ChemIDplus] +synonym: "Dimethylene oxide" RELATED [ChemIDplus] +synonym: "epoxyethane" RELATED [NIST_Chemistry_WebBook] +synonym: "ethene oxide" RELATED [NIST_Chemistry_WebBook] +synonym: "Ethylene oxide" RELATED [KEGG_COMPOUND] +synonym: "ETO" RELATED [ChemIDplus] +synonym: "Oxacyclopropane" RELATED [ChemIDplus] +synonym: "Oxane" RELATED [ChemIDplus] +synonym: "Oxidoethane" RELATED [ChemIDplus] +synonym: "oxirane" EXACT IUPAC_NAME [IUPAC] +synonym: "oxyde d'ethylene" RELATED [ChemIDplus] +synonym: "Oxyfume" RELATED [ChEBI] +xref: Beilstein:102378 {source="Beilstein"} +xref: CAS:75-21-8 {source="NIST Chemistry WebBook"} +xref: CAS:75-21-8 {source="KEGG COMPOUND"} +xref: CAS:75-21-8 {source="ChemIDplus"} +xref: Gmelin:676 {source="Gmelin"} +xref: HMDB:HMDB0031305 +xref: KEGG:C06548 +xref: KEGG:D03474 +xref: PMID:11437638 {source="Europe PMC"} +xref: PMID:24313866 {source="Europe PMC"} +xref: PMID:24882394 {source="Europe PMC"} +xref: PMID:25005741 {source="Europe PMC"} +xref: PMID:3932500 {source="Europe PMC"} +xref: Reaxys:102378 {source="Reaxys"} +xref: UM-BBD_compID:c0527 {source="UM-BBD"} +xref: Wikipedia:Oxirane +is_a: CHEBI:138675 ! gas molecular entity +is_a: CHEBI:36389 ! saturated organic heteromonocyclic parent +is_a: CHEBI:38104 ! oxacycle +relationship: has_role CHEBI:25435 ! mutagen +relationship: has_role CHEBI:50904 ! allergen +relationship: has_role CHEBI:75771 ! mouse metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O/c1-2-3-1/h1-2H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IAYPIBMASNFSPL-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "44.05256" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.02621" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1CO1" xsd:string + [Term] id: CHEBI:27568 name: selenium atom @@ -8131,6 +13068,36 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "78.96000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.91652" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Se]" xsd:string +[Term] +id: CHEBI:27573 +name: silicon atom +namespace: chebi_ontology +alt_id: CHEBI:26676 +alt_id: CHEBI:9140 +subset: 3_STAR +synonym: "14Si" RELATED [IUPAC] +synonym: "Si" RELATED [KEGG_COMPOUND] +synonym: "Si" RELATED [IUPAC] +synonym: "silicio" RELATED [ChEBI] +synonym: "silicium" RELATED [ChEBI] +synonym: "Silicon" RELATED [KEGG_COMPOUND] +synonym: "silicon" EXACT IUPAC_NAME [IUPAC] +synonym: "silicon" RELATED [ChEBI] +synonym: "Silizium" RELATED [ChEBI] +xref: CAS:7440-21-3 {source="ChemIDplus"} +xref: KEGG:C06263 +xref: WebElements:Si +is_a: CHEBI:137980 ! metalloid atom +is_a: CHEBI:25585 ! nonmetal atom +is_a: CHEBI:33306 ! carbon group element atom +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "Si" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Si" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUIMIQQOPSSXEZ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "28.08550" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.97693" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Si]" xsd:string + [Term] id: CHEBI:27584 name: aldosterone @@ -8214,6 +13181,84 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "12.01070" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "12.00000" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C]" xsd:string +[Term] +id: CHEBI:27612 +name: hydantoin +namespace: chebi_ontology +alt_id: CHEBI:24625 +alt_id: CHEBI:5773 +subset: 3_STAR +synonym: "2,4(3H,5H)-imidazoledione" RELATED [NIST_Chemistry_WebBook] +synonym: "2,4-imidazolidinedione" RELATED [NIST_Chemistry_WebBook] +synonym: "Glycolylurea" RELATED [KEGG_COMPOUND] +synonym: "Hydantoin" EXACT [KEGG_COMPOUND] +synonym: "imidazole-2,4(3H,5H)-dione" RELATED [ChemIDplus] +synonym: "imidazolidine-2,4-dione" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:110598 {source="Beilstein"} +xref: CAS:461-72-3 {source="ChemIDplus"} +xref: CAS:461-72-3 {source="NIST Chemistry WebBook"} +xref: CAS:461-72-3 {source="KEGG COMPOUND"} +xref: Gmelin:101266 {source="Gmelin"} +xref: KEGG:C05146 +xref: PDBeChem:HYN +is_a: CHEBI:24628 ! imidazolidine-2,4-dione +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H4N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WJRBRSLFGCUECM-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "100.07614" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "100.02728" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1CNC(=O)N1" xsd:string + +[Term] +id: CHEBI:27656 +name: camptothecin +namespace: chebi_ontology +alt_id: CHEBI:22997 +alt_id: CHEBI:3343 +def: "A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer)." [] +subset: 3_STAR +synonym: "(+)-camptothecin" RELATED [DrugBank] +synonym: "(+)-camptothecine" RELATED [DrugBank] +synonym: "(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-(+)-camptothecin" RELATED [DrugBank] +synonym: "20(S)-camptothecine" RELATED [ChemIDplus] +synonym: "21,22-Secocamptothecin-21-oic acid lactone" RELATED [ChemIDplus] +synonym: "Camptothecin" EXACT [KEGG_COMPOUND] +synonym: "Camptothecine" RELATED [ChemIDplus] +synonym: "CPT" RELATED [DrugBank] +synonym: "D-camptothecin" RELATED [DrugBank] +xref: Beilstein:6075662 {source="Beilstein"} +xref: CAS:7689-03-4 {source="ChemIDplus"} +xref: DrugBank:DB04690 +xref: KEGG:C01897 +xref: KNApSAcK:C00002145 +xref: LINCS:LSM-4611 +xref: PDBeChem:EHD +xref: PMID:11024478 {source="Europe PMC"} +xref: PMID:11549373 {source="Europe PMC"} +xref: PMID:23344961 {source="Europe PMC"} +xref: PMID:23474217 {source="Europe PMC"} +xref: PMID:23676007 {source="Europe PMC"} +xref: PMID:8965250 {source="Europe PMC"} +xref: Reaxys:6075662 {source="Reaxys"} +xref: Wikipedia:Camptothecin +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:26509 ! quinoline alkaloid +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:48626 ! pyranoindolizinoquinoline +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:50276 ! EC 5.99.1.2 (DNA topoisomerase) inhibitor +relationship: has_role CHEBI:50902 ! genotoxin +relationship: has_role CHEBI:76924 ! plant metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H16N2O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VSJKWCGYPAHWDS-FQEVSTJZSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "348.35200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "348.11101" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O" xsd:string + [Term] id: CHEBI:27780 name: detergent @@ -8228,6 +13273,83 @@ xref: KEGG:C01689 is_a: CHEBI:33232 ! application is_a: CHEBI:35195 ! surfactant +[Term] +id: CHEBI:27899 +name: cisplatin +namespace: chebi_ontology +alt_id: CHEBI:23314 +alt_id: CHEBI:3722 +def: "A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups)." [] +subset: 3_STAR +synonym: "(SP-4-2)-diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC] +synonym: "(SP-4-2)-diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC] +synonym: "[PtCl2(NH3)2]" RELATED [KEGG_COMPOUND] +synonym: "Briplatin" RELATED BRAND_NAME [ChemIDplus] +synonym: "CDDP" RELATED [KEGG_COMPOUND] +synonym: "cis-[PtCl2(NH3)2]" RELATED [MolBase] +synonym: "cis-DDP" RELATED [ChemIDplus] +synonym: "cis-diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC] +synonym: "cis-diamminedichloroplatinum" RELATED [ChemIDplus] +synonym: "cis-Diamminedichloroplatinum(II)" RELATED [KEGG_COMPOUND] +synonym: "cis-diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC] +synonym: "cis-diammineplatinum(II) dichloride" RELATED [ChemIDplus] +synonym: "cis-dichlorodiammineplatinum(II)" RELATED [ChemIDplus] +synonym: "cis-platin" RELATED [ChEBI] +synonym: "Cismaplat" RELATED BRAND_NAME [DrugBank] +synonym: "Cisplatin" EXACT [KEGG_COMPOUND] +synonym: "cisplatin" RELATED INN [ChemIDplus] +synonym: "cisplatine" RELATED INN [ChemIDplus] +synonym: "cisplatino" RELATED INN [ChemIDplus] +synonym: "cisplatinum" RELATED INN [ChemIDplus] +synonym: "Lederplatin" RELATED BRAND_NAME [DrugBank] +synonym: "Neoplatin" RELATED BRAND_NAME [DrugBank] +synonym: "Peyrone's chloride" RELATED [ChemIDplus] +synonym: "Peyrone's salt" RELATED [ChEBI] +synonym: "Platamine" RELATED [DrugBank] +synonym: "Platinex" RELATED BRAND_NAME [DrugBank] +synonym: "Platinol" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Randa" RELATED BRAND_NAME [DrugBank] +xref: CAS:15663-27-1 {source="ChemIDplus"} +xref: CAS:15663-27-1 {source="KEGG COMPOUND"} +xref: DrugBank:DB00515 +xref: Gmelin:2519 {source="Gmelin"} +xref: HMDB:HMDB0014656 +xref: KEGG:C06911 +xref: KEGG:D00275 +xref: MetaCyc:CPD0-1392 +xref: MolBase:25 +xref: Patent:DE2318020 +xref: Patent:DE2329485 +xref: PMID:10883661 {source="Europe PMC"} +xref: PMID:12537968 {source="Europe PMC"} +xref: PMID:12831510 {source="Europe PMC"} +xref: PMID:12935404 {source="Europe PMC"} +xref: PMID:16327988 {source="Europe PMC"} +xref: PMID:18472761 {source="Europe PMC"} +xref: PMID:1855275 {source="Europe PMC"} +xref: PMID:23554447 {source="Europe PMC"} +xref: PMID:23604226 {source="Europe PMC"} +xref: PMID:23651576 {source="Europe PMC"} +xref: PMID:28494534 {source="Europe PMC"} +xref: Reaxys:11324567 {source="Reaxys"} +xref: Wikipedia:Cisplatin +is_a: CHEBI:51214 ! diamminedichloroplatinum +relationship: has_role CHEBI:173085 ! ferroptosis inducer +relationship: has_role CHEBI:25435 ! mutagen +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:47868 ! photosensitizing agent +relationship: has_role CHEBI:50684 ! cross-linking reagent +relationship: has_role CHEBI:61015 ! nephrotoxin +relationship: has_role CHEBI:68495 ! apoptosis inducer +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl2H6N2Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H6Cl2N2Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LXZZYRPGZAFOLE-UHFFFAOYSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "300.04452" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "298.95560" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]" xsd:string + [Term] id: CHEBI:27958 name: cocaine @@ -8257,25 +13379,42 @@ synonym: "methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octan synonym: "methyl benzoylecgonine" RELATED [ChemIDplus] synonym: "Neurocaine" RELATED [ChemIDplus] xref: Beilstein:3621912 "Beilstein" +xref: Beilstein:3621912 {source="Beilstein"} xref: Beilstein:5291037 "Beilstein" +xref: Beilstein:5291037 {source="Beilstein"} xref: Beilstein:91034 "Beilstein" +xref: Beilstein:91034 {source="Beilstein"} xref: CAS:50-36-2 "NIST Chemistry WebBook" +xref: CAS:50-36-2 {source="NIST Chemistry WebBook"} +xref: CAS:50-36-2 {source="ChemIDplus"} +xref: CAS:50-36-2 {source="KEGG COMPOUND"} xref: Drug_Central:723 "DrugCentral" +xref: Drug_Central:723 {source="DrugCentral"} xref: DrugBank:DB00907 xref: Gmelin:170209 "Gmelin" +xref: Gmelin:170209 {source="Gmelin"} xref: KEGG:C01416 xref: KEGG:D00110 xref: KNApSAcK:C00002285 xref: MetaCyc:CPD-9776 xref: PDBeChem:COC xref: PMID:11416615 "Europe PMC" +xref: PMID:11416615 {source="Europe PMC"} xref: PMID:11853120 "Europe PMC" +xref: PMID:11853120 {source="Europe PMC"} xref: PMID:14962054 "Europe PMC" +xref: PMID:14962054 {source="Europe PMC"} xref: PMID:17551070 "Europe PMC" +xref: PMID:17551070 {source="Europe PMC"} xref: PMID:19536276 "Europe PMC" +xref: PMID:19536276 {source="Europe PMC"} xref: PMID:21150772 "Europe PMC" +xref: PMID:21150772 {source="Europe PMC"} xref: PMID:25303034 "Europe PMC" +xref: PMID:25303034 {source="Europe PMC"} +xref: Reaxys:5291037 {source="Reaxys"} xref: Reaxys:5291037 "Reaxys" +xref: Reaxys:91034 {source="Reaxys"} xref: Reaxys:91034 "Reaxys" xref: Wikipedia:Cocaine is_a: CHEBI:25248 ! methyl ester @@ -8303,6 +13442,101 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "303.35290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "303.14706" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C" xsd:string +[Term] +id: CHEBI:28001 +name: vancomycin +namespace: chebi_ontology +alt_id: CHEBI:27276 +alt_id: CHEBI:49941 +alt_id: CHEBI:9931 +def: "A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile." [] +subset: 3_STAR +synonym: "(1S,2R,18R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" RELATED [ChEBI] +synonym: "(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):C(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]" RELATED [JCBN] +synonym: "(3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "Vancocin" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "vancomicin" RELATED [ChEBI] +synonym: "vancomicina" RELATED INN [ChemIDplus] +synonym: "VANCOMYCIN" EXACT [PDBeChem] +synonym: "Vancomycin" EXACT [KEGG_COMPOUND] +synonym: "vancomycin" RELATED INN [ChemIDplus] +synonym: "vancomycine" RELATED INN [ChemIDplus] +synonym: "vancomycinum" RELATED INN [ChemIDplus] +xref: Beilstein:3132 {source="Beilstein"} +xref: CAS:1404-90-6 {source="ChemIDplus"} +xref: CAS:1404-90-6 {source="KEGG COMPOUND"} +xref: Drug_Central:2807 {source="DrugCentral"} +xref: DrugBank:DB00512 +xref: KEGG:C06689 +xref: KEGG:D00212 +xref: KNApSAcK:C00016052 +xref: MetaCyc:CPD-12245 +xref: Patent:US3067099 +xref: PDBeChem:VAN +xref: PMID:11028184 {source="Europe PMC"} +xref: PMID:11408222 {source="Europe PMC"} +xref: PMID:11688538 {source="Europe PMC"} +xref: PMID:11864951 {source="Europe PMC"} +xref: PMID:11886013 {source="Europe PMC"} +xref: PMID:11980329 {source="Europe PMC"} +xref: PMID:12019070 {source="Europe PMC"} +xref: PMID:12541895 {source="Europe PMC"} +xref: PMID:12852813 {source="Europe PMC"} +xref: PMID:13370625 {source="Europe PMC"} +xref: PMID:13521912 {source="Europe PMC"} +xref: PMID:14605050 {source="Europe PMC"} +xref: PMID:14702667 {source="Europe PMC"} +xref: PMID:15047516 {source="Europe PMC"} +xref: PMID:15081082 {source="Europe PMC"} +xref: PMID:15465645 {source="Europe PMC"} +xref: PMID:15590714 {source="Europe PMC"} +xref: PMID:15792257 {source="Europe PMC"} +xref: PMID:16183423 {source="Europe PMC"} +xref: PMID:16184232 {source="Europe PMC"} +xref: PMID:16420976 {source="Europe PMC"} +xref: PMID:16596002 {source="Europe PMC"} +xref: PMID:16720708 {source="Europe PMC"} +xref: PMID:17027219 {source="Europe PMC"} +xref: PMID:17184835 {source="Europe PMC"} +xref: PMID:17299012 {source="Europe PMC"} +xref: PMID:17594206 {source="Europe PMC"} +xref: PMID:18030187 {source="Europe PMC"} +xref: PMID:18159039 {source="Europe PMC"} +xref: PMID:18162343 {source="Europe PMC"} +xref: PMID:18260149 {source="Europe PMC"} +xref: PMID:18361944 {source="Europe PMC"} +xref: PMID:18462092 {source="Europe PMC"} +xref: PMID:18582342 {source="Europe PMC"} +xref: PMID:18817166 {source="Europe PMC"} +xref: PMID:18983037 {source="Europe PMC"} +xref: PMID:19107100 {source="Europe PMC"} +xref: PMID:19830166 {source="Europe PMC"} +xref: PMID:20956604 {source="Europe PMC"} +xref: PMID:21109901 {source="Europe PMC"} +xref: PMID:21458937 {source="Europe PMC"} +xref: PMID:21466775 {source="Europe PMC"} +xref: PMID:21664803 {source="Europe PMC"} +xref: PMID:21719238 {source="Europe PMC"} +xref: PMID:21951032 {source="Europe PMC"} +xref: PMID:22011388 {source="Europe PMC"} +xref: PMID:22015328 {source="Europe PMC"} +xref: PMID:22027450 {source="Europe PMC"} +xref: PMID:22124537 {source="Europe PMC"} +xref: Reaxys:3132 {source="Reaxys"} +xref: Wikipedia:Vancomycin +is_a: CHEBI:24396 ! glycopeptide +relationship: has_functional_parent CHEBI:47724 ! vancomycin aglycone +relationship: has_role CHEBI:36047 ! antibacterial drug +relationship: has_role CHEBI:76969 ! bacterial metabolite +relationship: is_conjugate_base_of CHEBI:76842 ! vancomycin(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H75Cl2N9O24" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYPYJXKWCTUITO-LYRMYLQWSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1449.25336" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1447.43020" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C(O)=O)c3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1)c(Cl)c2" xsd:string + [Term] id: CHEBI:28044 name: phenylalanine @@ -8344,6 +13578,99 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18918" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(Cc1ccccc1)C(O)=O" xsd:string +[Term] +id: CHEBI:28077 +name: rifampicin +namespace: chebi_ontology +alt_id: CHEBI:26577 +alt_id: CHEBI:45308 +alt_id: CHEBI:8858 +def: "A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)." [] +subset: 3_STAR +synonym: "(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate" EXACT IUPAC_NAME [IUPAC] +synonym: "3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV" RELATED [ChemIDplus] +synonym: "RFP" RELATED [DrugBank] +synonym: "rifamcin" RELATED [ChEBI] +synonym: "Rifampicin" EXACT [KEGG_COMPOUND] +synonym: "rifampicin" RELATED INN [KEGG_DRUG] +synonym: "rifampicina" RELATED INN [DrugBank] +synonym: "rifampicinum" RELATED INN [DrugBank] +synonym: "Rifampin" RELATED [KEGG_COMPOUND] +xref: Beilstein:5723476 {source="Beilstein"} +xref: CAS:13292-46-1 {source="ChemIDplus"} +xref: CAS:13292-46-1 {source="KEGG COMPOUND"} +xref: DrugBank:DB01045 +xref: HMDB:HMDB0015179 +xref: KEGG:C06688 +xref: KEGG:D00211 +xref: Patent:NL6509961 +xref: Patent:US3342810 +xref: PDBeChem:RFP +xref: PMID:11600355 {source="Europe PMC"} +xref: PMID:14665784 {source="Europe PMC"} +xref: PMID:14670633 {source="Europe PMC"} +xref: PMID:15331348 {source="Europe PMC"} +xref: PMID:15383168 {source="Europe PMC"} +xref: PMID:15705662 {source="Europe PMC"} +xref: PMID:16159084 {source="Europe PMC"} +xref: PMID:16515773 {source="Europe PMC"} +xref: PMID:17828712 {source="Europe PMC"} +xref: PMID:18332862 {source="Europe PMC"} +xref: PMID:19386087 {source="Europe PMC"} +xref: PMID:19458074 {source="Europe PMC"} +xref: PMID:19723399 {source="Europe PMC"} +xref: PMID:24718527 {source="Europe PMC"} +xref: PMID:25720500 {source="Europe PMC"} +xref: PMID:26725427 {source="Europe PMC"} +xref: PMID:26819743 {source="Europe PMC"} +xref: PMID:27082586 {source="Europe PMC"} +xref: PMID:27143080 {source="Europe PMC"} +xref: PMID:27182275 {source="Europe PMC"} +xref: PMID:27242224 {source="Europe PMC"} +xref: PMID:27470132 {source="Europe PMC"} +xref: PMID:27569735 {source="Europe PMC"} +xref: PMID:27617596 {source="Europe PMC"} +xref: PMID:27640793 {source="Europe PMC"} +xref: PMID:27755552 {source="Europe PMC"} +xref: PMID:27795624 {source="Europe PMC"} +xref: PMID:27883163 {source="Europe PMC"} +xref: PMID:27965540 {source="Europe PMC"} +xref: PMID:27993874 {source="Europe PMC"} +xref: PMID:28081169 {source="Europe PMC"} +xref: PMID:28118809 {source="Europe PMC"} +xref: PMID:28181840 {source="Europe PMC"} +xref: PMID:28184157 {source="Europe PMC"} +xref: PMID:28207542 {source="Europe PMC"} +xref: PMID:28262820 {source="Europe PMC"} +xref: Reaxys:5723476 {source="Reaxys"} +xref: Wikipedia:Rifampicin +is_a: CHEBI:26580 ! rifamycins +is_a: CHEBI:38532 ! hydrazone +is_a: CHEBI:46847 ! N-iminopiperazine +is_a: CHEBI:46920 ! N-methylpiperazine +is_a: CHEBI:59779 ! cyclic ketal +is_a: CHEBI:72588 ! semisynthetic derivative +relationship: has_role CHEBI:171664 ! antiamoebic agent +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:33231 ! antitubercular agent +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35816 ! leprostatic drug +relationship: has_role CHEBI:37416 ! EC 2.7.7.6 (RNA polymerase) inhibitor +relationship: has_role CHEBI:48001 ! protein synthesis inhibitor +relationship: has_role CHEBI:48422 ! angiogenesis inhibitor +relationship: has_role CHEBI:59517 ! DNA synthesis inhibitor +relationship: has_role CHEBI:63726 ! neuroprotective agent +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77318 ! pregnane X receptor agonist +relationship: is_tautomer_of CHEBI:71365 ! rifampicin zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H58N4O12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JQXXHWHPUNPDRT-WLSIYKJHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "822.94020" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "822.40512" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\\C=N\\N1CCN(C)CC1)c(O)c4c3C2=O" xsd:string + [Term] id: CHEBI:28087 name: glycogen @@ -8368,6 +13695,85 @@ is_a: CHEBI:24384 ! glycogens relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +[Term] +id: CHEBI:28304 +name: heparin +namespace: chebi_ontology +alt_id: CHEBI:24501 +alt_id: CHEBI:5664 +def: "A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule." [] +subset: 3_STAR +synonym: "Bemiparin" RELATED [ChemIDplus] +synonym: "Bemiparin" RELATED [KEGG_COMPOUND] +synonym: "Certoparin" RELATED [ChemIDplus] +synonym: "Cy 222" RELATED [ChemIDplus] +synonym: "Enoxaparin" RELATED [KEGG_COMPOUND] +synonym: "Fluxum" RELATED [ChemIDplus] +synonym: "Heparin" EXACT [KEGG_COMPOUND] +synonym: "heparin" EXACT [UniProt] +synonym: "heparina" RELATED INN [ChemIDplus] +synonym: "heparine" RELATED INN [ChemIDplus] +synonym: "Heparinic acid" RELATED [ChemIDplus] +synonym: "heparinum" RELATED INN [ChemIDplus] +synonym: "Parnaparin" RELATED [ChemIDplus] +synonym: "Reviparin" RELATED [ChemIDplus] +synonym: "Sandoparin" RELATED [ChemIDplus] +xref: CAS:9005-49-6 {source="KEGG COMPOUND"} +xref: CAS:9005-49-6 {source="ChemIDplus"} +xref: DrugBank:DB01109 +xref: KEGG:C00374 +xref: KEGG:D07510 +xref: PMID:16860191 {source="Europe PMC"} +xref: PMID:18809206 {source="Europe PMC"} +xref: PMID:8713797 {source="Europe PMC"} +xref: Wikipedia:Heparin +is_a: CHEBI:24505 ! heparins +relationship: has_role CHEBI:50249 ! anticoagulant +property_value: http://purl.obolibrary.org/obo/chebi/formula "(C26H40N2O36S5)n" xsd:string + +[Term] +id: CHEBI:28306 +name: semicarbazide +namespace: chebi_ontology +alt_id: CHEBI:26644 +alt_id: CHEBI:9102 +def: "A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine." [] +subset: 3_STAR +synonym: "Aminoharnstoff" RELATED [ChEBI] +synonym: "Aminourea" RELATED [KEGG_COMPOUND] +synonym: "Carbamidsaeurehydrazid" RELATED [ChEBI] +synonym: "Carbamoylhydrazine" RELATED [KEGG_COMPOUND] +synonym: "carbamylhydrazine" RELATED [ChemIDplus] +synonym: "carbazamide" RELATED [ChemIDplus] +synonym: "Hydrazinecarboxamide" RELATED [KEGG_COMPOUND] +synonym: "hydrazinecarboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Semicarbazide" EXACT [KEGG_COMPOUND] +synonym: "Semikarbazid" RELATED [NIST_Chemistry_WebBook] +xref: Beilstein:506319 {source="Beilstein"} +xref: CAS:57-56-7 {source="KEGG COMPOUND"} +xref: CAS:57-56-7 {source="ChemIDplus"} +xref: CAS:57-56-7 {source="NIST Chemistry WebBook"} +xref: Gmelin:100758 {source="Gmelin"} +xref: KEGG:C02077 +xref: MetaCyc:SEMICARBAZIDE +xref: PMID:11958526 {source="Europe PMC"} +xref: PMID:17499072 {source="Europe PMC"} +xref: PMID:23194563 {source="Europe PMC"} +xref: PMID:23683401 {source="Europe PMC"} +xref: Reaxys:506319 {source="Reaxys"} +xref: Wikipedia:Semicarbazide +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:35363 ! carbohydrazide +is_a: CHEBI:47857 ! ureas +is_a: CHEBI:64708 ! one-carbon compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH5N3O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUIOPKIIICUYRZ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "75.07002" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "75.04326" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NNC(N)=O" xsd:string + [Term] id: CHEBI:28358 name: rac-lactic acid @@ -8410,6 +13816,66 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)([C@@H](O)C)O.C(=O)([C@H](O)C)O" xsd:string +[Term] +id: CHEBI:28445 +name: vincristine +namespace: chebi_ontology +alt_id: CHEBI:27289 +alt_id: CHEBI:9987 +def: "A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer." [] +subset: 3_STAR +synonym: "(+)-Vincristine" RELATED [DrugCentral] +synonym: "22-oxo-vincaleukoblastine" RELATED [DrugCentral] +synonym: "22-Oxovincaleukoblastine" RELATED [KEGG_COMPOUND] +synonym: "22-oxovincaleukoblastine" EXACT IUPAC_NAME [IUPAC] +synonym: "leucristine" RELATED [DrugCentral] +synonym: "leurocristine" RELATED [ChemIDplus] +synonym: "oncovin" RELATED [DrugCentral] +synonym: "vincristin" RELATED [DrugCentral] +synonym: "Vincristine" EXACT [KEGG_COMPOUND] +synonym: "vinkristin" RELATED [DrugCentral] +xref: Beilstein:4779289 {source="Beilstein"} +xref: CAS:57-22-7 {source="ChemIDplus"} +xref: CAS:57-22-7 {source="KEGG COMPOUND"} +xref: Drug_Central:2825 {source="DrugCentral"} +xref: DrugBank:DB00541 +xref: HMDB:HMDB0014681 +xref: KEGG:C07204 +xref: KEGG:D08679 +xref: KNApSAcK:C00001783 +xref: MetaCyc:CPD-19894 +xref: PMID:18520608 {source="Europe PMC"} +xref: PMID:30277559 {source="Europe PMC"} +xref: PMID:30429697 {source="Europe PMC"} +xref: PMID:30599272 {source="Europe PMC"} +xref: PMID:30604513 {source="Europe PMC"} +xref: PMID:30657998 {source="Europe PMC"} +xref: PMID:31048222 {source="Europe PMC"} +xref: PMID:31161774 {source="Europe PMC"} +xref: PMID:31214762 {source="Europe PMC"} +xref: PMID:31296986 {source="Europe PMC"} +xref: Wikipedia:Vincristine +is_a: CHEBI:24079 ! formamides +is_a: CHEBI:25248 ! methyl ester +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:27288 ! vinca alkaloid +is_a: CHEBI:38163 ! organic heterotetracyclic compound +is_a: CHEBI:38164 ! organic heteropentacyclic compound +is_a: CHEBI:47622 ! acetate ester +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_parent_hydride CHEBI:27375 ! vincaleukoblastine +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:61951 ! microtubule-destabilising agent +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_base_of CHEBI:143658 ! vincristine(2+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H56N4O10" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OGWKCGZFUXNPDA-XQKSVPLYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "824.95780" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "824.39964" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]1(C[C@@H]2C[N@](CCc3c1[nH]c1ccccc31)C[C@](O)(CC)C2)C(=O)OC" xsd:string + [Term] id: CHEBI:28616 name: carbamic acid @@ -8490,6 +13956,58 @@ alt_id: CHEBI:7511 subset: 1_STAR is_a: CHEBI:25500 ! neopterins +[Term] +id: CHEBI:28680 +name: cytarabine +namespace: chebi_ontology +alt_id: CHEBI:23532 +alt_id: CHEBI:4074 +alt_id: CHEBI:40824 +def: "A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties." [] +subset: 3_STAR +synonym: "1-beta-D-Arabinofuranosylcytosine" RELATED [ChemIDplus] +synonym: "4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone" RELATED [ChemIDplus] +synonym: "4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one" EXACT IUPAC_NAME [IUPAC] +synonym: "ara-C" RELATED [ChEBI] +synonym: "arabinocytosine" RELATED [DrugCentral] +synonym: "Arabinoside C" RELATED [DrugCentral] +synonym: "citarabina" RELATED INN [ChemIDplus] +synonym: "Cytarabine" EXACT [KEGG_COMPOUND] +synonym: "cytarabine" RELATED INN [WHO_MedNet] +synonym: "cytarabine" RELATED INN [ChemIDplus] +synonym: "cytarabinum" RELATED INN [ChemIDplus] +synonym: "Cytosine arabinoside" RELATED [KEGG_COMPOUND] +synonym: "Cytosine-1-beta-D-arabinofuranoside" RELATED [KEGG_COMPOUND] +synonym: "cytosine-beta-D-arabinofuranoside" RELATED [ChEBI] +xref: Beilstein:89175 {source="Beilstein"} +xref: CAS:147-94-4 {source="ChemIDplus"} +xref: CAS:147-94-4 {source="KEGG COMPOUND"} +xref: Drug_Central:770 {source="DrugCentral"} +xref: DrugBank:DB00987 +xref: HMDB:HMDB0015122 +xref: KEGG:C02961 +xref: KEGG:D00168 +xref: LINCS:LSM-5470 +xref: PDBeChem:AR3 +xref: PMID:15492802 {source="Europe PMC"} +xref: Reaxys:89175 {source="Reaxys"} +xref: Wikipedia:Cytarabine +is_a: CHEBI:26440 ! pyrimidine nucleoside +is_a: CHEBI:38315 ! beta-D-arabinoside +is_a: CHEBI:63367 ! monosaccharide derivative +relationship: has_functional_parent CHEBI:16040 ! cytosine +relationship: has_role CHEBI:22587 ! antiviral agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35705 ! immunosuppressive agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13N3O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UHDGCWIWMRVCDJ-CCXZUQQUSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "243.21674" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "243.08552" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1" xsd:string + [Term] id: CHEBI:28694 name: copper atom @@ -8524,6 +14042,52 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "63.54600" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.92960" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Cu]" xsd:string +[Term] +id: CHEBI:28748 +name: doxorubicin +namespace: chebi_ontology +alt_id: CHEBI:22270 +alt_id: CHEBI:2496 +alt_id: CHEBI:42031 +subset: 3_STAR +synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside" EXACT IUPAC_NAME [IUPAC] +synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside" RELATED [ChEBI] +synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione" RELATED [ChemIDplus] +synonym: "14-hydroxydaunomycin" RELATED [ChemIDplus] +synonym: "14-hydroxydaunorubicine" RELATED [ChemIDplus] +synonym: "Adriamycin" RELATED [KEGG_COMPOUND] +synonym: "DOXORUBICIN" EXACT [PDBeChem] +synonym: "Doxorubicin" EXACT [KEGG_COMPOUND] +synonym: "doxorubicin" RELATED INN [ChemIDplus] +synonym: "doxorubicine" RELATED INN [ChemIDplus] +synonym: "doxorubicinum" RELATED INN [ChemIDplus] +xref: CAS:23214-92-8 {source="ChemIDplus"} +xref: CAS:23214-92-8 {source="KEGG COMPOUND"} +xref: Drug_Central:960 {source="DrugCentral"} +xref: DrugBank:DB00997 +xref: KEGG:C01661 +xref: KEGG:D03899 +xref: LINCS:LSM-4062 +xref: LIPID_MAPS_instance:LMPK13050001 {source="LIPID MAPS"} +xref: PDBeChem:DM2 +is_a: CHEBI:139590 ! primary alpha-hydroxy ketone +is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone +is_a: CHEBI:25830 ! p-quinones +is_a: CHEBI:35315 ! deoxy hexoside +is_a: CHEBI:47779 ! aminoglycoside +is_a: CHEBI:49322 ! anthracycline antibiotic +is_a: CHEBI:51286 ! tetracenequinones +relationship: has_parent_hydride CHEBI:32600 ! tetracene +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: is_conjugate_base_of CHEBI:64816 ! doxorubicin(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H29NO11" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AOJJSUZBOXZQNB-TZSSRYMLSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "543.51930" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "543.17406" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO" xsd:string + [Term] id: CHEBI:28790 name: serotonin @@ -8681,6 +14245,71 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string +[Term] +id: CHEBI:28876 +name: melphalan +namespace: chebi_ontology +alt_id: CHEBI:25815 +alt_id: CHEBI:6742 +def: "A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring." [] +subset: 3_STAR +synonym: "3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine" RELATED [ChemIDplus] +synonym: "3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine" RELATED [ChemIDplus] +synonym: "4-(Bis(2-chloroethyl)amino)-L-phenylalanine" RELATED [ChemIDplus] +synonym: "4-[bis(2-chloroethyl)amino]-L-phenylalanine" EXACT IUPAC_NAME [IUPAC] +synonym: "L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine" RELATED [ChemIDplus] +synonym: "L-PAM" RELATED [ChemIDplus] +synonym: "L-Phenylalanine mustard" RELATED [ChemIDplus] +synonym: "L-Sarcolysine" RELATED [ChemIDplus] +synonym: "melfalano" RELATED INN [ChemIDplus] +synonym: "melphalan" RELATED INN [KEGG_DRUG] +synonym: "melphalanum" RELATED INN [ChemIDplus] +synonym: "p-Bis(beta-chloroethyl)aminophenylalanine" RELATED [ChemIDplus] +synonym: "p-Di-(2-chloroethyl)amino-L-phenylalanine" RELATED [ChemIDplus] +synonym: "p-L-Sarcolysin" RELATED [ChemIDplus] +synonym: "p-N,N-bis(2-chloroethyl)amino-L-phenylalanine" RELATED [ChEBI] +synonym: "p-N-Bis(2-chloroethyl)amino-L-phenylalanine" RELATED [ChemIDplus] +synonym: "Phenylalanine mustard" RELATED [ChemIDplus] +synonym: "Phenylalanine nitrogen mustard" RELATED [ChemIDplus] +xref: CAS:148-82-3 {source="KEGG DRUG"} +xref: CAS:148-82-3 {source="ChemIDplus"} +xref: Drug_Central:1678 {source="DrugCentral"} +xref: DrugBank:DB01042 +xref: KEGG:D00369 +xref: Patent:US108552 +xref: Patent:US275057 +xref: Patent:US3032584 +xref: Patent:US3032585 +xref: PMID:10820424 {source="Europe PMC"} +xref: PMID:10937717 {source="Europe PMC"} +xref: PMID:11680815 {source="Europe PMC"} +xref: PMID:11914777 {source="Europe PMC"} +xref: PMID:18481314 {source="Europe PMC"} +xref: PMID:445303 {source="Europe PMC"} +xref: PMID:7494795 {source="Europe PMC"} +xref: PMID:7605343 {source="Europe PMC"} +xref: PMID:8552138 {source="Europe PMC"} +xref: PMID:8951232 {source="Europe PMC"} +xref: PMID:9218926 {source="Europe PMC"} +xref: PMID:9250538 {source="Europe PMC"} +xref: Reaxys:2816456 {source="Reaxys"} +xref: Wikipedia:Melphalan +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:37598 ! nitrogen mustard +is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid +is_a: CHEBI:84144 ! L-phenylalanine derivative +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:50903 ! carcinogenic agent +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H18Cl2N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGDBTWWWUNNDEQ-LBPRGKRZSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "305.20000" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "304.07453" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O" xsd:string + [Term] id: CHEBI:28918 name: (R)-adrenaline @@ -8905,6 +14534,11 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "62.02478" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.00039" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(O)=O" xsd:string +[Term] +id: CHEBI:29057 +name: keratan +is_a: CHEBI:18085 ! glycosaminoglycan + [Term] id: CHEBI:29067 name: carboxylic acid anion @@ -9087,6 +14721,30 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "39.09830" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "38.96316" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[K+]" xsd:string +[Term] +id: CHEBI:29214 +name: sulfonic acid +namespace: chebi_ontology +subset: 3_STAR +synonym: "[SHO2(OH)]" RELATED [IUPAC] +synonym: "acide sulfonique" RELATED [ChEBI] +synonym: "HSHO3" RELATED [IUPAC] +synonym: "hydridohydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC] +synonym: "sulfonic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "Sulfonsaeure" RELATED [ChEBI] +synonym: "sulphonic acid" RELATED [ChEBI] +xref: Gmelin:1404640 {source="Gmelin"} +is_a: CHEBI:33402 ! sulfur oxoacid +relationship: is_conjugate_acid_of CHEBI:33543 ! sulfonate +relationship: is_tautomer_of CHEBI:48854 ! sulfurous acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S(O)(=O)=O" xsd:string + [Term] id: CHEBI:29256 name: thiol @@ -9117,6 +14775,25 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "33.07300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.97990" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "S[*]" xsd:string +[Term] +id: CHEBI:29277 +name: dinitride(2-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "diazenediide" EXACT IUPAC_NAME [IUPAC] +synonym: "dinitride(2-)" EXACT IUPAC_NAME [IUPAC] +synonym: "N2(2-)" RELATED [IUPAC] +xref: Gmelin:1565041 {source="Gmelin"} +is_a: CHEBI:33266 ! diatomic nitrogen +relationship: is_conjugate_base_of CHEBI:30103 ! diazenide +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/N2/c1-2/q-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BZZJUZUZJRQHLZ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01348" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00725" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[N-]=[N-]" xsd:string + [Term] id: CHEBI:29337 name: azanide @@ -9177,6 +14854,27 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])C([*])=O" xsd:string +[Term] +id: CHEBI:29360 +name: methanediide +namespace: chebi_ontology +subset: 3_STAR +synonym: "[CH2](2-)" RELATED [ChEBI] +synonym: "CH2(2-)" RELATED [IUPAC] +synonym: "dihydridocarbonate(2-)" EXACT IUPAC_NAME [IUPAC] +synonym: "methanediide" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:5915711 {source="Beilstein"} +xref: Gmelin:322698 {source="Gmelin"} +is_a: CHEBI:38222 ! hydrocarbyl anion +relationship: is_conjugate_base_of CHEBI:29438 ! methanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2/h1H2/q-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PZPOWPOFQLSNJO-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "14.02658" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.01675" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C--][H]" xsd:string + [Term] id: CHEBI:29412 name: oxonium @@ -9207,6 +14905,46 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "19.02322" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "19.01784" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][O+]([H])[H]" xsd:string +[Term] +id: CHEBI:29438 +name: methanide +namespace: chebi_ontology +subset: 3_STAR +synonym: "[CH3](-)" RELATED [ChEBI] +synonym: "CH3(-)" RELATED [IUPAC] +synonym: "lambda(2)-methanuide" RELATED [IUPAC] +synonym: "methanide" EXACT IUPAC_NAME [IUPAC] +synonym: "methyl anion" RELATED [IUPAC] +synonym: "trihydridocarbonate(1-)" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1813938 {source="Beilstein"} +xref: CAS:15194-58-8 {source="NIST Chemistry WebBook"} +xref: Gmelin:259263 {source="Gmelin"} +is_a: CHEBI:38222 ! hydrocarbyl anion +relationship: is_conjugate_acid_of CHEBI:29360 ! methanediide +relationship: is_conjugate_base_of CHEBI:16183 ! methane +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3/h1H3/q-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LGRLWUINFJPLSH-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "15.03452" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.02402" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C-]([H])[H]" xsd:string + +[Term] +id: CHEBI:29785 +name: nitro group +namespace: chebi_ontology +subset: 3_STAR +synonym: "-NO2" RELATED [IUPAC] +synonym: "nitro" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:33246 ! inorganic group +is_a: CHEBI:51144 ! nitrogen group +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "46.00550" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.99290" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*[N+](=O)[O-]" xsd:string + [Term] id: CHEBI:29793 name: hydridodioxygen(1+) @@ -9228,6 +14966,46 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "33.00674" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.99711" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][O+]=O" xsd:string +[Term] +id: CHEBI:29806 +name: fumarate(2-) +namespace: chebi_ontology +alt_id: CHEBI:14284 +alt_id: CHEBI:24122 +alt_id: CHEBI:42511 +def: "A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2-)" [] +subset: 3_STAR +synonym: "(2E)-but-2-enedioate" EXACT IUPAC_NAME [IUPAC] +synonym: "(2E)-but-2-enedioate" RELATED [ChEBI] +synonym: "(E)-2-butenedioic acid, ion(2-)" RELATED [ChemIDplus] +synonym: "FUMARATE" RELATED [PDBeChem] +synonym: "fumarate" RELATED [UniProt] +xref: Beilstein:1861276 {source="Beilstein"} +xref: CAS:142-42-7 {source="ChemIDplus"} +xref: DrugBank:DB01677 +xref: Gmelin:325288 {source="Gmelin"} +xref: KEGG:C00122 +xref: MetaCyc:FUM +xref: PDBeChem:FUM +xref: PMID:15618158 {source="Europe PMC"} +xref: PMID:16857679 {source="Europe PMC"} +xref: PMID:17190852 {source="Europe PMC"} +xref: PMID:22052553 {source="Europe PMC"} +xref: PMID:22405071 {source="Europe PMC"} +xref: Reaxys:1861276 {source="Reaxys"} +xref: UM-BBD_compID:c0111 {source="UM-BBD"} +is_a: CHEBI:36180 ! butenedioate +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: is_conjugate_base_of CHEBI:37154 ! fumarate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H2O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/p-2/b2-1+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VZCYOOQTPOCHFL-OWOJBTEDSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "114.05628" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "113.99641" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)\\C=C\\C([O-])=O" xsd:string + [Term] id: CHEBI:29917 name: thiol group @@ -9282,6 +15060,25 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "33.07394" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.98044" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S-][H]" xsd:string +[Term] +id: CHEBI:29922 +name: sulfo group +namespace: chebi_ontology +subset: 3_STAR +synonym: "-S(O)2(OH)" RELATED [IUPAC] +synonym: "hydroxydioxo-lambda(6)-sulfanyl" EXACT IUPAC_NAME [IUPAC] +synonym: "hydroxysulfonyl" EXACT IUPAC_NAME [IUPAC] +synonym: "sulfo" EXACT IUPAC_NAME [IUPAC] +synonym: "SULFO GROUP" EXACT [PDBeChem] +xref: PDBeChem:SFO +is_a: CHEBI:33246 ! inorganic group +relationship: is_substituent_group_from CHEBI:29214 ! sulfonic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "S(=O)(O)(*)=O" xsd:string + [Term] id: CHEBI:29985 name: L-glutamate(1-) @@ -9476,6 +15273,27 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "59.04402" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01385" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC([O-])=O" xsd:string +[Term] +id: CHEBI:30096 +name: diazene +namespace: chebi_ontology +subset: 3_STAR +synonym: "diazene" EXACT IUPAC_NAME [IUPAC] +synonym: "Diimide" RELATED [NIST_Chemistry_WebBook] +synonym: "HN=NH" RELATED [IUPAC] +xref: CAS:3618-05-1 {source="NIST Chemistry WebBook"} +xref: CAS:3618-05-1 {source="ChemIDplus"} +xref: KEGG:C05360 +is_a: CHEBI:35106 ! nitrogen hydride +relationship: is_conjugate_acid_of CHEBI:30103 ! diazenide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2N2/c1-2/h1-2H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RAABOESOVLLHRU-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "30.02936" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.02180" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N=N" xsd:string + [Term] id: CHEBI:30099 name: diazynediium @@ -9514,6 +15332,41 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "29.02142" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.01342" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N+]#N" xsd:string +[Term] +id: CHEBI:30103 +name: diazenide +namespace: chebi_ontology +subset: 3_STAR +synonym: "diazenide" EXACT IUPAC_NAME [IUPAC] +synonym: "N=NH(-)" RELATED [IUPAC] +is_a: CHEBI:35106 ! nitrogen hydride +relationship: is_conjugate_acid_of CHEBI:29277 ! dinitride(2-) +relationship: is_conjugate_base_of CHEBI:30096 ! diazene +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HN2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HN2/c1-2/h1H/q-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XSCXGOPPNHTWEF-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "29.02142" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "29.01452" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N=[N-]" xsd:string + +[Term] +id: CHEBI:30106 +name: azo group +namespace: chebi_ontology +subset: 3_STAR +synonym: "-N=N-" RELATED [IUPAC] +synonym: "azo" RELATED [IUPAC] +synonym: "diazene-1,2-diyl" RELATED [IUPAC] +synonym: "diazenediyl" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:33246 ! inorganic group +relationship: is_substituent_group_from CHEBI:30096 ! diazene +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01348" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "28.00615" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(=N/*)\\*" xsd:string + [Term] id: CHEBI:30212 name: photon @@ -9537,6 +15390,18 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "0.0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*" xsd:string +[Term] +id: CHEBI:30217 +name: helium atom +synonym: "2He" RELATED [] +synonym: "He" RELATED [] +synonym: "helio" RELATED [] +synonym: "Helium" RELATED [] +synonym: "helium" EXACT [] +synonym: "helium" RELATED [] +is_a: CHEBI:33309 ! noble gas atom +is_a: CHEBI:33559 ! s-block element atom + [Term] id: CHEBI:30413 name: heme @@ -9590,6 +15455,43 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "35.08982" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.99500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][S+]([H])[H]" xsd:string +[Term] +id: CHEBI:30563 +name: silicon dioxide +namespace: chebi_ontology +def: "A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens." [] +subset: 3_STAR +synonym: "(SiO2)n" RELATED [ChEBI] +synonym: "[SiO2]" RELATED [MolBase] +synonym: "Kieselsaeureanhydrid" RELATED [ChEBI] +synonym: "silica" RELATED [ChEBI] +synonym: "Silica, amorphous" RELATED [KEGG_COMPOUND] +synonym: "silicic anhydride" RELATED [NIST_Chemistry_WebBook] +synonym: "silicon dioxide" EXACT IUPAC_NAME [IUPAC] +synonym: "silicon(IV) oxide" EXACT IUPAC_NAME [IUPAC] +synonym: "Siliziumdioxid" RELATED [ChEBI] +synonym: "SiO2" RELATED [IUPAC] +xref: BPDB:2487 +xref: CAS:7631-86-9 {source="ChemIDplus"} +xref: CAS:7631-86-9 {source="NIST Chemistry WebBook"} +xref: CAS:7631-86-9 {source="KEGG COMPOUND"} +xref: Drug_Central:4284 {source="DrugCentral"} +xref: Gmelin:200274 {source="Gmelin"} +xref: KEGG:C19572 +xref: MolBase:887 +xref: PMID:8991630 {source="Europe PMC"} +xref: PPDB:282 +xref: Reaxys:3902804 {source="Reaxys"} +xref: VSDB:2487 +is_a: CHEBI:33327 ! silicon oxide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "O2Si" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O2Si/c1-3-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VYPSYNLAJGMNEJ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "60.08430" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.96676" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=[Si]=O" xsd:string + [Term] id: CHEBI:305790 name: thyroxine zwitterion @@ -9665,6 +15567,134 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "273.28394" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.10011" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(Cc1ccc(Oc2ccc(O)cc2)cc1)C(O)=O" xsd:string +[Term] +id: CHEBI:30745 +name: phenylacetic acid +namespace: chebi_ontology +alt_id: CHEBI:25977 +alt_id: CHEBI:44686 +alt_id: CHEBI:8085 +def: "A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group." [] +subset: 3_STAR +synonym: "2-PHENYLACETIC ACID" RELATED [PDBeChem] +synonym: "2-Phenylethanoic acid" RELATED [HMDB] +synonym: "alpha-toluic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Benzeneacetic acid" RELATED [KEGG_COMPOUND] +synonym: "benzeneacetic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Benzylformic acid" RELATED [KEGG_COMPOUND] +synonym: "Omega-Phenylacetic acid" RELATED [HMDB] +synonym: "omega-phenylacetic acid" RELATED [HMDB] +synonym: "PA" RELATED [ChEBI] +synonym: "Phenylacetic acid" EXACT [KEGG_COMPOUND] +synonym: "phenylacetic acid" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1099647 {source="Beilstein"} +xref: CAS:103-82-2 {source="KEGG COMPOUND"} +xref: CAS:103-82-2 {source="ChemIDplus"} +xref: CAS:103-82-2 {source="NIST Chemistry WebBook"} +xref: Drug_Central:4624 {source="DrugCentral"} +xref: ECMDB:ECMDB04128 +xref: Gmelin:68976 {source="Gmelin"} +xref: HMDB:HMDB0000209 +xref: KEGG:C07086 +xref: KNApSAcK:C00000750 +xref: MetaCyc:PHENYLACETATE +xref: PDBeChem:PAC +xref: PMID:12147706 {source="Europe PMC"} +xref: PMID:12569987 {source="Europe PMC"} +xref: PMID:15057459 {source="Europe PMC"} +xref: PMID:15506622 {source="Europe PMC"} +xref: PMID:15646820 {source="Europe PMC"} +xref: PMID:17622769 {source="Europe PMC"} +xref: PMID:2083978 {source="Europe PMC"} +xref: PMID:24587751 {source="Europe PMC"} +xref: PMID:24631718 {source="Europe PMC"} +xref: PMID:7544181 {source="Europe PMC"} +xref: PMID:7716788 {source="Europe PMC"} +xref: Reaxys:1099647 {source="Reaxys"} +xref: Wikipedia:Phenylacetic_acid +xref: YMDB:YMDB00891 +is_a: CHEBI:25978 ! phenylacetic acids +relationship: has_functional_parent CHEBI:15366 ! acetic acid +relationship: has_role CHEBI:22676 ! auxin +relationship: has_role CHEBI:27026 ! toxin +relationship: has_role CHEBI:35219 ! plant growth retardant +relationship: has_role CHEBI:50904 ! allergen +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76956 ! Aspergillus metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: has_role CHEBI:90318 ! EC 6.4.1.1 (pyruvate carboxylase) inhibitor +relationship: is_conjugate_acid_of CHEBI:18401 ! phenylacetate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H8O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLJVXDMOQOGPHL-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "136.14792" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "136.05243" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)Cc1ccccc1" xsd:string + +[Term] +id: CHEBI:30746 +name: benzoic acid +namespace: chebi_ontology +alt_id: CHEBI:22722 +alt_id: CHEBI:3029 +alt_id: CHEBI:41051 +def: "A compound comprising a benzene ring core carrying a carboxylic acid substituent." [] +subset: 3_STAR +synonym: "acide benzoique" RELATED [ChEBI] +synonym: "Aromatic carboxylic acid" RELATED [KEGG_COMPOUND] +synonym: "Benzenecarboxylic acid" RELATED [KEGG_COMPOUND] +synonym: "Benzeneformic acid" RELATED [HMDB] +synonym: "Benzenemethanoic acid" RELATED [HMDB] +synonym: "Benzoesaeure" RELATED [ChEBI] +synonym: "BENZOIC ACID" EXACT [PDBeChem] +synonym: "Benzoic acid" EXACT [KEGG_COMPOUND] +synonym: "benzoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "Dracylic acid" RELATED [KEGG_COMPOUND] +synonym: "E210" RELATED [ChEBI] +synonym: "Phenylcarboxylic acid" RELATED [HMDB] +synonym: "Phenylformic acid" RELATED [KEGG_COMPOUND] +xref: Beilstein:636131 {source="Beilstein"} +xref: CAS:65-85-0 {source="KEGG COMPOUND"} +xref: CAS:65-85-0 {source="NIST Chemistry WebBook"} +xref: CAS:65-85-0 {source="ChemIDplus"} +xref: Drug_Central:4664 {source="DrugCentral"} +xref: DrugBank:DB03793 +xref: Gmelin:2946 {source="Gmelin"} +xref: HMDB:HMDB0001870 +xref: KEGG:C00180 +xref: KEGG:C00539 +xref: KEGG:D00038 +xref: KNApSAcK:C00000207 +xref: LINCS:LSM-37118 +xref: MetaCyc:BENZOATE +xref: PDBeChem:BEZ +xref: PMID:16728954 {source="Europe PMC"} +xref: PMID:17439666 {source="Europe PMC"} +xref: PMID:18314336 {source="Europe PMC"} +xref: PPDB:1475 +xref: Reaxys:636131 {source="Reaxys"} +xref: Wikipedia:Benzoic_Acid +xref: YMDB:YMDB02301 +is_a: CHEBI:22723 ! benzoic acids +relationship: has_role CHEBI:64996 ! EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor +relationship: has_role CHEBI:65001 ! EC 3.1.1.3 (triacylglycerol lipase) inhibitor +relationship: has_role CHEBI:65256 ! antimicrobial food preservative +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76967 ! human xenobiotic metabolite +relationship: has_role CHEBI:84735 ! algal metabolite +relationship: has_role CHEBI:88188 ! drug allergen +relationship: is_conjugate_acid_of CHEBI:16150 ! benzoate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WPYMKLBDIGXBTP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "122.12130" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.03678" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1ccccc1" xsd:string + [Term] id: CHEBI:30751 name: formic acid @@ -9741,6 +15771,39 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "46.02538" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(O)=O" xsd:string +[Term] +id: CHEBI:30762 +name: salicylate +namespace: chebi_ontology +alt_id: CHEBI:15061 +alt_id: CHEBI:26595 +def: "A monohydroxybenzoate that is the conjugate base of salicylic acid." [] +subset: 3_STAR +synonym: "2-hydroxybenzoate" EXACT IUPAC_NAME [IUPAC] +synonym: "2-hydroxybenzoic acid ion(1-)" RELATED [ChemIDplus] +synonym: "o-hydroxybenzoate" RELATED [ChemIDplus] +synonym: "sal" RELATED [IUPAC] +synonym: "Salicylate" EXACT [KEGG_COMPOUND] +synonym: "salicylate" EXACT [UniProt] +xref: Beilstein:3605209 {source="Beilstein"} +xref: CAS:63-36-5 {source="ChemIDplus"} +xref: Gmelin:3417 {source="Gmelin"} +xref: KEGG:C00805 +xref: PMID:16669002 {source="Europe PMC"} +xref: PMID:16934829 {source="Europe PMC"} +xref: Reaxys:3605209 {source="Reaxys"} +xref: UM-BBD_compID:c0043 {source="UM-BBD"} +is_a: CHEBI:25388 ! monohydroxybenzoate +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_base_of CHEBI:16914 ! salicylic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H5O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YGSDEFSMJLZEOE-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "137.11280" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "137.02442" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1ccccc1C([O-])=O" xsd:string + [Term] id: CHEBI:30768 name: propionic acid @@ -9932,12 +15995,276 @@ synonym: "alcohols" EXACT IUPAC_NAME [IUPAC] synonym: "an alcohol" RELATED [UniProt] xref: KEGG:C00069 is_a: CHEBI:33822 ! organic hydroxy compound +is_a: FOODON:00001579 ! alcoholic beverage property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "HOR" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "17.007" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O[*]" xsd:string +[Term] +id: CHEBI:3095 +name: biguanide +namespace: chebi_ontology +subset: 3_STAR +synonym: "1,2,3-triimidodicarbonic diamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Biguanide" EXACT [KEGG_COMPOUND] +synonym: "biguanide" EXACT IUPAC_NAME [IUPAC] +synonym: "H2N-C(=NH)-NH-C(=NH)-NH2" RELATED [IUPAC] +synonym: "Hbig" RELATED [IUPAC] +synonym: "imidodicarbonimidic diamide" RELATED [IUPAC] +xref: Beilstein:507183 {source="Beilstein"} +xref: CAS:56-03-1 {source="ChemIDplus"} +xref: CAS:56-03-1 {source="KEGG COMPOUND"} +xref: Gmelin:240093 {source="Gmelin"} +xref: KEGG:C07672 +is_a: CHEBI:24436 ! guanidines +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H7N5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H7N5/c3-1(4)7-2(5)6/h(H7,3,4,5,6,7)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XNCOSPRUTUOJCJ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "101.11068" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.07015" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=N)NC(N)=N" xsd:string + +[Term] +id: CHEBI:3098 +name: bile acid +namespace: chebi_ontology +def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." [] +subset: 3_STAR +synonym: "5beta-bile acid" RELATED [ChEBI] +synonym: "5beta-bile acids" RELATED [ChEBI] +synonym: "Bile acid" EXACT [KEGG_COMPOUND] +synonym: "bile acids" RELATED [ChEBI] +synonym: "Bile salt" RELATED [KEGG_COMPOUND] +synonym: "Gallensaeure" RELATED [ChEBI] +synonym: "Gallensaeuren" RELATED [ChEBI] +xref: KEGG:C01558 +is_a: CHEBI:138366 ! bile acids +is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid + +[Term] +id: CHEBI:31225 +name: antipyrine +namespace: chebi_ontology +def: "A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2." [] +subset: 3_STAR +synonym: "1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one" RELATED [ChemIDplus] +synonym: "1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one" EXACT IUPAC_NAME [IUPAC] +synonym: "2,3-Dimethyl-1-phenyl-5-pyrazolone" RELATED [ChemIDplus] +synonym: "Antipyrine" EXACT [KEGG_COMPOUND] +synonym: "Antipyrine" EXACT [KEGG_DRUG] +synonym: "fenazona" RELATED INN [WHO_MedNet] +synonym: "Phenazone" RELATED [KEGG_COMPOUND] +synonym: "phenazone" RELATED INN [WHO_MedNet] +synonym: "phenazone" RELATED INN [KEGG_DRUG] +synonym: "phenazonum" RELATED INN [WHO_MedNet] +xref: Beilstein:157775 {source="Beilstein"} +xref: CAS:60-80-0 {source="ChemIDplus"} +xref: CAS:60-80-0 {source="KEGG COMPOUND"} +xref: CAS:60-80-0 {source="NIST Chemistry WebBook"} +xref: Drug_Central:861 {source="DrugCentral"} +xref: DrugBank:DB01435 +xref: HMDB:HMDB0015503 +xref: KEGG:C13244 +xref: KEGG:D01776 +xref: LINCS:LSM-3038 +xref: PMID:24345239 {source="Europe PMC"} +xref: PMID:25038548 {source="Europe PMC"} +xref: PMID:25435228 {source="Europe PMC"} +xref: PMID:25631541 {source="Europe PMC"} +xref: PMID:26703262 {source="Europe PMC"} +xref: PMID:3425858 {source="Europe PMC"} +xref: Reaxys:157775 {source="Reaxys"} +xref: Wikipedia:Antipyrine +is_a: CHEBI:83328 ! pyrazolone +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35493 ! antipyretic +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:73263 ! cyclooxygenase 3 inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C11H12N2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C11H12N2O/c1-9-8-11(14)13(12(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VEQOALNAAJBPNY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "188.22580" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "188.09496" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cc(=O)n(-c2ccccc2)n1C" xsd:string + +[Term] +id: CHEBI:31236 +name: aripiprazole +namespace: chebi_ontology +def: "An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders." [] +subset: 3_STAR +synonym: "7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone" RELATED [ChemIDplus] +synonym: "7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one" RELATED [PDBeChem] +synonym: "7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one" RELATED [ChEBI] +synonym: "7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one" EXACT IUPAC_NAME [IUPAC] +synonym: "Abilify" RELATED BRAND_NAME [DrugBank] +synonym: "Abilify Discmelt" RELATED BRAND_NAME [ChemIDplus] +synonym: "Abilify Maintena" RELATED BRAND_NAME [ChemIDplus] +synonym: "Abilify MyCite" RELATED BRAND_NAME [ChemIDplus] +synonym: "Abilitat" RELATED BRAND_NAME [DrugBank] +synonym: "aripiprazol" RELATED INN [WHO_MedNet] +synonym: "aripiprazole" RELATED INN [WHO_MedNet] +synonym: "aripiprazolum" RELATED INN [WHO_MedNet] +synonym: "Arpizol" RELATED BRAND_NAME [DrugCentral] +synonym: "Asprito" RELATED BRAND_NAME [ChEBI] +synonym: "Discmelt" RELATED BRAND_NAME [ChemIDplus] +synonym: "OPC 14597" RELATED [ChemIDplus] +synonym: "OPC 31" RELATED [ChemIDplus] +synonym: "OPC-14597" RELATED [ChemIDplus] +synonym: "OPC-31" RELATED [ChemIDplus] +synonym: "Pripiprazole" RELATED BRAND_NAME [DrugCentral] +xref: CAS:129722-12-9 {source="ChemIDplus"} +xref: CAS:129722-12-9 {source="KEGG COMPOUND"} +xref: Chemspider:54790 +xref: Drug_Central:242 {source="DrugCentral"} +xref: DrugBank:DB01238 +xref: FooDB:FDB004879 +xref: HMDB:HMDB0005042 +xref: KEGG:C12564 +xref: KEGG:D01164 +xref: LINCS:LSM-5776 +xref: Patent:EP367141 +xref: Patent:US5006528 +xref: PDBeChem:9SC +xref: PMID:12063084 {source="Europe PMC"} +xref: PMID:12784105 {source="Europe PMC"} +xref: PMID:14998222 {source="Europe PMC"} +xref: PMID:15019558 {source="Europe PMC"} +xref: PMID:15189766 {source="Europe PMC"} +xref: PMID:15257633 {source="Europe PMC"} +xref: PMID:15825673 {source="Europe PMC"} +xref: PMID:16401666 {source="Europe PMC"} +xref: PMID:16508892 {source="Europe PMC"} +xref: PMID:16554739 {source="Europe PMC"} +xref: PMID:16648324 {source="Europe PMC"} +xref: PMID:16880478 {source="Europe PMC"} +xref: PMID:17115868 {source="Europe PMC"} +xref: PMID:17472545 {source="Europe PMC"} +xref: PMID:17501690 {source="Europe PMC"} +xref: PMID:18021764 {source="Europe PMC"} +xref: PMID:18646161 {source="Europe PMC"} +xref: PMID:18720421 {source="Europe PMC"} +xref: PMID:18765484 {source="Europe PMC"} +xref: PMID:18788833 {source="Europe PMC"} +xref: PMID:19412463 {source="Europe PMC"} +xref: PMID:19956463 {source="Europe PMC"} +xref: PMID:20201815 {source="Europe PMC"} +xref: PMID:30292748 {source="Europe PMC"} +xref: PMID:30411049 {source="Europe PMC"} +xref: PMID:30856161 {source="Europe PMC"} +xref: PMID:31152368 {source="Europe PMC"} +xref: PMID:31320322 {source="Europe PMC"} +xref: PMID:32891516 {source="Europe PMC"} +xref: PMID:33064050 {source="Europe PMC"} +xref: PMID:33347031 {source="Europe PMC"} +xref: Wikipedia:Aripiprazole +is_a: CHEBI:23697 ! dichlorobenzene +is_a: CHEBI:23765 ! quinolone +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:46845 ! N-alkylpiperazine +is_a: CHEBI:46848 ! N-arylpiperazine +is_a: CHEBI:77727 ! delta-lactam +relationship: has_role CHEBI:35941 ! serotonergic agonist +relationship: has_role CHEBI:37955 ! H1-receptor antagonist +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:65191 ! second generation antipsychotic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27Cl2N3O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CEUORZQYGODEFX-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "448.390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "447.14803" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCOC2=CC=C3CCC(=O)NC3=C2)CC1" xsd:string + +[Term] +id: CHEBI:31355 +name: carboplatin +namespace: chebi_ontology +alt_id: CHEBI:76407 +def: "A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand." [] +subset: 3_STAR +synonym: "(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum" EXACT IUPAC_NAME [IUPAC] +synonym: "Carboplatin" EXACT [KEGG_DRUG] +synonym: "carboplatin" RELATED INN [WHO_MedNet] +synonym: "carboplatine" RELATED INN [WHO_MedNet] +synonym: "carboplatino" RELATED INN [WHO_MedNet] +synonym: "carboplatinum" RELATED INN [WHO_MedNet] +synonym: "cbdca" RELATED [ChemIDplus] +synonym: "cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)" RELATED [ChemIDplus] +synonym: "cis-diammine(1,1-cyclobutanedicarboxylato)platinum" RELATED [ChemIDplus] +synonym: "cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)" RELATED [ChemIDplus] +synonym: "Paraplatin" RELATED [ChemIDplus] +xref: CAS:41575-94-4 {source="ChemIDplus"} +xref: CAS:41575-94-4 {source="KEGG DRUG"} +xref: DrugBank:DB00958 +xref: Gmelin:1044703 {source="Gmelin"} +xref: Gmelin:51428 {source="Gmelin"} +xref: HMDB:HMDB0015093 +xref: KEGG:D01363 +xref: LINCS:LSM-4265 +xref: Patent:DE2329485 +xref: PDBeChem:QPT +xref: PMID:11666286 {source="Europe PMC"} +xref: PMID:14568240 {source="Europe PMC"} +xref: PMID:15896850 {source="Europe PMC"} +xref: PMID:16411667 {source="Europe PMC"} +xref: PMID:17180231 {source="Europe PMC"} +xref: PMID:17497898 {source="Europe PMC"} +xref: PMID:17655933 {source="Europe PMC"} +xref: PMID:18336396 {source="Europe PMC"} +xref: PMID:1855275 {source="Europe PMC"} +xref: PMID:19774597 {source="Europe PMC"} +xref: PMID:21629880 {source="Europe PMC"} +xref: PMID:22525758 {source="Europe PMC"} +xref: PMID:23143236 {source="Europe PMC"} +xref: PMID:23275170 {source="Europe PMC"} +xref: PMID:23396873 {source="Europe PMC"} +xref: PMID:24121332 {source="Europe PMC"} +xref: PMID:25195879 {source="Europe PMC"} +xref: PMID:25195881 {source="Europe PMC"} +xref: PMID:26000441 {source="Europe PMC"} +xref: PMID:26239545 {source="Europe PMC"} +xref: PMID:26327386 {source="Europe PMC"} +xref: PMID:26893290 {source="Europe PMC"} +xref: PMID:28511060 {source="Europe PMC"} +xref: PMID:29632935 {source="Europe PMC"} +xref: PMID:31567140 {source="Europe PMC"} +xref: PMID:31930743 {source="Europe PMC"} +xref: PMID:32072678 {source="Europe PMC"} +xref: PMID:32487607 {source="Europe PMC"} +xref: PMID:32579504 {source="Europe PMC"} +xref: PMID:33052033 {source="Europe PMC"} +xref: PMID:33324858 {source="Europe PMC"} +xref: PMID:33542435 {source="Europe PMC"} +xref: PMID:33716231 {source="Europe PMC"} +xref: PMID:33807309 {source="Europe PMC"} +xref: PMID:33814494 {source="Europe PMC"} +xref: PMID:33829940 {source="Europe PMC"} +xref: PMID:33885718 {source="Europe PMC"} +xref: PMID:9654475 {source="Europe PMC"} +xref: Reaxys:11327310 {source="Reaxys"} +xref: Reaxys:11335262 {source="Reaxys"} +xref: Reaxys:15523471 {source="Reaxys"} +xref: Wikipedia:Carboplatin +is_a: CHEBI:33862 ! platinum coordination entity +relationship: has_part CHEBI:35690 ! cyclobutane-1,1-dicarboxylate(2-) +relationship: has_role CHEBI:25435 ! mutagen +relationship: has_role CHEBI:35610 ! antineoplastic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12N2O4Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6O4Pt.2H3N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OLESAACUTLOWQZ-UHFFFAOYSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "371.256" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "371.04450" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N]([H])([H])[Pt]1(OC(=O)C2(CCC2)C(=O)O1)[N]([H])([H])[H]" xsd:string + [Term] id: CHEBI:3165 name: bradykinin @@ -10039,6 +16366,91 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "183.18500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.99901" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1NS(=O)(=O)c2ccccc12" xsd:string +[Term] +id: CHEBI:3219 +name: bupropion +namespace: chebi_ontology +def: "An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring." [] +subset: 3_STAR +synonym: "2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one" EXACT IUPAC_NAME [IUPAC] +synonym: "Bupropion" EXACT [KEGG_COMPOUND] +xref: Beilstein:2101062 {source="ChemIDplus"} +xref: CAS:34841-39-9 {source="KEGG COMPOUND"} +xref: CAS:34911-55-2 {source="ChemIDplus"} +xref: Drug_Central:435 {source="DrugCentral"} +xref: DrugBank:DB01156 +xref: HMDB:HMDB0001510 +xref: KEGG:C06860 +xref: KEGG:D07591 +xref: LINCS:LSM-1267 +xref: MetaCyc:CPD-3481 +xref: PMID:12826985 {source="Europe PMC"} +xref: PMID:15876900 {source="Europe PMC"} +xref: Reaxys:2101062 {source="Reaxys"} +xref: Wikipedia:Bupropion +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:76224 ! aromatic ketone +is_a: CHEBI:83403 ! monochlorobenzenes +relationship: has_role CHEBI:35469 ! antidepressant +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H18ClNO" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNPPWIUOZRMYNY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "239.74086" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "239.10769" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1" xsd:string + +[Term] +id: CHEBI:3223 +name: buspirone +namespace: chebi_ontology +def: "An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position." [] +subset: 3_STAR +synonym: "8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione" RELATED [ChemIDplus] +synonym: "8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "buspirona" RELATED INN [WHO_MedNet] +synonym: "Buspirone" EXACT [KEGG_COMPOUND] +synonym: "buspirone" RELATED INN [WHO_MedNet] +synonym: "buspirone" RELATED INN [ChemIDplus] +synonym: "buspironum" RELATED INN [WHO_MedNet] +xref: Beilstein:964904 {source="Beilstein"} +xref: CAS:36505-84-7 {source="ChemIDplus"} +xref: CAS:36505-84-7 {source="KEGG COMPOUND"} +xref: Drug_Central:437 {source="DrugCentral"} +xref: DrugBank:DB00490 +xref: HMDB:HMDB0014633 +xref: KEGG:C06861 +xref: KEGG:D07593 +xref: LINCS:LSM-4105 +xref: Patent:DE2057845 +xref: Patent:US3717634 +xref: PMID:15876901 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: PMID:26746121 {source="Europe PMC"} +xref: PMID:8638511 {source="Europe PMC"} +xref: Reaxys:964904 {source="Reaxys"} +xref: Wikipedia:Buspirone +is_a: CHEBI:35624 ! azaspiro compound +is_a: CHEBI:38166 ! organic heteropolycyclic compound +is_a: CHEBI:39447 ! pyrimidines +is_a: CHEBI:46845 ! N-alkylpiperazine +is_a: CHEBI:46848 ! N-arylpiperazine +is_a: CHEBI:48589 ! piperidones +relationship: has_role CHEBI:35474 ! anxiolytic drug +relationship: has_role CHEBI:35717 ! sedative +relationship: has_role CHEBI:35941 ! serotonergic agonist +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +relationship: is_conjugate_base_of CHEBI:132102 ! buspirone(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H31N5O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QWCRAEMEVRGPNT-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "385.504" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "385.24778" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1N=C(N=CC1)N2CCN(CC2)CCCCN3C(CC4(CC3=O)CCCC4)=O" xsd:string + [Term] id: CHEBI:32360 name: icosanoate @@ -10072,6 +16484,45 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "311.52250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "311.29555" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCCCCCCC([O-])=O" xsd:string +[Term] +id: CHEBI:32362 +name: heptanoate +namespace: chebi_ontology +def: "A medium-chain fatty acid anion that is the conjugate base of heptanoic acid; shown in myocardial ischaemia/reperfusion studies to increase levels of C4 Kreb's cycle intermediates." [] +subset: 3_STAR +synonym: "(7:0)" RELATED [ChEBI] +synonym: "1-hexanecarboxylate" RELATED [ChEBI] +synonym: "CH3-[CH2]5-COO(-)" RELATED [IUPAC] +synonym: "enanthate" RELATED [ChEBI] +synonym: "enanthylate" RELATED [ChEBI] +synonym: "heptanoate" EXACT [UniProt] +synonym: "heptanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "heptanoic acid, ion(1-)" RELATED [ChemIDplus] +synonym: "heptoate" RELATED [ChEBI] +synonym: "heptylate" RELATED [ChEBI] +synonym: "n-heptanoate" RELATED [ChEBI] +synonym: "n-heptoate" RELATED [ChEBI] +synonym: "n-heptylate" RELATED [ChEBI] +synonym: "oenanthate" RELATED [ChEBI] +synonym: "oenanthylate" RELATED [ChEBI] +xref: Beilstein:3903940 {source="Beilstein"} +xref: CAS:7563-37-3 {source="ChemIDplus"} +xref: Gmelin:327115 {source="Gmelin"} +xref: MetaCyc:CPD-7619 +xref: PMID:16141384 {source="Europe PMC"} +xref: Reaxys:3903940 {source="Reaxys"} +is_a: CHEBI:58954 ! straight-chain saturated fatty acid anion +is_a: CHEBI:59558 ! medium-chain fatty acid anion +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_base_of CHEBI:45571 ! heptanoic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H13O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H14O2/c1-2-3-4-5-6-7(8)9/h2-6H2,1H3,(H,8,9)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MNWFXJYAOYHMED-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "129.17692" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "129.09210" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCC([O-])=O" xsd:string + [Term] id: CHEBI:32442 name: L-cysteinate(1-) @@ -10295,6 +16746,100 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "122.16716" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "122.02703" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CS)C(O)=O" xsd:string +[Term] +id: CHEBI:32486 +name: L-phenylalaninate +namespace: chebi_ontology +def: "An optically active form of phenylalaninate having L-configuration." [] +subset: 3_STAR +synonym: "(2S)-2-amino-3-phenylpropanoate" RELATED [IUPAC] +synonym: "L-phenylalaninate" EXACT IUPAC_NAME [IUPAC] +synonym: "L-phenylalanine anion" RELATED [JCBN] +xref: Beilstein:4136718 {source="Beilstein"} +xref: Gmelin:329084 {source="Gmelin"} +xref: PMID:21956539 {source="Europe PMC"} +xref: Reaxys:4136718 {source="Reaxys"} +is_a: CHEBI:32504 ! phenylalaninate +is_a: CHEBI:59814 ! L-alpha-amino acid anion +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: is_conjugate_base_of CHEBI:17295 ! L-phenylalanine +relationship: is_enantiomer_of CHEBI:32494 ! D-phenylalaninate +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1/t8-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "164.18120" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.07170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@@H](Cc1ccccc1)C([O-])=O" xsd:string + +[Term] +id: CHEBI:32487 +name: L-phenylalaninium +namespace: chebi_ontology +def: "An optically active form of phenylalaninium having L-configuration." [] +subset: 3_STAR +synonym: "(1S)-1-carboxy-2-phenylethanaminium" RELATED [IUPAC] +synonym: "L-phenylalanine cation" RELATED [JCBN] +synonym: "L-phenylalaninium" EXACT IUPAC_NAME [IUPAC] +xref: PMID:21956539 {source="Europe PMC"} +is_a: CHEBI:32505 ! phenylalaninium +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: is_conjugate_acid_of CHEBI:17295 ! L-phenylalanine +relationship: is_enantiomer_of CHEBI:32495 ! D-phenylalaninium +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1/t8-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "166.19710" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.08626" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H](Cc1ccccc1)C(O)=O" xsd:string + +[Term] +id: CHEBI:32494 +name: D-phenylalaninate +namespace: chebi_ontology +def: "The D-enantiomer of phenylalaninate." [] +subset: 3_STAR +synonym: "(2R)-2-amino-3-phenylpropanoate" RELATED [IUPAC] +synonym: "D-phenylalaninate" EXACT IUPAC_NAME [IUPAC] +synonym: "D-phenylalanine anion" RELATED [JCBN] +xref: Beilstein:5740552 {source="Beilstein"} +xref: Gmelin:746993 {source="Gmelin"} +is_a: CHEBI:32504 ! phenylalaninate +relationship: is_conjugate_base_of CHEBI:16998 ! D-phenylalanine +relationship: is_enantiomer_of CHEBI:32486 ! L-phenylalaninate +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H10NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p-1/t8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "164.18120" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "164.07170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[C@H](Cc1ccccc1)C([O-])=O" xsd:string + +[Term] +id: CHEBI:32495 +name: D-phenylalaninium +namespace: chebi_ontology +def: "An optically active form of phenylalaninium having D-configuration." [] +subset: 3_STAR +synonym: "(1R)-1-carboxy-2-phenylethanaminium" RELATED [IUPAC] +synonym: "D-phenylalanine cation" RELATED [JCBN] +synonym: "D-phenylalaninium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:32505 ! phenylalaninium +relationship: is_conjugate_acid_of CHEBI:16998 ! D-phenylalanine +relationship: is_enantiomer_of CHEBI:32487 ! L-phenylalaninium +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H12NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/p+1/t8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "166.19710" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.08626" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H](Cc1ccccc1)C(O)=O" xsd:string + [Term] id: CHEBI:32504 name: phenylalaninate @@ -10384,6 +16929,34 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02475" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCC([O-])=O" xsd:string +[Term] +id: CHEBI:32600 +name: tetracene +namespace: chebi_ontology +def: "An acene that consists of four ortho-fused benzene rings in a rectilinear arrangement." [] +subset: 3_STAR +synonym: "2,3-benzanthracene" RELATED [NIST_Chemistry_WebBook] +synonym: "benz[b]anthracene" RELATED [NIST_Chemistry_WebBook] +synonym: "naphthacene" RELATED [IUPAC] +synonym: "tetracene" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1909299 {source="Beilstein"} +xref: CAS:92-24-0 {source="NIST Chemistry WebBook"} +xref: CAS:92-24-0 {source="ChemIDplus"} +xref: Gmelin:306993 {source="Gmelin"} +xref: PMID:11493061 {source="Europe PMC"} +xref: PMID:24655187 {source="Europe PMC"} +xref: Reaxys:1909299 {source="Reaxys"} +xref: Wikipedia:Tetracene +is_a: CHEBI:35297 ! acene +is_a: CHEBI:51270 ! tetracenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H12/c1-2-6-14-10-18-12-16-8-4-3-7-15(16)11-17(18)9-13(14)5-1/h1-12H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IFLREYGFSNHWGE-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "228.28788" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "228.09390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2cc3cc4ccccc4cc3cc2c1" xsd:string + [Term] id: CHEBI:32784 name: tyrosinate(1-) @@ -10446,6 +17019,28 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "182.19652" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.08117" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(Cc1ccc(O)cc1)C(O)=O" xsd:string +[Term] +id: CHEBI:32863 +name: secondary amine +namespace: chebi_ontology +alt_id: CHEBI:26618 +alt_id: CHEBI:9078 +def: "A compound formally derived from ammonia by replacing two hydrogen atoms by hydrocarbyl groups." [] +subset: 3_STAR +synonym: "R2NH" RELATED [IUPAC] +synonym: "Secondary amine" EXACT [KEGG_COMPOUND] +synonym: "secondary amines" EXACT IUPAC_NAME [IUPAC] +synonym: "sekundaeres Amin" RELATED [ChEBI] +xref: KEGG:C02324 +is_a: CHEBI:32952 ! amine +is_a: CHEBI:50995 ! secondary amino compound +relationship: is_conjugate_base_of CHEBI:137419 ! secondary ammonium ion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HNR2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "15.01460" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01090" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N([*])[*]" xsd:string + [Term] id: CHEBI:32871 name: prolinate @@ -10489,6 +17084,88 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "116.13840" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.07060" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1CCC[NH2+]1" xsd:string +[Term] +id: CHEBI:32876 +name: tertiary amine +namespace: chebi_ontology +alt_id: CHEBI:26879 +alt_id: CHEBI:9458 +def: "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." [] +subset: 3_STAR +synonym: "R3N" RELATED [IUPAC] +synonym: "tertiaeres Amin" RELATED [ChEBI] +synonym: "Tertiary amine" EXACT [KEGG_COMPOUND] +synonym: "tertiary amines" EXACT IUPAC_NAME [IUPAC] +xref: KEGG:C02196 +is_a: CHEBI:32952 ! amine +is_a: CHEBI:50996 ! tertiary amino compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "NR3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "14.00670" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N([*])[*]" xsd:string + +[Term] +id: CHEBI:32877 +name: primary amine +namespace: chebi_ontology +alt_id: CHEBI:26263 +alt_id: CHEBI:26265 +alt_id: CHEBI:8407 +alt_id: CHEBI:8409 +def: "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." [] +subset: 3_STAR +synonym: "primaeres Amin" RELATED [ChEBI] +synonym: "Primary amine" EXACT [KEGG_COMPOUND] +synonym: "primary amines" EXACT IUPAC_NAME [IUPAC] +synonym: "Primary monoamine" RELATED [KEGG_COMPOUND] +synonym: "R-NH2" RELATED [IUPAC] +synonym: "RCH2NH2" RELATED [KEGG_COMPOUND] +xref: KEGG:C00375 +xref: KEGG:C00893 +xref: KEGG:C02580 +is_a: CHEBI:32952 ! amine +is_a: CHEBI:50994 ! primary amino compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "16.02260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N[*]" xsd:string + +[Term] +id: CHEBI:32898 +name: baccatin III +namespace: chebi_ontology +alt_id: CHEBI:13870 +alt_id: CHEBI:29546 +def: "A tetracyclic diterpenoid isolated from plant species of the genus Taxus." [] +subset: 3_STAR +synonym: "5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate" EXACT IUPAC_NAME [IUPAC] +synonym: "[2aR-(2aalpha,4beta,4abeta,6beta,9alpha,11alpha,12alpha,12aalpha,12balpha)]-6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one" RELATED [ChemIDplus] +synonym: "Baccatin III" EXACT [KEGG_COMPOUND] +synonym: "baccatin III" EXACT [UniProt] +xref: Beilstein:1445625 {source="Beilstein"} +xref: CAS:27548-93-2 {source="ChemIDplus"} +xref: CAS:27548-93-2 {source="KEGG COMPOUND"} +xref: KEGG:C11900 +xref: PMID:23265441 {source="Europe PMC"} +xref: PMID:24403190 {source="Europe PMC"} +xref: PMID:24696551 {source="Europe PMC"} +xref: Reaxys:1445625 {source="Reaxys"} +xref: Wikipedia:Baccatin_III +is_a: CHEBI:36054 ! benzoate ester +is_a: CHEBI:47622 ! acetate ester +is_a: CHEBI:52557 ! tetracyclic diterpenoid +relationship: has_parent_hydride CHEBI:36064 ! taxane +relationship: has_role CHEBI:76924 ! plant metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C31H38O11" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OVMSOCFBDVBLFW-VHLOTGQHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "586.62682" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "586.24141" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](O)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C" xsd:string + [Term] id: CHEBI:32952 name: amine @@ -10505,6 +17182,32 @@ synonym: "Substituted amine" RELATED [KEGG_COMPOUND] xref: KEGG:C00706 is_a: CHEBI:50047 ! organic amino compound +[Term] +id: CHEBI:32955 +name: epoxide +namespace: chebi_ontology +alt_id: CHEBI:13828 +alt_id: CHEBI:23930 +alt_id: CHEBI:4812 +def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." [] +subset: 3_STAR +synonym: "Alkene oxide" RELATED [KEGG_COMPOUND] +synonym: "an epoxide" RELATED [UniProt] +synonym: "Epoxide" EXACT [KEGG_COMPOUND] +synonym: "epoxides" EXACT IUPAC_NAME [IUPAC] +synonym: "epoxides" RELATED [ChEBI] +synonym: "Olefin oxide" RELATED [KEGG_COMPOUND] +xref: KEGG:C00722 +xref: PMID:10891060 {source="Europe PMC"} +xref: Wikipedia:Epoxide +is_a: CHEBI:37407 ! cyclic ether +relationship: has_parent_hydride CHEBI:27561 ! oxirane +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2OR4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "40.02080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "39.99491" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C1([*])OC1([*])[*]" xsd:string + [Term] id: CHEBI:32988 name: amide @@ -10518,6 +17221,17 @@ synonym: "amides" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C00241 is_a: CHEBI:51143 ! nitrogen molecular entity +[Term] +id: CHEBI:33145 +name: boron oxoacid +namespace: chebi_ontology +subset: 3_STAR +synonym: "boron oxoacid" EXACT [ChEBI] +synonym: "boron oxoacids" RELATED [ChEBI] +synonym: "oxoacids of boron" RELATED [ChEBI] +is_a: CHEBI:22916 ! boron molecular entity +is_a: CHEBI:24833 ! oxoacid + [Term] id: CHEBI:33224 name: chromane @@ -10545,12 +17259,14 @@ property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1COc2ccccc2C1" xsd [Term] id: CHEBI:33229 +name: vitamin name: vitamin (role) namespace: chebi_ontology alt_id: CHEBI:10004 alt_id: CHEBI:27305 def: "A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term \"vitamines\" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines." [] subset: 3_STAR +synonym: "Vitamin" EXACT [] synonym: "vitamin" RELATED [ChEBI] synonym: "vitamina" RELATED [ChEBI] synonym: "vitaminas" RELATED [ChEBI] @@ -10562,6 +17278,19 @@ xref: Wikipedia:Vitamin is_a: CHEBI:27027 ! micronutrient is_a: CHEBI:52206 ! biochemical role +[Term] +id: CHEBI:33231 +name: antitubercular agent +namespace: chebi_ontology +def: "A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis." [] +subset: 3_STAR +synonym: "antitubercular" RELATED [ChEBI] +synonym: "antitubercular agents" RELATED [ChEBI] +synonym: "antitubercular drug" RELATED [ChEBI] +synonym: "antitubercular drugs" RELATED [ChEBI] +synonym: "tuberculostatic agent" RELATED [ChEBI] +is_a: CHEBI:64912 ! antimycobacterial drug + [Term] id: CHEBI:33232 name: application @@ -10770,6 +17499,7 @@ synonym: "homoatomic entity" RELATED [ChEBI] synonym: "homoatomic molecular entities" RELATED [ChEBI] synonym: "homoatomic molecular entity" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity +is_a: CHEBI:46662 ! mineral [Term] id: CHEBI:33261 @@ -10927,10 +17657,21 @@ synonym: "fertiliser" RELATED [ChEBI] synonym: "fertilizers" RELATED [ChEBI] is_a: CHEBI:33286 ! agrochemical +[Term] +id: CHEBI:33288 +name: rodenticide +namespace: chebi_ontology +def: "A substance used to destroy rodent pests." [] +subset: 3_STAR +synonym: "rodenticides" RELATED [ChEBI] +xref: Wikipedia:Rodenticide +is_a: CHEBI:25944 ! pesticide + [Term] id: CHEBI:33290 name: food namespace: chebi_ontology +def: "A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life." [] def: "Any material that can be ingested by an organism." [] subset: 3_STAR synonym: "food material" RELATED [ChEBI] @@ -10941,6 +17682,7 @@ synonym: "foodstuff" RELATED [ChEBI] synonym: "foodstuffs" RELATED [ChEBI] is_a: CHEBI:52211 ! physiological role relationship: has_part CHEBI:78295 ! food component +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33292 @@ -11079,6 +17821,38 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)O[*]" xsd:string +[Term] +id: CHEBI:33309 +name: noble gas atom +synonym: "Edelgas" RELATED [] +synonym: "Edelgase" RELATED [] +synonym: "gas noble" RELATED [] +synonym: "gases nobles" RELATED [] +synonym: "gaz noble" RELATED [] +synonym: "gaz nobles" RELATED [] +synonym: "group 18 elements" RELATED [] +synonym: "group VIII elements" RELATED [] +synonym: "inert gases" RELATED [] +synonym: "noble gas" EXACT [] +synonym: "noble gas" RELATED [] +synonym: "noble gases" EXACT [] +synonym: "rare gases" RELATED [] +is_a: CHEBI:138675 ! gas molecular entity +is_a: CHEBI:25585 ! nonmetal atom +is_a: CHEBI:33318 ! main group element atom + +[Term] +id: CHEBI:33317 +name: boron group element atom +namespace: chebi_ontology +subset: 3_STAR +synonym: "boron group element" RELATED [ChEBI] +synonym: "boron group elements" RELATED [ChEBI] +synonym: "Element der Borgruppe" RELATED [ChEBI] +synonym: "group 13 elements" EXACT IUPAC_NAME [IUPAC] +synonym: "group III elements" RELATED [ChEBI] +is_a: CHEBI:33560 ! p-block element atom + [Term] id: CHEBI:33318 name: main group element atom @@ -11091,6 +17865,16 @@ synonym: "main group element" RELATED [ChEBI] synonym: "main group elements" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33250 ! atom +[Term] +id: CHEBI:33327 +name: silicon oxide +namespace: chebi_ontology +subset: 3_STAR +synonym: "oxides of silicon" RELATED [ChEBI] +synonym: "silicon oxides" RELATED [ChEBI] +is_a: CHEBI:24836 ! inorganic oxide +is_a: CHEBI:26677 ! silicon molecular entity + [Term] id: CHEBI:33356 name: iron group element atom @@ -11101,6 +17885,54 @@ synonym: "iron group element" RELATED [ChEBI] synonym: "iron group elements" RELATED [ChEBI] is_a: CHEBI:33561 ! d-block element atom +[Term] +id: CHEBI:33362 +name: nickel group element atom +namespace: chebi_ontology +subset: 3_STAR +synonym: "group 10 elements" EXACT IUPAC_NAME [IUPAC] +synonym: "nickel group element" RELATED [ChEBI] +synonym: "nickel group elements" RELATED [ChEBI] +is_a: CHEBI:33561 ! d-block element atom + +[Term] +id: CHEBI:33364 +name: platinum +namespace: chebi_ontology +subset: 3_STAR +synonym: "78Pt" RELATED [IUPAC] +synonym: "Platin" RELATED [ChEBI] +synonym: "platine" RELATED [ChEBI] +synonym: "platino" RELATED [ChEBI] +synonym: "platinum" EXACT IUPAC_NAME [IUPAC] +synonym: "Pt" RELATED [IUPAC] +xref: CAS:7440-06-4 {source="NIST Chemistry WebBook"} +xref: CAS:7440-06-4 {source="ChemIDplus"} +xref: WebElements:Pt +is_a: CHEBI:33362 ! nickel group element atom +is_a: CHEBI:33365 ! platinum group metal atom +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BASFCYQUMIYNBI-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "195.078" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "194.96479" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Pt]" xsd:string + +[Term] +id: CHEBI:33365 +name: platinum group metal atom +namespace: chebi_ontology +subset: 3_STAR +synonym: "PGM" RELATED [ChEBI] +synonym: "Platinmetalle" RELATED [ChEBI] +synonym: "platinoid" RELATED [ChEBI] +synonym: "Platinoide" RELATED [ChEBI] +synonym: "platinum group metal" RELATED [ChEBI] +synonym: "platinum group metals" RELATED [ChEBI] +synonym: "platinum metals" RELATED [ChEBI] +is_a: CHEBI:27081 ! transition element atom + [Term] id: CHEBI:33366 name: copper group element atom @@ -11261,6 +18093,47 @@ is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33259 ! elemental molecular entity is_a: CHEBI:33302 ! pnictogen molecular entity +[Term] +id: CHEBI:3347 +name: candesartan +namespace: chebi_ontology +def: "A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension." [] +subset: 3_STAR +synonym: "2-ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid" RELATED [ChemIDplus] +synonym: "2-ethoxy-1-({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl)-1H-benzimidazole-7-carboxylic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid" RELATED [IUPAC] +synonym: "2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4ethyl]}-1H-benzimidazole-7-carboxylic acid" RELATED [IUPHAR] +synonym: "Blopress" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "CV-11974" RELATED [ChemIDplus] +xref: Beilstein:6377719 {source="Beilstein"} +xref: CAS:139481-59-7 {source="ChemIDplus"} +xref: CAS:139481-59-7 {source="KEGG COMPOUND"} +xref: DrugBank:DB00796 +xref: HMDB:HMDB0014934 +xref: KEGG:C07468 +xref: KEGG:D00522 +xref: LINCS:LSM-5903 +xref: Patent:EP459136 +xref: Patent:US5196444 +xref: PMID:23713902 {source="Europe PMC"} +xref: PMID:24464858 {source="Europe PMC"} +xref: Reaxys:6377719 {source="Reaxys"} +xref: Wikipedia:Candesartan +is_a: CHEBI:35688 ! benzimidazolecarboxylic acid +is_a: CHEBI:48420 ! biphenylyltetrazole +relationship: has_role CHEBI:35674 ! antihypertensive agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:61016 ! angiotensin receptor antagonist +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_acid_of CHEBI:149509 ! candesartan(2-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H20N6O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HTQMVQVXFRQIKW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "440.45424" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "440.15969" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1" xsd:string + [Term] id: CHEBI:33482 name: sulfur oxoanion @@ -11349,6 +18222,76 @@ synonym: "sulphur hydrides" RELATED [ChEBI] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36902 ! chalcogen hydride +[Term] +id: CHEBI:33543 +name: sulfonate +namespace: chebi_ontology +def: "The sulfur oxoanion formed by deprotonation of sulfonic acid." [] +subset: 3_STAR +synonym: "[SHO3](-)" RELATED [IUPAC] +synonym: "hydridotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC] +synonym: "SHO3(-)" RELATED [IUPAC] +synonym: "sulfonates" RELATED [ChEBI] +xref: Gmelin:971569 {source="Gmelin"} +is_a: CHEBI:33482 ! sulfur oxoanion +relationship: is_conjugate_base_of CHEBI:29214 ! sulfonic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h4H,(H,1,2,3)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BDHFUVZGWQCTTF-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07214" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96519" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]S([O-])(=O)=O" xsd:string + +[Term] +id: CHEBI:33551 +name: organosulfonic acid +namespace: chebi_ontology +def: "An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon." [] +subset: 3_STAR +synonym: "organosulfonic acids" RELATED [ChEBI] +synonym: "sulfonic acids" RELATED [ChEBI] +is_a: CHEBI:33261 ! organosulfur compound +is_a: CHEBI:33552 ! sulfonic acid derivative +is_a: CHEBI:64709 ! organic acid +relationship: has_part CHEBI:29922 ! sulfo group +relationship: has_part CHEBI:33249 ! organyl group +relationship: is_conjugate_acid_of CHEBI:33554 ! organosulfonate oxoanion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HO3SR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "81.07100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "80.96464" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS([*])(=O)=O" xsd:string + +[Term] +id: CHEBI:33552 +name: sulfonic acid derivative +namespace: chebi_ontology +subset: 3_STAR +synonym: "derivatives of sulfonic acid" RELATED [ChEBI] +synonym: "sulfonic acid derivative" EXACT [ChEBI] +synonym: "sulfonic acid derivatives" RELATED [ChEBI] +is_a: CHEBI:33424 ! sulfur oxoacid derivative +relationship: has_functional_parent CHEBI:29214 ! sulfonic acid + +[Term] +id: CHEBI:33554 +name: organosulfonate oxoanion +namespace: chebi_ontology +def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." [] +subset: 3_STAR +synonym: "organosulfonate" RELATED [ChEBI] +synonym: "organosulfonate oxoanions" RELATED [ChEBI] +synonym: "organosulfonates" RELATED [ChEBI] +is_a: CHEBI:25696 ! organic anion +relationship: has_functional_parent CHEBI:33543 ! sulfonate +relationship: is_conjugate_base_of CHEBI:33551 ! organosulfonic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "O3SR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "80.064" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "79.95681" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*S([O-])(=O)=O" xsd:string + [Term] id: CHEBI:33558 name: alpha-amino-acid anion @@ -11588,6 +18531,15 @@ synonym: "main group molecular entities" RELATED [ChEBI] is_a: CHEBI:23367 ! molecular entity relationship: has_part CHEBI:33318 ! main group element atom +[Term] +id: CHEBI:33581 +name: boron group molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "boron group molecular entities" RELATED [ChEBI] +is_a: CHEBI:33675 ! p-block molecular entity +relationship: has_part CHEBI:33317 ! boron group element atom + [Term] id: CHEBI:33582 name: carbon group molecular entity @@ -11598,6 +18550,16 @@ synonym: "carbon group molecular entity" EXACT [ChEBI] is_a: CHEBI:33675 ! p-block molecular entity relationship: has_part CHEBI:33306 ! carbon group element atom +[Term] +id: CHEBI:33583 +name: noble gas molecular entity +def: "A main group molecular entity containing one or more atoms of any noble gas." [] +synonym: "noble gas compounds" RELATED [] +synonym: "noble gas molecular entities" RELATED [] +synonym: "noble gas molecular entity" EXACT [] +is_a: CHEBI:33579 ! main group molecular entity +relationship: has_part CHEBI:33309 ! noble gas atom + [Term] id: CHEBI:33595 name: cyclic compound @@ -11631,6 +18593,22 @@ synonym: "carbocyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33832 ! organic cyclic compound +[Term] +id: CHEBI:33599 +name: spiro compound +namespace: chebi_ontology +def: "A compound having one atom as the only common member of two rings." [] +subset: 3_STAR +synonym: "spiro compound" EXACT IUPAC_NAME [IUPAC] +synonym: "spiro compounds" EXACT IUPAC_NAME [IUPAC] +synonym: "spiro-fused compounds" RELATED [IUPAC] +synonym: "spirocycle" RELATED [ChEBI] +synonym: "spirocycles" RELATED [ChEBI] +synonym: "spirocyclic compound" RELATED [ChEBI] +synonym: "spirocyclic compounds" RELATED [ChEBI] +synonym: "spirofused compounds" RELATED [ChEBI] +is_a: CHEBI:33635 ! polycyclic compound + [Term] id: CHEBI:33608 name: hydrogen molecular entity @@ -11668,6 +18646,15 @@ synonym: "ortho-fused compounds" RELATED [ChEBI] synonym: "ortho-fused polycyclic compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:35293 ! fused compound +[Term] +id: CHEBI:33653 +name: aliphatic compound +namespace: chebi_ontology +def: "Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds." [] +subset: 3_STAR +synonym: "aliphatic compounds" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:50860 ! organic molecular entity + [Term] id: CHEBI:33655 name: aromatic compound @@ -11739,6 +18726,16 @@ synonym: "monocyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC] synonym: "monocyclic hydrocarbons" RELATED [ChEBI] is_a: CHEBI:33663 ! cyclic hydrocarbon +[Term] +id: CHEBI:33666 +name: polycyclic hydrocarbon +namespace: chebi_ontology +subset: 3_STAR +synonym: "polycyclic hydrocarbon" EXACT IUPAC_NAME [IUPAC] +synonym: "polycyclic hydrocarbons" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:33663 ! cyclic hydrocarbon +is_a: CHEBI:35294 ! carbopolycyclic compound + [Term] id: CHEBI:33670 name: heteromonocyclic compound @@ -11806,6 +18803,16 @@ synonym: "d-block molecular entity" EXACT [ChEBI] is_a: CHEBI:33497 ! transition element molecular entity relationship: has_part CHEBI:33561 ! d-block element atom +[Term] +id: CHEBI:33679 +name: helium molecular entity +synonym: "helium compounds" RELATED [] +synonym: "helium molecular entities" RELATED [] +synonym: "helium molecular entity" EXACT [] +is_a: CHEBI:33583 ! noble gas molecular entity +is_a: CHEBI:33674 ! s-block molecular entity +relationship: has_part CHEBI:30217 ! helium atom + [Term] id: CHEBI:33692 name: hydrides @@ -11881,6 +18888,7 @@ synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC] synonym: "ribonucleic acids" RELATED [ChEBI] synonym: "Ribonukleinsaeure" RELATED [ChEBI] synonym: "ribose nucleic acid" RELATED [ChEBI] +synonym: "RNA" RELATED [UniProt] synonym: "RNA" RELATED [IUPAC] synonym: "RNS" RELATED [ChEBI] synonym: "yeast nucleic acid" RELATED [ChEBI] @@ -11949,6 +18957,16 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([*])C(O)=O" xsd:string +[Term] +id: CHEBI:33706 +name: beta-amino acid +namespace: chebi_ontology +def: "A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position beta to the carboxy group." [] +subset: 3_STAR +synonym: "beta-amino acid" EXACT [ChEBI] +synonym: "beta-amino acids" RELATED [ChEBI] +is_a: CHEBI:83820 ! non-proteinogenic amino acid + [Term] id: CHEBI:33707 name: gamma-amino acid @@ -12051,6 +19069,27 @@ synonym: "copper group molecular entity" EXACT [ChEBI] is_a: CHEBI:33676 ! d-block molecular entity relationship: has_part CHEBI:33366 ! copper group element atom +[Term] +id: CHEBI:33747 +name: nickel group molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "nickel group molecular entities" RELATED [ChEBI] +synonym: "nickel group molecular entity" EXACT [ChEBI] +is_a: CHEBI:33676 ! d-block molecular entity +relationship: has_part CHEBI:33362 ! nickel group element atom + +[Term] +id: CHEBI:33749 +name: platinum molecular entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "platinum compounds" RELATED [ChEBI] +synonym: "platinum molecular entities" RELATED [ChEBI] +synonym: "platinum molecular entity" EXACT [ChEBI] +is_a: CHEBI:33747 ! nickel group molecular entity +relationship: has_part CHEBI:33364 ! platinum + [Term] id: CHEBI:33791 name: canonical nucleoside residue @@ -12075,19 +19114,6 @@ synonym: "Nuc" RELATED [CBN] synonym: "standard ribonucleoside residues" RELATED [ChEBI] is_a: CHEBI:33791 ! canonical nucleoside residue -[Term] -id: CHEBI:33793 -name: canonical deoxyribonucleoside residue -namespace: chebi_ontology -subset: 3_STAR -synonym: "canonical deoxyribonucleoside residues" RELATED [ChEBI] -synonym: "common 2'-deoxyribonucleoside residue" RELATED [CBN] -synonym: "common 2'-deoxyribonucleoside residues" RELATED [CBN] -synonym: "dN" RELATED [CBN] -synonym: "dNuc" RELATED [CBN] -synonym: "standard deoxyribonucleoside residues" RELATED [ChEBI] -is_a: CHEBI:33791 ! canonical nucleoside residue - [Term] id: CHEBI:33822 name: organic hydroxy compound @@ -12144,6 +19170,30 @@ xref: COMe:PRX000001 is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein +[Term] +id: CHEBI:33838 +name: nucleoside +namespace: chebi_ontology +alt_id: CHEBI:13661 +alt_id: CHEBI:25611 +alt_id: CHEBI:7647 +def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." [] +subset: 3_STAR +synonym: "a nucleoside" RELATED [UniProt] +synonym: "Nucleoside" EXACT [KEGG_COMPOUND] +synonym: "nucleosides" EXACT IUPAC_NAME [IUPAC] +synonym: "nucleosides" RELATED [ChEBI] +xref: KEGG:C00801 +xref: Wikipedia:Nucleoside +is_a: CHEBI:21731 ! N-glycosyl compound +is_a: CHEBI:26912 ! oxolanes +is_a: CHEBI:61120 ! nucleobase-containing molecular entity +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H8O3R2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "116.115" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "116.04734" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@H]1([C@H]([C@@H](*)[C@@H](O1)*)O)CO" xsd:string + [Term] id: CHEBI:33839 name: macromolecule @@ -12176,6 +19226,24 @@ subset: 3_STAR synonym: "monocyclic arenes" RELATED [ChEBI] is_a: CHEBI:33658 ! arene +[Term] +id: CHEBI:33848 +name: polycyclic arene +namespace: chebi_ontology +def: "A polycyclic aromatic hydrocarbon." [] +subset: 3_STAR +synonym: "PAH" RELATED [ChEBI] +synonym: "PAHs" RELATED [ChEBI] +synonym: "polycyclic arenes" RELATED [ChEBI] +synonym: "polycyclic aromatic hydrocarbons" RELATED [ChEBI] +xref: PMID:15198916 {source="Europe PMC"} +xref: PMID:25679824 {source="Europe PMC"} +xref: Wikipedia:Polycyclic_aromatic_hydrocarbon +is_a: CHEBI:33658 ! arene +is_a: CHEBI:33666 ! polycyclic hydrocarbon +relationship: has_role CHEBI:138015 ! endocrine disruptor +relationship: has_role CHEBI:50903 ! carcinogenic agent + [Term] id: CHEBI:33853 name: phenols @@ -12267,6 +19335,127 @@ synonym: "transition metal coordination entities" RELATED [ChEBI] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33497 ! transition element molecular entity +[Term] +id: CHEBI:33862 +name: platinum coordination entity +namespace: chebi_ontology +subset: 3_STAR +synonym: "platinum coordination compounds" RELATED [ChEBI] +synonym: "platinum coordination entities" RELATED [ChEBI] +synonym: "platinum coordination entity" EXACT [ChEBI] +is_a: CHEBI:33749 ! platinum molecular entity +is_a: CHEBI:33861 ! transition element coordination entity + +[Term] +id: CHEBI:3387 +name: carbamazepine +namespace: chebi_ontology +alt_id: CHEBI:115086 +def: "A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant." [] +subset: 3_STAR +synonym: "5-Carbamoyl-5H-dibenz(b,f)azepine" RELATED [ChemIDplus] +synonym: "5-carbamoyl-5H-dibenz[b,f]azepine" RELATED [NIST_Chemistry_WebBook] +synonym: "5-Carbamoyl-5H-dibenzo(b,f)azepine" RELATED [ChemIDplus] +synonym: "5-Carbamyl-5H-dibenzo(b,f)azepine" RELATED [ChemIDplus] +synonym: "5H-Dibenz(b,f)azepine-5-carboxamide" RELATED [ChemIDplus] +synonym: "5H-dibenzo[b,f]azepine-5-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Carbamazepen" RELATED [ChemIDplus] +synonym: "carbamazepina" RELATED INN [ChemIDplus] +synonym: "carbamazepine" RELATED INN [ChemIDplus] +synonym: "carbamazepinum" RELATED INN [ChemIDplus] +synonym: "Carnexiv" RELATED BRAND_NAME [ChemIDplus] +xref: Beilstein:1246090 {source="Beilstein"} +xref: CAS:298-46-4 {source="NIST Chemistry WebBook"} +xref: CAS:298-46-4 {source="ChemIDplus"} +xref: CAS:298-46-4 {source="KEGG COMPOUND"} +xref: Drug_Central:489 {source="DrugCentral"} +xref: DrugBank:DB00564 +xref: HMDB:HMDB0014704 +xref: KEGG:C06868 +xref: KEGG:D00252 +xref: LINCS:LSM-3610 +xref: Patent:US2004220187 +xref: Patent:US2007167446 +xref: Patent:US2011177136 +xref: Patent:US2011245283 +xref: Patent:US2948718 +xref: PMID:10411478 {source="ChEMBL"} +xref: PMID:11071486 {source="Europe PMC"} +xref: PMID:11129121 {source="Europe PMC"} +xref: PMID:11240598 {source="Europe PMC"} +xref: PMID:11475584 {source="Europe PMC"} +xref: PMID:11595204 {source="Europe PMC"} +xref: PMID:11888243 {source="Europe PMC"} +xref: PMID:11891095 {source="Europe PMC"} +xref: PMID:12073283 {source="Europe PMC"} +xref: PMID:12228880 {source="Europe PMC"} +xref: PMID:12475188 {source="Europe PMC"} +xref: PMID:12749779 {source="Europe PMC"} +xref: PMID:12799799 {source="Europe PMC"} +xref: PMID:12957643 {source="Europe PMC"} +xref: PMID:14160216 {source="Europe PMC"} +xref: PMID:14572037 {source="Europe PMC"} +xref: PMID:14581052 {source="Europe PMC"} +xref: PMID:14713026 {source="Europe PMC"} +xref: PMID:14723323 {source="Europe PMC"} +xref: PMID:15165631 {source="Europe PMC"} +xref: PMID:15557493 {source="Europe PMC"} +xref: PMID:15665743 {source="Europe PMC"} +xref: PMID:15683742 {source="Europe PMC"} +xref: PMID:15739418 {source="Europe PMC"} +xref: PMID:15820347 {source="Europe PMC"} +xref: PMID:15850602 {source="Europe PMC"} +xref: PMID:16033627 {source="Europe PMC"} +xref: PMID:16150575 {source="Europe PMC"} +xref: PMID:16245817 {source="Europe PMC"} +xref: PMID:16380297 {source="Europe PMC"} +xref: PMID:16394456 {source="Europe PMC"} +xref: PMID:16437428 {source="Europe PMC"} +xref: PMID:16538175 {source="Europe PMC"} +xref: PMID:16562645 {source="Europe PMC"} +xref: PMID:16616830 {source="Europe PMC"} +xref: PMID:16990009 {source="Europe PMC"} +xref: PMID:17027750 {source="Europe PMC"} +xref: PMID:17028629 {source="Europe PMC"} +xref: PMID:17207414 {source="Europe PMC"} +xref: PMID:17582711 {source="Europe PMC"} +xref: PMID:17873967 {source="Europe PMC"} +xref: PMID:17949959 {source="Europe PMC"} +xref: PMID:18163657 {source="Europe PMC"} +xref: PMID:18415623 {source="Europe PMC"} +xref: PMID:18637155 {source="Europe PMC"} +xref: PMID:18652684 {source="Europe PMC"} +xref: PMID:18656520 {source="Europe PMC"} +xref: PMID:18969759 {source="Europe PMC"} +xref: PMID:19135617 {source="Europe PMC"} +xref: PMID:19473818 {source="Europe PMC"} +xref: PMID:19741433 {source="Europe PMC"} +xref: PMID:19921623 {source="Europe PMC"} +xref: PMID:22322005 {source="Europe PMC"} +xref: PMID:27967303 {source="Europe PMC"} +xref: PMID:7602118 {source="Europe PMC"} +xref: Reaxys:1246090 {source="Reaxys"} +xref: Wikipedia:Carbamazepine +is_a: CHEBI:47804 ! dibenzoazepine +is_a: CHEBI:47857 ! ureas +relationship: has_role CHEBI:35477 ! antimanic drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35623 ! anticonvulsant +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:38633 ! sodium channel blocker +relationship: has_role CHEBI:52290 ! mitogen +relationship: has_role CHEBI:61115 ! EC 3.5.1.98 (histone deacetylase) inhibitor +relationship: has_role CHEBI:64370 ! glutamate transporter activator +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H12N2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FFGPTBGBLSHEPO-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "236.26860" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "236.09496" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)N1c2ccccc2C=Cc2ccccc12" xsd:string + [Term] id: CHEBI:33892 name: iron coordination entity @@ -12322,6 +19511,46 @@ subset: 3_STAR synonym: "macronutrients" RELATED [ChEBI] is_a: CHEBI:33284 ! nutrient +[Term] +id: CHEBI:33958 +name: halide salt +synonym: "halide salts" RELATED [] +synonym: "halides" RELATED [] +is_a: CHEBI:24866 ! salt +is_a: CHEBI:37578 ! halide +relationship: has_part CHEBI:16042 ! halide anion + +[Term] +id: CHEBI:34073 +name: Delta(1)-progesterone +namespace: chebi_ontology +def: "A 3-oxo Delta(4)-steroid that is progesterone which has been oxidised to introduce a double bond between positions 1 and 2." [] +subset: 3_STAR +synonym: "1,2-dehydroprogesterone" RELATED [ChemIDplus] +synonym: "1,2-didehydroprogesterone" RELATED [ChEBI] +synonym: "1-Dehydroprogesterone" RELATED [KEGG_COMPOUND] +synonym: "3,20-dioxo-1,4-pregnadiene" RELATED [ChEBI] +synonym: "3,20-dioxo-pregna-1,4-diene" RELATED [ChEBI] +synonym: "delta1-Progesterone" RELATED [KEGG_COMPOUND] +synonym: "Pregna-1,4-diene-3,20-dione" RELATED [KEGG_COMPOUND] +synonym: "pregna-1,4-diene-3,20-dione" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1999508 {source="Beilstein"} +xref: CAS:1162-54-5 {source="ChemIDplus"} +xref: CAS:1162-54-5 {source="KEGG COMPOUND"} +xref: KEGG:C14677 +xref: Reaxys:1999508 {source="Reaxys"} +is_a: CHEBI:36885 ! 20-oxo steroid +is_a: CHEBI:77166 ! 3-oxo-Delta(1),Delta(4)-steroid +relationship: has_functional_parent CHEBI:17026 ! progesterone +relationship: has_parent_hydride CHEBI:35508 ! steroid fundamental parent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H28O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h8,10,12,16-19H,4-7,9,11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QIEPWCSVQYUPIY-LEKSSAKUSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "312.44582" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "312.20893" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O" xsd:string + [Term] id: CHEBI:3424 name: carnitinium @@ -12347,6 +19576,62 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "162.20688" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "162.11247" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[N+](C)(C)CC(O)CC(O)=O" xsd:string +[Term] +id: CHEBI:34848 +name: mevastatin +namespace: chebi_ontology +def: "A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals." [] +subset: 3_STAR +synonym: "(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "antibiotic ML 236B" RELATED [ChemIDplus] +synonym: "Compactin" RELATED [KEGG_COMPOUND] +synonym: "CS 500" RELATED [ChemIDplus] +synonym: "Mevastatin" EXACT [KEGG_COMPOUND] +synonym: "mevastatin" EXACT [UniProt] +synonym: "mevastatin" RELATED INN [WHO_MedNet] +synonym: "mevastatina" RELATED INN [WHO_MedNet] +synonym: "mevastatine" RELATED INN [WHO_MedNet] +synonym: "mevastatinum" RELATED INN [WHO_MedNet] +synonym: "ML 236 B" RELATED [ChemIDplus] +synonym: "ML-236B" RELATED [KEGG_COMPOUND] +xref: CAS:73573-88-3 {source="KEGG COMPOUND"} +xref: CAS:73573-88-3 {source="ChemIDplus"} +xref: DrugBank:DB06693 +xref: KEGG:C13963 +xref: KNApSAcK:C00000564 +xref: LINCS:LSM-4123 +xref: Patent:DE2524355 +xref: Patent:US3983140 +xref: PMID:11283400 {source="Europe PMC"} +xref: PMID:12403272 {source="Europe PMC"} +xref: PMID:15274361 {source="Europe PMC"} +xref: PMID:15531285 {source="Europe PMC"} +xref: PMID:15786722 {source="Europe PMC"} +xref: PMID:18672387 {source="Europe PMC"} +xref: PMID:18936176 {source="Europe PMC"} +xref: PMID:20629200 {source="Europe PMC"} +xref: PMID:23918904 {source="Europe PMC"} +xref: PMID:24462564 {source="Europe PMC"} +xref: PMID:3170348 {source="Europe PMC"} +xref: PMID:3719857 {source="Europe PMC"} +xref: Reaxys:3630717 {source="Reaxys"} +xref: Wikipedia:Mevastatin +is_a: CHEBI:142348 ! hexahydronaphthalenes +is_a: CHEBI:26188 ! polyketide +is_a: CHEBI:75885 ! 2-pyranones +is_a: CHEBI:87632 ! statin (naturally occurring) +relationship: has_role CHEBI:35718 ! antifungal agent +relationship: has_role CHEBI:68495 ! apoptosis inducer +relationship: has_role CHEBI:76964 ! Penicillium metabolite +relationship: has_role CHEBI:77255 ! EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H34O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AJLFOPYRIVGYMJ-INTXDZFKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "390.51310" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "390.24062" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12" xsd:string + [Term] id: CHEBI:350546 name: serotonin(1+) @@ -12480,6 +19765,17 @@ synonym: "diterpeno" RELATED [IUPAC] synonym: "diterpenos" RELATED [IUPAC] is_a: CHEBI:35186 ! terpene +[Term] +id: CHEBI:35191 +name: triterpene +def: "A C30 terpene." [] +synonym: "Triterpen" RELATED [] +synonym: "triterpenes" EXACT [] +synonym: "triterpenes" RELATED [] +synonym: "triterpeno" RELATED [] +synonym: "triterpenos" RELATED [] +is_a: CHEBI:35186 ! terpene + [Term] id: CHEBI:35193 name: tetraterpene @@ -12503,6 +19799,29 @@ synonym: "surfactant" EXACT IUPAC_NAME [IUPAC] synonym: "surfactants" RELATED [ChEBI] is_a: CHEBI:63046 ! emulsifier +[Term] +id: CHEBI:35219 +name: plant growth retardant +namespace: chebi_ontology +alt_id: CHEBI:26154 +alt_id: CHEBI:26156 +subset: 3_STAR +synonym: "plant growth inhibitor" RELATED [ChEBI] +synonym: "plant growth inhibitors" RELATED [ChEBI] +synonym: "plant growth retardants" RELATED [ChEBI] +is_a: CHEBI:26155 ! plant growth regulator + +[Term] +id: CHEBI:35221 +name: antimetabolite +namespace: chebi_ontology +def: "A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [] +subset: 3_STAR +synonym: "antimetabolite" EXACT IUPAC_NAME [IUPAC] +synonym: "antimetabolites" RELATED [ChEBI] +xref: Wikipedia:Antimetabolite +is_a: CHEBI:52206 ! biochemical role + [Term] id: CHEBI:35222 name: inhibitor @@ -12527,6 +19846,15 @@ synonym: "catalyst" EXACT IUPAC_NAME [IUPAC] synonym: "Katalysator" RELATED [ChEBI] is_a: CHEBI:51086 ! chemical role +[Term] +id: CHEBI:35230 +name: fossil fuel +namespace: chebi_ontology +def: "A fuel such as coal, oil and natural gas which has formed over many years through the decomposition of deposited vegetation which was under extreme pressure of an overburden of earth." [] +subset: 3_STAR +synonym: "fossil fuel" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:33292 ! fuel + [Term] id: CHEBI:35235 name: L-cysteine zwitterion @@ -12604,6 +19932,15 @@ subset: 3_STAR synonym: "amino acid zwitterion" EXACT [ChEBI] is_a: CHEBI:27369 ! zwitterion +[Term] +id: CHEBI:35259 +name: benzofurans +namespace: chebi_ontology +alt_id: CHEBI:22721 +subset: 3_STAR +is_a: CHEBI:38104 ! oxacycle +is_a: CHEBI:38166 ! organic heteropolycyclic compound + [Term] id: CHEBI:35267 name: quaternary ammonium ion @@ -12660,6 +19997,17 @@ synonym: "ammonium betaines" RELATED [ChEBI] is_a: CHEBI:26469 ! quaternary nitrogen compound is_a: CHEBI:35281 ! onium betaine +[Term] +id: CHEBI:35286 +name: iminium ion +namespace: chebi_ontology +def: "Cations of structure R2C=N(+)R2." [] +subset: 3_STAR +synonym: "iminium cations" RELATED [ChEBI] +synonym: "iminium ion" EXACT [ChEBI] +synonym: "iminium ions" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation + [Term] id: CHEBI:35287 name: acylcholine @@ -12691,6 +20039,78 @@ synonym: "fused-ring polycyclic compounds" RELATED [ChEBI] synonym: "polycyclic fused-ring compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound +[Term] +id: CHEBI:35294 +name: carbopolycyclic compound +namespace: chebi_ontology +def: "A polyclic compound in which all of the ring members are carbon atoms." [] +subset: 3_STAR +synonym: "carbopolycyclic compounds" RELATED [ChEBI] +is_a: CHEBI:33598 ! carbocyclic compound +is_a: CHEBI:35295 ! homopolycyclic compound + +[Term] +id: CHEBI:35295 +name: homopolycyclic compound +namespace: chebi_ontology +subset: 3_STAR +synonym: "homopolycyclic compounds" RELATED [ChEBI] +is_a: CHEBI:33597 ! homocyclic compound +is_a: CHEBI:33635 ! polycyclic compound + +[Term] +id: CHEBI:35296 +name: ortho-fused polycyclic arene +namespace: chebi_ontology +subset: 3_STAR +synonym: "ortho-fused polycyclic arenes" RELATED [ChEBI] +is_a: CHEBI:33848 ! polycyclic arene +is_a: CHEBI:35427 ! ortho-fused polycyclic hydrocarbon + +[Term] +id: CHEBI:35297 +name: acene +namespace: chebi_ontology +def: "A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement." [] +subset: 3_STAR +synonym: "Acen" RELATED [ChEBI] +synonym: "acene" EXACT [IUPAC] +synonym: "acenes" EXACT IUPAC_NAME [IUPAC] +synonym: "Azen" RELATED [ChEBI] +synonym: "polyacenes" RELATED [ChEBI] +xref: Wikipedia:Acene +is_a: CHEBI:35296 ! ortho-fused polycyclic arene +is_a: CHEBI:51269 ! acenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H8.(C4H2)n" xsd:string + +[Term] +id: CHEBI:35312 +name: pentoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "pentoside" EXACT [ChEBI] +synonym: "pentosides" RELATED [ChEBI] +is_a: CHEBI:24400 ! glycoside + +[Term] +id: CHEBI:35313 +name: hexoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "hexoside" EXACT [ChEBI] +synonym: "hexosides" RELATED [ChEBI] +is_a: CHEBI:24400 ! glycoside + +[Term] +id: CHEBI:35315 +name: deoxy hexoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "deoxy hexoside" EXACT [ChEBI] +synonym: "deoxy hexosides" RELATED [ChEBI] +is_a: CHEBI:24400 ! glycoside + [Term] id: CHEBI:35337 name: central nervous system stimulant @@ -12707,6 +20127,16 @@ synonym: "CNS stimulant" RELATED [ChEBI] xref: Wikipedia:Central_nervous_system_stimulants is_a: CHEBI:35470 ! central nervous system drug +[Term] +id: CHEBI:35338 +name: amphetamines +namespace: chebi_ontology +def: "Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine." [] +subset: 3_STAR +synonym: "amphetamine drug" RELATED [ChEBI] +is_a: CHEBI:32952 ! amine +relationship: has_role CHEBI:35337 ! central nervous system stimulant + [Term] id: CHEBI:35341 name: steroid @@ -12715,6 +20145,7 @@ alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." [] +def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene, so may be considered as triterpenoids." [] subset: 3_STAR synonym: "a steroid" RELATED [UniProt] synonym: "Steroid" EXACT [KEGG_COMPOUND] @@ -12751,10 +20182,10 @@ alt_id: CHEBI:19176 alt_id: CHEBI:794 def: "A 17-hydroxy steroid in which the hydroxy group at position 17 has a beta-configuration." [] subset: 3_STAR -synonym: "17beta-hydroxy steroid" EXACT [UniProt] synonym: "17beta-hydroxy steroids" RELATED [ChEBI] synonym: "17beta-hydroxysteroid" RELATED [KEGG_COMPOUND] synonym: "17beta-hydroxysteroids" RELATED [ChEBI] +synonym: "a 17beta-hydroxy steroid" RELATED [UniProt] xref: KEGG:C03051 xref: MetaCyc:17-beta-Hydroxysteroids is_a: CHEBI:36838 ! 17-hydroxy steroid @@ -12844,6 +20275,67 @@ synonym: "organonitrogens" RELATED [ChEBI] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity +[Term] +id: CHEBI:35358 +name: sulfonamide +namespace: chebi_ontology +def: "An amide of a sulfonic acid RS(=O)2NR'2." [] +subset: 3_STAR +synonym: "sulfonamides" EXACT IUPAC_NAME [IUPAC] +synonym: "sulfonamides" RELATED [ChEBI] +xref: PMID:11498380 {source="Europe PMC"} +xref: PMID:2434548 {source="Europe PMC"} +xref: PMID:26811268 {source="Europe PMC"} +xref: PMID:26832216 {source="Europe PMC"} +xref: Wikipedia:Sulfonamide +is_a: CHEBI:33256 ! primary amide +is_a: CHEBI:33261 ! organosulfur compound +is_a: CHEBI:33552 ! sulfonic acid derivative +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "NO2SR3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "78.07100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "77.96497" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]S(=O)(=O)N([*])[*]" xsd:string + +[Term] +id: CHEBI:35359 +name: carboxamidine +namespace: chebi_ontology +def: "Compounds having the structure RC(=NR)NR2. The term is used as a suffix in systematic nomenclature to denote the -C(=NH)NH2 group including its carbon atom." [] +subset: 3_STAR +synonym: "Amidines" RELATED [KEGG_COMPOUND] +synonym: "carboxamidines" EXACT IUPAC_NAME [IUPAC] +synonym: "carboxamidines" RELATED [ChEBI] +xref: KEGG:C06060 +is_a: CHEBI:2634 ! amidine +is_a: CHEBI:35352 ! organonitrogen compound + +[Term] +id: CHEBI:35362 +name: hydrazide +namespace: chebi_ontology +def: "Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC)." [] +subset: 3_STAR +synonym: "hydrazides" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrazides" RELATED [ChEBI] +is_a: CHEBI:51143 ! nitrogen molecular entity + +[Term] +id: CHEBI:35363 +name: carbohydrazide +namespace: chebi_ontology +def: "A hydrazide consisting of hydrazine carrying one or more carboacyl groups." [] +subset: 3_STAR +synonym: "carbohydrazides" EXACT IUPAC_NAME [IUPAC] +synonym: "carbohydrazides" RELATED [ChEBI] +is_a: CHEBI:35352 ! organonitrogen compound +is_a: CHEBI:35362 ! hydrazide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CN2OR4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "56.024" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "56.00106" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(C(*)=O)(N(*)*)*" xsd:string + [Term] id: CHEBI:35366 name: fatty acid @@ -12851,6 +20343,7 @@ namespace: chebi_ontology alt_id: CHEBI:13633 alt_id: CHEBI:24024 alt_id: CHEBI:4984 +def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax." [] def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids." [] subset: 3_STAR synonym: "acide gras" RELATED [ChEBI] @@ -12893,6 +20386,38 @@ synonym: "Monosacharid" RELATED [ChEBI] xref: KEGG:C06698 is_a: CHEBI:16646 ! carbohydrate +[Term] +id: CHEBI:3540 +name: cephalotaxine +namespace: chebi_ontology +def: "A benzazepine alkaloid isolated from Cephalotaxus harringtonia." [] +subset: 3_STAR +synonym: "(-)-Cephalotaxine" RELATED [ChemIDplus] +synonym: "(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-ol" RELATED [IUPAC] +synonym: "Cephalotaxine" EXACT [KEGG_COMPOUND] +synonym: "cephalotaxine" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:628324 {source="Beilstein"} +xref: CAS:24316-19-6 {source="KEGG COMPOUND"} +xref: CAS:24316-19-6 {source="ChemIDplus"} +xref: KEGG:C10580 +xref: KNApSAcK:C00002324 +xref: KNApSAcK:C00027319 +xref: Reaxys:628324 {source="Reaxys"} +is_a: CHEBI:35681 ! secondary alcohol +is_a: CHEBI:38164 ! organic heteropentacyclic compound +is_a: CHEBI:38523 ! benzazepine alkaloid +is_a: CHEBI:38527 ! benzazepine alkaloid fundamental parent +is_a: CHEBI:47985 ! enol ether +is_a: CHEBI:50996 ! tertiary amino compound +is_a: CHEBI:59770 ! cyclic acetal +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H21NO4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YMNCVRSYJBNGLD-KURKYZTESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "315.36368" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "315.14706" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12[C@H](O)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21" xsd:string + [Term] id: CHEBI:35406 name: oxoanion @@ -12907,6 +20432,34 @@ synonym: "oxoanions" RELATED [ChEBI] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion +[Term] +id: CHEBI:35427 +name: ortho-fused polycyclic hydrocarbon +namespace: chebi_ontology +subset: 3_STAR +synonym: "ortho-fused polycyclic hydrocarbon" EXACT [ChEBI] +synonym: "ortho-fused polycyclic hydrocarbons" RELATED [ChEBI] +is_a: CHEBI:33637 ! ortho-fused compound + +[Term] +id: CHEBI:35436 +name: D-glucoside +namespace: chebi_ontology +alt_id: CHEBI:21009 +alt_id: CHEBI:4173 +def: "Any glucoside in which the glycoside group is derived from D-glucose." [] +subset: 3_STAR +synonym: "a D-glucoside" RELATED [UniProt] +synonym: "D-Glucoside" EXACT [KEGG_COMPOUND] +synonym: "D-glucosides" RELATED [ChEBI] +xref: KEGG:C01798 +is_a: CHEBI:24278 ! glucoside +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H11O6R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "179.148" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "179.05556" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C@@H]1(OC([C@H](O)[C@H]([C@@H]1O)O)O*)CO" xsd:string + [Term] id: CHEBI:35441 name: antiinfective agent @@ -12919,6 +20472,113 @@ synonym: "antiinfective agents" RELATED [ChEBI] synonym: "antiinfective drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:35442 +name: antiparasitic agent +namespace: chebi_ontology +def: "A substance used to treat or prevent parasitic infections." [] +subset: 3_STAR +synonym: "antiparasitic drugs" RELATED [ChEBI] +synonym: "antiparasitics" RELATED [ChEBI] +synonym: "parasiticides" RELATED [ChEBI] +xref: Wikipedia:Antiparasitic +is_a: CHEBI:35441 ! antiinfective agent + +[Term] +id: CHEBI:35457 +name: EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor +namespace: chebi_ontology +def: "An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1)." [] +subset: 3_STAR +synonym: "ACE inhibitor" RELATED [ChEBI] +synonym: "ACE inhibitors" RELATED [ChEBI] +synonym: "angiotensin I-converting enzyme inhibitor" RELATED [ChEBI] +synonym: "angiotensin I-converting enzyme inhibitors" RELATED [ChEBI] +synonym: "angiotensin-converting enzyme inhibitor" RELATED [ChEBI] +synonym: "angiotensin-converting enzyme inhibitors" RELATED [ChEBI] +synonym: "carboxycathepsin inhibitor" RELATED [ChEBI] +synonym: "carboxycathepsin inhibitors" RELATED [ChEBI] +synonym: "DCP inhibitor" RELATED [ChEBI] +synonym: "DCP inhibitors" RELATED [ChEBI] +synonym: "dipeptidase inhibitor" RELATED [ChEBI] +synonym: "dipeptidase inhibitors" RELATED [ChEBI] +synonym: "dipeptide hydrolase inhibitor" RELATED [ChEBI] +synonym: "dipeptide hydrolase inhibitors" RELATED [ChEBI] +synonym: "dipeptidyl carboxypeptidase I inhibitor" RELATED [ChEBI] +synonym: "dipeptidyl carboxypeptidase I inhibitors" RELATED [ChEBI] +synonym: "dipeptidyl carboxypeptidase inhibitor" RELATED [ChEBI] +synonym: "dipeptidyl carboxypeptidase inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.15.1 inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.15.1 inhibitors" RELATED [ChEBI] +synonym: "endothelial cell peptidyl dipeptidase inhibitor" RELATED [ChEBI] +synonym: "endothelial cell peptidyl dipeptidase inhibitors" RELATED [ChEBI] +synonym: "kininase II inhibitor" RELATED [ChEBI] +synonym: "kininase II inhibitors" RELATED [ChEBI] +synonym: "PDH inhibitor" RELATED [ChEBI] +synonym: "PDH inhibitors" RELATED [ChEBI] +synonym: "peptidase P inhibitor" RELATED [ChEBI] +synonym: "peptidase P inhibitors" RELATED [ChEBI] +synonym: "peptidyl dipeptidase A inhibitor" RELATED [ChEBI] +synonym: "peptidyl dipeptidase A inhibitors" RELATED [ChEBI] +synonym: "peptidyl dipeptidase I inhibitor" RELATED [ChEBI] +synonym: "peptidyl dipeptidase I inhibitors" RELATED [ChEBI] +synonym: "peptidyl dipeptidase-4 inhibitor" RELATED [ChEBI] +synonym: "peptidyl dipeptidase-4 inhibitors" RELATED [ChEBI] +synonym: "peptidyl dipeptide hydrolase inhibitor" RELATED [ChEBI] +synonym: "peptidyl dipeptide hydrolase inhibitors" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase A (EC 3.4.15.1) inhibitor" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase A (EC 3.4.15.1) inhibitors" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase A inhibitor" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase A inhibitors" RELATED [ChEBI] +synonym: "peptidyl-dipeptide hydrolase inhibitor" RELATED [ChEBI] +synonym: "peptidyl-dipeptide hydrolase inhibitors" RELATED [ChEBI] +synonym: "peptidyldipeptide hydrolase inhibitor" RELATED [ChEBI] +synonym: "peptidyldipeptide hydrolase inhibitors" RELATED [ChEBI] +xref: Wikipedia:ACE_inhibitor +is_a: CHEBI:35674 ! antihypertensive agent +is_a: CHEBI:76782 ! EC 3.4.15.* (peptidyl-dipeptidase) inhibitor + +[Term] +id: CHEBI:35467 +name: phosphorodiamide +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:17102 ! phosphoramide + +[Term] +id: CHEBI:35468 +name: triazene +namespace: chebi_ontology +subset: 3_STAR +synonym: "1-triazene" RELATED [ChemIDplus] +synonym: "triaz-1-ene" EXACT IUPAC_NAME [IUPAC] +synonym: "triazene" EXACT [NIST_Chemistry_WebBook] +xref: CAS:15056-34-5 {source="NIST Chemistry WebBook"} +xref: CAS:15056-34-5 {source="ChemIDplus"} +xref: Gmelin:49028 {source="Gmelin"} +is_a: CHEBI:35106 ! nitrogen hydride +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H3N3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N3/c1-3-2/h(H3,1,2)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AYNNSCRYTDRFCP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "45.04404" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.03270" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NN=N" xsd:string + +[Term] +id: CHEBI:35469 +name: antidepressant +namespace: chebi_ontology +def: "Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions." [] +subset: 3_STAR +synonym: "antidepressant drugs" RELATED [ChEBI] +synonym: "antidepressants" RELATED [ChEBI] +synonym: "thymoanaleptics" RELATED [ChEBI] +synonym: "thymoleptic drugs" RELATED [ChEBI] +synonym: "thymoleptics" RELATED [ChEBI] +is_a: CHEBI:35471 ! psychotropic drug + [Term] id: CHEBI:35470 name: central nervous system drug @@ -12930,6 +20590,19 @@ synonym: "CNS agent" RELATED [ChEBI] synonym: "CNS drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:35471 +name: psychotropic drug +namespace: chebi_ontology +def: "A loosely defined grouping of drugs that have effects on psychological function." [] +subset: 3_STAR +synonym: "psychoactive agent" RELATED [ChEBI] +synonym: "psychoactive drugs" RELATED [ChEBI] +synonym: "psychopharmaceuticals" RELATED [ChEBI] +synonym: "psychotropic drugs" RELATED [ChEBI] +xref: Wikipedia:Psychotropic_drug +is_a: CHEBI:35470 ! central nervous system drug + [Term] id: CHEBI:35472 name: anti-inflammatory drug @@ -12943,6 +20616,82 @@ synonym: "antiinflammatory drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:67079 ! anti-inflammatory agent +[Term] +id: CHEBI:35473 +name: tranquilizing drug +namespace: chebi_ontology +def: "A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour." [] +subset: 3_STAR +synonym: "ataractics" RELATED [ChEBI] +synonym: "tranquilising drug" RELATED [ChEBI] +synonym: "tranquilizing drugs" RELATED [ChEBI] +synonym: "tranquillising agent" RELATED [ChEBI] +synonym: "tranquillizing agents" RELATED [ChEBI] +is_a: CHEBI:35471 ! psychotropic drug +is_a: CHEBI:35488 ! central nervous system depressant + +[Term] +id: CHEBI:35474 +name: anxiolytic drug +namespace: chebi_ontology +def: "Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions." [] +subset: 3_STAR +synonym: "anti-anxiety agents" RELATED [ChEBI] +synonym: "anti-anxiety drugs" RELATED [ChEBI] +synonym: "anxiolytic agents" RELATED [ChEBI] +synonym: "anxiolytics" RELATED [ChEBI] +synonym: "minor tranquilisers" RELATED [ChEBI] +synonym: "minor tranquilizers" RELATED [ChEBI] +synonym: "minor tranquilizing agents" RELATED [ChEBI] +is_a: CHEBI:35473 ! tranquilizing drug + +[Term] +id: CHEBI:35475 +name: non-steroidal anti-inflammatory drug +namespace: chebi_ontology +def: "An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins." [] +subset: 3_STAR +synonym: "non-steroidal anti-inflammatory agent" RELATED [ChEBI] +synonym: "non-steroidal anti-inflammatory drugs" RELATED [ChEBI] +synonym: "NSAID" RELATED [ChEBI] +synonym: "NSAIDs" RELATED [ChEBI] +xref: Wikipedia:Non-steroidal_anti-inflammatory_drug +is_a: CHEBI:35472 ! anti-inflammatory drug +is_a: CHEBI:35842 ! antirheumatic drug + +[Term] +id: CHEBI:35476 +name: antipsychotic agent +namespace: chebi_ontology +def: "Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [] +subset: 3_STAR +synonym: "antipsychotic agents" RELATED [ChEBI] +synonym: "antipsychotic drug" RELATED [ChEBI] +synonym: "antipsychotic drugs" RELATED [ChEBI] +synonym: "antipsychotics" RELATED [ChEBI] +synonym: "antipsychotiques" RELATED [ChEBI] +synonym: "grosser Tranquilizer" RELATED [ChEBI] +synonym: "major tranquilizers" RELATED [ChEBI] +synonym: "major tranquilizing agents" RELATED [ChEBI] +synonym: "neuroleptic" RELATED [ChEBI] +synonym: "neuroleptic agents" RELATED [ChEBI] +synonym: "neuroleptics" RELATED [ChEBI] +synonym: "Neuroleptikum" RELATED [ChEBI] +synonym: "neuroleptique" RELATED [ChEBI] +synonym: "neuroleptiques" RELATED [ChEBI] +is_a: CHEBI:35473 ! tranquilizing drug + +[Term] +id: CHEBI:35477 +name: antimanic drug +namespace: chebi_ontology +def: "Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders." [] +subset: 3_STAR +synonym: "antimanic agent" RELATED [ChEBI] +synonym: "antimanic drugs" RELATED [ChEBI] +synonym: "antimanics" RELATED [ChEBI] +is_a: CHEBI:35473 ! tranquilizing drug + [Term] id: CHEBI:35479 name: alkali metal salt @@ -12952,6 +20701,36 @@ synonym: "alkali metal salts" RELATED [ChEBI] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity +[Term] +id: CHEBI:35480 +name: analgesic +namespace: chebi_ontology +def: "An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms." [] +subset: 3_STAR +is_a: CHEBI:23888 ! drug +is_a: CHEBI:52210 ! pharmacological role + +[Term] +id: CHEBI:35481 +name: non-narcotic analgesic +namespace: chebi_ontology +def: "A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors." [] +subset: 3_STAR +is_a: CHEBI:35480 ! analgesic + +[Term] +id: CHEBI:35482 +name: opioid analgesic +namespace: chebi_ontology +def: "A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood." [] +subset: 3_STAR +synonym: "narcotic" RELATED [ChEBI] +synonym: "narcotic analgesic" RELATED [ChEBI] +synonym: "narcotic analgesics" RELATED [ChEBI] +synonym: "narcotics" RELATED [ChEBI] +synonym: "opioid analgesics" RELATED [ChEBI] +is_a: CHEBI:35480 ! analgesic + [Term] id: CHEBI:35488 name: central nervous system depressant @@ -12962,6 +20741,64 @@ synonym: "central nervous system depressants" RELATED [ChEBI] synonym: "CNS depressants" RELATED [ChEBI] is_a: CHEBI:35470 ! central nervous system drug +[Term] +id: CHEBI:35493 +name: antipyretic +namespace: chebi_ontology +def: "A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever." [] +subset: 3_STAR +synonym: "anti-pyretic" RELATED [ChEBI] +xref: Wikipedia:Antipyretic +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:35496 +name: fluorobenzenes +namespace: chebi_ontology +def: "Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group." [] +subset: 3_STAR +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:37143 ! organofluorine compound + +[Term] +id: CHEBI:35498 +name: diuretic +namespace: chebi_ontology +def: "An agent that promotes the excretion of urine through its effects on kidney function." [] +subset: 3_STAR +synonym: "diuretics" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:35504 +name: addition compound +namespace: chebi_ontology +def: "An addition compound contains two or more simpler compounds that can be packed in a definite ratio into a crystal. The term covers donor-acceptor complexes (adducts) and a variety of lattice compounds." [] +subset: 3_STAR +synonym: "addition compounds" RELATED [ChEBI] +is_a: CHEBI:37577 ! heteroatomic molecular entity + +[Term] +id: CHEBI:35505 +name: hydrate +namespace: chebi_ontology +def: "An addition compound that contains water in weak chemical combination with another compound." [] +subset: 3_STAR +synonym: "hidrato" RELATED [ChEBI] +synonym: "hidratos" RELATED [ChEBI] +synonym: "Hydrat" RELATED [ChEBI] +synonym: "hydrates" RELATED [ChEBI] +is_a: CHEBI:35504 ! addition compound +relationship: has_part CHEBI:15377 ! water + +[Term] +id: CHEBI:35506 +name: alkaloid fundamental parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "alkaloid fundamental parents" RELATED [ChEBI] +is_a: CHEBI:35507 ! natural product fundamental parent + [Term] id: CHEBI:35507 name: natural product fundamental parent @@ -13083,6 +20920,56 @@ synonym: "hypoglycemic drug" RELATED [ChEBI] synonym: "hypoglycemic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:35530 +name: beta-adrenergic antagonist +namespace: chebi_ontology +def: "An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety." [] +subset: 3_STAR +synonym: "beta-adrenergic antagonists" RELATED [ChEBI] +synonym: "beta-adrenergic blocker" RELATED [ChEBI] +synonym: "beta-adrenergic blockers" RELATED [ChEBI] +synonym: "beta-adrenergic receptor blockaders" RELATED [ChEBI] +synonym: "beta-adrenoceptor antagonists" RELATED [IUPHAR] +synonym: "beta-blocker" RELATED [ChEBI] +synonym: "beta-blockers" RELATED [ChEBI] +is_a: CHEBI:37887 ! adrenergic antagonist +is_a: CHEBI:48540 ! beta-adrenergic drug + +[Term] +id: CHEBI:35544 +name: EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor +namespace: chebi_ontology +def: "A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes." [] +subset: 3_STAR +synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "(PG)H synthase inhibitor" RELATED [ChEBI] +synonym: "(PG)H synthase inhibitors" RELATED [ChEBI] +synonym: "COX inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase (EC 1.14.99.1) inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase (EC 1.14.99.1) inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.99.1 (cyclooxygenase) inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.99.1 (cyclooxygenase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.99.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.99.1 inhibitors" RELATED [ChEBI] +synonym: "fatty acid cyclooxygenase inhibitor" RELATED [ChEBI] +synonym: "fatty acid cyclooxygenase inhibitors" RELATED [ChEBI] +synonym: "PG synthetase inhibitor" RELATED [ChEBI] +synonym: "PG synthetase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin endoperoxide synthetase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin endoperoxide synthetase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin G/H synthase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin G/H synthase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin synthase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin synthase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin synthetase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin synthetase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76840 ! EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor + [Term] id: CHEBI:35552 name: heterocyclic organic fundamental parent @@ -13177,6 +21064,93 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H7N" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "117.148" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "117.05785" xsd:string +[Term] +id: CHEBI:35584 +name: purine +namespace: chebi_ontology +def: "A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines." [] +subset: 3_STAR +synonym: "purine" EXACT IUPAC_NAME [IUPAC] +xref: HMDB:HMDB0001366 +xref: KEGG:C15587 +xref: MetaCyc:PURINE +xref: PMID:12865945 {source="Europe PMC"} +xref: PMID:24088627 {source="Europe PMC"} +is_a: CHEBI:26401 ! purines +is_a: CHEBI:35570 ! mancude organic heterobicyclic parent +relationship: has_role CHEBI:78675 ! fundamental metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.112" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string + +[Term] +id: CHEBI:35586 +name: 1H-purine +namespace: chebi_ontology +def: "The 1H-tautomer of purine." [] +subset: 3_STAR +synonym: "1H-purine" EXACT [ChEBI] +xref: Gmelin:2379911 {source="Gmelin"} +is_a: CHEBI:35584 ! purine +relationship: is_tautomer_of CHEBI:17258 ! 7H-purine +relationship: is_tautomer_of CHEBI:35588 ! 3H-purine +relationship: is_tautomer_of CHEBI:35589 ! 9H-purine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11210" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc2c[nH]cnc2n1" xsd:string + +[Term] +id: CHEBI:35588 +name: 3H-purine +namespace: chebi_ontology +def: "The 3H-tautomer of purine." [] +subset: 3_STAR +synonym: "3H-purine" EXACT IUPAC_NAME [IUPAC] +xref: PMID:6149478 {source="Europe PMC"} +xref: PMID:7178185 {source="Europe PMC"} +xref: PMID:7296170 {source="Europe PMC"} +xref: Reaxys:1210196 {source="Reaxys"} +is_a: CHEBI:35584 ! purine +relationship: is_tautomer_of CHEBI:17258 ! 7H-purine +relationship: is_tautomer_of CHEBI:35586 ! 1H-purine +relationship: is_tautomer_of CHEBI:35589 ! 9H-purine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1nc2cnc[nH]c2n1" xsd:string + +[Term] +id: CHEBI:35589 +name: 9H-purine +namespace: chebi_ontology +def: "The 9H-tautomer of purine." [] +subset: 3_STAR +synonym: "9H-purine" EXACT IUPAC_NAME [IUPAC] +synonym: "9H-purine" EXACT [UniProt] +xref: Beilstein:606899 {source="Beilstein"} +xref: CAS:120-73-0 {source="NIST Chemistry WebBook"} +xref: Gmelin:3120 {source="Gmelin"} +xref: Wikipedia:Purine +is_a: CHEBI:35584 ! purine +relationship: is_tautomer_of CHEBI:17258 ! 7H-purine +relationship: is_tautomer_of CHEBI:35586 ! 1H-purine +relationship: is_tautomer_of CHEBI:35588 ! 3H-purine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KDCGOANMDULRCW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ncc2nc[nH]c2n1" xsd:string + [Term] id: CHEBI:35604 name: carbon oxoanion @@ -13201,6 +21175,19 @@ synonym: "oxoacids of carbon" RELATED [ChEBI] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound +[Term] +id: CHEBI:35610 +name: antineoplastic agent +namespace: chebi_ontology +def: "A substance that inhibits or prevents the proliferation of neoplasms." [] +subset: 3_STAR +synonym: "anticancer agent" RELATED [ChEBI] +synonym: "anticancer agents" RELATED [ChEBI] +synonym: "antineoplastic" RELATED [ChEBI] +synonym: "antineoplastic agents" RELATED [ChEBI] +synonym: "cytostatic" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:35617 name: flavouring agent @@ -13214,6 +21201,15 @@ synonym: "flavour enhancers" RELATED [ChEBI] synonym: "flavouring agents" RELATED [ChEBI] is_a: CHEBI:64047 ! food additive +[Term] +id: CHEBI:35618 +name: aromatic ether +namespace: chebi_ontology +def: "Any ether in which the oxygen is attached to at least one aryl substituent." [] +subset: 3_STAR +is_a: CHEBI:25698 ! ether +is_a: CHEBI:33659 ! organic aromatic compound + [Term] id: CHEBI:35620 name: vasodilator agent @@ -13224,6 +21220,71 @@ synonym: "vasodilator" RELATED [ChEBI] synonym: "vasodilator agents" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug +[Term] +id: CHEBI:35623 +name: anticonvulsant +namespace: chebi_ontology +def: "A drug used to prevent seizures or reduce their severity." [] +subset: 3_STAR +synonym: "anti-convulsant" RELATED [ChEBI] +synonym: "anti-convulsants" RELATED [ChEBI] +synonym: "anti-convulsive agent" RELATED [ChEBI] +synonym: "anti-convulsive agents" RELATED [ChEBI] +synonym: "anticonvulsants" RELATED [ChEBI] +synonym: "anticonvulsive agent" RELATED [ChEBI] +synonym: "anticonvulsive agents" RELATED [ChEBI] +synonym: "antiepileptic" RELATED [ChEBI] +synonym: "antiepileptics" RELATED [ChEBI] +synonym: "Antiepileptika" RELATED [ChEBI] +synonym: "Antiepileptikum" RELATED [ChEBI] +synonym: "antiepileptique" RELATED [ChEBI] +synonym: "antiepileptiques" RELATED [ChEBI] +synonym: "Antikonvulsiva" RELATED [ChEBI] +synonym: "Antikonvulsivum" RELATED [ChEBI] +is_a: CHEBI:35488 ! central nervous system depressant + +[Term] +id: CHEBI:35624 +name: azaspiro compound +namespace: chebi_ontology +def: "An azaspiro compound is a spiro compound in which at least one of the cyclic components is a nitrogen heterocyle." [] +subset: 3_STAR +synonym: "azaspiro compound" EXACT [ChEBI] +synonym: "azaspiro compounds" RELATED [ChEBI] +is_a: CHEBI:33599 ! spiro compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:35634 +name: EC 1.17.3.2 (xanthine oxidase) inhibitor +namespace: chebi_ontology +def: "An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2)." [] +subset: 3_STAR +synonym: "EC 1.17.3.2 (xanthine oxidase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.3.2 inhibitor" RELATED [ChEBI] +synonym: "EC 1.17.3.2 inhibitors" RELATED [ChEBI] +synonym: "hypoxanthine oxidase inhibitor" RELATED [ChEBI] +synonym: "hypoxanthine oxidase inhibitors" RELATED [ChEBI] +synonym: "hypoxanthine-xanthine oxidase inhibitor" RELATED [ChEBI] +synonym: "hypoxanthine-xanthine oxidase inhibitors" RELATED [ChEBI] +synonym: "hypoxanthine:oxygen oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "hypoxanthine:oxygen oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "Schardinger enzyme inhibitor" RELATED [ChEBI] +synonym: "Schardinger enzyme inhibitors" RELATED [ChEBI] +synonym: "xanthine oxidase (EC 1.17.3.2) inhibitor" RELATED [ChEBI] +synonym: "xanthine oxidase (EC 1.17.3.2) inhibitors" RELATED [ChEBI] +synonym: "xanthine oxidase inhibitor" RELATED [ChEBI] +synonym: "xanthine oxidase inhibitors" RELATED [ChEBI] +synonym: "xanthine oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "xanthine oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "xanthine:O2 oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "xanthine:O2 oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "xanthine:oxygen oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "xanthine:oxygen oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "xanthine:xanthine oxidase inhibitor" RELATED [ChEBI] +synonym: "xanthine:xanthine oxidase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76850 ! EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor + [Term] id: CHEBI:35640 name: adrenergic uptake inhibitor @@ -13240,6 +21301,117 @@ synonym: "norepinephrine reuptake inhibitors" RELATED [ChEBI] synonym: "NRI" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent +[Term] +id: CHEBI:35649 +name: morphinan +namespace: chebi_ontology +subset: 3_STAR +synonym: "morphinan" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1375527 "Beilstein" +xref: Beilstein:1375527 {source="Beilstein"} +is_a: CHEBI:25418 ! morphinane alkaloid +is_a: CHEBI:38515 ! isoquinoline alkaloid fundamental parent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H21N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H21N/c1-2-6-13-12(5-1)11-15-14-7-3-4-8-16(13,14)9-10-17-15/h1-2,5-6,14-15,17H,3-4,7-11H2/t14-,15+,16-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "INAXVFBXDYWQFN-XHSDSOJGSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "227.34468" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "227.16740" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCC[C@@]11CCN[C@@H]2Cc2ccccc12" xsd:string + +[Term] +id: CHEBI:35662 +name: terpenoid fundamental parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "terpenoid fundamental parents" RELATED [ChEBI] +is_a: CHEBI:35507 ! natural product fundamental parent + +[Term] +id: CHEBI:35664 +name: EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor +namespace: chebi_ontology +def: "Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme." [] +subset: 3_STAR +synonym: "HMG-CoA reductase inhibitor" RELATED [ChEBI] +synonym: "HMG-CoA reductase inhibitors" RELATED [ChEBI] +synonym: "hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [ChEBI] +synonym: "hydroxymethylglutaryl-CoA reductase inhibitors" RELATED [ChEBI] +xref: PMID:1464741 {source="Europe PMC"} +xref: PMID:15531285 {source="Europe PMC"} +xref: PMID:20467214 {source="Europe PMC"} +xref: Wikipedia:HMG-CoA_reductase +is_a: CHEBI:76835 ! EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor + +[Term] +id: CHEBI:35666 +name: thiopurine +namespace: chebi_ontology +alt_id: CHEBI:26974 +alt_id: CHEBI:35665 +alt_id: CHEBI:9563 +subset: 3_STAR +synonym: "mercaptopurines" RELATED [ChEBI] +synonym: "sulfanylpurines" RELATED [ChEBI] +synonym: "thiopurines" RELATED [ChEBI] +is_a: CHEBI:16385 ! organic sulfide +is_a: CHEBI:26401 ! purines + +[Term] +id: CHEBI:35674 +name: antihypertensive agent +namespace: chebi_ontology +def: "Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism." [] +subset: 3_STAR +synonym: "antihypertensive" RELATED [ChEBI] +synonym: "antihypertensive agents" RELATED [ChEBI] +synonym: "antihypertensive drug" RELATED [ChEBI] +synonym: "antihypertensive drugs" RELATED [ChEBI] +xref: Wikipedia:Antihypertensive_drug +is_a: CHEBI:35554 ! cardiovascular drug + +[Term] +id: CHEBI:35676 +name: benzazepine +namespace: chebi_ontology +def: "A group of two-ring heterocyclic compounds consisting of a benzene ring fused to an azepine ring." [] +subset: 3_STAR +synonym: "benzazepine" EXACT [ChEBI] +synonym: "benzazepines" RELATED [ChEBI] +synonym: "benzoazepines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:35679 +name: antilipemic drug +namespace: chebi_ontology +def: "A substance used to treat hyperlipidemia (an excess of lipids in the blood)." [] +subset: 3_STAR +synonym: "antihyperlipemic" RELATED [ChEBI] +synonym: "antihyperlipemics" RELATED [ChEBI] +synonym: "antihyperlipidaemic agent" RELATED [ChEBI] +synonym: "antihyperlipidaemic agents" RELATED [ChEBI] +synonym: "antihyperlipidaemic drug" RELATED [ChEBI] +synonym: "antihyperlipidaemic drugs" RELATED [ChEBI] +synonym: "antihyperlipidemic" RELATED [ChEBI] +synonym: "antihyperlipidemic agent" RELATED [ChEBI] +synonym: "antihyperlipidemic agents" RELATED [ChEBI] +synonym: "antihyperlipidemic drug" RELATED [ChEBI] +synonym: "antihyperlipidemic drugs" RELATED [ChEBI] +synonym: "antihyperlipidemics" RELATED [ChEBI] +synonym: "antilipemic" RELATED [ChEBI] +synonym: "antilipemic drugs" RELATED [ChEBI] +synonym: "antilipemics" RELATED [ChEBI] +synonym: "hypolipidemic agent" RELATED [ChEBI] +synonym: "hypolipidemic agents" RELATED [ChEBI] +synonym: "lipid-lowering agent" RELATED [ChEBI] +synonym: "lipid-lowering agents" RELATED [ChEBI] +synonym: "lipid-lowering drug" RELATED [ChEBI] +synonym: "lipid-lowering drugs" RELATED [ChEBI] +xref: Wikipedia:Hypolipidemic_agent +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:35681 name: secondary alcohol @@ -13265,6 +21437,66 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "30.026" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.01056" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(*)O" xsd:string +[Term] +id: CHEBI:35688 +name: benzimidazolecarboxylic acid +namespace: chebi_ontology +def: "A member of the class of benzimidazoles carrying a carboxy group at unspecified position." [] +subset: 3_STAR +synonym: "benzimidazolecarboxylic acid" EXACT [ChEBI] +synonym: "benzimidazolecarboxylic acids" RELATED [ChEBI] +is_a: CHEBI:22715 ! benzimidazoles +is_a: CHEBI:25384 ! monocarboxylic acid + +[Term] +id: CHEBI:35689 +name: tetrazoles +namespace: chebi_ontology +def: "An azole in which the five-membered heterocyclic aromatic skeleton contains four N atoms and one C atom." [] +subset: 3_STAR +is_a: CHEBI:68452 ! azole + +[Term] +id: CHEBI:35690 +name: cyclobutane-1,1-dicarboxylate(2-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "cbdca" RELATED [IUPAC] +synonym: "cbdca(2-)" RELATED [ChEBI] +synonym: "cyclobutane-1,1-dicarboxylate" EXACT IUPAC_NAME [IUPAC] +xref: Gmelin:405673 {source="Gmelin"} +is_a: CHEBI:36205 ! cyclobutanedicarboxylate +relationship: is_conjugate_base_of CHEBI:35694 ! cyclobutane-1,1-dicarboxylate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8O4/c7-4(8)6(5(9)10)2-1-3-6/h1-3H2,(H,7,8)(H,9,10)/p-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CCQPAEQGAVNNIA-UHFFFAOYSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "142.10944" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "142.02771" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C1(CCC1)C([O-])=O" xsd:string + +[Term] +id: CHEBI:35691 +name: cyclobutane-1,1-dicarboxylic acid +namespace: chebi_ontology +subset: 3_STAR +synonym: "1,1-cyclobutanedicarboxylic acid" RELATED [ChemIDplus] +synonym: "cyclobutane-1,1-dicarboxylic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "H2cbdca" RELATED [IUPAC] +xref: Beilstein:2046031 {source="Beilstein"} +xref: CAS:5445-51-2 {source="ChemIDplus"} +xref: CAS:5445-51-2 {source="NIST Chemistry WebBook"} +xref: Gmelin:82590 {source="Gmelin"} +is_a: CHEBI:36186 ! cyclobutanedicarboxylic acid +relationship: is_conjugate_acid_of CHEBI:35694 ! cyclobutane-1,1-dicarboxylate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8O4/c7-4(8)6(5(9)10)2-1-3-6/h1-3H2,(H,7,8)(H,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CCQPAEQGAVNNIA-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "144.12532" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "144.04226" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1(CCC1)C(O)=O" xsd:string + [Term] id: CHEBI:35692 name: dicarboxylic acid @@ -13291,6 +21523,27 @@ synonym: "dicarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid +[Term] +id: CHEBI:35694 +name: cyclobutane-1,1-dicarboxylate(1-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "1-carboxycyclobutanecarboxylate" EXACT IUPAC_NAME [IUPAC] +synonym: "Hcbdca" RELATED [IUPAC] +synonym: "Hcbdca(-)" RELATED [ChEBI] +synonym: "hydrogen cyclobutane-1,1-dicarboxylate" RELATED [ChEBI] +xref: Gmelin:486356 {source="Gmelin"} +is_a: CHEBI:35695 ! dicarboxylic acid monoanion +relationship: is_conjugate_acid_of CHEBI:35690 ! cyclobutane-1,1-dicarboxylate(2-) +relationship: is_conjugate_base_of CHEBI:35691 ! cyclobutane-1,1-dicarboxylic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H7O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8O4/c7-4(8)6(5(9)10)2-1-3-6/h1-3H2,(H,7,8)(H,9,10)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CCQPAEQGAVNNIA-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "143.11738" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "143.03498" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)C1(CCC1)C([O-])=O" xsd:string + [Term] id: CHEBI:35695 name: dicarboxylic acid monoanion @@ -13330,6 +21583,51 @@ xref: KEGG:C06708 xref: Wikipedia:Xenobiotic is_a: CHEBI:24432 ! biological role +[Term] +id: CHEBI:35705 +name: immunosuppressive agent +namespace: chebi_ontology +def: "An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response." [] +subset: 3_STAR +synonym: "immunosuppressant" RELATED [ChEBI] +synonym: "immunosuppressive agents" RELATED [ChEBI] +synonym: "inmunosupresor" RELATED [ChEBI] +is_a: CHEBI:50846 ! immunomodulator + +[Term] +id: CHEBI:35715 +name: nitro compound +namespace: chebi_ontology +def: "A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied)." [] +subset: 3_STAR +synonym: "nitro compounds" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:51143 ! nitrogen molecular entity +relationship: has_part CHEBI:29785 ! nitro group + +[Term] +id: CHEBI:35716 +name: C-nitro compound +namespace: chebi_ontology +def: "A nitro compound having the nitro group (-NO2) attached to a carbon atom." [] +subset: 3_STAR +synonym: "C-nitro compounds" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35715 ! nitro compound +is_a: CHEBI:72695 ! organic molecule +relationship: is_tautomer_of CHEBI:136622 ! aci-nitro compound + +[Term] +id: CHEBI:35717 +name: sedative +namespace: chebi_ontology +def: "A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety." [] +subset: 3_STAR +synonym: "hypnotics" RELATED [ChEBI] +synonym: "hypnotics and sedatives" RELATED [ChEBI] +synonym: "sedative drug" RELATED [ChEBI] +synonym: "sedatives" RELATED [ChEBI] +synonym: "sedatives and hypnotics" RELATED [ChEBI] +is_a: CHEBI:35488 ! central nervous system depressant + [Term] id: CHEBI:35718 name: antifungal agent @@ -13365,6 +21663,44 @@ is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester is_a: CHEBI:63299 ! carbohydrate derivative +[Term] +id: CHEBI:35725 +name: isopropyl ester +namespace: chebi_ontology +def: "Any carboxylic ester resulting from the formal condensation of a carboxylic acid with the hydroxy group of propan-2-ol." [] +subset: 3_STAR +synonym: "propan-2-yl ester" RELATED [ChEBI] +synonym: "propan-2-yl esters" RELATED [ChEBI] +is_a: CHEBI:33308 ! carboxylic ester +relationship: has_functional_parent CHEBI:17824 ! propan-2-ol +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H7O2R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "87.097" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.04460" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(OC(C)C)(*)=O" xsd:string + +[Term] +id: CHEBI:35727 +name: triazoles +namespace: chebi_ontology +def: "An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms." [] +subset: 3_STAR +synonym: "triazole compounds" RELATED [ChEBI] +is_a: CHEBI:68452 ! azole + +[Term] +id: CHEBI:35735 +name: dicarboxylic acid monoamide +namespace: chebi_ontology +alt_id: CHEBI:13210 +alt_id: CHEBI:23691 +alt_id: CHEBI:6976 +subset: 3_STAR +synonym: "dicarboxylic acid monoamides" RELATED [ChEBI] +xref: KEGG:C04131 +is_a: CHEBI:23690 ! dicarboxylic acid amide +relationship: is_conjugate_acid_of CHEBI:77450 ! dicarboxylic acid monoamide(1-) + [Term] id: CHEBI:35740 name: liposaccharide @@ -13395,6 +21731,26 @@ synonym: "carbocyclic fatty acids" RELATED [ChEBI] is_a: CHEBI:59238 ! cyclic fatty acid relationship: is_conjugate_acid_of CHEBI:157668 ! carbocyclic fatty acid anion +[Term] +id: CHEBI:35748 +name: fatty acid ester +namespace: chebi_ontology +alt_id: CHEBI:27315 +alt_id: CHEBI:35747 +alt_id: CHEBI:78205 +def: "A carboxylic ester in which the carboxylic acid component can be any fatty acid." [] +subset: 3_STAR +synonym: "a fatty acid ester" RELATED [UniProt] +synonym: "FAEE" RELATED [SUBMITTER] +synonym: "fatty acid esters" RELATED [ChEBI] +is_a: CHEBI:33308 ! carboxylic ester +is_a: CHEBI:61697 ! fatty acid derivative +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OC([*])=O" xsd:string + [Term] id: CHEBI:35757 name: monocarboxylic acid anion @@ -13488,6 +21844,150 @@ synonym: "tetrapyrrole fundamental parents" RELATED [ChEBI] is_a: CHEBI:26932 ! tetrapyrrole is_a: CHEBI:35507 ! natural product fundamental parent +[Term] +id: CHEBI:35816 +name: leprostatic drug +namespace: chebi_ontology +def: "A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions." [] +subset: 3_STAR +synonym: "leprostatic" RELATED [ChEBI] +synonym: "leprostatic agent" RELATED [ChEBI] +synonym: "leprostatic drugs" RELATED [ChEBI] +is_a: CHEBI:64912 ! antimycobacterial drug + +[Term] +id: CHEBI:35819 +name: branched-chain fatty acid +namespace: chebi_ontology +alt_id: CHEBI:22919 +alt_id: CHEBI:3166 +def: "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." [] +subset: 3_STAR +synonym: "BCFA" RELATED [ChEBI] +synonym: "BCFAs" RELATED [ChEBI] +synonym: "Branched chain fatty acid" RELATED [KEGG_COMPOUND] +synonym: "branched fatty acid" RELATED [ChEBI] +synonym: "branched fatty acids" RELATED [ChEBI] +synonym: "branched-chain fatty acids" RELATED [ChEBI] +xref: KEGG:C05996 +xref: PMID:18318842 {source="Europe PMC"} +is_a: CHEBI:35366 ! fatty acid +relationship: is_conjugate_acid_of CHEBI:58955 ! branched-chain fatty acid anion + +[Term] +id: CHEBI:35820 +name: antiprotozoal drug +namespace: chebi_ontology +def: "Any antimicrobial drug which is used to treat or prevent protozoal infections." [] +subset: 3_STAR +synonym: "antiprotozoal agent" RELATED [ChEBI] +synonym: "antiprotozoal agents" RELATED [ChEBI] +synonym: "antiprotozoal drugs" RELATED [ChEBI] +xref: Wikipedia:Antiprotozoal_agent +is_a: CHEBI:35442 ! antiparasitic agent +is_a: CHEBI:36043 ! antimicrobial drug + +[Term] +id: CHEBI:35821 +name: anticholesteremic drug +namespace: chebi_ontology +alt_id: CHEBI:64906 +def: "A substance used to lower plasma cholesterol levels." [] +subset: 3_STAR +synonym: "anticholesteremic" RELATED [ChEBI] +synonym: "anticholesteremic agent" RELATED [ChEBI] +synonym: "anticholesteremic drugs" RELATED [ChEBI] +synonym: "antihypercholesterolemic" RELATED [ChEBI] +synonym: "antihypercholesterolemic agent" RELATED [ChEBI] +synonym: "antihypercholesterolemic agents" RELATED [ChEBI] +synonym: "antihypercholesterolemic drug" RELATED [ChEBI] +synonym: "antihypercholesterolemic drugs" RELATED [ChEBI] +synonym: "antihypercholesterolemics" RELATED [ChEBI] +synonym: "cholesterol inhibitor" RELATED [ChEBI] +synonym: "cholesterol-lowering agent" RELATED [ChEBI] +synonym: "cholesterol-lowering agents" RELATED [ChEBI] +synonym: "cholesterol-lowering drug" RELATED [ChEBI] +synonym: "cholesterol-lowering drugs" RELATED [ChEBI] +synonym: "hypocholesteremic agent" RELATED [ChEBI] +is_a: CHEBI:35679 ! antilipemic drug + +[Term] +id: CHEBI:35842 +name: antirheumatic drug +namespace: chebi_ontology +def: "A drug used to treat rheumatoid arthritis." [] +subset: 3_STAR +synonym: "anti-rheumatic drugs" RELATED [ChEBI] +synonym: "antirheumatic agent" RELATED [ChEBI] +synonym: "antirheumatic drugs" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:35845 +name: gout suppressant +namespace: chebi_ontology +def: "A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout." [] +subset: 3_STAR +synonym: "gout suppressants" RELATED [ChEBI] +is_a: CHEBI:35842 ! antirheumatic drug + +[Term] +id: CHEBI:35850 +name: sulfone +namespace: chebi_ontology +def: "An organosulfur compound having the structure RS(=O)2R (R =/= H)." [] +subset: 3_STAR +synonym: "sulfone" EXACT [ChEBI] +synonym: "sulfones" RELATED [ChEBI] +is_a: CHEBI:33261 ! organosulfur compound + +[Term] +id: CHEBI:35856 +name: lipoxygenase inhibitor +namespace: chebi_ontology +def: "A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes." [] +subset: 3_STAR +synonym: "lipooxygenase inhibitor" RELATED [ChEBI] +synonym: "lipoxygenase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76837 ! EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor + +[Term] +id: CHEBI:35857 +name: benzothiophene +namespace: chebi_ontology +subset: 3_STAR +synonym: "benzothiophene" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35570 ! mancude organic heterobicyclic parent +is_a: CHEBI:38767 ! benzothiophenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "134.200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.01902" xsd:string + +[Term] +id: CHEBI:35858 +name: 1-benzothiophene +namespace: chebi_ontology +subset: 3_STAR +synonym: "1-benzothiophene" EXACT IUPAC_NAME [IUPAC] +synonym: "1-thiaindene" RELATED [ChemIDplus] +synonym: "benzo[b]thiophene" RELATED [NIST_Chemistry_WebBook] +synonym: "benzothiofuran" RELATED [ChemIDplus] +synonym: "thianaphthene" RELATED [ChemIDplus] +xref: Beilstein:80580 {source="Beilstein"} +xref: CAS:95-15-8 {source="NIST Chemistry WebBook"} +xref: CAS:95-15-8 {source="ChemIDplus"} +xref: Gmelin:142782 {source="Gmelin"} +is_a: CHEBI:35857 ! benzothiophene +is_a: CHEBI:38836 ! 1-benzothiophenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6S/c1-2-4-8-7(3-1)5-6-9-8/h1-6H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FCEHBMOGCRZNNI-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "134.19924" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.01902" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ccc2sccc2c1" xsd:string + [Term] id: CHEBI:35868 name: hydroxy monocarboxylic acid @@ -13520,6 +22020,19 @@ synonym: "pnictogen hydrides" RELATED [ChEBI] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity +[Term] +id: CHEBI:35941 +name: serotonergic agonist +namespace: chebi_ontology +def: "An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders." [] +subset: 3_STAR +synonym: "5-HT agonist" RELATED [ChEBI] +synonym: "5-hydroxytryptamine agonist" RELATED [ChEBI] +synonym: "serotonergic agonists" RELATED [ChEBI] +synonym: "serotonin agonist" RELATED [ChEBI] +synonym: "serotonin agonists" RELATED [ChEBI] +is_a: CHEBI:48278 ! serotonergic drug + [Term] id: CHEBI:35942 name: neurotransmitter agent @@ -13545,6 +22058,15 @@ synonym: "beta-hydroxy carboxylic acids" RELATED [ChEBI] is_a: CHEBI:35868 ! hydroxy monocarboxylic acid is_a: CHEBI:61355 ! 3-hydroxy carboxylic acid +[Term] +id: CHEBI:35972 +name: dihydroxy monocarboxylic acid +namespace: chebi_ontology +def: "Any hydroxy monocarboxylic acid carrying at least two hydroxy groups." [] +subset: 3_STAR +synonym: "dihydroxy monocarboxylic acids" RELATED [ChEBI] +is_a: CHEBI:35868 ! hydroxy monocarboxylic acid + [Term] id: CHEBI:36009 name: omega-6 fatty acid @@ -13557,6 +22079,39 @@ xref: PMID:19035453 {source="Europe PMC"} xref: PMID:19136835 {source="Europe PMC"} is_a: CHEBI:59549 ! essential fatty acid +[Term] +id: CHEBI:36043 +name: antimicrobial drug +namespace: chebi_ontology +def: "A drug used to treat or prevent microbial infections." [] +subset: 3_STAR +synonym: "antimicrobial drugs" RELATED [ChEBI] +is_a: CHEBI:33281 ! antimicrobial agent +is_a: CHEBI:35441 ! antiinfective agent + +[Term] +id: CHEBI:36044 +name: antiviral drug +namespace: chebi_ontology +def: "A substance used in the prophylaxis or therapy of virus diseases." [] +subset: 3_STAR +synonym: "anti-viral drug" RELATED [ChEBI] +synonym: "anti-virus drug" RELATED [ChEBI] +synonym: "antiviral drugs" RELATED [ChEBI] +is_a: CHEBI:22587 ! antiviral agent +is_a: CHEBI:36043 ! antimicrobial drug + +[Term] +id: CHEBI:36047 +name: antibacterial drug +namespace: chebi_ontology +def: "A drug used to treat or prevent bacterial infections." [] +subset: 3_STAR +synonym: "antibacterial drugs" RELATED [ChEBI] +xref: Wikipedia:Antibacterial +is_a: CHEBI:33282 ! antibacterial agent +is_a: CHEBI:36043 ! antimicrobial drug + [Term] id: CHEBI:36054 name: benzoate ester @@ -13582,6 +22137,25 @@ synonym: "hydroxymonocarboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:35757 ! monocarboxylic acid anion relationship: is_conjugate_base_of CHEBI:35868 ! hydroxy monocarboxylic acid +[Term] +id: CHEBI:36064 +name: taxane +namespace: chebi_ontology +subset: 3_STAR +synonym: "(4R,4aR,6S,9R,10S,12aR)-tetradecahydro-4,9,12a,13,13-pentamethyl-6,10-methanobenzocyclodecene" RELATED [ChemIDplus] +synonym: "(4R-(4alpha,4abeta,6alpha,9alpha,10alpha,12aalpha))-tetradecahydro-4,9,12a,13,13-pentamethyl-6,10-methanobenzocyclodecene" RELATED [ChemIDplus] +synonym: "taxane" EXACT IUPAC_NAME [IUPAC] +xref: CAS:1605-68-1 {source="ChemIDplus"} +is_a: CHEBI:35190 ! diterpene +is_a: CHEBI:35662 ! terpenoid fundamental parent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H36" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H36/c1-14-7-6-11-20(5)12-10-17-15(2)8-9-16(13-18(14)20)19(17,3)4/h14-18H,6-13H2,1-5H3/t14-,15-,16+,17+,18-,20+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DKPFODGZWDEEBT-QFIAKTPHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "276.49984" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "276.28170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CC[C@@H](C)[C@]([H])(CC[C@]3(C)CCC[C@@H](C)[C@@]3([H])C1)C2(C)C" xsd:string + [Term] id: CHEBI:36078 name: cholanoid @@ -13607,6 +22181,30 @@ synonym: "proteins" EXACT IUPAC_NAME [IUPAC] is_a: PR:000000001 ! protein equivalent_to: PR:000000001 ! protein +[Term] +id: CHEBI:36093 +name: inorganic chloride +synonym: "inorganic chloride salt" RELATED [] +synonym: "inorganic chloride salts" RELATED [] +synonym: "inorganic chlorides" RELATED [] +is_a: CHEBI:23114 ! chloride salt +is_a: CHEBI:24839 ! inorganic salt + +[Term] +id: CHEBI:36141 +name: quinone +namespace: chebi_ontology +alt_id: CHEBI:13684 +alt_id: CHEBI:26517 +def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." [] +subset: 3_STAR +synonym: "Chinon" RELATED [ChEBI] +synonym: "quinone" EXACT [IUPAC] +synonym: "quinones" EXACT IUPAC_NAME [IUPAC] +synonym: "quinones" RELATED [ChEBI] +xref: Wikipedia:Quinone +is_a: CHEBI:3992 ! cyclic ketone + [Term] id: CHEBI:36180 name: butenedioate @@ -13626,6 +22224,24 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "114.05628" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "113.99641" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(=C([H])C([O-])=O)C([O-])=O" xsd:string +[Term] +id: CHEBI:36186 +name: cyclobutanedicarboxylic acid +namespace: chebi_ontology +subset: 3_STAR +synonym: "cyclobutanedicarboxylic acids" RELATED [ChEBI] +is_a: CHEBI:156473 ! cyclobutanes +is_a: CHEBI:35692 ! dicarboxylic acid + +[Term] +id: CHEBI:36205 +name: cyclobutanedicarboxylate +namespace: chebi_ontology +subset: 3_STAR +synonym: "cyclobutanedicarboxylates" RELATED [ChEBI] +is_a: CHEBI:156473 ! cyclobutanes +is_a: CHEBI:28965 ! dicarboxylic acid dianion + [Term] id: CHEBI:36233 name: disaccharide @@ -13643,6 +22259,88 @@ synonym: "Disacharid" RELATED [ChEBI] xref: KEGG:C01911 is_a: CHEBI:50699 ! oligosaccharide +[Term] +id: CHEBI:36235 +name: bile acid anion +namespace: chebi_ontology +subset: 3_STAR +synonym: "bile acid anions" RELATED [ChEBI] +is_a: CHEBI:35757 ! monocarboxylic acid anion +is_a: CHEBI:50160 ! steroid acid anion + +[Term] +id: CHEBI:36237 +name: cholanic acid +namespace: chebi_ontology +def: "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." [] +subset: 3_STAR +synonym: "cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] +xref: CAS:25312-65-6 {source="ChemIDplus"} +xref: Patent:JP2008069152 +xref: Reaxys:13246008 {source="Reaxys"} +is_a: CHEBI:36278 ! cholanic acids +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H40O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17?,18+,19-,20+,21+,23+,24-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RPKLZQLYODPWTM-KBMWBBLPSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "360.57320" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.30283" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O" xsd:string + +[Term] +id: CHEBI:36238 +name: 5beta-cholanic acid +namespace: chebi_ontology +subset: 3_STAR +synonym: "(5beta)-cholan-24-oic acid" RELATED [ChemIDplus] +synonym: "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" RELATED [ChemIDplus] +synonym: "5beta-cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "5beta-cholanic acid" EXACT [ChemIDplus] +synonym: "5beta-cholanoic acid" RELATED [ChemIDplus] +synonym: "ursocholanic acid" RELATED [ChemIDplus] +xref: Beilstein:3214794 {source="Beilstein"} +xref: CAS:546-18-9 {source="ChemIDplus"} +xref: LIPID_MAPS_instance:LMST04010441 {source="LIPID MAPS"} +is_a: CHEBI:36237 ! cholanic acid +is_a: CHEBI:36248 ! 5beta-cholanic acids +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H40O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RPKLZQLYODPWTM-LVVAJZGHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "360.57320" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.30283" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC(O)=O" xsd:string + +[Term] +id: CHEBI:36248 +name: 5beta-cholanic acids +namespace: chebi_ontology +def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." [] +subset: 3_STAR +is_a: CHEBI:136889 ! 5beta steroid +is_a: CHEBI:36278 ! cholanic acids +relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane + +[Term] +id: CHEBI:36277 +name: bile acid salt +namespace: chebi_ontology +def: "A salt of a bile acid." [] +subset: 3_STAR +synonym: "bile acid salts" RELATED [ChEBI] +is_a: CHEBI:24868 ! organic salt +is_a: CHEBI:36078 ! cholanoid + +[Term] +id: CHEBI:36278 +name: cholanic acids +namespace: chebi_ontology +alt_id: CHEBI:23166 +alt_id: CHEBI:23211 +subset: 1_STAR +is_a: CHEBI:36078 ! cholanoid +is_a: CHEBI:47891 ! steroid acid + [Term] id: CHEBI:36309 name: cyclic tetrapyrrole @@ -13654,6 +22352,17 @@ synonym: "macrocyclic tetrapyrroles" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:26932 ! tetrapyrrole is_a: CHEBI:47882 ! cyclic polypyrrole +[Term] +id: CHEBI:36326 +name: octadecanoid +namespace: chebi_ontology +def: "Unsaturated C18 fatty acids and skeletally related compounds." [] +subset: 3_STAR +synonym: "octadecanoids" RELATED [ChEBI] +is_a: CHEBI:15904 ! long-chain fatty acid +is_a: CHEBI:27208 ! unsaturated fatty acid +relationship: is_conjugate_acid_of CHEBI:131860 ! octadecanoid anion + [Term] id: CHEBI:36333 name: local anaesthetic @@ -13667,6 +22376,21 @@ synonym: "local anesthetics" RELATED [ChEBI] synonym: "Lokalanaesthetikum" RELATED [ChEBI] is_a: CHEBI:38867 ! anaesthetic +[Term] +id: CHEBI:36335 +name: trypanocidal drug +namespace: chebi_ontology +def: "A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida." [] +subset: 3_STAR +synonym: "antitrypanosomal agent" RELATED [ChEBI] +synonym: "antitrypanosomal agents" RELATED [ChEBI] +synonym: "antitrypanosomal drug" RELATED [ChEBI] +synonym: "antitrypanosomal drugs" RELATED [ChEBI] +synonym: "trypanocidal drugs" RELATED [ChEBI] +synonym: "trypanocide" RELATED [ChEBI] +synonym: "trypanosomicidal agents" RELATED [ChEBI] +is_a: CHEBI:35820 ! antiprotozoal drug + [Term] id: CHEBI:36338 name: lepton @@ -13715,6 +22439,7 @@ def: "A particle smaller than an atom." [] subset: 3_STAR synonym: "subatomic particles" RELATED [ChEBI] xref: Wikipedia:Subatomic_particle +is_a: BFO:0000040 ! material entity [Term] id: CHEBI:36343 @@ -13780,6 +22505,37 @@ namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:26082 ! phosphorus molecular entity +[Term] +id: CHEBI:36388 +name: saturated organic heterocyclic parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "saturated heterocyclic parent hydride" RELATED [ChEBI] +synonym: "saturated heterocyclic parent hydrides" RELATED [ChEBI] +synonym: "saturated organic heterocyclic parents" RELATED [ChEBI] +is_a: CHEBI:35552 ! heterocyclic organic fundamental parent + +[Term] +id: CHEBI:36389 +name: saturated organic heteromonocyclic parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "saturated heteromonocyclic parent hydride" RELATED [ChEBI] +synonym: "saturated heteromonocyclic parent hydrides" RELATED [ChEBI] +synonym: "saturated organic heteromonocyclic parents" RELATED [ChEBI] +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:36388 ! saturated organic heterocyclic parent + +[Term] +id: CHEBI:36416 +name: mancude organic heterotricyclic parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "mancude organic heterotricyclic parents" RELATED [ChEBI] +synonym: "mancude-ring organic heterotricyclic parents" RELATED [ChEBI] +is_a: CHEBI:26979 ! organic heterotricyclic compound +is_a: CHEBI:35571 ! mancude organic heterocyclic parent + [Term] id: CHEBI:36477 name: sulfoglycosphingolipid @@ -13820,6 +22576,41 @@ synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:72695 ! organic molecule relationship: has_part CHEBI:46629 ! oxo group +[Term] +id: CHEBI:36683 +name: organochlorine compound +namespace: chebi_ontology +def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." [] +subset: 3_STAR +synonym: "an organochlorine molecule" RELATED [UniProt] +synonym: "chloroorganic compounds" RELATED [ChEBI] +synonym: "chlororganische Verbindungen" RELATED [ChEBI] +synonym: "organochloride" RELATED [ChEBI] +synonym: "organochloride compound" RELATED [ChEBI] +synonym: "organochloride compounds" RELATED [ChEBI] +synonym: "organochlorides" RELATED [ChEBI] +synonym: "organochlorine compound" EXACT [ChEBI] +synonym: "organochlorine compounds" RELATED [ChEBI] +xref: MetaCyc:Chlorides +xref: Wikipedia:Organochloride +is_a: CHEBI:17792 ! organohalogen compound +is_a: CHEBI:23117 ! chlorine molecular entity +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "ClR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "35.453" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "34.96885" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*Cl" xsd:string + +[Term] +id: CHEBI:36688 +name: heterotricyclic compound +namespace: chebi_ontology +subset: 3_STAR +synonym: "heterotricyclic compound" EXACT [ChEBI] +synonym: "heterotricyclic compounds" EXACT IUPAC_NAME [IUPAC] +synonym: "heterotricyclic compounds" RELATED [ChEBI] +is_a: CHEBI:33671 ! heteropolycyclic compound + [Term] id: CHEBI:36699 name: corticosteroid hormone @@ -13845,6 +22636,17 @@ is_a: CHEBI:23217 ! cholines is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester +[Term] +id: CHEBI:36709 +name: aminoquinoline +namespace: chebi_ontology +def: "Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups." [] +subset: 3_STAR +synonym: "aminoquinoline" EXACT [ChEBI] +synonym: "aminoquinolines" RELATED [ChEBI] +is_a: CHEBI:26513 ! quinolines +is_a: CHEBI:33860 ! aromatic amine + [Term] id: CHEBI:36735 name: biladienes @@ -13853,6 +22655,155 @@ def: "Compounds based on a biladiene skeleton." [] subset: 3_STAR is_a: CHEBI:25046 ! linear tetrapyrrole +[Term] +id: CHEBI:36785 +name: carbobicyclic compound +namespace: chebi_ontology +def: "A bicyclic compound in which all the ring atoms are carbon." [] +subset: 3_STAR +synonym: "carbobicyclic compounds" RELATED [ChEBI] +is_a: CHEBI:33636 ! bicyclic compound +is_a: CHEBI:35294 ! carbopolycyclic compound + +[Term] +id: CHEBI:36791 +name: escitalopram +namespace: chebi_ontology +def: "A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram." [] +subset: 3_STAR +synonym: "(+)-citalopram" RELATED [ChEBI] +synonym: "(1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-citalopram" RELATED [ChemIDplus] +synonym: "escitalopram" RELATED INN [WHO_MedNet] +synonym: "escitalopramum" RELATED INN [WHO_MedNet] +synonym: "Esertia" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "S(+)-citalopram" RELATED [ChemIDplus] +synonym: "S-(+)-citalopram" RELATED [ChEBI] +xref: Beilstein:9001444 {source="Beilstein"} +xref: CAS:128196-01-0 {source="ChemIDplus"} +xref: Drug_Central:1053 {source="DrugCentral"} +xref: DrugBank:DB01175 +xref: HMDB:HMDB0005028 +xref: KEGG:D07913 +xref: LINCS:LSM-3569 +xref: PMID:14501259 {source="Europe PMC"} +xref: PMID:14594439 {source="Europe PMC"} +xref: PMID:14708881 {source="Europe PMC"} +xref: PMID:15200745 {source="Europe PMC"} +xref: PMID:15609164 {source="Europe PMC"} +xref: PMID:16266205 {source="Europe PMC"} +xref: PMID:16421462 {source="Europe PMC"} +xref: PMID:16937393 {source="Europe PMC"} +xref: PMID:16953656 {source="Europe PMC"} +xref: PMID:18789789 {source="Europe PMC"} +xref: PMID:19710642 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: PMID:24172161 {source="Europe PMC"} +xref: PMID:24176515 {source="Europe PMC"} +xref: PMID:24289655 {source="Europe PMC"} +xref: PMID:24424469 {source="Europe PMC"} +xref: PMID:24469525 {source="Europe PMC"} +xref: PMID:24528284 {source="Europe PMC"} +xref: Wikipedia:Escitalopram +is_a: CHEBI:77397 ! 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile +relationship: has_role CHEBI:35469 ! antidepressant +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +relationship: is_conjugate_base_of CHEBI:77406 ! escitalopram(1+) +relationship: is_enantiomer_of CHEBI:36792 ! (R)-citalopram +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-FQEVSTJZSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "324.39202" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "324.16379" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:36792 +name: (R)-citalopram +namespace: chebi_ontology +def: "A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has R-configuration at the chiral centre. It is the inactive enantiomer of citalopram." [] +subset: 3_STAR +synonym: "(-)-citalopram" RELATED [ChEBI] +synonym: "(1R)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile" RELATED [ChEBI] +synonym: "(R)-(-)-citalopram" RELATED [ChEBI] +xref: Beilstein:9001443 {source="Beilstein"} +xref: PMID:14501259 {source="Europe PMC"} +xref: Reaxys:9001443 {source="Reaxys"} +is_a: CHEBI:77397 ! 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile +relationship: is_conjugate_base_of CHEBI:77405 ! (R)-citalopram(1+) +relationship: is_enantiomer_of CHEBI:36791 ! escitalopram +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-HXUWFJFHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "324.39202" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "324.16379" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)CCC[C@@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:36796 +name: duloxetine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine" RELATED [IUPAC] +synonym: "N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:8842375 {source="Beilstein"} +xref: CAS:116539-58-3 {source="ChemIDplus"} +xref: PMID:20825390 {source="Europe PMC"} +is_a: CHEBI:26961 ! thiophenes +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H19NOS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZEUITGRIYCTCEM-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "297.41560" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "297.11874" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CNCCC(Oc1cccc2ccccc12)c1cccs1" xsd:string + +[Term] +id: CHEBI:36820 +name: ring assembly +namespace: chebi_ontology +def: "Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved." [] +subset: 3_STAR +synonym: "ring assemblies" EXACT IUPAC_NAME [IUPAC] +synonym: "ring assembly" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:33595 ! cyclic compound + +[Term] +id: CHEBI:36823 +name: pseudohalo group +namespace: chebi_ontology +subset: 3_STAR +synonym: "halogenoid group" RELATED [ChEBI] +synonym: "pseudohalide group" EXACT IUPAC_NAME [IUPAC] +synonym: "pseudohalido group" RELATED [ChEBI] +synonym: "pseudohalo groups" RELATED [ChEBI] +synonym: "pseudohalogen group" RELATED [IUPAC] +is_a: CHEBI:24433 ! group + +[Term] +id: CHEBI:36828 +name: pseudohalide anion +namespace: chebi_ontology +subset: 3_STAR +synonym: "pseudohalide anions" RELATED [ChEBI] +synonym: "pseudohalide ions" EXACT IUPAC_NAME [IUPAC] +synonym: "pseudohalides" RELATED [ChEBI] +synonym: "pseudohalogen anion" RELATED [ChEBI] +synonym: "pseudohalogen ion" RELATED [ChEBI] +is_a: CHEBI:36829 ! polyatomic monoanion + +[Term] +id: CHEBI:36829 +name: polyatomic monoanion +namespace: chebi_ontology +subset: 3_STAR +synonym: "polyatomic monoanions" RELATED [ChEBI] +is_a: CHEBI:33273 ! polyatomic anion +is_a: CHEBI:36830 ! monoanion + [Term] id: CHEBI:36830 name: monoanion @@ -13901,6 +22852,15 @@ subset: 3_STAR synonym: "17-hydroxy steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid +[Term] +id: CHEBI:36840 +name: 16-hydroxy steroid +namespace: chebi_ontology +def: "Any hydroxy steroid carrying a hydroxy group at position 16." [] +subset: 3_STAR +synonym: "16-hydroxy steroids" RELATED [ChEBI] +is_a: CHEBI:35350 ! hydroxy steroid + [Term] id: CHEBI:36841 name: 11-hydroxy steroid @@ -13918,6 +22878,31 @@ synonym: "hydroxy seco-steroids" RELATED [ChEBI] is_a: CHEBI:35350 ! hydroxy steroid is_a: CHEBI:35788 ! seco-steroid +[Term] +id: CHEBI:36856 +name: hydrogen isocyanide +namespace: chebi_ontology +subset: 3_STAR +synonym: "CNH" RELATED [ChEBI] +synonym: "HN(+)#C(-)" RELATED [IUPAC] +synonym: "HNC" RELATED [NIST_Chemistry_WebBook] +synonym: "hydrogen isocyanide" EXACT [NIST_Chemistry_WebBook] +synonym: "hydroisocyanic acid" RELATED [ChEBI] +synonym: "nitriliomethanide" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:2069401 {source="Beilstein"} +xref: CAS:6914-07-4 {source="NIST Chemistry WebBook"} +xref: Gmelin:113 {source="Gmelin"} +is_a: CHEBI:33405 ! hydracid +relationship: is_conjugate_acid_of CHEBI:17514 ! cyanide +relationship: is_tautomer_of CHEBI:18407 ! hydrogen cyanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CHN/c1-2/h2H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QIUBLANJVAOHHY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "27.02538" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.01090" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C-]#[NH+]" xsd:string + [Term] id: CHEBI:36885 name: 20-oxo steroid @@ -14027,6 +23012,47 @@ is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound relationship: is_conjugate_base_of CHEBI:33709 ! amino acid +[Term] +id: CHEBI:37070 +name: 2-methylbutyric acid +namespace: chebi_ontology +def: "A methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria." [] +subset: 3_STAR +synonym: "2-methybutyric acid" RELATED [ChemIDplus] +synonym: "2-methylbutanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "2-Methylbutyric acid" EXACT [KEGG_COMPOUND] +synonym: "2-methylbutyric acid" EXACT [NIST_Chemistry_WebBook] +synonym: "alpha-methyl butyric acid" RELATED [LIPID_MAPS] +synonym: "alpha-methylbutyric acid" RELATED [NIST_Chemistry_WebBook] +synonym: "butane-2-carboxylic acid" RELATED [ChEBI] +synonym: "ethylmethylacetic acid" RELATED [ChemIDplus] +synonym: "methylethylacetic acid" RELATED [ChemIDplus] +xref: Beilstein:1098537 {source="Beilstein"} +xref: CAS:116-53-0 {source="KEGG COMPOUND"} +xref: CAS:116-53-0 {source="ChemIDplus"} +xref: CAS:116-53-0 {source="NIST Chemistry WebBook"} +xref: DrugBank:DB03741 +xref: HMDB:HMDB0002176 +xref: KEGG:C18319 +xref: LIPID_MAPS_instance:LMFA01020072 {source="LIPID MAPS"} +xref: PMID:15615815 {source="Europe PMC"} +xref: PMID:16751541 {source="Europe PMC"} +xref: PMID:18828792 {source="Europe PMC"} +xref: PMID:22202876 {source="Europe PMC"} +xref: PMID:3372640 {source="Europe PMC"} +xref: Reaxys:1098537 {source="Reaxys"} +is_a: CHEBI:38653 ! methylbutyric acid +relationship: has_role CHEBI:76969 ! bacterial metabolite +relationship: has_role CHEBI:77746 ! human metabolite +relationship: is_conjugate_acid_of CHEBI:48946 ! 2-methylbutyrate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLAMNBDJUVNPJU-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "102.13170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)C(O)=O" xsd:string + [Term] id: CHEBI:37142 name: organoiodine compound @@ -14045,6 +23071,129 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "126.904" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "126.90447" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*I" xsd:string +[Term] +id: CHEBI:37143 +name: organofluorine compound +namespace: chebi_ontology +def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." [] +subset: 3_STAR +synonym: "fluoroorganic compound" RELATED [ChEBI] +synonym: "fluoroorganic compounds" RELATED [ChEBI] +synonym: "fluoroorganics" RELATED [ChEBI] +synonym: "fluororganische Verbindungen" RELATED [ChEBI] +synonym: "organofluorine compound" EXACT [ChEBI] +synonym: "organofluorine compounds" RELATED [ChEBI] +xref: MetaCyc:Fluorides +is_a: CHEBI:17792 ! organohalogen compound +is_a: CHEBI:24062 ! fluorine molecular entity +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "FR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "18.998" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.99840" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "*F" xsd:string + +[Term] +id: CHEBI:37153 +name: EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:62670 +def: "Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16)." [] +subset: 3_STAR +synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitor" RELATED [ChEBI] +synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase inhibitors" RELATED [ChEBI] +synonym: "Aspergillus awamori acid protein phosphatase inhibitor" RELATED [ChEBI] +synonym: "Aspergillus awamori acid protein phosphatase inhibitors" RELATED [ChEBI] +synonym: "BCKDH phosphatase inhibitor" RELATED [ChEBI] +synonym: "BCKDH phosphatase inhibitors" RELATED [ChEBI] +synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitor" RELATED [ChEBI] +synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase inhibitors" RELATED [ChEBI] +synonym: "calcineurin inhibitor" RELATED [ChEBI] +synonym: "calcineurin inhibitors" RELATED [ChEBI] +synonym: "casein phosphatase inhibitor" RELATED [ChEBI] +synonym: "casein phosphatase inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.3.16 (protein serine/threonine phosphatase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.3.16 inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.3.16 inhibitors" RELATED [ChEBI] +synonym: "HMG-CoA reductase phosphatase inhibitor" RELATED [ChEBI] +synonym: "HMG-CoA reductase phosphatase inhibitors" RELATED [ChEBI] +synonym: "phosphatase 2A inhibitor" RELATED [ChEBI] +synonym: "phosphatase 2A inhibitors" RELATED [ChEBI] +synonym: "phosphatase 2B inhibitor" RELATED [ChEBI] +synonym: "phosphatase 2B inhibitors" RELATED [ChEBI] +synonym: "phosphatase C-II inhibitor" RELATED [ChEBI] +synonym: "phosphatase C-II inhibitors" RELATED [ChEBI] +synonym: "phosphatase H-II inhibitor" RELATED [ChEBI] +synonym: "phosphatase H-II inhibitors" RELATED [ChEBI] +synonym: "phosphatase I inhibitor" RELATED [ChEBI] +synonym: "phosphatase I inhibitors" RELATED [ChEBI] +synonym: "phosphatase IB inhibitor" RELATED [ChEBI] +synonym: "phosphatase IB inhibitors" RELATED [ChEBI] +synonym: "phosphatase II inhibitor" RELATED [ChEBI] +synonym: "phosphatase II inhibitors" RELATED [ChEBI] +synonym: "phosphatase III inhibitor" RELATED [ChEBI] +synonym: "phosphatase III inhibitors" RELATED [ChEBI] +synonym: "phosphatase IV inhibitor" RELATED [ChEBI] +synonym: "phosphatase IV inhibitors" RELATED [ChEBI] +synonym: "phosphatase SP inhibitor" RELATED [ChEBI] +synonym: "phosphatase SP inhibitors" RELATED [ChEBI] +synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitor" RELATED [ChEBI] +synonym: "phosphoprotein phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] +synonym: "phosphoprotein phosphatase inhibitor" RELATED [ChEBI] +synonym: "phosphoprotein phosphatase inhibitors" RELATED [ChEBI] +synonym: "phosphoprotein phosphohydrolase inhibitor" RELATED [ChEBI] +synonym: "phosphoprotein phosphohydrolase inhibitors" RELATED [ChEBI] +synonym: "phosphopyruvate dehydrogenase phosphatase inhibitor" RELATED [ChEBI] +synonym: "phosphopyruvate dehydrogenase phosphatase inhibitors" RELATED [ChEBI] +synonym: "phosphospectrin phosphatase inhibitor" RELATED [ChEBI] +synonym: "phosphospectrin phosphatase inhibitors" RELATED [ChEBI] +synonym: "polycation modulated (PCM-) phosphatase inhibitor" RELATED [ChEBI] +synonym: "polycation modulated (PCM-) phosphatase inhibitors" RELATED [ChEBI] +synonym: "protein D phosphatase inhibitor" RELATED [ChEBI] +synonym: "protein D phosphatase inhibitors" RELATED [ChEBI] +synonym: "protein phosphatase inhibitor" RELATED [ChEBI] +synonym: "protein phosphatase inhibitors" RELATED [ChEBI] +synonym: "protein phosphatase-1 inhibitor" RELATED [ChEBI] +synonym: "protein phosphatase-1 inhibitors" RELATED [ChEBI] +synonym: "protein phosphatase-2A inhibitor" RELATED [ChEBI] +synonym: "protein phosphatase-2A inhibitors" RELATED [ChEBI] +synonym: "protein phosphatase-2B inhibitor" RELATED [ChEBI] +synonym: "protein phosphatase-2B inhibitors" RELATED [ChEBI] +synonym: "protein phosphatase-2C inhibitor" RELATED [ChEBI] +synonym: "protein phosphatase-2C inhibitors" RELATED [ChEBI] +synonym: "protein serine/threonine phosphatase (EC 3.1.3.16) inhibitors" RELATED [ChEBI] +synonym: "protein serine/threonine phosphatase inhibitor" RELATED [ChEBI] +synonym: "protein serine/threonine phosphatase inhibitors" RELATED [ChEBI] +synonym: "serine/threonine specific protein phosphatase inhibitor" RELATED [ChEBI] +synonym: "serine/threonine specific protein phosphatase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Phosphoprotein_phosphatase +xref: Wikipedia:Protein_serine/threonine_phosphatase +is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor + +[Term] +id: CHEBI:37154 +name: fumarate(1-) +namespace: chebi_ontology +def: "A hydrogen butenedioate obtained by deprotonation of one of the carboxy groups of fumaric acid." [] +subset: 3_STAR +synonym: "(2E)-3-carboxyacrylate" RELATED [IUPAC] +synonym: "(2E)-3-carboxyprop-2-enoate" EXACT IUPAC_NAME [IUPAC] +synonym: "fumarate monoanion" RELATED [ChEBI] +synonym: "hydrogen fumarate" RELATED [ChEBI] +xref: Beilstein:1906438 {source="Beilstein"} +xref: Gmelin:325290 {source="Gmelin"} +xref: Reaxys:1906438 {source="Reaxys"} +is_a: CHEBI:37155 ! hydrogen butenedioate +relationship: has_role CHEBI:78675 ! fundamental metabolite +relationship: is_conjugate_acid_of CHEBI:29806 ! fumarate(2-) +relationship: is_conjugate_base_of CHEBI:18012 ! fumaric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H3O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/p-1/b2-1+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VZCYOOQTPOCHFL-OWOJBTEDSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "115.06422" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "115.00368" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)\\C=C\\C([O-])=O" xsd:string + [Term] id: CHEBI:37155 name: hydrogen butenedioate @@ -14134,6 +23283,56 @@ synonym: "mononuclear hydrides" RELATED [IUPAC] synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC] is_a: CHEBI:33692 ! hydrides +[Term] +id: CHEBI:3723 +name: citalopram +namespace: chebi_ontology +def: "A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active." [] +subset: 3_STAR +synonym: "1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile" RELATED [ChemIDplus] +synonym: "1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile" RELATED [ChemIDplus] +synonym: "Cipram" RELATED BRAND_NAME [ChemIDplus] +synonym: "Citadur" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Citalopram" EXACT [KEGG_COMPOUND] +synonym: "citalopram" RELATED INN [WHO_MedNet] +synonym: "citalopram" RELATED INN [ChemIDplus] +synonym: "citalopramum" RELATED INN [ChemIDplus] +synonym: "Lu 10-171" RELATED [ChemIDplus] +synonym: "Nitalapram" RELATED [ChemIDplus] +synonym: "rac-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1397373 {source="Beilstein"} +xref: CAS:59729-33-8 {source="KEGG COMPOUND"} +xref: CAS:59729-33-8 {source="NIST Chemistry WebBook"} +xref: CAS:59729-33-8 {source="ChemIDplus"} +xref: DrugBank:DB00215 +xref: HMDB:HMDB0005038 +xref: KEGG:C07572 +xref: KEGG:D07704 +xref: Patent:DE2657013 +xref: Patent:EP0171943 +xref: Patent:EP1506963 +xref: Patent:US4136193 +xref: PMID:11336616 {source="Europe PMC"} +xref: PMID:18213744 {source="Europe PMC"} +xref: PMID:18219053 {source="Europe PMC"} +xref: PMID:19747949 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: Reaxys:1397373 {source="Reaxys"} +xref: Wikipedia:Citalopram +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:36791 ! escitalopram +relationship: has_part CHEBI:36792 ! (R)-citalopram +relationship: has_role CHEBI:35469 ! antidepressant +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:50949 ! serotonin uptake inhibitor +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +relationship: has_role CHEBI:77402 ! EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "324.393" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "324.16379" xsd:string + [Term] id: CHEBI:37246 name: elemental sodium @@ -14176,6 +23375,20 @@ synonym: "Mukopolysaccharid" RELATED [ChEBI] xref: KEGG:C05114 is_a: CHEBI:18085 ! glycosaminoglycan +[Term] +id: CHEBI:37397 +name: chondroitin sulfate +def: "Any of a class of 10--60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues." [] +synonym: "chondroitin polysulfate" RELATED [] +synonym: "Chondroitin sulfate" EXACT [] +synonym: "chondroitin sulfates" RELATED [] +synonym: "chondroitin sulfuric acid" RELATED [] +synonym: "chondroitin sulphate" RELATED [] +synonym: "Chondroitinsulfat" RELATED [] +is_a: CHEBI:35722 ! sulfated glycosaminoglycan +is_a: CHEBI:37395 ! mucopolysaccharide +relationship: has_functional_parent CHEBI:16137 ! chondroitin D-glucuronate + [Term] id: CHEBI:37404 name: elemental copper @@ -14183,6 +23396,84 @@ namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:23377 ! copper molecular entity +[Term] +id: CHEBI:37407 +name: cyclic ether +namespace: chebi_ontology +alt_id: CHEBI:37406 +def: "Any ether in which the oxygen atom forms part of a ring." [] +subset: 3_STAR +synonym: "cyclic ether" EXACT [IUPAC] +synonym: "cyclic ethers" EXACT IUPAC_NAME [IUPAC] +synonym: "cyclic ethers" RELATED [ChEBI] +synonym: "epoxy compounds" EXACT IUPAC_NAME [IUPAC] +synonym: "epoxy compounds" RELATED [ChEBI] +is_a: CHEBI:25698 ! ether +is_a: CHEBI:38104 ! oxacycle + +[Term] +id: CHEBI:37416 +name: EC 2.7.7.6 (RNA polymerase) inhibitor +namespace: chebi_ontology +def: "An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6)." [] +subset: 3_STAR +synonym: "C ribonucleic acid formation factors inhibitor" RELATED [ChEBI] +synonym: "C ribonucleic acid formation factors inhibitors" RELATED [ChEBI] +synonym: "C RNA formation factors inhibitor" RELATED [ChEBI] +synonym: "C RNA formation factors inhibitors" RELATED [ChEBI] +synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitor" RELATED [ChEBI] +synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase inhibitors" RELATED [ChEBI] +synonym: "directed RNA polymerase inhibitor" RELATED [ChEBI] +synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "DNA-dependent ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "DNA-dependent RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "DNA-dependent RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "DNA-dependent RNA polymerase inhibitor" RELATED [ChEBI] +synonym: "DNA-dependent RNA polymerase inhibitors" RELATED [ChEBI] +synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "DNA-directed nucleoside-triphosphate:RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "DNA-directed RNA polymerase inhibitor" RELATED [ChEBI] +synonym: "DNA-directed RNA polymerase inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.7.6 (RNA polymerase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.7.6 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.7.6 inhibitors" RELATED [ChEBI] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] +synonym: "ribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "ribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "ribonucleate polymerase inhibitor" RELATED [ChEBI] +synonym: "ribonucleate polymerase inhibitors" RELATED [ChEBI] +synonym: "ribonucleic acid nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "ribonucleic acid nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "ribonucleic acid polymerase inhibitor" RELATED [ChEBI] +synonym: "ribonucleic acid polymerase inhibitors" RELATED [ChEBI] +synonym: "ribonucleic acid transcriptase inhibitor" RELATED [ChEBI] +synonym: "ribonucleic acid transcriptase inhibitors" RELATED [ChEBI] +synonym: "ribonucleic polymerase inhibitor" RELATED [ChEBI] +synonym: "ribonucleic polymerase inhibitors" RELATED [ChEBI] +synonym: "ribonucleic transcriptase inhibitor" RELATED [ChEBI] +synonym: "ribonucleic transcriptase inhibitors" RELATED [ChEBI] +synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitor" RELATED [ChEBI] +synonym: "RNA nucleotidyltransferase (DNA-directed) inhibitors" RELATED [ChEBI] +synonym: "RNA nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "RNA nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "RNA polymerase (EC 2.7.7.6) inhibitor" RELATED [ChEBI] +synonym: "RNA polymerase (EC 2.7.7.6) inhibitors" RELATED [ChEBI] +synonym: "RNA polymerase I inhibitor" RELATED [ChEBI] +synonym: "RNA polymerase I inhibitors" RELATED [ChEBI] +synonym: "RNA polymerase II inhibitor" RELATED [ChEBI] +synonym: "RNA polymerase II inhibitors" RELATED [ChEBI] +synonym: "RNA polymerase III inhibitor" RELATED [ChEBI] +synonym: "RNA polymerase III inhibitors" RELATED [ChEBI] +synonym: "RNA polymerase inhibitor" RELATED [ChEBI] +synonym: "RNA polymerase inhibitors" RELATED [ChEBI] +synonym: "RNA transcriptase inhibitor" RELATED [ChEBI] +synonym: "RNA transcriptase inhibitors" RELATED [ChEBI] +synonym: "transcriptase inhibitor" RELATED [ChEBI] +synonym: "transcriptase inhibitors" RELATED [ChEBI] +xref: Wikipedia:RNA_polymerase +is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor + [Term] id: CHEBI:37445 name: folic acids @@ -14219,6 +23510,18 @@ synonym: "Saeuren" RELATED [ChEBI] xref: KEGG:C00174 is_a: CHEBI:51086 ! chemical role +[Term] +id: CHEBI:37533 +name: azo compound +namespace: chebi_ontology +def: "Derivatives of diazene with the general structure R-N=N-R'." [] +subset: 3_STAR +synonym: "azo compounds" EXACT IUPAC_NAME [IUPAC] +synonym: "azo compounds" RELATED [ChEBI] +is_a: CHEBI:51143 ! nitrogen molecular entity +relationship: has_parent_hydride CHEBI:30096 ! diazene +relationship: has_part CHEBI:30106 ! azo group + [Term] id: CHEBI:37577 name: heteroatomic molecular entity @@ -14266,6 +23569,20 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "83.066" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "83.01330" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O1C(C(C(C1=O)*)*)*" xsd:string +[Term] +id: CHEBI:37598 +name: nitrogen mustard +namespace: chebi_ontology +def: "Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR." [] +subset: 3_STAR +synonym: "nitrogen mustard compound" RELATED [ChEBI] +synonym: "nitrogen mustard compounds" RELATED [ChEBI] +synonym: "nitrogen mustards" EXACT IUPAC_NAME [IUPAC] +synonym: "nitrogen mustards" RELATED [ChEBI] +xref: Wikipedia:Nitrogen_mustard +is_a: CHEBI:35352 ! organonitrogen compound +relationship: has_role CHEBI:22333 ! alkylating agent + [Term] id: CHEBI:37622 name: carboxamide @@ -14287,6 +23604,210 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)N([*])[*]" xsd:string +[Term] +id: CHEBI:37624 +name: L-glucose +namespace: chebi_ontology +subset: 3_STAR +synonym: "L(-)-glucose" RELATED [ChemIDplus] +synonym: "L-gluco-hexose" EXACT IUPAC_NAME [IUPAC] +synonym: "L-glucose" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1724626 {source="ChemIDplus"} +xref: CAS:921-60-8 {source="ChemIDplus"} +is_a: CHEBI:17234 ! glucose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string + +[Term] +id: CHEBI:37627 +name: L-glucopyranose +namespace: chebi_ontology +def: "The L-enantiomer of glucopyranose." [] +subset: 3_STAR +synonym: "L-glucopyranose" EXACT IUPAC_NAME [IUPAC] +synonym: "WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/" RELATED [GlyTouCan] +xref: Beilstein:2206321 {source="Beilstein"} +xref: GlyGen:G16038XU +xref: GlyTouCan:G16038XU +xref: Reaxys:2206321 {source="Reaxys"} +is_a: CHEBI:37624 ! L-glucose +is_a: CHEBI:37661 ! glucopyranose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-ZZWDRFIYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@H]1O" xsd:string + +[Term] +id: CHEBI:37631 +name: beta-L-glucose +namespace: chebi_ontology +def: "A L-glucopyranose with a beta-configuration at the anomeric position." [] +subset: 3_STAR +synonym: "beta-L-glucopyranose" EXACT IUPAC_NAME [IUPAC] +synonym: "WURCS=2.0/1,1,0/[a1211h-1b_1-5]/1/" RELATED [GlyTouCan] +xref: Beilstein:1907373 {source="Beilstein"} +xref: GlyGen:G59396XU +xref: GlyTouCan:G59396XU +xref: Reaxys:1907373 {source="Reaxys"} +is_a: CHEBI:37627 ! L-glucopyranose +relationship: is_enantiomer_of CHEBI:15903 ! beta-D-glucose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-QYESYBIKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@@H]1O[C@H](O)[C@@H](O)[C@H](O)[C@H]1O" xsd:string + +[Term] +id: CHEBI:3766 +name: clozapine +namespace: chebi_ontology +def: "A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia." [] +subset: 3_STAR +synonym: "8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine" EXACT IUPAC_NAME [IUPAC] +synonym: "Clozapin" RELATED [DrugBank] +synonym: "clozapina" RELATED INN [ChEBI] +synonym: "Clozapine" EXACT [KEGG_COMPOUND] +synonym: "clozapine" RELATED INN [ChEBI] +synonym: "clozapinum" RELATED INN [ChEBI] +xref: Beilstein:0764984 {source="Beilstein"} +xref: CAS:5786-21-0 {source="ChemIDplus"} +xref: Drug_Central:722 {source="DrugCentral"} +xref: DrugBank:DB00363 +xref: HMDB:HMDB0014507 +xref: KEGG:C06924 +xref: KEGG:D00283 +xref: Patent:FR1334944 +xref: Patent:NL293201 +xref: Patent:US3539573 +xref: PMID:18690109 {source="Europe PMC"} +xref: PMID:18766167 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: PMID:24219174 {source="Europe PMC"} +xref: Reaxys:764984 {source="Reaxys"} +xref: Wikipedia:Clozapine +is_a: CHEBI:22720 ! benzodiazepine +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:46848 ! N-arylpiperazine +is_a: CHEBI:46920 ! N-methylpiperazine +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:37887 ! adrenergic antagonist +relationship: has_role CHEBI:37956 ! histamine antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:48876 ! muscarinic antagonist +relationship: has_role CHEBI:65191 ! second generation antipsychotic +relationship: has_role CHEBI:65259 ! GABA antagonist +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H19ClN4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QZUDBNBUXVUHMW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "326.824" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "326.12982" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1=C(C2=CC=CC=C2NC3=CC=C(C=C13)Cl)N4CCN(CC4)C" xsd:string + +[Term] +id: CHEBI:37661 +name: glucopyranose +namespace: chebi_ontology +subset: 3_STAR +synonym: "glucopyranose" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:17234 ! glucose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string + +[Term] +id: CHEBI:37670 +name: protease inhibitor +namespace: chebi_ontology +def: "A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases)." [] +subset: 3_STAR +synonym: "protease inhibitors" RELATED [ChEBI] +xref: Wikipedia:Protease_inhibitor_(biology) +is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor + +[Term] +id: CHEBI:37699 +name: protein kinase inhibitor +namespace: chebi_ontology +def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases." [] +subset: 3_STAR +synonym: "protein kinase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor + +[Term] +id: CHEBI:37700 +name: EC 2.7.11.13 (protein kinase C) inhibitor +namespace: chebi_ontology +def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13)." [] +subset: 3_STAR +synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitor" RELATED [ChEBI] +synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) inhibitors" RELATED [ChEBI] +synonym: "calcium-dependent protein kinase C inhibitor" RELATED [ChEBI] +synonym: "calcium-dependent protein kinase C inhibitors" RELATED [ChEBI] +synonym: "calcium-independent protein kinase C inhibitor" RELATED [ChEBI] +synonym: "calcium-independent protein kinase C inhibitors" RELATED [ChEBI] +synonym: "calcium/phospholipid dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "calcium/phospholipid dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "cPKC inhibitor" RELATED [ChEBI] +synonym: "cPKC inhibitors" RELATED [ChEBI] +synonym: "cPKCalpha inhibitor" RELATED [ChEBI] +synonym: "cPKCalpha inhibitors" RELATED [ChEBI] +synonym: "cPKCbeta inhibitor" RELATED [ChEBI] +synonym: "cPKCbeta inhibitors" RELATED [ChEBI] +synonym: "cPKCgamma inhibitor" RELATED [ChEBI] +synonym: "cPKCgamma inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.13 (protein kinase C) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.13 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.11.13 inhibitors" RELATED [ChEBI] +synonym: "nPKC inhibitor" RELATED [ChEBI] +synonym: "nPKC inhibitors" RELATED [ChEBI] +synonym: "nPKCdelta inhibitor" RELATED [ChEBI] +synonym: "nPKCdelta inhibitors" RELATED [ChEBI] +synonym: "nPKCepsilon inhibitor" RELATED [ChEBI] +synonym: "nPKCepsilon inhibitors" RELATED [ChEBI] +synonym: "nPKCeta inhibitor" RELATED [ChEBI] +synonym: "nPKCeta inhibitors" RELATED [ChEBI] +synonym: "nPKCtheta inhibitor" RELATED [ChEBI] +synonym: "nPKCtheta inhibitors" RELATED [ChEBI] +synonym: "PKC inhibitor" RELATED [ChEBI] +synonym: "PKC inhibitors" RELATED [ChEBI] +synonym: "Pkc1p inhibitor" RELATED [ChEBI] +synonym: "Pkc1p inhibitors" RELATED [ChEBI] +synonym: "PKCalpha inhibitor" RELATED [ChEBI] +synonym: "PKCalpha inhibitors" RELATED [ChEBI] +synonym: "PKCbeta inhibitor" RELATED [ChEBI] +synonym: "PKCbeta inhibitors" RELATED [ChEBI] +synonym: "PKCdelta inhibitor" RELATED [ChEBI] +synonym: "PKCdelta inhibitors" RELATED [ChEBI] +synonym: "PKCepsilon inhibitor" RELATED [ChEBI] +synonym: "PKCepsilon inhibitors" RELATED [ChEBI] +synonym: "PKCgamma inhibitor" RELATED [ChEBI] +synonym: "PKCgamma inhibitors" RELATED [ChEBI] +synonym: "PKCzeta inhibitor" RELATED [ChEBI] +synonym: "PKCzeta inhibitors" RELATED [ChEBI] +synonym: "PKN3 inhibitor" RELATED [ChEBI] +synonym: "PKN3 inhibitors" RELATED [ChEBI] +synonym: "protein kinase C (EC 2.7.11.13) inhibitor" RELATED [ChEBI] +synonym: "protein kinase C (EC 2.7.11.13) inhibitors" RELATED [ChEBI] +synonym: "protein kinase C inhibitor" RELATED [ChEBI] +synonym: "protein kinase C inhibitors" RELATED [ChEBI] +synonym: "protein kinase Cepsilon inhibitor" RELATED [ChEBI] +synonym: "protein kinase Cepsilon inhibitors" RELATED [ChEBI] +synonym: "STK24 inhibitor" RELATED [ChEBI] +synonym: "STK24 inhibitors" RELATED [ChEBI] +is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor + [Term] id: CHEBI:37716 name: mixed diacylamine @@ -14296,6 +23817,44 @@ subset: 3_STAR synonym: "mixed diacylamines" RELATED [ChEBI] is_a: CHEBI:24782 ! imide +[Term] +id: CHEBI:37733 +name: EC 3.1.1.8 (cholinesterase) inhibitor +namespace: chebi_ontology +def: "An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8)." [] +subset: 3_STAR +synonym: "anticholineesterase inhibitor" RELATED [ChEBI] +synonym: "anticholineesterase inhibitors" RELATED [ChEBI] +synonym: "anticholinesterase" RELATED [ChEBI] +synonym: "anticholinesterases" RELATED [ChEBI] +synonym: "BChE inhibitor" RELATED [ChEBI] +synonym: "BChE inhibitors" RELATED [ChEBI] +synonym: "benzoylcholinesterase inhibitor" RELATED [ChEBI] +synonym: "benzoylcholinesterase inhibitors" RELATED [ChEBI] +synonym: "BtChoEase inhibitor" RELATED [ChEBI] +synonym: "BtChoEase inhibitors" RELATED [ChEBI] +synonym: "butyrylcholine esterase inhibitor" RELATED [ChEBI] +synonym: "butyrylcholine esterase inhibitors" RELATED [ChEBI] +synonym: "butyrylcholinesterase inhibitor" RELATED [ChEBI] +synonym: "butyrylcholinesterase inhibitors" RELATED [ChEBI] +synonym: "choline esterase II (unspecific) inhibitor" RELATED [ChEBI] +synonym: "choline esterase II (unspecific) inhibitors" RELATED [ChEBI] +synonym: "choline esterase inhibitor" RELATED [ChEBI] +synonym: "choline esterase inhibitors" RELATED [ChEBI] +synonym: "cholinesterase (EC 3.1.1.8) inhibitor" RELATED [ChEBI] +synonym: "cholinesterase (EC 3.1.1.8) inhibitors" RELATED [ChEBI] +synonym: "cholinesterase inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.1.8 (cholinesterase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.1.8 inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.1.8 inhibitors" RELATED [ChEBI] +synonym: "non-specific cholinesterase inhibitor" RELATED [ChEBI] +synonym: "non-specific cholinesterase inhibitors" RELATED [ChEBI] +synonym: "propionylcholinesterase inhibitor" RELATED [ChEBI] +synonym: "propionylcholinesterase inhibitors" RELATED [ChEBI] +synonym: "pseudocholinesterase inhibitor" RELATED [ChEBI] +synonym: "pseudocholinesterase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76773 ! EC 3.1.1.* (carboxylic ester hydrolase) inhibitor + [Term] id: CHEBI:37734 name: phosphoric ester @@ -14305,6 +23864,18 @@ subset: 1_STAR is_a: CHEBI:26079 ! phosphoric acid derivative is_a: CHEBI:35701 ! ester +[Term] +id: CHEBI:37793 +name: amino sulfonic acid +namespace: chebi_ontology +def: "An organosulfonic acid containing one or more amino groups." [] +subset: 3_STAR +synonym: "amino sulfonic acids" RELATED [ChEBI] +synonym: "aminosulfonic acid" RELATED [ChEBI] +synonym: "aminosulfonic acids" RELATED [ChEBI] +is_a: CHEBI:33551 ! organosulfonic acid +is_a: CHEBI:50047 ! organic amino compound + [Term] id: CHEBI:37826 name: sulfuric acid derivative @@ -14341,6 +23912,24 @@ xref: CAS:9002-72-6 {source="KEGG COMPOUND"} xref: KEGG:C18181 is_a: CHEBI:24621 ! hormone +[Term] +id: CHEBI:37848 +name: plant hormone +namespace: chebi_ontology +alt_id: CHEBI:26158 +def: "A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds." [] +subset: 3_STAR +synonym: "phytohormone" RELATED [ChEBI] +synonym: "phytohormones" RELATED [ChEBI] +synonym: "plant growth factor" RELATED [ChEBI] +synonym: "plant growth factors" RELATED [ChEBI] +synonym: "plant growth hormone" RELATED [ChEBI] +synonym: "plant growth hormones" RELATED [ChEBI] +synonym: "plant hormones" RELATED [ChEBI] +xref: Wikipedia:Phytohormone +is_a: CHEBI:24621 ! hormone +is_a: CHEBI:26155 ! plant growth regulator + [Term] id: CHEBI:37886 name: adrenergic agonist @@ -14354,6 +23943,34 @@ synonym: "adrenomimetic" RELATED [ChEBI] synonym: "adrenomimetics" RELATED [ChEBI] is_a: CHEBI:37962 ! adrenergic agent +[Term] +id: CHEBI:37887 +name: adrenergic antagonist +namespace: chebi_ontology +def: "An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists." [] +subset: 3_STAR +synonym: "adrenergic antagonists" RELATED [ChEBI] +synonym: "adrenergic blockaders" RELATED [ChEBI] +synonym: "adrenergic blocker" RELATED [ChEBI] +synonym: "adrenergic blockers" RELATED [ChEBI] +synonym: "adrenergic receptor blockaders" RELATED [ChEBI] +synonym: "adrenoceptor antagonists" RELATED [IUPHAR] +is_a: CHEBI:37962 ! adrenergic agent + +[Term] +id: CHEBI:37890 +name: alpha-adrenergic antagonist +namespace: chebi_ontology +def: "An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma." [] +subset: 3_STAR +synonym: "alpha-adrenergic antagonists" RELATED [ChEBI] +synonym: "alpha-adrenergic blocker" RELATED [ChEBI] +synonym: "alpha-adrenergic blockers" RELATED [ChEBI] +synonym: "alpha-adrenergic receptor blockaders" RELATED [ChEBI] +synonym: "alpha-adrenoceptor antagonists" RELATED [IUPHAR] +is_a: CHEBI:37887 ! adrenergic antagonist +is_a: CHEBI:48539 ! alpha-adrenergic drug + [Term] id: CHEBI:37894 name: 5alpha-androst-16-en-3-one @@ -14389,6 +24006,17 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "272.42502" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "272.21402" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)C=CC[C@@]34[H])[C@@]1(C)CCC(=O)C2" xsd:string +[Term] +id: CHEBI:37912 +name: hydroxycoumarin +namespace: chebi_ontology +alt_id: CHEBI:24691 +alt_id: CHEBI:24692 +def: "Any coumarin carrying at least one hydroxy substituent." [] +subset: 3_STAR +synonym: "hydroxycoumarins" RELATED [ChEBI] +is_a: CHEBI:23403 ! coumarins + [Term] id: CHEBI:37925 name: androst-16-ene @@ -14425,6 +24053,171 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "258.44150" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "258.23475" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)C=CC[C@@]3([H])[C@]1([H])CC2" xsd:string +[Term] +id: CHEBI:37930 +name: phenothiazine antipsychotic drug +namespace: chebi_ontology +subset: 3_STAR +synonym: "phenothiazine antipsychotic drugs" RELATED [ChEBI] +synonym: "phenothiazine antipsychotics" RELATED [ChEBI] +synonym: "phenothiazine neuroleptics" RELATED [ChEBI] +is_a: CHEBI:65190 ! first generation antipsychotic + +[Term] +id: CHEBI:37931 +name: 10H-phenothiazine +namespace: chebi_ontology +def: "The 10H-tautomer of phenothiazine." [] +subset: 3_STAR +synonym: "10H-Phenothiazin" RELATED [NIST_Chemistry_WebBook] +synonym: "10H-phenothiazine" EXACT IUPAC_NAME [IUPAC] +synonym: "dibenzo-1,4-thiazine" RELATED [ChemIDplus] +synonym: "phenothiazine" RELATED [NIST_Chemistry_WebBook] +xref: Beilstein:143237 {source="Beilstein"} +xref: CAS:92-84-2 {source="ChemIDplus"} +xref: CAS:92-84-2 {source="NIST Chemistry WebBook"} +xref: LINCS:LSM-3324 +xref: PMID:25382702 {source="Europe PMC"} +xref: PMID:26661932 {source="Europe PMC"} +xref: Reaxys:143237 {source="Reaxys"} +xref: Wikipedia:Phenothiazine +is_a: CHEBI:37932 ! phenothiazine +relationship: has_role CHEBI:173084 ! ferroptosis inhibitor +relationship: has_role CHEBI:48578 ! radical scavenger +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_tautomer_of CHEBI:37933 ! 4aH-phenothiazine +relationship: is_tautomer_of CHEBI:37934 ! 1H-phenothiazine +relationship: is_tautomer_of CHEBI:37935 ! 3H-phenothiazine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9NS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WJFKNYWRSNBZNX-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "199.27260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.04557" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1c2ccccc2Sc2ccccc12" xsd:string + +[Term] +id: CHEBI:37932 +name: phenothiazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "Phenothiazin" RELATED [ChEBI] +synonym: "phenothiazine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:36416 ! mancude organic heterotricyclic parent +is_a: CHEBI:38093 ! phenothiazines +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9NS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "199.273" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.04557" xsd:string + +[Term] +id: CHEBI:37933 +name: 4aH-phenothiazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "4aH-phenothiazine" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1211644 {source="Beilstein"} +is_a: CHEBI:37932 ! phenothiazine +relationship: is_tautomer_of CHEBI:37931 ! 10H-phenothiazine +relationship: is_tautomer_of CHEBI:37934 ! 1H-phenothiazine +relationship: is_tautomer_of CHEBI:37935 ! 3H-phenothiazine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9NS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,11H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UTOHXUCINHSOMQ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "199.27260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.04557" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "S1C2C=CC=CC2=Nc2ccccc12" xsd:string + +[Term] +id: CHEBI:37934 +name: 1H-phenothiazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "1H-phenothiazine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:37932 ! phenothiazine +relationship: is_tautomer_of CHEBI:37931 ! 10H-phenothiazine +relationship: is_tautomer_of CHEBI:37933 ! 4aH-phenothiazine +relationship: is_tautomer_of CHEBI:37935 ! 3H-phenothiazine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9NS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-5,7-8H,6H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QWXDTDWOYQPERX-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "199.27260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.04557" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1C=CC=C2Sc3ccccc3N=C12" xsd:string + +[Term] +id: CHEBI:37935 +name: 3H-phenothiazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "3H-phenothiazine" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:37932 ! phenothiazine +relationship: is_tautomer_of CHEBI:37931 ! 10H-phenothiazine +relationship: is_tautomer_of CHEBI:37933 ! 4aH-phenothiazine +relationship: is_tautomer_of CHEBI:37934 ! 1H-phenothiazine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H9NS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-3,5-8H,4H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FIICCGOYRVMEPV-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "199.27260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "199.04557" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1C=CC2=Nc3ccccc3SC2=C1" xsd:string + +[Term] +id: CHEBI:37941 +name: clopidogrel +namespace: chebi_ontology +def: "A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks." [] +subset: 3_STAR +synonym: "(+)-Clopidogrel" RELATED [ChEBI] +synonym: "clopidogrel" RELATED INN [WHO_MedNet] +synonym: "clopidogrelum" RELATED INN [ChemIDplus] +synonym: "methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:8151914 {source="Beilstein"} +xref: CAS:113665-84-2 {source="ChemIDplus"} +xref: Drug_Central:708 {source="DrugCentral"} +xref: DrugBank:DB00758 +xref: LINCS:LSM-5415 +xref: Patent:EP281459 +xref: Patent:EP99802 +xref: Patent:US4529596 +xref: Patent:US4847265 +xref: PMID:10983738 {source="Europe PMC"} +xref: PMID:11095576 {source="Europe PMC"} +xref: PMID:11701941 {source="Europe PMC"} +xref: PMID:16802846 {source="Europe PMC"} +xref: PMID:18520712 {source="Europe PMC"} +xref: PMID:18708826 {source="Europe PMC"} +xref: PMID:19573725 {source="Europe PMC"} +xref: Wikipedia:Clopidogrel +is_a: CHEBI:25248 ! methyl ester +is_a: CHEBI:37942 ! thienopyridine +is_a: CHEBI:83403 ! monochlorobenzenes +relationship: has_functional_parent CHEBI:9588 ! ticlopidine +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50427 ! platelet aggregation inhibitor +relationship: has_role CHEBI:68563 ! P2Y12 receptor antagonist +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H16ClNO2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GKTWGGQPFAXNFI-HNNXBMFYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "321.82200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "321.05903" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)[C@@H](N1CCc2sccc2C1)c1ccccc1Cl" xsd:string + +[Term] +id: CHEBI:37942 +name: thienopyridine +namespace: chebi_ontology +def: "Any organic heterobicyclic compound whose skeleton results from the formal ortho-fusion of any bond of a pyridine with any bond of a thiophene." [] +subset: 3_STAR +synonym: "thienopyridines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38106 ! organosulfur heterocyclic compound + [Term] id: CHEBI:37947 name: benzothiazoles @@ -14434,6 +24227,53 @@ is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound +[Term] +id: CHEBI:37955 +name: H1-receptor antagonist +namespace: chebi_ontology +def: "H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine." [] +subset: 3_STAR +synonym: "classical antihistamines" RELATED [ChEBI] +synonym: "classical antihistaminics" RELATED [ChEBI] +synonym: "H1 antihistaminics" RELATED [ChEBI] +synonym: "H1 receptor antagonists" RELATED [IUPHAR] +synonym: "H1 receptor blockaders" RELATED [ChEBI] +synonym: "H1-receptor antagonists" RELATED [ChEBI] +synonym: "H1-receptor blocker" RELATED [ChEBI] +synonym: "H1-receptor blockers" RELATED [ChEBI] +xref: PMID:22035879 {source="Europe PMC"} +is_a: CHEBI:37956 ! histamine antagonist + +[Term] +id: CHEBI:37956 +name: histamine antagonist +namespace: chebi_ontology +def: "Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists." [] +subset: 3_STAR +synonym: "antihistamine" RELATED [ChEBI] +synonym: "antihistamines" RELATED [ChEBI] +synonym: "antihistaminico" RELATED [ChEBI] +synonym: "antihistaminics" RELATED [ChEBI] +synonym: "histamine receptor blocker" RELATED [ChEBI] +synonym: "histamine receptor blockers" RELATED [ChEBI] +xref: PMID:22035879 {source="Europe PMC"} +xref: Wikipedia:Antihistamines +is_a: CHEBI:37957 ! histaminergic drug +is_a: CHEBI:48706 ! antagonist + +[Term] +id: CHEBI:37957 +name: histaminergic drug +namespace: chebi_ontology +def: "Drugs used for their actions on histaminergic systems." [] +subset: 3_STAR +synonym: "histamine agents" RELATED [ChEBI] +synonym: "histamine drugs" RELATED [ChEBI] +synonym: "histaminergic agent" RELATED [ChEBI] +synonym: "histaminergic agents" RELATED [ChEBI] +synonym: "histaminergic drugs" RELATED [ChEBI] +is_a: CHEBI:35942 ! neurotransmitter agent + [Term] id: CHEBI:37962 name: adrenergic agent @@ -14447,6 +24287,47 @@ synonym: "adrenergic neuron agents" RELATED [ChEBI] synonym: "adrenergics" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent +[Term] +id: CHEBI:37963 +name: pyranone +namespace: chebi_ontology +def: "Any of a class of cyclic chemical compounds that contain an unsaturated six-membered ring with one ring oxygen atom and an oxo substituent." [] +subset: 3_STAR +synonym: "oxopyrans" RELATED [ChEBI] +synonym: "pyranone" EXACT [ChEBI] +synonym: "pyranones" RELATED [ChEBI] +synonym: "pyrone" RELATED [ChEBI] +synonym: "pyrones" RELATED [ChEBI] +is_a: CHEBI:26407 ! pyrans + +[Term] +id: CHEBI:38001 +name: 2,6-diaminopurines +namespace: chebi_ontology +def: "Any aminopurine that has amino substituents at positions 2 and 6, and their substituted derivatives." [] +subset: 3_STAR +synonym: "2,6-diaminopurines" EXACT [ChEBI] +is_a: CHEBI:22527 ! aminopurine + +[Term] +id: CHEBI:38068 +name: antimalarial +namespace: chebi_ontology +def: "A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human." [] +subset: 3_STAR +synonym: "antimalarials" RELATED [ChEBI] +is_a: CHEBI:64915 ! antiplasmodial drug + +[Term] +id: CHEBI:38070 +name: anti-arrhythmia drug +namespace: chebi_ontology +def: "A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres." [] +subset: 3_STAR +synonym: "anti-arrhythmia agent" RELATED [ChEBI] +synonym: "antiarrhythmic agent" RELATED [ChEBI] +is_a: CHEBI:35554 ! cardiovascular drug + [Term] id: CHEBI:38077 name: polypyrrole @@ -14459,6 +24340,13 @@ synonym: "PPys" RELATED [ChEBI] xref: Beilstein:8538310 {source="Beilstein"} is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +[Term] +id: CHEBI:38093 +name: phenothiazines +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:26979 ! organic heterotricyclic compound + [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound @@ -14470,6 +24358,15 @@ synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound +[Term] +id: CHEBI:38102 +name: triazines +namespace: chebi_ontology +def: "Compounds based on a triazine skeleton." [] +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:50893 ! azaarene + [Term] id: CHEBI:38104 name: oxacycle @@ -14502,6 +24399,40 @@ subset: 3_STAR synonym: "cardiotonic drugs" RELATED [ChEBI] is_a: CHEBI:35554 ! cardiovascular drug +[Term] +id: CHEBI:38161 +name: chelator +namespace: chebi_ontology +alt_id: CHEBI:23090 +alt_id: CHEBI:3585 +alt_id: CHEBI:6789 +def: "A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate." [] +subset: 3_STAR +synonym: "Chelating agent" RELATED [KEGG_COMPOUND] +synonym: "chelating agents" RELATED [ChEBI] +synonym: "chelators" RELATED [ChEBI] +synonym: "complexon" RELATED [ChEBI] +synonym: "Metal chelator" RELATED [KEGG_COMPOUND] +xref: KEGG:C00917 +xref: KEGG:C02169 +is_a: CHEBI:52214 ! ligand + +[Term] +id: CHEBI:38163 +name: organic heterotetracyclic compound +namespace: chebi_ontology +subset: 3_STAR +synonym: "organic heterotetracyclic compounds" RELATED [ChEBI] +is_a: CHEBI:38166 ! organic heteropolycyclic compound + +[Term] +id: CHEBI:38164 +name: organic heteropentacyclic compound +namespace: chebi_ontology +subset: 3_STAR +synonym: "organic heteropentacyclic compounds" RELATED [ChEBI] +is_a: CHEBI:38166 ! organic heteropolycyclic compound + [Term] id: CHEBI:38166 name: organic heteropolycyclic compound @@ -14529,6 +24460,32 @@ subset: 3_STAR synonym: "polycyclic heteroarenes" RELATED [ChEBI] is_a: CHEBI:33833 ! heteroarene +[Term] +id: CHEBI:38215 +name: calcium channel blocker +namespace: chebi_ontology +def: "One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools." [] +subset: 3_STAR +synonym: "calcium channel antagonist" RELATED [ChEBI] +synonym: "calcium channel antagonists" RELATED [ChEBI] +synonym: "calcium channel blockers" RELATED [ChEBI] +is_a: CHEBI:38808 ! calcium channel modulator + +[Term] +id: CHEBI:38222 +name: hydrocarbyl anion +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:25696 ! organic anion + +[Term] +id: CHEBI:38234 +name: DNA polymerase inhibitor +namespace: chebi_ontology +def: "Any inhibitor of a DNA polymerase." [] +subset: 3_STAR +is_a: CHEBI:76815 ! EC 2.7.7.* (nucleotidyltransferase) inhibitor + [Term] id: CHEBI:38260 name: pyrrolidines @@ -14547,6 +24504,43 @@ namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:38304 ! diazolidine +[Term] +id: CHEBI:38267 +name: boronic acid +namespace: chebi_ontology +def: "The simplest boronic acid, consisting of borane with two of the hydrogens substituted by hydroxy groups." [] +subset: 3_STAR +synonym: "BH(OH)2" RELATED [IUPAC] +synonym: "boronic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "dihydroxyborane" EXACT IUPAC_NAME [IUPAC] +synonym: "hydridodihydroxidoboron" EXACT IUPAC_NAME [IUPAC] +xref: CAS:13780-71-7 {source="ChemIDplus"} +xref: Gmelin:141308 {source="Gmelin"} +xref: Reaxys:11573126 {source="Reaxys"} +is_a: CHEBI:38269 ! boronic acids +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "BH3O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/BH3O2/c2-1-3/h1-3H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZADPBFCGQRWHPN-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "45.83362" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "46.02261" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OB([H])O[H]" xsd:string + +[Term] +id: CHEBI:38269 +name: boronic acids +namespace: chebi_ontology +def: "Compounds having the structure RB(OH)2." [] +subset: 3_STAR +synonym: "boronic acids" EXACT IUPAC_NAME [IUPAC] +xref: Wikipedia:Boronic_acid +is_a: CHEBI:33145 ! boron oxoacid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "BH2O2R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "44.82600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.01478" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OB(O)[*]" xsd:string + [Term] id: CHEBI:38290 name: L-ascorbate @@ -14613,6 +24607,21 @@ subset: 3_STAR is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +[Term] +id: CHEBI:38314 +name: pyrazines +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:38313 ! diazines + +[Term] +id: CHEBI:38315 +name: beta-D-arabinoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "beta-D-arabinosides" RELATED [ChEBI] +is_a: CHEBI:22601 ! arabinoside + [Term] id: CHEBI:38323 name: cholinergic drug @@ -14650,6 +24659,15 @@ synonym: "muscarinic cholinergic agonist" RELATED [ChEBI] synonym: "muscarinic cholinergic agonists" RELATED [ChEBI] is_a: CHEBI:38324 ! cholinergic agonist +[Term] +id: CHEBI:38337 +name: pyrimidone +namespace: chebi_ontology +def: "A pyrimidine carrying one or more oxo substituents." [] +subset: 3_STAR +synonym: "pyrimidones" RELATED [ChEBI] +is_a: CHEBI:39447 ! pyrimidines + [Term] id: CHEBI:38338 name: aminopyrimidine @@ -14660,6 +24678,29 @@ synonym: "aminopyrimidines" RELATED [ChEBI] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:39447 ! pyrimidines +[Term] +id: CHEBI:38355 +name: hex-4-enoic acid +namespace: chebi_ontology +def: "A hexenoic acid with the double bond at position 4." [] +subset: 3_STAR +synonym: "4-hexenoic acid" RELATED [LIPID_MAPS] +synonym: "4-hexenoic acids" RELATED [ChEBI] +synonym: "gamma-hexenoic acid" RELATED [LIPID_MAPS] +synonym: "gamma-hexenoic acids" RELATED [ChEBI] +synonym: "hex-4-enoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "hex-4-enoic acids" RELATED [ChEBI] +xref: Beilstein:1720995 {source="Beilstein"} +xref: LIPID_MAPS_instance:LMFA01030010 {source="LIPID MAPS"} +is_a: CHEBI:24580 ! hexenoic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H10O2/c1-2-3-4-5-6(7)8/h2-3H,4-5H2,1H3,(H,7,8)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NIDHFQDUBOVBKZ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "114.14240" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "114.06808" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(C)=CCCC(O)=O" xsd:string + [Term] id: CHEBI:38418 name: 1,3-thiazoles @@ -14678,6 +24719,14 @@ subset: 3_STAR synonym: "1-benzopyrans" RELATED [ChEBI] is_a: CHEBI:22727 ! benzopyran +[Term] +id: CHEBI:38445 +name: chromenone +namespace: chebi_ontology +subset: 3_STAR +synonym: "chromenones" RELATED [ChEBI] +is_a: CHEBI:23232 ! chromenes + [Term] id: CHEBI:38460 name: methylindole @@ -14688,6 +24737,127 @@ synonym: "methylindole" EXACT [ChEBI] synonym: "methylindoles" RELATED [ChEBI] is_a: CHEBI:24828 ! indoles +[Term] +id: CHEBI:38481 +name: alkaloid ester +namespace: chebi_ontology +subset: 3_STAR +synonym: "alkaloid esters" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid +is_a: CHEBI:33308 ! carboxylic ester + +[Term] +id: CHEBI:38482 +name: indole alkaloid fundamental parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "indole alkaloid fundamental parents" RELATED [ChEBI] +is_a: CHEBI:35506 ! alkaloid fundamental parent + +[Term] +id: CHEBI:38496 +name: electron-transport chain inhibitor +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:76932 ! pathway inhibitor + +[Term] +id: CHEBI:38497 +name: respiratory-chain inhibitor +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:38496 ! electron-transport chain inhibitor + +[Term] +id: CHEBI:38500 +name: EC 1.9.3.1 (cytochrome c oxidase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:38501 +alt_id: CHEBI:62966 +def: "An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1)." [] +subset: 3_STAR +synonym: "CcO inhibitor" RELATED [ChEBI] +synonym: "complex IV (mitochondrial electron transport) inhibitor" RELATED [ChEBI] +synonym: "complex IV (mitochondrial electron transport) inhibitors" RELATED [ChEBI] +synonym: "cytochrome a3 inhibitor" RELATED [ChEBI] +synonym: "cytochrome a3 inhibitors" RELATED [ChEBI] +synonym: "cytochrome aa3 inhibitor" RELATED [ChEBI] +synonym: "cytochrome aa3 inhibitors" RELATED [ChEBI] +synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitor" RELATED [ChEBI] +synonym: "cytochrome c oxidase (EC 1.9.3.1) inhibitors" RELATED [ChEBI] +synonym: "cytochrome c oxidase inhibitor" RELATED [ChEBI] +synonym: "cytochrome c oxidase inhibitors" RELATED [ChEBI] +synonym: "cytochrome oxidase inhibitor" RELATED [ChEBI] +synonym: "cytochrome oxidase inhibitors" RELATED [ChEBI] +synonym: "cytochrome-c oxidase inhibitor" RELATED [ChEBI] +synonym: "cytochrome-c oxidase inhibitors" RELATED [ChEBI] +synonym: "EC 1.9.3.1 (cytochrome c oxidase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.9.3.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.9.3.1 inhibitors" RELATED [ChEBI] +synonym: "ferrocytochrome c oxidase inhibitor" RELATED [ChEBI] +synonym: "ferrocytochrome c oxidase inhibitors" RELATED [ChEBI] +synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "ferrocytochrome-c:oxygen oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "indophenol oxidase inhibitor" RELATED [ChEBI] +synonym: "indophenol oxidase inhibitors" RELATED [ChEBI] +synonym: "indophenolase inhibitor" RELATED [ChEBI] +synonym: "indophenolase inhibitors" RELATED [ChEBI] +synonym: "mitochondrial complex IV inhibitor" RELATED [ChEBI] +synonym: "mitochondrial complex IV inhibitors" RELATED [ChEBI] +synonym: "mitochondrial cytochrome-c oxidase inhibitors" RELATED [ChEBI] +synonym: "NADH cytochrome c oxidase inhibitor" RELATED [ChEBI] +synonym: "NADH cytochrome c oxidase inhibitors" RELATED [ChEBI] +synonym: "Warburg's respiratory enzyme inhibitor" RELATED [ChEBI] +synonym: "Warburg's respiratory enzyme inhibitors" RELATED [ChEBI] +xref: PMID:12969439 {source="Europe PMC"} +xref: Wikipedia:Cytochrome_c_oxidase +is_a: CHEBI:25355 ! mitochondrial respiratory-chain inhibitor +is_a: CHEBI:76870 ! EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor + +[Term] +id: CHEBI:38515 +name: isoquinoline alkaloid fundamental parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "isoquinoline alkaloid fundamental parents" RELATED [ChEBI] +is_a: CHEBI:35506 ! alkaloid fundamental parent + +[Term] +id: CHEBI:38523 +name: benzazepine alkaloid +namespace: chebi_ontology +subset: 3_STAR +synonym: "benzazepine alkaloids" RELATED [ChEBI] +is_a: CHEBI:22315 ! alkaloid +is_a: CHEBI:35676 ! benzazepine + +[Term] +id: CHEBI:38527 +name: benzazepine alkaloid fundamental parent +namespace: chebi_ontology +subset: 3_STAR +synonym: "benzazepine alkaloid fundamental parents" RELATED [ChEBI] +is_a: CHEBI:35506 ! alkaloid fundamental parent + +[Term] +id: CHEBI:38530 +name: quinazolines +namespace: chebi_ontology +def: "Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives." [] +subset: 3_STAR +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:38532 +name: hydrazone +namespace: chebi_ontology +def: "Compounds having the structure R2C=NNR2, formally derived from aldehydes or ketones by replacing =O by =NNH2 (or substituted analogues)." [] +subset: 3_STAR +synonym: "hydrazones" EXACT IUPAC_NAME [IUPAC] +synonym: "hydrazones" RELATED [ChEBI] +is_a: CHEBI:35352 ! organonitrogen compound + [Term] id: CHEBI:38560 name: simple protein @@ -14697,6 +24867,17 @@ synonym: "simple proteins" RELATED [ChEBI] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein +[Term] +id: CHEBI:38582 +name: difluorobenzene +namespace: chebi_ontology +def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluorine atoms." [] +subset: 3_STAR +synonym: "Difluorbenzol" RELATED [ChEBI] +synonym: "difluorobenzene" EXACT IUPAC_NAME [IUPAC] +synonym: "difluorobenzenes" RELATED [ChEBI] +is_a: CHEBI:35496 ! fluorobenzenes + [Term] id: CHEBI:38631 name: aminoalkylindole @@ -14726,6 +24907,74 @@ synonym: "Na channel blocker" RELATED [ChEBI] synonym: "sodium channel blockers" RELATED [ChEBI] is_a: CHEBI:39000 ! sodium channel modulator +[Term] +id: CHEBI:38637 +name: tyrosine kinase inhibitor +namespace: chebi_ontology +def: "Any protein kinase inhibitor that interferes with the action of tyrosine kinase." [] +subset: 3_STAR +synonym: "protein tyrosine kinase inhibitor" RELATED [ChEBI] +synonym: "protein tyrosine kinase inhibitors" RELATED [ChEBI] +synonym: "TKI inhibitor" RELATED [ChEBI] +synonym: "TKI inhibitors" RELATED [ChEBI] +synonym: "tyrosine kinase inhibitors" RELATED [ChEBI] +synonym: "tyrphostin" RELATED [ChEBI] +synonym: "tyrphostins" RELATED [ChEBI] +xref: Wikipedia:Tyrosine-kinase_inhibitor +is_a: CHEBI:37699 ! protein kinase inhibitor + +[Term] +id: CHEBI:38653 +name: methylbutyric acid +namespace: chebi_ontology +def: "A methyl-branched fatty acid comprising a butyric acid core carrying a single methyl substituent." [] +subset: 3_STAR +synonym: "methylbutanoic acid" EXACT IUPAC_NAME [IUPAC] +xref: PMID:13105653 {source="Europe PMC"} +is_a: CHEBI:26666 ! short-chain fatty acid +is_a: CHEBI:39417 ! branched-chain saturated fatty acid +is_a: CHEBI:62499 ! methyl-branched fatty acid +relationship: has_functional_parent CHEBI:30772 ! butyric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "102.132" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string + +[Term] +id: CHEBI:38655 +name: (S)-2-methylbutyric acid +namespace: chebi_ontology +def: "The (S)-enantiomer of 2-methylbutanoic acid." [] +subset: 3_STAR +synonym: "(2S)-2-methylbutanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-2-methylbutanoic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "(S)-alpha-methylbutanoic acid" RELATED [ChEBI] +xref: Beilstein:1720485 {source="Beilstein"} +xref: Beilstein:3648078 {source="Beilstein"} +xref: CAS:1730-91-2 {source="NIST Chemistry WebBook"} +xref: CAS:1730-91-2 {source="ChemIDplus"} +xref: Gmelin:532948 {source="Gmelin"} +xref: PMID:2026560 {source="Europe PMC"} +is_a: CHEBI:37070 ! 2-methylbutyric acid +relationship: is_conjugate_acid_of CHEBI:145932 ! (S)-2-methylbutanoate +relationship: is_enantiomer_of CHEBI:45525 ! (R)-2-methylbutyric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/t4-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLAMNBDJUVNPJU-BYPYZUCNSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "102.13170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@H](C)C(O)=O" xsd:string + +[Term] +id: CHEBI:38670 +name: pyrrolopyrimidine +namespace: chebi_ontology +subset: 3_STAR +synonym: "pyrrolopyrimidines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + [Term] id: CHEBI:38700 name: organic sodium salt @@ -14736,6 +24985,13 @@ synonym: "organic sodium salts" RELATED [ChEBI] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt +[Term] +id: CHEBI:38702 +name: inorganic sodium salt +synonym: "inorganic sodium salts" RELATED [] +is_a: CHEBI:24839 ! inorganic salt +is_a: CHEBI:26714 ! sodium salt + [Term] id: CHEBI:38716 name: carboxylic acid dianion @@ -14746,6 +25002,39 @@ synonym: "carboxylic acid dianion" EXACT [ChEBI] synonym: "carboxylic acid dianions" RELATED [ChEBI] is_a: CHEBI:29067 ! carboxylic acid anion +[Term] +id: CHEBI:38767 +name: benzothiophenes +namespace: chebi_ontology +alt_id: CHEBI:38766 +subset: 3_STAR +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38106 ! organosulfur heterocyclic compound + +[Term] +id: CHEBI:38769 +name: indazoles +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:38777 +name: azetidines +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:38785 +name: morpholines +namespace: chebi_ontology +def: "Any compound containing morpholine as part of its structure." [] +subset: 3_STAR +is_a: CHEBI:46952 ! oxazinane + [Term] id: CHEBI:38793 name: pteroate @@ -14791,6 +25080,70 @@ namespace: chebi_ontology subset: 3_STAR is_a: CHEBI:22494 ! aminobenzoate +[Term] +id: CHEBI:38808 +name: calcium channel modulator +namespace: chebi_ontology +def: "A membrane transport modulator that is able to regulate intracellular calcium levels." [] +subset: 3_STAR +synonym: "calcium channel modulators" RELATED [ChEBI] +is_a: CHEBI:38632 ! membrane transport modulator + +[Term] +id: CHEBI:38824 +name: fluorocarbon +namespace: chebi_ontology +def: "Compounds consisting wholly of fluorine and carbon." [] +subset: 3_STAR +synonym: "fluorocarbon" EXACT [ChEBI] +synonym: "fluorocarbons" EXACT IUPAC_NAME [IUPAC] +synonym: "fluorocarbons" RELATED [ChEBI] +is_a: CHEBI:37143 ! organofluorine compound + +[Term] +id: CHEBI:38825 +name: tetrafluoromethane +namespace: chebi_ontology +subset: 3_STAR +synonym: "carbon tetrafluoride" RELATED [ChemIDplus] +synonym: "CF4" RELATED [IUPAC] +synonym: "Freon 14" RELATED [NIST_Chemistry_WebBook] +synonym: "Halon 14" RELATED [NIST_Chemistry_WebBook] +synonym: "perfluoromethane" RELATED [NIST_Chemistry_WebBook] +synonym: "tetrafluoridocarbon" RELATED [IUPAC] +synonym: "Tetrafluorkohlenstoff" RELATED [ChEBI] +synonym: "Tetrafluormethan" RELATED [ChEBI] +synonym: "tetrafluorocarbon" RELATED [ChemIDplus] +synonym: "tetrafluoromethane" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:1697288 {source="Beilstein"} +xref: CAS:75-73-0 {source="NIST Chemistry WebBook"} +xref: CAS:75-73-0 {source="ChemIDplus"} +xref: Gmelin:2016 {source="Gmelin"} +is_a: CHEBI:38824 ! fluorocarbon +is_a: CHEBI:39281 ! fluoromethanes +relationship: has_role CHEBI:78433 ! refrigerant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CF4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CF4/c2-1(3,4)5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "TXEYQDLBPFQVAA-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "88.00431" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.99361" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "FC(F)(F)F" xsd:string + +[Term] +id: CHEBI:38831 +name: 2-benzofurans +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:35259 ! benzofurans + +[Term] +id: CHEBI:38836 +name: 1-benzothiophenes +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:38767 ! benzothiophenes + [Term] id: CHEBI:38856 name: halophenol @@ -14851,6 +25204,16 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "4541.06600" xsd:strin property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "4538.25937" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O" xsd:string +[Term] +id: CHEBI:38932 +name: pyridopyrimidine +namespace: chebi_ontology +def: "Any organic heterobicyclic compound consisting of a pyridine ring ortho-fused at any position to a pyrimidine ring." [] +subset: 3_STAR +synonym: "pyridopyrimidine" EXACT [ChEBI] +synonym: "pyridopyrimidines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound + [Term] id: CHEBI:38958 name: indole alkaloid @@ -14994,6 +25357,107 @@ synonym: "Lewis-Base" RELATED [ChEBI] is_a: CHEBI:17891 ! donor is_a: CHEBI:22695 ! base +[Term] +id: CHEBI:39162 +name: (R)-nicotine +namespace: chebi_ontology +def: "A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has R-configuration." [] +subset: 3_STAR +synonym: "(+)-nicotine" RELATED [ChemIDplus] +synonym: "(R)-3-(1-methyl-2-pyrrolidinyl)pyridine" RELATED [ChemIDplus] +synonym: "3-[(2R)-1-methylpyrrolidin-2-yl]pyridine" EXACT IUPAC_NAME [IUPAC] +synonym: "d-nicotine" RELATED [ChemIDplus] +synonym: "pseudonicotine" RELATED [ChemIDplus] +xref: Beilstein:4666243 "ChemIDplus" +xref: Beilstein:4666243 {source="ChemIDplus"} +xref: Beilstein:82110 "Beilstein" +xref: Beilstein:82110 {source="Beilstein"} +xref: CAS:25162-00-9 "ChemIDplus" +xref: CAS:25162-00-9 {source="ChemIDplus"} +xref: KEGG:C16386 +is_a: CHEBI:138000 ! 3-(1-methylpyrrolidin-2-yl)pyridine +relationship: is_conjugate_base_of CHEBI:79008 ! (R)-nicotinium(1+) +relationship: is_enantiomer_of CHEBI:17688 ! (S)-nicotine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNICXCGAKADSCV-SNVBAGLBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "162.23160" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "162.11570" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN1CCC[C@@H]1c1cccnc1" xsd:string + +[Term] +id: CHEBI:39268 +name: dibenzothiazepine +namespace: chebi_ontology +subset: 3_STAR +synonym: "dibenzothiazepines" RELATED [ChEBI] +is_a: CHEBI:26979 ! organic heterotricyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38106 ! organosulfur heterocyclic compound + +[Term] +id: CHEBI:39270 +name: naphthofuran +namespace: chebi_ontology +subset: 3_STAR +synonym: "naphthofurans" RELATED [ChEBI] +is_a: CHEBI:26979 ! organic heterotricyclic compound +is_a: CHEBI:38104 ! oxacycle + +[Term] +id: CHEBI:39279 +name: halomethane +namespace: chebi_ontology +def: "A haloalkane that is methane in which one (or more) of the hydrogens have been replaced by a halogen atom/halogen atoms." [] +subset: 3_STAR +synonym: "halomethane" EXACT [ChEBI] +synonym: "halomethanes" RELATED [ChEBI] +is_a: CHEBI:24469 ! haloalkane +is_a: CHEBI:64708 ! one-carbon compound +relationship: has_parent_hydride CHEBI:16183 ! methane + +[Term] +id: CHEBI:39281 +name: fluoromethanes +namespace: chebi_ontology +def: "A halomethane that is methane in which one or more hydrogens has been replaced by fluorine." [] +subset: 3_STAR +is_a: CHEBI:24067 ! fluoroalkane +is_a: CHEBI:39279 ! halomethane + +[Term] +id: CHEBI:39317 +name: growth regulator +namespace: chebi_ontology +def: "Any chemical substance that inhibits the life-cycle of an organism." [] +subset: 3_STAR +synonym: "growth regulators" RELATED [ChEBI] +is_a: CHEBI:24432 ! biological role + +[Term] +id: CHEBI:39410 +name: 1,2,4-triazines +namespace: chebi_ontology +def: "Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure." [] +subset: 3_STAR +xref: PMID:20194696 {source="Europe PMC"} +is_a: CHEBI:38102 ! triazines + +[Term] +id: CHEBI:39417 +name: branched-chain saturated fatty acid +namespace: chebi_ontology +def: "Any saturated fatty acid with a carbon side-chain or isopropyl termination." [] +subset: 3_STAR +synonym: "branched saturated fatty acid" RELATED [ChEBI] +synonym: "branched saturated fatty acids" RELATED [ChEBI] +synonym: "branched-chain saturated fatty acid" EXACT [ChEBI] +synonym: "branched-chain saturated fatty acids" RELATED [ChEBI] +is_a: CHEBI:26607 ! saturated fatty acid +is_a: CHEBI:35819 ! branched-chain fatty acid +relationship: is_conjugate_acid_of CHEBI:58956 ! branched-chain saturated fatty acid anion + [Term] id: CHEBI:39418 name: straight-chain saturated fatty acid @@ -15017,6 +25481,57 @@ def: "Any compound having a pyrimidine as part of its structure." [] subset: 3_STAR is_a: CHEBI:38313 ! diazines +[Term] +id: CHEBI:39548 +name: atorvastatin +namespace: chebi_ontology +alt_id: CHEBI:2910 +alt_id: CHEBI:39538 +def: "A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases." [] +subset: 3_STAR +synonym: "(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid" RELATED [ChemIDplus] +synonym: "7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID" RELATED [PDBeChem] +synonym: "Atorlip" RELATED BRAND_NAME [ChEBI] +synonym: "Atorvastatin" EXACT [KEGG_COMPOUND] +synonym: "atorvastatin" RELATED INN [ChemIDplus] +synonym: "atorvastatina" RELATED INN [ChEBI] +synonym: "atorvastatine" RELATED INN [ChEBI] +synonym: "atorvastatinum" RELATED INN [ChEBI] +xref: Beilstein:8373630 {source="Beilstein"} +xref: CAS:134523-00-5 {source="ChemIDplus"} +xref: CAS:134523-00-5 {source="KEGG COMPOUND"} +xref: Drug_Central:257 {source="DrugCentral"} +xref: DrugBank:DB01076 +xref: HMDB:HMDB0005006 +xref: KEGG:C06834 +xref: KEGG:D07474 +xref: LINCS:LSM-5771 +xref: Patent:EP409281 +xref: Patent:US5273995 +xref: PDBeChem:117 +xref: PMID:11693468 {source="Europe PMC"} +xref: PMID:15012735 {source="Europe PMC"} +xref: PMID:18720283 {source="Europe PMC"} +xref: Reaxys:8373630 {source="Reaxys"} +xref: Wikipedia:Atorvastatin +is_a: CHEBI:26455 ! pyrroles +is_a: CHEBI:35972 ! dihydroxy monocarboxylic acid +is_a: CHEBI:62733 ! aromatic amide +is_a: CHEBI:83575 ! monofluorobenzenes +is_a: CHEBI:87635 ! statin (synthetic) +relationship: has_functional_parent CHEBI:45571 ! heptanoic acid +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_acid_of CHEBI:50690 ! atorvastatin(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H35FN2O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUKUURHRXDUEBC-KAYWLYCHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "558.63988" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "558.25300" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(O)=O" xsd:string + [Term] id: CHEBI:39745 name: dihydrogenphosphate @@ -15057,6 +25572,306 @@ synonym: "cyclic ketones" EXACT IUPAC_NAME [IUPAC] xref: KEGG:C02019 is_a: CHEBI:17087 ! ketone +[Term] +id: CHEBI:4027 +name: cyclophosphamide +namespace: chebi_ontology +def: "A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom." [] +subset: 3_STAR +synonym: "(+-)-Cyclophosphamide" RELATED [ChemIDplus] +synonym: "(RS)-Cyclophosphamide" RELATED [ChemIDplus] +synonym: "2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide" RELATED [NIST_Chemistry_WebBook] +synonym: "Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester" RELATED [ChemIDplus] +synonym: "Cyclophosphamide anhydrous" RELATED [KEGG_COMPOUND] +synonym: "N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide" EXACT IUPAC_NAME [IUPAC] +synonym: "N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide" RELATED [IUPAC] +xref: Beilstein:11744 {source="Beilstein"} +xref: CAS:50-18-0 {source="NIST Chemistry WebBook"} +xref: CAS:50-18-0 {source="ChemIDplus"} +xref: CAS:50-18-0 {source="KEGG COMPOUND"} +xref: Drug_Central:758 {source="DrugCentral"} +xref: DrugBank:DB00531 +xref: HMDB:HMDB0014672 +xref: KEGG:C07888 +xref: KEGG:D07760 +xref: LINCS:LSM-4961 +xref: PMID:15711186 {source="Europe PMC"} +xref: PMID:7850793 {source="Europe PMC"} +xref: Reaxys:11744 {source="Reaxys"} +xref: Wikipedia:Cyclophosphamide +is_a: CHEBI:35467 ! phosphorodiamide +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:37598 ! nitrogen mustard +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:35842 ! antirheumatic drug +relationship: has_role CHEBI:50903 ! carcinogenic agent +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H15Cl2N2O2P" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CMSMOCZEIVJLDB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "261.08544" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "260.02482" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "ClCCN(CCCl)P1(=O)NCCCO1" xsd:string + +[Term] +id: CHEBI:40279 +name: allopurinol +namespace: chebi_ontology +alt_id: CHEBI:2601 +alt_id: CHEBI:40276 +def: "A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring." [] +subset: 3_STAR +synonym: "1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one" RELATED [ChemIDplus] +synonym: "1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one" RELATED [ChemIDplus] +synonym: "1H-Pyrazolo(3,4-d)pyrimidin-4-ol" RELATED [ChemIDplus] +synonym: "1H-pyrazolo[3,4-d]pyrimidin-4-ol" EXACT IUPAC_NAME [IUPAC] +synonym: "4'-Hydroxypyrazolol(3,4-d)pyrimidine" RELATED [ChemIDplus] +synonym: "4-HPP" RELATED [NIST_Chemistry_WebBook] +synonym: "4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine" RELATED [ChemIDplus] +synonym: "4-Hydroxy-3,4-pyrazolopyrimidine" RELATED [ChemIDplus] +synonym: "4-Hydroxypyrazolo(3,4-d)pyrimidine" RELATED [ChemIDplus] +synonym: "4-Hydroxypyrazolopyrimidine" RELATED [ChemIDplus] +synonym: "4-Hydroxypyrazolyl(3,4-d)pyrimidine" RELATED [ChemIDplus] +synonym: "4H-Pyrazolo(3,4-d)pyrimidin-4-one" RELATED [ChemIDplus] +synonym: "AL-100" RELATED [ChemIDplus] +synonym: "Allopurinol" EXACT [KEGG_DRUG] +synonym: "Allopurinolum" RELATED [ChemIDplus] +synonym: "Alopurinol" RELATED [ChemIDplus] +synonym: "Zyloprim (TN)" RELATED [KEGG_DRUG] +xref: Beilstein:608611 {source="Beilstein"} +xref: CAS:315-30-0 {source="NIST Chemistry WebBook"} +xref: CAS:315-30-0 {source="KEGG DRUG"} +xref: CAS:315-30-0 {source="ChemIDplus"} +xref: Drug_Central:124 {source="DrugCentral"} +xref: DrugBank:DB00437 +xref: KEGG:D00224 +xref: LINCS:LSM-5919 +xref: PMID:11333159 {source="Europe PMC"} +xref: PMID:16650385 {source="Europe PMC"} +xref: PMID:24395556 {source="Europe PMC"} +xref: PMID:24590210 {source="Europe PMC"} +xref: PMID:24591375 {source="Europe PMC"} +xref: PMID:7602118 {source="Europe PMC"} +xref: Reaxys:608611 {source="Reaxys"} +xref: Wikipedia:Allopurinol +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:67142 ! nucleobase analogue +relationship: has_parent_hydride CHEBI:50092 ! 1H-pyrazolo[4,3-d]pyrimidine +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35634 ! EC 1.17.3.2 (xanthine oxidase) inhibitor +relationship: has_role CHEBI:35845 ! gout suppressant +relationship: has_role CHEBI:48578 ! radical scavenger +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OFCNXPDARWKPPY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "136.11150" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "136.03851" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Oc1ncnc2[nH]ncc12" xsd:string + +[Term] +id: CHEBI:40303 +name: lovastatin +namespace: chebi_ontology +alt_id: CHEBI:40299 +alt_id: CHEBI:6544 +def: "A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom)." [] +subset: 3_STAR +synonym: "(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate" RELATED [ChemIDplus] +synonym: "(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone" RELATED [ChemIDplus] +synonym: "6alpha-methylcompactin" RELATED [ChemIDplus] +synonym: "LOVASTATIN" EXACT [PDBeChem] +synonym: "Lovastatin" EXACT [KEGG_COMPOUND] +synonym: "lovastatin" EXACT [UniProt] +synonym: "Mevacor" RELATED BRAND_NAME [ChemIDplus] +synonym: "Mevinolin" RELATED [ChemIDplus] +synonym: "MK-803" RELATED [KEGG_DRUG] +synonym: "ML-530B" RELATED [KEGG_DRUG] +xref: Beilstein:3631989 {source="ChemIDplus"} +xref: CAS:75330-75-5 {source="KEGG DRUG"} +xref: CAS:75330-75-5 {source="ChemIDplus"} +xref: Drug_Central:1612 {source="DrugCentral"} +xref: DrugBank:DB00227 +xref: HMDB:HMDB0014372 +xref: KEGG:C07074 +xref: KEGG:D00359 +xref: KNApSAcK:C00000547 +xref: LINCS:LSM-2189 +xref: Patent:CN103172602 +xref: Patent:WO2013090461 +xref: PDBeChem:803 +xref: PMID:11375168 {source="Europe PMC"} +xref: PMID:11389707 {source="Europe PMC"} +xref: PMID:11483865 {source="Europe PMC"} +xref: PMID:18642339 {source="Europe PMC"} +xref: PMID:24093797 {source="Europe PMC"} +xref: PMID:7720768 {source="Europe PMC"} +xref: Reaxys:4720754 {source="Reaxys"} +xref: Wikipedia:Lovastatin +is_a: CHEBI:142348 ! hexahydronaphthalenes +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:26188 ! polyketide +is_a: CHEBI:35748 ! fatty acid ester +is_a: CHEBI:87632 ! statin (naturally occurring) +relationship: has_functional_parent CHEBI:34848 ! mevastatin +relationship: has_functional_parent CHEBI:38655 ! (S)-2-methylbutyric acid +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:76956 ! Aspergillus metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H36O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PCZOHLXUXFIOCF-BXMDZJJMSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "404.53964" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "404.25627" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC" xsd:string + +[Term] +id: CHEBI:4031 +name: cyclosporin A +namespace: chebi_ontology +alt_id: CHEBI:63586 +alt_id: CHEBI:91802 +def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." [] +subset: 3_STAR +synonym: "(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)" RELATED [ChEBI] +synonym: "1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]" RELATED [JCBN] +synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" EXACT IUPAC_NAME [IUPAC] +synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" RELATED [ChEBI] +synonym: "Antibiotic S 7481F1" RELATED [ChemIDplus] +synonym: "Ciclosporin" RELATED [KEGG_COMPOUND] +synonym: "ciclosporin" RELATED INN [KEGG_DRUG] +synonym: "ciclosporina" RELATED INN [ChemIDplus] +synonym: "ciclosporine" RELATED INN [ChemIDplus] +synonym: "ciclosporinum" RELATED INN [ChemIDplus] +synonym: "Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)" RELATED [ChemIDplus] +synonym: "Cyclosporin A" EXACT [KEGG_COMPOUND] +synonym: "cyclosporin A" EXACT [UniProt] +synonym: "Cyclosporine" RELATED [ChemIDplus] +synonym: "Cyclosporine" RELATED [KEGG_COMPOUND] +synonym: "Gengraf" RELATED BRAND_NAME [DrugBank] +synonym: "Neoral" RELATED BRAND_NAME [DrugBank] +synonym: "Sandimmune" RELATED BRAND_NAME [DrugBank] +xref: Beilstein:3647785 {source="Beilstein"} +xref: CAS:59865-13-3 {source="ChemIDplus"} +xref: CAS:59865-13-3 {source="KEGG COMPOUND"} +xref: Chemspider:4447449 +xref: Drug_Central:760 {source="DrugCentral"} +xref: DrugBank:DB00091 +xref: HMDB:HMDB0250682 +xref: KEGG:C05086 +xref: KEGG:D00184 +xref: KNApSAcK:C00001517 +xref: LINCS:LSM-1703 +xref: LIPID_MAPS_instance:LMPK14000003 {source="LIPID MAPS"} +xref: MetaCyc:CPD-20532 +xref: Patent:US4117118 +xref: PMID:11058832 {source="Europe PMC"} +xref: PMID:11069928 {source="Europe PMC"} +xref: PMID:11079273 {source="Europe PMC"} +xref: PMID:11080188 {source="Europe PMC"} +xref: PMID:11238591 {source="Europe PMC"} +xref: PMID:11256490 {source="Europe PMC"} +xref: PMID:11278005 {source="Europe PMC"} +xref: PMID:11315347 {source="Europe PMC"} +xref: PMID:11370709 {source="Europe PMC"} +xref: PMID:11406057 {source="Europe PMC"} +xref: PMID:11426833 {source="Europe PMC"} +xref: PMID:11442023 {source="Europe PMC"} +xref: PMID:11481617 {source="Europe PMC"} +xref: PMID:11493684 {source="Europe PMC"} +xref: PMID:11529914 {source="Europe PMC"} +xref: PMID:11557554 {source="Europe PMC"} +xref: PMID:11564166 {source="Europe PMC"} +xref: PMID:11676831 {source="Europe PMC"} +xref: PMID:11870366 {source="Europe PMC"} +xref: PMID:12021257 {source="Europe PMC"} +xref: PMID:12050171 {source="Europe PMC"} +xref: PMID:12603598 {source="Europe PMC"} +xref: PMID:12761440 {source="Europe PMC"} +xref: PMID:12929192 {source="Europe PMC"} +xref: PMID:12950728 {source="Europe PMC"} +xref: PMID:14521916 {source="Europe PMC"} +xref: PMID:14621732 {source="Europe PMC"} +xref: PMID:14638917 {source="Europe PMC"} +xref: PMID:14672695 {source="Europe PMC"} +xref: PMID:14682659 {source="Europe PMC"} +xref: PMID:14743390 {source="Europe PMC"} +xref: PMID:15030555 {source="Europe PMC"} +xref: PMID:15175101 {source="Europe PMC"} +xref: PMID:15210365 {source="Europe PMC"} +xref: PMID:15306697 {source="Europe PMC"} +xref: PMID:15383526 {source="Europe PMC"} +xref: PMID:15541012 {source="Europe PMC"} +xref: PMID:15613074 {source="Europe PMC"} +xref: PMID:15626898 {source="Europe PMC"} +xref: PMID:15657176 {source="Europe PMC"} +xref: PMID:1566062 {source="Europe PMC"} +xref: PMID:15711594 {source="Europe PMC"} +xref: PMID:15811524 {source="Europe PMC"} +xref: PMID:15962181 {source="Europe PMC"} +xref: PMID:16372476 {source="Europe PMC"} +xref: PMID:16404634 {source="Europe PMC"} +xref: PMID:16724420 {source="Europe PMC"} +xref: PMID:16801218 {source="Europe PMC"} +xref: PMID:16898534 {source="Europe PMC"} +xref: PMID:17032751 {source="Europe PMC"} +xref: PMID:17083576 {source="Europe PMC"} +xref: PMID:17117422 {source="Europe PMC"} +xref: PMID:17192032 {source="Europe PMC"} +xref: PMID:17220244 {source="Europe PMC"} +xref: PMID:17229932 {source="Europe PMC"} +xref: PMID:17265451 {source="Europe PMC"} +xref: PMID:17446460 {source="Europe PMC"} +xref: PMID:17603747 {source="Europe PMC"} +xref: PMID:18076075 {source="Europe PMC"} +xref: PMID:18171316 {source="Europe PMC"} +xref: PMID:18191430 {source="Europe PMC"} +xref: PMID:18217899 {source="Europe PMC"} +xref: PMID:18259730 {source="Europe PMC"} +xref: PMID:18299432 {source="Europe PMC"} +xref: PMID:18359899 {source="Europe PMC"} +xref: PMID:18583716 {source="Europe PMC"} +xref: PMID:18597363 {source="Europe PMC"} +xref: PMID:18790203 {source="Europe PMC"} +xref: PMID:18818682 {source="Europe PMC"} +xref: PMID:18931077 {source="Europe PMC"} +xref: PMID:18975184 {source="Europe PMC"} +xref: PMID:19282398 {source="Europe PMC"} +xref: PMID:19589783 {source="Europe PMC"} +xref: PMID:21752960 {source="Europe PMC"} +xref: PMID:23620378 {source="Europe PMC"} +xref: PMID:24134630 {source="Europe PMC"} +xref: PMID:31144214 {source="Europe PMC"} +xref: PMID:34561200 {source="Europe PMC"} +xref: PMID:34561814 {source="Europe PMC"} +xref: Reaxys:3647785 {source="Reaxys"} +xref: VSDB:1765 +xref: Wikipedia:Ciclosporin +is_a: CHEBI:24613 ! homodetic cyclic peptide +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:25212 ! metabolite +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:35718 ! antifungal agent +relationship: has_role CHEBI:35842 ! antirheumatic drug +relationship: has_role CHEBI:37153 ! EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor +relationship: has_role CHEBI:49167 ! anti-asthmatic drug +relationship: has_role CHEBI:50177 ! dermatologic drug +relationship: has_role CHEBI:50903 ! carcinogenic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C62H111N11O12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PMATZTZNYRCHOR-CGLBZJNRSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1202.61120" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1201.84137" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\\C=C\\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C" xsd:string + [Term] id: CHEBI:40751 name: (S)-adrenaline @@ -15087,6 +25902,104 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "183.20446" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "183.08954" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CNC[C@@H](O)c1ccc(O)c(O)c1" xsd:string +[Term] +id: CHEBI:41308 +name: benzophenone +namespace: chebi_ontology +alt_id: CHEBI:3034 +alt_id: CHEBI:41306 +def: "The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups." [] +subset: 3_STAR +synonym: "alpha-oxodiphenylmethane" RELATED [NIST_Chemistry_WebBook] +synonym: "alpha-oxoditane" RELATED [NIST_Chemistry_WebBook] +synonym: "Benzophenone" EXACT [KEGG_COMPOUND] +synonym: "benzophenone" EXACT IUPAC_NAME [IUPAC] +synonym: "benzophenone" EXACT [UniProt] +synonym: "benzoylbenzene" RELATED [NIST_Chemistry_WebBook] +synonym: "Diphenyl ketone" RELATED [KEGG_COMPOUND] +synonym: "DIPHENYLMETHANONE" RELATED [PDBeChem] +synonym: "diphenylmethanone" EXACT IUPAC_NAME [IUPAC] +synonym: "Ph2CO" RELATED [ChEBI] +xref: Beilstein:1238185 {source="Beilstein"} +xref: CAS:119-61-9 {source="KEGG COMPOUND"} +xref: CAS:119-61-9 {source="NIST Chemistry WebBook"} +xref: CAS:119-61-9 {source="ChemIDplus"} +xref: Chemspider:2991 +xref: DrugBank:DB01878 +xref: Gmelin:4256 {source="Gmelin"} +xref: HMDB:HMDB0032049 +xref: KEGG:C06354 +xref: PDBeChem:BZQ +xref: PMID:10728861 {source="Europe PMC"} +xref: PMID:10864504 {source="Europe PMC"} +xref: PMID:10877357 {source="Europe PMC"} +xref: PMID:14673848 {source="Europe PMC"} +xref: PMID:15373829 {source="Europe PMC"} +xref: PMID:15672204 {source="Europe PMC"} +xref: PMID:16212356 {source="Europe PMC"} +xref: PMID:16820853 {source="Europe PMC"} +xref: PMID:16853025 {source="Europe PMC"} +xref: PMID:16999485 {source="Europe PMC"} +xref: PMID:17439666 {source="Europe PMC"} +xref: PMID:17955805 {source="Europe PMC"} +xref: PMID:19388040 {source="Europe PMC"} +xref: PMID:19655709 {source="Europe PMC"} +xref: PMID:19939518 {source="Europe PMC"} +xref: PMID:20534002 {source="Europe PMC"} +xref: PMID:21238557 {source="Europe PMC"} +xref: PMID:21277784 {source="Europe PMC"} +xref: PMID:21919502 {source="Europe PMC"} +xref: PMID:23963450 {source="Europe PMC"} +xref: PMID:24226914 {source="Europe PMC"} +xref: PMID:25788150 {source="Europe PMC"} +xref: PMID:26254646 {source="Europe PMC"} +xref: PMID:26282042 {source="Europe PMC"} +xref: PMID:30720459 {source="Europe PMC"} +xref: PMID:32736220 {source="Europe PMC"} +xref: PMID:33682414 {source="Europe PMC"} +xref: Reaxys:1238185 {source="Reaxys"} +xref: Wikipedia:Benzophenone +is_a: CHEBI:22726 ! benzophenones +relationship: has_role CHEBI:47868 ! photosensitizing agent +relationship: has_role CHEBI:76924 ! plant metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H10O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RWCCWEUUXYIKHB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "182.222" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "182.07316" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C(C1=CC=CC=C1)C1=CC=CC=C1" xsd:string + +[Term] +id: CHEBI:41550 +name: fluoroform +namespace: chebi_ontology +alt_id: CHEBI:24073 +alt_id: CHEBI:41543 +subset: 3_STAR +synonym: "carbon trifluoride" RELATED [UM-BBD] +synonym: "CHF3" RELATED [IUPAC] +synonym: "fluoroform" EXACT IUPAC_NAME [IUPAC] +synonym: "Freon 23" RELATED [ChemIDplus] +synonym: "Freon F-23" RELATED [NIST_Chemistry_WebBook] +synonym: "methyl trifluoride" RELATED [NIST_Chemistry_WebBook] +synonym: "TRIFLUOROMETHANE" RELATED [PDBeChem] +xref: Beilstein:1731035 {source="Beilstein"} +xref: CAS:75-46-7 {source="NIST Chemistry WebBook"} +xref: CAS:75-46-7 {source="ChemIDplus"} +xref: Gmelin:1543 {source="Gmelin"} +xref: PDBeChem:CFT +xref: UM-BBD_compID:c0802 {source="UM-BBD"} +is_a: CHEBI:39281 ! fluoromethanes +relationship: has_role CHEBI:78433 ! refrigerant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHF3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CHF3/c2-1(3)4/h1H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XPDWGBQVDMORPB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "70.01385" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "70.00303" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C(F)(F)F" xsd:string + [Term] id: CHEBI:41609 name: carbonate @@ -15114,6 +26027,232 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "60.00890" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.98584" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([O-])=O" xsd:string +[Term] +id: CHEBI:4167 +name: D-glucopyranose +namespace: chebi_ontology +def: "A glucopyranose having D-configuration." [] +subset: 3_STAR +synonym: "D-Glc" RELATED [ChEBI] +synonym: "D-Glcp" RELATED [ChEBI] +synonym: "D-glucopyranose" EXACT IUPAC_NAME [IUPAC] +synonym: "D-Glucose" RELATED [KEGG_COMPOUND] +synonym: "D-glucose" RELATED [UniProt] +synonym: "Dextrose" RELATED [KEGG_COMPOUND] +synonym: "Glc-OH" RELATED [ChEBI] +synonym: "Glucose" RELATED [KEGG_COMPOUND] +synonym: "glucose" RELATED [ChEBI] +synonym: "Grape sugar" RELATED [KEGG_COMPOUND] +synonym: "WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/" RELATED [GlyTouCan] +xref: Beilstein:1281604 {source="Beilstein"} +xref: CAS:2280-44-6 {source="ChemIDplus"} +xref: GlyGen:G15021LG +xref: GlyTouCan:G15021LG +xref: Gmelin:83256 {source="Gmelin"} +xref: HMDB:HMDB0000122 +xref: KEGG:C00031 +xref: KEGG:D00009 +xref: KNApSAcK:C00001122 +xref: MetaCyc:D-Glucose +xref: PMID:15987845 {source="Europe PMC"} +xref: PMID:16901854 {source="Europe PMC"} +xref: PMID:17336832 {source="Europe PMC"} +xref: PMID:17439666 {source="Europe PMC"} +xref: PMID:17928662 {source="Europe PMC"} +xref: PMID:19913595 {source="Europe PMC"} +xref: PMID:26812026 {source="Europe PMC"} +xref: PMID:32619908 {source="Europe PMC"} +xref: PMID:7524207 {source="Europe PMC"} +xref: PMID:9140037 {source="Europe PMC"} +xref: PMID:9501190 {source="Europe PMC"} +xref: PMID:9506998 {source="Europe PMC"} +xref: PMID:9545565 {source="Europe PMC"} +xref: Reaxys:1281604 {source="Reaxys"} +xref: Wikipedia:Glucose +is_a: CHEBI:17634 ! D-glucose +is_a: CHEBI:37661 ! glucopyranose +relationship: has_role CHEBI:75771 ! mouse metabolite +relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite +relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +relationship: has_role CHEBI:77746 ! human metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WQZGKKKJIJFFOK-GASJEMHNSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O" xsd:string + +[Term] +id: CHEBI:41774 +name: tamoxifen +namespace: chebi_ontology +alt_id: CHEBI:41767 +alt_id: CHEBI:9396 +subset: 3_STAR +synonym: "(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine" RELATED [ChemIDplus] +synonym: "(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine" RELATED [ChemIDplus] +synonym: "1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene" RELATED [ChemIDplus] +synonym: "1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene" RELATED [ChemIDplus] +synonym: "2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine" EXACT IUPAC_NAME [IUPAC] +synonym: "Apo-Tamox" RELATED BRAND_NAME [DrugBank] +synonym: "Crisafeno" RELATED BRAND_NAME [DrugBank] +synonym: "Diemon" RELATED BRAND_NAME [DrugBank] +synonym: "Tamoxifen" EXACT [KEGG_COMPOUND] +synonym: "tamoxifen" RELATED INN [ChemIDplus] +synonym: "tamoxifene" RELATED INN [ChemIDplus] +synonym: "tamoxifeno" RELATED INN [ChemIDplus] +synonym: "tamoxifenum" RELATED INN [ChemIDplus] +synonym: "trans-Tamoxifen" RELATED [ChemIDplus] +xref: Beilstein:2062020 {source="Beilstein"} +xref: CAS:10540-29-1 {source="ChemIDplus"} +xref: CAS:10540-29-1 {source="KEGG COMPOUND"} +xref: Drug_Central:2561 {source="DrugCentral"} +xref: DrugBank:DB00675 +xref: HMDB:HMDB0014813 +xref: KEGG:C07108 +xref: KEGG:D08559 +xref: Patent:BE637389 +xref: Patent:BE678807 +xref: Patent:US4536516 +xref: PMID:14681337 {source="Europe PMC"} +xref: PMID:14709804 {source="Europe PMC"} +xref: PMID:18348622 {source="Europe PMC"} +xref: PMID:7688593 {source="Europe PMC"} +xref: Wikipedia:Tamoxifen +is_a: CHEBI:26776 ! stilbenoid +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_parent_hydride CHEBI:26775 ! stilbene +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:37700 ! EC 2.7.11.13 (protein kinase C) inhibitor +relationship: has_role CHEBI:48422 ! angiogenesis inhibitor +relationship: has_role CHEBI:50646 ! bone density conservation agent +relationship: has_role CHEBI:50739 ! estrogen receptor modulator +relationship: has_role CHEBI:50792 ! estrogen receptor antagonist +relationship: has_role CHEBI:50837 ! estrogen antagonist +relationship: has_role CHEBI:62872 ! EC 1.2.3.1 (aldehyde oxidase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H29NO" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NKANXQFJJICGDU-QPLCGJKRSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "371.51460" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "371.22491" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC\\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1" xsd:string + +[Term] +id: CHEBI:41879 +name: dexamethasone +namespace: chebi_ontology +alt_id: CHEBI:41873 +alt_id: CHEBI:4461 +def: "A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids." [] +subset: 3_STAR +synonym: "(11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione" RELATED [ChemIDplus] +synonym: "1-dehydro-16alpha-methyl-9alpha-fluorohydrocortisone" RELATED [NIST_Chemistry_WebBook] +synonym: "16alpha-methyl-9alpha-fluoro-1-dehydrocortisol" RELATED [NIST_Chemistry_WebBook] +synonym: "9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "9alpha-fluoro-16alpha-methylprednisolone" RELATED [NIST_Chemistry_WebBook] +synonym: "Aeroseb-Dex" RELATED BRAND_NAME [ChemIDplus] +synonym: "Auxiron" RELATED BRAND_NAME [ChemIDplus] +synonym: "Azium" RELATED BRAND_NAME [ChemIDplus] +synonym: "Calonat" RELATED BRAND_NAME [ChemIDplus] +synonym: "Corson" RELATED BRAND_NAME [ChEBI] +synonym: "Cortisumman" RELATED BRAND_NAME [ChemIDplus] +synonym: "Decacort" RELATED BRAND_NAME [ChEBI] +synonym: "Decadron" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Decaject" RELATED BRAND_NAME [ChemIDplus] +synonym: "Decalix" RELATED BRAND_NAME [ChemIDplus] +synonym: "Decameth" RELATED BRAND_NAME [ChemIDplus] +synonym: "Dexacortal" RELATED BRAND_NAME [ChemIDplus] +synonym: "Dexacortin" RELATED BRAND_NAME [ChemIDplus] +synonym: "dexametasona" RELATED INN [WHO_MedNet] +synonym: "Dexamethasone" EXACT [KEGG_DRUG] +synonym: "dexamethasone" EXACT [UniProt] +synonym: "dexamethasone" RELATED INN [WHO_MedNet] +synonym: "dexamethasonum" RELATED INN [WHO_MedNet] +synonym: "Dexason" RELATED BRAND_NAME [ChemIDplus] +synonym: "Dexasone" RELATED BRAND_NAME [ChemIDplus] +synonym: "DexPak" RELATED BRAND_NAME [ChemIDplus] +synonym: "Diodex" RELATED BRAND_NAME [ChEBI] +synonym: "fluormethylprednisolone" RELATED [VSDB] +synonym: "Hexadrol" RELATED BRAND_NAME [ChemIDplus] +synonym: "Maxidex" RELATED BRAND_NAME [ChemIDplus] +synonym: "Millicorten" RELATED BRAND_NAME [ChemIDplus] +synonym: "Oradexon" RELATED BRAND_NAME [ChemIDplus] +synonym: "Ozurdex" RELATED BRAND_NAME [ChEBI] +synonym: "Solurex" RELATED BRAND_NAME [ChEBI] +synonym: "Zema-Pak" RELATED BRAND_NAME [ChEBI] +xref: Beilstein:2066652 {source="Beilstein"} +xref: CAS:50-02-2 {source="ChemIDplus"} +xref: CAS:50-02-2 {source="NIST Chemistry WebBook"} +xref: Drug_Central:824 {source="DrugCentral"} +xref: DrugBank:DB01234 +xref: FooDB:FDB001355 +xref: HMDB:HMDB0015364 +xref: KEGG:C15643 +xref: KEGG:D00292 +xref: MetaCyc:CPD-10549 +xref: Patent:DE1113690 +xref: Patent:GB869511 +xref: Patent:US3007923 +xref: PMID:11508649 {source="Europe PMC"} +xref: PMID:12151000 {source="Europe PMC"} +xref: PMID:12686538 {source="Europe PMC"} +xref: PMID:18272184 {source="Europe PMC"} +xref: PMID:18524938 {source="Europe PMC"} +xref: PMID:19779450 {source="Europe PMC"} +xref: PMID:20850457 {source="Europe PMC"} +xref: PMID:26602186 {source="Europe PMC"} +xref: PMID:29958267 {source="Europe PMC"} +xref: PMID:31391291 {source="Europe PMC"} +xref: PMID:32195984 {source="Europe PMC"} +xref: PMID:32280693 {source="Europe PMC"} +xref: PMID:32496907 {source="Europe PMC"} +xref: PMID:32551464 {source="Europe PMC"} +xref: PMID:32570995 {source="Europe PMC"} +xref: Reaxys:2066652 {source="Reaxys"} +xref: VSDB:1769 +xref: Wikipedia:Dexamethasone +is_a: CHEBI:24261 ! glucocorticoid +is_a: CHEBI:35342 ! 17alpha-hydroxy steroid +is_a: CHEBI:35344 ! 21-hydroxy steroid +is_a: CHEBI:35346 ! 11beta-hydroxy steroid +is_a: CHEBI:36885 ! 20-oxo steroid +is_a: CHEBI:50830 ! fluorinated steroid +is_a: CHEBI:77166 ! 3-oxo-Delta(1),Delta(4)-steroid +relationship: has_parent_hydride CHEBI:8386 ! pregnane +relationship: has_role CHEBI:35472 ! anti-inflammatory drug +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:37962 ! adrenergic agent +relationship: has_role CHEBI:50919 ! antiemetic +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H29FO5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UREBDLICKHMUKA-CXSFZGCWSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "392.467" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "392.19990" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(C=C2[C@]1([C@@]3([C@@](CC2)([C@]4([C@](C[C@@H]3O)([C@]([C@@H](C4)C)(C(CO)=O)O)C)[H])[H])F)C)=O" xsd:string + +[Term] +id: CHEBI:4194 +name: D-hexose +namespace: chebi_ontology +def: "A hexose that has D-configuration at position 5." [] +subset: 3_STAR +synonym: "D-hexopyranose" EXACT IUPAC_NAME [IUPAC] +synonym: "D-Hexose" EXACT [KEGG_COMPOUND] +synonym: "D-hexose" EXACT [UniProt] +synonym: "D-hexoses" RELATED [ChEBI] +xref: KEGG:C00738 +is_a: CHEBI:18133 ! hexose +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "180.156" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string + [Term] id: CHEBI:42111 name: (R)-lactic acid @@ -15161,6 +26300,58 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "90.07794" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "90.03169" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](O)C(O)=O" xsd:string +[Term] +id: CHEBI:421707 +name: abacavir +namespace: chebi_ontology +alt_id: CHEBI:193608 +alt_id: CHEBI:2360 +alt_id: CHEBI:441792 +alt_id: CHEBI:520984 +alt_id: CHEBI:525912 +def: "A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection." [] +subset: 3_STAR +synonym: "Abacavir" EXACT [KEGG_COMPOUND] +synonym: "abacavir" RELATED INN [ChemIDplus] +synonym: "ABC" RELATED [ChEBI] +synonym: "{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol" EXACT IUPAC_NAME [IUPAC] +synonym: "{(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol" RELATED [ChEBI] +xref: Beilstein:7493116 {source="Beilstein"} +xref: CAS:136470-78-5 {source="KEGG COMPOUND"} +xref: CAS:136470-78-5 {source="ChemIDplus"} +xref: Drug_Central:34 {source="DrugCentral"} +xref: DrugBank:DB01048 +xref: KEGG:C07624 +xref: KEGG:D07057 +xref: PMID:11678376 {source="Europe PMC"} +xref: PMID:11806176 {source="Europe PMC"} +xref: PMID:12781181 {source="ChEMBL"} +xref: PMID:15887959 {source="ChEMBL"} +xref: PMID:16458506 {source="ChEMBL"} +xref: PMID:16539393 {source="ChEMBL"} +xref: PMID:16759112 {source="ChEMBL"} +xref: PMID:17172311 {source="ChEMBL"} +xref: PMID:17870541 {source="ChEMBL"} +xref: PMID:18029175 {source="ChEMBL"} +xref: PMID:18549801 {source="Europe PMC"} +xref: PMID:24751900 {source="Europe PMC"} +xref: PMID:25017682 {source="Europe PMC"} +xref: PMID:25674793 {source="Europe PMC"} +xref: PMID:26024233 {source="Europe PMC"} +xref: Reaxys:7493116 {source="Reaxys"} +xref: Wikipedia:Abacavir +is_a: CHEBI:38001 ! 2,6-diaminopurines +relationship: has_role CHEBI:36044 ! antiviral drug +relationship: has_role CHEBI:53756 ! HIV-1 reverse transcriptase inhibitor +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H18N6O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MCGSCOLBFJQGHM-SCZZXKLOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "286.339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "286.15421" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=12N(C=NC1C(NC3CC3)=NC(=N2)N)[C@H]4C=C[C@H](C4)CO" xsd:string + [Term] id: CHEBI:422 name: (S)-lactic acid @@ -15279,6 +26470,36 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "242.39750" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "242.22458" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCCCC(O)=O" xsd:string +[Term] +id: CHEBI:42724 +name: (R)-amphetamine +namespace: chebi_ontology +alt_id: CHEBI:35339 +alt_id: CHEBI:42720 +def: "A 1-phenylpropan-2-amine that has R configuration." [] +subset: 3_STAR +synonym: "(-)-amphetamine" RELATED [ChemIDplus] +synonym: "(-)-phenylisopropylamine" RELATED [ChemIDplus] +synonym: "(2R)-1-phenylpropan-2-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "(R)-alpha-methylbenzeneethanamine" RELATED [ChemIDplus] +synonym: "(R)-alpha-methylphenethylamine" RELATED [ChemIDplus] +synonym: "(R)-amphetamine" EXACT [ChemIDplus] +synonym: "levamfetamine" RELATED [ChemIDplus] +synonym: "levamphetamine" RELATED [ChemIDplus] +xref: Beilstein:2432739 {source="Beilstein"} +xref: CAS:156-34-3 {source="ChemIDplus"} +xref: Drug_Central:1562 {source="DrugCentral"} +xref: Gmelin:1125855 {source="Gmelin"} +is_a: CHEBI:132233 ! 1-phenylpropan-2-amine +relationship: is_enantiomer_of CHEBI:4469 ! (S)-amphetamine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KWTSXDURSIMDCE-MRVPVSSYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "135.20626" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.10480" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](N)Cc1ccccc1" xsd:string + [Term] id: CHEBI:43176 name: hydroxy group @@ -15300,6 +26521,14 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "17.00734" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*O[H]" xsd:string +[Term] +id: CHEBI:43254 +name: (4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:38337 ! pyrimidone +relationship: is_tautomer_of CHEBI:17568 ! uracil + [Term] id: CHEBI:43474 name: hydrogenphosphate @@ -15338,6 +26567,289 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "95.97930" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.96234" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP([O-])([O-])=O" xsd:string +[Term] +id: CHEBI:43966 +name: melagatran +namespace: chebi_ontology +alt_id: CHEBI:73114 +def: "A member of the class of azetidines that is (2S)-azetidine 2-carboxylic acid in which the carboxylic acid has been converted to the amide corresponding to formal condensation with 4-(aminomethyl)benzenecarboximidamide and in which the hydrogen attached to the azetidine nitrogen is replaced by a (2R)-2-cyclohexyl-2-[(carboxymethyl)amino]acetyl group." [] +subset: 3_STAR +synonym: "melagatran" RELATED INN [WHO_MedNet] +synonym: "melagatran" RELATED INN [ChemIDplus] +synonym: "melagatranum" RELATED INN [WHO_MedNet] +synonym: "N-((R)-(((2S)-2-((-p-amidobenzyl)carbamoyl)-1-azetidinyl)carbonyl)cyclohexylmethyl)glycine" RELATED [ChemIDplus] +synonym: "N-[(1R)-2-{(2S)-2-[(4-carbamimidoylbenzyl)carbamoyl]azetidin-1-yl}-1-cyclohexyl-2-oxoethyl]glycine" EXACT IUPAC_NAME [IUPAC] +xref: CAS:159776-70-2 {source="KEGG DRUG"} +xref: CAS:159776-70-2 {source="ChemIDplus"} +xref: KEGG:D07143 +xref: PDBeChem:MEL +xref: PMID:10102460 {source="Europe PMC"} +xref: PMID:11060733 {source="Europe PMC"} +xref: PMID:12846595 {source="Europe PMC"} +xref: PMID:13680847 {source="Europe PMC"} +xref: PMID:15487959 {source="Europe PMC"} +xref: PMID:16106594 {source="Europe PMC"} +xref: PMID:16123912 {source="Europe PMC"} +xref: PMID:16767816 {source="Europe PMC"} +xref: PMID:22546231 {source="Europe PMC"} +xref: PMID:28338626 {source="Europe PMC"} +xref: PMID:9459334 {source="Europe PMC"} +xref: Reaxys:8090770 {source="Reaxys"} +is_a: CHEBI:35359 ! carboxamidine +is_a: CHEBI:35735 ! dicarboxylic acid monoamide +is_a: CHEBI:38777 ! azetidines +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:64926 ! serine protease inhibitor +relationship: has_role CHEBI:65232 ! EC 3.4.21.5 (thrombin) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H31N5O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DKWNMCUOEDMMIN-PKOBYXMFSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "429.51260" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "429.23760" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(CCN1C(=O)[C@H](NCC(O)=O)C1CCCCC1)C(=O)NCc1ccc(cc1)C(N)=N" xsd:string + +[Term] +id: CHEBI:44185 +name: methotrexate +namespace: chebi_ontology +alt_id: CHEBI:44183 +alt_id: CHEBI:6837 +subset: 3_STAR +synonym: "4-amino-10-methylfolic acid" RELATED [ChemIDplus] +synonym: "4-amino-N(10)-methylpteroylglutamic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Emtexate" RELATED BRAND_NAME [DrugBank] +synonym: "Ledertrexate" RELATED BRAND_NAME [DrugBank] +synonym: "METHOTREXATE" EXACT [PDBeChem] +synonym: "Methotrexate" EXACT [KEGG_COMPOUND] +synonym: "methotrexate" RELATED INN [KEGG_DRUG] +synonym: "methotrexatum" RELATED INN [ChemIDplus] +synonym: "metotrexato" RELATED INN [ChemIDplus] +synonym: "MTX" RELATED [ChemIDplus] +synonym: "N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Rheumatrex" RELATED BRAND_NAME [DrugBank] +synonym: "Trexall" RELATED BRAND_NAME [DrugBank] +xref: Beilstein:70669 {source="Beilstein"} +xref: CAS:59-05-2 {source="ChemIDplus"} +xref: CAS:59-05-2 {source="NIST Chemistry WebBook"} +xref: CAS:59-05-2 {source="KEGG COMPOUND"} +xref: Drug_Central:1751 {source="DrugCentral"} +xref: DrugBank:DB00563 +xref: KEGG:C01937 +xref: KEGG:D00142 +xref: LINCS:LSM-5690 +xref: Patent:US2512572 +xref: PDBeChem:MTX +xref: Wikipedia:Methotrexate +is_a: CHEBI:26373 ! pteridines +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:35692 ! dicarboxylic acid +relationship: has_functional_parent CHEBI:16015 ! L-glutamic acid +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:35842 ! antirheumatic drug +relationship: has_role CHEBI:50177 ! dermatologic drug +relationship: has_role CHEBI:50683 ! EC 1.5.1.3 (dihydrofolate reductase) inhibitor +relationship: has_role CHEBI:50691 ! abortifacient +relationship: has_role CHEBI:59517 ! DNA synthesis inhibitor +relationship: is_conjugate_acid_of CHEBI:50680 ! methotrexate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H22N8O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOZXECLQNJBKD-ZDUSSCGKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "454.43960" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "454.17132" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O" xsd:string + +[Term] +id: CHEBI:4469 +name: (S)-amphetamine +namespace: chebi_ontology +def: "A 1-phenylpropan-2-amine that has S configuration." [] +subset: 3_STAR +synonym: "(+)-(S)-amphetamine" RELATED [ChemIDplus] +synonym: "(+)-alpha-methylphenethylamine" RELATED [NIST_Chemistry_WebBook] +synonym: "(+)-alpha-methylphenylethylamine" RELATED [NIST_Chemistry_WebBook] +synonym: "(+)-amphetamine" RELATED [ChEBI] +synonym: "(2S)-1-phenylpropan-2-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "(alphaS)-alpha-methylbenzeneethanamine" RELATED [ChemIDplus] +synonym: "(S)-(+)-amphetamine" RELATED [ChemIDplus] +synonym: "(S)-(+)-beta-phenylisopropylamine" RELATED [NIST_Chemistry_WebBook] +synonym: "(S)-1-phenyl-2-aminopropane" RELATED [ChemIDplus] +synonym: "(S)-1-phenyl-2-propylamine" RELATED [ChemIDplus] +synonym: "(S)-alpha-methylbenzeneethanamine" RELATED [ChemIDplus] +synonym: "(S)-amphetamine" EXACT [NIST_Chemistry_WebBook] +synonym: "d-amphetamine" RELATED [ChemIDplus] +synonym: "dexamphetamine" RELATED [NIST_Chemistry_WebBook] +synonym: "Dextroamphetamine" RELATED [KEGG_COMPOUND] +xref: Beilstein:2205872 {source="ChemIDplus"} +xref: CAS:51-64-9 {source="ChemIDplus"} +xref: CAS:51-64-9 {source="KEGG COMPOUND"} +xref: CAS:51-64-9 {source="NIST Chemistry WebBook"} +xref: Drug_Central:841 {source="DrugCentral"} +xref: DrugBank:DB01576 +xref: Gmelin:1125854 {source="Gmelin"} +xref: KEGG:C07884 +xref: KEGG:D03740 +xref: PMID:22129527 {source="Europe PMC"} +xref: PMID:22894820 {source="Europe PMC"} +xref: PMID:23360956 {source="Europe PMC"} +xref: PMID:23851485 {source="Europe PMC"} +xref: PMID:23881044 {source="Europe PMC"} +xref: PMID:23907377 {source="Europe PMC"} +xref: PMID:24349338 {source="Europe PMC"} +xref: Wikipedia:Dextroamphetamine +is_a: CHEBI:132233 ! 1-phenylpropan-2-amine +relationship: has_role CHEBI:35524 ! sympathomimetic agent +relationship: has_role CHEBI:35640 ! adrenergic uptake inhibitor +relationship: has_role CHEBI:50910 ! neurotoxin +relationship: has_role CHEBI:51039 ! dopamine uptake inhibitor +relationship: is_enantiomer_of CHEBI:42724 ! (R)-amphetamine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KWTSXDURSIMDCE-QMMMGPOBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "135.20626" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.10480" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](N)Cc1ccccc1" xsd:string + +[Term] +id: CHEBI:45373 +name: sulfanilamide +namespace: chebi_ontology +alt_id: CHEBI:45370 +alt_id: CHEBI:9333 +def: "A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position." [] +subset: 3_STAR +synonym: "4-aminobenzene sulfonic acid amide" RELATED [ChEBI] +synonym: "4-aminobenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "4-azanylbenzenesulfonamide" RELATED [IUPAC] +synonym: "p-aminobenzenesulfamide" RELATED [NIST_Chemistry_WebBook] +synonym: "p-aminobenzenesulfonamide" RELATED [NIST_Chemistry_WebBook] +synonym: "para-aminobenzenesulfonamide" RELATED [ChEBI] +synonym: "Prontosil album" RELATED [KEGG_COMPOUND] +synonym: "SA" RELATED [ChEBI] +synonym: "Streptocide" RELATED [NIST_Chemistry_WebBook] +synonym: "Sulfamine" RELATED [KEGG_COMPOUND] +synonym: "sulfamine" RELATED [NIST_Chemistry_WebBook] +synonym: "SULFANILAMIDE" EXACT [PDBeChem] +synonym: "Sulfanilamide" EXACT [KEGG_COMPOUND] +synonym: "sulphanilamide" RELATED [ChEBI] +xref: Beilstein:511852 {source="Beilstein"} +xref: CAS:63-74-1 {source="NIST Chemistry WebBook"} +xref: CAS:63-74-1 {source="KEGG COMPOUND"} +xref: CAS:63-74-1 {source="ChemIDplus"} +xref: Drug_Central:2521 {source="DrugCentral"} +xref: DrugBank:DB00259 +xref: Gmelin:83068 {source="Gmelin"} +xref: HMDB:HMDB0014404 +xref: KEGG:C07458 +xref: KEGG:D08543 +xref: LINCS:LSM-6524 +xref: PDBeChem:SAN +xref: PMID:22214209 {source="Europe PMC"} +xref: PMID:22342371 {source="Europe PMC"} +xref: PMID:22974493 {source="Europe PMC"} +xref: PMID:23061287 {source="Europe PMC"} +xref: PMID:23065453 {source="Europe PMC"} +xref: PMID:23122138 {source="Europe PMC"} +xref: PMID:23294218 {source="Europe PMC"} +xref: PMID:23476893 {source="Europe PMC"} +xref: PMID:23561569 {source="Europe PMC"} +xref: PMID:2420897 {source="Europe PMC"} +xref: PMID:9639594 {source="Europe PMC"} +xref: Reaxys:511852 {source="Reaxys"} +xref: VSDB:1924 +xref: Wikipedia:Sulfanilamide +is_a: CHEBI:48975 ! substituted aniline +is_a: CHEBI:87228 ! sulfonamide antibiotic +relationship: has_role CHEBI:23018 ! EC 4.2.1.1 (carbonic anhydrase) inhibitor +relationship: has_role CHEBI:33282 ! antibacterial agent +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8N2O2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FDDDEECHVMSUSB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "172.20600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "172.03065" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1ccc(cc1)S(N)(=O)=O" xsd:string + +[Term] +id: CHEBI:45525 +name: (R)-2-methylbutyric acid +namespace: chebi_ontology +alt_id: CHEBI:38654 +alt_id: CHEBI:45523 +def: "The (R)-enantiomer of 2-methylbutanoic acid." [] +subset: 3_STAR +synonym: "(2R)-2-methylbutanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "(2R)-2-methylbutyric acid" RELATED [ChEBI] +synonym: "2-METHYLBUTANOIC ACID" RELATED [PDBeChem] +xref: Beilstein:1720484 {source="Beilstein"} +xref: Gmelin:1041646 {source="Gmelin"} +xref: PDBeChem:SMB +xref: PMID:2026560 {source="Europe PMC"} +is_a: CHEBI:37070 ! 2-methylbutyric acid +relationship: is_enantiomer_of CHEBI:38655 ! (S)-2-methylbutyric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H10O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/t4-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLAMNBDJUVNPJU-SCSAIBSYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "102.13170" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "102.06808" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[C@@H](C)C(O)=O" xsd:string + +[Term] +id: CHEBI:45571 +name: heptanoic acid +namespace: chebi_ontology +alt_id: CHEBI:24519 +alt_id: CHEBI:45568 +def: "A C7, straight-chain fatty acid that contributes to the odour of some rancid oils. Used in the preparation of esters for the fragrance industry, and as an additive in cigarettes." [] +subset: 3_STAR +synonym: "CH3-[CH2]5-COOH" RELATED [IUPAC] +synonym: "enanthic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "enanthylic acid" RELATED [ChemIDplus] +synonym: "HEPTANOIC ACID" EXACT [PDBeChem] +synonym: "heptanoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "Heptansaeure" RELATED [ChEBI] +synonym: "heptoic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "heptylic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "n-heptanoic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "n-heptoic acid" RELATED [ChemIDplus] +synonym: "n-heptylic acid" RELATED [ChemIDplus] +synonym: "oenanthic acid" RELATED [ChemIDplus] +synonym: "Oenanthsaeure" RELATED [ChemIDplus] +synonym: "oenanthylic acid" RELATED [ChemIDplus] +xref: Beilstein:1744723 {source="Beilstein"} +xref: CAS:111-14-8 {source="ChemIDplus"} +xref: CAS:111-14-8 {source="NIST Chemistry WebBook"} +xref: CAS:111-14-8 {source="KEGG COMPOUND"} +xref: DrugBank:DB02938 +xref: Gmelin:142428 {source="Gmelin"} +xref: HMDB:HMDB0000666 +xref: KEGG:C17714 +xref: LIPID_MAPS_instance:LMFA01010007 {source="LIPID MAPS"} +xref: MetaCyc:CPD-7619 +xref: PDBeChem:SHV +xref: PMID:23999410 {source="Europe PMC"} +xref: Reaxys:1744723 {source="Reaxys"} +xref: Wikipedia:Heptanoic_acid +is_a: CHEBI:39418 ! straight-chain saturated fatty acid +is_a: CHEBI:59554 ! medium-chain fatty acid +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_acid_of CHEBI:32362 ! heptanoate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H14O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H14O2/c1-2-3-4-5-6-7(8)9/h2-6H2,1H3,(H,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MNWFXJYAOYHMED-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "130.18486" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.09938" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCC(O)=O" xsd:string + [Term] id: CHEBI:45696 name: hydrogensulfate @@ -15366,6 +26878,144 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "97.07154" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS([O-])(=O)=O" xsd:string +[Term] +id: CHEBI:45863 +name: paclitaxel +namespace: chebi_ontology +alt_id: CHEBI:45862 +alt_id: CHEBI:7887 +def: "A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark." [] +subset: 3_STAR +synonym: "(2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester" RELATED [ChemIDplus] +synonym: "4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate" EXACT IUPAC_NAME [IUPAC] +synonym: "5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine" RELATED [ChemIDplus] +synonym: "Paclitaxel" EXACT [KEGG_COMPOUND] +synonym: "TAXOL" RELATED [PDBeChem] +synonym: "taxol" RELATED [UniProt] +synonym: "Taxol A" RELATED [ChemIDplus] +xref: CAS:33069-62-4 {source="ChemIDplus"} +xref: CAS:33069-62-4 {source="KEGG COMPOUND"} +xref: Drug_Central:2044 {source="DrugCentral"} +xref: DrugBank:DB01229 +xref: KEGG:C07394 +xref: KEGG:D00491 +xref: KNApSAcK:C00002365 +xref: PDBeChem:TA1 +xref: Wikipedia:Paclitaxel +is_a: CHEBI:50367 ! taxane diterpenoid +is_a: CHEBI:52557 ! tetracyclic diterpenoid +relationship: has_functional_parent CHEBI:32898 ! baccatin III +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:61950 ! microtubule-stabilising agent +relationship: has_role CHEBI:77746 ! human metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C47H51NO14" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RCINICONZNJXQF-MZXODVADSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "853.90618" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "853.33096" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C" xsd:string + +[Term] +id: CHEBI:46345 +name: 5-fluorouracil +namespace: chebi_ontology +alt_id: CHEBI:2054 +alt_id: CHEBI:46343 +def: "A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth." [] +subset: 3_STAR +synonym: "5-Fluoracil" RELATED [ChemIDplus] +synonym: "5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "5-Fluoropyrimidine-2,4-dione" RELATED [ChemIDplus] +synonym: "5-Fluorouracil" EXACT [KEGG_COMPOUND] +synonym: "5-fluorouracil" EXACT IUPAC_NAME [IUPAC] +synonym: "5-FU" RELATED [KEGG_COMPOUND] +synonym: "Fluorouracil" RELATED [KEGG_COMPOUND] +synonym: "fluorouracil" RELATED INN [WHO_MedNet] +synonym: "fluorouracil" RELATED INN [ChemIDplus] +synonym: "fluorouracilo" RELATED INN [ChemIDplus] +synonym: "fluorouracilum" RELATED INN [ChemIDplus] +xref: Beilstein:127172 {source="Beilstein"} +xref: CAS:51-21-8 {source="ChemIDplus"} +xref: CAS:51-21-8 {source="KEGG COMPOUND"} +xref: Drug_Central:26 {source="DrugCentral"} +xref: DrugBank:DB00544 +xref: HMDB:HMDB0014684 +xref: KEGG:C07649 +xref: KEGG:D00584 +xref: LINCS:LSM-4261 +xref: PDBeChem:URF +xref: PMID:11356943 {source="Europe PMC"} +xref: PMID:12520460 {source="Europe PMC"} +xref: PMID:14769231 {source="Europe PMC"} +xref: PMID:19023200 {source="Europe PMC"} +xref: Reaxys:127172 {source="Reaxys"} +xref: Wikipedia:Fluorouracil +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:67142 ! nucleobase analogue +relationship: has_functional_parent CHEBI:17568 ! uracil +relationship: has_role CHEBI:132992 ! radiosensitizing agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H3FN2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GHASVSINZRGABV-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "130.07730" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.01786" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1c[nH]c(=O)[nH]c1=O" xsd:string + +[Term] +id: CHEBI:4640 +name: diphenylamine +namespace: chebi_ontology +def: "An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union." [] +subset: 3_STAR +synonym: "(phenylamino)benzene" RELATED [NIST_Chemistry_WebBook] +synonym: "anilinobenzene" RELATED [NIST_Chemistry_WebBook] +synonym: "C6H5-NH-C6H5" RELATED [IUPAC] +synonym: "Diphenylamine" EXACT [KEGG_COMPOUND] +synonym: "DPA" RELATED [NIST_Chemistry_WebBook] +synonym: "N,N-diphenylamine" RELATED [ChemIDplus] +synonym: "N-phenylaniline" EXACT IUPAC_NAME [IUPAC] +synonym: "N-phenylbenzenamine" RELATED [ChemIDplus] +xref: Beilstein:508755 {source="Beilstein"} +xref: CAS:122-39-4 {source="ChemIDplus"} +xref: CAS:122-39-4 {source="NIST Chemistry WebBook"} +xref: CAS:122-39-4 {source="KEGG COMPOUND"} +xref: Gmelin:67833 {source="Gmelin"} +xref: HMDB:HMDB0032562 +xref: KEGG:C11016 +xref: MetaCyc:CPD-9937 +xref: Pesticides:diphenylamine {source="Alan Wood's Pesticides"} +xref: PMID:16172927 {source="Europe PMC"} +xref: PMID:16336182 {source="Europe PMC"} +xref: PMID:23200380 {source="Europe PMC"} +xref: PMID:23311914 {source="Europe PMC"} +xref: PMID:6446435 {source="Europe PMC"} +xref: PMID:8192920 {source="Europe PMC"} +xref: PPDB:1335 +xref: Reaxys:508755 {source="Reaxys"} +xref: Wikipedia:Diphenylamine +is_a: CHEBI:33860 ! aromatic amine +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:87039 ! bridged diphenyl fungicide +relationship: has_role CHEBI:173084 ! ferroptosis inhibitor +relationship: has_role CHEBI:48578 ! radical scavenger +relationship: has_role CHEBI:72773 ! carotogenesis inhibitor +relationship: has_role CHEBI:72774 ! EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor +relationship: has_role CHEBI:86328 ! antifungal agrochemical +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H11N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H11N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DMBHHRLKUKUOEG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "169.22248" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "169.08915" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N(c1ccccc1)c1ccccc1" xsd:string + [Term] id: CHEBI:46629 name: oxo group @@ -15398,6 +27048,43 @@ synonym: "mineraux" RELATED [ChEBI] xref: Wikipedia:Mineral is_a: CHEBI:59999 ! chemical substance +[Term] +id: CHEBI:46668 +name: amino acid ester +namespace: chebi_ontology +def: "Any carboxylic ester derivative of an amino acid." [] +subset: 3_STAR +synonym: "amino acid ester" EXACT [ChEBI] +synonym: "amino acid esters" RELATED [ChEBI] +is_a: CHEBI:33308 ! carboxylic ester +is_a: CHEBI:83821 ! amino acid derivative + +[Term] +id: CHEBI:46700 +name: benzoxazole +namespace: chebi_ontology +def: "Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton." [] +subset: 3_STAR +synonym: "benzoxazoles" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38104 ! oxacycle + +[Term] +id: CHEBI:46723 +name: phosphate mineral +synonym: "phosphate minerals" RELATED [] +is_a: CHEBI:46662 ! mineral + +[Term] +id: CHEBI:46775 +name: N-alkylpyrrolidine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-alkylpyrrolidines" RELATED [ChEBI] +is_a: CHEBI:38260 ! pyrrolidines +is_a: CHEBI:50996 ! tertiary amino compound + [Term] id: CHEBI:46787 name: solvent @@ -15422,6 +27109,42 @@ is_a: CHEBI:25696 ! organic anion relationship: has_role CHEBI:77746 ! human metabolite relationship: is_conjugate_base_of CHEBI:27226 ! uric acid +[Term] +id: CHEBI:46845 +name: N-alkylpiperazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-alkylpiperazines" RELATED [ChEBI] +is_a: CHEBI:26144 ! piperazines +is_a: CHEBI:50996 ! tertiary amino compound + +[Term] +id: CHEBI:46847 +name: N-iminopiperazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-iminopiperazines" RELATED [ChEBI] +is_a: CHEBI:26144 ! piperazines + +[Term] +id: CHEBI:46848 +name: N-arylpiperazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-arylpiperazines" RELATED [ChEBI] +is_a: CHEBI:26144 ! piperazines +is_a: CHEBI:33860 ! aromatic amine +is_a: CHEBI:50996 ! tertiary amino compound + +[Term] +id: CHEBI:46851 +name: N-(2-hydroxyethyl)piperazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-(2-hydroxyethyl)piperazines" RELATED [ChEBI] +is_a: CHEBI:23981 ! ethanolamines +is_a: CHEBI:46845 ! N-alkylpiperazine + [Term] id: CHEBI:46883 name: carboxy group @@ -15443,6 +27166,24 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(=O)O" xsd:string +[Term] +id: CHEBI:46920 +name: N-methylpiperazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-methylpiperazines" RELATED [ChEBI] +is_a: CHEBI:46845 ! N-alkylpiperazine + +[Term] +id: CHEBI:46952 +name: oxazinane +namespace: chebi_ontology +subset: 3_STAR +synonym: "oxazinanes" RELATED [ChEBI] +is_a: CHEBI:25693 ! organic heteromonocyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38104 ! oxacycle + [Term] id: CHEBI:46963 name: 2-aminooctadecene-1,3-diol @@ -15518,6 +27259,94 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "299.49190" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "299.28243" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCC\\C=C\\[C@H](O)[C@H](N)CO" xsd:string +[Term] +id: CHEBI:46969 +name: benzoxazine +namespace: chebi_ontology +subset: 3_STAR +synonym: "benzoxazines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38104 ! oxacycle + +[Term] +id: CHEBI:47017 +name: tetrahydrofuranol +namespace: chebi_ontology +subset: 3_STAR +synonym: "tetrahydrofuranols" RELATED [ChEBI] +is_a: CHEBI:26912 ! oxolanes + +[Term] +id: CHEBI:47018 +name: monohydroxytetrahydrofuran +namespace: chebi_ontology +subset: 3_STAR +synonym: "monohydroxytetrahydrofurans" RELATED [ChEBI] +is_a: CHEBI:47017 ! tetrahydrofuranol + +[Term] +id: CHEBI:47381 +name: diclofenac +namespace: chebi_ontology +alt_id: CHEBI:4507 +alt_id: CHEBI:47380 +def: "A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position." [] +subset: 3_STAR +synonym: "2-((2,6-dichlorophenyl)amino)benzeneacetic acid" RELATED [ChemIDplus] +synonym: "2-[(2,6-dichlorophenyl)amino]benzeneacetic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "[2-(2,6-dichloroanilino)phenyl]acetic acid" RELATED [NIST_Chemistry_WebBook] +synonym: "Diclofenac" EXACT [KEGG_COMPOUND] +synonym: "diclofenac" RELATED INN [ChemIDplus] +synonym: "diclofenac acid" RELATED [ChemIDplus] +synonym: "diclofenaco" RELATED INN [ChemIDplus] +synonym: "diclofenacum" RELATED INN [ChemIDplus] +synonym: "diclofenamic acid" RELATED [DrugCentral] +synonym: "{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:2146636 {source="Beilstein"} +xref: CAS:15307-86-5 {source="NIST Chemistry WebBook"} +xref: CAS:15307-86-5 {source="ChemIDplus"} +xref: CAS:15307-86-5 {source="KEGG COMPOUND"} +xref: Drug_Central:865 {source="DrugCentral"} +xref: DrugBank:DB00586 +xref: HMDB:HMDB0014724 +xref: KEGG:C01690 +xref: KEGG:D07816 +xref: LINCS:LSM-2160 +xref: Patent:NL6604752 +xref: Patent:US3558690 +xref: PDBeChem:DIF +xref: PMID:11322639 {source="Europe PMC"} +xref: PMID:1502708 {source="Europe PMC"} +xref: PMID:23777257 {source="Europe PMC"} +xref: PMID:27967303 {source="Europe PMC"} +xref: PMID:7838674 {source="Europe PMC"} +xref: Reaxys:2146636 {source="Reaxys"} +xref: VSDB:1933 +xref: Wikipedia:Diclofenac +is_a: CHEBI:23697 ! dichlorobenzene +is_a: CHEBI:25384 ! monocarboxylic acid +is_a: CHEBI:33709 ! amino acid +is_a: CHEBI:33860 ! aromatic amine +is_a: CHEBI:50995 ! secondary amino compound +relationship: has_functional_parent CHEBI:30745 ! phenylacetic acid +relationship: has_functional_parent CHEBI:4640 ! diphenylamine +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35493 ! antipyretic +relationship: has_role CHEBI:35544 ! EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: has_role CHEBI:88188 ! drug allergen +relationship: is_conjugate_acid_of CHEBI:48311 ! diclofenac(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H11Cl2NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DCOPUUMXTXDBNB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "296.150" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "295.01668" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl" xsd:string + [Term] id: CHEBI:47622 name: acetate ester @@ -15545,6 +27374,37 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "59.04400" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01330" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)O[*]" xsd:string +[Term] +id: CHEBI:47724 +name: vancomycin aglycone +namespace: chebi_ontology +def: "A peptide antibiotic that is vancomycin lacking the disaccharide moiety." [] +subset: 3_STAR +synonym: "(1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37,48-hexahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "Aglucovancomycin B" RELATED [ChemIDplus] +synonym: "Balhimycin aglycon" RELATED [ChemIDplus] +xref: CAS:82198-76-3 {source="ChemIDplus"} +xref: MetaCyc:CPD-15745 +xref: PMID:11470430 {source="Europe PMC"} +xref: PMID:14649827 {source="Europe PMC"} +xref: PMID:15785812 {source="Europe PMC"} +xref: PMID:22177724 {source="Europe PMC"} +xref: Reaxys:6049255 {source="Reaxys"} +is_a: CHEBI:24533 ! heterodetic cyclic peptide +is_a: CHEBI:25903 ! peptide antibiotic +is_a: CHEBI:26195 ! polyphenol +is_a: CHEBI:37407 ! cyclic ether +relationship: has_role CHEBI:25212 ! metabolite +relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) +relationship: is_tautomer_of CHEBI:75954 ! vancomycin aglycone zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H52Cl2N8O17" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1143.92900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1142.28275" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C(O)=O)c3O)c(Cl)c2" xsd:string + [Term] id: CHEBI:47773 name: very-low-density lipoprotein cholesterol @@ -15593,6 +27453,14 @@ synonym: "glycerides" RELATED [ChEBI] is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:35741 ! glycerolipid +[Term] +id: CHEBI:47779 +name: aminoglycoside +namespace: chebi_ontology +subset: 3_STAR +synonym: "aminoglycosides" RELATED [ChEBI] +is_a: CHEBI:24400 ! glycoside + [Term] id: CHEBI:47788 name: 3-oxo steroid @@ -15618,6 +27486,46 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "273.434" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.22184" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCC(C4)=O)C" xsd:string +[Term] +id: CHEBI:47804 +name: dibenzoazepine +namespace: chebi_ontology +subset: 3_STAR +synonym: "dibenzazepine" RELATED [ChEBI] +synonym: "dibenzoazepine" EXACT [ChEBI] +synonym: "dibenzoazepines" RELATED [ChEBI] +is_a: CHEBI:26979 ! organic heterotricyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:47857 +name: ureas +namespace: chebi_ontology +alt_id: CHEBI:27220 +alt_id: CHEBI:36947 +subset: 3_STAR +synonym: "urea derivatives" RELATED [ChEBI] +is_a: CHEBI:33256 ! primary amide +relationship: has_functional_parent CHEBI:16199 ! urea + +[Term] +id: CHEBI:47867 +name: indicator +namespace: chebi_ontology +def: "Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc." [] +subset: 3_STAR +synonym: "Indikator" RELATED [ChEBI] +is_a: CHEBI:33232 ! application + +[Term] +id: CHEBI:47868 +name: photosensitizing agent +namespace: chebi_ontology +def: "A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells." [] +subset: 3_STAR +synonym: "photosensitising agent" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:47882 name: cyclic polypyrrole @@ -15628,6 +27536,17 @@ synonym: "macrocyclic polypyrroles" EXACT IUPAC_NAME [IUPAC] synonym: "polypyrrole macrocycles" RELATED [ChEBI] is_a: CHEBI:38077 ! polypyrrole +[Term] +id: CHEBI:47891 +name: steroid acid +namespace: chebi_ontology +def: "Any steroid substituted by at least one carboxy group." [] +subset: 3_STAR +synonym: "steroid acids" RELATED [ChEBI] +is_a: CHEBI:35341 ! steroid +is_a: CHEBI:64709 ! organic acid +relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion + [Term] id: CHEBI:47909 name: 3-oxo-Delta(4) steroid @@ -15673,6 +27592,59 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "186.146" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "186.05148" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)(NC(C(NC(C(=O)O)*)=O)*)C(N)*" xsd:string +[Term] +id: CHEBI:47958 +name: nicotinic acetylcholine receptor agonist +namespace: chebi_ontology +alt_id: CHEBI:82738 +def: "An agonist that selectively binds to and activates a nicotinic acetylcholine receptor." [] +subset: 3_STAR +synonym: "muscarinic agonists" RELATED [ChEBI] +synonym: "nicotinic acetylcholine receptor agonists" RELATED [ChEBI] +synonym: "nicotinic agonist" RELATED [ChEBI] +synonym: "nicotinic agonists" RELATED [ChEBI] +xref: Wikipedia:Nicotinic_acetylcholine_receptor +is_a: CHEBI:38324 ! cholinergic agonist + +[Term] +id: CHEBI:47985 +name: enol ether +namespace: chebi_ontology +def: "Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage." [] +subset: 3_STAR +synonym: "enol ether" EXACT [ChEBI] +synonym: "enol ethers" RELATED [ChEBI] +is_a: CHEBI:25698 ! ether +is_a: CHEBI:78840 ! olefinic compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2OR4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "40.02080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "39.99491" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])O[*]" xsd:string + +[Term] +id: CHEBI:48001 +name: protein synthesis inhibitor +namespace: chebi_ontology +def: "A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein." [] +subset: 3_STAR +synonym: "protein synthesis antagonist" RELATED [ChEBI] +synonym: "protein synthesis antagonists" RELATED [ChEBI] +synonym: "protein synthesis inhibitors" RELATED [ChEBI] +is_a: CHEBI:76932 ! pathway inhibitor + +[Term] +id: CHEBI:48120 +name: anthracycline +namespace: chebi_ontology +def: "Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine." [] +subset: 3_STAR +synonym: "anthracycline" EXACT [ChEBI] +synonym: "anthracyclines" RELATED [ChEBI] +is_a: CHEBI:26188 ! polyketide +relationship: has_role CHEBI:25212 ! metabolite +relationship: is_conjugate_base_of CHEBI:64678 ! anthracycline cation + [Term] id: CHEBI:48154 name: sulfur oxide @@ -15723,6 +27695,37 @@ synonym: "serotonergic drugs" RELATED [ChEBI] synonym: "serotonin drugs" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent +[Term] +id: CHEBI:48279 +name: serotonergic antagonist +namespace: chebi_ontology +def: "Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists." [] +subset: 3_STAR +synonym: "5-HT antagonists" RELATED [ChEBI] +synonym: "5-hydroxytryptamine antagonists" RELATED [ChEBI] +synonym: "antiserotonergic agents" RELATED [ChEBI] +synonym: "serotonin antagonists" RELATED [ChEBI] +synonym: "serotonin blockaders" RELATED [ChEBI] +is_a: CHEBI:48278 ! serotonergic drug + +[Term] +id: CHEBI:48311 +name: diclofenac(1-) +namespace: chebi_ontology +def: "The conjugate base of diclofenac." [] +subset: 3_STAR +synonym: "{2-[(2,6-dichlorophenyl)amino]phenyl}acetate" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:3560933 {source="Beilstein"} +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:47381 ! diclofenac +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H10Cl2NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DCOPUUMXTXDBNB-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "295.14014" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "294.00941" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl" xsd:string + [Term] id: CHEBI:48354 name: polar solvent @@ -15835,6 +27838,29 @@ synonym: "isoureas" EXACT IUPAC_NAME [IUPAC] synonym: "isoureas" RELATED [ChEBI] is_a: CHEBI:48378 ! carboximidic acid +[Term] +id: CHEBI:48420 +name: biphenylyltetrazole +namespace: chebi_ontology +def: "A member of the class of biphenyls that consists of a biphenyl ring system substituted by a tetrazole ring at an unspecified position." [] +subset: 3_STAR +synonym: "biphenylyltetrazoles" RELATED [ChEBI] +is_a: CHEBI:22888 ! biphenyls +is_a: CHEBI:35689 ! tetrazoles + +[Term] +id: CHEBI:48422 +name: angiogenesis inhibitor +namespace: chebi_ontology +alt_id: CHEBI:67170 +def: "An agent and endogenous substances that antagonize or inhibit the development of new blood vessels." [] +subset: 3_STAR +synonym: "angiogenesis antagonist" RELATED [ChEBI] +synonym: "angiostatic agents" RELATED [ChEBI] +synonym: "anti-angiogenic agent" RELATED [ChEBI] +xref: Wikipedia:Angiogenesis_inhibitor +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:48539 name: alpha-adrenergic drug @@ -15866,6 +27892,83 @@ synonym: "dopamine drugs" RELATED [ChEBI] synonym: "dopaminergic agents" RELATED [ChEBI] is_a: CHEBI:35942 ! neurotransmitter agent +[Term] +id: CHEBI:48561 +name: dopaminergic antagonist +namespace: chebi_ontology +def: "A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists." [] +subset: 3_STAR +synonym: "dopamine antagonist" RELATED [ChEBI] +synonym: "dopamine blocker" RELATED [ChEBI] +synonym: "dopamine receptor antagonist" RELATED [ChEBI] +synonym: "dopaminergic antagonists" RELATED [ChEBI] +is_a: CHEBI:48560 ! dopaminergic agent + +[Term] +id: CHEBI:48578 +name: radical scavenger +namespace: chebi_ontology +def: "A role played by a substance that can react readily with, and thereby eliminate, radicals." [] +subset: 3_STAR +synonym: "free radical scavengers" RELATED [ChEBI] +synonym: "free-radical scavenger" RELATED [ChEBI] +is_a: CHEBI:22586 ! antioxidant + +[Term] +id: CHEBI:48585 +name: heteroarylpiperidine +namespace: chebi_ontology +subset: 3_STAR +synonym: "heteroarylpiperidines" RELATED [ChEBI] +is_a: CHEBI:26151 ! piperidines + +[Term] +id: CHEBI:48589 +name: piperidones +namespace: chebi_ontology +subset: 3_STAR +synonym: "piperidone" RELATED [ChEBI] +is_a: CHEBI:26151 ! piperidines +is_a: CHEBI:36963 ! organooxygen compound + +[Term] +id: CHEBI:48590 +name: hydroxypiperidine +namespace: chebi_ontology +subset: 3_STAR +synonym: "hydroxypiperidines" RELATED [ChEBI] +is_a: CHEBI:26151 ! piperidines + +[Term] +id: CHEBI:48591 +name: N-acylpiperidine +namespace: chebi_ontology +subset: 3_STAR +synonym: "N-acylpiperidines" RELATED [ChEBI] +is_a: CHEBI:26151 ! piperidines +is_a: CHEBI:32988 ! amide + +[Term] +id: CHEBI:48626 +name: pyranoindolizinoquinoline +namespace: chebi_ontology +subset: 3_STAR +synonym: "pyranoindolizinoquinolines" RELATED [ChEBI] +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38104 ! oxacycle +is_a: CHEBI:38164 ! organic heteropentacyclic compound + +[Term] +id: CHEBI:48676 +name: fibrin modulating drug +namespace: chebi_ontology +def: "A drug that affects the function of fibrin in blood coagulation." [] +subset: 3_STAR +synonym: "fibrin modulating agent" RELATED [ChEBI] +synonym: "fibrin modulating agents" RELATED [ChEBI] +synonym: "fibrin modulating drugs" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:48705 name: agonist @@ -15890,6 +27993,66 @@ synonym: "antagoniste" RELATED [ChEBI] synonym: "antagonists" RELATED [ChEBI] is_a: CHEBI:52210 ! pharmacological role +[Term] +id: CHEBI:48819 +name: cyano group +namespace: chebi_ontology +alt_id: CHEBI:36824 +alt_id: CHEBI:48818 +subset: 3_STAR +synonym: "-C#N" RELATED [IUPAC] +synonym: "-CN" RELATED [IUPAC] +synonym: "carbonitrile group" RELATED [ChEBI] +synonym: "CYANIDE GROUP" RELATED [PDBeChem] +synonym: "cyanido" EXACT IUPAC_NAME [IUPAC] +synonym: "cyano" EXACT IUPAC_NAME [IUPAC] +synonym: "NC-" RELATED [IUPAC] +xref: PDBeChem:CYN +is_a: CHEBI:36823 ! pseudohalo group +relationship: is_substituent_group_from CHEBI:18407 ! hydrogen cyanide +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CN" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "26.017" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "26.00307" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(#N)*" xsd:string + +[Term] +id: CHEBI:48854 +name: sulfurous acid +namespace: chebi_ontology +alt_id: CHEBI:26837 +alt_id: CHEBI:9344 +subset: 3_STAR +synonym: "[SO(OH)2]" RELATED [IUPAC] +synonym: "acide sulfureux" RELATED [ChEBI] +synonym: "acido sulfuroso" RELATED [ChEBI] +synonym: "dihydrogen trioxosulfate" EXACT IUPAC_NAME [IUPAC] +synonym: "dihydroxidooxidosulfur" EXACT IUPAC_NAME [IUPAC] +synonym: "H2SO3" RELATED [IUPAC] +synonym: "S(O)(OH)2" RELATED [IUPAC] +synonym: "schweflige Saeure" RELATED [ChemIDplus] +synonym: "Sulfite" RELATED [KEGG_COMPOUND] +synonym: "Sulfurous acid" EXACT [KEGG_COMPOUND] +synonym: "sulfurous acid" EXACT IUPAC_NAME [IUPAC] +synonym: "sulphurous acid" RELATED [ChemIDplus] +synonym: "trioxosulfuric acid" EXACT IUPAC_NAME [IUPAC] +xref: CAS:7782-99-2 {source="ChemIDplus"} +xref: Gmelin:1458 {source="Gmelin"} +xref: KEGG:C00094 +xref: KNApSAcK:C00019662 +xref: PDBeChem:SO3 +xref: UM-BBD_compID:c0348 {source="UM-BBD"} +is_a: CHEBI:33402 ! sulfur oxoacid +relationship: is_conjugate_acid_of CHEBI:17137 ! hydrogensulfite +relationship: is_tautomer_of CHEBI:29214 ! sulfonic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LSNNMFCWUKXFEE-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "82.08008" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "81.97247" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OS(O)=O" xsd:string + [Term] id: CHEBI:48873 name: cholinergic antagonist @@ -15910,6 +28073,23 @@ synonym: "anticolinergicos" RELATED [ChEBI] synonym: "cholinergic-blocking agents" RELATED [ChEBI] is_a: CHEBI:38323 ! cholinergic drug +[Term] +id: CHEBI:48876 +name: muscarinic antagonist +namespace: chebi_ontology +def: "A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists." [] +subset: 3_STAR +synonym: "agente antimuscarinico" RELATED [ChEBI] +synonym: "agentes antimuscarinicos" RELATED [ChEBI] +synonym: "agents antimuscariniques" RELATED [ChEBI] +synonym: "antimuscarinic agents" RELATED [ChEBI] +synonym: "antimuscarinicos" RELATED [ChEBI] +synonym: "Antimuskarinika" RELATED [ChEBI] +synonym: "Antimuskarinikum" RELATED [ChEBI] +synonym: "muscarinic acetylcholine receptor antagonist" RELATED [ChEBI] +synonym: "muscarinic antagonists" RELATED [ChEBI] +is_a: CHEBI:48873 ! cholinergic antagonist + [Term] id: CHEBI:48901 name: thiazoles @@ -15938,6 +28118,153 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H3NO3R2" xsd:str property_value: http://purl.obolibrary.org/obo/chebi/mass "101.061" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.01129" xsd:string +[Term] +id: CHEBI:48946 +name: 2-methylbutyrate +namespace: chebi_ontology +subset: 3_STAR +synonym: "2-methylbutanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "2-methylbutanoate" RELATED [UniProt] +xref: Beilstein:4127269 {source="Beilstein"} +is_a: CHEBI:58951 ! short-chain fatty acid anion +is_a: CHEBI:58956 ! branched-chain saturated fatty acid anion +relationship: is_conjugate_base_of CHEBI:37070 ! 2-methylbutyric acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H9O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H10O2/c1-3-4(2)5(6)7/h4H,3H2,1-2H3,(H,6,7)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WLAMNBDJUVNPJU-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "101.12376" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "101.06080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)C([O-])=O" xsd:string + +[Term] +id: CHEBI:48975 +name: substituted aniline +namespace: chebi_ontology +subset: 3_STAR +synonym: "substituted anilines" RELATED [ChEBI] +is_a: CHEBI:22562 ! anilines + +[Term] +id: CHEBI:49020 +name: hormone antagonist +namespace: chebi_ontology +def: "A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites." [] +subset: 3_STAR +synonym: "hormone antagonists" RELATED [ChEBI] +is_a: CHEBI:48706 ! antagonist +is_a: CHEBI:51061 ! hormone receptor modulator + +[Term] +id: CHEBI:49023 +name: prostaglandin antagonist +namespace: chebi_ontology +def: "A compound that inhibits the action of prostaglandins." [] +subset: 3_STAR +synonym: "prostaglandin inhibitor" RELATED [ChEBI] +xref: Wikipedia:Prostaglandin_antagonist +is_a: CHEBI:49020 ! hormone antagonist + +[Term] +id: CHEBI:49095 +name: beta-amino-acid anion +namespace: chebi_ontology +subset: 1_STAR +is_a: CHEBI:37022 ! amino-acid anion + +[Term] +id: CHEBI:49103 +name: drug metabolite +namespace: chebi_ontology +subset: 3_STAR +synonym: "drug metabolites" RELATED [ChEBI] +is_a: CHEBI:76967 ! human xenobiotic metabolite + +[Term] +id: CHEBI:4911 +name: etoposide +namespace: chebi_ontology +subset: 3_STAR +synonym: "(-)-etoposide" RELATED [DrugBank] +synonym: "(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC] +synonym: "4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)" RELATED [ChemIDplus] +synonym: "4-demethylepipodophyllotoxin beta-D-ethylideneglucoside" RELATED [ChemIDplus] +synonym: "9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one" RELATED [ChemIDplus] +synonym: "Eposin" RELATED BRAND_NAME [DrugBank] +synonym: "Etopophos" RELATED BRAND_NAME [DrugBank] +synonym: "Etoposide" EXACT [KEGG_COMPOUND] +synonym: "etoposide" RELATED INN [ChemIDplus] +synonym: "Etoposido" RELATED INN [ChemIDplus] +synonym: "etoposidum" RELATED INN [ChemIDplus] +synonym: "Lastet" RELATED BRAND_NAME [DrugBank] +synonym: "Toposar" RELATED BRAND_NAME [DrugBank] +synonym: "trans-Etoposide" RELATED [DrugBank] +synonym: "Vepesid" RELATED BRAND_NAME [DrugBank] +synonym: "VP-16" RELATED [KEGG_COMPOUND] +xref: CAS:33419-42-0 {source="KEGG COMPOUND"} +xref: CAS:33419-42-0 {source="ChemIDplus"} +xref: Drug_Central:1112 {source="DrugCentral"} +xref: DrugBank:DB00773 +xref: KEGG:C01576 +xref: KEGG:D00125 +xref: LINCS:LSM-6348 +xref: Patent:US3524844 +xref: Wikipedia:Etoposide +is_a: CHEBI:22798 ! beta-D-glucoside +is_a: CHEBI:50307 ! furonaphthodioxole +relationship: has_functional_parent CHEBI:50305 ! podophyllotoxin +relationship: has_functional_parent CHEBI:74422 ! 4'-demethylepipodophyllotoxin +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:59517 ! DNA synthesis inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C29H32O13" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "VJJPUSNTGOMMGY-MRVIYFEKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "588.55660" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "588.18429" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@@H]2CO[C@@H](C)O[C@H]2[C@H](O)[C@H]1O" xsd:string + +[Term] +id: CHEBI:49110 +name: peripheral nervous system drug +namespace: chebi_ontology +def: "A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system." [] +subset: 3_STAR +synonym: "peripheral nervous system agent" RELATED [ChEBI] +synonym: "peripheral nervous system drugs" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:49159 +name: leukotriene antagonist +namespace: chebi_ontology +def: "A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level." [] +subset: 3_STAR +synonym: "leukotriene antagonists" RELATED [ChEBI] +synonym: "leukotriene receptor antagonist" RELATED [ChEBI] +synonym: "leukotriene receptor antagonists" RELATED [ChEBI] +synonym: "LTRA" RELATED [DrugBank] +is_a: CHEBI:49020 ! hormone antagonist + +[Term] +id: CHEBI:49165 +name: montelukast(1-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetate" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:7612011 {source="Beilstein"} +is_a: CHEBI:22327 ! aliphatic sulfide +is_a: CHEBI:26513 ! quinolines +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:50730 ! montelukast +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C35H35ClNO3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/p-1/b15-10+/t32-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCHDWCPVSPXUMX-TZIWLTJVSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "585.17604" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "584.20317" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC1)CC([O-])=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1" xsd:string + [Term] id: CHEBI:49167 name: anti-asthmatic drug @@ -15950,6 +28277,32 @@ synonym: "anti-asthmatic drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:65023 ! anti-asthmatic agent +[Term] +id: CHEBI:49200 +name: EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor +namespace: chebi_ontology +def: "An EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that inhibits H(+)/K(+)-exchanging ATPase, EC 3.6.3.10. Such compounds are also known as proton pump inhibitors." [] +subset: 3_STAR +synonym: "(K(+) + H(+))-ATPase inhibitor" RELATED [ChEBI] +synonym: "(K(+) + H(+))-ATPase inhibitors" RELATED [ChEBI] +synonym: "ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitor" RELATED [ChEBI] +synonym: "ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.3.10 inhibitor" RELATED [ChEBI] +synonym: "EC 3.6.3.10 inhibitors" RELATED [ChEBI] +synonym: "H(+)-K(+)-ATPase inhibitor" RELATED [ChEBI] +synonym: "H(+)-K(+)-ATPase inhibitors" RELATED [ChEBI] +synonym: "H(+)/K(+)-ATPase inhibitor" RELATED [ChEBI] +synonym: "H(+)/K(+)-ATPase inhibitors" RELATED [ChEBI] +synonym: "H(+)/K(+)-exchanging ATPase inhibitor" RELATED [ChEBI] +synonym: "H(+)/K(+)-exchanging ATPase inhibitors" RELATED [ChEBI] +synonym: "H,K-ATPase inhibitor" RELATED [ChEBI] +synonym: "H,K-ATPase inhibitors" RELATED [ChEBI] +synonym: "proton pump inhibitor" RELATED [ChEBI] +synonym: "proton pump inhibitors" RELATED [ChEBI] +xref: Wikipedia:Proton_pump_inhibitor +is_a: CHEBI:76895 ! EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor + [Term] id: CHEBI:49302 name: 2-hydroxy monocarboxylic acid @@ -15961,6 +28314,19 @@ synonym: "2-hydroxy acid" RELATED [ChEBI] synonym: "2-hydroxy monocarboxylic acids" RELATED [ChEBI] is_a: CHEBI:35868 ! hydroxy monocarboxylic acid +[Term] +id: CHEBI:49322 +name: anthracycline antibiotic +namespace: chebi_ontology +alt_id: CHEBI:22573 +alt_id: CHEBI:22574 +def: "An organic compound that has a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine and which exhibits antibiotic activity." [] +subset: 3_STAR +synonym: "anthracycline antibiotics" RELATED [ChEBI] +synonym: "anthracyclines" RELATED [ChEBI] +is_a: CHEBI:48120 ! anthracycline +relationship: has_role CHEBI:33281 ! antimicrobial agent + [Term] id: CHEBI:49323 name: contraceptive drug @@ -15971,6 +28337,40 @@ synonym: "contraceptive agent" RELATED [ChEBI] synonym: "contraceptive drugs" RELATED [ChEBI] is_a: CHEBI:50689 ! reproductive control drug +[Term] +id: CHEBI:49603 +name: lapatinib +namespace: chebi_ontology +alt_id: CHEBI:38636 +alt_id: CHEBI:49602 +subset: 3_STAR +synonym: "GW 572016" RELATED [ChemIDplus] +synonym: "N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine" RELATED [ChemIDplus] +synonym: "N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE" RELATED [PDBeChem] +synonym: "Tykerb" RELATED [ChemIDplus] +xref: Beilstein:10502247 {source="Beilstein"} +xref: CAS:231277-92-2 {source="ChemIDplus"} +xref: Drug_Central:1548 {source="DrugCentral"} +xref: DrugBank:DB01259 +xref: LINCS:LSM-1051 +xref: PDBeChem:FMM +xref: Wikipedia:Lapatinib +is_a: CHEBI:24129 ! furans +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:38530 ! quinazolines +relationship: has_functional_parent CHEBI:5115 ! monofluorobenzene +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:38637 ! tyrosine kinase inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C29H26ClFN4O4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BCFGMOOMADDAQU-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "581.05840" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "580.13473" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1" xsd:string + [Term] id: CHEBI:49637 name: hydrogen atom @@ -15998,6 +28398,151 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]" xsd:string +[Term] +id: CHEBI:49668 +name: gefitinib +namespace: chebi_ontology +alt_id: CHEBI:38917 +alt_id: CHEBI:49667 +def: "A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer." [] +subset: 3_STAR +synonym: "4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline" RELATED [ChemIDplus] +synonym: "gefitinib" RELATED INN [WHO_MedNet] +synonym: "gefitinibum" RELATED INN [WHO_MedNet] +synonym: "Iressa" RELATED BRAND_NAME [ChemIDplus] +synonym: "Irressat" RELATED BRAND_NAME [ChemIDplus] +synonym: "N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine" RELATED [ChemIDplus] +synonym: "N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "ZD 1839" RELATED [ChemIDplus] +synonym: "ZD-1839" RELATED [DrugBank] +synonym: "ZD1839" RELATED [DrugCentral] +xref: CAS:184475-35-2 {source="ChemIDplus"} +xref: Drug_Central:1282 {source="DrugCentral"} +xref: DrugBank:DB00317 +xref: HMDB:HMDB0014462 +xref: KEGG:D01977 +xref: LINCS:LSM-1098 +xref: PDBeChem:IRE +xref: PMID:14981586 {source="Europe PMC"} +xref: PMID:15068398 {source="Europe PMC"} +xref: PMID:20573926 {source="Europe PMC"} +xref: PMID:20949670 {source="Europe PMC"} +xref: PMID:27396387 {source="Europe PMC"} +xref: PMID:28968167 {source="Europe PMC"} +xref: PMID:29332330 {source="Europe PMC"} +xref: PMID:29493460 {source="Europe PMC"} +xref: PMID:29579334 {source="Europe PMC"} +xref: PMID:29668619 {source="Europe PMC"} +xref: PMID:30068310 {source="Europe PMC"} +xref: PMID:30069771 {source="Europe PMC"} +xref: PMID:30214852 {source="Europe PMC"} +xref: Reaxys:8949523 {source="Reaxys"} +xref: Wikipedia:Gefitinib +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:38530 ! quinazolines +is_a: CHEBI:38785 ! morpholines +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:50996 ! tertiary amino compound +is_a: CHEBI:83403 ! monochlorobenzenes +is_a: CHEBI:83575 ! monofluorobenzenes +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:74440 ! epidermal growth factor receptor antagonist +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H24ClFN4O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XGALLCVXEZPNRQ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "446.910" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "446.15210" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C(=CC=2C1=NC=NC2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4)OC" xsd:string + +[Term] +id: CHEBI:49713 +name: lithium(1+) +namespace: chebi_ontology +alt_id: CHEBI:30143 +alt_id: CHEBI:49711 +subset: 3_STAR +synonym: "Li(+)" RELATED [UniProt] +synonym: "Li(+)" RELATED [IUPAC] +synonym: "lithium cation" RELATED [NIST_Chemistry_WebBook] +synonym: "LITHIUM ION" RELATED [PDBeChem] +synonym: "lithium(1+)" EXACT IUPAC_NAME [IUPAC] +synonym: "lithium(1+) ion" EXACT IUPAC_NAME [IUPAC] +synonym: "lithium(I) cation" EXACT IUPAC_NAME [IUPAC] +synonym: "lithium, ion" RELATED [NIST_Chemistry_WebBook] +synonym: "Lithium, ion (Li1+)" RELATED [ChemIDplus] +xref: CAS:17341-24-1 {source="NIST Chemistry WebBook"} +xref: CAS:17341-24-1 {source="ChemIDplus"} +xref: DrugBank:DB01356 +xref: Gmelin:15205 {source="Gmelin"} +xref: PDBeChem:LI +is_a: CHEBI:25414 ! monoatomic monocation +is_a: CHEBI:33504 ! alkali metal cation +is_a: CHEBI:60242 ! monovalent inorganic cation +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "Li" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Li/q+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HBBGRARXTFLTSG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "6.94100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "7.01545" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Li+]" xsd:string + +[Term] +id: CHEBI:5001 +name: fenofibrate +namespace: chebi_ontology +def: "A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring." [] +subset: 3_STAR +synonym: "2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester" RELATED [ChemIDplus] +synonym: "Antara" RELATED BRAND_NAME [DrugBank] +synonym: "Fenofibrate" EXACT [KEGG_COMPOUND] +synonym: "Finofibrate" RELATED [DrugBank] +synonym: "FNF" RELATED [DrugBank] +synonym: "Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate" RELATED [ChemIDplus] +synonym: "Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate" RELATED [ChemIDplus] +synonym: "Lipantil" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Lipofen" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Procetofen" RELATED [ChemIDplus] +synonym: "propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "Tricor" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Triglide" RELATED BRAND_NAME [KEGG_DRUG] +xref: CAS:49562-28-9 {source="ChemIDplus"} +xref: CAS:49562-28-9 {source="NIST Chemistry WebBook"} +xref: Chemspider:3222 +xref: Drug_Central:1152 {source="DrugCentral"} +xref: DrugBank:DB01039 +xref: HMDB:HMDB0015173 +xref: KEGG:C07586 +xref: KEGG:D00565 +xref: LINCS:LSM-3107 +xref: Patent:DE2250327 +xref: Patent:US4058552 +xref: PMID:17449930 {source="Europe PMC"} +xref: PMID:18212815 {source="Europe PMC"} +xref: PMID:23603800 {source="Europe PMC"} +xref: PMID:32675219 {source="Europe PMC"} +xref: PMID:33704429 {source="Europe PMC"} +xref: PMID:34244236 {source="Europe PMC"} +xref: PMID:34515330 {source="Europe PMC"} +xref: Reaxys:2062462 {source="Reaxys"} +xref: Wikipedia:Fenofibrate +is_a: CHEBI:23135 ! chlorobenzophenone +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:35725 ! isopropyl ester +is_a: CHEBI:83403 ! monochlorobenzenes +relationship: has_functional_parent CHEBI:41308 ! benzophenone +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35679 ! antilipemic drug +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21ClO4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YMTINGFKWWXKFG-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "360.83100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.11284" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c1ccc(Cl)cc1" xsd:string + [Term] id: CHEBI:50047 name: organic amino compound @@ -16009,6 +28554,21 @@ is_a: CHEBI:35352 ! organonitrogen compound relationship: has_parent_hydride CHEBI:16134 ! ammonia relationship: has_role CHEBI:39142 ! Bronsted base +[Term] +id: CHEBI:50092 +name: 1H-pyrazolo[4,3-d]pyrimidine +namespace: chebi_ontology +subset: 3_STAR +xref: Beilstein:3198 {source="Beilstein"} +is_a: CHEBI:35570 ! mancude organic heterobicyclic parent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4/c1-5-4(2-8-9-5)7-3-6-1/h1-3H,(H,8,9)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "APXRHPDHORGIEB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "120.11222" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "120.04360" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1ncc2[nH]ncc2n1" xsd:string + [Term] id: CHEBI:50103 name: excitatory amino acid agonist @@ -16072,6 +28632,68 @@ synonym: "oestrogens" RELATED [ChEBI] xref: Wikipedia:Estrogen is_a: CHEBI:50112 ! sex hormone +[Term] +id: CHEBI:50127 +name: trifluoromethyl group +namespace: chebi_ontology +subset: 3_STAR +synonym: "-CF3" RELATED [IUPAC] +synonym: "trifluoromethyl" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:50491 ! haloalkyl group +relationship: is_substituent_group_from CHEBI:38825 ! tetrafluoromethane +relationship: is_substituent_group_from CHEBI:41550 ! fluoroform +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CF3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "69.00591" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "68.99521" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(F)(*)(F)F" xsd:string + +[Term] +id: CHEBI:50160 +name: steroid acid anion +namespace: chebi_ontology +def: "Any anion formed by loss of a proton from a steroid acid." [] +subset: 3_STAR +synonym: "steroid acid anions" RELATED [ChEBI] +is_a: CHEBI:29067 ! carboxylic acid anion +relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid + +[Term] +id: CHEBI:50176 +name: keratolytic drug +namespace: chebi_ontology +def: "A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases." [] +subset: 3_STAR +synonym: "desquamating agent" RELATED [ChEBI] +synonym: "keratolytic agent" RELATED [ChEBI] +synonym: "keratolytic drugs" RELATED [ChEBI] +synonym: "skin-peeling agent" RELATED [ChEBI] +is_a: CHEBI:50177 ! dermatologic drug + +[Term] +id: CHEBI:50177 +name: dermatologic drug +namespace: chebi_ontology +def: "A drug used to treat or prevent skin disorders or for the routine care of skin." [] +subset: 3_STAR +synonym: "dermatologic agent" RELATED [ChEBI] +synonym: "dermatologic drugs" RELATED [ChEBI] +synonym: "dermatological agent" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:50183 +name: P450 inhibitor +namespace: chebi_ontology +def: "An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances." [] +subset: 3_STAR +synonym: "CYP2D6 inhibitor" RELATED [ChEBI] +synonym: "CYP2D6 inhibitors" RELATED [ChEBI] +synonym: "cytochrome P450 inhibitor" RELATED [ChEBI] +synonym: "cytochrome P450 inhibitors" RELATED [ChEBI] +synonym: "P450 inhibitors" RELATED [ChEBI] +is_a: CHEBI:76898 ! EC 1.14.14.1 (unspecific monooxygenase) inhibitor + [Term] id: CHEBI:50188 name: provitamin @@ -16105,6 +28727,78 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "286.45160" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "286.22967" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C=CC=C(C)C=CC1=C(C)CCCC1(C)C)=CCO" xsd:string +[Term] +id: CHEBI:50248 +name: hematologic agent +namespace: chebi_ontology +def: "Drug that acts on blood and blood-forming organs and those that affect the hemostatic system." [] +subset: 3_STAR +synonym: "hematologic agents" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:50249 +name: anticoagulant +namespace: chebi_ontology +def: "An agent that prevents blood clotting." [] +subset: 3_STAR +synonym: "anticoagulante" RELATED [ChEBI] +synonym: "anticoagulants" RELATED [ChEBI] +is_a: CHEBI:50248 ! hematologic agent + +[Term] +id: CHEBI:50264 +name: thiazide +namespace: chebi_ontology +def: "Heterocyclic compound with sulfur and nitrogen in the ring." [] +subset: 3_STAR +synonym: "Thiazides" RELATED [ChEBI] +synonym: "tiazidas" RELATED [ChEBI] +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound +is_a: CHEBI:38106 ! organosulfur heterocyclic compound + +[Term] +id: CHEBI:50265 +name: benzothiadiazine +namespace: chebi_ontology +def: "Heterocyclic compound of a ring with sulfur and two nitrogen atoms fused to a benzene ring. Members inhibit sodium-potassium-chloride symporters and are used as diuretics." [] +subset: 3_STAR +synonym: "Benzothiadiazines" RELATED [ChEBI] +synonym: "benzothiadiazines" RELATED [ChEBI] +is_a: CHEBI:50264 ! thiazide + +[Term] +id: CHEBI:50266 +name: prodrug +namespace: chebi_ontology +def: "A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug." [] +subset: 3_STAR +synonym: "Prodrugs" RELATED [ChEBI] +xref: PMID:23993918 {source="Europe PMC"} +xref: PMID:23998799 {source="Europe PMC"} +xref: PMID:24329110 {source="Europe PMC"} +xref: PMID:24628402 {source="Europe PMC"} +xref: PMID:24709544 {source="Europe PMC"} +xref: PMID:25144792 {source="Europe PMC"} +xref: PMID:25157234 {source="Europe PMC"} +xref: PMID:25269430 {source="Europe PMC"} +xref: PMID:25391982 {source="Europe PMC"} +xref: PMID:25591121 {source="Europe PMC"} +xref: PMID:25620096 {source="Europe PMC"} +xref: PMID:25795057 {source="Europe PMC"} +xref: PMID:26028253 {source="Europe PMC"} +xref: PMID:26184144 {source="Europe PMC"} +xref: PMID:28070577 {source="Europe PMC"} +xref: PMID:28215138 {source="Europe PMC"} +xref: PMID:28219047 {source="Europe PMC"} +xref: PMID:28259775 {source="Europe PMC"} +xref: PMID:28319647 {source="Europe PMC"} +xref: PMID:28329729 {source="Europe PMC"} +xref: PMID:28334528 {source="Europe PMC"} +xref: Wikipedia:Prodrug +is_a: CHEBI:136859 ! pro-agent +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:50267 name: protective agent @@ -16118,6 +28812,37 @@ synonym: "chemoprotective agents" RELATED [ChEBI] synonym: "protective agents" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:50268 +name: GABA modulator +namespace: chebi_ontology +def: "A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act." [] +subset: 3_STAR +synonym: "GABA modulators" RELATED [ChEBI] +is_a: CHEBI:38632 ! membrane transport modulator +is_a: CHEBI:51374 ! GABA agent + +[Term] +id: CHEBI:50276 +name: EC 5.99.1.2 (DNA topoisomerase) inhibitor +namespace: chebi_ontology +def: "A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA." [] +subset: 3_STAR +synonym: "DNA topoisomerase inhibitor" RELATED [ChEBI] +synonym: "DNA topoisomerase inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.1.2 (DNA topoisomerase) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.1.2 (topoisomerase I) inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.1.2 (topoisomerase I) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.1.2 inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.1.2 inhibitors" RELATED [ChEBI] +synonym: "topoisomerase I (EC 5.99.1.2) inhibitor" RELATED [ChEBI] +synonym: "topoisomerase I (EC 5.99.1.2) inhibitors" RELATED [ChEBI] +synonym: "topoisomerase I inhibitor" RELATED [ChEBI] +synonym: "topoisomerase I inhibitors" RELATED [ChEBI] +synonym: "type I DNA topoisomerase inhibitor" RELATED [ChEBI] +synonym: "type I DNA topoisomerase inhibitors" RELATED [ChEBI] +is_a: CHEBI:70727 ! topoisomerase inhibitor + [Term] id: CHEBI:50297 name: canonical nucleotide residue @@ -16127,20 +28852,70 @@ synonym: "canonical nucleotide residues" RELATED [ChEBI] is_a: CHEBI:50319 ! nucleotide residue [Term] -id: CHEBI:50298 -name: canonical deoxyribonucleotide residue +id: CHEBI:50299 +name: canonical ribonucleotide residue namespace: chebi_ontology subset: 3_STAR -synonym: "canonical deoxyribonucleotide residues" RELATED [ChEBI] +synonym: "canonical ribonucleotide residues" RELATED [ChEBI] is_a: CHEBI:50297 ! canonical nucleotide residue [Term] -id: CHEBI:50299 -name: canonical ribonucleotide residue +id: CHEBI:50305 +name: podophyllotoxin +namespace: chebi_ontology +alt_id: CHEBI:45070 +alt_id: CHEBI:8280 +def: "An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts." [] +subset: 3_STAR +synonym: "(-)-podophyllotoxin" RELATED [ChEBI] +synonym: "(5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one" EXACT IUPAC_NAME [IUPAC] +synonym: "9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE" RELATED [PDBeChem] +synonym: "Condylox" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Podofilox" RELATED [ChemIDplus] +synonym: "Podophyllinic acid lactone" RELATED [ChemIDplus] +synonym: "Podophyllotoxin" EXACT [KEGG_COMPOUND] +synonym: "Podophyllotoxin 7" RELATED BRAND_NAME [DrugBank] +synonym: "PPT" RELATED [ChEBI] +xref: CAS:518-28-5 {source="KEGG COMPOUND"} +xref: CAS:518-28-5 {source="ChemIDplus"} +xref: Drug_Central:3481 {source="DrugCentral"} +xref: DrugBank:DB01179 +xref: HMDB:HMDB0031452 +xref: KEGG:C10874 +xref: KEGG:D05529 +xref: KNApSAcK:C00000610 +xref: LINCS:LSM-3055 +xref: PDBeChem:POD +xref: PMID:15803102 {source="Europe PMC"} +xref: PMID:22621772 {source="Europe PMC"} +xref: PMID:23161544 {source="Europe PMC"} +xref: PMID:23798883 {source="Europe PMC"} +xref: PMID:8112825 {source="Europe PMC"} +xref: Reaxys:99163 {source="Reaxys"} +xref: Wikipedia:Podophyllotoxin +is_a: CHEBI:25036 ! lignan +is_a: CHEBI:50307 ! furonaphthodioxole +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:50176 ! keratolytic drug +relationship: has_role CHEBI:61951 ! microtubule-destabilising agent +relationship: has_role CHEBI:76924 ! plant metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H22O8" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YJGVMLPVUAXIQN-XVVDYKMHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "414.40530" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "414.13147" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O" xsd:string + +[Term] +id: CHEBI:50307 +name: furonaphthodioxole namespace: chebi_ontology subset: 3_STAR -synonym: "canonical ribonucleotide residues" RELATED [ChEBI] -is_a: CHEBI:50297 ! canonical nucleotide residue +synonym: "furonaphthodioxole" EXACT [ChEBI] +synonym: "furonaphthodioxoles" RELATED [ChEBI] +is_a: CHEBI:38104 ! oxacycle +is_a: CHEBI:38163 ! organic heterotetracyclic compound [Term] id: CHEBI:50312 @@ -16254,6 +29029,100 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "107.12988" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "107.04969" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C*)C=CC(=C1)O" xsd:string +[Term] +id: CHEBI:50367 +name: taxane diterpenoid +namespace: chebi_ontology +subset: 3_STAR +synonym: "taxane diterpenoid" EXACT [ChEBI] +synonym: "taxane diterpenoids" RELATED [ChEBI] +is_a: CHEBI:23849 ! diterpenoid +relationship: has_parent_hydride CHEBI:36064 ! taxane + +[Term] +id: CHEBI:50390 +name: EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor +namespace: chebi_ontology +def: "An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2." [] +subset: 3_STAR +synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitor" RELATED [ChEBI] +synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) inhibitors" RELATED [ChEBI] +synonym: "diaphorase inhibitor" RELATED [ChEBI] +synonym: "diaphorase inhibitors" RELATED [ChEBI] +synonym: "DT diaphorase inhibitor" RELATED [ChEBI] +synonym: "EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitor" RELATED [ChEBI] +synonym: "EC 1.6.5.2 (NAD(P)H dehydrogenase (quinone)) inhibitors" RELATED [ChEBI] +synonym: "EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitors" RELATED [ChEBI] +synonym: "EC 1.6.5.2 inhibitor" RELATED [ChEBI] +synonym: "EC 1.6.5.2 inhibitors" RELATED [ChEBI] +synonym: "flavoprotein NAD(P)H-quinone reductase inhibitor" RELATED [ChEBI] +synonym: "flavoprotein NAD(P)H-quinone reductase inhibitors" RELATED [ChEBI] +synonym: "menadione oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "menadione oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "menadione reductase inhibitor" RELATED [ChEBI] +synonym: "menadione reductase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase (quinone) inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase (quinone) inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H menadione reductase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H menadione reductase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H-quinone dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H-quinone dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H-quinone oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H-quinone oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H2 dehydrogenase (quinone) inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H2 dehydrogenase (quinone) inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H: menadione oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H: menadione oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "NADH-menadione reductase inhibitor" RELATED [ChEBI] +synonym: "NADH-menadione reductase inhibitors" RELATED [ChEBI] +synonym: "naphthoquinone reductase inhibitor" RELATED [ChEBI] +synonym: "naphthoquinone reductase inhibitors" RELATED [ChEBI] +synonym: "NQO1 inhibitor" RELATED [ChEBI] +synonym: "NQO1 inhibitors" RELATED [ChEBI] +synonym: "p-benzoquinone reductase inhibitor" RELATED [ChEBI] +synonym: "p-benzoquinone reductase inhibitors" RELATED [ChEBI] +synonym: "phylloquinone reductase inhibitor" RELATED [ChEBI] +synonym: "phylloquinone reductase inhibitors" RELATED [ChEBI] +synonym: "QR1 inhibitor" RELATED [ChEBI] +synonym: "QR1 inhibitors" RELATED [ChEBI] +synonym: "quinone reductase inhibitor" RELATED [ChEBI] +synonym: "quinone reductase inhibitors" RELATED [ChEBI] +synonym: "reduced NAD(P)H dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "reduced NAD(P)H dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "viologen accepting pyridine nucleotide oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "viologen accepting pyridine nucleotide oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "vitamin K reductase inhibitor" RELATED [ChEBI] +synonym: "vitamin K reductase inhibitors" RELATED [ChEBI] +synonym: "vitamin-K reductase inhibitor" RELATED [ChEBI] +synonym: "vitamin-K reductase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76866 ! EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor + +[Term] +id: CHEBI:50393 +name: warfarin(1-) +namespace: chebi_ontology +def: "A racemate comprising equal amounts of (R)- and (S)-warfarin(1-)." [] +subset: 3_STAR +synonym: "2-oxo-3-(3-oxo-1-phenylbutyl)-2H-benzopyran-4-olate" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:87743 ! (R)-warfarin(1-) +relationship: has_part CHEBI:87744 ! (S)-warfarin(1-) +relationship: is_conjugate_base_of CHEBI:10033 ! warfarin +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H15O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "307.321" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.09703" xsd:string + [Term] id: CHEBI:50401 name: cholestanoid @@ -16282,6 +29151,15 @@ def: "Cholesterol esters and free cholesterol which are contained in or bound to subset: 3_STAR is_a: CHEBI:50401 ! cholestanoid +[Term] +id: CHEBI:50427 +name: platelet aggregation inhibitor +namespace: chebi_ontology +def: "A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system." [] +subset: 3_STAR +synonym: "platelet aggregation inhibitors" RELATED [ChEBI] +is_a: CHEBI:50248 ! hematologic agent + [Term] id: CHEBI:50457 name: diphenylfuran @@ -16323,6 +29201,31 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "220.266" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "220.08882" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "O1C(C2=CC=CC=C2)=CC=C1C3=CC=CC=C3" xsd:string +[Term] +id: CHEBI:50471 +name: primary arylamine +namespace: chebi_ontology +def: "A primary amine formally derived from ammonia by replacing one hydrogen atom by an aryl group. R-NH2 where R is an aryl group." [] +subset: 3_STAR +synonym: "an arylamine" RELATED [UniProt] +synonym: "primary arylamine" EXACT [ChEBI] +is_a: CHEBI:32877 ! primary amine +is_a: CHEBI:33860 ! aromatic amine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "H2NR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "16.023" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01872" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N(*)[H]" xsd:string + +[Term] +id: CHEBI:50491 +name: haloalkyl group +namespace: chebi_ontology +def: "A group derived from a haloalkane by removal of a hydrogen atom." [] +subset: 3_STAR +synonym: "haloalkyl groups" RELATED [ChEBI] +is_a: CHEBI:33249 ! organyl group + [Term] id: CHEBI:50505 name: sweetening agent @@ -16369,6 +29272,15 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H4O2" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/mass "84.074" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "84.02113" xsd:string +[Term] +id: CHEBI:50525 +name: phenolate anion +namespace: chebi_ontology +def: "An organic anion arising from deprotonation of the OH function of a phenol compound." [] +subset: 3_STAR +synonym: "phenolate anions" RELATED [ChEBI] +is_a: CHEBI:25696 ! organic anion + [Term] id: CHEBI:50584 name: alkyl alcohol @@ -16382,6 +29294,214 @@ synonym: "hydroxyalkane" RELATED [ChEBI] synonym: "hydroxyalkanes" RELATED [ChEBI] is_a: CHEBI:2571 ! aliphatic alcohol +[Term] +id: CHEBI:50629 +name: cyclooxygenase 2 inhibitor +namespace: chebi_ontology +def: "A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2." [] +subset: 3_STAR +synonym: "COX-2 inhibitor" RELATED [ChEBI] +synonym: "COX-2 inhibitors" RELATED [ChEBI] +synonym: "cyclo-oxygenase 2 inhibitor" RELATED [ChEBI] +synonym: "cyclo-oxygenase 2 inhibitors" RELATED [ChEBI] +synonym: "cyclo-oxygenase-2 inhibitor" RELATED [ChEBI] +synonym: "cyclo-oxygenase-2 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase 2 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase-2 inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase-2 inhibitors" RELATED [ChEBI] +synonym: "PGHS-2 inhibitor" RELATED [ChEBI] +synonym: "PGHS-2 inhibitors" RELATED [ChEBI] +synonym: "prostaglandin H synthase-2 inhibitor" RELATED [ChEBI] +synonym: "prostaglandin H synthase-2 inhibitors" RELATED [ChEBI] +synonym: "prostaglandin-endoperoxide synthase 2 inhibitor" RELATED [ChEBI] +synonym: "prostaglandin-endoperoxide synthase 2 inhibitors" RELATED [ChEBI] +xref: Wikipedia:Prostaglandin-endoperoxide_synthase_2 +is_a: CHEBI:35544 ! EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor + +[Term] +id: CHEBI:50630 +name: cyclooxygenase 1 inhibitor +namespace: chebi_ontology +def: "A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 1." [] +subset: 3_STAR +synonym: "COX-1 inhibitor" RELATED [ChEBI] +synonym: "COX-1 inhibitors" RELATED [ChEBI] +synonym: "cyclo-oxygenase 1 inhibitor" RELATED [ChEBI] +synonym: "cyclo-oxygenase 1 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase 1 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase-1 inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase-1 inhibitors" RELATED [ChEBI] +synonym: "prostaglandin G/H synthase 1 inhibitor" RELATED [ChEBI] +synonym: "prostaglandin G/H synthase 1 inhibitors" RELATED [ChEBI] +synonym: "prostaglandin H2 synthase 1 inhibitor" RELATED [ChEBI] +synonym: "prostaglandin H2 synthase 1 inhibitors" RELATED [ChEBI] +synonym: "prostaglandin-endoperoxide synthase 1 inhibitor" RELATED [ChEBI] +synonym: "prostaglandin-endoperoxide synthase 1 inhibitors" RELATED [ChEBI] +synonym: "PTGS1 inhibitor" RELATED [ChEBI] +synonym: "PTGS1 inhibitors" RELATED [ChEBI] +xref: Wikipedia:PTGS1 +is_a: CHEBI:35544 ! EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor + +[Term] +id: CHEBI:50646 +name: bone density conservation agent +namespace: chebi_ontology +alt_id: CHEBI:72497 +def: "An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis." [] +subset: 3_STAR +synonym: "anti-osteopenia agent" RELATED [ChEBI] +synonym: "anti-osteopenia agents" RELATED [ChEBI] +synonym: "anti-osteopenia drug" RELATED [ChEBI] +synonym: "anti-osteopenia drugs" RELATED [ChEBI] +synonym: "anti-osteoporosis agent" RELATED [ChEBI] +synonym: "anti-osteoporosis agents" RELATED [ChEBI] +synonym: "anti-osteoporosis drug" RELATED [ChEBI] +synonym: "anti-osteoporosis drugs" RELATED [ChEBI] +synonym: "anti-osteoporotic" RELATED [ChEBI] +synonym: "anti-osteoporotic agent" RELATED [ChEBI] +synonym: "anti-osteoporotic agents" RELATED [ChEBI] +synonym: "anti-osteoporotic drug" RELATED [ChEBI] +synonym: "anti-osteoporotic drugs" RELATED [ChEBI] +synonym: "anti-osteoporotics" RELATED [ChEBI] +synonym: "antiosteoporotic" RELATED [ChEBI] +synonym: "antiosteoporotics" RELATED [ChEBI] +synonym: "bone density conservation agents" RELATED [ChEBI] +synonym: "bone density conservation drug" RELATED [ChEBI] +synonym: "bone density conservation drugs" RELATED [ChEBI] +xref: Wikipedia:Osteoporosis +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:50667 +name: mercaptopurine +namespace: chebi_ontology +def: "A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis." [] +subset: 3_STAR +synonym: "1,7-dihydro-6H-purine-6-thione" EXACT IUPAC_NAME [IUPAC] +synonym: "6 MP" RELATED [ChemIDplus] +synonym: "6-Mercaptopurine" RELATED [ChemIDplus] +synonym: "6-MP" RELATED [ChemIDplus] +synonym: "6-Thiohypoxanthine" RELATED [ChemIDplus] +synonym: "6-Thioxopurine" RELATED [ChemIDplus] +synonym: "Mercaptopurina" RELATED INN [ChemIDplus] +synonym: "Mercaptopurine" EXACT [KEGG_COMPOUND] +synonym: "mercaptopurine" EXACT [UniProt] +synonym: "mercaptopurine" RELATED INN [ChEBI] +synonym: "mercaptopurinum" RELATED INN [ChemIDplus] +synonym: "Mercapurin" RELATED [DrugBank] +synonym: "Puri-Nethol" RELATED BRAND_NAME [DrugBank] +synonym: "Purinethol" RELATED BRAND_NAME [DrugBank] +xref: Beilstein:132916 {source="Beilstein"} +xref: CAS:50-44-2 {source="KEGG COMPOUND"} +xref: CAS:50-44-2 {source="ChemIDplus"} +xref: DrugBank:DB01033 +xref: KEGG:C02380 +xref: KEGG:D04931 +xref: Patent:US2697709 +xref: Patent:US2721866 +xref: PDBeChem:PM6 +xref: PMID:16267626 {source="Europe PMC"} +xref: PMID:28011186 {source="Europe PMC"} +xref: PMID:28166217 {source="Europe PMC"} +xref: PMID:28212467 {source="Europe PMC"} +xref: PMID:28295989 {source="Europe PMC"} +xref: PMID:28301625 {source="Europe PMC"} +xref: PMID:28406092 {source="Europe PMC"} +xref: PMID:28418010 {source="Europe PMC"} +xref: PMID:28484608 {source="Europe PMC"} +xref: PMID:28574837 {source="Europe PMC"} +xref: Reaxys:132916 {source="Reaxys"} +is_a: CHEBI:26401 ! purines +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: is_tautomer_of CHEBI:2208 ! purine-6-thiol +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C5H4N4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GLVAUDGFNGKCSF-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "152.17822" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "152.01567" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "S=c1[nH]cnc2nc[nH]c12" xsd:string + +[Term] +id: CHEBI:50680 +name: methotrexate(1-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "(2S)-4-carboxy-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)butanoate" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:5197927 {source="Beilstein"} +is_a: CHEBI:35695 ! dicarboxylic acid monoanion +relationship: is_conjugate_acid_of CHEBI:50681 ! methotrexate(2-) +relationship: is_conjugate_base_of CHEBI:44185 ! methotrexate +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21N8O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/p-1/t13-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOZXECLQNJBKD-ZDUSSCGKSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "453.43166" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "453.16404" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O" xsd:string + +[Term] +id: CHEBI:50681 +name: methotrexate(2-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "(2S)-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioate" EXACT IUPAC_NAME [IUPAC] +synonym: "methotrexate" RELATED [UniProt] +xref: Beilstein:6081035 {source="Beilstein"} +is_a: CHEBI:28965 ! dicarboxylic acid dianion +relationship: is_conjugate_base_of CHEBI:50680 ! methotrexate(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H20N8O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/p-2/t13-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FBOZXECLQNJBKD-ZDUSSCGKSA-L" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "452.42372" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "452.15676" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O" xsd:string + +[Term] +id: CHEBI:50683 +name: EC 1.5.1.3 (dihydrofolate reductase) inhibitor +namespace: chebi_ontology +def: "An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3)." [] +subset: 3_STAR +synonym: "7,8-dihydrofolate reductase inhibitor" RELATED [ChEBI] +synonym: "7,8-dihydrofolate reductase inhibitors" RELATED [ChEBI] +synonym: "DHFR inhibitor" RELATED [ChEBI] +synonym: "DHFR inhibitors" RELATED [ChEBI] +synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitor" RELATED [ChEBI] +synonym: "dihydrofolate reductase (EC 1.5.1.3) inhibitors" RELATED [ChEBI] +synonym: "dihydrofolate reductase inhibitor" RELATED [ChEBI] +synonym: "dihydrofolate reductase inhibitors" RELATED [ChEBI] +synonym: "dihydrofolic acid reductase inhibitor" RELATED [ChEBI] +synonym: "dihydrofolic acid reductase inhibitors" RELATED [ChEBI] +synonym: "dihydrofolic reductase inhibitor" RELATED [ChEBI] +synonym: "dihydrofolic reductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.5.1.3 (dihydrofolate reductase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.5.1.3 inhibitor" RELATED [ChEBI] +synonym: "EC 1.5.1.3 inhibitors" RELATED [ChEBI] +synonym: "folic acid reductase inhibitor" RELATED [ChEBI] +synonym: "folic acid reductase inhibitors" RELATED [ChEBI] +synonym: "folic reductase inhibitor" RELATED [ChEBI] +synonym: "folic reductase inhibitors" RELATED [ChEBI] +synonym: "NADPH-dihydrofolate reductase inhibitor" RELATED [ChEBI] +synonym: "NADPH-dihydrofolate reductase inhibitors" RELATED [ChEBI] +synonym: "tetrahydrofolate dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "tetrahydrofolate dehydrogenase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Dihydrofolate_reductase_inhibitor +is_a: CHEBI:73913 ! antifolate +is_a: CHEBI:76863 ! EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor + +[Term] +id: CHEBI:50684 +name: cross-linking reagent +namespace: chebi_ontology +def: "A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified." [] +subset: 3_STAR +synonym: "cross-linking reagents" RELATED [ChEBI] +is_a: CHEBI:33893 ! reagent + [Term] id: CHEBI:50689 name: reproductive control drug @@ -16392,6 +29512,36 @@ synonym: "reproductive control agent" RELATED [ChEBI] synonym: "reproductive control drugs" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:50690 +name: atorvastatin(1-) +namespace: chebi_ontology +subset: 3_STAR +synonym: "(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:29067 ! carboxylic acid anion +relationship: is_conjugate_base_of CHEBI:39548 ! atorvastatin +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H34FN2O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/p-1/t26-,27-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XUKUURHRXDUEBC-KAYWLYCHSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "557.63194" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "557.24572" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC([O-])=O" xsd:string + +[Term] +id: CHEBI:50691 +name: abortifacient +namespace: chebi_ontology +def: "A chemical substance that interrupts pregnancy after implantation." [] +subset: 3_STAR +synonym: "abortifacient agent" RELATED [ChEBI] +synonym: "abortifacient agents" RELATED [ChEBI] +synonym: "abortifacient drug" RELATED [ChEBI] +synonym: "abortifacient drugs" RELATED [ChEBI] +synonym: "abortifacients" RELATED [ChEBI] +xref: Wikipedia:Abortifacient +is_a: CHEBI:50689 ! reproductive control drug + [Term] id: CHEBI:50699 name: oligosaccharide @@ -16411,6 +29561,44 @@ xref: KEGG:C00930 is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:167559 ! glycan +[Term] +id: CHEBI:50730 +name: montelukast +namespace: chebi_ontology +alt_id: CHEBI:49756 +alt_id: CHEBI:6992 +subset: 3_STAR +synonym: "(R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid" RELATED [ChemIDplus] +synonym: "1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid" RELATED [Patent] +synonym: "MONTELUKAST" EXACT [PDBeChem] +synonym: "Montelukast" EXACT [KEGG_COMPOUND] +synonym: "montelukast" RELATED INN [ChEBI] +synonym: "{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid" EXACT IUPAC_NAME [IUPAC] +xref: Beilstein:7896575 {source="Beilstein"} +xref: CAS:158966-92-8 {source="KEGG COMPOUND"} +xref: CAS:158966-92-8 {source="ChemIDplus"} +xref: Drug_Central:1836 {source="DrugCentral"} +xref: DrugBank:DB00471 +xref: KEGG:C07482 +xref: KEGG:D08229 +xref: Patent:EP1886997 +xref: PDBeChem:MTK +xref: Wikipedia:Montelukast +is_a: CHEBI:22327 ! aliphatic sulfide +is_a: CHEBI:25384 ! monocarboxylic acid +is_a: CHEBI:26513 ! quinolines +relationship: has_role CHEBI:38070 ! anti-arrhythmia drug +relationship: has_role CHEBI:49159 ! leukotriene antagonist +relationship: has_role CHEBI:49167 ! anti-asthmatic drug +relationship: is_conjugate_acid_of CHEBI:49165 ! montelukast(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C35H36ClNO3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCHDWCPVSPXUMX-TZIWLTJVSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "586.18398" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "585.21044" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC1)CC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1" xsd:string + [Term] id: CHEBI:50733 name: nutraceutical @@ -16422,6 +29610,14 @@ synonym: "Food Supplementation" RELATED [ChEBI] synonym: "Nutritional supplement" RELATED [ChEBI] is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:50739 +name: estrogen receptor modulator +namespace: chebi_ontology +def: "A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure." [] +subset: 3_STAR +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:50745 name: progestogen @@ -16435,6 +29631,84 @@ synonym: "progestagens" RELATED [ChEBI] synonym: "progestogens" RELATED [ChEBI] is_a: CHEBI:50112 ! sex hormone +[Term] +id: CHEBI:50748 +name: antipsoriatic +namespace: chebi_ontology +def: "A drug used to treat psoriasis." [] +subset: 3_STAR +synonym: "antipsoriatic agent" RELATED [ChEBI] +synonym: "antipsoriatic drug" RELATED [ChEBI] +is_a: CHEBI:50177 ! dermatologic drug + +[Term] +id: CHEBI:50790 +name: EC 1.14.14.14 (aromatase) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC 1.14.14.14) and so reduces production of estrogenic steroid hormones." [] +subset: 3_STAR +synonym: "aromatase (EC 1.14.14.14) inhibitor" RELATED [ChEBI] +synonym: "aromatase (EC 1.14.14.14) inhibitors" RELATED [ChEBI] +synonym: "aromatase inhibitor" RELATED [ChEBI] +synonym: "aromatase inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.14 (aromatase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.14 inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.14.14 inhibitors" RELATED [ChEBI] +synonym: "estrogen synthase inhibitor" RELATED [ChEBI] +synonym: "estrogen synthase inhibitors" RELATED [ChEBI] +synonym: "estrogen synthetase inhibitor" RELATED [ChEBI] +synonym: "estrogen synthetase inhibitors" RELATED [ChEBI] +synonym: "oestrogen synthase inhibitor" RELATED [ChEBI] +synonym: "oestrogen synthase inhibitors" RELATED [ChEBI] +synonym: "oestrogen synthetase inhibitor" RELATED [ChEBI] +synonym: "oestrogen synthetase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Aromatase_inhibitor +is_a: CHEBI:76838 ! EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor + +[Term] +id: CHEBI:50792 +name: estrogen receptor antagonist +namespace: chebi_ontology +def: "An antagonist at the estrogen receptor." [] +subset: 3_STAR +synonym: "estrogen receptor antagonists" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug +is_a: CHEBI:48706 ! antagonist + +[Term] +id: CHEBI:50830 +name: fluorinated steroid +namespace: chebi_ontology +def: "A steroid which is substituted with one or more fluorine atoms in any position." [] +subset: 3_STAR +synonym: "fluorinated steroids" RELATED [ChEBI] +is_a: CHEBI:35341 ! steroid +is_a: CHEBI:37143 ! organofluorine compound + +[Term] +id: CHEBI:50837 +name: estrogen antagonist +namespace: chebi_ontology +def: "A compound which inhibits or antagonises the biosynthesis or actions of estrogens." [] +subset: 3_STAR +synonym: "oestrogen antagonist" RELATED [ChEBI] +is_a: CHEBI:49020 ! hormone antagonist + +[Term] +id: CHEBI:50846 +name: immunomodulator +namespace: chebi_ontology +def: "Biologically active substance whose activity affects or plays a role in the functioning of the immune system." [] +subset: 3_STAR +synonym: "Biomodulator" RELATED [ChEBI] +synonym: "Immune factor" RELATED [ChEBI] +synonym: "Immunologic factor" RELATED [ChEBI] +synonym: "Immunological factor" RELATED [ChEBI] +synonym: "immunomodulators" RELATED [ChEBI] +xref: Wikipedia:Immunotherapy +is_a: CHEBI:23888 ! drug +is_a: CHEBI:24432 ! biological role + [Term] id: CHEBI:50857 name: anti-allergic agent @@ -16471,6 +29745,15 @@ synonym: "organic molecular entities" RELATED [ChEBI] is_a: CHEBI:33582 ! carbon group molecular entity relationship: has_part CHEBI:27594 ! carbon atom +[Term] +id: CHEBI:50893 +name: azaarene +namespace: chebi_ontology +subset: 3_STAR +synonym: "azaarenes" RELATED [ChEBI] +is_a: CHEBI:33833 ! heteroarene +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + [Term] id: CHEBI:50902 name: genotoxin @@ -16529,6 +29812,33 @@ namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] subset: 3_STAR is_a: BFO:0000023 ! role +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl + +[Term] +id: CHEBI:50908 +name: hepatotoxic agent +namespace: chebi_ontology +def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals." [] +subset: 3_STAR +synonym: "agente hepatotoxico" RELATED [ChEBI] +synonym: "hepatotoxic agents" RELATED [ChEBI] +synonym: "hepatotoxicant" RELATED [ChEBI] +synonym: "hepatotoxicants" RELATED [ChEBI] +synonym: "hepatotoxin" RELATED [ChEBI] +synonym: "hepatotoxins" RELATED [ChEBI] +synonym: "hepatoxic agent" RELATED [ChEBI] +synonym: "hepatoxicant" RELATED [ChEBI] +is_a: CHEBI:52209 ! aetiopathogenetic role + +[Term] +id: CHEBI:50909 +name: nephrotoxic agent +namespace: chebi_ontology +def: "A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals." [] +subset: 3_STAR +synonym: "agente nefrotoxico" RELATED [ChEBI] +synonym: "nephrotoxicant" RELATED [ChEBI] +is_a: CHEBI:52209 ! aetiopathogenetic role [Term] id: CHEBI:50910 @@ -16548,6 +29858,195 @@ xref: Wikipedia:Neurotoxin is_a: CHEBI:52209 ! aetiopathogenetic role is_a: CHEBI:64909 ! poison +[Term] +id: CHEBI:50919 +name: antiemetic +namespace: chebi_ontology +def: "A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors." [] +subset: 3_STAR +synonym: "anti-emetic" RELATED [ChEBI] +synonym: "anti-emetics" RELATED [ChEBI] +synonym: "antiemetico" RELATED [ChEBI] +synonym: "antiemetics" RELATED [ChEBI] +xref: Wikipedia:Antiemetic +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:50925 +name: EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:75764 +def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine." [] +subset: 3_STAR +synonym: "A-kinase inhibitor" RELATED [ChEBI] +synonym: "A-kinase inhibitors" RELATED [ChEBI] +synonym: "AP50 kinase inhibitor" RELATED [ChEBI] +synonym: "AP50 kinase inhibitors" RELATED [ChEBI] +synonym: "ATP-protein transphosphorylase inhibitor" RELATED [ChEBI] +synonym: "ATP-protein transphosphorylase inhibitors" RELATED [ChEBI] +synonym: "ATP:protein phosphotransferase (non-specific) inhibitor" RELATED [ChEBI] +synonym: "ATP:protein phosphotransferase (non-specific) inhibitors" RELATED [ChEBI] +synonym: "betaIIPKC inhibitor" RELATED [ChEBI] +synonym: "betaIIPKC inhibitors" RELATED [ChEBI] +synonym: "BR serine/threonine-protein kinase 2 inhibitor" RELATED [ChEBI] +synonym: "BR serine/threonine-protein kinase 2 inhibitors" RELATED [ChEBI] +synonym: "calcium-dependent protein kinase C inhibitor" RELATED [ChEBI] +synonym: "calcium-dependent protein kinase C inhibitors" RELATED [ChEBI] +synonym: "calcium/phospholipid-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "calcium/phospholipid-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "cAMP-dependent protein kinase A inhibitor" RELATED [ChEBI] +synonym: "cAMP-dependent protein kinase A inhibitors" RELATED [ChEBI] +synonym: "cAMP-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "cAMP-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "casein kinase (phosphorylating) inhibitor" RELATED [ChEBI] +synonym: "casein kinase (phosphorylating) inhibitors" RELATED [ChEBI] +synonym: "casein kinase 2 inhibitor" RELATED [ChEBI] +synonym: "casein kinase 2 inhibitors" RELATED [ChEBI] +synonym: "casein kinase I inhibitor" RELATED [ChEBI] +synonym: "casein kinase I inhibitors" RELATED [ChEBI] +synonym: "casein kinase II inhibitor" RELATED [ChEBI] +synonym: "casein kinase II inhibitors" RELATED [ChEBI] +synonym: "casein kinase inhibitor" RELATED [ChEBI] +synonym: "casein kinase inhibitors" RELATED [ChEBI] +synonym: "cGMP-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "cGMP-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "CK-2 inhibitor" RELATED [ChEBI] +synonym: "CK-2 inhibitors" RELATED [ChEBI] +synonym: "CKI inhibitor" RELATED [ChEBI] +synonym: "CKI inhibitors" RELATED [ChEBI] +synonym: "CKII inhibitor" RELATED [ChEBI] +synonym: "CKII inhibitors" RELATED [ChEBI] +synonym: "cyclic AMP-dependent protein kinase A inhibitor" RELATED [ChEBI] +synonym: "cyclic AMP-dependent protein kinase A inhibitors" RELATED [ChEBI] +synonym: "cyclic AMP-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "cyclic AMP-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "cyclic monophosphate-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "cyclic monophosphate-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "cyclic nucleotide-dependent protein kinase inhibitor" RELATED [ChEBI] +synonym: "cyclic nucleotide-dependent protein kinase inhibitors" RELATED [ChEBI] +synonym: "cyclin-dependent kinase inhibitor" RELATED [ChEBI] +synonym: "cyclin-dependent kinase inhibitors" RELATED [ChEBI] +synonym: "dsk1 inhibitor" RELATED [ChEBI] +synonym: "dsk1 inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.1 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.11.1 inhibitors" RELATED [ChEBI] +synonym: "epsilon PKC inhibitor" RELATED [ChEBI] +synonym: "epsilon PKC inhibitors" RELATED [ChEBI] +synonym: "glycogen synthase a kinase inhibitor" RELATED [ChEBI] +synonym: "glycogen synthase a kinase inhibitors" RELATED [ChEBI] +synonym: "glycogen synthase kinase inhibitor" RELATED [ChEBI] +synonym: "glycogen synthase kinase inhibitors" RELATED [ChEBI] +synonym: "HIPK2 inhibitor" RELATED [ChEBI] +synonym: "HIPK2 inhibitors" RELATED [ChEBI] +synonym: "Hpr kinase inhibitor" RELATED [ChEBI] +synonym: "Hpr kinase inhibitors" RELATED [ChEBI] +synonym: "hydroxyalkyl-protein kinase inhibitor" RELATED [ChEBI] +synonym: "hydroxyalkyl-protein kinase inhibitors" RELATED [ChEBI] +synonym: "M phase-specific cdc2 kinase inhibitor" RELATED [ChEBI] +synonym: "M phase-specific cdc2 kinase inhibitors" RELATED [ChEBI] +synonym: "mitogen-activated S6 kinase inhibitor" RELATED [ChEBI] +synonym: "mitogen-activated S6 kinase inhibitors" RELATED [ChEBI] +synonym: "MKNK2 inhibitor" RELATED [ChEBI] +synonym: "MKNK2 inhibitors" RELATED [ChEBI] +synonym: "non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitor" RELATED [ChEBI] +synonym: "non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors" RELATED [ChEBI] +synonym: "non-specific serine/threonine protein kinase inhibitor" RELATED [ChEBI] +synonym: "non-specific serine/threonine protein kinase inhibitors" RELATED [ChEBI] +synonym: "p21 activated kinase-1 inhibitor" RELATED [ChEBI] +synonym: "p21 activated kinase-1 inhibitors" RELATED [ChEBI] +synonym: "p82 kinase inhibitor" RELATED [ChEBI] +synonym: "p82 kinase inhibitors" RELATED [ChEBI] +synonym: "PAK-1 inhibitor" RELATED [ChEBI] +synonym: "PAK-1 inhibitors" RELATED [ChEBI] +synonym: "PAK1 inhibitor" RELATED [ChEBI] +synonym: "PAK1 inhibitors" RELATED [ChEBI] +synonym: "phosphorylase b kinase kinase inhibitor" RELATED [ChEBI] +synonym: "phosphorylase b kinase kinase inhibitors" RELATED [ChEBI] +synonym: "PKA inhibitor" RELATED [ChEBI] +synonym: "PKA inhibitors" RELATED [ChEBI] +synonym: "protein glutamyl kinase inhibitor" RELATED [ChEBI] +synonym: "protein glutamyl kinase inhibitors" RELATED [ChEBI] +synonym: "protein kinase (phosphorylating) inhibitor" RELATED [ChEBI] +synonym: "protein kinase (phosphorylating) inhibitors" RELATED [ChEBI] +synonym: "protein kinase A inhibitor" RELATED [ChEBI] +synonym: "protein kinase A inhibitors" RELATED [ChEBI] +synonym: "protein kinase CK2 inhibitor" RELATED [ChEBI] +synonym: "protein kinase CK2 inhibitors" RELATED [ChEBI] +synonym: "protein kinase p58 inhibitor" RELATED [ChEBI] +synonym: "protein kinase p58 inhibitors" RELATED [ChEBI] +synonym: "protein phosphokinase inhibitor" RELATED [ChEBI] +synonym: "protein phosphokinase inhibitors" RELATED [ChEBI] +synonym: "protein serine kinase inhibitor" RELATED [ChEBI] +synonym: "protein serine kinase inhibitors" RELATED [ChEBI] +synonym: "protein serine-threonine kinase inhibitor" RELATED [ChEBI] +synonym: "protein serine-threonine kinase inhibitors" RELATED [ChEBI] +synonym: "protein-aspartyl kinase inhibitor" RELATED [ChEBI] +synonym: "protein-aspartyl kinase inhibitors" RELATED [ChEBI] +synonym: "protein-cysteine kinase inhibitor" RELATED [ChEBI] +synonym: "protein-cysteine kinase inhibitors" RELATED [ChEBI] +synonym: "protein-serine kinase inhibitor" RELATED [ChEBI] +synonym: "protein-serine kinase inhibitors" RELATED [ChEBI] +synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI] +synonym: "Prp4 protein kinase inhibitor" RELATED [ChEBI] +synonym: "Prp4 protein kinase inhibitors" RELATED [ChEBI] +synonym: "Raf kinase inhibitor" RELATED [ChEBI] +synonym: "Raf kinase inhibitors" RELATED [ChEBI] +synonym: "Raf-1 inhibitor" RELATED [ChEBI] +synonym: "Raf-1 inhibitors" RELATED [ChEBI] +synonym: "ribosomal protein S6 kinase II inhibitor" RELATED [ChEBI] +synonym: "ribosomal protein S6 kinase II inhibitors" RELATED [ChEBI] +synonym: "ribosomal S6 protein kinase inhibitor" RELATED [ChEBI] +synonym: "ribosomal S6 protein kinase inhibitors" RELATED [ChEBI] +synonym: "serine kinase inhibitor" RELATED [ChEBI] +synonym: "serine kinase inhibitors" RELATED [ChEBI] +synonym: "serine protein kinase inhibitor" RELATED [ChEBI] +synonym: "serine protein kinase inhibitors" RELATED [ChEBI] +synonym: "serine(threonine) protein kinase inhibitor" RELATED [ChEBI] +synonym: "serine(threonine) protein kinase inhibitors" RELATED [ChEBI] +synonym: "serine-specific protein kinase inhibitor" RELATED [ChEBI] +synonym: "serine-specific protein kinase inhibitors" RELATED [ChEBI] +synonym: "serine/threonine protein kinase inhibitor" RELATED [ChEBI] +synonym: "serine/threonine protein kinase inhibitors" RELATED [ChEBI] +synonym: "STK32 inhibitor" RELATED [ChEBI] +synonym: "STK32 inhibitors" RELATED [ChEBI] +synonym: "T-antigen kinase inhibitor" RELATED [ChEBI] +synonym: "T-antigen kinase inhibitors" RELATED [ChEBI] +synonym: "threonine-specific protein kinase inhibitor" RELATED [ChEBI] +synonym: "threonine-specific protein kinase inhibitors" RELATED [ChEBI] +synonym: "twitchin kinase inhibitor" RELATED [ChEBI] +synonym: "twitchin kinase inhibitors" RELATED [ChEBI] +synonym: "type-2 casein kinase inhibitor" RELATED [ChEBI] +synonym: "type-2 casein kinase inhibitors" RELATED [ChEBI] +synonym: "Wee 1-like kinase inhibitor" RELATED [ChEBI] +synonym: "Wee 1-like kinase inhibitors" RELATED [ChEBI] +synonym: "Wee-kinase inhibitor" RELATED [ChEBI] +synonym: "Wee-kinase inhibitors" RELATED [ChEBI] +synonym: "WEE1Hu inhibitor" RELATED [ChEBI] +synonym: "WEE1Hu inhibitors" RELATED [ChEBI] +is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor + +[Term] +id: CHEBI:50926 +name: angiogenesis modulating agent +namespace: chebi_ontology +def: "An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents." [] +subset: 3_STAR +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:50940 +name: tetracyclic antidepressant +namespace: chebi_ontology +def: "An antidepressant whose molecular structure consists of four ring-like structures in a T-shape." [] +subset: 3_STAR +synonym: "antidepresivo tetraciclico" RELATED [ChEBI] +synonym: "antidepresivos tetraciclicos" RELATED [ChEBI] +synonym: "piperazinoazepine antidepressant" RELATED [ChEBI] +synonym: "tetracyclic antidepressants" RELATED [ChEBI] +is_a: CHEBI:38163 ! organic heterotetracyclic compound +relationship: has_role CHEBI:35469 ! antidepressant + [Term] id: CHEBI:50949 name: serotonin uptake inhibitor @@ -16578,6 +30077,15 @@ synonym: "primary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion +[Term] +id: CHEBI:50995 +name: secondary amino compound +namespace: chebi_ontology +def: "A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups." [] +subset: 3_STAR +synonym: "secondary amino compounds" RELATED [ChEBI] +is_a: CHEBI:50047 ! organic amino compound + [Term] id: CHEBI:50996 name: tertiary amino compound @@ -16586,6 +30094,22 @@ def: "A compound formally derived from ammonia by replacing three hydrogen atoms subset: 3_STAR synonym: "tertiary amino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound +relationship: is_conjugate_base_of CHEBI:137982 ! tertiary ammonium ion + +[Term] +id: CHEBI:51026 +name: macrocycle +namespace: chebi_ontology +def: "A cyclic compound containing nine or more atoms as part of the cyclic system." [] +subset: 3_STAR +synonym: "macrocycle" EXACT IUPAC_NAME [IUPAC] +synonym: "macrocycles" RELATED [ChEBI] +synonym: "Makrocyclen" RELATED [ChEBI] +synonym: "makrocyclische Verbindungen" RELATED [ChEBI] +synonym: "Makrozyklen" RELATED [ChEBI] +synonym: "makrozyklische Verbindungen" RELATED [ChEBI] +xref: Wikipedia:Macrocycle +is_a: CHEBI:33595 ! cyclic compound [Term] id: CHEBI:51039 @@ -16640,8 +30164,52 @@ synonym: "nitrogen molecular entities" RELATED [ChEBI] synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND] xref: KEGG:C06061 is_a: CHEBI:33302 ! pnictogen molecular entity +is_a: FOODON:03412972 ! food additive relationship: has_part CHEBI:25555 ! nitrogen atom +[Term] +id: CHEBI:51144 +name: nitrogen group +namespace: chebi_ontology +subset: 3_STAR +synonym: "nitrogen group" EXACT [ChEBI] +synonym: "nitrogen groups" RELATED [ChEBI] +synonym: "nitrogen-containing group" RELATED [ChEBI] +synonym: "nitrogenous group" RELATED [ChEBI] +is_a: CHEBI:24433 ! group + +[Term] +id: CHEBI:5115 +name: monofluorobenzene +namespace: chebi_ontology +def: "The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent." [] +subset: 3_STAR +synonym: "Fluorbenzol" RELATED [ChEBI] +synonym: "Fluorobenzene" RELATED [KEGG_COMPOUND] +synonym: "fluorobenzene" EXACT IUPAC_NAME [IUPAC] +synonym: "monofluorobenzene" EXACT [NIST_Chemistry_WebBook] +synonym: "phenyl fluoride" RELATED [NIST_Chemistry_WebBook] +xref: Beilstein:1236623 {source="Beilstein"} +xref: CAS:462-06-6 {source="NIST Chemistry WebBook"} +xref: CAS:462-06-6 {source="ChemIDplus"} +xref: CAS:462-06-6 {source="KEGG COMPOUND"} +xref: Gmelin:49856 {source="Gmelin"} +xref: KEGG:C11272 +xref: Patent:CN101224914 +xref: Patent:US4390740 +xref: PMID:22976426 {source="Europe PMC"} +xref: PMID:24060903 {source="Europe PMC"} +xref: Reaxys:1236623 {source="Reaxys"} +xref: Wikipedia:Fluorobenzene +is_a: CHEBI:83575 ! monofluorobenzenes +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H5F" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H5F/c7-6-4-2-1-3-5-6/h1-5H" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PYLWMHQQBFSUBP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "96.10230" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.03753" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Fc1ccccc1" xsd:string + [Term] id: CHEBI:51151 name: dipolar compound @@ -16651,6 +30219,79 @@ subset: 3_STAR synonym: "dipolar compounds" RELATED [ChEBI] is_a: CHEBI:72695 ! organic molecule +[Term] +id: CHEBI:51214 +name: diamminedichloroplatinum +namespace: chebi_ontology +subset: 3_STAR +synonym: "diammine(dichloro)platinum" RELATED [ChEBI] +synonym: "diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC] +synonym: "diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC] +synonym: "diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC] +synonym: "diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC] +synonym: "diammineplatinum dichloride" RELATED [NIST_Chemistry_WebBook] +xref: CAS:14913-33-8 {source="NIST Chemistry WebBook"} +xref: Gmelin:101110 {source="Gmelin"} +is_a: CHEBI:33862 ! platinum coordination entity +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "Cl2H6N2Pt" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "300.045" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "298.95559" xsd:string + +[Term] +id: CHEBI:51269 +name: acenes +namespace: chebi_ontology +def: "Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives." [] +subset: 3_STAR +is_a: CHEBI:33836 ! benzenoid aromatic compound + +[Term] +id: CHEBI:51270 +name: tetracenes +namespace: chebi_ontology +def: "Compounds containing a tetracene skeleton." [] +subset: 3_STAR +synonym: "naphthacenes" RELATED [ChEBI] +is_a: CHEBI:51269 ! acenes + +[Term] +id: CHEBI:51285 +name: acenoquinone +namespace: chebi_ontology +def: "Quinones containing an acene fused ring system." [] +subset: 3_STAR +synonym: "acenoquinone" EXACT [ChEBI] +synonym: "acenoquinones" RELATED [ChEBI] +is_a: CHEBI:36141 ! quinone +is_a: CHEBI:51269 ! acenes + +[Term] +id: CHEBI:51286 +name: tetracenequinones +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:51285 ! acenoquinone +is_a: CHEBI:51958 ! organic polycyclic compound + +[Term] +id: CHEBI:51307 +name: diester +namespace: chebi_ontology +def: "A diester is a compound containing two ester groups." [] +subset: 3_STAR +synonym: "diester" EXACT [ChEBI] +synonym: "diesters" RELATED [ChEBI] +is_a: CHEBI:35701 ! ester + +[Term] +id: CHEBI:51374 +name: GABA agent +namespace: chebi_ontology +def: "A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems." [] +subset: 3_STAR +is_a: CHEBI:35942 ! neurotransmitter agent + [Term] id: CHEBI:51384 name: D-ascorbic acid @@ -16696,6 +30337,40 @@ namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:33247 ! organic group +[Term] +id: CHEBI:51451 +name: endothelin receptor antagonist +namespace: chebi_ontology +def: "A hormone antagonist that blocks endothelin receptors." [] +subset: 3_STAR +synonym: "ERA" RELATED [ChEBI] +is_a: CHEBI:49020 ! hormone antagonist + +[Term] +id: CHEBI:51454 +name: cyclopropanes +namespace: chebi_ontology +def: "Cyclopropane and its derivatives formed by substitution." [] +subset: 3_STAR +is_a: CHEBI:33598 ! carbocyclic compound + +[Term] +id: CHEBI:51545 +name: 1,2-benzoxazoles +namespace: chebi_ontology +def: "Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton, with the O atom positioned adjacent to one of the positions of ring fusion." [] +subset: 3_STAR +is_a: CHEBI:51549 ! benzisoxazole + +[Term] +id: CHEBI:51549 +name: benzisoxazole +namespace: chebi_ontology +def: "Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton." [] +subset: 3_STAR +synonym: "benzisoxazoles" RELATED [ChEBI] +is_a: CHEBI:46700 ! benzoxazole + [Term] id: CHEBI:51569 name: N-acyl-amino acid @@ -16718,6 +30393,25 @@ is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:83821 ! amino acid derivative relationship: has_functional_parent CHEBI:33709 ! amino acid +[Term] +id: CHEBI:51659 +name: dihydrofuran +namespace: chebi_ontology +def: "Compounds containing a mono-unsaturated furan ring skeleton." [] +subset: 3_STAR +synonym: "dihydrofurans" RELATED [ChEBI] +is_a: CHEBI:24129 ! furans + +[Term] +id: CHEBI:51683 +name: methoxybenzenes +namespace: chebi_ontology +def: "Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups." [] +subset: 3_STAR +synonym: "methoxybenzene" RELATED [ChEBI] +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:35618 ! aromatic ether + [Term] id: CHEBI:51689 name: enone @@ -16734,6 +30428,23 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "52.03150" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "51.99491" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])C([*])=O" xsd:string +[Term] +id: CHEBI:51702 +name: enoate ester +namespace: chebi_ontology +def: "An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position." [] +subset: 3_STAR +synonym: "enoate" RELATED [ChEBI] +synonym: "enoate esters" RELATED [ChEBI] +synonym: "enoates" RELATED [ChEBI] +is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester +is_a: CHEBI:78840 ! olefinic compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3O2R4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "68.03090" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "67.98983" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]\\C([*])=C(\\[*])C(=O)O[*]" xsd:string + [Term] id: CHEBI:51721 name: alpha,beta-unsaturated ketone @@ -16743,6 +30454,86 @@ subset: 3_STAR synonym: "alpha,beta-unsaturated ketones" RELATED [ChEBI] is_a: CHEBI:17087 ! ketone +[Term] +id: CHEBI:51737 +name: alpha,beta-unsaturated carboxylic ester +namespace: chebi_ontology +def: "A carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) or R(1)C#C-C(=O)OR(2) (R(2) =/= H) in which the ester C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] +subset: 3_STAR +synonym: "alpha,beta-unsaturated carboxylic esters" RELATED [ChEBI] +is_a: CHEBI:33308 ! carboxylic ester + +[Term] +id: CHEBI:51856 +name: methylphenidate(1+) +namespace: chebi_ontology +subset: 3_STAR +synonym: "2-(2-methoxy-2-oxo-1-phenylethyl)piperidinium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:6887 ! methylphenidate +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H20NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUGOZIWVEXMGBE-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "234.31414" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "234.14886" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)C(C1CCCC[NH2+]1)c1ccccc1" xsd:string + +[Term] +id: CHEBI:51857 +name: methyl (S)-phenyl[(S)-piperidin-2-yl]acetate +namespace: chebi_ontology +def: "A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have S configuration. It is the inactive enantiomer in the racemic drug methylphenidate." [] +subset: 3_STAR +synonym: "methyl (2S)-phenyl[(2S)-piperidin-2-yl]acetate" RELATED [ChEBI] +xref: Beilstein:6116308 {source="Beilstein"} +is_a: CHEBI:84276 ! methyl phenyl(piperidin-2-yl)acetate +relationship: is_enantiomer_of CHEBI:51860 ! dexmethylphenidate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H19NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUGOZIWVEXMGBE-STQMWFEESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "233.30620" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "233.14158" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)[C@H]([C@@H]1CCCCN1)c1ccccc1" xsd:string + +[Term] +id: CHEBI:51860 +name: dexmethylphenidate +namespace: chebi_ontology +def: "A methyl phenyl(piperidin-2-yl)acetate in which both stereocentres have R configuration. It is the active enantiomer in the racemic drug methylphenidate." [] +subset: 3_STAR +synonym: "(+)-threo-methylphenidate" RELATED [ChemIDplus] +synonym: "d-threo-methylphenidate" RELATED [ChemIDplus] +synonym: "dexmethylphenidate" RELATED INN [WHO_MedNet] +synonym: "dexmethylphenidatum" RELATED INN [WHO_MedNet] +synonym: "dexmetilfenidato" RELATED INN [WHO_MedNet] +synonym: "methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate" EXACT IUPAC_NAME [IUPAC] +synonym: "methyl (R)-phenyl[(R)-piperidin-2-yl]acetate" RELATED [ChEBI] +xref: Beilstein:6116309 {source="Beilstein"} +xref: CAS:40431-64-9 {source="ChemIDplus"} +xref: Drug_Central:836 {source="DrugCentral"} +xref: Wikipedia:Dexmethylphenidate +is_a: CHEBI:84276 ! methyl phenyl(piperidin-2-yl)acetate +relationship: has_role CHEBI:37962 ! adrenergic agent +relationship: is_enantiomer_of CHEBI:51857 ! methyl (S)-phenyl[(S)-piperidin-2-yl]acetate +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H19NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUGOZIWVEXMGBE-CHWSQXEVSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "233.30620" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "233.14158" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)[C@@H]([C@H]1CCCCN1)c1ccccc1" xsd:string + +[Term] +id: CHEBI:51867 +name: methyl ketone +namespace: chebi_ontology +def: "A ketone of formula RC(=O)CH3 (R =/= H)." [] +subset: 3_STAR +synonym: "methyl ketones" RELATED [ChEBI] +is_a: CHEBI:17087 ! ketone + [Term] id: CHEBI:51958 name: organic polycyclic compound @@ -16752,6 +30543,14 @@ synonym: "organic polycyclic compounds" RELATED [ChEBI] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound +[Term] +id: CHEBI:51959 +name: organic tricyclic compound +namespace: chebi_ontology +subset: 3_STAR +synonym: "organic tricyclic compounds" RELATED [ChEBI] +is_a: CHEBI:51958 ! organic polycyclic compound + [Term] id: CHEBI:52090 name: methoxide @@ -16759,6 +30558,7 @@ namespace: chebi_ontology def: "An organic anion that is the conjugate base of methanol." [] subset: 3_STAR synonym: "methoxide ion" RELATED [ChEBI] +xref: Reaxys:1839368 {source="Reaxys"} xref: Reaxys:1839368 "Reaxys" is_a: CHEBI:25696 ! organic anion relationship: has_role CHEBI:77746 ! human metabolite @@ -16779,6 +30579,8 @@ def: "An organic anion that is the conjugate base of ethanol." [] subset: 3_STAR synonym: "ethoxy anion" RELATED [ChEBI] xref: Beilstein:1839415 "Beilstein" +xref: Beilstein:1839415 {source="Beilstein"} +xref: Reaxys:1839415 {source="Reaxys"} xref: Reaxys:1839415 "Reaxys" is_a: CHEBI:25696 ! organic anion relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite @@ -16792,6 +30594,13 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "45.06050" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "45.03459" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC[O-]" xsd:string +[Term] +id: CHEBI:52157 +name: organic heteroheptacyclic compound +namespace: chebi_ontology +subset: 3_STAR +is_a: CHEBI:38166 ! organic heteropolycyclic compound + [Term] id: CHEBI:52206 name: biochemical role @@ -16831,6 +30640,17 @@ name: physiological role namespace: chebi_ontology subset: 1_STAR is_a: CHEBI:24432 ! biological role +property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl + +[Term] +id: CHEBI:52214 +name: ligand +namespace: chebi_ontology +def: "Any molecule or ion capable of binding to a central metal atom to form coordination complexes." [] +subset: 3_STAR +synonym: "ligands" RELATED [ChEBI] +xref: Wikipedia:Ligand +is_a: CHEBI:51086 ! chemical role [Term] id: CHEBI:52217 @@ -16845,6 +30665,19 @@ synonym: "medicament" RELATED [ChEBI] synonym: "pharmaceuticals" RELATED [ChEBI] is_a: CHEBI:33232 ! application +[Term] +id: CHEBI:52254 +name: apatite +def: "A phosphate mineral with the general formula Ca5(PO4)3X where X = OH, F or Cl." [] +synonym: "hydroxyapatite" RELATED [] +is_a: CHEBI:46723 ! phosphate mineral + +[Term] +id: CHEBI:52255 +name: hydroxylapatite +def: "A phosphate mineral with the formula Ca5(PO4)3(OH)." [] +is_a: CHEBI:52254 ! apatite + [Term] id: CHEBI:52290 name: mitogen @@ -16890,6 +30723,15 @@ def: "A glycolipid and which the glyco component is specified as galactosyl." [] subset: 3_STAR is_a: CHEBI:33563 ! glycolipid +[Term] +id: CHEBI:52557 +name: tetracyclic diterpenoid +namespace: chebi_ontology +def: "A diterpenoid with a tetracyclic skeleton." [] +subset: 3_STAR +synonym: "tetracyclic diterpenoids" RELATED [ChEBI] +is_a: CHEBI:23849 ! diterpenoid + [Term] id: CHEBI:52575 name: alkylglycerol @@ -16910,6 +30752,84 @@ synonym: "inorganic hydroxides" RELATED [ChEBI] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:24835 ! inorganic molecular entity +[Term] +id: CHEBI:52629 +name: EC 3.1.26.13 (retroviral ribonuclease H) inhibitor +namespace: chebi_ontology +def: "An inhibitor of ribonuclease H (EC 3.1.26.13), an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid." [] +subset: 3_STAR +synonym: "EC 3.1.26.13 (retroviral ribonuclease H) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.26.13 inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.26.13 inhibitors" RELATED [ChEBI] +synonym: "HIV RNase H inhibitor" RELATED [ChEBI] +synonym: "HIV RNase H inhibitors" RELATED [ChEBI] +synonym: "HIV-1 ribonuclease H inhibitor" RELATED [ChEBI] +synonym: "HIV-1 ribonuclease H inhibitors" RELATED [ChEBI] +synonym: "HIV-1 RNase H inhibitor" RELATED [ChEBI] +synonym: "HIV-1 RNase H inhibitors" RELATED [ChEBI] +synonym: "retroviral reverse transcriptase RNaseH inhibitor" RELATED [ChEBI] +synonym: "retroviral reverse transcriptase RNaseH inhibitors" RELATED [ChEBI] +synonym: "retroviral ribonuclease H (EC 3.1.26.13) inhibitor" RELATED [ChEBI] +synonym: "retroviral ribonuclease H (EC 3.1.26.13) inhibitors" RELATED [ChEBI] +synonym: "retroviral ribonuclease H inhibitor" RELATED [ChEBI] +synonym: "RT/RNase H inhibitor" RELATED [ChEBI] +synonym: "RT/RNase H inhibitors" RELATED [ChEBI] +xref: Wikipedia:Retroviral_ribonuclease_H +is_a: CHEBI:64947 ! anti-HIV-1 agent +is_a: CHEBI:76785 ! EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor + +[Term] +id: CHEBI:52717 +name: bortezomib +namespace: chebi_ontology +alt_id: CHEBI:41143 +def: "L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome." [] +subset: 3_STAR +synonym: "[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "bortezomib" EXACT [UniProt] +synonym: "bortezomib" RELATED INN [ChemIDplus] +synonym: "N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide" EXACT IUPAC_NAME [IUPAC] +synonym: "N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE" RELATED [PDBeChem] +synonym: "PS 341" RELATED [ChemIDplus] +synonym: "PS-341" RELATED [ChemIDplus] +synonym: "Velcade" RELATED BRAND_NAME [DrugBank] +xref: CAS:179324-69-7 {source="ChemIDplus"} +xref: Drug_Central:391 {source="DrugCentral"} +xref: DrugBank:DB00188 +xref: KEGG:D03150 +xref: LINCS:LSM-6281 +xref: PDBeChem:BO2 +xref: PMID:18484921 {source="Europe PMC"} +xref: PMID:18980173 {source="Europe PMC"} +xref: PMID:21504411 {source="Europe PMC"} +xref: PMID:21865767 {source="Europe PMC"} +xref: Reaxys:8723817 {source="Reaxys"} +xref: Wikipedia:Bortezomib +is_a: CHEBI:22475 ! amino acid amide +is_a: CHEBI:38314 ! pyrazines +is_a: CHEBI:84144 ! L-phenylalanine derivative +relationship: has_functional_parent CHEBI:38267 ! boronic acid +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35820 ! antiprotozoal drug +relationship: has_role CHEBI:37670 ! protease inhibitor +relationship: has_role CHEBI:52726 ! proteasome inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H25BN4O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GXJABQQUPOEUTA-RDJZCZTQSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "384.23700" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "384.19689" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O" xsd:string + +[Term] +id: CHEBI:52726 +name: proteasome inhibitor +namespace: chebi_ontology +def: "A drug that blocks the action of proteasomes, cellular complexes that break down proteins." [] +subset: 3_STAR +synonym: "proteasome inhibitors" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:52845 name: cyclic organic group @@ -16995,6 +30915,45 @@ synonym: "ionic polymer" RELATED [ChEBI] synonym: "polyionic macromolecule" RELATED [ChEBI] is_a: CHEBI:33839 ! macromolecule +[Term] +id: CHEBI:53746 +name: EC 1.1.1.205 (IMP dehydrogenase) inhibitor +namespace: chebi_ontology +def: "An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of IMP dehydrogenase (EC 1.1.1.205), so blocking de novo biosynthesis of purine nucleotides." [] +subset: 3_STAR +synonym: "EC 1.1.1.205 (IMP dehydrogenase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.1.1.205 inhibitor" RELATED [ChEBI] +synonym: "EC 1.1.1.205 inhibitors" RELATED [ChEBI] +synonym: "IMP dehydrogenase (EC 1.1.1.205) inhibitor" RELATED [ChEBI] +synonym: "IMP dehydrogenase (EC 1.1.1.205) inhibitors" RELATED [ChEBI] +synonym: "IMP dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "IMP dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "IMP oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "IMP oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "IMP:NAD(+) oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "IMP:NAD(+) oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "inosinate dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "inosinate dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "inosine 5'-monophosphate dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "inosine monophosphate dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "inosine monophosphate dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "inosine monophosphate oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "inosine monophosphate oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "inosinic acid dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "inosinic acid dehydrogenase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76835 ! EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor + +[Term] +id: CHEBI:53756 +name: HIV-1 reverse transcriptase inhibitor +namespace: chebi_ontology +def: "An entity which inhibits the activity of HIV-1 reverse transcriptase." [] +subset: 3_STAR +synonym: "HIV-1 reverse transcriptase inhibitors" RELATED [ChEBI] +synonym: "reverse transcriptase inhibitor" RELATED [ChEBI] +synonym: "reverse transcriptase inhibitors" RELATED [ChEBI] +is_a: CHEBI:52629 ! EC 3.1.26.13 (retroviral ribonuclease H) inhibitor + [Term] id: CHEBI:5386 name: globin @@ -17053,6 +31012,39 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "3482.74700" xsd:strin property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "3480.61570" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O" xsd:string +[Term] +id: CHEBI:55322 +name: mu-opioid receptor agonist +namespace: chebi_ontology +alt_id: CHEBI:50136 +def: "A compound that exhibits agonist activity at the mu-opioid receptor." [] +subset: 3_STAR +synonym: "mu opioid agonist" RELATED [ChEBI] +synonym: "mu-opioid agonists" RELATED [ChEBI] +synonym: "mu-opioid receptor agonists" RELATED [ChEBI] +is_a: CHEBI:60599 ! mu-opioid agent +is_a: CHEBI:60606 ! opioid receptor agonist + +[Term] +id: CHEBI:55324 +name: gastrointestinal drug +namespace: chebi_ontology +def: "A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion." [] +subset: 3_STAR +synonym: "gastrointestinal agent" RELATED [ChEBI] +synonym: "gastrointestinal agents" RELATED [ChEBI] +synonym: "gastrointestinal drugs" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:55347 +name: vitamin K antagonist +namespace: chebi_ontology +def: "A class of anticoagulants which act by inhibiting the action of vitamin K." [] +subset: 3_STAR +synonym: "vitamin K antagonists" RELATED [ChEBI] +is_a: CHEBI:48706 ! antagonist + [Term] id: CHEBI:55370 name: imidazolidinone @@ -17071,6 +31063,59 @@ subset: 3_STAR synonym: "1,2-benzisothiazoles" RELATED [ChEBI] is_a: CHEBI:37947 ! benzothiazoles +[Term] +id: CHEBI:5613 +name: haloperidol +namespace: chebi_ontology +def: "A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety." [] +subset: 3_STAR +synonym: "1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine" RELATED [ChemIDplus] +synonym: "4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone" RELATED [NIST_Chemistry_WebBook] +synonym: "4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone" RELATED [NIST_Chemistry_WebBook] +synonym: "4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone" RELATED [NIST_Chemistry_WebBook] +synonym: "4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one" RELATED [IUPHAR] +synonym: "4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one" EXACT IUPAC_NAME [IUPAC] +synonym: "gamma-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone" RELATED [NIST_Chemistry_WebBook] +synonym: "Haldol" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "haloperidol" RELATED INN [KEGG_DRUG] +synonym: "haloperidolum" RELATED INN [ChemIDplus] +xref: Beilstein:331267 {source="Beilstein"} +xref: CAS:52-86-8 {source="NIST Chemistry WebBook"} +xref: CAS:52-86-8 {source="ChemIDplus"} +xref: CAS:52-86-8 {source="KEGG COMPOUND"} +xref: Drug_Central:1353 {source="DrugCentral"} +xref: DrugBank:DB00502 +xref: KEGG:C01814 +xref: KEGG:D00136 +xref: LINCS:LSM-3512 +xref: Patent:BE577977 +xref: Patent:GB895309 +xref: Patent:US3438991 +xref: PMID:10628896 {source="Europe PMC"} +xref: PMID:11304647 {source="Europe PMC"} +xref: PMID:25007358 {source="Europe PMC"} +xref: PMID:6725621 {source="Europe PMC"} +xref: PMID:7602118 {source="Europe PMC"} +xref: Reaxys:331267 {source="Reaxys"} +xref: Wikipedia:Haloperidol +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:48590 ! hydroxypiperidine +is_a: CHEBI:76224 ! aromatic ketone +is_a: CHEBI:83403 ! monochlorobenzenes +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:50919 ! antiemetic +relationship: has_role CHEBI:65190 ! first generation antipsychotic +relationship: has_role CHEBI:66956 ! antidyskinesia agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H23ClFNO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LNEPOXFFQSENCJ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "375.86400" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "375.14013" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1" xsd:string + [Term] id: CHEBI:5686 name: heterocyclic compound @@ -17142,6 +31187,15 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "119.11920" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "119.05824" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CC(O)CC([O-])=O" xsd:string +[Term] +id: CHEBI:57652 +name: chondroitin D-glucuronate anion +def: "Anionic form of chondroitin D-glucuronate arising from deprotonation of the carboxylic acid groups of the repeating units; major species at pH 7.3." [] +synonym: "chondroitin D-glucuronate" RELATED [] +synonym: "chondroitin D-glucuronate polyanion" RELATED [] +is_a: CHEBI:61469 ! polyanionic polymer +relationship: is_conjugate_base_of CHEBI:16137 ! chondroitin D-glucuronate + [Term] id: CHEBI:57756 name: sphingosine(1+) @@ -17162,6 +31216,47 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "300.49980" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "300.28971" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCCCCCCCC\\C=C\\[C@@H](O)[C@@H]([NH3+])CO" xsd:string +[Term] +id: CHEBI:5778 +name: hydrochlorothiazide +namespace: chebi_ontology +def: "A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure." [] +subset: 3_STAR +synonym: "6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide" EXACT IUPAC_NAME [IUPAC] +synonym: "Esidrix (TN)" RELATED [KEGG_COMPOUND] +synonym: "hidroclorotiazida" RELATED INN [ChemIDplus] +synonym: "hydrochlorothiazide" RELATED INN [ChemIDplus] +synonym: "hydrochlorothiazidum" RELATED INN [ChemIDplus] +xref: CAS:58-93-5 {source="ChemIDplus"} +xref: CAS:58-93-5 {source="KEGG COMPOUND"} +xref: CAS:58-93-5 {source="NIST Chemistry WebBook"} +xref: Drug_Central:1385 {source="DrugCentral"} +xref: DrugBank:DB00999 +xref: HMDB:HMDB0001928 +xref: KEGG:C07041 +xref: KEGG:D00340 +xref: LINCS:LSM-5308 +xref: PDBeChem:HCZ +xref: PMID:24055851 {source="Europe PMC"} +xref: PMID:24657333 {source="Europe PMC"} +xref: PMID:24849193 {source="Europe PMC"} +xref: Reaxys:625101 {source="Reaxys"} +xref: Wikipedia:Hydrochlorothiazide +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:50265 ! benzothiadiazine +relationship: has_role CHEBI:35498 ! diuretic +relationship: has_role CHEBI:35674 ! antihypertensive agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H8ClN3O4S2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JZUFKLXOESDKRF-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "297.73900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "296.96448" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl" xsd:string + [Term] id: CHEBI:57887 name: tryptaminium @@ -17231,6 +31326,26 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "131.13320" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.06948" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(CC([O-])=O)C(N)=[NH2+]" xsd:string +[Term] +id: CHEBI:57966 +name: beta-alanine zwitterion +namespace: chebi_ontology +def: "Zwitterionic form of beta-alanine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "3-ammoniopropanoate" RELATED [IUPAC] +synonym: "3-azaniumylpropanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "beta-alanine" RELATED [UniProt] +xref: Gmelin:454332 {source="Gmelin"} +is_a: CHEBI:35238 ! amino acid zwitterion +relationship: is_tautomer_of CHEBI:16958 ! beta-alanine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H7NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "89.09320" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.04768" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CCC([O-])=O" xsd:string + [Term] id: CHEBI:57977 name: bilirubin(2-) @@ -17253,6 +31368,27 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "582.64630" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "582.24893" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(C=C)\\C(NC1=O)=C\\c1[nH]c(Cc2[nH]c(\\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC([O-])=O)c(CCC([O-])=O)c1C" xsd:string +[Term] +id: CHEBI:57981 +name: D-phenylalanine zwitterion +namespace: chebi_ontology +def: "A D-alpha-amino acid zwitterion that is D-phenylalanine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2R)-2-ammonio-3-phenylpropanoate" RELATED [IUPAC] +synonym: "(2R)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "D-phenylalanine" RELATED [UniProt] +xref: MetaCyc:CPD-216 +is_a: CHEBI:59871 ! D-alpha-amino acid zwitterion +relationship: is_enantiomer_of CHEBI:58095 ! L-phenylalanine zwitterion +relationship: is_tautomer_of CHEBI:16998 ! D-phenylalanine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-MRVPVSSYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18910" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@H](Cc1ccccc1)C([O-])=O" xsd:string + [Term] id: CHEBI:58065 name: homocysteine zwitterion @@ -17274,6 +31410,49 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "135.18500" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "135.03540" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C(CCS)C([O-])=O" xsd:string +[Term] +id: CHEBI:58095 +name: L-phenylalanine zwitterion +namespace: chebi_ontology +def: "An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-phenylalanine; major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2S)-2-ammonio-3-phenylpropanoate" RELATED [IUPAC] +synonym: "(2S)-2-azaniumyl-3-phenylpropanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "L-phenylalanine" RELATED [UniProt] +synonym: "phenylalanine" RELATED [ChEBI] +xref: MetaCyc:PHE +xref: PMID:21956539 {source="Europe PMC"} +is_a: CHEBI:35238 ! amino acid zwitterion +relationship: is_enantiomer_of CHEBI:57981 ! D-phenylalanine zwitterion +relationship: is_tautomer_of CHEBI:17295 ! L-phenylalanine +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "COLNVLDHVKWLRT-QMMMGPOBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "165.18910" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "165.07898" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][C@@H](Cc1ccccc1)C([O-])=O" xsd:string + +[Term] +id: CHEBI:58097 +name: morphine(1+) +namespace: chebi_ontology +def: "The conjugate acid of morphine arising from protonation of the tertiary amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-17-ium-3,6alpha-diol" EXACT IUPAC_NAME [IUPAC] +synonym: "morphine" RELATED [UniProt] +synonym: "morphine cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:17303 ! morphine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H20NO3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/p+1/t10-,11+,13-,16-,17-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BQJCRHHNABKAKU-KBQPJGBKSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "286.34560" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "286.14377" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12C=C[C@H](O)[C@@H]3Oc4c(O)ccc5C[C@H]1[NH+](C)CC[C@@]23c45" xsd:string + [Term] id: CHEBI:58123 name: (2S)-2-hydroxy monocarboxylic acid anion @@ -17369,6 +31548,27 @@ synonym: "straight-chain saturated fatty acid anions" RELATED [ChEBI] is_a: CHEBI:58953 ! saturated fatty acid anion relationship: is_conjugate_base_of CHEBI:39418 ! straight-chain saturated fatty acid +[Term] +id: CHEBI:58955 +name: branched-chain fatty acid anion +namespace: chebi_ontology +def: "Any fatty acid anion with a carbon side-chain or isopropyl termination." [] +subset: 3_STAR +synonym: "branched-chain fatty acid anions" RELATED [ChEBI] +is_a: CHEBI:28868 ! fatty acid anion +relationship: is_conjugate_base_of CHEBI:35819 ! branched-chain fatty acid + +[Term] +id: CHEBI:58956 +name: branched-chain saturated fatty acid anion +namespace: chebi_ontology +def: "Any saturated fatty acid anion with a carbon side-chain or isopropyl termination." [] +subset: 3_STAR +synonym: "branched-chain saturated fatty acid anions" RELATED [ChEBI] +is_a: CHEBI:58953 ! saturated fatty acid anion +is_a: CHEBI:58955 ! branched-chain fatty acid anion +relationship: is_conjugate_base_of CHEBI:39417 ! branched-chain saturated fatty acid + [Term] id: CHEBI:58958 name: organosulfate oxoanion @@ -17386,6 +31586,34 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string +[Term] +id: CHEBI:59107 +name: EC 3.4.24.* (metalloendopeptidase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:76786 +def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*)." [] +subset: 3_STAR +synonym: "EC 3.4.24.* (metalloendopeptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.24.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.24.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of metalloendopeptidases" RELATED [ChEBI] +synonym: "inhibitor of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] +synonym: "inhibitors of metalloendopeptidases" RELATED [ChEBI] +synonym: "inhibitors of metalloendopeptidases (EC 3.4.24.*)" RELATED [ChEBI] +synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitor" RELATED [ChEBI] +synonym: "metalloendopeptidase (EC 3.4.24.*) inhibitors" RELATED [ChEBI] +synonym: "metalloendopeptidase inhibitors" RELATED [ChEBI] +is_a: CHEBI:37670 ! protease inhibitor + +[Term] +id: CHEBI:59163 +name: biomarker +namespace: chebi_ontology +def: "A substance used as an indicator of a biological state." [] +subset: 3_STAR +synonym: "biological marker" RELATED [ChEBI] +is_a: CHEBI:47867 ! indicator + [Term] id: CHEBI:59202 name: straight-chain fatty acid @@ -17422,6 +31650,21 @@ xref: PMID:17113094 {source="Europe PMC"} xref: PMID:9300789 {source="Europe PMC"} is_a: CHEBI:35366 ! fatty acid +[Term] +id: CHEBI:5924 +name: EC 3.4.21.* (serine endopeptidase) inhibitor +namespace: chebi_ontology +def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that inhibits the activity of a serine endopeptidase (EC 3.4.21.*)." [] +subset: 3_STAR +synonym: "EC 3.4.21.* (serine endopeptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.21.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.21.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of serine endopeptidase (EC 3.4.21.*)" RELATED [ChEBI] +synonym: "inhibitor of serine endopeptidase (EC 3.4.21.*)s" RELATED [ChEBI] +synonym: "serine endopeptidase inhibitor" RELATED [ChEBI] +synonym: "serine endopeptidase inhibitors" RELATED [ChEBI] +is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor + [Term] id: CHEBI:59252 name: linear tetrapyrrole anion @@ -17433,6 +31676,31 @@ synonym: "acyclic tetrapyrrole anions" RELATED [ChEBI] synonym: "linear tetrapyrrole anions" RELATED [ChEBI] is_a: CHEBI:25696 ! organic anion +[Term] +id: CHEBI:59285 +name: EC 1.14.13.132 (squalene monooxygenase) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132)." [] +subset: 3_STAR +synonym: "EC 1.14.13.132 (squalene monooxygenase) inhibitors" RELATED [ChEBI] +synonym: "squalene 2,3-oxidocyclase inhibitor" RELATED [ChEBI] +synonym: "squalene 2,3-oxidocyclase inhibitors" RELATED [ChEBI] +synonym: "squalene epoxidase inhibitor" RELATED [ChEBI] +synonym: "squalene epoxidase inhibitors" RELATED [ChEBI] +synonym: "squalene hydroxylase inhibitor" RELATED [ChEBI] +synonym: "squalene hydroxylase inhibitors" RELATED [ChEBI] +synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitor" RELATED [ChEBI] +synonym: "squalene monooxygenase (EC 1.14.13.132) inhibitors" RELATED [ChEBI] +synonym: "squalene monooxygenase inhibitor" RELATED [ChEBI] +synonym: "squalene monooxygenase inhibitors" RELATED [ChEBI] +synonym: "squalene oxydocyclase inhibitor" RELATED [ChEBI] +synonym: "squalene oxydocyclase inhibitors" RELATED [ChEBI] +synonym: "squalene-2,3-epoxidase inhibitor" RELATED [ChEBI] +synonym: "squalene-2,3-epoxidase inhibitors" RELATED [ChEBI] +synonym: "squalene-2,3-epoxide cyclase inhibitor" RELATED [ChEBI] +synonym: "squalene-2,3-epoxide cyclase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76841 ! EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor + [Term] id: CHEBI:5931 name: insulin (human) @@ -17484,6 +31752,15 @@ synonym: "prostaglandin carboxylic acid anions" RELATED [ChEBI] is_a: CHEBI:62943 ! prostanoid anion relationship: is_conjugate_base_of CHEBI:26333 ! prostaglandin +[Term] +id: CHEBI:59517 +name: DNA synthesis inhibitor +namespace: chebi_ontology +def: "Any substance that inhibits the synthesis of DNA." [] +subset: 3_STAR +synonym: "DNA synthesis inhibitors" RELATED [ChEBI] +is_a: CHEBI:76932 ! pathway inhibitor + [Term] id: CHEBI:59549 name: essential fatty acid @@ -17559,6 +31836,68 @@ synonym: "nucleophilic reagents" RELATED [ChEBI] is_a: CHEBI:33893 ! reagent is_a: CHEBI:39144 ! Lewis base +[Term] +id: CHEBI:59769 +name: acetal +namespace: chebi_ontology +def: "An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H). Mixed acetals have R'' and R''' groups which differ." [] +subset: 3_STAR +synonym: "acetals" RELATED [ChEBI] +is_a: CHEBI:36963 ! organooxygen compound + +[Term] +id: CHEBI:59770 +name: cyclic acetal +namespace: chebi_ontology +def: "An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring." [] +subset: 3_STAR +synonym: "cyclic acetals" RELATED [ChEBI] +is_a: CHEBI:24532 ! organic heterocyclic compound +is_a: CHEBI:59769 ! acetal + +[Term] +id: CHEBI:59777 +name: ketal +namespace: chebi_ontology +def: "An acetal of formula R2C(OR)2 (R =/= H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals." [] +subset: 3_STAR +synonym: "ketals" RELATED [ChEBI] +is_a: CHEBI:59769 ! acetal + +[Term] +id: CHEBI:59779 +name: cyclic ketal +namespace: chebi_ontology +def: "A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring." [] +subset: 3_STAR +synonym: "cyclic ketals" RELATED [ChEBI] +is_a: CHEBI:38104 ! oxacycle +is_a: CHEBI:59777 ! ketal + +[Term] +id: CHEBI:59806 +name: (S)-nicotinium(1+) +namespace: chebi_ontology +def: "The conjugate acid of (S)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2S)-1-methyl-2-(pyridin-3-yl)pyrrolidinium" EXACT IUPAC_NAME [IUPAC] +synonym: "(S)-nicotine" RELATED [UniProt] +synonym: "(S)-nicotinium cation" RELATED [ChEBI] +xref: Gmelin:329042 "Gmelin" +xref: Gmelin:329042 {source="Gmelin"} +xref: MetaCyc:NICOTINE +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: has_role CHEBI:76924 ! plant metabolite +relationship: is_conjugate_acid_of CHEBI:17688 ! (S)-nicotine +relationship: is_enantiomer_of CHEBI:79008 ! (R)-nicotinium(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H15N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNICXCGAKADSCV-JTQLQIEISA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "163.23900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "163.12297" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+]1CCC[C@H]1c1cccnc1" xsd:string + [Term] id: CHEBI:59814 name: L-alpha-amino acid anion @@ -17584,6 +31923,16 @@ synonym: "progestins" RELATED [ChEBI] xref: Wikipedia:Progestin is_a: CHEBI:50745 ! progestogen +[Term] +id: CHEBI:59831 +name: enyne +namespace: chebi_ontology +def: "An acetylenic and an olefinic compound containing a carbon chain that contains a carbon-carbon double bond and a carbon-carbon triple bond." [] +subset: 3_STAR +synonym: "enynes" RELATED [ChEBI] +is_a: CHEBI:73474 ! acetylenic compound +is_a: CHEBI:78840 ! olefinic compound + [Term] id: CHEBI:59869 name: L-alpha-amino acid zwitterion @@ -17649,6 +31998,43 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "100.05290" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "100.00347" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[C@@H]([*])NC([*])=O" xsd:string +[Term] +id: CHEBI:59897 +name: EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +namespace: chebi_ontology +def: "A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce." [] +subset: 3_STAR +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor" RELATED [ChEBI] +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitors" RELATED [ChEBI] +synonym: "DNA nucleotidyltransferase (RNA-directed) inhibitor" RELATED [ChEBI] +synonym: "DNA nucleotidyltransferase (RNA-directed) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.7.49 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.7.49 inhibitors" RELATED [ChEBI] +synonym: "reverse transcriptase inhibitor" RELATED [ChEBI] +synonym: "reverse transcriptase inhibitors" RELATED [ChEBI] +synonym: "revertase inhibitor" RELATED [ChEBI] +synonym: "revertase inhibitors" RELATED [ChEBI] +synonym: "RNA revertase inhibitor" RELATED [ChEBI] +synonym: "RNA revertase inhibitors" RELATED [ChEBI] +synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase inhibitors" RELATED [ChEBI] +synonym: "RNA-dependent DNA polymerase inhibitor" RELATED [ChEBI] +synonym: "RNA-dependent DNA polymerase inhibitors" RELATED [ChEBI] +synonym: "RNA-directed DNA polymerase (EC 2.7.7.49) inhibitor" RELATED [ChEBI] +synonym: "RNA-directed DNA polymerase (EC 2.7.7.49) inhibitors" RELATED [ChEBI] +synonym: "RNA-directed DNA polymerase inhibitor" RELATED [ChEBI] +synonym: "RNA-directed DNA polymerase inhibitors" RELATED [ChEBI] +synonym: "RNA-instructed DNA polymerase inhibitor" RELATED [ChEBI] +synonym: "RNA-instructed DNA polymerase inhibitors" RELATED [ChEBI] +synonym: "RT inhibitor" RELATED [ChEBI] +synonym: "RT inhibitors" RELATED [ChEBI] +synonym: "telomerase inhibitor" RELATED [ChEBI] +synonym: "telomerase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Reverse-transcriptase_inhibitor +is_a: CHEBI:22587 ! antiviral agent +is_a: CHEBI:38234 ! DNA polymerase inhibitor + [Term] id: CHEBI:59905 name: dopaminium(1+) @@ -17711,7 +32097,9 @@ synonym: "(1R,2R,3S,5S)-3-(benzoyloxy)-2-(methoxycarbonyl)-8-methyl-8-azoniabicy synonym: "cocaine" RELATED [UniProt] synonym: "cocaine cation" RELATED [ChEBI] xref: Gmelin:2542129 "Gmelin" +xref: Gmelin:2542129 {source="Gmelin"} xref: Gmelin:341636 "Gmelin" +xref: Gmelin:341636 {source="Gmelin"} is_a: CHEBI:35274 ! ammonium ion derivative is_a: CHEBI:37332 ! tropane alkaloid relationship: has_role CHEBI:77746 ! human metabolite @@ -17724,6 +32112,15 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "304.36090" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "304.15433" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)[NH+]2C" xsd:string +[Term] +id: CHEBI:60082 +name: vinca alkaloid cation +namespace: chebi_ontology +def: "Any cation arising from protonation of at least one of the amino functions in a vinca alkaloid." [] +subset: 3_STAR +synonym: "vinca alkaloid cations" RELATED [ChEBI] +is_a: CHEBI:35274 ! ammonium ion derivative + [Term] id: CHEBI:60164 name: ionic polymer @@ -17743,6 +32140,43 @@ subset: 3_STAR synonym: "a monovalent cation" RELATED [UniProt] is_a: CHEBI:36915 ! inorganic cation +[Term] +id: CHEBI:60251 +name: guanidinium ion +namespace: chebi_ontology +def: "R = C or H. The iminium ion resulting from the protonation of one of the imine nitrogens of guanidine or its derivatives." [] +subset: 3_STAR +synonym: "diaminomethaniminium ion" RELATED [ChEBI] +synonym: "diaminomethaniminium ions" RELATED [ChEBI] +synonym: "guanidinium ions" RELATED [ChEBI] +is_a: CHEBI:35286 ! iminium ion +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "CHN3R5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "55.039" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "55.01705" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=[N+]([H])*)(N(*)*)N(*)*" xsd:string + +[Term] +id: CHEBI:60258 +name: EC 3.4.* (hydrolases acting on peptide bond) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:76763 +def: "A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*)." [] +subset: 3_STAR +synonym: "EC 3.4.* (hydrolase acting on peptide bond) inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.* (hydrolase acting on peptide bonds) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.* (hydrolases acting on peptide bond) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.* (peptidase) inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.* (peptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] +synonym: "inhibitors of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI] +synonym: "peptidase inhibitors" RELATED [ChEBI] +synonym: "protease inhibitor" RELATED [ChEBI] +synonym: "protease inhibitors" RELATED [ChEBI] +is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor + [Term] id: CHEBI:60308 name: 3,3',5-triiodo-L-thyroninate @@ -17790,12 +32224,45 @@ name: peptide zwitterion namespace: chebi_ontology def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." [] subset: 3_STAR +synonym: "a peptide" RELATED [UniProt] synonym: "peptide zwitterions" RELATED [ChEBI] is_a: CHEBI:27369 ! zwitterion relationship: is_tautomer_of CHEBI:16670 ! peptide property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R(C2H2NOR)n" xsd:string +[Term] +id: CHEBI:60598 +name: opioid agent +namespace: chebi_ontology +def: "Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter." [] +subset: 3_STAR +synonym: "opioid agents" RELATED [ChEBI] +is_a: CHEBI:35942 ! neurotransmitter agent + +[Term] +id: CHEBI:60599 +name: mu-opioid agent +namespace: chebi_ontology +def: "Any agent that acts on a mu-opioid receptor." [] +subset: 3_STAR +synonym: "mu-opioid agents" RELATED [ChEBI] +is_a: CHEBI:60598 ! opioid agent + +[Term] +id: CHEBI:60606 +name: opioid receptor agonist +namespace: chebi_ontology +def: "An agent that selectively binds to and activates an opioid receptor." [] +subset: 3_STAR +synonym: "opiate agonist" RELATED [ChEBI] +synonym: "opiate agonists" RELATED [ChEBI] +synonym: "opioid agonist" RELATED [ChEBI] +synonym: "opioid agonists" RELATED [ChEBI] +synonym: "opioid receptor agonists" RELATED [ChEBI] +is_a: CHEBI:48705 ! agonist +is_a: CHEBI:60598 ! opioid agent + [Term] id: CHEBI:60643 name: NMDA receptor antagonist @@ -17810,6 +32277,89 @@ synonym: "NMDAR antagonist" RELATED [ChEBI] synonym: "NMDAR antagonists" RELATED [ChEBI] is_a: CHEBI:60798 ! excitatory amino acid antagonist +[Term] +id: CHEBI:60644 +name: bridged diphenyl antifungal agent +namespace: chebi_ontology +def: "Any organic aromatic compound containing two phenyl (or substituted phenyl) groups attached to a single carbon or heteroatom and which has significant antifungal properties." [] +subset: 3_STAR +synonym: "bridged diphenyl antifungal agents" RELATED [ChEBI] +is_a: CHEBI:33659 ! organic aromatic compound +relationship: has_role CHEBI:35718 ! antifungal agent + +[Term] +id: CHEBI:60761 +name: floxuridine +namespace: chebi_ontology +def: "A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [] +subset: 3_STAR +synonym: "1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil" RELATED [ChemIDplus] +synonym: "1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil" RELATED [ChemIDplus] +synonym: "1beta-D-2'-Deoxyribofuranosyl-5-flurouracil" RELATED [ChemIDplus] +synonym: "2'-Deoxy-5-fluorouridine" RELATED [ChemIDplus] +synonym: "5-fluoro-2'-deoxyuridine" EXACT IUPAC_NAME [IUPAC] +synonym: "5-fluoro-2'-deoxyuridine" RELATED [ChEBI] +synonym: "5-Fluoro-2-desoxyuridine" RELATED [ChemIDplus] +synonym: "5-Fluorodeoxyuridine" RELATED [KEGG_COMPOUND] +synonym: "5-Fluorouracil 2'-deoxyriboside" RELATED [ChemIDplus] +synonym: "5-Fluorouracil deoxyriboside" RELATED [NIST_Chemistry_WebBook] +synonym: "5FDU" RELATED [DrugBank] +synonym: "beta-5-Fluoro-2'-deoxyuridine" RELATED [ChemIDplus] +synonym: "Deoxyfluorouridine" RELATED [DrugBank] +synonym: "FdU" RELATED [ChEBI] +synonym: "floxiridina" RELATED INN [DrugBank] +synonym: "Floxuridin" RELATED [ChemIDplus] +synonym: "Floxuridine" EXACT [KEGG_COMPOUND] +synonym: "floxuridine" RELATED INN [KEGG_DRUG] +synonym: "floxuridinum" RELATED INN [DrugBank] +synonym: "Fluorodeoxyuridine" RELATED [DrugBank] +synonym: "Fluoruridine Deoxyribose" RELATED [DrugBank] +synonym: "Fluoruridine deoxyribose" RELATED [ChemIDplus] +xref: CAS:50-91-9 {source="KEGG COMPOUND"} +xref: CAS:50-91-9 {source="KEGG DRUG"} +xref: CAS:50-91-9 {source="NIST Chemistry WebBook"} +xref: CAS:50-91-9 {source="ChemIDplus"} +xref: Drug_Central:1184 {source="DrugCentral"} +xref: DrugBank:DB00322 +xref: HMDB:HMDB0014467 +xref: KEGG:C11736 +xref: KEGG:D04197 +xref: LINCS:LSM-5588 +xref: PMID:12520460 {source="Europe PMC"} +xref: PMID:19744858 {source="Europe PMC"} +xref: PMID:19917528 {source="Europe PMC"} +xref: PMID:20218622 {source="Europe PMC"} +xref: PMID:20363130 {source="Europe PMC"} +xref: PMID:20391188 {source="Europe PMC"} +xref: PMID:28166217 {source="Europe PMC"} +xref: PMID:29438107 {source="Europe PMC"} +xref: PMID:3950402 {source="Europe PMC"} +xref: Reaxys:90221 {source="Reaxys"} +xref: Wikipedia:Floxuridine +is_a: CHEBI:19255 ! pyrimidine 2'-deoxyribonucleoside +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:60783 ! nucleoside analogue +relationship: has_role CHEBI:132992 ! radiosensitizing agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:36044 ! antiviral drug +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H11FN2O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ODKNJVUHOIMIIZ-RRKCRQDMSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "246.19240" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "246.06520" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O" xsd:string + +[Term] +id: CHEBI:60783 +name: nucleoside analogue +namespace: chebi_ontology +def: "An analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells." [] +subset: 3_STAR +synonym: "nucleoside analogues" RELATED [ChEBI] +is_a: CHEBI:21731 ! N-glycosyl compound + [Term] id: CHEBI:60798 name: excitatory amino acid antagonist @@ -17823,6 +32373,15 @@ synonym: "excitatory amino acid receptor antagonist" RELATED [ChEBI] synonym: "excitatory amino acid receptor antagonists" RELATED [ChEBI] is_a: CHEBI:48706 ! antagonist +[Term] +id: CHEBI:60832 +name: tubulin modulator +namespace: chebi_ontology +def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." [] +subset: 3_STAR +synonym: "tubulin modulators" RELATED [ChEBI] +is_a: CHEBI:52210 ! pharmacological role + [Term] id: CHEBI:60895 name: D-alpha-amino acid anion @@ -17850,6 +32409,114 @@ synonym: "racemates" RELATED [ChEBI] synonym: "racemic mixture" RELATED [ChEBI] is_a: CHEBI:60004 ! mixture +[Term] +id: CHEBI:60924 +name: keratan sulfate +def: "A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide [3)-beta-Gal-(1->4)-beta-GlcNAc-(1->] and containing sulfo groups located at random positions." [] +synonym: "keratan sulfates" RELATED [] +synonym: "keratosulfate" RELATED [] +is_a: CHEBI:35722 ! sulfated glycosaminoglycan +is_a: CHEBI:37395 ! mucopolysaccharide +relationship: has_functional_parent CHEBI:29057 ! keratan + +[Term] +id: CHEBI:60980 +name: beta-glucoside +namespace: chebi_ontology +def: "A glucoside in which the anomeric carbon of the glycosidic bond is in a beta configuration" [] +subset: 3_STAR +synonym: "beta-glucosides" RELATED [ChEBI] +is_a: CHEBI:24278 ! glucoside + +[Term] +id: CHEBI:61015 +name: nephrotoxin +namespace: chebi_ontology +def: "A poison that interferes with the function of the kidneys." [] +subset: 3_STAR +synonym: "nephrotoxins" RELATED [ChEBI] +is_a: CHEBI:50909 ! nephrotoxic agent +is_a: CHEBI:64909 ! poison + +[Term] +id: CHEBI:61016 +name: angiotensin receptor antagonist +namespace: chebi_ontology +def: "A hormone antagonist that blocks angiotensin receptors." [] +subset: 3_STAR +synonym: "angiotensin receptor antagonists" RELATED [ChEBI] +is_a: CHEBI:49020 ! hormone antagonist + +[Term] +id: CHEBI:61049 +name: tacrolimus (anhydrous) +namespace: chebi_ontology +alt_id: CHEBI:42555 +alt_id: CHEBI:4958 +def: "A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis." [] +subset: 3_STAR +synonym: "(-)-FK 506" RELATED [ChemIDplus] +synonym: "(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone" EXACT IUPAC_NAME [IUPAC] +synonym: "8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN" RELATED [PDBeChem] +synonym: "FK 506" RELATED [KEGG_COMPOUND] +synonym: "FK506" RELATED [KEGG_COMPOUND] +synonym: "Prograf" RELATED BRAND_NAME [ChEBI] +synonym: "Tacrolimus" RELATED [KEGG_COMPOUND] +synonym: "tacrolimus" RELATED [ChemIDplus] +synonym: "tacrolimus" RELATED INN [KEGG_DRUG] +synonym: "tacrolimus anhydrous" RELATED [ChemIDplus] +xref: CAS:104987-11-3 {source="KEGG DRUG"} +xref: CAS:104987-11-3 {source="KEGG COMPOUND"} +xref: CAS:104987-11-3 {source="ChemIDplus"} +xref: DrugBank:DB00864 +xref: KEGG:C01375 +xref: KEGG:D08556 +xref: LIPID_MAPS_instance:LMPK04000003 {source="LIPID MAPS"} +xref: Patent:EP184162 +xref: Patent:US5665727 +xref: PDBeChem:FK5 +xref: Reaxys:3647477 {source="Reaxys"} +xref: Reaxys:8821611 {source="Reaxys"} +is_a: CHEBI:145565 ! macrolide lactam +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:76969 ! bacterial metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C44H69NO12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QJJXYPPXXYFBGM-LFZNUXCKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "804.01820" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "803.48198" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@@H]1C[C@@H](CC[C@H]1O)\\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)C\\C(C)=C\\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC" xsd:string + +[Term] +id: CHEBI:61057 +name: tacrolimus hydrate +namespace: chebi_ontology +def: "A hydrate that is the monohydrate form of tacrolimus." [] +subset: 3_STAR +synonym: "(-)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate" RELATED [ChemIDplus] +synonym: "(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone--water (1/1)" EXACT IUPAC_NAME [IUPAC] +synonym: "Prograf" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Protopic" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "tacrolimus" RELATED [ChemIDplus] +synonym: "tacrolimus monohydrate" RELATED [ChEBI] +synonym: "tsukubaenolide hydrate" RELATED [ChemIDplus] +xref: CAS:109581-93-3 {source="ChemIDplus"} +xref: CAS:109581-93-3 {source="KEGG DRUG"} +xref: DrugBank:DB00864 +xref: KEGG:D00107 +xref: Reaxys:6265275 {source="Reaxys"} +is_a: CHEBI:35505 ! hydrate +relationship: has_part CHEBI:61049 ! tacrolimus (anhydrous) +relationship: has_role CHEBI:35705 ! immunosuppressive agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C44H71NO13" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NWJQLQGQZSIBAF-MLAUYUEBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "822.03340" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "821.49254" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O.CO[C@@H]1C[C@@H](CC[C@H]1O)\\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)C\\C(C)=C\\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC" xsd:string + [Term] id: CHEBI:61115 name: EC 3.5.1.98 (histone deacetylase) inhibitor @@ -17954,6 +32621,7 @@ namespace: chebi_ontology def: "A compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [] subset: 3_STAR synonym: "sulfolipids" RELATED [ChEBI] +xref: Wikipedia:Sulfolipid is_a: CHEBI:18059 ! lipid is_a: CHEBI:25704 ! organic sulfate @@ -17980,6 +32648,39 @@ synonym: "fatty acid derivatives" RELATED [ChEBI] is_a: CHEBI:18059 ! lipid relationship: has_functional_parent CHEBI:35366 ! fatty acid +[Term] +id: CHEBI:61950 +name: microtubule-stabilising agent +namespace: chebi_ontology +def: "Any substance that interacts with tubulin to promote polymerisation of microtubules." [] +subset: 3_STAR +synonym: "microtubule stabilising agent" RELATED [ChEBI] +synonym: "microtubule stabilising role" RELATED [ChEBI] +synonym: "microtubule stabilizing agent" RELATED [ChEBI] +synonym: "microtubule stabilizing agents" RELATED [ChEBI] +synonym: "microtubule stabilizing role" RELATED [SUBMITTER] +synonym: "microtubule-stabilising agents" RELATED [ChEBI] +synonym: "microtubule-stabilizing agent" RELATED [ChEBI] +xref: PMID:11470606 {source="Europe PMC"} +is_a: CHEBI:60832 ! tubulin modulator + +[Term] +id: CHEBI:61951 +name: microtubule-destabilising agent +namespace: chebi_ontology +def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." [] +subset: 3_STAR +synonym: "microtubule destabilising agent" RELATED [ChEBI] +synonym: "microtubule destabilising agents" RELATED [ChEBI] +synonym: "microtubule destabilising role" RELATED [ChEBI] +synonym: "microtubule destabilizing role" RELATED [SUBMITTER] +synonym: "microtubule-destabilising agents" RELATED [ChEBI] +synonym: "microtubule-destabilizing agent" RELATED [ChEBI] +synonym: "microtubule-destabilizing agents" RELATED [ChEBI] +xref: PMID:17099073 {source="Europe PMC"} +is_a: CHEBI:60832 ! tubulin modulator +is_a: CHEBI:64911 ! antimitotic + [Term] id: CHEBI:62031 name: polar amino acid zwitterion @@ -17996,6 +32697,63 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(C([O-])=O)(*)[NH3+]" xsd:string +[Term] +id: CHEBI:62086 +name: metamizole(1-) +namespace: chebi_ontology +def: "An organosulfonate oxoanion resulting from the removal of a proton from the sulfonic acid group of metamizole." [] +subset: 3_STAR +synonym: "(antipyrinylmethylamino)methanesulfonate" RELATED [ChEBI] +synonym: "[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate" EXACT IUPAC_NAME [IUPAC] +synonym: "[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate" RELATED [ChEBI] +synonym: "metamizole anion" RELATED [ChEBI] +synonym: "N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulfonate" RELATED [ChEBI] +is_a: CHEBI:33554 ! organosulfonate oxoanion +relationship: is_conjugate_base_of CHEBI:62088 ! metamizole +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H16N3O4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LVWZTYCIRDMTEY-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "310.34900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.08670" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O" xsd:string + +[Term] +id: CHEBI:62088 +name: metamizole +namespace: chebi_ontology +def: "A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of causing risk of causing agranulocytosis." [] +subset: 3_STAR +synonym: "(antipyrinylmethylamino)methanesulfonic acid" RELATED [ChEBI] +synonym: "[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid" RELATED [ChEBI] +synonym: "metamizol" RELATED [ChemIDplus] +synonym: "metamizolum" RELATED [ChemIDplus] +synonym: "N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulfonic acid" RELATED [ChEBI] +xref: CAS:50567-35-6 {source="KEGG DRUG"} +xref: CAS:50567-35-6 {source="ChemIDplus"} +xref: Drug_Central:4659 {source="DrugCentral"} +xref: KEGG:D08188 +xref: LINCS:LSM-5839 +xref: Reaxys:327442 {source="Reaxys"} +is_a: CHEBI:26410 ! pyrazoles +is_a: CHEBI:37793 ! amino sulfonic acid +relationship: has_functional_parent CHEBI:31225 ! antipyrine +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35493 ! antipyretic +relationship: has_role CHEBI:49110 ! peripheral nervous system drug +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:73263 ! cyclooxygenase 3 inhibitor +relationship: is_conjugate_acid_of CHEBI:62086 ! metamizole(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C13H17N3O4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LVWZTYCIRDMTEY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "311.35700" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "311.09398" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(CS(O)(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O" xsd:string + [Term] id: CHEBI:62488 name: signalling molecule @@ -18009,6 +32767,19 @@ synonym: "signaling molecules" RELATED [ChEBI] synonym: "signalling molecules" RELATED [ChEBI] is_a: CHEBI:33280 ! molecular messenger +[Term] +id: CHEBI:62499 +name: methyl-branched fatty acid +namespace: chebi_ontology +def: "Any branched-chain fatty acid containing methyl branches only." [] +subset: 3_STAR +synonym: "methyl-branched fatty acids" RELATED [ChEBI] +xref: PMID:17030019 {source="Europe PMC"} +xref: PMID:19747846 {source="Europe PMC"} +xref: PMID:19933331 {source="SUBMITTER"} +is_a: CHEBI:35819 ! branched-chain fatty acid +relationship: is_conjugate_acid_of CHEBI:67013 ! methyl-branched fatty acid anion + [Term] id: CHEBI:62501 name: folate(2-) @@ -18045,7 +32816,6 @@ subset: 3_STAR synonym: "anionic phospholipids" RELATED [ChEBI] synonym: "phospholipid anion" RELATED [ChEBI] synonym: "phospholipid anions" RELATED [ChEBI] -is_a: CHEBI:18059 ! lipid is_a: CHEBI:58945 ! organophosphate oxoanion relationship: is_conjugate_base_of CHEBI:16247 ! phospholipid @@ -18059,6 +32829,16 @@ synonym: "aromatic esters" RELATED [ChEBI] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:35701 ! ester +[Term] +id: CHEBI:62733 +name: aromatic amide +namespace: chebi_ontology +def: "An amide in which the amide linkage is bonded directly to an aromatic system." [] +subset: 3_STAR +synonym: "aromatic amides" RELATED [ChEBI] +is_a: CHEBI:32988 ! amide +is_a: CHEBI:33659 ! organic aromatic compound + [Term] id: CHEBI:62761 name: tyrosine derivative @@ -18090,6 +32870,48 @@ synonym: "hepatoprotective agents" RELATED [ChEBI] synonym: "hepatoprotector" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent +[Term] +id: CHEBI:62872 +name: EC 1.2.3.1 (aldehyde oxidase) inhibitor +namespace: chebi_ontology +def: "An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1)." [] +subset: 3_STAR +synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitor" RELATED [ChEBI] +synonym: "aldehyde oxidase (EC 1.2.3.1) inhibitors" RELATED [ChEBI] +synonym: "aldehyde oxidase inhibitor" RELATED [ChEBI] +synonym: "aldehyde oxidase inhibitors" RELATED [ChEBI] +synonym: "aldehyde:oxygen oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "aldehyde:oxygen oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.2.3.1 (aldehyde oxidase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.2.3.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.2.3.1 inhibitors" RELATED [ChEBI] +synonym: "quinoline oxidase inhibitor" RELATED [ChEBI] +synonym: "quinoline oxidase inhibitors" RELATED [ChEBI] +synonym: "retinal oxidase inhibitor" RELATED [ChEBI] +synonym: "retinal oxidase inhibitors" RELATED [ChEBI] +synonym: "retinoic acid synthase inhibitor" RELATED [ChEBI] +synonym: "retinoic acid synthase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Aldehyde_oxidase +is_a: CHEBI:76853 ! EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor + +[Term] +id: CHEBI:62932 +name: mycophenolate +namespace: chebi_ontology +def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid." [] +subset: 3_STAR +synonym: "(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate" EXACT IUPAC_NAME [IUPAC] +synonym: "mycophenolate" EXACT [UniProt] +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:168396 ! mycophenolic acid +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H19O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/p-1/b9-4+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HPNSFSBZBAHARI-RUDMXATFSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "319.32920" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "319.11871" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC([O-])=O" xsd:string + [Term] id: CHEBI:62937 name: icosanoid anion @@ -18100,7 +32922,6 @@ synonym: "eicosanoid anion" RELATED [ChEBI] synonym: "eicosanoid anions" RELATED [ChEBI] synonym: "icosanoid anion" EXACT [ChEBI] synonym: "icosanoid anions" RELATED [ChEBI] -is_a: CHEBI:18059 ! lipid is_a: CHEBI:29067 ! carboxylic acid anion relationship: is_conjugate_base_of CHEBI:23899 ! icosanoid @@ -18156,6 +32977,36 @@ synonym: "1,3-thiazolium cations" RELATED [ChEBI] is_a: CHEBI:25697 ! organic cation is_a: CHEBI:38418 ! 1,3-thiazoles +[Term] +id: CHEBI:63070 +name: beta-alaninate +namespace: chebi_ontology +def: "A beta-amino-acid anion that is the conjugate base of beta-alanine." [] +subset: 3_STAR +synonym: "3-aminopropanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "beta-alaninate anion" RELATED [ChEBI] +synonym: "beta-alaninate(1-)" RELATED [ChEBI] +xref: Reaxys:3536336 {source="Reaxys"} +is_a: CHEBI:49095 ! beta-amino-acid anion +relationship: has_role CHEBI:78675 ! fundamental metabolite +relationship: is_conjugate_base_of CHEBI:16958 ! beta-alanine +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H6NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)/p-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UCMIRNVEIXFBKS-UHFFFAOYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "88.08520" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "88.04040" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCC([O-])=O" xsd:string + +[Term] +id: CHEBI:63161 +name: glycosyl compound +namespace: chebi_ontology +def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." [] +subset: 3_STAR +synonym: "glycosyl compounds" RELATED [ChEBI] +is_a: CHEBI:63299 ! carbohydrate derivative + [Term] id: CHEBI:63248 name: oxidising agent @@ -18187,6 +33038,46 @@ synonym: "derivatized carbohydrates" RELATED [ChEBI] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives relationship: has_functional_parent CHEBI:16646 ! carbohydrate +[Term] +id: CHEBI:63332 +name: EC 3.1.3.1 (alkaline phosphatase) inhibitor +namespace: chebi_ontology +def: "An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1)." [] +subset: 3_STAR +synonym: "alkaline phenyl phosphatase inhibitor" RELATED [ChEBI] +synonym: "alkaline phenyl phosphatase inhibitors" RELATED [ChEBI] +synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitor" RELATED [ChEBI] +synonym: "alkaline phosphatase (EC 3.1.3.1) inhibitors" RELATED [ChEBI] +synonym: "alkaline phosphatase inhibitor" RELATED [ChEBI] +synonym: "alkaline phosphatase inhibitors" RELATED [ChEBI] +synonym: "alkaline phosphohydrolase inhibitor" RELATED [ChEBI] +synonym: "alkaline phosphohydrolase inhibitors" RELATED [ChEBI] +synonym: "alkaline phosphomonoesterase inhibitor" RELATED [ChEBI] +synonym: "alkaline phosphomonoesterase inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.3.1 (alkaline phosphatase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.3.1 inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.3.1 inhibitors" RELATED [ChEBI] +synonym: "glycerophosphatase inhibitor" RELATED [ChEBI] +synonym: "glycerophosphatase inhibitors" RELATED [ChEBI] +synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [ChEBI] +synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [ChEBI] +synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitor" RELATED [ChEBI] +synonym: "phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors" RELATED [ChEBI] +synonym: "phosphomonoesterase inhibitor" RELATED [ChEBI] +synonym: "phosphomonoesterase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Alkaline_phosphatase +is_a: CHEBI:76775 ! EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor + +[Term] +id: CHEBI:63367 +name: monosaccharide derivative +namespace: chebi_ontology +def: "A carbohydrate derivative that is formally obtained from a monosaccharide." [] +subset: 3_STAR +synonym: "monosaccharide derivatives" RELATED [ChEBI] +is_a: CHEBI:63299 ! carbohydrate derivative +relationship: has_functional_parent CHEBI:35381 ! monosaccharide + [Term] id: CHEBI:63436 name: carbohydrate acid derivative @@ -18261,6 +33152,267 @@ is_a: CHEBI:29067 ! carboxylic acid anion relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative +[Term] +id: CHEBI:63580 +name: ribavirin +namespace: chebi_ontology +alt_id: CHEBI:8840 +def: "A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses." [] +subset: 3_STAR +synonym: "1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide" RELATED [ChemIDplus] +synonym: "1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide" RELATED [ChemIDplus] +synonym: "RBV" RELATED [DrugBank] +synonym: "ribavirin" RELATED INN [KEGG_DRUG] +synonym: "ribavirina" RELATED INN [DrugBank] +synonym: "ribavirine" RELATED INN [DrugBank] +synonym: "ribavirinum" RELATED INN [DrugBank] +xref: Beilstein:892462 {source="ChemIDplus"} +xref: CAS:36791-04-5 {source="ChemIDplus"} +xref: CAS:36791-04-5 {source="KEGG DRUG"} +xref: Drug_Central:2373 {source="DrugCentral"} +xref: DrugBank:DB00811 +xref: KEGG:D00423 +xref: LINCS:LSM-5701 +xref: PMID:21827730 {source="Europe PMC"} +xref: PMID:22052088 {source="Europe PMC"} +xref: PMID:22052220 {source="Europe PMC"} +xref: PMID:22156853 {source="Europe PMC"} +xref: PMID:22158703 {source="Europe PMC"} +xref: PMID:22212566 {source="Europe PMC"} +xref: PMID:22212568 {source="Europe PMC"} +xref: PMID:22212569 {source="Europe PMC"} +xref: PMID:22212572 {source="Europe PMC"} +xref: PMID:22212576 {source="Europe PMC"} +xref: PMID:22212579 {source="Europe PMC"} +xref: PMID:22220723 {source="Europe PMC"} +xref: PMID:22239498 {source="Europe PMC"} +xref: PMID:22239511 {source="Europe PMC"} +xref: PMID:29438107 {source="Europe PMC"} +xref: Reaxys:892462 {source="Reaxys"} +xref: Wikipedia:Ribavirin +is_a: CHEBI:140324 ! primary carboxamide +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:62733 ! aromatic amide +is_a: CHEBI:63594 ! 1-ribosyltriazole +relationship: has_functional_parent CHEBI:180482 ! 1,2,4-triazole-3-carboxamide +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:35441 ! antiinfective agent +relationship: has_role CHEBI:59897 ! EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H12N4O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "IWUCXVSUMQZMFG-AFCXAGJDSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "244.20470" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "244.08077" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O" xsd:string + +[Term] +id: CHEBI:63581 +name: stavudine +namespace: chebi_ontology +alt_id: CHEBI:9253 +def: "A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase" [] +subset: 3_STAR +synonym: "1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine" RELATED [ChemIDplus] +synonym: "1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "2',3'-Didehydro-3'-deoxythimidine" RELATED [KEGG_COMPOUND] +synonym: "3'-Deoxy-2'-thymidinene" RELATED [DrugBank] +synonym: "d4T" RELATED [KEGG_COMPOUND] +synonym: "estavudina" RELATED INN [DrugBank] +synonym: "Sanilvudine" RELATED [KEGG_COMPOUND] +synonym: "Stavudine" EXACT [KEGG_COMPOUND] +synonym: "stavudine" RELATED INN [KEGG_DRUG] +synonym: "stavudinum" RELATED INN [DrugBank] +synonym: "STV" RELATED [DrugBank] +xref: CAS:3056-17-5 {source="KEGG COMPOUND"} +xref: CAS:3056-17-5 {source="ChemIDplus"} +xref: Drug_Central:2478 {source="DrugCentral"} +xref: DrugBank:DB00649 +xref: KEGG:C07312 +xref: KEGG:D00445 +xref: LINCS:LSM-5983 +xref: Patent:EP334368 +xref: Patent:US5130421 +xref: Reaxys:618327 {source="Reaxys"} +xref: Wikipedia:Stavudine +is_a: CHEBI:51659 ! dihydrofuran +is_a: CHEBI:60783 ! nucleoside analogue +relationship: has_functional_parent CHEBI:17821 ! thymine +relationship: has_role CHEBI:35221 ! antimetabolite +relationship: has_role CHEBI:59897 ! EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H12N2O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2-4,7-8,13H,5H2,1H3,(H,11,14,15)/t7-,8+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XNKLLVCARDGLGL-JGVFFNPUSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "224.21330" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "224.07971" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1cn([C@@H]2O[C@H](CO)C=C2)c(=O)[nH]c1=O" xsd:string + +[Term] +id: CHEBI:63593 +name: 1-glycosyltriazole +namespace: chebi_ontology +def: "An N-glycosyl compound that consists of any triazole having a glycosyl residue attached at position 1." [] +subset: 3_STAR +synonym: "1-glycosyltriazoles" RELATED [ChEBI] +is_a: CHEBI:21731 ! N-glycosyl compound +is_a: CHEBI:35727 ! triazoles + +[Term] +id: CHEBI:63594 +name: 1-ribosyltriazole +namespace: chebi_ontology +def: "A 1-glycosyltriazole in which the glycosyl residue is specified as ribosyl." [] +subset: 3_STAR +synonym: "1-ribosyltriazoles" RELATED [ChEBI] +is_a: CHEBI:63593 ! 1-glycosyltriazole + +[Term] +id: CHEBI:63622 +name: sotalol +namespace: chebi_ontology +alt_id: CHEBI:9206 +def: "A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias." [] +subset: 3_STAR +synonym: "4'-(1-hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide" RELATED [ChemIDplus] +synonym: "beta-cardone" RELATED [ChemIDplus] +synonym: "N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Sotalol" EXACT [KEGG_COMPOUND] +synonym: "sotalol" RELATED INN [ChemIDplus] +synonym: "sotalolum" RELATED INN [ChemIDplus] +xref: CAS:3930-20-9 {source="KEGG COMPOUND"} +xref: CAS:3930-20-9 {source="ChemIDplus"} +xref: Drug_Central:2464 {source="DrugCentral"} +xref: DrugBank:DB00489 +xref: HMDB:HMDB0014632 +xref: KEGG:C07309 +xref: KEGG:D08525 +xref: LINCS:LSM-1465 +xref: PMID:20562595 {source="Europe PMC"} +xref: PMID:21553267 {source="Europe PMC"} +xref: PMID:21854895 {source="Europe PMC"} +xref: Reaxys:2380820 {source="Reaxys"} +xref: Wikipedia:Sotalol +is_a: CHEBI:23981 ! ethanolamines +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:35681 ! secondary alcohol +is_a: CHEBI:50995 ! secondary amino compound +relationship: has_role CHEBI:35530 ! beta-adrenergic antagonist +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:38070 ! anti-arrhythmia drug +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_base_of CHEBI:63647 ! sotalol(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H20N2O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZBMZVLHSJCTVON-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "272.36400" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "272.11946" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1" xsd:string + +[Term] +id: CHEBI:63625 +name: tenofovir (anhydrous) +namespace: chebi_ontology +def: "A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection." [] +subset: 3_STAR +synonym: "(R)-PMPA" RELATED [ChEBI] +synonym: "({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "anh. tenofovir" RELATED [ChEBI] +synonym: "anhydrous tenofovir" RELATED [ChEBI] +synonym: "tenofovir" RELATED INN [ChemIDplus] +synonym: "tenofovir (anh.)" RELATED [ChEBI] +xref: CAS:147127-20-6 {source="ChemIDplus"} +xref: DrugBank:DB00300 +xref: HMDB:HMDB0014445 +xref: KEGG:D06074 +xref: LINCS:LSM-5340 +xref: PMID:11777298 {source="Europe PMC"} +xref: PMID:25017682 {source="Europe PMC"} +xref: PMID:28166217 {source="Europe PMC"} +xref: PMID:28503983 {source="Europe PMC"} +xref: Reaxys:7415378 {source="Reaxys"} +xref: Wikipedia:Tenofovir +is_a: CHEBI:26069 ! phosphonic acids +is_a: CHEBI:60783 ! nucleoside analogue +relationship: has_role CHEBI:36044 ! antiviral drug +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:53756 ! HIV-1 reverse transcriptase inhibitor +relationship: is_conjugate_acid_of CHEBI:134504 ! tenofovir(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H14N5O4P" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SGOIRFVFHAKUTI-ZCFIWIBFSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "287.21230" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "287.07834" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O" xsd:string + +[Term] +id: CHEBI:63647 +name: sotalol(1+) +namespace: chebi_ontology +def: "An ammonium ion resulting from the protonation of the nitrogen of the secondary amino group of sotalol." [] +subset: 3_STAR +synonym: "N-(2-hydroxy-2-{4-[(methylsulfonyl)amino]phenyl}ethyl)propan-2-aminium" EXACT IUPAC_NAME [IUPAC] +xref: Reaxys:6417063 {source="Reaxys"} +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:63622 ! sotalol +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H21N2O3S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZBMZVLHSJCTVON-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "273.37200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "273.12674" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)[NH2+]CC(O)c1ccc(NS(C)(=O)=O)cc1" xsd:string + +[Term] +id: CHEBI:6367 +name: lamotrigine +namespace: chebi_ontology +def: "A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6." [] +subset: 3_STAR +synonym: "3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine" RELATED [ChemIDplus] +synonym: "6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine" EXACT IUPAC_NAME [IUPAC] +synonym: "Lamictal" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "lamotrigina" RELATED INN [ChemIDplus] +synonym: "lamotrigine" RELATED INN [ChemIDplus] +synonym: "lamotriginum" RELATED INN [ChemIDplus] +xref: CAS:84057-84-1 {source="ChemIDplus"} +xref: CAS:84057-84-1 {source="NIST Chemistry WebBook"} +xref: CAS:84057-84-1 {source="KEGG DRUG"} +xref: Drug_Central:1540 {source="DrugCentral"} +xref: DrugBank:DB00555 +xref: HMDB:HMDB0014695 +xref: KEGG:D00354 +xref: LINCS:LSM-4104 +xref: PMID:19430925 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: PMID:21242744 {source="Europe PMC"} +xref: Reaxys:7589268 {source="Reaxys"} +xref: Wikipedia:Lamotrigine +is_a: CHEBI:23697 ! dichlorobenzene +is_a: CHEBI:39410 ! 1,2,4-triazines +is_a: CHEBI:50471 ! primary arylamine +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35469 ! antidepressant +relationship: has_role CHEBI:35477 ! antimanic drug +relationship: has_role CHEBI:35481 ! non-narcotic analgesic +relationship: has_role CHEBI:35623 ! anticonvulsant +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:38215 ! calcium channel blocker +relationship: has_role CHEBI:60798 ! excitatory amino acid antagonist +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H7Cl2N5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PYZRQGJRPPTADH-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "256.09100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "255.00785" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl" xsd:string + [Term] id: CHEBI:63726 name: neuroprotective agent @@ -18272,6 +33424,17 @@ synonym: "neuroprotectants" RELATED [ChEBI] synonym: "neuroprotective agents" RELATED [ChEBI] is_a: CHEBI:50267 ! protective agent +[Term] +id: CHEBI:63944 +name: macrocyclic lactone +namespace: chebi_ontology +alt_id: CHEBI:50333 +def: "Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule." [] +subset: 3_STAR +synonym: "macrocyclic lactones" RELATED [ChEBI] +is_a: CHEBI:25000 ! lactone +is_a: CHEBI:51026 ! macrocycle + [Term] id: CHEBI:64018 name: protein kinase C agonist @@ -18281,6 +33444,59 @@ subset: 3_STAR synonym: "protein kinase C agonists" RELATED [ChEBI] is_a: CHEBI:64106 ! protein kinase agonist +[Term] +id: CHEBI:64045 +name: amisulpride +namespace: chebi_ontology +def: "A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects." [] +subset: 3_STAR +synonym: "4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide" RELATED [ChemIDplus] +synonym: "4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide" RELATED [ChemIDplus] +synonym: "4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Aminosultopride" RELATED [DrugBank] +synonym: "amisulprida" RELATED INN [ChemIDplus] +synonym: "amisulpride" RELATED INN [KEGG_DRUG] +synonym: "amisulpridum" RELATED INN [ChemIDplus] +xref: CAS:71675-85-9 {source="ChemIDplus"} +xref: Drug_Central:179 {source="DrugCentral"} +xref: DrugBank:DB06288 +xref: HMDB:HMDB0015633 +xref: KEGG:D07310 +xref: LINCS:LSM-1669 +xref: Patent:BE872585 +xref: Patent:US4401822 +xref: PMID:21176108 {source="Europe PMC"} +xref: PMID:21647545 {source="Europe PMC"} +xref: PMID:21663752 {source="Europe PMC"} +xref: PMID:21746752 {source="Europe PMC"} +xref: PMID:21822161 {source="Europe PMC"} +xref: PMID:21845006 {source="Europe PMC"} +xref: PMID:21852060 {source="Europe PMC"} +xref: PMID:21886905 {source="Europe PMC"} +xref: PMID:21888613 {source="Europe PMC"} +xref: PMID:21969105 {source="Europe PMC"} +xref: PMID:22035899 {source="Europe PMC"} +xref: PMID:22059694 {source="Europe PMC"} +xref: PMID:22121864 {source="Europe PMC"} +xref: PMID:22241281 {source="Europe PMC"} +xref: PMID:22250612 {source="Europe PMC"} +xref: Reaxys:6876191 {source="Reaxys"} +xref: Wikipedia:Amisulpride +is_a: CHEBI:22702 ! benzamides +is_a: CHEBI:33860 ! aromatic amine +is_a: CHEBI:35850 ! sulfone +is_a: CHEBI:38260 ! pyrrolidines +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:65191 ! second generation antipsychotic +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H27N3O4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NTJOBXMMWNYJFB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "369.47900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "369.17223" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC" xsd:string + [Term] id: CHEBI:64047 name: food additive @@ -18324,6 +33540,36 @@ subset: 3_STAR synonym: "aralkylamino compounds" RELATED [ChEBI] is_a: CHEBI:50047 ! organic amino compound +[Term] +id: CHEBI:64370 +name: glutamate transporter activator +namespace: chebi_ontology +def: "A neurotransmitter transporter modulator that activates glutamate transporters." [] +subset: 3_STAR +synonym: "excitatory amino-acid transporter activator" RELATED [ChEBI] +synonym: "excitatory amino-acid transporter activators" RELATED [ChEBI] +synonym: "glutamate transporter activators" RELATED [ChEBI] +is_a: CHEBI:64371 ! neurotransmitter transporter modulator + +[Term] +id: CHEBI:64371 +name: neurotransmitter transporter modulator +namespace: chebi_ontology +def: "A membrane transport modulator that affects the transport of neurotransmitters." [] +subset: 3_STAR +synonym: "neurotransmitter transporter modulators" RELATED [ChEBI] +is_a: CHEBI:35942 ! neurotransmitter agent +is_a: CHEBI:38632 ! membrane transport modulator + +[Term] +id: CHEBI:64459 +name: biaryl +namespace: chebi_ontology +def: "An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond." [] +subset: 3_STAR +synonym: "biaryls" RELATED [ChEBI] +is_a: CHEBI:33659 ! organic aromatic compound + [Term] id: CHEBI:64570 name: EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor @@ -18477,6 +33723,17 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "1637.87800" xsd:strin property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1636.71666" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N" xsd:string +[Term] +id: CHEBI:64678 +name: anthracycline cation +namespace: chebi_ontology +def: "An organic cation obtained by protonation of any anthracycline." [] +subset: 3_STAR +synonym: "anthracycline cations" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:48120 ! anthracycline + [Term] id: CHEBI:64708 name: one-carbon compound @@ -18495,6 +33752,26 @@ subset: 3_STAR synonym: "organic acids" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity +[Term] +id: CHEBI:64816 +name: doxorubicin(1+) +namespace: chebi_ontology +def: "An anthracycline cation that is the conjugate acid of doxorubicin, arising from protonation of the amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-azaniumyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside" EXACT IUPAC_NAME [IUPAC] +synonym: "doxorubicin" RELATED [UniProt] +synonym: "doxorubicin cation" RELATED [ChEBI] +xref: Reaxys:5898339 {source="Reaxys"} +is_a: CHEBI:64678 ! anthracycline cation +relationship: is_conjugate_acid_of CHEBI:28748 ! doxorubicin +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C27H30NO11" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/p+1/t10-,13-,15-,17-,22+,27-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "AOJJSUZBOXZQNB-TZSSRYMLSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "544.52720" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "544.18134" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H]([NH3+])[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO" xsd:string + [Term] id: CHEBI:64857 name: cosmetic @@ -18524,6 +33801,83 @@ synonym: "toxic substances" RELATED [ChEBI] xref: Wikipedia:Poison is_a: CHEBI:24432 ! biological role +[Term] +id: CHEBI:64911 +name: antimitotic +namespace: chebi_ontology +def: "Any compound that inhibits cell division (mitosis)." [] +subset: 3_STAR +synonym: "antimitotics" RELATED [ChEBI] +synonym: "mitosis inhibitor" RELATED [ChEBI] +synonym: "mitosis inhibitors" RELATED [ChEBI] +synonym: "mitotic inhibitor" RELATED [ChEBI] +synonym: "mitotic inhibitors" RELATED [ChEBI] +xref: Wikipedia:Mitotic_inhibitor +is_a: CHEBI:52210 ! pharmacological role + +[Term] +id: CHEBI:64912 +name: antimycobacterial drug +namespace: chebi_ontology +def: "A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy." [] +subset: 3_STAR +synonym: "antimycobacterial agent" RELATED [ChEBI] +synonym: "antimycobacterial agents" RELATED [ChEBI] +synonym: "antimycobacterial drugs" RELATED [ChEBI] +synonym: "antimycobacterials" RELATED [ChEBI] +synonym: "antimycobacterium" RELATED [ChEBI] +is_a: CHEBI:36047 ! antibacterial drug + +[Term] +id: CHEBI:64915 +name: antiplasmodial drug +namespace: chebi_ontology +def: "An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria." [] +subset: 3_STAR +synonym: "antiplasmodial agent" RELATED [ChEBI] +synonym: "antiplasmodial agents" RELATED [ChEBI] +synonym: "antiplasmodial drugs" RELATED [ChEBI] +synonym: "antiplasmodium agent" RELATED [ChEBI] +synonym: "antiplasmodium agents" RELATED [ChEBI] +synonym: "antiplasmodium drug" RELATED [ChEBI] +synonym: "antiplasmodium drugs" RELATED [ChEBI] +is_a: CHEBI:35820 ! antiprotozoal drug + +[Term] +id: CHEBI:64926 +name: serine protease inhibitor +namespace: chebi_ontology +def: "Any protease inhibitor that restricts the action of a serine protease." [] +subset: 3_STAR +synonym: "serine protease inhibitors" RELATED [ChEBI] +synonym: "serine proteinase inhibitor" RELATED [ChEBI] +synonym: "serine proteinase inhibitors" RELATED [ChEBI] +is_a: CHEBI:37670 ! protease inhibitor + +[Term] +id: CHEBI:64946 +name: anti-HIV agent +namespace: chebi_ontology +def: "An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus." [] +subset: 3_STAR +synonym: "anti-AIDS agent" RELATED [ChEBI] +synonym: "anti-AIDS agents" RELATED [ChEBI] +synonym: "anti-HIV agents" RELATED [ChEBI] +is_a: CHEBI:22587 ! antiviral agent + +[Term] +id: CHEBI:64947 +name: anti-HIV-1 agent +namespace: chebi_ontology +def: "An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus." [] +subset: 3_STAR +synonym: "anti-HIV-1 agents" RELATED [ChEBI] +synonym: "anti-HTLV-III agent" RELATED [ChEBI] +synonym: "anti-HTLV-III agents" RELATED [ChEBI] +synonym: "anti-LAV agent" RELATED [ChEBI] +synonym: "anti-LAV agents" RELATED [ChEBI] +is_a: CHEBI:64946 ! anti-HIV agent + [Term] id: CHEBI:6495 name: lipoprotein @@ -18539,6 +33893,144 @@ is_a: CHEBI:39024 ! clathrate compound relationship: has_part CHEBI:39015 ! apolipoprotein relationship: has_role CHEBI:76971 ! Escherichia coli metabolite +[Term] +id: CHEBI:64964 +name: EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor +namespace: chebi_ontology +def: "A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34)." [] +subset: 3_STAR +synonym: "5-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "5-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "5-LOX inhibitor" RELATED [ChEBI] +synonym: "5-LOX inhibitors" RELATED [ChEBI] +synonym: "5delta-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "5delta-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitor" RELATED [ChEBI] +synonym: "arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors" RELATED [ChEBI] +synonym: "arachidonate 5-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "arachidonate 5-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "arachidonic 5-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "arachidonic 5-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "arachidonic acid 5-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "arachidonic acid 5-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "C-5-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "C-5-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "delta(5)-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "delta(5)-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.34 inhibitor" RELATED [ChEBI] +synonym: "EC 1.13.11.34 inhibitors" RELATED [ChEBI] +synonym: "leukotriene A4 synthase inhibitor" RELATED [ChEBI] +synonym: "leukotriene A4 synthase inhibitors" RELATED [ChEBI] +synonym: "leukotriene-A4 synthase inhibitor" RELATED [ChEBI] +synonym: "leukotriene-A4 synthase inhibitors" RELATED [ChEBI] +synonym: "LTA synthase inhibitor" RELATED [ChEBI] +synonym: "LTA synthase inhibitors" RELATED [ChEBI] +is_a: CHEBI:35856 ! lipoxygenase inhibitor + +[Term] +id: CHEBI:64996 +name: EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor +namespace: chebi_ontology +def: "A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33)." [] +subset: 3_STAR +synonym: "15-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "15-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "15-LOX inhibitor" RELATED [ChEBI] +synonym: "15-LOX inhibitors" RELATED [ChEBI] +synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor" RELATED [ChEBI] +synonym: "arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitors" RELATED [ChEBI] +synonym: "arachidonate 15-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "arachidonate 15-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "arachidonate:oxygen 15-oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "arachidonate:oxygen 15-oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.33 inhibitor" RELATED [ChEBI] +synonym: "EC 1.13.11.33 inhibitors" RELATED [ChEBI] +synonym: "linoleic acid omega(6)-lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "linoleic acid omega(6)-lipoxygenase inhibitors" RELATED [ChEBI] +synonym: "omega(6) lipoxygenase inhibitor" RELATED [ChEBI] +synonym: "omega(6) lipoxygenase inhibitors" RELATED [ChEBI] +xref: Wikipedia:ALOX15 +is_a: CHEBI:35856 ! lipoxygenase inhibitor + +[Term] +id: CHEBI:65001 +name: EC 3.1.1.3 (triacylglycerol lipase) inhibitor +namespace: chebi_ontology +def: "Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3)." [] +subset: 3_STAR +synonym: "butyrinase inhibitor" RELATED [ChEBI] +synonym: "butyrinase inhibitors" RELATED [ChEBI] +synonym: "cacordase inhibitor" RELATED [ChEBI] +synonym: "cacordase inhibitors" RELATED [ChEBI] +synonym: "capalase L inhibitor" RELATED [ChEBI] +synonym: "capalase L inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.1.3 (triacylglycerol lipase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.1.3 inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.1.3 inhibitors" RELATED [ChEBI] +synonym: "GEH inhibitor" RELATED [ChEBI] +synonym: "GEH inhibitors" RELATED [ChEBI] +synonym: "glycerol ester hydrolase inhibitor" RELATED [ChEBI] +synonym: "glycerol ester hydrolase inhibitors" RELATED [ChEBI] +synonym: "glycerol-ester hydrolase inhibitor" RELATED [ChEBI] +synonym: "glycerol-ester hydrolase inhibitors" RELATED [ChEBI] +synonym: "heparin releasable hepatic lipase inhibitor" RELATED [ChEBI] +synonym: "heparin releasable hepatic lipase inhibitors" RELATED [ChEBI] +synonym: "hepatic lipase inhibitor" RELATED [ChEBI] +synonym: "hepatic lipase inhibitors" RELATED [ChEBI] +synonym: "hepatic monoacylglycerol acyltransferase inhibitor" RELATED [ChEBI] +synonym: "hepatic monoacylglycerol acyltransferase inhibitors" RELATED [ChEBI] +synonym: "lipase inhibitor" RELATED [ChEBI] +synonym: "lipase inhibitors" RELATED [ChEBI] +synonym: "lipazin inhibitor" RELATED [ChEBI] +synonym: "lipazin inhibitors" RELATED [ChEBI] +synonym: "liver lipase inhibitor" RELATED [ChEBI] +synonym: "liver lipase inhibitors" RELATED [ChEBI] +synonym: "pancreatic lipase inhibitor" RELATED [ChEBI] +synonym: "pancreatic lipase inhibitors" RELATED [ChEBI] +synonym: "pancreatic triacylglycerol lipase inhibitor" RELATED [ChEBI] +synonym: "pancreatic triacylglycerol lipase inhibitors" RELATED [ChEBI] +synonym: "post-heparin plasma protamine-resistant lipase inhibitor" RELATED [ChEBI] +synonym: "post-heparin plasma protamine-resistant lipase inhibitors" RELATED [ChEBI] +synonym: "PPL inhibitor" RELATED [ChEBI] +synonym: "PPL inhibitors" RELATED [ChEBI] +synonym: "salt-resistant post-heparin lipase inhibitor" RELATED [ChEBI] +synonym: "salt-resistant post-heparin lipase inhibitors" RELATED [ChEBI] +synonym: "steapsin inhibitor" RELATED [ChEBI] +synonym: "steapsin inhibitors" RELATED [ChEBI] +synonym: "triacetinase inhibitor" RELATED [ChEBI] +synonym: "triacetinase inhibitors" RELATED [ChEBI] +synonym: "triacylglycerol ester hydrolase inhibitor" RELATED [ChEBI] +synonym: "triacylglycerol ester hydrolase inhibitors" RELATED [ChEBI] +synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitor" RELATED [ChEBI] +synonym: "triacylglycerol lipase (EC 3.1.1.3) inhibitors" RELATED [ChEBI] +synonym: "triacylglycerol lipase inhibitor" RELATED [ChEBI] +synonym: "triacylglycerol lipase inhibitors" RELATED [ChEBI] +synonym: "tributyrase inhibitor" RELATED [ChEBI] +synonym: "tributyrase inhibitors" RELATED [ChEBI] +synonym: "tributyrin esterase inhibitor" RELATED [ChEBI] +synonym: "tributyrin esterase inhibitors" RELATED [ChEBI] +synonym: "tributyrinase inhibitor" RELATED [ChEBI] +synonym: "tributyrinase inhibitors" RELATED [ChEBI] +synonym: "triglyceridase inhibitor" RELATED [ChEBI] +synonym: "triglyceridase inhibitors" RELATED [ChEBI] +synonym: "triglyceride hydrolase inhibitor" RELATED [ChEBI] +synonym: "triglyceride hydrolase inhibitors" RELATED [ChEBI] +synonym: "triglyceride lipase inhibitor" RELATED [ChEBI] +synonym: "triglyceride lipase inhibitors" RELATED [ChEBI] +synonym: "triolein hydrolase inhibitor" RELATED [ChEBI] +synonym: "triolein hydrolase inhibitors" RELATED [ChEBI] +synonym: "Tween hydrolase inhibitor" RELATED [ChEBI] +synonym: "Tween hydrolase inhibitors" RELATED [ChEBI] +synonym: "tween-hydrolysing esterase inhibitor" RELATED [ChEBI] +synonym: "tween-hydrolyzing esterase inhibitors" RELATED [ChEBI] +synonym: "Tweenase inhibitor" RELATED [ChEBI] +synonym: "Tweenase inhibitors" RELATED [ChEBI] +synonym: "Tweenesterase inhibitor" RELATED [ChEBI] +synonym: "Tweenesterase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76773 ! EC 3.1.1.* (carboxylic ester hydrolase) inhibitor + [Term] id: CHEBI:65023 name: anti-asthmatic agent @@ -18550,6 +34042,165 @@ synonym: "antiasthmatic agent" RELATED [ChEBI] synonym: "antiasthmatic agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application +[Term] +id: CHEBI:65172 +name: ximelagatran +namespace: chebi_ontology +def: "A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted into the corresponding amidoxime. A prodrug for melagatran, ximelagatran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage." [] +subset: 3_STAR +synonym: "ethyl 2-[[(1R)-1-cyclohexyl-2- [(2S)-2-[[4-(N'-hydroxycarbamimidoyl) phenyl]methylcarbamoyl]azetidin-1-yl]- 2-oxo-ethyl]amino]acetate" RELATED [ChEBI] +synonym: "ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate" EXACT IUPAC_NAME [IUPAC] +synonym: "Exanta" RELATED [SUBMITTER] +synonym: "Exarta" RELATED [SUBMITTER] +synonym: "H 376-95" RELATED [ChemIDplus] +synonym: "H 376/95" RELATED [ChemIDplus] +synonym: "H 37695" RELATED [ChemIDplus] +synonym: "ximelagatran" RELATED INN [WHO_MedNet] +synonym: "ximelagatran (oxime form)" RELATED [ChEBI] +synonym: "ximelagatranum" RELATED INN [WHO_MedNet] +xref: CAS:192939-46-1 {source="KEGG DRUG"} +xref: CAS:192939-46-1 {source="ChemIDplus"} +xref: Drug_Central:2852 {source="DrugCentral"} +xref: DrugBank:DB04898 {source="SUBMITTER"} +xref: KEGG:D01981 {source="SUBMITTER"} +xref: PMID:12846595 {source="Europe PMC"} +xref: PMID:15487959 {source="Europe PMC"} +xref: PMID:16084146 {source="Europe PMC"} +xref: PMID:16106594 {source="Europe PMC"} +xref: PMID:16123912 {source="Europe PMC"} +xref: PMID:16511607 {source="Europe PMC"} +xref: PMID:16767816 {source="Europe PMC"} +xref: PMID:17319469 {source="Europe PMC"} +xref: PMID:17636192 {source="Europe PMC"} +xref: PMID:19028773 {source="Europe PMC"} +xref: PMID:20020269 {source="Europe PMC"} +xref: PMID:28338626 {source="Europe PMC"} +xref: Reaxys:14559655 {source="Reaxys"} +xref: Wikipedia:Ximelagatran +is_a: CHEBI:140325 ! secondary carboxamide +is_a: CHEBI:140326 ! tertiary carboxamide +is_a: CHEBI:23990 ! ethyl ester +is_a: CHEBI:38777 ! azetidines +is_a: CHEBI:50995 ! secondary amino compound +is_a: CHEBI:65234 ! amidoxime +relationship: has_functional_parent CHEBI:43966 ! melagatran +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:64926 ! serine protease inhibitor +relationship: has_role CHEBI:65232 ! EC 3.4.21.5 (thrombin) inhibitor +relationship: is_tautomer_of CHEBI:136702 ! ximelagatran (hydroxylamine form) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H35N5O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H35N5O5/c1-2-34-20(30)15-26-21(17-6-4-3-5-7-17)24(32)29-13-12-19(29)23(31)27-14-16-8-10-18(11-9-16)22(25)28-33/h8-11,17,19,21,26,33H,2-7,12-15H2,1H3,(H2,25,28)(H,27,31)/t19-,21+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "ZXIBCJHYVWYIKI-PZJWPPBQSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "473.56520" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "473.26382" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]1(CCN1C(=O)[C@H](NCC(=O)OCC)C1CCCCC1)C(=O)NCc1ccc(cc1)C(N)=NO" xsd:string + +[Term] +id: CHEBI:65173 +name: iloperidone +namespace: chebi_ontology +def: "A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia." [] +subset: 3_STAR +synonym: "1-(4-{3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethanone" EXACT IUPAC_NAME [IUPAC] +synonym: "1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone" RELATED [ChEBI] +synonym: "4'-(3-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone" RELATED [ChemIDplus] +synonym: "Fanapt" RELATED BRAND_NAME [SUBMITTER] +synonym: "Fanapta" RELATED BRAND_NAME [SUBMITTER] +synonym: "iloperidona" RELATED INN [WHO_MedNet] +synonym: "iloperidone" RELATED INN [WHO_MedNet] +synonym: "iloperidonum" RELATED INN [WHO_MedNet] +synonym: "Zomaril" RELATED BRAND_NAME [SUBMITTER] +xref: CAS:133454-47-4 {source="SUBMITTER"} +xref: CAS:133454-47-4 {source="ChemIDplus"} +xref: Drug_Central:3294 {source="DrugCentral"} +xref: KEGG:D02666 {source="SUBMITTER"} +xref: LINCS:LSM-5598 +xref: PMID:21289324 {source="Europe PMC"} +xref: PMID:21474903 {source="Europe PMC"} +xref: PMID:21600386 {source="Europe PMC"} +xref: PMID:22161738 {source="Europe PMC"} +xref: PMID:22217439 {source="Europe PMC"} +xref: PMID:22453868 {source="Europe PMC"} +xref: PMID:22465688 {source="Europe PMC"} +xref: PMID:22617084 {source="Europe PMC"} +xref: Reaxys:7233425 {source="Reaxys"} +xref: Wikipedia:Iloperidone +is_a: CHEBI:26151 ! piperidines +is_a: CHEBI:35618 ! aromatic ether +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:50996 ! tertiary amino compound +is_a: CHEBI:51545 ! 1,2-benzoxazoles +is_a: CHEBI:51867 ! methyl ketone +is_a: CHEBI:63534 ! monoamine +is_a: CHEBI:76224 ! aromatic ketone +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:65191 ! second generation antipsychotic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H27FN2O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XMXHEBAFVSFQEX-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "426.48060" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.19549" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O" xsd:string + +[Term] +id: CHEBI:65190 +name: first generation antipsychotic +namespace: chebi_ontology +def: "Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased." [] +subset: 3_STAR +synonym: "first generation antipsychotic agent" RELATED [ChEBI] +synonym: "first generation antipsychotic agents" RELATED [ChEBI] +synonym: "first generation antipsychotic drug" RELATED [ChEBI] +synonym: "first generation antipsychotic drugs" RELATED [ChEBI] +synonym: "first generation antipsychotics" RELATED [ChEBI] +synonym: "typical antipsychotic" RELATED [ChEBI] +synonym: "typical antipsychotic agent" RELATED [ChEBI] +synonym: "typical antipsychotic agents" RELATED [ChEBI] +synonym: "typical antipsychotic drug" RELATED [ChEBI] +synonym: "typical antipsychotic drugs" RELATED [ChEBI] +synonym: "typical antipsychotics" RELATED [ChEBI] +xref: Wikipedia:Typical_antipsychotic +is_a: CHEBI:35476 ! antipsychotic agent + +[Term] +id: CHEBI:65191 +name: second generation antipsychotic +namespace: chebi_ontology +def: "Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements." [] +subset: 3_STAR +synonym: "atypical antipsychotic" RELATED [ChEBI] +synonym: "atypical antipsychotic agent" RELATED [ChEBI] +synonym: "atypical antipsychotic agents" RELATED [ChEBI] +synonym: "atypical antipsychotic drug" RELATED [ChEBI] +synonym: "atypical antipsychotic drugs" RELATED [ChEBI] +synonym: "atypical antipsychotics" RELATED [ChEBI] +synonym: "second generation antipsychotic agent" RELATED [ChEBI] +synonym: "second generation antipsychotic agents" RELATED [ChEBI] +synonym: "second generation antipsychotic drug" RELATED [ChEBI] +synonym: "second generation antipsychotic drugs" RELATED [ChEBI] +synonym: "second generation antipsychotics" RELATED [ChEBI] +is_a: CHEBI:35476 ! antipsychotic agent + +[Term] +id: CHEBI:65207 +name: vascular endothelial growth factor receptor antagonist +namespace: chebi_ontology +def: "An antagonist at the vascular endothelial growth factor receptor." [] +subset: 3_STAR +synonym: "vascular endothelial growth factor receptor antagonists" RELATED [ChEBI] +synonym: "vascular endothelial growth factor receptor inhibitor" RELATED [ChEBI] +synonym: "vascular endothelial growth factor receptor inhibitors" RELATED [ChEBI] +synonym: "VEGF receptor inhibitor" RELATED [ChEBI] +synonym: "VEGF receptor inhibitors" RELATED [ChEBI] +synonym: "VEGFR inhibitor" RELATED [ChEBI] +synonym: "VEGFR inhibitors" RELATED [ChEBI] +xref: Wikipedia:VEGF_receptors +is_a: CHEBI:48706 ! antagonist + [Term] id: CHEBI:65212 name: polysaccharide derivative @@ -18562,6 +34213,52 @@ is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative relationship: has_functional_parent CHEBI:18154 ! polysaccharide +[Term] +id: CHEBI:65232 +name: EC 3.4.21.5 (thrombin) inhibitor +namespace: chebi_ontology +def: "An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5)." [] +subset: 3_STAR +synonym: "activated blood-coagulation factor II inhibitor" RELATED [ChEBI] +synonym: "activated blood-coagulation factor II inhibitors" RELATED [ChEBI] +synonym: "beta-thrombin inhibitor" RELATED [ChEBI] +synonym: "beta-thrombin inhibitors" RELATED [ChEBI] +synonym: "blood-coagulation factor IIa inhibitor" RELATED [ChEBI] +synonym: "blood-coagulation factor IIa inhibitors" RELATED [ChEBI] +synonym: "E thrombin inhibitor" RELATED [ChEBI] +synonym: "E thrombin inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.21.5 (thrombin) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.21.5 inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.21.5 inhibitors" RELATED [ChEBI] +synonym: "factor IIa inhibitor" RELATED [ChEBI] +synonym: "factor IIa inhibitors" RELATED [ChEBI] +synonym: "fibrinogenase inhibitor" RELATED [ChEBI] +synonym: "fibrinogenase inhibitors" RELATED [ChEBI] +synonym: "gamma-thrombin inhibitor" RELATED [ChEBI] +synonym: "gamma-thrombin inhibitors" RELATED [ChEBI] +synonym: "thrombase inhibitor" RELATED [ChEBI] +synonym: "thrombase inhibitors" RELATED [ChEBI] +synonym: "thrombin (EC 3.4.21.5) inhibitor" RELATED [ChEBI] +synonym: "thrombin (EC 3.4.21.5) inhibitors" RELATED [ChEBI] +synonym: "thrombin inhibitor" RELATED [ChEBI] +synonym: "thrombin inhibitors" RELATED [ChEBI] +synonym: "thrombin-C inhibitor" RELATED [ChEBI] +synonym: "thrombin-C inhibitors" RELATED [ChEBI] +synonym: "thrombofort inhibitor" RELATED [ChEBI] +synonym: "thrombofort inhibitors" RELATED [ChEBI] +synonym: "tropostasin inhibitor" RELATED [ChEBI] +synonym: "tropostasin inhibitors" RELATED [ChEBI] +is_a: CHEBI:5924 ! EC 3.4.21.* (serine endopeptidase) inhibitor + +[Term] +id: CHEBI:65234 +name: amidoxime +namespace: chebi_ontology +def: "Amidines of general formula RC(=NOH)NR(1)R(2), in which the imino nitrogen is substituted by a hydroxy group." [] +subset: 3_STAR +synonym: "amidoximes" RELATED [ChEBI] +is_a: CHEBI:2634 ! amidine + [Term] id: CHEBI:65255 name: food preservative @@ -18583,6 +34280,19 @@ synonym: "antimicrobial preservatives" RELATED [ChEBI] is_a: CHEBI:33281 ! antimicrobial agent is_a: CHEBI:65255 ! food preservative +[Term] +id: CHEBI:65259 +name: GABA antagonist +namespace: chebi_ontology +def: "A compound that inhibits the action of gamma-aminobutyric acid." [] +subset: 3_STAR +synonym: "GABA antagonists" RELATED [ChEBI] +synonym: "gamma-aminobutyric acid receptor antagonist" RELATED [ChEBI] +synonym: "gamma-aminobutyric acid receptor antagonists" RELATED [ChEBI] +xref: Wikipedia:GABA_antagonist +is_a: CHEBI:48706 ! antagonist +is_a: CHEBI:51374 ! GABA agent + [Term] id: CHEBI:65296 name: primary ammonium ion @@ -18616,6 +34326,81 @@ is_a: CHEBI:25905 ! peptide hormone is_a: CHEBI:33694 ! biomacromolecule relationship: has_role CHEBI:25512 ! neurotransmitter +[Term] +id: CHEBI:65321 +name: terpenoid indole alkaloid +namespace: chebi_ontology +def: "An indole alkaloid which is biosynthesised from L-tryptophan and isoprenoid building blocks." [] +subset: 3_STAR +synonym: "terpenoid indole alkaloids" RELATED [ChEBI] +is_a: CHEBI:38958 ! indole alkaloid + +[Term] +id: CHEBI:65323 +name: monoterpenoid indole alkaloid +namespace: chebi_ontology +def: "A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks." [] +subset: 3_STAR +synonym: "monoterpenoid indole alkaloids" RELATED [ChEBI] +xref: PMID:18280746 {source="Europe PMC"} +xref: PMID:20717879 {source="Europe PMC"} +xref: PMID:21425787 {source="Europe PMC"} +xref: PMID:22679912 {source="Europe PMC"} +is_a: CHEBI:65321 ! terpenoid indole alkaloid + +[Term] +id: CHEBI:6541 +name: losartan +namespace: chebi_ontology +def: "A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position" [] +subset: 3_STAR +synonym: "(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol" EXACT IUPAC_NAME [IUPAC] +synonym: "(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol" RELATED [IUPAC] +synonym: "2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole" RELATED [IUPHAR] +synonym: "Losartan" EXACT [KEGG_COMPOUND] +synonym: "losartan" RELATED INN [ChemIDplus] +xref: Beilstein:4770867 {source="Beilstein"} +xref: CAS:114798-26-4 {source="ChemIDplus"} +xref: CAS:114798-26-4 {source="KEGG COMPOUND"} +xref: Drug_Central:1610 {source="DrugCentral"} +xref: DrugBank:DB00678 +xref: HMDB:HMDB0014816 +xref: KEGG:C07072 +xref: KEGG:D08146 +xref: LINCS:LSM-3701 +xref: Patent:EP253310 +xref: Patent:US5138069 +xref: PMID:11115412 {source="Europe PMC"} +xref: PMID:11589260 {source="Europe PMC"} +xref: PMID:12561964 {source="Europe PMC"} +xref: PMID:15703421 {source="Europe PMC"} +xref: PMID:18800450 {source="Europe PMC"} +xref: PMID:18800451 {source="Europe PMC"} +xref: PMID:18800458 {source="Europe PMC"} +xref: PMID:18940180 {source="Europe PMC"} +xref: PMID:31299855 {source="Europe PMC"} +xref: PMID:31613648 {source="Europe PMC"} +xref: PMID:31636311 {source="Europe PMC"} +xref: PMID:31893179 {source="Europe PMC"} +xref: PMID:32048541 {source="Europe PMC"} +xref: Reaxys:4770867 {source="Reaxys"} +xref: Wikipedia:Losartan +is_a: CHEBI:24780 ! imidazoles +is_a: CHEBI:48420 ! biphenylyltetrazole +relationship: has_role CHEBI:35674 ! antihypertensive agent +relationship: has_role CHEBI:38070 ! anti-arrhythmia drug +relationship: has_role CHEBI:51451 ! endothelin receptor antagonist +relationship: has_role CHEBI:61016 ! angiotensin receptor antagonist +relationship: is_conjugate_acid_of CHEBI:149504 ! losartan(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H22ClN6O.K" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H23ClN6O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PSIFNNKUMBGKDQ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "422.91100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "422.16219" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1" xsd:string + [Term] id: CHEBI:66873 name: C4-dicarboxylic acid @@ -18626,6 +34411,61 @@ synonym: "C4-dicarboxylic acids" RELATED [ChEBI] is_a: CHEBI:35692 ! dicarboxylic acid relationship: is_conjugate_acid_of CHEBI:61336 ! C4-dicarboxylate +[Term] +id: CHEBI:66901 +name: ivacaftor +namespace: chebi_ontology +def: "An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis." [] +subset: 3_STAR +synonym: "ivacaftor" RELATED INN [WHO_MedNet] +synonym: "ivacaftor" RELATED INN [KEGG_DRUG] +synonym: "ivacaftorum" RELATED INN [WHO_MedNet] +synonym: "Kalydeco" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "VX-770" RELATED [ChemIDplus] +xref: CAS:873054-44-5 {source="KEGG DRUG"} +xref: CAS:873054-44-5 {source="ChemIDplus"} +xref: Drug_Central:4228 {source="DrugCentral"} +xref: KEGG:D09916 +xref: PMID:22047557 {source="Europe PMC"} +xref: PMID:22293084 {source="Europe PMC"} +xref: PMID:22383668 {source="Europe PMC"} +xref: PMID:22499233 {source="Europe PMC"} +xref: PMID:22508750 {source="Europe PMC"} +xref: PMID:22543461 {source="Europe PMC"} +xref: PMID:22618984 {source="Europe PMC"} +xref: PMID:22698459 {source="Europe PMC"} +xref: PMID:22723294 {source="Europe PMC"} +xref: PMID:22739718 {source="Europe PMC"} +xref: PMID:22768130 {source="Europe PMC"} +xref: Reaxys:11821038 {source="Reaxys"} +xref: Wikipedia:Ivacaftor +is_a: CHEBI:23765 ! quinolone +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:33853 ! phenols +is_a: CHEBI:62733 ! aromatic amide +relationship: has_role CHEBI:66902 ! CFTR potentiator +relationship: has_role CHEBI:71031 ! orphan drug +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H28N2O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PURKAOJPTOLRMP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "392.49070" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "392.20999" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C" xsd:string + +[Term] +id: CHEBI:66902 +name: CFTR potentiator +namespace: chebi_ontology +def: "A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes." [] +subset: 3_STAR +synonym: "CFTR potentiators" RELATED [ChEBI] +synonym: "cystic fibrosis transmembrane conductance regulator potentiator" RELATED [ChEBI] +synonym: "cystic fibrosis transmembrane conductance regulator potentiators" RELATED [ChEBI] +xref: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator +is_a: CHEBI:38632 ! membrane transport modulator + [Term] id: CHEBI:66924 name: creatinate @@ -18664,6 +34504,21 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "134.17700" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.02812" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(CCS)C([O-])=O" xsd:string +[Term] +id: CHEBI:66956 +name: antidyskinesia agent +namespace: chebi_ontology +def: "Any compound which can be used to treat or alleviate the symptoms of dyskinesia." [] +subset: 3_STAR +synonym: "antidyskinesia agents" RELATED [ChEBI] +synonym: "antidyskinesia drug" RELATED [ChEBI] +synonym: "antidyskinesia drugs" RELATED [ChEBI] +synonym: "antidyskinetic agent" RELATED [ChEBI] +synonym: "antidyskinetic agents" RELATED [ChEBI] +synonym: "antidyskinetic drug" RELATED [ChEBI] +synonym: "antidyskinetic drugs" RELATED [ChEBI] +is_a: CHEBI:23888 ! drug + [Term] id: CHEBI:67011 name: folates @@ -18677,6 +34532,16 @@ is_a: CHEBI:176842 ! vitamin B9 is_a: CHEBI:59874 ! N-acyl-L-alpha-amino acid anion relationship: is_conjugate_base_of CHEBI:37445 ! folic acids +[Term] +id: CHEBI:67013 +name: methyl-branched fatty acid anion +namespace: chebi_ontology +def: "Any branched-chain fatty acid anion containing methyl branches only." [] +subset: 3_STAR +synonym: "methyl-branched fatty acid anions" RELATED [ChEBI] +is_a: CHEBI:58955 ! branched-chain fatty acid anion +relationship: is_conjugate_base_of CHEBI:62499 ! methyl-branched fatty acid + [Term] id: CHEBI:67079 name: anti-inflammatory agent @@ -18688,6 +34553,22 @@ synonym: "antiinflammatory agent" RELATED [ChEBI] synonym: "antiinflammatory agents" RELATED [ChEBI] is_a: CHEBI:33232 ! application +[Term] +id: CHEBI:67142 +name: nucleobase analogue +namespace: chebi_ontology +def: "A molecule that can substitute for a normal nucleobase in nucleic acids." [] +subset: 3_STAR +synonym: "base analog" RELATED [ChEBI] +synonym: "base analogs" RELATED [ChEBI] +synonym: "base analogue" RELATED [ChEBI] +synonym: "base analogues" RELATED [ChEBI] +synonym: "nucleobase analog" RELATED [ChEBI] +synonym: "nucleobase analogs" RELATED [ChEBI] +synonym: "nucleobase analogues" RELATED [ChEBI] +xref: Wikipedia:Base_analog +is_a: CHEBI:33832 ! organic cyclic compound + [Term] id: CHEBI:67200 name: provitamin A @@ -18697,6 +34578,177 @@ subset: 3_STAR synonym: "provitamin As" RELATED [ChEBI] is_a: CHEBI:50188 ! provitamin +[Term] +id: CHEBI:67268 +name: HIV-1 integrase inhibitor +namespace: chebi_ontology +def: "An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells." [] +subset: 3_STAR +xref: Wikipedia:Discovery_and_development_of_integrase_inhibitors +is_a: CHEBI:64947 ! anti-HIV-1 agent +is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor + +[Term] +id: CHEBI:6801 +name: metformin +namespace: chebi_ontology +def: "A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1." [] +subset: 3_STAR +synonym: "1,1-dimethylbiguanide" RELATED [ChemIDplus] +synonym: "dimethylbiguanide" RELATED [ChemIDplus] +synonym: "dimethyldiguanide" RELATED [ChemIDplus] +synonym: "LA 6023" RELATED [DrugBank] +synonym: "LA-6023" RELATED [ChemIDplus] +synonym: "metformin" RELATED INN [WHO_MedNet] +synonym: "metformina" RELATED INN [WHO_MedNet] +synonym: "metformine" RELATED INN [WHO_MedNet] +synonym: "metforminum" RELATED INN [WHO_MedNet] +synonym: "N(1),N(1)-dimethylbiguanide" RELATED [ChemIDplus] +synonym: "N,N-dimethylbiguanide" RELATED [ChemIDplus] +synonym: "N,N-dimethyldiguanide" RELATED [ChemIDplus] +synonym: "N,N-dimethylguanylguanidine" RELATED [DrugCentral] +synonym: "N,N-dimethylimidodicarbonimidic diamide" RELATED [IUPAC] +synonym: "N,N-dimethyltriimidodicarbonic diamide" EXACT IUPAC_NAME [IUPAC] +xref: CAS:657-24-9 {source="ChemIDplus"} +xref: CAS:657-24-9 {source="KEGG COMPOUND"} +xref: Drug_Central:1725 {source="DrugCentral"} +xref: DrugBank:DB00331 +xref: FooDB:FDB022739 +xref: HMDB:HMDB0001921 +xref: KEGG:C07151 +xref: KEGG:D04966 +xref: LINCS:LSM-4730 +xref: PDBeChem:MF8 +xref: PMID:10900588 {source="Europe PMC"} +xref: PMID:10983737 {source="Europe PMC"} +xref: PMID:10999803 {source="Europe PMC"} +xref: PMID:11012555 {source="Europe PMC"} +xref: PMID:11126815 {source="Europe PMC"} +xref: PMID:11192132 {source="Europe PMC"} +xref: PMID:11257323 {source="Europe PMC"} +xref: PMID:11544610 {source="Europe PMC"} +xref: PMID:11772907 {source="Europe PMC"} +xref: PMID:12086935 {source="Europe PMC"} +xref: PMID:12406042 {source="Europe PMC"} +xref: PMID:12436333 {source="Europe PMC"} +xref: PMID:12630933 {source="Europe PMC"} +xref: PMID:12909816 {source="Europe PMC"} +xref: PMID:15261814 {source="Europe PMC"} +xref: PMID:15606381 {source="Europe PMC"} +xref: PMID:15650645 {source="Europe PMC"} +xref: PMID:15717887 {source="Europe PMC"} +xref: PMID:15932841 {source="Europe PMC"} +xref: PMID:16294070 {source="Europe PMC"} +xref: PMID:16520442 {source="Europe PMC"} +xref: PMID:16941277 {source="Europe PMC"} +xref: PMID:17062558 {source="Europe PMC"} +xref: PMID:18212742 {source="Europe PMC"} +xref: PMID:18608522 {source="Europe PMC"} +xref: PMID:23077661 {source="Europe PMC"} +xref: PMID:23540700 {source="Europe PMC"} +xref: PMID:24428821 {source="Europe PMC"} +xref: PMID:28919040 {source="Europe PMC"} +xref: PMID:31208831 {source="Europe PMC"} +xref: PMID:33191721 {source="Europe PMC"} +xref: Reaxys:606492 {source="Reaxys"} +xref: Wikipedia:Metformin +is_a: CHEBI:24436 ! guanidines +relationship: has_functional_parent CHEBI:3095 ! biguanide +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35526 ! hypoglycemic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_base_of CHEBI:90688 ! metformin(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H11N5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XZWYZXLIPXDOLR-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "129.167" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "129.10145" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)C(=N)NC(N)=N" xsd:string + +[Term] +id: CHEBI:6809 +name: methamphetamine +namespace: chebi_ontology +def: "A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent." [] +subset: 3_STAR +synonym: "(+)-(S)-N-alpha-dimethylphenethylamine" RELATED [NIST_Chemistry_WebBook] +synonym: "(2S)-N-methyl-1-phenylpropan-2-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "(alphaS)-N,alpha-dimethylbenzeneethanamine" RELATED [ChemIDplus] +synonym: "(S)-N,alpha-dimethylbenzeneethanamine" RELATED [ChemIDplus] +synonym: "d-1-phenyl-2-methylaminopropane" RELATED [ChemIDplus] +synonym: "d-deoxyephedrine" RELATED [ChemIDplus] +synonym: "d-desoxyephedrine" RELATED [ChemIDplus] +synonym: "d-N-methylamphetamine" RELATED [ChemIDplus] +synonym: "d-phenylisopropylmethylamine" RELATED [ChemIDplus] +synonym: "dextromethamphetamine" RELATED [ChEBI] +synonym: "metamfetamine" RELATED INN [WHO_MedNet] +synonym: "metamfetaminum" RELATED INN [WHO_MedNet] +synonym: "metanfetamina" RELATED INN [WHO_MedNet] +synonym: "Methamphetamine" EXACT [KEGG_COMPOUND] +synonym: "methyl-beta-phenylisopropylamine" RELATED [NIST_Chemistry_WebBook] +xref: Beilstein:2207147 {source="Beilstein"} +xref: CAS:537-46-2 {source="NIST Chemistry WebBook"} +xref: CAS:537-46-2 {source="KEGG COMPOUND"} +xref: CAS:537-46-2 {source="ChemIDplus"} +xref: Drug_Central:1732 {source="DrugCentral"} +xref: DrugBank:DB01577 +xref: HMDB:HMDB0015517 +xref: KEGG:C07164 +xref: KEGG:D08187 +xref: PDBeChem:B40 +xref: PMID:11221576 {source="Europe PMC"} +xref: PMID:11406298 {source="Europe PMC"} +xref: PMID:11711870 {source="Europe PMC"} +xref: PMID:11717374 {source="Europe PMC"} +xref: PMID:11829406 {source="Europe PMC"} +xref: PMID:11831503 {source="Europe PMC"} +xref: PMID:11847428 {source="Europe PMC"} +xref: PMID:11896153 {source="Europe PMC"} +xref: PMID:11984857 {source="Europe PMC"} +xref: PMID:14645148 {source="Europe PMC"} +xref: PMID:14769818 {source="Europe PMC"} +xref: PMID:15380623 {source="Europe PMC"} +xref: PMID:15542724 {source="Europe PMC"} +xref: PMID:15542728 {source="Europe PMC"} +xref: PMID:15808793 {source="Europe PMC"} +xref: PMID:18279499 {source="Europe PMC"} +xref: PMID:18509037 {source="Europe PMC"} +xref: PMID:18521756 {source="Europe PMC"} +xref: PMID:18991860 {source="Europe PMC"} +xref: PMID:18991862 {source="Europe PMC"} +xref: PMID:19269222 {source="Europe PMC"} +xref: PMID:19384581 {source="Europe PMC"} +xref: PMID:19576287 {source="Europe PMC"} +xref: PMID:19732271 {source="Europe PMC"} +xref: PMID:24349338 {source="Europe PMC"} +xref: PMID:25724762 {source="Europe PMC"} +xref: PMID:26302754 {source="Europe PMC"} +xref: PMID:26541330 {source="Europe PMC"} +xref: PMID:26568405 {source="Europe PMC"} +xref: PMID:26683901 {source="Europe PMC"} +xref: PMID:26775284 {source="Europe PMC"} +xref: PMID:26992824 {source="Europe PMC"} +xref: PMID:27232669 {source="Europe PMC"} +xref: Reaxys:2207147 {source="Reaxys"} +xref: Wikipedia:Methamphetamine +is_a: CHEBI:32863 ! secondary amine +is_a: CHEBI:35338 ! amphetamines +relationship: has_functional_parent CHEBI:4469 ! (S)-amphetamine +relationship: has_role CHEBI:35471 ! psychotropic drug +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:50910 ! neurotoxin +relationship: has_role CHEBI:78298 ! environmental contaminant +relationship: is_conjugate_base_of CHEBI:132297 ! methamphetamine(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H15N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYWUZJCMWCOHBA-VIFPVBQESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "149.23284" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "149.12045" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN[C@@H](C)Cc1ccccc1" xsd:string + [Term] id: CHEBI:68452 name: azole @@ -18708,6 +34760,115 @@ xref: Wikipedia:Azole is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38179 ! monocyclic heteroarene +[Term] +id: CHEBI:68472 +name: pyrimidine deoxyribonucleoside +namespace: chebi_ontology +def: "A deoxyribonucleoside containing a pyrimidine base." [] +subset: 3_STAR +synonym: "pyrimidine deoxyribonucleosides" RELATED [ChEBI] +xref: MetaCyc:Pyrimidine-Deoxyribonucleosides +is_a: CHEBI:23636 ! deoxyribonucleoside +is_a: CHEBI:26440 ! pyrimidine nucleoside + +[Term] +id: CHEBI:68481 +name: mTOR inhibitor +namespace: chebi_ontology +def: "A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer." [] +subset: 3_STAR +synonym: "mammalian target of rapamycin inhibitor" RELATED [ChEBI] +synonym: "mammalian target of rapamycin inhibitors" RELATED [ChEBI] +synonym: "mTOR inhibitors" RELATED [ChEBI] +xref: Wikipedia:MTOR_inhibitors +is_a: CHEBI:37699 ! protein kinase inhibitor + +[Term] +id: CHEBI:68495 +name: apoptosis inducer +namespace: chebi_ontology +def: "Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms." [] +subset: 3_STAR +synonym: "apoptosis inducers" RELATED [ChEBI] +synonym: "Type I cell-death inducer" RELATED [ChEBI] +synonym: "Type I cell-death inducers" RELATED [ChEBI] +synonym: "Type I programmed cell-death inducer" RELATED [ChEBI] +synonym: "Type I programmed cell-death inducers" RELATED [ChEBI] +is_a: CHEBI:52206 ! biochemical role + +[Term] +id: CHEBI:68563 +name: P2Y12 receptor antagonist +namespace: chebi_ontology +def: "An antagonist at the P2Y12 receptor" [] +subset: 3_STAR +synonym: "ADP receptor subtype P2Y12 antagonist" RELATED [ChEBI] +synonym: "ADP receptor subtype P2Y12 antagonists" RELATED [ChEBI] +synonym: "P2Y12 receptor antagonists" RELATED [ChEBI] +synonym: "purinergic receptor subtype P2Y12 antagonist" RELATED [ChEBI] +synonym: "purinergic receptor subtype P2Y12 antagonists" RELATED [ChEBI] +xref: Wikipedia:P2Y12 +is_a: CHEBI:91079 ! purinergic receptor P2 antagonist + +[Term] +id: CHEBI:6887 +name: methylphenidate +namespace: chebi_ontology +def: "A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy." [] +subset: 3_STAR +synonym: "Daytrana" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "dl-threo-methylphenidate" RELATED [ChemIDplus] +synonym: "methyl rac-threo-alpha-phenyl-alpha-2-piperidinylacetate" RELATED [ChEBI] +synonym: "methyl rac-threo-phenidylacetate" RELATED [ChEBI] +synonym: "methylphenidan" RELATED [ChemIDplus] +synonym: "methylphenidate" RELATED INN [WHO_MedNet] +synonym: "methylphenidate" RELATED INN [KEGG_DRUG] +synonym: "methylphenidatum" RELATED INN [ChemIDplus] +synonym: "metilfenidato" RELATED INN [ChemIDplus] +synonym: "rac-methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate" EXACT IUPAC_NAME [IUPAC] +synonym: "rac-threo-alpha-phenyl-2-piperidineacetic acid methyl ester" RELATED [ChEBI] +synonym: "rac-threo-methyl alpha-phenyl-alpha-(2-piperidyl)acetate" RELATED [ChEBI] +synonym: "threo-(+-)-methylphenidate" RELATED [ChemIDplus] +xref: Beilstein:200061 {source="Beilstein"} +xref: CAS:113-45-1 {source="NIST Chemistry WebBook"} +xref: CAS:113-45-1 {source="KEGG COMPOUND"} +xref: CAS:20748-11-2 {source="ChemIDplus"} +xref: DrugBank:DB00422 +xref: HMDB:HMDB0014566 +xref: KEGG:C07196 +xref: KEGG:D04999 +xref: Patent:US2507631 +xref: Patent:US2957880 +xref: PMID:10786896 {source="Europe PMC"} +xref: PMID:11160455 {source="Europe PMC"} +xref: PMID:11862378 {source="Europe PMC"} +xref: PMID:16953648 {source="Europe PMC"} +xref: PMID:17201613 {source="Europe PMC"} +xref: PMID:18670250 {source="Europe PMC"} +xref: PMID:18978488 {source="Europe PMC"} +xref: PMID:22098932 {source="Europe PMC"} +xref: PMID:23104969 {source="Europe PMC"} +xref: PMID:23813595 {source="Europe PMC"} +xref: PMID:23975034 {source="Europe PMC"} +xref: PMID:25433180 {source="Europe PMC"} +xref: PMID:25449360 {source="Europe PMC"} +xref: PMID:25553710 {source="Europe PMC"} +xref: Reaxys:200061 {source="Reaxys"} +xref: Wikipedia:Methylphenidate +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:51857 ! methyl (S)-phenyl[(S)-piperidin-2-yl]acetate +relationship: has_part CHEBI:51860 ! dexmethylphenidate +relationship: has_role CHEBI:35337 ! central nervous system stimulant +relationship: has_role CHEBI:35471 ! psychotropic drug +relationship: has_role CHEBI:35524 ! sympathomimetic agent +relationship: has_role CHEBI:35640 ! adrenergic uptake inhibitor +relationship: has_role CHEBI:51039 ! dopamine uptake inhibitor +relationship: is_conjugate_base_of CHEBI:51856 ! methylphenidate(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H19NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "233.307" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "233.14158" xsd:string + [Term] id: CHEBI:7044 name: myoglobin @@ -18730,6 +34891,405 @@ synonym: "PR agonists" RELATED [ChEBI] synonym: "progesterone receptor agonists" RELATED [ChEBI] is_a: CHEBI:51060 ! hormone agonist +[Term] +id: CHEBI:70727 +name: topoisomerase inhibitor +namespace: chebi_ontology +def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." [] +subset: 3_STAR +synonym: "topoisomerase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Topoisomerase +is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor + +[Term] +id: CHEBI:70746 +name: dabigatran etexilate +namespace: chebi_ontology +def: "An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amino group of ethyl N-pyridin-2-yl-beta-alaninate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism." [] +subset: 3_STAR +synonym: "dabigatran etexilate" RELATED INN [KEGG_DRUG] +synonym: "ethyl N-[(2-{[(4-{N'-[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl]-N-pyridin-2-yl-beta-alaninate" EXACT IUPAC_NAME [IUPAC] +xref: CAS:211915-06-9 {source="KEGG DRUG"} +xref: CAS:211915-06-9 {source="ChemIDplus"} +xref: Drug_Central:776 {source="DrugCentral"} +xref: HMDB:HMDB0015641 +xref: KEGG:D07144 +xref: Patent:US2011275824 +xref: Patent:WO2007047608 +xref: Patent:WO2011061080 +xref: Patent:WO2012027543 +xref: Patent:WO2012077136 +xref: PMID:21265583 {source="Europe PMC"} +xref: PMID:21429525 {source="Europe PMC"} +xref: PMID:21542663 {source="Europe PMC"} +xref: PMID:21748501 {source="Europe PMC"} +xref: PMID:21859976 {source="Europe PMC"} +xref: PMID:21881389 {source="Europe PMC"} +xref: PMID:22252796 {source="Europe PMC"} +xref: PMID:22276081 {source="Europe PMC"} +xref: PMID:22298812 {source="Europe PMC"} +xref: PMID:22318514 {source="Europe PMC"} +xref: PMID:22348256 {source="Europe PMC"} +xref: PMID:22422743 {source="Europe PMC"} +xref: PMID:22431533 {source="Europe PMC"} +xref: PMID:22488474 {source="Europe PMC"} +xref: PMID:22536678 {source="Europe PMC"} +xref: PMID:22552763 {source="Europe PMC"} +xref: PMID:22563715 {source="Europe PMC"} +xref: PMID:22564134 {source="Europe PMC"} +xref: PMID:22669799 {source="Europe PMC"} +xref: PMID:22782539 {source="Europe PMC"} +xref: PMID:22803489 {source="Europe PMC"} +xref: PMID:22995531 {source="Europe PMC"} +xref: PMID:23476049 {source="Europe PMC"} +xref: Reaxys:15496119 {source="Reaxys"} +is_a: CHEBI:22715 ! benzimidazoles +is_a: CHEBI:22823 ! beta-alanine derivative +is_a: CHEBI:26421 ! pyridines +is_a: CHEBI:33308 ! carboxylic ester +is_a: CHEBI:35359 ! carboxamidine +is_a: CHEBI:62733 ! aromatic amide +relationship: has_functional_parent CHEBI:70752 ! dabigatran +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:65232 ! EC 3.4.21.5 (thrombin) inhibitor +relationship: is_conjugate_base_of CHEBI:70751 ! dabigatran etexilate(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C34H41N7O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KSGXQBZTULBEEQ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "627.73320" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "627.31692" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCCCCCOC(=O)\\N=C(\\N)c1ccc(NCc2nc3cc(ccc3n2C)C(=O)N(CCC(=O)OCC)c2ccccn2)cc1" xsd:string + +[Term] +id: CHEBI:70751 +name: dabigatran etexilate(1+) +namespace: chebi_ontology +def: "An organic cation that is the conjugate acid of dabigatran etexilate." [] +subset: 3_STAR +synonym: "dabigatran etexilate cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +relationship: is_conjugate_acid_of CHEBI:70746 ! dabigatran etexilate +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C34H42N7O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C34H41N7O5/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44)/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KSGXQBZTULBEEQ-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "628.74120" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "628.32419" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H+].CCCCCCOC(=O)\\N=C(\\N)c1ccc(NCc2nc3cc(ccc3n2C)C(=O)N(CCC(=O)OCC)c2ccccn2)cc1" xsd:string + +[Term] +id: CHEBI:70752 +name: dabigatran +namespace: chebi_ontology +def: "An aromatic amide obtained by formal condensation of the carboxy group of 2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-benzimidazole-5-carboxylic acid with the secondary amoino group of N-pyridin-2-yl-beta-alanine. The active metabolite of the prodrug dabigatran etexilate, it acts as an anticoagulant which is used for the prevention of stroke and systemic embolism." [] +subset: 3_STAR +synonym: "dabigatran" RELATED INN [KEGG_DRUG] +xref: CAS:211914-51-1 {source="KEGG DRUG"} +xref: KEGG:D09707 +xref: Patent:US2006222640 +xref: Patent:US2008015176 +xref: Patent:US6087380 +xref: Patent:WO2004014894 +xref: Patent:WO2006004575 +xref: Patent:WO2006103206 +xref: Patent:WO2008009638 +xref: Patent:WO2008009639 +xref: PMID:21956605 {source="Europe PMC"} +xref: PMID:22215856 {source="Europe PMC"} +xref: PMID:22227958 {source="Europe PMC"} +xref: PMID:22314599 {source="Europe PMC"} +xref: PMID:22378612 {source="Europe PMC"} +xref: PMID:22411291 {source="Europe PMC"} +xref: PMID:22413715 {source="Europe PMC"} +xref: PMID:22431533 {source="Europe PMC"} +xref: PMID:22458575 {source="Europe PMC"} +xref: PMID:22494098 {source="Europe PMC"} +xref: PMID:22595629 {source="Europe PMC"} +xref: PMID:22612026 {source="Europe PMC"} +xref: PMID:22645678 {source="Europe PMC"} +xref: PMID:22700854 {source="Europe PMC"} +xref: PMID:22722043 {source="Europe PMC"} +xref: PMID:22740145 {source="Europe PMC"} +xref: PMID:22786838 {source="Europe PMC"} +xref: PMID:22834159 {source="Europe PMC"} +xref: PMID:22854367 {source="Europe PMC"} +xref: PMID:23020832 {source="Europe PMC"} +xref: PMID:23476049 {source="Europe PMC"} +xref: Reaxys:9168207 {source="Reaxys"} +xref: Wikipedia:Dabigatran +is_a: CHEBI:22715 ! benzimidazoles +is_a: CHEBI:22823 ! beta-alanine derivative +is_a: CHEBI:26421 ! pyridines +is_a: CHEBI:35359 ! carboxamidine +is_a: CHEBI:62733 ! aromatic amide +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:65232 ! EC 3.4.21.5 (thrombin) inhibitor +relationship: has_role CHEBI:77020 ! EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C25H25N7O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YBSJFWOBGCMAKL-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "471.51110" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "471.20189" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1" xsd:string + +[Term] +id: CHEBI:70868 +name: antileishmanial agent +namespace: chebi_ontology +def: "An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania." [] +subset: 3_STAR +synonym: "antileishmanial agents" RELATED [ChEBI] +synonym: "antileishmanial drug" RELATED [ChEBI] +synonym: "antileishmanial drugs" RELATED [ChEBI] +is_a: CHEBI:35820 ! antiprotozoal drug + +[Term] +id: CHEBI:71019 +name: omacetaxine mepesuccinate +namespace: chebi_ontology +def: "A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia." [] +subset: 3_STAR +synonym: "(-)-homoharringtonine" RELATED [ChEBI] +synonym: "(2'R,3S,4S,5R)-(-)-homoharringtonine" RELATED [ChEBI] +synonym: "CGX-635" RELATED [ChemIDplus] +synonym: "Homoharringtonine" RELATED [KEGG_DRUG] +synonym: "mepesuccinate d'omacetaxine" RELATED INN [WHO_MedNet] +synonym: "mepesuccinato de omacetaxina" RELATED INN [WHO_MedNet] +synonym: "omacetaxine mepesuccinate" RELATED INN [WHO_MedNet] +synonym: "omacetaxini mepesuccinas" RELATED INN [WHO_MedNet] +synonym: "Synribo" RELATED BRAND_NAME [ChemIDplus] +xref: Beilstein:5687925 {source="ChemIDplus"} +xref: CAS:26833-87-4 {source="KEGG DRUG"} +xref: CAS:26833-87-4 {source="ChemIDplus"} +xref: Drug_Central:4677 {source="DrugCentral"} +xref: KEGG:D08956 +xref: LINCS:LSM-3716 +xref: Patent:US2010240887 +xref: Patent:WO2007089878 +xref: PDBeChem:HMT +xref: PMID:20971952 {source="Europe PMC"} +xref: PMID:21152934 {source="Europe PMC"} +xref: PMID:21258877 {source="Europe PMC"} +xref: PMID:21294709 {source="Europe PMC"} +xref: PMID:21415308 {source="Europe PMC"} +xref: PMID:21418889 {source="Europe PMC"} +xref: PMID:21468038 {source="Europe PMC"} +xref: PMID:21509439 {source="Europe PMC"} +xref: PMID:21845438 {source="Europe PMC"} +xref: PMID:21916787 {source="Europe PMC"} +xref: PMID:22040954 {source="Europe PMC"} +xref: PMID:22054289 {source="Europe PMC"} +xref: PMID:22075327 {source="Europe PMC"} +xref: PMID:22289991 {source="Europe PMC"} +xref: PMID:22391162 {source="Europe PMC"} +xref: PMID:22580751 {source="Europe PMC"} +xref: PMID:22714632 {source="Europe PMC"} +xref: PMID:22896000 {source="Europe PMC"} +xref: PMID:22898909 {source="Europe PMC"} +xref: PMID:22917222 {source="Europe PMC"} +xref: PMID:22967374 {source="Europe PMC"} +xref: PMID:23053254 {source="Europe PMC"} +xref: PMID:23059828 {source="Europe PMC"} +xref: PMID:23086639 {source="Europe PMC"} +xref: PMID:23109844 {source="Europe PMC"} +xref: PMID:23456623 {source="Europe PMC"} +xref: Reaxys:5687925 {source="Reaxys"} +xref: Wikipedia:Omacetaxine_mepesuccinate +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:38164 ! organic heteropentacyclic compound +is_a: CHEBI:38481 ! alkaloid ester +is_a: CHEBI:47985 ! enol ether +relationship: has_functional_parent CHEBI:3540 ! cephalotaxine +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:48001 ! protein synthesis inhibitor +relationship: has_role CHEBI:68495 ! apoptosis inducer +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C29H39NO9" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HYFHYPWGAURHIV-JFIAXGOJSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "545.62130" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "545.26248" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21" xsd:string + +[Term] +id: CHEBI:71031 +name: orphan drug +namespace: chebi_ontology +def: "Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease." [] +subset: 3_STAR +synonym: "orphan drugs" RELATED [ChEBI] +xref: PMID:20036435 {source="Europe PMC"} +xref: PMID:20800761 {source="Europe PMC"} +xref: PMID:21180460 {source="Europe PMC"} +xref: PMID:21682893 {source="Europe PMC"} +xref: PMID:21947805 {source="Europe PMC"} +xref: PMID:22363762 {source="Europe PMC"} +xref: PMID:22366309 {source="Europe PMC"} +xref: PMID:22371464 {source="Europe PMC"} +xref: PMID:22731105 {source="Europe PMC"} +xref: PMID:22739138 {source="Europe PMC"} +xref: PMID:22747423 {source="Europe PMC"} +xref: PMID:22814659 {source="Europe PMC"} +xref: PMID:22814660 {source="Europe PMC"} +xref: PMID:22973866 {source="Europe PMC"} +xref: PMID:22981668 {source="Europe PMC"} +xref: PMID:22989856 {source="Europe PMC"} +xref: PMID:23013790 {source="Europe PMC"} +xref: PMID:23090701 {source="Europe PMC"} +xref: PMID:23109143 {source="Europe PMC"} +xref: PMID:23129684 {source="Europe PMC"} +xref: Wikipedia:Orphan_drug +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:71200 +name: tofacitinib +namespace: chebi_ontology +def: "A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis." [] +subset: 3_STAR +synonym: "3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile" EXACT IUPAC_NAME [IUPAC] +synonym: "CP 690550" RELATED [DrugCentral] +synonym: "CP-690550" RELATED [DrugCentral] +synonym: "Tasocitinib" RELATED [KEGG_DRUG] +synonym: "tofacitinib" RELATED INN [WHO_MedNet] +synonym: "tofacitinibum" RELATED INN [WHO_MedNet] +xref: CAS:477600-75-2 {source="ChemIDplus"} +xref: CAS:477600-75-2 {source="KEGG DRUG"} +xref: Drug_Central:4713 {source="DrugCentral"} +xref: KEGG:D09970 +xref: LINCS:LSM-1227 +xref: Patent:WO2007012953 +xref: Patent:WO2007107318 +xref: Patent:WO2010123919 +xref: PDBeChem:MI1 +xref: PMID:21952978 {source="Europe PMC"} +xref: PMID:21971513 {source="Europe PMC"} +xref: PMID:22006202 {source="Europe PMC"} +xref: PMID:22147632 {source="Europe PMC"} +xref: PMID:22233204 {source="Europe PMC"} +xref: PMID:22357358 {source="Europe PMC"} +xref: PMID:22460142 {source="Europe PMC"} +xref: PMID:22474037 {source="Europe PMC"} +xref: PMID:22525048 {source="Europe PMC"} +xref: PMID:22576568 {source="Europe PMC"} +xref: PMID:22591402 {source="Europe PMC"} +xref: PMID:22607178 {source="Europe PMC"} +xref: PMID:22607938 {source="Europe PMC"} +xref: PMID:22682022 {source="Europe PMC"} +xref: PMID:22802024 {source="Europe PMC"} +xref: PMID:22873530 {source="Europe PMC"} +xref: PMID:22873531 {source="Europe PMC"} +xref: PMID:22894574 {source="Europe PMC"} +xref: PMID:22899318 {source="Europe PMC"} +xref: PMID:22916341 {source="Europe PMC"} +xref: PMID:22924949 {source="Europe PMC"} +xref: PMID:22960764 {source="Europe PMC"} +xref: PMID:23055694 {source="Europe PMC"} +xref: PMID:23150969 {source="Europe PMC"} +xref: PMID:23150970 {source="Europe PMC"} +xref: PMID:23150971 {source="Europe PMC"} +xref: Reaxys:11647225 {source="Reaxys"} +xref: Wikipedia:Tofacitinib +is_a: CHEBI:18379 ! nitrile +is_a: CHEBI:38670 ! pyrrolopyrimidine +is_a: CHEBI:48591 ! N-acylpiperidine +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_role CHEBI:35842 ! antirheumatic drug +relationship: has_role CHEBI:76617 ! EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C16H20N6O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UJLAWZDWDVHWOW-YPMHNXCESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "312.36960" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "312.16986" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N" xsd:string + +[Term] +id: CHEBI:71218 +name: pazopanib(1+) +namespace: chebi_ontology +def: "An organic cation that is the conjugate acid of pazopanib." [] +subset: 3_STAR +synonym: "pazopanib cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +relationship: is_conjugate_acid_of CHEBI:71219 ! pazopanib +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H24N7O2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CUIHSIWYWATEQL-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "438.52600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "438.17067" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H+].C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C" xsd:string + +[Term] +id: CHEBI:71219 +name: pazopanib +namespace: chebi_ontology +def: "A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer." [] +subset: 3_STAR +synonym: "5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "GW 78603" RELATED [ChemIDplus] +synonym: "GW786034" RELATED [ChemIDplus] +synonym: "pazopanib" RELATED INN [WHO_MedNet] +synonym: "pazopanibum" RELATED INN [WHO_MedNet] +xref: CAS:444731-52-6 {source="ChemIDplus"} +xref: Drug_Central:4118 {source="DrugCentral"} +xref: LINCS:LSM-1114 +xref: Patent:US2008293691 +xref: Patent:WO2006020564 +xref: Patent:WO2007064753 +xref: Patent:WO2007143483 +xref: Patent:WO2011058179 +xref: Patent:WO2011069053 +xref: Patent:WO2011150044 +xref: Patent:WO2012106302 +xref: PMID:21394443 {source="Europe PMC"} +xref: PMID:21766486 {source="Europe PMC"} +xref: PMID:21811833 {source="Europe PMC"} +xref: PMID:22112314 {source="Europe PMC"} +xref: PMID:22190407 {source="Europe PMC"} +xref: PMID:22233389 {source="Europe PMC"} +xref: PMID:22341567 {source="Europe PMC"} +xref: PMID:22359392 {source="Europe PMC"} +xref: PMID:22595799 {source="Europe PMC"} +xref: PMID:22679111 {source="Europe PMC"} +xref: PMID:22688250 {source="Europe PMC"} +xref: PMID:22716487 {source="Europe PMC"} +xref: PMID:22733110 {source="Europe PMC"} +xref: PMID:22733795 {source="Europe PMC"} +xref: PMID:22759480 {source="Europe PMC"} +xref: PMID:22766517 {source="Europe PMC"} +xref: PMID:22830347 {source="Europe PMC"} +xref: PMID:22861374 {source="Europe PMC"} +xref: PMID:22917595 {source="Europe PMC"} +xref: PMID:22984765 {source="Europe PMC"} +xref: PMID:23054212 {source="Europe PMC"} +xref: PMID:23064954 {source="Europe PMC"} +xref: PMID:23072642 {source="Europe PMC"} +xref: PMID:23088634 {source="Europe PMC"} +xref: PMID:23135778 {source="Europe PMC"} +xref: Reaxys:11646488 {source="Reaxys"} +xref: Wikipedia:Pazopanib +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:38338 ! aminopyrimidine +is_a: CHEBI:38769 ! indazoles +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:38637 ! tyrosine kinase inhibitor +relationship: has_role CHEBI:50926 ! angiogenesis modulating agent +relationship: has_role CHEBI:65207 ! vascular endothelial growth factor receptor antagonist +relationship: is_conjugate_base_of CHEBI:71218 ! pazopanib(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H23N7O2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CUIHSIWYWATEQL-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "437.520" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "437.16339" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C" xsd:string + [Term] id: CHEBI:71300 name: EC 2.* (transferase) inhibitor @@ -18746,6 +35306,24 @@ synonym: "transferase inhibitors" RELATED [ChEBI] xref: Wikipedia:Transferase is_a: CHEBI:23924 ! enzyme inhibitor +[Term] +id: CHEBI:71365 +name: rifampicin zwitterion +namespace: chebi_ontology +def: "A zwitterion obtained by transfer of a proton from the 5-hydroxy group to the tertiary amino group of rifampicin." [] +subset: 3_STAR +synonym: "(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-acetoxy-6,9,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-4-ium-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-5-olate" EXACT IUPAC_NAME [IUPAC] +synonym: "rifampicin" RELATED [UniProt] +is_a: CHEBI:27369 ! zwitterion +relationship: is_tautomer_of CHEBI:28077 ! rifampicin +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C43H58N4O12" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JQXXHWHPUNPDRT-WLSIYKJHSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "822.94020" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "822.40512" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c([O-])c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\\C=N\\N1CC[NH+](C)CC1)c(O)c4c3C2=O" xsd:string + [Term] id: CHEBI:71406 name: (R)-adrenaline(1+) @@ -18770,6 +35348,123 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "184.21240" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "184.09682" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+]C[C@H](O)c1ccc(O)c(O)c1" xsd:string +[Term] +id: CHEBI:71415 +name: nitrofurantoin +namespace: chebi_ontology +alt_id: CHEBI:7591 +def: "An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA." [] +subset: 3_STAR +synonym: "1-((5-Nitrofurfurylidene)amino)hydantoin" RELATED [ChemIDplus] +synonym: "1-(5-Nitro-2-furfurylidenamino)hydantoin" RELATED [ChemIDplus] +synonym: "1-(5-Nitro-2-furfurylideneamino)hydantoin" RELATED [ChemIDplus] +synonym: "1-[(5-Nitrofurfurylidene)amino]hydantoin" RELATED [NIST_Chemistry_WebBook] +synonym: "1-{[(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "5-Nitrofurantoin" RELATED [NIST_Chemistry_WebBook] +synonym: "N-(5-Nitrofurfurylidene)-1-aminohydantoin" RELATED [ChemIDplus] +synonym: "nitrofurantoin" RELATED INN [KEGG_DRUG] +synonym: "nitrofurantoina" RELATED INN [ChemIDplus] +synonym: "nitrofurantoine" RELATED INN [ChemIDplus] +synonym: "nitrofurantoinum" RELATED INN [ChemIDplus] +xref: CAS:67-20-9 {source="KEGG COMPOUND"} +xref: CAS:67-20-9 {source="ChemIDplus"} +xref: CAS:67-20-9 {source="NIST Chemistry WebBook"} +xref: Drug_Central:1949 {source="DrugCentral"} +xref: DrugBank:DB00698 +xref: KEGG:C07268 +xref: KEGG:D00439 +xref: Patent:US2610181 +xref: Patent:US2898335 +xref: Patent:US2927110 +xref: Patent:WO2006019844 +xref: Patent:WO2008103673 +xref: Patent:WO2010065110 +xref: PMID:21567157 {source="Europe PMC"} +xref: PMID:22240115 {source="Europe PMC"} +xref: PMID:22252772 {source="Europe PMC"} +xref: PMID:22252808 {source="Europe PMC"} +xref: PMID:22285235 {source="Europe PMC"} +xref: PMID:22332195 {source="Europe PMC"} +xref: PMID:22508296 {source="Europe PMC"} +xref: PMID:22535452 {source="Europe PMC"} +xref: PMID:22552451 {source="Europe PMC"} +xref: PMID:22722224 {source="Europe PMC"} +xref: PMID:22779302 {source="Europe PMC"} +xref: PMID:22787489 {source="Europe PMC"} +xref: PMID:22836745 {source="Europe PMC"} +xref: PMID:22857139 {source="Europe PMC"} +xref: PMID:22869929 {source="Europe PMC"} +xref: PMID:22876623 {source="Europe PMC"} +xref: PMID:22923965 {source="Europe PMC"} +xref: PMID:22929632 {source="Europe PMC"} +xref: PMID:22977056 {source="Europe PMC"} +xref: PMID:23016316 {source="Europe PMC"} +xref: PMID:23109011 {source="Europe PMC"} +xref: PMID:23113731 {source="Europe PMC"} +xref: PMID:23114172 {source="Europe PMC"} +xref: Reaxys:8132135 {source="Reaxys"} +xref: Wikipedia:Nitrofurantoin +is_a: CHEBI:24628 ! imidazolidine-2,4-dione +is_a: CHEBI:87230 ! nitrofuran antibiotic +relationship: has_functional_parent CHEBI:28306 ! semicarbazide +relationship: has_role CHEBI:36047 ! antibacterial drug +relationship: has_role CHEBI:50908 ! hepatotoxic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H6N4O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NXFQHRVNIOXGAQ-YCRREMRBSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "238.157" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "238.03382" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(N(/N=C/C=2OC(=CC2)[N+]([O-])=O)CC(N1)=O)=O" xsd:string + +[Term] +id: CHEBI:71418 +name: triamcinolone acetonide +namespace: chebi_ontology +alt_id: CHEBI:9668 +def: "A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections." [] +subset: 3_STAR +synonym: "(11beta,16alpha)-9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione" RELATED [NIST_Chemistry_WebBook] +synonym: "(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide" RELATED [NIST_Chemistry_WebBook] +synonym: "9alpha-fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene,3,20-dione" RELATED [NIST_Chemistry_WebBook] +synonym: "9alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione" RELATED [ChemIDplus] +synonym: "9alpha-fluoro-16alpha-17alpha-isopropyledenedioxyprednisolone" RELATED [ChemIDplus] +synonym: "9alpha-fluoro-16alpha-17alpha-isopropylidenedioxy-Delta-1-hydrocortisone" RELATED [ChemIDplus] +synonym: "9alpha-fluoro-16alpha-hydroxyprednisolone 16alpha,17alpha-acetonide" RELATED [ChemIDplus] +synonym: "Triamcinolone 16,17-acetonide" RELATED [ChemIDplus] +synonym: "triamcinolone acetonide" EXACT [UniProt] +xref: CAS:76-25-5 {source="KEGG COMPOUND"} +xref: CAS:76-25-5 {source="ChemIDplus"} +xref: Drug_Central:2726 {source="DrugCentral"} +xref: DrugBank:DB00620 +xref: KEGG:C08183 +xref: KEGG:D00983 +xref: Patent:US2008118586 +xref: Patent:US2008139545 +xref: Reaxys:60069 {source="Reaxys"} +xref: VSDB:3009 +xref: Wikipedia:Triamcinolone_acetonide +is_a: CHEBI:139590 ! primary alpha-hydroxy ketone +is_a: CHEBI:24261 ! glucocorticoid +is_a: CHEBI:35344 ! 21-hydroxy steroid +is_a: CHEBI:35346 ! 11beta-hydroxy steroid +is_a: CHEBI:36885 ! 20-oxo steroid +is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid +is_a: CHEBI:50830 ! fluorinated steroid +is_a: CHEBI:59779 ! cyclic ketal +relationship: has_functional_parent CHEBI:9667 ! triamcinolone +relationship: has_parent_hydride CHEBI:8386 ! pregnane +relationship: has_role CHEBI:35472 ! anti-inflammatory drug +relationship: has_role CHEBI:50857 ! anti-allergic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H31FO6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YNDXUCZADRHECN-JNQJZLCISA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "434.49770" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "434.21047" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C" xsd:string + [Term] id: CHEBI:71666 name: gamma-amino acid anion @@ -18780,6 +35475,93 @@ synonym: "gamma-amino acid anions" RELATED [ChEBI] is_a: CHEBI:37022 ! amino-acid anion relationship: is_conjugate_base_of CHEBI:33707 ! gamma-amino acid +[Term] +id: CHEBI:72564 +name: temozolomide +namespace: chebi_ontology +def: "An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma." [] +subset: 3_STAR +synonym: "3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide" RELATED [ChemIDplus] +synonym: "3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide" RELATED [ChemIDplus] +synonym: "3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide" RELATED [ChemIDplus] +synonym: "3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one" RELATED [ChemIDplus] +synonym: "BRN 5547136" RELATED [ChemIDplus] +synonym: "CCRG 81045" RELATED [ChemIDplus] +synonym: "CCRG-81045" RELATED [ChemIDplus] +synonym: "CCRIS 8996" RELATED [ChemIDplus] +synonym: "M & B 39831" RELATED [ChemIDplus] +synonym: "M&B 39831" RELATED [ChemIDplus] +synonym: "MB 39831" RELATED [ChemIDplus] +synonym: "methazolastone" RELATED [ChemIDplus] +synonym: "NSC 362856" RELATED [ChemIDplus] +synonym: "Sch 52365" RELATED [ChemIDplus] +synonym: "Temodal" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Temodar" RELATED BRAND_NAME [ChEBI] +synonym: "temozolomida" RELATED INN [WHO_MedNet] +synonym: "temozolomide" RELATED INN [ChemIDplus] +synonym: "temozolomide" RELATED INN [WHO_MedNet] +synonym: "temozolomidum" RELATED INN [WHO_MedNet] +synonym: "TMZ" RELATED [ChEBI] +xref: CAS:85622-93-1 {source="ChemIDplus"} +xref: Drug_Central:2589 {source="DrugCentral"} +xref: DrugBank:DB00853 +xref: HMDB:HMDB0014991 +xref: KEGG:D06067 +xref: LINCS:LSM-4590 +xref: Patent:DE3231255 +xref: PMID:22680781 {source="Europe PMC"} +xref: PMID:22818211 {source="Europe PMC"} +xref: PMID:23246370 {source="Europe PMC"} +xref: PMID:23254891 {source="Europe PMC"} +xref: PMID:23293540 {source="Europe PMC"} +xref: PMID:23335050 {source="Europe PMC"} +xref: PMID:23362460 {source="Europe PMC"} +xref: PMID:23377829 {source="Europe PMC"} +xref: PMID:23385995 {source="Europe PMC"} +xref: PMID:23389760 {source="Europe PMC"} +xref: Reaxys:5547136 {source="Reaxys"} +xref: Wikipedia:Temozolomide +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:72565 ! imidazotetrazine +is_a: CHEBI:72573 ! triazene derivative +relationship: has_role CHEBI:22333 ! alkylating agent +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:50266 ! prodrug +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H6N6O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BPEGJWRSRHCHSN-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "194.15080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "194.05522" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cn1nnc2c(ncn2c1=O)C(N)=O" xsd:string + +[Term] +id: CHEBI:72565 +name: imidazotetrazine +namespace: chebi_ontology +def: "Any organic heterobicyclic compound containing ortho-fused imidazole and tetrazine rings." [] +subset: 3_STAR +synonym: "imidazotetrazines" RELATED [ChEBI] +is_a: CHEBI:27171 ! organic heterobicyclic compound +is_a: CHEBI:38101 ! organonitrogen heterocyclic compound + +[Term] +id: CHEBI:72573 +name: triazene derivative +namespace: chebi_ontology +def: "A nitrogen molecular entity resulting from the formal substitution of one or more of the hydrogens of triazene." [] +subset: 3_STAR +synonym: "triazene derivatives" RELATED [ChEBI] +synonym: "triazenes" RELATED [ChEBI] +is_a: CHEBI:51143 ! nitrogen molecular entity +relationship: has_parent_hydride CHEBI:35468 ! triazene +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "N3R3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "42.020" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "42.00922" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]N=NN([*])[*]" xsd:string + [Term] id: CHEBI:72587 name: (R)-noradrenaline(1+) @@ -18803,6 +35585,22 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "170.187" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "170.08117" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1(C=CC(=CC1O)[C@H](C[NH3+])O)O" xsd:string +[Term] +id: CHEBI:72588 +name: semisynthetic derivative +namespace: chebi_ontology +def: "Any organic molecular entity derived from a natural product by partial chemical synthesis." [] +subset: 3_STAR +synonym: "semi-synthetic compound" RELATED [ChEBI] +synonym: "semi-synthetic compounds" RELATED [ChEBI] +synonym: "semi-synthetic derivative" RELATED [ChEBI] +synonym: "semi-synthetic derivatives" RELATED [ChEBI] +synonym: "semisynthetic compound" RELATED [ChEBI] +synonym: "semisynthetic compounds" RELATED [ChEBI] +synonym: "semisynthetic derivatives" RELATED [ChEBI] +xref: Wikipedia:Semisynthesis +is_a: CHEBI:50860 ! organic molecular entity + [Term] id: CHEBI:72695 name: organic molecule @@ -18815,6 +35613,42 @@ synonym: "organic molecules" RELATED [ChEBI] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity +[Term] +id: CHEBI:72773 +name: carotogenesis inhibitor +namespace: chebi_ontology +def: "Any inhibitor of the biosynthesis of carotenoids." [] +subset: 3_STAR +synonym: "carotogenesis inhibitors" RELATED [ChEBI] +is_a: CHEBI:35222 ! inhibitor + +[Term] +id: CHEBI:72774 +name: EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor +namespace: chebi_ontology +def: "An EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitor that interferes with the action of phytoene desaturase (zeta-carotene-forming), EC 1.3.99.29, an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene (zeta-carotene) via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene." [] +subset: 3_STAR +synonym: "15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitor" RELATED [ChEBI] +synonym: "15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitors" RELATED [ChEBI] +synonym: "2-step phytoene desaturase inhibitor" RELATED [ChEBI] +synonym: "2-step phytoene desaturase inhibitors" RELATED [ChEBI] +synonym: "CrtIa inhibitor" RELATED [ChEBI] +synonym: "CrtIa inhibitors" RELATED [ChEBI] +synonym: "EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitors" RELATED [ChEBI] +synonym: "EC 1.3.99.29 inhibitor" RELATED [ChEBI] +synonym: "EC 1.3.99.29 inhibitors" RELATED [ChEBI] +synonym: "phytoene dehydrogenase inhibitor" RELATED [ChEBI] +synonym: "phytoene dehydrogenase inhibitors" RELATED [ChEBI] +synonym: "phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitor" RELATED [ChEBI] +synonym: "phytoene desaturase (zeta-carotene-forming) (EC 1.3.99.29) inhibitors" RELATED [ChEBI] +synonym: "phytoene desaturase (zeta-carotene-forming) inhibitor" RELATED [ChEBI] +synonym: "phytoene desaturase (zeta-carotene-forming) inhibitors" RELATED [ChEBI] +synonym: "phytoene desaturase inhibitor" RELATED [ChEBI] +synonym: "phytoene desaturase inhibitors" RELATED [ChEBI] +synonym: "two-step phytoene desaturase inhibitor" RELATED [ChEBI] +synonym: "two-step phytoene desaturase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76859 ! EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor + [Term] id: CHEBI:72813 name: exopolysaccharide @@ -18842,6 +35676,80 @@ xref: Wikipedia:Exopolysaccharide xref: Wikipedia:Extracellular_polymeric_substance is_a: CHEBI:33694 ! biomacromolecule +[Term] +id: CHEBI:73181 +name: EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor +namespace: chebi_ontology +def: "An EC 1.11.1.* (peroxidases) inhibitor that inhibits the action of L-ascorbate peroxidase (EC 1.11.1.11)." [] +subset: 3_STAR +synonym: "ascorbate peroxidase inhibitor" RELATED [ChEBI] +synonym: "ascorbate peroxidase inhibitors" RELATED [ChEBI] +synonym: "ascorbic acid peroxidase inhibitor" RELATED [ChEBI] +synonym: "ascorbic acid peroxidase inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.1.11 inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.1.11 inhibitors" RELATED [ChEBI] +synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitor" RELATED [ChEBI] +synonym: "L-ascorbate peroxidase (EC 1.11.1.11) inhibitors" RELATED [ChEBI] +synonym: "L-ascorbate peroxidase inhibitor" RELATED [ChEBI] +synonym: "L-ascorbate peroxidase inhibitors" RELATED [ChEBI] +synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "L-ascorbic acid peroxidase inhibitor" RELATED [ChEBI] +synonym: "L-ascorbic acid peroxidase inhibitors" RELATED [ChEBI] +synonym: "L-ascorbic acid-specific peroxidase inhibitor" RELATED [ChEBI] +synonym: "L-ascorbic acid-specific peroxidase inhibitors" RELATED [ChEBI] +xref: Wikipedia:L-ascorbate_peroxidase +is_a: CHEBI:75381 ! EC 1.11.1.* (peroxidases) inhibitor + +[Term] +id: CHEBI:73182 +name: plant activator +namespace: chebi_ontology +def: "Any compound that protects plants by activating their defence mechanisms." [] +subset: 3_STAR +synonym: "plant activators" RELATED [ChEBI] +is_a: CHEBI:33286 ! agrochemical + +[Term] +id: CHEBI:73216 +name: EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:76765 +def: "Any hydrolase inhibitor that interferes with the action of a hydrolase which acts on acid anhydrides (EC 3.6.*.*)." [] +subset: 3_STAR +synonym: "acid anhydride hydrolase inhibitor" RELATED [ChEBI] +synonym: "acid anhydride hydrolase inhibitors" RELATED [ChEBI] +synonym: "EC 3.6 inhibitor" RELATED [ChEBI] +synonym: "EC 3.6 inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.6.* inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.*.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.6.*.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] +synonym: "inhibitors of hydrolase acting on acid anhydride (EC 3.6.*)" RELATED [ChEBI] +is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor + +[Term] +id: CHEBI:73263 +name: cyclooxygenase 3 inhibitor +namespace: chebi_ontology +def: "A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 3." [] +subset: 3_STAR +synonym: "COX-3 inhibitor" RELATED [ChEBI] +synonym: "COX-3 inhibitors" RELATED [ChEBI] +synonym: "cyclo-oxygenase 3 inhibitor" RELATED [ChEBI] +synonym: "cyclo-oxygenase 3 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase 3 inhibitors" RELATED [ChEBI] +synonym: "cyclooxygenase-3 inhibitor" RELATED [ChEBI] +synonym: "cyclooxygenase-3 inhibitors" RELATED [ChEBI] +xref: PMID:12242329 {source="Europe PMC"} +xref: PMID:12374850 {source="Europe PMC"} +xref: PMID:14592546 {source="Europe PMC"} +xref: Wikipedia:COX-3 +is_a: CHEBI:35544 ! EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor + [Term] id: CHEBI:73398 name: indole skeleton @@ -18855,6 +35763,42 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "110.09230" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "110.00307" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C2C(=C1*)N(C(=C2*)*)*)*)*)*" xsd:string +[Term] +id: CHEBI:73474 +name: acetylenic compound +namespace: chebi_ontology +def: "Any organic molecule containing a C#C bond." [] +subset: 3_STAR +synonym: "acetylenic compounds" RELATED [ChEBI] +synonym: "C#C containing compound" RELATED [ChEBI] +synonym: "C#C containing compounds" RELATED [ChEBI] +synonym: "C#C-containing compound" RELATED [ChEBI] +synonym: "C#C-containing compounds" RELATED [ChEBI] +is_a: CHEBI:72695 ! organic molecule +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2R2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "24.021" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "24.00000" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C#C[*]" xsd:string + +[Term] +id: CHEBI:73477 +name: terminal acetylenic compound +namespace: chebi_ontology +def: "An acetylenic compound which a carbon of the C#C moiety is attached to a hydrogen atom." [] +subset: 3_STAR +synonym: "C#C-H containing compound" RELATED [ChEBI] +synonym: "C#C-H containing compounds" RELATED [ChEBI] +synonym: "C#CH containing compound" RELATED [ChEBI] +synonym: "C#CH containing compounds" RELATED [ChEBI] +synonym: "terminal acetylenic compounds" RELATED [ChEBI] +is_a: CHEBI:73474 ! acetylenic compound +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2HR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "25.029" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "25.00783" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]C#C[*]" xsd:string + [Term] id: CHEBI:73541 name: organic heterobicyclic ring @@ -18864,6 +35808,125 @@ subset: 3_STAR synonym: "organic heterobicyclic rings" RELATED [ChEBI] is_a: CHEBI:52845 ! cyclic organic group +[Term] +id: CHEBI:73690 +name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid +namespace: chebi_ontology +def: "An L-alpha-amino acid which is biosynthesised from erythrose 4-phosphate and phosphoenolpyruvate (i.e. phenylalanine, tyrosine, and tryptophan). A closed class." [] +subset: 3_STAR +synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acid" RELATED [ChEBI] +synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acids" RELATED [ChEBI] +synonym: "erythrose 4-phosphate family amino acid" RELATED [ChEBI] +synonym: "erythrose 4-phosphate family amino acids" RELATED [ChEBI] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acids" RELATED [ChEBI] +synonym: "phosphoenolpyruvate family amino acid" RELATED [ChEBI] +synonym: "phosphoenolpyruvate family amino acids" RELATED [ChEBI] +is_a: CHEBI:15705 ! L-alpha-amino acid +is_a: CHEBI:83813 ! proteinogenic amino acid + +[Term] +id: CHEBI:73913 +name: antifolate +namespace: chebi_ontology +def: "An antimetabolite that impairs the action of folic acids" [] +subset: 3_STAR +synonym: "antifolates" RELATED [ChEBI] +synonym: "folic acid antagonist" RELATED [ChEBI] +synonym: "folic acid antagonists" RELATED [ChEBI] +xref: Wikipedia:Antifolate +is_a: CHEBI:35221 ! antimetabolite + +[Term] +id: CHEBI:74213 +name: EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor +namespace: chebi_ontology +def: "An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1)." [] +subset: 3_STAR +synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "ADP reductase inhibitor" RELATED [ChEBI] +synonym: "ADP reductase inhibitors" RELATED [ChEBI] +synonym: "CDP reductase inhibitor" RELATED [ChEBI] +synonym: "CDP reductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.4.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.17.4.1 inhibitors" RELATED [ChEBI] +synonym: "nucleoside diphosphate reductase inhibitor" RELATED [ChEBI] +synonym: "nucleoside diphosphate reductase inhibitors" RELATED [ChEBI] +synonym: "ribonucleoside diphosphate reductase inhibitor" RELATED [ChEBI] +synonym: "ribonucleoside diphosphate reductase inhibitors" RELATED [ChEBI] +synonym: "ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor" RELATED [ChEBI] +synonym: "ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitors" RELATED [ChEBI] +synonym: "ribonucleoside-diphosphate reductase inhibitor" RELATED [ChEBI] +synonym: "ribonucleoside-diphosphate reductase inhibitors" RELATED [ChEBI] +synonym: "ribonucleotide diphosphate reductase inhibitor" RELATED [ChEBI] +synonym: "ribonucleotide diphosphate reductase inhibitors" RELATED [ChEBI] +synonym: "ribonucleotide reductase inhibitor" RELATED [ChEBI] +synonym: "ribonucleotide reductase inhibitors" RELATED [ChEBI] +synonym: "RR inhibitor" RELATED [ChEBI] +synonym: "RR inhibitors" RELATED [ChEBI] +synonym: "UDP reductase inhibitor" RELATED [ChEBI] +synonym: "UDP reductase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Ribonucleoside-diphosphate_reductase +is_a: CHEBI:76848 ! EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor + +[Term] +id: CHEBI:74222 +name: gamma-lactam +namespace: chebi_ontology +def: "A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon." [] +subset: 3_STAR +synonym: "gamma-lactams" RELATED [ChEBI] +is_a: CHEBI:24995 ! lactam + +[Term] +id: CHEBI:74422 +name: 4'-demethylepipodophyllotoxin +namespace: chebi_ontology +def: "An organic heterotetracyclic compound that is the 9- epimer of 4'-demethylpodophyllotoxin." [] +subset: 3_STAR +synonym: "(-)-4'-demethylepipodophyllotoxin" RELATED [ChEBI] +synonym: "(5R,5aR,8aR,9S)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one" EXACT IUPAC_NAME [IUPAC] +synonym: "4'-demethyl-9-epipodophyllotoxin" RELATED [ChEBI] +synonym: "4'-demethylepipodophyllotoxin" EXACT [UniProt] +synonym: "4'-O-demethyl-4-epipodophyllotoxin" RELATED [ChEBI] +synonym: "4'-O-demethylepipodophyllotoxin" RELATED [ChEBI] +synonym: "DMEP" RELATED [ChEBI] +synonym: "epi-4'-demethylpodophyllotoxin" RELATED [ChEBI] +xref: CAS:6559-91-7 {source="ChemIDplus"} +xref: PMID:15246103 {source="Europe PMC"} +xref: PMID:19396467 {source="Europe PMC"} +xref: PMID:21398491 {source="Europe PMC"} +xref: PMID:21706170 {source="Europe PMC"} +xref: Reaxys:1358259 {source="Reaxys"} +is_a: CHEBI:33853 ! phenols +is_a: CHEBI:50307 ! furonaphthodioxole +relationship: has_role CHEBI:35610 ! antineoplastic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H20O8" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YVCVYCSAAZQOJI-JHQYFNNDSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "400.37870" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "400.11582" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O" xsd:string + +[Term] +id: CHEBI:74440 +name: epidermal growth factor receptor antagonist +namespace: chebi_ontology +def: "An antagonist at the epidermal growth factor receptor." [] +subset: 3_STAR +synonym: "EGFR antagonoist" RELATED [ChEBI] +synonym: "EGFR antagonoists" RELATED [ChEBI] +synonym: "EGFR inhibitor" RELATED [ChEBI] +synonym: "EGFR inhibitors" RELATED [ChEBI] +synonym: "epidermal growth factor receptor antagonists" RELATED [ChEBI] +synonym: "epidermal growth factor receptor inhibitor" RELATED [ChEBI] +synonym: "epidermal growth factor receptor inhibitors" RELATED [ChEBI] +xref: Wikipedia:Epidermal_growth_factor_receptor +is_a: CHEBI:37699 ! protein kinase inhibitor +is_a: CHEBI:48706 ! antagonist + [Term] id: CHEBI:74783 name: astringent @@ -18876,6 +35939,110 @@ synonym: "astringents" RELATED [ChEBI] xref: Wikipedia:Astringent is_a: CHEBI:23888 ! drug +[Term] +id: CHEBI:75045 +name: dabrafenib +namespace: chebi_ontology +def: "An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma." [] +subset: 3_STAR +synonym: "dabrafenib" RELATED INN [ChemIDplus] +synonym: "N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] +xref: CAS:1195765-45-7 {source="ChemIDplus"} +xref: Drug_Central:4801 {source="DrugCentral"} +xref: KEGG:D10064 +xref: LINCS:LSM-6303 +xref: Patent:WO2011047238 +xref: PMID:22981500 {source="Europe PMC"} +xref: PMID:23237741 {source="Europe PMC"} +xref: PMID:23249624 {source="Europe PMC"} +xref: PMID:23276366 {source="Europe PMC"} +xref: PMID:23290787 {source="Europe PMC"} +xref: PMID:23317446 {source="Europe PMC"} +xref: PMID:23403819 {source="Europe PMC"} +xref: PMID:23463215 {source="Europe PMC"} +xref: PMID:23470635 {source="Europe PMC"} +xref: PMID:23515890 {source="Europe PMC"} +xref: PMID:23537694 {source="Europe PMC"} +xref: PMID:23552670 {source="Europe PMC"} +xref: PMID:23608920 {source="Europe PMC"} +xref: PMID:23617957 {source="Europe PMC"} +xref: PMID:23621583 {source="Europe PMC"} +xref: PMID:23656699 {source="Europe PMC"} +xref: PMID:23709751 {source="Europe PMC"} +xref: PMID:23714462 {source="Europe PMC"} +xref: PMID:23795808 {source="Europe PMC"} +xref: PMID:23807941 {source="Europe PMC"} +xref: PMID:23833299 {source="Europe PMC"} +xref: PMID:23844038 {source="Europe PMC"} +xref: PMID:23846776 {source="Europe PMC"} +xref: PMID:23870055 {source="Europe PMC"} +xref: PMID:23881668 {source="Europe PMC"} +xref: Reaxys:19689971 {source="Reaxys"} +xref: Wikipedia:Dabrafenib +is_a: CHEBI:35358 ! sulfonamide +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:38338 ! aminopyrimidine +is_a: CHEBI:38418 ! 1,3-thiazoles +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:75047 ! B-Raf inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H20F3N5O2S2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BFSMGDJOXZAERB-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "519.56200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "519.10105" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1" xsd:string + +[Term] +id: CHEBI:75047 +name: B-Raf inhibitor +namespace: chebi_ontology +def: "A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)" [] +subset: 3_STAR +synonym: "B-Raf inhibitors" RELATED [ChEBI] +synonym: "BRAF inhibitor" RELATED [ChEBI] +synonym: "BRAF inhibitors" RELATED [ChEBI] +synonym: "human mutant serine/threonine kinase inhibitor" RELATED [ChEBI] +synonym: "human mutant serine/threonine kinase inhibitors" RELATED [ChEBI] +is_a: CHEBI:50925 ! EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor + +[Term] +id: CHEBI:75381 +name: EC 1.11.1.* (peroxidases) inhibitor +namespace: chebi_ontology +def: "An EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor that interferes with the action of any of the peroxidases (EC 1.11.1.*)." [] +subset: 3_STAR +synonym: "EC 1.11.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.1 inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.1.* (peroxidase) inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.1.* (peroxidase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.1.* (peroxidases) inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.1.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of peroxidases" RELATED [ChEBI] +synonym: "inhibitors of peroxidases" RELATED [ChEBI] +synonym: "peroxidases inhibitors" RELATED [ChEBI] +xref: Wikipedia:Peroxidases +is_a: CHEBI:76738 ! EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor + +[Term] +id: CHEBI:75596 +name: EC 5.* (isomerase) inhibitor +namespace: chebi_ontology +def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." [] +subset: 3_STAR +synonym: "EC 5.* (isomerase) inhibitors" RELATED [ChEBI] +synonym: "EC 5.* inhibitor" RELATED [ChEBI] +synonym: "EC 5.* inhibitors" RELATED [ChEBI] +synonym: "EC 5.*.*.* inhibitor" RELATED [ChEBI] +synonym: "EC 5.*.*.* inhibitors" RELATED [ChEBI] +synonym: "isomerase (EC 5.*) inhibitor" RELATED [ChEBI] +synonym: "isomerase (EC 5.*) inhibitors" RELATED [ChEBI] +synonym: "isomerase inhibitor" RELATED [ChEBI] +synonym: "isomerase inhibitors" RELATED [ChEBI] +is_a: CHEBI:23924 ! enzyme inhibitor + [Term] id: CHEBI:75600 name: EC 6.3.* (C-N bond-forming ligase) inhibitor @@ -18911,6 +36078,25 @@ synonym: "ligase inhibitors" RELATED [ChEBI] xref: Wikipedia:Ligase is_a: CHEBI:23924 ! enzyme inhibitor +[Term] +id: CHEBI:75604 +name: EC 6.4.* (C-C bond-forming ligase) inhibitor +namespace: chebi_ontology +def: "A ligase inhibitor that interferes with the action of a C-C bond-forming ligase (EC 6.4.*.*)." [] +subset: 3_STAR +synonym: "C--C bond-forming ligase inhibitor" RELATED [ChEBI] +synonym: "C--C bond-forming ligase inhibitors" RELATED [ChEBI] +synonym: "C-C bond-forming ligase (EC 6.4.*) inhibitor" RELATED [ChEBI] +synonym: "C-C bond-forming ligase (EC 6.4.*) inhibitorS" RELATED [ChEBI] +synonym: "C-C bond-forming ligase inhibitor" RELATED [ChEBI] +synonym: "C-C bond-forming ligase inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.* (C-C bond-forming ligase) inhibitorS" RELATED [ChEBI] +synonym: "EC 6.4.* inhibitor" RELATED [ChEBI] +synonym: "EC 6.4.* inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.*.* inhibitor" RELATED [ChEBI] +synonym: "EC 6.4.*.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:75603 ! EC 6.* (ligase) inhibitor + [Term] id: CHEBI:75763 name: eukaryotic metabolite @@ -18947,6 +36133,7 @@ id: CHEBI:75769 name: B vitamin namespace: chebi_ontology def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." [] +def: "Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such)." [] subset: 3_STAR synonym: "B vitamins" RELATED [ChEBI] synonym: "B-group vitamin" RELATED [ChEBI] @@ -18962,7 +36149,7 @@ xref: PMID:23690582 {source="Europe PMC"} xref: Wikipedia:B_vitamin is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound -relationship: has_role CHEBI:27314 ! water-soluble vitamin (role) +relationship: has_role CHEBI:27314 ! water-soluble vitamin relationship: has_role CHEBI:50733 ! nutraceutical [Term] @@ -19005,6 +36192,234 @@ subset: 3_STAR synonym: "prokaryotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite +[Term] +id: CHEBI:75885 +name: 2-pyranones +namespace: chebi_ontology +def: "A pyranone based on the structure of 2H-pyran-2-one and its substituted derivatives." [] +subset: 3_STAR +synonym: "2-oxo-2H-pyrans" RELATED [ChEBI] +synonym: "2-pyrones" RELATED [ChEBI] +synonym: "2H-pyran-2-ones" RELATED [ChEBI] +synonym: "alpha-pyrones" RELATED [ChEBI] +synonym: "pyran-2-ones" RELATED [ChEBI] +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:37963 ! pyranone + +[Term] +id: CHEBI:75954 +name: vancomycin aglycone zwitterion +namespace: chebi_ontology +def: "A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino group of vancomycin aglycone." [] +subset: 3_STAR +xref: MetaCyc:CPD-15745 {source="SUBMITTER"} +xref: PMID:11470430 {source="SUBMITTER"} +is_a: CHEBI:60466 ! peptide zwitterion +relationship: is_conjugate_acid_of CHEBI:77981 ! vancomycin aglycone(1-) +relationship: is_tautomer_of CHEBI:47724 ! vancomycin aglycone +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H52Cl2N8O17" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1143.92900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1142.28275" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3O)c(Cl)c2" xsd:string + +[Term] +id: CHEBI:75998 +name: trametinib +namespace: chebi_ontology +def: "A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment." [] +subset: 3_STAR +synonym: "GSK 1120212" RELATED [ChemIDplus] +synonym: "JTP 74057" RELATED [ChemIDplus] +synonym: "N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide" EXACT IUPAC_NAME [IUPAC] +synonym: "trametinib" RELATED INN [WHO_MedNet] +synonym: "trametinibum" RELATED INN [WHO_MedNet] +xref: CAS:871700-17-3 {source="KEGG COMPOUND"} +xref: CAS:871700-17-3 {source="ChemIDplus"} +xref: Chemspider:9881833 +xref: Drug_Central:4802 {source="DrugCentral"} +xref: DrugBank:DB08911 +xref: KEGG:D10175 +xref: LINCS:LSM-1143 +xref: Patent:WO2005121142 +xref: Patent:WO2011038082 +xref: Patent:WO2011038085 +xref: Patent:WO2011047238 +xref: PMCID:PMC7715110 {source="Europe PMC"} +xref: PMID:21523318 {source="Europe PMC"} +xref: PMID:22245957 {source="Europe PMC"} +xref: PMID:23035153 {source="Europe PMC"} +xref: PMID:23237773 {source="Europe PMC"} +xref: PMID:23248257 {source="Europe PMC"} +xref: PMID:23290787 {source="Europe PMC"} +xref: PMID:23432625 {source="Europe PMC"} +xref: PMID:23438367 {source="Europe PMC"} +xref: PMID:23441129 {source="Europe PMC"} +xref: PMID:23533766 {source="Europe PMC"} +xref: PMID:23583440 {source="Europe PMC"} +xref: PMID:23587417 {source="Europe PMC"} +xref: PMID:23649971 {source="Europe PMC"} +xref: PMID:23658559 {source="Europe PMC"} +xref: PMID:23709751 {source="Europe PMC"} +xref: PMID:23807941 {source="Europe PMC"} +xref: PMID:23844038 {source="Europe PMC"} +xref: PMID:23846731 {source="Europe PMC"} +xref: PMID:23893461 {source="Europe PMC"} +xref: PMID:23971497 {source="Europe PMC"} +xref: PMID:23977666 {source="Europe PMC"} +xref: PMID:24055054 {source="Europe PMC"} +xref: PMID:26119340 {source="Europe PMC"} +xref: PMID:33922284 {source="Europe PMC"} +xref: PMID:34034619 {source="Europe PMC"} +xref: PMID:34145930 {source="Europe PMC"} +xref: PMID:34156985 {source="Europe PMC"} +xref: PMID:34282746 {source="Europe PMC"} +xref: PMID:34355652 {source="Europe PMC"} +xref: PMID:34413035 {source="Europe PMC"} +xref: PMID:34421360 {source="Europe PMC"} +xref: PMID:34484797 {source="Europe PMC"} +xref: PMID:34516041 {source="Europe PMC"} +xref: PMID:34590600 {source="Europe PMC"} +xref: PMID:34592184 {source="Europe PMC"} +xref: Reaxys:12497153 {source="Reaxys"} +xref: Wikipedia:Trametinib +is_a: CHEBI:22160 ! acetamides +is_a: CHEBI:33860 ! aromatic amine +is_a: CHEBI:36820 ! ring assembly +is_a: CHEBI:37142 ! organoiodine compound +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:38932 ! pyridopyrimidine +is_a: CHEBI:51454 ! cyclopropanes +relationship: has_role CHEBI:149553 ! anticoronaviral agent +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:79091 ! EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C26H23FIN5O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LIRYPHYGHXZJBZ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "615.39480" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "615.07788" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O" xsd:string + +[Term] +id: CHEBI:76004 +name: dimethyl fumarate +namespace: chebi_ontology +def: "An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis." [] +subset: 3_STAR +synonym: "(E)-But-2-enedioic acid dimethyl ester" RELATED [NIST_Chemistry_WebBook] +synonym: "1,2-bis(methoxycarbonyl)-trans-ethylene" RELATED [HMDB] +synonym: "dimethyl (2E)-but-2-enedioate" EXACT IUPAC_NAME [IUPAC] +synonym: "Dimethyl trans-ethylenedicarboxylate" RELATED [ChemIDplus] +synonym: "Fumaric acid, dimethyl ester" RELATED [ChemIDplus] +synonym: "Tecfidera" RELATED [KEGG_DRUG] +synonym: "trans-1,2-Ethylenedicarboxylic acid dimethyl ester" RELATED [ChemIDplus] +synonym: "trans-Butenedioic acid dimethyl ester" RELATED [ChemIDplus] +xref: CAS:624-49-7 {source="KEGG DRUG"} +xref: CAS:624-49-7 {source="ChemIDplus"} +xref: CAS:624-49-7 {source="NIST Chemistry WebBook"} +xref: Drug_Central:4757 {source="DrugCentral"} +xref: DrugBank:DB08908 +xref: HMDB:HMDB0031257 +xref: KEGG:D03846 +xref: Patent:US2008089861 +xref: Patent:WO2011100589 +xref: PMID:23946617 {source="Europe PMC"} +xref: PMID:24061646 {source="Europe PMC"} +xref: PMID:24131282 {source="Europe PMC"} +xref: Reaxys:774590 {source="Reaxys"} +xref: Wikipedia:Dimethyl_fumarate +is_a: CHEBI:25248 ! methyl ester +is_a: CHEBI:51307 ! diester +is_a: CHEBI:51702 ! enoate ester +relationship: has_functional_parent CHEBI:18012 ! fumaric acid +relationship: has_role CHEBI:50748 ! antipsoriatic +relationship: has_role CHEBI:50846 ! immunomodulator +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H8O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "LDCRTTXIJACKKU-ONEGZZNKSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "144.12530" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "144.04226" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)\\C=C\\C(=O)OC" xsd:string + +[Term] +id: CHEBI:76010 +name: dolutegravir +namespace: chebi_ontology +def: "A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1." [] +subset: 3_STAR +synonym: "(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "S/GSK1349572" RELATED [ChemIDplus] +xref: CAS:1051375-16-6 {source="KEGG DRUG"} +xref: CAS:1051375-16-6 {source="ChemIDplus"} +xref: Drug_Central:4805 {source="DrugCentral"} +xref: KEGG:D10066 +xref: Patent:EP2602260 +xref: Patent:WO2006116764 +xref: PDBeChem:DLU +xref: PMID:22018760 {source="Europe PMC"} +xref: PMID:22205735 {source="Europe PMC"} +xref: PMID:22878423 {source="Europe PMC"} +xref: PMID:22905856 {source="Europe PMC"} +xref: PMID:23075918 {source="Europe PMC"} +xref: PMID:23132334 {source="Europe PMC"} +xref: PMID:23225901 {source="Europe PMC"} +xref: PMID:23295935 {source="Europe PMC"} +xref: PMID:23306000 {source="Europe PMC"} +xref: PMID:23413040 {source="Europe PMC"} +xref: PMID:23432922 {source="Europe PMC"} +xref: PMID:23455469 {source="Europe PMC"} +xref: PMID:23669385 {source="Europe PMC"} +xref: PMID:23777012 {source="Europe PMC"} +xref: PMID:23798668 {source="Europe PMC"} +xref: PMID:23807273 {source="Europe PMC"} +xref: PMID:23817375 {source="Europe PMC"} +xref: PMID:23824675 {source="Europe PMC"} +xref: PMID:23830355 {source="Europe PMC"} +xref: PMID:23845180 {source="Europe PMC"} +xref: PMID:23885999 {source="Europe PMC"} +xref: PMID:23942060 {source="Europe PMC"} +xref: PMID:24052331 {source="Europe PMC"} +xref: PMID:24074642 {source="Europe PMC"} +xref: PMID:24096683 {source="Europe PMC"} +xref: Reaxys:12732602 {source="Reaxys"} +xref: Wikipedia:Dolutegravir +is_a: CHEBI:140325 ! secondary carboxamide +is_a: CHEBI:26979 ! organic heterotricyclic compound +is_a: CHEBI:29347 ! monocarboxylic acid amide +is_a: CHEBI:38582 ! difluorobenzene +relationship: has_role CHEBI:67268 ! HIV-1 integrase inhibitor +relationship: is_conjugate_acid_of CHEBI:76014 ! dolutegravir(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H19F2N3O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RHWKPHLQXYSBKR-BMIGLBTASA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "419.37880" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "419.12928" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12" xsd:string + +[Term] +id: CHEBI:76014 +name: dolutegravir(1-) +namespace: chebi_ontology +def: "An organic anion that is the conjugate base of dolutegravir, obtained by deptotonation of the 7-hydroxy group." [] +subset: 3_STAR +synonym: "(4R,12aS)-9-[(2,4-difluorobenzyl)carbamoyl]-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate" EXACT IUPAC_NAME [IUPAC] +synonym: "dolutegravir anion" RELATED [ChEBI] +is_a: CHEBI:25696 ! organic anion +relationship: is_conjugate_base_of CHEBI:76010 ! dolutegravir +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H18F2N3O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/p-1/t10-,15+/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RHWKPHLQXYSBKR-BMIGLBTASA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "418.37080" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "418.12200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c([O-])c3C(=O)N12" xsd:string + [Term] id: CHEBI:76042 name: aromatic amino-acid zwitterion @@ -19031,6 +36446,17 @@ subset: 3_STAR synonym: "xenobiotic metabolites" RELATED [ChEBI] is_a: CHEBI:25212 ! metabolite +[Term] +id: CHEBI:76224 +name: aromatic ketone +namespace: chebi_ontology +def: "A ketone in which the carbonyl group is attached to an aromatic ring." [] +subset: 3_STAR +synonym: "aromatic ketones" RELATED [ChEBI] +synonym: "aryl ketone" RELATED [ChEBI] +synonym: "aryl ketones" RELATED [ChEBI] +is_a: CHEBI:17087 ! ketone + [Term] id: CHEBI:76413 name: greenhouse gas @@ -19094,6 +36520,207 @@ synonym: "triradylglycerols" RELATED [ChEBI] xref: LIPID_MAPS_class:LMGL0301 {source="SUBMITTER"} is_a: CHEBI:35741 ! glycerolipid +[Term] +id: CHEBI:76617 +name: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:66921 +def: "An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2)." [] +subset: 3_STAR +synonym: "ABL inhibitor" RELATED [ChEBI] +synonym: "ABL inhibitors" RELATED [ChEBI] +synonym: "ABL1 inhibitor" RELATED [ChEBI] +synonym: "ABL1 inhibitors" RELATED [ChEBI] +synonym: "ABL2 inhibitor" RELATED [ChEBI] +synonym: "ABL2 inhibitors" RELATED [ChEBI] +synonym: "ABLL inhibitor" RELATED [ChEBI] +synonym: "ABLL inhibitors" RELATED [ChEBI] +synonym: "ACK1 inhibitor" RELATED [ChEBI] +synonym: "ACK1 inhibitors" RELATED [ChEBI] +synonym: "ACK2 inhibitor" RELATED [ChEBI] +synonym: "ACK2 inhibitors" RELATED [ChEBI] +synonym: "AGMX1 inhibitor" RELATED [ChEBI] +synonym: "AGMX1 inhibitors" RELATED [ChEBI] +synonym: "ARG inhibitor" RELATED [ChEBI] +synonym: "ARG inhibitors" RELATED [ChEBI] +synonym: "ATK inhibitor" RELATED [ChEBI] +synonym: "ATK inhibitors" RELATED [ChEBI] +synonym: "ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitor" RELATED [ChEBI] +synonym: "ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) inhibitors" RELATED [ChEBI] +synonym: "BLK inhibitor" RELATED [ChEBI] +synonym: "BLK inhibitors" RELATED [ChEBI] +synonym: "Bmk inhibitor" RELATED [ChEBI] +synonym: "Bmk inhibitors" RELATED [ChEBI] +synonym: "BMX inhibitor" RELATED [ChEBI] +synonym: "BMX inhibitors" RELATED [ChEBI] +synonym: "BRK inhibitor" RELATED [ChEBI] +synonym: "BRK inhibitors" RELATED [ChEBI] +synonym: "Bruton's tyrosine kinase inhibitor" RELATED [ChEBI] +synonym: "Bruton's tyrosine kinase inhibitors" RELATED [ChEBI] +synonym: "Bsk inhibitor" RELATED [ChEBI] +synonym: "Bsk inhibitors" RELATED [ChEBI] +synonym: "BTK inhibitor" RELATED [ChEBI] +synonym: "BTK inhibitors" RELATED [ChEBI] +synonym: "BTKL inhibitor" RELATED [ChEBI] +synonym: "BTKL inhibitors" RELATED [ChEBI] +synonym: "CAKb inhibitor" RELATED [ChEBI] +synonym: "CAKb inhibitors" RELATED [ChEBI] +synonym: "Cdgip inhibitor" RELATED [ChEBI] +synonym: "Cdgip inhibitors" RELATED [ChEBI] +synonym: "CHK inhibitor" RELATED [ChEBI] +synonym: "CHK inhibitors" RELATED [ChEBI] +synonym: "CSK inhibitor" RELATED [ChEBI] +synonym: "CSK inhibitors" RELATED [ChEBI] +synonym: "CTK inhibitor" RELATED [ChEBI] +synonym: "CTK inhibitors" RELATED [ChEBI] +synonym: "CYL inhibitor" RELATED [ChEBI] +synonym: "CYL inhibitors" RELATED [ChEBI] +synonym: "cytoplasmic protein tyrosine kinase inhibitor" RELATED [ChEBI] +synonym: "cytoplasmic protein tyrosine kinase inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.10.2 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.10.2 inhibitors" RELATED [ChEBI] +synonym: "EMT inhibitor" RELATED [ChEBI] +synonym: "EMT inhibitors" RELATED [ChEBI] +synonym: "ETK inhibitor" RELATED [ChEBI] +synonym: "ETK inhibitors" RELATED [ChEBI] +synonym: "Fadk inhibitor" RELATED [ChEBI] +synonym: "Fadk inhibitors" RELATED [ChEBI] +synonym: "FAK inhibitor" RELATED [ChEBI] +synonym: "FAK inhibitors" RELATED [ChEBI] +synonym: "FAK2 inhibitor" RELATED [ChEBI] +synonym: "FAK2 inhibitors" RELATED [ChEBI] +synonym: "FER inhibitor" RELATED [ChEBI] +synonym: "FER inhibitors" RELATED [ChEBI] +synonym: "Fert1/2 inhibitor" RELATED [ChEBI] +synonym: "Fert1/2 inhibitors" RELATED [ChEBI] +synonym: "FES inhibitor" RELATED [ChEBI] +synonym: "FES inhibitors" RELATED [ChEBI] +synonym: "FGR inhibitor" RELATED [ChEBI] +synonym: "FGR inhibitors" RELATED [ChEBI] +synonym: "focal adhesion kinase inhibitor" RELATED [ChEBI] +synonym: "focal adhesion kinase inhibitors" RELATED [ChEBI] +synonym: "FPS inhibitor" RELATED [ChEBI] +synonym: "FPS inhibitors" RELATED [ChEBI] +synonym: "FRK inhibitor" RELATED [ChEBI] +synonym: "FRK inhibitors" RELATED [ChEBI] +synonym: "FYN inhibitor" RELATED [ChEBI] +synonym: "FYN inhibitors" RELATED [ChEBI] +synonym: "HCK inhibitor" RELATED [ChEBI] +synonym: "HCK inhibitors" RELATED [ChEBI] +synonym: "HCTK inhibitor" RELATED [ChEBI] +synonym: "HCTK inhibitors" RELATED [ChEBI] +synonym: "HYL inhibitor" RELATED [ChEBI] +synonym: "HYL inhibitors" RELATED [ChEBI] +synonym: "IMD1 inhibitor" RELATED [ChEBI] +synonym: "IMD1 inhibitors" RELATED [ChEBI] +synonym: "ITK inhibitor" RELATED [ChEBI] +synonym: "ITK inhibitors" RELATED [ChEBI] +synonym: "IYK inhibitor" RELATED [ChEBI] +synonym: "IYK inhibitors" RELATED [ChEBI] +synonym: "JAK1 inhibitor" RELATED [ChEBI] +synonym: "JAK1 inhibitors" RELATED [ChEBI] +synonym: "JAK2 inhibitor" RELATED [ChEBI] +synonym: "JAK2 inhibitors" RELATED [ChEBI] +synonym: "JAK3 inhibitor" RELATED [ChEBI] +synonym: "JAK3 inhibitors" RELATED [ChEBI] +synonym: "Janus kinase 1 inhibitor" RELATED [ChEBI] +synonym: "Janus kinase 1 inhibitors" RELATED [ChEBI] +synonym: "Janus kinase 2 inhibitor" RELATED [ChEBI] +synonym: "Janus kinase 2 inhibitors" RELATED [ChEBI] +synonym: "Janus kinase 3 inhibitor" RELATED [ChEBI] +synonym: "Janus kinase 3 inhibitors" RELATED [ChEBI] +synonym: "Janus kinase inhibitor" RELATED [ChEBI] +synonym: "JTK1 inhibitor" RELATED [ChEBI] +synonym: "JTK1 inhibitors" RELATED [ChEBI] +synonym: "JTK9 inhibitor" RELATED [ChEBI] +synonym: "JTK9 inhibitors" RELATED [ChEBI] +synonym: "L-JAK inhibitor" RELATED [ChEBI] +synonym: "L-JAK inhibitors" RELATED [ChEBI] +synonym: "LCK inhibitor" RELATED [ChEBI] +synonym: "LCK inhibitors" RELATED [ChEBI] +synonym: "LSK inhibitor" RELATED [ChEBI] +synonym: "LSK inhibitors" RELATED [ChEBI] +synonym: "LYN inhibitor" RELATED [ChEBI] +synonym: "LYN inhibitors" RELATED [ChEBI] +synonym: "MATK inhibitor" RELATED [ChEBI] +synonym: "MATK inhibitors" RELATED [ChEBI] +synonym: "non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitor" RELATED [ChEBI] +synonym: "non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitors" RELATED [ChEBI] +synonym: "Ntk inhibitor" RELATED [ChEBI] +synonym: "Ntk inhibitors" RELATED [ChEBI] +synonym: "p60c-src protein tyrosine kinase inhibitor" RELATED [ChEBI] +synonym: "p60c-src protein tyrosine kinase inhibitors" RELATED [ChEBI] +synonym: "PKB inhibitor" RELATED [ChEBI] +synonym: "PKB inhibitors" RELATED [ChEBI] +synonym: "PSCTK inhibitor" RELATED [ChEBI] +synonym: "PSCTK inhibitors" RELATED [ChEBI] +synonym: "PSCTK1 inhibitor" RELATED [ChEBI] +synonym: "PSCTK1 inhibitors" RELATED [ChEBI] +synonym: "PSCTK2 inhibitor" RELATED [ChEBI] +synonym: "PSCTK2 inhibitors" RELATED [ChEBI] +synonym: "PSCTK4 inhibitor" RELATED [ChEBI] +synonym: "PSCTK4 inhibitors" RELATED [ChEBI] +synonym: "PSCTK5 inhibitor" RELATED [ChEBI] +synonym: "PSCTK5 inhibitors" RELATED [ChEBI] +synonym: "PTK2 inhibitor" RELATED [ChEBI] +synonym: "PTK2 inhibitors" RELATED [ChEBI] +synonym: "PTK2B inhibitor" RELATED [ChEBI] +synonym: "PTK2B inhibitors" RELATED [ChEBI] +synonym: "PTK6 inhibitor" RELATED [ChEBI] +synonym: "PTK6 inhibitors" RELATED [ChEBI] +synonym: "PYK2 inhibitor" RELATED [ChEBI] +synonym: "PYK2 inhibitors" RELATED [ChEBI] +synonym: "RAFTK inhibitor" RELATED [ChEBI] +synonym: "RAFTK inhibitors" RELATED [ChEBI] +synonym: "RAK inhibitor" RELATED [ChEBI] +synonym: "RAK inhibitors" RELATED [ChEBI] +synonym: "Rlk inhibitor" RELATED [ChEBI] +synonym: "Rlk inhibitors" RELATED [ChEBI] +synonym: "Sik inhibitor" RELATED [ChEBI] +synonym: "Sik inhibitors" RELATED [ChEBI] +synonym: "SLK inhibitor" RELATED [ChEBI] +synonym: "SLK inhibitors" RELATED [ChEBI] +synonym: "SRC inhibitor" RELATED [ChEBI] +synonym: "SRC inhibitors" RELATED [ChEBI] +synonym: "SRC2 inhibitor" RELATED [ChEBI] +synonym: "SRC2 inhibitors" RELATED [ChEBI] +synonym: "SRK inhibitor" RELATED [ChEBI] +synonym: "SRK inhibitors" RELATED [ChEBI] +synonym: "SRM inhibitor" RELATED [ChEBI] +synonym: "SRM inhibitors" RELATED [ChEBI] +synonym: "SRMS inhibitor" RELATED [ChEBI] +synonym: "SRMS inhibitors" RELATED [ChEBI] +synonym: "STD inhibitor" RELATED [ChEBI] +synonym: "STD inhibitors" RELATED [ChEBI] +synonym: "SYK inhibitor" RELATED [ChEBI] +synonym: "SYK inhibitors" RELATED [ChEBI] +synonym: "SYN inhibitor" RELATED [ChEBI] +synonym: "SYN inhibitors" RELATED [ChEBI] +synonym: "Tck inhibitor" RELATED [ChEBI] +synonym: "Tck inhibitors" RELATED [ChEBI] +synonym: "TEC inhibitor" RELATED [ChEBI] +synonym: "TEC inhibitors" RELATED [ChEBI] +synonym: "TNK1 inhibitor" RELATED [ChEBI] +synonym: "TNK1 inhibitors" RELATED [ChEBI] +synonym: "Tsk inhibitor" RELATED [ChEBI] +synonym: "Tsk inhibitors" RELATED [ChEBI] +synonym: "TXK inhibitor" RELATED [ChEBI] +synonym: "TXK inhibitors" RELATED [ChEBI] +synonym: "TYK2 inhibitor" RELATED [ChEBI] +synonym: "TYK2 inhibitors" RELATED [ChEBI] +synonym: "TYK3 inhibitor" RELATED [ChEBI] +synonym: "TYK3 inhibitors" RELATED [ChEBI] +synonym: "YES1 inhibitor" RELATED [ChEBI] +synonym: "YES1 inhibitors" RELATED [ChEBI] +synonym: "YK2 inhibitor" RELATED [ChEBI] +synonym: "YK2 inhibitors" RELATED [ChEBI] +synonym: "ZAP70 inhibitor" RELATED [ChEBI] +synonym: "ZAP70 inhibitors" RELATED [ChEBI] +xref: Wikipedia:Janus_kinase +is_a: CHEBI:38637 ! tyrosine kinase inhibitor +is_a: CHEBI:76817 ! EC 2.7.10.* (protein-tyrosine kinase) inhibitor + [Term] id: CHEBI:76655 name: EC 2.1.* (C1-transferase) inhibitor @@ -19111,6 +36738,57 @@ synonym: "one-carbon-containing group transferase inhibitor" RELATED [ChEBI] synonym: "one-carbon-containing group transferase inhibitors" RELATED [ChEBI] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor +[Term] +id: CHEBI:76663 +name: EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor +namespace: chebi_ontology +def: "A transferase inhibitor that inhibits the transfer of an alkyl (other than methyl) or aryl group (EC 2.5.1.*)." [] +subset: 3_STAR +synonym: "alkyl/aryl (non-methyl) transferase inhibitor" RELATED [ChEBI] +synonym: "alkyl/aryl (non-methyl) transferase inhibitors" RELATED [ChEBI] +synonym: "EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.5.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 2.5.1.* inhibitors" RELATED [ChEBI] +synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitor" RELATED [ChEBI] +synonym: "non-methyl alkyl/aryl transferase (EC 2.5.1.*) inhibitors" RELATED [ChEBI] +synonym: "non-methyl alkyl/aryl transferase inhibitor" RELATED [ChEBI] +synonym: "non-methyl alkyl/aryl transferase inhibitors" RELATED [ChEBI] +synonym: "non-methyl-alkyl or aryl transferase inhibitor" RELATED [ChEBI] +synonym: "non-methyl-alkyl or aryl transferase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76834 ! EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor + +[Term] +id: CHEBI:76668 +name: EC 2.7.* (P-containing group transferase) inhibitor +namespace: chebi_ontology +def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." [] +subset: 3_STAR +synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.* inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.* inhibitors" RELATED [ChEBI] +synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [ChEBI] +synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [ChEBI] +synonym: "phosphorus-containing group transferase inhibitor" RELATED [ChEBI] +synonym: "phosphorus-containing group transferase inhibitors" RELATED [ChEBI] +is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor + +[Term] +id: CHEBI:76697 +name: EC 5.99.* (other isomerases) inhibitor +namespace: chebi_ontology +def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." [] +subset: 3_STAR +synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.* inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor + [Term] id: CHEBI:76710 name: EC 4.* (lyase) inhibitor @@ -19129,6 +36807,21 @@ synonym: "lyase inhibitors" RELATED [ChEBI] xref: Wikipedia:Lyase is_a: CHEBI:23924 ! enzyme inhibitor +[Term] +id: CHEBI:76712 +name: EC 4.2.* (C-O lyase) inhibitor +namespace: chebi_ontology +def: "A lyase inhibitor which inhibits the action of a C-O lyase (EC 4.2.*.*)." [] +subset: 3_STAR +synonym: "C-O lyase (EC 4.2.*) inhibitor" RELATED [ChEBI] +synonym: "C-O lyase (EC 4.2.*) inhibitors" RELATED [ChEBI] +synonym: "C-O lyase inhibitor" RELATED [ChEBI] +synonym: "C-O lyase inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.* (C-O lyase) inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.* inhibitor" RELATED [ChEBI] +synonym: "EC 4.2.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:76710 ! EC 4.* (lyase) inhibitor + [Term] id: CHEBI:76713 name: EC 4.3.* (C-N lyase) inhibitor @@ -19144,6 +36837,236 @@ synonym: "EC 4.3.* inhibitor" RELATED [ChEBI] synonym: "EC 4.3.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76710 ! EC 4.* (lyase) inhibitor +[Term] +id: CHEBI:76725 +name: EC 1.* (oxidoreductase) inhibitor +namespace: chebi_ontology +def: "An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*)." [] +subset: 3_STAR +synonym: "EC 1.* (oxidoreductase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase (EC 1.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase (EC 1.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Oxidoreductase +is_a: CHEBI:23924 ! enzyme inhibitor + +[Term] +id: CHEBI:76726 +name: EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*)." [] +subset: 3_STAR +synonym: "EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.1.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-OH group of donor" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-OH group of donors" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-OH group of donor" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-OH group of donors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76727 +name: EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the aldehyde or oxo group of donors (EC 1.2.*.*)." [] +subset: 3_STAR +synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitor" RELATED [ChEBI] +synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.2.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.2.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donor" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on aldehyde or oxo group of donors" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donor" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on aldehyde/oxo group of donors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde or oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde or oxo group inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group (EC 1.2.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76729 +name: EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-CH group of donors (EC 1.3.*.*)." [] +subset: 3_STAR +synonym: "EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.3.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-CH group of donor" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-CH group of donors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group (EC 1.3.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76731 +name: EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-NH group of donors (EC 1.5.*.*)." [] +subset: 3_STAR +synonym: "EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.5.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.5.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-NH group of donor" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on CH-NH group of donors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-NH group (EC 1.5.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76733 +name: EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on NADH or NADPH (EC 1.6.*.*)." [] +subset: 3_STAR +synonym: "EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on NADH or NADPH" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on NADH or NADPH (EC 1.6.*)" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH (EC 1.6.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76735 +name: EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase of class EC 1.8.*.* (acting on a sulfur group of donors)." [] +subset: 3_STAR +synonym: "EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.8.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.8.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76736 +name: EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on a heme group of donors (EC 1.9.*.*)." [] +subset: 3_STAR +synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitor" RELATED [ChEBI] +synonym: "EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.9.* (oxidoreductase acting on donor heme group) inhibitors" RELATED [ChEBI] +synonym: "EC 1.9.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.9.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on a heme group of donors (EC 1.9.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76737 +name: EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on diphenols and related substances as donors (EC 1.10.*.*)." [] +subset: 3_STAR +synonym: "EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitor" RELATED [ChEBI] +synonym: "EC 1.10.* (oxidoreductases acting on diphenols and related substances as donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.10.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of an oxidoreductase acting on diphenols and related substances as donor" RELATED [ChEBI] +synonym: "inhibitor of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)" RELATED [ChEBI] +synonym: "inhibitor of an oxidoreductase acting on diphenols and related substances as donors" RELATED [ChEBI] +synonym: "inhibitors of an oxidoreductase acting on diphenols and related substances as donor" RELATED [ChEBI] +synonym: "inhibitors of an oxidoreductase acting on diphenols and related substances as donor (EC 1.10.*)" RELATED [ChEBI] +synonym: "inhibitors of an oxidoreductase acting on diphenols and related substances as donors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76738 +name: EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on peroxide as donors (EC 1.11.*.*)." [] +subset: 3_STAR +synonym: "EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.11.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.11.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductases acting on peroxide as donors (EC 1.11.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76740 +name: EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases), EC 1.13.*.*." [] +subset: 3_STAR +synonym: "EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.13.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) (EC 1.13.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76741 +name: EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on hydrogen as donors (EC 1.14.*.*)." [] +subset: 3_STAR +synonym: "EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] +synonym: "inhibitor of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] +synonym: "inhibitors of oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*)" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + +[Term] +id: CHEBI:76744 +name: EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor +namespace: chebi_ontology +def: "An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on CH or CH2 (EC 1.17.*.*)." [] +subset: 3_STAR +synonym: "EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.17.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 (EC 1.17.*) inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 inhibitors" RELATED [ChEBI] +is_a: CHEBI:76725 ! EC 1.* (oxidoreductase) inhibitor + [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor @@ -19162,6 +37085,21 @@ synonym: "hydrolase inhibitors" RELATED [ChEBI] xref: Wikipedia:Hydrolase is_a: CHEBI:23924 ! enzyme inhibitor +[Term] +id: CHEBI:76760 +name: EC 3.1.* (ester hydrolase) inhibitor +namespace: chebi_ontology +def: "A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*)." [] +subset: 3_STAR +synonym: "EC 3.1.* (ester hydrolase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.* inhibitors" RELATED [ChEBI] +synonym: "ester hydrolase (EC 3.1.*) inhibitor" RELATED [ChEBI] +synonym: "ester hydrolase (EC 3.1.*) inhibitors" RELATED [ChEBI] +synonym: "ester hydrolase inhibitor" RELATED [ChEBI] +synonym: "ester hydrolase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor + [Term] id: CHEBI:76764 name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor @@ -19177,6 +37115,128 @@ synonym: "EC 3.5.* inhibitor" RELATED [ChEBI] synonym: "EC 3.5.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor +[Term] +id: CHEBI:76773 +name: EC 3.1.1.* (carboxylic ester hydrolase) inhibitor +namespace: chebi_ontology +def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*)." [] +subset: 3_STAR +synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitor" RELATED [ChEBI] +synonym: "carboxylic ester hydrolase (EC 3.1.1.*) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.1.* (carboxylic ester hydrolase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.1.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor + +[Term] +id: CHEBI:76775 +name: EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor +namespace: chebi_ontology +def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any phosphoric monoester hydrolase (EC 3.1.3.*)." [] +subset: 3_STAR +synonym: "EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.3.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of phosphoric monoester hydrolase" RELATED [ChEBI] +synonym: "inhibitor of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] +synonym: "inhibitors of phosphoric monoester hydrolase" RELATED [ChEBI] +synonym: "inhibitors of phosphoric monoester hydrolase (EC 3.1.3.*)" RELATED [ChEBI] +synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitor" RELATED [ChEBI] +synonym: "phosphoric monoester hydrolase (EC 3.1.3.*) inhibitors" RELATED [ChEBI] +synonym: "phosphoric monoester hydrolase inhibitor" RELATED [ChEBI] +synonym: "phosphoric monoester hydrolase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor + +[Term] +id: CHEBI:76779 +name: EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +namespace: chebi_ontology +def: "Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26)." [] +subset: 3_STAR +synonym: "EC 3.4.21.26 (prolyl oligopeptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.21.26 inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.21.26 inhibitors" RELATED [ChEBI] +synonym: "endoprolylpeptidase inhibitor" RELATED [ChEBI] +synonym: "endoprolylpeptidase inhibitors" RELATED [ChEBI] +synonym: "post-proline cleaving enzyme inhibitor" RELATED [ChEBI] +synonym: "post-proline cleaving enzyme inhibitors" RELATED [ChEBI] +synonym: "post-proline endopeptidase inhibitor" RELATED [ChEBI] +synonym: "post-proline endopeptidase inhibitors" RELATED [ChEBI] +synonym: "proline endopeptidase inhibitor" RELATED [ChEBI] +synonym: "proline endopeptidase inhibitors" RELATED [ChEBI] +synonym: "proline-specific endopeptidase inhibitor" RELATED [ChEBI] +synonym: "proline-specific endopeptidase inhibitors" RELATED [ChEBI] +synonym: "prolyl endopeptidase inhibitor" RELATED [ChEBI] +synonym: "prolyl endopeptidase inhibitors" RELATED [ChEBI] +synonym: "prolyl oligopeptidase (EC 3.4.21.26) inhibitor" RELATED [ChEBI] +synonym: "prolyl oligopeptidase (EC 3.4.21.26) inhibitors" RELATED [ChEBI] +synonym: "prolyl oligopeptidase inhibitor" RELATED [ChEBI] +is_a: CHEBI:5924 ! EC 3.4.21.* (serine endopeptidase) inhibitor + +[Term] +id: CHEBI:76782 +name: EC 3.4.15.* (peptidyl-dipeptidase) inhibitor +namespace: chebi_ontology +def: "Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a peptidyl dipeptidase (EC 3.4.15.*)." [] +subset: 3_STAR +synonym: "EC 3.4.15.* (peptidyl-dipeptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.15.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.15.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of peptidyl-dipeptidases" RELATED [ChEBI] +synonym: "inhibitor of peptidyl-dipeptidases (EC 3.4.15.*)" RELATED [ChEBI] +synonym: "inhibitors of peptidyl-dipeptidases" RELATED [ChEBI] +synonym: "inhibitors of peptidyl-dipeptidases (EC 3.4.15.*)" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase (EC 3.4.15.*) inhibitor" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase (EC 3.4.15.*) inhibitors" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase inhibitor" RELATED [ChEBI] +synonym: "peptidyl-dipeptidase inhibitors" RELATED [ChEBI] +is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor + +[Term] +id: CHEBI:76785 +name: EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor +namespace: chebi_ontology +def: "An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of any endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*)." [] +subset: 3_STAR +synonym: "EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors" RELATED [ChEBI] +synonym: "EC 3.1.26.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.1.26.* inhibitors" RELATED [ChEBI] +synonym: "endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitor" RELATED [ChEBI] +synonym: "endoribonuclease producing 5'-phosphomonoesters (EC 3.1.26.*) inhibitors" RELATED [ChEBI] +synonym: "endoribonuclease producing 5'-phosphomonoesters inhibitor" RELATED [ChEBI] +synonym: "endoribonuclease producing 5'-phosphomonoesters inhibitors" RELATED [ChEBI] +is_a: CHEBI:76760 ! EC 3.1.* (ester hydrolase) inhibitor + +[Term] +id: CHEBI:76797 +name: EC 2.5.1.18 (glutathione transferase) inhibitor +namespace: chebi_ontology +def: "An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of a glutathione transferase (EC 2.5.1.18)." [] +subset: 3_STAR +synonym: "EC 2.5.1.18 (glutathione transferase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.5.1.18 inhibitor" RELATED [ChEBI] +synonym: "EC 2.5.1.18 inhibitors" RELATED [ChEBI] +synonym: "glutathione S-alkyl transferase inhibitor" RELATED [ChEBI] +synonym: "glutathione S-alkyl transferase inhibitors" RELATED [ChEBI] +synonym: "glutathione S-alkyltransferase inhibitor" RELATED [ChEBI] +synonym: "glutathione S-alkyltransferase inhibitors" RELATED [ChEBI] +synonym: "glutathione S-aralkyltransferase inhibitor" RELATED [ChEBI] +synonym: "glutathione S-aralkyltransferase inhibitors" RELATED [ChEBI] +synonym: "glutathione S-aryltransferase inhibitor" RELATED [ChEBI] +synonym: "glutathione S-aryltransferase inhibitors" RELATED [ChEBI] +synonym: "glutathione S-transferase inhibitor" RELATED [ChEBI] +synonym: "glutathione S-transferase inhibitors" RELATED [ChEBI] +synonym: "glutathione transferase (EC 2.5.1.18) inhibitor" RELATED [ChEBI] +synonym: "glutathione transferase (EC 2.5.1.18) inhibitors" RELATED [ChEBI] +synonym: "glutathione transferase inhibitor" RELATED [ChEBI] +synonym: "glutathione transferase inhibitors" RELATED [ChEBI] +synonym: "RX:glutathione R-transferase inhibitor" RELATED [ChEBI] +synonym: "RX:glutathione R-transferase inhibitors" RELATED [ChEBI] +synonym: "S-(hydroxyalkyl)glutathione lyase inhibitor" RELATED [ChEBI] +synonym: "S-(hydroxyalkyl)glutathione lyase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Glutathione_S-transferase +is_a: CHEBI:76663 ! EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor + [Term] id: CHEBI:76807 name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor @@ -19190,6 +37250,53 @@ synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor +[Term] +id: CHEBI:76812 +name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor +namespace: chebi_ontology +def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." [] +subset: 3_STAR +synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.* inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.11.* inhibitors" RELATED [ChEBI] +synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [ChEBI] +synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [ChEBI] +synonym: "protein-serine/threonine kinase inhibitor" RELATED [ChEBI] +synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI] +is_a: CHEBI:37699 ! protein kinase inhibitor + +[Term] +id: CHEBI:76815 +name: EC 2.7.7.* (nucleotidyltransferase) inhibitor +namespace: chebi_ontology +def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*)." [] +subset: 3_STAR +synonym: "EC 2.7.7.* (nucleotidyltransferase) inhibitors" RELATED [ChEBI] +synonym: "inhibitor of nucleotidyltransferases" RELATED [ChEBI] +synonym: "inhibitor of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] +synonym: "inhibitors of nucleotidyltransferases" RELATED [ChEBI] +synonym: "inhibitors of nucleotidyltransferases (EC 2.7.7.*)" RELATED [ChEBI] +synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitor" RELATED [ChEBI] +synonym: "nucleotidyltransferase (EC 2.7.7.*) inhibitors" RELATED [ChEBI] +synonym: "nucleotidyltransferase inhibitor" RELATED [ChEBI] +synonym: "nucleotidyltransferase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor + +[Term] +id: CHEBI:76817 +name: EC 2.7.10.* (protein-tyrosine kinase) inhibitor +namespace: chebi_ontology +def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-tyrosine kinase (EC 2.7.10.*)." [] +subset: 3_STAR +synonym: "EC 2.7.10.* (protein-tyrosine kinase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.10.* inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.10.* inhibitors" RELATED [ChEBI] +synonym: "protein-tyrosine kinase (EC 2.7.10.*) inhibitor" RELATED [ChEBI] +synonym: "protein-tyrosine kinase (EC 2.7.10.*) inhibitors" RELATED [ChEBI] +synonym: "protein-tyrosine kinase inhibitor" RELATED [ChEBI] +synonym: "protein-tyrosine kinase inhibitors" RELATED [ChEBI] +is_a: CHEBI:37699 ! protein kinase inhibitor + [Term] id: CHEBI:76823 name: EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor @@ -19203,6 +37310,35 @@ synonym: "EC 6.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 6.3.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:75600 ! EC 6.3.* (C-N bond-forming ligase) inhibitor +[Term] +id: CHEBI:76824 +name: EC 6.4.1.* (carboxylase) inhibitor +namespace: chebi_ontology +def: "An EC 6.4.* (C-C bond-forming ligase) inhibitor that interferes with the action of a carboxylating enzyme (EC 6.4.1.*)." [] +subset: 3_STAR +synonym: "EC 6.4.1.* (C-C bond forming ligase) inhibitor" RELATED [ChEBI] +synonym: "EC 6.4.1.* (C-C bond forming ligase) inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.1.* (C-C bond-forming ligase) inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.1.* (carboxylase) inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 6.4.1.* inhibitors" RELATED [ChEBI] +synonym: "inhibitor of ligases forming C-C bonds" RELATED [ChEBI] +synonym: "inhibitor of ligases forming C-C bonds (EC 6.4.1.*)" RELATED [ChEBI] +synonym: "inhibitors of ligases forming C-C bonds" RELATED [ChEBI] +synonym: "inhibitors of ligases forming C-C bonds (EC 6.4.1.*)" RELATED [ChEBI] +is_a: CHEBI:75604 ! EC 6.4.* (C-C bond-forming ligase) inhibitor + +[Term] +id: CHEBI:76830 +name: EC 5.99.1.* (miscellaneous isomerase) inhibitor +namespace: chebi_ontology +def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." [] +subset: 3_STAR +synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [ChEBI] +synonym: "EC 5.99.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 5.99.1.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor + [Term] id: CHEBI:76832 name: EC 4.3.1.* (ammonia-lyase) inhibitor @@ -19220,6 +37356,211 @@ synonym: "EC 4.3.1.* inhibitor" RELATED [ChEBI] synonym: "EC 4.3.1.* inhibitors" RELATED [ChEBI] is_a: CHEBI:76713 ! EC 4.3.* (C-N lyase) inhibitor +[Term] +id: CHEBI:76834 +name: EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor +namespace: chebi_ontology +def: "An EC 2.5.* (transferase) inhibitor that inhibits the action of any transferase that transfers an alkyl (other than methyl) or aryl group (EC 2.5.*)." [] +subset: 3_STAR +synonym: "EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.5.* inhibitor" RELATED [ChEBI] +synonym: "EC 2.5.* inhibitors" RELATED [ChEBI] +synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitor" RELATED [ChEBI] +synonym: "non-methyl-alkyl or aryl transferase (EC 2.5.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor + +[Term] +id: CHEBI:76835 +name: EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*)." [] +subset: 3_STAR +synonym: "EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.1.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.1.1.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76726 ! EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor + +[Term] +id: CHEBI:76837 +name: EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor +namespace: chebi_ontology +def: "An EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor that inhibits the action of any oxidoreductase incorporating 2 atoms of oxygen (EC 1.13.11.*)." [] +subset: 3_STAR +synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitor" RELATED [ChEBI] +synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 atoms of oxygen) inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors" RELATED [ChEBI] +synonym: "EC 1.13.11.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.13.11.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on single donors and incorporating 2 atoms of oxygen (EC 1.13.11.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76740 ! EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor + +[Term] +id: CHEBI:76838 +name: EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using reduced flavin or flavoprotein as donor (EC 1.14.14.*)." [] +subset: 3_STAR +synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.14.* (oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.14.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor + +[Term] +id: CHEBI:76840 +name: EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any enzyme in the EC 1.14.99.* (miscellaneous) category." [] +subset: 3_STAR +synonym: "EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.99.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.99.* inhibitors" RELATED [ChEBI] +synonym: "miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor" RELATED [ChEBI] +synonym: "miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor + +[Term] +id: CHEBI:76841 +name: EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor that interferes with the action of any such enzyme incorporating one atom of oxygen and using NADH or NADPH as one donor (EC 1.14.13.*)." [] +subset: 3_STAR +synonym: "EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.13.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.13.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76741 ! EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor + +[Term] +id: CHEBI:76842 +name: vancomycin(1+) +namespace: chebi_ontology +def: "An organic cation that is the conjugate acid of vancomycin, obtained by deprotonation of the carboxy group and protonation of the two amino functions; major species at pH 7.3." [] +subset: 3_STAR +synonym: "vancomycin" RELATED [UniProt] +xref: MetaCyc:CPD-12245 {source="SUBMITTER"} +is_a: CHEBI:25697 ! organic cation +relationship: is_conjugate_acid_of CHEBI:28001 ! vancomycin +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C66H76Cl2N9O24" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/p+1/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYPYJXKWCTUITO-LYRMYLQWSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1450.26100" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1448.43748" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1)c(Cl)c2" xsd:string + +[Term] +id: CHEBI:76848 +name: EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the activity of any such enzyme that uses a disulfide as acceptor (EC 1.17.4.*)." [] +subset: 3_STAR +synonym: "EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.4.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.17.4.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76744 ! EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor + +[Term] +id: CHEBI:76850 +name: EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor that interferes with the function of any such enzyme that uses oxygen as acceptor (EC 1.17.3.*)." [] +subset: 3_STAR +synonym: "EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.17.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.17.3.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76744 ! EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor + +[Term] +id: CHEBI:76853 +name: EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.2.3.*)." [] +subset: 3_STAR +synonym: "EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.2.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.2.3.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor (EC 1.2.3.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76727 ! EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor + +[Term] +id: CHEBI:76859 +name: EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor +namespace: chebi_ontology +def: "An EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor that interferes with the function of any such enzyme in the EC 1.3.98.* (with other acceptors) category." [] +subset: 3_STAR +synonym: "EC 1.3.99.* (oxidoreductase acting on donor CH-CH group with other acceptors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.3.99.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.3.99.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76729 ! EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor + +[Term] +id: CHEBI:76863 +name: EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.5.1.*)." [] +subset: 3_STAR +synonym: "EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.5.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.5.1.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor (EC 1.5.1.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76731 ! EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor + +[Term] +id: CHEBI:76866 +name: EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor that interferes with the action of any such enzyme using a quinone or similar as acceptor (EC 1.6.5.*)." [] +subset: 3_STAR +synonym: "EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.6.5.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.6.5.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76733 ! EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor + +[Term] +id: CHEBI:76869 +name: EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.8.1.*)." [] +subset: 3_STAR +synonym: "EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.8.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.8.1.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor (EC 1.8.1.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76735 ! EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor + +[Term] +id: CHEBI:76870 +name: EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor +namespace: chebi_ontology +def: "An EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor that interferes with the action of any such enzyme using oxygen as acceptor (EC 1.9.3.*)." [] +subset: 3_STAR +synonym: "EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitors" RELATED [ChEBI] +synonym: "EC 1.9.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.9.3.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76736 ! EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor + [Term] id: CHEBI:76874 name: EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor @@ -19233,6 +37574,65 @@ synonym: "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibito synonym: "hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors" RELATED [ChEBI] is_a: CHEBI:76655 ! EC 2.1.* (C1-transferase) inhibitor +[Term] +id: CHEBI:76895 +name: EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor +namespace: chebi_ontology +def: "An EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor that interferes with the action of any such enzyme that catalyses transmembrane movement of substances (EC 3.6.3.*)." [] +subset: 3_STAR +synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitor" RELATED [ChEBI] +synonym: "acid anhydride hydrolase catalysing transmembrane movement of substances (EC 3.6.3.*) inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors" RELATED [ChEBI] +synonym: "EC 3.6.3.* inhibitor" RELATED [ChEBI] +synonym: "EC 3.6.3.* inhibitors" RELATED [ChEBI] +is_a: CHEBI:73216 ! EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor + +[Term] +id: CHEBI:76898 +name: EC 1.14.14.1 (unspecific monooxygenase) inhibitor +namespace: chebi_ontology +def: "An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor that interferes with the action of an unspecified monooxygenase (EC 1.14.14.1)." [] +subset: 3_STAR +synonym: "aryl hydrocarbon hydroxylase inhibitor" RELATED [ChEBI] +synonym: "aryl hydrocarbon hydroxylase inhibitors" RELATED [ChEBI] +synonym: "aryl-4-monooxygenase inhibitor" RELATED [ChEBI] +synonym: "aryl-4-monooxygenase inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.1 (unspecific monooxygenase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.14.14.1 inhibitor" RELATED [ChEBI] +synonym: "EC 1.14.14.1 inhibitors" RELATED [ChEBI] +synonym: "flavoprotein monooxygenase inhibitor" RELATED [ChEBI] +synonym: "flavoprotein monooxygenase inhibitors" RELATED [ChEBI] +synonym: "flavoprotein-linked monooxygenase inhibitor" RELATED [ChEBI] +synonym: "flavoprotein-linked monooxygenase inhibitors" RELATED [ChEBI] +synonym: "microsomal monooxygenase inhibitor" RELATED [ChEBI] +synonym: "microsomal monooxygenase inhibitors" RELATED [ChEBI] +synonym: "microsomal P-450 inhibitor" RELATED [ChEBI] +synonym: "microsomal P-450 inhibitors" RELATED [ChEBI] +synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitor" RELATED [ChEBI] +synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors" RELATED [ChEBI] +synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitor" RELATED [ChEBI] +synonym: "unspecific monooxygenase (EC 1.14.14.1) inhibitors" RELATED [ChEBI] +synonym: "unspecific monooxygenase inhibitor" RELATED [ChEBI] +synonym: "unspecific monooxygenase inhibitors" RELATED [ChEBI] +synonym: "xenobiotic monooxygenase inhibitor" RELATED [ChEBI] +synonym: "xenobiotic monooxygenase inhibitors" RELATED [ChEBI] +is_a: CHEBI:76838 ! EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor + +[Term] +id: CHEBI:76907 +name: EC 4.2.1.* (hydro-lyases) inhibitor +namespace: chebi_ontology +def: "An EC 4.2.* (C-O lyase) inhibitor that interferes with the action of any hydro-lyase (EC 4.2.1.*)." [] +subset: 3_STAR +synonym: "EC 4.2.1.* (hydro-lyase) inhibitor" RELATED [ChEBI] +synonym: "EC 4.2.1.* (hydro-lyase) inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.1.* (hydro-lyases) inhibitors" RELATED [ChEBI] +synonym: "EC 4.2.1.* inhibitor" RELATED [ChEBI] +synonym: "EC 4.2.1.* inhibitors" RELATED [ChEBI] +synonym: "hydro-lyase (EC 4.2.1.*) inhibitor" RELATED [ChEBI] +synonym: "hydro-lyase (EC 4.2.1.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76712 ! EC 4.2.* (C-O lyase) inhibitor + [Term] id: CHEBI:76924 name: plant metabolite @@ -19245,6 +37645,17 @@ synonym: "plant metabolites" RELATED [ChEBI] synonym: "plant secondary metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite +[Term] +id: CHEBI:76932 +name: pathway inhibitor +namespace: chebi_ontology +def: "An enzyme inhibitor that interferes with one or more steps in a metabolic pathway." [] +subset: 3_STAR +synonym: "metabolic pathway inhibitor" RELATED [ChEBI] +synonym: "metabolic pathway inhibitors" RELATED [ChEBI] +synonym: "pathway inhibitors" RELATED [ChEBI] +is_a: CHEBI:23924 ! enzyme inhibitor + [Term] id: CHEBI:76946 name: fungal metabolite @@ -19256,6 +37667,28 @@ subset: 3_STAR synonym: "fungal metabolites" RELATED [ChEBI] is_a: CHEBI:75763 ! eukaryotic metabolite +[Term] +id: CHEBI:76956 +name: Aspergillus metabolite +namespace: chebi_ontology +alt_id: CHEBI:75864 +alt_id: CHEBI:76958 +def: "Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus." [] +subset: 3_STAR +synonym: "Aspergillus metabolites" RELATED [ChEBI] +is_a: CHEBI:76946 ! fungal metabolite + +[Term] +id: CHEBI:76964 +name: Penicillium metabolite +namespace: chebi_ontology +alt_id: CHEBI:76205 +alt_id: CHEBI:76963 +def: "Any fungal metabolite produced during a metabolic reaction in Penicillium." [] +subset: 3_STAR +synonym: "Penicillium metabolites" RELATED [ChEBI] +is_a: CHEBI:76946 ! fungal metabolite + [Term] id: CHEBI:76967 name: human xenobiotic metabolite @@ -19287,6 +37720,317 @@ synonym: "E.coli metabolites" RELATED [ChEBI] synonym: "Escherichia coli metabolites" RELATED [ChEBI] is_a: CHEBI:76969 ! bacterial metabolite +[Term] +id: CHEBI:77019 +name: EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor +namespace: chebi_ontology +def: "An EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor that interferes with the action of any such enzyme in the EC 1.10.99.* category." [] +subset: 3_STAR +synonym: "EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.99.* inhibitor" RELATED [ChEBI] +synonym: "EC 1.10.99.* inhibitors" RELATED [ChEBI] +synonym: "oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitor" RELATED [ChEBI] +synonym: "oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitors" RELATED [ChEBI] +is_a: CHEBI:76737 ! EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor + +[Term] +id: CHEBI:77020 +name: EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor +namespace: chebi_ontology +def: "An EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor that interferes with the action of ribosyldihydronicotinamide dehydrogenase (quinone), EC 1.10.99.2." [] +subset: 3_STAR +synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitor" RELATED [ChEBI] +synonym: "EC 1.10.99.2 (ribosyldihydronicotinamide dehydrogenase (quinone)) inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitors" RELATED [ChEBI] +synonym: "EC 1.10.99.2 inhibitor" RELATED [ChEBI] +synonym: "EC 1.10.99.2 inhibitors" RELATED [ChEBI] +synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitor" RELATED [ChEBI] +synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase-2 inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase-2 inhibitors" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase2 inhibitor" RELATED [ChEBI] +synonym: "NAD(P)H:quinone oxidoreductase2 inhibitors" RELATED [ChEBI] +synonym: "NQO2 inhibitor" RELATED [ChEBI] +synonym: "NQO2 inhibitors" RELATED [ChEBI] +synonym: "NRH:quinone oxidoreductase 2 inhibitor" RELATED [ChEBI] +synonym: "NRH:quinone oxidoreductase 2 inhibitors" RELATED [ChEBI] +synonym: "QR2 inhibitor" RELATED [ChEBI] +synonym: "QR2 inhibitors" RELATED [ChEBI] +synonym: "quinone reductase 2 inhibitor" RELATED [ChEBI] +synonym: "quinone reductase 2 inhibitors" RELATED [ChEBI] +synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitor" RELATED [ChEBI] +synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) inhibitors" RELATED [ChEBI] +xref: Wikipedia:Ribosyldihydronicotinamide_dehydrogenase_(quinone) +is_a: CHEBI:77019 ! EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor + +[Term] +id: CHEBI:77166 +name: 3-oxo-Delta(1),Delta(4)-steroid +namespace: chebi_ontology +def: "A 3-oxo-Delta(1) steroid containing an additional double bond between positions 4 and 5." [] +subset: 3_STAR +synonym: "3-oxo Delta(1),Delta(4)-steroid" RELATED [ChEBI] +synonym: "3-oxo Delta(1),Delta(4)-steroids" RELATED [ChEBI] +synonym: "3-oxo-Delta(1),Delta(4)-steroids" RELATED [ChEBI] +synonym: "3-oxo-Delta(1,4)-steroid" RELATED [ChEBI] +synonym: "3-oxo-Delta(1,4)-steroids" RELATED [ChEBI] +synonym: "a 3-oxo-Delta(1,4)-steroid" RELATED [UniProt] +is_a: CHEBI:20156 ! 3-oxo-Delta(1) steroid +is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H25OR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "269.402" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "269.19054" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12(C=CC(C=C1CCC3C2CCC4(C3CCC4*)C)=O)C" xsd:string + +[Term] +id: CHEBI:77255 +name: EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor +namespace: chebi_ontology +def: "An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83)." [] +subset: 3_STAR +synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitor" RELATED [ChEBI] +synonym: "anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitors" RELATED [ChEBI] +synonym: "EC 3.4.24.83 inhibitor" RELATED [ChEBI] +synonym: "EC 3.4.24.83 inhibitors" RELATED [ChEBI] +synonym: "lethal toxin inhibitor" RELATED [ChEBI] +synonym: "lethal toxin inhibitors" RELATED [ChEBI] +xref: Wikipedia:Anthrax_lethal_factor_endopeptidase +is_a: CHEBI:59107 ! EC 3.4.24.* (metalloendopeptidase) inhibitor + +[Term] +id: CHEBI:77318 +name: pregnane X receptor agonist +namespace: chebi_ontology +def: "An agonist that selectively binds to and activates a pregnane X receptor." [] +subset: 3_STAR +synonym: "pregnane X receptor agonists" RELATED [ChEBI] +synonym: "PXR agonist" RELATED [ChEBI] +synonym: "PXR agonists" RELATED [ChEBI] +xref: Wikipedia:Pregnane_X_receptor +is_a: CHEBI:48705 ! agonist + +[Term] +id: CHEBI:7735 +name: olanzapine +namespace: chebi_ontology +def: "A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4." [] +subset: 3_STAR +synonym: "2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine" EXACT IUPAC_NAME [IUPAC] +synonym: "olanzapina" RELATED INN [ChEBI] +synonym: "Olanzapine" EXACT [KEGG_COMPOUND] +synonym: "olanzapine" RELATED INN [ChEBI] +synonym: "olanzapinum" RELATED INN [ChEBI] +synonym: "Zyprexa" RELATED BRAND_NAME [DrugBank] +xref: CAS:132539-06-1 {source="ChemIDplus"} +xref: Drug_Central:1982 {source="DrugCentral"} +xref: DrugBank:DB00334 +xref: KEGG:C07322 +xref: KEGG:D00454 +xref: Patent:EP454436 +xref: Patent:US5229382 +xref: PMID:18022155 {source="Europe PMC"} +xref: PMID:18504690 {source="Europe PMC"} +xref: PMID:18792627 {source="Europe PMC"} +xref: Reaxys:7655141 {source="Reaxys"} +xref: Wikipedia:Olanzapine +is_a: CHEBI:22720 ! benzodiazepine +is_a: CHEBI:46848 ! N-arylpiperazine +is_a: CHEBI:46920 ! N-methylpiperazine +relationship: has_role CHEBI:37956 ! histamine antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:48876 ! muscarinic antagonist +relationship: has_role CHEBI:50919 ! antiemetic +relationship: has_role CHEBI:50949 ! serotonin uptake inhibitor +relationship: has_role CHEBI:65191 ! second generation antipsychotic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H20N4S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KVWDHTXUZHCGIO-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "312.434" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "312.14087" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "N1=C(C2=C(NC3=CC=CC=C13)SC(=C2)C)N4CCN(CC4)C" xsd:string + +[Term] +id: CHEBI:77397 +name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile +namespace: chebi_ontology +def: "A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group." [] +subset: 3_STAR +synonym: "1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile" EXACT IUPAC_NAME [IUPAC] +xref: CAS:59729-33-8 {source="KEGG COMPOUND"} +xref: KEGG:C07572 +xref: KEGG:D07704 +xref: LINCS:LSM-1585 +is_a: CHEBI:18379 ! nitrile +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:37407 ! cyclic ether +is_a: CHEBI:38831 ! 2-benzofurans +is_a: CHEBI:50996 ! tertiary amino compound +relationship: is_conjugate_base_of CHEBI:77408 ! 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H21FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "324.39190" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "324.16379" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:77402 +name: EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor +namespace: chebi_ontology +def: "An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of trypanothione-disulfide reductase (EC 1.8.1.12)." [] +subset: 3_STAR +synonym: "EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.8.1.12 inhibitor" RELATED [ChEBI] +synonym: "EC 1.8.1.12 inhibitors" RELATED [ChEBI] +synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitor" RELATED [ChEBI] +synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase inhibitors" RELATED [ChEBI] +synonym: "NADPH2:trypanothione oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NADPH2:trypanothione oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "NADPH:trypanothione oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "NADPH:trypanothione oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "trypanothione reductase inhibitor" RELATED [ChEBI] +synonym: "trypanothione reductase inhibitors" RELATED [ChEBI] +synonym: "trypanothione-disulfide reductase (EC 1.8.1.12) inhibitor" RELATED [ChEBI] +synonym: "trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors" RELATED [ChEBI] +synonym: "trypanothione:NADP(+) oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "trypanothione:NADP(+) oxidoreductase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Trypanothione-disulfide_reductase +is_a: CHEBI:76869 ! EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor + +[Term] +id: CHEBI:77405 +name: (R)-citalopram(1+) +namespace: chebi_ontology +def: "A 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium resulting from the protonation of the tertiary amino group of (R)-citalopram." [] +subset: 3_STAR +synonym: "3-[(1R)-5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:77408 ! 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium +relationship: is_conjugate_acid_of CHEBI:36792 ! (R)-citalopram +relationship: is_enantiomer_of CHEBI:77406 ! escitalopram(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H22FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/p+1/t20-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-HXUWFJFHSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "325.39930" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.17107" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C)CCC[C@@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:77406 +name: escitalopram(1+) +namespace: chebi_ontology +def: "A 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium resulting from the protonation of the tertiary amino group of escitalopram." [] +subset: 3_STAR +synonym: "(S)-citalopram(1+)" RELATED [ChEBI] +synonym: "3-[(1S)-5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:77408 ! 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium +relationship: is_conjugate_acid_of CHEBI:36791 ! escitalopram +relationship: is_enantiomer_of CHEBI:77405 ! (R)-citalopram(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H22FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/p+1/t20-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-FQEVSTJZSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "325.39930" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.17107" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:77408 +name: 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium +namespace: chebi_ontology +def: "An ammonium ion resulting from the protonation of the tertiary amino group of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile." [] +subset: 3_STAR +synonym: "3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:77397 ! 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H22FN2O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "WSEQXVZVJXJVFP-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "325.39930" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "325.17107" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1" xsd:string + +[Term] +id: CHEBI:77425 +name: EC 1.1.1.188 (prostaglandin-F synthase) inhibitor +namespace: chebi_ontology +def: "An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-F synthase (EC 1.1.1.188)." [] +subset: 3_STAR +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitor" RELATED [ChEBI] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase inhibitors" RELATED [ChEBI] +synonym: "EC 1.1.1.188 (prostaglandin-F synthase) inhibitors" RELATED [ChEBI] +synonym: "EC 1.1.1.188 inhibitor" RELATED [ChEBI] +synonym: "EC 1.1.1.188 inhibitors" RELATED [ChEBI] +synonym: "NADPH-dependent prostaglandin D2 11-keto reductase inhibitor" RELATED [ChEBI] +synonym: "NADPH-dependent prostaglandin D2 11-keto reductase inhibitors" RELATED [ChEBI] +synonym: "PGD2 11-ketoreductase inhibitor" RELATED [ChEBI] +synonym: "PGD2 11-ketoreductase inhibitors" RELATED [ChEBI] +synonym: "PGF synthetase inhibitor" RELATED [ChEBI] +synonym: "PGF synthetase inhibitors" RELATED [ChEBI] +synonym: "PGF2alpha synthetase inhibitor" RELATED [ChEBI] +synonym: "PGF2alpha synthetase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin 11-keto reductase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin 11-keto reductase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin 11-ketoreductase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin 11-ketoreductase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin D2-ketoreductase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin D2-ketoreductase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin F synthase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin F synthase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin F synthetase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin F synthetase inhibitors" RELATED [ChEBI] +synonym: "prostaglandin-D2 11-reductase inhibitor" RELATED [ChEBI] +synonym: "prostaglandin-D2 11-reductase inhibitors" RELATED [ChEBI] +synonym: "reductase, 15-hydroxy-11-oxoprostaglandin inhibitor" RELATED [ChEBI] +synonym: "reductase, 15-hydroxy-11-oxoprostaglandin inhibitors" RELATED [ChEBI] +synonym: "synthetase, prostaglandin F2alpha inhibitor" RELATED [ChEBI] +synonym: "synthetase, prostaglandin F2alpha inhibitors" RELATED [ChEBI] +xref: Wikipedia:Prostaglandin-F_synthase +is_a: CHEBI:76835 ! EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor + +[Term] +id: CHEBI:77450 +name: dicarboxylic acid monoamide(1-) +namespace: chebi_ontology +def: "A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any dicarboxylic acid monoamide; major species at pH 7.3." [] +subset: 3_STAR +synonym: "a monoamide of a dicarboxylate" RELATED [UniProt] +xref: MetaCyc:DICARBOXYLIC-ACID-MONOAMIDES +is_a: CHEBI:35757 ! monocarboxylic acid anion +relationship: is_conjugate_base_of CHEBI:35735 ! dicarboxylic acid monoamide +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H2NO3R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "88.042" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "88.00347" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)[*]C([O-])=O" xsd:string + +[Term] +id: CHEBI:77615 +name: terbinafine(1+) +namespace: chebi_ontology +def: "An organic cation that is the conjugate acid of terbinafine, obtained by protonation of the amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-aminium" EXACT IUPAC_NAME [IUPAC] +synonym: "terbinafine cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:9448 ! terbinafine +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H26N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/p+1/b9-5+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DOMXUEMWDBAQBQ-WEVVVXLNSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "292.43730" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "292.20598" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+](C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12" xsd:string + [Term] id: CHEBI:77703 name: EC 4.3.1.3 (histidine ammonia-lyase) inhibitor @@ -19313,6 +38057,28 @@ synonym: "L-histidine ammonia-lyase inhibitors" RELATED [ChEBI] xref: Wikipedia:Histidine_ammonia-lyase is_a: CHEBI:76832 ! EC 4.3.1.* (ammonia-lyase) inhibitor +[Term] +id: CHEBI:77715 +name: nasal decongestant +namespace: chebi_ontology +def: "A drug used to relieve nasal congestion in the upper respiratory tract." [] +subset: 3_STAR +synonym: "decongestant" RELATED [ChEBI] +synonym: "decongestants" RELATED [ChEBI] +synonym: "nasal decongestants" RELATED [ChEBI] +xref: Wikipedia:Decongestant +is_a: CHEBI:23888 ! drug + +[Term] +id: CHEBI:77727 +name: delta-lactam +namespace: chebi_ontology +def: "A lactam in which the amide bond is contained within a six-membered ring, which includes the amide nitrogen and the carbonyl carbon." [] +subset: 3_STAR +synonym: "delta-lactam" EXACT [ChEBI] +synonym: "delta-lactams" RELATED [ChEBI] +is_a: CHEBI:24995 ! lactam + [Term] id: CHEBI:77746 name: human metabolite @@ -19397,6 +38163,26 @@ synonym: "food packaging gases" RELATED [ChEBI] xref: Wikipedia:Packaging_gas is_a: CHEBI:64047 ! food additive +[Term] +id: CHEBI:77981 +name: vancomycin aglycone(1-) +namespace: chebi_ontology +def: "A peptide anion that is the conjugate base of vancomycin aglycone and the major microspecies at pH 7.3 (according to Marvin v 6.2.0.)." [] +subset: 3_STAR +synonym: "(1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-{[(2R)-4-methyl-2-(methylazaniumyl)pentanoyl]amino}-48-oxido-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate" EXACT IUPAC_NAME [IUPAC] +synonym: "vancomycin aglycone" RELATED [UniProt] +is_a: CHEBI:50525 ! phenolate anion +is_a: CHEBI:60334 ! peptide anion +relationship: is_conjugate_base_of CHEBI:47724 ! vancomycin aglycone +relationship: is_conjugate_base_of CHEBI:75954 ! vancomycin aglycone zwitterion +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C53H51Cl2N8O17" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C53H52Cl2N8O17/c1-19(2)10-29(57-3)47(71)62-42-44(68)21-5-8-33(27(54)12-21)79-35-14-23-15-36(46(35)70)80-34-9-6-22(13-28(34)55)45(69)43-52(76)61-41(53(77)78)26-16-24(64)17-32(66)38(26)25-11-20(4-7-31(25)65)39(49(73)63-43)60-50(74)40(23)59-48(72)30(18-37(56)67)58-51(42)75/h4-9,11-17,19,29-30,39-45,57,64-66,68-70H,10,18H2,1-3H3,(H2,56,67)(H,58,75)(H,59,72)(H,60,74)(H,61,76)(H,62,71)(H,63,73)(H,77,78)/p-1/t29-,30+,39-,40-,41+,42-,43+,44-,45-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "JHIKFOISFAQTJQ-YZANBJIASA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "1142.92200" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1141.27547" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH2+][C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]5NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(O)c(c1)-c1c(O)cc(O)cc1[C@H](NC5=O)C([O-])=O)c3[O-])c(Cl)c2" xsd:string + [Term] id: CHEBI:78017 name: food propellant @@ -19466,6 +38252,38 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "311.52250" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "311.29501" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string +[Term] +id: CHEBI:7824 +name: oxcarbazepine +namespace: chebi_ontology +def: "A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy." [] +subset: 3_STAR +synonym: "10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide" RELATED [ChemIDplus] +synonym: "10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide" EXACT IUPAC_NAME [IUPAC] +synonym: "oxcarbazepina" RELATED INN [ChemIDplus] +synonym: "Oxcarbazepine" EXACT [KEGG_COMPOUND] +synonym: "oxcarbazepine" RELATED INN [ChemIDplus] +synonym: "oxcarbazepinum" RELATED INN [ChemIDplus] +xref: CAS:28721-07-5 {source="KEGG COMPOUND"} +xref: CAS:28721-07-5 {source="ChemIDplus"} +xref: Drug_Central:2017 {source="DrugCentral"} +xref: KEGG:C07492 +xref: KEGG:D00533 +xref: LINCS:LSM-5219 +xref: PMID:21924464 {source="Europe PMC"} +is_a: CHEBI:3992 ! cyclic ketone +is_a: CHEBI:47804 ! dibenzoazepine +relationship: has_part CHEBI:23004 ! carbamoyl group +relationship: has_role CHEBI:35623 ! anticonvulsant +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H12N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CTRLABGOLIVAIY-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "252.26800" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "252.08988" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=O)N1c2ccccc2CC(=O)c2ccccc12" xsd:string + [Term] id: CHEBI:78295 name: food component @@ -19611,6 +38429,117 @@ subset: 3_STAR synonym: "olefinic compounds" RELATED [ChEBI] is_a: CHEBI:50860 ! organic molecular entity +[Term] +id: CHEBI:79008 +name: (R)-nicotinium(1+) +namespace: chebi_ontology +def: "The conjugate acid of (R)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3." [] +subset: 3_STAR +synonym: "(2R)-1-methyl-2-(pyridin-3-yl)pyrrolidinium" EXACT IUPAC_NAME [IUPAC] +synonym: "(R)-nicotine" RELATED [UniProt] +xref: MetaCyc:R-NICOTINE {source="SUBMITTER"} +xref: MetaCyc:R-NICOTINE "SUBMITTER" +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:39162 ! (R)-nicotine +relationship: is_enantiomer_of CHEBI:59806 ! (S)-nicotinium(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H15N2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SNICXCGAKADSCV-SNVBAGLBSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "163.23900" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "163.12297" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[NH+]1CCC[C@@H]1c1cccnc1" xsd:string + +[Term] +id: CHEBI:79091 +name: EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor +namespace: chebi_ontology +alt_id: CHEBI:75997 +def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24)." [] +subset: 3_STAR +synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitor" RELATED [ChEBI] +synonym: "ATP:protein phosphotransferase (MAPKK-activated) inhibitors" RELATED [ChEBI] +synonym: "c-Jun N-terminal kinase inhibitor" RELATED [ChEBI] +synonym: "c-Jun N-terminal kinase inhibitors" RELATED [ChEBI] +synonym: "Dp38 inhibitor" RELATED [ChEBI] +synonym: "Dp38 inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors" RELATED [ChEBI] +synonym: "EC 2.7.11.24 inhibitor" RELATED [ChEBI] +synonym: "EC 2.7.11.24 inhibitors" RELATED [ChEBI] +synonym: "ERK inhibitor" RELATED [ChEBI] +synonym: "ERK inhibitors" RELATED [ChEBI] +synonym: "ERK1 inhibitor" RELATED [ChEBI] +synonym: "ERK1 inhibitors" RELATED [ChEBI] +synonym: "ERK2 inhibitor" RELATED [ChEBI] +synonym: "ERK2 inhibitors" RELATED [ChEBI] +synonym: "extracellular signal-regulated kinase inhibitor" RELATED [ChEBI] +synonym: "extracellular signal-regulated kinase inhibitors" RELATED [ChEBI] +synonym: "JNK inhibitor" RELATED [ChEBI] +synonym: "JNK inhibitors" RELATED [ChEBI] +synonym: "JNK3alpha1 inhibitor" RELATED [ChEBI] +synonym: "JNK3alpha1 inhibitors" RELATED [ChEBI] +synonym: "LeMPK3 inhibitor" RELATED [ChEBI] +synonym: "LeMPK3 inhibitors" RELATED [ChEBI] +synonym: "MAP kinase inhibitor" RELATED [ChEBI] +synonym: "MAP kinase inhibitors" RELATED [ChEBI] +synonym: "MAP-2 kinase inhibitor" RELATED [ChEBI] +synonym: "MAP-2 kinase inhibitors" RELATED [ChEBI] +synonym: "MAPK inhibitor" RELATED [ChEBI] +synonym: "MAPK inhibitors" RELATED [ChEBI] +synonym: "MBP kinase I inhibitor" RELATED [ChEBI] +synonym: "MBP kinase I inhibitors" RELATED [ChEBI] +synonym: "MBP kinase II inhibitor" RELATED [ChEBI] +synonym: "MBP kinase II inhibitors" RELATED [ChEBI] +synonym: "MEK inhibitor" RELATED [ChEBI] +synonym: "MEK inhibitors" RELATED [ChEBI] +synonym: "microtubule-associated protein 2 kinase inhibitor" RELATED [ChEBI] +synonym: "microtubule-associated protein 2 kinase inhibitors" RELATED [ChEBI] +synonym: "microtubule-associated protein kinase inhibitor" RELATED [ChEBI] +synonym: "microtubule-associated protein kinase inhibitors" RELATED [ChEBI] +synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitor" RELATED [ChEBI] +synonym: "mitogen-activated protein kinase (EC 2.7.11.24) inhibitors" RELATED [ChEBI] +synonym: "mitogen-activated protein kinase inhibitor" RELATED [ChEBI] +synonym: "mitogen-activated protein kinase inhibitors" RELATED [ChEBI] +synonym: "myelin basic protein kinase inhibitor" RELATED [ChEBI] +synonym: "myelin basic protein kinase inhibitors" RELATED [ChEBI] +synonym: "p38-2 inhibitor" RELATED [ChEBI] +synonym: "p38-2 inhibitors" RELATED [ChEBI] +synonym: "p38delta inhibitor" RELATED [ChEBI] +synonym: "p38delta inhibitors" RELATED [ChEBI] +synonym: "p42 mitogen-activated protein kinase inhibitor" RELATED [ChEBI] +synonym: "p42 mitogen-activated protein kinase inhibitors" RELATED [ChEBI] +synonym: "p42(mapk) inhibitor" RELATED [ChEBI] +synonym: "p42(mapk) inhibitors" RELATED [ChEBI] +synonym: "p44mpk inhibitor" RELATED [ChEBI] +synonym: "p44mpk inhibitors" RELATED [ChEBI] +synonym: "PMK-1 inhibitor" RELATED [ChEBI] +synonym: "PMK-1 inhibitors" RELATED [ChEBI] +synonym: "PMK-2 inhibitor" RELATED [ChEBI] +synonym: "PMK-2 inhibitors" RELATED [ChEBI] +synonym: "PMK-3 inhibitor" RELATED [ChEBI] +synonym: "PMK-3 inhibitors" RELATED [ChEBI] +synonym: "pp42 inhibitor" RELATED [ChEBI] +synonym: "pp42 inhibitors" RELATED [ChEBI] +synonym: "pp44(mapk) inhibitor" RELATED [ChEBI] +synonym: "pp44(mapk) inhibitors" RELATED [ChEBI] +synonym: "SAPK inhibitor" RELATED [ChEBI] +synonym: "SAPK inhibitors" RELATED [ChEBI] +synonym: "STK26 inhibitor" RELATED [ChEBI] +synonym: "STK26 inhibitors" RELATED [ChEBI] +synonym: "stress-activated protein kinase inhibitor" RELATED [ChEBI] +synonym: "stress-activated protein kinase inhibitors" RELATED [ChEBI] +xref: Wikipedia:MEK_inhibitor +xref: Wikipedia:Mitogen-activated_protein_kinase +is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor + +[Term] +id: CHEBI:79314 +name: flame retardant +def: "Any compound that is added to manufactured materials to inhibit, suppress, or delay the production of flames and so prevent the spread of fire." [] +synonym: "flame retardants" RELATED [] +is_a: CHEBI:33232 ! application + [Term] id: CHEBI:79387 name: trivalent inorganic anion @@ -19638,6 +38567,265 @@ subset: 3_STAR synonym: "monovalent inorganic anions" RELATED [ChEBI] is_a: CHEBI:24834 ! inorganic anion +[Term] +id: CHEBI:8028 +name: perphenazine +namespace: chebi_ontology +def: "A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10." [] +subset: 3_STAR +synonym: "2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol" RELATED [NIST_Chemistry_WebBook] +synonym: "2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine" RELATED [NIST_Chemistry_WebBook] +synonym: "2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol" EXACT IUPAC_NAME [IUPAC] +synonym: "4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol" RELATED [NIST_Chemistry_WebBook] +synonym: "4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol" RELATED [NIST_Chemistry_WebBook] +synonym: "Chlorpiprazine" RELATED [ChemIDplus] +synonym: "gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine" RELATED [NIST_Chemistry_WebBook] +synonym: "perfenazina" RELATED INN [WHO_MedNet] +synonym: "Perfenazine" RELATED [ChemIDplus] +synonym: "Perphenazin" RELATED [ChemIDplus] +synonym: "Perphenazine" EXACT [KEGG_COMPOUND] +synonym: "perphenazine" RELATED INN [WHO_MedNet] +synonym: "perphenazinum" RELATED INN [WHO_MedNet] +synonym: "Trilafon" RELATED [ChemIDplus] +xref: Beilstein:54730 {source="Beilstein"} +xref: CAS:58-39-9 {source="NIST Chemistry WebBook"} +xref: CAS:58-39-9 {source="ChemIDplus"} +xref: CAS:58-39-9 {source="KEGG COMPOUND"} +xref: Drug_Central:2113 {source="DrugCentral"} +xref: DrugBank:DB00850 +xref: HMDB:HMDB0014988 +xref: KEGG:C07427 +xref: KEGG:D00503 +xref: LINCS:LSM-2224 +xref: Patent:US2766235 +xref: Patent:US2860138 +xref: PMID:14401911 {source="Europe PMC"} +xref: PMID:15674907 {source="Europe PMC"} +xref: PMID:1650428 {source="Europe PMC"} +xref: PMID:26660173 {source="Europe PMC"} +xref: PMID:27150024 {source="Europe PMC"} +xref: Reaxys:54730 {source="Reaxys"} +xref: Wikipedia:Perphenazine +is_a: CHEBI:36683 ! organochlorine compound +is_a: CHEBI:38093 ! phenothiazines +is_a: CHEBI:46851 ! N-(2-hydroxyethyl)piperazine +relationship: has_parent_hydride CHEBI:37931 ! 10H-phenothiazine +relationship: has_role CHEBI:37930 ! phenothiazine antipsychotic drug +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:50919 ! antiemetic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H26ClN3OS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RGCVKNLCSQQDEP-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "403.96946" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "403.14851" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1" xsd:string + +[Term] +id: CHEBI:80630 +name: irinotecan +namespace: chebi_ontology +def: "A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active." [] +subset: 3_STAR +synonym: "(+)-Irinotecan" RELATED [ChemIDplus] +synonym: "(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate" EXACT IUPAC_NAME [IUPAC] +synonym: "HSDB 7607" RELATED [ChemIDplus] +synonym: "Irinophore C" RELATED [ChemIDplus] +synonym: "irinotecan" RELATED INN [ChemIDplus] +synonym: "Irinotecan lactone" RELATED [ChemIDplus] +synonym: "Irinotecan mylan" RELATED [ChemIDplus] +synonym: "irinotecanum" RELATED INN [ChemIDplus] +xref: CAS:97682-44-5 {source="KEGG COMPOUND"} +xref: CAS:97682-44-5 {source="ChemIDplus"} +xref: Drug_Central:1482 {source="DrugCentral"} +xref: DrugBank:DB00762 +xref: HMDB:HMDB0014900 +xref: KEGG:C16641 +xref: KEGG:D08086 +xref: LINCS:LSM-2167 +xref: PDBeChem:CP0 +xref: PMID:26081596 {source="Europe PMC"} +xref: PMID:26352218 {source="Europe PMC"} +xref: PMID:26381420 {source="Europe PMC"} +xref: PMID:26487578 {source="Europe PMC"} +xref: PMID:26503200 {source="Europe PMC"} +xref: PMID:26526067 {source="Europe PMC"} +xref: PMID:26541586 {source="Europe PMC"} +xref: PMID:26574999 {source="Europe PMC"} +xref: PMID:26580826 {source="Europe PMC"} +xref: PMID:26739304 {source="Europe PMC"} +xref: Reaxys:4839096 {source="Reaxys"} +xref: Wikipedia:Irinotecan +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:23003 ! carbamate ester +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:36820 ! ring assembly +is_a: CHEBI:48591 ! N-acylpiperidine +is_a: CHEBI:48626 ! pyranoindolizinoquinoline +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_functional_parent CHEBI:8988 ! SN-38 +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:50276 ! EC 5.99.1.2 (DNA topoisomerase) inhibitor +relationship: has_role CHEBI:68495 ! apoptosis inducer +relationship: is_conjugate_base_of CHEBI:90895 ! irinotecan(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H38N4O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UWKQSNNFCGGAFS-XIFFEERXSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "586.679" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "586.27913" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=CC=C2C(=C1)C(=C3C(=N2)C=4N(C3)C(C5=C(C4)[C@](C(OC5)=O)(CC)O)=O)CC)OC(=O)N6CCC(CC6)N7CCCCC7" xsd:string + +[Term] +id: CHEBI:8093 +name: phenylephrine +namespace: chebi_ontology +def: "A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring." [] +subset: 3_STAR +synonym: "(-)-m-hydroxy-alpha-(methylaminomethyl)benzyl alcohol" RELATED [NIST_Chemistry_WebBook] +synonym: "3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol" EXACT IUPAC_NAME [IUPAC] +synonym: "Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino)methyl]-, (R)-" RELATED [NIST_Chemistry_WebBook] +synonym: "Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)-" RELATED [ChemIDplus] +synonym: "Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, (-)-" RELATED [ChemIDplus] +synonym: "fenilefrina" RELATED INN [ChemIDplus] +synonym: "l-(3-Hydroxyphenyl)-N-methylethanolamine" RELATED [NIST_Chemistry_WebBook] +synonym: "Phenylephrine" EXACT [KEGG_COMPOUND] +synonym: "phenylephrine" RELATED INN [ChemIDplus] +synonym: "phenylephrinum" RELATED INN [ChemIDplus] +synonym: "R(-)-Phenylephrine" RELATED [ChemIDplus] +xref: CAS:59-42-7 {source="NIST Chemistry WebBook"} +xref: CAS:59-42-7 {source="ChemIDplus"} +xref: CAS:59-42-7 {source="KEGG COMPOUND"} +xref: Drug_Central:2146 {source="DrugCentral"} +xref: DrugBank:DB00388 +xref: HMDB:HMDB0002182 +xref: KEGG:C07441 +xref: KEGG:D08365 +xref: LINCS:LSM-15380 +xref: Patent:US1932347 +xref: Patent:US1954389 +xref: PMID:10100801 {source="Europe PMC"} +xref: PMID:11064374 {source="Europe PMC"} +xref: PMID:11528305 {source="Europe PMC"} +xref: PMID:12172708 {source="Europe PMC"} +xref: PMID:15492464 {source="Europe PMC"} +xref: PMID:15522277 {source="Europe PMC"} +xref: PMID:15686119 {source="Europe PMC"} +xref: PMID:19372348 {source="Europe PMC"} +xref: PMID:19427353 {source="Europe PMC"} +xref: PMID:24588024 {source="Europe PMC"} +xref: PMID:25719378 {source="Europe PMC"} +xref: PMID:25902390 {source="Europe PMC"} +xref: PMID:26143019 {source="Europe PMC"} +xref: PMID:26428281 {source="Europe PMC"} +xref: PMID:26513673 {source="Europe PMC"} +xref: PMID:26597497 {source="Europe PMC"} +xref: PMID:26709790 {source="Europe PMC"} +xref: PMID:26873547 {source="Europe PMC"} +xref: PMID:26928367 {source="Europe PMC"} +xref: PMID:26991619 {source="Europe PMC"} +xref: PMID:26992790 {source="Europe PMC"} +xref: PMID:27020488 {source="Europe PMC"} +xref: PMID:27117950 {source="Europe PMC"} +xref: PMID:27164015 {source="Europe PMC"} +xref: PMID:27249899 {source="Europe PMC"} +xref: PMID:27288620 {source="Europe PMC"} +xref: PMID:28166217 {source="Europe PMC"} +xref: PMID:7516005 {source="Europe PMC"} +xref: PMID:7879981 {source="Europe PMC"} +xref: PMID:8763311 {source="Europe PMC"} +xref: PMID:8853328 {source="Europe PMC"} +xref: Reaxys:3198815 {source="Reaxys"} +xref: Wikipedia:Phenylephrine +is_a: CHEBI:25990 ! phenylethanolamines +is_a: CHEBI:33853 ! phenols +is_a: CHEBI:50995 ! secondary amino compound +relationship: has_role CHEBI:35524 ! sympathomimetic agent +relationship: has_role CHEBI:35569 ! alpha-adrenergic agonist +relationship: has_role CHEBI:38147 ! cardiotonic drug +relationship: has_role CHEBI:50267 ! protective agent +relationship: has_role CHEBI:50513 ! mydriatic agent +relationship: has_role CHEBI:50514 ! vasoconstrictor agent +relationship: has_role CHEBI:77715 ! nasal decongestant +relationship: is_conjugate_base_of CHEBI:132294 ! phenylephrine(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C9H13NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SONNWYBIRXJNDC-VIFPVBQESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "167.20500" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "167.09463" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CNC[C@H](O)c1cccc(O)c1" xsd:string + +[Term] +id: CHEBI:8107 +name: phenytoin +namespace: chebi_ontology +alt_id: CHEBI:100921 +def: "A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5." [] +subset: 3_STAR +synonym: "5,5-Diphenyl-imidazolidine-2,4-dione" RELATED [ChEMBL] +synonym: "5,5-diphenylimidazolidine-2,4-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "5,5-diphenylimidazolidine-2,4-dione" RELATED [ChEMBL] +synonym: "5,5-diphenyltetrahydro-1H-2,4-imidazoledione" RELATED [ChEMBL] +synonym: "DILANTIN" RELATED [ChEMBL] +synonym: "fenitoina" RELATED INN [ChemIDplus] +synonym: "PHENTYTOIN" RELATED [ChEMBL] +synonym: "phenytoin" RELATED INN [ChemIDplus] +synonym: "phenytoine" RELATED INN [ChemIDplus] +synonym: "phenytoinum" RELATED INN [ChemIDplus] +xref: Beilstein:384532 {source="Beilstein"} +xref: CAS:57-41-0 {source="ChemIDplus"} +xref: CAS:57-41-0 {source="KEGG COMPOUND"} +xref: Drug_Central:2152 {source="DrugCentral"} +xref: DrugBank:DB00252 +xref: HMDB:HMDB0014397 +xref: KEGG:C07443 +xref: KEGG:D00512 +xref: LINCS:LSM-5663 +xref: Patent:WO2012174723 +xref: PMID:10698828 {source="Europe PMC"} +xref: PMID:12952753 {source="Europe PMC"} +xref: PMID:15246836 {source="Europe PMC"} +xref: PMID:15744730 {source="Europe PMC"} +xref: PMID:16303054 {source="Europe PMC"} +xref: PMID:7105825 {source="Europe PMC"} +xref: PMID:7602118 {source="Europe PMC"} +xref: PMID:9186244 {source="Europe PMC"} +xref: Reaxys:384532 {source="Reaxys"} +xref: Wikipedia:Phenytoin +is_a: CHEBI:24628 ! imidazolidine-2,4-dione +relationship: has_functional_parent CHEBI:27612 ! hydantoin +relationship: has_role CHEBI:35623 ! anticonvulsant +relationship: has_role CHEBI:38633 ! sodium channel blocker +relationship: has_role CHEBI:50905 ! teratogenic agent +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C15H12N2O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "CXOFVDLJLONNDW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "252.26800" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "252.08988" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1" xsd:string + +[Term] +id: CHEBI:81278 +name: 4-(4-Hydroxyphenyl)-2-butanol +namespace: chebi_ontology +subset: 2_STAR +synonym: "4-HPB" RELATED [KEGG_COMPOUND] +synonym: "Betuligenol" RELATED [KEGG_COMPOUND] +synonym: "Rhododendrol" RELATED [KEGG_COMPOUND] +xref: KEGG:C17690 +is_a: CHEBI:33853 ! phenols +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H14O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFUCGABQOMYVJW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "166.21700" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "166.09938" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(O)CCc1ccc(O)cc1" xsd:string + [Term] id: CHEBI:81567 name: thyroid stimulating hormone @@ -19693,6 +38881,79 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string +[Term] +id: CHEBI:82711 +name: aryl thiol +namespace: chebi_ontology +def: "An aryl thiol is a thiol in which a sulfanyl group, SH, is attached to an aryl group." [] +subset: 3_STAR +synonym: "an aryl thiol" RELATED [UniProt] +xref: KEGG:C01336 {source="SUBMITTER"} +is_a: CHEBI:29256 ! thiol +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "HSR" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "33.074" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.97990" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "S[*]" xsd:string + +[Term] +id: CHEBI:82978 +name: paliperidone +namespace: chebi_ontology +def: "A racemate comprising equimolar amounts of (R)- and (S)-paliperidone. Paliperidone is the primary active metabolite of the older antipsychotic risperidone and is used for treatment of schizophrenia." [] +subset: 3_STAR +synonym: "(+-)-paliperidone" RELATED [ChemIDplus] +synonym: "(RS)-paliperidone" RELATED [ChemIDplus] +synonym: "9-hydroxy-risperidone" RELATED [ChemIDplus] +synonym: "9-Hydroxyrisperidone" RELATED [DrugBank] +synonym: "9-OH-risperidone" RELATED [ChemIDplus] +synonym: "Invega" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "paliperidone" RELATED INN [KEGG_DRUG] +synonym: "R 76477" RELATED [ChemIDplus] +synonym: "R-76477" RELATED [ChemIDplus] +synonym: "rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one" EXACT IUPAC_NAME [IUPAC] +synonym: "rac-paliperidone" RELATED [ChemIDplus] +synonym: "racemic paliperidone" RELATED [ChemIDplus] +synonym: "Ro-76477" RELATED [DrugBank] +synonym: "RO76477" RELATED [ChemIDplus] +xref: CAS:144598-75-4 {source="ChemIDplus"} +xref: CAS:144598-75-4 {source="KEGG DRUG"} +xref: DrugBank:DB01267 +xref: HMDB:HMDB0015396 +xref: KEGG:D05339 +xref: PMID:23428785 {source="Europe PMC"} +xref: PMID:24289141 {source="Europe PMC"} +xref: PMID:24324228 {source="Europe PMC"} +xref: PMID:24346811 {source="Europe PMC"} +xref: PMID:24400982 {source="Europe PMC"} +xref: PMID:24462396 {source="Europe PMC"} +xref: PMID:24491033 {source="Europe PMC"} +xref: PMID:24556260 {source="Europe PMC"} +xref: PMID:24597755 {source="Europe PMC"} +xref: PMID:24690136 {source="Europe PMC"} +xref: PMID:24752928 {source="Europe PMC"} +xref: PMID:24829608 {source="Europe PMC"} +xref: PMID:24962437 {source="Europe PMC"} +xref: PMID:25085446 {source="Europe PMC"} +xref: PMID:25147315 {source="Europe PMC"} +xref: PMID:25377151 {source="Europe PMC"} +xref: Reaxys:8808385 {source="Reaxys"} +xref: Wikipedia:Paliperidone +is_a: CHEBI:60911 ! racemate +relationship: has_part CHEBI:83805 ! (S)-paliperidone +relationship: has_part CHEBI:83806 ! (R)-paliperidone +relationship: has_role CHEBI:37890 ! alpha-adrenergic antagonist +relationship: has_role CHEBI:37955 ! H1-receptor antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:63726 ! neuroprotective agent +relationship: has_role CHEBI:65191 ! second generation antipsychotic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27FN4O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "426.48390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.20672" xsd:string + [Term] id: CHEBI:83038 name: Daphnia galeata metabolite @@ -19742,6 +39003,26 @@ synonym: "Daphnia metabolites" RELATED [ChEBI] xref: Wikipedia:Daphnia is_a: CHEBI:83039 ! crustacean metabolite +[Term] +id: CHEBI:83317 +name: sterol biosynthesis inhibitor +namespace: chebi_ontology +def: "Any compound that inhibits the biosynthesis of any sterol." [] +subset: 3_STAR +synonym: "sterol biosynthesis inhibitors" RELATED [ChEBI] +is_a: CHEBI:35222 ! inhibitor +is_a: CHEBI:52206 ! biochemical role + +[Term] +id: CHEBI:83328 +name: pyrazolone +namespace: chebi_ontology +def: "A member of the class of pyrazoles in which one of the carbons of the pyrazole ring is substituted by an oxo group." [] +subset: 3_STAR +synonym: "pyrazolones" RELATED [ChEBI] +is_a: CHEBI:26410 ! pyrazoles +is_a: CHEBI:36586 ! carbonyl compound + [Term] id: CHEBI:8337 name: porphyrin @@ -19775,6 +39056,148 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "310.35200" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "310.12185" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "c1cc2cc3ccc(cc4ccc(cc5ccc(cc1n2)[nH]5)n4)[nH]3" xsd:string +[Term] +id: CHEBI:83403 +name: monochlorobenzenes +namespace: chebi_ontology +def: "Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine." [] +subset: 3_STAR +is_a: CHEBI:23132 ! chlorobenzenes + +[Term] +id: CHEBI:83565 +name: (trifluoromethyl)benzenes +namespace: chebi_ontology +def: "An organofluorine compound that is (trifluoromethyl)benzene and derivatives arising from substitution of one or more of the phenyl hydrogens." [] +subset: 3_STAR +is_a: CHEBI:22712 ! benzenes +is_a: CHEBI:37143 ! organofluorine compound +relationship: has_part CHEBI:50127 ! trifluoromethyl group + +[Term] +id: CHEBI:83575 +name: monofluorobenzenes +namespace: chebi_ontology +def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying a single fluorine substitutent." [] +subset: 3_STAR +synonym: "monofluorobenzenes" EXACT [ChEBI] +is_a: CHEBI:35496 ! fluorobenzenes + +[Term] +id: CHEBI:8378 +name: prednisolone +namespace: chebi_ontology +def: "A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone." [] +subset: 3_STAR +synonym: "(11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione" RELATED [ChEBI] +synonym: "1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione" RELATED [ChemIDplus] +synonym: "1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol" RELATED [ChemIDplus] +synonym: "11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene" RELATED [ChemIDplus] +synonym: "Delta(1)-dehydrocortisol" RELATED [ChemIDplus] +synonym: "Delta(1)-dehydrohydrocortisone" RELATED [ChemIDplus] +synonym: "Delta(1)-hydrocortisone" RELATED [ChemIDplus] +synonym: "hydroretrocortine" RELATED [ChemIDplus] +synonym: "metacortandralone" RELATED [ChemIDplus] +synonym: "prednisolona" RELATED INN [ChemIDplus] +synonym: "prednisolone" RELATED INN [WHO_MedNet] +synonym: "prednisolone" RELATED INN [ChemIDplus] +synonym: "prednisolonum" RELATED INN [ChemIDplus] +xref: Beilstein:1354103 {source="ChemIDplus"} +xref: CAS:50-24-8 {source="ChemIDplus"} +xref: CAS:50-24-8 {source="KEGG COMPOUND"} +xref: Drug_Central:2245 {source="DrugCentral"} +xref: DrugBank:DB00860 +xref: HMDB:HMDB0014998 +xref: KEGG:C07369 +xref: KEGG:D00472 +xref: PMID:11294518 {source="Europe PMC"} +xref: PMID:23625982 {source="Europe PMC"} +xref: PMID:24392764 {source="Europe PMC"} +xref: Reaxys:1354103 {source="Reaxys"} +xref: VSDB:1848 +xref: Wikipedia:Prednisolone +is_a: CHEBI:139590 ! primary alpha-hydroxy ketone +is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone +is_a: CHEBI:24261 ! glucocorticoid +is_a: CHEBI:35342 ! 17alpha-hydroxy steroid +is_a: CHEBI:35344 ! 21-hydroxy steroid +is_a: CHEBI:35346 ! 11beta-hydroxy steroid +is_a: CHEBI:36885 ! 20-oxo steroid +is_a: CHEBI:61313 ! C21-steroid +is_a: CHEBI:77166 ! 3-oxo-Delta(1),Delta(4)-steroid +relationship: has_functional_parent CHEBI:34073 ! Delta(1)-progesterone +relationship: has_role CHEBI:35472 ! anti-inflammatory drug +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:35705 ! immunosuppressive agent +relationship: has_role CHEBI:37962 ! adrenergic agent +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H28O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OIGNJSKKLXVSLS-VWUMJDOOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "360.44400" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.19367" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO" xsd:string + +[Term] +id: CHEBI:83804 +name: 3-\{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one +namespace: chebi_ontology +def: "A member of the class of pyridopyrimidines that is 9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2." [] +subset: 3_STAR +synonym: "3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:35681 ! secondary alcohol +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:38932 ! pyridopyrimidine +is_a: CHEBI:48585 ! heteroarylpiperidine +is_a: CHEBI:51545 ! 1,2-benzoxazoles +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27FN4O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PMXMIIMHBWHSKN-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "426.48390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.20672" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1nc2C(O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12" xsd:string + +[Term] +id: CHEBI:83805 +name: (S)-paliperidone +namespace: chebi_ontology +def: "A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (S)-enantiomer of paliperidone." [] +subset: 3_STAR +synonym: "(9S)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one" EXACT IUPAC_NAME [IUPAC] +xref: Reaxys:24179044 {source="Reaxys"} +is_a: CHEBI:83804 ! 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one +relationship: is_enantiomer_of CHEBI:83806 ! (R)-paliperidone +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27FN4O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/t19-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PMXMIIMHBWHSKN-IBGZPJMESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "426.48390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.20672" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1nc2[C@@H](O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12" xsd:string + +[Term] +id: CHEBI:83806 +name: (R)-paliperidone +namespace: chebi_ontology +def: "A 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (R)-enantiomer of paliperidone." [] +subset: 3_STAR +synonym: "(9R)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one" EXACT IUPAC_NAME [IUPAC] +xref: Reaxys:14642853 {source="Reaxys"} +is_a: CHEBI:83804 ! 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one +relationship: is_enantiomer_of CHEBI:83805 ! (S)-paliperidone +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27FN4O3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/t19-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PMXMIIMHBWHSKN-LJQANCHMSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "426.48390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "426.20672" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1nc2[C@H](O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12" xsd:string + [Term] id: CHEBI:83811 name: proteinogenic amino acid derivative @@ -19846,6 +39269,16 @@ synonym: "amino acid derivatives" RELATED [ChEBI] synonym: "modified amino acids" RELATED [ChEBI] is_a: CHEBI:35352 ! organonitrogen compound +[Term] +id: CHEBI:83822 +name: non-proteinogenic L-alpha-amino acid +namespace: chebi_ontology +def: "Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." [] +subset: 3_STAR +synonym: "non-proteinogenic L-alpha-amino acids" RELATED [ChEBI] +is_a: CHEBI:15705 ! L-alpha-amino acid +is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid + [Term] id: CHEBI:83824 name: L-cysteine derivative @@ -19914,6 +39347,23 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "58.036" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "58.00548" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)C[*]" xsd:string +[Term] +id: CHEBI:83976 +name: 2-methyl fatty acid anion +namespace: chebi_ontology +def: "A methyl-branched fatty acid anion obtained by deprotonation of the carboxy group of any 2-methyl fatty acid; major species at pH 7.3." [] +subset: 3_STAR +synonym: "2-methyl fatty acid(1-)" RELATED [SUBMITTER] +synonym: "2-methyl-branched fatty acid anion" RELATED [ChEBI] +synonym: "2-methyl-branched fatty acid(1-)" RELATED [ChEBI] +synonym: "a 2-methyl fatty acid" RELATED [UniProt] +is_a: CHEBI:67013 ! methyl-branched fatty acid anion +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C3H4O2R" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "72.063" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "72.02113" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC([*])C([O-])=O" xsd:string + [Term] id: CHEBI:83982 name: L-glutamic acid derivative @@ -19934,6 +39384,40 @@ subset: 3_STAR synonym: "human urinary metabolites" RELATED [ChEBI] is_a: CHEBI:77746 ! human metabolite +[Term] +id: CHEBI:84144 +name: L-phenylalanine derivative +namespace: chebi_ontology +def: "A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom." [] +subset: 3_STAR +synonym: "L-phenylalanine derivatives" RELATED [ChEBI] +is_a: CHEBI:25985 ! phenylalanine derivative +is_a: CHEBI:83811 ! proteinogenic amino acid derivative +relationship: has_functional_parent CHEBI:17295 ! L-phenylalanine + +[Term] +id: CHEBI:84276 +name: methyl phenyl(piperidin-2-yl)acetate +namespace: chebi_ontology +def: "A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group." [] +subset: 3_STAR +synonym: "alpha-phenyl-2-piperidineacetic acid methyl ester" RELATED [NIST_Chemistry_WebBook] +synonym: "methyl alpha-phenyl-alpha-(2-piperidyl)acetate" RELATED [NIST_Chemistry_WebBook] +synonym: "methyl alpha-phenyl-alpha-2-piperidinylacetate" RELATED [NIST_Chemistry_WebBook] +synonym: "methyl phenidylacetate" RELATED [ChemIDplus] +synonym: "methyl phenyl(piperidin-2-yl)acetate" EXACT IUPAC_NAME [IUPAC] +synonym: "methylphenidan" RELATED [ChemIDplus] +is_a: CHEBI:25248 ! methyl ester +is_a: CHEBI:26151 ! piperidines +is_a: CHEBI:85139 ! beta-amino acid ester +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H19NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DUGOZIWVEXMGBE-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "233.30620" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "233.14158" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COC(=O)C(C1CCCCN1)c1ccccc1" xsd:string + [Term] id: CHEBI:84410 name: sphingoid base(1+) @@ -20019,6 +39503,17 @@ xref: PMID:25643794 {source="Europe PMC"} xref: Wikipedia:Skin_whitening is_a: CHEBI:64857 ! cosmetic +[Term] +id: CHEBI:85139 +name: beta-amino acid ester +namespace: chebi_ontology +def: "An amino acid ester resulting from the formal condensation of the carboxy group of a beta-amino acid with the hydroxy group of an alcohol or phenol." [] +subset: 3_STAR +synonym: "beta-amino acid esters" RELATED [ChEBI] +is_a: CHEBI:46668 ! amino acid ester +is_a: CHEBI:83812 ! non-proteinogenic amino acid derivative +relationship: has_functional_parent CHEBI:33706 ! beta-amino acid + [Term] id: CHEBI:85234 name: human blood serum metabolite @@ -20068,6 +39563,312 @@ xref: Wikipedia:Antifungal is_a: CHEBI:35441 ! antiinfective agent is_a: CHEBI:35718 ! antifungal agent +[Term] +id: CHEBI:86328 +name: antifungal agrochemical +namespace: chebi_ontology +def: "Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties." [] +subset: 3_STAR +synonym: "agrichemical fungicide" RELATED [ChEBI] +synonym: "agrichemical fungicides" RELATED [ChEBI] +synonym: "agrochemical fungicide" RELATED [ChEBI] +synonym: "agrochemical fungicides" RELATED [ChEBI] +synonym: "anti-fungal agrichemical" RELATED [ChEBI] +synonym: "anti-fungal agrichemicals" RELATED [ChEBI] +synonym: "anti-fungal agrochemical" RELATED [ChEBI] +synonym: "anti-fungal agrochemicals" RELATED [ChEBI] +synonym: "antifungal agrichemical" RELATED [ChEBI] +synonym: "antifungal agrichemicals" RELATED [ChEBI] +synonym: "antifungal agrochemicals" RELATED [ChEBI] +is_a: CHEBI:24127 ! fungicide +is_a: CHEBI:33286 ! agrochemical + +[Term] +id: CHEBI:87039 +name: bridged diphenyl fungicide +namespace: chebi_ontology +def: "Any organic aromatic compound containing two phenyl (or substituted phenyl) groups attached to a single carbon or heteroatom and which has been used as a fungicide." [] +subset: 3_STAR +synonym: "bridged diphenyl fungicides" RELATED [ChEBI] +is_a: CHEBI:60644 ! bridged diphenyl antifungal agent +relationship: has_role CHEBI:24127 ! fungicide + +[Term] +id: CHEBI:8707 +name: quetiapine +namespace: chebi_ontology +subset: 3_STAR +synonym: "2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol" RELATED [KEGG_COMPOUND] +synonym: "2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol" EXACT IUPAC_NAME [IUPAC] +synonym: "quetiapina" RELATED INN [ChEBI] +synonym: "Quetiapine" EXACT [KEGG_COMPOUND] +synonym: "quetiapine" RELATED INN [ChEBI] +synonym: "quetiapinum" RELATED INN [ChEBI] +xref: CAS:111974-69-7 {source="ChemIDplus"} +xref: Drug_Central:2337 {source="DrugCentral"} +xref: DrugBank:DB01224 +xref: KEGG:C07397 +xref: KEGG:D08456 +xref: LINCS:LSM-3543 +xref: Patent:EP240228 +xref: Patent:US4879288 +xref: Wikipedia:Quetiapine +is_a: CHEBI:39268 ! dibenzothiazepine +is_a: CHEBI:46845 ! N-alkylpiperazine +is_a: CHEBI:46848 ! N-arylpiperazine +relationship: has_role CHEBI:37887 ! adrenergic antagonist +relationship: has_role CHEBI:37956 ! histamine antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:65191 ! second generation antipsychotic +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H25N3O2S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "URKOMYMAXPYINW-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "383.50700" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "383.16675" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12" xsd:string + +[Term] +id: CHEBI:87127 +name: allylamine antifungal drug +namespace: chebi_ontology +def: "An organonitrogen compound that contains an amino group that is attached to a carbon which is itself attached to an olefinic carbon and which has been used as an antifungal drug." [] +subset: 3_STAR +synonym: "allylamine antifungal drugs" RELATED [ChEBI] +xref: PMID:1732066 {source="Europe PMC"} +is_a: CHEBI:35352 ! organonitrogen compound +relationship: has_role CHEBI:86327 ! antifungal drug + +[Term] +id: CHEBI:87228 +name: sulfonamide antibiotic +namespace: chebi_ontology +def: "A class of sulfonamides whose members generally have bacteriostatic antibiotic properties." [] +subset: 3_STAR +synonym: "sulfonamide antibiotics" RELATED [ChEBI] +synonym: "sulfonamide antimicrobial agent" RELATED [ChEBI] +synonym: "sulfonamide antimicrobial agents" RELATED [ChEBI] +synonym: "sulphonamide antibiotic" RELATED [ChEBI] +synonym: "sulphonamide antibiotics" RELATED [ChEBI] +xref: PMID:24443047 {source="Europe PMC"} +xref: PMID:24928456 {source="Europe PMC"} +xref: PMID:25064257 {source="Europe PMC"} +xref: PMID:25796473 {source="Europe PMC"} +xref: PMID:26177406 {source="Europe PMC"} +xref: Wikipedia:Sulfonamide_(medicine) +is_a: CHEBI:35358 ! sulfonamide +relationship: has_role CHEBI:33281 ! antimicrobial agent + +[Term] +id: CHEBI:87230 +name: nitrofuran antibiotic +namespace: chebi_ontology +def: "A member of the class of furans in which the furan ring is substituted by a nitro group and which also has significant antibiotic properties." [] +subset: 3_STAR +synonym: "nitrofuran antibiotics" RELATED [ChEBI] +synonym: "nitrofuran antimicrobial agent" RELATED [ChEBI] +synonym: "nitrofuran antimicrobial agents" RELATED [ChEBI] +xref: AGR:IND44688035 {source="Europe PMC"} +xref: PMID:15776153 {source="Europe PMC"} +xref: PMID:16999120 {source="Europe PMC"} +xref: PMID:17691006 {source="Europe PMC"} +xref: PMID:23785991 {source="Europe PMC"} +xref: PMID:25437357 {source="Europe PMC"} +xref: Wikipedia:Nitrofuran +is_a: CHEBI:24129 ! furans +is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic +is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic +is_a: CHEBI:35716 ! C-nitro compound + +[Term] +id: CHEBI:87631 +name: statin +namespace: chebi_ontology +def: "Any organooxygen compound whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [] +subset: 3_STAR +synonym: "statins" RELATED [ChEBI] +xref: PMID:1464741 {source="Europe PMC"} +xref: PMID:15531285 {source="Europe PMC"} +xref: PMID:20467214 {source="Europe PMC"} +xref: PMID:25488134 {source="Europe PMC"} +xref: PMID:25655639 {source="Europe PMC"} +xref: PMID:25808421 {source="Europe PMC"} +xref: PMID:25894795 {source="Europe PMC"} +xref: PMID:26002574 {source="Europe PMC"} +xref: Wikipedia:Statin +is_a: CHEBI:36963 ! organooxygen compound +relationship: has_role CHEBI:35664 ! EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor +relationship: has_role CHEBI:35821 ! anticholesteremic drug + +[Term] +id: CHEBI:87632 +name: statin (naturally occurring) +namespace: chebi_ontology +def: "Any statin that occurs in nature. The class includes compactin (also known as mevastatin), isolated from a fermentation broth of Penicillium citrinum, and lovastatin, isolated from Aspergillus terreus." [] +subset: 3_STAR +synonym: "naturally occurring statin" RELATED [ChEBI] +synonym: "naturally occurring statins" RELATED [ChEBI] +synonym: "statins (naturally occurring)" RELATED [ChEBI] +xref: Patent:WO9832751 +xref: PMID:1464741 {source="Europe PMC"} +xref: PMID:20467214 {source="Europe PMC"} +xref: PMID:21697731 {source="Europe PMC"} +xref: PMID:22060290 {source="Europe PMC"} +xref: PMID:22302254 {source="Europe PMC"} +is_a: CHEBI:87631 ! statin +relationship: has_role CHEBI:25212 ! metabolite + +[Term] +id: CHEBI:87633 +name: statin (semi-synthetic) +namespace: chebi_ontology +def: "A statin that is derived from a naturally occurring statin by partial chemical synthesis." [] +subset: 3_STAR +synonym: "semi-synthetic statin" RELATED [ChEBI] +synonym: "semi-synthetic statins" RELATED [ChEBI] +synonym: "statins (semi-synthetic)" RELATED [ChEBI] +xref: PMID:1464741 {source="Europe PMC"} +xref: PMID:20467214 {source="Europe PMC"} +is_a: CHEBI:72588 ! semisynthetic derivative +is_a: CHEBI:87631 ! statin + +[Term] +id: CHEBI:87635 +name: statin (synthetic) +namespace: chebi_ontology +def: "A statin which does not occur naturally and which is not obtained by chemical transformation of a naturally occurring statin." [] +subset: 3_STAR +synonym: "statins (synthetic)" RELATED [ChEBI] +synonym: "synthetic statin" RELATED [ChEBI] +synonym: "synthetic statins" RELATED [ChEBI] +xref: PMID:11464449 {source="Europe PMC"} +xref: PMID:1464741 {source="Europe PMC"} +xref: PMID:16059807 {source="Europe PMC"} +xref: PMID:20467214 {source="Europe PMC"} +is_a: CHEBI:87631 ! statin + +[Term] +id: CHEBI:87732 +name: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one +namespace: chebi_ontology +def: "A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group." [] +subset: 3_STAR +synonym: "4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one" EXACT IUPAC_NAME [IUPAC] +xref: LINCS:LSM-1405 +xref: PPDB:681 +is_a: CHEBI:37912 ! hydroxycoumarin +is_a: CHEBI:51867 ! methyl ketone +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H16O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJVWKTKQMONHTI-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "308.329" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "308.10486" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=CC2=C1C(=C(C(O2)=O)C(CC(C)=O)C3=CC=CC=C3)O" xsd:string + +[Term] +id: CHEBI:87737 +name: (R)-warfarin +namespace: chebi_ontology +alt_id: CHEBI:45582 +def: "A 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide)." [] +subset: 3_STAR +synonym: "(+)-warfarin" RELATED [ChEBI] +synonym: "(R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone" RELATED [ChemIDplus] +synonym: "(R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one" RELATED [ChemIDplus] +synonym: "4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one" RELATED [PDBeChem] +synonym: "Dextrowarfarin" RELATED [ChemIDplus] +xref: CAS:5543-58-8 {source="ChemIDplus"} +xref: PDBeChem:RWF +xref: PMID:21949493 {source="Europe PMC"} +xref: PMID:22493814 {source="Europe PMC"} +xref: PMID:24962085 {source="Europe PMC"} +xref: PMID:26142522 {source="Europe PMC"} +xref: PMID:26161443 {source="Europe PMC"} +xref: PMID:7354137 {source="Europe PMC"} +xref: Reaxys:4298023 {source="Reaxys"} +is_a: CHEBI:87732 ! 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one +relationship: is_conjugate_acid_of CHEBI:87743 ! (R)-warfarin(1-) +relationship: is_enantiomer_of CHEBI:87738 ! (S)-warfarin +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H16O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJVWKTKQMONHTI-OAHLLOKOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "308.329" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "308.10486" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=CC2=C1C(=C(C(O2)=O)[C@H](CC(C)=O)C3=CC=CC=C3)O" xsd:string + +[Term] +id: CHEBI:87738 +name: (S)-warfarin +namespace: chebi_ontology +alt_id: CHEBI:45816 +def: "A 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (S)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide)." [] +subset: 3_STAR +synonym: "(-)-Warfarin" RELATED [ChemIDplus] +synonym: "(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone" RELATED [ChemIDplus] +synonym: "4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one" EXACT IUPAC_NAME [IUPAC] +synonym: "4-hydroxy-3-[(1S)-3-oxo-1-phenylbutyl]-2H-chromen-2-one" RELATED [PDBeChem] +synonym: "levrowarfarin" RELATED [ChEBI] +xref: CAS:5543-57-7 {source="ChemIDplus"} +xref: LINCS:LSM-5404 +xref: PDBeChem:SWF +xref: PMID:21949493 {source="Europe PMC"} +xref: PMID:22493814 {source="Europe PMC"} +xref: PMID:24962085 {source="Europe PMC"} +xref: PMID:26142522 {source="Europe PMC"} +xref: PMID:26161443 {source="Europe PMC"} +xref: PMID:7354137 {source="Europe PMC"} +xref: Reaxys:4298024 {source="Reaxys"} +is_a: CHEBI:87732 ! 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one +relationship: is_conjugate_acid_of CHEBI:87744 ! (S)-warfarin(1-) +relationship: is_enantiomer_of CHEBI:87737 ! (R)-warfarin +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H16O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJVWKTKQMONHTI-HNNXBMFYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "308.329" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "308.10486" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=CC2=C1C(=C(C(O2)=O)[C@@H](CC(C)=O)C3=CC=CC=C3)O" xsd:string + +[Term] +id: CHEBI:87743 +name: (R)-warfarin(1-) +namespace: chebi_ontology +def: "An organic anion that is the conjugate base of (R)-warfarin, obtained by deprotonation of the hydroxy group." [] +subset: 3_STAR +synonym: "2-oxo-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-4-olate" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:25696 ! organic anion +relationship: is_conjugate_base_of CHEBI:87737 ! (R)-warfarin +relationship: is_enantiomer_of CHEBI:87744 ! (S)-warfarin(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H15O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/p-1/t15-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJVWKTKQMONHTI-OAHLLOKOSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "307.321" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.09758" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=CC2=C1C(=C(C(O2)=O)[C@H](CC(C)=O)C3=CC=CC=C3)[O-]" xsd:string + +[Term] +id: CHEBI:87744 +name: (S)-warfarin(1-) +namespace: chebi_ontology +def: "An organic anion that is the conjugate base of (S)-warfarin, obtained by deprotonation of the hydroxy group." [] +subset: 3_STAR +synonym: "2-oxo-3-[(1S)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-4-olate" EXACT IUPAC_NAME [IUPAC] +is_a: CHEBI:25696 ! organic anion +relationship: is_conjugate_base_of CHEBI:87738 ! (S)-warfarin +relationship: is_enantiomer_of CHEBI:87743 ! (R)-warfarin(1-) +property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H15O4" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/p-1/t15-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PJVWKTKQMONHTI-HNNXBMFYSA-M" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "307.321" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "307.09758" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC=CC2=C1C(=C(C(O2)=O)[C@@H](CC(C)=O)C3=CC=CC=C3)[O-]" xsd:string + [Term] id: CHEBI:88184 name: metal allergen @@ -20090,6 +39891,174 @@ synonym: "allergenic drug" RELATED [ChEBI] is_a: CHEBI:23888 ! drug is_a: CHEBI:50904 ! allergen +[Term] +id: CHEBI:8871 +name: risperidone +namespace: chebi_ontology +def: "A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2." [] +subset: 3_STAR +synonym: "3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one" EXACT IUPAC_NAME [IUPAC] +synonym: "Risperdal" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "risperidona" RELATED INN [ChemIDplus] +synonym: "risperidone" EXACT [IUPHAR] +synonym: "risperidone" RELATED INN [KEGG_DRUG] +synonym: "risperidone" RELATED INN [WHO_MedNet] +synonym: "risperidonum" RELATED INN [ChemIDplus] +synonym: "Risperin" RELATED BRAND_NAME [DrugBank] +synonym: "Rispolept" RELATED BRAND_NAME [DrugBank] +synonym: "Rispolin" RELATED BRAND_NAME [DrugBank] +synonym: "Sequinan" RELATED BRAND_NAME [DrugBank] +xref: Beilstein:4891881 {source="Beilstein"} +xref: CAS:106266-06-2 {source="ChemIDplus"} +xref: CAS:106266-06-2 {source="KEGG DRUG"} +xref: Drug_Central:2389 {source="DrugCentral"} +xref: DrugBank:DB00734 +xref: HMDB:HMDB0005020 +xref: KEGG:D00426 +xref: LINCS:LSM-3193 +xref: Patent:EP196132 +xref: Patent:US4804663 +xref: PMID:11229618 {source="Europe PMC"} +xref: PMID:11476125 {source="Europe PMC"} +xref: PMID:14687852 {source="Europe PMC"} +xref: PMID:14728058 {source="Europe PMC"} +xref: PMID:15096074 {source="Europe PMC"} +xref: PMID:17054229 {source="Europe PMC"} +xref: PMID:18545060 {source="Europe PMC"} +xref: PMID:18722468 {source="Europe PMC"} +xref: PMID:19412457 {source="Europe PMC"} +xref: PMID:20825390 {source="Europe PMC"} +xref: PMID:23327578 {source="Europe PMC"} +xref: Reaxys:4891881 {source="Reaxys"} +xref: Wikipedia:Risperidone +is_a: CHEBI:37143 ! organofluorine compound +is_a: CHEBI:38932 ! pyridopyrimidine +is_a: CHEBI:48585 ! heteroarylpiperidine +is_a: CHEBI:51545 ! 1,2-benzoxazoles +relationship: has_role CHEBI:37890 ! alpha-adrenergic antagonist +relationship: has_role CHEBI:37955 ! H1-receptor antagonist +relationship: has_role CHEBI:48279 ! serotonergic antagonist +relationship: has_role CHEBI:48561 ! dopaminergic antagonist +relationship: has_role CHEBI:65191 ! second generation antipsychotic +relationship: has_role CHEBI:76779 ! EC 3.4.21.26 (prolyl oligopeptidase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C23H27FN4O2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RAPZEAPATHNIPO-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "410.48450" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "410.21180" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12" xsd:string + +[Term] +id: CHEBI:8988 +name: SN-38 +namespace: chebi_ontology +def: "A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself." [] +subset: 3_STAR +synonym: "(4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "10-Hydroxy-7-ethylcamptothecin" RELATED [ChemIDplus] +synonym: "7-Ethyl-10-hydroxy-20(S)-camptothecin" RELATED [ChemIDplus] +synonym: "7-Ethyl-10-hydroxycamptothecin" RELATED [ChemIDplus] +synonym: "NK 012" RELATED [ChemIDplus] +synonym: "NK-012" RELATED [ChemIDplus] +synonym: "SN 38" RELATED [ChemIDplus] +synonym: "SN 38 lactone" RELATED [ChemIDplus] +synonym: "SN-38" EXACT [UniProt] +xref: CAS:86639-52-3 {source="ChemIDplus"} +xref: CAS:86639-52-3 {source="KEGG COMPOUND"} +xref: HMDB:HMDB0060510 +xref: KEGG:C11173 +xref: PDBeChem:RS4 +xref: PMID:23921491 {source="Europe PMC"} +xref: PMID:24194565 {source="Europe PMC"} +xref: PMID:24477982 {source="Europe PMC"} +xref: PMID:24494988 {source="Europe PMC"} +xref: PMID:24842785 {source="Europe PMC"} +xref: PMID:24990485 {source="Europe PMC"} +xref: PMID:25233635 {source="Europe PMC"} +xref: PMID:25910639 {source="Europe PMC"} +xref: PMID:25917289 {source="Europe PMC"} +xref: PMID:26080460 {source="Europe PMC"} +xref: PMID:26106073 {source="Europe PMC"} +xref: PMID:26330269 {source="Europe PMC"} +xref: PMID:26337772 {source="Europe PMC"} +xref: PMID:26381056 {source="Europe PMC"} +xref: PMID:26505475 {source="Europe PMC"} +xref: PMID:26518357 {source="Europe PMC"} +xref: PMID:26526067 {source="Europe PMC"} +xref: PMID:26529243 {source="Europe PMC"} +xref: PMID:26541586 {source="Europe PMC"} +xref: PMID:26656185 {source="Europe PMC"} +xref: PMID:26695118 {source="Europe PMC"} +xref: PMID:26728136 {source="Europe PMC"} +xref: PMID:31321449 {source="Europe PMC"} +xref: PMID:31707444 {source="Europe PMC"} +xref: PMID:31956782 {source="Europe PMC"} +xref: PMID:32032928 {source="Europe PMC"} +xref: PMID:32104495 {source="Europe PMC"} +xref: PMID:32385283 {source="Europe PMC"} +xref: PMID:32387182 {source="Europe PMC"} +xref: PMID:33125824 {source="Europe PMC"} +xref: PMID:33138058 {source="Europe PMC"} +xref: PMID:33475937 {source="Europe PMC"} +xref: PMID:33615176 {source="Europe PMC"} +xref: PMID:33774525 {source="Europe PMC"} +xref: PMID:33851564 {source="Europe PMC"} +xref: Reaxys:4829984 {source="Reaxys"} +xref: Wikipedia:SN-38 +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:33853 ! phenols +is_a: CHEBI:48626 ! pyranoindolizinoquinoline +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:49103 ! drug metabolite +relationship: has_role CHEBI:50276 ! EC 5.99.1.2 (DNA topoisomerase) inhibitor +relationship: has_role CHEBI:68495 ! apoptosis inducer +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C22H20N2O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FJHBVJOVLFPMQE-QFIPXVFZSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "392.411" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "392.13722" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC1=C2C=C(O)C=CC2=NC2=C1CN1C2=CC2=C(COC(=O)[C@]2(O)CC)C1=O" xsd:string + +[Term] +id: CHEBI:90318 +name: EC 6.4.1.1 (pyruvate carboxylase) inhibitor +namespace: chebi_ontology +def: "An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1)." [] +subset: 3_STAR +synonym: "EC 6.4.1.1 (pyruvate carboxylase) inhibitors" RELATED [ChEBI] +synonym: "EC 6.4.1.1 inhibitor" RELATED [ChEBI] +synonym: "EC 6.4.1.1 inhibitors" RELATED [ChEBI] +synonym: "pyruvate carboxylase (EC 6.4.1.1) inhibitor" RELATED [ChEBI] +synonym: "pyruvate carboxylase (EC 6.4.1.1) inhibitors" RELATED [ChEBI] +synonym: "pyruvate carboxylase inhibitor" RELATED [ChEBI] +synonym: "pyruvate carboxylase inhibitors" RELATED [ChEBI] +synonym: "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor" RELATED [ChEBI] +synonym: "pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors" RELATED [ChEBI] +synonym: "pyruvic carboxylase inhibitor" RELATED [ChEBI] +synonym: "pyruvic carboxylase inhibitors" RELATED [ChEBI] +xref: Wikipedia:Pyruvate_carboxylase +is_a: CHEBI:76824 ! EC 6.4.1.* (carboxylase) inhibitor + +[Term] +id: CHEBI:90688 +name: metformin(1+) +namespace: chebi_ontology +def: "A guanidinium ion obtained by monoprotonation of metformin." [] +subset: 3_STAR +synonym: "metformin cation" RELATED [ChEBI] +is_a: CHEBI:60251 ! guanidinium ion +relationship: is_conjugate_acid_of CHEBI:6801 ! metformin +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H12N5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)/p+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "XZWYZXLIPXDOLR-UHFFFAOYSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "130.172" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "130.10872" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(=N)NC(=N)N(C)C.[H+]" xsd:string + [Term] id: CHEBI:90710 name: receptor modulator @@ -20117,6 +40086,25 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "106.082" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "105.95989" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=O)(N(S(*)(=O)=O)*)*" xsd:string +[Term] +id: CHEBI:90895 +name: irinotecan(1+) +namespace: chebi_ontology +def: "An organic cation obtained by protonation of the tertiary amino group of irinotecan." [] +subset: 3_STAR +synonym: "1-[1-({[(4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl]oxy}carbonyl)piperidin-4-yl]piperidin-1-ium" EXACT IUPAC_NAME [IUPAC] +synonym: "irinotecan cation" RELATED [ChEBI] +is_a: CHEBI:25697 ! organic cation +is_a: CHEBI:35274 ! ammonium ion derivative +relationship: is_conjugate_acid_of CHEBI:80630 ! irinotecan +property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H39N4O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/p+1/t33-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "UWKQSNNFCGGAFS-XIFFEERXSA-O" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "587.687" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "587.28641" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=CC=C2C(=C1)C(=C3C(=N2)C=4N(C3)C(C5=C(C4)[C@](C(OC5)=O)(CC)O)=O)CC)OC(=O)N6CCC(CC6)[NH+]7CCCCC7" xsd:string + [Term] id: CHEBI:91007 name: aromatic carboxylate @@ -20132,6 +40120,75 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C([O-])=O" xsd:string +[Term] +id: CHEBI:91079 +name: purinergic receptor P2 antagonist +namespace: chebi_ontology +def: "An antagonist at purinergic P2 receptors" [] +subset: 3_STAR +synonym: "non-selective P2 purinergic antagonist" RELATED [ChEBI] +synonym: "non-selective P2 purinergic antagonists" RELATED [ChEBI] +synonym: "P2 antagonist" RELATED [ChEBI] +synonym: "P2 antagonists" RELATED [ChEBI] +synonym: "purinergic receptor P2 antagonists" RELATED [ChEBI] +xref: Wikipedia:Purinergic_receptor +is_a: CHEBI:48706 ! antagonist + +[Term] +id: CHEBI:9150 +name: simvastatin +namespace: chebi_ontology +alt_id: CHEBI:45577 +def: "A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug." [] +subset: 3_STAR +synonym: "(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate" EXACT IUPAC_NAME [IUPAC] +synonym: "2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one" RELATED [ChemIDplus] +synonym: "MK-733" RELATED [KEGG_DRUG] +synonym: "Simvastatin" EXACT [KEGG_DRUG] +synonym: "simvastatin" RELATED INN [DrugBank] +synonym: "Simvastatina" RELATED [ChemIDplus] +synonym: "Simvastatine" RELATED [ChemIDplus] +synonym: "Simvastatinum" RELATED [ChemIDplus] +synonym: "Zocor" RELATED [ChemIDplus] +xref: Beilstein:4768037 {source="Beilstein"} +xref: CAS:79902-63-9 {source="ChemIDplus"} +xref: CAS:79902-63-9 {source="KEGG DRUG"} +xref: Drug_Central:2445 {source="DrugCentral"} +xref: DrugBank:DB00641 +xref: HMDB:HMDB0005007 +xref: KEGG:D00434 +xref: LINCS:LSM-2492 +xref: Patent:EP33538 +xref: Patent:US4444784 +xref: PMID:11336576 {source="Europe PMC"} +xref: PMID:12827636 {source="Europe PMC"} +xref: PMID:14561068 {source="Europe PMC"} +xref: PMID:14691614 {source="Europe PMC"} +xref: PMID:14973129 {source="Europe PMC"} +xref: PMID:16144183 {source="Europe PMC"} +xref: PMID:17640385 {source="Europe PMC"} +xref: PMID:18199328 {source="Europe PMC"} +xref: PMID:18688862 {source="Europe PMC"} +xref: PMID:18936176 {source="Europe PMC"} +xref: PMID:22737247 {source="Europe PMC"} +xref: Wikipedia:Simvastatin +is_a: CHEBI:142348 ! hexahydronaphthalenes +is_a: CHEBI:18946 ! delta-lactone +is_a: CHEBI:35748 ! fatty acid ester +is_a: CHEBI:87633 ! statin (semi-synthetic) +relationship: has_functional_parent CHEBI:40303 ! lovastatin +relationship: has_role CHEBI:173085 ! ferroptosis inducer +relationship: has_role CHEBI:176497 ! geroprotector +relationship: has_role CHEBI:50266 ! prodrug +relationship: has_role CHEBI:77255 ! EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C25H38O5" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RYMZZMVNJRMUDD-HGQWONQESA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "418.56620" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "418.27192" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12" xsd:string + [Term] id: CHEBI:9171 name: skatole @@ -20171,6 +40228,293 @@ property_value: http://purl.obolibrary.org/obo/chebi/mass "131.17450" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.07350" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/smiles "Cc1c[nH]c2ccccc12" xsd:string +[Term] +id: CHEBI:9334 +name: sulfasalazine +namespace: chebi_ontology +alt_id: CHEBI:101223 +def: "An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position." [] +subset: 3_STAR +synonym: "2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid" RELATED [ChemIDplus] +synonym: "2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid" RELATED [ChEMBL] +synonym: "2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid" EXACT IUPAC_NAME [IUPAC] +synonym: "4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene" RELATED [ChemIDplus] +synonym: "5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid" RELATED [ChemIDplus] +synonym: "5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid" RELATED [ChemIDplus] +synonym: "5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid" RELATED [ChemIDplus] +synonym: "Azulfidine" RELATED BRAND_NAME [KEGG_DRUG] +synonym: "Salazosulfapiridina" RELATED INN [ChemIDplus] +synonym: "Salazosulfapyridine" RELATED [KEGG_COMPOUND] +synonym: "Salazosulfapyridinum" RELATED INN [ChemIDplus] +synonym: "Salicylazosulfapyridine" RELATED [KEGG_COMPOUND] +synonym: "Sulfasalazina" RELATED INN [ChemIDplus] +synonym: "Sulfasalazine" EXACT [KEGG_COMPOUND] +synonym: "sulfasalazine" RELATED INN [ChemIDplus] +synonym: "Sulfasalazinum" RELATED INN [ChemIDplus] +xref: Beilstein:356241 {source="Beilstein"} +xref: Beilstein:8132868 {source="Beilstein"} +xref: CAS:599-79-1 {source="ChemIDplus"} +xref: CAS:599-79-1 {source="KEGG COMPOUND"} +xref: DrugBank:DB00795 +xref: Gmelin:2666050 {source="Gmelin"} +xref: KEGG:C07316 +xref: KEGG:D00448 +xref: Patent:US2396145 +xref: PDBeChem:SAS +xref: PMID:11362329 {source="Europe PMC"} +xref: PMID:11485124 {source="Europe PMC"} +xref: PMID:11587223 {source="Europe PMC"} +xref: PMID:14981898 {source="Europe PMC"} +xref: PMID:15248210 {source="Europe PMC"} +xref: PMID:16322111 {source="Europe PMC"} +xref: PMID:17386570 {source="Europe PMC"} +xref: PMID:2434548 {source="Europe PMC"} +xref: PMID:7720170 {source="Europe PMC"} +xref: Reaxys:8132868 {source="Reaxys"} +is_a: CHEBI:22682 ! azobenzenes +is_a: CHEBI:26421 ! pyridines +is_a: CHEBI:35358 ! sulfonamide +relationship: has_functional_parent CHEBI:45373 ! sulfanilamide +relationship: has_role CHEBI:173085 ! ferroptosis inducer +relationship: has_role CHEBI:35441 ! antiinfective agent +relationship: has_role CHEBI:35475 ! non-steroidal anti-inflammatory drug +relationship: has_role CHEBI:55324 ! gastrointestinal drug +relationship: has_role CHEBI:76797 ! EC 2.5.1.18 (glutathione transferase) inhibitor +relationship: has_role CHEBI:88188 ! drug allergen +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C18H14N4O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NCEXYHBECQHGNR-QZQOTICOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "398.39300" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "398.06849" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(=O)c1cc(ccc1O)\\N=N\\c1ccc(cc1)S(=O)(=O)Nc1ccccn1" xsd:string + +[Term] +id: CHEBI:9398 +name: tamsulosin +namespace: chebi_ontology +def: "A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones." [] +subset: 3_STAR +synonym: "(-)-tamsulosin" RELATED [ChEBI] +synonym: "(R)-(-)-tamsulosin" RELATED [ChEBI] +synonym: "(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide" RELATED [ChemIDplus] +synonym: "5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide" EXACT IUPAC_NAME [IUPAC] +synonym: "Tamsulosin" EXACT [KEGG_COMPOUND] +synonym: "tamsulosin" RELATED INN [ChemIDplus] +synonym: "tamsulosina" RELATED INN [ChemIDplus] +synonym: "tamsulosine" RELATED INN [ChemIDplus] +synonym: "tamsulosinum" RELATED INN [ChemIDplus] +xref: Beilstein:6896059 {source="Beilstein"} +xref: CAS:106133-20-4 {source="ChemIDplus"} +xref: CAS:106133-20-4 {source="KEGG COMPOUND"} +xref: Drug_Central:2562 {source="DrugCentral"} +xref: DrugBank:DB00706 +xref: KEGG:C07124 +xref: KEGG:D08560 +xref: Patent:EP34432 +xref: Patent:US4703063 +xref: PMID:2891044 {source="Europe PMC"} +xref: PMID:29728928 {source="Europe PMC"} +xref: PMID:29737501 {source="Europe PMC"} +xref: PMID:29913020 {source="Europe PMC"} +xref: PMID:29971698 {source="Europe PMC"} +xref: PMID:29974124 {source="Europe PMC"} +xref: PMID:30174141 {source="Europe PMC"} +xref: PMID:30360332 {source="Europe PMC"} +xref: Reaxys:6896059 {source="Reaxys"} +xref: Wikipedia:Tamsulosin +is_a: CHEBI:142546 ! 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide +relationship: has_role CHEBI:35610 ! antineoplastic agent +relationship: has_role CHEBI:37890 ! alpha-adrenergic antagonist +relationship: is_conjugate_base_of CHEBI:142544 ! tamsulosin(1+) +relationship: is_enantiomer_of CHEBI:142548 ! ent-tamsulosin +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H28N2O5S" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DRHKJLXJIQTDTD-OAHLLOKOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "408.514" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "408.17189" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1C=C(OCCN[C@@H](CC2=CC=C(C(=C2)S(N)(=O)=O)OC)C)C(=CC1)OCC" xsd:string + +[Term] +id: CHEBI:9448 +name: terbinafine +namespace: chebi_ontology +def: "A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections." [] +subset: 3_STAR +synonym: "(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine" EXACT IUPAC_NAME [IUPAC] +synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine" RELATED [ChemIDplus] +synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus] +synonym: "terbinafina" RELATED INN [WHO_MedNet] +synonym: "terbinafine" EXACT [WHO_MedNet] +synonym: "terbinafine" RELATED INN [KEGG_DRUG] +synonym: "terbinafinum" RELATED INN [WHO_MedNet] +xref: CAS:91161-71-6 {source="ChemIDplus"} +xref: CAS:91161-71-6 {source="KEGG COMPOUND"} +xref: Drug_Central:2597 {source="DrugCentral"} +xref: DrugBank:DB00857 +xref: HMDB:HMDB0014995 +xref: KEGG:C08079 +xref: KEGG:D02375 +xref: MetaCyc:CPD-10571 +xref: PMID:23750489 {source="Europe PMC"} +xref: PMID:23802806 {source="Europe PMC"} +xref: PMID:23841559 {source="Europe PMC"} +xref: PMID:23895037 {source="Europe PMC"} +xref: PMID:24126579 {source="Europe PMC"} +xref: PMID:24352873 {source="Europe PMC"} +xref: PMID:24389279 {source="Europe PMC"} +xref: PMID:24410098 {source="Europe PMC"} +xref: PMID:24447130 {source="Europe PMC"} +xref: PMID:24452843 {source="Europe PMC"} +xref: PMID:24477462 {source="Europe PMC"} +xref: PMID:24490976 {source="Europe PMC"} +xref: PMID:24497012 {source="Europe PMC"} +xref: PMID:24533442 {source="Europe PMC"} +xref: PMID:24563892 {source="Europe PMC"} +xref: PMID:24576265 {source="Europe PMC"} +xref: PMID:24581620 {source="Europe PMC"} +xref: PMID:24588014 {source="Europe PMC"} +xref: Reaxys:4256376 {source="Reaxys"} +xref: Wikipedia:Terbinafine +is_a: CHEBI:25477 ! naphthalenes +is_a: CHEBI:32876 ! tertiary amine +is_a: CHEBI:59831 ! enyne +is_a: CHEBI:87127 ! allylamine antifungal drug +relationship: has_role CHEBI:50183 ! P450 inhibitor +relationship: has_role CHEBI:59285 ! EC 1.14.13.132 (squalene monooxygenase) inhibitor +relationship: has_role CHEBI:83317 ! sterol biosynthesis inhibitor +relationship: is_conjugate_base_of CHEBI:77615 ! terbinafine(1+) +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H25N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DOMXUEMWDBAQBQ-WEVVVXLNSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "291.42990" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "291.19870" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CN(C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12" xsd:string + +[Term] +id: CHEBI:9588 +name: ticlopidine +namespace: chebi_ontology +def: "A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group." [] +subset: 3_STAR +synonym: "5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine" EXACT IUPAC_NAME [IUPAC] +synonym: "ticlopidina" RELATED INN [ChemIDplus] +synonym: "ticlopidine" RELATED INN [ChemIDplus] +synonym: "ticlopidine" RELATED INN [WHO_MedNet] +synonym: "ticlopidinum" RELATED INN [ChemIDplus] +xref: CAS:55142-85-3 {source="ChemIDplus"} +xref: Drug_Central:2657 {source="DrugCentral"} +xref: DrugBank:DB00208 +xref: KEGG:C07140 +xref: KEGG:D08594 +xref: LINCS:LSM-1986 +xref: Patent:DE2404308 +xref: Patent:US4051141 +xref: Patent:US4127580 +xref: PMID:19180126 {source="Europe PMC"} +xref: Reaxys:1216802 {source="Reaxys"} +xref: Wikipedia:Ticlopidine +is_a: CHEBI:37942 ! thienopyridine +is_a: CHEBI:83403 ! monochlorobenzenes +relationship: has_role CHEBI:48676 ! fibrin modulating drug +relationship: has_role CHEBI:50249 ! anticoagulant +relationship: has_role CHEBI:50427 ! platelet aggregation inhibitor +relationship: has_role CHEBI:68563 ! P2Y12 receptor antagonist +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C14H14ClNS" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PHWBOXQYWZNQIN-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "263.78600" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "263.05355" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "Clc1ccccc1CN1CCc2sccc2C1" xsd:string + +[Term] +id: CHEBI:9667 +name: triamcinolone +namespace: chebi_ontology +def: "A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. Used in the form of its 16,17-acetonide to treat various skin infections." [] +subset: 3_STAR +synonym: "(11beta,16alpha)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione" EXACT IUPAC_NAME [IUPAC] +synonym: "11beta,16alpha,17alpha,21-tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione" RELATED [ChemIDplus] +synonym: "9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione" RELATED [ChemIDplus] +synonym: "9alpha-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione" RELATED [ChemIDplus] +synonym: "9alpha-fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione" RELATED [NIST_Chemistry_WebBook] +synonym: "9alpha-fluoro-16alpha-hydroxyprednisolone" RELATED [ChemIDplus] +synonym: "Fluoxyprednisolone" RELATED [ChemIDplus] +synonym: "triamcinolona" RELATED INN [DrugBank] +synonym: "triamcinolone" RELATED INN [WHO_MedNet] +synonym: "triamcinolone" RELATED INN [KEGG_DRUG] +synonym: "triamcinolonum" RELATED INN [DrugBank] +xref: CAS:124-94-7 {source="NIST Chemistry WebBook"} +xref: CAS:124-94-7 {source="ChemIDplus"} +xref: Drug_Central:2725 {source="DrugCentral"} +xref: DrugBank:DB00620 +xref: HMDB:HMDB0014758 +xref: KEGG:D00385 +xref: Patent:WO2005028495 +xref: PMID:11583068 {source="Europe PMC"} +xref: PMID:15305946 {source="Europe PMC"} +xref: PMID:19668443 {source="Europe PMC"} +xref: PMID:22846803 {source="Europe PMC"} +xref: PMID:23151875 {source="Europe PMC"} +xref: PMID:23337526 {source="Europe PMC"} +xref: PMID:23370580 {source="Europe PMC"} +xref: PMID:23440982 {source="Europe PMC"} +xref: PMID:23449717 {source="Europe PMC"} +xref: PMID:23473287 {source="Europe PMC"} +xref: PMID:23562859 {source="Europe PMC"} +xref: PMID:7509503 {source="Europe PMC"} +xref: Reaxys:2341955 {source="Reaxys"} +xref: Wikipedia:Triamcinolone +is_a: CHEBI:139590 ! primary alpha-hydroxy ketone +is_a: CHEBI:139592 ! tertiary alpha-hydroxy ketone +is_a: CHEBI:16799 ! 16alpha-hydroxy steroid +is_a: CHEBI:24261 ! glucocorticoid +is_a: CHEBI:35342 ! 17alpha-hydroxy steroid +is_a: CHEBI:35344 ! 21-hydroxy steroid +is_a: CHEBI:35346 ! 11beta-hydroxy steroid +is_a: CHEBI:36885 ! 20-oxo steroid +is_a: CHEBI:47909 ! 3-oxo-Delta(4) steroid +is_a: CHEBI:50830 ! fluorinated steroid +is_a: CHEBI:64600 ! C21-steroid hormone +relationship: has_parent_hydride CHEBI:8386 ! pregnane +relationship: has_role CHEBI:35472 ! anti-inflammatory drug +relationship: has_role CHEBI:50857 ! anti-allergic agent +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C21H27FO6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "GFNANZIMVAIWHM-OBYCQNJPSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "394.43390" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "394.17917" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C" xsd:string + +[Term] +id: CHEBI:9747 +name: Triptolide +namespace: chebi_ontology +subset: 2_STAR +synonym: "Triptolide" EXACT [KEGG_COMPOUND] +xref: CAS:38748-32-2 {source="KEGG COMPOUND"} +xref: KEGG:C09204 +xref: KNApSAcK:C00003494 +xref: LINCS:LSM-5518 +xref: Wikipedia:Triptolide +is_a: CHEBI:23849 ! diterpenoid +is_a: CHEBI:32955 ! epoxide +is_a: CHEBI:52157 ! organic heteroheptacyclic compound +is_a: CHEBI:74222 ! gamma-lactam +relationship: has_role CHEBI:145047 ! antispermatogenic agent +relationship: has_role CHEBI:76924 ! plant metabolite +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C20H24O6" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DFBIRQPKNDILPW-CIVMWXNOSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "360.402" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.15729" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O" xsd:string + [Term] id: CHEBI:9937 name: vasopressin @@ -20200,6 +40544,52 @@ property_value: http://purl.obolibrary.org/obo/chebi/formula "C46H65N15O12S2.C46 property_value: http://purl.obolibrary.org/obo/chebi/mass "2140.458" xsd:string property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "2138.86956" xsd:string +[Term] +id: CHEBI:9943 +name: venlafaxine +namespace: chebi_ontology +def: "A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group." [] +subset: 3_STAR +synonym: "1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol" EXACT IUPAC_NAME [IUPAC] +synonym: "Elafax" RELATED [ChemIDplus] +synonym: "venlafaxina" RELATED INN [WHO_MedNet] +synonym: "Venlafaxine" EXACT [KEGG_COMPOUND] +synonym: "venlafaxine" RELATED INN [WHO_MedNet] +synonym: "venlafaxine" RELATED INN [ChemIDplus] +synonym: "venlafaxinum" RELATED INN [WHO_MedNet] +xref: Beilstein:4234848 {source="Beilstein"} +xref: CAS:93413-69-5 {source="ChemIDplus"} +xref: CAS:93413-69-5 {source="KEGG COMPOUND"} +xref: Drug_Central:2813 {source="DrugCentral"} +xref: DrugBank:DB00285 +xref: HMDB:HMDB0005016 +xref: KEGG:C07187 +xref: KEGG:D08670 +xref: LINCS:LSM-1616 +xref: PMID:11098420 {source="Europe PMC"} +xref: PMID:12409680 {source="Europe PMC"} +xref: PMID:18321472 {source="Europe PMC"} +xref: Reaxys:4234848 {source="Reaxys"} +xref: Wikipedia:Venlafaxine +is_a: CHEBI:23480 ! cyclohexanols +is_a: CHEBI:25235 ! monomethoxybenzene +is_a: CHEBI:26878 ! tertiary alcohol +is_a: CHEBI:50996 ! tertiary amino compound +relationship: has_role CHEBI:35469 ! antidepressant +relationship: has_role CHEBI:35480 ! analgesic +relationship: has_role CHEBI:35640 ! adrenergic uptake inhibitor +relationship: has_role CHEBI:35703 ! xenobiotic +relationship: has_role CHEBI:50949 ! serotonin uptake inhibitor +relationship: has_role CHEBI:51039 ! dopamine uptake inhibitor +relationship: has_role CHEBI:78298 ! environmental contaminant +property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/formula "C17H27NO2" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/inchikey "PNVNVHUZROJLTJ-UHFFFAOYSA-N" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/mass "277.40182" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "277.20418" xsd:string +property_value: http://purl.obolibrary.org/obo/chebi/smiles "COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1" xsd:string + [Term] id: CL:0000000 name: cell @@ -20208,18 +40598,23 @@ def: "A material entity of anatomical origin (part of or deriving from an organi comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 +xref: FBbt:00007002 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 +xref: MESH:D002477 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 +is_a: CARO:0000003 ! connected anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex disjoint_from: GO:0043226 ! organelle +relationship: directly_develops_from CL:0000000 ! cell relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="bearer_of"} ! nucleus relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="bearer_of"} ! nucleus relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000003 @@ -20288,26 +40683,34 @@ intersection_of: capable_of GO:0017145 ! stem cell division id: CL:0000015 name: male germ cell namespace: cell +def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." [https://orcid.org/0000-0001-5208-3432, PMID:29462262] def: "Male germ cell is a germ cell that supports male gamete production." [https://orcid.org/0000-0001-5208-3432] xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 {is_inferred="true"} ! germ cell +intersection_of: CL:0000586 ! germ cell +intersection_of: capable_of GO:0007283 ! spermatogenesis +relationship: capable_of GO:0007283 ! spermatogenesis +property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/574 xsd:string [Term] id: CL:0000017 name: spermatocyte namespace: cell def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880] +def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:D013090] xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 xref: FMA:84049 xref: WBbt:0006799 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000015 {is_inferred="true"} ! male germ cell +intersection_of: CL:0000015 ! male germ cell +intersection_of: capable_of GO:0048137 ! spermatocyte division +relationship: capable_of GO:0048137 ! spermatocyte division relationship: develops_from CL:0000020 ! spermatogonium [Term] @@ -20315,6 +40718,7 @@ id: CL:0000018 name: spermatid namespace: cell def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860] +def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:D013087] synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 @@ -20322,15 +40726,23 @@ xref: EMAPA:31486 xref: FBbt:00004942 xref: FMA:72294 xref: WBbt:0006800 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000413 ! haploid cell +intersection_of: CL:0000015 ! male germ cell +intersection_of: bearer_of PATO:0001375 ! haploid +intersection_of: capable_of GO:0001675 ! acrosome assembly +intersection_of: capable_of GO:0007288 ! sperm axoneme assembly +intersection_of: capable_of GO:0007289 ! spermatid nucleus differentiation +relationship: capable_of GO:0001675 ! acrosome assembly +relationship: capable_of GO:0007288 ! sperm axoneme assembly +relationship: capable_of GO:0007289 ! spermatid nucleus differentiation relationship: develops_from CL:0000657 ! secondary spermatocyte [Term] id: CL:0000019 name: sperm namespace: cell +def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:D013094] def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] @@ -20341,7 +40753,6 @@ xref: CALOHA:TS-0949 xref: FBbt:00004954 xref: FMA:67338 xref: WBbt:0006798 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000408 {is_inferred="true"} ! male gamete relationship: develops_from CL:0000018 ! spermatid @@ -20350,13 +40761,20 @@ id: CL:0000020 name: spermatogonium namespace: cell def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900] +def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:D013093] synonym: "spermatogonial cell" EXACT [] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 +xref: FBbt:00004934 xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 ! male germ cell +intersection_of: CL:0000015 ! male germ cell +intersection_of: bearer_of PATO:0001394 ! diploid +intersection_of: bearer_of PATO:0001501 ! immature +relationship: bearer_of PATO:0001394 ! diploid +relationship: bearer_of PATO:0001501 ! immature [Term] id: CL:0000021 @@ -20367,6 +40785,19 @@ xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 {is_inferred="true"} ! germ cell +intersection_of: CL:0000586 ! germ cell +intersection_of: capable_of GO:0048477 ! oogenesis +relationship: capable_of GO:0048477 ! oogenesis + +[Term] +id: CL:0000022 +name: female germ line stem cell +namespace: cell +xref: FBbt:00004873 +is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell +is_a: CL:0000021 {is_inferred="true"} ! female germ cell +intersection_of: CL:0000021 ! female germ cell +intersection_of: capable_of GO:0017145 ! stem cell division [Term] id: CL:0000023 @@ -20378,9 +40809,22 @@ xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 xref: FMA:18644 +xref: MESH:D009865 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000548 ! animal cell +relationship: participates_in GO:0007143 ! female meiotic nuclear division + +[Term] +id: CL:0000024 +name: oogonial cell +def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] +xref: FMA:83673 +is_a: CL:0000021 {is_inferred="true"} ! female germ cell +intersection_of: CL:0000021 ! female germ cell +intersection_of: capable_of GO:0000278 ! mitotic cell cycle +relationship: capable_of GO:0000278 ! mitotic cell cycle +relationship: develops_from CL:0000670 ! primordial germ cell [Term] id: CL:0000025 @@ -20395,9 +40839,10 @@ xref: CALOHA:TS-2191 xref: FBbt:00057012 xref: FMA:67343 xref: MA:0000388 -is_a: CARO:0000000 ! anatomical entity +xref: MESH:D010063 is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte +relationship: participates_in GO:0007143 ! female meiotic nuclear division [Term] id: CL:0000027 @@ -20424,7 +40869,6 @@ id: CL:0000030 name: glioblast namespace: cell xref: FBbt:00005145 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000133 ! neurectodermal cell @@ -20439,17 +40883,19 @@ xref: BTO:0000930 xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000548 ! animal cell -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000034 name: stem cell namespace: cell +def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872] comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. synonym: "animal stem cell" EXACT [] xref: CALOHA:TS-2086 xref: FMA:63368 +is_a: CL:0000548 ! animal cell is_a: CL:0011115 ! precursor cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0017145 ! stem cell division @@ -20474,6 +40920,7 @@ relationship: bearer_of PATO:0001400 ! unipotent id: CL:0000036 name: epithelial fate stem cell namespace: cell +synonym: "epithelial stem cell" EXACT [] is_a: CL:0000035 ! single fate stem cell [Term] @@ -20490,6 +40937,7 @@ xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 xref: FMA:86475 +xref: MESH:D006412 xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell @@ -20547,7 +40995,6 @@ namespace: cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: ubprop:upper_level -is_a: BFO:0000040 ! material entity is_a: CL:0000003 ! native cell disjoint_from: CL:0002371 ! somatic cell relationship: capable_of GO:0022414 ! reproductive process @@ -20588,8 +41035,8 @@ synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell +is_a: CL:0002319 ! neural cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000133 ! neurectodermal cell @@ -20685,6 +41132,7 @@ namespace: cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 +xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] @@ -20702,6 +41150,7 @@ is_a: CL:0011115 ! precursor cell id: CL:0000056 name: myoblast namespace: cell +def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:A11.635, PMID:21849021] xref: BTO:0000222 xref: CALOHA:TS-0650 @@ -20714,13 +41163,13 @@ is_a: CL:0000680 ! muscle precursor cell id: CL:0000057 name: fibroblast namespace: cell +def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: VHOG:0001482 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell @@ -20732,7 +41181,6 @@ def: "Skeletogenic cell that is typically non-terminally differentiated, secrete synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast @@ -20744,6 +41192,7 @@ name: ameloblast namespace: cell alt_id: CL:0000053 alt_id: CL:0000139 +def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:D000565] def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107] comment: non-encoded relationship from VSAO produces VSAO:0000066 synonym: "amelocyte" EXACT [] @@ -20753,13 +41202,35 @@ xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002077 ! ecto-epithelial cell +relationship: adjacent_to UBERON:0001763 ! odontogenic papilla +relationship: capable_of GO:0097186 ! amelogenesis relationship: develops_from CL:0007000 ! preameloblast +relationship: part_of UBERON:0005176 ! tooth enamel organ +relationship: produces UBERON:0001752 ! enamel + +[Term] +id: CL:0000060 +name: odontoblast +namespace: cell +def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256] +comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. +xref: BTO:0001769 +xref: CALOHA:TS-0696 +xref: FMA:62999 +is_a: CL:0000055 ! non-terminally differentiated cell +is_a: CL:0000710 ! neurecto-epithelial cell +is_a: CL:0002159 ! general ecto-epithelial cell +is_a: CL:0011026 ! progenitor cell +relationship: develops_from CL:0007003 ! preodontoblast +relationship: part_of UBERON:0005176 ! tooth enamel organ +relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000062 name: osteoblast namespace: cell def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629] +def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:D010006] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 xref: BTO:0001593 xref: CALOHA:TS-0720 @@ -20768,6 +41239,7 @@ is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0007010 ! preosteoblast +relationship: produces UBERON:0008883 ! osteoid [Term] id: CL:0000064 @@ -20781,11 +41253,23 @@ intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005929 ! cilium relationship: has_part GO:0005929 ! cilium +[Term] +id: CL:0000065 +name: ependymal cell +namespace: cell +def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134] +synonym: "ependymocyte" EXACT [] +xref: BTO:0001724 +xref: FMA:70550 +is_a: CL:0000067 ! ciliated epithelial cell +is_a: CL:0000710 ! neurecto-epithelial cell + [Term] id: CL:0000066 name: epithelial cell namespace: cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436] +def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 @@ -20793,7 +41277,6 @@ xref: CARO:0000077 xref: FBbt:00000124 xref: FMA:66768 xref: WBbt:0003672 -is_a: BFO:0000004 ! independent continuant is_a: CL:0000548 ! animal cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium @@ -20876,7 +41359,6 @@ is_a: CL:0002078 ! meso-epithelial cell id: CL:0000079 name: stratified epithelial cell namespace: cell -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell @@ -20886,7 +41368,6 @@ id: CL:0000080 name: circulating cell namespace: cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] -is_a: BFO:0000004 ! independent continuant is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid @@ -20898,7 +41379,7 @@ name: blood cell namespace: cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: FMA:62844 -is_a: BFO:0000040 ! material entity +xref: MESH:D001773 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: capable_of GO:0008015 ! blood circulation @@ -20911,7 +41392,6 @@ namespace: cell def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] synonym: "lung epithelial cell" EXACT [] xref: BTO:0004299 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002048 ! lung @@ -20925,10 +41405,12 @@ def: "An epithelial cell of the pancreas." [GOC:tfm] synonym: "pancreas epithelial cell" EXACT [] synonym: "pancreatic epithelial cell" EXACT [] xref: BTO:0000028 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000223 ! endodermal cell +relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000084 @@ -20945,18 +41427,19 @@ synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 +xref: MESH:D013601 xref: VHOG:0001479 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: capable_of GO:0002456 ! T cell mediated immunity +disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: capable_of GO:0002456 ! T cell mediated immunity relationship: develops_from CL:0000827 ! pro-T cell [Term] id: CL:0000091 name: Kupffer cell -namespace: cell -def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582] +def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:D007728, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] @@ -20971,13 +41454,13 @@ is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage [Term] id: CL:0000092 name: osteoclast -namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 +xref: MESH:D010010 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte @@ -20985,7 +41468,7 @@ intersection_of: capable_of GO:0045453 ! bone resorption intersection_of: has_part PR:000001850 ! cathepsin K intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: has_part PR:000001944 ! transcription factor PU.1 -intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos +intersection_of: has_part PR:000007597 ! protein c-Fos intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: part_of UBERON:0001474 ! bone element intersection_of: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A @@ -20995,7 +41478,7 @@ relationship: develops_from CL:0000576 ! monocyte relationship: has_part PR:000001850 ! cathepsin K relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 relationship: has_part PR:000001944 ! transcription factor PU.1 -relationship: has_part PR:000007597 ! proto-oncogene c-Fos +relationship: has_part PR:000007597 ! protein c-Fos relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit relationship: RO:0002104 PR:000001954 ! has plasma membrane part tumor necrosis factor receptor superfamily member 11A relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor @@ -21005,6 +41488,7 @@ id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098] +def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] @@ -21044,6 +41528,7 @@ relationship: develops_from CL:0000133 ! neurectodermal cell id: CL:0000097 name: mast cell namespace: cell +def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] @@ -21055,7 +41540,14 @@ xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell +relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response +relationship: capable_of GO:0002539 ! prostaglandin production involved in inflammatory response +relationship: capable_of GO:0002660 ! positive regulation of peripheral tolerance induction +relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis +relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response +relationship: capable_of GO:0030210 ! heparin biosynthetic process relationship: develops_from CL:0000831 ! mast cell progenitor +relationship: has_part GO:0030141 ! secretory granule [Term] id: CL:0000098 @@ -21075,6 +41567,7 @@ intersection_of: capable_of GO:0050906 ! detection of stimulus involved in senso id: CL:0000099 name: interneuron namespace: cell +def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358] xref: BTO:0003811 xref: FBbt:00005125 @@ -21087,8 +41580,10 @@ id: CL:0000100 name: motor neuron namespace: cell def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:A08.663.655.500, PMID:16875686] +def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] synonym: "motoneuron" EXACT [] xref: BTO:0000312 +xref: FBbt:00005123 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron @@ -21101,6 +41596,7 @@ def: "Any neuron having a sensory function; an afferent neuron conveying sensory xref: BTO:0001037 xref: FBbt:00005124 xref: FMA:84649 +xref: MESH:D011984 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron @@ -21123,15 +41619,17 @@ relationship: bearer_of PATO:0070006 ! cortical bipolar morphology id: CL:0000104 name: multipolar neuron namespace: cell -def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm] +def: "A neuron with three or more neurites, usually an axon and multiple dendrites." [FMA:67287, GOC:tfm] subset: BDS_subset xref: FMA:67287 is_a: CL:0000540 ! neuron +intersection_of: CL:0000540 ! neuron +intersection_of: bearer_of PATO:0070026 ! multipolar neuron morphology +relationship: bearer_of PATO:0070026 ! multipolar neuron morphology [Term] id: CL:0000107 name: autonomic neuron -namespace: cell def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron @@ -21146,6 +41644,7 @@ namespace: cell def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 +xref: MESH:D059329 xref: WBbt:0006840 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron @@ -21156,19 +41655,17 @@ relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: CL:0000109 name: adrenergic neuron -namespace: cell +xref: MESH:D059331 is_a: CL:0000540 ! neuron [Term] id: CL:0000110 name: peptidergic neuron -namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte -namespace: cell def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] xref: BTO:0001433 is_a: CL:0000226 ! single nucleate cell @@ -21204,6 +41701,20 @@ is_a: CL:0000540 ! neuron relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system +[Term] +id: CL:0000118 +name: basket cell +namespace: cell +def: "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." [WikipediaVersioned:Basket_cell&oldid=951703880] +subset: BDS_subset +is_a: CL:0000104 ! multipolar neuron +is_a: CL:0011005 ! GABAergic interneuron +intersection_of: CL:0000099 ! interneuron +intersection_of: bearer_of PATO:0070002 ! basket cell morphology +intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission +relationship: bearer_of PATO:0070002 ! basket cell morphology +property_value: created_by https://orcid.org/0000-0002-2825-0621 xsd:string + [Term] id: CL:0000119 name: cerebellar Golgi cell @@ -21213,7 +41724,11 @@ synonym: "cerebellar Golgi neuron" EXACT [] synonym: "cerebellum Golgi cell" EXACT [] synonym: "Golgi cell" EXACT [] synonym: "Golgi neuron" EXACT [] +xref: MESH:D000080906 +is_a: CL:0000402 ! CNS interneuron is_a: CL:0011005 ! GABAergic interneuron +is_a: CL:1001611 ! cerebellar neuron +relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] id: CL:0000120 @@ -21225,8 +41740,7 @@ is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell -namespace: cell -def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600] +def: "The output neuron of the cerebellar cortex." [MESH:D011689] synonym: "cerebellar Purkinje cell" EXACT [] synonym: "cerebellum Purkinje cell" EXACT [] synonym: "Purkinje neuron" EXACT [] @@ -21244,17 +41758,20 @@ name: neuron associated cell (sensu Vertebrata) namespace: cell is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000333 ! migratory neural crest cell -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000125 name: glial cell namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637] +def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] +comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 +xref: FBbt:00005144 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 {comment="It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation."} ! glioblast @@ -21275,6 +41792,7 @@ relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) id: CL:0000127 name: astrocyte namespace: cell +def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. synonym: "astrocytic glia" EXACT [] @@ -21286,8 +41804,7 @@ is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte -namespace: cell -def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836] +def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] @@ -21295,15 +41812,15 @@ xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 {is_inferred="true"} ! macroglial cell +is_a: CL:4023154 ! myelinating glial cell relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000129 name: microglial cell -namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] -comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. +comment: Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. {xref="PMID:23616747"} synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] @@ -21316,7 +41833,7 @@ xref: FMA:54539 xref: FMA:54540 is_a: CL:0000125 ! glial cell is_a: CL:0000878 ! central nervous system macrophage -relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell +relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000133 @@ -21331,6 +41848,7 @@ id: CL:0000134 name: mesenchymal stem cell namespace: cell alt_id: CL:0002452 +def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. synonym: "BMSC" NARROW [] @@ -21355,7 +41873,6 @@ property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/474 [Term] id: CL:0000135 name: fibrocyte -namespace: cell def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. xref: FMA:63879 @@ -21368,12 +41885,12 @@ name: fat cell namespace: cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114] +def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] synonym: "adipocyte" EXACT [] synonym: "adipose cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell @@ -21381,15 +41898,13 @@ relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000137 name: osteocyte -namespace: cell -def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500] +def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:D010011] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0001035 ! bone cell relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast @@ -21397,6 +41912,7 @@ relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblas id: CL:0000138 name: chondrocyte namespace: cell +def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171] synonym: "cartilage cell" EXACT [] xref: BTO:0000249 @@ -21445,8 +41961,8 @@ synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 +xref: MESH:D008544 xref: VHOG:0001679 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000147 {is_inferred="true"} ! pigment cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000147 ! pigment cell @@ -21481,7 +41997,6 @@ namespace: cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: BTO:0003659 xref: FMA:86916 -is_a: BFO:0000040 ! material entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0032940 ! secretion by cell @@ -21536,6 +42051,9 @@ name: surfactant secreting cell namespace: cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 {is_inferred="true"} ! secretory cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0043129 ! surfactant homeostasis +relationship: capable_of GO:0043129 ! surfactant homeostasis [Term] id: CL:0000158 @@ -21549,6 +42067,13 @@ xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell +intersection_of: CL:0002328 ! bronchial epithelial cell +intersection_of: bearer_of PATO:0001789 ! domed +intersection_of: capable_of GO:0032940 ! secretion by cell +intersection_of: capable_of GO:0043129 ! surfactant homeostasis +intersection_of: RO:0002104 GO:0005902 ! has plasma membrane part microvillus +relationship: bearer_of PATO:0001789 ! domed +relationship: RO:0002104 GO:0005902 ! has plasma membrane part microvillus [Term] id: CL:0000159 @@ -21560,6 +42085,7 @@ is_a: CL:0000151 ! secretory cell id: CL:0000160 name: goblet cell namespace: cell +def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:D020397] def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320] synonym: "chalice cell" EXACT [] xref: BTO:0001540 @@ -21592,6 +42118,7 @@ is_a: CL:0002659 ! glandular cell of stomach id: CL:0000163 name: endocrine cell namespace: cell +def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 @@ -21608,6 +42135,7 @@ namespace: cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] xref: BTO:0003865 xref: FMA:62930 +xref: MESH:D019858 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell @@ -21616,6 +42144,7 @@ id: CL:0000165 name: neuroendocrine cell namespace: cell def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688] +def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:D055099] synonym: "neurosecretory cell" EXACT [] xref: BTO:0002691 xref: FMA:83810 @@ -21628,6 +42157,7 @@ id: CL:0000166 name: chromaffin cell namespace: cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161] +def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:D019439] synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 @@ -21650,6 +42180,9 @@ namespace: cell xref: BTO:0000783 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0030073 ! insulin secretion +relationship: capable_of GO:0030073 ! insulin secretion [Term] id: CL:0000169 @@ -21676,7 +42209,11 @@ is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 {is_inferred="true"} ! enteroendocrine cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: capable_of GO:0030073 ! insulin secretion +intersection_of: part_of UBERON:0000006 ! islet of Langerhans relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas +relationship: part_of UBERON:0000006 ! islet of Langerhans [Term] id: CL:0000170 @@ -21699,10 +42236,14 @@ synonym: "alpha cell of islet of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 +xref: MESH:D050416 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0002067 ! type A enteroendocrine cell +intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas +relationship: part_of UBERON:0000006 ! islet of Langerhans [Term] id: CL:0000172 @@ -21729,7 +42270,10 @@ xref: FMA:70587 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas +relationship: part_of UBERON:0000006 ! islet of Langerhans [Term] id: CL:0000174 @@ -21740,11 +42284,26 @@ intersection_of: CL:0000151 ! secretory cell intersection_of: capable_of GO:0035929 ! steroid hormone secretion relationship: capable_of GO:0035929 ! steroid hormone secretion +[Term] +id: CL:0000175 +name: luteal cell +namespace: cell +def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400] +synonym: "lutein cell" EXACT [] +xref: BTO:0003939 +xref: FMA:18688 +is_a: CL:0000179 ! progesterone secreting cell +is_a: CL:0002132 ! stromal cell of ovary +relationship: part_of UBERON:0002512 ! corpus luteum + [Term] id: CL:0000177 name: testosterone secreting cell namespace: cell is_a: CL:0000151 ! secretory cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0035936 ! testosterone secretion +relationship: capable_of GO:0035936 ! testosterone secretion [Term] id: CL:0000178 @@ -21758,22 +42317,37 @@ xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 +xref: MESH:D007985 is_a: CL:0000177 ! testosterone secreting cell +relationship: develops_from CL:0009091 ! Leydig stem cell +relationship: part_of UBERON:0005212 ! Leydig cell region of testis + +[Term] +id: CL:0000179 +name: progesterone secreting cell +namespace: cell +is_a: CL:0000174 ! steroid hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0042701 ! progesterone secretion +relationship: capable_of GO:0042701 ! progesterone secretion [Term] id: CL:0000182 name: hepatocyte namespace: cell +def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0000417 ! endopolyploid cell is_a: CL:0002371 ! somatic cell +relationship: capable_of GO:0006699 ! bile acid biosynthetic process +relationship: capable_of GO:0098754 ! detoxification relationship: develops_from CL:0005026 ! hepatoblast +relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000183 @@ -21796,10 +42370,22 @@ is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell is_a: CL:0002078 ! meso-epithelial cell +[Term] +id: CL:0000186 +name: myofibroblast cell +namespace: cell +def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469] +comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. +synonym: "MFB" EXACT [PMID:8731193] +is_a: CL:0000183 ! contractile cell +is_a: CL:0000548 ! animal cell +is_a: CL:0002371 ! somatic cell + [Term] id: CL:0000187 name: muscle cell namespace: cell +def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] @@ -21809,7 +42395,6 @@ xref: CALOHA:TS-2032 xref: FBbt:00005074 xref: FMA:67328 xref: WBbt:0003675 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell @@ -21825,7 +42410,6 @@ synonym: "skeletal muscle cell" EXACT [] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002371 ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue @@ -21834,7 +42418,6 @@ relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000189 name: slow muscle cell -namespace: cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] synonym: "slow muscle fiber" RELATED [ISBN:0815316208] xref: FMA:84448 @@ -21844,8 +42427,7 @@ relationship: develops_from CL:0000857 ! slow muscle myoblast [Term] id: CL:0000190 name: fast muscle cell -namespace: cell -def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908] +def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron." [GOC:tfm, ISBN:0323052908] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0008046 ! extrafusal muscle fiber relationship: develops_from CL:0000858 ! fast muscle myoblast @@ -21855,6 +42437,7 @@ id: CL:0000192 name: smooth muscle cell namespace: cell alt_id: CL:0000191 +def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361] synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" BROAD [] @@ -21873,7 +42456,7 @@ name: sensory receptor cell namespace: cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] synonym: "receptor cell" EXACT [] -is_a: BFO:0000040 ! material entity +xref: MESH:D011984 is_a: CL:0000003 ! native cell intersection_of: CL:0000000 ! cell intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception @@ -21884,8 +42467,7 @@ relationship: part_of UBERON:0001032 ! sensory system [Term] id: CL:0000198 name: pain receptor cell -namespace: cell -def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650] +def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:D009619] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] @@ -21896,15 +42478,18 @@ id: CL:0000199 name: mechanoreceptor cell namespace: cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500] +def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:D008465] synonym: "mechanoreceptor" RELATED [MP:0000972] is_a: CL:0000101 ! sensory neuron +intersection_of: CL:0000540 ! neuron +intersection_of: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: capable_of GO:0050974 ! detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000202 name: auditory hair cell -namespace: cell alt_id: CL:0000201 -def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250, WikipediaVersioned:Hair_cell&oldid=1045345915] +def: "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:D006198, WikipediaVersioned:Hair_cell&oldid=1045345915] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" RELATED [] xref: FMA:62364 @@ -21913,14 +42498,14 @@ is_a: CL:0000855 ! sensory hair cell [Term] id: CL:0000205 name: thermoreceptor cell -namespace: cell -def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971] +def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:D013823, MP:0000971] is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000206 name: chemoreceptor cell namespace: cell +def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120] is_a: CL:0000101 ! sensory neuron intersection_of: CL:0000540 ! neuron @@ -21937,9 +42522,14 @@ synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 +xref: MESH:D018034 xref: Wikipedia:Olfactory_receptor_neuron is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000206 ! chemoreceptor cell +intersection_of: CL:0000540 ! neuron +intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: part_of UBERON:0005725 ! olfactory system [Term] id: CL:0000209 @@ -21963,6 +42553,7 @@ id: CL:0000210 name: photoreceptor cell namespace: cell def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650] +def: "A cell specialized to detect and transduce light." [MESH:D010786] xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 @@ -21982,7 +42573,6 @@ is_a: CL:0000003 ! native cell [Term] id: CL:0000212 name: absorptive cell -namespace: cell def: "A cell that takes up and metabolizes substances." [CL:CVS] is_a: CL:0000003 ! native cell @@ -21998,18 +42588,12 @@ is_a: CL:0000215 ! barrier cell id: CL:0000214 name: synovial cell namespace: cell -def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474] -synonym: "hyaluronic acid secreting cell" NARROW [] +def: "A cell located in the synovial joint." [] synonym: "synoviocyte" EXACT [] -xref: BTO:0003652 xref: CALOHA:TS-0995 -xref: FMA:66786 -is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell -intersection_of: CL:0002078 ! meso-epithelial cell -intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint -relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint +relationship: part_of UBERON:0002217 ! synovial joint [Term] id: CL:0000215 @@ -22022,6 +42606,7 @@ is_a: CL:0000003 ! native cell id: CL:0000216 name: Sertoli cell namespace: cell +def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:D012708] def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789] xref: BTO:0001238 xref: CALOHA:TS-0922 @@ -22030,26 +42615,26 @@ xref: VHOG:0001348 is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 {is_inferred="true"} ! supporting cell is_a: CL:0002625 ! seminiferous tubule epithelial cell +intersection_of: CL:0000630 ! supporting cell +intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] id: CL:0000217 name: insulating cell -namespace: cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell -namespace: cell -def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800] +def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:D012583] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0000217 ! insulating cell -is_a: CL:0000328 ! myelin accumulating cell is_a: CL:0002573 ! Schwann cell +is_a: CL:4023154 ! myelinating glial cell relationship: develops_from CL:0002377 ! immature Schwann cell [Term] @@ -22057,7 +42642,6 @@ id: CL:0000219 name: motile cell namespace: cell def: "A cell that moves by its own activities." [FB:ma] -is_a: BFO:0000040 ! material entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0048870 ! cell motility @@ -22067,10 +42651,10 @@ relationship: capable_of GO:0048870 ! cell motility id: CL:0000221 name: ectodermal cell namespace: cell +def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000924 ! ectoderm @@ -22078,11 +42662,11 @@ relationship: part_of UBERON:0000924 ! ectoderm id: CL:0000222 name: mesodermal cell namespace: cell +def: "A cell of the middle germ layer of the embryo." [MESH:D008648] def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000926 ! mesoderm @@ -22090,10 +42674,10 @@ relationship: part_of UBERON:0000926 ! mesoderm id: CL:0000223 name: endodermal cell namespace: cell +def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407] synonym: "endoderm cell" EXACT [] xref: FMA:72555 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002321 ! embryonic cell (metazoa) relationship: part_of UBERON:0000925 ! endoderm @@ -22123,7 +42707,6 @@ relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000227 name: binucleate cell -namespace: cell is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001406 ! binucleate @@ -22149,6 +42732,7 @@ id: CL:0000232 name: erythrocyte namespace: cell def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290] +def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 @@ -22172,6 +42756,7 @@ relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor pro id: CL:0000233 name: platelet namespace: cell +def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. synonym: "anucleate thrombocyte" EXACT [] @@ -22184,6 +42769,13 @@ is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell +intersection_of: CL:0000763 ! myeloid cell +intersection_of: bearer_of PATO:0001405 ! anucleate +intersection_of: bearer_of PATO:0001874 ! discoid +intersection_of: capable_of GO:0007596 ! blood coagulation +intersection_of: capable_of GO:0008015 ! blood circulation +relationship: bearer_of PATO:0001874 ! discoid +relationship: capable_of GO:0007596 ! blood coagulation relationship: develops_from CL:0000556 ! megakaryocyte [Term] @@ -22193,6 +42785,7 @@ namespace: cell def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] xref: BTO:0001044 xref: FMA:83806 +xref: MESH:D010586 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell @@ -22211,6 +42804,7 @@ xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 +xref: MESH:D008264 is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000234 ! phagocyte is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte @@ -22233,8 +42827,12 @@ synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 +xref: MESH:D001402 xref: VHOG:0001480 is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage +intersection_of: CL:0000945 ! lymphocyte of B lineage +intersection_of: capable_of GO:0019724 ! B cell mediated immunity +relationship: capable_of GO:0019724 ! B cell mediated immunity [Term] id: CL:0000237 @@ -22264,6 +42862,7 @@ id: CL:0000242 name: Merkel cell namespace: cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425] +def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:D018862] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) @@ -22271,10 +42870,20 @@ is_a: CL:0000312 {xref="PMID:19782676"} ! keratinocyte is_a: CL:0000710 ! neurecto-epithelial cell relationship: part_of UBERON:0002025 ! stratum basale of epidermis +[Term] +id: CL:0000244 +name: transitional epithelial cell +namespace: cell +def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] +xref: FMA:66778 +is_a: CL:0000066 ! epithelial cell +is_a: CL:0002371 ! somatic cell + [Term] id: CL:0000255 name: eukaryotic cell namespace: cell +xref: MESH:D005057 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: only_in_taxon NCBITaxon:2759 ! Eukaryota @@ -22283,7 +42892,6 @@ relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: CL:0000257 name: Eumycetozoan cell -namespace: cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000003 ! native cell intersection_of: only_in_taxon NCBITaxon:142796 ! Eumycetozoa @@ -22301,7 +42909,6 @@ relationship: part_of UBERON:0000970 ! eye [Term] id: CL:0000293 name: structural cell -namespace: cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000003 ! native cell @@ -22314,6 +42921,9 @@ def: "A peptide hormone secreting cell that produces growth hormone, somatotropi synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0030252 ! growth hormone secretion +relationship: capable_of GO:0030252 ! growth hormone secretion [Term] id: CL:0000300 @@ -22327,6 +42937,10 @@ xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell +intersection_of: CL:0000586 ! germ cell +intersection_of: bearer_of PATO:0001375 ! haploid +intersection_of: capable_of GO:0009566 ! fertilization +relationship: capable_of GO:0009566 ! fertilization [Term] id: CL:0000306 @@ -22336,6 +42950,22 @@ synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell +[Term] +id: CL:0000307 +name: tracheal epithelial cell +namespace: cell +alt_id: CL:1000474 +def: "An epithelial cell found in the trachea." [GOC:tfm] +comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' +synonym: "tracheocyte" EXACT [] +xref: FBbt:00005038 +xref: FMA:74793 +is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0003126 ! trachea +relationship: develops_from CL:0000377 ! tracheoblast +relationship: part_of UBERON:0003126 ! trachea + [Term] id: CL:0000311 name: keratin accumulating cell @@ -22348,13 +42978,13 @@ name: keratinocyte namespace: cell alt_id: CL:0002185 def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] +def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 -is_a: BFO:0000040 ! material entity is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell is_a: CL:0000362 {is_inferred="true"} ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell @@ -22374,14 +43004,23 @@ xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell +[Term] +id: CL:0000314 +name: milk secreting cell +namespace: cell +is_a: CL:0000151 ! secretory cell + [Term] id: CL:0000317 name: sebum secreting cell namespace: cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702] +def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:D012629] synonym: "sebocyte" EXACT [] is_a: CL:0000152 ! exocrine cell is_a: CL:2000021 ! sebaceous gland cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: part_of UBERON:0001821 ! sebaceous gland [Term] id: CL:0000319 @@ -22390,6 +43029,9 @@ namespace: cell synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0070254 ! mucus secretion +relationship: capable_of GO:0070254 ! mucus secretion [Term] id: CL:0000322 @@ -22402,11 +43044,11 @@ xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 is_a: CL:0010003 ! epithelial cell of alveolus of lung +relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium [Term] id: CL:0000323 name: lysozyme secreting cell -namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] @@ -22420,30 +43062,18 @@ is_a: CL:0000003 ! native cell [Term] id: CL:0000326 name: glycogen accumulating cell -namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell namespace: cell -is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell -intersection_of: CL:0000151 ! secretory cell -intersection_of: capable_of GO:0070278 ! extracellular matrix constituent secretion -relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion - -[Term] -id: CL:0000328 -name: myelin accumulating cell -namespace: cell -is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000329 name: oxygen accumulating cell namespace: cell -is_a: BFO:0000040 ! material entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0015671 ! oxygen transport @@ -22463,7 +43093,6 @@ relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell -namespace: cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell @@ -22477,7 +43106,10 @@ synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262] xref: FMA:69262 is_a: CL:0000457 ! biogenic amine secreting cell is_a: CL:1000426 ! chromaffin cell of adrenal gland +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: develops_from CL:0000011 ! migratory trunk neural crest cell +relationship: part_of UBERON:0001236 ! adrenal medulla [Term] id: CL:0000339 @@ -22493,9 +43125,7 @@ is_a: CL:0011026 ! progenitor cell [Term] id: CL:0000347 name: scleral cell -namespace: cell def: "A cell of the sclera of the eye." [GOC:add] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera @@ -22505,9 +43135,7 @@ relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye -namespace: cell def: "A cell of the choroid of the eye." [GOC:add] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid @@ -22518,7 +43146,6 @@ relationship: part_of UBERON:0001776 ! optic choroid id: CL:0000349 name: extraembryonic cell namespace: cell -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell @@ -22529,10 +43156,12 @@ relationship: part_of UBERON:0000478 ! extraembryonic structure id: CL:0000351 name: trophoblast cell namespace: cell +def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:D014327] def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell +relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 @@ -22541,6 +43170,25 @@ namespace: cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell +[Term] +id: CL:0000353 +name: blastoderm cell +namespace: cell +def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104] +def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] +synonym: "blastomere" EXACT [] +xref: BTO:0001473 +xref: FMA:72551 +is_a: CL:0000007 ! early embryonic cell (metazoa) + +[Term] +id: CL:0000354 +name: blastemal cell +namespace: cell +synonym: "blastema cell" EXACT [] +xref: ncithesaurus:Blastemal_Cell +is_a: CL:0000048 ! multi fate stem cell + [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell @@ -22559,6 +43207,16 @@ name: stratified epithelial stem cell namespace: cell is_a: CL:0000036 ! epithelial fate stem cell +[Term] +id: CL:0000358 +name: sphincter associated smooth muscle cell +namespace: cell +def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0004590 ! sphincter muscle +relationship: part_of UBERON:0004590 ! sphincter muscle + [Term] id: CL:0000359 name: vascular associated smooth muscle cell @@ -22582,6 +43240,7 @@ synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 +xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007376 ! outer epithelium @@ -22601,6 +43260,12 @@ is_a: CL:0010017 ! zygote intersection_of: CL:0010017 ! zygote intersection_of: only_in_taxon NCBITaxon:33208 ! Metazoa +[Term] +id: CL:0000377 +name: tracheoblast +namespace: cell +is_a: CL:0000069 ! branched duct epithelial cell + [Term] id: CL:0000381 name: neurosecretory neuron @@ -22622,7 +43287,6 @@ is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron -namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! has soma location ganglion @@ -22653,6 +43317,9 @@ xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000300 {is_inferred="true"} ! gamete +intersection_of: CL:0000015 ! male germ cell +intersection_of: bearer_of PATO:0001375 ! haploid +intersection_of: capable_of GO:0009566 ! fertilization [Term] id: CL:0000412 @@ -22667,6 +43334,9 @@ name: haploid cell namespace: cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: bearer_of PATO:0001375 ! haploid +relationship: bearer_of PATO:0001375 ! haploid [Term] id: CL:0000417 @@ -22677,15 +43347,22 @@ is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000424 name: excretory cell -namespace: cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135] xref: WBbt:0005812 is_a: CL:0000151 ! secretory cell +[Term] +id: CL:0000432 +name: reticular cell +namespace: cell +def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651] +synonym: "reticulum cell" EXACT [] +xref: FMA:62877 +is_a: CL:0000057 ! fibroblast + [Term] id: CL:0000437 name: gonadtroph -namespace: cell def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] @@ -22705,13 +43382,20 @@ name: luteinizing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] is_a: CL:0000163 ! endocrine cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0032275 ! luteinizing hormone secretion +relationship: capable_of GO:0032275 ! luteinizing hormone secretion [Term] id: CL:0000439 name: prolactin secreting cell namespace: cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] +is_a: CL:0000154 ! protein secreting cell is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0070459 ! prolactin secretion +relationship: capable_of GO:0070459 ! prolactin secretion [Term] id: CL:0000440 @@ -22722,11 +43406,13 @@ synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion +relationship: capable_of GO:0036160 ! melanocyte-stimulating hormone secretion [Term] id: CL:0000441 name: follicle stem cell -namespace: cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell @@ -22738,6 +43424,7 @@ def: "A cell with extensive dendritic processes found in the B cell areas (prima comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: BTO:0004267 xref: FMA:83037 +xref: MESH:D020566 is_a: CL:0000473 ! defensive cell [Term] @@ -22745,6 +43432,9 @@ id: CL:0000443 name: calcitonin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0036161 ! calcitonin secretion +relationship: capable_of GO:0036161 ! calcitonin secretion [Term] id: CL:0000446 @@ -22770,8 +43460,7 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell -namespace: cell -def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500] +def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:D052438] synonym: "white adipocyte" RELATED [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" EXACT [] @@ -22783,8 +43472,7 @@ relationship: develops_from CL:0002334 ! preadipocyte [Term] id: CL:0000449 name: brown fat cell -namespace: cell -def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322] +def: "A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:D002001] synonym: "brown adipocyte" EXACT [] synonym: "brown adipose cell" EXACT [] xref: CALOHA:TS-0099 @@ -22802,6 +43490,7 @@ synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 +xref: MESH:D003713 is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000738 ! leukocyte @@ -22829,7 +43518,6 @@ relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-doma [Term] id: CL:0000452 name: thyroid hormone secreting cell -namespace: cell is_a: CL:0000163 ! endocrine cell [Term] @@ -22843,8 +43531,10 @@ synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 +xref: MESH:D007801 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell +relationship: capable_of GO:0002828 ! regulation of type 2 immune response relationship: develops_from CL:0000763 ! myeloid cell [Term] @@ -22855,6 +43545,18 @@ def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from n synonym: "adrenaline secreting cell" EXACT [GO:0048242] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0048242 ! epinephrine secretion +relationship: capable_of GO:0048242 ! epinephrine secretion + +[Term] +id: CL:0000456 +name: mineralocorticoid secreting cell +namespace: cell +is_a: CL:0000174 ! steroid hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0035931 ! mineralocorticoid secretion +relationship: capable_of GO:0035931 ! mineralocorticoid secretion [Term] id: CL:0000457 @@ -22900,6 +43602,9 @@ synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] is_a: CL:0000163 ! endocrine cell is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0051458 ! corticotropin secretion +relationship: capable_of GO:0051458 ! corticotropin secretion [Term] id: CL:0000473 @@ -22911,25 +43616,39 @@ is_a: CL:0000003 ! native cell [Term] id: CL:0000476 name: thyrotroph -namespace: cell def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 +xref: MESH:D052684 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000477 -name: ovarian follicle cell -namespace: cell -def: "A somatic epithelial cell of the ovarian follicle/egg chamber." [] -comment: Editors note: check this. Currently used in goxp +name: follicle cell of egg chamber +def: "A somatic epithelial cell of the insect egg chamber." [] synonym: "follicle cell" BROAD [] +synonym: "ovarian follicle cell" BROAD [] xref: FBbt:00004904 +is_a: CL:0000500 ! follicular epithelial cell is_a: CL:2000064 ! ovarian surface epithelial cell relationship: develops_from CL:0000441 ! follicle stem cell +[Term] +id: CL:0000484 +name: connective tissue type mast cell +namespace: cell +def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] +comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. +synonym: "MC(TC)" EXACT [] +synonym: "MCTC" EXACT [] +synonym: "TC mast cells" EXACT [] +is_a: CL:0000097 {is_inferred="true"} ! mast cell +is_a: CL:0002320 ! connective tissue cell +intersection_of: CL:0000097 ! mast cell +intersection_of: part_of UBERON:0002384 ! connective tissue + [Term] id: CL:0000488 name: visible light photoreceptor cell @@ -22945,6 +43664,7 @@ id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400] +def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:D006377] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] @@ -22952,7 +43672,11 @@ synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell +intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell +intersection_of: capable_of GO:0001816 ! cytokine production +relationship: capable_of GO:0001816 ! cytokine production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell +relationship: has_completed GO:0030217 ! T cell differentiation [Term] id: CL:0000498 @@ -22966,17 +43690,25 @@ is_a: CL:0000099 ! interneuron id: CL:0000499 name: stromal cell namespace: cell +def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:D017154] def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830] xref: BTO:0002064 xref: FMA:83624 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal stem cell +[Term] +id: CL:0000500 +name: follicular epithelial cell +def: "An epithelial somatic cell associated with a maturing oocyte." [] +is_a: CL:0000066 ! epithelial cell +is_a: CL:0002371 ! somatic cell + [Term] id: CL:0000501 name: granulosa cell namespace: cell +def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:D006107] def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200] synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 @@ -22990,6 +43722,7 @@ id: CL:0000502 name: type D enteroendocrine cell namespace: cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175] +def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell @@ -22998,18 +43731,52 @@ is_a: CL:0000172 ! somatostatin secreting cell [Term] id: CL:0000503 name: theca cell -namespace: cell -def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400] +def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:D013799] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary +[Term] +id: CL:0000506 +name: enkephalin secreting cell +namespace: cell +def: "An endorphine cell that secretes enkephalin." [GO:tfm] +is_a: CL:0000507 ! endorphin secreting cell + +[Term] +id: CL:0000507 +name: endorphin secreting cell +namespace: cell +def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell + +[Term] +id: CL:0000508 +name: type G enteroendocrine cell +namespace: cell +def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300] +def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863] +synonym: "G cell" EXACT [] +xref: BTO:0004108 +xref: FMA:67609 +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0000506 ! enkephalin secreting cell +is_a: CL:0000509 ! gastrin secreting cell +is_a: CL:0002180 ! mucous cell of stomach +relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum + +[Term] +id: CL:0000509 +name: gastrin secreting cell +namespace: cell +def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell + [Term] id: CL:0000510 name: paneth cell -namespace: cell -def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700] +def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:D019879] xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell @@ -23029,6 +43796,7 @@ name: cardiac muscle myoblast namespace: cell alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470] +def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] synonym: "cardiac muscle progenitor cell" EXACT [] synonym: "cardiomyocyte progenitor cell" EXACT [] xref: FMA:84797 @@ -23044,6 +43812,7 @@ id: CL:0000514 name: smooth muscle myoblast namespace: cell def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390] +def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 @@ -23069,16 +43838,14 @@ relationship: develops_into CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000517 name: macrophage derived foam cell -namespace: cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] -is_a: CARO:0000000 ! anatomical entity +synonym: "lipophage" EXACT [] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) -namespace: cell def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte is_a: CL:0000548 ! animal cell @@ -23086,7 +43853,6 @@ is_a: CL:0000548 ! animal cell [Term] id: CL:0000521 name: fungal cell -namespace: cell is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000003 ! native cell intersection_of: only_in_taxon NCBITaxon:4751 ! Fungi @@ -23104,11 +43870,14 @@ synonym: "syntrophoblast" EXACT [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:2000060 ! placental villous trophoblast +intersection_of: CL:0000351 ! trophoblast cell +intersection_of: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000526 name: afferent neuron namespace: cell +def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650] synonym: "input neuron" EXACT [] xref: FMA:87653 @@ -23119,6 +43888,7 @@ id: CL:0000527 name: efferent neuron namespace: cell def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655] +def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron @@ -23131,13 +43901,11 @@ is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron -namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000531 name: primary sensory neuron -namespace: cell is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron intersection_of: CL:0000101 ! sensory neuron @@ -23147,6 +43915,7 @@ intersection_of: CL:0000530 ! primary neuron id: CL:0000540 name: neuron namespace: cell +def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:A08.663, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. synonym: "nerve cell" EXACT [] @@ -23156,12 +43925,12 @@ xref: FBbt:00005106 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 -is_a: BFO:0000040 ! material entity is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) +property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl.owl [Term] id: CL:0000541 @@ -23185,6 +43954,7 @@ comment: Editors note: consider adding taxon constraint to vertebrata (PMID:1802 xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 +xref: MESH:D008214 xref: VHOG:0001535 is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000738 ! leukocyte @@ -23201,7 +43971,6 @@ relationship: has_part GO:0000792 ! heterochromatin [Term] id: CL:0000545 name: T-helper 1 cell -namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. synonym: "helper T cell type 1" EXACT [] @@ -23220,7 +43989,6 @@ is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell [Term] id: CL:0000546 name: T-helper 2 cell -namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. synonym: "helper T cell type 2" EXACT [] @@ -23233,6 +44001,7 @@ synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 +xref: MESH:D018418 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell is_a: CL:0001051 ! CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell @@ -23369,6 +44138,7 @@ synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 +xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell @@ -23402,6 +44172,12 @@ relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 (mouse) +[Term] +id: CL:0000555 +name: neuronal brush cell +namespace: cell +is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) + [Term] id: CL:0000556 name: megakaryocyte @@ -23464,7 +44240,7 @@ namespace: cell def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] xref: BTO:0001173 xref: CALOHA:TS-0864 -is_a: BFO:0000040 ! material entity +xref: MESH:D012156 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: capable_of GO:0071971 ! extracellular exosome assembly @@ -23518,11 +44294,15 @@ id: CL:0000561 name: amacrine cell namespace: cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A08.663.358.050, WikipediaVersioned:Amacrine_cell&oldid=1023572246] +def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246] synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FMA:67766 is_a: CL:0000099 ! interneuron is_a: CL:0009004 ! retinal cell +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: part_of UBERON:0000966 ! retina +relationship: RO:0002120 CL:0000740 ! synapsed to retinal ganglion cell [Term] id: CL:0000562 @@ -23559,7 +44339,6 @@ relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute ly [Term] id: CL:0000567 name: polymodal nocireceptor -namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] @@ -23577,7 +44356,6 @@ id: CL:0000569 name: cardiac mesenchymal cell namespace: cell def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0008019 ! mesenchymal cell intersection_of: CL:0008019 ! mesenchymal cell intersection_of: develops_into CL:0002494 ! cardiocyte @@ -23598,12 +44376,15 @@ xref: SCTID:176770005 is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell +relationship: capable_of GO:0014046 ! dopamine secretion relationship: develops_from CL:0000333 ! migratory neural crest cell +relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland [Term] id: CL:0000573 name: retinal cone cell namespace: cell +def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A08.663.650.650.670.100] xref: BTO:0001036 xref: CALOHA:TS-0866 @@ -23624,13 +44405,16 @@ xref: FMA:70551 is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell +intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000964 ! cornea -relationship: part_of UBERON:0000964 ! cornea +intersection_of: part_of UBERON:0001772 ! corneal epithelium +relationship: part_of UBERON:0001772 ! corneal epithelium [Term] id: CL:0000576 name: monocyte namespace: cell +def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000] def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:A11.118.637.555.652] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 @@ -23652,8 +44436,7 @@ relationship: develops_from CL:0000559 ! promonocyte [Term] id: CL:0000581 name: peritoneal macrophage -namespace: cell -def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:A11.329.372.630, PMID:15771589, PMID:19201820] +def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:D017737, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 @@ -23662,8 +44445,7 @@ is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage [Term] id: CL:0000583 name: alveolar macrophage -namespace: cell -def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A11.329.372.600] +def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:D016676] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] @@ -23676,10 +44458,12 @@ is_a: CL:1001603 ! lung macrophage [Term] id: CL:0000584 name: enterocyte -namespace: cell def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] +synonym: "differentiated enterocyte" NARROW [https://orcid.org/0000-0001-9610-7627, PMID:33290721] +synonym: "mature enterocyte" NARROW [https://orcid.org/0000-0001-9610-7627, PMID:33290721] xref: BTO:0000398 xref: FMA:62122 +xref: MESH:D020895 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell @@ -23688,18 +44472,19 @@ is_a: CL:0002563 ! intestinal epithelial cell id: CL:0000586 name: germ cell namespace: cell +def: "The reproductive cell in multicellular organisms." [MESH:D005854] def: "The reproductive cell in multicellular organisms." [MESH:A05.360.490] xref: BTO:0000535 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell relationship: capable_of GO:0048609 ! multicellular organismal reproductive process +relationship: capable_of_part_of GO:0009566 ! fertilization [Term] id: CL:0000589 name: cochlear inner hair cell -namespace: cell -def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A08.663.650.250.250] +def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:D006199] synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 @@ -23708,7 +44493,6 @@ is_a: CL:4023120 ! cochlea auditory hair cell [Term] id: CL:0000593 name: androgen secreting cell -namespace: cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell @@ -23718,8 +44502,7 @@ relationship: capable_of GO:0035935 ! androgen secretion [Term] id: CL:0000594 name: skeletal muscle satellite cell -namespace: cell -def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [GOC:tfm, MESH:A11.635.500.700, PMID:21849021, PMID:23303905] +def: "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers." [GOC:tfm, MESH:D032496, PMID:21849021, PMID:23303905] comment: Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000680 ! muscle precursor cell @@ -23740,8 +44523,7 @@ relationship: develops_from CL:0002422 ! enucleated reticulocyte [Term] id: CL:0000598 name: pyramidal neuron -namespace: cell -def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:A08.186.211.577.405.700] +def: "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." [GOC:tfm, MESH:D017966] subset: BDS_subset synonym: "projection neuron" EXACT [] synonym: "pyramidal cell" EXACT [] @@ -23755,8 +44537,7 @@ is_a: CL:0000104 ! multipolar neuron [Term] id: CL:0000601 name: cochlear outer hair cell -namespace: cell -def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A08.663.650.250.315] +def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:D018072] xref: BTO:0003666 xref: FMA:62366 is_a: CL:4023120 ! cochlea auditory hair cell @@ -23764,14 +44545,14 @@ is_a: CL:4023120 ! cochlea auditory hair cell [Term] id: CL:0000602 name: pressoreceptor cell -namespace: cell -def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A08.800.050.800.900.700] +def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:D011311] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000604 name: retinal rod cell namespace: cell +def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A08.663.650.650.670.650] xref: BTO:0001024 xref: CALOHA:TS-0870 @@ -23782,12 +44563,26 @@ relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000609 name: vestibular hair cell -namespace: cell -def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A08.663.650.250.380] +def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:D018069] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell +[Term] +id: CL:0000613 +name: basophil progenitor cell +namespace: cell +def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421] +comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). +synonym: "BaP" EXACT [] +synonym: "basophilic stem cell" RELATED [] +synonym: "CFU-Bas" RELATED [] +synonym: "colony forming unit basophil" RELATED [] +is_a: CL:0000763 ! myeloid cell +is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell +relationship: capable_of GO:0030221 ! basophil differentiation +relationship: develops_from CL:0002028 ! basophil mast progenitor cell + [Term] id: CL:0000617 name: GABAergic neuron @@ -23795,9 +44590,13 @@ namespace: cell def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 +xref: MESH:D059330 xref: WBbt:0005190 is_a: CL:0000161 ! acid secreting cell is_a: CL:0000540 ! neuron +intersection_of: CL:0000540 ! neuron +intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission +relationship: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0000622 @@ -23807,8 +44606,10 @@ def: "A secretory cell that is grouped together with other cells of the same typ synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 +xref: MESH:D061354 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell +relationship: part_of UBERON:0009842 ! glandular acinus [Term] id: CL:0000623 @@ -23823,8 +44624,11 @@ xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 +xref: MESH:D007694 xref: VHOG:0001697 is_a: CL:0001067 ! group 1 innate lymphoid cell +relationship: capable_of GO:0002228 ! natural killer cell mediated immunity +relationship: capable_of GO:0050776 ! regulation of immune response relationship: develops_from CL:0000825 ! pro-NK cell [Term] @@ -23836,6 +44640,7 @@ synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell +disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell [Term] id: CL:0000625 @@ -23847,6 +44652,24 @@ synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell +[Term] +id: CL:0000626 +name: olfactory granule cell +namespace: cell +def: "Granule cell that is part of the olfactory bulb." [GOC:mah] +is_a: CL:0000120 ! granule cell +is_a: CL:0012001 ! neuron of the forebrain +intersection_of: CL:0000120 ! granule cell +intersection_of: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb +relationship: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb + +[Term] +id: CL:0000627 +name: transporting cell +namespace: cell +def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] +is_a: CL:0000003 ! native cell + [Term] id: CL:0000630 name: supporting cell @@ -23859,7 +44682,6 @@ is_a: CL:0000003 ! native cell [Term] id: CL:0000632 name: hepatic stellate cell -namespace: cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. synonym: "fat-storing cell" RELATED [] @@ -23872,13 +44694,11 @@ xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 is_a: CL:0000057 ! fibroblast -is_a: CL:0000152 ! exocrine cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000633 name: Hensen cell -namespace: cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] @@ -23889,7 +44709,6 @@ is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell -namespace: cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" RELATED [] @@ -23900,7 +44719,6 @@ is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell -namespace: cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] @@ -23917,6 +44735,7 @@ synonym: "Müller cell" EXACT [] xref: BTO:0003064 is_a: CL:0000681 ! radial glial cell is_a: CL:0009004 ! retinal cell +relationship: part_of UBERON:0000966 ! retina [Term] id: CL:0000637 @@ -23929,11 +44748,26 @@ is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002319 ! neural cell is_a: CL:2000004 ! pituitary gland cell +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0002196 ! adenohypophysis +relationship: part_of UBERON:0002196 ! adenohypophysis + +[Term] +id: CL:0000638 +name: acidophil cell of pars distalis of adenohypophysis +namespace: cell +def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] +synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] +synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] +synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] +synonym: "pituitary alpha cell" EXACT [] +xref: FMA:83093 +is_a: CL:0000637 ! chromophil cell of anterior pituitary gland +relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis -namespace: cell def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] @@ -23952,7 +44786,6 @@ is_a: CL:0000630 ! supporting cell [Term] id: CL:0000644 name: Bergmann glial cell -namespace: cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] @@ -23962,11 +44795,11 @@ is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte -namespace: cell -def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651] +def: "A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651, PMID:31915267] xref: BTO:0003793 xref: FMA:83503 -is_a: CL:0000127 ! astrocyte +is_a: CL:0012000 ! astrocyte of the forebrain +is_a: CL:2000004 ! pituitary gland cell [Term] id: CL:0000646 @@ -23980,7 +44813,6 @@ is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000648 name: kidney granular cell -namespace: cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727] synonym: "JG cell" EXACT [] @@ -24000,25 +44832,24 @@ def: "A cell with delicate radiating processes known as desmosomes that form int synonym: "prickle cell of epidermis" EXACT [] xref: FMA:69059 is_a: CL:0000312 ! keratinocyte +relationship: part_of UBERON:0002026 ! stratum spinosum of epidermis [Term] id: CL:0000650 name: mesangial cell -namespace: cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells] comment: Do all of these cells really develop from some mesenchymal stem cell? synonym: "kidney mesangial cell" EXACT [] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 -is_a: CARO:0000000 ! anatomical entity +xref: MESH:D050527 is_a: CL:0000669 ! pericyte cell relationship: develops_from CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000651 name: mucous neck cell -namespace: cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] synonym: "neck cell" BROAD [] is_a: CL:0000150 ! glandular epithelial cell @@ -24034,20 +44865,24 @@ xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002319 ! neural cell +relationship: capable_of GO:0030187 ! melatonin biosynthetic process +relationship: part_of UBERON:0001905 ! pineal body [Term] id: CL:0000653 -name: glomerular visceral epithelial cell -namespace: cell -def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:tfm] -comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. +name: podocyte +def: "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes." [GOC:tfm, https://doi.org/10.1101/2021.10.10.463829] synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967] synonym: "glomerular podocyte" EXACT [FMA:70967] -synonym: "podocyte" EXACT [] +synonym: "glomerular visceral epithelial cell" EXACT [] +synonym: "kidney podocyte" EXACT [] +synonym: "renal podocyte" EXACT [] xref: BTO:0002295 xref: FMA:70967 is_a: CL:0002522 ! renal filtration cell is_a: CL:1000450 ! epithelial cell of glomerular capsule +property_value: dc-contributor http://orcid.org/0000-0002-1773-2692 xsd:string +property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/1460 xsd:string [Term] id: CL:0000656 @@ -24058,6 +44893,11 @@ xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte +intersection_of: CL:0000017 ! spermatocyte +intersection_of: bearer_of PATO:0001394 ! diploid +intersection_of: capable_of GO:0007140 ! male meiotic nuclear division +relationship: bearer_of PATO:0001394 ! diploid +relationship: capable_of GO:0007140 ! male meiotic nuclear division [Term] id: CL:0000657 @@ -24070,8 +44910,20 @@ xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte is_a: CL:0000413 ! haploid cell +intersection_of: CL:0000017 ! spermatocyte +intersection_of: bearer_of PATO:0001375 ! haploid +intersection_of: capable_of GO:0007142 ! male meiosis II +relationship: capable_of GO:0007142 ! male meiosis II relationship: develops_from CL:0000656 ! primary spermatocyte +[Term] +id: CL:0000666 +name: fenestrated cell +namespace: cell +synonym: "window cell" EXACT [] +is_a: CL:0000066 ! epithelial cell +is_a: CL:0002371 ! somatic cell + [Term] id: CL:0000667 name: collagen secreting cell @@ -24081,6 +44933,7 @@ is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000669 +name: pericyte name: pericyte cell namespace: cell alt_id: CL:0000184 @@ -24091,6 +44944,7 @@ synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [PMID:17986482] synonym: "cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] +synonym: "pericyte cell" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 @@ -24125,7 +44979,6 @@ is_a: CL:0000300 ! gamete [Term] id: CL:0000677 name: gut absorptive cell -namespace: cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] is_a: CL:0000212 ! absorptive cell @@ -24145,7 +44998,6 @@ id: CL:0000680 name: muscle precursor cell namespace: cell def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0011115 ! precursor cell @@ -24166,7 +45018,6 @@ relationship: develops_from CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000695 name: Cajal-Retzius cell -namespace: cell def: "A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912] comment: While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity. {xref="PMID:10600995"} synonym: "CR cells" EXACT [WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753] @@ -24189,15 +45040,38 @@ is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000700 name: dopaminergic neuron -namespace: cell def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FMA:84787 +xref: MESH:D059290 xref: WBbt:0006746 is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron +[Term] +id: CL:0000703 +name: sustentacular cell +namespace: cell +def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] +xref: BTO:0002315 +is_a: CL:0000630 ! supporting cell + +[Term] +id: CL:0000706 +name: choroid plexus epithelial cell +namespace: cell +alt_id: CL:1000430 +def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] +synonym: "epithelial cell of choroid plexus" EXACT [] +xref: FMA:70549 +is_a: CL:0000065 ! ependymal cell +is_a: CL:0000627 ! transporting cell +is_a: CL:0002319 ! neural cell +intersection_of: CL:0000065 ! ependymal cell +intersection_of: part_of UBERON:0001886 ! choroid plexus +relationship: part_of UBERON:0001886 ! choroid plexus + [Term] id: CL:0000710 name: neurecto-epithelial cell @@ -24213,6 +45087,15 @@ intersection_of: CL:0002077 ! ecto-epithelial cell intersection_of: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000133 ! neurectodermal cell +[Term] +id: CL:0000712 +name: stratum granulosum cell +namespace: cell +is_a: CL:0000362 ! epidermal cell +intersection_of: CL:0000362 ! epidermal cell +intersection_of: part_of UBERON:0002069 ! stratum granulosum of epidermis +relationship: part_of UBERON:0002069 ! stratum granulosum of epidermis + [Term] id: CL:0000723 name: somatic stem cell @@ -24220,12 +45103,27 @@ namespace: cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: FMA:63368 +xref: MESH:D053687 is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000034 ! stem cell intersection_of: capable_of GO:0048103 ! somatic stem cell division relationship: capable_of GO:0048103 ! somatic stem cell division +[Term] +id: CL:0000731 +name: urothelial cell +namespace: cell +def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma] +synonym: "bladder transitional cell" NARROW [] +synonym: "transitional epithelial cell of urinary bladder" NARROW [] +synonym: "urinary tract transitional epithelial cell" NARROW [] +xref: FMA:84127 +is_a: CL:0000244 {is_inferred="true"} ! transitional epithelial cell +intersection_of: CL:0000244 ! transitional epithelial cell +intersection_of: part_of UBERON:0000365 ! urothelium +relationship: part_of UBERON:0000365 ! urothelium + [Term] id: CL:0000737 name: striated muscle cell @@ -24253,7 +45151,7 @@ synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 -is_a: CARO:0000000 ! anatomical entity +xref: MESH:D007962 is_a: CL:0000219 ! motile cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell is_a: CL:0002242 ! nucleate cell @@ -24262,7 +45160,7 @@ intersection_of: bearer_of PATO:0002505 ! nucleated intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration relationship: capable_of GO:0001667 ! ameboidal-type cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002405 ! immune system [Term] @@ -24275,6 +45173,7 @@ synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: BTO:0001800 xref: FMA:67765 +xref: MESH:D012165 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: RO:0002100 UBERON:0000966 ! has soma location retina @@ -24287,6 +45186,7 @@ synonym: "horizontal cell" EXACT [] xref: BTO:0004120 is_a: CL:0000099 ! interneuron is_a: CL:0009004 ! retinal cell +relationship: part_of UBERON:0003902 ! retinal neural layer [Term] id: CL:0000746 @@ -24303,6 +45203,7 @@ synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 +xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell @@ -24324,13 +45225,15 @@ is_a: CL:0008028 ! visual system neuron is_a: CL:0008030 ! excitatory neuron is_a: CL:0009004 ! retinal cell intersection_of: CL:0000103 ! bipolar neuron +intersection_of: CL:0000103 ! bipolar neuron intersection_of: part_of UBERON:0000966 ! retina +intersection_of: RO:0002100 UBERON:0000966 ! has soma location retina relationship: part_of UBERON:0000966 ! retina +relationship: RO:0002100 UBERON:0000966 ! has soma location retina [Term] id: CL:0000751 name: rod bipolar cell -namespace: cell def: "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." [GOC:tfm, PMID:14689473] xref: FMA:67750 is_a: CL:0000748 ! retinal bipolar neuron @@ -24338,7 +45241,6 @@ is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000752 name: cone retinal bipolar cell -namespace: cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron @@ -24350,6 +45252,10 @@ def: "A nucleated blood cell involved in coagulation, typically seen in birds an comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell +intersection_of: CL:0000763 ! myeloid cell +intersection_of: bearer_of PATO:0001407 ! mononucleate +intersection_of: capable_of GO:0007596 ! blood coagulation +relationship: capable_of GO:0007596 ! blood coagulation relationship: develops_from CL:0000828 ! thromboblast [Term] @@ -24359,7 +45265,7 @@ namespace: cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] xref: BTO:0001441 xref: CALOHA:TS-0647 -is_a: CARO:0000000 ! anatomical entity +xref: MESH:D022423 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor @@ -24387,6 +45293,7 @@ synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 +xref: MESH:D004900 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell @@ -24433,7 +45340,6 @@ intersection_of: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil -namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] @@ -24460,6 +45366,7 @@ synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 +xref: MESH:D004804 is_a: CL:0000094 {is_inferred="true"} ! granulocyte [Term] @@ -24482,6 +45389,7 @@ synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 +xref: MESH:D009504 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: RO:0002104 PR:000001479 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor II @@ -24492,7 +45400,6 @@ relationship: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin [Term] id: CL:0000778 name: mononuclear osteoclast -namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 {is_inferred="true"} ! osteoclast @@ -24503,7 +45410,6 @@ intersection_of: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast -namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] @@ -24535,7 +45441,6 @@ relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor c [Term] id: CL:0000783 name: multinucleated phagocyte -namespace: cell def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) @@ -24543,7 +45448,6 @@ is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) [Term] id: CL:0000784 name: plasmacytoid dendritic cell -namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] @@ -24568,7 +45472,16 @@ synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive +intersection_of: CL:0001201 ! B cell, CD19-positive +intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +intersection_of: capable_of GO:0042113 ! B cell activation +intersection_of: has_completed GO:0002335 ! mature B cell differentiation +disjoint_from: CL:0000816 ! immature B cell +disjoint_from: CL:0000817 ! precursor B cell +disjoint_from: CL:0000818 ! transitional stage B cell +relationship: capable_of GO:0042113 ! B cell activation relationship: develops_from CL:0000818 ! transitional stage B cell +relationship: has_completed GO:0002335 ! mature B cell differentiation [Term] id: CL:0000786 @@ -24584,8 +45497,13 @@ synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 +xref: MESH:D010950 is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell relationship: develops_from CL:0000980 ! plasmablast +relationship: has_part CL:0017508 ! cartwheel heterochromatin +relationship: has_part GO:0005794 ! Golgi apparatus +relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex +relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex [Term] id: CL:0000787 @@ -24597,6 +45515,8 @@ synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell +relationship: has_completed GO:0002344 ! B cell affinity maturation +relationship: RO:0002104 GO:0042613 ! has plasma membrane part MHC class II protein complex [Term] id: CL:0000788 @@ -24608,6 +45528,9 @@ synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell +relationship: has_not_completed GO:0002344 ! B cell affinity maturation +relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex +relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex [Term] id: CL:0000789 @@ -24618,6 +45541,9 @@ synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex +relationship: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex [Term] id: CL:0000790 @@ -24629,6 +45555,8 @@ synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002420 ! immature T cell +intersection_of: CL:0000789 ! alpha-beta T cell +intersection_of: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000791 @@ -24640,12 +45568,14 @@ synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002419 ! mature T cell +intersection_of: CL:0000789 ! alpha-beta T cell +intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000790 ! immature alpha-beta T cell +relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell -namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] @@ -24662,7 +45592,6 @@ is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell -namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] @@ -24676,7 +45605,6 @@ relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell -namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] @@ -24698,7 +45626,6 @@ relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T ce [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell -namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] @@ -24719,7 +45646,6 @@ is_a: CL:0000815 ! regulatory T cell [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell -namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] @@ -24731,7 +45657,6 @@ is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell -namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] @@ -24744,7 +45669,6 @@ is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000798 name: gamma-delta T cell -namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] @@ -24757,7 +45681,6 @@ is_a: CL:0000084 {is_inferred="true"} ! T cell [Term] id: CL:0000799 name: immature gamma-delta T cell -namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] @@ -24770,7 +45693,6 @@ relationship: develops_from CL:0000807 ! DN3 thymocyte [Term] id: CL:0000800 name: mature gamma-delta T cell -namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] @@ -24782,7 +45704,6 @@ relationship: develops_from CL:0000799 ! immature gamma-delta T cell [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell -namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] @@ -24795,7 +45716,6 @@ is_a: CL:0002496 ! intraepithelial lymphocyte [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell -namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] @@ -24807,7 +45727,6 @@ is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell -namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] @@ -24829,6 +45748,7 @@ synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte relationship: develops_from CL:0000808 ! DN4 thymocyte +relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex [Term] id: CL:0000806 @@ -24866,6 +45786,7 @@ synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte relationship: develops_from CL:0000806 ! DN2 thymocyte +relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex [Term] id: CL:0000808 @@ -24883,6 +45804,7 @@ synonym: "early cortical thymocyte" BROAD [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte relationship: develops_from CL:0000807 ! DN3 thymocyte +relationship: RO:0002104 GO:0043384 ! has plasma membrane part pre-T cell receptor complex [Term] id: CL:0000809 @@ -24928,7 +45850,6 @@ relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000813 name: memory T cell -namespace: cell def: "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] @@ -24939,7 +45860,6 @@ is_a: CL:0002419 {is_inferred="true"} ! mature T cell [Term] id: CL:0000814 name: mature NK T cell -namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] @@ -24955,7 +45875,6 @@ relationship: develops_from CL:0002042 ! immature NK T cell stage IV [Term] id: CL:0000815 name: regulatory T cell -namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] @@ -24968,6 +45887,7 @@ synonym: "suppressor T-lymphocyte" BROAD [] synonym: "Treg" EXACT [] xref: BTO:0004520 xref: FMA:84070 +xref: MESH:D050378 is_a: CL:0002419 {is_inferred="true"} ! mature T cell [Term] @@ -24982,6 +45902,9 @@ synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [ISBN:781735149] is_a: CL:0001201 ! B cell, CD19-positive relationship: develops_from CL:0000954 ! small pre-B-II cell +relationship: has_not_completed GO:0045190 ! isotype switching +relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex +relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex [Term] id: CL:0000817 @@ -24992,6 +45915,8 @@ synonym: "pre-B cell" RELATED [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive +disjoint_from: CL:0000826 ! pro-B cell +relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000818 @@ -25008,6 +45933,8 @@ synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0001201 {is_inferred="true"} ! B cell, CD19-positive relationship: develops_from CL:0000816 ! immature B cell +relationship: has_not_completed GO:0002335 ! mature B cell differentiation +relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex [Term] id: CL:0000819 @@ -25025,6 +45952,8 @@ synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell +relationship: capable_of GO:0045087 ! innate immune response +relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000820 @@ -25086,12 +46015,14 @@ synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000623 ! natural killer cell is_a: CL:0001082 ! immature innate lymphoid cell +intersection_of: CL:0000623 ! natural killer cell +intersection_of: bearer_of PATO:0001501 ! immature +disjoint_from: CL:0000937 ! pre-natural killer cell relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell -namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] @@ -25131,6 +46062,7 @@ synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell relationship: develops_from CL:0000051 ! common lymphoid progenitor +relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: CL:0000827 @@ -25157,8 +46089,23 @@ comment: Note that this is a non-mammalian cell type. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell +intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell +intersection_of: bearer_of PATO:0001407 ! mononucleate +intersection_of: capable_of GO:0002574 ! thrombocyte differentiation +relationship: capable_of GO:0002574 ! thrombocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell +[Term] +id: CL:0000829 +name: basophilic myeloblast +namespace: cell +def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] +is_a: CL:0000835 {is_inferred="true"} ! myeloblast +intersection_of: CL:0000835 ! myeloblast +intersection_of: capable_of GO:0030221 ! basophil differentiation +relationship: capable_of GO:0030221 ! basophil differentiation +relationship: develops_from CL:0000613 ! basophil progenitor cell + [Term] id: CL:0000831 name: mast cell progenitor @@ -25171,12 +46118,12 @@ synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell +relationship: capable_of GO:0060374 ! mast cell differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell [Term] id: CL:0000834 name: neutrophil progenitor cell -namespace: cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell @@ -25216,7 +46163,6 @@ synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001402 ! multipotent @@ -25312,11 +46258,12 @@ synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell +relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex +relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex [Term] id: CL:0000844 name: germinal center B cell -namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] @@ -25347,33 +46294,60 @@ synonym: "MZ B-cell" BROAD [] synonym: "MZ B-lymphocyte" BROAD [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:2000074 ! splenocyte +relationship: capable_of GO:0042742 ! defense response to bacterium +relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex +relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000846 name: vestibular dark cell -namespace: cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell +[Term] +id: CL:0000847 +name: ciliated olfactory receptor neuron +namespace: cell +def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] +synonym: "ciliated olfactory sensory neuron" EXACT [] +synonym: "ciliated sensory neuron" EXACT [] +is_a: CL:0000064 ! ciliated cell +is_a: CL:0000207 ! olfactory receptor cell +intersection_of: CL:0000207 ! olfactory receptor cell +intersection_of: has_part GO:0005929 ! cilium + [Term] id: CL:0000850 name: serotonergic neuron -namespace: cell alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] -xref: FBbt:00005133 +xref: MESH:D059326 xref: WBbt:0006837 is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000540 ! neuron +[Term] +id: CL:0000853 +name: olfactory epithelial supporting cell +namespace: cell +def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] +synonym: "olfactory epithelial support cell" EXACT [] +synonym: "olfactory sustentacular cell" EXACT [] +synonym: "supporting cell of olfactory epithelium" EXACT [] +synonym: "sustentaculocyte of olfactory epithelium" EXACT [] +xref: FMA:62302 +is_a: CL:0000630 ! supporting cell +is_a: CL:0002169 ! basal cell of olfactory epithelium +intersection_of: CL:0000630 ! supporting cell +intersection_of: part_of UBERON:0001997 ! olfactory epithelium + [Term] id: CL:0000855 name: sensory hair cell -namespace: cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] synonym: "hair cell" BROAD [] xref: BTO:0004744 @@ -25382,14 +46356,12 @@ is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000857 name: slow muscle myoblast -namespace: cell def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000858 name: fast muscle myoblast -namespace: cell def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast @@ -25410,14 +46382,12 @@ relationship: part_of UBERON:0000479 ! tissue [Term] id: CL:0000867 name: secondary lymphoid organ macrophage -namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000871 name: splenic macrophage -namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 @@ -25427,7 +46397,6 @@ is_a: CL:2000074 ! splenocyte [Term] id: CL:0000872 name: splenic marginal zone macrophage -namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage @@ -25451,14 +46420,15 @@ namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage +relationship: part_of UBERON:0001981 ! blood vessel [Term] id: CL:0000891 name: foam cell -namespace: cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] xref: BTO:0003872 xref: FMA:83586 +xref: MESH:D005487 is_a: CL:0000003 ! native cell [Term] @@ -25474,8 +46444,13 @@ synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 +xref: MESH:D060168 xref: XAO:0003159 is_a: CL:0002420 {is_inferred="true"} ! immature T cell +intersection_of: CL:0000084 ! T cell +intersection_of: has_not_completed GO:0045058 ! T cell selection +intersection_of: part_of UBERON:0002370 ! thymus +relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 @@ -25491,6 +46466,7 @@ synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell relationship: develops_from CL:0002425 ! early T lineage precursor +relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 @@ -25522,7 +46498,6 @@ relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alph [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell -namespace: cell def: "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell." [GOC:add, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] @@ -25535,7 +46510,6 @@ property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0 [Term] id: CL:0000898 name: naive T cell -namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] @@ -25545,7 +46519,6 @@ is_a: CL:0002419 {is_inferred="true"} ! mature T cell [Term] id: CL:0000899 name: T-helper 17 cell -namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. synonym: "helper T cell type 17" EXACT [] @@ -25558,6 +46531,7 @@ synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] +xref: MESH:D058504 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell [Term] @@ -25578,7 +46552,6 @@ relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell -namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] @@ -25594,7 +46567,6 @@ is_a: CL:0001204 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell, [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell -namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] @@ -25610,7 +46582,6 @@ is_a: CL:0001204 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell, [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell -namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] @@ -25621,7 +46592,6 @@ relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alph [Term] id: CL:0000907 name: central memory CD8-positive, alpha-beta T cell -namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] @@ -25637,7 +46607,6 @@ is_a: CL:0001203 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell, [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell -namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] @@ -25648,7 +46617,6 @@ relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T ce [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell -namespace: cell def: "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell." [GOC:add, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] @@ -25661,7 +46629,6 @@ property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0 [Term] id: CL:0000910 name: cytotoxic T cell -namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] @@ -25674,7 +46641,6 @@ is_a: CL:0000911 {is_inferred="true"} ! effector T cell [Term] id: CL:0000911 name: effector T cell -namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] @@ -25684,19 +46650,18 @@ is_a: CL:0002419 {is_inferred="true"} ! mature T cell [Term] id: CL:0000912 name: helper T cell -namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 +xref: MESH:D006377 is_a: CL:0000911 {is_inferred="true"} ! effector T cell [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell -namespace: cell def: "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] @@ -25712,7 +46677,6 @@ is_a: CL:0001203 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell, [Term] id: CL:0000914 name: immature NK T cell -namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] @@ -25724,7 +46688,6 @@ relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte [Term] id: CL:0000916 name: dendritic epidermal T cell -namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] @@ -25737,7 +46700,6 @@ relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell prec [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell -namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] @@ -25755,7 +46717,6 @@ relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T ce [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell -namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] @@ -25786,6 +46747,9 @@ name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149] is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage +intersection_of: CL:0000945 ! lymphocyte of B lineage +intersection_of: produces GO:0042571 ! immunoglobulin complex, circulating +relationship: produces GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000954 @@ -25795,6 +46759,9 @@ def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-posit comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell +relationship: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex +relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex +relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination [Term] id: CL:0000955 @@ -25807,6 +46774,7 @@ synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 {is_inferred="true"} ! precursor B cell +relationship: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination [Term] id: CL:0000958 @@ -25819,6 +46787,7 @@ synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell +relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000959 @@ -25832,11 +46801,11 @@ synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell relationship: develops_from CL:0000958 ! T1 B cell +relationship: RO:0002104 GO:0071738 ! has plasma membrane part IgD immunoglobulin complex [Term] id: CL:0000960 name: T3 B cell -namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] synonym: "An1 B cell" EXACT [PMID:17174121] synonym: "T3 B lymphocyte" EXACT [] @@ -25846,10 +46815,28 @@ synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell relationship: develops_from CL:0000959 ! T2 B cell +[Term] +id: CL:0000971 +name: IgM memory B cell +namespace: cell +def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676] +comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. +synonym: "IgM memory B lymphocyte" EXACT [] +synonym: "IgM memory B-cell" EXACT [] +synonym: "IgM memory B-lymphocyte" EXACT [] +synonym: "memory IgM B cell" EXACT [] +synonym: "memory IgM B lymphocyte" EXACT [] +synonym: "memory IgM B-cell" EXACT [] +synonym: "memory IgM B-lymphocyte" EXACT [] +is_a: CL:0001053 ! IgD-negative memory B cell +intersection_of: CL:0000787 ! memory B cell +intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex +intersection_of: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex +relationship: RO:0002104 GO:0071753 ! has plasma membrane part IgM immunoglobulin complex + [Term] id: CL:0000974 name: long lived plasma cell -namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell relationship: develops_from CL:0000975 ! short lived plasma cell @@ -25857,7 +46844,6 @@ relationship: develops_from CL:0000975 ! short lived plasma cell [Term] id: CL:0000975 name: short lived plasma cell -namespace: cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell @@ -25904,8 +46890,8 @@ synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell -intersection_of: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X -relationship: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X +intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X +relationship: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X [Term] id: CL:0000995 @@ -25920,7 +46906,6 @@ union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell -namespace: cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). synonym: "LSK stem cell" EXACT [] @@ -25960,7 +46945,6 @@ union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor -namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte @@ -25991,7 +46975,6 @@ relationship: RO:0002104 PR:000001898 ! has plasma membrane part neprilysin [Term] id: CL:0001022 name: CD115-positive monocyte -namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 {is_inferred="true"} ! monocyte @@ -26043,19 +47026,19 @@ synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive -intersection_of: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001898 ! neprilysin intersection_of: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 +intersection_of: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell -relationship: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001898 ! neprilysin relationship: RO:0002104 PR:000001408 ! has plasma membrane part ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 +relationship: RO:0015016 PR:000001865 ! has low plasma membrane amount interleukin-3 receptor class 2 alpha chain [Term] id: CL:0001027 @@ -26078,7 +47061,6 @@ relationship: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell -namespace: cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] @@ -26095,7 +47077,6 @@ relationship: RO:0002104 PR:000001836 ! has plasma membrane part CD7 molecule [Term] id: CL:0001029 name: common dendritic progenitor -namespace: cell def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). synonym: "CDP" EXACT [PMID:21219184] @@ -26104,7 +47085,6 @@ synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0000763 ! myeloid cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell -intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M @@ -26119,8 +47099,8 @@ intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 (mouse) intersection_of: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor +intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor -relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M @@ -26135,6 +47115,7 @@ relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 (mouse) relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3 relationship: RO:0002104 PR:000002062 ! has plasma membrane part macrophage colony-stimulating factor 1 receptor +relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor [Term] id: CL:0001031 @@ -26143,6 +47124,10 @@ namespace: cell def: "Granule cell that is part of the cerebellum." [GOC:mah] xref: BTO:0004278 is_a: CL:0000120 {is_inferred="true"} ! granule cell +is_a: CL:1001611 ! cerebellar neuron +intersection_of: CL:0000120 ! granule cell +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0001032 @@ -26152,6 +47137,8 @@ def: "Granule cell that is part of the cerebral cortex." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0010012 ! cerebral cortex neuron is_a: CL:0012001 ! neuron of the forebrain +intersection_of: CL:0000120 ! granule cell +intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex [Term] id: CL:0001033 @@ -26159,13 +47146,16 @@ name: hippocampal granule cell namespace: cell def: "Granule cell that is part of the hippocampus." [GOC:mah] is_a: CL:0001032 ! cortical granule cell +is_a: CL:0002608 ! hippocampal neuron +intersection_of: CL:0000120 ! granule cell +intersection_of: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn +relationship: RO:0002100 UBERON:0001954 ! has soma location Ammon's horn [Term] id: CL:0001035 name: bone cell namespace: cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] -is_a: BFO:0000004 ! independent continuant is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001474 ! bone element @@ -26176,7 +47166,6 @@ creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001040 name: non-terminally differentiated osteoblast -namespace: cl def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 xref: VSAO:0000117 @@ -26186,7 +47175,6 @@ is_a: CL:0001035 ! bone cell [Term] id: CL:0001051 name: CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell -namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte" EXACT [] @@ -26195,10 +47183,21 @@ synonym: "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte" synonym: "non-Th1/Th17 CD4+ T cell" BROAD [PMID:22343568] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell +[Term] +id: CL:0001053 +name: IgD-negative memory B cell +namespace: cell +def: "A memory B cell that lacks expression of surface IgD." [GOC:add, PMID:22343568] +comment: This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'. The majority of these cells are class-switched, though some are IgM-positive. +synonym: "IgD- memory B cell" EXACT [PMID:22343568] +is_a: CL:0000787 ! memory B cell +intersection_of: CL:0000787 ! memory B cell +intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex +relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex + [Term] id: CL:0001054 name: CD14-positive monocyte -namespace: cell def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. synonym: "monocyte" NARROW [PMID:22343568] @@ -26285,13 +47284,14 @@ name: innate lymphoid cell namespace: cell def: "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] is_a: CL:0000542 ! lymphocyte +relationship: capable_of GO:0001816 ! cytokine production +relationship: capable_of GO:0045087 ! innate immune response property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:20:48Z xsd:dateTime [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian -namespace: cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] @@ -26335,13 +47335,24 @@ name: group 1 innate lymphoid cell namespace: cell def: "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines." [GOC:add, GOC:dsd, PMID:23348417] is_a: CL:0001065 ! innate lymphoid cell +intersection_of: CL:0001065 ! innate lymphoid cell +intersection_of: capable_of GO:0032609 ! interferon-gamma production +relationship: capable_of GO:0032609 ! interferon-gamma production property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:42:44Z xsd:dateTime +[Term] +id: CL:0001068 +name: ILC1 +namespace: cell +def: "A group 1 innate lymphoid cell that is non-cytotoxic." [GOC:add, GOC:dsd, PMID:23292121, PMID:23348417] +is_a: CL:0001067 ! group 1 innate lymphoid cell +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-9990-8331 +property_value: http://purl.org/dc/elements/1.1/date 2017-01-30T20:54:12Z xsd:dateTime + [Term] id: CL:0001070 name: beige adipocyte -namespace: cell def: "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." [GOC:add, GOC:cvs, GOC:ymb, PMID:22796012, PMID:25851693] synonym: "beige brown adipocyte" EXACT [] synonym: "beige fat cell" EXACT [] @@ -26349,6 +47360,7 @@ synonym: "beige/brite adipocyte" EXACT [] synonym: "brite adipocyte" EXACT [] synonym: "brite cell" EXACT [] synonym: "brite fat cell" EXACT [] +xref: MESH:D000069797 is_a: CL:0000136 ! fat cell [Term] @@ -26357,6 +47369,9 @@ name: immature innate lymphoid cell def: "An innate lyphoid cell with an immature phenotype." [GOC:add] synonym: "immature ILC" EXACT [] is_a: CL:0001065 ! innate lymphoid cell +intersection_of: CL:0001065 ! innate lymphoid cell +intersection_of: bearer_of PATO:0001501 ! immature +relationship: bearer_of PATO:0001501 ! immature [Term] id: CL:0001200 @@ -26365,6 +47380,7 @@ namespace: cell def: "A lymphocyte of B lineage that is CD19-positive." [GOC:add] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). is_a: CL:0000945 ! lymphocyte of B lineage +relationship: in_taxon NCBITaxon:40674 ! Mammalia property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-9990-8331 xsd:string [Term] @@ -26384,7 +47400,6 @@ property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0 [Term] id: CL:0001203 name: CD8-positive, alpha-beta memory T cell, CD45RO-positive -namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] @@ -26395,7 +47410,6 @@ relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T ce [Term] id: CL:0001204 name: CD4-positive, alpha-beta memory T cell, CD45RO-positive -namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell, CD45RO-positive" EXACT [] @@ -26406,7 +47420,6 @@ relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T ce [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell -namespace: cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. synonym: "c- Kit-positive erythroid progenitor cell" EXACT [] @@ -26435,7 +47448,6 @@ creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor -namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell @@ -26452,7 +47464,6 @@ creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell -namespace: cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell @@ -26471,25 +47482,24 @@ creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell -namespace: cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell -intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor -relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex +intersection_of: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor +relationship: RO:0015016 GO:0033001 ! has low plasma membrane amount Fc-gamma receptor III complex created_by: tmeehan creation_date: 2010-01-13T03:43:12Z @@ -26514,112 +47524,106 @@ creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002012 name: Kit-low proerythroblast -namespace: cell def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast -intersection_of: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 -intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse) +intersection_of: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1 +intersection_of: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell -relationship: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 -relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: RO:0002104 PR:000002981 ! has plasma membrane part lymphocyte antigen 76 (mouse) +relationship: RO:0015015 PR:000001945 ! has high plasma membrane amount transferrin receptor protein 1 +relationship: RO:0015016 PR:000002065 ! has low plasma membrane amount mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast -namespace: cell def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast -intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: develops_from CL:0002012 ! Kit-low proerythroblast -relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast -namespace: cell def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast -intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast -relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts -namespace: cell def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast -intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) -intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) +intersection_of: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast -relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) -relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 +relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) +relationship: RO:0015016 PR:000001945 ! has low plasma membrane amount transferrin receptor protein 1 created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte -namespace: cell def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte -intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) +intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts -relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) +relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte -namespace: cell def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte -intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) +intersection_of: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte -relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 (mouse) +relationship: RO:0015015 PR:000002981 ! has high plasma membrane amount lymphocyte antigen 76 (mouse) created_by: tmeehan creation_date: 2010-04-26T11:51:27Z @@ -26632,6 +47636,8 @@ comment: There may be an intermediate cell type. These cells also CD13-positive, synonym: "BMCP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell +relationship: capable_of GO:0030221 ! basophil differentiation +relationship: capable_of GO:0060374 ! mast cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell created_by: tmeehan creation_date: 2010-04-27T12:46:33Z @@ -26641,7 +47647,6 @@ id: CL:0002031 name: hematopoietic lineage restricted progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001400 ! unipotent @@ -26657,7 +47662,6 @@ name: hematopoietic oligopotent progenitor cell namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). -is_a: CARO:0000000 ! anatomical entity is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001401 ! oligopotent @@ -26669,7 +47673,6 @@ creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell -namespace: cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. synonym: "ST stem cell" EXACT [] @@ -26688,27 +47691,25 @@ creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell -namespace: cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell -intersection_of: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 intersection_of: RO:0002104 PR:000001833 ! has plasma membrane part SLAM family member 1 -relationship: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein +intersection_of: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002001 ! receptor-type tyrosine-protein kinase FLT3 +relationship: RO:0015016 PR:000001843 ! has low plasma membrane amount Thy-1 membrane glycoprotein created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell -namespace: cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell @@ -26728,7 +47729,6 @@ creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell -namespace: cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] @@ -26748,7 +47748,6 @@ creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002038 name: T follicular helper cell -namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829] synonym: "follicular B helper T cell" RELATED [PMID:22043829] synonym: "follicular helper T cell" RELATED [PMID:22649468] @@ -26765,7 +47764,6 @@ creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I -namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell created_by: tmeehan @@ -26774,7 +47772,6 @@ creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II -namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] @@ -26786,7 +47783,6 @@ creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III -namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell @@ -26797,7 +47793,6 @@ creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV -namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell @@ -26827,9 +47822,12 @@ creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell +name: fraction A pre-pro B cell namespace: cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] +def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] comment: Markers associated with mouse cells. +synonym: "fraction A" BROAD [] synonym: "fraction A" EXACT [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 {is_inferred="true"} ! pro-B cell @@ -26839,7 +47837,6 @@ creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell -namespace: cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000826 {is_inferred="true"} ! pro-B cell @@ -26849,7 +47846,6 @@ creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002048 name: late pro-B cell -namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 {is_inferred="true"} ! precursor B cell @@ -26860,7 +47856,6 @@ creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002060 name: melanophage -namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage created_by: tmeehan @@ -26886,6 +47881,9 @@ synonym: "type I alveolar epithelial cells" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000322 ! pneumocyte +intersection_of: CL:0000322 ! pneumocyte +intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system +relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system created_by: tmeehan creation_date: 2010-06-23T04:37:54Z @@ -26913,6 +47911,9 @@ xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte is_a: CL:1000272 ! lung secretory cell +intersection_of: CL:0000322 ! pneumocyte +intersection_of: capable_of GO:0032940 ! secretion by cell +intersection_of: capable_of GO:0043129 ! surfactant homeostasis created_by: tmeehan creation_date: 2010-06-24T12:04:13Z @@ -26927,13 +47928,16 @@ xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001599 ! pancreas exocrine glandular cell +intersection_of: CL:0000622 ! acinar cell +intersection_of: part_of UBERON:0001263 ! pancreatic acinus +relationship: has_part GO:0042589 ! zymogen granule membrane +relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell -namespace: cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] @@ -26989,7 +47993,6 @@ creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte -namespace: cell def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte @@ -26999,7 +48002,6 @@ creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell -namespace: cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell @@ -27013,7 +48015,6 @@ name: endo-epithelial cell namespace: cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] xref: FMA:69075 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000223 ! endodermal cell @@ -27026,7 +48027,6 @@ name: ecto-epithelial cell namespace: cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell @@ -27042,7 +48042,6 @@ namespace: cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell @@ -27051,6 +48050,22 @@ relationship: develops_from CL:0000222 ! mesodermal cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z +[Term] +id: CL:0002079 +name: pancreatic ductal cell +namespace: cell +def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] +xref: FMA:63099 +is_a: CL:0000069 ! branched duct epithelial cell +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity +intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct +relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity +relationship: part_of UBERON:0001064 ! ventral pancreatic duct +created_by: tmeehan +creation_date: 2010-06-30T08:49:43Z + [Term] id: CL:0002080 name: pancreatic centro-acinar cell @@ -27060,9 +48075,26 @@ synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity +intersection_of: part_of UBERON:0001263 ! pancreatic acinus +relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity +relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-30T08:49:52Z +[Term] +id: CL:0002081 +name: type II cell of carotid body +namespace: cell +def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] +synonym: "sheath cell of carotid body" EXACT [] +xref: FMA:84187 +is_a: CL:0000703 ! sustentacular cell +is_a: CL:0002256 ! supporting cell of carotid body +created_by: tmeehan +creation_date: 2010-06-30T04:23:42Z + [Term] id: CL:0002082 name: type II cell of adrenal medulla @@ -27074,6 +48106,9 @@ synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell +intersection_of: CL:0000336 ! adrenal medulla chromaffin cell +intersection_of: capable_of GO:0048242 ! epinephrine secretion +intersection_of: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T09:41:42Z @@ -27086,13 +48121,15 @@ synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000459 ! noradrenergic cell +intersection_of: CL:0000336 ! adrenal medulla chromaffin cell +intersection_of: capable_of GO:0048243 ! norepinephrine secretion +intersection_of: part_of UBERON:0001236 ! adrenal medulla created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell -namespace: cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] @@ -27128,7 +48165,6 @@ creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal -namespace: cell def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] @@ -27136,16 +48172,19 @@ synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell +intersection_of: CL:0000710 ! neurecto-epithelial cell +intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction +relationship: capable_of GO:0043134 ! regulation of hindgut contraction created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002090 name: polar body -namespace: cell def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X] xref: EHDAA2:0004716 xref: FMA:85543 +xref: MESH:D059705 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell @@ -27160,7 +48199,7 @@ def: "A cell found in the bone marrow. This can include fibroblasts, macrophages comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 -is_a: CARO:0000000 ! anatomical entity +xref: MESH:D001854 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow @@ -27171,7 +48210,6 @@ creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002095 name: hilus cell of ovary -namespace: cell def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 @@ -27191,13 +48229,14 @@ xref: FMA:69545 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell is_a: CL:1001601 ! adrenal gland glandular cell +intersection_of: CL:0002078 ! meso-epithelial cell +intersection_of: part_of UBERON:0001235 ! adrenal cortex created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002128 name: Tc17 cell -namespace: cell def: "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg." [GOC:add, GOC:dsd, GOC:tfm, PMID:19201830, PMID:22343568] comment: This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). synonym: "CD8-positive Th17 cell" EXACT [] @@ -27224,6 +48263,38 @@ relationship: part_of UBERON:0000992 ! ovary created_by: tmeehan creation_date: 2010-08-23T12:10:31Z +[Term] +id: CL:0002134 +name: stromal cell of ovarian medulla +namespace: cell +def: "A stromal cell of the ovarian medulla." [GOC:tfm] +xref: FMA:256171 +is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0013192 ! ovarian medulla +relationship: part_of UBERON:0013192 ! ovarian medulla +created_by: tmeehan +creation_date: 2010-08-23T12:12:17Z + +[Term] +id: CL:0002138 +name: endothelial cell of lymphatic vessel +namespace: cell +alt_id: CL:1000421 +def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] +synonym: "LEC" EXACT [] +synonym: "lymphatic endothelial cell" EXACT [] +xref: BTO:0004167 +xref: FMA:68458 +is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree +intersection_of: CL:0002139 ! endothelial cell of vascular tree +intersection_of: develops_from CL:0005022 ! vascular lymphangioblast +intersection_of: part_of UBERON:0001473 ! lymphatic vessel +relationship: develops_from CL:0005022 ! vascular lymphangioblast +relationship: part_of UBERON:0001473 ! lymphatic vessel +created_by: tmeehan +creation_date: 2010-08-24T02:05:28Z + [Term] id: CL:0002139 name: endothelial cell of vascular tree @@ -27251,6 +48322,9 @@ xref: FMA:70953 is_a: CL:0000317 {is_inferred="true"} ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland +intersection_of: CL:0000317 ! sebum secreting cell +intersection_of: part_of UBERON:0003487 ! skin sebaceous gland +relationship: part_of UBERON:0003487 ! skin sebaceous gland created_by: tmeehan creation_date: 2010-08-24T09:27:52Z @@ -27262,13 +48336,55 @@ def: "An endothelial cell found in capillaries." [GOC:tfm] xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 -is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell +is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary created_by: tmeehan creation_date: 2010-08-24T10:15:00Z +[Term] +id: CL:0002145 +name: ciliated columnar cell of tracheobronchial tree +namespace: cell +def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] +xref: FMA:70542 +is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +is_a: CL:0005012 ! multi-ciliated epithelial cell +relationship: develops_from CL:0002209 ! intermediate epitheliocyte +created_by: tmeehan +creation_date: 2010-08-24T03:38:29Z + +[Term] +id: CL:0002148 +name: dental pulp cell +namespace: cell +def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820] +xref: BTO:0000339 +xref: CALOHA:TS-0195 +xref: FMA:87170 +is_a: CL:0002159 ! general ecto-epithelial cell +is_a: CL:0002320 ! connective tissue cell +intersection_of: CL:0002159 ! general ecto-epithelial cell +intersection_of: part_of UBERON:0001754 ! dental pulp +relationship: part_of UBERON:0001754 ! dental pulp +created_by: tmeehan +creation_date: 2010-08-24T02:52:09Z + +[Term] +id: CL:0002149 +name: epithelial cell of uterus +namespace: cell +alt_id: CL:1000294 +def: "An epithelial cell of the uterus." [GOC:tfm] +xref: FMA:256161 +is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell +intersection_of: CL:0002076 ! endo-epithelial cell +intersection_of: part_of UBERON:0000995 ! uterus +relationship: part_of UBERON:0000995 ! uterus +created_by: tmeehan +creation_date: 2010-08-24T10:45:54Z + [Term] id: CL:0002159 name: general ecto-epithelial cell @@ -27282,7 +48398,6 @@ creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002165 name: phalangeal cell -namespace: cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell @@ -27297,6 +48412,9 @@ def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMI xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z @@ -27307,9 +48425,13 @@ namespace: cell alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] synonym: "horizontal basal call" BROAD [] +synonym: "horizontal basal cell" BROAD [] xref: FMA:62303 is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell is_a: CL:0002319 ! neural cell +intersection_of: CL:0002167 ! olfactory epithelial cell +intersection_of: part_of UBERON:0001997 ! olfactory epithelium +relationship: part_of UBERON:0001997 ! olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:58:54Z @@ -27330,7 +48452,6 @@ creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium -namespace: cell def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 @@ -27341,7 +48462,6 @@ creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea -namespace: cell def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803] synonym: "interdental cell" EXACT [] xref: FMA:79797 @@ -27352,7 +48472,6 @@ creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell -namespace: cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] @@ -27360,7 +48479,6 @@ synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell -is_a: CL:1000500 ! kidney interstitial cell is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell is_a: CL:1001318 ! renal interstitial pericyte created_by: tmeehan @@ -27373,10 +48491,29 @@ namespace: cell def: "A cell within the follicle of an ovary." [GOC:tfm] xref: EMAPA:31247 xref: FMA:70589 +is_a: CL:0000500 ! follicular epithelial cell is_a: CL:0002078 ! meso-epithelial cell +property_value: RO:0002161 NCBITaxon:50557 {source="https://github.com/obophenotype/cell-ontology/issues/589"} created_by: tmeehan creation_date: 2010-08-25T03:01:27Z +[Term] +id: CL:0002177 +name: folliculostellate cell of pars distalis of adenohypophysis +namespace: cell +def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] +synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] +xref: FMA:83102 +is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell +is_a: CL:0000710 ! neurecto-epithelial cell +is_a: CL:0002319 ! neural cell +is_a: CL:2000004 ! pituitary gland cell +intersection_of: CL:0000642 ! folliculostellate cell +intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis +relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis +created_by: tmeehan +creation_date: 2010-08-25T03:10:10Z + [Term] id: CL:0002178 name: epithelial cell of stomach @@ -27408,7 +48545,6 @@ creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002182 name: surface mucosal cell of stomach -namespace: cell def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell @@ -27435,7 +48571,6 @@ creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium -namespace: cell def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 @@ -27459,6 +48594,21 @@ intersection_of: part_of UBERON:0001003 ! skin epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z +[Term] +id: CL:0002188 +name: glomerular endothelial cell +namespace: cell +def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] +xref: BTO:0004632 +xref: FMA:70970 +is_a: CL:0000115 {is_inferred="true"} ! endothelial cell +is_a: CL:0000666 ! fenestrated cell +is_a: CL:1000746 ! glomerular cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0000074 ! renal glomerulus +created_by: tmeehan +creation_date: 2010-08-26T10:59:44Z + [Term] id: CL:0002191 name: granulocytopoietic cell @@ -27490,21 +48640,29 @@ id: CL:0002195 name: hepatic stem cell namespace: cell def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm] +def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] +synonym: "HpSC" EXACT abbreviation [PMID:18442648] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell +intersection_of: CL:0000048 ! multi fate stem cell +intersection_of: part_of UBERON:0002107 ! liver +relationship: part_of UBERON:0002107 ! liver +property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell -namespace: cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986] synonym: "hepatic oval cell" EXACT [] +synonym: "hepatic progenitor cell" EXACT [https://doi.org/10.1038/s12276-020-0483-0] {http://purl.org/dc/elements/1.1/contributor="http://orcid.org/000-0003-1940-6740"} +synonym: "liver progenitor cell" EXACT [https://doi.org/10.1038/s12276-020-0483-0] xref: BTO:0004270 xref: FMA:86576 -is_a: CL:0002195 ! hepatic stem cell +is_a: CL:0011026 ! progenitor cell +property_value: RO:0004050 "Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': \"... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)\"." xsd:string {xref="https://doi.org/10.1038/s12276-020-0483-0", xref="https://doi.org/10.3389/fcell.2021.644088"} created_by: tmeehan creation_date: 2010-08-30T02:01:49Z @@ -27516,13 +48674,26 @@ alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree +relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:09:14Z +[Term] +id: CL:0002209 +name: intermediate epitheliocyte +namespace: cell +def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] +synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] +xref: FMA:69060 +is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +created_by: tmeehan +creation_date: 2010-09-02T02:53:59Z + [Term] id: CL:0002210 name: red muscle cell -namespace: cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] @@ -27534,20 +48705,18 @@ creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell -namespace: cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] -synonym: "intermediate muscle fiber" RELATED [MESH:A02.633.565.700] +synonym: "intermediate muscle fiber" RELATED [MESH:D018657] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] -synonym: "slow twitch muscle fiber" RELATED [MESH:A02.633.565.700] -synonym: "slow-twitch muscle fiber" RELATED [MESH:A02.633.565.700] +synonym: "slow twitch muscle fiber" EXACT [MESH:D018657] +synonym: "slow-twitch muscle fiber" EXACT [MESH:D018657] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 -xref: MESH:A02.633.565.700 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan @@ -27556,7 +48725,6 @@ creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell -namespace: cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] @@ -27570,7 +48738,6 @@ creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell -namespace: cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell @@ -27580,7 +48747,6 @@ creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell -namespace: cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] @@ -27597,7 +48763,6 @@ creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell -namespace: cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] @@ -27611,7 +48776,6 @@ creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor -namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] @@ -27620,13 +48784,22 @@ is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z +[Term] +id: CL:0002220 +name: interstitial cell of pineal gland +namespace: cell +def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] +xref: FMA:86575 +is_a: CL:0000710 ! neurecto-epithelial cell +created_by: tmeehan +creation_date: 2010-09-02T04:28:41Z + [Term] id: CL:0002222 name: vertebrate lens cell namespace: cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] xref: FMA:70950 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002371 ! somatic cell @@ -27637,7 +48810,6 @@ creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell -namespace: cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651] xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell @@ -27661,7 +48833,6 @@ creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber -namespace: cell def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] synonym: "secondary lens fibre" EXACT [] is_a: CL:0011004 ! lens fiber cell @@ -27672,7 +48843,6 @@ creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002228 name: primary lens fiber -namespace: cell def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 @@ -27681,6 +48851,54 @@ relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z +[Term] +id: CL:0002231 +name: epithelial cell of prostate +namespace: cell +alt_id: CL:1000295 +alt_id: CL:1000408 +def: "An epithelial cell of the prostate." [GOC:tfm] +synonym: "prostate epithelial cell" EXACT [] +xref: FMA:256163 +xref: FMA:66817 +is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell +intersection_of: CL:0002076 ! endo-epithelial cell +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland +created_by: tmeehan +creation_date: 2010-09-07T01:49:29Z + +[Term] +id: CL:0002232 +name: epithelial cell of prostatic duct +namespace: cell +alt_id: CL:1000462 +def: "An epithelial cell of prostatic duct." [GOC:tfm] +synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224] +xref: FMA:74224 +is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell +is_a: CL:0002231 ! epithelial cell of prostate +intersection_of: CL:0000072 ! non-branched duct epithelial cell +intersection_of: part_of UBERON:0002485 ! prostate duct +relationship: part_of UBERON:0002485 ! prostate duct +created_by: tmeehan +creation_date: 2010-09-07T01:55:51Z + +[Term] +id: CL:0002236 +name: basal epithelial cell of prostatic duct +namespace: cell +alt_id: CL:1000463 +def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] +xref: FMA:74226 +is_a: CL:0000068 ! duct epithelial cell +is_a: CL:0002341 ! basal cell of prostate epithelium +intersection_of: CL:0002341 ! basal cell of prostate epithelium +intersection_of: part_of UBERON:0002485 ! prostate duct +relationship: part_of UBERON:0002485 ! prostate duct +created_by: tmeehan +creation_date: 2010-09-07T01:59:12Z + [Term] id: CL:0002240 name: marrow fibroblast @@ -27694,6 +48912,23 @@ intersection_of: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-09-07T02:25:18Z +[Term] +id: CL:0002241 +name: pulmonary interstitial fibroblast +namespace: cell +def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] +synonym: "pulmonary myofibroblast" EXACT [] +synonym: "pulmonary septal cell" EXACT [] +xref: FMA:84467 +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001004 ! respiratory system +intersection_of: part_of UBERON:0005169 ! interstitial tissue +relationship: part_of UBERON:0001004 ! respiratory system +relationship: part_of UBERON:0005169 ! interstitial tissue +created_by: tmeehan +creation_date: 2010-09-07T02:29:38Z + [Term] id: CL:0002242 name: nucleate cell @@ -27707,6 +48942,22 @@ relationship: bearer_of PATO:0002505 ! nucleated created_by: tmeehan creation_date: 2010-09-07T03:32:33Z +[Term] +id: CL:0002243 +name: smooth muscle cell of sphincter of pupil +namespace: cell +def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] +synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] +synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] +xref: FMA:70611 +is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001607 ! sphincter pupillae +relationship: develops_from CL:0000133 ! neurectodermal cell +relationship: part_of UBERON:0001607 ! sphincter pupillae +created_by: tmeehan +creation_date: 2010-09-08T08:53:42Z + [Term] id: CL:0002246 name: peripheral blood stem cell @@ -27715,6 +48966,7 @@ def: "A hematopoeitic stem cell found in the blood. Normally found in very limit synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 +xref: MESH:D000072916 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell @@ -27759,6 +49011,9 @@ synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: part_of UBERON:0000059 ! large intestine +relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-08T09:28:22Z @@ -27770,9 +49025,54 @@ alt_id: CL:1000293 def: "An epithelial cell of the small intestine." [GOC:tfm] xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-08T09:41:46Z +[Term] +id: CL:0002255 +name: stromal cell of endometrium +namespace: cell +def: "Connective tissue cells of the endometrium, these cells are fibroblastic in appearance. During decidualization they tranform into decidual (stromal) cells, swellling up and adopt an epithelial cell-like appearance due to the accumulation of glycogen and lipid droplets." [PMID:11331626, PMID:30013421, Wiki:Decidualization&oldid=908981933#Endometrial_stromal_cells_(ESCs)] +synonym: "endometrial stromal cell" EXACT [] +xref: CALOHA:TS-1266 +xref: FMA:86490 +is_a: CL:0000499 {is_inferred="true"} ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0001295 ! endometrium +relationship: part_of UBERON:0001295 ! endometrium +created_by: tmeehan +creation_date: 2010-09-08T09:50:04Z + +[Term] +id: CL:0002256 +name: supporting cell of carotid body +namespace: cell +def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136] +synonym: "carotid body sustentacular cell" EXACT [] +xref: FMA:84188 +is_a: CL:0000630 ! supporting cell +is_a: CL:0000710 ! neurecto-epithelial cell +created_by: tmeehan +creation_date: 2010-09-08T10:34:45Z + +[Term] +id: CL:0002257 +name: epithelial cell of thyroid gland +namespace: cell +alt_id: CL:1000297 +def: "An epithelial cell of thyroid gland." [GOC:tfm] +xref: FMA:256167 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell +intersection_of: CL:0002076 ! endo-epithelial cell +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland +created_by: tmeehan +creation_date: 2010-09-08T01:46:51Z + [Term] id: CL:0002260 name: epithelial cell of parathyroid gland @@ -27782,6 +49082,8 @@ def: "An epithelial cell of the parathyroid gland." [GOC:tfm] xref: FMA:70547 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell is_a: CL:1001593 ! parathyroid glandular cell +intersection_of: CL:0002076 ! endo-epithelial cell +intersection_of: part_of UBERON:0001132 ! parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:29:38Z @@ -27823,15 +49125,129 @@ intersection_of: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-09-10T10:54:42Z +[Term] +id: CL:0002265 +name: type D cell of colon +namespace: cell +def: "A D cell located in the colon." [GOC:tfm] +synonym: "colon D-cell" EXACT [] +synonym: "colonic delta cell" EXACT [] +synonym: "delta cell of colon" EXACT [] +xref: FMA:268744 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009042 ! enteroendocrine cell of colon +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: part_of UBERON:0001155 ! colon +created_by: tmeehan +creation_date: 2010-09-10T11:37:35Z + +[Term] +id: CL:0002266 +name: type D cell of small intestine +namespace: cell +def: "A type D cell of the small intestine." [GOC:tfm] +synonym: "delta cell of small intestine" EXACT [] +synonym: "small intestine D-cell" EXACT [] +synonym: "small intestine delta cell" EXACT [] +xref: FMA:268736 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009006 ! enteroendocrine cell of small intestine +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: part_of UBERON:0002108 ! small intestine +created_by: tmeehan +creation_date: 2010-09-10T01:34:22Z + +[Term] +id: CL:0002267 +name: type D cell of stomach +namespace: cell +def: "A type D cell found in the stomach." [GOC:tfm] +synonym: "delta cell of stomach" EXACT [] +synonym: "stomach D-cell" EXACT [] +synonym: "stomach delta cell" EXACT [] +xref: FMA:83410 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0002659 ! glandular cell of stomach +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: part_of UBERON:0000945 ! stomach +created_by: tmeehan +creation_date: 2010-09-10T01:36:03Z + [Term] id: CL:0002274 name: histamine secreting cell namespace: cell def: "A cell type that secretes histamine." [GOC:tfm] is_a: CL:0000457 ! biogenic amine secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: capable_of GO:0001821 ! histamine secretion +relationship: capable_of GO:0001821 ! histamine secretion created_by: tmeehan creation_date: 2010-09-10T03:04:42Z +[Term] +id: CL:0002275 +name: pancreatic PP cell +namespace: cell +def: "A PP cell located in the islets of the pancreas." [GOC:tfm] +comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. +synonym: "pancreatic polypeptide-secreting cell" EXACT [] +synonym: "PP cell of pancreatic islet" EXACT [] +synonym: "PP-cell of pancreatic islet" EXACT [] +xref: BTO:0000805 +xref: FMA:70588 +xref: MESH:D050418 +is_a: CL:0000083 ! epithelial cell of pancreas +is_a: CL:0000696 ! PP cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: part_of UBERON:0000006 ! islet of Langerhans +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0000006 ! islet of Langerhans +created_by: tmeehan +creation_date: 2010-09-10T03:30:31Z + +[Term] +id: CL:0002292 +name: type I cell of carotid body +namespace: cell +def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] +synonym: "glomus cell" EXACT [] +xref: FMA:84186 +is_a: CL:0000710 ! neurecto-epithelial cell +created_by: tmeehan +creation_date: 2010-09-13T01:40:21Z + +[Term] +id: CL:0002293 +name: epithelial cell of thymus +namespace: cell +alt_id: CL:1000459 +def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] +synonym: "epithelial cell of thymus gland" EXACT [] +synonym: "epithelial reticular cell" EXACT [] +synonym: "epithelial reticular cell of thymus" EXACT [] +synonym: "thymic epithelial cell" EXACT [] +xref: CALOHA:TS-1040 +xref: FMA:72208 +is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell +intersection_of: CL:0002076 ! endo-epithelial cell +intersection_of: part_of UBERON:0002370 ! thymus +relationship: part_of UBERON:0002370 ! thymus +created_by: tmeehan +creation_date: 2010-09-13T02:34:22Z + +[Term] +id: CL:0002294 +name: type-1 epithelial cell of thymus +namespace: cell +def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] +synonym: "subcapsular thymic epithelial cell" EXACT [] +xref: FMA:72209 +is_a: CL:0002364 ! cortical thymic epithelial cell +created_by: tmeehan +creation_date: 2010-09-13T02:37:23Z + [Term] id: CL:0002303 name: pigmented ciliary epithelial cell @@ -27844,6 +49260,39 @@ is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z +[Term] +id: CL:0002305 +name: epithelial cell of distal tubule +namespace: cell +def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] +synonym: "kidney distal tubule epithelial cell" EXACT [] +xref: FMA:62125 +xref: FMA:70981 +xref: KUPO:0001055 +is_a: CL:0002078 ! meso-epithelial cell +is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell +is_a: CL:1000615 ! kidney cortex tubule cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0004135 ! distal tubule +relationship: part_of UBERON:0004135 ! distal tubule + +[Term] +id: CL:0002306 +name: epithelial cell of proximal tubule +namespace: cell +def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] +synonym: "kidney proximal tubule epithelial cell" EXACT [] +xref: FMA:62125 +xref: FMA:70973 +xref: KUPO:0001044 +is_a: CL:0000239 ! brush border epithelial cell +is_a: CL:0002078 ! meso-epithelial cell +is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell +is_a: CL:1000615 ! kidney cortex tubule cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0004134 ! proximal tubule +relationship: part_of UBERON:0004134 ! proximal tubule + [Term] id: CL:0002308 name: epithelial cell of skin gland @@ -27858,10 +49307,43 @@ relationship: part_of UBERON:0002419 ! skin gland created_by: tmeehan creation_date: 2010-09-14T12:00:07Z +[Term] +id: CL:0002312 +name: somatotroph +namespace: cell +def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] +synonym: "somatotrope" EXACT [] +synonym: "somatotropic cell" EXACT [] +synonym: "somatrophic cell" EXACT [] +xref: FMA:83095 +is_a: CL:0000295 ! somatotropin secreting cell +is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis +created_by: tmeehan +creation_date: 2010-09-14T02:33:09Z + +[Term] +id: CL:0002313 +name: endocrine-paracrine cell of prostate gland +namespace: cell +def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] +synonym: "glandular cell of prostate" EXACT [] +synonym: "neuro-epithelial cell of prostate gland" EXACT [] +xref: CALOHA:TS-1280 +xref: FMA:74390 +xref: FMA:86774 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002159 ! general ecto-epithelial cell +intersection_of: CL:0002159 ! general ecto-epithelial cell +intersection_of: capable_of GO:0046879 ! hormone secretion +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: capable_of GO:0046879 ! hormone secretion +relationship: part_of UBERON:0002367 ! prostate gland +created_by: tmeehan +creation_date: 2010-09-14T03:01:58Z + [Term] id: CL:0002315 name: supporting cell of cochlea -namespace: cell def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] xref: FMA:79796 is_a: CL:0001035 ! bone cell @@ -27876,7 +49358,6 @@ namespace: cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2040 xref: FMA:70333 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell @@ -27893,7 +49374,7 @@ alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2096 xref: FMA:63875 -is_a: BFO:0000004 ! independent continuant +xref: MESH:D003239 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell @@ -27915,6 +49396,60 @@ is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z +[Term] +id: CL:0002324 +name: myoepithelial cell of mammary gland +namespace: cell +def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771] +synonym: "basal cell of lactiferous duct" EXACT [FMA:67800] +synonym: "myoepithelial cell of lactiferous gland" EXACT [] +xref: CALOHA:TS-2378 +xref: FMA:67800 +is_a: CL:0000185 ! myoepithelial cell +is_a: CL:0002327 ! mammary gland epithelial cell +intersection_of: CL:0000185 ! myoepithelial cell +intersection_of: part_of UBERON:0001911 ! mammary gland +created_by: tmeehan +creation_date: 2010-09-20T11:42:14Z + +[Term] +id: CL:0002325 +name: mammary alveolar cell +namespace: cell +alt_id: CL:0002230 +alt_id: CL:1000476 +def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771] +synonym: "epithelial cell of lactiferous gland" EXACT [] +synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] +synonym: "mammary alveolar epithelial cell" EXACT [] +synonym: "mammary gland alveolar epithelial cell" EXACT [] +xref: FMA:74506 +xref: FMA:79866 +is_a: CL:0000314 ! milk secreting cell +is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell +is_a: CL:1001586 ! mammary gland glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0003214 ! mammary gland alveolus +relationship: part_of UBERON:0003214 ! mammary gland alveolus +created_by: tmeehan +creation_date: 2010-09-20T01:30:57Z + +[Term] +id: CL:0002327 +name: mammary gland epithelial cell +namespace: cell +def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] +synonym: "breast epithelial cell" EXACT [] +synonym: "mammary epithelial cell" EXACT [] +xref: BTO:0004300 +is_a: CL:0000066 ! epithelial cell +is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0001911 ! mammary gland +created_by: tmeehan +creation_date: 2010-09-20T01:49:37Z + [Term] id: CL:0002328 name: bronchial epithelial cell @@ -27922,18 +49457,32 @@ namespace: cell def: "An epithelial cell of the bronchus." [GOC:tfm] xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree -namespace: cell def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z +[Term] +id: CL:0002332 +name: ciliated cell of the bronchus +namespace: cell +def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] +is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree +is_a: CL:0002328 ! bronchial epithelial cell +intersection_of: CL:0000064 ! ciliated cell +intersection_of: part_of UBERON:0002185 ! bronchus +created_by: tmeehan +creation_date: 2010-09-20T02:21:12Z + [Term] id: CL:0002333 name: neural crest derived fat cell @@ -27949,7 +49498,6 @@ creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte -namespace: cell def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] xref: BTO:0001107 is_a: CL:0000057 ! fibroblast @@ -27959,7 +49507,6 @@ creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte -namespace: cell def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] is_a: CL:0002334 ! preadipocyte created_by: tmeehan @@ -27969,15 +49516,37 @@ creation_date: 2010-09-20T02:38:38Z id: CL:0002336 name: buccal mucosa cell namespace: cell +def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:D009061] def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z +[Term] +id: CL:0002339 +name: prostate stem cell +namespace: cell +def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] +synonym: "CD133-positive prostate epithelial cell" EXACT [] +is_a: CL:0000048 ! multi fate stem cell +is_a: CL:0002341 ! basal cell of prostate epithelium +intersection_of: CL:0000034 ! stem cell +intersection_of: part_of UBERON:0002367 ! prostate gland +created_by: tmeehan +creation_date: 2010-09-20T03:21:06Z + +[Term] +id: CL:0002341 +name: basal cell of prostate epithelium +namespace: cell +def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] +is_a: CL:0002231 ! epithelial cell of prostate +created_by: tmeehan +creation_date: 2010-09-20T03:34:10Z + [Term] id: CL:0002343 name: decidual natural killer cell, human -namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] @@ -28027,7 +49596,6 @@ creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell -namespace: cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell created_by: tmeehan @@ -28036,7 +49604,6 @@ creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell -namespace: cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell @@ -28046,7 +49613,6 @@ creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell -namespace: cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] @@ -28059,7 +49625,6 @@ creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte -namespace: cell def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] synonym: "macrocyte" EXACT [] is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte @@ -28067,10 +49632,21 @@ relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor ce created_by: tmeehan creation_date: 2010-09-22T09:38:32Z +[Term] +id: CL:0002359 +name: placental hematopoietic stem cell +namespace: cell +def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] +is_a: CL:0002352 ! gestational hematopoietic stem cell +intersection_of: CL:0000037 ! hematopoietic stem cell +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta +created_by: tmeehan +creation_date: 2010-09-22T10:30:02Z + [Term] id: CL:0002361 name: primitive erythroid progenitor -namespace: cell def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] @@ -28093,6 +49669,48 @@ relationship: part_of UBERON:0001777 ! substantia propria of cornea created_by: tmeehan creation_date: 2010-09-22T01:57:40Z +[Term] +id: CL:0002364 +name: cortical thymic epithelial cell +namespace: cell +def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] +synonym: "cTEC" EXACT [] +xref: BTO:0004562 +is_a: CL:0002293 ! epithelial cell of thymus +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002123 ! cortex of thymus +relationship: part_of UBERON:0002123 ! cortex of thymus +created_by: tmeehan +creation_date: 2010-09-23T03:17:12Z + +[Term] +id: CL:0002365 +name: medullary thymic epithelial cell +namespace: cell +def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] +synonym: "mTEC" EXACT [] +xref: BTO:0004563 +is_a: CL:0002293 ! epithelial cell of thymus +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002124 ! medulla of thymus +relationship: part_of UBERON:0002124 ! medulla of thymus +created_by: tmeehan +creation_date: 2010-09-23T03:17:14Z + +[Term] +id: CL:0002366 +name: myometrial cell +namespace: cell +def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] +synonym: "myometrium smooth muscle cell" EXACT [] +xref: BTO:0004519 +is_a: CL:0002601 ! uterine smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001296 ! myometrium +relationship: part_of UBERON:0001296 ! myometrium +created_by: tmeehan +creation_date: 2010-09-23T03:46:34Z + [Term] id: CL:0002368 name: respiratory epithelial cell @@ -28114,6 +49732,9 @@ namespace: cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863] is_a: CL:0000160 ! goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0000065 ! respiratory tract +relationship: part_of UBERON:0004802 ! respiratory tract epithelium created_by: tmeehan creation_date: 2010-09-23T04:42:27Z @@ -28138,6 +49759,7 @@ alt_id: CL:0000369 def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] +xref: FBbt:00005812 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell @@ -28151,7 +49773,6 @@ creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002374 name: ear hair cell -namespace: cell def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023] synonym: "ear receptor cell" EXACT [] is_a: CL:0000006 ! neuronal receptor cell @@ -28162,7 +49783,6 @@ creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor -namespace: cell def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast @@ -28174,7 +49794,6 @@ creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002377 name: immature Schwann cell -namespace: cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 @@ -28186,7 +49805,6 @@ creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor -namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] @@ -28199,7 +49817,6 @@ creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002404 name: fetal thymocyte -namespace: cell def: "A thymocyte found in the fetal thymus." [GOC:tfm] is_a: CL:0000893 ! thymocyte created_by: tmeehan @@ -28208,7 +49825,6 @@ creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002417 name: primitive erythroid lineage cell -namespace: cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan @@ -28217,8 +49833,8 @@ creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast -namespace: cell def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] +xref: MESH:D055018 is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan @@ -28227,7 +49843,6 @@ creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell -namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] @@ -28245,6 +49860,9 @@ synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 {is_inferred="true"} ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: has_not_completed GO:0045058 ! T cell selection +relationship: has_not_completed GO:0045058 ! T cell selection created_by: tmeehan creation_date: 2010-10-12T01:56:17Z @@ -28295,6 +49913,9 @@ namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte +intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte +intersection_of: bearer_of PATO:0000587 ! decreased size +relationship: bearer_of PATO:0000587 ! decreased size created_by: tmeehan creation_date: 2010-10-21T01:59:06Z @@ -28306,7 +49927,12 @@ def: "A double-positive thymocyte that is large (i.e. has a high forward scatter synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte +intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte +intersection_of: bearer_of PATO:0000586 ! increased size +intersection_of: participates_in GO:0008283 ! cell population proliferation +relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002427 ! resting double-positive thymocyte +relationship: participates_in GO:0008283 ! cell population proliferation created_by: tmeehan creation_date: 2010-10-21T01:59:11Z @@ -28318,6 +49944,8 @@ def: "A double-positive thymocyte that is CD69-positive and has begun positive s synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002428 ! double-positive blast +relationship: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex +relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:11:52Z @@ -28327,8 +49955,11 @@ name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.Th" EXACT [] +synonym: "T_4int8+_Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex +relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:19Z @@ -28337,9 +49968,12 @@ id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] -synonym: "T.4int8+.th" EXACT [] +synonym: "T.4+8int.Th" EXACT [] +synonym: "T_4+8int_Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex +relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:23Z @@ -28353,6 +49987,7 @@ synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T02:43:52Z @@ -28365,6 +50000,7 @@ synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T02:46:02Z @@ -28378,6 +50014,7 @@ synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T02:59:10Z @@ -28390,6 +50027,7 @@ synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T02:59:14Z @@ -28401,6 +50039,7 @@ def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T03:31:19Z @@ -28412,26 +50051,29 @@ def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte +relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell -namespace: cell -def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:20142420] -is_a: CL:0000123 {is_inferred="true"} ! neuron associated cell (sensu Vertebrata) -intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata) -intersection_of: part_of UBERON:0001017 ! central nervous system +def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:10704434, PMID:11756508, PMID:20142420, PMID:2182078, PMID:24133281, PMID:9826671] +comment: This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). {xref="PMID:10704434", xref="ISBN:9780702028991", xref="PMID:2182078"} +synonym: "O-2A/OPC" BROAD [PMID:24133281] +synonym: "O2A/OPC" BROAD [PMID:11756508] +synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD [PMID:2253328] +synonym: "oligodendrocyte/type-2 astrocyte progenitor cell" BROAD [PMID:24133281] {http://purl.org/dc/terms/contributor="http://orcid.org/0000-0002-0819-0473"} +xref: MESH:D000073637 +is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) -relationship: part_of UBERON:0001017 ! central nervous system +property_value: dc-contributor http://orcid.org/0000-0002-1773-2692 xsd:string created_by: tmeehan creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell -namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] @@ -28447,7 +50089,6 @@ creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell -namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell @@ -28463,6 +50104,9 @@ namespace: cell def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm] xref: MP:0002262 is_a: CL:0002370 ! respiratory goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa +relationship: part_of UBERON:0005384 ! nasal cavity epithelium created_by: tmeehan creation_date: 2010-12-03T03:03:02Z @@ -28473,6 +50117,8 @@ namespace: cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420] is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell is_a: CL:0002625 ! seminiferous tubule epithelial cell +intersection_of: CL:0000185 ! myoepithelial cell +intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis created_by: tmeehan creation_date: 2010-12-03T03:11:48Z @@ -28488,6 +50134,18 @@ relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2010-12-03T03:17:05Z +[Term] +id: CL:0002483 +name: hair follicle melanocyte +namespace: cell +def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381] +is_a: CL:0002559 ! hair follicle cell +is_a: CL:2000000 ! epidermal melanocyte +intersection_of: CL:0000148 ! melanocyte +intersection_of: part_of UBERON:0002073 ! hair follicle +created_by: tmeehan +creation_date: 2010-12-03T03:17:09Z + [Term] id: CL:0002484 name: epithelial melanocyte @@ -28516,7 +50174,6 @@ creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell -namespace: cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048] is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0002484 ! epithelial melanocyte @@ -28527,7 +50184,6 @@ creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell -namespace: cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973] is_a: CL:0000199 ! mechanoreceptor cell created_by: tmeehan @@ -28536,7 +50192,6 @@ creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell -namespace: cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell @@ -28558,7 +50213,6 @@ creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell -namespace: cell def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan @@ -28570,13 +50224,15 @@ name: auditory epithelial cell namespace: cell def: "A specialized cell involved in auditory sensory perception." [GOC:tfm] is_a: CL:0000098 ! sensory epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound +relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound created_by: tmeehan creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell -namespace: cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366] is_a: CL:0002491 ! auditory epithelial cell created_by: tmeehan @@ -28585,7 +50241,6 @@ creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell -namespace: cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] is_a: CL:0002491 ! auditory epithelial cell @@ -28603,7 +50258,6 @@ xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 -is_a: BFO:0000004 ! independent continuant is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell @@ -28615,7 +50269,6 @@ creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte -namespace: cell def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788] synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] @@ -28626,11 +50279,11 @@ creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte -namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] +xref: MESH:D000075942 is_a: CL:0002419 {is_inferred="true"} ! mature T cell created_by: tmeehan creation_date: 2010-12-07T09:54:50Z @@ -28638,7 +50291,6 @@ creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002499 name: spongiotrophoblast cell -namespace: cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959] synonym: "spongiotrophoblast" EXACT [] is_a: CL:0000351 ! trophoblast cell @@ -28660,6 +50312,19 @@ relationship: part_of UBERON:0005742 ! adventitia created_by: tmeehan creation_date: 2010-12-07T04:03:56Z +[Term] +id: CL:0002504 +name: enteric smooth muscle cell +namespace: cell +def: "A smooth muscle cell of the intestine." [GOC:tfm] +synonym: "intestinal smooth muscle cell" EXACT [] +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0000160 ! intestine +relationship: part_of UBERON:0000160 ! intestine +created_by: tmeehan +creation_date: 2011-01-17T03:39:38Z + [Term] id: CL:0002518 name: kidney epithelial cell @@ -28668,6 +50333,8 @@ def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ] xref: KUPO:0001019 is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002113 ! kidney created_by: tmeehan creation_date: 2011-02-08T10:46:34Z @@ -28687,12 +50354,75 @@ creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell -namespace: cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm] is_a: CL:0000424 ! excretory cell created_by: tmeehan creation_date: 2011-02-08T01:37:59Z +[Term] +id: CL:0002535 +name: epithelial cell of cervix +namespace: cell +def: "An epithelial cell of the cervix." [GOC:tfm] +synonym: "cervical canal epithelial cell" EXACT [GOC:tfm] +synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm] +synonym: "cervix epithelial cell" EXACT [GOC:tfm] +synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm] +synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm] +synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm] +synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm] +synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm] +synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm] +synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm] +synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm] +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: part_of UBERON:0004801 ! cervix epithelium +created_by: tmeehan +creation_date: 2011-02-24T08:20:08Z + +[Term] +id: CL:0002536 +name: epithelial cell of amnion +namespace: cell +def: "An epithelial cell that is part of the amnion." [GOC:tfm] +synonym: "amniotic epithelial cell" EXACT [] +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 {is_inferred="true"} ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0000305 ! amnion +relationship: part_of UBERON:0000305 ! amnion +created_by: tmeehan +creation_date: 2011-02-28T12:38:01Z + +[Term] +id: CL:0002537 +name: amnion mesenchymal stem cell +namespace: cell +def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039] +synonym: "amniotic membrane stem cell" EXACT [] +is_a: CL:0000134 ! mesenchymal stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0000305 ! amnion +relationship: part_of UBERON:0000305 ! amnion +created_by: tmeehan +creation_date: 2011-02-28T12:44:24Z + +[Term] +id: CL:0002538 +name: intrahepatic cholangiocyte +namespace: cell +def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] +synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296] +is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium +relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium +created_by: tmeehan +creation_date: 2011-02-28T01:20:20Z + [Term] id: CL:0002539 name: aortic smooth muscle cell @@ -28718,6 +50448,18 @@ intersection_of: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2011-02-28T01:47:47Z +[Term] +id: CL:0002541 +name: chorionic membrane mesenchymal stem cell +namespace: cell +def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0003124 ! chorion membrane +relationship: part_of UBERON:0003124 ! chorion membrane +created_by: tmeehan +creation_date: 2011-02-28T03:04:35Z + [Term] id: CL:0002543 name: vein endothelial cell @@ -28772,6 +50514,31 @@ relationship: part_of UBERON:0000948 ! heart created_by: tmeehan creation_date: 2011-02-28T04:57:44Z +[Term] +id: CL:0002549 +name: fibroblast of choroid plexus +namespace: cell +def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +is_a: CL:0002319 ! neural cell +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001886 ! choroid plexus +relationship: part_of UBERON:0001886 ! choroid plexus +created_by: tmeehan +creation_date: 2011-02-28T05:01:39Z + +[Term] +id: CL:0002550 +name: fibroblast of the conjunctiva +namespace: cell +def: "A fibroblast that is part of the conjuctiva of the eye." [GOC:tfm] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001811 ! conjunctiva +relationship: part_of UBERON:0001811 ! conjunctiva +created_by: tmeehan +creation_date: 2011-02-28T05:03:44Z + [Term] id: CL:0002551 name: fibroblast of dermis @@ -28783,6 +50550,17 @@ relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2011-02-28T05:05:33Z +[Term] +id: CL:0002552 +name: fibroblast of gingiva +namespace: cell +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001828 ! gingiva +relationship: part_of UBERON:0001828 ! gingiva +created_by: tmeehan +creation_date: 2011-02-28T05:09:12Z + [Term] id: CL:0002553 name: fibroblast of lung @@ -28797,6 +50575,42 @@ relationship: part_of UBERON:0002048 ! lung created_by: tmeehan creation_date: 2011-02-28T05:11:03Z +[Term] +id: CL:0002554 +name: fibroblast of lymphatic vessel +namespace: cell +def: "A fibroblast of the lymphatic system." [GOC:tfm] +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001473 ! lymphatic vessel +relationship: part_of UBERON:0001473 ! lymphatic vessel +created_by: tmeehan +creation_date: 2011-02-28T05:16:18Z + +[Term] +id: CL:0002555 +name: fibroblast of mammary gland +namespace: cell +def: "A fibroblast that is part of the mammary gland." [GOC:tfm] +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0001911 ! mammary gland +created_by: tmeehan +creation_date: 2011-02-28T05:18:38Z + +[Term] +id: CL:0002556 +name: fibroblast of periodontium +namespace: cell +def: "A fibroblast of the periodontium." [GOC:tfm] +is_a: CL:0000057 {is_inferred="true"} ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001758 ! periodontium +relationship: part_of UBERON:0001758 ! periodontium +created_by: tmeehan +creation_date: 2011-02-28T05:19:48Z + [Term] id: CL:0002557 name: fibroblast of pulmonary artery @@ -28809,15 +50623,55 @@ relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-02-28T05:22:27Z +[Term] +id: CL:0002559 +name: hair follicle cell +namespace: cell +def: "An animal cell that is part of a hair follicle." [GOC:tfm] +is_a: CL:0002371 {is_inferred="true"} ! somatic cell +intersection_of: CL:0002371 ! somatic cell +intersection_of: part_of UBERON:0002073 ! hair follicle +relationship: part_of UBERON:0002073 ! hair follicle +created_by: tmeehan +creation_date: 2011-03-01T04:11:01Z + [Term] id: CL:0002563 name: intestinal epithelial cell namespace: cell def: "An epithelial cell of the intestine." [GOC:tfm] is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0000160 ! intestine +relationship: part_of UBERON:0001277 ! intestinal epithelium created_by: tmeehan creation_date: 2011-03-01T05:18:31Z +[Term] +id: CL:0002564 +name: nucleus pulposus cell of intervertebral disc +namespace: cell +def: "A connective tissue cell of the nucleus pulposus cell of intervertebral disc." [GOC:tfm] +is_a: CL:0002320 ! connective tissue cell +intersection_of: CL:0002320 ! connective tissue cell +intersection_of: part_of UBERON:0002242 ! nucleus pulposus +relationship: part_of UBERON:0002242 ! nucleus pulposus +created_by: tmeehan +creation_date: 2011-03-02T02:12:23Z + +[Term] +id: CL:0002569 +name: mesenchymal stem cell of umbilical cord +namespace: cell +def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +is_a: CL:0000349 ! extraembryonic cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord +relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord +created_by: tmeehan +creation_date: 2011-03-01T09:55:12Z + [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue @@ -28831,6 +50685,31 @@ relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2011-03-01T09:57:17Z +[Term] +id: CL:0002571 +name: hepatic mesenchymal stem cell +namespace: cell +def: "A mesenchymal stem cell of liver." [GOC:tfm] +is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell +is_a: CL:0002195 ! hepatic stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0002107 ! liver +created_by: tmeehan +creation_date: 2011-03-01T09:58:51Z + +[Term] +id: CL:0002572 +name: vertebral mesenchymal stem cell +namespace: cell +def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] +is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell +is_a: CL:0001035 ! bone cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0002412 ! vertebra +relationship: part_of UBERON:0002412 ! vertebra +created_by: tmeehan +creation_date: 2011-03-01T10:40:27Z + [Term] id: CL:0002573 name: Schwann cell @@ -28838,6 +50717,7 @@ namespace: cell def: "A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function." [GOC:tfm] xref: BTO:0001220 xref: CALOHA:TS-0898 +xref: MESH:D012583 is_a: CL:0000125 ! glial cell intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000010 ! peripheral nervous system @@ -28845,6 +50725,58 @@ relationship: part_of UBERON:0000010 ! peripheral nervous system created_by: tmeehan creation_date: 2011-03-02T01:19:27Z +[Term] +id: CL:0002574 +name: stromal cell of pancreas +namespace: cell +def: "A stromal cell of the pancreas." [GOC:tfm] +is_a: CL:0000499 {is_inferred="true"} ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas +created_by: tmeehan +creation_date: 2011-03-02T02:40:41Z + +[Term] +id: CL:0002575 +name: central nervous system pericyte +namespace: cell +def: "A pericyte of the central nervous system." [GOC:tfm] +is_a: CL:0000669 {is_inferred="true"} ! pericyte cell +is_a: CL:0002319 ! neural cell +intersection_of: CL:0000669 ! pericyte cell +intersection_of: part_of UBERON:0001017 ! central nervous system +relationship: part_of UBERON:0001017 ! central nervous system +created_by: tmeehan +creation_date: 2011-03-02T02:54:18Z + +[Term] +id: CL:0002576 +name: perineural cell +namespace: cell +def: "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." [GO:tfm, http://en.wikipedia.org/wiki/Perineurium] +is_a: CL:0000186 {is_inferred="true"} ! myofibroblast cell +is_a: CL:0002319 ! neural cell +is_a: CL:0002320 ! connective tissue cell +intersection_of: CL:0000186 ! myofibroblast cell +intersection_of: part_of UBERON:0000121 ! perineurium +relationship: part_of UBERON:0000121 ! perineurium +created_by: tmeehan +creation_date: 2011-03-02T03:03:58Z + +[Term] +id: CL:0002577 +name: placental epithelial cell +namespace: cell +def: "An epithelial cell of the placenta." [GOC:tfm] +is_a: CL:0000066 ! epithelial cell +is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta +created_by: tmeehan +creation_date: 2011-03-02T03:21:30Z + [Term] id: CL:0002584 name: renal cortical epithelial cell @@ -28853,6 +50785,8 @@ def: "An epithelial cell of the kidney cortex." [GOC:tfm] xref: KUPO:0001016 is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell +intersection_of: CL:0002518 ! kidney epithelial cell +intersection_of: part_of UBERON:0001225 ! cortex of kidney [Term] id: CL:0002585 @@ -28867,6 +50801,23 @@ relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2011-03-06T03:28:27Z +[Term] +id: CL:0002586 +name: retinal pigment epithelial cell +namespace: cell +def: "An epithelial cell of the retinal pigmented epithelium." [GOC:tfm] +xref: BTO:0004910 +xref: FMA:75802 +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0000149 ! visual pigment cell +is_a: CL:0009004 ! retinal cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001782 ! pigmented layer of retina +relationship: has_part GO:0042470 ! melanosome +relationship: part_of UBERON:0001782 ! pigmented layer of retina +created_by: tmeehan +creation_date: 2011-03-06T03:37:09Z + [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature @@ -28905,6 +50856,55 @@ relationship: part_of UBERON:0002012 ! pulmonary artery created_by: tmeehan creation_date: 2011-03-06T05:01:28Z +[Term] +id: CL:0002592 +name: smooth muscle cell of the coronary artery +namespace: cell +def: "A smooth muscle cell of the coronary artery." [GOC:tfm] +is_a: CL:0002494 ! cardiocyte +is_a: CL:0019018 ! blood vessel smooth muscle cell +intersection_of: CL:0000359 ! vascular associated smooth muscle cell +intersection_of: part_of UBERON:0001621 ! coronary artery +relationship: part_of UBERON:0001621 ! coronary artery +created_by: tmeehan +creation_date: 2011-03-06T05:01:34Z + +[Term] +id: CL:0002593 +name: smooth muscle cell of the internal thoracic artery +namespace: cell +def: "A smooth muscle of the internal thoracic artery." [GOC:tfm] +is_a: CL:0002595 ! smooth muscle cell of the subclavian artery +intersection_of: CL:0000359 ! vascular associated smooth muscle cell +intersection_of: part_of UBERON:0002456 ! internal thoracic artery +relationship: part_of UBERON:0002456 ! internal thoracic artery +created_by: tmeehan +creation_date: 2011-03-06T05:01:41Z + +[Term] +id: CL:0002594 +name: smooth muscle cell of the umbilical artery +namespace: cell +def: "A smooth muscle cell of the umbilical artery." [GOC:tfm] +is_a: CL:0019018 ! blood vessel smooth muscle cell +intersection_of: CL:0000359 ! vascular associated smooth muscle cell +intersection_of: part_of UBERON:0001310 ! umbilical artery +relationship: part_of UBERON:0001310 ! umbilical artery +created_by: tmeehan +creation_date: 2011-03-06T05:01:48Z + +[Term] +id: CL:0002595 +name: smooth muscle cell of the subclavian artery +namespace: cell +def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] +is_a: CL:0019018 ! blood vessel smooth muscle cell +intersection_of: CL:0000359 ! vascular associated smooth muscle cell +intersection_of: part_of UBERON:0001533 ! subclavian artery +relationship: part_of UBERON:0001533 ! subclavian artery +created_by: tmeehan +creation_date: 2011-03-06T05:01:52Z + [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery @@ -28917,6 +50917,31 @@ relationship: part_of UBERON:0005396 ! carotid artery segment created_by: tmeehan creation_date: 2011-03-06T05:01:56Z +[Term] +id: CL:0002597 +name: smooth muscle cell of bladder +namespace: cell +def: "A smooth muscle cell of the bladder." [GC:tfm] +xref: KUPO:0001122 +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +is_a: CL:1001319 ! bladder cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001255 ! urinary bladder +created_by: tmeehan +creation_date: 2011-03-06T05:43:24Z + +[Term] +id: CL:0002598 +name: bronchial smooth muscle cell +namespace: cell +xref: BTO:0004402 +is_a: CL:0019019 ! tracheobronchial smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus +created_by: tmeehan +creation_date: 2011-03-06T05:46:39Z + [Term] id: CL:0002599 name: smooth muscle cell of the esophagus @@ -28929,10 +50954,93 @@ relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2011-03-06T05:48:17Z +[Term] +id: CL:0002600 +name: smooth muscle cell of trachea +namespace: cell +def: "A smooth muscle cell of the trachea." [GOC:tfm] +is_a: CL:0019019 ! tracheobronchial smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0003126 ! trachea +created_by: tmeehan +creation_date: 2011-03-06T05:50:28Z + +[Term] +id: CL:0002601 +name: uterine smooth muscle cell +namespace: cell +def: "A smooth muscle cell of the uterus." [GOC:tfm] +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0000995 ! uterus +relationship: part_of UBERON:0000995 ! uterus +created_by: tmeehan +creation_date: 2011-03-06T05:53:28Z + +[Term] +id: CL:0002602 +name: annulus pulposus cell +namespace: cell +synonym: "anulus pulposus cell" EXACT [] +is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell +intersection_of: CL:0002320 ! connective tissue cell +intersection_of: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis +relationship: part_of UBERON:0004715 ! annulus fibrosus disci intervertebralis +created_by: tmeehan +creation_date: 2011-03-06T06:50:53Z + +[Term] +id: CL:0002603 +name: astrocyte of the cerebellum +namespace: cell +def: "An astrocyte of the cerebellum." [GOC:tfm] +is_a: CL:0000127 {is_inferred="true"} ! astrocyte +is_a: CL:2000005 ! brain macroglial cell +intersection_of: CL:0000127 ! astrocyte +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum +created_by: tmeehan +creation_date: 2011-03-06T06:57:27Z + +[Term] +id: CL:0002604 +name: astrocyte of the hippocampus +namespace: cell +is_a: CL:0002605 ! astrocyte of the cerebral cortex +is_a: CL:1001580 ! hippocampus glial cell +intersection_of: CL:0000127 ! astrocyte +intersection_of: part_of UBERON:0001954 ! Ammon's horn +created_by: tmeehan +creation_date: 2011-03-06T06:57:33Z + +[Term] +id: CL:0002605 +name: astrocyte of the cerebral cortex +namespace: cell +def: "An astrocyte of the cerebral cortex." [GOC:tfm] +is_a: CL:0012000 ! astrocyte of the forebrain +is_a: CL:1001579 ! cerebral cortex glial cell +intersection_of: CL:0000127 ! astrocyte +intersection_of: part_of UBERON:0000956 ! cerebral cortex +created_by: tmeehan +creation_date: 2011-03-06T06:57:36Z + +[Term] +id: CL:0002606 +name: astrocyte of the spinal cord +namespace: cell +def: "An astrocyte of the spinal cord." [GOC:tfm] +is_a: CL:0000127 {is_inferred="true"} ! astrocyte +intersection_of: CL:0000127 ! astrocyte +intersection_of: part_of UBERON:0002240 ! spinal cord +relationship: part_of UBERON:0002240 ! spinal cord +created_by: tmeehan +creation_date: 2011-03-06T07:11:26Z + [Term] id: CL:0002607 name: migratory enteric neural crest cell -namespace: cell def: "A neural crest cell that gives rise to cells of the enteric nervous system." [GOC:tfm] is_a: CL:0000333 ! migratory neural crest cell created_by: tmeehan @@ -28943,27 +51051,17 @@ id: CL:0002608 name: hippocampal neuron namespace: cell def: "A neuron of the hippocampus." [GOC:tfm] -is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) +is_a: CL:0010012 ! cerebral cortex neuron +is_a: CL:0012001 ! neuron of the forebrain +intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) +intersection_of: part_of UBERON:0001954 ! Ammon's horn +relationship: part_of UBERON:0001954 ! Ammon's horn created_by: tmeehan creation_date: 2011-03-06T07:31:49Z -[Term] -id: CL:0002609 -name: obsolete neuron of cerebral cortex -namespace: cell -def: "OBSOLETE. A CNS neuron of the cerebral cortex." [GOC:tfm] -synonym: "cortical neuron" EXACT [] -xref: BTO:0004102 -xref: FMA:84104 -is_obsolete: true -replaced_by: CL:0010012 -created_by: tmeehan -creation_date: 2011-03-06T07:37:08Z - [Term] id: CL:0002610 name: raphe nuclei neuron -namespace: cell def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron @@ -28976,7 +51074,6 @@ creation_date: 2011-03-06T07:42:06Z [Term] id: CL:0002612 name: neuron of the ventral spinal cord -namespace: cell def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron @@ -28986,6 +51083,36 @@ relationship: RO:0002100 UBERON:0002257 ! has soma location ventral horn of spin created_by: tmeehan creation_date: 2011-03-06T07:46:03Z +[Term] +id: CL:0002615 +name: adipocyte of omentum tissue +namespace: cell +def: "A fat cell that is part of omentum tissue." [GOC:tfm] +synonym: "omental adipocyte" EXACT [] +synonym: "omental fat cell" EXACT [] +is_a: CL:0000136 {is_inferred="true"} ! fat cell +intersection_of: CL:0000136 ! fat cell +intersection_of: part_of UBERON:0003688 ! omentum +relationship: part_of UBERON:0003688 ! omentum +created_by: tmeehan +creation_date: 2011-03-14T10:17:00Z + +[Term] +id: CL:0002617 +name: adipocyte of breast +namespace: cell +def: "A fat cell that is part of the breast." [GOC:tfm] +comment: Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA] +synonym: "breast adipocyte" EXACT [] +synonym: "fat cell of breast" EXACT [] +xref: CALOHA:TS-2377 +is_a: CL:0000136 {is_inferred="true"} ! fat cell +intersection_of: CL:0000136 ! fat cell +intersection_of: part_of UBERON:0000310 ! breast +relationship: part_of UBERON:0000310 ! breast +created_by: tmeehan +creation_date: 2011-03-14T10:17:07Z + [Term] id: CL:0002620 name: skin fibroblast @@ -29000,6 +51127,42 @@ relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2011-03-14T12:31:49Z +[Term] +id: CL:0002621 +name: gingival epithelial cell +namespace: cell +is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001949 ! gingival epithelium +relationship: part_of UBERON:0001949 ! gingival epithelium +created_by: tmeehan +creation_date: 2011-03-14T12:46:28Z + +[Term] +id: CL:0002622 +name: prostate stromal cell +namespace: cell +def: "A stromal cell of the prostate." [GOC:tfm] +xref: BTO:0003972 +is_a: CL:0000499 {is_inferred="true"} ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland +created_by: tmeehan +creation_date: 2011-03-14T02:11:10Z + +[Term] +id: CL:0002623 +name: acinar cell of salivary gland +namespace: cell +def: "An acinar cell of salivary gland." [GOC:tfm] +is_a: CL:0000622 {is_inferred="true"} ! acinar cell +is_a: CL:1001596 ! salivary gland glandular cell +intersection_of: CL:0000622 ! acinar cell +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland +created_by: tmeehan +creation_date: 2011-03-14T02:22:22Z + [Term] id: CL:0002625 name: seminiferous tubule epithelial cell @@ -29007,9 +51170,23 @@ namespace: cell def: "A cell of the seminiferous tubule epithelium." [GOC:tfm] is_a: CL:0000068 ! duct epithelial cell is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis +relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium created_by: tmeehan creation_date: 2011-03-15T11:59:23Z +[Term] +id: CL:0002631 +name: epithelial cell of upper respiratory tract +namespace: cell +is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell +intersection_of: CL:0002368 ! respiratory epithelial cell +intersection_of: part_of UBERON:0001557 ! upper respiratory tract +relationship: part_of UBERON:0001557 ! upper respiratory tract +created_by: tmeehan +creation_date: 2011-06-21T12:28:55Z + [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract @@ -29024,7 +51201,6 @@ creation_date: 2011-06-21T12:29:31Z [Term] id: CL:0002633 name: respiratory basal cell -namespace: cell def: "A basal cell in the respiratory tract." [GOC:tfm, PMID:20699479] synonym: "airway basal cell" EXACT [] synonym: "airway basal stem cell" EXACT [] @@ -29033,10 +51209,34 @@ is_a: CL:0002368 ! respiratory epithelial cell created_by: tmeehan creation_date: 2011-06-21T03:11:10Z +[Term] +id: CL:0002634 +name: epithelial cell of anal column +namespace: cell +def: "An epithelial cell of the anal column." [GOC:tfm] +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0009882 ! anal column +relationship: part_of UBERON:0009882 ! anal column +created_by: tmeehan +creation_date: 2011-07-08T12:11:38Z + +[Term] +id: CL:0002637 +name: keratinized epithelial cell of the anal canal +namespace: cell +def: "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal." [GOC:tfm] +is_a: CL:0000237 ! keratinizing barrier epithelial cell +is_a: CL:0002634 ! epithelial cell of anal column +is_a: CL:0009066 ! stratified squamous epithelial cell of anal canal +intersection_of: CL:0000237 ! keratinizing barrier epithelial cell +intersection_of: part_of UBERON:0000159 ! anal canal +created_by: tmeehan +creation_date: 2011-07-08T02:08:40Z + [Term] id: CL:0002638 name: bronchioalveolar stem cell -namespace: cell def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc." [GOC:tfm, PMID:15960971] synonym: "basal epithelial cell of bronchioalveolar duct junction" EXACT [] synonym: "BASC" EXACT [] @@ -29045,6 +51245,19 @@ is_a: CL:1000351 ! basal cell of epithelium of respiratory bronchiole created_by: tmeehan creation_date: 2011-06-21T03:26:08Z +[Term] +id: CL:0002656 +name: glandular cell of endometrium +namespace: cell +def: "A glandular epithelial cell of the endometrium." [GOC:tfm] +xref: FMA:86489 +is_a: CL:1001591 ! oviduct glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001295 ! endometrium +relationship: part_of UBERON:0001295 ! endometrium +created_by: tmeehan +creation_date: 2011-07-08T03:54:08Z + [Term] id: CL:0002657 name: glandular cell of esophagus @@ -29066,6 +51279,8 @@ def: "A glandular epithelial cell of the large intestine." [GOC:tfm] xref: FMA:87194 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2011-07-08T04:03:01Z @@ -29086,7 +51301,6 @@ creation_date: 2011-07-11T01:20:35Z [Term] id: CL:0002663 name: myocardial endocrine cell of atrium -namespace: cell def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] xref: FMA:83389 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell @@ -29099,7 +51313,6 @@ creation_date: 2011-07-11T02:45:39Z [Term] id: CL:0002664 name: cardioblast -namespace: cell def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] @@ -29111,7 +51324,6 @@ creation_date: 2011-07-11T03:15:38Z [Term] id: CL:0002665 name: otic fibrocyte -namespace: cell def: "A fibrocyte of the cochlea that has specialized structural and molecular adaptions." [GOC:tfm, PMID:18353863] is_a: CL:0000135 ! fibrocyte created_by: tmeehan @@ -29120,7 +51332,6 @@ creation_date: 2011-07-11T03:35:01Z [Term] id: CL:0002666 name: type 2 otic fibrocyte -namespace: cell def: "An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type II otic fibrocyte" EXACT [] synonym: "type II spiral ligament fibrocyte" EXACT [MP:0004488] @@ -29131,7 +51342,6 @@ creation_date: 2011-07-11T03:40:40Z [Term] id: CL:0002668 name: type 4 otic fibrocyte -namespace: cell def: "An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall." [GOC:tfm, PMID:18353863] synonym: "type IV otic fibrocyte" EXACT [] synonym: "type IV spiral ligament fibrocyte" EXACT [MP:0004490] @@ -29142,7 +51352,6 @@ creation_date: 2011-07-11T03:40:46Z [Term] id: CL:0002669 name: type 3 otic fibrocyte -namespace: cell def: "An otic fibrocyte that lines the otic capsule." [GOC:tfm, PMID:18353863] synonym: "type III otic fibrocyte" EXACT [] synonym: "type III spiral ligament fibrocyte" EXACT [MP:0004489] @@ -29153,7 +51362,6 @@ creation_date: 2011-07-11T03:40:50Z [Term] id: CL:0002670 name: type 1 otic fibrocyte -namespace: cell def: "An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph." [GOC:tfm, PMID:18353863] synonym: "type I otic fibrocyte" EXACT [] synonym: "type I spiral ligament fibrocyte" EXACT [MP:0004487] @@ -29166,7 +51374,6 @@ id: CL:0002672 name: retinal progenitor cell namespace: cell def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000048 ! multi fate stem cell relationship: develops_from CL:0000133 ! neurectodermal cell created_by: tmeehan @@ -29195,11 +51402,26 @@ relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2011-08-22T09:24:15Z +[Term] +id: CL:0002680 +name: PP cell of intestine +namespace: cell +def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] +is_a: CL:0000696 {is_inferred="true"} ! PP cell +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: part_of UBERON:0000160 ! intestine +created_by: tmeehan +creation_date: 2011-09-27T11:59:01Z + [Term] id: CL:0002681 name: kidney cortical cell namespace: cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0001225 ! cortex of kidney +relationship: part_of UBERON:0001225 ! cortex of kidney created_by: terryh creation_date: 2011-10-25T03:49:41Z @@ -29225,13 +51447,14 @@ is_a: CL:0002518 ! kidney epithelial cell [Term] id: CL:0005010 name: renal intercalated cell -namespace: cell def: "A cuboidal epithelial cell of the kidney that regulates acid/base balance." [CL:CVS] +comment: Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells. {xref="PMID:25632105"} synonym: "intercalated cell" EXACT [] xref: FMA:86560 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:0002518 ! kidney epithelial cell +property_value: dc-contributor http://orcid.org/0000-0002-1773-2692 xsd:string [Term] id: CL:0005012 @@ -29247,7 +51470,6 @@ is_a: CL:0000067 ! ciliated epithelial cell [Term] id: CL:0005014 name: auditory epithelial supporting cell -namespace: cell def: "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells." [CL:CVS, GOC:tfm] synonym: "auditory epithelial support cell" EXACT [] is_a: CL:0000630 ! supporting cell @@ -29257,25 +51479,62 @@ is_a: CL:0002491 ! auditory epithelial cell [Term] id: CL:0005018 name: ghrelin secreting cell -namespace: cell def: "A cell that secretes ghrelin, the peptide hormone that stimulates hunger." [CL:curator] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0005019 name: pancreatic epsilon cell -namespace: cell def: "Ghrelin secreting cells found in the endocrine pancreas." [PMID:14970313] comment: In mammals the endocrine pancreas is called the Islets of Langerhans. synonym: "pancreatic E cell" EXACT [] is_a: CL:0005018 ! ghrelin secreting cell is_a: CL:0008024 ! pancreatic endocrine cell +[Term] +id: CL:0005020 +name: lymphangioblast +namespace: cell +def: "Lymphatic progenitor cells." [CL:CVS] +comment: Usually express Prox1, or prox1b. +is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell +intersection_of: CL:0000048 ! multi fate stem cell +intersection_of: adjacent_to UBERON:0004536 ! lymph vasculature +relationship: adjacent_to UBERON:0004536 ! lymph vasculature +created_by: Ceri +creation_date: 2012-01-12T04:44:34Z + +[Term] +id: CL:0005022 +name: vascular lymphangioblast +namespace: cell +def: "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells." [CL:CVS] +synonym: "parachordal lymphangioblast" NARROW [] +is_a: CL:0005020 {is_inferred="true"} ! lymphangioblast +intersection_of: CL:0005020 ! lymphangioblast +intersection_of: adjacent_to UBERON:0001638 ! vein +relationship: adjacent_to UBERON:0001638 ! vein +created_by: Ceri +creation_date: 2012-01-12T05:21:09Z + +[Term] +id: CL:0005024 +name: somatomotor neuron +def: "A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic." [ZFIN:CVS] +synonym: "somatic motor neuron" EXACT [] +is_a: CL:0000100 ! motor neuron +is_a: CL:0000108 ! cholinergic neuron +intersection_of: CL:0000100 ! motor neuron +intersection_of: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber +relationship: RO:0002120 CL:0008002 ! synapsed to skeletal muscle fiber + [Term] id: CL:0005026 name: hepatoblast def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants." [GOC:CVS, PMID:18356246, PMID:20483998] +def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] is_a: CL:0000048 ! multi fate stem cell +property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/800 xsd:string [Term] id: CL:0007000 @@ -29283,16 +51542,16 @@ name: preameloblast namespace: cell def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325] comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000055 ! non-terminally differentiated cell +relationship: adjacent_to UBERON:0001763 ! odontogenic papilla relationship: develops_from CL:0002077 ! ecto-epithelial cell +relationship: part_of UBERON:0005176 ! tooth enamel organ created_by: haendel creation_date: 2012-06-15T01:27:01Z [Term] id: CL:0007001 name: skeletogenic cell -namespace: cell def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) synonym: "scleroblast" EXACT [GO_REF:0000034] @@ -29300,12 +51559,33 @@ is_a: CL:0000003 ! native cell created_by: haendel creation_date: 2012-06-15T02:51:27Z +[Term] +id: CL:0007002 +name: precementoblast +namespace: cell +def: "Skeletogenic cell that has the potential to develop into a cementoblast." [GO_REF:0000034] +is_a: CL:0000055 ! non-terminally differentiated cell +relationship: part_of UBERON:0005176 ! tooth enamel organ +created_by: haendel +creation_date: 2012-06-15T04:37:13Z + +[Term] +id: CL:0007003 +name: preodontoblast +namespace: cell +def: "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." [GO_REF:0000034] +is_a: CL:0000055 ! non-terminally differentiated cell +is_a: CL:0011026 ! progenitor cell +relationship: develops_from CL:0000008 ! migratory cranial neural crest cell +relationship: part_of UBERON:0005176 ! tooth enamel organ +created_by: haendel +creation_date: 2012-06-15T05:15:11Z + [Term] id: CL:0007004 name: premigratory neural crest cell namespace: cell def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0011012 ! neural crest cell relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0002342 ! neural crest @@ -29331,13 +51611,13 @@ is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0011026 ! progenitor cell relationship: develops_from CL:0000222 ! mesodermal cell relationship: develops_from CL:0000333 ! migratory neural crest cell +relationship: part_of UBERON:0008883 ! osteoid created_by: haendel creation_date: 2012-06-27T10:57:21Z [Term] id: CL:0007011 name: enteric neuron -namespace: cell def: "Neuron that is part of the enteric nervous system." [CL:MAH] is_a: CL:0000029 ! neural crest derived neuron is_a: CL:0000107 ! autonomic neuron @@ -29361,6 +51641,7 @@ is_a: CL:0000988 ! hematopoietic cell id: CL:0008002 name: skeletal muscle fiber def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] +xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell @@ -29374,6 +51655,7 @@ relationship: develops_from CL:0000515 ! skeletal muscle myoblast id: CL:0008007 name: visceral muscle cell def: "A muscle cell that is part of some visceral muscle" [GOC:dos] +xref: FBbt:00005070 is_a: CL:0000187 ! muscle cell [Term] @@ -29433,6 +51715,9 @@ name: pancreatic endocrine cell namespace: cell def: "An endocrine cell that is part of the pancreas." [GOC:dos] is_a: CL:0000163 ! endocrine cell +intersection_of: CL:0000163 ! endocrine cell +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0008028 @@ -29452,6 +51737,17 @@ is_a: CL:0000540 ! neuron created_by: dos creation_date: 2017-07-12T11:11:06Z +[Term] +id: CL:0008031 +name: cortical interneuron +def: "An interneuron that has its soma located in the cerebral cortex." [] +synonym: "cerebral cortex interneuron" EXACT [] +is_a: CL:0000402 ! CNS interneuron +is_a: CL:0010012 ! cerebral cortex neuron +is_a: CL:0012001 ! neuron of the forebrain +intersection_of: CL:0000099 ! interneuron +intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex + [Term] id: CL:0008034 name: mural cell @@ -29487,10 +51783,13 @@ id: CL:0009000 name: sensory neuron of spinal nerve def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] synonym: "spinal sensory neuron" EXACT [] -is_a: CL:0000101 {is_inferred="true"} ! sensory neuron +is_a: CL:3000004 ! peripheral sensory neuron +intersection_of: CL:0000101 ! sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: part_of UBERON:0001780 ! spinal nerve +intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve relationship: part_of UBERON:0001780 ! spinal nerve +relationship: RO:0002100 UBERON:0001780 ! has soma location spinal nerve [Term] id: CL:0009001 @@ -29498,7 +51797,6 @@ name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] xref: GOC:pr xref: PMID:12021768 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0002371 ! somatic cell [Term] @@ -29512,6 +51810,461 @@ intersection_of: CL:0002319 ! neural cell intersection_of: part_of UBERON:0005388 ! photoreceptor array relationship: part_of UBERON:0005388 ! photoreceptor array +[Term] +id: CL:0009006 +name: enteroendocrine cell of small intestine +def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "small intestine enteroendocrine cell" EXACT [] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: part_of UBERON:0002108 ! small intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009018 +name: lymphocyte of large intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +synonym: "lamina propria lymphocyte of large intestine" EXACT [] +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine +relationship: part_of UBERON:0011189 ! lamina propria of large intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009019 +name: nephrogenic zone cell +def: "A kidney cortical cell that is part of the nephrogenic zone." [https://orcid.org/0000-0002-3163-0115, PMID:29449449] +subset: added_for_HCA +synonym: "cortical nephrogenic niche cell" EXACT [] +synonym: "cortical nephrogenic zone cell" EXACT [] +is_a: CL:0002681 ! kidney cortical cell +intersection_of: CL:0002681 ! kidney cortical cell +intersection_of: part_of UBERON:0009871 ! nephrogenic zone +relationship: part_of UBERON:0009871 ! nephrogenic zone +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009021 +name: stromal cell of lamina propria of large intestine +def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] +subset: location_grouping +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine +relationship: part_of UBERON:0011189 ! lamina propria of large intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009022 +name: stromal cell of lamina propria of small intestine +def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] +subset: location_grouping +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine +relationship: part_of UBERON:0001238 ! lamina propria of small intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009024 +name: mesothelial cell of small intestine +def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] +subset: location_grouping +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: part_of UBERON:0002108 ! small intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009025 +name: mesothelial cell of colon +def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "mesothelial cell of large intestine" BROAD [] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: part_of UBERON:0001155 ! colon +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009029 +name: mesothelial cell of appendix +def: "A mesothelial cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix mesothelial cell" EXACT [] +synonym: "mesothelial cell of appendix vermiformis" EXACT [] +synonym: "mesothelial cell of vermiform appendix" EXACT [] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:1000405 ! epithelial cell of appendix +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009030 +name: enteroendocrine cell of appendix +def: "An intestinal enteroendocrine cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix enteroendocrine cell" EXACT [] +synonym: "enteroendocrine cell of appendix vermiformis" EXACT [] +synonym: "enteroendocrine cell of vermiform appendix" EXACT [] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001585 ! appendix glandular cell +intersection_of: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009031 +name: T cell of appendix +def: "A T cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix T cell" EXACT [] +synonym: "T cell of appendix vermiformis" EXACT [] +synonym: "T cell of vermiform appendix" EXACT [] +is_a: CL:0000084 ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009032 +name: B cell of appendix +def: "A B cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix B cell" EXACT [] +synonym: "B cell of appendix vermiformis" EXACT [] +synonym: "B cell of vermiform appendix" EXACT [] +is_a: CL:0000236 ! B cell +intersection_of: CL:0000236 ! B cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009033 +name: plasma cell of appendix +def: "A plasma cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix plasma cell" EXACT [] +synonym: "plasma cell of appendix vermiformis" EXACT [] +synonym: "plasma cell of vermiform appendix" EXACT [] +is_a: CL:0000786 ! plasma cell +intersection_of: CL:0000786 ! plasma cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009034 +name: dendritic cell of appendix +def: "A dendritic cell that is located in a vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "appendix dendritic cell" EXACT [] +synonym: "dendritic cell of appendix vermiformis" EXACT [] +synonym: "dendritic cell of vermiform appendix" EXACT [] +is_a: CL:0000451 ! dendritic cell +intersection_of: CL:0000451 ! dendritic cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009035 +name: stromal cell of lamina propria of vermiform appendix +def: "A stromal cell found in the lamina propria of the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "stromal cell of appendix lamina propria" EXACT [] +synonym: "stromal cell of lamina propria of appendix vermiformis" EXACT [] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009036 +name: appendix macrophage +def: "A macrophage located in the vermiform appendix." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "macrophage of appendix" EXACT [] +synonym: "macrophage of appendix vermiformis" EXACT [] +synonym: "macrophage of vermiform appendix" EXACT [] +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009038 +name: colon macrophage +def: "A macrophage that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +synonym: "macrophage of colon" EXACT [] +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: part_of UBERON:0001155 ! colon +relationship: part_of UBERON:0001155 ! colon +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009039 +name: colon goblet cell +def: "A goblet cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "goblet cell of colon" EXACT [] +is_a: CL:1000320 ! large intestine goblet cell +is_a: CL:1001588 ! colon glandular cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001155 ! colon +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009040 +name: stromal cell of lamina propria of colon +def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "stromal cell of colon lamina propria" EXACT [] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0007177 ! lamina propria of mucosa of colon +relationship: part_of UBERON:0007177 ! lamina propria of mucosa of colon +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009042 +name: enteroendocrine cell of colon +def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "colon enteroendocrine cell" EXACT [] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001588 ! colon glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: part_of UBERON:0001155 ! colon +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009044 +name: lymphocyte of small intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +synonym: "gastrointestinal tract (lamina propria) lymphocyte of small intestine" EXACT [] +synonym: "gastrointestinal tract small intestine (lamina propria) leukocyte" BROAD [] +synonym: "lamina propria lymphocyte of small intestine" EXACT [] +synonym: "small intestine lamina propria leukocyte" BROAD [] +synonym: "small intestine lamina propria leukocyte (LPL)" BROAD [] +synonym: "small intestine lamina propria lymphocyte" EXACT [] +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine +relationship: part_of UBERON:0001238 ! lamina propria of small intestine +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009048 +name: anorectum macrophage +def: "A macrophage that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +synonym: "macrophage of anorectum" EXACT [] +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: part_of UBERON:8410050 ! anorectum +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009051 +name: T cell of anorectum +def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +is_a: CL:0000084 ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: part_of UBERON:8410050 ! anorectum +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009052 +name: smooth muscle cell of anorectum +def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "anorectum smooth muscle cell" EXACT [] +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: part_of UBERON:8410050 ! anorectum +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009053 +name: stromal cell of anorectum lamina propria +def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: part_of UBERON:8410050 ! anorectum +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009063 +name: enteroendocrine cell of anorectum +def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "anorectum enteroendocrine cell" EXACT [] +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: part_of UBERON:8410050 ! anorectum +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009066 +name: stratified squamous epithelial cell of anal canal +def: "A stratified squamous epithelial cell that is part of the anal canal." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +subset: location_grouping +synonym: "anal canal stratified squamous epithelial cell" EXACT [] +is_a: CL:0000240 ! stratified squamous epithelial cell +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000240 ! stratified squamous epithelial cell +intersection_of: part_of UBERON:0000159 ! anal canal +relationship: part_of UBERON:0000159 ! anal canal +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009084 +name: epithelial cell of endometrial gland +def: "An epithelial cell that is part of an endometrial gland." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "endometrial glandular epithelial cell" EXACT [] +xref: EFO:0010710 +is_a: CL:0000066 ! epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002451 ! endometrial gland +relationship: part_of UBERON:0002451 ! endometrial gland +property_value: http://purl.org/dc/elements/1.1/date 2021-11-30T16:13:30Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009089 +name: lung pericyte +def: "A pericyte cell that is part of a lung." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "lung pericyte cell" EXACT [] +synonym: "pulmonary pericyte" EXACT [] +xref: EFO:0010669 +is_a: CL:0000669 ! pericyte cell +intersection_of: CL:0000669 ! pericyte cell +intersection_of: part_of UBERON:0002048 ! lung +relationship: part_of UBERON:0002048 ! lung +property_value: http://purl.org/dc/elements/1.1/date 2021-12-03T17:13:33Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009091 +name: Leydig stem cell +def: "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells." [http://orcid.org/0000-0002-0819-0473, PMID:21181888] +synonym: "stem Leydig cell" EXACT [] +is_a: CL:0000034 ! stem cell +property_value: http://purl.org/dc/elements/1.1/date 2022-02-18T14:09:25Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009092 +name: endothelial cell of placenta +def: "An endothelial cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "placental endothelial cell" EXACT [] +xref: EFO:0010708 +is_a: CL:0000115 ! endothelial cell +is_a: CL:0002577 ! placental epithelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0001987 ! placenta +property_value: http://purl.org/dc/elements/1.1/date 2021-12-13T13:53:01Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009093 +name: smooth muscle cell of placenta +def: "A smooth muscle cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "placental smooth muscle cell" EXACT [] +xref: EFO:0010709 +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta +property_value: http://purl.org/dc/elements/1.1/date 2021-12-13T13:56:42Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009094 +name: endothelial cell of hepatic portal vein +def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] +subset: location_grouping +synonym: "portal endothelial cell" BROAD [] +xref: EFO:0010704 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0001639 ! hepatic portal vein +relationship: part_of UBERON:0001639 ! hepatic portal vein +property_value: http://purl.org/dc/elements/1.1/date 2021-12-13T14:01:05Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009095 +name: endothelial cell of uterus +def: "An endothelial cell that is part of a uterus." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "uterine endothelial cell" EXACT [] +xref: EFO:0010711 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0000995 ! uterus +relationship: part_of UBERON:0000995 ! uterus +property_value: http://purl.org/dc/elements/1.1/date 2021-12-13T14:39:25Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009097 +name: embryonic skeletal muscle fiber +def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] +is_a: CL:0008002 ! skeletal muscle fiber +intersection_of: CL:0008002 ! skeletal muscle fiber +intersection_of: existence_starts_and_ends_during UBERON:0000068 ! embryo stage +relationship: existence_starts_and_ends_during UBERON:0000068 ! embryo stage +property_value: http://purl.org/dc/elements/1.1/date 2022-02-21T15:39:10Z xsd:dateTime +created_by: http://orcid.org/0000-0002-2825-0621 + +[Term] +id: CL:0009100 +name: hepatic portal fibroblast +def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] +synonym: "portal fibroblast" BROAD [] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0001279 ! portal triad +relationship: dc-contributor http://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001279 ! portal triad +property_value: http://purl.org/dc/elements/1.1/date 2022-03-17T12:00:44Z xsd:dateTime + [Term] id: CL:0010001 name: stromal cell of bone marrow @@ -29523,13 +52276,28 @@ intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm +[Term] +id: CL:0010002 +name: epithelial cell of umbilical artery +def: "An epithelial cell that is part_of a umbilical artery." [] +synonym: "umbilical artery epithelial cell" EXACT [] +is_a: CL:0000066 ! epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001310 ! umbilical artery +relationship: part_of UBERON:0001310 ! umbilical artery +created_by: GOC:cjm + [Term] id: CL:0010003 name: epithelial cell of alveolus of lung def: "An epithelial cell that is part_of a alveolus of lung." [] comment: May be merged with pneumocyte in future synonym: "alveolus of lung epithelial cell" EXACT [] +xref: MESH:D056809 is_a: CL:0000082 ! epithelial cell of lung +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002299 ! alveolus of lung +relationship: part_of UBERON:0002299 ! alveolus of lung created_by: GOC:cjm [Term] @@ -29543,6 +52311,16 @@ intersection_of: CL:0000842 ! mononuclear cell intersection_of: part_of UBERON:0002371 ! bone marrow created_by: GOC:cjm +[Term] +id: CL:0010005 +name: atrioventricular bundle cell +def: "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] +synonym: "AV bundle cell" EXACT [] +is_a: CL:0010007 ! His-Purkinje system cell +intersection_of: CL:0000003 ! native cell +intersection_of: part_of UBERON:0002353 ! bundle of His +relationship: part_of UBERON:0002353 ! bundle of His + [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell @@ -29554,7 +52332,6 @@ intersection_of: part_of UBERON:0000948 ! heart [Term] id: CL:0010007 name: His-Purkinje system cell -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0004146 ! His-Purkinje system @@ -29578,12 +52355,23 @@ intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye +[Term] +id: CL:0010011 +name: cerebral cortex GABAergic interneuron +def: "A GABAergic interneuron whose soma is located in the cerebral cortex." [GOC:dos] +is_a: CL:0008031 ! cortical interneuron +is_a: CL:0011005 ! GABAergic interneuron +intersection_of: CL:0011005 ! GABAergic interneuron +intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex + [Term] id: CL:0010012 name: cerebral cortex neuron namespace: cell +alt_id: CL:0002609 def: "A CNS neuron of the cerebral cortex." [GOC:tfm] synonym: "cortical neuron" EXACT [] +synonym: "neuron of cerebral cortex" EXACT [] xref: BTO:0004102 xref: FMA:84104 is_a: CL:2000029 ! central nervous system neuron @@ -29591,11 +52379,13 @@ intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex relationship: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-7258-9596 +property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/1359 xsd:string [Term] id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] +xref: MESH:D015053 is_a: CL:0000003 ! native cell property_value: seeAlso https://github.com/obophenotype/cell-ontology/issues/786 @@ -29612,6 +52402,7 @@ relationship: part_of UBERON:0000948 ! heart id: CL:0010021 name: cardiac myoblast namespace: cell +xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: develops_into CL:0000746 ! cardiac muscle cell @@ -29620,11 +52411,17 @@ relationship: develops_into CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron +def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] +comment: This term is used in 3 GO terms that were created as part of the heart development focus project. is_a: CL:0000540 ! neuron is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000540 ! neuron +intersection_of: CL:0000540 ! neuron intersection_of: part_of UBERON:0000948 ! heart +intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart relationship: part_of UBERON:0000948 ! heart +relationship: RO:0002100 UBERON:0000948 ! has soma location heart +property_value: seeAlso https://github.com/obophenotype/cell-ontology/pull/1488 xsd:string [Term] id: CL:0011001 @@ -29662,6 +52459,8 @@ comment: The formal and textual definitions of this term will need to be altered synonym: "GABAergic inhibitory interneuron" EXACT [] is_a: CL:0000498 ! inhibitory interneuron is_a: CL:0000617 ! GABAergic neuron +intersection_of: CL:0000099 ! interneuron +intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission [Term] id: CL:0011007 @@ -29683,6 +52482,27 @@ def: "A cell of the neural crest. Neural crest cells are multipotent. Premigrato is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) +[Term] +id: CL:0011013 +name: motile sperm cell +def: "A sperm cell that is cabaple of motion (motility)." [PMID:30612620] +is_a: CL:0000019 ! sperm +is_a: CL:0000219 ! motile cell +intersection_of: CL:0000019 ! sperm +intersection_of: capable_of GO:0097722 ! sperm motility +relationship: capable_of GO:0097722 ! sperm motility +created_by: http://orcid.org/0000-0001-5208-3432 + +[Term] +id: CL:0011016 +name: flagellated sperm cell +def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." [https://www.lexico.com/en/definition/flagellum, PMID:30612620] +is_a: CL:0011013 ! motile sperm cell +intersection_of: CL:0011013 ! motile sperm cell +intersection_of: capable_of GO:0030317 ! flagellated sperm motility +relationship: capable_of GO:0030317 ! flagellated sperm motility +created_by: http://orcid.org/0000-0001-5208-3432 + [Term] id: CL:0011019 name: mesothelial cell of epicardium @@ -29718,7 +52538,6 @@ created_by: http://orcid.org/0000-0001-5208-3432 id: CL:0011026 name: progenitor cell def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell intersection_of: develops_from CL:0000034 ! stem cell @@ -29748,17 +52567,60 @@ intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: part_of UBERON:0002067 ! dermis created_by: http://orcid.org/0000-0001-5208-3432 +[Term] +id: CL:0011101 +name: chorionic trophoblast cell +def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV] +is_a: CL:0000351 ! trophoblast cell +intersection_of: CL:0000351 ! trophoblast cell +intersection_of: part_of UBERON:0003124 ! chorion membrane +relationship: part_of UBERON:0003124 ! chorion membrane + +[Term] +id: CL:0011108 +name: colon epithelial cell +def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] +synonym: "colonic epithelial cell" EXACT [] +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001155 ! colon +relationship: part_of UBERON:0000397 ! colonic epithelium + +[Term] +id: CL:0011111 +name: gonadotropin releasing neuron +def: "Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction." [GOC:NV, PMID:21828096] +synonym: "GnRH neuron" EXACT [] +synonym: "GnRH-secreting neuron" EXACT [] +is_a: CL:0000163 ! endocrine cell +is_a: CL:0000381 ! neurosecretory neuron +intersection_of: CL:0000540 ! neuron +intersection_of: capable_of GO:0032274 ! gonadotropin secretion +relationship: capable_of GO:0032274 ! gonadotropin secretion + [Term] id: CL:0011115 name: precursor cell def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. -is_a: BFO:0000040 ! material entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: capable_of GO:0030154 ! cell differentiation relationship: capable_of GO:0030154 ! cell differentiation +[Term] +id: CL:0012000 +name: astrocyte of the forebrain +namespace: cell +def: "An astrocyte of the forebrain." [] +synonym: "forebrain astrocyte" EXACT [] +is_a: CL:0000127 {is_inferred="true"} ! astrocyte +is_a: CL:2000005 ! brain macroglial cell +intersection_of: CL:0000127 ! astrocyte +intersection_of: part_of UBERON:0001890 ! forebrain +relationship: part_of UBERON:0001890 ! forebrain +created_by: tberardini + [Term] id: CL:0012001 name: neuron of the forebrain @@ -29772,12 +52634,23 @@ intersection_of: RO:0002100 UBERON:0001890 ! has soma location forebrain relationship: RO:0002100 UBERON:0001890 ! has soma location forebrain created_by: tberardini +[Term] +id: CL:0013000 +name: forebrain radial glial cell +is_a: CL:0000681 ! radial glial cell +intersection_of: CL:0000681 ! radial glial cell +intersection_of: part_of UBERON:0001890 ! forebrain +relationship: part_of UBERON:0001890 ! forebrain + [Term] id: CL:0017500 name: neutrophillic cytoplasm namespace: cell def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: GO:0099568 ! cytoplasmic region +intersection_of: GO:0005737 ! cytoplasm +intersection_of: bearer_of PATO:0070046 ! neutrophillic +relationship: bearer_of PATO:0070046 ! neutrophillic created_by: tmeehan creation_date: 2010-05-25T01:36:34Z @@ -29788,6 +52661,9 @@ namespace: cell def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] synonym: "eosinophilic" NARROW [] is_a: GO:0099568 ! cytoplasmic region +intersection_of: GO:0005737 ! cytoplasm +intersection_of: bearer_of PATO:0002418 ! acidophilic +relationship: bearer_of PATO:0002418 ! acidophilic created_by: tmeehan creation_date: 2009-12-22T04:23:25Z @@ -29809,6 +52685,9 @@ name: polychromatophilic cytoplasm namespace: cell def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0099568 ! cytoplasmic region +intersection_of: GO:0005737 ! cytoplasm +intersection_of: bearer_of PATO:0070047 ! polychromatophilic +relationship: bearer_of PATO:0070047 ! polychromatophilic created_by: tmeehan creation_date: 2009-12-28T04:25:23Z @@ -29824,6 +52703,66 @@ relationship: bearer_of PATO:0000586 ! increased size created_by: tmeehan creation_date: 2009-12-23T10:53:24Z +[Term] +id: CL:0017508 +name: cartwheel heterochromatin +namespace: cell +def: "Heterochromatin that is arranged in a carthwheel pattern." [GOC:tfm] +is_a: GO:0000792 ! heterochromatin +created_by: tmeehan +creation_date: 2009-12-28T04:28:35Z + +[Term] +id: CL:0019001 +name: tracheobronchial serous cell +def: "Any serous secreting cell that is part of the tracheobronchial epithelium." [] +subset: added_for_HCA +synonym: "serous cell of tracheobronchial tree" EXACT [] +is_a: CL:0000313 ! serous secreting cell +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree +relationship: part_of UBERON:0007196 ! tracheobronchial tree +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-05-07T16:03:27Z xsd:dateTime + +[Term] +id: CL:0019002 +name: tracheobronchial chondrocyte +def: "Any chondrocyte that is part of the tracheobronchial tree." [] +subset: added_for_HCA +synonym: "chondrocyte of tracheobronchial tree" EXACT [] +is_a: CL:0000138 ! chondrocyte +intersection_of: CL:0000138 ! chondrocyte +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree +relationship: part_of UBERON:0007196 ! tracheobronchial tree +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-05-07T17:29:51Z xsd:dateTime + +[Term] +id: CL:0019003 +name: tracheobronchial goblet cell +def: "Any goblet cell that is part of the tracheobronchial epithelium." [] +subset: added_for_HCA +synonym: "goblet cell of tracheobronchial tree" EXACT [] +is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +is_a: CL:0002370 ! respiratory goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-05-07T18:14:52Z xsd:dateTime + +[Term] +id: CL:0019017 +name: lymphatic vessel smooth muscle cell +def: "A smooth muscle cell that is part of any lymphatic vessel." [PMID:15109561] +synonym: "smooth muscle cell of lymphatic vessel" EXACT [] +is_a: CL:0000359 ! vascular associated smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001473 ! lymphatic vessel +relationship: part_of UBERON:0001473 ! lymphatic vessel +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-07-21T12:29:51Z xsd:dateTime + [Term] id: CL:0019018 name: blood vessel smooth muscle cell @@ -29836,6 +52775,58 @@ relationship: part_of UBERON:0001981 ! blood vessel property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/elements/1.1/date 2020-07-21T12:42:48Z xsd:dateTime +[Term] +id: CL:0019019 +name: tracheobronchial smooth muscle cell +def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] +synonym: "smooth muscle cell of tracheobronchial tree" EXACT [] +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree +relationship: part_of UBERON:0007196 ! tracheobronchial tree +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-07-21T12:50:22Z xsd:dateTime + +[Term] +id: CL:0019020 +name: extrahepatic cholangiocyte +def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] +synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296] +is_a: CL:1000488 ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: part_of UBERON:0004822 ! extrahepatic bile duct epithelium +relationship: part_of UBERON:0004822 ! extrahepatic bile duct epithelium +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-09-03T12:24:24Z xsd:dateTime + +[Term] +id: CL:0019021 +name: endothelial cell of periportal hepatic sinusoid +def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] +synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] +synonym: "periportal LSEC" EXACT [PMID:28287163] +xref: EFO:0010705 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: adjacent_to UBERON:0001279 ! portal triad +relationship: adjacent_to UBERON:0001279 ! portal triad +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-09-09T13:56:47Z xsd:dateTime + +[Term] +id: CL:0019022 +name: endothelial cell of pericentral hepatic sinusoid +def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] +synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985] +synonym: "pericentral LSEC" EXACT [PMID:28287163] +xref: EFO:0010706 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: adjacent_to UBERON:0006841 ! central vein of liver +relationship: adjacent_to UBERON:0006841 ! central vein of liver +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X +property_value: http://purl.org/dc/elements/1.1/date 2020-09-10T12:38:29Z xsd:dateTime + [Term] id: CL:0019031 name: intestine goblet cell @@ -29843,6 +52834,8 @@ def: "Goblet cells reside throughout the length of the small and large intestine synonym: "intestinal goblet cell" EXACT [PMID:1996606] is_a: CL:0000160 ! goblet cell is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001277 ! intestinal epithelium property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0003-2034-601X property_value: http://purl.org/dc/elements/1.1/date 2020-10-14T14:59:07Z xsd:dateTime @@ -29855,16 +52848,49 @@ intersection_of: CL:0000031 ! neuroblast (sensu Vertebrata) intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain +[Term] +id: CL:1000073 +name: spinal cord radial glial cell +is_a: CL:0000681 ! radial glial cell +intersection_of: CL:0000681 ! radial glial cell +intersection_of: part_of UBERON:0002240 ! spinal cord +relationship: part_of UBERON:0002240 ! spinal cord + [Term] id: CL:1000082 name: stretch receptor cell -namespace: cell is_a: CL:0000006 ! neuronal receptor cell +[Term] +id: CL:1000090 +name: pronephric nephron tubule epithelial cell +is_a: CL:1000449 ! epithelial cell of nephron +is_a: CL:1000507 ! kidney tubule cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule +relationship: part_of UBERON:0005310 ! pronephric nephron tubule + +[Term] +id: CL:1000123 +name: metanephric nephron tubule epithelial cell +is_a: CL:1000449 ! epithelial cell of nephron +is_a: CL:1000507 ! kidney tubule cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule +relationship: part_of UBERON:0005146 ! metanephric nephron tubule + +[Term] +id: CL:1000143 +name: lung goblet cell +is_a: CL:0000082 ! epithelial cell of lung +is_a: CL:0002370 ! respiratory goblet cell +is_a: CL:1000272 ! lung secretory cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002048 ! lung + [Term] id: CL:1000191 name: pillar cell -namespace: cell def: "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti." [GOC:tfm, PMID:12417662] synonym: "cochlear pillar cell" RELATED [] synonym: "pillar cell of cochlea" EXACT [] @@ -29893,7 +52919,6 @@ intersection_of: part_of UBERON:0002048 ! lung [Term] id: CL:1000271 name: lung ciliated cell -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002048 ! lung @@ -29902,12 +52927,176 @@ relationship: part_of UBERON:0002048 ! lung [Term] id: CL:1000272 name: lung secretory cell -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung +[Term] +id: CL:1000274 +name: trophectodermal cell +namespace: cell +synonym: "trophectoderm cell" EXACT [] +is_a: CL:0000349 ! extraembryonic cell + +[Term] +id: CL:1000275 +name: smooth muscle cell of small intestine +namespace: cell +def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] +synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050] +xref: FMA:15050 +is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0002108 ! small intestine + +[Term] +id: CL:1000276 +name: smooth muscle fiber of duodenum +namespace: cell +def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] +synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058] +xref: FMA:15058 +is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine +intersection_of: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0002114 ! duodenum + +[Term] +id: CL:1000277 +name: smooth muscle fiber of jejunum +namespace: cell +def: "A smooth muscle cell that is part of the jejunum." [GOC:tfm] +synonym: "non-striated muscle fiber of jejunum" EXACT [FMA:15062] +xref: FMA:15062 +is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine +intersection_of: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: part_of UBERON:0002115 ! jejunum +relationship: part_of UBERON:0002115 ! jejunum + +[Term] +id: CL:1000278 +name: smooth muscle fiber of ileum +namespace: cell +def: "A smooth muscle cell that is part of the ileum." [GOC:tfm] +synonym: "non-striated muscle fiber of ileum" EXACT [FMA:15066] +xref: FMA:15066 +is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine +intersection_of: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: part_of UBERON:0002116 ! ileum +relationship: part_of UBERON:0002116 ! ileum + +[Term] +id: CL:1000279 +name: smooth muscle cell of large intestine +namespace: cell +def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] +synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653] +xref: FMA:15653 +is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: part_of UBERON:0000059 ! large intestine +relationship: part_of UBERON:0000059 ! large intestine + +[Term] +id: CL:1000280 +name: smooth muscle cell of colon +namespace: cell +def: "A smooth muscle cell that is part of the colon." [GOC:tfm] +synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663] +xref: FMA:15663 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: part_of UBERON:0001155 ! colon +relationship: part_of UBERON:0001155 ! colon + +[Term] +id: CL:1000281 +name: smooth muscle cell of cecum +namespace: cell +def: "A smooth muscle cell that is part of the cecum." [GOC:tfm] +synonym: "non-striated muscle fiber of cecum" EXACT [FMA:15681] +synonym: "smooth muscle fiber of cecum" EXACT [] +xref: FMA:15681 +is_a: CL:1000280 ! smooth muscle cell of colon +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001153 ! caecum +relationship: part_of UBERON:0001153 ! caecum + +[Term] +id: CL:1000282 +name: smooth muscle fiber of ascending colon +namespace: cell +def: "A smooth muscle cell that is part of the ascending colon." [GOC:tfm] +synonym: "non-striated muscle fiber of ascending colon" EXACT [FMA:17518] +xref: FMA:17518 +is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: part_of UBERON:0001156 ! ascending colon +relationship: part_of UBERON:0001156 ! ascending colon + +[Term] +id: CL:1000283 +name: smooth muscle fiber of transverse colon +namespace: cell +def: "A smooth muscle cell that is part of the transverse colon." [GOC:tfm] +synonym: "non-striated muscle fiber of transverse colon" EXACT [FMA:17519] +xref: FMA:17519 +is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: part_of UBERON:0001157 ! transverse colon +relationship: part_of UBERON:0001157 ! transverse colon + +[Term] +id: CL:1000284 +name: smooth muscle fiber of descending colon +namespace: cell +def: "A smooth muscle cell that is part of the descending colon." [GOC:tfm] +synonym: "non-striated muscle fiber of descending colon" EXACT [FMA:17520] +xref: FMA:17520 +is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: part_of UBERON:0001158 ! descending colon +relationship: part_of UBERON:0001158 ! descending colon + +[Term] +id: CL:1000285 +name: smooth muscle cell of sigmoid colon +namespace: cell +def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] +synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521] +xref: FMA:17521 +is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: part_of UBERON:0001159 ! sigmoid colon +relationship: part_of UBERON:0001159 ! sigmoid colon + +[Term] +id: CL:1000286 +name: smooth muscle cell of rectum +namespace: cell +def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] +synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522] +synonym: "smooth muscle fiber of rectum" EXACT [] +xref: FMA:17522 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0001052 ! rectum +relationship: part_of UBERON:0001052 ! rectum + +[Term] +id: CL:1000296 +name: epithelial cell of urethra +namespace: cell +def: "An epithelial cell that is part of the urethra." [GOC:tfm] +xref: FMA:256165 +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 ! somatic cell +is_a: CL:1001320 ! urethra cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0000057 ! urethra + [Term] id: CL:1000298 name: mesothelial cell of dura mater @@ -29994,6 +53183,43 @@ intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle +[Term] +id: CL:1000312 +name: bronchial goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of bronchus." [GOC:tfm] +synonym: "goblet cell of epithelium of bronchus" EXACT [FMA:263032] +xref: FMA:263032 +is_a: CL:0002328 ! bronchial epithelial cell +is_a: CL:0019003 ! tracheobronchial goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002185 ! bronchus + +[Term] +id: CL:1000313 +name: gastric goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of stomach." [GOC:tfm] +synonym: "goblet cell of epithelium of stomach" EXACT [FMA:263035] +xref: FMA:263035 +is_a: CL:0000160 ! goblet cell +is_a: CL:0002180 ! mucous cell of stomach +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0000945 ! stomach +relationship: part_of UBERON:0001276 ! epithelium of stomach + +[Term] +id: CL:1000314 +name: gastric cardiac gland goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of gastric cardiac gland." [GOC:tfm] +synonym: "goblet cell of epithelium of gastric cardiac gland" EXACT [] +xref: FMA:263038 +is_a: CL:0000152 ! exocrine cell +is_a: CL:1000313 ! gastric goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0008859 ! cardiac gastric gland + [Term] id: CL:1000317 name: intestinal villus goblet cell @@ -30002,6 +53228,9 @@ def: "A goblet cell that is part of the epithelium of intestinal villus." [GOC:t synonym: "goblet cell of epithelium of intestinal villus" EXACT [] xref: FMA:263046 is_a: CL:1000495 ! small intestine goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001213 ! intestinal villus +relationship: part_of UBERON:0013636 ! epithelium of intestinal villus [Term] id: CL:1000320 @@ -30012,6 +53241,35 @@ synonym: "goblet cell of epithelium of large intestine" EXACT [] xref: FMA:263054 is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:0019031 ! intestine goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0000059 ! large intestine +relationship: part_of UBERON:0001278 ! epithelium of large intestine + +[Term] +id: CL:1000322 +name: pancreatic goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of pancreatic duct." [GOC:tfm] +synonym: "goblet cell of epithelium of pancreatic duct" EXACT [FMA:263058] +xref: FMA:263058 +is_a: CL:0000069 ! branched duct epithelial cell +is_a: CL:0000160 ! goblet cell +is_a: CL:1001599 ! pancreas exocrine glandular cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0009970 ! epithelium of pancreatic duct + +[Term] +id: CL:1000323 +name: pyloric gastric gland goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of pyloric gland." [GOC:tfm] +synonym: "goblet cell of epithelium of pyloric gland" EXACT [] +xref: FMA:263061 +is_a: CL:0000152 ! exocrine cell +is_a: CL:1000313 ! gastric goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0008861 ! pyloric gastric gland [Term] id: CL:1000324 @@ -30022,6 +53280,8 @@ synonym: "goblet cell of epithelium proper of duodenum" EXACT [] xref: FMA:263063 is_a: CL:1000317 ! intestinal villus goblet cell is_a: CL:1001589 ! duodenum glandular cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002114 ! duodenum [Term] id: CL:1000325 @@ -30031,6 +53291,8 @@ def: "A goblet cell that is part of the epithelium proper of jejunum." [GOC:tfm] synonym: "goblet cell of epithelium proper of jejunum" EXACT [] xref: FMA:263065 is_a: CL:1000317 ! intestinal villus goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002115 ! jejunum [Term] id: CL:1000326 @@ -30040,11 +53302,82 @@ def: "A goblet cell that is part of the epithelium proper of ileum." [GOC:tfm] synonym: "goblet cell of epithelium proper of ileum" EXACT [] xref: FMA:263067 is_a: CL:1000317 ! intestinal villus goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002116 ! ileum + +[Term] +id: CL:1000327 +name: appendix goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium proper of appendix." [GOC:tfm] +synonym: "goblet cell of epithelium proper of appendix" EXACT [] +xref: FMA:263069 +is_a: CL:1000320 ! large intestine goblet cell +is_a: CL:1001585 ! appendix glandular cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: CL:1000329 +name: tracheal goblet cell +namespace: cell +def: "A goblet cell that is part of the epithelium of trachea." [GOC:tfm] +synonym: "goblet cell of epithelium of trachea" EXACT [FMA:263075] +xref: FMA:263075 +is_a: CL:0000307 ! tracheal epithelial cell +is_a: CL:0019003 ! tracheobronchial goblet cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0001901 ! epithelium of trachea + +[Term] +id: CL:1000330 +name: serous cell of epithelium of trachea +namespace: cell +def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] +xref: FMA:263078 +is_a: CL:0019001 ! tracheobronchial serous cell +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: part_of UBERON:0001901 ! epithelium of trachea +relationship: part_of UBERON:0001901 ! epithelium of trachea + +[Term] +id: CL:1000331 +name: serous cell of epithelium of bronchus +namespace: cell +def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] +xref: FMA:263080 +is_a: CL:0019001 ! tracheobronchial serous cell +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: part_of UBERON:0002031 ! epithelium of bronchus +relationship: part_of UBERON:0002031 ! epithelium of bronchus + +[Term] +id: CL:1000332 +name: serous cell of epithelium of terminal bronchiole +namespace: cell +def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] +xref: FMA:263082 +is_a: CL:1000333 ! serous cell of epithelium of lobular bronchiole +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: part_of UBERON:0001958 ! terminal bronchiole epithelium +relationship: part_of UBERON:0001958 ! terminal bronchiole epithelium + +[Term] +id: CL:1000333 +name: serous cell of epithelium of lobular bronchiole +namespace: cell +def: "A serous secreting cell that is part of the epithelium of bronchiole." [GOC:tfm] +xref: FMA:263084 +is_a: CL:1000272 ! lung secretory cell +is_a: CL:1000331 ! serous cell of epithelium of bronchus +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole +relationship: part_of UBERON:0002051 ! epithelium of bronchiole [Term] id: CL:1000349 name: basal cell of epithelium of bronchus -namespace: cell alt_id: CL:0002331 def: "A basal cell found in the bronchus epithelium." [GOC:tfm] synonym: "basal cell of bronchus" EXACT [] @@ -30056,7 +53389,6 @@ is_a: CL:0002633 ! respiratory basal cell [Term] id: CL:1000350 name: basal cell of epithelium of terminal bronchiole -namespace: cell def: "A basal cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] xref: FMA:263122 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole @@ -30064,7 +53396,6 @@ is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole [Term] id: CL:1000351 name: basal cell of epithelium of respiratory bronchiole -namespace: cell def: "A basal cell that is part of the epithelium of respiratory bronchiole." [GOC:tfm] xref: FMA:263124 is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole @@ -30072,7 +53403,6 @@ is_a: CL:1000352 ! basal cell of epithelium of lobular bronchiole [Term] id: CL:1000352 name: basal cell of epithelium of lobular bronchiole -namespace: cell def: "A basal cell that is part of the epithelium of bronchiole." [GOC:tfm] xref: FMA:263126 is_a: CL:0000082 ! epithelial cell of lung @@ -30081,7 +53411,6 @@ is_a: CL:1000349 ! basal cell of epithelium of bronchus [Term] id: CL:1000361 name: transitional myocyte of interatrial septum -namespace: cell def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] xref: FMA:263152 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte @@ -30093,7 +53422,6 @@ relationship: part_of UBERON:0002085 ! interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum -namespace: cell def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] xref: FMA:263154 is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte @@ -30114,6 +53442,47 @@ intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum +[Term] +id: CL:1000391 +name: melanocyte of eyelid +namespace: cell +def: "A melanocyte that is part of the eyelid." [GOC:tfm] +synonym: "eyelid melanocyte" EXACT [FMA:59175] +synonym: "sebaceous gland of wolff" EXACT [FMA:59175] +xref: FMA:59175 +is_a: CL:0000148 {is_inferred="true"} ! melanocyte +intersection_of: CL:0000148 ! melanocyte +intersection_of: part_of UBERON:0001711 ! eyelid +relationship: part_of UBERON:0001711 ! eyelid + +[Term] +id: CL:1000398 +name: endothelial cell of hepatic sinusoid +namespace: cell +def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] +synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911] +synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985] +synonym: "LSEC" EXACT [PMID:30348985] +xref: BTO:000125 +xref: FMA:62911 +is_a: CL:0002262 ! endothelial cell of sinusoid +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0001281 ! hepatic sinusoid +relationship: part_of UBERON:0001281 ! hepatic sinusoid + +[Term] +id: CL:1000405 +name: epithelial cell of appendix +namespace: cell +def: "An epithelial cell that is part of the appendix." [GOC:tfm] +synonym: "columnar epitheliocyte of appendix" EXACT [FMA:63602] +synonym: "epithelial cell of vermiform appendix" EXACT [FMA:63602] +xref: FMA:63602 +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + [Term] id: CL:1000409 name: myocyte of sinoatrial node @@ -30186,6 +53555,42 @@ intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule +[Term] +id: CL:1000415 +name: epithelial cell of gall bladder +namespace: cell +def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] +xref: FMA:67780 +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder + +[Term] +id: CL:1000417 +name: myoepithelial cell of sweat gland +namespace: cell +def: "A myoepithelial cell that is part of the sweat gland." [GOC:tfm] +xref: FMA:67801 +is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell +is_a: CL:1000448 ! epithelial cell of sweat gland +intersection_of: CL:0000185 ! myoepithelial cell +intersection_of: part_of UBERON:0001820 ! sweat gland + +[Term] +id: CL:1000418 +name: myoepithelial cell of lactiferous alveolus +namespace: cell +def: "A myoepithelial cell that is part of the mammary gland alveolus." [GOC:tfm] +synonym: "basal cell of alveolus of lactiferous gland" EXACT [FMA:67802] +synonym: "myoepithelial cell of mammary alveolus" EXACT [FMA:67802] +xref: FMA:67802 +is_a: CL:0002324 ! myoepithelial cell of mammary gland +intersection_of: CL:0000185 ! myoepithelial cell +intersection_of: part_of UBERON:0003214 ! mammary gland alveolus +relationship: part_of UBERON:0003214 ! mammary gland alveolus + [Term] id: CL:1000426 name: chromaffin cell of adrenal gland @@ -30195,6 +53600,22 @@ synonym: "adrenal chromaffin cell" EXACT [GO:0061104] xref: FMA:69794 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0002369 ! adrenal gland +relationship: part_of UBERON:0002369 ! adrenal gland + +[Term] +id: CL:1000427 +name: adrenal cortex chromaffin cell +namespace: cell +def: "A chromaffin cell that is part of the adrenal cortex." [GOC:tfm] +comment: Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin. +synonym: "chromaffin cell of adrenal cortex" EXACT [] +xref: FMA:69795 +is_a: CL:1000426 ! chromaffin cell of adrenal gland +is_a: CL:1001601 ! adrenal gland glandular cell +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1000428 @@ -30203,12 +53624,82 @@ namespace: cell def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] synonym: "epidermal stem cell" EXACT [FMA:70541] xref: FMA:70541 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis +[Term] +id: CL:1000432 +name: conjunctival epithelial cell +namespace: cell +def: "An epithelial cell that is part of the conjunctiva." [GOC:tfm] +synonym: "epithelial cell of conjunctiva" EXACT [FMA:70552] +xref: FMA:70552 +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001811 ! conjunctiva +relationship: part_of UBERON:0001811 ! conjunctiva + +[Term] +id: CL:1000434 +name: epithelial cell of external acoustic meatus +namespace: cell +def: "An epithelial cell that is part of the external acoustic meatus." [GOC:tfm] +xref: FMA:70555 +is_a: CL:0000066 {is_inferred="true"} ! epithelial cell +is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001352 ! external acoustic meatus +relationship: part_of UBERON:0001352 ! external acoustic meatus + +[Term] +id: CL:1000435 +name: epithelial cell of lacrimal duct +namespace: cell +def: "An epithelial cell that is part of the lacrimal duct." [GOC:tfm] +xref: FMA:70559 +is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell +intersection_of: CL:0000072 ! non-branched duct epithelial cell +intersection_of: part_of UBERON:0001850 ! lacrimal drainage system +relationship: part_of UBERON:0001850 ! lacrimal drainage system + +[Term] +id: CL:1000436 +name: epithelial cell of lacrimal sac +namespace: cell +def: "An epithelial cell that is part of the lacrimal sac." [GOC:tfm] +xref: FMA:70560 +is_a: CL:0000068 ! duct epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001351 ! lacrimal sac +relationship: part_of UBERON:0001351 ! lacrimal sac + +[Term] +id: CL:1000437 +name: epithelial cell of nasolacrimal duct +namespace: cell +def: "An epithelial cell that is part of the nasolacrimal duct." [GOC:tfm] +xref: FMA:70561 +is_a: CL:1000435 ! epithelial cell of lacrimal duct +intersection_of: CL:0000072 ! non-branched duct epithelial cell +intersection_of: part_of UBERON:0002392 ! nasolacrimal duct +relationship: part_of UBERON:0002392 ! nasolacrimal duct + +[Term] +id: CL:1000442 +name: urothelial cell of trigone of urinary bladder +namespace: cell +def: "An urothelial cell that is part of the trigone of urinary bladder." [GOC:tfm] +synonym: "epithelial cell of vesical trigone" EXACT [FMA:70598] +xref: FMA:70598 +is_a: CL:0000731 {is_inferred="true"} ! urothelial cell +is_a: CL:1001319 ! bladder cell +intersection_of: CL:0000731 ! urothelial cell +intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder +relationship: part_of UBERON:0001257 ! trigone of urinary bladder + [Term] id: CL:1000443 name: ciliary muscle cell @@ -30239,7 +53730,6 @@ namespace: cell def: "A basal cell that is part of the epithelium of esophagus." [GOC:tfm] synonym: "basal cell of esophageal epithelium" EXACT [FMA:70731] xref: FMA:70731 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000646 {is_inferred="true"} ! basal cell intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001976 ! epithelium of esophagus @@ -30253,6 +53743,9 @@ def: "An epithelial cell that is part of the sweat gland." [GOC:tfm] xref: FMA:70952 is_a: CL:0000362 ! epidermal cell is_a: CL:0002308 ! epithelial cell of skin gland +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001820 ! sweat gland +relationship: part_of UBERON:0001820 ! sweat gland [Term] id: CL:1000449 @@ -30261,6 +53754,9 @@ namespace: cell def: "An epithelial cell that is part of the nephron." [GOC:tfm] xref: FMA:70965 is_a: CL:0002518 ! kidney epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001285 ! nephron +relationship: part_of UBERON:0001285 ! nephron [Term] id: CL:1000450 @@ -30272,6 +53768,20 @@ synonym: "epithelial cell of Bowman's capsule" EXACT [FMA:70966] xref: FMA:70966 xref: KUPO:0001034 is_a: CL:1000510 ! kidney glomerular epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001230 ! glomerular capsule +relationship: part_of UBERON:0001230 ! glomerular capsule + +[Term] +id: CL:1000453 +name: epithelial cell of intermediate tubule +namespace: cell +def: "An epithelial cell that is part of the intermediate tubule." [GOC:tfm] +xref: FMA:70980 +is_a: CL:1000909 ! kidney loop of Henle epithelial cell +intersection_of: CL:1000494 ! nephron tubule epithelial cell +intersection_of: part_of UBERON:0004136 ! intermediate tubule +relationship: part_of UBERON:0004136 ! intermediate tubule [Term] id: CL:1000454 @@ -30284,6 +53794,8 @@ xref: KUPO:0001059 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:1000449 ! epithelial cell of nephron is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell +intersection_of: CL:0000072 ! non-branched duct epithelial cell +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1000456 @@ -30320,10 +53832,42 @@ intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002097 ! skin of body relationship: part_of UBERON:0002097 ! skin of body +[Term] +id: CL:1000465 +name: chromaffin cell of ovary +namespace: cell +def: "A chromaffin cell that is part of the ovary." [GOC:tfm] +xref: FMA:74319 +is_a: CL:0000166 {is_inferred="true"} ! chromaffin cell +is_a: CL:2000064 ! ovarian surface epithelial cell +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0000992 ! ovary + +[Term] +id: CL:1000466 +name: chromaffin cell of right ovary +namespace: cell +def: "A chromaffin cell that is part of the right ovary." [GOC:tfm] +xref: FMA:74320 +is_a: CL:1000465 ! chromaffin cell of ovary +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0002118 ! right ovary +relationship: part_of UBERON:0002118 ! right ovary + +[Term] +id: CL:1000467 +name: chromaffin cell of left ovary +namespace: cell +def: "A chromaffin cell that is part of the left ovary." [GOC:tfm] +xref: FMA:74321 +is_a: CL:1000465 ! chromaffin cell of ovary +intersection_of: CL:0000166 ! chromaffin cell +intersection_of: part_of UBERON:0002119 ! left ovary +relationship: part_of UBERON:0002119 ! left ovary + [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node -namespace: cell def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] synonym: "transitinal myocyte of sinuatrial node" EXACT [] xref: FMA:83384 @@ -30346,7 +53890,6 @@ intersection_of: part_of UBERON:0002352 ! atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum -namespace: cell def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] xref: FMA:83390 is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell @@ -30355,6 +53898,41 @@ intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: part_of UBERON:0002094 ! interventricular septum relationship: part_of UBERON:0002094 ! interventricular septum +[Term] +id: CL:1000484 +name: Purkinje myocyte of atrioventricular bundle +namespace: cell +def: "A Purkinje myocyte that is part of the atrioventricular bundle." [GOC:tfm] +xref: FMA:83393 +is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte +is_a: CL:0010005 ! atrioventricular bundle cell +is_a: CL:2000046 ! ventricular cardiac muscle cell +intersection_of: CL:0002068 ! Purkinje myocyte +intersection_of: part_of UBERON:0002353 ! bundle of His + +[Term] +id: CL:1000486 +name: basal cell of urothelium +namespace: cell +def: "A basal cell that is part of the urothelium." [GOC:tfm] +xref: FMA:84150 +is_a: CL:0000646 {is_inferred="true"} ! basal cell +intersection_of: CL:0000646 ! basal cell +intersection_of: part_of UBERON:0000365 ! urothelium +relationship: part_of UBERON:0000365 ! urothelium + +[Term] +id: CL:1000487 +name: smooth muscle cell of prostate +namespace: cell +def: "A smooth muscle cell that is part of the prostate gland." [GOC:tfm] +synonym: "smooth muscle fiber of prostate" EXACT [FMA:84583] +xref: FMA:84583 +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + [Term] id: CL:1000488 name: cholangiocyte @@ -30362,9 +53940,12 @@ namespace: cell def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] synonym: "epithelial cell of bile duct" EXACT [] xref: FMA:86481 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell +intersection_of: CL:0000069 ! branched duct epithelial cell +intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity +intersection_of: part_of UBERON:0002394 ! bile duct relationship: develops_from CL:0005026 ! hepatoblast +relationship: part_of UBERON:0002394 ! bile duct [Term] id: CL:1000490 @@ -30413,6 +53994,21 @@ intersection_of: CL:0000077 ! mesothelial cell intersection_of: part_of UBERON:0002401 ! visceral pleura relationship: part_of UBERON:0002401 ! visceral pleura +[Term] +id: CL:1000494 +name: nephron tubule epithelial cell +namespace: cell +def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm] +comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON. +synonym: "kidney tubule epithelial cell" EXACT [] +xref: FMA:86785 +xref: KUPO:0001022 +is_a: CL:1000449 ! epithelial cell of nephron +is_a: CL:1000507 ! kidney tubule cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0004810 ! nephron tubule epithelium +relationship: part_of UBERON:0004810 ! nephron tubule epithelium + [Term] id: CL:1000495 name: small intestine goblet cell @@ -30424,6 +54020,8 @@ synonym: "small intestinal goblet cell" EXACT [FMA:86929] xref: FMA:86929 is_a: CL:0019031 ! intestine goblet cell is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0002108 ! small intestine [Term] id: CL:1000497 @@ -30432,6 +54030,9 @@ namespace: cell xref: KUPO:0001010 is_a: CL:0000548 {is_inferred="true"} ! animal cell is_a: CL:0002371 ! somatic cell +intersection_of: CL:0000548 ! animal cell +intersection_of: part_of UBERON:0002113 ! kidney +relationship: part_of UBERON:0002113 ! kidney [Term] id: CL:1000500 @@ -30439,6 +54040,9 @@ name: kidney interstitial cell namespace: cell xref: KUPO:0001013 is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0005215 ! kidney interstitium +relationship: part_of UBERON:0005215 ! kidney interstitium [Term] id: CL:1000504 @@ -30446,6 +54050,29 @@ name: kidney medulla cell namespace: cell xref: KUPO:0001017 is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0000362 ! renal medulla +relationship: part_of UBERON:0000362 ! renal medulla + +[Term] +id: CL:1000505 +name: kidney pelvis cell +namespace: cell +xref: KUPO:0001018 +is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0001224 ! renal pelvis +relationship: part_of UBERON:0001224 ! renal pelvis + +[Term] +id: CL:1000507 +name: kidney tubule cell +namespace: cell +xref: KUPO:0001020 +is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0001231 ! nephron tubule +relationship: part_of UBERON:0001231 ! nephron tubule [Term] id: CL:1000510 @@ -30453,6 +54080,84 @@ name: kidney glomerular epithelial cell namespace: cell xref: KUPO:0001023 is_a: CL:1000746 ! glomerular cell +intersection_of: CL:0002518 ! kidney epithelial cell +intersection_of: part_of UBERON:0004188 ! glomerular epithelium +relationship: part_of UBERON:0004188 ! glomerular epithelium + +[Term] +id: CL:1000546 +name: kidney medulla collecting duct epithelial cell +namespace: cell +xref: KUPO:0001060 +is_a: CL:1000504 ! kidney medulla cell +is_a: CL:1001225 ! kidney collecting duct cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct +relationship: part_of UBERON:0005185 ! renal medulla collecting duct + +[Term] +id: CL:1000547 +name: kidney inner medulla collecting duct epithelial cell +namespace: cell +xref: KUPO:0001061 +is_a: CL:1000617 ! kidney inner medulla cell +is_a: CL:1001225 ! kidney collecting duct cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0004205 ! inner medullary collecting duct +relationship: part_of UBERON:0004205 ! inner medullary collecting duct + +[Term] +id: CL:1000548 +name: kidney outer medulla collecting duct epithelial cell +namespace: cell +xref: KUPO:0001062 +is_a: CL:1000616 ! kidney outer medulla cell +is_a: CL:1001225 ! kidney collecting duct cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0004204 ! outer medullary collecting duct +relationship: part_of UBERON:0004204 ! outer medullary collecting duct + +[Term] +id: CL:1000549 +name: kidney cortex collecting duct epithelial cell +namespace: cell +xref: KUPO:0001063 +is_a: CL:0002681 ! kidney cortical cell +is_a: CL:1001225 ! kidney collecting duct cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0004203 ! cortical collecting duct +relationship: part_of UBERON:0004203 ! cortical collecting duct + +[Term] +id: CL:1000600 +name: lower urinary tract cell +namespace: cell +xref: KUPO:0001115 +is_a: CL:0000548 {is_inferred="true"} ! animal cell +intersection_of: CL:0000548 ! animal cell +intersection_of: part_of UBERON:0001556 ! lower urinary tract +relationship: part_of UBERON:0001556 ! lower urinary tract + +[Term] +id: CL:1000601 +name: ureteral cell +namespace: cell +xref: KUPO:0001116 +is_a: CL:0000548 {is_inferred="true"} ! animal cell +intersection_of: CL:0000548 ! animal cell +intersection_of: part_of UBERON:0000056 ! ureter +relationship: part_of UBERON:0000056 ! ureter + +[Term] +id: CL:1000606 +name: kidney nerve cell +namespace: cell +xref: KUPO:0001015 +is_a: CL:0000540 ! neuron +is_a: CL:1000500 ! kidney interstitial cell +intersection_of: CL:0000540 ! neuron +intersection_of: RO:0002100 UBERON:0002113 ! has soma location kidney +relationship: RO:0002100 UBERON:0002113 ! has soma location kidney [Term] id: CL:1000612 @@ -30461,21 +54166,338 @@ namespace: cell xref: KUPO:0001021 is_a: CL:0002584 {is_inferred="true"} ! renal cortical epithelial cell is_a: CL:1000449 ! epithelial cell of nephron +intersection_of: CL:0002584 ! renal cortical epithelial cell +intersection_of: part_of UBERON:0001229 ! renal corpuscle +relationship: part_of UBERON:0001229 ! renal corpuscle + +[Term] +id: CL:1000615 +name: kidney cortex tubule cell +namespace: cell +xref: KUPO:0001024 +is_a: CL:0002584 ! renal cortical epithelial cell +is_a: CL:1000449 ! epithelial cell of nephron +is_a: CL:1000507 {is_inferred="true"} ! kidney tubule cell +intersection_of: CL:1000507 ! kidney tubule cell +intersection_of: part_of UBERON:0006853 ! renal cortex tubule +relationship: part_of UBERON:0006853 ! renal cortex tubule + +[Term] +id: CL:1000616 +name: kidney outer medulla cell +namespace: cell +xref: KUPO:0001025 +is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell +intersection_of: CL:1000504 ! kidney medulla cell +intersection_of: part_of UBERON:0001293 ! outer medulla of kidney +relationship: part_of UBERON:0001293 ! outer medulla of kidney + +[Term] +id: CL:1000617 +name: kidney inner medulla cell +namespace: cell +xref: KUPO:0001026 +is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell +intersection_of: CL:1000504 ! kidney medulla cell +intersection_of: part_of UBERON:0001294 ! inner medulla of kidney +relationship: part_of UBERON:0001294 ! inner medulla of kidney [Term] id: CL:1000618 name: juxtaglomerular complex cell -namespace: cell synonym: "juxtaglomerulus cell" EXACT [GO:0072052] xref: KUPO:0001028 is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell +[Term] +id: CL:1000681 +name: kidney cortex interstitial cell +namespace: cell +xref: KUPO:0001091 +is_a: CL:0002584 ! renal cortical epithelial cell +is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell +intersection_of: CL:1000500 ! kidney interstitial cell +intersection_of: part_of UBERON:0005270 ! renal cortex interstitium +relationship: part_of UBERON:0005270 ! renal cortex interstitium + +[Term] +id: CL:1000682 +name: kidney medulla interstitial cell +namespace: cell +xref: KUPO:0001092 +is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell +is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell +intersection_of: CL:1000500 ! kidney interstitial cell +intersection_of: part_of UBERON:0005211 ! renal medulla interstitium +relationship: part_of UBERON:0005211 ! renal medulla interstitium + +[Term] +id: CL:1000692 +name: kidney interstitial fibroblast +namespace: cell +xref: KUPO:0001102 +is_a: CL:0000057 ! fibroblast +is_a: CL:1000500 ! kidney interstitial cell + +[Term] +id: CL:1000702 +name: kidney pelvis smooth muscle cell +namespace: cell +xref: KUPO:0001113 +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle +relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle + +[Term] +id: CL:1000703 +name: kidney pelvis urothelial cell +namespace: cell +xref: KUPO:0001114 +is_a: CL:0000731 ! urothelial cell +is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell +is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell +intersection_of: CL:0002518 ! kidney epithelial cell +intersection_of: part_of UBERON:0004788 ! kidney pelvis urothelium +relationship: part_of UBERON:0004788 ! kidney pelvis urothelium + +[Term] +id: CL:1000706 +name: ureter urothelial cell +namespace: cell +xref: KUPO:0001117 +is_a: CL:0000731 {is_inferred="true"} ! urothelial cell +is_a: CL:1000601 {is_inferred="true"} ! ureteral cell +intersection_of: CL:0000731 ! urothelial cell +intersection_of: part_of UBERON:0001254 ! urothelium of ureter +relationship: part_of UBERON:0001254 ! urothelium of ureter + +[Term] +id: CL:1000708 +name: ureter adventitial cell +namespace: cell +xref: KUPO:0001119 +is_a: CL:0000115 ! endothelial cell +is_a: CL:0002503 ! adventitial cell +is_a: CL:1000601 {is_inferred="true"} ! ureteral cell +intersection_of: CL:1000601 ! ureteral cell +intersection_of: part_of UBERON:0001252 ! adventitia of ureter +relationship: part_of UBERON:0001252 ! adventitia of ureter + +[Term] +id: CL:1000714 +name: kidney cortex collecting duct principal cell +namespace: cell +xref: KUPO:0001130 +is_a: CL:0002584 ! renal cortical epithelial cell +is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell +is_a: CL:1001431 ! kidney collecting duct principal cell +intersection_of: CL:0005009 ! renal principal cell +intersection_of: part_of UBERON:0004203 ! cortical collecting duct + +[Term] +id: CL:1000716 +name: kidney outer medulla collecting duct principal cell +namespace: cell +xref: KUPO:0001132 +is_a: CL:1000548 {is_inferred="true"} ! kidney outer medulla collecting duct epithelial cell +is_a: CL:1001431 ! kidney collecting duct principal cell +intersection_of: CL:0005009 ! renal principal cell +intersection_of: part_of UBERON:0004204 ! outer medullary collecting duct + +[Term] +id: CL:1000718 +name: kidney inner medulla collecting duct principal cell +namespace: cell +xref: KUPO:0001134 +is_a: CL:1000547 {is_inferred="true"} ! kidney inner medulla collecting duct epithelial cell +is_a: CL:1001431 ! kidney collecting duct principal cell +intersection_of: CL:0005009 ! renal principal cell +intersection_of: part_of UBERON:0004205 ! inner medullary collecting duct + [Term] id: CL:1000746 name: glomerular cell namespace: cell xref: KUPO:0001036 is_a: CL:1000612 {is_inferred="true"} ! kidney corpuscule cell +intersection_of: CL:1000612 ! kidney corpuscule cell +intersection_of: part_of UBERON:0000074 ! renal glomerulus +relationship: part_of UBERON:0000074 ! renal glomerulus + +[Term] +id: CL:1000803 +name: kidney inner medulla interstitial cell +namespace: cell +xref: KUPO:0001093 +is_a: CL:1000617 {is_inferred="true"} ! kidney inner medulla cell +is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell +intersection_of: CL:1000682 ! kidney medulla interstitial cell +intersection_of: part_of UBERON:0005214 ! inner renal medulla interstitium +relationship: part_of UBERON:0005214 ! inner renal medulla interstitium + +[Term] +id: CL:1000804 +name: kidney outer medulla interstitial cell +namespace: cell +xref: KUPO:0001094 +is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell +is_a: CL:1000682 {is_inferred="true"} ! kidney medulla interstitial cell +intersection_of: CL:1000682 ! kidney medulla interstitial cell +intersection_of: part_of UBERON:0005213 ! outer renal medulla interstitium +relationship: part_of UBERON:0005213 ! outer renal medulla interstitium + +[Term] +id: CL:1000838 +name: kidney proximal convoluted tubule epithelial cell +namespace: cell +xref: KUPO:0001045 +is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule +intersection_of: CL:0002306 ! epithelial cell of proximal tubule +intersection_of: part_of UBERON:0001287 ! proximal convoluted tubule +relationship: part_of UBERON:0001287 ! proximal convoluted tubule + +[Term] +id: CL:1000839 +name: kidney proximal straight tubule epithelial cell +namespace: cell +xref: KUPO:0001046 +is_a: CL:0002306 {is_inferred="true"} ! epithelial cell of proximal tubule +is_a: CL:1000616 {is_inferred="true"} ! kidney outer medulla cell +is_a: CL:1001021 ! kidney loop of Henle descending limb epithelial cell +intersection_of: CL:0002306 ! epithelial cell of proximal tubule +intersection_of: part_of UBERON:0001290 ! proximal straight tubule +relationship: part_of UBERON:0001290 ! proximal straight tubule + +[Term] +id: CL:1000849 +name: kidney distal convoluted tubule epithelial cell +namespace: cell +xref: KUPO:0001056 +is_a: CL:0002305 {is_inferred="true"} ! epithelial cell of distal tubule +intersection_of: CL:0002305 ! epithelial cell of distal tubule +intersection_of: part_of UBERON:0001292 ! distal convoluted tubule +relationship: part_of UBERON:0001292 ! distal convoluted tubule + +[Term] +id: CL:1000854 +name: kidney blood vessel cell +namespace: cell +xref: KUPO:0001014 +is_a: CL:0002584 ! renal cortical epithelial cell +is_a: CL:1000504 {is_inferred="true"} ! kidney medulla cell +intersection_of: CL:1000504 ! kidney medulla cell +intersection_of: part_of UBERON:0003517 ! kidney blood vessel +relationship: part_of UBERON:0003517 ! kidney blood vessel +relationship: participates_in GO:0008015 ! blood circulation + +[Term] +id: CL:1000891 +name: kidney arterial blood vessel cell +namespace: cell +xref: KUPO:0001029 +is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell +intersection_of: CL:1000854 ! kidney blood vessel cell +intersection_of: part_of UBERON:0003644 ! kidney arterial blood vessel +relationship: part_of UBERON:0003644 ! kidney arterial blood vessel + +[Term] +id: CL:1000892 +name: kidney capillary endothelial cell +namespace: cell +xref: KUPO:0001030 +is_a: CL:0000071 ! blood vessel endothelial cell +is_a: CL:1000854 ! kidney blood vessel cell +intersection_of: CL:1000854 ! kidney blood vessel cell +intersection_of: part_of UBERON:0003527 ! kidney capillary +relationship: part_of UBERON:0003527 ! kidney capillary + +[Term] +id: CL:1000893 +name: kidney venous blood vessel cell +namespace: cell +xref: KUPO:0001031 +is_a: CL:1000854 {is_inferred="true"} ! kidney blood vessel cell +intersection_of: CL:1000854 ! kidney blood vessel cell +intersection_of: part_of UBERON:0001140 ! renal vein +relationship: part_of UBERON:0001140 ! renal vein + +[Term] +id: CL:1000909 +name: kidney loop of Henle epithelial cell +namespace: cell +xref: KUPO:0001047 +is_a: CL:1000494 {is_inferred="true"} ! nephron tubule epithelial cell +intersection_of: CL:1000494 ! nephron tubule epithelial cell +intersection_of: part_of UBERON:0001288 ! loop of Henle +relationship: part_of UBERON:0001288 ! loop of Henle + +[Term] +id: CL:1000979 +name: ureter smooth muscle cell +namespace: cell +xref: KUPO:0001118 +is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +is_a: CL:1000601 {is_inferred="true"} ! ureteral cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: part_of UBERON:0006855 ! muscular coat of ureter +relationship: part_of UBERON:0006855 ! muscular coat of ureter + +[Term] +id: CL:1001005 +name: glomerular capillary endothelial cell +namespace: cell +xref: KUPO:0001037 +is_a: CL:0002144 ! capillary endothelial cell +is_a: CL:0002188 ! glomerular endothelial cell +is_a: CL:1000510 ! kidney glomerular epithelial cell +is_a: CL:1000892 {is_inferred="true"} ! kidney capillary endothelial cell +intersection_of: CL:1000892 ! kidney capillary endothelial cell +intersection_of: part_of UBERON:0004294 ! glomerular capillary endothelium +relationship: part_of UBERON:0004294 ! glomerular capillary endothelium + +[Term] +id: CL:1001021 +name: kidney loop of Henle descending limb epithelial cell +namespace: cell +xref: KUPO:0001053 +is_a: CL:1000909 {is_inferred="true"} ! kidney loop of Henle epithelial cell +intersection_of: CL:1000909 ! kidney loop of Henle epithelial cell +intersection_of: part_of UBERON:0001289 ! descending limb of loop of Henle +relationship: part_of UBERON:0001289 ! descending limb of loop of Henle + +[Term] +id: CL:1001045 +name: kidney cortex artery cell +namespace: cell +xref: KUPO:0001077 +is_a: CL:1000891 {is_inferred="true"} ! kidney arterial blood vessel cell +intersection_of: CL:1000891 ! kidney arterial blood vessel cell +intersection_of: part_of UBERON:0005268 ! renal cortex artery +relationship: part_of UBERON:0005268 ! renal cortex artery + +[Term] +id: CL:1001052 +name: kidney cortex vein cell +namespace: cell +xref: KUPO:0001084 +is_a: CL:1000893 {is_inferred="true"} ! kidney venous blood vessel cell +intersection_of: CL:1000893 ! kidney venous blood vessel cell +intersection_of: part_of UBERON:0005269 ! renal cortex vein +relationship: part_of UBERON:0005269 ! renal cortex vein + +[Term] +id: CL:1001111 +name: kidney loop of Henle thin descending limb epithelial cell +namespace: cell +xref: KUPO:0001054 +is_a: CL:1000453 ! epithelial cell of intermediate tubule +is_a: CL:1000616 ! kidney outer medulla cell +is_a: CL:1001021 {is_inferred="true"} ! kidney loop of Henle descending limb epithelial cell +intersection_of: CL:1001021 ! kidney loop of Henle descending limb epithelial cell +intersection_of: part_of UBERON:0005096 ! descending thin limb +relationship: part_of UBERON:0005096 ! descending thin limb [Term] id: CL:1001225 @@ -30484,14 +54506,62 @@ namespace: cell xref: KUPO:0001012 xref: Wikipedia:Kidney_collecting_duct_cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell +intersection_of: CL:1000497 ! kidney cell +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule +relationship: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001318 name: renal interstitial pericyte namespace: cell +def: "A pericyte cell located in the kidney interstitium." [] xref: KUPO:0001104 is_a: CL:0000669 {is_inferred="true"} ! pericyte cell -is_a: CL:1000497 ! kidney cell +is_a: CL:1000500 ! kidney interstitial cell +intersection_of: CL:0000669 ! pericyte cell +intersection_of: part_of UBERON:0002113 ! kidney + +[Term] +id: CL:1001319 +name: bladder cell +namespace: cell +xref: KUPO:0001120 +is_a: CL:1000600 ! lower urinary tract cell +intersection_of: CL:0000548 ! animal cell +intersection_of: part_of UBERON:0001255 ! urinary bladder +relationship: part_of UBERON:0001255 ! urinary bladder + +[Term] +id: CL:1001320 +name: urethra cell +namespace: cell +xref: KUPO:0001123 +is_a: CL:1000600 ! lower urinary tract cell +intersection_of: CL:0000548 ! animal cell +intersection_of: part_of UBERON:0000057 ! urethra +relationship: part_of UBERON:0000057 ! urethra + +[Term] +id: CL:1001428 +name: bladder urothelial cell +namespace: cell +xref: KUPO:0001121 +is_a: CL:0000731 {is_inferred="true"} ! urothelial cell +is_a: CL:1001319 {is_inferred="true"} ! bladder cell +intersection_of: CL:0000731 ! urothelial cell +intersection_of: part_of UBERON:0004645 ! urinary bladder urothelium +relationship: part_of UBERON:0004645 ! urinary bladder urothelium + +[Term] +id: CL:1001430 +name: urethra urothelial cell +namespace: cell +xref: KUPO:0001124 +is_a: CL:0000731 {is_inferred="true"} ! urothelial cell +is_a: CL:1000296 ! epithelial cell of urethra +intersection_of: CL:0000731 ! urothelial cell +intersection_of: part_of UBERON:0004787 ! urethra urothelium +relationship: part_of UBERON:0004787 ! urethra urothelium [Term] id: CL:1001431 @@ -30500,11 +54570,12 @@ namespace: cell xref: KUPO:0001128 is_a: CL:0005009 {is_inferred="true"} ! renal principal cell is_a: CL:1000454 ! kidney collecting duct epithelial cell +intersection_of: CL:0005009 ! renal principal cell +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule [Term] id: CL:1001432 name: kidney collecting duct intercalated cell -namespace: cell xref: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells xref: KUPO:0001129 is_a: CL:0005010 {is_inferred="true"} ! renal intercalated cell @@ -30518,6 +54589,9 @@ def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] synonym: "exocrine pancreas cell" EXACT [] xref: FMA:70986 is_a: CL:0000083 ! epithelial cell of pancreas +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0000017 ! exocrine pancreas +relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: CL:1001434 @@ -30527,40 +54601,40 @@ def: "A neuron residing in the olfactory bulb that serve to process and refine s is_a: CL:0000101 ! sensory neuron is_a: CL:0000402 ! CNS interneuron is_a: CL:0012001 ! neuron of the forebrain +intersection_of: CL:0000099 ! interneuron +intersection_of: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb +relationship: part_of UBERON:0002264 ! olfactory bulb +relationship: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb [Term] id: CL:1001435 name: periglomerular cell -namespace: cl def: "The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter." [MP:0009943] -synonym: "glomerular layer cell" EXACT [NIFSTD:nifext_122] -synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIFSTD:nifext_122] -synonym: "olfactory bulb glomerular layer cell" EXACT [NIFSTD:nifext_122] +synonym: "glomerular layer cell" EXACT [NIFEXT:122] +synonym: "olfactory bulb (accessory) glomerular layer cell" EXACT [NIFEXT:122] +synonym: "olfactory bulb glomerular layer cell" EXACT [NIFEXT:122] synonym: "olfactory bulb glomerularal cell" EXACT [MP:0009943] synonym: "olfactory bulb periglomerular cell" EXACT [] -synonym: "periglomerular cell" EXACT [NIFSTD:nifext_122] +synonym: "periglomerular cell" EXACT [NIFEXT:122] xref: BTO:0003796 -xref: NIFSTD:nifext_122 +xref: NIFEXT:122 is_a: CL:1001434 ! olfactory bulb interneuron [Term] id: CL:1001436 name: hair-tylotrich neuron -namespace: cl def: "The subcutaneous mechanoreceptors that innervate tylotrich hair follicles." [MP:0000977] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001437 name: hair-down neuron -namespace: cl def: "The subcutaneous mechanoreceptors that innervate vellus hairs." [MP:0000979] is_a: CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell [Term] id: CL:1001451 name: sensory neuron of dorsal root ganglion -namespace: cl def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297] synonym: "proprioceptive neuron" EXACT [MP:0004297] is_a: CL:0000101 {is_inferred="true"} ! sensory neuron @@ -30568,7 +54642,6 @@ is_a: CL:0000101 {is_inferred="true"} ! sensory neuron [Term] id: CL:1001474 name: medium spiny neuron -namespace: cl def: "The inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus." [MP:0008462] synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778] synonym: "striatal medium spiny neuron" EXACT [GO:0021773] @@ -30578,21 +54651,18 @@ is_a: CL:0000540 ! neuron [Term] id: CL:1001502 name: mitral cell -namespace: cl def: "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex." [MP:0009954] is_a: CL:1001434 ! olfactory bulb interneuron [Term] id: CL:1001503 name: olfactory bulb tufted cell -namespace: cl def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." [MP:0009955] is_a: CL:0000540 ! neuron [Term] id: CL:1001505 name: parvocellular neurosecretory cell -namespace: cl def: "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system." [MP:0010125] synonym: "parvocellular neuron" EXACT [] synonym: "parvocellular neurosecretory neuron" EXACT [] @@ -30603,7 +54673,6 @@ is_a: CL:2000030 ! hypothalamus cell [Term] id: CL:1001509 name: glycinergic neuron -namespace: cl def: "The neurons that utilize glycine as a neurotransmitter." [MP:0010385] is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron @@ -30615,6 +54684,8 @@ namespace: cl def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: part_of UBERON:0001242 ! intestinal mucosa [Term] id: CL:1001517 @@ -30623,18 +54694,19 @@ namespace: cl def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." [MP:0010803] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: part_of UBERON:0001160 ! fundus of stomach +relationship: part_of UBERON:0001160 ! fundus of stomach [Term] id: CL:1001561 name: vomeronasal sensory neuron -namespace: cl def: "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals." [MP:0011679] -is_a: CL:0000006 ! neuronal receptor cell +is_a: CL:0000101 ! sensory neuron [Term] id: CL:1001566 name: bronchioalveolar stem cells -namespace: cl def: "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury." [MP:0011691] is_a: CL:0000034 ! stem cell @@ -30661,16 +54733,66 @@ intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0005317 ! pulmonary artery endothelium +[Term] +id: CL:1001569 +name: hippocampal interneuron +namespace: cl +def: "An interneuron of the hippocampus." [GOC:pr] +xref: FMA:84777 +is_a: CL:0000099 ! interneuron +intersection_of: CL:0000099 ! interneuron +intersection_of: part_of UBERON:0001954 ! Ammon's horn +relationship: part_of UBERON:0001954 ! Ammon's horn + [Term] id: CL:1001571 name: hippocampal pyramidal neuron -namespace: cl def: "A pyramidal neuron of the hippocampus." [GOC:pr, PMID:19342486] synonym: "hippocampus (CA) pyramidal cell" EXACT [NIFSTD:sao131261273] synonym: "hippocampus (CA) pyramidal neuron" EXACT [NIFSTD:sao131261273] xref: NIFSTD:sao131261273 xref: SAO:sao131261273 -is_a: CL:0000598 ! pyramidal neuron +is_a: CL:4023111 ! cerebral cortex pyramidal neuron + +[Term] +id: CL:1001572 +name: colon endothelial cell +def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] +synonym: "colon endothelial cells" RELATED PLURAL [CALOHA:TS-2397] +synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397] +xref: CALOHA:TS-2397 +is_a: CL:0000115 ! endothelial cell +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0001155 ! colon +relationship: part_of UBERON:0013695 ! colon endothelium + +[Term] +id: CL:1001573 +name: nasopharyngeal epithelial cell +def: "Cell of the nasopharyngeal epithelium." [NPX:PDR] +synonym: "nasopharynx respiratory epithelial cells" RELATED [CALOHA:TS-2398] +xref: CALOHA:TS-2398 +is_a: CL:0002251 ! epithelial cell of alimentary canal +is_a: CL:0002631 ! epithelial cell of upper respiratory tract +intersection_of: CL:0000066 ! epithelial cell +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001951 ! epithelium of nasopharynx + +[Term] +id: CL:1001575 +name: uterine cervix squamous cell +def: "Squamous cell of uterine cervix epithelium." [NPX:PDR] +synonym: "cervix squamous cell" RELATED [CALOHA:TS-1251] +synonym: "cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] +synonym: "cervix, uterine squamous epithelial cells" RELATED [CALOHA:TS-1251] +synonym: "uterine cervix squamous epithelial cell" RELATED [CALOHA:TS-1251] +synonym: "uterine cervix squamous epithelial cells" RELATED [CALOHA:TS-1251] +xref: CALOHA:TS-1251 +is_a: CL:0000076 ! squamous epithelial cell +is_a: CL:0002535 ! epithelial cell of cervix +intersection_of: CL:0000076 ! squamous epithelial cell +intersection_of: part_of UBERON:0000002 ! uterine cervix [Term] id: CL:1001576 @@ -30687,6 +54809,35 @@ intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: part_of UBERON:0002424 ! oral epithelium +[Term] +id: CL:1001577 +name: tonsil squamous cell +def: "Squamous cell of tonsil epithelium." [NPX:PDR] +synonym: "tonsil squamous epithelial cell" RELATED [CALOHA:TS-1253] +synonym: "tonsil squamous epithelial cells" RELATED [CALOHA:TS-1253] +synonym: "tonsillar squamous cell" RELATED [CALOHA:TS-1253] +synonym: "tonsillar squamous epithelial cell" RELATED [CALOHA:TS-1253] +xref: CALOHA:TS-1253 +is_a: CL:0000076 ! squamous epithelial cell +is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000076 ! squamous epithelial cell +intersection_of: part_of UBERON:0002372 ! tonsil +relationship: part_of UBERON:0013696 ! tonsil epithelium + +[Term] +id: CL:1001578 +name: vagina squamous cell +def: "Squamous cell of vaginal epithelium." [NPX:PDR] +synonym: "vagina squamous epithelial cell" RELATED [CALOHA:TS-1254] +synonym: "vagina squamous epithelial cells" RELATED [CALOHA:TS-1254] +synonym: "vaginal squamous cell" RELATED [CALOHA:TS-1254] +synonym: "vaginal squamous epithelial cell" RELATED [CALOHA:TS-1254] +xref: CALOHA:TS-1254 +is_a: CL:0000076 ! squamous epithelial cell +intersection_of: CL:0000076 ! squamous epithelial cell +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0001344 ! epithelium of vagina + [Term] id: CL:1001579 name: cerebral cortex glial cell @@ -30700,6 +54851,97 @@ intersection_of: CL:0000125 ! glial cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex +[Term] +id: CL:1001580 +name: hippocampus glial cell +def: "Glial cell of hippocampus." [NPX:PDR] +synonym: "hippocampal glial cell" RELATED [CALOHA:TS-1257] +synonym: "hippocampus glial cells" RELATED [CALOHA:TS-1257] +synonym: "hippocampus neuroglial cell" RELATED [CALOHA:TS-1257] +xref: CALOHA:TS-1257 +is_a: CL:1001579 ! cerebral cortex glial cell +intersection_of: CL:0000125 ! glial cell +intersection_of: part_of UBERON:0001954 ! Ammon's horn +relationship: part_of UBERON:0001954 ! Ammon's horn + +[Term] +id: CL:1001581 +name: lateral ventricle glial cell +def: "Glial cell of lateral ventricle." [NPX:PDR] +synonym: "lateral ventricle glial cells" RELATED [CALOHA:TS-1258] +xref: CALOHA:TS-1258 +is_a: CL:0000125 ! glial cell +intersection_of: CL:0000125 ! glial cell +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle +relationship: part_of UBERON:0002285 ! telencephalic ventricle + +[Term] +id: CL:1001582 +name: lateral ventricle neuron +def: "Neuron of lateral ventricle." [NPX:PDR] +synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261] +synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261] +synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261] +xref: CALOHA:TS-1261 +is_a: CL:2000029 ! central nervous system neuron +intersection_of: CL:0000540 ! neuron +intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle +relationship: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle + +[Term] +id: CL:1001585 +name: appendix glandular cell +def: "Glandular cell of appendix epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +synonym: "appendix glandular cells" RELATED [CALOHA:TS-1271] +synonym: "caecal appendix glandular cell" RELATED [CALOHA:TS-1271] +synonym: "cecal appendix glandular cell" RELATED [CALOHA:TS-1271] +synonym: "vermiform appendix glandular cell" RELATED [CALOHA:TS-1271] +xref: CALOHA:TS-1271 +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:1000405 ! epithelial cell of appendix +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0009697 ! epithelium of appendix + +[Term] +id: CL:1001586 +name: mammary gland glandular cell +def: "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts." [HPA:HPA, NPX:PDR] +synonym: "breast glandular cell" RELATED [CALOHA:TS-1272] +synonym: "breast glandular cells" RELATED [CALOHA:TS-1272] +synonym: "mammary glandular cell" RELATED [CALOHA:TS-1272] +xref: CALOHA:TS-1272 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000152 ! exocrine cell +is_a: CL:0002327 ! mammary gland epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0003244 ! epithelium of mammary gland + +[Term] +id: CL:1001587 +name: uterine cervix glandular cell +def: "Glandular cell of uterine cervix epithelium." [NPX:PDR] +synonym: "cervix glandular cell" RELATED [CALOHA:TS-1273] +synonym: "cervix, uterine glandular cell" RELATED [CALOHA:TS-1273] +synonym: "cervix, uterine glandular cells" RELATED [CALOHA:TS-1273] +xref: CALOHA:TS-1273 +is_a: CL:0002535 ! epithelial cell of cervix +is_a: CL:1001591 ! oviduct glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0000002 ! uterine cervix + +[Term] +id: CL:1001588 +name: colon glandular cell +def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +synonym: "colon glandular cells" RELATED [CALOHA:TS-1274] +xref: CALOHA:TS-1274 +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001155 ! colon + [Term] id: CL:1001589 name: duodenum glandular cell @@ -30707,6 +54949,49 @@ def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275] xref: CALOHA:TS-1275 is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0008346 ! duodenal epithelium + +[Term] +id: CL:1001590 +name: epididymis glandular cell +def: "Glandular cell of epididymal epithelium." [NPX:PDR] +synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276] +synonym: "epididymis glandular cells" RELATED [CALOHA:TS-1276] +xref: CALOHA:TS-1276 +is_a: CL:0000068 ! duct epithelial cell +is_a: CL:0000150 ! glandular epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001301 ! epididymis +relationship: part_of UBERON:0004544 ! epididymis epithelium + +[Term] +id: CL:1001591 +name: oviduct glandular cell +def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [HPA:HPA, NPX:PDR] +synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277] +synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277] +synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277] +xref: CALOHA:TS-1277 +is_a: CL:0000150 ! glandular epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0000993 ! oviduct +relationship: part_of UBERON:0004804 ! oviduct epithelium + +[Term] +id: CL:1001592 +name: gall bladder glandular cell +def: "Glandular cell of gall bladder epithelium." [NPX:PDR] +synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278] +synonym: "gallbladder glandular cell" RELATED [CALOHA:TS-1278] +synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278] +xref: CALOHA:TS-1278 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:1000415 ! epithelial cell of gall bladder +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002029 ! epithelium of gall bladder [Term] id: CL:1001593 @@ -30716,6 +55001,46 @@ synonym: "parathyroid gland glandular cell" RELATED [CALOHA:TS-1279] synonym: "parathyroid gland glandular cells" RELATED [CALOHA:TS-1279] xref: CALOHA:TS-1279 is_a: CL:0000150 ! glandular epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001132 ! parathyroid gland +relationship: part_of UBERON:0011197 ! parathyroid epithelium + +[Term] +id: CL:1001595 +name: rectum glandular cell +def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281] +synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281] +xref: CALOHA:TS-1281 +is_a: CL:0002658 ! glandular cell of the large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001052 ! rectum +relationship: part_of UBERON:0003354 ! epithelium of rectum + +[Term] +id: CL:1001596 +name: salivary gland glandular cell +def: "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts." [HPA:HPA, NPX:PDR] +synonym: "salivary gland glandular cells" RELATED [CALOHA:TS-1282] +xref: CALOHA:TS-1282 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000152 ! exocrine cell +is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland +relationship: part_of UBERON:0004809 ! salivary gland epithelium + +[Term] +id: CL:1001597 +name: seminal vesicle glandular cell +def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR] +synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283] +xref: CALOHA:TS-1283 +is_a: CL:0000068 ! duct epithelial cell +is_a: CL:0000150 ! glandular epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0000998 ! seminal vesicle +relationship: part_of UBERON:0004805 ! seminal vesicle epithelium [Term] id: CL:1001598 @@ -30728,6 +55053,9 @@ xref: CALOHA:TS-1286 xref: FMA:86928 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0001902 ! epithelium of small intestine [Term] id: CL:1001599 @@ -30740,6 +55068,9 @@ xref: CALOHA:TS-1242 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000152 ! exocrine cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0000017 ! exocrine pancreas +relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium [Term] id: CL:1001601 @@ -30750,6 +55081,9 @@ synonym: "adrenal glandular cell" RELATED [CALOHA:TS-2177] synonym: "suprarenal gland glandular cell" RELATED [CALOHA:TS-2177] xref: CALOHA:TS-2177 is_a: CL:0000150 ! glandular epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: part_of UBERON:0001235 ! adrenal cortex +relationship: part_of UBERON:0001235 ! adrenal cortex [Term] id: CL:1001602 @@ -30776,6 +55110,37 @@ intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung +[Term] +id: CL:1001606 +name: foreskin keratinocyte +def: "Keratinocyte from foreskin." [NPX:PDR] +xref: CALOHA:TS-0385 +is_a: CL:0000312 ! keratinocyte +intersection_of: CL:0000312 ! keratinocyte +intersection_of: part_of UBERON:0001332 ! prepuce of penis +relationship: part_of UBERON:0001332 ! prepuce of penis + +[Term] +id: CL:1001607 +name: articular chondrocyte +def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR] +xref: CALOHA:TS-0056 +is_a: CL:0000138 ! chondrocyte +intersection_of: CL:0000138 ! chondrocyte +intersection_of: part_of UBERON:0010996 ! articular cartilage of joint +relationship: part_of UBERON:0010996 ! articular cartilage of joint + +[Term] +id: CL:1001608 +name: foreskin fibroblast +def: "Fibroblast from foreskin." [NPX:PDR] +synonym: "BJ fibroblast" EXACT [] +xref: CALOHA:TS-0384 +is_a: CL:0002620 ! skin fibroblast +intersection_of: CL:0002620 ! skin fibroblast +intersection_of: part_of UBERON:0001332 ! prepuce of penis +relationship: part_of UBERON:0001332 ! prepuce of penis + [Term] id: CL:1001609 name: muscle fibroblast @@ -30807,6 +55172,9 @@ synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359] xref: CALOHA:TS-2359 xref: FMA:84665 is_a: CL:2000029 ! central nervous system neuron +intersection_of: CL:0000540 ! neuron +intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum +relationship: RO:0002100 UBERON:0002037 ! has soma location cerebellum [Term] id: CL:2000000 @@ -30841,6 +55209,9 @@ name: pituitary gland cell namespace: cell def: "Any cell that is part of a pituitary gland." [GOC:TermGenie] is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: part_of UBERON:0000007 ! pituitary gland +relationship: part_of UBERON:0000007 ! pituitary gland created_by: TermGenie creation_date: 2014-03-26T22:14:56Z @@ -30856,6 +55227,18 @@ relationship: part_of UBERON:0000955 ! brain created_by: TermGenie creation_date: 2014-03-28T21:35:27Z +[Term] +id: CL:2000007 +name: articular chondrocyte of knee joint +namespace: cell +def: "Chondrocyte forming the hyaline cartilage found in the knee joint." [GOC:TermGenie] +is_a: CL:1001607 ! articular chondrocyte +intersection_of: CL:1001607 ! articular chondrocyte +intersection_of: part_of UBERON:0001485 ! knee joint +relationship: part_of UBERON:0001485 ! knee joint +created_by: TermGenie +creation_date: 2014-06-04T14:40:11Z + [Term] id: CL:2000008 name: microvascular endothelial cell @@ -30880,6 +55263,30 @@ relationship: part_of UBERON:0002067 ! dermis created_by: TermGenie creation_date: 2014-06-04T15:12:06Z +[Term] +id: CL:2000011 +name: dermis lymphatic vessel endothelial cell +namespace: cell +def: "Any endothelial cell of lymphatic vessel that is part of a dermis." [GOC:TermGenie] +is_a: CL:0002138 ! endothelial cell of lymphatic vessel +intersection_of: CL:0002138 ! endothelial cell of lymphatic vessel +intersection_of: part_of UBERON:0002067 ! dermis +relationship: part_of UBERON:0002067 ! dermis +created_by: TermGenie +creation_date: 2014-06-04T15:15:08Z + +[Term] +id: CL:2000012 +name: fibroblast of pedal digit skin +namespace: cell +def: "Any skin fibroblast that is part of a pedal digit skin." [GOC:TermGenie] +is_a: CL:0002620 ! skin fibroblast +intersection_of: CL:0002620 ! skin fibroblast +intersection_of: part_of UBERON:0003530 ! pedal digit skin +relationship: part_of UBERON:0003530 ! pedal digit skin +created_by: TermGenie +creation_date: 2014-06-04T15:16:44Z + [Term] id: CL:2000013 name: fibroblast of skin of abdomen @@ -30892,6 +55299,30 @@ relationship: part_of UBERON:0001416 ! skin of abdomen created_by: TermGenie creation_date: 2014-06-04T15:18:16Z +[Term] +id: CL:2000014 +name: fibroblast of upper leg skin +namespace: cell +def: "Any skin fibroblast that is part of a upper leg skin." [GOC:TermGenie] +is_a: CL:0002620 ! skin fibroblast +intersection_of: CL:0002620 ! skin fibroblast +intersection_of: part_of UBERON:0004262 ! upper leg skin +relationship: part_of UBERON:0004262 ! upper leg skin +created_by: TermGenie +creation_date: 2014-06-04T15:19:44Z + +[Term] +id: CL:2000015 +name: fibroblast of arm +namespace: cell +def: "Any skin fibroblast that is part of a arm." [GOC:TermGenie] +is_a: CL:0002620 ! skin fibroblast +intersection_of: CL:0002620 ! skin fibroblast +intersection_of: part_of UBERON:0001460 ! arm +relationship: part_of UBERON:0001460 ! arm +created_by: TermGenie +creation_date: 2014-06-04T15:29:06Z + [Term] id: CL:2000016 name: lung microvascular endothelial cell @@ -30904,11 +55335,36 @@ intersection_of: part_of UBERON:0008339 ! microvascular endothelium created_by: TermGenie creation_date: 2014-06-04T16:00:56Z +[Term] +id: CL:2000017 +name: fibroblast of peridontal ligament +namespace: cell +def: "Any fibroblast that is part of a periodontal ligament." [GOC:TermGenie] +is_a: CL:0002556 ! fibroblast of periodontium +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0008266 ! periodontal ligament +relationship: part_of UBERON:0008266 ! periodontal ligament +created_by: TermGenie +creation_date: 2014-06-04T16:50:33Z + +[Term] +id: CL:2000018 +name: endothelial cell of coronary artery +namespace: cell +def: "Any endothelial cell of artery that is part of a coronary artery." [GOC:TermGenie] +is_a: CL:0010006 ! cardiac blood vessel endothelial cell +is_a: CL:1000413 ! endothelial cell of artery +intersection_of: CL:1000413 ! endothelial cell of artery +intersection_of: part_of UBERON:0001621 ! coronary artery +relationship: part_of UBERON:0001621 ! coronary artery +created_by: TermGenie +creation_date: 2014-06-04T17:08:47Z + [Term] id: CL:2000019 name: compound eye photoreceptor cell -namespace: cell def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] +xref: FBbt:00004211 is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: part_of UBERON:0000018 ! compound eye @@ -30916,12 +55372,27 @@ relationship: part_of UBERON:0000018 ! compound eye created_by: TermGenie creation_date: 2014-06-24T23:16:45Z +[Term] +id: CL:2000020 +name: inner cell mass cell +namespace: cell +def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] +is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: part_of UBERON:0000087 ! inner cell mass +relationship: part_of UBERON:0000087 ! inner cell mass +created_by: TermGenie +creation_date: 2014-06-24T23:16:53Z + [Term] id: CL:2000021 name: sebaceous gland cell namespace: cell def: "Any native cell that is part of a sebaceous gland." [GOC:TermGenie] is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: part_of UBERON:0001821 ! sebaceous gland +relationship: part_of UBERON:0001821 ! sebaceous gland created_by: TermGenie creation_date: 2014-06-24T23:17:00Z @@ -30930,7 +55401,6 @@ id: CL:2000022 name: cardiac septum cell namespace: cell def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0002099 ! cardiac septum @@ -30941,7 +55411,6 @@ creation_date: 2014-06-24T23:17:07Z [Term] id: CL:2000025 name: spinal cord oligodendrocyte -namespace: cell def: "Any oligodendrocyte that is part of a spinal cord." [GOC:TermGenie] is_a: CL:0000128 ! oligodendrocyte intersection_of: CL:0000128 ! oligodendrocyte @@ -30950,6 +55419,30 @@ relationship: part_of UBERON:0002240 ! spinal cord created_by: TermGenie creation_date: 2014-06-25T00:23:50Z +[Term] +id: CL:2000027 +name: cerebellum basket cell +namespace: cell +def: "Any basket cell that is part of a cerebellum." [GOC:TermGenie] +is_a: CL:0000118 ! basket cell +intersection_of: CL:0000118 ! basket cell +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum +created_by: TermGenie +creation_date: 2014-06-25T00:24:03Z + +[Term] +id: CL:2000028 +name: cerebellum glutamatergic neuron +namespace: cell +def: "Any glutamatergic neuron that is part of a cerebellum." [GOC:TermGenie] +is_a: CL:0000679 ! glutamatergic neuron +intersection_of: CL:0000679 ! glutamatergic neuron +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum +created_by: TermGenie +creation_date: 2014-06-25T00:24:10Z + [Term] id: CL:2000029 name: central nervous system neuron @@ -30968,6 +55461,9 @@ name: hypothalamus cell namespace: cell def: "Any native cell that is part of a hypothalamus." [GOC:TermGenie] is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: part_of UBERON:0001898 ! hypothalamus +relationship: part_of UBERON:0001898 ! hypothalamus created_by: TermGenie creation_date: 2014-06-25T01:17:50Z @@ -30975,7 +55471,12 @@ creation_date: 2014-06-25T01:17:50Z id: CL:2000032 name: peripheral nervous system neuron namespace: cell +alt_id: CL:0000111 +def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] def: "Any neuron that is part of a peripheral nervous system." [GOC:TermGenie] +synonym: "peripheral neuron" EXACT [] +synonym: "PNS neuron" EXACT [] +xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous system @@ -30983,6 +55484,42 @@ relationship: RO:0002100 UBERON:0000010 ! has soma location peripheral nervous s created_by: TermGenie creation_date: 2014-06-25T02:28:17Z +[Term] +id: CL:2000033 +name: limb basal cell of epidermis +namespace: cell +def: "Any basal cell of epidermis that is part of a limb." [GOC:TermGenie] +is_a: CL:0002187 ! basal cell of epidermis +intersection_of: CL:0002187 ! basal cell of epidermis +intersection_of: part_of UBERON:0002101 ! limb +relationship: part_of UBERON:0002101 ! limb +created_by: TermGenie +creation_date: 2014-06-25T02:28:25Z + +[Term] +id: CL:2000040 +name: bladder microvascular endothelial cell +namespace: cell +def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie] +is_a: CL:1001319 ! bladder cell +is_a: CL:2000008 ! microvascular endothelial cell +intersection_of: CL:2000008 ! microvascular endothelial cell +intersection_of: part_of UBERON:0001255 ! urinary bladder +created_by: TermGenie +creation_date: 2014-07-09T00:04:47Z + +[Term] +id: CL:2000041 +name: dermis microvascular lymphatic vessel endothelial cell +namespace: cell +def: "Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] +is_a: CL:2000011 ! dermis lymphatic vessel endothelial cell +intersection_of: CL:2000011 ! dermis lymphatic vessel endothelial cell +intersection_of: part_of UBERON:0008339 ! microvascular endothelium +relationship: part_of UBERON:0008339 ! microvascular endothelium +created_by: TermGenie +creation_date: 2014-07-09T00:09:54Z + [Term] id: CL:2000042 name: embryonic fibroblast @@ -30995,6 +55532,18 @@ relationship: part_of UBERON:0000922 ! embryo created_by: TermGenie creation_date: 2014-07-09T00:12:00Z +[Term] +id: CL:2000043 +name: brain pericyte +namespace: cell +def: "Any pericyte cell that is part of a brain." [GOC:TermGenie] +is_a: CL:0002575 ! central nervous system pericyte +intersection_of: CL:0000669 ! pericyte cell +intersection_of: part_of UBERON:0000955 ! brain +relationship: part_of UBERON:0000955 ! brain +created_by: TermGenie +creation_date: 2014-07-09T00:18:22Z + [Term] id: CL:2000044 name: brain microvascular endothelial cell @@ -31008,6 +55557,18 @@ relationship: part_of UBERON:0000955 ! brain created_by: TermGenie creation_date: 2014-07-09T00:24:53Z +[Term] +id: CL:2000045 +name: foreskin melanocyte +namespace: cell +def: "Any melanocyte that is part of a prepuce of penis." [GOC:TermGenie] +is_a: CL:0000148 ! melanocyte +intersection_of: CL:0000148 ! melanocyte +intersection_of: part_of UBERON:0001332 ! prepuce of penis +relationship: part_of UBERON:0001332 ! prepuce of penis +created_by: TermGenie +creation_date: 2014-07-09T00:45:07Z + [Term] id: CL:2000046 name: ventricular cardiac muscle cell @@ -31023,7 +55584,6 @@ creation_date: 2014-08-12T20:50:28Z [Term] id: CL:2000047 name: brainstem motor neuron -namespace: cell def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron @@ -31033,6 +55593,86 @@ relationship: RO:0002100 UBERON:0002298 ! has soma location brainstem created_by: TermGenie creation_date: 2014-10-02T23:52:53Z +[Term] +id: CL:2000051 +name: splenic fibroblast +namespace: cell +def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0002106 ! spleen +relationship: part_of UBERON:0002106 ! spleen +created_by: TermGenie +creation_date: 2014-10-06T18:58:47Z + +[Term] +id: CL:2000052 +name: umbilical artery endothelial cell +namespace: cell +def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010 +is_a: CL:0000349 ! extraembryonic cell +is_a: CL:1000413 ! endothelial cell of artery +intersection_of: CL:1000413 ! endothelial cell of artery +intersection_of: part_of UBERON:0002331 ! umbilical cord +relationship: part_of UBERON:0002331 ! umbilical cord +created_by: TermGenie +creation_date: 2014-10-06T19:01:48Z + +[Term] +id: CL:2000053 +name: splenic endothelial cell +namespace: cell +def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: part_of UBERON:0002106 ! spleen +relationship: part_of UBERON:0002106 ! spleen +created_by: TermGenie +creation_date: 2014-10-06T19:06:04Z + +[Term] +id: CL:2000055 +name: liver dendritic cell +namespace: cell +def: "Any dendritic cell that is part of a liver." [GOC:TermGenie] +comment: http://www.jleukbio.org/content/66/2/322.abstract +synonym: "hepatic dendritic cell" EXACT [] +is_a: CL:0000451 ! dendritic cell +intersection_of: CL:0000451 ! dendritic cell +intersection_of: part_of UBERON:0002107 ! liver +relationship: part_of UBERON:0002107 ! liver +created_by: TermGenie +creation_date: 2014-10-06T19:16:11Z + +[Term] +id: CL:2000057 +name: femural osteoblast +namespace: cell +def: "Any osteoblast that is part of a femur." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4610 +is_a: CL:0000062 ! osteoblast +is_a: CL:0001035 ! bone cell +intersection_of: CL:0000062 ! osteoblast +intersection_of: part_of UBERON:0000981 ! femur +relationship: part_of UBERON:0000981 ! femur +created_by: TermGenie +creation_date: 2014-10-06T19:29:45Z + +[Term] +id: CL:2000059 +name: prostate gland microvascular endothelial cell +namespace: cell +def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400 +is_a: CL:2000008 ! microvascular endothelial cell +intersection_of: CL:2000008 ! microvascular endothelial cell +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland +created_by: TermGenie +creation_date: 2014-10-07T17:46:27Z + [Term] id: CL:2000060 name: placental villous trophoblast @@ -31044,10 +55684,40 @@ synonym: "villous cytotrophoblast" EXACT [] xref: BTO:0006119 xref: BTO:0006208 is_a: CL:0000351 ! trophoblast cell +intersection_of: CL:0000351 ! trophoblast cell +intersection_of: part_of UBERON:0010005 ! placental labyrinth villous +relationship: part_of UBERON:0010005 ! placental labyrinth villous property_value: seeAlso http://www.sciencellonline.com/site/productInformation.php?keyword=7120 xsd:string created_by: TermGenie creation_date: 2014-10-07T17:48:27Z +[Term] +id: CL:2000061 +name: placental amniotic mesenchymal stromal cell +namespace: cell +def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140 +is_a: CL:0000134 ! mesenchymal stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta +created_by: TermGenie +creation_date: 2014-10-07T17:51:11Z + +[Term] +id: CL:2000062 +name: placental villus capillary endothelial cell +namespace: cell +def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie] +comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/ +is_a: CL:0002144 ! capillary endothelial cell +is_a: CL:0009092 ! endothelial cell of placenta +intersection_of: CL:0002144 ! capillary endothelial cell +intersection_of: part_of UBERON:0010005 ! placental labyrinth villous +relationship: part_of UBERON:0010005 ! placental labyrinth villous +created_by: TermGenie +creation_date: 2014-10-07T17:55:56Z + [Term] id: CL:2000063 name: ovarian fibroblast @@ -31067,7 +55737,6 @@ name: ovarian surface epithelial cell namespace: cell def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 -is_a: CARO:0000000 ! anatomical entity is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000992 ! ovary @@ -31075,6 +55744,20 @@ relationship: part_of UBERON:0000992 ! ovary created_by: TermGenie creation_date: 2014-10-07T17:59:13Z +[Term] +id: CL:2000065 +name: ovarian microvascular endothelial cell +namespace: cell +def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300 +is_a: CL:1000296 ! epithelial cell of urethra +is_a: CL:2000008 ! microvascular endothelial cell +intersection_of: CL:2000008 ! microvascular endothelial cell +intersection_of: part_of UBERON:0001334 ! female urethra +relationship: part_of UBERON:0001334 ! female urethra +created_by: TermGenie +creation_date: 2014-10-07T18:18:01Z + [Term] id: CL:2000066 name: cardiac ventricle fibroblast @@ -31114,6 +55797,19 @@ relationship: part_of UBERON:0002407 ! pericardium created_by: TermGenie creation_date: 2014-10-07T18:38:06Z +[Term] +id: CL:2000069 +name: gallbladder fibroblast +namespace: cell +def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder +created_by: TermGenie +creation_date: 2014-10-07T18:41:43Z + [Term] id: CL:2000070 name: optic choroid fibroblast @@ -31127,6 +55823,19 @@ relationship: part_of UBERON:0001776 ! optic choroid created_by: TermGenie creation_date: 2014-10-07T18:50:43Z +[Term] +id: CL:2000071 +name: mammary microvascular endothelial cell +namespace: cell +def: "Any microvascular endothelial cell that is part of a breast." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7600 +is_a: CL:2000008 ! microvascular endothelial cell +intersection_of: CL:2000008 ! microvascular endothelial cell +intersection_of: part_of UBERON:0000310 ! breast +relationship: part_of UBERON:0000310 ! breast +created_by: TermGenie +creation_date: 2014-10-07T19:55:30Z + [Term] id: CL:2000072 name: adipose microvascular endothelial cell @@ -31160,9 +55869,48 @@ namespace: cell def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. is_a: CL:0000738 ! leukocyte +intersection_of: CL:0000738 ! leukocyte +intersection_of: part_of UBERON:0002106 ! spleen +relationship: part_of UBERON:0002106 ! spleen created_by: TermGenie creation_date: 2014-11-05T01:26:50Z +[Term] +id: CL:2000076 +name: hindlimb stylopod vein endothelial cell +namespace: cell +def: "Any vein endothelial cell that is part of a hindlimb stylopod." [GOC:TermGenie] +is_a: CL:0002543 ! vein endothelial cell +intersection_of: CL:0002543 ! vein endothelial cell +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod +relationship: part_of UBERON:0000376 ! hindlimb stylopod +created_by: TermGenie +creation_date: 2014-12-02T18:40:47Z + +[Term] +id: CL:2000078 +name: placental pericyte +namespace: cell +def: "Any pericyte cell that is part of a placenta." [GOC:TermGenie] +is_a: CL:0000669 ! pericyte cell +intersection_of: CL:0000669 ! pericyte cell +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta +created_by: TermGenie +creation_date: 2014-12-02T18:51:03Z + +[Term] +id: CL:2000079 +name: mesenchymal stem cell of femoral bone marrow +namespace: cell +def: "Any mesenchymal stem cell of the bone marrow that is part of a femur." [GOC:TermGenie] +is_a: CL:0002540 ! mesenchymal stem cell of the bone marrow +intersection_of: CL:0002540 ! mesenchymal stem cell of the bone marrow +intersection_of: part_of UBERON:0000981 ! femur +relationship: part_of UBERON:0000981 ! femur +created_by: TermGenie +creation_date: 2014-12-02T19:07:31Z + [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue @@ -31188,6 +55936,143 @@ relationship: part_of UBERON:1000021 ! skin of face created_by: TermGenie creation_date: 2014-12-02T19:10:40Z +[Term] +id: CL:2000082 +name: melanocyte of foreskin +namespace: cell +def: "Any melanocyte of skin that is part of a skin of prepuce of penis." [GOC:TermGenie] +is_a: CL:1000458 ! melanocyte of skin +is_a: CL:2000045 ! foreskin melanocyte +intersection_of: CL:1000458 ! melanocyte of skin +intersection_of: part_of UBERON:0001471 ! skin of prepuce of penis +relationship: part_of UBERON:0001471 ! skin of prepuce of penis +created_by: TermGenie +creation_date: 2014-12-02T19:10:45Z + +[Term] +id: CL:2000084 +name: conjunctiva goblet cell +namespace: cell +def: "Any goblet cell that is part of a conjunctiva." [GOC:TermGenie] +is_a: CL:0000160 ! goblet cell +is_a: CL:1000432 ! conjunctival epithelial cell +intersection_of: CL:0000160 ! goblet cell +intersection_of: part_of UBERON:0001811 ! conjunctiva +created_by: TermGenie +creation_date: 2014-12-02T19:28:38Z + +[Term] +id: CL:2000085 +name: mononuclear cell of umbilical cord +namespace: cell +def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie] +is_a: CL:0000349 ! extraembryonic cell +is_a: CL:0000842 ! mononuclear cell +intersection_of: CL:0000842 ! mononuclear cell +intersection_of: part_of UBERON:0002331 ! umbilical cord +relationship: part_of UBERON:0002331 ! umbilical cord +created_by: TermGenie +creation_date: 2014-12-02T20:14:16Z + +[Term] +id: CL:2000086 +name: neocortex basket cell +namespace: cell +def: "Any basket cell that is part of a neocortex." [GOC:TermGenie] +is_a: CL:0000118 ! basket cell +intersection_of: CL:0000118 ! basket cell +intersection_of: part_of UBERON:0001950 ! neocortex +relationship: part_of UBERON:0001950 ! neocortex +created_by: TermGenie +creation_date: 2014-12-24T00:37:19Z + +[Term] +id: CL:2000087 +name: dentate gyrus of hippocampal formation basket cell +namespace: cell +def: "Any basket cell that is part of a dentate gyrus of hippocampal formation." [GOC:TermGenie] +is_a: CL:0000118 ! basket cell +intersection_of: CL:0000118 ! basket cell +intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation +relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation +created_by: TermGenie +creation_date: 2014-12-24T00:37:24Z + +[Term] +id: CL:2000088 +name: Ammon's horn basket cell +namespace: cell +def: "Any basket cell that is part of a Ammon's horn." [GOC:TermGenie] +is_a: CL:0000118 ! basket cell +is_a: CL:1001569 ! hippocampal interneuron +intersection_of: CL:0000118 ! basket cell +intersection_of: part_of UBERON:0001954 ! Ammon's horn +created_by: TermGenie +creation_date: 2014-12-24T00:37:30Z + +[Term] +id: CL:2000089 +name: dentate gyrus of hippocampal formation granule cell +namespace: cell +def: "The principal cell type of the dentate gyrus." [GOC:TermGenie] +comment: The granule cell has a characteristic cone-shaped tree of spiny apical dendrites. +is_a: CL:0001032 ! cortical granule cell +intersection_of: CL:0000120 ! granule cell +intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation +relationship: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation +created_by: TermGenie +creation_date: 2015-02-23T05:48:23Z + +[Term] +id: CL:2000091 +name: endometrial microvascular endothelial cells +namespace: cell +def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie] +is_a: CL:0009095 ! endothelial cell of uterus +is_a: CL:2000008 ! microvascular endothelial cell +intersection_of: CL:2000008 ! microvascular endothelial cell +intersection_of: part_of UBERON:0015172 ! endometrial blood vessel +relationship: part_of UBERON:0015172 ! endometrial blood vessel +created_by: TermGenie +creation_date: 2015-03-31T21:02:36Z + +[Term] +id: CL:2000092 +name: hair follicular keratinocyte +namespace: cell +def: "Any keratinocyte that is part of a hair follicle." [GOC:TermGenie] +is_a: CL:0000312 ! keratinocyte +is_a: CL:0002559 ! hair follicle cell +intersection_of: CL:0000312 ! keratinocyte +intersection_of: part_of UBERON:0002073 ! hair follicle +created_by: TermGenie +creation_date: 2015-03-31T21:07:02Z + +[Term] +id: CL:2000093 +name: bronchus fibroblast of lung +namespace: cell +def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] +is_a: CL:0002553 ! fibroblast of lung +intersection_of: CL:0002553 ! fibroblast of lung +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus +created_by: TermGenie +creation_date: 2015-03-31T21:16:22Z + +[Term] +id: CL:2000095 +name: cord blood hematopoietic stem cell +namespace: cell +def: "Any hematopoietic stem cell that is part of a umbilical cord blood." [GOC:TermGenie] +is_a: CL:0002246 ! peripheral blood stem cell +is_a: CL:0002352 ! gestational hematopoietic stem cell +intersection_of: CL:0000037 ! hematopoietic stem cell +intersection_of: part_of UBERON:0012168 ! umbilical cord blood +relationship: part_of UBERON:0012168 ! umbilical cord blood +created_by: TermGenie +creation_date: 2015-05-26T18:58:34Z + [Term] id: CL:3000000 name: ciliated epithelial cell of esophagus @@ -31201,6 +56086,36 @@ relationship: part_of UBERON:0001976 ! epithelium of esophagus created_by: CellBLAST creation_date: 2019-02-09T16:40:30Z +[Term] +id: CL:3000004 +name: peripheral sensory neuron +def: "Peripheral sensory neuron." [GOC:CellBLAST, PMID:30096314] +is_a: CL:0000101 ! sensory neuron +is_a: CL:2000032 ! peripheral nervous system neuron +intersection_of: CL:2000032 ! peripheral nervous system neuron +intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception +created_by: CellBLAST +creation_date: 2019-02-25T19:34:33Z + +[Term] +id: CL:4006000 +name: fibroblast of breast +def: "A fibroblast that is part of the breast." [] +synonym: "breast fibroblast" EXACT [] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: part_of UBERON:0000310 ! breast +relationship: part_of UBERON:0000310 ! breast +property_value: created_by http://orcid.org/0000-0001-9897-3238 + +[Term] +id: CL:4023111 +name: cerebral cortex pyramidal neuron +def: "A pyramidal neuron with soma located in the cerebral cortex." [PMID:30715238] +is_a: CL:0000598 ! pyramidal neuron +is_a: CL:0010012 ! cerebral cortex neuron +property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-7258-9596 + [Term] id: CL:4023120 name: cochlea auditory hair cell @@ -31211,6 +56126,17 @@ is_a: CL:0000202 ! auditory hair cell is_a: CL:0002374 ! ear hair cell property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0001-7258-9596 +[Term] +id: CL:4023154 +name: myelinating glial cell +alt_id: CL:0000328 +def: "A glial cell that myelinates axonal processes." [DOI:10.1007/3-540-29623-9_3240] +is_a: CL:0000125 ! glial cell +intersection_of: CL:0000125 ! glial cell +intersection_of: has_part GO:0043209 ! myelin sheath +relationship: dc-contributor http://orcid.org/0000-0001-7258-9596 +relationship: has_part GO:0043209 ! myelin sheath + [Term] id: CL:4028001 name: pulmonary capillary endothelial cell @@ -31223,6 +56149,2159 @@ intersection_of: part_of UBERON:0002048 ! lung created_by: http://orcid.org/0000-0002-3293-5463 creation_date: 2021-11-23T02:31:40Z +[Term] +id: CL:4030000 +name: choroidal melanocyte +def: "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses." [http://orcid.org/0000-0002-0819-0473, PMID:31819095] +comment: Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins. {xref="PMID:34082079", xref="PMID:31819095"} +synonym: "uveal melanocyte" EXACT [] +is_a: CL:0000148 ! melanocyte +intersection_of: CL:0000148 ! melanocyte +intersection_of: part_of UBERON:0001768 ! uvea +relationship: part_of UBERON:0001768 ! uvea +property_value: dc-contributor http://orcid.org/0000-0002-1773-2692 xsd:string +creation_date: 2022-01-20T12:59:06Z + +[Term] +id: ECTO:0000015 +name: exposure to environmental material +def: "A exposure event involving the interaction of an exposure receptor to environmental material." [] +synonym: "environmental material exposure" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process + +[Term] +id: ECTO:0000135 +name: exposure to organic compound +def: "An exposure to organic molecular entity." [] +synonym: "exposure to organic molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:50860 ! has exposure stimulus organic molecular entity +relationship: RO:0002309 CHEBI:50860 ! has exposure stimulus organic molecular entity + +[Term] +id: ECTO:0000163 +name: exposure to organic cyclic compound +def: "An exposure to organic cyclic compound." [] +synonym: "exposure to organic cyclic compound" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33832 ! has exposure stimulus organic cyclic compound +relationship: RO:0002309 CHEBI:33832 ! has exposure stimulus organic cyclic compound + +[Term] +id: ECTO:0000173 +name: exposure to corticosteroid +def: "An exposure to corticosteroid." [] +synonym: "exposure to corticosteroid" EXACT [] +is_a: ECTO:0002002 ! exposure to steroid +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:50858 ! has exposure stimulus corticosteroid +relationship: RO:0002309 CHEBI:50858 ! has exposure stimulus corticosteroid + +[Term] +id: ECTO:0000200 +name: exposure to lipid +def: "An exposure to lipid." [] +synonym: "exposure to lipid" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:18059 ! has exposure stimulus lipid +relationship: RO:0002309 CHEBI:18059 ! has exposure stimulus lipid + +[Term] +id: ECTO:0000231 +name: exposure to chemical +def: "An exposure to chemical entity." [] +synonym: "exposure to chemical entity" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24431 ! has exposure stimulus chemical entity +relationship: RO:0002309 CHEBI:24431 ! has exposure stimulus chemical entity + +[Term] +id: ECTO:0000258 +name: exposure to steroid hormone +def: "An exposure to steroid hormone." [] +synonym: "exposure to steroid hormone" EXACT [] +is_a: ECTO:0002002 ! exposure to steroid +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:26764 ! has exposure stimulus steroid hormone +relationship: RO:0002309 CHEBI:26764 ! has exposure stimulus steroid hormone + +[Term] +id: ECTO:0000259 +name: exposure to glucocorticoid +def: "An exposure to glucocorticoid." [] +synonym: "exposure to glucocorticoid" EXACT [] +is_a: ECTO:0000173 ! exposure to corticosteroid +is_a: ECTO:0000258 ! exposure to steroid hormone +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24261 ! has exposure stimulus glucocorticoid +relationship: RO:0002309 CHEBI:24261 ! has exposure stimulus glucocorticoid + +[Term] +id: ECTO:0000371 +name: exposure to oxygen molecular entity +def: "An exposure to oxygen molecular entity." [] +synonym: "exposure to oxygen molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:25806 ! has exposure stimulus oxygen molecular entity +relationship: RO:0002309 CHEBI:25806 ! has exposure stimulus oxygen molecular entity + +[Term] +id: ECTO:0000481 +name: exposure to transition element +def: "An exposure to transition element molecular entity." [] +synonym: "exposure to transition element molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33497 ! has exposure stimulus transition element molecular entity +relationship: RO:0002309 CHEBI:33497 ! has exposure stimulus transition element molecular entity + +[Term] +id: ECTO:0000485 +name: exposure to chemical with biological effect +def: "An exposure to biological role." [] +synonym: "exposure to biological role" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24432 ! has exposure stimulus biological role +relationship: RO:0002309 CHEBI:24432 ! has exposure stimulus biological role + +[Term] +id: ECTO:0000486 +name: exposure to chemical with application +def: "An exposure to application." [] +synonym: "exposure to application" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33232 ! has exposure stimulus application +relationship: RO:0002309 CHEBI:33232 ! has exposure stimulus application + +[Term] +id: ECTO:0000487 +name: exposure to chemical with chemical role +def: "An exposure to chemical role." [] +synonym: "exposure to chemical role" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:51086 ! has exposure stimulus chemical role +relationship: RO:0002309 CHEBI:51086 ! has exposure stimulus chemical role + +[Term] +id: ECTO:0000509 +name: exposure to drug +def: "An exposure to drug." [] +synonym: "exposure to drug" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:23888 ! has exposure stimulus drug +relationship: RO:0002309 CHEBI:23888 ! has exposure stimulus drug + +[Term] +id: ECTO:0000516 +name: exposure to hormone +def: "An exposure to hormone." [] +synonym: "exposure to hormone" EXACT [] +is_a: ECTO:0000543 ! exposure to molecular messenger +is_a: ECTO:0000672 ! exposure to agonist +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24621 ! has exposure stimulus hormone +relationship: RO:0002309 CHEBI:24621 ! has exposure stimulus hormone + +[Term] +id: ECTO:0000526 +name: exposure to neurotransmitter +def: "An exposure to neurotransmitter." [] +synonym: "exposure to neurotransmitter" EXACT [] +is_a: ECTO:0000543 ! exposure to molecular messenger +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:25512 ! has exposure stimulus neurotransmitter +relationship: RO:0002309 CHEBI:25512 ! has exposure stimulus neurotransmitter + +[Term] +id: ECTO:0000543 +name: exposure to molecular messenger +def: "An exposure to molecular messenger." [] +synonym: "exposure to molecular messenger" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33280 ! has exposure stimulus molecular messenger +relationship: RO:0002309 CHEBI:33280 ! has exposure stimulus molecular messenger + +[Term] +id: ECTO:0000544 +name: exposure to antimicrobial agent +def: "An exposure to antimicrobial agent." [] +synonym: "exposure to antimicrobial agent" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33281 ! has exposure stimulus antimicrobial agent +relationship: RO:0002309 CHEBI:33281 ! has exposure stimulus antimicrobial agent + +[Term] +id: ECTO:0000557 +name: exposure to inhibitor +def: "An exposure to inhibitor." [] +synonym: "exposure to inhibitor" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35222 ! has exposure stimulus inhibitor +relationship: RO:0002309 CHEBI:35222 ! has exposure stimulus inhibitor + +[Term] +id: ECTO:0000590 +name: exposure to vasodilator agent +def: "An exposure to vasodilator agent." [] +synonym: "exposure to vasodilator agent" EXACT [] +is_a: ECTO:0000509 ! exposure to drug +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35620 ! has exposure stimulus vasodilator agent +relationship: RO:0002309 CHEBI:35620 ! has exposure stimulus vasodilator agent + +[Term] +id: ECTO:0000650 +name: exposure to Bronsted acid +def: "An exposure to Bronsted acid." [] +synonym: "exposure to Bronsted acid" EXACT [] +is_a: ECTO:9002146 ! exposure to acids +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:39141 ! has exposure stimulus Bronsted acid +relationship: RO:0002309 CHEBI:39141 ! has exposure stimulus Bronsted acid + +[Term] +id: ECTO:0000672 +name: exposure to agonist +def: "An exposure to agonist." [] +synonym: "exposure to agonist" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:48705 ! has exposure stimulus agonist +relationship: RO:0002309 CHEBI:48705 ! has exposure stimulus agonist + +[Term] +id: ECTO:0000726 +name: exposure to allergen +def: "An exposure to allergen." [] +synonym: "exposure to allergen" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:50904 ! has exposure stimulus allergen +relationship: RO:0002309 CHEBI:50904 ! has exposure stimulus allergen + +[Term] +id: ECTO:0000730 +name: exposure to neurotoxin +def: "An exposure to neurotoxin." [] +synonym: "exposure to neurotoxin" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:50910 ! has exposure stimulus neurotoxin +relationship: RO:0002309 CHEBI:50910 ! has exposure stimulus neurotoxin + +[Term] +id: ECTO:0000922 +name: exposure to EC 3.5.1.4 (amidase) inhibitor +def: "An exposure to EC 3.5.1.4 (amidase) inhibitor." [] +synonym: "exposure to EC 3.5.1.4 (amidase) inhibitor" EXACT [] +is_a: ECTO:0000557 ! exposure to inhibitor +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:77941 ! has exposure stimulus EC 3.5.1.4 (amidase) inhibitor +relationship: RO:0002309 CHEBI:77941 ! has exposure stimulus EC 3.5.1.4 (amidase) inhibitor + +[Term] +id: ECTO:0000931 +name: exposure to environmental contaminant +def: "An exposure to environmental contaminant." [] +synonym: "exposure to environmental contaminant" EXACT [] +is_a: ECTO:0000487 ! exposure to chemical with chemical role +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:78298 ! has exposure stimulus environmental contaminant +relationship: RO:0002309 CHEBI:78298 ! has exposure stimulus environmental contaminant + +[Term] +id: ECTO:0001057 +name: exposure to decreased temperature +def: "A exposure event involving the interaction of an exposure receptor to decreased temperature." [] +synonym: "decreased temperature exposure" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality +is_a: ECTO:0010003 ! exposure to environmental physical object quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001306 ! has exposure stimulus decreased temperature +relationship: RO:0002309 PATO:0001306 ! has exposure stimulus decreased temperature + +[Term] +id: ECTO:0001082 +name: exposure to alcohol consumption +def: "An exposure event involving Alcohol Consumption" [] +synonym: "Alcohol Consumption exposure" EXACT [] +is_a: ECTO:6000016 ! exposure to personal behavior +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 NCIT:C16273 ! has exposure stimulus Alcohol Consumption +relationship: RO:0002309 NCIT:C16273 ! has exposure stimulus Alcohol Consumption + +[Term] +id: ECTO:0002002 +name: exposure to steroid +def: "An exposure to steroid." [] +synonym: "exposure to steroid" EXACT [] +is_a: ECTO:0000163 ! exposure to organic cyclic compound +is_a: ECTO:0000200 ! exposure to lipid +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35341 ! has exposure stimulus steroid +relationship: RO:0002309 CHEBI:35341 ! has exposure stimulus steroid + +[Term] +id: ECTO:0010000 +name: exposure to environmental quality +def: "A exposure event involving the interaction of an exposure receptor to quality." [] +synonym: "quality exposure" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0000001 ! has exposure stimulus quality +relationship: RO:0002309 PATO:0000001 ! has exposure stimulus quality + +[Term] +id: ECTO:0010001 +name: exposure to qualitative environmental quality +def: "A exposure event involving the interaction of an exposure receptor to qualitative." [] +synonym: "qualitative exposure" EXACT [] +is_a: ECTO:0010000 ! exposure to environmental quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0000068 ! has exposure stimulus qualitative +relationship: RO:0002309 PATO:0000068 ! has exposure stimulus qualitative + +[Term] +id: ECTO:0010002 +name: exposure to environmental process quality +def: "A exposure event involving the interaction of an exposure receptor to process quality." [] +synonym: "process quality exposure" EXACT [] +is_a: ECTO:0010000 ! exposure to environmental quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001236 ! has exposure stimulus process quality +relationship: RO:0002309 PATO:0001236 ! has exposure stimulus process quality + +[Term] +id: ECTO:0010003 +name: exposure to environmental physical object quality +def: "A exposure event involving the interaction of an exposure receptor to physical object quality." [] +synonym: "physical object quality exposure" EXACT [] +is_a: ECTO:0010000 ! exposure to environmental quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001241 ! has exposure stimulus physical object quality +relationship: RO:0002309 PATO:0001241 ! has exposure stimulus physical object quality + +[Term] +id: ECTO:3000000 +name: exposure to organism +def: "A history of exposure to root." [] +synonym: "root exposure" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 NCBITaxon:1 ! has exposure stimulus root +relationship: RO:0002309 NCBITaxon:1 ! has exposure stimulus root + +[Term] +id: ECTO:3000001 +name: exposure to virus +def: "A history of exposure to Viruses." [] +synonym: "Viruses exposure" EXACT [] +is_a: ECTO:3000000 ! exposure to organism +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 NCBITaxon:10239 ! has exposure stimulus Viruses +relationship: RO:0002309 NCBITaxon:10239 ! has exposure stimulus Viruses + +[Term] +id: ECTO:3000005 +name: exposure to humans +def: "A history of exposure to Homo sapiens." [] +synonym: "Homo sapiens exposure" EXACT [] +is_a: ECTO:0000015 ! exposure to environmental material +is_a: ECTO:3000000 ! exposure to organism +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 NCBITaxon:9606 ! has exposure stimulus Homo sapiens +relationship: RO:0002309 NCBITaxon:9606 ! has exposure stimulus Homo sapiens + +[Term] +id: ECTO:4000000 +name: exposure to change +def: "A exposure event involving the interaction of an exposure receptor to deviation (from_normal) of quality." [] +synonym: "exposure to deviation (from_normal) in quality" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality + +[Term] +id: ECTO:4000001 +name: exposure to increased temperature +def: "A exposure event involving the interaction of an exposure receptor to increased temperature." [] +synonym: "increased temperature exposure" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality +is_a: ECTO:0010003 ! exposure to environmental physical object quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001305 ! has exposure stimulus increased temperature +relationship: RO:0002309 PATO:0001305 ! has exposure stimulus increased temperature + +[Term] +id: ECTO:4000002 +name: exposure to increased salt +def: "A exposure event involving the interaction of an exposure receptor to increased amount of salt." [] +synonym: "exposure to increased amount in salt" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality + +[Term] +id: ECTO:4000003 +name: exposure to decreased salt +def: "A exposure event involving the interaction of an exposure receptor to decreased amount of salt." [] +synonym: "exposure to decreased amount in salt" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality + +[Term] +id: ECTO:4000025 +name: exposure to increased pressure +def: "A exposure event involving the interaction of an exposure receptor to increased pressure." [] +synonym: "increased pressure exposure" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality +is_a: ECTO:0010003 ! exposure to environmental physical object quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001576 ! has exposure stimulus increased pressure +relationship: RO:0002309 PATO:0001576 ! has exposure stimulus increased pressure + +[Term] +id: ECTO:4000026 +name: exposure to decreased pressure +def: "A exposure event involving the interaction of an exposure receptor to decreased pressure." [] +synonym: "decreased pressure exposure" EXACT [] +is_a: ECTO:0010001 ! exposure to qualitative environmental quality +is_a: ECTO:0010003 ! exposure to environmental physical object quality +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 PATO:0001575 ! has exposure stimulus decreased pressure +relationship: RO:0002309 PATO:0001575 ! has exposure stimulus decreased pressure + +[Term] +id: ECTO:6000016 +name: exposure to personal behavior +def: "An exposure event involving Personal Behavior" [] +synonym: "Personal Behavior exposure" EXACT [] +is_a: ExO:0000002 ! exposure event +is_a: RO:0002310 ! exposure event or process +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 NCIT:C19683 ! has exposure stimulus Personal Behavior +relationship: RO:0002309 NCIT:C19683 ! has exposure stimulus Personal Behavior + +[Term] +id: ECTO:9000016 +name: exposure to hydrogen chloride +def: "An exposure to hydrogen chloride." [] +synonym: "exposure to hydrogen chloride" EXACT [] +is_a: ECTO:9000077 ! exposure to chlorine +is_a: ECTO:9001628 ! exposure to gas molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:17883 ! has exposure stimulus hydrogen chloride +relationship: RO:0002309 CHEBI:17883 ! has exposure stimulus hydrogen chloride + +[Term] +id: ECTO:9000019 +name: exposure to acetic acid +def: "An exposure to acetic acid." [] +synonym: "exposure to acetic acid" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:15366 ! has exposure stimulus acetic acid +relationship: RO:0002309 CHEBI:15366 ! has exposure stimulus acetic acid + +[Term] +id: ECTO:9000021 +name: exposure to alkali metal salt +def: "An exposure to alkali metal salt." [] +synonym: "exposure to alkali metal salt" EXACT [] +is_a: ECTO:9000409 ! exposure to salt +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35479 ! has exposure stimulus alkali metal salt +relationship: RO:0002309 CHEBI:35479 ! has exposure stimulus alkali metal salt + +[Term] +id: ECTO:9000026 +name: exposure to alcohol +def: "An exposure to alcohol." [] +synonym: "exposure to alcohol" EXACT [] +is_a: ECTO:0000015 ! exposure to environmental material +is_a: ECTO:0000135 ! exposure to organic compound +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:30879 ! has exposure stimulus alcohol +relationship: RO:0002309 CHEBI:30879 ! has exposure stimulus alcohol + +[Term] +id: ECTO:9000044 +name: exposure to ketone +def: "An exposure to ketone." [] +synonym: "exposure to ketone" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:17087 ! has exposure stimulus ketone +relationship: RO:0002309 CHEBI:17087 ! has exposure stimulus ketone + +[Term] +id: ECTO:9000049 +name: exposure to carbon dioxide +def: "An exposure to carbon dioxide." [] +synonym: "exposure to carbon dioxide" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +is_a: ECTO:9001628 ! exposure to gas molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:16526 ! has exposure stimulus carbon dioxide +relationship: RO:0002309 CHEBI:16526 ! has exposure stimulus carbon dioxide + +[Term] +id: ECTO:9000077 +name: exposure to chlorine +def: "An exposure to chlorine molecular entity." [] +synonym: "exposure to chlorine molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:23117 ! has exposure stimulus chlorine molecular entity +relationship: RO:0002309 CHEBI:23117 ! has exposure stimulus chlorine molecular entity + +[Term] +id: ECTO:9000107 +name: exposure to solvent +def: "An exposure to solvent." [] +synonym: "exposure to solvent" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +is_a: ECTO:0000487 ! exposure to chemical with chemical role +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:46787 ! has exposure stimulus solvent +relationship: RO:0002309 CHEBI:46787 ! has exposure stimulus solvent + +[Term] +id: ECTO:9000156 +name: exposure to water +def: "An exposure to water." [] +synonym: "exposure to water" EXACT [] +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +is_a: ECTO:9000172 ! exposure to inorganic compound +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:15377 ! has exposure stimulus water +relationship: RO:0002309 CHEBI:15377 ! has exposure stimulus water + +[Term] +id: ECTO:9000171 +name: exposure to acetate +def: "An exposure to acetate." [] +synonym: "exposure to acetate" EXACT [] +is_a: ECTO:0000135 ! exposure to organic compound +is_a: ECTO:0000371 ! exposure to oxygen molecular entity +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:30089 ! has exposure stimulus acetate +relationship: RO:0002309 CHEBI:30089 ! has exposure stimulus acetate + +[Term] +id: ECTO:9000172 +name: exposure to inorganic compound +def: "An exposure to inorganic molecular entity." [] +synonym: "exposure to inorganic molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24835 ! has exposure stimulus inorganic molecular entity +relationship: RO:0002309 CHEBI:24835 ! has exposure stimulus inorganic molecular entity + +[Term] +id: ECTO:9000175 +name: exposure to metal cation +def: "An exposure to metal cation." [] +synonym: "exposure to metal cation" EXACT [] +is_a: ECTO:9000172 ! exposure to inorganic compound +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:25213 ! has exposure stimulus metal cation +relationship: RO:0002309 CHEBI:25213 ! has exposure stimulus metal cation + +[Term] +id: ECTO:9000404 +name: exposure to nitrogen +def: "An exposure to nitrogen molecular entity." [] +synonym: "exposure to nitrogen molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:51143 ! has exposure stimulus nitrogen molecular entity +relationship: RO:0002309 CHEBI:51143 ! has exposure stimulus nitrogen molecular entity + +[Term] +id: ECTO:9000409 +name: exposure to salt +def: "An exposure to salt." [] +synonym: "exposure to salt" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:24866 ! has exposure stimulus salt +relationship: RO:0002309 CHEBI:24866 ! has exposure stimulus salt + +[Term] +id: ECTO:9001334 +name: exposure to primary alcohol +def: "An exposure to primary alcohol." [] +synonym: "exposure to primary alcohol" EXACT [] +is_a: ECTO:9000026 ! exposure to alcohol +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:15734 ! has exposure stimulus primary alcohol +relationship: RO:0002309 CHEBI:15734 ! has exposure stimulus primary alcohol + +[Term] +id: ECTO:9001347 +name: exposure to sodium chloride +def: "An exposure to sodium chloride." [] +synonym: "exposure to sodium chloride" EXACT [] +is_a: ECTO:9000021 ! exposure to alkali metal salt +is_a: ECTO:9000077 ! exposure to chlorine +is_a: ECTO:9000172 ! exposure to inorganic compound +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:26710 ! has exposure stimulus sodium chloride +relationship: RO:0002309 CHEBI:26710 ! has exposure stimulus sodium chloride + +[Term] +id: ECTO:9001627 +name: exposure to inorganic acid +def: "An exposure to inorganic acid." [] +synonym: "exposure to inorganic acid" EXACT [] +is_a: ECTO:0000650 ! exposure to Bronsted acid +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:138103 ! has exposure stimulus inorganic acid +relationship: RO:0002309 CHEBI:138103 ! has exposure stimulus inorganic acid + +[Term] +id: ECTO:9001628 +name: exposure to gas molecular entity +def: "An exposure to gas molecular entity." [] +synonym: "exposure to gas molecular entity" EXACT [] +is_a: ECTO:0000231 ! exposure to chemical +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:138675 ! has exposure stimulus gas molecular entity +relationship: RO:0002309 CHEBI:138675 ! has exposure stimulus gas molecular entity + +[Term] +id: ECTO:9001630 +name: exposure to endocrine disruptor +def: "An exposure to endocrine disruptor." [] +synonym: "exposure to endocrine disruptor" EXACT [] +is_a: ECTO:0000509 ! exposure to drug +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:138015 ! has exposure stimulus endocrine disruptor +relationship: RO:0002309 CHEBI:138015 ! has exposure stimulus endocrine disruptor + +[Term] +id: ECTO:9001655 +name: exposure to cofactor +def: "An exposure to cofactor." [] +synonym: "exposure to cofactor" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:23357 ! has exposure stimulus cofactor +relationship: RO:0002309 CHEBI:23357 ! has exposure stimulus cofactor + +[Term] +id: ECTO:9001687 +name: exposure to micronutrient +def: "An exposure to micronutrient." [] +synonym: "exposure to micronutrient" EXACT [] +is_a: ECTO:9001695 ! exposure to nutrient +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:27027 ! has exposure stimulus micronutrient +relationship: RO:0002309 CHEBI:27027 ! has exposure stimulus micronutrient + +[Term] +id: ECTO:9001695 +name: exposure to nutrient +def: "An exposure to nutrient." [] +synonym: "exposure to nutrient" EXACT [] +is_a: ECTO:9002063 ! exposure to food component +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33284 ! has exposure stimulus nutrient +relationship: RO:0002309 CHEBI:33284 ! has exposure stimulus nutrient + +[Term] +id: ECTO:9001699 +name: exposure to fuel +def: "An exposure to fuel." [] +synonym: "exposure to fuel" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33292 ! has exposure stimulus fuel +relationship: RO:0002309 CHEBI:33292 ! has exposure stimulus fuel + +[Term] +id: ECTO:9001701 +name: exposure to reagent +def: "An exposure to reagent." [] +synonym: "exposure to reagent" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33893 ! has exposure stimulus reagent +relationship: RO:0002309 CHEBI:33893 ! has exposure stimulus reagent + +[Term] +id: ECTO:9001702 +name: exposure to macronutrient +def: "An exposure to macronutrient." [] +synonym: "exposure to macronutrient" EXACT [] +is_a: ECTO:9001695 ! exposure to nutrient +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:33937 ! has exposure stimulus macronutrient +relationship: RO:0002309 CHEBI:33937 ! has exposure stimulus macronutrient + +[Term] +id: ECTO:9001711 +name: exposure to antiinfective agent +def: "An exposure to antiinfective agent." [] +synonym: "exposure to antiinfective agent" EXACT [] +is_a: ECTO:0000509 ! exposure to drug +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35441 ! has exposure stimulus antiinfective agent +relationship: RO:0002309 CHEBI:35441 ! has exposure stimulus antiinfective agent + +[Term] +id: ECTO:9001718 +name: exposure to anti-inflammatory drug +def: "An exposure to anti-inflammatory drug." [] +synonym: "exposure to anti-inflammatory drug" EXACT [] +is_a: ECTO:0000509 ! exposure to drug +is_a: ECTO:9001982 ! exposure to anti-inflammatory agent +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:35472 ! has exposure stimulus anti-inflammatory drug +relationship: RO:0002309 CHEBI:35472 ! has exposure stimulus anti-inflammatory drug + +[Term] +id: ECTO:9001793 +name: exposure to anaesthetic +def: "An exposure to anaesthetic." [] +synonym: "exposure to anaesthetic" EXACT [] +is_a: ECTO:0000509 ! exposure to drug +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:38867 ! has exposure stimulus anaesthetic +relationship: RO:0002309 CHEBI:38867 ! has exposure stimulus anaesthetic + +[Term] +id: ECTO:9001809 +name: exposure to polar solvent +def: "An exposure to polar solvent." [] +synonym: "exposure to polar solvent" EXACT [] +is_a: ECTO:9000107 ! exposure to solvent +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:48354 ! has exposure stimulus polar solvent +relationship: RO:0002309 CHEBI:48354 ! has exposure stimulus polar solvent + +[Term] +id: ECTO:9001811 +name: exposure to protic solvent +def: "An exposure to protic solvent." [] +synonym: "exposure to protic solvent" EXACT [] +is_a: ECTO:0000650 ! exposure to Bronsted acid +is_a: ECTO:9001809 ! exposure to polar solvent +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:48356 ! has exposure stimulus protic solvent +relationship: RO:0002309 CHEBI:48356 ! has exposure stimulus protic solvent + +[Term] +id: ECTO:9001813 +name: exposure to amphiprotic solvent +def: "An exposure to amphiprotic solvent." [] +synonym: "exposure to amphiprotic solvent" EXACT [] +is_a: ECTO:9001811 ! exposure to protic solvent +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:48360 ! has exposure stimulus amphiprotic solvent +relationship: RO:0002309 CHEBI:48360 ! has exposure stimulus amphiprotic solvent + +[Term] +id: ECTO:9001822 +name: exposure to antagonist +def: "An exposure to antagonist." [] +synonym: "exposure to antagonist" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:48706 ! has exposure stimulus antagonist +relationship: RO:0002309 CHEBI:48706 ! has exposure stimulus antagonist + +[Term] +id: ECTO:9001942 +name: exposure to food additive +def: "An exposure to food additive." [] +synonym: "exposure to food additive" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +is_a: ECTO:9002063 ! exposure to food component +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:64047 ! has exposure stimulus food additive +relationship: RO:0002309 CHEBI:64047 ! has exposure stimulus food additive + +[Term] +id: ECTO:9001943 +name: exposure to food acidity regulator +def: "An exposure to food acidity regulator." [] +synonym: "exposure to food acidity regulator" EXACT [] +is_a: ECTO:9001942 ! exposure to food additive +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:64049 ! has exposure stimulus food acidity regulator +relationship: RO:0002309 CHEBI:64049 ! has exposure stimulus food acidity regulator + +[Term] +id: ECTO:9001975 +name: exposure to antimicrobial food preservative +def: "An exposure to antimicrobial food preservative." [] +synonym: "exposure to antimicrobial food preservative" EXACT [] +is_a: ECTO:0000544 ! exposure to antimicrobial agent +is_a: ECTO:9002130 ! exposure to food preservative +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:65256 ! has exposure stimulus antimicrobial food preservative +relationship: RO:0002309 CHEBI:65256 ! has exposure stimulus antimicrobial food preservative + +[Term] +id: ECTO:9001982 +name: exposure to anti-inflammatory agent +def: "An exposure to anti-inflammatory agent." [] +synonym: "exposure to anti-inflammatory agent" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:67079 ! has exposure stimulus anti-inflammatory agent +relationship: RO:0002309 CHEBI:67079 ! has exposure stimulus anti-inflammatory agent + +[Term] +id: ECTO:9002028 +name: exposure to greenhouse gas +def: "An exposure to greenhouse gas." [] +synonym: "exposure to greenhouse gas" EXACT [] +is_a: ECTO:0000487 ! exposure to chemical with chemical role +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:76413 ! has exposure stimulus greenhouse gas +relationship: RO:0002309 CHEBI:76413 ! has exposure stimulus greenhouse gas + +[Term] +id: ECTO:9002059 +name: exposure to food packaging gas +def: "An exposure to food packaging gas." [] +synonym: "exposure to food packaging gas" EXACT [] +is_a: ECTO:9001942 ! exposure to food additive +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:77974 ! has exposure stimulus food packaging gas +relationship: RO:0002309 CHEBI:77974 ! has exposure stimulus food packaging gas + +[Term] +id: ECTO:9002062 +name: exposure to food propellant +def: "An exposure to food propellant." [] +synonym: "exposure to food propellant" EXACT [] +is_a: ECTO:9001942 ! exposure to food additive +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:78017 ! has exposure stimulus food propellant +relationship: RO:0002309 CHEBI:78017 ! has exposure stimulus food propellant + +[Term] +id: ECTO:9002063 +name: exposure to food component +def: "An exposure to food component." [] +synonym: "exposure to food component" EXACT [] +is_a: ECTO:0000485 ! exposure to chemical with biological effect +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:78295 ! has exposure stimulus food component +relationship: RO:0002309 CHEBI:78295 ! has exposure stimulus food component + +[Term] +id: ECTO:9002066 +name: exposure to refrigerant +def: "An exposure to refrigerant." [] +synonym: "exposure to refrigerant" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:78433 ! has exposure stimulus refrigerant +relationship: RO:0002309 CHEBI:78433 ! has exposure stimulus refrigerant + +[Term] +id: ECTO:9002130 +name: exposure to food preservative +def: "An exposure to food preservative." [] +synonym: "exposure to food preservative" EXACT [] +is_a: ECTO:9001942 ! exposure to food additive +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:65255 ! has exposure stimulus food preservative +relationship: RO:0002309 CHEBI:65255 ! has exposure stimulus food preservative + +[Term] +id: ECTO:9002131 +name: exposure to flame retardant +def: "An exposure to flame retardant." [] +synonym: "exposure to flame retardant" EXACT [] +is_a: ECTO:0000486 ! exposure to chemical with application +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:79314 ! has exposure stimulus flame retardant +relationship: RO:0002309 CHEBI:79314 ! has exposure stimulus flame retardant + +[Term] +id: ECTO:9002146 +name: exposure to acids +def: "An exposure to acid." [] +synonym: "exposure to acid" EXACT [] +is_a: ECTO:0000487 ! exposure to chemical with chemical role +intersection_of: ExO:0000002 ! exposure event +intersection_of: RO:0002309 CHEBI:37527 ! has exposure stimulus acid +relationship: RO:0002309 CHEBI:37527 ! has exposure stimulus acid + +[Term] +id: ENVO:00000191 +name: solid astronomical body part +def: "A part of an astronomical body which is primarily composed of a continuous volume of solid material, shaped by one or more environmental processes." [] +synonym: "geological feature" RELATED [] +synonym: "physiographic feature" RELATED [] +is_a: ENVO:01000813 ! astronomical body part +intersection_of: ENVO:01000813 ! astronomical body part +intersection_of: composed_primarily_of ENVO:01000814 ! solid environmental material +relationship: composed_primarily_of ENVO:01000814 ! solid environmental material + +[Term] +id: ENVO:00000428 +name: biome +def: "A biome is an ecosystem to which resident ecological communities have evolved adaptations." [] +synonym: "EcosytemType" RELATED [] +synonym: "major habitat type" EXACT [] +is_a: ENVO:01001110 ! ecosystem +relationship: has_component ENVO:01000739 {minCardinality="2"} ! habitat +relationship: has_part ENVO:01000739 ! habitat +relationship: part_of ENVO:01000817 ! biosphere +relationship: RO:0002507 PCO:0000002 ! determined by ecological community + +[Term] +id: ENVO:00000446 +name: terrestrial biome +def: "A biome which is primarily or completely situated on a landmass." [] +synonym: "terrestrial realm" RELATED [] +is_a: ENVO:00000428 ! biome + +[Term] +id: ENVO:00003074 +name: manufactured product +def: "A material entity that has been processed by humans or their technology in any way, including intermediate products as well as final products." [] +synonym: "manufactured good" EXACT [] +is_a: BFO:0000040 ! material entity +intersection_of: BFO:0000040 ! material entity +intersection_of: output_of ENVO:01000993 ! manufacturing process +relationship: output_of ENVO:01000993 ! manufacturing process + +[Term] +id: ENVO:00010483 +name: environmental material +def: "A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system." [] +synonym: "environmental" BROAD [] +synonym: "portion of environmental material" EXACT [] +is_a: BFO:0000024 ! fiat object part +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl + +[Term] +id: ENVO:00010504 +name: surface layer +def: "A layer of some material entity which is adjacent to one or more of its external boundaries and directly interacts with its immediate surroundings." [] +is_a: ENVO:01001684 ! interface layer + +[Term] +id: ENVO:0010001 +name: anthropogenic environmental material +def: "Anthropogenic material in or on which organisms may live." [] +is_a: ENVO:00010483 ! environmental material + +[Term] +id: ENVO:01000155 +name: organic material +def: "Environmental material derived from living organisms and composed primarily of one or more biomacromolecules." [] +synonym: "biomass" EXACT [] +is_a: ENVO:00010483 ! environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: composed_primarily_of CHEBI:33694 ! biomacromolecule +relationship: composed_primarily_of CHEBI:33694 ! biomacromolecule + +[Term] +id: ENVO:01000219 +name: anthropogenic terrestrial biome +def: "An anthropogenic terrestrial biome is a terrestrial biome which has community structures determined by human activity." [] +synonym: "anthrome" EXACT [] +synonym: "human biome" EXACT [] +is_a: ENVO:00000446 ! terrestrial biome +intersection_of: ENVO:00000446 ! terrestrial biome +intersection_of: RO:0002354 ENVO:01000952 ! formed as result of anthropisation +relationship: RO:0002354 ENVO:01000952 ! formed as result of anthropisation + +[Term] +id: ENVO:01000254 +name: environmental system +def: "A system which has the disposition to environ one or more material entities." [] +synonym: "environment" EXACT [] +is_a: RO:0002577 ! system + +[Term] +id: ENVO:01000256 +name: mineral material +def: "A mineral material is an environmental material which is primarily composed of some substance that is naturally occurring, solid and stable at room temperature, representable by a chemical formula, usually abiogenic, and that has an ordered atomic structure." [] +is_a: ENVO:01000814 ! solid environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: composed_primarily_of CHEBI:46662 ! mineral +relationship: composed_primarily_of CHEBI:46662 ! mineral + +[Term] +id: ENVO:01000267 +name: atmosphere +def: "An atmosphere is a layer of gases surrounding a material body of sufficient mass that is held in place by the gravity of the body." [] +is_a: ENVO:01000543 ! atmospheric layer +relationship: adjacent_to ENVO:01000799 ! astronomical body + +[Term] +id: ENVO:01000281 +name: layer +def: "A layer is a quantity of some material which is spatially continuous, has comparable thickness, and usually covers some surface." [] +is_a: BFO:0000040 ! material entity +relationship: has_quality PATO:0002124 ! laminar + +[Term] +id: ENVO:01000304 +name: high pressure environment +def: "A high pressure environment is an environment in which all material entities are exposed to a high ratio of force per unit area." [] +is_a: ENVO:01000997 ! environmental system determined by a quality +intersection_of: ENVO:01000997 ! environmental system determined by a quality +intersection_of: has_quality PATO:0001576 ! increased pressure +relationship: has_quality PATO:0001576 ! increased pressure + +[Term] +id: ENVO:01000305 +name: high temperature environment +def: "A high temperature environment is an environment in which material entities are exposed to increased levels of heat radiation or which have molecules or atoms moving randomly with increased levels of average kinietic energy." [] +is_a: ENVO:01000997 ! environmental system determined by a quality +intersection_of: ENVO:01000997 ! environmental system determined by a quality +intersection_of: has_quality PATO:0001305 ! increased temperature +relationship: has_quality PATO:0001305 ! increased temperature + +[Term] +id: ENVO:01000309 +name: cold environment +def: "An environment which has a lower temperature than some local or global average." [] +is_a: ENVO:01000254 ! environmental system +intersection_of: ENVO:01000254 ! environmental system +intersection_of: has_quality PATO:0001306 ! decreased temperature +relationship: has_quality PATO:0001306 ! decreased temperature + +[Term] +id: ENVO:01000313 +name: anthropogenic environment +def: "An anthropogenic environment is an environmental system which is the product of human activity." [] +is_a: ENVO:01000254 ! environmental system + +[Term] +id: ENVO:01000314 +name: high osmolarity environment +def: "A high osmolarity environment is an environment in which entities are exposed to high concentrations of solutes." [] +is_a: ENVO:01000997 ! environmental system determined by a quality +intersection_of: ENVO:01000997 ! environmental system determined by a quality +intersection_of: has_quality PATO:0001657 ! increased osmolarity +relationship: has_quality PATO:0001657 ! increased osmolarity + +[Term] +id: ENVO:01000324 +name: planetary surface +def: "A planetary surface is a surface layer where the solid or liquid material of a planet comes into contact with an atmosphere or outer space." [] +is_a: ENVO:01001483 ! surface of an astronomical body +intersection_of: ENVO:01001483 ! surface of an astronomical body +intersection_of: part_of ENVO:01000800 ! planet +relationship: part_of ENVO:01000800 ! planet + +[Term] +id: ENVO:01000355 +name: vegetation layer +def: "A layer which is determined by a form of vegetation." [] +synonym: "forest layer" RELATED [] +synonym: "forest stratum" RELATED [] +synonym: "woodland layer" RELATED [] +synonym: "woodland stratum" RELATED [] +is_a: ENVO:01000281 ! layer +intersection_of: ENVO:01000281 ! layer +intersection_of: composed_primarily_of NCBITaxon:33090 ! Viridiplantae +relationship: composed_primarily_of NCBITaxon:33090 ! Viridiplantae + +[Term] +id: ENVO:01000543 +name: atmospheric layer +def: "A layer that is part of the atmosphere." [] +synonym: "atmospheric layering" RELATED [] +is_a: ENVO:01001678 ! fluid layer +intersection_of: ENVO:01001678 ! fluid layer +intersection_of: part_of ENVO:01000267 ! atmosphere +relationship: composed_primarily_of ENVO:01000797 ! gaseous environmental material +relationship: part_of ENVO:01000267 ! atmosphere + +[Term] +id: ENVO:01000554 +name: hydrocarbon gas +def: "A gas that is primarily composed of hydrocarbon molecules." [] +is_a: ENVO:01000797 ! gaseous environmental material +is_a: ENVO:2000045 ! hydrocarbon-based environmental material +intersection_of: ENVO:01000797 ! gaseous environmental material +intersection_of: composed_primarily_of CHEBI:24632 ! hydrocarbon +intersection_of: has_quality PATO:0001547 ! quality of a gas + +[Term] +id: ENVO:01000635 +name: planetary landmass +def: "A landmass which is part of a planet." [] +synonym: "ground" RELATED [] +synonym: "land" BROAD [] +is_a: ENVO:01000324 ! planetary surface +is_a: ENVO:01001782 ! landmass + +[Term] +id: ENVO:01000637 +name: outer space +def: "Outer space is a hard vacuum containing a low density of particles, predominantly a plasma of hydrogen and helium as well as electromagnetic radiation, magnetic fields, neutrinos, dust and cosmic rays that exists between celestial bodies." [] +synonym: "space" BROAD [] +is_a: ENVO:00010483 ! environmental material + +[Term] +id: ENVO:01000638 +name: planetary crust +def: "A planetary crust is the outermost solid shell of a rocky planet or natural satellite, which is chemically distinct from the underlying mantle." [] +synonym: "crust" BROAD [] +is_a: ENVO:01000639 ! planetary structural layer +relationship: has_quality PATO:0001546 ! quality of a solid + +[Term] +id: ENVO:01000639 +name: planetary structural layer +def: "A planetary structural layer is laminar part of a terrestrial planet or other rocky body large enough to have differentiation by density. Planetary layers have differing physicochemical properties and composition." [] +is_a: ENVO:01000281 ! layer +relationship: part_of ENVO:01000800 ! planet + +[Term] +id: ENVO:01000739 +name: habitat +def: "An environmental system which can sustain and allow the growth of an ecological population." [] +is_a: ENVO:01001110 ! ecosystem +relationship: part_of ENVO:01000817 ! biosphere +relationship: RO:0002507 PCO:0000001 ! determined by population of organisms + +[Term] +id: ENVO:01000797 +name: gaseous environmental material +def: "A material entity which is composed of one or more chemical entities and has neither independent shape nor volume but tends to expand indefinitely." [] +synonym: "gas" NARROW [] +is_a: ENVO:02000140 ! fluid environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: has_quality PATO:0001547 ! quality of a gas +relationship: has_quality PATO:0001547 ! quality of a gas + +[Term] +id: ENVO:01000798 +name: plasma +def: "A material entity which is composed of a volume of unbound positive and negative particles in roughly equal numbers, conducts electricity, and possesses internal magnetic fields." [] +is_a: ENVO:02000140 ! fluid environmental material + +[Term] +id: ENVO:01000799 +name: astronomical body +def: "An object which is naturally occuring, bound together by gravitational or electromagnetic forces, and surrounded by space." [] +synonym: "celestial body" RELATED [] +is_a: ENVO:01000804 ! astronomical object + +[Term] +id: ENVO:01000800 +name: planet +def: "A planet is an astronomical body orbiting a star or stellar remnant that is massive enough to be rounded by its own gravity, is not massive enough to cause thermonuclear fusion, and has cleared its neighbouring region of planetesimals." [] +is_a: ENVO:01000799 ! astronomical body + +[Term] +id: ENVO:01000804 +name: astronomical object +def: "An object which is composed of one or more gravitationally bound structures that are associated with a position in space." [] +synonym: "celestial object" RELATED [] +is_a: BFO:0000030 ! object +relationship: has_part ENVO:01000799 ! astronomical body +relationship: has_quality ENVO:01001164 ! geodiversity +relationship: surrounded_by ENVO:01000637 ! outer space + +[Term] +id: ENVO:01000813 +name: astronomical body part +def: "A material part of an astronomical body." [] +is_a: BFO:0000024 ! fiat object part +relationship: part_of ENVO:01000799 ! astronomical body + +[Term] +id: ENVO:01000814 +name: solid environmental material +def: "An environmental material which is in a solid state." [] +is_a: ENVO:00010483 ! environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: has_quality PATO:0001546 ! quality of a solid +relationship: has_quality PATO:0001546 ! quality of a solid + +[Term] +id: ENVO:01000815 +name: liquid environmental material +def: "An environmental material which is in a liquid state." [] +is_a: ENVO:02000140 ! fluid environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: has_quality PATO:0001548 ! quality of a liquid +relationship: has_quality PATO:0001548 ! quality of a liquid + +[Term] +id: ENVO:01000817 +name: biosphere +def: "A biosphere is a part of an astronomical body which includes, as parts, all the living entities within the gravitational sphere of influence of that body, as well as the non-living and dead entities with which they interact." [] +is_a: ENVO:01001479 ! fluid astronomical body part +is_a: ENVO:01001784 ! compound astronomical body part +relationship: has_part PCO:0000000 ! collection of organisms + +[Term] +id: ENVO:01000951 +name: natural environment +def: "An environmental system in which minimal to no anthropisation has occurred and non-human agents are the primary determinants of the system's dynamics and composition." [] +is_a: ENVO:01000254 ! environmental system + +[Term] +id: ENVO:01000952 +name: anthropisation +def: "A process during which a natural environmental system is altered by human action." [] +synonym: "anthropization" EXACT [] +is_a: ENVO:01001434 ! anthropogenic ecosystem conversion process +intersection_of: ENVO:01001434 ! anthropogenic ecosystem conversion process +intersection_of: has_input ENVO:01000951 ! natural environment +intersection_of: has_output ENVO:01000313 ! anthropogenic environment +relationship: has_input ENVO:01000951 ! natural environment +relationship: has_output ENVO:01000313 ! anthropogenic environment + +[Term] +id: ENVO:01000993 +name: manufacturing process +def: "A planned process during which raw or recycled materials are transformed into products for use or sale using labour and machines, tools, chemical and biological processing, or formulation." [] +is_a: OBI:0000011 ! planned process +intersection_of: OBI:0000011 ! planned process +intersection_of: has_output ENVO:00003074 ! manufactured product +relationship: has_output ENVO:00003074 ! manufactured product +relationship: process_has_causal_agent NCBITaxon:9606 ! Homo sapiens + +[Term] +id: ENVO:01000997 +name: environmental system determined by a quality +def: "An environmental system which is determined by materials bearing roughly homogeneous qualities." [] +is_a: ENVO:01000254 ! environmental system + +[Term] +id: ENVO:01000998 +name: environmental system determined by a material +def: "An environmental system within which an environmental material strongly influences the system's composition and properties." [] +is_a: ENVO:01000254 ! environmental system +intersection_of: ENVO:01000254 ! environmental system +intersection_of: RO:0002507 ENVO:00010483 ! determined by environmental material +relationship: RO:0002507 ENVO:00010483 ! determined by environmental material + +[Term] +id: ENVO:01001000 +name: environmental system determined by an organism +def: "An environmental system which is determined by a living organism." [] +synonym: "host-associated environment" RELATED [] +is_a: ENVO:01001110 ! ecosystem +intersection_of: ENVO:01000254 ! environmental system +intersection_of: RO:0002507 NCBITaxon:131567 ! determined by cellular organisms +relationship: RO:0002507 NCBITaxon:131567 ! determined by cellular organisms + +[Term] +id: ENVO:01001001 +name: plant-associated environment +def: "An environmental system determined by a green plant." [] +synonym: "plant environment" BROAD [] +synonym: "Viridiplantae-associated environment" EXACT [] +is_a: ENVO:01001000 ! environmental system determined by an organism +intersection_of: ENVO:01000254 ! environmental system +intersection_of: RO:0002507 NCBITaxon:33090 ! determined by Viridiplantae +relationship: RO:0002507 NCBITaxon:33090 ! determined by Viridiplantae + +[Term] +id: ENVO:01001002 +name: animal-associated environment +def: "An environmental system determined by an animal." [] +synonym: "animal environment" BROAD [] +synonym: "Metazoan-associated environment" EXACT [] +is_a: ENVO:01001000 ! environmental system determined by an organism +intersection_of: ENVO:01000254 ! environmental system +intersection_of: RO:0002507 NCBITaxon:33208 ! determined by Metazoa +relationship: RO:0002507 NCBITaxon:33208 ! determined by Metazoa + +[Term] +id: ENVO:01001008 +name: meteor +def: "A meteor is any matter- or energy-based entity which is located in the atmosphere of an astronomical body." [] +is_a: BFO:0000030 ! object +intersection_of: BFO:0000030 ! object +intersection_of: located_in ENVO:01000267 ! atmosphere +relationship: located_in ENVO:01000267 ! atmosphere + +[Term] +id: ENVO:01001023 +name: radiation +def: "A process during which energy is emitted or transmitted in the form of waves or particles through space or a material medium." [] +is_a: ENVO:01001852 ! energy transfer process +relationship: has_participant CHEBI:36342 ! subatomic particle +relationship: has_participant ENVO:00010483 ! environmental material + +[Term] +id: ENVO:01001040 +name: saline environment +def: "An environment which is determined by materials which bear significant concentrations of salts." [] +is_a: ENVO:01000314 ! high osmolarity environment +is_a: ENVO:01000998 ! environmental system determined by a material + +[Term] +id: ENVO:01001055 +name: environment associated with an animal part or small animal +def: "An environmental system determined by part of a living or dead animal, or a whole small animal." [] +is_a: ENVO:01001110 ! ecosystem +intersection_of: ENVO:01001110 ! ecosystem +intersection_of: RO:0002507 CARO:0000006 ! determined by material anatomical entity +relationship: RO:0002507 CARO:0000006 ! determined by material anatomical entity + +[Term] +id: ENVO:01001057 +name: environment associated with a plant part or small plant +def: "An environmental system determined by part of a living or dead plant, or a whole small plant." [] +is_a: ENVO:01001110 ! ecosystem + +[Term] +id: ENVO:01001110 +name: ecosystem +def: "An environmental system which includes both living and non-living components." [] +is_a: ENVO:01000254 ! environmental system + +[Term] +id: ENVO:01001122 +name: gas planet +def: "A planet which is primarily composed of hydrogen and helium." [] +is_a: ENVO:01000800 ! planet +is_a: ENVO:01001686 ! mass of environmental material +relationship: composed_primarily_of ENVO:01001155 ! astrogeological gas + +[Term] +id: ENVO:01001147 +name: helium planet +def: "A gas planet which has an atmosphere composed primarily of helium." [] +is_a: ENVO:01001122 ! gas planet + +[Term] +id: ENVO:01001154 +name: volatile astrogeological material +def: "A material which is composed primarily of chemical elements and compounds with relatively low boiling points, equilibrium condensation temperatures below 1300 Kelvin, and which are part of the crust or atmosphere of a moon or planet." [] +synonym: "volatile" RELATED [] +is_a: ENVO:00010483 ! environmental material + +[Term] +id: ENVO:01001155 +name: astrogeological gas +def: "An astrogeological volatile which is composed primarily of chemical compounds with boiling points around those of hydrogen and helium." [] +synonym: "gas" RELATED [] +is_a: ENVO:01001154 ! volatile astrogeological material + +[Term] +id: ENVO:01001164 +name: geodiversity +def: "A quality which inheres in a astronomical body or astronomical body part by virtue of the variation in its material composition, participation in geological processes, and the variation in is land- and hydroforms." [] +is_a: PATO:0001241 ! physical object quality + +[Term] +id: ENVO:01001226 +name: terrestrial natural environment +def: "A natural environment which is located on a land mass." [] +is_a: ENVO:01000951 ! natural environment +intersection_of: ENVO:01000951 ! natural environment +intersection_of: part_of ENVO:01000635 ! planetary landmass +relationship: part_of ENVO:01000635 ! planetary landmass + +[Term] +id: ENVO:01001273 +name: liquid layer +def: "A layer which is primarily composed of some liquid material." [] +is_a: ENVO:01001678 ! fluid layer +intersection_of: ENVO:01001678 ! fluid layer +intersection_of: composed_primarily_of ENVO:01000815 ! liquid environmental material +relationship: composed_primarily_of ENVO:01000815 ! liquid environmental material + +[Term] +id: ENVO:01001275 +name: solid layer +def: "A layer which is primarily composed of some solid material, allowing for non-solid parts such as interstitial pockets of gas or liquid." [] +is_a: ENVO:01000281 ! layer +intersection_of: ENVO:01000281 ! layer +intersection_of: composed_primarily_of ENVO:01000814 ! solid environmental material +relationship: composed_primarily_of ENVO:01000814 ! solid environmental material + +[Term] +id: ENVO:01001310 +name: liquid surface layer +def: "A surface layer which is composed primarily of some liquid." [] +is_a: ENVO:01001273 ! liquid layer +is_a: ENVO:01001673 ! fluid surface layer +intersection_of: ENVO:01001673 ! fluid surface layer +intersection_of: composed_primarily_of ENVO:01000815 ! liquid environmental material + +[Term] +id: ENVO:01001311 +name: solid surface layer +def: "A surface layer which is composed primarily of solid environmental material." [] +is_a: ENVO:00010504 ! surface layer +is_a: ENVO:01001275 ! solid layer +intersection_of: ENVO:00010504 ! surface layer +intersection_of: composed_primarily_of ENVO:01000814 ! solid environmental material + +[Term] +id: ENVO:01001434 +name: anthropogenic ecosystem conversion process +def: "A process during which an ecosystem - natural or anthropised - is changed by the actions of humans." [] +is_a: ENVO:02500027 ! anthropogenic environmental process + +[Term] +id: ENVO:01001477 +name: liquid astronomical body part +def: "A part of an astronomical body which is primarily composed of a continuous volume of liquid material, shaped by one or more environmental processes." [] +is_a: ENVO:01001479 ! fluid astronomical body part +is_a: ENVO:01001784 ! compound astronomical body part +intersection_of: ENVO:01001479 ! fluid astronomical body part +intersection_of: composed_primarily_of ENVO:01000815 ! liquid environmental material +relationship: composed_primarily_of ENVO:01000815 ! liquid environmental material + +[Term] +id: ENVO:01001478 +name: gaseous astronomical body part +def: "A part of an astronomical body which is primarily composed of a continuous volume of gaseous material, shaped by one or more environmental processes." [] +is_a: ENVO:01001479 ! fluid astronomical body part +is_a: ENVO:01001784 ! compound astronomical body part +intersection_of: ENVO:01001479 ! fluid astronomical body part +intersection_of: composed_primarily_of ENVO:01000797 ! gaseous environmental material +relationship: composed_primarily_of ENVO:01000797 ! gaseous environmental material + +[Term] +id: ENVO:01001479 +name: fluid astronomical body part +def: "A part of an astronomical body which is primarily composed of a continuous volume of liquid or gaseous material, shaped by one or more environmental processes." [] +is_a: ENVO:01000813 ! astronomical body part + +[Term] +id: ENVO:01001483 +name: surface of an astronomical body +def: "A surface layer where the solid or liquid material of an astronomical body comes into contact with an atmosphere or outer space." [] +is_a: ENVO:00010504 ! surface layer +intersection_of: ENVO:00010504 ! surface layer +intersection_of: part_of ENVO:01000799 ! astronomical body +relationship: part_of ENVO:01000799 ! astronomical body + +[Term] +id: ENVO:01001645 +name: gaseous part of an atmosphere +def: "That part of an atmosphere which is composed of gaseous material." [] +is_a: ENVO:01001478 ! gaseous astronomical body part +intersection_of: ENVO:01001478 ! gaseous astronomical body part +intersection_of: part_of ENVO:01000267 ! atmosphere +relationship: part_of ENVO:01000267 ! atmosphere + +[Term] +id: ENVO:01001673 +name: fluid surface layer +def: "A surface layer which is composed primarily of some liquid or gas." [] +is_a: ENVO:00010504 ! surface layer +is_a: ENVO:01001677 ! fluid interface layer + +[Term] +id: ENVO:01001677 +name: fluid interface layer +def: "A surface layer which separates two portions of fluid with respect to either 1) a discontinuity of some fluid property or 2) some derivative of one of these properties in a direction normal to the interface." [] +is_a: ENVO:01001678 ! fluid layer +is_a: ENVO:01001684 ! interface layer + +[Term] +id: ENVO:01001678 +name: fluid layer +def: "A layer which is composed primarily of some fluid." [] +is_a: ENVO:01000281 ! layer + +[Term] +id: ENVO:01001683 +name: gaseous surface layer +def: "A fluid surface layer which is composed primarily of some gaseous material." [] +is_a: ENVO:01001673 ! fluid surface layer +intersection_of: ENVO:01001673 ! fluid surface layer +intersection_of: composed_primarily_of ENVO:01000797 ! gaseous environmental material +relationship: composed_primarily_of ENVO:01000797 ! gaseous environmental material + +[Term] +id: ENVO:01001684 +name: interface layer +def: "A layer which separates two portions of environmental material which possess 1) differing compositions, 2) a discontinuity of some property, or 3) some derivative of some property in a direction normal to the interface." [] +is_a: ENVO:01000281 ! layer + +[Term] +id: ENVO:01001686 +name: mass of environmental material +def: "An object which is composed primarily of an environmental material" [] +is_a: BFO:0000030 ! object +intersection_of: BFO:0000030 ! object +intersection_of: composed_primarily_of ENVO:00010483 ! environmental material +relationship: composed_primarily_of ENVO:00010483 ! environmental material + +[Term] +id: ENVO:01001687 +name: mass of solid material +def: "An object which is composed primarily of a solid environmental material" [] +is_a: ENVO:01001686 ! mass of environmental material +intersection_of: ENVO:01001686 ! mass of environmental material +intersection_of: composed_primarily_of ENVO:01000814 ! solid environmental material +relationship: composed_primarily_of ENVO:01000814 ! solid environmental material + +[Term] +id: ENVO:01001688 +name: mass of fluid +def: "An object which is composed primarily of a fluid." [] +synonym: "fluid mass" EXACT [] +is_a: ENVO:01001686 ! mass of environmental material + +[Term] +id: ENVO:01001689 +name: mass of gas +def: "An object which is composed primarily of a gas." [] +synonym: "gaseous mass" EXACT [] +is_a: ENVO:01001688 ! mass of fluid +intersection_of: ENVO:01001688 ! mass of fluid +intersection_of: composed_primarily_of ENVO:01000797 ! gaseous environmental material +relationship: composed_primarily_of ENVO:01000797 ! gaseous environmental material + +[Term] +id: ENVO:01001690 +name: mass of liquid +def: "An object which is composed primarily of a liquid." [] +synonym: "liquid mass" EXACT [] +is_a: ENVO:01001688 ! mass of fluid +intersection_of: ENVO:01001688 ! mass of fluid +intersection_of: composed_primarily_of ENVO:01000815 ! liquid environmental material +relationship: composed_primarily_of ENVO:01000815 ! liquid environmental material + +[Term] +id: ENVO:01001691 +name: mass of compounded environmental materials +def: "An mass of environmental materials which has appreciable quantities of several individual materials, such that the removal of one would convert the mass into a different entity." [] +is_a: ENVO:01001686 ! mass of environmental material +intersection_of: ENVO:01001686 ! mass of environmental material +intersection_of: composed_primarily_of ENVO:00010483 {minCardinality="2"} ! environmental material + +[Term] +id: ENVO:01001781 +name: part of a landmass +def: "A solid astronomical body part which is part of the landmass of that body." [] +is_a: ENVO:00000191 ! solid astronomical body part +intersection_of: ENVO:00000191 ! solid astronomical body part +intersection_of: part_of ENVO:01000635 ! planetary landmass +relationship: part_of ENVO:01000635 ! planetary landmass + +[Term] +id: ENVO:01001782 +name: landmass +def: "A large continuous area of land, either surrounded by sea or contiguous with another landmass." [] +is_a: ENVO:01001785 ! land + +[Term] +id: ENVO:01001784 +name: compound astronomical body part +def: "A part of an astronomical body which is primarily composed of a continuous medium bearing liquid, gaseous, and solid material in varying quantities." [] +is_a: ENVO:01000813 ! astronomical body part + +[Term] +id: ENVO:01001785 +name: land +def: "A surface layer of an astronomical body which is primarily composed of solid material and is not covered by oceans or other bodies of water." [] +is_a: ENVO:01001311 ! solid surface layer +is_a: ENVO:01001483 ! surface of an astronomical body + +[Term] +id: ENVO:01001795 +name: ecosystem process +def: "An environmental process either driven by or primarily impacting the parts or emergent properties of an ecosystem." [] +is_a: ENVO:02500000 ! environmental system process +intersection_of: ENVO:02500000 ! environmental system process +intersection_of: process_has_causal_agent ENVO:01001110 ! ecosystem +relationship: process_has_causal_agent ENVO:01001110 ! ecosystem + +[Term] +id: ENVO:01001814 +name: organic object +def: "An object which is formed as a result of one or more biological processes and is composed primarily of organic material." [] +is_a: ENVO:01001686 ! mass of environmental material +intersection_of: BFO:0000030 ! object +intersection_of: composed_primarily_of ENVO:01000155 ! organic material +intersection_of: RO:0002354 GO:0008150 ! formed as result of biological_process +relationship: composed_primarily_of ENVO:01000155 ! organic material +relationship: RO:0002354 GO:0008150 ! formed as result of biological_process + +[Term] +id: ENVO:01001852 +name: energy transfer process +def: "A process during which one entity loses energy to another entity." [] +is_a: ENVO:02500000 ! environmental system process + +[Term] +id: ENVO:01001865 +name: concentration of carbon dioxide in an atmosphere +def: "The concentration of carbon dioxide when measured in air that is part of an atmosphere." [] +is_a: OBA:0100004 ! chemical entity attribute +is_a: PATO:0000033 ! concentration of + +[Term] +id: ENVO:02000140 +name: fluid environmental material +def: "A liquid or a gas." [] +synonym: "fluid" NARROW [] +is_a: ENVO:00010483 ! environmental material +union_of: ENVO:01000797 ! gaseous environmental material +union_of: ENVO:01000798 ! plasma +union_of: ENVO:01000815 ! liquid environmental material + +[Term] +id: ENVO:02500000 +name: environmental system process +def: "A process in which includes the components of an environmental system as participants." [] +is_a: BFO:0000015 ! process + +[Term] +id: ENVO:02500003 +name: atmospheric process +def: "A process which occurs within an atmosphere." [] +is_a: ENVO:02500000 ! environmental system process +intersection_of: ENVO:02500000 ! environmental system process +intersection_of: occurs_in ENVO:01000267 ! atmosphere +relationship: occurs_in ENVO:01000267 ! atmosphere + +[Term] +id: ENVO:02500026 +name: anthropogenic modulatory intervention process +def: "A process during which humans apply technology to alter the magnitude, duration, rate, or impact of an environmental process." [] +is_a: OBI:0000011 ! planned process +intersection_of: OBI:0000011 ! planned process +intersection_of: process_has_causal_agent NCBITaxon:9606 ! Homo sapiens +intersection_of: regulates ENVO:02500000 ! environmental system process +relationship: process_has_causal_agent NCBITaxon:9606 ! Homo sapiens +relationship: regulates ENVO:02500000 ! environmental system process + +[Term] +id: ENVO:02500027 +name: anthropogenic environmental process +def: "An environmental process which is driven by the action of humans." [] +is_a: ENVO:02500000 ! environmental system process +intersection_of: ENVO:02500000 ! environmental system process +intersection_of: process_has_causal_agent NCBITaxon:9606 ! Homo sapiens +relationship: process_has_causal_agent NCBITaxon:9606 ! Homo sapiens + +[Term] +id: ENVO:09000004 +name: amount of carbon atom in environmental material +def: "The amount of a carbon atom when measured in environmental material." [] +synonym: "environmental material carbon atom amount" EXACT [] +is_a: OBA:0000182 ! nutrient level + +[Term] +id: ENVO:09000007 +name: concentration of carbon atom in environmental material +def: "The concentration of a carbon atom when measured in environmental material." [] +synonym: "environmental material carbon atom concentration" EXACT [] +is_a: OBA:0100004 ! chemical entity attribute +is_a: PATO:0000033 ! concentration of + +[Term] +id: ENVO:09000013 +name: amount of nitrogen atom in environmental material +def: "The amount of a nitrogen atom when measured in environmental material." [] +synonym: "environmental material nitrogen atom amount" EXACT [] +is_a: OBA:0000182 ! nutrient level + +[Term] +id: ENVO:09000016 +name: concentration of nitrogen atom in environmental material +def: "The concentration of a nitrogen atom when measured in environmental material." [] +synonym: "environmental material nitrogen atom concentration" EXACT [] +is_a: OBA:0100004 ! chemical entity attribute +is_a: PATO:0000033 ! concentration of + +[Term] +id: ENVO:09200000 +name: temperature of environmental material +def: "The temperature of some environmental material." [] +synonym: "environmental material temperature" EXACT [] +is_a: PATO:0000146 ! temperature +intersection_of: PATO:0000146 ! temperature +intersection_of: RO:0000052 ENVO:00010483 ! inheres in environmental material +relationship: RO:0000052 ENVO:00010483 ! inheres in environmental material + +[Term] +id: ENVO:09200002 +name: environmental system process quality +def: "The quality of a environmental system process." [] +synonym: "quality of environmental system process" EXACT [] +is_a: PATO:0001236 ! process quality +intersection_of: PATO:0001236 ! process quality +intersection_of: RO:0000052 ENVO:02500000 ! inheres in environmental system process +relationship: RO:0000052 ENVO:02500000 ! inheres in environmental system process + +[Term] +id: ENVO:2000045 +name: hydrocarbon-based environmental material +is_a: ENVO:00010483 ! environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: composed_primarily_of CHEBI:24632 ! hydrocarbon +relationship: bearer_of PATO:0015021 ! combustibility +relationship: composed_primarily_of CHEBI:24632 ! hydrocarbon +relationship: has_role CHEBI:33292 ! fuel + +[Term] +id: ENVO:2100000 +name: anatomical entity environment +def: "An environment which is determined by an anatomical entity." [] +is_a: ENVO:01000254 ! environmental system +intersection_of: ENVO:01000254 ! environmental system +intersection_of: RO:0002509 UBERON:0001062 ! determined by part of anatomical entity +relationship: part_of ENVO:01001000 ! environmental system determined by an organism +relationship: RO:0002509 UBERON:0001062 ! determined by part of anatomical entity + +[Term] +id: ExO:0000000 +name: exposure stressor +def: "An agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure_receptor during an exposure event." [] +relationship: interacts_with ExO:0000001 ! exposure_receptor +relationship: interacts_with_an_exposure_receptor_via ExO:0000002 ! exposure event + +[Term] +id: ExO:0000001 +name: exposure_receptor +def: "An entity (e.g., a human, human population, or a human organ) that interacts with an exposure stressor during an exposure event." [] +relationship: interacts_with ExO:0000000 ! exposure stressor + +[Term] +id: ExO:0000002 +name: exposure event +def: "An interaction between an exposure stressor and an exposure_receptor." [] +is_a: BFO:0000015 ! process +relationship: has_part ExO:0000000 ! exposure stressor +relationship: has_part ExO:0000001 ! exposure_receptor +relationship: interacts_with_an_exposure_receptor_via ExO:0000000 ! exposure stressor +relationship: interacts_with_an_exposure_stressor_via ExO:0000001 ! exposure_receptor + +[Term] +id: FOODON:00001002 +name: food product +def: "Food material for humans and animals which is processed with the intention that it be consumable as a whole or added to other food products." [] +is_a: FOODON:00002403 ! food material + +[Term] +id: FOODON:00001015 +name: plant food product +def: "This class includes food products which are derived from or produced by a plant." [] +is_a: FOODON:00002381 ! food product by organism +intersection_of: FOODON:00002381 ! food product by organism +intersection_of: derives_from PO:0000003 ! whole plant +relationship: derives_from PO:0000003 ! whole plant +property_value: IAO:0000114 IAO:0000428 + +[Term] +id: FOODON:00001053 +name: fermented dairy food product +is_a: FOODON:00001256 ! dairy food product +is_a: FOODON:00001258 ! food (fermented) +intersection_of: FOODON:00001256 ! dairy food product +intersection_of: FOODON:00001258 ! food (fermented) + +[Term] +id: FOODON:00001092 +name: vertebrate animal food product +def: "A food product which is derived from or produced by an animal that has a vertibrae." [] +is_a: FOODON:00002381 ! food product by organism +intersection_of: FOODON:00002381 ! food product by organism +intersection_of: derives_from FOODON:03411297 ! vertebrate animal +relationship: derives_from FOODON:03411297 ! vertebrate animal +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00001094 +name: fermented beverage +comment: SIREN DB annotation:\n* has quality 'liquid' (http://purl.obolibrary.org/obo/FOODON_03430130)\n* formed as a result of 'microbial/enzymatic modification process' (http://purl.obolibrary.org/obo/FOODON_03460119)\n* formed as a result of 'curing or aging process' (http://purl.obolibrary.org/obo/FOODON_03460253)\n +subset: subset_siren +synonym: "alcoholic beverage" EXACT [] +xref: SUBSET_SIREN:F5644 +is_a: FOODON:00001258 ! food (fermented) +is_a: FOODON:03301977 ! beverage food product +intersection_of: FOODON:00001258 ! food (fermented) +intersection_of: FOODON:03301977 ! beverage food product +property_value: http://purl.org/dc/elements/1.1/date 2019-06-11T07:25:19Z xsd:dateTime +property_value: IAO:0000117 "Damion Dooley" xsd:string +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:00001176 +name: invertebrate animal food product +is_a: FOODON:00002381 ! food product by organism +intersection_of: FOODON:00002381 ! food product by organism +intersection_of: derives_from FOODON:00002452 ! invertebrate animal +relationship: derives_from FOODON:00002452 ! invertebrate animal + +[Term] +id: FOODON:00001256 +name: dairy food product +def: "A dairy food product has mammilian milk or a milk component as an ingredient." [] +synonym: "dairy product" EXACT [] +synonym: "milk product" EXACT [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=H0242 +is_a: FOODON:00001092 ! vertebrate animal food product +relationship: derives_from UBERON:0001913 ! milk +relationship: member_of FOODON:03400148 ! milk or milk product (us cfr) +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00001257 +name: milk or milk based food product +is_a: FOODON:00001256 ! dairy food product +property_value: seeAlso https://en.wikipedia.org/wiki/Fat_content_of_milk#/media/File:Milkproducts.svg + +[Term] +id: FOODON:00001258 +name: food (fermented) +is_a: FOODON:00002501 ! multi-component food product +is_a: FOODON:00002645 ! food product by process +relationship: output_of FOODON:00001304 ! food fermentation + +[Term] +id: FOODON:00001304 +name: food fermentation +def: "A fermentation process in which either carbohydrates, proteins or fats are modified through microbial, enzymatic and/or other biological process." [] +is_a: FOODON:03460119 ! microbial/enzymatic modification process +is_a: FOODON:03470107 ! food preservation process +relationship: has_output FOODON:00001258 ! food (fermented) +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00001579 +name: alcoholic beverage +def: "An alcoholic drink (or alcoholic beverage) is a drink that contains ethanol, a type of alcohol produced by fermentation of grains, fruits, or other sources of sugar." [] +xref: SUBSET_SIREN:F10770 +is_a: FOODON:00001094 ! fermented beverage +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "Damion Dooley" xsd:string +property_value: IAO:0000119 https://en.m.wikipedia.org/wiki/Alcoholic_drink xsd:anyURI + +[Term] +id: FOODON:00001958 +name: human milk based food product +is_a: FOODON:00001257 ! milk or milk based food product +is_a: FOODON:03315150 ! mammalian milk product +intersection_of: FOODON:00001257 ! milk or milk based food product +intersection_of: derives_from FOODON:03303918 ! human milk (raw) +relationship: derives_from FOODON:03303918 ! human milk (raw) + +[Term] +id: FOODON:00002373 +name: food product by meal type +def: "A meal type is the name of an eating occasion that may have location, food type, or other customary contextual features. (Damion's 1st draft definition)" [] +is_a: FOODON:00001002 ! food product +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00002381 +name: food product by organism +def: "A food product consisting of food material derived primarily from a single organism." [] +is_a: FOODON:00001002 ! food product +relationship: derives_from FOODON:03411564 ! food product organismal source +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00002403 +name: food material +def: "Any substance that can be consumed by an organism to satisfy nutritional or other health needs, or to provide a social or organoleptic food experience" [] +synonym: "food" EXACT [] +synonym: "foodstuff" EXACT [] +synonym: "nourishment" EXACT [] +synonym: "sustenance" EXACT [] +is_a: ENVO:00010483 ! environmental material +intersection_of: ENVO:00010483 ! environmental material +intersection_of: has_role CHEBI:33290 ! food +relationship: has_role CHEBI:33290 ! food +property_value: IAO:0000412 http://purl.obolibrary.org/obo/envo.owl + +[Term] +id: FOODON:00002451 +name: food transformation process +def: "A process involving the physical transformation of a food source or food product into some derived organic material or food product" [] +is_a: ENVO:02500000 ! environmental system process +relationship: has_output FOODON:00002403 ! food material +property_value: IAO:0000114 "requires discussion" xsd:string +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00002452 +name: invertebrate animal +def: "Invertebrates are animals that neither possess nor develop a vertebral column (commonly known as a backbone or spine), derived from the notochord. This includes all animals apart from the subphylum Vertebrata." [] +synonym: "animal" BROAD [] +is_a: FOODON:00003004 ! animal + +[Term] +id: FOODON:00002501 +name: multi-component food product +def: "A food product consisting of food material derived from ingredients sourced from multiple organisms." [] +comment: The definition of this is being discussed in issue: https://github.com/FoodOntology/foodon/issues/57\n\nNamely, how to characterize the threshold of ingredients that make for multi-component classification? Salt, pepper, spices wouldn't normally make a food multi-component? +is_a: FOODON:00001002 ! food product +relationship: derives_from FOODON:00002381 ! food product by organism +relationship: member_of FOODON:03400139 ! multicomponent meal (us cfr) +property_value: hasSynonym "multi-ingredient" xsd:string +property_value: http://purl.org/dc/elements/1.1/date 2019-01-23T22:40:32Z xsd:dateTime +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00002645 +name: food product by process +def: "A food product organized by the process which it results from." [] +is_a: FOODON:00001002 ! food product +property_value: http://purl.org/dc/elements/1.1/date 2019-05-23T23:02:07Z xsd:dateTime +property_value: IAO:0000117 "Damion Dooley" xsd:string + +[Term] +id: FOODON:00003004 +name: animal +def: "A multicellular eukaryotic heterotrophic organism within the kingdom Animalia." [] +is_a: FOODON:03411564 ! food product organismal source + +[Term] +id: FOODON:00003194 +name: vegetarian food product +def: "A food product not including meat and animal tissue products (such as gelatin or animal-derived rennet)." [] +synonym: "vegetarian food" EXACT [] +is_a: FOODON:00002381 ! food product by organism +property_value: http://purl.org/dc/elements/1.1/date 2019-09-11T21:12:43Z xsd:dateTime +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 http://orcid.org/0000-0002-8844-9165 +property_value: IAO:0000119 https://en.wikipedia.org/wiki/Vegetarian_cuisine xsd:string + +[Term] +id: FOODON:03301977 +name: beverage food product +def: "A liquid prepared for consumption, or a product that can be combined with water or milk to make one." [] +is_a: FOODON:00002373 ! food product by meal type +relationship: member_of FOODON:03400229 ! beverage (us cfr) +property_value: http://purl.org/dc/elements/1.1/date 2019-09-12T00:00:00 xsd:dateTime +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "Damion Dooley" xsd:string +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03303918 +name: human milk (raw) +def: "Breast milk is the milk produced by the breasts (or mammary glands) of a human female to feed a child." [] +comment: SIREN DB annotation:\n* has quality 'liquid, low viscosity, with no visible particles' (http://purl.obolibrary.org/obo/FOODON_03430123)\n* derives from 'milk (mammary secretion)' (http://purl.obolibrary.org/obo/UBERON_0001913)\n +subset: subset_siren +xref: SUBSET_SIREN:F3918 +is_a: FOODON:00001958 ! human milk based food product +is_a: UBERON:0001913 ! milk +intersection_of: UBERON:0001913 ! milk +intersection_of: produced_by NCBITaxon:9606 ! Homo sapiens +relationship: produced_by NCBITaxon:9606 ! Homo sapiens +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000119 https://en.wikipedia.org/wiki/Breast_milk xsd:anyURI +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03315150 +name: mammalian milk product +comment: SIREN DB annotation:\n* derives from 'milk (mammary secretion)' (http://purl.obolibrary.org/obo/UBERON_0001913)\n +subset: subset_siren +xref: SUBSET_SIREN:F15150 +is_a: FOODON:00001256 ! dairy food product +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400139 +name: multicomponent meal (us cfr) +def: "A multiple-component food product typically containing a protein source, a vegetable, and a potato, rice or cereal-based component packaged to be served after heating, either as separate items or courses or mixed as recipe components; see 21 CFR 102.26, 102.28 and 104.47 for nutritional quality guidelines." [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0139 +is_a: FOODON:03400172 ! prepared food product (us cfr) +property_value: hasSynonym "compartmentalized dinner" xsd:string +property_value: hasSynonym "dinner with components separated in serving containers" xsd:string +property_value: hasSynonym "dinner, compartmentalized" xsd:string +property_value: hasSynonym "food packs with separate components" xsd:string +property_value: hasSynonym "heat and serve dinner" xsd:string +property_value: hasSynonym "multiple-course dinner" xsd:string +property_value: hasSynonym "tv dinner" xsd:string +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400148 +name: milk or milk product (us cfr) +def: "Milk in all forms, milk-based beverage, cultured milk product, or milk or milk product analog. Index infant formula under *MEAL REPLACEMENT*." [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0148 +is_a: FOODON:03400164 ! dairy product (us cfr) +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400164 +name: dairy product (us cfr) +def: "Milk, a product derived from milk, or a dairy product analog; includes cheese and frozen dairy desserts. [FDA CFSAN 1995]" [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0164 +is_a: FOODON:03401270 ! U.S. code of federal regulations, title 21 food product type +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400172 +name: prepared food product (us cfr) +def: "Food product that is 1) ready or nearly ready for consumption; 2) usually a composite of several foods or ingredients that often belong to distinct product types; 3) usually formulated, mixed and partially or fully cooked. Prepared foods often undergo several of the processes listed in *F. EXTENT OF HEAT TREATMENT* and *H. TREATMENT APPLIED*; these factors should be carefully considered in indexing. The classification of prepared food products emphasizes consumption characteristics. [FDA CFSAN 1995]" [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0172 +is_a: FOODON:03401270 ! U.S. code of federal regulations, title 21 food product type +property_value: hasSynonym "prepared dish" xsd:string +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400229 +name: beverage (us cfr) +def: "Alcoholic or nonalcoholic beverage; excludes milk and milk-based beverages, fruit juices and fruit juice drinks, and vegetable juices. [FDA CFSAN 1995]" [] +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0229 +is_a: FOODON:03401270 ! U.S. code of federal regulations, title 21 food product type +relationship: has_member FOODON:03301977 ! beverage food product +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400289 +name: USA agency food product type +def: "Food group having common consumption, functional or manufacturing characteristics, e.g. *FRUIT OR VEGETABLE PRODUCT*, *DAIRY PRODUCT*, *CONFECTIONARY*, *PREPARED FOOD PRODUCT*, etc. [FDA CFSAN 1995]" [] +comment: LanguaL curation note: This term is for CLASSIFICATION ONLY; DO NOT USE term in indexing. Use a more precise narrower term. +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0289 +is_a: FOODON:03400361 ! agency food product type +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03400361 +name: agency food product type +def: "An agency food product type is a class of food product defined by an agency or consortium." [] +comment: This class is designed to hold 3rd party food classification schemes which are being mapped to FoodOn classes using the 'has member' relation. The two hierarchies are not melded into a subclass polyhierarchy because of possible logical inconsistencies in the agency schemes. The hierarchies of agency schemes are as true to their agency representation as possible. +xref: http://www.langual.org/langual_thesaurus.asp?termid=A0361 +is_a: FOODON:00002403 ! food material +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string + +[Term] +id: FOODON:03401270 +name: U.S. code of federal regulations, title 21 food product type +def: "Food and Drugs, title 21, Code of Federal Regulations. Original food classification in LanguaL." [] +comment: LanguaL curation note: This term is for CLASSIFICATION ONLY; DO NOT USE term in indexing. Use a more precise narrower term. +xref: http://www.langual.org/langual_thesaurus.asp?termid=A1270 +is_a: FOODON:03400289 ! USA agency food product type +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000412 http://langual.org xsd:string +property_value: seeAlso https://www.ecfr.gov/cgi-bin/text-idx?SID=87f720ce0d0b6c4548f4bbfd1f8e4c3d&mc=true&tpl=/ecfrbrowse/Title21/21chapterI.tpl xsd:anyURI + +[Term] +id: FOODON:03411041 +name: chemical food component +def: "Any chemical or chemical mixture that exists in a food material or was added to a food material." [] +is_a: CHEBI:24431 ! chemical entity +relationship: part_of FOODON:00002403 ! food material + +[Term] +id: FOODON:03411134 +name: mammal +def: "Mammals (from Latin mamma \"breast\") are vertebrate animals constituting the class Mammalia, and characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three middle ear bones." [] +is_a: FOODON:00001092 ! vertebrate animal food product +is_a: FOODON:03411297 ! vertebrate animal + +[Term] +id: FOODON:03411297 +name: vertebrate animal +def: "A vertebrate animal is any species of organism within the subphylum Vertebrata (chordates with backbones). Vertebrates represent the overwhelming majority of the phylum Chordata, with currently about 69,276 species described." [] +synonym: "animal" BROAD [] +is_a: FOODON:00003004 ! animal + +[Term] +id: FOODON:03411564 +name: food product organismal source +def: "This is a hierarchy of organisms, grouped minimally in a combination of taxonomy and consumer-oriented food groups." [] +is_a: OBI:0100026 ! organism + +[Term] +id: FOODON:03412972 +name: food additive +is_a: FOODON:03411041 ! chemical food component + +[Term] +id: FOODON:03420116 +name: part of organism +def: "Anatomical part of the plant or animal from which a food product or its major ingredient is derived." [] +is_a: BFO:0000040 ! material entity + +[Term] +id: FOODON:03420122 +name: nonmeat part of animal +def: "Bone, feathers, shell, skin or trim fat." [] +is_a: FOODON:03420127 ! animal body or body part + +[Term] +id: FOODON:03420127 +name: animal body or body part +def: "Includes carcass meat, organ meat, and nonmeat parts of animals, as well as the whole animal." [] +is_a: FOODON:03420164 ! part of animal + +[Term] +id: FOODON:03420164 +name: part of animal +def: "Anatomical part of an animal; includes eggs and milk that, although separated from the animal, are produced as integral parts and are affected by the animal's food intake and metabolism." [] +is_a: FOODON:03420116 ! part of organism + +[Term] +id: FOODON:03460111 +name: food treatment process +def: "Used to specifically characterize a food product based on the treatment or processes applied to the product or any indexed ingredient. The processes include adding, substituting or removing components or modifying the food or component, e.g., through fermentation." [] +comment: LanguaL curation note: This term is for CLASSIFICATION ONLY; DO NOT USE term in indexing. Use a more precise narrower term. +xref: http://www.langual.org/langual_thesaurus.asp?termid=H0111 +is_a: FOODON:00002451 ! food transformation process + +[Term] +id: FOODON:03460119 +name: microbial/enzymatic modification process +def: "A food modification process by microbial or enzymatic action which results in molecular changes in any food component." [] +comment: LanguaL curation note: If salt, sugar or other food additive is used to aid in the modification process, index it by the appropriate term under *INGREDIENT ADDED*. +xref: http://www.langual.org/langual_thesaurus.asp?termid=H0119 +is_a: FOODON:03460141 ! food modification process +property_value: hasSynonym "fermented, unspecified" xsd:string + +[Term] +id: FOODON:03460141 +name: food modification process +comment: LanguaL curation note: Used when the food product underwent mechanical, chemical or enzymatic modification that has affected the texture, flavor or other characteristic of the product. +xref: http://www.langual.org/langual_thesaurus.asp?termid=H0141 +is_a: FOODON:03460111 ! food treatment process + +[Term] +id: FOODON:03470107 +name: food preservation process +def: "The methods contributing to the prevention or retardation of microbial, enzymatic or oxidative spoilage and thus to the extension of shelf life. Index all methods for which information is available, even if a corresponding descriptor has already been used in *H. TREATMENT APPLIED*. Preservation descriptors refer to the finished food as a whole with these exceptions: (1) if the components of a multi-component food, such as cream pie, are preservation by different methods, index all methods; (2) if chemical preservatives are declared on the label, always index them even if it is known that the preservative was introduced through or is only present in a component or ingredient of the food; and (3) if the preservation method for an ingredient is declared on the label (such as brie cheese made from pasteurized milk) index it. Also use *INGREDIENT preservation by THERMAL PROCESSING* or *INGREDIENT preservation by IRRADIATION* when ingredients have been pasteurized, ultrapasteurized, sterilized or irradiated." [] +comment: LanguaL curation note: This term is for CLASSIFICATION ONLY; DO NOT USE term in indexing. Use a more precise narrower term. +xref: http://www.langual.org/langual_thesaurus.asp?termid=J0107 +is_a: FOODON:00002451 ! food transformation process + [Term] id: GO:0000002 name: mitochondrial genome maintenance @@ -31288,8 +58367,8 @@ def: "The directed movement of transition metal ions into, out of or within a ce synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33515 ! transition element cation -relationship: transports_or_maintains_localization_of CHEBI:33515 ! transition element cation +intersection_of: has_primary_input CHEBI:33515 ! transition element cation +relationship: has_primary_input CHEBI:33515 ! transition element cation [Term] id: GO:0000052 @@ -31376,6 +58455,7 @@ is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0015630 ! microtubule cytoskeleton relationship: results_in_organization_of GO:0015630 ! microtubule cytoskeleton +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23114 xsd:anyURI [Term] id: GO:0000228 @@ -31445,6 +58525,9 @@ synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18154 ! polysaccharide +relationship: has_primary_input CHEBI:18154 ! polysaccharide [Term] id: GO:0000278 @@ -31811,7 +58894,8 @@ name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] synonym: "follicular phase" RELATED [] -is_a: GO:0048608 ! reproductive structure development +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0008585 ! female gonad development [Term] @@ -31840,7 +58924,7 @@ namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [PMID:30010832] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process -is_a: GO:0040007 ! growth +is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage @@ -31855,6 +58939,37 @@ xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development +[Term] +id: GO:0001555 +name: oocyte growth +namespace: biological_process +def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048588 ! developmental cell growth +intersection_of: GO:0040007 ! growth +intersection_of: results_in_growth_of CL:0000023 ! oocyte +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +relationship: part_of GO:0048599 ! oocyte development +relationship: results_in_growth_of CL:0000023 ! oocyte + +[Term] +id: GO:0001556 +name: oocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +xref: Wikipedia:Oocyte_maturation +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000023 ! oocyte +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +relationship: part_of GO:0048599 ! oocyte development +relationship: results_in_maturation_of CL:0000023 ! oocyte + [Term] id: GO:0001558 name: regulation of cell growth @@ -31917,6 +59032,7 @@ namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: has_participant GO:0005874 ! microtubule relationship: results_in_formation_of GO:0097427 ! microtubule bundle [Term] @@ -32028,6 +59144,9 @@ name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0004122 ! genitourinary system +relationship: results_in_development_of UBERON:0004122 ! genitourinary system [Term] id: GO:0001656 @@ -32073,6 +59192,17 @@ xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation +[Term] +id: GO:0001666 +name: response to hypoxia +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [] +synonym: "response to hypoxic stress" EXACT [] +synonym: "response to intermittent hypoxia" NARROW [] +synonym: "response to lowered oxygen tension" EXACT [] +synonym: "response to sustained hypoxia" NARROW [] +is_a: GO:0006950 ! response to stress +is_a: GO:0036293 ! response to decreased oxygen levels + [Term] id: GO:0001667 name: ameboidal-type cell migration @@ -32095,15 +59225,29 @@ xref: Wikipedia:Acrosome is_a: GO:0030141 ! secretory granule [Term] -id: GO:0001672 -name: regulation of chromatin assembly or disassembly -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] -synonym: "regulation of chromatin assembly/disassembly" EXACT [] -is_a: GO:1902275 ! regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0006333 ! chromatin assembly or disassembly -relationship: regulates GO:0006333 ! chromatin assembly or disassembly +id: GO:0001674 +name: female germ cell nucleus +namespace: cellular_component +alt_id: GO:0043080 +def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] +synonym: "female germ-cell nucleus" EXACT [] +is_a: GO:0043073 ! germ cell nucleus +intersection_of: GO:0005634 ! nucleus +intersection_of: part_of CL:0000021 ! female germ cell +relationship: in_taxon NCBITaxon:2759 ! Eukaryota +relationship: part_of CL:0000021 ! female germ cell + +[Term] +id: GO:0001675 +name: acrosome assembly +def: "The formation of the acrosome from the spermatid Golgi." [] +synonym: "acrosome formation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0033363 ! secretory granule organization +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 @@ -32125,6 +59269,17 @@ intersection_of: results_in_assembly_of GO:0044207 ! translation initiation tern relationship: part_of GO:0006413 ! translational initiation relationship: results_in_assembly_of GO:0044207 ! translation initiation ternary complex +[Term] +id: GO:0001678 +name: cellular glucose homeostasis +namespace: biological_process +def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042593 ! glucose homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis +intersection_of: GO:0019725 ! cellular homeostasis +intersection_of: regulates_levels_of CHEBI:17234 ! glucose + [Term] id: GO:0001696 name: gastric acid secretion @@ -32149,6 +59304,8 @@ name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development +relationship: in_taxon NCBITaxon:32525 ! Theria +relationship: only_in_taxon NCBITaxon:32525 ! Theria [Term] id: GO:0001702 @@ -32275,7 +59432,7 @@ id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] -is_a: GO:0001667 ! ameboidal-type cell migration +is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0016477 ! cell migration intersection_of: results_in_movement_of CL:0000333 ! migratory neural crest cell relationship: part_of GO:0014032 ! neural crest cell development @@ -32322,6 +59479,35 @@ intersection_of: results_in_movement_of CL:0000540 ! neuron relationship: part_of GO:0048699 ! generation of neurons relationship: results_in_movement_of CL:0000540 ! neuron +[Term] +id: GO:0001767 +name: establishment of lymphocyte polarity +namespace: biological_process +def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "lymphocyte polarization" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: occurs_in CL:0000542 ! lymphocyte +relationship: occurs_in CL:0000542 ! lymphocyte +relationship: part_of GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0001768 +name: establishment of T cell polarity +namespace: biological_process +def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "establishment of T lymphocyte polarity" EXACT [] +synonym: "establishment of T-cell polarity" EXACT [] +synonym: "establishment of T-lymphocyte polarity" EXACT [] +synonym: "T cell polarization" EXACT [] +synonym: "T lymphocyte polarization" EXACT [] +synonym: "T-cell polarization" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: occurs_in CL:0000084 ! T cell +relationship: occurs_in CL:0000084 ! T cell +relationship: part_of GO:0042110 ! T cell activation + [Term] id: GO:0001773 name: myeloid dendritic cell activation @@ -32660,7 +59846,14 @@ synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:350546 ! serotonin(1+) +intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+) + +[Term] +id: GO:0001821 +name: histamine secretion +def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [] +is_a: GO:0046903 ! secretion +is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 @@ -32687,7 +59880,63 @@ namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0000358 ! blastocyst +relationship: in_taxon NCBITaxon:32525 ! Theria +relationship: only_in_taxon NCBITaxon:32525 ! Theria relationship: part_of GO:0001701 ! in utero embryonic development +relationship: results_in_development_of UBERON:0000358 ! blastocyst + +[Term] +id: GO:0001825 +name: blastocyst formation +namespace: biological_process +def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: results_in_formation_of UBERON:0000358 ! blastocyst +relationship: part_of GO:0001824 ! blastocyst development +relationship: results_in_formation_of UBERON:0000358 ! blastocyst + +[Term] +id: GO:0001826 +name: inner cell mass cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. +is_a: GO:0030154 ! cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell +relationship: part_of GO:0001825 ! blastocyst formation +relationship: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell + +[Term] +id: GO:0001829 +name: trophectodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. +synonym: "trophectoderm cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell +relationship: part_of GO:0001825 ! blastocyst formation +relationship: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell + +[Term] +id: GO:0001831 +name: trophectodermal cellular morphogenesis +namespace: biological_process +def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. +synonym: "trophectoderm cellular morphogenesis" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0048598 ! embryonic morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell +relationship: part_of GO:0001829 ! trophectodermal cell differentiation +relationship: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell [Term] id: GO:0001832 @@ -32696,7 +59945,10 @@ namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth +intersection_of: GO:0040007 ! growth +intersection_of: results_in_growth_of UBERON:0000358 ! blastocyst relationship: part_of GO:0001824 ! blastocyst development +relationship: results_in_growth_of UBERON:0000358 ! blastocyst [Term] id: GO:0001833 @@ -32705,6 +59957,9 @@ namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:2000020 ! inner cell mass cell +relationship: acts_on_population_of CL:2000020 ! inner cell mass cell relationship: part_of GO:0001832 ! blastocyst growth [Term] @@ -32715,6 +59970,9 @@ def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:012402060 comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:1000274 ! trophectodermal cell +relationship: acts_on_population_of CL:1000274 ! trophectodermal cell relationship: part_of GO:0001832 ! blastocyst growth [Term] @@ -32867,7 +60125,10 @@ name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002107 ! liver relationship: part_of GO:0061008 ! hepaticobiliary system development +relationship: results_in_development_of UBERON:0002107 ! liver [Term] id: GO:0001890 @@ -32877,7 +60138,11 @@ def: "The process whose specific outcome is the progression of the placenta over synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048513 ! animal organ development -is_a: GO:0048608 ! reproductive structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001987 ! placenta +relationship: in_taxon NCBITaxon:32525 ! Theria +relationship: only_in_taxon NCBITaxon:32525 ! Theria +relationship: results_in_development_of UBERON:0001987 ! placenta [Term] id: GO:0001892 @@ -32885,10 +60150,12 @@ name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "fetal placenta development" EXACT [GOC:dph] -is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048568 ! embryonic organ development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0007106 ! chorionic villus relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development +relationship: results_in_development_of UBERON:0007106 ! chorionic villus [Term] id: GO:0001894 @@ -33078,6 +60345,53 @@ def: "The inner segment of a vertebrate photoreceptor containing mitochondria, r subset: goslim_pir is_a: GO:0110165 ! cellular anatomical entity +[Term] +id: GO:0001932 +name: regulation of protein phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] +synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0042325 ! regulation of phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006468 ! protein phosphorylation +relationship: regulates GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0001933 +name: negative regulation of protein phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +synonym: "down regulation of protein amino acid phosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "downregulation of protein amino acid phosphorylation" EXACT [] +synonym: "inhibition of protein amino acid phosphorylation" NARROW [] +synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0042326 ! negative regulation of phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation +relationship: negatively_regulates GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0001934 +name: positive regulation of protein phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +synonym: "activation of protein amino acid phosphorylation" NARROW [] +synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +synonym: "stimulation of protein amino acid phosphorylation" NARROW [] +synonym: "up regulation of protein amino acid phosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "upregulation of protein amino acid phosphorylation" EXACT [] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0042327 ! positive regulation of phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006468 ! protein phosphorylation +relationship: positively_regulates GO:0006468 ! protein phosphorylation + [Term] id: GO:0001935 name: endothelial cell proliferation @@ -33199,6 +60513,17 @@ namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0106001 ! intestinal hexose absorption +[Term] +id: GO:0001955 +name: blood vessel maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001981 ! blood vessel +relationship: part_of GO:0001568 ! blood vessel development +relationship: results_in_maturation_of UBERON:0001981 ! blood vessel + [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion @@ -33277,6 +60602,25 @@ synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels +[Term] +id: GO:0001979 +name: regulation of systemic arterial blood pressure by chemoreceptor signaling +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [] +synonym: "chemoreceptor control of blood pressure" RELATED [] +synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [] +synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0002007 +name: detection of hypoxic conditions in blood by chemoreceptor signaling +def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [] +synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +relationship: has_part GO:0003022 ! detection of pH by chemoreceptor signaling +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + [Term] id: GO:0002009 name: morphogenesis of an epithelium @@ -33310,6 +60654,18 @@ synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality +[Term] +id: GO:0002028 +name: regulation of sodium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] +synonym: "regulation of Na+ transport" EXACT [] +synonym: "regulation of sodium transport" EXACT [] +is_a: GO:0010959 ! regulation of metal ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006814 ! sodium ion transport +relationship: regulates GO:0006814 ! sodium ion transport + [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation @@ -33431,6 +60787,39 @@ intersection_of: results_in_development_of CL:0000150 ! glandular epithelial cel relationship: part_of GO:0002067 ! glandular epithelial cell differentiation relationship: results_in_development_of CL:0000150 ! glandular epithelial cell +[Term] +id: GO:0002069 +name: columnar/cuboidal epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0002070 ! epithelial cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell +relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development +relationship: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell + +[Term] +id: GO:0002070 +name: epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000066 ! epithelial cell +relationship: part_of GO:0002064 ! epithelial cell development +relationship: results_in_maturation_of CL:0000066 ! epithelial cell + +[Term] +id: GO:0002071 +name: glandular epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000150 ! glandular epithelial cell +relationship: part_of GO:0002068 ! glandular epithelial cell development +relationship: results_in_maturation_of CL:0000150 ! glandular epithelial cell + [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development @@ -33463,6 +60852,17 @@ intersection_of: GO:0061025 ! membrane fusion intersection_of: part_of GO:0007340 ! acrosome reaction relationship: part_of GO:0007340 ! acrosome reaction +[Term] +id: GO:0002082 +name: regulation of oxidative phosphorylation +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [] +synonym: "OXPHOS" EXACT [] +is_a: GO:1903578 ! regulation of ATP metabolic process +is_a: GO:1903715 ! regulation of aerobic respiration +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006119 ! oxidative phosphorylation +relationship: regulates GO:0006119 ! oxidative phosphorylation + [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation @@ -33601,6 +61001,30 @@ synonym: "somatic diversification of immunoglobulins during immune response" REL is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response +[Term] +id: GO:0002213 +name: defense response to insect +namespace: biological_process +alt_id: GO:0002214 +def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] +synonym: "physiological defense response to insect" EXACT [] +is_a: GO:0006952 ! defense response +intersection_of: GO:0006952 ! defense response +intersection_of: has_input NCBITaxon:50557 ! Insecta +relationship: has_input NCBITaxon:50557 ! Insecta + +[Term] +id: GO:0002215 +name: defense response to nematode +namespace: biological_process +alt_id: GO:0002216 +def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] +synonym: "physiological defense response to nematode" EXACT [] +is_a: GO:0006952 ! defense response +intersection_of: GO:0006952 ! defense response +intersection_of: has_input NCBITaxon:6231 ! Nematoda +relationship: has_input NCBITaxon:6231 ! Nematoda + [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production @@ -33698,6 +61122,14 @@ is_a: GO:0006955 ! immune response relationship: in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +[Term] +id: GO:0002251 +name: organ or tissue specific immune response +namespace: biological_process +def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] +synonym: "immune response in organ or tissue" EXACT [] +is_a: GO:0006955 ! immune response + [Term] id: GO:0002252 name: immune effector process @@ -33973,6 +61405,20 @@ is_a: GO:0042113 ! B cell activation intersection_of: GO:0042113 ! B cell activation intersection_of: part_of GO:0006955 ! immune response +[Term] +id: GO:0002313 +name: mature B cell differentiation involved in immune response +def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [] +synonym: "mature B cell development involved in immune response" RELATED [] +synonym: "mature B cell differentiation during immune response" RELATED [] +synonym: "mature B lymphocyte differentiation during immune response" RELATED [] +synonym: "mature B-cell differentiation during immune response" RELATED [] +synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002312 ! B cell activation involved in immune response +is_a: GO:0002335 ! mature B cell differentiation +intersection_of: GO:0002335 ! mature B cell differentiation +intersection_of: part_of GO:0006955 ! immune response + [Term] id: GO:0002318 name: myeloid progenitor cell differentiation @@ -34019,6 +61465,16 @@ is_a: GO:0030101 ! natural killer cell activation intersection_of: GO:0030101 ! natural killer cell activation intersection_of: part_of GO:0006955 ! immune response +[Term] +id: GO:0002335 +name: mature B cell differentiation +def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [] +synonym: "mature B lymphocyte differentiation" EXACT [] +synonym: "mature B-cell differentiation" EXACT [] +synonym: "mature B-lymphocyte differentiation" EXACT [] +synonym: "mature cell development" RELATED [] +is_a: GO:0030183 ! B cell differentiation + [Term] id: GO:0002339 name: B cell selection @@ -34052,6 +61508,25 @@ is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction +[Term] +id: GO:0002343 +name: peripheral B cell selection +def: "Any B cell selection process that occurs in the periphery." [] +synonym: "peripheral B lymphocyte selection" EXACT [] +synonym: "peripheral B-cell selection" EXACT [] +synonym: "peripheral B-lymphocyte selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002344 +name: B cell affinity maturation +def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [] +synonym: "B lymphocyte affinity maturation" EXACT [] +synonym: "B-cell affinity maturation" EXACT [] +synonym: "B-lymphocyte affinity maturation" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response + [Term] id: GO:0002346 name: B cell positive selection @@ -34062,6 +61537,21 @@ synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection +[Term] +id: GO:0002349 +name: histamine production involved in inflammatory response +def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [] +synonym: "histamine production involved in acute inflammatory response" BROAD [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002351 +name: serotonin production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] +synonym: "serotonin production involved in acute inflammatory response" BROAD [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + [Term] id: GO:0002352 name: B cell negative selection @@ -34198,6 +61688,18 @@ intersection_of: GO:0002377 ! immunoglobulin production intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response relationship: part_of GO:0016064 ! immunoglobulin mediated immune response +[Term] +id: GO:0002384 +name: hepatic immune response +namespace: biological_process +def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002251 ! organ or tissue specific immune response +intersection_of: GO:0006955 ! immune response +intersection_of: occurs_in UBERON:0002107 ! liver +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: occurs_in UBERON:0002107 ! liver +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata + [Term] id: GO:0002396 name: MHC protein complex assembly @@ -34273,6 +61775,29 @@ synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression +[Term] +id: GO:0002441 +name: histamine secretion involved in inflammatory response +def: "The regulated release of histamine by a cell as part of an inflammatory response." [] +synonym: "histamine secretion involved in acute inflammatory response" BROAD [] +is_a: GO:0001821 ! histamine secretion +is_a: GO:0046879 ! hormone secretion +intersection_of: GO:0001821 ! histamine secretion +intersection_of: part_of GO:0006954 ! inflammatory response +relationship: part_of GO:0002349 ! histamine production involved in inflammatory response + +[Term] +id: GO:0002442 +name: serotonin secretion involved in inflammatory response +namespace: biological_process +def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] +synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] +is_a: GO:0001820 ! serotonin secretion +intersection_of: GO:0001820 ! serotonin secretion +intersection_of: part_of GO:0006954 ! inflammatory response +relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response + [Term] id: GO:0002443 name: leukocyte mediated immunity @@ -34403,6 +61928,20 @@ namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response +[Term] +id: GO:0002461 +name: tolerance induction dependent upon immune response +def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [] +synonym: "immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002465 +name: peripheral tolerance induction +def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [] +is_a: GO:0002461 ! tolerance induction dependent upon immune response + [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation @@ -34646,6 +62185,22 @@ is_a: GO:0002532 ! production of molecular mediator involved in inflammatory res intersection_of: GO:0001816 ! cytokine production intersection_of: part_of GO:0006954 ! inflammatory response +[Term] +id: GO:0002538 +name: arachidonic acid metabolite production involved in inflammatory response +def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [] +synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [] +synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] +synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002539 +name: prostaglandin production involved in inflammatory response +def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [] +synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] +is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response + [Term] id: GO:0002548 name: monocyte chemotaxis @@ -34706,6 +62261,12 @@ intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte relationship: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte +[Term] +id: GO:0002574 +name: thrombocyte differentiation +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [] +is_a: GO:0030099 ! myeloid cell differentiation + [Term] id: GO:0002577 name: regulation of antigen processing and presentation @@ -35235,6 +62796,88 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002508 ! central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction +[Term] +id: GO:0002652 +name: regulation of tolerance induction dependent upon immune response +def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [] +synonym: "regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002461 ! tolerance induction dependent upon immune response +relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002653 +name: negative regulation of tolerance induction dependent upon immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [] +synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] +synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response +relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002654 +name: positive regulation of tolerance induction dependent upon immune response +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [] +synonym: "activation of tolerance induction dependent upon immune response" NARROW [] +synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] +synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] +synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response +relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002658 +name: regulation of peripheral tolerance induction +def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [] +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002465 ! peripheral tolerance induction +relationship: regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002659 +name: negative regulation of peripheral tolerance induction +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [] +synonym: "down regulation of peripheral tolerance induction" EXACT [] +synonym: "down-regulation of peripheral tolerance induction" EXACT [] +synonym: "downregulation of peripheral tolerance induction" EXACT [] +synonym: "inhibition of peripheral tolerance induction" NARROW [] +is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002465 ! peripheral tolerance induction +relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002660 +name: positive regulation of peripheral tolerance induction +def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [] +synonym: "activation of peripheral tolerance induction" NARROW [] +synonym: "stimulation of peripheral tolerance induction" NARROW [] +synonym: "up regulation of peripheral tolerance induction" EXACT [] +synonym: "up-regulation of peripheral tolerance induction" EXACT [] +synonym: "upregulation of peripheral tolerance induction" EXACT [] +is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002465 ! peripheral tolerance induction +relationship: positively_regulates GO:0002465 ! peripheral tolerance induction + [Term] id: GO:0002661 name: regulation of B cell tolerance induction @@ -36265,6 +63908,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019730 ! antimicrobial humoral response @@ -36283,6 +63927,7 @@ synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0031349 ! positive regulation of defense response is_a: GO:0032103 ! positive regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019730 ! antimicrobial humoral response @@ -36385,7 +64030,7 @@ def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:16670 ! peptide +intersection_of: has_primary_input CHEBI:16670 ! peptide [Term] id: GO:0002791 @@ -37297,6 +64942,60 @@ def: "A circulatory process that occurs at the level of the vasculature." [GOC:m synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process +[Term] +id: GO:0003020 +name: detection of reduced oxygen by chemoreceptor signaling +def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [] +synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [] +is_a: GO:0070483 ! detection of hypoxia +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling + +[Term] +id: GO:0003022 +name: detection of pH by chemoreceptor signaling +def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [] +synonym: "detection of pH by chemoreceptor signalling" EXACT [] +is_a: GO:0003030 ! detection of hydrogen ion + +[Term] +id: GO:0003027 +name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [] +synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [] +synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [] +synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [] +synonym: "vagal reflex" BROAD [] +is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling + +[Term] +id: GO:0003029 +name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling +def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [] +synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [] +is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling + +[Term] +id: GO:0003030 +name: detection of hydrogen ion +def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003032 +name: detection of oxygen +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0070482 ! response to oxygen levels + +[Term] +id: GO:0003039 +name: detection of reduced oxygen by carotid body chemoreceptor signaling +def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [] +synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [] +is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling + [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure @@ -37316,6 +65015,14 @@ namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure +[Term] +id: GO:0003091 +name: renal water homeostasis +def: "Renal process involved in the maintenance of an internal steady state of water in the body." [] +synonym: "water homeostasis by the renal system" EXACT [] +is_a: GO:0003014 ! renal system process +is_a: GO:0050891 ! multicellular organismal water homeostasis + [Term] id: GO:0003093 name: regulation of glomerular filtration @@ -37334,6 +65041,25 @@ namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] is_a: GO:0097205 ! renal filtration +[Term] +id: GO:0003096 +name: renal sodium ion transport +namespace: biological_process +def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0006814 ! sodium ion transport +intersection_of: GO:0006814 ! sodium ion transport +intersection_of: occurs_in UBERON:0001008 ! renal system +relationship: occurs_in UBERON:0001008 ! renal system + +[Term] +id: GO:0003097 +name: renal water transport +def: "The directed movement of water (H2O) by the renal system." [] +is_a: GO:0003014 ! renal system process +is_a: GO:0006833 ! water transport +relationship: part_of GO:0003091 ! renal water homeostasis + [Term] id: GO:0003104 name: positive regulation of glomerular filtration @@ -37449,6 +65175,19 @@ relationship: results_in_morphogenesis_of UBERON:0004142 ! outflow tract septum created_by: tb creation_date: 2009-09-22T07:51:01Z +[Term] +id: GO:0003149 +name: membranous septum morphogenesis +namespace: biological_process +def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part +relationship: part_of GO:0060412 ! ventricular septum morphogenesis +relationship: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part +created_by: tb +creation_date: 2009-09-22T07:51:41Z + [Term] id: GO:0003150 name: muscular septum morphogenesis @@ -37587,7 +65326,7 @@ def: "The process whose specific outcome is the progression of the sinoatrial (S synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] -is_a: GO:0048738 ! cardiac muscle tissue development +is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0002351 ! sinoatrial node relationship: part_of GO:0003161 ! cardiac conduction system development @@ -37918,10 +65657,11 @@ name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] -is_a: GO:0048856 ! anatomical structure development +is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development -intersection_of: results_in_development_of UBERON:0002302 ! myocardium of atrium -relationship: results_in_development_of UBERON:0002302 ! myocardium of atrium +intersection_of: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium +relationship: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22614 xsd:anyURI created_by: dph creation_date: 2009-10-13T10:53:18Z @@ -38000,6 +65740,44 @@ relationship: results_in_formation_of UBERON:0002063 ! sinus venosus created_by: dph creation_date: 2009-10-13T11:18:34Z +[Term] +id: GO:0003238 +name: conus arteriosus development +namespace: biological_process +def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003983 ! conus arteriosus +relationship: results_in_development_of UBERON:0003983 ! conus arteriosus +created_by: dph +creation_date: 2009-10-13T11:20:57Z + +[Term] +id: GO:0003239 +name: conus arteriosus morphogenesis +namespace: biological_process +def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0003983 ! conus arteriosus +relationship: part_of GO:0003238 ! conus arteriosus development +relationship: results_in_morphogenesis_of UBERON:0003983 ! conus arteriosus +created_by: dph +creation_date: 2009-10-13T11:25:04Z + +[Term] +id: GO:0003240 +name: conus arteriosus formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: results_in_formation_of UBERON:0003983 ! conus arteriosus +relationship: part_of GO:0003239 ! conus arteriosus morphogenesis +relationship: results_in_formation_of UBERON:0003983 ! conus arteriosus +created_by: dph +creation_date: 2009-10-13T11:25:47Z + [Term] id: GO:0003241 name: growth involved in heart morphogenesis @@ -38213,6 +65991,63 @@ relationship: part_of GO:0055017 ! cardiac muscle tissue growth created_by: dph creation_date: 2009-10-22T10:38:10Z +[Term] +id: GO:0003309 +name: type B pancreatic cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] +synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] +synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell +relationship: part_of GO:0031018 ! endocrine pancreas development +relationship: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell +created_by: dph +creation_date: 2009-10-26T09:27:23Z + +[Term] +id: GO:0003310 +name: pancreatic A cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] +synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell +relationship: part_of GO:0031018 ! endocrine pancreas development +relationship: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell +created_by: dph +creation_date: 2009-10-26T09:28:05Z + +[Term] +id: GO:0003311 +name: pancreatic D cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] +synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell +relationship: part_of GO:0031018 ! endocrine pancreas development +relationship: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell +created_by: dph +creation_date: 2009-10-26T09:30:27Z + +[Term] +id: GO:0003312 +name: pancreatic PP cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] +synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell +relationship: part_of GO:0031018 ! endocrine pancreas development +relationship: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell +created_by: dph +creation_date: 2009-10-26T09:32:32Z + [Term] id: GO:0003313 name: heart rudiment development @@ -38257,45 +66092,75 @@ created_by: dph creation_date: 2009-10-27T08:43:37Z [Term] -id: GO:0003330 -name: regulation of extracellular matrix constituent secretion +id: GO:0003322 +name: pancreatic A cell development namespace: biological_process -def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] -is_a: GO:1903053 ! regulation of extracellular matrix organization -is_a: GO:1903530 ! regulation of secretion by cell -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0070278 ! extracellular matrix constituent secretion -relationship: regulates GO:0070278 ! extracellular matrix constituent secretion +def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] +synonym: "pancreatic alpha cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_development_of CL:0000171 ! pancreatic A cell +relationship: part_of GO:0003310 ! pancreatic A cell differentiation +relationship: results_in_development_of CL:0000171 ! pancreatic A cell created_by: dph -creation_date: 2009-11-02T02:07:40Z +creation_date: 2009-11-02T08:13:55Z [Term] -id: GO:0003331 -name: positive regulation of extracellular matrix constituent secretion +id: GO:0003323 +name: type B pancreatic cell development namespace: biological_process -def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] -is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion -is_a: GO:1903055 ! positive regulation of extracellular matrix organization -is_a: GO:1903532 ! positive regulation of secretion by cell -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0070278 ! extracellular matrix constituent secretion -relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion +def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] +synonym: "pancreatic B cell development" EXACT [GOC:mah] +synonym: "pancreatic beta cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_development_of CL:0000169 ! type B pancreatic cell +relationship: part_of GO:0003309 ! type B pancreatic cell differentiation +relationship: results_in_development_of CL:0000169 ! type B pancreatic cell created_by: dph -creation_date: 2009-11-02T02:11:22Z +creation_date: 2009-11-02T08:20:11Z [Term] -id: GO:0003332 -name: negative regulation of extracellular matrix constituent secretion +id: GO:0003324 +name: pancreatic D cell development namespace: biological_process -def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] -is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion -is_a: GO:1903054 ! negative regulation of extracellular matrix organization -is_a: GO:1903531 ! negative regulation of secretion by cell -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion -relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion +def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] +synonym: "pancreatic delta cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_development_of CL:0000173 ! pancreatic D cell +relationship: part_of GO:0003311 ! pancreatic D cell differentiation +relationship: results_in_development_of CL:0000173 ! pancreatic D cell +created_by: dph +creation_date: 2009-11-02T08:23:26Z + +[Term] +id: GO:0003325 +name: pancreatic PP cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0048468 ! cell development +intersection_of: results_in_development_of CL:0002275 ! pancreatic PP cell +relationship: part_of GO:0003312 ! pancreatic PP cell differentiation +relationship: results_in_development_of CL:0002275 ! pancreatic PP cell created_by: dph -creation_date: 2009-11-02T02:13:49Z +creation_date: 2009-11-02T08:25:03Z + +[Term] +id: GO:0003333 +name: amino acid transmembrane transport +namespace: biological_process +def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "amino acid membrane transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 ! amino acid +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: dph +creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003334 @@ -38355,12 +66220,13 @@ synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: GO:0007018 ! microtubule-based movement -intersection_of: GO:0006928 ! movement of cell or subcellular component +intersection_of: GO:0007018 ! microtubule-based movement intersection_of: process_has_causal_agent GO:0005874 ! microtubule intersection_of: results_in_movement_of GO:0005929 ! cilium relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota relationship: results_in_movement_of GO:0005929 ! cilium +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI property_value: RO:0002161 NCBITaxon:3176 property_value: RO:0002161 NCBITaxon:3312 property_value: RO:0002161 NCBITaxon:3378 @@ -38486,6 +66352,54 @@ relationship: results_in_development_of UBERON:0002298 ! brainstem created_by: dph creation_date: 2009-12-03T10:47:20Z +[Term] +id: GO:0003365 +name: establishment of cell polarity involved in ameboidal cell migration +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030010 ! establishment of cell polarity +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: part_of GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0001667 ! ameboidal-type cell migration +created_by: dph +creation_date: 2009-12-08T04:50:41Z + +[Term] +id: GO:0003371 +name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity +intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity +intersection_of: part_of GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration +created_by: dph +creation_date: 2009-12-08T05:42:46Z + +[Term] +id: GO:0003379 +name: establishment of cell polarity involved in gastrulation cell migration +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0042074 ! cell migration involved in gastrulation +created_by: dph +creation_date: 2009-12-09T06:54:44Z + +[Term] +id: GO:0003380 +name: establishment or maintenance of cytoskeleton polarity involved in gastrulation +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity +intersection_of: part_of GO:0007369 ! gastrulation +relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration +created_by: dph +creation_date: 2009-12-09T07:10:57Z + [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation @@ -38619,7 +66533,6 @@ namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics @@ -38649,31 +66562,6 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input CHEBI:33696 ! nucleic acid relationship: has_input CHEBI:33696 ! nucleic acid -[Term] -id: GO:0003677 -name: DNA binding -namespace: molecular_function -alt_id: GO:0043566 -def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] -subset: goslim_agr -subset: goslim_aspergillus -subset: goslim_candida -subset: goslim_chembl -subset: goslim_drosophila -subset: goslim_flybase_ribbon -subset: goslim_generic -subset: goslim_mouse -subset: goslim_plant -subset: goslim_yeast -synonym: "microtubule/chromatin interaction" RELATED [] -synonym: "plasmid binding" NARROW [] -synonym: "structure specific DNA binding" RELATED [] -synonym: "structure-specific DNA binding" RELATED [] -is_a: GO:0003676 ! nucleic acid binding -intersection_of: GO:0005488 ! binding -intersection_of: has_input CHEBI:16991 ! deoxyribonucleic acid -relationship: has_input CHEBI:16991 ! deoxyribonucleic acid - [Term] id: GO:0003682 name: chromatin binding @@ -38694,15 +66582,16 @@ relationship: has_input GO:0000785 ! chromatin [Term] id: GO:0003707 -name: steroid hormone receptor activity +name: nuclear steroid receptor activity namespace: molecular_function def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] -comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. +synonym: "steroid hormone receptor activity" BROAD [] is_a: GO:0038023 ! signaling receptor activity intersection_of: GO:0038023 ! signaling receptor activity intersection_of: has_input CHEBI:26764 ! steroid hormone relationship: has_input CHEBI:26764 ! steroid hormone relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16717 xsd:anyURI [Term] id: GO:0003723 @@ -38712,7 +66601,6 @@ alt_id: GO:0000498 alt_id: GO:0044822 def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -38721,6 +66609,7 @@ subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] @@ -38739,6 +66628,7 @@ def: "Catalysis of a biochemical reaction at physiological temperatures. In biol subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon +subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant @@ -38800,14 +66690,19 @@ is_a: GO:0004104 ! cholinesterase activity id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function +alt_id: GO:0050250 def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] synonym: "aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] +synonym: "retinal oxidase activity" NARROW [] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN +xref: MetaCyc:RXN-8093 +xref: MetaCyc:RXN-8094 xref: Reactome:R-HSA-3204311 "AOX1 oxidises PXL to PDXate" xref: RHEA:16829 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22680 xsd:anyURI [Term] id: GO:0004035 @@ -39216,7 +67111,8 @@ alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 -def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [GOC:curators] +def: "Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators] +def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [] subset: goslim_metagenomics synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" RELATED [] @@ -39255,8 +67151,10 @@ xref: Reactome:R-HSA-6789031 "Membrane-bound myeloperoxidase (MPO) produces hypo xref: Reactome:R-HSA-6789126 "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" xref: Reactome:R-HSA-8855490 "Lactoperoxidase (LPO) produces OSCN-" xref: Reactome:R-HSA-8933635 "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide" +xref: Wikipedia:Peroxidase is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23121 xsd:anyURI [Term] id: GO:0004602 @@ -39423,6 +67321,445 @@ xref: Reactome:R-HSA-71031 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + xref: RHEA:23720 is_a: GO:0016421 ! CoA carboxylase activity +[Term] +id: GO:0004672 +name: protein kinase activity +namespace: molecular_function +alt_id: GO:0050222 +def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] +comment: Note that triphosphate is used as a phosphate donor by at least one kinase. +subset: goslim_candida +synonym: "protamine kinase activity" NARROW [] +xref: MetaCyc:PROTEIN-KINASE-RXN +xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" +xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" +xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" +xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation" +xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004713 +name: protein tyrosine kinase activity +namespace: molecular_function +alt_id: GO:0004718 +def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596] +synonym: "protein-tyrosine kinase activity" EXACT [] +xref: EC:2.7.10.2 {source="skos:narrowMatch"} +xref: Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1" +xref: Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma" +xref: Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation" +xref: Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers" +xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" +xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer" +xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" +xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" +xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" +xref: Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2" +xref: Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5" +xref: Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227" +xref: Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4" +xref: Reactome:R-HSA-1433418 "Phosphorylation of JAK2" +xref: Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs" +xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" +xref: Reactome:R-HSA-1433506 "Phosphorylation of APS" +xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" +xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs" +xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases" +xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" +xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" +xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" +xref: Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes" +xref: Reactome:R-HSA-170991 "SRC-1 autophosphorylates" +xref: Reactome:R-HSA-171011 "Binding and activation of MAP Kinase" +xref: Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15" +xref: Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" +xref: Reactome:R-HSA-177934 "EGFR autophosphorylation" +xref: Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase" +xref: Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)" +xref: Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)" +xref: Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers" +xref: Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1" +xref: Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1" +xref: Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2" +xref: Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions" +xref: Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors" +xref: Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3" +xref: Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4" +xref: Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b" +xref: Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c" +xref: Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b" +xref: Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c" +xref: Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b" +xref: Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c" +xref: Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c" +xref: Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src" +xref: Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers" +xref: Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers" +xref: Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2" +xref: Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1" +xref: Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant" +xref: Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants" +xref: Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant" +xref: Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes" +xref: Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck" +xref: Reactome:R-HSA-202174 "Activation of ZAP-70" +xref: Reactome:R-HSA-202216 "Phosphorylation of SLP-76" +xref: Reactome:R-HSA-202233 "Inactivation of Lck by Csk" +xref: Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT" +xref: Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1" +xref: Reactome:R-HSA-202291 "Activation of Lck" +xref: Reactome:R-HSA-202307 "Change of PKC theta conformation" +xref: Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers" +xref: Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG" +xref: Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases" +xref: Reactome:R-HSA-2029453 "Phosphorylation of VAV" +xref: Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts" +xref: Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants" +xref: Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants" +xref: Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding" +xref: Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding" +xref: Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants" +xref: Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity" +xref: Reactome:R-HSA-205289 "Autophosphorylation of KIT" +xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" +xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" +xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" +xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" +xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP" +xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" +xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK" +xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12" +xref: Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK" +xref: Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK" +xref: Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1" +xref: Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates" +xref: Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK" +xref: Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK" +xref: Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK" +xref: Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4" +xref: Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN" +xref: Reactome:R-HSA-2454239 "Phosphorylation of SYK" +xref: Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR" +xref: Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin" +xref: Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin" +xref: Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin" +xref: Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin" +xref: Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK" +xref: Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK" +xref: Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK" +xref: Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK" +xref: Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN" +xref: Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase" +xref: Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta" +xref: Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn" +xref: Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase" +xref: Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma" +xref: Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F" +xref: Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397" +xref: Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC" +xref: Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex" +xref: Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN" +xref: Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2" +xref: Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn" +xref: Reactome:R-HSA-377640 "Autophosphorylation of SRC" +xref: Reactome:R-HSA-380780 "Activation of Src" +xref: Reactome:R-HSA-388831 "Phosphorylation of CD28" +xref: Reactome:R-HSA-388833 "Phosphorylation of CTLA-4" +xref: Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors" +xref: Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors" +xref: Reactome:R-HSA-389354 "Activation of Vav1" +xref: Reactome:R-HSA-389762 "Phosphorylation of PD-1" +xref: Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha" +xref: Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts" +xref: Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase" +xref: Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn" +xref: Reactome:R-HSA-3928578 "EPH receptors autophosphorylate" +xref: Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs" +xref: Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B" +xref: Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1" +xref: Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3" +xref: Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397" +xref: Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1" +xref: Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF" +xref: Reactome:R-HSA-399934 "Phosphorylation of Plexin-A" +xref: Reactome:R-HSA-399946 "Recruitment and activation of Cdk5" +xref: Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes" +xref: Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2" +xref: Reactome:R-HSA-418163 "Activated Src activates ERK" +xref: Reactome:R-HSA-418859 "Phosphorylation of Unc5C" +xref: Reactome:R-HSA-418872 "Phosphorylation of FADK1" +xref: Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met" +xref: Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase" +xref: Reactome:R-HSA-429441 "SYK activation by SRC" +xref: Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation" +xref: Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8" +xref: Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT" +xref: Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates" +xref: Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1" +xref: Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB" +xref: Reactome:R-HSA-4420206 "Phosphorylation of SRC-1" +xref: Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2" +xref: Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1" +xref: Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC" +xref: Reactome:R-HSA-445085 "Phosphorylation of VAV2" +xref: Reactome:R-HSA-445091 "Phosphorylation of Neurofascin" +xref: Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1" +xref: Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated" +xref: Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated" +xref: Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB" +xref: Reactome:R-HSA-508282 "SYK is a substrate for JAK1" +xref: Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2" +xref: Reactome:R-HSA-5218642 "PTK2 autophosphorylates" +xref: Reactome:R-HSA-5218806 "FYN autophosphorylates" +xref: Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118" +xref: Reactome:R-HSA-5218812 "FYN phosphorylates PAK2" +xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV" +xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1" +xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta" +xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407" +xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814" +xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG" +xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan" +xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG" +xref: Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2" +xref: Reactome:R-HSA-5621370 "SYK autophosphorylates" +xref: Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341" +xref: Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant" +xref: Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII" +xref: Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2" +xref: Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1" +xref: Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2" +xref: Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2" +xref: Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1" +xref: Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c" +xref: Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2" +xref: Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3" +xref: Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1" +xref: Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11" +xref: Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3" +xref: Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11" +xref: Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3" +xref: Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11" +xref: Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1" +xref: Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3" +xref: Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11" +xref: Reactome:R-HSA-5655243 "Activated FGFR3 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655270 "Activated FGFR3 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142" +xref: Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52" +xref: Reactome:R-HSA-5690702 "LYN phosphorylates CD22" +xref: Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2" +xref: Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2" +xref: Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation" +xref: Reactome:R-HSA-6806974 "MET dimers autophosphorylate" +xref: Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK" +xref: Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1" +xref: Reactome:R-HSA-873918 "Transphosphorylation of JAK1" +xref: Reactome:R-HSA-873919 "Phosphorylation of JAK2" +xref: Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases" +xref: Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases" +xref: Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor" +xref: Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2" +xref: Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated" +xref: Reactome:R-HSA-8847977 "FRK phosphorylates PTEN" +xref: Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation" +xref: Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2" +xref: Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3" +xref: Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B" +xref: Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN" +xref: Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1" +xref: Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1" +xref: Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1" +xref: Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL" +xref: Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1" +xref: Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1" +xref: Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2" +xref: Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3" +xref: Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35" +xref: Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6" +xref: Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ" +xref: Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2" +xref: Reactome:R-HSA-8851933 "MET phosphorylates GAB1" +xref: Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions" +xref: Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate" +xref: Reactome:R-HSA-8853315 "Activated FGFR3 fusions phosphorylate FRS2" +xref: Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate" +xref: Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1" +xref: Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB" +xref: Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation" +xref: Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6" +xref: Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307" +xref: Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15" +xref: Reactome:R-HSA-8874078 "PTK2 autophosphorylates" +xref: Reactome:R-HSA-8874080 "SRC phosphorylates PTK2" +xref: Reactome:R-HSA-8874082 "MET phosphorylates PTK2" +xref: Reactome:R-HSA-8875451 "MET phosphorylates CBL" +xref: Reactome:R-HSA-8875817 "MET phosphorylates STAT3" +xref: Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates" +xref: Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL" +xref: Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1" +xref: Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1" +xref: Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3" +xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1" +xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes" +xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18" +xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1" +xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC" +xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC" +xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4" +xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR" +xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin" +xref: Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1" +xref: Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2" +xref: Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3" +xref: Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates" +xref: Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1" +xref: Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1" +xref: Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1" +xref: Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2" +xref: Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1" +xref: Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2" +xref: Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2" +xref: Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1" +xref: Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1" +xref: Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3" +xref: Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates" +xref: Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B" +xref: Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5" +xref: Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation" +xref: Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1" +xref: Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1" +xref: Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2" +xref: Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer" +xref: Reactome:R-HSA-909726 "Phosphorylation of STAT1" +xref: Reactome:R-HSA-909729 "Activation of JAK kinases" +xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" +xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2" +xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" +xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" +xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates" +xref: Reactome:R-HSA-9606159 "BTK autophosphorylates" +xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" +xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" +xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs" +xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" +xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" +xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR" +xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1" +xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK" +xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers" +xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect" +xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate" +xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate" +xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate" +xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3" +xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants" +xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants" +xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants" +xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants" +xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers" +xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins" +xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB" +xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants" +xref: Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants" +xref: Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2" +xref: Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5" +xref: Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B" +xref: Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate" +xref: Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2" +xref: Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10" +xref: Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL" +xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" +xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" +xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" +xref: Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)" +xref: RHEA:10596 {source="skos:exactMatch"} +is_a: GO:0004672 ! protein kinase activity +relationship: part_of GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0004714 +name: transmembrane receptor protein tyrosine kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] +synonym: "receptor protein tyrosine kinase activity" RELATED [EC:2.7.10.1] +synonym: "receptor protein-tyrosine kinase activity" RELATED [EC:2.7.10.1] +xref: EC:2.7.10.1 {source="skos:exactMatch"} +xref: MetaCyc:2.7.10.1-RXN +xref: Reactome:R-HSA-166544 "TrkA receptor autophosphorylates" +xref: Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" +xref: Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" +xref: Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" +xref: Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" +xref: Reactome:R-HSA-198295 "TRKA phosphorylates IRS" +xref: Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" +xref: Reactome:R-HSA-74711 "Phosphorylation of IRS" +xref: Reactome:R-HSA-74715 "Autophosphorylation of insulin receptor" +xref: Reactome:R-HSA-74742 "Phosphorylation of SHC1" +xref: Reactome:R-HSA-8852552 "MST1R autophosphorylates" +xref: Reactome:R-HSA-8853792 "RET tyrosine phosphorylation" +xref: Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" +xref: Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" +xref: Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" +xref: Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" +xref: Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" +xref: Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" +xref: Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" +xref: Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" +xref: Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" +xref: Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" +xref: Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" +xref: Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" +xref: Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" +xref: Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" +xref: Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" +xref: Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" +xref: Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" +xref: Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" +xref: Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" +xref: Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" +xref: Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" +xref: Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" +xref: Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" +xref: Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" +xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" +xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" +xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" +is_a: GO:0004713 ! protein tyrosine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + [Term] id: GO:0004731 name: purine-nucleoside phosphorylase activity @@ -39549,6 +67886,31 @@ xref: MetaCyc:RXN0-901 xref: RHEA:16669 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor +[Term] +id: GO:0004857 +name: enzyme inhibitor activity +namespace: molecular_function +alt_id: GO:0048551 +def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +synonym: "metalloenzyme inhibitor activity" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0003824 ! catalytic activity +relationship: negatively_regulates GO:0003824 ! catalytic activity +relationship: part_of GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0004860 +name: protein kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019210 ! kinase inhibitor activity +is_a: GO:0019887 ! protein kinase regulator activity +intersection_of: GO:0003674 ! molecular_function +intersection_of: negatively_regulates GO:0004672 ! protein kinase activity +relationship: negatively_regulates GO:0004672 ! protein kinase activity + [Term] id: GO:0004888 name: transmembrane signaling receptor activity @@ -39644,6 +68006,23 @@ intersection_of: has_input CHEBI:64628 ! somatostatin relationship: has_input CHEBI:64628 ! somatostatin relationship: part_of GO:0038170 ! somatostatin signaling pathway +[Term] +id: GO:0005009 +name: insulin receptor activity +namespace: molecular_function +def: "Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732] +synonym: "insulin-activated receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +is_a: GO:0016500 ! protein-hormone receptor activity +intersection_of: GO:0038023 ! signaling receptor activity +intersection_of: has_input PR:000009054 ! insulin gene translation product +relationship: has_input PR:000009054 ! insulin gene translation product +relationship: has_part GO:0043559 ! insulin binding +relationship: in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: part_of GO:0008286 ! insulin receptor signaling pathway +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23056 xsd:anyURI + [Term] id: GO:0005102 name: signaling receptor binding @@ -39711,6 +68090,190 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input PR:000002065 ! mast/stem cell growth factor receptor relationship: has_input PR:000002065 ! mast/stem cell growth factor receptor +[Term] +id: GO:0005179 +name: hormone activity +def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [] +synonym: "cAMP generating peptide activity" NARROW [] +synonym: "glycopeptide hormone" NARROW [] +synonym: "lipopeptide hormone" NARROW [] +synonym: "peptide hormone" NARROW [] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0005183 +name: gonadotropin hormone-releasing hormone activity +def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [] +synonym: "GnRH activity" EXACT [] +synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [] +synonym: "LH/FSH-RF" EXACT [] +synonym: "LHRH activity" EXACT [] +synonym: "luteinizing hormone-releasing factor activity" EXACT [] +synonym: "luteinizing hormone-releasing hormone activity" EXACT [] +synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0005215 +name: transporter activity +namespace: molecular_function +alt_id: GO:0005478 +def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] +comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. +subset: gocheck_do_not_annotate +subset: goslim_agr +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: prokaryote_subset +synonym: "carrier" RELATED [] +xref: EC:7.-.-.- +xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" +xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005275 +name: amine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005279 +def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "amine/amide/polyamine channel activity" BROAD [] +synonym: "amine/polyamine transmembrane transporter activity" EXACT [] +synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:32952 ! amine +relationship: has_primary_input CHEBI:32952 ! amine +relationship: part_of GO:0015837 ! amine transport + +[Term] +id: GO:0005277 +name: acetylcholine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" +is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:1901375 ! acetate ester transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:15355 ! acetylcholine +relationship: has_primary_input CHEBI:15355 ! acetylcholine + +[Term] +id: GO:0005310 +name: dicarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005312 +alt_id: GO:0015365 +def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] +synonym: "dicarboxylate carrier" NARROW [] +synonym: "dicarboxylic acid permease activity" RELATED [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" +xref: Reactome:R-HSA-372843 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:35692 ! dicarboxylic acid +relationship: has_primary_input CHEBI:35692 ! dicarboxylic acid +relationship: part_of GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0005319 +name: lipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] +synonym: "apolipoprotein" RELATED [] +synonym: "lipophorin" NARROW [] +xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" +xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" +xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" +xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" +xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" +is_a: GO:0005215 ! transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: has_primary_input CHEBI:18059 ! lipid +relationship: has_primary_input CHEBI:18059 ! lipid +relationship: part_of GO:0006869 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! lipid transport + +[Term] +id: GO:0005326 +name: neurotransmitter transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] +synonym: "neurotransmitter transporter activity" RELATED [] +xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" +xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" +relationship: part_of GO:0006836 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! neurotransmitter transport + +[Term] +id: GO:0005342 +name: organic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:64709 ! organic acid +relationship: has_primary_input CHEBI:64709 ! organic acid +relationship: part_of GO:1903825 ! organic acid transmembrane transport + +[Term] +id: GO:0005355 +name: glucose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015579 +def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] +synonym: "glucose permease activity" EXACT [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" +xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" +is_a: GO:0015149 ! hexose transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:17234 ! glucose +relationship: has_primary_input CHEBI:17234 ! glucose +relationship: part_of GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0005381 +name: iron ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005382 +alt_id: GO:0016033 +alt_id: GO:0097689 +def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] +comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell. +synonym: "iron cation channel activity" EXACT [] +synonym: "iron channel activity" EXACT [] +synonym: "iron transporter activity" EXACT [] +synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] +synonym: "transmembrane iron ion permease activity" EXACT [] +synonym: "transmembrane iron permease activity" EXACT [] +synonym: "zinc, iron permease activity" RELATED [] +xref: Reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region" +xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" +xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24875 ! iron cation +relationship: has_primary_input CHEBI:24875 ! iron cation +relationship: part_of GO:0034755 ! iron ion transmembrane transport +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17162 xsd:anyURI + [Term] id: GO:0005488 name: binding @@ -39754,7 +68317,6 @@ namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Binding to a protein." [GOC:go_curators] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics @@ -39777,6 +68339,16 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input GO:0005581 ! collagen trimer relationship: has_input GO:0005581 ! collagen trimer +[Term] +id: GO:0005536 +name: glucose binding +namespace: molecular_function +def: "Binding to D- or L-enantiomers of glucose." [GOC:jl] +is_a: GO:0048029 ! monosaccharide binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:17234 ! glucose +relationship: has_input CHEBI:17234 ! glucose + [Term] id: GO:0005539 name: glycosaminoglycan binding @@ -39808,7 +68380,6 @@ def: "A location, relative to cellular compartments and structures, occupied by def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics @@ -39829,7 +68400,6 @@ namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon @@ -39839,6 +68409,7 @@ subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity @@ -39873,8 +68444,23 @@ def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:072 is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0098643 ! banded collagen fibril +disjoint_from: GO:0030936 ! transmembrane collagen trimer relationship: part_of GO:0098643 ! banded collagen fibril +[Term] +id: GO:0005584 +name: collagen type I trimer +def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005585 +name: collagen type II trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] +xref: Wikipedia:Collagen_type_II +is_a: GO:0005583 ! fibrillar collagen trimer + [Term] id: GO:0005587 name: collagen type IV trimer @@ -39907,6 +68493,7 @@ comment: Note that for multicellular organisms, the extracellular space refers t subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic +subset: prokaryote_subset synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical entity @@ -39919,7 +68506,6 @@ namespace: cellular_component def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl -subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] @@ -39938,7 +68524,6 @@ name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -39954,6 +68539,7 @@ synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044464 ! obsolete cell part disjoint_from: GO:0005737 ! cytoplasm relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota @@ -39972,6 +68558,16 @@ is_a: GO:0031967 ! organelle envelope relationship: part_of GO:0005634 ! nucleus relationship: part_of GO:0012505 ! endomembrane system +[Term] +id: GO:0005638 +name: lamin filament +def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [] +synonym: "type V intermediate filament" EXACT [] +is_a: GO:0005882 ! intermediate filament +intersection_of: GO:0005882 ! intermediate filament +intersection_of: part_of GO:0005652 ! nuclear lamina +relationship: part_of GO:0005652 ! nuclear lamina + [Term] id: GO:0005640 name: nuclear outer membrane @@ -40010,16 +68606,6 @@ xref: Wikipedia:Nucleoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031981 ! nuclear lumen -[Term] -id: GO:0005677 -name: chromatin silencing complex -namespace: cellular_component -def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] -is_a: GO:0140513 ! nuclear protein-containing complex -intersection_of: GO:0032991 ! protein-containing complex -intersection_of: capable_of_part_of GO:0031507 ! heterochromatin assembly -relationship: capable_of_part_of GO:0031507 ! heterochromatin assembly - [Term] id: GO:0005694 name: chromosome @@ -40027,7 +68613,6 @@ namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40036,6 +68621,7 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] @@ -40047,7 +68633,6 @@ id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40067,14 +68652,15 @@ namespace: cellular_component def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl -subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0099568 ! cytoplasmic region +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23023 xsd:anyURI [Term] id: GO:0005739 @@ -40083,7 +68669,6 @@ namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40165,6 +68750,16 @@ xref: Wikipedia:Mitochondrial_matrix is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0005739 ! mitochondrion +[Term] +id: GO:0005761 +name: mitochondrial ribosome +def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [] +synonym: "55S ribosome, mitochondrial" NARROW [] +is_a: GO:0000313 ! organellar ribosome +intersection_of: GO:0005840 ! ribosome +intersection_of: part_of GO:0005759 ! mitochondrial matrix +relationship: part_of GO:0005759 ! mitochondrial matrix + [Term] id: GO:0005764 name: lysosome @@ -40243,7 +68838,6 @@ name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40295,7 +68889,6 @@ name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40314,7 +68907,6 @@ name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40362,7 +68954,6 @@ namespace: cellular_component def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40421,7 +69012,6 @@ name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila subset: goslim_flybase_ribbon @@ -40439,7 +69029,6 @@ name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic @@ -40447,6 +69036,7 @@ subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] @@ -40462,9 +69052,9 @@ relationship: part_of GO:0000313 ! organellar ribosome id: GO:0005856 name: cytoskeleton namespace: cellular_component -def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] +def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] +def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40474,6 +69064,7 @@ subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle @@ -40554,6 +69145,16 @@ intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm +[Term] +id: GO:0005882 +name: intermediate filament +def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [] +synonym: "intermediate filament associated protein" RELATED [] +synonym: "type I intermediate filament associated protein" RELATED [] +synonym: "type II intermediate filament associated protein" RELATED [] +is_a: GO:0099513 ! polymeric cytoskeletal fiber +relationship: part_of GO:0045111 ! intermediate filament cytoskeleton + [Term] id: GO:0005884 name: actin filament @@ -40573,7 +69174,6 @@ namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40582,6 +69182,7 @@ subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] @@ -40605,6 +69206,20 @@ is_a: GO:0031226 ! intrinsic component of plasma membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005886 ! plasma membrane +[Term] +id: GO:0005899 +name: insulin receptor complex +namespace: cellular_component +def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +is_a: GO:1902911 ! protein kinase complex +intersection_of: GO:0032991 ! protein-containing complex +intersection_of: capable_of GO:0005009 ! insulin receptor activity +relationship: capable_of GO:0005009 ! insulin receptor activity +relationship: in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: part_of GO:0005887 ! integral component of plasma membrane + [Term] id: GO:0005902 name: microvillus @@ -40617,6 +69232,8 @@ xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: has_part GO:0032432 ! actin filament bundle +relationship: part_of CL:0000066 ! epithelial cell +property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0005911 @@ -40694,7 +69311,6 @@ id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] @@ -40721,9 +69337,8 @@ name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 -def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -40733,15 +69348,15 @@ subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "carbohydrate metabolism" EXACT [] -synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] -synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:16646 ! carbohydrate relationship: has_primary_input_or_output CHEBI:16646 ! carbohydrate +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22880 xsd:anyURI created_by: jl creation_date: 2012-10-23T15:40:34Z @@ -40770,6 +69385,40 @@ def: "The chemical reactions and pathways involving glycogen, a polydisperse, hi synonym: "glycogen metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0006112 ! energy reserve metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:28087 ! glycogen +relationship: has_primary_input_or_output CHEBI:28087 ! glycogen + +[Term] +id: GO:0005978 +name: glycogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +synonym: "glycogen anabolism" EXACT [] +synonym: "glycogen biosynthesis" EXACT [] +synonym: "glycogen formation" EXACT [] +synonym: "glycogen synthesis" EXACT [] +xref: MetaCyc:GLYCOGENSYNTH-PWY +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009250 ! glucan biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:28087 ! glycogen +relationship: has_primary_output CHEBI:28087 ! glycogen + +[Term] +id: GO:0005979 +name: regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "regulation of glycogen anabolism" EXACT [] +synonym: "regulation of glycogen biosynthesis" EXACT [] +synonym: "regulation of glycogen formation" EXACT [] +synonym: "regulation of glycogen synthesis" EXACT [] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0005978 ! glycogen biosynthetic process +relationship: regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0005980 @@ -40784,6 +69433,9 @@ xref: MetaCyc:GLYCOCAT-PWY is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:28087 ! glycogen +relationship: has_primary_input CHEBI:28087 ! glycogen [Term] id: GO:0005981 @@ -40808,6 +69460,9 @@ def: "The chemical reactions and pathways involving monosaccharides, the simples synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:35381 ! monosaccharide +relationship: has_primary_input_or_output CHEBI:35381 ! monosaccharide [Term] id: GO:0006000 @@ -40826,6 +69481,23 @@ def: "The chemical reactions and pathways involving glucose, the aldohexose gluc synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:17234 ! glucose +relationship: has_primary_input_or_output CHEBI:17234 ! glucose + +[Term] +id: GO:0006007 +name: glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] +synonym: "glucose breakdown" EXACT [] +synonym: "glucose catabolism" EXACT [] +synonym: "glucose degradation" EXACT [] +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0019320 ! hexose catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:17234 ! glucose +relationship: has_primary_input CHEBI:17234 ! glucose [Term] id: GO:0006012 @@ -40881,6 +69553,36 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18085 ! glycosaminoglycan relationship: has_primary_output CHEBI:18085 ! glycosaminoglycan +[Term] +id: GO:0006026 +name: aminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] +synonym: "aminoglycan breakdown" EXACT [] +synonym: "aminoglycan catabolism" EXACT [] +synonym: "aminoglycan degradation" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:22506 ! aminoglycan +relationship: has_primary_input CHEBI:22506 ! aminoglycan + +[Term] +id: GO:0006027 +name: glycosaminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +synonym: "glycosaminoglycan breakdown" EXACT [] +synonym: "glycosaminoglycan catabolism" EXACT [] +synonym: "glycosaminoglycan degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18085 ! glycosaminoglycan +relationship: has_primary_input CHEBI:18085 ! glycosaminoglycan + [Term] id: GO:0006029 name: proteoglycan metabolic process @@ -40995,6 +69697,7 @@ subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] @@ -41011,6 +69714,9 @@ xref: MetaCyc:GLUCONEO-PWY xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:17234 ! glucose +relationship: has_primary_output CHEBI:17234 ! glucose [Term] id: GO:0006096 @@ -41069,7 +69775,6 @@ synonym: "regulation of glycolysis involved in cellular glucose homeostasis" EXA is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043470 ! regulation of carbohydrate catabolic process -is_a: GO:1900542 ! regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006096 ! glycolytic process @@ -41101,6 +69806,15 @@ subset: goslim_pir synonym: "energy reserve metabolism" EXACT [] is_a: GO:0015980 ! energy derivation by oxidation of organic compounds +[Term] +id: GO:0006119 +name: oxidative phosphorylation +def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [] +synonym: "respiratory-chain phosphorylation" EXACT [] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0046034 ! ATP metabolic process +relationship: has_part GO:0015986 ! proton motive force-driven ATP synthesis + [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process @@ -41185,6 +69899,18 @@ synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process +[Term] +id: GO:0006164 +name: purine nucleotide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [] +synonym: "purine nucleotide anabolism" EXACT [] +synonym: "purine nucleotide biosynthesis" EXACT [] +synonym: "purine nucleotide formation" EXACT [] +synonym: "purine nucleotide synthesis" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation @@ -41213,7 +69939,6 @@ namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon @@ -41224,9 +69949,6 @@ synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process -intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid -relationship: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid [Term] id: GO:0006281 @@ -41238,6 +69960,7 @@ subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! cellular response to DNA damage stimulus @@ -41263,45 +69986,72 @@ subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset is_a: GO:0006259 ! DNA metabolic process -[Term] -id: GO:0006323 -name: DNA packaging -namespace: biological_process -def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] -subset: goslim_pir -synonym: "DNA condensation" EXACT [] -synonym: "DNA organisation" EXACT [] -synonym: "DNA organization" EXACT [] -is_a: GO:0071103 ! DNA conformation change -relationship: has_part GO:0008301 ! DNA binding, bending - [Term] id: GO:0006325 name: chromatin organization namespace: biological_process +alt_id: GO:0006333 +alt_id: GO:0006336 alt_id: GO:0016568 -def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah, GOC:vw, PMID:20404130] +alt_id: GO:0031497 +alt_id: GO:0034724 +def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] subset: goslim_generic subset: goslim_pombe subset: goslim_yeast +synonym: "chromatin assembly" NARROW [] +synonym: "chromatin assembly or disassembly" RELATED [] +synonym: "chromatin assembly/disassembly" RELATED [] +synonym: "chromatin maintenance" BROAD [] synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] +synonym: "DNA replication-independent chromatin assembly" NARROW [] +synonym: "DNA replication-independent chromatin organization" NARROW [] +synonym: "DNA replication-independent nucleosome organisation" NARROW [] +synonym: "DNA replication-independent nuclesome assembly" NARROW [] +synonym: "establishment of chromatin architecture" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] +synonym: "transcription-coupled nucleosome assembly" NARROW [] is_a: GO:0016043 ! cellular component organization -intersection_of: GO:0009987 ! cellular process +intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0000785 ! chromatin -relationship: part_of GO:0051276 ! chromosome organization relationship: results_in_organization_of GO:0000785 ! chromatin +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22130 xsd:anyURI +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23549 xsd:anyURI [Term] -id: GO:0006333 -name: chromatin assembly or disassembly +id: GO:0006338 +name: chromatin remodeling namespace: biological_process -def: "The formation or destruction of chromatin structures." [GOC:mah] -synonym: "chromatin assembly/disassembly" EXACT [] +alt_id: GO:0043044 +def: "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] +synonym: "ATP-dependent chromatin remodeling" NARROW [] +synonym: "ATP-dependent chromatin remodelling" NARROW [] +synonym: "chromatin modeling" EXACT [] +synonym: "chromatin modelling" EXACT [] +synonym: "chromatin remodelling" EXACT [] is_a: GO:0006325 ! chromatin organization +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21732 xsd:anyURI +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21748 xsd:anyURI + +[Term] +id: GO:0006401 +name: RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] +subset: goslim_yeast +synonym: "RNA breakdown" EXACT [] +synonym: "RNA catabolism" EXACT [] +synonym: "RNA degradation" EXACT [] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0034655 ! nucleobase-containing compound catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid +relationship: has_primary_input CHEBI:33697 ! ribonucleic acid [Term] id: GO:0006403 @@ -41321,13 +70071,13 @@ alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant +subset: prokaryote_subset synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [] @@ -41400,7 +70150,7 @@ synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] -is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process @@ -41442,19 +70192,39 @@ relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006464 name: cellular protein modification process -namespace: biological_process -def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] -subset: goslim_aspergillus -subset: goslim_candida -subset: goslim_chembl -subset: goslim_pir -subset: goslim_plant +def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [] synonym: "process resulting in protein modification" RELATED [] -synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] +synonym: "protein modification process" BROAD [] synonym: "protein tagging activity" RELATED [] is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process +[Term] +id: GO:0006468 +name: protein phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group on to a protein." [GOC:hb] +subset: goslim_yeast +synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0036211 ! protein modification process + +[Term] +id: GO:0006469 +name: negative regulation of protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +synonym: "down regulation of protein kinase activity" EXACT [] +synonym: "down-regulation of protein kinase activity" EXACT [] +synonym: "downregulation of protein kinase activity" EXACT [] +synonym: "inhibition of protein kinase activity" NARROW [] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0004672 ! protein kinase activity +relationship: negatively_regulates GO:0004672 ! protein kinase activity + [Term] id: GO:0006486 name: protein glycosylation @@ -41464,6 +70234,7 @@ def: "A protein modification process that results in the addition of a carbohydr subset: goslim_generic subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "protein amino acid glycosylation" EXACT [GOC:bf] synonym: "protein-carbohydrate complex assembly" RELATED [] is_a: GO:0006464 ! cellular protein modification process @@ -41496,6 +70267,22 @@ xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0006486 ! protein glycosylation +[Term] +id: GO:0006516 +name: glycoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +synonym: "glycoprotein breakdown" EXACT [] +synonym: "glycoprotein catabolism" EXACT [] +synonym: "glycoprotein degradation" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:17089 ! glycoprotein +relationship: has_primary_input CHEBI:17089 ! glycoprotein + [Term] id: GO:0006518 name: peptide metabolic process @@ -41515,13 +70302,13 @@ name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "amino acid and derivative metabolism" EXACT [] synonym: "amino acid metabolic process" EXACT [] synonym: "cellular amino acid and derivative metabolic process" EXACT [] @@ -41609,6 +70396,25 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:14321 ! glutamate(1-) relationship: has_primary_output CHEBI:14321 ! glutamate(1-) +[Term] +id: GO:0006538 +name: glutamate catabolic process +namespace: biological_process +alt_id: GO:0019459 +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +synonym: "glutamate breakdown" EXACT [] +synonym: "glutamate catabolism" EXACT [] +synonym: "glutamate deamidation" RELATED [] +synonym: "glutamate degradation" EXACT [] +synonym: "glutamic acid catabolic process" EXACT [] +synonym: "glutamic acid catabolism" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) +relationship: has_primary_input CHEBI:14321 ! glutamate(1-) + [Term] id: GO:0006541 name: glutamine metabolic process @@ -41749,6 +70555,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_drosophila subset: goslim_generic +subset: prokaryote_subset synonym: "amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolic process" EXACT [] synonym: "cellular amino acid derivative metabolism" EXACT [] @@ -41776,6 +70583,21 @@ synonym: "betaine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process +[Term] +id: GO:0006581 +name: acetylcholine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] +synonym: "acetylcholine breakdown" EXACT [] +synonym: "acetylcholine catabolism" EXACT [] +synonym: "acetylcholine degradation" EXACT [] +is_a: GO:0008291 ! acetylcholine metabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:15355 ! acetylcholine +relationship: has_primary_input CHEBI:15355 ! acetylcholine + [Term] id: GO:0006582 name: melanin metabolic process @@ -41812,6 +70634,12 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:38631 ! aminoalkylindole relationship: has_primary_input_or_output CHEBI:38631 ! aminoalkylindole +[Term] +id: GO:0006590 +name: thyroid hormone generation +def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [] +is_a: GO:0042403 ! thyroid hormone metabolic process + [Term] id: GO:0006591 name: ornithine metabolic process @@ -41835,7 +70663,6 @@ name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -41846,6 +70673,7 @@ subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "lipid metabolism" EXACT [] xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process @@ -41953,6 +70781,60 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:35341 ! steroid relationship: has_primary_output CHEBI:35341 ! steroid +[Term] +id: GO:0006699 +name: bile acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid anabolism" EXACT [] +synonym: "bile acid biosynthesis" EXACT [] +synonym: "bile acid formation" EXACT [] +synonym: "bile acid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:36235 ! bile acid anion +relationship: has_primary_output CHEBI:36235 ! bile acid anion + +[Term] +id: GO:0006704 +name: glucocorticoid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [] +synonym: "glucocorticoid anabolism" EXACT [] +synonym: "glucocorticoid biosynthesis" EXACT [] +synonym: "glucocorticoid formation" EXACT [] +synonym: "glucocorticoid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0006705 +name: mineralocorticoid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [] +synonym: "mineralocorticoid anabolism" EXACT [] +synonym: "mineralocorticoid biosynthesis" EXACT [] +synonym: "mineralocorticoid formation" EXACT [] +synonym: "mineralocorticoid synthesis" EXACT [] +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0006706 +name: steroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] +synonym: "steroid breakdown" EXACT [] +synonym: "steroid catabolism" EXACT [] +synonym: "steroid degradation" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:35341 ! steroid +relationship: has_primary_input CHEBI:35341 ! steroid + [Term] id: GO:0006720 name: isoprenoid metabolic process @@ -41988,6 +70870,16 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33655 ! aromatic compound relationship: has_primary_input_or_output CHEBI:33655 ! aromatic compound +[Term] +id: GO:0006749 +name: glutathione metabolic process +def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [] +synonym: "glutathione metabolism" EXACT [] +synonym: "oxidized glutathione reduction" NARROW [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process + [Term] id: GO:0006753 name: nucleoside phosphate metabolic process @@ -41998,6 +70890,19 @@ is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process +[Term] +id: GO:0006754 +name: ATP biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [] +synonym: "ATP anabolism" EXACT [] +synonym: "ATP biosynthesis" EXACT [] +synonym: "ATP formation" EXACT [] +synonym: "ATP regeneration" NARROW [] +synonym: "ATP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046034 ! ATP metabolic process + [Term] id: GO:0006757 name: ATP generation from ADP @@ -42014,7 +70919,6 @@ id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_generic @@ -42097,6 +71001,7 @@ subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe +subset: prokaryote_subset synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] @@ -42162,6 +71067,7 @@ namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 +def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate @@ -42172,10 +71078,12 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant +subset: prokaryote_subset synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0051234 ! establishment of localization +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20292 xsd:anyURI created_by: jl creation_date: 2012-12-13T16:25:32Z @@ -42189,8 +71097,8 @@ subset: goslim_pir subset: goslim_yeast is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:24870 ! ion -relationship: transports_or_maintains_localization_of CHEBI:24870 ! ion +intersection_of: has_primary_input CHEBI:24870 ! ion +relationship: has_primary_input CHEBI:24870 ! ion [Term] id: GO:0006812 @@ -42204,8 +71112,26 @@ synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] synonym: "trivalent inorganic cation transport" NARROW [] is_a: GO:0006811 ! ion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:36916 ! cation -relationship: transports_or_maintains_localization_of CHEBI:36916 ! cation +intersection_of: has_primary_input CHEBI:36916 ! cation +relationship: has_primary_input CHEBI:36916 ! cation + +[Term] +id: GO:0006814 +name: sodium ion transport +namespace: biological_process +alt_id: GO:0006834 +alt_id: GO:0016974 +def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] +synonym: "sodium transport" EXACT [] +synonym: "sodium/potassium transport" BROAD [] +synonym: "sodium:calcium exchange" NARROW [] +synonym: "sodium:solute transport" NARROW [] +is_a: GO:0030001 ! metal ion transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) +relationship: has_primary_input CHEBI:29101 ! sodium(1+) [Term] id: GO:0006817 @@ -42215,8 +71141,8 @@ def: "The directed movement of phosphate into, out of or within a cell, or betwe synonym: "phosphate transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:35780 ! phosphate ion -relationship: transports_or_maintains_localization_of CHEBI:35780 ! phosphate ion +intersection_of: has_primary_input CHEBI:35780 ! phosphate ion +relationship: has_primary_input CHEBI:35780 ! phosphate ion [Term] id: GO:0006820 @@ -42226,8 +71152,8 @@ alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006811 ! ion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:22563 ! anion -relationship: transports_or_maintains_localization_of CHEBI:22563 ! anion +intersection_of: has_primary_input CHEBI:22563 ! anion +relationship: has_primary_input CHEBI:22563 ! anion [Term] id: GO:0006826 @@ -42250,11 +71176,17 @@ synonym: "iron ion import" RELATED [] synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:24875 ! iron cation -relationship: transports_or_maintains_localization_of CHEBI:24875 ! iron cation +intersection_of: has_primary_input CHEBI:24875 ! iron cation +relationship: has_primary_input CHEBI:24875 ! iron cation created_by: pr creation_date: 2012-04-18T03:33:45Z +[Term] +id: GO:0006833 +name: water transport +def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [] +is_a: GO:0042044 ! fluid transport + [Term] id: GO:0006835 name: dicarboxylic acid transport @@ -42264,8 +71196,8 @@ def: "The directed movement of dicarboxylic acids into, out of or within a cell, synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:35693 ! dicarboxylic acid anion -relationship: transports_or_maintains_localization_of CHEBI:35693 ! dicarboxylic acid anion +intersection_of: has_primary_input CHEBI:35693 ! dicarboxylic acid anion +relationship: has_primary_input CHEBI:35693 ! dicarboxylic acid anion [Term] id: GO:0006836 @@ -42284,10 +71216,11 @@ name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0006812 ! cation transport -is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0015844 ! monoamine transport +is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:350546 ! serotonin(1+) -relationship: transports_or_maintains_localization_of CHEBI:350546 ! serotonin(1+) +intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+) +relationship: has_primary_input CHEBI:350546 ! serotonin(1+) [Term] id: GO:0006846 @@ -42296,8 +71229,19 @@ namespace: biological_process def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:30089 ! acetate -relationship: transports_or_maintains_localization_of CHEBI:30089 ! acetate +intersection_of: has_primary_input CHEBI:30089 ! acetate +relationship: has_primary_input CHEBI:30089 ! acetate + +[Term] +id: GO:0006847 +name: plasma membrane acetate transport +namespace: biological_process +def: "The directed movement of acetate across a plasma membrane." [GOC:ai] +is_a: GO:0035433 ! acetate transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:30089 ! acetate +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +relationship: results_in_transport_across GO:0005886 ! plasma membrane [Term] id: GO:0006858 @@ -42309,16 +71253,6 @@ intersection_of: GO:0006810 ! transport intersection_of: occurs_in GO:0005576 ! extracellular region relationship: occurs_in GO:0005576 ! extracellular region -[Term] -id: GO:0006859 -name: extracellular carbohydrate transport -namespace: biological_process -def: "The directed extracellular movement of carbohydrates." [GOC:ai] -is_a: GO:0006858 ! extracellular transport -is_a: GO:0008643 ! carbohydrate transport -intersection_of: GO:0008643 ! carbohydrate transport -intersection_of: occurs_in GO:0005576 ! extracellular region - [Term] id: GO:0006860 name: extracellular amino acid transport @@ -42340,8 +71274,8 @@ subset: goslim_yeast is_a: GO:0015849 ! organic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33709 ! amino acid -relationship: transports_or_maintains_localization_of CHEBI:33709 ! amino acid +intersection_of: has_primary_input CHEBI:33709 ! amino acid +relationship: has_primary_input CHEBI:33709 ! amino acid [Term] id: GO:0006869 @@ -42353,9 +71287,9 @@ subset: goslim_pir subset: goslim_yeast is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:18059 ! lipid +intersection_of: has_primary_input CHEBI:18059 ! lipid +relationship: has_primary_input CHEBI:18059 ! lipid relationship: part_of GO:0010876 ! lipid localization -relationship: transports_or_maintains_localization_of CHEBI:18059 ! lipid [Term] id: GO:0006873 @@ -42400,6 +71334,17 @@ is_a: GO:0055072 ! iron ion homeostasis intersection_of: GO:0055082 ! cellular chemical homeostasis intersection_of: regulates_levels_of CHEBI:24875 ! iron cation +[Term] +id: GO:0006883 +name: cellular sodium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0055078 ! sodium ion homeostasis +intersection_of: GO:0055082 ! cellular chemical homeostasis +intersection_of: regulates_levels_of CHEBI:29101 ! sodium(1+) + [Term] id: GO:0006885 name: regulation of pH @@ -42407,6 +71352,9 @@ namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055067 ! monovalent inorganic cation homeostasis +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates_characteristic PATO:0001842 ! acidity +relationship: regulates_characteristic PATO:0001842 ! acidity [Term] id: GO:0006886 @@ -42415,12 +71363,13 @@ namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: goslim_generic +subset: prokaryote_subset synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein relationship: part_of GO:0034613 ! cellular protein localization [Term] @@ -42583,13 +71532,9 @@ is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006928 name: movement of cell or subcellular component -namespace: biological_process -def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] -comment: Note that in GO cellular components include whole cells (cell is_a cellular component). -subset: gocheck_do_not_annotate -subset: goslim_pir +def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [] synonym: "cell movement" RELATED [] -synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] +synonym: "cellular component motion" EXACT [] synonym: "cellular component movement" EXACT [] is_a: GO:0009987 ! cellular process @@ -42682,7 +71627,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -42721,6 +71665,8 @@ subset: goslim_generic synonym: "inflammation" BROAD [] xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: GO:0006955 @@ -42789,7 +71735,6 @@ name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [] @@ -42809,7 +71754,6 @@ name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_pir @@ -42898,12 +71842,12 @@ id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_yeast +subset: prokaryote_subset synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [] @@ -42913,6 +71857,19 @@ intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005856 ! cytoskeleton relationship: results_in_organization_of GO:0005856 ! cytoskeleton +[Term] +id: GO:0007015 +name: actin filament organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] +synonym: "actin filament organisation" EXACT [] +synonym: "regulation of actin filament localization" NARROW [] +is_a: GO:0097435 ! supramolecular fiber organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0005884 ! actin filament +relationship: part_of GO:0030036 ! actin cytoskeleton organization +relationship: results_in_organization_of GO:0005884 ! actin filament + [Term] id: GO:0007017 name: microtubule-based process @@ -42920,7 +71877,10 @@ namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process -relationship: has_participant GO:0005874 ! microtubule +intersection_of: GO:0009987 ! cellular process +intersection_of: process_has_causal_agent GO:0005874 ! microtubule +relationship: process_has_causal_agent GO:0005874 ! microtubule +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0007018 @@ -42931,9 +71891,6 @@ subset: goslim_drosophila subset: goslim_generic is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process -intersection_of: GO:0006928 ! movement of cell or subcellular component -intersection_of: process_has_causal_agent GO:0005874 ! microtubule -relationship: process_has_causal_agent GO:0005874 ! microtubule [Term] id: GO:0007019 @@ -43062,6 +72019,20 @@ intersection_of: GO:0055074 ! calcium ion homeostasis intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole +[Term] +id: GO:0007039 +name: protein catabolic process in the vacuole +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] +synonym: "vacuolar protein breakdown" RELATED [] +synonym: "vacuolar protein catabolic process" RELATED [] +synonym: "vacuolar protein catabolism" RELATED [] +synonym: "vacuolar protein degradation" RELATED [] +is_a: GO:0030163 ! protein catabolic process +intersection_of: GO:0030163 ! protein catabolic process +intersection_of: occurs_in GO:0005773 ! vacuole +relationship: occurs_in GO:0005773 ! vacuole + [Term] id: GO:0007040 name: lysosome organization @@ -43104,7 +72075,6 @@ namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon @@ -43124,6 +72094,7 @@ subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation @@ -43184,7 +72155,6 @@ name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] -subset: goslim_aspergillus synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] @@ -43199,7 +72169,7 @@ is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport -intersection_of: transports_or_maintains_localization_of GO:0005634 ! nucleus +intersection_of: has_primary_input GO:0005634 ! nucleus [Term] id: GO:0007113 @@ -43211,6 +72181,14 @@ synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle +[Term] +id: GO:0007135 +name: meiosis II +def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [] +synonym: "meiosis II nuclear division" EXACT [] +is_a: GO:0061983 ! meiosis II cell cycle process +is_a: GO:0140013 ! meiotic nuclear division + [Term] id: GO:0007140 name: male meiotic nuclear division @@ -43226,6 +72204,17 @@ intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0048232 ! male gamete generation property_value: RO:0002161 NCBITaxon:4751 +[Term] +id: GO:0007142 +name: male meiosis II +def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [] +synonym: "male meiosis II nuclear division" EXACT [] +is_a: GO:0007135 ! meiosis II +is_a: GO:0007140 ! male meiotic nuclear division +intersection_of: GO:0007135 ! meiosis II +intersection_of: part_of GO:0048232 ! male gamete generation +intersection_of: part_of GO:0051321 ! meiotic cell cycle + [Term] id: GO:0007143 name: female meiotic nuclear division @@ -43242,6 +72231,17 @@ intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0007292 ! female gamete generation property_value: RO:0002161 NCBITaxon:4751 +[Term] +id: GO:0007147 +name: female meiosis II +def: "The cell cycle process in which the second meiotic division occurs in the female germline." [] +synonym: "female meiosis II nuclear division" EXACT [] +is_a: GO:0007135 ! meiosis II +is_a: GO:0007143 ! female meiotic nuclear division +intersection_of: GO:0007135 ! meiosis II +intersection_of: part_of GO:0007292 ! female gamete generation +intersection_of: part_of GO:0051321 ! meiotic cell cycle + [Term] id: GO:0007154 name: cell communication @@ -43258,7 +72258,6 @@ name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -43266,11 +72265,11 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe +subset: prokaryote_subset synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process -is_a: GO:0022610 ! biological adhesion created_by: dos creation_date: 2014-04-15T15:59:10Z @@ -43306,6 +72305,22 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007155 ! cell adhesion relationship: negatively_regulates GO:0007155 ! cell adhesion +[Term] +id: GO:0007163 +name: establishment or maintenance of cell polarity +namespace: biological_process +alt_id: GO:0030012 +alt_id: GO:0030467 +def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +subset: prokaryote_subset +synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] +synonym: "establishment and/or maintenance of cell polarity" RELATED [] +synonym: "establishment and/or maintenance of cell polarization" RELATED [] +is_a: GO:0009987 ! cellular process + [Term] id: GO:0007165 name: signal transduction @@ -43317,7 +72332,6 @@ alt_id: GO:0023033 alt_id: GO:0023045 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics @@ -43341,19 +72355,47 @@ relationship: part_of GO:0051716 ! cellular response to stimulus id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] +def: "The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] subset: goslim_drosophila synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction +[Term] +id: GO:0007167 +name: enzyme-linked receptor protein signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] +synonym: "enzyme linked receptor protein signaling pathway" EXACT [] +synonym: "enzyme linked receptor protein signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007169 +name: transmembrane receptor protein tyrosine kinase signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] +synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme-linked receptor protein signaling pathway + +[Term] +id: GO:0007171 +name: activation of transmembrane receptor protein tyrosine kinase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] +is_a: GO:0032147 ! activation of protein kinase activity +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0038042 -def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] +def: "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] subset: goslim_drosophila synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] @@ -43387,7 +72429,7 @@ relationship: starts_with GO:0099589 ! serotonin receptor activity id: GO:0007213 name: G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process -def: "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] +def: "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] @@ -43401,7 +72443,7 @@ relationship: starts_with GO:0016907 ! G protein-coupled acetylcholine receptor id: GO:0007215 name: glutamate receptor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] +def: "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "glutamate signaling pathway" EXACT [GOC:bf] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway @@ -43413,7 +72455,7 @@ relationship: starts_with GO:0008066 ! glutamate receptor activity id: GO:0007216 name: G protein-coupled glutamate receptor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] +def: "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] @@ -43427,7 +72469,7 @@ relationship: starts_with GO:0098988 ! G protein-coupled glutamate receptor acti id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process -def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] +def: "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway property_value: RO:0002161 NCBITaxon:4751 @@ -43563,6 +72605,24 @@ xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation +[Term] +id: GO:0007288 +name: sperm axoneme assembly +def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0035082 ! axoneme assembly +relationship: part_of GO:0120316 ! sperm flagellum assembly + +[Term] +id: GO:0007289 +name: spermatid nucleus differentiation +def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [] +synonym: "spermatid nuclear differentiation" EXACT [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007286 ! spermatid development + [Term] id: GO:0007292 name: female gamete generation @@ -43570,6 +72630,32 @@ namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation +[Term] +id: GO:0007293 +name: germarium-derived egg chamber formation +namespace: biological_process +def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: in_taxon NCBITaxon:6656 ! Arthropoda +relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007308 +name: oocyte construction +namespace: biological_process +alt_id: GO:0048110 +def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] +synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_formation_of CL:0000023 ! oocyte +relationship: part_of GO:0048599 ! oocyte development +relationship: results_in_formation_of CL:0000023 ! oocyte + [Term] id: GO:0007320 name: insemination @@ -43589,6 +72675,8 @@ def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_ synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] is_a: GO:0009566 ! fertilization +relationship: in_taxon NCBITaxon:2759 ! Eukaryota +relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota property_value: RO:0002161 NCBITaxon:58024 [Term] @@ -43601,6 +72689,19 @@ xref: Wikipedia:Acrosome_reaction is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization +[Term] +id: GO:0007343 +name: egg activation +namespace: biological_process +def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] +xref: Wikipedia:Egg_activation +is_a: GO:0001775 ! cell activation +is_a: GO:0022414 ! reproductive process +intersection_of: GO:0001775 ! cell activation +intersection_of: has_input CL:0000025 ! egg cell +relationship: has_input CL:0000025 ! egg cell +relationship: part_of GO:0007338 ! single fertilization + [Term] id: GO:0007346 name: regulation of mitotic cell cycle @@ -43843,6 +72944,18 @@ intersection_of: results_in_morphogenesis_of UBERON:0001041 ! foregut relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: results_in_morphogenesis_of UBERON:0001041 ! foregut +[Term] +id: GO:0007442 +name: hindgut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0001046 ! hindgut +relationship: part_of GO:0048546 ! digestive tract morphogenesis +relationship: part_of GO:0061525 ! hindgut development +relationship: results_in_morphogenesis_of UBERON:0001046 ! hindgut + [Term] id: GO:0007492 name: endoderm development @@ -43853,6 +72966,16 @@ intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000925 ! endoderm relationship: results_in_development_of UBERON:0000925 ! endoderm +[Term] +id: GO:0007494 +name: midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] +is_a: GO:0048565 ! digestive tract development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001045 ! midgut +relationship: results_in_development_of UBERON:0001045 ! midgut + [Term] id: GO:0007498 name: mesoderm development @@ -43869,8 +72992,8 @@ id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] +is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007498 ! mesoderm development -is_a: GO:0048608 ! reproductive structure development is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0003855 ! gonad mesenchyme @@ -43964,6 +73087,8 @@ synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process +relationship: in_taxon NCBITaxon:40674 ! Mammalia +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia [Term] id: GO:0007566 @@ -43998,15 +73123,6 @@ synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process -[Term] -id: GO:0007569 -name: cell aging -namespace: biological_process -def: "An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators] -synonym: "cell ageing" EXACT [] -is_a: GO:0007568 ! aging -is_a: GO:0048869 ! cellular developmental process - [Term] id: GO:0007585 name: respiratory gaseous exchange by respiratory system @@ -44161,6 +73277,7 @@ synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior +is_a: GO:0032501 ! multicellular organismal process is_a: GO:0050896 ! response to stimulus disjoint_from: GO:0032502 ! developmental process relationship: in_taxon NCBITaxon:33208 ! Metazoa @@ -44201,24 +73318,13 @@ def: "The behavioral interactions between organisms for the purpose of mating, o synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior -intersection_of: GO:0007610 ! behavior -intersection_of: part_of GO:0007618 ! mating -relationship: part_of GO:0007618 ! mating - -[Term] -id: GO:0007618 -name: mating -namespace: biological_process -def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] -is_a: GO:0044703 ! multi-organism reproductive process -relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] -is_a: GO:0007618 ! mating +is_a: GO:0007617 ! mating behavior [Term] id: GO:0007622 @@ -44254,6 +73360,17 @@ synonym: "groom" EXACT [] synonym: "grooming behaviour" EXACT [] is_a: GO:0007610 ! behavior +[Term] +id: GO:0007626 +name: locomotory behavior +def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [] +synonym: "behavior via locomotion" EXACT [] +synonym: "locomotion in response to stimulus" EXACT [] +synonym: "locomotory behavioral response to stimulus" EXACT [] +synonym: "locomotory behaviour" EXACT [] +synonym: "locomotory behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior + [Term] id: GO:0007631 name: feeding behavior @@ -44336,6 +73453,47 @@ is_a: CARO:0000000 ! anatomical entity is_a: GO:0070382 ! exocytic vesicle relationship: part_of GO:0098793 ! presynapse +[Term] +id: GO:0008028 +name: monocarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008505 +def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] +synonym: "monocarboxylate carrier" NARROW [] +synonym: "prostaglandin/thromboxane transporter activity" NARROW [] +xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" +xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:25384 ! monocarboxylic acid +relationship: has_primary_input CHEBI:25384 ! monocarboxylic acid +relationship: part_of GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0008046 +name: axon guidance receptor activity +def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [] +synonym: "receptor activity involved in axon guidance" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +intersection_of: GO:0004888 ! transmembrane signaling receptor activity +intersection_of: part_of GO:0007411 ! axon guidance +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:0008047 +name: enzyme activator activity +namespace: molecular_function +alt_id: GO:0010577 +def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +synonym: "metalloenzyme activator activity" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: positively_regulates GO:0003824 ! catalytic activity +relationship: positively_regulates GO:0003824 ! catalytic activity + [Term] id: GO:0008066 name: glutamate receptor activity @@ -44416,6 +73574,7 @@ subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_yeast +subset: prokaryote_subset is_a: GO:0005515 ! protein binding [Term] @@ -44423,17 +73582,23 @@ id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 +alt_id: GO:0016249 +alt_id: GO:0034613 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: goslim_drosophila synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] +synonym: "cellular protein localisation" EXACT [GOC:mah] +synonym: "cellular protein localization" EXACT [] +synonym: "channel localizer activity" NARROW [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] -is_a: GO:0033036 ! macromolecule localization +is_a: GO:0070727 ! cellular macromolecule localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein -relationship: transports_or_maintains_localization_of PR:000000001 ! protein +intersection_of: has_primary_input PR:000000001 ! protein +relationship: has_primary_input PR:000000001 ! protein +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0008112 @@ -44480,6 +73645,7 @@ subset: goslim_drosophila subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] +synonym: "transcription regulator binding" RELATED [] is_a: GO:0005515 ! protein binding property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19354 xsd:anyURI @@ -44531,6 +73697,7 @@ synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase +disjoint_from: GO:0051179 ! localization created_by: jl creation_date: 2012-10-17T15:46:40Z @@ -44613,6 +73780,36 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:35341 ! steroid relationship: has_primary_input_or_output CHEBI:35341 ! steroid +[Term] +id: GO:0008206 +name: bile acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] +synonym: "bile acid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:36235 ! bile acid anion +relationship: has_primary_input_or_output CHEBI:36235 ! bile acid anion + +[Term] +id: GO:0008211 +name: glucocorticoid metabolic process +def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [] +synonym: "glucocorticoid metabolism" EXACT [] +synonym: "glucocorticosteroid metabolic process" EXACT [] +synonym: "glucocorticosteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0008212 +name: mineralocorticoid metabolic process +def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [] +synonym: "mineralocorticoid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + [Term] id: GO:0008217 name: regulation of blood pressure @@ -44663,8 +73860,8 @@ synonym: "sulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:16189 ! sulfate -relationship: transports_or_maintains_localization_of CHEBI:16189 ! sulfate +intersection_of: has_primary_input CHEBI:16189 ! sulfate +relationship: has_primary_input CHEBI:16189 ! sulfate [Term] id: GO:0008277 @@ -44734,6 +73931,18 @@ intersection_of: negatively_regulates GO:0008283 ! cell population proliferation relationship: negatively_regulates GO:0008283 ! cell population proliferation property_value: RO:0002161 NCBITaxon:4751 +[Term] +id: GO:0008286 +name: insulin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] +synonym: "daf-2 receptor signaling pathway" NARROW [] +synonym: "insulin receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: part_of GO:0032869 ! cellular response to insulin stimulus + [Term] id: GO:0008289 name: lipid binding @@ -44749,6 +73958,7 @@ subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset is_a: GO:0005488 ! binding intersection_of: GO:0005488 ! binding intersection_of: has_input CHEBI:18059 ! lipid @@ -44783,15 +73993,6 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:15355 ! acetylcholine relationship: has_primary_output CHEBI:15355 ! acetylcholine -[Term] -id: GO:0008301 -name: DNA binding, bending -namespace: molecular_function -def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] -synonym: "DNA bending activity" EXACT [] -synonym: "DNA bending involving DNA binding" EXACT [] -is_a: GO:0003677 ! DNA binding - [Term] id: GO:0008306 name: associative learning @@ -44804,6 +74005,53 @@ synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning +[Term] +id: GO:0008320 +name: protein transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015266 +alt_id: GO:0015463 +def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] +synonym: "protein channel activity" RELATED [] +xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" +xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix" +xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" +xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" +xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" +xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)" +xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)" +xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol" +xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" +xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol" +xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" +xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" +xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation" +xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation" +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +is_a: GO:0140318 ! protein transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: has_primary_input PR:000000001 ! protein +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: part_of GO:0071806 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! protein transmembrane transport + +[Term] +id: GO:0008324 +name: cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "transmembrane cation transporter activity" EXACT [] +is_a: GO:0015075 ! ion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:36916 ! cation +relationship: has_primary_input CHEBI:36916 ! cation +relationship: part_of GO:0098655 ! cation transmembrane transport + [Term] id: GO:0008347 name: glial cell migration @@ -44834,6 +74082,7 @@ synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0031348 ! negative regulation of defense response is_a: GO:0032102 ! negative regulation of response to external stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019730 ! antimicrobial humoral response @@ -44988,6 +74237,49 @@ xref: EC:2.6.1.- xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine" is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups +[Term] +id: GO:0008504 +name: monoamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015201 +def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] +xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" +xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" +xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" +xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" +xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" +is_a: GO:0022804 ! active transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:63534 ! monoamine +relationship: has_primary_input CHEBI:63534 ! monoamine +relationship: part_of GO:0015844 ! monoamine transport + +[Term] +id: GO:0008509 +name: anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "anion transporter activity" EXACT [] +xref: Reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface" +is_a: GO:0015075 ! ion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:22563 ! anion +relationship: has_primary_input CHEBI:22563 ! anion +relationship: part_of GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0008514 +name: organic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] +xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" +is_a: GO:0008509 ! anion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:25696 ! organic anion +relationship: has_primary_input CHEBI:25696 ! organic anion +relationship: part_of GO:0015711 ! organic anion transport + [Term] id: GO:0008527 name: taste receptor activity @@ -45083,8 +74375,8 @@ subset: goslim_yeast synonym: "sugar transport" NARROW [] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:16646 ! carbohydrate -relationship: transports_or_maintains_localization_of CHEBI:16646 ! carbohydrate +intersection_of: has_primary_input CHEBI:16646 ! carbohydrate +relationship: has_primary_input CHEBI:16646 ! carbohydrate [Term] id: GO:0008645 @@ -45100,6 +74392,10 @@ synonym: "hexose transport" RELATED [] synonym: "high-affinity hexose transport" NARROW [] synonym: "low-affinity hexose transport" NARROW [] is_a: GO:0015749 ! monosaccharide transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:18133 ! hexose +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:18133 ! hexose created_by: bf creation_date: 2010-04-08T10:27:23Z @@ -45165,6 +74461,9 @@ synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33694 ! biomacromolecule +relationship: has_primary_input CHEBI:33694 ! biomacromolecule [Term] id: GO:0009058 @@ -45214,6 +74513,22 @@ xref: MetaCyc:PWY-3781 xref: Wikipedia:Cellular_respiration#Aerobic_respiration is_a: GO:0045333 ! cellular respiration +[Term] +id: GO:0009063 +name: cellular amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] +synonym: "amino acid catabolic process" EXACT [] +synonym: "cellular amino acid breakdown" EXACT [] +synonym: "cellular amino acid catabolism" EXACT [] +synonym: "cellular amino acid degradation" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:37022 ! amino-acid anion +relationship: has_primary_input CHEBI:37022 ! amino-acid anion + [Term] id: GO:0009064 name: glutamine family amino acid metabolic process @@ -45225,6 +74540,20 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:24318 ! glutamine family amino acid relationship: has_primary_input_or_output CHEBI:24318 ! glutamine family amino acid +[Term] +id: GO:0009065 +name: glutamine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +synonym: "glutamine family amino acid breakdown" EXACT [] +synonym: "glutamine family amino acid catabolism" EXACT [] +synonym: "glutamine family amino acid degradation" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:24318 ! glutamine family amino acid +relationship: has_primary_input CHEBI:24318 ! glutamine family amino acid + [Term] id: GO:0009066 name: aspartate family amino acid metabolic process @@ -45350,6 +74679,44 @@ def: "The chemical reactions and pathways involving purine nucleoside diphosphat synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process +[Term] +id: GO:0009141 +name: nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009142 +name: nucleoside triphosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [] +synonym: "nucleoside triphosphate anabolism" EXACT [] +synonym: "nucleoside triphosphate biosynthesis" EXACT [] +synonym: "nucleoside triphosphate formation" EXACT [] +synonym: "nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0009144 +name: purine nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009145 +name: purine nucleoside triphosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [] +synonym: "purine nucleoside triphosphate anabolism" EXACT [] +synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside triphosphate formation" EXACT [] +synonym: "purine nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process + [Term] id: GO:0009150 name: purine ribonucleotide metabolic process @@ -45359,6 +74726,29 @@ synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process +[Term] +id: GO:0009152 +name: purine ribonucleotide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [] +synonym: "purine ribonucleotide anabolism" EXACT [] +synonym: "purine ribonucleotide biosynthesis" EXACT [] +synonym: "purine ribonucleotide formation" EXACT [] +synonym: "purine ribonucleotide synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009165 +name: nucleotide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [] +synonym: "nucleotide anabolism" EXACT [] +synonym: "nucleotide biosynthesis" EXACT [] +synonym: "nucleotide formation" EXACT [] +synonym: "nucleotide synthesis" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process @@ -45376,6 +74766,46 @@ def: "The chemical reactions and pathways involving a ribonucleoside diphosphate synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process +[Term] +id: GO:0009199 +name: ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009201 +name: ribonucleoside triphosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [] +synonym: "ribonucleoside triphosphate anabolism" EXACT [] +synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside triphosphate formation" EXACT [] +synonym: "ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009205 +name: purine ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009206 +name: purine ribonucleoside triphosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [] +synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside triphosphate formation" EXACT [] +synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process +is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + [Term] id: GO:0009235 name: cobalamin metabolic process @@ -45388,6 +74818,21 @@ synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process +[Term] +id: GO:0009250 +name: glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] +synonym: "glucan anabolism" EXACT [] +synonym: "glucan biosynthesis" EXACT [] +synonym: "glucan formation" EXACT [] +synonym: "glucan synthesis" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:37163 ! glucan +relationship: has_primary_output CHEBI:37163 ! glucan + [Term] id: GO:0009251 name: glucan catabolic process @@ -45398,6 +74843,9 @@ synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:37163 ! glucan +relationship: has_primary_input CHEBI:37163 ! glucan [Term] id: GO:0009259 @@ -45409,6 +74857,18 @@ synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process +[Term] +id: GO:0009260 +name: ribonucleotide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [] +synonym: "ribonucleotide anabolism" EXACT [] +synonym: "ribonucleotide biosynthesis" EXACT [] +synonym: "ribonucleotide formation" EXACT [] +synonym: "ribonucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009259 ! ribonucleotide metabolic process +is_a: GO:0046390 ! ribose phosphate biosynthetic process + [Term] id: GO:0009266 name: response to temperature stimulus @@ -45439,7 +74899,7 @@ is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell is_a: GO:0035592 ! establishment of protein localization to extracellular region intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein +intersection_of: has_primary_input PR:000000001 ! protein [Term] id: GO:0009308 @@ -45470,6 +74930,20 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:32952 ! amine relationship: has_primary_output CHEBI:32952 ! amine +[Term] +id: GO:0009310 +name: amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] +synonym: "amine breakdown" EXACT [] +synonym: "amine catabolism" EXACT [] +synonym: "amine degradation" EXACT [] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:32952 ! amine +relationship: has_primary_input CHEBI:32952 ! amine + [Term] id: GO:0009314 name: response to radiation @@ -45622,7 +75096,12 @@ def: "The union of gametes of opposite sexes during the process of sexual reprod synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process +intersection_of: GO:0022414 ! reproductive process +intersection_of: results_in_formation_of CL:0010017 ! zygote +intersection_of: results_in_fusion_of GO:0043073 ! germ cell nucleus relationship: part_of GO:0019953 ! sexual reproduction +relationship: results_in_formation_of CL:0010017 ! zygote +relationship: results_in_fusion_of GO:0043073 ! germ cell nucleus property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20176 xsd:anyURI [Term] @@ -45644,6 +75123,7 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant +subset: prokaryote_subset synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0005622 ! intracellular anatomical structure @@ -45802,6 +75282,7 @@ synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process disjoint_from: GO:0048856 ! anatomical structure development +disjoint_from: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048856 ! anatomical structure development [Term] @@ -45878,11 +75359,33 @@ intersection_of: GO:0050896 ! response to stimulus intersection_of: has_input CHEBI:16646 ! carbohydrate relationship: has_input CHEBI:16646 ! carbohydrate +[Term] +id: GO:0009746 +name: response to hexose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] +synonym: "response to hexose stimulus" EXACT [GOC:dos] +is_a: GO:0034284 ! response to monosaccharide +intersection_of: GO:0050896 ! response to stimulus +intersection_of: has_input CHEBI:18133 ! hexose +relationship: has_input CHEBI:18133 ! hexose + +[Term] +id: GO:0009749 +name: response to glucose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] +synonym: "response to glucose stimulus" EXACT [GOC:dos] +is_a: GO:0009746 ! response to hexose +intersection_of: GO:0050896 ! response to stimulus +intersection_of: has_input CHEBI:17234 ! glucose +relationship: has_input CHEBI:17234 ! glucose + [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] +def: "The series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0032870 ! cellular response to hormone stimulus @@ -45966,19 +75469,34 @@ relationship: has_primary_input_or_output CHEBI:22315 ! alkaloid id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] +def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process -is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:22315 ! alkaloid relationship: has_primary_output CHEBI:22315 ! alkaloid +[Term] +id: GO:0009822 +name: alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] +synonym: "alkaloid breakdown" EXACT [] +synonym: "alkaloid catabolism" EXACT [] +synonym: "alkaloid degradation" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:22315 ! alkaloid +relationship: has_primary_input CHEBI:22315 ! alkaloid + [Term] id: GO:0009855 name: determination of bilateral symmetry @@ -46302,6 +75820,20 @@ disjoint_from: GO:0044848 ! biological phase created_by: jl creation_date: 2012-12-11T16:56:55Z +[Term] +id: GO:0009994 +name: oocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] +synonym: "oocyte cell differentiation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030154 ! cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000023 ! oocyte +relationship: part_of GO:0048477 ! oogenesis +relationship: results_in_acquisition_of_features_of CL:0000023 ! oocyte + [Term] id: GO:0009996 name: negative regulation of cell fate specification @@ -46424,6 +75956,9 @@ namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division +intersection_of: GO:0008356 ! asymmetric cell division +intersection_of: has_input CL:0000365 ! animal zygote +relationship: has_input CL:0000365 ! animal zygote [Term] id: GO:0010160 @@ -46599,6 +76134,26 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010481 ! epidermal cell division relationship: regulates GO:0010481 ! epidermal cell division +[Term] +id: GO:0010496 +name: intercellular transport +namespace: biological_process +alt_id: GO:1902585 +def: "The movement of substances between cells." [GOC:dhl] +synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] +synonym: "single-organism intercellular transport" RELATED [] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location CL:0000000 ! cell +intersection_of: has_target_start_location CL:0000000 ! cell +intersection_of: results_in_transport_across GO:0005615 ! extracellular space +relationship: has_target_end_location CL:0000000 ! cell +relationship: has_target_start_location CL:0000000 ! cell +relationship: results_in_transport_across GO:0005615 ! extracellular space +created_by: jl +creation_date: 2013-12-19T13:24:56Z + [Term] id: GO:0010543 name: regulation of platelet activation @@ -46835,9 +76390,10 @@ relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010608 -name: posttranscriptional regulation of gene expression +name: post-transcriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] +synonym: "posttranscriptional regulation of gene expression" EXACT [] is_a: GO:0010468 ! regulation of gene expression [Term] @@ -47313,6 +76869,7 @@ namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion +is_a: GO:0043271 ! negative regulation of ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048243 ! norepinephrine secretion relationship: negatively_regulates GO:0048243 ! norepinephrine secretion @@ -47324,10 +76881,44 @@ namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion +is_a: GO:0043270 ! positive regulation of ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048243 ! norepinephrine secretion relationship: positively_regulates GO:0048243 ! norepinephrine secretion +[Term] +id: GO:0010710 +name: regulation of collagen catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0030574 ! collagen catabolic process +relationship: regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0010711 +name: negative regulation of collagen catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010710 ! regulation of collagen catabolic process +is_a: GO:0010713 ! negative regulation of collagen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0030574 ! collagen catabolic process +relationship: negatively_regulates GO:0030574 ! collagen catabolic process + [Term] id: GO:0010712 name: regulation of collagen metabolic process @@ -47530,6 +77121,28 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010761 ! fibroblast migration relationship: negatively_regulates GO:0010761 ! fibroblast migration +[Term] +id: GO:0010765 +name: positive regulation of sodium ion transport +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043270 ! positive regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006814 ! sodium ion transport +relationship: positively_regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0010766 +name: negative regulation of sodium ion transport +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043271 ! negative regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006814 ! sodium ion transport +relationship: negatively_regulates GO:0006814 ! sodium ion transport + [Term] id: GO:0010769 name: regulation of cell morphogenesis involved in differentiation @@ -47751,27 +77364,6 @@ relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye relationship: results_in_formation_of UBERON:0001781 ! layer of retina -[Term] -id: GO:0010847 -name: regulation of chromatin assembly -namespace: biological_process -def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb] -is_a: GO:0001672 ! regulation of chromatin assembly or disassembly -is_a: GO:0044087 ! regulation of cellular component biogenesis -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0031497 ! chromatin assembly -relationship: regulates GO:0031497 ! chromatin assembly - -[Term] -id: GO:0010848 -name: regulation of chromatin disassembly -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb] -is_a: GO:0001672 ! regulation of chromatin assembly or disassembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0031498 ! chromatin disassembly -relationship: regulates GO:0031498 ! chromatin disassembly - [Term] id: GO:0010872 name: regulation of cholesterol esterification @@ -47824,8 +77416,8 @@ def: "Any process in which a lipid is transported to, or maintained in, a specif synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization -intersection_of: transports_or_maintains_localization_of CHEBI:18059 ! lipid -relationship: transports_or_maintains_localization_of CHEBI:18059 ! lipid +intersection_of: has_primary_input CHEBI:18059 ! lipid +relationship: has_primary_input CHEBI:18059 ! lipid [Term] id: GO:0010892 @@ -48099,6 +77691,20 @@ is_a: GO:0072507 ! divalent inorganic cation homeostasis created_by: tb creation_date: 2009-05-06T11:47:17Z +[Term] +id: GO:0010962 +name: regulation of glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0009250 ! glucan biosynthetic process +relationship: regulates GO:0009250 ! glucan biosynthetic process +created_by: tb +creation_date: 2009-05-11T12:17:53Z + [Term] id: GO:0010966 name: regulation of phosphate transport @@ -48198,6 +77804,7 @@ alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. subset: goslim_generic +subset: prokaryote_subset synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] @@ -48216,7 +77823,6 @@ id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast @@ -48356,7 +77962,9 @@ relationship: results_in_development_of CL:0000031 ! neuroblast (sensu Vertebrat id: GO:0014020 name: primary neural tube formation namespace: biological_process -def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] +alt_id: GO:0014024 +def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780] +synonym: "neural rod cavitation" RELATED [] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation @@ -48375,18 +77983,6 @@ relationship: only_in_taxon NCBITaxon:32443 ! Teleostei relationship: part_of GO:0014020 ! primary neural tube formation relationship: results_in_formation_of UBERON:0005068 ! neural rod -[Term] -id: GO:0014024 -name: neural rod cavitation -namespace: biological_process -def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] -is_a: GO:0060605 ! tube lumen cavitation -intersection_of: GO:0060605 ! tube lumen cavitation -intersection_of: part_of GO:0014020 ! primary neural tube formation -intersection_of: results_in_formation_of UBERON:0003842 ! neural tube lumen -relationship: part_of GO:0014020 ! primary neural tube formation -relationship: results_in_formation_of UBERON:0003842 ! neural tube lumen - [Term] id: GO:0014025 name: neural keel formation @@ -48438,12 +78034,11 @@ id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] -is_a: GO:0014031 ! mesenchymal cell development is_a: GO:0048864 ! stem cell development intersection_of: GO:0032502 ! developmental process -intersection_of: results_in_development_of CL:0000333 ! migratory neural crest cell +intersection_of: results_in_development_of CL:0011012 ! neural crest cell relationship: part_of GO:0014033 ! neural crest cell differentiation -relationship: results_in_development_of CL:0000333 ! migratory neural crest cell +relationship: results_in_development_of CL:0011012 ! neural crest cell [Term] id: GO:0014033 @@ -48568,8 +78163,9 @@ namespace: biological_process def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] is_a: GO:0015872 ! dopamine transport is_a: GO:0023061 ! signal release +is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:59905 ! dopaminium(1+) +intersection_of: has_primary_input CHEBI:59905 ! dopaminium(1+) [Term] id: GO:0014047 @@ -48580,8 +78176,8 @@ is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:14321 ! glutamate(1-) -relationship: transports_or_maintains_localization_of CHEBI:14321 ! glutamate(1-) +intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) +relationship: has_primary_input CHEBI:14321 ! glutamate(1-) [Term] id: GO:0014048 @@ -48630,6 +78226,61 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0014047 ! glutamate secretion relationship: negatively_regulates GO:0014047 ! glutamate secretion +[Term] +id: GO:0014051 +name: gamma-aminobutyric acid secretion +def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [] +synonym: "GABA secretion" EXACT [] +is_a: GO:0015812 ! gamma-aminobutyric acid transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0014052 +name: regulation of gamma-aminobutyric acid secretion +def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [] +synonym: "regulation of GABA secretion" EXACT [] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051955 ! regulation of amino acid transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0014051 ! gamma-aminobutyric acid secretion +relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014053 +name: negative regulation of gamma-aminobutyric acid secretion +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [] +synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] +synonym: "negative regulation of GABA secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903792 ! negative regulation of anion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion +relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014054 +name: positive regulation of gamma-aminobutyric acid secretion +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [] +synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "positive regulation of GABA secretion" EXACT [] +synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903793 ! positive regulation of anion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion +relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission @@ -48697,7 +78348,7 @@ name: regulation of dopamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] is_a: GO:0043269 ! regulation of ion transport -is_a: GO:1903530 ! regulation of secretion by cell +is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0014046 ! dopamine secretion relationship: regulates GO:0014046 ! dopamine secretion @@ -48719,6 +78370,7 @@ name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] +is_a: GO:0043269 ! regulation of ion transport is_a: GO:0050433 ! regulation of catecholamine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048243 ! norepinephrine secretion @@ -49264,13 +78916,311 @@ is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein +intersection_of: has_primary_input PR:000000001 ! protein + +[Term] +id: GO:0015075 +name: ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "ion transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24870 ! ion +relationship: has_primary_input CHEBI:24870 ! ion +relationship: part_of GO:0034220 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! ion transmembrane transport + +[Term] +id: GO:0015081 +name: sodium ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0022816 +def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] +synonym: "sodium transporter activity" EXACT [] +is_a: GO:0046873 ! metal ion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) +relationship: has_primary_input CHEBI:29101 ! sodium(1+) +relationship: part_of GO:0035725 ! sodium ion transmembrane transport + +[Term] +id: GO:0015101 +name: organic cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" +xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" +xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" +xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" +xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" +xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" +xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" +is_a: GO:0008324 ! cation transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:25697 ! organic cation +relationship: has_primary_input CHEBI:25697 ! organic cation +relationship: part_of GO:0015695 ! organic cation transport + +[Term] +id: GO:0015103 +name: inorganic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24834 ! inorganic anion +relationship: has_primary_input CHEBI:24834 ! inorganic anion +relationship: part_of GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015106 +name: bicarbonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] +xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" +xref: RHEA:28695 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate +relationship: has_primary_input CHEBI:17544 ! hydrogencarbonate +relationship: part_of GO:0015701 ! bicarbonate transport + +[Term] +id: GO:0015114 +name: phosphate ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901677 +def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] +synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw] +xref: RHEA:32823 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:35780 ! phosphate ion +relationship: has_primary_input CHEBI:35780 ! phosphate ion +relationship: part_of GO:0035435 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! phosphate ion transmembrane transport +created_by: pr +creation_date: 2012-11-22T15:43:10Z + +[Term] +id: GO:0015116 +name: sulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] +synonym: "sulfate permease activity" RELATED [] +synonym: "sulphate transporter activity" EXACT [] +xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol" +xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" +xref: RHEA:34983 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:16189 ! sulfate +relationship: has_primary_input CHEBI:16189 ! sulfate +relationship: part_of GO:1902358 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! sulfate transmembrane transport + +[Term] +id: GO:0015123 +name: acetate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:30089 ! acetate +relationship: has_primary_input CHEBI:30089 ! acetate +relationship: part_of GO:0035433 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! acetate transmembrane transport + +[Term] +id: GO:0015125 +name: bile acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] +xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" +xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" +xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" +xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:3098 ! bile acid +relationship: has_primary_input CHEBI:3098 ! bile acid +relationship: part_of GO:0015721 ! bile acid and bile salt transport + +[Term] +id: GO:0015127 +name: bilirubin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] +xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region" +xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" +xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:57977 ! bilirubin(2-) +relationship: has_primary_input CHEBI:57977 ! bilirubin(2-) +relationship: part_of GO:0015723 ! bilirubin transport + +[Term] +id: GO:0015144 +name: carbohydrate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901476 +def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +synonym: "carbohydrate transporter activity" RELATED [] +synonym: "sugar transporter" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:16646 ! carbohydrate +relationship: has_primary_input CHEBI:16646 ! carbohydrate +relationship: part_of GO:0034219 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! carbohydrate transmembrane transport + +[Term] +id: GO:0015145 +name: monosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0051119 ! sugar transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:35381 ! monosaccharide +relationship: has_primary_input CHEBI:35381 ! monosaccharide +relationship: part_of GO:0015749 ! monosaccharide transmembrane transport + +[Term] +id: GO:0015149 +name: hexose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" +xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region" +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:18133 ! hexose +relationship: has_primary_input CHEBI:18133 ! hexose +relationship: part_of GO:0008645 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! hexose transmembrane transport + +[Term] +id: GO:0015159 +name: polysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:18154 ! polysaccharide +relationship: has_primary_input CHEBI:18154 ! polysaccharide +relationship: part_of GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015171 +name: amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015359 +def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "amino acid permease activity" EXACT [] +synonym: "amino acid transporter activity" BROAD [] +synonym: "amino acid/choline transmembrane transporter activity" NARROW [] +synonym: "general amino acid permease activity" RELATED [] +synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] +xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" +xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" +xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" +xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" +xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" +xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" +xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" +xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" +xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" +xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" +xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" +xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" +xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" +xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" +xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" +xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" +xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" +xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" +xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" +xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" +xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" +xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" +xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" +xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" +xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" +xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol" +xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" +xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" +xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" +xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33709 ! amino acid +relationship: has_primary_input CHEBI:33709 ! amino acid +relationship: part_of GO:0003333 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! amino acid transmembrane transport + +[Term] +id: GO:0015179 +name: L-amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-amino acid transporter activity" BROAD [] +xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes" +is_a: GO:0015171 ! amino acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:15705 ! L-alpha-amino acid +relationship: has_primary_input CHEBI:15705 ! L-alpha-amino acid +relationship: part_of GO:0015807 ! L-amino acid transport +relationship: part_of GO:1902475 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0015205 +name: nucleobase transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015392 +def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:18282 ! nucleobase +relationship: has_primary_input CHEBI:18282 ! nucleobase +relationship: part_of GO:0015851 ! nucleobase transport + +[Term] +id: GO:0015318 +name: inorganic molecular entity transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] +subset: gocheck_do_not_annotate +synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] +synonym: "inorganic uptake permease activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24835 ! inorganic molecular entity +relationship: has_primary_input CHEBI:24835 ! inorganic molecular entity +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14372 xsd:anyURI [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function -def: "Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +def: "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity @@ -49285,7 +79235,6 @@ id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] -subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] @@ -49293,7 +79242,6 @@ id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] -subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] @@ -49318,8 +79266,8 @@ namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:15379 ! dioxygen -relationship: transports_or_maintains_localization_of CHEBI:15379 ! dioxygen +intersection_of: has_primary_input CHEBI:15379 ! dioxygen +relationship: has_primary_input CHEBI:15379 ! dioxygen [Term] id: GO:0015695 @@ -49329,8 +79277,8 @@ def: "The directed movement of organic cations into, out of or within a cell, or is_a: GO:0006812 ! cation transport is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:25697 ! organic cation -relationship: transports_or_maintains_localization_of CHEBI:25697 ! organic cation +intersection_of: has_primary_input CHEBI:25697 ! organic cation +relationship: has_primary_input CHEBI:25697 ! organic cation [Term] id: GO:0015698 @@ -49339,8 +79287,18 @@ namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006820 ! anion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:24834 ! inorganic anion -relationship: transports_or_maintains_localization_of CHEBI:24834 ! inorganic anion +intersection_of: has_primary_input CHEBI:24834 ! inorganic anion +relationship: has_primary_input CHEBI:24834 ! inorganic anion + +[Term] +id: GO:0015701 +name: bicarbonate transport +namespace: biological_process +def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015711 ! organic anion transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate +relationship: has_primary_input CHEBI:17544 ! hydrogencarbonate [Term] id: GO:0015711 @@ -49350,8 +79308,8 @@ def: "The directed movement of organic anions into, out of or within a cell, or is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:25696 ! organic anion -relationship: transports_or_maintains_localization_of CHEBI:25696 ! organic anion +intersection_of: has_primary_input CHEBI:25696 ! organic anion +relationship: has_primary_input CHEBI:25696 ! organic anion [Term] id: GO:0015718 @@ -49360,8 +79318,33 @@ namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:35757 ! monocarboxylic acid anion -relationship: transports_or_maintains_localization_of CHEBI:35757 ! monocarboxylic acid anion +intersection_of: has_primary_input CHEBI:35757 ! monocarboxylic acid anion +relationship: has_primary_input CHEBI:35757 ! monocarboxylic acid anion + +[Term] +id: GO:0015721 +name: bile acid and bile salt transport +namespace: biological_process +def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] +synonym: "bile acid transport" NARROW [] +synonym: "bile salt transport" NARROW [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:3098 ! bile acid +relationship: has_primary_input CHEBI:3098 ! bile acid + +[Term] +id: GO:0015723 +name: bilirubin transport +namespace: biological_process +def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0006835 ! dicarboxylic acid transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:57977 ! bilirubin(2-) +relationship: has_primary_input CHEBI:57977 ! bilirubin(2-) [Term] id: GO:0015749 @@ -49371,6 +79354,10 @@ alt_id: GO:1905950 def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] synonym: "monosaccharide transport" RELATED [] is_a: GO:0034219 ! carbohydrate transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:35381 ! monosaccharide +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:35381 ! monosaccharide created_by: vw creation_date: 2017-02-19T10:41:27Z @@ -49381,9 +79368,9 @@ namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:18154 ! polysaccharide +intersection_of: has_primary_input CHEBI:18154 ! polysaccharide +relationship: has_primary_input CHEBI:18154 ! polysaccharide relationship: part_of GO:0033037 ! polysaccharide localization -relationship: transports_or_maintains_localization_of CHEBI:18154 ! polysaccharide [Term] id: GO:0015800 @@ -49400,8 +79387,18 @@ def: "The directed movement of L-enantiomer amino acids into, out of or within a is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:59814 ! L-alpha-amino acid anion -relationship: transports_or_maintains_localization_of CHEBI:59814 ! L-alpha-amino acid anion +intersection_of: has_primary_input CHEBI:59814 ! L-alpha-amino acid anion +relationship: has_primary_input CHEBI:59814 ! L-alpha-amino acid anion + +[Term] +id: GO:0015812 +name: gamma-aminobutyric acid transport +def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [] +synonym: "4-aminobutanoate transport" EXACT [] +synonym: "4-aminobutyrate transport" EXACT [] +synonym: "GABA transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015833 @@ -49412,8 +79409,8 @@ subset: goslim_pir is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:16670 ! peptide -relationship: transports_or_maintains_localization_of CHEBI:16670 ! peptide +intersection_of: has_primary_input CHEBI:16670 ! peptide +relationship: has_primary_input CHEBI:16670 ! peptide [Term] id: GO:0015837 @@ -49425,8 +79422,8 @@ synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:32952 ! amine -relationship: transports_or_maintains_localization_of CHEBI:32952 ! amine +intersection_of: has_primary_input CHEBI:32952 ! amine +relationship: has_primary_input CHEBI:32952 ! amine [Term] id: GO:0015844 @@ -49437,8 +79434,8 @@ def: "The directed movement of monoamines, organic compounds that contain one am is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:63534 ! monoamine -relationship: transports_or_maintains_localization_of CHEBI:63534 ! monoamine +intersection_of: has_primary_input CHEBI:63534 ! monoamine +relationship: has_primary_input CHEBI:63534 ! monoamine [Term] id: GO:0015849 @@ -49448,8 +79445,8 @@ def: "The directed movement of organic acids, any acidic compound containing car subset: goslim_pir is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:64709 ! organic acid -relationship: transports_or_maintains_localization_of CHEBI:64709 ! organic acid +intersection_of: has_primary_input CHEBI:64709 ! organic acid +relationship: has_primary_input CHEBI:64709 ! organic acid [Term] id: GO:0015850 @@ -49459,8 +79456,8 @@ def: "The directed movement of an organic hydroxy compound (organic alcohol) int synonym: "organic alcohol transport" EXACT [] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33822 ! organic hydroxy compound -relationship: transports_or_maintains_localization_of CHEBI:33822 ! organic hydroxy compound +intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound +relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound [Term] id: GO:0015851 @@ -49471,8 +79468,8 @@ synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:18282 ! nucleobase -relationship: transports_or_maintains_localization_of CHEBI:18282 ! nucleobase +intersection_of: has_primary_input CHEBI:18282 ! nucleobase +relationship: has_primary_input CHEBI:18282 ! nucleobase [Term] id: GO:0015870 @@ -49483,8 +79480,8 @@ is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:15355 ! acetylcholine -relationship: transports_or_maintains_localization_of CHEBI:15355 ! acetylcholine +intersection_of: has_primary_input CHEBI:15355 ! acetylcholine +relationship: has_primary_input CHEBI:15355 ! acetylcholine [Term] id: GO:0015872 @@ -49492,10 +79489,10 @@ name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0006812 ! cation transport -is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:59905 ! dopaminium(1+) -relationship: transports_or_maintains_localization_of CHEBI:59905 ! dopaminium(1+) +intersection_of: has_primary_input CHEBI:59905 ! dopaminium(1+) +relationship: has_primary_input CHEBI:59905 ! dopaminium(1+) [Term] id: GO:0015874 @@ -49504,10 +79501,11 @@ namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] +is_a: GO:0015695 ! organic cation transport is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33569 ! noradrenaline -relationship: transports_or_maintains_localization_of CHEBI:33569 ! noradrenaline +intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) [Term] id: GO:0015918 @@ -49528,8 +79526,20 @@ synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:61120 ! nucleobase-containing molecular entity -relationship: transports_or_maintains_localization_of CHEBI:61120 ! nucleobase-containing molecular entity +intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity +relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity + +[Term] +id: GO:0015932 +name: nucleobase-containing compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity +relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity +relationship: part_of GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0015980 @@ -49539,6 +79549,14 @@ def: "The chemical reactions and pathways by which a cell derives energy from or synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy +[Term] +id: GO:0015986 +name: proton motive force-driven ATP synthesis +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [] +synonym: "ATP synthesis coupled proton transport" EXACT [] +synonym: "chemiosmosis" BROAD [] +is_a: GO:0006754 ! ATP biosynthetic process + [Term] id: GO:0016020 name: membrane @@ -49546,7 +79564,6 @@ namespace: cellular_component alt_id: GO:0098589 alt_id: GO:0098805 def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon @@ -49589,6 +79606,9 @@ synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18059 ! lipid +relationship: has_primary_input CHEBI:18059 ! lipid [Term] id: GO:0016043 @@ -49696,6 +79716,9 @@ synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:16646 ! carbohydrate +relationship: has_primary_input CHEBI:16646 ! carbohydrate created_by: jl creation_date: 2012-10-23T16:34:39Z @@ -49716,6 +79739,22 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:64709 ! organic acid relationship: has_primary_output CHEBI:64709 ! organic acid +[Term] +id: GO:0016054 +name: organic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +synonym: "organic acid breakdown" EXACT [] +synonym: "organic acid catabolism" EXACT [] +synonym: "organic acid degradation" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:64709 ! organic acid +relationship: has_primary_input CHEBI:64709 ! organic acid + [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell @@ -49752,10 +79791,10 @@ name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir +subset: prokaryote_subset synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process intersection_of: GO:0008152 ! metabolic process @@ -49788,13 +79827,20 @@ synonym: "diterpene metabolism" NARROW [] synonym: "diterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process +[Term] +id: GO:0016125 +name: sterol metabolic process +def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [] +synonym: "sterol metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -49850,6 +79896,7 @@ def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. U subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir +subset: prokaryote_subset is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: part_of GO:0098869 ! cellular oxidant detoxification @@ -49860,7 +79907,6 @@ id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] -subset: goslim_aspergillus subset: goslim_chembl subset: goslim_drosophila xref: EC:3.1.1.- @@ -49914,6 +79960,21 @@ intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007143 ! female meiotic nuclear division relationship: part_of GO:0007143 ! female meiotic nuclear division +[Term] +id: GO:0016325 +name: oocyte microtubule cytoskeleton organization +namespace: biological_process +alt_id: GO:0048130 +def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] +synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity +intersection_of: GO:0016043 ! cellular component organization +intersection_of: occurs_in CL:0000023 ! oocyte +intersection_of: results_in_organization_of GO:0015630 ! microtubule cytoskeleton +relationship: occurs_in CL:0000023 ! oocyte +relationship: part_of GO:0007308 ! oocyte construction + [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium @@ -50073,7 +80134,6 @@ id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50082,6 +80142,7 @@ subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1.-.-.- @@ -50105,6 +80166,13 @@ xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14( xref: Reactome:R-HSA-9693722 "Unknown sepiapterin synthase transforms PTHP to sepiapterin" is_a: GO:0003824 ! catalytic activity +[Term] +id: GO:0016500 +name: protein-hormone receptor activity +namespace: molecular_function +def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0038023 ! signaling receptor activity + [Term] id: GO:0016525 name: negative regulation of angiogenesis @@ -50336,7 +80404,6 @@ id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50346,6 +80413,7 @@ subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset xref: EC:2.-.-.- xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" @@ -50519,8 +80587,8 @@ is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing grou id: GO:0016787 name: hydrolase activity namespace: molecular_function -def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] -subset: goslim_aspergillus +def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732] +def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50530,6 +80598,7 @@ subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast +subset: prokaryote_subset xref: EC:3.-.-.- xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" @@ -50570,7 +80639,6 @@ namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:curators, GOC:pg] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50593,7 +80661,6 @@ xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P" is_a: GO:0042578 ! phosphoric ester hydrolase activity -relationship: part_of GO:0016311 ! dephosphorylation [Term] id: GO:0016810 @@ -50621,7 +80688,6 @@ id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50629,6 +80695,7 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "other lyase activity" NARROW [] xref: EC:4.-.-.- xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL" @@ -50680,7 +80747,6 @@ id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50688,6 +80754,7 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "other isomerase activity" NARROW [] xref: EC:5.-.-.- xref: Reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" @@ -50738,8 +80805,7 @@ is_a: GO:0016866 ! intramolecular transferase activity id: GO:0016874 name: ligase activity namespace: molecular_function -def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-, GOC:mah] -subset: goslim_aspergillus +def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah] subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila @@ -50748,6 +80814,7 @@ subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast +subset: prokaryote_subset synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6.-.-.- is_a: GO:0003824 ! catalytic activity @@ -50919,13 +80986,22 @@ xref: RHEA:10348 xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides +[Term] +id: GO:0018108 +name: peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] +xref: RESID:AA0039 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + [Term] id: GO:0018126 name: protein hydroxylation namespace: biological_process def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] synonym: "protein amino acid hydroxylation" EXACT [GOC:bf] -is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0036211 ! protein modification process [Term] id: GO:0018130 @@ -50948,7 +81024,8 @@ name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: goslim_yeast -is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0036211 ! protein modification process +relationship: has_input CHEBI:33708 ! amino-acid residue [Term] id: GO:0018208 @@ -50957,6 +81034,13 @@ namespace: biological_process def: "The modification of peptidyl-proline." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification +[Term] +id: GO:0018212 +name: peptidyl-tyrosine modification +namespace: biological_process +def: "The modification of peptidyl-tyrosine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + [Term] id: GO:0018958 name: phenol-containing compound metabolic process @@ -50992,7 +81076,10 @@ synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process intersection_of: GO:0007610 ! behavior +intersection_of: GO:0007610 ! behavior intersection_of: part_of GO:0000003 ! reproduction +intersection_of: part_of GO:0032504 ! multicellular organism reproduction +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23491 xsd:anyURI created_by: jl creation_date: 2012-09-19T16:01:37Z @@ -51012,6 +81099,16 @@ is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0019249 ! lactate biosynthetic process relationship: part_of GO:0061727 ! methylglyoxal catabolic process to lactate +[Term] +id: GO:0019199 +name: transmembrane receptor protein kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] +xref: Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex" +xref: Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated" +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0004888 ! transmembrane signaling receptor activity + [Term] id: GO:0019200 name: carbohydrate kinase activity @@ -51021,6 +81118,39 @@ xref: Reactome:R-HSA-8931653 "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046835 ! carbohydrate phosphorylation +[Term] +id: GO:0019207 +name: kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +is_a: GO:0030234 ! enzyme regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: regulates GO:0016301 ! kinase activity +relationship: regulates GO:0016301 ! kinase activity + +[Term] +id: GO:0019209 +name: kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0019207 ! kinase regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: positively_regulates GO:0016301 ! kinase activity +relationship: part_of GO:0033674 ! positive regulation of kinase activity +relationship: positively_regulates GO:0016301 ! kinase activity + +[Term] +id: GO:0019210 +name: kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0019207 ! kinase regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0016301 ! kinase activity +relationship: negatively_regulates GO:0016301 ! kinase activity + [Term] id: GO:0019216 name: regulation of lipid metabolic process @@ -51171,6 +81301,9 @@ namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:18133 ! hexose +relationship: has_primary_input_or_output CHEBI:18133 ! hexose [Term] id: GO:0019319 @@ -51183,6 +81316,40 @@ synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:18133 ! hexose +relationship: has_primary_output CHEBI:18133 ! hexose + +[Term] +id: GO:0019320 +name: hexose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexose breakdown" EXACT [] +synonym: "hexose catabolism" EXACT [] +synonym: "hexose degradation" EXACT [] +is_a: GO:0019318 ! hexose metabolic process +is_a: GO:0046365 ! monosaccharide catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18133 ! hexose +relationship: has_primary_input CHEBI:18133 ! hexose + +[Term] +id: GO:0019336 +name: phenol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +synonym: "phenol-containing compound breakdown" EXACT [] +synonym: "phenol-containing compound catabolism" EXACT [] +synonym: "phenol-containing compound degradation" EXACT [] +xref: MetaCyc:PHENOLDEG-PWY +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33853 ! phenols +relationship: has_primary_input CHEBI:33853 ! phenols [Term] id: GO:0019413 @@ -51216,6 +81383,22 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33655 ! aromatic compound relationship: has_primary_output CHEBI:33655 ! aromatic compound +[Term] +id: GO:0019439 +name: aromatic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] +synonym: "aromatic compound breakdown" EXACT [] +synonym: "aromatic compound catabolism" EXACT [] +synonym: "aromatic compound degradation" EXACT [] +synonym: "aromatic hydrocarbon catabolic process" NARROW [] +synonym: "aromatic hydrocarbon catabolism" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044248 ! cellular catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33655 ! aromatic compound +relationship: has_primary_input CHEBI:33655 ! aromatic compound + [Term] id: GO:0019511 name: peptidyl-proline hydroxylation @@ -51230,6 +81413,7 @@ id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 +alt_id: GO:0044267 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr @@ -51237,6 +81421,8 @@ subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant +synonym: "cellular protein metabolic process" EXACT [] +synonym: "cellular protein metabolism" EXACT [] synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] @@ -51248,6 +81434,22 @@ is_a: GO:1901564 ! organonitrogen compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output PR:000000001 ! protein relationship: has_primary_input_or_output PR:000000001 ! protein +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI + +[Term] +id: GO:0019614 +name: catechol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +synonym: "catechol breakdown" RELATED [] +synonym: "catechol catabolic process" RELATED [] +synonym: "catechol catabolism" RELATED [] +synonym: "catechol degradation" RELATED [] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33566 ! catechols +relationship: has_primary_input CHEBI:33566 ! catechols [Term] id: GO:0019637 @@ -51287,7 +81489,6 @@ id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant is_a: GO:0009987 ! cellular process @@ -51307,7 +81508,7 @@ alt_id: GO:0006960 alt_id: GO:0019735 def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0006959 ! humoral immune response -is_a: GO:0051707 ! response to other organism +is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0019747 @@ -51326,7 +81527,6 @@ id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] -subset: goslim_aspergillus subset: goslim_chembl subset: goslim_pir subset: goslim_plant @@ -51356,8 +81556,8 @@ def: "The directed movement of one-carbon compounds into, out of or within a cel synonym: "one carbon compound transport" EXACT [] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:64708 ! one-carbon compound -relationship: transports_or_maintains_localization_of CHEBI:64708 ! one-carbon compound +intersection_of: has_primary_input CHEBI:64708 ! one-carbon compound +relationship: has_primary_input CHEBI:64708 ! one-carbon compound [Term] id: GO:0019798 @@ -51376,6 +81576,20 @@ subset: goslim_pir synonym: "antibody" NARROW [] is_a: GO:0032991 ! protein-containing complex +[Term] +id: GO:0019815 +name: B cell receptor complex +def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [] +synonym: "antibody" RELATED [] +synonym: "B cell receptor accessory molecule complex" RELATED [] +synonym: "B lymphocyte receptor complex" EXACT [] +synonym: "B-cell receptor complex" EXACT [] +synonym: "B-lymphocyte receptor complex" EXACT [] +synonym: "BCR complex" EXACT [] +synonym: "immunoglobulin complex, membrane bound" EXACT [] +is_a: GO:0019814 ! immunoglobulin complex +is_a: GO:0098802 ! plasma membrane signaling receptor complex + [Term] id: GO:0019825 name: oxygen binding @@ -51433,15 +81647,49 @@ synonym: "antigen processing" EXACT [] xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process +[Term] +id: GO:0019887 +name: protein kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019207 ! kinase regulator activity +intersection_of: GO:0003674 ! molecular_function +intersection_of: regulates GO:0004672 ! protein kinase activity +relationship: has_part GO:0019901 ! protein kinase binding +relationship: regulates GO:0004672 ! protein kinase activity + +[Term] +id: GO:0019899 +name: enzyme binding +namespace: molecular_function +def: "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] +subset: goslim_chembl +subset: goslim_yeast +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019900 +name: kinase binding +namespace: molecular_function +def: "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0019901 +name: protein kinase binding +namespace: molecular_function +def: "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] +is_a: GO:0019900 ! kinase binding + [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process -def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, ISBN:0387520546, Wikipedia:Sexual_reproduction] -comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. +def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] +comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction -is_a: GO:0044703 ! multi-organism reproductive process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22929 xsd:anyURI [Term] id: GO:0021501 @@ -51642,7 +81890,7 @@ synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization -is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of UBERON:0003052 ! midbrain-hindbrain boundary relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization @@ -51806,6 +82054,18 @@ intersection_of: results_in_formation_of UBERON:0002028 ! hindbrain relationship: part_of GO:0021575 ! hindbrain morphogenesis relationship: results_in_formation_of UBERON:0002028 ! hindbrain +[Term] +id: GO:0021578 +name: hindbrain maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0002028 ! hindbrain +relationship: part_of GO:0021626 ! central nervous system maturation +relationship: part_of GO:0030902 ! hindbrain development +relationship: results_in_maturation_of UBERON:0002028 ! hindbrain + [Term] id: GO:0021579 name: medulla oblongata morphogenesis @@ -51836,6 +82096,20 @@ relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021579 ! medulla oblongata morphogenesis relationship: results_in_formation_of UBERON:0001896 ! medulla oblongata +[Term] +id: GO:0021582 +name: medulla oblongata maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla maturation" RELATED [] +synonym: "myelencephalon maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001896 ! medulla oblongata +relationship: part_of GO:0021550 ! medulla oblongata development +relationship: part_of GO:0021578 ! hindbrain maturation +relationship: results_in_maturation_of UBERON:0001896 ! medulla oblongata + [Term] id: GO:0021583 name: pons morphogenesis @@ -51860,6 +82134,18 @@ relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021583 ! pons morphogenesis relationship: results_in_formation_of UBERON:0000988 ! pons +[Term] +id: GO:0021586 +name: pons maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0000988 ! pons +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021578 ! hindbrain maturation +relationship: results_in_maturation_of UBERON:0000988 ! pons + [Term] id: GO:0021587 name: cerebellum morphogenesis @@ -51922,6 +82208,30 @@ intersection_of: results_in_formation_of UBERON:0001785 ! cranial nerve relationship: part_of GO:0021602 ! cranial nerve morphogenesis relationship: results_in_formation_of UBERON:0001785 ! cranial nerve +[Term] +id: GO:0021605 +name: cranial nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0021682 ! nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001785 ! cranial nerve +relationship: part_of GO:0021545 ! cranial nerve development +relationship: results_in_maturation_of UBERON:0001785 ! cranial nerve + +[Term] +id: GO:0021606 +name: accessory nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XI maturation" RELATED [] +synonym: "spinal accessory nerve maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0002019 ! accessory XI nerve +relationship: part_of GO:0021565 ! accessory nerve development +relationship: results_in_maturation_of UBERON:0002019 ! accessory XI nerve + [Term] id: GO:0021607 name: accessory nerve morphogenesis @@ -51947,6 +82257,18 @@ intersection_of: results_in_formation_of UBERON:0002019 ! accessory XI nerve relationship: part_of GO:0021607 ! accessory nerve morphogenesis relationship: results_in_formation_of UBERON:0002019 ! accessory XI nerve +[Term] +id: GO:0021614 +name: glossopharyngeal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001649 ! glossopharyngeal nerve +relationship: part_of GO:0021563 ! glossopharyngeal nerve development +relationship: results_in_maturation_of UBERON:0001649 ! glossopharyngeal nerve + [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis @@ -51984,6 +82306,18 @@ intersection_of: results_in_morphogenesis_of UBERON:0001650 ! hypoglossal nerve relationship: part_of GO:0021566 ! hypoglossal nerve development relationship: results_in_morphogenesis_of UBERON:0001650 ! hypoglossal nerve +[Term] +id: GO:0021619 +name: hypoglossal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001650 ! hypoglossal nerve +relationship: part_of GO:0021566 ! hypoglossal nerve development +relationship: results_in_maturation_of UBERON:0001650 ! hypoglossal nerve + [Term] id: GO:0021620 name: hypoglossal nerve formation @@ -51997,6 +82331,29 @@ intersection_of: results_in_formation_of UBERON:0001650 ! hypoglossal nerve relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis relationship: results_in_formation_of UBERON:0001650 ! hypoglossal nerve +[Term] +id: GO:0021626 +name: central nervous system maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001017 ! central nervous system +relationship: part_of GO:0007417 ! central nervous system development +relationship: results_in_maturation_of UBERON:0001017 ! central nervous system + +[Term] +id: GO:0021635 +name: trigeminal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001645 ! trigeminal nerve +relationship: part_of GO:0021559 ! trigeminal nerve development +relationship: results_in_maturation_of UBERON:0001645 ! trigeminal nerve + [Term] id: GO:0021636 name: trigeminal nerve morphogenesis @@ -52022,6 +82379,18 @@ intersection_of: results_in_formation_of UBERON:0001645 ! trigeminal nerve relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis relationship: results_in_formation_of UBERON:0001645 ! trigeminal nerve +[Term] +id: GO:0021643 +name: vagus nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001759 ! vagus nerve +relationship: part_of GO:0021564 ! vagus nerve development +relationship: results_in_maturation_of UBERON:0001759 ! vagus nerve + [Term] id: GO:0021644 name: vagus nerve morphogenesis @@ -52069,6 +82438,17 @@ intersection_of: results_in_development_of UBERON:0001021 ! nerve relationship: part_of GO:0007399 ! nervous system development relationship: results_in_development_of UBERON:0001021 ! nerve +[Term] +id: GO:0021682 +name: nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001021 ! nerve +relationship: part_of GO:0021675 ! nerve development +relationship: results_in_maturation_of UBERON:0001021 ! nerve + [Term] id: GO:0021700 name: developmental maturation @@ -52114,6 +82494,18 @@ relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021704 ! locus ceruleus morphogenesis relationship: results_in_formation_of UBERON:0002148 ! locus ceruleus +[Term] +id: GO:0021706 +name: locus ceruleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0002148 ! locus ceruleus +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021703 ! locus ceruleus development +relationship: results_in_maturation_of UBERON:0002148 ! locus ceruleus + [Term] id: GO:0021718 name: superior olivary nucleus development @@ -52151,6 +82543,32 @@ relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis relationship: results_in_formation_of UBERON:0007247 ! nucleus of superior olivary complex +[Term] +id: GO:0021722 +name: superior olivary nucleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "superior olive maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0007247 ! nucleus of superior olivary complex +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021718 ! superior olivary nucleus development +relationship: results_in_maturation_of UBERON:0007247 ! nucleus of superior olivary complex + +[Term] +id: GO:0021732 +name: midbrain-hindbrain boundary maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +synonym: "isthmus maturation" RELATED [] +synonym: "MHB maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0003052 ! midbrain-hindbrain boundary +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development +relationship: results_in_maturation_of UBERON:0003052 ! midbrain-hindbrain boundary + [Term] id: GO:0021743 name: hypoglossal nucleus development @@ -52331,8 +82749,8 @@ id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] -is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0048856 ! anatomical structure development +is_a: GO:0048859 ! formation of anatomical boundary intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: results_in_formation_of UBERON:0005075 ! forebrain-midbrain boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning @@ -52565,9 +82983,9 @@ namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0022030 ! telencephalon glial cell migration intersection_of: GO:0016477 ! cell migration +intersection_of: has_primary_input CL:0000128 ! oligodendrocyte intersection_of: results_in_transport_to_from_or_in UBERON:0001893 ! telencephalon -intersection_of: transports_or_maintains_localization_of CL:0000128 ! oligodendrocyte -relationship: transports_or_maintains_localization_of CL:0000128 ! oligodendrocyte +relationship: has_primary_input CL:0000128 ! oligodendrocyte [Term] id: GO:0022035 @@ -52750,6 +83168,8 @@ is_a: GO:0022414 ! reproductive process is_a: GO:0048511 ! rhythmic process intersection_of: GO:0008150 ! biological_process intersection_of: part_of GO:0042698 ! ovulation cycle +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of GO:0042698 ! ovulation cycle [Term] @@ -52801,15 +83221,6 @@ intersection_of: results_in_assembly_of GO:0005575 ! cellular_component relationship: part_of GO:0044085 ! cellular component biogenesis relationship: results_in_assembly_of GO:0005575 ! cellular_component -[Term] -id: GO:0022610 -name: biological adhesion -namespace: biological_process -def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] -subset: goslim_pir -is_a: GO:0008150 ! biological_process -disjoint_from: GO:0044848 ! biological phase - [Term] id: GO:0022612 name: gland morphogenesis @@ -52857,6 +83268,107 @@ intersection_of: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis relationship: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex +[Term] +id: GO:0022626 +name: cytosolic ribosome +def: "A ribosome located in the cytosol." [] +synonym: "70S ribosome" NARROW [] +synonym: "80S ribosome" NARROW [] +is_a: GO:0000313 ! organellar ribosome +intersection_of: GO:0005840 ! ribosome +intersection_of: part_of GO:0005829 ! cytosol +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0022804 +name: active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +synonym: "active carrier activity" EXACT [] +synonym: "carrier activity" EXACT [] +synonym: "permease activity" EXACT [] +synonym: "pump activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022853 +name: active ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022804 ! active transmembrane transporter activity +intersection_of: GO:0022804 ! active transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24870 ! ion + +[Term] +id: GO:0022857 +name: transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005386 +alt_id: GO:0015563 +alt_id: GO:0015646 +alt_id: GO:0022891 +alt_id: GO:0022892 +def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "substrate-specific transmembrane transporter activity" RELATED [] +synonym: "substrate-specific transporter activity" RELATED [] +synonym: "uptake permease activity" RELATED [] +synonym: "uptake transmembrane transporter activity" RELATED [] +xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" +xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" +xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" +xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" +xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" +xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" +is_a: GO:0005215 ! transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: part_of GO:0055085 ! transmembrane transport +relationship: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0022884 +name: macromolecule transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33694 ! biomacromolecule +relationship: has_primary_input CHEBI:33694 ! biomacromolecule + +[Term] +id: GO:0022890 +name: inorganic cation transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015077 +alt_id: GO:0015082 +alt_id: GO:0072509 +alt_id: GO:0072510 +def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] +synonym: "divalent inorganic cation transmembrane transporter activity" NARROW [] +synonym: "monovalent inorganic cation transmembrane transporter activity" NARROW [] +synonym: "trivalent inorganic cation transmembrane transporter activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:36915 ! inorganic cation +relationship: has_primary_input CHEBI:36915 ! inorganic cation + +[Term] +id: GO:0022898 +name: regulation of transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0034762 ! regulation of transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0022857 ! transmembrane transporter activity +relationship: regulates GO:0022857 ! transmembrane transporter activity + [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression @@ -52918,6 +83430,7 @@ subset: goslim_generic subset: goslim_mouse subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] @@ -52973,13 +83486,19 @@ id: GO:0030001 name: metal ion transport namespace: biological_process alt_id: GO:0070838 +alt_id: GO:0070839 def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "divalent metal ion export" NARROW [] synonym: "divalent metal ion transport" NARROW [] synonym: "heavy metal ion transport" NARROW [] +synonym: "metal ion export" NARROW [] is_a: GO:0006812 ! cation transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:25213 ! metal cation -relationship: transports_or_maintains_localization_of CHEBI:25213 ! metal cation +intersection_of: has_primary_input CHEBI:25213 ! metal cation +relationship: has_primary_input CHEBI:25213 ! metal cation +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23033 xsd:anyURI +created_by: mah +creation_date: 2009-07-31T01:07:46Z [Term] id: GO:0030002 @@ -53011,6 +83530,17 @@ is_a: GO:0055067 ! monovalent inorganic cation homeostasis intersection_of: GO:0019725 ! cellular homeostasis intersection_of: regulates_levels_of CHEBI:60242 ! monovalent inorganic cation +[Term] +id: GO:0030010 +name: establishment of cell polarity +namespace: biological_process +alt_id: GO:0000283 +alt_id: GO:0030468 +def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +synonym: "bud site selection/establishment of cell polarity" NARROW [] +synonym: "cell polarization" EXACT [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + [Term] id: GO:0030016 name: myofibril @@ -53051,12 +83581,16 @@ namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process +intersection_of: GO:0009987 ! cellular process +intersection_of: process_has_causal_agent GO:0005884 ! actin filament +relationship: process_has_causal_agent GO:0005884 ! actin filament [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] +subset: prokaryote_subset synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] @@ -53078,6 +83612,18 @@ intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0042995 ! cell projection relationship: results_in_assembly_of GO:0042995 ! cell projection +[Term] +id: GO:0030033 +name: microvillus assembly +namespace: biological_process +def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] +synonym: "microvillus biogenesis" RELATED [GOC:mah] +is_a: GO:0032528 ! microvillus organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly +intersection_of: GO:0022607 ! cellular component assembly +intersection_of: results_in_assembly_of GO:0005902 ! microvillus +relationship: results_in_assembly_of GO:0005902 ! microvillus + [Term] id: GO:0030036 name: actin cytoskeleton organization @@ -53092,14 +83638,15 @@ is_a: GO:0030029 ! actin filament-based process intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0015629 ! actin cytoskeleton relationship: results_in_organization_of GO:0015629 ! actin cytoskeleton +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23114 xsd:anyURI [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] -is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0030029 ! actin filament-based process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0030049 @@ -53109,6 +83656,18 @@ def: "The sliding of actin thin filaments and myosin thick filaments past each o is_a: GO:0033275 ! actin-myosin filament sliding relationship: part_of GO:0006936 ! muscle contraction +[Term] +id: GO:0030050 +name: vesicle transport along actin filament +namespace: biological_process +def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0099515 ! actin filament-based transport +is_a: GO:0099518 ! vesicle cytoskeletal trafficking +intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input GO:0031982 ! vesicle +intersection_of: results_in_transport_along GO:0005884 ! actin filament + [Term] id: GO:0030054 name: cell junction @@ -53141,8 +83700,8 @@ def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:25905 ! peptide hormone -relationship: transports_or_maintains_localization_of CHEBI:25905 ! peptide hormone +intersection_of: has_primary_input CHEBI:25905 ! peptide hormone +relationship: has_primary_input CHEBI:25905 ! peptide hormone [Term] id: GO:0030073 @@ -53151,6 +83710,11 @@ namespace: biological_process def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion +intersection_of: GO:0046903 ! secretion +intersection_of: has_primary_input PR:000009054 ! insulin gene translation product +relationship: has_primary_input PR:000009054 ! insulin gene translation product +relationship: in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 xsd:anyURI [Term] @@ -53274,6 +83838,38 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007155 ! cell adhesion relationship: regulates GO:0007155 ! cell adhesion +[Term] +id: GO:0030163 +name: protein catabolic process +namespace: biological_process +alt_id: GO:0044254 +alt_id: GO:0044257 +def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] +comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +subset: prokaryote_subset +synonym: "cellular protein breakdown" EXACT [] +synonym: "cellular protein catabolic process" EXACT [] +synonym: "cellular protein catabolism" EXACT [] +synonym: "cellular protein degradation" EXACT [] +synonym: "multicellular organismal protein catabolic process" NARROW [] +synonym: "pheromone catabolic process" RELATED [] +synonym: "pheromone catabolism" RELATED [] +synonym: "protein breakdown" EXACT [] +synonym: "protein catabolism" EXACT [] +synonym: "protein degradation" EXACT [] +xref: Wikipedia:Protein_catabolism +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0019538 ! protein metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input PR:000000001 ! protein +relationship: has_primary_input PR:000000001 ! protein +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI + [Term] id: GO:0030168 name: platelet activation @@ -53283,6 +83879,18 @@ synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation +[Term] +id: GO:0030173 +name: integral component of Golgi membrane +namespace: cellular_component +def: "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] +synonym: "Golgi integral membrane protein" RELATED [] +synonym: "integral to Golgi membrane" NARROW [] +is_a: GO:0031228 ! intrinsic component of Golgi membrane +is_a: GO:0031301 ! integral component of organelle membrane +intersection_of: GO:0016021 ! integral component of membrane +intersection_of: part_of GO:0000139 ! Golgi membrane + [Term] id: GO:0030176 name: integral component of endoplasmic reticulum membrane @@ -53321,6 +83929,28 @@ synonym: "B-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation +[Term] +id: GO:0030186 +name: melatonin metabolic process +def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [] +synonym: "melatonin metabolism" EXACT [] +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0030187 +name: melatonin biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [] +synonym: "melatonin anabolism" EXACT [] +synonym: "melatonin biosynthesis" EXACT [] +synonym: "melatonin formation" EXACT [] +synonym: "melatonin synthesis" EXACT [] +is_a: GO:0030186 ! melatonin metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + [Term] id: GO:0030193 name: regulation of blood coagulation @@ -53399,6 +84029,15 @@ intersection_of: results_in_organization_of GO:0098643 ! banded collagen fibril relationship: results_in_organization_of GO:0098643 ! banded collagen fibril property_value: RO:0002161 NCBITaxon:4751 +[Term] +id: GO:0030202 +name: heparin metabolic process +def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [] +synonym: "heparan sulfate metabolic process" RELATED [] +synonym: "heparin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1903510 ! mucopolysaccharide metabolic process + [Term] id: GO:0030203 name: glycosaminoglycan metabolic process @@ -53410,6 +84049,19 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:18085 ! glycosaminoglycan relationship: has_primary_input_or_output CHEBI:18085 ! glycosaminoglycan +[Term] +id: GO:0030210 +name: heparin biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [] +synonym: "heparan sulfate biosynthetic process" RELATED [] +synonym: "heparin anabolism" EXACT [] +synonym: "heparin biosynthesis" EXACT [] +synonym: "heparin formation" EXACT [] +synonym: "heparin synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030202 ! heparin metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + [Term] id: GO:0030212 name: hyaluronan metabolic process @@ -53436,6 +84088,20 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:16336 ! hyaluronic acid relationship: has_primary_output CHEBI:16336 ! hyaluronic acid +[Term] +id: GO:0030214 +name: hyaluronan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] +synonym: "hyaluronan breakdown" EXACT [] +synonym: "hyaluronan catabolism" EXACT [] +synonym: "hyaluronan degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030212 ! hyaluronan metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:16336 ! hyaluronic acid +relationship: has_primary_input CHEBI:16336 ! hyaluronic acid + [Term] id: GO:0030216 name: keratinocyte differentiation @@ -53493,6 +84159,13 @@ intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000556 ! megakaryocyte relationship: results_in_acquisition_of_features_of CL:0000556 ! megakaryocyte +[Term] +id: GO:0030221 +name: basophil differentiation +def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [] +synonym: "basophil cell differentiation" EXACT [] +is_a: GO:0030851 ! granulocyte differentiation + [Term] id: GO:0030223 name: neutrophil differentiation @@ -53529,6 +84202,30 @@ intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000235 ! macrophage relationship: results_in_acquisition_of_features_of CL:0000235 ! macrophage +[Term] +id: GO:0030234 +name: enzyme regulator activity +namespace: molecular_function +alt_id: GO:0010576 +def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +subset: goslim_agr +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "catalytic regulator activity" EXACT [GOC:dph] +synonym: "enzyme modulator" EXACT [] +synonym: "metalloenzyme regulator activity" NARROW [] +is_a: GO:0098772 ! molecular function regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: regulates GO:0003824 ! catalytic activity +relationship: part_of GO:0050790 ! regulation of catalytic activity +relationship: regulates GO:0003824 ! catalytic activity + [Term] id: GO:0030239 name: myofibril assembly @@ -53599,7 +84296,7 @@ def: "The progressive compaction of dispersed interphase chromatin into threadli synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] -is_a: GO:0006323 ! DNA packaging +is_a: GO:0051276 ! chromosome organization [Term] id: GO:0030262 @@ -53678,6 +84375,63 @@ def: "Any of several large complexes that contain two or three dynein heavy chai is_a: GO:0005875 ! microtubule associated complex is_a: GO:1902494 ! catalytic complex +[Term] +id: GO:0030292 +name: protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0004713 ! protein tyrosine kinase activity +relationship: negatively_regulates GO:0004713 ! protein tyrosine kinase activity +relationship: part_of GO:0061099 ! negative regulation of protein tyrosine kinase activity + +[Term] +id: GO:0030293 +name: transmembrane receptor protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] +is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity +is_a: GO:0030547 ! signaling receptor inhibitor activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +relationship: negatively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0030295 +name: protein kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019209 ! kinase activator activity +is_a: GO:0019887 ! protein kinase regulator activity +intersection_of: GO:0003674 ! molecular_function +intersection_of: positively_regulates GO:0004672 ! protein kinase activity +relationship: part_of GO:0032147 ! activation of protein kinase activity +relationship: positively_regulates GO:0004672 ! protein kinase activity + +[Term] +id: GO:0030296 +name: protein tyrosine kinase activator activity +namespace: molecular_function +def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732] +is_a: GO:0030295 ! protein kinase activator activity +intersection_of: GO:0003674 ! molecular_function +intersection_of: positively_regulates GO:0004713 ! protein tyrosine kinase activity +relationship: part_of GO:0061098 ! positive regulation of protein tyrosine kinase activity +relationship: positively_regulates GO:0004713 ! protein tyrosine kinase activity + +[Term] +id: GO:0030297 +name: transmembrane receptor protein tyrosine kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] +is_a: GO:0030296 ! protein tyrosine kinase activator activity +is_a: GO:0030546 ! signaling receptor activator activity +intersection_of: GO:0003674 ! molecular_function +intersection_of: positively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +relationship: part_of GO:0007171 ! activation of transmembrane receptor protein tyrosine kinase activity +relationship: positively_regulates GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + [Term] id: GO:0030299 name: intestinal cholesterol absorption @@ -53917,7 +84671,6 @@ namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast @@ -54092,6 +84845,105 @@ synonym: "female genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0046660 ! female sex differentiation +[Term] +id: GO:0030545 +name: signaling receptor regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a receptor." [GOC:ceb] +synonym: "receptor regulator activity" BROAD [] +is_a: GO:0098772 ! molecular function regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: regulates GO:0038023 ! signaling receptor activity +relationship: regulates GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0030546 +name: signaling receptor activator activity +namespace: molecular_function +def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] +synonym: "receptor activator activity" BROAD [] +synonym: "signalling receptor activator activity" EXACT [] +is_a: GO:0030545 ! signaling receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: positively_regulates GO:0038023 ! signaling receptor activity +relationship: positively_regulates GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0030547 +name: signaling receptor inhibitor activity +namespace: molecular_function +def: "Binds to and modulates the activity of a signaling receptor." [GOC:ceb] +synonym: "receptor inhibitor activity" BROAD [] +is_a: GO:0030545 ! signaling receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0038023 ! signaling receptor activity +relationship: negatively_regulates GO:0038023 ! signaling receptor activity +relationship: part_of GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0030548 +name: acetylcholine receptor regulator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] +is_a: GO:0099602 ! neurotransmitter receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: regulates GO:0015464 ! acetylcholine receptor activity +relationship: regulates GO:0015464 ! acetylcholine receptor activity + +[Term] +id: GO:0030549 +name: acetylcholine receptor activator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] +is_a: GO:0030546 ! signaling receptor activator activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: positively_regulates GO:0015464 ! acetylcholine receptor activity +relationship: positively_regulates GO:0015464 ! acetylcholine receptor activity + +[Term] +id: GO:0030550 +name: acetylcholine receptor inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of an acetylcholine receptor." [GOC:mah] +is_a: GO:0030547 ! signaling receptor inhibitor activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: negatively_regulates GO:0015464 ! acetylcholine receptor activity +relationship: negatively_regulates GO:0015464 ! acetylcholine receptor activity + +[Term] +id: GO:0030573 +name: bile acid catabolic process +namespace: biological_process +alt_id: GO:0019613 +def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] +synonym: "bile acid breakdown" EXACT [] +synonym: "bile acid catabolism" EXACT [] +synonym: "bile acid degradation" EXACT [] +synonym: "cholate catabolic process" NARROW [] +xref: MetaCyc:7ALPHADEHYDROX-PWY +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:36235 ! bile acid anion +relationship: has_primary_input CHEBI:36235 ! bile acid anion + +[Term] +id: GO:0030574 +name: collagen catabolic process +namespace: biological_process +def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] +synonym: "collagen breakdown" EXACT [] +synonym: "collagen catabolism" EXACT [] +synonym: "collagen degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0032963 ! collagen metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input GO:0005581 ! collagen trimer +relationship: has_primary_input GO:0005581 ! collagen trimer + [Term] id: GO:0030593 name: neutrophil chemotaxis @@ -54240,6 +85092,28 @@ intersection_of: GO:0046907 ! intracellular transport intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber relationship: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber +[Term] +id: GO:0030720 +name: oocyte localization involved in germarium-derived egg chamber formation +namespace: biological_process +def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] +synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] +synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] +synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] +synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte localization during oogenesis" RELATED [] +synonym: "oocyte positioning during oogenesis" NARROW [] +synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] +synonym: "oogenesis, oocyte localization" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051674 ! localization of cell +intersection_of: GO:0051179 ! localization +intersection_of: has_primary_input CL:0000023 ! oocyte +relationship: has_primary_input CL:0000023 ! oocyte +relationship: in_taxon NCBITaxon:50557 ! Insecta +relationship: only_in_taxon NCBITaxon:50557 ! Insecta +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + [Term] id: GO:0030728 name: ovulation @@ -54249,6 +85123,59 @@ xref: Wikipedia:Ovulation is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007292 ! female gamete generation +[Term] +id: GO:0030808 +name: regulation of nucleotide biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [] +synonym: "regulation of nucleotide anabolism" EXACT [] +synonym: "regulation of nucleotide biosynthesis" EXACT [] +synonym: "regulation of nucleotide formation" EXACT [] +synonym: "regulation of nucleotide synthesis" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0009165 ! nucleotide biosynthetic process +relationship: regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030809 +name: negative regulation of nucleotide biosynthetic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [] +synonym: "down regulation of nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of nucleotide biosynthetic process" EXACT [] +synonym: "inhibition of nucleotide biosynthetic process" NARROW [] +synonym: "negative regulation of nucleotide anabolism" EXACT [] +synonym: "negative regulation of nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of nucleotide formation" EXACT [] +synonym: "negative regulation of nucleotide synthesis" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0009165 ! nucleotide biosynthetic process +relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030810 +name: positive regulation of nucleotide biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [] +synonym: "activation of nucleotide biosynthetic process" NARROW [] +synonym: "positive regulation of nucleotide anabolism" EXACT [] +synonym: "positive regulation of nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of nucleotide formation" EXACT [] +synonym: "positive regulation of nucleotide synthesis" EXACT [] +synonym: "stimulation of nucleotide biosynthetic process" NARROW [] +synonym: "up regulation of nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of nucleotide biosynthetic process" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0009165 ! nucleotide biosynthetic process +relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process + [Term] id: GO:0030851 name: granulocyte differentiation @@ -54555,6 +85482,35 @@ relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning relationship: results_in_development_of UBERON:0003052 ! midbrain-hindbrain boundary +[Term] +id: GO:0030936 +name: transmembrane collagen trimer +namespace: cellular_component +def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] +synonym: "MACIT" EXACT [ISBN:0198599587] +is_a: GO:0005581 ! collagen trimer +is_a: GO:0098797 ! plasma membrane protein complex +intersection_of: GO:0005581 ! collagen trimer +intersection_of: part_of GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0030951 +name: establishment or maintenance of microtubule cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity + +[Term] +id: GO:0030952 +name: establishment or maintenance of cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] +synonym: "cytoskeleton polarization" RELATED [] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0007163 ! establishment or maintenance of cell polarity + [Term] id: GO:0030990 name: intraciliary transport particle @@ -54578,6 +85534,7 @@ subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir +subset: prokaryote_subset synonym: "matrisome" NARROW [] synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 @@ -54593,6 +85550,46 @@ namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001264 ! pancreas +relationship: results_in_development_of UBERON:0001264 ! pancreas + +[Term] +id: GO:0031017 +name: exocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] +is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0000017 ! exocrine pancreas +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035272 ! exocrine system development +relationship: part_of GO:0055123 ! digestive system development +relationship: results_in_development_of UBERON:0000017 ! exocrine pancreas + +[Term] +id: GO:0031018 +name: endocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] +is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0000016 ! endocrine pancreas +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035270 ! endocrine system development +relationship: results_in_development_of UBERON:0000016 ! endocrine pancreas + +[Term] +id: GO:0031022 +name: nuclear migration along microfilament +namespace: biological_process +def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] +synonym: "nuclear migration, microfilament-mediated" EXACT [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0099515 ! actin filament-based transport +intersection_of: GO:0007097 ! nuclear migration +intersection_of: results_in_transport_along GO:0005884 ! actin filament [Term] id: GO:0031032 @@ -54612,19 +85609,20 @@ relationship: results_in_organization_of GO:0042641 ! actomyosin id: GO:0031049 name: programmed DNA elimination namespace: biological_process -def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] +def: "A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing." [GOC:mah, GOC:ns, PMID:18708581, PMID:24886889, PMID:32986476] subset: goslim_pir -is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0040029 ! epigenetic regulation of gene expression +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22815 xsd:anyURI [Term] id: GO:0031052 -name: chromosome breakage +name: programmed DNA elimination by chromosome breakage namespace: biological_process -def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] -comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. -synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] -is_a: GO:0051276 ! chromosome organization -relationship: part_of GO:0031049 ! programmed DNA elimination +def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns, PMID:15956677, PMID:25303953, PMID:32165395] +comment: Note that this term refers to breakage of chromosomes during normal DNA well characterized in ciliates but also present in many vertebrates; it is not to be used for DNA damage or other abnormal occurrences. +synonym: "chromosome breakage" RELATED [] +is_a: GO:0031049 ! programmed DNA elimination +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22815 xsd:anyURI [Term] id: GO:0031069 @@ -54946,6 +85944,17 @@ intersection_of: GO:0031224 ! intrinsic component of membrane intersection_of: part_of GO:0005789 ! endoplasmic reticulum membrane relationship: part_of GO:0005789 ! endoplasmic reticulum membrane +[Term] +id: GO:0031228 +name: intrinsic component of Golgi membrane +namespace: cellular_component +def: "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to Golgi membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +intersection_of: GO:0031224 ! intrinsic component of membrane +intersection_of: part_of GO:0000139 ! Golgi membrane +relationship: part_of GO:0000139 ! Golgi membrane + [Term] id: GO:0031252 name: cell leading edge @@ -55103,6 +86112,28 @@ is_a: GO:0032592 ! integral component of mitochondrial membrane intersection_of: GO:0016021 ! integral component of membrane intersection_of: part_of GO:0005743 ! mitochondrial inner membrane +[Term] +id: GO:0031308 +name: intrinsic component of nuclear outer membrane +namespace: cellular_component +def: "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to nuclear outer membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +intersection_of: GO:0031224 ! intrinsic component of membrane +intersection_of: part_of GO:0005640 ! nuclear outer membrane +relationship: part_of GO:0005640 ! nuclear outer membrane + +[Term] +id: GO:0031309 +name: integral component of nuclear outer membrane +namespace: cellular_component +def: "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to nuclear outer membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0031308 ! intrinsic component of nuclear outer membrane +intersection_of: GO:0016021 ! integral component of membrane +intersection_of: part_of GO:0005640 ! nuclear outer membrane + [Term] id: GO:0031310 name: intrinsic component of vacuolar membrane @@ -55582,7 +86613,9 @@ def: "Any process that modulates the frequency, rate or extent of the covalent a subset: goslim_yeast is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation +intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006464 ! cellular protein modification process +intersection_of: regulates GO:0036211 ! protein modification process relationship: regulates GO:0006464 ! cellular protein modification process [Term] @@ -55597,7 +86630,9 @@ synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation +intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process +intersection_of: negatively_regulates GO:0036211 ! protein modification process relationship: negatively_regulates GO:0006464 ! cellular protein modification process [Term] @@ -55613,9 +86648,22 @@ synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation +intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006464 ! cellular protein modification process +intersection_of: positively_regulates GO:0036211 ! protein modification process relationship: positively_regulates GO:0006464 ! cellular protein modification process +[Term] +id: GO:0031402 +name: sodium ion binding +namespace: molecular_function +def: "Binding to a sodium ion (Na+)." [GOC:mah] +synonym: "Na+ ion binding" EXACT [] +is_a: GO:0031420 ! alkali metal ion binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:29101 ! sodium(1+) +relationship: has_input CHEBI:29101 ! sodium(1+) + [Term] id: GO:0031406 name: carboxylic acid binding @@ -55634,7 +86682,6 @@ namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic @@ -55649,6 +86696,23 @@ intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm +[Term] +id: GO:0031420 +name: alkali metal ion binding +namespace: molecular_function +def: "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] +is_a: GO:0046872 ! metal ion binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:33504 ! alkali metal cation +relationship: has_input CHEBI:33504 ! alkali metal cation + +[Term] +id: GO:0031424 +name: keratinization +def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0030216 ! keratinocyte differentiation + [Term] id: GO:0031430 name: M band @@ -55663,82 +86727,6 @@ is_a: CARO:0000000 ! anatomical entity is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0031672 ! A band -[Term] -id: GO:0031445 -name: regulation of heterochromatin assembly -namespace: biological_process -def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] -synonym: "regulation of heterochromatin formation" EXACT [] -is_a: GO:0010468 ! regulation of gene expression -is_a: GO:0010847 ! regulation of chromatin assembly -is_a: GO:0120261 ! regulation of heterochromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0031507 ! heterochromatin assembly -relationship: regulates GO:0031507 ! heterochromatin assembly - -[Term] -id: GO:0031452 -name: negative regulation of heterochromatin assembly -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] -synonym: "down regulation of heterochromatin formation" EXACT [] -synonym: "down-regulation of heterochromatin formation" EXACT [] -synonym: "downregulation of heterochromatin formation" EXACT [] -synonym: "inhibition of heterochromatin formation" NARROW [] -synonym: "negative regulation of heterochromatin formation" EXACT [] -is_a: GO:0010628 ! positive regulation of gene expression -is_a: GO:0031445 ! regulation of heterochromatin assembly -is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly -is_a: GO:0120262 ! negative regulation of heterochromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0031507 ! heterochromatin assembly -relationship: negatively_regulates GO:0031507 ! heterochromatin assembly - -[Term] -id: GO:0031453 -name: positive regulation of heterochromatin assembly -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] -synonym: "activation of heterochromatin formation" NARROW [] -synonym: "positive regulation of heterochromatin formation" EXACT [] -synonym: "stimulation of heterochromatin formation" NARROW [] -synonym: "up regulation of heterochromatin formation" EXACT [] -synonym: "up-regulation of heterochromatin formation" EXACT [] -synonym: "upregulation of heterochromatin formation" EXACT [] -is_a: GO:0031445 ! regulation of heterochromatin assembly -is_a: GO:0044089 ! positive regulation of cellular component biogenesis -is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly -is_a: GO:0120263 ! positive regulation of heterochromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0031507 ! heterochromatin assembly -relationship: positively_regulates GO:0031507 ! heterochromatin assembly - -[Term] -id: GO:0031497 -name: chromatin assembly -namespace: biological_process -def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] -synonym: "chromatin maintenance" BROAD [] -synonym: "establishment of chromatin architecture" EXACT [GOC:mah] -is_a: GO:0006333 ! chromatin assembly or disassembly -is_a: GO:0022607 ! cellular component assembly -intersection_of: GO:0022607 ! cellular component assembly -intersection_of: results_in_assembly_of GO:0000785 ! chromatin -relationship: part_of GO:0006323 ! DNA packaging -relationship: results_in_assembly_of GO:0000785 ! chromatin - -[Term] -id: GO:0031498 -name: chromatin disassembly -namespace: biological_process -def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] -synonym: "chromatin maintenance" BROAD [] -is_a: GO:0006333 ! chromatin assembly or disassembly -is_a: GO:0022411 ! cellular component disassembly -intersection_of: GO:0022411 ! cellular component disassembly -intersection_of: results_in_disassembly_of GO:0000785 ! chromatin -relationship: results_in_disassembly_of GO:0000785 ! chromatin - [Term] id: GO:0031503 name: protein-containing complex localization @@ -55754,49 +86742,10 @@ synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0032991 ! protein-containing complex -relationship: transports_or_maintains_localization_of GO:0032991 ! protein-containing complex +intersection_of: has_primary_input GO:0032991 ! protein-containing complex +relationship: has_primary_input GO:0032991 ! protein-containing complex property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22021 xsd:anyURI -[Term] -id: GO:0031507 -name: heterochromatin assembly -namespace: biological_process -alt_id: GO:0006342 -alt_id: GO:0006343 -alt_id: GO:0016440 -alt_id: GO:0070869 -alt_id: GO:1904497 -def: "An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [GOC:mah, PMID:25192661, PMID:33827924] -synonym: "chromatin silencing" EXACT [] -synonym: "chromatin-mediated silencing" EXACT [] -synonym: "establishment of chromatin silencing" RELATED [] -synonym: "establishment of heterochromatic silencing" RELATED [] -synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] -synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] -synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] -synonym: "heterochromatic silencing" RELATED [] -synonym: "heterochromatin assembly involved in chromatin silencing" RELATED [] -synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW [] -synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] -synonym: "heterochromatin formation" EXACT [] -synonym: "heterochromatin formation involved in chromatin silencing" RELATED [] -synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] -synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] -synonym: "heterochromatin maintenance" BROAD [] -synonym: "TGS" BROAD [] -synonym: "transcriptional gene silencing" EXACT [] -is_a: GO:0031497 ! chromatin assembly -is_a: GO:0045814 ! negative regulation of gene expression, epigenetic -is_a: GO:0070828 ! heterochromatin organization -intersection_of: GO:0022607 ! cellular component assembly -intersection_of: results_in_assembly_of GO:0000792 ! heterochromatin -relationship: ends_with GO:0033696 ! heterochromatin boundary formation -relationship: results_in_assembly_of GO:0000792 ! heterochromatin -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18954 xsd:anyURI -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19112 xsd:anyURI -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22030 xsd:anyURI - [Term] id: GO:0031514 name: motile cilium @@ -56102,6 +87051,94 @@ is_a: CARO:0000000 ! anatomical entity is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0030017 ! sarcomere +[Term] +id: GO:0031943 +name: regulation of glucocorticoid metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [] +synonym: "regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0008211 ! glucocorticoid metabolic process +relationship: regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031944 +name: negative regulation of glucocorticoid metabolic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [] +synonym: "down regulation of glucocorticoid metabolic process" EXACT [] +synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "downregulation of glucocorticoid metabolic process" EXACT [] +synonym: "inhibition of glucocorticoid metabolic process" NARROW [] +synonym: "negative regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0008211 ! glucocorticoid metabolic process +relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031945 +name: positive regulation of glucocorticoid metabolic process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [] +synonym: "activation of glucocorticoid metabolic process" NARROW [] +synonym: "positive regulation of glucocorticoid metabolism" EXACT [] +synonym: "stimulation of glucocorticoid metabolic process" NARROW [] +synonym: "up regulation of glucocorticoid metabolic process" EXACT [] +synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "upregulation of glucocorticoid metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0008211 ! glucocorticoid metabolic process +relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031946 +name: regulation of glucocorticoid biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [] +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006704 ! glucocorticoid biosynthetic process +relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031947 +name: negative regulation of glucocorticoid biosynthetic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [] +synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] +is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process +relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031948 +name: positive regulation of glucocorticoid biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [] +synonym: "activation of glucocorticoid biosynthetic process" NARROW [] +synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] +synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] +is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process +relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process + [Term] id: GO:0031965 name: nuclear membrane @@ -56205,6 +87242,16 @@ is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0043227 ! membrane-bounded organelle relationship: part_of GO:0043229 ! intracellular organelle +[Term] +id: GO:0031987 +name: locomotion involved in locomotory behavior +def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [] +synonym: "locomotion during locomotory behaviour" EXACT [] +is_a: GO:0040011 ! locomotion +intersection_of: GO:0040011 ! locomotion +intersection_of: part_of GO:0007626 ! locomotory behavior +relationship: part_of GO:0007626 ! locomotory behavior + [Term] id: GO:0032024 name: positive regulation of insulin secretion @@ -56236,6 +87283,16 @@ intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion relationship: part_of GO:0000002 ! mitochondrial genome maintenance +[Term] +id: GO:0032052 +name: bile acid binding +namespace: molecular_function +def: "Binding to a bile acid, a steroid carboxylic acids occurring in bile." [GOC:rph] +is_a: GO:0033293 ! monocarboxylic acid binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:36235 ! bile acid anion +relationship: has_input CHEBI:36235 ! bile acid anion + [Term] id: GO:0032055 name: negative regulation of translation in response to stress @@ -56267,6 +87324,37 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: part_of GO:0033554 ! cellular response to stress intersection_of: positively_regulates GO:0006412 ! translation +[Term] +id: GO:0032057 +name: negative regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "down regulation of translation initiation in response to stress" EXACT [] +synonym: "down-regulation of translation initiation in response to stress" EXACT [] +synonym: "downregulation of translation initiation in response to stress" EXACT [] +synonym: "inhibition of translation initiation in response to stress" NARROW [] +is_a: GO:0045947 ! negative regulation of translational initiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006413 ! translational initiation +intersection_of: part_of GO:0006950 ! response to stress +relationship: part_of GO:0006950 ! response to stress + +[Term] +id: GO:0032058 +name: positive regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "activation of translation initiation in response to stress" NARROW [] +synonym: "stimulation of translation initiation in response to stress" NARROW [] +synonym: "up regulation of translation initiation in response to stress" EXACT [] +synonym: "up-regulation of translation initiation in response to stress" EXACT [] +synonym: "upregulation of translation initiation in response to stress" EXACT [] +is_a: GO:0045948 ! positive regulation of translational initiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: part_of GO:0006950 ! response to stress +intersection_of: positively_regulates GO:0006413 ! translational initiation +relationship: part_of GO:0006950 ! response to stress + [Term] id: GO:0032059 name: bleb @@ -56370,6 +87458,14 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009605 ! response to external stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus +[Term] +id: GO:0032147 +name: activation of protein kinase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] +synonym: "protein kinase activation" RELATED [] +is_a: GO:0045860 ! positive regulation of protein kinase activity + [Term] id: GO:0032156 name: septin cytoskeleton @@ -56458,6 +87554,91 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007271 ! synaptic transmission, cholinergic relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic +[Term] +id: GO:0032228 +name: regulation of synaptic transmission, GABAergic +def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051932 ! synaptic transmission, GABAergic +relationship: regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032229 +name: negative regulation of synaptic transmission, GABAergic +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [] +synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] +synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic +relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032230 +name: positive regulation of synaptic transmission, GABAergic +def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [] +synonym: "activation of synaptic transmission, GABAergic" NARROW [] +synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] +synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051932 ! synaptic transmission, GABAergic +relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032231 +name: regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0110053 ! regulation of actin filament organization +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051017 ! actin filament bundle assembly +relationship: regulates GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0032232 +name: negative regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "down regulation of actin filament bundle formation" EXACT [] +synonym: "down-regulation of actin filament bundle formation" EXACT [] +synonym: "downregulation of actin filament bundle formation" EXACT [] +synonym: "inhibition of actin filament bundle formation" NARROW [] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051017 ! actin filament bundle assembly +relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0032233 +name: positive regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "activation of actin filament bundle formation" NARROW [] +synonym: "stimulation of actin filament bundle formation" NARROW [] +synonym: "up regulation of actin filament bundle formation" EXACT [] +synonym: "up-regulation of actin filament bundle formation" EXACT [] +synonym: "upregulation of actin filament bundle formation" EXACT [] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051017 ! actin filament bundle assembly +relationship: positively_regulates GO:0051017 ! actin filament bundle assembly + [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport @@ -56511,14 +87692,13 @@ synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0030141 ! secretory granule -relationship: transports_or_maintains_localization_of GO:0030141 ! secretory granule +intersection_of: has_primary_input GO:0030141 ! secretory granule +relationship: has_primary_input GO:0030141 ! secretory granule [Term] id: GO:0032268 name: regulation of cellular protein metabolic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [] synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process @@ -56529,8 +87709,7 @@ relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] @@ -56546,8 +87725,7 @@ relationship: negatively_regulates GO:0044267 ! cellular protein metabolic proce [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] @@ -56856,6 +88034,21 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042445 ! hormone metabolic process relationship: positively_regulates GO:0042445 ! hormone metabolic process +[Term] +id: GO:0032353 +name: negative regulation of hormone biosynthetic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [] +synonym: "down regulation of hormone biosynthetic process" EXACT [] +synonym: "down-regulation of hormone biosynthetic process" EXACT [] +synonym: "downregulation of hormone biosynthetic process" EXACT [] +synonym: "inhibition of hormone biosynthetic process" NARROW [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0042446 ! hormone biosynthetic process +relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process + [Term] id: GO:0032364 name: oxygen homeostasis @@ -56874,8 +88067,8 @@ def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure -intersection_of: transports_or_maintains_localization_of CHEBI:18059 ! lipid [Term] id: GO:0032366 @@ -57217,8 +88410,8 @@ def: "Any process in which a melanosome is transported to, and/or maintained in, synonym: "melanosome localisation" EXACT [GOC:mah] is_a: GO:0051875 ! pigment granule localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0042470 ! melanosome -relationship: transports_or_maintains_localization_of GO:0042470 ! melanosome +intersection_of: has_primary_input GO:0042470 ! melanosome +relationship: has_primary_input GO:0042470 ! melanosome [Term] id: GO:0032401 @@ -57238,7 +88431,97 @@ is_a: GO:0032400 ! melanosome localization is_a: GO:0032401 ! establishment of melanosome localization is_a: GO:0051904 ! pigment granule transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of GO:0042470 ! melanosome +intersection_of: has_primary_input GO:0042470 ! melanosome + +[Term] +id: GO:0032409 +name: regulation of transporter activity +namespace: biological_process +def: "Any process that modulates the activity of a transporter." [GOC:mah] +is_a: GO:0065009 ! regulation of molecular function +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0005215 ! transporter activity +relationship: regulates GO:0005215 ! transporter activity + +[Term] +id: GO:0032410 +name: negative regulation of transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] +synonym: "down regulation of transporter activity" EXACT [] +synonym: "down-regulation of transporter activity" EXACT [] +synonym: "downregulation of transporter activity" EXACT [] +synonym: "inhibition of transporter activity" NARROW [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0051051 ! negative regulation of transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0005215 ! transporter activity +relationship: negatively_regulates GO:0005215 ! transporter activity + +[Term] +id: GO:0032411 +name: positive regulation of transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of a transporter." [GOC:mah] +synonym: "activation of transporter activity" NARROW [] +synonym: "stimulation of transporter activity" NARROW [] +synonym: "up regulation of transporter activity" EXACT [] +synonym: "up-regulation of transporter activity" EXACT [] +synonym: "upregulation of transporter activity" EXACT [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0051050 ! positive regulation of transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0005215 ! transporter activity +relationship: positively_regulates GO:0005215 ! transporter activity + +[Term] +id: GO:0032412 +name: regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0022898 ! regulation of transmembrane transporter activity +is_a: GO:0034765 ! regulation of ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0015075 ! ion transmembrane transporter activity +relationship: regulates GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0032413 +name: negative regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "down regulation of ion transporter activity" EXACT [] +synonym: "down-regulation of ion transporter activity" EXACT [] +synonym: "downregulation of ion transporter activity" EXACT [] +synonym: "inhibition of ion transporter activity" NARROW [] +synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0015075 ! ion transmembrane transporter activity +relationship: negatively_regulates GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0032414 +name: positive regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "activation of ion transporter activity" NARROW [] +synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] +synonym: "stimulation of ion transporter activity" NARROW [] +synonym: "up regulation of ion transporter activity" EXACT [] +synonym: "up-regulation of ion transporter activity" EXACT [] +synonym: "upregulation of ion transporter activity" EXACT [] +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0015075 ! ion transmembrane transporter activity +relationship: positively_regulates GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0032418 @@ -57248,8 +88531,8 @@ def: "Any process in which a lysosome is transported to, and/or maintained in, a synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:1990849 ! vacuolar localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005764 ! lysosome -relationship: transports_or_maintains_localization_of GO:0005764 ! lysosome +intersection_of: has_primary_input GO:0005764 ! lysosome +relationship: has_primary_input GO:0005764 ! lysosome [Term] id: GO:0032420 @@ -57260,6 +88543,7 @@ is_a: GO:0043005 ! neuron projection is_a: GO:0098858 ! actin-based cell projection relationship: part_of GO:0032421 ! stereocilium bundle relationship: part_of GO:0043226 ! organelle +property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0032421 @@ -57408,7 +88692,6 @@ namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr -subset: goslim_aspergillus subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] @@ -57427,6 +88710,43 @@ subset: goslim_drosophila is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process +[Term] +id: GO:0032528 +name: microvillus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] +synonym: "microvillus organisation" EXACT [GOC:mah] +synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0005902 ! microvillus +relationship: results_in_organization_of GO:0005902 ! microvillus +property_value: RO:0002161 NCBITaxon:4751 + +[Term] +id: GO:0032530 +name: regulation of microvillus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] +synonym: "regulation of microvillus organisation" EXACT [GOC:mah] +synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0032528 ! microvillus organization +relationship: regulates GO:0032528 ! microvillus organization + +[Term] +id: GO:0032534 +name: regulation of microvillus assembly +namespace: biological_process +def: "A process that modulates the formation of a microvillus." [GOC:mah] +synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0030033 ! microvillus assembly +relationship: regulates GO:0030033 ! microvillus assembly + [Term] id: GO:0032535 name: regulation of cellular component size @@ -59175,8 +90495,13 @@ relationship: positively_regulates GO:0004497 ! monooxygenase activity id: GO:0032774 name: RNA biosynthetic process namespace: biological_process +alt_id: GO:0062103 def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. +synonym: "double-stranded RNA biosynthesis" NARROW [] +synonym: "double-stranded RNA biosynthetic process" NARROW [] +synonym: "dsRNA biosynthesis" NARROW [] +synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] @@ -59188,6 +90513,17 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33697 ! ribonucleic acid relationship: has_primary_output CHEBI:33697 ! ribonucleic acid +[Term] +id: GO:0032782 +name: bile acid secretion +namespace: biological_process +def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0046717 ! acid secretion +intersection_of: GO:0046903 ! secretion +intersection_of: has_primary_input CHEBI:36235 ! bile acid anion +relationship: has_primary_input CHEBI:36235 ! bile acid anion + [Term] id: GO:0032787 name: monocarboxylic acid metabolic process @@ -59326,12 +90662,35 @@ is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0030425 ! dendrite relationship: part_of GO:0030425 ! dendrite +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14472 xsd:anyURI + +[Term] +id: GO:0032868 +name: response to insulin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] +synonym: "response to insulin stimulus" EXACT [GOC:dos] +is_a: GO:0043434 ! response to peptide hormone +intersection_of: GO:0042221 ! response to chemical +intersection_of: has_input PR:000009054 ! insulin gene translation product +relationship: has_input PR:000009054 ! insulin gene translation product + +[Term] +id: GO:0032869 +name: cellular response to insulin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] +is_a: GO:0032868 ! response to insulin +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input PR:000009054 ! insulin gene translation product [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] +is_a: GO:0009725 ! response to hormone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus @@ -59345,6 +90704,16 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000741 ! karyogamy relationship: regulates GO:0000741 ! karyogamy +[Term] +id: GO:0032878 +name: regulation of establishment or maintenance of cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity +relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity + [Term] id: GO:0032879 name: regulation of localization @@ -59366,7 +90735,7 @@ subset: goslim_chembl synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein localization" EXACT [] synonym: "regulation of protein localisation" EXACT [GOC:mah] -is_a: GO:0032879 ! regulation of localization +is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008104 ! protein localization relationship: regulates GO:0008104 ! protein localization @@ -59711,7 +91080,7 @@ comment: Note that although at some level almost all cellular components can be subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon -subset: goslim_generic +subset: goslim_mouse subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] @@ -59851,11 +91220,15 @@ name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] subset: goslim_pombe +subset: prokaryote_subset synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:26932 ! tetrapyrrole +relationship: has_primary_input_or_output CHEBI:26932 ! tetrapyrrole [Term] id: GO:0033014 @@ -59872,6 +91245,27 @@ is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:26932 ! tetrapyrrole +relationship: has_primary_output CHEBI:26932 ! tetrapyrrole + +[Term] +id: GO:0033015 +name: tetrapyrrole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] +synonym: "tetrapyrrole breakdown" EXACT [] +synonym: "tetrapyrrole catabolism" EXACT [] +synonym: "tetrapyrrole degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:26932 ! tetrapyrrole +relationship: has_primary_input CHEBI:26932 ! tetrapyrrole [Term] id: GO:0033018 @@ -60006,8 +91400,8 @@ def: "Any process in which a polysaccharide is transported to, or maintained in, synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization intersection_of: GO:0033036 ! macromolecule localization -intersection_of: transports_or_maintains_localization_of CHEBI:18154 ! polysaccharide -relationship: transports_or_maintains_localization_of CHEBI:18154 ! polysaccharide +intersection_of: has_primary_input CHEBI:18154 ! polysaccharide +relationship: has_primary_input CHEBI:18154 ! polysaccharide [Term] id: GO:0033043 @@ -60185,7 +91579,7 @@ is_a: GO:0051223 ! regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006886 ! intracellular protein transport relationship: regulates GO:0006886 ! intracellular protein transport -relationship: regulates GO:0034613 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/geneontology/go-ontology/issues/13926"} ! cellular protein localization +relationship: regulates GO:0034613 ! cellular protein localization [Term] id: GO:0033162 @@ -60215,9 +91609,9 @@ is_a: GO:0006879 ! cellular iron ion homeostasis is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0098657 ! import into cell intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24875 ! iron cation intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure intersection_of: has_target_start_location GO:0005576 ! extracellular region -intersection_of: transports_or_maintains_localization_of CHEBI:24875 ! iron cation created_by: mah creation_date: 2009-05-01T04:19:14Z @@ -60270,6 +91664,50 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044106 ! cellular amine metabolic process relationship: positively_regulates GO:0044106 ! cellular amine metabolic process +[Term] +id: GO:0033241 +name: regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "regulation of amine breakdown" EXACT [] +synonym: "regulation of amine catabolism" EXACT [] +synonym: "regulation of amine degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0009310 ! amine catabolic process +relationship: regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033242 +name: negative regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "negative regulation of amine breakdown" EXACT [] +synonym: "negative regulation of amine catabolism" EXACT [] +synonym: "negative regulation of amine degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0033241 ! regulation of cellular amine catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0009310 ! amine catabolic process +relationship: negatively_regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033243 +name: positive regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "positive regulation of amine breakdown" EXACT [] +synonym: "positive regulation of amine catabolism" EXACT [] +synonym: "positive regulation of amine degradation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0033241 ! regulation of cellular amine catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0009310 ! amine catabolic process +relationship: positively_regulates GO:0009310 ! amine catabolic process + [Term] id: GO:0033268 name: node of Ranvier @@ -60508,6 +91946,23 @@ namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah] is_a: GO:0033500 ! carbohydrate homeostasis +[Term] +id: GO:0033526 +name: tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [GOC:mah, MetaCyc:PWY-5188] +synonym: "tetrapyrrole anabolism from glutamate" EXACT [] +synonym: "tetrapyrrole biosynthesis from glutamate" EXACT [] +synonym: "tetrapyrrole formation from glutamate" EXACT [] +synonym: "tetrapyrrole synthesis from glutamate" EXACT [] +xref: MetaCyc:PWY-5188 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_input CHEBI:14321 ! glutamate(1-) +intersection_of: has_primary_output CHEBI:26932 ! tetrapyrrole +relationship: has_primary_input CHEBI:14321 ! glutamate(1-) + [Term] id: GO:0033554 name: cellular response to stress @@ -60537,6 +91992,17 @@ synonym: "skin barrier function" RELATED [] is_a: GO:0050891 ! multicellular organismal water homeostasis property_value: RO:0002161 NCBITaxon:6656 +[Term] +id: GO:0033569 +name: lactoferrin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_input PR:000009978 ! lactotransferrin +relationship: has_input PR:000009978 ! lactotransferrin +relationship: part_of GO:0033571 ! lactoferrin transport + [Term] id: GO:0033571 name: lactoferrin transport @@ -60545,40 +92011,25 @@ def: "The directed movement of lactoferrin into, out of or within a cell, or bet is_a: GO:0006826 ! iron ion transport is_a: GO:0015031 ! protein transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of PR:000009978 ! lactotransferrin -relationship: transports_or_maintains_localization_of PR:000009978 ! lactotransferrin +intersection_of: has_primary_input PR:000009978 ! lactotransferrin +relationship: has_primary_input PR:000009978 ! lactotransferrin [Term] id: GO:0033576 name: protein glycosylation in cytosol -namespace: biological_process -def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244] -synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf] +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [] +synonym: "protein amino acid glycosylation in cytosol" EXACT [] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005829 ! cytosol relationship: occurs_in GO:0005829 ! cytosol -[Term] -id: GO:0033577 -name: protein glycosylation in endoplasmic reticulum -namespace: biological_process -def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244] -synonym: "core glycosylation" RELATED [PMID:6345657] -synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf] -synonym: "protein amino acid glycosylation in ER" EXACT [] -is_a: GO:0006486 ! protein glycosylation -intersection_of: GO:0006486 ! protein glycosylation -intersection_of: occurs_in GO:0005783 ! endoplasmic reticulum -relationship: occurs_in GO:0005783 ! endoplasmic reticulum - [Term] id: GO:0033578 name: protein glycosylation in Golgi -namespace: biological_process -def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244] -synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf] -synonym: "terminal glycosylation" NARROW [PMID:6345657] +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [] +synonym: "protein amino acid glycosylation in Golgi" EXACT [] +synonym: "terminal glycosylation" NARROW [] is_a: GO:0006486 ! protein glycosylation intersection_of: GO:0006486 ! protein glycosylation intersection_of: occurs_in GO:0005794 ! Golgi apparatus @@ -60646,8 +92097,8 @@ synonym: "down-regulation of dopamine secretion" EXACT [] synonym: "downregulation of dopamine secretion" EXACT [] synonym: "inhibition of dopamine secretion" NARROW [] is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion is_a: GO:0043271 ! negative regulation of ion transport -is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0014046 ! dopamine secretion relationship: negatively_regulates GO:0014046 ! dopamine secretion @@ -60663,8 +92114,8 @@ synonym: "up regulation of dopamine secretion" EXACT [] synonym: "up-regulation of dopamine secretion" EXACT [] synonym: "upregulation of dopamine secretion" EXACT [] is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion is_a: GO:0043270 ! positive regulation of ion transport -is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0014046 ! dopamine secretion relationship: positively_regulates GO:0014046 ! dopamine secretion @@ -60778,21 +92229,20 @@ intersection_of: positively_regulates GO:0032275 ! luteinizing hormone secretion relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion [Term] -id: GO:0033696 -name: heterochromatin boundary formation +id: GO:0033692 +name: cellular polysaccharide biosynthetic process namespace: biological_process -alt_id: GO:0031454 -def: "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome." [GOC:mah] -synonym: "maintenance of heterochromatin boundaries" RELATED [] -synonym: "negative regulation of extent of heterochromatin assembly" RELATED [] -synonym: "negative regulation of extent of heterochromatin formation" RELATED [] -synonym: "negative regulation of heterochromatin spreading" RELATED [] -synonym: "regulation of extent of heterochromatin assembly" RELATED [] -synonym: "regulation of extent of heterochromatin formation" EXACT [] -synonym: "regulation of heterochromatin spreading" RELATED [] -is_a: GO:0070828 ! heterochromatin organization -relationship: part_of GO:0031507 ! heterochromatin assembly -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22028 xsd:anyURI +def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [GOC:go_curators] +synonym: "cellular glycan biosynthesis" EXACT [] +synonym: "cellular glycan biosynthetic process" EXACT [] +synonym: "cellular polysaccharide anabolism" EXACT [] +synonym: "cellular polysaccharide biosynthesis" EXACT [] +synonym: "cellular polysaccharide formation" EXACT [] +synonym: "cellular polysaccharide synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0033750 @@ -60805,8 +92255,8 @@ synonym: "establishment of ribosome localization" RELATED [] synonym: "ribosome localisation" RELATED [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005840 ! ribosome -relationship: transports_or_maintains_localization_of GO:0005840 ! ribosome +intersection_of: has_primary_input GO:0005840 ! ribosome +relationship: has_primary_input GO:0005840 ! ribosome [Term] id: GO:0033762 @@ -60957,6 +92407,25 @@ synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:16646 ! carbohydrate +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0034220 +name: ion transmembrane transport +namespace: biological_process +alt_id: GO:0099131 +def: "A process in which an ion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] +synonym: "ion membrane transport" EXACT [] +synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006811 ! ion transport +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24870 ! ion +intersection_of: results_in_transport_across GO:0016020 ! membrane [Term] id: GO:0034242 @@ -61008,6 +92477,17 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043603 ! cellular amide metabolic process relationship: positively_regulates GO:0043603 ! cellular amide metabolic process +[Term] +id: GO:0034284 +name: response to monosaccharide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] +synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] +is_a: GO:0009743 ! response to carbohydrate +intersection_of: GO:0050896 ! response to stimulus +intersection_of: has_input CHEBI:35381 ! monosaccharide +relationship: has_input CHEBI:35381 ! monosaccharide + [Term] id: GO:0034308 name: primary alcohol metabolic process @@ -61218,8 +92698,34 @@ def: "The directed movement of a glycoprotein, a protein that contains covalentl is_a: GO:0015031 ! protein transport is_a: GO:1901264 ! carbohydrate derivative transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:17089 ! glycoprotein -relationship: transports_or_maintains_localization_of CHEBI:17089 ! glycoprotein +intersection_of: has_primary_input CHEBI:17089 ! glycoprotein +relationship: has_primary_input CHEBI:17089 ! glycoprotein + +[Term] +id: GO:0034486 +name: vacuolar transmembrane transport +namespace: biological_process +def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "vacuolar membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: results_in_transport_across GO:0016020 ! membrane +intersection_of: results_in_transport_to_from_or_in GO:0005773 ! vacuole +relationship: results_in_transport_to_from_or_in GO:0005773 ! vacuole + +[Term] +id: GO:0034487 +name: vacuolar amino acid transmembrane transport +namespace: biological_process +def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "vacuolar amino acid membrane transport" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 ! amino acid +intersection_of: results_in_transport_across GO:0005774 ! vacuolar membrane +relationship: results_in_transport_across GO:0005774 ! vacuolar membrane [Term] id: GO:0034502 @@ -61261,13 +92767,19 @@ relationship: part_of GO:0042476 ! odontogenesis [Term] id: GO:0034613 name: cellular protein localization -namespace: biological_process -alt_id: GO:0016249 -def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] -synonym: "cellular protein localisation" EXACT [GOC:mah] -synonym: "channel localizer activity" NARROW [GOC:mah] +def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [] +synonym: "cellular protein localisation" EXACT [] +synonym: "channel localizer activity" NARROW [] is_a: GO:0008104 ! protein localization -is_a: GO:0070727 ! cellular macromolecule localization + +[Term] +id: GO:0034637 +name: cellular carbohydrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0034641 @@ -61312,6 +92824,25 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity relationship: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity +[Term] +id: GO:0034655 +name: nucleobase-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] +subset: goslim_chembl +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity +relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity + [Term] id: GO:0034754 name: cellular hormone metabolic process @@ -61320,6 +92851,36 @@ def: "The chemical reactions and pathways involving any hormone, naturally occur is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process +[Term] +id: GO:0034755 +name: iron ion transmembrane transport +namespace: biological_process +alt_id: GO:0000040 +alt_id: GO:0006827 +alt_id: GO:0061839 +alt_id: GO:1903874 +def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ferrous ion transmembrane transport" NARROW [] +synonym: "ferrous iron transmembrane transport" NARROW [] +synonym: "high affinity ferrous ion transmembrane transport" NARROW [] +synonym: "high affinity iron ion transport" NARROW [] +synonym: "high-affinity ferrous ion transmembrane transport" NARROW [] +synonym: "high-affinity iron ion transmembrane transport" NARROW [] +synonym: "high-affinity iron ion transport" NARROW [] +synonym: "iron ion membrane transport" EXACT [] +synonym: "iron(2+) transmembrane transport" NARROW [] +synonym: "low affinity iron ion transport" NARROW [] +synonym: "low-affinity iron ion transmembrane transport" NARROW [] +synonym: "low-affinity iron ion transport" NARROW [] +synonym: "transmembrane iron transport" EXACT [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport +intersection_of: GO:0006826 ! iron ion transport +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: vw +creation_date: 2015-02-06T11:29:22Z + [Term] id: GO:0034756 name: regulation of iron ion transport @@ -61370,6 +92931,60 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006826 ! iron ion transport relationship: positively_regulates GO:0006826 ! iron ion transport +[Term] +id: GO:0034759 +name: regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "regulation of iron ion membrane transport" EXACT [] +synonym: "regulation of transmembrane Fe transport" EXACT [] +synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0034755 ! iron ion transmembrane transport +relationship: regulates GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0034760 +name: negative regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of transmembrane iron ion transport" EXACT [] +synonym: "down-regulation of transmembrane iron ion transport" EXACT [] +synonym: "downregulation of transmembrane iron ion transport" EXACT [] +synonym: "inhibition of transmembrane iron ion transport" NARROW [] +synonym: "negative regulation of iron ion membrane transport" EXACT [] +synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034757 ! negative regulation of iron ion transport +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0034755 ! iron ion transmembrane transport +relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0034761 +name: positive regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of transmembrane iron ion transport" NARROW [] +synonym: "positive regulation of iron ion membrane transport" EXACT [] +synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of transmembrane iron transport" EXACT [] +synonym: "stimulation of transmembrane iron ion transport" NARROW [] +synonym: "up regulation of transmembrane iron ion transport" EXACT [] +synonym: "up-regulation of transmembrane iron ion transport" EXACT [] +synonym: "upregulation of transmembrane iron ion transport" EXACT [] +is_a: GO:0034758 ! positive regulation of iron ion transport +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0034755 ! iron ion transmembrane transport +relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport + [Term] id: GO:0034762 name: regulation of transmembrane transport @@ -61417,6 +93032,56 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0055085 ! transmembrane transport relationship: positively_regulates GO:0055085 ! transmembrane transport +[Term] +id: GO:0034765 +name: regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "regulation of ion membrane transport" EXACT [] +synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0043269 ! regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0034220 ! ion transmembrane transport +relationship: regulates GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0034766 +name: negative regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane ion transport" EXACT [] +synonym: "down-regulation of transmembrane ion transport" EXACT [] +synonym: "downregulation of transmembrane ion transport" EXACT [] +synonym: "inhibition of transmembrane ion transport" NARROW [] +synonym: "negative regulation of ion membrane transport" EXACT [] +synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0043271 ! negative regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0034220 ! ion transmembrane transport +relationship: negatively_regulates GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0034767 +name: positive regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane ion transport" NARROW [] +synonym: "positive regulation of ion membrane transport" EXACT [] +synonym: "positive regulation of transmembrane ion transport" EXACT [] +synonym: "stimulation of transmembrane ion transport" NARROW [] +synonym: "up regulation of transmembrane ion transport" EXACT [] +synonym: "up-regulation of transmembrane ion transport" EXACT [] +synonym: "upregulation of transmembrane ion transport" EXACT [] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0043270 ! positive regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0034220 ! ion transmembrane transport +relationship: positively_regulates GO:0034220 ! ion transmembrane transport + [Term] id: GO:0034769 name: basement membrane disassembly @@ -61812,6 +93477,13 @@ def: "The process in which a relatively unspecialized cell acquires specialized is_a: GO:0009913 ! epidermal cell differentiation is_a: GO:0030182 ! neuron differentiation +[Term] +id: GO:0035369 +name: pre-B cell receptor complex +def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [] +synonym: "pre-BCR" EXACT [] +is_a: GO:0098796 ! membrane protein complex + [Term] id: GO:0035372 name: protein localization to microtubule @@ -61838,6 +93510,36 @@ relationship: has_target_end_location GO:0045202 ! synapse created_by: bf creation_date: 2010-03-29T10:58:53Z +[Term] +id: GO:0035433 +name: acetate transmembrane transport +namespace: biological_process +def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "acetate membrane transport" EXACT [] +is_a: GO:0006846 ! acetate transport +is_a: GO:0098656 ! anion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:30089 ! acetate +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: bf +creation_date: 2010-04-08T10:59:01Z + +[Term] +id: GO:0035435 +name: phosphate ion transmembrane transport +namespace: biological_process +def: "The process in which a phosphate is transported across a membrane." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "phosphate ion membrane transport" EXACT [] +is_a: GO:0006817 ! phosphate ion transport +is_a: GO:0098661 ! inorganic anion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:35780 ! phosphate ion +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: bf +creation_date: 2010-04-08T11:24:06Z + [Term] id: GO:0035441 name: cell migration involved in vasculogenesis @@ -61961,6 +93663,33 @@ intersection_of: has_target_end_location GO:0005576 ! extracellular region created_by: bf creation_date: 2010-11-09T10:25:08Z +[Term] +id: GO:0035622 +name: intrahepatic bile duct development +namespace: biological_process +def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] +synonym: "IHBD development" EXACT [PMID:20614624] +synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] +is_a: GO:0061009 ! common bile duct development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003704 ! intrahepatic bile duct +relationship: part_of GO:0001889 ! liver development +relationship: results_in_development_of UBERON:0003704 ! intrahepatic bile duct +created_by: bf +creation_date: 2010-12-08T04:10:50Z + +[Term] +id: GO:0035628 +name: cystic duct development +namespace: biological_process +def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct." [PMID:20614624] +is_a: GO:0061009 ! common bile duct development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001152 ! cystic duct +relationship: results_in_development_of UBERON:0001152 ! cystic duct +created_by: bf +creation_date: 2010-12-10T01:24:28Z + [Term] id: GO:0035630 name: bone mineralization involved in bone maturation @@ -61999,6 +93728,20 @@ is_a: GO:0007610 ! behavior created_by: bf creation_date: 2011-01-19T10:35:45Z +[Term] +id: GO:0035645 +name: enteric smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] +synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] +is_a: GO:0051145 ! smooth muscle cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0002504 ! enteric smooth muscle cell +relationship: part_of GO:0048565 ! digestive tract development +relationship: results_in_acquisition_of_features_of CL:0002504 ! enteric smooth muscle cell +created_by: bf +creation_date: 2011-01-21T02:58:58Z + [Term] id: GO:0035701 name: hematopoietic stem cell migration @@ -62034,6 +93777,20 @@ is_a: GO:0046631 ! alpha-beta T cell activation created_by: bf creation_date: 2011-03-02T03:04:11Z +[Term] +id: GO:0035725 +name: sodium ion transmembrane transport +namespace: biological_process +def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "sodium ion membrane transport" EXACT [] +is_a: GO:0006814 ! sodium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport +intersection_of: GO:0055085 ! transmembrane transport +intersection_of: has_primary_input CHEBI:29101 ! sodium(1+) +created_by: bf +creation_date: 2011-03-10T02:52:36Z + [Term] id: GO:0035735 name: intraciliary transport involved in cilium assembly @@ -62074,6 +93831,34 @@ intersection_of: results_in_movement_of CL:0000115 ! endothelial cell created_by: bf creation_date: 2011-03-31T04:31:37Z +[Term] +id: GO:0035773 +name: insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] +synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] +is_a: GO:0030073 ! insulin secretion +is_a: GO:0051649 ! establishment of localization in cell +intersection_of: GO:0030073 ! insulin secretion +intersection_of: part_of GO:0071333 ! cellular response to glucose stimulus +relationship: part_of GO:0071333 ! cellular response to glucose stimulus +created_by: bf +creation_date: 2011-04-01T01:14:40Z + +[Term] +id: GO:0035774 +name: positive regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] +synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] +is_a: GO:0032024 ! positive regulation of insulin secretion +is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +created_by: bf +creation_date: 2011-04-01T01:49:09Z + [Term] id: GO:0035779 name: angioblast cell differentiation @@ -62113,6 +93898,32 @@ relationship: part_of GO:0001656 ! metanephros development created_by: bf creation_date: 2011-04-06T10:42:21Z +[Term] +id: GO:0035805 +name: egg coat +namespace: cellular_component +def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] +synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408] +synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408] +is_a: CARO:0000000 ! anatomical entity +is_a: GO:0031012 ! extracellular matrix +intersection_of: GO:0031012 ! extracellular matrix +intersection_of: part_of CL:0000025 ! egg cell +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +relationship: part_of CL:0000025 ! egg cell +created_by: bf +creation_date: 2011-04-19T02:07:23Z + +[Term] +id: GO:0035809 +name: regulation of urine volume +def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [] +synonym: "regulation of urinary volume" EXACT [] +synonym: "regulation of urine flow" EXACT [] +is_a: GO:0003014 ! renal system process +is_a: GO:0050878 ! regulation of body fluid levels + [Term] id: GO:0035834 name: indole alkaloid metabolic process @@ -62150,11 +93961,59 @@ namespace: biological_process def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] synonym: "cloacal development" EXACT [GOC:bf] is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0000162 ! cloaca relationship: part_of GO:0001655 ! urogenital system development relationship: part_of GO:0048546 ! digestive tract morphogenesis +relationship: results_in_development_of UBERON:0000162 ! cloaca created_by: bf creation_date: 2011-05-06T01:54:35Z +[Term] +id: GO:0035846 +name: oviduct epithelium development +namespace: biological_process +def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube epithelium development" NARROW [GOC:yaf] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060429 ! epithelium development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0004804 ! oviduct epithelium +relationship: part_of GO:0060066 ! oviduct development +relationship: results_in_development_of UBERON:0004804 ! oviduct epithelium +created_by: bf +creation_date: 2011-05-10T10:53:05Z + +[Term] +id: GO:0035847 +name: uterine epithelium development +namespace: biological_process +def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf] +synonym: "uterus epithelial development" EXACT [GOC:yaf] +is_a: GO:0035846 ! oviduct epithelium development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0006955 ! uterine epithelium +relationship: part_of GO:0060065 ! uterus development +relationship: results_in_development_of UBERON:0006955 ! uterine epithelium +created_by: bf +creation_date: 2011-05-10T10:57:45Z + +[Term] +id: GO:0035848 +name: oviduct morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0035239 ! tube morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0000993 ! oviduct +relationship: part_of GO:0060066 ! oviduct development +relationship: results_in_morphogenesis_of UBERON:0000993 ! oviduct +created_by: bf +creation_date: 2011-05-10T11:01:20Z + [Term] id: GO:0035850 name: epithelial cell differentiation involved in kidney development @@ -62235,6 +94094,15 @@ relationship: results_in_acquisition_of_features_of CL:0002539 ! aortic smooth m created_by: bf creation_date: 2011-06-08T11:34:26Z +[Term] +id: GO:0035898 +name: parathyroid hormone secretion +def: "The regulated release of parathyroid hormone into the circulatory system." [] +synonym: "parathormone secretion" EXACT [] +synonym: "parathyrin secretion" EXACT [] +synonym: "PTH secretion" EXACT [] +is_a: GO:0060986 ! endocrine hormone secretion + [Term] id: GO:0035904 name: aorta development @@ -62247,6 +94115,19 @@ relationship: results_in_development_of UBERON:0000947 ! aorta created_by: bf creation_date: 2011-06-24T11:00:07Z +[Term] +id: GO:0035905 +name: ascending aorta development +namespace: biological_process +def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] +is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001496 ! ascending aorta +relationship: part_of GO:0035904 ! aorta development +relationship: results_in_development_of UBERON:0001496 ! ascending aorta +created_by: bf +creation_date: 2011-06-24T11:02:01Z + [Term] id: GO:0035906 name: descending aorta development @@ -62285,6 +94166,20 @@ relationship: results_in_morphogenesis_of UBERON:0000947 ! aorta created_by: bf creation_date: 2011-06-24T11:11:11Z +[Term] +id: GO:0035910 +name: ascending aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] +is_a: GO:0009653 ! anatomical structure morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0001496 ! ascending aorta +relationship: part_of GO:0035905 ! ascending aorta development +relationship: part_of GO:0035909 ! aorta morphogenesis +relationship: results_in_morphogenesis_of UBERON:0001496 ! ascending aorta +created_by: bf +creation_date: 2011-06-24T11:14:52Z + [Term] id: GO:0035911 name: descending aorta morphogenesis @@ -62333,8 +94228,8 @@ def: "The regulated release of any steroid that acts as a hormone into the circu is_a: GO:0060986 ! endocrine hormone secretion is_a: GO:0140353 ! lipid export from cell intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:26764 ! steroid hormone -relationship: transports_or_maintains_localization_of CHEBI:26764 ! steroid hormone +intersection_of: has_primary_input CHEBI:26764 ! steroid hormone +relationship: has_primary_input CHEBI:26764 ! steroid hormone created_by: bf creation_date: 2011-07-20T01:01:00Z @@ -62348,6 +94243,19 @@ is_a: GO:0035929 ! steroid hormone secretion created_by: bf creation_date: 2011-07-20T01:03:22Z +[Term] +id: GO:0035931 +name: mineralocorticoid secretion +def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [] +is_a: GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:0035932 +name: aldosterone secretion +def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0035931 ! mineralocorticoid secretion + [Term] id: GO:0035933 name: glucocorticoid secretion @@ -62376,6 +94284,14 @@ is_a: GO:0035929 ! steroid hormone secretion created_by: bf creation_date: 2011-07-20T01:11:31Z +[Term] +id: GO:0035936 +name: testosterone secretion +def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + [Term] id: GO:0035981 name: tongue muscle cell differentiation @@ -62587,6 +94503,33 @@ is_a: GO:0005858 ! axonemal dynein complex created_by: bf creation_date: 2012-03-21T01:25:03Z +[Term] +id: GO:0036160 +name: melanocyte-stimulating hormone secretion +def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [] +synonym: "MSH secretion" EXACT [] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036161 +name: calcitonin secretion +def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036179 +name: osteoclast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg] +synonym: "chondroclast maturation" RELATED [CL:0000092] +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000092 ! osteoclast +relationship: part_of GO:0036035 ! osteoclast development +relationship: results_in_maturation_of CL:0000092 ! osteoclast +created_by: bf +creation_date: 2012-03-29T02:04:00Z + [Term] id: GO:0036194 name: muscle cell projection @@ -62620,11 +94563,20 @@ creation_date: 2012-04-20T10:21:51Z id: GO:0036211 name: protein modification process namespace: biological_process +alt_id: GO:0006464 def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] +subset: goslim_candida +subset: goslim_chembl subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: prokaryote_subset +synonym: "cellular protein modification process" EXACT [] +synonym: "process resulting in protein modification" EXACT [] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI created_by: bf creation_date: 2012-04-26T01:47:12Z @@ -62640,6 +94592,13 @@ relationship: has_input CL:0000094 ! granulocyte created_by: bf creation_date: 2012-05-11T10:57:48Z +[Term] +id: GO:0036293 +name: response to decreased oxygen levels +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [] +synonym: "response to lowered oxygen levels" EXACT [] +is_a: GO:0070482 ! response to oxygen levels + [Term] id: GO:0036303 name: lymph vessel morphogenesis @@ -62650,6 +94609,18 @@ relationship: part_of GO:0001945 ! lymph vessel development created_by: bf creation_date: 2012-08-08T10:08:47Z +[Term] +id: GO:0036333 +name: hepatocyte homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874] +is_a: GO:0048872 ! homeostasis of number of cells +intersection_of: GO:0048872 ! homeostasis of number of cells +intersection_of: acts_on_population_of CL:0000182 ! hepatocyte +relationship: acts_on_population_of CL:0000182 ! hepatocyte +created_by: bf +creation_date: 2012-09-05T10:17:07Z + [Term] id: GO:0036334 name: epidermal stem cell homeostasis @@ -62683,18 +94654,6 @@ is_a: GO:0009653 ! anatomical structure morphogenesis created_by: bf creation_date: 2012-09-11T13:54:49Z -[Term] -id: GO:0036385 -name: nucleoid DNA packaging -namespace: biological_process -def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm] -is_a: GO:0006323 ! DNA packaging -intersection_of: GO:0006323 ! DNA packaging -intersection_of: occurs_in GO:0009295 ! nucleoid -relationship: occurs_in GO:0009295 ! nucleoid -created_by: bf -creation_date: 2013-05-30T10:36:05Z - [Term] id: GO:0036446 name: myofibroblast differentiation @@ -62771,7 +94730,7 @@ creation_date: 2011-08-01T02:45:27Z id: GO:0038169 name: somatostatin receptor signaling pathway namespace: biological_process -def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369] +def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:jc, PMID:18006219, PMID:8769369] comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. synonym: "SST receptor signaling pathway" EXACT [GOC:bf] synonym: "SSTR signaling pathway" RELATED [GOC:bf] @@ -62783,7 +94742,7 @@ creation_date: 2012-06-12T10:30:01Z id: GO:0038170 name: somatostatin signaling pathway namespace: biological_process -def: "The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin] +def: "A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin] synonym: "somatostatin signalling pathway" EXACT [GOC:bf] synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf] synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf] @@ -62978,10 +94937,11 @@ relationship: regulates GO:0140013 ! meiotic nuclear division [Term] id: GO:0040029 -name: regulation of gene expression, epigenetic +name: epigenetic regulation of gene expression namespace: biological_process -def: "A process that modulates the frequency, rate or extent of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] +def: "A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] subset: goslim_plant +synonym: "regulation of gene expression, epigenetic" EXACT [] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0006325 ! chromatin organization property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22201 xsd:anyURI @@ -62996,6 +94956,12 @@ synonym: "heterochronic regulation of development" EXACT [] synonym: "temporal regulation of development" EXACT [] is_a: GO:0050793 ! regulation of developmental process +[Term] +id: GO:0042044 +name: fluid transport +def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [] +is_a: GO:0006810 ! transport + [Term] id: GO:0042053 name: regulation of dopamine metabolic process @@ -63066,9 +95032,9 @@ xref: Wikipedia:Intraflagellar_transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0032991 ! protein-containing complex intersection_of: occurs_in GO:0005929 ! cilium intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:0032991 ! protein-containing complex relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: occurs_in GO:0005929 ! cilium relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota @@ -63157,6 +95123,17 @@ synonym: "B-lymphocyte proliferation" EXACT [] is_a: GO:0042113 ! B cell activation is_a: GO:0046651 ! lymphocyte proliferation +[Term] +id: GO:0042101 +name: T cell receptor complex +def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [] +synonym: "T lymphocyte receptor complex" EXACT [] +synonym: "T-cell receptor complex" EXACT [] +synonym: "T-lymphocyte receptor complex" EXACT [] +synonym: "TCR" RELATED [] +synonym: "TCR complex" EXACT [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + [Term] id: GO:0042102 name: positive regulation of T cell proliferation @@ -63215,6 +95192,16 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0050798 ! activated T cell proliferation relationship: positively_regulates GO:0050798 ! activated T cell proliferation +[Term] +id: GO:0042105 +name: alpha-beta T cell receptor complex +def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [] +synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta T-cell receptor complex" EXACT [] +synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta TCR complex" EXACT [] +is_a: GO:0042101 ! T cell receptor complex + [Term] id: GO:0042110 name: T cell activation @@ -63335,6 +95322,18 @@ is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0044237 ! cellular metabolic process property_value: RO:0002161 NCBITaxon:4895 +[Term] +id: GO:0042135 +name: neurotransmitter catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] +subset: goslim_synapse +synonym: "neurotransmitter breakdown" EXACT [] +synonym: "neurotransmitter catabolism" EXACT [] +synonym: "neurotransmitter degradation" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0044248 ! cellular catabolic process + [Term] id: GO:0042136 name: neurotransmitter biosynthetic process @@ -63405,6 +95404,76 @@ synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane relationship: part_of GO:0012505 ! endomembrane system +[Term] +id: GO:0042176 +name: regulation of protein catabolic process +namespace: biological_process +alt_id: GO:1903362 +alt_id: GO:2000598 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] +synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolic process" EXACT [] +synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] +synonym: "regulation of cyclin catabolic process" NARROW [] +synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] +synonym: "regulation of cyclin degradation" NARROW [GOC:obol] +synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] +synonym: "regulation of protein breakdown" EXACT [] +synonym: "regulation of protein catabolism" EXACT [] +synonym: "regulation of protein degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0030163 ! protein catabolic process +relationship: regulates GO:0030163 ! protein catabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI +created_by: kmv +creation_date: 2014-08-21T15:05:45Z + +[Term] +id: GO:0042177 +name: negative regulation of protein catabolic process +namespace: biological_process +alt_id: GO:1903363 +alt_id: GO:2000599 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] +synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein catabolic process" EXACT [] +synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein catabolic process" EXACT [] +synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein catabolic process" EXACT [] +synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein catabolic process" NARROW [] +synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolic process" EXACT [] +synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein breakdown" EXACT [] +synonym: "negative regulation of protein catabolism" EXACT [] +synonym: "negative regulation of protein degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0030163 ! protein catabolic process +relationship: negatively_regulates GO:0030163 ! protein catabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI + [Term] id: GO:0042180 name: cellular ketone metabolic process @@ -63448,6 +95517,9 @@ is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:17087 ! ketone +relationship: has_primary_input CHEBI:17087 ! ketone [Term] id: GO:0042221 @@ -63483,13 +95555,13 @@ name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe +subset: prokaryote_subset synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0022613 ! ribonucleoprotein complex biogenesis @@ -63704,6 +95776,7 @@ name: regulation of membrane potential namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] is_a: GO:0065008 ! regulation of biological quality +relationship: has_part GO:0034220 ! ion transmembrane transport [Term] id: GO:0042401 @@ -63717,6 +95790,25 @@ synonym: "biogenic amine synthesis" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009309 ! amine biosynthetic process +[Term] +id: GO:0042402 +name: cellular biogenic amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] +synonym: "biogenic amine breakdown" EXACT [] +synonym: "biogenic amine catabolism" EXACT [] +synonym: "biogenic amine degradation" EXACT [] +is_a: GO:0009310 ! amine catabolic process + +[Term] +id: GO:0042403 +name: thyroid hormone metabolic process +def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [] +synonym: "thyroid hormone metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042445 ! hormone metabolic process + [Term] id: GO:0042415 name: norepinephrine metabolic process @@ -63727,10 +95819,11 @@ synonym: "levarterenol metabolism" EXACT [] synonym: "noradrenaline metabolic process" EXACT [] synonym: "noradrenaline metabolism" EXACT [] synonym: "norepinephrine metabolism" EXACT [] -is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:33569 ! noradrenaline -relationship: has_primary_input_or_output CHEBI:33569 ! noradrenaline +intersection_of: has_primary_input_or_output CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_primary_input_or_output CHEBI:72587 ! (R)-noradrenaline(1+) [Term] id: GO:0042416 @@ -63758,6 +95851,20 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:59905 ! dopaminium(1+) relationship: has_primary_input_or_output CHEBI:59905 ! dopaminium(1+) +[Term] +id: GO:0042420 +name: dopamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] +synonym: "dopamine breakdown" EXACT [] +synonym: "dopamine catabolism" EXACT [] +synonym: "dopamine degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0042417 ! dopamine metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:59905 ! dopaminium(1+) +relationship: has_primary_input CHEBI:59905 ! dopaminium(1+) + [Term] id: GO:0042421 name: norepinephrine biosynthetic process @@ -63772,10 +95879,29 @@ synonym: "norepinephrine biosynthesis" EXACT [] synonym: "norepinephrine formation" EXACT [] synonym: "norepinephrine synthesis" EXACT [] is_a: GO:0042415 ! norepinephrine metabolic process -is_a: GO:0042423 ! catecholamine biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:33569 ! noradrenaline -relationship: has_primary_output CHEBI:33569 ! noradrenaline +intersection_of: has_primary_output CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_primary_output CHEBI:72587 ! (R)-noradrenaline(1+) + +[Term] +id: GO:0042422 +name: norepinephrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] +synonym: "levarterenol catabolic process" EXACT [] +synonym: "levarterenol catabolism" EXACT [] +synonym: "noradrenaline catabolic process" EXACT [] +synonym: "noradrenaline catabolism" EXACT [] +synonym: "norepinephrine breakdown" EXACT [] +synonym: "norepinephrine catabolism" EXACT [] +synonym: "norepinephrine degradation" EXACT [] +xref: Wikipedia:Norepinephrine#Degradation +is_a: GO:0042415 ! norepinephrine metabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) [Term] id: GO:0042423 @@ -63794,6 +95920,21 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33567 ! catecholamine relationship: has_primary_output CHEBI:33567 ! catecholamine +[Term] +id: GO:0042424 +name: catecholamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] +synonym: "catecholamine breakdown" EXACT [] +synonym: "catecholamine catabolism" EXACT [] +synonym: "catecholamine degradation" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33567 ! catecholamine +relationship: has_primary_input CHEBI:33567 ! catecholamine + [Term] id: GO:0042427 name: serotonin biosynthetic process @@ -63824,6 +95965,20 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:350546 ! serotonin(1+) relationship: has_primary_input_or_output CHEBI:350546 ! serotonin(1+) +[Term] +id: GO:0042429 +name: serotonin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] +synonym: "serotonin breakdown" EXACT [] +synonym: "serotonin catabolism" EXACT [] +synonym: "serotonin degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0042428 ! serotonin metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+) +relationship: has_primary_input CHEBI:350546 ! serotonin(1+) + [Term] id: GO:0042430 name: indole-containing compound metabolic process @@ -63867,6 +96022,26 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:24828 ! indoles relationship: has_primary_output CHEBI:24828 ! indoles +[Term] +id: GO:0042436 +name: indole-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] +synonym: "indole derivative catabolic process" EXACT [] +synonym: "indole derivative catabolism" EXACT [] +synonym: "indole-containing compound breakdown" EXACT [] +synonym: "indole-containing compound catabolism" EXACT [] +synonym: "indole-containing compound degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:24828 ! indoles +relationship: has_primary_input CHEBI:24828 ! indoles + [Term] id: GO:0042438 name: melanin biosynthetic process @@ -63902,6 +96077,17 @@ is_a: GO:0008152 ! metabolic process is_a: GO:0010817 ! regulation of hormone levels property_value: RO:0002161 NCBITaxon:4895 +[Term] +id: GO:0042446 +name: hormone biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [] +synonym: "hormone anabolism" EXACT [] +synonym: "hormone biosynthesis" EXACT [] +synonym: "hormone formation" EXACT [] +synonym: "hormone synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0042445 ! hormone metabolic process + [Term] id: GO:0042461 name: photoreceptor cell development @@ -64171,7 +96357,10 @@ name: neuron maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000540 ! neuron relationship: part_of GO:0048666 ! neuron development +relationship: results_in_maturation_of CL:0000540 ! neuron [Term] id: GO:0042552 @@ -64191,6 +96380,14 @@ subset: goslim_chembl subset: goslim_pir is_a: GO:0005488 ! binding +[Term] +id: GO:0042571 +name: immunoglobulin complex, circulating +def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [] +synonym: "antibody" EXACT [] +is_a: GO:0019814 ! immunoglobulin complex +relationship: part_of GO:0005615 ! extracellular space + [Term] id: GO:0042572 name: retinol metabolic process @@ -64235,6 +96432,24 @@ is_a: GO:0005766 ! primary lysosome is_a: GO:0030141 ! secretory granule relationship: part_of CL:0000775 ! neutrophil +[Term] +id: GO:0042588 +name: zymogen granule +namespace: cellular_component +def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042589 +name: zymogen granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] +is_a: GO:0030667 ! secretory granule membrane +intersection_of: GO:0016020 ! membrane +intersection_of: bounding_layer_of GO:0042588 ! zymogen granule +relationship: bounding_layer_of GO:0042588 ! zymogen granule +relationship: part_of GO:0042588 ! zymogen granule + [Term] id: GO:0042592 name: homeostatic process @@ -64260,6 +96475,9 @@ name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] is_a: GO:0033500 ! carbohydrate homeostasis +intersection_of: GO:0048878 ! chemical homeostasis +intersection_of: regulates_levels_of CHEBI:17234 ! glucose +relationship: regulates_levels_of CHEBI:17234 ! glucose [Term] id: GO:0042599 @@ -64521,6 +96739,28 @@ namespace: biological_process def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: in_taxon NCBITaxon:2759 ! Eukaryota + +[Term] +id: GO:0042701 +name: progesterone secretion +def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0035929 ! steroid hormone secretion +relationship: part_of GO:0001553 ! luteinization + +[Term] +id: GO:0042702 +name: uterine wall growth +namespace: biological_process +def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0048589 ! developmental growth +intersection_of: GO:0040007 ! growth +intersection_of: results_in_growth_of UBERON:0000459 ! uterine wall +relationship: part_of GO:0001553 ! luteinization +relationship: results_in_growth_of UBERON:0000459 ! uterine wall [Term] id: GO:0042703 @@ -64548,6 +96788,25 @@ def: "A process that solubilizes fibrin in the bloodstream of a multicellular or xref: Wikipedia:Fibrinolysis is_a: GO:0030195 ! negative regulation of blood coagulation +[Term] +id: GO:0042742 +name: defense response to bacterium +namespace: biological_process +alt_id: GO:0009816 +alt_id: GO:0042830 +def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] +synonym: "antibacterial peptide activity" RELATED [] +synonym: "defence response to bacteria" EXACT [] +synonym: "defence response to bacterium" EXACT [] +synonym: "defense response to bacteria" EXACT [] +synonym: "defense response to bacterium, incompatible interaction" NARROW [] +synonym: "resistance response to pathogenic bacteria" NARROW [] +synonym: "resistance response to pathogenic bacterium" NARROW [] +is_a: GO:0009617 ! response to bacterium +is_a: GO:0098542 ! defense response to other organism +intersection_of: GO:0006952 ! defense response +intersection_of: has_input NCBITaxon:2 ! Bacteria + [Term] id: GO:0042752 name: regulation of circadian rhythm @@ -64587,6 +96846,18 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006790 ! sulfur compound metabolic process relationship: regulates GO:0006790 ! sulfur compound metabolic process +[Term] +id: GO:0042776 +name: proton motive force-driven mitochondrial ATP synthesis +def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [] +synonym: "mitochondrial ATP synthesis coupled proton transport" EXACT [] +synonym: "mitochondrial proton transport" BROAD [] +is_a: GO:0015986 ! proton motive force-driven ATP synthesis +intersection_of: GO:0015986 ! proton motive force-driven ATP synthesis +intersection_of: occurs_in GO:0005739 ! mitochondrion +relationship: occurs_in GO:0005739 ! mitochondrion +relationship: part_of GO:0006119 ! oxidative phosphorylation + [Term] id: GO:0042827 name: platelet dense granule @@ -64604,8 +96875,20 @@ def: "The directed movement of an amide, any compound containing one, two, or th subset: goslim_pir is_a: GO:0071705 ! nitrogen compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:32988 ! amide -relationship: transports_or_maintains_localization_of CHEBI:32988 ! amide +intersection_of: has_primary_input CHEBI:32988 ! amide +relationship: has_primary_input CHEBI:32988 ! amide + +[Term] +id: GO:0042887 +name: amide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] +synonym: "amine/amide/polyamine channel activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:32988 ! amide +relationship: has_primary_input CHEBI:32988 ! amide +relationship: part_of GO:0042886 ! amide transport [Term] id: GO:0042923 @@ -64636,6 +96919,7 @@ subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir +subset: prokaryote_subset synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] @@ -64717,6 +97001,7 @@ is_a: GO:0120025 ! plasma membrane bounded cell projection intersection_of: GO:0120025 ! plasma membrane bounded cell projection intersection_of: part_of CL:0000540 ! neuron relationship: part_of CL:0000540 ! neuron +property_value: RO:0002161 NCBITaxon:4751 [Term] id: GO:0043009 @@ -64876,6 +97161,7 @@ name: extracellular structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir +subset: prokaryote_subset synonym: "extracellular structure organisation" EXACT [] synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization @@ -65038,6 +97324,35 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity +[Term] +id: GO:0043129 +name: surfactant homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757] +is_a: GO:0048875 ! chemical homeostasis within a tissue + +[Term] +id: GO:0043133 +name: hindgut contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] +is_a: GO:0006939 ! smooth muscle contraction +is_a: GO:0022600 ! digestive system process +intersection_of: GO:0006939 ! smooth muscle contraction +intersection_of: occurs_in UBERON:0001046 ! hindgut +relationship: occurs_in UBERON:0001046 ! hindgut + +[Term] +id: GO:0043134 +name: regulation of hindgut contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0044058 ! regulation of digestive system process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0043133 ! hindgut contraction +relationship: regulates GO:0043133 ! hindgut contraction + [Term] id: GO:0043143 name: regulation of translation by machinery localization @@ -65106,6 +97421,21 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:33694 ! biomacromolecule relationship: has_primary_input_or_output CHEBI:33694 ! biomacromolecule +[Term] +id: GO:0043171 +name: peptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] +synonym: "peptide breakdown" EXACT [] +synonym: "peptide catabolism" EXACT [] +synonym: "peptide degradation" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:16670 ! peptide +relationship: has_primary_input CHEBI:16670 ! peptide + [Term] id: GO:0043176 name: amine binding @@ -65259,6 +97589,7 @@ def: "Organized structure of distinctive morphology and function. Includes the n subset: goslim_chembl subset: goslim_generic subset: goslim_pir +subset: prokaryote_subset xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0110165 ! cellular anatomical entity @@ -65281,6 +97612,7 @@ id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +subset: goslim_mouse synonym: "biological condensate" NARROW [] synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 @@ -65327,7 +97659,6 @@ id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] -subset: goslim_mouse subset: goslim_pir synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle @@ -65340,6 +97671,7 @@ id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] +subset: goslim_mouse is_a: GO:0031974 ! membrane-enclosed lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043226 ! organelle @@ -65400,6 +97732,19 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032984 ! protein-containing complex disassembly relationship: regulates GO:0032984 ! protein-containing complex disassembly +[Term] +id: GO:0043249 +name: erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] +synonym: "RBC maturation" EXACT [CL:0000232] +synonym: "red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000232 ! erythrocyte +relationship: part_of GO:0048821 ! erythrocyte development +relationship: results_in_maturation_of CL:0000232 ! erythrocyte + [Term] id: GO:0043254 name: regulation of protein-containing complex assembly @@ -65734,6 +98079,32 @@ intersection_of: GO:0030154 ! cell differentiation intersection_of: results_in_acquisition_of_features_of CL:0000595 ! enucleate erythrocyte relationship: results_in_acquisition_of_features_of CL:0000595 ! enucleate erythrocyte +[Term] +id: GO:0043354 +name: enucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] +synonym: "enucleate RBC maturation" EXACT [CL:0000232] +synonym: "enucleate red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0043249 ! erythrocyte maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000595 ! enucleate erythrocyte +relationship: part_of GO:0048822 ! enucleate erythrocyte development +relationship: results_in_maturation_of CL:0000595 ! enucleate erythrocyte + +[Term] +id: GO:0043362 +name: nucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] +synonym: "nucleate RBC maturation" EXACT [CL:0000232] +synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0043249 ! erythrocyte maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000562 ! nucleate erythrocyte +relationship: part_of GO:0048823 ! nucleate erythrocyte development +relationship: results_in_maturation_of CL:0000562 ! nucleate erythrocyte + [Term] id: GO:0043363 name: nucleate erythrocyte differentiation @@ -65850,35 +98221,15 @@ synonym: "negative T-lymphocyte selection" EXACT [] is_a: GO:0045058 ! T cell selection [Term] -id: GO:0043388 -name: positive regulation of DNA binding -namespace: biological_process -def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] -synonym: "activation of DNA binding" NARROW [] -synonym: "stimulation of DNA binding" NARROW [] -synonym: "up regulation of DNA binding" EXACT [] -synonym: "up-regulation of DNA binding" EXACT [] -synonym: "upregulation of DNA binding" EXACT [] -is_a: GO:0051099 ! positive regulation of binding -is_a: GO:0051101 ! regulation of DNA binding -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0003677 ! DNA binding -relationship: positively_regulates GO:0003677 ! DNA binding - -[Term] -id: GO:0043392 -name: negative regulation of DNA binding -namespace: biological_process -def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] -synonym: "down regulation of DNA binding" EXACT [] -synonym: "down-regulation of DNA binding" EXACT [] -synonym: "downregulation of DNA binding" EXACT [] -synonym: "inhibition of DNA binding" NARROW [] -is_a: GO:0051100 ! negative regulation of binding -is_a: GO:0051101 ! regulation of DNA binding -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0003677 ! DNA binding -relationship: negatively_regulates GO:0003677 ! DNA binding +id: GO:0043384 +name: pre-T cell receptor complex +def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [] +synonym: "pre-T lymphocyte receptor complex" EXACT [] +synonym: "pre-T-cell receptor complex" EXACT [] +synonym: "pre-T-lymphocyte receptor complex" EXACT [] +synonym: "pre-TCR complex" EXACT [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0043393 @@ -65917,7 +98268,7 @@ relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion id: GO:0043401 name: steroid hormone mediated signaling pathway namespace: biological_process -def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] +def: "The series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] synonym: "steroid hormone mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus @@ -66282,6 +98633,18 @@ intersection_of: part_of GO:0033554 ! cellular response to stress intersection_of: regulates GO:0006412 ! translation relationship: part_of GO:0033554 ! cellular response to stress +[Term] +id: GO:0043559 +name: insulin binding +namespace: molecular_function +def: "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732] +is_a: GO:0005515 ! protein binding +is_a: GO:0017046 ! peptide hormone binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input PR:000009054 ! insulin gene translation product +relationship: has_input PR:000009054 ! insulin gene translation product +property_value: RO:0002161 NCBITaxon:4751 + [Term] id: GO:0043576 name: regulation of respiratory gaseous exchange @@ -66396,6 +98759,22 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:35693 ! dicarboxylic acid anion relationship: has_primary_input_or_output CHEBI:35693 ! dicarboxylic acid anion +[Term] +id: GO:0043649 +name: dicarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "dicarboxylate catabolic process" EXACT [] +synonym: "dicarboxylate catabolism" EXACT [] +synonym: "dicarboxylic acid breakdown" EXACT [] +synonym: "dicarboxylic acid catabolism" EXACT [] +synonym: "dicarboxylic acid degradation" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:35693 ! dicarboxylic acid anion +relationship: has_primary_input CHEBI:35693 ! dicarboxylic acid anion + [Term] id: GO:0043650 name: dicarboxylic acid biosynthetic process @@ -66495,6 +98874,9 @@ namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output CHEBI:37163 ! glucan +relationship: has_primary_input_or_output CHEBI:37163 ! glucan [Term] id: GO:0044057 @@ -66758,6 +99140,19 @@ synonym: "cellular lipid metabolism" EXACT [] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process +[Term] +id: GO:0044258 +name: intestinal lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/] +synonym: "intestinal lipid breakdown" EXACT [] +synonym: "intestinal lipid catabolism" EXACT [] +synonym: "intestinal lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +intersection_of: GO:0016042 ! lipid catabolic process +intersection_of: occurs_in UBERON:0000160 ! intestine +relationship: occurs_in UBERON:0000160 ! intestine + [Term] id: GO:0044260 name: cellular macromolecule metabolic process @@ -66793,15 +99188,39 @@ is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process +[Term] +id: GO:0044265 +name: cellular macromolecule catabolic process +namespace: biological_process +alt_id: GO:0034962 +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [GOC:jl] +synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "cellular macromolecule breakdown" EXACT [] +synonym: "cellular macromolecule catabolism" EXACT [] +synonym: "cellular macromolecule degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + [Term] id: GO:0044267 name: cellular protein metabolic process -namespace: biological_process -def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] +def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [] synonym: "cellular protein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process +[Term] +id: GO:0044270 +name: cellular nitrogen compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] +synonym: "nitrogen compound breakdown" BROAD [] +synonym: "nitrogen compound catabolism" BROAD [] +synonym: "nitrogen compound degradation" BROAD [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process @@ -66831,6 +99250,22 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:26835 ! sulfur molecular entity relationship: has_primary_output CHEBI:26835 ! sulfur molecular entity +[Term] +id: GO:0044273 +name: sulfur compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] +synonym: "sulfur catabolic process" NARROW [] +synonym: "sulfur catabolism" NARROW [] +synonym: "sulfur compound breakdown" EXACT [] +synonym: "sulfur compound catabolism" EXACT [] +synonym: "sulfur compound degradation" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0044248 ! cellular catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity +relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity + [Term] id: GO:0044275 name: cellular carbohydrate catabolic process @@ -66875,6 +99310,7 @@ name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. +subset: prokaryote_subset synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044281 ! small molecule metabolic process @@ -66968,6 +99404,9 @@ def: "The multiplication or reproduction of pancreatic B cells, resulting in the synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] synonym: "pancreatic beta cell proliferation" EXACT [] is_a: GO:0050673 ! epithelial cell proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:0000169 ! type B pancreatic cell +relationship: acts_on_population_of CL:0000169 ! type B pancreatic cell created_by: jl creation_date: 2010-08-25T01:44:51Z @@ -66997,6 +99436,14 @@ relationship: has_target_end_location GO:0005856 ! cytoskeleton created_by: jl creation_date: 2011-12-13T11:43:24Z +[Term] +id: GO:0044381 +name: glucose import in response to insulin stimulus +def: "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [] +synonym: "cellular glucose import in response to insulin stimulus" EXACT [] +is_a: GO:0046323 ! glucose import +relationship: part_of GO:0032869 ! cellular response to insulin stimulus + [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms @@ -67032,11 +99479,23 @@ relationship: results_in_assembly_of GO:0031514 ! motile cilium created_by: krc creation_date: 2015-02-06T17:23:23Z +[Term] +id: GO:0044464 +name: cell part +name: obsolete cell part +def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [] +synonym: "cellular subcomponent" EXACT [] +synonym: "protoplast" RELATED [] +is_a: CARO:0000003 ! connected anatomical structure +is_obsolete: true +consider: CL:0000000 + [Term] id: GO:0044550 name: secondary metabolite biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] +subset: prokaryote_subset synonym: "secondary metabolite biosynthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0019748 ! secondary metabolic process @@ -67048,7 +99507,7 @@ id: GO:0044565 name: dendritic cell proliferation namespace: biological_process def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816] -is_a: GO:0046651 ! lymphocyte proliferation +is_a: GO:0032943 ! mononuclear cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: acts_on_population_of CL:0000451 ! dendritic cell relationship: acts_on_population_of CL:0000451 ! dendritic cell @@ -67190,8 +99649,8 @@ namespace: cellular_component def: "A protein complex that plays a role in the process of DNA packaging." [GOC:jl] is_a: GO:0032991 ! protein-containing complex intersection_of: GO:0032991 ! protein-containing complex -intersection_of: capable_of_part_of GO:0006323 ! DNA packaging -relationship: capable_of_part_of GO:0006323 ! DNA packaging +intersection_of: capable_of_part_of GO:0051276 ! chromosome organization +relationship: capable_of_part_of GO:0051276 ! chromosome organization created_by: jl creation_date: 2013-09-19T11:33:45Z @@ -67343,6 +99802,20 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045087 ! innate immune response relationship: positively_regulates GO:0045087 ! innate immune response +[Term] +id: GO:0045095 +name: keratin filament +def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [] +synonym: "acidic keratin" RELATED [] +synonym: "basic/neutral keratin" RELATED [] +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0045111 +name: intermediate filament cytoskeleton +def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [] +is_a: GO:0005856 ! cytoskeleton + [Term] id: GO:0045123 name: cellular extravasation @@ -67393,6 +99866,18 @@ is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007275 ! multicellular organism development relationship: part_of GO:0007548 ! sex differentiation +[Term] +id: GO:0045144 +name: meiotic sister chromatid segregation +def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [] +synonym: "meiosis II, chromosome segregation" EXACT [] +is_a: GO:0000819 ! sister chromatid segregation +is_a: GO:0045132 ! meiotic chromosome segregation +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +intersection_of: GO:0000819 ! sister chromatid segregation +intersection_of: part_of GO:0007135 ! meiosis II +relationship: part_of GO:0007135 ! meiosis II + [Term] id: GO:0045161 name: neuronal ion channel clustering @@ -67432,12 +99917,12 @@ id: GO:0045182 name: translation regulator activity namespace: molecular_function def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_plant +subset: prokaryote_subset synonym: "translation factor activity" EXACT [] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function @@ -67455,7 +99940,7 @@ synonym: "protein recruitment" EXACT [] is_a: GO:0008104 ! protein localization is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization -intersection_of: transports_or_maintains_localization_of CHEBI:36080 ! protein +intersection_of: has_primary_input CHEBI:36080 ! protein [Term] id: GO:0045190 @@ -67486,6 +99971,31 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045190 ! isotype switching relationship: regulates GO:0045190 ! isotype switching +[Term] +id: GO:0045196 +name: establishment or maintenance of neuroblast polarity +namespace: biological_process +alt_id: GO:0043339 +alt_id: GO:0043342 +def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] +synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0055059 ! asymmetric neuroblast division + +[Term] +id: GO:0045200 +name: establishment of neuroblast polarity +namespace: biological_process +alt_id: GO:0043340 +alt_id: GO:0043343 +def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] +synonym: "establishment of neuroblast cell polarity" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: occurs_in CL:0000031 ! neuroblast (sensu Vertebrata) +relationship: occurs_in CL:0000031 ! neuroblast (sensu Vertebrata) + [Term] id: GO:0045202 name: synapse @@ -67696,7 +100206,6 @@ id: GO:0045333 name: cellular respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] -subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast @@ -68478,6 +100987,44 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030099 ! myeloid cell differentiation relationship: positively_regulates GO:0030099 ! myeloid cell differentiation +[Term] +id: GO:0045640 +name: regulation of basophil differentiation +def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [] +is_a: GO:0030852 ! regulation of granulocyte differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0030221 ! basophil differentiation +relationship: regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045641 +name: negative regulation of basophil differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [] +synonym: "down regulation of basophil differentiation" EXACT [] +synonym: "down-regulation of basophil differentiation" EXACT [] +synonym: "downregulation of basophil differentiation" EXACT [] +synonym: "inhibition of basophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0030221 ! basophil differentiation +relationship: negatively_regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045642 +name: positive regulation of basophil differentiation +def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [] +synonym: "activation of basophil differentiation" NARROW [] +synonym: "stimulation of basophil differentiation" NARROW [] +synonym: "up regulation of basophil differentiation" EXACT [] +synonym: "up-regulation of basophil differentiation" EXACT [] +synonym: "upregulation of basophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0030221 ! basophil differentiation +relationship: positively_regulates GO:0030221 ! basophil differentiation + [Term] id: GO:0045646 name: regulation of erythrocyte differentiation @@ -68949,6 +101496,71 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010001 ! glial cell differentiation relationship: positively_regulates GO:0010001 ! glial cell differentiation +[Term] +id: GO:0045700 +name: regulation of spermatid nuclear differentiation +def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:1903353 ! regulation of nucleus organization +is_a: GO:2000241 ! regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0007289 ! spermatid nucleus differentiation +relationship: regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045701 +name: negative regulation of spermatid nuclear differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [] +synonym: "down regulation of spermatid nuclear differentiation" EXACT [] +synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "downregulation of spermatid nuclear differentiation" EXACT [] +synonym: "inhibition of spermatid nuclear differentiation" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0007289 ! spermatid nucleus differentiation +relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045702 +name: positive regulation of spermatid nuclear differentiation +def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [] +synonym: "activation of spermatid nuclear differentiation" NARROW [] +synonym: "stimulation of spermatid nuclear differentiation" NARROW [] +synonym: "up regulation of spermatid nuclear differentiation" EXACT [] +synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "upregulation of spermatid nuclear differentiation" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +is_a: GO:2000243 ! positive regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0007289 ! spermatid nucleus differentiation +relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045719 +name: negative regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "down regulation of glycogen biosynthetic process" EXACT [] +synonym: "down-regulation of glycogen biosynthetic process" EXACT [] +synonym: "downregulation of glycogen biosynthetic process" EXACT [] +synonym: "inhibition of glycogen biosynthetic process" NARROW [] +synonym: "negative regulation of glycogen anabolism" EXACT [] +synonym: "negative regulation of glycogen biosynthesis" EXACT [] +synonym: "negative regulation of glycogen formation" EXACT [] +synonym: "negative regulation of glycogen synthesis" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0070874 ! negative regulation of glycogen metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0005978 ! glycogen biosynthetic process +relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process + [Term] id: GO:0045721 name: negative regulation of gluconeogenesis @@ -69002,6 +101614,28 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060271 ! cilium assembly relationship: positively_regulates GO:0060271 ! cilium assembly +[Term] +id: GO:0045725 +name: positive regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "activation of glycogen biosynthetic process" NARROW [] +synonym: "positive regulation of glycogen anabolism" EXACT [] +synonym: "positive regulation of glycogen biosynthesis" EXACT [] +synonym: "positive regulation of glycogen formation" EXACT [] +synonym: "positive regulation of glycogen synthesis" EXACT [] +synonym: "stimulation of glycogen biosynthetic process" NARROW [] +synonym: "up regulation of glycogen biosynthetic process" EXACT [] +synonym: "up-regulation of glycogen biosynthetic process" EXACT [] +synonym: "upregulation of glycogen biosynthetic process" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0070875 ! positive regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0005978 ! glycogen biosynthetic process +relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process + [Term] id: GO:0045727 name: positive regulation of translation @@ -69028,6 +101662,84 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006412 ! translation relationship: positively_regulates GO:0006412 ! translation +[Term] +id: GO:0045732 +name: positive regulation of protein catabolic process +namespace: biological_process +alt_id: GO:1903364 +alt_id: GO:2000600 +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] +synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of protein catabolic process" NARROW [] +synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolic process" EXACT [] +synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] +synonym: "positive regulation of cyclin catabolic process" NARROW [] +synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] +synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] +synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] +synonym: "positive regulation of protein breakdown" EXACT [] +synonym: "positive regulation of protein catabolism" EXACT [] +synonym: "positive regulation of protein degradation" EXACT [] +synonym: "stimulation of protein catabolic process" NARROW [] +synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein catabolic process" EXACT [] +synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein catabolic process" EXACT [] +synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0030163 ! protein catabolic process +relationship: positively_regulates GO:0030163 ! protein catabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI + +[Term] +id: GO:0045733 +name: acetate catabolic process +namespace: biological_process +alt_id: GO:0019663 +def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "acetate breakdown" EXACT [] +synonym: "acetate catabolism" EXACT [] +synonym: "acetate degradation" EXACT [] +synonym: "homoacetate catabolic process" RELATED [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:30089 ! acetate +relationship: has_primary_input CHEBI:30089 ! acetate + +[Term] +id: GO:0045734 +name: regulation of acetate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "regulation of acetate breakdown" EXACT [] +synonym: "regulation of acetate catabolism" EXACT [] +synonym: "regulation of acetate degradation" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0045733 ! acetate catabolic process +relationship: regulates GO:0045733 ! acetate catabolic process + [Term] id: GO:0045738 name: negative regulation of DNA repair @@ -69107,6 +101819,45 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway relationship: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway +[Term] +id: GO:0045753 +name: negative regulation of acetate catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "down regulation of acetate catabolic process" EXACT [] +synonym: "down-regulation of acetate catabolic process" EXACT [] +synonym: "downregulation of acetate catabolic process" EXACT [] +synonym: "inhibition of acetate catabolic process" NARROW [] +synonym: "negative regulation of acetate breakdown" EXACT [] +synonym: "negative regulation of acetate catabolism" EXACT [] +synonym: "negative regulation of acetate degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0045733 ! acetate catabolic process +relationship: negatively_regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045754 +name: positive regulation of acetate catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "activation of acetate catabolic process" NARROW [] +synonym: "positive regulation of acetate breakdown" EXACT [] +synonym: "positive regulation of acetate catabolism" EXACT [] +synonym: "positive regulation of acetate degradation" EXACT [] +synonym: "stimulation of acetate catabolic process" NARROW [] +synonym: "up regulation of acetate catabolic process" EXACT [] +synonym: "up-regulation of acetate catabolic process" EXACT [] +synonym: "upregulation of acetate catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0045733 ! acetate catabolic process +relationship: positively_regulates GO:0045733 ! acetate catabolic process + [Term] id: GO:0045759 name: negative regulation of action potential @@ -69386,53 +102137,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030299 ! intestinal cholesterol absorption relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption -[Term] -id: GO:0045798 -name: negative regulation of chromatin assembly or disassembly -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] -synonym: "down regulation of chromatin assembly or disassembly" EXACT [] -synonym: "down-regulation of chromatin assembly or disassembly" EXACT [] -synonym: "downregulation of chromatin assembly or disassembly" EXACT [] -synonym: "inhibition of chromatin assembly or disassembly" NARROW [] -synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] -is_a: GO:0001672 ! regulation of chromatin assembly or disassembly -is_a: GO:1905268 ! negative regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0006333 ! chromatin assembly or disassembly -relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly - -[Term] -id: GO:0045799 -name: positive regulation of chromatin assembly or disassembly -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] -synonym: "activation of chromatin assembly or disassembly" NARROW [] -synonym: "positive regulation of chromatin assembly/disassembly" EXACT [] -synonym: "stimulation of chromatin assembly or disassembly" NARROW [] -synonym: "up regulation of chromatin assembly or disassembly" EXACT [] -synonym: "up-regulation of chromatin assembly or disassembly" EXACT [] -synonym: "upregulation of chromatin assembly or disassembly" EXACT [] -is_a: GO:0001672 ! regulation of chromatin assembly or disassembly -is_a: GO:1905269 ! positive regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0006333 ! chromatin assembly or disassembly -relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly - -[Term] -id: GO:0045814 -name: negative regulation of gene expression, epigenetic -namespace: biological_process -def: "An epigenetic process that stops, prevents or reduces the rate of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:22243696] -synonym: "down regulation of gene expression, epigenetic" EXACT [] -synonym: "down-regulation of gene expression, epigenetic" EXACT [] -synonym: "downregulation of gene expression, epigenetic" EXACT [] -synonym: "gene silencing" RELATED [] -synonym: "inhibition of gene expression, epigenetic" NARROW [] -is_a: GO:0010629 ! negative regulation of gene expression -is_a: GO:0040029 ! regulation of gene expression, epigenetic -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22201 xsd:anyURI - [Term] id: GO:0045815 name: epigenetic maintenance of chromatin in transcription-competent conformation @@ -69442,6 +102146,7 @@ def: "An epigenetic process that capacitates gene expression by remodelling of c comment: This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. Do not confuse with GO:0140673 ; co-transcriptional chromatin reassembly, which describes the reforming of chromatin after RNA polymerase II passage. synonym: "activation of gene expression, epigenetic" RELATED [] synonym: "chromatin-mediated maintenance of transcription" EXACT [] +synonym: "DNA replication-independent chromatin organization" RELATED [] synonym: "euchromatin assembly" RELATED [] synonym: "euchromatin organisation" RELATED [] synonym: "euchromatin organization" RELATED [] @@ -69452,9 +102157,10 @@ synonym: "stimulation of gene expression, epigenetic" RELATED [] synonym: "up regulation of gene expression, epigenetic" EXACT [] synonym: "up-regulation of gene expression, epigenetic" EXACT [] synonym: "upregulation of gene expression, epigenetic" EXACT [] +is_a: GO:0006338 ! chromatin remodeling is_a: GO:0010628 ! positive regulation of gene expression -is_a: GO:0040029 ! regulation of gene expression, epigenetic -intersection_of: GO:0040029 ! regulation of gene expression, epigenetic +is_a: GO:0040029 ! epigenetic regulation of gene expression +intersection_of: GO:0040029 ! epigenetic regulation of gene expression intersection_of: positively_regulates GO:0010467 ! gene expression property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21730 xsd:anyURI property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22012 xsd:anyURI @@ -69513,7 +102219,6 @@ is_a: GO:0006110 ! regulation of glycolytic process is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0042326 ! negative regulation of phosphorylation -is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1903579 ! negative regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006096 ! glycolytic process @@ -69533,7 +102238,6 @@ is_a: GO:0006110 ! regulation of glycolytic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0042327 ! positive regulation of phosphorylation is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process -is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1903580 ! positive regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006096 ! glycolytic process @@ -69810,6 +102514,54 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0014706 ! striated muscle tissue development relationship: positively_regulates GO:0014706 ! striated muscle tissue development +[Term] +id: GO:0045851 +name: pH reduction +namespace: biological_process +def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +synonym: "acidification" EXACT [] +is_a: GO:0006885 ! regulation of pH +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates_characteristic PATO:0001842 ! acidity +relationship: negatively_regulates_characteristic PATO:0001842 ! acidity + +[Term] +id: GO:0045852 +name: pH elevation +namespace: biological_process +def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +is_a: GO:0006885 ! regulation of pH +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates_characteristic PATO:0001842 ! acidity +relationship: positively_regulates_characteristic PATO:0001842 ! acidity + +[Term] +id: GO:0045859 +name: regulation of protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0043549 ! regulation of kinase activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0004672 ! protein kinase activity +relationship: regulates GO:0004672 ! protein kinase activity + +[Term] +id: GO:0045860 +name: positive regulation of protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +synonym: "stimulation of protein kinase activity" NARROW [] +synonym: "up regulation of protein kinase activity" EXACT [] +synonym: "up-regulation of protein kinase activity" EXACT [] +synonym: "upregulation of protein kinase activity" EXACT [] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0004672 ! protein kinase activity +relationship: positively_regulates GO:0004672 ! protein kinase activity + [Term] id: GO:0045900 name: negative regulation of translational elongation @@ -70767,7 +103519,8 @@ name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] synonym: "ATP metabolism" EXACT [] -is_a: GO:0008152 ! metabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0046110 @@ -70794,6 +103547,22 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18282 ! nucleobase relationship: has_primary_output CHEBI:18282 ! nucleobase +[Term] +id: GO:0046113 +name: nucleobase catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] +synonym: "nucleobase breakdown" EXACT [] +synonym: "nucleobase catabolism" EXACT [] +synonym: "nucleobase degradation" EXACT [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18282 ! nucleobase +relationship: has_primary_input CHEBI:18282 ! nucleobase + [Term] id: GO:0046136 name: positive regulation of vitamin metabolic process @@ -70948,6 +103717,36 @@ synonym: "monosaccharide synthesis" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: has_primary_output CHEBI:35381 ! monosaccharide +relationship: has_primary_output CHEBI:35381 ! monosaccharide + +[Term] +id: GO:0046365 +name: monosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] +synonym: "monosaccharide breakdown" EXACT [] +synonym: "monosaccharide catabolism" EXACT [] +synonym: "monosaccharide degradation" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0044282 ! small molecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:35381 ! monosaccharide +relationship: has_primary_input CHEBI:35381 ! monosaccharide + +[Term] +id: GO:0046390 +name: ribose phosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [] +synonym: "ribose phosphate anabolism" EXACT [] +synonym: "ribose phosphate biosynthesis" EXACT [] +synonym: "ribose phosphate formation" EXACT [] +synonym: "ribose phosphate synthesis" EXACT [] +is_a: GO:0019693 ! ribose phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0046394 @@ -70964,6 +103763,20 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:29067 ! carboxylic acid anion relationship: has_primary_output CHEBI:29067 ! carboxylic acid anion +[Term] +id: GO:0046395 +name: carboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "carboxylic acid breakdown" EXACT [] +synonym: "carboxylic acid catabolism" EXACT [] +synonym: "carboxylic acid degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion +relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion + [Term] id: GO:0046483 name: heterocycle metabolic process @@ -71161,6 +103974,54 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035265 ! organ growth relationship: positively_regulates GO:0035265 ! organ growth +[Term] +id: GO:0046626 +name: regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0008286 ! insulin receptor signaling pathway +relationship: in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046627 +name: negative regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "down regulation of insulin receptor signaling pathway" EXACT [] +synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "downregulation of insulin receptor signaling pathway" EXACT [] +synonym: "inhibition of insulin receptor signaling pathway" NARROW [] +synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0008286 ! insulin receptor signaling pathway +relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046628 +name: positive regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "activation of insulin receptor signaling pathway" NARROW [] +synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] +synonym: "stimulation of insulin receptor signaling pathway" NARROW [] +synonym: "up regulation of insulin receptor signaling pathway" EXACT [] +synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "upregulation of insulin receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0008286 ! insulin receptor signaling pathway +relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway + [Term] id: GO:0046631 name: alpha-beta T cell activation @@ -71476,6 +104337,20 @@ intersection_of: GO:0050896 ! response to stimulus intersection_of: has_input CHEBI:13941 ! carbamate relationship: has_input CHEBI:13941 ! carbamate +[Term] +id: GO:0046700 +name: heterocycle catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] +synonym: "heterocycle breakdown" EXACT [] +synonym: "heterocycle catabolism" EXACT [] +synonym: "heterocycle degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0046483 ! heterocycle metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:5686 ! heterocyclic compound +relationship: has_primary_input CHEBI:5686 ! heterocyclic compound + [Term] id: GO:0046716 name: muscle cell cellular homeostasis @@ -71586,6 +104461,23 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input CHEBI:25213 ! metal cation relationship: has_input CHEBI:25213 ! metal cation +[Term] +id: GO:0046873 +name: metal ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] +synonym: "heavy metal ion porter activity" NARROW [] +synonym: "heavy metal ion transporter activity" NARROW [] +synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] +synonym: "heavy metal-exporting ATPase activity" NARROW [] +synonym: "high affinity metal ion uptake transporter activity" NARROW [] +synonym: "low affinity metal ion uptake transporter activity" NARROW [] +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:25213 ! metal cation +relationship: has_primary_input CHEBI:25213 ! metal cation +relationship: part_of GO:0030001 ! metal ion transport + [Term] id: GO:0046877 name: regulation of saliva secretion @@ -71691,6 +104583,40 @@ synonym: "follitropin secretion" EXACT [] synonym: "FSH secretion" EXACT [] is_a: GO:0032274 ! gonadotropin secretion +[Term] +id: GO:0046885 +name: regulation of hormone biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [] +synonym: "regulation of hormone anabolism" EXACT [] +synonym: "regulation of hormone biosynthesis" EXACT [] +synonym: "regulation of hormone formation" EXACT [] +synonym: "regulation of hormone synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032350 ! regulation of hormone metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0042446 ! hormone biosynthetic process +relationship: regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0046886 +name: positive regulation of hormone biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [] +synonym: "activation of hormone biosynthetic process" NARROW [] +synonym: "positive regulation of hormone anabolism" EXACT [] +synonym: "positive regulation of hormone biosynthesis" EXACT [] +synonym: "positive regulation of hormone formation" EXACT [] +synonym: "positive regulation of hormone synthesis" EXACT [] +synonym: "stimulation of hormone biosynthetic process" NARROW [] +synonym: "up regulation of hormone biosynthetic process" EXACT [] +synonym: "up-regulation of hormone biosynthetic process" EXACT [] +synonym: "upregulation of hormone biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0042446 ! hormone biosynthetic process +relationship: positively_regulates GO:0042446 ! hormone biosynthetic process + [Term] id: GO:0046887 name: positive regulation of hormone secretion @@ -71772,6 +104698,20 @@ def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport +[Term] +id: GO:0046906 +name: tetrapyrrole binding +namespace: molecular_function +def: "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "porphyrin binding" NARROW [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:26932 ! tetrapyrrole +relationship: has_input CHEBI:26932 ! tetrapyrrole + [Term] id: GO:0046907 name: intracellular transport @@ -71799,6 +104739,17 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input CHEBI:33515 ! transition element cation relationship: has_input CHEBI:33515 ! transition element cation +[Term] +id: GO:0046915 +name: transition metal ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] +is_a: GO:0046873 ! metal ion transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33515 ! transition element cation +relationship: has_primary_input CHEBI:33515 ! transition element cation +relationship: part_of GO:0000041 ! transition metal ion transport + [Term] id: GO:0046916 name: cellular transition metal ion homeostasis @@ -71866,8 +104817,20 @@ namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] is_a: GO:0015711 ! organic anion transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:29067 ! carboxylic acid anion -relationship: transports_or_maintains_localization_of CHEBI:29067 ! carboxylic acid anion +intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion +relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion + +[Term] +id: GO:0046943 +name: carboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] +xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" +is_a: GO:0005342 ! organic acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33575 ! carboxylic acid +relationship: has_primary_input CHEBI:33575 ! carboxylic acid +relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0046950 @@ -71903,8 +104866,8 @@ synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:0099518 ! vesicle cytoskeletal trafficking intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0031982 ! vesicle intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:0031982 ! vesicle [Term] id: GO:0048002 @@ -71915,6 +104878,18 @@ synonym: "antigen presentation, peptide antigen" EXACT [] synonym: "peptide antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation +[Term] +id: GO:0048018 +name: receptor ligand activity +def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [] +synonym: "receptor agonist activity" BROAD [] +synonym: "signaling molecule" EXACT [] +synonym: "signaling receptor ligand activity" EXACT [] +synonym: "vitamin D receptor activator activity" NARROW [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0030546 ! signaling receptor activator activity +relationship: part_of GO:0007165 ! signal transduction + [Term] id: GO:0048021 name: regulation of melanin biosynthetic process @@ -71971,6 +104946,17 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042438 ! melanin biosynthetic process relationship: positively_regulates GO:0042438 ! melanin biosynthetic process +[Term] +id: GO:0048029 +name: monosaccharide binding +namespace: molecular_function +def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] +is_a: GO:0030246 ! carbohydrate binding +is_a: GO:0036094 ! small molecule binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:35381 ! monosaccharide +relationship: has_input CHEBI:35381 ! monosaccharide + [Term] id: GO:0048048 name: embryonic eye morphogenesis @@ -72089,6 +105075,30 @@ intersection_of: GO:0051301 ! cell division intersection_of: has_input CL:0000723 ! somatic stem cell relationship: has_input CL:0000723 ! somatic stem cell +[Term] +id: GO:0048132 +name: female germ-line stem cell asymmetric division +namespace: biological_process +alt_id: GO:0048141 +def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] +synonym: "female germ-line stem cell renewal" EXACT [] +is_a: GO:0098728 ! germline stem cell asymmetric division +intersection_of: GO:0008356 ! asymmetric cell division +intersection_of: has_input CL:0000022 ! female germ line stem cell +relationship: has_input CL:0000022 ! female germ line stem cell +relationship: in_taxon NCBITaxon:6656 ! Arthropoda +relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0048137 +name: spermatocyte division +def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [] +synonym: "spermatocyte cell division" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051301 ! cell division +relationship: part_of GO:0007283 ! spermatogenesis + [Term] id: GO:0048144 name: fibroblast proliferation @@ -72179,11 +105189,11 @@ synonym: "Golgi vesicle targeting" EXACT [] synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] is_a: GO:0006903 ! vesicle targeting intersection_of: GO:0006903 ! vesicle targeting +intersection_of: has_primary_input GO:0005798 ! Golgi-associated vesicle intersection_of: results_in_transport_to_from_or_in GO:0005794 ! Golgi apparatus -intersection_of: transports_or_maintains_localization_of GO:0005798 ! Golgi-associated vesicle +relationship: has_primary_input GO:0005798 ! Golgi-associated vesicle relationship: part_of GO:0048193 ! Golgi vesicle transport relationship: results_in_transport_to_from_or_in GO:0005794 ! Golgi apparatus -relationship: transports_or_maintains_localization_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0048209 @@ -72242,7 +105252,7 @@ is_a: GO:0015874 ! norepinephrine transport is_a: GO:0023061 ! signal release is_a: GO:0050432 ! catecholamine secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:33569 ! noradrenaline +intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) [Term] id: GO:0048245 @@ -72549,7 +105559,10 @@ subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000000 ! cell relationship: part_of GO:0048468 ! cell development +relationship: results_in_maturation_of CL:0000000 ! cell [Term] id: GO:0048471 @@ -72571,6 +105584,11 @@ synonym: "ovum development" EXACT systematic_synonym [] xref: Wikipedia:Oogenesis is_a: GO:0007281 ! germ cell development is_a: GO:0007292 ! female gamete generation +intersection_of: GO:0048468 ! cell development +intersection_of: results_in_development_of CL:0000025 ! egg cell +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +relationship: results_in_development_of CL:0000025 ! egg cell [Term] id: GO:0048483 @@ -72622,6 +105640,8 @@ def: "Any process pertinent to the generation and maintenance of rhythms in the subset: goslim_pir synonym: "rhythm" RELATED [] is_a: GO:0008150 ! biological_process +relationship: in_taxon NCBITaxon:131567 ! cellular organisms +relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms [Term] id: GO:0048513 @@ -72634,7 +105654,6 @@ xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0000062 ! organ -relationship: part_of GO:0048731 ! system development relationship: results_in_development_of UBERON:0000062 ! organ [Term] @@ -72706,6 +105725,7 @@ synonym: "up-regulation of behavior" EXACT [] synonym: "upregulation of behavior" EXACT [] is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007610 ! behavior relationship: positively_regulates GO:0007610 ! behavior @@ -72721,6 +105741,7 @@ synonym: "downregulation of behavior" EXACT [] synonym: "inhibition of behavior" NARROW [] is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007610 ! behavior relationship: negatively_regulates GO:0007610 ! behavior @@ -72791,6 +105812,9 @@ name: spleen development namespace: biological_process def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] is_a: GO:0048534 ! hematopoietic or lymphoid organ development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002106 ! spleen +relationship: results_in_development_of UBERON:0002106 ! spleen [Term] id: GO:0048538 @@ -72994,8 +106018,10 @@ id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] -is_a: GO:0032502 ! developmental process is_a: GO:0040007 ! growth +intersection_of: GO:0040007 ! growth +intersection_of: part_of GO:0032502 ! developmental process +relationship: part_of GO:0032502 ! developmental process [Term] id: GO:0048592 @@ -73043,6 +106069,32 @@ synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009790 ! embryo development +[Term] +id: GO:0048599 +name: oocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] +is_a: GO:0007281 ! germ cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_development_of CL:0000023 ! oocyte +relationship: part_of GO:0009994 ! oocyte differentiation +relationship: results_in_development_of CL:0000023 ! oocyte + +[Term] +id: GO:0048601 +name: oocyte morphogenesis +namespace: biological_process +def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] +synonym: "oocyte morphogenesis during differentiation" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0003006 ! developmental process involved in reproduction +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of CL:0000023 ! oocyte +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +relationship: part_of GO:0048599 ! oocyte development +relationship: results_in_morphogenesis_of CL:0000023 ! oocyte + [Term] id: GO:0048608 name: reproductive structure development @@ -73050,10 +106102,8 @@ namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development -intersection_of: GO:0048856 ! anatomical structure development -intersection_of: results_in_development_of UBERON:0005156 ! reproductive structure relationship: part_of GO:0061458 ! reproductive system development -relationship: results_in_development_of UBERON:0005156 ! reproductive structure +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23445 xsd:anyURI [Term] id: GO:0048609 @@ -73076,6 +106126,17 @@ intersection_of: results_in_development_of CL:0000056 ! myoblast relationship: part_of GO:0045445 ! myoblast differentiation relationship: results_in_development_of CL:0000056 ! myoblast +[Term] +id: GO:0048628 +name: myoblast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0048469 ! cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000056 ! myoblast +relationship: part_of GO:0048627 ! myoblast development +relationship: results_in_maturation_of CL:0000056 ! myoblast + [Term] id: GO:0048630 name: skeletal muscle tissue growth @@ -73869,7 +106930,10 @@ name: animal organ maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] is_a: GO:0071695 ! anatomical structure maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0000062 ! organ relationship: part_of GO:0048513 ! animal organ development +relationship: results_in_maturation_of UBERON:0000062 ! organ [Term] id: GO:0048806 @@ -74143,6 +107207,9 @@ subset: goslim_generic subset: goslim_plant synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process +intersection_of: GO:0032502 ! developmental process +intersection_of: results_in_development_of UBERON:0000061 ! anatomical structure +relationship: results_in_development_of UBERON:0000061 ! anatomical structure [Term] id: GO:0048857 @@ -74173,8 +107240,8 @@ namespace: biological_process def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis -intersection_of: results_in_formation_of UBERON:0000015 ! non-material anatomical boundary -relationship: results_in_formation_of UBERON:0000015 ! non-material anatomical boundary +intersection_of: results_in_formation_of UBERON:0007651 ! anatomical junction +relationship: results_in_formation_of UBERON:0007651 ! anatomical junction [Term] id: GO:0048860 @@ -74224,12 +107291,14 @@ def: "Any process involved in the controlled self-propelled movement of a cell t subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic +subset: prokaryote_subset synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0040011 ! locomotion relationship: part_of GO:0051674 ! localization of cell +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0048871 @@ -74256,6 +107325,14 @@ def: "Any biological process involved in the maintenance of the steady-state num is_a: GO:0001894 ! tissue homeostasis is_a: GO:0048872 ! homeostasis of number of cells +[Term] +id: GO:0048875 +name: chemical homeostasis within a tissue +namespace: biological_process +def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete] +is_a: GO:0001894 ! tissue homeostasis +is_a: GO:0048878 ! chemical homeostasis + [Term] id: GO:0048878 name: chemical homeostasis @@ -74309,8 +107386,8 @@ synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005694 ! chromosome -relationship: transports_or_maintains_localization_of GO:0005694 ! chromosome +intersection_of: has_primary_input GO:0005694 ! chromosome +relationship: has_primary_input GO:0005694 ! chromosome [Term] id: GO:0050174 @@ -74334,7 +107411,7 @@ def: "The regulated release of catecholamines by a cell. The catecholamines are is_a: GO:0032940 ! secretion by cell is_a: GO:0051937 ! catecholamine transport intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:33567 ! catecholamine +intersection_of: has_primary_input CHEBI:33567 ! catecholamine [Term] id: GO:0050433 @@ -74354,8 +107431,8 @@ namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] is_a: GO:0015931 ! nucleobase-containing compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33696 ! nucleic acid -relationship: transports_or_maintains_localization_of CHEBI:33696 ! nucleic acid +intersection_of: has_primary_input CHEBI:33696 ! nucleic acid +relationship: has_primary_input CHEBI:33696 ! nucleic acid [Term] id: GO:0050658 @@ -74365,8 +107442,8 @@ def: "The directed movement of RNA, ribonucleic acids, into, out of or within a is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33697 ! ribonucleic acid -relationship: transports_or_maintains_localization_of CHEBI:33697 ! ribonucleic acid +intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid +relationship: has_primary_input CHEBI:33697 ! ribonucleic acid [Term] id: GO:0050666 @@ -74617,6 +107694,47 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006954 ! inflammatory response relationship: positively_regulates GO:0006954 ! inflammatory response +[Term] +id: GO:0050730 +name: regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +is_a: GO:0001932 ! regulation of protein phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation +relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050731 +name: positive regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050732 +name: negative regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + [Term] id: GO:0050764 name: regulation of phagocytosis @@ -74668,7 +107786,6 @@ is_a: GO:0051960 ! regulation of nervous system development is_a: GO:0060284 ! regulation of cell development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022008 ! neurogenesis -relationship: part_of GO:0048699 ! generation of neurons relationship: regulates GO:0022008 ! neurogenesis [Term] @@ -74896,6 +108013,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] synonym: "regulation of behaviour" EXACT [] is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007610 ! behavior relationship: regulates GO:0007610 ! behavior @@ -75092,6 +108210,27 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0050817 ! coagulation relationship: positively_regulates GO:0050817 ! coagulation +[Term] +id: GO:0050832 +name: defense response to fungus +namespace: biological_process +alt_id: GO:0009623 +alt_id: GO:0009817 +alt_id: GO:0042831 +def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to fungi" EXACT [] +synonym: "defence response to fungus" EXACT [] +synonym: "defense response to fungi" EXACT [] +synonym: "defense response to fungus, incompatible interaction" NARROW [] +synonym: "resistance response to pathogenic fungi" NARROW [] +synonym: "resistance response to pathogenic fungus" NARROW [] +synonym: "response to parasitic fungi" NARROW [] +synonym: "response to parasitic fungus" NARROW [] +is_a: GO:0006952 ! defense response +is_a: GO:0009620 ! response to fungus +intersection_of: GO:0006952 ! defense response +intersection_of: has_input NCBITaxon:4751 ! Fungi + [Term] id: GO:0050839 name: cell adhesion molecule binding @@ -75380,6 +108519,7 @@ subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir +subset: prokaryote_subset synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process @@ -76001,14 +109141,43 @@ intersection_of: positively_regulates GO:0004465 ! lipoprotein lipase activity relationship: positively_regulates GO:0004465 ! lipoprotein lipase activity [Term] -id: GO:0051027 -name: DNA transport +id: GO:0051017 +name: actin filament bundle assembly namespace: biological_process -def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] -is_a: GO:0050657 ! nucleic acid transport -intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:16991 ! deoxyribonucleic acid -relationship: transports_or_maintains_localization_of CHEBI:16991 ! deoxyribonucleic acid +alt_id: GO:0045011 +def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] +synonym: "actin bundling activity" RELATED [] +synonym: "actin cable assembly" RELATED [GOC:mah] +synonym: "actin cable formation" RELATED [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0061572 ! actin filament bundle organization +intersection_of: GO:0022607 ! cellular component assembly +intersection_of: results_in_assembly_of GO:0032432 ! actin filament bundle +relationship: results_in_assembly_of GO:0032432 ! actin filament bundle + +[Term] +id: GO:0051032 +name: nucleic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] +is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33696 ! nucleic acid +relationship: has_primary_input CHEBI:33696 ! nucleic acid +relationship: part_of GO:0050657 ! nucleic acid transport + +[Term] +id: GO:0051033 +name: RNA transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] +xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" +is_a: GO:0051032 ! nucleic acid transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid +relationship: has_primary_input CHEBI:33697 ! ribonucleic acid +relationship: part_of GO:0050658 ! RNA transport [Term] id: GO:0051046 @@ -76172,6 +109341,20 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input PR:000001753 ! transcription factor NF-kappa-B subunit relationship: has_input PR:000001753 ! transcription factor NF-kappa-B subunit +[Term] +id: GO:0051078 +name: meiotic nuclear membrane disassembly +namespace: biological_process +def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] +synonym: "meiotic nuclear envelope breakdown" RELATED [] +synonym: "meiotic nuclear envelope catabolism" RELATED [] +synonym: "meiotic nuclear envelope degradation" RELATED [] +synonym: "meiotic nuclear envelope disassembly" RELATED [] +is_a: GO:0051081 ! nuclear membrane disassembly +is_a: GO:1903046 ! meiotic cell cycle process +intersection_of: GO:0051081 ! nuclear membrane disassembly +intersection_of: part_of GO:0051321 ! meiotic cell cycle + [Term] id: GO:0051081 name: nuclear membrane disassembly @@ -76260,14 +109443,15 @@ intersection_of: negatively_regulates GO:0005488 ! binding relationship: negatively_regulates GO:0005488 ! binding [Term] -id: GO:0051101 -name: regulation of DNA binding -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] -is_a: GO:0051098 ! regulation of binding -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0003677 ! DNA binding -relationship: regulates GO:0003677 ! DNA binding +id: GO:0051119 +name: sugar transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "sugar/polyol channel activity" NARROW [] +xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose" +xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region" +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0051128 @@ -76759,12 +109943,20 @@ relationship: regulates GO:0019538 ! protein metabolic process id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process +alt_id: GO:0032270 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] +synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "activation of protein metabolic process" NARROW [] +synonym: "positive regulation of cellular protein metabolic process" EXACT [] +synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "positive regulation of protein metabolism" EXACT [] +synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "stimulation of protein metabolic process" NARROW [] +synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up regulation of protein metabolic process" EXACT [] +synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] +synonym: "upregulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process @@ -76772,16 +109964,24 @@ is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process +alt_id: GO:0032269 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] +synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down regulation of protein metabolic process" EXACT [] +synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] +synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] +synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "inhibition of protein metabolic process" NARROW [] +synonym: "negative regulation of cellular protein metabolic process" EXACT [] +synonym: "negative regulation of cellular protein metabolism" EXACT [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process @@ -76789,6 +109989,7 @@ is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23112 xsd:anyURI [Term] id: GO:0051249 @@ -76904,10 +110105,9 @@ is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0051270 name: regulation of cellular component movement -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] +def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [] synonym: "regulation of cell movement" RELATED [] -synonym: "regulation of cellular component motion" EXACT [GOC:mah] +synonym: "regulation of cellular component motion" EXACT [] is_a: GO:0032879 ! regulation of localization is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -76917,9 +110117,8 @@ relationship: regulates GO:0006928 ! movement of cell or subcellular component [Term] id: GO:0051271 name: negative regulation of cellular component movement -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] -synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [] +synonym: "negative regulation of cellular component motion" EXACT [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation @@ -76929,9 +110128,8 @@ relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular [Term] id: GO:0051272 name: positive regulation of cellular component movement -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] -synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] +def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [] +synonym: "positive regulation of cellular component motion" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation @@ -76942,6 +110140,7 @@ relationship: positively_regulates GO:0006928 ! movement of cell or subcellular id: GO:0051276 name: chromosome organization namespace: biological_process +alt_id: GO:0006323 alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] @@ -76950,12 +110149,16 @@ subset: goslim_drosophila subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] +synonym: "DNA condensation" EXACT [] +synonym: "DNA packaging" NARROW [] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005694 ! chromosome relationship: results_in_organization_of GO:0005694 ! chromosome +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22811 xsd:anyURI +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/4585 xsd:anyURI [Term] id: GO:0051285 @@ -77010,7 +110213,7 @@ is_a: GO:0050000 ! chromosome localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization -intersection_of: transports_or_maintains_localization_of GO:0005694 ! chromosome +intersection_of: has_primary_input GO:0005694 ! chromosome [Term] id: GO:0051304 @@ -77087,6 +110290,8 @@ is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140013 ! meiotic nuclear division relationship: has_part GO:0140013 ! meiotic nuclear division +relationship: in_taxon NCBITaxon:2759 ! Eukaryota +relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota [Term] id: GO:0051325 @@ -77372,16 +110577,16 @@ name: norepinephrine binding namespace: molecular_function def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] synonym: "noradrenaline binding" EXACT [] -is_a: GO:1901338 ! catecholamine binding +is_a: GO:0043169 ! cation binding intersection_of: GO:0005488 ! binding -intersection_of: has_input CHEBI:33569 ! noradrenaline -relationship: has_input CHEBI:33569 ! noradrenaline +intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_input CHEBI:72587 ! (R)-noradrenaline(1+) [Term] id: GO:0051402 name: neuron apoptotic process namespace: biological_process -def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663] +def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis] synonym: "apoptosis of neuronal cells" EXACT [] synonym: "apoptosis of neurons" EXACT [] synonym: "neuron apoptosis" NARROW [] @@ -77397,6 +110602,19 @@ is_a: GO:0070997 ! neuron death intersection_of: GO:0006915 ! apoptotic process intersection_of: occurs_in CL:0000540 ! neuron +[Term] +id: GO:0051410 +name: detoxification of nitrogen compound +namespace: biological_process +def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] +synonym: "detoxification of nitrogenous compound" EXACT [] +synonym: "nitric oxide (NO) detoxification" NARROW [] +is_a: GO:0098754 ! detoxification +intersection_of: GO:0098754 ! detoxification +intersection_of: has_input CHEBI:51143 ! nitrogen molecular entity +relationship: has_input CHEBI:51143 ! nitrogen molecular entity +relationship: part_of GO:1901698 ! response to nitrogen compound + [Term] id: GO:0051445 name: regulation of meiotic cell cycle @@ -77474,6 +110692,78 @@ intersection_of: GO:0016477 ! cell migration intersection_of: results_in_movement_of CL:0000056 ! myoblast relationship: results_in_movement_of CL:0000056 ! myoblast +[Term] +id: GO:0051458 +name: corticotropin secretion +def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [] +synonym: "ACTH secretion" EXACT [] +synonym: "adrenocorticotropic hormone secretion" EXACT [] +synonym: "adrenocorticotropin secretion" RELATED [] +synonym: "adrenotropic hormone secretion" EXACT [] +synonym: "adrenotropin secretion" EXACT [] +synonym: "corticotropic hormone secretion" EXACT [] +is_a: GO:0030072 ! peptide hormone secretion +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0051459 +name: regulation of corticotropin secretion +def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [] +synonym: "regulation of ACTH secretion" EXACT [] +synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [] +synonym: "regulation of adrenocorticotropin secretion" EXACT [] +synonym: "regulation of adrenotropin hormone secretion" EXACT [] +synonym: "regulation of adrenotropin secretion" EXACT [] +synonym: "regulation of corticotropic hormone secretion" EXACT [] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0090276 ! regulation of peptide hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051458 ! corticotropin secretion +relationship: regulates GO:0051458 ! corticotropin secretion + +[Term] +id: GO:0051460 +name: negative regulation of corticotropin secretion +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [] +synonym: "down regulation of adrenocorticotropin secretion" EXACT [] +synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] +synonym: "downregulation of adrenocorticotropin secretion" EXACT [] +synonym: "inhibition of adrenocorticotropin secretion" NARROW [] +synonym: "negative regulation of ACTH secretion" EXACT [] +synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] +synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] +synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] +synonym: "negative regulation of adrenotropin secretion" EXACT [] +synonym: "negative regulation of corticotropic hormone secretion" EXACT [] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0051459 ! regulation of corticotropin secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051458 ! corticotropin secretion +relationship: negatively_regulates GO:0051458 ! corticotropin secretion + +[Term] +id: GO:0051461 +name: positive regulation of corticotropin secretion +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [] +synonym: "activation of adrenocorticotropin secretion" NARROW [] +synonym: "positive regulation of ACTH secretion" EXACT [] +synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] +synonym: "positive regulation of adrenocorticotropin secretion" EXACT [] +synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] +synonym: "positive regulation of adrenotropin secretion" EXACT [] +synonym: "positive regulation of corticotropic hormone secretion" EXACT [] +synonym: "stimulation of adrenocorticotropin secretion" NARROW [] +synonym: "up regulation of adrenocorticotropin secretion" EXACT [] +synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] +synonym: "upregulation of adrenocorticotropin secretion" EXACT [] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0051459 ! regulation of corticotropin secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051458 ! corticotropin secretion +relationship: positively_regulates GO:0051458 ! corticotropin secretion + [Term] id: GO:0051465 name: negative regulation of corticotropin-releasing hormone secretion @@ -77750,6 +111040,21 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to electricity" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus +[Term] +id: GO:0051604 +name: protein maturation +namespace: biological_process +def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +subset: prokaryote_subset +is_a: GO:0019538 ! protein metabolic process +relationship: part_of GO:0010467 ! gene expression + [Term] id: GO:0051606 name: detection of stimulus @@ -77761,6 +111066,140 @@ synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus +[Term] +id: GO:0051608 +name: histamine transport +def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [] +is_a: GO:0006812 ! cation transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0051620 +name: norepinephrine uptake +namespace: biological_process +def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] +synonym: "levarterenol reuptake" EXACT [] +synonym: "levarterenol uptake" EXACT [] +synonym: "noradrenaline reuptake" EXACT [] +synonym: "noradrenaline uptake" EXACT [] +synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "norepinephrine reuptake" EXACT [] +is_a: GO:0015874 ! norepinephrine transport +is_a: GO:0090493 ! catecholamine uptake +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+) +intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure +intersection_of: has_target_start_location GO:0005576 ! extracellular region + +[Term] +id: GO:0051621 +name: regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] +synonym: "regulation of levarterenol uptake" EXACT [] +synonym: "regulation of noradrenaline uptake" EXACT [] +synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051620 ! norepinephrine uptake +relationship: regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051622 +name: negative regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "down regulation of norepinephrine uptake" EXACT [] +synonym: "down-regulation of norepinephrine uptake" EXACT [] +synonym: "downregulation of norepinephrine uptake" EXACT [] +synonym: "negative regulation of levarterenol uptake" EXACT [] +synonym: "negative regulation of noradrenaline uptake" EXACT [] +synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051621 ! regulation of norepinephrine uptake +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051620 ! norepinephrine uptake +relationship: negatively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051623 +name: positive regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "activation of norepinephrine uptake" NARROW [] +synonym: "positive regulation of levarterenol uptake" EXACT [] +synonym: "positive regulation of noradrenaline uptake" EXACT [] +synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of norepinephrine uptake" NARROW [] +synonym: "up regulation of norepinephrine uptake" EXACT [] +synonym: "up-regulation of norepinephrine uptake" EXACT [] +synonym: "upregulation of norepinephrine uptake" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051621 ! regulation of norepinephrine uptake +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051620 ! norepinephrine uptake +relationship: positively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051630 +name: acetylcholine uptake +namespace: biological_process +def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] +synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015870 ! acetylcholine transport +is_a: GO:0098657 ! import into cell +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:15355 ! acetylcholine +intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure +intersection_of: has_target_start_location GO:0005576 ! extracellular region + +[Term] +id: GO:0051631 +name: regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] +synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051952 ! regulation of amine transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051630 ! acetylcholine uptake +relationship: regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051632 +name: negative regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "down regulation of acetylcholine uptake" EXACT [] +synonym: "down-regulation of acetylcholine uptake" EXACT [] +synonym: "downregulation of acetylcholine uptake" EXACT [] +synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051953 ! negative regulation of amine transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake +relationship: negatively_regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051633 +name: positive regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "activation of acetylcholine uptake" NARROW [] +synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of acetylcholine uptake" NARROW [] +synonym: "up regulation of acetylcholine uptake" EXACT [] +synonym: "up-regulation of acetylcholine uptake" EXACT [] +synonym: "upregulation of acetylcholine uptake" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051954 ! positive regulation of amine transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake +relationship: positively_regulates GO:0051630 ! acetylcholine uptake + [Term] id: GO:0051640 name: organelle localization @@ -77771,10 +111210,11 @@ synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0043226 ! organelle +intersection_of: has_primary_input GO:0043226 ! organelle +relationship: has_primary_input GO:0043226 ! organelle relationship: in_taxon NCBITaxon:2759 ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota -relationship: transports_or_maintains_localization_of GO:0043226 ! organelle +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI [Term] id: GO:0051641 @@ -77806,8 +111246,8 @@ synonym: "Golgi body localization" EXACT [] synonym: "Golgi localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005794 ! Golgi apparatus -relationship: transports_or_maintains_localization_of GO:0005794 ! Golgi apparatus +intersection_of: has_primary_input GO:0005794 ! Golgi apparatus +relationship: has_primary_input GO:0005794 ! Golgi apparatus [Term] id: GO:0051647 @@ -77820,8 +111260,8 @@ synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005634 ! nucleus -relationship: transports_or_maintains_localization_of GO:0005634 ! nucleus +intersection_of: has_primary_input GO:0005634 ! nucleus +relationship: has_primary_input GO:0005634 ! nucleus [Term] id: GO:0051648 @@ -77833,8 +111273,8 @@ synonym: "establishment and maintenance of vesicle localization" EXACT [] synonym: "vesicle localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0031982 ! vesicle -relationship: transports_or_maintains_localization_of GO:0031982 ! vesicle +intersection_of: has_primary_input GO:0031982 ! vesicle +relationship: has_primary_input GO:0031982 ! vesicle [Term] id: GO:0051649 @@ -77859,13 +111299,12 @@ id: GO:0051650 name: establishment of vesicle localization namespace: biological_process def: "The directed movement of a vesicle to a specific location." [GOC:ai] -subset: goslim_aspergillus synonym: "establishment of vesicle localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization -intersection_of: transports_or_maintains_localization_of GO:0031982 ! vesicle +intersection_of: has_primary_input GO:0031982 ! vesicle [Term] id: GO:0051656 @@ -77876,7 +111315,7 @@ synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization -intersection_of: transports_or_maintains_localization_of GO:0043226 ! organelle +intersection_of: has_primary_input GO:0043226 ! organelle [Term] id: GO:0051668 @@ -77905,8 +111344,8 @@ synonym: "localisation of cell" EXACT [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0051179 ! localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of CL:0000000 ! cell -relationship: transports_or_maintains_localization_of CL:0000000 ! cell +intersection_of: has_primary_input CL:0000000 ! cell +relationship: has_primary_input CL:0000000 ! cell [Term] id: GO:0051683 @@ -77920,7 +111359,7 @@ is_a: GO:0051645 ! Golgi localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization -intersection_of: transports_or_maintains_localization_of GO:0005794 ! Golgi apparatus +intersection_of: has_primary_input GO:0005794 ! Golgi apparatus [Term] id: GO:0051699 @@ -78151,9 +111590,9 @@ def: "Any process in which a pigment granule is transported to, and/or maintaine synonym: "pigment granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0048770 ! pigment granule +intersection_of: has_primary_input GO:0048770 ! pigment granule +relationship: has_primary_input GO:0048770 ! pigment granule relationship: part_of GO:0033059 ! cellular pigmentation -relationship: transports_or_maintains_localization_of GO:0048770 ! pigment granule [Term] id: GO:0051884 @@ -78253,7 +111692,7 @@ is_a: GO:0006810 ! transport is_a: GO:0051875 ! pigment granule localization is_a: GO:0051905 ! establishment of pigment granule localization intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of GO:0048770 ! pigment granule +intersection_of: has_primary_input GO:0048770 ! pigment granule [Term] id: GO:0051905 @@ -78328,6 +111767,16 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007600 ! sensory perception relationship: regulates GO:0007600 ! sensory perception +[Term] +id: GO:0051932 +name: synaptic transmission, GABAergic +def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [] +synonym: "GABAergic synaptic transmission" EXACT [] +synonym: "synaptic transmission, GABA mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + [Term] id: GO:0051937 name: catecholamine transport @@ -78336,8 +111785,8 @@ def: "The directed movement of catecholamines, a group of physiologically import is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:33567 ! catecholamine -relationship: transports_or_maintains_localization_of CHEBI:33567 ! catecholamine +intersection_of: has_primary_input CHEBI:33567 ! catecholamine +relationship: has_primary_input CHEBI:33567 ! catecholamine [Term] id: GO:0051952 @@ -78992,6 +112441,17 @@ intersection_of: has_input CL:0000031 ! neuroblast (sensu Vertebrata) relationship: has_input CL:0000031 ! neuroblast (sensu Vertebrata) relationship: part_of GO:0007405 ! neuroblast proliferation +[Term] +id: GO:0055059 +name: asymmetric neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0045165 ! cell fate commitment +is_a: GO:0055057 ! neuroblast division +intersection_of: GO:0008356 ! asymmetric cell division +intersection_of: has_input CL:0000031 ! neuroblast (sensu Vertebrata) + [Term] id: GO:0055062 name: phosphate ion homeostasis @@ -79029,6 +112489,7 @@ namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] subset: goslim_generic subset: goslim_pombe +subset: prokaryote_subset is_a: GO:0055080 ! cation homeostasis is_a: GO:0098771 ! inorganic ion homeostasis intersection_of: GO:0048878 ! chemical homeostasis @@ -79085,6 +112546,17 @@ intersection_of: GO:0048878 ! chemical homeostasis intersection_of: regulates_levels_of CHEBI:33515 ! transition element cation relationship: regulates_levels_of CHEBI:33515 ! transition element cation +[Term] +id: GO:0055078 +name: sodium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis +intersection_of: GO:0048878 ! chemical homeostasis +intersection_of: regulates_levels_of CHEBI:29101 ! sodium(1+) +relationship: regulates_levels_of CHEBI:29101 ! sodium(1+) + [Term] id: GO:0055080 name: cation homeostasis @@ -79142,6 +112614,9 @@ synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] synonym: "membrane transport" EXACT [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process +intersection_of: GO:0006810 ! transport +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: results_in_transport_across GO:0016020 ! membrane created_by: tb creation_date: 2015-10-21T13:22:47Z @@ -79154,6 +112629,7 @@ subset: goslim_drosophila subset: goslim_generic subset: goslim_pombe subset: goslim_yeast +subset: prokaryote_subset synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process @@ -79276,6 +112752,12 @@ def: "An automatic response to a stimulus beginning with a nerve impulse from a xref: Wikipedia:Reflex is_a: GO:0009605 ! response to external stimulus +[Term] +id: GO:0060005 +name: vestibular reflex +def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [] +is_a: GO:0060004 ! reflex + [Term] id: GO:0060008 name: Sertoli cell differentiation @@ -79534,6 +113016,22 @@ def: "The reproductive developmental process whose specific outcome is the progr synonym: "Mullerian tract development" RELATED [] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0000995 ! uterus +relationship: results_in_development_of UBERON:0000995 ! uterus + +[Term] +id: GO:0060066 +name: oviduct development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube development" NARROW [GOC:bf] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0035295 ! tube development +is_a: GO:0048608 ! reproductive structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003889 ! fallopian tube +relationship: results_in_development_of UBERON:0003889 ! fallopian tube [Term] id: GO:0060068 @@ -79592,6 +113090,13 @@ synonym: "regulation of excitatory post-synaptic membrane potential" EXACT [] is_a: GO:0060078 ! regulation of postsynaptic membrane potential relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic +[Term] +id: GO:0060082 +name: eye blink reflex +def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [] +synonym: "nictitating membrane reflex" EXACT [] +is_a: GO:0060004 ! reflex + [Term] id: GO:0060083 name: smooth muscle contraction involved in micturition @@ -79623,6 +113128,7 @@ def: "A compound molecular function in which an effector function is controlled subset: gocheck_do_not_manually_annotate subset: goslim_generic subset: goslim_pir +subset: prokaryote_subset is_a: GO:0003674 ! molecular_function [Term] @@ -79804,6 +113310,9 @@ synonym: "limb bud development" NARROW [GOC:dph] synonym: "paired limb/fin development" EXACT [] xref: Wikipedia:Limb_development is_a: GO:0048736 ! appendage development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0004708 ! paired limb/fin +relationship: results_in_development_of UBERON:0004708 ! paired limb/fin [Term] id: GO:0060185 @@ -80126,6 +113635,40 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030728 ! ovulation relationship: negatively_regulates GO:0030728 ! ovulation +[Term] +id: GO:0060281 +name: regulation of oocyte development +namespace: biological_process +def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] +is_a: GO:1905879 ! regulation of oogenesis +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0048599 ! oocyte development +relationship: regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060282 +name: positive regulation of oocyte development +namespace: biological_process +def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:2000243 ! positive regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0048599 ! oocyte development +relationship: positively_regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060283 +name: negative regulation of oocyte development +namespace: biological_process +def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:2000242 ! negative regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0048599 ! oocyte development +relationship: negatively_regulates GO:0048599 ! oocyte development + [Term] id: GO:0060284 name: regulation of cell development @@ -80342,7 +113885,7 @@ name: bone development namespace: biological_process def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] is_a: GO:0048513 ! animal organ development -intersection_of: GO:0048856 ! anatomical structure development +intersection_of: GO:0048513 ! animal organ development intersection_of: results_in_development_of UBERON:0001474 ! bone element relationship: part_of GO:0001501 ! skeletal system development relationship: results_in_development_of UBERON:0001474 ! bone element @@ -80402,6 +113945,53 @@ intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0003685 ! cranial suture relationship: results_in_morphogenesis_of UBERON:0003685 ! cranial suture +[Term] +id: GO:0060374 +name: mast cell differentiation +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0060375 +name: regulation of mast cell differentiation +def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0060374 ! mast cell differentiation +relationship: regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060376 +name: positive regulation of mast cell differentiation +def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0060375 ! regulation of mast cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0060374 ! mast cell differentiation +relationship: positively_regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060377 +name: negative regulation of mast cell differentiation +def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0060375 ! regulation of mast cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0060374 ! mast cell differentiation +relationship: negatively_regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060378 +name: regulation of brood size +namespace: biological_process +def: "Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb] +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048609 ! multicellular organismal reproductive process +is_a: GO:0065007 ! biological regulation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates_characteristic PATO:0000276 ! brood size +relationship: regulates_characteristic PATO:0000276 ! brood size + [Term] id: GO:0060379 name: cardiac muscle cell myoblast differentiation @@ -80593,7 +114183,7 @@ name: heart growth namespace: biological_process def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] is_a: GO:0035265 ! organ growth -intersection_of: GO:0040007 ! growth +intersection_of: GO:0048589 ! developmental growth intersection_of: results_in_growth_of UBERON:0000948 ! heart relationship: part_of GO:0007507 ! heart development relationship: results_in_growth_of UBERON:0000948 ! heart @@ -80692,13 +114282,58 @@ intersection_of: GO:0048646 ! anatomical structure formation involved in morphog intersection_of: results_in_formation_of UBERON:0002048 ! lung relationship: results_in_formation_of UBERON:0002048 ! lung +[Term] +id: GO:0060433 +name: bronchus development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0030323 ! respiratory tube development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002185 ! bronchus +relationship: part_of GO:0060541 ! respiratory system development +relationship: results_in_development_of UBERON:0002185 ! bronchus + +[Term] +id: GO:0060434 +name: bronchus morphogenesis +namespace: biological_process +def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0035239 ! tube morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0002185 ! bronchus +relationship: part_of GO:0060433 ! bronchus development +relationship: results_in_morphogenesis_of UBERON:0002185 ! bronchus + +[Term] +id: GO:0060435 +name: bronchiole development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung] +is_a: GO:0030323 ! respiratory tube development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002186 ! bronchiole +relationship: part_of GO:0030324 ! lung development +relationship: results_in_development_of UBERON:0002186 ! bronchiole + +[Term] +id: GO:0060436 +name: bronchiole morphogenesis +namespace: biological_process +def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph] +is_a: GO:0035239 ! tube morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0002186 ! bronchiole +relationship: part_of GO:0060435 ! bronchiole development +relationship: results_in_morphogenesis_of UBERON:0002186 ! bronchiole + [Term] id: GO:0060437 name: lung growth namespace: biological_process def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] is_a: GO:0035265 ! organ growth -intersection_of: GO:0040007 ! growth +intersection_of: GO:0048589 ! developmental growth intersection_of: results_in_growth_of UBERON:0002048 ! lung relationship: part_of GO:0030324 ! lung development relationship: results_in_growth_of UBERON:0002048 ! lung @@ -80766,6 +114401,30 @@ intersection_of: GO:0061138 ! morphogenesis of a branching epithelium intersection_of: part_of GO:0060603 ! mammary gland duct morphogenesis relationship: part_of GO:0060603 ! mammary gland duct morphogenesis +[Term] +id: GO:0060450 +name: positive regulation of hindgut contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] +is_a: GO:0043134 ! regulation of hindgut contraction +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +is_a: GO:0060456 ! positive regulation of digestive system process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0043133 ! hindgut contraction +relationship: positively_regulates GO:0043133 ! hindgut contraction + +[Term] +id: GO:0060451 +name: negative regulation of hindgut contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] +is_a: GO:0043134 ! regulation of hindgut contraction +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +is_a: GO:0060457 ! negative regulation of digestive system process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0043133 ! hindgut contraction +relationship: negatively_regulates GO:0043133 ! hindgut contraction + [Term] id: GO:0060452 name: positive regulation of cardiac muscle contraction @@ -80927,6 +114586,19 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009566 ! fertilization relationship: negatively_regulates GO:0009566 ! fertilization +[Term] +id: GO:0060468 +name: prevention of polyspermy +namespace: biological_process +def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] +synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] +synonym: "polyspermy block" EXACT [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0060467 ! negative regulation of fertilization +intersection_of: GO:0060467 ! negative regulation of fertilization +intersection_of: part_of GO:0007343 ! egg activation +relationship: part_of GO:0007343 ! egg activation + [Term] id: GO:0060474 name: positive regulation of flagellated sperm motility involved in capacitation @@ -80945,9 +114617,9 @@ name: protein localization involved in acrosome reaction namespace: biological_process def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph] synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah] +is_a: GO:0008104 ! protein localization is_a: GO:0022414 ! reproductive process is_a: GO:0030029 ! actin filament-based process -is_a: GO:0034613 ! cellular protein localization intersection_of: GO:0008104 ! protein localization intersection_of: part_of GO:0007340 ! acrosome reaction relationship: part_of GO:0007340 ! acrosome reaction @@ -80973,6 +114645,17 @@ intersection_of: results_in_development_of UBERON:0003104 ! mesenchyme relationship: part_of GO:0048513 ! animal organ development relationship: results_in_development_of UBERON:0003104 ! mesenchyme +[Term] +id: GO:0060486 +name: club cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung, PMID:28144783] +synonym: "Clara cell differentiation" EXACT [PMID:28144783] +is_a: GO:0060487 ! lung epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000158 ! club cell +relationship: results_in_acquisition_of_features_of CL:0000158 ! club cell + [Term] id: GO:0060487 name: lung epithelial cell differentiation @@ -81031,6 +114714,61 @@ intersection_of: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060425 ! lung morphogenesis relationship: part_of GO:0060428 ! lung epithelium development +[Term] +id: GO:0060532 +name: bronchus cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary cartilage development" EXACT [] +is_a: GO:0051216 ! cartilage development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001956 ! cartilage of bronchus +relationship: part_of GO:0060433 ! bronchus development +relationship: results_in_development_of UBERON:0001956 ! cartilage of bronchus +created_by: dph +creation_date: 2009-04-10T08:12:06Z + +[Term] +id: GO:0060533 +name: bronchus cartilage morphogenesis +namespace: biological_process +def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0060536 ! cartilage morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0001956 ! cartilage of bronchus +relationship: part_of GO:0060434 ! bronchus morphogenesis +relationship: part_of GO:0060532 ! bronchus cartilage development +relationship: results_in_morphogenesis_of UBERON:0001956 ! cartilage of bronchus +created_by: dph +creation_date: 2009-04-10T08:47:41Z + +[Term] +id: GO:0060534 +name: trachea cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] +is_a: GO:0051216 ! cartilage development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003604 ! trachea cartilage +relationship: part_of GO:0060438 ! trachea development +relationship: results_in_development_of UBERON:0003604 ! trachea cartilage +created_by: dph +creation_date: 2009-04-10T09:00:18Z + +[Term] +id: GO:0060535 +name: trachea cartilage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] +is_a: GO:0060536 ! cartilage morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0003604 ! trachea cartilage +relationship: part_of GO:0060439 ! trachea morphogenesis +relationship: part_of GO:0060534 ! trachea cartilage development +relationship: results_in_morphogenesis_of UBERON:0003604 ! trachea cartilage +created_by: dph +creation_date: 2009-04-10T09:07:48Z + [Term] id: GO:0060536 name: cartilage morphogenesis @@ -81227,6 +114965,45 @@ relationship: part_of GO:0060581 ! cell fate commitment involved in pattern spec created_by: dph creation_date: 2009-05-05T02:19:14Z +[Term] +id: GO:0060574 +name: intestinal epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] +is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0002563 ! intestinal epithelial cell +relationship: part_of GO:0060576 ! intestinal epithelial cell development +relationship: results_in_maturation_of CL:0002563 ! intestinal epithelial cell +created_by: dph +creation_date: 2009-05-06T08:10:41Z + +[Term] +id: GO:0060575 +name: intestinal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0002563 ! intestinal epithelial cell +relationship: part_of GO:0048565 ! digestive tract development +relationship: results_in_acquisition_of_features_of CL:0002563 ! intestinal epithelial cell +created_by: dph +creation_date: 2009-05-06T08:17:56Z + +[Term] +id: GO:0060576 +name: intestinal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0002066 ! columnar/cuboidal epithelial cell development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of CL:0002563 ! intestinal epithelial cell +relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation +relationship: results_in_development_of CL:0002563 ! intestinal epithelial cell +created_by: dph +creation_date: 2009-05-06T08:20:24Z + [Term] id: GO:0060577 name: pulmonary vein morphogenesis @@ -81240,6 +115017,18 @@ relationship: results_in_morphogenesis_of UBERON:0002016 ! pulmonary vein created_by: dph creation_date: 2009-05-06T08:44:04Z +[Term] +id: GO:0060578 +name: superior vena cava morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] +is_a: GO:0048845 ! venous blood vessel morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0001585 ! anterior vena cava +relationship: results_in_morphogenesis_of UBERON:0001585 ! anterior vena cava +created_by: dph +creation_date: 2009-05-06T08:47:21Z + [Term] id: GO:0060581 name: cell fate commitment involved in pattern specification @@ -81404,6 +115193,7 @@ name: nipple morphogenesis namespace: biological_process def: "The process in which the nipple is generated and organized." [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060443 ! mammary gland morphogenesis relationship: part_of GO:0060618 ! nipple development created_by: dph creation_date: 2009-05-29T10:45:44Z @@ -81430,6 +115220,32 @@ relationship: part_of GO:0060658 ! nipple morphogenesis created_by: dph creation_date: 2009-05-29T11:04:04Z +[Term] +id: GO:0060669 +name: embryonic placenta morphogenesis +namespace: biological_process +def: "The process in which the embryonic placenta is generated and organized." [GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0007106 ! chorionic villus +relationship: part_of GO:0001892 ! embryonic placenta development +relationship: results_in_morphogenesis_of UBERON:0007106 ! chorionic villus +created_by: dph +creation_date: 2009-06-02T09:33:37Z + +[Term] +id: GO:0060670 +name: branching involved in labyrinthine layer morphogenesis +namespace: biological_process +def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0061138 ! morphogenesis of a branching epithelium +intersection_of: GO:0061138 ! morphogenesis of a branching epithelium +intersection_of: part_of GO:0060713 ! labyrinthine layer morphogenesis +relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis +created_by: dph +creation_date: 2009-06-02T10:40:40Z + [Term] id: GO:0060671 name: epithelial cell differentiation involved in embryonic placenta development @@ -81450,13 +115266,22 @@ namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377] synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling -is_a: GO:0022414 ! reproductive process intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0001890 ! placenta development relationship: part_of GO:0001892 ! embryonic placenta development created_by: dph creation_date: 2009-06-02T12:58:03Z +[Term] +id: GO:0060674 +name: placenta blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377] +is_a: GO:0001568 ! blood vessel development +relationship: part_of GO:0001890 ! placenta development +created_by: dph +creation_date: 2009-06-02T01:09:43Z + [Term] id: GO:0060675 name: ureteric bud morphogenesis @@ -81508,18 +115333,99 @@ id: GO:0060711 name: labyrinthine layer development namespace: biological_process def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph] -is_a: GO:0048608 ! reproductive structure development +is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003946 ! placenta labyrinth relationship: part_of GO:0001892 ! embryonic placenta development +relationship: results_in_development_of UBERON:0003946 ! placenta labyrinth created_by: dph creation_date: 2009-06-09T03:27:43Z +[Term] +id: GO:0060713 +name: labyrinthine layer morphogenesis +namespace: biological_process +def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0003946 ! placenta labyrinth +relationship: part_of GO:0060669 ! embryonic placenta morphogenesis +relationship: part_of GO:0060711 ! labyrinthine layer development +relationship: results_in_morphogenesis_of UBERON:0003946 ! placenta labyrinth +created_by: dph +creation_date: 2009-06-10T08:10:19Z + +[Term] +id: GO:0060714 +name: labyrinthine layer formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: results_in_formation_of UBERON:0003946 ! placenta labyrinth +relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis +relationship: results_in_formation_of UBERON:0003946 ! placenta labyrinth +created_by: dph +creation_date: 2009-06-10T08:13:14Z + +[Term] +id: GO:0060716 +name: labyrinthine layer blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph] +is_a: GO:0048568 ! embryonic organ development +is_a: GO:0060674 ! placenta blood vessel development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0004183 ! placental labyrinth blood vessel +relationship: part_of GO:0060711 ! labyrinthine layer development +relationship: results_in_development_of UBERON:0004183 ! placental labyrinth blood vessel +created_by: dph +creation_date: 2009-06-11T09:04:38Z + +[Term] +id: GO:0060717 +name: chorion development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph] +is_a: GO:1903867 ! extraembryonic membrane development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003124 ! chorion membrane +relationship: results_in_development_of UBERON:0003124 ! chorion membrane +created_by: dph +creation_date: 2009-06-11T02:37:50Z + +[Term] +id: GO:0060718 +name: chorionic trophoblast cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341] +is_a: GO:0030154 ! cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0011101 ! chorionic trophoblast cell +relationship: part_of GO:0060717 ! chorion development +relationship: results_in_acquisition_of_features_of CL:0011101 ! chorionic trophoblast cell +created_by: dph +creation_date: 2009-06-11T02:48:27Z + +[Term] +id: GO:0060719 +name: chorionic trophoblast cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph] +is_a: GO:0048468 ! cell development +intersection_of: GO:0048468 ! cell development +intersection_of: results_in_development_of CL:0011101 ! chorionic trophoblast cell +relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation +relationship: results_in_development_of CL:0011101 ! chorionic trophoblast cell +created_by: dph +creation_date: 2009-06-11T02:58:45Z + [Term] id: GO:0060722 name: cell proliferation involved in embryonic placenta development namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph] is_a: GO:0008283 ! cell population proliferation -is_a: GO:0022414 ! reproductive process intersection_of: GO:0008283 ! cell population proliferation intersection_of: part_of GO:0001892 ! embryonic placenta development relationship: part_of GO:0001892 ! embryonic placenta development @@ -81532,7 +115438,6 @@ name: regulation of cell proliferation involved in embryonic placenta developmen namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation -is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development @@ -82407,6 +116312,17 @@ relationship: part_of GO:0060993 ! kidney morphogenesis created_by: dph creation_date: 2010-01-21T11:25:23Z +[Term] +id: GO:0061007 +name: hepaticobiliary system process +namespace: biological_process +def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] +subset: goslim_generic +synonym: "hepatobiliary system process" EXACT [GOC:dph] +is_a: GO:0003008 ! system process +created_by: dph +creation_date: 2010-01-22T09:09:10Z + [Term] id: GO:0061008 name: hepaticobiliary system development @@ -82414,6 +116330,9 @@ namespace: biological_process def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] synonym: "hepatobiliary system development" EXACT [GOC:dph] is_a: GO:0048731 ! system development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002423 ! hepatobiliary system +relationship: results_in_development_of UBERON:0002423 ! hepatobiliary system created_by: dph creation_date: 2010-01-22T09:11:59Z @@ -82427,10 +116346,52 @@ synonym: "CBD development" EXACT [PMID:20614624] synonym: "EHBD development" BROAD [PMID:20614624] synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] is_a: GO:0035295 ! tube development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002394 ! bile duct relationship: part_of GO:0061008 ! hepaticobiliary system development +relationship: results_in_development_of UBERON:0002394 ! bile duct created_by: dph creation_date: 2010-01-22T09:17:13Z +[Term] +id: GO:0061010 +name: gall bladder development +namespace: biological_process +def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOC:dph] +is_a: GO:0048513 ! animal organ development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002110 ! gall bladder +relationship: part_of GO:0061008 ! hepaticobiliary system development +relationship: results_in_development_of UBERON:0002110 ! gall bladder +created_by: dph +creation_date: 2010-01-22T09:38:44Z + +[Term] +id: GO:0061011 +name: hepatic duct development +namespace: biological_process +def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] +is_a: GO:0061009 ! common bile duct development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001175 ! common hepatic duct +relationship: results_in_development_of UBERON:0001175 ! common hepatic duct +created_by: dph +creation_date: 2010-01-22T09:44:39Z + +[Term] +id: GO:0061017 +name: hepatoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0048863 ! stem cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:1000488 ! cholangiocyte +relationship: part_of GO:0001889 ! liver development +relationship: results_in_acquisition_of_features_of CL:1000488 ! cholangiocyte +created_by: dph +creation_date: 2010-02-02T09:08:03Z + [Term] id: GO:0061024 name: membrane organization @@ -82443,6 +116404,7 @@ subset: goslim_drosophila subset: goslim_generic subset: goslim_pir subset: goslim_pombe +subset: prokaryote_subset synonym: "cellular membrane organisation" EXACT [] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] @@ -82536,6 +116498,20 @@ relationship: negatively_regulates GO:0051216 ! cartilage development created_by: dph creation_date: 2010-02-09T03:41:35Z +[Term] +id: GO:0061038 +name: uterus morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0000995 ! uterus +relationship: part_of GO:0060065 ! uterus development +relationship: results_in_morphogenesis_of UBERON:0000995 ! uterus +created_by: dph +creation_date: 2010-02-22T11:12:35Z + [Term] id: GO:0061040 name: female gonad morphogenesis @@ -82846,6 +116822,47 @@ is_a: GO:0002367 ! cytokine production involved in immune response created_by: dph creation_date: 2010-04-13T11:29:42Z +[Term] +id: GO:0061097 +name: regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0045859 ! regulation of protein kinase activity +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0004713 ! protein tyrosine kinase activity +relationship: regulates GO:0004713 ! protein tyrosine kinase activity +created_by: dph +creation_date: 2010-04-26T02:34:53Z + +[Term] +id: GO:0061098 +name: positive regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0004713 ! protein tyrosine kinase activity +relationship: positively_regulates GO:0004713 ! protein tyrosine kinase activity +created_by: dph +creation_date: 2010-04-26T02:34:53Z + +[Term] +id: GO:0061099 +name: negative regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0004713 ! protein tyrosine kinase activity +relationship: negatively_regulates GO:0004713 ! protein tyrosine kinase activity +created_by: dph +creation_date: 2010-04-26T02:34:53Z + [Term] id: GO:0061100 name: lung neuroendocrine cell differentiation @@ -82910,6 +116927,31 @@ relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell diff created_by: dph creation_date: 2010-04-29T12:23:05Z +[Term] +id: GO:0061113 +name: pancreas morphogenesis +namespace: biological_process +def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0001264 ! pancreas +relationship: part_of GO:0031016 ! pancreas development +relationship: results_in_morphogenesis_of UBERON:0001264 ! pancreas +created_by: dph +creation_date: 2010-05-05T11:55:30Z + +[Term] +id: GO:0061114 +name: branching involved in pancreas morphogenesis +namespace: biological_process +def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] +is_a: GO:0061138 ! morphogenesis of a branching epithelium +intersection_of: GO:0061138 ! morphogenesis of a branching epithelium +intersection_of: part_of GO:0061113 ! pancreas morphogenesis +relationship: part_of GO:0061113 ! pancreas morphogenesis +created_by: dph +creation_date: 2010-05-05T12:03:04Z + [Term] id: GO:0061116 name: ductus venosus closure @@ -82932,6 +116974,20 @@ relationship: negatively_regulates GO:0060419 ! heart growth created_by: dph creation_date: 2010-05-17T07:31:28Z +[Term] +id: GO:0061130 +name: pancreatic bud formation +namespace: biological_process +def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] +is_a: GO:0048645 ! animal organ formation +is_a: GO:0061114 ! branching involved in pancreas morphogenesis +is_a: GO:0072175 ! epithelial tube formation +intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: results_in_formation_of UBERON:0003922 ! pancreatic epithelial bud +relationship: results_in_formation_of UBERON:0003922 ! pancreatic epithelial bud +created_by: dph +creation_date: 2010-05-17T09:33:40Z + [Term] id: GO:0061138 name: morphogenesis of a branching epithelium @@ -82992,6 +117048,32 @@ relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2010-06-03T09:18:02Z +[Term] +id: GO:0061152 +name: trachea submucosa development +namespace: biological_process +def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002202 ! submucosa of trachea +relationship: part_of GO:0060438 ! trachea development +relationship: results_in_development_of UBERON:0002202 ! submucosa of trachea +created_by: dph +creation_date: 2010-06-07T09:58:40Z + +[Term] +id: GO:0061153 +name: trachea gland development +namespace: biological_process +def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] +is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0005203 ! trachea gland +relationship: part_of GO:0061152 ! trachea submucosa development +relationship: results_in_development_of UBERON:0005203 ! trachea gland +created_by: dph +creation_date: 2010-06-07T10:10:51Z + [Term] id: GO:0061154 name: endothelial tube morphogenesis @@ -83030,6 +117112,35 @@ relationship: results_in_morphogenesis_of UBERON:0002012 ! pulmonary artery created_by: dph creation_date: 2010-06-15T09:13:47Z +[Term] +id: GO:0061178 +name: regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] +synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] +is_a: GO:0050796 ! regulation of insulin secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +created_by: dph +creation_date: 2010-07-13T09:38:42Z + +[Term] +id: GO:0061179 +name: negative regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] +synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph] +synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] +is_a: GO:0046676 ! negative regulation of insulin secretion +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +created_by: dph +creation_date: 2010-07-13T09:41:46Z + [Term] id: GO:0061180 name: mammary gland epithelium development @@ -83171,6 +117282,20 @@ relationship: results_in_formation_of UBERON:0001727 ! taste bud created_by: dph creation_date: 2010-07-27T12:22:26Z +[Term] +id: GO:0061205 +name: paramesonephric duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf] +synonym: "Mullerian duct development" EXACT [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0035295 ! tube development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0003890 ! Mullerian duct +relationship: results_in_development_of UBERON:0003890 ! Mullerian duct +created_by: dph +creation_date: 2010-07-30T10:54:47Z + [Term] id: GO:0061208 name: cell differentiation involved in mesonephros development @@ -83354,7 +117479,7 @@ creation_date: 2010-09-23T09:08:37Z id: GO:0061311 name: cell surface receptor signaling pathway involved in heart development namespace: biological_process -def: "Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] +def: "The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway @@ -83510,6 +117635,48 @@ relationship: results_in_development_of UBERON:0002384 ! connective tissue created_by: dph creation_date: 2012-03-22T12:53:41Z +[Term] +id: GO:0061450 +name: trophoblast cell migration +namespace: biological_process +def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph] +is_a: GO:0001667 ! ameboidal-type cell migration +is_a: GO:0022414 ! reproductive process +intersection_of: GO:0016477 ! cell migration +intersection_of: results_in_movement_of CL:0000351 ! trophoblast cell +relationship: part_of GO:0007566 ! embryo implantation +relationship: results_in_movement_of CL:0000351 ! trophoblast cell +created_by: dph +creation_date: 2012-07-10T08:38:37Z + +[Term] +id: GO:0061453 +name: interstitial cell of Cajal differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph] +synonym: "ICC differentiation" RELATED [GOC:dph] +is_a: GO:0060563 ! neuroepithelial cell differentiation +is_a: GO:0060575 ! intestinal epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0002088 ! interstitial cell of Cajal +relationship: results_in_acquisition_of_features_of CL:0002088 ! interstitial cell of Cajal +created_by: dph +creation_date: 2012-07-20T08:20:50Z + +[Term] +id: GO:0061455 +name: integral component of muscle cell projection membrane +namespace: cellular_component +def: "The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:dph, GOC:tb] +synonym: "integral to muscle cell projection membrane" EXACT [] +is_a: CARO:0000000 ! anatomical entity +is_a: GO:0005887 ! integral component of plasma membrane +intersection_of: GO:0016021 ! integral component of membrane +intersection_of: part_of GO:0036195 ! muscle cell projection membrane +relationship: part_of GO:0036195 ! muscle cell projection membrane +created_by: dph +creation_date: 2012-07-27T02:38:01Z + [Term] id: GO:0061458 name: reproductive system development @@ -83628,6 +117795,18 @@ relationship: results_in_disassembly_of GO:0005929 ! cilium created_by: dph creation_date: 2013-04-18T14:59:59Z +[Term] +id: GO:0061525 +name: hindgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph] +is_a: GO:0048565 ! digestive tract development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0001046 ! hindgut +relationship: results_in_development_of UBERON:0001046 ! hindgut +created_by: dph +creation_date: 2013-06-14T11:22:21Z + [Term] id: GO:0061526 name: acetylcholine secretion @@ -83636,10 +117815,18 @@ def: "The regulated release of acetylcholine by a cell." [GOC:dph] is_a: GO:0015870 ! acetylcholine transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:15355 ! acetylcholine +intersection_of: has_primary_input CHEBI:15355 ! acetylcholine created_by: dph creation_date: 2013-06-21T15:40:39Z +[Term] +id: GO:0061534 +name: gamma-aminobutyric acid secretion, neurotransmission +def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0014051 ! gamma-aminobutyric acid secretion +relationship: part_of GO:0051932 ! synaptic transmission, GABAergic + [Term] id: GO:0061535 name: glutamate secretion, neurotransmission @@ -83723,6 +117910,20 @@ relationship: results_in_morphogenesis_of UBERON:0000045 ! ganglion created_by: dph creation_date: 2013-07-10T08:44:57Z +[Term] +id: GO:0061553 +name: ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] +synonym: "ganglia maturation" RELATED [GOC:dph] +is_a: GO:0048799 ! animal organ maturation +intersection_of: GO:0071695 ! anatomical structure maturation +intersection_of: results_in_maturation_of UBERON:0000045 ! ganglion +relationship: part_of GO:0061548 ! ganglion development +relationship: results_in_maturation_of UBERON:0000045 ! ganglion +created_by: dph +creation_date: 2013-07-10T08:45:59Z + [Term] id: GO:0061554 name: ganglion formation @@ -83752,6 +117953,36 @@ relationship: results_in_morphogenesis_of UBERON:0001675 ! trigeminal ganglion created_by: dph creation_date: 2013-07-10T08:57:12Z +[Term] +id: GO:0061557 +name: trigeminal ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] +synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] +is_a: GO:0061558 ! cranial ganglion maturation +intersection_of: GO:0071695 ! anatomical structure maturation +intersection_of: results_in_maturation_of UBERON:0001675 ! trigeminal ganglion +relationship: part_of GO:0021635 ! trigeminal nerve maturation +relationship: part_of GO:0061551 ! trigeminal ganglion development +relationship: results_in_maturation_of UBERON:0001675 ! trigeminal ganglion +created_by: dph +creation_date: 2013-07-10T08:58:24Z + +[Term] +id: GO:0061558 +name: cranial ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] +synonym: "cranial ganglia maturation" RELATED [GOC:dph] +is_a: GO:0061553 ! ganglion maturation +intersection_of: GO:0071695 ! anatomical structure maturation +intersection_of: results_in_maturation_of UBERON:0001714 ! cranial ganglion +relationship: part_of GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0061550 ! cranial ganglion development +relationship: results_in_maturation_of UBERON:0001714 ! cranial ganglion +created_by: dph +creation_date: 2013-07-10T08:59:52Z + [Term] id: GO:0061559 name: cranial ganglion morphogenesis @@ -83804,6 +118035,31 @@ is_a: GO:0031175 ! neuron projection development created_by: dph creation_date: 2013-07-18T14:43:01Z +[Term] +id: GO:0061572 +name: actin filament bundle organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] +synonym: "actin filament cable organization" RELATED [GOC:dph] +is_a: GO:0007015 ! actin filament organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0032432 ! actin filament bundle +relationship: results_in_organization_of GO:0032432 ! actin filament bundle +created_by: dph +creation_date: 2013-08-02T11:24:11Z + +[Term] +id: GO:0061580 +name: colon epithelial cell migration +namespace: biological_process +def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] +is_a: GO:0061582 ! intestinal epithelial cell migration +intersection_of: GO:0016477 ! cell migration +intersection_of: results_in_movement_of CL:0011108 ! colon epithelial cell +relationship: results_in_movement_of CL:0011108 ! colon epithelial cell +created_by: dph +creation_date: 2013-12-23T07:26:54Z + [Term] id: GO:0061581 name: corneal epithelial cell migration @@ -83816,6 +118072,18 @@ relationship: results_in_movement_of CL:0000575 ! corneal epithelial cell created_by: dph creation_date: 2013-12-23T07:28:29Z +[Term] +id: GO:0061582 +name: intestinal epithelial cell migration +namespace: biological_process +def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] +is_a: GO:0010631 ! epithelial cell migration +intersection_of: GO:0016477 ! cell migration +intersection_of: results_in_movement_of CL:0002563 ! intestinal epithelial cell +relationship: results_in_movement_of CL:0002563 ! intestinal epithelial cell +created_by: dph +creation_date: 2013-12-23T07:30:55Z + [Term] id: GO:0061626 name: pharyngeal arch artery morphogenesis @@ -83848,6 +118116,18 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/1 created_by: dph creation_date: 2014-05-15T09:12:24Z +[Term] +id: GO:0061687 +name: detoxification of inorganic compound +namespace: biological_process +def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw] +is_a: GO:0098754 ! detoxification +intersection_of: GO:0098754 ! detoxification +intersection_of: has_input CHEBI:24835 ! inorganic molecular entity +relationship: has_input CHEBI:24835 ! inorganic molecular entity +created_by: dph +creation_date: 2015-03-09T09:16:23Z + [Term] id: GO:0061695 name: transferase complex, transferring phosphorus-containing groups @@ -83879,6 +118159,19 @@ is_a: GO:0007159 ! leukocyte cell-cell adhesion created_by: dph creation_date: 2016-02-29T16:42:11Z +[Term] +id: GO:0061792 +name: secretory granule maturation +namespace: biological_process +def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0033363 ! secretory granule organization +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of GO:0030141 ! secretory granule +relationship: results_in_maturation_of GO:0030141 ! secretory granule +created_by: dph +creation_date: 2016-09-09T13:24:34Z + [Term] id: GO:0061844 name: antimicrobial humoral immune response mediated by antimicrobial peptide @@ -83936,6 +118229,19 @@ relationship: negatively_regulates GO:0097402 ! neuroblast migration created_by: dph creation_date: 2017-03-08T18:26:21Z +[Term] +id: GO:0061900 +name: glial cell activation +namespace: biological_process +def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082] +is_a: GO:0001775 ! cell activation +intersection_of: GO:0001775 ! cell activation +intersection_of: has_input CL:0000125 ! glial cell +relationship: has_input CL:0000125 ! glial cell +relationship: part_of GO:0150076 ! neuroinflammatory response +created_by: dph +creation_date: 2017-06-13T13:06:23Z + [Term] id: GO:0061938 name: protein localization to somatodendritic compartment @@ -83998,6 +118304,13 @@ relationship: results_in_morphogenesis_of UBERON:0007842 ! membrane bone created_by: dph creation_date: 2018-02-12T18:21:09Z +[Term] +id: GO:0061983 +name: meiosis II cell cycle process +def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [] +synonym: "second meiotic division" EXACT [] +is_a: GO:1903046 ! meiotic cell cycle process + [Term] id: GO:0062012 name: regulation of small molecule metabolic process @@ -84127,6 +118440,22 @@ relationship: part_of GO:0009507 ! chloroplast created_by: dph creation_date: 2020-05-01T12:10:16Z +[Term] +id: GO:0065002 +name: intracellular protein transmembrane transport +namespace: biological_process +def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "intracellular membrane translocation of a protein" EXACT [] +synonym: "intracellular protein membrane transport" EXACT [] +synonym: "intracellular protein transport across a membrane" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0071806 ! protein transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein +intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure +intersection_of: results_in_transport_across GO:0016020 ! membrane + [Term] id: GO:0065003 name: protein-containing complex assembly @@ -84141,6 +118470,7 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe +subset: prokaryote_subset synonym: "cellular macromolecule complex assembly" RELATED [] synonym: "cellular protein complex assembly" EXACT [] synonym: "cellular protein-containing complex assembly" RELATED [] @@ -84206,7 +118536,6 @@ id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] -subset: goslim_mouse is_a: GO:0043233 ! organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0043229 ! intracellular organelle @@ -84267,8 +118596,8 @@ namespace: biological_process def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:5391 ! glucagon -relationship: transports_or_maintains_localization_of CHEBI:5391 ! glucagon +intersection_of: has_primary_input CHEBI:5391 ! glucagon +relationship: has_primary_input CHEBI:5391 ! glucagon [Term] id: GO:0070092 @@ -84526,7 +118855,6 @@ name: regulation of establishment of protein localization to chromosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] -is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0070201 ! regulation of establishment of protein localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070199 ! establishment of protein localization to chromosome @@ -84798,8 +119126,59 @@ namespace: biological_process def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion intersection_of: GO:0046903 ! secretion -intersection_of: transports_or_maintains_localization_of CHEBI:64628 ! somatostatin -relationship: transports_or_maintains_localization_of CHEBI:64628 ! somatostatin +intersection_of: has_primary_input CHEBI:64628 ! somatostatin +relationship: has_primary_input CHEBI:64628 ! somatostatin + +[Term] +id: GO:0070254 +name: mucus secretion +namespace: biological_process +def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] +synonym: "mucus production" EXACT [GOC:add] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0032941 ! secretion by tissue +intersection_of: GO:0046903 ! secretion +intersection_of: has_primary_input UBERON:0000912 ! mucus +relationship: has_primary_input UBERON:0000912 ! mucus + +[Term] +id: GO:0070255 +name: regulation of mucus secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "regulation of mucus production" EXACT [GOC:add] +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051239 ! regulation of multicellular organismal process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0070254 ! mucus secretion +relationship: regulates GO:0070254 ! mucus secretion + +[Term] +id: GO:0070256 +name: negative regulation of mucus secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "negative regulation of mucus production" EXACT [GOC:add] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070255 ! regulation of mucus secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0070254 ! mucus secretion +relationship: negatively_regulates GO:0070254 ! mucus secretion + +[Term] +id: GO:0070257 +name: positive regulation of mucus secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "positive regulation of mucus production" EXACT [GOC:add] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070255 ! regulation of mucus secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0070254 ! mucus secretion +relationship: positively_regulates GO:0070254 ! mucus secretion [Term] id: GO:0070265 @@ -84826,16 +119205,6 @@ namespace: biological_process def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN] is_a: GO:0070276 ! halogen metabolic process -[Term] -id: GO:0070278 -name: extracellular matrix constituent secretion -namespace: biological_process -def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] -synonym: "ECM constituent secretion" EXACT [GOC:mah] -synonym: "ECM secretion" EXACT [GOC:mah] -is_a: GO:0032940 ! secretion by cell -relationship: part_of GO:0030198 ! extracellular matrix organization - [Term] id: GO:0070285 name: pigment cell development @@ -84856,6 +119225,15 @@ synonym: "nephron absorption" EXACT [GOC:mah] synonym: "renal reabsorption" EXACT [GOC:dph] is_a: GO:0003014 ! renal system process +[Term] +id: GO:0070295 +name: renal water absorption +def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [] +synonym: "nephron water absorption" EXACT [] +synonym: "renal water reabsorption" EXACT [] +is_a: GO:0003097 ! renal water transport +is_a: GO:0070293 ! renal absorption + [Term] id: GO:0070341 name: fat cell proliferation @@ -84915,6 +119293,64 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070341 ! fat cell proliferation relationship: positively_regulates GO:0070341 ! fat cell proliferation +[Term] +id: GO:0070365 +name: hepatocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] +synonym: "liver cell differentiation" EXACT [GOC:mah] +is_a: GO:0030855 ! epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000182 ! hepatocyte +relationship: part_of GO:0001889 ! liver development +relationship: results_in_acquisition_of_features_of CL:0000182 ! hepatocyte + +[Term] +id: GO:0070366 +name: regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0070365 ! hepatocyte differentiation +relationship: regulates GO:0070365 ! hepatocyte differentiation + +[Term] +id: GO:0070367 +name: negative regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070366 ! regulation of hepatocyte differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0070365 ! hepatocyte differentiation +relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation + +[Term] +id: GO:0070368 +name: positive regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] +synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070366 ! regulation of hepatocyte differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0070365 ! hepatocyte differentiation +relationship: positively_regulates GO:0070365 ! hepatocyte differentiation + [Term] id: GO:0070382 name: exocytic vesicle @@ -85071,6 +119507,20 @@ is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0016020 ! membrane property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/12846 xsd:anyURI +[Term] +id: GO:0070482 +name: response to oxygen levels +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0070483 +name: detection of hypoxia +def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [] +synonym: "detection of reduced oxygen levels" EXACT [] +is_a: GO:0001666 ! response to hypoxia +is_a: GO:0003032 ! detection of oxygen + [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization @@ -85146,6 +119596,32 @@ relationship: positively_regulates GO:0031102 ! neuron projection regeneration created_by: mah creation_date: 2009-04-15T01:45:27Z +[Term] +id: GO:0070633 +name: transepithelial transport +namespace: biological_process +def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] +is_a: GO:0006810 ! transport +intersection_of: GO:0006810 ! transport +intersection_of: results_in_transport_across UBERON:0000483 ! epithelium +relationship: results_in_transport_across UBERON:0000483 ! epithelium +created_by: mah +creation_date: 2009-05-06T03:31:02Z + +[Term] +id: GO:0070634 +name: transepithelial ammonium transport +namespace: biological_process +def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] +is_a: GO:0006812 ! cation transport +is_a: GO:0070633 ! transepithelial transport +is_a: GO:0071705 ! nitrogen compound transport +intersection_of: GO:0070633 ! transepithelial transport +intersection_of: has_primary_input CHEBI:28938 ! ammonium +relationship: has_primary_input CHEBI:28938 ! ammonium +created_by: mah +creation_date: 2009-05-06T03:34:43Z + [Term] id: GO:0070661 name: leukocyte proliferation @@ -85216,19 +119692,6 @@ is_a: GO:0051641 ! cellular localization created_by: mah creation_date: 2009-06-16T04:08:29Z -[Term] -id: GO:0070828 -name: heterochromatin organization -namespace: biological_process -def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] -synonym: "heterochromatin organisation" EXACT [GOC:mah] -is_a: GO:0006325 ! chromatin organization -intersection_of: GO:0016043 ! cellular component organization -intersection_of: results_in_organization_of GO:0000792 ! heterochromatin -relationship: results_in_organization_of GO:0000792 ! heterochromatin -created_by: mah -creation_date: 2009-07-23T04:12:48Z - [Term] id: GO:0070831 name: basement membrane assembly @@ -85252,6 +119715,72 @@ is_a: GO:0005102 ! signaling receptor binding created_by: mah creation_date: 2009-08-07T11:23:02Z +[Term] +id: GO:0070857 +name: regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "regulation of bile acid formation" EXACT [GOC:mah] +synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006699 ! bile acid biosynthetic process +relationship: regulates GO:0006699 ! bile acid biosynthetic process +created_by: mah +creation_date: 2009-08-14T03:09:02Z + +[Term] +id: GO:0070858 +name: negative regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] +synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0070857 ! regulation of bile acid biosynthetic process +is_a: GO:1904252 ! negative regulation of bile acid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006699 ! bile acid biosynthetic process +relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process +created_by: mah +creation_date: 2009-08-14T03:16:40Z + +[Term] +id: GO:0070859 +name: positive regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] +synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] +synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0070857 ! regulation of bile acid biosynthetic process +is_a: GO:1904253 ! positive regulation of bile acid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006699 ! bile acid biosynthetic process +relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process +created_by: mah +creation_date: 2009-08-14T03:22:58Z + [Term] id: GO:0070867 name: mating projection tip membrane @@ -85343,7 +119872,10 @@ name: bone maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] is_a: GO:0048799 ! animal organ maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of UBERON:0001474 ! bone element relationship: part_of GO:0060348 ! bone development +relationship: results_in_maturation_of UBERON:0001474 ! bone element created_by: mah creation_date: 2009-10-05T04:35:31Z @@ -85362,17 +119894,6 @@ relationship: occurs_in CL:0000540 ! neuron created_by: mah creation_date: 2009-11-03T02:37:17Z -[Term] -id: GO:0071103 -name: DNA conformation change -namespace: biological_process -def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] -subset: goslim_metagenomics -synonym: "DNA conformation modification" EXACT [GOC:mah] -is_a: GO:0051276 ! chromosome organization -created_by: mah -creation_date: 2009-11-09T11:36:34Z - [Term] id: GO:0071168 name: protein localization to chromatin @@ -85528,12 +120049,50 @@ intersection_of: has_input CHEBI:16646 ! carbohydrate created_by: mah creation_date: 2009-12-10T05:13:33Z +[Term] +id: GO:0071326 +name: cellular response to monosaccharide stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] +is_a: GO:0034284 ! response to monosaccharide +is_a: GO:0071322 ! cellular response to carbohydrate stimulus +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:35381 ! monosaccharide +created_by: mah +creation_date: 2009-12-10T05:27:18Z + +[Term] +id: GO:0071331 +name: cellular response to hexose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] +is_a: GO:0009746 ! response to hexose +is_a: GO:0071326 ! cellular response to monosaccharide stimulus +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:18133 ! hexose +created_by: mah +creation_date: 2009-12-10T05:37:00Z + +[Term] +id: GO:0071333 +name: cellular response to glucose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] +is_a: GO:0001678 ! cellular glucose homeostasis +is_a: GO:0009749 ! response to glucose +is_a: GO:0071331 ! cellular response to hexose stimulus +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:17234 ! glucose +created_by: mah +creation_date: 2009-12-10T05:38:03Z + [Term] id: GO:0071375 name: cellular response to peptide hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043434 ! response to peptide hormone is_a: GO:1901653 ! cellular response to peptide intersection_of: GO:0070887 ! cellular response to chemical stimulus @@ -85935,8 +120494,8 @@ namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:50860 ! organic molecular entity -relationship: transports_or_maintains_localization_of CHEBI:50860 ! organic molecular entity +intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity +relationship: has_primary_input CHEBI:50860 ! organic molecular entity created_by: mah creation_date: 2010-03-08T02:15:14Z @@ -85962,11 +120521,20 @@ namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:51143 ! nitrogen molecular entity -relationship: transports_or_maintains_localization_of CHEBI:51143 ! nitrogen molecular entity +intersection_of: has_primary_input CHEBI:51143 ! nitrogen molecular entity +relationship: has_primary_input CHEBI:51143 ! nitrogen molecular entity created_by: mah creation_date: 2010-03-08T03:56:28Z +[Term] +id: GO:0071707 +name: immunoglobulin heavy chain V-D-J recombination +def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [] +synonym: "immunoglobulin V(D)J joining" BROAD [] +synonym: "immunoglobulin V(D)J recombination" BROAD [] +synonym: "immunoglobulin V-D-J joining" EXACT [] +is_a: GO:0033152 ! immunoglobulin V(D)J recombination + [Term] id: GO:0071708 name: immunoglobulin light chain V-J recombination @@ -86007,6 +120575,18 @@ relationship: results_in_organization_of GO:0005604 ! basement membrane created_by: mah creation_date: 2010-03-10T11:57:10Z +[Term] +id: GO:0071738 +name: IgD immunoglobulin complex +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [] +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071753 +name: IgM immunoglobulin complex +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [] +is_a: GO:0019814 ! immunoglobulin complex + [Term] id: GO:0071763 name: nuclear membrane organization @@ -86036,6 +120616,21 @@ relationship: results_in_organization_of GO:0005640 ! nuclear outer membrane created_by: mah creation_date: 2010-03-29T04:03:37Z +[Term] +id: GO:0071806 +name: protein transmembrane transport +namespace: biological_process +def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "protein membrane transport" EXACT [] +is_a: GO:0015031 ! protein transport +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:36080 ! protein +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: mah +creation_date: 2010-09-03T02:54:26Z + [Term] id: GO:0071826 name: ribonucleoprotein complex subunit organization @@ -86128,10 +120723,11 @@ def: "Any process that results in a change in state or activity of a cell or an comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] -is_a: GO:0071869 ! response to catecholamine +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound intersection_of: GO:0050896 ! response to stimulus -intersection_of: has_input CHEBI:33569 ! noradrenaline -relationship: has_input CHEBI:33569 ! noradrenaline +intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline(1+) +relationship: has_input CHEBI:72587 ! (R)-noradrenaline(1+) created_by: mah creation_date: 2010-09-13T03:31:53Z @@ -86142,10 +120738,10 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] -is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:0071873 ! response to norepinephrine +is_a: GO:1901699 ! cellular response to nitrogen compound intersection_of: GO:0070887 ! cellular response to chemical stimulus -intersection_of: has_input CHEBI:33569 ! noradrenaline +intersection_of: has_input CHEBI:72587 ! (R)-noradrenaline(1+) created_by: mah creation_date: 2010-09-13T03:33:32Z @@ -86182,22 +120778,18 @@ created_by: mah creation_date: 2010-09-14T12:50:40Z [Term] -id: GO:0071897 -name: DNA biosynthetic process -namespace: biological_process -def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah] -synonym: "DNA anabolism" EXACT [GOC:mah] -synonym: "DNA biosynthesis" EXACT [GOC:mah] -synonym: "DNA formation" EXACT [GOC:mah] -synonym: "DNA synthesis" EXACT [GOC:mah] -is_a: GO:0006259 ! DNA metabolic process -is_a: GO:0034645 ! cellular macromolecule biosynthetic process -is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process -intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:16991 ! deoxyribonucleic acid -relationship: has_primary_output CHEBI:16991 ! deoxyribonucleic acid +id: GO:0071890 +name: bicarbonate binding +namespace: molecular_function +def: "Binding to bicarbonate ions (CHO3-)." [GOC:curators] +synonym: "CHO3- ion binding binding" EXACT [] +synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544] +is_a: GO:0043168 ! anion binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:17544 ! hydrogencarbonate +relationship: has_input CHEBI:17544 ! hydrogencarbonate created_by: mah -creation_date: 2010-09-15T02:14:33Z +creation_date: 2010-09-14T01:47:43Z [Term] id: GO:0071944 @@ -86245,7 +120837,10 @@ subset: gocheck_do_not_annotate synonym: "urinary system development" BROAD [GOC:yaf] synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] is_a: GO:0048731 ! system development +intersection_of: GO:0048731 ! system development +intersection_of: results_in_development_of UBERON:0001008 ! renal system relationship: part_of GO:0001655 ! urogenital system development +relationship: results_in_development_of UBERON:0001008 ! renal system created_by: mah creation_date: 2010-01-25T10:31:00Z @@ -86598,6 +121193,7 @@ intersection_of: GO:0035148 ! tube formation intersection_of: results_in_formation_of UBERON:0003914 ! epithelial tube relationship: part_of GO:0060562 ! epithelial tube morphogenesis relationship: results_in_formation_of UBERON:0003914 ! epithelial tube +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22302 xsd:anyURI created_by: mah creation_date: 2010-02-26T02:15:40Z @@ -86606,6 +121202,7 @@ id: GO:0072189 name: ureter development namespace: biological_process def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development created_by: mah @@ -86788,6 +121385,19 @@ relationship: part_of GO:0072273 ! metanephric nephron morphogenesis created_by: mah creation_date: 2010-04-01T03:28:00Z +[Term] +id: GO:0072329 +name: monocarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:35757 ! monocarboxylic acid anion +relationship: has_primary_input CHEBI:35757 ! monocarboxylic acid anion +created_by: mah +creation_date: 2010-11-02T04:41:55Z + [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process @@ -86813,8 +121423,8 @@ def: "The directed movement of compounds that contain sulfur, out of or within a synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:26835 ! sulfur molecular entity -relationship: transports_or_maintains_localization_of CHEBI:26835 ! sulfur molecular entity +intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity +relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity created_by: mah creation_date: 2010-11-11T11:43:56Z @@ -86850,11 +121460,11 @@ creation_date: 2010-11-16T11:46:55Z id: GO:0072376 name: protein activation cascade namespace: biological_process -def: "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde] +def: "A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde] synonym: "protein activation pathway" EXACT [GOC:add] synonym: "protein activitory cascade" EXACT [GOC:add] -is_a: GO:0019538 ! protein metabolic process -is_a: GO:0050896 ! response to stimulus +is_a: GO:0051604 ! protein maturation +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/23378 xsd:anyURI created_by: mah creation_date: 2010-11-22T02:54:18Z @@ -86889,11 +121499,31 @@ synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! transport along microtubule is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input GO:0043226 ! organelle intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:0043226 ! organelle created_by: mah creation_date: 2010-12-01T04:59:11Z +[Term] +id: GO:0072488 +name: ammonium transmembrane transport +namespace: biological_process +alt_id: GO:0015696 +def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ammonia transport" BROAD [] +synonym: "ammonium membrane transport" EXACT [] +synonym: "ammonium transport" BROAD [] +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0098662 ! inorganic cation transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:28938 ! ammonium +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:28938 ! ammonium +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22228 xsd:anyURI +created_by: mah +creation_date: 2010-12-10T10:29:57Z + [Term] id: GO:0072501 name: cellular divalent inorganic anion homeostasis @@ -86985,6 +121615,22 @@ is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: mah creation_date: 2011-01-04T03:03:59Z +[Term] +id: GO:0072522 +name: purine-containing compound biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [] +synonym: "purine and derivative biosynthetic process" EXACT [] +synonym: "purine-containing compound anabolism" EXACT [] +synonym: "purine-containing compound biosynthesis" EXACT [] +synonym: "purine-containing compound formation" EXACT [] +synonym: "purine-containing compound synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0072521 ! purine-containing compound metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + [Term] id: GO:0072527 name: pyrimidine-containing compound metabolic process @@ -87011,6 +121657,22 @@ relationship: has_input CL:0000057 ! fibroblast created_by: mah creation_date: 2011-01-14T04:35:08Z +[Term] +id: GO:0072560 +name: type B pancreatic cell maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] +comment: These processes continue to 60 DPA in Gossypium spp. +synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] +synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] +is_a: GO:0002071 ! glandular epithelial cell maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of CL:0000169 ! type B pancreatic cell +relationship: part_of GO:0003323 ! type B pancreatic cell development +relationship: results_in_maturation_of CL:0000169 ! type B pancreatic cell +created_by: mah +creation_date: 2011-01-27T01:57:14Z + [Term] id: GO:0072574 name: hepatocyte proliferation @@ -87038,7 +121700,10 @@ name: liver morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] is_a: GO:0022612 ! gland morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: results_in_morphogenesis_of UBERON:0002107 ! liver relationship: part_of GO:0001889 ! liver development +relationship: results_in_morphogenesis_of UBERON:0002107 ! liver created_by: mah creation_date: 2011-02-02T03:41:30Z @@ -87103,9 +121768,10 @@ id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] +subset: prokaryote_subset synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [] -is_a: GO:0034613 ! cellular protein localization +is_a: GO:0008104 ! protein localization is_a: GO:0051668 ! localization within membrane intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0016020 ! membrane @@ -87624,6 +122290,29 @@ relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis created_by: tb creation_date: 2009-08-03T10:19:40Z +[Term] +id: GO:0090030 +name: regulation of steroid hormone biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [] +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process + +[Term] +id: GO:0090031 +name: positive regulation of steroid hormone biosynthetic process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process + +[Term] +id: GO:0090032 +name: negative regulation of steroid hormone biosynthetic process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process + [Term] id: GO:0090063 name: positive regulation of microtubule nucleation @@ -87766,11 +122455,12 @@ creation_date: 2009-12-08T02:05:00Z [Term] id: GO:0090139 -name: mitochondrial DNA packaging +name: mitochondrial chromosome packaging namespace: biological_process -def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] -is_a: GO:0036385 ! nucleoid DNA packaging -intersection_of: GO:0006323 ! DNA packaging +def: "A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "mitochondrial DNA packaging" EXACT [] +is_a: GO:0051276 ! chromosome organization +intersection_of: GO:0051276 ! chromosome organization intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion created_by: tb @@ -87819,6 +122509,18 @@ intersection_of: has_target_end_location GO:0016020 ! membrane created_by: tb creation_date: 2009-12-08T03:18:51Z +[Term] +id: GO:0090162 +name: establishment of epithelial cell polarity +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030010 ! establishment of cell polarity +intersection_of: GO:0030010 ! establishment of cell polarity +intersection_of: occurs_in CL:0000066 ! epithelial cell +relationship: occurs_in CL:0000066 ! epithelial cell +created_by: tb +creation_date: 2009-12-08T08:58:27Z + [Term] id: GO:0090166 name: Golgi disassembly @@ -88163,43 +122865,34 @@ creation_date: 2010-02-05T02:56:39Z [Term] id: GO:0090283 name: regulation of protein glycosylation in Golgi -namespace: biological_process -def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] -synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [] +synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [] is_a: GO:0060049 ! regulation of protein glycosylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0033578 ! protein glycosylation in Golgi relationship: regulates GO:0033578 ! protein glycosylation in Golgi -created_by: tb -creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090284 name: positive regulation of protein glycosylation in Golgi -namespace: biological_process -def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] -synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [] +synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [] is_a: GO:0060050 ! positive regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi -created_by: tb -creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090285 name: negative regulation of protein glycosylation in Golgi -namespace: biological_process -def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] -synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [] +synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [] is_a: GO:0060051 ! negative regulation of protein glycosylation is_a: GO:0090283 ! regulation of protein glycosylation in Golgi intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0033578 ! protein glycosylation in Golgi relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi -created_by: tb -creation_date: 2010-02-18T02:43:55Z [Term] id: GO:0090289 @@ -88329,7 +123022,7 @@ is_a: GO:0051224 ! negative regulation of protein transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport relationship: negatively_regulates GO:0006886 ! intracellular protein transport -relationship: negatively_regulates GO:0034613 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/geneontology/go-ontology/issues/13926"} ! cellular protein localization +relationship: negatively_regulates GO:0034613 ! cellular protein localization created_by: tb creation_date: 2010-04-16T03:45:07Z @@ -88346,6 +123039,49 @@ relationship: regulates GO:0006801 ! superoxide metabolic process created_by: tb creation_date: 2010-05-06T02:29:05Z +[Term] +id: GO:0090324 +name: negative regulation of oxidative phosphorylation +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [] +is_a: GO:0002082 ! regulation of oxidative phosphorylation +is_a: GO:1901856 ! negative regulation of cellular respiration +is_a: GO:1903579 ! negative regulation of ATP metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006119 ! oxidative phosphorylation +relationship: negatively_regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0090325 +name: regulation of locomotion involved in locomotory behavior +def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0050795 ! regulation of behavior +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior +relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior + +[Term] +id: GO:0090326 +name: positive regulation of locomotion involved in locomotory behavior +def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior +intersection_of: GO:0050789 ! regulation of biological process +intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior +relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior + +[Term] +id: GO:0090327 +name: negative regulation of locomotion involved in locomotory behavior +def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior +relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior + [Term] id: GO:0090330 name: regulation of platelet aggregation @@ -88374,47 +123110,6 @@ relationship: negatively_regulates GO:0070527 ! platelet aggregation created_by: tb creation_date: 2010-05-14T10:46:08Z -[Term] -id: GO:0090342 -name: regulation of cell aging -namespace: biological_process -def: "Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] -is_a: GO:0050793 ! regulation of developmental process -is_a: GO:0050794 ! regulation of cellular process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0007569 ! cell aging -relationship: regulates GO:0007569 ! cell aging -created_by: tb -creation_date: 2010-06-02T10:12:37Z - -[Term] -id: GO:0090343 -name: positive regulation of cell aging -namespace: biological_process -def: "Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] -is_a: GO:0048522 ! positive regulation of cellular process -is_a: GO:0051094 ! positive regulation of developmental process -is_a: GO:0090342 ! regulation of cell aging -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0007569 ! cell aging -relationship: positively_regulates GO:0007569 ! cell aging -created_by: tb -creation_date: 2010-06-02T10:12:37Z - -[Term] -id: GO:0090344 -name: negative regulation of cell aging -namespace: biological_process -def: "Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] -is_a: GO:0048523 ! negative regulation of cellular process -is_a: GO:0051093 ! negative regulation of developmental process -is_a: GO:0090342 ! regulation of cell aging -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0007569 ! cell aging -relationship: negatively_regulates GO:0007569 ! cell aging -created_by: tb -creation_date: 2010-06-02T10:12:37Z - [Term] id: GO:0090357 name: regulation of tryptophan metabolic process @@ -88484,6 +123179,36 @@ relationship: negatively_regulates GO:0060079 ! excitatory postsynaptic potentia created_by: tb creation_date: 2010-12-15T01:43:12Z +[Term] +id: GO:0090398 +name: cellular senescence +namespace: biological_process +def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF, PMID:28682291] +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0033554 ! cellular response to stress +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22788 xsd:anyURI +created_by: tb +creation_date: 2011-01-05T02:27:08Z + +[Term] +id: GO:0090407 +name: organophosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [] +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0090425 +name: acinar cell differentiation +namespace: biological_process +def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] +is_a: GO:0002067 ! glandular epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0000622 ! acinar cell +relationship: results_in_acquisition_of_features_of CL:0000622 ! acinar cell +created_by: tb +creation_date: 2012-05-04T09:24:48Z + [Term] id: GO:0090435 name: protein localization to nuclear envelope @@ -88510,6 +123235,34 @@ relationship: regulates_levels_of CHEBI:14321 ! glutamate(1-) created_by: tb creation_date: 2012-09-24T14:22:02Z +[Term] +id: GO:0090493 +name: catecholamine uptake +namespace: biological_process +def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] +is_a: GO:0051937 ! catecholamine transport +is_a: GO:0098657 ! import into cell +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33567 ! catecholamine +intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure +intersection_of: has_target_start_location GO:0005576 ! extracellular region +created_by: tb +creation_date: 2012-10-17T11:06:17Z + +[Term] +id: GO:0090494 +name: dopamine uptake +namespace: biological_process +def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb] +is_a: GO:0015872 ! dopamine transport +is_a: GO:0090493 ! catecholamine uptake +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:59905 ! dopaminium(1+) +intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure +intersection_of: has_target_start_location GO:0005576 ! extracellular region +created_by: tb +creation_date: 2012-10-17T11:12:09Z + [Term] id: GO:0090497 name: mesenchymal cell migration @@ -88558,6 +123311,42 @@ relationship: has_target_end_location GO:0005634 ! nucleus created_by: tb creation_date: 2016-07-19T17:00:49Z +[Term] +id: GO:0090727 +name: positive regulation of brood size +namespace: biological_process +def: "Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] +is_a: GO:0060378 ! regulation of brood size +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates_characteristic PATO:0000276 ! brood size +relationship: positively_regulates_characteristic PATO:0000276 ! brood size +created_by: tb +creation_date: 2016-12-19T15:07:32Z + +[Term] +id: GO:0090728 +name: negative regulation of brood size +namespace: biological_process +def: "Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] +is_a: GO:0060378 ! regulation of brood size +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates_characteristic PATO:0000276 ! brood size +relationship: negatively_regulates_characteristic PATO:0000276 ! brood size +created_by: tb +creation_date: 2016-12-19T15:07:32Z + +[Term] +id: GO:0090740 +name: integral component of pigment granule membrane +namespace: cellular_component +def: "The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [PMID:11294610] +is_a: GO:0031301 ! integral component of organelle membrane +intersection_of: GO:0016021 ! integral component of membrane +intersection_of: part_of GO:0090741 ! pigment granule membrane +relationship: part_of GO:0090741 ! pigment granule membrane +created_by: tb +creation_date: 2017-05-16T17:48:35Z + [Term] id: GO:0090741 name: pigment granule membrane @@ -88673,6 +123462,21 @@ relationship: occurs_in CL:0000100 ! motor neuron created_by: pr creation_date: 2011-05-04T02:21:43Z +[Term] +id: GO:0097050 +name: type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305] +synonym: "pancreatic B cell apoptosis" EXACT [] +synonym: "pancreatic beta cell apoptosis" EXACT [] +synonym: "type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904019 ! epithelial cell apoptotic process +intersection_of: GO:0006915 ! apoptotic process +intersection_of: occurs_in CL:0000169 ! type B pancreatic cell +relationship: occurs_in CL:0000169 ! type B pancreatic cell +created_by: pr +creation_date: 2011-05-04T02:24:38Z + [Term] id: GO:0097060 name: synaptic membrane @@ -88722,8 +123526,8 @@ def: "The process in which any suture between cranial and/or facial bones is gen is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0009198 ! craniofacial suture -relationship: in_taxon NCBITaxon:7742 ! Vertebrata -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of GO:0060349 ! bone morphogenesis relationship: part_of GO:1904888 ! cranial skeletal system development relationship: results_in_morphogenesis_of UBERON:0009198 ! craniofacial suture @@ -88766,10 +123570,10 @@ def: "Any process in which a receptor is transported to, and/or maintained at th synonym: "receptor localisation to synapse" EXACT [] is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0051179 ! localization +intersection_of: has_primary_input GO:0098802 ! plasma membrane signaling receptor complex intersection_of: has_target_end_location GO:0045202 ! synapse -intersection_of: transports_or_maintains_localization_of GO:0098802 ! plasma membrane signaling receptor complex +relationship: has_primary_input GO:0098802 ! plasma membrane signaling receptor complex relationship: has_target_end_location GO:0045202 ! synapse -relationship: transports_or_maintains_localization_of GO:0098802 ! plasma membrane signaling receptor complex created_by: pr creation_date: 2011-07-31T09:20:30Z @@ -88828,7 +123632,7 @@ id: GO:0097190 name: apoptotic signaling pathway namespace: biological_process alt_id: GO:0008624 -def: "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] +def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. synonym: "apoptotic signalling pathway" EXACT [GOC:mah] synonym: "induction of apoptosis by extracellular signals" EXACT [] @@ -88900,6 +123704,7 @@ namespace: cellular_component def: "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831] is_a: GO:0110165 ! cellular anatomical entity relationship: part_of GO:0036126 ! sperm flagellum +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22313 xsd:anyURI created_by: pr creation_date: 2012-01-25T01:23:41Z @@ -88907,9 +123712,11 @@ creation_date: 2012-01-25T01:23:41Z id: GO:0097226 name: sperm mitochondrial sheath namespace: cellular_component -def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832] +def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832, PMID:32791035] is_a: GO:0110165 ! cellular anatomical entity -relationship: part_of GO:0036126 ! sperm flagellum +relationship: part_of GO:0097225 ! sperm midpiece +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21361 xsd:anyURI +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22313 xsd:anyURI created_by: pr creation_date: 2012-01-25T01:25:08Z @@ -89006,6 +123813,19 @@ property_value: RO:0002161 NCBITaxon:6656 created_by: pr creation_date: 2012-03-29T10:20:51Z +[Term] +id: GO:0097284 +name: hepatocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020] +synonym: "hepatocyte apoptosis" NARROW [] +is_a: GO:1904019 ! epithelial cell apoptotic process +intersection_of: GO:0006915 ! apoptotic process +intersection_of: occurs_in CL:0000182 ! hepatocyte +relationship: occurs_in CL:0000182 ! hepatocyte +created_by: pr +creation_date: 2012-03-29T10:23:21Z + [Term] id: GO:0097305 name: response to alcohol @@ -89043,6 +123863,18 @@ relationship: has_target_end_location GO:0000792 ! heterochromatin created_by: pr creation_date: 2012-07-03T03:19:07Z +[Term] +id: GO:0097360 +name: chorionic trophoblast cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278] +is_a: GO:0008283 ! cell population proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:0011101 ! chorionic trophoblast cell +relationship: acts_on_population_of CL:0011101 ! chorionic trophoblast cell +created_by: pr +creation_date: 2012-07-19T10:17:37Z + [Term] id: GO:0097367 name: carbohydrate derivative binding @@ -89137,6 +123969,20 @@ relationship: part_of GO:0036477 ! somatodendritic compartment created_by: pr creation_date: 2012-12-17T12:31:49Z +[Term] +id: GO:0097454 +name: Schwann cell microvillus +namespace: cellular_component +def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042] +xref: NIF_Subcellular:sao1890444066 +is_a: GO:0005902 ! microvillus +is_a: GO:0097386 ! glial cell projection +intersection_of: GO:0005902 ! microvillus +intersection_of: part_of CL:0002573 ! Schwann cell +relationship: part_of CL:0002573 ! Schwann cell +created_by: pr +creation_date: 2012-12-19T13:01:02Z + [Term] id: GO:0097457 name: hippocampal mossy fiber @@ -89223,8 +124069,10 @@ synonym: "neuron process guidance" EXACT [] synonym: "neuron protrusion guidance" EXACT [] synonym: "neuronal cell projection guidance" EXACT [] is_a: GO:0006928 ! movement of cell or subcellular component +is_a: GO:0031175 ! neuron projection development relationship: part_of GO:0006935 ! chemotaxis relationship: part_of GO:0048812 ! neuron projection morphogenesis +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/19809 xsd:anyURI created_by: pr creation_date: 2013-07-08T13:32:37Z @@ -89417,7 +124265,7 @@ id: GO:0097621 name: monoamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2." [GOC:pr, RHEA:26414] -comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC:1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. +comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC:1.4.3.21, primary amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. synonym: "amine:oxygen oxidoreductase (deaminating) activity" EXACT [] xref: EC:1.4.3.4 xref: RHEA:26414 @@ -89714,6 +124562,7 @@ namespace: biological_process alt_id: GO:0009814 def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] subset: goslim_generic +subset: prokaryote_subset synonym: "defence response incompatible interaction" NARROW [] synonym: "defence response to pathogen, incompatible interaction" NARROW [] synonym: "defense response, incompatible interaction" NARROW [] @@ -89790,14 +124639,17 @@ creation_date: 2014-04-16T13:40:03Z id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function -def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] +def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] +def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell." [] subset: goslim_generic +subset: prokaryote_subset synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: part_of GO:0007155 ! cell adhesion relationship: part_of GO:0007155 ! cell adhesion +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22959 xsd:anyURI [Term] id: GO:0098632 @@ -89900,6 +124752,32 @@ intersection_of: GO:0005581 ! collagen trimer intersection_of: part_of GO:0005604 ! basement membrane relationship: part_of GO:0005604 ! basement membrane +[Term] +id: GO:0098655 +name: cation transmembrane transport +namespace: biological_process +alt_id: GO:0099132 +def: "The process in which a cation is transported across a membrane." [GOC:dos, GOC:vw] +synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0034220 ! ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:36916 ! cation +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0098656 +name: anion transmembrane transport +namespace: biological_process +alt_id: GO:0099133 +def: "The process in which an anion is transported across a membrane." [GOC:dos, GOC:vw] +synonym: "ATP hydrolysis coupled anion transmembrane transport" NARROW [] +is_a: GO:0006820 ! anion transport +is_a: GO:0034220 ! ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:22563 ! anion +intersection_of: results_in_transport_across GO:0016020 ! membrane + [Term] id: GO:0098657 name: import into cell @@ -89908,12 +124786,60 @@ def: "The directed movement of some substance from outside of a cell into a cell synonym: "uptake" BROAD [] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24431 ! chemical entity intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure intersection_of: has_target_start_location GO:0005576 ! extracellular region -intersection_of: transports_or_maintains_localization_of CHEBI:24431 ! chemical entity +relationship: has_primary_input CHEBI:24431 ! chemical entity relationship: has_target_end_location GO:0005622 ! intracellular anatomical structure relationship: has_target_start_location GO:0005576 ! extracellular region -relationship: transports_or_maintains_localization_of CHEBI:24431 ! chemical entity + +[Term] +id: GO:0098660 +name: inorganic ion transmembrane transport +namespace: biological_process +def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "inorganic ion membrane transport" EXACT [] +synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034220 ! ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:36914 ! inorganic ion +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:36914 ! inorganic ion + +[Term] +id: GO:0098661 +name: inorganic anion transmembrane transport +namespace: biological_process +def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "inorganic anion membrane transport" EXACT [] +synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098660 ! inorganic ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24834 ! inorganic anion +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0098662 +name: inorganic cation transmembrane transport +namespace: biological_process +alt_id: GO:0015672 +alt_id: GO:0072511 +def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "divalent inorganic cation transport" NARROW [] +synonym: "inorganic cation membrane transport" EXACT [] +synonym: "monovalent inorganic cation transport" NARROW [] +synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098660 ! inorganic ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:36915 ! inorganic cation +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:36915 ! inorganic cation [Term] id: GO:0098664 @@ -89991,6 +124917,16 @@ relationship: regulates GO:0099504 ! synaptic vesicle cycle created_by: dos creation_date: 2017-03-21T16:06:48Z +[Term] +id: GO:0098722 +name: asymmetric stem cell division +namespace: biological_process +def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0017145 ! stem cell division +intersection_of: GO:0008356 ! asymmetric cell division +intersection_of: has_input CL:0000034 ! stem cell + [Term] id: GO:0098723 name: skeletal muscle myofibril @@ -90001,6 +124937,16 @@ intersection_of: GO:0030016 ! myofibril intersection_of: part_of CL:0008002 ! skeletal muscle fiber relationship: part_of CL:0008002 ! skeletal muscle fiber +[Term] +id: GO:0098728 +name: germline stem cell asymmetric division +namespace: biological_process +def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] +is_a: GO:0042078 ! germ-line stem cell division +is_a: GO:0098722 ! asymmetric stem cell division +intersection_of: GO:0008356 ! asymmetric cell division +intersection_of: has_input CL:0000014 ! germ line stem cell + [Term] id: GO:0098732 name: macromolecule deacylation @@ -90035,6 +124981,7 @@ namespace: biological_process def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] subset: goslim_generic subset: goslim_pombe +subset: prokaryote_subset is_a: GO:0008150 ! biological_process relationship: part_of GO:0009636 ! response to toxic substance @@ -90048,6 +124995,21 @@ intersection_of: GO:0042592 ! homeostatic process intersection_of: regulates_levels_of CHEBI:36914 ! inorganic ion relationship: regulates_levels_of CHEBI:36914 ! inorganic ion +[Term] +id: GO:0098772 +name: molecular function regulator activity +namespace: molecular_function +def: "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] +subset: gocheck_do_not_annotate +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: prokaryote_subset +synonym: "molecular function regulator" EXACT [] +is_a: GO:0003674 ! molecular_function +relationship: has_part GO:0005515 ! protein binding +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20854 xsd:anyURI +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20862 xsd:anyURI + [Term] id: GO:0098773 name: skin epidermis development @@ -90196,6 +125158,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050804 ! modulation of chemical synaptic transmission intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0060079 ! excitatory postsynaptic potential @@ -90244,8 +125207,8 @@ is_a: GO:0006886 ! intracellular protein transport is_a: GO:0010970 ! transport along microtubule is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein [Term] id: GO:0098845 @@ -90322,6 +125285,7 @@ def: "The increase in size or mass of a bone that contributes to the shaping of is_a: GO:0035265 ! organ growth intersection_of: GO:0048589 ! developmental growth intersection_of: results_in_growth_of UBERON:0001474 ! bone element +relationship: part_of GO:0060348 ! bone development relationship: results_in_growth_of UBERON:0001474 ! bone element [Term] @@ -90366,8 +125330,8 @@ is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:1990778 ! protein localization to cell periphery intersection_of: GO:0015031 ! protein transport +intersection_of: has_primary_input GO:0098878 ! neurotransmitter receptor complex intersection_of: has_target_end_location GO:0005886 ! plasma membrane -intersection_of: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex [Term] id: GO:0098878 @@ -90401,6 +125365,7 @@ name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. +is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0050789 ! regulation of biological process intersection_of: regulates GO:0001508 ! action potential @@ -90652,11 +125617,11 @@ synonym: "dendritic transport of RNP complex" EXACT [] is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0098935 ! dendritic transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:1990904 ! ribonucleoprotein complex intersection_of: occurs_in GO:0032839 ! dendrite cytoplasm intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:1990904 ! ribonucleoprotein complex +relationship: has_primary_input GO:1990904 ! ribonucleoprotein complex relationship: occurs_in GO:0032839 ! dendrite cytoplasm -relationship: transports_or_maintains_localization_of GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0098962 @@ -90694,8 +125659,8 @@ is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane intersection_of: GO:0015031 ! protein transport +intersection_of: has_primary_input GO:0098878 ! neurotransmitter receptor complex intersection_of: has_target_end_location GO:0045211 ! postsynaptic membrane -intersection_of: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex [Term] id: GO:0098971 @@ -90706,11 +125671,11 @@ subset: goslim_synapse is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0098937 ! anterograde dendritic transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0098878 ! neurotransmitter receptor complex intersection_of: has_target_end_location GO:0098794 ! postsynapse intersection_of: occurs_in GO:0032839 ! dendrite cytoplasm intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex -relationship: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex +relationship: has_primary_input GO:0098878 ! neurotransmitter receptor complex [Term] id: GO:0098974 @@ -90974,8 +125939,8 @@ is_a: GO:0099098 ! microtubule polymerization based movement is_a: GO:0099118 ! microtubule-based protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: has_part GO:0046785 ! microtubule polymerization +intersection_of: has_primary_input CHEBI:36080 ! protein intersection_of: process_has_causal_agent GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of CHEBI:36080 ! protein [Term] id: GO:0099118 @@ -90985,8 +125950,8 @@ def: "A microtubule-based process that results in the transport of proteins." [G is_a: GO:0015031 ! protein transport is_a: GO:0099111 ! microtubule-based transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: process_has_causal_agent GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein [Term] id: GO:0099123 @@ -91100,6 +126065,15 @@ intersection_of: process_has_causal_agent GO:0070062 ! extracellular exosome created_by: dos creation_date: 2017-07-05T16:49:44Z +[Term] +id: GO:0099160 +name: postsynaptic intermediate filament cytoskeleton +def: "The intermediate filament cytoskeleton that is part of a postsynapse." [] +is_a: GO:0045111 ! intermediate filament cytoskeleton +is_a: GO:0099571 ! postsynaptic cytoskeleton +intersection_of: GO:0045111 ! intermediate filament cytoskeleton +intersection_of: part_of GO:0098794 ! postsynapse + [Term] id: GO:0099164 name: postsynaptic specialization membrane of symmetric synapse @@ -91251,6 +126225,15 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0099537 ! trans-synaptic signaling relationship: regulates GO:0099537 ! trans-synaptic signaling +[Term] +id: GO:0099182 +name: presynaptic intermediate filament cytoskeleton +def: "The intermediate filament cytoskeleton that is part of a presynapse." [] +is_a: GO:0045111 ! intermediate filament cytoskeleton +is_a: GO:0099569 ! presynaptic cytoskeleton +intersection_of: GO:0045111 ! intermediate filament cytoskeleton +intersection_of: part_of GO:0098793 ! presynapse + [Term] id: GO:0099187 name: presynaptic cytoskeleton organization @@ -91361,6 +126344,18 @@ intersection_of: bearer_of PATO:0015006 ! polymeric intersection_of: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton +[Term] +id: GO:0099515 +name: actin filament-based transport +namespace: biological_process +def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport +intersection_of: GO:0046907 ! intracellular transport +intersection_of: results_in_transport_along GO:0005884 ! actin filament +relationship: results_in_transport_along GO:0005884 ! actin filament +created_by: tb +creation_date: 2009-05-27T10:56:08Z + [Term] id: GO:0099518 name: vesicle cytoskeletal trafficking @@ -91371,8 +126366,8 @@ synonym: "vesicle cytoskeletal transport" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input GO:0031982 ! vesicle intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber -intersection_of: transports_or_maintains_localization_of GO:0031982 ! vesicle [Term] id: GO:0099522 @@ -91511,6 +126506,21 @@ intersection_of: GO:0099537 ! trans-synaptic signaling intersection_of: process_has_causal_agent CHEBI:18059 ! lipid relationship: process_has_causal_agent CHEBI:18059 ! lipid +[Term] +id: GO:0099546 +name: protein catabolic process, modulating synaptic transmission +namespace: biological_process +def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0045202 ! synapse +intersection_of: regulates GO:0007268 ! chemical synaptic transmission +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: regulates GO:0007268 ! chemical synaptic transmission + [Term] id: GO:0099547 name: regulation of translation at synapse, modulating synaptic transmission @@ -91621,6 +126631,48 @@ def: "A network of proteins within and adjacent to the postsynaptic membrane. It subset: goslim_synapse is_a: GO:0099091 ! postsynaptic specialization, intracellular component +[Term] +id: GO:0099574 +name: regulation of protein catabolic process at synapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0140250 ! regulation protein catabolic process at synapse +intersection_of: GO:0065007 ! biological regulation +intersection_of: has_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0045202 ! synapse +intersection_of: regulates GO:0007268 ! chemical synaptic transmission +intersection_of: regulates GO:0009056 ! catabolic process +relationship: in_taxon NCBITaxon:33208 ! Metazoa + +[Term] +id: GO:0099575 +name: regulation of protein catabolic process at presynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission +intersection_of: GO:0042176 ! regulation of protein catabolic process +intersection_of: occurs_in GO:0098793 ! presynapse +intersection_of: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099576 +name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission +intersection_of: GO:0042176 ! regulation of protein catabolic process +intersection_of: occurs_in GO:0098794 ! postsynapse +intersection_of: regulates GO:0007268 ! chemical synaptic transmission + [Term] id: GO:0099577 name: regulation of translation at presynapse, modulating synaptic transmission @@ -91685,6 +126737,16 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030594 ! neurotransmitter receptor activity relationship: regulates GO:0030594 ! neurotransmitter receptor activity +[Term] +id: GO:0099602 +name: neurotransmitter receptor regulator activity +namespace: molecular_function +def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:18387948] +is_a: GO:0030545 ! signaling receptor regulator activity +intersection_of: GO:0098772 ! molecular function regulator activity +intersection_of: regulates GO:0030594 ! neurotransmitter receptor activity +relationship: regulates GO:0030594 ! neurotransmitter receptor activity + [Term] id: GO:0099612 name: protein localization to axon @@ -91714,8 +126776,8 @@ namespace: biological_process def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] is_a: GO:0032594 ! protein transport within lipid bilayer intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: occurs_in GO:0005886 ! plasma membrane -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein relationship: occurs_in GO:0005886 ! plasma membrane [Term] @@ -91740,8 +126802,8 @@ subset: goslim_synapse is_a: GO:0015031 ! protein transport is_a: GO:0031503 ! protein-containing complex localization intersection_of: GO:0015031 ! protein transport -intersection_of: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex -relationship: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex +intersection_of: has_primary_input GO:0098878 ! neurotransmitter receptor complex +relationship: has_primary_input GO:0098878 ! neurotransmitter receptor complex [Term] id: GO:0099640 @@ -91753,9 +126815,9 @@ synonym: "axonal protein transport" NARROW [] is_a: GO:0008088 ! axo-dendritic transport is_a: GO:0098840 ! protein transport along microtubule intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: occurs_in GO:0043005 ! neuron projection intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein [Term] id: GO:0099641 @@ -91768,10 +126830,10 @@ is_a: GO:0008089 ! anterograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport is_a: GO:1905383 ! protein localization to presynapse intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: has_target_end_location GO:0098793 ! presynapse intersection_of: occurs_in GO:1904115 ! axon cytoplasm intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein [Term] id: GO:0099642 @@ -91783,10 +126845,10 @@ synonym: "retrograde axon cargo transport" BROAD [] is_a: GO:0008090 ! retrograde axonal transport is_a: GO:0099640 ! axo-dendritic protein transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein intersection_of: has_target_start_location GO:0098793 ! presynapse intersection_of: occurs_in GO:1904115 ! axon cytoplasm intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of PR:000000001 ! protein [Term] id: GO:0099643 @@ -91838,6 +126900,18 @@ intersection_of: regulates GO:0003009 ! skeletal muscle contraction created_by: cjm creation_date: 2015-04-02T04:13:19Z +[Term] +id: GO:0100002 +name: negative regulation of protein kinase activity by protein phosphorylation +namespace: biological_process +def: "Any protein phosphorylation process that negatively regulates protein kinase activity." [GOC:cjm, GOC:obol] +is_a: GO:0006468 ! protein phosphorylation +intersection_of: GO:0006468 ! protein phosphorylation +intersection_of: negatively_regulates GO:0004672 ! protein kinase activity +relationship: negatively_regulates GO:0004672 ! protein kinase activity +created_by: cjm +creation_date: 2015-04-02T04:13:19Z + [Term] id: GO:0101023 name: vascular endothelial cell proliferation @@ -92139,6 +127213,19 @@ relationship: positively_regulates GO:0110040 ! pharynx morphogenesis created_by: kmv creation_date: 2017-07-24T21:09:48Z +[Term] +id: GO:0110053 +name: regulation of actin filament organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0007015 ! actin filament organization +relationship: regulates GO:0007015 ! actin filament organization +created_by: kmv +creation_date: 2017-09-20T19:52:57Z + [Term] id: GO:0110057 name: regulation of blood vessel endothelial cell differentiation @@ -92177,6 +127264,57 @@ relationship: negatively_regulates GO:0060837 ! blood vessel endothelial cell di created_by: kmv creation_date: 2017-10-23T14:47:29Z +[Term] +id: GO:0110077 +name: vesicle-mediated intercellular transport +namespace: biological_process +def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] +is_a: GO:0010496 ! intercellular transport +is_a: GO:0016192 ! vesicle-mediated transport +intersection_of: GO:0010496 ! intercellular transport +intersection_of: process_has_causal_agent GO:1903561 ! extracellular vesicle +relationship: process_has_causal_agent GO:1903561 ! extracellular vesicle +created_by: kmv +creation_date: 2018-01-29T14:46:52Z + +[Term] +id: GO:0110079 +name: regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:1901342 ! regulation of vasculature development +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0060674 ! placenta blood vessel development +relationship: regulates GO:0060674 ! placenta blood vessel development +created_by: kmv +creation_date: 2018-02-01T14:49:12Z + +[Term] +id: GO:0110080 +name: positive regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0110079 ! regulation of placenta blood vessel development +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0060674 ! placenta blood vessel development +relationship: positively_regulates GO:0060674 ! placenta blood vessel development +created_by: kmv +creation_date: 2018-02-01T14:55:30Z + +[Term] +id: GO:0110081 +name: negative regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0110079 ! regulation of placenta blood vessel development +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0060674 ! placenta blood vessel development +relationship: negatively_regulates GO:0060674 ! placenta blood vessel development +created_by: kmv +creation_date: 2018-02-01T15:01:11Z + [Term] id: GO:0110110 name: positive regulation of animal organ morphogenesis @@ -92205,6 +127343,47 @@ relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis created_by: kmv creation_date: 2018-07-05T14:25:21Z +[Term] +id: GO:0110112 +name: regulation of lipid transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0032409 ! regulation of transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0005319 ! lipid transporter activity +relationship: regulates GO:0005319 ! lipid transporter activity +created_by: kmv +creation_date: 2018-07-06T18:53:55Z + +[Term] +id: GO:0110113 +name: positive regulation of lipid transporter activity +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0110112 ! regulation of lipid transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0005319 ! lipid transporter activity +relationship: positively_regulates GO:0005319 ! lipid transporter activity +created_by: kmv +creation_date: 2018-07-06T19:14:13Z + +[Term] +id: GO:0110114 +name: negative regulation of lipid transporter activity +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0110112 ! regulation of lipid transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0005319 ! lipid transporter activity +relationship: negatively_regulates GO:0005319 ! lipid transporter activity +created_by: kmv +creation_date: 2018-07-06T19:21:44Z + [Term] id: GO:0110116 name: regulation of compound eye photoreceptor cell differentiation @@ -92539,6 +127718,7 @@ is_a: GO:0070663 ! regulation of leukocyte proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061517 ! macrophage proliferation relationship: regulates GO:0061517 ! macrophage proliferation +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13470 xsd:anyURI created_by: krc creation_date: 2017-05-10T20:38:19Z @@ -92552,6 +127732,7 @@ is_a: GO:0120040 ! regulation of macrophage proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0061517 ! macrophage proliferation relationship: positively_regulates GO:0061517 ! macrophage proliferation +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13470 xsd:anyURI created_by: krc creation_date: 2017-05-10T20:45:01Z @@ -92565,6 +127746,7 @@ is_a: GO:0120040 ! regulation of macrophage proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0061517 ! macrophage proliferation relationship: negatively_regulates GO:0061517 ! macrophage proliferation +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13470 xsd:anyURI created_by: krc creation_date: 2017-05-10T20:51:40Z @@ -92579,6 +127761,7 @@ is_a: GO:1905333 ! regulation of gastric motility intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035483 ! gastric emptying relationship: regulates GO:0035483 ! gastric emptying +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13607 xsd:anyURI created_by: krc creation_date: 2017-06-13T21:47:16Z @@ -92592,6 +127775,7 @@ is_a: GO:0120060 ! regulation of gastric emptying intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035483 ! gastric emptying relationship: negatively_regulates GO:0035483 ! gastric emptying +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13607 xsd:anyURI created_by: krc creation_date: 2017-06-13T21:54:49Z @@ -92605,6 +127789,7 @@ is_a: GO:0120060 ! regulation of gastric emptying intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035483 ! gastric emptying relationship: positively_regulates GO:0035483 ! gastric emptying +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/13607 xsd:anyURI created_by: krc creation_date: 2017-06-13T21:55:08Z @@ -92618,21 +127803,51 @@ is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0043005 ! neuron projection relationship: part_of GO:0043005 ! neuron projection +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14472 xsd:anyURI created_by: krc creation_date: 2017-11-01T18:58:12Z +[Term] +id: GO:0120158 +name: positive regulation of collagen catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010710 ! regulation of collagen catabolic process +is_a: GO:0010714 ! positive regulation of collagen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0030574 ! collagen catabolic process +relationship: positively_regulates GO:0030574 ! collagen catabolic process +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/15720 xsd:anyURI +created_by: krc +creation_date: 2018-05-11T16:31:42Z + +[Term] +id: GO:0120178 +name: steroid hormone biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process + [Term] id: GO:0120186 name: negative regulation of protein localization to chromatin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0071168 ! protein localization to chromatin relationship: negatively_regulates GO:0071168 ! protein localization to chromatin +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16012 xsd:anyURI created_by: krc creation_date: 2018-07-14T00:19:32Z @@ -92642,15 +127857,59 @@ name: positive regulation of protein localization to chromatin namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905634 ! regulation of protein localization to chromatin intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0071168 ! protein localization to chromatin relationship: positively_regulates GO:0071168 ! protein localization to chromatin +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16012 xsd:anyURI created_by: krc creation_date: 2018-07-14T00:21:28Z +[Term] +id: GO:0120188 +name: regulation of bile acid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051046 ! regulation of secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0032782 ! bile acid secretion +relationship: regulates GO:0032782 ! bile acid secretion +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI +created_by: krc +creation_date: 2018-07-16T22:28:58Z + +[Term] +id: GO:0120189 +name: positive regulation of bile acid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0120188 ! regulation of bile acid secretion +is_a: GO:1903793 ! positive regulation of anion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0032782 ! bile acid secretion +relationship: positively_regulates GO:0032782 ! bile acid secretion +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI +created_by: krc +creation_date: 2018-07-16T22:36:17Z + +[Term] +id: GO:0120190 +name: negative regulation of bile acid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0120188 ! regulation of bile acid secretion +is_a: GO:1903792 ! negative regulation of anion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0032782 ! bile acid secretion +relationship: negatively_regulates GO:0032782 ! bile acid secretion +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/16040 xsd:anyURI +created_by: krc +creation_date: 2018-07-16T22:38:34Z + [Term] id: GO:0120222 name: regulation of blastocyst development @@ -92660,6 +127919,7 @@ is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001824 ! blastocyst development relationship: regulates GO:0001824 ! blastocyst development +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18871 xsd:anyURI created_by: krc creation_date: 2020-02-17T19:59:20Z @@ -92674,6 +127934,7 @@ intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of UBERON:0001737 ! larynx relationship: part_of GO:0120224 ! larynx development relationship: results_in_morphogenesis_of UBERON:0001737 ! larynx +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18924 xsd:anyURI created_by: krc creation_date: 2020-02-22T01:42:04Z @@ -92687,6 +127948,7 @@ intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0001737 ! larynx relationship: part_of GO:0060541 ! respiratory system development relationship: results_in_development_of UBERON:0001737 ! larynx +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/18924 xsd:anyURI created_by: krc creation_date: 2020-02-24T17:13:10Z @@ -92716,56 +127978,6 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/1 created_by: krc creation_date: 2020-09-02T23:13:44Z -[Term] -id: GO:0120261 -name: regulation of heterochromatin organization -namespace: biological_process -def: "Any process that modulates the frequency, rate, extent or location of heterochromatin organization." [GOC:krc] -is_a: GO:1902275 ! regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0070828 ! heterochromatin organization -relationship: regulates GO:0070828 ! heterochromatin organization -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20020 xsd:anyURI -created_by: krc -creation_date: 2020-09-29T20:00:04Z - -[Term] -id: GO:0120262 -name: negative regulation of heterochromatin organization -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization." [GOC:krc] -synonym: "down regulation of heterochromatin organization" EXACT [] -synonym: "down-regulation of heterochromatin organization" EXACT [] -synonym: "downregulation of heterochromatin organization" EXACT [] -synonym: "inhibition of heterochromatin organization" NARROW [] -is_a: GO:0120261 ! regulation of heterochromatin organization -is_a: GO:1905268 ! negative regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0070828 ! heterochromatin organization -relationship: negatively_regulates GO:0070828 ! heterochromatin organization -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20020 xsd:anyURI -created_by: krc -creation_date: 2020-09-29T20:12:30Z - -[Term] -id: GO:0120263 -name: positive regulation of heterochromatin organization -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of heterochromatin organization." [GOC:krc] -synonym: "activation of heterochromatin organization" NARROW [] -synonym: "stimulation of heterochromatin organization" NARROW [] -synonym: "up regulation of heterochromatin organization" EXACT [] -synonym: "up-regulation of heterochromatin organization" EXACT [] -synonym: "upregulation of heterochromatin organization" EXACT [] -is_a: GO:0120261 ! regulation of heterochromatin organization -is_a: GO:1905269 ! positive regulation of chromatin organization -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0070828 ! heterochromatin organization -relationship: positively_regulates GO:0070828 ! heterochromatin organization -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20020 xsd:anyURI -created_by: krc -creation_date: 2020-09-29T20:19:19Z - [Term] id: GO:0120275 name: cerebral blood circulation @@ -92849,6 +128061,30 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/2 created_by: krc creation_date: 2021-02-09T19:37:35Z +[Term] +id: GO:0120316 +name: sperm flagellum assembly +def: "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0044458 ! motile cilium assembly +relationship: part_of GO:0007286 ! spermatid development +relationship: part_of GO:0030317 ! flagellated sperm motility + +[Term] +id: GO:0120331 +name: endothelial tube formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824] +is_a: GO:0072175 ! epithelial tube formation +intersection_of: GO:0035148 ! tube formation +intersection_of: results_in_formation_of UBERON:0003915 ! endothelial tube +relationship: part_of GO:0061154 ! endothelial tube morphogenesis +relationship: results_in_formation_of UBERON:0003915 ! endothelial tube +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22302 xsd:anyURI +created_by: krc +creation_date: 2022-05-25T16:17:59Z + [Term] id: GO:0140013 name: meiotic nuclear division @@ -92924,6 +128160,7 @@ name: catalytic activity, acting on a protein namespace: molecular_function def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic +subset: prokaryote_subset is_a: GO:0003824 ! catalytic activity intersection_of: GO:0003824 ! catalytic activity intersection_of: has_input PR:000000001 ! protein @@ -92932,26 +128169,13 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/1 created_by: pg creation_date: 2017-09-14T10:32:59Z -[Term] -id: GO:0140097 -name: catalytic activity, acting on DNA -namespace: molecular_function -def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] -subset: goslim_generic -is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid -intersection_of: GO:0003824 ! catalytic activity -intersection_of: has_input CHEBI:16991 ! deoxyribonucleic acid -relationship: has_input CHEBI:16991 ! deoxyribonucleic acid -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI -created_by: pg -creation_date: 2017-09-14T12:03:51Z - [Term] id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function def: "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt] subset: goslim_generic +subset: prokaryote_subset is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid intersection_of: GO:0003824 ! catalytic activity intersection_of: has_input CHEBI:33697 ! ribonucleic acid @@ -93009,10 +128233,10 @@ is_a: GO:0097120 ! receptor localization to synapse is_a: GO:0099637 ! neurotransmitter receptor transport is_a: GO:0099641 ! anterograde axonal protein transport intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0098878 ! neurotransmitter receptor complex intersection_of: has_target_end_location GO:0098793 ! presynapse intersection_of: occurs_in GO:1904115 ! axon cytoplasm intersection_of: results_in_transport_along GO:0005874 ! microtubule -intersection_of: transports_or_maintains_localization_of GO:0098878 ! neurotransmitter receptor complex created_by: pg creation_date: 2018-07-09T09:41:37Z @@ -93129,6 +128353,110 @@ property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 x created_by: pg creation_date: 2018-07-15T09:38:54Z +[Term] +id: GO:0140246 +name: protein catabolic process at synapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0030163 ! protein catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0045202 ! synapse +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: occurs_in GO:0045202 ! synapse +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/210 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:12:51Z + +[Term] +id: GO:0140247 +name: protein catabolic process at presynapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0098793 ! presynapse +relationship: occurs_in GO:0098793 ! presynapse +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:23:49Z + +[Term] +id: GO:0140249 +name: protein catabolic process at postsynapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0098794 ! postsynapse +relationship: occurs_in GO:0098794 ! postsynapse +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:25:04Z + +[Term] +id: GO:0140250 +name: regulation protein catabolic process at synapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0009894 ! regulation of catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: has_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0045202 ! synapse +intersection_of: regulates GO:0009056 ! catabolic process +relationship: has_input CHEBI:36080 ! protein +relationship: in_taxon NCBITaxon:33208 ! Metazoa +relationship: occurs_in GO:0045202 ! synapse +relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:34:56Z + +[Term] +id: GO:0140251 +name: regulation protein catabolic process at presynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140250 ! regulation protein catabolic process at synapse +intersection_of: GO:0065007 ! biological regulation +intersection_of: has_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0098793 ! presynapse +intersection_of: regulates GO:0009056 ! catabolic process +relationship: occurs_in GO:0098793 ! presynapse +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:35:39Z + +[Term] +id: GO:0140252 +name: regulation protein catabolic process at postsynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140250 ! regulation protein catabolic process at synapse +intersection_of: GO:0065007 ! biological regulation +intersection_of: has_input CHEBI:36080 ! protein +intersection_of: occurs_in GO:0098794 ! postsynapse +intersection_of: regulates GO:0009056 ! catabolic process +relationship: occurs_in GO:0098794 ! postsynapse +property_value: IAO:0000233 https://github.com/geneontology/synapse/issues/204 xsd:anyURI +created_by: pg +creation_date: 2018-07-15T10:35:56Z + [Term] id: GO:0140253 name: cell-cell fusion @@ -93158,6 +128486,24 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/1 created_by: pg creation_date: 2018-11-28T12:48:20Z +[Term] +id: GO:0140318 +name: protein transporter activity +namespace: molecular_function +def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] +comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. +synonym: "protein carrier activity" RELATED [] +synonym: "protein transport chaperone" RELATED [] +xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" +xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" +is_a: GO:0005215 ! transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: has_primary_input PR:000000001 ! protein +relationship: has_primary_input PR:000000001 ! protein +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/17073 xsd:anyURI +created_by: pg +creation_date: 2019-04-01T10:41:38Z + [Term] id: GO:0140352 name: export from cell @@ -93183,9 +128529,9 @@ synonym: "lipid efflux" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0140352 ! export from cell intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: has_target_end_location GO:0005576 ! extracellular region intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure -intersection_of: transports_or_maintains_localization_of CHEBI:18059 ! lipid created_by: pg creation_date: 2019-05-22T11:33:07Z @@ -93198,9 +128544,9 @@ synonym: "lipid uptake" BROAD [] is_a: GO:0006869 ! lipid transport is_a: GO:0098657 ! import into cell intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:18059 ! lipid intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure intersection_of: has_target_start_location GO:0005576 ! extracellular region -intersection_of: transports_or_maintains_localization_of CHEBI:18059 ! lipid created_by: pg creation_date: 2019-05-22T11:38:15Z @@ -93273,13 +128619,36 @@ property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/2 created_by: pg creation_date: 2021-08-09T15:30:06Z +[Term] +id: GO:0140734 +name: ammonium excretion +namespace: biological_process +def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900] +synonym: "ammonia excretion" RELATED [] +is_a: GO:0007588 ! excretion +intersection_of: GO:0007588 ! excretion +intersection_of: has_primary_input CHEBI:28938 ! ammonium +relationship: has_primary_input CHEBI:28938 ! ammonium +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22368 xsd:anyURI +created_by: pg +creation_date: 2021-11-24T17:55:51Z + +[Term] +id: GO:0150005 +name: enzyme activator complex +namespace: cellular_component +def: "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active." [GOC:bhm, PMID:16244137, PMID:28710280] +is_a: GO:0032991 ! protein-containing complex +intersection_of: GO:0032991 ! protein-containing complex +intersection_of: capable_of GO:0008047 ! enzyme activator activity +relationship: capable_of GO:0008047 ! enzyme activator activity + [Term] id: GO:0150031 name: regulation of protein localization to lysosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061462 ! protein localization to lysosome relationship: regulates GO:0061462 ! protein localization to lysosome @@ -93291,7 +128660,6 @@ id: GO:0150032 name: positive regulation of protein localization to lysosome namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -93305,7 +128673,6 @@ id: GO:0150033 name: negative regulation of protein localization to lysosome namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0150031 ! regulation of protein localization to lysosome is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -93352,6 +128719,58 @@ is_a: GO:0048880 ! sensory system development created_by: bc creation_date: 2018-07-23T10:31:58Z +[Term] +id: GO:0150076 +name: neuroinflammatory response +namespace: biological_process +def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] +synonym: "nerve tissue inflammatory response" EXACT [] +synonym: "nervous tissue inflammatory response" EXACT [] +synonym: "neural tissue inflammatory response" EXACT [] +is_a: GO:0006954 ! inflammatory response +created_by: bc +creation_date: 2018-07-26T12:25:34Z + +[Term] +id: GO:0150077 +name: regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] +is_a: GO:0050727 ! regulation of inflammatory response +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0150076 ! neuroinflammatory response +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: regulates GO:0150076 ! neuroinflammatory response +created_by: bc +creation_date: 2018-07-26T12:32:18Z + +[Term] +id: GO:0150078 +name: positive regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc] +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0150077 ! regulation of neuroinflammatory response +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0150076 ! neuroinflammatory response +relationship: positively_regulates GO:0150076 ! neuroinflammatory response +created_by: bc +creation_date: 2018-07-26T12:35:50Z + +[Term] +id: GO:0150079 +name: negative regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423] +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0150077 ! regulation of neuroinflammatory response +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0150076 ! neuroinflammatory response +relationship: negatively_regulates GO:0150076 ! neuroinflammatory response +created_by: bc +creation_date: 2018-07-26T12:38:08Z + [Term] id: GO:0150098 name: glial cell-neuron signaling @@ -93458,6 +128877,18 @@ relationship: negatively_regulates GO:0034435 ! cholesterol esterification created_by: bc creation_date: 2019-07-23T15:34:42Z +[Term] +id: GO:0150111 +name: regulation of transepithelial transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] +is_a: GO:0051049 ! regulation of transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0070633 ! transepithelial transport +relationship: regulates GO:0070633 ! transepithelial transport +created_by: bc +creation_date: 2019-09-15T07:16:49Z + [Term] id: GO:0150119 name: negative regulation of protein localization to cell-cell junction @@ -93651,6 +129082,55 @@ relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmiss created_by: kmv creation_date: 2012-01-26T10:14:22Z +[Term] +id: GO:1900076 +name: regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0032869 ! cellular response to insulin stimulus +relationship: regulates GO:0032869 ! cellular response to insulin stimulus +created_by: yaf +creation_date: 2012-01-31T11:22:22Z + +[Term] +id: GO:1900077 +name: negative regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900076 ! regulation of cellular response to insulin stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0032869 ! cellular response to insulin stimulus +relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus +created_by: yaf +creation_date: 2012-01-31T11:23:15Z + +[Term] +id: GO:1900078 +name: positive regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900076 ! regulation of cellular response to insulin stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0032869 ! cellular response to insulin stimulus +relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus +created_by: yaf +creation_date: 2012-01-31T11:24:30Z + [Term] id: GO:1900115 name: extracellular regulation of signal transduction @@ -94022,6 +129502,29 @@ relationship: positively_regulates GO:0036135 ! Schwann cell migration created_by: bf creation_date: 2012-03-06T04:14:58Z +[Term] +id: GO:1900150 +name: regulation of defense response to fungus +namespace: biological_process +alt_id: GO:2000072 +def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006] +synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol] +synonym: "regulation of defense response to fungus, incompatible interaction" NARROW [] +synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol] +synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol] +synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0050832 ! defense response to fungus +relationship: regulates GO:0050832 ! defense response to fungus +created_by: dhl +creation_date: 2012-03-06T10:00:16Z + [Term] id: GO:1900157 name: regulation of bone mineralization involved in bone maturation @@ -94070,14 +129573,15 @@ creation_date: 2012-03-07T08:55:16Z [Term] id: GO:1900160 -name: plastid DNA packaging +name: plastid chromosome packaging namespace: biological_process -def: "Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] +def: "A process in which plastidial DNA and associated proteins organize into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] +synonym: "plastid DNA packaging" EXACT [] synonym: "plastidial DNA packaging" EXACT [GOC:emb] -is_a: GO:0036385 ! nucleoid DNA packaging -intersection_of: GO:0006323 ! DNA packaging +is_a: GO:0051276 ! chromosome organization +intersection_of: GO:0051276 ! chromosome organization intersection_of: occurs_in GO:0009536 ! plastid relationship: occurs_in GO:0009536 ! plastid property_value: RO:0002161 NCBITaxon:2 @@ -94098,7 +129602,6 @@ synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034504 ! protein localization to nucleus relationship: regulates GO:0034504 ! protein localization to nucleus @@ -94129,7 +129632,6 @@ synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -94162,7 +129664,6 @@ synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1900180 ! regulation of protein localization to nucleus is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -94171,6 +129672,55 @@ relationship: positively_regulates GO:0034504 ! protein localization to nucleus created_by: bf creation_date: 2012-03-12T01:23:52Z +[Term] +id: GO:1900193 +name: regulation of oocyte maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +is_a: GO:1903429 ! regulation of cell maturation +is_a: GO:2000241 ! regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0001556 ! oocyte maturation +relationship: regulates GO:0001556 ! oocyte maturation +created_by: kmv +creation_date: 2012-03-19T09:41:18Z + +[Term] +id: GO:1900194 +name: negative regulation of oocyte maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] +is_a: GO:1900193 ! regulation of oocyte maturation +is_a: GO:1903430 ! negative regulation of cell maturation +is_a: GO:2000242 ! negative regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0001556 ! oocyte maturation +relationship: negatively_regulates GO:0001556 ! oocyte maturation +created_by: kmv +creation_date: 2012-03-19T09:41:27Z + +[Term] +id: GO:1900195 +name: positive regulation of oocyte maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] +is_a: GO:1900193 ! regulation of oocyte maturation +is_a: GO:1903431 ! positive regulation of cell maturation +is_a: GO:2000243 ! positive regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0001556 ! oocyte maturation +relationship: positively_regulates GO:0001556 ! oocyte maturation +created_by: kmv +creation_date: 2012-03-19T09:41:35Z + [Term] id: GO:1900271 name: regulation of long-term synaptic potentiation @@ -94239,6 +129789,135 @@ relationship: positively_regulates GO:0060291 ! long-term synaptic potentiation created_by: rl creation_date: 2012-04-04T07:17:30Z +[Term] +id: GO:1900366 +name: negative regulation of defense response to insect +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] +synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie] +synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie] +synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "susceptibility to insect" RELATED [] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:2000068 ! regulation of defense response to insect +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002213 ! defense response to insect +relationship: negatively_regulates GO:0002213 ! defense response to insect +created_by: dhl +creation_date: 2012-04-12T04:44:00Z + +[Term] +id: GO:1900367 +name: positive regulation of defense response to insect +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] +synonym: "activation of defense response to insect" NARROW [GOC:TermGenie] +synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie] +synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:2000068 ! regulation of defense response to insect +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002213 ! defense response to insect +relationship: positively_regulates GO:0002213 ! defense response to insect +created_by: dhl +creation_date: 2012-04-12T04:44:10Z + +[Term] +id: GO:1900371 +name: regulation of purine nucleotide biosynthetic process +def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [] +synonym: "regulation of purine nucleotide anabolism" EXACT [] +synonym: "regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "regulation of purine nucleotide formation" EXACT [] +synonym: "regulation of purine nucleotide synthesis" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006164 ! purine nucleotide biosynthetic process +relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process + +[Term] +id: GO:1900372 +name: negative regulation of purine nucleotide biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [] +synonym: "down regulation of purine nucleotide anabolism" EXACT [] +synonym: "down regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "down regulation of purine nucleotide formation" EXACT [] +synonym: "down regulation of purine nucleotide synthesis" EXACT [] +synonym: "down-regulation of purine nucleotide anabolism" EXACT [] +synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of purine nucleotide formation" EXACT [] +synonym: "down-regulation of purine nucleotide synthesis" EXACT [] +synonym: "downregulation of purine nucleotide anabolism" EXACT [] +synonym: "downregulation of purine nucleotide biosynthesis" EXACT [] +synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of purine nucleotide formation" EXACT [] +synonym: "downregulation of purine nucleotide synthesis" EXACT [] +synonym: "inhibition of purine nucleotide anabolism" EXACT [] +synonym: "inhibition of purine nucleotide biosynthesis" EXACT [] +synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [] +synonym: "inhibition of purine nucleotide formation" EXACT [] +synonym: "inhibition of purine nucleotide synthesis" EXACT [] +synonym: "negative regulation of purine nucleotide anabolism" EXACT [] +synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of purine nucleotide formation" EXACT [] +synonym: "negative regulation of purine nucleotide synthesis" EXACT [] +is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process +relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process + +[Term] +id: GO:1900373 +name: positive regulation of purine nucleotide biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [] +synonym: "activation of purine nucleotide anabolism" EXACT [] +synonym: "activation of purine nucleotide biosynthesis" EXACT [] +synonym: "activation of purine nucleotide biosynthetic process" NARROW [] +synonym: "activation of purine nucleotide formation" EXACT [] +synonym: "activation of purine nucleotide synthesis" EXACT [] +synonym: "positive regulation of purine nucleotide anabolism" EXACT [] +synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of purine nucleotide formation" EXACT [] +synonym: "positive regulation of purine nucleotide synthesis" EXACT [] +synonym: "up regulation of purine nucleotide anabolism" EXACT [] +synonym: "up regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "up regulation of purine nucleotide formation" EXACT [] +synonym: "up regulation of purine nucleotide synthesis" EXACT [] +synonym: "up-regulation of purine nucleotide anabolism" EXACT [] +synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [] +synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of purine nucleotide formation" EXACT [] +synonym: "up-regulation of purine nucleotide synthesis" EXACT [] +synonym: "upregulation of purine nucleotide anabolism" EXACT [] +synonym: "upregulation of purine nucleotide biosynthesis" EXACT [] +synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of purine nucleotide formation" EXACT [] +synonym: "upregulation of purine nucleotide synthesis" EXACT [] +is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process +relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process + [Term] id: GO:1900376 name: regulation of secondary metabolite biosynthetic process @@ -94297,6 +129976,122 @@ relationship: positively_regulates GO:0044550 ! secondary metabolite biosyntheti created_by: di creation_date: 2012-04-17T01:55:41Z +[Term] +id: GO:1900424 +name: regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902477 +def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to bacterium, incompatible interaction" NARROW [] +synonym: "regulation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "regulation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0042742 ! defense response to bacterium +relationship: regulates GO:0042742 ! defense response to bacterium +created_by: dhl +creation_date: 2012-04-24T10:12:43Z + +[Term] +id: GO:1900425 +name: negative regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902478 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie] +synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie] +synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie] +synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "negative regulation of defense response to bacterium, incompatible interaction" NARROW [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1900424 ! regulation of defense response to bacterium +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0042742 ! defense response to bacterium +relationship: negatively_regulates GO:0042742 ! defense response to bacterium +created_by: dhl +creation_date: 2012-04-24T10:12:54Z + +[Term] +id: GO:1900426 +name: positive regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902479 +def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie] +synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of defense response to bacterium, incompatible interaction" NARROW [] +synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1900424 ! regulation of defense response to bacterium +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0042742 ! defense response to bacterium +relationship: positively_regulates GO:0042742 ! defense response to bacterium +created_by: dhl +creation_date: 2012-04-24T10:13:13Z + [Term] id: GO:1900449 name: regulation of glutamate receptor signaling pathway @@ -94615,6 +130410,7 @@ def: "The chemical reactions and pathways involving carbohydrate derivative." [G subset: goslim_agr subset: goslim_generic subset: goslim_mouse +subset: prokaryote_subset synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process intersection_of: GO:0008152 ! metabolic process @@ -94623,6 +130419,22 @@ relationship: has_primary_input_or_output CHEBI:63299 ! carbohydrate derivative created_by: bf creation_date: 2012-07-12T04:05:09Z +[Term] +id: GO:1901136 +name: carbohydrate derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] +synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] +is_a: GO:1901135 ! carbohydrate derivative metabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative +relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative +created_by: bf +creation_date: 2012-07-12T04:05:31Z + [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process @@ -94640,6 +130452,36 @@ relationship: has_primary_output CHEBI:63299 ! carbohydrate derivative created_by: bf creation_date: 2012-07-12T04:05:39Z +[Term] +id: GO:1901142 +name: insulin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie] +synonym: "insulin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019538 ! protein metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: has_primary_input_or_output PR:000009054 ! insulin gene translation product +relationship: has_primary_input_or_output PR:000009054 ! insulin gene translation product +property_value: RO:0002161 NCBITaxon:33090 +created_by: pm +creation_date: 2012-07-13T12:32:40Z + +[Term] +id: GO:1901143 +name: insulin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie] +synonym: "insulin breakdown" EXACT [GOC:TermGenie] +synonym: "insulin catabolism" EXACT [GOC:TermGenie] +synonym: "insulin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:1901142 ! insulin metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input PR:000009054 ! insulin gene translation product +relationship: has_primary_input PR:000009054 ! insulin gene translation product +created_by: pm +creation_date: 2012-07-13T12:33:03Z + [Term] id: GO:1901148 name: gene expression involved in extracellular matrix organization @@ -94667,6 +130509,22 @@ relationship: has_primary_input_or_output CHEBI:50994 ! primary amino compound created_by: bf creation_date: 2012-07-18T04:44:39Z +[Term] +id: GO:1901161 +name: primary amino compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] +synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] +synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] +synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901160 ! primary amino compound metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:50994 ! primary amino compound +relationship: has_primary_input CHEBI:50994 ! primary amino compound +created_by: bf +creation_date: 2012-07-18T04:45:06Z + [Term] id: GO:1901162 name: primary amino compound biosynthetic process @@ -94684,6 +130542,58 @@ relationship: has_primary_output CHEBI:50994 ! primary amino compound created_by: bf creation_date: 2012-07-18T04:45:14Z +[Term] +id: GO:1901163 +name: regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:2000241 ! regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0061450 ! trophoblast cell migration +relationship: regulates GO:0061450 ! trophoblast cell migration +created_by: vk +creation_date: 2012-07-19T07:53:06Z + +[Term] +id: GO:1901164 +name: negative regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901163 ! regulation of trophoblast cell migration +is_a: GO:2000242 ! negative regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0061450 ! trophoblast cell migration +relationship: negatively_regulates GO:0061450 ! trophoblast cell migration +created_by: vk +creation_date: 2012-07-19T07:53:28Z + +[Term] +id: GO:1901165 +name: positive regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901163 ! regulation of trophoblast cell migration +is_a: GO:2000243 ! positive regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0061450 ! trophoblast cell migration +relationship: positively_regulates GO:0061450 ! trophoblast cell migration +created_by: vk +creation_date: 2012-07-19T07:53:35Z + [Term] id: GO:1901166 name: neural crest cell migration involved in autonomic nervous system development @@ -95098,11 +131008,23 @@ namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:63299 ! carbohydrate derivative -relationship: transports_or_maintains_localization_of CHEBI:63299 ! carbohydrate derivative +intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative +relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative created_by: bf creation_date: 2012-08-16T14:51:22Z +[Term] +id: GO:1901293 +name: nucleoside phosphate biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [] +synonym: "nucleoside phosphate anabolism" EXACT [] +synonym: "nucleoside phosphate biosynthesis" EXACT [] +synonym: "nucleoside phosphate formation" EXACT [] +synonym: "nucleoside phosphate synthesis" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + [Term] id: GO:1901317 name: regulation of flagellated sperm motility @@ -95215,6 +131137,22 @@ relationship: has_primary_input_or_output CHEBI:33832 ! organic cyclic compound created_by: bf creation_date: 2012-09-14T09:03:51Z +[Term] +id: GO:1901361 +name: organic cyclic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie] +synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33832 ! organic cyclic compound +relationship: has_primary_input CHEBI:33832 ! organic cyclic compound +created_by: bf +creation_date: 2012-09-14T09:05:04Z + [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process @@ -95251,11 +131189,70 @@ namespace: biological_process def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] is_a: GO:0071702 ! organic substance transport intersection_of: GO:0006810 ! transport -intersection_of: transports_or_maintains_localization_of CHEBI:47622 ! acetate ester -relationship: transports_or_maintains_localization_of CHEBI:47622 ! acetate ester +intersection_of: has_primary_input CHEBI:47622 ! acetate ester +relationship: has_primary_input CHEBI:47622 ! acetate ester created_by: bf creation_date: 2012-09-28T10:42:13Z +[Term] +id: GO:1901375 +name: acetate ester transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:47622 ! acetate ester +relationship: has_primary_input CHEBI:47622 ! acetate ester +relationship: part_of GO:1901374 ! acetate ester transport +created_by: bf +creation_date: 2012-09-28T10:47:08Z + +[Term] +id: GO:1901382 +name: regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +is_a: GO:0042127 ! regulation of cell population proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0097360 ! chorionic trophoblast cell proliferation +relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation +created_by: vk +creation_date: 2012-10-01T10:03:13Z + +[Term] +id: GO:1901383 +name: negative regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation +relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation +created_by: vk +creation_date: 2012-10-01T10:04:23Z + +[Term] +id: GO:1901384 +name: positive regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation +relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation +created_by: vk +creation_date: 2012-10-01T10:04:41Z + [Term] id: GO:1901401 name: regulation of tetrapyrrole metabolic process @@ -95316,6 +131313,181 @@ relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process created_by: tt creation_date: 2012-10-01T14:35:29Z +[Term] +id: GO:1901404 +name: regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0033015 ! tetrapyrrole catabolic process +relationship: regulates GO:0033015 ! tetrapyrrole catabolic process +created_by: tt +creation_date: 2012-10-01T14:38:12Z + +[Term] +id: GO:1901405 +name: negative regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process +is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process +relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process +created_by: tt +creation_date: 2012-10-01T14:39:22Z + +[Term] +id: GO:1901406 +name: positive regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process +is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0033015 ! tetrapyrrole catabolic process +relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process +created_by: tt +creation_date: 2012-10-01T14:39:40Z + +[Term] +id: GO:1901410 +name: regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +is_a: GO:2000211 ! regulation of glutamate metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +relationship: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +created_by: tt +creation_date: 2012-10-01T16:20:56Z + +[Term] +id: GO:1901411 +name: negative regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate +is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process +is_a: GO:2000212 ! negative regulation of glutamate metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +relationship: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +created_by: tt +creation_date: 2012-10-01T16:22:03Z + +[Term] +id: GO:1901412 +name: positive regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate +is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process +is_a: GO:2000213 ! positive regulation of glutamate metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +relationship: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate +created_by: tt +creation_date: 2012-10-01T16:22:21Z + [Term] id: GO:1901419 name: regulation of response to alcohol @@ -95618,6 +131790,20 @@ relationship: positively_regulates GO:0006534 ! cysteine metabolic process created_by: vw creation_date: 2012-10-16T14:28:51Z +[Term] +id: GO:1901505 +name: carbohydrate derivative transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "carbohydrate derivative transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative +relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative +relationship: part_of GO:1901264 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! carbohydrate derivative transport +created_by: pr +creation_date: 2012-10-17T10:31:22Z + [Term] id: GO:1901509 name: regulation of endothelial tube morphogenesis @@ -95771,6 +131957,22 @@ relationship: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound created_by: pr creation_date: 2012-11-04T15:17:52Z +[Term] +id: GO:1901565 +name: organonitrogen compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie] +synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901575 ! organic substance catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:35352 ! organonitrogen compound +relationship: has_primary_input CHEBI:35352 ! organonitrogen compound +created_by: pr +creation_date: 2012-11-04T15:17:56Z + [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process @@ -95794,7 +131996,7 @@ name: fatty acid derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie] synonym: "fatty acid derivative metabolism" EXACT [GOC:TermGenie] -is_a: GO:0071704 ! organic substance metabolic process +is_a: GO:0006629 ! lipid metabolic process created_by: pr creation_date: 2012-11-04T17:13:36Z @@ -95807,8 +132009,8 @@ synonym: "fatty acid derivative anabolism" EXACT [GOC:TermGenie] synonym: "fatty acid derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "fatty acid derivative formation" EXACT [GOC:TermGenie] synonym: "fatty acid derivative synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1901568 ! fatty acid derivative metabolic process -is_a: GO:1901576 ! organic substance biosynthetic process created_by: pr creation_date: 2012-11-04T17:13:44Z @@ -95826,6 +132028,9 @@ synonym: "organic substance catabolism" EXACT [] synonym: "organic substance degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0071704 ! organic substance metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity +relationship: has_primary_input CHEBI:50860 ! organic molecular entity created_by: pr creation_date: 2012-11-05T11:04:36Z @@ -95897,6 +132102,23 @@ relationship: has_primary_input_or_output CHEBI:33704 ! alpha-amino acid created_by: tb creation_date: 2012-11-08T17:39:50Z +[Term] +id: GO:1901606 +name: alpha-amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] +synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33704 ! alpha-amino acid +relationship: has_primary_input CHEBI:33704 ! alpha-amino acid +created_by: tb +creation_date: 2012-11-08T17:39:54Z + [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process @@ -95986,6 +132208,22 @@ relationship: has_primary_input_or_output CHEBI:33822 ! organic hydroxy compound created_by: pr creation_date: 2012-11-13T12:54:27Z +[Term] +id: GO:1901616 +name: organic hydroxy compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie] +synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901575 ! organic substance catabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound +relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound +created_by: pr +creation_date: 2012-11-13T12:54:31Z + [Term] id: GO:1901617 name: organic hydroxy compound biosynthetic process @@ -96003,6 +132241,18 @@ relationship: has_primary_output CHEBI:33822 ! organic hydroxy compound created_by: pr creation_date: 2012-11-13T12:54:36Z +[Term] +id: GO:1901618 +name: organic hydroxy compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound +relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound +created_by: pr +creation_date: 2012-11-13T12:59:01Z + [Term] id: GO:1901623 name: regulation of lymphocyte chemotaxis @@ -96173,6 +132423,19 @@ relationship: has_input CHEBI:26835 ! sulfur molecular entity created_by: pr creation_date: 2012-11-26T20:45:23Z +[Term] +id: GO:1901682 +name: sulfur compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "sulfur molecular entity transmembrane transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity +relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity +created_by: pr +creation_date: 2012-11-26T20:45:29Z + [Term] id: GO:1901692 name: regulation of compound eye retinal cell apoptotic process @@ -96274,6 +132537,18 @@ intersection_of: has_input CHEBI:25806 ! oxygen molecular entity created_by: pr creation_date: 2012-12-13T15:11:42Z +[Term] +id: GO:1901702 +name: salt transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: has_primary_input CHEBI:24866 ! salt +relationship: has_primary_input CHEBI:24866 ! salt +created_by: pr +creation_date: 2012-12-13T15:14:47Z + [Term] id: GO:1901706 name: mesenchymal cell differentiation involved in bone development @@ -97129,6 +133404,32 @@ relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differen created_by: ss creation_date: 2013-04-02T05:19:19Z +[Term] +id: GO:1902074 +name: response to salt +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] +synonym: "response to salinity" NARROW [GOC:mls] +is_a: GO:0042221 ! response to chemical +intersection_of: GO:0050896 ! response to stimulus +intersection_of: has_input CHEBI:24866 ! salt +relationship: has_input CHEBI:24866 ! salt +created_by: mls +creation_date: 2013-04-22T15:41:57Z + +[Term] +id: GO:1902075 +name: cellular response to salt +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] +synonym: "cellular response to salinity" NARROW [GOC:mls] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1902074 ! response to salt +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:24866 ! salt +created_by: mls +creation_date: 2013-04-22T15:42:02Z + [Term] id: GO:1902093 name: positive regulation of flagellated sperm motility @@ -97691,8 +133992,11 @@ creation_date: 2013-06-25T16:16:00Z id: GO:1902275 name: regulation of chromatin organization namespace: biological_process +alt_id: GO:0001672 alt_id: GO:1903308 def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] +synonym: "regulation of chromatin assembly or disassembly" RELATED [] +synonym: "regulation of chromatin assembly/disassembly" RELATED [] synonym: "regulation of chromatin modification" RELATED [] synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] @@ -97739,6 +134043,66 @@ relationship: part_of GO:0097485 ! neuron projection guidance created_by: pr creation_date: 2013-07-08T15:55:17Z +[Term] +id: GO:1902305 +name: regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035725 ! sodium ion transmembrane transport +relationship: regulates GO:0035725 ! sodium ion transmembrane transport +created_by: rl +creation_date: 2013-07-18T13:33:53Z + +[Term] +id: GO:1902306 +name: negative regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0010766 ! negative regulation of sodium ion transport +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035725 ! sodium ion transmembrane transport +relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport +created_by: rl +creation_date: 2013-07-18T13:34:01Z + +[Term] +id: GO:1902307 +name: positive regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0010765 ! positive regulation of sodium ion transport +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035725 ! sodium ion transmembrane transport +relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport +created_by: rl +creation_date: 2013-07-18T13:34:18Z + [Term] id: GO:1902337 name: regulation of apoptotic process involved in morphogenesis @@ -97845,6 +134209,18 @@ relationship: negatively_regulates GO:0030261 ! chromosome condensation created_by: dgf creation_date: 2013-07-29T20:54:14Z +[Term] +id: GO:1902358 +name: sulfate transmembrane transport +namespace: biological_process +def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] +is_a: GO:0008272 ! sulfate transport +is_a: GO:0098661 ! inorganic anion transmembrane transport +intersection_of: GO:0055085 ! transmembrane transport +intersection_of: has_primary_input CHEBI:16189 ! sulfate +created_by: dph +creation_date: 2013-08-14T14:46:04Z + [Term] id: GO:1902362 name: melanocyte apoptotic process @@ -97860,6 +134236,38 @@ relationship: occurs_in CL:0000148 ! melanocyte created_by: pr creation_date: 2013-08-15T16:35:45Z +[Term] +id: GO:1902369 +name: negative regulation of RNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] +synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0051253 ! negative regulation of RNA metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006401 ! RNA catabolic process +relationship: negatively_regulates GO:0006401 ! RNA catabolic process +created_by: bf +creation_date: 2013-08-22T14:59:39Z + [Term] id: GO:1902414 name: protein localization to cell junction @@ -97883,7 +134291,7 @@ def: "A process in which a protein is transported to, or maintained in, a locati synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] -is_a: GO:0034613 ! cellular protein localization +is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0031252 ! cell leading edge relationship: has_target_end_location GO:0031252 ! cell leading edge @@ -97925,6 +134333,46 @@ relationship: positively_regulates GO:0035418 ! protein localization to synapse created_by: kmv creation_date: 2013-10-25T15:09:18Z +[Term] +id: GO:1902475 +name: L-alpha-amino acid transmembrane transport +namespace: biological_process +def: "The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347] +is_a: GO:0003333 ! amino acid transmembrane transport +intersection_of: GO:0055085 ! transmembrane transport +intersection_of: has_primary_input CHEBI:15705 ! L-alpha-amino acid +relationship: has_primary_input CHEBI:15705 ! L-alpha-amino acid +created_by: kmv +creation_date: 2013-10-25T15:17:39Z + +[Term] +id: GO:1902488 +name: cholangiocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800] +synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904019 ! epithelial cell apoptotic process +intersection_of: GO:0006915 ! apoptotic process +intersection_of: occurs_in CL:1000488 ! cholangiocyte +relationship: occurs_in CL:1000488 ! cholangiocyte +created_by: cls +creation_date: 2013-11-12T15:30:08Z + +[Term] +id: GO:1902489 +name: hepatoblast apoptotic process +namespace: biological_process +def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967] +synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process +intersection_of: GO:0006915 ! apoptotic process +intersection_of: occurs_in CL:0005026 ! hepatoblast +relationship: occurs_in CL:0005026 ! hepatoblast +created_by: cls +creation_date: 2013-11-12T17:02:52Z + [Term] id: GO:1902490 name: regulation of sperm capacitation @@ -98002,6 +134450,20 @@ relationship: capable_of GO:0003824 ! catalytic activity created_by: bhm creation_date: 2013-11-13T16:18:47Z +[Term] +id: GO:1902495 +name: transmembrane transporter complex +namespace: cellular_component +def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1990351 ! transporter complex +intersection_of: GO:0032991 ! protein-containing complex +intersection_of: capable_of GO:0022857 ! transmembrane transporter activity +relationship: capable_of GO:0022857 ! transmembrane transporter activity +relationship: part_of GO:0016021 ! integral component of membrane +created_by: bhm +creation_date: 2013-11-13T16:23:04Z + [Term] id: GO:1902513 name: regulation of organelle transport along microtubule @@ -98440,6 +134902,7 @@ def: "Any process that modulates the frequency, rate or extent of axon guidance. synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0050920 ! regulation of chemotaxis is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation @@ -98472,6 +134935,7 @@ synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie] synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0010977 ! negative regulation of neuron projection development is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:0051271 ! negative regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance @@ -98505,6 +134969,7 @@ synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie] synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie] synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie] synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0010976 ! positive regulation of neuron projection development is_a: GO:0051272 ! positive regulation of cellular component movement is_a: GO:1902667 ! regulation of axon guidance intersection_of: GO:0065007 ! biological regulation @@ -98660,6 +135125,25 @@ relationship: regulates GO:0007405 ! neuroblast proliferation created_by: rl creation_date: 2014-02-18T10:03:31Z +[Term] +id: GO:1902706 +name: hexose catabolic process to acetate +namespace: biological_process +alt_id: GO:1990286 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "acidogenesis" BROAD [GOC:tt] +synonym: "hexose breakdown to acetate" EXACT [GOC:TermGenie] +synonym: "hexose catabolism to acetate" EXACT [GOC:TermGenie] +synonym: "hexose degradation to acetate" EXACT [GOC:TermGenie] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0019320 ! hexose catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18133 ! hexose +intersection_of: has_primary_output CHEBI:30089 ! acetate +relationship: has_primary_output CHEBI:30089 ! acetate +created_by: tb +creation_date: 2014-02-19T18:43:23Z + [Term] id: GO:1902721 name: negative regulation of prolactin secretion @@ -98964,7 +135448,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035372 ! protein localization to microtubule relationship: regulates GO:0035372 ! protein localization to microtubule @@ -98985,7 +135468,6 @@ synonym: "downregulation of protein localization to microtubule" EXACT [GOC:Term synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1902816 ! regulation of protein localization to microtubule is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -99442,6 +135924,19 @@ relationship: positively_regulates GO:0032402 ! melanosome transport created_by: als creation_date: 2014-04-17T11:40:34Z +[Term] +id: GO:1902911 +name: protein kinase complex +namespace: cellular_component +def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] +comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +intersection_of: GO:0032991 ! protein-containing complex +intersection_of: capable_of GO:0004672 ! protein kinase activity +relationship: capable_of GO:0004672 ! protein kinase activity +created_by: bhm +creation_date: 2014-04-17T13:52:40Z + [Term] id: GO:1902913 name: positive regulation of neuroepithelial cell differentiation @@ -99735,6 +136230,7 @@ is_a: GO:0022402 ! cell cycle process is_a: GO:0022414 ! reproductive process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle +disjoint_from: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle created_by: jl creation_date: 2014-05-22T14:22:28Z @@ -100004,7 +136500,6 @@ name: regulation of actin filament-based movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] is_a: GO:0032970 ! regulation of actin filament-based process -is_a: GO:0051270 ! regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030048 ! actin filament-based movement relationship: regulates GO:0030048 ! actin filament-based movement @@ -100020,7 +136515,7 @@ synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] -is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903115 ! regulation of actin filament-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030048 ! actin filament-based movement @@ -100043,6 +136538,22 @@ relationship: has_target_end_location GO:0015629 ! actin cytoskeleton created_by: mah creation_date: 2014-06-16T11:27:09Z +[Term] +id: GO:1903120 +name: protein localization to actin filament bundle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] +synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localization to actin cable" RELATED [GOC:mah] +is_a: GO:1903119 ! protein localization to actin cytoskeleton +intersection_of: GO:0008104 ! protein localization +intersection_of: has_target_end_location GO:0032432 ! actin filament bundle +relationship: has_target_end_location GO:0032432 ! actin filament bundle +created_by: mah +creation_date: 2014-06-16T11:27:16Z + [Term] id: GO:1903131 name: mononuclear cell differentiation @@ -100401,6 +136912,19 @@ relationship: positively_regulates GO:0050901 ! leukocyte tethering or rolling created_by: als creation_date: 2014-07-31T13:08:01Z +[Term] +id: GO:1903251 +name: multi-ciliated epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224] +synonym: "multiciliate cell differentiation" BROAD [] +is_a: GO:0030855 ! epithelial cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: results_in_acquisition_of_features_of CL:0005012 ! multi-ciliated epithelial cell +relationship: results_in_acquisition_of_features_of CL:0005012 ! multi-ciliated epithelial cell +created_by: tb +creation_date: 2014-08-05T19:21:21Z + [Term] id: GO:1903282 name: regulation of glutathione peroxidase activity @@ -100871,6 +137395,55 @@ relationship: positively_regulates GO:0045055 ! regulated exocytosis created_by: pad creation_date: 2014-08-18T10:05:10Z +[Term] +id: GO:1903317 +name: regulation of protein maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051246 ! regulation of protein metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051604 ! protein maturation +relationship: regulates GO:0051604 ! protein maturation +created_by: vw +creation_date: 2014-08-18T12:59:07Z + +[Term] +id: GO:1903318 +name: negative regulation of protein maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1903317 ! regulation of protein maturation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051604 ! protein maturation +relationship: negatively_regulates GO:0051604 ! protein maturation +created_by: vw +creation_date: 2014-08-18T12:59:15Z + +[Term] +id: GO:1903319 +name: positive regulation of protein maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of protein maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1903317 ! regulation of protein maturation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051604 ! protein maturation +relationship: positively_regulates GO:0051604 ! protein maturation +created_by: vw +creation_date: 2014-08-18T12:59:23Z + [Term] id: GO:1903335 name: regulation of vacuolar transport @@ -100972,22 +137545,6 @@ relationship: regulates GO:0007030 ! Golgi organization created_by: als creation_date: 2014-08-21T10:22:22Z -[Term] -id: GO:1903374 -name: subarachnoid space development -namespace: biological_process -def: "The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure." [GO_REF:0000094, GOC:cjm, GOC:TermGenie, Wikipedia:Subarachnoid_space] -synonym: "cavitas subarachnoidea development" RELATED [GOC:TermGenie] -synonym: "cavum subarachnoideale development" RELATED [GOC:TermGenie] -synonym: "spatium leptomeningeum development" RELATED [GOC:TermGenie] -synonym: "spatium subarachnoideum development" RELATED [GOC:TermGenie] -synonym: "subarachnoid cavity development" RELATED [GOC:TermGenie] -is_a: GO:0048856 ! anatomical structure development -relationship: part_of GO:0007417 ! central nervous system development -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/21883 xsd:anyURI -created_by: pr -creation_date: 2014-08-22T12:20:56Z - [Term] id: GO:1903379 name: regulation of mitotic chromosome condensation @@ -101021,6 +137578,34 @@ relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation created_by: al creation_date: 2014-08-26T13:57:29Z +[Term] +id: GO:1903412 +name: response to bile acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound +intersection_of: GO:0050896 ! response to stimulus +intersection_of: has_input CHEBI:3098 ! bile acid +relationship: has_input CHEBI:3098 ! bile acid +created_by: rl +creation_date: 2014-09-03T12:45:43Z + +[Term] +id: GO:1903413 +name: cellular response to bile acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1903412 ! response to bile acid +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:3098 ! bile acid +created_by: rl +creation_date: 2014-09-03T12:45:51Z + [Term] id: GO:1903429 name: regulation of cell maturation @@ -101299,6 +137884,35 @@ relationship: positively_regulates GO:0032940 ! secretion by cell created_by: pm creation_date: 2014-10-08T13:25:17Z +[Term] +id: GO:1903537 +name: meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] +synonym: "meiosis involved in oocyte maturation" BROAD [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:1903046 ! meiotic cell cycle process +intersection_of: GO:1903046 ! meiotic cell cycle process +intersection_of: part_of GO:0001556 ! oocyte maturation +relationship: part_of GO:0001556 ! oocyte maturation +created_by: pr +creation_date: 2014-10-09T10:46:14Z + +[Term] +id: GO:1903538 +name: regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] +synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051726 ! regulation of cell cycle +is_a: GO:2000241 ! regulation of reproductive process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +created_by: pr +creation_date: 2014-10-09T10:52:38Z + [Term] id: GO:1903539 name: protein localization to postsynaptic membrane @@ -101491,7 +138105,6 @@ name: regulation of protein localization to cilium namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061512 ! protein localization to cilium relationship: regulates GO:0061512 ! protein localization to cilium @@ -101507,7 +138120,6 @@ synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGeni synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903828 ! negative regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -101525,7 +138137,6 @@ synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903564 ! regulation of protein localization to cilium is_a: GO:1903829 ! positive regulation of protein localization intersection_of: GO:0065007 ! biological regulation @@ -101625,7 +138236,7 @@ name: regulation of ATP metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie] -is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0046034 ! ATP metabolic process relationship: regulates GO:0046034 ! ATP metabolic process @@ -101646,7 +138257,7 @@ synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie] -is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0046034 ! ATP metabolic process @@ -101668,7 +138279,7 @@ synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie] -is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0046034 ! ATP metabolic process @@ -101733,6 +138344,50 @@ relationship: positively_regulates GO:0016482 ! cytosolic transport created_by: jl creation_date: 2014-11-24T13:38:34Z +[Term] +id: GO:1903697 +name: negative regulation of microvillus assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] +synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0032534 ! regulation of microvillus assembly +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0030033 ! microvillus assembly +relationship: negatively_regulates GO:0030033 ! microvillus assembly +created_by: als +creation_date: 2014-12-03T11:45:08Z + +[Term] +id: GO:1903698 +name: positive regulation of microvillus assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] +synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] +synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0032534 ! regulation of microvillus assembly +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0030033 ! microvillus assembly +relationship: positively_regulates GO:0030033 ! microvillus assembly +created_by: als +creation_date: 2014-12-03T11:45:17Z + [Term] id: GO:1903699 name: tarsal gland development @@ -101903,8 +138558,10 @@ synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie] synonym: "set of uterine glands development" RELATED [GOC:TermGenie] synonym: "uterine glands development" EXACT [GOC:TermGenie] synonym: "uterine glands set development" EXACT [GOC:TermGenie] -is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0002451 ! endometrial gland +relationship: results_in_development_of UBERON:0002451 ! endometrial gland created_by: cls creation_date: 2014-12-04T18:57:21Z @@ -102011,6 +138668,20 @@ relationship: positively_regulates GO:0061337 ! cardiac conduction created_by: rph creation_date: 2015-01-07T13:20:28Z +[Term] +id: GO:1903789 +name: regulation of amino acid transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] +synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0051955 ! regulation of amino acid transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0003333 ! amino acid transmembrane transport +relationship: regulates GO:0003333 ! amino acid transmembrane transport +created_by: al +creation_date: 2015-01-08T17:42:18Z + [Term] id: GO:1903792 name: negative regulation of anion transport @@ -102045,6 +138716,87 @@ relationship: positively_regulates GO:0006820 ! anion transport created_by: sl creation_date: 2015-01-12T21:50:30Z +[Term] +id: GO:1903795 +name: regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903959 ! regulation of anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098661 ! inorganic anion transmembrane transport +relationship: regulates GO:0098661 ! inorganic anion transmembrane transport +created_by: sl +creation_date: 2015-01-14T21:44:49Z + +[Term] +id: GO:1903796 +name: negative regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport +relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport +created_by: sl +creation_date: 2015-01-14T21:44:59Z + +[Term] +id: GO:1903797 +name: positive regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098661 ! inorganic anion transmembrane transport +relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport +created_by: sl +creation_date: 2015-01-14T21:45:08Z + +[Term] +id: GO:1903825 +name: organic acid transmembrane transport +namespace: biological_process +def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] +is_a: GO:0015849 ! organic acid transport +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:64709 ! organic acid +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: vw +creation_date: 2015-01-20T10:20:58Z + [Term] id: GO:1903828 name: negative regulation of protein localization @@ -102061,7 +138813,7 @@ synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein localization" EXACT [] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008104 ! protein localization relationship: negatively_regulates GO:0008104 ! protein localization @@ -102083,7 +138835,7 @@ synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008104 ! protein localization relationship: positively_regulates GO:0008104 ! protein localization @@ -102153,6 +138905,150 @@ relationship: positively_regulates GO:0035909 ! aorta morphogenesis created_by: rph creation_date: 2015-01-23T14:01:09Z +[Term] +id: GO:1903862 +name: positive regulation of oxidative phosphorylation +def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [] +synonym: "activation of oxidative phosphorylation" NARROW [] +synonym: "activation of respiratory-chain phosphorylation" NARROW [] +synonym: "positive regulation of respiratory-chain phosphorylation" EXACT [] +synonym: "up regulation of oxidative phosphorylation" EXACT [] +synonym: "up regulation of respiratory-chain phosphorylation" EXACT [] +synonym: "up-regulation of oxidative phosphorylation" EXACT [] +synonym: "up-regulation of respiratory-chain phosphorylation" EXACT [] +synonym: "upregulation of oxidative phosphorylation" EXACT [] +synonym: "upregulation of respiratory-chain phosphorylation" EXACT [] +is_a: GO:0002082 ! regulation of oxidative phosphorylation +is_a: GO:1901857 ! positive regulation of cellular respiration +is_a: GO:1903580 ! positive regulation of ATP metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006119 ! oxidative phosphorylation +relationship: positively_regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:1903867 +name: extraembryonic membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] +is_a: GO:0048856 ! anatomical structure development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0005631 ! extraembryonic membrane +relationship: results_in_development_of UBERON:0005631 ! extraembryonic membrane +created_by: cjm +creation_date: 2015-02-05T00:42:16Z + +[Term] +id: GO:1903903 +name: regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:2000114 ! regulation of establishment of cell polarity +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0001768 ! establishment of T cell polarity +relationship: regulates GO:0001768 ! establishment of T cell polarity +created_by: als +creation_date: 2015-02-09T10:50:21Z + +[Term] +id: GO:1903904 +name: negative regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie] +synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie] +synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:0050868 ! negative regulation of T cell activation +is_a: GO:1903903 ! regulation of establishment of T cell polarity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0001768 ! establishment of T cell polarity +relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity +created_by: als +creation_date: 2015-02-09T10:50:30Z + +[Term] +id: GO:1903905 +name: positive regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "activation of T cell polarization" NARROW [GOC:TermGenie] +synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie] +synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:0050870 ! positive regulation of T cell activation +is_a: GO:1903903 ! regulation of establishment of T cell polarity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0001768 ! establishment of T cell polarity +relationship: positively_regulates GO:0001768 ! establishment of T cell polarity +created_by: als +creation_date: 2015-02-09T10:50:40Z + [Term] id: GO:1903941 name: negative regulation of respiratory gaseous exchange @@ -102187,6 +139083,63 @@ relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange by created_by: sl creation_date: 2015-02-17T20:26:35Z +[Term] +id: GO:1903943 +name: regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0097284 ! hepatocyte apoptotic process +relationship: regulates GO:0097284 ! hepatocyte apoptotic process +created_by: sl +creation_date: 2015-02-19T12:54:40Z + +[Term] +id: GO:1903944 +name: negative regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1903943 ! regulation of hepatocyte apoptotic process +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0097284 ! hepatocyte apoptotic process +relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process +created_by: sl +creation_date: 2015-02-19T12:54:50Z + +[Term] +id: GO:1903945 +name: positive regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1903943 ! regulation of hepatocyte apoptotic process +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0097284 ! hepatocyte apoptotic process +relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process +created_by: sl +creation_date: 2015-02-19T12:54:59Z + [Term] id: GO:1903950 name: negative regulation of AV node cell action potential @@ -102241,6 +139194,55 @@ relationship: positively_regulates GO:0086016 ! AV node cell action potential created_by: nc creation_date: 2015-02-20T14:59:50Z +[Term] +id: GO:1903959 +name: regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0044070 ! regulation of anion transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098656 ! anion transmembrane transport +relationship: regulates GO:0098656 ! anion transmembrane transport +created_by: pr +creation_date: 2015-02-25T13:52:25Z + +[Term] +id: GO:1903960 +name: negative regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:1903959 ! regulation of anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098656 ! anion transmembrane transport +relationship: negatively_regulates GO:0098656 ! anion transmembrane transport +created_by: pr +creation_date: 2015-02-25T13:52:35Z + +[Term] +id: GO:1903961 +name: positive regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:1903959 ! regulation of anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098656 ! anion transmembrane transport +relationship: positively_regulates GO:0098656 ! anion transmembrane transport +created_by: pr +creation_date: 2015-02-25T13:52:44Z + [Term] id: GO:1903975 name: regulation of glial cell migration @@ -102582,6 +139584,63 @@ relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic proces created_by: sl creation_date: 2015-03-13T22:05:53Z +[Term] +id: GO:1904054 +name: regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990705 ! cholangiocyte proliferation +relationship: regulates GO:1990705 ! cholangiocyte proliferation +created_by: sl +creation_date: 2015-03-18T17:56:14Z + +[Term] +id: GO:1904055 +name: negative regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:1904054 ! regulation of cholangiocyte proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990705 ! cholangiocyte proliferation +relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation +created_by: sl +creation_date: 2015-03-18T17:56:20Z + +[Term] +id: GO:1904056 +name: positive regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie] +synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:1904054 ! regulation of cholangiocyte proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990705 ! cholangiocyte proliferation +relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation +created_by: sl +creation_date: 2015-03-18T17:56:26Z + [Term] id: GO:1904057 name: negative regulation of sensory perception of pain @@ -102636,6 +139695,52 @@ relationship: positively_regulates GO:0019233 ! sensory perception of pain created_by: sl creation_date: 2015-03-18T20:34:03Z +[Term] +id: GO:1904062 +name: regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +is_a: GO:0034765 ! regulation of ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098655 ! cation transmembrane transport +relationship: regulates GO:0098655 ! cation transmembrane transport +created_by: sl +creation_date: 2015-03-18T21:11:43Z + +[Term] +id: GO:1904063 +name: negative regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098655 ! cation transmembrane transport +relationship: negatively_regulates GO:0098655 ! cation transmembrane transport +created_by: sl +creation_date: 2015-03-18T21:11:50Z + +[Term] +id: GO:1904064 +name: positive regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098655 ! cation transmembrane transport +relationship: positively_regulates GO:0098655 ! cation transmembrane transport +created_by: sl +creation_date: 2015-03-18T21:11:55Z + [Term] id: GO:1904065 name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission @@ -102781,6 +139886,21 @@ relationship: positively_regulates GO:0006493 ! protein O-linked glycosylation created_by: krc creation_date: 2015-03-27T16:10:10Z +[Term] +id: GO:1904106 +name: protein localization to microvillus +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] +synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] +synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] +synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] +is_a: GO:0008104 ! protein localization +intersection_of: GO:0008104 ! protein localization +intersection_of: has_target_end_location GO:0005902 ! microvillus +relationship: has_target_end_location GO:0005902 ! microvillus +created_by: kmv +creation_date: 2015-04-01T18:14:41Z + [Term] id: GO:1904113 name: negative regulation of muscle filament sliding @@ -102792,7 +139912,7 @@ synonym: "downregulation of muscle filament sliding" EXACT [GOC:TermGenie] synonym: "inhibition of muscle filament sliding" NARROW [GOC:TermGenie] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0045932 ! negative regulation of muscle contraction -is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030049 ! muscle filament sliding relationship: negatively_regulates GO:0030049 ! muscle filament sliding @@ -102826,6 +139946,7 @@ is_a: GO:0120111 ! neuron projection cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: part_of GO:0030424 ! axon relationship: part_of GO:0030424 ! axon +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/14472 xsd:anyURI created_by: sl creation_date: 2015-04-06T18:13:14Z @@ -102878,6 +139999,41 @@ relationship: positively_regulates GO:0071600 ! otic vesicle morphogenesis created_by: pga creation_date: 2015-04-07T14:01:08Z +[Term] +id: GO:1904145 +name: negative regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] +synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +is_a: GO:1900194 ! negative regulation of oocyte maturation +is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +created_by: tb +creation_date: 2015-04-14T15:59:22Z + +[Term] +id: GO:1904146 +name: positive regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] +synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation +created_by: tb +creation_date: 2015-04-14T15:59:28Z + [Term] id: GO:1904170 name: regulation of bleb assembly @@ -102994,6 +140150,85 @@ relationship: positively_regulates GO:0060612 ! adipose tissue development created_by: sl creation_date: 2015-04-29T20:01:13Z +[Term] +id: GO:1904192 +name: regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1902488 ! cholangiocyte apoptotic process +relationship: regulates GO:1902488 ! cholangiocyte apoptotic process +created_by: sl +creation_date: 2015-05-06T15:25:48Z + +[Term] +id: GO:1904193 +name: negative regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process +relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process +created_by: sl +creation_date: 2015-05-06T15:25:55Z + +[Term] +id: GO:1904194 +name: positive regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1902488 ! cholangiocyte apoptotic process +relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process +created_by: sl +creation_date: 2015-05-06T15:26:00Z + [Term] id: GO:1904204 name: regulation of skeletal muscle hypertrophy @@ -103043,6 +140278,144 @@ relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:25Z +[Term] +id: GO:1904251 +name: regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0008206 ! bile acid metabolic process +relationship: regulates GO:0008206 ! bile acid metabolic process +created_by: bf +creation_date: 2015-05-20T11:04:28Z + +[Term] +id: GO:1904252 +name: negative regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0008206 ! bile acid metabolic process +relationship: negatively_regulates GO:0008206 ! bile acid metabolic process +created_by: bf +creation_date: 2015-05-20T11:04:35Z + +[Term] +id: GO:1904253 +name: positive regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0008206 ! bile acid metabolic process +relationship: positively_regulates GO:0008206 ! bile acid metabolic process +created_by: bf +creation_date: 2015-05-20T11:04:40Z + +[Term] +id: GO:1904254 +name: regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of iron channel activity" EXACT [] +synonym: "regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0005381 ! iron ion transmembrane transporter activity +relationship: regulates GO:0005381 ! iron ion transmembrane transporter activity +created_by: kom +creation_date: 2015-05-20T14:05:00Z + +[Term] +id: GO:1904255 +name: negative regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "down regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of iron cation channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iron channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iron-specific channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of iron channel activity" EXACT [] +synonym: "negative regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity +relationship: negatively_regulates GO:0005381 ! iron ion transmembrane transporter activity +created_by: kom +creation_date: 2015-05-20T14:05:06Z + +[Term] +id: GO:1904256 +name: positive regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "activation of iron cation channel activity" NARROW [GOC:TermGenie] +synonym: "activation of iron channel activity" NARROW [GOC:TermGenie] +synonym: "activation of iron-specific channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of iron channel activity" EXACT [] +synonym: "positive regulation of iron transmembrane transporter activity" EXACT [] +synonym: "positive regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0005381 ! iron ion transmembrane transporter activity +relationship: positively_regulates GO:0005381 ! iron ion transmembrane transporter activity +created_by: kom +creation_date: 2015-05-20T14:05:12Z + [Term] id: GO:1904266 name: regulation of Schwann cell chemotaxis @@ -103229,6 +140602,52 @@ relationship: positively_regulates GO:0060083 ! smooth muscle contraction involv created_by: sl creation_date: 2015-06-10T18:46:23Z +[Term] +id: GO:1904341 +name: regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990765 ! colon smooth muscle contraction +relationship: regulates GO:1990765 ! colon smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:16:58Z + +[Term] +id: GO:1904342 +name: negative regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904341 ! regulation of colon smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990765 ! colon smooth muscle contraction +relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:17:05Z + +[Term] +id: GO:1904343 +name: positive regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904341 ! regulation of colon smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990765 ! colon smooth muscle contraction +relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:17:11Z + [Term] id: GO:1904344 name: regulation of gastric mucosal blood circulation @@ -103286,13 +140705,185 @@ relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulatio created_by: sl creation_date: 2015-06-11T21:20:50Z +[Term] +id: GO:1904347 +name: regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990770 ! small intestine smooth muscle contraction +relationship: regulates GO:1990770 ! small intestine smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:37:34Z + +[Term] +id: GO:1904348 +name: negative regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction +relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:37:40Z + +[Term] +id: GO:1904349 +name: positive regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990770 ! small intestine smooth muscle contraction +relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T21:37:46Z + +[Term] +id: GO:1904350 +name: regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:0042176 ! regulation of protein catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0007039 ! protein catabolic process in the vacuole +relationship: regulates GO:0007039 ! protein catabolic process in the vacuole +created_by: rl +creation_date: 2015-06-12T09:10:36Z + +[Term] +id: GO:1904351 +name: negative regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] +synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole +relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole +created_by: rl +creation_date: 2015-06-12T09:10:42Z + +[Term] +id: GO:1904352 +name: positive regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] +synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0007039 ! protein catabolic process in the vacuole +relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole +created_by: rl +creation_date: 2015-06-12T09:10:49Z + +[Term] +id: GO:1904362 +name: regulation of calcitonin secretion +def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [] +is_a: GO:0090276 ! regulation of peptide hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0036161 ! calcitonin secretion +relationship: regulates GO:0036161 ! calcitonin secretion + +[Term] +id: GO:1904363 +name: negative regulation of calcitonin secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [] +synonym: "down regulation of calcitonin secretion" EXACT [] +synonym: "down-regulation of calcitonin secretion" EXACT [] +synonym: "downregulation of calcitonin secretion" EXACT [] +synonym: "inhibition of calcitonin secretion" NARROW [] +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +is_a: GO:1904362 ! regulation of calcitonin secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0036161 ! calcitonin secretion +relationship: negatively_regulates GO:0036161 ! calcitonin secretion + +[Term] +id: GO:1904364 +name: positive regulation of calcitonin secretion +def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [] +synonym: "activation of calcitonin secretion" NARROW [] +synonym: "up regulation of calcitonin secretion" EXACT [] +synonym: "up-regulation of calcitonin secretion" EXACT [] +synonym: "upregulation of calcitonin secretion" EXACT [] +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +is_a: GO:1904362 ! regulation of calcitonin secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0036161 ! calcitonin secretion +relationship: positively_regulates GO:0036161 ! calcitonin secretion + [Term] id: GO:1904375 name: regulation of protein localization to cell periphery namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1990778 ! protein localization to cell periphery relationship: regulates GO:1990778 ! protein localization to cell periphery @@ -103308,7 +140899,6 @@ synonym: "down regulation of protein localization to cell periphery" EXACT [GOC: synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation @@ -103326,7 +140916,6 @@ synonym: "activation of protein localization to cell periphery" NARROW [GOC:Term synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1904375 ! regulation of protein localization to cell periphery intersection_of: GO:0065007 ! biological regulation @@ -103625,6 +141214,18 @@ relationship: positively_regulates GO:0050892 ! intestinal absorption created_by: rl creation_date: 2015-07-13T15:59:00Z +[Term] +id: GO:1904484 +name: cloacal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421] +is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0012478 ! cloacal gland +relationship: results_in_development_of UBERON:0012478 ! cloacal gland +created_by: mr +creation_date: 2015-07-15T22:14:39Z + [Term] id: GO:1904491 name: protein localization to ciliary transition zone @@ -103989,6 +141590,10 @@ alt_id: GO:0015758 def: "The process in which glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] synonym: "glucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:17234 ! glucose +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:17234 ! glucose created_by: vw creation_date: 2015-09-04T17:20:16Z @@ -104106,6 +141711,24 @@ relationship: positively_regulates GO:0048103 ! somatic stem cell division created_by: rph creation_date: 2015-09-14T08:47:34Z +[Term] +id: GO:1904680 +name: peptide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015197 +alt_id: GO:0015637 +def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] +synonym: "peptide transporter activity" RELATED [] +synonym: "peptide uptake permease activity" RELATED [] +xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" +is_a: GO:0042887 ! amide transmembrane transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: has_primary_input CHEBI:16670 ! peptide +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:16670 ! peptide +created_by: tb +creation_date: 2015-09-22T18:50:41Z + [Term] id: GO:1904691 name: negative regulation of type B pancreatic cell proliferation @@ -104176,6 +141799,74 @@ relationship: results_in_morphogenesis_of UBERON:0001891 ! midbrain created_by: bf creation_date: 2015-09-29T09:15:28Z +[Term] +id: GO:1904697 +name: regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990863 ! acinar cell proliferation +relationship: regulates GO:1990863 ! acinar cell proliferation +created_by: sl +creation_date: 2015-09-30T15:19:50Z + +[Term] +id: GO:1904698 +name: negative regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:1904697 ! regulation of acinar cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990863 ! acinar cell proliferation +relationship: negatively_regulates GO:1990863 ! acinar cell proliferation +created_by: sl +creation_date: 2015-09-30T15:19:57Z + +[Term] +id: GO:1904699 +name: positive regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:1904697 ! regulation of acinar cell proliferation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990863 ! acinar cell proliferation +relationship: positively_regulates GO:1990863 ! acinar cell proliferation +created_by: sl +creation_date: 2015-09-30T15:20:03Z + [Term] id: GO:1904705 name: regulation of vascular associated smooth muscle cell proliferation @@ -104298,22 +141989,6 @@ relationship: results_in_movement_of CL:0000359 ! vascular associated smooth mus created_by: rph creation_date: 2015-10-15T09:56:00Z -[Term] -id: GO:1904739 -name: regulation of synapse organization by posttranscriptional regulation of gene expression -namespace: biological_process -def: "A posttranscriptional regulation of gene expression that results in regulation of synapse organization." [GO_REF:0000063, GOC:rb, GOC:TermGenie, PMID:20729808] -synonym: "regulation of synapse development by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] -synonym: "regulation of synapse morphogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] -synonym: "regulation of synapse organisation by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] -synonym: "regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] -is_a: GO:0010608 ! posttranscriptional regulation of gene expression -is_a: GO:0050807 ! regulation of synapse organization -intersection_of: GO:0010608 ! posttranscriptional regulation of gene expression -intersection_of: regulates GO:0050808 ! synapse organization -created_by: tb -creation_date: 2015-10-15T21:25:46Z - [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development @@ -105485,6 +143160,19 @@ relationship: regulates GO:0006643 ! membrane lipid metabolic process created_by: tb creation_date: 2016-03-08T20:41:32Z +[Term] +id: GO:1905039 +name: carboxylic acid transmembrane transport +namespace: biological_process +def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] +is_a: GO:1903825 ! organic acid transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33575 ! carboxylic acid +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:33575 ! carboxylic acid +created_by: vw +creation_date: 2016-03-09T15:33:53Z + [Term] id: GO:1905044 name: regulation of Schwann cell proliferation involved in axon regeneration @@ -105599,6 +143287,19 @@ relationship: positively_regulates GO:0035886 ! vascular associated smooth muscl created_by: rph creation_date: 2016-03-21T11:15:13Z +[Term] +id: GO:1905069 +name: allantois development +namespace: biological_process +def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579] +synonym: "allantoic bud development" RELATED [GOC:TermGenie] +is_a: GO:1903867 ! extraembryonic membrane development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: results_in_development_of UBERON:0004340 ! allantois +relationship: results_in_development_of UBERON:0004340 ! allantois +created_by: cls +creation_date: 2016-03-21T15:18:21Z + [Term] id: GO:1905082 name: regulation of mitochondrial translational elongation @@ -105821,6 +143522,100 @@ relationship: positively_regulates GO:0051307 ! meiotic chromosome separation created_by: dph creation_date: 2016-04-12T17:46:45Z +[Term] +id: GO:1905139 +name: apical ectodermal ridge formation +namespace: biological_process +def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] +synonym: "AER formation" RELATED [GOC:TermGenie] +synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis +intersection_of: results_in_formation_of UBERON:0004356 ! apical ectodermal ridge +relationship: part_of GO:0035107 ! appendage morphogenesis +relationship: results_in_formation_of UBERON:0004356 ! apical ectodermal ridge +created_by: dph +creation_date: 2016-04-13T11:46:40Z + +[Term] +id: GO:1905140 +name: regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1905139 ! apical ectodermal ridge formation +relationship: regulates GO:1905139 ! apical ectodermal ridge formation +created_by: dph +creation_date: 2016-04-13T12:16:40Z + +[Term] +id: GO:1905141 +name: negative regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] +synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] +synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] +synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] +synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905140 ! regulation of apical ectodermal ridge formation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1905139 ! apical ectodermal ridge formation +relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation +created_by: dph +creation_date: 2016-04-13T12:16:48Z + +[Term] +id: GO:1905142 +name: positive regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "activation of AER formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] +synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905140 ! regulation of apical ectodermal ridge formation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1905139 ! apical ectodermal ridge formation +relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation +created_by: dph +creation_date: 2016-04-13T12:16:57Z + [Term] id: GO:1905144 name: response to acetylcholine @@ -105848,6 +143643,27 @@ intersection_of: has_input CHEBI:15355 ! acetylcholine created_by: dos creation_date: 2016-04-14T08:54:58Z +[Term] +id: GO:1905146 +name: lysosomal protein catabolic process +namespace: biological_process +def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] +comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. +synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "cellular protein catabolic process in lysosome" EXACT [] +synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "lysosomal protein catabolism" EXACT [GOC:bf] +synonym: "lysosomal protein degradation" EXACT [GOC:bf] +synonym: "lysosomal proteolysis" RELATED [PMID:24334770] +synonym: "proteolysis within lysosome" RELATED [GOC:bf] +is_a: GO:0007039 ! protein catabolic process in the vacuole +intersection_of: GO:0030163 ! protein catabolic process +intersection_of: occurs_in GO:0005764 ! lysosome +relationship: occurs_in GO:0005764 ! lysosome +created_by: bf +creation_date: 2016-04-14T12:50:34Z + [Term] id: GO:1905147 name: regulation of smooth muscle hypertrophy @@ -105897,6 +143713,140 @@ relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy created_by: bc creation_date: 2016-04-15T12:47:24Z +[Term] +id: GO:1905165 +name: regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937] +synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1905146 ! lysosomal protein catabolic process +relationship: regulates GO:1905146 ! lysosomal protein catabolic process +created_by: bf +creation_date: 2016-04-26T12:10:01Z + +[Term] +id: GO:1905166 +name: negative regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole +is_a: GO:1905165 ! regulation of lysosomal protein catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1905146 ! lysosomal protein catabolic process +relationship: negatively_regulates GO:1905146 ! lysosomal protein catabolic process +created_by: bf +creation_date: 2016-04-26T12:10:10Z + +[Term] +id: GO:1905167 +name: positive regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole +is_a: GO:1905165 ! regulation of lysosomal protein catabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1905146 ! lysosomal protein catabolic process +relationship: positively_regulates GO:1905146 ! lysosomal protein catabolic process +created_by: bf +creation_date: 2016-04-26T12:10:19Z + [Term] id: GO:1905178 name: regulation of cardiac muscle tissue regeneration @@ -106094,20 +144044,27 @@ creation_date: 2016-06-07T10:02:32Z id: GO:1905268 name: negative regulation of chromatin organization namespace: biological_process +alt_id: GO:0045798 alt_id: GO:1903309 def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] +synonym: "down regulation of chromatin assembly or disassembly" RELATED [] synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromatin assembly or disassembly" RELATED [] synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "downregulation of chromatin assembly or disassembly" RELATED [] synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "inhibition of chromatin assembly or disassembly" NARROW [] synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] +synonym: "negative regulation of chromatin assembly or disassembly" RELATED [] +synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] synonym: "negative regulation of chromatin modification" RELATED [] synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] @@ -106116,6 +144073,7 @@ is_a: GO:1902275 ! regulation of chromatin organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006325 ! chromatin organization relationship: negatively_regulates GO:0006325 ! chromatin organization +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22766 xsd:anyURI created_by: pr creation_date: 2016-06-15T20:14:47Z @@ -106123,20 +144081,28 @@ creation_date: 2016-06-15T20:14:47Z id: GO:1905269 name: positive regulation of chromatin organization namespace: biological_process +alt_id: GO:0045799 alt_id: GO:1903310 def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] +synonym: "activation of chromatin assembly or disassembly" NARROW [] synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] +synonym: "positive regulation of chromatin assembly or disassembly" RELATED [] +synonym: "positive regulation of chromatin assembly/disassembly" RELATED [] synonym: "positive regulation of chromatin modification" RELATED [] synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "stimulation of chromatin assembly or disassembly" NARROW [] +synonym: "up regulation of chromatin assembly or disassembly" RELATED [] synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromatin assembly or disassembly" RELATED [] synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "upregulation of chromatin assembly or disassembly" EXACT [] synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] @@ -106145,6 +144111,7 @@ is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006325 ! chromatin organization relationship: positively_regulates GO:0006325 ! chromatin organization +property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22766 xsd:anyURI created_by: pr creation_date: 2016-06-15T20:14:56Z @@ -106265,6 +144232,56 @@ relationship: positively_regulates GO:0014033 ! neural crest cell differentiatio created_by: rl creation_date: 2016-06-28T15:02:16Z +[Term] +id: GO:1905298 +name: regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0060284 ! regulation of cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0060576 ! intestinal epithelial cell development +relationship: regulates GO:0060576 ! intestinal epithelial cell development +created_by: rph +creation_date: 2016-06-30T11:40:47Z + +[Term] +id: GO:1905299 +name: negative regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905298 ! regulation of intestinal epithelial cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0060576 ! intestinal epithelial cell development +relationship: negatively_regulates GO:0060576 ! intestinal epithelial cell development +created_by: rph +creation_date: 2016-06-30T11:40:55Z + +[Term] +id: GO:1905300 +name: positive regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie] +synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905298 ! regulation of intestinal epithelial cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0060576 ! intestinal epithelial cell development +relationship: positively_regulates GO:0060576 ! intestinal epithelial cell development +created_by: rph +creation_date: 2016-06-30T11:41:02Z + [Term] id: GO:1905304 name: regulation of cardiac myofibril assembly @@ -106983,7 +145000,6 @@ def: "Any process that modulates the frequency, rate or extent of protein locali synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072657 ! protein localization to membrane relationship: regulates GO:0072657 ! protein localization to membrane @@ -107009,7 +145025,6 @@ synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation @@ -107037,7 +145052,6 @@ synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGeni synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905475 ! regulation of protein localization to membrane intersection_of: GO:0065007 ! biological regulation @@ -107689,7 +145703,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0071168 ! protein localization to chromatin relationship: regulates GO:0071168 ! protein localization to chromatin @@ -107846,6 +145859,25 @@ relationship: results_in_disassembly_of GO:0005634 ! nucleus created_by: pr creation_date: 2016-11-14T13:38:57Z +[Term] +id: GO:1905706 +name: regulation of mitochondrial ATP synthesis coupled proton transport +def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [] +is_a: GO:2001169 ! regulation of ATP biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis +relationship: regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis + +[Term] +id: GO:1905707 +name: negative regulation of mitochondrial ATP synthesis coupled proton transport +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [] +is_a: GO:1905706 ! regulation of mitochondrial ATP synthesis coupled proton transport +is_a: GO:2001170 ! negative regulation of ATP biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis +relationship: negatively_regulates GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis + [Term] id: GO:1905720 name: cytoplasmic microtubule bundle @@ -108343,7 +146375,6 @@ synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:Te synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] is_a: GO:0032880 ! regulation of protein localization -is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1902463 ! protein localization to cell leading edge relationship: regulates GO:1902463 ! protein localization to cell leading edge @@ -108374,7 +146405,6 @@ synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:T synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:1903828 ! negative regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation @@ -108407,7 +146437,6 @@ synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC: synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1903829 ! positive regulation of protein localization is_a: GO:1905871 ! regulation of protein localization to cell leading edge intersection_of: GO:0065007 ! biological regulation @@ -108936,19 +146965,6 @@ relationship: occurs_in CL:0009001 ! compound eye retinal cell created_by: pr creation_date: 2012-12-12T10:21:07Z -[Term] -id: GO:1990104 -name: DNA bending complex -namespace: cellular_component -def: "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674] -synonym: "histone-like DNA binding complex" NARROW [GOC:bhm] -is_a: GO:0032991 ! protein-containing complex -intersection_of: GO:0032991 ! protein-containing complex -intersection_of: capable_of GO:0008301 ! DNA binding, bending -relationship: capable_of GO:0008301 ! DNA binding, bending -created_by: bhm -creation_date: 2013-05-20T09:29:06Z - [Term] id: GO:1990138 name: neuron projection extension @@ -108977,9 +146993,9 @@ synonym: "secretion of exosome" EXACT [PMID:18617898] is_a: GO:0006887 ! exocytosis is_a: GO:0051650 ! establishment of vesicle localization intersection_of: GO:0006887 ! exocytosis -intersection_of: transports_or_maintains_localization_of GO:0070062 ! extracellular exosome +intersection_of: has_primary_input GO:0070062 ! extracellular exosome +relationship: has_primary_input GO:0070062 ! extracellular exosome relationship: part_of GO:0097734 ! extracellular exosome biogenesis -relationship: transports_or_maintains_localization_of GO:0070062 ! extracellular exosome property_value: RO:0002161 NCBITaxon:4890 created_by: hjd creation_date: 2013-09-04T21:08:14Z @@ -109002,7 +147018,7 @@ name: transferase complex namespace: cellular_component def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] is_a: GO:1902494 ! catalytic complex -intersection_of: GO:0032991 ! protein-containing complex +intersection_of: GO:1902494 ! catalytic complex intersection_of: capable_of GO:0016740 ! transferase activity relationship: capable_of GO:0016740 ! transferase activity created_by: bhm @@ -109046,6 +147062,19 @@ relationship: has_target_end_location GO:0000785 ! chromatin created_by: mah creation_date: 2014-01-30T15:55:34Z +[Term] +id: GO:1990351 +name: transporter complex +namespace: cellular_component +def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] +comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex +intersection_of: GO:0032991 ! protein-containing complex +intersection_of: capable_of GO:0005215 ! transporter activity +relationship: capable_of GO:0005215 ! transporter activity +created_by: bhm +creation_date: 2014-03-26T14:23:27Z + [Term] id: GO:1990413 name: eyespot apparatus @@ -109057,17 +147086,39 @@ is_a: GO:0043231 ! intracellular membrane-bounded organelle created_by: cjm creation_date: 2014-07-03T21:26:24Z +[Term] +id: GO:1990461 +name: detoxification of iron ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556] +is_a: GO:0061687 ! detoxification of inorganic compound +intersection_of: GO:0098754 ! detoxification +intersection_of: has_input CHEBI:24875 ! iron cation +relationship: has_input CHEBI:24875 ! iron cation +relationship: part_of GO:0010039 ! response to iron ion +created_by: sart +creation_date: 2014-08-19T10:12:46Z + [Term] id: GO:1990613 name: mitochondrial membrane fusion -namespace: biological_process -def: "The joining of two lipid bilayers that surround the mitochondria." [PMID:12052774] +def: "The joining of two lipid bilayers that surround the mitochondria." [] is_a: GO:0007006 ! mitochondrial membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion intersection_of: occurs_in GO:0005739 ! mitochondrion -created_by: vw -creation_date: 2015-01-21T06:58:18Z + +[Term] +id: GO:1990705 +name: cholangiocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010] +synonym: "hepatoblast proliferation" EXACT [] +is_a: GO:0050673 ! epithelial cell proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:1000488 ! cholangiocyte +relationship: acts_on_population_of CL:1000488 ! cholangiocyte +creation_date: 2015-03-16T23:23:50Z [Term] id: GO:1990716 @@ -109108,6 +147159,9 @@ namespace: biological_process def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] is_a: GO:0009987 ! cellular process is_a: GO:0098754 ! detoxification +intersection_of: GO:0098754 ! detoxification +intersection_of: occurs_in CL:0000000 ! cell +relationship: occurs_in CL:0000000 ! cell relationship: part_of GO:0097237 ! cellular response to toxic substance created_by: vw creation_date: 2015-05-18T16:17:46Z @@ -109124,6 +147178,21 @@ intersection_of: results_in_movement_of CL:0002573 ! Schwann cell created_by: sl creation_date: 2015-05-21T19:19:09Z +[Term] +id: GO:1990765 +name: colon smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253] +is_a: GO:0006939 ! smooth muscle contraction +intersection_of: GO:0006939 ! smooth muscle contraction +intersection_of: occurs_in UBERON:0001155 ! colon +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: occurs_in UBERON:0001155 ! colon +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: part_of GO:0014827 ! intestine smooth muscle contraction +created_by: sl +creation_date: 2015-06-10T18:29:21Z + [Term] id: GO:1990768 name: gastric mucosal blood circulation @@ -109137,12 +147206,27 @@ relationship: occurs_in UBERON:0004786 ! gastrointestinal system mucosa created_by: sl creation_date: 2015-06-10T20:11:09Z +[Term] +id: GO:1990770 +name: small intestine smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] +is_a: GO:0006939 ! smooth muscle contraction +intersection_of: GO:0006939 ! smooth muscle contraction +intersection_of: occurs_in UBERON:0002108 ! small intestine +relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: occurs_in UBERON:0002108 ! small intestine +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: part_of GO:0014827 ! intestine smooth muscle contraction +created_by: sl +creation_date: 2015-06-11T18:02:33Z + [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] -is_a: GO:0034613 ! cellular protein localization +is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: has_target_end_location GO:0071944 ! cell periphery relationship: has_target_end_location GO:0071944 ! cell periphery @@ -109159,12 +147243,26 @@ synonym: "maintenance of vacuole localization" EXACT [] synonym: "maintenance of vacuole location" EXACT [] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization -intersection_of: transports_or_maintains_localization_of GO:0005773 ! vacuole -relationship: transports_or_maintains_localization_of GO:0005773 ! vacuole +intersection_of: has_primary_input GO:0005773 ! vacuole +relationship: has_primary_input GO:0005773 ! vacuole property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/22182 xsd:anyURI created_by: mcc creation_date: 2015-09-10T08:16:02Z +[Term] +id: GO:1990863 +name: acinar cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] +synonym: "acinic cell proliferation" EXACT [] +synonym: "acinous cell proliferation" EXACT [] +is_a: GO:0050673 ! epithelial cell proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: acts_on_population_of CL:0000622 ! acinar cell +relationship: acts_on_population_of CL:0000622 ! acinar cell +created_by: sl +creation_date: 2015-09-25T14:26:09Z + [Term] id: GO:1990873 name: intrinsic component of plasma membrane of cell tip @@ -109210,6 +147308,20 @@ relationship: has_part CHEBI:33697 ! ribonucleic acid created_by: pr creation_date: 2015-11-19T12:26:37Z +[Term] +id: GO:1990917 +name: ooplasm +namespace: cellular_component +def: "The cytoplasm of an ovum." [PMID:19022436] +is_a: CARO:0000000 ! anatomical entity +is_a: GO:0099568 ! cytoplasmic region +intersection_of: GO:0005737 ! cytoplasm +intersection_of: part_of CL:0000025 ! egg cell +relationship: part_of CL:0000025 ! egg cell +property_value: RO:0002161 NCBITaxon:4751 +created_by: sl +creation_date: 2015-12-10T21:40:16Z + [Term] id: GO:2000018 name: regulation of male gonad development @@ -109293,6 +147405,66 @@ relationship: regulates GO:0017145 ! stem cell division created_by: tb creation_date: 2010-08-05T11:34:53Z +[Term] +id: GO:2000068 +name: regulation of defense response to insect +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] +synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] +is_a: GO:0031347 ! regulation of defense response +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002213 ! defense response to insect +relationship: regulates GO:0002213 ! defense response to insect +created_by: tb +creation_date: 2010-08-23T09:30:00Z + +[Term] +id: GO:2000074 +name: regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0060284 ! regulation of cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0003323 ! type B pancreatic cell development +relationship: regulates GO:0003323 ! type B pancreatic cell development +created_by: tb +creation_date: 2010-08-27T11:19:37Z + +[Term] +id: GO:2000077 +name: negative regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0003323 ! type B pancreatic cell development +relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development +created_by: tb +creation_date: 2010-08-27T11:21:17Z + +[Term] +id: GO:2000078 +name: positive regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0003323 ! type B pancreatic cell development +relationship: positively_regulates GO:0003323 ! type B pancreatic cell development +created_by: tb +creation_date: 2010-08-27T11:21:19Z + [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process @@ -109421,6 +147593,20 @@ relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthe created_by: tb creation_date: 2010-09-15T08:55:48Z +[Term] +id: GO:2000114 +name: regulation of establishment of cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] +synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] +synonym: "regulation of cell polarization" EXACT [GOC:obol] +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0030010 ! establishment of cell polarity +relationship: regulates GO:0030010 ! establishment of cell polarity +created_by: dph +creation_date: 2010-09-16T01:22:36Z + [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis @@ -109658,6 +147844,48 @@ relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis created_by: dph creation_date: 2010-10-13T12:46:31Z +[Term] +id: GO:2000185 +name: regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "regulation of phosphate membrane transport" EXACT [] +is_a: GO:0010966 ! regulation of phosphate transport +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035435 ! phosphate ion transmembrane transport +relationship: regulates GO:0035435 ! phosphate ion transmembrane transport +created_by: vw +creation_date: 2010-10-15T11:33:04Z + +[Term] +id: GO:2000186 +name: negative regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "negative regulation of phosphate membrane transport" EXACT [] +is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport +is_a: GO:2000185 ! regulation of phosphate transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport +relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport +created_by: vw +creation_date: 2010-10-15T11:33:08Z + +[Term] +id: GO:2000187 +name: positive regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "positive regulation of phosphate membrane transport" EXACT [] +is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport +is_a: GO:2000185 ! regulation of phosphate transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035435 ! phosphate ion transmembrane transport +relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport +created_by: vw +creation_date: 2010-10-15T11:33:10Z + [Term] id: GO:2000194 name: regulation of female gonad development @@ -109791,6 +148019,49 @@ relationship: positively_regulates GO:0006560 ! proline metabolic process created_by: mah creation_date: 2010-11-03T02:45:27Z +[Term] +id: GO:2000226 +name: regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0003310 ! pancreatic A cell differentiation +relationship: regulates GO:0003310 ! pancreatic A cell differentiation +created_by: mah +creation_date: 2010-11-09T03:43:37Z + +[Term] +id: GO:2000227 +name: negative regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0003310 ! pancreatic A cell differentiation +relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation +created_by: mah +creation_date: 2010-11-09T03:43:40Z + +[Term] +id: GO:2000228 +name: positive regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0003310 ! pancreatic A cell differentiation +relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation +created_by: mah +creation_date: 2010-11-09T03:43:42Z + [Term] id: GO:2000241 name: regulation of reproductive process @@ -109829,6 +148100,21 @@ relationship: positively_regulates GO:0022414 ! reproductive process created_by: mah creation_date: 2010-11-10T02:44:08Z +[Term] +id: GO:2000248 +name: negative regulation of establishment or maintenance of neuroblast polarity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] +synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +is_a: GO:0045769 ! negative regulation of asymmetric cell division +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity +relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity +created_by: vw +creation_date: 2010-11-11T11:40:34Z + [Term] id: GO:2000252 name: negative regulation of feeding behavior @@ -109872,8 +148158,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "regulation of protein activation pathway" EXACT [GOC:obol] synonym: "regulation of protein activitory cascade" EXACT [GOC:obol] -is_a: GO:0048583 ! regulation of response to stimulus -is_a: GO:0051246 ! regulation of protein metabolic process +is_a: GO:1903317 ! regulation of protein maturation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072376 ! protein activation cascade relationship: regulates GO:0072376 ! protein activation cascade @@ -109887,8 +148172,7 @@ namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol] synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol] -is_a: GO:0048585 ! negative regulation of response to stimulus -is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1903318 ! negative regulation of protein maturation is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072376 ! protein activation cascade @@ -109903,8 +148187,7 @@ namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah] synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol] synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol] -is_a: GO:0048584 ! positive regulation of response to stimulus -is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1903319 ! positive regulation of protein maturation is_a: GO:2000257 ! regulation of protein activation cascade intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072376 ! protein activation cascade @@ -110105,41 +148388,6 @@ relationship: positively_regulates GO:0038023 ! signaling receptor activity created_by: bf creation_date: 2010-12-02T09:28:50Z -[Term] -id: GO:2000278 -name: regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "regulation of DNA formation" EXACT [GOC:obol] -synonym: "regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0051052 ! regulation of DNA metabolic process -is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0071897 ! DNA biosynthetic process -relationship: regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2010-12-08T04:48:15Z - -[Term] -id: GO:2000279 -name: negative regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "negative regulation of DNA formation" EXACT [GOC:obol] -synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0051053 ! negative regulation of DNA metabolic process -is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process -is_a: GO:2000278 ! regulation of DNA biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0071897 ! DNA biosynthetic process -relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2010-12-08T04:48:20Z - [Term] id: GO:2000282 name: regulation of cellular amino acid biosynthetic process @@ -111175,25 +149423,6 @@ relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly created_by: ebc creation_date: 2011-04-03T07:22:06Z -[Term] -id: GO:2000573 -name: positive regulation of DNA biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] -synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] -synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] -synonym: "positive regulation of DNA formation" EXACT [GOC:obol] -synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] -is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process -is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051054 ! positive regulation of DNA metabolic process -is_a: GO:2000278 ! regulation of DNA biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process -relationship: positively_regulates GO:0071897 ! DNA biosynthetic process -created_by: yaf -creation_date: 2011-04-04T10:01:20Z - [Term] id: GO:2000606 name: regulation of cell proliferation involved in mesonephros development @@ -111232,6 +149461,41 @@ relationship: positively_regulates GO:0061209 ! cell proliferation involved in m created_by: yaf creation_date: 2011-04-18T08:42:25Z +[Term] +id: GO:2000609 +name: regulation of thyroid hormone generation +def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006590 ! thyroid hormone generation +relationship: regulates GO:0006590 ! thyroid hormone generation + +[Term] +id: GO:2000610 +name: negative regulation of thyroid hormone generation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:2000609 ! regulation of thyroid hormone generation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006590 ! thyroid hormone generation +relationship: negatively_regulates GO:0006590 ! thyroid hormone generation + +[Term] +id: GO:2000611 +name: positive regulation of thyroid hormone generation +def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:2000609 ! regulation of thyroid hormone generation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006590 ! thyroid hormone generation +relationship: positively_regulates GO:0006590 ! thyroid hormone generation + [Term] id: GO:2000647 name: negative regulation of stem cell proliferation @@ -111258,6 +149522,50 @@ relationship: positively_regulates GO:0072089 ! stem cell proliferation created_by: dph creation_date: 2011-04-27T01:04:25Z +[Term] +id: GO:2000649 +name: regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0015081 ! sodium ion transmembrane transporter activity +relationship: regulates GO:0015081 ! sodium ion transmembrane transporter activity +created_by: yaf +creation_date: 2011-04-28T08:42:53Z + +[Term] +id: GO:2000650 +name: negative regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity +relationship: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity +created_by: yaf +creation_date: 2011-04-28T08:42:57Z + +[Term] +id: GO:2000651 +name: positive regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity +relationship: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity +created_by: yaf +creation_date: 2011-04-28T08:43:00Z + [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process @@ -111343,6 +149651,53 @@ relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process created_by: pr creation_date: 2011-05-09T10:56:24Z +[Term] +id: GO:2000674 +name: regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0097050 ! type B pancreatic cell apoptotic process +relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process +created_by: pr +creation_date: 2011-05-09T11:51:09Z + +[Term] +id: GO:2000675 +name: negative regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process +relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process +created_by: pr +creation_date: 2011-05-09T11:51:12Z + +[Term] +id: GO:2000676 +name: positive regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process +relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process +created_by: pr +creation_date: 2011-05-09T11:51:15Z + [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation @@ -111529,6 +149884,44 @@ relationship: positively_regulates GO:0048863 ! stem cell differentiation created_by: yaf creation_date: 2011-06-14T02:05:23Z +[Term] +id: GO:2000772 +name: regulation of cellular senescence +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0031323 ! regulation of cellular metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0090398 ! cellular senescence +relationship: regulates GO:0090398 ! cellular senescence +created_by: bf +creation_date: 2011-06-22T01:57:04Z + +[Term] +id: GO:2000773 +name: negative regulation of cellular senescence +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:2000772 ! regulation of cellular senescence +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0090398 ! cellular senescence +relationship: negatively_regulates GO:0090398 ! cellular senescence +created_by: bf +creation_date: 2011-06-22T01:57:08Z + +[Term] +id: GO:2000774 +name: positive regulation of cellular senescence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:2000772 ! regulation of cellular senescence +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0090398 ! cellular senescence +relationship: positively_regulates GO:0090398 ! cellular senescence +created_by: bf +creation_date: 2011-06-22T01:57:12Z + [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development @@ -111653,6 +150046,47 @@ relationship: regulates GO:0003007 ! heart morphogenesis created_by: vk creation_date: 2011-07-19T10:08:58Z +[Term] +id: GO:2000828 +name: regulation of parathyroid hormone secretion +def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [] +synonym: "regulation of parathormone secretion" EXACT [] +synonym: "regulation of parathyrin secretion" EXACT [] +synonym: "regulation of PTH secretion" EXACT [] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035898 ! parathyroid hormone secretion +relationship: regulates GO:0035898 ! parathyroid hormone secretion + +[Term] +id: GO:2000829 +name: negative regulation of parathyroid hormone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [] +synonym: "negative regulation of parathormone secretion" EXACT [] +synonym: "negative regulation of parathyrin secretion" EXACT [] +synonym: "negative regulation of PTH secretion" EXACT [] +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000828 ! regulation of parathyroid hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035898 ! parathyroid hormone secretion +relationship: negatively_regulates GO:0035898 ! parathyroid hormone secretion + +[Term] +id: GO:2000830 +name: positive regulation of parathyroid hormone secretion +def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [] +synonym: "positive regulation of parathormone secretion" EXACT [] +synonym: "positive regulation of parathyrin secretion" EXACT [] +synonym: "positive regulation of PTH secretion" EXACT [] +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000828 ! regulation of parathyroid hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035898 ! parathyroid hormone secretion +relationship: positively_regulates GO:0035898 ! parathyroid hormone secretion + [Term] id: GO:2000831 name: regulation of steroid hormone secretion @@ -111735,6 +150169,38 @@ relationship: positively_regulates GO:0035935 ! androgen secretion created_by: bf creation_date: 2011-07-26T08:39:51Z +[Term] +id: GO:2000843 +name: regulation of testosterone secretion +def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035936 ! testosterone secretion +relationship: regulates GO:0035936 ! testosterone secretion + +[Term] +id: GO:2000844 +name: negative regulation of testosterone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000843 ! regulation of testosterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035936 ! testosterone secretion +relationship: negatively_regulates GO:0035936 ! testosterone secretion + +[Term] +id: GO:2000845 +name: positive regulation of testosterone secretion +def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000843 ! regulation of testosterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035936 ! testosterone secretion +relationship: positively_regulates GO:0035936 ! testosterone secretion + [Term] id: GO:2000846 name: regulation of corticosteroid hormone secretion @@ -111852,6 +150318,96 @@ relationship: positively_regulates GO:0035934 ! corticosterone secretion created_by: bf creation_date: 2011-07-26T08:45:45Z +[Term] +id: GO:2000855 +name: regulation of mineralocorticoid secretion +def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [] +is_a: GO:2000846 ! regulation of corticosteroid hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035931 ! mineralocorticoid secretion +relationship: regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000856 +name: negative regulation of mineralocorticoid secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [] +is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035931 ! mineralocorticoid secretion +relationship: negatively_regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000857 +name: positive regulation of mineralocorticoid secretion +def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [] +is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035931 ! mineralocorticoid secretion +relationship: positively_regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000858 +name: regulation of aldosterone secretion +def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [] +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0035932 ! aldosterone secretion +relationship: regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000859 +name: negative regulation of aldosterone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [] +is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion +is_a: GO:2000858 ! regulation of aldosterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0035932 ! aldosterone secretion +relationship: negatively_regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000860 +name: positive regulation of aldosterone secretion +def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [] +is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion +is_a: GO:2000858 ! regulation of aldosterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035932 ! aldosterone secretion +relationship: positively_regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000870 +name: regulation of progesterone secretion +def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [] +is_a: GO:2000194 ! regulation of female gonad development +is_a: GO:2000831 ! regulation of steroid hormone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0042701 ! progesterone secretion +relationship: regulates GO:0042701 ! progesterone secretion + +[Term] +id: GO:2000871 +name: negative regulation of progesterone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [] +is_a: GO:2000195 ! negative regulation of female gonad development +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +is_a: GO:2000870 ! regulation of progesterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0042701 ! progesterone secretion +relationship: negatively_regulates GO:0042701 ! progesterone secretion + +[Term] +id: GO:2000872 +name: positive regulation of progesterone secretion +def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [] +is_a: GO:2000196 ! positive regulation of female gonad development +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +is_a: GO:2000870 ! regulation of progesterone secretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0042701 ! progesterone secretion +relationship: positively_regulates GO:0042701 ! progesterone secretion + [Term] id: GO:2000977 name: regulation of forebrain neuron differentiation @@ -112255,6 +150811,20 @@ relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic proce created_by: yaf creation_date: 2011-09-08T02:50:09Z +[Term] +id: GO:2001069 +name: glycogen binding +namespace: molecular_function +def: "Binding to glycogen." [GOC:mengo_curators] +synonym: "animal starch binding" RELATED [GOC:obol] +synonym: "liver starch binding" RELATED [GOC:obol] +is_a: GO:0030247 ! polysaccharide binding +intersection_of: GO:0005488 ! binding +intersection_of: has_input CHEBI:28087 ! glycogen +relationship: has_input CHEBI:28087 ! glycogen +created_by: jl +creation_date: 2011-09-14T12:01:06Z + [Term] id: GO:2001141 name: regulation of RNA biosynthetic process @@ -112273,6 +150843,86 @@ relationship: regulates GO:0032774 ! RNA biosynthetic process created_by: dph creation_date: 2011-10-17T11:36:25Z +[Term] +id: GO:2001151 +name: regulation of renal water transport +def: "Any process that modulates the frequency, rate or extent of renal water transport." [] +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051049 ! regulation of transport +is_a: GO:0098801 ! regulation of renal system process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0003097 ! renal water transport +relationship: regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001152 +name: negative regulation of renal water transport +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2001151 ! regulation of renal water transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0003097 ! renal water transport +relationship: negatively_regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001153 +name: positive regulation of renal water transport +def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2001151 ! regulation of renal water transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0003097 ! renal water transport +relationship: positively_regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001169 +name: regulation of ATP biosynthetic process +def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [] +synonym: "regulation of ATP anabolism" EXACT [] +synonym: "regulation of ATP biosynthesis" EXACT [] +synonym: "regulation of ATP formation" EXACT [] +synonym: "regulation of ATP regeneration" RELATED [] +synonym: "regulation of ATP synthesis" EXACT [] +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1903578 ! regulation of ATP metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006754 ! ATP biosynthetic process +relationship: regulates GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:2001170 +name: negative regulation of ATP biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [] +synonym: "negative regulation of ATP anabolism" EXACT [] +synonym: "negative regulation of ATP biosynthesis" EXACT [] +synonym: "negative regulation of ATP formation" EXACT [] +synonym: "negative regulation of ATP regeneration" RELATED [] +synonym: "negative regulation of ATP synthesis" EXACT [] +is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process +is_a: GO:1903579 ! negative regulation of ATP metabolic process +is_a: GO:2001169 ! regulation of ATP biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006754 ! ATP biosynthetic process +relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:2001171 +name: positive regulation of ATP biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [] +synonym: "positive regulation of ATP anabolism" EXACT [] +synonym: "positive regulation of ATP biosynthesis" EXACT [] +synonym: "positive regulation of ATP formation" EXACT [] +synonym: "positive regulation of ATP regeneration" RELATED [] +synonym: "positive regulation of ATP synthesis" EXACT [] +is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process +is_a: GO:1903580 ! positive regulation of ATP metabolic process +is_a: GO:2001169 ! regulation of ATP biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006754 ! ATP biosynthetic process +relationship: positively_regulates GO:0006754 ! ATP biosynthetic process + [Term] id: GO:2001198 name: regulation of dendritic cell differentiation @@ -112522,6 +151172,60164 @@ relationship: positively_regulates GO:0051276 ! chromosome organization created_by: yaf creation_date: 2011-12-02T02:01:26Z +[Term] +id: HP:0000001 +name: All +namespace: human_phenotype +comment: Root of all terms in the Human Phenotype Ontology. +xref: UMLS:C0444868 + +[Term] +id: HP:0000005 +name: Mode of inheritance +namespace: human_phenotype +alt_id: HP:0001453 +alt_id: HP:0001461 +def: "The pattern in which a particular genetic trait or disorder is passed from one generation to the next." [HPO:probinson] +synonym: "Inheritance" EXACT [] +xref: UMLS:C1708511 +is_a: HP:0000001 ! All + +[Term] +id: HP:0000006 +name: Autosomal dominant inheritance +namespace: human_phenotype +alt_id: HP:0001415 +alt_id: HP:0001447 +alt_id: HP:0001448 +alt_id: HP:0001451 +alt_id: HP:0001455 +alt_id: HP:0001456 +alt_id: HP:0001463 +def: "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators] +synonym: "Autosomal dominant" EXACT [] +synonym: "Autosomal dominant form" RELATED [HPO:skoehler] +synonym: "Autosomal dominant type" RELATED [HPO:skoehler] +xref: SNOMEDCT_US:263681008 +xref: UMLS:C0443147 +is_a: HP:0000005 ! Mode of inheritance + +[Term] +id: HP:0000077 +name: Abnormality of the kidney +namespace: human_phenotype +def: "An abnormality of the kidney." [HPO:probinson] +comment: The kidney is a paired organ whose primary function is the production of urine. +synonym: "Abnormal kidney" EXACT layperson [] +synonym: "Abnormality of the kidney" EXACT layperson [] +synonym: "Renal anomalies" EXACT [] +synonym: "Renal anomaly" EXACT [] +xref: MSH:D007674 +xref: SNOMEDCT_US:44513007 +xref: SNOMEDCT_US:90708001 +xref: UMLS:C0022658 +xref: UMLS:C0266292 +is_a: HP:0010935 ! Abnormality of the upper urinary tract + +[Term] +id: HP:0000078 +name: Abnormality of the genital system +namespace: human_phenotype +def: "An abnormality of the genital system." [HPO:probinson] +synonym: "Abnormality of the reproductive system" RELATED layperson [] +synonym: "Genital abnormalities" EXACT layperson [] +synonym: "Genital abnormality" EXACT layperson [] +synonym: "Genital anomalies" EXACT layperson [] +synonym: "Genital defects" EXACT layperson [] +xref: UMLS:C0281966 +xref: UMLS:C0744356 +is_a: HP:0000119 ! Abnormality of the genitourinary system + +[Term] +id: HP:0000079 +name: Abnormality of the urinary system +namespace: human_phenotype +def: "An abnormality of the urinary system." [HPO:probinson] +synonym: "Urinary tract abnormalities" EXACT layperson [] +synonym: "Urinary tract abnormality" EXACT layperson [] +synonym: "Urinary tract anomalies" EXACT layperson [] +xref: UMLS:C4021821 +is_a: HP:0000119 ! Abnormality of the genitourinary system + +[Term] +id: HP:0000080 +name: Abnormality of reproductive system physiology +namespace: human_phenotype +def: "An abnormal functionality of the genital system." [HPO:probinson] +synonym: "Abnormality of genital physiology" BROAD layperson [] +synonym: "Abnormality of reproductive system physiology" EXACT layperson [] +synonym: "Genital functional abnormality" EXACT layperson [] +xref: UMLS:C4020896 +xref: UMLS:C4021820 +is_a: HP:0000078 ! Abnormality of the genital system + +[Term] +id: HP:0000095 +name: Abnormal renal glomerulus morphology +namespace: human_phenotype +def: "A structural anomaly of the glomerulus." [Eurenomics:ewuehl, PMID:18184729] +comment: Each human kidney contains approximately one million nephrons. The glomerulus is the most proximal component of the nephron. The glomerulus of the mammalian kidney is a highly developed vascular bed that acts as a filter, allowing a filtrate of small molecules, such as water, sugars, electrolytes and small proteins, to pass through a barrier that retains high molecular weight proteins and cells in the circulation. +synonym: "Abnormality of renal glomerulus morphology" EXACT [] +synonym: "Morphologic abnormality of the renal glomerulus" EXACT [] +xref: UMLS:C4025889 +is_a: HP:0031263 ! Abnormal renal corpuscle morphology + +[Term] +id: HP:0000099 +name: Glomerulonephritis +namespace: human_phenotype +def: "Inflammation of the renal glomeruli." [HPO:probinson] +synonym: "Glomerular nephritis" EXACT [] +xref: MSH:D005921 +xref: SNOMEDCT_US:36171008 +xref: UMLS:C0017658 +is_a: HP:0000095 ! Abnormal renal glomerulus morphology +is_a: HP:0000123 ! Nephritis + +[Term] +id: HP:0000118 +name: Phenotypic abnormality +namespace: human_phenotype +def: "A phenotypic abnormality." [HPO:probinson] +comment: This is the root of the phenotypic abnormality subontology of the HPO. +synonym: "Organ abnormality" EXACT [] +xref: UMLS:C4021819 +is_a: HP:0000001 ! All + +[Term] +id: HP:0000119 +name: Abnormality of the genitourinary system +namespace: human_phenotype +alt_id: HP:0008658 +alt_id: HP:0008688 +alt_id: HP:0008704 +alt_id: HP:0008713 +def: "The presence of any abnormality of the genitourinary system." [HPO:curators] +synonym: "Abnormality of the GU system" EXACT abbreviation [] +synonym: "Genitourinary abnormality" EXACT [] +synonym: "Genitourinary disease" RELATED [] +synonym: "Genitourinary dysplasia" RELATED [] +synonym: "Genitourinary tract anomalies" EXACT [] +synonym: "Genitourinary tract malformation" EXACT [] +synonym: "Urogenital abnormalities" EXACT [] +synonym: "Urogenital anomalies" EXACT [] +xref: MSH:D014564 +xref: SNOMEDCT_US:287085006 +xref: SNOMEDCT_US:42030000 +xref: UMLS:C0042063 +xref: UMLS:C0080276 +xref: UMLS:C4020895 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0000123 +name: Nephritis +namespace: human_phenotype +alt_id: HP:0008634 +def: "The presence of inflammation affecting the kidney." [HPO:probinson] +synonym: "Kidney inflammation" EXACT layperson [ORCID:0000-0001-6908-9849] +xref: MSH:D009393 +xref: SNOMEDCT_US:52845002 +xref: UMLS:C0027697 +is_a: HP:0012211 ! Abnormal renal physiology +is_a: HP:0012649 ! Increased inflammatory response + +[Term] +id: HP:0000144 +name: Decreased fertility +namespace: human_phenotype +synonym: "Abnormal fertility" EXACT layperson [HPO:skoehler] +synonym: "Decreased fertility" EXACT layperson [] +xref: SNOMEDCT_US:17276009 +xref: UMLS:C0520927 +is_a: HP:0000080 ! Abnormality of reproductive system physiology + +[Term] +id: HP:0000152 +name: Abnormality of head or neck +namespace: human_phenotype +def: "An abnormality of head and neck." [HPO:probinson] +synonym: "Abnormality of head or neck" EXACT layperson [] +synonym: "Head and neck abnormality" EXACT layperson [] +xref: UMLS:C4021817 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0000234 +name: Abnormality of the head +namespace: human_phenotype +def: "An abnormality of the head." [HPO:probinson] +synonym: "Abnormal head" EXACT layperson [HPO:skoehler] +synonym: "Abnormality of the head" EXACT layperson [] +synonym: "Head abnormality" EXACT layperson [] +xref: UMLS:C4021812 +is_a: HP:0000152 ! Abnormality of head or neck + +[Term] +id: HP:0000271 +name: Abnormality of the face +namespace: human_phenotype +def: "An abnormality of the face." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormal face" EXACT layperson [HPO:skoehler] +synonym: "Abnormality of the countenance" BROAD [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of the face" EXACT layperson [] +synonym: "Abnormality of the physiognomy" BROAD [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of the visage" BROAD [ORCID:0000-0001-5889-4463] +synonym: "Anomaly of face" RELATED [ORCID:0000-0001-5889-4463] +synonym: "Anomaly of the face" RELATED [ORCID:0000-0001-5889-4463] +synonym: "Disorder of face" BROAD layperson [ORCID:0000-0001-5889-4463] +synonym: "Disorder of the face" NARROW layperson [ORCID:0000-0001-5889-4463] +synonym: "Facial abnormality" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Facial anomaly" RELATED [ORCID:0000-0001-5889-4463] +xref: SNOMEDCT_US:118930001 +xref: SNOMEDCT_US:32003007 +xref: SNOMEDCT_US:398206004 +xref: SNOMEDCT_US:398302004 +xref: UMLS:C0266617 +xref: UMLS:C1290857 +xref: UMLS:C4025871 +is_a: HP:0000234 ! Abnormality of the head + +[Term] +id: HP:0000315 +name: Abnormality of the orbital region +namespace: human_phenotype +alt_id: HP:0000284 +synonym: "Abnormality of the eye region" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of the region around the eyes" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Anomaly of the orbital region of the face" NARROW [ORCID:0000-0001-5889-4463] +synonym: "Deformity of the orbital region of the face" NARROW [ORCID:0000-0001-5889-4463] +synonym: "Malformation of the orbital region of the face" NARROW [ORCID:0000-0001-5889-4463] +xref: UMLS:C4025863 +is_a: HP:0000271 ! Abnormality of the face + +[Term] +id: HP:0000366 +name: Abnormality of the nose +namespace: human_phenotype +def: "An abnormality of the nose." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormality of the nose" EXACT layperson [] +synonym: "Anomaly of the nose" EXACT [ORCID:0000-0001-5889-4463] +synonym: "Deformity of the nose" NARROW layperson [ORCID:0000-0001-5889-4463] +synonym: "Malformation of the nose" NARROW layperson [ORCID:0000-0001-5889-4463] +synonym: "Nasal abnormality" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Nasal anomaly" EXACT [ORCID:0000-0001-5889-4463] +synonym: "Nasal deformity" NARROW layperson [ORCID:0000-0001-5889-4463] +synonym: "Nasal malformation" NARROW layperson [ORCID:0000-0001-5889-4463] +xref: SNOMEDCT_US:128274005 +xref: SNOMEDCT_US:72089000 +xref: UMLS:C0240547 +xref: UMLS:C0265736 +xref: UMLS:C2235909 +is_a: HP:0000271 ! Abnormality of the face + +[Term] +id: HP:0000478 +name: Abnormality of the eye +namespace: human_phenotype +def: "Any abnormality of the eye, including location, spacing, and intraocular abnormalities." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormal eye" EXACT layperson [HPO:skoehler] +synonym: "Abnormality of the eye" EXACT layperson [] +synonym: "Eye disease" RELATED layperson [] +xref: MSH:D005124 +xref: MSH:D005128 +xref: SNOMEDCT_US:19416009 +xref: SNOMEDCT_US:371405004 +xref: SNOMEDCT_US:371409005 +xref: UMLS:C0015393 +xref: UMLS:C0015397 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0000492 +name: Abnormal eyelid morphology +namespace: human_phenotype +alt_id: HP:0000285 +def: "An abnormality of the eyelids." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormality of the eyelid" EXACT layperson [] +synonym: "Abnormality of the eyelids" EXACT layperson [] +xref: UMLS:C4021803 +is_a: HP:0030669 ! Abnormal ocular adnexa morphology + +[Term] +id: HP:0000496 +name: Abnormality of eye movement +namespace: human_phenotype +alt_id: HP:0006860 +def: "An abnormality in voluntary or involuntary eye movements or their control." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormal extraocular movement" EXACT [] +synonym: "Abnormal extraocular movements" EXACT [] +synonym: "Abnormal eye motility" EXACT [] +synonym: "Abnormal eye movement" EXACT layperson [] +synonym: "Abnormal eye movements" EXACT layperson [] +synonym: "Abnormal motility of the globe of the eye" EXACT [ORCID:0000-0001-5208-3432, ORCID:0000-0001-5889-4463] +synonym: "Abnormal movement of the globe of the eye" EXACT [ORCID:0000-0001-5208-3432, ORCID:0000-0001-5889-4463] +synonym: "Abnormal ocular movements" EXACT [] +synonym: "Abnormality of eye movement" EXACT layperson [] +synonym: "Eye movement abnormalities" EXACT layperson [] +synonym: "Eye movement issue" EXACT layperson [] +synonym: "Ocular movement abnormalities" EXACT [] +synonym: "Oculomotor abnormalities" EXACT [] +xref: SNOMEDCT_US:103252009 +xref: UMLS:C0497202 +is_a: HP:0012373 ! Abnormal eye physiology + +[Term] +id: HP:0000504 +name: Abnormality of vision +namespace: human_phenotype +def: "Abnormality of eyesight (visual perception)." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormality of sight" EXACT layperson [ORCID:0000-0001-5208-3432, ORCID:0000-0001-5889-4463] +synonym: "Abnormality of vision" EXACT layperson [] +synonym: "Vision issue" EXACT layperson [] +xref: UMLS:C4025846 +is_a: HP:0012373 ! Abnormal eye physiology + +[Term] +id: HP:0000505 +name: Visual impairment +namespace: human_phenotype +alt_id: HP:0000516 +alt_id: HP:0000566 +alt_id: HP:0007758 +alt_id: HP:0007860 +alt_id: HP:0007983 +def: "Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery." [DDD:gblack] +subset: hposlim_core +synonym: "Impaired vision" EXACT layperson [] +synonym: "Loss of eyesight" EXACT layperson [] +synonym: "Poor vision" EXACT layperson [] +synonym: "Visual impairment" EXACT layperson [] +xref: MSH:D014786 +xref: MSH:D015354 +xref: SNOMEDCT_US:246635007 +xref: SNOMEDCT_US:397540003 +xref: SNOMEDCT_US:7973008 +xref: UMLS:C0042798 +xref: UMLS:C3665347 +is_a: HP:0000504 ! Abnormality of vision + +[Term] +id: HP:0000520 +name: Proptosis +namespace: human_phenotype +alt_id: HP:0000536 +alt_id: HP:0000644 +alt_id: HP:0000645 +alt_id: HP:0007711 +alt_id: HP:0007870 +def: "An eye that is protruding anterior to the plane of the face to a greater extent than is typical." [HPO:sdoelken, PMID:19125427] +comment: Some sources define "exophthalmos" as a protrusion of the globe greater than 18 mm and "proptosis" as a protusion equal to or less than 18 mm. Others define "exophthalmos" as protusion secondary to endocrine dysfunction and "proptosis" as any non-endocrine-mediated protusion (Source: Wikipedia). This finding should be distinguished frm underdevelopment of the supraorbital ridge or maxilla/zygoma. In proptosis, the globe is anteriorly protuberant to the overall plane of the face. +subset: hposlim_core +synonym: "Anterior bulging of the globe" EXACT [] +synonym: "Anterior bulging of the globe of eye" EXACT [] +synonym: "Bulging eye" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Exophthalmos" EXACT [] +synonym: "Eyeballs bulging out" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Ocular proptosis" EXACT [] +synonym: "Prominent eyes" EXACT layperson [] +synonym: "Prominent globes" EXACT layperson [] +synonym: "Protruding eyes" EXACT layperson [] +synonym: "Protrusio bulbi" EXACT [] +xref: MSH:D005094 +xref: SNOMEDCT_US:18265008 +xref: UMLS:C0015300 +xref: UMLS:C1837760 +xref: UMLS:C1848490 +xref: UMLS:C1862425 +is_a: HP:0100886 ! Abnormality of globe location + +[Term] +id: HP:0000572 +name: Visual loss +namespace: human_phenotype +def: "Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that)." [HPO:sdoelken] +synonym: "Loss of vision" EXACT layperson [] +synonym: "Vision loss" EXACT layperson [HPO:skoehler] +synonym: "Visual loss" EXACT layperson [] +xref: SNOMEDCT_US:7973008 +xref: UMLS:C3665386 +is_a: HP:0000505 ! Visual impairment + +[Term] +id: HP:0000657 +name: Oculomotor apraxia +namespace: human_phenotype +alt_id: HP:0000628 +alt_id: HP:0007764 +def: "Ocular motor apraxia is a deficiency in voluntary, horizontal, lateral, fast eye movements (saccades) with retention of slow pursuit movements. The inability to follow objects visually is often compensated by head movements. There may be decreased smooth pursuit, and cancellation of the vestibulo-ocular reflex." [HPO:probinson, PMID:20615230] +comment: Oculomotor apraxia leads defective or absent horizontal voluntary eye movements with head thrusting to look at objects to the side as well as jerky, abnormal eye movements. +subset: hposlim_core +synonym: "Defective or absent horizontal voluntary eye movements" RELATED [] +synonym: "Ocular motor apraxia" EXACT [] +xref: MSH:C537423 +xref: SNOMEDCT_US:193662007 +xref: UMLS:C3489733 +xref: UMLS:C4020886 +is_a: HP:0000496 ! Abnormality of eye movement +is_a: HP:0002186 ! Apraxia + +[Term] +id: HP:0000707 +name: Abnormality of the nervous system +namespace: human_phenotype +alt_id: HP:0001333 +alt_id: HP:0006987 +def: "An abnormality of the nervous system." [HPO:probinson] +comment: The nervous system comprises the neuraxis (brain, spinal cord, and ventricles), the autonomic nervous system, the enteric nervous system, and the peripheral nervous system. +synonym: "Abnormality of the nervous system" EXACT layperson [] +synonym: "Brain and/or spinal cord issue" BROAD layperson [] +synonym: "Neurologic abnormalities" EXACT layperson [] +synonym: "Neurological abnormality" EXACT layperson [] +xref: MSH:D009421 +xref: SNOMEDCT_US:88425004 +xref: UMLS:C0497552 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0000726 +name: Dementia +namespace: human_phenotype +alt_id: HP:0002274 +alt_id: HP:0007122 +alt_id: HP:0007150 +alt_id: HP:0007283 +def: "A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior." [HPO:probinson] +synonym: "Dementia" EXACT layperson [] +synonym: "Dementia, progressive" EXACT layperson [] +synonym: "Progressive dementia" EXACT layperson [] +xref: MSH:D003704 +xref: SNOMEDCT_US:52448006 +xref: UMLS:C0497327 +is_a: HP:0001268 ! Mental deterioration + +[Term] +id: HP:0000789 +name: Infertility +namespace: human_phenotype +synonym: "Infertility" EXACT layperson [] +xref: MSH:D007246 +xref: SNOMEDCT_US:15296000 +xref: SNOMEDCT_US:8619003 +xref: UMLS:C0021359 +is_a: HP:0000144 ! Decreased fertility + +[Term] +id: HP:0000818 +name: Abnormality of the endocrine system +namespace: human_phenotype +def: "An abnormality of the endocrine system." [HPO:probinson] +comment: The endocrine system is composed of glands that secrete hormones directly into the bloodstream and includes the following glands: thyroid, parathyroids, adrenals, pancreas, gonads (testicles and ovaries), and pituitary. Many other organs, such as the kidney, liver, and heart, have secondary endocrine functions. +synonym: "Endocrine system disease" RELATED [] +xref: MSH:D004700 +xref: SNOMEDCT_US:362969004 +xref: UMLS:C0014130 +xref: UMLS:C4025823 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0000822 +name: Hypertension +namespace: human_phenotype +alt_id: HP:0004949 +alt_id: HP:0005126 +def: "The presence of chronic increased pressure in the systemic arterial system." [HPO:probinson] +comment: Hypertension is sustained elevation of resting systolic BP (140 mm Hg or higher), diastolic BP (90 mm Hg or higher), or both. +synonym: "Arterial hypertension" EXACT [] +synonym: "High blood pressure" RELATED layperson [ORCID:0000-0001-5208-3432] +synonym: "Systemic hypertension" EXACT [] +xref: MSH:D006973 +xref: SNOMEDCT_US:24184005 +xref: SNOMEDCT_US:38341003 +xref: UMLS:C0020538 +xref: UMLS:C0497247 +is_a: HP:0032263 ! Increased blood pressure + +[Term] +id: HP:0000830 +name: Anterior hypopituitarism +namespace: human_phenotype +def: "A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone." [HPO:probinson] +xref: UMLS:C4025821 +is_a: HP:0040075 ! Hypopituitarism + +[Term] +id: HP:0000855 +name: Insulin resistance +namespace: human_phenotype +def: "Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels." [HPO:probinson] +synonym: "Body fails to respond to insulin" EXACT layperson [https://orcid.org/0000-0002-6548-5200] +xref: MSH:D007333 +xref: SNOMEDCT_US:48606007 +xref: UMLS:C0021655 +is_a: HP:0011014 ! Abnormal glucose homeostasis + +[Term] +id: HP:0000864 +name: Abnormality of the hypothalamus-pituitary axis +namespace: human_phenotype +alt_id: HP:0000838 +alt_id: HP:0000844 +def: "Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit." [DDD:spark] +xref: UMLS:C4025819 +is_a: HP:0000818 ! Abnormality of the endocrine system + +[Term] +id: HP:0000924 +name: Abnormality of the skeletal system +namespace: human_phenotype +def: "An abnormality of the skeletal system." [HPO:probinson] +synonym: "Abnormality of the skeletal system" EXACT layperson [] +synonym: "Skeletal abnormalities" EXACT layperson [] +synonym: "Skeletal anomalies" EXACT layperson [] +xref: UMLS:C4021790 +is_a: HP:0033127 ! Abnormality of the musculoskeletal system + +[Term] +id: HP:0000951 +name: Abnormality of the skin +namespace: human_phenotype +alt_id: HP:0001478 +alt_id: HP:0001479 +alt_id: HP:0005591 +alt_id: HP:0006736 +alt_id: HP:0007415 +alt_id: HP:0007580 +def: "An abnormality of the skin." [HPO:probinson] +subset: hposlim_core +synonym: "Abnormality of the skin" EXACT layperson [] +synonym: "dermatopathy" EXACT [HPO:skoehler] +synonym: "dermopathy" EXACT [HPO:skoehler] +synonym: "Skin abnormality" RELATED [] +xref: MSH:D012868 +xref: MSH:D012871 +xref: SNOMEDCT_US:199879009 +xref: SNOMEDCT_US:95320005 +xref: UMLS:C0037268 +xref: UMLS:C0037274 +is_a: HP:0001574 ! Abnormality of the integument + +[Term] +id: HP:0000964 +name: Eczema +namespace: human_phenotype +alt_id: HP:0001481 +def: "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." [HPO:probinson] +comment: Eczema has several forms including atopic dermatitis, contact dermatitis, dyshidrotic eczema, nummular eczema, seborrheic dermatitis, and stasis dermatitis. +synonym: "Eczema" EXACT layperson [] +xref: MSH:D004485 +xref: SNOMEDCT_US:281104002 +xref: SNOMEDCT_US:43116000 +xref: UMLS:C0013595 +is_a: HP:0011123 ! Inflammatory abnormality of the skin + +[Term] +id: HP:0001250 +name: Seizure +namespace: human_phenotype +alt_id: HP:0001275 +alt_id: HP:0001303 +alt_id: HP:0002125 +alt_id: HP:0002182 +alt_id: HP:0002279 +alt_id: HP:0002306 +alt_id: HP:0002348 +alt_id: HP:0002391 +alt_id: HP:0002417 +alt_id: HP:0002430 +alt_id: HP:0002431 +alt_id: HP:0002432 +alt_id: HP:0002434 +alt_id: HP:0002437 +alt_id: HP:0002466 +alt_id: HP:0002479 +alt_id: HP:0002794 +alt_id: HP:0006997 +alt_id: HP:0010520 +def: "A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain." [HPO:probinson, PMID:15816939] +comment: A type of electrographic seizure has been proposed in neonates which does not have a clinical correlate, it is electrographic only. The term epilepsy is not used to describe recurrent febrile seizures. Epilepsy presumably reflects an abnormally reduced seizure threshold. +synonym: "Epilepsy" RELATED layperson [] +synonym: "Epileptic seizure" EXACT [] +synonym: "Seizures" EXACT plural_form [] +xref: MSH:D004827 +xref: MSH:D012640 +xref: SNOMEDCT_US:128613002 +xref: SNOMEDCT_US:246545002 +xref: SNOMEDCT_US:313307000 +xref: SNOMEDCT_US:84757009 +xref: SNOMEDCT_US:91175000 +xref: UMLS:C0014544 +xref: UMLS:C0036572 +is_a: HP:0012638 ! Abnormal nervous system physiology + +[Term] +id: HP:0001251 +name: Ataxia +namespace: human_phenotype +alt_id: HP:0001253 +alt_id: HP:0002513 +alt_id: HP:0007050 +alt_id: HP:0007157 +def: "Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly)." [HPO:probinson] +comment: Ataxia can be differentiated into dyssynergy, asynergy, dysmetria (hypometria, hypermetria), dysdiadochokinesis, gait ataxia, truncal ataxia, limb ataxia, and dysarthria). Note: This term does not include sensory ataxia. +synonym: "Cerebellar ataxia" EXACT [] +xref: MSH:D002524 +xref: SNOMEDCT_US:85102008 +xref: UMLS:C0007758 +is_a: HP:0011443 ! Abnormality of coordination + +[Term] +id: HP:0001268 +name: Mental deterioration +namespace: human_phenotype +alt_id: HP:0002303 +alt_id: HP:0006822 +alt_id: HP:0007155 +alt_id: HP:0007253 +alt_id: HP:0007264 +alt_id: HP:0007298 +def: "Loss of previously present mental abilities, generally in adults." [HPO:probinson] +synonym: "Cognitive decline" EXACT layperson [] +synonym: "Cognitive decline, progressive" EXACT layperson [] +synonym: "Intellectual deterioration" EXACT layperson [] +synonym: "Mental deterioration" EXACT layperson [] +synonym: "Progressive cognitive decline" EXACT layperson [] +xref: MSH:D060825 +xref: UMLS:C0234985 +is_a: HP:0100543 ! Cognitive impairment + +[Term] +id: HP:0001287 +name: Meningitis +namespace: human_phenotype +def: "Inflammation of the meninges." [HPO:probinson] +xref: MSH:D008581 +xref: SNOMEDCT_US:7180009 +xref: UMLS:C0025289 +is_a: HP:0011450 ! Unusual CNS infection + +[Term] +id: HP:0001297 +name: Stroke +namespace: human_phenotype +alt_id: HP:0002452 +def: "Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain." [HPO:probinson] +synonym: "Cerebral vascular events" EXACT [] +synonym: "Cerebrovascular accident" EXACT [] +synonym: "Cerebrovascular accidents" RELATED [HPO:skoehler] +synonym: "Stroke" EXACT layperson [] +xref: MSH:D020521 +xref: SNOMEDCT_US:230690007 +xref: UMLS:C0038454 +is_a: HP:0100659 ! Abnormal cerebral vascular morphology + +[Term] +id: HP:0001367 +name: Abnormal joint morphology +namespace: human_phenotype +def: "An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join." [HPO:probinson] +synonym: "Abnormal shape of joints" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of the joints" EXACT layperson [] +synonym: "Anomaly of the joints" EXACT layperson [] +synonym: "Joint disease" RELATED layperson [] +xref: MSH:D007592 +xref: SNOMEDCT_US:399269003 +xref: UMLS:C0022408 +xref: UMLS:C0240083 +is_a: HP:0011842 ! Abnormality of skeletal morphology + +[Term] +id: HP:0001369 +name: Arthritis +namespace: human_phenotype +def: "Inflammation of a joint." [HPO:probinson] +synonym: "Arthritis" EXACT layperson [] +synonym: "Joint inflammation" EXACT layperson [ORCID:0000-0002-6548-5200] +xref: MSH:D001168 +xref: SNOMEDCT_US:3723001 +xref: UMLS:C0003864 +is_a: HP:0001367 ! Abnormal joint morphology + +[Term] +id: HP:0001370 +name: Rheumatoid arthritis +namespace: human_phenotype +def: "Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures." [HPO:probinson] +synonym: "RA" EXACT abbreviation [] +synonym: "Rheumatoid arthritis" EXACT layperson [] +xref: MSH:D001172 +xref: SNOMEDCT_US:69896004 +xref: UMLS:C0003873 +is_a: HP:0001369 ! Arthritis + +[Term] +id: HP:0001507 +name: Growth abnormality +namespace: human_phenotype +alt_id: HP:0008904 +synonym: "Abnormal growth" EXACT layperson [] +synonym: "Growth abnormality" EXACT layperson [] +synonym: "Growth issue" EXACT layperson [] +xref: UMLS:C0262361 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0001574 +name: Abnormality of the integument +namespace: human_phenotype +def: "An abnormality of the integument, which consists of the skin and the superficial fascia." [HPO:probinson] +comment: Abnormality of skin, hair, or nails. +xref: UMLS:C4025761 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0001608 +name: Abnormality of the voice +namespace: human_phenotype +comment: This term describes any abnormality of the voice, i.e., of the sounds produced by humans by the passage of air through the larynx and over the vocal cords, and then modified by the resonance organs, the nasopharynx, and the mouth. +synonym: "Abnormality of the voice" EXACT layperson [] +synonym: "Voice abnormality" EXACT layperson [] +xref: UMLS:C4021776 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0001609 +name: Hoarse voice +namespace: human_phenotype +alt_id: HP:0001613 +alt_id: HP:0001619 +def: "Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky." [HPO:probinson] +synonym: "Hoarse voice" EXACT layperson [] +synonym: "Hoarseness" EXACT layperson [] +synonym: "Husky voice" EXACT layperson [] +xref: MSH:D006685 +xref: SNOMEDCT_US:50219008 +xref: UMLS:C0019825 +xref: UMLS:C1854348 +is_a: HP:0001608 ! Abnormality of the voice + +[Term] +id: HP:0001626 +name: Abnormality of the cardiovascular system +namespace: human_phenotype +def: "Any abnormality of the cardiovascular system." [HPO:probinson] +comment: The cardiovascular system consists of the heart, vasculature, and the lymphatic system. +synonym: "Abnormality of the cardiovascular system" EXACT layperson [] +synonym: "Cardiovascular abnormality" EXACT layperson [] +synonym: "Cardiovascular disease" RELATED layperson [] +xref: MSH:D002318 +xref: MSH:D018376 +xref: SNOMEDCT_US:49601007 +xref: UMLS:C0007222 +xref: UMLS:C0243050 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0001686 +name: Loss of voice +namespace: human_phenotype +synonym: "Aphonia" EXACT [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0001-5889-4463] +xref: MSH:D001044 +xref: SNOMEDCT_US:441913003 +xref: SNOMEDCT_US:44564008 +xref: UMLS:C0003564 +is_a: HP:0001608 ! Abnormality of the voice + +[Term] +id: HP:0001732 +name: Abnormality of the pancreas +namespace: human_phenotype +def: "An abnormality of the pancreas." [HPO:probinson] +synonym: "Abnormality of the pancreas" EXACT layperson [] +synonym: "Pancreatic disease" RELATED layperson [] +xref: MSH:D010182 +xref: SNOMEDCT_US:3855007 +xref: UMLS:C0030286 +xref: UMLS:C4025751 +is_a: HP:0002012 ! Abnormality of the abdominal organs + +[Term] +id: HP:0001733 +name: Pancreatitis +namespace: human_phenotype +def: "The presence of inflammation in the pancreas." [HPO:probinson] +synonym: "Pancreatic inflammation" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: MSH:D010195 +xref: SNOMEDCT_US:75694006 +xref: UMLS:C0030305 +is_a: HP:0012091 ! Abnormality of pancreas physiology +is_a: HP:0012649 ! Increased inflammatory response + +[Term] +id: HP:0001735 +name: Acute pancreatitis +namespace: human_phenotype +alt_id: HP:0004512 +def: "A acute form of pancreatitis." [HPO:probinson] +synonym: "Acute pancreatic inflammation" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Pancreatitis, acute" EXACT [] +xref: SNOMEDCT_US:197456007 +xref: UMLS:C0001339 +is_a: HP:0001733 ! Pancreatitis + +[Term] +id: HP:0001824 +name: Weight loss +namespace: human_phenotype +def: "Reduction of total body weight." [HPO:probinson] +synonym: "Loss of weight" EXACT [] +xref: MSH:D015431 +xref: SNOMEDCT_US:161832001 +xref: SNOMEDCT_US:262285001 +xref: SNOMEDCT_US:89362005 +xref: UMLS:C1262477 +is_a: HP:0004325 ! Decreased body weight + +[Term] +id: HP:0001939 +name: Abnormality of metabolism/homeostasis +namespace: human_phenotype +alt_id: HP:0002146 +alt_id: HP:0004355 +alt_id: HP:0004367 +synonym: "Laboratory abnormality" EXACT layperson [] +synonym: "Metabolism abnormality" EXACT layperson [] +xref: UMLS:C4021768 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0001944 +name: Dehydration +namespace: human_phenotype +synonym: "Dehydration" EXACT layperson [] +synonym: "Exsiccosis" EXACT [] +xref: MSH:D003681 +xref: SNOMEDCT_US:34095006 +xref: UMLS:C0011175 +is_a: HP:0011032 ! Abnormality of fluid regulation + +[Term] +id: HP:0002011 +name: Morphological central nervous system abnormality +namespace: human_phenotype +alt_id: HP:0002405 +alt_id: HP:0002413 +alt_id: HP:0002481 +alt_id: HP:0007319 +def: "A structural abnormality of the central nervous system." [HPO:probinson] +synonym: "Abnormality of the central nervous system" EXACT [] +synonym: "Central nervous system disease" RELATED [] +synonym: "Morphological abnormality of the central nervous system" EXACT [] +synonym: "Morphological abnormality of the CNS" EXACT abbreviation [] +xref: MSH:D002493 +xref: SNOMEDCT_US:23853001 +xref: UMLS:C0007682 +xref: UMLS:C4021765 +is_a: HP:0012639 ! Abnormal nervous system morphology + +[Term] +id: HP:0002012 +name: Abnormality of the abdominal organs +namespace: human_phenotype +def: "An abnormality of the viscera of the abdomen." [HPO:probinson] +comment: The abdominal organs comprise the stomach, small and large intestines, liver, pancreas, bile tract, and spleen. +synonym: "Abnormality of the abdominal organs" EXACT layperson [] +synonym: "Gastrointestinal tract defects" EXACT [] +xref: UMLS:C4021764 +is_a: HP:0025031 ! Abnormality of the digestive system + +[Term] +id: HP:0002013 +name: Vomiting +namespace: human_phenotype +def: "Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions." [HPO:probinson] +subset: hposlim_core +synonym: "Emesis" EXACT [] +synonym: "Throwing up" EXACT layperson [] +synonym: "Vomiting" EXACT layperson [] +xref: MEDDRA:10047700 "Vomiting" +xref: MSH:D014839 +xref: SNOMEDCT_US:249497008 +xref: SNOMEDCT_US:300359004 +xref: SNOMEDCT_US:422400008 +xref: UMLS:C0042963 +is_a: HP:0002017 ! Nausea and vomiting + +[Term] +id: HP:0002014 +name: Diarrhea +namespace: human_phenotype +def: "Abnormally increased frequency of loose or watery bowel movements." [HPO:probinson] +synonym: "Diarrhea" EXACT layperson [] +synonym: "Diarrhoea" EXACT uk_spelling [] +synonym: "Watery stool" EXACT layperson [] +xref: MSH:D003967 +xref: SNOMEDCT_US:267060006 +xref: SNOMEDCT_US:62315008 +xref: UMLS:C0011991 +is_a: HP:0011458 ! Abdominal symptom + +[Term] +id: HP:0002017 +name: Nausea and vomiting +namespace: human_phenotype +def: "Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea." [PMID:26770271] +synonym: "Nausea and vomiting" EXACT layperson [] +xref: SNOMEDCT_US:16932000 +xref: UMLS:C0027498 +is_a: HP:0011458 ! Abdominal symptom + +[Term] +id: HP:0002019 +name: Constipation +namespace: human_phenotype +alt_id: HP:0002241 +alt_id: HP:0003786 +def: "Infrequent or difficult evacuation of feces." [HPO:probinson] +synonym: "Constipation" EXACT layperson [] +synonym: "Costiveness" EXACT [] +synonym: "Dyschezia" EXACT [] +xref: MSH:D003248 +xref: SNOMEDCT_US:14760008 +xref: SNOMEDCT_US:225595004 +xref: UMLS:C0009806 +xref: UMLS:C0237326 +is_a: HP:0011458 ! Abdominal symptom + +[Term] +id: HP:0002027 +name: Abdominal pain +namespace: human_phenotype +def: "An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen." [HPO:probinson] +comment: Abdominal pain can be crampy, achy, dull, intermittent or sharp. The terms stomach ache and stomach cramps are nonmedical terms often used to describe pain in the mid- or upper abdominal area, even though it is not the case that the (smooth) muscles of the stomach or the abdomen have cramps. Stomach pain is another layperson term commonly used to refer to abdominal pain. +subset: hposlim_core +synonym: "Abdominal discomfort" RELATED layperson [] +synonym: "Abdominal pain" EXACT layperson [] +synonym: "Gastro pain" BROAD layperson [] +synonym: "Gastrointestinal pain" BROAD layperson [] +synonym: "Pain in stomach" EXACT layperson [] +synonym: "Stomach pain" EXACT layperson [ORCID:0000-0002-0736-9199] +synonym: "Upset stomach" RELATED layperson [ORCID:0000-0001-6439-2224] +xref: MEDDRA:10000081 "Abdominal pain" +xref: MSH:D015746 +xref: SNOMEDCT_US:21522001 +xref: UMLS:C0000737 +is_a: HP:0011458 ! Abdominal symptom +is_a: HP:0012531 ! Pain + +[Term] +id: HP:0002060 +name: Abnormal cerebral morphology +namespace: human_phenotype +def: "Any structural abnormality of the telencephalon, which is also known as the cerebrum." [HPO:probinson] +synonym: "Abnormality of the cerebrum" EXACT [] +synonym: "Abnormality of the telencephalon" EXACT [] +synonym: "Cerebral lesion" EXACT [] +xref: UMLS:C4021762 +is_a: HP:0100547 ! Abnormality of forebrain morphology + +[Term] +id: HP:0002086 +name: Abnormality of the respiratory system +namespace: human_phenotype +def: "An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles." [HPO:probinson] +synonym: "Respiratory abnormality" EXACT [] +xref: UMLS:C4018871 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0002088 +name: Abnormal lung morphology +namespace: human_phenotype +def: "Any structural anomaly of the lung." [HPO:probinson] +synonym: "Abnormality of lung structure" EXACT layperson [] +synonym: "Abnormality of the lungs" EXACT layperson [] +synonym: "Abnormally shaped lung" EXACT layperson [] +synonym: "Lung disease" RELATED layperson [] +synonym: "Unusal lung shape" EXACT layperson [] +xref: MSH:D008171 +xref: SNOMEDCT_US:19829001 +xref: UMLS:C0024115 +xref: UMLS:C4021760 +is_a: HP:0012252 ! Abnormal respiratory system morphology + +[Term] +id: HP:0002090 +name: Pneumonia +namespace: human_phenotype +def: "Inflammation of any part of the lung parenchyma." [HPO:probinson] +synonym: "Pneumonia" EXACT layperson [] +xref: MSH:D011014 +xref: SNOMEDCT_US:233604007 +xref: UMLS:C0032285 +is_a: HP:0011947 ! Respiratory tract infection +is_a: HP:0012649 ! Increased inflammatory response + +[Term] +id: HP:0002102 +name: Pleuritis +namespace: human_phenotype +def: "Inflammation of the pleura." [HPO:sdoelken] +synonym: "Inflammation of tissues lining lungs and chest" EXACT layperson [ORCID:0000-0002-6548-5200] +synonym: "Pleurisy" EXACT [HPO:sdoelken] +xref: MSH:D010998 +xref: SNOMEDCT_US:196075003 +xref: UMLS:C0032231 +is_a: HP:0002103 ! Abnormal pleura morphology + +[Term] +id: HP:0002103 +name: Abnormal pleura morphology +namespace: human_phenotype +def: "An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls." [HPO:probinson] +synonym: "Abnormality of the pleura" EXACT [] +xref: UMLS:C4025726 +is_a: HP:0002088 ! Abnormal lung morphology + +[Term] +id: HP:0002105 +name: Hemoptysis +namespace: human_phenotype +def: "Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs." [HPO:probinson] +synonym: "Coughing up blood" EXACT layperson [ORCID:0000-0002-6548-5200] +synonym: "Coughing up blood or blood-stained mucus" RELATED layperson [] +synonym: "Haemoptysis" EXACT uk_spelling [] +xref: MSH:D006469 +xref: SNOMEDCT_US:66857006 +xref: SNOMEDCT_US:6686005 +xref: UMLS:C0019079 +is_a: HP:0032016 ! Abnormal sputum + +[Term] +id: HP:0002143 +name: Abnormality of the spinal cord +namespace: human_phenotype +def: "An abnormality of the spinal cord (myelon)." [HPO:probinson] +synonym: "Abnormality of the spinal cord" EXACT layperson [] +synonym: "Spinal cord disease" RELATED layperson [] +synonym: "Spinal cord pathology" RELATED [] +xref: MSH:D013118 +xref: SNOMEDCT_US:48522003 +xref: UMLS:C0037928 +xref: UMLS:C4025722 +is_a: HP:0002011 ! Morphological central nervous system abnormality + +[Term] +id: HP:0002145 +name: Frontotemporal dementia +namespace: human_phenotype +def: "A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders." [HPO:probinson, PMID:24966676] +xref: MSH:D057180 +xref: SNOMEDCT_US:230270009 +xref: UMLS:C0338451 +is_a: HP:0000726 ! Dementia + +[Term] +id: HP:0002185 +name: Neurofibrillary tangles +namespace: human_phenotype +alt_id: HP:0003132 +alt_id: HP:0007070 +def: "Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form." [HPO:sdoelken] +synonym: "Neurofibrillary tangles composed of disordered microtubules in neurons" EXACT [] +synonym: "Paired helical filaments" EXACT [] +xref: MSH:D016874 +xref: SNOMEDCT_US:85775002 +xref: UMLS:C0085400 +is_a: HP:0100314 ! Cerebral inclusion bodies + +[Term] +id: HP:0002186 +name: Apraxia +namespace: human_phenotype +def: "A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." [HPO:probinson] +synonym: "Apraxias" RELATED [] +xref: MSH:D001072 +xref: SNOMEDCT_US:68345001 +xref: SNOMEDCT_US:6950007 +xref: UMLS:C0003635 +is_a: HP:0011442 ! Abnormal central motor function +is_a: HP:0011446 ! Abnormality of higher mental function + +[Term] +id: HP:0002204 +name: Pulmonary embolism +namespace: human_phenotype +def: "An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery." [] +synonym: "Blood clot in artery of lung" EXACT layperson [ORCID:0000-0002-6548-5200] +xref: MSH:D011655 +xref: SNOMEDCT_US:59282003 +xref: UMLS:C0034065 +is_a: HP:0030875 ! Abnormality of pulmonary circulation + +[Term] +id: HP:0002257 +name: Chronic rhinitis +namespace: human_phenotype +def: "Chronic inflammation of the nasal mucosa." [HPO:probinson] +xref: SNOMEDCT_US:86094006 +xref: UMLS:C0008711 +is_a: HP:0012384 ! Rhinitis + +[Term] +id: HP:0002270 +name: Abnormality of the autonomic nervous system +namespace: human_phenotype +def: "An abnormality of the autonomic nervous system." [HPO:probinson] +comment: The autonomic nervous system is the part of the peripheral nervous system that controls visceral functions such as heart rate and digestion and functions largely below the level of consciousness. +xref: UMLS:C4025714 +is_a: HP:0410008 ! Abnormality of the peripheral nervous system + +[Term] +id: HP:0002315 +name: Headache +namespace: human_phenotype +alt_id: HP:0000266 +alt_id: HP:0001354 +def: "Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve." [HPO:probinson, PMID:15304572] +comment: Headache is one of the most common types of recurrent pain as well as one of the most frequent symptoms in neurology. In addition to occasional headaches, there are well-defined headache disorders that vary in incidence, prevalence and duration and can be divided into two broad categories. In secondary headache disorders, headaches are attributed to another condition, such as brain tumour or head injury; for the primary disorders the headache is not due to another condition. +synonym: "Headache" EXACT layperson [] +synonym: "Headaches" EXACT layperson [] +xref: MSH:D006261 +xref: SNOMEDCT_US:25064002 +xref: UMLS:C0018681 +is_a: HP:0012638 ! Abnormal nervous system physiology + +[Term] +id: HP:0002450 +name: Abnormal motor neuron morphology +namespace: human_phenotype +def: "Any structural anomaly that affects the motor neuron." [] +synonym: "Abnormal shape of motor neuron" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: UMLS:C4025707 +is_a: HP:0012757 ! Abnormal neuron morphology + +[Term] +id: HP:0002503 +name: Spinocerebellar tract degeneration +namespace: human_phenotype +synonym: "Degeneration of the spinocerebellar tracts" EXACT [] +synonym: "Spinocerebellar degeneration" EXACT [] +xref: UMLS:C1866751 +is_a: HP:0003133 ! Abnormality of the spinocerebellar tracts + +[Term] +id: HP:0002524 +name: Cataplexy +namespace: human_phenotype +alt_id: HP:0002428 +alt_id: HP:0002525 +def: "A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions." [HPO:probinson, PMID:21931493, PMID:22249574] +comment: Cataplexy is a frequent feature of narcolepsy, a neurologic disorder characterized by excessive daytime sleepiness and manifestations of disrupted rapid eye movement sleep stage. +xref: MSH:D002385 +xref: SNOMEDCT_US:46263000 +xref: UMLS:C0007384 +is_a: HP:0011442 ! Abnormal central motor function + +[Term] +id: HP:0002597 +name: Abnormality of the vasculature +namespace: human_phenotype +def: "An abnormality of the vasculature." [HPO:probinson] +synonym: "Abnormality of blood vessels" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of the vasculature" EXACT layperson [] +synonym: "Vascular abnormalities" EXACT layperson [] +xref: UMLS:C0241657 +is_a: HP:0001626 ! Abnormality of the cardiovascular system + +[Term] +id: HP:0002715 +name: Abnormality of the immune system +namespace: human_phenotype +alt_id: HP:0003257 +alt_id: HP:0003346 +alt_id: HP:0010986 +def: "An abnormality of the immune system." [HPO:probinson] +comment: The immune system is composed of organs and interdependent cell types that collectively protect the body from infections and from the growth of tumor cells. The organs of the immune system comprise the bone marrow, the spleen, the thymus,the lymph nodes, and the cell types comprise B cells, T cells, natural killer cells, granulocytes,dendritic cells, and macrophages. +synonym: "Abnormality of the immune system" EXACT layperson [] +synonym: "Immunological abnormality" EXACT layperson [] +xref: UMLS:C4021753 +is_a: HP:0000118 ! Phenotypic abnormality + +[Term] +id: HP:0002719 +name: Recurrent infections +namespace: human_phenotype +alt_id: HP:0002957 +alt_id: HP:0002964 +alt_id: HP:0005405 +def: "Increased susceptibility to infections." [HPO:probinson, HPO:skoehler] +synonym: "Frequent infections" EXACT layperson [] +synonym: "Frequent, severe infections" EXACT layperson [] +synonym: "Increased frequency of infection" EXACT layperson [] +synonym: "infections, recurrent" EXACT layperson [HPO:skoehler] +synonym: "Predisposition to infections" EXACT layperson [] +synonym: "Recurrent infections" EXACT layperson [] +synonym: "Susceptibility to infection" EXACT layperson [] +xref: UMLS:C0239998 +is_a: HP:0032101 ! Unusual infection + +[Term] +id: HP:0002725 +name: Systemic lupus erythematosus +namespace: human_phenotype +def: "A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." [HPO:probinson] +comment: This is a bundled term that describes a disease rather than a phenotypic feature, but is left for convenience for annotations of lupus conceived of as a feature of another disease. +synonym: "SLE" EXACT abbreviation [] +xref: MSH:D008180 +xref: SNOMEDCT_US:55464009 +xref: UMLS:C0024141 +is_a: HP:0002960 ! Autoimmunity + +[Term] +id: HP:0002754 +name: Osteomyelitis +namespace: human_phenotype +alt_id: HP:0002755 +alt_id: HP:0005901 +def: "Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism." [HPO:probinson, PMID:15276398] +comment: Osteomyelitis can be acute or chronic and can be caused by a variety of microbial agents. +synonym: "Bone infection" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: MSH:D010019 +xref: SNOMEDCT_US:111253001 +xref: SNOMEDCT_US:60168000 +xref: UMLS:C0029443 +xref: UMLS:C2242472 +is_a: HP:0011843 ! Abnormality of musculoskeletal physiology +is_a: HP:0012649 ! Increased inflammatory response + +[Term] +id: HP:0002795 +name: Abnormal respiratory system physiology +namespace: human_phenotype +synonym: "Abnormal respiration" EXACT [ORCID:0000-0001-5208-3432] +synonym: "Functional respiratory abnormality" EXACT layperson [] +synonym: "Respiratory problem" RELATED layperson [] +xref: Fyler:4200 +xref: UMLS:C4025677 +is_a: HP:0002086 ! Abnormality of the respiratory system + +[Term] +id: HP:0002829 +name: Arthralgia +namespace: human_phenotype +def: "Joint pain." [HPO:probinson] +comment: Arthralgia is distinct from Arthritis, which is not a symptom but a diagnosis with articular inflammation or signs of osteoarthritis. +synonym: "Arthralgias" EXACT [] +synonym: "Arthritic pain" RELATED [] +synonym: "Joint pain" EXACT layperson [ORCID:0000-0002-6548-5200] +synonym: "Joint pains" RELATED layperson [HPO:skoehler] +xref: MSH:D018771 +xref: SNOMEDCT_US:57676002 +xref: UMLS:C0003862 +is_a: HP:0012531 ! Pain + +[Term] +id: HP:0002960 +name: Autoimmunity +namespace: human_phenotype +def: "The occurrence of an immune reaction against the organism's own cells or tissues." [HPO:probinson] +synonym: "Autoimmune condition" EXACT [] +synonym: "Autoimmune disease" EXACT layperson [] +synonym: "Autoimmune disorder" EXACT layperson [] +synonym: "Autoimmunity" EXACT layperson [] +xref: MSH:D001327 +xref: SNOMEDCT_US:85828009 +xref: UMLS:C0004364 +is_a: HP:0010978 ! Abnormality of immune system physiology + +[Term] +id: HP:0002977 +name: Aplasia/Hypoplasia involving the central nervous system +namespace: human_phenotype +alt_id: HP:0001323 +def: "Absence or underdevelopment of tissue in the central nervous system." [HPO:probinson] +synonym: "Absent/underdeveloped central nervous system tissue" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Aplasia/Hypoplasia involving the CNS" EXACT abbreviation [] +xref: UMLS:C4025665 +is_a: HP:0002011 ! Morphological central nervous system abnormality +created_by: peter +creation_date: 2008-03-31T05:13:00Z + +[Term] +id: HP:0003011 +name: Abnormality of the musculature +namespace: human_phenotype +alt_id: HP:0003197 +alt_id: HP:0003708 +alt_id: HP:0040290 +def: "Abnormality originating in one or more muscles, i.e., of the set of muscles of body." [HPO:probinson] +synonym: "Muscular abnormality" EXACT layperson [] +xref: UMLS:C4021745 +is_a: HP:0033127 ! Abnormality of the musculoskeletal system + +[Term] +id: HP:0003074 +name: Hyperglycemia +namespace: human_phenotype +def: "An increased concentration of glucose in the blood." [HPO:probinson] +synonym: "High blood glucose" EXACT [ORCID:0000-0001-6908-9849] +synonym: "High blood sugar" EXACT layperson [ORCID:0000-0001-6908-9849] +xref: MSH:D006943 +xref: SNOMEDCT_US:237598005 +xref: SNOMEDCT_US:80394007 +xref: UMLS:C0020456 +is_a: HP:0011015 ! Abnormal blood glucose concentration + +[Term] +id: HP:0003077 +name: Hyperlipidemia +namespace: human_phenotype +alt_id: HP:0008159 +alt_id: HP:0008356 +def: "An elevated lipid concentration in the blood." [HPO:probinson] +comment: Hyperlipidemia is an elevation of the blood levels of lipids including primarily cholesterol, phospholipids and triglycerides and cholesterol esters. The lipids are transported on lipoproteins some of which are commonly used for clinical measurements, including chylomicrons, very-low density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins, and high-density lipoproteins (HDL). +synonym: "Elevated lipids in blood" EXACT layperson [https://orcid.org/0000-0002-6548-5200] +xref: MSH:D006949 +xref: SNOMEDCT_US:55822004 +xref: UMLS:C0020473 +is_a: HP:0003119 ! Abnormal circulating lipid concentration + +[Term] +id: HP:0003117 +name: Abnormal circulating hormone concentration +namespace: human_phenotype +def: "An abnormal concentration of a hormone in the blood." [HPO:probinson] +synonym: "Abnormal circulating hormone level" EXACT [] +synonym: "Abnormality of circulating hormone level" EXACT layperson [] +xref: UMLS:C4025652 +is_a: HP:0000818 ! Abnormality of the endocrine system + +[Term] +id: HP:0003119 +name: Abnormal circulating lipid concentration +namespace: human_phenotype +alt_id: HP:0003611 +def: "Any deviation from the normal concentration of a lipid in the blood circulation." [HPO:probinson] +comment: According to CHEBI:18059 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. +synonym: "Dyslipidaemia" RELATED uk_spelling [] +synonym: "Dyslipidemia" RELATED [] +xref: MSH:D050171 +xref: SNOMEDCT_US:370992007 +xref: UMLS:C0242339 +xref: UMLS:C4025650 +is_a: HP:0032180 ! Abnormal circulating metabolite concentration + +[Term] +id: HP:0003133 +name: Abnormality of the spinocerebellar tracts +namespace: human_phenotype +def: "An abnormality of the spinocerebellar tracts, a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. The spinocerebellar tract convey information to the cerebellum about limb and joint position (proprioception). They comprise the ventral spinocerebellar tract, the anterior spinocerebellar tract, and the posterior spinocerebellar tract." [HPO:probinson] +xref: UMLS:C4025647 +is_a: HP:0002143 ! Abnormality of the spinal cord + +[Term] +id: HP:0003198 +name: Myopathy +namespace: human_phenotype +alt_id: HP:0003569 +alt_id: HP:0003705 +alt_id: HP:0003742 +alt_id: HP:0003802 +def: "A disorder of muscle unrelated to impairment of innervation or neuromuscular junction." [HPO:probinson] +comment: The diagnosis of myopathy is often confirmed on the basis of myopathic changes in muscle biopsy. +synonym: "Muscle tissue disease" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Myopathic changes" EXACT [] +xref: MSH:D009135 +xref: SNOMEDCT_US:129565002 +xref: UMLS:C0026848 +is_a: HP:0011805 ! Abnormal skeletal muscle morphology + +[Term] +id: HP:0003674 +name: Onset +namespace: human_phenotype +alt_id: HP:0003588 +alt_id: HP:0003590 +alt_id: HP:0003597 +alt_id: HP:0003602 +alt_id: HP:0003603 +alt_id: HP:0003618 +alt_id: HP:0003626 +alt_id: HP:0003628 +alt_id: HP:0003630 +alt_id: HP:0003663 +alt_id: HP:0003664 +alt_id: HP:0003668 +alt_id: HP:0011007 +def: "The age group in which disease manifestations appear." [HPO:probinson] +comment: Adolescent is defined by WHO as a person between 10-19 years of age. +synonym: "Age of onset" EXACT [] +synonym: "Age symptoms begin" EXACT layperson [ORCID:0000-0002-6548-5200] +xref: MSH:D017668 +xref: UMLS:C0206132 +is_a: HP:0031797 ! Clinical course +is_a: PATO:0000001 ! quality + +[Term] +id: HP:0004323 +name: Abnormality of body weight +namespace: human_phenotype +alt_id: HP:0010718 +def: "An abnormal increase or decrease of weight or an abnormal distribution of mass in the body." [HPO:probinson] +synonym: "Abnormality of body weight" EXACT layperson [] +synonym: "Abnormality of habitus" RELATED [] +xref: UMLS:C0878621 +xref: UMLS:C4025357 +is_a: HP:0001507 ! Growth abnormality +created_by: peter +creation_date: 2008-02-27T03:21:00Z + +[Term] +id: HP:0004325 +name: Decreased body weight +namespace: human_phenotype +alt_id: HP:0001823 +alt_id: HP:0001826 +def: "Abnormally low body weight." [] +synonym: "Decreased body weight" EXACT layperson [] +synonym: "Decreased weight" EXACT layperson [] +synonym: "Low body weight" EXACT layperson [] +synonym: "Low weight" EXACT layperson [] +synonym: "Weight less than 3rd percentile" EXACT layperson [] +xref: MSH:D013851 +xref: MSH:D015431 +xref: SNOMEDCT_US:161832001 +xref: SNOMEDCT_US:248342006 +xref: SNOMEDCT_US:262285001 +xref: SNOMEDCT_US:89362005 +xref: UMLS:C0041667 +xref: UMLS:C1262477 +xref: UMLS:C1844806 +is_a: HP:0004323 ! Abnormality of body weight +created_by: peter +creation_date: 2008-02-27T03:22:00Z + +[Term] +id: HP:0004340 +name: Abnormality of vitamin B metabolism +namespace: human_phenotype +synonym: "Abnormality of B-vitamin metabolism" EXACT [] +xref: UMLS:C4021659 +is_a: HP:0100508 ! Abnormality of vitamin metabolism +created_by: peter +creation_date: 2008-03-08T08:08:00Z + +[Term] +id: HP:0004341 +name: Abnormality of vitamin B12 metabolism +namespace: human_phenotype +synonym: "Abnormality of the vitamin B12 metabolism" EXACT [] +xref: UMLS:C4021658 +is_a: HP:0004340 ! Abnormality of vitamin B metabolism +created_by: peter +creation_date: 2008-03-08T08:09:00Z + +[Term] +id: HP:0006476 +name: Abnormality of the pancreatic islet cells +namespace: human_phenotype +alt_id: HP:0100567 +def: "An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin." [HPO:probinson] +xref: UMLS:C4025043 +is_a: HP:0012093 ! Abnormality of endocrine pancreas physiology +created_by: peter +creation_date: 2008-03-28T04:41:00Z + +[Term] +id: HP:0006530 +name: Abnormal pulmonary interstitial morphology +namespace: human_phenotype +alt_id: HP:0006513 +alt_id: HP:0006547 +def: "Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis." [HPO:probinson] +synonym: "Abnormal lung parenchyma morphology" EXACT [] +synonym: "Abnormality in area between air sacs in lung" EXACT layperson [https://orcid.org/0000-0002-6548-5200] +synonym: "Interstitial lung disease" EXACT [] +synonym: "Interstitial pulmonary disease" EXACT [] +xref: MSH:D017563 +xref: SNOMEDCT_US:233703007 +xref: UMLS:C0206062 +is_a: HP:0002088 ! Abnormal lung morphology + +[Term] +id: HP:0007313 +name: Cerebral degeneration +namespace: human_phenotype +alt_id: HP:0006874 +synonym: "Neuroaxonal degeneration in the brain" EXACT [] +xref: SNOMEDCT_US:418143002 +xref: SNOMEDCT_US:52522001 +xref: UMLS:C0154671 +is_a: HP:0007369 ! Atrophy/Degeneration affecting the cerebrum + +[Term] +id: HP:0007354 +name: Amyotrophic lateral sclerosis +namespace: human_phenotype +synonym: "Lou Gehrig's disease" RELATED layperson [ORCID:0000-0001-5208-3432] +xref: MSH:D000690 +xref: SNOMEDCT_US:86044005 +xref: UMLS:C0002736 +is_a: HP:0007373 ! Motor neuron atrophy + +[Term] +id: HP:0007367 +name: Atrophy/Degeneration affecting the central nervous system +namespace: human_phenotype +synonym: "Atrophy/Degeneration affecting the CNS" EXACT abbreviation [] +xref: UMLS:C4024899 +is_a: HP:0002011 ! Morphological central nervous system abnormality +created_by: peter +creation_date: 2008-04-01T10:23:00Z + +[Term] +id: HP:0007369 +name: Atrophy/Degeneration affecting the cerebrum +namespace: human_phenotype +def: "The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain." [HPO:probinson] +xref: UMLS:C4024898 +is_a: HP:0002060 ! Abnormal cerebral morphology +is_a: HP:0002977 ! Aplasia/Hypoplasia involving the central nervous system +is_a: HP:0012444 ! Brain atrophy +created_by: peter +creation_date: 2008-04-01T10:28:00Z + +[Term] +id: HP:0007373 +name: Motor neuron atrophy +namespace: human_phenotype +def: "Wasting involving the motor neuron." [HPO:probinson] +synonym: "Motor neuron degeneration" EXACT [ORCID:0000-0001-5208-3432] +xref: UMLS:C4024896 +is_a: HP:0002450 ! Abnormal motor neuron morphology +is_a: HP:0007367 ! Atrophy/Degeneration affecting the central nervous system +created_by: peter +creation_date: 2008-04-01T10:39:00Z + +[Term] +id: HP:0010606 +name: Hordeolum +namespace: human_phenotype +def: "An acute purulent infection of the sebaceous glands of Zeis at the base of the eyelashes, of the apocrine sweat glands of Moll or the meibomian sebacious glands often caused by staphylococcus infections. Hordeola can either occur as Hordeola externa affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll or as Hordeola interna affecting the meibomian sebacious glands. In contrast to chalazia, hordeola are extremely painful and can cause extreme local swelling." [HPO:sdoelken] +synonym: "Red bump on eyelid" RELATED layperson [ORCID:0000-0001-5889-4463] +synonym: "Stye of eyelid" EXACT layperson [ORCID:0000-0001-5889-4463] +xref: MSH:D006726 +xref: SNOMEDCT_US:1489008 +xref: SNOMEDCT_US:397513003 +xref: UMLS:C0019917 +xref: UMLS:C4280376 +is_a: HP:0010732 ! Nodular changes affecting the eyelids +created_by: sandra1 +creation_date: 2009-10-27T11:01:13Z + +[Term] +id: HP:0010732 +name: Nodular changes affecting the eyelids +namespace: human_phenotype +def: "Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more." [HPO:sdoelken] +synonym: "Eyelid nodules" EXACT layperson [ORCID:0000-0001-5889-4463] +xref: UMLS:C4023716 +is_a: HP:0000492 ! Abnormal eyelid morphology +is_a: HP:0200036 ! Skin nodule +created_by: doelkens +creation_date: 2010-04-21T05:11:04Z + +[Term] +id: HP:0010935 +name: Abnormality of the upper urinary tract +namespace: human_phenotype +def: "An abnormality of the upper urinary tract." [HPO:probinson] +comment: The upper urinary tract is a subdivision of urinary system which consists of the kidney and the ureters. +synonym: "Abnormality of the upper urinary tract" EXACT layperson [] +xref: UMLS:C4023641 +is_a: HP:0000079 ! Abnormality of the urinary system +created_by: peter +creation_date: 2011-01-16T11:37:29Z + +[Term] +id: HP:0010978 +name: Abnormality of immune system physiology +namespace: human_phenotype +def: "A functional abnormality of the immune system." [HPO:probinson, MP:0001790] +xref: UMLS:C4023616 +is_a: HP:0002715 ! Abnormality of the immune system +created_by: peter +creation_date: 2011-02-07T04:28:55Z + +[Term] +id: HP:0011014 +name: Abnormal glucose homeostasis +namespace: human_phenotype +def: "Abnormality of glucose homeostasis." [HPO:probinson] +comment: An abnormality of any process involved in the maintenance of an internal steady state of glucose within an organism or cell. +xref: UMLS:C4023598 +is_a: HP:0012337 ! Abnormal homeostasis +created_by: peter +creation_date: 2011-02-21T10:37:21Z + +[Term] +id: HP:0011015 +name: Abnormal blood glucose concentration +namespace: human_phenotype +def: "An abnormality of the concentration of glucose in the blood." [HPO:probinson] +synonym: "Abnormality of blood glucose concentration" EXACT [] +xref: UMLS:C4023597 +is_a: HP:0011014 ! Abnormal glucose homeostasis +created_by: peter +creation_date: 2011-02-21T10:41:13Z + +[Term] +id: HP:0011025 +name: Abnormal cardiovascular system physiology +namespace: human_phenotype +def: "Abnormal functionality of the cardiovascular system." [HPO:probinson] +synonym: "Abnormality of cardiovascular system physiology" EXACT [] +xref: UMLS:C4023587 +is_a: HP:0001626 ! Abnormality of the cardiovascular system +created_by: peter +creation_date: 2011-03-03T10:23:19Z + +[Term] +id: HP:0011032 +name: Abnormality of fluid regulation +namespace: human_phenotype +def: "An abnormality of the regulation of body fluids." [HPO:probinson] +synonym: "Abnormality of fluid regulation" EXACT layperson [] +synonym: "Fluid imbalance" EXACT layperson [ORCID:0000-0001-6908-9849] +xref: SNOMEDCT_US:1860003 +xref: SNOMEDCT_US:190902006 +xref: UMLS:C2364164 +is_a: HP:0012337 ! Abnormal homeostasis +created_by: peter +creation_date: 2011-03-05T09:09:27Z + +[Term] +id: HP:0011035 +name: Abnormal renal cortex morphology +namespace: human_phenotype +def: "An abnormality of the cortex of the kidney." [HPO:probinson] +synonym: "Abnormality of renal cortex morphology" EXACT [] +xref: UMLS:C4023580 +is_a: HP:0012210 ! Abnormal renal morphology +created_by: peter +creation_date: 2011-03-06T11:31:39Z + +[Term] +id: HP:0011043 +name: Abnormality of circulating adrenocorticotropin level +namespace: human_phenotype +def: "An abnormal concentration of corticotropin in the blood." [HPO:probinson] +comment: Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. . It is a component of the hypothalamic-pituitary-adrenal axis and stimulates increased production and release of corticosteroids and cortisol from the adrenal cortex. +synonym: "Abnormality of circulating ACTH level" RELATED abbreviation [] +synonym: "Abnormality of circulating adrenocorticotropic hormone level" RELATED [] +synonym: "Abnormality of circulating adrenocorticotropin level" RELATED [] +synonym: "Abnormality of circulating corticotropin level" EXACT [] +xref: UMLS:C4023574 +is_a: HP:0003117 ! Abnormal circulating hormone concentration +created_by: peter +creation_date: 2011-03-10T07:46:59Z + +[Term] +id: HP:0011110 +name: Recurrent tonsillitis +namespace: human_phenotype +def: "Inflammation of the tonsils that has occurred repeatedly. The definition of recurrent may vary somewhat, but the criteria used recently as a measure of severity were five or more episodes of true tonsillitis per year, symptoms recurring for at least a year, and episodes that are disabling and that prevent normal functioning. In some cases recurrent tonsillitis may be related to immunosusceptibility. Evidence exists for a genetic predisposition for recurrent tonsillitis." [HPO:probinson, PMID:15897415] +synonym: "IRecurrent inflammation of tonsils" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: MSH:D014069 +xref: SNOMEDCT_US:90176007 +xref: UMLS:C0040425 +is_a: HP:0002719 ! Recurrent infections +is_a: HP:0100765 ! Abnormality of the tonsils +created_by: peter +creation_date: 2011-06-10T07:46:38Z + +[Term] +id: HP:0011121 +name: Abnormality of skin morphology +namespace: human_phenotype +def: "Any morphological abnormality of the skin." [HPO:probinson] +synonym: "Abnormal skin morphology" EXACT [ORCID:0000-0001-5208-3432] +synonym: "Abnormal skin structure" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: Fyler:4133 +xref: UMLS:C4023528 +is_a: HP:0000951 ! Abnormality of the skin +created_by: peter +creation_date: 2011-06-12T10:03:23Z + +[Term] +id: HP:0011122 +name: Abnormality of skin physiology +namespace: human_phenotype +def: "Any abnormality of the physiological function of the skin." [HPO:probinson] +synonym: "Abnormality of skin physiology" EXACT layperson [] +xref: UMLS:C4023527 +is_a: HP:0000951 ! Abnormality of the skin +created_by: peter +creation_date: 2011-06-12T10:05:14Z + +[Term] +id: HP:0011123 +name: Inflammatory abnormality of the skin +namespace: human_phenotype +alt_id: HP:0002727 +alt_id: HP:0007423 +def: "The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes." [HPO:probinson] +synonym: "Abnormal tendency to infections of the skin" EXACT [] +synonym: "Dermatitis" RELATED [] +synonym: "Inflammatory abnormality of the skin" EXACT layperson [] +synonym: "Inflammatory skin disease" RELATED [] +synonym: "Skin inflammation" EXACT layperson [] +xref: MP:0004947 +xref: MSH:D003872 +xref: SNOMEDCT_US:703938007 +xref: UMLS:C0011603 +xref: UMLS:C3875321 +is_a: HP:0011122 ! Abnormality of skin physiology +is_a: HP:0012649 ! Increased inflammatory response +created_by: peter +creation_date: 2011-06-12T10:06:04Z + +[Term] +id: HP:0011277 +name: Abnormality of the urinary system physiology +namespace: human_phenotype +xref: UMLS:C4023437 +is_a: HP:0000079 ! Abnormality of the urinary system +created_by: peter +creation_date: 2011-12-30T02:51:16Z + +[Term] +id: HP:0011355 +name: Localized skin lesion +namespace: human_phenotype +def: "A lesion of the skin that is located in a specific region rather than being generalized." [DDD:cmoss] +synonym: "Localised skin lesion" EXACT uk_spelling [] +synonym: "Localized skin lesion" EXACT layperson [] +xref: UMLS:C0850826 +is_a: HP:0011121 ! Abnormality of skin morphology +created_by: peter +creation_date: 2012-03-01T02:37:43Z + +[Term] +id: HP:0011442 +name: Abnormal central motor function +namespace: human_phenotype +def: "An anomaly of the control or production of movement in the central nervous system." [HPO:probinson] +synonym: "Abnormality of central motor function" EXACT [] +xref: UMLS:C4023354 +is_a: HP:0012638 ! Abnormal nervous system physiology +created_by: peter +creation_date: 2012-03-18T02:29:04Z + +[Term] +id: HP:0011443 +name: Abnormality of coordination +namespace: human_phenotype +synonym: "Abnormality of coordination" EXACT layperson [] +synonym: "Coordination issue" EXACT layperson [] +xref: UMLS:C4023353 +is_a: HP:0011442 ! Abnormal central motor function +created_by: peter +creation_date: 2012-03-18T02:40:46Z + +[Term] +id: HP:0011446 +name: Abnormality of higher mental function +namespace: human_phenotype +def: "Cognitive, psychiatric or memory anomaly." [DDD:ajackson] +xref: UMLS:C4023352 +is_a: HP:0012638 ! Abnormal nervous system physiology +created_by: peter +creation_date: 2012-03-18T04:23:59Z + +[Term] +id: HP:0011450 +name: Unusual CNS infection +namespace: human_phenotype +def: "A type of infection of the central nervous system that can be regarded as a sign of a pathological susceptibility to infection." [] +synonym: "Central nervous system infection" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: MSH:D002494 +xref: SNOMEDCT_US:128117002 +xref: UMLS:C0007684 +is_a: HP:0002011 ! Morphological central nervous system abnormality +is_a: HP:0032158 ! Unusual infection by anatomical site +created_by: peter +creation_date: 2012-03-18T05:57:29Z + +[Term] +id: HP:0011458 +name: Abdominal symptom +namespace: human_phenotype +def: "A subjective manifestation of disease localized to the abdomen." [] +xref: UMLS:C0740651 +is_a: HP:0025032 ! Abnormality of digestive system physiology +created_by: peter +creation_date: 2012-03-25T05:35:45Z + +[Term] +id: HP:0011463 +name: Childhood onset +namespace: human_phenotype +alt_id: HP:0003586 +alt_id: HP:0003617 +def: "Onset of disease at the age of between 1 and 5 years." [DDD:hfirth] +comment: This term refers to ages up to but not including the fifth birthday (see Juvenile onset). +synonym: "Symptoms begin in childhood" EXACT layperson [orcid.org/0000-0002-6548-5200] +xref: UMLS:C1837352 +is_a: HP:0410280 ! Pediatric onset +created_by: peter +creation_date: 2012-03-25T07:16:20Z + +[Term] +id: HP:0011747 +name: Abnormality of the anterior pituitary +namespace: human_phenotype +def: "An abnormality of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland." [DDD:spark] +synonym: "Pituitary disease" RELATED [] +xref: MSH:D010900 +xref: SNOMEDCT_US:399244003 +xref: UMLS:C0032002 +xref: UMLS:C4023206 +is_a: HP:0012503 ! Abnormality of the pituitary gland +created_by: peter +creation_date: 2012-04-22T11:17:00Z + +[Term] +id: HP:0011805 +name: Abnormal skeletal muscle morphology +namespace: human_phenotype +alt_id: HP:0003735 +def: "A structural abnormality of a skeletal muscle." [HPO:probinson] +synonym: "Abnormal muscle morphology" EXACT [] +synonym: "Abnormality of muscle morphology" EXACT [] +synonym: "Abnormally shaped muscle" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Issue with muscle structure" EXACT layperson [] +xref: UMLS:C4023181 +is_a: HP:0003011 ! Abnormality of the musculature +created_by: peter +creation_date: 2012-04-25T02:00:34Z + +[Term] +id: HP:0011842 +name: Abnormality of skeletal morphology +namespace: human_phenotype +def: "An abnormality of the form, structure, or size of the skeletal system." [HPO:probinson] +synonym: "Abnormally shaped skeletal" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: UMLS:C4023165 +is_a: HP:0000924 ! Abnormality of the skeletal system +created_by: peter +creation_date: 2012-05-07T08:08:37Z + +[Term] +id: HP:0011843 +name: Abnormality of musculoskeletal physiology +namespace: human_phenotype +def: "An abnormality of the function of the skeletal system." [HPO:probinson] +xref: UMLS:C4023164 +is_a: HP:0000924 ! Abnormality of the skeletal system +created_by: peter +creation_date: 2012-05-07T08:09:43Z + +[Term] +id: HP:0011947 +name: Respiratory tract infection +namespace: human_phenotype +def: "An infection of the upper or lower respiratory tract." [HPO:probinson] +synonym: "Respiratory infection" EXACT layperson [] +synonym: "Respiratory infections" RELATED layperson [HPO:skoehler] +synonym: "Respiratory tract infection" EXACT layperson [] +xref: MSH:D012141 +xref: SNOMEDCT_US:275498002 +xref: UMLS:C0035243 +is_a: HP:0002088 ! Abnormal lung morphology +created_by: peter +creation_date: 2012-06-21T08:26:36Z + +[Term] +id: HP:0012091 +name: Abnormality of pancreas physiology +namespace: human_phenotype +def: "An anomaly of the function of the pancreas." [HPO:probinson] +xref: UMLS:C4023048 +is_a: HP:0001732 ! Abnormality of the pancreas +created_by: peter +creation_date: 2012-08-20T09:17:10Z + +[Term] +id: HP:0012093 +name: Abnormality of endocrine pancreas physiology +namespace: human_phenotype +def: "A function abnormality of the endocrine pancreas." [HPO:probinson] +xref: UMLS:C4023047 +is_a: HP:0000818 ! Abnormality of the endocrine system +is_a: HP:0012091 ! Abnormality of pancreas physiology +created_by: peter +creation_date: 2012-08-20T09:18:18Z + +[Term] +id: HP:0012210 +name: Abnormal renal morphology +namespace: human_phenotype +alt_id: HP:0000792 +alt_id: HP:0004726 +alt_id: HP:0004735 +alt_id: HP:0008712 +def: "Any structural anomaly of the kidney." [HPO:probinson] +synonym: "Abnormal kidney morphology" EXACT [ORCID:0000-0001-5208-3432] +synonym: "Abnormally shaped kidney" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Kidney malformation" EXACT layperson [] +synonym: "Kidney structure issue" EXACT layperson [] +synonym: "Renal malformation" EXACT [] +synonym: "Structural anomalies of the renal tract" EXACT [] +synonym: "Structural kidney abnormalities" EXACT layperson [] +synonym: "Structural renal anomalies" EXACT [] +xref: Fyler:4512 +xref: SNOMEDCT_US:44513007 +xref: UMLS:C0266292 +is_a: HP:0000077 ! Abnormality of the kidney +created_by: peter +creation_date: 2013-03-14T07:41:11Z + +[Term] +id: HP:0012211 +name: Abnormal renal physiology +namespace: human_phenotype +alt_id: HP:0000082 +alt_id: HP:0000087 +alt_id: HP:0005566 +alt_id: HP:0008646 +def: "An abnormal functionality of the kidney." [HPO:probinson] +synonym: "Abnormal kidney function" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormal renal function" EXACT [HPO:skoehler] +synonym: "Abnormality of renal physiology" EXACT [] +synonym: "Kidney function issue" EXACT layperson [] +synonym: "Renal functional abnormality" EXACT [] +xref: SNOMEDCT_US:39539005 +xref: UMLS:C0151746 +is_a: HP:0000077 ! Abnormality of the kidney +is_a: HP:0011277 ! Abnormality of the urinary system physiology +created_by: peter +creation_date: 2013-03-14T07:43:34Z + +[Term] +id: HP:0012252 +name: Abnormal respiratory system morphology +namespace: human_phenotype +def: "A structural anomaly of the respiratory system." [HPO:probinson] +xref: Fyler:4235 +xref: UMLS:C4022992 +is_a: HP:0002086 ! Abnormality of the respiratory system +created_by: peter +creation_date: 2013-04-07T09:11:09Z + +[Term] +id: HP:0012332 +name: Abnormal autonomic nervous system physiology +namespace: human_phenotype +alt_id: HP:0002271 +alt_id: HP:0002387 +alt_id: HP:0002459 +alt_id: HP:0007310 +def: "A functional abnormality of the autonomic nervous system." [HPO:probinson] +synonym: "Autonomic dysfunction" EXACT [] +synonym: "Autonomic dysregulation" EXACT [] +synonym: "Dysautonomia" EXACT [] +xref: UMLS:C4022952 +is_a: HP:0002270 ! Abnormality of the autonomic nervous system +created_by: peter +creation_date: 2013-09-13T07:53:55Z + +[Term] +id: HP:0012337 +name: Abnormal homeostasis +namespace: human_phenotype +def: "An anomaly in the processes involved in the maintenance of an internal equilibrium." [HPO:probinson] +xref: MP:0001764 "Abnormal homeostasis" +xref: UMLS:C4022950 +is_a: HP:0001939 ! Abnormality of metabolism/homeostasis +created_by: peter +creation_date: 2013-09-13T09:23:23Z + +[Term] +id: HP:0012372 +name: Abnormal eye morphology +namespace: human_phenotype +alt_id: HP:0000489 +alt_id: HP:0012374 +def: "A structural anomaly of the globe of the eye, or bulbus oculi." [HPO:probinson] +comment: previously: Abnormal globe morphology +synonym: "Abnormal eye structure" EXACT layperson [] +synonym: "Abnormality of the globe" EXACT [] +synonym: "Abnormally shaped eye" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: Fyler:4863 +xref: UMLS:C4022925 +is_a: HP:0000478 ! Abnormality of the eye +created_by: peter +creation_date: 2013-10-13T03:44:43Z + +[Term] +id: HP:0012373 +name: Abnormal eye physiology +namespace: human_phenotype +def: "A functional anomaly of the eye." [HPO:probinson] +synonym: "Abnormal eye physiology" EXACT layperson [] +xref: UMLS:C4022924 +is_a: HP:0000478 ! Abnormality of the eye +created_by: peter +creation_date: 2013-10-13T03:45:37Z + +[Term] +id: HP:0012384 +name: Rhinitis +namespace: human_phenotype +def: "Inflammation of the nasal mucosa with nasal congestion." [HPO:probinson] +subset: hposlim_core +synonym: "Nasal inflammation" EXACT layperson [ORCID:0000-0001-5889-4463] +xref: MSH:D012220 +xref: SNOMEDCT_US:70076002 +xref: UMLS:C0035455 +xref: UMLS:C2718128 +is_a: HP:0000366 ! Abnormality of the nose +created_by: hecht +creation_date: 2013-10-19T05:37:08Z + +[Term] +id: HP:0012443 +name: Abnormality of brain morphology +namespace: human_phenotype +def: "A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain." [HPO:probinson] +synonym: "Abnormal shape of brain" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of the brain" EXACT layperson [] +xref: UMLS:C4021085 +is_a: HP:0002011 ! Morphological central nervous system abnormality +created_by: peter +creation_date: 2013-11-23T02:38:00Z + +[Term] +id: HP:0012444 +name: Brain atrophy +namespace: human_phenotype +def: "Partial or complete wasting (loss) of brain tissue that was once present." [HPO:probinson] +synonym: "Brain degeneration" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Brain wasting" EXACT layperson [ORCID:0000-0001-5208-3432] +xref: SNOMEDCT_US:278849000 +xref: SNOMEDCT_US:418143002 +xref: SNOMEDCT_US:52522001 +xref: UMLS:C0154671 +xref: UMLS:C0235946 +is_a: HP:0007367 ! Atrophy/Degeneration affecting the central nervous system +is_a: HP:0012443 ! Abnormality of brain morphology +created_by: peter +creation_date: 2013-11-23T02:46:15Z + +[Term] +id: HP:0012503 +name: Abnormality of the pituitary gland +namespace: human_phenotype +def: "An anomaly of the pituitary gland." [HPO:probinson] +synonym: "disorder of pituitary gland" EXACT [] +xref: MSH:D010900 +xref: SNOMEDCT_US:399244003 +xref: UMLS:C0032002 +is_a: HP:0000864 ! Abnormality of the hypothalamus-pituitary axis +is_a: HP:0012443 ! Abnormality of brain morphology +created_by: peter +creation_date: 2013-11-30T09:34:21Z + +[Term] +id: HP:0012531 +name: Pain +namespace: human_phenotype +def: "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." [ORCID:0000-0001-5208-3432] +synonym: "Pain" EXACT layperson [] +xref: MSH:D010146 +xref: SNOMEDCT_US:22253000 +xref: UMLS:C0030193 +is_a: HP:0025142 ! Constitutional symptom +created_by: peter +creation_date: 2013-12-15T09:38:08Z + +[Term] +id: HP:0012575 +name: Abnormal nephron morphology +namespace: human_phenotype +def: "A structural anomaly of the nephron." [Eurenomics:fschaefer] +synonym: "Abnormality of the nephron" EXACT [] +xref: UMLS:C4022838 +is_a: HP:0012210 ! Abnormal renal morphology +created_by: peter +creation_date: 2014-01-16T12:49:04Z + +[Term] +id: HP:0012638 +name: Abnormal nervous system physiology +namespace: human_phenotype +def: "A functional anomaly of the nervous system." [HPO:probinson] +synonym: "Abnormality of nervous system physiology" EXACT [] +xref: UMLS:C4022811 +is_a: HP:0000707 ! Abnormality of the nervous system +created_by: peter +creation_date: 2014-01-19T08:02:46Z + +[Term] +id: HP:0012639 +name: Abnormal nervous system morphology +namespace: human_phenotype +def: "A structural anomaly of the nervous system." [HPO:probinson] +synonym: "Abnormal nervous system morphology" EXACT [ORCID:0000-0001-5208-3432] +synonym: "Abnormal shape of nervous system" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of nervous system morphology" EXACT [] +xref: Fyler:4135 +xref: Fyler:4300 +xref: UMLS:C4022810 +is_a: HP:0000707 ! Abnormality of the nervous system +created_by: peter +creation_date: 2014-01-19T08:03:08Z + +[Term] +id: HP:0012647 +name: Abnormal inflammatory response +namespace: human_phenotype +def: "Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [MONARCH:mhaendel] +synonym: "Abnormal inflammatory response" EXACT layperson [] +xref: UMLS:C4022805 +is_a: HP:0010978 ! Abnormality of immune system physiology +created_by: peter +creation_date: 2014-02-01T01:25:42Z + +[Term] +id: HP:0012649 +name: Increased inflammatory response +namespace: human_phenotype +def: "A abnormal increase in the inflammatory response to injury or infection." [MONARCH:mhaendel] +xref: UMLS:C4022803 +is_a: HP:0012647 ! Abnormal inflammatory response +created_by: peter +creation_date: 2014-02-01T01:29:58Z + +[Term] +id: HP:0012735 +name: Cough +namespace: human_phenotype +def: "A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation." [HPO:probinson, PMID:16428719, PMID:17540788] +comment: The European Respiratory Society Task Force recommended two possible definitions of cough: (1) A three-phase expulsive motor act characterized by an inspiratory effort (inspiratory phase) followed by a forced expiratory effort against a closed glottis (compressive phase) and then by opening of the glottis and rapid expiratory airflow (expulsive phase);and (2) A forced expiratory manoeuvre, usually against a closed glottis and associated with a characteristic sound. The term Cough or any of its more specific descendents can be modified by the terms Acute (HP:0011009), Subacute (HP:0011011), and Chronic (HP:0011010). In adults, an acute cough lasts less than 3 weeks, a subacute cough from 3 to 8 weeks, and a chronic cough longer than 8 weeks. In children aged less than 15 years a chronic cough is defined as a daily cough lasting for over 4 weeks. +synonym: "Cough" EXACT layperson [] +synonym: "Coughing" EXACT layperson [] +xref: MSH:D003371 +xref: SNOMEDCT_US:263731006 +xref: SNOMEDCT_US:272039006 +xref: SNOMEDCT_US:49727002 +xref: UMLS:C0010200 +is_a: HP:0002795 ! Abnormal respiratory system physiology +created_by: peter +creation_date: 2014-03-23T03:19:50Z + +[Term] +id: HP:0012757 +name: Abnormal neuron morphology +namespace: human_phenotype +def: "A structural anomaly of a neuron." [KI:phemming] +synonym: "Abnormal neuron shape" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormal neuronal morphology" EXACT [] +xref: UMLS:C4022739 +is_a: HP:0012639 ! Abnormal nervous system morphology +created_by: peter +creation_date: 2014-04-02T05:12:30Z + +[Term] +id: HP:0012823 +name: Clinical modifier +namespace: human_phenotype +alt_id: HP:0000004 +def: "This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects." [HPO:probinson] +comment: Note that some of the terms, such as Intellectual disability, have children terms such as Severe intellectual disability that represent precomposed combinations of modifiers and phenotypic abnormality terms. This done where the medical community commonly uses these terms with a fixed meaning (for instance, the Intellectual disability terms are used with specific IQ ranges). For computational reasoning, the semantics are intended to be the same as if there was a combination of the phenotype term and the clinical modifier term. +synonym: "Phenotypic modifier" EXACT [] +xref: UMLS:C4021064 +is_a: HP:0000001 ! All +created_by: peter +creation_date: 2014-06-06T06:34:24Z + +[Term] +id: HP:0025031 +name: Abnormality of the digestive system +namespace: human_phenotype +comment: Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus. +is_a: HP:0000118 ! Phenotypic abnormality +property_value: http://purl.org/dc/elements/1.1/date 2016-08-27T13:44:32Z xsd:dateTime +created_by: HPO:probinson + +[Term] +id: HP:0025032 +name: Abnormality of digestive system physiology +namespace: human_phenotype +def: "A functional anomaly of the digestive system." [] +is_a: HP:0025031 ! Abnormality of the digestive system +property_value: http://purl.org/dc/elements/1.1/date 2016-08-27T13:58:05Z xsd:dateTime +created_by: HPO:probinson + +[Term] +id: HP:0025085 +name: Bloody diarrhea +namespace: human_phenotype +def: "Passage of many stools containing blood." [] +comment: Diarrhea that contains bright red or maroon-colored blood may be referred to as hematochezia, while melena is used to describe black, tarry, and smelly diarrhea. +synonym: "Blood in stool" BROAD layperson [] +synonym: "Bloody bowel movement" EXACT layperson [] +synonym: "Bloody diarrhea" EXACT layperson [] +synonym: "Bloody diarrhoea" EXACT layperson [] +synonym: "Bloody stool" BROAD layperson [] +is_a: HP:0002014 ! Diarrhea +property_value: http://purl.org/dc/elements/1.1/date 2016-10-15T13:58:14Z xsd:dateTime +created_by: HPO:probinson + +[Term] +id: HP:0025142 +name: Constitutional symptom +namespace: human_phenotype +def: "A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual." [] +comment: Note that we use the preferred term label constitutional symptom because this reflects common usage, but we do not restrict the term or its descendents to the narrow meaning of symptom, i.e., a complaint related by a patient to a physician. There is no generally accepted classification of what defines a constitutional symptom, but examples include weight loss, fatigue, general weakness, night sweats, shaking, chills, fever, and vomiting. +is_a: HP:0000118 ! Phenotypic abnormality +property_value: http://purl.org/dc/elements/1.1/date 2016-11-29T11:02:54Z xsd:dateTime +created_by: HPO:probinson + +[Term] +id: HP:0030163 +name: Abnormal vascular physiology +namespace: human_phenotype +def: "Abnormality of vascular function." [HPO:probinson] +xref: UMLS:C4022603 +is_a: HP:0002597 ! Abnormality of the vasculature +is_a: HP:0011025 ! Abnormal cardiovascular system physiology + +[Term] +id: HP:0030669 +name: Abnormal ocular adnexa morphology +namespace: human_phenotype +def: "A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." [] +xref: UMLS:C4073120 +is_a: HP:0032039 ! Abnormality of the ocular adnexa + +[Term] +id: HP:0030828 +name: Wheezing +namespace: human_phenotype +def: "A high-pitched whistling sound associated with labored breathing." [HPO:probinson, PMID:26229557] +comment: Wheezes and rhonchi are continuous musical lung sounds. The American Thoracic Society (ATS) Committee on pulmonary nomenclature defines wheezes as high-pitched continuous sounds with a dominant frequency of 400 Hz or more, and rhonchi as low-pitched continuous musical sounds with a dominant frequency of about 200 Hz or less +synonym: "Wheezing" EXACT layperson [] +xref: MSH:D012135 +xref: SNOMEDCT_US:56018004 +xref: UMLS:C0043144 +is_a: HP:0030829 ! Abnormal breath sound + +[Term] +id: HP:0030829 +name: Abnormal breath sound +namespace: human_phenotype +def: "An anomalous (adventitious) sound produced by the breathing process." [HPO:probinson] +xref: SNOMEDCT_US:301273002 +xref: UMLS:C0231856 +is_a: HP:0002795 ! Abnormal respiratory system physiology + +[Term] +id: HP:0030875 +name: Abnormality of pulmonary circulation +namespace: human_phenotype +def: "A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart." [HPO:probinson] +synonym: "Abnormal pulmonary circulation" EXACT [] +synonym: "Abnormality of respiratory circulation" EXACT [] +xref: UMLS:C4280730 +is_a: HP:0002795 ! Abnormal respiratory system physiology +is_a: HP:0030163 ! Abnormal vascular physiology + +[Term] +id: HP:0030972 +name: Abnormal systemic blood pressure +namespace: human_phenotype +def: "A chronic deviation from normal pressure in the systemic arterial system." [] +synonym: "Abnormal systemic BP" EXACT abbreviation [] +is_a: HP:0011025 ! Abnormal cardiovascular system physiology +property_value: http://purl.org/dc/elements/1.1/date 2017-04-18T13:55:40Z xsd:dateTime +created_by: robinp + +[Term] +id: HP:0031263 +name: Abnormal renal corpuscle morphology +namespace: human_phenotype +def: "Any anomolous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule." [] +is_a: HP:0011035 ! Abnormal renal cortex morphology +is_a: HP:0012575 ! Abnormal nephron morphology +property_value: http://purl.org/dc/elements/1.1/date 2017-08-12T18:30:25Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0031797 +name: Clinical course +namespace: human_phenotype +def: "The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual." [] +synonym: "Natural history of disease" RELATED [] +is_a: HP:0012823 ! Clinical modifier +property_value: http://purl.org/dc/elements/1.1/date 2018-02-25T14:55:46Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032016 +name: Abnormal sputum +namespace: human_phenotype +def: "Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin." [] +synonym: "Abnormal sputum morphology" EXACT [] +is_a: HP:0012252 ! Abnormal respiratory system morphology +property_value: http://purl.org/dc/elements/1.1/date 2018-08-25T12:36:36Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032039 +name: Abnormality of the ocular adnexa +namespace: human_phenotype +def: "An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." [] +is_a: HP:0000315 ! Abnormality of the orbital region +property_value: http://purl.org/dc/elements/1.1/date 2018-09-03T00:17:49Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032101 +name: Unusual infection +namespace: human_phenotype +def: "A type of infection that is regarded as a sign of a pathological susceptibility to infection. There are five general subtypes. (i) Opportunistic infection, meaning infection by a pathogen that is not normally able to cause infection in a healthy host (e.g., pneumonia by Pneumocystis jirovecii or CMV); (ii) Unusual location (focus) of an infection (e.g., an aspergillus brain abscess); (iii) a protracted course or lack of adequate response to treatment (e.g., chronic rhinosinusitis); (iv) Unusual severity or intensity of an infection; and (v) unusual recurrence of infections." [PMID:22052638] +is_a: HP:0010978 ! Abnormality of immune system physiology +property_value: http://purl.org/dc/elements/1.1/date 2018-11-04T22:23:03Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032158 +name: Unusual infection by anatomical site +namespace: human_phenotype +def: "An unusual infection classified by the affected body part." [] +is_a: HP:0032101 ! Unusual infection +property_value: http://purl.org/dc/elements/1.1/date 2018-12-09T12:17:59Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032180 +name: Abnormal circulating metabolite concentration +namespace: human_phenotype +def: "An abnormal level of an analyte measured in the blood." [] +is_a: HP:0001939 ! Abnormality of metabolism/homeostasis +property_value: http://purl.org/dc/elements/1.1/date 2019-01-12T13:45:59Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032245 +name: Abnormal metabolism +namespace: human_phenotype +def: "An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products." [] +is_a: HP:0001939 ! Abnormality of metabolism/homeostasis +property_value: http://purl.org/dc/elements/1.1/date 2019-01-27T12:48:52Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0032263 +name: Increased blood pressure +namespace: human_phenotype +def: "Abnormal increase in blood pressure. An individual measurement of increased blood pressure does not necessarily imply hypertension. In practical terms, multiple measurements are recommended to diagnose the presence of hypertension." [PMID:9137951] +synonym: "Increased BP" EXACT abbreviation [] +is_a: HP:0030972 ! Abnormal systemic blood pressure +property_value: http://purl.org/dc/elements/1.1/date 2019-01-27T20:07:59Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0033127 +name: Abnormality of the musculoskeletal system +namespace: human_phenotype +def: "An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body." [] +is_a: HP:0000118 ! Phenotypic abnormality +property_value: http://purl.org/dc/elements/1.1/date 2020-09-05T13:35:03Z xsd:dateTime +created_by: peter + +[Term] +id: HP:0040075 +name: Hypopituitarism +namespace: human_phenotype +xref: MSH:D007018 +xref: SNOMEDCT_US:74728003 +xref: UMLS:C0020635 +is_a: HP:0011747 ! Abnormality of the anterior pituitary +created_by: HPO:skoehler + +[Term] +id: HP:0040126 +name: Abnormal vitamin B12 level +namespace: human_phenotype +def: "A deviation from the normal concentration of cobalamin (vitamin B12) in the blood. Vitamin B12 is one of the eight B vitamins." [HPO:probinson] +synonym: "Abnormal serum cobalamin level" EXACT [] +xref: UMLS:C4021032 +is_a: HP:0004341 ! Abnormality of vitamin B12 metabolism +created_by: HPO:skoehler + +[Term] +id: HP:0100022 +name: Abnormality of movement +namespace: human_phenotype +alt_id: HP:0001294 +def: "An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements." [HPO:probinson] +comment: Movement disorders are characterized by the phenotypic abnormalities including abnormal involuntary movements, akathisia, akinesia, athetosis, ataxia, ballismus, bradykinesia, chorea, dyskinesia, dystonia, and myoclonus tics, tremor, spasms, and stereotypy. +synonym: "Abnormality of movement" EXACT layperson [] +synonym: "Movement disorder" EXACT layperson [] +synonym: "Unusual movement" EXACT layperson [] +xref: MSH:D009069 +xref: SNOMEDCT_US:60342002 +xref: UMLS:C0026650 +is_a: HP:0012638 ! Abnormal nervous system physiology +created_by: doelkens +creation_date: 2010-05-28T11:48:50Z + +[Term] +id: HP:0100314 +name: Cerebral inclusion bodies +namespace: human_phenotype +def: "Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain." [HPO:probinson] +comment: Inclusion bodies are usually derived from proteins. +xref: UMLS:C4022149 +is_a: HP:0002060 ! Abnormal cerebral morphology +created_by: doelkens +creation_date: 2010-08-10T03:31:18Z + +[Term] +id: HP:0100502 +name: Vitamin B12 deficiency +namespace: human_phenotype +synonym: "Vitamin B12 deficiency" EXACT layperson [] +xref: MSH:D014806 +xref: SNOMEDCT_US:190634004 +xref: UMLS:C0042847 +is_a: HP:0040126 ! Abnormal vitamin B12 level +created_by: doelkens +creation_date: 2010-12-17T06:00:43Z + +[Term] +id: HP:0100508 +name: Abnormality of vitamin metabolism +namespace: human_phenotype +def: "An anomaly in the metabolism of a vitamin." [HPO:probinson] +comment: Vitamins are organic substances that are essential in minute quantities and not produced within the body, instead being present in natural foodstuffs. Vitamins act as coenzymes or precursors of coenzymes in the regulation of metabolic processes. +synonym: "Abnormality of vitamin metabolism" EXACT layperson [] +xref: UMLS:C4022036 +is_a: HP:0032245 ! Abnormal metabolism +created_by: doelkens +creation_date: 2010-12-17T06:17:22Z + +[Term] +id: HP:0100543 +name: Cognitive impairment +namespace: human_phenotype +alt_id: HP:0002128 +alt_id: HP:0002129 +alt_id: HP:0002302 +alt_id: HP:0002337 +alt_id: HP:0002441 +alt_id: HP:0006972 +alt_id: HP:0006998 +alt_id: HP:0007211 +def: "Abnormal cognition with deficits in thinking, reasoning, or remembering." [HPO:sdoelken] +comment: An individual with cognitive impairment may have trouble remembering, learning new things, concentrating, or making decisions. +synonym: "Abnormality of cognition" EXACT layperson [] +synonym: "Cognitive abnormality" EXACT layperson [] +synonym: "Cognitive defects" EXACT layperson [] +synonym: "Cognitive deficits" EXACT layperson [] +synonym: "Cognitive impairment" EXACT layperson [] +synonym: "Intellectual impairment" EXACT layperson [] +xref: MSH:D060825 +xref: SNOMEDCT_US:386806002 +xref: UMLS:C0338656 +xref: UMLS:C0683322 +is_a: HP:0011446 ! Abnormality of higher mental function +created_by: doelkens +creation_date: 2010-12-20T06:50:32Z + +[Term] +id: HP:0100547 +name: Abnormality of forebrain morphology +namespace: human_phenotype +def: "An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle." [HPO:probinson] +synonym: "Abnormal shape of forebrain" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of the forebrain" EXACT [] +xref: UMLS:C4020967 +is_a: HP:0012443 ! Abnormality of brain morphology +created_by: doelkens +creation_date: 2010-12-21T02:12:53Z + +[Term] +id: HP:0100659 +name: Abnormal cerebral vascular morphology +namespace: human_phenotype +def: "An anomaly of the cerebral blood vessels." [PMID:30335330] +synonym: "Abnormality of the cerebral blood vessels" EXACT layperson [ORCID:0000-0001-5208-3432] +synonym: "Abnormality of the cerebral vasculature" EXACT [] +xref: UMLS:C4022001 +is_a: HP:0002597 ! Abnormality of the vasculature +is_a: HP:0012443 ! Abnormality of brain morphology +created_by: doelkens +creation_date: 2010-12-30T11:39:15Z + +[Term] +id: HP:0100763 +name: Abnormality of the lymphatic system +namespace: human_phenotype +alt_id: HP:0003012 +def: "An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively." [HPO:probinson] +synonym: "Lymphatic disease" RELATED [] +xref: MSH:D008206 +xref: SNOMEDCT_US:111590001 +xref: SNOMEDCT_US:234087005 +xref: SNOMEDCT_US:3305006 +xref: SNOMEDCT_US:362971004 +xref: UMLS:C0024228 +xref: UMLS:C4021976 +is_a: HP:0002597 ! Abnormality of the vasculature +is_a: HP:0002715 ! Abnormality of the immune system +created_by: doelkens +creation_date: 2011-06-07T10:40:36Z + +[Term] +id: HP:0100765 +name: Abnormality of the tonsils +namespace: human_phenotype +def: "An abnormality of the tonsils." [HPO:probinson] +xref: UMLS:C4021975 +is_a: HP:0100763 ! Abnormality of the lymphatic system +created_by: doelkens +creation_date: 2011-06-07T10:43:35Z + +[Term] +id: HP:0100886 +name: Abnormality of globe location +namespace: human_phenotype +def: "An abnormality in the placement of the ocular globe (eyeball)." [HPO:sdoelken] +synonym: "Abnormality of eyeball location" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of eyeball position" EXACT layperson [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of globe position" EXACT [ORCID:0000-0001-5889-4463] +xref: UMLS:C4021946 +is_a: HP:0012372 ! Abnormal eye morphology +created_by: doelkens +creation_date: 2011-12-13T04:25:29Z + +[Term] +id: HP:0200036 +name: Skin nodule +namespace: human_phenotype +def: "Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat." [HPO:skoehler] +comment: A nodule is a palpable, solid, round lesion in the deep skin or subcuteaneous tissues that is larger and deeper than a papule. Nodules are solid circumscribed masses. A common definition is that a skin nodule has a diameter of more than 5 mm in infants and more than 10 mm in older children. +synonym: "Growth of abnormal tissue on or under the skin" EXACT [] +xref: SNOMEDCT_US:95319004 +xref: UMLS:C0037287 +is_a: HP:0011355 ! Localized skin lesion +created_by: sebastiankohler +creation_date: 2010-06-18T01:48:50Z + +[Term] +id: HP:0410008 +name: Abnormality of the peripheral nervous system +namespace: human_phenotype +def: "Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord." [ORCID:0000-0001-5889-4463] +synonym: "Abnormality of the peripheral nervous system" EXACT layperson [] +xref: UMLS:C4073187 +is_a: HP:0000707 ! Abnormality of the nervous system + +[Term] +id: HP:0410280 +name: Pediatric onset +namespace: human_phenotype +def: "Onset of disease manifestations before adulthood, defined here as before the age of 15 years, but excluding neonatal or congenital onset." [ORCID:0000-0002-0843-4271] +synonym: "Onset before adulthood" EXACT [] +synonym: "Paediatric onset" EXACT uk_spelling [] +is_a: HP:0003674 ! Onset +property_value: http://purl.org/dc/elements/1.1/date 2018-11-01T15:27:45Z xsd:dateTime +created_by: http://orcid.org/0000-0001-5208-3432 + +[Term] +id: IAO:0000005 +name: objective specification +def: "A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved." [] +def: "a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved." [] +is_a: IAO:0000033 ! directive information entity + +[Term] +id: IAO:0000007 +name: action specification +def: "a directive information entity that describes an action the bearer will take" [] +def: "A directive information entity that describes an action the bearer will take." [] +is_a: IAO:0000033 ! directive information entity + +[Term] +id: IAO:0000015 +name: information carrier +def: "A quality of an information bearer that imparts the information content" [] +is_a: BFO:0000019 ! quality +intersection_of: BFO:0000019 ! quality +intersection_of: RO:0000059 IAO:0000030 ! concretizes information content entity +relationship: RO:0000059 IAO:0000030 ! concretizes information content entity + +[Term] +id: IAO:0000027 +name: data item +def: "a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." [] +def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." [] +is_a: IAO:0000030 ! information content entity +property_value: IAO:0000111 "data item" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl + +[Term] +id: IAO:0000030 +name: information content entity +def: "A generically dependent continuant that is about some thing." [] +is_a: BFO:0000031 ! generically dependent continuant +relationship: IAO:0000136 BFO:0000001 ! is about entity +property_value: IAO:0000111 "information content entity" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/iao.owl + +[Term] +id: IAO:0000033 +name: directive information entity +def: "An information content entity whose concretizations indicate to their bearer how to realize them in a process." [] +is_a: IAO:0000030 ! information content entity +relationship: IAO:0000136 BFO:0000017 ! is about realizable entity + +[Term] +id: IAO:0000078 +name: curation status specification +def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] +is_a: IAO:0000102 ! data about an ontology part +property_value: editor_note "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string +property_value: IAO:0000111 "curation status specification" xsd:string +property_value: IAO:0000114 IAO:0000125 +property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string +property_value: IAO:0000119 GROUP:OBI: xsd:string +property_value: IAO:0000119 "OBI_0000266" xsd:string + +[Term] +id: IAO:0000102 +name: data about an ontology part +def: "Data about an ontology part is a data item about a part of an ontology, for example a term" [] +def: "data about an ontology part is a data item about a part of an ontology, for example a term" [] +is_a: IAO:0000027 ! data item +property_value: IAO:0000111 "data about an ontology part" xsd:string +property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string + +[Term] +id: IAO:0000104 +name: plan specification +def: "A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified." [] +is_a: IAO:0000033 ! directive information entity +relationship: has_part IAO:0000005 ! objective specification +relationship: has_part IAO:0000007 ! action specification + +[Term] +id: IAO:0000178 +name: material information bearer +def: "A material entity in which a concretization of an information content entity inheres." [] +is_a: BFO:0000040 ! material entity + +[Term] +id: IAO:0000225 +name: obsolescence reason specification +def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] +is_a: IAO:0000102 ! data about an ontology part +property_value: editor_note "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string +property_value: IAO:0000111 "obsolescence reason specification" xsd:string +property_value: IAO:0000114 IAO:0000125 +property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string + +[Term] +id: IAO:0000409 +name: denotator type +def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] +is_a: IAO:0000102 ! data about an ontology part +property_value: IAO:0000111 "denotator type" xsd:string +property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string +property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string +property_value: IAO:0000117 "Alan Ruttenberg" xsd:string +property_value: IAO:0000117 "Alan Ruttenberg" xsd:string +property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string +property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string + +[Term] +id: MF:0000008 +name: cognitive process +def: "A mental process that creates, modifies or has as participant some cognitive representation." [] +is_a: MF:0000020 ! mental process +relationship: BFO:0000167 MF:0000031 ! has participant at all times cognitive representation +property_value: seeAlso "GO:0050890, cognition, defined as `The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.' " xsd:string + +[Term] +id: MF:0000017 +name: consciousness +def: "Consciousness is an inseparable part of all mental processes. It is that part of the mental process that:\na) confers a subjective perspective, a phenomenology, an experience of the mental process of which it is a part; and\nb) intends the object or event that the mental process is about, should such exist; i.e., it confers intentionality on the mental process." [] +comment: Note that while there are different modes of consciousness corresponding to the different senses, the whole of conscious experience at any one time is largely experienced as a unity, that is, as a fused whole. Mental processes which are simultaneously ongoing are separable only in fiat, not in essence. +is_a: BFO:0000144 ! process profile +relationship: BFO:0000055 MF:0000076 ! realizes intentional modality +relationship: BFO:0000167 MF:0000073 ! has participant at all times intentionality + +[Term] +id: MF:0000020 +name: mental process +def: "A mental process is a bodily process that is of a type such that it can of itself be conscious. Examples include thinking, feeling pain, remembering and emotion as occurrent experiences. " [] +comment: A bodily process which brings into being, sustains or modifies a cognitive representation or a beahvior inducing state. +is_a: OGMS:0000060 ! bodily process +relationship: BFO:0000055 MF:0000033 ! realizes mental disposition +relationship: BFO:0000117 MF:0000017 ! has occurrent part consciousness +property_value: seeAlso "GO:0050890, cognition, defined as `The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.' " xsd:string + +[Term] +id: MF:0000030 +name: representation +def: "A dependent continuant which is about a portion of reality." [] +is_a: BFO:0000020 ! specifically dependent continuant +property_value: IAO:0000119 http://www.jbiomedsem.com/content/1/1/10 xsd:string + +[Term] +id: MF:0000031 +name: cognitive representation +def: "A representation which specifically depends on an anatomical structure in the cognitive system of an organism." [] +is_a: MF:0000030 ! representation +property_value: IAO:0000119 http://www.jbiomedsem.com/content/1/1/10 xsd:string + +[Term] +id: MF:0000032 +name: bodily disposition +def: "A bodily disposition is a disposition that inheres in some extended organism. Examples are: my disposition to catch a cold when exposed to a virus, my ability to speak the English language." [] +is_a: BFO:0000016 ! disposition +relationship: BFO:0000052 OGMS:0000087 ! inheres in at all times extended organism + +[Term] +id: MF:0000033 +name: mental disposition +def: "A mental disposition is a bodily disposition that is realized in a mental process. " [] +is_a: MF:0000032 ! bodily disposition + +[Term] +id: MF:0000073 +name: intentionality +def: "Intentionality is the fundamental quality of conscious mental processes of always having content, of being directed towards, or about something." [] +is_a: MF:0000075 ! mental quality + +[Term] +id: MF:0000074 +name: bodily quality +def: "A bodily quality is a quality that inheres in some extended organism." [] +is_a: BFO:0000019 ! quality + +[Term] +id: MF:0000075 +name: mental quality +def: "A mental quality is a bodily quality that inheres in those structures of the extended organism that are essential for mental functioning." [] +is_a: MF:0000074 ! bodily quality + +[Term] +id: MF:0000076 +name: intentional modality +def: "A structural capacity that shapes how an object of intentionality is represented for the subject." [] +is_a: MF:0000033 ! mental disposition +property_value: IAO:0000112 "An example of an intentional modality is the capacity to represent objects of intentionality as unfolding in time or being time contingent." xsd:string +property_value: IAO:0000118 "intentional mode" xsd:string +property_value: IAO:0000118 "intentional structure" xsd:string + +[Term] +id: MONDO:0000001 +name: disease or disorder +def: "A disease is a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism." [OGMS:0000031] +synonym: "condition" EXACT [NCIT:C2991] +synonym: "disease" EXACT [NCIT:C2991] +synonym: "disease or disorder" EXACT [NCIT:C2991] +synonym: "disease or disorder, non-neoplastic" EXACT [NCIT:C2991] +synonym: "diseases" EXACT [NCIT:C2991] +synonym: "diseases and disorders" EXACT [NCIT:C2991] +synonym: "disorder" EXACT [NCIT:C2991] +synonym: "disorders" EXACT [NCIT:C2991] +synonym: "medical condition" EXACT [] +synonym: "other disease" EXACT [NCIT:C2991] +xref: DOID:4 {source="MONDO:equivalentTo", source="EFO:0000408"} +xref: EFO:0000408 {source="MONDO:equivalentTo"} +xref: ICD9:799.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D004194 {source="MONDO:equivalentTo", source="DOID:4", source="EFO:0000408"} +xref: NCIT:C2991 {source="MONDO:equivalentTo", source="DOID:4"} +xref: OGMS:0000031 {source="MONDO:equivalentTo"} +xref: Orphanet:377788 {source="MONDO:equivalentTo"} +xref: SCTID:64572001 {source="MONDO:equivalentTo", source="DOID:4", source="EFO:0000408"} +xref: UMLS:C0012634 {source="MONDO:equivalentTo", source="NCIT:C2991", source="DOID:4"} +is_a: BFO:0000016 ! disposition +property_value: exactMatch DOID:4 +property_value: exactMatch http://identifiers.org/mesh/D004194 +property_value: exactMatch http://identifiers.org/snomedct/64572001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0012634 +property_value: exactMatch NCIT:C2991 +property_value: exactMatch Orphanet:377788 + +[Term] +id: MONDO:0000065 +name: microvascular complications of diabetes, susceptibility +comment: Editor note: relationship to diabetic angiopathy +subset: predisposition +synonym: "microvascular complications of diabetes" EXACT [OMIMPS:603933] +xref: OMIMPS:603933 {source="MONDO:equivalentTo"} +xref: UMLS:CN357508 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005266 ! diabetic retinopathy +relationship: predisposes_towards MONDO:0005266 ! diabetic retinopathy +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN357508 +property_value: exactMatch https://omim.org/phenotypicSeries/PS603933 +property_value: http://purl.org/dc/terms/conformsTo inherited:susceptibility.yaml +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0000162 +name: autoimmune thyroid disease, susceptibility to +subset: predisposition +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005623 ! autoimmune thyroid disease +relationship: predisposes_towards MONDO:0005623 ! autoimmune thyroid disease +property_value: excluded_subClassOf MONDO:0007699 +property_value: http://purl.org/dc/terms/conformsTo inherited:susceptibility.yaml + +[Term] +id: MONDO:0000167 +name: Huntington disease and related disorders +def: "A grouping for Huntington disease and similar diseases." [MONDO:cjm] +is_a: MONDO:0024237 ! inherited neurodegenerative disorder + +[Term] +id: MONDO:0000210 +name: thiopurine metabolic disease +xref: OMIMPS:610460 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 ! inborn errors of metabolism +property_value: exactMatch https://omim.org/phenotypicSeries/PS610460 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0000224 +name: acquired carbohydrate metabolism disease +def: "An acquired metabolic disease that is has its basis in the disruption of carbohydrate metabolism." [https://orcid.org/0000-0002-6601-2165] +synonym: "carbohydrate metabolism disease" RELATED [DOID:0050013] +xref: DOID:0050013 {source="MONDO:equivalentTo"} +is_a: MONDO:0006504 ! acquired metabolic disease +is_a: MONDO:0037792 ! carbohydrate metabolism disease +intersection_of: MONDO:0006504 ! acquired metabolic disease +intersection_of: disease_has_basis_in_disruption_of GO:0005975 ! carbohydrate metabolic process +property_value: exactMatch DOID:0050013 + +[Term] +id: MONDO:0000226 +name: mineral metabolism disease +synonym: "disease of mineral metabolism" EXACT [] +synonym: "disorder of mineral metabolism" EXACT [] +xref: ICD10CM:E83 {source="MONDO:equivalentTo"} +xref: ICD9:275.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:275.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:45744005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="ICD10CM:E83", source="MONDO:cjm"} ! metabolic disease +property_value: exactMatch http://identifiers.org/snomedct/45744005 +property_value: exactMatch https://icd.codes/icd10cm/E83 + +[Term] +id: MONDO:0000252 +name: inflammatory diarrhea +def: "An diarrhea (disease) involving a pathogenic inflammatory response in the intestinal mucosa." [MONDO:patterns/specific_inflammatory_disease_by_site] +xref: DOID:0050132 {source="MONDO:equivalentTo"} +xref: SCTID:95544006 {source="MONDO:equivalentTo"} +is_a: MONDO:0000888 ! gastrointestinal mucositis +is_a: MONDO:0001673 ! diarrheal disease +is_a: MONDO:0002269 ! gastroenteritis +intersection_of: MONDO:0001673 ! diarrheal disease +intersection_of: disease_has_inflammation_site UBERON:0001242 ! intestinal mucosa +relationship: disease_has_inflammation_site UBERON:0001242 ! intestinal mucosa +property_value: exactMatch DOID:0050132 +property_value: exactMatch http://identifiers.org/snomedct/95544006 + +[Term] +id: MONDO:0000257 +name: acute diarrhea +def: "Acute form of diarrhea." [MONDO:patterns/acute] +synonym: "acute diarrheal disease" EXACT [MONDO:design_pattern] +synonym: "diarrhea (disease), acute" EXACT [MONDO:patterns/acute] +synonym: "diarrhea, acute" EXACT [MONDO:patterns/acute] +synonym: "diarrheal disease, acute" EXACT [MONDO:design_pattern, MONDO:patterns/acute] +xref: DOID:0050140 {source="MONDO:equivalentTo"} +xref: SCTID:409966000 {source="MONDO:equivalentTo"} +xref: UMLS:C0740441 {source="MONDO:equivalentTo"} +is_a: MONDO:0001673 {source="DOID:0050140", source="MONDO:Redundant"} ! diarrheal disease +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0001673 ! diarrheal disease +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:0050140 +property_value: exactMatch http://identifiers.org/snomedct/409966000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0740441 + +[Term] +id: MONDO:0000261 +name: adenoiditis +def: "An inflammatory disease involving a pathogenic inflammatory response in the pharyngeal tonsil." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "chronic adenoiditis" NARROW [DOID:0050145] +synonym: "inflammation of pharyngeal tonsil" EXACT [] +synonym: "pharyngeal tonsil inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "pharyngeal tonsilitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:0050145 {source="MONDO:equivalentTo"} +xref: ICD10CM:J35.02 {source="DOID:0050145", source="MONDO:equivalentTo"} +xref: ICD9:474.01 {source="DOID:0050145"} +xref: SCTID:70020005 {source="MONDO:equivalentTo"} +xref: UMLS:C0001427 {source="MONDO:equivalentTo"} +xref: UMLS:C0396023 {source="DOID:0050145", source="MONDO:equivalentTo"} +is_a: MONDO:0001039 ! tonsillitis +is_a: MONDO:0001040 ! nasopharyngitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001732 ! pharyngeal tonsil +relationship: disease_has_inflammation_site UBERON:0001732 ! pharyngeal tonsil +property_value: exactMatch DOID:0050145 +property_value: exactMatch http://identifiers.org/snomedct/70020005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001427 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0396023 +property_value: exactMatch https://icd.codes/icd10cm/J35.02 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000263 +name: laryngotracheitis +def: "An inflammation of both larynx and trachea." [MONDO:patterns] +xref: DOID:0050148 {source="MONDO:equivalentTo"} +xref: ICD9:464 {source="DOID:0050148"} +xref: ICD9:464.2 {source="DOID:0050148"} +xref: ICD9:476.1 {source="DOID:0050148"} +xref: SCTID:55130001 {source="UMLS:C0023076", source="MONDO:equivalentTo"} +xref: UMLS:C0023076 {source="MONDO:equivalentTo"} +is_a: MONDO:0002647 ! laryngitis +is_a: MONDO:0005990 ! tracheitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001737 ! larynx +intersection_of: disease_has_inflammation_site UBERON:0003126 ! trachea +property_value: exactMatch DOID:0050148 +property_value: exactMatch http://identifiers.org/snomedct/55130001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023076 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0000270 +name: lower respiratory tract disorder +def: "A disease involving the lower respiratory tract." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of lower respiratory tract" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lower respiratory tract" EXACT [] +synonym: "disorder of lower respiratory tract" EXACT [MONDO:patterns/location_top] +synonym: "lower respiratory tract disease" EXACT [MONDO:patterns/location] +synonym: "lower respiratory tract disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0050161 {source="MONDO:equivalentTo"} +xref: ICD9:478.1 {source="DOID:0050161"} +xref: ICD9:478.19 {source="DOID:0050161"} +xref: SCTID:128272009 {source="MONDO:equivalentTo"} +xref: UMLS:C1290325 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 {source="DOID:0050161", source="MONDO:Redundant"} ! respiratory system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001558 ! lower respiratory tract +relationship: disease_has_location UBERON:0001558 ! lower respiratory tract +property_value: exactMatch DOID:0050161 +property_value: exactMatch http://identifiers.org/snomedct/128272009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290325 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000314 +name: primary bacterial infectious disease +xref: DOID:0050338 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 {source="DOID:0050338", source="MONDO:Redundant"} ! bacterial infectious disease +intersection_of: MONDO:0005113 ! bacterial infectious disease +intersection_of: has_modifier MONDO:0045036 ! primary infectious +relationship: has_modifier MONDO:0045036 ! primary infectious +property_value: exactMatch DOID:0050338 +property_value: http://purl.org/dc/terms/conformsTo primary:infectious.yaml + +[Term] +id: MONDO:0000327 +name: Buruli ulcer disease +def: "A cutaneous infection caused by Mycobacterium ulcerans. It presents with painless nodular swelling of the skin, leading to the formation of necrotizing ulcers." [NCIT:P378] +synonym: "Bairnsdale ulcer" EXACT [DOID:0050456] +synonym: "Buruli ulcer" EXACT [NCIT:C84604] +synonym: "Daintree ulcer" EXACT [DOID:0050456] +synonym: "Mossman ulcer" EXACT [DOID:0050456] +synonym: "Mycobacterium ulcerans caused disease or disorder" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Mycobacterium ulcerans disease or disorder" EXACT [] +synonym: "Mycobacterium ulcerans infectious disease" EXACT [] +synonym: "Searl ulcer" EXACT [DOID:0050456] +synonym: "Searle's ulcer" EXACT [DOID:0050456] +xref: DOID:0050456 {source="MONDO:equivalentTo"} +xref: EFO:1001281 {source="MONDO:equivalentTo"} +xref: MESH:D054312 {source="DOID:0050456", source="MONDO:equivalentTo"} +xref: NCIT:C84604 {source="DOID:0050456", source="MONDO:equivalentTo"} +xref: SCTID:15845006 {source="DOID:0050456", source="MONDO:equivalentTo"} +xref: UMLS:C0085568 {source="DOID:0050456", source="NCIT:C84604", source="MONDO:equivalentTo"} +is_a: MONDO:0000314 {source="DOID:0050456"} ! primary bacterial infectious disease +is_a: MONDO:0020590 ! mycobacterial infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:1809 ! Mycobacterium ulcerans +relationship: disease_has_infectious_agent NCBITaxon:1809 ! Mycobacterium ulcerans +property_value: exactMatch DOID:0050456 +property_value: exactMatch http://identifiers.org/mesh/D054312 +property_value: exactMatch http://identifiers.org/snomedct/15845006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085568 +property_value: exactMatch NCIT:C84604 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/infectious_disease_by_agent.yaml + +[Term] +id: MONDO:0000376 +name: respiratory system cancer +def: "A malignant neoplasm involving the respiratory system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of respiratory system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of respiratory system" EXACT [MONDO:patterns/cancer] +synonym: "malignant respiratory system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "respiratory system cancer" EXACT [MONDO:patterns/location] +xref: DOID:0050615 {source="MONDO:equivalentTo"} +xref: ICD9:165.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:165.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:449096009 {source="MONDO:equivalentTo"} +xref: UMLS:C3164456 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:0050615", source="DOID:0050615/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0005087 {source="DOID:0050615", source="MONDO:Redundant"} ! respiratory system disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001004 ! respiratory system +property_value: exactMatch DOID:0050615 +property_value: exactMatch http://identifiers.org/snomedct/449096009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3164456 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000380 +name: paranasal sinus carcinoma +def: "A malignant epithelial neoplasm arising in the paranasal sinus." [NCIT:C6014] +synonym: "accessory sinus cancer" EXACT [NCIT:C6014] +synonym: "accessory sinus carcinoma" EXACT [NCIT:C6014] +synonym: "adenoid cystic carcinoma of accessory sinus" RELATED [DOID:0050619] +synonym: "adenoid cystic carcinoma of paranasal sinus" RELATED [DOID:0050619] +synonym: "cancer of paranasal sinus" EXACT [MONDO:patterns/cancer] +synonym: "carcinoma of accessory sinus" EXACT [NCIT:C6014] +synonym: "carcinoma of paranasal sinus" EXACT [MONDO:patterns/carcinoma, NCIT:C6014] +synonym: "carcinoma of the accessory sinus" EXACT [NCIT:C6014] +synonym: "carcinoma of the paranasal sinus" EXACT [NCIT:C6014] +synonym: "epidermoid carcinoma of the paranasal sinus" RELATED [DOID:0050619] +synonym: "malignant neoplasm of paranasal sinus" BROAD [MONDO:patterns/cancer] +synonym: "malignant paranasal sinus neoplasm" BROAD [MONDO:patterns/cancer] +synonym: "mucoepidermoid carcinoma of accessory sinus" RELATED [DOID:0050619] +synonym: "paranasal sinus adenocarcinoma" RELATED [DOID:0050619] +synonym: "paranasal sinus adenoid cystic carcinoma" RELATED [DOID:0050619] +synonym: "paranasal sinus cancer" BROAD [MONDO:patterns/location, NCIT:C6014] +synonym: "paranasal sinus carcinoma" EXACT [NCIT:C6014] +synonym: "paranasal sinus mucoepidermoid carcinoma" RELATED [DOID:0050619] +synonym: "paranasal sinus squamous cell carcinoma" RELATED [DOID:0050619] +synonym: "squamous cell carcinoma of paranasal sinus" RELATED [DOID:0050619] +xref: DOID:0050619 {source="MONDO:equivalentTo"} +xref: NCIT:C6014 {source="MONDO:equivalentTo", source="DOID:0050619"} +xref: UMLS:C0854995 {source="MONDO:equivalentTo", source="DOID:0050619"} +is_a: MONDO:0002415 ! bone carcinoma +is_a: MONDO:0020669 ! paranasal sinus cancer +is_a: MONDO:0056819 {source="NCIT:C6014"} ! nasal cavity and paranasal sinus carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch DOID:0050619 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854995 +property_value: exactMatch NCIT:C6014 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0000381 +name: infiltrating renal pelvis transitional cell carcinoma +def: "A infiltrating urothelial carcinoma that involves the renal pelvis." [MONDO:patterns/location] +xref: DOID:0050620 {source="MONDO:equivalentTo"} +is_a: MONDO:0004010 ! infiltrating renal pelvis/ureter urothelial carcinoma +is_a: MONDO:0005221 {source="DOID:0050620", source="MONDO:Redundant"} ! renal pelvis urothelial carcinoma +intersection_of: MONDO:0040678 ! infiltrating urothelial carcinoma +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:0050620 + +[Term] +id: MONDO:0000382 +name: respiratory system benign neoplasm +def: "A benign neoplasm that involves the respiratory system." [MONDO:patterns/location] +synonym: "respiratory system benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0050621 {source="MONDO:equivalentTo"} +xref: SCTID:255166003 {source="MONDO:equivalentTo"} +xref: UMLS:C0497556 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 {source="DOID:0050621", source="MONDO:Redundant"} ! respiratory system disorder +is_a: MONDO:0005165 {source="DOID:0050621", source="DOID:0050621/inferred", source="MONDO:Redundant"} ! benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001004 ! respiratory system +property_value: exactMatch DOID:0050621 +property_value: exactMatch http://identifiers.org/snomedct/255166003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0497556 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000383 +name: benign reproductive system neoplasm +def: "A non-metastasizing neoplasm that arises from the male or female reproductive system. Representative examples include benign prostate phyllodes tumor, benign Sertoli cell tumor, uterine corpus leiomyoma, and benign ovarian serous tumor." [NCIT:C7617] +synonym: "benign reproductive system neoplasm" EXACT [NCIT:C7617] +synonym: "reproductive organ benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0050622 {source="MONDO:equivalentTo"} +xref: NCIT:C7617 {source="MONDO:equivalentTo"} +xref: UMLS:C1332536 {source="MONDO:equivalentTo", source="NCIT:C7617"} +is_a: MONDO:0005165 {source="DOID:0050622", source="DOID:0050622/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0006054 {source="MONDO:Redundant", source="NCIT:C7617"} ! reproductive system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000990 ! reproductive system +property_value: exactMatch DOID:0050622 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332536 +property_value: exactMatch NCIT:C7617 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000384 +name: bladder benign neoplasm +def: "A benign abnormal growth of the cells that comprise the bladder." [NCIT:P378] +synonym: "benign bladder neoplasm" EXACT [NCIT:C3618] +synonym: "benign bladder tumor" EXACT [NCIT:C3618] +synonym: "benign neoplasm of bladder" EXACT [NCIT:C3618] +synonym: "benign neoplasm of the bladder" EXACT [NCIT:C3618] +synonym: "benign neoplasm of the urinary bladder" EXACT [NCIT:C3618] +synonym: "benign neoplasm of urinary bladder" EXACT [NCIT:C3618] +synonym: "benign tumor of bladder" EXACT [NCIT:C3618] +synonym: "benign tumor of the bladder" EXACT [NCIT:C3618] +synonym: "benign tumor of the urinary bladder" EXACT [NCIT:C3618] +synonym: "benign tumor of urinary bladder" EXACT [NCIT:C3618] +synonym: "benign urinary bladder neoplasm" EXACT [NCIT:C3618] +synonym: "benign urinary bladder tumor" EXACT [NCIT:C3618] +synonym: "urinary bladder benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0050623 {source="MONDO:equivalentTo"} +xref: ICD9:223.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3618 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:91992005 {source="MONDO:equivalentTo"} +xref: UMLS:C0154017 {source="NCIT:C3618", source="MONDO:equivalentTo"} +is_a: MONDO:0004180 {source="DOID:0050623", source="MONDO:Redundant", source="NCIT:C3618"} ! benign urinary system neoplasm +is_a: MONDO:0004987 {source="MONDO:Redundant", source="NCIT:C3618"} ! urinary bladder neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:0050623 +property_value: exactMatch http://identifiers.org/snomedct/91992005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154017 +property_value: exactMatch NCIT:C3618 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000385 +name: benign digestive system neoplasm +def: "A non-metastasizing neoplasm arising from any part of the digestive system." [NCIT:P378] +synonym: "alimentary part of gastrointestinal system benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "benign digestive system tumor" EXACT [NCIT:C4787] +synonym: "benign gastrointestinal neoplasm" EXACT [NCIT:C4787] +synonym: "benign gastrointestinal system tumor" EXACT [NCIT:C4787] +synonym: "benign gastrointestinal tumor" EXACT [NCIT:C4787] +synonym: "benign GI neoplasm" EXACT [NCIT:C4787] +synonym: "benign GI system neoplasm" EXACT [NCIT:C4787] +synonym: "benign GI system tumor" EXACT [NCIT:C4787] +synonym: "benign GI tumor" EXACT [NCIT:C4787] +synonym: "benign neoplasm of digestive system" EXACT [NCIT:C4787] +synonym: "benign neoplasm of gastrointestinal system" EXACT [NCIT:C4787] +synonym: "benign neoplasm of the digestive system" EXACT [NCIT:C4787] +synonym: "benign tumor of digestive system" EXACT [NCIT:C4787] +synonym: "benign tumor of gastrointestinal system" EXACT [NCIT:C4787] +synonym: "benign tumor of GI system" EXACT [NCIT:C4787] +synonym: "benign tumor of the digestive system" EXACT [NCIT:C4787] +synonym: "benign tumor of the gastrointestinal system" EXACT [NCIT:C4787] +synonym: "benign tumor of the GI system" EXACT [NCIT:C4787] +synonym: "gastrointestinal system benign neoplasm" RELATED [DOID:0050624] +xref: DOID:0050624 {source="MONDO:equivalentTo"} +xref: NCIT:C4787 {source="MONDO:equivalentTo"} +xref: UMLS:C0497538 {source="MONDO:equivalentTo", source="NCIT:C4787"} +is_a: MONDO:0004335 {source="DOID:0050624", source="MONDO:Entailed", source="NCIT:C4787/inferred"} ! digestive system disorder +is_a: MONDO:0005165 {source="DOID:0050624", source="DOID:0050624/inferred", source="MONDO:Entailed", source="MONDO:Inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0021223 {source="MONDO:Redundant", source="NCIT:C4787"} ! digestive system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +property_value: exactMatch DOID:0050624 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0497538 +property_value: exactMatch NCIT:C4787 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000386 +name: digestive system neuroendocrine tumor, grade 1/2 +def: "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas." [NCIT:P378] +synonym: "alimentary part of gastrointestinal system neuroendocrine tumor" BROAD [MONDO:patterns/location] +synonym: "digestive system NET" BROAD [NCIT:C95404] +synonym: "digestive system neuroendocrine tumor" BROAD [NCIT:C95404] +synonym: "digestive system well differentiated neuroendocrine tumor" BROAD [NCIT:C95404] +synonym: "gastroenteropancreatic NET" BROAD [NCIT:C95404] +synonym: "gastroenteropancreatic neuroendocrine tumor" BROAD [NCIT:C95404] +synonym: "gastrointestinal NET" BROAD [NCIT:C95404] +synonym: "gastrointestinal neuroendocrine tumor" BROAD [NCIT:C95404] +synonym: "gastrointestinal neuroendocrine tumors" BROAD [ONCOTREE:GINET] +synonym: "gastrointestinal system neuroendocrine tumor" BROAD [NCIT:C95404] +synonym: "GINET" RELATED ABBREVIATION [ONCOTREE:GINET] +synonym: "malignant gastrointestinal neuroendocrine tumor" NARROW [DOID:0050626] +xref: DOID:0050626 {source="MONDO:equivalentTo"} +xref: NCIT:C95404 {source="MONDO:equivalentTo"} +xref: ONCOTREE:GINET {source="MONDO:equivalentTo"} +xref: UMLS:C2987127 {source="NCIT:C95404", source="MONDO:equivalentObsolete"} +is_a: MONDO:0024503 ! digestive system neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +relationship: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch DOID:0050626 +property_value: exactMatch NCIT:C95404 + +[Term] +id: MONDO:0000405 +name: anal canal cancer +def: "A malignant neoplasm involving the anal canal" [https://orcid.org/0000-0002-6601-2165] +synonym: "anal canal cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of anal canal" EXACT [MONDO:patterns/cancer] +synonym: "malignant anal canal neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of anal canal" EXACT [MONDO:patterns/cancer] +xref: DOID:0050688 {source="MONDO:equivalentTo"} +xref: ICD9:154.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363352004 {source="MONDO:equivalentTo"} +xref: UMLS:C0153445 {source="MONDO:equivalentTo"} +is_a: MONDO:0005814 ! intestinal cancer +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000159 ! anal canal +relationship: disease_has_location UBERON:0000159 ! anal canal +property_value: exactMatch DOID:0050688 +property_value: exactMatch http://identifiers.org/snomedct/363352004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153445 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000424 +name: inborn vitamin B12 deficiency +def: "Low serum levels of vitamin B12 (cobalamin) due to poor intestinal absorption, decreased dietary intake, or increased physiologic requirement." [NCIT:C131684] +synonym: "cobalamin deficiency" BROAD [DOID:0050731] +synonym: "hypocobalaminemia" BROAD [DOID:0050731] +synonym: "inborn cobalamin metabolic process disorder" EXACT [] +synonym: "inborn error of cobalamin metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn vitamin B12 deficiency (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "rare inborn error of cobalamin metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:0050731 {source="MONDO:equivalentTo"} +xref: EFO:0000734 {source="MONDO:equivalentTo"} +is_a: MONDO:0005528 {source="HP:0100502", source="MONDO:Entailed", source="MONDO:Redundant"} ! inborn vitamin metabolic disorder +is_a: MONDO:0020696 ! vitamin B12 deficiency +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0009235 ! cobalamin metabolic process +property_value: exactMatch DOID:0050731 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: IAO:0000589 "inborn vitamin B12 deficiency (disease)" xsd:string + +[Term] +id: MONDO:0000426 +name: autosomal dominant disease +def: "Autosomal dominant form of disease." [MONDO:patterns/autosomal_dominant] +synonym: "autosomal dominant disease or disorder" EXACT [MONDO:design_pattern] +synonym: "autosomal dominant hereditary disorder" EXACT [] +synonym: "autosomal dominant inherited disorder" EXACT [] +synonym: "disease or disorder, autosomal dominant" EXACT [MONDO:patterns/autosomal_dominant] +synonym: "disease, autosomal dominant" EXACT [MONDO:patterns/autosomal_dominant] +xref: DOID:0050736 {source="MONDO:equivalentTo"} +xref: ICD9:758.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:11164009 {source="MONDO:equivalentTo"} +xref: UMLS:C0265385 {source="MONDO:equivalentTo"} +is_a: MONDO:0000429 {source="DOID:0050736"} ! autosomal genetic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: has_modifier HP:0000006 ! Autosomal dominant inheritance +relationship: has_modifier HP:0000006 ! Autosomal dominant inheritance +property_value: exactMatch DOID:0050736 +property_value: exactMatch http://identifiers.org/snomedct/11164009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0265385 +property_value: http://purl.org/dc/terms/conformsTo autosomal:dominant.yaml + +[Term] +id: MONDO:0000429 +name: autosomal genetic disease +def: "A monogenic disease that is has material basis in a mutation in a single gene on one of the non-sex chromosomes." [DOID:0050739, http://ghr.nlm.nih.gov/glossary=autosomaldominant, http://ghr.nlm.nih.gov/handbook/inheritance/inheritancepatterns] +synonym: "autosomal hereditary disorder" EXACT [] +synonym: "autosomal inherited disease" EXACT [] +synonym: "autosomal inherited disorder" EXACT [] +xref: DOID:0050739 {source="MONDO:equivalentTo"} +xref: ICD9:758.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:1899006 {source="MONDO:equivalentTo"} +xref: UMLS:C0265384 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 {source="https://github.com/monarch-initiative/mondo/issues/1758"} ! Mendelian disease +property_value: exactMatch DOID:0050739 +property_value: exactMatch http://identifiers.org/snomedct/1899006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0265384 + +[Term] +id: MONDO:0000437 +name: cerebellar ataxia +def: "A neurological syndrome characterised by clumsy and unco-ordinated movement of the limbs, trunk, and cranial muscles. It results from pathology in the cerebellum and its connections, or in the proprioceptive sensory pathways." [https://bestpractice.bmj.com/topics/en-gb/1097] +comment: In ORDO this is called rare ataxia, we rename as ataxia since all forms are individually rare +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:102002"} +synonym: "ataxia" EXACT AMBIGUOUS [] +synonym: "ataxia syndrome" EXACT [MONDO:0015142] +synonym: "ataxia, cerebellar" RELATED [MESH:D002524] +synonym: "ataxias, cerebellar" RELATED [MESH:D002524] +synonym: "cerebellar Ataxias" RELATED [MESH:D002524] +synonym: "cerebellar dysmetria" RELATED [MESH:D002524] +synonym: "cerebellar Dysmetrias" RELATED [MESH:D002524] +synonym: "rare ataxia" RELATED [Orphanet:102002] +synonym: "spinocerebellar ataxia" NARROW [] +synonym: "spinocerebellar Degeneration" EXACT [NCIT:C82341] +xref: DOID:0050753 {source="MONDO:equivalentTo"} +xref: GARD:0012060 {source="MONDO:equivalentTo"} +xref: ICD9:334.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D002524 {source="MONDO:equivalentTo"} +xref: NCIT:C82341 {source="MONDO:equivalentTo"} +xref: Orphanet:102002 {source="MONDO:equivalentTo"} +xref: SCTID:85102008 {source="MONDO:equivalentTo"} +xref: UMLS:C0087012 {source="MONDO:equivalentTo"} +is_a: MONDO:0002427 {source="DOID:0050753", source="MESH:D002524"} ! cerebellar disorder +is_a: MONDO:0005395 {source="MESH:D002524/inferred", source="https://bestpractice.bmj.com/topics/en-gb/1097"} ! movement disorder +is_a: MONDO:0100308 {source="https://orcid.org/0000-0002-0736-9199"} ! atactic disorder +intersection_of: MONDO:0100308 ! atactic disorder +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0002037 ! cerebellum +relationship: disease_has_basis_in_dysfunction_of UBERON:0002037 ! cerebellum +relationship: disease_has_feature HP:0001251 ! Ataxia +relationship: has_modifier MONDO:0021136 {source="MONDO:0020009", source="https://bestpractice.bmj.com/topics/en-gb/1097"} ! rare +property_value: exactMatch DOID:0050753 +property_value: exactMatch http://identifiers.org/mesh/D002524 +property_value: exactMatch http://identifiers.org/snomedct/85102008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0087012 +property_value: exactMatch NCIT:C82341 +property_value: exactMatch Orphanet:102002 + +[Term] +id: MONDO:0000448 +name: paraganglioma +def: "A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases." [NCIT:C3308] +synonym: "chemodectoma" NARROW [DOID:0050773] +synonym: "neoplasm of paraganglion" EXACT [NCIT:C3308] +synonym: "neoplasm of the paraganglion" EXACT [NCIT:C3308] +synonym: "paraganglioma" EXACT [NCIT:C3308] +synonym: "paragangliomas" EXACT [OMIMPS:168000] +synonym: "paraganglion neoplasm" EXACT [NCIT:C3308] +synonym: "paraganglion tumor" EXACT [NCIT:C3308] +synonym: "Paraganglionic neoplasm" EXACT [NCIT:C3308] +synonym: "Paraganglionic tumor" EXACT [NCIT:C3308] +synonym: "tumor of paraganglion" EXACT [NCIT:C3308] +synonym: "tumor of the paraganglion" EXACT [NCIT:C3308] +xref: DOID:0050773 {source="MONDO:equivalentTo"} +xref: EFO:1000453 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8680/1 {source="NCIT:C3308"} +xref: MESH:D010235 {source="DOID:0050773", source="MONDO:equivalentTo"} +xref: NCIT:C3308 {source="DOID:0050773", source="MONDO:equivalentTo"} +xref: OMIMPS:168000 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: ONCOTREE:PGNG {source="MONDO:equivalentTo"} +xref: SCTID:127027008 {source="DOID:0050773", source="MONDO:equivalentTo"} +xref: UMLS:C0030421 {source="NCIT:C3308", source="DOID:0050773", source="MONDO:equivalentTo"} +is_a: MONDO:0002366 {source="MONDO:Redundant", source="NCIT:C3308"} ! autonomic nervous system neoplasm +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0021635 {source="Wikipedia:Neurocristopathy"} ! neurocristopathy +is_a: MONDO:0025511 ! inherited neuroendocrine tumor +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_arises_from_structure CL:0011012 ! neural crest cell +intersection_of: disease_has_location UBERON:0002410 ! autonomic nervous system +relationship: disease_arises_from_structure CL:0011012 ! neural crest cell +property_value: exactMatch DOID:0050773 +property_value: exactMatch http://identifiers.org/mesh/D010235 +property_value: exactMatch http://identifiers.org/snomedct/127027008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030421 +property_value: exactMatch https://omim.org/phenotypicSeries/PS168000 +property_value: exactMatch NCIT:C3308 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0000462 +name: eye adnexa disorder +def: "A disease involving the ocular adnexa." [MONDO:patterns/location_top] +synonym: "disease of ocular adnexa" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ocular adnexa" EXACT [] +synonym: "disorder of ocular adnexa" EXACT [MONDO:patterns/location_top] +synonym: "ocular adnexa disease" EXACT [MONDO:patterns/location] +synonym: "ocular adnexa disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0050815 {source="MONDO:equivalentObsolete"} +xref: ICD10WHO:H00-H06 {source="MONDO:equivalentTo"} +xref: SCTID:118941004 {source="MONDO:equivalentTo"} +xref: UMLS:C1290855 {source="MONDO:equivalentTo"} +is_a: MONDO:0002022 {source="DOID:0050815", source="ICD10CM:H00-H06", source="MONDO:Redundant"} ! disorder of orbital region +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0035639 ! ocular adnexa +relationship: disease_has_location UBERON:0035639 ! ocular adnexa +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/H00-H06 +property_value: exactMatch http://identifiers.org/snomedct/118941004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290855 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000469 +name: sinoatrial node disorder +def: "A disease involving the sinoatrial node." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of sinoatrial node" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of sinoatrial node" EXACT [] +synonym: "disorder of sinoatrial node" EXACT [MONDO:patterns/location_top] +synonym: "SA node" RELATED [DOID:0050824] +synonym: "sinoatrial node disease" EXACT [MONDO:patterns/location] +synonym: "sinoatrial node disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "sinuatrial node" RELATED [DOID:0050824] +xref: DOID:0050824 {source="MONDO:equivalentTo"} +is_a: MONDO:0000992 {source="DOID:0050824"} ! heart conduction disease +is_a: MONDO:0005449 ! conduction system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002351 ! sinoatrial node +relationship: disease_has_location UBERON:0002351 ! sinoatrial node +property_value: exactMatch DOID:0050824 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000470 +name: endocardium disorder +def: "A disease involving the endocardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of endocardium" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of endocardium" EXACT [] +synonym: "disorder of endocardium" EXACT [MONDO:patterns/location_top] +synonym: "endocardial disease" EXACT [] +synonym: "endocardiopathy" RELATED [] +synonym: "endocardium disease" EXACT [MONDO:patterns/location] +synonym: "endocardium disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0050825 {source="MONDO:equivalentTo"} +xref: SCTID:123596001 {source="MONDO:equivalentTo"} +xref: UMLS:C0854140 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 {source="DOID:0050825", source="MONDO:Redundant"} ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002165 ! endocardium +relationship: disease_has_location UBERON:0002165 ! endocardium +property_value: exactMatch DOID:0050825 +property_value: exactMatch http://identifiers.org/snomedct/123596001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854140 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000471 +name: tricuspid valve disorder +def: "A disease involving the tricuspid valve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of tricuspid valve" EXACT [DOID:0050826, ICD9CM:397.0, MONDO:patterns/location_top] +synonym: "disease or disorder of tricuspid valve" EXACT [] +synonym: "disorder of tricuspid valve" EXACT [MONDO:patterns/location_top] +synonym: "RH. tricuspid valve disease" NARROW [DOID:0050826] +synonym: "rheumatic disease of tricuspid valve" NARROW [DOID:0050826] +synonym: "rheumatic tricuspid valve disease" NARROW [DOID:0050826] +synonym: "tricuspid disease" EXACT [DOID:0050826] +synonym: "tricuspid valve disease" EXACT [MONDO:patterns/location] +synonym: "tricuspid valve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "tricuspid valve disorder" EXACT [NCIT:C78649] +xref: DOID:0050826 {source="MONDO:equivalentTo"} +xref: ICD9:397.0 {source="DOID:0050826"} +xref: NCIT:C78649 {source="MONDO:equivalentTo"} +xref: SCTID:20721001 {source="MONDO:equivalentTo"} +xref: UMLS:C0264776 {source="MONDO:equivalentTo", source="DOID:0050826"} +xref: UMLS:C0264882 {source="NCIT:C78649", source="MONDO:equivalentTo"} +is_a: MONDO:0002869 {source="DOID:0050826", source="MONDO:Redundant", source="NCIT:C78649"} ! heart valve disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002134 ! tricuspid valve +relationship: disease_has_location UBERON:0002134 ! tricuspid valve +property_value: exactMatch DOID:0050826 +property_value: exactMatch http://identifiers.org/snomedct/20721001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264776 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264882 +property_value: exactMatch NCIT:C78649 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000473 +name: arterial disorder +def: "An impairment of the structure or function of the blood vessels which carry blood away from the heart." [NCIT:C35317] +synonym: "arterial disease" EXACT [NCIT:C35317] +synonym: "arterial disorder" EXACT [NCIT:C35317] +synonym: "arteriopathy" EXACT [NCIT:C35317] +synonym: "artery disease" EXACT [MONDO:patterns/location] +synonym: "artery disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of artery" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of artery" EXACT [] +synonym: "disorder of artery" EXACT [MONDO:patterns/location_top] +xref: DOID:0050828 {source="MONDO:equivalentTo"} +xref: ICD9:447.8 +xref: ICD9:447.9 +xref: NCIT:C35317 {source="MONDO:equivalentTo"} +xref: SCTID:359557001 {source="MONDO:equivalentTo"} +xref: UMLS:C0852949 {source="MONDO:equivalentTo", source="NCIT:C35317"} +is_a: MONDO:0005385 {source="DOID:0050828", source="MONDO:Redundant", source="NCIT:C35317/inferred"} ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001637 ! artery +relationship: disease_has_location UBERON:0001637 ! artery +property_value: exactMatch DOID:0050828 +property_value: exactMatch http://identifiers.org/snomedct/359557001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0852949 +property_value: exactMatch NCIT:C35317 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000474 +name: pericardium disorder +def: "A disease involving the pericardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of pericardium" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pericardium" EXACT [] +synonym: "disorder of pericardium" EXACT [MONDO:patterns/location_top] +synonym: "pericardium disease" EXACT [MONDO:patterns/location] +synonym: "pericardium disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0050829 {source="MONDO:equivalentTo"} +xref: ICD9:423.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:423.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:55855009 {source="MONDO:equivalentTo"} +xref: UMLS:C0265122 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002407 ! pericardium +relationship: disease_has_location UBERON:0002407 ! pericardium +property_value: exactMatch DOID:0050829 +property_value: exactMatch http://identifiers.org/snomedct/55855009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0265122 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000489 +name: diabetic encephalopathy +def: "A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes." [DOID:0050850, http://link.springer.com/chapter/10.1007%2F978-1-59745-311-0_11#page-1, PMID:20798963] +xref: DOID:0050850 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 {source="DOID:0050850", source="MONDO:Redundant"} ! brain disorder +intersection_of: MONDO:0005560 ! brain disorder +intersection_of: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +relationship: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +property_value: exactMatch DOID:0050850 + +[Term] +id: MONDO:0000497 +name: pyometritis +def: "Inflammation of uterine musculature associated with pus in the uterine cavity." [https://medical-dictionary.thefreedictionary.com/pyometritis] +synonym: "inflammation of myometrium" EXACT [] +synonym: "myometrium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "pyometra" EXACT [NCIT:C121207] +xref: DOID:0050862 {source="MONDO:equivalentTo"} +xref: MESH:D055112 {source="MONDO:equivalentTo"} +xref: NCIT:C121207 {source="MONDO:equivalentTo"} +xref: SCTID:88981003 {source="MONDO:equivalentTo"} +xref: UMLS:C0034215 {source="NCIT:C121207", source="MONDO:equivalentTo"} +xref: UMLS:C0686163 {source="MONDO:equivalentTo"} +is_a: MONDO:0002654 {source="DOID:0050862", source="MESH:D055112", source="MONDO:Redundant"} ! uterine disorder +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C121207/inferred"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001296 ! myometrium +relationship: disease_has_inflammation_site UBERON:0001296 ! myometrium +property_value: exactMatch DOID:0050862 +property_value: exactMatch http://identifiers.org/mesh/D055112 +property_value: exactMatch http://identifiers.org/snomedct/88981003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034215 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686163 +property_value: exactMatch NCIT:C121207 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000500 +name: tongue squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the tongue. It usually presents as a painful ulcerated or nodular lesion. The size of the tumor and the status of the lymph nodes are the most important factors that determine prognosis." [NCIT:P378] +synonym: "scc of the tongue" EXACT [NCIT:C4648] +synonym: "scc of tongue" EXACT [NCIT:C4648] +synonym: "squamous cell carcinoma of the tongue" EXACT [NCIT:C4648] +synonym: "squamous cell carcinoma of tongue" EXACT [NCIT:C4648] +synonym: "tongue scc" EXACT [NCIT:C4648] +synonym: "tongue squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050865 {source="MONDO:equivalentTo"} +xref: EFO:1000055 {source="MONDO:equivalentTo"} +xref: NCIT:C4648 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:276952000 {source="MONDO:equivalentTo"} +xref: UMLS:C0349566 {source="MONDO:equivalentTo", source="NCIT:C4648"} +is_a: MONDO:0004631 {source="DOID:0050865", source="MONDO:Redundant", source="NCIT:C4648/inferred"} ! tongue cancer +is_a: MONDO:0004958 {source="DOID:0050865", source="MONDO:Redundant", source="NCIT:C4648"} ! oral cavity squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001723 ! tongue +property_value: exactMatch DOID:0050865 +property_value: exactMatch http://identifiers.org/snomedct/276952000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349566 +property_value: exactMatch NCIT:C4648 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0000510 +name: synucleinopathy +def: "A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. [url:http://en.wikipedia.org/wiki/Synucleinopathies ]" [DOID:0050890] +synonym: "alpha synucleinopathies" RELATED [DOID:0050890] +synonym: "synucleinopathies" RELATED [DOID:0050890] +xref: DOID:0050890 {source="MONDO:equivalentTo"} +xref: MESH:D000080874 {source="MONDO:equivalentTo"} +xref: UMLS:C5191670 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 ! inborn errors of metabolism +is_a: MONDO:0021179 {source="MESH:D000080874", source="UMLS:C5191670"} ! proteostasis deficiencies +is_a: MONDO:0024237 ! inherited neurodegenerative disorder +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11138 ! SNCA +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11138 ! SNCA +property_value: exactMatch DOID:0050890 +property_value: exactMatch http://identifiers.org/mesh/D000080874 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C5191670 + +[Term] +id: MONDO:0000514 +name: bone squamous cell carcinoma +def: "A squamous cell carcinoma that involves the bone tissue." [MONDO:patterns/location] +synonym: "bone tissue squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050896 {source="MONDO:equivalentTo"} +is_a: MONDO:0002415 {source="DOID:0050896", source="MONDO:Entailed", source="MONDO:Redundant"} ! bone carcinoma +is_a: MONDO:0005096 ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +property_value: exactMatch DOID:0050896 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0000517 +name: brain stem medulloblastoma +def: "A medulloblastoma that involves the brainstem." [MONDO:patterns/location] +synonym: "brainstem medulloblastoma" EXACT [MONDO:patterns/location] +synonym: "medulloblastoma of brainstem" EXACT [MONDO:design_pattern] +xref: DOID:0050899 {source="MONDO:equivalentTo"} +is_a: MONDO:0007959 {source="DOID:0050899", source="MONDO:Entailed", source="MONDO:Redundant"} ! medulloblastoma +is_a: MONDO:0021228 ! brainstem neoplasm +intersection_of: MONDO:0007959 ! medulloblastoma +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch DOID:0050899 +property_value: excluded_subClassOf MONDO:0002912 {source="DOID:0050899"} + +[Term] +id: MONDO:0000520 +name: parietal lobe ependymal tumor +def: "An ependymal tumor affecting the parietal lobe of the brain." [NCIT:C131575] +synonym: "ependymal tumor of parietal lobe" EXACT [MONDO:design_pattern] +synonym: "parietal lobe ependymal tumor" EXACT [MONDO:patterns/location, NCIT:C131575] +synonym: "parietal lobe ependymoma" RELATED [DOID:0050903] +xref: DOID:0050903 {source="MONDO:equivalentTo"} +xref: NCIT:C131575 {source="MONDO:equivalentTo"} +xref: UMLS:C4330935 {source="MONDO:equivalentTo"} +is_a: MONDO:0001952 ! parietal lobe cancer +is_a: MONDO:0004245 {source="MONDO:Redundant", source="NCIT:C131575"} ! ependymal tumor of brain +intersection_of: MONDO:0003266 ! ependymal tumor +intersection_of: disease_has_location UBERON:0001872 ! parietal lobe +property_value: exactMatch DOID:0050903 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4330935 +property_value: exactMatch NCIT:C131575 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0000521 +name: salivary gland carcinoma +def: "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma." [NCIT:C9272] +synonym: "carcinoma of saliva-secreting gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of salivary gland" EXACT [NCIT:C9272] +synonym: "carcinoma of the salivary gland" EXACT [NCIT:C9272] +synonym: "saliva-secreting gland carcinoma" EXACT [MONDO:patterns/location] +synonym: "salivary carcinoma" RELATED [ONCOTREE:SACA] +synonym: "salivary gland cancer" BROAD [NCIT:C9272] +synonym: "salivary gland carcinoma" EXACT [NCIT:C9272] +xref: DOID:0050904 {source="MONDO:equivalentTo"} +xref: NCIT:C9272 {source="MONDO:equivalentTo"} +xref: ONCOTREE:SACA {source="MONDO:equivalentTo"} +xref: UMLS:C0948750 {source="MONDO:equivalentTo", source="NCIT:C9272"} +is_a: MONDO:0004669 {source="DOID:0050904", source="MONDO:Redundant", source="NCIT:C9272"} ! salivary gland cancer +is_a: MONDO:0044925 ! oral cavity carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch DOID:0050904 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0948750 +property_value: exactMatch NCIT:C9272 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0000535 +name: tonsil squamous cell carcinoma +def: "A squamous cell carcinoma that involves the tonsil." [MONDO:patterns/location] +synonym: "tonsil squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050920 {source="MONDO:equivalentTo"} +is_a: MONDO:0021337 ! tonsil carcinoma +is_a: MONDO:0044704 ! oropharynx squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002372 ! tonsil +property_value: exactMatch DOID:0050920 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0000536 +name: pharyngeal squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the pharynx." [NCIT:C102872] +synonym: "pharyngeal (including hypopharyngeal and oropharyngeal) squamous cell carcinoma" EXACT [NCIT:C102872] +synonym: "pharyngeal squam. cell carcinoma" EXACT [NCIT:C102872] +synonym: "pharyngeal squamous cell carcinoma" EXACT [NCIT:C102872] +synonym: "pharyngeal throat squamous cell cancer" EXACT [NCIT:C102872] +synonym: "pharynx squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050921 {source="MONDO:equivalentTo"} +xref: EFO:1001965 {source="MONDO:equivalentTo"} +xref: NCIT:C102872 {source="MONDO:equivalentTo"} +xref: SCTID:408649007 {source="MONDO:equivalentTo"} +xref: UMLS:C1319317 {source="MONDO:equivalentTo"} +is_a: MONDO:0005517 {source="DOID:0050921", source="EFO:1001965", source="MONDO:Redundant", source="NCIT:C102872/inferred"} ! pharynx cancer +is_a: MONDO:0010150 {source="MONDO:Redundant", source="NCIT:C102872"} ! head and neck squamous cell carcinoma +is_a: MONDO:0021345 {source="MONDO:Redundant", source="NCIT:C102872"} ! carcinoma of pharynx +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001042 ! chordate pharynx +intersection_of: disease_has_location UBERON:0006562 ! pharynx +property_value: exactMatch DOID:0050921 +property_value: exactMatch http://identifiers.org/snomedct/408649007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1319317 +property_value: exactMatch NCIT:C102872 + +[Term] +id: MONDO:0000540 +name: small intestinal neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C4638] +synonym: "carcinoid tumor of small bowel" EXACT [NCIT:C4638] +synonym: "carcinoid tumor of small intestine" EXACT [NCIT:C4638] +synonym: "carcinoid tumor of the small bowel" EXACT [NCIT:C4638] +synonym: "carcinoid tumor of the small intestine" EXACT [NCIT:C4638] +synonym: "grade 1 neuroendocrine neoplasm of small intestine" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "small bowel carcinoid tumor" EXACT [NCIT:C4638] +synonym: "small intestinal carcinoid tumor" EXACT [NCIT:C4638] +synonym: "small intestinal NET G1" EXACT [NCIT:C4638] +synonym: "small intestinal neuroendocrine tumor G1" EXACT [NCIT:C4638] +synonym: "small intestine carcinoid neuroendocrine tumor" RELATED [DOID:0050925] +synonym: "small intestine carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C4638] +synonym: "small intestine carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "small intestine NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "small intestine neuroendocrine neoplasm G1" EXACT [] +synonym: "small intestine neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: DOID:0050925 {source="MONDO:equivalentTo"} +xref: NCIT:C4638 {source="MONDO:equivalentTo"} +xref: SCTID:276818002 {source="MONDO:equivalentTo"} +xref: UMLS:C0349536 {source="MONDO:equivalentTo", source="NCIT:C4638"} +is_a: MONDO:0002995 {source="MONDO:Redundant", source="NCIT:C4638"} ! small intestine neuroendocrine tumor, well differentiated, low or intermediate grade +is_a: MONDO:0021533 {source="MONDO:Redundant", source="NCIT:C4638"} ! intestinal neuroendocrine tumor G1 +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002108 ! small intestine +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch DOID:0050925 +property_value: exactMatch http://identifiers.org/snomedct/276818002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349536 +property_value: exactMatch NCIT:C4638 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0000541 +name: jejunal adenocarcinoma +def: "A adenocarcinoma that involves the jejunum." [MONDO:patterns/location] +synonym: "jejunal adenocarcinoma" EXACT [MONDO:ambiguous] +synonym: "jejunal adenocarcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "jejunum adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050926 {source="MONDO:equivalentTo"} +xref: HP:0030411 {source="MONDO:otherHierarchy"} +xref: UMLS:C4072935 {source="MONDO:equivalentTo"} +is_a: MONDO:0003198 ! small intestine adenocarcinoma +is_a: MONDO:0006815 ! jejunal cancer +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002115 ! jejunum +property_value: exactMatch DOID:0050926 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4072935 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: IAO:0000589 "jejunal adenocarcinoma (disease)" xsd:string + +[Term] +id: MONDO:0000552 +name: breast lobular carcinoma +def: "An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal." [NCIT:C3771] +synonym: "carcinoma of lobule of mammary gland" EXACT [MONDO:patterns/carcinoma] +synonym: "lobular adenocarcinoma" EXACT [NCIT:C3771] +synonym: "lobular breast carcinoma" EXACT [NCIT:C3771] +synonym: "lobular carcinoma" EXACT [NCIT:C3771] +synonym: "lobular carcinoma of breast" EXACT [NCIT:C3771] +synonym: "lobular carcinoma of the breast" EXACT [NCIT:C3771] +synonym: "lobule of mammary gland carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050938 {source="MONDO:equivalentTo"} +xref: EFO:0008509 {source="MONDO:equivalentTo"} +xref: ICDO:8520/3 {source="NCIT:C3771"} +xref: NCIT:C3771 {source="MONDO:equivalentTo"} +xref: SCTID:278054005 {source="MONDO:equivalentTo"} +is_a: MONDO:0004988 {source="NCIT:C3771"} ! breast adenocarcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001912 ! lobule of mammary gland +relationship: disease_has_location UBERON:0001912 ! lobule of mammary gland +property_value: exactMatch DOID:0050938 +property_value: exactMatch http://identifiers.org/snomedct/278054005 +property_value: exactMatch NCIT:C3771 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0000554 +name: endocervical adenocarcinoma +def: "An adenocarcinoma that arises from the endocervix. It is the most common type of endocervical adenocarcinoma. The neoplastic epithelium shows a pseudostratified architecture and the malignant cells have enlarged, elongated, and hyperchromatic nuclei." [NCIT:C127907] +synonym: "endocervical adenocarcinoma, usual type" EXACT [NCIT:C127907] +synonym: "endocervix adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:0050940 {source="MONDO:equivalentTo"} +xref: NCIT:C127907 {source="MONDO:equivalentTo"} +xref: ONCOTREE:ECAD {source="MONDO:equivalentTo"} +xref: SCTID:123842006 {source="MONDO:equivalentTo"} +xref: UMLS:C1263762 {source="MONDO:equivalentTo"} +xref: UMLS:C4289591 {source="MONDO:equivalentTo"} +is_a: MONDO:0004259 {source="DOID:0050940", source="MONDO:Redundant", source="NCIT:C127907"} ! endocervical carcinoma +is_a: MONDO:0005153 {source="NCIT:C127907", source="ONCOTREE:ECAD"} ! cervical adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000458 ! endocervix +property_value: exactMatch DOID:0050940 +property_value: exactMatch http://identifiers.org/snomedct/123842006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263762 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4289591 +property_value: exactMatch NCIT:C127907 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0000565 +name: infective endocarditis +def: "Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue." [https://rarediseases.info.nih.gov/diseases/6337/infective-endocarditis] +subset: gard_rare {source="GARD:0006337"} +synonym: "endocarditis infective" EXACT [NCIT:C78265] +synonym: "endocarditis, infective" RELATED [GARD:0006337] +xref: DOID:0060000 {source="MONDO:equivalentTo"} +xref: GARD:0006337 {source="MONDO:equivalentTo"} +xref: ICD9:136.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C78265 {source="MONDO:equivalentTo"} +xref: Orphanet:570762 {source="MONDO:equivalentTo"} +xref: SCTID:233850007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005025 {source="DOID:0060000", source="MONDO:Redundant", source="NCIT:C78265"} ! endocarditis +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0002165 ! endocardium +property_value: exactMatch DOID:0060000 +property_value: exactMatch http://identifiers.org/snomedct/233850007 +property_value: exactMatch NCIT:C78265 +property_value: exactMatch Orphanet:570762 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6337/infective-endocarditis xsd:anyURI {source="GARD:0006337"} + +[Term] +id: MONDO:0000568 +name: autoimmune disorder of central nervous system +def: "A hypersensitivity reaction type II disease that involves the central nervous system." [MONDO:patterns/location] +synonym: "central nervous system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "central nervous system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060004 {source="MONDO:equivalentTo"} +is_a: MONDO:0002602 {source="DOID:0060004", source="MONDO:Redundant"} ! central nervous system disorder +is_a: MONDO:0002977 {source="DOID:0060004", source="MONDO:Redundant"} ! autoimmune disorder of the nervous system +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:0060004 + +[Term] +id: MONDO:0000569 +name: autoimmune disorder of endocrine system +def: "A hypersensitivity reaction type II disease that involves the endocrine system." [MONDO:patterns/location] +synonym: "endocrine system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "endocrine system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060005 {source="MONDO:equivalentTo"} +xref: ICD9:279.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:237822008 {source="MONDO:equivalentTo"} +xref: UMLS:C0342552 {source="MONDO:equivalentTo"} +is_a: MONDO:0005151 {source="DOID:0060005", source="MONDO:Redundant"} ! endocrine system disorder +is_a: MONDO:0007179 {source="DOID:0060005", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0000949 ! endocrine system +property_value: exactMatch DOID:0060005 +property_value: exactMatch http://identifiers.org/snomedct/237822008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342552 + +[Term] +id: MONDO:0000577 +name: congenital anemia +def: "Anemia, the cause of which is present at birth." [NCIT:C35228] +synonym: "congenital anemia" EXACT [NCIT:C35228] +synonym: "congenital anemia (disease)" EXACT [MONDO:patterns/congenital] +xref: NCIT:C35228 {source="MONDO:equivalentTo"} +xref: SCTID:63565007 {source="MONDO:equivalentTo"} +xref: UMLS:C0158995 {source="MONDO:equivalentTo"} +is_a: MONDO:0002280 ! anemia +is_a: MONDO:0009332 {source="NCIT:C35228"} ! congenital hematological disorder +intersection_of: MONDO:0002280 ! anemia +intersection_of: has_modifier MONDO:0021140 ! congenital +property_value: exactMatch http://identifiers.org/snomedct/63565007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0158995 +property_value: exactMatch NCIT:C35228 + +[Term] +id: MONDO:0000586 +name: autoimmune disorder of exocrine system +def: "A hypersensitivity reaction type II disease that involves the exocrine system." [MONDO:patterns/location] +synonym: "exocrine system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "exocrine system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060029 {source="MONDO:equivalentTo"} +is_a: MONDO:0007179 {source="DOID:0060029", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0002330 ! exocrine system +relationship: disease_has_location UBERON:0002330 ! exocrine system +property_value: exactMatch DOID:0060029 + +[Term] +id: MONDO:0000587 +name: autoimmune disease of ear, nose and throat +def: "An autoimmune form of otorhinolaryngologic disease." [MONDO:patterns/autoimmune] +comment: Editor note: ENT typically excludes eye, but the DOID class includes this +synonym: "autoimmune disease of eyes, ear, nose and throat" RELATED [DOID:0060030] +synonym: "autoimmune otorhinolaryngologic disease" EXACT [MONDO:cjm] +xref: DOID:0060030 {source="MONDO:equivalentTo"} +is_a: MONDO:0007179 {source="DOID:0060030", source="MONDO:Redundant"} ! autoimmune disease +is_a: MONDO:0024623 ! otorhinolaryngologic disease +intersection_of: MONDO:0024623 ! otorhinolaryngologic disease +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0060030 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0000588 +name: autoimmune disorder of gastrointestinal tract +def: "A hypersensitivity reaction type II disease that involves the alimentary part of gastrointestinal system." [MONDO:patterns/location] +synonym: "alimentary part of gastrointestinal system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "alimentary part of gastrointestinal system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +synonym: "autoimmune disease of alimentary part of gastrointestinal system" EXACT [MONDO:design_pattern] +xref: DOID:0060031 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 ! digestive system disorder +is_a: MONDO:0007179 {source="DOID:0060031", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +property_value: exactMatch DOID:0060031 + +[Term] +id: MONDO:0000589 +name: autoimmune disorder of musculoskeletal system +def: "A hypersensitivity reaction type II disease that involves the musculoskeletal system." [MONDO:patterns/location] +synonym: "musculoskeletal system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "musculoskeletal system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060032 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 {source="DOID:0060032", source="MONDO:Entailed", source="MONDO:Redundant"} ! musculoskeletal system disorder +is_a: MONDO:0007179 {source="DOID:0060032", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0002204 ! musculoskeletal system +property_value: exactMatch DOID:0060032 + +[Term] +id: MONDO:0000590 +name: autoimmune disorder of peripheral nervous system +def: "A hypersensitivity reaction type II disease that involves the peripheral nervous system." [MONDO:patterns/location] +synonym: "peripheral nervous system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "peripheral nervous system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060033 {source="MONDO:equivalentTo"} +is_a: MONDO:0002977 {source="DOID:0060033", source="MONDO:Redundant"} ! autoimmune disorder of the nervous system +is_a: MONDO:0003620 {source="DOID:0060033", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0000010 ! peripheral nervous system +property_value: exactMatch DOID:0060033 + +[Term] +id: MONDO:0000591 +name: intrinsic cardiomyopathy +def: "A cardiomyopathy that is due to abnormalities in heart muscle cells." [https://www.emedicinehealth.com/cardiomyopathy/article_em.htm, Wikipedia:Cardiomyopathy] +synonym: "intrinsic cardiomyopathy" EXACT [] +synonym: "primary cardiomyopathy" EXACT [Wikipedia:Cardiomyopathy] +xref: DOID:0060036 {source="MONDO:equivalentTo"} +is_a: MONDO:0004994 {source="DOID:0060036", source="MONDO:Entailed", source="MONDO:Redundant"} ! cardiomyopathy +intersection_of: MONDO:0004994 ! cardiomyopathy +intersection_of: disease_arises_from_structure CL:0002494 ! cardiocyte +disjoint_from: MONDO:0002824 ! extrinsic cardiomyopathy +relationship: disease_arises_from_structure CL:0002494 ! cardiocyte +property_value: exactMatch DOID:0060036 + +[Term] +id: MONDO:0000601 +name: autoimmune disorder of urogenital tract +def: "A hypersensitivity reaction type II disease that involves the genitourinary system." [MONDO:patterns/location] +comment: Reason: grouping class. Term to consider: none +subset: obsoletion_candidate +synonym: "autoimmune disease of genitourinary system" EXACT [MONDO:design_pattern] +synonym: "genitourinary system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "genitourinary system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060049 {source="MONDO:equivalentTo"} +is_a: MONDO:0007179 {source="DOID:0060049", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0004122 ! genitourinary system +relationship: disease_has_location UBERON:0004122 ! genitourinary system +property_value: exactMatch DOID:0060049 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5024 + +[Term] +id: MONDO:0000602 +name: autoimmune disorder of blood +def: "A hypersensitivity reaction type II disease that involves the blood." [MONDO:patterns/location] +synonym: "blood autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "blood hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060050 {source="MONDO:equivalentTo"} +is_a: MONDO:0005570 ! hematologic disorder +is_a: MONDO:0007179 {source="DOID:0060050", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0000178 ! blood +relationship: disease_has_location UBERON:0000178 ! blood +property_value: exactMatch DOID:0060050 + +[Term] +id: MONDO:0000603 +name: autoimmune disorder of cardiovascular system +def: "A hypersensitivity reaction type II disease that involves the cardiovascular system." [MONDO:patterns/location] +synonym: "cardiovascular system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "cardiovascular system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +xref: DOID:0060051 {source="MONDO:equivalentTo"} +is_a: MONDO:0004995 {source="DOID:0060051", source="MONDO:Entailed", source="MONDO:Redundant"} ! cardiovascular disorder +is_a: MONDO:0007179 {source="DOID:0060051", source="MONDO:Entailed", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0004535 ! cardiovascular system +property_value: exactMatch DOID:0060051 + +[Term] +id: MONDO:0000605 +name: hypersensitivity reaction disease +def: "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [ISBN-13:978-0-7817-3514-8] +synonym: "allergic reaction" BROAD [NCIT:C3114] +synonym: "hypersensitive" EXACT [NCIT:C3114] +synonym: "hypersensitivity" EXACT [NCIT:C3114] +synonym: "hypersensitivity reaction" EXACT [NCIT:C3114] +synonym: "sensitive" BROAD [NCIT:C3114] +synonym: "sensitivity" BROAD [NCIT:C3114] +xref: DOID:0060056 {source="MONDO:equivalentTo"} +xref: EFO:1002003 {source="MONDO:equivalentTo"} +xref: NCIT:C3114 {source="MONDO:equivalentTo"} +xref: SCTID:473010000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005046 {source="DOID:0060056", source="EFO:1002003", source="MONDO:Redundant", source="NCIT:C3114"} ! immune system disorder +intersection_of: MONDO:0005046 ! immune system disorder +intersection_of: disease_has_basis_in_disruption_of GO:0002524 ! hypersensitivity +relationship: disease_has_basis_in_disruption_of GO:0002524 ! hypersensitivity +property_value: exactMatch DOID:0060056 +property_value: exactMatch http://identifiers.org/snomedct/473010000 +property_value: exactMatch NCIT:C3114 + +[Term] +id: MONDO:0000612 +name: lymphatic system cancer +def: "A malignant neoplasm involving the lymphatic part of lymphoid system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of lymphatic part of lymphoid system" EXACT [MONDO:patterns/cancer] +synonym: "lymphatic part of lymphoid system cancer" EXACT [MONDO:patterns/location] +synonym: "malignant lymphatic part of lymphoid system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of lymphatic part of lymphoid system" EXACT [MONDO:patterns/cancer] +xref: DOID:0060073 {source="MONDO:equivalentTo"} +is_a: MONDO:0000621 {source="DOID:0060073", source="MONDO:Entailed", source="MONDO:Redundant"} ! immune system cancer +is_a: MONDO:0005833 {source="DOID:0060073", source="MONDO:Entailed", source="MONDO:Redundant"} ! lymphatic system disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0006558 ! lymphatic part of lymphoid system +property_value: exactMatch DOID:0060073 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000620 +name: breast benign neoplasm +def: "A non-metastasizing neoplasm arising from the breast parenchyma." [NCIT:P378] +synonym: "benign breast neoplasm" EXACT [NCIT:C4505] +synonym: "benign breast tumor" EXACT [NCIT:C4505] +synonym: "benign neoplasm of breast" EXACT [NCIT:C4505] +synonym: "benign neoplasm of the breast" EXACT [NCIT:C4505] +synonym: "benign tumor of breast" EXACT [NCIT:C4505] +synonym: "benign tumor of the breast" EXACT [NCIT:C4505] +synonym: "breast benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060082 {source="MONDO:equivalentTo"} +xref: ICD9:217 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4505 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:269485000 {source="MONDO:equivalentTo"} +is_a: MONDO:0000634 {source="DOID:0060082", source="MONDO:Redundant"} ! thoracic benign neoplasm +is_a: MONDO:0021100 {source="MONDO:Redundant", source="NCIT:C4505"} ! breast neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:0060082 +property_value: exactMatch http://identifiers.org/snomedct/269485000 +property_value: exactMatch NCIT:C4505 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000621 +name: immune system cancer +def: "A malignant neoplasm involving the immune system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of immune system" EXACT [MONDO:patterns/cancer] +synonym: "immune system cancer" EXACT [MONDO:patterns/location] +synonym: "malignant immune system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of immune system" EXACT [MONDO:patterns/cancer] +xref: DOID:0060083 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:0060083", source="DOID:0060083/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0005046 {source="DOID:0060083", source="MONDO:Entailed", source="MONDO:Redundant"} ! immune system disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002405 ! immune system +property_value: exactMatch DOID:0060083 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000624 +name: benign female reproductive system neoplasm +def: "A non-metastasizing neoplasm that arises from the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, and benign ovarian germ cell tumor." [NCIT:C4934] +synonym: "benign female reproductive system neoplasm" EXACT [NCIT:C4934] +synonym: "benign female reproductive system tumor" EXACT [NCIT:C4934] +synonym: "benign gynecologic neoplasm" EXACT [NCIT:C4934] +synonym: "benign gynecologic tumor" EXACT [NCIT:C4934] +synonym: "female reproductive organ benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060086 {source="MONDO:equivalentTo"} +xref: NCIT:C4934 {source="MONDO:equivalentTo"} +xref: UMLS:C0744514 {source="MONDO:equivalentTo"} +is_a: MONDO:0000383 {source="DOID:0060086", source="MONDO:Redundant", source="NCIT:C4934"} ! benign reproductive system neoplasm +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C4934"} ! female reproductive system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003134 ! female reproductive organ +relationship: disease_has_location UBERON:0003134 ! female reproductive organ +property_value: exactMatch DOID:0060086 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0744514 +property_value: exactMatch NCIT:C4934 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000625 +name: benign male reproductive system neoplasm +def: "A non-metastasizing neoplasm that arises from the male reproductive system. Representative examples include benign prostate phyllodes tumor, benign Sertoli cell tumor, seminal vesicle cystadenoma, and epididymal adenomatoid tumor." [NCIT:C4777] +synonym: "benign Male reproductive system neoplasm" EXACT [NCIT:C4777] +synonym: "benign Male reproductive system tumor" EXACT [NCIT:C4777] +synonym: "male reproductive organ benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060087 {source="MONDO:equivalentTo"} +xref: NCIT:C4777 {source="MONDO:equivalentTo"} +xref: UMLS:C0947786 {source="MONDO:equivalentTo", source="NCIT:C4777"} +is_a: MONDO:0000383 {source="DOID:0060087", source="MONDO:Redundant", source="NCIT:C4777"} ! benign reproductive system neoplasm +is_a: MONDO:0003150 ! male reproductive system disorder +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000079 ! male reproductive system +property_value: exactMatch DOID:0060087 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0947786 +property_value: exactMatch NCIT:C4777 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000626 +name: vestibular gland benign neoplasm +def: "A benign neoplasm that involves the vestibular gland." [MONDO:patterns/location] +synonym: "vestibular gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060088 {source="MONDO:equivalentTo"} +is_a: MONDO:0000643 ! vulvar benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0011826 ! vestibular gland +relationship: disease_has_location UBERON:0011826 ! vestibular gland +property_value: exactMatch DOID:0060088 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000627 +name: benign endocrine neoplasm +def: "A non-metastasizing, functioning or non-functioning neoplasm that arises from an endocrine organ. Representative examples include thyroid gland follicular adenoma and parathyroid gland adenoma." [NCIT:C4621] +synonym: "benign endocrine gland neoplasm" EXACT [NCIT:C4621] +synonym: "benign endocrine gland tumor" EXACT [NCIT:C4621] +synonym: "benign endocrine neoplasm" EXACT [NCIT:C4621] +synonym: "benign endocrine tumor" EXACT [NCIT:C4621] +synonym: "benign neoplasm of endocrine gland" EXACT [NCIT:C4621] +synonym: "benign neoplasm of the endocrine gland" EXACT [NCIT:C4621] +synonym: "benign tumor of endocrine gland" EXACT [NCIT:C4621] +synonym: "benign tumor of the endocrine gland" EXACT [NCIT:C4621] +synonym: "endocrine gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "endocrine organ benign neoplasm" EXACT [DOID:0060089] +xref: DOID:0060089 {source="MONDO:equivalentTo"} +xref: ICD9:227.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:227.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4621 {source="MONDO:equivalentTo"} +xref: SCTID:92085000 {source="MONDO:equivalentTo"} +xref: UMLS:C0347524 {source="MONDO:equivalentTo", source="NCIT:C4621"} +is_a: MONDO:0002082 {source="MONDO:Redundant", source="NCIT:C4621"} ! endocrine gland neoplasm +is_a: MONDO:0005165 {source="DOID:0060089", source="DOID:0060089/inferred", source="MONDO:Redundant"} ! benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002368 ! endocrine gland +property_value: exactMatch DOID:0060089 +property_value: exactMatch http://identifiers.org/snomedct/92085000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347524 +property_value: exactMatch NCIT:C4621 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000628 +name: central nervous system organ benign neoplasm +def: "A benign neoplasm that involves the central nervous system." [MONDO:patterns/location] +synonym: "central nervous system benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060090 {source="MONDO:equivalentTo"} +is_a: MONDO:0000648 {source="DOID:0060090", source="MONDO:Redundant"} ! nervous system benign neoplasm +is_a: MONDO:0006130 ! central nervous system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:0060090 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000629 +name: cardiovascular organ benign neoplasm +def: "A benign neoplasm that involves the cardiovascular system." [MONDO:patterns/location] +synonym: "cardiovascular system benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060091 {source="MONDO:equivalentTo"} +is_a: MONDO:0005165 {source="DOID:0060091", source="DOID:0060091/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0024757 ! cardiovascular neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0004535 ! cardiovascular system +property_value: exactMatch DOID:0060091 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000630 +name: immune system organ benign neoplasm +def: "A benign neoplasm that involves the immune organ." [MONDO:patterns/location] +synonym: "immune organ benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060092 {source="MONDO:equivalentTo"} +is_a: MONDO:0005046 ! immune system disorder +is_a: MONDO:0005165 {source="DOID:0060092", source="DOID:0060092/inferred", source="MONDO:Redundant"} ! benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0005057 ! immune organ +relationship: disease_has_location UBERON:0005057 ! immune organ +property_value: exactMatch DOID:0060092 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000631 +name: bone benign neoplasm +def: "A neoplasm that arises from the bone or articular cartilage and does not invade adjacent tissues or metastasize to other anatomic sites." [NCIT:P378] +synonym: "benign bone neoplasm" EXACT [NCIT:C4880] +synonym: "benign bone tumor" EXACT [NCIT:C4880] +synonym: "benign neoplasm of bone" EXACT [NCIT:C4880] +synonym: "benign neoplasm of the bone" EXACT [NCIT:C4880] +synonym: "benign osseous neoplasm" EXACT [NCIT:C4880] +synonym: "benign osseous tumor" EXACT [NCIT:C4880] +synonym: "benign tumor of bone" EXACT [NCIT:C4880] +synonym: "benign tumor of the bone" EXACT [NCIT:C4880] +synonym: "bone tissue benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060094 {source="MONDO:equivalentTo"} +xref: ICD9:213.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4880 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92027006 {source="MONDO:equivalentTo"} +is_a: MONDO:0000654 {source="DOID:0060094", source="MONDO:Entailed", source="NCIT:C4880"} ! benign connective and soft tissue neoplasm +is_a: MONDO:0019060 ! bone neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +property_value: exactMatch DOID:0060094 +property_value: exactMatch http://identifiers.org/snomedct/92027006 +property_value: exactMatch NCIT:C4880 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000632 +name: uterine benign neoplasm +def: "A non-metastasizing neoplasm that arises from the uterine corpus or the cervix. Representative examples include leiomyoma, adenomyoma, and endocervical polyp." [NCIT:P378] +synonym: "benign neoplasm of the uterus" EXACT [NCIT:C3609] +synonym: "benign neoplasm of uterus" EXACT [NCIT:C3609] +synonym: "benign tumor of the uterus" EXACT [NCIT:C3609] +synonym: "benign tumor of uterus" EXACT [NCIT:C3609] +synonym: "benign uterine neoplasm" EXACT [NCIT:C3609] +synonym: "benign uterine neoplasms" EXACT [NCIT:C3609] +synonym: "benign uterine tumor" EXACT [NCIT:C3609] +synonym: "benign uterine tumors" EXACT [NCIT:C3609] +synonym: "benign uterus neoplasm" EXACT [NCIT:C3609] +synonym: "benign uterus neoplasms" EXACT [NCIT:C3609] +synonym: "benign uterus tumor" EXACT [NCIT:C3609] +synonym: "benign uterus tumors" EXACT [NCIT:C3609] +synonym: "uterine neoplasms, benign" EXACT [NCIT:C3609] +synonym: "uterine tumors, benign" EXACT [NCIT:C3609] +synonym: "Uterous neoplasms, benign" EXACT [NCIT:C3609] +synonym: "Uterous tumors, benign" EXACT [NCIT:C3609] +synonym: "uterus benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060095 {source="MONDO:equivalentTo"} +xref: ICD9:219.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:219.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3609 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92470003 {source="MONDO:equivalentTo"} +xref: UMLS:C0153999 {source="NCIT:C3609", source="MONDO:equivalentTo"} +is_a: MONDO:0000624 {source="DOID:0060095", source="MONDO:Entailed", source="NCIT:C3609"} ! benign female reproductive system neoplasm +is_a: MONDO:0021353 {source="MONDO:Redundant", source="NCIT:C3609"} ! tumor of uterus +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000995 ! uterus +property_value: exactMatch DOID:0060095 +property_value: exactMatch http://identifiers.org/snomedct/92470003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153999 +property_value: exactMatch NCIT:C3609 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000633 +name: sensory organ benign neoplasm +def: "A benign neoplasm that involves the sense organ." [MONDO:patterns/location] +synonym: "sense organ benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060096 {source="MONDO:equivalentTo"} +is_a: MONDO:0000648 {source="DOID:0060096", source="MONDO:Entailed", source="MONDO:Redundant"} ! nervous system benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000020 ! sense organ +relationship: disease_has_location UBERON:0000020 ! sense organ +property_value: exactMatch DOID:0060096 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000634 +name: thoracic benign neoplasm +alt_id: MONDO:0021448 +def: "A non-metastasizing neoplasm arising from any of the organs of the thoracic cavity. Representative examples include pleural adenomatoid tumor, chest wall lipoma, mediastinal schwannoma, and lung hamartoma." [NCIT:C4565] +synonym: "benign neoplasm of the thorax" EXACT [NCIT:C4565] +synonym: "benign neoplasm of thorax" EXACT [NCIT:C4565] +synonym: "benign thoracic neoplasm" EXACT [NCIT:C4565] +synonym: "benign thoracic tumor" EXACT [NCIT:C4565] +synonym: "benign tumor of the thorax" EXACT [NCIT:C4565] +synonym: "benign tumor of thorax" EXACT [NCIT:C4565] +synonym: "thoracic segment of trunk benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060097 {source="MONDO:equivalentTo"} +xref: ICD9:229.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4565 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:255059002 {source="MONDO:equivalentTo"} +xref: UMLS:C0346440 {source="MONDO:equivalentTo", source="NCIT:C4565"} +is_a: MONDO:0005165 {source="DOID:0060097", source="DOID:0060097/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C4565"} ! neoplasm of thorax +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000915 ! thoracic segment of trunk +property_value: exactMatch DOID:0060097 +property_value: exactMatch http://identifiers.org/snomedct/255059002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346440 +property_value: exactMatch NCIT:C4565 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000636 +name: musculoskeletal system benign neoplasm +def: "A benign neoplasm that involves the musculoskeletal system." [MONDO:patterns/location] +synonym: "musculoskeletal system benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060099 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 {source="DOID:0060099", source="MONDO:Entailed", source="MONDO:Redundant"} ! musculoskeletal system disorder +is_a: MONDO:0005165 {source="DOID:0060099", source="DOID:0060099/inferred", source="MONDO:Redundant"} ! benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002204 ! musculoskeletal system +property_value: exactMatch DOID:0060099 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000637 +name: musculoskeletal system cancer +def: "A malignant neoplasm involving the musculoskeletal system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of musculoskeletal system" EXACT [MONDO:patterns/cancer] +synonym: "malignant musculoskeletal system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of musculoskeletal system" EXACT [MONDO:patterns/cancer] +synonym: "musculoskeletal system cancer" EXACT [MONDO:patterns/location] +synonym: "skeletal system cancer" RELATED [DOID:0060100] +xref: DOID:0060100 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 {source="DOID:0060100", source="MONDO:Entailed", source="MONDO:Redundant"} ! musculoskeletal system disorder +is_a: MONDO:0004992 {source="DOID:0060100", source="DOID:0060100/inferred", source="MONDO:Redundant"} ! cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002204 ! musculoskeletal system +property_value: exactMatch DOID:0060100 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000638 +name: benign glioma +def: "A form of glioma without malignant characteristics." [MONDO:patterns/benign] +synonym: "glioma, benign" EXACT [MONDO:patterns/benign] +xref: DOID:0060101 {source="MONDO:equivalentObsolete"} +is_a: MONDO:0000648 ! nervous system benign neoplasm +is_a: MONDO:0021042 ! glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0000639 +name: cartilage cancer +def: "A cancer involving a cartilage tissue." [MONDO:patterns/cancer] +subset: gard_rare +synonym: "cancer of cartilage tissue" EXACT [MONDO:patterns/cancer] +synonym: "cartilage tissue cancer" EXACT [MONDO:patterns/location] +synonym: "cartilaginous cancer" EXACT [GARD:0006004] +synonym: "malignant cartilage tissue neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of cartilage tissue" EXACT [MONDO:patterns/cancer] +xref: DOID:0060102 {source="MONDO:equivalentTo"} +xref: GARD:0006004 {source="MONDO:equivalentTo"} +is_a: MONDO:0002129 ! bone cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002418 ! cartilage tissue +relationship: disease_has_location UBERON:0002418 ! cartilage tissue +property_value: exactMatch DOID:0060102 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6004/cartilaginous-cancer xsd:anyURI {source="GARD:0006004"} + +[Term] +id: MONDO:0000642 +name: brain meningioma +def: "A meningioma (disease) that involves the brain." [MONDO:patterns/location] +comment: Editor note: TODO check +synonym: "brain meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of brain" EXACT [] +xref: DOID:0060106 {source="MONDO:equivalentTo"} +is_a: MONDO:0016642 {source="DOID:0060106", source="MONDO:Redundant"} ! meningioma +is_a: MONDO:0021211 ! brain neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:0060106 +property_value: excluded_subClassOf MONDO:0001657 {source="DOID:0060106"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0000643 +name: vulvar benign neoplasm +def: "A non-metastasizing neoplasm that arises from the vulva. Representative examples include cellular angiofibroma, melanocytic nevus, nodular hidradenoma, and Bartholin gland adenoma." [NCIT:P378] +synonym: "benign neoplasm of the vulva" EXACT [NCIT:C3611] +synonym: "benign neoplasm of vulva" EXACT [NCIT:C3611] +synonym: "benign tumor of the vulva" EXACT [NCIT:C3611] +synonym: "benign tumor of vulva" EXACT [NCIT:C3611] +synonym: "benign vulva neoplasm" EXACT [NCIT:C3611] +synonym: "benign vulva tumor" EXACT [NCIT:C3611] +synonym: "benign vulval neoplasm" EXACT [NCIT:C3611] +synonym: "benign vulvar neoplasm" EXACT [NCIT:C3611] +synonym: "benign vulvar tumor" EXACT [NCIT:C3611] +synonym: "mammalian vulva benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "vulva benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060109 {source="MONDO:equivalentTo"} +xref: NCIT:C3611 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92486005 {source="MONDO:equivalentTo"} +xref: UMLS:C0154003 {source="MONDO:equivalentTo", source="NCIT:C3611"} +is_a: MONDO:0000624 {source="DOID:0060109", source="MONDO:Redundant", source="NCIT:C3611"} ! benign female reproductive system neoplasm +is_a: MONDO:0021049 {source="MONDO:Redundant", source="NCIT:C3611"} ! vulvar neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:0060109 +property_value: exactMatch http://identifiers.org/snomedct/92486005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154003 +property_value: exactMatch NCIT:C3611 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000644 +name: cervical benign neoplasm +def: "A non-metastasizing neoplasm that arises from the cervix. Representative examples include squamous papilloma, endocervical polyp, and rhabdomyoma." [NCIT:P378] +synonym: "benign cervical neoplasm" EXACT [NCIT:C3607] +synonym: "benign cervix uteri neoplasm" EXACT [NCIT:C3607] +synonym: "benign cervix uteri tumor" EXACT [NCIT:C3607] +synonym: "benign neoplasm of cervix uteri" EXACT [NCIT:C3607] +synonym: "benign neoplasm of the cervix uteri" EXACT [NCIT:C3607] +synonym: "benign neoplasm of the uterine cervix" EXACT [NCIT:C3607] +synonym: "benign neoplasm of uterine cervix" EXACT [NCIT:C3607] +synonym: "benign tumor of cervix uteri" EXACT [NCIT:C3607] +synonym: "benign tumor of the cervix uteri" EXACT [NCIT:C3607] +synonym: "benign tumor of the uterine cervix" EXACT [NCIT:C3607] +synonym: "benign tumor of uterine cervix" EXACT [NCIT:C3607] +synonym: "benign uterine cervix neoplasm" EXACT [NCIT:C3607] +synonym: "benign uterine cervix tumor" EXACT [NCIT:C3607] +synonym: "uterine cervix benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060110 {source="MONDO:equivalentTo"} +xref: NCIT:C3607 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92056006 {source="MONDO:equivalentTo"} +xref: UMLS:C0153997 {source="NCIT:C3607", source="MONDO:equivalentTo"} +is_a: MONDO:0000632 {source="MONDO:Redundant", source="NCIT:C3607"} ! uterine benign neoplasm +is_a: MONDO:0021230 {source="MONDO:Redundant", source="NCIT:C3607"} ! uterine cervix neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +property_value: exactMatch DOID:0060110 +property_value: exactMatch http://identifiers.org/snomedct/92056006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153997 +property_value: exactMatch NCIT:C3607 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000645 +name: fallopian tube benign neoplasm +def: "A non-metastasizing neoplasm that arises from the fallopian tube. Representative examples include papilloma, adenofibroma, and leiomyoma." [NCIT:P378] +subset: ordo_disease {source="Orphanet:180237"} +synonym: "benign fallopian tube neoplasm" EXACT [NCIT:C4517] +synonym: "benign fallopian tube tumor" EXACT [NCIT:C4517] +synonym: "benign neoplasm of fallopian tube" EXACT [NCIT:C4517] +synonym: "benign neoplasm of the fallopian tube" EXACT [NCIT:C4517] +synonym: "benign tumor of fallopian tube" EXACT [NCIT:C4517] +synonym: "benign tumor of fallopian tubes" EXACT [MONDO:0015865] +synonym: "benign tumor of the fallopian tube" EXACT [NCIT:C4517] +synonym: "fallopian tube benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "fallopian tube neoplasm, benign" EXACT [NCIT:C4517] +synonym: "fallopian tube tumor, benign" EXACT [NCIT:C4517] +xref: DOID:0060111 {source="MONDO:equivalentTo"} +xref: ICD10CM:D28.2 {source="Orphanet:180237/ntbt", source="Orphanet:180237"} +xref: MedDRA:10053865 {source="Orphanet:180237/e", source="Orphanet:180237"} +xref: NCIT:C4517 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:180237 {source="MONDO:equivalentTo"} +xref: SCTID:92100009 {source="MONDO:equivalentTo"} +xref: UMLS:C0346190 {source="Orphanet:180237/e", source="MONDO:equivalentTo", source="NCIT:C4517", source="Orphanet:180237"} +is_a: MONDO:0000624 {source="DOID:0060111", source="MONDO:Redundant", source="NCIT:C4517"} ! benign female reproductive system neoplasm +is_a: MONDO:0021092 {source="MONDO:Redundant", source="NCIT:C4517"} ! fallopian tube neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: closeMatch http://identifiers.org/meddra/10053865 +property_value: exactMatch DOID:0060111 +property_value: exactMatch http://identifiers.org/snomedct/92100009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346190 +property_value: exactMatch NCIT:C4517 +property_value: exactMatch Orphanet:180237 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml +property_value: narrowMatch https://icd.codes/icd10cm/D28.2 + +[Term] +id: MONDO:0000646 +name: ovarian benign neoplasm +def: "A non-metastasizing neoplasm that arises from the ovary. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, benign Brenner tumor, thecoma, and fibroma." [NCIT:P378] +synonym: "benign neoplasm of ovary" EXACT [NCIT:C2895] +synonym: "benign neoplasm of the ovary" EXACT [NCIT:C2895] +synonym: "benign ovarian neoplasm" EXACT [NCIT:C2895] +synonym: "benign ovarian tumor" EXACT [NCIT:C2895] +synonym: "benign tumor of ovary" EXACT [NCIT:C2895] +synonym: "benign tumor of the ovary" EXACT [NCIT:C2895] +synonym: "ovary benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060112 {source="MONDO:equivalentTo"} +xref: EFO:1000116 {source="MONDO:equivalentTo"} +xref: NCIT:C2895 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92260003 {source="MONDO:equivalentTo"} +is_a: MONDO:0000624 {source="DOID:0060112", source="MONDO:Redundant", source="NCIT:C2895"} ! benign female reproductive system neoplasm +is_a: MONDO:0021068 {source="MONDO:Redundant", source="NCIT:C2895"} ! ovarian neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:0060112 +property_value: exactMatch http://identifiers.org/snomedct/92260003 +property_value: exactMatch NCIT:C2895 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000647 +name: benign vaginal neoplasm +def: "A non-metastasizing neoplasm that arises from the vagina. Representative examples include squamous papilloma and melanocytic nevus." [NCIT:C3610] +synonym: "benign neoplasm of the vagina" EXACT [NCIT:C3610] +synonym: "benign neoplasm of vagina" EXACT [NCIT:C3610] +synonym: "benign tumor of the vagina" EXACT [NCIT:C3610] +synonym: "benign tumor of vagina" EXACT [NCIT:C3610] +synonym: "benign vaginal neoplasm" EXACT [NCIT:C3610] +synonym: "benign vaginal neoplasms" EXACT [NCIT:C3610] +synonym: "benign vaginal tumor" EXACT [NCIT:C3610] +synonym: "vagina benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "vagina female reproductive organ benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "vaginal benign neoplasm" EXACT [DOID:0060114] +xref: DOID:0060114 {source="MONDO:equivalentTo"} +xref: ICD9:221.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3610 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92473001 {source="MONDO:equivalentTo"} +xref: UMLS:C0154002 {source="MONDO:equivalentTo", source="NCIT:C3610"} +is_a: MONDO:0000624 {source="DOID:0060114", source="MONDO:Redundant", source="NCIT:C3610"} ! benign female reproductive system neoplasm +is_a: MONDO:0021050 {source="MONDO:Redundant", source="NCIT:C3610"} ! vaginal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch DOID:0060114 +property_value: exactMatch http://identifiers.org/snomedct/92473001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154002 +property_value: exactMatch NCIT:C3610 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000648 +name: nervous system benign neoplasm +def: "Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis (e.g., brainstem gliomas)." [NCIT:P378] +synonym: "benign neoplasm of nervous system" EXACT [NCIT:C4789] +synonym: "benign neoplasm of the nervous system" EXACT [NCIT:C4789] +synonym: "benign nervous system neoplasm" EXACT [NCIT:C4789] +synonym: "benign nervous system tumor" EXACT [NCIT:C4789] +synonym: "benign tumor of nervous system" EXACT [NCIT:C4789] +synonym: "benign tumor of the nervous system" EXACT [NCIT:C4789] +synonym: "nervous system benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "nervous system neoplasm, benign" EXACT [NCIT:C4789] +xref: DOID:0060115 {source="MONDO:equivalentTo"} +xref: ICD9:225.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:225.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4789 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92247009 {source="MONDO:equivalentTo"} +xref: UMLS:C0497550 {source="MONDO:equivalentTo", source="NCIT:C4789"} +is_a: MONDO:0005165 {source="DOID:0060115", source="DOID:0060115/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0021248 {source="MONDO:Redundant", source="NCIT:C4789"} ! nervous system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001016 ! nervous system +property_value: exactMatch DOID:0060115 +property_value: exactMatch http://identifiers.org/snomedct/92247009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0497550 +property_value: exactMatch NCIT:C4789 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000649 +name: sensory system cancer +def: "A malignant neoplasm involving the sensory system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of sensory system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sensory system" EXACT [MONDO:patterns/cancer] +synonym: "malignant sensory system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "sensory system cancer" EXACT [MONDO:patterns/location] +xref: DOID:0060116 {source="MONDO:equivalentTo"} +is_a: MONDO:0005872 {source="DOID:0060116", source="MONDO:Entailed", source="MONDO:Redundant"} ! nervous system cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001032 ! sensory system +relationship: disease_has_location UBERON:0001032 ! sensory system +property_value: exactMatch DOID:0060116 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000650 +name: peritoneal benign neoplasm +def: "A non-metastasizing neoplasm that arises from the peritoneal cavity. Representative examples include adenomatoid tumor and disseminated peritoneal leiomyomatosis." [NCIT:C8612] +synonym: "benign peritoneal neoplasm" EXACT [NCIT:C8612] +synonym: "peritoneum benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060117 {source="MONDO:equivalentTo"} +xref: NCIT:C8612 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0496874 {source="MONDO:equivalentTo", source="NCIT:C8612"} +is_a: MONDO:0005165 {source="DOID:0060117", source="DOID:0060117/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0006901 {source="MONDO:Redundant", source="NCIT:C8612"} ! peritoneal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002358 ! peritoneum +property_value: exactMatch DOID:0060117 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496874 +property_value: exactMatch NCIT:C8612 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000652 +name: integumentary system benign neoplasm +def: "A benign neoplasm that involves the integumental system." [MONDO:patterns/location] +synonym: "integumental system benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0060121 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 {source="DOID:0060121", source="MONDO:Entailed", source="MONDO:Redundant"} ! integumentary system disorder +is_a: MONDO:0005165 {source="DOID:0060121", source="DOID:0060121/inferred", source="MONDO:Redundant"} ! benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002416 ! integumental system +property_value: exactMatch DOID:0060121 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0000653 +name: integumentary system cancer +def: "A malignant neoplasm involving the integumental system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of integumental system" EXACT [MONDO:patterns/cancer] +synonym: "integumental system cancer" EXACT [MONDO:patterns/location] +synonym: "malignant integumental system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of integumental system" EXACT [MONDO:patterns/cancer] +xref: DOID:0060122 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 {source="DOID:0060122", source="MONDO:Entailed", source="MONDO:Redundant"} ! integumentary system disorder +is_a: MONDO:0004992 {source="DOID:0060122", source="DOID:0060122/inferred", source="MONDO:Redundant"} ! cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002416 ! integumental system +property_value: exactMatch DOID:0060122 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000654 +name: benign connective and soft tissue neoplasm +def: "A non-metastasizing neoplasm that arises from the connective and soft tissue. Representative examples include lipoma, leiomyoma, fibroma, and osteoma." [NCIT:C53684] +synonym: "benign connective and soft tissue neoplasm" EXACT [NCIT:C53684] +synonym: "benign connective and soft tissue tumor" EXACT [NCIT:C53684] +synonym: "benign mesenchymal cell neoplasm" EXACT [NCIT:C53684] +synonym: "benign neoplasm of the soft tissue and bone" EXACT [NCIT:C53684] +synonym: "benign tumor of the soft tissue and bone" EXACT [NCIT:C53684] +synonym: "connective and soft tissue neoplasm, benign" EXACT [MONDO:patterns/benign, NCIT:C53684] +synonym: "connective tissue benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "neoplasm of soft tissue" RELATED [DOID:0060123] +synonym: "neoplasm of soft tissues" RELATED [DOID:0060123] +synonym: "soft tissue benign neoplasm" RELATED [DOID:0060123] +synonym: "tumor of the soft tissue" RELATED [DOID:0060123, NCIT:C3377] +xref: DOID:0060123 {source="MONDO:equivalentTo"} +xref: NCIT:C3377 {source="DOID:0060123", source="MONDO:directSiblingOf"} +xref: NCIT:C53684 {source="MONDO:equivalentTo"} +xref: SCTID:387837005 {source="DOID:0060123", source="MONDO:directSiblingOf"} +is_a: MONDO:0000636 {source="DOID:0060123", source="MONDO:Entailed"} ! musculoskeletal system benign neoplasm +is_a: MONDO:0003900 {source="DOID:0060123", source="MONDO:Redundant"} ! connective tissue disorder +is_a: MONDO:0044334 {source="MONDO:Redundant", source="NCIT:C53684"} ! connective and soft tissue neoplasm +intersection_of: MONDO:0044334 ! connective and soft tissue neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:0060123 +property_value: exactMatch NCIT:C53684 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0000688 +name: inherited organic acidemia +def: "An inherited disorder that affects the metabolism of any acidic compound containing carbon in a covalent linkage." [NCIT:C101334] +subset: disease_grouping +subset: gard_rare {source="GARD:0009433"} +subset: ordo_group_of_disorders {source="Orphanet:289899"} +synonym: "disorder of organic acid metabolism" BROAD [NCIT:C101334] +synonym: "inborn error of organic acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn organic acid metabolic process disorder" EXACT [] +synonym: "organic acid metabolism disorder" BROAD [DOID:0060159] +synonym: "organic acidemia" RELATED [DOID:0060159, GARD:0009433] +synonym: "organic aciduria" RELATED [DOID:0060159, MONDO:0017358] +synonym: "rare inborn error of organic acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:0060159 {source="MONDO:equivalentTo"} +xref: GARD:0009433 {source="MONDO:equivalentTo"} +xref: ICD9:277.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C101334 {source="MONDO:equivalentTo"} +xref: Orphanet:289899 {source="MONDO:equivalentTo"} +xref: UMLS:C1263739 {source="MONDO:equivalentTo", source="NCIT:C101334"} +is_a: MONDO:0019189 ! inborn disorder of amino acid and other organic acid metabolism +is_a: MONDO:0045022 ! disorder of organic acid metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006082 ! organic acid metabolic process +property_value: exactMatch DOID:0060159 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263739 +property_value: exactMatch NCIT:C101334 +property_value: exactMatch Orphanet:289899 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9433/organic-acidemia xsd:anyURI {source="GARD:0009433"} + +[Term] +id: MONDO:0000706 +name: chemical colitis +def: "A colitis caused by the introduction of harsh chemicals to the colon by an enema or other procedure. Chemical colitis can resemble ulcerative colitis, infectious colitis and pseudomembranous colitis endoscopically." [http://en.wikipedia.org/wiki/Chemical_colitis] +xref: DOID:0060186 {source="MONDO:equivalentTo"} +xref: ICD9:558 {source="DOID:0060186"} +xref: ICD9:558.9 {source="DOID:0060186", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:72965009 {source="DOID:0060186", source="MONDO:equivalentTo"} +is_a: MONDO:0005292 {source="DOID:0060186", source="MONDO:Redundant"} ! colitis +intersection_of: MONDO:0005292 ! colitis +intersection_of: realized_in_response_to ECTO:0000231 ! exposure to chemical +relationship: realized_in_response_to ECTO:0000231 ! exposure to chemical +property_value: exactMatch DOID:0060186 +property_value: exactMatch http://identifiers.org/snomedct/72965009 + +[Term] +id: MONDO:0000721 +name: xanthinuria +def: "A metabolic metabolic disorder characterized by excess urinary excretion of the purine base xanthine." [https://www.sciencedirect.com/topics/medicine-and-dentistry/xanthinuria] +xref: ICD9:277.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:190919008 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_disrupts GO:0046110 ! xanthine metabolic process +relationship: disease_disrupts GO:0046110 ! xanthine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/190919008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0000732 +name: combined oxidative phosphorylation deficiency +def: "A mitochondrial oxidative phosphorylation disorder in which multiple mitochondrial respiratory chain complexes." [MONDO:cjm] +subset: gard_rare {source="GARD:0012893"} +xref: DOID:0060286 {source="MONDO:equivalentTo"} +xref: GARD:0012893 {source="MONDO:equivalentTo"} +xref: OMIMPS:609060 {source="MONDO:cjm", source="MONDO:equivalentTo"} +is_a: MONDO:0016387 {source="MONDO:cjm"} ! mitochondrial oxidative phosphorylation disorder +property_value: exactMatch DOID:0060286 +property_value: exactMatch https://omim.org/phenotypicSeries/PS609060 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/12893/combined-oxidative-phosphorylation-deficiency xsd:anyURI {source="GARD:0012893"} +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0000739 +name: uvulitis +def: "Inflammation of the uvula." [NCIT:C128385] +synonym: "acute uvulitis" NARROW [DOID:0060310] +synonym: "inflammation of palatine uvula" EXACT [] +synonym: "palatine uvula inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:0060310 {source="MONDO:equivalentTo"} +xref: ICD9:528.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10051962 {source="DOID:0060310"} +xref: NCIT:C128385 {source="MONDO:equivalentTo"} +xref: SCTID:300932000 {source="MONDO:equivalentTo"} +xref: UMLS:C0042174 {source="NCIT:C128385", source="MONDO:equivalentTo"} +is_a: MONDO:0004867 {source="DOID:0060310"} ! upper respiratory tract disorder +is_a: MONDO:0006858 {source="MONDO:Redundant", source="NCIT:C128385/inferred"} ! mouth disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001734 ! palatine uvula +relationship: disease_has_inflammation_site UBERON:0001734 ! palatine uvula +property_value: closeMatch http://identifiers.org/meddra/10051962 +property_value: exactMatch DOID:0060310 +property_value: exactMatch http://identifiers.org/snomedct/300932000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042174 +property_value: exactMatch NCIT:C128385 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000748 +name: mastoiditis +def: "Inflammation of the mucosal lining of the mastoid antrum and mastoid air cell system of the mastoid process." [NCIT:C128368] +synonym: "inflammation of mastoid process of temporal bone" EXACT [] +synonym: "mastoid process of temporal bone inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "mastoid process of temporal boneitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "mastoiditis" EXACT [MONDO:ambiguous] +synonym: "mastoiditis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:0060322 {source="MONDO:equivalentTo"} +xref: HP:0000265 {source="DOID:0060322", source="MONDO:otherHierarchy"} +xref: ICD9:383.9 {source="DOID:0060322", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D008417 {source="DOID:0060322", source="MONDO:equivalentTo"} +xref: NCIT:C128368 {source="MONDO:equivalentTo"} +xref: SCTID:52404001 {source="DOID:0060322", source="MONDO:equivalentTo"} +xref: UMLS:C0024904 {source="DOID:0060322", source="MONDO:equivalentTo", source="NCIT:C128368"} +is_a: MONDO:0002614 {source="DOID:0060322"} ! bone inflammation disease +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C128368"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0011220 ! mastoid process of temporal bone +relationship: disease_has_inflammation_site UBERON:0011220 ! mastoid process of temporal bone +property_value: exactMatch DOID:0060322 +property_value: exactMatch http://identifiers.org/mesh/D008417 +property_value: exactMatch http://identifiers.org/snomedct/52404001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024904 +property_value: exactMatch NCIT:C128368 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "mastoiditis (disease)" xsd:string + +[Term] +id: MONDO:0000766 +name: corneal endothelial dystrophy +def: "A corneal dystrophy (disease) that involves the corneal epithelium." [MONDO:design_pattern] +synonym: "corneal dystrophy (disease) of corneal epithelium" EXACT [] +synonym: "endothelial dystrophy" RELATED [DOID:0060443] +xref: DOID:0060443 {source="MONDO:equivalentTo"} +xref: ICD9:371.57 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:416960004 {source="MONDO:equivalentTo"} +is_a: MONDO:0018102 {source="DOID:0060443", source="MONDO:Redundant"} ! corneal dystrophy +intersection_of: MONDO:0018102 ! corneal dystrophy +intersection_of: disease_has_location UBERON:0001772 ! corneal epithelium +relationship: disease_has_location UBERON:0001772 ! corneal epithelium +property_value: exactMatch DOID:0060443 +property_value: exactMatch http://identifiers.org/snomedct/416960004 + +[Term] +id: MONDO:0000771 +name: allergic respiratory disease +def: "A respiratory system disease with a basis in a pathological type I hypersensitivity reaction." [MONDO:patterns/allergic_form_of_disease] +synonym: "airway allergy" EXACT [DOID:0060496] +synonym: "allergic form of respiratory system disease" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic respiratory system disease" EXACT [] +synonym: "respiratory allergy" EXACT [] +xref: DOID:0060496 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 ! respiratory system disorder +is_a: MONDO:0005271 {source="DOID:0060496", source="MONDO:Redundant"} ! allergic disease +intersection_of: MONDO:0005087 ! respiratory system disorder +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +property_value: exactMatch DOID:0060496 + +[Term] +id: MONDO:0000774 +name: autoimmune neuropathy +def: "An autoimmune form of peripheral neuropathy." [MONDO:patterns/autoimmune] +comment: Editor note: We do not draw a distinction between between neuropathy and peripheral neuropathy see https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/20 +synonym: "autoimmune peripheral neuropathy" EXACT [DOID:0040087] +xref: DOID:0040087 {source="MONDO:equivalentTo"} +xref: DOID:0060499 {source="MONDO:equivalentTo"} +is_a: MONDO:0000590 ! autoimmune disorder of peripheral nervous system +is_a: MONDO:0005244 ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040087 +property_value: exactMatch DOID:0060499 +property_value: excluded_subClassOf MONDO:0000568 {source="DOID:0060499"} +property_value: excluded_subClassOf MONDO:0000590 {source="DOID:0040087"} + +[Term] +id: MONDO:0000775 +name: drug allergy +def: "Immunologically mediated adverse reactions to medicinal substances used legally or illegally." [MESH:D004342] +synonym: "allergy of exposure to drug" EXACT [MONDO:patterns/allergy] +synonym: "exposure to drug allergic disease" EXACT [] +xref: DOID:0060500 {source="MONDO:equivalentTo"} +xref: MESH:D004342 {source="MONDO:equivalentTo"} +is_a: MONDO:0005271 {source="DOID:0060500", source="MESH:D004342", source="MONDO:Entailed", source="MONDO:Redundant"} ! allergic disease +intersection_of: MONDO:0005271 ! allergic disease +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch DOID:0060500 +property_value: exactMatch http://identifiers.org/mesh/D004342 + +[Term] +id: MONDO:0000777 +name: gastrointestinal allergy +def: "A allergic disease that involves the digestive tract." [MONDO:patterns/location] +synonym: "allergic disease of digestive tract" EXACT [MONDO:design_pattern] +synonym: "digestive tract allergic disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0060502 {source="MONDO:equivalentTo"} +is_a: MONDO:0005271 {source="DOID:0060502", source="MONDO:Entailed", source="MONDO:Redundant"} ! allergic disease +intersection_of: MONDO:0005271 ! allergic disease +intersection_of: disease_has_location UBERON:0001555 ! digestive tract +relationship: disease_has_location UBERON:0001555 ! digestive tract +property_value: exactMatch DOID:0060502 + +[Term] +id: MONDO:0000812 +name: vertebral column disorder +def: "A disease involving the vertebral column." [MONDO:patterns/location_top] +synonym: "disease of spine" EXACT [] +synonym: "disease of vertebral column" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vertebral column" EXACT [] +synonym: "disorder of vertebral column" EXACT [MONDO:patterns/location_top] +synonym: "spinal disease" RELATED [DOID:0060564] +synonym: "vertebral column disease" EXACT [MONDO:patterns/location] +synonym: "vertebral column disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0060564 {source="MONDO:equivalentTo"} +xref: ICD9:724.9 +xref: MESH:D013122 {source="MONDO:equivalentTo"} +xref: SCTID:699699005 {source="MONDO:equivalentTo"} +xref: UMLS:C0037933 {source="MONDO:equivalentTo"} +is_a: MONDO:0005172 ! skeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001130 ! vertebral column +relationship: disease_has_location UBERON:0001130 ! vertebral column +property_value: exactMatch DOID:0060564 +property_value: exactMatch http://identifiers.org/mesh/D013122 +property_value: exactMatch http://identifiers.org/snomedct/699699005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037933 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000833 +name: bone remodeling disease +def: "A bone disease that results in formation or resorption abnormalities located in bone." [DOID:0080005, http://en.wikipedia.org/wiki/Bone_remodeling] +xref: DOID:0080005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005381 ! bone disorder +intersection_of: MONDO:0005381 ! bone disorder +intersection_of: disease_disrupts GO:0046849 ! bone remodeling +relationship: disease_disrupts GO:0046849 ! bone remodeling +property_value: exactMatch DOID:0080005 + +[Term] +id: MONDO:0000837 +name: bone resorption disease +def: "A disease that has its basis in the disruption of bone resorption. Bone resorption is a process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [] +xref: DOID:0080011 {source="MONDO:equivalentTo"} +xref: MESH:D001862 {source="DOID:0080011", source="MONDO:equivalentTo"} +is_a: MONDO:0000833 ! bone remodeling disease +intersection_of: MONDO:0000833 ! bone remodeling disease +intersection_of: disease_disrupts GO:0045453 ! bone resorption +relationship: disease_disrupts GO:0045453 ! bone resorption +property_value: exactMatch DOID:0080011 +property_value: exactMatch http://identifiers.org/mesh/D001862 + +[Term] +id: MONDO:0000888 +name: gastrointestinal mucositis +def: "Inflammation of the mucous membranes lining the gastrointestinal tract." [NCIT:C3853] +synonym: "gastrointestinal system mucosa inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "gastrointestinal system mucosaitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of gastrointestinal system mucosa" EXACT [] +synonym: "mucositis" RELATED [DOID:0080178] +xref: DOID:0080178 {source="MONDO:equivalentTo"} +xref: ICD9:538 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:558.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D052016 {source="DOID:0080178", source="MONDO:equivalentTo"} +xref: NCIT:C3853 {source="MONDO:equivalentTo"} +xref: SCTID:95518006 {source="MONDO:equivalentTo"} +xref: UMLS:C0521585 {source="MONDO:equivalentTo", source="NCIT:C3853"} +is_a: MONDO:0004335 {source="DOID:0080178", source="MESH:D052016/inferred", source="MONDO:Redundant"} ! digestive system disorder +is_a: MONDO:0020579 ! mucositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0004786 ! gastrointestinal system mucosa +relationship: disease_has_inflammation_site UBERON:0004786 ! gastrointestinal system mucosa +property_value: exactMatch DOID:0080178 +property_value: exactMatch http://identifiers.org/mesh/D052016 +property_value: exactMatch http://identifiers.org/snomedct/95518006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0521585 +property_value: exactMatch NCIT:C3853 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000916 +name: intestinal infectious disease +def: "An infectious disease involving a pathogenic inflammatory response in the intestinal mucosa." [MONDO:patterns/specific_inflammatory_disease_by_site] +synonym: "bacterial enteritis" EXACT [DOID:100] +xref: DOID:100 {source="MONDO:equivalentTo"} +xref: ICD10CM:A00-A09 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="DOID:100", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:001-009.99 {source="DOID:100"} +xref: ICD9:008.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:266071000 {source="MONDO:equivalentTo", source="DOID:100"} +xref: UMLS:C0152516 {source="MONDO:equivalentTo"} +xref: UMLS:C0178238 {source="MONDO:equivalentTo", source="DOID:100"} +is_a: MONDO:0000888 ! gastrointestinal mucositis +is_a: MONDO:0002269 ! gastroenteritis +is_a: MONDO:0043424 ! digestive system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001242 ! intestinal mucosa +relationship: disease_has_inflammation_site UBERON:0001242 ! intestinal mucosa +property_value: exactMatch DOID:100 +property_value: exactMatch http://identifiers.org/snomedct/266071000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152516 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0178238 +property_value: exactMatch https://icd.codes/icd10cm/A00-A09 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000918 +name: endometritis +def: "An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding." [NCIT:P378] +synonym: "endometrium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of endometrium" EXACT [] +synonym: "uterine infection" EXACT [NCIT:C26764] +xref: DOID:1002 {source="MONDO:equivalentTo"} +xref: EFO:1001312 {source="MONDO:equivalentTo"} +xref: MESH:D004716 {source="DOID:1002", source="MONDO:equivalentTo"} +xref: NCIT:C26764 {source="DOID:1002", source="MONDO:equivalentTo"} +xref: SCTID:78623009 {source="DOID:1002", source="MONDO:equivalentTo"} +xref: UMLS:C0014179 {source="DOID:1002", source="MONDO:equivalentTo", source="NCIT:C26764"} +is_a: MONDO:0000931 {source="DOID:1002", source="MONDO:Redundant", source="NCIT:C26764"} ! endometrial disorder +is_a: MONDO:0020579 ! mucositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001295 ! endometrium +relationship: disease_has_inflammation_site UBERON:0001295 ! endometrium +property_value: exactMatch DOID:1002 +property_value: exactMatch http://identifiers.org/mesh/D004716 +property_value: exactMatch http://identifiers.org/snomedct/78623009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014179 +property_value: exactMatch NCIT:C26764 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000919 +name: ampulla of vater cancer +def: "A primary or metastatic malignant neoplasm involving the ampulla of Vater." [NCIT:C3536] +synonym: "cancer of hepatopancreatic ampulla" EXACT [MONDO:patterns/cancer] +synonym: "hepatopancreatic ampulla cancer" EXACT [MONDO:patterns/location] +synonym: "malignant ampulla of Vater neoplasm" EXACT [NCIT:C3536] +synonym: "malignant ampulla of Vater tumor" EXACT [NCIT:C3536] +synonym: "malignant hepatopancreatic ampulla neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of ampulla of Vater" EXACT [NCIT:C3536] +synonym: "malignant neoplasm of hepatopancreatic ampulla" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the ampulla of Vater" EXACT [NCIT:C3536] +synonym: "malignant tumor of ampulla of Vater" EXACT [NCIT:C3536] +synonym: "malignant tumor of the ampulla of Vater" EXACT [NCIT:C3536] +synonym: "malignant tumour of ampulla of vater" EXACT [DOID:10020] +xref: DOID:10020 {source="MONDO:equivalentTo"} +xref: ICD9:156.2 {source="DOID:10020"} +xref: NCIT:C3536 {source="MONDO:equivalentTo", source="DOID:10020"} +xref: SCTID:363417006 {source="MONDO:equivalentTo", source="DOID:10020"} +xref: UMLS:C0153454 {source="MONDO:equivalentTo", source="DOID:10020", source="NCIT:C3536"} +is_a: MONDO:0000920 {source="DOID:10020", source="MONDO:Redundant"} ! duodenum cancer +is_a: MONDO:0000921 {source="MONDO:Redundant", source="NCIT:C3536"} ! ampulla of vater neoplasm +is_a: MONDO:0021321 ! malignant tumor of extrahepatic bile duct +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +property_value: exactMatch DOID:10020 +property_value: exactMatch http://identifiers.org/snomedct/363417006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153454 +property_value: exactMatch NCIT:C3536 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000920 +name: duodenum cancer +def: "A primary or metastatic malignant neoplasm that affects the duodenum. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C9328] +synonym: "cancer of duodenum" EXACT [DOID:10021, MONDO:patterns/cancer, NCIT:C4803] +synonym: "duodenal cancer" EXACT [DOID:10021] +synonym: "duodenum cancer" EXACT [MONDO:patterns/location] +synonym: "malignant duodenal neoplasm" EXACT [NCIT:C9328] +synonym: "malignant duodenal tumor" EXACT [NCIT:C9328] +synonym: "malignant duodenum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of duodenum" EXACT [MONDO:patterns/cancer, NCIT:C9328] +synonym: "malignant neoplasm of the duodenum" EXACT [NCIT:C9328] +synonym: "malignant tumor of duodenum" EXACT [NCIT:C9328] +synonym: "malignant tumor of the duodenum" EXACT [NCIT:C9328] +xref: DOID:10021 {source="MONDO:equivalentTo"} +xref: ICD9:152.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10021"} +xref: MESH:D004379 {source="MONDO:equivalentTo", source="DOID:10021"} +xref: NCIT:C9328 {source="MONDO:equivalentTo", source="DOID:10021"} +xref: SCTID:363403002 {source="MONDO:equivalentTo", source="DOID:10021"} +is_a: MONDO:0000956 {source="DOID:10021", source="MONDO:Redundant", source="NCIT:C9328"} ! small intestine cancer +is_a: MONDO:0021375 {source="MONDO:Redundant", source="NCIT:C9328"} ! tumor of duodenum +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: exactMatch DOID:10021 +property_value: exactMatch http://identifiers.org/mesh/D004379 +property_value: exactMatch http://identifiers.org/snomedct/363403002 +property_value: exactMatch NCIT:C9328 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000921 +name: ampulla of vater neoplasm +def: "A benign or malignant neoplasm involving the ampulla of Vater." [NCIT:C4443] +synonym: "ampulla of Vater tumor" EXACT [NCIT:C4443] +synonym: "AMPULLAOFVATER" RELATED ABBREVIATION [ONCOTREE:AMPULLAOFVATER] +synonym: "hepatopancreatic ampulla neoplasm" EXACT [] +synonym: "hepatopancreatic ampulla neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "hepatopancreatic ampulla tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of ampulla of Vater" EXACT [NCIT:C4443] +synonym: "neoplasm of hepatopancreatic ampulla" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the ampulla of Vater" EXACT [NCIT:C4443] +synonym: "tumor of ampulla of Vater" EXACT [NCIT:C4443] +synonym: "tumor of hepatopancreatic ampulla" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the ampulla of Vater" EXACT [DOID:10022, NCIT:C4443] +xref: DOID:10022 {source="MONDO:equivalentTo"} +xref: NCIT:C4443 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:10022"} +xref: ONCOTREE:AMPULLAOFVATER {source="MONDO:equivalentTo"} +xref: SCTID:126858004 {source="MONDO:equivalentTo", source="DOID:10022"} +xref: UMLS:C0345916 {source="MONDO:equivalentTo", source="NCIT:C4443", source="DOID:10022"} +is_a: MONDO:0006709 ! common bile duct neoplasm +is_a: MONDO:0021375 {source="MONDO:Redundant"} ! tumor of duodenum +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +relationship: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +property_value: exactMatch DOID:10022 +property_value: exactMatch http://identifiers.org/snomedct/126858004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345916 +property_value: exactMatch NCIT:C4443 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0000922 +name: pelvic inflammatory disease +def: "Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection." [NCIT:C3889] +synonym: "disease (PID), pelvic inflammatory" RELATED [NCIT:C3889] +synonym: "inflammatory disease (PID), pelvic" RELATED [NCIT:C3889] +synonym: "pelvic infection" RELATED [NCIT:C3889] +synonym: "pelvic inflammatory disease" EXACT [NCIT:C3889] +synonym: "pelvic inflammatory disease, (PID)" RELATED [NCIT:C3889] +synonym: "PID" EXACT ABBREVIATION [DOID:1003] +synonym: "PID, pelvic inflammatory disease" RELATED [NCIT:C3889] +xref: DOID:1003 {source="MONDO:equivalentTo"} +xref: EFO:1001388 {source="MONDO:equivalentTo"} +xref: ICD10CM:N70-N77 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="DOID:1003", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:614-616.99 {source="DOID:1003"} +xref: ICD9:614.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:614.9 {source="DOID:1003", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D000292 {source="DOID:1003", source="MONDO:equivalentTo"} +xref: NCIT:C3889 {source="DOID:1003", source="MONDO:equivalentTo"} +xref: SCTID:198130006 {source="DOID:1003", source="MONDO:equivalentTo"} +xref: UMLS:C0242172 {source="DOID:1003", source="MONDO:equivalentTo", source="NCIT:C3889"} +is_a: MONDO:0002263 {source="DOID:1003", source="MESH:D000292/inferred", source="MONDO:Redundant", source="NCIT:C3889/inferred"} ! female reproductive system disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000474 ! female reproductive system +intersection_of: disease_has_inflammation_site UBERON:0002355 ! pelvic region of trunk +relationship: disease_has_inflammation_site UBERON:0000474 ! female reproductive system +relationship: disease_has_inflammation_site UBERON:0002355 ! pelvic region of trunk +property_value: exactMatch DOID:1003 +property_value: exactMatch http://identifiers.org/mesh/D000292 +property_value: exactMatch http://identifiers.org/snomedct/198130006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0242172 +property_value: exactMatch https://icd.codes/icd10cm/N70-N77 +property_value: exactMatch NCIT:C3889 + +[Term] +id: MONDO:0000931 +name: endometrial disorder +def: "A non-neoplastic or neoplastic disorder that affects the endometrium. Representative examples include endometritis, endometrial hyperplasia, and endometrial carcinoma." [NCIT:P378] +synonym: "disease of endometrium" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of endometrium" EXACT [] +synonym: "disorder of endometrium" EXACT [MONDO:patterns/location_top] +synonym: "endometrial disorder" EXACT [] +synonym: "endometrium disease" EXACT [MONDO:patterns/location] +synonym: "endometrium disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1005 {source="MONDO:equivalentTo"} +xref: NCIT:C3504 {source="DOID:1005", source="MONDO:equivalentTo"} +xref: SCTID:418632009 {source="DOID:1005", source="MONDO:equivalentTo"} +is_a: MONDO:0002654 {source="DOID:1005", source="MONDO:Redundant", source="NCIT:C3504"} ! uterine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001295 ! endometrium +relationship: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch DOID:1005 +property_value: exactMatch http://identifiers.org/snomedct/418632009 +property_value: exactMatch NCIT:C3504 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000941 +name: eyelid degenerative disorder +def: "A neurodegenerative disease that involves the eyelid." [MONDO:patterns/location] +synonym: "eyelid neurodegenerative disease" EXACT [MONDO:patterns/location] +synonym: "neurodegenerative disease of eyelid" EXACT [MONDO:design_pattern] +xref: DOID:10120 {source="MONDO:equivalentObsolete"} +xref: ICD9:374.50 {source="DOID:10120"} +xref: SCTID:1112003 {source="MONDO:equivalentTo", source="DOID:10120"} +xref: UMLS:C0155209 {source="MONDO:equivalentTo", source="DOID:10120"} +is_a: MONDO:0003382 {source="DOID:10120", source="MONDO:Redundant"} ! eyelid disorder +is_a: MONDO:0004884 ! eye degenerative disorder +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch http://identifiers.org/snomedct/1112003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155209 + +[Term] +id: MONDO:0000942 +name: corneal disorder +def: "A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma." [NCIT:P378] +synonym: "cornea disease" EXACT [MONDO:patterns/location] +synonym: "cornea disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "corneal disease" EXACT [NCIT:C26731] +synonym: "corneal disorder" EXACT [NCIT:C26731] +synonym: "disease of cornea" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cornea" EXACT [] +synonym: "disorder of cornea" EXACT [MONDO:patterns/location_top] +xref: DOID:10124 {source="MONDO:equivalentTo"} +xref: ICD9:371.30 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:371.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:371.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10124"} +xref: MESH:D003316 {source="MONDO:equivalentTo", source="DOID:10124"} +xref: NCIT:C26731 {source="MONDO:equivalentTo", source="DOID:10124"} +xref: SCTID:15250008 {source="MONDO:equivalentTo", source="DOID:10124"} +xref: UMLS:C0010034 {source="MONDO:equivalentTo", source="NCIT:C26731", source="DOID:10124"} +is_a: MONDO:0002051 ! integumentary system disorder +is_a: MONDO:0005328 {source="DOID:10124", source="MESH:D003316", source="MONDO:Redundant", source="NCIT:C26731"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000964 ! cornea +relationship: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch DOID:10124 +property_value: exactMatch http://identifiers.org/mesh/D003316 +property_value: exactMatch http://identifiers.org/snomedct/15250008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010034 +property_value: exactMatch NCIT:C26731 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0000951 +name: thymus lymphoma +def: "A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma." [NCIT:C6451] +synonym: "lymphoma of the Thymus" EXACT [NCIT:C6451] +synonym: "lymphoma of Thymus" EXACT [NCIT:C6451] +synonym: "lymphoma of thymus" EXACT [] +synonym: "primary thymic lymphoma" EXACT [NCIT:C6451] +synonym: "thymic lymphoma" EXACT [MONDO:0006057, NCIT:C6451] +synonym: "Thymus lymphoma" EXACT [NCIT:C6451] +synonym: "thymus lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:10146 {source="MONDO:equivalentTo"} +xref: EFO:1000054 {source="MONDO:equivalentTo"} +xref: NCIT:C6451 {source="EFO:1000054", source="MONDO:equivalentTo", source="DOID:10146"} +xref: UMLS:C1336745 {source="EFO:1000054", source="NCIT:C6451", source="MONDO:equivalentTo", source="DOID:10146"} +is_a: MONDO:0002586 {source="DOID:10146", source="MONDO:Redundant", source="NCIT:C6451"} ! thymus cancer +is_a: MONDO:0004021 {source="NCIT:C6451"} ! mediastinal malignant lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch DOID:10146 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336745 +property_value: exactMatch NCIT:C6451 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0000952 +name: cancer of long bone of lower limb +def: "A cancer that involves the hindlimb long bone." [MONDO:patterns/location] +synonym: "cancer of hindlimb long bone" EXACT [MONDO:patterns/cancer] +synonym: "hindlimb long bone cancer" EXACT [MONDO:patterns/location] +synonym: "long bones of lower limb cancer" RELATED [DOID:10149] +synonym: "malignant hindlimb long bone neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of hindlimb long bone" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of long bones of leg" EXACT [DOID:10149] +xref: DOID:10149 {source="MONDO:equivalentTo"} +xref: ICD10CM:C40.2 {source="DOID:10149", source="MONDO:equivalentTo"} +xref: ICD9:170.7 {source="DOID:10149", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:449627008 {source="MONDO:equivalentTo"} +xref: UMLS:C3265932 {source="MONDO:equivalentTo"} +is_a: MONDO:0024311 ! cancer affecting bone of limb skeleton +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003608 ! hindlimb long bone +relationship: disease_has_location UBERON:0003608 ! hindlimb long bone +property_value: exactMatch DOID:10149 +property_value: exactMatch http://identifiers.org/snomedct/449627008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3265932 +property_value: exactMatch https://icd.codes/icd10cm/C40.2 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000953 +name: cancer of short bone of lower limb +synonym: "malignant neoplasm of short bone of lower limb" EXACT [DOID:10151] +synonym: "malignant neoplasm of short bones of leg" EXACT [DOID:10151] +xref: DOID:10151 {source="MONDO:equivalentTo"} +xref: ICD10CM:C40.3 {source="MONDO:equivalentTo", source="DOID:10151"} +xref: ICD9:170.8 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10151"} +xref: SCTID:712525007 {source="MONDO:equivalentTo", source="DOID:10151"} +xref: UMLS:C0153518 {source="MONDO:equivalentTo", source="DOID:10151"} +is_a: MONDO:0002129 ! bone cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002103 ! hindlimb +intersection_of: disease_has_location UBERON:0013630 ! short bone +relationship: disease_has_location UBERON:0002103 ! hindlimb +relationship: disease_has_location UBERON:0013630 ! short bone +property_value: exactMatch DOID:10151 +property_value: exactMatch http://identifiers.org/snomedct/712525007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153518 +property_value: exactMatch https://icd.codes/icd10cm/C40.3 +property_value: excluded_subClassOf MONDO:0000952 {source="DOID:10151"} + +[Term] +id: MONDO:0000955 +name: ileum cancer +def: "A malignant neoplasm involving the ileum" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of ileum" EXACT [MONDO:patterns/cancer] +synonym: "ileum cancer" EXACT [MONDO:patterns/location] +synonym: "malignant ileum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of ileum" EXACT [DOID:10153, ICD9CM:152.2, MONDO:patterns/cancer] +xref: DOID:10153 {source="MONDO:equivalentTo"} +xref: ICD9:152.2 {source="DOID:10153"} +is_a: MONDO:0000956 {source="DOID:10153", source="MONDO:Entailed", source="MONDO:Redundant"} ! small intestine cancer +is_a: MONDO:0006801 ! ileal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002116 ! ileum +property_value: exactMatch DOID:10153 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0000956 +name: small intestine cancer +def: "A primary or metastatic malignant neoplasm involving the small intestine." [NCIT:C7523] +subset: gard_rare {source="GARD:0009385"} +synonym: "cancer of small intestine" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of small bowel" EXACT [NCIT:C7523] +synonym: "malignant neoplasm of small intestine" EXACT [MONDO:patterns/cancer, NCIT:C7523] +synonym: "malignant neoplasm of the small bowel" EXACT [NCIT:C7523] +synonym: "malignant neoplasm of the small intestine" EXACT [NCIT:C7523] +synonym: "malignant neoplasms of the small intestine" RELATED [GARD:0009385] +synonym: "malignant small bowel neoplasm" EXACT [NCIT:C7523] +synonym: "malignant small bowel tumor" EXACT [NCIT:C7523] +synonym: "malignant small intestinal neoplasm" EXACT [NCIT:C7523] +synonym: "malignant small intestine neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7523] +synonym: "malignant small intestine tumor" EXACT [NCIT:C7523] +synonym: "malignant tumor of small bowel" EXACT [NCIT:C7523] +synonym: "malignant tumor of small intestine" EXACT [NCIT:C7523] +synonym: "malignant tumor of the small bowel" EXACT [NCIT:C7523] +synonym: "malignant tumor of the small intestine" EXACT [NCIT:C7523] +synonym: "small bowel tumors" RELATED [GARD:0009385] +synonym: "small intestine cancer" EXACT [MONDO:patterns/location] +xref: DOID:10154 {source="MONDO:equivalentTo"} +xref: GARD:0009385 {source="MONDO:equivalentTo"} +xref: ICD9:152.9 {source="DOID:10154"} +xref: NCIT:C7523 {source="MONDO:equivalentTo", source="DOID:10154"} +xref: UMLS:C0153425 {source="MONDO:equivalentTo", source="NCIT:C7523", source="DOID:10154"} +is_a: MONDO:0004251 {source="MONDO:Redundant", source="NCIT:C7523"} ! small intestine neoplasm +is_a: MONDO:0005814 {source="DOID:10154", source="MONDO:Redundant", source="NCIT:C7523"} ! intestinal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:10154 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153425 +property_value: exactMatch NCIT:C7523 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9385/small-intestine-cancer xsd:anyURI {source="GARD:0009385"} + +[Term] +id: MONDO:0000958 +name: neuroretinitis +def: "Neuroretinitis is an inflammation of the neural retina and optic nerve. Pathology: Direct invasion or autoimmune activation against the optic nerve may cause optic nerve vascular inflammation with secondary inflammation and edema in the nerve fiber layer of the retina." [http://eyewiki.aao.org/Neuroretinitis] +synonym: "focal retinitis and retinochoroiditis, juxtapapillary" NARROW [DOID:10176, ICD9CM:363.05] +synonym: "Juxtapapillary focal retinitis and retinochoroiditis" NARROW [DOID:10176] +synonym: "papilloretinitis" NARROW [DOID:10176] +xref: DOID:10176 {source="MONDO:equivalentTo"} +xref: ICD9:363.05 {source="http://eyewiki.aao.org/Neuroretinitis"} +xref: UMLS:C0154874 {source="MONDO:equivalentTo", source="DOID:10176"} +is_a: MONDO:0002122 ! neuritis +is_a: MONDO:0003579 ! retinal nerve fibre layer disorder +is_a: MONDO:0006879 ! optic papillitis +intersection_of: MONDO:0002122 ! neuritis +intersection_of: disease_has_inflammation_site UBERON:0000941 ! cranial nerve II +intersection_of: disease_has_inflammation_site UBERON:0001793 ! nerve fiber layer of retina +relationship: disease_has_inflammation_site UBERON:0001793 ! nerve fiber layer of retina +property_value: exactMatch DOID:10176 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154874 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0000980 +name: aortic atherosclerosis +def: "A atherosclerosis that involves the aorta." [MONDO:patterns/location] +synonym: "aorta atherosclerosis" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "aortic atherosclerosis" EXACT [DOID:10230, MONDO:ambiguous] +synonym: "aortic atherosclerosis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "atherosclerosis of aorta" EXACT [DOID:10230] +xref: DOID:10230 {source="MONDO:equivalentTo"} +xref: HP:0012397 {source="MONDO:otherHierarchy"} +xref: ICD9:440.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10230"} +xref: SCTID:81817003 {source="MONDO:equivalentTo", source="DOID:10230"} +xref: UMLS:C0155733 {source="MONDO:equivalentTo", source="DOID:10230"} +is_a: MONDO:0005311 {source="DOID:10230", source="MONDO:Redundant"} ! atherosclerosis +is_a: MONDO:0005561 {source="MONDO:Redundant"} ! aortic disorder +intersection_of: MONDO:0005311 ! atherosclerosis +intersection_of: disease_has_location UBERON:0000947 ! aorta +property_value: exactMatch DOID:10230 +property_value: exactMatch http://identifiers.org/snomedct/81817003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155733 +property_value: IAO:0000589 "aortic atherosclerosis (disease)" xsd:string + +[Term] +id: MONDO:0000986 +name: pleurisy +def: "Inflammation of the pleura. It is usually caused by infections. Chest pain while breathing or coughing is the presenting symptom." [NCIT:C26860] +synonym: "inflammation of pleura" EXACT [] +synonym: "pleura inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "pleuritis" EXACT [NCIT:C26860] +xref: DOID:10247 {source="MONDO:equivalentTo"} +xref: EFO:1001825 {source="MONDO:equivalentTo"} +xref: ICD10CM:R09.1 {source="MONDO:equivalentTo"} +xref: ICD9:511.8 {source="DOID:10247"} +xref: MESH:D010998 {source="MONDO:equivalentTo"} +xref: NCIT:C26860 {source="MONDO:equivalentTo"} +xref: SCTID:196075003 {source="MONDO:equivalentTo"} +xref: UMLS:C0032231 {source="NCIT:C26860", source="MONDO:equivalentTo"} +is_a: MONDO:0002037 {source="DOID:10247", source="MESH:D010998", source="MONDO:Redundant", source="NCIT:C26860"} ! pleural disorder +is_a: MONDO:0043786 ! serositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000977 ! pleura +relationship: disease_has_feature HP:0001370 ! Rheumatoid arthritis +relationship: disease_has_feature HP:0001733 ! Pancreatitis +relationship: disease_has_feature HP:0002090 ! Pneumonia +relationship: disease_has_feature HP:0002102 ! Pleuritis +relationship: disease_has_feature HP:0002204 ! Pulmonary embolism +relationship: disease_has_feature HP:0002725 ! Systemic lupus erythematosus +relationship: disease_has_inflammation_site UBERON:0000977 ! pleura +property_value: exactMatch DOID:10247 +property_value: exactMatch http://identifiers.org/mesh/D010998 +property_value: exactMatch http://identifiers.org/snomedct/196075003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0032231 +property_value: exactMatch https://icd.codes/icd10cm/R09.1 +property_value: exactMatch NCIT:C26860 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0000987 +name: cholesterolosis of gallbladder +def: "A disorder characterized by a change in the gallbladder wall due to excess cholesterol." [Wikipedia:Cholesterolosis_of_gallbladder] +synonym: "strawberry gallbladder" EXACT [DOID:10254, ICD9CM:575.6] +xref: DOID:10254 {source="MONDO:equivalentTo"} +xref: ICD10CM:K82.4 {source="MONDO:equivalentTo", source="DOID:10254"} +xref: ICD9:575.6 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10254"} +xref: SCTID:61565001 {source="MONDO:equivalentTo", source="DOID:10254"} +xref: UMLS:C0152456 {source="MONDO:equivalentTo", source="DOID:10254"} +is_a: MONDO:0005281 {source="DOID:10254", source="MONDO:Redundant"} ! gallbladder disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0042632 ! cholesterol homeostasis +intersection_of: disease_has_location UBERON:0004781 ! gall bladder lamina propria +relationship: disease_has_basis_in_disruption_of GO:0042632 ! cholesterol homeostasis +relationship: disease_has_location UBERON:0004781 ! gall bladder lamina propria +property_value: exactMatch DOID:10254 +property_value: exactMatch http://identifiers.org/snomedct/61565001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152456 +property_value: exactMatch https://icd.codes/icd10cm/K82.4 + +[Term] +id: MONDO:0000992 +name: heart conduction disease +def: "A disease that has its basis in the disruption of the heart's electrical conduction system." [https://orcid.org/0000-0002-6601-2165, MONDO:cjm] +synonym: "cardiac conduction disease" EXACT [] +synonym: "cardiac conduction disorder" EXACT [] +synonym: "conduction disease of heart" EXACT [] +synonym: "disease of cardiac conduction" EXACT [] +synonym: "disorder of cardiac conduction" EXACT [] +synonym: "heart rhythm disease" EXACT [DOID:10273] +xref: DOID:10273 {source="MONDO:equivalentTo"} +xref: ICD9:426.6 {source="DOID:10273"} +xref: SCTID:44808001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 {source="DOID:10273", source="MONDO:Entailed", source="MONDO:Redundant"} ! heart disorder +intersection_of: MONDO:0005267 ! heart disorder +intersection_of: disease_disrupts GO:0061337 ! cardiac conduction +relationship: disease_disrupts GO:0061337 ! cardiac conduction +property_value: exactMatch DOID:10273 +property_value: exactMatch http://identifiers.org/snomedct/44808001 + +[Term] +id: MONDO:0000993 +name: prostate squamous cell carcinoma +def: "An invasive prostate carcinoma characterized by the presence of squamous differentiation of the malignant cellular infiltrate. There is no evidence of glandular differentiation." [NCIT:C5536] +synonym: "prostate gland squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "prostate squamous cell carcinoma" EXACT [NCIT:C5536] +synonym: "PRSC" RELATED ABBREVIATION [ONCOTREE:PRSC] +synonym: "squamous cell carcinoma of prostate" EXACT [DOID:10287, NCIT:C5536] +synonym: "squamous cell carcinoma of the prostate" EXACT [DOID:10287, NCIT:C5536] +xref: DOID:10287 {source="MONDO:equivalentTo"} +xref: NCIT:C5536 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:10287"} +xref: ONCOTREE:PRSC {source="MONDO:equivalentTo"} +xref: SCTID:399590005 {source="MONDO:equivalentTo", source="DOID:10287"} +xref: UMLS:C1302530 {source="MONDO:equivalentTo", source="NCIT:C5536", source="DOID:10287"} +is_a: MONDO:0005096 {source="DOID:10287", source="MONDO:Redundant", source="NCIT:C5536"} ! squamous cell carcinoma +is_a: MONDO:0005159 {source="DOID:10287", source="MONDO:Redundant", source="NCIT:C5536/inferred"} ! prostate carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:10287 +property_value: exactMatch http://identifiers.org/snomedct/399590005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1302530 +property_value: exactMatch NCIT:C5536 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0000996 +name: prostate lymphoma +def: "A rare non-Hodgkin or Hodgkin lymphoma that arises from the prostate gland." [NCIT:C5533] +synonym: "lymphoma of prostate" EXACT [DOID:10290, NCIT:C5533] +synonym: "lymphoma of prostate gland" EXACT [MONDO:design_pattern] +synonym: "lymphoma of the prostate" EXACT [DOID:10290, NCIT:C5533] +synonym: "primary prostate lymphoma" EXACT [NCIT:C5533] +synonym: "prostate gland lymphoma" EXACT [MONDO:patterns/location] +synonym: "prostate lymphoma" EXACT [NCIT:C5533] +xref: DOID:10290 {source="MONDO:equivalentTo"} +xref: NCIT:C5533 {source="DOID:10290", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1335512 {source="DOID:10290", source="MONDO:equivalentTo", source="NCIT:C5533"} +is_a: MONDO:0005062 {source="DOID:10290", source="MONDO:Redundant", source="NCIT:C5533/inferred"} ! lymphoma +is_a: MONDO:0008315 {source="DOID:10290", source="NCIT:C5533"} ! prostate cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:10290 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335512 +property_value: exactMatch NCIT:C5533 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001007 +name: chronic meningitis +def: "Chronic form of meningitis (disease)." [MONDO:patterns/chronic] +synonym: "chronic meningitis (disease)" EXACT [] +synonym: "meningitis (disease), chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:10341 {source="MONDO:equivalentTo"} +xref: ICD10CM:G03.1 {source="MONDO:equivalentTo", source="DOID:10341"} +xref: ICD9:322.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10341"} +xref: SCTID:21664006 {source="MONDO:equivalentTo", source="DOID:10341"} +xref: UMLS:C0154653 {source="MONDO:equivalentTo", source="DOID:10341"} +is_a: MONDO:0021108 ! meningitis +intersection_of: MONDO:0021108 ! meningitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:10341 +property_value: exactMatch http://identifiers.org/snomedct/21664006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154653 +property_value: exactMatch https://icd.codes/icd10cm/G03.1 +property_value: excluded_subClassOf MONDO:0004796 {source="DOID:10341"} + +[Term] +id: MONDO:0001016 +name: epididymis cancer +def: "A primary or metastatic malignant neoplasm that affects the epididymis. Representative examples include primary epididymal adenocarcinoma and metastatic carcinoma to the epididymis arising from another anatomic site." [NCIT:C3558] +synonym: "cancer of epididymis" EXACT [MONDO:patterns/cancer] +synonym: "epididymis cancer" EXACT [MONDO:patterns/location] +synonym: "malignant epididymal neoplasm" EXACT [NCIT:C3558] +synonym: "malignant epididymal tumor" EXACT [DOID:10366, NCIT:C3558] +synonym: "malignant epididymis neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of epididymis" EXACT [DOID:10366, ICD9CM:187.5, MONDO:patterns/cancer, NCIT:C3558] +synonym: "malignant neoplasm of the epididymis" EXACT [NCIT:C3558] +synonym: "malignant tumor of epididymis" EXACT [NCIT:C3558] +synonym: "malignant tumor of the epididymis" EXACT [NCIT:C3558] +xref: DOID:10366 {source="MONDO:equivalentTo"} +xref: ICD9:187.5 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10366"} +xref: NCIT:C3558 {source="MONDO:equivalentTo", source="DOID:10366"} +xref: SCTID:363452003 {source="MONDO:equivalentTo", source="DOID:10366"} +xref: UMLS:C0153602 {source="MONDO:equivalentTo", source="NCIT:C3558", source="DOID:10366"} +is_a: MONDO:0003283 {source="MONDO:Redundant", source="NCIT:C3558"} ! epididymal neoplasm +is_a: MONDO:0005836 {source="DOID:10366", source="MONDO:Redundant", source="NCIT:C3558"} ! male reproductive organ cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001301 ! epididymis +property_value: exactMatch DOID:10366 +property_value: exactMatch http://identifiers.org/snomedct/363452003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153602 +property_value: exactMatch NCIT:C3558 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001017 +name: epididymal adenocarcinoma +def: "A rare adenocarcinoma that arises from the epididymis. It usually presents as a scrotal mass and may be associated with testicular pain." [NCIT:C39957] +synonym: "adenocarcinoma of the epididymis" EXACT [DOID:10368, NCIT:C39957] +synonym: "epididymal adenocarcinoma" EXACT [NCIT:C39957] +synonym: "epididymis adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:10368 {source="MONDO:equivalentTo"} +xref: NCIT:C39957 {source="DOID:10368", source="MONDO:equivalentTo"} +xref: UMLS:C1510784 {source="DOID:10368", source="MONDO:equivalentTo", source="NCIT:C39957"} +is_a: MONDO:0001016 {source="DOID:10368", source="MONDO:Redundant", source="NCIT:C39957"} ! epididymis cancer +is_a: MONDO:0004970 {source="DOID:10368", source="MONDO:Redundant", source="NCIT:C39957"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001301 ! epididymis +property_value: exactMatch DOID:10368 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1510784 +property_value: exactMatch NCIT:C39957 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0001028 +name: acute pericementitis +def: "An acute inflammatory process that affects the tissues that surround and support the teeth." [NCIT:P378] +synonym: "acute periodontitis" EXACT [DOID:10423, ICD9CM:523.3, NCIT:C34354] +synonym: "periodontitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:10423 {source="MONDO:equivalentTo"} +xref: ICD9:523.3 {source="DOID:10423"} +xref: ICD9:523.33 {source="DOID:10423"} +xref: NCIT:C34354 {source="DOID:10423", source="MONDO:equivalentTo"} +xref: SCTID:21638000 {source="DOID:10423", source="MONDO:equivalentTo"} +xref: UMLS:C0001342 {source="DOID:10423", source="MONDO:equivalentTo", source="NCIT:C34354"} +is_a: MONDO:0005076 {source="DOID:10423", source="MONDO:Redundant", source="NCIT:C34354"} ! periodontitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0005076 ! periodontitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:10423 +property_value: exactMatch http://identifiers.org/snomedct/21638000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001342 +property_value: exactMatch NCIT:C34354 + +[Term] +id: MONDO:0001039 +name: tonsillitis +def: "Inflammation of the tonsillar tissue." [NCIT:P378] +synonym: "chronic tonsillitis" EXACT [DOID:10456] +synonym: "inflammation of tonsil" EXACT [] +synonym: "throat infection - tonsillitis" EXACT [DOID:10456] +synonym: "tonsil inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "tonsilitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10456 {source="MONDO:equivalentTo"} +xref: ICD10CM:J35.01 {source="DOID:10456", source="MONDO:equivalentTo"} +xref: ICD9:474.00 {source="DOID:10456", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014069 {source="DOID:10456", source="MONDO:equivalentTo"} +xref: NCIT:C116006 {source="DOID:10456", source="MONDO:equivalentTo"} +xref: SCTID:90979004 {source="DOID:10456", source="MONDO:equivalentTo"} +xref: UMLS:C0040425 {source="DOID:10456", source="MONDO:equivalentTo", source="NCIT:C116006"} +xref: UMLS:C0149517 {source="DOID:10456", source="MONDO:equivalentTo"} +is_a: MONDO:0004867 {source="DOID:10456"} ! upper respiratory tract disorder +is_a: MONDO:0020592 ! disorder of pharynx +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0044986 ! lymphoid system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002372 ! tonsil +relationship: disease_has_feature HP:0011110 ! Recurrent tonsillitis +relationship: disease_has_inflammation_site UBERON:0002372 ! tonsil +property_value: exactMatch DOID:10456 +property_value: exactMatch http://identifiers.org/mesh/D014069 +property_value: exactMatch http://identifiers.org/snomedct/90979004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040425 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149517 +property_value: exactMatch https://icd.codes/icd10cm/J35.01 +property_value: exactMatch NCIT:C116006 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001040 +name: nasopharyngitis +def: "An inflammatory process that affects the nasopharynx." [NCIT:P378] +synonym: "chronic nasopharyngitis" EXACT [DOID:10460] +synonym: "inflammation of nasopharynx" EXACT [] +synonym: "nasopharynx inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10460 {source="MONDO:equivalentTo"} +xref: ICD9:472.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10460"} +xref: MESH:D009304 {source="MONDO:equivalentTo", source="DOID:10460"} +xref: NCIT:C34837 {source="MONDO:equivalentTo", source="DOID:10460"} +xref: SCTID:47841006 {source="MONDO:equivalentTo", source="DOID:10460"} +xref: UMLS:C0027441 {source="NCIT:C34837", source="MONDO:equivalentTo", source="DOID:10460"} +xref: UMLS:C0155826 {source="MONDO:equivalentTo", source="DOID:10460"} +is_a: MONDO:0004821 {source="DOID:10460", source="MESH:D009304", source="MONDO:Redundant", source="NCIT:C34837"} ! nasopharyngeal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001728 ! nasopharynx +relationship: disease_has_inflammation_site UBERON:0001728 ! nasopharynx +property_value: exactMatch DOID:10460 +property_value: exactMatch http://identifiers.org/mesh/D009304 +property_value: exactMatch http://identifiers.org/snomedct/47841006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027441 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155826 +property_value: exactMatch NCIT:C34837 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001042 +name: patellar tendinitis +def: "A tendinitis that involves the patella." [MONDO:patterns/location] +synonym: "patella tendinitis" EXACT [MONDO:patterns/location] +synonym: "patellar tendonitis" EXACT [DOID:10471] +synonym: "tendinitis of patella" EXACT [MONDO:design_pattern] +xref: DOID:10471 {source="MONDO:equivalentTo"} +xref: ICD10CM:M76.5 {source="MONDO:equivalentTo", source="DOID:10471"} +xref: ICD9:726.64 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10471"} +xref: SCTID:37785001 {source="MONDO:equivalentTo", source="DOID:10471"} +xref: UMLS:C0158317 {source="MONDO:equivalentTo", source="DOID:10471"} +is_a: MONDO:0004857 {source="DOID:10471", source="MONDO:Redundant"} ! tendinitis +is_a: MONDO:0005172 ! skeletal system disorder +intersection_of: MONDO:0004857 ! tendinitis +intersection_of: disease_has_location UBERON:0002446 ! patella +relationship: disease_has_location UBERON:0002446 ! patella +property_value: exactMatch DOID:10471 +property_value: exactMatch http://identifiers.org/snomedct/37785001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0158317 +property_value: exactMatch https://icd.codes/icd10cm/M76.5 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0001056 +name: gastric cancer +def: "A primary or metastatic malignant neoplasm involving the stomach." [NCIT:C9331] +synonym: "Ca body - stomach" NARROW [DOID:10534] +synonym: "ca greater curvature of stomach" NARROW [DOID:10534] +synonym: "Ca lesser curvature - stomach" EXACT [DOID:10534] +synonym: "cancer of stomach" EXACT [MONDO:patterns/cancer] +synonym: "gastric cancer" EXACT [DOID:10534] +synonym: "gastric cancer risk after h. pylori infection" EXACT [OMIM:613659, OMIM:genemap2] +synonym: "gastric cancer, intestinal" RELATED [OMIM:613659] +synonym: "gastric cancer, somatic" EXACT [OMIM:613659, OMIM:genemap2] +synonym: "gastric neoplasm" BROAD [DOID:10534, NCIT:C3387] +synonym: "malignant gastric neoplasm" EXACT [NCIT:C9331] +synonym: "malignant gastric tumor" EXACT [NCIT:C9331] +synonym: "malignant neoplasm of body of stomach" NARROW [DOID:10534] +synonym: "malignant neoplasm of lesser curve of stomach" EXACT [DOID:10534] +synonym: "malignant neoplasm of stomach" EXACT [MONDO:patterns/cancer, NCIT:C9331] +synonym: "malignant neoplasm of the stomach" EXACT [NCIT:C9331] +synonym: "malignant stomach neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of body of stomach" EXACT [DOID:10534] +synonym: "malignant tumor of greater curve of stomach" EXACT [DOID:10534] +synonym: "malignant tumor of lesser curve of stomach" EXACT [DOID:10534] +synonym: "malignant tumor of stomach" EXACT [NCIT:C9331] +synonym: "malignant tumor of the stomach" EXACT [NCIT:C9331] +synonym: "stomach cancer" EXACT [MONDO:patterns/location] +xref: DOID:10534 {source="MONDO:equivalentTo"} +xref: GARD:0007704 {source="MONDO:equivalentTo"} +xref: ICD10CM:C16 {source="DOID:10534", source="MONDO:equivalentTo"} +xref: ICD9:151 {source="DOID:10534"} +xref: ICD9:151.4 {source="DOID:10534"} +xref: ICD9:151.5 {source="DOID:10534"} +xref: ICD9:151.6 {source="DOID:10534"} +xref: ICD9:151.9 {source="DOID:10534"} +xref: NCIT:C9331 {source="DOID:10534", source="MONDO:equivalentTo"} +xref: OMIM:613659 {source="DOID:10534", source="MONDO:equivalentTo"} +is_a: MONDO:0002516 {source="DOID:10534", source="ICD10CM:C16", source="MONDO:Redundant", source="NCIT:C9331"} ! digestive system cancer +is_a: MONDO:0021085 {source="MONDO:Redundant", source="NCIT:C9331"} ! gastric neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:10534 +property_value: exactMatch https://icd.codes/icd10cm/C16 +property_value: exactMatch https://omim.org/entry/613659 +property_value: exactMatch NCIT:C9331 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0001059 +name: gastric lymphoma +def: "An extranodal lymphoma that arises from the stomach with the bulk of the mass located in the stomach. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue." [NCIT:C4636] +synonym: "gastric lymphoma" EXACT [NCIT:C4636] +synonym: "lymphoma of stomach" EXACT [NCIT:C4636] +synonym: "lymphoma of the stomach" EXACT [DOID:10540, NCIT:C4636] +synonym: "primary gastric lymphoma" EXACT [NCIT:C4636] +synonym: "stomach lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:10540 {source="MONDO:equivalentTo"} +xref: ICD9:202.83 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4636 {source="MONDO:equivalentTo", source="DOID:10540"} +xref: SCTID:276811008 {source="MONDO:equivalentTo", source="DOID:10540"} +xref: UMLS:C0349532 {source="MONDO:equivalentTo", source="DOID:10540", source="NCIT:C4636"} +is_a: MONDO:0001056 {source="DOID:10540", source="MONDO:Redundant", source="NCIT:C4636"} ! gastric cancer +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C4636"} ! gastrointestinal lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:10540 +property_value: exactMatch http://identifiers.org/snomedct/276811008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349532 +property_value: exactMatch NCIT:C4636 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001061 +name: pylorus cancer +def: "A malignant neoplasm involving the pylorus." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca pylorus - stomach" EXACT [DOID:10544] +synonym: "cancer of pylorus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of Prepylorus" EXACT [DOID:10544] +synonym: "malignant neoplasm of pylorus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pylorus of stomach" EXACT [DOID:10544] +synonym: "malignant pylorus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of pylorus" EXACT [DOID:10544] +synonym: "pylorus cancer" EXACT [MONDO:patterns/location] +xref: DOID:10544 {source="MONDO:equivalentTo"} +xref: ICD9:151.1 {source="DOID:10544", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:187736009 {source="DOID:10544", source="MONDO:equivalentTo"} +xref: UMLS:C0153418 {source="DOID:10544", source="MONDO:equivalentTo"} +is_a: MONDO:0001056 {source="DOID:10544", source="MONDO:Entailed", source="MONDO:Redundant"} ! gastric cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001166 ! pylorus +relationship: disease_has_location UBERON:0001166 ! pylorus +property_value: exactMatch DOID:10544 +property_value: exactMatch http://identifiers.org/snomedct/187736009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153418 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001062 +name: pyloric antrum cancer +def: "A malignant neoplasm involving the pyloric antrum." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of pyloric antrum" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of antrum of stomach" EXACT [DOID:10547] +synonym: "malignant neoplasm of pyloric antrum" EXACT [MONDO:patterns/cancer] +synonym: "malignant pyloric antrum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of pyloric antrum" EXACT [DOID:10547] +synonym: "pyloric antrum cancer" EXACT [MONDO:patterns/location] +xref: DOID:10547 {source="MONDO:equivalentTo"} +xref: ICD9:151.2 {source="DOID:10547", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:187740000 {source="DOID:10547", source="MONDO:equivalentTo"} +xref: UMLS:C0153419 {source="DOID:10547", source="MONDO:equivalentTo"} +is_a: MONDO:0001061 {source="DOID:10547", source="MONDO:Entailed", source="MONDO:Redundant"} ! pylorus cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001165 ! pyloric antrum +relationship: disease_has_location UBERON:0001165 ! pyloric antrum +property_value: exactMatch DOID:10547 +property_value: exactMatch http://identifiers.org/snomedct/187740000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153419 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001063 +name: cardia cancer +def: "A malignant neoplasm involving the cardia of stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca cardia - stomach" EXACT [DOID:10548] +synonym: "cancer of cardia of stomach" EXACT [MONDO:patterns/cancer] +synonym: "cardia of stomach cancer" EXACT [MONDO:patterns/location] +synonym: "malignant cardia of stomach neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of cardia of stomach" EXACT [DOID:10548, MONDO:patterns/cancer] +xref: DOID:10548 {source="MONDO:equivalentTo"} +xref: ICD9:151.0 {source="DOID:10548", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:187732006 {source="DOID:10548", source="MONDO:equivalentTo"} +xref: UMLS:C0153417 {source="DOID:10548", source="MONDO:equivalentTo"} +is_a: MONDO:0001056 {source="DOID:10548", source="MONDO:Redundant"} ! gastric cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001162 ! cardia of stomach +relationship: disease_has_location UBERON:0001162 ! cardia of stomach +property_value: exactMatch DOID:10548 +property_value: exactMatch http://identifiers.org/snomedct/187732006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153417 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001064 +name: acute eustachian salpingitis +def: "Acute form of otosalpingitis." [MONDO:patterns/acute] +synonym: "acute eustachian tube salpingitis" EXACT [DOID:10550] +synonym: "acute otosalpingitis" EXACT [MONDO:design_pattern] +synonym: "otosalpingitis, acute" EXACT [MONDO:design_pattern, MONDO:patterns/acute] +xref: DOID:10550 {source="MONDO:equivalentTo"} +xref: ICD9:381.51 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10550"} +xref: SCTID:194268005 {source="MONDO:equivalentTo", source="DOID:10550"} +xref: UMLS:C0155429 {source="MONDO:equivalentTo", source="DOID:10550"} +is_a: MONDO:0002172 {source="DOID:10550", source="MONDO:Redundant"} ! otosalpingitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0002172 ! otosalpingitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:10550 +property_value: exactMatch http://identifiers.org/snomedct/194268005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155429 + +[Term] +id: MONDO:0001081 +name: acute cervicitis +def: "Acute inflammation of the cervix. Clinical manifestations include mucopurulent vaginal discharge and burning sensation." [NCIT:P378] +synonym: "acute cervicitis (disease)" EXACT [] +synonym: "cervicitis (disease), acute" EXACT [MONDO:patterns/acute] +xref: DOID:10616 {source="MONDO:equivalentTo"} +xref: NCIT:C27056 {source="DOID:10616", source="MONDO:equivalentTo"} +xref: SCTID:19272000 {source="DOID:10616", source="MONDO:equivalentTo"} +xref: UMLS:C0269061 {source="NCIT:C27056", source="DOID:10616", source="MONDO:equivalentTo"} +is_a: MONDO:0002345 {source="DOID:10616", source="MONDO:Redundant", source="NCIT:C27056"} ! cervicitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0002345 ! cervicitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:10616 +property_value: exactMatch http://identifiers.org/snomedct/19272000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0269061 +property_value: exactMatch NCIT:C27056 + +[Term] +id: MONDO:0001082 +name: lymph node cancer +def: "A primary or metastatic malignant tumor involving the lymph node. Lymphomas and metastatic carcinomas are representative examples. -- 2004" [NCIT:C35812] +synonym: "cancer of lymph node" EXACT [MONDO:patterns/cancer] +synonym: "lymph node cancer" EXACT [MONDO:patterns/location, NCIT:C35812] +synonym: "lymph node neoplasm" BROAD [DOID:10619, NCIT:C35497] +synonym: "malignant lymph node neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C35812] +synonym: "malignant neoplasm of lymph node" EXACT [MONDO:patterns/cancer] +xref: DOID:10619 {source="MONDO:equivalentTo"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C35812 {source="MONDO:equivalentTo"} +xref: SCTID:127232002 {source="MONDO:equivalentTo", source="DOID:10619"} +is_a: MONDO:0000612 {source="DOID:10619", source="MONDO:Entailed", source="MONDO:Redundant"} ! lymphatic system cancer +is_a: MONDO:0024339 {source="MONDO:Redundant", source="NCIT:C35812"} ! lymph node neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000029 ! lymph node +property_value: exactMatch DOID:10619 +property_value: exactMatch http://identifiers.org/snomedct/127232002 +property_value: exactMatch NCIT:C35812 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001106 +name: kidney failure +def: "An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood." [NCIT:P378] +synonym: "failure, renal" EXACT [NCIT:C4376] +synonym: "renal failure" EXACT [DOID:1074] +synonym: "renal failure syndrome" EXACT [NCIT:C4376] +synonym: "renal insufficiency" EXACT [NCIT:C4376] +xref: DOID:1074 {source="MONDO:equivalentTo"} +xref: ICD9:404.12 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:404.13 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:586 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1074"} +xref: MESH:D051437 {source="MONDO:equivalentTo", source="DOID:1074"} +xref: NCIT:C4376 {source="MONDO:equivalentTo", source="DOID:1074"} +xref: SCTID:42399005 {source="MONDO:equivalentTo", source="DOID:1074"} +xref: UMLS:C0035078 {source="MONDO:equivalentTo", source="NCIT:C4376", source="DOID:1074"} +xref: UMLS:C1565489 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="DOID:1074", source="MESH:D051437", source="NCIT:C4376/inferred"} ! kidney disorder +property_value: exactMatch DOID:1074 +property_value: exactMatch http://identifiers.org/mesh/D051437 +property_value: exactMatch http://identifiers.org/snomedct/42399005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035078 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1565489 +property_value: exactMatch NCIT:C4376 + +[Term] +id: MONDO:0001108 +name: broad ligament malignant neoplasm +def: "A malignant neoplasm involving the broad ligament of uterus." [https://orcid.org/0000-0002-6601-2165] +synonym: "broad ligament of uterus cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of broad ligament of uterus" EXACT [MONDO:patterns/cancer] +synonym: "malignant broad ligament of uterus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of broad ligament of uterus" EXACT [DOID:10744, ICD9CM:183.3, MONDO:patterns/cancer] +xref: DOID:10744 {source="MONDO:equivalentTo"} +xref: ICD9:183.3 {source="DOID:10744", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:449259009 {source="DOID:10744", source="MONDO:equivalentTo"} +xref: UMLS:C0346866 {source="DOID:10744", source="MONDO:equivalentTo"} +is_a: MONDO:0000637 ! musculoskeletal system cancer +is_a: MONDO:0001351 {source="DOID:10744"} ! uterine adnexa cancer +is_a: MONDO:0045043 ! disorder of uterine broad ligament +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0012332 ! broad ligament of uterus +property_value: exactMatch DOID:10744 +property_value: exactMatch http://identifiers.org/snomedct/449259009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346866 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001109 +name: petrositis +def: "Inflammation of petrous bone." [MESH:D059270] +synonym: "acute petrositis" EXACT [DOID:10755] +synonym: "chronic petrositis" EXACT [DOID:10755] +synonym: "inflammation of petrous bone" RELATED [DOID:10755] +synonym: "inflammation of petrous part of temporal bone" EXACT [] +synonym: "petrous part of temporal bone inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10755 {source="MONDO:equivalentTo"} +xref: ICD10CM:H70.2 {source="DOID:10755", source="MONDO:equivalentTo"} +xref: ICD9:383.2 {source="DOID:10755"} +xref: ICD9:383.20 {source="DOID:10755"} +xref: ICD9:383.21 {source="DOID:10755"} +xref: ICD9:383.22 {source="DOID:10755", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D059270 {source="DOID:10755", source="MONDO:equivalentTo"} +xref: SCTID:28593007 {source="DOID:10755", source="MONDO:equivalentTo"} +xref: UMLS:C0155448 {source="DOID:10755", source="MONDO:equivalentTo"} +is_a: MONDO:0005246 {source="DOID:10755", source="MESH:D059270"} ! osteomyelitis +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0024654 ! skull disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001694 ! petrous part of temporal bone +relationship: disease_has_feature HP:0002754 ! Osteomyelitis +relationship: disease_has_inflammation_site UBERON:0001694 ! petrous part of temporal bone +property_value: exactMatch DOID:10755 +property_value: exactMatch http://identifiers.org/mesh/D059270 +property_value: exactMatch http://identifiers.org/snomedct/28593007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155448 +property_value: exactMatch https://icd.codes/icd10cm/H70.2 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001116 +name: mesenteric lymphadenitis +def: "Inflammation of the mesenteric lymph nodes." [NCIT:P378] +synonym: "lymphadenitis (disease) of mesentery" EXACT [] +synonym: "mesenteric adenitis" EXACT [DOID:10782] +synonym: "mesenteric lymphadenitis" EXACT [DOID:10782] +synonym: "mesentery lymphadenitis (disease)" EXACT [MONDO:patterns/location] +xref: DOID:10782 {source="MONDO:equivalentTo"} +xref: ICD9:289.2 {source="DOID:10782"} +xref: MESH:D008640 {source="MONDO:equivalentTo", source="DOID:10782"} +xref: NCIT:C26830 {source="MONDO:equivalentTo", source="DOID:10782"} +xref: SCTID:44897000 {source="MONDO:equivalentTo", source="DOID:10782"} +xref: UMLS:C0025469 {source="MONDO:equivalentTo", source="NCIT:C26830", source="DOID:10782"} +is_a: MONDO:0002052 {source="DOID:10782", source="MESH:D008640", source="MONDO:Redundant", source="NCIT:C26830"} ! lymphadenitis +intersection_of: MONDO:0002052 ! lymphadenitis +intersection_of: disease_has_location UBERON:0002095 ! mesentery +relationship: disease_has_location UBERON:0002095 ! mesentery +property_value: exactMatch DOID:10782 +property_value: exactMatch http://identifiers.org/mesh/D008640 +property_value: exactMatch http://identifiers.org/snomedct/44897000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025469 +property_value: exactMatch NCIT:C26830 + +[Term] +id: MONDO:0001120 +name: chronic frontal sinusitis +def: "Inflammation of the frontal sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties." [NCIT:P378] +synonym: "frontal sinusitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:10790 {source="MONDO:equivalentTo"} +xref: ICD10CM:J32.1 {source="MONDO:equivalentTo", source="DOID:10790"} +xref: ICD9:473.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10790"} +xref: NCIT:C34473 {source="MONDO:equivalentTo", source="DOID:10790"} +xref: SCTID:60130002 {source="MONDO:equivalentTo", source="DOID:10790"} +xref: UMLS:C0008683 {source="NCIT:C34473", source="MONDO:equivalentTo", source="DOID:10790"} +is_a: MONDO:0001121 {source="DOID:10790", source="MONDO:Redundant", source="NCIT:C34473"} ! frontal sinusitis +is_a: MONDO:0006031 {source="MONDO:Redundant", source="NCIT:C34473"} ! chronic rhinosinusitis +intersection_of: MONDO:0001121 ! frontal sinusitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:10790 +property_value: exactMatch http://identifiers.org/snomedct/60130002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008683 +property_value: exactMatch https://icd.codes/icd10cm/J32.1 +property_value: exactMatch NCIT:C34473 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0001121 +name: frontal sinusitis +def: "An acute or chronic inflammatory process affecting the mucous membrane of the frontal sinus." [NCIT:P378] +xref: DOID:10791 {source="MONDO:equivalentTo"} +xref: MESH:D015522 {source="MONDO:equivalentTo", source="DOID:10791"} +xref: NCIT:C34626 {source="MONDO:equivalentTo", source="DOID:10791"} +xref: SCTID:78737005 {source="MONDO:equivalentTo", source="DOID:10791"} +xref: UMLS:C0016735 {source="MONDO:equivalentTo", source="DOID:10791", source="NCIT:C34626"} +is_a: MONDO:0005961 {source="DOID:10791", source="MESH:D015522", source="MONDO:Redundant", source="NCIT:C34626"} ! sinusitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001760 ! frontal sinus +relationship: disease_has_inflammation_site UBERON:0001760 ! frontal sinus +property_value: exactMatch DOID:10791 +property_value: exactMatch http://identifiers.org/mesh/D015522 +property_value: exactMatch http://identifiers.org/snomedct/78737005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0016735 +property_value: exactMatch NCIT:C34626 + +[Term] +id: MONDO:0001122 +name: chronic maxillary sinusitis +def: "Inflammation of the maxillary sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties." [NCIT:P378] +synonym: "chronic antritis" EXACT [DOID:10792] +synonym: "maxillary sinusitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:10792 {source="MONDO:equivalentTo"} +xref: ICD10CM:J32.0 {source="MONDO:equivalentTo", source="DOID:10792"} +xref: ICD9:473.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10792"} +xref: NCIT:C34477 {source="MONDO:equivalentTo", source="DOID:10792"} +xref: SCTID:35923002 {source="MONDO:equivalentTo", source="DOID:10792"} +xref: UMLS:C0008698 {source="MONDO:equivalentTo", source="NCIT:C34477", source="DOID:10792"} +is_a: MONDO:0005842 {source="DOID:10792", source="MONDO:Redundant", source="NCIT:C34477"} ! maxillary sinusitis +is_a: MONDO:0006031 ! chronic rhinosinusitis +intersection_of: MONDO:0005842 ! maxillary sinusitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:10792 +property_value: exactMatch http://identifiers.org/snomedct/35923002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008698 +property_value: exactMatch https://icd.codes/icd10cm/J32.0 +property_value: exactMatch NCIT:C34477 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0001123 +name: chronic sphenoidal sinusitis +def: "Inflammation of the sphenoid sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties." [NCIT:P378] +synonym: "chronic sphenoid sinusitis" EXACT [MONDO:design_pattern] +synonym: "sphenoid sinusitis, chronic" EXACT [MONDO:patterns/chronic] +synonym: "sphenoidal sinus-chr." EXACT [DOID:10793] +xref: DOID:10793 {source="MONDO:equivalentTo"} +xref: ICD10CM:J32.3 {source="MONDO:equivalentTo", source="DOID:10793"} +xref: ICD9:473.3 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10793"} +xref: NCIT:C34480 {source="MONDO:equivalentTo", source="DOID:10793"} +xref: SCTID:38961000 {source="MONDO:equivalentTo", source="DOID:10793"} +xref: UMLS:C0008712 {source="NCIT:C34480", source="MONDO:equivalentTo", source="DOID:10793"} +is_a: MONDO:0005964 {source="DOID:10793", source="MONDO:Redundant", source="NCIT:C34480"} ! sphenoid sinusitis +is_a: MONDO:0006031 ! chronic rhinosinusitis +intersection_of: MONDO:0005964 ! sphenoid sinusitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:10793 +property_value: exactMatch http://identifiers.org/snomedct/38961000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008712 +property_value: exactMatch https://icd.codes/icd10cm/J32.3 +property_value: exactMatch NCIT:C34480 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0001128 +name: nasal cavity cancer +def: "A malignant neoplasm involving the nasal cavity" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of nasal cavity" EXACT [MONDO:patterns/cancer] +synonym: "malignant nasal cavity neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4918] +synonym: "malignant nasal cavity tumor" EXACT [NCIT:C4918] +synonym: "malignant neoplasm of nasal cavities" EXACT [DOID:10811, ICD9CM:160.0] +synonym: "malignant neoplasm of nasal cavity" EXACT [MONDO:patterns/cancer, NCIT:C4918] +synonym: "malignant neoplasm of the nasal cavity" EXACT [NCIT:C4918] +synonym: "malignant tumor of nasal cavity" EXACT [NCIT:C4918] +synonym: "malignant tumor of the nasal cavity" EXACT [DOID:10811, NCIT:C4918] +synonym: "nasal cavity cancer" EXACT [MONDO:patterns/location] +xref: DOID:10811 {source="MONDO:equivalentTo"} +xref: ICD9:160.0 {source="DOID:10811", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4918 {source="DOID:10811", source="MONDO:equivalentTo"} +xref: SCTID:363422006 {source="DOID:10811", source="MONDO:equivalentTo"} +xref: UMLS:C0728864 {source="DOID:10811", source="NCIT:C4918", source="MONDO:equivalentTo"} +is_a: MONDO:0000376 {source="DOID:10811", source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0000649 ! sensory system cancer +is_a: MONDO:0004756 {source="MONDO:Redundant", source="NCIT:C4918"} ! nasal cavity neoplasm +is_a: MONDO:0005627 {source="MONDO:Redundant", source="NCIT:C4918"} ! head and neck cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:10811 +property_value: exactMatch http://identifiers.org/snomedct/363422006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0728864 +property_value: exactMatch NCIT:C4918 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001130 +name: nasal cavity lymphoma +def: "A primary lymphoma that affects the nasal cavity and the bulk of the tumor is in this anatomic area." [NCIT:C6074] +synonym: "lymphoma of nasal cavity" EXACT [DOID:10813, NCIT:C6074] +synonym: "lymphoma of the nasal cavity" EXACT [DOID:10813, NCIT:C6074] +synonym: "nasal cavity lymphoma" EXACT [MONDO:patterns/location, NCIT:C6074] +synonym: "primary nasal cavity lymphoma" EXACT [NCIT:C6074] +xref: DOID:10813 {source="MONDO:equivalentTo"} +xref: NCIT:C6074 {source="MONDO:equivalentTo", source="DOID:10813", source="MONDO:exact-label-match"} +xref: UMLS:C1334921 {source="MONDO:equivalentTo", source="DOID:10813", source="NCIT:C6074"} +is_a: MONDO:0001128 {source="DOID:10813", source="NCIT:C6074"} ! nasal cavity cancer +is_a: MONDO:0005062 {source="DOID:10813", source="MONDO:Redundant", source="NCIT:C6074/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:10813 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334921 +property_value: exactMatch NCIT:C6074 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001134 +name: essential hypertension +def: "Hypertension that presents without an identifiable cause." [NCIT:P378] +synonym: "idiopathic hypertension" EXACT [DOID:10825, Wikipedia:Essential_hypertension] +synonym: "primary hypertension" EXACT [DOID:10825, NCIT:C3478, Wikipedia:Essential_hypertension] +xref: DOID:10825 {source="MONDO:equivalentTo"} +xref: EFO:1002032 {source="MONDO:equivalentTo"} +xref: ICD9:401 {source="DOID:10825"} +xref: ICD9:401.9 {source="DOID:10825", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D000075222 {source="MONDO:equivalentTo"} +xref: NCIT:C3478 {source="DOID:10825", source="MONDO:otherHierarchy"} +xref: Orphanet:243761 {source="DOID:10825", source="MONDO:equivalentTo"} +xref: SCTID:59621000 {source="DOID:10825", source="MONDO:equivalentTo"} +xref: UMLS:C0085580 {source="DOID:10825", source="MONDO:equivalentTo"} +is_a: MONDO:0005044 {source="DOID:10825", source="EFO:1002032", source="MESH:C562386"} ! hypertensive disorder +property_value: exactMatch DOID:10825 +property_value: exactMatch http://identifiers.org/mesh/D000075222 +property_value: exactMatch http://identifiers.org/snomedct/59621000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085580 +property_value: exactMatch Orphanet:243761 +property_value: relatedMatch NCIT:C3478 + +[Term] +id: MONDO:0001142 +name: salivary gland disorder +def: "A disease involving the saliva-secreting gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of saliva-secreting gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of saliva-secreting gland" EXACT [] +synonym: "disorder of saliva-secreting gland" EXACT [MONDO:patterns/location_top] +synonym: "non-neoplastic salivary gland disease" EXACT [DOID:10854, NCIT:C27662] +synonym: "saliva-secreting gland disease" EXACT [MONDO:patterns/location] +synonym: "saliva-secreting gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "salivary gland disease" EXACT [DOID:10854, NCIT:C26879] +synonym: "salivary gland disorder" EXACT [NCIT:C26879] +xref: DOID:10854 {source="MONDO:equivalentTo"} +xref: EFO:0008581 {source="MONDO:equivalentTo"} +xref: ICD9:527.8 {source="DOID:10854", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:527.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D012466 {source="MONDO:equivalentTo"} +xref: NCIT:C26879 {source="MONDO:equivalentTo"} +xref: SCTID:10890000 {source="MONDO:equivalentTo"} +xref: UMLS:C0036093 {source="MONDO:equivalentTo", source="NCIT:C26879"} +is_a: MONDO:0006858 {source="DOID:10854", source="EFO:0008581", source="MESH:D012466", source="MONDO:Redundant"} ! mouth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +relationship: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch DOID:10854 +property_value: exactMatch http://identifiers.org/mesh/D012466 +property_value: exactMatch http://identifiers.org/snomedct/10890000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036093 +property_value: exactMatch NCIT:C26879 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001165 +name: tongue disorder +def: "A disease involving the tongue." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of tongue" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of tongue" EXACT [] +synonym: "disorder of tongue" EXACT [MONDO:patterns/location_top] +synonym: "tongue disease" EXACT [MONDO:patterns/location] +synonym: "tongue disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:10944 {source="MONDO:equivalentTo"} +xref: ICD9:529.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:529.9 {source="DOID:10944", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014060 {source="DOID:10944", source="MONDO:equivalentTo"} +xref: SCTID:69244009 {source="DOID:10944", source="MONDO:equivalentTo"} +xref: UMLS:C0040409 {source="DOID:10944", source="MONDO:equivalentTo"} +is_a: MONDO:0006858 {source="DOID:10944", source="MESH:D014060", source="MONDO:Redundant"} ! mouth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001723 ! tongue +relationship: disease_has_location UBERON:0001723 ! tongue +property_value: exactMatch DOID:10944 +property_value: exactMatch http://identifiers.org/mesh/D014060 +property_value: exactMatch http://identifiers.org/snomedct/69244009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040409 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001166 +name: nephritis +def: "Inflammation of renal tissue." [NCIT:P378] +synonym: "inflammation of kidney" EXACT [] +synonym: "kidney inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10952 {source="MONDO:equivalentTo"} +xref: ICD9:583.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:583.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:583.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009393 {source="DOID:10952", source="MONDO:equivalentTo"} +xref: NCIT:C26833 {source="DOID:10952", source="MONDO:equivalentTo"} +xref: SCTID:52845002 {source="DOID:10952", source="MONDO:equivalentTo"} +xref: UMLS:C0027697 {source="DOID:10952", source="MONDO:equivalentTo", source="NCIT:C26833"} +is_a: MONDO:0005240 {source="DOID:10952", source="MESH:D009393", source="MONDO:Redundant", source="NCIT:C26833/inferred"} ! kidney disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002113 ! kidney +relationship: disease_has_inflammation_site UBERON:0002113 ! kidney +property_value: exactMatch DOID:10952 +property_value: exactMatch http://identifiers.org/mesh/D009393 +property_value: exactMatch http://identifiers.org/snomedct/52845002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027697 +property_value: exactMatch NCIT:C26833 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001171 +name: acute salpingo-oophoritis +def: "Acute form of salpingo-oophoritis." [MONDO:patterns/acute] +synonym: "acute salpingitis and oophoritis" EXACT [DOID:10971, ICD9CM:614.0] +synonym: "salpingo-oophoritis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:10971 {source="MONDO:equivalentTo"} +xref: ICD9:614.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10971"} +xref: SCTID:266581008 {source="MONDO:equivalentTo", source="DOID:10971"} +xref: UMLS:C0156327 {source="MONDO:equivalentTo", source="DOID:10971"} +is_a: MONDO:0001172 {source="DOID:10971", source="MONDO:Redundant"} ! salpingo-oophoritis +is_a: MONDO:0001173 {source="MONDO:Redundant"} ! acute salpingitis +intersection_of: MONDO:0001172 ! salpingo-oophoritis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:10971 +property_value: exactMatch http://identifiers.org/snomedct/266581008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0156327 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0001172 +name: salpingo-oophoritis +synonym: "salpingitis/oophoritis" EXACT [DOID:10972] +synonym: "tubo ovarian abscess" EXACT [https://orcid.org/0000-0002-8169-9049, OMOP:4239651, SCTID:58949002] +synonym: "tubo-ovarian abscess" EXACT [https://orcid.org/0000-0002-8169-9049, OMOP:4239651, SCTID:58949002] +synonym: "tubo-ovarian abscess (disorder)" EXACT [https://orcid.org/0000-0002-8169-9049, OMOP:4239651, SCTID:58949002] +synonym: "Tubo-ovarian inflammatory disease" EXACT [DOID:10972] +xref: DOID:10972 {source="MONDO:equivalentTo"} +xref: ICD9:614.2 {source="DOID:10972", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:46536000 {source="DOID:10972", source="MONDO:equivalentTo"} +xref: UMLS:C0036133 {source="DOID:10972", source="MONDO:equivalentTo"} +is_a: MONDO:0003619 {source="DOID:10972", source="MONDO:Redundant"} ! salpingitis +is_a: MONDO:0006877 {source="DOID:10972", source="MONDO:Redundant"} ! oophoritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000992 ! ovary +intersection_of: disease_has_inflammation_site UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:10972 +property_value: exactMatch http://identifiers.org/snomedct/46536000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036133 + +[Term] +id: MONDO:0001173 +name: acute salpingitis +def: "Acute inflammation of the fallopian tube. It is most often caused by Neisseria gonorrhoeae and Chlamydia trachomatis infections. The infections usually originate in the vagina and ascend to the fallopian tube. Symptoms include abdominal, pelvic, and lower back pain, pain during ovulation and sexual intercourse, fever, nausea, and vomiting. Complications include infertility and ectopic pregnancy." [NCIT:P378] +synonym: "salpingitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:10973 {source="MONDO:equivalentTo"} +xref: ICD10CM:N70.01 {source="DOID:10973", source="MONDO:equivalentTo"} +xref: NCIT:C40120 {source="DOID:10973", source="MONDO:equivalentTo"} +xref: SCTID:8912009 {source="DOID:10973", source="MONDO:equivalentTo"} +xref: UMLS:C0269038 {source="DOID:10973", source="MONDO:equivalentTo", source="NCIT:C40120"} +is_a: MONDO:0003619 {source="DOID:10973", source="MONDO:Redundant", source="NCIT:C40120"} ! salpingitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0003619 ! salpingitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:10973 +property_value: exactMatch http://identifiers.org/snomedct/8912009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0269038 +property_value: exactMatch https://icd.codes/icd10cm/N70.01 +property_value: exactMatch NCIT:C40120 + +[Term] +id: MONDO:0001174 +name: conjunctival vascular disorder +def: "A disorder of the vasculature of the cornea." [NCIT:P378] +synonym: "conjunctival vascular abnormality" EXACT [DOID:10989] +synonym: "conjunctival vascular disorder" EXACT [NCIT:C35116] +synonym: "conjunctival vasculature disease" EXACT [MONDO:patterns/location] +synonym: "conjunctival vasculature disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of conjunctival vasculature" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of conjunctival vasculature" EXACT [] +synonym: "disorder of conjunctival vasculature" EXACT [MONDO:patterns/location_top] +synonym: "vascular abnormalities of conjunctiva" EXACT [DOID:10989, ICD9CM:372.74] +xref: DOID:10989 {source="MONDO:equivalentTo"} +xref: ICD9:372.74 {source="MONDO:equivalentTo", source="DOID:10989", source="MONDO:i2s"} +xref: NCIT:C35116 {source="MONDO:equivalentTo", source="DOID:10989"} +xref: SCTID:74100001 {source="MONDO:equivalentTo", source="DOID:10989"} +is_a: MONDO:0005552 ! ocular vascular disorder +is_a: MONDO:0006170 {source="DOID:10989", source="MONDO:Redundant"} ! conjunctival disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0010366 ! conjunctival vasculature +relationship: disease_has_location UBERON:0010366 ! conjunctival vasculature +property_value: exactMatch DOID:10989 +property_value: exactMatch http://identifiers.org/snomedct/74100001 +property_value: exactMatch NCIT:C35116 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001176 +name: lens disorder +def: "A disease involving the lens of camera-type eye." [https://orcid.org/0000-0002-6601-2165] +comment: Includes cataracts, lens subluxation and aphakia +synonym: "disease of lens of camera-type eye" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lens of camera-type eye" EXACT [] +synonym: "disorder of lens of camera-type eye" EXACT [MONDO:patterns/location_top] +synonym: "lens disorder" EXACT [NCIT:C26812] +synonym: "lens of camera-type eye disease" EXACT [MONDO:patterns/location] +synonym: "lens of camera-type eye disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:110 {source="MONDO:equivalentTo"} +xref: ICD10CM:H25-H28 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="DOID:110", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:379.39 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007905 {source="MONDO:equivalentTo", source="DOID:110"} +xref: NCIT:C26812 {source="MONDO:equivalentTo", source="DOID:110"} +xref: SCTID:10810001 {source="MONDO:equivalentTo", source="DOID:110"} +xref: UMLS:C0023308 {source="MONDO:equivalentTo", source="DOID:110", source="NCIT:C26812"} +is_a: MONDO:0005328 {source="DOID:110", source="MESH:D007905", source="MONDO:Redundant", source="NCIT:C26812"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000965 ! lens of camera-type eye +relationship: disease_has_location UBERON:0000965 ! lens of camera-type eye +property_value: exactMatch DOID:110 +property_value: exactMatch http://identifiers.org/mesh/D007905 +property_value: exactMatch http://identifiers.org/snomedct/10810001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023308 +property_value: exactMatch https://icd.codes/icd10cm/H25-H28 +property_value: exactMatch NCIT:C26812 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001187 +name: urinary bladder cancer +def: "A primary or metastatic malignant neoplasm involving the bladder." [NCIT:C9334] +synonym: "bladder cancer, somatic" EXACT [OMIM:109800, OMIM:genemap2] +synonym: "cancer of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant bladder neoplasm" EXACT [NCIT:C9334] +synonym: "malignant bladder tumor" EXACT [NCIT:C9334] +synonym: "malignant neoplasm of bladder" EXACT [NCIT:C9334] +synonym: "malignant neoplasm of the bladder" EXACT [NCIT:C9334] +synonym: "malignant neoplasm of the urinary bladder" EXACT [NCIT:C9334] +synonym: "malignant neoplasm of urinary bladder" EXACT [MONDO:patterns/cancer, NCIT:C9334] +synonym: "malignant neoplasm, bladder" EXACT [NCIT:C9334] +synonym: "malignant neoplasm, urinary bladder" EXACT [NCIT:C9334] +synonym: "malignant tumor of bladder" EXACT [NCIT:C9334] +synonym: "malignant tumor of the bladder" EXACT [NCIT:C9334] +synonym: "malignant tumor of the urinary bladder" EXACT [NCIT:C9334] +synonym: "malignant tumor of urinary bladder" EXACT [NCIT:C9334] +synonym: "malignant tumor, urinary bladder" EXACT [NCIT:C9334] +synonym: "malignant urinary bladder neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9334] +synonym: "malignant urinary bladder tumor" EXACT [NCIT:C9334] +synonym: "tumor of the bladder" BROAD [DOID:11054, NCIT:C2901] +synonym: "urinary bladder cancer" EXACT [MONDO:patterns/location] +synonym: "urinary bladder malignant neoplasm" EXACT [NCIT:C9334] +synonym: "urinary bladder malignant tumor" EXACT [NCIT:C9334] +xref: DOID:11054 {source="MONDO:equivalentTo"} +xref: ICD9:188 {source="DOID:11054"} +xref: ICD9:188.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:188.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11054"} +xref: KEGG:05219 {source="MONDO:relatedTo", source="DOID:11054"} +xref: NCIT:C9334 {source="MONDO:equivalentTo", source="DOID:11054"} +xref: OMIM:109800 {source="MONDO:equivalentTo", source="DOID:11054"} +xref: Orphanet:157980 {source="MONDO:equivalentTo"} +xref: SCTID:399326009 {source="MONDO:equivalentTo", source="DOID:11054"} +xref: UMLS:C0005684 {source="NCIT:C9334", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="DOID:11054"} +is_a: MONDO:0004987 {source="MONDO:Redundant", source="NCIT:C9334"} ! urinary bladder neoplasm +is_a: MONDO:0006295 {source="DOID:11054", source="MONDO:Redundant", source="NCIT:C9334"} ! malignant urinary system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:11054 +property_value: exactMatch http://identifiers.org/snomedct/399326009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005684 +property_value: exactMatch https://omim.org/entry/109800 +property_value: exactMatch NCIT:C9334 +property_value: exactMatch Orphanet:157980 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0001188 +name: esophagus lymphoma +def: "An extranodal lymphoma that arises from the esophagus with the bulk of the mass located in the esophagus. Dysphagia may be the presenting symptom. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue." [NCIT:P378] +synonym: "esophageal lymphoma" EXACT [NCIT:C5687] +synonym: "esophagus lymphoma" EXACT [MONDO:patterns/location, NCIT:C5687] +synonym: "lymphoma of esophagus" EXACT [DOID:1106, NCIT:C5687] +synonym: "lymphoma of the esophagus" EXACT [NCIT:C5687] +synonym: "primary esophageal lymphoma" EXACT [NCIT:C5687] +xref: DOID:1106 {source="MONDO:equivalentTo"} +xref: NCIT:C5687 {source="MONDO:equivalentTo", source="DOID:1106"} +xref: UMLS:C1333459 {source="MONDO:equivalentTo", source="DOID:1106", source="NCIT:C5687"} +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C5687"} ! gastrointestinal lymphoma +is_a: MONDO:0007576 {source="DOID:1106", source="MONDO:Redundant", source="NCIT:C5687"} ! esophageal cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch DOID:1106 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333459 +property_value: exactMatch NCIT:C5687 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001214 +name: acute conjunctivitis +def: "Acute inflammation of the conjunctiva." [NCIT:C35195] +synonym: "acute conjunctivitis (disease)" EXACT [] +synonym: "conjunctivitis (disease), acute" EXACT [MONDO:patterns/acute] +xref: DOID:11184 {source="MONDO:equivalentTo"} +xref: ICD9:372.00 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:372.03 {source="DOID:11184"} +xref: NCIT:C35195 {source="MONDO:equivalentTo"} +xref: SCTID:53726008 {source="MONDO:equivalentTo"} +xref: UMLS:C0155141 {source="NCIT:C35195", source="MONDO:equivalentTo"} +is_a: MONDO:0003799 {source="DOID:11184", source="MONDO:Redundant", source="NCIT:C35195"} ! conjunctivitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0003799 ! conjunctivitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:11184 +property_value: exactMatch http://identifiers.org/snomedct/53726008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155141 +property_value: exactMatch NCIT:C35195 + +[Term] +id: MONDO:0001223 +name: parathyroid gland disorder +def: "A disease involving the parathyroid gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of parathyroid gland" EXACT [MONDO:patterns/location_top] +synonym: "disease of parathyroid glands" EXACT [DOID:11201] +synonym: "disease or disorder of parathyroid gland" EXACT [] +synonym: "disorder of parathyroid gland" EXACT [MONDO:patterns/location_top] +synonym: "parathyroid disease" EXACT [MONDO:0005553] +synonym: "parathyroid gland disease" EXACT [MONDO:patterns/location, NCIT:C26844] +synonym: "parathyroid gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "parathyroid gland diseases" EXACT [NCIT:C26844] +synonym: "parathyroid gland disorder" EXACT [NCIT:C26844] +synonym: "parathyroid gland disorders" EXACT [NCIT:C26844] +xref: DOID:11201 {source="MONDO:equivalentTo"} +xref: EFO:0005754 {source="MONDO:equivalentTo"} +xref: ICD9:252 {source="DOID:11201"} +xref: ICD9:252.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:252.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11201"} +xref: MESH:D010279 {source="MONDO:equivalentTo", source="DOID:11201"} +xref: NCIT:C26844 {source="MONDO:equivalentTo", source="DOID:11201"} +xref: SCTID:73132005 {source="MONDO:equivalentTo", source="DOID:11201"} +xref: UMLS:C0030517 {source="MONDO:equivalentTo", source="NCIT:C26844", source="DOID:11201"} +is_a: MONDO:0005151 {source="DOID:11201", source="MESH:D010279", source="MONDO:Redundant"} ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +relationship: disease_has_location UBERON:0001132 ! parathyroid gland +property_value: exactMatch DOID:11201 +property_value: exactMatch http://identifiers.org/mesh/D010279 +property_value: exactMatch http://identifiers.org/snomedct/73132005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030517 +property_value: exactMatch NCIT:C26844 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001227 +name: chronic tympanitis +def: "Chronic form of tympanitis." [MONDO:patterns/chronic] +synonym: "tympanitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:11217 {source="MONDO:equivalentTo"} +xref: ICD9:384.1 {source="DOID:11217", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:89723004 {source="DOID:11217", source="MONDO:equivalentTo"} +xref: UMLS:C0395849 {source="DOID:11217", source="MONDO:equivalentTo"} +is_a: MONDO:0021204 ! chronic otitis media +is_a: MONDO:0024616 ! tympanitis +intersection_of: MONDO:0024616 ! tympanitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:11217 +property_value: exactMatch http://identifiers.org/snomedct/89723004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0395849 + +[Term] +id: MONDO:0001229 +name: small intestine diverticulitis +def: "A diverticulitis that involves the small intestine." [MONDO:patterns/location] +synonym: "diverticulitis of small intestine" EXACT [MONDO:design_pattern] +synonym: "diverticulosis of small intestine with hemorrhage" EXACT [DOID:11223] +synonym: "small intestine diverticulitis" EXACT [MONDO:patterns/location] +xref: DOID:11223 {source="MONDO:equivalentTo"} +xref: ICD9:562.01 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:562.02 {source="DOID:11223"} +xref: SCTID:56165008 {source="MONDO:equivalentTo"} +xref: UMLS:C0156164 {source="MONDO:equivalentObsolete", source="DOID:11223"} +is_a: MONDO:0004235 {source="DOID:11223", source="MONDO:Redundant"} ! diverticulitis +is_a: MONDO:0024635 ! small intestine disorder +intersection_of: MONDO:0004235 ! diverticulitis +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:11223 +property_value: exactMatch http://identifiers.org/snomedct/56165008 + +[Term] +id: MONDO:0001235 +name: appendix cancer +def: "A malignant neoplasm involving the vermiform appendix" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of the appendix" EXACT [DOID:11239, NCIT:C9330] +synonym: "cancer of vermiform appendix" EXACT [MONDO:patterns/cancer] +synonym: "malignant appendix neoplasm" EXACT [NCIT:C9333] +synonym: "malignant appendix tumor" EXACT [NCIT:C9333] +synonym: "malignant neoplasm of appendix" EXACT [NCIT:C9333] +synonym: "malignant neoplasm of appendix vermiformis" EXACT [DOID:11239, ICD9CM:153.5, NCIT:C9333] +synonym: "malignant neoplasm of the appendix" EXACT [NCIT:C9333] +synonym: "malignant neoplasm of vermiform appendix" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of appendix" EXACT [NCIT:C9333] +synonym: "malignant tumor of the appendix" EXACT [DOID:11239, NCIT:C9333] +synonym: "malignant vermiform appendix neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "vermiform appendix cancer" EXACT [MONDO:patterns/location] +xref: DOID:11239 {source="MONDO:equivalentTo"} +xref: ICD9:153.5 {source="DOID:11239", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9333 {source="DOID:11239", source="MONDO:equivalentTo"} +xref: SCTID:363411007 {source="DOID:11239", source="MONDO:equivalentTo"} +xref: UMLS:C0496779 {source="DOID:11239", source="NCIT:C9333", source="MONDO:equivalentTo"} +is_a: MONDO:0001236 {source="MONDO:Redundant", source="NCIT:C9333"} ! appendiceal neoplasm +is_a: MONDO:0002033 ! cecum cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:11239 +property_value: exactMatch http://identifiers.org/snomedct/363411007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496779 +property_value: exactMatch NCIT:C9333 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001236 +name: appendiceal neoplasm +def: "A benign or malignant neoplasm involving the appendix." [NCIT:P378] +synonym: "appendix neoplasm" EXACT [DOID:11240, NCIT:C4434] +synonym: "appendix tumor" EXACT [NCIT:C4434] +synonym: "neoplasm of appendix" EXACT [NCIT:C4434] +synonym: "neoplasm of the appendix" EXACT [NCIT:C4434] +synonym: "neoplasm of vermiform appendix" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of appendix" EXACT [NCIT:C4434] +synonym: "tumor of the appendix" EXACT [NCIT:C4434] +synonym: "tumor of vermiform appendix" EXACT [MONDO:patterns/neoplasm] +synonym: "vermiform appendix neoplasm" EXACT [] +synonym: "vermiform appendix neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "vermiform appendix tumor" EXACT [MONDO:patterns/neoplasm] +xref: DOID:11240 {source="MONDO:equivalentTo"} +xref: EFO:0003880 {source="MONDO:equivalentTo"} +xref: MESH:D001063 {source="MONDO:equivalentTo", source="DOID:11240"} +xref: NCIT:C4434 {source="MONDO:equivalentTo", source="DOID:11240"} +xref: SCTID:126846004 {source="MONDO:equivalentTo", source="DOID:11240"} +xref: UMLS:C0003614 {source="MONDO:equivalentTo", source="DOID:11240", source="NCIT:C4434"} +is_a: MONDO:0005694 {source="MESH:D001063", source="MONDO:Redundant"} ! cecal neoplasm +is_a: MONDO:0056798 ! disorder of appendix +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:11240 +property_value: exactMatch http://identifiers.org/mesh/D001063 +property_value: exactMatch http://identifiers.org/snomedct/126846004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003614 +property_value: exactMatch NCIT:C4434 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001237 +name: appendix lymphoma +def: "A lymphoma arising from the appendix. The majority of lymphomas affecting the appendix represent disease extension from the intestinal wall; primary lymphomas of the appendix are rare." [NCIT:C5513] +synonym: "appendiceal lymphoma" EXACT [DOID:11241, NCIT:C5513] +synonym: "appendix lymphoma" EXACT [NCIT:C5513] +synonym: "lymphoma of appendix" EXACT [NCIT:C5513] +synonym: "lymphoma of the appendix" EXACT [NCIT:C5513] +synonym: "lymphoma of vermiform appendix" EXACT [MONDO:design_pattern] +synonym: "primary appendix lymphoma" EXACT [NCIT:C5513] +synonym: "vermiform appendix lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:11241 {source="MONDO:equivalentTo"} +xref: NCIT:C5513 {source="MONDO:equivalentTo", source="DOID:11241", source="MONDO:exact-label-match"} +xref: UMLS:C1332328 {source="MONDO:equivalentTo", source="DOID:11241", source="NCIT:C5513"} +is_a: MONDO:0001235 {source="DOID:11241", source="MONDO:Redundant", source="NCIT:C5513"} ! appendix cancer +is_a: MONDO:0002034 ! cecum lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:11241 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332328 +property_value: exactMatch NCIT:C5513 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001269 +name: scleral disorder +def: "A disorder affecting the sclera. Examples include inflammatory processes (e.g., scleritis and episcleritis), and degenerative processes. Primary tumors of the sclera are extremely rare." [NCIT:P378] +synonym: "disease of sclera" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of sclera" EXACT [] +synonym: "disorder of sclera" EXACT [MONDO:patterns/location_top] +synonym: "sclera disease" EXACT [MONDO:patterns/location] +synonym: "sclera disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "sclera disorder" EXACT [NCIT:C79717] +synonym: "scleral disorder" EXACT [NCIT:C79717] +xref: DOID:11343 {source="MONDO:equivalentTo"} +xref: ICD9:379.19 +xref: MESH:D015422 {source="MONDO:equivalentTo", source="DOID:11343"} +xref: NCIT:C79717 {source="MONDO:equivalentTo", source="DOID:11343"} +xref: SCTID:33064008 {source="MONDO:equivalentTo", source="DOID:11343"} +xref: UMLS:C0036412 {source="MONDO:equivalentTo", source="DOID:11343"} +is_a: MONDO:0005328 {source="DOID:11343", source="MESH:D015422", source="MONDO:Redundant", source="NCIT:C79717"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001773 ! sclera +relationship: disease_has_location UBERON:0001773 ! sclera +property_value: exactMatch DOID:11343 +property_value: exactMatch http://identifiers.org/mesh/D015422 +property_value: exactMatch http://identifiers.org/snomedct/33064008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036412 +property_value: exactMatch NCIT:C79717 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001275 +name: spinal meningioma +def: "Spinal meningioma isa rare type of spinal cord cancer. The spinal cord is part of the central nervous system. This tumor often affects middle-aged women. Tumors of the spinal cord can be either primary or arise from other primary tumors (metastatic), and are typically slow growing. The initial signs and symptoms include headacheand recent onset of seizures. Other features are motor deficits, sensory deficits, pain, and sphincter dysfunction. The thoracic spine (middle back) is the most common site, followed by the cervical spine (neck). These tumors are rarely seen in the lumbar region (lower back). T he only proven risk factor in the development of meningioma is exposure to ionizing radiation. Also, patients with neurofibromatosis type 2 are at increased risk of developing meningioma. Surgery is the treatment of choice and complete tumor removal is reached in the vast majority of patients. The prognosis after surgical resection is excellent." [https://rarediseases.info.nih.gov/diseases/10264/spinal-meningioma] +subset: gard_rare {source="GARD:0010264"} +synonym: "meningioma (disease) of spinal cord" EXACT [] +synonym: "meningioma of spinal cord" EXACT [NCIT:C6935] +synonym: "meningioma of the spinal cord" EXACT [NCIT:C6935] +synonym: "meningioma, spine" RELATED [GARD:0010264] +synonym: "spinal cord meningioma" EXACT [DOID:1138, NCIT:C6935] +synonym: "spinal cord meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:1138 {source="MONDO:equivalentTo"} +xref: GARD:0010264 {source="MONDO:equivalentTo"} +xref: NCIT:C6935 {source="MONDO:equivalentTo", source="DOID:1138"} +xref: SCTID:189167009 {source="MONDO:equivalentTo", source="DOID:1138"} +xref: UMLS:C0347515 {source="MONDO:equivalentTo", source="DOID:1138", source="NCIT:C6935"} +is_a: MONDO:0001279 {source="DOID:1138", source="NCIT:C6935"} ! intraspinal meningioma +is_a: MONDO:0021234 ! spinal cord neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:1138 +property_value: exactMatch http://identifiers.org/snomedct/189167009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347515 +property_value: exactMatch NCIT:C6935 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/10264/spinal-meningioma xsd:anyURI {source="GARD:0010264"} + +[Term] +id: MONDO:0001277 +name: cerebral arteritis +def: "An inflammatory disease involving a pathogenic inflammatory response in the cerebral artery." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "cerebral artery inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of cerebral artery" EXACT [] +xref: DOID:11390 {source="MONDO:equivalentTo"} +xref: ICD9:437.4 {source="DOID:11390", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:28366008 {source="DOID:11390", source="MONDO:equivalentTo"} +xref: UMLS:C0007773 {source="DOID:11390", source="MONDO:equivalentTo"} +is_a: MONDO:0003346 ! central nervous system vasculitis +is_a: MONDO:0011057 {source="DOID:11390"} ! cerebrovascular disorder +is_a: MONDO:0043494 ! arteritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0004449 ! cerebral artery +relationship: disease_has_inflammation_site UBERON:0004449 ! cerebral artery +property_value: exactMatch DOID:11390 +property_value: exactMatch http://identifiers.org/snomedct/28366008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007773 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001279 +name: intraspinal meningioma +def: "A meningioma that arises from the spinal meninges." [NCIT:C5134] +synonym: "intraspinal meningioma" EXACT [NCIT:C5134] +synonym: "meningioma of spinal canal and spinal cord" EXACT [NCIT:C5134] +synonym: "meningioma of the spinal canal and spinal cord" EXACT [NCIT:C5134] +synonym: "spinal canal and spinal cord meningioma" EXACT [NCIT:C5134] +xref: DOID:1140 {source="MONDO:equivalentTo"} +xref: NCIT:C5134 {source="MONDO:equivalentTo", source="DOID:1140"} +xref: UMLS:C1334264 {source="NCIT:C5134", source="MONDO:equivalentTo", source="DOID:1140"} +is_a: MONDO:0016642 {source="NCIT:C5134/inferred"} ! meningioma +relationship: disease_arises_from_structure UBERON:0003292 ! meninx of spinal cord +property_value: exactMatch DOID:1140 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334264 +property_value: exactMatch NCIT:C5134 +property_value: excluded_subClassOf MONDO:0003544 {source="DOID:1140"} + +[Term] +id: MONDO:0001280 +name: choroiditis +def: "An inflammatory process that affects the choroid." [NCIT:C35111] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:280892"} +synonym: "Choroiditides" EXACT [MESH:D002833] +synonym: "choroiditis" EXACT [NCIT:C35111, Orphanet:280892] +synonym: "posterior uveitis" RELATED [MONDO:ambiguous, NCIT:C35111] +synonym: "posterior uveitis (disease)" RELATED [MONDO:0017254] +xref: DOID:11406 {source="MONDO:equivalentTo"} +xref: GARD:0006062 {source="MONDO:equivalentTo", source="MONDO:shared-xref"} +xref: HP:0012123 {source="MONDO:otherHierarchy"} +xref: ICD10CM:H30.0 {source="Orphanet:280892", source="Orphanet:280892/btnt"} +xref: ICD10CM:H30.1 {source="Orphanet:280892", source="Orphanet:280892/btnt"} +xref: ICD10CM:H30.2 {source="Orphanet:280892", source="Orphanet:280892/btnt"} +xref: ICD10CM:H30.8 {source="Orphanet:280892", source="Orphanet:280892/btnt"} +xref: ICD10CM:H30.9 {source="DOID:11406", source="Orphanet:280892", source="Orphanet:280892/btnt"} +xref: MedDRA:10036370 {source="Orphanet:280892", source="Orphanet:280892/e"} +xref: MESH:D002833 {source="DOID:11406", source="MONDO:equivalentTo"} +xref: NCIT:C35111 {source="DOID:11406", source="MONDO:equivalentTo"} +xref: Orphanet:280892 {source="MONDO:equivalentTo"} +xref: SCTID:16553002 {source="DOID:11406", source="MONDO:equivalentTo"} +xref: UMLS:C0008526 {source="DOID:11406", source="MONDO:equivalentTo", source="Orphanet:280892"} +xref: UMLS:C0042167 {source="NCIT:C35111", source="MONDO:equivalentTo", source="Orphanet:280892", source="Orphanet:280892/e"} +is_a: MONDO:0001898 {source="DOID:11406", source="MESH:D002833", source="MONDO:Redundant"} ! optic choroid disorder +is_a: MONDO:0006918 ! posterior uveitis +is_a: MONDO:0018882 ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001776 ! optic choroid +relationship: disease_has_inflammation_site UBERON:0001776 ! optic choroid +property_value: broadMatch https://icd.codes/icd10cm/H30.0 +property_value: broadMatch https://icd.codes/icd10cm/H30.1 +property_value: broadMatch https://icd.codes/icd10cm/H30.2 +property_value: broadMatch https://icd.codes/icd10cm/H30.8 +property_value: broadMatch https://icd.codes/icd10cm/H30.9 +property_value: closeMatch http://identifiers.org/meddra/10036370 +property_value: exactMatch DOID:11406 +property_value: exactMatch http://identifiers.org/mesh/D002833 +property_value: exactMatch http://identifiers.org/snomedct/16553002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008526 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042167 +property_value: exactMatch NCIT:C35111 +property_value: exactMatch Orphanet:280892 + +[Term] +id: MONDO:0001290 +name: allergic cutaneous vasculitis +def: "Inflammation of the small vessels of the skin that is mediated by the immune system." [NCIT:C35119] +synonym: "allergic cutaneous angiitis" EXACT [DOID:11450, NCIT:C35119] +synonym: "autoimmune hypersensitivity angiitis" EXACT [DOID:11450] +xref: DOID:11450 {source="MONDO:equivalentTo"} +xref: NCIT:C35119 {source="MONDO:equivalentTo"} +is_a: MONDO:0004980 ! atopic eczema +is_a: MONDO:0006794 {source="DOID:11450", source="MONDO:Redundant"} ! hypersensitivity vasculitis +is_a: MONDO:0020576 ! cutaneous vasculitis +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +intersection_of: disease_has_inflammation_site UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:11450 +property_value: exactMatch NCIT:C35119 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0001292 +name: autonomic nervous system disorder +def: "A disease involving the autonomic nervous system." [https://orcid.org/0000-0002-6601-2165] +comment: Editor note: We follow uberon and treat ANS as part of PNS. TODO - curate subtypes from http://neuromuscular.wustl.edu/autonomic.html +synonym: "ANS (autonomic nervous system) diseases" RELATED [MESH:D001342] +synonym: "ANS disease" RELATED [MESH:D001342] +synonym: "ANS diseases" RELATED [MESH:D001342] +synonym: "autonomic central nervous system diseases" RELATED [MESH:D001342] +synonym: "autonomic disease" RELATED [MESH:D001342] +synonym: "autonomic diseases" RELATED [MESH:D001342] +synonym: "autonomic dysfunction, segmental" RELATED [MESH:D001342] +synonym: "autonomic dysfunctions, segmental" RELATED [MESH:D001342] +synonym: "autonomic nervous disease" EXACT [DOID:11465] +synonym: "autonomic nervous system disease" EXACT [MONDO:patterns/location] +synonym: "autonomic nervous system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "autonomic nervous system disorder" EXACT [DOID:11465] +synonym: "autonomic nervous system disorders" RELATED [MESH:D001342] +synonym: "autonomic peripheral nervous system diseases" NARROW [MESH:D001342] +synonym: "central autonomic nervous system diseases" RELATED [MESH:D001342] +synonym: "disease of autonomic nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of autonomic nervous system" EXACT [] +synonym: "disorder of autonomic nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disorder of peripheral autonomic nervous system" EXACT [] +synonym: "disorder of the autonomic nervous system" EXACT [ISBN-13:978-1-259-64403-0] +synonym: "disorders of the autonomic nervous system" RELATED [MESH:D001342] +synonym: "dysautonomia" NARROW [] +synonym: "nervous system diseases, autonomic" RELATED [MESH:D001342] +synonym: "nervous system diseases, sympathetic" RELATED [MESH:D001342] +synonym: "peripheral autonomic nervous system diseases" NARROW [MESH:D001342] +synonym: "segmental autonomic dysfunction" RELATED [MESH:D001342] +synonym: "segmental autonomic dysfunctions" RELATED [MESH:D001342] +xref: DOID:11465 {source="MONDO:equivalentTo"} +xref: ICD9:337.1 {source="DOID:11465"} +xref: ICD9:337.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001342 {source="MONDO:equivalentTo"} +xref: SCTID:128123007 {source="MONDO:equivalentTo"} +xref: SCTID:15241006 {source="MONDO:equivalentTo"} +is_a: MONDO:0002602 {source="ISBN-13:978-1-259-64403-0"} ! central nervous system disorder +is_a: MONDO:0003620 {source="DOID:11465", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002410 ! autonomic nervous system +relationship: disease_has_location UBERON:0002410 ! autonomic nervous system +relationship: disease_has_major_feature HP:0012332 ! Abnormal autonomic nervous system physiology +property_value: exactMatch DOID:11465 +property_value: exactMatch http://identifiers.org/mesh/D001342 +property_value: exactMatch http://identifiers.org/snomedct/128123007 +property_value: exactMatch http://identifiers.org/snomedct/15241006 +property_value: excluded_subClassOf MONDO:0001300 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001299 +name: diabetic autonomic neuropathy +def: "Autonomic neuropathy that is caused by diabetes mellitus." [NCIT:P378] +xref: DOID:11503 {source="MONDO:equivalentTo"} +xref: ICD9:337.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27068 {source="DOID:11503", source="MONDO:equivalentTo"} +xref: SCTID:50620007 {source="DOID:11503", source="MONDO:equivalentTo"} +xref: UMLS:C0271686 {source="DOID:11503", source="NCIT:C27068", source="MONDO:equivalentTo"} +is_a: MONDO:0001300 {source="DOID:11503", source="MONDO:Redundant", source="NCIT:C27068"} ! autonomic neuropathy +is_a: MONDO:0006626 {source="DOID:11503", source="MONDO:Redundant", source="NCIT:C27068"} ! diabetic neuropathy +intersection_of: MONDO:0001300 ! autonomic neuropathy +intersection_of: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +property_value: exactMatch DOID:11503 +property_value: exactMatch http://identifiers.org/snomedct/50620007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271686 +property_value: exactMatch NCIT:C27068 + +[Term] +id: MONDO:0001300 +name: autonomic neuropathy +def: "An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities." [NCIT:C27033] +synonym: "autonomic nervous system peripheral neuropathy" EXACT [MONDO:patterns/location] +synonym: "autonomic peripheral neuropathy" EXACT [MONDO:0000604] +synonym: "peripheral neuropathy of autonomic nervous system" EXACT [MONDO:design_pattern] +xref: CSP:2042-2001 {source="DOID:11504"} +xref: CSP:2049-9000 {source="DOID:11504"} +xref: DOID:0060054 {source="MONDO:equivalentTo"} +xref: DOID:11504 {source="MONDO:equivalentTo"} +xref: NCIT:C27033 {source="DOID:11504", source="MONDO:equivalentTo"} +xref: SCTID:277879009 {source="DOID:11504", source="MONDO:equivalentTo"} +xref: UMLS:C0259749 {source="NCIT:C27033", source="DOID:11504", source="MONDO:equivalentTo"} +is_a: MONDO:0001292 {source="DOID:11504", source="MONDO:Redundant"} ! autonomic nervous system disorder +is_a: MONDO:0005244 {source="DOID:0060054", source="MONDO:Redundant", source="NCIT:C27033"} ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_location UBERON:0002410 ! autonomic nervous system +property_value: exactMatch DOID:0060054 +property_value: exactMatch DOID:11504 +property_value: exactMatch http://identifiers.org/snomedct/277879009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0259749 +property_value: exactMatch NCIT:C27033 + +[Term] +id: MONDO:0001302 +name: hypertensive heart disease +def: "Abnormal enlargement of the heart resulting from long-standing hypertension." [NCIT:C4907] +synonym: "hypertensive cardiomegaly" RELATED [] +synonym: "hypertensive cardiopathy" RELATED [] +synonym: "hypertensive cardiovascular disease" RELATED [] +synonym: "hypertensive heart disease" EXACT [] +xref: DOID:11516 {source="MONDO:equivalentTo"} +xref: ICD9:402 {source="DOID:11516"} +xref: ICD9:402.9 {source="DOID:11516"} +xref: NCIT:C4907 {source="MONDO:equivalentTo"} +xref: SCTID:64715009 {source="DOID:11516", source="MONDO:equivalentTo"} +xref: UMLS:C0152105 {source="DOID:11516", source="MONDO:equivalentTo"} +is_a: MONDO:0005267 {source="DOID:11516", source="MONDO:Redundant", source="NCIT:C4907/inferred"} ! heart disorder +intersection_of: MONDO:0005267 ! heart disorder +intersection_of: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +relationship: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +property_value: exactMatch DOID:11516 +property_value: exactMatch http://identifiers.org/snomedct/64715009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152105 +property_value: exactMatch NCIT:C4907 + +[Term] +id: MONDO:0001322 +name: pericardium cancer +def: "A malignant neoplasm involving the pericardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of pericardium" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pericardium" EXACT [DOID:116, MONDO:patterns/cancer, NCIT:C4567] +synonym: "malignant neoplasm of the pericardium" EXACT [NCIT:C4567] +synonym: "malignant pericardial neoplasm" EXACT [NCIT:C4567] +synonym: "malignant pericardial tumor" EXACT [NCIT:C4567] +synonym: "malignant pericardium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of pericardium" EXACT [DOID:116, NCIT:C4567] +synonym: "malignant tumor of the pericardium" EXACT [NCIT:C4567] +synonym: "pericardial tumor" BROAD [DOID:116, NCIT:C4651] +synonym: "pericardium cancer" EXACT [MONDO:patterns/location] +xref: DOID:116 {source="MONDO:equivalentTo"} +xref: NCIT:C4567 {source="DOID:116", source="MONDO:equivalentTo"} +xref: UMLS:C0346609 {source="DOID:116", source="MONDO:equivalentTo", source="NCIT:C4567"} +is_a: MONDO:0001340 {source="DOID:116", source="NCIT:C4567"} ! heart cancer +is_a: MONDO:0021381 {source="MONDO:Redundant", source="NCIT:C4567"} ! neoplasm of pericardium +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002407 ! pericardium +property_value: exactMatch DOID:116 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346609 +property_value: exactMatch NCIT:C4567 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001325 +name: penile cancer +def: "A primary or metastatic malignant neoplasm that affects the penis. Representative examples include penile carcinoma and penile sarcoma." [NCIT:C7547] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:398043"} +synonym: "Ca penis" EXACT [DOID:11615] +synonym: "cancer of penis" EXACT [MONDO:patterns/cancer, Orphanet:398043] +synonym: "malignant neoplasm of body of penis" EXACT [DOID:11615] +synonym: "malignant neoplasm of penis" EXACT [MONDO:patterns/cancer, NCIT:C7547] +synonym: "malignant neoplasm of the penis" EXACT [NCIT:C7547] +synonym: "malignant penile neoplasm" EXACT [NCIT:C7547] +synonym: "malignant penile tumor" EXACT [DOID:11615, NCIT:C7547, Orphanet:398043] +synonym: "malignant penis neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of penis" EXACT [MONDO:0018350, NCIT:C7547] +synonym: "malignant tumor of the penis" EXACT [NCIT:C7547] +synonym: "penile Ca" EXACT [DOID:11615] +synonym: "penile cancer" EXACT [Orphanet:398043] +synonym: "penile neoplasm" BROAD [DOID:11615] +synonym: "penis cancer" EXACT [MONDO:patterns/location] +xref: DOID:11615 {source="MONDO:equivalentTo"} +xref: ICD10CM:C60.0 {source="Orphanet:398043/ntbt", source="Orphanet:398043"} +xref: ICD10CM:C60.1 {source="Orphanet:398043/ntbt", source="Orphanet:398043"} +xref: ICD10CM:C60.2 {source="DOID:11615", source="Orphanet:398043/ntbt", source="Orphanet:398043"} +xref: ICD10CM:C60.8 {source="Orphanet:398043/ntbt", source="Orphanet:398043"} +xref: ICD10CM:C60.9 {source="DOID:11615", source="Orphanet:398043/ntbt", source="Orphanet:398043"} +xref: ICD9:187.3 {source="DOID:11615"} +xref: ICD9:187.4 {source="DOID:11615", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7547 {source="DOID:11615", source="MONDO:equivalentTo"} +xref: Orphanet:398043 {source="MONDO:equivalentTo"} +xref: SCTID:363516004 {source="DOID:11615", source="MONDO:equivalentTo"} +xref: UMLS:CN226091 {source="MONDO:equivalentTo"} +is_a: MONDO:0005836 {source="DOID:11615", source="MONDO:Redundant", source="NCIT:C7547"} ! male reproductive organ cancer +is_a: MONDO:0006895 {source="MONDO:Redundant", source="NCIT:C7547"} ! penile neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000989 ! penis +relationship: has_modifier MONDO:0021136 {source="MONDO:0015931"} ! rare +property_value: exactMatch DOID:11615 +property_value: exactMatch http://identifiers.org/snomedct/363516004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN226091 +property_value: exactMatch NCIT:C7547 +property_value: exactMatch Orphanet:398043 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C60.0 +property_value: narrowMatch https://icd.codes/icd10cm/C60.1 +property_value: narrowMatch https://icd.codes/icd10cm/C60.2 +property_value: narrowMatch https://icd.codes/icd10cm/C60.8 +property_value: narrowMatch https://icd.codes/icd10cm/C60.9 + +[Term] +id: MONDO:0001336 +name: familial hyperlipidemia +def: "An instance of hyperlipidemia (disease) that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "familial hyperlipemia" RELATED [] +synonym: "familial hyperlipoproteinemia" RELATED [DOID:1168] +synonym: "hereditary hyperlipidemia (disease)" EXACT [MONDO:patterns/hereditary] +synonym: "hyperlipemia" BROAD [DOID:1168] +synonym: "hyperlipidaemia" BROAD [DOID:1168] +xref: DOID:1168 {source="MONDO:equivalentTo"} +xref: NCIT:C34707 {source="DOID:1168", source="MONDO:otherHierarchy"} +is_a: MONDO:0002525 {source="DOID:1168", source="MONDO:Redundant"} ! inherited lipid metabolism disorder +is_a: MONDO:0021187 ! hyperlipidemia +intersection_of: MONDO:0021187 ! hyperlipidemia +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:1168 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: relatedMatch NCIT:C34707 + +[Term] +id: MONDO:0001340 +name: heart cancer +def: "A malignant neoplasm involving the heart" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of heart" EXACT [MONDO:patterns/cancer] +synonym: "Cardiac neoplasm, malignant" EXACT [NCIT:C3548] +synonym: "Cardiac tumor" BROAD [DOID:117, NCIT:C3081] +synonym: "heart cancer" EXACT [MONDO:patterns/location, NCIT:C3548] +synonym: "malignant Cardiac neoplasm" EXACT [NCIT:C3548] +synonym: "malignant Cardiac tumor" EXACT [DOID:117, NCIT:C3548] +synonym: "malignant heart neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3548] +synonym: "malignant heart tumor" EXACT [NCIT:C3548] +synonym: "malignant neoplasm of heart" EXACT [DOID:117, MONDO:patterns/cancer, NCIT:C3548] +synonym: "malignant neoplasm of the heart" EXACT [NCIT:C3548] +synonym: "malignant tumor of heart" EXACT [NCIT:C3548] +synonym: "malignant tumor of the heart" EXACT [NCIT:C3548] +synonym: "tumour of heart" BROAD [DOID:117] +xref: DOID:117 {source="MONDO:equivalentTo"} +xref: ICD9:164.1 {source="DOID:117"} +xref: MESH:D006338 {source="DOID:117", source="MONDO:equivalentTo"} +xref: NCIT:C3548 {source="DOID:117", source="MONDO:equivalentTo"} +is_a: MONDO:0002100 {source="DOID:117", source="MONDO:Redundant", source="NCIT:C3548"} ! cardiovascular cancer +is_a: MONDO:0003274 ! thoracic cancer +is_a: MONDO:0021209 {source="MONDO:Redundant", source="NCIT:C3548"} ! heart neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch DOID:117 +property_value: exactMatch http://identifiers.org/mesh/D006338 +property_value: exactMatch NCIT:C3548 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001343 +name: impaired renal function disease +def: "Any disease in which the causes of the disease is a perturbation of the kidney leading to its dysfunction." [MONDO:patterns/disease_by_dysfunctional_structure] +synonym: "disease of kidney" BROAD [MONDO:patterns/disease_by_dysfunctional_structure] +synonym: "kidney disease" BROAD [] +xref: DOID:11705 {source="MONDO:equivalentObsolete"} +xref: ICD10CM:N25 {source="MONDO:equivalentTo"} +xref: ICD9:588.8 {source="DOID:11705"} +xref: ICD9:588.89 {source="DOID:11705"} +xref: ICD9:588.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:197663003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="DOID:11705"} ! kidney disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0002113 ! kidney +relationship: disease_has_basis_in_dysfunction_of UBERON:0002113 ! kidney +property_value: exactMatch http://identifiers.org/snomedct/197663003 +property_value: exactMatch https://icd.codes/icd10cm/N25 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/disease_by_dysfunctional_structure.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0001350 +name: parametrium malignant neoplasm +def: "A malignant neoplasm involving the parametrium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of parametrium" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of parametrium" EXACT [MONDO:patterns/cancer] +synonym: "malignant parametrium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "parametrium cancer" EXACT [MONDO:patterns/location] +xref: DOID:11746 {source="MONDO:equivalentTo"} +xref: ICD9:183.4 {source="DOID:11746", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:448674007 {source="DOID:11746", source="MONDO:equivalentTo"} +xref: UMLS:C0153581 {source="DOID:11746", source="MONDO:equivalentTo"} +is_a: MONDO:0001108 ! broad ligament malignant neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0010391 ! parametrium +relationship: disease_has_location UBERON:0010391 ! parametrium +property_value: exactMatch DOID:11746 +property_value: exactMatch http://identifiers.org/snomedct/448674007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153581 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001351 +name: uterine adnexa cancer +comment: Editor note: TODO add uberon class +xref: DOID:11747 {source="MONDO:equivalentTo"} +xref: ICD9:183 {source="DOID:11747"} +xref: ICD9:183.9 {source="DOID:11747"} +is_a: MONDO:0002715 {source="DOID:11747"} ! uterine cancer +property_value: exactMatch DOID:11747 + +[Term] +id: MONDO:0001358 +name: bronchial disorder +def: "A disease involving the bronchus." [MONDO:patterns/location_top] +synonym: "bronchial disorder" EXACT [] +synonym: "bronchospasm" EXACT [DOID:1176, NCIT:C34439] +synonym: "bronchus disease" EXACT [MONDO:patterns/location] +synonym: "bronchus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of bronchus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of bronchus" EXACT [] +synonym: "disorder of bronchus" EXACT [MONDO:patterns/location_top] +xref: DOID:1176 {source="MONDO:equivalentTo"} +xref: EFO:1002018 {source="MONDO:equivalentTo"} +xref: ICD9:519.19 +xref: MESH:D001982 {source="DOID:1176", source="MONDO:equivalentTo"} +xref: NCIT:C34439 {source="MONDO:equivalentTo"} +xref: SCTID:41427001 {source="DOID:1176", source="MONDO:equivalentTo"} +xref: UMLS:C0006261 {source="DOID:1176", source="MONDO:equivalentTo"} +is_a: MONDO:0000270 {source="DOID:1176", source="MONDO:Redundant"} ! lower respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002185 ! bronchus +relationship: disease_has_location UBERON:0002185 ! bronchus +property_value: exactMatch DOID:1176 +property_value: exactMatch http://identifiers.org/mesh/D001982 +property_value: exactMatch http://identifiers.org/snomedct/41427001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006261 +property_value: exactMatch NCIT:C34439 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001369 +name: chronic laryngitis +def: "Persistent laryngitis usually caused by smoking, heavy alcohol consumption, voice abuse, or gastroesophageal reflux disease. It results in hoarseness and other voice changes." [NCIT:P378] +synonym: "laryngitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:11797 {source="MONDO:equivalentTo"} +xref: ICD10CM:J37.0 {source="DOID:11797", source="MONDO:equivalentTo"} +xref: ICD9:476.0 {source="DOID:11797", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C26975 {source="DOID:11797", source="MONDO:equivalentTo"} +xref: SCTID:29951006 {source="DOID:11797", source="MONDO:equivalentTo"} +xref: UMLS:C0155836 {source="DOID:11797", source="MONDO:equivalentTo", source="NCIT:C26975"} +is_a: MONDO:0002647 {source="DOID:11797", source="MONDO:Redundant", source="NCIT:C26975"} ! laryngitis +intersection_of: MONDO:0002647 ! laryngitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:11797 +property_value: exactMatch http://identifiers.org/snomedct/29951006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155836 +property_value: exactMatch https://icd.codes/icd10cm/J37.0 +property_value: exactMatch NCIT:C26975 + +[Term] +id: MONDO:0001372 +name: bladder neck cancer +def: "A malignant neoplasm involving the neck of urinary bladder." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of neck of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant neck of urinary bladder neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of neck of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of urinary bladder neck" EXACT [DOID:11809] +synonym: "malignant tumor of bladder neck" EXACT [DOID:11809] +synonym: "neck of urinary bladder cancer" EXACT [MONDO:patterns/location] +xref: DOID:11809 {source="MONDO:equivalentTo"} +xref: ICD9:188.5 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11809"} +xref: SCTID:188244007 {source="MONDO:equivalentTo", source="DOID:11809"} +is_a: MONDO:0001187 {source="DOID:11809", source="MONDO:Redundant"} ! urinary bladder cancer +is_a: MONDO:0041154 ! disorder of neck of urinary bladder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001258 ! neck of urinary bladder +property_value: exactMatch DOID:11809 +property_value: exactMatch http://identifiers.org/snomedct/188244007 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001375 +name: bladder trigone cancer +def: "A malignant neoplasm involving the trigone of urinary bladder." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of trigone of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of trigone of urinary bladder" EXACT [DOID:11813, ICD9CM:188.0, MONDO:patterns/cancer] +synonym: "malignant trigone of urinary bladder neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "trigone of urinary bladder cancer" EXACT [MONDO:patterns/location] +xref: DOID:11813 {source="MONDO:equivalentTo"} +xref: ICD9:188.0 {source="DOID:11813", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:188239000 {source="DOID:11813", source="MONDO:equivalentTo"} +xref: UMLS:C0496826 {source="DOID:11813", source="MONDO:equivalentTo"} +is_a: MONDO:0001380 ! bladder dome cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001257 ! trigone of urinary bladder +relationship: disease_has_location UBERON:0001257 ! trigone of urinary bladder +property_value: exactMatch DOID:11813 +property_value: exactMatch http://identifiers.org/snomedct/188239000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496826 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001378 +name: urachus cancer +def: "A malignant neoplasm involving the urachus." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of urachus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of urachus" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of urachus" EXACT [DOID:11817] +synonym: "malignant urachus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "urachus cancer" EXACT [MONDO:patterns/location] +xref: DOID:11817 {source="MONDO:equivalentTo"} +xref: ICD9:188.7 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11817"} +xref: SCTID:363456000 {source="MONDO:equivalentTo", source="DOID:11817"} +xref: UMLS:C0153615 {source="MONDO:equivalentTo", source="DOID:11817"} +is_a: MONDO:0001187 {source="DOID:11817", source="MONDO:Redundant"} ! urinary bladder cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002068 ! urachus +relationship: disease_has_location UBERON:0002068 ! urachus +property_value: exactMatch DOID:11817 +property_value: exactMatch http://identifiers.org/snomedct/363456000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153615 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001379 +name: ureteric orifice cancer +def: "A malignant neoplasm involving the ureteral orifice." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of ureteral orifice" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of ureteral orifice" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of ureteric orifice of urinary bladder" EXACT [DOID:11818] +synonym: "malignant tumor of ureteric orifice" EXACT [DOID:11818] +synonym: "malignant ureteral orifice neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "orifice of the ureter" EXACT [DOID:11818, NCIT:C12337] +synonym: "ureteral orifice cancer" EXACT [MONDO:patterns/location] +xref: DOID:11818 {source="MONDO:equivalentTo"} +xref: ICD9:188.6 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11818"} +xref: NCIT:C12337 {source="MONDO:otherHierarchy", source="DOID:11818"} +xref: SCTID:188245008 {source="MONDO:equivalentTo", source="DOID:11818"} +xref: UMLS:C0153614 {source="MONDO:equivalentTo", source="DOID:11818"} +is_a: MONDO:0001380 ! bladder dome cancer +is_a: MONDO:0008627 {source="DOID:11818"} ! ureter cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0012303 ! ureteral orifice +relationship: disease_has_location UBERON:0012303 ! ureteral orifice +property_value: exactMatch DOID:11818 +property_value: exactMatch http://identifiers.org/snomedct/188245008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153614 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: relatedMatch NCIT:C12337 + +[Term] +id: MONDO:0001380 +name: bladder dome cancer +def: "Cancer of the upper, convex surface of the bladder." [MONDO:cjm] +synonym: "cancer of fundus of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "fundus of urinary bladder cancer" EXACT [MONDO:patterns/location] +synonym: "malignant fundus of urinary bladder neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of apex of urinary bladder" EXACT [DOID:11820] +synonym: "malignant neoplasm of dome of urinary bladder" EXACT [DOID:11820, ICD9CM:188.1] +synonym: "malignant neoplasm of fundus of urinary bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of vault of bladder" EXACT [DOID:11820] +synonym: "superior surface of bladder" EXACT [DOID:11820, NCIT:C12332] +xref: DOID:11820 {source="MONDO:equivalentTo"} +xref: ICD9:188.1 {source="DOID:11820", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C12332 {source="DOID:11820", source="MONDO:otherHierarchy"} +xref: SCTID:188240003 {source="DOID:11820", source="MONDO:equivalentTo"} +xref: UMLS:C0496827 {source="DOID:11820", source="MONDO:equivalentTo"} +is_a: MONDO:0001187 {source="DOID:11820", source="MONDO:Redundant"} ! urinary bladder cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0006082 ! fundus of urinary bladder +relationship: disease_has_location UBERON:0006082 ! fundus of urinary bladder +property_value: exactMatch DOID:11820 +property_value: exactMatch http://identifiers.org/snomedct/188240003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496827 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: relatedMatch NCIT:C12332 + +[Term] +id: MONDO:0001381 +name: bladder lymphoma +def: "A lymphoma that involves the urinary bladder." [MONDO:patterns/location] +synonym: "lymphoma of bladder" EXACT [NCIT:C6164] +synonym: "lymphoma of the bladder" EXACT [NCIT:C6164] +synonym: "lymphoma of the urinary bladder" EXACT [DOID:11821, NCIT:C6164] +synonym: "lymphoma of urinary bladder" EXACT [NCIT:C6164] +synonym: "primary bladder lymphoma" EXACT [NCIT:C6164] +synonym: "urinary bladder lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:11821 {source="MONDO:equivalentTo"} +xref: NCIT:C6164 {source="DOID:11821", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332561 {source="NCIT:C6164", source="DOID:11821", source="MONDO:equivalentTo"} +is_a: MONDO:0001187 {source="DOID:11821", source="NCIT:C6164"} ! urinary bladder cancer +is_a: MONDO:0005062 {source="DOID:11821", source="MONDO:Redundant", source="NCIT:C6164/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:11821 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332561 +property_value: exactMatch NCIT:C6164 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001384 +name: myopia +def: "The condition in which the individual does not see far distances clearly." [NCIT:P378] +synonym: "myopia" EXACT [MONDO:ambiguous] +synonym: "myopia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "near vision" EXACT [DOID:11830] +synonym: "near-sightedness" EXACT [DOID:11830] +synonym: "short-sightedness" EXACT [DOID:11830] +xref: DOID:11830 {source="MONDO:equivalentTo"} +xref: EFO:0003927 {source="DOID:11830", source="MONDO:equivalentObsolete"} +xref: HP:0000545 {source="MONDO:otherHierarchy"} +xref: ICD10CM:H52.1 {source="DOID:11830", source="MONDO:equivalentTo"} +xref: ICD9:367.1 {source="DOID:11830", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009216 {source="DOID:11830", source="MONDO:equivalentTo"} +xref: NCIT:C102533 {source="DOID:11830", source="MONDO:otherHierarchy"} +xref: OMIMPS:160700 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: SCTID:57190000 {source="DOID:11830", source="MONDO:equivalentTo"} +xref: UMLS:C0027092 {source="DOID:11830", source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0004892 {source="DOID:11830", source="MESH:D009216"} ! refractive error +property_value: exactMatch DOID:11830 +property_value: exactMatch http://identifiers.org/mesh/D009216 +property_value: exactMatch http://identifiers.org/snomedct/57190000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027092 +property_value: exactMatch https://icd.codes/icd10cm/H52.1 +property_value: exactMatch https://omim.org/phenotypicSeries/PS160700 +property_value: IAO:0000589 "myopia (disease)" xsd:string +property_value: relatedMatch NCIT:C102533 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0001388 +name: glans penis cancer +def: "A malignant neoplasm involving the glans penis." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of glans penis" EXACT [MONDO:patterns/cancer] +synonym: "glans penis cancer" EXACT [MONDO:patterns/location] +synonym: "malignant glans penis neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of glans penis" EXACT [DOID:11839, ICD9CM:187.2, MONDO:patterns/cancer] +synonym: "malignant tumor of glans penis" EXACT [DOID:11839] +synonym: "malignant tumour of glans penis" EXACT [DOID:11839] +xref: DOID:11839 {source="MONDO:equivalentTo"} +xref: ICD9:187.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11839"} +xref: SCTID:363451005 {source="MONDO:equivalentTo", source="DOID:11839"} +xref: UMLS:C0153599 {source="MONDO:equivalentTo", source="DOID:11839"} +is_a: MONDO:0001325 {source="DOID:11839", source="MONDO:Redundant"} ! penile cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001299 ! glans penis +relationship: disease_has_location UBERON:0001299 ! glans penis +property_value: exactMatch DOID:11839 +property_value: exactMatch http://identifiers.org/snomedct/363451005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153599 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001397 +name: mononeuropathy +def: "Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions." [MESH:D020422] +xref: DOID:1188 {source="MONDO:equivalentTo"} +xref: MESH:D020422 {source="DOID:1188", source="MONDO:equivalentTo"} +xref: SCTID:128189008 {source="DOID:1188", source="MONDO:equivalentTo"} +xref: UMLS:C0494491 {source="DOID:1188", source="MONDO:equivalentTo"} +is_a: MONDO:0005244 {source="DOID:1188"} ! peripheral neuropathy +property_value: exactMatch DOID:1188 +property_value: exactMatch http://identifiers.org/mesh/D020422 +property_value: exactMatch http://identifiers.org/snomedct/128189008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0494491 + +[Term] +id: MONDO:0001398 +name: ureter benign neoplasm +def: "Cancer or tumors of the ureter which may cause obstruction leading to hydroureter, hydronephrosis, and pyelonephritis. hematuria is a common symptom." [MESH:D014516] +synonym: "benign neoplasm of the ureter" EXACT [NCIT:C3617] +synonym: "benign neoplasm of ureter" EXACT [NCIT:C3617] +synonym: "benign tumor of the ureter" EXACT [NCIT:C3617] +synonym: "benign tumor of ureter" EXACT [NCIT:C3617] +synonym: "benign ureter neoplasm" EXACT [NCIT:C3617] +synonym: "benign ureter tumor" EXACT [NCIT:C3617] +synonym: "benign ureteral neoplasm" EXACT [NCIT:C3617] +synonym: "benign ureteral tumor" EXACT [NCIT:C3617] +synonym: "benign ureteric neoplasm" EXACT [NCIT:C3617] +synonym: "ureter benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "ureteral benign neoplasm" RELATED [DOID:11885] +synonym: "ureteral tumor" BROAD [DOID:11885, NCIT:C3427] +xref: DOID:11885 {source="MONDO:equivalentTo"} +xref: ICD9:223.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014516 {source="DOID:11885", source="MONDO:directSiblingOf"} +xref: NCIT:C3617 {source="MONDO:equivalentTo"} +xref: SCTID:92464009 {source="MONDO:equivalentTo"} +is_a: MONDO:0004180 {source="DOID:11885", source="MONDO:Redundant", source="NCIT:C3617"} ! benign urinary system neoplasm +is_a: MONDO:0021111 {source="MONDO:Redundant", source="NCIT:C3617"} ! ureter neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:11885 +property_value: exactMatch http://identifiers.org/snomedct/92464009 +property_value: exactMatch NCIT:C3617 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0001400 +name: schwannoma of ureter +def: "A benign nerve sheath tumor composed of Schwann cells, occurring in the ureter." [NCIT:P378] +synonym: "neurilemmoma of the ureter" EXACT [NCIT:C6162] +synonym: "neurilemmoma of ureter" EXACT [NCIT:C6162] +synonym: "schwannoma of the ureter" EXACT [NCIT:C6162] +synonym: "ureter neurilemmoma" EXACT [NCIT:C6162] +synonym: "ureter schwannoma" EXACT [MONDO:patterns/location] +synonym: "ureteral neurilemmoma" EXACT [NCIT:C6162] +synonym: "ureteral schwannoma" EXACT [DOID:11888, NCIT:C6162] +xref: DOID:11888 {source="MONDO:equivalentTo"} +xref: NCIT:C6162 {source="DOID:11888", source="MONDO:equivalentTo"} +xref: UMLS:C1336877 {source="DOID:11888", source="MONDO:equivalentTo", source="NCIT:C6162"} +is_a: MONDO:0000638 ! benign glioma +is_a: MONDO:0001398 {source="DOID:11888", source="MONDO:Entailed", source="NCIT:C6162"} ! ureter benign neoplasm +is_a: MONDO:0004820 {source="DOID:11888", source="NCIT:C6162"} ! peripheral nerve schwannoma +is_a: MONDO:0056804 ! benign neoplasm of peripheral nervous system +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:11888 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336877 +property_value: exactMatch NCIT:C6162 + +[Term] +id: MONDO:0001402 +name: vaginal cancer +def: "A primary or metastatic malignant neoplasm involving the vagina. Representative examples include carcinomas and sarcomas." [NCIT:C7410] +subset: gard_rare {source="GARD:0009348"} +synonym: "cancer of vagina" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the vagina" EXACT [NCIT:C7410] +synonym: "malignant neoplasm of vagina" EXACT [DOID:119, ICD9CM:184.0, MONDO:patterns/cancer, NCIT:C7410] +synonym: "malignant tumor of the vagina" EXACT [NCIT:C7410] +synonym: "malignant tumor of vagina" EXACT [NCIT:C7410] +synonym: "malignant vagina neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7410] +synonym: "malignant vagina tumor" EXACT [NCIT:C7410] +synonym: "malignant vaginal neoplasm" EXACT [NCIT:C7410] +synonym: "malignant vaginal tumor" EXACT [DOID:119, NCIT:C7410] +synonym: "vagina cancer" EXACT [MONDO:patterns/location] +synonym: "vagina neoplasm" BROAD [DOID:119] +synonym: "vaginal tumor" BROAD [DOID:119, NCIT:C3437] +xref: DOID:119 {source="MONDO:equivalentTo"} +xref: GARD:0009348 {source="MONDO:equivalentTo"} +xref: ICD9:184.0 {source="DOID:119", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014625 {source="DOID:119", source="MONDO:equivalentTo"} +xref: NCIT:C7410 {source="DOID:119", source="MONDO:equivalentTo"} +xref: SCTID:363445000 {source="DOID:119", source="MONDO:equivalentTo"} +is_a: MONDO:0001416 {source="DOID:119", source="MONDO:Redundant", source="NCIT:C7410"} ! female reproductive organ cancer +is_a: MONDO:0021050 {source="MONDO:Redundant", source="NCIT:C7410"} ! vaginal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch DOID:119 +property_value: exactMatch http://identifiers.org/mesh/D014625 +property_value: exactMatch http://identifiers.org/snomedct/363445000 +property_value: exactMatch NCIT:C7410 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9348/vaginal-cancer xsd:anyURI {source="GARD:0009348"} + +[Term] +id: MONDO:0001403 +name: labium majus cancer +def: "A malignant neoplasm involving the labium majora." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of labium majora" EXACT [MONDO:patterns/cancer] +synonym: "labium majora cancer" EXACT [MONDO:patterns/location] +synonym: "malignant labia majora neoplasm" EXACT [NCIT:C7638] +synonym: "malignant labia majora tumor" EXACT [NCIT:C7638] +synonym: "malignant labium majora neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of labia majora" EXACT [DOID:11905, ICD9CM:184.1, NCIT:C7638] +synonym: "malignant neoplasm of labium majora" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the labia majora" EXACT [NCIT:C7638] +synonym: "malignant tumor of labia majora" EXACT [DOID:11905, NCIT:C7638] +synonym: "malignant tumor of the labia majora" EXACT [NCIT:C7638] +xref: DOID:11905 {source="MONDO:equivalentTo"} +xref: ICD9:184.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11905"} +xref: NCIT:C7638 {source="MONDO:equivalentTo", source="DOID:11905"} +xref: SCTID:363446004 {source="MONDO:equivalentTo", source="DOID:11905"} +xref: UMLS:C0496814 {source="MONDO:equivalentTo", source="DOID:11905", source="NCIT:C7638"} +is_a: MONDO:0001528 {source="DOID:11905", source="MONDO:Redundant", source="NCIT:C7638"} ! vulva cancer +is_a: MONDO:0002898 {source="DOID:11905", source="MONDO:Entailed", source="MONDO:Redundant"} ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004085 ! labium majora +relationship: disease_has_location UBERON:0004085 ! labium majora +property_value: exactMatch DOID:11905 +property_value: exactMatch http://identifiers.org/snomedct/363446004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496814 +property_value: exactMatch NCIT:C7638 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001406 +name: peripheral nervous system neoplasm +def: "A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths." [NCIT:C3321] +synonym: "CNS-excluded nervous sys. cancer" NARROW [NCIT:C3321] +synonym: "neoplasm of peripheral nerve" EXACT [NCIT:C3321] +synonym: "neoplasm of peripheral nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C3321] +synonym: "neoplasm of PNS" EXACT [NCIT:C3321] +synonym: "neoplasm of the peripheral nerve" EXACT [NCIT:C3321] +synonym: "neoplasm of the peripheral nervous system" EXACT [NCIT:C3321] +synonym: "neoplasm of the PNS" EXACT [NCIT:C3321] +synonym: "neoplasms, peripheral nervous system" EXACT [NCIT:C3321] +synonym: "neoplasms, PNS" EXACT [NCIT:C3321] +synonym: "nerve sheath neoplasm" NARROW [DOID:1192] +synonym: "nerve sheath tumors" NARROW [DOID:1192] +synonym: "peripheral nerve neoplasm" EXACT [NCIT:C3321] +synonym: "peripheral nerve tumor" EXACT [NCIT:C3321] +synonym: "peripheral nervous system neoplasm" EXACT [NCIT:C3321] +synonym: "peripheral nervous system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "peripheral nervous system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3321] +synonym: "PNS neoplasm" EXACT [NCIT:C3321] +synonym: "PNS neoplasms" EXACT [NCIT:C3321] +synonym: "PNS tumor" EXACT [NCIT:C3321] +synonym: "tumor of peripheral nerve" EXACT [NCIT:C3321] +synonym: "tumor of peripheral nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C3321] +synonym: "tumor of PNS" EXACT [DOID:1192, NCIT:C3321] +synonym: "tumor of the peripheral nerve" EXACT [NCIT:C3321] +synonym: "tumor of the peripheral nervous system" EXACT [NCIT:C3321] +synonym: "tumor of the PNS" EXACT [NCIT:C3321] +xref: DOID:1192 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010524 {source="MONDO:equivalentTo", source="DOID:1192"} +xref: NCIT:C3321 {source="MONDO:equivalentTo", source="DOID:1192"} +xref: ONCOTREE:PNS {source="MONDO:equivalentTo"} +xref: SCTID:126980002 {source="MONDO:equivalentTo", source="DOID:1192"} +xref: UMLS:C0031118 {source="MONDO:equivalentTo", source="NCIT:C3321", source="DOID:1192"} +is_a: MONDO:0003620 {source="MESH:D010524", source="MONDO:Redundant", source="NCIT:C3321"} ! peripheral nervous system disorder +is_a: MONDO:0021248 {source="MONDO:Redundant", source="NCIT:C3321"} ! nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000010 ! peripheral nervous system +property_value: exactMatch DOID:1192 +property_value: exactMatch http://identifiers.org/mesh/D010524 +property_value: exactMatch http://identifiers.org/snomedct/126980002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031118 +property_value: exactMatch NCIT:C3321 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001407 +name: tracheal cancer +def: "A malignant neoplasm involving the trachea" [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca trachea" EXACT [DOID:11920] +synonym: "cancer of trachea" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the trachea" EXACT [NCIT:C9346] +synonym: "malignant neoplasm of trachea" EXACT [DOID:11920, MONDO:patterns/cancer, MTH:NOCODE, NCIT:C9346] +synonym: "malignant trachea neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9346] +synonym: "malignant trachea tumor" EXACT [NCIT:C9346] +synonym: "malignant tracheal neoplasm" EXACT [NCIT:C9346] +synonym: "malignant tracheal tumor" EXACT [DOID:11920, NCIT:C9346] +synonym: "malignant tumor of the trachea" EXACT [NCIT:C9346] +synonym: "malignant tumor of trachea" EXACT [NCIT:C9346] +synonym: "trachea cancer" EXACT [MONDO:patterns/location] +synonym: "tracheal neoplasm" BROAD [DOID:11920] +xref: DOID:11920 {source="MONDO:equivalentTo"} +xref: ICD10CM:C33 {source="DOID:11920", source="MONDO:equivalentTo"} +xref: ICD9:162.0 {source="DOID:11920", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9346 {source="DOID:11920", source="MONDO:equivalentTo"} +xref: SCTID:363432004 {source="DOID:11920", source="MONDO:equivalentTo"} +xref: UMLS:C0153489 {source="DOID:11920", source="NCIT:C9346", source="MONDO:equivalentTo"} +is_a: MONDO:0000376 {source="DOID:11920", source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0021210 {source="MONDO:Redundant", source="NCIT:C9346"} ! trachea neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch DOID:11920 +property_value: exactMatch http://identifiers.org/snomedct/363432004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153489 +property_value: exactMatch https://icd.codes/icd10cm/C33 +property_value: exactMatch NCIT:C9346 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001409 +name: esophagitis +def: "An acute or chronic inflammatory disease affecting the esophageal wall." [MONDO:cjm, NCIT:C9224] +synonym: "acute esophagitis" NARROW [DOID:11963] +synonym: "esophagitis" EXACT [MONDO:ambiguous] +synonym: "esophagitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "esophagus inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of esophagus" EXACT [] +xref: DOID:11963 {source="MONDO:equivalentTo"} +xref: HP:0100633 {source="MONDO:equivalentTo", source="MONDO:otherHierarchy"} +xref: ICD9:530.1 {source="DOID:11963"} +xref: ICD9:530.10 {source="DOID:11963"} +xref: ICD9:530.12 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D004941 {source="DOID:11963", source="MONDO:equivalentTo"} +xref: NCIT:C9224 {source="DOID:11963", source="MONDO:equivalentTo"} +xref: SCTID:16761005 {source="DOID:11963", source="MONDO:equivalentTo"} +xref: UMLS:C0014868 {source="DOID:11963", source="NCIT:C9224", source="MONDO:equivalentTo"} +xref: UMLS:C0149882 {source="MONDO:equivalentTo"} +is_a: MONDO:0003749 {source="DOID:11963", source="MESH:D004941", source="MONDO:Redundant", source="NCIT:C9224/inferred"} ! esophageal disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001043 ! esophagus +relationship: disease_has_inflammation_site UBERON:0001043 ! esophagus +property_value: exactMatch DOID:11963 +property_value: exactMatch http://identifiers.org/mesh/D004941 +property_value: exactMatch http://identifiers.org/snomedct/16761005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014868 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149882 +property_value: exactMatch NCIT:C9224 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "esophagitis (disease)" xsd:string + +[Term] +id: MONDO:0001416 +name: female reproductive organ cancer +def: "A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma." [NCIT:C4913] +synonym: "cancer of female reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "female reproductive cancer" EXACT [DOID:120, NCIT:C4913] +synonym: "female reproductive organ cancer" EXACT [MONDO:patterns/location] +synonym: "gynecologic cancer" EXACT [NCIT:C4913] +synonym: "malignant female reproductive organ neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant female reproductive system neoplasm" EXACT [NCIT:C4913] +synonym: "malignant female reproductive system tumor" EXACT [NCIT:C4913] +synonym: "malignant gynecologic neoplasm" EXACT [NCIT:C4913] +synonym: "malignant gynecologic tumor" EXACT [DOID:120, NCIT:C4913] +synonym: "malignant neoplasm of female genital organ" EXACT [DOID:120] +synonym: "malignant neoplasm of female reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of female reproductive system" EXACT [NCIT:C4913] +synonym: "malignant neoplasm of the female reproductive system" EXACT [NCIT:C4913] +synonym: "malignant tumor of female reproductive system" EXACT [NCIT:C4913] +synonym: "malignant tumor of the female reproductive system" EXACT [NCIT:C4913] +xref: DOID:120 {source="MONDO:equivalentTo"} +xref: ICD10CM:C51-C58 {source="MONDO:equivalentTo"} +xref: ICD9:184 {source="DOID:120"} +xref: NCIT:C4913 {source="MONDO:equivalentTo", source="DOID:120"} +xref: SCTID:126907002 {source="MONDO:equivalentTo", source="DOID:120"} +is_a: MONDO:0002149 {source="DOID:120", source="MONDO:Redundant", source="NCIT:C4913"} ! reproductive system cancer +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C4913"} ! female reproductive system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003134 ! female reproductive organ +relationship: disease_has_location UBERON:0003134 ! female reproductive organ +property_value: exactMatch DOID:120 +property_value: exactMatch http://identifiers.org/snomedct/126907002 +property_value: exactMatch https://icd.codes/icd10cm/C51-C58 +property_value: exactMatch NCIT:C4913 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001417 +name: tracheal lymphoma +def: "A rare lymphoma that arises from the trachea. Signs and symptoms include dyspnea, cough, wheezing, and stridor." [NCIT:C6248] +synonym: "lymphoma of the trachea" EXACT [DOID:12001, NCIT:C6248] +synonym: "lymphoma of trachea" EXACT [DOID:12001, NCIT:C6248] +synonym: "primary tracheal lymphoma" EXACT [NCIT:C6248] +synonym: "trachea lymphoma" EXACT [MONDO:patterns/location] +synonym: "tracheal lymphoma" EXACT [NCIT:C6248] +xref: DOID:12001 {source="MONDO:equivalentTo"} +xref: NCIT:C6248 {source="MONDO:equivalentTo", source="DOID:12001", source="MONDO:exact-label-match"} +xref: UMLS:C1336773 {source="MONDO:equivalentTo", source="NCIT:C6248", source="DOID:12001"} +is_a: MONDO:0001407 {source="DOID:12001", source="NCIT:C6248"} ! tracheal cancer +is_a: MONDO:0005062 {source="DOID:12001", source="MONDO:Redundant", source="NCIT:C6248/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch DOID:12001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336773 +property_value: exactMatch NCIT:C6248 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001419 +name: trachea squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the mucosal lining of the trachea. It usually grows as an intraluminal mass and later invades extraluminal structures. The majority of patients present with hemoptysis, coughing, dyspnea, or stridor." [NCIT:P378] +synonym: "epidermoid carcinoma of the trachea" EXACT [NCIT:C4448] +synonym: "epidermoid carcinoma of trachea" EXACT [NCIT:C4448] +synonym: "squamous cell carcinoma of the trachea" EXACT [NCIT:C4448] +synonym: "squamous cell carcinoma of trachea" EXACT [DOID:12003, NCIT:C4448] +synonym: "trachea epidermoid carcinoma" EXACT [NCIT:C4448] +synonym: "trachea squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4448] +synonym: "tracheal epidermoid carcinoma" EXACT [DOID:12003, NCIT:C4448] +synonym: "tracheal squamous cell carcinoma" EXACT [NCIT:C4448] +xref: DOID:12003 {source="MONDO:equivalentTo"} +xref: EFO:1000600 {source="MONDO:equivalentTo"} +xref: NCIT:C4448 {source="MONDO:equivalentTo", source="EFO:1000600", source="DOID:12003"} +xref: SCTID:254620000 {source="MONDO:equivalentTo", source="DOID:12003"} +xref: UMLS:C0345946 {source="MONDO:equivalentTo", source="DOID:12003", source="NCIT:C4448"} +is_a: MONDO:0003184 {source="DOID:12003", source="MONDO:Redundant", source="NCIT:C4448"} ! trachea carcinoma +is_a: MONDO:0005096 {source="DOID:12003", source="EFO:1000600", source="MONDO:Redundant", source="NCIT:C4448"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch DOID:12003 +property_value: exactMatch http://identifiers.org/snomedct/254620000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345946 +property_value: exactMatch NCIT:C4448 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0001420 +name: trigeminal nerve neoplasm +def: "Benign and malignant neoplasms which arise from or metastasize to the trigeminal or fifth cranial nerve which provides sensory innervation to the face, oral cavity and sinuses and the muscles of mastication. Clinical features may include facial pain or sensory loss or weakness of jaw closure." [NCIT:C5122] +synonym: "cranial nerve V neoplasms" EXACT [NCIT:C5122] +synonym: "cranial nerve V tumors" EXACT [NCIT:C5122] +synonym: "fifth cranial nerve neoplasm" EXACT [NCIT:C5122] +synonym: "fifth cranial nerve tumor" EXACT [NCIT:C5122] +synonym: "neoplasm of fifth cranial nerve" EXACT [NCIT:C5122] +synonym: "neoplasm of the fifth cranial nerve" EXACT [NCIT:C5122] +synonym: "neoplasm of the trigeminal nerve" EXACT [NCIT:C5122] +synonym: "neoplasm of trigeminal nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5122] +synonym: "neoplasms, cranial nerve V" EXACT [NCIT:C5122] +synonym: "trigeminal nerve neoplasm" EXACT [NCIT:C5122] +synonym: "trigeminal nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "trigeminal nerve neoplasms" EXACT [NCIT:C5122] +synonym: "trigeminal nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5122] +synonym: "trigeminal nerve tumors" EXACT [NCIT:C5122] +synonym: "tumor of fifth cranial nerve" EXACT [NCIT:C5122] +synonym: "tumor of the fifth cranial nerve" EXACT [NCIT:C5122] +synonym: "tumor of the trigeminal nerve" EXACT [NCIT:C5122] +synonym: "tumor of trigeminal nerve" EXACT [DOID:1201, MONDO:patterns/neoplasm, NCIT:C5122] +synonym: "tumors, cranial nerve V" EXACT [NCIT:C5122] +xref: DOID:1201 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5122 {source="DOID:1201", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126971002 {source="DOID:1201", source="MONDO:equivalentTo"} +xref: UMLS:C1263897 {source="DOID:1201", source="NCIT:C5122", source="MONDO:equivalentTo"} +is_a: MONDO:0002633 {source="DOID:1201", source="MONDO:Redundant", source="NCIT:C5122"} ! cranial nerve neoplasm +is_a: MONDO:0003543 ! trigeminal nerve disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001645 ! trigeminal nerve +property_value: exactMatch DOID:1201 +property_value: exactMatch http://identifiers.org/snomedct/126971002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263897 +property_value: exactMatch NCIT:C5122 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001421 +name: frontal lobe neoplasm +def: "A neoplasm involving a frontal lobe." [MONDO:patterns/neoplasm] +synonym: "frontal lobe neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "frontal lobe tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "malignant neoplasm of frontal lobe" NARROW [DOID:12016] +synonym: "neoplasm of frontal lobe" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the frontal lobe" EXACT [NCIT:C5572] +synonym: "tumor of frontal lobe" EXACT [DOID:12016, MONDO:patterns/neoplasm, NCIT:C5572] +synonym: "tumor of the frontal lobe" EXACT [NCIT:C5572] +xref: DOID:12016 {source="MONDO:equivalentTo"} +xref: ICD9:191.1 {source="DOID:12016"} +xref: NCIT:C5572 {source="MONDO:equivalentTo", source="DOID:12016"} +xref: SCTID:126954003 {source="MONDO:equivalentTo", source="DOID:12016"} +xref: UMLS:C1263886 {source="NCIT:C5572", source="MONDO:equivalentTo", source="DOID:12016"} +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C5572"} ! neoplasm of cerebral hemisphere +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0016525 ! frontal lobe +relationship: disease_has_location UBERON:0016525 ! frontal lobe +property_value: exactMatch DOID:12016 +property_value: exactMatch http://identifiers.org/snomedct/126954003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263886 +property_value: exactMatch NCIT:C5572 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001423 +name: drug-induced mental disorder +xref: DOID:1203 {source="MONDO:equivalentTo"} +xref: ICD9:292.8 {source="DOID:1203"} +xref: ICD9:292.89 {source="DOID:1203"} +is_a: MONDO:0005084 ! mental disorder +intersection_of: MONDO:0005084 ! mental disorder +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch DOID:1203 +property_value: excluded_subClassOf MONDO:0004630 {source="DOID:1203"} + +[Term] +id: MONDO:0001433 +name: vaginal disorder +def: "A non-neoplastic or neoplastic disorder that affects the vagina. Representative examples include vaginal infection, vaginal polyp, and vaginal squamous cell carcinoma." [NCIT:P378] +synonym: "disease of vagina" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vagina" EXACT [] +synonym: "disorder of vagina" EXACT [MONDO:patterns/location_top] +synonym: "vagina disease" EXACT [MONDO:patterns/location] +synonym: "vagina disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vaginal disease" EXACT [NCIT:C26910] +synonym: "vaginal disorder" EXACT [NCIT:C26910] +xref: DOID:121 {source="MONDO:equivalentTo"} +xref: MESH:D014623 {source="MONDO:equivalentTo", source="DOID:121"} +xref: NCIT:C26910 {source="MONDO:equivalentTo", source="DOID:121"} +xref: SCTID:25658005 {source="MONDO:equivalentTo", source="DOID:121"} +xref: UMLS:C0042251 {source="MONDO:equivalentTo", source="DOID:121", source="NCIT:C26910"} +is_a: MONDO:0002263 {source="DOID:121", source="MESH:D014623", source="MONDO:Redundant", source="NCIT:C26910"} ! female reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000996 ! vagina +relationship: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch DOID:121 +property_value: exactMatch http://identifiers.org/mesh/D014623 +property_value: exactMatch http://identifiers.org/snomedct/25658005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042251 +property_value: exactMatch NCIT:C26910 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001459 +name: radial neuropathy +def: "Disease involving the radial nerve. Clinical features include weakness of elbow extension, elbow flexion, supination of the forearm, wrist and finger extension, and thumb abduction. Sensation may be impaired over regions of the dorsal forearm. Common sites of compression or traumatic injury include the axilla and radial groove of the humerus." [MESH:D020425] +synonym: "peripheral neuropathy of radial nerve" EXACT [MONDO:design_pattern] +synonym: "radial nerve peripheral neuropathy" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:12171 {source="MONDO:equivalentTo"} +xref: MESH:D020425 {source="DOID:12171", source="MONDO:equivalentTo"} +xref: SCTID:16644004 {source="DOID:12171", source="MONDO:equivalentTo"} +xref: UMLS:C0748226 {source="DOID:12171", source="MONDO:equivalentTo"} +is_a: MONDO:0001397 {source="DOID:12171", source="MESH:D020425"} ! mononeuropathy +is_a: MONDO:0006683 ! brachial plexus neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_location UBERON:0001492 ! radial nerve +relationship: disease_has_location UBERON:0001492 ! radial nerve +property_value: exactMatch DOID:12171 +property_value: exactMatch http://identifiers.org/mesh/D020425 +property_value: exactMatch http://identifiers.org/snomedct/16644004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0748226 + +[Term] +id: MONDO:0001462 +name: descending colon cancer +def: "A malignant neoplasm involving the descending colon." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca descending colon" EXACT [DOID:12190] +synonym: "cancer of descending colon" EXACT [MONDO:patterns/cancer] +synonym: "descending colon cancer" EXACT [MONDO:patterns/location] +synonym: "malignant descending colon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of descending colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of left colon" EXACT [DOID:12190] +synonym: "malignant tumor of descending colon" EXACT [DOID:12190] +xref: DOID:12190 {source="MONDO:equivalentTo"} +xref: ICD9:153.2 {source="DOID:12190", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363409003 {source="DOID:12190", source="MONDO:equivalentTo"} +xref: UMLS:C0153435 {source="DOID:12190", source="MONDO:equivalentTo"} +is_a: MONDO:0021063 {source="DOID:12190", source="MONDO:Redundant"} ! malignant colon neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001158 ! descending colon +relationship: disease_has_location UBERON:0001158 ! descending colon +property_value: exactMatch DOID:12190 +property_value: exactMatch http://identifiers.org/snomedct/363409003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153435 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001464 +name: sigmoid colon cancer +def: "A malignant neoplasm involving the sigmoid colon." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca sigmoid colon" EXACT [DOID:12192] +synonym: "cancer of sigmoid colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sigmoid colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant sigmoid colon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of sigmoid colon" EXACT [DOID:12192] +synonym: "sigmoid colon cancer" EXACT [MONDO:patterns/location] +xref: DOID:12192 {source="MONDO:equivalentTo"} +xref: ICD9:153.3 {source="DOID:12192", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363410008 {source="DOID:12192", source="MONDO:equivalentTo"} +xref: UMLS:C0153436 {source="DOID:12192", source="MONDO:equivalentTo"} +is_a: MONDO:0006971 {source="MONDO:Redundant"} ! sigmoid neoplasm +is_a: MONDO:0021063 {source="DOID:12192", source="MONDO:Redundant"} ! malignant colon neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001159 ! sigmoid colon +property_value: exactMatch DOID:12192 +property_value: exactMatch http://identifiers.org/snomedct/363410008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153436 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001470 +name: anal margin squamous cell carcinoma +def: "A squamous cell carcinoma arising from the perianal skin." [NCIT:C6925] +synonym: "anal margin squamous cell carcinoma" EXACT [NCIT:C6925] +synonym: "perianal skin squamous cell carcinoma" EXACT [DOID:12239, MONDO:patterns/location, NCIT:C6925] +synonym: "squamous cell carcinoma of anal margin" EXACT [DOID:12239, NCIT:C6925] +synonym: "squamous cell carcinoma of the anal margin" EXACT [NCIT:C6925] +xref: DOID:12239 {source="MONDO:equivalentTo"} +xref: ICD9:173.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6925 {source="DOID:12239", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:255084004 {source="DOID:12239", source="MONDO:equivalentTo"} +xref: UMLS:C1412037 {source="DOID:12239", source="MONDO:equivalentTo", source="NCIT:C6925"} +is_a: MONDO:0002529 {source="DOID:12239", source="MONDO:Redundant"} ! skin squamous cell carcinoma +is_a: MONDO:0002941 {source="DOID:12239", source="MONDO:Redundant", source="NCIT:C6925"} ! anal margin carcinoma +is_a: MONDO:0006082 {source="MONDO:Redundant", source="NCIT:C6925"} ! anal squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0012336 ! perianal skin +property_value: exactMatch DOID:12239 +property_value: exactMatch http://identifiers.org/snomedct/255084004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1412037 +property_value: exactMatch NCIT:C6925 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0001474 +name: chronic salpingo-oophoritis +def: "Chronic form of salpingo-oophoritis." [MONDO:patterns/chronic] +synonym: "chronic salpingitis and oophoritis" EXACT [DOID:12265, ICD9CM:614.1] +synonym: "chronic salpingitis/oophoritis" EXACT [DOID:12265] +synonym: "chronic salpingo-oophoritis" EXACT [DOID:12265] +synonym: "salpingo-oophoritis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:12265 {source="MONDO:equivalentTo"} +xref: ICD9:614.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12265"} +xref: SCTID:198142001 {source="MONDO:equivalentTo", source="DOID:12265"} +xref: UMLS:C0156328 {source="MONDO:equivalentTo", source="DOID:12265"} +is_a: MONDO:0001172 {source="DOID:12265", source="MONDO:Redundant"} ! salpingo-oophoritis +is_a: MONDO:0003617 {source="MONDO:Redundant"} ! chronic salpingitis +intersection_of: MONDO:0001172 ! salpingo-oophoritis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:12265 +property_value: exactMatch http://identifiers.org/snomedct/198142001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0156328 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0001487 +name: intrahepatic bile duct cancer +def: "A cancer that involves the intrahepatic bile duct." [MONDO:patterns/location] +synonym: "Ca intrahepatic bile ducts" EXACT [DOID:12298] +synonym: "cancer of intrahepatic bile duct" EXACT [MONDO:patterns/cancer] +synonym: "malignant intrahepatic bile duct neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of intrahepatic bile duct" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of intrahepatic bile ducts" EXACT [DOID:12298, ICD9CM:155.1] +synonym: "malignant neoplasm of intrahepatic biliary passages" EXACT [DOID:12298] +xref: DOID:12298 {source="MONDO:equivalentTo"} +xref: ICD9:155.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12298"} +xref: SCTID:187777008 {source="MONDO:equivalentTo", source="DOID:12298"} +xref: UMLS:C0546835 {source="MONDO:equivalentTo", source="DOID:12298"} +is_a: MONDO:0003059 ! bile duct cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003704 ! intrahepatic bile duct +relationship: disease_has_location UBERON:0003704 ! intrahepatic bile duct +property_value: exactMatch DOID:12298 +property_value: exactMatch http://identifiers.org/snomedct/187777008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0546835 +property_value: excluded_subClassOf MONDO:0005411 {source="DOID:12298"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001499 +name: retroperitoneal lymphoma +def: "A lymphoma that involves the retroperitoneal space." [MONDO:patterns/location] +synonym: "lymphoma of retroperitoneal space" EXACT [MONDO:design_pattern] +synonym: "primary retroperitoneal lymphoma" EXACT [NCIT:C7353] +synonym: "retroperitoneal lymphoma" EXACT [NCIT:C7353] +synonym: "retroperitoneal space lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:12339 {source="MONDO:equivalentTo"} +xref: NCIT:C7353 {source="DOID:12339", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:422853008 {source="MONDO:equivalentTo"} +xref: UMLS:C1335779 {source="DOID:12339", source="NCIT:C7353", source="MONDO:equivalentTo"} +is_a: MONDO:0005062 {source="MONDO:Redundant", source="NCIT:C7353/inferred"} ! lymphoma +is_a: MONDO:0005941 {source="DOID:12339", source="NCIT:C7353"} ! retroperitoneal cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0003693 ! retroperitoneal space +property_value: exactMatch DOID:12339 +property_value: exactMatch http://identifiers.org/snomedct/422853008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335779 +property_value: exactMatch NCIT:C7353 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001502 +name: retroperitoneum carcinoma +def: "A carcinoma that arises from epithelial cells of the retroperitoneal space." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of retroperitoneal space" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of retroperitoneum" EXACT [DOID:12342, NCIT:C7352] +synonym: "carcinoma of the retroperitoneum" EXACT [DOID:12342, NCIT:C7352] +synonym: "retroperitoneal cancer" BROAD [NCIT:C7352] +synonym: "retroperitoneal carcinoma" EXACT [NCIT:C7352] +synonym: "retroperitoneal space carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:12342 {source="MONDO:equivalentTo"} +xref: NCIT:C7352 {source="MONDO:equivalentTo", source="DOID:12342"} +xref: UMLS:C0948749 {source="NCIT:C7352", source="MONDO:equivalentTo", source="DOID:12342"} +is_a: MONDO:0004993 {source="DOID:12342", source="MONDO:Redundant", source="NCIT:C7352"} ! carcinoma +is_a: MONDO:0005941 {source="DOID:12342", source="MONDO:Redundant", source="NCIT:C7352"} ! retroperitoneal cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003693 ! retroperitoneal space +property_value: exactMatch DOID:12342 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0948749 +property_value: exactMatch NCIT:C7352 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0001505 +name: alcoholic hepatitis +def: "Acute hepatitis resulting from ingestion of alcohol." [NCIT:P378] +synonym: "acute alcoholic Hepatitis" EXACT [DOID:12351, NCIT:C34352] +synonym: "acute alcoholic hepatitis" EXACT [DOID:12351, ICD9CM:571.1] +synonym: "acute alcoholic liver disease" EXACT [DOID:12351] +synonym: "alcoholic Hepatitis" EXACT [DOID:12351, NCIT:C34684] +synonym: "alcoholic hepatitis" EXACT [DOID:12351] +xref: CSP:1754-6978 {source="DOID:12351"} +xref: DOID:12351 {source="MONDO:equivalentTo"} +xref: ICD10CM:K70.1 {source="MONDO:equivalentTo"} +xref: ICD9:571.1 {source="DOID:12351"} +xref: MESH:D006519 {source="MONDO:equivalentTo"} +xref: NCIT:C34684 {source="MONDO:equivalentTo"} +xref: SCTID:235875008 {source="MONDO:equivalentTo"} +xref: UMLS:C0001306 {source="MONDO:equivalentTo", source="DOID:12351"} +is_a: MONDO:0002251 {source="DOID:12351", source="MESH:D006519", source="MONDO:Redundant", source="NCIT:C34684"} ! hepatitis +is_a: MONDO:0043693 {source="MESH:D006519", source="MONDO:Redundant", source="NCIT:C34684"} ! alcoholic liver diseases +intersection_of: MONDO:0002251 ! hepatitis +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:12351 +property_value: exactMatch http://identifiers.org/mesh/D006519 +property_value: exactMatch http://identifiers.org/snomedct/235875008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001306 +property_value: exactMatch https://icd.codes/icd10cm/K70.1 +property_value: exactMatch NCIT:C34684 + +[Term] +id: MONDO:0001506 +name: prostatocystitis +xref: DOID:12355 {source="MONDO:equivalentTo"} +xref: ICD10CM:N41.3 {source="MONDO:equivalentTo", source="DOID:12355"} +xref: ICD9:601.3 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12355"} +xref: SCTID:67685000 {source="MONDO:equivalentTo", source="DOID:12355"} +xref: UMLS:C0156291 {source="MONDO:equivalentTo", source="DOID:12355"} +is_a: MONDO:0005280 ! prostatitis +is_a: MONDO:0006032 {source="DOID:12355", source="MONDO:Redundant"} ! cystitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001255 ! urinary bladder +intersection_of: disease_has_inflammation_site UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:12355 +property_value: exactMatch http://identifiers.org/snomedct/67685000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0156291 +property_value: exactMatch https://icd.codes/icd10cm/N41.3 + +[Term] +id: MONDO:0001507 +name: viral labyrinthitis +def: "An labyrinthitis caused by infection with Viruses." [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "epidemic vertigo" EXACT [DOID:12357, ICD9CM:078.81] +synonym: "epidemic vertigo (finding)" EXACT [DOID:12357] +synonym: "Viruses caused labyrinthitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses labyrinthitis" EXACT [] +xref: DOID:12357 {source="MONDO:equivalentTo"} +xref: ICD9:386.35 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12357"} +xref: SCTID:409711008 {source="MONDO:equivalentTo", source="DOID:12357"} +xref: UMLS:C0155508 {source="MONDO:equivalentTo", source="DOID:12357"} +is_a: MONDO:0002008 {source="DOID:12357", source="DOID:12357/inferred", source="MONDO:Redundant"} ! labyrinthitis +is_a: MONDO:0021666 ! ear infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0001846 ! internal ear +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch DOID:12357 +property_value: exactMatch http://identifiers.org/snomedct/409711008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155508 + +[Term] +id: MONDO:0001517 +name: dysentery +def: "Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration." [MESH:D004403] +synonym: "diarrheal disease, infectious" EXACT [MESH:D004403] +synonym: "dysenteric diarrhea" EXACT [] +synonym: "infectious diarrhea" EXACT [DOID:12384, ICD9CM:009.2] +synonym: "infectious diarrheal disease" EXACT [MESH:D004403] +synonym: "infectious diarrheal diseases" EXACT [MESH:D004403] +synonym: "infective diarrhea" EXACT [] +xref: DOID:12384 {source="MONDO:equivalentTo"} +xref: EFO:1001869 {source="MONDO:equivalentTo"} +xref: ICD9:009.2 {source="DOID:12384"} +xref: MESH:D004403 {source="MONDO:equivalentTo", source="DOID:12384"} +xref: SCTID:111939009 {source="MONDO:equivalentTo", source="DOID:12384"} +xref: SCTID:19213003 {source="MONDO:equivalentTo", source="DOID:12384"} +xref: UMLS:C0013369 {source="MONDO:equivalentTo", source="DOID:12384"} +is_a: MONDO:0000252 ! inflammatory diarrhea +is_a: MONDO:0000257 ! acute diarrhea +is_a: MONDO:0000916 {source="DOID:12384"} ! intestinal infectious disease +intersection_of: MONDO:0001673 ! diarrheal disease +intersection_of: MONDO:0005550 ! infectious disease +relationship: disease_has_feature HP:0025085 {source="Wikipedia:Dysentery"} ! Bloody diarrhea +property_value: exactMatch DOID:12384 +property_value: exactMatch http://identifiers.org/mesh/D004403 +property_value: exactMatch http://identifiers.org/snomedct/111939009 +property_value: exactMatch http://identifiers.org/snomedct/19213003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013369 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3703 xsd:string + +[Term] +id: MONDO:0001524 +name: globe disease +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: obsoletion_candidate +xref: DOID:1242 {source="MONDO:equivalentTo"} +xref: ICD9:360.29 {source="DOID:1242"} +is_a: MONDO:0005328 {source="DOID:1242"} ! eye disorder +property_value: exactMatch DOID:1242 +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0001526 +name: labia minora cancer +def: "A malignant neoplasm that affects the labia minora." [NCIT:C7637] +synonym: "cancer of labium minora" EXACT [MONDO:patterns/cancer] +synonym: "labium minora cancer" EXACT [MONDO:patterns/location] +synonym: "malignant labia minora neoplasm" EXACT [NCIT:C7637] +synonym: "malignant labia minora tumor" EXACT [NCIT:C7637] +synonym: "malignant labium minora neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of labia minora" EXACT [DOID:1243, ICD9CM:184.2, NCIT:C7637] +synonym: "malignant neoplasm of labium minora" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of labium minus" EXACT [DOID:1243, MTH:U001388] +synonym: "malignant neoplasm of the labia minora" EXACT [NCIT:C7637] +synonym: "malignant tumor of labia minora" EXACT [DOID:1243, NCIT:C7637] +synonym: "malignant tumor of the labia minora" EXACT [NCIT:C7637] +xref: DOID:1243 {source="MONDO:equivalentTo"} +xref: ICD10CM:C51.1 {source="DOID:1243", source="MONDO:equivalentTo"} +xref: ICD9:184.2 {source="DOID:1243", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7637 {source="DOID:1243", source="MONDO:equivalentTo"} +xref: SCTID:363447008 {source="DOID:1243", source="MONDO:equivalentTo"} +xref: UMLS:C0496815 {source="DOID:1243", source="MONDO:equivalentTo", source="NCIT:C7637"} +is_a: MONDO:0001528 {source="DOID:1243", source="MONDO:Redundant", source="NCIT:C7637"} ! vulva cancer +is_a: MONDO:0002898 ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004014 ! labium minora +relationship: disease_has_location UBERON:0004014 ! labium minora +property_value: exactMatch DOID:1243 +property_value: exactMatch http://identifiers.org/snomedct/363447008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496815 +property_value: exactMatch https://icd.codes/icd10cm/C51.1 +property_value: exactMatch NCIT:C7637 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001528 +name: vulva cancer +def: "A primary or metastatic malignant neoplasm involving the vulva." [NCIT:C7502] +synonym: "Ca vulva" EXACT [DOID:1245] +synonym: "cancer of mammalian vulva" EXACT [MONDO:patterns/cancer] +synonym: "malignant mammalian vulva neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of mammalian vulva" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the vulva" EXACT [NCIT:C7502] +synonym: "malignant neoplasm of vulva" EXACT [NCIT:C7502] +synonym: "malignant neoplasm of vulva unspecified" EXACT [DOID:1245] +synonym: "malignant neoplasm of vulva, unspecified" EXACT [DOID:1245, ICD9CM:184.4] +synonym: "malignant tumor of the vulva" EXACT [NCIT:C7502] +synonym: "malignant tumor of vulva" EXACT [NCIT:C7502] +synonym: "malignant vulva neoplasm" EXACT [NCIT:C7502] +synonym: "malignant vulva tumor" EXACT [NCIT:C7502] +synonym: "malignant vulvar neoplasm" EXACT [NCIT:C7502] +synonym: "malignant vulvar tumor" EXACT [DOID:1245, NCIT:C7502] +synonym: "mammalian vulva cancer" EXACT [MONDO:patterns/location] +synonym: "neoplasm of vulva" BROAD [DOID:1245] +synonym: "vulval cancer" EXACT [DOID:1245] +synonym: "vulval neoplasm" BROAD [DOID:1245] +synonym: "vulvar cancer" EXACT [MONDO:patterns/location] +xref: DOID:1245 {source="MONDO:equivalentTo"} +xref: GARD:0009349 {source="MONDO:equivalentTo"} +xref: ICD9:184.4 {source="DOID:1245", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014846 {source="DOID:1245", source="MONDO:equivalentTo"} +xref: NCIT:C7502 {source="DOID:1245", source="MONDO:equivalentTo"} +xref: SCTID:363367000 {source="DOID:1245", source="MONDO:equivalentTo"} +is_a: MONDO:0001416 {source="DOID:1245", source="MONDO:Redundant", source="NCIT:C7502"} ! female reproductive organ cancer +is_a: MONDO:0021049 {source="MONDO:Redundant", source="NCIT:C7502"} ! vulvar neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:1245 +property_value: exactMatch http://identifiers.org/mesh/D014846 +property_value: exactMatch http://identifiers.org/snomedct/363367000 +property_value: exactMatch NCIT:C7502 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001531 +name: blood coagulation disease +def: "A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood." [NCIT:C2902] +synonym: "blood coagulation disorder" EXACT [MESH:D001778] +synonym: "coagulation defect" EXACT [NCIT:C2902] +synonym: "coagulation disorder" EXACT [NCIT:C2902] +synonym: "coagulation disorder, blood" EXACT [MESH:D001778] +synonym: "coagulation disorders, blood" EXACT [MESH:D001778] +synonym: "coagulopathy" EXACT [NCIT:C2902, Wikipedia:Coagulopathy] +synonym: "disorder, blood coagulation" EXACT [MESH:D001778] +synonym: "disorders, blood coagulation" EXACT [MESH:D001778] +synonym: "postpartum coagulation defect" EXACT [DOID:1247] +synonym: "postpartum coagulation defect with delivery" EXACT [DOID:1247] +xref: DOID:1247 {source="MONDO:equivalentTo"} +xref: ICD9:286 {source="DOID:1247"} +xref: ICD9:286.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:287.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001778 {source="DOID:1247", source="MONDO:equivalentTo"} +xref: NCIT:C2902 {source="DOID:1247", source="MONDO:equivalentTo"} +xref: SCTID:64779008 {source="DOID:1247", source="MONDO:equivalentTo"} +is_a: MONDO:0005570 {source="DOID:1247", source="MESH:D001778", source="NCIT:C2902/inferred"} ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0007596 ! blood coagulation +relationship: disease_disrupts GO:0007596 ! blood coagulation +property_value: exactMatch DOID:1247 +property_value: exactMatch http://identifiers.org/mesh/D001778 +property_value: exactMatch http://identifiers.org/snomedct/64779008 +property_value: exactMatch NCIT:C2902 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0001535 +name: vagus nerve disorder +def: "A disease involving the vagus nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of vagus nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vagus nerve" EXACT [] +synonym: "disorder of pneumogastric [10th] nerve" EXACT [DOID:12491, ICD9CM:352.3] +synonym: "disorder of vagal nerve" EXACT [DOID:12491] +synonym: "disorder of vagus nerve" EXACT [MONDO:patterns/location_top] +synonym: "vagus nerve disease" EXACT [MONDO:patterns/location] +synonym: "vagus nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "Vagus nerve disorder" EXACT [DOID:12491, NCIT:C27591] +xref: DOID:12491 {source="MONDO:equivalentTo"} +xref: ICD9:352.3 {source="MONDO:equivalentTo", source="DOID:12491", source="MONDO:i2s"} +xref: MESH:D020421 {source="MONDO:equivalentTo", source="DOID:12491"} +xref: NCIT:C27591 {source="MONDO:equivalentTo", source="DOID:12491"} +xref: SCTID:73765005 {source="MONDO:equivalentTo", source="DOID:12491"} +xref: UMLS:C0152179 {source="MONDO:equivalentTo", source="DOID:12491", source="NCIT:C27591"} +is_a: MONDO:0002639 {source="DOID:12491"} ! glossopharyngeal nerve disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001759 ! vagus nerve +relationship: disease_has_location UBERON:0001759 ! vagus nerve +property_value: exactMatch DOID:12491 +property_value: exactMatch http://identifiers.org/mesh/D020421 +property_value: exactMatch http://identifiers.org/snomedct/73765005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152179 +property_value: exactMatch NCIT:C27591 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001563 +name: vestibulocochlear nerve disorder +def: "A disease involving the vestibulocochlear nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "acoustic nerve disease" EXACT [DOID:12657, ICD9CM:388.5] +synonym: "acoustic nerve disorder" EXACT [NCIT:C27207] +synonym: "acoustic nerve disorder NOS" EXACT [NCIT:C27207] +synonym: "disease of vestibulocochlear nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vestibulocochlear nerve" EXACT [] +synonym: "disorder of acoustic nerve" EXACT [] +synonym: "disorder of acoustovestibular nerve" RELATED [] +synonym: "disorder of eighth nerve" RELATED [] +synonym: "disorder of the vestibulocochlear nerve" RELATED [] +synonym: "disorder of vestibulocochlear nerve" EXACT [MONDO:patterns/location_top] +synonym: "vestibulocochlear nerve disease" EXACT [MONDO:patterns/location] +synonym: "vestibulocochlear nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vestibulocochlear nerve disorder" EXACT [NCIT:C27207] +xref: DOID:12657 {source="MONDO:equivalentTo"} +xref: ICD9:388.5 {source="DOID:12657"} +xref: MESH:D000160 {source="DOID:12657", source="MONDO:equivalentTo"} +xref: NCIT:C27207 {source="DOID:12657", source="MONDO:equivalentTo"} +xref: SCTID:77949003 {source="DOID:12657", source="MONDO:equivalentTo"} +xref: UMLS:C0001163 {source="DOID:12657", source="MONDO:equivalentTo"} +is_a: MONDO:0002453 {source="DOID:12657", source="MESH:D000160"} ! retrocochlear disease +is_a: MONDO:0003569 {source="DOID:12657", source="MESH:D000160", source="MONDO:Redundant", source="NCIT:C27207"} ! cranial nerve neuropathy +is_a: MONDO:0003620 {source="DOID:12657/inferred", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001648 ! vestibulocochlear nerve +relationship: disease_has_location UBERON:0001648 ! vestibulocochlear nerve +property_value: exactMatch DOID:12657 +property_value: exactMatch http://identifiers.org/mesh/D000160 +property_value: exactMatch http://identifiers.org/snomedct/77949003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001163 +property_value: exactMatch NCIT:C27207 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001574 +name: capillary disorder +def: "A disease involving a capillary." [https://orcid.org/0000-0002-6601-2165] +synonym: "capillary disease" EXACT [MONDO:patterns/location] +synonym: "capillary disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of capillaries" EXACT [DOID:1271] +synonym: "disease of capillary" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of capillary" EXACT [] +synonym: "disorder of capillary" EXACT [MONDO:patterns/location_top] +xref: DOID:1271 {source="MONDO:equivalentTo"} +xref: ICD9:448 {source="DOID:1271"} +xref: ICD9:448.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:58729003 {source="MONDO:equivalentTo", source="DOID:1271"} +xref: UMLS:C0155765 {source="MONDO:equivalentTo", source="DOID:1271"} +is_a: MONDO:0005385 {source="DOID:1271", source="MONDO:Redundant"} ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001982 ! capillary +relationship: disease_has_location UBERON:0001982 ! capillary +property_value: exactMatch DOID:1271 +property_value: exactMatch http://identifiers.org/snomedct/58729003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155765 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001580 +name: lacrimal duct cancer +def: "A primary or metastatic malignant neoplasm affecting the lacrimal duct." [NCIT:C3567] +synonym: "cancer of lacrimal drainage system" EXACT [MONDO:patterns/cancer] +synonym: "lacrimal drainage system cancer" EXACT [MONDO:patterns/location] +synonym: "malignant lacrimal drainage system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant lacrimal duct neoplasm" EXACT [NCIT:C3567] +synonym: "malignant lacrimal duct tumor" EXACT [NCIT:C3567] +synonym: "malignant neoplasm of lacrimal drainage system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of lacrimal duct" EXACT [DOID:12756, ICD9CM:190.7, NCIT:C3567] +synonym: "malignant neoplasm of the lacrimal duct" EXACT [NCIT:C3567] +synonym: "malignant tumor of lacrimal duct" EXACT [DOID:12756, NCIT:C3567] +synonym: "malignant tumor of the lacrimal duct" EXACT [NCIT:C3567] +xref: DOID:12756 {source="MONDO:equivalentTo"} +xref: ICD9:190.7 {source="DOID:12756", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3567 {source="DOID:12756", source="MONDO:equivalentTo"} +xref: SCTID:188274004 {source="DOID:12756", source="MONDO:equivalentTo"} +xref: UMLS:C0153631 {source="DOID:12756", source="MONDO:equivalentTo", source="NCIT:C3567"} +is_a: MONDO:0002460 {source="DOID:12756", source="MONDO:Redundant", source="NCIT:C3567"} ! lacrimal system cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001850 ! lacrimal drainage system +relationship: disease_has_location UBERON:0001850 ! lacrimal drainage system +property_value: exactMatch DOID:12756 +property_value: exactMatch http://identifiers.org/snomedct/188274004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153631 +property_value: exactMatch NCIT:C3567 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001593 +name: rectal disorder +def: "A disease that involves the rectum." [MONDO:patterns/location] +synonym: "disease of rectum" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of rectum" EXACT [] +synonym: "disorder of rectum" EXACT [MONDO:patterns/location_top] +synonym: "rectal disorder" EXACT [] +synonym: "rectum disease" EXACT [MONDO:patterns/location] +synonym: "rectum disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1285 {source="MONDO:equivalentTo"} +xref: ICD9:569.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012002 {source="DOID:1285", source="MONDO:equivalentTo"} +xref: SCTID:5964004 {source="DOID:1285", source="MONDO:equivalentTo"} +xref: UMLS:C0034882 {source="DOID:1285", source="MONDO:equivalentTo"} +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001052 ! rectum +relationship: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch DOID:1285 +property_value: exactMatch http://identifiers.org/mesh/D012002 +property_value: exactMatch http://identifiers.org/snomedct/5964004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034882 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001597 +name: submandibular gland disorder +def: "A disease involving the submandibular gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of submandibular gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of submandibular gland" EXACT [] +synonym: "disorder of submandibular gland" EXACT [MONDO:patterns/location_top] +synonym: "submandibular gland disease" EXACT [MONDO:patterns/location] +synonym: "submandibular gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:12897 {source="MONDO:equivalentTo"} +xref: MESH:D013364 {source="DOID:12897", source="MONDO:equivalentTo"} +xref: UMLS:C0038557 {source="DOID:12897", source="MONDO:equivalentTo"} +is_a: MONDO:0001142 {source="DOID:12897", source="MESH:D013364", source="MONDO:Entailed", source="MONDO:Redundant"} ! salivary gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001736 ! submandibular gland +relationship: disease_has_location UBERON:0001736 ! submandibular gland +property_value: exactMatch DOID:12897 +property_value: exactMatch http://identifiers.org/mesh/D013364 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038557 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001602 +name: labia minora carcinoma +def: "A carcinoma that arises from the labia minora." [NCIT:C9364] +synonym: "carcinoma of labia minora" EXACT [DOID:1293, NCIT:C9364] +synonym: "carcinoma of labium minora" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the labia minora" EXACT [NCIT:C9364] +synonym: "labia minora cancer" BROAD [DOID:1293, NCIT:C9364] +synonym: "labia minora carcinoma" EXACT [NCIT:C9364] +synonym: "labium minora carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:1293 {source="MONDO:equivalentTo"} +xref: NCIT:C9364 {source="MONDO:equivalentTo", source="DOID:1293"} +xref: UMLS:C1334357 {source="NCIT:C9364", source="MONDO:equivalentTo", source="DOID:1293"} +is_a: MONDO:0001526 {source="DOID:1293", source="MONDO:Redundant", source="NCIT:C9364"} ! labia minora cancer +is_a: MONDO:0002656 ! skin carcinoma +is_a: MONDO:0005215 {source="DOID:1293", source="MONDO:Redundant", source="NCIT:C9364"} ! vulvar carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0004014 ! labium minora +property_value: exactMatch DOID:1293 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334357 +property_value: exactMatch NCIT:C9364 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0001608 +name: vagus nerve neoplasm +def: "A neoplasm involving a vagus nerve." [MONDO:patterns/neoplasm] +synonym: "neoplasm of tenth cranial nerve" EXACT [NCIT:C5831] +synonym: "neoplasm of the tenth cranial nerve" EXACT [NCIT:C5831] +synonym: "neoplasm of the Vagus nerve" EXACT [NCIT:C5831] +synonym: "neoplasm of Vagus nerve" EXACT [NCIT:C5831] +synonym: "neoplasm of vagus nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "tenth cranial nerve neoplasm" EXACT [NCIT:C5831] +synonym: "tenth cranial nerve neoplasms" EXACT [NCIT:C5831] +synonym: "tenth cranial nerve tumor" EXACT [NCIT:C5831] +synonym: "tenth cranial nerve tumors" EXACT [NCIT:C5831] +synonym: "tumor of tenth cranial nerve" EXACT [NCIT:C5831] +synonym: "tumor of the tenth cranial nerve" EXACT [NCIT:C5831] +synonym: "tumor of the Vagus nerve" EXACT [NCIT:C5831] +synonym: "tumor of Vagus nerve" EXACT [NCIT:C5831] +synonym: "tumor of vagus nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "Vagus nerve neoplasm" EXACT [NCIT:C5831] +synonym: "vagus nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "Vagus nerve neoplasms" EXACT [NCIT:C5831] +synonym: "Vagus nerve tumor" EXACT [NCIT:C5831] +synonym: "vagus nerve tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "Vagus nerve tumors" EXACT [DOID:12984, NCIT:C5831] +synonym: "Xth cranial nerve neoplasms" EXACT [NCIT:C5831] +synonym: "Xth cranial nerve tumors" EXACT [NCIT:C5831] +xref: DOID:12984 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5831 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:12984"} +xref: SCTID:126976007 {source="MONDO:equivalentTo", source="DOID:12984"} +xref: UMLS:C1263901 {source="MONDO:equivalentTo", source="NCIT:C5831", source="DOID:12984"} +is_a: MONDO:0001535 {source="MONDO:Redundant", source="NCIT:C5831"} ! vagus nerve disorder +is_a: MONDO:0002638 ! glossopharyngeal nerve neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001759 ! vagus nerve +property_value: exactMatch DOID:12984 +property_value: exactMatch http://identifiers.org/snomedct/126976007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263901 +property_value: exactMatch NCIT:C5831 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001610 +name: acute dacryocystitis +def: "Acute form of dacryocystitis." [MONDO:patterns/acute] +synonym: "dacryocystitis - acute" EXACT [DOID:12996] +synonym: "dacryocystitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:12996 {source="MONDO:equivalentTo"} +xref: ICD9:375.32 {source="DOID:12996", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:25470000 {source="DOID:12996", source="MONDO:equivalentTo"} +xref: UMLS:C0155237 {source="DOID:12996", source="MONDO:equivalentTo"} +is_a: MONDO:0004926 {source="DOID:12996", source="MONDO:Redundant"} ! dacryocystitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004926 ! dacryocystitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:12996 +property_value: exactMatch http://identifiers.org/snomedct/25470000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155237 + +[Term] +id: MONDO:0001618 +name: balanoposthitis +xref: DOID:13031 {source="MONDO:equivalentTo"} +xref: ICD10CM:N47.6 {source="DOID:13031", source="MONDO:equivalentTo"} +xref: ICD9:607.1 {source="DOID:13031"} +xref: SCTID:46090001 {source="DOID:13031", source="MONDO:equivalentTo"} +xref: UMLS:C0004691 {source="DOID:13031", source="MONDO:equivalentTo"} +is_a: MONDO:0006672 ! balanitis +is_a: MONDO:0021164 ! posthitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001299 ! glans penis +intersection_of: disease_has_inflammation_site UBERON:0001332 ! prepuce of penis +property_value: exactMatch DOID:13031 +property_value: exactMatch http://identifiers.org/snomedct/46090001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004691 +property_value: exactMatch https://icd.codes/icd10cm/N47.6 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0001624 +name: acute sphenoidal sinusitis +def: "Acute form of sphenoid sinusitis." [MONDO:patterns/acute] +synonym: "acute sphenoid sinusitis" EXACT [MONDO:design_pattern] +synonym: "sphenoid sinusitis, acute" EXACT [MONDO:patterns/acute] +synonym: "sphenoidal sinus -acute" EXACT [DOID:13046] +xref: DOID:13046 {source="MONDO:equivalentTo"} +xref: ICD10CM:J01.3 {source="MONDO:equivalentTo", source="DOID:13046"} +xref: ICD9:461.3 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13046"} +xref: SCTID:77919000 {source="MONDO:equivalentTo", source="DOID:13046"} +xref: UMLS:C0155807 {source="MONDO:equivalentTo", source="DOID:13046"} +is_a: MONDO:0005964 {source="DOID:13046", source="MONDO:Redundant"} ! sphenoid sinusitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0005964 ! sphenoid sinusitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:13046 +property_value: exactMatch http://identifiers.org/snomedct/77919000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155807 +property_value: exactMatch https://icd.codes/icd10cm/J01.3 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0001627 +name: dementia +def: "Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders." [NCIT:P378] +synonym: "dementia" EXACT [NCIT:C4786] +synonym: "dementia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1307 {source="MONDO:equivalentTo"} +xref: GARD:0011946 {source="MONDO:equivalentTo"} +xref: ICD9:290.8 {source="DOID:1307"} +xref: ICD9:294.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:294.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003704 {source="MONDO:equivalentTo"} +xref: NCIT:C4786 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:52448006 {source="MONDO:equivalentTo"} +is_a: MONDO:0002039 {source="DOID:1307", source="MESH:D003704", source="MONDO:Redundant", source="NCIT:C4786"} ! cognitive disorder +intersection_of: MONDO:0002039 ! cognitive disorder +intersection_of: disease_has_major_feature HP:0000726 ! Dementia +relationship: disease_has_major_feature HP:0000726 ! Dementia +property_value: exactMatch DOID:1307 +property_value: exactMatch http://identifiers.org/mesh/D003704 +property_value: exactMatch http://identifiers.org/snomedct/52448006 +property_value: exactMatch NCIT:C4786 +property_value: IAO:0000589 "dementia (disease)" xsd:string + +[Term] +id: MONDO:0001650 +name: acute cystitis +def: "An acute infection of the bladder. It is usually caused by bacteria. Signs and symptoms include increased frequency of urination, pain or burning during urination, fever, cloudy or bloody urine, and suprapubic pain." [NCIT:P378] +synonym: "acute cystitis" EXACT [MONDO:ambiguous] +synonym: "acute cystitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "cystitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:13148 {source="MONDO:equivalentTo"} +xref: ICD10CM:N30.0 {source="MONDO:equivalentTo", source="DOID:13148"} +xref: ICD9:595.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13148"} +xref: NCIT:C26934 {source="MONDO:equivalentTo", source="DOID:13148"} +xref: SCTID:68226007 {source="MONDO:equivalentTo", source="DOID:13148"} +xref: UMLS:C0149523 {source="MONDO:equivalentTo", source="NCIT:C26934", source="DOID:13148"} +is_a: MONDO:0005247 {source="https://github.com/monarch-initiative/mondo/issues/841"} ! bacterial urinary tract infection +is_a: MONDO:0006032 ! cystitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0006032 ! cystitis +intersection_of: has_modifier PATO:0000389 ! acute +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +property_value: exactMatch DOID:13148 +property_value: exactMatch http://identifiers.org/snomedct/68226007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149523 +property_value: exactMatch https://icd.codes/icd10cm/N30.0 +property_value: exactMatch NCIT:C26934 +property_value: excluded_subClassOf MONDO:0006032 {source="DOID:13148", source="MONDO:Redundant", source="NCIT:C26934/inferred"} +property_value: IAO:0000589 "acute cystitis (disease)" xsd:string + +[Term] +id: MONDO:0001651 +name: scrotum squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the scrotum. It has been associated with exposure to environmental and industrial carcinogens. The prognosis depends on the extent of lymph node involvement." [NCIT:P378] +synonym: "scrotal squamous cell carcinoma" EXACT [DOID:13159, NCIT:C4643] +synonym: "scrotum squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of scrotum" RELATED [DOID:13159] +synonym: "squamous cell carcinoma of the scrotum" EXACT [NCIT:C4643] +xref: DOID:13159 {source="MONDO:equivalentTo"} +xref: NCIT:C4643 {source="MONDO:equivalentTo", source="DOID:13159"} +xref: SCTID:276860003 {source="MONDO:equivalentTo", source="DOID:13159"} +xref: UMLS:C0349551 {source="MONDO:equivalentTo", source="NCIT:C4643", source="DOID:13159"} +is_a: MONDO:0002650 {source="DOID:13159", source="MONDO:Redundant", source="NCIT:C4643"} ! scrotal carcinoma +is_a: MONDO:0005096 {source="DOID:13159", source="MONDO:Redundant", source="NCIT:C4643"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch DOID:13159 +property_value: exactMatch http://identifiers.org/snomedct/276860003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349551 +property_value: exactMatch NCIT:C4643 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0001653 +name: prepuce cancer +def: "A malignant neoplasm involving the prepuce." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of prepuce" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of foreskin" EXACT [DOID:13168] +synonym: "malignant neoplasm of prepuce" EXACT [MONDO:patterns/cancer] +synonym: "malignant prepuce neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of foreskin" EXACT [DOID:13168] +synonym: "prepuce cancer" EXACT [MONDO:patterns/location] +xref: DOID:13168 {source="MONDO:equivalentTo"} +xref: ICD9:187.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13168"} +xref: SCTID:363450006 {source="MONDO:equivalentTo", source="DOID:13168"} +xref: UMLS:C0153598 {source="MONDO:equivalentTo", source="DOID:13168"} +is_a: MONDO:0002149 ! reproductive system cancer +is_a: MONDO:0002898 {source="DOID:13168"} ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0011374 ! prepuce +relationship: disease_has_location UBERON:0011374 ! prepuce +property_value: exactMatch DOID:13168 +property_value: exactMatch http://identifiers.org/snomedct/363450006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153598 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001654 +name: spermatic cord cancer +def: "A malignant neoplasm involving the spermatic cord." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of spermatic cord" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of spermatic cord" EXACT [MONDO:patterns/cancer, NCIT:C3559] +synonym: "malignant neoplasm of the spermatic cord" EXACT [NCIT:C3559] +synonym: "malignant spermatic cord neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant spermatic cord tumor" EXACT [NCIT:C3559] +synonym: "malignant tumor of spermatic cord" EXACT [NCIT:C3559] +synonym: "malignant tumor of the spermatic cord" EXACT [DOID:13169, NCIT:C3559] +synonym: "spermatic cord Ca" EXACT [DOID:13169] +synonym: "spermatic cord cancer" EXACT [MONDO:patterns/location] +xref: DOID:13169 {source="MONDO:equivalentTo"} +xref: ICD9:187.6 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13169"} +xref: NCIT:C3559 {source="MONDO:equivalentTo", source="DOID:13169"} +xref: SCTID:363453008 {source="MONDO:equivalentTo", source="DOID:13169"} +xref: UMLS:C0153603 {source="MONDO:equivalentTo", source="DOID:13169", source="NCIT:C3559"} +is_a: MONDO:0005836 {source="DOID:13169", source="MONDO:Redundant", source="NCIT:C3559"} ! male reproductive organ cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0005352 ! spermatic cord +relationship: disease_has_location UBERON:0005352 ! spermatic cord +property_value: exactMatch DOID:13169 +property_value: exactMatch http://identifiers.org/snomedct/363453008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153603 +property_value: exactMatch NCIT:C3559 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001657 +name: brain cancer +def: "A primary or metastatic malignant neoplasm affecting the brain." [NCIT:C3568] +synonym: "adult brain tumor" NARROW [DOID:1319] +synonym: "adult malignant brain neoplasm" NARROW [DOID:1319] +synonym: "brain cancer" EXACT [MONDO:patterns/location, NCIT:C3568] +synonym: "brain neoplasm" BROAD [DOID:1319] +synonym: "brain neoplasm, adult" RELATED [DOID:1319, NCIT:C7710] +synonym: "brain neoplasms, malignant" EXACT [NCIT:C3568] +synonym: "brain tumor, adult" RELATED [GARD:0009307] +synonym: "BT - brain tumour" RELATED [DOID:1319] +synonym: "cancer of brain" EXACT [MONDO:patterns/cancer, NCIT:C3568] +synonym: "cancer of the brain" EXACT [NCIT:C3568] +synonym: "malignant brain neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3568] +synonym: "malignant brain tumor" EXACT [NCIT:C3568] +synonym: "malignant brain tumour" EXACT [DOID:1319] +synonym: "malignant neoplasm of brain" EXACT [MONDO:patterns/cancer, NCIT:C3568] +synonym: "malignant neoplasm of the brain" EXACT [NCIT:C3568] +synonym: "malignant primary brain neoplasm" NARROW [DOID:1319, NCIT:C4954] +synonym: "malignant primary brain tumor" NARROW [DOID:1319] +synonym: "malignant tumor of adult brain" NARROW [DOID:1319, NCIT:C5115] +synonym: "malignant tumor of brain" EXACT [DOID:1319, NCIT:C3568] +synonym: "malignant tumor of the brain" EXACT [NCIT:C3568] +synonym: "neoplasm of unspecified nature of brain" RELATED [DOID:1319, ICD9CM:239.6] +synonym: "primary brain neoplasm" RELATED [DOID:1319, NCIT:C4952] +synonym: "primary brain tumor" RELATED [DOID:1319] +synonym: "primary malignant neoplasm of brain" EXACT [DOID:1319] +synonym: "tumor of the brain" BROAD [DOID:1319, NCIT:C2907] +xref: CSP:2006-2736 {source="DOID:1319"} +xref: DOID:1319 {source="MONDO:equivalentTo"} +xref: GARD:0009307 {source="MONDO:equivalentTo"} +xref: ICD9:191 {source="DOID:1319"} +xref: ICD9:191.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:191.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1319"} +xref: ICD9:239.6 {source="DOID:1319"} +xref: MESH:D001932 {source="MONDO:equivalentTo", source="DOID:1319"} +xref: NCIT:C3568 {source="MONDO:equivalentTo", source="DOID:1319"} +xref: NCIT:C4952 {source="DOID:1319", source="MONDO:directSiblingOf"} +xref: SCTID:428061005 {source="MONDO:equivalentTo", source="DOID:1319"} +is_a: MONDO:0002714 {source="DOID:1319", source="MESH:D001932", source="MONDO:Redundant", source="NCIT:C3568/inferred"} ! central nervous system cancer +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C3568"} ! brain neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:1319 +property_value: exactMatch http://identifiers.org/mesh/D001932 +property_value: exactMatch http://identifiers.org/snomedct/428061005 +property_value: exactMatch NCIT:C3568 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001672 +name: bronchus cancer +def: "A malignant neoplasm involving the bronchus" [https://orcid.org/0000-0002-6601-2165] +synonym: "bronchus cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of bronchus" EXACT [MONDO:patterns/cancer] +synonym: "malignant bronchus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of bronchus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of bronchus and lung" NARROW [DOID:1325] +synonym: "malignant neoplasm of bronchus and lung, unspecified" NARROW [DOID:1325, ICD9CM:162.9] +synonym: "malignant neoplasm of bronchus or lung" RELATED [DOID:1325] +xref: DOID:1325 {source="MONDO:equivalentTo"} +xref: ICD9:162.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:162.9 {source="MONDO:relatedTo", source="MONDO:i2s", source="DOID:1325"} +xref: SCTID:363493006 {source="MONDO:equivalentTo"} +is_a: MONDO:0000376 {source="DOID:1325", source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0002807 {source="MONDO:Redundant"} ! bronchial neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002185 ! bronchus +property_value: exactMatch DOID:1325 +property_value: exactMatch http://identifiers.org/snomedct/363493006 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001673 +name: diarrheal disease +def: "The condition of having at least three loose or liquid bowel movements each day." [Wikipedia:Diarrhea] +synonym: "diarrhea" EXACT [DOID:13250] +synonym: "diarrhea of presumed infectious origin" RELATED [DOID:13250] +synonym: "diarrheal disease" EXACT [] +synonym: "diarrheal disorder" EXACT [] +synonym: "diarrhoea" EXACT [DOID:13250] +synonym: "frequent stools" EXACT [NCIT:C2987] +synonym: "loose stools" EXACT [NCIT:C2987] +xref: DOID:13250 {source="MONDO:equivalentTo"} +xref: HP:0002014 {source="MONDO:otherHierarchy"} +xref: ICD9:009.2 {source="DOID:13250"} +xref: MESH:D003967 {source="MONDO:equivalentTo", source="MONDO:otherHierarchy", source="DOID:13250"} +xref: NCIT:C2987 {source="MONDO:equivalentTo", source="MONDO:otherHierarchy", source="MONDO:exact-label-match"} +xref: SCTID:128333008 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 {source="DOID:13250", source="MONDO:Redundant"} ! digestive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_major_feature HP:0002014 ! Diarrhea +relationship: disease_causes_feature HP:0001944 ! Dehydration +relationship: disease_has_major_feature HP:0002014 ! Diarrhea +property_value: exactMatch DOID:13250 +property_value: exactMatch http://identifiers.org/mesh/D003967 +property_value: exactMatch http://identifiers.org/snomedct/128333008 +property_value: exactMatch NCIT:C2987 + +[Term] +id: MONDO:0001674 +name: diverticulitis of colon +def: "Inflammation of the colonic diverticula, generally with abscess formation and subsequent perforation." [MESH:D004239] +synonym: "colon diverticulitis" EXACT [MONDO:patterns/location] +synonym: "colonic diverticular disease" EXACT [DOID:13254] +xref: DOID:13254 {source="MONDO:equivalentTo"} +xref: ICD9:562.11 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:562.12 {source="DOID:13254"} +xref: MESH:D004239 {source="MONDO:equivalentTo", source="DOID:13254"} +xref: SCTID:111359004 {source="MONDO:equivalentTo"} +xref: UMLS:C0012814 {source="MONDO:equivalentTo"} +is_a: MONDO:0003409 {source="DOID:13254", source="MESH:D004239/inferred", source="MONDO:Redundant"} ! colonic disorder +is_a: MONDO:0004235 {source="DOID:13254", source="MONDO:Redundant"} ! diverticulitis +intersection_of: MONDO:0004235 ! diverticulitis +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:13254 +property_value: exactMatch http://identifiers.org/mesh/D004239 +property_value: exactMatch http://identifiers.org/snomedct/111359004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0012814 + +[Term] +id: MONDO:0001680 +name: vaginal mullerian papilloma +def: "A benign papilloma that arises from the vagina in infants and young women." [NCIT:C40255] +synonym: "vaginal Muellerian papilloma" EXACT [DOID:133] +synonym: "vaginal Mullerian papilloma" EXACT [NCIT:C40255] +synonym: "vaginal Müllerian papilloma" EXACT [NCIT:C40255] +xref: DOID:133 {source="MONDO:equivalentTo"} +xref: NCIT:C40255 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:133"} +xref: UMLS:C1519926 {source="MONDO:equivalentTo", source="DOID:133", source="NCIT:C40255"} +is_a: MONDO:0000647 {source="MONDO:Redundant", source="NCIT:C40255"} ! benign vaginal neoplasm +is_a: MONDO:0001704 {source="DOID:133", source="MONDO:Redundant", source="NCIT:C40255"} ! vaginal glandular neoplasm +is_a: MONDO:0021078 ! glandular papilloma +intersection_of: MONDO:0000647 {source="NCIT:C40255"} ! benign vaginal neoplasm +intersection_of: MONDO:0001704 {source="NCIT:C40255"} ! vaginal glandular neoplasm +intersection_of: MONDO:0002363 {source="NCIT:C40255"} ! papilloma +property_value: exactMatch DOID:133 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519926 +property_value: exactMatch NCIT:C40255 + +[Term] +id: MONDO:0001691 +name: laryngeal cartilage cancer +def: "A malignant neoplasm involving the laryngeal cartilage." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of laryngeal cartilage" EXACT [MONDO:patterns/cancer] +synonym: "laryngeal cartilage cancer" EXACT [MONDO:patterns/location] +synonym: "malignant laryngeal cartilage neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of laryngeal cartilage" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of laryngeal cartilages" EXACT [DOID:13348, ICD9CM:161.3] +synonym: "malignant tumor of laryngeal cartilage" EXACT [DOID:13348] +xref: DOID:13348 {source="MONDO:equivalentTo"} +xref: ICD9:161.3 {source="DOID:13348", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363431006 {source="DOID:13348", source="MONDO:equivalentTo"} +xref: UMLS:C0153486 {source="DOID:13348", source="MONDO:equivalentTo"} +is_a: MONDO:0002129 ! bone cancer +is_a: MONDO:0002352 {source="DOID:13348", source="MONDO:Redundant"} ! larynx cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001739 ! laryngeal cartilage +relationship: disease_has_location UBERON:0001739 ! laryngeal cartilage +property_value: exactMatch DOID:13348 +property_value: exactMatch http://identifiers.org/snomedct/363431006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153486 +property_value: excluded_subClassOf MONDO:0002129 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001702 +name: labia majora carcinoma +def: "A carcinoma that arises from the labia majora." [NCIT:C9363] +synonym: "carcinoma of labia majora" EXACT [DOID:13389, NCIT:C9363] +synonym: "carcinoma of labium majora" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the labia majora" EXACT [NCIT:C9363] +synonym: "labia majora cancer" EXACT [DOID:13389, NCIT:C9363] +synonym: "labia majora carcinoma" EXACT [NCIT:C9363] +synonym: "labium majora carcinoma" EXACT [] +xref: DOID:13389 {source="MONDO:equivalentTo"} +xref: NCIT:C9363 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:13389"} +xref: UMLS:C1334356 {source="MONDO:equivalentTo", source="DOID:13389", source="NCIT:C9363"} +is_a: MONDO:0001403 {source="DOID:13389", source="MONDO:Redundant", source="NCIT:C9363"} ! labium majus cancer +is_a: MONDO:0002656 {source="DOID:13389", source="MONDO:Entailed", source="MONDO:Redundant"} ! skin carcinoma +is_a: MONDO:0005215 {source="DOID:13389", source="MONDO:Redundant", source="NCIT:C9363"} ! vulvar carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0004085 ! labium majora +property_value: exactMatch DOID:13389 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334356 +property_value: exactMatch NCIT:C9363 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0001704 +name: vaginal glandular neoplasm +def: "A benign or malignant neoplasm that arises from the vagina and is characterized by the presence of neoplastic glandular epithelial cells. Representative examples include adenoma, endometrioid adenocarcinoma, and clear cell adenocarcinoma." [NCIT:C40250] +synonym: "vagina glandular cell neoplasm" EXACT [MONDO:patterns/location] +synonym: "vaginal glandular neoplasm" EXACT [NCIT:C40250] +synonym: "vaginal glandular tumor" EXACT [NCIT:C40250] +xref: DOID:134 {source="MONDO:equivalentTo"} +xref: NCIT:C40250 {source="MONDO:equivalentTo", source="DOID:134"} +xref: UMLS:C1519921 {source="MONDO:equivalentTo", source="NCIT:C40250", source="DOID:134"} +is_a: MONDO:0021050 {source="MONDO:Redundant", source="NCIT:C40250"} ! vaginal neoplasm +is_a: MONDO:0024276 ! glandular cell neoplasm +intersection_of: MONDO:0024276 {source="NCIT:C40250"} ! glandular cell neoplasm +intersection_of: disease_has_location UBERON:0000996 {source="NCIT:C40250"} ! vagina +property_value: exactMatch DOID:134 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519921 +property_value: exactMatch NCIT:C40250 + +[Term] +id: MONDO:0001718 +name: scleritis +def: "Inflammation of the sclera." [NCIT:P378] +synonym: "scleritis" EXACT [MONDO:ambiguous] +synonym: "scleritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:13452 {source="MONDO:equivalentTo"} +xref: GARD:0012911 {source="MONDO:equivalentTo"} +xref: HP:0100532 {source="MONDO:otherHierarchy"} +xref: ICD9:379.00 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13452"} +xref: MESH:D015423 {source="MONDO:equivalentTo", source="DOID:13452"} +xref: NCIT:C119046 {source="MONDO:equivalentTo", source="DOID:13452"} +xref: SCTID:78370002 {source="MONDO:equivalentTo", source="DOID:13452"} +xref: UMLS:C0036416 {source="NCIT:C119046", source="MONDO:equivalentTo", source="DOID:13452"} +is_a: MONDO:0001269 {source="DOID:13452", source="MESH:D015423", source="NCIT:C119046"} ! scleral disorder +property_value: exactMatch DOID:13452 +property_value: exactMatch http://identifiers.org/mesh/D015423 +property_value: exactMatch http://identifiers.org/snomedct/78370002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036416 +property_value: exactMatch NCIT:C119046 +property_value: IAO:0000589 "scleritis (disease)" xsd:string + +[Term] +id: MONDO:0001724 +name: supraglottis cancer +def: "A malignant neoplasm that affects the supraglottic area of the larynx. The vast majority of cases are squamous cell carcinomas." [NCIT:C3545] +synonym: "Ca larynx - supraglottis" EXACT [DOID:13476] +synonym: "cancer of supraglottic part of larynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of extrinsic larynx" EXACT [DOID:13476] +synonym: "malignant neoplasm of supraglottic part of larynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of supraglottis" EXACT [DOID:13476, ICD9CM:161.1, NCIT:C3545] +synonym: "malignant neoplasm of the supraglottis" EXACT [NCIT:C3545] +synonym: "malignant supraglottic neoplasm" EXACT [NCIT:C3545] +synonym: "malignant supraglottic part of larynx neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant supraglottic tumor" EXACT [DOID:13476, NCIT:C3545] +synonym: "malignant supraglottis neoplasm" EXACT [NCIT:C3545] +synonym: "malignant supraglottis tumor" EXACT [NCIT:C3545] +synonym: "malignant tumor of supraglottis" EXACT [NCIT:C3545] +synonym: "malignant tumor of the supraglottis" EXACT [NCIT:C3545] +synonym: "supraglottic part of larynx cancer" EXACT [MONDO:patterns/location] +xref: DOID:13476 {source="MONDO:equivalentTo"} +xref: ICD10CM:C32.1 {source="MONDO:equivalentTo", source="DOID:13476"} +xref: ICD9:161.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13476"} +xref: NCIT:C3545 {source="MONDO:equivalentTo", source="DOID:13476"} +xref: SCTID:187842004 {source="MONDO:equivalentTo", source="DOID:13476"} +xref: UMLS:C0153484 {source="MONDO:equivalentTo", source="NCIT:C3545", source="DOID:13476"} +is_a: MONDO:0002352 {source="DOID:13476", source="MONDO:Redundant", source="NCIT:C3545"} ! larynx cancer +is_a: MONDO:0004427 {source="MONDO:Redundant", source="NCIT:C3545"} ! supraglottis neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0036263 ! supraglottic part of larynx +property_value: exactMatch DOID:13476 +property_value: exactMatch http://identifiers.org/snomedct/187842004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153484 +property_value: exactMatch https://icd.codes/icd10cm/C32.1 +property_value: exactMatch NCIT:C3545 +property_value: excluded_synonym "supraglottis" xsd:string {source="DOID:13476"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001732 +name: trigonitis +def: "Inflammation of the trigone of the urinary bladder." [NCIT:P378] +synonym: "inflammation of trigone of urinary bladder" EXACT [] +synonym: "trigone of urinary bladder inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:13507 {source="MONDO:equivalentTo"} +xref: ICD10CM:N30.3 {source="DOID:13507", source="MONDO:equivalentTo"} +xref: ICD9:595.3 {source="DOID:13507", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C123175 {source="DOID:13507", source="MONDO:equivalentTo"} +xref: SCTID:74445007 {source="DOID:13507", source="MONDO:equivalentTo"} +xref: UMLS:C1261278 {source="DOID:13507", source="NCIT:C123175", source="MONDO:equivalentTo"} +is_a: MONDO:0006032 {source="DOID:13507", source="MONDO:Redundant", source="NCIT:C123175"} ! cystitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001257 ! trigone of urinary bladder +relationship: disease_has_inflammation_site UBERON:0001257 ! trigone of urinary bladder +property_value: exactMatch DOID:13507 +property_value: exactMatch http://identifiers.org/snomedct/74445007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1261278 +property_value: exactMatch https://icd.codes/icd10cm/N30.3 +property_value: exactMatch NCIT:C123175 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001735 +name: paranasal sinus disorder +def: "A disease involving the paranasal sinus." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of paranasal sinus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of paranasal sinus" EXACT [] +synonym: "disorder of nasal sinus" EXACT [DOID:1352] +synonym: "disorder of paranasal sinus" EXACT [MONDO:patterns/location_top] +synonym: "paranasal sinus disease" EXACT [MONDO:patterns/location, NCIT:C26843] +synonym: "paranasal sinus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "paranasal sinus disorder" EXACT [NCIT:C26843] +synonym: "sinus disorder" EXACT [NCIT:C26843] +xref: DOID:1352 {source="MONDO:equivalentTo"} +xref: ICD9:478.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010254 {source="DOID:1352", source="MONDO:equivalentTo"} +xref: NCIT:C26843 {source="DOID:1352", source="MONDO:equivalentTo"} +xref: SCTID:7393007 {source="DOID:1352", source="MONDO:equivalentTo"} +xref: UMLS:C0030469 {source="DOID:1352", source="MONDO:equivalentTo", source="NCIT:C26843"} +is_a: MONDO:0002436 {source="DOID:1352", source="MESH:D010254"} ! nasal disorder +is_a: MONDO:0005087 ! respiratory system disorder +is_a: MONDO:0024654 ! skull disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +relationship: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch DOID:1352 +property_value: exactMatch http://identifiers.org/mesh/D010254 +property_value: exactMatch http://identifiers.org/snomedct/7393007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030469 +property_value: exactMatch NCIT:C26843 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001740 +name: cornea squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the cornea." [NCIT:P378] +synonym: "cornea epidermoid carcinoma" EXACT [NCIT:C4552] +synonym: "cornea squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4552] +synonym: "corneal epidermoid carcinoma" EXACT [DOID:13538, NCIT:C4552] +synonym: "corneal squamous cell carcinoma" EXACT [NCIT:C4552] +synonym: "epidermoid carcinoma of cornea" EXACT [NCIT:C4552] +synonym: "epidermoid carcinoma of the cornea" EXACT [NCIT:C4552] +synonym: "squamous cell carcinoma of cornea" EXACT [DOID:13538, NCIT:C4552] +synonym: "squamous cell carcinoma of the cornea" EXACT [NCIT:C4552] +xref: DOID:13538 {source="MONDO:equivalentTo"} +xref: NCIT:C4552 {source="DOID:13538", source="MONDO:equivalentTo"} +xref: SCTID:255008003 {source="DOID:13538", source="MONDO:equivalentTo"} +xref: UMLS:C0346366 {source="DOID:13538", source="MONDO:equivalentTo", source="NCIT:C4552"} +is_a: MONDO:0002466 {source="MONDO:Redundant", source="NCIT:C4552"} ! eye carcinoma +is_a: MONDO:0003802 {source="DOID:13538", source="MONDO:Redundant", source="NCIT:C4552"} ! cornea cancer +is_a: MONDO:0010150 {source="MONDO:Redundant"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch DOID:13538 +property_value: exactMatch http://identifiers.org/snomedct/255008003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346366 +property_value: exactMatch NCIT:C4552 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0001743 +name: paranasal sinus lymphoma +def: "A lymphoma that arises from the paranasal sinus. Representative examples include diffuse large B-cell lymphoma and extranodal NK/T-cell lymphoma, nasal type." [NCIT:C6068] +synonym: "accessory sinus lymphoma" EXACT [NCIT:C6068] +synonym: "lymphoma of accessory sinus" EXACT [DOID:1355, NCIT:C6068] +synonym: "lymphoma of paranasal sinus" EXACT [DOID:1355] +synonym: "lymphoma of the accessory sinus" EXACT [NCIT:C6068] +synonym: "lymphoma of the paranasal sinus" EXACT [NCIT:C6068] +synonym: "paranasal sinus lymphoma" EXACT [MONDO:patterns/location] +synonym: "primary paranasal sinus lymphoma" EXACT [NCIT:C6068] +xref: DOID:1355 {source="MONDO:equivalentTo"} +xref: NCIT:C6068 {source="DOID:1355", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1335339 {source="DOID:1355", source="NCIT:C6068", source="MONDO:equivalentTo"} +is_a: MONDO:0017814 ! primary bone lymphoma +is_a: MONDO:0020669 ! paranasal sinus cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch DOID:1355 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335339 +property_value: exactMatch NCIT:C6068 +property_value: excluded_subClassOf MONDO:0000380 {source="DOID:1355"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001748 +name: maxillary sinus carcinoma +def: "A carcinoma that arises from the maxillary sinus. Representative examples include squamous cell carcinoma, adenocarcinoma, and adenoid cystic carcinoma." [NCIT:C9332] +synonym: "cancer of maxillary sinus" EXACT [MONDO:patterns/cancer] +synonym: "carcinoma of maxillary sinus" EXACT [MONDO:patterns/carcinoma] +synonym: "malignant maxillary sinus neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3540] +synonym: "malignant maxillary sinus tumor" EXACT [NCIT:C3540] +synonym: "malignant neoplasm of antrum" EXACT [DOID:1357] +synonym: "malignant neoplasm of maxillary sinus" EXACT [MONDO:patterns/cancer, NCIT:C3540] +synonym: "malignant neoplasm of the maxillary sinus" EXACT [NCIT:C3540] +synonym: "malignant tumor of maxillary sinus" EXACT [NCIT:C3540] +synonym: "malignant tumor of the maxillary sinus" EXACT [DOID:1357, NCIT:C3540] +synonym: "maxillary sinus cancer" EXACT [MONDO:patterns/location, NCIT:C9332] +synonym: "maxillary sinus carcinoma" EXACT [NCIT:C9332] +xref: DOID:1357 {source="MONDO:equivalentTo"} +xref: ICD9:160.2 {source="DOID:1357", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3540 {source="DOID:1357", source="MONDO:equivalentTo"} +xref: NCIT:C9332 {source="DOID:1357", source="MONDO:equivalentTo"} +xref: SCTID:363425008 {source="DOID:1357", source="MONDO:equivalentTo"} +is_a: MONDO:0000380 {source="DOID:1357", source="MONDO:Redundant", source="NCIT:C9332"} ! paranasal sinus carcinoma +is_a: MONDO:0002131 ! jaw cancer +is_a: MONDO:0006181 ! digestive system carcinoma +is_a: MONDO:0006850 {source="MONDO:Redundant", source="NCIT:C3540", source="NCIT:C9332/inferred"} ! maxillary sinus neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001764 ! maxillary sinus +property_value: exactMatch DOID:1357 +property_value: exactMatch http://identifiers.org/snomedct/363425008 +property_value: exactMatch NCIT:C3540 +property_value: exactMatch NCIT:C9332 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0001756 +name: frontal sinus cancer +def: "A malignant neoplasm involving the frontal sinus." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of frontal sinus" EXACT [MONDO:patterns/cancer] +synonym: "frontal sinus cancer" EXACT [MONDO:patterns/location] +synonym: "malignant frontal sinus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant frontal sinus tumor" EXACT [NCIT:C3542] +synonym: "malignant neoplasm of frontal sinus" EXACT [DOID:1360, ICD9CM:160.4, MONDO:patterns/cancer, MTH:U001261] +synonym: "malignant neoplasm of the frontal sinus" EXACT [NCIT:C3542] +synonym: "malignant tumor of frontal sinus" EXACT [NCIT:C3542] +synonym: "malignant tumor of the frontal sinus" EXACT [DOID:1360, NCIT:C3542] +xref: DOID:1360 {source="MONDO:equivalentTo"} +xref: ICD10CM:C31.2 {source="MONDO:equivalentTo", source="DOID:1360"} +xref: ICD9:160.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1360"} +xref: NCIT:C3542 {source="MONDO:equivalentTo", source="DOID:1360"} +xref: SCTID:363427000 {source="MONDO:equivalentTo", source="DOID:1360"} +xref: UMLS:C0153478 {source="MONDO:equivalentTo", source="NCIT:C3542", source="DOID:1360"} +is_a: MONDO:0000380 {source="DOID:1360", source="MONDO:Entailed"} ! paranasal sinus carcinoma +is_a: MONDO:0001757 {source="MONDO:Redundant", source="NCIT:C3542"} ! frontal sinus neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001760 ! frontal sinus +property_value: exactMatch DOID:1360 +property_value: exactMatch http://identifiers.org/snomedct/363427000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153478 +property_value: exactMatch https://icd.codes/icd10cm/C31.2 +property_value: exactMatch NCIT:C3542 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001757 +name: frontal sinus neoplasm +alt_id: MONDO:0021214 +def: "A benign or malignant neoplasm that affects the frontal sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:P378] +synonym: "frontal sinus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "frontal sinus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4419] +synonym: "neoplasm of frontal sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C4419] +synonym: "neoplasm of the frontal sinus" EXACT [NCIT:C4419] +synonym: "tumor of frontal sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C4419] +synonym: "tumor of the frontal sinus" EXACT [DOID:1361, NCIT:C4419] +xref: DOID:1361 {source="MONDO:equivalentTo"} +xref: NCIT:C4419 {source="DOID:1361", source="MONDO:equivalentTo"} +xref: SCTID:126678005 {source="DOID:1361", source="MONDO:equivalentTo"} +xref: UMLS:C0345672 {source="DOID:1361", source="NCIT:C4419", source="MONDO:equivalentTo"} +is_a: MONDO:0005289 {source="DOID:1361", source="MONDO:Redundant", source="NCIT:C4419"} ! paranasal sinus neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001760 ! frontal sinus +relationship: disease_has_location UBERON:0001760 ! frontal sinus +property_value: exactMatch DOID:1361 +property_value: exactMatch http://identifiers.org/snomedct/126678005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345672 +property_value: exactMatch NCIT:C4419 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001763 +name: ethmoid sinus cancer +def: "A malignant neoplasm involving the ethmoid sinus." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of ethmoid sinus" EXACT [MONDO:patterns/cancer] +synonym: "ethmoid sinus cancer" EXACT [MONDO:patterns/location] +synonym: "malignant ethmoid sinus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant ethmoid sinus tumor" EXACT [NCIT:C3541] +synonym: "malignant ethmoidal sinus neoplasm" EXACT [NCIT:C3541] +synonym: "malignant ethmoidal sinus tumor" EXACT [NCIT:C3541] +synonym: "malignant neoplasm of ethmoid sinus" EXACT [MONDO:patterns/cancer, NCIT:C3541] +synonym: "malignant neoplasm of ethmoidal sinus" EXACT [DOID:1363, ICD9CM:160.3] +synonym: "malignant neoplasm of the ethmoid sinus" EXACT [NCIT:C3541] +synonym: "malignant neoplasm of the ethmoidal sinus" EXACT [NCIT:C3541] +synonym: "malignant tumor of ethmoid sinus" EXACT [NCIT:C3541] +synonym: "malignant tumor of ethmoidal sinus" EXACT [DOID:1363, NCIT:C3541] +synonym: "malignant tumor of the ethmoid sinus" EXACT [NCIT:C3541] +synonym: "malignant tumor of the ethmoidal sinus" EXACT [NCIT:C3541] +xref: DOID:1363 {source="MONDO:equivalentTo"} +xref: ICD10CM:C31.1 {source="DOID:1363", source="MONDO:equivalentTo"} +xref: ICD9:160.3 {source="DOID:1363", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3541 {source="DOID:1363", source="MONDO:equivalentTo"} +xref: SCTID:363426009 {source="DOID:1363", source="MONDO:equivalentTo"} +xref: UMLS:C0153477 {source="DOID:1363", source="MONDO:equivalentTo", source="NCIT:C3541"} +is_a: MONDO:0000380 {source="DOID:1363", source="MONDO:Entailed"} ! paranasal sinus carcinoma +is_a: MONDO:0001764 {source="MONDO:Redundant", source="NCIT:C3541"} ! ethmoidal sinus neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002453 ! ethmoid sinus +property_value: exactMatch DOID:1363 +property_value: exactMatch http://identifiers.org/snomedct/363426009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153477 +property_value: exactMatch https://icd.codes/icd10cm/C31.1 +property_value: exactMatch NCIT:C3541 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001764 +name: ethmoidal sinus neoplasm +alt_id: MONDO:0021215 +def: "A benign or malignant neoplasm that affects the ethmoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:C4416] +synonym: "ethmoid sinus neoplasm" EXACT [NCIT:C4416] +synonym: "ethmoid sinus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "ethmoid sinus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4416] +synonym: "ethmoidal sinus neoplasm" EXACT [NCIT:C4416] +synonym: "ethmoidal sinus tumor" EXACT [NCIT:C4416] +synonym: "neoplasm of ethmoid sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C4416] +synonym: "neoplasm of ethmoidal sinus" EXACT [NCIT:C4416] +synonym: "neoplasm of the ethmoid sinus" EXACT [NCIT:C4416] +synonym: "neoplasm of the ethmoidal sinus" EXACT [NCIT:C4416] +synonym: "tumor of ethmoid sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C4416] +synonym: "tumor of ethmoidal sinus" EXACT [DOID:1364, NCIT:C4416] +synonym: "tumor of the ethmoid sinus" EXACT [NCIT:C4416] +synonym: "tumor of the ethmoidal sinus" EXACT [NCIT:C4416] +xref: DOID:1364 {source="MONDO:equivalentTo"} +xref: NCIT:C4416 {source="DOID:1364", source="MONDO:equivalentTo"} +xref: SCTID:126677000 {source="DOID:1364", source="MONDO:equivalentTo"} +xref: UMLS:C0345668 {source="DOID:1364", source="MONDO:equivalentTo", source="NCIT:C4416"} +is_a: MONDO:0005289 {source="DOID:1364", source="MONDO:Redundant", source="NCIT:C4416"} ! paranasal sinus neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002453 ! ethmoid sinus +relationship: disease_has_location UBERON:0002453 ! ethmoid sinus +property_value: exactMatch DOID:1364 +property_value: exactMatch http://identifiers.org/snomedct/126677000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345668 +property_value: exactMatch NCIT:C4416 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001806 +name: vaginal squamous tumor +def: "A benign or malignant neoplasm that arises from the squamous epithelium of the vagina. Representative examples include condyloma acuminatum, squamous papilloma, and squamous cell carcinoma." [NCIT:P378] +synonym: "vagina squamous cell neoplasm" EXACT [MONDO:patterns/location] +synonym: "vaginal squamous neoplasm" EXACT [NCIT:C40242] +synonym: "vaginal squamous tumor" EXACT [NCIT:C40242] +xref: DOID:138 {source="MONDO:equivalentTo"} +xref: NCIT:C40242 {source="DOID:138", source="MONDO:equivalentTo"} +xref: UMLS:C1519931 {source="DOID:138", source="MONDO:equivalentTo", source="NCIT:C40242"} +is_a: MONDO:0002532 {source="MONDO:Redundant", source="NCIT:C40242"} ! squamous cell neoplasm +is_a: MONDO:0021050 {source="MONDO:Redundant", source="NCIT:C40242"} ! vaginal neoplasm +intersection_of: MONDO:0002532 ! squamous cell neoplasm +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch DOID:138 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519931 +property_value: exactMatch NCIT:C40242 + +[Term] +id: MONDO:0001810 +name: hypoglossal nerve disorder +def: "A disease involving the hypoglossal nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of hypoglossal nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of hypoglossal nerve" EXACT [] +synonym: "disorder of 12th nerve" EXACT [DOID:13814] +synonym: "disorder of hypoglossal [12th] nerve" EXACT [DOID:13814, ICD9CM:352.5] +synonym: "disorder of hypoglossal nerve" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the XII nerve" EXACT [NCIT:C26954] +synonym: "disorder of XII nerve" EXACT [DOID:13814, NCIT:C26954] +synonym: "hypoglossal nerve disease" EXACT [MONDO:patterns/location] +synonym: "hypoglossal nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "hypoglossal nerve disorder" EXACT [NCIT:C26954] +synonym: "twelfth nerve disorder" EXACT [NCIT:C26954] +xref: DOID:13814 {source="MONDO:equivalentTo"} +xref: ICD9:352.5 {source="DOID:13814", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D020437 {source="DOID:13814", source="MONDO:equivalentTo"} +xref: NCIT:C26954 {source="DOID:13814", source="MONDO:equivalentTo"} +xref: SCTID:24777009 {source="DOID:13814", source="MONDO:equivalentTo"} +xref: UMLS:C0152181 {source="DOID:13814", source="MONDO:equivalentTo", source="NCIT:C26954"} +is_a: MONDO:0003569 {source="DOID:13814/inferred", source="MESH:D020437", source="MONDO:Redundant", source="NCIT:C26954"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001650 ! hypoglossal nerve +relationship: disease_has_location UBERON:0001650 ! hypoglossal nerve +property_value: exactMatch DOID:13814 +property_value: exactMatch http://identifiers.org/mesh/D020437 +property_value: exactMatch http://identifiers.org/snomedct/24777009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152181 +property_value: exactMatch NCIT:C26954 +property_value: excluded_subClassOf MONDO:0002639 {source="DOID:13814"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001816 +name: scleroperikeratitis +synonym: "scleritis with corneal involvement" EXACT [DOID:13861, ICD9CM:379.05] +xref: DOID:13861 {source="MONDO:equivalentTo"} +xref: ICD9:379.05 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13861"} +xref: SCTID:42574005 {source="MONDO:equivalentTo", source="DOID:13861"} +xref: UMLS:C0155355 {source="MONDO:equivalentTo", source="DOID:13861"} +is_a: MONDO:0001718 {source="DOID:13861"} ! scleritis +is_a: MONDO:0003085 ! keratitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000964 ! cornea +intersection_of: disease_has_inflammation_site UBERON:0001773 ! sclera +relationship: disease_has_inflammation_site UBERON:0001773 ! sclera +property_value: exactMatch DOID:13861 +property_value: exactMatch http://identifiers.org/snomedct/42574005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155355 + +[Term] +id: MONDO:0001818 +name: facial neuralgia +def: "Neuralgic syndromes which feature chronic or recurrent facial pain as the primary manifestation of disease. Disorders of the trigeminal and facial nerves are frequently associated with these conditions." [MESH:D005156] +synonym: "facial nerve neuralgia" EXACT [MONDO:patterns/location] +synonym: "neuralgia of facial nerve" EXACT [MONDO:design_pattern] +xref: DOID:13865 {source="MONDO:equivalentTo"} +xref: ICD9:351.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005156 {source="DOID:13865", source="MONDO:equivalentTo"} +xref: SCTID:4151000119102 {source="DOID:13865", source="MONDO:equivalentTo"} +is_a: MONDO:0002098 {source="DOID:13865", source="MESH:D005156", source="MONDO:Redundant"} ! facial nerve disorder +is_a: MONDO:0016374 ! cranial neuralgia +intersection_of: MONDO:0021667 ! neuralgia +intersection_of: disease_has_location UBERON:0001647 ! facial nerve +property_value: exactMatch DOID:13865 +property_value: exactMatch http://identifiers.org/mesh/D005156 +property_value: exactMatch http://identifiers.org/snomedct/4151000119102 + +[Term] +id: MONDO:0001829 +name: lumbosacral plexus lesion +def: "A nerve plexus disease that involves the lumbosacral nerve plexus." [MONDO:design_pattern] +synonym: "lumbosacral nerve plexus nerve plexus disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lumbosacral plexus lesions" EXACT [DOID:13913, ICD9CM:353.1] +synonym: "nerve plexus disease of lumbosacral nerve plexus" EXACT [MONDO:design_pattern] +xref: DOID:13913 {source="MONDO:equivalentTo"} +xref: ICD9:353.1 {source="DOID:13913", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:4062006 {source="DOID:13913", source="MONDO:equivalentTo"} +xref: UMLS:C0154735 {source="DOID:13913", source="MONDO:equivalentTo"} +is_a: MONDO:0024432 {source="MONDO:Redundant"} ! nerve plexus disorder +intersection_of: MONDO:0024432 ! nerve plexus disorder +intersection_of: disease_has_location UBERON:0001815 ! lumbosacral nerve plexus +relationship: disease_has_location UBERON:0001815 ! lumbosacral nerve plexus +property_value: exactMatch DOID:13913 +property_value: exactMatch http://identifiers.org/snomedct/4062006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154735 + +[Term] +id: MONDO:0001834 +name: visual pathway disorder +def: "A disorder of the neural pathway from the optic nerve to the visual cortex." [NCIT:C35342] +comment: Editor note: see notes on uberon class, different sources are more or less inclusive on where the ends of the tract/pathway are. DO is very inclusive and includes entire visual cortex; NCIT does not include any subclasses. Consider using a more generic concept than optic tract +synonym: "disease of optic tract" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of optic tract" EXACT [] +synonym: "disorder of optic tract" EXACT [MONDO:patterns/location_top] +synonym: "optic tract disease" EXACT [MONDO:patterns/location] +synonym: "optic tract disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "optic tract disorder" RELATED [] +synonym: "visual pathway disorder" EXACT [NCIT:C35342] +xref: DOID:1393 {source="MONDO:equivalentTo"} +xref: ICD10CM:H47.9 {source="DOID:1393", source="MONDO:equivalentToUnspecified"} +xref: NCIT:C35342 {source="MONDO:equivalentTo", source="DOID:1393"} +xref: SCTID:54767005 {source="MONDO:equivalentTo", source="DOID:1393"} +xref: SCTID:95776004 {source="MONDO:equivalentTo"} +xref: UMLS:C0155287 {source="NCIT:C35342", source="MONDO:equivalentTo", source="DOID:1393"} +is_a: MONDO:0005560 ! brain disorder +is_a: MONDO:0021084 {source="NCIT:C35342"} ! vision disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001908 ! optic tract +relationship: disease_has_location UBERON:0001908 ! optic tract +property_value: exactMatch DOID:1393 +property_value: exactMatch http://identifiers.org/snomedct/54767005 +property_value: exactMatch http://identifiers.org/snomedct/95776004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155287 +property_value: exactMatch https://icd.codes/icd10cm/H47.9 +property_value: exactMatch NCIT:C35342 +property_value: excluded_subClassOf MONDO:0005328 {source="DOID:1393"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001852 +name: small intestine lymphoma +def: "A non-Hodgkin or Hodgkin lymphoma that arises from the small intestine." [NCIT:P378] +synonym: "lymphoma of small bowel" EXACT [NCIT:C4007] +synonym: "lymphoma of small intestine" EXACT [NCIT:C4007] +synonym: "lymphoma of the small bowel" EXACT [NCIT:C4007] +synonym: "lymphoma of the small intestine" EXACT [NCIT:C4007] +synonym: "primary small intestinal lymphoma" EXACT [NCIT:C4007] +synonym: "small bowel lymphoma" EXACT [NCIT:C4007] +synonym: "small intestinal lymphoma" EXACT [DOID:13996, NCIT:C4007] +synonym: "small intestine lymphoma" EXACT [MONDO:patterns/location, NCIT:C4007] +xref: DOID:13996 {source="MONDO:equivalentTo"} +xref: ICD9:202.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4007 {source="MONDO:equivalentTo", source="DOID:13996"} +xref: SCTID:449074003 {source="MONDO:equivalentTo", source="DOID:13996"} +xref: UMLS:C0278805 {source="MONDO:equivalentTo", source="NCIT:C4007", source="DOID:13996"} +is_a: MONDO:0000956 {source="DOID:13996", source="MONDO:Redundant", source="NCIT:C4007"} ! small intestine cancer +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C4007"} ! gastrointestinal lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:13996 +property_value: exactMatch http://identifiers.org/snomedct/449074003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278805 +property_value: exactMatch NCIT:C4007 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001854 +name: lacrimal apparatus disorder +def: "A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus." [NCIT:C26809] +synonym: "disease of lacrimal apparatus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lacrimal apparatus" EXACT [] +synonym: "disorder of lacrimal apparatus" EXACT [MONDO:patterns/location_top] +synonym: "disorder of lacrimal system" EXACT [NCIT:C26809] +synonym: "lachrymal system disorders" RELATED [] +synonym: "lacrimal apparatus disease" EXACT [MONDO:patterns/location] +synonym: "lacrimal apparatus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lacrimal system disease" EXACT [MONDO:0021628] +synonym: "lacrimal system disorder" EXACT [NCIT:C26809] +xref: DOID:1400 {source="MONDO:equivalentTo"} +xref: ICD9:375 {source="DOID:1400"} +xref: ICD9:375.69 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:375.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:375.9 {source="MONDO:equivalentTo", source="DOID:1400", source="MONDO:i2s"} +xref: MESH:D007766 {source="MONDO:equivalentTo", source="DOID:1400"} +xref: NCIT:C26809 {source="MONDO:equivalentTo", source="DOID:1400"} +xref: SCTID:31053003 {source="MONDO:equivalentTo", source="DOID:1400"} +is_a: MONDO:0000462 ! eye adnexa disorder +is_a: MONDO:0005328 {source="DOID:1400", source="MONDO:Entailed", source="NCIT:C26809"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001750 ! lacrimal apparatus +relationship: disease_has_location UBERON:0001750 ! lacrimal apparatus +property_value: exactMatch DOID:1400 +property_value: exactMatch http://identifiers.org/mesh/D007766 +property_value: exactMatch http://identifiers.org/snomedct/31053003 +property_value: exactMatch NCIT:C26809 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001858 +name: Tietze syndrome +def: "Idiopathic painful nonsuppurative swellings of one or more costal cartilages, especially of the second rib. The anterior chest pain may mimic that of coronary artery disease." [MESH:D013991] +synonym: "Chondropathia tuberosa" RELATED [GARD:0010100] +synonym: "Costalchondritis" EXACT [DOID:14021] +synonym: "costochondral joint syndromic disease" EXACT [MONDO:patterns/location] +synonym: "costochondral junction syndrome" EXACT [DOID:14021] +synonym: "Costochondritis" EXACT [DOID:14021] +synonym: "slipping rib syndrome" EXACT [DOID:14021] +synonym: "syndromic disease of costochondral joint" EXACT [MONDO:design_pattern] +synonym: "Tietze syndrome" EXACT [DOID:14021] +synonym: "Tietze's disease" EXACT [DOID:14021, ICD9CM:733.6] +synonym: "Tietze's syndrome" EXACT [doi:10.1093/jama/9780195176339.003.0016, MONDO:LexicalVariant] +xref: DOID:14021 {source="MONDO:equivalentTo"} +xref: GARD:0010100 {source="MONDO:equivalentTo", source="MONDO:shared-xref"} +xref: ICD9:733.6 {source="DOID:14021", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D013991 {source="DOID:14021", source="MONDO:equivalentTo"} +xref: NCIT:C168333 {source="MONDO:equivalentTo"} +xref: SCTID:30128009 {source="DOID:14021", source="MONDO:equivalentTo"} +xref: UMLS:C0040213 {source="DOID:14021", source="MONDO:equivalentTo"} +is_a: MONDO:0002254 {source="DOID:14021", source="MONDO:Redundant"} ! syndromic disease +is_a: MONDO:0006816 ! arthropathy +intersection_of: MONDO:0002254 ! syndromic disease +intersection_of: disease_has_location UBERON:0002293 ! costochondral joint +relationship: disease_has_location UBERON:0002293 ! costochondral joint +property_value: exactMatch DOID:14021 +property_value: exactMatch http://identifiers.org/mesh/D013991 +property_value: exactMatch http://identifiers.org/snomedct/30128009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040213 +property_value: exactMatch NCIT:C168333 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0001869 +name: paraurethral gland cancer +def: "A malignant neoplasm involving the paraurethral gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of paraurethral gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of paraurethral gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant paraurethral gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of paraurethral gland" EXACT [DOID:14059] +synonym: "malignant tumor of the paraurethral gland" EXACT [DOID:14059, NCIT:C3561] +synonym: "paraurethral gland cancer" EXACT [MONDO:patterns/location] +xref: DOID:14059 {source="MONDO:equivalentTo"} +xref: ICD9:189.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14059"} +xref: SCTID:363460002 {source="MONDO:equivalentTo", source="DOID:14059"} +xref: UMLS:C0153621 {source="MONDO:equivalentTo", source="DOID:14059"} +is_a: MONDO:0001528 {source="MONDO:Redundant"} ! vulva cancer +is_a: MONDO:0002219 {source="MONDO:Redundant"} ! paraurethral gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0010145 ! paraurethral gland +property_value: exactMatch DOID:14059 +property_value: exactMatch http://identifiers.org/snomedct/363460002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153621 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001873 +name: geniculate ganglionitis +def: "Diseases of the facial nerve or nuclei. Pontine disorders may affect the facial nuclei or nerve fascicle. The nerve may be involved intracranially, along its course through the petrous portion of the temporal bone, or along its extracranial course. Clinical manifestations include facial muscle weakness, loss of taste from the anterior tongue, hyperacusis, and decreased lacrimation." [MESH:D005155] +synonym: "geniculate ganglion inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "geniculate ganglionitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of geniculate ganglion" EXACT [] +xref: DOID:14075 {source="MONDO:equivalentTo"} +xref: ICD10CM:G51.1 {source="MONDO:equivalentTo", source="DOID:14075"} +xref: ICD9:351.1 {source="MONDO:equivalentTo", source="DOID:14075", source="MONDO:i2s"} +xref: SCTID:72839009 {source="MONDO:equivalentTo", source="DOID:14075"} +xref: UMLS:C0017407 {source="MONDO:equivalentTo", source="DOID:14075"} +is_a: MONDO:0002098 {source="DOID:14075", source="ICD10CM:G51.1"} ! facial nerve disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0021260 ! sensory ganglionopathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001700 ! geniculate ganglion +relationship: disease_has_inflammation_site UBERON:0001700 ! geniculate ganglion +property_value: exactMatch DOID:14075 +property_value: exactMatch http://identifiers.org/snomedct/72839009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017407 +property_value: exactMatch https://icd.codes/icd10cm/G51.1 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0001876 +name: renal artery atheroma +def: "A atherosclerosis that involves the renal artery." [MONDO:patterns/location] +synonym: "atherosclerosis of renal artery" EXACT [DOID:14092, ICD9CM:440.1] +synonym: "renal artery atherosclerosis" EXACT [MONDO:patterns/location] +synonym: "renal atherosclerosis" EXACT [DOID:14092] +xref: DOID:14092 {source="MONDO:equivalentTo"} +xref: ICD10CM:I70.1 {source="DOID:14092", source="MONDO:equivalentTo"} +xref: ICD9:440.1 {source="DOID:14092", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:45281005 {source="DOID:14092", source="MONDO:equivalentTo"} +xref: UMLS:C0155734 {source="DOID:14092", source="MONDO:equivalentTo"} +is_a: MONDO:0000980 ! aortic atherosclerosis +is_a: MONDO:0002286 {source="DOID:14092"} ! renal artery disease +intersection_of: MONDO:0005311 ! atherosclerosis +intersection_of: disease_has_location UBERON:0001184 ! renal artery +property_value: exactMatch DOID:14092 +property_value: exactMatch http://identifiers.org/snomedct/45281005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155734 +property_value: exactMatch https://icd.codes/icd10cm/I70.1 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0001879 +name: anus cancer +def: "A malignant neoplasm involving the anus" [https://orcid.org/0000-0002-6601-2165] +synonym: "anus cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of anus" EXACT [MONDO:patterns/cancer] +synonym: "malignant anal neoplasm" EXACT [NCIT:C7379] +synonym: "malignant anal tumor" EXACT [DOID:14110, NCIT:C7379] +synonym: "malignant anus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of anus" EXACT [MONDO:patterns/cancer, NCIT:C7379] +synonym: "malignant neoplasm of the anus" EXACT [NCIT:C7379] +synonym: "malignant tumor of anus" EXACT [NCIT:C7379] +synonym: "malignant tumor of the anus" EXACT [NCIT:C7379] +xref: DOID:14110 {source="MONDO:equivalentTo"} +xref: GARD:0009300 {source="MONDO:equivalentTo"} +xref: ICD9:154.2 {source="MONDO:relatedTo", source="DOID:14110"} +xref: ICD9:154.3 {source="DOID:14110"} +xref: NCIT:C7379 {source="MONDO:equivalentTo", source="DOID:14110"} +is_a: MONDO:0003046 {source="MONDO:Redundant", source="NCIT:C7379"} ! anus neoplasm +is_a: MONDO:0006519 ! rectal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:14110 +property_value: exactMatch NCIT:C7379 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001884 +name: abducens nerve neoplasm +def: "A neoplasm involving a abducens nerve." [MONDO:patterns/neoplasm] +synonym: "abducens nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "abducens nerve neoplasms" EXACT [NCIT:C5826] +synonym: "abducens nerve tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "abducens nerve tumors" EXACT [NCIT:C5826] +synonym: "neoplasm of abducens nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of sixth cranial nerve" EXACT [NCIT:C5826] +synonym: "neoplasm of the abducens nerve" EXACT [NCIT:C5826] +synonym: "neoplasm of the sixth cranial nerve" EXACT [NCIT:C5826] +synonym: "sixth cranial nerve neoplasm" EXACT [NCIT:C5826] +synonym: "sixth cranial nerve neoplasms" EXACT [NCIT:C5826] +synonym: "sixth cranial nerve tumor" EXACT [NCIT:C5826] +synonym: "sixth cranial nerve tumors" EXACT [NCIT:C5826] +synonym: "tumor of abducens nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5826] +synonym: "tumor of sixth cranial nerve" EXACT [NCIT:C5826] +synonym: "tumor of the abducens nerve" EXACT [NCIT:C5826] +synonym: "tumor of the sixth cranial nerve" EXACT [NCIT:C5826] +synonym: "VIth cranial nerve neoplasms" EXACT [NCIT:C5826] +synonym: "VIth cranial nerve tumors" EXACT [DOID:14125, NCIT:C5826] +xref: DOID:14125 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5826 {source="MONDO:equivalentTo", source="DOID:14125"} +xref: SCTID:126972009 {source="MONDO:equivalentTo", source="DOID:14125"} +xref: UMLS:C1263898 {source="MONDO:equivalentTo", source="DOID:14125", source="NCIT:C5826"} +is_a: MONDO:0002633 {source="DOID:14125", source="MONDO:Redundant", source="NCIT:C5826"} ! cranial nerve neoplasm +is_a: MONDO:0020594 ! abducens nerve disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001646 ! abducens nerve +property_value: exactMatch DOID:14125 +property_value: exactMatch http://identifiers.org/snomedct/126972009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263898 +property_value: exactMatch NCIT:C5826 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0001888 +name: anus lymphoma +def: "A usually large cell non-Hodgkin lymphoma of B-cell phenotype, arising from the anus. Lymphomas originating from the anal region are rare in the general population, but they are seen with a higher frequency in HIV-positive patients, particularly homosexual men." [NCIT:P378] +synonym: "anal lymphoma" EXACT [NCIT:C5601] +synonym: "anus lymphoma" EXACT [MONDO:patterns/location] +synonym: "lymphoma of anus" EXACT [DOID:14139, NCIT:C5601] +synonym: "lymphoma of the anus" EXACT [NCIT:C5601] +synonym: "primary anal lymphoma" EXACT [NCIT:C5601] +xref: DOID:14139 {source="MONDO:equivalentTo"} +xref: NCIT:C5601 {source="MONDO:equivalentTo", source="DOID:14139"} +xref: UMLS:C1332268 {source="MONDO:equivalentTo", source="NCIT:C5601", source="DOID:14139"} +is_a: MONDO:0001879 {source="DOID:14139", source="MONDO:Redundant", source="NCIT:C5601"} ! anus cancer +is_a: MONDO:0002166 ! rectum lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:14139 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332268 +property_value: exactMatch NCIT:C5601 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001892 +name: spinal cord lymphoma +def: "A non-Hodgkin or Hodgkin lymphoma that arises in the spinal cord as a primary lesion." [NCIT:C5157] +synonym: "lymphoma of spinal cord" EXACT [NCIT:C5157] +synonym: "lymphoma of the spinal cord" EXACT [DOID:14150, NCIT:C5157] +synonym: "primary spinal cord lymphoma" EXACT [NCIT:C5157] +synonym: "spinal cord cancer" RELATED [DOID:14150] +synonym: "spinal cord lymphoma" EXACT [MONDO:patterns/location, NCIT:C5157] +xref: DOID:14150 {source="MONDO:equivalentTo"} +xref: NCIT:C5157 {source="DOID:14150", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1336044 {source="DOID:14150", source="MONDO:equivalentTo", source="NCIT:C5157"} +is_a: MONDO:0002571 {source="DOID:14150", source="MONDO:Redundant", source="NCIT:C5157"} ! primary central nervous system lymphoma +is_a: MONDO:0003544 {source="DOID:14150", source="MONDO:Redundant", source="NCIT:C5157"} ! spinal cord cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:14150 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336044 +property_value: exactMatch NCIT:C5157 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001898 +name: optic choroid disorder +def: "A disease involving the optic choroid." [https://orcid.org/0000-0002-6601-2165] +synonym: "choroid disease" RELATED [DOID:1417] +synonym: "choroid disorder" EXACT [NCIT:C34468] +synonym: "disease of optic choroid" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of optic choroid" EXACT [] +synonym: "disorder of optic choroid" EXACT [MONDO:patterns/location_top] +synonym: "optic choroid disease" EXACT [MONDO:patterns/location] +synonym: "optic choroid disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1417 {source="MONDO:equivalentTo"} +xref: ICD9:363.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:363.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1417"} +xref: MESH:D015862 {source="MONDO:equivalentTo", source="DOID:1417"} +xref: NCIT:C34468 {source="MONDO:equivalentTo", source="DOID:1417"} +xref: SCTID:128468007 {source="MONDO:equivalentTo"} +xref: UMLS:C0008521 {source="MONDO:equivalentTo", source="NCIT:C34468", source="DOID:1417"} +is_a: MONDO:0002661 {source="DOID:1417", source="MESH:D015862", source="MONDO:Redundant", source="NCIT:C34468"} ! uveal disorder +is_a: MONDO:0005552 ! ocular vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001776 ! optic choroid +relationship: disease_has_location UBERON:0001776 ! optic choroid +property_value: exactMatch DOID:1417 +property_value: exactMatch http://identifiers.org/mesh/D015862 +property_value: exactMatch http://identifiers.org/snomedct/128468007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008521 +property_value: exactMatch NCIT:C34468 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001912 +name: acute frontal sinusitis +def: "Acute form of frontal sinusitis." [MONDO:patterns/acute] +synonym: "frontal sinusitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:14225 {source="MONDO:equivalentTo"} +xref: ICD10CM:J01.1 {source="MONDO:equivalentTo", source="DOID:14225"} +xref: ICD9:461.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14225"} +xref: SCTID:91038008 {source="MONDO:equivalentTo", source="DOID:14225"} +xref: UMLS:C0155805 {source="MONDO:equivalentTo", source="DOID:14225"} +is_a: MONDO:0001121 {source="DOID:14225", source="MONDO:Redundant"} ! frontal sinusitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0001121 ! frontal sinusitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:14225 +property_value: exactMatch http://identifiers.org/snomedct/91038008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155805 +property_value: exactMatch https://icd.codes/icd10cm/J01.1 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0001926 +name: ureteral disorder +def: "A non-neoplastic or neoplastic disorder affecting the ureter." [NCIT:P378] +synonym: "disease of ureter" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ureter" EXACT [] +synonym: "disorder of ureter" EXACT [MONDO:patterns/location_top] +synonym: "ureter disease" EXACT [MONDO:patterns/location] +synonym: "ureter disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "ureter disorder" EXACT [NCIT:C27148] +synonym: "ureteric disease" EXACT [NCIT:C27148] +synonym: "ureteric disorder" EXACT [NCIT:C27148] +xref: DOID:1426 {source="MONDO:equivalentTo"} +xref: MESH:D014515 {source="MONDO:equivalentTo", source="DOID:1426"} +xref: NCIT:C27148 {source="MONDO:equivalentTo", source="DOID:1426"} +xref: SCTID:128073008 {source="MONDO:equivalentTo"} +xref: UMLS:C0041954 {source="MONDO:equivalentTo", source="DOID:1426"} +xref: UMLS:C0403608 {source="MONDO:equivalentTo"} +is_a: MONDO:0002118 {source="DOID:1426", source="MESH:D014515", source="MONDO:Redundant", source="NCIT:C27148"} ! urinary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000056 ! ureter +relationship: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:1426 +property_value: exactMatch http://identifiers.org/mesh/D014515 +property_value: exactMatch http://identifiers.org/snomedct/128073008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0041954 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0403608 +property_value: exactMatch NCIT:C27148 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001930 +name: acute cholangitis +def: "Cholangitis that is both sudden in onset and of a relatively short duration." [NCIT:P378] +synonym: "acute cholangitis" EXACT [DOID:14271, NCIT:C35334] +synonym: "cholangitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:14271 {source="MONDO:equivalentTo"} +xref: NCIT:C35334 {source="DOID:14271", source="MONDO:equivalentTo"} +xref: SCTID:6215006 {source="DOID:14271", source="MONDO:equivalentTo"} +xref: UMLS:C0267917 {source="DOID:14271", source="MONDO:equivalentTo", source="NCIT:C35334"} +is_a: MONDO:0004789 {source="DOID:14271", source="MONDO:Redundant", source="NCIT:C35334"} ! cholangitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004789 ! cholangitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:14271 +property_value: exactMatch http://identifiers.org/snomedct/6215006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267917 +property_value: exactMatch NCIT:C35334 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0001933 +name: endocrine pancreas disorder +def: "A disease involving the endocrine pancreas." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of endocrine pancreas" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of endocrine pancreas" EXACT [] +synonym: "disorder of endocrine pancreas" EXACT [MONDO:patterns/location_top] +synonym: "disorder of islets of langerhans" RELATED [] +synonym: "disorder of pancreatic islets" RELATED [] +synonym: "endocrine pancreas disease" EXACT [MONDO:patterns/location, NCIT:C27067] +synonym: "endocrine pancreas disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "endocrine pancreas disorder" EXACT [NCIT:C27067] +xref: DOID:1428 {source="MONDO:equivalentTo"} +xref: ICD9:251 {source="DOID:1428"} +xref: NCIT:C27067 {source="MONDO:equivalentTo"} +xref: SCTID:17346000 {source="MONDO:equivalentTo"} +xref: UMLS:C0271633 {source="NCIT:C27067", source="MONDO:equivalentTo"} +is_a: MONDO:0002356 {source="DOID:1428", source="MONDO:Redundant", source="NCIT:C27067"} ! pancreas disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000016 ! endocrine pancreas +relationship: disease_has_location UBERON:0000016 ! endocrine pancreas +property_value: exactMatch DOID:1428 +property_value: exactMatch http://identifiers.org/snomedct/17346000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271633 +property_value: exactMatch NCIT:C27067 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0001949 +name: acute thyroiditis +def: "Acute form of thyroiditis (disease)." [MONDO:patterns/acute] +synonym: "acute thyroiditis (disease)" EXACT [] +synonym: "thyroiditis (disease), acute" EXACT [MONDO:patterns/acute] +xref: DOID:14353 {source="MONDO:equivalentTo"} +xref: ICD10CM:E06.0 {source="MONDO:equivalentTo", source="DOID:14353"} +xref: ICD9:245.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14353"} +xref: SCTID:190293001 {source="MONDO:equivalentTo", source="DOID:14353"} +xref: UMLS:C0001360 {source="MONDO:equivalentTo", source="DOID:14353"} +is_a: MONDO:0004126 {source="DOID:14353", source="MONDO:Redundant"} ! thyroiditis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004126 ! thyroiditis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:14353 +property_value: exactMatch http://identifiers.org/snomedct/190293001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001360 +property_value: exactMatch https://icd.codes/icd10cm/E06.0 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0001952 +name: parietal lobe cancer +def: "A malignant neoplasm involving the parietal lobe" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of parietal lobe" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of parietal lobe" EXACT [DOID:14384, MONDO:patterns/cancer] +synonym: "malignant parietal lobe neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "parietal lobe cancer" EXACT [MONDO:patterns/location] +synonym: "parietal lobe neoplasm" RELATED [DOID:14384] +xref: DOID:14384 {source="MONDO:equivalentTo"} +xref: ICD10CM:C71.3 {source="DOID:14384", source="MONDO:equivalentTo"} +xref: ICD9:191.3 {source="DOID:14384", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363469001 {source="DOID:14384", source="MONDO:equivalentTo"} +xref: UMLS:C0153637 {source="DOID:14384", source="MONDO:equivalentTo"} +is_a: MONDO:0002731 {source="DOID:14384", source="MONDO:Redundant"} ! cerebral hemisphere cancer +is_a: MONDO:0021373 {source="MONDO:Redundant"} ! neoplasm of parietal lobe +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001872 ! parietal lobe +property_value: exactMatch DOID:14384 +property_value: exactMatch http://identifiers.org/snomedct/363469001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153637 +property_value: exactMatch https://icd.codes/icd10cm/C71.3 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001977 +name: ureteral lymphoma +def: "A lymphoma that involves the ureter." [MONDO:patterns/location] +synonym: "lymphoma of the ureter" EXACT [NCIT:C6175] +synonym: "lymphoma of ureter" EXACT [DOID:14489, NCIT:C6175] +synonym: "primary ureter lymphoma" EXACT [NCIT:C6175] +synonym: "ureter lymphoma" EXACT [MONDO:patterns/location, NCIT:C6175] +synonym: "ureteral lymphoma" EXACT [DOID:14489, NCIT:C6175] +xref: DOID:14489 {source="MONDO:equivalentTo"} +xref: NCIT:C6175 {source="MONDO:equivalentTo", source="DOID:14489"} +xref: UMLS:C1336876 {source="NCIT:C6175", source="MONDO:equivalentTo", source="DOID:14489"} +is_a: MONDO:0005062 {source="DOID:14489", source="MONDO:Redundant", source="NCIT:C6175/inferred"} ! lymphoma +is_a: MONDO:0008627 {source="DOID:14489", source="NCIT:C6175"} ! ureter cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:14489 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336876 +property_value: exactMatch NCIT:C6175 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0001991 +name: malignant cardiac germ cell tumor +def: "A rare malignant germ cell tumor that arises from the pericardium." [NCIT:C5371] +synonym: "malignant Cardiac germ cell neoplasm" EXACT [NCIT:C5371] +synonym: "malignant Cardiac germ cell tumor" EXACT [NCIT:C5371] +synonym: "malignant germ cell neoplasm of heart" EXACT [NCIT:C5371] +synonym: "malignant germ cell neoplasm of the heart" EXACT [NCIT:C5371] +synonym: "malignant germ cell tumor of heart" EXACT [NCIT:C5371] +synonym: "malignant germ cell tumor of the heart" EXACT [DOID:14535, NCIT:C5371] +synonym: "malignant heart germ cell neoplasm" EXACT [NCIT:C5371] +synonym: "malignant heart germ cell tumor" EXACT [NCIT:C5371] +xref: DOID:14535 {source="MONDO:equivalentTo"} +xref: NCIT:C5371 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:14535"} +xref: UMLS:C1334566 {source="NCIT:C5371", source="MONDO:equivalentTo", source="DOID:14535"} +is_a: MONDO:0001340 {source="DOID:14535", source="MONDO:Redundant", source="NCIT:C5371"} ! heart cancer +is_a: MONDO:0003113 ! extragonadal germ cell cancer +is_a: MONDO:0020589 ! cardiac germ cell tumor +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch DOID:14535 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334566 +property_value: exactMatch NCIT:C5371 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0001992 +name: rete testis adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the rete testis" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of rete testis" EXACT [DOID:14544, NCIT:C8955] +synonym: "adenocarcinoma of the rete testis" EXACT [DOID:14544, NCIT:C8955] +synonym: "carcinoma, rete testis, malignant" EXACT [NCIT:C8955] +synonym: "rete testis adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C8955] +xref: DOID:14544 {source="MONDO:equivalentTo"} +xref: NCIT:C8955 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:14544"} +xref: UMLS:C0863024 {source="MONDO:equivalentTo", source="NCIT:C8955", source="DOID:14544"} +is_a: MONDO:0003562 {source="DOID:14544", source="MONDO:Redundant", source="NCIT:C8955"} ! rete testis neoplasm +is_a: MONDO:0004970 {source="DOID:14544", source="MONDO:Redundant", source="NCIT:C8955"} ! adenocarcinoma +is_a: MONDO:0005447 ! testicular cancer +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0003959 ! rete testis +property_value: exactMatch DOID:14544 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0863024 +property_value: exactMatch NCIT:C8955 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0001993 +name: seminal vesicle adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the seminal vesicle" [https://orcid.org/0000-0002-6601-2165] +synonym: "seminal vesicle adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C39906] +xref: DOID:14545 {source="MONDO:equivalentTo"} +xref: NCIT:C39906 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:14545"} +xref: UMLS:C1519233 {source="MONDO:equivalentTo", source="NCIT:C39906", source="DOID:14545"} +is_a: MONDO:0002790 {source="MONDO:Redundant", source="NCIT:C39906"} ! seminal vesicle tumor +is_a: MONDO:0004970 {source="DOID:14545", source="MONDO:Redundant", source="NCIT:C39906"} ! adenocarcinoma +is_a: MONDO:0005447 ! testicular cancer +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000998 ! seminal vesicle +property_value: exactMatch DOID:14545 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519233 +property_value: exactMatch NCIT:C39906 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0001994 +name: sphenoidal sinus cancer +def: "A malignant neoplasm involving the sphenoidal sinus." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of sphenoidal sinus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sphenoid sinus" EXACT [NCIT:C3543] +synonym: "malignant neoplasm of sphenoidal sinus" EXACT [MONDO:patterns/cancer, NCIT:C3543] +synonym: "malignant neoplasm of the sphenoid sinus" EXACT [NCIT:C3543] +synonym: "malignant neoplasm of the sphenoidal sinus" EXACT [NCIT:C3543] +synonym: "malignant sphenoid sinus neoplasm" EXACT [NCIT:C3543] +synonym: "malignant sphenoid sinus tumor" EXACT [NCIT:C3543] +synonym: "malignant sphenoidal sinus neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3543] +synonym: "malignant sphenoidal sinus tumor" EXACT [NCIT:C3543] +synonym: "malignant tumor of sphenoid sinus" EXACT [NCIT:C3543] +synonym: "malignant tumor of sphenoidal sinus" EXACT [DOID:14546, NCIT:C3543] +synonym: "malignant tumor of the sphenoid sinus" EXACT [NCIT:C3543] +synonym: "malignant tumor of the sphenoidal sinus" EXACT [NCIT:C3543] +synonym: "sphenoidal sinus cancer" EXACT [MONDO:patterns/location] +xref: DOID:14546 {source="MONDO:equivalentTo"} +xref: ICD10CM:C31.3 {source="MONDO:equivalentTo", source="DOID:14546"} +xref: ICD9:160.5 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14546"} +xref: NCIT:C3543 {source="MONDO:equivalentTo", source="DOID:14546"} +xref: SCTID:363428005 {source="MONDO:equivalentTo", source="DOID:14546"} +xref: UMLS:C0153479 {source="MONDO:equivalentTo", source="NCIT:C3543", source="DOID:14546"} +is_a: MONDO:0000380 {source="DOID:14546", source="MONDO:Entailed"} ! paranasal sinus carcinoma +is_a: MONDO:0004047 {source="MONDO:Redundant", source="NCIT:C3543"} ! sphenoidal sinus neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001724 ! sphenoidal sinus +property_value: exactMatch DOID:14546 +property_value: exactMatch http://identifiers.org/snomedct/363428005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153479 +property_value: exactMatch https://icd.codes/icd10cm/C31.3 +property_value: exactMatch NCIT:C3543 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0001995 +name: sphenoid sinus squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal epithelial surface of the sphenoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis." [NCIT:C6066] +synonym: "epidermoid carcinoma of sphenoid sinus" EXACT [NCIT:C6066] +synonym: "epidermoid carcinoma of sphenoidal sinus" EXACT [NCIT:C6066] +synonym: "epidermoid carcinoma of the sphenoid sinus" EXACT [NCIT:C6066] +synonym: "epidermoid carcinoma of the sphenoidal sinus" EXACT [DOID:14547, NCIT:C6066] +synonym: "sphenoid sinus epidermoid carcinoma" EXACT [NCIT:C6066] +synonym: "sphenoid sinus squamous cell carcinoma" EXACT [NCIT:C6066] +synonym: "sphenoidal sinus epidermoid carcinoma" EXACT [NCIT:C6066] +synonym: "sphenoidal sinus squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6066] +synonym: "squamous cell carcinoma of sphenoid sinus" EXACT [NCIT:C6066] +synonym: "squamous cell carcinoma of sphenoidal sinus" EXACT [NCIT:C6066] +synonym: "squamous cell carcinoma of the sphenoid sinus" EXACT [NCIT:C6066] +synonym: "squamous cell carcinoma of the sphenoidal sinus" EXACT [NCIT:C6066] +xref: DOID:14547 {source="MONDO:equivalentTo"} +xref: NCIT:C6066 {source="DOID:14547", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:707355002 {source="MONDO:equivalentTo"} +xref: UMLS:C1336039 {source="DOID:14547", source="NCIT:C6066", source="MONDO:equivalentTo"} +is_a: MONDO:0001994 {source="DOID:14547", source="MONDO:Redundant", source="NCIT:C6066"} ! sphenoidal sinus cancer +is_a: MONDO:0044705 ! paranasal sinus squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001724 ! sphenoidal sinus +property_value: exactMatch DOID:14547 +property_value: exactMatch http://identifiers.org/snomedct/707355002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336039 +property_value: exactMatch NCIT:C6066 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002008 +name: labyrinthitis +def: "Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication." [NCIT:C128369, Wikipedia:Labyrinthitis] +comment: Note that DO has distinct classes for both labyrinthitis and otitis interna. These are generally regarded as synonyms. We intentionally make these two classes equivalent. However, the DO class may potentially represent the infectious form, although the sub/superclass relationships are inverted if this is the case. +synonym: "inflammation of internal ear" EXACT [] +synonym: "inner ear infection" RELATED [DOID:3930] +synonym: "internal ear inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "otitis interna" RELATED [Wikipedia:Labyrinthitis] +xref: DOID:1468 {source="MONDO:equivalentTo"} +xref: DOID:3930 {source="MONDO:equivalentTo"} +xref: ICD10CM:H83.0 {source="MONDO:equivalentTo", source="DOID:1468"} +xref: ICD9:386.3 {source="DOID:1468"} +xref: ICD9:386.30 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1468"} +xref: MESH:D007762 {source="MONDO:equivalentTo", source="DOID:1468"} +xref: NCIT:C128369 {source="MONDO:equivalentTo"} +xref: SCTID:23919004 {source="MONDO:equivalentTo", source="DOID:1468"} +xref: UMLS:C0022893 {source="MONDO:equivalentTo", source="NCIT:C128369", source="DOID:1468"} +is_a: MONDO:0002467 {source="DOID:1468/inferred", source="DOID:3930", source="ICD10CM:H83.0/inferred", source="MESH:D007762", source="MONDO:Redundant", source="NCIT:C128369"} ! inner ear disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001846 ! internal ear +relationship: disease_has_inflammation_site UBERON:0001846 ! internal ear +property_value: exactMatch DOID:1468 +property_value: exactMatch DOID:3930 +property_value: exactMatch http://identifiers.org/mesh/D007762 +property_value: exactMatch http://identifiers.org/snomedct/23919004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022893 +property_value: exactMatch https://icd.codes/icd10cm/H83.0 +property_value: exactMatch NCIT:C128369 +property_value: excluded_subClassOf MONDO:0002812 {source="DOID:1468"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002009 +name: major depressive disorder +def: "An episode of depression lasting two or more weeks without an intervening episode of mania." [NCIT:P378] +synonym: "major depression" EXACT [NCIT:C35094] +synonym: "major depressive disorder" EXACT [NCIT:C35094] +synonym: "major depressive disorder 1" BROAD [OMIM:608516, OMIM:genemap2] +synonym: "major depressive disorder 2" BROAD [OMIM:608516, OMIM:genemap2] +synonym: "major depressive disorder and accelerated response to antidepressant drug treatment" EXACT [OMIM:608516, OMIM:genemap2] +synonym: "major depressive disorder, response to citalopram therapy in" EXACT [OMIM:608516, OMIM:genemap2] +synonym: "recurrent major depression" EXACT [DOID:1470] +synonym: "seasonal affective disorder, susceptibility to" EXACT [OMIM:608516, OMIM:genemap2] +synonym: "single major depressive episode" EXACT [DOID:1470] +synonym: "unipolar depression" EXACT [MONDO:0005263] +synonym: "unipolar depression, susceptibility to" EXACT [OMIM:608516, OMIM:genemap2] +xref: DOID:1470 {source="MONDO:equivalentTo", xref="EFO:0003761"} +xref: DOID:2848 {source="EFO:0003761", source="MONDO:directSiblingOf"} +xref: EFO:0003761 {source="MONDO:equivalentTo"} +xref: ICD9:296.2 {source="DOID:1470"} +xref: ICD9:296.20 {source="DOID:1470"} +xref: ICD9:296.3 {source="DOID:1470"} +xref: ICD9:296.30 {source="DOID:1470"} +xref: MESH:D003865 {source="EFO:0003761", source="MONDO:equivalentTo", source="DOID:1470"} +xref: MFOMD:0000143 +xref: NCIT:C34796 {source="MONDO:otherHierarchy", source="DOID:1470"} +xref: NCIT:C35094 {source="EFO:0003761", source="MONDO:equivalentTo"} +xref: OMIM:608516 {source="EFO:0003761", source="MONDO:equivalentTo"} +xref: SCTID:300706003 {source="EFO:0003761", source="MONDO:directSiblingOf"} +xref: SCTID:370143000 {source="EFO:0003761", source="MONDO:equivalentTo"} +is_a: MONDO:0002050 {source="DOID:1470", source="MESH:D003865", source="NCIT:C35094"} ! depressive disorder +property_value: exactMatch DOID:1470 +property_value: exactMatch http://identifiers.org/mesh/D003865 +property_value: exactMatch http://identifiers.org/snomedct/370143000 +property_value: exactMatch https://omim.org/entry/608516 +property_value: exactMatch NCIT:C35094 +property_value: relatedMatch NCIT:C34796 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0002021 +name: gingival disorder +def: "A disease involving the gingiva." [MONDO:patterns/location_top] +synonym: "disease of gingiva" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of gingiva" EXACT [] +synonym: "disorder of gingiva" EXACT [MONDO:patterns/location_top] +synonym: "gingiva disease" EXACT [MONDO:patterns/location] +synonym: "gingiva disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1483 {source="MONDO:equivalentTo"} +xref: MESH:D005882 {source="DOID:1483", source="MONDO:equivalentTo"} +xref: SCTID:18718003 {source="DOID:1483", source="MONDO:equivalentTo"} +xref: UMLS:C0017563 {source="DOID:1483", source="MONDO:equivalentTo"} +is_a: MONDO:0002635 {source="DOID:1483", source="MESH:D005882"} ! periodontal disorder +is_a: MONDO:0044992 ! mouth mucosa disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001828 ! gingiva +relationship: disease_has_location UBERON:0001828 ! gingiva +property_value: exactMatch DOID:1483 +property_value: exactMatch http://identifiers.org/mesh/D005882 +property_value: exactMatch http://identifiers.org/snomedct/18718003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017563 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002022 +name: disorder of orbital region +def: "A disease that involves the orbital region." [MONDO:patterns/location] +synonym: "disease of orbital region" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of orbital region" EXACT [] +synonym: "disorder of eye region" EXACT [] +synonym: "disorder of orbital region" EXACT [MONDO:patterns/location_top] +synonym: "eye and adnexa disease" RELATED [DOID:1492] +synonym: "ophthalmological disorder" RELATED [] +synonym: "orbital region disease" EXACT [MONDO:design_pattern] +synonym: "orbital region disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1492 {source="MONDO:equivalentObsolete"} +xref: ICD10CM:H00-H59 {source="MONDO:equivalentTo"} +xref: ICD9:362.10 {source="DOID:1492"} +xref: SCTID:371409005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005042 ! head disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0004088 ! orbital region +relationship: disease_has_location UBERON:0004088 ! orbital region +property_value: exactMatch http://identifiers.org/snomedct/371409005 +property_value: exactMatch https://icd.codes/icd10cm/H00-H59 +property_value: excluded_subClassOf MONDO:0005128 {source="DOID:1492"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002025 +name: psychiatric disorder +def: "A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia." [NCIT:C2893] +synonym: "disease of mental health" NARROW [DOID:150] +synonym: "mental disorder" NARROW [NCIT:C2893] +synonym: "mental dysfunction" NARROW [NCIT:C2893] +synonym: "mental illness" NARROW [NCIT:C2893] +synonym: "Psychiatric disease" EXACT [NCIT:C2893] +synonym: "Psychiatric disorder" EXACT [NCIT:C2893] +xref: DOID:150 {source="MONDO:equivalentTo"} +xref: MESH:D001523 {source="DOID:150", source="MONDO:equivalentTo"} +xref: MFOMD:0000004 +xref: NCIT:C2893 {source="DOID:150", source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts MF:0000020 ! mental process +relationship: disease_disrupts MF:0000020 ! mental process +property_value: exactMatch DOID:150 +property_value: exactMatch http://identifiers.org/mesh/D001523 +property_value: exactMatch NCIT:C2893 +property_value: excluded_subClassOf MONDO:0005071 {source="ISBN-13:978-1-259-64403-0"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0002030 +name: chronic cervicitis +def: "Chronic inflammation of the cervix." [NCIT:P378] +synonym: "cervicitis (disease), chronic" EXACT [MONDO:patterns/chronic] +synonym: "chronic cervicitis (disease)" EXACT [] +xref: DOID:1513 {source="MONDO:equivalentTo"} +xref: NCIT:C27057 {source="MONDO:equivalentTo", source="DOID:1513"} +xref: SCTID:56728002 {source="MONDO:equivalentTo", source="DOID:1513"} +xref: UMLS:C0269062 {source="NCIT:C27057", source="MONDO:equivalentTo", source="DOID:1513"} +is_a: MONDO:0002345 {source="DOID:1513", source="MONDO:Redundant", source="NCIT:C27057"} ! cervicitis +intersection_of: MONDO:0002345 ! cervicitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:1513 +property_value: exactMatch http://identifiers.org/snomedct/56728002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0269062 +property_value: exactMatch NCIT:C27057 + +[Term] +id: MONDO:0002031 +name: cecal disorder +def: "Pathological developments in the cecum." [MESH:D002429] +synonym: "caecum disease" EXACT [MONDO:patterns/location] +synonym: "caecum disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of caecum" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of caecum" EXACT [] +synonym: "disorder of caecum" EXACT [MONDO:patterns/location_top] +xref: DOID:1518 {source="MONDO:equivalentTo"} +xref: MESH:D002429 {source="MONDO:equivalentTo", source="DOID:1518"} +xref: SCTID:128525008 {source="MONDO:equivalentTo", source="DOID:1518"} +xref: UMLS:C0007527 {source="MONDO:equivalentTo", source="DOID:1518"} +is_a: MONDO:0003409 ! colonic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001153 ! caecum +relationship: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:1518 +property_value: exactMatch http://identifiers.org/mesh/D002429 +property_value: exactMatch http://identifiers.org/snomedct/128525008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007527 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002032 +name: colon carcinoma +def: "A carcinoma that arises from epithelial cells of the colon" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of colon" EXACT [DOID:1520, MONDO:patterns/carcinoma, MTH:191, NCIT:C4910] +synonym: "carcinoma of the colon" EXACT [NCIT:C4910] +synonym: "colon cancer" BROAD [NCIT:C4910] +synonym: "colon carcinoma" EXACT [MONDO:patterns/location, NCIT:C4910] +synonym: "colonic carcinoma" EXACT [DOID:1520, NCIT:C4910] +xref: DOID:1520 {source="MONDO:equivalentTo"} +xref: EFO:1001950 {source="MONDO:equivalentTo"} +xref: NCIT:C4910 {source="DOID:1520", source="MONDO:equivalentTo"} +xref: SCTID:269533000 {source="DOID:1520", source="MONDO:equivalentTo"} +xref: UMLS:C0699790 {source="DOID:1520", source="MONDO:equivalentTo", source="NCIT:C4910"} +is_a: MONDO:0021063 {source="DOID:1520", source="MONDO:Redundant", source="NCIT:C4910"} ! malignant colon neoplasm +is_a: MONDO:0024331 ! colorectal carcinoma +is_a: MONDO:0024479 ! epithelial tumor of colon +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:1520 +property_value: exactMatch http://identifiers.org/snomedct/269533000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0699790 +property_value: exactMatch NCIT:C4910 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002033 +name: cecum cancer +def: "A malignant neoplasm involving the caecum" [https://orcid.org/0000-0002-6601-2165] +synonym: "caecum cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of caecum" EXACT [MONDO:patterns/cancer] +synonym: "malignant caecum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant cecum neoplasm" EXACT [NCIT:C9329] +synonym: "malignant cecum tumor" EXACT [NCIT:C9329] +synonym: "malignant neoplasm of caecum" EXACT [DOID:1521, MONDO:patterns/cancer] +synonym: "malignant neoplasm of cecum" EXACT [NCIT:C9329] +synonym: "malignant neoplasm of the cecum" EXACT [NCIT:C9329] +synonym: "malignant tumor of cecum" EXACT [NCIT:C9329] +synonym: "malignant tumor of the cecum" EXACT [DOID:1521, NCIT:C9329] +xref: DOID:1521 {source="MONDO:equivalentTo"} +xref: ICD9:153.4 {source="DOID:1521"} +xref: NCIT:C9329 {source="MONDO:equivalentTo", source="DOID:1521"} +xref: UMLS:C0153437 {source="MONDO:equivalentTo", source="DOID:1521", source="NCIT:C9329"} +is_a: MONDO:0005694 {source="MONDO:Redundant", source="NCIT:C9329"} ! cecal neoplasm +is_a: MONDO:0021063 {source="MONDO:Redundant", source="NCIT:C9329"} ! malignant colon neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:1521 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153437 +property_value: exactMatch NCIT:C9329 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002034 +name: cecum lymphoma +def: "An extranodal lymphoma that arises from the cecum. The majority are B-cell non-Hodgkin lymphomas." [NCIT:C5515] +synonym: "caecum lymphoma" EXACT [MONDO:patterns/location] +synonym: "cecal lymphoma" EXACT [DOID:1522, NCIT:C5515] +synonym: "cecum lymphoma" EXACT [NCIT:C5515] +synonym: "lymphoma of caecum" EXACT [MONDO:design_pattern] +synonym: "lymphoma of cecum" EXACT [NCIT:C5515] +synonym: "lymphoma of the cecum" EXACT [NCIT:C5515] +synonym: "primary cecum lymphoma" EXACT [NCIT:C5515] +xref: DOID:1522 {source="MONDO:equivalentTo"} +xref: NCIT:C5515 {source="DOID:1522", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332867 {source="DOID:1522", source="MONDO:equivalentTo", source="NCIT:C5515"} +is_a: MONDO:0002033 {source="DOID:1522", source="MONDO:Redundant", source="NCIT:C5515"} ! cecum cancer +is_a: MONDO:0002035 {source="MONDO:Redundant", source="NCIT:C5515"} ! colon lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:1522 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332867 +property_value: exactMatch NCIT:C5515 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0002035 +name: colon lymphoma +def: "An extranodal lymphoma that arises from the colon. The majority are B-cell non-Hodgkin lymphomas." [NCIT:C4793] +synonym: "colon lymphoma" EXACT [MONDO:patterns/location, NCIT:C4793] +synonym: "colonic lymphoma" EXACT [DOID:1523, NCIT:C4793] +synonym: "lymphoma of colon" EXACT [NCIT:C4793] +synonym: "lymphoma of the colon" EXACT [NCIT:C4793] +synonym: "primary colon lymphoma" EXACT [NCIT:C4793] +xref: DOID:1523 {source="MONDO:equivalentTo"} +xref: ICD9:202.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4793 {source="MONDO:equivalentTo", source="DOID:1523", source="MONDO:exact-label-match"} +xref: SCTID:133751000119102 {source="MONDO:equivalentTo", source="DOID:1523"} +xref: UMLS:C0519037 {source="NCIT:C4793", source="MONDO:equivalentTo", source="DOID:1523"} +is_a: MONDO:0021063 {source="DOID:1523", source="MONDO:Redundant", source="NCIT:C4793"} ! malignant colon neoplasm +is_a: MONDO:0024656 ! colorectal lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:1523 +property_value: exactMatch http://identifiers.org/snomedct/133751000119102 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0519037 +property_value: exactMatch NCIT:C4793 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0002036 +name: penile disorder +def: "A non-neoplastic or neoplastic disorder that affects the penis. Representative examples of non-neoplastic disorders include phimosis, balanitis, and hypospadias. Representative examples of neoplastic disorders include hemangioma, penile intraepithelial neoplasia, and penile carcinoma." [NCIT:P378] +synonym: "disease of penis" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of penis" EXACT [] +synonym: "disorder of penis" EXACT [MONDO:patterns/location_top] +synonym: "penile disease" EXACT [NCIT:C26846] +synonym: "penile disorder" EXACT [NCIT:C26846] +synonym: "penis disease" EXACT [MONDO:patterns/location] +synonym: "penis disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1529 {source="MONDO:equivalentTo"} +xref: ICD9:607.8 {source="DOID:1529"} +xref: ICD9:607.89 {source="DOID:1529"} +xref: ICD9:607.9 +xref: MESH:D010409 {source="MONDO:equivalentTo"} +xref: NCIT:C26846 {source="MONDO:equivalentTo"} +xref: SCTID:33958003 {source="MONDO:equivalentTo"} +xref: UMLS:C0030846 {source="MONDO:equivalentTo", source="NCIT:C26846"} +is_a: MONDO:0003150 {source="DOID:1529", source="MESH:D010409", source="MONDO:Redundant", source="NCIT:C26846"} ! male reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000989 ! penis +relationship: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch DOID:1529 +property_value: exactMatch http://identifiers.org/mesh/D010409 +property_value: exactMatch http://identifiers.org/snomedct/33958003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030846 +property_value: exactMatch NCIT:C26846 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002037 +name: pleural disorder +def: "A non-neoplastic or neoplastic disorder that affects the pleura. Representative examples include pleural infection, pleural mesothelioma, and pleural solitary fibrous tumor." [NCIT:P378] +synonym: "disease of pleura" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pleura" EXACT [] +synonym: "disorder of pleura" EXACT [DOID:1532, MONDO:patterns/location_top] +synonym: "non-neoplastic pleural disease" EXACT [DOID:1532] +synonym: "pleura disease" EXACT [MONDO:patterns/location] +synonym: "pleura disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "pleural disorder" EXACT [NCIT:C26859] +synonym: "pleural disorders" EXACT [NCIT:C26859] +xref: DOID:1532 {source="MONDO:equivalentTo"} +xref: ICD9:518.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010995 {source="MONDO:equivalentTo", source="DOID:1532"} +xref: NCIT:C26859 {source="MONDO:equivalentTo", source="DOID:1532"} +xref: SCTID:88075009 {source="MONDO:equivalentTo", source="DOID:1532"} +xref: UMLS:C0032226 {source="MONDO:equivalentTo", source="DOID:1532"} +is_a: MONDO:0000270 {source="DOID:1532", source="MONDO:Redundant"} ! lower respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000977 ! pleura +relationship: disease_has_location UBERON:0000977 ! pleura +property_value: exactMatch DOID:1532 +property_value: exactMatch http://identifiers.org/mesh/D010995 +property_value: exactMatch http://identifiers.org/snomedct/88075009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0032226 +property_value: exactMatch NCIT:C26859 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002038 +name: head and neck carcinoma +def: "A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." [NCIT:C35850] +synonym: "carcinoma of craniocervical region" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of head and neck" EXACT [NCIT:C35850] +synonym: "carcinoma of neck" EXACT [DOID:1542, MONDO:patterns/carcinoma] +synonym: "carcinoma of the head and neck" EXACT [NCIT:C35850] +synonym: "carcinoma of the neck" EXACT [DOID:1542, NCIT:C6077] +synonym: "craniocervical region carcinoma" EXACT [MONDO:patterns/location] +synonym: "head and neck cancer" RELATED [NCIT:C35850] +synonym: "head and neck carcinoma" EXACT [NCIT:C35850] +synonym: "neck carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:1542 {source="MONDO:equivalentTo"} +xref: NCIT:C35850 {source="MONDO:equivalentTo"} +xref: UMLS:C1334927 {source="DOID:1542", source="MONDO:equivalentTo"} +xref: UMLS:C3887461 {source="MONDO:equivalentTo", source="NCIT:C35850"} +is_a: MONDO:0004993 {source="MONDO:Redundant", source="NCIT:C35850"} ! carcinoma +is_a: MONDO:0005627 {source="DOID:1542", source="MONDO:Redundant", source="NCIT:C35850"} ! head and neck cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0007811 ! craniocervical region +property_value: exactMatch DOID:1542 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334927 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3887461 +property_value: exactMatch NCIT:C35850 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002039 +name: cognitive disorder +def: "A disease affects cognitive processes." [https://orcid.org/0000-0002-6601-2165] +synonym: "cognitive disease" EXACT [DOID:1561] +synonym: "cognitive disorder" EXACT [NCIT:C92196] +synonym: "organic mental disorder" RELATED [DOID:1561, NCIT:C34870] +xref: DOID:1561 {source="MONDO:equivalentTo"} +xref: EFO:1001457 {source="MONDO:equivalentTo"} +xref: ICD9:294.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D019965 {source="DOID:1561", source="MONDO:equivalentTo"} +xref: NCIT:C92196 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:443265004 {source="MONDO:equivalentTo"} +is_a: MONDO:0002025 {source="MESH:D019965", source="MONDO:Redundant", source="NCIT:C92196"} ! psychiatric disorder +intersection_of: MONDO:0002025 ! psychiatric disorder +intersection_of: disease_disrupts MF:0000008 ! cognitive process +relationship: disease_disrupts MF:0000008 ! cognitive process +property_value: exactMatch DOID:1561 +property_value: exactMatch http://identifiers.org/mesh/D019965 +property_value: exactMatch http://identifiers.org/snomedct/443265004 +property_value: exactMatch NCIT:C92196 + +[Term] +id: MONDO:0002050 +name: depressive disorder +def: "A melancholy feeling of sadness and despair." [NCIT:C2982] +synonym: "depression" EXACT [NCIT:C2982] +synonym: "melancholia" RELATED [MESH:D003866] +synonym: "melancholias" RELATED [MESH:D003866] +synonym: "mental depression" EXACT [DOID:1596] +synonym: "syndrome, depressive" RELATED [MESH:D003866] +synonym: "syndromes, depressive" RELATED [MESH:D003866] +xref: DOID:1596 {source="MONDO:equivalentTo"} +xref: ICD10CM:F32 {source="MONDO:equivalentTo"} +xref: ICD9:311 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003866 {source="MONDO:equivalentTo"} +xref: MFOMD:0000013 +xref: NCIT:C2982 {source="DOID:1596", source="MONDO:equivalentTo"} +xref: SCTID:35489007 {source="MONDO:equivalentTo"} +xref: UMLS:CN236658 {source="MONDO:equivalentTo"} +is_a: MONDO:0005371 {source="DOID:1596", source="ICD10CM:F32", source="MESH:D003866", source="NCIT:C2982"} ! mood disorder +property_value: exactMatch DOID:1596 +property_value: exactMatch http://identifiers.org/mesh/D003866 +property_value: exactMatch http://identifiers.org/snomedct/35489007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236658 +property_value: exactMatch https://icd.codes/icd10cm/F32 +property_value: exactMatch NCIT:C2982 + +[Term] +id: MONDO:0002051 +name: integumentary system disorder +alt_id: MONDO:0045027 +def: "A disease involving the integumental system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of integumental system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of integumental system" EXACT [] +synonym: "disorder of integument" RELATED [] +synonym: "disorder of integumental system" EXACT [MONDO:patterns/location_top] +synonym: "integumental system disease" EXACT [MONDO:patterns/location] +synonym: "integumental system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "integumentary disease" EXACT [DOID:16] +xref: DOID:16 {source="MONDO:equivalentTo"} +xref: SCTID:128598002 {source="MONDO:equivalentTo"} +xref: UMLS:C1290011 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002416 ! integumental system +relationship: disease_has_location UBERON:0002416 ! integumental system +property_value: exactMatch DOID:16 +property_value: exactMatch http://identifiers.org/snomedct/128598002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290011 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002052 +name: lymphadenitis +def: "Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process." [NCIT:C26821] +synonym: "acute adenitis" EXACT [DOID:1602] +synonym: "acute lymphadenitis" EXACT [DOID:1602, ICD9CM:683] +synonym: "adenitis" EXACT [DOID:1602, NCIT:C26821] +synonym: "chronic adenitis" EXACT [DOID:1602] +synonym: "chronic lymphadenitis" EXACT [DOID:1602, NCIT:C26966] +synonym: "Inflammation of lymph node" EXACT [DOID:1602] +synonym: "inflammation of lymph node" EXACT [] +synonym: "lymph gland infection" RELATED [NCIT:C26821] +synonym: "lymph node inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "lymph nodeitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "lymphadenitis" EXACT [MONDO:ambiguous] +synonym: "lymphadenitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1602 {source="MONDO:equivalentTo"} +xref: HP:0002840 {source="MONDO:otherHierarchy"} +xref: ICD9:289.1 {source="DOID:1602"} +xref: ICD9:683 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1602"} +xref: MESH:D008199 {source="MONDO:equivalentTo", source="DOID:1602"} +xref: NCIT:C26821 {source="MONDO:equivalentTo", source="DOID:1602"} +xref: SCTID:41174002 {source="MONDO:equivalentTo", source="DOID:1602"} +xref: UMLS:C0024205 {source="MONDO:equivalentTo", source="NCIT:C26821", source="DOID:1602"} +xref: UMLS:C0154304 {source="MONDO:equivalentTo", source="DOID:1602"} +xref: UMLS:C0157705 {source="MONDO:equivalentTo", source="DOID:1602"} +is_a: MONDO:0004928 {source="DOID:1602", source="MONDO:Redundant", source="NCIT:C26821"} ! lymph node disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000029 ! lymph node +relationship: disease_arises_from_structure CL:0000542 ! lymphocyte +relationship: disease_has_inflammation_site UBERON:0000029 ! lymph node +property_value: exactMatch DOID:1602 +property_value: exactMatch http://identifiers.org/mesh/D008199 +property_value: exactMatch http://identifiers.org/snomedct/41174002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024205 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154304 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0157705 +property_value: exactMatch NCIT:C26821 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "lymphadenitis (disease)" xsd:string + +[Term] +id: MONDO:0002060 +name: intraductal papilloma +def: "An intraluminal papillary epithelial neoplasm arising within the ducts. Representative examples are the intraductal breast papilloma and the salivary gland intraductal papilloma." [NCIT:C3785] +synonym: "duct adenoma" EXACT [NCIT:C3785] +synonym: "duct papilloma" EXACT [MONDO:patterns/location] +synonym: "ductal papilloma" EXACT [DOID:1627, NCIT:C3785] +synonym: "intraductal papilloma" EXACT [NCIT:C3785] +synonym: "intraductal papilloma (morphologic abnormality)" EXACT [DOID:1627] +xref: DOID:1627 {source="MONDO:equivalentTo"} +xref: ICDO:8503/0 {source="NCIT:C3785"} +xref: MESH:D018300 {source="MONDO:equivalentTo", source="DOID:1627"} +xref: NCIT:C3785 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:1627"} +xref: UMLS:C0206713 {source="MONDO:equivalentTo", source="NCIT:C3785", source="DOID:1627"} +is_a: MONDO:0002363 {source="DOID:1627", source="MONDO:Redundant", source="NCIT:C3785"} ! papilloma +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0000058 ! duct +relationship: disease_has_location UBERON:0000058 ! duct +property_value: exactMatch DOID:1627 +property_value: exactMatch http://identifiers.org/mesh/D018300 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206713 +property_value: exactMatch NCIT:C3785 + +[Term] +id: MONDO:0002061 +name: intraductal papillary breast neoplasm +def: "A benign or malignant papillary neoplasm that arises anywhere in the ductal system of the breast. It is characterized by fibrovascular structures lined by epithelial proliferations. This category includes intraductal papilloma and intraductal papillary carcinoma." [NCIT:C36090] +synonym: "intraductal papillary breast neoplasm" EXACT [NCIT:C36090] +xref: DOID:1628 {source="MONDO:equivalentTo"} +xref: NCIT:C36090 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:1628"} +xref: UMLS:C1334252 {source="MONDO:equivalentTo", source="NCIT:C36090", source="DOID:1628"} +is_a: MONDO:0002488 {source="DOID:1628", source="NCIT:C36090"} ! intraductal breast neoplasm +property_value: exactMatch DOID:1628 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334252 +property_value: exactMatch NCIT:C36090 + +[Term] +id: MONDO:0002071 +name: supratentorial cancer +def: "Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and brain STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation." [MESH:D015173] +synonym: "brain neoplasm, supratentorial" EXACT [DOID:1659, NCIT:C3397] +synonym: "malignant supratentorial neoplasm" EXACT [NCIT:C4964] +synonym: "malignant supratentorial tumor" EXACT [DOID:1659, NCIT:C4964] +synonym: "supratentorial neoplasms, malignant" EXACT [NCIT:C4964] +xref: DOID:1659 {source="MONDO:equivalentTo"} +xref: MESH:D015173 {source="MONDO:equivalentTo", source="DOID:1659"} +xref: NCIT:C4964 {source="MONDO:equivalentTo", source="DOID:1659"} +is_a: MONDO:0001657 {source="DOID:1659", source="MESH:D015173", source="NCIT:C4964"} ! brain cancer +relationship: disease_has_location UBERON:0001893 ! telencephalon +property_value: exactMatch DOID:1659 +property_value: exactMatch http://identifiers.org/mesh/D015173 +property_value: exactMatch NCIT:C4964 + +[Term] +id: MONDO:0002073 +name: malignant pineal area germ cell neoplasm +def: "A malignant germ cell tumor that arises in the pineal region. Representative examples include germinoma, immature teratoma, choriocarcinoma, embryonal carcinoma and yolk sac tumor." [NCIT:P378] +subset: gard_rare +synonym: "malignant germ cell neoplasm of pineal gland" EXACT [NCIT:C6767] +synonym: "malignant germ cell neoplasm of pineal parenchyma" EXACT [NCIT:C6767] +synonym: "malignant germ cell neoplasm of the pineal gland" EXACT [NCIT:C6767] +synonym: "malignant germ cell neoplasm of the pineal parenchyma" EXACT [NCIT:C6767] +synonym: "malignant germ cell tumor of pineal gland" EXACT [NCIT:C6767] +synonym: "malignant germ cell tumor of pineal parenchyma" EXACT [NCIT:C6767] +synonym: "malignant germ cell tumor of the pineal gland" EXACT [NCIT:C6767] +synonym: "malignant germ cell tumor of the pineal parenchyma" EXACT [NCIT:C6767] +synonym: "malignant pineal area germ cell tumor" EXACT [NCIT:C6767] +synonym: "malignant pineal gland germ cell neoplasm" EXACT [NCIT:C6767] +synonym: "malignant pineal gland germ cell tumor" EXACT [NCIT:C6767] +synonym: "malignant pineal parenchymal germ cell neoplasm" EXACT [NCIT:C6767] +synonym: "malignant pineal parenchymal germ cell tumor" EXACT [DOID:1660, NCIT:C6767] +synonym: "malignant pineal region germ cell neoplasm" EXACT [NCIT:C6767] +synonym: "malignant pineal region germ cell tumor" EXACT [NCIT:C6767] +synonym: "pineal cell tumor" RELATED [GARD:0012017] +synonym: "pineal cell tumour" RELATED [GARD:0012017] +synonym: "pineal germ cell neoplasm, malignant" EXACT [NCIT:C6767] +synonym: "pineal germ cell tumor" EXACT [DOID:1660] +synonym: "pineal region germ cell tumor" EXACT [DOID:1660, NCIT:C4659] +synonym: "pineal region germinoma" RELATED [GARD:0012017] +xref: DOID:1660 {source="MONDO:equivalentTo"} +xref: GARD:0012017 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6767 {source="DOID:1660", source="MONDO:equivalentTo"} +xref: SCTID:277508009 {source="DOID:1660", source="MONDO:equivalentTo"} +xref: UMLS:C0349621 {source="DOID:1660", source="MONDO:equivalentTo"} +xref: UMLS:C1334612 {source="DOID:1660", source="MONDO:equivalentTo", source="NCIT:C6767"} +is_a: MONDO:0003000 ! central nervous system germ cell tumor +is_a: MONDO:0003113 ! extragonadal germ cell cancer +is_a: MONDO:0003249 {source="DOID:1660", source="MONDO:Redundant", source="NCIT:C6767"} ! pineal gland cancer +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0001905 ! pineal body +property_value: exactMatch DOID:1660 +property_value: exactMatch http://identifiers.org/snomedct/277508009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349621 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334612 +property_value: exactMatch NCIT:C6767 + +[Term] +id: MONDO:0002081 +name: musculoskeletal system disorder +def: "A disease involving the musculoskeletal system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of musculoskeletal system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of musculoskeletal system" EXACT [] +synonym: "disorder of musculoskeletal system" EXACT [MONDO:patterns/location_top] +synonym: "musculoskeletal disease" EXACT [DOID:17] +synonym: "musculoskeletal disorder" RELATED [] +synonym: "musculoskeletal system disease" EXACT [MONDO:patterns/location] +synonym: "musculoskeletal system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "musculoskeletal system disorder" EXACT [NCIT:C107377] +xref: DOID:17 {source="MONDO:equivalentTo"} +xref: ICD9:729.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009140 {source="MONDO:equivalentTo", source="DOID:17"} +xref: NCIT:C107377 {source="MONDO:equivalentTo", source="DOID:17"} +xref: SCTID:928000 {source="MONDO:equivalentTo", source="DOID:17"} +xref: UMLS:C0026857 {source="MONDO:equivalentTo", source="DOID:17"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002204 ! musculoskeletal system +relationship: disease_has_location UBERON:0002204 ! musculoskeletal system +property_value: exactMatch DOID:17 +property_value: exactMatch http://identifiers.org/mesh/D009140 +property_value: exactMatch http://identifiers.org/snomedct/928000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026857 +property_value: exactMatch NCIT:C107377 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002082 +name: endocrine gland neoplasm +def: "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma." [NCIT:C3010] +synonym: "endocrine gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "endocrine gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "endocrine neoplasm" EXACT [DOID:170, NCIT:C3010] +synonym: "endocrine system neoplasm" EXACT [NCIT:C3010] +synonym: "endocrine system tumor" EXACT [NCIT:C3010] +synonym: "endocrine tumor" EXACT [DOID:170, NCIT:C3010] +synonym: "malignant endocrine tumor" NARROW [DOID:170] +synonym: "neoplasm of endocrine gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of endocrine gland" EXACT [MONDO:patterns/neoplasm] +xref: EFO:0003769 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3010 {source="MONDO:equivalentTo"} +xref: SCTID:387922007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C3010/inferred"} ! neoplasm +is_a: MONDO:0005151 {source="MONDO:Redundant", source="NCIT:C3010"} ! endocrine system disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002368 ! endocrine gland +relationship: disease_has_location UBERON:0002368 ! endocrine gland +property_value: exactMatch http://identifiers.org/snomedct/387922007 +property_value: exactMatch NCIT:C3010 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002087 +name: peritoneum cancer +def: "A malignant neoplasm involving the peritoneum" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of peritoneum" EXACT [DOID:1725, MONDO:patterns/cancer] +synonym: "cancer of the peritoneum" EXACT [NCIT:C3538] +synonym: "malignant neoplasm of peritoneum" EXACT [MONDO:patterns/cancer] +synonym: "malignant peritoneal neoplasm" EXACT [NCIT:C3538] +synonym: "malignant peritoneum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "peritoneal cancer" EXACT [NCIT:C3538] +synonym: "peritoneal cavity cancer" EXACT [NCIT:C3538] +synonym: "peritoneal neoplasm" RELATED [DOID:1725] +synonym: "peritoneum cancer" EXACT [MONDO:patterns/location] +xref: DOID:1725 {source="MONDO:equivalentTo"} +xref: ICD9:158.8 {source="DOID:1725"} +xref: ICD9:158.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:159.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3538 {source="MONDO:equivalentTo"} +xref: SCTID:363492001 {source="MONDO:equivalentTo"} +xref: UMLS:C0153467 {source="MONDO:equivalentTo", source="NCIT:C3538"} +is_a: MONDO:0004992 {source="DOID:1725", source="DOID:1725/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0006901 {source="MONDO:Redundant", source="NCIT:C3538"} ! peritoneal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002358 ! peritoneum +property_value: exactMatch DOID:1725 +property_value: exactMatch http://identifiers.org/snomedct/363492001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153467 +property_value: exactMatch NCIT:C3538 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002090 +name: eccrine sweat gland neoplasm +def: "A neoplasm involving a eccrine sweat gland." [MONDO:patterns/neoplasm] +synonym: "eccrine neoplasm" EXACT [NCIT:C6796] +synonym: "eccrine neoplasm of skin" EXACT [NCIT:C6796] +synonym: "eccrine neoplasm of the skin" EXACT [NCIT:C6796] +synonym: "eccrine skin neoplasm" EXACT [DOID:173, NCIT:C6796] +synonym: "eccrine skin tumor" EXACT [NCIT:C6796] +synonym: "eccrine sweat gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "eccrine sweat gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "eccrine tumor" EXACT [DOID:173, NCIT:C6796] +synonym: "eccrine tumor of skin" EXACT [NCIT:C6796] +synonym: "eccrine tumor of the skin" EXACT [NCIT:C6796] +synonym: "neoplasm of eccrine sweat gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of eccrine sweat gland" EXACT [MONDO:patterns/neoplasm] +xref: DOID:173 {source="MONDO:equivalentTo"} +xref: NCIT:C6796 {source="MONDO:equivalentTo", source="DOID:173"} +xref: UMLS:C1333371 {source="MONDO:equivalentTo", source="NCIT:C6796", source="DOID:173"} +is_a: MONDO:0002381 {source="DOID:173", source="MONDO:Redundant", source="NCIT:C6796"} ! sweat gland neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000423 ! eccrine sweat gland +relationship: disease_has_location UBERON:0000423 ! eccrine sweat gland +property_value: exactMatch DOID:173 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333371 +property_value: exactMatch NCIT:C6796 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002095 +name: vascular cancer +def: "A malignant neoplasm arising from the blood vessels." [NCIT:C8538] +comment: Editor note: see also NCIT:C7390 +synonym: "blood vessel neoplasm" BROAD [DOID:175, NCIT:C7387] +synonym: "blood vessel tumor" BROAD [DOID:175] +synonym: "blood vessel tumor (morphologic abnormality)" BROAD [DOID:175] +synonym: "blood vessel tumors" BROAD [DOID:175] +synonym: "blood vessel tumors (morphologic abnormality)" BROAD [DOID:175] +synonym: "blood vessel tumour disorder" BROAD [DOID:175] +synonym: "cancer of vasculature" EXACT [MONDO:patterns/cancer] +synonym: "Haemangiomatous tumour" BROAD [DOID:175] +synonym: "leiomyosarcoma of the renal vein" NARROW [DOID:175, NCIT:C5388] +synonym: "malignant blood vessel neoplasm" EXACT [NCIT:C8538] +synonym: "malignant blood vessel tumor" EXACT [NCIT:C8538] +synonym: "malignant neoplasm of vasculature" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of pulmonary artery" NARROW [DOID:175, NCIT:C5380] +synonym: "malignant tumor of pulmonary vein" NARROW [DOID:175, NCIT:C5383] +synonym: "malignant vascular neoplasm" EXACT [DOID:175] +synonym: "malignant vascular tumor" EXACT [DOID:175, NCIT:C7390] +synonym: "malignant vasculature neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of great vessel" BROAD [DOID:175] +synonym: "pulmonary artery cancer" EXACT [MONDO:patterns/location] +synonym: "pulmonary artery malignant neoplasm" EXACT [DOID:175] +synonym: "pulmonary vein malignant neoplasm" EXACT [DOID:175] +synonym: "renal vein leiomyosarcoma" RELATED [DOID:175] +synonym: "vascular tissue neoplasm" RELATED [DOID:175] +synonym: "vascular tumors" BROAD [DOID:175, NCIT:C7388] +synonym: "vasculature cancer" EXACT [] +xref: DOID:175 {source="MONDO:equivalentTo"} +xref: MESH:D009383 {source="MONDO:equivalentTo"} +xref: NCIT:C8538 {source="MONDO:equivalentTo"} +is_a: MONDO:0002100 {source="DOID:175", source="MONDO:Redundant", source="NCIT:C8538/inferred"} ! cardiovascular cancer +is_a: MONDO:0021080 {source="MONDO:Entailed", source="NCIT:C8538"} ! blood vessel neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002049 ! vasculature +property_value: exactMatch DOID:175 +property_value: exactMatch http://identifiers.org/mesh/D009383 +property_value: exactMatch NCIT:C8538 +property_value: excluded_subClassOf MONDO:0000473 {source="DOID:175"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002098 +name: facial nerve disorder +def: "A disease involving the facial nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of facial nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of facial nerve" EXACT [] +synonym: "disorder of facial nerve" EXACT [MONDO:patterns/location_top] +synonym: "disorder of seventh cranial nerve" RELATED [] +synonym: "disorders of the seventh nerve" RELATED [] +synonym: "disorders of the VIIth cranial nerve" RELATED [] +synonym: "facial nerve disease" EXACT [MONDO:patterns/location] +synonym: "facial nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "facial nerve disorder" EXACT [] +synonym: "facial neuropathy" RELATED [] +xref: DOID:1756 {source="MONDO:equivalentTo"} +xref: ICD10CM:G51 {source="MONDO:equivalentTo", source="DOID:1756"} +xref: ICD9:351 {source="DOID:1756"} +xref: ICD9:351.9 {source="DOID:1756"} +xref: MESH:D005155 {source="MONDO:equivalentTo", source="DOID:1756"} +xref: NCIT:C27594 {source="MONDO:equivalentTo", source="DOID:1756"} +xref: SCTID:422426003 {source="MONDO:equivalentTo", source="DOID:1756"} +xref: UMLS:C0015464 {source="MONDO:equivalentTo", source="DOID:1756"} +is_a: MONDO:0003569 {source="DOID:1756", source="MESH:D005155", source="MONDO:Redundant", source="NCIT:C27594"} ! cranial nerve neuropathy +is_a: MONDO:0003620 {source="DOID:1756/inferred", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001647 ! facial nerve +relationship: disease_has_location UBERON:0001647 ! facial nerve +property_value: exactMatch DOID:1756 +property_value: exactMatch http://identifiers.org/mesh/D005155 +property_value: exactMatch http://identifiers.org/snomedct/422426003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015464 +property_value: exactMatch https://icd.codes/icd10cm/G51 +property_value: exactMatch NCIT:C27594 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002100 +name: cardiovascular cancer +def: "A primary or metastatic malignant neoplasm involving the cardiovascular system." [NCIT:C114940] +synonym: "cancer of cardiovascular system" EXACT [MONDO:patterns/cancer] +synonym: "cardiovascular neoplasm" BROAD [DOID:176] +synonym: "cardiovascular system cancer" EXACT [] +synonym: "cardiovascular tumors" EXACT [DOID:176] +synonym: "malignant cardiovascular neoplasm" EXACT [NCIT:C114940] +synonym: "malignant cardiovascular system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of cardiovascular system" EXACT [MONDO:patterns/cancer] +xref: DOID:176 {source="MONDO:equivalentTo"} +xref: NCIT:C114940 {source="MONDO:equivalentTo"} +xref: UMLS:C0497243 {source="MONDO:equivalentTo", source="DOID:176"} +xref: UMLS:C3898472 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:176", source="DOID:176/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0024757 {source="MONDO:Redundant", source="NCIT:C114940"} ! cardiovascular neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004535 ! cardiovascular system +property_value: exactMatch DOID:176 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0497243 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3898472 +property_value: exactMatch NCIT:C114940 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002101 +name: facial nerve neoplasm +def: "A neoplasm involving a facial nerve." [MONDO:patterns/neoplasm] +synonym: "facial nerve neoplasm" EXACT [NCIT:C5827] +synonym: "facial nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "facial nerve neoplasms" EXACT [NCIT:C5827] +synonym: "facial nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5827] +synonym: "facial nerve tumors" EXACT [NCIT:C5827] +synonym: "neoplasm of Facial nerve" EXACT [NCIT:C5827] +synonym: "neoplasm of facial nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of seventh cranial nerve" EXACT [NCIT:C5827] +synonym: "neoplasm of the Facial nerve" EXACT [NCIT:C5827] +synonym: "neoplasm of the seventh cranial nerve" EXACT [NCIT:C5827] +synonym: "seventh cranial nerve neoplasm" EXACT [NCIT:C5827] +synonym: "seventh cranial nerve neoplasms" EXACT [NCIT:C5827] +synonym: "seventh cranial nerve tumor" EXACT [NCIT:C5827] +synonym: "seventh cranial nerve tumors" EXACT [NCIT:C5827] +synonym: "tumor of Facial nerve" EXACT [DOID:1760, NCIT:C5827] +synonym: "tumor of facial nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of seventh cranial nerve" EXACT [NCIT:C5827] +synonym: "tumor of the Facial nerve" EXACT [NCIT:C5827] +synonym: "tumor of the seventh cranial nerve" EXACT [NCIT:C5827] +synonym: "VIIth cranial nerve neoplasms" EXACT [NCIT:C5827] +synonym: "VIIth cranial nerve tumors" EXACT [NCIT:C5827] +xref: DOID:1760 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5827 {source="DOID:1760", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126973004 {source="DOID:1760", source="MONDO:equivalentTo"} +xref: UMLS:C1263899 {source="NCIT:C5827", source="DOID:1760", source="MONDO:equivalentTo"} +is_a: MONDO:0002098 ! facial nerve disorder +is_a: MONDO:0002633 {source="DOID:1760", source="MONDO:Redundant", source="NCIT:C5827"} ! cranial nerve neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001647 ! facial nerve +property_value: exactMatch DOID:1760 +property_value: exactMatch http://identifiers.org/snomedct/126973004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263899 +property_value: exactMatch NCIT:C5827 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002102 +name: cheilitis +def: "An inflammatory process affecting the lip." [NCIT:C79545] +synonym: "inflammation of lip" EXACT [] +synonym: "lip inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:1762 {source="MONDO:equivalentTo"} +xref: HP:0100825 {source="DOID:1762", source="MONDO:otherHierarchy"} +xref: MESH:D002613 {source="DOID:1762", source="MONDO:equivalentTo"} +xref: NCIT:C79545 {source="DOID:1762", source="MONDO:equivalentTo"} +xref: SCTID:7847004 {source="DOID:1762", source="MONDO:equivalentTo"} +xref: UMLS:C0007971 {source="DOID:1762", source="MONDO:equivalentTo", source="NCIT:C79545"} +is_a: MONDO:0004748 {source="DOID:1762", source="MESH:D002613", source="MONDO:Redundant", source="NCIT:C79545/inferred"} ! lip disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001833 ! lip +relationship: disease_has_inflammation_site UBERON:0001833 ! lip +property_value: exactMatch DOID:1762 +property_value: exactMatch http://identifiers.org/mesh/D002613 +property_value: exactMatch http://identifiers.org/snomedct/7847004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007971 +property_value: exactMatch NCIT:C79545 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002108 +name: thyroid cancer +def: "A malignant neoplasm involving the thyroid gland" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of thyroid gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the thyroid" EXACT [NCIT:C7510] +synonym: "malignant neoplasm of the thyroid gland" EXACT [NCIT:C7510] +synonym: "malignant neoplasm of thyroid" EXACT [NCIT:C7510] +synonym: "malignant neoplasm of thyroid gland" EXACT [DOID:1781, ICD9CM:193, MONDO:patterns/cancer, NCIT:C7510] +synonym: "malignant thyroid gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7510] +synonym: "malignant thyroid gland tumor" EXACT [NCIT:C7510] +synonym: "malignant thyroid neoplasm" EXACT [NCIT:C7510] +synonym: "malignant thyroid tumor" EXACT [NCIT:C7510] +synonym: "malignant tumor of the thyroid" EXACT [NCIT:C7510] +synonym: "malignant tumor of the thyroid gland" EXACT [NCIT:C7510] +synonym: "malignant tumor of thyroid" EXACT [NCIT:C7510] +synonym: "malignant tumor of thyroid gland" EXACT [NCIT:C7510] +synonym: "malignant tumour of thyroid gland" EXACT [DOID:1781] +synonym: "neoplasm of thyroid gland" BROAD [DOID:1781] +synonym: "thyroid gland cancer" EXACT [MONDO:patterns/location] +synonym: "thyroid gland neoplasm" BROAD [DOID:1781] +xref: DOID:1781 {source="MONDO:equivalentTo"} +xref: ICD9:193 {source="DOID:1781", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: KEGG:05216 {source="DOID:1781", source="MONDO:relatedTo"} +xref: NCIT:C7510 {source="DOID:1781", source="MONDO:equivalentTo"} +xref: SCTID:363478007 {source="DOID:1781", source="MONDO:equivalentTo"} +xref: UMLS:CN221577 {source="MONDO:equivalentTo"} +is_a: MONDO:0015074 {source="MONDO:Redundant", source="NCIT:C7510"} ! thyroid tumor +is_a: MONDO:0021069 ! malignant endocrine neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch DOID:1781 +property_value: exactMatch http://identifiers.org/snomedct/363478007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN221577 +property_value: exactMatch NCIT:C7510 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002109 +name: pituitary cancer +def: "A primary or metastatic malignant neoplasm affecting the pituitary gland. Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract." [NCIT:C4769] +synonym: "cancer of pituitary gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pituitary" EXACT [NCIT:C4769] +synonym: "malignant neoplasm of pituitary gland" EXACT [MONDO:patterns/cancer, NCIT:C4769] +synonym: "malignant neoplasm of the pituitary" EXACT [NCIT:C4769] +synonym: "malignant neoplasm of the pituitary gland" EXACT [NCIT:C4769] +synonym: "malignant pituitary gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4769] +synonym: "malignant pituitary gland tumor" EXACT [NCIT:C4769] +synonym: "malignant pituitary neoplasm" EXACT [DOID:1785, NCIT:C4769] +synonym: "malignant pituitary tumor" EXACT [NCIT:C4769] +synonym: "malignant tumor of pituitary" EXACT [NCIT:C4769] +synonym: "malignant tumor of pituitary gland" EXACT [NCIT:C4769] +synonym: "malignant tumor of the pituitary" EXACT [NCIT:C4769] +synonym: "malignant tumor of the pituitary gland" EXACT [NCIT:C4769] +synonym: "pituitary cancer" EXACT [] +synonym: "pituitary gland cancer" EXACT [DOID:1785] +synonym: "pituitary gland neoplasm" BROAD [DOID:1785, NCIT:C3330] +synonym: "pituitary neoplasm" BROAD [DOID:1785] +synonym: "pituitary neoplasms, malignant" EXACT [NCIT:C4769] +synonym: "pituitary tumor, malignant" EXACT [NCIT:C4769] +xref: DOID:1785 {source="MONDO:equivalentTo"} +xref: EFO:0005578 {source="MONDO:equivalentTo"} +xref: GARD:0009371 {source="MONDO:equivalentTo"} +xref: NCIT:C4769 {source="MONDO:equivalentTo", source="DOID:1785"} +xref: SCTID:363482009 {source="MONDO:equivalentTo", source="DOID:1785"} +xref: UMLS:C0496842 {source="MONDO:equivalentTo", source="DOID:1785", source="NCIT:C4769"} +is_a: MONDO:0002132 ! skull cancer +is_a: MONDO:0003766 ! thalamic cancer +is_a: MONDO:0017611 {source="MONDO:Redundant", source="NCIT:C4769"} ! pituitary tumor +is_a: MONDO:0021069 ! malignant endocrine neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +property_value: exactMatch DOID:1785 +property_value: exactMatch http://identifiers.org/snomedct/363482009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496842 +property_value: exactMatch NCIT:C4769 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002113 +name: peritoneal carcinoma +def: "A rare carcinoma that arises from the peritoneum and resembles the malignant surface epithelial-stromal tumors that arise from the ovary. Serous adenocarcinoma is the most common histologic variant. It affects women almost exclusively. The diagnosis of primary peritoneal carcinoma can be made only if both ovaries are not involved by tumor, or, if the ovaries are involved, the tumor is confined to the ovarian surface without invasion of the ovarian stroma and the peritoneal involvement is greater than the ovarian surface involvement." [NCIT:P378] +synonym: "carcinoma of peritoneum" EXACT [MONDO:patterns/carcinoma] +synonym: "peritoneum carcinoma" EXACT [MONDO:patterns/location] +synonym: "primary peritoneal carcinoma" NARROW [DOID:1791] +xref: DOID:1791 {source="MONDO:equivalentTo"} +xref: SCTID:447781009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002087 ! peritoneum cancer +is_a: MONDO:0004993 ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002358 ! peritoneum +property_value: exactMatch DOID:1791 +property_value: exactMatch http://identifiers.org/snomedct/447781009 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002114 +name: pancreas lymphoma +def: "A lymphoma that arises from the pancreas with the bulk of the tumor localized to this organ. The vast majority of cases are non-Hodgkin lymphomas of B-cell phenotype and include mucosa-associated lymphoid tissue lymphomas, follicular lymphomas, and diffuse large B-cell lymphomas." [NCIT:C5714] +synonym: "lymphoma of pancreas" EXACT [DOID:1792, NCIT:C5714] +synonym: "lymphoma of the pancreas" EXACT [NCIT:C5714] +synonym: "pancreas lymphoma" EXACT [MONDO:patterns/location] +synonym: "pancreatic lymphoma" EXACT [NCIT:C5714] +xref: DOID:1792 {source="MONDO:equivalentTo"} +xref: NCIT:C5714 {source="DOID:1792", source="MONDO:equivalentTo"} +xref: UMLS:C1335307 {source="DOID:1792", source="MONDO:equivalentTo", source="NCIT:C5714"} +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C5714"} ! gastrointestinal lymphoma +is_a: MONDO:0009831 {source="DOID:1792", source="MONDO:Redundant", source="NCIT:C5714"} ! malignant pancreatic neoplasm +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001264 ! pancreas +property_value: exactMatch DOID:1792 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335307 +property_value: exactMatch NCIT:C5714 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0002116 +name: malignant exocrine pancreas neoplasm +def: "A malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue." [NCIT:C7430] +synonym: "cancer of exocrine pancreas" EXACT [MONDO:patterns/cancer] +synonym: "exocrine pancreas cancer" EXACT [MONDO:patterns/location] +synonym: "malignant exocrine pancreas neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7430] +synonym: "malignant exocrine pancreas tumor" EXACT [NCIT:C7430] +synonym: "malignant neoplasm of exocrine pancreas" EXACT [MONDO:patterns/cancer, NCIT:C7430] +synonym: "malignant neoplasm of the exocrine pancreas" EXACT [DOID:1795, NCIT:C7430] +synonym: "malignant tumor of exocrine pancreas" EXACT [DOID:1795, NCIT:C7430] +synonym: "malignant tumor of the exocrine pancreas" EXACT [NCIT:C7430] +synonym: "pancreatic exocrine tumor" BROAD [DOID:1795] +synonym: "tumor of exocrine pancreas" RELATED [DOID:1795] +xref: DOID:1795 {source="MONDO:equivalentTo"} +xref: NCIT:C7430 {source="MONDO:equivalentTo"} +xref: SCTID:255088001 {source="DOID:1795", source="MONDO:equivalentTo"} +xref: UMLS:C0346648 {source="NCIT:C7430", source="DOID:1795", source="MONDO:equivalentTo"} +is_a: MONDO:0009831 {source="DOID:1795", source="MONDO:Redundant", source="NCIT:C7430"} ! malignant pancreatic neoplasm +is_a: MONDO:0021076 {source="MONDO:Redundant", source="NCIT:C7430"} ! pancreatic exocrine neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000017 ! exocrine pancreas +property_value: exactMatch DOID:1795 +property_value: exactMatch http://identifiers.org/snomedct/255088001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346648 +property_value: exactMatch NCIT:C7430 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002118 +name: urinary system disorder +def: "A disease involving the renal system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of renal system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of renal system" EXACT [] +synonym: "disease, urinary tract" EXACT [MESH:D014570] +synonym: "disease, urologic" EXACT [MESH:D014570] +synonym: "disease, urological" EXACT [MESH:D014570] +synonym: "diseases, urinary tract" EXACT [MESH:D014570] +synonym: "diseases, urologic" EXACT [MESH:D014570] +synonym: "diseases, urological" EXACT [MESH:D014570] +synonym: "disorder of renal system" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the urinary system" EXACT [] +synonym: "disorder of urinary system" EXACT [NCIT:C3430] +synonym: "non-neoplastic urinary tract disease" EXACT [DOID:18, NCIT:C27599] +synonym: "renal system disease" EXACT [MONDO:patterns/location] +synonym: "renal system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "urinary disease" EXACT [DOID:18] +synonym: "urinary system disease" EXACT [] +synonym: "urinary system disorder" EXACT [] +synonym: "urinary tract disease" EXACT [DOID:18, MESH:D014570] +synonym: "urinary tract diseases" EXACT [MESH:D014570] +synonym: "urinary tract disorder" EXACT [NCIT:C3430] +synonym: "urologic disease" EXACT [MESH:D014570] +synonym: "urologic disorder" EXACT [NCIT:C3430] +synonym: "urological disease" EXACT [MESH:D014570] +synonym: "urological diseases" EXACT [MESH:D014570] +synonym: "urological disorder" EXACT [] +synonym: "urological disorders" EXACT [NCIT:C3430] +xref: DOID:18 {source="MONDO:equivalentTo"} +xref: ICD9:V47.4 {source="MONDO:RelatedTo", source="MONDO:i2s"} +xref: MESH:D014570 {source="MONDO:equivalentTo"} +xref: NCIT:C3430 {source="MONDO:equivalentTo"} +xref: SCTID:128606002 {source="MONDO:equivalentTo"} +xref: UMLS:C1335051 {source="MONDO:equivalentTo", source="DOID:18"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001008 ! renal system +relationship: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch DOID:18 +property_value: exactMatch http://identifiers.org/mesh/D014570 +property_value: exactMatch http://identifiers.org/snomedct/128606002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335051 +property_value: exactMatch NCIT:C3430 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002120 +name: neuroendocrine carcinoma +def: "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma." [NCIT:C3773] +synonym: "NEC" EXACT ABBREVIATION [NCIT:C3773] +synonym: "neuroendocrine cancer" EXACT [NCIT:C3773] +synonym: "neuroendocrine carcinoma" EXACT [NCIT:C3773] +xref: DOID:1800 {source="MONDO:equivalentTo"} +xref: ICDO:8246/3 {source="NCIT:C3773"} +xref: MESH:D018278 {source="MONDO:equivalentTo", source="DOID:1800"} +xref: NCIT:C3773 {source="MONDO:equivalentTo", source="DOID:1800", source="MONDO:exact-label-match"} +xref: SCTID:253000007 {source="MONDO:equivalentTo", source="DOID:1800"} +xref: UMLS:C0206695 {source="MONDO:equivalentTo", source="NCIT:C3773", source="DOID:1800"} +is_a: MONDO:0004993 {source="DOID:1800", source="MESH:D018278/inferred", source="MONDO:Redundant", source="NCIT:C3773"} ! carcinoma +is_a: MONDO:0019496 {source="MESH:D018278", source="MONDO:Redundant", source="NCIT:C3773"} ! neuroendocrine neoplasm +is_a: MONDO:0021069 {source="MONDO:Redundant", source="NCIT:C3773"} ! malignant endocrine neoplasm +intersection_of: MONDO:0004993 {source="NCIT:C3773"} ! carcinoma +intersection_of: MONDO:0019496 {source="NCIT:C3773"} ! neuroendocrine neoplasm +intersection_of: MONDO:0021069 {source="NCIT:C3773"} ! malignant endocrine neoplasm +property_value: exactMatch DOID:1800 +property_value: exactMatch http://identifiers.org/mesh/D018278 +property_value: exactMatch http://identifiers.org/snomedct/253000007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206695 +property_value: exactMatch NCIT:C3773 + +[Term] +id: MONDO:0002122 +name: neuritis +def: "A neuropathy arising from inflammation of one or more nerves." [MONDO:cjm] +synonym: "nerve inflammation" EXACT [] +synonym: "peripheral neuritis" EXACT [DOID:1803] +xref: DOID:1803 {source="MONDO:equivalentTo"} +xref: ICD9:729.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009443 {source="MONDO:equivalentTo", source="DOID:1803"} +xref: NCIT:C116381 {source="MONDO:equivalentTo", source="DOID:1803"} +xref: SCTID:128192007 {source="MONDO:equivalentTo", source="DOID:1803"} +xref: SCTID:84299009 {source="MONDO:equivalentObsolete", source="DOID:1803"} +xref: UMLS:C0027813 {source="MONDO:equivalentTo", source="DOID:1803", source="NCIT:C116381"} +is_a: MONDO:0005244 {source="DOID:1803", source="MONDO:Redundant", source="NCIT:C116381"} ! peripheral neuropathy +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_inflammation_site UBERON:0001021 ! nerve +relationship: disease_has_inflammation_site UBERON:0001021 ! nerve +property_value: exactMatch DOID:1803 +property_value: exactMatch http://identifiers.org/mesh/D009443 +property_value: exactMatch http://identifiers.org/snomedct/128192007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027813 +property_value: exactMatch NCIT:C116381 + +[Term] +id: MONDO:0002129 +name: bone cancer +def: "A primary or metastatic malignant neoplasm affecting the bone or articular cartilage." [NCIT:C4016] +synonym: "bone cancer" EXACT [NCIT:C4016] +synonym: "bone neoplasm" BROAD [DOID:184] +synonym: "bone tumour" BROAD [DOID:184] +synonym: "CA - bone cancer" EXACT [DOID:184] +synonym: "cancer of bone" EXACT [NCIT:C4016] +synonym: "cancer of skeletal element" EXACT [MONDO:patterns/cancer] +synonym: "cancer of the bone" EXACT [NCIT:C4016] +synonym: "malignant bone neoplasm" EXACT [DOID:184, NCIT:C4016] +synonym: "malignant bone tumor" EXACT [NCIT:C4016] +synonym: "malignant bone tumour" EXACT [DOID:184] +synonym: "malignant neoplasm of bone" EXACT [DOID:184, NCIT:C4016] +synonym: "malignant neoplasm of skeletal element" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the bone" EXACT [NCIT:C4016] +synonym: "malignant osseous neoplasm" EXACT [NCIT:C4016] +synonym: "malignant osseous tumor" EXACT [DOID:184, NCIT:C4016] +synonym: "malignant skeletal element neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of bone" EXACT [NCIT:C4016] +synonym: "malignant tumor of the bone" EXACT [NCIT:C4016] +synonym: "osseous cancer" EXACT [NCIT:C4016] +synonym: "osseous tumor" BROAD [DOID:184, NCIT:C9343] +synonym: "skeletal element cancer" EXACT [MONDO:patterns/location] +xref: CSP:2019-1041 {source="DOID:184"} +xref: DOID:184 {source="MONDO:equivalentTo"} +xref: ICD9:170.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001859 {source="MONDO:equivalentTo", source="DOID:184"} +xref: NCIT:C4016 {source="MONDO:equivalentTo"} +xref: SCTID:428281000 {source="MONDO:equivalentTo"} +is_a: MONDO:0000637 ! musculoskeletal system cancer +is_a: MONDO:0019060 {source="NCIT:C4016"} ! bone neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004765 ! skeletal element +relationship: disease_has_location UBERON:0004765 ! skeletal element +property_value: exactMatch DOID:184 +property_value: exactMatch http://identifiers.org/mesh/D001859 +property_value: exactMatch http://identifiers.org/snomedct/428281000 +property_value: exactMatch NCIT:C4016 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002131 +name: jaw cancer +def: "A malignant neoplasm involving the jaw skeleton" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of jaw skeleton" EXACT [MONDO:patterns/cancer] +synonym: "jaw neoplasm" BROAD [DOID:1862] +synonym: "jaw skeleton cancer" EXACT [MONDO:patterns/location] +synonym: "malignant jaw skeleton neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of jaw skeleton" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of jaw" BROAD [DOID:1862] +xref: DOID:1862 {source="MONDO:equivalentTo"} +xref: EFO:0007333 {source="MONDO:equivalentTo"} +xref: MESH:D007573 {source="MONDO:equivalentTo", source="DOID:1862"} +is_a: MONDO:0002132 ! skull cancer +is_a: MONDO:0002516 ! digestive system cancer +is_a: MONDO:0021580 ! neoplasm of jaw +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001708 ! jaw skeleton +property_value: exactMatch DOID:1862 +property_value: exactMatch http://identifiers.org/mesh/D007573 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002132 +name: skull cancer +def: "A malignant neoplasm involving the skull." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of skull" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of skull" EXACT [MONDO:patterns/cancer] +synonym: "malignant skull neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "skull cancer" EXACT [MONDO:patterns/location] +xref: DOID:1863 {source="MONDO:equivalentTo"} +is_a: MONDO:0002129 {source="DOID:1863", source="MONDO:Redundant"} ! bone cancer +is_a: MONDO:0005627 ! head and neck cancer +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003129 ! skull +property_value: exactMatch DOID:1863 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002133 +name: chronic rheumatic pericarditis +def: "Chronic form of rheumatic pericarditis." [MONDO:patterns/chronic] +synonym: "rheumatic pericarditis, chronic" EXACT [MONDO:design_pattern, MONDO:patterns/chronic] +xref: DOID:1869 {source="MONDO:equivalentTo"} +xref: ICD10CM:I09.2 {source="MONDO:equivalentTo", source="DOID:1869"} +xref: ICD9:393 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1869"} +xref: SCTID:78069008 {source="MONDO:equivalentTo", source="DOID:1869"} +xref: UMLS:C0155561 {source="MONDO:equivalentTo", source="DOID:1869"} +is_a: MONDO:0024655 ! rheumatic pericarditis +intersection_of: MONDO:0024655 ! rheumatic pericarditis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:1869 +property_value: exactMatch http://identifiers.org/snomedct/78069008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155561 +property_value: exactMatch https://icd.codes/icd10cm/I09.2 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002134 +name: physiological sexual disorder +def: "Physiological disturbances in normal sexual performance in either the male or the female." [MESH:D012735] +synonym: "physiological sexual disorder" EXACT [MESH:D012735] +synonym: "physiological sexual disorders" RELATED [MESH:D012735] +synonym: "physiological sexual dysfunction" EXACT [MESH:D012735] +synonym: "physiological sexual dysfunctions" RELATED [MESH:D012735] +synonym: "Sex disorders" BROAD [MESH:D012735] +synonym: "sexual disorder, physiological" RELATED [MESH:D012735] +synonym: "sexual disorders, physiological" RELATED [MESH:D012735] +synonym: "sexual dysfunction" BROAD [DOID:1876] +synonym: "sexual dysfunctions, physiological" RELATED [MESH:D012735] +xref: DOID:1876 {source="MONDO:equivalentTo"} +xref: MESH:D012735 {source="MONDO:equivalentTo", source="DOID:1876"} +xref: NCIT:C3347 {source="MONDO:otherHierarchy", source="DOID:1876", source="MONDO:exact-label-match"} +xref: UMLS:C0549622 {source="MONDO:equivalentTo", source="DOID:1876", source="NCIT:C3347"} +is_a: MONDO:0005039 {source="https://github.com/monarch-initiative/mondo/issues/723", source="https://orcid.org/0000-0001-5208-3432"} ! reproductive system disorder +property_value: exactMatch DOID:1876 +property_value: exactMatch http://identifiers.org/mesh/D012735 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0549622 +property_value: excluded_subClassOf MONDO:0000595 {source="DOID:1876"} +property_value: relatedMatch NCIT:C3347 + +[Term] +id: MONDO:0002135 +name: optic nerve disorder +def: "A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve)." [NCIT:C79698] +synonym: "cranial nerve II disease" EXACT [MONDO:patterns/location] +synonym: "cranial nerve II disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of cranial nerve II" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cranial nerve II" EXACT [] +synonym: "disorder of cranial nerve II" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the second nerve" EXACT [DOID:1891] +synonym: "optic nerve disorder" EXACT [DOID:1891, NCIT:C79698] +synonym: "optic neuropathy" EXACT [DOID:1891] +synonym: "second cranial nerve disorder" EXACT [NCIT:C79698] +xref: DOID:1891 {source="MONDO:equivalentTo"} +xref: ICD9:377.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:377.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009901 {source="DOID:1891", source="MONDO:equivalentTo"} +xref: NCIT:C79698 {source="DOID:1891", source="MONDO:equivalentTo"} +xref: SCTID:77157004 {source="DOID:1891", source="MONDO:equivalentTo"} +xref: UMLS:C0029132 {source="DOID:1891", source="MONDO:equivalentTo"} +is_a: MONDO:0002602 ! central nervous system disorder +is_a: MONDO:0003569 {source="DOID:1891", source="MESH:D009901", source="MONDO:Redundant", source="NCIT:C79698"} ! cranial nerve neuropathy +is_a: MONDO:0024458 ! disorder of visual system +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000941 ! cranial nerve II +relationship: disease_has_location UBERON:0000941 ! cranial nerve II +property_value: exactMatch DOID:1891 +property_value: exactMatch http://identifiers.org/mesh/D009901 +property_value: exactMatch http://identifiers.org/snomedct/77157004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029132 +property_value: exactMatch NCIT:C79698 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002145 +name: difference of sexual differentiation +def: "A congenital disorder characterized by abnormalities in the development of the sexual characteristics." [NCIT:C103186] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:90771"} +synonym: "CARD" BROAD ABBREVIATION [NCIT:C103186] +synonym: "conditions affecting reproductive development" EXACT [NCIT:C103186] +synonym: "differences of sex development" EXACT [NCIT:C103186] +synonym: "disorder of sex development" EXACT [MONDO:0019592] +synonym: "disorder of sex differentiation" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of sexual differentiation" EXACT [NCIT:C103186] +synonym: "disorders of sex development" EXACT [NCIT:C103186] +synonym: "disorders of sex development (DSD)" RELATED [GTR:AN1172969] +synonym: "DSD" BROAD ABBREVIATION [Orphanet:90771] +synonym: "intersex" EXACT [NCIT:C103186] +synonym: "intersex conditions" EXACT [NCIT:C103186] +synonym: "sex differentiation disease" EXACT [DOID:1923] +synonym: "sex differentiation disorder" EXACT [DOID:1923] +synonym: "sexual differentiation disorder" EXACT [NCIT:C103186] +xref: DOID:1923 {source="MONDO:equivalentTo"} +xref: GTR:AN1172969 {source="UMLS:CN757797"} +xref: MedDRA:10070597 {source="Orphanet:90771", source="Orphanet:90771/e"} +xref: MESH:D012734 {source="MONDO:equivalentTo", source="Orphanet:90771", source="DOID:1923", source="Orphanet:90771/e"} +xref: NCIT:C103186 {source="MONDO:equivalentTo"} +xref: Orphanet:90771 {source="MONDO:equivalentTo"} +xref: SCTID:39179006 {source="MONDO:equivalentTo"} +xref: UMLS:CN757797 {source="MONDO:equivalentTo"} +is_a: MONDO:0002259 {source="DOID:1923", source="MESH:D012734"} ! gonadal disorder +is_a: MONDO:0019755 {source="Orphanet:90771"} ! developmental defect during embryogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0007548 ! sex differentiation +relationship: disease_has_basis_in_disruption_of GO:0007548 ! sex differentiation +property_value: closeMatch http://identifiers.org/meddra/10070597 +property_value: exactMatch DOID:1923 +property_value: exactMatch http://identifiers.org/mesh/D012734 +property_value: exactMatch http://identifiers.org/snomedct/39179006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN757797 +property_value: exactMatch NCIT:C103186 +property_value: exactMatch Orphanet:90771 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4091 xsd:string + +[Term] +id: MONDO:0002146 +name: hypogonadism +def: "A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation." [NCIT:P378] +synonym: "gonadotropin deficiency" EXACT [NCIT:C9227] +synonym: "hypogonadotropism" EXACT [NCIT:C9227] +xref: DOID:1924 {source="MONDO:equivalentTo"} +xref: ICD9:253.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007006 {source="MONDO:equivalentTo", source="DOID:1924"} +xref: NCIT:C9227 {source="MONDO:equivalentTo", source="DOID:1924"} +xref: SCTID:48130008 {source="MONDO:equivalentTo", source="DOID:1924"} +xref: UMLS:C0020619 {source="MONDO:equivalentTo", source="NCIT:C9227", source="DOID:1924"} +is_a: MONDO:0002259 {source="DOID:1924", source="MESH:D007006", source="NCIT:C9227/inferred"} ! gonadal disorder +property_value: exactMatch DOID:1924 +property_value: exactMatch http://identifiers.org/mesh/D007006 +property_value: exactMatch http://identifiers.org/snomedct/48130008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020619 +property_value: exactMatch NCIT:C9227 + +[Term] +id: MONDO:0002149 +name: reproductive system cancer +def: "A malignant neoplasm involving the reproductive organ" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "cancer of reproductive system" EXACT [DOID:193, MONDO:patterns/cancer] +synonym: "malignant neoplasm of reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of reproductive system" EXACT [MONDO:patterns/cancer] +synonym: "malignant reproductive organ neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant reproductive system neoplasm" EXACT [DOID:193, MONDO:patterns/cancer, NCIT:C36076] +synonym: "reproductive organ cancer" EXACT [MONDO:patterns/location] +synonym: "reproductive system cancer" EXACT [] +synonym: "reproductive tumor" BROAD [DOID:193, NCIT:C3674] +xref: DOID:193 {source="MONDO:equivalentTo"} +xref: NCIT:C36076 {source="MONDO:equivalentTo"} +xref: UMLS:C1334618 {source="NCIT:C36076", source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:193", source="DOID:193/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0006054 {source="MONDO:Redundant", source="NCIT:C36076"} ! reproductive system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000990 ! reproductive system +property_value: exactMatch DOID:193 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334618 +property_value: exactMatch NCIT:C36076 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002150 +name: hypothalamic disorder +def: "Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; autonomic nervous system diseases; sleep disorders; behavioral symptoms related to dysfunction of the limbic system; and neuroendocrine disorders." [MESH:D007027] +synonym: "disease of hypothalamus" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of hypothalamus" EXACT [] +synonym: "disorder of hypothalamus" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "hypothalamus disease" EXACT [MONDO:design_pattern] +synonym: "hypothalamus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1931 {source="MONDO:equivalentTo"} +xref: ICD9:253.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007027 {source="MONDO:equivalentTo", source="DOID:1931"} +xref: SCTID:399100005 {source="MONDO:equivalentTo", source="DOID:1931"} +xref: UMLS:C0020655 {source="MONDO:equivalentTo", source="DOID:1931"} +is_a: MONDO:0003081 {source="DOID:1931", source="MONDO:Entailed"} ! thalamic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001898 ! hypothalamus +relationship: disease_has_location UBERON:0001898 ! hypothalamus +property_value: exactMatch DOID:1931 +property_value: exactMatch http://identifiers.org/mesh/D007027 +property_value: exactMatch http://identifiers.org/snomedct/399100005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020655 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002155 +name: cholecystitis +def: "An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones." [NCIT:P378] +subset: gard_rare +synonym: "acalculous cholecystitis" RELATED [GARD:0000030] +synonym: "acute and chronic cholecystitis" EXACT [DOID:1949, ICD9CM:575.12] +synonym: "acute cholecystitis" NARROW [DOID:1949, ICD9CM:575.0, NCIT:C35152] +synonym: "acute on chronic cholecystitis" NARROW [DOID:1949] +synonym: "chronic cholecystitis" NARROW [DOID:1949, ICD9CM:575.11] +synonym: "gall bladder inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "gallstone cholecystitis" RELATED [GARD:0000030] +synonym: "inflammation of gall bladder" EXACT [] +xref: DOID:1949 {source="MONDO:equivalentTo"} +xref: GARD:0000030 {source="MONDO:equivalentTo"} +xref: ICD9:575.10 {source="DOID:1949"} +xref: ICD9:575.11 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D002764 {source="DOID:1949", source="MONDO:equivalentTo"} +xref: NCIT:C34465 {source="DOID:1949", source="MONDO:equivalentTo"} +xref: SCTID:20824003 {source="MONDO:equivalentTo"} +is_a: MONDO:0004789 {source="DOID:1949"} ! cholangitis +is_a: MONDO:0005281 {source="MESH:D002764", source="MONDO:Redundant", source="NCIT:C34465/inferred"} ! gallbladder disorder +is_a: MONDO:0015509 ! genetic biliary tract disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002110 ! gall bladder +relationship: disease_has_inflammation_site UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:1949 +property_value: exactMatch http://identifiers.org/mesh/D002764 +property_value: exactMatch http://identifiers.org/snomedct/20824003 +property_value: exactMatch NCIT:C34465 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002156 +name: fallopian tube disorder +def: "A disease involving the fallopian tube." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of fallopian tube" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of fallopian tube" EXACT [] +synonym: "disorder of fallopian tube" EXACT [MONDO:patterns/location_top] +synonym: "fallopian tube disease" EXACT [MONDO:patterns/location, NCIT:C26771] +synonym: "fallopian tube disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "fallopian tube disorder" EXACT [NCIT:C26771] +xref: DOID:1962 {source="MONDO:equivalentTo"} +xref: MESH:D005184 {source="DOID:1962", source="MONDO:equivalentTo"} +xref: NCIT:C26771 {source="DOID:1962", source="MONDO:equivalentTo"} +xref: SCTID:128134005 {source="DOID:1962", source="MONDO:equivalentTo"} +xref: UMLS:C0015556 {source="NCIT:C26771", source="DOID:1962", source="MONDO:equivalentTo"} +is_a: MONDO:0002263 {source="DOID:1962", source="MESH:D005184/inferred", source="MONDO:Redundant", source="NCIT:C26771"} ! female reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +relationship: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:1962 +property_value: exactMatch http://identifiers.org/mesh/D005184 +property_value: exactMatch http://identifiers.org/snomedct/128134005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015556 +property_value: exactMatch NCIT:C26771 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002158 +name: fallopian tube cancer +def: "A primary or metastatic malignant neoplasm that affects the fallopian tube. Representative examples include carcinoma, carcinosarcoma, and leiomyosarcoma." [NCIT:C7480] +subset: ordo_disease {source="Orphanet:180242"} +synonym: "cancer of fallopian tube" EXACT [MONDO:patterns/cancer] +synonym: "cancer of fallopian tubes" EXACT [Orphanet:180242] +synonym: "fallopian tube cancer" EXACT [MONDO:patterns/location] +synonym: "fallopian tube malignant neoplasm" EXACT [NCIT:C7480] +synonym: "fallopian tube malignant tumor" EXACT [NCIT:C7480] +synonym: "malignant fallopian tube neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7480] +synonym: "malignant fallopian tube tumor" EXACT [NCIT:C7480] +synonym: "malignant neoplasm of fallopian tube" EXACT [MONDO:patterns/cancer, NCIT:C7480] +synonym: "malignant neoplasm of the fallopian tube" EXACT [NCIT:C7480] +synonym: "malignant neoplasm of uterine tube" EXACT [DOID:1964] +synonym: "malignant tubal tumor" EXACT [Orphanet:180242] +synonym: "malignant tumor of fallopian tube" EXACT [NCIT:C7480] +synonym: "malignant tumor of fallopian tubes" EXACT [MONDO:0015866] +synonym: "malignant tumor of the fallopian tube" EXACT [NCIT:C7480] +synonym: "malignant tumour of fallopian tube" EXACT [DOID:1964] +synonym: "neoplasm, fallopian tube, malignant" EXACT [NCIT:C7480] +synonym: "tubal cancer" EXACT [Orphanet:180242] +synonym: "tumor of the fallopian tube" BROAD [DOID:1964, NCIT:C3032] +synonym: "tumor, fallopian tube, malignant" EXACT [DOID:1964, NCIT:C7480] +xref: DOID:1964 {source="MONDO:equivalentTo"} +xref: GARD:0009162 {source="MONDO:equivalentTo"} +xref: ICD9:183.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1964"} +xref: MedDRA:10025915 {source="Orphanet:180242", source="Orphanet:180242/e"} +xref: NCIT:C7480 {source="MONDO:equivalentTo", source="DOID:1964"} +xref: Orphanet:180242 {source="MONDO:equivalentTo"} +xref: SCTID:363444001 {source="MONDO:equivalentTo", source="DOID:1964"} +xref: UMLS:C0153579 {source="MONDO:equivalentTo", source="DOID:1964", source="Orphanet:180242", source="NCIT:C7480", source="Orphanet:180242/e"} +xref: UMLS:CN200469 {source="MONDO:equivalentTo"} +is_a: MONDO:0001416 {source="DOID:1964", source="MONDO:Redundant", source="NCIT:C7480"} ! female reproductive organ cancer +is_a: MONDO:0021092 {source="MONDO:Redundant", source="NCIT:C7480"} ! fallopian tube neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: closeMatch http://identifiers.org/meddra/10025915 +property_value: exactMatch DOID:1964 +property_value: exactMatch http://identifiers.org/snomedct/363444001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153579 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200469 +property_value: exactMatch NCIT:C7480 +property_value: exactMatch Orphanet:180242 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002165 +name: rectal neoplasm +def: "A benign or malignant neoplasm that affects the rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Rectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." [NCIT:C3350] +synonym: "neoplasm of rectum" EXACT [MONDO:patterns/neoplasm, NCIT:C3350] +synonym: "neoplasm of the rectum" EXACT [NCIT:C3350] +synonym: "rectal neoplasm" EXACT [NCIT:C3350] +synonym: "rectal tumor" EXACT [DOID:1984, NCIT:C3350] +synonym: "rectum neoplasm" EXACT [DOID:1984] +synonym: "rectum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "rectum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of rectum" EXACT [MONDO:patterns/neoplasm, NCIT:C3350] +synonym: "tumor of the rectum" EXACT [NCIT:C3350] +xref: DOID:1984 {source="MONDO:equivalentTo"} +xref: MESH:D012004 {source="DOID:1984", source="MONDO:equivalentTo"} +xref: NCIT:C3350 {source="DOID:1984", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126847008 {source="DOID:1984", source="MONDO:equivalentTo"} +xref: UMLS:C0034885 {source="NCIT:C3350", source="DOID:1984", source="MONDO:equivalentTo"} +is_a: MONDO:0001593 {source="MESH:D012004/inferred", source="MONDO:Redundant"} ! rectal disorder +is_a: MONDO:0005335 {source="MESH:D012004", source="NCIT:C3350"} ! colorectal neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch DOID:1984 +property_value: exactMatch http://identifiers.org/mesh/D012004 +property_value: exactMatch http://identifiers.org/snomedct/126847008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034885 +property_value: exactMatch NCIT:C3350 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002166 +name: rectum lymphoma +def: "An extranodal lymphoma that arises from the rectum. The majority are B-cell non-Hodgkin lymphomas." [NCIT:C5553] +synonym: "lymphoma of rectum" EXACT [DOID:1988, NCIT:C5553] +synonym: "lymphoma of the rectum" EXACT [NCIT:C5553] +synonym: "primary rectal lymphoma" EXACT [NCIT:C5553] +synonym: "rectal lymphoma" EXACT [NCIT:C5553] +synonym: "rectum lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:1988 {source="MONDO:equivalentTo"} +xref: NCIT:C5553 {source="MONDO:equivalentTo", source="DOID:1988"} +xref: UMLS:C1335685 {source="MONDO:equivalentTo", source="NCIT:C5553", source="DOID:1988"} +is_a: MONDO:0006519 {source="DOID:1988", source="MONDO:Redundant", source="NCIT:C5553"} ! rectal cancer +is_a: MONDO:0024656 {source="MONDO:Redundant", source="NCIT:C5553"} ! colorectal lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch DOID:1988 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335685 +property_value: exactMatch NCIT:C5553 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0002169 +name: rectum adenocarcinoma +def: "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." [NCIT:C9383] +synonym: "adenocarcinoma - rectum" EXACT [NCIT:C9383] +synonym: "adenocarcinoma of rectum" EXACT [DOID:1996, NCIT:C9383] +synonym: "adenocarcinoma of the rectum" EXACT [NCIT:C9383] +synonym: "read" RELATED [ONCOTREE:READ] +synonym: "rectal adenocarcinoma" EXACT [DOID:1996, MONDO:0005540, NCIT:C9383] +synonym: "rectum adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:1996 {source="MONDO:equivalentTo"} +xref: EFO:0005631 {source="MONDO:equivalentTo"} +xref: NCIT:C9383 {source="EFO:0005631", source="MONDO:equivalentTo", source="DOID:1996"} +xref: ONCOTREE:READ {source="MONDO:equivalentTo"} +xref: SCTID:254582000 {source="EFO:0005631", source="MONDO:equivalentTo", source="DOID:1996"} +xref: UMLS:C0149978 {source="MONDO:equivalentTo", source="DOID:1996", source="NCIT:C9383"} +is_a: MONDO:0005008 {source="DOID:1996", source="MONDO:Redundant", source="NCIT:C9383", source="ONCOTREE:READ"} ! colorectal adenocarcinoma +is_a: MONDO:0044937 ! rectal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch DOID:1996 +property_value: exactMatch http://identifiers.org/snomedct/254582000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149978 +property_value: exactMatch NCIT:C9383 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002170 +name: chronic eustachian salpingitis +def: "Chronic form of otosalpingitis." [MONDO:patterns/chronic] +synonym: "chronic eustachian tube salpingitis" EXACT [DOID:1999] +synonym: "chronic otosalpingitis" EXACT [MONDO:design_pattern] +synonym: "otosalpingitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:1999 {source="MONDO:equivalentTo"} +xref: ICD9:381.52 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1999"} +xref: SCTID:194269002 {source="MONDO:equivalentTo", source="DOID:1999"} +xref: UMLS:C0155430 {source="MONDO:equivalentTo", source="DOID:1999"} +is_a: MONDO:0002172 {source="DOID:1999", source="MONDO:Redundant"} ! otosalpingitis +is_a: MONDO:0021204 ! chronic otitis media +intersection_of: MONDO:0002172 ! otosalpingitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:1999 +property_value: exactMatch http://identifiers.org/snomedct/194269002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155430 + +[Term] +id: MONDO:0002172 +name: otosalpingitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the pharyngotympanic tube." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "Eustachian salpingitis" EXACT [DOID:2000, ICD9CM:381.5] +synonym: "Eustachian tube salpingitis" EXACT [DOID:2000] +synonym: "inflammation of pharyngotympanic tube" EXACT [] +synonym: "pharyngotympanic tube inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2000 {source="MONDO:equivalentTo"} +xref: ICD10CM:H68.0 {source="DOID:2000", source="MONDO:equivalentTo"} +xref: ICD9:381.5 {source="DOID:2000"} +xref: ICD9:381.50 {source="DOID:2000", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:270491006 {source="DOID:2000", source="MONDO:equivalentTo"} +xref: UMLS:C0155428 {source="DOID:2000", source="MONDO:equivalentTo"} +is_a: MONDO:0004866 {source="DOID:2000", source="MONDO:Redundant"} ! eustachian tube disorder +is_a: MONDO:0005441 ! otitis media +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002393 ! pharyngotympanic tube +relationship: disease_has_inflammation_site UBERON:0002393 ! pharyngotympanic tube +property_value: exactMatch DOID:2000 +property_value: exactMatch http://identifiers.org/snomedct/270491006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155428 +property_value: exactMatch https://icd.codes/icd10cm/H68.0 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002178 +name: placenta cancer +def: "A malignant neoplasm involving the placenta." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of placenta" EXACT [MONDO:patterns/cancer] +synonym: "deciduoma, malignant" EXACT [NCIT:C3555] +synonym: "malignant neoplasm of placenta" EXACT [DOID:2021, ICD9CM:181, MONDO:patterns/cancer] +synonym: "malignant neoplasm of the placenta" EXACT [NCIT:C3555] +synonym: "malignant placenta neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant placenta tumor" EXACT [NCIT:C3555] +synonym: "malignant placental neoplasm" EXACT [NCIT:C3555] +synonym: "malignant placental tumor" EXACT [DOID:2021, NCIT:C3555] +synonym: "malignant tumor of placenta" EXACT [NCIT:C3555] +synonym: "malignant tumor of the placenta" EXACT [NCIT:C3555] +synonym: "placenta cancer" EXACT [MONDO:patterns/location] +synonym: "placental cancer" EXACT [DOID:2021] +synonym: "placental tumors" BROAD [DOID:2021, NCIT:C4858] +synonym: "primary malignant neoplasm of placenta" EXACT [DOID:2021] +xref: DOID:2021 {source="MONDO:equivalentTo"} +xref: ICD9:181 {source="DOID:2021", source="MONDO:relatedTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3555 {source="DOID:2021", source="MONDO:equivalentTo"} +xref: SCTID:126920004 {source="MONDO:equivalentTo"} +xref: UMLS:C0153572 {source="DOID:2021", source="MONDO:equivalentTo", source="NCIT:C3555"} +is_a: MONDO:0002715 ! uterine cancer +is_a: MONDO:0021218 {source="MONDO:Redundant", source="NCIT:C3555"} ! placenta neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001987 ! placenta +property_value: exactMatch DOID:2021 +property_value: exactMatch http://identifiers.org/snomedct/126920004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153572 +property_value: exactMatch NCIT:C3555 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002184 +name: drug-induced hepatitis +def: "Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an idiosyncratic response to a drug or metabolite." [MESH:D056487] +synonym: "drug-induced chronic hepatitis" EXACT [DOID:2044] +xref: DOID:2044 {source="MONDO:equivalentTo"} +xref: EFO:1000905 {source="MONDO:equivalentTo"} +xref: SCTID:235889003 {source="DOID:2044", source="MONDO:equivalentTo"} +is_a: MONDO:0002251 {source="DOID:2044", source="MONDO:Entailed", source="MONDO:Redundant"} ! hepatitis +is_a: MONDO:0005359 ! drug-induced liver injury +intersection_of: MONDO:0002251 ! hepatitis +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch DOID:2044 +property_value: exactMatch http://identifiers.org/snomedct/235889003 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002186 +name: acute maxillary sinusitis +def: "Acute form of maxillary sinusitis." [MONDO:patterns/acute] +synonym: "acute antritis" EXACT [DOID:2050] +synonym: "maxillary sinusitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:2050 {source="MONDO:equivalentTo"} +xref: ICD10CM:J01.0 {source="MONDO:equivalentTo", source="DOID:2050"} +xref: ICD9:461.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2050"} +xref: SCTID:68272006 {source="MONDO:equivalentTo", source="DOID:2050"} +xref: UMLS:C0155804 {source="MONDO:equivalentTo", source="DOID:2050"} +is_a: MONDO:0005842 {source="DOID:2050", source="MONDO:Redundant"} ! maxillary sinusitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0005842 ! maxillary sinusitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:2050 +property_value: exactMatch http://identifiers.org/snomedct/68272006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155804 +property_value: exactMatch https://icd.codes/icd10cm/J01.0 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0002187 +name: vulvar disease +def: "A non-neoplastic or neoplastic disorder that affects the vulva. Representative examples include infection, Bartholin gland adenoma, and vulvar carcinoma." [NCIT:P378] +synonym: "disorder of vulva" EXACT [] +synonym: "vulval disorder" RELATED [] +synonym: "vulvar disease" EXACT [NCIT:C27631] +synonym: "vulvar disorder" EXACT [NCIT:C27631] +xref: DOID:2059 {source="MONDO:equivalentTo"} +xref: MESH:D014845 {source="DOID:2059", source="MONDO:equivalentTo"} +xref: NCIT:C27631 {source="DOID:2059", source="MONDO:equivalentTo"} +xref: SCTID:5089007 {source="DOID:2059", source="MONDO:equivalentTo"} +xref: UMLS:C0042994 {source="DOID:2059", source="NCIT:C27631", source="MONDO:equivalentTo"} +is_a: MONDO:0002263 {source="DOID:2059", source="MESH:D014845", source="NCIT:C27631"} ! female reproductive system disorder +property_value: exactMatch DOID:2059 +property_value: exactMatch http://identifiers.org/mesh/D014845 +property_value: exactMatch http://identifiers.org/snomedct/5089007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042994 +property_value: exactMatch NCIT:C27631 + +[Term] +id: MONDO:0002193 +name: Bartholin gland benign neoplasm +def: "A benign neoplasm that affects the Bartholin gland. Representative examples include adenoma, adenomyoma, adenocarcinoma, and squamous cell carcinoma." [NCIT:P378] +synonym: "Bartholin gland neoplasm" BROAD [DOID:2068] +synonym: "major vestibular gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "tumor of Bartholin's gland" BROAD [DOID:2068, NCIT:C6434] +xref: DOID:2068 {source="MONDO:equivalentTo"} +xref: SCTID:189130001 {source="MONDO:equivalentTo"} +is_a: MONDO:0000626 {source="DOID:2068", source="MONDO:Entailed", source="MONDO:Redundant"} ! vestibular gland benign neoplasm +is_a: MONDO:0000652 ! integumentary system benign neoplasm +is_a: MONDO:0021114 ! Bartholin gland neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch DOID:2068 +property_value: exactMatch http://identifiers.org/snomedct/189130001 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0002195 +name: vulvar squamous neoplasm +def: "A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vulva. Representative examples include vestibular papilloma, intraepithelial neoplasia, and squamous cell carcinoma." [NCIT:C40283] +synonym: "mammalian vulva squamous cell neoplasm" EXACT [MONDO:patterns/location] +synonym: "vulvar squamous neoplasm" EXACT [NCIT:C40283] +synonym: "vulvar squamous tumor" EXACT [NCIT:C40283] +xref: DOID:2072 {source="MONDO:equivalentTo"} +xref: NCIT:C40283 {source="MONDO:equivalentTo", source="DOID:2072"} +xref: UMLS:C1520097 {source="MONDO:equivalentTo", source="NCIT:C40283", source="DOID:2072"} +is_a: MONDO:0002532 {source="MONDO:Redundant", source="NCIT:C40283"} ! squamous cell neoplasm +is_a: MONDO:0021049 {source="MONDO:Redundant", source="NCIT:C40283"} ! vulvar neoplasm +intersection_of: MONDO:0002532 {source="NCIT:C40283"} ! squamous cell neoplasm +intersection_of: disease_has_location UBERON:0000997 {source="NCIT:C40283"} ! mammalian vulva +relationship: disease_arises_from_structure UBERON:0006914 {source="NCIT:C40283"} ! squamous epithelium +property_value: exactMatch DOID:2072 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1520097 +property_value: exactMatch NCIT:C40283 + +[Term] +id: MONDO:0002198 +name: vulvar glandular neoplasm +def: "A benign or malignant neoplasm that arises from the vulva and is composed of glandular epithelial cells. Representative examples include adenoma of the minor vestibular glands, Bartholin gland adenoma, and Bartholin gland adenocarcinoma." [NCIT:C40292] +synonym: "mammalian vulva glandular cell neoplasm" EXACT [MONDO:patterns/location] +synonym: "vulvar glandular neoplasm" EXACT [NCIT:C40292] +synonym: "vulvar glandular tumor" EXACT [NCIT:C40292] +xref: DOID:2076 {source="MONDO:equivalentTo"} +xref: NCIT:C40292 {source="DOID:2076", source="MONDO:equivalentTo"} +xref: UMLS:C1520082 {source="DOID:2076", source="NCIT:C40292", source="MONDO:equivalentTo"} +is_a: MONDO:0021049 {source="MONDO:Redundant", source="NCIT:C40292"} ! vulvar neoplasm +is_a: MONDO:0024276 {source="MONDO:Redundant", source="NCIT:C40292"} ! glandular cell neoplasm +intersection_of: MONDO:0024276 ! glandular cell neoplasm +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:2076 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1520082 +property_value: exactMatch NCIT:C40292 + +[Term] +id: MONDO:0002203 +name: constipation disorder +def: "Irregular and infrequent or difficult evacuation of the bowels." [NCIT:C37930] +synonym: "colonic inertia" RELATED [MESH:D003248] +synonym: "constipation" EXACT [HP:0002019] +synonym: "Dyschezia" RELATED [MESH:D003248] +xref: DOID:2089 {source="MONDO:equivalentTo"} +xref: HP:0002019 {source="MONDO:otherHierarchy"} +xref: ICD10CM:K59.0 {source="DOID:2089", source="MONDO:equivalentTo"} +xref: ICD9:564.0 {source="DOID:2089", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:564.00 {source="DOID:2089", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D003248 {source="DOID:2089", source="MONDO:equivalentTo"} +xref: NCIT:C37930 {source="DOID:2089", source="MONDO:equivalentTo", source="MONDO:otherHierarchy", source="MONDO:exact-label-match"} +xref: SCTID:14760008 {source="DOID:2089", source="MONDO:equivalentTo"} +is_a: MONDO:0004880 {source="DOID:2089"} ! bowel dysfunction +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_major_feature HP:0002019 ! Constipation +relationship: disease_has_major_feature HP:0002019 ! Constipation +property_value: exactMatch DOID:2089 +property_value: exactMatch http://identifiers.org/mesh/D003248 +property_value: exactMatch http://identifiers.org/snomedct/14760008 +property_value: exactMatch https://icd.codes/icd10cm/K59.0 +property_value: exactMatch NCIT:C37930 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002206 +name: sweat gland cancer +def: "A malignant neoplasm that affects the sweat glands." [NCIT:C4810] +synonym: "cancer of sweat gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sweat gland" EXACT [DOID:2095, MONDO:patterns/cancer, NCIT:C4810] +synonym: "malignant neoplasm of the sweat gland" EXACT [NCIT:C4810] +synonym: "malignant sweat gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4810] +synonym: "malignant tumor of sweat gland" EXACT [NCIT:C4810] +synonym: "malignant tumor of the sweat gland" EXACT [DOID:2095, NCIT:C4810] +synonym: "sweat gland cancer" EXACT [MONDO:patterns/location] +synonym: "sweat gland neoplasms, malignant" EXACT [NCIT:C4810] +xref: DOID:2095 {source="MONDO:equivalentTo"} +xref: NCIT:C4810 {source="MONDO:equivalentTo", source="DOID:2095"} +xref: UMLS:C1321904 {source="MONDO:equivalentTo", source="NCIT:C4810", source="DOID:2095"} +is_a: MONDO:0002381 {source="MONDO:Redundant", source="NCIT:C4810"} ! sweat gland neoplasm +is_a: MONDO:0002898 {source="DOID:2095", source="MONDO:Redundant", source="NCIT:C4810/inferred"} ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001820 ! sweat gland +property_value: exactMatch DOID:2095 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1321904 +property_value: exactMatch NCIT:C4810 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002211 +name: B cell deficiency +def: "A broad classification of disorders where circulating numbers of B lymphocytes are decreased or ineffective. Complement components and the production of antibodies may also be deficient." [NCIT:C4799] +comment: See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/18 +synonym: "B cell (antibody) deficiencies" EXACT [DOID:2115] +synonym: "B-cell deficiency" EXACT [NCIT:C4799] +synonym: "deficiency of humoral immunity" EXACT [NCIT:C4799] +synonym: "immunoglobulin heavy chain deficiency" RELATED [DOID:2115] +synonym: "immunoglobulin heavy chain deletion" RELATED [DOID:2115] +xref: DOID:2115 {source="MONDO:equivalentTo"} +xref: ICD9:279.03 {source="DOID:2115"} +xref: NCIT:C4799 {source="MONDO:equivalentTo", source="NCIT:C4799"} +is_a: MONDO:0003778 {source="DOID:2115"} ! inborn errors of immunity +is_a: MONDO:0004805 ! leukocyte disorder +is_a: MONDO:0021094 {source="NCIT:C4799"} ! immunodeficiency disease +relationship: disease_has_location CL:0000236 ! B cell +property_value: exactMatch DOID:2115 +property_value: exactMatch NCIT:C4799 + +[Term] +id: MONDO:0002218 +name: temporal lobe cancer +def: "A cancer that involves the temporal lobe." [MONDO:patterns/location] +synonym: "cancer of temporal lobe" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of temporal lobe" EXACT [DOID:2135, MONDO:patterns/cancer] +synonym: "malignant temporal lobe neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "temporal lobe cancer" EXACT [MONDO:patterns/location] +synonym: "temporal lobe neoplasm" RELATED [DOID:2135] +xref: DOID:2135 {source="MONDO:equivalentTo", source="MONDO:placement-based-on-DOID-graph"} +xref: ICD10CM:C71.2 {source="DOID:2135", source="MONDO:equivalentTo"} +xref: ICD9:191.2 {source="DOID:2135", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363468009 {source="DOID:2135", source="MONDO:equivalentTo"} +xref: UMLS:C0153636 {source="DOID:2135", source="MONDO:equivalentTo"} +is_a: MONDO:0002731 {source="DOID:2135", source="MONDO:Redundant"} ! cerebral hemisphere cancer +is_a: MONDO:0021372 {source="MONDO:Redundant"} ! neoplasm of temporal lobe +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001871 ! temporal lobe +property_value: exactMatch DOID:2135 +property_value: exactMatch http://identifiers.org/snomedct/363468009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153636 +property_value: exactMatch https://icd.codes/icd10cm/C71.2 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002219 +name: paraurethral gland neoplasm +def: "A neoplasm (disease) that involves the paraurethral gland." [MONDO:patterns/location] +synonym: "neoplasm of paraurethral gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of paraurethral glands" EXACT [DOID:2139] +synonym: "paraurethral gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "paraurethral gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of paraurethral gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the paraurethral gland" EXACT [DOID:2139, NCIT:C4378] +xref: DOID:2139 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:126884005 {source="MONDO:equivalentTo", source="DOID:2139"} +xref: UMLS:C0341766 {source="MONDO:equivalentTo", source="DOID:2139"} +is_a: MONDO:0021049 {source="MONDO:Redundant"} ! vulvar neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0010145 ! paraurethral gland +relationship: disease_has_location UBERON:0010145 ! paraurethral gland +property_value: exactMatch DOID:2139 +property_value: exactMatch http://identifiers.org/snomedct/126884005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341766 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002227 +name: ovarian lymphoma +def: "A lymphoma that affects the ovary. Lymphomatous involvement of the ovary is rare and in approximately half of the cases both ovaries are affected." [NCIT:C40021] +synonym: "lymphoma of ovary" EXACT [MONDO:design_pattern] +synonym: "ovarian lymphoma" EXACT [NCIT:C40021] +synonym: "ovary lymphoma" EXACT [MONDO:patterns/location] +synonym: "primary ovarian lymphoma" EXACT [NCIT:C40021] +xref: DOID:2150 {source="MONDO:equivalentTo"} +xref: NCIT:C40021 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:2150"} +xref: UMLS:C1518720 {source="MONDO:equivalentTo", source="NCIT:C40021", source="DOID:2150"} +is_a: MONDO:0005062 {source="MONDO:Redundant", source="NCIT:C40021/inferred"} ! lymphoma +is_a: MONDO:0008170 {source="DOID:2150", source="NCIT:C40021"} ! ovarian cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:2150 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518720 +property_value: exactMatch NCIT:C40021 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0002229 +name: ovarian epithelial tumor +def: "A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor." [NCIT:C4381] +synonym: "epithelial neoplasm of ovary" EXACT [NCIT:C4381] +synonym: "epithelial neoplasm of the ovary" EXACT [NCIT:C4381] +synonym: "epithelial tumor of ovary" EXACT [DOID:2152, NCIT:C4381] +synonym: "epithelial tumor of the ovary" EXACT [NCIT:C4381] +synonym: "ovarian epithelial tumor" EXACT [NCIT:C4381] +synonym: "ovarian surface epithelial-stromal tumor" EXACT [DOID:2152, NCIT:C4381] +synonym: "ovarian surface-epithelial stromal neoplasm" EXACT [NCIT:C4381] +synonym: "ovary epithelial cancer" RELATED [DOID:2152] +synonym: "ovary epithelial neoplasm" EXACT [MONDO:patterns/location] +synonym: "OVT" RELATED ABBREVIATION [ONCOTREE:OVT] +xref: DOID:2152 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4381 {source="MONDO:equivalentTo", source="DOID:2152"} +xref: ONCOTREE:OVT {source="MONDO:equivalentTo"} +xref: SCTID:237057005 {source="MONDO:equivalentTo", source="DOID:2152"} +xref: UMLS:C0341823 {source="NCIT:C4381", source="MONDO:equivalentTo", source="DOID:2152"} +is_a: MONDO:0005626 {source="MONDO:Redundant", source="NCIT:C4381"} ! epithelial neoplasm +is_a: MONDO:0021068 {source="MONDO:Redundant", source="NCIT:C4381"} ! ovarian neoplasm +intersection_of: MONDO:0005626 {source="NCIT:C4381"} ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0000992 {source="NCIT:C4381"} ! ovary +relationship: disease_arises_from_structure UBERON:0001304 {source="NCIT:C4381"} ! germinal epithelium of ovary +property_value: exactMatch DOID:2152 +property_value: exactMatch http://identifiers.org/snomedct/237057005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341823 +property_value: exactMatch NCIT:C4381 + +[Term] +id: MONDO:0002232 +name: nasal cavity disorder +def: "A disease involving the nasal cavity." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of nasal cavity" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nasal cavity" EXACT [] +synonym: "disorder of nasal cavity" EXACT [MONDO:patterns/location_top] +synonym: "nasal cavity disease" EXACT [MONDO:patterns/location, NCIT:C27102] +synonym: "nasal cavity disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "nasal cavity disorder" EXACT [NCIT:C27102] +xref: DOID:2163 {source="MONDO:equivalentTo"} +xref: NCIT:C27102 {source="MONDO:equivalentTo", source="DOID:2163"} +xref: SCTID:232340005 {source="MONDO:equivalentTo", source="DOID:2163"} +xref: UMLS:C0339820 {source="NCIT:C27102", source="MONDO:equivalentTo", source="DOID:2163"} +is_a: MONDO:0002436 {source="DOID:2163", source="MONDO:Redundant"} ! nasal disorder +is_a: MONDO:0004867 {source="DOID:2163/inferred", source="MONDO:Redundant"} ! upper respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +relationship: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:2163 +property_value: exactMatch http://identifiers.org/snomedct/232340005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339820 +property_value: exactMatch NCIT:C27102 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002234 +name: vaginitis +def: "A non-infectious or infectious inflammatory process affecting the vagina." [NCIT:C26911] +synonym: "inflammation of vagina" EXACT [] +synonym: "vagina inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "vaginal Inflammation" EXACT [NCIT:C26911] +synonym: "vaginal inflammation" EXACT [NCIT:C26911] +synonym: "vaginitis" EXACT [MONDO:ambiguous, NCIT:C26911] +synonym: "vaginitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:2170 {source="MONDO:equivalentTo"} +xref: EFO:0005757 {source="MONDO:equivalentTo"} +xref: HP:0030683 {source="MONDO:otherHierarchy"} +xref: ICD9:616.1 {source="DOID:2170"} +xref: ICD9:616.10 {source="DOID:2170"} +xref: MESH:D014627 {source="MONDO:equivalentTo", source="DOID:2170"} +xref: NCIT:C26911 {source="MONDO:equivalentTo", source="DOID:2170"} +xref: SCTID:30800001 {source="MONDO:equivalentTo", source="DOID:2170"} +xref: UMLS:C0042267 {source="MONDO:equivalentTo", source="DOID:2170", source="NCIT:C26911"} +is_a: MONDO:0001433 {source="DOID:2170", source="MESH:D014627", source="MONDO:Redundant", source="NCIT:C26911/inferred"} ! vaginal disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000996 ! vagina +relationship: disease_has_inflammation_site UBERON:0000996 ! vagina +property_value: exactMatch DOID:2170 +property_value: exactMatch http://identifiers.org/mesh/D014627 +property_value: exactMatch http://identifiers.org/snomedct/30800001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042267 +property_value: exactMatch NCIT:C26911 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "vaginitis (disease)" xsd:string + +[Term] +id: MONDO:0002235 +name: eyelid neoplasm +def: "A benign or malignant neoplasm that affects the eyelid. Representative examples include hemangioma, nevus, and carcinoma." [NCIT:C3031] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98580"} +synonym: "eyelid neoplasm" EXACT [NCIT:C3031] +synonym: "eyelid neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "eyelid tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3031] +synonym: "neoplasm of eyelid" EXACT [MONDO:patterns/neoplasm, NCIT:C3031] +synonym: "neoplasm of the eyelid" EXACT [NCIT:C3031] +synonym: "palpebral tumor" EXACT [MONDO:0020171] +synonym: "tumor of eyelid" EXACT [MONDO:patterns/neoplasm, NCIT:C3031] +synonym: "tumor of the eyelid" EXACT [DOID:2173, NCIT:C3031] +xref: DOID:2173 {source="MONDO:equivalentTo"} +xref: EFO:1000934 {source="MONDO:equivalentTo"} +xref: MESH:D005142 {source="MONDO:equivalentTo", source="DOID:2173"} +xref: NCIT:C3031 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:2173"} +xref: Orphanet:98580 {source="MONDO:equivalentTo"} +xref: SCTID:278697001 {source="MONDO:equivalentTo", source="DOID:2173"} +xref: UMLS:C0015424 {source="NCIT:C3031", source="MONDO:equivalentTo", source="Orphanet:98580", source="DOID:2173"} +is_a: MONDO:0002531 {source="DOID:2173", source="EFO:1000934", source="MONDO:Entailed"} ! skin neoplasm +is_a: MONDO:0003382 {source="MESH:D005142", source="MONDO:Entailed", source="NCIT:C3031", source="Orphanet:98580"} ! eyelid disorder +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C3031"} ! eye neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001711 ! eyelid +relationship: has_modifier MONDO:0021136 {source="MONDO:0020151"} ! rare +property_value: exactMatch DOID:2173 +property_value: exactMatch http://identifiers.org/mesh/D005142 +property_value: exactMatch http://identifiers.org/snomedct/278697001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015424 +property_value: exactMatch NCIT:C3031 +property_value: exactMatch Orphanet:98580 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002236 +name: ocular cancer +def: "A benign or malignant neoplasm affecting the structures of the eye." [NCIT:P378] +comment: Editor note: check to see whether structure is eye or eye + adnexa +synonym: "cancer of eye" EXACT [MONDO:patterns/cancer, NCIT:C4767] +synonym: "cancer of eyeball of camera-type eye" EXACT [MONDO:patterns/cancer] +synonym: "cancer of the eye" EXACT [NCIT:C4767] +synonym: "eye cancer" EXACT [MONDO:patterns/location, NCIT:C4767] +synonym: "eye neoplasm" BROAD [DOID:2174] +synonym: "eye neoplasm, malignant" EXACT [NCIT:C4767] +synonym: "eyeball of camera-type eye cancer" EXACT [] +synonym: "malignant eye neoplasm" EXACT [DOID:2174, MONDO:patterns/cancer, NCIT:C4767] +synonym: "malignant eye tumor" EXACT [NCIT:C4767] +synonym: "malignant eyeball of camera-type eye neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of eye" EXACT [MONDO:patterns/cancer, NCIT:C4767] +synonym: "malignant neoplasm of eyeball of camera-type eye" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the eye" EXACT [NCIT:C4767] +synonym: "malignant ocular neoplasm" EXACT [NCIT:C4767] +synonym: "malignant ocular tumor" EXACT [NCIT:C4767] +synonym: "malignant tumor of eye" EXACT [NCIT:C4767] +synonym: "malignant tumor of the eye" EXACT [NCIT:C4767] +synonym: "neoplasm of eye" BROAD [DOID:2174] +synonym: "neoplasm of eye proper" RELATED [DOID:2174] +synonym: "ocular tumor" BROAD [DOID:2174, NCIT:C3030] +xref: DOID:2174 {source="MONDO:equivalentTo"} +xref: ICD9:190.8 {source="DOID:2174"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005134 {source="MONDO:equivalentTo", source="DOID:2174"} +xref: NCIT:C4767 {source="MONDO:equivalentTo"} +xref: SCTID:371486001 {source="MONDO:equivalentTo", source="DOID:2174"} +is_a: MONDO:0000649 {source="DOID:2174", source="MONDO:Entailed", source="MONDO:Redundant"} ! sensory system cancer +is_a: MONDO:0005627 ! head and neck cancer +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C4767"} ! eye neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch DOID:2174 +property_value: exactMatch http://identifiers.org/mesh/D005134 +property_value: exactMatch http://identifiers.org/snomedct/371486001 +property_value: exactMatch NCIT:C4767 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002238 +name: ascending colon cancer +def: "A malignant neoplasm involving the ascending colon." [https://orcid.org/0000-0002-6601-2165] +synonym: "ascending colon cancer" EXACT [MONDO:patterns/location] +synonym: "Ca ascending colon" EXACT [DOID:218] +synonym: "cancer of ascending colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant ascending colon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of ascending colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of right colon" EXACT [DOID:218] +synonym: "malignant tumor of ascending colon" EXACT [DOID:218] +xref: DOID:218 {source="MONDO:equivalentTo"} +xref: ICD9:153.6 {source="DOID:218", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363412000 {source="DOID:218", source="MONDO:equivalentTo"} +xref: UMLS:C0153439 {source="DOID:218", source="MONDO:equivalentTo"} +is_a: MONDO:0021063 {source="DOID:218", source="MONDO:Redundant"} ! malignant colon neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001156 ! ascending colon +relationship: disease_has_location UBERON:0001156 ! ascending colon +property_value: exactMatch DOID:218 +property_value: exactMatch http://identifiers.org/snomedct/363412000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153439 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002245 +name: blood platelet disease +def: "Disorders caused by abnormalities in platelet count or function." [MESH:D001791] +synonym: "platelet abnormality" EXACT [NCIT:C131634] +synonym: "platelet disorder" EXACT [MONDO:cjm, NCIT:C131634] +synonym: "thrombocytopathy" RELATED [] +xref: MESH:D001791 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: NCIT:C131634 {source="MONDO:equivalentTo"} +xref: SCTID:22716005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005570 {source="MESH:D001791"} ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of CL:0000233 ! platelet +relationship: disease_has_basis_in_dysfunction_of CL:0000233 ! platelet +property_value: exactMatch http://identifiers.org/mesh/D001791 +property_value: exactMatch http://identifiers.org/snomedct/22716005 +property_value: exactMatch NCIT:C131634 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0002251 +name: hepatitis +def: "An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders." [NCIT:P378] +synonym: "acute and subacute liver necrosis" NARROW [DOID:2237] +synonym: "acute hepatitis" NARROW [DOID:2237] +synonym: "acute/subac. necrosis of liver" NARROW [DOID:2237] +synonym: "animal hepatitis" NARROW [DOID:2237] +synonym: "chronic hepatitis" NARROW [DOID:2237] +synonym: "chronic persistent hepatitis" NARROW [DOID:2237] +synonym: "Hepatitides" RELATED [MESH:D006505] +synonym: "Hepatitis" EXACT [NCIT:C3095] +synonym: "hepatitis" EXACT [NCIT:C3095] +synonym: "inflammation of liver" EXACT [] +synonym: "liver inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2237 {source="MONDO:equivalentTo"} +xref: EFO:0008496 {source="MONDO:equivalentTo"} +xref: ICD9:570 {source="DOID:2237", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:571.4 {source="DOID:2237"} +xref: ICD9:571.40 {source="DOID:2237"} +xref: ICD9:571.41 {source="DOID:2237"} +xref: MESH:D006505 {source="MONDO:equivalentTo"} +xref: NCIT:C3095 {source="MONDO:equivalentTo"} +xref: SCTID:197268000 {source="DOID:2237", source="MONDO:equivalentTo"} +is_a: MONDO:0005154 {source="DOID:2237", source="MESH:D006505", source="MONDO:Redundant", source="NCIT:C3095/inferred"} ! liver disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002107 ! liver +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +relationship: disease_has_inflammation_site UBERON:0002107 ! liver +property_value: exactMatch DOID:2237 +property_value: exactMatch http://identifiers.org/mesh/D006505 +property_value: exactMatch http://identifiers.org/snomedct/197268000 +property_value: exactMatch NCIT:C3095 +property_value: excluded_subClassOf NCBITaxon:10239 {source="MONDO:Wikidata"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002254 +name: syndromic disease +def: "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition." [NCIT:C28193] +subset: harrisons_view +synonym: "cluster, symptom" EXACT [MESH:D013577] +synonym: "clusters, symptom" EXACT [MESH:D013577] +synonym: "symptom cluster" EXACT [MESH:D013577] +synonym: "symptom clusters" EXACT [MESH:D013577] +synonym: "syndrome" EXACT [NCIT:C28193, OGMS:0000086] +synonym: "syndrome associated with disease or disorder" EXACT [MONDO:patterns/syndromic] +synonym: "syndromes" EXACT [MESH:D013577] +synonym: "syndromic disease" EXACT [MONDO:patterns/syndromic] +synonym: "syndromic disease or disorder" EXACT [MONDO:patterns/syndromic] +xref: DOID:225 {source="MONDO:equivalentTo"} +xref: MESH:D013577 {source="DOID:225", source="MONDO:equivalentTo"} +xref: NCIT:C28193 {source="DOID:225", source="MONDO:equivalentTo"} +xref: OGMS:0000086 {source="MONDO:cjm"} +xref: UMLS:C0039082 {source="DOID:225", source="MONDO:equivalentTo", source="NCIT:C28193"} +is_a: MONDO:0000001 {source="DOID:225", source="MESH:D013577", source="MONDO:Redundant", source="NCIT:C28193"} ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: has_modifier MONDO:0021127 ! has a syndromic presentation +relationship: has_modifier MONDO:0021127 ! has a syndromic presentation +property_value: exactMatch DOID:225 +property_value: exactMatch http://identifiers.org/mesh/D013577 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039082 +property_value: exactMatch NCIT:C28193 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/syndromic.yaml + +[Term] +id: MONDO:0002256 +name: cervix disorder +def: "A non-neoplastic or neoplastic disorder that affects the cervix. Representative examples include cervicitis, endocervical polyp, and carcinoma." [NCIT:P378] +synonym: "cervical disorder" EXACT [NCIT:C40241] +synonym: "disease of uterine cervix" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of uterine cervix" EXACT [] +synonym: "disorder of uterine cervix" EXACT [MONDO:patterns/location_top] +synonym: "uterine cervix disease" EXACT [MONDO:patterns/location] +synonym: "uterine cervix disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:2253 {source="MONDO:equivalentTo"} +xref: MESH:D002577 {source="DOID:2253", source="MONDO:equivalentTo"} +xref: NCIT:C40241 {source="DOID:2253", source="MONDO:equivalentTo"} +xref: SCTID:63339007 {source="DOID:2253", source="MONDO:equivalentTo"} +xref: UMLS:C0007867 {source="DOID:2253", source="MONDO:equivalentTo"} +is_a: MONDO:0002654 {source="DOID:2253", source="MESH:D002577", source="MONDO:Redundant", source="NCIT:C40241"} ! uterine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +relationship: disease_has_location UBERON:0000002 ! uterine cervix +property_value: exactMatch DOID:2253 +property_value: exactMatch http://identifiers.org/mesh/D002577 +property_value: exactMatch http://identifiers.org/snomedct/63339007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007867 +property_value: exactMatch NCIT:C40241 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002258 +name: pharyngitis +def: "Inflammation of the throat most often caused by viral and bacterial infections. Other causes include allergens, chemical substances, and trauma." [NCIT:C26851] +synonym: "acute pharyngitis" NARROW [DOID:2275, ICD9CM:462] +synonym: "acute sore throat" NARROW [DOID:2275] +synonym: "chronic pharyn/nasopharyngitis" NARROW [DOID:2275] +synonym: "chronic pharyngitis" NARROW [DOID:2275, ICD9CM:472.1] +synonym: "chronic pharyngitis and nasopharyngitis" NARROW [DOID:2275] +synonym: "chronic sore throat" NARROW [DOID:2275] +synonym: "inflamed throat" EXACT [DOID:2275] +synonym: "inflammation of throat" EXACT [] +synonym: "persistent sore throat" NARROW [DOID:2275] +synonym: "pharyngeal disease" BROAD [DOID:2275] +synonym: "pharyngeal disorder" BROAD [DOID:2275] +synonym: "pharyngitis - acute" NARROW [DOID:2275] +synonym: "Sore throat" EXACT [NCIT:C26851] +synonym: "Sore throat - chronic" NARROW [DOID:2275] +synonym: "throat inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2275 {source="MONDO:equivalentTo"} +xref: ICD9:462 {source="DOID:2275"} +xref: ICD9:472 {source="DOID:2275"} +xref: ICD9:478.20 {source="DOID:2275"} +xref: MESH:D010612 {source="DOID:2275", source="MONDO:equivalentTo"} +xref: NCIT:C26851 {source="DOID:2275", source="MONDO:equivalentTo"} +xref: SCTID:405737000 {source="DOID:2275", source="MONDO:equivalentTo"} +xref: UMLS:C0031350 {source="DOID:2275", source="MONDO:equivalentTo", source="NCIT:C26851"} +is_a: MONDO:0004867 {source="DOID:2275"} ! upper respiratory tract disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000341 ! throat +relationship: disease_has_inflammation_site UBERON:0000341 ! throat +property_value: exactMatch DOID:2275 +property_value: exactMatch http://identifiers.org/mesh/D010612 +property_value: exactMatch http://identifiers.org/snomedct/405737000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031350 +property_value: exactMatch NCIT:C26851 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002259 +name: gonadal disorder +def: "A non-neoplastic or neoplastic disorder that affects the testis or the ovary." [NCIT:P378] +synonym: "disease of gonad" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of gonad" EXACT [] +synonym: "disorder of gonad" EXACT [MONDO:patterns/location_top] +synonym: "disorder of gonads" EXACT [NCIT:C26786] +synonym: "gonad disease" EXACT [MONDO:patterns/location] +synonym: "gonad disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "gonadal disorder" EXACT [NCIT:C26786] +synonym: "gonadal disorders" EXACT [NCIT:C26786] +xref: DOID:2277 {source="MONDO:equivalentTo"} +xref: MESH:D006058 {source="DOID:2277", source="MONDO:equivalentTo"} +xref: NCIT:C26786 {source="DOID:2277", source="MONDO:equivalentTo"} +xref: UMLS:C0018050 {source="DOID:2277", source="MONDO:equivalentTo"} +is_a: MONDO:0005039 ! reproductive system disorder +is_a: MONDO:0005151 {source="DOID:2277", source="MESH:D006058"} ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000991 ! gonad +relationship: disease_has_location UBERON:0000991 ! gonad +property_value: exactMatch DOID:2277 +property_value: exactMatch http://identifiers.org/mesh/D006058 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018050 +property_value: exactMatch NCIT:C26786 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002260 +name: hidradenitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the apocrine sweat gland." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "apocrine sweat gland" EXACT [NCIT:C32132] +synonym: "apocrine sweat gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "Hydradenitis" EXACT [DOID:2282] +synonym: "inflammation of apocrine sweat gland" EXACT [] +xref: DOID:2282 {source="MONDO:equivalentTo"} +xref: ICD9:705.83 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2282"} +xref: MESH:D016575 {source="MONDO:equivalentTo", source="DOID:2282"} +xref: NCIT:C112190 {source="MONDO:otherHierarchy", source="DOID:2282"} +xref: NCIT:C32132 {source="MONDO:equivalentTo"} +xref: SCTID:69741000 {source="MONDO:equivalentTo", source="DOID:2282"} +xref: UMLS:C0085160 {source="MONDO:equivalentTo", source="DOID:2282"} +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0024467 ! apocrine sweat gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000382 ! apocrine sweat gland +relationship: disease_has_inflammation_site UBERON:0000382 ! apocrine sweat gland +property_value: exactMatch DOID:2282 +property_value: exactMatch http://identifiers.org/mesh/D016575 +property_value: exactMatch http://identifiers.org/snomedct/69741000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085160 +property_value: exactMatch NCIT:C32132 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: relatedMatch NCIT:C112190 + +[Term] +id: MONDO:0002263 +name: female reproductive system disorder +def: "A disease involving the female reproductive system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of female genital system" RELATED [] +synonym: "disease of female reproductive system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of female reproductive system" EXACT [] +synonym: "disorder of female genital system" EXACT [] +synonym: "disorder of female genital tract" RELATED [] +synonym: "disorder of female reproductive system" EXACT [MONDO:patterns/location_top] +synonym: "female reproductive disease" EXACT [DOID:229] +synonym: "female reproductive system disease" EXACT [MONDO:patterns/location, NCIT:C27020] +synonym: "female reproductive system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "female reproductive system disorder" EXACT [NCIT:C27020] +synonym: "gynecological disease" RELATED [] +xref: DOID:229 {source="MONDO:equivalentTo"} +xref: ICD9:629.9 {source="DOID:229"} +xref: MESH:D005831 {source="DOID:229", source="MONDO:equivalentTo"} +xref: NCIT:C27020 {source="MONDO:equivalentTo"} +xref: SCTID:310789003 {source="DOID:229", source="MONDO:equivalentTo"} +is_a: MONDO:0005039 {source="DOID:229", source="MONDO:Redundant", source="NCIT:C27020"} ! reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000474 ! female reproductive system +relationship: disease_has_location UBERON:0000474 ! female reproductive system +property_value: exactMatch DOID:229 +property_value: exactMatch http://identifiers.org/mesh/D005831 +property_value: exactMatch http://identifiers.org/snomedct/310789003 +property_value: exactMatch NCIT:C27020 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002267 +name: obstructive lung disease +def: "Any disorder marked by obstruction of conducting airways of the lung. airway obstruction may be acute, chronic, intermittent, or persistent." [MESH:D008173] +synonym: "respiratory airway obstruction" EXACT [DOID:2320] +xref: DOID:2320 {source="MONDO:equivalentTo"} +xref: MESH:D008173 {source="DOID:2320", source="MONDO:equivalentTo"} +xref: UMLS:C0600260 {source="DOID:2320", source="MONDO:equivalentTo"} +is_a: MONDO:0005275 {source="DOID:2320", source="MESH:D008173"} ! lung disorder +property_value: exactMatch DOID:2320 +property_value: exactMatch http://identifiers.org/mesh/D008173 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0600260 + +[Term] +id: MONDO:0002269 +name: gastroenteritis +def: "An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting." [NCIT:C34632] +synonym: "cholera morbus" EXACT [DOID:2326] +synonym: "infectious colitis, enteritis and gastroenteritis" NARROW [DOID:2326] +synonym: "inflammation of intestine" EXACT [] +synonym: "intestine inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2326 {source="MONDO:equivalentTo"} +xref: EFO:1001463 {source="MONDO:equivalentTo"} +xref: ICD9:558.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005759 {source="MONDO:equivalentTo", source="DOID:2326"} +xref: NCIT:C34632 {source="MONDO:equivalentTo", source="DOID:2326"} +xref: SCTID:25374005 {source="MONDO:equivalentTo", source="DOID:2326"} +xref: UMLS:C0017160 {source="MONDO:equivalentTo", source="DOID:2326", source="NCIT:C34632"} +is_a: MONDO:0005020 {source="MONDO:Redundant"} ! intestinal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C34632/inferred"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000160 ! intestine +relationship: disease_has_feature HP:0002013 {source="MONDO:Wikidata"} ! Vomiting +relationship: disease_has_feature MONDO:0001517 {source="MONDO:Wikidata"} ! dysentery +relationship: disease_has_inflammation_site UBERON:0000160 ! intestine +property_value: exactMatch DOID:2326 +property_value: exactMatch http://identifiers.org/mesh/D005759 +property_value: exactMatch http://identifiers.org/snomedct/25374005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017160 +property_value: exactMatch NCIT:C34632 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002270 +name: viral gastritis +def: "Inflammation of the stomach resulting from viral infection." [NCIT:C27184] +synonym: "viral gastritis" EXACT [NCIT:C27184] +synonym: "Viruses caused gastritis (disease)" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses gastritis (disease)" EXACT [] +xref: DOID:2327 {source="MONDO:equivalentTo"} +xref: ICD9:008.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27184 {source="MONDO:equivalentTo", source="DOID:2327"} +xref: SCTID:285344007 {source="MONDO:equivalentTo", source="DOID:2327"} +xref: UMLS:C0563238 {source="MONDO:equivalentTo", source="DOID:2327", source="NCIT:C27184"} +is_a: MONDO:0004966 {source="DOID:2327", source="MONDO:Redundant", source="NCIT:C27184"} ! gastritis +is_a: MONDO:0043424 ! digestive system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0000945 ! stomach +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch DOID:2327 +property_value: exactMatch http://identifiers.org/snomedct/285344007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0563238 +property_value: exactMatch NCIT:C27184 + +[Term] +id: MONDO:0002271 +name: colon adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the colon" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma - colon" EXACT [NCIT:C4349] +synonym: "adenocarcinoma of colon" EXACT [DOID:234, NCIT:C4349] +synonym: "adenocarcinoma of the colon" EXACT [DOID:234, NCIT:C4349] +synonym: "COAD" RELATED ABBREVIATION [ONCOTREE:COAD] +synonym: "colon adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C4349] +synonym: "colonic adenocarcinoma" EXACT [DOID:234, NCIT:C4349] +xref: DOID:234 {source="MONDO:equivalentTo"} +xref: EFO:1001949 {source="MONDO:equivalentTo"} +xref: NCIT:C4349 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:234"} +xref: ONCOTREE:COAD {source="MONDO:equivalentTo"} +xref: UMLS:C0338106 {source="MONDO:equivalentTo", source="NCIT:C4349", source="DOID:234"} +is_a: MONDO:0002032 {source="DOID:234", source="EFO:1001949", source="MONDO:Redundant", source="NCIT:C4349"} ! colon carcinoma +is_a: MONDO:0005008 {source="DOID:234", source="EFO:1001949", source="MONDO:Redundant", source="NCIT:C4349", source="ONCOTREE:COAD"} ! colorectal adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:234 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0338106 +property_value: exactMatch NCIT:C4349 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002277 +name: arteriosclerosis disorder +def: "A vascular disorder characterized by thickening and hardening of the walls of the arteries." [NCIT:C34398] +synonym: "arterial sclerosis" EXACT [NCIT:C34398] +synonym: "arteriosclerosis" EXACT [MONDO:ambiguous] +synonym: "arteriosclerotic cardiovascular disease" EXACT [DOID:2348, MONDO:0002276, NCIT:C34403] +synonym: "arteriosclerotic vascular disease" EXACT [] +synonym: "cardiovascular arteriosclerosis" EXACT [DOID:2348] +synonym: "vascular sclerosis" EXACT [NCIT:C34398] +xref: CSP:0571-2299 {source="DOID:2349"} +xref: DOID:2348 {source="MONDO:equivalentTo"} +xref: DOID:2349 {source="MONDO:equivalentTo"} +xref: EFO:0009086 {source="MONDO:equivalentTo"} +xref: HP:0002634 {source="MONDO:otherHierarchy"} +xref: ICD9:440 {source="DOID:2348"} +xref: MESH:D001161 {source="MONDO:equivalentTo", source="DOID:2349"} +xref: NCIT:C34398 {source="MONDO:equivalentTo", source="DOID:2349"} +xref: NCIT:C34403 {source="MONDO:equivalentTo", source="DOID:2348"} +xref: SCTID:72092001 {source="MONDO:equivalentTo", source="DOID:2349"} +xref: UMLS:C0003850 {source="MONDO:equivalentTo", source="NCIT:C34398", source="DOID:2349"} +xref: UMLS:C3665365 {source="MONDO:equivalentTo", source="DOID:2348", source="NCIT:C34403"} +is_a: MONDO:0000473 {source="DOID:2348/inferred", source="DOID:2349", source="NCIT:C34398"} ! arterial disorder +property_value: exactMatch DOID:2348 +property_value: exactMatch DOID:2349 +property_value: exactMatch http://identifiers.org/mesh/D001161 +property_value: exactMatch http://identifiers.org/snomedct/72092001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003850 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3665365 +property_value: exactMatch NCIT:C34398 +property_value: exactMatch NCIT:C34403 + +[Term] +id: MONDO:0002278 +name: benign colon neoplasm +alt_id: MONDO:0021466 +def: "A non-metastasizing neoplasm arising from the wall of the colon." [NCIT:C2894] +synonym: "benign colon neoplasm" EXACT [NCIT:C2894] +synonym: "benign colon tumor" EXACT [NCIT:C2894] +synonym: "benign colonic neoplasm" EXACT [NCIT:C2894] +synonym: "benign colonic tumor" EXACT [NCIT:C2894] +synonym: "benign neoplasm of colon" EXACT [NCIT:C2894] +synonym: "benign neoplasm of the colon" EXACT [NCIT:C2894] +synonym: "benign tumor of colon" EXACT [NCIT:C2894] +synonym: "benign tumor of the colon" EXACT [NCIT:C2894] +synonym: "colon benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "colon neoplasm" BROAD [DOID:235] +synonym: "colonic benign neoplasm" RELATED [DOID:235] +synonym: "colonic Mass" EXACT [DOID:235, NCIT:C37904] +synonym: "colonic tumor" BROAD [DOID:235, NCIT:C2953] +xref: DOID:235 {source="MONDO:equivalentTo"} +xref: ICD9:211.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C2894 {source="MONDO:equivalentTo"} +xref: SCTID:92065004 {source="MONDO:equivalentTo"} +xref: UMLS:C0004991 {source="MONDO:equivalentTo", source="NCIT:C2894"} +is_a: MONDO:0005401 {source="MONDO:Redundant", source="NCIT:C2894"} ! colonic neoplasm +is_a: MONDO:0021444 {source="MONDO:Redundant", source="NCIT:C2894"} ! benign neoplasm of large intestine +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:235 +property_value: exactMatch http://identifiers.org/snomedct/92065004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004991 +property_value: exactMatch NCIT:C2894 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0002280 +name: anemia +def: "A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability." [NCIT:C2869] +synonym: "anaemia" EXACT [DOID:2355] +synonym: "anemia" EXACT [MONDO:ambiguous, NCIT:C2869] +synonym: "anemia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:2355 {source="MONDO:equivalentTo"} +xref: EFO:0004272 {source="DOID:2355", source="MONDO:equivalentTo"} +xref: HP:0001903 {source="MONDO:otherHierarchy"} +xref: ICD9:285.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:285.9 {source="DOID:2355", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D000740 {source="DOID:2355", source="MONDO:equivalentTo"} +xref: NCIT:C2869 {source="DOID:2355", source="MONDO:equivalentTo"} +xref: SCTID:271737000 {source="DOID:2355", source="MONDO:equivalentTo"} +is_a: MONDO:0005570 {source="DOID:2355", source="MESH:D000740", source="NCIT:C2869/inferred"} ! hematologic disorder +relationship: disease_has_basis_in_disruption_of GO:0034101 ! erythrocyte homeostasis +property_value: exactMatch DOID:2355 +property_value: exactMatch http://identifiers.org/mesh/D000740 +property_value: exactMatch http://identifiers.org/snomedct/271737000 +property_value: exactMatch NCIT:C2869 +property_value: IAO:0000589 "anemia (disease)" xsd:string + +[Term] +id: MONDO:0002285 +name: pupil disorder +def: "A disease involving the pupil." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of pupil" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pupil" EXACT [] +synonym: "disorder of pupil" EXACT [MONDO:patterns/location_top] +synonym: "pupil disease" EXACT [MONDO:patterns/location] +synonym: "pupil disease or disorder" EXACT [MONDO:patterns/location] +synonym: "pupillary disorder" EXACT [DOID:238] +xref: DOID:238 {source="MONDO:equivalentTo"} +xref: SCTID:68633000 {source="DOID:238", source="MONDO:equivalentTo"} +xref: UMLS:C0034124 {source="DOID:238", source="MONDO:equivalentTo"} +is_a: MONDO:0002289 ! iris disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001771 ! pupil +relationship: disease_has_location UBERON:0001771 ! pupil +property_value: exactMatch DOID:238 +property_value: exactMatch http://identifiers.org/snomedct/68633000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034124 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002286 +name: renal artery disease +def: "A disease involving the renal artery." [https://orcid.org/0000-0002-6601-2165] +synonym: "renal vascular disease" EXACT [DOID:2388] +synonym: "vascular disorder of kidney" EXACT [DOID:2388, ICD9CM:593.81] +xref: DOID:2388 {source="MONDO:equivalentTo"} +xref: ICD9:593.81 {source="DOID:2388", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C101254 {source="MONDO:equivalentTo"} +xref: SCTID:16934004 {source="DOID:2388", source="MONDO:equivalentTo"} +xref: UMLS:C0268790 {source="DOID:2388", source="MONDO:equivalentTo"} +xref: UMLS:C3640053 {source="MONDO:equivalentTo", source="NCIT:C101254"} +is_a: MONDO:0005240 {source="DOID:2388", source="MONDO:Redundant"} ! kidney disorder +is_a: MONDO:0005561 ! aortic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001184 ! renal artery +intersection_of: disease_has_location UBERON:0002113 ! kidney +relationship: disease_has_location UBERON:0001184 ! renal artery +property_value: exactMatch DOID:2388 +property_value: exactMatch http://identifiers.org/snomedct/16934004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268790 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3640053 +property_value: exactMatch NCIT:C101254 + +[Term] +id: MONDO:0002289 +name: iris disorder +def: "A disease involving the iris." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of iris" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of iris" EXACT [] +synonym: "disorder of iris" EXACT [MONDO:patterns/location_top] +synonym: "iris disease" EXACT [MONDO:patterns/location] +synonym: "iris disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "iris disorder" EXACT [NCIT:C34737] +xref: DOID:240 {source="MONDO:equivalentTo"} +xref: MESH:D007499 {source="MONDO:equivalentTo", source="DOID:240"} +xref: NCIT:C34737 {source="MONDO:equivalentTo", source="DOID:240"} +xref: SCTID:85478004 {source="MONDO:equivalentTo", source="DOID:240"} +xref: UMLS:C0022078 {source="MONDO:equivalentTo", source="DOID:240"} +is_a: MONDO:0002661 {source="DOID:240", source="MESH:D007499", source="MONDO:Redundant", source="NCIT:C34737"} ! uveal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001769 ! iris +relationship: disease_has_location UBERON:0001769 ! iris +property_value: exactMatch DOID:240 +property_value: exactMatch http://identifiers.org/mesh/D007499 +property_value: exactMatch http://identifiers.org/snomedct/85478004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022078 +property_value: exactMatch NCIT:C34737 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002290 +name: clitoris cancer +def: "A malignant neoplasm that affects the clitoris." [NCIT:C3557] +synonym: "cancer of clitoris" EXACT [MONDO:patterns/cancer] +synonym: "carcinoma of clitoris" NARROW [DOID:2401, NCIT:C9362] +synonym: "clitoral Ca" EXACT [DOID:2401, SCTID:93758009] +synonym: "clitoris cancer" EXACT [MONDO:patterns/location] +synonym: "malignant clitoral neoplasm" EXACT [NCIT:C3557] +synonym: "malignant clitoral tumor" EXACT [NCIT:C3557] +synonym: "malignant clitoris neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3557] +synonym: "malignant clitoris tumor" EXACT [NCIT:C3557] +synonym: "malignant neoplasm of clitoris" EXACT [MONDO:patterns/cancer, NCIT:C3557] +synonym: "malignant neoplasm of the clitoris" EXACT [NCIT:C3557] +synonym: "malignant tumor of clitoris" EXACT [DOID:2401, NCIT:C3557] +synonym: "malignant tumor of the clitoris" EXACT [NCIT:C3557] +xref: DOID:2401 {source="MONDO:equivalentTo"} +xref: ICD9:184.3 {source="MONDO:equivalentTo", source="DOID:2401", source="MONDO:i2s"} +xref: NCIT:C3557 {source="MONDO:equivalentTo", source="DOID:2401"} +xref: SCTID:371979001 {source="MONDO:equivalentTo", source="DOID:2401"} +xref: UMLS:C0153589 {source="MONDO:equivalentTo", source="DOID:2401", source="NCIT:C3557"} +is_a: MONDO:0001528 {source="DOID:2401", source="MONDO:Redundant", source="NCIT:C3557"} ! vulva cancer +is_a: MONDO:0024877 ! clitoris neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002411 ! clitoris +property_value: exactMatch DOID:2401 +property_value: exactMatch http://identifiers.org/snomedct/371979001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153589 +property_value: exactMatch NCIT:C3557 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002297 +name: epidermal appendage tumor +def: "A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands." [NCIT:P378] +synonym: "adnexal neoplasm of skin" EXACT [NCIT:C4463] +synonym: "adnexal neoplasm of the skin" EXACT [NCIT:C4463] +synonym: "adnexal tumor of skin" EXACT [NCIT:C4463] +synonym: "adnexal tumor of the skin" EXACT [NCIT:C4463] +synonym: "cutaneous adnexal neoplasm" EXACT [NCIT:C4463] +synonym: "cutaneous appendage neoplasm" EXACT [] +synonym: "cutaneous appendage neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "cutaneous appendage tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "Epidermal appendage neoplasm" EXACT [NCIT:C4463] +synonym: "Epidermal appendage tumor" EXACT [NCIT:C4463] +synonym: "neoplasm of cutaneous appendage" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of Epidermal appendage" EXACT [NCIT:C4463] +synonym: "neoplasm of skin appendage" EXACT [NCIT:C4463] +synonym: "neoplasm of skin with adnexal differentiation" EXACT [DOID:2433] +synonym: "neoplasm of the skin appendage" EXACT [DOID:2433, NCIT:C4463] +synonym: "skin appendage neoplasm" EXACT [NCIT:C4463] +synonym: "skin appendage tumor" EXACT [NCIT:C4463] +synonym: "skin appendage tumour" EXACT [DOID:2433] +synonym: "tumor of cutaneous appendage" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of Epidermal appendage" EXACT [NCIT:C4463] +synonym: "tumor of skin appendage" EXACT [NCIT:C4463] +synonym: "tumor of the skin appendage" EXACT [NCIT:C4463] +xref: DOID:2433 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4463 {source="DOID:2433", source="MONDO:equivalentTo"} +xref: SCTID:126489007 {source="DOID:2433", source="MONDO:equivalentTo"} +xref: UMLS:C0345988 {source="DOID:2433", source="NCIT:C4463", source="MONDO:equivalentTo"} +is_a: MONDO:0002531 {source="DOID:2433", source="NCIT:C4463"} ! skin neoplasm +is_a: MONDO:0024481 ! skin appendage disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000021 ! cutaneous appendage +property_value: exactMatch DOID:2433 +property_value: exactMatch http://identifiers.org/snomedct/126489007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345988 +property_value: exactMatch NCIT:C4463 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002300 +name: dermis tumor +def: "A benign, intermediate, or malignant neoplasm that arises from the dermis." [NCIT:P378] +synonym: "dermal neoplasm" EXACT [NCIT:C4475] +synonym: "dermal tumor" EXACT [NCIT:C4475] +synonym: "dermis neoplasm" EXACT [] +synonym: "dermis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "dermis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of dermis" EXACT [DOID:2438, MONDO:patterns/neoplasm, NCIT:C4475] +synonym: "neoplasm of the dermis" EXACT [NCIT:C4475] +synonym: "tumor of dermis" EXACT [DOID:2438, MONDO:patterns/neoplasm, NCIT:C4475] +synonym: "tumor of the dermis" EXACT [NCIT:C4475] +xref: DOID:2438 {source="MONDO:equivalentTo"} +xref: NCIT:C4475 {source="MONDO:equivalentTo", source="DOID:2438"} +xref: UMLS:C0346041 {source="MONDO:equivalentTo", source="NCIT:C4475", source="DOID:2438"} +is_a: MONDO:0002531 {source="DOID:2438", source="NCIT:C4475"} ! skin neoplasm +is_a: MONDO:0021154 ! dermis disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002067 ! dermis +property_value: exactMatch DOID:2438 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346041 +property_value: exactMatch NCIT:C4475 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002301 +name: frontal sinus squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal epithelial surface of the frontal sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis." [NCIT:P378] +synonym: "epidermoid carcinoma of frontal sinus" EXACT [NCIT:C6067] +synonym: "epidermoid carcinoma of the frontal sinus" EXACT [DOID:2441, NCIT:C6067] +synonym: "frontal sinus epidermoid carcinoma" EXACT [NCIT:C6067] +synonym: "frontal sinus squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of frontal sinus" EXACT [NCIT:C6067] +synonym: "squamous cell carcinoma of the frontal sinus" EXACT [NCIT:C6067] +xref: DOID:2441 {source="MONDO:equivalentTo"} +xref: NCIT:C6067 {source="DOID:2441", source="MONDO:equivalentTo"} +xref: SCTID:707356001 {source="MONDO:equivalentTo"} +xref: UMLS:C1333646 {source="NCIT:C6067", source="DOID:2441", source="MONDO:equivalentTo"} +is_a: MONDO:0001756 {source="DOID:2441", source="MONDO:Redundant", source="NCIT:C6067"} ! frontal sinus cancer +is_a: MONDO:0044705 ! paranasal sinus squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001760 ! frontal sinus +property_value: exactMatch DOID:2441 +property_value: exactMatch http://identifiers.org/snomedct/707356001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333646 +property_value: exactMatch NCIT:C6067 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002307 +name: blepharoconjunctivitis +def: "Inflammation of both the eyelids and the conjunctiva." [NCIT:P378] +xref: DOID:2456 {source="MONDO:equivalentTo"} +xref: ICD10CM:H10.5 {source="MONDO:equivalentTo", source="DOID:2456"} +xref: ICD9:372.2 {source="DOID:2456"} +xref: ICD9:372.20 {source="MONDO:equivalentTo", source="DOID:2456", source="MONDO:i2s"} +xref: NCIT:C34430 {source="MONDO:equivalentTo", source="DOID:2456"} +xref: SCTID:68659002 {source="MONDO:equivalentTo", source="DOID:2456"} +xref: UMLS:C0005743 {source="MONDO:equivalentTo", source="DOID:2456", source="NCIT:C34430"} +is_a: MONDO:0003799 {source="MONDO:Redundant"} ! conjunctivitis +is_a: MONDO:0004785 {source="DOID:2456", source="MONDO:Redundant"} ! blepharitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001711 ! eyelid +intersection_of: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:2456 +property_value: exactMatch http://identifiers.org/snomedct/68659002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005743 +property_value: exactMatch https://icd.codes/icd10cm/H10.5 +property_value: exactMatch NCIT:C34430 + +[Term] +id: MONDO:0002311 +name: retinal vascular disorder +def: "Retinal damage resulting from diminished blood flow/oxygenation due to abnormalities of the retinal vessels. Causes include hypertension, diabetes, thrombosis, embolism, and hemorrhage." [NCIT:C35170] +synonym: "retina circulation disorder" EXACT [DOID:2462] +synonym: "retinal vascular disorder" EXACT [NCIT:C35170] +xref: DOID:2462 {source="MONDO:equivalentTo"} +xref: ICD9:362.13 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35170 {source="DOID:2462", source="MONDO:equivalentTo"} +xref: SCTID:57534004 {source="DOID:2462", source="MONDO:equivalentTo"} +xref: UMLS:C0154833 {source="DOID:2462", source="MONDO:equivalentTo", source="NCIT:C35170"} +is_a: MONDO:0005283 {source="DOID:2462", source="MONDO:Redundant"} ! retinal disorder +is_a: MONDO:0005552 ! ocular vascular disorder +is_a: MONDO:0020676 {source="MONDO:cjm"} ! disorder of central nervous system or retinal vasculature +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0005385 ! vascular disorder +intersection_of: disease_has_location UBERON:0004864 ! vasculature of retina +relationship: disease_has_location UBERON:0004864 ! vasculature of retina +property_value: exactMatch DOID:2462 +property_value: exactMatch http://identifiers.org/snomedct/57534004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154833 +property_value: exactMatch NCIT:C35170 + +[Term] +id: MONDO:0002314 +name: chronic conjunctivitis +def: "Conjunctivitis that is persistent and long-standing." [NCIT:P378] +synonym: "chronic conjunctivitis" EXACT [DOID:2475, NCIT:C35197] +synonym: "chronic conjunctivitis (disease)" EXACT [] +synonym: "chronic conjunctivitis, unspecified" EXACT [DOID:2475, ICD9CM:372.10] +synonym: "conjunctivitis (disease), chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:2475 {source="MONDO:equivalentTo"} +xref: ICD10CM:H10.4 {source="DOID:2475", source="MONDO:equivalentTo"} +xref: ICD9:372.1 {source="DOID:2475"} +xref: ICD9:372.10 {source="DOID:2475", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35197 {source="DOID:2475", source="MONDO:equivalentTo"} +xref: SCTID:73762008 {source="DOID:2475", source="MONDO:equivalentTo"} +xref: UMLS:C0155145 {source="DOID:2475", source="NCIT:C35197", source="MONDO:equivalentTo"} +is_a: MONDO:0003799 {source="DOID:2475", source="MONDO:Redundant", source="NCIT:C35197"} ! conjunctivitis +intersection_of: MONDO:0003799 ! conjunctivitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:2475 +property_value: exactMatch http://identifiers.org/snomedct/73762008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155145 +property_value: exactMatch https://icd.codes/icd10cm/H10.4 +property_value: exactMatch NCIT:C35197 + +[Term] +id: MONDO:0002319 +name: phosphorus metabolism disease +def: "A metabolic disorder that affects the phosphate homeostasis." [NCIT:C97095] +synonym: "disorder of phosphorus metabolism" EXACT [DOID:2485, ICD9CM:275.3] +synonym: "phosphorus disorder" EXACT [DOID:2485] +synonym: "phosphorus metabolic disorder" EXACT [NCIT:C97095] +synonym: "phosphorus metabolism disorder" EXACT [DOID:2485] +xref: DOID:2485 {source="MONDO:equivalentTo"} +xref: ICD10CM:E83.3 {source="MONDO:equivalentTo"} +xref: ICD9:275.3 {source="DOID:2485", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D010760 {source="DOID:2485", source="MONDO:equivalentTo"} +xref: NCIT:C97095 {source="DOID:2485", source="MONDO:equivalentTo"} +xref: SCTID:87049008 {source="DOID:2485", source="MONDO:equivalentTo"} +xref: UMLS:C0031707 {source="DOID:2485", source="NCIT:C97095", source="MONDO:equivalentTo"} +is_a: MONDO:0000226 {source="DOID:2485", source="ICD10CM:E83.3", source="MONDO:Redundant"} ! mineral metabolism disease +intersection_of: MONDO:0000226 ! mineral metabolism disease +intersection_of: disease_disrupts GO:0006793 ! phosphorus metabolic process +relationship: disease_disrupts GO:0006793 ! phosphorus metabolic process +property_value: exactMatch DOID:2485 +property_value: exactMatch http://identifiers.org/mesh/D010760 +property_value: exactMatch http://identifiers.org/snomedct/87049008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031707 +property_value: exactMatch https://icd.codes/icd10cm/E83.3 +property_value: exactMatch NCIT:C97095 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0002320 +name: congenital nervous system disorder +def: "An abnormality of the nervous system that is present at birth or detected in the neonatal period." [NCIT:C97172] +synonym: "congenital abnormality of the nervous system" EXACT [NCIT:C97172] +synonym: "congenital nervous system disorder" EXACT [NCIT:C97172] +synonym: "congenital neurologic anomaly" EXACT [DOID:2490] +xref: DOID:2490 {source="MONDO:equivalentTo"} +xref: ICD9:742 {source="DOID:2490"} +xref: NCIT:C97172 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001016 ! nervous system +intersection_of: has_modifier MONDO:0021140 ! congenital +relationship: has_modifier MONDO:0021140 ! congenital +property_value: exactMatch DOID:2490 +property_value: exactMatch NCIT:C97172 +property_value: excluded_subClassOf MONDO:0000839 {source="DOID:2490"} + +[Term] +id: MONDO:0002321 +name: sensory peripheral neuropathy +def: "Inflammation or degeneration of the sensory nerves." [NCIT:C3501] +synonym: "peripheral neuropathy of sensory nerve" EXACT [MONDO:design_pattern] +synonym: "peripheral sensory neuropathy" EXACT [DOID:2491, NCIT:C3501] +synonym: "sensory nerve peripheral neuropathy" EXACT [MONDO:patterns/location] +synonym: "sensory neuropathy" EXACT [DOID:2491] +xref: DOID:2491 {source="MONDO:equivalentTo"} +xref: ICD9:356.2 {source="DOID:2491"} +xref: ICD9:356.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3501 {source="MONDO:equivalentTo", source="DOID:2491"} +xref: SCTID:95662005 {source="MONDO:equivalentTo", source="DOID:2491"} +xref: UMLS:C0151313 {source="MONDO:equivalentTo", source="NCIT:C3501", source="DOID:2491"} +is_a: MONDO:0005244 {source="DOID:2491", source="MONDO:Redundant", source="NCIT:C3501", source="NCIT:C3501/inferred"} ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_location UBERON:0001027 ! sensory nerve +relationship: disease_has_location UBERON:0001027 ! sensory nerve +property_value: exactMatch DOID:2491 +property_value: exactMatch http://identifiers.org/snomedct/95662005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151313 +property_value: exactMatch NCIT:C3501 + +[Term] +id: MONDO:0002326 +name: alcohol-induced mental disorder +xref: DOID:251 {source="MONDO:equivalentTo"} +xref: ICD9:291.8 {source="DOID:251"} +xref: ICD9:291.89 {source="DOID:251"} +is_a: MONDO:0005084 ! mental disorder +intersection_of: MONDO:0005084 ! mental disorder +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +relationship: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:251 +property_value: excluded_subClassOf MONDO:0004630 {source="DOID:251"} + +[Term] +id: MONDO:0002329 +name: testicular disorder +def: "A non-neoplastic or neoplastic disorder affecting the testis. Representative examples include torsion, infarction, germ cell tumor, sex cord-stromal tumor, lymphoma, and leukemia." [NCIT:C26890] +synonym: "disease of testis" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of testis" EXACT [] +synonym: "disorder of testis" EXACT [DOID:2519, MONDO:patterns/location_top] +synonym: "testicular disease" EXACT [NCIT:C26890] +synonym: "testicular disorder" EXACT [NCIT:C26890] +synonym: "testis disease" EXACT [MONDO:patterns/location] +synonym: "testis disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "testis disorder" EXACT [DOID:2519] +xref: DOID:2519 {source="MONDO:equivalentTo"} +xref: ICD9:608.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D013733 {source="MONDO:equivalentTo", source="DOID:2519"} +xref: NCIT:C26890 {source="NCIT:C26890", source="MONDO:equivalentTo", source="DOID:2519"} +xref: SCTID:64910008 {source="MONDO:equivalentTo", source="DOID:2519"} +xref: UMLS:C0039584 {source="NCIT:C26890", source="MONDO:equivalentTo", source="DOID:2519"} +is_a: MONDO:0002259 {source="DOID:2519", source="MESH:D013733", source="MONDO:Redundant"} ! gonadal disorder +is_a: MONDO:0003150 {source="DOID:2519", source="MESH:D013733", source="MONDO:Redundant", source="NCIT:C26890"} ! male reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000473 ! testis +relationship: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:2519 +property_value: exactMatch http://identifiers.org/mesh/D013733 +property_value: exactMatch http://identifiers.org/snomedct/64910008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039584 +property_value: exactMatch NCIT:C26890 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002330 +name: alcoholic psychosis +def: "A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol." [MESH:D011604] +synonym: "alcoholic psychoses" EXACT [DOID:252] +xref: DOID:252 {source="MONDO:equivalentTo"} +xref: EFO:1001260 {source="MONDO:equivalentTo"} +xref: ICD9:291.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:291.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:291.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:252"} +xref: MESH:D011604 {source="MONDO:equivalentTo", source="DOID:252"} +xref: SCTID:42344001 {source="MONDO:equivalentTo", source="DOID:252"} +is_a: MONDO:0002326 {source="DOID:252", source="MONDO:Redundant"} ! alcohol-induced mental disorder +is_a: MONDO:0005485 ! psychotic disorder +is_a: MONDO:0021698 {source="MESH:D011604", source="MESH:D011604/inferred"} ! alcohol-related disorders +intersection_of: MONDO:0005485 ! psychotic disorder +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:252 +property_value: exactMatch http://identifiers.org/mesh/D011604 +property_value: exactMatch http://identifiers.org/snomedct/42344001 + +[Term] +id: MONDO:0002332 +name: splenic disorder +def: "A disease involving the spleen." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of spleen" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of spleen" EXACT [] +synonym: "disorder of spleen" EXACT [MONDO:patterns/location_top] +synonym: "Dyssplenism" EXACT [DOID:2529] +synonym: "spleen disease" EXACT [DOID:2529, MONDO:patterns/location] +synonym: "spleen disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "spleen disorder" EXACT [NCIT:C35823] +synonym: "splenic disease" EXACT [] +synonym: "splenic disorder" EXACT [] +xref: DOID:2529 {source="MONDO:equivalentTo"} +xref: EFO:0009002 {source="MONDO:equivalentTo"} +xref: ICD10CM:D73 {source="MONDO:equivalentTo", source="DOID:2529"} +xref: ICD9:289.50 {source="DOID:2529"} +xref: MESH:D013158 {source="MONDO:equivalentTo", source="DOID:2529"} +xref: NCIT:C35823 {source="MONDO:equivalentTo", source="DOID:2529"} +xref: SCTID:51244008 {source="MONDO:equivalentTo", source="DOID:2529"} +xref: UMLS:C0037997 {source="MONDO:equivalentTo", source="DOID:2529"} +is_a: MONDO:0005570 ! hematologic disorder +is_a: MONDO:0005833 {source="DOID:2529", source="EFO:0009002", source="MESH:D013158"} ! lymphatic system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002106 ! spleen +relationship: disease_has_location UBERON:0002106 ! spleen +property_value: exactMatch DOID:2529 +property_value: exactMatch http://identifiers.org/mesh/D013158 +property_value: exactMatch http://identifiers.org/snomedct/51244008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037997 +property_value: exactMatch https://icd.codes/icd10cm/D73 +property_value: exactMatch NCIT:C35823 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002334 +name: hematopoietic and lymphoid system neoplasm +def: "Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003" [NCIT:C35813] +synonym: "blood cancer" NARROW [DOID:2531] +synonym: "blood neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "blood tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "hematologic cancer" RELATED [DOID:2531] +synonym: "hematologic malignancy" NARROW [DOID:2531] +synonym: "hematologic neoplasm" BROAD [DOID:2531] +synonym: "hematological tumors" EXACT [DOID:2531, NCIT:C27134] +synonym: "hematopoietic and lymphoid system neoplasm" EXACT [NCIT:C35813] +synonym: "hematopoietic and lymphoid system tumor" EXACT [DOID:2531, NCIT:C35813] +synonym: "hematopoietic cancer" NARROW [DOID:2531] +synonym: "hematopoietic neoplasm" BROAD [DOID:2531] +synonym: "hematopoietic neoplasm (morphologic abnormality)" BROAD [DOID:2531] +synonym: "hematopoietic system neoplasm" EXACT [] +synonym: "hematopoietic system tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "hematopoietic tumors" EXACT [DOID:2531, NCIT:C27134] +synonym: "malignant hematopoietic neoplasm (morphologic abnormality)" NARROW [DOID:2531] +synonym: "neoplasm of blood" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of hematopoietic system" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of blood" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of hematopoietic system" EXACT [MONDO:patterns/neoplasm] +xref: DOID:2531 {source="MONDO:equivalentTo"} +xref: MESH:D019337 {source="DOID:2531", source="MONDO:equivalentTo"} +xref: NCIT:C35813 {source="MONDO:equivalentTo"} +xref: SCTID:129154003 {source="MONDO:equivalentTo"} +xref: UMLS:C0376544 {source="DOID:2531", source="MONDO:equivalentTo"} +xref: UMLS:C0376545 {source="MONDO:equivalentTo"} +xref: UMLS:C1512393 {source="MONDO:equivalentTo", source="NCIT:C35813"} +is_a: MONDO:0005070 {source="DOID:2531/inferred", source="MESH:D019337/inferred", source="MONDO:Redundant", source="NCIT:C35813/inferred"} ! neoplasm +is_a: MONDO:0005570 {source="MESH:D019337", source="MONDO:Redundant"} ! hematologic disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002390 ! hematopoietic system +property_value: exactMatch DOID:2531 +property_value: exactMatch http://identifiers.org/mesh/D019337 +property_value: exactMatch http://identifiers.org/snomedct/129154003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376544 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376545 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512393 +property_value: exactMatch NCIT:C35813 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002345 +name: cervicitis +def: "An acute or chronic inflammatory process that affects the cervix. Causes include sexually transmitted diseases and bacterial infections. Clinical manifestations include abnormal vaginal bleeding and vaginal discharge." [NCIT:P378] +synonym: "cervicitis" EXACT [MONDO:ambiguous] +synonym: "cervicitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:2568 {source="MONDO:equivalentTo"} +xref: HP:0030160 {source="MONDO:otherHierarchy"} +xref: ICD9:616.0 {source="DOID:2568"} +xref: MESH:D002575 {source="MONDO:equivalentTo", source="DOID:2568"} +xref: NCIT:C26716 {source="MONDO:equivalentTo", source="DOID:2568"} +xref: SCTID:37610005 {source="MONDO:equivalentTo", source="DOID:2568"} +is_a: MONDO:0002256 {source="DOID:2568", source="MESH:D002575", source="NCIT:C26716/inferred"} ! cervix disorder +property_value: exactMatch DOID:2568 +property_value: exactMatch http://identifiers.org/mesh/D002575 +property_value: exactMatch http://identifiers.org/snomedct/37610005 +property_value: exactMatch NCIT:C26716 +property_value: IAO:0000589 "cervicitis (disease)" xsd:string + +[Term] +id: MONDO:0002351 +name: glottis cancer +def: "A malignant neoplasm that affects the glottic area of the larynx. The vast majority of cases represent squamous cell carcinomas." [NCIT:C3544] +synonym: "Ca larynx - glottis" EXACT [DOID:2595] +synonym: "cancer of glottis" EXACT [MONDO:patterns/cancer] +synonym: "glottis cancer" EXACT [MONDO:patterns/location] +synonym: "malignant glottis neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3544] +synonym: "malignant glottis tumor" EXACT [NCIT:C3544] +synonym: "malignant neoplasm of glottis" EXACT [MONDO:patterns/cancer, NCIT:C3544] +synonym: "malignant neoplasm of the glottis" EXACT [NCIT:C3544] +synonym: "malignant tumor of glottis" EXACT [NCIT:C3544] +synonym: "malignant tumor of the glottis" EXACT [DOID:2595, NCIT:C3544] +xref: DOID:2595 {source="MONDO:equivalentTo"} +xref: ICD9:161.0 {source="DOID:2595", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3544 {source="DOID:2595", source="MONDO:equivalentTo"} +xref: SCTID:187841006 {source="DOID:2595", source="MONDO:equivalentTo"} +xref: UMLS:C0153483 {source="DOID:2595", source="MONDO:equivalentTo", source="NCIT:C3544"} +is_a: MONDO:0002352 {source="DOID:2595", source="MONDO:Redundant", source="NCIT:C3544"} ! larynx cancer +is_a: MONDO:0002353 {source="MONDO:Redundant", source="NCIT:C3544"} ! glottis neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002486 ! glottis +property_value: exactMatch DOID:2595 +property_value: exactMatch http://identifiers.org/snomedct/187841006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153483 +property_value: exactMatch NCIT:C3544 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002352 +name: larynx cancer +def: "A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas." [NCIT:C7484] +synonym: "cancer of larynx" EXACT [MONDO:patterns/cancer] +synonym: "larynx cancer" EXACT [MONDO:patterns/location] +synonym: "malignant laryngeal neoplasm" EXACT [NCIT:C7484] +synonym: "malignant laryngeal tumor" EXACT [NCIT:C7484] +synonym: "malignant larynx neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7484] +synonym: "malignant larynx tumor" EXACT [NCIT:C7484] +synonym: "malignant neoplasm of larynx" EXACT [MONDO:patterns/cancer, NCIT:C7484] +synonym: "malignant neoplasm of the larynx" EXACT [NCIT:C7484] +synonym: "malignant tumor of larynx" EXACT [NCIT:C7484] +synonym: "malignant tumor of the larynx" EXACT [NCIT:C7484] +xref: DOID:2596 {source="MONDO:equivalentTo"} +xref: EFO:1000354 {source="MONDO:equivalentTo"} +xref: ICD9:161 {source="DOID:2596"} +xref: ICD9:161.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:161.9 {source="DOID:2596", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7484 {source="DOID:2596", source="MONDO:equivalentTo"} +xref: SCTID:363429002 {source="DOID:2596", source="MONDO:equivalentTo"} +xref: UMLS:C0007107 {source="NCIT:C7484", source="DOID:2596", source="MONDO:equivalentTo"} +is_a: MONDO:0000376 {source="DOID:2596", source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0021071 {source="EFO:1000354", source="MONDO:Redundant", source="NCIT:C7484"} ! laryngeal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch DOID:2596 +property_value: exactMatch http://identifiers.org/snomedct/363429002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007107 +property_value: exactMatch NCIT:C7484 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002353 +name: glottis neoplasm +def: "A benign or malignant neoplasm that affects the glottic area of the larynx." [NCIT:C4425] +synonym: "glottis neoplasm" EXACT [NCIT:C4425] +synonym: "glottis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "glottis tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4425] +synonym: "neoplasm of glottis" EXACT [MONDO:patterns/neoplasm, NCIT:C4425] +synonym: "neoplasm of the glottis" EXACT [NCIT:C4425] +synonym: "tumor of glottis" EXACT [MONDO:patterns/neoplasm, NCIT:C4425] +synonym: "tumor of the glottis" EXACT [DOID:2597, NCIT:C4425] +xref: DOID:2597 {source="MONDO:equivalentTo"} +xref: NCIT:C4425 {source="DOID:2597", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126693009 {source="DOID:2597", source="MONDO:equivalentTo"} +xref: UMLS:C0345713 {source="DOID:2597", source="MONDO:equivalentTo", source="NCIT:C4425"} +is_a: MONDO:0021071 {source="MONDO:Redundant", source="NCIT:C4425"} ! laryngeal neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002486 ! glottis +relationship: disease_has_location UBERON:0002486 ! glottis +property_value: exactMatch DOID:2597 +property_value: exactMatch http://identifiers.org/snomedct/126693009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345713 +property_value: exactMatch NCIT:C4425 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002354 +name: benign laryngeal neoplasm +def: "A non-metastasizing neoplasm that arises from the larynx. Representative examples include squamous papilloma and hemangioma." [NCIT:C3601] +synonym: "benign laryngeal neoplasm" EXACT [NCIT:C3601] +synonym: "benign laryngeal tumor" EXACT [NCIT:C3601] +synonym: "benign larynx neoplasm" EXACT [NCIT:C3601] +synonym: "benign larynx tumor" EXACT [NCIT:C3601] +synonym: "benign neoplasm of larynx" EXACT [NCIT:C3601] +synonym: "benign neoplasm of the larynx" EXACT [NCIT:C3601] +synonym: "benign tumor of larynx" EXACT [NCIT:C3601] +synonym: "benign tumor of the larynx" EXACT [NCIT:C3601] +synonym: "laryngeal benign neoplasm" RELATED [DOID:2598] +synonym: "laryngeal neoplasm, benign" EXACT [NCIT:C3601] +synonym: "laryngeal tumor" BROAD [DOID:2598, NCIT:C3156] +synonym: "larynx benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "larynx neoplasm" BROAD [DOID:2598] +xref: DOID:2598 {source="MONDO:equivalentTo"} +xref: ICD9:212.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3601 {source="MONDO:equivalentTo"} +xref: SCTID:92175003 {source="MONDO:equivalentTo"} +xref: UMLS:C0153952 {source="MONDO:equivalentTo", source="NCIT:C3601"} +is_a: MONDO:0000382 {source="DOID:2598", source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0021071 {source="MONDO:Redundant", source="NCIT:C3601"} ! laryngeal neoplasm +intersection_of: MONDO:0005165 {source="NCIT:C3601"} ! benign neoplasm +intersection_of: disease_has_location UBERON:0001737 {source="NCIT:C3601"} ! larynx +property_value: exactMatch DOID:2598 +property_value: exactMatch http://identifiers.org/snomedct/92175003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153952 +property_value: exactMatch NCIT:C3601 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0002355 +name: glottis carcinoma +def: "A carcinoma that arises from epithelial cells of the glottis." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of glottis" BROAD [NCIT:C4923] +synonym: "cancer of the glottis" BROAD [NCIT:C4923] +synonym: "carcinoma of glottis" EXACT [MONDO:patterns/carcinoma, NCIT:C4923] +synonym: "carcinoma of the glottis" EXACT [NCIT:C4923] +synonym: "glottic carcinoma" EXACT [DOID:2599, NCIT:C4923] +synonym: "glottic throat cancer" BROAD [NCIT:C4923] +synonym: "glottis cancer" BROAD [NCIT:C4923] +synonym: "glottis carcinoma" EXACT [MONDO:patterns/location, NCIT:C4923] +xref: DOID:2599 {source="MONDO:equivalentTo"} +xref: NCIT:C4923 {source="MONDO:equivalentTo", source="DOID:2599"} +xref: SCTID:372103002 {source="MONDO:equivalentTo", source="DOID:2599"} +xref: UMLS:C0740083 {source="MONDO:equivalentTo", source="DOID:2599", source="NCIT:C4923"} +is_a: MONDO:0002351 {source="DOID:2599", source="MONDO:Redundant", source="NCIT:C4923"} ! glottis cancer +is_a: MONDO:0002358 {source="MONDO:Redundant", source="NCIT:C4923"} ! laryngeal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002486 ! glottis +property_value: exactMatch DOID:2599 +property_value: exactMatch http://identifiers.org/snomedct/372103002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0740083 +property_value: exactMatch NCIT:C4923 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002356 +name: pancreas disorder +def: "A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms." [NCIT:C26842] +synonym: "disease of pancreas" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pancreas" EXACT [] +synonym: "disease, pancreatic" RELATED [MESH:D010182] +synonym: "diseases, pancreatic" RELATED [MESH:D010182] +synonym: "disorder of pancreas" EXACT [MONDO:patterns/location_top] +synonym: "pancreas disease" EXACT [MONDO:patterns/location] +synonym: "pancreas disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "pancreatic disease" RELATED [MESH:D010182] +synonym: "pancreatic disorder" EXACT [NCIT:C26842] +xref: DOID:26 {source="MONDO:equivalentTo"} +xref: ICD9:577.8 {source="DOID:26"} +xref: ICD9:577.9 +xref: MESH:D010182 {source="MONDO:equivalentTo"} +xref: NCIT:C26842 {source="MONDO:equivalentTo"} +xref: SCTID:3855007 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 {source="NCIT:C26842"} ! digestive system disorder +is_a: MONDO:0005151 {source="DOID:26"} ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001264 ! pancreas +relationship: disease_has_location UBERON:0001264 ! pancreas +property_value: exactMatch DOID:26 +property_value: exactMatch http://identifiers.org/mesh/D010182 +property_value: exactMatch http://identifiers.org/snomedct/3855007 +property_value: exactMatch NCIT:C26842 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002358 +name: laryngeal carcinoma +def: "Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation." [NCIT:C4855] +synonym: "cancer of larynx" BROAD [DOID:2600, NCIT:C4855] +synonym: "cancer of the larynx" BROAD [NCIT:C4855] +synonym: "carcinoma of larynx" EXACT [MONDO:patterns/carcinoma, NCIT:C4855] +synonym: "carcinoma of the larynx" EXACT [NCIT:C4855] +synonym: "laryngeal cancer" BROAD [NCIT:C4855] +synonym: "laryngeal carcinoma" EXACT [NCIT:C4855] +synonym: "laryngeal throat cancer" BROAD [NCIT:C4855] +synonym: "larynx carcinoma" EXACT [MONDO:patterns/location, NCIT:C4855] +xref: DOID:2600 {source="MONDO:equivalentTo"} +xref: GARD:0006862 {source="MONDO:equivalentTo"} +xref: NCIT:C4855 {source="DOID:2600", source="MONDO:equivalentTo"} +xref: SCTID:276975007 {source="DOID:2600", source="MONDO:equivalentTo"} +xref: UMLS:C0595989 {source="DOID:2600", source="MONDO:equivalentTo", source="NCIT:C4855"} +is_a: MONDO:0002352 {source="DOID:2600", source="MONDO:Redundant", source="NCIT:C4855"} ! larynx cancer +is_a: MONDO:0004993 {source="MONDO:Redundant", source="NCIT:C4855/inferred"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch DOID:2600 +property_value: exactMatch http://identifiers.org/snomedct/276975007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0595989 +property_value: exactMatch NCIT:C4855 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002361 +name: transverse colon cancer +def: "A malignant neoplasm involving the transverse colon." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca transverse colon" EXACT [DOID:261] +synonym: "cancer of transverse colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of transverse colon" EXACT [MONDO:patterns/cancer] +synonym: "malignant transverse colon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of transverse colon" EXACT [DOID:261] +synonym: "transverse colon cancer" EXACT [MONDO:patterns/location] +xref: DOID:261 {source="MONDO:equivalentTo"} +xref: ICD9:153.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:261"} +xref: SCTID:363408006 {source="MONDO:equivalentTo", source="DOID:261"} +xref: UMLS:C0153434 {source="MONDO:equivalentTo", source="DOID:261"} +is_a: MONDO:0021063 {source="DOID:261", source="MONDO:Redundant"} ! malignant colon neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001157 ! transverse colon +relationship: disease_has_location UBERON:0001157 ! transverse colon +property_value: exactMatch DOID:261 +property_value: exactMatch http://identifiers.org/snomedct/363408006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153434 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002363 +name: papilloma +def: "A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma." [NCIT:C7440] +synonym: "papilloma" EXACT [NCIT:C7440] +synonym: "papilloma (except papilloma of bladder M-81201) (morphologic abnormality)" EXACT [DOID:2615] +synonym: "papilloma, benign" EXACT [NCIT:C7440] +synonym: "papillomatosis NOS (morphologic abnormality)" RELATED [DOID:2615] +xref: DOID:2615 {source="MONDO:equivalentTo"} +xref: ICDO:8050/0 {source="NCIT:C7440"} +xref: MESH:D010212 {source="MONDO:equivalentTo", source="DOID:2615"} +xref: NCIT:C3713 {source="DOID:2615", source="MONDO:directSiblingOf"} +xref: NCIT:C7440 {source="MONDO:equivalentTo", source="DOID:2615"} +xref: SCTID:711329002 {source="MONDO:equivalentTo", source="DOID:2615"} +xref: UMLS:C0030354 {source="NCIT:C7440", source="MONDO:equivalentTo", source="DOID:2615"} +is_a: MONDO:0021096 {source="NCIT:C7440"} ! papillary epithelial neoplasm +is_a: MONDO:0036976 ! benign epithelial neoplasm +property_value: exactMatch DOID:2615 +property_value: exactMatch http://identifiers.org/mesh/D010212 +property_value: exactMatch http://identifiers.org/snomedct/711329002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030354 +property_value: exactMatch NCIT:C7440 + +[Term] +id: MONDO:0002366 +name: autonomic nervous system neoplasm +def: "Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system." [NCIT:C5112] +synonym: "autonomic nervous system neoplasm" EXACT [NCIT:C5112] +synonym: "autonomic nervous system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "autonomic nervous system neoplasms" EXACT [NCIT:C5112] +synonym: "autonomic nervous system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5112] +synonym: "neoplasm of autonomic nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C5112] +synonym: "neoplasm of the autonomic nervous system" EXACT [NCIT:C5112] +synonym: "tumor of autonomic nervous system" EXACT [DOID:2621, MONDO:patterns/neoplasm, NCIT:C5112] +synonym: "tumor of the autonomic nervous system" EXACT [NCIT:C5112] +xref: DOID:2621 {source="MONDO:equivalentTo"} +xref: NCIT:C5112 {source="MONDO:equivalentTo", source="DOID:2621", source="MONDO:exact-label-match"} +xref: UMLS:C1332356 {source="NCIT:C5112", source="MONDO:equivalentTo", source="DOID:2621"} +is_a: MONDO:0001292 ! autonomic nervous system disorder +is_a: MONDO:0001406 {source="DOID:2621", source="MONDO:Redundant", source="NCIT:C5112"} ! peripheral nervous system neoplasm +is_a: MONDO:0006130 ! central nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002410 ! autonomic nervous system +property_value: exactMatch DOID:2621 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332356 +property_value: exactMatch NCIT:C5112 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002367 +name: kidney cancer +def: "Primary or metastatic malignant neoplasm involving the kidney." [NCIT:C7548] +synonym: "cancer of kidney" EXACT [MONDO:patterns/cancer] +synonym: "kidney cancer" EXACT [MONDO:patterns/location] +synonym: "malignant kidney neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7548] +synonym: "malignant kidney tumor" EXACT [NCIT:C7548] +synonym: "malignant neoplasm of kidney" EXACT [MONDO:patterns/cancer, NCIT:C7548] +synonym: "malignant neoplasm of kidney except pelvis" EXACT [DOID:263] +synonym: "malignant neoplasm of the kidney" EXACT [NCIT:C7548] +synonym: "malignant renal neoplasm" EXACT [NCIT:C7548] +synonym: "malignant renal tumor" EXACT [NCIT:C7548] +synonym: "malignant tumor of kidney" EXACT [NCIT:C7548] +synonym: "malignant tumor of the kidney" EXACT [NCIT:C7548] +synonym: "malignant tumour of kidney" EXACT [DOID:263] +xref: DOID:263 {source="MONDO:equivalentTo"} +xref: ICD9:189.0 {source="DOID:263"} +xref: MESH:D007680 {source="MONDO:equivalentTo", source="DOID:263"} +xref: NCIT:C7548 {source="MONDO:equivalentTo", source="DOID:263"} +xref: SCTID:363518003 {source="MONDO:equivalentTo", source="DOID:263"} +xref: UMLS:CN881103 {source="MONDO:equivalentTo"} +is_a: MONDO:0006295 {source="DOID:263", source="MONDO:Redundant", source="NCIT:C7548"} ! malignant urinary system neoplasm +is_a: MONDO:0021163 {source="MONDO:Redundant", source="NCIT:C7548"} ! kidney neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch DOID:263 +property_value: exactMatch http://identifiers.org/mesh/D007680 +property_value: exactMatch http://identifiers.org/snomedct/363518003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN881103 +property_value: exactMatch NCIT:C7548 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002380 +name: myoepithelial tumor +def: "A benign or malignant tumor characterized by the presence of cells that show myoepithelial differentiation. Based on its morphologic features, it is classified as benign or malignant. A representative example of benign myoepithelioma is benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma or myoepithelial carcinoma are malignant breast myoepithelioma and salivary gland myoepithelial carcinoma." [NCIT:C40392] +synonym: "benign myoepithelioma" EXACT [DOID:2661, NCIT:C7442] +synonym: "myoepithelial adenoma" EXACT [DOID:2661] +synonym: "myoepithelial neoplasm" EXACT [DOID:2661, NCIT:C40392] +synonym: "myoepithelial tumor" EXACT [NCIT:C40392] +synonym: "myoepithelioma" EXACT [NCIT:C40392] +xref: DOID:2661 {source="MONDO:equivalentTo"} +xref: ICDO:8982/0 {source="NCIT:C40392"} +xref: ICDO:8982/1 {source="NCIT:C40392"} +xref: MESH:D009208 {source="DOID:2661", source="MONDO:equivalentTo"} +xref: NCIT:C40392 {source="DOID:2661", source="MONDO:equivalentTo"} +xref: UMLS:C0027070 {source="DOID:2661", source="MONDO:equivalentTo", source="NCIT:C40392"} +xref: UMLS:C1947949 {source="MONDO:equivalentTo"} +is_a: MONDO:0005626 ! epithelial neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000185 ! myoepithelial cell +relationship: disease_arises_from_structure CL:0000185 {source="NCIT:C40392"} ! myoepithelial cell +property_value: exactMatch DOID:2661 +property_value: exactMatch http://identifiers.org/mesh/D009208 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027070 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1947949 +property_value: exactMatch NCIT:C40392 + +[Term] +id: MONDO:0002381 +name: sweat gland neoplasm +alt_id: MONDO:0021219 +def: "A benign or malignant neoplasm arising from the sweat glands." [NCIT:C3398] +synonym: "neoplasm of sweat gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3398] +synonym: "neoplasm of the sweat gland" EXACT [NCIT:C3398] +synonym: "sweat gland neoplasm" EXACT [NCIT:C3398] +synonym: "sweat gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sweat gland neoplasms" EXACT [NCIT:C3398] +synonym: "sweat gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3398] +synonym: "sweat gland tumor (morphologic abnormality)" EXACT [DOID:2664] +synonym: "sweat gland tumor NOS (morphologic abnormality)" EXACT [DOID:2664] +synonym: "tumor of sweat gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3398] +synonym: "tumor of the sweat gland" EXACT [DOID:2664, NCIT:C3398] +xref: DOID:2664 {source="MONDO:equivalentTo"} +xref: EFO:1001204 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8400/1 {source="NCIT:C3398"} +xref: MESH:D013544 {source="DOID:2664", source="MONDO:equivalentTo"} +xref: NCIT:C3398 {source="DOID:2664", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126490003 {source="DOID:2664", source="MONDO:equivalentTo"} +xref: UMLS:C0038987 {source="DOID:2664", source="MONDO:equivalentTo", source="NCIT:C3398"} +is_a: MONDO:0002297 {source="NCIT:C3398"} ! epidermal appendage tumor +is_a: MONDO:0006615 {source="DOID:2664", source="MESH:D013544", source="MONDO:Redundant"} ! sweat gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001820 ! sweat gland +property_value: exactMatch DOID:2664 +property_value: exactMatch http://identifiers.org/mesh/D013544 +property_value: exactMatch http://identifiers.org/snomedct/126490003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038987 +property_value: exactMatch NCIT:C3398 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002405 +name: hepatic vascular disorder +def: "A non-neoplastic or neoplastic vascular disorder that affects the liver. Representative examples include veno-occlusive disease, hemangioma, lymphangioma, and angiosarcoma." [NCIT:P378] +synonym: "hepatic vascular disorder" EXACT [NCIT:C35442] +synonym: "liver vascular disorder" EXACT [NCIT:C35442] +synonym: "vascular disorder of liver" EXACT [DOID:272] +xref: DOID:272 {source="MONDO:equivalentTo"} +xref: ICD9:573.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C35442 {source="MONDO:equivalentTo", source="DOID:272"} +xref: SCTID:235878005 {source="MONDO:equivalentTo", source="DOID:272"} +xref: UMLS:C0400923 {source="MONDO:equivalentTo", source="NCIT:C35442", source="DOID:272"} +is_a: MONDO:0005154 {source="DOID:272", source="NCIT:C35442"} ! liver disorder +is_a: MONDO:0005385 {source="DOID:272", source="NCIT:C35442"} ! vascular disorder +intersection_of: MONDO:0005385 ! vascular disorder +intersection_of: disease_has_location UBERON:0006877 ! vasculature of liver +relationship: disease_has_location UBERON:0006877 ! vasculature of liver +property_value: exactMatch DOID:272 +property_value: exactMatch http://identifiers.org/snomedct/235878005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0400923 +property_value: exactMatch NCIT:C35442 + +[Term] +id: MONDO:0002406 +name: dermatitis +def: "An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis." [NCIT:C2983] +synonym: "inflammation of skin" EXACT [NCIT:C2983] +synonym: "inflammation of the skin" EXACT [NCIT:C2983] +synonym: "inflammation of zone of skin" EXACT [] +synonym: "inflammatory skin disease" EXACT [MONDO:0006501] +synonym: "skin inflammation" EXACT [DOID:2723] +synonym: "zone of skin inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2723 {source="MONDO:equivalentTo"} +xref: EFO:1000636 {source="MONDO:equivalentTo"} +xref: ICD9:692.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003872 {source="MONDO:equivalentTo", source="DOID:2723"} +xref: NCIT:C2983 {source="MONDO:equivalentTo", source="DOID:2723"} +xref: SCTID:43116000 {source="MONDO:equivalentTo", source="DOID:2723"} +xref: UMLS:C0011603 {source="MONDO:equivalentTo", source="DOID:2723", source="NCIT:C2983"} +is_a: MONDO:0005093 {source="DOID:2723", source="EFO:1000636", source="MESH:D003872", source="MONDO:Redundant", source="NCIT:C2983/inferred"} ! skin disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000014 ! zone of skin +relationship: disease_has_inflammation_site UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:2723 +property_value: exactMatch http://identifiers.org/mesh/D003872 +property_value: exactMatch http://identifiers.org/snomedct/43116000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011603 +property_value: exactMatch NCIT:C2983 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002409 +name: auditory system disorder +def: "A disease involving the auditory system." [https://orcid.org/0000-0002-6601-2165] +synonym: "auditory disease" EXACT [DOID:2742] +synonym: "auditory system disease" EXACT [MONDO:patterns/location] +synonym: "auditory system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of auditory system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of auditory system" EXACT [] +synonym: "disorder of auditory system" EXACT [MONDO:patterns/location_top] +synonym: "ear and mastoid disease" EXACT [DOID:2742] +xref: DOID:2742 {source="MONDO:equivalentTo"} +xref: EFO:1001455 {source="MONDO:equivalentTo"} +xref: ICD10CM:H60-H95 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:388.9 {source="MONDO:relatedTo", source="DOID:2742"} +xref: SCTID:362966006 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0016490 ! auditory system +relationship: disease_has_location UBERON:0016490 ! auditory system +property_value: exactMatch DOID:2742 +property_value: exactMatch http://identifiers.org/snomedct/362966006 +property_value: exactMatch https://icd.codes/icd10cm/H60-H95 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002412 +name: glycogen storage disease +def: "An inherited metabolic disorder characterized either by defects in glycogen synthesis or defects in the breaking down of glycogen. It results either in the creation of abnormal forms of glycogen or accumulation of glycogen in the tissues." [NCIT:C61272] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79201"} +synonym: "glycogen metabolism disorder" EXACT [DOID:0050728, DOID:2747] +synonym: "glycogen storage disease" EXACT [MONDO:0019244] +synonym: "glycogen storage disorder" EXACT [] +synonym: "glycogenoses" EXACT [DOID:2747, Wikipedia:Glycogen_storage_disease] +synonym: "glycogenosis" EXACT [DOID:2747, Orphanet:79201] +synonym: "GSD" EXACT ABBREVIATION [Orphanet:79201] +synonym: "inborn error of glycogen metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn glycogen metabolic process disorder" EXACT [] +synonym: "inborn glycogen storage disorder" EXACT [] +synonym: "rare inborn error of glycogen metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:0050728 {source="MONDO:equivalentTo"} +xref: DOID:2747 {source="MONDO:equivalentTo"} +xref: ICD10CM:E74.0 {source="Orphanet:79201/e", source="Orphanet:79201/specific", source="MONDO:equivalentTo", source="DOID:2747", source="Orphanet:79201"} +xref: ICD9:271.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2747"} +xref: MedDRA:10061990 {source="Orphanet:79201/e", source="Orphanet:79201"} +xref: MESH:D006008 {source="Orphanet:79201/e", source="MONDO:equivalentTo", source="DOID:2747", source="Orphanet:79201"} +xref: NCIT:C61272 {source="MONDO:equivalentTo", source="DOID:2747"} +xref: Orphanet:79201 {source="MONDO:equivalentTo"} +xref: SCTID:29633007 {source="MONDO:equivalentTo", source="DOID:2747"} +xref: UMLS:C0017919 {source="Orphanet:79201/e", source="MONDO:equivalentTo", source="NCIT:C61272", source="DOID:2747", source="Orphanet:79201"} +is_a: MONDO:0019214 {source="DOID:0050728", source="DOID:2747/inferred", source="MESH:D006008", source="MONDO:Redundant", source="Orphanet:79201"} ! inborn carbohydrate metabolic disorder +is_a: MONDO:0019243 ! inborn disorder of energy metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0005977 ! glycogen metabolic process +relationship: disease_has_basis_in_disruption_of GO:0005977 ! glycogen metabolic process +property_value: closeMatch http://identifiers.org/meddra/10061990 +property_value: exactMatch DOID:0050728 +property_value: exactMatch DOID:2747 +property_value: exactMatch http://identifiers.org/mesh/D006008 +property_value: exactMatch http://identifiers.org/snomedct/29633007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017919 +property_value: exactMatch https://icd.codes/icd10cm/E74.0 +property_value: exactMatch NCIT:C61272 +property_value: exactMatch Orphanet:79201 +property_value: excluded_subClassOf MONDO:0000422 {source="DOID:2747"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0002415 +name: bone carcinoma +def: "A carcinoma that involves the bone element." [MONDO:patterns/location] +synonym: "bone element carcinoma" EXACT [MONDO:patterns/location] +synonym: "carcinoma of bone element" EXACT [MONDO:patterns/carcinoma] +xref: DOID:2762 {source="MONDO:equivalentTo"} +is_a: MONDO:0002129 {source="DOID:2762", source="MONDO:Entailed", source="MONDO:Redundant"} ! bone cancer +is_a: MONDO:0004993 ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001474 ! bone element +relationship: disease_has_location UBERON:0001474 ! bone element +property_value: exactMatch DOID:2762 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002416 +name: ethmoid sinus squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal epithelial surface of the ethmoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis." [NCIT:P378] +synonym: "epidermoid carcinoma of ethmoid sinus" EXACT [NCIT:C6065] +synonym: "epidermoid carcinoma of ethmoidal sinus" EXACT [NCIT:C6065] +synonym: "epidermoid carcinoma of the ethmoid sinus" EXACT [NCIT:C6065] +synonym: "epidermoid carcinoma of the ethmoidal sinus" EXACT [DOID:2763, NCIT:C6065] +synonym: "ethmoid sinus epidermoid carcinoma" EXACT [NCIT:C6065] +synonym: "ethmoid sinus squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "ethmoidal sinus epidermoid carcinoma" EXACT [NCIT:C6065] +synonym: "ethmoidal sinus squamous cell carcinoma" EXACT [NCIT:C6065] +synonym: "squamous cell carcinoma of ethmoid sinus" EXACT [NCIT:C6065] +synonym: "squamous cell carcinoma of ethmoidal sinus" EXACT [NCIT:C6065] +synonym: "squamous cell carcinoma of the ethmoid sinus" EXACT [NCIT:C6065] +synonym: "squamous cell carcinoma of the ethmoidal sinus" EXACT [NCIT:C6065] +xref: DOID:2763 {source="MONDO:equivalentTo"} +xref: NCIT:C6065 {source="DOID:2763", source="MONDO:equivalentTo"} +xref: SCTID:707359008 {source="MONDO:equivalentTo"} +xref: UMLS:C1333477 {source="NCIT:C6065", source="DOID:2763", source="MONDO:equivalentTo"} +is_a: MONDO:0001763 {source="DOID:2763", source="MONDO:Redundant", source="NCIT:C6065"} ! ethmoid sinus cancer +is_a: MONDO:0044705 ! paranasal sinus squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002453 ! ethmoid sinus +property_value: exactMatch DOID:2763 +property_value: exactMatch http://identifiers.org/snomedct/707359008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333477 +property_value: exactMatch NCIT:C6065 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002418 +name: ethmoid sinus adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the epithelial cell" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of ethmoid sinus" RELATED [DOID:2766] +synonym: "adenocarcinoma of the ethmoid sinus" EXACT [DOID:2766, NCIT:C6237] +xref: DOID:2766 {source="MONDO:equivalentTo"} +xref: NCIT:C6237 {source="MONDO:equivalentTo", source="DOID:2766"} +xref: UMLS:C1333472 {source="MONDO:equivalentTo", source="DOID:2766", source="NCIT:C6237"} +is_a: MONDO:0001763 {source="DOID:2766", source="MONDO:Redundant", source="NCIT:C6237"} ! ethmoid sinus cancer +is_a: MONDO:0004970 {source="DOID:2766/inferred", source="MONDO:Redundant", source="NCIT:C6237/inferred"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002453 ! ethmoid sinus +intersection_of: realized_in_response_to_stimulus CL:0000066 ! epithelial cell +relationship: realized_in_response_to_stimulus CL:0000066 ! epithelial cell +property_value: exactMatch DOID:2766 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333472 +property_value: exactMatch NCIT:C6237 + +[Term] +id: MONDO:0002423 +name: rectosigmoid junction neoplasm +def: "A benign or malignant neoplasm that affects the rectosigmoid region. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Rectosigmoid adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." [NCIT:C4877] +synonym: "neoplasm of rectosigmoid junction" EXACT [MONDO:patterns/neoplasm, NCIT:C4877] +synonym: "neoplasm of the rectosigmoid junction" EXACT [NCIT:C4877] +synonym: "rectosigmoid junction neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "rectosigmoid junction tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "rectosigmoid neoplasm" EXACT [DOID:2780, NCIT:C4877] +synonym: "rectosigmoid tumor" EXACT [DOID:2780, NCIT:C4877] +synonym: "tumor of rectosigmoid junction" EXACT [MONDO:patterns/neoplasm, NCIT:C4877] +synonym: "tumor of the rectosigmoid junction" EXACT [NCIT:C4877] +xref: DOID:2780 {source="MONDO:equivalentTo"} +xref: NCIT:C4877 {source="DOID:2780", source="MONDO:equivalentTo"} +xref: SCTID:126848003 {source="DOID:2780", source="MONDO:equivalentTo"} +xref: UMLS:C0345873 {source="DOID:2780", source="MONDO:equivalentTo", source="NCIT:C4877"} +is_a: MONDO:0006971 {source="DOID:2780"} ! sigmoid neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0036214 ! rectosigmoid junction +relationship: disease_has_location UBERON:0036214 ! rectosigmoid junction +property_value: exactMatch DOID:2780 +property_value: exactMatch http://identifiers.org/snomedct/126848003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345873 +property_value: exactMatch NCIT:C4877 +property_value: excluded_subClassOf MONDO:0002165 {source="DOID:2780"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002424 +name: rectosigmoid carcinoma +def: "A malignant epithelial neoplasm that arises from the rectosigmoid area and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. About 50% of colorectal carcinomas occur in the rectosigmoid area." [NCIT:C7421] +synonym: "carcinoma of rectosigmoid junction" EXACT [MONDO:patterns/carcinoma] +synonym: "rectosigmoid cancer" EXACT [NCIT:C7421] +synonym: "rectosigmoid carcinoma" EXACT [NCIT:C7421] +synonym: "rectosigmoid junction carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:2781 {source="MONDO:equivalentTo"} +xref: NCIT:C7421 {source="DOID:2781", source="MONDO:equivalentTo"} +xref: UMLS:C1327709 {source="DOID:2781", source="NCIT:C7421", source="MONDO:equivalentTo"} +is_a: MONDO:0002032 ! colon carcinoma +is_a: MONDO:0002425 {source="DOID:2781", source="MONDO:Redundant", source="NCIT:C7421"} ! rectosigmoid junction cancer +is_a: MONDO:0044937 ! rectal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0036214 ! rectosigmoid junction +property_value: exactMatch DOID:2781 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1327709 +property_value: exactMatch NCIT:C7421 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002425 +name: rectosigmoid junction cancer +def: "A primary or metastatic malignant neoplasm that affects the rectosigmoid area. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C7420] +synonym: "cancer of rectosigmoid junction" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of rectosigmoid" EXACT [DOID:2782] +synonym: "malignant neoplasm of rectosigmoid junction" EXACT [DOID:2782, ICD9CM:154.0, MONDO:patterns/cancer, NCIT:C7420] +synonym: "malignant neoplasm of the rectosigmoid junction" EXACT [NCIT:C7420] +synonym: "malignant rectosigmoid junction neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant rectosigmoid neoplasm" EXACT [NCIT:C7420] +synonym: "malignant rectosigmoid tumor" EXACT [DOID:2782, NCIT:C7420] +synonym: "malignant tumor of rectosigmoid junction" EXACT [NCIT:C7420] +synonym: "malignant tumor of the rectosigmoid junction" EXACT [NCIT:C7420] +synonym: "rectosigmoid junction cancer" EXACT [MONDO:patterns/location] +xref: DOID:2782 {source="MONDO:equivalentTo"} +xref: ICD10CM:C19 {source="DOID:2782", source="MONDO:equivalentTo"} +xref: ICD9:154.0 {source="DOID:2782", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7420 {source="DOID:2782", source="MONDO:equivalentTo"} +xref: SCTID:363414004 {source="DOID:2782", source="MONDO:equivalentTo"} +xref: UMLS:C0153443 {source="NCIT:C7420", source="DOID:2782", source="MONDO:equivalentTo"} +is_a: MONDO:0001464 {source="DOID:2782", source="MONDO:Redundant"} ! sigmoid colon cancer +is_a: MONDO:0002423 {source="MONDO:Redundant", source="NCIT:C7420"} ! rectosigmoid junction neoplasm +is_a: MONDO:0006519 {source="MONDO:Entailed"} ! rectal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0036214 ! rectosigmoid junction +property_value: exactMatch DOID:2782 +property_value: exactMatch http://identifiers.org/snomedct/363414004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153443 +property_value: exactMatch https://icd.codes/icd10cm/C19 +property_value: exactMatch NCIT:C7420 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002427 +name: cerebellar disorder +def: "Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, gait ataxia, and muscle hypotonia." [MESH:D002526] +synonym: "cerebellum disease" EXACT [MONDO:patterns/location] +synonym: "cerebellum disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of cerebellum" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cerebellum" EXACT [] +synonym: "disorder of cerebellum" EXACT [MONDO:patterns/location_top] +xref: DOID:2786 {source="MONDO:equivalentTo"} +xref: MESH:D002526 {source="MONDO:equivalentTo", source="DOID:2786"} +xref: SCTID:223176004 {source="MONDO:equivalentTo", source="DOID:2786"} +xref: UMLS:C0007760 {source="MONDO:equivalentTo", source="DOID:2786"} +is_a: MONDO:0005560 {source="DOID:2786", source="MESH:D002526", source="MONDO:Redundant"} ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +relationship: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch DOID:2786 +property_value: exactMatch http://identifiers.org/mesh/D002526 +property_value: exactMatch http://identifiers.org/snomedct/223176004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007760 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002432 +name: malignant neoplasm of acoustic nerve +def: "A malignant neoplasm involving the vestibulocochlear nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of the vestibulocochlear nerve" EXACT [NCIT:C4539] +synonym: "cancer of vestibulocochlear nerve" EXACT [MONDO:patterns/cancer] +synonym: "malignant acoustic nerve neoplasm" EXACT [NCIT:C4539] +synonym: "malignant acoustic nerve tumor" EXACT [NCIT:C4539] +synonym: "malignant eighth cranial nerve neoplasm" EXACT [NCIT:C4539] +synonym: "malignant eighth cranial nerve tumor" EXACT [NCIT:C4539] +synonym: "malignant neoplasm of eighth cranial nerve" EXACT [NCIT:C4539] +synonym: "malignant neoplasm of the acoustic nerve" EXACT [NCIT:C4539] +synonym: "malignant neoplasm of the eighth cranial nerve" EXACT [NCIT:C4539] +synonym: "malignant neoplasm of the vestibulocochlear nerve" EXACT [NCIT:C4539] +synonym: "malignant neoplasm of vestibulocochlear nerve" EXACT [MONDO:patterns/cancer, NCIT:C4539] +synonym: "malignant tumor of acoustic nerve" EXACT [NCIT:C4539] +synonym: "malignant tumor of acoustic vestibular nerve" EXACT [DOID:2814] +synonym: "malignant tumor of eighth cranial nerve" EXACT [NCIT:C4539] +synonym: "malignant tumor of the acoustic nerve" EXACT [NCIT:C4539] +synonym: "malignant tumor of the eighth cranial nerve" EXACT [NCIT:C4539] +synonym: "malignant tumor of the vestibulocochlear nerve" EXACT [DOID:2814, NCIT:C4539] +synonym: "malignant tumor of vestibulocochlear nerve" EXACT [NCIT:C4539] +synonym: "malignant tumour of acoustic vestibular nerve" EXACT [DOID:2814] +synonym: "malignant vestibulocochlear nerve neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant vestibulocochlear nerve tumor" EXACT [NCIT:C4539] +synonym: "vestibulocochlear nerve cancer" EXACT [MONDO:patterns/location] +xref: DOID:2814 {source="MONDO:equivalentTo"} +xref: NCIT:C4539 {source="MONDO:equivalentTo", source="DOID:2814"} +xref: SCTID:254980001 {source="MONDO:equivalentTo", source="DOID:2814"} +xref: UMLS:C0346331 {source="MONDO:equivalentTo", source="DOID:2814", source="NCIT:C4539"} +is_a: MONDO:0002433 {source="DOID:2814", source="MONDO:Redundant", source="NCIT:C4539"} ! malignant cranial nerve neoplasm +is_a: MONDO:0004532 {source="DOID:2814", source="MONDO:Entailed", source="MONDO:Redundant"} ! auditory system cancer +is_a: MONDO:0021221 {source="MONDO:Redundant", source="NCIT:C4539"} ! vestibulocochlear nerve neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001648 ! vestibulocochlear nerve +property_value: exactMatch DOID:2814 +property_value: exactMatch http://identifiers.org/snomedct/254980001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346331 +property_value: exactMatch NCIT:C4539 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002433 +name: malignant cranial nerve neoplasm +def: "Abnormal malignant growth of the cells that comprise the cranial nerve." [NCIT:C3571] +synonym: "cancer of cranial nerve" EXACT [MONDO:patterns/cancer] +synonym: "cranial nerve cancer" EXACT [MONDO:patterns/location] +synonym: "cranial nerve malignant neoplasm" RELATED [DOID:2815] +synonym: "cranial nerve neoplasm, malignant" EXACT [NCIT:C3571] +synonym: "malignant cranial nerve neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3571] +synonym: "malignant cranial nerve tumor" EXACT [NCIT:C3571] +synonym: "malignant neoplasm of cranial nerve" EXACT [DOID:2815, MONDO:patterns/cancer, NCIT:C3571] +synonym: "malignant neoplasm of cranial nerves" EXACT [DOID:2815, ICD9CM:192.0] +synonym: "malignant neoplasm of the cranial nerve" EXACT [NCIT:C3571] +synonym: "malignant tumor of cranial nerve" EXACT [NCIT:C3571] +synonym: "malignant tumor of the cranial nerve" EXACT [DOID:2815, NCIT:C3571] +xref: DOID:2815 {source="MONDO:equivalentTo"} +xref: ICD9:192.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2815"} +xref: NCIT:C3571 {source="MONDO:equivalentTo", source="DOID:2815"} +xref: SCTID:188307009 {source="MONDO:equivalentTo", source="DOID:2815"} +xref: UMLS:C0153644 {source="NCIT:C3571", source="MONDO:equivalentTo", source="DOID:2815"} +is_a: MONDO:0002633 {source="DOID:2815", source="MONDO:Redundant", source="NCIT:C3571"} ! cranial nerve neoplasm +is_a: MONDO:0005627 ! head and neck cancer +is_a: MONDO:0021089 ! peripheral nervous system cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001785 ! cranial nerve +property_value: exactMatch DOID:2815 +property_value: exactMatch http://identifiers.org/snomedct/188307009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153644 +property_value: exactMatch NCIT:C3571 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002434 +name: oculomotor nerve cancer +def: "A cancer involving a oculomotor nerve." [MONDO:patterns/cancer] +synonym: "cancer of oculomotor nerve" EXACT [MONDO:patterns/cancer] +synonym: "IIIrd cranial nerve neoplasm, malignant" EXACT [DOID:2816, NCIT:C6995] +synonym: "malignant neoplasm of oculomotor nerve" EXACT [MONDO:patterns/cancer] +synonym: "malignant oculomotor nerve neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant oculomotor nerve tumor" RELATED [DOID:2816] +synonym: "oculomotor nerve cancer" EXACT [MONDO:patterns/location] +synonym: "oculomotor nerve neoplasm, malignant" EXACT [NCIT:C6995] +synonym: "primary malignant neoplasm of oculomotor nerve" EXACT [DOID:2816] +xref: DOID:2816 {source="MONDO:equivalentTo"} +xref: NCIT:C6995 {source="MONDO:equivalentTo", source="DOID:2816"} +xref: SCTID:93929003 {source="MONDO:equivalentTo", source="DOID:2816"} +xref: UMLS:C0686417 {source="MONDO:equivalentTo", source="NCIT:C6995", source="DOID:2816"} +is_a: MONDO:0002433 {source="DOID:2816/inferred", source="MONDO:Redundant", source="NCIT:C6995"} ! malignant cranial nerve neoplasm +is_a: MONDO:0002435 {source="DOID:2816", source="MONDO:Redundant", source="NCIT:C6995"} ! oculomotor nerve neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001643 ! oculomotor nerve +property_value: exactMatch DOID:2816 +property_value: exactMatch http://identifiers.org/snomedct/93929003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686417 +property_value: exactMatch NCIT:C6995 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002435 +name: oculomotor nerve neoplasm +def: "A neoplasm involving a oculomotor nerve." [MONDO:patterns/neoplasm] +synonym: "cranial nerve III tumor" RELATED [DOID:2817] +synonym: "IIIrd cranial nerve tumor" EXACT [NCIT:C6994] +synonym: "neoplasm of oculomotor nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "oculomotor nerve neoplasm" EXACT [NCIT:C6994] +synonym: "oculomotor nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "oculomotor nerve tumor" EXACT [DOID:2817, MONDO:patterns/neoplasm, NCIT:C6994] +synonym: "tumor of oculomotor nerve" EXACT [MONDO:patterns/neoplasm] +xref: DOID:2817 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6994 {source="MONDO:equivalentTo", source="DOID:2817"} +xref: SCTID:126969002 {source="MONDO:equivalentTo", source="DOID:2817"} +xref: UMLS:C1263895 {source="MONDO:equivalentTo", source="NCIT:C6994", source="DOID:2817"} +is_a: MONDO:0002633 {source="DOID:2817/inferred", source="MONDO:Redundant", source="NCIT:C6994"} ! cranial nerve neoplasm +is_a: MONDO:0003546 {source="DOID:2817", source="MONDO:Redundant", source="NCIT:C6994"} ! third cranial nerve disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001643 ! oculomotor nerve +property_value: exactMatch DOID:2817 +property_value: exactMatch http://identifiers.org/snomedct/126969002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263895 +property_value: exactMatch NCIT:C6994 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002436 +name: nasal disorder +def: "A disease involving the nose." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of nose" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nose" EXACT [] +synonym: "disorder of nose" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the nose" EXACT [DOID:2825] +synonym: "nasal disorder" EXACT [DOID:2825] +synonym: "nose disease" EXACT [https://orcid.org/0000-0002-0736-9199, MONDO:patterns/location] +synonym: "nose disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:2825 {source="MONDO:equivalentTo"} +xref: ICD9:478.19 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009668 {source="MONDO:equivalentTo", source="DOID:2825"} +xref: SCTID:89488007 {source="MONDO:equivalentTo", source="DOID:2825"} +xref: UMLS:C0028432 {source="MONDO:equivalentTo", source="DOID:2825"} +is_a: MONDO:0005042 ! head disorder +is_a: MONDO:0024623 {source="https://orcid.org/0000-0002-0736-9199"} ! otorhinolaryngologic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000004 ! nose +relationship: disease_has_location UBERON:0000004 ! nose +property_value: exactMatch DOID:2825 +property_value: exactMatch http://identifiers.org/mesh/D009668 +property_value: exactMatch http://identifiers.org/snomedct/89488007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0028432 +property_value: excluded_subClassOf MONDO:0004867 {source="DOID:2825"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002447 +name: endometrial carcinoma +def: "A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation." [NCIT:C7558] +synonym: "carcinoma of endometrium" EXACT [MONDO:patterns/carcinoma, NCIT:C7558] +synonym: "carcinoma of the endometrium" EXACT [DOID:2871, NCIT:C7558] +synonym: "carcinoma, endometrial, malignant" EXACT [NCIT:C7558] +synonym: "endometrial cancer" BROAD [NCIT:C7558] +synonym: "endometrial carcinoma" EXACT [MONDO:ambiguous, NCIT:C7558] +synonym: "endometrial carcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "endometrium carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:2871 {source="MONDO:equivalentTo"} +xref: HP:0012114 {source="MONDO:otherHierarchy"} +xref: NCIT:C7558 {source="DOID:2871", source="MONDO:equivalentTo"} +xref: ONCOTREE:UCEC {source="MONDO:equivalentTo"} +xref: SCTID:254878006 {source="DOID:2871", source="MONDO:equivalentTo"} +xref: UMLS:C0476089 {source="DOID:2871", source="MONDO:equivalentTo", source="NCIT:C7558"} +is_a: MONDO:0005213 ! uterine carcinoma +is_a: MONDO:0011962 {source="DOID:2871", source="MONDO:Redundant", source="NCIT:C7558"} ! endometrial cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch DOID:2871 +property_value: exactMatch http://identifiers.org/snomedct/254878006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0476089 +property_value: exactMatch NCIT:C7558 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: IAO:0000589 "endometrial carcinoma (disease)" xsd:string + +[Term] +id: MONDO:0002453 +name: retrocochlear disease +def: "Pathological processes involving the vestibulocochlear nerve; brainstem; or central nervous system. When hearing loss is due to retrocochlear pathology, it is called retrocochlear hearing loss." [MESH:D012181] +xref: DOID:2889 {source="MONDO:equivalentTo"} +xref: MESH:D012181 {source="MONDO:equivalentTo", source="DOID:2889"} +xref: UMLS:C0035352 {source="MONDO:equivalentTo", source="DOID:2889"} +is_a: MONDO:0002409 {source="DOID:2889"} ! auditory system disorder +property_value: exactMatch DOID:2889 +property_value: exactMatch http://identifiers.org/mesh/D012181 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035352 + +[Term] +id: MONDO:0002455 +name: exocervical carcinoma +def: "A carcinoma that arises from the squamous epithelium of the exocervix." [NCIT:C7453] +synonym: "carcinoma of ectocervix" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of exocervix" EXACT [DOID:2892, NCIT:C7453] +synonym: "carcinoma of the exocervix" EXACT [DOID:2892, NCIT:C7453] +synonym: "ectocervix carcinoma" EXACT [MONDO:patterns/location] +synonym: "exocervical cancer" EXACT [NCIT:C7453] +synonym: "exocervical carcinoma" EXACT [NCIT:C7453] +synonym: "exocervix carcinoma" EXACT [NCIT:C7453] +xref: DOID:2892 {source="MONDO:equivalentTo"} +xref: NCIT:C7453 {source="DOID:2892", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:372100004 {source="DOID:2892", source="MONDO:equivalentTo"} +xref: UMLS:C1299238 {source="NCIT:C7453", source="DOID:2892", source="MONDO:equivalentTo"} +is_a: MONDO:0005131 {source="DOID:2892", source="MONDO:Redundant", source="NCIT:C7453"} ! cervical carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0012249 ! ectocervix +relationship: disease_has_location UBERON:0012249 ! ectocervix +property_value: exactMatch DOID:2892 +property_value: exactMatch http://identifiers.org/snomedct/372100004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1299238 +property_value: exactMatch NCIT:C7453 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002459 +name: type IV hypersensitivity disease +def: "A disease that has its basis in the disruption of type IV hypersensitivity." [MONDO:patterns/basis_in_disruption_of_process] +comment: We make this equivalent with the UMLS concept for the reaction +synonym: "delayed hypersensitivity reaction" EXACT [NCIT:C3115] +synonym: "delayed-type hypersensitivity" EXACT [NCIT:C3115] +synonym: "delayed-type hypersensitivity response" EXACT [NCIT:C3115] +synonym: "disorder of type IV hypersensitivity" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "DTH" EXACT ABBREVIATION [NCIT:C3115] +synonym: "hypersensitivity reaction type IV disease" RELATED [DOID:2916] +synonym: "immunoproliferative disease" RELATED [DOID:2916] +synonym: "type 4 hypersensitivity reaction" EXACT [NCIT:C3115] +synonym: "type IV hypersensitivity" EXACT [NCIT:C3115] +synonym: "type IV hypersensitivity reaction" EXACT [NCIT:C3115] +xref: DOID:2916 {source="MONDO:equivalentTo"} +xref: NCIT:C3115 {source="MONDO:equivalentTo"} +xref: UMLS:C0020522 {source="MONDO:equivalentTo", source="NCIT:C3115"} +is_a: MONDO:0000605 {source="DOID:2916", source="MONDO:Entailed", source="NCIT:C3115"} ! hypersensitivity reaction disease +is_a: MONDO:0007179 ! autoimmune disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0001806 ! type IV hypersensitivity +relationship: disease_has_basis_in_disruption_of GO:0001806 ! type IV hypersensitivity +property_value: exactMatch DOID:2916 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020522 +property_value: exactMatch NCIT:C3115 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0002460 +name: lacrimal system cancer +def: "A cancer that involves the lacrimal apparatus." [MONDO:patterns/location] +synonym: "cancer of lacrimal apparatus" EXACT [MONDO:patterns/cancer] +synonym: "lacrimal apparatus cancer" EXACT [] +synonym: "lacrimal system neoplasm" EXACT [DOID:292] +synonym: "lacrimal system neoplasms" EXACT [NCIT:C5102] +synonym: "lacrimal system tumor" EXACT [NCIT:C5102] +synonym: "malignant lacrimal apparatus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of lacrimal apparatus" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of lacrimal system" EXACT [NCIT:C5102] +synonym: "neoplasm of the lacrimal system" EXACT [NCIT:C5102] +synonym: "tumor of lacrimal system" EXACT [NCIT:C5102] +synonym: "tumor of the lacrimal system" EXACT [DOID:292, NCIT:C5102] +xref: DOID:292 {source="MONDO:equivalentTo"} +xref: NCIT:C5102 {source="MONDO:equivalentTo", source="DOID:292"} +xref: SCTID:416510003 {source="MONDO:equivalentTo", source="DOID:292"} +xref: UMLS:C1334361 {source="MONDO:equivalentTo", source="DOID:292", source="NCIT:C5102"} +is_a: MONDO:0001854 ! lacrimal apparatus disorder +is_a: MONDO:0002236 ! ocular cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001750 ! lacrimal apparatus +property_value: exactMatch DOID:292 +property_value: exactMatch http://identifiers.org/snomedct/416510003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334361 +property_value: exactMatch NCIT:C5102 +property_value: excluded_subClassOf MONDO:0002236 {source="DOID:292"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002462 +name: glomerulonephritis +def: "A renal disorder characterized by damage in the glomeruli. It may be acute or chronic, focal or diffuse, and it may lead to renal failure. Causes include autoimmune disorders, infections, diabetes, and malignancies." [NCIT:P378] +synonym: "bright's disease" RELATED [GARD:0006516] +synonym: "glomerular nephritis" EXACT [NCIT:C26784] +synonym: "glomerulonephritis" EXACT [MONDO:ambiguous] +synonym: "glomerulonephritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "nephritis of renal glomerulus" EXACT [MONDO:design_pattern] +synonym: "renal glomerulus nephritis" EXACT [MONDO:patterns/location] +xref: DOID:2921 {source="MONDO:equivalentTo"} +xref: GARD:0006516 {source="MONDO:equivalentTo"} +xref: HP:0000099 {source="MONDO:otherHierarchy"} +xref: ICD9:583.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005921 {source="MONDO:equivalentTo", source="DOID:2921"} +xref: NCIT:C26784 {source="MONDO:equivalentTo", source="DOID:2921"} +xref: SCTID:36171008 {source="MONDO:equivalentTo", source="DOID:2921"} +xref: UMLS:C0017658 {source="NCIT:C26784", source="MONDO:equivalentTo", source="DOID:2921"} +is_a: MONDO:0001166 {source="DOID:2921", source="MESH:D005921", source="MONDO:Redundant", source="NCIT:C26784"} ! nephritis +is_a: MONDO:0019722 {source="MONDO:Redundant"} ! glomerular disorder +intersection_of: MONDO:0001166 ! nephritis +intersection_of: disease_has_location UBERON:0000074 ! renal glomerulus +relationship: disease_causes_feature MONDO:0001106 ! kidney failure +relationship: disease_has_feature HP:0000099 ! Glomerulonephritis +property_value: exactMatch DOID:2921 +property_value: exactMatch http://identifiers.org/mesh/D005921 +property_value: exactMatch http://identifiers.org/snomedct/36171008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017658 +property_value: exactMatch NCIT:C26784 +property_value: IAO:0000589 "glomerulonephritis (disease)" xsd:string + +[Term] +id: MONDO:0002463 +name: lacrimal gland carcinoma +def: "A carcinoma that arises from epithelial cells of the lacrimal gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of lacrimal gland" EXACT [MONDO:patterns/carcinoma, NCIT:C6129] +synonym: "carcinoma of the lacrimal gland" EXACT [DOID:293, NCIT:C6129] +synonym: "lacrimal gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C6129] +xref: DOID:293 {source="MONDO:equivalentTo"} +xref: NCIT:C6129 {source="DOID:293", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334358 {source="DOID:293", source="MONDO:equivalentTo", source="NCIT:C6129"} +is_a: MONDO:0002464 {source="DOID:293", source="MONDO:Redundant", source="NCIT:C6129"} ! lacrimal gland cancer +is_a: MONDO:0002466 {source="MONDO:Redundant", source="NCIT:C6129"} ! eye carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch DOID:293 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334358 +property_value: exactMatch NCIT:C6129 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002464 +name: lacrimal gland cancer +def: "A malignant neoplasm involving the lacrimal gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of lacrimal gland" EXACT [MONDO:patterns/cancer] +synonym: "lacrimal gland cancer" EXACT [MONDO:patterns/location] +synonym: "malignant lacrimal gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3563] +synonym: "malignant lacrimal gland tumor" EXACT [NCIT:C3563] +synonym: "malignant neoplasm of lacrimal gland" EXACT [DOID:294, MONDO:patterns/cancer, NCIT:C3563] +synonym: "malignant neoplasm of the lacrimal gland" EXACT [NCIT:C3563] +synonym: "malignant tumor of lacrimal gland" EXACT [NCIT:C3563] +synonym: "malignant tumor of the lacrimal gland" EXACT [NCIT:C3563] +synonym: "malignant tumour of lacrimal gland" EXACT [DOID:294] +synonym: "tumor of the lacrimal gland" BROAD [DOID:294, NCIT:C4360] +xref: DOID:294 {source="MONDO:equivalentTo"} +xref: ICD9:190.2 {source="DOID:294"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3563 {source="MONDO:equivalentTo", source="DOID:294"} +xref: SCTID:127004000 {source="MONDO:equivalentTo", source="DOID:294"} +is_a: MONDO:0002460 {source="DOID:294", source="MONDO:Redundant", source="NCIT:C3563/inferred"} ! lacrimal system cancer +is_a: MONDO:0021222 {source="MONDO:Redundant", source="NCIT:C3563"} ! lacrimal gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch DOID:294 +property_value: exactMatch http://identifiers.org/snomedct/127004000 +property_value: exactMatch NCIT:C3563 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002466 +name: eye carcinoma +def: "A carcinoma that arises from epithelial cells of the eye" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of eye" EXACT [DOID:295, MONDO:patterns/carcinoma, NCIT:C6079] +synonym: "carcinoma of eyeball of camera-type eye" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the eye" EXACT [NCIT:C6079] +synonym: "eye carcinoma" EXACT [MONDO:patterns/location, NCIT:C6079] +synonym: "eyeball of camera-type eye carcinoma" EXACT [] +synonym: "ocular carcinoma" EXACT [DOID:295, NCIT:C6079] +xref: DOID:295 {source="MONDO:equivalentTo"} +xref: NCIT:C6079 {source="MONDO:equivalentTo", source="DOID:295", source="MONDO:exact-label-match"} +xref: UMLS:C0848866 {source="NCIT:C6079", source="MONDO:equivalentTo", source="DOID:295"} +is_a: MONDO:0002038 ! head and neck carcinoma +is_a: MONDO:0002236 {source="DOID:295", source="MONDO:Redundant", source="NCIT:C6079"} ! ocular cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch DOID:295 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0848866 +property_value: exactMatch NCIT:C6079 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002467 +name: inner ear disorder +def: "A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems." [NCIT:C27166] +synonym: "disease of internal ear" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of internal ear" EXACT [] +synonym: "disorder of internal ear" EXACT [MONDO:patterns/location_top] +synonym: "inner Ear disorder" EXACT [NCIT:C27166] +synonym: "internal ear disease" EXACT [MONDO:patterns/location] +synonym: "internal ear disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "internal Ear disorder" EXACT [NCIT:C27166] +synonym: "labyrinthine disease" EXACT [DOID:2952] +synonym: "vestibular disorder" NARROW [NCIT:C27166] +xref: DOID:2952 {source="MONDO:equivalentTo"} +xref: ICD10CM:H80-H83 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="DOID:2952", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: MESH:D007759 {source="DOID:2952", source="MONDO:equivalentTo"} +xref: NCIT:C27166 {source="DOID:2952", source="MONDO:equivalentTo"} +xref: SCTID:232297009 {source="DOID:2952", source="MONDO:equivalentTo"} +is_a: MONDO:0002409 {source="DOID:2952"} ! auditory system disorder +is_a: MONDO:0021205 {source="MONDO:Redundant", source="NCIT:C27166"} ! disorder of ear +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001846 ! internal ear +relationship: disease_has_location UBERON:0001846 {source="NCIT:C27166"} ! internal ear +property_value: exactMatch DOID:2952 +property_value: exactMatch http://identifiers.org/mesh/D007759 +property_value: exactMatch http://identifiers.org/snomedct/232297009 +property_value: exactMatch https://icd.codes/icd10cm/H80-H83 +property_value: exactMatch NCIT:C27166 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002468 +name: hyperimmunoglobulin syndrome +synonym: "hyperimmunoglobulin syndrome" EXACT [NCIT:C27579] +xref: DOID:2959 {source="MONDO:equivalentTo"} +xref: NCIT:C27579 {source="MONDO:equivalentTo", source="DOID:2959"} +xref: UMLS:C1334069 {source="MONDO:equivalentTo", source="NCIT:C27579", source="DOID:2959"} +is_a: MONDO:0002211 {source="DOID:2959"} ! B cell deficiency +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0019814 ! immunoglobulin complex +relationship: disease_has_basis_in_dysfunction_of GO:0019814 ! immunoglobulin complex +property_value: exactMatch DOID:2959 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334069 +property_value: exactMatch NCIT:C27579 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0002475 +name: lacrimal gland adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the lacrimal gland" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of lacrimal gland" EXACT [DOID:298, NCIT:C4541] +synonym: "adenocarcinoma of the lacrimal gland" EXACT [NCIT:C4541] +synonym: "lacrimal gland adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C4541] +xref: DOID:298 {source="MONDO:equivalentTo"} +xref: NCIT:C4541 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:298"} +xref: SCTID:254988008 {source="MONDO:equivalentTo", source="DOID:298"} +xref: UMLS:C0346341 {source="MONDO:equivalentTo", source="NCIT:C4541", source="DOID:298"} +is_a: MONDO:0002463 {source="DOID:298", source="MONDO:Redundant", source="NCIT:C4541"} ! lacrimal gland carcinoma +is_a: MONDO:0004970 {source="DOID:298", source="MONDO:Redundant", source="NCIT:C4541"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch DOID:298 +property_value: exactMatch http://identifiers.org/snomedct/254988008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346341 +property_value: exactMatch NCIT:C4541 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002477 +name: prostate neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the prostate gland. This category includes carcinoid tumors and small cell carcinomas." [NCIT:C5545] +synonym: "neuroendocrine neoplasm of prostate" EXACT [NCIT:C5545] +synonym: "neuroendocrine neoplasm of prostate gland" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of the prostate" EXACT [NCIT:C5545] +synonym: "neuroendocrine tumor of the prostate" EXACT [DOID:2992, NCIT:C5545] +synonym: "prostate gland NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "prostate gland neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "prostate gland neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "prostate gland neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "prostate neuroendocrine carcinoma" RELATED [ONCOTREE:PRNE] +synonym: "prostate neuroendocrine neoplasm" EXACT [NCIT:C5545] +xref: DOID:2992 {source="MONDO:equivalentTo"} +xref: NCIT:C5545 {source="DOID:2992", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:PRNE {source="MONDO:equivalentTo"} +xref: UMLS:C1335515 {source="DOID:2992", source="MONDO:equivalentTo", source="NCIT:C5545"} +is_a: MONDO:0019496 {source="DOID:2992", source="MONDO:Redundant", source="NCIT:C5545"} ! neuroendocrine neoplasm +is_a: MONDO:0021259 {source="MONDO:Redundant", source="NCIT:C5545", source="ONCOTREE:PRNE"} ! prostate neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:2992 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335515 +property_value: exactMatch NCIT:C5545 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0002480 +name: endometrioid tumor +def: "A benign, borderline, or malignant epithelial tumor of the female reproductive system characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells." [NCIT:C7113] +synonym: "endometrioid neoplasm" EXACT [DOID:3001, NCIT:C7113] +synonym: "endometrioid neoplasm of female reproductive system" EXACT [NCIT:C7113] +synonym: "endometrioid neoplasm of the female reproductive system" EXACT [NCIT:C7113] +synonym: "endometrioid tumor" EXACT [NCIT:C7113] +synonym: "endometrioid tumor (morphologic abnormality)" EXACT [DOID:3001] +synonym: "endometrioid tumor of female reproductive system" EXACT [NCIT:C7113] +synonym: "endometrioid tumor of the female reproductive system" EXACT [NCIT:C7113] +synonym: "female reproductive endometrioid cancer" RELATED [DOID:3001] +synonym: "female reproductive endometrioid neoplasm" EXACT [DOID:3001, NCIT:C7113] +synonym: "female reproductive endometrioid tumor" EXACT [NCIT:C7113] +xref: DOID:3001 {source="MONDO:equivalentTo"} +xref: EFO:0009118 {source="MONDO:equivalentTo"} +xref: NCIT:C7113 {source="DOID:3001", source="MONDO:equivalentTo"} +xref: UMLS:C0474809 {source="DOID:3001", source="NCIT:C7113", source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="NCIT:C7113"} ! epithelial neoplasm +is_a: MONDO:0021148 {source="NCIT:C7113"} ! female reproductive system neoplasm +property_value: exactMatch DOID:3001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0474809 +property_value: exactMatch NCIT:C7113 +property_value: excluded_subClassOf MONDO:0001416 {source="DOID:3001"} + +[Term] +id: MONDO:0002481 +name: ovarian neuroendocrine neoplasm +def: "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma." [NCIT:C5237] +synonym: "neuroendocrine neoplasm of ovary" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5237] +synonym: "neuroendocrine neoplasm of the ovary" EXACT [NCIT:C5237] +synonym: "neuroendocrine tumor of ovary" EXACT [DOID:3002, NCIT:C5237] +synonym: "ovarian neuroendocrine neoplasm" EXACT [NCIT:C5237] +synonym: "ovary NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "ovary neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "ovary neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "ovary neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: DOID:3002 {source="MONDO:equivalentTo"} +xref: NCIT:C5237 {source="DOID:3002", source="MONDO:equivalentTo"} +xref: UMLS:C1335172 {source="DOID:3002", source="MONDO:equivalentTo", source="NCIT:C5237"} +is_a: MONDO:0008170 {source="DOID:3002", source="MONDO:Entailed"} ! ovarian cancer +is_a: MONDO:0019496 {source="DOID:3002", source="MONDO:Redundant", source="NCIT:C5237"} ! neuroendocrine neoplasm +is_a: MONDO:0021069 ! malignant endocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:3002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335172 +property_value: exactMatch NCIT:C5237 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0002482 +name: nipple neoplasm +def: "A benign or malignant neoplasm that arises in the area of the nipple." [NCIT:C5212] +synonym: "neoplasm of nipple" EXACT [MONDO:patterns/neoplasm, NCIT:C5212] +synonym: "neoplasm of the nipple" EXACT [NCIT:C5212] +synonym: "nipple neoplasm" EXACT [NCIT:C5212] +synonym: "nipple neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nipple tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5212] +synonym: "tumor of nipple" EXACT [DOID:3003, MONDO:patterns/neoplasm, NCIT:C5212] +synonym: "tumor of the nipple" EXACT [NCIT:C5212] +xref: DOID:3003 {source="MONDO:equivalentTo"} +xref: NCIT:C5212 {source="DOID:3003", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1112166 {source="DOID:3003", source="MONDO:equivalentTo", source="NCIT:C5212"} +is_a: MONDO:0021100 {source="NCIT:C5212"} ! breast neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002030 ! nipple +relationship: disease_has_location UBERON:0002030 ! nipple +property_value: exactMatch DOID:3003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1112166 +property_value: exactMatch NCIT:C5212 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002483 +name: breast myoepithelial tumor +def: "A benign or malignant tumor that arises from the breast and originates from or is composed of myoepithelial cells. Representative examples include adenomyoepithelioma, myoepitheliosis, and malignant myoepithelioma." [NCIT:C40389] +synonym: "breast myoepithelial neoplasm" EXACT [NCIT:C40389] +synonym: "breast myoepithelial tumor" EXACT [MONDO:patterns/location, NCIT:C40389] +xref: DOID:3004 {source="MONDO:equivalentTo"} +xref: NCIT:C40389 {source="DOID:3004", source="MONDO:equivalentTo"} +xref: UMLS:C1511319 {source="DOID:3004", source="MONDO:equivalentTo", source="NCIT:C40389"} +is_a: MONDO:0002380 {source="DOID:3004", source="MONDO:Redundant", source="NCIT:C40389"} ! myoepithelial tumor +is_a: MONDO:0021100 {source="MONDO:Redundant", source="NCIT:C40389/inferred"} ! breast neoplasm +intersection_of: MONDO:0002380 ! myoepithelial tumor +intersection_of: disease_has_location UBERON:0000310 ! breast +relationship: disease_arises_from_structure UBERON:0003244 {source="NCIT:C40389"} ! epithelium of mammary gland +property_value: exactMatch DOID:3004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511319 +property_value: exactMatch NCIT:C40389 + +[Term] +id: MONDO:0002485 +name: breast neuroendocrine neoplasm +def: "A neoplasm that arises from the breast and is composed of cells of neuroendocrine origin. Most cases are neuroendocrine carcinomas. Primary carcinoid tumors of the breast are very rare." [NCIT:C5169] +synonym: "breast endocrine neoplasm" EXACT [NCIT:C5169] +synonym: "breast NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "breast neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5169] +synonym: "breast neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "breast neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of breast" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5169] +synonym: "neuroendocrine neoplasm of the breast" EXACT [NCIT:C5169] +synonym: "neuroendocrine tumor of the breast" EXACT [DOID:3009, NCIT:C5169] +xref: DOID:3009 {source="MONDO:equivalentTo"} +xref: NCIT:C5169 {source="MONDO:equivalentTo", source="DOID:3009", source="MONDO:exact-label-match"} +xref: UMLS:C1332635 {source="MONDO:equivalentTo", source="NCIT:C5169", source="DOID:3009"} +is_a: MONDO:0019496 {source="DOID:3009", source="MONDO:Redundant", source="NCIT:C5169"} ! neuroendocrine neoplasm +is_a: MONDO:0021100 {source="MONDO:Redundant", source="NCIT:C5169"} ! breast neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:3009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332635 +property_value: exactMatch NCIT:C5169 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0002488 +name: intraductal breast neoplasm +def: "A benign or malignant epithelial neoplasm that arises anywhere in the ductal system of the breast. This category includes intraductal papilloma, intraductal papillary carcinoma, ductal hyperplasia with or without atypia, and ductal carcinoma in situ." [NCIT:C36083] +synonym: "intraductal breast neoplasm" EXACT [NCIT:C36083] +xref: DOID:3013 {source="MONDO:equivalentTo"} +xref: NCIT:C36083 {source="DOID:3013", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0948967 {source="DOID:3013", source="MONDO:equivalentTo", source="NCIT:C36083"} +is_a: MONDO:0021100 {source="NCIT:C36083"} ! breast neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure UBERON:0001765 ! mammary duct +relationship: disease_arises_from_structure UBERON:0001765 ! mammary duct +property_value: exactMatch DOID:3013 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0948967 +property_value: exactMatch NCIT:C36083 + +[Term] +id: MONDO:0002492 +name: acute kidney failure +def: "Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria." [NCIT:C26808] +synonym: "acute kidney injury" EXACT [NCIT:C26808] +synonym: "acute renal failure" EXACT [NCIT:C26808] +synonym: "AKI" EXACT ABBREVIATION [NCIT:C26808] +synonym: "ARF" EXACT ABBREVIATION [NCIT:C26808] +synonym: "kidney failure, acute" EXACT [MONDO:patterns/acute] +xref: DOID:3021 {source="MONDO:equivalentTo"} +xref: ICD10CM:N17 {source="MONDO:equivalentTo"} +xref: MESH:D058186 {source="MONDO:equivalentTo"} +xref: NCIT:C26808 {source="MONDO:equivalentTo"} +is_a: MONDO:0001106 {source="DOID:3021", source="MESH:D058186", source="MONDO:Redundant", source="NCIT:C26808"} ! kidney failure +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0001106 ! kidney failure +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:3021 +property_value: exactMatch http://identifiers.org/mesh/D058186 +property_value: exactMatch https://icd.codes/icd10cm/N17 +property_value: exactMatch NCIT:C26808 + +[Term] +id: MONDO:0002493 +name: prostatic acinar adenocarcinoma +def: "An invasive adenocarcinoma of the prostate gland composed of secretory cells. It is the most common histologic type of prostate adenocarcinoma. Several morphologic variants exist, including atrophic, pseudohyperplastic, foamy gland, and oncocytic variants." [NCIT:P378] +synonym: "acinar adenocarcinoma of prostate" EXACT [NCIT:C5596] +synonym: "acinar adenocarcinoma of the prostate" EXACT [NCIT:C5596] +synonym: "acinar prostate adenocarcinoma" EXACT [NCIT:C5596] +synonym: "prostate acinar adenocarcinoma" EXACT [NCIT:C5596] +synonym: "prostatic acinar adenocarcinoma" EXACT [DOID:3024, NCIT:C5596] +xref: DOID:3024 {source="MONDO:equivalentTo"} +xref: NCIT:C5596 {source="DOID:3024", source="MONDO:equivalentTo"} +xref: UMLS:C1332139 {source="DOID:3024", source="NCIT:C5596", source="MONDO:equivalentTo"} +is_a: MONDO:0004965 {source="MONDO:Redundant", source="NCIT:C5596"} ! acinar cell carcinoma +is_a: MONDO:0005082 {source="DOID:3024", source="MONDO:Redundant", source="NCIT:C5596"} ! prostate adenocarcinoma +intersection_of: MONDO:0004965 {source="NCIT:C5596"} ! acinar cell carcinoma +intersection_of: MONDO:0005082 {source="NCIT:C5596"} ! prostate adenocarcinoma +property_value: exactMatch DOID:3024 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332139 +property_value: exactMatch NCIT:C5596 + +[Term] +id: MONDO:0002494 +name: substance-related disorder +def: "A category of psychiatric disorders which include disorders related to the taking of a drug of abuse (including alcohol, prescribed medications and recreational drugs)." [NCIT:C92203] +synonym: "substance-related disorder" EXACT [NCIT:C92203] +xref: DOID:303 {source="MONDO:equivalentTo"} +xref: ICD10CM:F10-F19 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: MESH:D019966 {source="DOID:303", source="MONDO:equivalentTo"} +xref: NCIT:C92203 {source="DOID:303", source="MONDO:equivalentTo"} +is_a: MONDO:0002025 {source="DOID:303", source="MESH:D019966", source="NCIT:C92203"} ! psychiatric disorder +property_value: exactMatch DOID:303 +property_value: exactMatch http://identifiers.org/mesh/D019966 +property_value: exactMatch https://icd.codes/icd10cm/F10-F19 +property_value: exactMatch NCIT:C92203 + +[Term] +id: MONDO:0002501 +name: brain glioblastoma +def: "A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor." [NCIT:C4642] +synonym: "brain glioblastoma" EXACT [DOID:3073, NCIT:C4642] +synonym: "brain glioblastoma (disease)" EXACT [MONDO:patterns/location] +synonym: "brain glioblastoma multiforme" EXACT [NCIT:C4642] +synonym: "brain glioblastoma multiforme (disease)" EXACT [MONDO:patterns/location] +synonym: "glioblastoma (disease) of brain" EXACT [] +synonym: "glioblastoma multiforme of brain" EXACT [DOID:3073, NCIT:C4642] +synonym: "glioblastoma multiforme of the brain" EXACT [NCIT:C4642] +synonym: "grade IV astrocytic neoplasm of brain" EXACT [NCIT:C4642] +synonym: "grade IV astrocytic neoplasm of the brain" EXACT [NCIT:C4642] +synonym: "grade IV astrocytic tumor of brain" EXACT [NCIT:C4642] +synonym: "grade IV astrocytic tumor of the brain" EXACT [NCIT:C4642] +synonym: "grade IV brain astrocytic neoplasm" EXACT [NCIT:C4642] +synonym: "grade IV brain astrocytic tumor" EXACT [NCIT:C4642] +xref: DOID:3073 {source="MONDO:equivalentTo"} +xref: EFO:0006545 {source="MONDO:equivalentTo"} +xref: NCIT:C4642 {source="MONDO:equivalentTo", source="DOID:3073"} +xref: SCTID:276828006 {source="MONDO:equivalentTo", source="DOID:3073"} +xref: UMLS:C0349543 {source="MONDO:equivalentTo", source="NCIT:C4642", source="DOID:3073"} +is_a: MONDO:0005499 {source="DOID:3073", source="EFO:0006545/inferred", source="MONDO:Redundant"} ! brain glioma +is_a: MONDO:0018177 {source="DOID:3073", source="MONDO:Redundant", source="NCIT:C4642"} ! glioblastoma +intersection_of: MONDO:0018177 ! glioblastoma +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:3073 +property_value: exactMatch http://identifiers.org/snomedct/276828006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349543 +property_value: exactMatch NCIT:C4642 + +[Term] +id: MONDO:0002505 +name: childhood astrocytic tumor +def: "An astrocytic tumor appearing before the age of twenty one without designation of benign or malignant nor designated location." [NCIT:C9022] +synonym: "astrocytic tumor" BROAD [NCIT:C9022] +synonym: "astrocytic tumor of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "astrocytic tumors, childhood" EXACT [NCIT:C9022] +synonym: "childhood astrocytic neoplasm" EXACT [NCIT:C9022] +synonym: "childhood astrocytic tumor" EXACT [NCIT:C9022] +synonym: "childhood astrocytic tumour" EXACT [NCIT:C9022] +synonym: "juvenile astrocytoma" EXACT [DOID:3079] +synonym: "juvenile astrocytoma (morphologic abnormality)" EXACT [DOID:3079] +synonym: "pediatric astrocytic neoplasm" EXACT [NCIT:C9022] +synonym: "pediatric astrocytic tumor" EXACT [MONDO:patterns/childhood, NCIT:C9022] +synonym: "pediatric astrocytoma" EXACT [DOID:3079, NCIT:C9022] +xref: DOID:3079 {source="MONDO:equivalentTo"} +xref: NCIT:C9022 {source="DOID:3079", source="MONDO:equivalentTo"} +xref: UMLS:C1321865 {source="DOID:3079", source="MONDO:equivalentTo", source="NCIT:C9022"} +is_a: MONDO:0021079 ! childhood neoplasm +is_a: MONDO:0021636 {source="DOID:3079", source="MONDO:Redundant", source="NCIT:C9022"} ! astrocytic tumor +intersection_of: MONDO:0021636 ! astrocytic tumor +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:3079 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1321865 +property_value: exactMatch NCIT:C9022 +property_value: excluded_subClassOf MONDO:0019781 {source="DOID:3079"} + +[Term] +id: MONDO:0002508 +name: gingivitis +def: "A disorder involving inflammation of the gums; may affect surrounding and supporting structures of the teeth." [NCIT:C34636] +synonym: "acute gingivitis" NARROW [DOID:3087] +synonym: "chronic gingivitis" NARROW [DOID:3087, ICD9CM:523.1] +synonym: "gingiva inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "gingivitis" EXACT [NCIT:C34636] +synonym: "inflammation of gingiva" EXACT [] +xref: DOID:3087 {source="MONDO:equivalentTo"} +xref: ICD9:523.0 {source="DOID:3087"} +xref: ICD9:523.1 {source="DOID:3087"} +xref: ICD9:523.10 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005891 {source="MONDO:equivalentTo", source="DOID:3087"} +xref: NCIT:C34636 {source="MONDO:equivalentTo", source="DOID:3087"} +xref: SCTID:66383009 {source="MONDO:equivalentTo", source="DOID:3087"} +xref: UMLS:C0017574 {source="MONDO:equivalentTo", source="DOID:3087", source="NCIT:C34636"} +is_a: MONDO:0002021 {source="DOID:3087", source="MESH:D005891", source="MONDO:Redundant"} ! gingival disorder +is_a: MONDO:0004842 ! stomatitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001828 ! gingiva +relationship: disease_has_inflammation_site UBERON:0001828 ! gingiva +property_value: exactMatch DOID:3087 +property_value: exactMatch http://identifiers.org/mesh/D005891 +property_value: exactMatch http://identifiers.org/snomedct/66383009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017574 +property_value: exactMatch NCIT:C34636 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002513 +name: kidney benign neoplasm +def: "A non-metastasizing neoplasm that arises from the kidney. Representative examples include cystic nephroma, metanephric adenoma, oncocytoma, and urothelial papilloma of the renal pelvis." [NCIT:C4778] +synonym: "benign kidney neoplasm" EXACT [NCIT:C4778] +synonym: "benign kidney tumor" EXACT [NCIT:C4778] +synonym: "benign neoplasm of kidney" EXACT [NCIT:C4778] +synonym: "benign neoplasm of the kidney" EXACT [NCIT:C4778] +synonym: "benign renal neoplasm" EXACT [NCIT:C4778] +synonym: "benign renal tumor" EXACT [NCIT:C4778] +synonym: "benign tumor of kidney" EXACT [NCIT:C4778] +synonym: "benign tumor of the kidney" EXACT [NCIT:C4778] +synonym: "kidney benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "renal and ureteral tumor" EXACT [DOID:3116, NCIT:C7514] +synonym: "renal neoplasm, benign" EXACT [NCIT:C4778] +synonym: "renal tumor, benign" EXACT [NCIT:C4778] +xref: DOID:3116 {source="MONDO:equivalentTo"} +xref: EFO:1000111 {source="MONDO:equivalentTo"} +xref: ICD9:223.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4778 {source="MONDO:equivalentTo"} +xref: SCTID:92165001 {source="MONDO:equivalentTo"} +is_a: MONDO:0004180 {source="DOID:3116", source="MONDO:Redundant", source="NCIT:C4778"} ! benign urinary system neoplasm +is_a: MONDO:0021163 {source="MONDO:Redundant", source="NCIT:C4778"} ! kidney neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch DOID:3116 +property_value: exactMatch http://identifiers.org/snomedct/92165001 +property_value: exactMatch NCIT:C4778 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0002514 +name: hepatobiliary neoplasm +def: "A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma." [NCIT:C8614] +synonym: "hepatic and biliary neoplasms" EXACT [NCIT:C8614] +synonym: "hepatic and biliary tumors" EXACT [NCIT:C8614] +synonym: "hepatic, biliary, and gallbladder neoplasms" EXACT [NCIT:C8614] +synonym: "hepato-biliary neoplasm" EXACT [NCIT:C8614] +synonym: "hepato-biliary tumor" EXACT [NCIT:C8614] +synonym: "hepatobiliary benign neoplasm" RELATED [DOID:3117] +synonym: "hepatobiliary neoplasm" EXACT [NCIT:C8614] +synonym: "hepatobiliary system neoplasm" EXACT [] +synonym: "hepatobiliary system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "hepatobiliary system tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "hepatobiliary tumor" EXACT [NCIT:C8614] +synonym: "hepatobiliary tumors" EXACT [DOID:3117, NCIT:C8614] +synonym: "liver and biliary neoplasm" EXACT [NCIT:C8614] +synonym: "liver and biliary system neoplasm" EXACT [NCIT:C8614] +synonym: "neoplasm of hepatobiliary system" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of hepatobiliary system" EXACT [MONDO:patterns/neoplasm] +xref: DOID:3117 {source="MONDO:equivalentTo"} +xref: EFO:0008550 {source="MONDO:equivalentTo"} +xref: NCIT:C8614 {source="DOID:3117", source="MONDO:equivalentTo"} +xref: UMLS:C0854196 {source="DOID:3117", source="MONDO:equivalentTo", source="NCIT:C8614"} +is_a: MONDO:0002515 ! hepatobiliary disorder +is_a: MONDO:0021223 {source="EFO:0008550", source="MONDO:Redundant", source="NCIT:C8614"} ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002423 ! hepatobiliary system +property_value: exactMatch DOID:3117 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854196 +property_value: exactMatch NCIT:C8614 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002515 +name: hepatobiliary disorder +def: "A non-neoplastic or neoplastic disorder that affects the liver, bile ducts, and gallbladder. Representative examples of non-neoplastic disorders include hepatitis, cirrhosis, cholangitis, and cholecystitis. Representative examples of neoplastic disorders include hepatocellular adenoma, hepatocellular carcinoma, and cholangiocarcinoma." [NCIT:P378] +synonym: "disease of hepatobiliary system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of hepatobiliary system" EXACT [] +synonym: "disorder of hepatobiliary system" EXACT [MONDO:patterns/location_top] +synonym: "hepatobiliary disorder" EXACT [NCIT:C3959] +synonym: "hepatobiliary system disease" EXACT [MONDO:patterns/location] +synonym: "hepatobiliary system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "liver and biliary disease" EXACT [NCIT:C3959] +synonym: "liver and biliary disorder" EXACT [NCIT:C3959] +synonym: "liver and biliary system disorder" EXACT [NCIT:C3959] +synonym: "liver and biliary tract disease" EXACT [DOID:3118] +xref: DOID:3118 {source="MONDO:equivalentTo"} +xref: NCIT:C3959 {source="MONDO:equivalentTo", source="DOID:3118"} +xref: UMLS:C0267792 {source="MONDO:equivalentTo", source="DOID:3118"} +is_a: MONDO:0004335 {source="DOID:3118", source="MONDO:Redundant", source="NCIT:C3959"} ! digestive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002423 ! hepatobiliary system +relationship: disease_has_location UBERON:0002423 ! hepatobiliary system +property_value: exactMatch DOID:3118 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267792 +property_value: exactMatch NCIT:C3959 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002516 +name: digestive system cancer +def: "A primary or metastatic malignant neoplasm involving any part of the digestive system." [NCIT:C4890] +synonym: "cancer of digestive system" EXACT [MONDO:patterns/cancer] +synonym: "digestive system cancer" EXACT [DOID:3119, MONDO:patterns/location] +synonym: "gastrointestinal system cancer" EXACT [NCIT:C4890] +synonym: "gastrointestinal tract cancer" EXACT [DOID:3119, NCIT:C4890] +synonym: "GI tumor" BROAD [DOID:3119, NCIT:C3052] +synonym: "malignant digestive system neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4890] +synonym: "malignant gastrointestinal neoplasm" EXACT [NCIT:C4890] +synonym: "malignant gastrointestinal system neoplasm" EXACT [NCIT:C4890] +synonym: "malignant neoplasm of digestive system" EXACT [MONDO:patterns/cancer] +xref: DOID:3119 {source="MONDO:equivalentTo"} +xref: ICD10CM:C15-C26 {source="MONDO:equivalentTo"} +xref: ICD9:239.0 {source="DOID:3119"} +xref: NCIT:C4890 {source="MONDO:equivalentTo", source="DOID:3119"} +is_a: MONDO:0004335 {source="DOID:3119", source="NCIT:C4890/inferred"} ! digestive system disorder +is_a: MONDO:0004992 {source="DOID:3119", source="DOID:3119/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0021223 {source="MONDO:Redundant", source="NCIT:C4890"} ! digestive system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001007 ! digestive system +property_value: exactMatch DOID:3119 +property_value: exactMatch https://icd.codes/icd10cm/C15-C26 +property_value: exactMatch NCIT:C4890 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002518 +name: gallbladder papillary neoplasm +def: "A non-invasive, papillary epithelial neoplasm that arises from the epithelium of the gallbladder. Intraepithelial neoplasia is present." [NCIT:C7130] +synonym: "gall bladder papillary epithelial neoplasm" EXACT [MONDO:patterns/location] +synonym: "gallbladder papillary neoplasm" EXACT [NCIT:C7130] +synonym: "gallbladder papillomatosis" EXACT [NCIT:C7130] +synonym: "intracystic papillary neoplasm" EXACT [NCIT:C7130] +xref: DOID:3120 {source="MONDO:equivalentTo"} +xref: NCIT:C7130 {source="MONDO:equivalentTo", source="DOID:3120"} +xref: UMLS:C1333754 {source="MONDO:equivalentTo", source="DOID:3120", source="NCIT:C7130"} +is_a: MONDO:0021096 {source="MONDO:Redundant", source="NCIT:C7130"} ! papillary epithelial neoplasm +is_a: MONDO:0021253 {source="MONDO:Redundant", source="NCIT:C7130"} ! gallbladder neoplasm +intersection_of: MONDO:0021096 ! papillary epithelial neoplasm +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:3120 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333754 +property_value: exactMatch NCIT:C7130 +property_value: excluded_subClassOf MONDO:0005304 {source="DOID:3120"} + +[Term] +id: MONDO:0002519 +name: anus disorder +def: "A non-neoplastic or neoplastic disorder that affects the anal canal or anal margin. Representative examples of non-neoplastic disorders include hemorrhoids and anal ulcer. Representative examples of neoplastic disorders include carcinoma, lymphoma, and melanoma." [NCIT:C26695] +synonym: "anal disease" EXACT [DOID:3128] +synonym: "anal disorder" EXACT [NCIT:C26695] +synonym: "anal fissure" EXACT [DOID:3128] +synonym: "anal fissure and fistula" EXACT [DOID:3128] +synonym: "anal ulcer" EXACT [DOID:3128] +synonym: "anus disease" EXACT [MONDO:patterns/location] +synonym: "anus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of anus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of anus" EXACT [] +synonym: "disorder of anal region" EXACT [] +synonym: "disorder of anus" EXACT [MONDO:patterns/location_top] +synonym: "fissure in ano" EXACT [DOID:3128] +synonym: "nontraumatic tear of anus" EXACT [DOID:3128] +synonym: "solitary anal ulcer" EXACT [DOID:3128] +synonym: "Ulcer of anus" EXACT [DOID:3128] +xref: DOID:3128 {source="MONDO:equivalentTo"} +xref: MESH:D001004 {source="DOID:3128", source="MONDO:equivalentTo"} +xref: NCIT:C26695 {source="DOID:3128", source="MONDO:equivalentTo"} +xref: SCTID:32110003 {source="DOID:3128", source="MONDO:equivalentTo"} +xref: UMLS:C0003462 {source="NCIT:C26695", source="DOID:3128", source="MONDO:equivalentTo"} +xref: UMLS:C0016167 {source="MONDO:equivalentTo"} +xref: UMLS:C1301262 {source="MONDO:equivalentTo"} +is_a: MONDO:0001593 {source="DOID:3128", source="MESH:D001004"} ! rectal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001245 ! anus +relationship: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:3128 +property_value: exactMatch http://identifiers.org/mesh/D001004 +property_value: exactMatch http://identifiers.org/snomedct/32110003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003462 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0016167 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1301262 +property_value: exactMatch NCIT:C26695 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002525 +name: inherited lipid metabolism disorder +def: "An inherited metabolic disorder caused by an enzyme deficiency, resulting in an inability to oxidize fatty acids for energy production." [NCIT:C97092] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:309005"} +synonym: "disorder of lipid metabolism" BROAD [MONDO:0017707] +synonym: "dyslipidemia" BROAD [DOID:3146] +synonym: "fatty acid metabolism disorder" RELATED [DOID:3146] +synonym: "lipid metabolism disorder" BROAD [DOID:3146] +xref: DOID:3146 {source="MONDO:equivalentTo"} +xref: ICD9:272.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:272.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10061227 {source="Orphanet:309005/e", source="Orphanet:309005"} +xref: NCIT:C97092 {source="MONDO:equivalentTo"} +xref: Orphanet:309005 {source="MONDO:equivalentTo"} +xref: SCTID:267431006 {source="MONDO:equivalentTo"} +xref: UMLS:C0154251 {source="NCIT:C97092", source="Orphanet:309005/e", source="MONDO:equivalentTo", source="Orphanet:309005"} +is_a: MONDO:0019052 {source="DOID:3146", source="MONDO:Redundant", source="NCIT:C97092", source="Orphanet:309005"} ! inborn errors of metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_disrupts GO:0006629 ! lipid metabolic process +relationship: disease_disrupts GO:0006629 ! lipid metabolic process +property_value: closeMatch http://identifiers.org/meddra/10061227 +property_value: exactMatch DOID:3146 +property_value: exactMatch http://identifiers.org/snomedct/267431006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154251 +property_value: exactMatch NCIT:C97092 +property_value: exactMatch Orphanet:309005 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0002529 +name: skin squamous cell carcinoma +def: "A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated." [NCIT:C4819] +synonym: "CSCC" RELATED ABBREVIATION [ONCOTREE:CSCC] +synonym: "cutaneous squamous cell carcinoma" EXACT [NCIT:C4819] +synonym: "epidermoid carcinoma of skin" EXACT [NCIT:C4819] +synonym: "epidermoid carcinoma of the skin" EXACT [NCIT:C4819] +synonym: "epidermoid skin carcinoma" EXACT [DOID:3151, NCIT:C4819] +synonym: "skin squamous cell cancer" EXACT [NCIT:C4819] +synonym: "skin squamous cell carcinoma" EXACT [NCIT:C4819] +synonym: "squamous cell carcinoma - skin" EXACT [NCIT:C4819] +synonym: "squamous cell carcinoma of skin" EXACT [DOID:3151, NCIT:C4819] +synonym: "squamous cell carcinoma of the skin" EXACT [NCIT:C4819] +synonym: "squamous cell skin carcinoma" EXACT [NCIT:C4819] +synonym: "zone of skin squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3151 {source="MONDO:equivalentTo"} +xref: EFO:1001927 {source="MONDO:equivalentTo"} +xref: NCIT:C4819 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3151"} +xref: ONCOTREE:CSCC {source="MONDO:equivalentTo"} +xref: SCTID:254651007 {source="MONDO:equivalentTo", source="DOID:3151"} +xref: UMLS:C0553723 {source="NCIT:C4819", source="MONDO:equivalentTo", source="DOID:3151"} +is_a: MONDO:0002656 {source="DOID:3151", source="MONDO:Redundant", source="NCIT:C4819"} ! skin carcinoma +is_a: MONDO:0005096 {source="DOID:3151", source="EFO:1001927", source="MONDO:Redundant", source="NCIT:C4819"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:3151 +property_value: exactMatch http://identifiers.org/snomedct/254651007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0553723 +property_value: exactMatch NCIT:C4819 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002531 +name: skin neoplasm +def: "A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma." [NCIT:P378] +synonym: "neoplasm of skin" EXACT [NCIT:C3372] +synonym: "neoplasm of skin by site" EXACT [DOID:3165] +synonym: "neoplasm of the skin" EXACT [NCIT:C3372] +synonym: "neoplasm of zone of skin" EXACT [MONDO:patterns/neoplasm] +synonym: "skin" RELATED [ONCOTREE:SKIN] +synonym: "skin benign neoplasm" RELATED [DOID:3165] +synonym: "skin neoplasm" EXACT [DOID:3165, NCIT:C3372] +synonym: "skin neoplasms" EXACT [NCIT:C3372] +synonym: "skin tumor" EXACT [NCIT:C3372] +synonym: "tumor of skin" EXACT [NCIT:C3372] +synonym: "tumor of the skin" EXACT [DOID:3165, NCIT:C3372] +synonym: "tumor of zone of skin" EXACT [MONDO:patterns/neoplasm] +synonym: "zone of skin neoplasm" EXACT [] +synonym: "zone of skin neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "zone of skin tumor" EXACT [MONDO:patterns/neoplasm] +xref: DOID:3165 {source="MONDO:equivalentTo"} +xref: EFO:0004198 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012878 {source="DOID:3165", source="MONDO:equivalentTo"} +xref: NCIT:C3372 {source="DOID:3165", source="MONDO:equivalentTo"} +xref: ONCOTREE:SKIN {source="MONDO:equivalentTo"} +xref: SCTID:126488004 {source="DOID:3165", source="MONDO:equivalentTo"} +xref: UMLS:C0037286 {source="DOID:3165", source="NCIT:C3372", source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="DOID:3165/inferred", source="MESH:D012878/inferred", source="MONDO:Redundant", source="NCIT:C3372/inferred"} ! neoplasm +is_a: MONDO:0005093 {source="MESH:D012878", source="MONDO:Redundant", source="NCIT:C3372"} ! skin disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:3165 +property_value: exactMatch http://identifiers.org/mesh/D012878 +property_value: exactMatch http://identifiers.org/snomedct/126488004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037286 +property_value: exactMatch NCIT:C3372 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002532 +name: squamous cell neoplasm +def: "A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example." [NCIT:C3792] +synonym: "epidermoid cell neoplasm" EXACT [NCIT:C3792] +synonym: "epidermoid cell tumor" EXACT [DOID:3168, NCIT:C3792] +synonym: "squamous cell neoplasm" EXACT [NCIT:C3792] +synonym: "squamous cell tumor" EXACT [NCIT:C3792] +synonym: "squamous cell tumor (qualifier value)" EXACT [DOID:3168] +xref: DOID:3168 {source="MONDO:equivalentTo"} +xref: MESH:D018307 {source="DOID:3168", source="MONDO:equivalentTo"} +xref: NCIT:C3792 {source="DOID:3168", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0206720 {source="DOID:3168", source="NCIT:C3792", source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="MESH:D018307", source="NCIT:C3792"} ! epithelial neoplasm +property_value: exactMatch DOID:3168 +property_value: exactMatch http://identifiers.org/mesh/D018307 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206720 +property_value: exactMatch NCIT:C3792 + +[Term] +id: MONDO:0002534 +name: fallopian tube papilloma +def: "A benign epithelial neoplasm that arises from the fallopian tube. It is characterized by the presence of fibrovascular stalks lined by serous epithelial cells." [NCIT:C40112] +synonym: "fallopian tube papilloma" EXACT [MONDO:patterns/location, NCIT:C40112] +synonym: "fallopian tube serous papilloma" EXACT [NCIT:C40112] +xref: DOID:3173 {source="MONDO:equivalentTo"} +xref: NCIT:C40112 {source="MONDO:equivalentTo", source="DOID:3173"} +xref: UMLS:C1517123 {source="MONDO:equivalentTo", source="DOID:3173", source="NCIT:C40112"} +is_a: MONDO:0000645 {source="DOID:3173", source="MONDO:Redundant", source="NCIT:C40112"} ! fallopian tube benign neoplasm +is_a: MONDO:0002363 {source="MONDO:Redundant", source="NCIT:C40112"} ! papilloma +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:3173 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1517123 +property_value: exactMatch NCIT:C40112 + +[Term] +id: MONDO:0002536 +name: skin papilloma +def: "A benign papillary neoplastic growth on the skin composed of epithelial cells and a fibrous stalk. It usually develops in the eyelid, axilla, neck, upper chest, and groin." [NCIT:C4614] +synonym: "basosquamous tumor, benign" EXACT [NCIT:C4614] +synonym: "cutaneous papilloma" EXACT [DOID:3178, NCIT:C4614] +synonym: "papilloma of skin" EXACT [DOID:3178, NCIT:C4614] +synonym: "papilloma of the skin" EXACT [NCIT:C4614] +synonym: "skin papilloma" EXACT [NCIT:C4614] +synonym: "zone of skin papilloma" EXACT [MONDO:patterns/location] +xref: DOID:3178 {source="MONDO:equivalentTo"} +xref: NCIT:C4614 {source="DOID:3178", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:255184001 {source="DOID:3178", source="MONDO:equivalentTo"} +xref: UMLS:C0347390 {source="DOID:3178", source="MONDO:equivalentTo", source="NCIT:C4614"} +is_a: MONDO:0002363 {source="DOID:3178", source="MONDO:Redundant", source="NCIT:C4614"} ! papilloma +is_a: MONDO:0024666 ! benign epithelial skin neoplasm +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:3178 +property_value: exactMatch http://identifiers.org/snomedct/255184001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347390 +property_value: exactMatch NCIT:C4614 + +[Term] +id: MONDO:0002542 +name: spinal cord glioma +def: "A neoplasm that arises from glial cells in the spinal cord. Representative examples include astrocytoma, oligodendroglioma, and ependymoma." [NCIT:C4534] +synonym: "glial neoplasm spinal cord" EXACT [DOID:3185, NCIT:C4534] +synonym: "glial tumor of spinal cord" EXACT [NCIT:C4534] +synonym: "glioma of spinal cord" EXACT [DOID:3185] +synonym: "malignant glioma of spinal cord" EXACT [MONDO:design_pattern] +synonym: "spinal cord glial neoplasm" EXACT [NCIT:C4534] +synonym: "spinal cord glial tumor" EXACT [NCIT:C4534] +synonym: "spinal cord glioma" EXACT [NCIT:C4534] +synonym: "spinal cord malignant glioma" EXACT [MONDO:patterns/location] +xref: DOID:3185 {source="MONDO:equivalentTo"} +xref: NCIT:C4534 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3185"} +xref: SCTID:254946004 {source="MONDO:equivalentTo"} +xref: UMLS:C2937245 {source="MONDO:equivalentTo"} +is_a: MONDO:0003544 {source="DOID:3185", source="MONDO:Entailed", source="MONDO:Redundant"} ! spinal cord cancer +is_a: MONDO:0100342 {source="DOID:3185", source="MONDO:Redundant"} ! malignant glioma +intersection_of: MONDO:0100342 ! malignant glioma +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:3185 +property_value: exactMatch http://identifiers.org/snomedct/254946004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2937245 +property_value: exactMatch NCIT:C4534 + +[Term] +id: MONDO:0002545 +name: spinal cord disorder +def: "A disease involving the spinal cord." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of spinal cord" EXACT [MONDO:patterns/location_top] +synonym: "disease of the spinal cord" EXACT [ISBN-13:978-1-259-64403-0] +synonym: "disease or disorder of spinal cord" EXACT [] +synonym: "disorder of spinal cord" EXACT [MONDO:patterns/location_top] +synonym: "myelopathy" RELATED [DOID:319] +synonym: "spinal cord disease" EXACT [MONDO:patterns/location] +synonym: "spinal cord disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "spinal cord disorder" EXACT [NCIT:C97110] +xref: DOID:319 {source="MONDO:equivalentTo"} +xref: ICD9:336.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:336.9 {source="MONDO:equivalentTo", source="DOID:319", source="MONDO:i2s"} +xref: MESH:D013118 {source="MONDO:equivalentTo", source="DOID:319"} +xref: NCIT:C97110 {source="MONDO:equivalentTo", source="DOID:319"} +xref: SCTID:48522003 {source="MONDO:equivalentTo", source="DOID:319"} +xref: UMLS:C0037928 {source="MONDO:equivalentTo", source="DOID:319"} +is_a: MONDO:0002602 {source="DOID:319", source="MESH:D013118", source="MONDO:Redundant", source="NCIT:C97110"} ! central nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +relationship: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:319 +property_value: exactMatch http://identifiers.org/mesh/D013118 +property_value: exactMatch http://identifiers.org/snomedct/48522003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037928 +property_value: exactMatch NCIT:C97110 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002546 +name: schwannoma +def: "A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported." [NCIT:C3269] +subset: gard_rare {source="GARD:0004767"} +subset: ordo_disease {source="Orphanet:252164"} +synonym: "benign neurilemmoma" EXACT [MONDO:0004818, NCIT:C3269] +synonym: "benign schwannoma" EXACT [MONDO:0016753, NCIT:C3269] +synonym: "neurilemmoma" EXACT [NCIT:C3269, Orphanet:252164] +synonym: "neurinoma" EXACT [NCIT:C3269] +synonym: "neurolemmoma" RELATED [GARD:0004767] +synonym: "peripheral fibroblastoma" EXACT [Orphanet:252164] +synonym: "psammomatous schwannoma" EXACT [DOID:3192] +synonym: "SCHW" RELATED ABBREVIATION [ONCOTREE:SCHW] +synonym: "schwannoma" EXACT [DOID:3192, NCIT:C3269] +synonym: "schwannoma (WHO grade I)" EXACT [NCIT:C3269] +synonym: "schwannoma, benign" EXACT [NCIT:C3269] +xref: DOID:3192 {source="MONDO:equivalentTo"} +xref: DOID:955 {source="MONDO:equivalentTo"} +xref: EFO:0000693 {source="MONDO:equivalentTo"} +xref: GARD:0004767 {source="MONDO:equivalentTo"} +xref: ICD9:215.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:9560/0 {source="NCIT:C3269"} +xref: MedDRA:10029234 {source="Orphanet:252164", source="Orphanet:252164/e"} +xref: MedDRA:10029235 {source="Orphanet:252164", source="Orphanet:252164/e"} +xref: NCIT:C3269 {source="MONDO:equivalentTo"} +xref: ONCOTREE:SCHW {source="MONDO:equivalentTo"} +xref: Orphanet:252164 {source="MONDO:equivalentTo"} +xref: SCTID:404022001 {source="MONDO:equivalentTo", source="DOID:3192"} +xref: UMLS:C0027809 {source="Orphanet:252164", source="MONDO:equivalentTo", source="Orphanet:252164/e", source="DOID:3192", source="NCIT:C3269"} +xref: UMLS:CN202001 {source="MONDO:equivalentTo"} +is_a: MONDO:0002547 {source="NCIT:C3269", source="ONCOTREE:SCHW"} ! nerve sheath neoplasm +is_a: MONDO:0016752 {source="Orphanet:252164"} ! benign peripheral nerve sheath tumor +is_a: MONDO:0021637 ! low grade glioma +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0002573 ! Schwann cell +relationship: disease_arises_from_structure CL:0002573 ! Schwann cell +relationship: has_modifier MONDO:0024491 {source="NCIT:C3269"} ! tumor grade 1, general grading system +property_value: closeMatch http://identifiers.org/meddra/10029234 +property_value: closeMatch http://identifiers.org/meddra/10029235 +property_value: exactMatch DOID:3192 +property_value: exactMatch DOID:955 +property_value: exactMatch http://identifiers.org/snomedct/404022001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027809 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202001 +property_value: exactMatch NCIT:C3269 +property_value: exactMatch Orphanet:252164 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/4767/schwannoma xsd:anyURI {source="GARD:0004767"} + +[Term] +id: MONDO:0002547 +name: nerve sheath neoplasm +def: "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor." [NCIT:C4972] +synonym: "neoplasm of nerve sheath" EXACT [NCIT:C4972] +synonym: "neoplasm of the nerve sheath" EXACT [DOID:3193, NCIT:C4972] +synonym: "nerve sheath neoplasm" EXACT [NCIT:C4972] +synonym: "nerve sheath tumor" EXACT [NCIT:C4972] +synonym: "nerve sheath tumour" EXACT [DOID:3193] +synonym: "peripheral nerve sheath neoplasm" EXACT [] +synonym: "tumor of nerve sheath" EXACT [NCIT:C4972] +xref: DOID:3193 {source="MONDO:equivalentTo"} +xref: MESH:D018317 {source="MONDO:equivalentTo", source="DOID:3193"} +xref: NCIT:C4972 {source="MONDO:equivalentTo"} +xref: ONCOTREE:NST {source="MONDO:equivalentTo"} +is_a: MONDO:0001406 {source="DOID:3193", source="MESH:D018317", source="ONCOTREE:NST"} ! peripheral nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0002576 ! perineural cell +relationship: disease_arises_from_structure CL:0002576 {source="NCIT:C4972"} ! perineural cell +property_value: exactMatch DOID:3193 +property_value: exactMatch http://identifiers.org/mesh/D018317 +property_value: exactMatch NCIT:C4972 + +[Term] +id: MONDO:0002549 +name: schwannoma of twelfth cranial nerve +def: "A schwannoma that involves the hypoglossal nerve." [MONDO:patterns/location] +synonym: "hypoglossal nerve neurilemmoma" EXACT [NCIT:C5434] +synonym: "hypoglossal nerve schwannoma" EXACT [MONDO:patterns/location, NCIT:C5434] +synonym: "hypoglossal neurilemmoma" EXACT [NCIT:C5434] +synonym: "hypoglossal schwannoma" EXACT [DOID:3197, NCIT:C5434] +synonym: "neurilemmoma of hypoglossal nerve" EXACT [NCIT:C5434] +synonym: "neurilemmoma of the hypoglossal nerve" EXACT [NCIT:C5434] +synonym: "neurilemmoma of the twelfth cranial nerve" EXACT [NCIT:C5434] +synonym: "neurilemmoma of twelfth cranial nerve" EXACT [NCIT:C5434] +synonym: "schwannoma of hypoglossal nerve" EXACT [NCIT:C5434] +synonym: "schwannoma of the hypoglossal nerve" EXACT [NCIT:C5434] +synonym: "schwannoma of the twelfth cranial nerve" EXACT [NCIT:C5434] +synonym: "schwannoma of twelfth cranial nerve" EXACT [NCIT:C5434] +synonym: "twelfth cranial nerve neurilemmoma" EXACT [NCIT:C5434] +synonym: "twelfth cranial nerve schwannoma" EXACT [NCIT:C5434] +xref: DOID:3197 {source="MONDO:equivalentTo"} +xref: NCIT:C5434 {source="MONDO:equivalentTo", source="DOID:3197"} +xref: UMLS:C1335928 {source="MONDO:equivalentTo", source="NCIT:C5434", source="DOID:3197"} +is_a: MONDO:0002546 {source="DOID:3197", source="MONDO:Redundant", source="NCIT:C5434"} ! schwannoma +is_a: MONDO:0002550 {source="DOID:3197", source="MONDO:Redundant", source="NCIT:C5434"} ! hypoglossal nerve neoplasm +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0001650 ! hypoglossal nerve +property_value: exactMatch DOID:3197 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335928 +property_value: exactMatch NCIT:C5434 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002550 +name: hypoglossal nerve neoplasm +def: "A neoplasm involving a hypoglossal nerve." [MONDO:patterns/neoplasm] +synonym: "hypoglossal nerve neoplasm" EXACT [NCIT:C5830] +synonym: "hypoglossal nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "hypoglossal nerve neoplasms" EXACT [NCIT:C5830] +synonym: "hypoglossal nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5830] +synonym: "hypoglossal nerve tumors" EXACT [NCIT:C5830] +synonym: "neoplasm of hypoglossal nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5830] +synonym: "neoplasm of the hypoglossal nerve" EXACT [NCIT:C5830] +synonym: "neoplasm of the twelfth cranial nerve" EXACT [NCIT:C5830] +synonym: "neoplasm of twelfth cranial nerve" EXACT [NCIT:C5830] +synonym: "tumor of hypoglossal nerve" EXACT [DOID:3198, MONDO:patterns/neoplasm, NCIT:C5830] +synonym: "tumor of the hypoglossal nerve" EXACT [NCIT:C5830] +synonym: "tumor of the twelfth cranial nerve" EXACT [NCIT:C5830] +synonym: "tumor of twelfth cranial nerve" EXACT [NCIT:C5830] +synonym: "twelfth cranial nerve neoplasm" EXACT [NCIT:C5830] +synonym: "twelfth cranial nerve neoplasms" EXACT [NCIT:C5830] +synonym: "twelfth cranial nerve tumor" EXACT [NCIT:C5830] +synonym: "twelfth cranial nerve tumors" EXACT [NCIT:C5830] +synonym: "XIIth cranial nerve neoplasms" EXACT [NCIT:C5830] +synonym: "XIIth cranial nerve tumors" EXACT [NCIT:C5830] +xref: DOID:3198 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5830 {source="DOID:3198", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126978008 {source="DOID:3198", source="MONDO:equivalentTo"} +xref: UMLS:C1263903 {source="DOID:3198", source="MONDO:equivalentTo", source="NCIT:C5830"} +is_a: MONDO:0001810 {source="MONDO:Redundant", source="NCIT:C5830"} ! hypoglossal nerve disorder +is_a: MONDO:0002633 {source="DOID:3198", source="MONDO:Redundant", source="NCIT:C5830"} ! cranial nerve neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001650 ! hypoglossal nerve +property_value: exactMatch DOID:3198 +property_value: exactMatch http://identifiers.org/snomedct/126978008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263903 +property_value: exactMatch NCIT:C5830 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002555 +name: trigeminal schwannoma +def: "A schwannoma that involves the trigeminal nerve." [MONDO:patterns/location] +synonym: "fifth cranial nerve neurilemmoma" EXACT [NCIT:C4655] +synonym: "fifth cranial nerve schwannoma" EXACT [NCIT:C4655] +synonym: "neurilemmoma of fifth cranial nerve" EXACT [NCIT:C4655] +synonym: "neurilemmoma of the fifth cranial nerve" EXACT [NCIT:C4655] +synonym: "neurilemmoma of the trigeminal nerve" EXACT [NCIT:C4655] +synonym: "neurilemmoma of trigeminal nerve" EXACT [NCIT:C4655] +synonym: "schwannoma of fifth cranial nerve" EXACT [NCIT:C4655] +synonym: "schwannoma of the fifth cranial nerve" EXACT [NCIT:C4655] +synonym: "schwannoma of the trigeminal nerve" EXACT [NCIT:C4655] +synonym: "schwannoma of trigeminal nerve" EXACT [NCIT:C4655] +synonym: "trigeminal nerve schwannoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "trigeminal neurilemmoma" EXACT [DOID:3202, NCIT:C4655] +synonym: "trigeminal schwannoma" EXACT [NCIT:C4655] +xref: DOID:3202 {source="MONDO:equivalentTo"} +xref: ICD9:215.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4655 {source="DOID:3202", source="MONDO:equivalentTo"} +xref: SCTID:277185000 {source="DOID:3202", source="MONDO:equivalentTo"} +xref: UMLS:C0349582 {source="DOID:3202", source="MONDO:equivalentTo", source="NCIT:C4655"} +is_a: MONDO:0001420 {source="DOID:3202", source="MONDO:Redundant", source="NCIT:C4655"} ! trigeminal nerve neoplasm +is_a: MONDO:0002546 {source="DOID:3202", source="MONDO:Redundant", source="NCIT:C4655"} ! schwannoma +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0001645 ! trigeminal nerve +property_value: exactMatch DOID:3202 +property_value: exactMatch http://identifiers.org/snomedct/277185000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349582 +property_value: exactMatch NCIT:C4655 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002561 +name: lysosomal storage disease +def: "A metabolic disorder caused by mutations in proteins critical for lysosomal function, including lysosomal enzymes, lysosomal integral membrane proteins, and proteins involved in the post-translational modification and trafficking of lysosomal proteins." [PMID:21723623] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68366"} +synonym: "disorder of lysosomal enzyme" EXACT [DOID:3211] +synonym: "disorder of lysosomal enzymes" EXACT [NCIT:C61250] +synonym: "inborn lysosomal enzyme disorder" EXACT [DOID:3211] +synonym: "lysosomal disease" EXACT [MONDO:0019051] +synonym: "lysosomal disorder" EXACT [] +synonym: "lysosomal storage disorder" EXACT [NCIT:C61250] +synonym: "lysosomal storage metabolism disorder" EXACT [DOID:3211] +synonym: "lysosome disease" EXACT [] +synonym: "lysosome disorder" EXACT [] +synonym: "phospholipidosis" RELATED [NCIT:C61250] +xref: DOID:3211 {source="MONDO:equivalentTo"} +xref: MESH:D016464 {source="DOID:3211", source="MONDO:equivalentTo"} +xref: NCIT:C61250 {source="DOID:3211", source="MONDO:equivalentTo"} +xref: Orphanet:68366 {source="MONDO:equivalentTo"} +xref: SCTID:23585005 {source="DOID:3211", source="MONDO:equivalentTo"} +xref: UMLS:C0085078 {source="DOID:3211", source="MONDO:equivalentTo", source="NCIT:C61250"} +xref: UMLS:CN205533 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 {source="DOID:3211", source="MESH:D016464", source="MONDO:Entailed", source="NCIT:C61250", source="Orphanet:68366"} ! inborn errors of metabolism +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005764 ! lysosome +relationship: disease_has_basis_in_dysfunction_of GO:0005764 ! lysosome +property_value: exactMatch DOID:3211 +property_value: exactMatch http://identifiers.org/mesh/D016464 +property_value: exactMatch http://identifiers.org/snomedct/23585005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085078 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN205533 +property_value: exactMatch NCIT:C61250 +property_value: exactMatch Orphanet:68366 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0002562 +name: demyelinating disease +def: "A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others." [NCIT:P378] +synonym: "demyelinating disorder" EXACT [DOID:3213, NCIT:C34527] +xref: DOID:3213 {source="MONDO:equivalentTo"} +xref: MESH:D003711 {source="DOID:3213", source="MONDO:equivalentTo"} +xref: NCIT:C34527 {source="DOID:3213", source="MONDO:equivalentTo"} +xref: UMLS:C0011303 {source="DOID:3213", source="MONDO:equivalentTo", source="NCIT:C34527"} +is_a: MONDO:0005559 {source="DOID:3213", source="MONDO:Redundant", source="NCIT:C34527"} ! neurodegenerative disease +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_disrupts GO:0043217 ! myelin maintenance +relationship: disease_disrupts GO:0043217 ! myelin maintenance +property_value: exactMatch DOID:3213 +property_value: exactMatch http://identifiers.org/mesh/D003711 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011303 +property_value: exactMatch NCIT:C34527 + +[Term] +id: MONDO:0002564 +name: jejunal neoplasm +def: "A benign or malignant neoplasm that affects the wall of the jejunum. Representative examples include adenoma, carcinoma, and lymphoma." [NCIT:P378] +synonym: "jejunal tumor" EXACT [DOID:3218, NCIT:C8401] +synonym: "jejunum neoplasm" EXACT [] +synonym: "jejunum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "jejunum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of jejunum" EXACT [DOID:3218, MONDO:patterns/neoplasm] +synonym: "neoplasm of the jejunum" EXACT [NCIT:C8401] +synonym: "tumor of jejunum" EXACT [DOID:3218, MONDO:patterns/neoplasm] +synonym: "tumor of the jejunum" EXACT [NCIT:C8401] +xref: DOID:3218 {source="MONDO:equivalentTo"} +xref: MESH:D007580 {source="MONDO:equivalentTo", source="DOID:3218"} +xref: NCIT:C8401 {source="MONDO:equivalentTo", source="DOID:3218"} +xref: SCTID:126834003 {source="MONDO:equivalentTo", source="DOID:3218"} +xref: UMLS:C0022374 {source="NCIT:C8401", source="MONDO:equivalentTo", source="DOID:3218"} +is_a: MONDO:0004251 {source="DOID:3218", source="MONDO:Redundant", source="NCIT:C8401"} ! small intestine neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002115 ! jejunum +relationship: disease_has_location UBERON:0002115 ! jejunum +property_value: exactMatch DOID:3218 +property_value: exactMatch http://identifiers.org/mesh/D007580 +property_value: exactMatch http://identifiers.org/snomedct/126834003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022374 +property_value: exactMatch NCIT:C8401 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002565 +name: myelitis +def: "An inflammatory process affecting the spinal cord. Causes include viral infections, autoimmune disorders, vascular disorders, and toxic agents. Symptoms include weakness, paresthesia, sensory loss, pain, and incontinence." [NCIT:P378] +subset: gard_rare {source="GARD:0007130"} +synonym: "inflammation of spinal cord" EXACT [] +synonym: "spinal cord inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:322 {source="MONDO:equivalentTo"} +xref: EFO:1001472 {source="MONDO:equivalentTo"} +xref: GARD:0007130 {source="MONDO:equivalentTo"} +xref: ICD9:323.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009187 {source="MONDO:equivalentTo", source="DOID:322"} +xref: NCIT:C26832 {source="MONDO:equivalentTo", source="DOID:322"} +xref: SCTID:41370002 {source="MONDO:equivalentTo", source="DOID:322"} +xref: UMLS:C0026975 {source="MONDO:equivalentTo", source="NCIT:C26832", source="DOID:322"} +is_a: MONDO:0002545 {source="DOID:322", source="MESH:D009187", source="MONDO:Redundant"} ! spinal cord disorder +is_a: MONDO:0005156 ! encephalomyelitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002240 ! spinal cord +relationship: disease_has_inflammation_site UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:322 +property_value: exactMatch http://identifiers.org/mesh/D009187 +property_value: exactMatch http://identifiers.org/snomedct/41370002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026975 +property_value: exactMatch NCIT:C26832 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7130/myelitis xsd:anyURI {source="GARD:0007130"} + +[Term] +id: MONDO:0002567 +name: tracheal disorder +def: "A non-neoplastic or neoplastic disorder that affects the trachea. Representative examples of non-neoplastic disorders include congenital malformations and infection. Representative examples of neoplastic disorders include carcinoma and lymphoma." [NCIT:P378] +synonym: "disease of trachea" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of trachea" EXACT [] +synonym: "disorder of trachea" EXACT [MONDO:patterns/location_top, NCIT:C35079] +synonym: "trachea disease" EXACT [MONDO:patterns/location] +synonym: "trachea disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "tracheal disorder" EXACT [NCIT:C35079] +xref: DOID:3225 {source="MONDO:equivalentTo"} +xref: MESH:D014133 {source="DOID:3225", source="MONDO:equivalentTo"} +xref: NCIT:C35079 {source="DOID:3225", source="MONDO:equivalentTo"} +xref: SCTID:47125007 {source="DOID:3225", source="MONDO:equivalentTo"} +xref: UMLS:C0040580 {source="DOID:3225", source="MONDO:equivalentTo", source="NCIT:C35079"} +is_a: MONDO:0000270 ! lower respiratory tract disorder +is_a: MONDO:0004867 {source="DOID:3225"} ! upper respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0003126 ! trachea +relationship: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch DOID:3225 +property_value: exactMatch http://identifiers.org/mesh/D014133 +property_value: exactMatch http://identifiers.org/snomedct/47125007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040580 +property_value: exactMatch NCIT:C35079 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002571 +name: primary central nervous system lymphoma +alt_id: MONDO:0018732 +def: "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis." [NCIT:C9301] +subset: ordo_disease {source="Orphanet:46135"} +synonym: "central nervous system lymphoma" EXACT [MONDO:0006129, MONDO:patterns/location, NCIT:C9301] +synonym: "CNS lymphoma" EXACT [NCIT:C9301] +synonym: "lymphoma of central nervous system" EXACT [MONDO:design_pattern] +synonym: "malignant lymphomas of CNS" EXACT [NCIT:C9301] +synonym: "malignant lymphomas of the CNS" EXACT [NCIT:C9301] +synonym: "microglioma" EXACT [DOID:3234, Wikipedia:Primary_central_nervous_system_lymphoma] +synonym: "PCNSL" EXACT ABBREVIATION [NCIT:C9301, Orphanet:46135] +synonym: "primary brain lymphoma" EXACT [Orphanet:46135] +synonym: "primary central nervous system lymphoma" EXACT [NCIT:C9301] +synonym: "primary CNS lymphoma" EXACT [DOID:3234, NCIT:C9301, Orphanet:46135] +synonym: "primary lymphoma, CNS" RELATED [GARD:0009318] +xref: DOID:3234 {source="MONDO:equivalentTo"} +xref: EFO:1000157 {source="MONDO:equivalentTo"} +xref: GARD:0009318 {source="MONDO:equivalentTo"} +xref: ICD10CM:C83.3 {source="Orphanet:46135/ntbt", source="Orphanet:46135"} +xref: ICD9:200.5 {source="DOID:3234"} +xref: MedDRA:10036685 {source="Orphanet:46135/e", source="Orphanet:46135"} +xref: NCIT:C9301 {source="DOID:3234", source="ONCOTREE:PCNSL", source="EFO:1000157", source="MONDO:equivalentTo"} +xref: ONCOTREE:PCNSL {source="MONDO:equivalentTo"} +xref: Orphanet:46135 {source="MONDO:equivalentTo"} +xref: SCTID:307649006 {source="DOID:3234", source="MONDO:equivalentTo", source="MONDO:directSiblingOf"} +xref: UMLS:C0742472 {source="DOID:3234", source="MONDO:equivalentObsolete"} +is_a: MONDO:0000621 ! immune system cancer +is_a: MONDO:0002714 {source="DOID:3234/inferred", source="MONDO:Redundant", source="NCIT:C9301"} ! central nervous system cancer +is_a: MONDO:0003641 {source="DOID:3234", source="MONDO:Redundant", source="NCIT:C9301"} ! central nervous system hematopoietic neoplasm +is_a: MONDO:0004949 {source="ONCOTREE:PCNSL"} ! neoplasm of mature B-cells +is_a: MONDO:0017207 {source="Orphanet:46135"} ! primary organ-specific lymphoma +is_a: MONDO:0017343 {source="Orphanet:46135"} ! Epstein-Barr virus-associated malignant lymphoproliferative disorder +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: closeMatch http://identifiers.org/meddra/10036685 +property_value: exactMatch DOID:3234 +property_value: exactMatch http://identifiers.org/snomedct/307649006 +property_value: exactMatch NCIT:C9301 +property_value: exactMatch Orphanet:46135 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C83.3 + +[Term] +id: MONDO:0002586 +name: thymus cancer +def: "A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites." [NCIT:C4962] +synonym: "cancer of the Thymus" EXACT [NCIT:C4962] +synonym: "cancer of Thymus" EXACT [NCIT:C4962] +synonym: "cancer of thymus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the Thymus" EXACT [NCIT:C4962] +synonym: "malignant neoplasm of Thymus" EXACT [NCIT:C4962] +synonym: "malignant neoplasm of thymus" EXACT [MONDO:patterns/cancer] +synonym: "malignant Thymus neoplasm" EXACT [NCIT:C4962] +synonym: "malignant thymus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant Thymus tumor" EXACT [NCIT:C4962] +synonym: "malignant tumor of the Thymus" EXACT [NCIT:C4962] +synonym: "malignant tumor of Thymus" EXACT [NCIT:C4962] +synonym: "thymic neoplasm" BROAD [DOID:3277] +synonym: "thymic tumor" BROAD [DOID:3277, NCIT:C3412] +synonym: "Thymus cancer" EXACT [NCIT:C4962] +synonym: "thymus cancer" EXACT [MONDO:patterns/location] +xref: DOID:3277 {source="MONDO:equivalentTo"} +xref: ICD9:164.0 {source="DOID:3277", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4962 {source="DOID:3277", source="MONDO:equivalentTo"} +xref: SCTID:363434003 {source="DOID:3277", source="MONDO:equivalentTo"} +xref: UMLS:C0751552 {source="DOID:3277", source="MONDO:equivalentTo", source="NCIT:C4962"} +is_a: MONDO:0000621 ! immune system cancer +is_a: MONDO:0005197 {source="MONDO:Redundant", source="NCIT:C4962"} ! thymus neoplasm +is_a: MONDO:0021069 ! malignant endocrine neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch DOID:3277 +property_value: exactMatch http://identifiers.org/snomedct/363434003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751552 +property_value: exactMatch NCIT:C4962 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002597 +name: notochordal tumor +def: "A bone tumor arising from the remnants of the fetal notochord. This category includes the chordoma and benign notochordal cell tumor." [NCIT:C7063] +synonym: "cancer of notochord" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of notochord" EXACT [MONDO:patterns/cancer] +synonym: "malignant notochord neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of notochord" EXACT [MONDO:patterns/neoplasm] +synonym: "notochord cancer" EXACT [MONDO:patterns/location] +synonym: "notochord neoplasm" EXACT [] +synonym: "notochord tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "notochordal cancer" RELATED [DOID:3303] +synonym: "notochordal neoplasm" EXACT [NCIT:C7063] +synonym: "notochordal tumor" EXACT [DOID:3303, NCIT:C7063] +synonym: "tumor of notochord" EXACT [MONDO:patterns/neoplasm] +xref: DOID:3303 {source="MONDO:equivalentTo"} +xref: NCIT:C7063 {source="MONDO:equivalentTo", source="DOID:3303"} +xref: UMLS:C1335069 {source="MONDO:equivalentTo", source="DOID:3303", source="NCIT:C7063"} +is_a: MONDO:0005564 {source="NCIT:C7063"} ! embryonal neoplasm +is_a: MONDO:0019060 {source="NCIT:C7063"} ! bone neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002328 ! notochord +relationship: disease_has_location UBERON:0002328 ! notochord +property_value: exactMatch DOID:3303 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335069 +property_value: exactMatch NCIT:C7063 +property_value: excluded_subClassOf MONDO:0002129 {source="DOID:3303"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002602 +name: central nervous system disorder +def: "A disease involving the central nervous system." [https://orcid.org/0000-0002-6601-2165] +synonym: "central nervous disease" EXACT [DOID:331] +synonym: "central nervous system disease" EXACT [MONDO:patterns/location, NCIT:C2934] +synonym: "central nervous system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "central nervous system disorder" EXACT [NCIT:C2934] +synonym: "CNS disorder" EXACT [https://orcid.org/0000-0001-5208-3432] +synonym: "disease of central nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease of the central nervous system" EXACT [ISBN-13:978-1-259-64403-0] +synonym: "disease or disorder of central nervous system" EXACT [] +synonym: "disorder of central nervous system" EXACT [MONDO:patterns/location_top, NCIT:C2934] +xref: DOID:331 {source="MONDO:equivalentTo"} +xref: MESH:D002493 {source="MONDO:equivalentTo", source="DOID:331"} +xref: NCIT:C2934 {source="MONDO:equivalentTo", source="DOID:331"} +xref: SCTID:23853001 {source="MONDO:equivalentTo", source="DOID:331"} +xref: UMLS:C0007682 {source="NCIT:C2934", source="MONDO:equivalentTo", source="DOID:331"} +is_a: MONDO:0005071 {source="DOID:331", source="MESH:D002493", source="MONDO:Redundant", source="NCIT:C2934"} ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +relationship: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:331 +property_value: exactMatch http://identifiers.org/mesh/D002493 +property_value: exactMatch http://identifiers.org/snomedct/23853001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007682 +property_value: exactMatch NCIT:C2934 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002604 +name: pericytic neoplasm +def: "A benign or malignant mesenchymal neoplasm arising from the perivascular cells of the connective and soft tissues. It is characterized by the presence of pericytes that grow in a circumferential pattern around vessels." [NCIT:C6528] +synonym: "malignant perivascular cancer" NARROW [DOID:3316] +synonym: "Pericytic neoplasm" EXACT [NCIT:C6528] +synonym: "Pericytic tumor" EXACT [NCIT:C6528] +synonym: "perivascular neoplasm" EXACT [NCIT:C6528] +synonym: "perivascular tumor" EXACT [NCIT:C6528] +xref: DOID:3316 {source="MONDO:equivalentTo"} +xref: NCIT:C6528 {source="MONDO:equivalentTo", source="DOID:3316"} +xref: UMLS:C1335392 {source="MONDO:equivalentTo", source="DOID:3316", source="NCIT:C6528"} +is_a: MONDO:0002616 {source="MONDO:Redundant", source="NCIT:C6528"} ! mesenchymal cell neoplasm +intersection_of: MONDO:0002616 {source="NCIT:C6528"} ! mesenchymal cell neoplasm +intersection_of: disease_arises_from_structure CL:0000669 {source="NCIT:C6528"} ! pericyte cell +relationship: disease_arises_from_structure CL:0000669 ! pericyte cell +property_value: exactMatch DOID:3316 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335392 +property_value: exactMatch NCIT:C6528 + +[Term] +id: MONDO:0002612 +name: frontal lobe epilepsy +def: "A localization-related (focal) form of epilepsy characterized by seizures which arise in the frontal lobe. A variety of clinical syndromes exist depending on the exact location of the seizure focus. Frontal lobe seizures may be idiopathic (cryptogenic) or caused by an identifiable disease process such as traumatic injuries, neoplasms, or other macroscopic or microscopic lesions of the frontal lobes (symptomatic frontal lobe seizures). (From Adams et al., Principles of Neurology, 6th ed, pp318-9)" [MESH:D017034] +synonym: "epilepsy of frontal lobe" EXACT [MONDO:design_pattern] +synonym: "frontal lobe epilepsy" EXACT [MONDO:patterns/location] +xref: DOID:3331 {source="MONDO:equivalentTo"} +xref: MESH:D017034 {source="DOID:3331", source="MONDO:equivalentTo"} +xref: SCTID:230394006 {source="DOID:3331", source="MONDO:equivalentTo"} +xref: UMLS:C0085541 {source="DOID:3331", source="MONDO:equivalentTo"} +is_a: MONDO:0005384 {source="DOID:3331", source="MESH:D017034"} ! partial epilepsy +intersection_of: MONDO:0005027 ! epilepsy +intersection_of: disease_has_location UBERON:0016525 ! frontal lobe +relationship: disease_has_location UBERON:0016525 ! frontal lobe +property_value: exactMatch DOID:3331 +property_value: exactMatch http://identifiers.org/mesh/D017034 +property_value: exactMatch http://identifiers.org/snomedct/230394006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085541 + +[Term] +id: MONDO:0002614 +name: bone inflammation disease +def: "Inflammation of the bone." [MESH:D010000] +synonym: "bone inflammatory disease" EXACT [DOID:3342] +synonym: "inflammatory disorder of bone" EXACT [DOID:3342] +synonym: "osteitis" EXACT [DOID:3342] +xref: DOID:3342 {source="MONDO:equivalentTo"} +xref: MESH:D010000 {source="DOID:3342", source="MONDO:equivalentTo"} +xref: SCTID:274144001 {source="DOID:3342", source="MONDO:equivalentTo"} +xref: UMLS:C0029400 {source="DOID:3342", source="MONDO:equivalentTo"} +is_a: MONDO:0005381 {source="DOID:3342", source="MESH:D010000"} ! bone disorder +property_value: exactMatch DOID:3342 +property_value: exactMatch http://identifiers.org/mesh/D010000 +property_value: exactMatch http://identifiers.org/snomedct/274144001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029400 + +[Term] +id: MONDO:0002616 +name: mesenchymal cell neoplasm +def: "A benign, intermediate, or malignant neoplasm that arises from the mesenchyma-derived cells of the soft tissue or bone. Representative examples include lipoma, leiomyoma, leiomyosarcoma and osteosarcoma." [NCIT:C7059] +synonym: "benign miscellaneous mesenchymal tumor" EXACT [DOID:3350] +synonym: "mesenchymal cell neoplasm" EXACT [NCIT:C7059] +synonym: "mesenchymal cell tumor" EXACT [NCIT:C7059] +synonym: "mesenchymal neoplasm" EXACT [NCIT:C7059] +synonym: "mesenchymal tumor" EXACT [DOID:3350, NCIT:C7059] +xref: DOID:3350 {source="MONDO:equivalentTo"} +xref: NCIT:C7059 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3350"} +xref: UMLS:C1334699 {source="NCIT:C7059", source="MONDO:equivalentTo", source="DOID:3350"} +is_a: MONDO:0005070 {source="DOID:3350/inferred", source="MONDO:Redundant", source="NCIT:C7059/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0008019 ! mesenchymal cell +relationship: disease_arises_from_structure CL:0008019 ! mesenchymal cell +property_value: exactMatch DOID:3350 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334699 +property_value: exactMatch NCIT:C7059 + +[Term] +id: MONDO:0002633 +name: cranial nerve neoplasm +def: "Abnormal growth of the cells that comprise the cranial nerves." [NCIT:C2963] +synonym: "cranial nerve neoplasm" EXACT [NCIT:C2963] +synonym: "cranial nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "cranial nerve neoplasms" EXACT [NCIT:C2963] +synonym: "cranial nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2963] +synonym: "neoplasm of cranial nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C2963] +synonym: "neoplasm of the cranial nerve" EXACT [NCIT:C2963] +synonym: "tumor of cranial nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C2963] +synonym: "tumor of the cranial nerve" EXACT [DOID:338, NCIT:C2963] +xref: DOID:338 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003390 {source="DOID:338", source="MONDO:equivalentTo"} +xref: NCIT:C2963 {source="DOID:338", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126966009 {source="DOID:338", source="MONDO:equivalentTo"} +xref: UMLS:C0010267 {source="DOID:338", source="MONDO:equivalentTo", source="NCIT:C2963"} +is_a: MONDO:0001406 {source="MESH:D003390", source="MONDO:Redundant"} ! peripheral nervous system neoplasm +is_a: MONDO:0003569 {source="MESH:D003390", source="MONDO:Redundant", source="NCIT:C2963"} ! cranial nerve neuropathy +is_a: MONDO:0005586 ! head and neck neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001785 ! cranial nerve +relationship: disease_has_location UBERON:0001785 ! cranial nerve +property_value: exactMatch DOID:338 +property_value: exactMatch http://identifiers.org/mesh/D003390 +property_value: exactMatch http://identifiers.org/snomedct/126966009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010267 +property_value: exactMatch NCIT:C2963 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002635 +name: periodontal disorder +def: "An inflammatory process of the gingival tissues and/or periodontal membrane of the teeth, resulting in an abnormally deep gingival sulcus, possibly producing periodontal pockets and loss of alveolar bone support." [NCIT:P378] +synonym: "disease of periodontium" EXACT [MONDO:patterns/location_top] +synonym: "disease of supporting structures of teeth" EXACT [DOID:3388] +synonym: "disease or disorder of periodontium" EXACT [] +synonym: "disorder of periodontium" EXACT [MONDO:patterns/location_top] +synonym: "periodontal disease" EXACT [DOID:3388] +synonym: "periodontal disorder" EXACT [NCIT:C63743] +synonym: "periodontium disease" EXACT [MONDO:patterns/location] +synonym: "periodontium disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "periodontium disorder" EXACT [DOID:3388] +xref: DOID:3388 {source="MONDO:equivalentTo"} +xref: ICD9:523.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010510 {source="DOID:3388", source="MONDO:equivalentTo"} +xref: NCIT:C63743 {source="DOID:3388", source="MONDO:equivalentTo"} +xref: SCTID:2556008 {source="DOID:3388", source="MONDO:equivalentTo"} +xref: UMLS:C0031090 {source="DOID:3388", source="MONDO:equivalentTo", source="NCIT:C63743"} +is_a: MONDO:0006999 {source="DOID:3388", source="NCIT:C63743/inferred"} ! tooth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001758 ! periodontium +relationship: disease_has_location UBERON:0001758 ! periodontium +property_value: exactMatch DOID:3388 +property_value: exactMatch http://identifiers.org/mesh/D010510 +property_value: exactMatch http://identifiers.org/snomedct/2556008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031090 +property_value: exactMatch NCIT:C63743 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002636 +name: accessory nerve disorder +def: "A disease involving the accessory XI nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "accessory nerve disorder" EXACT [NCIT:C26953] +synonym: "accessory XI nerve disease" EXACT [MONDO:patterns/location] +synonym: "accessory XI nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of accessory XI nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of accessory XI nerve" EXACT [] +synonym: "disorder of 11th nerve" EXACT [DOID:339, NCIT:C26953] +synonym: "disorder of accessory [11th] nerve" EXACT [DOID:339, ICD9CM:352.4] +synonym: "disorder of accessory nerve" EXACT [DOID:339] +synonym: "disorder of accessory XI nerve" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the 11th nerve" EXACT [NCIT:C26953] +synonym: "eleventh nerve disorder" EXACT [DOID:339, NCIT:C26953] +xref: DOID:339 {source="MONDO:equivalentTo"} +xref: ICD9:352.4 {source="DOID:339", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D020436 {source="DOID:339", source="MONDO:equivalentTo"} +xref: NCIT:C26953 {source="DOID:339", source="MONDO:equivalentTo"} +xref: SCTID:84759007 {source="DOID:339", source="MONDO:equivalentTo"} +xref: UMLS:C0152180 {source="DOID:339", source="MONDO:equivalentTo", source="NCIT:C26953"} +is_a: MONDO:0003569 {source="DOID:339/inferred", source="MESH:D020436", source="MONDO:Redundant", source="NCIT:C26953"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002019 ! accessory XI nerve +relationship: disease_has_location UBERON:0002019 ! accessory XI nerve +property_value: exactMatch DOID:339 +property_value: exactMatch http://identifiers.org/mesh/D020436 +property_value: exactMatch http://identifiers.org/snomedct/84759007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152180 +property_value: exactMatch NCIT:C26953 +property_value: excluded_subClassOf MONDO:0002639 {source="DOID:339"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002638 +name: glossopharyngeal nerve neoplasm +def: "A neoplasm involving a glossopharyngeal nerve." [MONDO:patterns/neoplasm] +synonym: "glossopharyngeal nerve neoplasm" EXACT [NCIT:C5828] +synonym: "glossopharyngeal nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "glossopharyngeal nerve neoplasms" EXACT [NCIT:C5828] +synonym: "glossopharyngeal nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5828] +synonym: "glossopharyngeal nerve tumors" EXACT [NCIT:C5828] +synonym: "IXth cranial nerve neoplasms" EXACT [NCIT:C5828] +synonym: "IXth cranial nerve tumors" EXACT [NCIT:C5828] +synonym: "neoplasm of glossopharyngeal nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5828] +synonym: "neoplasm of Ninth cranial nerve" EXACT [NCIT:C5828] +synonym: "neoplasm of the glossopharyngeal nerve" EXACT [NCIT:C5828] +synonym: "neoplasm of the Ninth cranial nerve" EXACT [NCIT:C5828] +synonym: "Ninth cranial nerve neoplasm" EXACT [NCIT:C5828] +synonym: "Ninth cranial nerve neoplasms" EXACT [NCIT:C5828] +synonym: "Ninth cranial nerve tumor" EXACT [NCIT:C5828] +synonym: "Ninth cranial nerve tumors" EXACT [NCIT:C5828] +synonym: "tumor of glossopharyngeal nerve" EXACT [DOID:3417, MONDO:patterns/neoplasm, NCIT:C5828] +synonym: "tumor of Ninth cranial nerve" EXACT [NCIT:C5828] +synonym: "tumor of the glossopharyngeal nerve" EXACT [NCIT:C5828] +synonym: "tumor of the Ninth cranial nerve" EXACT [NCIT:C5828] +xref: DOID:3417 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5828 {source="MONDO:equivalentTo", source="DOID:3417", source="MONDO:exact-label-match"} +xref: SCTID:126975006 {source="MONDO:equivalentTo", source="DOID:3417"} +xref: UMLS:C1263900 {source="NCIT:C5828", source="MONDO:equivalentTo", source="DOID:3417"} +is_a: MONDO:0002633 {source="DOID:3417", source="MONDO:Redundant", source="NCIT:C5828"} ! cranial nerve neoplasm +is_a: MONDO:0002639 ! glossopharyngeal nerve disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001649 ! glossopharyngeal nerve +property_value: exactMatch DOID:3417 +property_value: exactMatch http://identifiers.org/snomedct/126975006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263900 +property_value: exactMatch NCIT:C5828 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002639 +name: glossopharyngeal nerve disorder +def: "A disease involving the glossopharyngeal nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of glossopharyngeal nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of glossopharyngeal nerve" EXACT [] +synonym: "disorder of glossopharyngeal nerve" EXACT [MONDO:patterns/location_top] +synonym: "glossopharyngeal nerve disease" EXACT [MONDO:patterns/location] +synonym: "glossopharyngeal nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "glossopharyngeal nerve disorder" EXACT [NCIT:C27211] +synonym: "IX nerve disorder" EXACT [NCIT:C27211] +synonym: "ninth nerve disorder" EXACT [NCIT:C27211] +xref: DOID:3418 {source="MONDO:equivalentTo"} +xref: ICD9:352 {source="DOID:3418"} +xref: ICD9:352.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27211 {source="MONDO:equivalentTo"} +xref: SCTID:80962007 {source="MONDO:equivalentTo"} +xref: UMLS:C0751941 {source="MONDO:equivalentTo"} +is_a: MONDO:0003569 {source="DOID:3418", source="MONDO:Redundant", source="NCIT:C27211"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001649 ! glossopharyngeal nerve +relationship: disease_has_location UBERON:0001649 ! glossopharyngeal nerve +property_value: exactMatch DOID:3418 +property_value: exactMatch http://identifiers.org/snomedct/80962007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751941 +property_value: exactMatch NCIT:C27211 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002640 +name: optic nerve neoplasm +def: "Benign and malignant neoplasms which arise from or metastasize to the optic or second cranial nerve which extends from the optic disc of the eye and joins the optic chiasm. Clinical features may include visual loss, proptosis, and local pain. The majority of optic nerve tumors or optic gliomas." [NCIT:C4801] +synonym: "cranial nerve II neoplasm" EXACT [] +synonym: "cranial nerve II neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "cranial nerve II neoplasms" EXACT [NCIT:C4801] +synonym: "cranial nerve II tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of cranial nerve II" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of optic nerve" EXACT [NCIT:C4801] +synonym: "neoplasm of second cranial nerve" EXACT [NCIT:C4801] +synonym: "neoplasm of the optic nerve" EXACT [NCIT:C4801] +synonym: "neoplasm of the second cranial nerve" EXACT [NCIT:C4801] +synonym: "neoplasms, optic nerve" EXACT [NCIT:C4801] +synonym: "neoplasms, second cranial nerve" EXACT [NCIT:C4801] +synonym: "optic nerve neoplasm" EXACT [NCIT:C4801] +synonym: "optic nerve neoplasms" EXACT [NCIT:C4801] +synonym: "optic nerve tumor" EXACT [NCIT:C4801] +synonym: "second cranial nerve neoplasm" EXACT [NCIT:C4801] +synonym: "second cranial nerve neoplasms" EXACT [NCIT:C4801] +synonym: "second cranial nerve tumor" EXACT [NCIT:C4801] +synonym: "tumor of cranial nerve II" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of optic nerve" EXACT [NCIT:C4801] +synonym: "tumor of second cranial nerve" EXACT [DOID:3419, NCIT:C4801] +synonym: "tumor of the optic nerve" EXACT [NCIT:C4801] +synonym: "tumor of the second cranial nerve" EXACT [NCIT:C4801] +synonym: "tumour of optic nerve" EXACT [DOID:3419] +xref: DOID:3419 {source="MONDO:equivalentTo"} +xref: EFO:1001073 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D019574 {source="MONDO:equivalentTo", source="DOID:3419"} +xref: NCIT:C4801 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3419"} +xref: SCTID:395505000 {source="MONDO:equivalentTo", source="DOID:3419"} +xref: UMLS:C0524802 {source="MONDO:equivalentTo", source="NCIT:C4801", source="DOID:3419"} +is_a: MONDO:0002135 {source="MESH:D019574", source="MONDO:Redundant", source="NCIT:C4801"} ! optic nerve disorder +is_a: MONDO:0002633 {source="DOID:3419", source="MESH:D019574", source="NCIT:C4801"} ! cranial nerve neoplasm +is_a: MONDO:0006130 ! central nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000941 ! cranial nerve II +property_value: exactMatch DOID:3419 +property_value: exactMatch http://identifiers.org/mesh/D019574 +property_value: exactMatch http://identifiers.org/snomedct/395505000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0524802 +property_value: exactMatch NCIT:C4801 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002642 +name: trochlear nerve neoplasm +def: "A neoplasm involving a trochlear nerve." [MONDO:patterns/neoplasm] +synonym: "fourth cranial nerve neoplasm" EXACT [NCIT:C5825] +synonym: "fourth cranial nerve neoplasms" EXACT [NCIT:C5825] +synonym: "fourth cranial nerve tumor" EXACT [NCIT:C5825] +synonym: "fourth cranial nerve tumors" EXACT [NCIT:C5825] +synonym: "IVth cranial nerve neoplasms" EXACT [NCIT:C5825] +synonym: "IVth cranial nerve tumors" EXACT [NCIT:C5825] +synonym: "neoplasm of fourth cranial nerve" EXACT [NCIT:C5825] +synonym: "neoplasm of the fourth cranial nerve" EXACT [NCIT:C5825] +synonym: "neoplasm of the trochlear nerve" EXACT [NCIT:C5825] +synonym: "neoplasm of trochlear nerve" EXACT [MONDO:patterns/neoplasm] +synonym: "trochlear nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "trochlear nerve neoplasms" EXACT [NCIT:C5825] +synonym: "trochlear nerve tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "trochlear nerve tumors" EXACT [NCIT:C5825] +synonym: "tumor of fourth cranial nerve" EXACT [NCIT:C5825] +synonym: "tumor of the fourth cranial nerve" EXACT [NCIT:C5825] +synonym: "tumor of the trochlear nerve" EXACT [NCIT:C5825] +synonym: "tumor of trochlear nerve" EXACT [DOID:3421, MONDO:patterns/neoplasm, NCIT:C5825] +xref: DOID:3421 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5825 {source="DOID:3421", source="MONDO:equivalentTo"} +xref: SCTID:126970001 {source="DOID:3421", source="MONDO:equivalentTo"} +xref: UMLS:C1263896 {source="DOID:3421", source="MONDO:equivalentTo", source="NCIT:C5825"} +is_a: MONDO:0002633 {source="DOID:3421", source="MONDO:Redundant", source="NCIT:C5825"} ! cranial nerve neoplasm +is_a: MONDO:0007002 {source="MONDO:Redundant", source="NCIT:C5825"} ! trochlear nerve disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001644 ! trochlear nerve +property_value: exactMatch DOID:3421 +property_value: exactMatch http://identifiers.org/snomedct/126970001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263896 +property_value: exactMatch NCIT:C5825 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002643 +name: vestibular disorder +def: "Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls." [MESH:D015837] +synonym: "disease of vestibular labyrinth" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease of vestibular system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vestibular labyrinth" EXACT [] +synonym: "disorder of vestibular labyrinth" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disorder of vestibular system" RELATED [MONDO:patterns/location_top] +synonym: "vertigo, vestibular disorder" EXACT [DOID:3426] +synonym: "vestibular labyrinth disease" EXACT [MONDO:design_pattern] +synonym: "vestibular labyrinth disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vestibular system disease" EXACT [MONDO:patterns/location] +xref: DOID:3426 {source="MONDO:equivalentTo"} +xref: MESH:D015837 {source="MONDO:equivalentTo", source="DOID:3426"} +xref: UMLS:C0042594 {source="MONDO:equivalentTo", source="DOID:3426"} +is_a: MONDO:0002467 {source="DOID:3426", source="MESH:D015837", source="MONDO:Redundant"} ! inner ear disorder +is_a: MONDO:0019056 ! neuromuscular disease +is_a: MONDO:0024417 ! perceptual disorders +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001862 ! vestibular labyrinth +relationship: disease_disrupts GO:0050957 ! equilibrioception +relationship: disease_has_location UBERON:0001862 ! vestibular labyrinth +property_value: exactMatch DOID:3426 +property_value: exactMatch http://identifiers.org/mesh/D015837 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042594 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002645 +name: cerebritis +def: "Inflammation of the cerebrum." [NCIT:P378] +synonym: "cerebral hemisphere inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of cerebral hemisphere" EXACT [] +xref: DOID:3431 {source="MONDO:equivalentTo"} +xref: NCIT:C27199 {source="DOID:3431", source="MONDO:equivalentTo"} +xref: UMLS:C0742115 {source="DOID:3431", source="NCIT:C27199", source="MONDO:equivalentTo"} +is_a: MONDO:0015144 ! brain inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001869 ! cerebral hemisphere +relationship: disease_has_inflammation_site UBERON:0001869 ! cerebral hemisphere +property_value: exactMatch DOID:3431 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0742115 +property_value: exactMatch NCIT:C27199 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002646 +name: viral laryngitis +def: "Acute inflammation of the larynx caused by viruses, including rhinovirus, influenza virus, parainfluenza virus, and adenovirus." [NCIT:P378] +synonym: "Viruses caused laryngitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses laryngitis" EXACT [] +xref: DOID:3436 {source="MONDO:equivalentTo"} +xref: ICD9:464.00 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27305 {source="DOID:3436", source="MONDO:equivalentTo"} +xref: SCTID:441551009 {source="DOID:3436", source="MONDO:equivalentTo"} +xref: UMLS:C0853195 {source="DOID:3436", source="MONDO:equivalentTo", source="NCIT:C27305"} +is_a: MONDO:0004777 {source="DOID:3436"} ! acute laryngitis +is_a: MONDO:0024355 ! respiratory tract infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0001737 ! larynx +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch DOID:3436 +property_value: exactMatch http://identifiers.org/snomedct/441551009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0853195 +property_value: exactMatch NCIT:C27305 + +[Term] +id: MONDO:0002647 +name: laryngitis +def: "An acute or chronic, bacterial or viral inflammatory process affecting the larynx. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness." [NCIT:P378] +synonym: "inflammation of larynx" EXACT [] +synonym: "laryngeal Inflammation" EXACT [NCIT:C26811] +synonym: "laryngeal inflammation" EXACT [NCIT:C26811] +synonym: "larynx inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:3437 {source="MONDO:equivalentTo"} +xref: ICD9:464.00 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007827 {source="MONDO:equivalentTo", source="DOID:3437"} +xref: NCIT:C26811 {source="MONDO:equivalentTo", source="DOID:3437"} +xref: SCTID:45913009 {source="MONDO:equivalentTo", source="DOID:3437"} +xref: UMLS:C0023067 {source="MONDO:equivalentTo", source="DOID:3437", source="NCIT:C26811"} +is_a: MONDO:0004382 {source="DOID:3437", source="MESH:D007827", source="MONDO:Redundant", source="NCIT:C26811/inferred"} ! laryngeal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001737 ! larynx +relationship: disease_has_feature HP:0001609 ! Hoarse voice +relationship: disease_has_feature HP:0001686 ! Loss of voice +relationship: disease_has_inflammation_site UBERON:0001737 ! larynx +property_value: exactMatch DOID:3437 +property_value: exactMatch http://identifiers.org/mesh/D007827 +property_value: exactMatch http://identifiers.org/snomedct/45913009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023067 +property_value: exactMatch NCIT:C26811 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002650 +name: scrotal carcinoma +def: "A carcinoma that arises from epithelial cells of the scrotum." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of scrotum" BROAD [NCIT:C6389] +synonym: "cancer of the scrotum" BROAD [NCIT:C6389] +synonym: "carcinoma of scrotum" EXACT [DOID:3445, MONDO:patterns/carcinoma, NCIT:C6389] +synonym: "carcinoma of the scrotum" EXACT [NCIT:C6389] +synonym: "scrotal cancer" BROAD [NCIT:C6389] +synonym: "scrotum carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3445 {source="MONDO:equivalentTo"} +xref: NCIT:C6389 {source="DOID:3445", source="MONDO:equivalentTo"} +xref: UMLS:C1370468 {source="DOID:3445", source="MONDO:equivalentTo", source="NCIT:C6389"} +is_a: MONDO:0004993 {source="DOID:3445", source="MONDO:Redundant", source="NCIT:C6389/inferred"} ! carcinoma +is_a: MONDO:0021112 {source="MONDO:Redundant", source="NCIT:C6389"} ! scrotum cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch DOID:3445 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1370468 +property_value: exactMatch NCIT:C6389 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002652 +name: anus adenocarcinoma +def: "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis." [NCIT:C5600] +synonym: "adenocarcinoma of anus" EXACT [DOID:3447, NCIT:C5600] +synonym: "adenocarcinoma of the anus" EXACT [DOID:3447, NCIT:C5600] +synonym: "anal adenocarcinoma" EXACT [NCIT:C5600] +synonym: "anus adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3447 {source="MONDO:equivalentTo"} +xref: NCIT:C5600 {source="DOID:3447", source="MONDO:equivalentTo"} +xref: SCTID:423607006 {source="DOID:3447", source="MONDO:equivalentTo"} +xref: UMLS:C1332257 {source="DOID:3447", source="MONDO:equivalentTo", source="NCIT:C5600"} +is_a: MONDO:0002169 ! rectum adenocarcinoma +is_a: MONDO:0003199 {source="DOID:3447", source="MONDO:Redundant", source="NCIT:C5600"} ! anal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:3447 +property_value: exactMatch http://identifiers.org/snomedct/423607006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332257 +property_value: exactMatch NCIT:C5600 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002654 +name: uterine disorder +def: "A non-neoplastic or neoplastic disorder that affects the uterine corpus or the cervix. Representative examples of non-neoplastic disorders include endometritis and cervicitis. Representative examples of neoplastic disorders include endometrial carcinoma, carcinosarcoma, and cervical carcinoma." [NCIT:P378] +synonym: "disease of uterus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of uterus" EXACT [] +synonym: "disorder of uterus" EXACT [MONDO:patterns/location_top] +synonym: "uterine disease" EXACT [NCIT:C26907] +synonym: "uterine disorder" EXACT [NCIT:C26907] +synonym: "uterus disease" EXACT [MONDO:patterns/location] +synonym: "uterus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:345 {source="MONDO:equivalentTo"} +xref: ICD9:621.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:621.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:345"} +xref: MESH:D014591 {source="MONDO:equivalentTo", source="DOID:345"} +xref: NCIT:C26907 {source="MONDO:equivalentTo", source="DOID:345"} +xref: SCTID:12337004 {source="MONDO:equivalentTo", source="DOID:345"} +xref: UMLS:C0042131 {source="NCIT:C26907", source="MONDO:equivalentTo", source="DOID:345"} +is_a: MONDO:0002263 {source="DOID:345", source="MESH:D014591", source="MONDO:Redundant", source="NCIT:C26907"} ! female reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000995 ! uterus +relationship: disease_has_location UBERON:0000995 ! uterus +property_value: exactMatch DOID:345 +property_value: exactMatch http://identifiers.org/mesh/D014591 +property_value: exactMatch http://identifiers.org/snomedct/12337004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042131 +property_value: exactMatch NCIT:C26907 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002656 +name: skin carcinoma +def: "A carcinoma that arises from epithelial cells of the zone of skin" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of skin" EXACT [DOID:3451, MTH:683, NCIT:C4914] +synonym: "carcinoma of the skin" EXACT [NCIT:C4914] +synonym: "carcinoma of zone of skin" EXACT [MONDO:patterns/carcinoma] +synonym: "non-melanoma cancer of skin" EXACT [NCIT:C4914] +synonym: "non-melanoma cancer of the skin" EXACT [NCIT:C4914] +synonym: "non-melanoma skin cancer" EXACT [NCIT:C4914] +synonym: "nonmelanoma skin cancer" EXACT [NCIT:C4914] +synonym: "skin cancer, non-melanoma" EXACT [NCIT:C4914] +synonym: "skin carcinoma" EXACT [NCIT:C4914] +synonym: "zone of skin carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3451 {source="MONDO:equivalentTo"} +xref: NCIT:C4914 {source="DOID:3451", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0699893 {source="DOID:3451", source="NCIT:C4914", source="MONDO:equivalentTo"} +is_a: MONDO:0002898 {source="DOID:3451", source="MONDO:Redundant", source="NCIT:C4914"} ! skin cancer +is_a: MONDO:0004993 {source="DOID:3451", source="MONDO:Redundant", source="NCIT:C4914"} ! carcinoma +is_a: MONDO:0021634 {source="MONDO:Redundant", source="NCIT:C4914"} ! epithelial skin neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:3451 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0699893 +property_value: exactMatch NCIT:C4914 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002657 +name: breast disorder +def: "A disease involving the breast." [https://orcid.org/0000-0002-6601-2165] +synonym: "breast disease" EXACT [MONDO:patterns/location, NCIT:C26709] +synonym: "breast disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "breast diseases" EXACT [NCIT:C26709] +synonym: "breast disorder" EXACT [NCIT:C26709] +synonym: "disease of breast" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of breast" EXACT [] +synonym: "disorder of breast" EXACT [MONDO:patterns/location_top] +xref: DOID:3463 {source="MONDO:equivalentTo"} +xref: ICD10CM:N60-N65 {source="DOID:3463", source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:610-612.99 {source="DOID:3463"} +xref: ICD9:611.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:611.9 {source="DOID:3463", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001941 {source="DOID:3463", source="MONDO:equivalentTo"} +xref: NCIT:C26709 {source="DOID:3463", source="MONDO:equivalentTo"} +xref: SCTID:79604008 {source="DOID:3463", source="MONDO:equivalentTo"} +xref: UMLS:C0006145 {source="DOID:3463", source="NCIT:C26709", source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000310 ! breast +relationship: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:3463 +property_value: exactMatch http://identifiers.org/mesh/D001941 +property_value: exactMatch http://identifiers.org/snomedct/79604008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006145 +property_value: exactMatch https://icd.codes/icd10cm/N60-N65 +property_value: exactMatch NCIT:C26709 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002658 +name: iris cancer +def: "A malignant neoplasm involving the iris." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of iris" EXACT [MONDO:patterns/cancer] +synonym: "iris cancer" EXACT [MONDO:patterns/location] +synonym: "malignant iris neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant iris tumor" EXACT [NCIT:C4554] +synonym: "malignant neoplasm of iris" EXACT [MONDO:patterns/cancer, NCIT:C4554] +synonym: "malignant neoplasm of the iris" EXACT [DOID:3478, NCIT:C4554] +synonym: "malignant tumor of iris" EXACT [DOID:3478] +synonym: "malignant tumor of the iris" EXACT [NCIT:C4554] +synonym: "tumor of the iris" BROAD [DOID:3478, NCIT:C3142] +xref: DOID:3478 {source="MONDO:equivalentTo"} +xref: EFO:1000996 {source="MONDO:equivalentTo"} +xref: NCIT:C4554 {source="DOID:3478", source="MONDO:equivalentTo"} +xref: SCTID:188264002 {source="DOID:3478", source="MONDO:equivalentTo"} +xref: UMLS:C0346372 {source="DOID:3478", source="MONDO:equivalentTo", source="NCIT:C4554"} +is_a: MONDO:0002659 {source="DOID:3478", source="MONDO:Redundant", source="NCIT:C4554"} ! uveal cancer +is_a: MONDO:0021224 {source="MONDO:Redundant", source="NCIT:C4554"} ! iris neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001769 ! iris +property_value: exactMatch DOID:3478 +property_value: exactMatch http://identifiers.org/snomedct/188264002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346372 +property_value: exactMatch NCIT:C4554 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002659 +name: uveal cancer +def: "A primary or metastatic malignant neoplasm that affects the choroid, ciliary body, or iris." [NCIT:P378] +synonym: "cancer of uvea" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the uvea" EXACT [NCIT:C6105] +synonym: "malignant neoplasm of uvea" EXACT [MONDO:patterns/cancer, NCIT:C6105] +synonym: "malignant tumor of the uvea" EXACT [NCIT:C6105] +synonym: "malignant tumor of uvea" EXACT [NCIT:C6105] +synonym: "malignant uvea neoplasm" EXACT [DOID:3479, MONDO:patterns/cancer, NCIT:C6105] +synonym: "malignant uvea tumor" EXACT [NCIT:C6105] +synonym: "malignant uveal neoplasm" EXACT [NCIT:C6105] +synonym: "malignant uveal tumor" EXACT [DOID:3479, NCIT:C6105] +synonym: "uvea cancer" EXACT [MONDO:patterns/location] +synonym: "uveal tumor" BROAD [DOID:3479, NCIT:C3436] +xref: DOID:3479 {source="MONDO:equivalentTo"} +xref: EFO:1001230 {source="MONDO:equivalentTo"} +xref: NCIT:C6105 {source="MONDO:equivalentTo", source="DOID:3479"} +xref: UMLS:C1334629 {source="MONDO:equivalentTo", source="DOID:3479", source="NCIT:C6105"} +is_a: MONDO:0002236 {source="DOID:3479", source="MONDO:Redundant", source="NCIT:C6105"} ! ocular cancer +is_a: MONDO:0021225 {source="MONDO:Redundant", source="NCIT:C6105"} ! uvea neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001768 ! uvea +property_value: exactMatch DOID:3479 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334629 +property_value: exactMatch NCIT:C6105 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002661 +name: uveal disorder +def: "A non-neoplastic or neoplastic disorder that affects the uvea. Representative examples include uveitis, chorioretinitis, and uveal melanoma." [NCIT:P378] +synonym: "disease of uvea" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of uvea" EXACT [] +synonym: "disorder of uvea" EXACT [MONDO:patterns/location_top] +synonym: "disorder of uveal tract" RELATED [MONDO:patterns/location_top] +synonym: "uvea disease" EXACT [MONDO:patterns/location] +synonym: "uvea disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "uveal disease" EXACT [NCIT:C26908] +synonym: "uveal diseases" RELATED [GARD:0008192] +synonym: "uveal disorder" EXACT [NCIT:C26908] +synonym: "uveal tract disease" EXACT [MONDO:patterns/location] +xref: DOID:3480 {source="MONDO:equivalentTo"} +xref: GARD:0008192 {source="MONDO:equivalentTo", source="MONDO:shared-xref"} +xref: MESH:D014603 {source="MONDO:equivalentTo", source="DOID:3480"} +xref: NCIT:C26908 {source="MONDO:equivalentTo", source="DOID:3480"} +xref: SCTID:95678007 {source="MONDO:equivalentTo", source="DOID:3480"} +xref: UMLS:C0042161 {source="NCIT:C26908", source="MONDO:equivalentTo", source="DOID:3480"} +is_a: MONDO:0005328 {source="DOID:3480", source="MESH:D014603", source="MONDO:Redundant", source="NCIT:C26908"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001768 ! uvea +relationship: disease_has_location UBERON:0001768 ! uvea +property_value: exactMatch DOID:3480 +property_value: exactMatch http://identifiers.org/mesh/D014603 +property_value: exactMatch http://identifiers.org/snomedct/95678007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042161 +property_value: exactMatch NCIT:C26908 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002665 +name: extrahepatic bile duct adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of extrahepatic bile duct" EXACT [DOID:3495, NCIT:C7975] +synonym: "adenocarcinoma of the extrahepatic bile duct" EXACT [DOID:3495, NCIT:C7975] +synonym: "extrahepatic bile duct adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C7975] +xref: DOID:3495 {source="MONDO:equivalentTo"} +xref: NCIT:C7975 {source="DOID:3495", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0279659 {source="DOID:3495", source="MONDO:equivalentTo", source="NCIT:C7975"} +is_a: MONDO:0003090 {source="DOID:3495", source="MONDO:Redundant", source="NCIT:C7975"} ! extrahepatic bile duct carcinoma +is_a: MONDO:0003193 {source="DOID:3495", source="MONDO:Redundant", source="NCIT:C7975"} ! bile duct adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0003703 ! extrahepatic bile duct +property_value: exactMatch DOID:3495 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279659 +property_value: exactMatch NCIT:C7975 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002670 +name: ampulla of vater adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the hepatopancreatic ampulla" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of ampulla of Vater" EXACT [NCIT:C6650] +synonym: "adenocarcinoma of ampulla of vater" RELATED [DOID:3502] +synonym: "ampulla of Vater adenocarcinoma" EXACT [NCIT:C6650] +synonym: "ampullary adenocarcinoma" EXACT [DOID:3502, NCIT:C6650] +synonym: "hepatopancreatic ampulla adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "invasive adenocarcinoma of the ampullary region" EXACT [NCIT:C6650] +xref: DOID:3502 {source="MONDO:equivalentTo"} +xref: EFO:0008490 {source="MONDO:equivalentTo"} +xref: NCIT:C6650 {source="DOID:3502", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332243 {source="NCIT:C6650", source="DOID:3502", source="MONDO:equivalentTo"} +is_a: MONDO:0002665 ! extrahepatic bile duct adenocarcinoma +is_a: MONDO:0006186 {source="DOID:3502", source="MONDO:Entailed", source="MONDO:Redundant"} ! duodenal adenocarcinoma +is_a: MONDO:0017590 {source="DOID:3502", source="EFO:0008490", source="MONDO:Redundant", source="NCIT:C6650"} ! carcinoma of the ampulla of vater +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +property_value: exactMatch DOID:3502 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332243 +property_value: exactMatch NCIT:C6650 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002681 +name: choroid plexus cancer +def: "A malignant neoplasm involving the choroid plexus" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of choroid plexus" EXACT [MONDO:patterns/cancer] +synonym: "choroid plexus cancer" EXACT [MONDO:patterns/location] +synonym: "choroid plexus neoplasm" BROAD [DOID:3540] +synonym: "malignant choroid plexus neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4533] +synonym: "malignant choroid plexus neoplasms" EXACT [NCIT:C4533] +synonym: "malignant choroid plexus tumor" EXACT [NCIT:C4533] +synonym: "malignant choroid plexus tumors" EXACT [NCIT:C4533] +synonym: "malignant neoplasm of choroid plexus" EXACT [MONDO:patterns/cancer, NCIT:C4533] +synonym: "malignant neoplasm of the choroid plexus" EXACT [NCIT:C4533] +synonym: "malignant tumor of choroid plexus" EXACT [NCIT:C4533] +synonym: "malignant tumor of the choroid plexus" EXACT [NCIT:C4533] +synonym: "tumor of choroid plexus" BROAD [DOID:3540] +xref: DOID:3540 {source="MONDO:equivalentTo"} +xref: NCIT:C4533 {source="MONDO:equivalentTo"} +is_a: MONDO:0002095 ! vascular cancer +is_a: MONDO:0002682 ! cerebral ventricle cancer +is_a: MONDO:0016717 {source="NCIT:C4533"} ! choroid plexus neoplasm +is_a: MONDO:0020676 ! disorder of central nervous system or retinal vasculature +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001886 ! choroid plexus +relationship: disease_has_location UBERON:0001886 ! choroid plexus +property_value: exactMatch DOID:3540 +property_value: exactMatch NCIT:C4533 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/16 xsd:string + +[Term] +id: MONDO:0002682 +name: cerebral ventricle cancer +def: "A neoplasm that involves a brain ventricle. It may be a primary neoplasm arising from a brain ventricle, a metastasis from a distant anatomic site, or an extension of an invasive neoplasm from an adjacent brain structure." [NCIT:C2937] +subset: gard_rare {source="GARD:0006025"} +synonym: "brain neoplasms, intraventricular" EXACT [NCIT:C2937] +synonym: "brain ventricle cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of brain ventricle" EXACT [MONDO:patterns/cancer] +synonym: "cerebral ventricle neoplasm" EXACT [DOID:3541] +synonym: "intraventricular brain neoplasm" EXACT [NCIT:C2937] +synonym: "intraventricular brain neoplasms" EXACT [NCIT:C2937] +synonym: "intraventricular brain tumor" EXACT [NCIT:C2937] +synonym: "intraventricular neoplasm of brain" EXACT [NCIT:C2937] +synonym: "intraventricular neoplasm of the brain" EXACT [NCIT:C2937] +synonym: "intraventricular neoplasms" EXACT [NCIT:C2937] +synonym: "intraventricular tumor of brain" EXACT [DOID:3541, NCIT:C2937] +synonym: "intraventricular tumor of the brain" EXACT [NCIT:C2937] +synonym: "malignant brain ventricle neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of brain ventricle" EXACT [MONDO:patterns/cancer] +xref: DOID:3541 {source="MONDO:equivalentTo"} +xref: EFO:0007201 {source="MONDO:equivalentTo"} +xref: GARD:0006025 {source="MONDO:equivalentTo"} +xref: ICD9:191.5 {source="DOID:3541"} +xref: MESH:D002551 {source="DOID:3541", source="MONDO:equivalentTo"} +xref: NCIT:C2937 {source="DOID:3541", source="MONDO:equivalentTo"} +xref: SCTID:126958000 {source="DOID:3541", source="MONDO:equivalentTo"} +is_a: MONDO:0001657 ! brain cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0004086 ! brain ventricle +relationship: disease_has_location UBERON:0004086 ! brain ventricle +property_value: exactMatch DOID:3541 +property_value: exactMatch http://identifiers.org/mesh/D002551 +property_value: exactMatch http://identifiers.org/snomedct/126958000 +property_value: exactMatch NCIT:C2937 +property_value: excluded_subClassOf MONDO:0002731 {source="DOID:3541"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6025/cerebral-ventricle-cancer xsd:anyURI {source="GARD:0006025"} + +[Term] +id: MONDO:0002685 +name: childhood choroid plexus carcinoma +def: "A choroid plexus carcinoma that occurs during childhood." [NCIT:C124292] +synonym: "childhood choroid plexus cancer" RELATED [DOID:3545] +synonym: "childhood choroid plexus carcinoma" EXACT [NCIT:C124292] +synonym: "childhood choroid plexus neoplasm" BROAD [DOID:3545] +synonym: "choroid plexus carcinoma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric choroid plexus carcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: DOID:3545 {source="MONDO:equivalentTo"} +xref: NCIT:C124292 {source="MONDO:equivalentTo"} +xref: UMLS:C0280623 {source="NCIT:C124292", source="MONDO:equivalentTo", source="DOID:3545"} +is_a: MONDO:0002071 {source="DOID:3545/inferred", source="NCIT:C124292"} ! supratentorial cancer +is_a: MONDO:0006517 ! childhood malignant neoplasm +is_a: MONDO:0016718 ! choroid plexus carcinoma +is_a: MONDO:0024744 {source="MONDO:Redundant", source="NCIT:C124292"} ! childhood choroid plexus neoplasm +intersection_of: MONDO:0016718 ! choroid plexus carcinoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:3545 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280623 +property_value: exactMatch NCIT:C124292 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002687 +name: superior mesenteric artery syndrome +def: "Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due toloss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment." [https://rarediseases.info.nih.gov/diseases/7712/superior-mesenteric-artery-syndrome] +subset: gard_rare {source="GARD:0007712"} +synonym: "Arteriomesenteric duodenal compression syndrome" RELATED [GARD:0007712] +synonym: "Cast syndrome" RELATED [GARD:0007712] +synonym: "superior mesenteric artery syndrome" EXACT [DOID:3557] +synonym: "superior mesenteric artery syndromic disease" EXACT [MONDO:patterns/location] +synonym: "syndromic disease of superior mesenteric artery" EXACT [MONDO:design_pattern] +synonym: "vascular compression of the duodenum" RELATED [GARD:0007712] +synonym: "Wilkie syndrome" RELATED [GARD:0007712] +xref: DOID:3557 {source="MONDO:equivalentTo"} +xref: EFO:1001201 {source="MONDO:equivalentTo"} +xref: GARD:0007712 {source="MONDO:equivalentTo"} +xref: MESH:D013478 {source="DOID:3557", source="MONDO:equivalentTo"} +xref: NCIT:C85175 {source="DOID:3557", source="MONDO:equivalentTo"} +xref: SCTID:197006009 {source="DOID:3557", source="MONDO:equivalentTo"} +xref: UMLS:C0038828 {source="DOID:3557", source="MONDO:equivalentTo", source="NCIT:C85175"} +is_a: MONDO:0002254 {source="DOID:3557", source="MONDO:Redundant", source="NCIT:C85175"} ! syndromic disease +is_a: MONDO:0002688 {source="DOID:3557", source="EFO:1001201", source="MESH:D013478"} ! duodenal obstruction +is_a: MONDO:0005561 ! aortic disorder +intersection_of: MONDO:0002254 ! syndromic disease +intersection_of: disease_has_location UBERON:0001182 ! superior mesenteric artery +relationship: disease_has_location UBERON:0001182 ! superior mesenteric artery +property_value: exactMatch DOID:3557 +property_value: exactMatch http://identifiers.org/mesh/D013478 +property_value: exactMatch http://identifiers.org/snomedct/197006009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038828 +property_value: exactMatch NCIT:C85175 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7712/superior-mesenteric-artery-syndrome xsd:anyURI {source="GARD:0007712"} + +[Term] +id: MONDO:0002688 +name: duodenal obstruction +def: "Blockage of the normal flow of stomach contents through the duodenum." [NCIT:P378] +xref: DOID:3558 {source="MONDO:equivalentTo"} +xref: EFO:1000908 {source="MONDO:equivalentTo"} +xref: MESH:D004380 {source="MONDO:equivalentTo", source="DOID:3558"} +xref: NCIT:C79548 {source="MONDO:otherHierarchy", source="DOID:3558"} +xref: SCTID:95532008 {source="MONDO:equivalentTo", source="DOID:3558"} +xref: UMLS:C0013292 {source="MONDO:equivalentTo", source="DOID:3558"} +is_a: MONDO:0002866 {source="DOID:3558", source="MESH:D004380"} ! duodenal disorder +is_a: MONDO:0004565 {source="DOID:3558", source="MESH:D004380"} ! intestinal obstruction +property_value: exactMatch DOID:3558 +property_value: exactMatch http://identifiers.org/mesh/D004380 +property_value: exactMatch http://identifiers.org/snomedct/95532008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013292 +property_value: relatedMatch NCIT:C79548 + +[Term] +id: MONDO:0002691 +name: liver cancer +def: "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma." [NCIT:C34803] +synonym: "Ca liver - primary" EXACT [DOID:3571] +synonym: "ca liver - primary" EXACT [DOID:3571] +synonym: "cancer of liver" EXACT [MONDO:patterns/cancer] +synonym: "hepatic cancer" EXACT [DOID:3571] +synonym: "hepatic neoplasm" EXACT [DOID:3571] +synonym: "liver cancer" EXACT [MONDO:patterns/location] +synonym: "malignant hepato-biliary neoplasm" EXACT [DOID:3571] +synonym: "malignant liver neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of liver" EXACT [DOID:3571, MONDO:patterns/cancer] +synonym: "malignant neoplasm of liver, not specified as primary or secondary" EXACT [DOID:3571, ICD9CM:155.2] +synonym: "malignant neoplasm of liver, primary" EXACT [DOID:3571, ICD9CM:155.0] +synonym: "malignant tumor of liver" EXACT [DOID:3571] +synonym: "non-resectable primary hepatic malignant neoplasm" EXACT [DOID:3571] +synonym: "primary cancer of liver" RELATED [GARD:0006608] +synonym: "primary liver cancer" EXACT [DOID:3571] +synonym: "primary malignant liver neoplasm" EXACT [NCIT:C34803] +synonym: "primary malignant neoplasm of liver" EXACT [DOID:3571, NCIT:C34803] +synonym: "primary tumor of the liver" RELATED [GARD:0006608] +synonym: "Resectable malignant neoplasm of liver" EXACT [DOID:3571, NCIT:C7692] +synonym: "resectable malignant neoplasm of the liver" EXACT [DOID:3571] +xref: DOID:3571 {source="MONDO:equivalentTo"} +xref: GARD:0006608 {source="MONDO:equivalentTo", source="MONDO:shared-xref"} +xref: ICD9:155.0 {source="DOID:3571"} +xref: ICD9:155.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:3571"} +xref: NCIT:C34803 {source="MONDO:equivalentTo", source="DOID:3571"} +xref: SCTID:93870000 {source="MONDO:equivalentTo", source="DOID:3571"} +xref: UMLS:C0024620 {source="NCIT:C34803", source="MONDO:equivalentTo", source="DOID:3571"} +xref: UMLS:C0345904 {source="MONDO:equivalentTo", source="DOID:3571"} +xref: UMLS:C0854795 {source="MONDO:equivalentTo", source="DOID:3571"} +is_a: MONDO:0002516 {source="DOID:3571", source="MONDO:Redundant", source="NCIT:C34803/inferred"} ! digestive system cancer +is_a: MONDO:0004721 ! liver neoplasm +is_a: MONDO:0021069 ! malignant endocrine neoplasm +is_a: MONDO:0024477 {source="NCIT:C34803"} ! liver and intrahepatic bile duct neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002107 ! liver +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +property_value: exactMatch DOID:3571 +property_value: exactMatch http://identifiers.org/snomedct/93870000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024620 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345904 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854795 +property_value: exactMatch NCIT:C34803 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002708 +name: retinitis +def: "Inflammation of the retina." [NCIT:P378] +synonym: "inflammation of retina" EXACT [] +synonym: "retina inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:3612 {source="MONDO:equivalentTo"} +xref: MESH:D012173 {source="DOID:3612", source="MONDO:equivalentTo"} +xref: NCIT:C115993 {source="DOID:3612", source="MONDO:equivalentTo"} +xref: SCTID:399463004 {source="DOID:3612", source="MONDO:equivalentTo"} +xref: UMLS:C0035333 {source="DOID:3612", source="MONDO:equivalentTo", source="NCIT:C115993"} +is_a: MONDO:0005283 {source="DOID:3612", source="MESH:D012173", source="MONDO:Redundant"} ! retinal disorder +is_a: MONDO:0006918 ! posterior uveitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000966 ! retina +relationship: disease_has_inflammation_site UBERON:0000966 ! retina +property_value: exactMatch DOID:3612 +property_value: exactMatch http://identifiers.org/mesh/D012173 +property_value: exactMatch http://identifiers.org/snomedct/399463004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035333 +property_value: exactMatch NCIT:C115993 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0002713 +name: epidural spinal canal neoplasm +def: "A primary or metastatic neoplasm that involves the space between the vertebral periosteum and dura mater that surrounds the spinal cord." [NCIT:C3019] +synonym: "epidural neoplasm" EXACT [NCIT:C3019] +synonym: "epidural space neoplasm" EXACT [] +synonym: "epidural space tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "epidural spinal canal neoplasm" EXACT [NCIT:C3019] +synonym: "epidural spinal canal tumor" EXACT [NCIT:C3019] +synonym: "epidural spinal canal tumors" EXACT [NCIT:C3019] +synonym: "epidural spinal neoplasms" EXACT [NCIT:C3019] +synonym: "epidural spinal tumors" EXACT [NCIT:C3019] +synonym: "epidural tumor" EXACT [NCIT:C3019] +synonym: "extradural neoplasm" EXACT [NCIT:C3019] +synonym: "extradural spinal canal neoplasm" EXACT [NCIT:C3019] +synonym: "extradural spinal canal neoplasms" EXACT [NCIT:C3019] +synonym: "extradural spinal canal tumor" EXACT [NCIT:C3019] +synonym: "extradural spinal neoplasms" EXACT [NCIT:C3019] +synonym: "extradural spinal tumors" EXACT [NCIT:C3019] +synonym: "extradural tumor" EXACT [DOID:3618, NCIT:C3019] +synonym: "neoplasm of epidural space" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of epidural spinal canal" EXACT [NCIT:C3019] +synonym: "neoplasm of extradural spinal canal" EXACT [NCIT:C3019] +synonym: "neoplasm of the epidural spinal canal" EXACT [NCIT:C3019] +synonym: "neoplasm of the extradural spinal canal" EXACT [NCIT:C3019] +synonym: "tumor of epidural space" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of epidural spinal canal" EXACT [NCIT:C3019] +synonym: "tumor of extradural spinal canal" EXACT [NCIT:C3019] +synonym: "tumor of the epidural spinal canal" EXACT [NCIT:C3019] +synonym: "tumor of the extradural spinal canal" EXACT [NCIT:C3019] +xref: DOID:3618 {source="MONDO:equivalentTo"} +xref: EFO:1000923 {source="MONDO:equivalentTo"} +xref: MESH:D015174 {source="MONDO:equivalentTo", source="DOID:3618"} +xref: NCIT:C3019 {source="MONDO:equivalentTo", source="DOID:3618"} +xref: UMLS:C0014536 {source="MONDO:equivalentTo", source="DOID:3618", source="NCIT:C3019"} +is_a: MONDO:0000812 ! vertebral column disorder +is_a: MONDO:0005070 {source="DOID:3618/inferred", source="EFO:1000923/inferred", source="MESH:D015174/inferred", source="MONDO:Redundant", source="NCIT:C3019/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003691 ! epidural space +relationship: disease_has_location UBERON:0003691 ! epidural space +property_value: exactMatch DOID:3618 +property_value: exactMatch http://identifiers.org/mesh/D015174 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014536 +property_value: exactMatch NCIT:C3019 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002714 +name: central nervous system cancer +def: "A malignant neoplasm involving the central nervous system" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of central nervous system" EXACT [MONDO:patterns/cancer, NCIT:C4627] +synonym: "cancer of CNS" EXACT [NCIT:C4627] +synonym: "cancer of the central nervous system" EXACT [NCIT:C4627] +synonym: "cancer of the CNS" EXACT [NCIT:C4627] +synonym: "central nervous system cancer" EXACT [MONDO:patterns/location, NCIT:C4627] +synonym: "central nervous system neoplasms, malignant" EXACT [NCIT:C4627] +synonym: "central nervous system tumor" BROAD [DOID:3620] +synonym: "central nervous system tumors" EXACT [DOID:3620, NCIT:C9293] +synonym: "CNS cancer" EXACT [NCIT:C4627] +synonym: "CNS malignant neoplasms" EXACT [NCIT:C4627] +synonym: "CNS neoplasm" BROAD [DOID:3620] +synonym: "CNS neoplasms, malignant" EXACT [NCIT:C4627] +synonym: "malignant central nervous system neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4627] +synonym: "malignant central nervous system tumor" EXACT [NCIT:C4627] +synonym: "malignant CNS neoplasm" EXACT [NCIT:C4627] +synonym: "malignant CNS neoplasms" EXACT [NCIT:C4627] +synonym: "malignant CNS tumor" EXACT [NCIT:C4627] +synonym: "malignant neoplasm of central nervous system" EXACT [MONDO:patterns/cancer, NCIT:C4627] +synonym: "malignant neoplasm of CNS" EXACT [NCIT:C4627] +synonym: "malignant neoplasm of the central nervous system" EXACT [NCIT:C4627] +synonym: "malignant neoplasm of the CNS" EXACT [NCIT:C4627] +synonym: "malignant tumor of central nervous system" EXACT [NCIT:C4627] +synonym: "malignant tumor of CNS" EXACT [DOID:3620, NCIT:C4627] +synonym: "malignant tumor of the central nervous system" EXACT [NCIT:C4627] +synonym: "malignant tumor of the CNS" EXACT [NCIT:C4627] +xref: DOID:3620 {source="MONDO:equivalentTo"} +xref: EFO:0000326 {source="DOID:3620", source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D016543 {source="DOID:3620", source="MONDO:equivalentTo"} +xref: NCIT:C4627 {source="DOID:3620", source="MONDO:equivalentTo"} +xref: SCTID:126951006 {source="DOID:3620", source="MONDO:equivalentTo"} +is_a: MONDO:0005872 {source="DOID:3620", source="MESH:D016543", source="MONDO:Redundant", source="NCIT:C4627"} ! nervous system cancer +is_a: MONDO:0006130 ! central nervous system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:3620 +property_value: exactMatch http://identifiers.org/mesh/D016543 +property_value: exactMatch http://identifiers.org/snomedct/126951006 +property_value: exactMatch NCIT:C4627 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002715 +name: uterine cancer +def: "Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix." [NCIT:C3552] +synonym: "CA - cancer of uterus" EXACT [DOID:363] +synonym: "cancer of the uterus" EXACT [NCIT:C3552] +synonym: "cancer of uterus" EXACT [MONDO:patterns/cancer, NCIT:C3552] +synonym: "malignant neoplasm of the uterus" EXACT [NCIT:C3552] +synonym: "malignant neoplasm of uterus" EXACT [DOID:363, MONDO:patterns/cancer, NCIT:C3552] +synonym: "malignant tumor of the uterus" EXACT [NCIT:C3552] +synonym: "malignant tumor of uterus" EXACT [NCIT:C3552] +synonym: "malignant uterine neoplasm" EXACT [NCIT:C3552] +synonym: "malignant uterine tumor" EXACT [DOID:363, NCIT:C3552] +synonym: "malignant uterus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of uterus" BROAD [DOID:363] +synonym: "tumour of uterus" BROAD [DOID:363] +synonym: "uterine cancer" EXACT [NCIT:C3552] +synonym: "uterine tumor" BROAD [DOID:363, NCIT:C3435] +synonym: "uterus cancer" EXACT [MONDO:patterns/location] +synonym: "uterus neoplasm" BROAD [DOID:363] +xref: DOID:363 {source="MONDO:equivalentTo"} +xref: ICD9:179 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:363"} +xref: MESH:D014594 {source="MONDO:equivalentTo", source="DOID:363"} +xref: NCIT:C3552 {source="MONDO:equivalentTo", source="DOID:363"} +xref: SCTID:371973000 {source="MONDO:equivalentTo", source="DOID:363"} +is_a: MONDO:0001416 {source="DOID:363", source="NCIT:C3552"} ! female reproductive organ cancer +is_a: MONDO:0021353 {source="MONDO:Redundant", source="NCIT:C3552"} ! tumor of uterus +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000995 ! uterus +property_value: exactMatch DOID:363 +property_value: exactMatch http://identifiers.org/mesh/D014594 +property_value: exactMatch http://identifiers.org/snomedct/371973000 +property_value: exactMatch NCIT:C3552 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002716 +name: childhood spinal cord tumor +def: "A benign or malignant neoplasm affecting the spinal cord during childhood." [NCIT:P378] +synonym: "childhood spinal cord neoplasm" EXACT [DOID:3637, NCIT:C9234] +synonym: "pediatric spinal cord neoplasm" EXACT [MONDO:patterns/childhood] +synonym: "spinal cord neoplasm of childhood" EXACT [MONDO:patterns/childhood] +xref: DOID:3637 {source="MONDO:equivalentTo"} +xref: NCIT:C9234 {source="MONDO:equivalentTo", source="DOID:3637"} +xref: UMLS:C1134515 {source="NCIT:C9234", source="MONDO:equivalentTo", source="DOID:3637"} +is_a: MONDO:0021079 ! childhood neoplasm +is_a: MONDO:0021234 ! spinal cord neoplasm +intersection_of: MONDO:0021234 ! spinal cord neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:3637 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1134515 +property_value: exactMatch NCIT:C9234 +property_value: excluded_subClassOf MONDO:0003544 {source="DOID:3637"} + +[Term] +id: MONDO:0002720 +name: sella turcica neoplasm +def: "A benign or malignant neoplasm that occurs in sella turcica. Representative examples include craniopharyngioma and pituitary gland adenoma." [NCIT:C4944] +synonym: "neoplasm of sella turcica" EXACT [NCIT:C4944] +synonym: "neoplasm of the sella turcica" EXACT [NCIT:C4944] +synonym: "sella turcica neoplasm" EXACT [NCIT:C4944] +synonym: "sella turcica tumor" EXACT [NCIT:C4944] +synonym: "sellar neoplasm" EXACT [NCIT:C4944] +synonym: "sellar tumor" EXACT [NCIT:C4944] +synonym: "selt" RELATED [ONCOTREE:SELT] +synonym: "tumor of sella turcica" EXACT [DOID:3643, NCIT:C4944] +synonym: "tumor of the sella turcica" EXACT [NCIT:C4944] +xref: DOID:3643 {source="MONDO:equivalentTo"} +xref: NCIT:C4944 {source="DOID:3643", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:SELT {source="MONDO:equivalentTo"} +xref: UMLS:C0748616 {source="DOID:3643", source="MONDO:equivalentTo", source="NCIT:C4944"} +is_a: MONDO:0002785 {source="DOID:3643", source="NCIT:C4944"} ! skull base neoplasm +property_value: exactMatch DOID:3643 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0748616 +property_value: exactMatch NCIT:C4944 + +[Term] +id: MONDO:0002722 +name: olfactory nerve neoplasm +def: "Benign and malignant neoplasms which arise from or metastasize to the olfactory or first cranial nerve. Clinical features may include facial pain and impairments of taste or smell." [NCIT:C5121] +synonym: "cranial nerve I neoplasms" EXACT [NCIT:C5121] +synonym: "first cranial nerve neoplasm" EXACT [NCIT:C5121] +synonym: "first cranial nerve neoplasms" EXACT [NCIT:C5121] +synonym: "first cranial nerve tumor" EXACT [NCIT:C5121] +synonym: "neoplasm of first cranial nerve" EXACT [NCIT:C5121] +synonym: "neoplasm of olfactory nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5121] +synonym: "neoplasm of the first cranial nerve" EXACT [NCIT:C5121] +synonym: "neoplasm of the olfactory nerve" EXACT [NCIT:C5121] +synonym: "neoplasms, cranial nerve I" EXACT [NCIT:C5121] +synonym: "neoplasms, olfactory nerve" EXACT [NCIT:C5121] +synonym: "olfactory nerve neoplasm" EXACT [NCIT:C5121] +synonym: "olfactory nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "olfactory nerve neoplasms" EXACT [NCIT:C5121] +synonym: "olfactory nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5121] +synonym: "olfactory neural neoplasm" EXACT [NCIT:C5121] +synonym: "olfactory neural tumor" EXACT [DOID:8256, NCIT:C5121] +synonym: "tumor of first cranial nerve" EXACT [NCIT:C5121] +synonym: "tumor of olfactory nerve" EXACT [DOID:366, MONDO:patterns/neoplasm, NCIT:C5121] +synonym: "tumor of the first cranial nerve" EXACT [NCIT:C5121] +synonym: "tumor of the olfactory nerve" EXACT [NCIT:C5121] +xref: DOID:366 {source="MONDO:equivalentObsolete"} +xref: DOID:8256 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5121 {source="MONDO:equivalentTo", source="DOID:366"} +xref: SCTID:126967000 {source="MONDO:equivalentTo", source="DOID:366"} +xref: UMLS:C0346319 {source="NCIT:C5121", source="MONDO:equivalentTo", source="DOID:366"} +is_a: MONDO:0002633 {source="DOID:366/inferred", source="DOID:8256/inferred", source="MONDO:Redundant", source="NCIT:C5121"} ! cranial nerve neoplasm +is_a: MONDO:0002727 {source="MONDO:Redundant", source="NCIT:C5121"} ! olfactory nerve disorder +is_a: MONDO:0021211 ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001579 ! olfactory nerve +property_value: exactMatch DOID:8256 +property_value: exactMatch http://identifiers.org/snomedct/126967000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346319 +property_value: exactMatch NCIT:C5121 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002724 +name: mast cell neoplasm +def: "A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems. Recent data suggest that most variants of mast cell neoplasms are clonal disorders. (WHO, 2001)" [NCIT:C9295] +synonym: "mast cell neoplasm" EXACT [NCIT:C9295] +synonym: "Mast cell proliferative disease" EXACT [DOID:3664, NCIT:C9295] +synonym: "Mast cell tumor" EXACT [NCIT:C9295] +synonym: "mast cell tumor" EXACT [DOID:3664, NCIT:C9295] +synonym: "neoplasm of Mast cells" EXACT [NCIT:C9295] +synonym: "neoplasm of the Mast cells" EXACT [NCIT:C9295] +synonym: "tumor of Mast cells" EXACT [NCIT:C9295] +synonym: "tumor of the Mast cells" EXACT [NCIT:C9295] +xref: DOID:3664 {source="MONDO:equivalentTo"} +xref: EFO:0009000 {source="MONDO:equivalentTo"} +xref: ICD9:238.79 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C9295 {source="DOID:3664", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:414653009 {source="DOID:3664", source="MONDO:equivalentTo"} +xref: UMLS:C0334664 {source="DOID:3664", source="MONDO:equivalentTo", source="NCIT:C9295"} +is_a: MONDO:0005170 {source="EFO:0009000", source="NCIT:C9295"} ! myeloid neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_basis_in_dysfunction_of CL:0000097 ! mast cell +relationship: disease_has_basis_in_dysfunction_of CL:0000097 ! mast cell +property_value: exactMatch DOID:3664 +property_value: exactMatch http://identifiers.org/snomedct/414653009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334664 +property_value: exactMatch NCIT:C9295 + +[Term] +id: MONDO:0002727 +name: olfactory nerve disorder +def: "A disease involving the olfactory nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of olfactory nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of olfactory nerve" EXACT [] +synonym: "disorder of 1st nerve" EXACT [DOID:367, NCIT:C27210] +synonym: "disorder of olfactory [1st] nerve" EXACT [DOID:367, ICD9CM:352.0] +synonym: "disorder of olfactory nerve" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the 1st nerve" EXACT [NCIT:C27210] +synonym: "olfactory nerve disease" EXACT [MONDO:patterns/location] +synonym: "olfactory nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "olfactory nerve disorder" EXACT [NCIT:C27210] +xref: DOID:367 {source="MONDO:equivalentTo"} +xref: ICD9:352.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:367"} +xref: MESH:D020431 {source="MONDO:equivalentTo", source="DOID:367"} +xref: NCIT:C27210 {source="MONDO:equivalentTo", source="DOID:367"} +xref: SCTID:68982002 {source="MONDO:equivalentTo", source="DOID:367"} +xref: UMLS:C0751937 {source="NCIT:C27210", source="MONDO:equivalentTo", source="DOID:367"} +is_a: MONDO:0003569 {source="DOID:367/inferred", source="MESH:D020431", source="MONDO:Redundant", source="NCIT:C27210"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +is_a: MONDO:0005560 {source="DOID:367"} ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001579 ! olfactory nerve +relationship: disease_has_location UBERON:0001579 ! olfactory nerve +property_value: exactMatch DOID:367 +property_value: exactMatch http://identifiers.org/mesh/D020431 +property_value: exactMatch http://identifiers.org/snomedct/68982002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751937 +property_value: exactMatch NCIT:C27210 +property_value: excluded_subClassOf MONDO:0002639 {source="DOID:367"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002730 +name: childhood kidney neoplasm +def: "A kidney neoplasm that occurs during childhood." [MONDO:design_pattern] +synonym: "childhood kidney neoplasm" EXACT [NCIT:C6563] +synonym: "childhood kidney tumor" EXACT [NCIT:C6563] +synonym: "childhood renal neoplasm" EXACT [NCIT:C6563] +synonym: "childhood renal tumor" EXACT [NCIT:C6563] +synonym: "kidney neoplasm" BROAD [NCIT:C6563] +synonym: "kidney neoplasm of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric kidney neoplasm" EXACT [MONDO:patterns/childhood, NCIT:C6563] +synonym: "pediatric kidney tumor" EXACT [NCIT:C6563] +synonym: "pediatric renal neoplasm" EXACT [NCIT:C6563] +synonym: "pediatric renal tumor" EXACT [DOID:3675, NCIT:C6563] +xref: DOID:3675 {source="MONDO:equivalentTo"} +xref: NCIT:C6563 {source="DOID:3675", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1333003 {source="DOID:3675", source="NCIT:C6563", source="MONDO:equivalentTo"} +is_a: MONDO:0021079 {source="MONDO:Redundant", source="NCIT:C6563"} ! childhood neoplasm +is_a: MONDO:0021163 {source="MONDO:Redundant", source="NCIT:C6563"} ! kidney neoplasm +intersection_of: MONDO:0021163 ! kidney neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:3675 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333003 +property_value: exactMatch NCIT:C6563 +property_value: excluded_subClassOf MONDO:0002367 {source="DOID:3675"} + +[Term] +id: MONDO:0002731 +name: cerebral hemisphere cancer +def: "A cancer that involves the cerebral hemisphere." [MONDO:patterns/location] +synonym: "cancer of cerebral hemisphere" EXACT [MONDO:patterns/cancer] +synonym: "cancer of telencephalon" EXACT [MONDO:patterns/cancer] +synonym: "cerebral cancer" EXACT [DOID:368, NCIT:C4577] +synonym: "cerebrum cancer" RELATED [DOID:368] +synonym: "malignant cerebral hemisphere neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant cerebral hemispheric neoplasm" EXACT [NCIT:C4577] +synonym: "malignant cerebral hemispheric tumor" EXACT [NCIT:C4577] +synonym: "malignant cerebral neoplasm" EXACT [NCIT:C4577] +synonym: "malignant cerebral tumor" EXACT [NCIT:C4577] +synonym: "malignant neoplasm of cerebral hemisphere" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of cerebral hemispheres" EXACT [NCIT:C4577] +synonym: "malignant neoplasm of cerebrum" EXACT [NCIT:C4577] +synonym: "malignant neoplasm of telencephalon" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the cerebral hemispheres" EXACT [NCIT:C4577] +synonym: "malignant neoplasm of the cerebrum" EXACT [NCIT:C4577] +synonym: "malignant telencephalon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of cerebral hemispheres" EXACT [NCIT:C4577] +synonym: "malignant tumor of cerebrum" EXACT [NCIT:C4577] +synonym: "malignant tumor of the cerebral hemispheres" EXACT [NCIT:C4577] +synonym: "malignant tumor of the cerebrum" EXACT [NCIT:C4577] +synonym: "telencephalon cancer" EXACT [MONDO:patterns/location] +synonym: "tumor of cerebrum" BROAD [DOID:368, NCIT:C4874] +xref: DOID:368 {source="MONDO:equivalentTo"} +xref: ICD9:191.8 {source="DOID:368"} +xref: NCIT:C4577 {source="MONDO:equivalentTo"} +xref: SCTID:429033009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002071 {source="DOID:368", source="NCIT:C4577"} ! supratentorial cancer +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C4577"} ! neoplasm of cerebral hemisphere +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001869 ! cerebral hemisphere +property_value: exactMatch DOID:368 +property_value: exactMatch http://identifiers.org/snomedct/429033009 +property_value: exactMatch NCIT:C4577 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002732 +name: lung benign neoplasm +def: "A non-metastasizing neoplasm that arises from the lung parenchyma or the bronchi. Representative examples include lung adenoma, lung hamartoma, and endobronchial lipoma." [NCIT:C4454] +synonym: "benign lung neoplasm" EXACT [NCIT:C4454] +synonym: "benign lung tumor" EXACT [NCIT:C4454] +synonym: "benign neoplasm of lung" EXACT [NCIT:C4454] +synonym: "benign neoplasm of the lung" EXACT [NCIT:C4454] +synonym: "benign tumor of lung" EXACT [NCIT:C4454] +synonym: "benign tumor of the lung" EXACT [NCIT:C4454] +synonym: "lung benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "tumor of the lung" BROAD [DOID:3683, NCIT:C3200] +xref: DOID:3683 {source="MONDO:equivalentTo"} +xref: NCIT:C4454 {source="MONDO:equivalentTo"} +is_a: MONDO:0000382 {source="DOID:3683", source="MONDO:Entailed", source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C4454"} ! thoracic benign neoplasm +is_a: MONDO:0021117 {source="MONDO:Redundant", source="NCIT:C4454"} ! lung neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:3683 +property_value: exactMatch NCIT:C4454 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0002735 +name: anal canal adenocarcinoma +def: "An anal adenocarcinoma arising from the anal canal mucosa. Morphologically, it resembles the adenocarcinoma which arises from the colorectal glandular epithelium. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding." [NCIT:C7471] +subset: ordo_disease {source="Orphanet:424016"} +synonym: "adenocarcinoma arising in anal mucosa" EXACT [NCIT:C7471] +synonym: "adenocarcinoma arising in the anal mucosa" EXACT [NCIT:C7471] +synonym: "adenocarcinoma of anal canal" EXACT [DOID:3692, NCIT:C7471] +synonym: "adenocarcinoma of the anal canal" EXACT [DOID:3692, MONDO:0018518, NCIT:C7471] +synonym: "anal canal adenocarcinoma" EXACT [MONDO:ambiguous, MONDO:patterns/location, NCIT:C7471] +synonym: "anal canal adenocarcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:3692 {source="MONDO:equivalentTo"} +xref: HP:0030439 {source="MONDO:otherHierarchy"} +xref: ICD10CM:C21.1 {source="Orphanet:424016", source="Orphanet:424016/ntbt"} +xref: NCIT:C7471 {source="MONDO:equivalentTo", source="DOID:3692"} +xref: Orphanet:424016 {source="MONDO:equivalentTo"} +xref: SCTID:764845008 {source="MONDO:equivalentTo"} +xref: UMLS:C1332259 {source="MONDO:equivalentTo", source="DOID:3692", source="NCIT:C7471"} +is_a: MONDO:0002652 ! anus adenocarcinoma +is_a: MONDO:0007108 {source="DOID:3692", source="MONDO:Redundant", source="NCIT:C7471", source="Orphanet:424016"} ! anal canal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000159 ! anal canal +property_value: exactMatch DOID:3692 +property_value: exactMatch http://identifiers.org/snomedct/764845008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332259 +property_value: exactMatch NCIT:C7471 +property_value: exactMatch Orphanet:424016 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: IAO:0000589 "anal canal adenocarcinoma (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/C21.1 + +[Term] +id: MONDO:0002741 +name: uterine ligament adenocarcinoma +def: "A rare adenocarcinoma that arises from the uterine ligament." [NCIT:C40135] +synonym: "uterine ligament adenocarcinoma" EXACT [NCIT:C40135] +xref: DOID:3700 {source="MONDO:equivalentTo"} +xref: NCIT:C40135 {source="DOID:3700", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1519866 {source="DOID:3700", source="MONDO:equivalentTo", source="NCIT:C40135"} +is_a: MONDO:0003612 {source="DOID:3700", source="MONDO:Redundant", source="NCIT:C40135"} ! uterine ligament cancer +is_a: MONDO:0005153 ! cervical adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0036262 ! uterine ligament +property_value: exactMatch DOID:3700 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519866 +property_value: exactMatch NCIT:C40135 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002746 +name: fallopian tube adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the fallopian tube" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of fallopian tube" EXACT [NCIT:C6265] +synonym: "adenocarcinoma of the fallopian tube" EXACT [DOID:3706, NCIT:C6265] +synonym: "fallopian tube adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6265] +xref: DOID:3706 {source="MONDO:equivalentTo"} +xref: NCIT:C6265 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3706"} +xref: UMLS:C1333590 {source="NCIT:C6265", source="MONDO:equivalentTo", source="DOID:3706"} +is_a: MONDO:0004970 {source="DOID:3706", source="MONDO:Redundant", source="NCIT:C6265"} ! adenocarcinoma +is_a: MONDO:0006206 {source="DOID:3706", source="MONDO:Redundant", source="NCIT:C6265"} ! fallopian tube carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:3706 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333590 +property_value: exactMatch NCIT:C6265 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002751 +name: bladder adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the urinary bladder" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of bladder" EXACT [NCIT:C4032] +synonym: "adenocarcinoma of the bladder" EXACT [NCIT:C4032] +synonym: "adenocarcinoma of the urinary bladder" EXACT [DOID:3711, NCIT:C4032] +synonym: "adenocarcinoma of urinary bladder" EXACT [NCIT:C4032] +synonym: "blad" RELATED [ONCOTREE:BLAD] +synonym: "bladder adenocarcinoma" EXACT [MONDO:0006110, NCIT:C4032] +synonym: "urinary bladder adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C4032] +xref: DOID:3711 {source="MONDO:equivalentTo"} +xref: EFO:1000125 {source="MONDO:equivalentTo"} +xref: NCIT:C4032 {source="DOID:3711", source="MONDO:equivalentTo", source="EFO:1000125", source="MONDO:exact-label-match"} +xref: ONCOTREE:BLAD {source="MONDO:equivalentTo"} +xref: SCTID:255110003 {source="DOID:3711", source="MONDO:equivalentTo"} +xref: UMLS:C0279682 {source="NCIT:C4032", source="DOID:3711", source="MONDO:equivalentTo"} +is_a: MONDO:0004970 {source="DOID:3711", source="EFO:1000125", source="MONDO:Redundant", source="NCIT:C4032"} ! adenocarcinoma +is_a: MONDO:0004986 {source="DOID:3711", source="EFO:1000125", source="MONDO:Redundant", source="NCIT:C4032"} ! urinary bladder carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:3711 +property_value: exactMatch http://identifiers.org/snomedct/255110003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279682 +property_value: exactMatch NCIT:C4032 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002752 +name: ovarian adenocarcinoma +def: "An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma." [NCIT:C7700] +subset: ordo_disease {source="Orphanet:213504"} +synonym: "adenocarcinoma of ovary" EXACT [MONDO:0016246, NCIT:C7700] +synonym: "adenocarcinoma of the ovary" EXACT [DOID:3713, NCIT:C7700] +synonym: "ovarian adenocarcinoma" EXACT [DOID:3713, MONDO:0005600, NCIT:C7700, Orphanet:213504] +synonym: "ovary adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3713 {source="MONDO:equivalentTo"} +xref: EFO:0006460 {source="MONDO:equivalentTo"} +xref: ICD10CM:C56 {source="Orphanet:213504", source="Orphanet:213504/ntbt"} +xref: MedDRA:10051938 {source="Orphanet:213504", source="Orphanet:213504/e"} +xref: NCIT:C7700 {source="MONDO:equivalentTo", source="DOID:3713", source="EFO:0006460"} +xref: Orphanet:213504 {source="MONDO:equivalentTo"} +is_a: MONDO:0004970 {source="DOID:3713", source="EFO:0006460", source="MONDO:Redundant", source="NCIT:C7700"} ! adenocarcinoma +is_a: MONDO:0005140 {source="DOID:3713", source="EFO:0006460", source="MONDO:Entailed", source="NCIT:C7700"} ! ovarian carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: closeMatch http://identifiers.org/meddra/10051938 +property_value: exactMatch DOID:3713 +property_value: exactMatch NCIT:C7700 +property_value: exactMatch Orphanet:213504 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C56 + +[Term] +id: MONDO:0002760 +name: bladder squamous cell carcinoma +def: "A squamous cell carcinoma of the bladder arising from metaplastic epithelium. It represents less than 10% of bladder carcinomas. The exception is the Middle East along the Nile Valley, where it represents the most common form of carcinoma because of the endemic nature of schistosomiasis. Bladder squamous cell carcinoma is often associated with long-standing chronic inflammation of the bladder and usually has a poor prognosis. The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming." [NCIT:C4031] +synonym: "bladder epidermoid carcinoma" EXACT [NCIT:C4031] +synonym: "bladder squamous cell cancer" EXACT [NCIT:C4031] +synonym: "bladder squamous cell carcinoma" EXACT [MONDO:0006114, NCIT:C4031] +synonym: "BLSC" RELATED ABBREVIATION [ONCOTREE:BLSC] +synonym: "epidermoid carcinoma of bladder" EXACT [NCIT:C4031] +synonym: "epidermoid carcinoma of the bladder" EXACT [NCIT:C4031] +synonym: "epidermoid carcinoma of the urinary bladder" EXACT [DOID:3742, NCIT:C4031] +synonym: "epidermoid carcinoma of urinary bladder" EXACT [NCIT:C4031] +synonym: "squamous cell carcinoma of bladder" EXACT [NCIT:C4031] +synonym: "squamous cell carcinoma of the bladder" EXACT [NCIT:C4031] +synonym: "squamous cell carcinoma of the urinary bladder" EXACT [NCIT:C4031] +synonym: "squamous cell carcinoma of urinary bladder" EXACT [NCIT:C4031] +synonym: "urinary bladder epidermoid carcinoma" EXACT [NCIT:C4031] +synonym: "urinary bladder squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4031] +xref: DOID:3742 {source="MONDO:equivalentTo"} +xref: EFO:1000130 {source="MONDO:equivalentTo"} +xref: NCIT:C4031 {source="EFO:1000130", source="DOID:3742", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:BLSC {source="MONDO:equivalentTo"} +xref: SCTID:255111004 {source="DOID:3742", source="MONDO:equivalentTo"} +xref: UMLS:C0279681 {source="NCIT:C4031", source="DOID:3742", source="MONDO:equivalentTo"} +is_a: MONDO:0004986 {source="DOID:3742", source="EFO:1000130", source="MONDO:Redundant", source="NCIT:C4031"} ! urinary bladder carcinoma +is_a: MONDO:0005096 {source="DOID:3742", source="EFO:1000130", source="MONDO:Redundant", source="NCIT:C4031"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:3742 +property_value: exactMatch http://identifiers.org/snomedct/255111004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279681 +property_value: exactMatch NCIT:C4031 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002764 +name: urethra squamous cell carcinoma +def: "A well differentiated, moderately differentiated, or poorly differentiated squamous cell carcinoma that arises from the male or female urethra." [NCIT:P378] +synonym: "epidermoid carcinoma of the urethra" EXACT [NCIT:C6165] +synonym: "epidermoid carcinoma of urethra" EXACT [NCIT:C6165] +synonym: "squamous cell carcinoma of the urethra" EXACT [NCIT:C6165] +synonym: "squamous cell carcinoma of urethra" EXACT [NCIT:C6165] +synonym: "urethra epidermoid carcinoma" EXACT [NCIT:C6165] +synonym: "urethra squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6165] +synonym: "urethral epidermoid carcinoma" EXACT [DOID:3750, NCIT:C6165] +synonym: "urethral squamous cell cancer" EXACT [NCIT:C6165] +synonym: "urethral squamous cell carcinoma" EXACT [NCIT:C6165] +synonym: "USCC" RELATED ABBREVIATION [ONCOTREE:USCC] +xref: DOID:3750 {source="MONDO:equivalentTo"} +xref: NCIT:C6165 {source="DOID:3750", source="MONDO:equivalentTo"} +xref: ONCOTREE:USCC {source="MONDO:equivalentTo"} +xref: UMLS:C1336890 {source="DOID:3750", source="NCIT:C6165", source="MONDO:equivalentTo"} +is_a: MONDO:0005096 {source="DOID:3750", source="MONDO:Redundant", source="NCIT:C6165"} ! squamous cell carcinoma +is_a: MONDO:0021327 {source="MONDO:Redundant", source="NCIT:C6165"} ! carcinoma of urethra +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:3750 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336890 +property_value: exactMatch NCIT:C6165 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0002772 +name: intraventricular meningioma +def: "A meningioma that affects the ventricles of the brain." [NCIT:P378] +synonym: "brain ventricle meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of brain ventricle" EXACT [] +xref: DOID:3772 {source="MONDO:equivalentTo"} +xref: NCIT:C5273 {source="DOID:3772", source="MONDO:equivalentTo"} +xref: UMLS:C1334271 {source="NCIT:C5273", source="DOID:3772", source="MONDO:equivalentTo"} +is_a: MONDO:0000642 ! brain meningioma +is_a: MONDO:0002682 {source="DOID:3772", source="NCIT:C5273"} ! cerebral ventricle cancer +is_a: MONDO:0021322 ! malignant tumor of meninges +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0004086 ! brain ventricle +property_value: exactMatch DOID:3772 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334271 +property_value: exactMatch NCIT:C5273 +property_value: excluded_subClassOf MONDO:0003772 {source="DOID:3772"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0002776 +name: external ear disorder +def: "A disease involving the external ear." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of external ear" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of external ear" EXACT [] +synonym: "disorder of external ear" EXACT [MONDO:patterns/location_top] +synonym: "external ear disease" EXACT [MONDO:patterns/location] +synonym: "external ear disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "external ear disorder" EXACT [NCIT:C26972] +synonym: "preauricular cyst" RELATED DUBIOUS [DOID:379] +synonym: "preauricular cyst (disorder)" RELATED DUBIOUS [DOID:379] +synonym: "preauricular sinus and fistula" EXACT [DOID:379] +synonym: "preauricular sinus and fistula (disorder)" RELATED DUBIOUS [DOID:379] +synonym: "preauricular sinus or fistula" RELATED DUBIOUS [DOID:379] +synonym: "preauricular sinus or fistula NOS (disorder)" RELATED DUBIOUS [DOID:379] +xref: DOID:379 {source="MONDO:equivalentTo"} +xref: ICD10CM:H60-H62 {source="DOID:379", source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:380 {source="DOID:379"} +xref: ICD9:380.9 {source="DOID:379"} +xref: ICD9:744.47 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C26972 {source="DOID:379", source="MONDO:equivalentTo"} +xref: SCTID:49130001 {source="DOID:379", source="MONDO:equivalentTo"} +xref: UMLS:C0155388 {source="DOID:379", source="MONDO:equivalentTo"} +is_a: MONDO:0002409 {source="DOID:379"} ! auditory system disorder +is_a: MONDO:0021205 {source="MONDO:Redundant", source="NCIT:C26972"} ! disorder of ear +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001691 ! external ear +relationship: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch DOID:379 +property_value: exactMatch http://identifiers.org/snomedct/49130001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155388 +property_value: exactMatch https://icd.codes/icd10cm/H60-H62 +property_value: exactMatch NCIT:C26972 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002785 +name: skull base neoplasm +def: "A benign or malignant neoplasm that affects the skull base." [NCIT:C4676] +synonym: "basicranium neoplasm" EXACT [] +synonym: "basicranium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "basicranium tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of basicranium" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of skull base" EXACT [NCIT:C4676] +synonym: "neoplasm of the skull base" EXACT [NCIT:C4676] +synonym: "skull base cancer" RELATED [DOID:3842] +synonym: "skull base neoplasm" EXACT [NCIT:C4676] +synonym: "skull base tumor" EXACT [NCIT:C4676] +synonym: "tumor of basicranium" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of skull base" EXACT [NCIT:C4676] +synonym: "tumor of the skull base" EXACT [NCIT:C4676] +synonym: "tumors of skull base" EXACT [DOID:3842, NCIT:C4676] +xref: DOID:3842 {source="MONDO:equivalentTo"} +xref: MESH:D019292 {source="MONDO:equivalentTo", source="DOID:3842"} +xref: NCIT:C4676 {source="MONDO:equivalentTo", source="DOID:3842", source="MONDO:exact-label-match"} +xref: UMLS:C0376527 {source="MONDO:equivalentTo", source="DOID:3842", source="NCIT:C4676"} +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002517 ! basicranium +relationship: disease_has_location UBERON:0002517 ! basicranium +property_value: exactMatch DOID:3842 +property_value: exactMatch http://identifiers.org/mesh/D019292 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376527 +property_value: exactMatch NCIT:C4676 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002786 +name: diencephalic cancer +def: "A cancer involving a diencephalon." [MONDO:patterns/cancer] +synonym: "cancer of diencephalon" EXACT [MONDO:patterns/cancer] +synonym: "diencephalic neoplasm" RELATED [DOID:3843] +synonym: "diencephalon cancer" EXACT [MONDO:patterns/location] +synonym: "malignant diencephalic neoplasm" EXACT [DOID:3843, NCIT:C5126] +synonym: "malignant diencephalic neoplasms" EXACT [NCIT:C5126] +synonym: "malignant diencephalic tumor" EXACT [DOID:3843, NCIT:C5126] +synonym: "malignant diencephalon neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of diencephalon" EXACT [MONDO:patterns/cancer] +synonym: "tumor of diencephalon" EXACT [DOID:3843, NCIT:C5125] +xref: DOID:3843 {source="MONDO:equivalentTo"} +xref: NCIT:C5126 {source="DOID:3843", source="MONDO:equivalentTo"} +xref: UMLS:C1334576 {source="DOID:3843", source="MONDO:equivalentTo", source="NCIT:C5126"} +is_a: MONDO:0002071 {source="DOID:3843", source="NCIT:C5126"} ! supratentorial cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001894 ! diencephalon +relationship: disease_has_location UBERON:0001894 ! diencephalon +property_value: exactMatch DOID:3843 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334576 +property_value: exactMatch NCIT:C5126 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002790 +name: seminal vesicle tumor +def: "A benign or malignant neoplasm that affects the seminal vesicle. Representative examples include cystadenoma and adenocarcinoma." [NCIT:P378] +synonym: "neoplasm of seminal vesicle" EXACT [MONDO:patterns/neoplasm] +synonym: "seminal vesicle neoplasm" EXACT [DOID:3855, NCIT:C39908] +synonym: "seminal vesicle neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "seminal vesicle tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of seminal vesicle" EXACT [MONDO:patterns/neoplasm] +xref: DOID:3855 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C39908 {source="MONDO:equivalentTo", source="DOID:3855"} +xref: SCTID:236740006 {source="MONDO:equivalentTo", source="DOID:3855"} +xref: UMLS:C0341767 {source="NCIT:C39908", source="MONDO:equivalentTo", source="DOID:3855"} +is_a: MONDO:0021348 ! neoplasm of testis +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000998 ! seminal vesicle +relationship: disease_has_location UBERON:0000998 ! seminal vesicle +property_value: exactMatch DOID:3855 +property_value: exactMatch http://identifiers.org/snomedct/236740006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341767 +property_value: exactMatch NCIT:C39908 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002792 +name: cerebellar vermis medulloblastoma +def: "A medulloblastoma arising from the vermis of the cerebellum." [NCIT:P378] +synonym: "cerebellar vermis medulloblastoma" EXACT [MONDO:patterns/location] +synonym: "medulloblastoma of cerebellar vermis" EXACT [NCIT:C5401] +synonym: "medulloblastoma of the cerebellar vermis" EXACT [NCIT:C5401] +synonym: "vermis medulloblastoma" EXACT [DOID:3860, NCIT:C5401] +xref: DOID:3860 {source="MONDO:equivalentTo"} +xref: NCIT:C5401 {source="DOID:3860", source="MONDO:equivalentTo"} +xref: UMLS:C1332903 {source="DOID:3860", source="MONDO:equivalentTo", source="NCIT:C5401"} +is_a: MONDO:0007959 {source="DOID:3860", source="MONDO:Redundant", source="NCIT:C5401"} ! medulloblastoma +intersection_of: MONDO:0007959 ! medulloblastoma +intersection_of: disease_has_location UBERON:0004720 ! cerebellar vermis +relationship: disease_has_location UBERON:0004720 ! cerebellar vermis +property_value: exactMatch DOID:3860 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332903 +property_value: exactMatch NCIT:C5401 + +[Term] +id: MONDO:0002797 +name: childhood medulloblastoma +def: "A medulloblastoma occurring in children." [NCIT:C3997] +subset: gard_rare {source="GARD:0009350"} +synonym: "childhood medulloblastoma" EXACT [NCIT:C3997] +synonym: "medulloblastoma" BROAD [NCIT:C3997] +synonym: "medulloblastoma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "medulloblastoma, childhood" RELATED [GARD:0009350] +synonym: "pediatric medulloblastoma" EXACT [DOID:3869, MONDO:patterns/childhood, NCIT:C3997] +xref: DOID:3869 {source="MONDO:equivalentTo"} +xref: GARD:0009350 {source="MONDO:equivalentTo"} +xref: NCIT:C3997 {source="MONDO:equivalentTo", source="DOID:3869"} +xref: UMLS:C0278510 {source="MONDO:equivalentTo", source="DOID:3869", source="NCIT:C3997"} +is_a: MONDO:0003263 {source="NCIT:C3997"} ! childhood cerebellar neoplasm +is_a: MONDO:0007959 {source="DOID:3869", source="MONDO:Redundant", source="NCIT:C3997"} ! medulloblastoma +intersection_of: MONDO:0007959 ! medulloblastoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:3869 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278510 +property_value: exactMatch NCIT:C3997 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9350/medulloblastoma-childhood xsd:anyURI {source="GARD:0009350"} + +[Term] +id: MONDO:0002806 +name: bronchogenic carcinoma +def: "A lung carcinoma arising from the bronchial epithelium." [NCIT:C35875] +synonym: "BC - bronchogenic carcinoma" EXACT [DOID:3904] +synonym: "bronchial carcinoma" EXACT [NCIT:C35875] +synonym: "bronchiogenic carcinoma" EXACT [NCIT:C35875] +synonym: "bronchogenic carcinoma" EXACT [NCIT:C35875] +synonym: "bronchogenic lung cancer" EXACT [NCIT:C35875] +synonym: "bronchogenic lung carcinoma" EXACT [NCIT:C35875] +synonym: "bronchus carcinoma" EXACT [MONDO:patterns/location] +synonym: "carcinoma of bronchus" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, bronchial, malignant" EXACT [NCIT:C35875] +xref: CSP:2017-6052 {source="DOID:3904"} +xref: DOID:3904 {source="MONDO:equivalentTo"} +xref: EFO:1001942 {source="MONDO:equivalentTo"} +xref: ICD9:162.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D002283 {source="MONDO:equivalentTo", source="DOID:3904"} +xref: NCIT:C35875 {source="MONDO:equivalentTo", source="DOID:3904"} +xref: SCTID:254622008 {source="MONDO:equivalentTo", source="DOID:3904"} +xref: UMLS:C0007121 {source="MONDO:equivalentTo", source="NCIT:C35875", source="DOID:3904"} +is_a: MONDO:0001672 {source="DOID:3904", source="MONDO:Redundant"} ! bronchus cancer +is_a: MONDO:0005138 {source="EFO:1001942", source="NCIT:C35875"} ! lung carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002185 ! bronchus +relationship: disease_arises_from_structure CL:0002328 ! bronchial epithelial cell +property_value: exactMatch DOID:3904 +property_value: exactMatch http://identifiers.org/mesh/D002283 +property_value: exactMatch http://identifiers.org/snomedct/254622008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007121 +property_value: exactMatch NCIT:C35875 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002807 +name: bronchial neoplasm +def: "Tumors or cancer of the bronchi." [MESH:D001984] +synonym: "bronchial neoplasm" EXACT [MONDO:ambiguous] +synonym: "bronchial neoplasm (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "bronchus neoplasm" EXACT [DOID:3906] +synonym: "bronchus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "bronchus tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of bronchus" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of bronchus" EXACT [MONDO:patterns/neoplasm] +xref: DOID:3906 {source="MONDO:equivalentTo"} +xref: EFO:1000849 {source="MONDO:equivalentTo"} +xref: HP:0030077 {source="MONDO:otherHierarchy"} +xref: MESH:D001984 {source="MONDO:equivalentTo", source="DOID:3906"} +xref: SCTID:126705004 {source="MONDO:equivalentTo", source="DOID:3906"} +xref: UMLS:C0006264 {source="MONDO:equivalentTo", source="DOID:3906"} +is_a: MONDO:0001358 {source="DOID:3906", source="MESH:D001984", source="MONDO:Redundant"} ! bronchial disorder +is_a: MONDO:0020641 ! respiratory tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002185 ! bronchus +property_value: exactMatch DOID:3906 +property_value: exactMatch http://identifiers.org/mesh/D001984 +property_value: exactMatch http://identifiers.org/snomedct/126705004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006264 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0000589 "bronchial neoplasm (disease)" xsd:string + +[Term] +id: MONDO:0002811 +name: main bronchus cancer +def: "A malignant neoplasm involving the main bronchus." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca main bronchus" EXACT [DOID:3924] +synonym: "cancer of main bronchus" EXACT [MONDO:patterns/cancer] +synonym: "main bronchus cancer" EXACT [MONDO:patterns/location] +synonym: "malignant main bronchus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of main bronchus" EXACT [DOID:3924, ICD9CM:162.2, MONDO:patterns/cancer] +xref: DOID:3924 {source="MONDO:equivalentTo"} +xref: ICD9:162.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:3924"} +xref: SCTID:372065009 {source="MONDO:equivalentTo", source="DOID:3924"} +xref: UMLS:C0153490 {source="MONDO:equivalentTo", source="DOID:3924"} +is_a: MONDO:0001672 {source="DOID:3924", source="MONDO:Redundant"} ! bronchus cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002182 ! main bronchus +relationship: disease_has_location UBERON:0002182 ! main bronchus +property_value: exactMatch DOID:3924 +property_value: exactMatch http://identifiers.org/snomedct/372065009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153490 +property_value: excluded_subClassOf MONDO:0008903 {source="DOID:3924"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002812 +name: infectious otitis interna +def: "Inflammation of the anatomical structures of the inner ear secondary to an infectious process. Symptoms include severe vertigo, nausea, vomiting, anxiety, and pain. Viral etiology is most common, and recent history of an upper respiratory infection is common. In rare cases an infection of the middle ear can spread to the inner ear, resulting in a bacterial or fungal etiology." [NCIT:C27339] +synonym: "infectious labyrinthitis" EXACT [MONDO:cjm] +synonym: "infectious otitis interna" EXACT [NCIT:C27339] +synonym: "inner Ear infection" EXACT [NCIT:C27339] +synonym: "inner ear infection" EXACT [DOID:3930] +synonym: "internal Ear infection" EXACT [NCIT:C27339] +xref: NCIT:C27339 {source="MONDO:equivalentTo"} +xref: UMLS:C1168225 {source="MONDO:equivalentTo", source="NCIT:C27339"} +is_a: MONDO:0002008 ! labyrinthitis +is_a: MONDO:0021666 {source="MONDO:Entailed", source="NCIT:C27339"} ! ear infection +is_a: MONDO:0021669 ! post-infectious disorder +intersection_of: MONDO:0002008 ! labyrinthitis +intersection_of: disease_arises_from_feature MONDO:0005550 ! infectious disease +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1168225 +property_value: exactMatch NCIT:C27339 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml + +[Term] +id: MONDO:0002813 +name: lipomatous cancer +def: "A malignant mesenchymal neoplasm arising from adipocytes." [NCIT:C4501] +synonym: "adipose tissue cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of adipose tissue" EXACT [MONDO:patterns/cancer] +synonym: "malignant adipose tissue neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4501] +synonym: "malignant adipose tissue tumor" EXACT [NCIT:C4501] +synonym: "malignant lipomatous neoplasm" EXACT [NCIT:C4501] +synonym: "malignant lipomatous tumor" EXACT [NCIT:C4501] +synonym: "malignant neoplasm of adipose tissue" EXACT [MONDO:patterns/cancer, NCIT:C4501] +synonym: "malignant neoplasm of the adipose tissue" EXACT [NCIT:C4501] +synonym: "malignant tumor of adipose tissue" EXACT [DOID:3939, NCIT:C4501] +synonym: "malignant tumor of the adipose tissue" EXACT [NCIT:C4501] +xref: DOID:3939 {source="MONDO:equivalentObsolete"} +xref: ICD9:171.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4501 {source="MONDO:equivalentTo", source="DOID:3939"} +xref: SCTID:254828009 {source="MONDO:equivalentTo", source="DOID:3939"} +xref: UMLS:C0346117 {source="MONDO:equivalentTo", source="NCIT:C4501", source="DOID:3939"} +is_a: MONDO:0004992 ! cancer +is_a: MONDO:0021354 {source="MONDO:Redundant", source="NCIT:C4501"} ! tumor of adipose tissue +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001013 ! adipose tissue +property_value: exactMatch http://identifiers.org/snomedct/254828009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346117 +property_value: exactMatch NCIT:C4501 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002814 +name: adrenal carcinoma +def: "A carcinoma involving a adrenal gland." [MONDO:patterns/carcinoma] +synonym: "adrenal gland carcinoma" EXACT [MONDO:patterns/location] +synonym: "carcinoma of adrenal gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the adrenal gland" EXACT [DOID:3950, NCIT:C9324] +xref: DOID:3950 {source="MONDO:equivalentTo"} +is_a: MONDO:0001502 ! retroperitoneum carcinoma +is_a: MONDO:0002817 {source="DOID:3950", source="MONDO:Entailed", source="MONDO:Redundant"} ! adrenal gland cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +property_value: exactMatch DOID:3950 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002815 +name: acute myocarditis +def: "The sudden onset of inflammation of heart muscle with myocellular necrosis; this is generally secondary to an infectious cause, and patients often have a recent history of a flu-like illness." [NCIT:P378] +synonym: "myocarditis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:3951 {source="MONDO:equivalentTo"} +xref: ICD9:422 {source="DOID:3951"} +xref: ICD9:422.90 {source="DOID:3951", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:422.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C35206 {source="DOID:3951", source="MONDO:equivalentTo"} +xref: SCTID:46701001 {source="DOID:3951", source="MONDO:equivalentTo"} +xref: UMLS:C0155686 {source="DOID:3951", source="MONDO:equivalentTo", source="NCIT:C35206"} +is_a: MONDO:0004496 {source="DOID:3951", source="MONDO:Redundant", source="NCIT:C35206"} ! myocarditis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004496 ! myocarditis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:3951 +property_value: exactMatch http://identifiers.org/snomedct/46701001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155686 +property_value: exactMatch NCIT:C35206 + +[Term] +id: MONDO:0002816 +name: adrenal cortex disorder +def: "A disease involving the adrenal cortex." [https://orcid.org/0000-0002-6601-2165] +synonym: "adrenal cortex disease" EXACT [MONDO:patterns/location] +synonym: "adrenal cortex disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of adrenal cortex" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of adrenal cortex" EXACT [] +synonym: "disorder of adrenal cortex" EXACT [MONDO:patterns/location_top] +xref: DOID:3952 {source="MONDO:equivalentTo"} +xref: MESH:D000303 {source="MONDO:equivalentTo", source="DOID:3952"} +xref: SCTID:129636003 {source="MONDO:equivalentTo", source="DOID:3952"} +xref: UMLS:C0001614 {source="MONDO:equivalentTo", source="DOID:3952"} +is_a: MONDO:0005495 {source="DOID:3952", source="MESH:D000303", source="MONDO:Redundant"} ! adrenal gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001235 ! adrenal cortex +relationship: disease_has_location UBERON:0001235 ! adrenal cortex +property_value: exactMatch DOID:3952 +property_value: exactMatch http://identifiers.org/mesh/D000303 +property_value: exactMatch http://identifiers.org/snomedct/129636003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001614 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002817 +name: adrenal gland cancer +def: "A malignant neoplasm involving the adrenal gland" [https://orcid.org/0000-0002-6601-2165] +subset: gard_rare +synonym: "adrenal cancer" EXACT [DOID:3953, NCIT:C9338] +synonym: "adrenal gland cancer" EXACT [MONDO:patterns/location] +synonym: "adrenal neoplasm" BROAD [DOID:3953] +synonym: "cancer of adrenal gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant adrenal gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9338] +synonym: "malignant adrenal gland tumor" EXACT [NCIT:C9338] +synonym: "malignant adrenal neoplasm" EXACT [NCIT:C9338] +synonym: "malignant adrenal tumor" EXACT [DOID:3953, NCIT:C9338] +synonym: "malignant neoplasm of adrenal gland" EXACT [DOID:3953, ICD9CM:194.0, MONDO:patterns/cancer, NCIT:C9338] +synonym: "malignant neoplasm of the adrenal gland" EXACT [NCIT:C9338] +synonym: "malignant tumor of adrenal gland" EXACT [NCIT:C9338] +synonym: "malignant tumor of the adrenal gland" EXACT [NCIT:C9338] +synonym: "tumor of the adrenal gland" BROAD [DOID:3953, NCIT:C2859] +xref: DOID:3953 {source="MONDO:equivalentTo"} +xref: GARD:0005751 {source="MONDO:equivalentTo"} +xref: ICD9:194.0 {source="DOID:3953"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D000310 {source="DOID:3953", source="MONDO:equivalentTo"} +xref: NCIT:C9338 {source="DOID:3953", source="MONDO:equivalentTo"} +xref: SCTID:127021009 {source="DOID:3953", source="MONDO:equivalentTo"} +is_a: MONDO:0005941 {source="NCIT:C9338"} ! retroperitoneal cancer +is_a: MONDO:0021069 {source="DOID:3953", source="MESH:D000310", source="MONDO:Redundant"} ! malignant endocrine neoplasm +is_a: MONDO:0021227 {source="MONDO:Redundant", source="NCIT:C9338"} ! adrenal gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +property_value: exactMatch DOID:3953 +property_value: exactMatch http://identifiers.org/mesh/D000310 +property_value: exactMatch http://identifiers.org/snomedct/127021009 +property_value: exactMatch NCIT:C9338 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002822 +name: trabecular adenocarcinoma +def: "A malignant epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern." [NCIT:C4068] +synonym: "Merkel cell carcinoma" RELATED [DOID:3965] +synonym: "trabecula adenocarcinoma" EXACT [] +synonym: "trabecular adenocarcinoma" EXACT [NCIT:C4068] +synonym: "trabecular adenocarcinoma (morphologic abnormality)" EXACT [DOID:3965] +synonym: "trabecular carcinoma" EXACT [DOID:3965, NCIT:C4068] +xref: DOID:3965 {source="MONDO:equivalentTo"} +xref: ICDO:8190/3 {source="NCIT:C4068"} +xref: ICDO:8332/3 {source="NCIT:C4068"} +xref: NCIT:C4068 {source="MONDO:equivalentTo", source="DOID:3965"} +xref: UMLS:C0302182 {source="MONDO:equivalentTo", source="NCIT:C4068", source="DOID:3965"} +is_a: MONDO:0004970 {source="MONDO:Redundant", source="NCIT:C4068"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000440 ! trabecula +relationship: disease_has_location UBERON:0000440 ! trabecula +property_value: exactMatch DOID:3965 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0302182 +property_value: exactMatch NCIT:C4068 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0002824 +name: extrinsic cardiomyopathy +def: "A cardiomyopathy that is not due to abnormalities in heart muscle cells." [https://www.emedicinehealth.com/cardiomyopathy/article_em.htm, Wikipedia:Cardiomyopathy] +synonym: "secondary cardiomyopathy" EXACT [Wikipedia:Cardiomyopathy] +xref: DOID:3978 {source="MONDO:equivalentTo"} +xref: ICD9:425.8 {source="DOID:3978"} +xref: SCTID:195029002 {source="MONDO:equivalentTo"} +is_a: MONDO:0004994 {source="DOID:3978"} ! cardiomyopathy +property_value: exactMatch DOID:3978 +property_value: exactMatch http://identifiers.org/snomedct/195029002 + +[Term] +id: MONDO:0002828 +name: Bartholin gland transitional cell carcinoma +def: "A rare carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant urothelial-type epithelial cells." [NCIT:P378] +synonym: "Bartholin gland transitional cell carcinoma" EXACT [DOID:3998, NCIT:C40297] +synonym: "Bartholin's gland transitional cell carcinoma" EXACT [NCIT:C40297] +synonym: "major vestibular gland transitional cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3998 {source="MONDO:equivalentTo"} +xref: NCIT:C40297 {source="MONDO:equivalentTo", source="DOID:3998"} +xref: UMLS:C1511053 {source="MONDO:equivalentTo", source="DOID:3998", source="NCIT:C40297"} +is_a: MONDO:0002829 {source="DOID:3998", source="MONDO:Redundant", source="NCIT:C40297"} ! bartholin gland carcinoma +is_a: MONDO:0006474 {source="DOID:3998", source="MONDO:Redundant", source="NCIT:C40297"} ! transitional cell carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch DOID:3998 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511053 +property_value: exactMatch NCIT:C40297 + +[Term] +id: MONDO:0002829 +name: bartholin gland carcinoma +def: "A carcinoma that arises from the Bartholin gland. It usually affects women over fifty and presents with enlargement of the Bartholin gland. Various histologic subtypes have been identified and include adenocarcinoma, squamous cell carcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, transitional cell carcinoma, and small cell carcinoma." [NCIT:C9055] +synonym: "Bartholin gland cancer" EXACT [NCIT:C9055] +synonym: "bartholin gland carcinoma" EXACT [DOID:3999, MONDO:ambiguous, NCIT:C9055] +synonym: "Bartholin gland carcinoma (disease)" EXACT [MONDO:0006100] +synonym: "Bartholin's gland cancer" EXACT [DOID:3999, NCIT:C9055] +synonym: "Bartholin's gland carcinoma" EXACT [NCIT:C9055] +synonym: "carcinoma of Bartholin's gland" EXACT [DOID:3999, NCIT:C9055] +synonym: "carcinoma of major vestibular gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the Bartholin's gland" EXACT [NCIT:C9055] +synonym: "major vestibular gland carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3999 {source="MONDO:equivalentTo"} +xref: DOID:60003 {source="MONDO:equivalentTo"} +xref: EFO:1000103 {source="MONDO:equivalentTo"} +xref: HP:0030419 {source="MONDO:otherHierarchy"} +xref: NCIT:C9055 {source="MONDO:equivalentTo", source="DOID:3999", source="EFO:1000103"} +xref: SCTID:276876007 {source="MONDO:equivalentTo", source="DOID:3999"} +xref: UMLS:C0349561 {source="MONDO:equivalentTo", source="DOID:3999", source="NCIT:C9055"} +is_a: MONDO:0000653 ! integumentary system cancer +is_a: MONDO:0005215 {source="DOID:3999", source="EFO:1000103", source="MONDO:Redundant", source="NCIT:C9055"} ! vulvar carcinoma +is_a: MONDO:0021114 {source="MONDO:Redundant", source="NCIT:C9055"} ! Bartholin gland neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch DOID:3999 +property_value: exactMatch DOID:60003 +property_value: exactMatch http://identifiers.org/snomedct/276876007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349561 +property_value: exactMatch NCIT:C9055 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002833 +name: fallopian tube transitional cell carcinoma +def: "A rare transitional cell carcinoma that arises from the fallopian tube." [NCIT:C40104] +synonym: "fallopian tube transitional cell cancer" EXACT [NCIT:C40104] +synonym: "fallopian tube transitional cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C40104] +xref: DOID:4008 {source="MONDO:equivalentTo"} +xref: NCIT:C40104 {source="DOID:4008", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1517128 {source="DOID:4008", source="MONDO:equivalentTo", source="NCIT:C40104"} +is_a: MONDO:0006206 {source="DOID:4008", source="MONDO:Redundant", source="NCIT:C40104"} ! fallopian tube carcinoma +is_a: MONDO:0006474 {source="DOID:4008", source="MONDO:Redundant", source="NCIT:C40104"} ! transitional cell carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:4008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1517128 +property_value: exactMatch NCIT:C40104 + +[Term] +id: MONDO:0002834 +name: primary prostate urothelial carcinoma +def: "An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts or the prostatic urethra." [NCIT:C39898] +synonym: "primary prostate urothelial cancer" EXACT [NCIT:C39898] +synonym: "primary prostate urothelial carcinoma" EXACT [NCIT:C39898] +synonym: "prostate gland transitional cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "prostate transitional cell carcinoma" EXACT [NCIT:C39898] +synonym: "prostate urothelial carcinoma" EXACT [NCIT:C39898] +synonym: "transitional cell carcinoma of prostate" EXACT [DOID:4011, NCIT:C39898, NCIT:C5540] +synonym: "transitional cell carcinoma of the prostate" EXACT [NCIT:C39898] +xref: DOID:4011 {source="MONDO:equivalentTo"} +xref: NCIT:C39898 {source="MONDO:equivalentTo"} +xref: UMLS:C1514430 {source="MONDO:equivalentTo", source="NCIT:C39898"} +is_a: MONDO:0005159 {source="DOID:4011", source="MONDO:Redundant", source="NCIT:C39898"} ! prostate carcinoma +is_a: MONDO:0006474 {source="DOID:4011", source="MONDO:0002834/inferred", source="MONDO:Entailed", source="NCIT:C39898/inferred"} ! transitional cell carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:4011 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514430 +property_value: exactMatch NCIT:C39898 + +[Term] +id: MONDO:0002836 +name: urethra transitional cell carcinoma +def: "A transitional cell carcinoma that arises from the male or female urethra." [NCIT:P378] +synonym: "transitional cell carcinoma of the urethra" EXACT [NCIT:C6166] +synonym: "transitional cell carcinoma of urethra" EXACT [NCIT:C6166] +synonym: "UCU" RELATED ABBREVIATION [ONCOTREE:UCU] +synonym: "urethra transitional cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "urethral transitional cell carcinoma" EXACT [DOID:4013, NCIT:C6166] +synonym: "urethral urothelial cancer" EXACT [NCIT:C6166] +synonym: "urethral urothelial carcinoma" EXACT [NCIT:C6166] +xref: DOID:4013 {source="MONDO:equivalentTo"} +xref: NCIT:C6166 {source="DOID:4013", source="MONDO:equivalentTo"} +xref: ONCOTREE:UCU {source="MONDO:equivalentTo"} +xref: UMLS:C0863015 {source="DOID:4013", source="NCIT:C6166", source="MONDO:equivalentTo"} +is_a: MONDO:0021327 {source="MONDO:Redundant", source="NCIT:C6166"} ! carcinoma of urethra +is_a: MONDO:0040679 ! urothelial carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:4013 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0863015 +property_value: exactMatch NCIT:C6166 + +[Term] +id: MONDO:0002842 +name: bacterial gastritis +def: "Gastritis resulting from bacteria." [NCIT:C27340] +synonym: "Bacteria caused gastritis (disease)" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria gastritis (disease)" EXACT [] +synonym: "bacterial gastritis" EXACT [NCIT:C27340] +xref: DOID:4033 {source="MONDO:equivalentTo"} +xref: NCIT:C27340 {source="MONDO:equivalentTo", source="DOID:4033"} +xref: SCTID:723096000 {source="MONDO:equivalentTo"} +xref: UMLS:C0948039 {source="NCIT:C27340", source="MONDO:equivalentTo", source="DOID:4033"} +is_a: MONDO:0004966 {source="DOID:4033", source="MONDO:Redundant", source="NCIT:C27340"} ! gastritis +is_a: MONDO:0005113 ! bacterial infectious disease +is_a: MONDO:0043424 ! digestive system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +intersection_of: disease_has_inflammation_site UBERON:0000945 ! stomach +property_value: exactMatch DOID:4033 +property_value: exactMatch http://identifiers.org/snomedct/723096000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0948039 +property_value: exactMatch NCIT:C27340 + +[Term] +id: MONDO:0002847 +name: skeletal muscle cancer +def: "A malignant neoplasm arising from skeletal muscle." [NCIT:P378] +synonym: "cancer of skeletal muscle tissue" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of skeletal muscle" EXACT [NCIT:C6516] +synonym: "malignant neoplasm of skeletal muscle tissue" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the skeletal muscle" EXACT [NCIT:C6516] +synonym: "malignant skeletal muscle neoplasm" EXACT [NCIT:C6516] +synonym: "malignant skeletal muscle tissue neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant skeletal muscle tumor" EXACT [NCIT:C6516] +synonym: "malignant tumor of skeletal muscle" EXACT [DOID:4043, NCIT:C6516] +synonym: "malignant tumor of the skeletal muscle" EXACT [NCIT:C6516] +synonym: "skeletal muscle tissue cancer" EXACT [MONDO:patterns/location] +xref: DOID:4043 {source="MONDO:equivalentTo"} +xref: NCIT:C6516 {source="MONDO:equivalentTo", source="DOID:4043"} +xref: UMLS:C1334619 {source="MONDO:equivalentTo", source="NCIT:C6516", source="DOID:4043"} +is_a: MONDO:0002848 {source="MONDO:Redundant", source="NCIT:C6516"} ! skeletal muscle neoplasm +is_a: MONDO:0005864 {source="DOID:4043", source="MONDO:Redundant", source="NCIT:C6516"} ! muscle cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001134 ! skeletal muscle tissue +property_value: exactMatch DOID:4043 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334619 +property_value: exactMatch NCIT:C6516 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002848 +name: skeletal muscle neoplasm +def: "A benign or malignant mesenchymal neoplasm arising from skeletal muscle." [NCIT:C6514] +synonym: "neoplasm of skeletal muscle" EXACT [NCIT:C6514] +synonym: "neoplasm of skeletal muscle tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the skeletal muscle" EXACT [NCIT:C6514] +synonym: "skeletal muscle neoplasm" EXACT [NCIT:C6514] +synonym: "skeletal muscle tissue neoplasm" EXACT [] +synonym: "skeletal muscle tissue neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "skeletal muscle tissue tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "skeletal muscle tumor" EXACT [NCIT:C6514] +synonym: "tumor of skeletal muscle" EXACT [DOID:4044, NCIT:C6514] +synonym: "tumor of skeletal muscle tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the skeletal muscle" EXACT [NCIT:C6514] +xref: DOID:4044 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6514 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4044"} +xref: SCTID:699955004 {source="MONDO:equivalentTo", source="DOID:4044"} +xref: UMLS:C1335971 {source="MONDO:equivalentTo", source="NCIT:C6514", source="DOID:4044"} +is_a: MONDO:0005070 ! neoplasm +is_a: MONDO:0020120 {source="MONDO:Redundant"} ! skeletal muscle disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001134 ! skeletal muscle tissue +property_value: exactMatch DOID:4044 +property_value: exactMatch http://identifiers.org/snomedct/699955004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335971 +property_value: exactMatch NCIT:C6514 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002866 +name: duodenal disorder +def: "Pathological conditions in the duodenum region of the small intestine (intestine, small)." [MESH:D004378] +synonym: "disease of duodenum" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of duodenum" EXACT [] +synonym: "disorder of duodenum" EXACT [MONDO:patterns/location_top] +synonym: "duodenum disease" EXACT [MONDO:patterns/location] +synonym: "duodenum disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "duodenum disorder" EXACT [DOID:4072] +xref: DOID:4072 {source="MONDO:equivalentTo"} +xref: ICD9:537.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:537.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D004378 {source="MONDO:equivalentTo", source="DOID:4072"} +xref: SCTID:52182008 {source="MONDO:equivalentTo", source="DOID:4072"} +xref: UMLS:C0013289 {source="MONDO:equivalentTo", source="DOID:4072"} +is_a: MONDO:0024635 ! small intestine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002114 ! duodenum +relationship: disease_has_location UBERON:0002114 ! duodenum +property_value: exactMatch DOID:4072 +property_value: exactMatch http://identifiers.org/mesh/D004378 +property_value: exactMatch http://identifiers.org/snomedct/52182008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013289 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002869 +name: heart valve disorder +def: "A disease involving the cardial valve." [https://orcid.org/0000-0002-6601-2165] +synonym: "cardial valve disease" EXACT [MONDO:patterns/location] +synonym: "cardial valve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of cardial valve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cardial valve" EXACT [] +synonym: "disorder of cardial valve" EXACT [MONDO:patterns/location_top] +synonym: "disorder of heart valve" EXACT [NCIT:C45525] +synonym: "heart valve disorder" EXACT [NCIT:C45525] +synonym: "valvular heart disease" EXACT [DOID:4079] +synonym: "valvular heart disorder" EXACT [NCIT:C45525] +xref: DOID:4079 {source="MONDO:equivalentTo"} +xref: ICD9:424.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006349 {source="DOID:4079", source="MONDO:equivalentTo"} +xref: NCIT:C45525 {source="DOID:4079", source="MONDO:equivalentTo"} +xref: SCTID:368009 {source="DOID:4079", source="MONDO:equivalentTo"} +xref: UMLS:C0018824 {source="DOID:4079", source="MONDO:equivalentTo", source="NCIT:C45525"} +is_a: MONDO:0005267 {source="DOID:4079", source="MESH:D006349", source="MONDO:Redundant", source="NCIT:C45525/inferred"} ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000946 ! cardial valve +relationship: disease_has_location UBERON:0000946 ! cardial valve +property_value: exactMatch DOID:4079 +property_value: exactMatch http://identifiers.org/mesh/D006349 +property_value: exactMatch http://identifiers.org/snomedct/368009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018824 +property_value: exactMatch NCIT:C45525 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002871 +name: testicular trophoblastic tumor +def: "A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas." [NCIT:C39934] +synonym: "testicular trophoblastic tumor" EXACT [NCIT:C39934] +xref: DOID:4084 {source="MONDO:equivalentTo"} +xref: NCIT:C39934 {source="MONDO:equivalentTo", source="DOID:4084", source="MONDO:exact-label-match"} +xref: UMLS:C1515301 {source="MONDO:equivalentTo", source="DOID:4084", source="NCIT:C39934"} +is_a: MONDO:0002872 {source="DOID:4084", source="MONDO:Redundant", source="NCIT:C39934"} ! trophoblastic neoplasm +is_a: MONDO:0002874 {source="NCIT:C39934"} ! testicular pure germ cell tumor +is_a: MONDO:0006447 {source="NCIT:C39934"} ! testicular non-seminomatous germ cell tumor +intersection_of: MONDO:0002872 ! trophoblastic neoplasm +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:4084 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1515301 +property_value: exactMatch NCIT:C39934 + +[Term] +id: MONDO:0002872 +name: trophoblastic neoplasm +def: "A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells. Representative examples include hydatidiform mole and choriocarcinoma." [NCIT:C3422] +synonym: "neoplasm of trophoblast" EXACT [MONDO:patterns/neoplasm] +synonym: "trophoblast neoplasm" EXACT [] +synonym: "trophoblast neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "trophoblast tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "trophoblastic neoplasm" EXACT [NCIT:C3422] +synonym: "trophoblastic neoplasm (morphologic abnormality)" EXACT [DOID:4085] +synonym: "trophoblastic neoplasm NOS (morphologic abnormality)" EXACT [DOID:4085] +synonym: "trophoblastic neoplasms" EXACT [NCIT:C3422] +synonym: "trophoblastic tumor" EXACT [DOID:4085, NCIT:C3422] +synonym: "trophoblastic tumor (qualifier value)" EXACT [DOID:4085] +synonym: "tumor of trophoblast" EXACT [MONDO:patterns/neoplasm] +xref: DOID:4085 {source="MONDO:equivalentTo"} +xref: MESH:D014328 {source="MONDO:equivalentTo", source="DOID:4085"} +xref: NCIT:C3422 {source="MONDO:equivalentTo"} +xref: UMLS:C0041182 {source="MONDO:equivalentTo", source="NCIT:C3422", source="DOID:4085"} +is_a: MONDO:0005070 ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000088 ! trophoblast +relationship: disease_has_location UBERON:0000088 ! trophoblast +property_value: exactMatch DOID:4085 +property_value: exactMatch http://identifiers.org/mesh/D014328 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0041182 +property_value: exactMatch NCIT:C3422 +property_value: excluded_subClassOf MONDO:0002510 {source="DOID:4085", source="MESH:D014328"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002874 +name: testicular pure germ cell tumor +def: "A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and trophoblastic tumor." [NCIT:C39915] +synonym: "testicular Pure germ cell tumor" EXACT [NCIT:C39915] +xref: DOID:4087 {source="MONDO:equivalentTo"} +xref: NCIT:C39915 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4087"} +xref: UMLS:C1514608 {source="MONDO:equivalentTo", source="NCIT:C39915", source="DOID:4087"} +is_a: MONDO:0010108 {source="DOID:4087", source="NCIT:C39915"} ! testicular germ cell tumor +property_value: exactMatch DOID:4087 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514608 +property_value: exactMatch NCIT:C39915 + +[Term] +id: MONDO:0002882 +name: colon neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the colon. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5697] +synonym: "colon NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "colon neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5697] +synonym: "colon neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "colon neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "colonic neuroendocrine neoplasm" EXACT [NCIT:C5697] +synonym: "colonic neuroendocrine tumor" EXACT [DOID:4118, NCIT:C5697] +synonym: "neuroendocrine neoplasm of colon" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5697] +synonym: "neuroendocrine neoplasm of the colon" EXACT [NCIT:C5697] +synonym: "neuroendocrine tumor of the colon" RELATED [Orphanet:100080] +xref: DOID:4118 {source="MONDO:equivalentTo"} +xref: NCIT:C5697 {source="DOID:4118", source="MONDO:equivalentTo"} +xref: Orphanet:100080 {source="MONDO:equivalentTo"} +xref: UMLS:C1333097 {source="DOID:4118", source="MONDO:equivalentTo", source="NCIT:C5697"} +is_a: MONDO:0002883 {source="DOID:4118", source="MONDO:Redundant", source="NCIT:C5697/inferred"} ! intestinal neuroendocrine neoplasm +is_a: MONDO:0005401 {source="MONDO:Redundant", source="NCIT:C5697"} ! colonic neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:4118 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333097 +property_value: exactMatch NCIT:C5697 +property_value: exactMatch Orphanet:100080 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0002883 +name: intestinal neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the small or large intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5695] +synonym: "intestinal neuroendocrine benign tumor" RELATED [DOID:4119] +synonym: "intestinal neuroendocrine neoplasm" EXACT [NCIT:C5695] +synonym: "intestine NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "intestine neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "intestine neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "intestine neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of intestine" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5695] +synonym: "neuroendocrine neoplasm of the intestine" EXACT [NCIT:C5695] +synonym: "neuroendocrine tumor of intestine" EXACT [DOID:4119] +xref: DOID:4119 {source="MONDO:equivalentTo"} +xref: NCIT:C5695 {source="MONDO:equivalentTo", source="DOID:4119"} +xref: UMLS:C1334231 {source="NCIT:C5695", source="MONDO:equivalentTo", source="DOID:4119"} +is_a: MONDO:0021118 {source="DOID:4119", source="MONDO:Redundant", source="NCIT:C5695"} ! intestinal neoplasm +is_a: MONDO:0024503 ! digestive system neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000160 ! intestine +property_value: exactMatch DOID:4119 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334231 +property_value: exactMatch NCIT:C5695 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0002884 +name: nail disorder +def: "A disease involving the nail." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of nail" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nail" EXACT [] +synonym: "disorder of nail" EXACT [MONDO:patterns/location_top] +synonym: "nail disease" EXACT [MONDO:patterns/location] +synonym: "nail disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:4123 {source="MONDO:equivalentTo"} +xref: ICD9:703 {source="DOID:4123"} +xref: ICD9:703.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:703.9 {source="DOID:4123", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009260 {source="DOID:4123", source="MONDO:equivalentTo"} +xref: SCTID:17790008 {source="DOID:4123", source="MONDO:equivalentTo"} +xref: UMLS:C0027339 {source="DOID:4123", source="MONDO:equivalentTo"} +is_a: MONDO:0002051 {source="DOID:4123", source="MONDO:Redundant"} ! integumentary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001705 ! nail +relationship: disease_has_location UBERON:0001705 ! nail +property_value: exactMatch DOID:4123 +property_value: exactMatch http://identifiers.org/mesh/D009260 +property_value: exactMatch http://identifiers.org/snomedct/17790008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027339 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002886 +name: common bile duct disorder +def: "A disease involving the common bile duct." [https://orcid.org/0000-0002-6601-2165] +synonym: "common bile duct disease" EXACT [MONDO:patterns/location] +synonym: "common bile duct disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of common bile duct" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of common bile duct" EXACT [] +synonym: "disorder of common bile duct" EXACT [MONDO:patterns/location_top] +xref: DOID:4137 {source="MONDO:equivalentTo"} +xref: MESH:D003137 {source="DOID:4137", source="MONDO:equivalentTo"} +xref: UMLS:C0009440 {source="DOID:4137", source="MONDO:equivalentTo"} +is_a: MONDO:0002887 {source="DOID:4137", source="MESH:D003137", source="MONDO:Entailed", source="MONDO:Redundant"} ! bile duct disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001174 ! common bile duct +relationship: disease_has_location UBERON:0001174 ! common bile duct +property_value: exactMatch DOID:4137 +property_value: exactMatch http://identifiers.org/mesh/D003137 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009440 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002887 +name: bile duct disorder +def: "A disease involving the bile duct." [https://orcid.org/0000-0002-6601-2165] +synonym: "bile duct disease" EXACT [MONDO:patterns/location] +synonym: "bile duct disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "bile duct disorder" EXACT [NCIT:C96716] +synonym: "disease of bile duct" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of bile duct" EXACT [] +synonym: "disorder of bile duct" EXACT [MONDO:patterns/location_top] +xref: DOID:4138 {source="MONDO:equivalentTo"} +xref: MESH:D001649 {source="DOID:4138", source="MONDO:equivalentTo"} +xref: NCIT:C96716 {source="DOID:4138", source="MONDO:equivalentTo"} +xref: SCTID:118926004 {source="DOID:4138", source="MONDO:equivalentTo"} +xref: UMLS:C0005395 {source="DOID:4138", source="NCIT:C96716", source="MONDO:equivalentTo"} +is_a: MONDO:0004868 {source="DOID:4138", source="MESH:D001649", source="MONDO:Redundant"} ! biliary tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002394 ! bile duct +relationship: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch DOID:4138 +property_value: exactMatch http://identifiers.org/mesh/D001649 +property_value: exactMatch http://identifiers.org/snomedct/118926004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005395 +property_value: exactMatch NCIT:C96716 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002889 +name: orbital cancer +def: "A primary or metastatic malignant neoplasm involving the orbit." [NCIT:P378] +synonym: "cancer of orbit of skull" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of orbit" EXACT [DOID:4143, ICD9CM:190.1] +synonym: "malignant neoplasm of orbit of skull" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the orbit" EXACT [NCIT:C3562] +synonym: "malignant orbit neoplasm" EXACT [NCIT:C3562] +synonym: "malignant orbit of skull neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant orbit tumor" EXACT [NCIT:C3562] +synonym: "malignant orbital neoplasm" EXACT [NCIT:C3562] +synonym: "malignant orbital tumor" EXACT [NCIT:C3562] +synonym: "malignant tumor of orbit" EXACT [NCIT:C3562] +synonym: "malignant tumor of the orbit" EXACT [NCIT:C3562] +synonym: "neoplasm of orbit proper" BROAD [DOID:4143] +synonym: "orbit cancer" EXACT [DOID:4143] +synonym: "orbit of skull cancer" EXACT [MONDO:patterns/location] +synonym: "orbital tumor" BROAD [DOID:4143, NCIT:C3290] +xref: DOID:4143 {source="MONDO:equivalentTo"} +xref: EFO:0007408 {source="MONDO:equivalentTo"} +xref: ICD9:190.1 {source="DOID:4143"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3562 {source="MONDO:equivalentTo", source="DOID:4143"} +xref: SCTID:127003006 {source="MONDO:equivalentTo", source="DOID:4143"} +is_a: MONDO:0002132 ! skull cancer +is_a: MONDO:0024611 ! orbit neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001697 ! orbit of skull +relationship: disease_has_feature HP:0000520 ! Proptosis +property_value: exactMatch DOID:4143 +property_value: exactMatch http://identifiers.org/snomedct/127003006 +property_value: exactMatch NCIT:C3562 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002898 +name: skin cancer +def: "A malignant neoplasm involving the zone of skin" [https://orcid.org/0000-0002-6601-2165] +synonym: "CA - skin cancer" EXACT [DOID:4159] +synonym: "cancer of skin" RELATED [DOID:4159] +synonym: "cancer of zone of skin" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of skin" EXACT [DOID:4159, MTH:NOCODE, NCIT:C2920] +synonym: "malignant neoplasm of the skin" EXACT [NCIT:C2920] +synonym: "malignant neoplasm of zone of skin" EXACT [MONDO:patterns/cancer] +synonym: "malignant skin neoplasm" EXACT [NCIT:C2920] +synonym: "malignant skin tumor" EXACT [NCIT:C2920] +synonym: "malignant tumor of skin" EXACT [NCIT:C2920] +synonym: "malignant tumor of the skin" EXACT [NCIT:C2920] +synonym: "malignant zone of skin neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "melanoma and non-melanoma skin cancer" EXACT [DOID:4159, NCIT:C2920] +synonym: "skin cancer" EXACT [NCIT:C2920] +synonym: "skin cancer, Including melanoma" EXACT [NCIT:C2920] +synonym: "skin neoplasm, malignant" EXACT [NCIT:C2920] +synonym: "zone of skin cancer" EXACT [MONDO:patterns/location] +xref: DOID:4159 {source="MONDO:equivalentTo"} +xref: GARD:0010421 {source="MONDO:equivalentTo"} +xref: ICD10CM:C43-C44 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:173.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:173.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C2920 {source="DOID:4159", source="MONDO:equivalentTo"} +xref: SCTID:372130007 {source="DOID:4159", source="MONDO:equivalentTo"} +xref: UMLS:C0007114 {source="DOID:4159", source="MONDO:equivalentTo", source="NCIT:C2920"} +is_a: MONDO:0000653 {source="DOID:4159", source="MONDO:Entailed", source="MONDO:Redundant"} ! integumentary system cancer +is_a: MONDO:0002531 {source="MONDO:Redundant", source="NCIT:C2920"} ! skin neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:4159 +property_value: exactMatch http://identifiers.org/snomedct/372130007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007114 +property_value: exactMatch https://icd.codes/icd10cm/C43-C44 +property_value: exactMatch NCIT:C2920 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002908 +name: glucose metabolism disease +def: "A metabolic disorder characterized by abnormal blood glucose levels." [NCIT:P378] +synonym: "disorder of glucose metabolism" EXACT [NCIT:C53655] +synonym: "glucose metabolism disorder" EXACT [NCIT:C53655] +xref: DOID:4194 {source="MONDO:equivalentTo"} +xref: ICD9:271.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D044882 {source="MONDO:equivalentTo", source="DOID:4194"} +xref: NCIT:C53655 {source="MONDO:equivalentTo", source="DOID:4194"} +xref: SCTID:126877002 {source="MONDO:equivalentTo", source="DOID:4194"} +xref: UMLS:C1257958 {source="MONDO:equivalentTo", source="DOID:4194", source="NCIT:C53655"} +is_a: MONDO:0005066 {source="DOID:4194/inferred", source="MESH:D044882", source="MONDO:Redundant", source="NCIT:C53655/inferred"} ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_disrupts GO:0006006 ! glucose metabolic process +relationship: disease_disrupts GO:0006006 ! glucose metabolic process +property_value: exactMatch DOID:4194 +property_value: exactMatch http://identifiers.org/mesh/D044882 +property_value: exactMatch http://identifiers.org/snomedct/126877002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1257958 +property_value: exactMatch NCIT:C53655 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0002909 +name: hyperglycemia +def: "Abnormally high level of glucose in the blood." [NCIT:P378] +xref: DOID:4195 {source="MONDO:equivalentTo"} +xref: ICD9:790.6 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006943 {source="MONDO:equivalentTo", source="DOID:4195"} +xref: NCIT:C26797 {source="MONDO:otherHierarchy", source="DOID:4195"} +xref: SCTID:80394007 {source="MONDO:equivalentTo", source="DOID:4195"} +xref: UMLS:C0020456 {source="MONDO:equivalentTo", source="DOID:4195"} +is_a: MONDO:0002908 {source="DOID:4195", source="MESH:D006943", source="MONDO:Redundant"} ! glucose metabolism disease +intersection_of: MONDO:0002908 ! glucose metabolism disease +intersection_of: disease_has_feature HP:0003074 ! Hyperglycemia +relationship: disease_has_feature HP:0003074 ! Hyperglycemia +property_value: exactMatch DOID:4195 +property_value: exactMatch http://identifiers.org/mesh/D006943 +property_value: exactMatch http://identifiers.org/snomedct/80394007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020456 +property_value: relatedMatch NCIT:C26797 + +[Term] +id: MONDO:0002911 +name: brain stem glioma +def: "A neuroglial tumor that arises from the brain stem." [NCIT:C8501] +synonym: "brain stem glioma" EXACT [NCIT:C8501] +synonym: "brain stem neuroglial neoplasm" EXACT [NCIT:C8501] +synonym: "brain stem neuroglial tumor" EXACT [NCIT:C8501] +synonym: "brainstem glioma" EXACT [NCIT:C8501] +synonym: "brainstem malignant glioma" EXACT [MONDO:patterns/location] +synonym: "brainstem neuroglial neoplasm" EXACT [NCIT:C8501] +synonym: "brainstem neuroglial tumor" EXACT [DOID:4202, NCIT:C8501] +synonym: "diffuse brainstem glioma" EXACT [NCIT:C8501] +synonym: "glioma of brain stem" EXACT [NCIT:C8501] +synonym: "glioma of brainstem" EXACT [NCIT:C8501] +synonym: "glioma of the brain stem" EXACT [NCIT:C8501] +synonym: "glioma of the brainstem" EXACT [NCIT:C8501] +synonym: "malignant glioma of brainstem" EXACT [MONDO:design_pattern] +xref: DOID:4202 {source="MONDO:equivalentTo"} +xref: NCIT:C8501 {source="DOID:4202", source="MONDO:equivalentTo"} +xref: SCTID:444545003 {source="DOID:4202", source="MONDO:equivalentTo"} +xref: UMLS:C0677865 {source="DOID:4202", source="MONDO:equivalentTo", source="NCIT:C8501"} +is_a: MONDO:0002912 {source="DOID:4202", source="MONDO:Entailed", source="MONDO:Redundant"} ! brainstem cancer +is_a: MONDO:0005499 {source="DOID:4202", source="MONDO:Redundant"} ! brain glioma +intersection_of: MONDO:0100342 ! malignant glioma +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch DOID:4202 +property_value: exactMatch http://identifiers.org/snomedct/444545003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0677865 +property_value: exactMatch NCIT:C8501 + +[Term] +id: MONDO:0002912 +name: brainstem cancer +def: "A primary or metastatic malignant neoplasm that affects the brain stem." [NCIT:C3570] +subset: gard_rare {source="GARD:0008244"} +synonym: "brain stem cancer" RELATED [DOID:4203, GARD:0008244] +synonym: "brainstem cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of brainstem" EXACT [MONDO:patterns/cancer] +synonym: "malignant brain stem neoplasm" BROAD [NCIT:C3570] +synonym: "malignant brain stem tumor" BROAD [NCIT:C3570] +synonym: "malignant brainstem neoplasm" BROAD [MONDO:patterns/cancer, NCIT:C3570] +synonym: "malignant brainstem tumor" BROAD [NCIT:C3570] +synonym: "malignant neoplasm of brain stem" EXACT [DOID:4203, NCIT:C3570] +synonym: "malignant neoplasm of brainstem" EXACT [DOID:4203, MONDO:patterns/cancer, NCIT:C3570] +synonym: "malignant neoplasm of the brain stem" EXACT [NCIT:C3570] +synonym: "malignant neoplasm of the brainstem" EXACT [NCIT:C3570] +synonym: "malignant tumor of brain stem" EXACT [NCIT:C3570] +synonym: "malignant tumor of brainstem" EXACT [DOID:4203, NCIT:C3570] +synonym: "malignant tumor of the brain stem" EXACT [NCIT:C3570] +synonym: "malignant tumor of the brainstem" EXACT [NCIT:C3570] +synonym: "neoplasm of adult brain stem" BROAD [DOID:4203] +synonym: "neoplasm of brain stem" BROAD [DOID:4203] +synonym: "primary brain stem neoplasm" BROAD [DOID:4203] +synonym: "primary brain stem tumor" BROAD [DOID:4203] +synonym: "tumor of the brainstem" BROAD [DOID:4203] +xref: DOID:4203 {source="MONDO:equivalentTo"} +xref: GARD:0008244 {source="MONDO:equivalentTo"} +xref: ICD9:191.7 {source="DOID:4203", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D020295 {source="DOID:4203", source="MONDO:equivalentTo"} +xref: NCIT:C3570 {source="DOID:4203", source="MONDO:equivalentTo"} +xref: NCIT:C5967 {source="DOID:4203", source="MONDO:directSiblingOf"} +xref: SCTID:363473003 {source="DOID:4203", source="MONDO:equivalentTo"} +xref: UMLS:C1332192 {source="DOID:4203", source="MONDO:directSiblingOf"} +is_a: MONDO:0003107 {source="DOID:4203", source="MESH:D020295", source="NCIT:C3570"} ! infratentorial cancer +is_a: MONDO:0021228 {source="MONDO:Redundant", source="NCIT:C3570"} ! brainstem neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch DOID:4203 +property_value: exactMatch http://identifiers.org/mesh/D020295 +property_value: exactMatch http://identifiers.org/snomedct/363473003 +property_value: exactMatch NCIT:C3570 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/8244/brain-stem-cancer xsd:anyURI {source="GARD:0008244"} + +[Term] +id: MONDO:0002913 +name: cerebellar neoplasm +def: "A benign or malignant (primary or metastatic) tumor involving the cerebellum. -- 2003" [NCIT:C2935] +synonym: "cerebellar neoplasm" EXACT [NCIT:C2935] +synonym: "cerebellar tumor" EXACT [NCIT:C2935] +synonym: "cerebellum cancer" RELATED [DOID:4205] +synonym: "cerebellum neoplasm" EXACT [] +synonym: "cerebellum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "cerebellum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "malignant tumor of cerebellum" NARROW [DOID:4205, NCIT:C3569] +synonym: "neoplasm of cerebellum" EXACT [MONDO:patterns/neoplasm, NCIT:C2935] +synonym: "neoplasm of the cerebellum" EXACT [NCIT:C2935] +synonym: "tumor of cerebellum" EXACT [MONDO:patterns/neoplasm, NCIT:C2935] +synonym: "tumor of the cerebellum" EXACT [NCIT:C2935] +xref: DOID:4205 {source="MONDO:equivalentTo"} +xref: ICD9:191.6 {source="DOID:4205"} +xref: MESH:D002528 {source="MONDO:equivalentTo", source="DOID:4205"} +xref: NCIT:C2935 {source="MONDO:equivalentTo", source="DOID:4205"} +xref: SCTID:126960003 {source="MONDO:equivalentTo", source="DOID:4205"} +xref: UMLS:C0007762 {source="NCIT:C2935", source="MONDO:equivalentTo", source="DOID:4205"} +is_a: MONDO:0002427 {source="MESH:D002528", source="MONDO:Redundant"} ! cerebellar disorder +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C2935/inferred"} ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch DOID:4205 +property_value: exactMatch http://identifiers.org/mesh/D002528 +property_value: exactMatch http://identifiers.org/snomedct/126960003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007762 +property_value: exactMatch NCIT:C2935 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0002914 +name: childhood brain stem neoplasm +def: "A neoplasm that affects the brain stem and occurs during childhood." [NCIT:C5969] +synonym: "brain stem neoplasm" EXACT [NCIT:C5969] +synonym: "brainstem cancer of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "childhood brain stem neoplasm" EXACT [NCIT:C5969] +synonym: "childhood brain stem tumor" EXACT [NCIT:C5969] +synonym: "childhood brainstem cancer" EXACT [MONDO:design_pattern] +synonym: "childhood brainstem neoplasm" EXACT [NCIT:C5969] +synonym: "childhood brainstem tumor" EXACT [NCIT:C5969] +synonym: "childhood neoplasm of brain stem" EXACT [NCIT:C5969] +synonym: "childhood neoplasm of brainstem" EXACT [NCIT:C5969] +synonym: "childhood neoplasm of the brain stem" EXACT [NCIT:C5969] +synonym: "childhood neoplasm of the brainstem" EXACT [NCIT:C5969] +synonym: "childhood tumor of brain stem" EXACT [NCIT:C5969] +synonym: "childhood tumor of brainstem" EXACT [NCIT:C5969] +synonym: "childhood tumor of the brain stem" EXACT [NCIT:C5969] +synonym: "childhood tumor of the brainstem" EXACT [NCIT:C5969] +synonym: "pediatric brain stem neoplasm" EXACT [NCIT:C5969] +synonym: "pediatric brain stem tumor" EXACT [NCIT:C5969] +synonym: "pediatric brainstem cancer" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric brainstem neoplasm" EXACT [NCIT:C5969] +synonym: "pediatric brainstem tumor" EXACT [NCIT:C5969] +synonym: "pediatric neoplasm of brain stem" EXACT [NCIT:C5969] +synonym: "pediatric neoplasm of brainstem" EXACT [NCIT:C5969] +synonym: "pediatric neoplasm of the brain stem" EXACT [NCIT:C5969] +synonym: "pediatric neoplasm of the brainstem" EXACT [NCIT:C5969] +synonym: "pediatric tumor of brain stem" EXACT [NCIT:C5969] +synonym: "pediatric tumor of brainstem" EXACT [DOID:4206, NCIT:C5969] +synonym: "pediatric tumor of the brain stem" EXACT [NCIT:C5969] +synonym: "pediatric tumor of the brainstem" EXACT [NCIT:C5969] +xref: DOID:4206 {source="MONDO:equivalentTo"} +xref: EFO:1001767 {source="MONDO:equivalentTo"} +xref: NCIT:C5969 {source="DOID:4206", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332951 {source="DOID:4206", source="MONDO:equivalentTo", source="NCIT:C5969"} +is_a: MONDO:0002912 {source="DOID:4206", source="MONDO:Redundant"} ! brainstem cancer +is_a: MONDO:0002915 {source="NCIT:C5969"} ! childhood infratentorial neoplasm +is_a: MONDO:0006517 ! childhood malignant neoplasm +intersection_of: MONDO:0002912 ! brainstem cancer +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:4206 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332951 +property_value: exactMatch NCIT:C5969 + +[Term] +id: MONDO:0002915 +name: childhood infratentorial neoplasm +def: "A neoplasm that affects the infratentorial region of the brain and occurs during childhood." [NCIT:C5802] +synonym: "childhood infratentorial neoplasm" EXACT [NCIT:C5802] +synonym: "childhood infratentorial neoplasms" EXACT [NCIT:C5802] +synonym: "childhood infratentorial tumor" EXACT [NCIT:C5802] +synonym: "childhood infratentorial tumors" EXACT [NCIT:C5802] +synonym: "infratentorial neoplasm of childhood" EXACT [MONDO:patterns/childhood] +synonym: "pediatric infratentorial neoplasm" EXACT [MONDO:patterns/childhood, NCIT:C5802] +synonym: "pediatric infratentorial tumor" EXACT [DOID:4207, NCIT:C5802] +xref: DOID:4207 {source="MONDO:equivalentTo"} +xref: NCIT:C5802 {source="MONDO:equivalentTo", source="DOID:4207", source="MONDO:exact-label-match"} +xref: UMLS:C1332973 {source="MONDO:equivalentTo", source="DOID:4207", source="NCIT:C5802"} +is_a: MONDO:0021079 ! childhood neoplasm +is_a: MONDO:0037736 ! infratentorial neoplasm +intersection_of: MONDO:0037736 ! infratentorial neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:4207 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332973 +property_value: exactMatch NCIT:C5802 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0002912 {source="DOID:4207"} + +[Term] +id: MONDO:0002917 +name: disorder of pilosebaceous unit +def: "A disease that involves the pilosebaceous unit." [MONDO:patterns/location] +synonym: "disease of pilosebaceous unit" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pilosebaceous unit" EXACT [] +synonym: "disorder of pilosebaceous unit" EXACT [MONDO:patterns/location_top] +synonym: "hair and hair follicle diseases" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "hair disease" NARROW [MESH:D006201] +synonym: "hair disorder" EXACT [NCIT:C34656] +synonym: "hair/hair follicle diseases" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "pilosebaceous unit disease" EXACT [MONDO:patterns/location] +synonym: "pilosebaceous unit disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:421 {source="MONDO:equivalentTo"} +xref: ICD9:704.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:704.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D006201 {source="MONDO:equivalentTo", source="DOID:421"} +xref: NCIT:C34656 {source="MONDO:equivalentTo", source="DOID:421"} +xref: SCTID:201128002 {source="MONDO:equivalentTo"} +xref: UMLS:C0018500 {source="MONDO:equivalentTo", source="NCIT:C34656", source="DOID:421"} +xref: UMLS:C0554472 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 {source="DOID:421", source="MONDO:Redundant"} ! integumentary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0011932 ! pilosebaceous unit +relationship: disease_has_location UBERON:0011932 ! pilosebaceous unit +property_value: exactMatch DOID:421 +property_value: exactMatch http://identifiers.org/mesh/D006201 +property_value: exactMatch http://identifiers.org/snomedct/201128002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018500 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0554472 +property_value: exactMatch NCIT:C34656 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002919 +name: posterior cranial fossa meningioma +def: "A meningioma that affects the posterior cranial fossa." [NCIT:P378] +synonym: "meningioma (disease) of posterior cranial fossa" EXACT [] +synonym: "meningioma of posterior cranial fossa" EXACT [NCIT:C6775] +synonym: "meningioma of the posterior cranial fossa" EXACT [DOID:4211, NCIT:C6775] +synonym: "posterior cranial fossa meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:4211 {source="MONDO:equivalentTo"} +xref: NCIT:C6775 {source="DOID:4211", source="MONDO:equivalentTo"} +xref: UMLS:C1335448 {source="DOID:4211", source="MONDO:equivalentTo", source="NCIT:C6775"} +is_a: MONDO:0016642 {source="DOID:4211", source="MONDO:Redundant", source="NCIT:C6775/inferred"} ! meningioma +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0008788 ! posterior cranial fossa +relationship: disease_has_location UBERON:0008788 ! posterior cranial fossa +property_value: exactMatch DOID:4211 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335448 +property_value: exactMatch NCIT:C6775 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0002921 +name: congenital structural myopathy +def: "A group of rare genetic muscle disorders characterized by hypotonia, muscle weakness, and delayed development of motor skills." [NCIT:P378] +synonym: "centronuclear myopathy" RELATED [NCIT:C84648] +xref: DOID:422 {source="MONDO:equivalentTo"} +xref: MESH:D020914 {source="MONDO:equivalentTo", source="DOID:422"} +xref: NCIT:C84648 {source="MONDO:equivalentTo", source="DOID:422"} +xref: UMLS:C0752282 {source="NCIT:C84648", source="MONDO:equivalentTo", source="DOID:422"} +is_a: MONDO:0005336 {source="DOID:422", source="NCIT:C84648"} ! myopathy +property_value: exactMatch DOID:422 +property_value: exactMatch http://identifiers.org/mesh/D020914 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0752282 +property_value: exactMatch NCIT:C84648 + +[Term] +id: MONDO:0002924 +name: smooth muscle cancer +def: "A malignant neoplasm arising from smooth muscle." [NCIT:C6511] +synonym: "cancer of smooth muscle" EXACT [NCIT:C6511] +synonym: "cancer of the smooth muscle" EXACT [NCIT:C6511] +synonym: "malignant neoplasm of smooth muscle" EXACT [NCIT:C6511] +synonym: "malignant neoplasm of the smooth muscle" EXACT [NCIT:C6511] +synonym: "malignant smooth muscle neoplasm" EXACT [NCIT:C6511] +synonym: "malignant smooth muscle tumor" EXACT [NCIT:C6511] +synonym: "malignant tumor of smooth muscle" EXACT [DOID:4230, NCIT:C6511] +synonym: "malignant tumor of the smooth muscle" EXACT [NCIT:C6511] +synonym: "smooth muscle cancer" EXACT [NCIT:C6511] +xref: DOID:4230 {source="MONDO:equivalentTo"} +xref: NCIT:C6511 {source="MONDO:equivalentTo", source="DOID:4230"} +xref: UMLS:C1334620 {source="MONDO:equivalentTo", source="NCIT:C6511", source="DOID:4230"} +is_a: MONDO:0005864 {source="DOID:4230", source="MONDO:Redundant", source="NCIT:C6511"} ! muscle cancer +is_a: MONDO:0006975 {source="MONDO:Redundant", source="NCIT:C6511"} ! smooth muscle tumor +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_arises_from_structure CL:0000192 ! smooth muscle cell +property_value: exactMatch DOID:4230 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334620 +property_value: exactMatch NCIT:C6511 + +[Term] +id: MONDO:0002935 +name: penis basal cell carcinoma +def: "A basal cell carcinoma of the penis with an indolent clinical course. It is usually superficial and arises from the shaft and rarely the glans." [NCIT:C39961] +synonym: "basal cell carcinoma of the penis" EXACT [DOID:4277, NCIT:C39961] +synonym: "penile basal cell cancer" EXACT [NCIT:C39961] +synonym: "penile basal cell carcinoma" EXACT [NCIT:C39961] +synonym: "penis skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin basal cell carcinoma of penis" EXACT [MONDO:design_pattern] +synonym: "skin of penis skin basal cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4277 {source="MONDO:equivalentTo"} +xref: NCIT:C39961 {source="DOID:4277", source="MONDO:equivalentTo"} +xref: UMLS:C1518949 {source="DOID:4277", source="NCIT:C39961", source="MONDO:equivalentTo"} +is_a: MONDO:0005341 {source="DOID:4277", source="MONDO:Redundant", source="NCIT:C39961"} ! skin basal cell carcinoma +is_a: MONDO:0018352 ! squamous cell carcinoma of penis +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0000989 ! penis +relationship: disease_has_location UBERON:0001331 ! skin of penis +property_value: exactMatch DOID:4277 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518949 +property_value: exactMatch NCIT:C39961 + +[Term] +id: MONDO:0002936 +name: scrotum basal cell carcinoma +def: "A scrotal carcinoma that involves the basal cell." [MONDO:patterns/location] +synonym: "basal cell carcinoma of scrotum" EXACT [DOID:4278, NCIT:C6386] +synonym: "basal cell carcinoma of the scrotum" RELATED [DOID:4278] +synonym: "basal cell scrotal carcinoma" EXACT [MONDO:patterns/location] +synonym: "scrotal basal cell carcinoma" EXACT [NCIT:C6386] +synonym: "scrotum skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin basal cell carcinoma of scrotum" EXACT [MONDO:design_pattern] +xref: DOID:4278 {source="MONDO:equivalentTo"} +xref: NCIT:C6386 {source="DOID:4278", source="MONDO:equivalentTo"} +xref: UMLS:C1335934 {source="NCIT:C6386", source="DOID:4278", source="MONDO:equivalentTo"} +is_a: MONDO:0001651 ! scrotum squamous cell carcinoma +is_a: MONDO:0005341 {source="MONDO:Redundant", source="NCIT:C6386"} ! skin basal cell carcinoma +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch DOID:4278 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335934 +property_value: exactMatch NCIT:C6386 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002940 +name: anal margin basal cell carcinoma +def: "A basal cell carcinoma arising from the perianal skin. Local excision is the treatment of choice. Metastases are extremely rare." [NCIT:C7473] +synonym: "anal margin basal cell carcinoma" EXACT [NCIT:C7473] +synonym: "basal cell carcinoma of anal margin" EXACT [DOID:4283, NCIT:C7473] +synonym: "basal cell carcinoma of perianal skin" EXACT [DOID:4283, NCIT:C7473] +synonym: "basal cell carcinoma of the anal margin" EXACT [NCIT:C7473] +synonym: "basal cell carcinoma of the perianal skin" EXACT [NCIT:C7473] +synonym: "perianal skin basal cell carcinoma" EXACT [NCIT:C7473] +synonym: "perianal skin skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin basal cell carcinoma of perianal skin" EXACT [MONDO:design_pattern] +xref: DOID:4283 {source="MONDO:equivalentTo"} +xref: NCIT:C7473 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4283"} +xref: UMLS:C1332269 {source="NCIT:C7473", source="MONDO:equivalentTo", source="DOID:4283"} +is_a: MONDO:0001470 ! anal margin squamous cell carcinoma +is_a: MONDO:0005341 {source="DOID:4283", source="MONDO:Redundant", source="NCIT:C7473"} ! skin basal cell carcinoma +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0012336 ! perianal skin +property_value: exactMatch DOID:4283 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332269 +property_value: exactMatch NCIT:C7473 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002941 +name: anal margin carcinoma +def: "A carcinoma that arises from epithelial cells of the perianal skin" [https://orcid.org/0000-0002-6601-2165] +synonym: "anal margin cancer" EXACT [NCIT:C7472] +synonym: "anal margin carcinoma" EXACT [NCIT:C7472] +synonym: "carcinoma of anal margin" EXACT [DOID:4284, NCIT:C7472] +synonym: "carcinoma of perianal skin" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the anal margin" EXACT [NCIT:C7472] +synonym: "perianal skin carcinoma" EXACT [DOID:4284, MONDO:patterns/location, NCIT:C7472] +xref: DOID:4284 {source="MONDO:equivalentTo"} +xref: NCIT:C7472 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4284"} +xref: UMLS:C0349534 {source="NCIT:C7472", source="MONDO:equivalentTo", source="DOID:4284"} +is_a: MONDO:0002656 {source="DOID:4284", source="MONDO:Redundant", source="NCIT:C7472"} ! skin carcinoma +is_a: MONDO:0003199 {source="DOID:4284", source="NCIT:C7472"} ! anal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0012336 ! perianal skin +relationship: disease_has_location UBERON:0012336 ! perianal skin +property_value: exactMatch DOID:4284 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349534 +property_value: exactMatch NCIT:C7472 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002943 +name: external ear basal cell carcinoma +def: "A basal cell carcinoma that arises from the skin of the external ear." [NCIT:C6082] +synonym: "basal cell carcinoma of external Ear" EXACT [NCIT:C6082] +synonym: "basal cell carcinoma of external ear" RELATED [DOID:4287] +synonym: "basal cell carcinoma of the external Ear" EXACT [NCIT:C6082] +synonym: "basal cell carcinoma of the external ear" EXACT [DOID:4287, NCIT:C6082] +synonym: "basal cell external ear carcinoma" EXACT [MONDO:patterns/location] +synonym: "external Ear basal cell carcinoma" EXACT [NCIT:C6082] +synonym: "external ear skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin basal cell carcinoma of external ear" EXACT [MONDO:design_pattern] +xref: DOID:4287 {source="MONDO:equivalentTo"} +xref: NCIT:C6082 {source="DOID:4287", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1333491 {source="DOID:4287", source="MONDO:equivalentTo", source="NCIT:C6082"} +is_a: MONDO:0003501 ! external ear squamous cell carcinoma +is_a: MONDO:0005341 {source="MONDO:Redundant", source="NCIT:C6082"} ! skin basal cell carcinoma +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch DOID:4287 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333491 +property_value: exactMatch NCIT:C6082 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0002944 +name: external ear carcinoma +def: "A carcinoma that arises from epithelial cells of the external ear" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of external Ear" EXACT [NCIT:C6081] +synonym: "carcinoma of external ear" EXACT [DOID:4288, MONDO:patterns/carcinoma] +synonym: "carcinoma of the external Ear" EXACT [NCIT:C6081] +synonym: "carcinoma of the external ear" EXACT [DOID:4288, NCIT:C6081] +synonym: "external Ear carcinoma" EXACT [NCIT:C6081] +synonym: "external ear carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4288 {source="MONDO:equivalentTo"} +xref: NCIT:C6081 {source="DOID:4288", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1333492 {source="DOID:4288", source="MONDO:equivalentTo", source="NCIT:C6081"} +is_a: MONDO:0002038 {source="MONDO:Redundant", source="NCIT:C6081/inferred"} ! head and neck carcinoma +is_a: MONDO:0003574 {source="DOID:4288", source="MONDO:Redundant", source="NCIT:C6081"} ! external ear cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch DOID:4288 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333492 +property_value: exactMatch NCIT:C6081 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0002955 +name: vulva basal cell carcinoma +def: "A slow growing, locally infiltrating carcinoma that arises from the vulva. It is characterized by the presence of malignant cells that resemble the basal cells that are present in the epidermis." [NCIT:C6381] +synonym: "basal cell carcinoma of the vulva" EXACT [DOID:4301, NCIT:C6381] +synonym: "basal cell carcinoma of vulva" EXACT [DOID:4301, NCIT:C6381] +synonym: "mammalian vulva skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin basal cell carcinoma of mammalian vulva" EXACT [MONDO:design_pattern] +synonym: "vulvar basal cell cancer" EXACT [NCIT:C6381] +synonym: "vulvar basal cell carcinoma" EXACT [NCIT:C6381] +xref: DOID:4301 {source="MONDO:equivalentTo"} +xref: NCIT:C6381 {source="DOID:4301", source="MONDO:equivalentTo"} +xref: Orphanet:494451 {source="MONDO:equivalentTo"} +xref: SCTID:717731002 {source="MONDO:equivalentTo"} +xref: UMLS:C1336977 {source="DOID:4301", source="MONDO:equivalentTo", source="NCIT:C6381"} +is_a: MONDO:0005341 {source="DOID:4301", source="MONDO:Redundant", source="NCIT:C6381"} ! skin basal cell carcinoma +is_a: MONDO:0024609 ! vulvar squamous cell carcinoma +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:4301 +property_value: exactMatch http://identifiers.org/snomedct/717731002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336977 +property_value: exactMatch NCIT:C6381 +property_value: exactMatch Orphanet:494451 + +[Term] +id: MONDO:0002969 +name: ciliary body cancer +def: "A malignant neoplasm involving the ciliary body." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of ciliary body" EXACT [MONDO:patterns/cancer] +synonym: "ciliary body cancer" EXACT [MONDO:patterns/location] +synonym: "malignant ciliary body neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4766] +synonym: "malignant ciliary body tumor" EXACT [NCIT:C4766] +synonym: "malignant neoplasm of ciliary body" EXACT [DOID:4352, MONDO:patterns/cancer, NCIT:C4766] +synonym: "malignant neoplasm of the ciliary body" EXACT [NCIT:C4766] +synonym: "malignant tumor of ciliary body" EXACT [NCIT:C4766] +synonym: "malignant tumor of the ciliary body" EXACT [DOID:4352, NCIT:C4766] +synonym: "tumor of the ciliary body" BROAD [DOID:4352, NCIT:C4364] +xref: DOID:4352 {source="MONDO:equivalentTo"} +xref: NCIT:C4766 {source="MONDO:equivalentTo", source="DOID:4352"} +xref: SCTID:188263008 {source="MONDO:equivalentTo", source="DOID:4352"} +xref: UMLS:C0496833 {source="MONDO:equivalentTo", source="NCIT:C4766", source="DOID:4352"} +is_a: MONDO:0002658 {source="DOID:4352", source="MONDO:Entailed", source="MONDO:Redundant"} ! iris cancer +is_a: MONDO:0021229 {source="MONDO:Redundant", source="NCIT:C4766"} ! ciliary body neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001775 ! ciliary body +property_value: exactMatch DOID:4352 +property_value: exactMatch http://identifiers.org/snomedct/188263008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496833 +property_value: exactMatch NCIT:C4766 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0002970 +name: ciliary body disorder +def: "A disease involving the ciliary body." [https://orcid.org/0000-0002-6601-2165] +synonym: "ciliary body disease" EXACT [MONDO:patterns/location, NCIT:C35775] +synonym: "ciliary body disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "ciliary body disorder" EXACT [NCIT:C35775] +synonym: "disease of ciliary body" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ciliary body" EXACT [] +synonym: "disorder of ciliary body" EXACT [MONDO:patterns/location_top] +xref: DOID:4353 {source="MONDO:equivalentTo"} +xref: NCIT:C35775 {source="DOID:4353", source="MONDO:equivalentTo"} +xref: SCTID:68575007 {source="DOID:4353", source="MONDO:equivalentTo"} +xref: UMLS:C0271100 {source="DOID:4353", source="MONDO:equivalentTo", source="NCIT:C35775"} +is_a: MONDO:0002289 {source="DOID:4353"} ! iris disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001775 ! ciliary body +relationship: disease_has_location UBERON:0001775 ! ciliary body +property_value: exactMatch DOID:4353 +property_value: exactMatch http://identifiers.org/snomedct/68575007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271100 +property_value: exactMatch NCIT:C35775 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0002974 +name: cervical cancer +def: "A primary or metastatic malignant neoplasm involving the cervix." [NCIT:C9311] +synonym: "cancer of uterine cervix" EXACT [MONDO:patterns/cancer] +synonym: "cervical cancer, somatic" EXACT [OMIM:603956, OMIM:genemap2] +synonym: "cervical neoplasm" BROAD [DOID:4362] +synonym: "cervix cancer" EXACT [DOID:4362] +synonym: "cervix uteri cancer" EXACT [DOID:4362] +synonym: "malignant cervical neoplasm" EXACT [NCIT:C9311] +synonym: "malignant cervical tumor" EXACT [NCIT:C9311] +synonym: "malignant cervix neoplasm" EXACT [NCIT:C9311] +synonym: "malignant cervix tumor" EXACT [NCIT:C9311] +synonym: "malignant cervix uteri neoplasm" EXACT [NCIT:C9311] +synonym: "malignant cervix uteri tumor" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of cervix" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of cervix uteri" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of the cervix" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of the cervix uteri" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of the uterine cervix" EXACT [NCIT:C9311] +synonym: "malignant neoplasm of uterine cervix" EXACT [MONDO:patterns/cancer, NCIT:C9311] +synonym: "malignant tumor of cervix" EXACT [NCIT:C9311] +synonym: "malignant tumor of cervix uteri" EXACT [NCIT:C9311] +synonym: "malignant tumor of the cervix" EXACT [NCIT:C9311] +synonym: "malignant tumor of the cervix uteri" EXACT [NCIT:C9311] +synonym: "malignant tumor of the uterine cervix" EXACT [NCIT:C9311] +synonym: "malignant tumor of uterine cervix" EXACT [NCIT:C9311] +synonym: "malignant uterine cervix neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9311] +synonym: "malignant uterine cervix tumor" EXACT [NCIT:C9311] +synonym: "tumor of the cervix uteri" BROAD [DOID:4362, NCIT:C2940] +synonym: "uterine cervical neoplasm" BROAD [DOID:4362] +synonym: "uterine cervix cancer" EXACT [MONDO:patterns/location] +xref: DOID:4362 {source="MONDO:equivalentTo"} +xref: ICD9:180 {source="DOID:4362"} +xref: ICD9:180.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:180.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:4362"} +xref: NCIT:C9311 {source="MONDO:equivalentTo", source="DOID:4362"} +xref: OMIM:603956 {source="MONDO:equivalentTo", source="DOID:4362"} +xref: SCTID:363354003 {source="MONDO:equivalentTo", source="DOID:4362"} +is_a: MONDO:0002715 {source="MONDO:Redundant", source="NCIT:C9311"} ! uterine cancer +is_a: MONDO:0021230 {source="MONDO:Redundant", source="NCIT:C9311"} ! uterine cervix neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +property_value: exactMatch DOID:4362 +property_value: exactMatch http://identifiers.org/snomedct/363354003 +property_value: exactMatch https://omim.org/entry/603956 +property_value: exactMatch NCIT:C9311 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0002977 +name: autoimmune disorder of the nervous system +def: "A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis." [NCIT:C99383] +synonym: "autoimmune disease of nervous system" EXACT [MONDO:design_pattern] +synonym: "autoimmune disease, neurologic" EXACT [MESH:D020274] +synonym: "autoimmune diseases, nervous system" EXACT [MESH:D020274] +synonym: "autoimmune diseases, neurologic" EXACT [MESH:D020274] +synonym: "autoimmune disorders of the nervous system" EXACT [MESH:D020274] +synonym: "autoimmune disorders, nervous system" EXACT [MESH:D020274] +synonym: "autoimmune nervous system diseases" EXACT [MESH:D020274] +synonym: "autoimmune nervous system disorder" EXACT [DOID:438, NCIT:C99383] +synonym: "disease, neurologic autoimmune" EXACT [MESH:D020274] +synonym: "diseases, neurologic autoimmune" EXACT [MESH:D020274] +synonym: "immune diseases, nervous system" EXACT [MESH:D020274] +synonym: "immune disorders, nervous system" EXACT [MESH:D020274] +synonym: "nervous system autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "nervous system autoimmune diseases" EXACT [MESH:D020274] +synonym: "nervous system hypersensitivity reaction type II disease" EXACT [MONDO:patterns/location] +synonym: "nervous system immune diseases" EXACT [MESH:D020274] +synonym: "nervous system immune disorders" EXACT [MESH:D020274] +synonym: "neurologic autoimmune disease" EXACT [MESH:D020274] +synonym: "neurologic autoimmune diseases" EXACT [MESH:D020274] +xref: DOID:438 {source="MONDO:equivalentTo"} +xref: MESH:D020274 {source="DOID:438", source="MONDO:equivalentTo"} +xref: NCIT:C99383 {source="DOID:438", source="MONDO:equivalentTo"} +xref: UMLS:C0751871 {source="DOID:438", source="NCIT:C99383", source="MONDO:equivalentTo"} +xref: UMLS:C0751872 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 {source="MESH:D020274", source="MONDO:Redundant", source="NCIT:C99383/inferred"} ! nervous system disorder +is_a: MONDO:0007179 {source="DOID:438", source="MESH:D020274", source="MONDO:Redundant", source="NCIT:C99383"} ! autoimmune disease +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0001016 ! nervous system +property_value: exactMatch DOID:438 +property_value: exactMatch http://identifiers.org/mesh/D020274 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751871 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751872 +property_value: exactMatch NCIT:C99383 + +[Term] +id: MONDO:0002994 +name: pancreatic delta cell neuroendocrine tumor +def: "A usually malignant neuroendocrine tumor arising from the delta cells of the pancreas. It may be associated with inappropriate secretion of somatostatin and an associated clinical syndrome, or it may be hormonally inactive (non-functioning)." [NCIT:C28396] +synonym: "pancreatic Delta cell neoplasm" EXACT [NCIT:C28396] +synonym: "pancreatic delta cell neoplasm" EXACT [DOID:4433] +synonym: "pancreatic Delta cell NET" EXACT [NCIT:C28396] +synonym: "pancreatic Delta cell neuroendocrine tumor" EXACT [NCIT:C28396] +synonym: "pancreatic Delta cell tumor" EXACT [DOID:4433, NCIT:C28396] +xref: DOID:4433 {source="MONDO:equivalentTo"} +xref: NCIT:C28396 {source="DOID:4433", source="MONDO:equivalentTo"} +xref: UMLS:C1335301 {source="NCIT:C28396", source="DOID:4433", source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="MONDO:Redundant", source="NCIT:C28396/inferred"} ! epithelial neoplasm +is_a: MONDO:0019954 {source="MONDO:Redundant", source="NCIT:C28396"} ! pancreatic neuroendocrine tumor +intersection_of: MONDO:0019954 {source="NCIT:C28396"} ! pancreatic neuroendocrine tumor +intersection_of: disease_arises_from_structure CL:0000173 {source="NCIT:C28396"} ! pancreatic D cell +relationship: disease_arises_from_structure CL:0000173 ! pancreatic D cell +property_value: exactMatch DOID:4433 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335301 +property_value: exactMatch NCIT:C28396 + +[Term] +id: MONDO:0002995 +name: small intestine neuroendocrine tumor, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the small intestine." [NCIT:C96061] +synonym: "carcinoid tumor of small intestine" RELATED [MONDO:cjm] +synonym: "small intestinal NET" BROAD [NCIT:C96061] +synonym: "small intestinal neuroendocrine tumor" BROAD [NCIT:C96061] +synonym: "small intestinal well differentiated endocrine tumor" BROAD [NCIT:C96061] +synonym: "small intestinal well differentiated endocrine tumor/carcinoma" NARROW [NCIT:C96061] +synonym: "small intestine neuroendocrine tumor" BROAD [MONDO:patterns/location, NCIT:C5803] +xref: EFO:1001928 {source="MONDO:equivalentTo"} +xref: NCIT:C96061 {source="MONDO:equivalentTo"} +xref: UMLS:C3272528 {source="NCIT:C96061", source="MONDO:equivalentTo"} +is_a: MONDO:0000386 ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0018510 {source="MONDO:Redundant", source="NCIT:C96061"} ! small intestine neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002108 ! small intestine +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3272528 +property_value: exactMatch NCIT:C96061 + +[Term] +id: MONDO:0002997 +name: anterior cranial fossa meningioma +def: "A meningioma that affects the anterior cranial fossa." [NCIT:P378] +synonym: "anterior cranial fossa meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "anterior fossa meningioma" EXACT [NCIT:C5286] +synonym: "meningioma (disease) of anterior cranial fossa" EXACT [] +synonym: "meningioma of anterior cranial fossa" EXACT [NCIT:C5286] +synonym: "meningioma of anterior fossa" EXACT [NCIT:C5286] +synonym: "meningioma of the anterior cranial fossa" EXACT [NCIT:C5286] +synonym: "meningioma of the anterior fossa" EXACT [DOID:4436, NCIT:C5286] +xref: DOID:4436 {source="MONDO:equivalentTo"} +xref: NCIT:C5286 {source="MONDO:equivalentTo", source="DOID:4436"} +xref: UMLS:C1332301 {source="NCIT:C5286", source="MONDO:equivalentTo", source="DOID:4436"} +is_a: MONDO:0016642 {source="DOID:4436", source="MONDO:Redundant", source="NCIT:C5286/inferred"} ! meningioma +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0003720 ! anterior cranial fossa +relationship: disease_has_location UBERON:0003720 ! anterior cranial fossa +property_value: exactMatch DOID:4436 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332301 +property_value: exactMatch NCIT:C5286 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0002998 +name: skull base meningioma +def: "A meningioma that arises from the skull base." [NCIT:C5272] +synonym: "basicranium meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of basicranium" EXACT [] +synonym: "meningioma of skull base" RELATED [NCIT:C5272] +synonym: "meningioma of the skull base" EXACT [DOID:4437, NCIT:C5272] +synonym: "skull base meningioma" EXACT [NCIT:C5272] +xref: DOID:4437 {source="MONDO:equivalentTo"} +xref: NCIT:C5272 {source="DOID:4437", source="MONDO:equivalentTo"} +xref: UMLS:C1335976 {source="NCIT:C5272", source="DOID:4437", source="MONDO:equivalentTo"} +is_a: MONDO:0002785 {source="DOID:4437", source="MONDO:Redundant", source="NCIT:C5272"} ! skull base neoplasm +is_a: MONDO:0016642 {source="MONDO:Redundant", source="NCIT:C5272/inferred"} ! meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0002517 ! basicranium +property_value: exactMatch DOID:4437 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335976 +property_value: exactMatch NCIT:C5272 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003000 +name: central nervous system germ cell tumor +def: "A unique group of rare tumors of the central nervous system that affect mainly children and adolescents. Their morphologic and biologic profile corresponds to that of homologous germ cell tumors that arise in the gonads and in other extragonadal sites. Representative examples include: germinoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma." [NCIT:C5461] +synonym: "central nervous system germ cell neoplasm" EXACT [NCIT:C5461] +synonym: "central nervous system germ cell tumor" EXACT [MONDO:patterns/location, NCIT:C5461] +synonym: "central nervous system rare germ cell tumor" EXACT [MONDO:patterns/location] +synonym: "CNS germ cell neoplasm" EXACT [NCIT:C5461] +synonym: "CNS germ cell tumor" EXACT [NCIT:C5461] +synonym: "germ cell neoplasm of central nervous system" EXACT [NCIT:C5461] +synonym: "germ cell neoplasm of CNS" EXACT [NCIT:C5461] +synonym: "germ cell neoplasm of the central nervous system" EXACT [NCIT:C5461] +synonym: "germ cell neoplasm of the CNS" EXACT [NCIT:C5461] +synonym: "germ cell tumor of central nervous system" EXACT [NCIT:C5461] +synonym: "germ cell tumor of CNS" EXACT [NCIT:C5461] +synonym: "germ cell tumor of the central nervous system" EXACT [NCIT:C5461] +synonym: "germ cell tumor of the CNS" EXACT [DOID:4439, NCIT:C5461] +xref: DOID:4439 {source="MONDO:equivalentTo"} +xref: NCIT:C5461 {source="MONDO:equivalentTo", source="DOID:4439"} +xref: UMLS:C1332880 {source="NCIT:C5461", source="MONDO:equivalentTo", source="DOID:4439"} +is_a: MONDO:0006130 {source="MONDO:Redundant", source="NCIT:C5461"} ! central nervous system neoplasm +is_a: MONDO:0018201 {source="NCIT:C5461"} ! extragonadal germ cell tumor +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:4439 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332880 +property_value: exactMatch NCIT:C5461 + +[Term] +id: MONDO:0003007 +name: childhood kidney cell carcinoma +def: "A renal cell carcinoma that occurs during childhood." [NCIT:P378] +synonym: "childhood kidney cell carcinoma" EXACT [NCIT:C6568] +synonym: "childhood renal cell carcinoma" EXACT [NCIT:C6568] +synonym: "childhood renal cell carcinoma (disease)" EXACT [] +synonym: "pediatric kidney cell carcinoma" EXACT [NCIT:C6568] +synonym: "pediatric renal cell carcinoma" EXACT [DOID:4454, NCIT:C6568] +synonym: "pediatric renal cell carcinoma (disease)" EXACT [MONDO:patterns/childhood] +synonym: "renal cell cancer" BROAD [NCIT:C6568] +synonym: "renal cell carcinoma (disease) of childhood" EXACT [MONDO:patterns/childhood] +xref: DOID:4454 {source="MONDO:equivalentTo"} +xref: NCIT:C6568 {source="DOID:4454", source="MONDO:equivalentTo"} +xref: UMLS:C1333001 {source="DOID:4454", source="MONDO:equivalentTo", source="NCIT:C6568"} +is_a: MONDO:0005549 {source="NCIT:C6568"} ! renal cell adenocarcinoma +is_a: MONDO:0036511 ! childhood malignant kidney neoplasm +intersection_of: MONDO:0005086 ! renal cell carcinoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:4454 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333001 +property_value: exactMatch NCIT:C6568 + +[Term] +id: MONDO:0003008 +name: hereditary renal cell carcinoma +def: "An instance of renal cell carcinoma (disease) that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: gard_rare {source="GARD:0009571"} +synonym: "familial renal carcinoma" RELATED [MESH:C536851] +synonym: "hereditary renal carcinoma" RELATED [] +synonym: "hereditary renal cell cancer" EXACT [NCIT:C39789] +synonym: "hereditary renal cell carcinoma" EXACT [NCIT:C39789] +synonym: "hereditary renal cell carcinoma (disease)" EXACT [MONDO:patterns/hereditary] +xref: DOID:4455 {source="MONDO:equivalentTo"} +xref: GARD:0009571 {source="MONDO:equivalentTo"} +xref: MESH:C536851 {source="MONDO:equivalentTo"} +xref: NCIT:C39789 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:717736007 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005549 {source="NCIT:C39789"} ! renal cell adenocarcinoma +intersection_of: MONDO:0005086 ! renal cell carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:4455 +property_value: exactMatch http://identifiers.org/mesh/C536851 +property_value: exactMatch http://identifiers.org/snomedct/717736007 +property_value: exactMatch NCIT:C39789 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9571/hereditary-renal-cell-carcinoma xsd:anyURI {source="GARD:0009571"} + +[Term] +id: MONDO:0003014 +name: rhinitis +def: "An inflammation of the mucous membrane lining the nose, usually associated with nasal discharge." [NCIT:C34986] +synonym: "inflammation of nasal cavity mucosa" EXACT [] +synonym: "nasal cavity mucosa inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "runny nose" RELATED [DOID:4483] +xref: DOID:4483 {source="MONDO:equivalentTo"} +xref: EFO:0008521 {source="MONDO:equivalentTo"} +xref: ICD10CM:J30 {source="MONDO:equivalentTo"} +xref: MESH:D012220 {source="MONDO:equivalentTo", source="DOID:4483"} +xref: NCIT:C34986 {source="MONDO:equivalentTo", source="DOID:4483"} +xref: SCTID:70076002 {source="MONDO:equivalentTo", source="DOID:4483"} +xref: UMLS:C0035455 {source="MONDO:equivalentTo", source="NCIT:C34986", source="DOID:4483"} +is_a: MONDO:0002232 {source="DOID:4483", source="NCIT:C34986/inferred"} ! nasal cavity disorder +is_a: MONDO:0020579 ! mucositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001826 ! nasal cavity mucosa +relationship: disease_has_feature HP:0002315 {source="MONDO:Wikidata"} ! Headache +relationship: disease_has_inflammation_site UBERON:0001826 ! nasal cavity mucosa +property_value: exactMatch DOID:4483 +property_value: exactMatch http://identifiers.org/mesh/D012220 +property_value: exactMatch http://identifiers.org/snomedct/70076002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035455 +property_value: exactMatch https://icd.codes/icd10cm/J30 +property_value: exactMatch NCIT:C34986 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003045 +name: anal gland neoplasm +def: "Tumors or cancer of the anal gland." [MESH:D000694] +synonym: "gland of anal canal neoplasm" EXACT [] +synonym: "gland of anal canal neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "gland of anal canal tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of gland of anal canal" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of gland of anal canal" EXACT [MONDO:patterns/neoplasm] +xref: DOID:4550 {source="MONDO:equivalentTo"} +xref: EFO:1000804 {source="MONDO:equivalentTo"} +xref: MESH:D000694 {source="MONDO:equivalentTo", source="DOID:4550"} +xref: UMLS:C0002757 {source="MONDO:equivalentTo", source="DOID:4550"} +is_a: MONDO:0003046 {source="DOID:4550", source="EFO:1000804", source="MESH:D000694"} ! anus neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0004760 ! gland of anal canal +relationship: disease_has_location UBERON:0004760 ! gland of anal canal +property_value: exactMatch DOID:4550 +property_value: exactMatch http://identifiers.org/mesh/D000694 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0002757 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003046 +name: anus neoplasm +def: "A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma." [NCIT:P378] +synonym: "anal neoplasm" EXACT [DOID:4551, NCIT:C2877] +synonym: "anal neoplasms, benign and malignant" EXACT [NCIT:C2877] +synonym: "anal tumor" EXACT [NCIT:C2877] +synonym: "anal tumors" EXACT [DOID:4551, NCIT:C2877] +synonym: "anus neoplasm" EXACT [NCIT:C2877] +synonym: "anus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "anus tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of anus" EXACT [DOID:4551, MONDO:patterns/neoplasm, NCIT:C2877] +synonym: "neoplasm of the anus" EXACT [NCIT:C2877] +synonym: "tumor of anus" EXACT [MONDO:patterns/neoplasm, NCIT:C2877] +synonym: "tumor of the anus" EXACT [NCIT:C2877] +xref: DOID:4551 {source="MONDO:equivalentTo"} +xref: EFO:0003835 {source="MONDO:equivalentTo"} +xref: MESH:D001005 {source="DOID:4551", source="MONDO:equivalentTo"} +xref: NCIT:C2877 {source="DOID:4551", source="MONDO:equivalentTo"} +xref: SCTID:126849006 {source="DOID:4551", source="MONDO:equivalentTo"} +xref: UMLS:C0003463 {source="DOID:4551", source="MONDO:equivalentTo", source="NCIT:C2877"} +is_a: MONDO:0002165 {source="MESH:D001005", source="MONDO:Redundant"} ! rectal neoplasm +is_a: MONDO:0002519 {source="MESH:D001005", source="MONDO:Redundant", source="NCIT:C2877"} ! anus disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:4551 +property_value: exactMatch http://identifiers.org/mesh/D001005 +property_value: exactMatch http://identifiers.org/snomedct/126849006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003463 +property_value: exactMatch NCIT:C2877 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003053 +name: choroid plexus meningioma +def: "A meningioma that affects the choroid plexus." [NCIT:P378] +synonym: "choroid meningioma (morphologic abnormality)" EXACT [DOID:4584] +synonym: "choroid plexus meningioma" EXACT [NCIT:C4719] +synonym: "choroid plexus meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of choroid plexus" EXACT [] +synonym: "meningioma of choroid plexus" RELATED [NCIT:C4719] +synonym: "meningioma of the choroid plexus" EXACT [DOID:4584, NCIT:C4719] +xref: DOID:4584 {source="MONDO:equivalentTo"} +xref: NCIT:C4719 {source="DOID:4584", source="MONDO:equivalentTo"} +xref: UMLS:C0431118 {source="DOID:4584", source="NCIT:C4719", source="MONDO:equivalentTo"} +is_a: MONDO:0002681 ! choroid plexus cancer +is_a: MONDO:0002772 ! intraventricular meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0001886 ! choroid plexus +property_value: exactMatch DOID:4584 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0431118 +property_value: exactMatch NCIT:C4719 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003054 +name: benign meningioma +def: "A grade I, slowly growing meningioma. Only a minority of tumors recur following complete resection." [NCIT:C4055] +synonym: "benign meningioma (WHO grade I)" EXACT [NCIT:C4055] +synonym: "meningioma (disease), benign" EXACT [MONDO:patterns/benign] +synonym: "meningioma, benign" EXACT [DOID:4587, NCIT:C4055] +xref: DOID:4587 {source="MONDO:equivalentTo"} +xref: NCIT:C4055 {source="DOID:4587", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:724171006 {source="MONDO:equivalentTo"} +xref: UMLS:C0281784 {source="DOID:4587", source="NCIT:C4055", source="MONDO:equivalentTo"} +is_a: MONDO:0016642 {source="MONDO:Redundant", source="NCIT:C4055/inferred"} ! meningioma +is_a: MONDO:0021527 {source="MONDO:Redundant", source="NCIT:C4055"} ! benign neoplasm of meninges +intersection_of: MONDO:0016642 ! meningioma +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:4587 +property_value: exactMatch http://identifiers.org/snomedct/724171006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0281784 +property_value: exactMatch NCIT:C4055 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0003057 +name: pediatric meningioma +def: "A meningioma that occurs during childhood." [NCIT:P378] +synonym: "childhood meningioma" EXACT [NCIT:C8264] +synonym: "childhood meningioma (disease)" EXACT [] +synonym: "meningioma" BROAD [NCIT:C8264] +synonym: "meningioma (disease) of childhood" EXACT [MONDO:patterns/childhood] +synonym: "pediatric meningioma" EXACT [NCIT:C8264] +synonym: "pediatric meningioma (disease)" EXACT [MONDO:patterns/childhood] +xref: DOID:4593 {source="MONDO:equivalentTo"} +xref: NCIT:C8264 {source="MONDO:equivalentTo", source="DOID:4593"} +xref: UMLS:C0280656 {source="NCIT:C8264", source="MONDO:equivalentTo", source="DOID:4593"} +is_a: MONDO:0016642 {source="DOID:4593", source="MONDO:Redundant", source="NCIT:C8264"} ! meningioma +is_a: MONDO:0021079 ! childhood neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:4593 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280656 +property_value: exactMatch NCIT:C8264 + +[Term] +id: MONDO:0003059 +name: bile duct cancer +def: "A malignant neoplasm involving the bile duct" [https://orcid.org/0000-0002-6601-2165] +synonym: "bile duct cancer" EXACT [MONDO:patterns/location] +synonym: "bile duct tumor" BROAD [DOID:4606, NCIT:C2898] +synonym: "Ca extrahepatic bile ducts" EXACT [DOID:4606] +synonym: "cancer of bile duct" EXACT [MONDO:patterns/cancer] +synonym: "malignant bile duct neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of bile duct" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the extrahepatic bile duct" NARROW [DOID:4606, NCIT:C7483] +xref: DOID:4606 {source="MONDO:equivalentTo"} +xref: ICD9:156.1 {source="MONDO:relatedTo", source="DOID:4606"} +xref: NCIT:C2898 {source="DOID:4606", source="MONDO:directSiblingOf"} +xref: UMLS:C0005396 {source="DOID:4606", source="MONDO:directSiblingOf"} +is_a: MONDO:0003060 {source="DOID:4606", source="MONDO:Entailed", source="MONDO:Redundant"} ! biliary tract cancer +is_a: MONDO:0021662 ! bile duct neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch DOID:4606 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003060 +name: biliary tract cancer +def: "A malignant neoplasm involving the biliary tree" [https://orcid.org/0000-0002-6601-2165] +subset: gard_rare {source="GARD:0005924"} +synonym: "biliary tree cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of biliary tree" EXACT [MONDO:patterns/cancer] +synonym: "malignant biliary tree neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of biliary tree" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumour of biliary tract" EXACT [DOID:4607] +xref: DOID:4607 {source="MONDO:equivalentTo"} +xref: GARD:0005924 {source="MONDO:equivalentTo"} +xref: ICD9:156.9 {source="DOID:4607"} +is_a: MONDO:0002691 ! liver cancer +is_a: MONDO:0005304 ! biliary tract neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001173 ! biliary tree +property_value: exactMatch DOID:4607 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5924/biliary-tract-cancer xsd:anyURI {source="GARD:0005924"} + +[Term] +id: MONDO:0003061 +name: benign muscle neoplasm +alt_id: MONDO:0002393 +def: "A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue." [NCIT:C4882] +synonym: "benign muscle neoplasm" EXACT [NCIT:C4882] +synonym: "benign muscle tumor" EXACT [NCIT:C4882] +synonym: "benign neoplasm of muscle" EXACT [NCIT:C4882] +synonym: "benign neoplasm of the muscle" EXACT [NCIT:C4882] +synonym: "benign tumor of muscle" EXACT [NCIT:C4882] +synonym: "benign tumor of the muscle" EXACT [NCIT:C4882] +synonym: "muscle benign neoplasm" RELATED [DOID:461] +synonym: "muscle neoplasm" BROAD [DOID:461] +synonym: "muscle tissue neoplasm" EXACT [DOID:461] +synonym: "myoma" EXACT [NCIT:C4882] +synonym: "myomatous tumor" BROAD [DOID:461, NCIT:C4063] +xref: DOID:2691 {source="MONDO:equivalentTo"} +xref: DOID:461 {source="MONDO:equivalentTo"} +xref: ICDO:8895/0 {source="NCIT:C4882"} +xref: MESH:D009214 {source="MONDO:equivalentTo", source="DOID:2691"} +xref: NCIT:C4882 {source="MONDO:equivalentTo", source="DOID:2691"} +is_a: MONDO:0000636 {source="DOID:2691/inferred", source="DOID:461"} ! musculoskeletal system benign neoplasm +is_a: MONDO:0021545 {source="MESH:D009214", source="MONDO:Redundant", source="NCIT:C4882"} ! myomatous neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_arises_from_structure CL:0000187 ! muscle cell +property_value: exactMatch DOID:2691 +property_value: exactMatch DOID:461 +property_value: exactMatch http://identifiers.org/mesh/D009214 +property_value: exactMatch NCIT:C4882 + +[Term] +id: MONDO:0003062 +name: intestinal benign neoplasm +def: "A benign neoplasm that involves the intestine." [MONDO:patterns/location] +synonym: "benign intestinal neoplasm" EXACT [NCIT:C4609] +synonym: "benign intestinal neoplasms" EXACT [NCIT:C4609] +synonym: "benign intestinal tumor" EXACT [NCIT:C4609] +synonym: "benign intestinal tumors" EXACT [NCIT:C4609] +synonym: "benign intestine neoplasm" EXACT [NCIT:C4609] +synonym: "benign intestine tumor" EXACT [NCIT:C4609] +synonym: "benign neoplasm of intestines" EXACT [NCIT:C4609] +synonym: "benign neoplasm of the intestines" EXACT [NCIT:C4609] +synonym: "benign neoplasms of large and/or small intestine" EXACT [NCIT:C4609] +synonym: "benign neoplasms of the large and/or small intestine" EXACT [NCIT:C4609] +synonym: "benign tumor of intestines" EXACT [NCIT:C4609] +synonym: "benign tumor of the intestines" EXACT [NCIT:C4609] +synonym: "intestinal neoplasms, benign" EXACT [NCIT:C4609] +synonym: "intestinal tumors, benign" EXACT [NCIT:C4609] +synonym: "intestine benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4609 {source="MONDO:equivalentTo"} +xref: SCTID:92151003 {source="MONDO:equivalentTo"} +xref: UMLS:C0347269 {source="NCIT:C4609", source="MONDO:equivalentTo"} +is_a: MONDO:0000385 {source="DOID:4610", source="MONDO:Redundant", source="NCIT:C4609"} ! benign digestive system neoplasm +is_a: MONDO:0021118 {source="MONDO:Redundant", source="NCIT:C4609"} ! intestinal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000160 ! intestine +property_value: exactMatch http://identifiers.org/snomedct/92151003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347269 +property_value: exactMatch NCIT:C4609 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0003066 +name: submandibular adenitis +def: "Inflammation of the submandibular lymph nodes." [NCIT:P378] +synonym: "lymphadenitis (disease) of submandibular gland" EXACT [] +synonym: "submandibular gland lymphadenitis (disease)" EXACT [MONDO:patterns/location] +synonym: "submandibular lymphadenitis" EXACT [DOID:4636, NCIT:C27016] +xref: DOID:4636 {source="MONDO:equivalentTo"} +xref: NCIT:C27016 {source="MONDO:equivalentTo", source="DOID:4636"} +xref: SCTID:15170009 {source="MONDO:equivalentTo", source="DOID:4636"} +xref: UMLS:C0235591 {source="MONDO:equivalentTo", source="NCIT:C27016", source="DOID:4636"} +is_a: MONDO:0001597 ! submandibular gland disorder +is_a: MONDO:0003067 {source="DOID:4636"} ! cervical lymphadenitis +is_a: MONDO:0006969 ! sialadenitis +intersection_of: MONDO:0002052 ! lymphadenitis +intersection_of: disease_has_location UBERON:0001736 ! submandibular gland +property_value: exactMatch DOID:4636 +property_value: exactMatch http://identifiers.org/snomedct/15170009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235591 +property_value: exactMatch NCIT:C27016 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003067 +name: cervical lymphadenitis +def: "Inflammation of the cervical lymph nodes." [NCIT:P378] +synonym: "cervical adenitis" EXACT [DOID:4637] +synonym: "lymphadenitis (disease) of neck" EXACT [] +synonym: "neck lymphadenitis (disease)" EXACT [MONDO:patterns/location] +xref: DOID:4637 {source="MONDO:equivalentTo"} +xref: NCIT:C26937 {source="MONDO:equivalentTo", source="DOID:4637"} +xref: SCTID:3502005 {source="MONDO:equivalentTo", source="DOID:4637"} +xref: UMLS:C0149642 {source="MONDO:equivalentTo", source="DOID:4637", source="NCIT:C26937"} +is_a: MONDO:0002052 {source="DOID:4637", source="MONDO:Redundant", source="NCIT:C26937"} ! lymphadenitis +intersection_of: MONDO:0002052 ! lymphadenitis +intersection_of: disease_has_location UBERON:0000974 ! neck +relationship: disease_has_location UBERON:0000974 ! neck +property_value: exactMatch DOID:4637 +property_value: exactMatch http://identifiers.org/snomedct/3502005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149642 +property_value: exactMatch NCIT:C26937 + +[Term] +id: MONDO:0003070 +name: axillary lymphadenitis +def: "An infection of the lymph nodes in the axilla." [NCIT:C27333] +synonym: "axilla lymphadenitis (disease)" EXACT [MONDO:patterns/location] +synonym: "axillary adenitis" RELATED [NCIT:C27333] +synonym: "axillary lymphadenitis" EXACT [NCIT:C27333] +synonym: "lymphadenitis (disease) of axilla" EXACT [] +xref: DOID:4640 {source="MONDO:equivalentTo"} +xref: NCIT:C27333 {source="DOID:4640", source="NCIT:C27333", source="MONDO:equivalentTo"} +xref: UMLS:C0919797 {source="DOID:4640", source="NCIT:C27333", source="MONDO:equivalentTo"} +is_a: MONDO:0002052 {source="DOID:4640", source="MONDO:Redundant", source="NCIT:C27333"} ! lymphadenitis +intersection_of: MONDO:0002052 ! lymphadenitis +intersection_of: disease_has_location UBERON:0009472 ! axilla +relationship: disease_has_location UBERON:0009472 ! axilla +property_value: exactMatch DOID:4640 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0919797 +property_value: exactMatch NCIT:C27333 + +[Term] +id: MONDO:0003072 +name: retinal cancer +def: "A malignant neoplasm involving the retina." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of retina" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of retina" EXACT [DOID:4645, MONDO:patterns/cancer, NCIT:C3216] +synonym: "malignant neoplasm of the retina" EXACT [NCIT:C3216] +synonym: "malignant retina neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3216] +synonym: "malignant retina tumor" EXACT [NCIT:C3216] +synonym: "malignant retinal neoplasm" EXACT [DOID:4645, NCIT:C3216] +synonym: "malignant retinal tumor" EXACT [NCIT:C3216] +synonym: "malignant tumor of retina" EXACT [NCIT:C3216] +synonym: "malignant tumor of the retina" EXACT [NCIT:C3216] +synonym: "retina cancer" EXACT [MONDO:patterns/location] +synonym: "retinal tumor" BROAD [DOID:4645, NCIT:C4800] +xref: DOID:4645 {source="MONDO:equivalentTo"} +xref: EFO:0005716 {source="MONDO:equivalentTo"} +xref: ICD9:190.5 {source="MONDO:equivalentTo", source="DOID:4645", source="MONDO:i2s"} +xref: MESH:D019572 {source="MONDO:equivalentTo", source="DOID:4645"} +xref: NCIT:C3216 {source="MONDO:equivalentTo", source="DOID:4645"} +xref: SCTID:363465007 {source="MONDO:equivalentTo", source="DOID:4645"} +is_a: MONDO:0002236 {source="DOID:4645", source="MESH:D019572", source="MONDO:Redundant", source="NCIT:C3216"} ! ocular cancer +is_a: MONDO:0021231 {source="MONDO:Redundant", source="NCIT:C3216"} ! retina neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch DOID:4645 +property_value: exactMatch http://identifiers.org/mesh/D019572 +property_value: exactMatch http://identifiers.org/snomedct/363465007 +property_value: exactMatch NCIT:C3216 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003081 +name: thalamic disorder +def: "A disorder of the thalamus. Causes include brain neoplasms, cerebrovascular disorders, brain trauma, brain hypoxia, infections, and brain hemorrhage. Signs and symptoms include movement and sensory abnormalities, visual abnormalities, ataxia, and coma." [NCIT:P378] +synonym: "disease of dorsal plus ventral thalamus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of dorsal plus ventral thalamus" EXACT [] +synonym: "disorder of dorsal plus ventral thalamus" EXACT [MONDO:patterns/location_top] +synonym: "dorsal plus ventral thalamus disease" EXACT [MONDO:patterns/location] +synonym: "dorsal plus ventral thalamus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:4662 {source="MONDO:equivalentTo"} +xref: MESH:D013786 {source="DOID:4662", source="MONDO:equivalentTo"} +xref: NCIT:C85186 {source="DOID:4662", source="MONDO:equivalentTo"} +xref: UMLS:C0039726 {source="DOID:4662", source="MONDO:equivalentTo", source="NCIT:C85186"} +is_a: MONDO:0005560 {source="DOID:4662", source="MESH:D013786", source="MONDO:Entailed", source="MONDO:Redundant"} ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001897 ! dorsal plus ventral thalamus +relationship: disease_has_location UBERON:0001897 ! dorsal plus ventral thalamus +property_value: exactMatch DOID:4662 +property_value: exactMatch http://identifiers.org/mesh/D013786 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039726 +property_value: exactMatch NCIT:C85186 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003085 +name: keratitis +def: "A corneal disease that is characterized by inflammation of the cornea." [NCIT:C26805] +synonym: "cornea inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of cornea" EXACT [] +xref: DOID:4677 {source="MONDO:equivalentTo"} +xref: ICD10CM:H16 {source="DOID:4677", source="MONDO:equivalentTo"} +xref: ICD9:370 {source="DOID:4677"} +xref: ICD9:370.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:370.9 {source="DOID:4677", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D007634 {source="DOID:4677", source="MONDO:equivalentTo"} +xref: NCIT:C26805 {source="DOID:4677", source="MONDO:equivalentTo"} +xref: SCTID:5888003 {source="DOID:4677", source="MONDO:equivalentTo"} +xref: UMLS:C0022568 {source="DOID:4677", source="MONDO:equivalentTo", source="NCIT:C26805"} +is_a: MONDO:0000942 {source="DOID:4677", source="MESH:D007634", source="MONDO:Redundant", source="NCIT:C26805/inferred"} ! corneal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000964 ! cornea +relationship: disease_has_inflammation_site UBERON:0000964 ! cornea +property_value: exactMatch DOID:4677 +property_value: exactMatch http://identifiers.org/mesh/D007634 +property_value: exactMatch http://identifiers.org/snomedct/5888003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022568 +property_value: exactMatch https://icd.codes/icd10cm/H16 +property_value: exactMatch NCIT:C26805 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003090 +name: extrahepatic bile duct carcinoma +def: "A carcinoma that arises from epithelial cells of the extrahepatic bile duct." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of extrahepatic bile duct" EXACT [MONDO:patterns/carcinoma, NCIT:C3860] +synonym: "carcinoma of the extrahepatic bile duct" EXACT [NCIT:C3860] +synonym: "extrahepatic bile duct cancer" EXACT [DOID:4682, NCIT:C3860] +synonym: "extrahepatic bile duct carcinoma" EXACT [MONDO:patterns/location, NCIT:C3860] +xref: DOID:4682 {source="MONDO:equivalentTo"} +xref: NCIT:C3860 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4682"} +xref: SCTID:372101000 {source="MONDO:equivalentTo", source="DOID:4682"} +xref: UMLS:C0238019 {source="MONDO:equivalentTo", source="NCIT:C3860", source="DOID:4682"} +is_a: MONDO:0005496 {source="DOID:4682", source="MONDO:Redundant", source="NCIT:C3860"} ! bile duct carcinoma +is_a: MONDO:0021321 {source="MONDO:Redundant", source="NCIT:C3860"} ! malignant tumor of extrahepatic bile duct +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003703 ! extrahepatic bile duct +property_value: exactMatch DOID:4682 +property_value: exactMatch http://identifiers.org/snomedct/372101000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238019 +property_value: exactMatch NCIT:C3860 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003097 +name: childhood mediastinal neurogenic neoplasm +synonym: "childhood mediastinal neurogenic neoplasm" EXACT [NCIT:C5429] +synonym: "childhood mediastinal neurogenic tumor" EXACT [NCIT:C5429] +synonym: "childhood neurogenic neoplasm of mediastinum" EXACT [NCIT:C5429] +synonym: "childhood neurogenic neoplasm of the mediastinum" EXACT [NCIT:C5429] +synonym: "childhood neurogenic tumor of mediastinum" EXACT [NCIT:C5429] +synonym: "childhood neurogenic tumor of the mediastinum" EXACT [NCIT:C5429] +synonym: "pediatric mediastinal neurogenic neoplasm" EXACT [NCIT:C5429] +synonym: "pediatric mediastinal neurogenic tumor" EXACT [NCIT:C5429] +synonym: "pediatric neurogenic neoplasm of mediastinum" EXACT [NCIT:C5429] +synonym: "pediatric neurogenic neoplasm of the mediastinum" EXACT [NCIT:C5429] +synonym: "pediatric neurogenic tumor of mediastinum" EXACT [DOID:4690, NCIT:C5429] +synonym: "pediatric neurogenic tumor of the mediastinum" EXACT [NCIT:C5429] +xref: DOID:4690 {source="MONDO:equivalentTo"} +xref: NCIT:C5429 {source="MONDO:equivalentTo", source="DOID:4690"} +xref: UMLS:C1332981 {source="MONDO:equivalentTo", source="DOID:4690", source="NCIT:C5429"} +is_a: MONDO:0003098 {source="DOID:4690", source="MONDO:Redundant", source="NCIT:C5429"} ! mediastinal neural neoplasm +is_a: MONDO:0021079 {source="MONDO:Redundant", source="NCIT:C5429"} ! childhood neoplasm +intersection_of: MONDO:0003098 {source="NCIT:C5429"} ! mediastinal neural neoplasm +intersection_of: has_modifier HP:0011463 {source="NCIT:C5429"} ! Childhood onset +property_value: exactMatch DOID:4690 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332981 +property_value: exactMatch NCIT:C5429 + +[Term] +id: MONDO:0003098 +name: mediastinal neural neoplasm +def: "A neurogenic tumor that arises from the mediastinum. Neural tumors are the most common tumors that arise from the posterior mediastinum. Representative examples include Schwannoma, neurofibroma, and neuroblastoma." [NCIT:C6624] +synonym: "malignant mediastinal neurogenic neoplasm" RELATED [DOID:4691] +synonym: "mediastinal neural neoplasm" EXACT [NCIT:C6624] +synonym: "mediastinal neural tumor" EXACT [NCIT:C6624] +synonym: "mediastinal neurogenic neoplasm" EXACT [NCIT:C6624] +synonym: "mediastinal neurogenic tumor" EXACT [NCIT:C6624] +synonym: "neurogenic neoplasm of mediastinum" EXACT [NCIT:C6624] +synonym: "neurogenic neoplasm of the mediastinum" EXACT [NCIT:C6624] +synonym: "neurogenic tumor of mediastinum" EXACT [DOID:4691, NCIT:C6624] +synonym: "neurogenic tumor of the mediastinum" EXACT [NCIT:C6624] +xref: DOID:4691 {source="MONDO:equivalentTo"} +xref: NCIT:C6624 {source="MONDO:equivalentTo", source="DOID:4691"} +xref: UMLS:C1334672 {source="MONDO:equivalentTo", source="NCIT:C6624", source="DOID:4691"} +is_a: MONDO:0001406 ! peripheral nervous system neoplasm +is_a: MONDO:0021386 {source="MONDO:Redundant", source="NCIT:C6624"} ! neoplasm of mediastinum +intersection_of: MONDO:0005070 {source="NCIT:C6624"} ! neoplasm +intersection_of: disease_has_location UBERON:0001021 {source="NCIT:C6624"} ! nerve +intersection_of: disease_has_location UBERON:0003728 {source="NCIT:C6624"} ! mediastinum +relationship: disease_has_location UBERON:0001021 ! nerve +property_value: exactMatch DOID:4691 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334672 +property_value: exactMatch NCIT:C6624 + +[Term] +id: MONDO:0003100 +name: nerve plexus neoplasm +def: "A neoplasm (disease) that involves the nerve plexus." [MONDO:patterns/location] +synonym: "neoplasm of nerve plexus" EXACT [MONDO:patterns/neoplasm, NCIT:C5822] +synonym: "neoplasm of the nerve plexus" EXACT [NCIT:C5822] +synonym: "nerve plexus neoplasm" EXACT [NCIT:C5822] +synonym: "nerve plexus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nerve plexus neoplasms" EXACT [NCIT:C5822] +synonym: "nerve plexus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5822] +synonym: "nerve plexus tumors" EXACT [NCIT:C5822] +synonym: "neural plexus neoplasms" EXACT [NCIT:C5822] +synonym: "neural plexus tumors" EXACT [DOID:4693, NCIT:C5822] +synonym: "tumor of nerve plexus" EXACT [MONDO:patterns/neoplasm, NCIT:C5822] +synonym: "tumor of the nerve plexus" EXACT [NCIT:C5822] +xref: DOID:4693 {source="MONDO:equivalentTo"} +xref: NCIT:C5822 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4693"} +xref: UMLS:C1334945 {source="MONDO:equivalentTo", source="NCIT:C5822", source="DOID:4693"} +is_a: MONDO:0001406 {source="DOID:4693", source="MONDO:Redundant", source="NCIT:C5822"} ! peripheral nervous system neoplasm +is_a: MONDO:0024432 ! nerve plexus disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001810 ! nerve plexus +property_value: exactMatch DOID:4693 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334945 +property_value: exactMatch NCIT:C5822 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003104 +name: epicardium cancer +def: "A malignant neoplasm involving the epicardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of epicardium" EXACT [MONDO:patterns/cancer] +synonym: "epicardial tumor" BROAD [DOID:4699, NCIT:C5347] +synonym: "epicardium cancer" EXACT [MONDO:patterns/location] +synonym: "malignant epicardial neoplasm" EXACT [NCIT:C4568] +synonym: "malignant epicardial tumor" EXACT [DOID:4699, NCIT:C4568] +synonym: "malignant epicardium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of epicardium" EXACT [DOID:4699, MONDO:patterns/cancer, NCIT:C4568] +synonym: "malignant neoplasm of the epicardium" EXACT [NCIT:C4568] +synonym: "malignant tumor of epicardium" EXACT [NCIT:C4568] +synonym: "malignant tumor of the epicardium" EXACT [NCIT:C4568] +xref: DOID:4699 {source="MONDO:equivalentTo"} +xref: NCIT:C4568 {source="MONDO:equivalentTo"} +xref: UMLS:C2607932 {source="MONDO:equivalentTo", source="NCIT:C4568"} +is_a: MONDO:0001322 {source="DOID:4699", source="MONDO:Entailed", source="MONDO:Redundant"} ! pericardium cancer +is_a: MONDO:0021379 {source="MONDO:Redundant", source="NCIT:C4568"} ! neoplasm of epicardium +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002348 ! epicardium +property_value: exactMatch DOID:4699 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2607932 +property_value: exactMatch NCIT:C4568 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003105 +name: prostate disorder +def: "A disease involving the prostate gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of prostate gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of prostate gland" EXACT [] +synonym: "disorder of prostate gland" EXACT [MONDO:patterns/location_top] +synonym: "prostate disease" EXACT [NCIT:C26865] +synonym: "prostate disorder" EXACT [NCIT:C26865] +synonym: "prostate gland disease" EXACT [MONDO:patterns/location] +synonym: "prostate gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:47 {source="MONDO:equivalentTo"} +xref: ICD9:602.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:602.9 {source="MONDO:equivalentTo", source="DOID:47", source="MONDO:i2s"} +xref: MESH:D011469 {source="MONDO:equivalentTo", source="DOID:47"} +xref: NCIT:C26865 {source="MONDO:equivalentTo", source="DOID:47"} +xref: SCTID:30281009 {source="MONDO:equivalentTo", source="DOID:47"} +xref: UMLS:C0033575 {source="MONDO:equivalentTo", source="DOID:47", source="NCIT:C26865"} +is_a: MONDO:0003150 {source="DOID:47", source="MESH:D011469", source="MONDO:Redundant", source="NCIT:C26865"} ! male reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +relationship: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:47 +property_value: exactMatch http://identifiers.org/mesh/D011469 +property_value: exactMatch http://identifiers.org/snomedct/30281009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0033575 +property_value: exactMatch NCIT:C26865 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003107 +name: infratentorial cancer +def: "Malignant neoplasms which arise or occur within the intracranial cavity below the tentorium cerebelli. This includes neoplasms within the brain and/or surrounding spaces." [NCIT:P378] +synonym: "brain neoplasm, infratentorial" EXACT [DOID:4706, NCIT:C3139] +synonym: "infratentorial neoplasms, malignant" EXACT [NCIT:C4966] +synonym: "malignant infratentorial neoplasm" EXACT [NCIT:C4966] +synonym: "malignant infratentorial tumor" EXACT [NCIT:C4966] +synonym: "malignant infratentorial tumors" EXACT [DOID:4706, NCIT:C4966] +xref: DOID:4706 {source="MONDO:equivalentTo"} +xref: MESH:D015192 {source="MONDO:equivalentTo", source="DOID:4706"} +xref: NCIT:C4966 {source="MONDO:equivalentTo", source="DOID:4706"} +xref: UMLS:C0751593 {source="MONDO:equivalentTo", source="NCIT:C4966", source="DOID:4706"} +is_a: MONDO:0001657 {source="DOID:4706", source="MESH:D015192", source="NCIT:C4966"} ! brain cancer +property_value: exactMatch DOID:4706 +property_value: exactMatch http://identifiers.org/mesh/D015192 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751593 +property_value: exactMatch NCIT:C4966 + +[Term] +id: MONDO:0003109 +name: foramen magnum meningioma +def: "A meningioma that affects the foramen magnum." [NCIT:P378] +synonym: "foramen magnum meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of foramen magnum" EXACT [] +synonym: "meningioma of Foramen magnum" EXACT [NCIT:C5280] +synonym: "meningioma of the Foramen magnum" EXACT [DOID:4708, NCIT:C5280] +xref: DOID:4708 {source="MONDO:equivalentTo"} +xref: NCIT:C5280 {source="MONDO:equivalentTo", source="DOID:4708"} +xref: UMLS:C1333630 {source="MONDO:equivalentTo", source="NCIT:C5280", source="DOID:4708"} +is_a: MONDO:0002998 {source="DOID:4708", source="NCIT:C5280"} ! skull base meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0003687 ! foramen magnum +relationship: disease_has_location UBERON:0003687 ! foramen magnum +property_value: exactMatch DOID:4708 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333630 +property_value: exactMatch NCIT:C5280 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003111 +name: gastric neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the stomach. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5696] +comment: Some subtypes are malignant. +synonym: "gastric neuroendocrine neoplasm" EXACT [NCIT:C5696] +synonym: "NET of stomach" EXACT [Orphanet:100075] +synonym: "neuroendocrine neoplasm of stomach" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5696] +synonym: "neuroendocrine neoplasm of the stomach" EXACT [NCIT:C5696] +synonym: "neuroendocrine tumor of stomach" RELATED [Orphanet:100075] +synonym: "neuroendocrine tumor of the stomach" EXACT [DOID:4715, NCIT:C5696] +synonym: "stomach NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "stomach neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5696] +synonym: "stomach neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "stomach neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: DOID:4715 {source="MONDO:equivalentTo"} +xref: NCIT:C5696 {source="MONDO:equivalentTo", source="DOID:4715", source="MONDO:exact-label-match"} +xref: Orphanet:100075 {source="MONDO:equivalentTo"} +xref: SCTID:721194008 {source="MONDO:equivalentTo"} +xref: UMLS:C1333783 {source="MONDO:equivalentTo", source="NCIT:C5696", source="DOID:4715"} +is_a: MONDO:0021085 {source="MONDO:Redundant", source="NCIT:C5696"} ! gastric neoplasm +is_a: MONDO:0024503 ! digestive system neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:4715 +property_value: exactMatch http://identifiers.org/snomedct/721194008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333783 +property_value: exactMatch NCIT:C5696 +property_value: exactMatch Orphanet:100075 +property_value: excluded_subClassOf MONDO:0002891 {source="DOID:4715"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0003112 +name: malignant gastric germ cell tumor +def: "A malignant germ cell tumor that arises from the stomach. It includes choriocarcinoma and immature teratoma." [NCIT:C5486] +synonym: "germ cell tumor of the stomach" EXACT [DOID:4716, NCIT:C6448] +synonym: "malignant gastric germ cell neoplasm" EXACT [NCIT:C5486] +synonym: "malignant gastric germ cell tumor" EXACT [NCIT:C5486] +synonym: "malignant germ cell neoplasm of stomach" EXACT [NCIT:C5486] +synonym: "malignant germ cell neoplasm of the stomach" EXACT [NCIT:C5486] +synonym: "malignant germ cell tumor of stomach" EXACT [NCIT:C5486] +synonym: "malignant germ cell tumor of the stomach" EXACT [NCIT:C5486] +xref: DOID:4716 {source="MONDO:equivalentTo"} +xref: NCIT:C5486 {source="MONDO:equivalentTo"} +xref: UMLS:C1333769 {source="MONDO:equivalentTo", source="DOID:4716"} +xref: UMLS:C1334584 {source="NCIT:C5486", source="MONDO:equivalentTo"} +is_a: MONDO:0001056 {source="DOID:4716", source="MONDO:Redundant", source="NCIT:C5486"} ! gastric cancer +is_a: MONDO:0003113 {source="NCIT:C5486"} ! extragonadal germ cell cancer +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:4716 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333769 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334584 +property_value: exactMatch NCIT:C5486 + +[Term] +id: MONDO:0003113 +name: extragonadal germ cell cancer +def: "A malignant germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary." [NCIT:C8881] +synonym: "extragonadal germ cell malignant tumor" EXACT [DOID:4717] +synonym: "extragonadal germ cell tumor, malignant" EXACT [MONDO:patterns/malignant] +synonym: "malignant extragonadal germ cell tumor" EXACT [NCIT:C8881] +synonym: "malignant neoplasm of extragonadal germ cell" EXACT [NCIT:C8881] +synonym: "malignant neoplasm of the extragonadal germ cell" EXACT [NCIT:C8881] +synonym: "malignant tumor of extragonadal germ cell" EXACT [NCIT:C8881] +synonym: "malignant tumor of the extragonadal germ cell" EXACT [NCIT:C8881] +synonym: "tumor of extragonadal germ cell" RELATED [DOID:4717] +xref: DOID:4717 {source="MONDO:equivalentTo"} +xref: NCIT:C8881 {source="MONDO:equivalentTo", source="DOID:4717"} +xref: UMLS:C1334581 {source="MONDO:equivalentTo", source="DOID:4717"} +is_a: MONDO:0006290 {source="MONDO:Redundant", source="NCIT:C8881"} ! malignant germ cell tumor +is_a: MONDO:0018201 {source="MONDO:Redundant", source="NCIT:C8881"} ! extragonadal germ cell tumor +intersection_of: MONDO:0018201 ! extragonadal germ cell tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch DOID:4717 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334581 +property_value: exactMatch NCIT:C8881 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0003121 +name: middle cranial fossa meningioma +def: "A meningioma that affects the middle cranial fossa." [NCIT:P378] +synonym: "meningioma (disease) of middle cranial fossa" EXACT [] +synonym: "meningioma of middle cranial fossa" EXACT [NCIT:C5586] +synonym: "meningioma of the middle cranial fossa" EXACT [DOID:4749, NCIT:C5586] +synonym: "middle cranial fossa meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:4749 {source="MONDO:equivalentTo"} +xref: NCIT:C5586 {source="MONDO:equivalentTo", source="DOID:4749"} +xref: UMLS:C1334757 {source="MONDO:equivalentTo", source="NCIT:C5586", source="DOID:4749"} +is_a: MONDO:0016642 {source="DOID:4749", source="MONDO:Redundant", source="NCIT:C5586/inferred"} ! meningioma +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0003722 ! middle cranial fossa +relationship: disease_has_location UBERON:0003722 ! middle cranial fossa +property_value: exactMatch DOID:4749 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334757 +property_value: exactMatch NCIT:C5586 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003125 +name: testicular sex cord-stromal neoplasm +def: "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group." [NCIT:C6358] +subset: ordo_disease {source="Orphanet:363489"} +synonym: "sex cord-stromal neoplasm" RELATED [DOID:4757] +synonym: "sex cord-stromal neoplasm of testis" RELATED [NCIT:C6358] +synonym: "sex cord-stromal neoplasm of the testis" RELATED [NCIT:C6358] +synonym: "sex cord-stromal tumor of testis" EXACT [DOID:4757, NCIT:C6358, Orphanet:363489] +synonym: "sex cord-stromal tumor of the testis" RELATED [NCIT:C6358] +synonym: "testicular sex cord-stromal neoplasm" EXACT [NCIT:C6358] +synonym: "testicular sex cord-stromal tumor" EXACT [NCIT:C6358, Orphanet:363489] +synonym: "testis sex cord-stromal tumor" EXACT [MONDO:patterns/location] +xref: DOID:4757 {source="MONDO:equivalentTo"} +xref: ICD10CM:C62.1 {source="Orphanet:363489", source="Orphanet:363489/ntbt"} +xref: NCIT:C6358 {source="MONDO:equivalentTo", source="DOID:4757", source="NCIT:C6358"} +xref: Orphanet:363489 {source="MONDO:equivalentTo"} +xref: SCTID:702406000 {source="MONDO:equivalentTo", source="DOID:4757"} +xref: UMLS:C3840076 {source="MONDO:equivalentTo", source="DOID:4757", source="NCIT:C6358"} +xref: UMLS:CN204701 {source="MONDO:equivalentTo"} +is_a: MONDO:0006055 {source="DOID:4757", source="MONDO:Redundant", source="NCIT:C6358"} ! sex cord-stromal tumor +is_a: MONDO:0018191 {source="Orphanet:363489"} ! tumor of testis and paratestis +is_a: MONDO:0021348 {source="MONDO:Redundant", source="NCIT:C6358"} ! neoplasm of testis +intersection_of: MONDO:0006055 ! sex cord-stromal tumor +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:4757 +property_value: exactMatch http://identifiers.org/snomedct/702406000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3840076 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204701 +property_value: exactMatch NCIT:C6358 +property_value: exactMatch Orphanet:363489 +property_value: narrowMatch https://icd.codes/icd10cm/C62.1 + +[Term] +id: MONDO:0003150 +name: male reproductive system disorder +def: "A disease involving the male reproductive system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of male reproductive system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of male reproductive system" EXACT [] +synonym: "disorder of Male reproductive system" EXACT [NCIT:C27019] +synonym: "disorder of male reproductive system" EXACT [MONDO:patterns/location_top] +synonym: "male reproductive disease" EXACT [DOID:48] +synonym: "Male reproductive system disease" EXACT [NCIT:C27019] +synonym: "male reproductive system disease" EXACT [MONDO:patterns/location] +synonym: "male reproductive system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "Male reproductive system disorder" EXACT [NCIT:C27019] +xref: DOID:48 {source="MONDO:equivalentTo"} +xref: ICD10CM:N40-N53 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10WHO:N40-N51 {source="MONDO:equivalentTo"} +xref: ICD9:600-608.99 {source="DOID:48"} +xref: ICD9:608.9 {source="DOID:48"} +xref: MESH:D005832 {source="DOID:48", source="MONDO:equivalentTo"} +xref: NCIT:C27019 {source="MONDO:equivalentTo"} +xref: SCTID:363194005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005039 {source="DOID:48", source="MONDO:Redundant", source="NCIT:C27019"} ! reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000079 ! male reproductive system +relationship: disease_has_location UBERON:0000079 ! male reproductive system +property_value: exactMatch DOID:48 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/N40-N51 +property_value: exactMatch http://identifiers.org/mesh/D005832 +property_value: exactMatch http://identifiers.org/snomedct/363194005 +property_value: exactMatch https://icd.codes/icd10cm/N40-N53 +property_value: exactMatch NCIT:C27019 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003165 +name: cerebellar astrocytoma +def: "Benign and malignant neoplasms of the cerebellum that arise from astrocytes. During childhood the majority are benign pilocytic astrocytomas. In adults both benign and relatively higher grade forms may occur. The most common presenting symptoms are headache, nausea, vomiting, ataxia of gait or limb, paresis, diplopia, and dizziness. Objective signs include weakness, long tract signs, dysmetria, gait ataxia, papilledema, and nystagmus. Surgical resection is often curative." [NCIT:C9475] +synonym: "astrocytoma (excluding glioblastoma) of cerebellum" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of cerebellum" EXACT [DOID:4848, NCIT:C9475] +synonym: "astrocytoma of the cerebellum" EXACT [NCIT:C9475] +synonym: "astrocytoma, cerebellar" EXACT [NCIT:C9475] +synonym: "cerebellar astrocytoma" EXACT [NCIT:C9475] +synonym: "cerebellum astrocytoma" EXACT [MONDO:patterns/location] +synonym: "cerebellum astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: DOID:4848 {source="MONDO:equivalentTo"} +xref: NCIT:C9475 {source="MONDO:equivalentTo", source="DOID:4848"} +xref: UMLS:C0740480 {source="NCIT:C9475", source="MONDO:equivalentTo", source="DOID:4848"} +is_a: MONDO:0002913 {source="DOID:4848", source="MONDO:Redundant"} ! cerebellar neoplasm +is_a: MONDO:0021631 {source="MONDO:Redundant", source="NCIT:C9475"} ! brain astrocytoma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch DOID:4848 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0740480 +property_value: exactMatch NCIT:C9475 +property_value: excluded_subClassOf MONDO:0005499 {source="DOID:4848"} + +[Term] +id: MONDO:0003169 +name: diencephalic astrocytomas +def: "A astrocytoma that involves the diencephalon." [MONDO:patterns/location] +synonym: "astrocytoma (excluding glioblastoma) of diencephalon" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of diencephalon" EXACT [DOID:4855, NCIT:C5128] +synonym: "astrocytoma of the diencephalon" EXACT [NCIT:C5128] +synonym: "diencephalic astrocytoma" EXACT [NCIT:C5128] +synonym: "diencephalon astrocytoma" EXACT [MONDO:patterns/location] +synonym: "diencephalon astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: DOID:4855 {source="MONDO:equivalentTo"} +xref: NCIT:C5128 {source="DOID:4855", source="MONDO:equivalentTo"} +xref: UMLS:C1333284 {source="DOID:4855", source="MONDO:equivalentTo", source="NCIT:C5128"} +is_a: MONDO:0002786 {source="DOID:4855", source="MONDO:Entailed", source="MONDO:Redundant"} ! diencephalic cancer +is_a: MONDO:0005499 {source="DOID:4855", source="MONDO:Entailed", source="MONDO:Redundant"} ! brain glioma +is_a: MONDO:0021631 {source="MONDO:Redundant", source="NCIT:C5128"} ! brain astrocytoma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0001894 ! diencephalon +property_value: exactMatch DOID:4855 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333284 +property_value: exactMatch NCIT:C5128 + +[Term] +id: MONDO:0003171 +name: pineal gland astrocytoma +def: "A astrocytoma that involves the pineal body." [MONDO:patterns/location] +synonym: "astrocytoma (excluding glioblastoma) of pineal body" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of pineal gland" EXACT [NCIT:C8274] +synonym: "astrocytoma of the pineal gland" EXACT [NCIT:C8274] +synonym: "pineal astrocytic tumor" EXACT [DOID:4858, NCIT:C8274] +synonym: "pineal astrocytoma" EXACT [NCIT:C8274] +synonym: "pineal body astrocytoma" EXACT [MONDO:patterns/location] +synonym: "pineal body astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: DOID:4858 {source="MONDO:equivalentTo"} +xref: NCIT:C8274 {source="MONDO:equivalentTo", source="DOID:4858"} +xref: UMLS:C0280795 {source="MONDO:equivalentTo", source="DOID:4858", source="NCIT:C8274"} +is_a: MONDO:0003169 ! diencephalic astrocytomas +is_a: MONDO:0003249 {source="DOID:4858", source="MONDO:Entailed", source="MONDO:Redundant"} ! pineal gland cancer +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0001905 ! pineal body +property_value: exactMatch DOID:4858 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280795 +property_value: exactMatch NCIT:C8274 + +[Term] +id: MONDO:0003173 +name: brain stem astrocytic neoplasm +def: "An astrocytoma that arises from the brain stem." [NCIT:P378] +synonym: "astrocytoma (excluding glioblastoma) of brainstem" EXACT [MONDO:design_pattern] +synonym: "brain stem astrocytoma" EXACT [NCIT:C7445] +synonym: "brainstem astrocytoma" EXACT [DOID:4860, MONDO:patterns/location, NCIT:C7445] +synonym: "brainstem astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: DOID:4860 {source="MONDO:equivalentTo"} +xref: NCIT:C7445 {source="DOID:4860", source="MONDO:equivalentTo"} +xref: SCTID:107581000119103 {source="DOID:4860", source="MONDO:equivalentTo"} +xref: UMLS:C1332608 {source="DOID:4860", source="MONDO:equivalentTo", source="NCIT:C7445"} +is_a: MONDO:0002911 {source="DOID:4860", source="NCIT:C7445"} ! brain stem glioma +is_a: MONDO:0021631 {source="MONDO:Redundant", source="NCIT:C7445"} ! brain astrocytoma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch DOID:4860 +property_value: exactMatch http://identifiers.org/snomedct/107581000119103 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332608 +property_value: exactMatch NCIT:C7445 + +[Term] +id: MONDO:0003174 +name: spinal cord astrocytoma +def: "A low or high grade astrocytoma that arises in the spinal cord." [NCIT:C4641] +synonym: "astrocytoma (excluding glioblastoma) of spinal cord" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of spinal cord" EXACT [NCIT:C4641] +synonym: "astrocytoma of the spinal cord" EXACT [NCIT:C4641] +synonym: "spinal astrocytoma" EXACT [DOID:4863, NCIT:C4641] +synonym: "spinal cord astrocytoma" EXACT [MONDO:patterns/location, NCIT:C4641] +synonym: "spinal cord astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: DOID:4863 {source="MONDO:equivalentTo"} +xref: EFO:1000544 {source="MONDO:equivalentTo"} +xref: NCIT:C4641 {source="DOID:4863", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:254948003 {source="DOID:4863", source="MONDO:equivalentTo"} +xref: UMLS:C0349540 {source="DOID:4863", source="MONDO:equivalentTo", source="NCIT:C4641"} +is_a: MONDO:0002542 {source="DOID:4863", source="NCIT:C4641"} ! spinal cord glioma +is_a: MONDO:0019781 {source="DOID:4863", source="MONDO:Redundant", source="NCIT:C4641"} ! astrocytoma (excluding glioblastoma) +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:4863 +property_value: exactMatch http://identifiers.org/snomedct/254948003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349540 +property_value: exactMatch NCIT:C4641 + +[Term] +id: MONDO:0003182 +name: anterior horn disorder +def: "Anterior horn disease is one of a number of medical disorders affecting the anterior horn of the spinal cord. Anterior horn diseases include spinal muscular atrophy, poliomyelitis and amyotrophic lateral sclerosis." [Wikipedia:Anterior_horn_disease] +comment: TODO - check this. DO places as a subtype of SMA, but we invert this. Consider merging into MND +synonym: "disease of ventral horn of spinal cord" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ventral horn of spinal cord" EXACT [] +synonym: "disorder of ventral horn of spinal cord" EXACT [MONDO:patterns/location_top] +synonym: "ventral horn of spinal cord disease" EXACT [MONDO:patterns/location] +synonym: "ventral horn of spinal cord disease or disorder" EXACT [MONDO:patterns/location] +xref: DOID:4873 {source="MONDO:equivalentTo"} +xref: ICD9:335 {source="DOID:4873"} +xref: ICD9:335.9 {source="DOID:4873", source="MONDO:relatedTo"} +is_a: MONDO:0002545 ! spinal cord disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002257 ! ventral horn of spinal cord +relationship: disease_has_location UBERON:0002257 ! ventral horn of spinal cord +property_value: exactMatch DOID:4873 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003184 +name: trachea carcinoma +def: "A carcinoma that arises from epithelial cells of the trachea." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of the trachea" EXACT [NCIT:C9347] +synonym: "cancer of trachea" BROAD [NCIT:C9347] +synonym: "carcinoma of the trachea" EXACT [DOID:4876, NCIT:C9347] +synonym: "carcinoma of trachea" EXACT [MONDO:patterns/carcinoma, NCIT:C9347] +synonym: "trachea cancer" BROAD [NCIT:C9347] +synonym: "trachea carcinoma" EXACT [MONDO:patterns/location, NCIT:C9347] +synonym: "tracheal carcinoma" EXACT [NCIT:C9347] +xref: DOID:4876 {source="MONDO:equivalentTo"} +xref: EFO:1000599 {source="MONDO:equivalentTo"} +xref: NCIT:C9347 {source="MONDO:equivalentTo", source="EFO:1000599"} +xref: UMLS:C1744708 {source="NCIT:C9347", source="MONDO:equivalentTo"} +is_a: MONDO:0001407 {source="DOID:4876", source="MONDO:Redundant", source="NCIT:C9347"} ! tracheal cancer +is_a: MONDO:0004993 {source="DOID:4876", source="EFO:1000599", source="MONDO:Redundant", source="NCIT:C9347"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch DOID:4876 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1744708 +property_value: exactMatch NCIT:C9347 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003189 +name: middle ear adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the middle ear" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of middle Ear" EXACT [NCIT:C6848] +synonym: "adenocarcinoma of middle ear" RELATED [DOID:4892] +synonym: "adenocarcinoma of the middle Ear" EXACT [NCIT:C6848] +synonym: "adenocarcinoma of the middle ear" EXACT [DOID:4892, NCIT:C6848] +synonym: "middle Ear adenocarcinoma" EXACT [NCIT:C6848] +synonym: "middle ear adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4892 {source="MONDO:equivalentTo"} +xref: NCIT:C6848 {source="DOID:4892", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334758 {source="DOID:4892", source="MONDO:equivalentTo", source="NCIT:C6848"} +is_a: MONDO:0003190 {source="DOID:4892", source="MONDO:Redundant", source="NCIT:C6848"} ! middle ear carcinoma +is_a: MONDO:0004970 {source="DOID:4892", source="MONDO:Redundant", source="NCIT:C6848"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch DOID:4892 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334758 +property_value: exactMatch NCIT:C6848 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003190 +name: middle ear carcinoma +def: "A carcinoma that arises from epithelial cells of the middle ear" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of middle Ear" EXACT [NCIT:C6089] +synonym: "carcinoma of middle ear" EXACT [DOID:4893, MONDO:patterns/carcinoma] +synonym: "carcinoma of the middle Ear" EXACT [NCIT:C6089] +synonym: "carcinoma of the middle ear" EXACT [DOID:4893, NCIT:C6089] +synonym: "middle Ear carcinoma" EXACT [NCIT:C6089] +synonym: "middle ear carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4893 {source="MONDO:equivalentTo"} +xref: NCIT:C6089 {source="DOID:4893", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334760 {source="DOID:4893", source="NCIT:C6089", source="MONDO:equivalentTo"} +is_a: MONDO:0002038 {source="MONDO:Redundant", source="NCIT:C6089/inferred"} ! head and neck carcinoma +is_a: MONDO:0003275 {source="DOID:4893", source="MONDO:Redundant", source="NCIT:C6089"} ! middle ear cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch DOID:4893 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334760 +property_value: exactMatch NCIT:C6089 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003191 +name: rete ovarii adenocarcinoma +def: "An exceptionally rare adenocarcinoma that arises from the rete ovarii." [NCIT:C40017] +synonym: "rete ovarii adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C40017] +xref: DOID:4894 {source="MONDO:equivalentTo"} +xref: NCIT:C40017 {source="DOID:4894", source="MONDO:equivalentTo"} +xref: UMLS:C3840223 {source="NCIT:C40017", source="DOID:4894", source="MONDO:equivalentTo"} +is_a: MONDO:0002752 {source="DOID:4894", source="MONDO:Entailed", source="MONDO:Redundant"} ! ovarian adenocarcinoma +is_a: MONDO:0003192 {source="MONDO:Redundant", source="NCIT:C40017"} ! rete ovarii neoplasm +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0010185 ! rete ovarii +property_value: exactMatch DOID:4894 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3840223 +property_value: exactMatch NCIT:C40017 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003192 +name: rete ovarii neoplasm +def: "A benign or malignant neoplasm that arises from the rete ovarii which is located in the ovarian hilus. It includes adenoma, cystadenoma, cystadenofibroma, and adenocarcinoma." [NCIT:C40016] +synonym: "neoplasm of rete ovarii" EXACT [MONDO:patterns/neoplasm] +synonym: "rete ovarii neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "rete ovarii tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of rete ovarii" EXACT [MONDO:patterns/neoplasm] +xref: DOID:4895 {source="MONDO:equivalentTo"} +xref: NCIT:C40016 {source="DOID:4895", source="MONDO:equivalentTo"} +xref: UMLS:C1514909 {source="DOID:4895", source="MONDO:equivalentTo", source="NCIT:C40016"} +is_a: MONDO:0021068 ! ovarian neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0010185 ! rete ovarii +relationship: disease_has_location UBERON:0010185 ! rete ovarii +property_value: exactMatch DOID:4895 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514909 +property_value: exactMatch NCIT:C40016 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003193 +name: bile duct adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the bile duct" [https://orcid.org/0000-0002-6601-2165] +synonym: "bile duct adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C27813] +xref: DOID:4896 {source="MONDO:equivalentTo"} +xref: NCIT:C27813 {source="DOID:4896", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1370800 {source="DOID:4896", source="MONDO:equivalentTo", source="NCIT:C27813"} +is_a: MONDO:0005496 {source="DOID:4896", source="MONDO:Redundant", source="NCIT:C27813"} ! bile duct carcinoma +is_a: MONDO:0018532 ! adenocarcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch DOID:4896 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1370800 +property_value: exactMatch NCIT:C27813 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003196 +name: appendix carcinoma +def: "A carcinoma that arises from epithelial cells of the vermiform appendix" [https://orcid.org/0000-0002-6601-2165] +synonym: "appendix cancer" BROAD [NCIT:C9330] +synonym: "appendix carcinoma" EXACT [NCIT:C9330] +synonym: "Ca appendix" EXACT [DOID:4902] +synonym: "carcinoma of appendix" EXACT [DOID:4902, NCIT:C9330] +synonym: "carcinoma of the appendix" EXACT [NCIT:C9330] +synonym: "carcinoma of vermiform appendix" EXACT [MONDO:patterns/carcinoma] +synonym: "vermiform appendix carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4902 {source="MONDO:equivalentTo"} +xref: NCIT:C9330 {source="MONDO:equivalentTo", source="DOID:4902"} +xref: SCTID:448992002 {source="MONDO:equivalentTo"} +xref: UMLS:C0728951 {source="MONDO:equivalentTo", source="DOID:4902"} +is_a: MONDO:0001235 {source="DOID:4902", source="MONDO:Redundant", source="NCIT:C9330"} ! appendix cancer +is_a: MONDO:0006029 ! cecum carcinoma +is_a: MONDO:0018511 ! epithelial tumor of the appendix +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:4902 +property_value: exactMatch http://identifiers.org/snomedct/448992002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0728951 +property_value: exactMatch NCIT:C9330 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003198 +name: small intestine adenocarcinoma +def: "An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma." [NCIT:C7888] +subset: ordo_disease {source="Orphanet:104075"} +synonym: "adenocarcinoma - small intest." EXACT [NCIT:C7888] +synonym: "adenocarcinoma of small bowel" EXACT [NCIT:C7888, Orphanet:104075] +synonym: "adenocarcinoma of small instestine" EXACT [MONDO:0015189] +synonym: "adenocarcinoma of small intestine" EXACT [DOID:4906, NCIT:C7888] +synonym: "adenocarcinoma of the small bowel" EXACT [NCIT:C7888] +synonym: "adenocarcinoma of the small instestine" RELATED [Orphanet:104075] +synonym: "adenocarcinoma of the small intestine" EXACT [NCIT:C7888] +synonym: "small bowel adenocarcinoma" EXACT [NCIT:C7888] +synonym: "small intestinal adenocarcinoma" EXACT [DOID:4906, MONDO:0006415, NCIT:C7888] +synonym: "small intestine adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4906 {source="MONDO:equivalentTo"} +xref: EFO:1000532 {source="MONDO:equivalentTo"} +xref: GARD:0013090 {source="MONDO:equivalentTo"} +xref: ICD10CM:D01.4 {source="Orphanet:104075", source="Orphanet:104075/ntbt"} +xref: NCIT:C7888 {source="MONDO:equivalentTo", source="DOID:4906"} +xref: Orphanet:104075 {source="MONDO:equivalentTo"} +xref: SCTID:424440001 {source="MONDO:equivalentTo", source="DOID:4906"} +xref: UMLS:C0278803 {source="MONDO:equivalentTo", source="NCIT:C7888", source="Orphanet:104075", source="DOID:4906"} +is_a: MONDO:0004970 {source="DOID:4906", source="EFO:1000532", source="MONDO:Redundant", source="NCIT:C7888"} ! adenocarcinoma +is_a: MONDO:0005522 {source="DOID:4906", source="MONDO:Redundant", source="NCIT:C7888", source="Orphanet:104075"} ! small intestine carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:4906 +property_value: exactMatch http://identifiers.org/snomedct/424440001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278803 +property_value: exactMatch NCIT:C7888 +property_value: exactMatch Orphanet:104075 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/D01.4 + +[Term] +id: MONDO:0003199 +name: anal carcinoma +def: "A carcinoma that arises from epithelial cells of the anus" [https://orcid.org/0000-0002-6601-2165] +synonym: "anal cancer" BROAD [NCIT:C9291] +synonym: "anal carcinoma" EXACT [NCIT:C9291] +synonym: "anus carcinoma" EXACT [MONDO:patterns/location] +synonym: "Ca anus" BROAD [DOID:4908] +synonym: "cancer of anus" BROAD [NCIT:C9291] +synonym: "cancer of the anus" BROAD [NCIT:C9291] +synonym: "carcinoma of anus" EXACT [DOID:4908, MONDO:patterns/carcinoma, NCIT:C9291] +synonym: "carcinoma of the anus" EXACT [NCIT:C9291] +xref: DOID:4908 {source="MONDO:equivalentTo"} +xref: NCIT:C9291 {source="DOID:4908", source="MONDO:equivalentTo"} +xref: SCTID:448315008 {source="MONDO:equivalentTo"} +xref: UMLS:C0279637 {source="DOID:4908", source="MONDO:equivalentTo", source="NCIT:C9291"} +is_a: MONDO:0001879 {source="DOID:4908", source="MONDO:Redundant", source="NCIT:C9291"} ! anus cancer +is_a: MONDO:0044937 ! rectal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:4908 +property_value: exactMatch http://identifiers.org/snomedct/448315008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279637 +property_value: exactMatch NCIT:C9291 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003200 +name: urethra adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the urethra" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of the urethra" EXACT [DOID:4910, NCIT:C6167] +synonym: "adenocarcinoma of urethra" EXACT [NCIT:C6167] +synonym: "UAD" RELATED ABBREVIATION [ONCOTREE:UAD] +synonym: "urethra adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6167] +synonym: "urethral adenocarcinoma" EXACT [NCIT:C6167] +xref: DOID:4910 {source="MONDO:equivalentTo"} +xref: NCIT:C6167 {source="DOID:4910", source="MONDO:equivalentTo"} +xref: ONCOTREE:UAD {source="MONDO:equivalentTo"} +xref: UMLS:C1336885 {source="NCIT:C6167", source="DOID:4910", source="MONDO:equivalentTo"} +is_a: MONDO:0004970 {source="DOID:4910", source="MONDO:Redundant", source="NCIT:C6167"} ! adenocarcinoma +is_a: MONDO:0021327 {source="MONDO:Redundant", source="NCIT:C6167"} ! carcinoma of urethra +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:4910 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336885 +property_value: exactMatch NCIT:C6167 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003205 +name: renal pelvis adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the renal pelvis" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of kidney pelvis" EXACT [NCIT:C6143] +synonym: "adenocarcinoma of renal pelvis" EXACT [DOID:4918, NCIT:C6143] +synonym: "adenocarcinoma of the kidney pelvis" EXACT [DOID:4918, NCIT:C6143] +synonym: "adenocarcinoma of the renal pelvis" EXACT [NCIT:C6143] +synonym: "kidney pelvis adenocarcinoma" EXACT [NCIT:C6143] +synonym: "kidney renal pelvis adenocarcinoma" EXACT [NCIT:C6143] +synonym: "renal pelvis adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6143] +xref: DOID:4918 {source="MONDO:equivalentTo"} +xref: NCIT:C6143 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4918"} +xref: UMLS:C1335748 {source="NCIT:C6143", source="MONDO:equivalentTo", source="DOID:4918"} +is_a: MONDO:0005086 {source="DOID:4918", source="MONDO:Redundant"} ! renal cell carcinoma +is_a: MONDO:0005519 {source="DOID:4918", source="MONDO:Redundant", source="NCIT:C6143"} ! renal pelvis carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:4918 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335748 +property_value: exactMatch NCIT:C6143 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003209 +name: thymus gland adenocarcinoma +def: "A rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation." [NCIT:C6459] +synonym: "adenocarcinoma of the Thymus" EXACT [DOID:4923, NCIT:C6459] +synonym: "adenocarcinoma of Thymus" EXACT [NCIT:C6459] +synonym: "thymic adenocarcinoma" EXACT [NCIT:C6459] +synonym: "Thymus adenocarcinoma" EXACT [NCIT:C6459] +synonym: "thymus adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4923 {source="MONDO:equivalentTo"} +xref: NCIT:C6459 {source="MONDO:equivalentTo", source="DOID:4923"} +xref: UMLS:C1336743 {source="MONDO:equivalentTo", source="DOID:4923", source="NCIT:C6459"} +is_a: MONDO:0004970 {source="DOID:4923", source="MONDO:Redundant", source="NCIT:C6459"} ! adenocarcinoma +is_a: MONDO:0006451 {source="DOID:4923", source="MONDO:Redundant", source="NCIT:C6459"} ! thymic carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch DOID:4923 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336743 +property_value: exactMatch NCIT:C6459 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003210 +name: intrahepatic cholangiocarcinoma +def: "A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor." [NCIT:C35417] +subset: gard_rare {source="GARD:0006042"} +synonym: "cholangiocarcinoma, intrahepatic, malignant" EXACT [NCIT:C35417] +synonym: "ICC" EXACT ABBREVIATION [NCIT:C35417] +synonym: "IHCH" RELATED ABBREVIATION [ONCOTREE:IHCH] +synonym: "intrahepatic bile duct cancer (cholangiocarcinoma)" EXACT [NCIT:C35417] +synonym: "intrahepatic bile duct carcinoma" EXACT [NCIT:C35417] +synonym: "intrahepatic carcinoma of bile duct" EXACT [NCIT:C35417] +synonym: "intrahepatic carcinoma of the bile duct" EXACT [NCIT:C35417] +synonym: "intrahepatic cholangiocarcinoma" EXACT [NCIT:C35417] +synonym: "intrahepatic cholangiocarcinoma (bile duct cancer)" EXACT [NCIT:C35417] +synonym: "intrahepatic Cholangiocellular carcinoma" EXACT [NCIT:C35417] +synonym: "peripheral cholangiocarcinoma" EXACT [DOID:4928, NCIT:C35417] +xref: DOID:4928 {source="MONDO:equivalentTo"} +xref: EFO:1001961 {source="MONDO:equivalentTo"} +xref: GARD:0006042 {source="MONDO:equivalentTo"} +xref: NCIT:C35417 {source="MONDO:equivalentTo", source="DOID:4928"} +xref: ONCOTREE:IHCH {source="MONDO:equivalentTo"} +xref: SCTID:109842005 {source="MONDO:equivalentTo", source="DOID:4928"} +xref: UMLS:C0345905 {source="MONDO:equivalentTo", source="DOID:4928", source="NCIT:C35417"} +is_a: MONDO:0001487 ! intrahepatic bile duct cancer +is_a: MONDO:0019087 {source="DOID:4928", source="EFO:1001961", source="MONDO:Redundant", source="NCIT:C35417", source="ONCOTREE:IHCH"} ! cholangiocarcinoma +intersection_of: MONDO:0019087 {source="NCIT:C35417"} ! cholangiocarcinoma +intersection_of: disease_arises_from_structure UBERON:0004823 {source="NCIT:C35417"} ! intrahepatic bile duct epithelium +relationship: disease_arises_from_structure UBERON:0004823 ! intrahepatic bile duct epithelium +property_value: exactMatch DOID:4928 +property_value: exactMatch http://identifiers.org/snomedct/109842005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345905 +property_value: exactMatch NCIT:C35417 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6042/intrahepatic-cholangiocarcinoma xsd:anyURI {source="GARD:0006042"} + +[Term] +id: MONDO:0003211 +name: nasal cavity adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the nasal cavity" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of nasal cavity" EXACT [DOID:4930, NCIT:C6015] +synonym: "adenocarcinoma of the nasal cavity" EXACT [DOID:4930, NCIT:C6015] +synonym: "nasal cavity adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6015] +xref: DOID:4930 {source="MONDO:equivalentTo"} +xref: NCIT:C6015 {source="DOID:4930", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334920 {source="DOID:4930", source="MONDO:equivalentTo", source="NCIT:C6015"} +is_a: MONDO:0003212 {source="DOID:4930", source="MONDO:Redundant", source="NCIT:C6015"} ! nasal cavity carcinoma +is_a: MONDO:0004970 {source="DOID:4930", source="MONDO:Redundant", source="NCIT:C6015"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:4930 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334920 +property_value: exactMatch NCIT:C6015 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003212 +name: nasal cavity carcinoma +def: "A carcinoma that arises from epithelial cells of the nasal cavity" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of nasal cavity" BROAD [DOID:4931, NCIT:C9336] +synonym: "cancer of the nasal cavity" BROAD [NCIT:C9336] +synonym: "carcinoma of nasal cavity" EXACT [DOID:4931, MONDO:patterns/carcinoma, NCIT:C9336] +synonym: "carcinoma of the nasal cavity" EXACT [NCIT:C9336] +synonym: "nasal cavity cancer" BROAD [NCIT:C9336] +synonym: "nasal cavity carcinoma" EXACT [MONDO:patterns/location, NCIT:C9336] +xref: DOID:4931 {source="MONDO:equivalentTo"} +xref: NCIT:C9336 {source="MONDO:equivalentTo", source="DOID:4931"} +xref: SCTID:448990005 {source="MONDO:equivalentTo"} +xref: UMLS:C1377785 {source="MONDO:equivalentTo", source="DOID:4931"} +is_a: MONDO:0001128 {source="DOID:4931", source="MONDO:Redundant", source="NCIT:C9336"} ! nasal cavity cancer +is_a: MONDO:0002038 {source="MONDO:Redundant", source="NCIT:C9336/inferred"} ! head and neck carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:4931 +property_value: exactMatch http://identifiers.org/snomedct/448990005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1377785 +property_value: exactMatch NCIT:C9336 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003214 +name: apocrine adenocarcinoma +def: "A carcinoma with apocrine differentiation arising from the sweat glands. It presents as single or multiple nodular lesions which may be ulcerated or hemorrhagic and is usually in the axilla and less often in the anogenital region. It grows in the dermis and infiltrates subcutaneous tissues. It is characterized by the presence of large cells with abundant eosinophilic cytoplasm and large often vesicular nuclei. Most cases are slow growing tumors and have a prolonged course." [NCIT:P378] +synonym: "apocrine adenocarcinoma (morphologic abnormality)" EXACT [DOID:4933] +synonym: "apocrine carcinoma" EXACT [DOID:4933, NCIT:C4169] +synonym: "apocrine gland adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "apocrine gland carcinoma" EXACT [DOID:4933, NCIT:C4169] +synonym: "carcinoma of apocrine gland" EXACT [NCIT:C4169] +synonym: "carcinoma of the apocrine gland" EXACT [DOID:4933, NCIT:C5575] +xref: DOID:4933 {source="MONDO:equivalentTo"} +xref: GARD:0012138 {source="MONDO:equivalentTo"} +xref: ICDO:8401/3 {source="NCIT:C4169"} +xref: NCIT:C4169 {source="MONDO:equivalentTo"} +xref: UMLS:C0334346 {source="MONDO:equivalentTo", source="DOID:4933"} +xref: UMLS:C1706827 {source="MONDO:equivalentTo", source="NCIT:C4169"} +is_a: MONDO:0003215 {source="DOID:4933", source="NCIT:C4169"} ! apocrine sweat gland cancer +is_a: MONDO:0005524 {source="DOID:4933", source="MONDO:Redundant", source="NCIT:C4169"} ! sweat gland carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0008974 ! apocrine gland +relationship: disease_has_location UBERON:0008974 ! apocrine gland +property_value: exactMatch DOID:4933 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334346 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1706827 +property_value: exactMatch NCIT:C4169 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003215 +name: apocrine sweat gland cancer +def: "A malignant neoplasm involving the apocrine sweat gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "apocrine sweat gland cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of apocrine sweat gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant apocrine neoplasm" EXACT [NCIT:C6800] +synonym: "malignant apocrine neoplasm of skin" EXACT [NCIT:C6800] +synonym: "malignant apocrine neoplasm of the skin" EXACT [NCIT:C6800] +synonym: "malignant apocrine skin neoplasm" EXACT [NCIT:C6800] +synonym: "malignant apocrine skin tumor" EXACT [NCIT:C6800] +synonym: "malignant apocrine sweat gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant apocrine tumor" EXACT [DOID:4934, NCIT:C6800] +synonym: "malignant apocrine tumor of skin" EXACT [NCIT:C6800] +synonym: "malignant apocrine tumor of the skin" EXACT [NCIT:C6800] +synonym: "malignant neoplasm of apocrine sweat gland" EXACT [MONDO:patterns/cancer] +xref: DOID:4934 {source="MONDO:equivalentTo"} +xref: NCIT:C6800 {source="MONDO:equivalentTo", source="DOID:4934"} +xref: UMLS:C1334561 {source="MONDO:equivalentTo", source="DOID:4934"} +is_a: MONDO:0002206 {source="DOID:4934", source="MONDO:Redundant", source="NCIT:C6800"} ! sweat gland cancer +is_a: MONDO:0003686 {source="MONDO:Redundant", source="NCIT:C6800"} ! apocrine sweat gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000382 ! apocrine sweat gland +property_value: exactMatch DOID:4934 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334561 +property_value: exactMatch NCIT:C6800 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003216 +name: ureter adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the ureter" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of the ureter" EXACT [NCIT:C6155] +synonym: "adenocarcinoma of ureter" EXACT [DOID:4938, NCIT:C6155] +synonym: "ureter adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6155] +synonym: "ureteral adenocarcinoma" EXACT [DOID:4938, NCIT:C6155] +xref: DOID:4938 {source="MONDO:equivalentTo"} +xref: NCIT:C6155 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4938"} +xref: UMLS:C1336873 {source="NCIT:C6155", source="MONDO:equivalentTo", source="DOID:4938"} +is_a: MONDO:0004970 {source="DOID:4938", source="MONDO:Redundant", source="NCIT:C6155"} ! adenocarcinoma +is_a: MONDO:0006481 {source="DOID:4938", source="MONDO:Redundant", source="NCIT:C6155"} ! ureter carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:4938 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336873 +property_value: exactMatch NCIT:C6155 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003220 +name: gallbladder carcinoma +def: "A carcinoma that arises from epithelial cells of the gall bladder" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of gallbladder" EXACT [NCIT:C3844] +synonym: "cancer of the gallbladder" EXACT [DOID:4948, NCIT:C3844] +synonym: "carcinoma gallbladder" EXACT [DOID:4948] +synonym: "carcinoma of gall bladder" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of gallbladder" EXACT [NCIT:C3844] +synonym: "carcinoma of the gallbladder" EXACT [NCIT:C3844] +synonym: "gall bladder carcinoma" EXACT [MONDO:patterns/location] +synonym: "Gall bladder carcinoma (adeno)" EXACT [NCIT:C3844] +synonym: "Gall bladder carcinoma (adenocarcinoma)" EXACT [NCIT:C3844] +synonym: "gallbladder cancer" BROAD [NCIT:C3844] +synonym: "gallbladder carcinoma" EXACT [NCIT:C3844] +xref: DOID:4948 {source="MONDO:equivalentTo"} +xref: EFO:1001956 {source="MONDO:equivalentTo"} +xref: NCIT:C3844 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4948"} +xref: SCTID:372140005 {source="MONDO:equivalentTo", source="DOID:4948"} +xref: UMLS:C0235782 {source="MONDO:equivalentTo", source="NCIT:C3844", source="DOID:4948"} +is_a: MONDO:0005411 {source="DOID:4948", source="MONDO:Redundant", source="NCIT:C3844"} ! gallbladder cancer +is_a: MONDO:0006181 {source="EFO:1001956", source="MONDO:Redundant", source="NCIT:C3844"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:4948 +property_value: exactMatch http://identifiers.org/snomedct/372140005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235782 +property_value: exactMatch NCIT:C3844 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003222 +name: central nervous system melanocytic neoplasm +def: "A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion." [NCIT:C5504] +synonym: "central nervous system melanocytic neoplasm" EXACT [MONDO:patterns/location, NCIT:C5504] +synonym: "central nervous system melanocytic neoplasms" EXACT [NCIT:C5504] +synonym: "central nervous system melanocytic tumor" EXACT [NCIT:C5504] +synonym: "central nervous system primary melanocytic lesion" RELATED [DOID:4955] +synonym: "CNS melanocytic neoplasm" EXACT [NCIT:C5504] +synonym: "CNS melanocytic tumor" EXACT [NCIT:C5504] +synonym: "melanocytic neoplasm of central nervous system" EXACT [NCIT:C5504] +synonym: "melanocytic neoplasm of CNS" EXACT [NCIT:C5504] +synonym: "melanocytic neoplasm of the central nervous system" EXACT [NCIT:C5504] +synonym: "melanocytic neoplasm of the CNS" EXACT [NCIT:C5504] +synonym: "melanocytic tumor of central nervous system" EXACT [NCIT:C5504] +synonym: "melanocytic tumor of CNS" EXACT [NCIT:C5504] +synonym: "melanocytic tumor of the central nervous system" EXACT [NCIT:C5504] +synonym: "melanocytic tumor of the CNS" EXACT [DOID:4955, NCIT:C5504] +synonym: "primary melanocytic lesion of meninges" RELATED [DOID:4955] +synonym: "primary melanocytic lesions of the CNS" RELATED [DOID:4955, NCIT:C4661] +xref: DOID:4955 {source="MONDO:equivalentTo"} +xref: EFO:1000493 {source="MONDO:equivalentTo"} +xref: NCIT:C5504 {source="MONDO:equivalentTo", source="DOID:4955", source="MONDO:exact-label-match"} +xref: SCTID:277523004 {source="MONDO:equivalentTo", source="DOID:4955"} +xref: UMLS:C1332887 {source="MONDO:equivalentTo", source="DOID:4955", source="NCIT:C5504"} +is_a: MONDO:0002714 {source="DOID:4955"} ! central nervous system cancer +is_a: MONDO:0021143 {source="MONDO:Redundant", source="NCIT:C5504"} ! melanocytic neoplasm +intersection_of: MONDO:0021143 {source="NCIT:C5504"} ! melanocytic neoplasm +intersection_of: disease_has_location UBERON:0001017 {source="NCIT:C5504"} ! central nervous system +property_value: exactMatch DOID:4955 +property_value: exactMatch http://identifiers.org/snomedct/277523004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332887 +property_value: exactMatch NCIT:C5504 + +[Term] +id: MONDO:0003225 +name: bone marrow disorder +def: "Any disease of the bone marrow." [NCIT:C34433] +synonym: "bone marrow disease" EXACT [MONDO:patterns/location, NCIT:C34433] +synonym: "bone marrow disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "bone marrow disorder" EXACT [DOID:4961, NCIT:C34433] +synonym: "disease of bone marrow" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of bone marrow" EXACT [] +synonym: "disorder of bone marrow" EXACT [MONDO:patterns/location_top] +xref: DOID:4961 {source="MONDO:equivalentTo"} +xref: ICD9:289.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001855 {source="DOID:4961", source="MONDO:equivalentTo"} +xref: NCIT:C34433 {source="DOID:4961", source="MONDO:equivalentTo"} +xref: SCTID:127035006 {source="DOID:4961", source="MONDO:equivalentTo"} +xref: UMLS:C0005956 {source="DOID:4961", source="MONDO:equivalentTo", source="NCIT:C34433"} +is_a: MONDO:0005046 ! immune system disorder +is_a: MONDO:0005172 ! skeletal system disorder +is_a: MONDO:0005570 {source="DOID:4961", source="MESH:D001855", source="MONDO:Entailed", source="MONDO:Redundant"} ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002371 ! bone marrow +relationship: disease_has_location UBERON:0002371 {source="NCIT:C34433"} ! bone marrow +property_value: exactMatch DOID:4961 +property_value: exactMatch http://identifiers.org/mesh/D001855 +property_value: exactMatch http://identifiers.org/snomedct/127035006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005956 +property_value: exactMatch NCIT:C34433 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003232 +name: alcoholic pancreatitis +def: "Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics." [MESH:D019512] +synonym: "alcoholic pancreatitis" EXACT [MESH:D019512] +xref: DOID:4988 {source="MONDO:equivalentTo"} +xref: EFO:1002013 {source="MONDO:equivalentTo"} +xref: MESH:D019512 {source="MONDO:equivalentTo", source="DOID:4988"} +xref: SCTID:445507008 {source="MONDO:equivalentTo", source="DOID:4988"} +xref: UMLS:C0376670 {source="MONDO:equivalentTo", source="DOID:4988"} +is_a: MONDO:0004982 {source="DOID:4988", source="EFO:1002013", source="MESH:D019512", source="MONDO:Redundant"} ! pancreatitis +is_a: MONDO:0021699 {source="MESH:D019512"} ! alcohol-induced disorders +intersection_of: MONDO:0004982 ! pancreatitis +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:4988 +property_value: exactMatch http://identifiers.org/mesh/D019512 +property_value: exactMatch http://identifiers.org/snomedct/445507008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376670 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/realized_in_response_to_environmental_exposure.yaml + +[Term] +id: MONDO:0003234 +name: optic nerve astrocytoma +def: "A astrocytoma (excluding glioblastoma) that involves the cranial nerve II." [MONDO:patterns/location] +synonym: "astrocytic tumor of optic nerve" EXACT [DOID:4991, NCIT:C6769] +synonym: "astrocytoma (excluding glioblastoma) of cranial nerve II" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of optic nerve" EXACT [NCIT:C6769] +synonym: "astrocytoma of the optic nerve" EXACT [NCIT:C6769] +synonym: "cranial nerve II astrocytoma (excluding glioblastoma)" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "optic nerve astrocytoma" EXACT [NCIT:C6769] +synonym: "optic tract astrocytoma" RELATED [DOID:4991, MONDO:patterns/location] +synonym: "optic tract astrocytoma (excluding glioblastoma)" RELATED [MONDO:patterns/location] +xref: DOID:4991 {source="MONDO:equivalentTo"} +xref: NCIT:C6769 {source="DOID:4991", source="MONDO:equivalentTo"} +xref: NCIT:C7533 {source="DOID:4991", source="MONDO:directSiblingOf"} +xref: UMLS:C1335114 {source="DOID:4991", source="MONDO:equivalentTo", source="NCIT:C6769"} +xref: UMLS:C1336971 {source="DOID:4991", source="MONDO:directSiblingOf"} +is_a: MONDO:0002433 ! malignant cranial nerve neoplasm +is_a: MONDO:0003235 {source="DOID:4991", source="MONDO:Redundant", source="NCIT:C6769"} ! optic nerve glioma +is_a: MONDO:0024649 ! optic tract astrocytoma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0000941 ! cranial nerve II +property_value: exactMatch DOID:4991 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335114 +property_value: exactMatch NCIT:C6769 + +[Term] +id: MONDO:0003235 +name: optic nerve glioma +def: "A glioma that affects the optic nerve. This condition can be seen in association with neurofibromatosis 1. It is most commonly seen in the pediatric age group." [NCIT:C4537] +synonym: "cranial nerve II glioma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "glioma of cranial nerve II" EXACT [MONDO:design_pattern] +synonym: "glioma of optic nerve" EXACT [NCIT:C4537] +synonym: "glioma of the optic nerve" EXACT [DOID:4992, NCIT:C4537] +synonym: "optic nerve glioma" EXACT [NCIT:C4537] +xref: DOID:4992 {source="MONDO:equivalentTo"} +xref: ICD9:237.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D020339 {source="DOID:4992", source="MONDO:equivalentTo"} +xref: NCIT:C4537 {source="DOID:4992", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:254976006 {source="DOID:4992", source="MONDO:equivalentTo"} +xref: UMLS:C0346326 {source="DOID:4992", source="MONDO:equivalentTo", source="NCIT:C4537"} +is_a: MONDO:0002640 {source="DOID:4992", source="MESH:D020339", source="MONDO:Redundant", source="NCIT:C4537"} ! optic nerve neoplasm +is_a: MONDO:0016167 {source="NCIT:C4537"} ! optic pathway glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: disease_has_location UBERON:0000941 ! cranial nerve II +property_value: exactMatch DOID:4992 +property_value: exactMatch http://identifiers.org/mesh/D020339 +property_value: exactMatch http://identifiers.org/snomedct/254976006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346326 +property_value: exactMatch NCIT:C4537 + +[Term] +id: MONDO:0003240 +name: thyroid gland disorder +def: "A disease involving the thyroid gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of thyroid gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of thyroid gland" EXACT [] +synonym: "disorder of thyroid gland" EXACT [MONDO:patterns/location_top] +synonym: "thyroid disease" EXACT [MONDO:0006494] +synonym: "thyroid gland disease" EXACT [MONDO:patterns/location, NCIT:C26893] +synonym: "thyroid gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "thyroid gland diseases" EXACT [NCIT:C26893] +synonym: "thyroid gland disorder" EXACT [NCIT:C26893] +synonym: "thyroid gland disorders" EXACT [NCIT:C26893] +xref: DOID:50 {source="MONDO:equivalentTo"} +xref: EFO:1000627 {source="MONDO:equivalentTo"} +xref: ICD10CM:E00-E07 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="DOID:50", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:240-246.99 {source="DOID:50"} +xref: ICD9:246.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:246.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:50"} +xref: MESH:D013959 {source="MONDO:equivalentTo", source="DOID:50"} +xref: NCIT:C26893 {source="MONDO:equivalentTo", source="DOID:50"} +xref: SCTID:14304000 {source="MONDO:equivalentTo", source="DOID:50"} +xref: UMLS:C0040128 {source="NCIT:C26893", source="MONDO:equivalentTo", source="DOID:50"} +xref: Wikipedia:Thyroid_disease {source="EFO:1000627"} +is_a: MONDO:0005151 {source="DOID:50", source="MESH:D013959", source="MONDO:Redundant"} ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +relationship: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch DOID:50 +property_value: exactMatch http://identifiers.org/mesh/D013959 +property_value: exactMatch http://identifiers.org/snomedct/14304000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040128 +property_value: exactMatch https://icd.codes/icd10cm/E00-E07 +property_value: exactMatch NCIT:C26893 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003249 +name: pineal gland cancer +def: "Abnormal malignant growth of the cells that comprise the pineal parenchyma." [NCIT:C3573] +synonym: "cancer of pineal body" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pineal body" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pineal gland" EXACT [NCIT:C3573] +synonym: "malignant neoplasm of the pineal gland" EXACT [NCIT:C3573] +synonym: "malignant pineal area neoplasm" EXACT [NCIT:C3573] +synonym: "malignant pineal area tumor" EXACT [NCIT:C3573] +synonym: "malignant pineal body neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant pineal gland neoplasm" EXACT [NCIT:C3573] +synonym: "malignant pineal gland tumor" EXACT [NCIT:C3573] +synonym: "malignant pineal region neoplasm" EXACT [NCIT:C3573] +synonym: "malignant pineal region tumor" EXACT [DOID:5032, NCIT:C3573] +synonym: "malignant tumor of pineal gland" EXACT [DOID:5032, NCIT:C3573] +synonym: "malignant tumor of the pineal gland" EXACT [NCIT:C3573] +synonym: "neoplasm of the pineal region" BROAD [DOID:5032] +synonym: "pineal body cancer" EXACT [MONDO:patterns/location] +synonym: "pinealoma" RELATED [DOID:5032] +synonym: "pineocytic tumor" BROAD [DOID:5032] +synonym: "tumor of the pineal region" BROAD [DOID:5032] +xref: DOID:5032 {source="MONDO:equivalentTo"} +xref: ICD9:194.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5032"} +xref: NCIT:C3573 {source="MONDO:equivalentTo", source="DOID:5032"} +xref: NCIT:C6965 {source="DOID:5032", source="MONDO:directSiblingOf"} +xref: SCTID:363483004 {source="MONDO:equivalentTo", source="DOID:5032"} +xref: UMLS:C0031941 {source="DOID:5032", source="MONDO:directSiblingOf"} +is_a: MONDO:0003766 ! thalamic cancer +is_a: MONDO:0021069 ! malignant endocrine neoplasm +is_a: MONDO:0021232 {source="MONDO:Redundant", source="NCIT:C3573"} ! pineal body neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001905 ! pineal body +property_value: exactMatch DOID:5032 +property_value: exactMatch http://identifiers.org/snomedct/363483004 +property_value: exactMatch NCIT:C3573 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003257 +name: posterior pituitary gland neoplasm +def: "A low-grade neoplasm that arises from the neurohypophysis. It includes the granular cell tumor of the neurohypophysis and pituicytoma." [NCIT:C7157] +synonym: "neoplasm of neurohypophysis" EXACT [MONDO:patterns/neoplasm] +synonym: "Neurohypophysis neoplasm" EXACT [NCIT:C7157] +synonym: "neurohypophysis neoplasm" EXACT [] +synonym: "neurohypophysis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "Neurohypophysis tumor" EXACT [NCIT:C7157] +synonym: "neurohypophysis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "PITUICYTOMA, benign" EXACT [NCIT:C7157] +synonym: "posterior pituitary gland neoplasm" EXACT [NCIT:C7157] +synonym: "posterior pituitary gland tumor" EXACT [NCIT:C7157] +synonym: "posterior pituitary neoplasm" EXACT [NCIT:C7157] +synonym: "posterior pituitary tumor" EXACT [DOID:5048, NCIT:C7157] +synonym: "tumor of neurohypophysis" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5048 {source="MONDO:equivalentTo"} +xref: NCIT:C7157 {source="DOID:5048", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334957 {source="DOID:5048", source="NCIT:C7157", source="MONDO:equivalentTo"} +is_a: MONDO:0017611 {source="MONDO:Redundant", source="NCIT:C7157"} ! pituitary tumor +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002198 ! neurohypophysis +relationship: disease_has_location UBERON:0002198 {source="NCIT:C7157"} ! neurohypophysis +property_value: exactMatch DOID:5048 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334957 +property_value: exactMatch NCIT:C7157 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003263 +name: childhood cerebellar neoplasm +def: "A neoplasm that affects the cerebellum and occurs during childhood." [NCIT:C5970] +synonym: "childhood cerebellar neoplasm" EXACT [NCIT:C5970] +synonym: "childhood cerebellar neoplasms" EXACT [NCIT:C5970] +synonym: "childhood cerebellar tumor" EXACT [NCIT:C5970] +synonym: "childhood cerebellar tumors" EXACT [NCIT:C5970] +synonym: "childhood neoplasm of cerebellum" EXACT [NCIT:C5970] +synonym: "childhood neoplasm of the cerebellum" EXACT [NCIT:C5970] +synonym: "childhood tumor of cerebellum" EXACT [NCIT:C5970] +synonym: "childhood tumor of the cerebellum" EXACT [NCIT:C5970] +synonym: "pediatric cerebellar neoplasm" EXACT [NCIT:C5970] +synonym: "pediatric cerebellar tumor" EXACT [NCIT:C5970] +synonym: "pediatric neoplasm of cerebellum" EXACT [NCIT:C5970] +synonym: "pediatric neoplasm of the cerebellum" EXACT [NCIT:C5970] +synonym: "pediatric tumor of cerebellum" EXACT [DOID:5059, NCIT:C5970] +synonym: "pediatric tumor of the cerebellum" EXACT [NCIT:C5970] +xref: DOID:5059 {source="MONDO:equivalentTo"} +xref: NCIT:C5970 {source="DOID:5059", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332959 {source="DOID:5059", source="NCIT:C5970", source="MONDO:equivalentTo"} +is_a: MONDO:0002913 {source="DOID:5059", source="MONDO:Redundant", source="NCIT:C5970"} ! cerebellar neoplasm +is_a: MONDO:0002915 {source="MONDO:Redundant", source="NCIT:C5970"} ! childhood infratentorial neoplasm +intersection_of: MONDO:0002913 {source="NCIT:C5970"} ! cerebellar neoplasm +intersection_of: MONDO:0002915 {source="NCIT:C5970"} ! childhood infratentorial neoplasm +property_value: exactMatch DOID:5059 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332959 +property_value: exactMatch NCIT:C5970 + +[Term] +id: MONDO:0003266 +name: ependymal tumor +def: "A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)" [NCIT:C6770] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:301"} +synonym: "ependymal neoplasm" EXACT [DOID:5074, NCIT:C6770] +synonym: "ependymal tumor" EXACT [MONDO:0017605, NCIT:C6770] +synonym: "ependymal tumors" EXACT [DOID:5074] +synonym: "ependymomal tumor" RELATED [ONCOTREE:EPMT] +xref: EFO:1000027 {source="MONDO:equivalentTo"} +xref: ICD10CM:C71.7 {source="Orphanet:301", source="Orphanet:301/ntbt"} +xref: NCIT:C6770 {source="MONDO:equivalentTo"} +xref: OMIM:137800 {source="Orphanet:301", source="MONDO:relatedTo", source="Orphanet:301/ntbt"} +xref: ONCOTREE:EPMT {source="MONDO:equivalentTo"} +xref: Orphanet:301 {source="MONDO:equivalentTo"} +xref: UMLS:C1333407 {source="NCIT:C6770", source="MONDO:equivalentTo"} +xref: UMLS:CN203416 {source="MONDO:equivalentTo"} +is_a: MONDO:0021042 {source="NCIT:C6770"} ! glioma +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure UBERON:0004670 ! ependyma +relationship: disease_arises_from_structure UBERON:0004670 ! ependyma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333407 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203416 +property_value: exactMatch NCIT:C6770 +property_value: exactMatch Orphanet:301 +property_value: narrowMatch https://icd.codes/icd10cm/C71.7 + +[Term] +id: MONDO:0003273 +name: sternum cancer +def: "A malignant neoplasm involving the sternum" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of sternum" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sternum" EXACT [MONDO:patterns/cancer, NCIT:C8408] +synonym: "malignant neoplasm of the sternum" EXACT [NCIT:C8408] +synonym: "malignant sternal neoplasm" EXACT [DOID:5090] +synonym: "malignant sternal tumor" EXACT [DOID:5090, NCIT:C8408] +synonym: "malignant sternum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of sternum" EXACT [NCIT:C8408] +synonym: "malignant tumor of the sternum" EXACT [NCIT:C8408] +synonym: "neoplasm of sternum" BROAD [DOID:5090] +synonym: "sternum cancer" EXACT [MONDO:patterns/location] +xref: DOID:5090 {source="MONDO:equivalentTo"} +xref: NCIT:C8408 {source="DOID:5090", source="MONDO:equivalentTo"} +xref: UMLS:C1382025 {source="DOID:5090", source="MONDO:equivalentTo"} +is_a: MONDO:0002129 {source="DOID:5090", source="MONDO:Entailed", source="MONDO:Redundant"} ! bone cancer +is_a: MONDO:0003274 ! thoracic cancer +is_a: MONDO:0021578 {source="MONDO:Redundant", source="NCIT:C8408"} ! sternal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000975 ! sternum +property_value: exactMatch DOID:5090 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1382025 +property_value: exactMatch NCIT:C8408 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003274 +name: thoracic cancer +def: "A primary or metastatic malignant neoplasm affecting the tissues of the thorax." [NCIT:C3576] +synonym: "cancer of thoracic segment of trunk" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the thorax" EXACT [NCIT:C3576] +synonym: "malignant neoplasm of thoracic segment of trunk" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of thorax" EXACT [NCIT:C3576] +synonym: "malignant thoracic neoplasm" EXACT [NCIT:C3576] +synonym: "malignant thoracic segment of trunk neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant thoracic tumor" EXACT [NCIT:C3576] +synonym: "malignant tumor of the thorax" EXACT [NCIT:C3576] +synonym: "malignant tumor of thorax" EXACT [NCIT:C3576] +synonym: "thoracic segment of trunk cancer" EXACT [MONDO:patterns/location] +synonym: "thoracic tumor" BROAD [DOID:5093, NCIT:C3406] +synonym: "thorax cancer" EXACT [DOID:5093] +synonym: "thorax neoplasm" BROAD [DOID:5093] +synonym: "tumor of thorax" BROAD [DOID:5093] +xref: DOID:5093 {source="MONDO:equivalentTo"} +xref: ICD9:195.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5093"} +xref: NCIT:C3576 {source="MONDO:equivalentTo", source="DOID:5093"} +xref: SCTID:188361007 {source="MONDO:equivalentTo", source="DOID:5093"} +xref: UMLS:C0153661 {source="MONDO:equivalentTo", source="NCIT:C3576", source="DOID:5093"} +is_a: MONDO:0004992 {source="DOID:5093", source="DOID:5093/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C3576"} ! neoplasm of thorax +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000915 ! thoracic segment of trunk +property_value: exactMatch DOID:5093 +property_value: exactMatch http://identifiers.org/snomedct/188361007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153661 +property_value: exactMatch NCIT:C3576 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003275 +name: middle ear cancer +def: "A malignant neoplasm involving the middle ear" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of middle ear" EXACT [MONDO:patterns/cancer] +synonym: "malignant middle ear neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant middle Ear tumor" EXACT [NCIT:C4765] +synonym: "malignant neoplasm of middle ear" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the middle Ear" EXACT [NCIT:C4765] +synonym: "malignant tumor of middle Ear" EXACT [NCIT:C4765] +synonym: "malignant tumor of the middle Ear" EXACT [NCIT:C4765] +synonym: "middle ear cancer" EXACT [MONDO:patterns/location] +synonym: "tumor of the middle ear" BROAD [DOID:5099, NCIT:C4412] +xref: DOID:5099 {source="MONDO:equivalentTo"} +xref: NCIT:C4765 {source="MONDO:equivalentTo"} +xref: SCTID:363359008 {source="MONDO:equivalentTo"} +is_a: MONDO:0003277 {source="MONDO:Redundant", source="NCIT:C4765"} ! malignant ear neoplasm +is_a: MONDO:0004532 ! auditory system cancer +is_a: MONDO:0021366 {source="MONDO:Redundant", source="NCIT:C4765"} ! neoplasm of middle ear +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch DOID:5099 +property_value: exactMatch http://identifiers.org/snomedct/363359008 +property_value: exactMatch NCIT:C4765 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003276 +name: middle ear disorder +def: "A disease involving the middle ear." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of middle ear" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of middle ear" EXACT [] +synonym: "disorder of middle ear" EXACT [MONDO:patterns/location_top] +synonym: "middle ear disease" EXACT [MONDO:patterns/location] +synonym: "middle ear disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "middle Ear disorder" EXACT [NCIT:C27065] +xref: DOID:5100 {source="MONDO:equivalentTo"} +xref: ICD10CM:H65-H75 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: NCIT:C27065 {source="MONDO:equivalentTo", source="DOID:5100"} +xref: SCTID:68996008 {source="MONDO:equivalentTo", source="DOID:5100"} +xref: UMLS:C0271428 {source="NCIT:C27065", source="MONDO:equivalentTo", source="DOID:5100"} +is_a: MONDO:0002409 {source="DOID:5100"} ! auditory system disorder +is_a: MONDO:0021205 {source="MONDO:Redundant", source="NCIT:C27065"} ! disorder of ear +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001756 ! middle ear +relationship: disease_has_location UBERON:0001756 {source="NCIT:C27065"} ! middle ear +property_value: exactMatch DOID:5100 +property_value: exactMatch http://identifiers.org/snomedct/68996008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271428 +property_value: exactMatch https://icd.codes/icd10cm/H65-H75 +property_value: exactMatch NCIT:C27065 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003277 +name: malignant ear neoplasm +def: "A malignant neoplasm that affects the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear." [NCIT:P378] +synonym: "auricular cancer" RELATED [DOID:5101] +synonym: "cancer of ear" EXACT [MONDO:patterns/cancer] +synonym: "ear cancer" EXACT [MONDO:patterns/location] +synonym: "malignant Ear neoplasm" EXACT [NCIT:C9337] +synonym: "malignant ear neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant Ear tumor" EXACT [NCIT:C9337] +synonym: "malignant neoplasm of Ear" EXACT [NCIT:C9337] +synonym: "malignant neoplasm of ear" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the Ear" EXACT [NCIT:C9337] +synonym: "malignant tumor of Ear" EXACT [NCIT:C9337] +synonym: "malignant tumor of ear" EXACT [DOID:5101, NCIT:C9337] +synonym: "malignant tumor of the Ear" EXACT [NCIT:C9337] +xref: DOID:5101 {source="MONDO:equivalentTo"} +xref: MESH:D004428 {source="DOID:5101", source="MONDO:equivalentTo"} +xref: NCIT:C9337 {source="MONDO:equivalentTo"} +xref: SCTID:443648003 {source="MONDO:equivalentTo"} +xref: UMLS:C0751094 {source="DOID:5101", source="MONDO:equivalentTo", source="NCIT:C9337"} +is_a: MONDO:0000649 ! sensory system cancer +is_a: MONDO:0005627 {source="MONDO:Redundant", source="NCIT:C9337"} ! head and neck cancer +is_a: MONDO:0021233 {source="MONDO:Redundant", source="NCIT:C9337"} ! ear neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001690 ! ear +property_value: exactMatch DOID:5101 +property_value: exactMatch http://identifiers.org/mesh/D004428 +property_value: exactMatch http://identifiers.org/snomedct/443648003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751094 +property_value: exactMatch NCIT:C9337 +property_value: excluded_subClassOf MONDO:0004532 {source="DOID:5101"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003278 +name: inner ear cancer +def: "A malignant neoplasm involving the internal ear." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of internal ear" EXACT [MONDO:patterns/cancer] +synonym: "internal ear cancer" EXACT [MONDO:patterns/location] +synonym: "malignant internal ear neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of internal ear" EXACT [MONDO:patterns/cancer] +xref: DOID:5102 {source="MONDO:equivalentTo"} +xref: NCIT:C39784 {source="DOID:5102", source="MONDO:directSiblingOf"} +xref: UMLS:C1512779 {source="DOID:5102", source="MONDO:directSiblingOf"} +is_a: MONDO:0003277 ! malignant ear neoplasm +is_a: MONDO:0004532 ! auditory system cancer +is_a: MONDO:0024320 ! inner ear neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001846 ! internal ear +property_value: exactMatch DOID:5102 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003283 +name: epididymal neoplasm +def: "A benign or malignant neoplasm that affects the epididymis. Representative examples include epididymal adenomatoid tumor and epididymal adenocarcinoma." [NCIT:C39958] +synonym: "epididymal neoplasm" EXACT [NCIT:C39958] +synonym: "epididymis neoplasm" EXACT [] +synonym: "epididymis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "epididymis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of epididymis" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of epididymus" EXACT [] +synonym: "tumor of epididymis" EXACT [MONDO:patterns/neoplasm] +xref: DOID:512 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C39958 {source="DOID:512", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126902008 {source="DOID:512", source="MONDO:equivalentTo"} +xref: UMLS:C0346239 {source="DOID:512", source="MONDO:equivalentTo", source="NCIT:C39958"} +is_a: MONDO:0024582 ! male reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001301 ! epididymis +relationship: disease_has_location UBERON:0001301 {source="NCIT:C39958"} ! epididymis +property_value: exactMatch DOID:512 +property_value: exactMatch http://identifiers.org/snomedct/126902008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346239 +property_value: exactMatch NCIT:C39958 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003311 +name: endometrial stromal tumor +def: "Neoplasms of the endometrial stroma that sometimes involve the myometrium. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (sarcoma, endometrial stromal)." [MESH:D036821] +synonym: "endometrial stroma neoplasm" EXACT [] +synonym: "endometrial stroma tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "endometrial stromal neoplasm" EXACT [DOID:5166, NCIT:C8384] +synonym: "endometrial stromal tumor" EXACT [] +synonym: "endometrial stromal tumor (morphologic abnormality)" EXACT [DOID:5166] +synonym: "neoplasm of endometrial stroma" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of endometrial stroma" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5166 {source="MONDO:equivalentTo"} +xref: EFO:1000920 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D036821 {source="MONDO:equivalentTo", source="DOID:5166"} +xref: SCTID:446887007 {source="MONDO:equivalentTo", source="DOID:5166"} +xref: UMLS:C0334695 {source="MONDO:equivalentTo", source="DOID:5166"} +is_a: MONDO:0021251 {source="MONDO:Redundant"} ! endometrium neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002337 ! endometrial stroma +relationship: disease_has_location UBERON:0002337 ! endometrial stroma +property_value: exactMatch DOID:5166 +property_value: exactMatch http://identifiers.org/mesh/D036821 +property_value: exactMatch http://identifiers.org/snomedct/446887007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334695 +property_value: excluded_subClassOf MONDO:0011962 {source="DOID:5166"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003319 +name: scrotum neoplasm +def: "A benign or malignant neoplasm that affects the scrotum." [NCIT:C4380] +synonym: "malignant scrotal neoplasm" NARROW [DOID:518] +synonym: "malignant tumor of scrotum" NARROW [DOID:518] +synonym: "malignant tumour of scrotum" NARROW [DOID:518] +synonym: "neoplasm of scrotum" EXACT [MONDO:patterns/neoplasm, NCIT:C4380] +synonym: "neoplasm of the scrotum" EXACT [NCIT:C4380] +synonym: "scrotal Ca" EXACT [DOID:518] +synonym: "scrotal neoplasm" EXACT [NCIT:C4380] +synonym: "scrotal tumor" EXACT [NCIT:C4380] +synonym: "scrotum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "scrotum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of scrotum" EXACT [MONDO:patterns/neoplasm, NCIT:C4380] +synonym: "tumor of the scrotum" EXACT [NCIT:C4380] +xref: DOID:518 {source="MONDO:equivalentTo"} +xref: ICD9:187.7 {source="DOID:518"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4380 {source="DOID:518", source="MONDO:equivalentTo"} +xref: SCTID:126905005 {source="DOID:518", source="MONDO:equivalentTo"} +xref: UMLS:C0341790 {source="DOID:518", source="MONDO:equivalentTo", source="NCIT:C4380"} +is_a: MONDO:0024582 ! male reproductive system neoplasm +is_a: MONDO:0045003 ! scrotal disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch DOID:518 +property_value: exactMatch http://identifiers.org/snomedct/126905005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341790 +property_value: exactMatch NCIT:C4380 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003342 +name: benign perivascular tumor +def: "A benign mesenchymal neoplasm arising from the perivascular cells of the connective and soft tissues. It is characterized by the presence of pericytes that grow in a circumferential pattern around vessels." [NCIT:P378] +synonym: "benign Pericytic neoplasm" EXACT [NCIT:C6529] +synonym: "benign pericytic neoplasm" EXACT [] +synonym: "benign Pericytic tumor" EXACT [NCIT:C6529] +synonym: "benign perivascular neoplasm" EXACT [NCIT:C6529] +synonym: "benign perivascular tumor" EXACT [NCIT:C6529] +synonym: "pericytic neoplasm, benign" EXACT [MONDO:patterns/benign] +xref: DOID:5238 {source="MONDO:equivalentTo"} +xref: NCIT:C6529 {source="DOID:5238", source="MONDO:equivalentTo"} +xref: UMLS:C1332532 {source="DOID:5238", source="MONDO:equivalentTo", source="NCIT:C6529"} +is_a: MONDO:0002604 {source="MONDO:Redundant", source="NCIT:C6529"} ! pericytic neoplasm +is_a: MONDO:0005165 ! benign neoplasm +intersection_of: MONDO:0002604 ! pericytic neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:5238 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332532 +property_value: exactMatch NCIT:C6529 +property_value: excluded_subClassOf MONDO:0000629 {source="DOID:5238"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0003346 +name: central nervous system vasculitis +def: "Vasculitis affecting the blood vessels of the brain and/or spinal cord." [NCIT:P378] +synonym: "central nervous system vasculitis" EXACT [MONDO:patterns/location] +synonym: "vasculitis of central nervous system" EXACT [MONDO:design_pattern] +xref: DOID:525 {source="MONDO:equivalentTo"} +xref: MESH:D020293 {source="DOID:525", source="MONDO:equivalentTo"} +xref: NCIT:C84622 {source="DOID:525", source="MONDO:equivalentTo"} +xref: UMLS:C0751878 {source="NCIT:C84622", source="DOID:525", source="MONDO:equivalentTo"} +is_a: MONDO:0002602 {source="DOID:525", source="MESH:D020293/inferred", source="MONDO:Entailed", source="MONDO:Redundant"} ! central nervous system disorder +is_a: MONDO:0018882 {source="DOID:525", source="MESH:D020293", source="MONDO:Redundant", source="NCIT:C84622"} ! vasculitis +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:525 +property_value: exactMatch http://identifiers.org/mesh/D020293 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751878 +property_value: exactMatch NCIT:C84622 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0003363 +name: malignant dermis tumor +def: "A malignant neoplasm involving the dermis." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of dermis" EXACT [MONDO:patterns/cancer] +synonym: "dermis cancer" EXACT [MONDO:patterns/location] +synonym: "malignant dermal neoplasm" EXACT [NCIT:C4574] +synonym: "malignant dermis neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4574] +synonym: "malignant dermis tumor" EXACT [NCIT:C4574] +synonym: "malignant neoplasm of dermis" EXACT [DOID:5274, MONDO:patterns/cancer, NCIT:C4574] +synonym: "malignant neoplasm of the dermis" EXACT [NCIT:C4574] +synonym: "malignant tumor of dermis" EXACT [NCIT:C4574] +synonym: "malignant tumor of the dermis" EXACT [NCIT:C4574] +xref: DOID:5274 {source="MONDO:equivalentTo"} +xref: NCIT:C4574 {source="MONDO:equivalentTo", source="DOID:5274"} +xref: SCTID:255096006 {source="MONDO:equivalentTo", source="DOID:5274"} +xref: UMLS:C0346811 {source="MONDO:equivalentTo", source="NCIT:C4574", source="DOID:5274"} +is_a: MONDO:0002300 {source="MONDO:Redundant", source="NCIT:C4574"} ! dermis tumor +is_a: MONDO:0002898 {source="DOID:5274", source="MONDO:Redundant", source="NCIT:C4574"} ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002067 ! dermis +property_value: exactMatch DOID:5274 +property_value: exactMatch http://identifiers.org/snomedct/255096006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346811 +property_value: exactMatch NCIT:C4574 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003381 +name: pituitary gland disorder +def: "A disease involving the pituitary gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of pituitary gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pituitary gland" EXACT [] +synonym: "disorder of pituitary gland" EXACT [MONDO:patterns/location_top] +synonym: "pituitary disease" EXACT [DOID:53] +synonym: "pituitary gland disease" EXACT [MONDO:patterns/location, NCIT:C26854] +synonym: "pituitary gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "pituitary gland disorder" EXACT [NCIT:C26854] +xref: DOID:53 {source="MONDO:equivalentTo"} +xref: ICD9:253.1 {source="DOID:53"} +xref: ICD9:253.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:253.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010900 {source="MONDO:equivalentTo"} +xref: NCIT:C26854 {source="MONDO:equivalentTo"} +xref: SCTID:399244003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 {source="MESH:D010900/inferred", source="MONDO:Redundant"} ! brain disorder +is_a: MONDO:0100070 ! neuroendocrine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +relationship: disease_has_location UBERON:0000007 ! pituitary gland +property_value: exactMatch DOID:53 +property_value: exactMatch http://identifiers.org/mesh/D010900 +property_value: exactMatch http://identifiers.org/snomedct/399244003 +property_value: exactMatch NCIT:C26854 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003382 +name: eyelid disorder +def: "A disease involving the eyelid." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of eyelid" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of eyelid" EXACT [] +synonym: "disorder of eyelid" EXACT [MONDO:patterns/location_top] +synonym: "eyelid disease" EXACT [MONDO:patterns/location] +synonym: "eyelid disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "eyelid disorder" EXACT [NCIT:C26768] +xref: DOID:530 {source="MONDO:equivalentTo"} +xref: ICD10CM:H00 {source="MONDO:equivalentTo"} +xref: ICD9:374.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:374.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:530"} +xref: MESH:D005141 {source="MONDO:equivalentTo", source="DOID:530"} +xref: NCIT:C26768 {source="MONDO:equivalentTo", source="DOID:530"} +xref: SCTID:60113004 {source="MONDO:equivalentTo", source="DOID:530"} +is_a: MONDO:0000462 {source="DOID:530", source="ICD10CM:H00"} ! eye adnexa disorder +is_a: MONDO:0005328 {source="MESH:D005141", source="MONDO:Entailed", source="NCIT:C26768"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001711 ! eyelid +relationship: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch DOID:530 +property_value: exactMatch http://identifiers.org/mesh/D005141 +property_value: exactMatch http://identifiers.org/snomedct/60113004 +property_value: exactMatch https://icd.codes/icd10cm/H00 +property_value: exactMatch NCIT:C26768 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003392 +name: fallopian tube germ cell tumor +def: "A rare germ cell tumor that affects the fallopian tube. The vast majority of cases are teratomas." [NCIT:C40130] +synonym: "fallopian tube germ cell cancer" RELATED [DOID:5324] +synonym: "fallopian tube germ cell neoplasm" EXACT [DOID:5324, NCIT:C40130] +synonym: "fallopian tube germ cell tumor" EXACT [MONDO:patterns/location, NCIT:C40130] +xref: DOID:5324 {source="MONDO:equivalentTo"} +xref: NCIT:C40130 {source="DOID:5324", source="MONDO:equivalentTo"} +xref: UMLS:C1517114 {source="DOID:5324", source="MONDO:equivalentTo", source="NCIT:C40130"} +is_a: MONDO:0005040 {source="DOID:5324", source="MONDO:Redundant", source="NCIT:C40130"} ! germ cell tumor +is_a: MONDO:0021092 {source="MONDO:Redundant", source="NCIT:C40130"} ! fallopian tube neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:5324 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1517114 +property_value: exactMatch NCIT:C40130 +property_value: excluded_subClassOf MONDO:0002158 {source="DOID:5324"} + +[Term] +id: MONDO:0003393 +name: thymus gland disorder +def: "A non-neoplastic or neoplastic disorder that affects the thymus. Representative examples include thymic hyperplasia, thymoma, and thymic carcinoma." [NCIT:C26962] +synonym: "disease of thymus" EXACT [MONDO:patterns/location_top] +synonym: "disease of thymus gland" EXACT [DOID:533] +synonym: "disease or disorder of thymus" EXACT [] +synonym: "disorder of thymus" EXACT [MONDO:patterns/location_top] +synonym: "disorder of thymus gland" EXACT [] +synonym: "thymus disease" EXACT [MONDO:patterns/location] +synonym: "thymus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "Thymus disorder" EXACT [NCIT:C26962] +synonym: "thymus disorder" RELATED [] +xref: DOID:533 {source="MONDO:equivalentTo"} +xref: ICD9:254 {source="DOID:533"} +xref: ICD9:254.9 {source="DOID:533"} +xref: NCIT:C26962 {source="DOID:533", source="MONDO:equivalentTo"} +xref: SCTID:20673009 {source="DOID:533", source="MONDO:equivalentTo"} +xref: UMLS:C0154199 {source="DOID:533", source="MONDO:equivalentTo", source="NCIT:C26962"} +is_a: MONDO:0005046 ! immune system disorder +is_a: MONDO:0005151 ! endocrine system disorder +is_a: MONDO:0005570 ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002370 ! thymus +relationship: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch DOID:533 +property_value: exactMatch http://identifiers.org/snomedct/20673009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154199 +property_value: exactMatch NCIT:C26962 +property_value: excluded_subClassOf MONDO:0005833 {source="DOID:533"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003394 +name: dental pulp disorder +def: "A disease involving the dental pulp." [https://orcid.org/0000-0002-6601-2165] +synonym: "dental pulp disease" EXACT [MONDO:patterns/location] +synonym: "dental pulp disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "dental pulp disorder" EXACT [DOID:5330, NCIT:C34530] +synonym: "disease of dental pulp" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of dental pulp" EXACT [] +synonym: "disorder of dental pulp" EXACT [MONDO:patterns/location_top] +synonym: "disorder of pulp of tooth" EXACT [DOID:5330] +synonym: "pulp disorder" EXACT [DOID:5330] +xref: DOID:5330 {source="MONDO:equivalentTo"} +xref: ICD9:522.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003788 {source="MONDO:equivalentTo", source="DOID:5330"} +xref: NCIT:C34530 {source="MONDO:equivalentTo", source="DOID:5330"} +xref: SCTID:57203004 {source="MONDO:equivalentTo", source="DOID:5330"} +xref: UMLS:C0011405 {source="MONDO:equivalentTo", source="NCIT:C34530", source="DOID:5330"} +is_a: MONDO:0006999 {source="DOID:5330", source="MESH:D003788", source="MONDO:Redundant", source="NCIT:C34530"} ! tooth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001754 ! dental pulp +relationship: disease_has_location UBERON:0001754 ! dental pulp +property_value: exactMatch DOID:5330 +property_value: exactMatch http://identifiers.org/mesh/D003788 +property_value: exactMatch http://identifiers.org/snomedct/57203004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011405 +property_value: exactMatch NCIT:C34530 +property_value: excluded_subClassOf MONDO:0003900 {source="DOID:5330", source="MONDO:Redundant"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003395 +name: testicular granulosa cell tumor +def: "A rare sex cord-stromal tumor that arises from the testis. It is characterized by the presence of granulosa-like cells and Call-Exner bodies. There are two variants described, the adult and the juvenile." [NCIT:C6357] +synonym: "granulosa cell neoplasm of testis" RELATED [NCIT:C6357] +synonym: "granulosa cell neoplasm of the testis" RELATED [NCIT:C6357] +synonym: "granulosa cell tumor of testis" EXACT [DOID:5331, NCIT:C6357] +synonym: "granulosa cell tumor of the testis" RELATED [NCIT:C6357] +synonym: "testicular granulosa cell neoplasm" RELATED [NCIT:C6357] +synonym: "testicular granulosa cell tumor" EXACT [NCIT:C6357] +synonym: "testis granulosa cell tumor" EXACT [MONDO:patterns/location] +xref: DOID:5331 {source="MONDO:equivalentTo"} +xref: EFO:1000567 {source="MONDO:equivalentTo"} +xref: NCIT:C6357 {source="MONDO:equivalentTo", source="NCIT:C6357", source="DOID:5331"} +xref: UMLS:C1336709 {source="MONDO:equivalentTo", source="NCIT:C6357", source="DOID:5331"} +is_a: MONDO:0003125 {source="DOID:5331", source="MONDO:Redundant", source="NCIT:C6357"} ! testicular sex cord-stromal neoplasm +is_a: MONDO:0006036 {source="DOID:5331", source="MONDO:Redundant", source="NCIT:C6357"} ! granulosa cell tumor +intersection_of: MONDO:0006036 ! granulosa cell tumor +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:5331 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336709 +property_value: exactMatch NCIT:C6357 +property_value: excluded_subClassOf MONDO:0000624 {source="DOID:5331"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0003403 +name: testicular non-seminomatous germ cell cancer +def: "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor." [NCIT:C5027] +comment: Editor note: TODO owldef +synonym: "malignant non-seminomatous germ cell cancer of testis" EXACT [NCIT:C5027] +synonym: "malignant non-seminomatous germ cell cancer of the testis" EXACT [NCIT:C5027] +synonym: "malignant non-seminomatous germ cell neoplasm of testis" EXACT [NCIT:C5027] +synonym: "malignant non-seminomatous germ cell neoplasm of the testis" EXACT [NCIT:C5027] +synonym: "malignant non-seminomatous germ cell tumor of testis" EXACT [DOID:5345, NCIT:C5027] +synonym: "malignant non-seminomatous germ cell tumor of the testis" EXACT [NCIT:C5027] +synonym: "malignant testicular non-seminomatous germ cell neoplasm" EXACT [NCIT:C5027] +synonym: "malignant testicular non-seminomatous germ cell tumor" EXACT [NCIT:C5027] +synonym: "testicular germ cell tumor non-seminomatous, malignant" EXACT [MONDO:patterns/malignant] +synonym: "testicular non-seminomatous germ cell cancer" EXACT [NCIT:C5027] +synonym: "testicular non-seminomatous germ cell tumor, malignant" EXACT [MONDO:patterns/malignant] +synonym: "testicular non-seminomatous malignant germ cell neoplasm" EXACT [NCIT:C5027] +xref: DOID:5345 {source="MONDO:equivalentTo"} +xref: NCIT:C5027 {source="DOID:5345", source="MONDO:equivalentTo"} +xref: UMLS:C1334625 {source="DOID:5345", source="MONDO:equivalentTo", source="NCIT:C5027"} +is_a: MONDO:0003510 {source="DOID:5345", source="MONDO:Redundant", source="NCIT:C5027"} ! malignant testicular germ cell tumor +is_a: MONDO:0006447 {source="MONDO:Redundant", source="NCIT:C5027"} ! testicular non-seminomatous germ cell tumor +intersection_of: MONDO:0006447 ! testicular non-seminomatous germ cell tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch DOID:5345 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334625 +property_value: exactMatch NCIT:C5027 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0003406 +name: sleep-wake disorder +def: "Abnormal sleep-wake schedule or pattern associated with the circadian rhythm which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle." [MESH:D012893] +synonym: "circadian dysregulation" RELATED [] +synonym: "disorder of sleep-wake cycle" EXACT [] +synonym: "disorder of sleep-wake schedule" RELATED [] +synonym: "disorder, sleep" RELATED [MESH:D012893] +synonym: "disorder, sleep wake" RELATED [MESH:D012893] +synonym: "disorders of the sleep-wake schedule" RELATED [] +synonym: "disorders, sleep" RELATED [MESH:D012893] +synonym: "disorders, sleep wake" RELATED [MESH:D012893] +synonym: "disturbed nyctohemeral rhythm" RELATED [] +synonym: "long sleeper syndrome" RELATED [MESH:D012893] +synonym: "long sleeper syndromes" RELATED [MESH:D012893] +synonym: "neurogenic tachypnea, sleep-related" RELATED [MESH:D012893] +synonym: "neurogenic Tachypneas, sleep-related" RELATED [MESH:D012893] +synonym: "non-organic sleep disorder" RELATED [DOID:535] +synonym: "phenotype, short sleep" RELATED [MESH:D012893] +synonym: "phenotypes, short sleep" RELATED [MESH:D012893] +synonym: "short sleep phenotype" RELATED [MESH:D012893] +synonym: "short sleep phenotypes" RELATED [MESH:D012893] +synonym: "short sleeper syndrome" RELATED [MESH:D012893] +synonym: "short sleeper syndromes" RELATED [MESH:D012893] +synonym: "sleep disorder" RELATED [MESH:D012893] +synonym: "sleep disorders" RELATED [MESH:D012893] +synonym: "sleep phenotypes, short" RELATED [MESH:D012893] +synonym: "sleep related neurogenic tachypnea" RELATED [MESH:D012893] +synonym: "sleep wake disorder" EXACT [MESH:D012893] +synonym: "sleep-related neurogenic tachypnea" RELATED [MESH:D012893] +synonym: "sleep-related neurogenic Tachypneas" RELATED [MESH:D012893] +synonym: "sleeper syndrome, long" RELATED [MESH:D012893] +synonym: "sleeper syndrome, short" RELATED [MESH:D012893] +synonym: "sleeper syndromes, long" RELATED [MESH:D012893] +synonym: "sleeper syndromes, short" RELATED [MESH:D012893] +synonym: "Subwakefullness syndrome" RELATED [MESH:D012893] +synonym: "Subwakefullness syndromes" RELATED [MESH:D012893] +synonym: "syndrome, long sleeper" RELATED [MESH:D012893] +synonym: "syndrome, short sleeper" RELATED [MESH:D012893] +synonym: "syndrome, Subwakefullness" RELATED [MESH:D012893] +synonym: "syndromes, long sleeper" RELATED [MESH:D012893] +synonym: "syndromes, short sleeper" RELATED [MESH:D012893] +synonym: "syndromes, Subwakefullness" RELATED [MESH:D012893] +synonym: "tachypnea, sleep-related neurogenic" RELATED [MESH:D012893] +synonym: "Tachypneas, sleep-related neurogenic" RELATED [MESH:D012893] +synonym: "wake disorder, sleep" RELATED [MESH:D012893] +synonym: "wake disorders, sleep" RELATED [MESH:D012893] +xref: DOID:535 {source="MONDO:equivalentTo"} +xref: EFO:0008568 {source="MONDO:equivalentTo"} +xref: ICD10CM:G47 {source="MONDO:equivalentTo"} +xref: ICD9:307.4 {source="DOID:535"} +xref: ICD9:307.40 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:307.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012893 {source="MONDO:equivalentTo"} +xref: SCTID:39898005 {source="MONDO:equivalentTo"} +is_a: MONDO:0100081 {source="https://github.com/monarch-initiative/mondo/issues/531"} ! sleep disorder +property_value: exactMatch DOID:535 +property_value: exactMatch http://identifiers.org/mesh/D012893 +property_value: exactMatch http://identifiers.org/snomedct/39898005 +property_value: exactMatch https://icd.codes/icd10cm/G47 +property_value: excluded_subClassOf MONDO:0002025 {source="MESH:D012893"} +property_value: excluded_subClassOf MONDO:0005071 {source="EFO:0008568/inferred", source="ICD10CM:G47/inferred", source="MESH:D012893", source="MESH:D012893/inferred"} + +[Term] +id: MONDO:0003409 +name: colonic disorder +def: "Pathological processes in the colon region of the large intestine (intestine, large)." [MESH:D003108] +synonym: "colon disease" EXACT [MONDO:patterns/location] +synonym: "colon disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "colon disorder" EXACT [DOID:5353] +synonym: "disease of colon" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of colon" EXACT [] +synonym: "disorder of colon" EXACT [MONDO:patterns/location_top] +xref: DOID:5353 {source="MONDO:equivalentTo"} +xref: MESH:D003108 {source="MONDO:equivalentTo", source="DOID:5353"} +xref: SCTID:128524007 {source="MONDO:equivalentTo", source="DOID:5353"} +xref: UMLS:C0009373 {source="MONDO:equivalentTo", source="DOID:5353"} +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001155 ! colon +relationship: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:5353 +property_value: exactMatch http://identifiers.org/mesh/D003108 +property_value: exactMatch http://identifiers.org/snomedct/128524007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009373 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003410 +name: Wolffian duct adenocarcinoma +def: "A cervical adenocarcinoma that arises from mesonephric remnants. It is usually characterized by the presence of tubular glands lined by cuboidal epithelial cells." [NCIT:C40254] +synonym: "cervical mesonephric adenocarcinoma" EXACT [NCIT:C40254] +synonym: "mesonephric duct adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "Wolffian duct adenocarcinoma" EXACT [NCIT:C40254] +xref: DOID:5368 {source="MONDO:equivalentTo"} +xref: NCIT:C40254 {source="DOID:5368", source="MONDO:equivalentTo"} +xref: UMLS:C1516419 {source="DOID:5368", source="MONDO:equivalentTo", source="NCIT:C40254"} +is_a: MONDO:0005086 ! renal cell carcinoma +is_a: MONDO:0005153 {source="DOID:5368", source="NCIT:C40254"} ! cervical adenocarcinoma +is_a: MONDO:0005613 {source="NCIT:C40254"} ! mesonephric adenocarcinoma +is_a: MONDO:0024888 ! mesonephric neoplasm +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0003074 ! mesonephric duct +property_value: exactMatch DOID:5368 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1516419 +property_value: exactMatch NCIT:C40254 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003413 +name: hair follicle neoplasm +def: "A benign or malignant neoplasm arising from the hair follicle." [NCIT:C7367] +synonym: "hair follicle neoplasm" EXACT [NCIT:C7367] +synonym: "hair follicle neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "hair follicle tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C7367] +synonym: "hair matrix neoplasm" RELATED [DOID:5375, NCIT:C7367] +synonym: "hair matrix tumor" RELATED [NCIT:C7367] +synonym: "hair matrix tumour" RELATED [DOID:5375] +synonym: "neoplasm of hair follicle" EXACT [MONDO:patterns/neoplasm, NCIT:C7367] +synonym: "neoplasm of the hair follicle" EXACT [NCIT:C7367] +synonym: "tumor of hair follicle" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5375 {source="MONDO:equivalentTo"} +xref: NCIT:C7367 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:5375"} +xref: UMLS:C0859920 {source="NCIT:C7367", source="MONDO:equivalentTo", source="DOID:5375"} +is_a: MONDO:0002297 {source="NCIT:C7367"} ! epidermal appendage tumor +is_a: MONDO:0002917 {source="MONDO:Redundant", source="NCIT:C7367"} ! disorder of pilosebaceous unit +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002073 ! hair follicle +relationship: disease_has_location UBERON:0002073 ! hair follicle +property_value: exactMatch DOID:5375 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0859920 +property_value: exactMatch NCIT:C7367 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003442 +name: bladder papillary urothelial neoplasm +def: "A papillary epithelial neoplasm that involves the urinary bladder urothelium." [MONDO:patterns/location] +synonym: "bladder papillary transitional cell neoplasm" EXACT [NCIT:C39857] +synonym: "bladder papillary urothelial neoplasm" EXACT [NCIT:C39857] +synonym: "urinary bladder papillary transitional cell neoplasm" EXACT [NCIT:C39857] +synonym: "urinary bladder papillary urothelial neoplasm" EXACT [NCIT:C39857] +synonym: "urinary bladder urothelium papillary epithelial neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:5432 {source="MONDO:equivalentTo"} +xref: NCIT:C39857 {source="DOID:5432", source="MONDO:equivalentTo"} +xref: UMLS:C1511197 {source="DOID:5432", source="MONDO:equivalentTo", source="NCIT:C39857"} +is_a: MONDO:0003443 {source="DOID:5432", source="MONDO:Redundant", source="NCIT:C39857"} ! papillary urothelial neoplasm +is_a: MONDO:0004987 {source="MONDO:Redundant", source="NCIT:C39857"} ! urinary bladder neoplasm +intersection_of: MONDO:0021096 ! papillary epithelial neoplasm +intersection_of: disease_has_location UBERON:0004645 ! urinary bladder urothelium +relationship: disease_arises_from_structure CL:1001428 {source="NCIT:C39857"} ! bladder urothelial cell +relationship: disease_has_location UBERON:0004645 ! urinary bladder urothelium +property_value: exactMatch DOID:5432 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511197 +property_value: exactMatch NCIT:C39857 + +[Term] +id: MONDO:0003443 +name: papillary urothelial neoplasm +def: "A neoplastic lesion of the urinary tract transitional cell epithelium characterized by papillary formations. -- 2003" [NCIT:C27883] +synonym: "inverted papilloma of urinary tract" RELATED [DOID:5433, NCIT:C6192] +synonym: "papillary transitional cell neoplasm of the urinary tract" EXACT [DOID:5433, NCIT:C27883] +synonym: "papillary urothelial neoplasm" EXACT [NCIT:C27883] +synonym: "urinary tract papillary transitional cell benign neoplasm" RELATED [DOID:5433] +synonym: "urinary tract papillary transitional cell neoplasm" EXACT [NCIT:C27883] +synonym: "urothelium papillary epithelial neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:5433 {source="MONDO:equivalentTo"} +xref: NCIT:C27883 {source="DOID:5433", source="MONDO:equivalentTo"} +xref: UMLS:C1335329 {source="DOID:5433", source="NCIT:C27883", source="MONDO:equivalentTo"} +is_a: MONDO:0021096 {source="MONDO:Redundant", source="NCIT:C27883"} ! papillary epithelial neoplasm +is_a: MONDO:0024337 ! urothelial neoplasm +intersection_of: MONDO:0021096 ! papillary epithelial neoplasm +intersection_of: disease_has_location UBERON:0000365 ! urothelium +property_value: exactMatch DOID:5433 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335329 +property_value: exactMatch NCIT:C27883 + +[Term] +id: MONDO:0003452 +name: cochlear disorder +def: "Pathological processes of the snail-like structure (cochlea) of the inner ear (labyrinth) which can involve its nervous tissue, blood vessels, or fluid (endolymph)." [MESH:D015834] +synonym: "cochlea disease" EXACT [MONDO:patterns/location] +synonym: "cochlea disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of cochlea" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cochlea" EXACT [] +synonym: "disorder of cochlea" EXACT [MONDO:patterns/location_top] +xref: DOID:5463 {source="MONDO:equivalentTo"} +xref: MESH:D015834 {source="MONDO:equivalentTo", source="DOID:5463"} +xref: UMLS:C0009197 {source="MONDO:equivalentTo", source="DOID:5463"} +is_a: MONDO:0002467 ! inner ear disorder +is_a: MONDO:0024654 ! skull disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001844 ! cochlea +relationship: disease_has_location UBERON:0001844 ! cochlea +property_value: exactMatch DOID:5463 +property_value: exactMatch http://identifiers.org/mesh/D015834 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009197 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003454 +name: conjunctival cancer +def: "A malignant neoplasm involving the conjunctiva." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of conjunctiva" BROAD [MONDO:patterns/cancer] +synonym: "conjunctiva cancer" EXACT [MONDO:patterns/location] +synonym: "conjunctival tumor" BROAD [DOID:5467, NCIT:C2961] +synonym: "malignant conjunctiva neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3564] +synonym: "malignant conjunctiva tumor" EXACT [NCIT:C3564] +synonym: "malignant conjunctival neoplasm" EXACT [NCIT:C3564] +synonym: "malignant conjunctival tumor" EXACT [DOID:5467, NCIT:C3564] +synonym: "malignant neoplasm of conjunctiva" EXACT [DOID:5467, MONDO:patterns/cancer, NCIT:C3564] +synonym: "malignant neoplasm of conjunctiva (primary)" EXACT [DOID:5467] +synonym: "malignant neoplasm of the conjunctiva" EXACT [NCIT:C3564] +synonym: "malignant tumor of conjunctiva" EXACT [NCIT:C3564] +synonym: "malignant tumor of the conjunctiva" EXACT [NCIT:C3564] +xref: DOID:5467 {source="MONDO:equivalentTo"} +xref: ICD9:190.3 {source="DOID:5467", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3564 {source="DOID:5467", source="MONDO:equivalentTo"} +xref: SCTID:363463000 {source="DOID:5467", source="MONDO:equivalentTo"} +is_a: MONDO:0002236 {source="DOID:5467", source="MONDO:Redundant", source="NCIT:C3564"} ! ocular cancer +is_a: MONDO:0020204 {source="MONDO:Redundant", source="NCIT:C3564"} ! conjunctival tumor +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:5467 +property_value: exactMatch http://identifiers.org/snomedct/363463000 +property_value: exactMatch NCIT:C3564 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003455 +name: bile duct papillary neoplasm +def: "A non-invasive, papillary epithelial neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts." [NCIT:P378] +synonym: "bile duct papillary epithelial neoplasm" EXACT [MONDO:patterns/location] +synonym: "bile duct papillary neoplasm" EXACT [NCIT:C6881] +synonym: "bile duct papillomatosis" EXACT [NCIT:C6881] +synonym: "biliary papillomatosis" EXACT [DOID:5468, NCIT:C6881] +synonym: "intraductal papillary neoplasm" EXACT [NCIT:C6881] +synonym: "IPN" EXACT ABBREVIATION [NCIT:C6881] +xref: DOID:5468 {source="MONDO:equivalentTo"} +xref: ICDO:8503/0 {source="NCIT:C6881"} +xref: NCIT:C6881 {source="MONDO:equivalentTo"} +xref: UMLS:C1879344 {source="NCIT:C6881", source="MONDO:equivalentTo"} +is_a: MONDO:0000385 ! benign digestive system neoplasm +is_a: MONDO:0000627 ! benign endocrine neoplasm +is_a: MONDO:0002060 ! intraductal papilloma +is_a: MONDO:0021662 {source="MONDO:Redundant", source="NCIT:C6881"} ! bile duct neoplasm +intersection_of: MONDO:0021096 ! papillary epithelial neoplasm +intersection_of: disease_has_location UBERON:0002394 ! bile duct +relationship: disease_arises_from_structure UBERON:0004820 {source="NCIT:C6881"} ! bile duct epithelium +property_value: exactMatch DOID:5468 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1879344 +property_value: exactMatch NCIT:C6881 + +[Term] +id: MONDO:0003473 +name: spinal cord ependymoma +alt_id: MONDO:0021544 +def: "An ependymoma that arises from the spinal cord." [NCIT:C3875] +synonym: "ependymal neoplasm of the spinal cord" EXACT [DOID:5503, NCIT:C3875] +synonym: "ependymoma of spinal cord" EXACT [NCIT:C3875] +synonym: "ependymoma of the spinal cord" EXACT [NCIT:C3875] +synonym: "spinal cord ependymoma" EXACT [MONDO:patterns/location, NCIT:C3875] +xref: DOID:5503 {source="MONDO:equivalentTo"} +xref: NCIT:C3875 {source="MONDO:equivalentTo", source="DOID:5503"} +xref: SCTID:254949006 {source="MONDO:equivalentTo", source="DOID:5503"} +xref: UMLS:C0238432 {source="MONDO:equivalentTo", source="DOID:5503", source="NCIT:C3875"} +is_a: MONDO:0016698 {source="MONDO:Redundant", source="NCIT:C3875"} ! ependymoma +is_a: MONDO:0021546 {source="MONDO:Redundant", source="NCIT:C3875"} ! ependymal tumor of spinal cord +intersection_of: MONDO:0016698 ! ependymoma +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:5503 +property_value: exactMatch http://identifiers.org/snomedct/254949006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238432 +property_value: exactMatch NCIT:C3875 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003477 +name: brain stem ependymoma +def: "An ependymoma that arises from the brain stem." [NCIT:C5098] +synonym: "brain stem ependymoma" EXACT [NCIT:C5098] +synonym: "brainstem ependymoma" EXACT [MONDO:patterns/location, NCIT:C5098] +synonym: "ependymoma of brain stem" EXACT [NCIT:C5098] +synonym: "ependymoma of brainstem" EXACT [NCIT:C5098] +synonym: "ependymoma of the brain stem" EXACT [NCIT:C5098] +synonym: "ependymoma of the brainstem" EXACT [DOID:5508, NCIT:C5098] +xref: DOID:5508 {source="MONDO:equivalentTo"} +xref: NCIT:C5098 {source="MONDO:equivalentTo", source="DOID:5508", source="MONDO:exact-label-match"} +xref: UMLS:C1332609 {source="NCIT:C5098", source="MONDO:equivalentTo", source="DOID:5508"} +is_a: MONDO:0002911 {source="DOID:5508", source="MONDO:Redundant", source="NCIT:C5098"} ! brain stem glioma +is_a: MONDO:0004245 {source="MONDO:Redundant", source="NCIT:C5098"} ! ependymal tumor of brain +is_a: MONDO:0016698 {source="MONDO:Redundant", source="NCIT:C5098"} ! ependymoma +intersection_of: MONDO:0016698 ! ependymoma +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch DOID:5508 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332609 +property_value: exactMatch NCIT:C5098 + +[Term] +id: MONDO:0003478 +name: childhood ependymoma +def: "An ependymoma that arises from the central nervous system and occurs during childhood." [NCIT:C8578] +synonym: "childhood ependymoma" EXACT [DOID:5509, NCIT:C8578] +synonym: "ependymoma" BROAD [NCIT:C8578] +synonym: "ependymoma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric ependymoma" EXACT [MONDO:patterns/childhood, NCIT:C8578] +xref: DOID:5509 {source="MONDO:equivalentTo"} +xref: MESH:C531673 {source="MONDO:equivalentTo"} +xref: NCIT:C8578 {source="MONDO:equivalentTo", source="DOID:5509"} +is_a: MONDO:0016698 {source="MESH:C531673", source="MONDO:Redundant", source="NCIT:C8578"} ! ependymoma +is_a: MONDO:0021079 ! childhood neoplasm +intersection_of: MONDO:0016698 ! ependymoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:5509 +property_value: exactMatch http://identifiers.org/mesh/C531673 +property_value: exactMatch NCIT:C8578 + +[Term] +id: MONDO:0003490 +name: ampulla of vater squamous cell carcinoma +def: "A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss." [NCIT:C27417] +synonym: "ampulla of Vater squamous cell carcinoma" EXACT [NCIT:C27417] +synonym: "hepatopancreatic ampulla squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:5527 {source="MONDO:equivalentTo"} +xref: NCIT:C27417 {source="MONDO:equivalentTo", source="DOID:5527", source="MONDO:exact-label-match"} +xref: UMLS:C1332251 {source="MONDO:equivalentTo", source="DOID:5527", source="NCIT:C27417"} +is_a: MONDO:0006203 ! extrahepatic bile duct squamous cell carcinoma +is_a: MONDO:0017590 {source="DOID:5527", source="MONDO:Redundant", source="NCIT:C27417"} ! carcinoma of the ampulla of vater +is_a: MONDO:0018509 ! squamous cell carcinoma of the small intestine +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +property_value: exactMatch DOID:5527 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332251 +property_value: exactMatch NCIT:C27417 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003492 +name: lacrimal gland squamous cell carcinoma +def: "A squamous cell carcinoma that involves the lacrimal gland." [MONDO:patterns/location] +synonym: "epidermoid carcinoma of lacrimal gland" EXACT [NCIT:C6092] +synonym: "epidermoid carcinoma of the lacrimal gland" EXACT [DOID:5529, NCIT:C6092] +synonym: "lacrimal gland epidermoid carcinoma" EXACT [NCIT:C6092] +synonym: "lacrimal gland squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6092] +synonym: "squamous cell carcinoma of lacrimal gland" EXACT [DOID:5529, NCIT:C6092] +synonym: "squamous cell carcinoma of the lacrimal gland" EXACT [NCIT:C6092] +xref: DOID:5529 {source="MONDO:equivalentTo"} +xref: NCIT:C6092 {source="MONDO:equivalentTo", source="DOID:5529", source="MONDO:exact-label-match"} +xref: UMLS:C1334360 {source="MONDO:equivalentTo", source="NCIT:C6092", source="DOID:5529"} +is_a: MONDO:0002463 {source="DOID:5529", source="MONDO:Redundant", source="NCIT:C6092"} ! lacrimal gland carcinoma +is_a: MONDO:0010150 ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch DOID:5529 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334360 +property_value: exactMatch NCIT:C6092 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003493 +name: thymus squamous cell carcinoma +def: "A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. Approximately 10-20% of cases occur in combination with thymoma. The prognosis depends on the tumor stage and the degree of cellular differentiation." [NCIT:C6455] +synonym: "epidermoid thymic carcinoma" EXACT [DOID:5530, NCIT:C6455] +synonym: "squamous cell carcinoma of the Thymus" EXACT [NCIT:C6455] +synonym: "squamous cell carcinoma of Thymus" EXACT [NCIT:C6455] +synonym: "thymic squamous cell carcinoma" EXACT [MONDO:0006454, NCIT:C6455] +synonym: "Thymus squamous cell carcinoma" EXACT [NCIT:C6455] +synonym: "thymus squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:5530 {source="MONDO:equivalentTo"} +xref: EFO:1000579 {source="MONDO:equivalentTo"} +xref: NCIT:C6455 {source="DOID:5530", source="MONDO:equivalentTo", source="EFO:1000579"} +xref: UMLS:C1336082 {source="DOID:5530", source="MONDO:equivalentTo", source="NCIT:C6455"} +is_a: MONDO:0005096 {source="DOID:5530", source="EFO:1000579", source="MONDO:Redundant", source="NCIT:C6455"} ! squamous cell carcinoma +is_a: MONDO:0006451 {source="DOID:5530", source="MONDO:Redundant", source="NCIT:C6455"} ! thymic carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch DOID:5530 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336082 +property_value: exactMatch NCIT:C6455 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003494 +name: ovarian squamous cell carcinoma +def: "A usually high grade squamous cell carcinoma that arises from the ovary and is not associated with a germ cell tumor. The prognosis is poor." [NCIT:C40093] +synonym: "ovarian squamous cell cancer" EXACT [NCIT:C40093] +synonym: "ovarian squamous cell carcinoma" EXACT [MONDO:0006342, NCIT:C40093] +synonym: "ovary squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:5531 {source="MONDO:equivalentTo"} +xref: EFO:1000432 {source="MONDO:equivalentTo"} +xref: NCIT:C40093 {source="DOID:5531", source="EFO:1000432", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C2019443 {source="NCIT:C40093", source="MONDO:equivalentTo"} +is_a: MONDO:0003495 ! ovarian squamous cell neoplasm +is_a: MONDO:0005096 {source="EFO:1000432", source="MONDO:Redundant", source="NCIT:C40093"} ! squamous cell carcinoma +is_a: MONDO:0005140 {source="DOID:5531", source="EFO:1000432", source="MONDO:Entailed", source="NCIT:C40093"} ! ovarian carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:5531 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2019443 +property_value: exactMatch NCIT:C40093 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003495 +name: ovarian squamous cell neoplasm +def: "A squamous cell tumor that arises from the ovary and is not associated with a germ cell tumor." [NCIT:C40092] +synonym: "ovarian squamous cell neoplasm" EXACT [NCIT:C40092] +synonym: "ovarian squamous cell tumor" EXACT [NCIT:C40092] +synonym: "ovary squamous cell neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:5532 {source="MONDO:equivalentTo"} +xref: NCIT:C40092 {source="DOID:5532", source="MONDO:equivalentTo"} +xref: UMLS:C1518739 {source="NCIT:C40092", source="DOID:5532", source="MONDO:equivalentTo"} +is_a: MONDO:0002229 {source="DOID:5532", source="MONDO:Redundant", source="NCIT:C40092"} ! ovarian epithelial tumor +is_a: MONDO:0002532 {source="MONDO:Redundant", source="NCIT:C40092"} ! squamous cell neoplasm +intersection_of: MONDO:0002532 ! squamous cell neoplasm +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:5532 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518739 +property_value: exactMatch NCIT:C40092 + +[Term] +id: MONDO:0003497 +name: renal pelvis squamous cell carcinoma +def: "A squamous cell carcinoma that involves the renal pelvis." [MONDO:patterns/location] +synonym: "epidermoid carcinoma of kidney pelvis" EXACT [NCIT:C7732] +synonym: "epidermoid carcinoma of renal pelvis" EXACT [NCIT:C7732] +synonym: "epidermoid carcinoma of the kidney pelvis" EXACT [DOID:5534, NCIT:C7732] +synonym: "epidermoid carcinoma of the renal pelvis" EXACT [NCIT:C7732] +synonym: "kidney pelvis epidermoid carcinoma" EXACT [NCIT:C7732] +synonym: "kidney pelvis squamous cell carcinoma" EXACT [NCIT:C7732] +synonym: "kidney renal pelvis squamous cell cancer" EXACT [NCIT:C7732] +synonym: "renal pelvis epidermoid carcinoma" EXACT [NCIT:C7732] +synonym: "renal pelvis squamous cell cancer" EXACT [NCIT:C7732] +synonym: "renal pelvis squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C7732] +synonym: "squamous cell carcinoma of kidney pelvis" EXACT [NCIT:C7732] +synonym: "squamous cell carcinoma of renal pelvis" EXACT [DOID:5534, NCIT:C7732] +synonym: "squamous cell carcinoma of the kidney pelvis" EXACT [NCIT:C7732] +synonym: "squamous cell carcinoma of the renal pelvis" EXACT [NCIT:C7732] +xref: DOID:5534 {source="MONDO:equivalentTo"} +xref: NCIT:C7732 {source="DOID:5534", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0238409 {source="DOID:5534", source="MONDO:equivalentTo", source="NCIT:C7732"} +is_a: MONDO:0005096 {source="DOID:5534", source="MONDO:Redundant", source="NCIT:C7732"} ! squamous cell carcinoma +is_a: MONDO:0005519 {source="DOID:5534", source="MONDO:Redundant", source="NCIT:C7732"} ! renal pelvis carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:5534 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238409 +property_value: exactMatch NCIT:C7732 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003500 +name: squamous cell bile duct carcinoma +def: "A squamous cell carcinoma that involves the bile duct." [MONDO:patterns/location] +synonym: "bile duct squamous cell carcinoma" EXACT [DOID:5537, MONDO:patterns/location, NCIT:C5777] +xref: DOID:5537 {source="MONDO:equivalentTo"} +xref: NCIT:C5777 {source="DOID:5537", source="MONDO:directSiblingOf"} +xref: UMLS:C0861861 {source="DOID:5537", source="MONDO:equivalentTo"} +is_a: MONDO:0005496 {source="DOID:5537", source="MONDO:Redundant"} ! bile duct carcinoma +is_a: MONDO:0018534 ! squamous cell carcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch DOID:5537 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0861861 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003501 +name: external ear squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the skin of the external ear." [NCIT:C6083] +synonym: "epidermoid carcinoma of external Ear" EXACT [NCIT:C6083] +synonym: "epidermoid carcinoma of the external Ear" EXACT [NCIT:C6083] +synonym: "epidermoid carcinoma of the external ear" EXACT [DOID:5538, NCIT:C6083] +synonym: "external Ear epidermoid carcinoma" EXACT [NCIT:C6083] +synonym: "external Ear squamous cell carcinoma" EXACT [NCIT:C6083] +synonym: "external ear squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of external Ear" EXACT [NCIT:C6083] +synonym: "squamous cell carcinoma of external ear" RELATED [DOID:5538] +synonym: "squamous cell carcinoma of the external Ear" EXACT [NCIT:C6083] +xref: DOID:5538 {source="MONDO:equivalentTo"} +xref: NCIT:C6083 {source="MONDO:equivalentTo", source="DOID:5538", source="MONDO:exact-label-match"} +xref: UMLS:C1333494 {source="MONDO:equivalentTo", source="DOID:5538", source="NCIT:C6083"} +is_a: MONDO:0002944 {source="DOID:5538", source="MONDO:Redundant", source="NCIT:C6083"} ! external ear carcinoma +is_a: MONDO:0010150 {source="MONDO:Redundant", source="NCIT:C6083/inferred"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch DOID:5538 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333494 +property_value: exactMatch NCIT:C6083 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003502 +name: ureter squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the ureter." [NCIT:C6154] +synonym: "epidermoid carcinoma of the ureter" EXACT [NCIT:C6154] +synonym: "epidermoid carcinoma of ureter" EXACT [NCIT:C6154] +synonym: "squamous cell carcinoma of the ureter" EXACT [NCIT:C6154] +synonym: "squamous cell carcinoma of ureter" EXACT [NCIT:C6154] +synonym: "ureter epidermoid carcinoma" EXACT [NCIT:C6154] +synonym: "ureter squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6154] +synonym: "ureteral epidermoid carcinoma" EXACT [DOID:5539, NCIT:C6154] +synonym: "ureteral squamous cell carcinoma" EXACT [NCIT:C6154] +xref: DOID:5539 {source="MONDO:equivalentTo"} +xref: NCIT:C6154 {source="MONDO:equivalentTo", source="DOID:5539", source="MONDO:exact-label-match"} +xref: UMLS:C1336879 {source="NCIT:C6154", source="MONDO:equivalentTo", source="DOID:5539"} +is_a: MONDO:0005096 {source="DOID:5539", source="MONDO:Redundant", source="NCIT:C6154"} ! squamous cell carcinoma +is_a: MONDO:0006481 {source="DOID:5539", source="MONDO:Redundant", source="NCIT:C6154"} ! ureter carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:5539 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336879 +property_value: exactMatch NCIT:C6154 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003503 +name: fallopian tube squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the fallopian tube." [NCIT:C6282] +synonym: "fallopian tube squamous cell cancer" EXACT [NCIT:C6282] +synonym: "fallopian tube squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6282] +synonym: "squamous cell carcinoma of fallopian tube" EXACT [NCIT:C6282] +synonym: "squamous cell carcinoma of the fallopian tube" EXACT [DOID:5540, NCIT:C6282] +xref: DOID:5540 {source="MONDO:equivalentTo"} +xref: NCIT:C6282 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:5540"} +xref: UMLS:C1333596 {source="MONDO:equivalentTo", source="DOID:5540", source="NCIT:C6282"} +is_a: MONDO:0005096 {source="DOID:5540", source="MONDO:Redundant", source="NCIT:C6282"} ! squamous cell carcinoma +is_a: MONDO:0006206 {source="DOID:5540", source="MONDO:Redundant", source="NCIT:C6282"} ! fallopian tube carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:5540 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333596 +property_value: exactMatch NCIT:C6282 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0003504 +name: anal canal neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the anal canal. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5603] +synonym: "anal canal NET" RELATED [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "anal canal neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5603] +synonym: "anal canal neuroendocrine tumor" RELATED [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "anal canal neuroendocrine tumor, well differentiated, low or intermediate grade" RELATED [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "anal neuroendocrine neoplasm" EXACT [NCIT:C5603] +synonym: "anal neuroendocrine tumor" RELATED [DOID:5545] +synonym: "anus neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "anus neuroendocrine tumor" RELATED [MONDO:patterns/location] +synonym: "neuroendocrine neoplasm of anal canal" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of anus" EXACT [NCIT:C5603] +synonym: "neuroendocrine neoplasm of the anus" EXACT [NCIT:C5603] +synonym: "neuroendocrine tumor of anus" RELATED [DOID:5545, NCIT:C5603] +xref: DOID:5545 {source="MONDO:equivalentTo"} +xref: NCIT:C5603 {source="DOID:5545", source="MONDO:equivalentTo"} +xref: SCTID:717917007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002120 ! neuroendocrine carcinoma +is_a: MONDO:0003646 ! rectum neuroendocrine neoplasm +is_a: MONDO:0007108 ! anal canal carcinoma +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000159 ! anal canal +property_value: exactMatch DOID:5545 +property_value: exactMatch http://identifiers.org/snomedct/717917007 +property_value: exactMatch NCIT:C5603 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0003505 +name: femoral cancer +def: "A cancer involving a femur." [MONDO:patterns/cancer] +synonym: "cancer of femur" EXACT [MONDO:patterns/cancer] +synonym: "femoral neoplasm" BROAD [DOID:5546] +synonym: "femur cancer" EXACT [MONDO:patterns/location] +synonym: "malignant femur neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of femur" EXACT [MONDO:patterns/cancer] +synonym: "neoplasm of femur" BROAD [DOID:5546] +xref: DOID:5546 {source="MONDO:equivalentTo"} +xref: EFO:0007270 {source="MONDO:equivalentTo"} +xref: MESH:D005266 {source="DOID:5546", source="MONDO:equivalentTo"} +xref: SCTID:126583006 {source="DOID:5546", source="MONDO:directSiblingOf"} +is_a: MONDO:0000952 ! cancer of long bone of lower limb +is_a: MONDO:0021579 ! neoplasm of femur +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000981 ! femur +property_value: exactMatch DOID:5546 +property_value: exactMatch http://identifiers.org/mesh/D005266 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003510 +name: malignant testicular germ cell tumor +def: "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor." [NCIT:C9063] +synonym: "malignant germ cell neoplasm of testis" EXACT [NCIT:C9063] +synonym: "malignant germ cell neoplasm of the testis" EXACT [NCIT:C9063] +synonym: "malignant germ cell tumor of testis" EXACT [DOID:5556, NCIT:C9063] +synonym: "malignant germ cell tumor of the testis" EXACT [NCIT:C9063] +synonym: "malignant testicular germ cell neoplasm" EXACT [NCIT:C9063] +synonym: "malignant testicular germ cell tumor" EXACT [NCIT:C9063] +synonym: "testicular ca. (no germ/tropho.)" EXACT [NCIT:C9063] +synonym: "testicular cancer" BROAD [NCIT:C9063] +synonym: "testicular cancer (excluding germ cell or trophoblastic cancer)" EXACT [NCIT:C9063] +synonym: "testicular germ cell cancer" EXACT [NCIT:C9063] +synonym: "testicular malignant germ cell cancer" RELATED [DOID:5556] +xref: DOID:5556 {source="MONDO:equivalentTo"} +xref: ICD9:186.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C9063 {source="DOID:5556", source="MONDO:equivalentTo"} +xref: SCTID:713646001 {source="DOID:5556", source="MONDO:equivalentTo"} +xref: UMLS:C0855197 {source="DOID:5556", source="MONDO:equivalentTo", source="NCIT:C9063"} +is_a: MONDO:0005447 {source="DOID:5556/inferred", source="MONDO:Redundant", source="NCIT:C9063"} ! testicular cancer +is_a: MONDO:0006290 {source="MONDO:Redundant", source="NCIT:C9063"} ! malignant germ cell tumor +is_a: MONDO:0010108 {source="DOID:5556", source="MONDO:Redundant", source="NCIT:C9063"} ! testicular germ cell tumor +intersection_of: MONDO:0004992 ! cancer +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:5556 +property_value: exactMatch http://identifiers.org/snomedct/713646001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0855197 +property_value: exactMatch NCIT:C9063 + +[Term] +id: MONDO:0003543 +name: trigeminal nerve disorder +def: "A disease involving the trigeminal nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of trigeminal nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of trigeminal nerve" EXACT [] +synonym: "disorder of the fifth cranial nerve" RELATED [] +synonym: "disorder of trigeminal nerve" EXACT [MONDO:patterns/location_top] +synonym: "disorders of the fifth nerve" RELATED [] +synonym: "disorders of the vth cranial nerve" RELATED [] +synonym: "trigeminal nerve disease" EXACT [MONDO:patterns/location] +synonym: "trigeminal nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "trigeminal nerve disorder" EXACT [] +xref: DOID:561 {source="MONDO:equivalentTo"} +xref: ICD9:350.8 {source="DOID:561"} +xref: MESH:D020433 {source="MONDO:equivalentTo"} +xref: NCIT:C26952 {source="MONDO:equivalentTo"} +xref: SCTID:64309007 {source="MONDO:equivalentTo"} +is_a: MONDO:0003569 {source="DOID:561", source="MESH:D020433/inferred", source="MONDO:Redundant", source="NCIT:C26952"} ! cranial nerve neuropathy +is_a: MONDO:0003620 {source="DOID:561/inferred", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001645 ! trigeminal nerve +relationship: disease_has_location UBERON:0001645 ! trigeminal nerve +property_value: exactMatch DOID:561 +property_value: exactMatch http://identifiers.org/mesh/D020433 +property_value: exactMatch http://identifiers.org/snomedct/64309007 +property_value: exactMatch NCIT:C26952 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003544 +name: spinal cord cancer +def: "A primary or metastatic malignant neoplasm affecting the spinal cord. Representative examples include lymphoma, melanoma, and sarcoma." [NCIT:C3572] +synonym: "cancer of spinal cord" EXACT [MONDO:patterns/cancer] +synonym: "intraspinal tumor" BROAD [DOID:5612, NCIT:C3382] +synonym: "malignant neoplasm of spinal cord" EXACT [MONDO:patterns/cancer, NCIT:C3572] +synonym: "malignant neoplasm of the spinal cord" EXACT [NCIT:C3572] +synonym: "malignant spinal cord neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3572] +synonym: "malignant spinal cord tumor" EXACT [NCIT:C3572] +synonym: "malignant tumor of spinal cord" EXACT [NCIT:C3572] +synonym: "malignant tumor of the spinal cord" EXACT [DOID:5612, NCIT:C3572] +synonym: "spinal cancer" EXACT [DOID:5612] +synonym: "spinal cord cancer" EXACT [MONDO:patterns/location] +synonym: "spinal cord neoplasm" BROAD [DOID:5612] +synonym: "spinal neoplasm" RELATED [DOID:5612] +synonym: "spine cancer" EXACT [NCIT:C3572] +synonym: "tumor of the spinal cord" BROAD [DOID:5612, NCIT:C3381] +xref: DOID:5612 {source="MONDO:equivalentTo"} +xref: ICD10CM:C72.0 {source="DOID:5612", source="MONDO:equivalentTo"} +xref: ICD9:192.2 {source="DOID:5612", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3572 {source="DOID:5612", source="MONDO:equivalentTo"} +xref: SCTID:363475005 {source="DOID:5612", source="MONDO:equivalentTo"} +xref: UMLS:C0153646 {source="DOID:5612", source="NCIT:C3572", source="MONDO:equivalentTo"} +is_a: MONDO:0002714 {source="DOID:5612", source="MONDO:Redundant", source="NCIT:C3572"} ! central nervous system cancer +is_a: MONDO:0021234 {source="MONDO:Redundant", source="NCIT:C3572"} ! spinal cord neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch DOID:5612 +property_value: exactMatch http://identifiers.org/snomedct/363475005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153646 +property_value: exactMatch https://icd.codes/icd10cm/C72.0 +property_value: exactMatch NCIT:C3572 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003546 +name: third cranial nerve disorder +def: "A disease involving the oculomotor nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of oculomotor nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of oculomotor nerve" EXACT [] +synonym: "disorder of oculomotor nerve" EXACT [DOID:562, MONDO:patterns/location_top] +synonym: "oculomotor nerve disease" EXACT [MONDO:patterns/location] +synonym: "oculomotor nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "oculomotor nerve disorder" EXACT [DOID:562, NCIT:C27598] +xref: DOID:562 {source="MONDO:equivalentTo"} +xref: MESH:D015840 {source="MONDO:equivalentTo"} +xref: NCIT:C27598 {source="MONDO:equivalentTo", source="DOID:562"} +xref: SCTID:60750009 {source="MONDO:equivalentTo", source="DOID:562"} +xref: UMLS:C0271353 {source="NCIT:C27598", source="MONDO:equivalentTo", source="DOID:562"} +is_a: MONDO:0003569 {source="DOID:562", source="MESH:D015840/inferred", source="MONDO:Redundant", source="NCIT:C27598"} ! cranial nerve neuropathy +is_a: MONDO:0003620 {source="DOID:562/inferred", source="MONDO:Redundant"} ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001643 ! oculomotor nerve +relationship: disease_has_location UBERON:0001643 ! oculomotor nerve +property_value: exactMatch DOID:562 +property_value: exactMatch http://identifiers.org/mesh/D015840 +property_value: exactMatch http://identifiers.org/snomedct/60750009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271353 +property_value: exactMatch NCIT:C27598 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003562 +name: rete testis neoplasm +def: "A benign or malignant neoplasm that affects the rete testis. Representative examples include adenoma and adenocarcinoma." [NCIT:C39955] +synonym: "neoplasm of rete testis" EXACT [MONDO:patterns/neoplasm] +synonym: "rete testis neoplasm" EXACT [NCIT:C39955] +synonym: "rete testis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "rete testis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of rete testis" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5639 {source="MONDO:equivalentTo"} +xref: NCIT:C39955 {source="MONDO:equivalentTo", source="DOID:5639", source="MONDO:exact-label-match"} +xref: UMLS:C1514912 {source="MONDO:equivalentTo", source="NCIT:C39955", source="DOID:5639"} +is_a: MONDO:0021348 ! neoplasm of testis +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003959 ! rete testis +relationship: disease_has_location UBERON:0003959 ! rete testis +property_value: exactMatch DOID:5639 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514912 +property_value: exactMatch NCIT:C39955 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003568 +name: disorder of optic chiasm +def: "A disease that involves the optic chiasma." [MONDO:patterns/location] +synonym: "chiasma syndrome" EXACT [DOID:5655] +synonym: "chiasmal syndrome" EXACT [DOID:5655, Wikipedia:Chiasmal_syndrome] +synonym: "disease of optic chiasma" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of optic chiasma" EXACT [] +synonym: "disorder of optic chiasm" EXACT [DOID:5655, ICD9CM:377.5] +synonym: "disorder of optic chiasma" EXACT [MONDO:patterns/location_top] +synonym: "optic chiasma disease" EXACT [] +synonym: "optic chiasma disease or disorder" EXACT [MONDO:patterns/location] +xref: DOID:5655 {source="MONDO:equivalentTo"} +xref: ICD10CM:H47.4 {source="DOID:5655", source="MONDO:equivalentTo"} +xref: ICD9:377.5 {source="DOID:5655"} +xref: ICD9:377.63 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:70476006 {source="DOID:5655", source="MONDO:equivalentTo"} +xref: UMLS:C0155307 {source="DOID:5655", source="MONDO:equivalentTo"} +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000959 ! optic chiasma +relationship: disease_has_location UBERON:0000959 ! optic chiasma +property_value: exactMatch DOID:5655 +property_value: exactMatch http://identifiers.org/snomedct/70476006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155307 +property_value: exactMatch https://icd.codes/icd10cm/H47.4 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003569 +name: cranial nerve neuropathy +def: "A neoplastic or non-neoplastic disorder that affects one of the cranial nerves." [NCIT:C26733] +synonym: "cranial nerve disease" EXACT [NCIT:C26733] +synonym: "cranial nerve disorder" EXACT [DOID:5656, NCIT:C26733] +synonym: "cranial neuron projection bundle disease" EXACT [MONDO:patterns/location] +synonym: "cranial neuron projection bundle disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "cranial neuropathy" EXACT [NCIT:C26733] +synonym: "disease of cranial neuron projection bundle" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cranial neuron projection bundle" EXACT [] +synonym: "disorder of cranial nerve" EXACT [DOID:5656, NCIT:C26733] +synonym: "disorder of cranial neuron projection bundle" EXACT [MONDO:patterns/location_top] +xref: DOID:5656 {source="MONDO:equivalentTo"} +xref: ICD9:352.9 {source="DOID:5656", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D003389 {source="DOID:5656", source="MONDO:equivalentTo"} +xref: NCIT:C26733 {source="DOID:5656", source="MONDO:equivalentTo"} +xref: SCTID:73013002 {source="DOID:5656", source="MONDO:equivalentTo"} +xref: UMLS:C0010266 {source="DOID:5656", source="MONDO:equivalentTo", source="NCIT:C26733"} +is_a: MONDO:0005042 ! head disorder +is_a: MONDO:0005071 {source="DOID:5656/inferred", source="MESH:D003389", source="MONDO:Redundant", source="NCIT:C26733"} ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0034713 ! cranial neuron projection bundle +relationship: disease_has_location UBERON:0034713 ! cranial neuron projection bundle +property_value: exactMatch DOID:5656 +property_value: exactMatch http://identifiers.org/mesh/D003389 +property_value: exactMatch http://identifiers.org/snomedct/73013002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010266 +property_value: exactMatch NCIT:C26733 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003574 +name: external ear cancer +def: "A malignant neoplasm involving the external ear." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of external ear" EXACT [MONDO:patterns/cancer] +synonym: "external ear cancer" EXACT [MONDO:patterns/location] +synonym: "malignant external Ear neoplasm" EXACT [NCIT:C4653] +synonym: "malignant external ear neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant external Ear tumor" EXACT [NCIT:C4653] +synonym: "malignant neoplasm of external Ear" EXACT [NCIT:C4653] +synonym: "malignant neoplasm of external ear" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the external Ear" EXACT [NCIT:C4653] +synonym: "malignant neoplasm of the external ear" EXACT [DOID:5665, NCIT:C4653] +synonym: "malignant tumor of external Ear" EXACT [NCIT:C4653] +synonym: "malignant tumor of the external Ear" EXACT [NCIT:C4653] +xref: DOID:5665 {source="MONDO:equivalentTo"} +xref: NCIT:C4653 {source="DOID:5665", source="MONDO:equivalentTo"} +xref: SCTID:277156006 {source="DOID:5665", source="MONDO:equivalentTo"} +xref: UMLS:C0349576 {source="DOID:5665", source="MONDO:equivalentTo", source="NCIT:C4653"} +is_a: MONDO:0003277 {source="MONDO:Redundant", source="NCIT:C4653"} ! malignant ear neoplasm +is_a: MONDO:0004532 ! auditory system cancer +is_a: MONDO:0021235 {source="MONDO:Redundant", source="NCIT:C4653"} ! external ear neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch DOID:5665 +property_value: exactMatch http://identifiers.org/snomedct/277156006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349576 +property_value: exactMatch NCIT:C4653 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003579 +name: retinal nerve fibre layer disorder +def: "A disease that involves the nerve fiber layer of retina." [MONDO:patterns/location] +synonym: "disease of nerve fiber layer of retina" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of nerve fiber layer of retina" EXACT [] +synonym: "disorder of nerve fiber layer of retina" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "nerve fiber layer of retina disease" EXACT [MONDO:design_pattern] +synonym: "nerve fiber layer of retina disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "nerve fibre bundle defect" RELATED [DOID:5678] +synonym: "retinal nerve fiber bundle defects" EXACT [DOID:5678, ICD9CM:362.85] +synonym: "retinal nerve fiber bundle deficiency" EXACT [DOID:5678] +xref: DOID:5678 {source="MONDO:equivalentTo"} +xref: ICD9:362.85 {source="DOID:5678"} +xref: SCTID:193428001 {source="MONDO:equivalentTo"} +xref: UMLS:C3665426 {source="MONDO:equivalentTo"} +is_a: MONDO:0001834 {source="DOID:5678"} ! visual pathway disorder +is_a: MONDO:0005283 {source="DOID:5678", source="MONDO:Redundant"} ! retinal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001793 ! nerve fiber layer of retina +relationship: disease_has_location UBERON:0001793 ! nerve fiber layer of retina +property_value: exactMatch DOID:5678 +property_value: exactMatch http://identifiers.org/snomedct/193428001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3665426 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003606 +name: adrenal medulla cancer +def: "A malignant neoplasm involving the adrenal medulla" [https://orcid.org/0000-0002-6601-2165] +subset: gard_rare {source="GARD:0005755"} +synonym: "adrenal medulla cancer" EXACT [MONDO:patterns/location] +synonym: "adrenal medulla neoplasm" BROAD [DOID:5719] +synonym: "adrenal medulla tumor" BROAD [DOID:5719] +synonym: "cancer of adrenal medulla" EXACT [MONDO:patterns/cancer] +synonym: "malignant adrenal medulla neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4396] +synonym: "malignant adrenal medulla tumor" EXACT [NCIT:C4396] +synonym: "malignant neoplasm of adrenal medulla" EXACT [DOID:5719, MONDO:patterns/cancer, NCIT:C4396] +synonym: "malignant neoplasm of the adrenal medulla" EXACT [NCIT:C4396] +synonym: "malignant tumor of adrenal medulla" EXACT [NCIT:C4396] +synonym: "malignant tumor of the adrenal medulla" EXACT [DOID:5719, NCIT:C4396] +xref: DOID:5719 {source="MONDO:equivalentTo"} +xref: GARD:0005755 {source="MONDO:equivalentTo"} +xref: NCIT:C4396 {source="MONDO:equivalentTo", source="DOID:5719"} +xref: SCTID:371965009 {source="MONDO:equivalentTo", source="DOID:5719"} +xref: UMLS:C0344456 {source="NCIT:C4396", source="MONDO:equivalentTo", source="DOID:5719"} +is_a: MONDO:0002817 {source="DOID:5719", source="MONDO:Redundant", source="NCIT:C4396"} ! adrenal gland cancer +is_a: MONDO:0021237 {source="MONDO:Redundant", source="NCIT:C4396"} ! adrenal medulla neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001236 ! adrenal medulla +property_value: exactMatch DOID:5719 +property_value: exactMatch http://identifiers.org/snomedct/371965009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0344456 +property_value: exactMatch NCIT:C4396 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5755/adrenal-medulla-cancer xsd:anyURI {source="GARD:0005755"} + +[Term] +id: MONDO:0003607 +name: neuritis of upper limb +def: "A neuritis that involves the forelimb." [MONDO:patterns/location] +synonym: "forelimb neuritis" EXACT [MONDO:patterns/location] +synonym: "neuritis of forelimb" EXACT [] +xref: DOID:572 {source="MONDO:equivalentTo"} +xref: ICD9:354 {source="DOID:572"} +is_a: MONDO:0002122 ! neuritis +intersection_of: MONDO:0002122 ! neuritis +intersection_of: disease_has_location UBERON:0002102 ! forelimb +relationship: disease_has_location UBERON:0002102 ! forelimb +property_value: exactMatch DOID:572 +property_value: excluded_subClassOf MONDO:0002121 {source="DOID:572"} + +[Term] +id: MONDO:0003612 +name: uterine ligament cancer +def: "A primary or metastatic malignant neoplasm that affects the uterine ligament." [NCIT:C126498] +synonym: "cancer of uterine ligament" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of uterine ligament" EXACT [MONDO:patterns/cancer] +synonym: "malignant uterine ligament neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C126498] +synonym: "uterine ligament cancer" EXACT [MONDO:patterns/location] +xref: DOID:5727 {source="MONDO:equivalentTo"} +xref: NCIT:C126498 {source="MONDO:equivalentTo"} +xref: UMLS:C0864950 {source="MONDO:equivalentTo", source="NCIT:C126498"} +is_a: MONDO:0000637 ! musculoskeletal system cancer +is_a: MONDO:0002974 ! cervical cancer +is_a: MONDO:0021629 {source="MONDO:Redundant", source="NCIT:C126498"} ! uterine ligament neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0036262 ! uterine ligament +property_value: exactMatch DOID:5727 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0864950 +property_value: exactMatch NCIT:C126498 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003617 +name: chronic salpingitis +def: "Chronic inflammation of the fallopian tube. It usually follows an acute inflammatory attack." [NCIT:P378] +synonym: "salpingitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:5731 {source="MONDO:equivalentTo"} +xref: ICD10CM:N70.11 {source="DOID:5731", source="MONDO:equivalentTo"} +xref: NCIT:C40118 {source="DOID:5731", source="MONDO:equivalentTo"} +xref: SCTID:55551005 {source="DOID:5731", source="MONDO:equivalentTo"} +xref: UMLS:C0269041 {source="DOID:5731", source="NCIT:C40118", source="MONDO:equivalentTo"} +is_a: MONDO:0003619 {source="DOID:5731", source="MONDO:Redundant", source="NCIT:C40118"} ! salpingitis +intersection_of: MONDO:0003619 ! salpingitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:5731 +property_value: exactMatch http://identifiers.org/snomedct/55551005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0269041 +property_value: exactMatch https://icd.codes/icd10cm/N70.11 +property_value: exactMatch NCIT:C40118 + +[Term] +id: MONDO:0003619 +name: salpingitis +def: "Acute or chronic inflammation of the fallopian tube. It is most often caused by Neisseria gonorrhoeae and Chlamydia trachomatis infections. The infections usually originate in the vagina and ascend to the fallopian tube. Symptoms include abdominal, pelvic, and lower back pain, pain during ovulation and sexual intercourse, fever, nausea, and vomiting. Complications include infertility and ectopic pregnancy." [NCIT:P378] +synonym: "fallopian tube inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of fallopian tube" EXACT [] +xref: DOID:5733 {source="MONDO:equivalentTo"} +xref: MESH:D012488 {source="DOID:5733", source="MONDO:equivalentTo"} +xref: NCIT:C26880 {source="DOID:5733", source="MONDO:equivalentTo"} +xref: SCTID:88157006 {source="DOID:5733", source="MONDO:equivalentTo"} +xref: UMLS:C0036130 {source="NCIT:C26880", source="DOID:5733", source="MONDO:equivalentTo"} +is_a: MONDO:0000922 ! pelvic inflammatory disease +is_a: MONDO:0002156 {source="DOID:5733", source="MESH:D012488", source="MONDO:Redundant", source="NCIT:C26880/inferred"} ! fallopian tube disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0003889 ! fallopian tube +relationship: disease_has_inflammation_site UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:5733 +property_value: exactMatch http://identifiers.org/mesh/D012488 +property_value: exactMatch http://identifiers.org/snomedct/88157006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036130 +property_value: exactMatch NCIT:C26880 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003620 +name: peripheral nervous system disorder +def: "A disease involving the peripheral nervous system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of peripheral nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of peripheral nervous system" EXACT [] +synonym: "disorder of peripheral nervous system" EXACT [MONDO:patterns/location_top, NCIT:C27580] +synonym: "disorder of the peripheral nervous system" EXACT [] +synonym: "nerve disease, peripheral" NARROW [MESH:D010523] +synonym: "nerve diseases, peripheral" NARROW [MESH:D010523] +synonym: "neuropathy, peripheral" NARROW [MESH:D010523] +synonym: "peripheral nerve disease" NARROW [DOID:574, MESH:D010523, MTH:516, NCIT:C27580] +synonym: "peripheral nerve diseases" NARROW [MESH:D010523] +synonym: "peripheral nervous system disease" EXACT [MESH:D010523, MONDO:patterns/location, NCIT:C27580] +synonym: "peripheral nervous system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "peripheral nervous system disorder" EXACT [NCIT:C27580] +synonym: "peripheral nervous system disorders" EXACT [MESH:D010523] +synonym: "peripheral Neuropathies" NARROW [MESH:D010523] +synonym: "peripheral neuropathy" NARROW [DOID:574, MESH:D010523] +synonym: "PNS (peripheral nervous system) diseases" EXACT [MESH:D010523] +synonym: "PNS disease" EXACT [MESH:D010523] +synonym: "PNS diseases" EXACT [MESH:D010523] +xref: DOID:574 {source="MONDO:equivalentTo"} +xref: ICD9:350-359.99 {source="DOID:574"} +xref: ICD9:356.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010523 {source="MONDO:equivalentTo", source="DOID:574"} +xref: NCIT:C27580 {source="MONDO:equivalentTo", source="DOID:574"} +xref: SCTID:42658009 {source="MONDO:equivalentTo", source="DOID:574"} +is_a: MONDO:0005071 {source="DOID:574", source="MESH:D010523/inferred", source="MONDO:Redundant", source="NCIT:C27580"} ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000010 ! peripheral nervous system +relationship: disease_has_location UBERON:0000010 ! peripheral nervous system +property_value: exactMatch DOID:574 +property_value: exactMatch http://identifiers.org/mesh/D010523 +property_value: exactMatch http://identifiers.org/snomedct/42658009 +property_value: exactMatch NCIT:C27580 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003624 +name: acinic cell breast carcinoma +def: "A breast adenocarcinoma characterized by the presence of serous (acinic cell) differentiation." [NCIT:C40367] +synonym: "acinar cell breast carcinoma" EXACT [MONDO:patterns/location] +synonym: "acinic cell breast carcinoma" EXACT [NCIT:C40367] +synonym: "breast carcinoma of acinar cell" EXACT [MONDO:design_pattern] +xref: DOID:5743 {source="MONDO:equivalentTo"} +xref: NCIT:C40367 {source="DOID:5743", source="MONDO:equivalentTo"} +xref: UMLS:C1515868 {source="DOID:5743", source="MONDO:equivalentTo", source="NCIT:C40367"} +is_a: MONDO:0004953 ! invasive ductal breast carcinoma +is_a: MONDO:0004965 {source="DOID:5743", source="MONDO:Redundant", source="NCIT:C40367"} ! acinar cell carcinoma +intersection_of: MONDO:0004989 ! breast carcinoma +intersection_of: disease_has_location CL:0000622 ! acinar cell +property_value: exactMatch DOID:5743 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1515868 +property_value: exactMatch NCIT:C40367 + +[Term] +id: MONDO:0003627 +name: rheumatic pulmonary valve disease +def: "A rheumatologic disorder that involves the pulmonary valve." [MONDO:patterns/location] +synonym: "pulmonary valve rheumatologic disorder" EXACT [MONDO:patterns/location] +synonym: "rheumatic disease of pulmonary valve" EXACT [DOID:5748, ICD9CM:397.1] +synonym: "rheumatic pulmonary incompetence" EXACT [DOID:5748] +synonym: "rheumatologic disorder of pulmonary valve" EXACT [MONDO:design_pattern] +xref: DOID:5748 {source="MONDO:equivalentTo"} +xref: ICD9:397.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5748"} +xref: SCTID:18687009 {source="MONDO:equivalentTo", source="DOID:5748"} +xref: UMLS:C0155579 {source="MONDO:equivalentTo", source="DOID:5748"} +is_a: MONDO:0000603 {source="DOID:5748", source="MONDO:Entailed"} ! autoimmune disorder of cardiovascular system +is_a: MONDO:0003628 {source="DOID:5748", source="MONDO:Redundant"} ! pulmonary valve disorder +is_a: MONDO:0005554 {source="DOID:5748", source="MONDO:Redundant"} ! rheumatic disorder +intersection_of: MONDO:0005554 ! rheumatic disorder +intersection_of: disease_has_location UBERON:0002146 ! pulmonary valve +property_value: exactMatch DOID:5748 +property_value: exactMatch http://identifiers.org/snomedct/18687009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155579 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0003628 +name: pulmonary valve disorder +def: "A disease involving the pulmonary valve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of pulmonary valve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pulmonary valve" EXACT [] +synonym: "disorder of pulmonary valve" EXACT [MONDO:patterns/location_top] +synonym: "pulmonary valve disease" EXACT [MONDO:patterns/location] +synonym: "pulmonary valve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "pulmonary valve disorder" EXACT [DOID:5749, ICD9CM:424.3] +xref: DOID:5749 {source="MONDO:equivalentTo"} +xref: ICD9:424.3 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5749"} +xref: NCIT:C78579 {source="MONDO:equivalentTo", source="DOID:5749"} +xref: SCTID:76267008 {source="MONDO:equivalentTo", source="DOID:5749"} +xref: UMLS:C0034087 {source="MONDO:equivalentTo", source="DOID:5749", source="NCIT:C78579"} +is_a: MONDO:0002869 {source="DOID:5749", source="MONDO:Redundant", source="NCIT:C78579"} ! heart valve disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002146 ! pulmonary valve +relationship: disease_has_location UBERON:0002146 ! pulmonary valve +property_value: exactMatch DOID:5749 +property_value: exactMatch http://identifiers.org/snomedct/76267008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034087 +property_value: exactMatch NCIT:C78579 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003632 +name: endocervicitis +def: "Inflammation of the endocervix." [NCIT:P378] +synonym: "endocervix inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of endocervix" EXACT [] +xref: DOID:5757 {source="MONDO:equivalentTo"} +xref: NCIT:C26762 {source="DOID:5757", source="MONDO:equivalentTo"} +xref: SCTID:31354001 {source="DOID:5757", source="MONDO:equivalentTo"} +xref: UMLS:C0014127 {source="NCIT:C26762", source="DOID:5757", source="MONDO:equivalentTo"} +is_a: MONDO:0002345 {source="DOID:5757", source="NCIT:C26762"} ! cervicitis +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000458 ! endocervix +relationship: disease_has_inflammation_site UBERON:0000458 ! endocervix +property_value: exactMatch DOID:5757 +property_value: exactMatch http://identifiers.org/snomedct/31354001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014127 +property_value: exactMatch NCIT:C26762 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003635 +name: sebaceous breast carcinoma +def: "A very rare breast adenocarcinoma with sebaceous differentiation." [NCIT:C40369] +synonym: "breast sebaceous adenocarcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "sebaceous adenocarcinoma of breast" EXACT [MONDO:design_pattern] +synonym: "sebaceous breast carcinoma" EXACT [NCIT:C40369] +xref: DOID:5760 {source="MONDO:equivalentTo"} +xref: NCIT:C40369 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:5760"} +xref: UMLS:C1519207 {source="NCIT:C40369", source="MONDO:equivalentTo", source="DOID:5760"} +is_a: MONDO:0004988 {source="MONDO:Redundant", source="NCIT:C40369"} ! breast adenocarcinoma +is_a: MONDO:0006256 {source="NCIT:C40369"} ! invasive breast carcinoma +is_a: MONDO:0006962 {source="MONDO:Redundant", source="NCIT:C40369"} ! sebaceous adenocarcinoma +intersection_of: MONDO:0006962 ! sebaceous adenocarcinoma +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:5760 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519207 +property_value: exactMatch NCIT:C40369 + +[Term] +id: MONDO:0003636 +name: vulvar sebaceous carcinoma +def: "A carcinoma that arises from the vulva. It is characterized by the presence of malignant basaloid glandular epithelial cells that resemble sebaceous epithelium and are arranged in cords and nests." [NCIT:C40309] +synonym: "mammalian vulva sebaceous adenocarcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "sebaceous adenocarcinoma of mammalian vulva" EXACT [MONDO:design_pattern] +xref: DOID:5761 {source="MONDO:equivalentTo"} +xref: NCIT:C40309 {source="DOID:5761", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1520094 {source="DOID:5761", source="MONDO:equivalentTo", source="NCIT:C40309"} +is_a: MONDO:0006962 ! sebaceous adenocarcinoma +is_a: MONDO:0024336 ! vulvar adenocarcinoma +intersection_of: MONDO:0006962 ! sebaceous adenocarcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:5761 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1520094 +property_value: exactMatch NCIT:C40309 + +[Term] +id: MONDO:0003638 +name: lung meningioma +def: "A primary or metastatic meningioma that is present in the lung. The lung is the most frequent site of metastasis of meningiomas." [NCIT:C5668] +synonym: "lung meningioma" EXACT [NCIT:C5668] +synonym: "lung meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "lung primary meningioma" EXACT [DOID:5764] +synonym: "meningioma (disease) of lung" EXACT [] +synonym: "meningioma of lung" EXACT [NCIT:C5668] +synonym: "meningioma of the lung" EXACT [NCIT:C5668] +synonym: "primary pulmonary meningioma" EXACT [DOID:5764, NCIT:C5276] +synonym: "pulmonary meningioma" EXACT [DOID:5764, NCIT:C5668] +xref: DOID:5764 {source="MONDO:equivalentTo"} +xref: NCIT:C5668 {source="DOID:5764", source="MONDO:equivalentTo"} +xref: UMLS:C1334450 {source="DOID:5764", source="MONDO:equivalentTo", source="NCIT:C5668"} +is_a: MONDO:0008903 {source="DOID:5764", source="MONDO:Entailed"} ! lung cancer +is_a: MONDO:0016642 {source="DOID:5764", source="MONDO:Redundant"} ! meningioma +is_a: MONDO:0021322 ! malignant tumor of meninges +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:5764 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334450 +property_value: exactMatch NCIT:C5668 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003641 +name: central nervous system hematopoietic neoplasm +def: "A primary or metastatic neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. Representative examples include Hodgkin and non-Hodgkin lymphomas, histiocytic tumors, and leukemias." [NCIT:C5503] +synonym: "central nervous system hematologic cancer" RELATED [DOID:5772] +synonym: "central nervous system hematopoietic and lymphoid system neoplasm" EXACT [MONDO:patterns/location] +synonym: "central nervous system hematopoietic neoplasm" EXACT [NCIT:C5503] +synonym: "central nervous system hematopoietic neoplasms" EXACT [NCIT:C5503] +synonym: "central nervous system hematopoietic tumor" EXACT [NCIT:C5503] +synonym: "CNS hematopoietic neoplasm" EXACT [NCIT:C5503] +synonym: "CNS hematopoietic tumor" EXACT [DOID:5772, NCIT:C5503] +synonym: "hematopoietic and lymphoid system neoplasm of central nervous system" EXACT [MONDO:design_pattern] +synonym: "hematopoietic neoplasm of central nervous system" EXACT [DOID:5772, NCIT:C5503] +synonym: "hematopoietic neoplasm of CNS" EXACT [NCIT:C5503] +synonym: "hematopoietic neoplasm of the central nervous system" EXACT [NCIT:C5503] +synonym: "hematopoietic neoplasm of the CNS" EXACT [NCIT:C5503] +synonym: "hematopoietic tumor of central nervous system" EXACT [NCIT:C5503] +synonym: "hematopoietic tumor of the central nervous system" EXACT [NCIT:C5503] +synonym: "lymphomas and hemopoietic neoplasms of CNS" EXACT [NCIT:C5503] +synonym: "lymphomas and hemopoietic neoplasms of the CNS" EXACT [NCIT:C5503] +xref: DOID:5772 {source="MONDO:equivalentTo"} +xref: NCIT:C5503 {source="DOID:5772", source="MONDO:equivalentTo"} +xref: UMLS:C1332882 {source="DOID:5772", source="MONDO:equivalentTo", source="NCIT:C5503"} +is_a: MONDO:0006130 {source="MONDO:Redundant", source="NCIT:C5503"} ! central nervous system neoplasm +is_a: MONDO:0044881 {source="NCIT:C5503"} ! hematopoietic and lymphoid cell neoplasm +intersection_of: MONDO:0002334 ! hematopoietic and lymphoid system neoplasm +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:5772 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332882 +property_value: exactMatch NCIT:C5503 +property_value: excluded_subClassOf MONDO:0002714 {source="DOID:5772"} + +[Term] +id: MONDO:0003646 +name: rectum neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the rectum. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5698] +synonym: "NET of the rectum" EXACT [Orphanet:100081] +synonym: "neuroendocrine neoplasm of rectum" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5698] +synonym: "neuroendocrine neoplasm of the rectum" EXACT [NCIT:C5698] +synonym: "neuroendocrine tumor of rectum" EXACT [DOID:5777, NCIT:C5698] +synonym: "rectal NET" EXACT [Orphanet:100081] +synonym: "rectal neuroendocrine neoplasm" EXACT [NCIT:C5698] +synonym: "rectum NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "rectum neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "rectum neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "rectum neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: DOID:5777 {source="MONDO:equivalentTo"} +xref: NCIT:C5698 {source="DOID:5777", source="MONDO:equivalentTo"} +xref: Orphanet:100081 {source="MONDO:equivalentTo"} +xref: UMLS:C1335686 {source="DOID:5777", source="MONDO:equivalentTo", source="NCIT:C5698"} +is_a: MONDO:0002883 {source="DOID:5777", source="MONDO:Redundant", source="NCIT:C5698/inferred"} ! intestinal neuroendocrine neoplasm +is_a: MONDO:0024476 {source="Orphanet:100081"} ! epithelial neoplasm of rectum +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum +relationship: has_modifier MONDO:0021136 {source="MONDO:0018514"} ! rare +property_value: exactMatch DOID:5777 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335686 +property_value: exactMatch NCIT:C5698 +property_value: exactMatch Orphanet:100081 +property_value: excluded_subClassOf MONDO:0006519 {source="DOID:5777"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0003648 +name: tympanic membrane disorder +def: "A disease involving the tympanic membrane." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of tympanic membrane" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of tympanic membrane" EXACT [] +synonym: "disorder of tympanic membrane" EXACT [MONDO:patterns/location_top] +synonym: "tympanic membrane disease" EXACT [MONDO:patterns/location] +synonym: "tympanic membrane disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:5782 {source="MONDO:equivalentTo"} +xref: ICD9:384.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5782"} +xref: SCTID:21426000 {source="MONDO:equivalentTo", source="DOID:5782"} +xref: UMLS:C0041825 {source="MONDO:equivalentTo", source="DOID:5782"} +is_a: MONDO:0003276 {source="DOID:5782", source="MONDO:Redundant"} ! middle ear disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002364 ! tympanic membrane +relationship: disease_has_location UBERON:0002364 ! tympanic membrane +property_value: exactMatch DOID:5782 +property_value: exactMatch http://identifiers.org/snomedct/21426000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0041825 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003649 +name: esophageal neuroendocrine tumor +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the esophagus." [NCIT:P378] +subset: ordo_disease +synonym: "esophageal NEN" EXACT [Orphanet:506136] +synonym: "esophageal NET" EXACT [NCIT:C95616] +synonym: "esophageal neuroendocrine neoplasm" EXACT [Orphanet:506136] +synonym: "esophageal neuroendocrine tumor" EXACT [NCIT:C95616] +synonym: "esophageal well differentiated endocrine tumor" EXACT [NCIT:C95616] +synonym: "esophageal well differentiated endocrine tumor/carcinoma" EXACT [NCIT:C95616] +synonym: "esophagus NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "esophagus neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "esophagus neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "esophagus neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "NEN of esophagus" EXACT [Orphanet:506136] +synonym: "neuroendocrine neoplasm of esophagus" EXACT [MONDO:patterns/neuroendocrine_neoplasm, Orphanet:506136] +synonym: "neuroendocrine tumor of esophagus" EXACT [DOID:5784, NCIT:C5821] +xref: DOID:5784 {source="MONDO:equivalentTo"} +xref: NCIT:C95616 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:506136 {source="MONDO:equivalentTo"} +xref: UMLS:C1333462 {source="DOID:5784", source="MONDO:equivalentTo"} +xref: UMLS:C2987260 {source="NCIT:C95616", source="MONDO:equivalentTo"} +is_a: MONDO:0000386 {source="NCIT:C95616"} ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0021355 {source="MONDO:Redundant", source="NCIT:C95616/inferred"} ! neoplasm of esophagus +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch DOID:5784 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333462 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2987260 +property_value: exactMatch NCIT:C95616 +property_value: exactMatch Orphanet:506136 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0003659 +name: pediatric lymphoma +def: "A Hodgkin or non-Hodgkin lymphoma that occurs during childhood." [NCIT:P378] +synonym: "childhood lymphoma" EXACT [NCIT:C5165] +synonym: "lymphoma" BROAD [NCIT:C5165] +synonym: "pediatric lymphoma" EXACT [NCIT:C5165] +xref: DOID:5823 {source="MONDO:equivalentTo"} +xref: NCIT:C5165 {source="DOID:5823", source="MONDO:equivalentTo"} +xref: UMLS:C1332979 {source="NCIT:C5165", source="DOID:5823", source="MONDO:equivalentTo"} +is_a: MONDO:0005062 {source="DOID:5823", source="NCIT:C5165"} ! lymphoma +is_a: MONDO:0006517 {source="NCIT:C5165"} ! childhood malignant neoplasm +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:5823 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332979 +property_value: exactMatch NCIT:C5165 + +[Term] +id: MONDO:0003661 +name: breast lymphoma +def: "A lymphoma that arises from the breast. There is no history of extramammary breast lymphoma and ipsilateral axillary lymph node involvement does not exclude the diagnosis of primary breast lymphoma. Most patients present with a painless breast lump. The vast majority of cases are B-cell non-Hodgkin lymphomas. Diffuse large B-cell lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue are the most common types of primary non-Hodgkin lymphoma of the breast. Primary Hodgkin lymphoma of the breast is rare." [NCIT:P378] +synonym: "breast lymphoma" EXACT [MONDO:patterns/location, NCIT:C4671] +synonym: "lymphoma of breast" EXACT [DOID:5826, NCIT:C4671] +synonym: "lymphoma of the breast" EXACT [DOID:5826, NCIT:C4671] +synonym: "malignant lymphoma of breast" EXACT [DOID:5826] +synonym: "primary breast lymphoma" EXACT [NCIT:C4671] +xref: DOID:5826 {source="MONDO:equivalentTo"} +xref: NCIT:C4671 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:278052009 {source="MONDO:equivalentTo", source="DOID:5826"} +xref: UMLS:C0349669 {source="NCIT:C4671", source="MONDO:equivalentTo", source="DOID:5826"} +xref: UMLS:C1704251 {source="MONDO:equivalentTo"} +is_a: MONDO:0005062 {source="DOID:5826", source="MONDO:Redundant", source="NCIT:C4671/inferred"} ! lymphoma +is_a: MONDO:0007254 {source="DOID:5826", source="MONDO:Redundant", source="NCIT:C4671"} ! breast cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:5826 +property_value: exactMatch http://identifiers.org/snomedct/278052009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349669 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1704251 +property_value: exactMatch NCIT:C4671 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0003663 +name: uterine ligament endometrioid adenocarcinoma +def: "A rare endometrioid adenocarcinoma that arises from the uterine ligament. Some of the reported cases were associated with endometriosis." [NCIT:C40138] +synonym: "endometrioid adenocarcinoma of uterine ligament" EXACT [MONDO:design_pattern] +synonym: "uterine ligament endometrioid adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C40138] +xref: DOID:5829 {source="MONDO:equivalentTo"} +xref: NCIT:C40138 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:5829"} +xref: UMLS:C1519868 {source="NCIT:C40138", source="MONDO:equivalentTo", source="DOID:5829"} +is_a: MONDO:0002741 {source="DOID:5829", source="MONDO:Redundant", source="NCIT:C40138"} ! uterine ligament adenocarcinoma +is_a: MONDO:0003665 ! cervical endometrioid adenocarcinoma +intersection_of: MONDO:0005026 ! endometrioid adenocarcinoma +intersection_of: disease_has_location UBERON:0036262 ! uterine ligament +property_value: exactMatch DOID:5829 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519868 +property_value: exactMatch NCIT:C40138 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003665 +name: cervical endometrioid adenocarcinoma +def: "A cervical adenocarcinoma with the histologic characteristics of the endometrioid adenocarcinoma of the endometrium." [NCIT:C6343] +synonym: "cervical endometrioid adenocarcinoma" EXACT [NCIT:C6343] +synonym: "cervical endometrioid carcinoma" EXACT [NCIT:C6343] +synonym: "cervix endometrioid adenocarcinoma" EXACT [NCIT:C6343] +synonym: "cervix endometrioid carcinoma" EXACT [NCIT:C6343] +synonym: "cervix uteri endometrioid adenocarcinoma" EXACT [NCIT:C6343] +synonym: "cervix uteri endometrioid carcinoma" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of cervix" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of cervix uteri" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of the cervix" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of the cervix uteri" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of the uterine cervix" EXACT [NCIT:C6343] +synonym: "endometrioid adenocarcinoma of uterine cervix" EXACT [NCIT:C6343] +synonym: "endometrioid carcinoma of cervix" EXACT [NCIT:C6343] +synonym: "endometrioid carcinoma of cervix uteri" EXACT [NCIT:C6343] +synonym: "endometrioid carcinoma of the cervix" EXACT [NCIT:C6343] +synonym: "endometrioid carcinoma of the cervix uteri" EXACT [DOID:5830, NCIT:C6343] +synonym: "endometrioid carcinoma of the uterine cervix" EXACT [NCIT:C6343] +synonym: "endometrioid carcinoma of uterine cervix" EXACT [NCIT:C6343] +synonym: "uterine cervix endometrioid adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6343] +synonym: "uterine cervix endometrioid carcinoma" EXACT [NCIT:C6343] +xref: DOID:5830 {source="MONDO:equivalentTo"} +xref: EFO:1000164 {source="MONDO:equivalentTo"} +xref: NCIT:C6343 {source="DOID:5830", source="EFO:1000164", source="MONDO:equivalentTo"} +xref: ONCOTREE:CEEN {source="MONDO:equivalentTo"} +xref: UMLS:C1332913 {source="DOID:5830", source="NCIT:C6343", source="MONDO:equivalentTo"} +is_a: MONDO:0005026 {source="MONDO:Redundant", source="NCIT:C6343"} ! endometrioid adenocarcinoma +is_a: MONDO:0005153 {source="DOID:5830", source="NCIT:C6343", source="ONCOTREE:CEEN"} ! cervical adenocarcinoma +intersection_of: MONDO:0005026 ! endometrioid adenocarcinoma +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +property_value: exactMatch DOID:5830 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332913 +property_value: exactMatch NCIT:C6343 + +[Term] +id: MONDO:0003666 +name: fallopian tube endometrioid adenocarcinoma +def: "An adenocarcinoma that arises from the fallopian tube and resembles the endometrioid adenocarcinoma of the uterus. It usually has a favorable prognosis." [NCIT:C6279] +synonym: "endometrioid adenocarcinoma of fallopian tube" EXACT [NCIT:C6279] +synonym: "endometrioid adenocarcinoma of the fallopian tube" EXACT [NCIT:C6279] +synonym: "endometrioid carcinoma of fallopian tube" EXACT [NCIT:C6279] +synonym: "endometrioid carcinoma of the fallopian tube" EXACT [DOID:5831, NCIT:C6279] +synonym: "fallopian tube endometrioid adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C6279] +synonym: "fallopian tube endometrioid cancer" EXACT [DOID:5831] +synonym: "fallopian tube endometrioid carcinoma" EXACT [NCIT:C6279] +synonym: "fallopian tube endometrioid neoplasm" RELATED [DOID:5831] +xref: DOID:5831 {source="MONDO:equivalentTo"} +xref: NCIT:C6279 {source="DOID:5831", source="MONDO:equivalentTo"} +xref: UMLS:C1333592 {source="DOID:5831", source="MONDO:equivalentTo", source="NCIT:C6279"} +is_a: MONDO:0002746 {source="DOID:5831", source="MONDO:Redundant", source="NCIT:C6279"} ! fallopian tube adenocarcinoma +is_a: MONDO:0005026 {source="MONDO:Redundant", source="NCIT:C6279"} ! endometrioid adenocarcinoma +intersection_of: MONDO:0005026 ! endometrioid adenocarcinoma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:5831 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333592 +property_value: exactMatch NCIT:C6279 + +[Term] +id: MONDO:0003685 +name: retroperitoneal germ cell neoplasm +def: "A germ cell tumor that involves the retroperitoneal space." [MONDO:patterns/location] +synonym: "germ cell neoplasm of retroperitoneum" EXACT [NCIT:C6447] +synonym: "germ cell neoplasm of the retroperitoneum" EXACT [NCIT:C6447] +synonym: "germ cell tumor of retroperitoneum" EXACT [DOID:5874, NCIT:C6447] +synonym: "germ cell tumor of the retroperitoneum" EXACT [NCIT:C6447] +synonym: "retroperitoneal germ cell tumor" EXACT [NCIT:C6447] +xref: DOID:5874 {source="MONDO:equivalentTo"} +xref: NCIT:C6447 {source="DOID:5874", source="MONDO:equivalentTo"} +xref: UMLS:C1335776 {source="DOID:5874", source="MONDO:equivalentTo", source="NCIT:C6447"} +is_a: MONDO:0005040 ! germ cell tumor +is_a: MONDO:0024645 ! retroperitoneal neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0003693 ! retroperitoneal space +property_value: exactMatch DOID:5874 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335776 +property_value: exactMatch NCIT:C6447 +property_value: excluded_subClassOf MONDO:0005941 {source="DOID:5874"} + +[Term] +id: MONDO:0003686 +name: apocrine sweat gland neoplasm +def: "A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma." [NCIT:P378] +synonym: "apocrine neoplasm" EXACT [NCIT:C6798] +synonym: "apocrine neoplasm of skin" EXACT [NCIT:C6798] +synonym: "apocrine neoplasm of the skin" EXACT [NCIT:C6798] +synonym: "apocrine skin neoplasm" EXACT [NCIT:C6798] +synonym: "apocrine skin tumor" EXACT [NCIT:C6798] +synonym: "apocrine sweat gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "apocrine sweat gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "apocrine tumor" EXACT [DOID:5876, NCIT:C6798] +synonym: "apocrine tumor of skin" EXACT [NCIT:C6798] +synonym: "apocrine tumor of the skin" EXACT [NCIT:C6798] +synonym: "neoplasm of apocrine sweat gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of apocrine sweat gland" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5876 {source="MONDO:equivalentTo"} +xref: NCIT:C6798 {source="DOID:5876", source="MONDO:equivalentTo"} +xref: UMLS:C1332318 {source="DOID:5876", source="MONDO:equivalentTo"} +is_a: MONDO:0002381 {source="DOID:5876", source="MONDO:Redundant", source="NCIT:C6798"} ! sweat gland neoplasm +is_a: MONDO:0024467 ! apocrine sweat gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000382 ! apocrine sweat gland +property_value: exactMatch DOID:5876 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332318 +property_value: exactMatch NCIT:C6798 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003687 +name: endocardium cancer +def: "A malignant neoplasm involving the endocardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of endocardium" EXACT [MONDO:patterns/cancer] +synonym: "endocardium cancer" EXACT [MONDO:patterns/location] +synonym: "malignant endocardial neoplasm" EXACT [NCIT:C4570] +synonym: "malignant endocardial tumor" EXACT [DOID:5877, NCIT:C4570] +synonym: "malignant endocardium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of endocardium" EXACT [DOID:5877, MONDO:patterns/cancer, NCIT:C4570] +synonym: "malignant neoplasm of the endocardium" EXACT [NCIT:C4570] +synonym: "malignant tumor of endocardium" EXACT [DOID:5877, NCIT:C4570] +synonym: "malignant tumor of the endocardium" EXACT [NCIT:C4570] +xref: DOID:5877 {source="MONDO:equivalentTo"} +xref: NCIT:C4570 {source="MONDO:equivalentTo", source="DOID:5877"} +xref: SCTID:363436001 {source="MONDO:equivalentTo", source="DOID:5877"} +xref: UMLS:C0346612 {source="NCIT:C4570", source="MONDO:equivalentTo", source="DOID:5877"} +is_a: MONDO:0001340 {source="DOID:5877", source="MONDO:Redundant", source="NCIT:C4570"} ! heart cancer +is_a: MONDO:0021378 {source="MONDO:Redundant", source="NCIT:C4570"} ! neoplasm of endocardium +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002165 ! endocardium +property_value: exactMatch DOID:5877 +property_value: exactMatch http://identifiers.org/snomedct/363436001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346612 +property_value: exactMatch NCIT:C4570 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003700 +name: brachial plexus neoplasm +def: "A neoplasm (disease) that involves the brachial nerve plexus." [MONDO:patterns/location] +synonym: "brachial nerve plexus neoplasm" EXACT [] +synonym: "brachial nerve plexus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "brachial nerve plexus tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "brachial plexus neoplasm" EXACT [NCIT:C5823] +synonym: "brachial plexus neoplasms" EXACT [NCIT:C5823] +synonym: "brachial plexus tumor" EXACT [NCIT:C5823] +synonym: "neoplasm of brachial nerve plexus" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of brachial plexus" EXACT [NCIT:C5823] +synonym: "neoplasm of the brachial plexus" EXACT [NCIT:C5823] +synonym: "tumor of brachial nerve plexus" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of brachial plexus" EXACT [NCIT:C5823] +synonym: "tumor of the brachial plexus" EXACT [DOID:5913, NCIT:C5823] +xref: DOID:5913 {source="MONDO:equivalentTo"} +xref: NCIT:C5823 {source="MONDO:equivalentTo", source="DOID:5913", source="MONDO:exact-label-match"} +xref: UMLS:C1332602 {source="MONDO:equivalentTo", source="DOID:5913", source="NCIT:C5823"} +is_a: MONDO:0003100 {source="DOID:5913", source="MONDO:Redundant", source="NCIT:C5823"} ! nerve plexus neoplasm +is_a: MONDO:0006683 ! brachial plexus neuropathy +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001814 ! brachial nerve plexus +property_value: exactMatch DOID:5913 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332602 +property_value: exactMatch NCIT:C5823 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003714 +name: bladder urachal squamous cell carcinoma +synonym: "bladder urachal squamous cell carcinoma" EXACT [NCIT:C39845] +xref: DOID:5957 {source="MONDO:equivalentTo"} +xref: NCIT:C39845 {source="MONDO:equivalentTo", source="DOID:5957", source="MONDO:exact-label-match"} +xref: UMLS:C1511206 {source="MONDO:equivalentTo", source="DOID:5957", source="NCIT:C39845"} +is_a: MONDO:0002760 {source="MONDO:Redundant", source="NCIT:C39845"} ! bladder squamous cell carcinoma +is_a: MONDO:0003715 {source="DOID:5957", source="MONDO:Redundant", source="NCIT:C39845"} ! bladder urachal carcinoma +intersection_of: MONDO:0002760 ! bladder squamous cell carcinoma +intersection_of: disease_arises_from_structure UBERON:0011202 ! urachus epithelium +property_value: exactMatch DOID:5957 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511206 +property_value: exactMatch NCIT:C39845 + +[Term] +id: MONDO:0003715 +name: bladder urachal carcinoma +def: "Urachal cancer is a type of bladder cancer, making up less than 1% of all bladder cancers. The urachus is a structure normally only present during development in the womb that connects the bellybutton and the bladder. This connection normally disappears before birth, but in some people remains. Urachalcancers are usually diagnosed in adults in their 50's and 60's and may develop at the dome or anterior wall of the bladder, along the midline of the body (including the belly button), and between the pubis symphasis and the bladder.Most urachal cancersare adenocarcinomas (cancers that develop from gland cells).Others may besarcomas (which develop from connective tissue -such as leiomyosarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma), small cell carcinomas, transitional cell cancer, and mixed neoplasias. Most individuals with urachal cancer have symptoms of with hematuria (blood in urine). Other symptoms may include abdominal pain, a palpable abdominal mass, mucinuria, and bacteriuria. Treatment usually involved surgery to remove the cancer." [GARD:0007836] +subset: gard_rare +synonym: "bladder urachal cancer" EXACT [NCIT:C39842] +synonym: "bladder urachal carcinoma" EXACT [NCIT:C39842] +synonym: "urachal carcinoma" RELATED [GARD:0007836, ONCOTREE:URCA] +xref: DOID:5958 {source="MONDO:equivalentTo"} +xref: GARD:0007836 {source="MONDO:equivalentTo"} +xref: MESH:C536475 {source="MONDO:equivalentTo"} +xref: NCIT:C39842 {source="MONDO:equivalentTo", source="DOID:5958", source="MONDO:exact-label-match"} +xref: ONCOTREE:URCA {source="MONDO:equivalentTo"} +xref: UMLS:C1511205 {source="MONDO:equivalentObsolete", source="NCIT:C39842", source="DOID:5958"} +is_a: MONDO:0004986 {source="DOID:5958", source="MONDO:Redundant", source="NCIT:C39842"} ! urinary bladder carcinoma +intersection_of: MONDO:0004986 ! urinary bladder carcinoma +intersection_of: disease_arises_from_structure UBERON:0011202 ! urachus epithelium +relationship: disease_arises_from_structure UBERON:0011202 ! urachus epithelium +property_value: exactMatch DOID:5958 +property_value: exactMatch http://identifiers.org/mesh/C536475 +property_value: exactMatch NCIT:C39842 + +[Term] +id: MONDO:0003719 +name: renal pelvis neoplasm +def: "A neoplasm (disease) that involves the renal pelvis." [MONDO:patterns/location] +synonym: "kidney pelvis neoplasm" EXACT [NCIT:C8404] +synonym: "kidney pelvis tumor" EXACT [NCIT:C8404] +synonym: "neoplasm of kidney pelvis" EXACT [NCIT:C8404] +synonym: "neoplasm of renal pelvis" EXACT [MONDO:patterns/neoplasm, NCIT:C8404] +synonym: "neoplasm of the kidney pelvis" EXACT [NCIT:C8404] +synonym: "neoplasm of the renal pelvis" EXACT [NCIT:C8404] +synonym: "renal pelvis neoplasm" EXACT [NCIT:C8404] +synonym: "renal pelvis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "renal pelvis tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C8404] +synonym: "tumor of kidney pelvis" EXACT [DOID:5977, NCIT:C8404] +synonym: "tumor of renal pelvis" EXACT [MONDO:patterns/neoplasm, NCIT:C8404] +synonym: "tumor of the kidney pelvis" EXACT [NCIT:C8404] +synonym: "tumor of the renal pelvis" EXACT [NCIT:C8404] +xref: DOID:5977 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C8404 {source="DOID:5977", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:126881002 {source="DOID:5977", source="MONDO:equivalentTo"} +xref: UMLS:C0346260 {source="DOID:5977", source="MONDO:equivalentTo", source="NCIT:C8404"} +is_a: MONDO:0021163 {source="MONDO:Redundant", source="NCIT:C8404"} ! kidney neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +relationship: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:5977 +property_value: exactMatch http://identifiers.org/snomedct/126881002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346260 +property_value: exactMatch NCIT:C8404 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0003722 +name: internal auditory canal meningioma +def: "A meningioma that affects the internal auditory canal." [NCIT:P378] +synonym: "internal acoustic meatus meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of internal acoustic meatus" EXACT [] +synonym: "meningioma of internal auditory canal" EXACT [NCIT:C5307] +synonym: "meningioma of the internal auditory canal" EXACT [DOID:5990, NCIT:C5307] +xref: DOID:5990 {source="MONDO:equivalentTo"} +xref: NCIT:C5307 {source="MONDO:equivalentTo", source="DOID:5990"} +xref: UMLS:C1334227 {source="MONDO:equivalentTo", source="NCIT:C5307", source="DOID:5990"} +is_a: MONDO:0003121 {source="NCIT:C5307"} ! middle cranial fossa meningioma +is_a: MONDO:0024320 ! inner ear neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0011859 ! internal acoustic meatus +relationship: disease_has_location UBERON:0011859 ! internal acoustic meatus +property_value: exactMatch DOID:5990 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334227 +property_value: exactMatch NCIT:C5307 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0002998 {source="NCIT:C5307"} +property_value: excluded_subClassOf MONDO:0004532 {source="DOID:5990"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003749 +name: esophageal disorder +def: "A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas." [NCIT:C3027] +synonym: "disease of esophagus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of esophagus" EXACT [] +synonym: "disorder of esophagus" EXACT [MONDO:patterns/location_top] +synonym: "esophageal disorder" EXACT [NCIT:C3027] +synonym: "esophageal ulcer" NARROW [DOID:6050, NCIT:C26950] +synonym: "esophagus disease" EXACT [MONDO:patterns/location] +synonym: "esophagus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:6050 {source="MONDO:equivalentTo"} +xref: ICD9:530 {source="DOID:6050"} +xref: ICD9:530.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:530.20 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:530.9 {source="DOID:6050"} +xref: MESH:D004935 {source="MONDO:equivalentTo", source="DOID:6050"} +xref: NCIT:C3027 {source="MONDO:equivalentTo", source="DOID:6050"} +xref: SCTID:30811009 {source="MONDO:equivalentTo"} +xref: SCTID:37657006 {source="MONDO:equivalentTo", source="DOID:6050"} +xref: UMLS:C0014852 {source="MONDO:equivalentTo", source="DOID:6050"} +is_a: MONDO:0004335 {source="DOID:6050", source="MESH:D004935", source="NCIT:C3027"} ! digestive system disorder +is_a: MONDO:0044991 ! upper digestive tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001043 ! esophagus +relationship: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch DOID:6050 +property_value: exactMatch http://identifiers.org/mesh/D004935 +property_value: exactMatch http://identifiers.org/snomedct/30811009 +property_value: exactMatch http://identifiers.org/snomedct/37657006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014852 +property_value: exactMatch NCIT:C3027 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003750 +name: childhood central nervous system germ cell tumor +def: "A germ cell tumor of the central nervous system occurring in children." [NCIT:C6205] +synonym: "central nervous system childhood germ cell tumor" EXACT [MONDO:patterns/location] +synonym: "central nervous system germ cell tumor" BROAD [NCIT:C6205] +synonym: "central nervous system pediatric germ cell cancer" EXACT [MONDO:patterns/location] +synonym: "childhood central nervous system germ cell neoplasm" EXACT [NCIT:C6205] +synonym: "childhood central nervous system germ cell tumor" EXACT [NCIT:C6205] +synonym: "childhood CNS germ cell neoplasm" EXACT [NCIT:C6205] +synonym: "childhood CNS germ cell tumor" EXACT [NCIT:C6205] +synonym: "childhood germ cell neoplasm of central nervous system" EXACT [NCIT:C6205] +synonym: "childhood germ cell neoplasm of CNS" EXACT [NCIT:C6205] +synonym: "childhood germ cell neoplasm of the central nervous system" EXACT [NCIT:C6205] +synonym: "childhood germ cell neoplasm of the CNS" EXACT [NCIT:C6205] +synonym: "childhood germ cell tumor of central nervous system" EXACT [NCIT:C6205] +synonym: "childhood germ cell tumor of CNS" EXACT [NCIT:C6205] +synonym: "childhood germ cell tumor of the central nervous system" EXACT [NCIT:C6205] +synonym: "childhood germ cell tumor of the CNS" EXACT [NCIT:C6205] +synonym: "pediatric central nervous system germ cell neoplasm" EXACT [NCIT:C6205] +synonym: "pediatric central nervous system germ cell tumor" EXACT [NCIT:C6205] +synonym: "pediatric CNS germ cell neoplasm" EXACT [NCIT:C6205] +synonym: "pediatric CNS germ cell tumor" EXACT [NCIT:C6205] +synonym: "pediatric germ cell neoplasm of central nervous system" EXACT [NCIT:C6205] +synonym: "pediatric germ cell neoplasm of CNS" EXACT [DOID:6052, NCIT:C6205] +synonym: "pediatric germ cell neoplasm of the central nervous system" EXACT [NCIT:C6205] +synonym: "pediatric germ cell neoplasm of the CNS" EXACT [NCIT:C6205] +synonym: "pediatric germ cell tumor of central nervous system" EXACT [NCIT:C6205] +synonym: "pediatric germ cell tumor of CNS" EXACT [NCIT:C6205] +synonym: "pediatric germ cell tumor of the central nervous system" EXACT [NCIT:C6205] +synonym: "pediatric germ cell tumor of the CNS" EXACT [NCIT:C6205] +xref: DOID:6052 {source="MONDO:equivalentTo"} +xref: NCIT:C6205 {source="MONDO:equivalentTo", source="DOID:6052"} +xref: UMLS:C0278754 {source="MONDO:equivalentTo", source="NCIT:C6205", source="DOID:6052"} +is_a: MONDO:0003000 {source="DOID:6052", source="MONDO:Redundant", source="NCIT:C6205"} ! central nervous system germ cell tumor +is_a: MONDO:0003751 {source="DOID:6052", source="MONDO:Redundant", source="NCIT:C6205"} ! childhood germ cell tumor +intersection_of: MONDO:0003751 ! childhood germ cell tumor +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:6052 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278754 +property_value: exactMatch NCIT:C6205 + +[Term] +id: MONDO:0003751 +name: childhood germ cell tumor +def: "A germ cell tumor that occurs during childhood." [NCIT:C7928] +synonym: "childhood germ cell neoplasm" EXACT [NCIT:C7928] +synonym: "childhood germ cell tumor" EXACT [NCIT:C7928] +synonym: "germ cell tumor" BROAD [NCIT:C7928] +synonym: "pediatric germ cell cancer" RELATED [DOID:6053] +synonym: "pediatric germ cell neoplasm" EXACT [DOID:6053, NCIT:C7928] +synonym: "pediatric germ cell tumor" EXACT [DOID:6053, NCIT:C7928] +xref: DOID:6053 {source="MONDO:equivalentTo"} +xref: NCIT:C7928 {source="MONDO:equivalentTo", source="DOID:6053"} +xref: UMLS:C0279014 {source="NCIT:C7928", source="MONDO:equivalentTo", source="DOID:6053"} +is_a: MONDO:0005040 {source="DOID:6053", source="MONDO:Redundant", source="NCIT:C7928"} ! germ cell tumor +is_a: MONDO:0021079 {source="MONDO:Redundant", source="NCIT:C7928"} ! childhood neoplasm +intersection_of: MONDO:0005040 {source="NCIT:C7928"} ! germ cell tumor +intersection_of: has_modifier HP:0011463 {source="NCIT:C7928"} ! Childhood onset +property_value: exactMatch DOID:6053 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279014 +property_value: exactMatch NCIT:C7928 + +[Term] +id: MONDO:0003758 +name: childhood testicular germ cell tumor +def: "A germ cell tumor that arises from the testis during childhood." [NCIT:C6552] +synonym: "childhood testicular germ cell neoplasm" EXACT [NCIT:C6552] +synonym: "childhood testicular germ cell tumor" EXACT [NCIT:C6552] +synonym: "pediatric testicular germ cell neoplasm" EXACT [DOID:6082, NCIT:C6552] +synonym: "pediatric testicular germ cell tumor" EXACT [MONDO:patterns/childhood, NCIT:C6552] +synonym: "testicular germ cell tumor" BROAD [NCIT:C6552] +synonym: "testicular germ cell tumor of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: DOID:6082 {source="MONDO:equivalentTo"} +xref: NCIT:C6552 {source="DOID:6082", source="MONDO:equivalentTo"} +xref: UMLS:C0796663 {source="DOID:6082", source="MONDO:equivalentTo"} +is_a: MONDO:0010108 {source="DOID:6082", source="MONDO:Redundant", source="NCIT:C6552"} ! testicular germ cell tumor +is_a: MONDO:0020577 ! childhood gonadal germ cell tumor +is_a: MONDO:0037250 ! childhood testicular neoplasm +intersection_of: MONDO:0010108 ! testicular germ cell tumor +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6082 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0796663 +property_value: exactMatch NCIT:C6552 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml + +[Term] +id: MONDO:0003760 +name: pediatric ovarian germ cell tumor +def: "A germ cell tumor that arises from the ovary and occurs in children." [NCIT:P378] +synonym: "childhood ovarian germ cell neoplasm" EXACT [NCIT:C8588] +synonym: "childhood ovarian germ cell tumor" EXACT [NCIT:C8588] +synonym: "ovarian germ cell tumor" BROAD [NCIT:C8588] +synonym: "ovarian germ cell tumor of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric ovarian germ cell neoplasm" EXACT [DOID:6084, NCIT:C8588] +synonym: "pediatric ovarian germ cell tumor" EXACT [MONDO:patterns/childhood, NCIT:C8588] +xref: DOID:6084 {source="MONDO:equivalentTo"} +xref: NCIT:C8588 {source="MONDO:equivalentTo", source="DOID:6084"} +xref: UMLS:C0796664 {source="NCIT:C8588", source="MONDO:equivalentTo", source="DOID:6084"} +is_a: MONDO:0003751 ! childhood germ cell tumor +is_a: MONDO:0011366 {source="DOID:6084", source="MONDO:Redundant", source="NCIT:C8588"} ! ovarian germ cell tumor +intersection_of: MONDO:0011366 ! ovarian germ cell tumor +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6084 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0796664 +property_value: exactMatch NCIT:C8588 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml + +[Term] +id: MONDO:0003762 +name: malignant leptomeningeal tumor +def: "A primary or metastatic malignant tumor involving the leptomeninges." [NCIT:C8506] +synonym: "cancer of leptomeninx" EXACT [MONDO:patterns/cancer] +synonym: "leptomeningeal cancer" RELATED [NCIT:C8506] +synonym: "leptomeninx cancer" EXACT [MONDO:patterns/location] +synonym: "malignant leptomeningeal neoplasm" EXACT [NCIT:C8506] +synonym: "malignant leptomeningeal tumor" EXACT [NCIT:C8506] +synonym: "malignant leptomeninx neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of leptomeninges" RELATED [NCIT:C8506] +synonym: "malignant neoplasm of leptomeninx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the leptomeninges" RELATED [NCIT:C8506] +synonym: "malignant tumor of leptomeninges" EXACT [DOID:6086, NCIT:C8506] +synonym: "malignant tumor of the leptomeninges" RELATED [NCIT:C8506] +xref: DOID:6086 {source="MONDO:equivalentTo"} +xref: NCIT:C8506 {source="MONDO:equivalentTo", source="DOID:6086", source="NCIT:C8506"} +xref: UMLS:C1334596 {source="MONDO:equivalentTo", source="DOID:6086", source="NCIT:C8506"} +is_a: MONDO:0016642 {source="DOID:6086"} ! meningioma +is_a: MONDO:0021322 {source="MONDO:Redundant", source="NCIT:C8506"} ! malignant tumor of meninges +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000391 ! leptomeninx +relationship: disease_has_location UBERON:0000391 ! leptomeninx +property_value: exactMatch DOID:6086 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334596 +property_value: exactMatch NCIT:C8506 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003766 +name: thalamic cancer +def: "A cancer involving a dorsal plus ventral thalamus." [MONDO:patterns/cancer] +synonym: "cancer of dorsal plus ventral thalamus" EXACT [MONDO:patterns/cancer] +synonym: "dorsal plus ventral thalamus cancer" EXACT [MONDO:patterns/location] +synonym: "malignant dorsal plus ventral thalamus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of dorsal plus ventral thalamus" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of thalamus" EXACT [DOID:6098, NCIT:C4576] +synonym: "malignant neoplasm of the thalamus" EXACT [NCIT:C4576] +synonym: "malignant thalamic neoplasm" EXACT [NCIT:C4576] +synonym: "malignant thalamic neoplasms" EXACT [NCIT:C4576] +synonym: "malignant thalamic tumor" EXACT [NCIT:C4576] +synonym: "malignant thalamic tumors" EXACT [NCIT:C4576] +synonym: "malignant thalamus neoplasm" EXACT [NCIT:C4576] +synonym: "malignant thalamus neoplasms" EXACT [NCIT:C4576] +synonym: "malignant thalamus tumor" EXACT [NCIT:C4576] +synonym: "malignant thalamus tumors" EXACT [NCIT:C4576] +synonym: "malignant tumor of thalamus" EXACT [DOID:6098, NCIT:C4576] +synonym: "malignant tumor of the thalamus" EXACT [NCIT:C4576] +synonym: "thalamic neoplasm" RELATED [DOID:6098] +synonym: "tumor of thalamus" EXACT [DOID:6098, NCIT:C6221] +xref: DOID:6098 {source="MONDO:equivalentTo"} +xref: NCIT:C4576 {source="MONDO:equivalentTo", source="DOID:6098"} +xref: SCTID:188287005 {source="MONDO:equivalentTo", source="DOID:6098"} +xref: UMLS:C0346902 {source="MONDO:equivalentTo", source="NCIT:C4576", source="DOID:6098"} +is_a: MONDO:0002786 {source="DOID:6098", source="MONDO:Redundant", source="NCIT:C4576"} ! diencephalic cancer +is_a: MONDO:0003081 ! thalamic disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001897 ! dorsal plus ventral thalamus +property_value: exactMatch DOID:6098 +property_value: exactMatch http://identifiers.org/snomedct/188287005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346902 +property_value: exactMatch NCIT:C4576 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003767 +name: mitral valve disorder +def: "A disease involving the mitral valve." [https://orcid.org/0000-0002-6601-2165] +synonym: "chronic rheumatic mitral valve" EXACT [DOID:61] +synonym: "disease of mitral valve" EXACT [DOID:61, ICD9CM:394, MONDO:patterns/location_top] +synonym: "disease or disorder of mitral valve" EXACT [] +synonym: "disorder of mitral valve" EXACT [MONDO:patterns/location_top] +synonym: "mitral RH valve dis." EXACT [DOID:61] +synonym: "mitral valve disease" EXACT [MONDO:patterns/location] +synonym: "mitral valve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "mitral valve disorder" EXACT [NCIT:C78446] +synonym: "rheumatic disease of mitral valve" NARROW [DOID:61] +synonym: "rheumatic mitral insufficiency" NARROW [DOID:61, ICD9CM:394.1] +synonym: "rheumatic mitral valve changes" NARROW [DOID:61] +synonym: "rheumatic mitral valve incompetence" NARROW [DOID:61] +synonym: "rheumatic mitral valve regurgitation" NARROW [DOID:61] +xref: DOID:61 {source="MONDO:equivalentTo"} +xref: ICD9:394 {source="DOID:61"} +xref: ICD9:394.1 {source="DOID:61"} +xref: ICD9:394.9 +xref: ICD9:424.0 {source="DOID:61"} +xref: NCIT:C78446 {source="MONDO:equivalentTo", source="DOID:61"} +xref: SCTID:11851006 {source="MONDO:equivalentTo", source="DOID:61"} +xref: UMLS:C0026265 {source="MONDO:equivalentTo", source="NCIT:C78446", source="DOID:61"} +xref: UMLS:C2939153 {source="MONDO:equivalentTo"} +is_a: MONDO:0002869 {source="DOID:61", source="MONDO:Redundant", source="NCIT:C78446"} ! heart valve disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002135 ! mitral valve +relationship: disease_has_location UBERON:0002135 ! mitral valve +property_value: exactMatch DOID:61 +property_value: exactMatch http://identifiers.org/snomedct/11851006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026265 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2939153 +property_value: exactMatch NCIT:C78446 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003769 +name: herpetic gastritis +def: "Gastritis resulting from herpes virus." [NCIT:P378] +synonym: "Herpesviridae caused viral gastritis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Herpesviridae viral gastritis" EXACT [] +xref: DOID:6102 {source="MONDO:equivalentTo"} +xref: NCIT:C27341 {source="DOID:6102", source="MONDO:equivalentTo"} +xref: UMLS:C1333996 {source="DOID:6102", source="MONDO:equivalentTo"} +is_a: MONDO:0002270 {source="DOID:6102", source="MONDO:Redundant", source="NCIT:C27341"} ! viral gastritis +is_a: MONDO:0005794 ! Herpesviridae infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0000945 ! stomach +intersection_of: MONDO:0100332 NCBITaxon:10292 ! disease has primary infectious agent Herpesviridae +property_value: exactMatch DOID:6102 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333996 +property_value: exactMatch NCIT:C27341 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003771 +name: jugular foramen meningioma +def: "A meningioma that affects the jugular foramen." [NCIT:P378] +synonym: "jugular foramen meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of jugular foramen" EXACT [] +synonym: "meningioma of jugular Foramen" EXACT [NCIT:C5293] +synonym: "meningioma of the jugular Foramen" EXACT [DOID:6110, NCIT:C5293] +xref: DOID:6110 {source="MONDO:equivalentTo"} +xref: NCIT:C5293 {source="MONDO:equivalentTo", source="DOID:6110"} +xref: UMLS:C1334298 {source="MONDO:equivalentTo", source="DOID:6110", source="NCIT:C5293"} +is_a: MONDO:0016642 {source="DOID:6110", source="MONDO:Redundant", source="NCIT:C5293/inferred"} ! meningioma +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0005456 ! jugular foramen +relationship: disease_has_location UBERON:0005456 ! jugular foramen +property_value: exactMatch DOID:6110 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334298 +property_value: exactMatch NCIT:C5293 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003772 +name: cerebral meningioma +def: "A meningioma that affects the cerebral hemispheres." [NCIT:P378] +synonym: "cerebral hemispheric meningioma" EXACT [NCIT:C4807] +synonym: "meningioma (disease) of telencephalon" EXACT [] +synonym: "meningioma of cerebral hemispheres" EXACT [NCIT:C4807] +synonym: "meningioma of cerebrum" EXACT [DOID:6112, NCIT:C4807] +synonym: "meningioma of the cerebral hemispheres" EXACT [NCIT:C4807] +synonym: "meningioma of the cerebrum" EXACT [NCIT:C4807] +synonym: "telencephalon meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:6112 {source="MONDO:equivalentTo"} +xref: NCIT:C4807 {source="MONDO:equivalentTo", source="DOID:6112"} +xref: SCTID:189164002 {source="MONDO:equivalentTo", source="DOID:6112"} +xref: UMLS:C0542564 {source="NCIT:C4807", source="MONDO:equivalentTo", source="DOID:6112"} +is_a: MONDO:0000642 {source="DOID:6112", source="MONDO:Entailed", source="MONDO:Redundant"} ! brain meningioma +is_a: MONDO:0002731 {source="DOID:6112", source="MONDO:Entailed"} ! cerebral hemisphere cancer +is_a: MONDO:0021322 ! malignant tumor of meninges +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0001893 ! telencephalon +property_value: exactMatch DOID:6112 +property_value: exactMatch http://identifiers.org/snomedct/189164002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0542564 +property_value: exactMatch NCIT:C4807 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003775 +name: lateral ventricle meningioma +def: "A meningioma that affects the lateral ventricle of the brain." [NCIT:P378] +synonym: "meningioma (disease) of telencephalic ventricle" EXACT [] +synonym: "meningioma of lateral ventricle" EXACT [NCIT:C5302] +synonym: "meningioma of the lateral ventricle" EXACT [DOID:6115, NCIT:C5302] +synonym: "telencephalic ventricle meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:6115 {source="MONDO:equivalentTo"} +xref: NCIT:C5302 {source="DOID:6115", source="MONDO:equivalentTo"} +xref: UMLS:C1334380 {source="DOID:6115", source="MONDO:equivalentTo", source="NCIT:C5302"} +is_a: MONDO:0002772 {source="DOID:6115", source="MONDO:Redundant", source="NCIT:C5302"} ! intraventricular meningioma +is_a: MONDO:0003772 ! cerebral meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0002285 ! telencephalic ventricle +relationship: disease_has_location UBERON:0002285 ! telencephalic ventricle +property_value: exactMatch DOID:6115 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334380 +property_value: exactMatch NCIT:C5302 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003778 +name: inborn errors of immunity +def: "A disorder in which the immune system is unable to mount an adequate immune response." [NCIT:P378] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:101997"} +synonym: "antibody deficiency syndrome" RELATED [MESH:D007153] +synonym: "antibody deficiency syndromes" RELATED [MESH:D007153] +synonym: "deficiency syndrome, antibody" RELATED [MESH:D007153] +synonym: "deficiency syndrome, immunologic" RELATED [MESH:D007153] +synonym: "deficiency syndrome, immunological" RELATED [MESH:D007153] +synonym: "deficiency syndromes, antibody" RELATED [MESH:D007153] +synonym: "deficiency syndromes, immunologic" RELATED [MESH:D007153] +synonym: "deficiency syndromes, immunological" RELATED [MESH:D007153] +synonym: "hypoimmunity" EXACT [DOID:612] +synonym: "IEI" EXACT ABBREVIATION [https://github.com/monarch-initiative/mondo/issues/4115] +synonym: "immune deficiency disorder" EXACT [DOID:612] +synonym: "immunodeficiency syndrome" EXACT [DOID:612, NCIT:C3131] +synonym: "immunologic deficiency syndrome" RELATED [MESH:D007153] +synonym: "immunological deficiency syndrome" RELATED [MESH:D007153] +synonym: "immunological deficiency syndromes" RELATED [MESH:D007153] +synonym: "primary immunodeficiency" RELATED [Orphanet:101997] +synonym: "primary immunodeficiency disease" EXACT [https://github.com/monarch-initiative/mondo/issues/4115] +synonym: "syndrome, antibody deficiency" RELATED [MESH:D007153] +synonym: "syndrome, immunologic deficiency" RELATED [MESH:D007153] +synonym: "syndrome, immunological deficiency" RELATED [MESH:D007153] +synonym: "syndromes, antibody deficiency" RELATED [MESH:D007153] +synonym: "syndromes, immunologic deficiency" RELATED [MESH:D007153] +synonym: "syndromes, immunological deficiency" RELATED [MESH:D007153] +xref: DOID:612 {source="MONDO:equivalentTo"} +xref: ICD9:279.3 {source="DOID:612", source="MONDO:directSiblingOf"} +xref: KEGG:05340 {source="DOID:612", source="MONDO:relatedTo"} +xref: MESH:D007153 {source="DOID:612", source="MONDO:equivalentTo"} +xref: NCIT:C3131 {source="DOID:612", source="MONDO:directSiblingOf"} +xref: NCIT:C39725 {source="DOID:612", source="MONDO:finding", source="MONDO:otherHierarchy"} +xref: Orphanet:101997 {source="MONDO:EquivalentTo"} +xref: SCTID:234532001 {source="DOID:612", source="MONDO:directSiblingOf"} +xref: SCTID:58606001 {source="MONDO:EquivalentTo"} +xref: UMLS:C0021051 {source="DOID:612", source="MONDO:equivalentTo"} +xref: UMLS:C0398686 {source="MONDO:EquivalentTo", source="Orphanet:101997", source="MONDO:notFoundInDiseaseSubset"} +is_a: MONDO:0009453 {source="https://github.com/monarch-initiative/mondo/issues/1143"} ! immune deficiency disease +property_value: exactMatch DOID:612 +property_value: exactMatch http://identifiers.org/mesh/D007153 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0021051 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0005046 {source="DOID:612", source="MESH:D007153"} +property_value: relatedMatch NCIT:C39725 + +[Term] +id: MONDO:0003781 +name: bronchitis +def: "An acute or chronic inflammatory process affecting the bronchi." [NCIT:C2911] +synonym: "acute bronchitis" NARROW [DOID:6132, NCIT:C26932] +synonym: "acute bronchitis and bronchiolitis" RELATED [DOID:6132] +synonym: "bronchial infection" EXACT [NCIT:C2911] +synonym: "bronchus inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "chest cold" RELATED [DOID:6132] +synonym: "chest infection" RELATED [DOID:6132] +synonym: "chronic bronchitis" NARROW [DOID:6132] +synonym: "CI - chest infection" EXACT [DOID:6132] +synonym: "inflammation of bronchus" EXACT [] +synonym: "recurrent wheezy bronchitis" RELATED [DOID:6132] +xref: CSP:2596-1500 {source="DOID:6132"} +xref: DOID:6132 {source="MONDO:equivalentTo"} +xref: EFO:0009661 {source="MONDO:equivalentTo"} +xref: ICD9:466.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:6132"} +xref: ICD9:490 {source="DOID:6132"} +xref: ICD9:491 {source="DOID:6132"} +xref: ICD9:491.9 {source="DOID:6132"} +xref: MESH:D001991 {source="MONDO:equivalentTo", source="DOID:6132"} +xref: NCIT:C2911 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:6132"} +xref: SCTID:32398004 {source="MONDO:equivalentTo", source="DOID:6132"} +xref: UMLS:C0006277 {source="MONDO:equivalentTo", source="DOID:6132", source="NCIT:C2911"} +is_a: MONDO:0001358 {source="DOID:6132", source="MESH:D001991", source="MONDO:Redundant"} ! bronchial disorder +is_a: MONDO:0021925 ! tracheobronchitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002185 ! bronchus +relationship: disease_has_inflammation_site UBERON:0002185 ! bronchus +property_value: exactMatch DOID:6132 +property_value: exactMatch http://identifiers.org/mesh/D001991 +property_value: exactMatch http://identifiers.org/snomedct/32398004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006277 +property_value: exactMatch NCIT:C2911 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003790 +name: prostatic urethra urothelial carcinoma +def: "An urothelial carcinoma that arises from the urothelial lining of the prostatic urethra." [NCIT:C39900] +synonym: "prostatic urethra urothelial carcinoma" EXACT [NCIT:C39900] +xref: DOID:6166 {source="MONDO:equivalentTo"} +xref: NCIT:C39900 {source="MONDO:equivalentTo", source="DOID:6166"} +xref: UMLS:C1514522 {source="MONDO:equivalentTo", source="NCIT:C39900", source="DOID:6166"} +is_a: MONDO:0002834 {source="NCIT:C39900"} ! primary prostate urothelial carcinoma +is_a: MONDO:0002836 {source="MONDO:Redundant", source="NCIT:C39900"} ! urethra transitional cell carcinoma +is_a: MONDO:0003791 {source="DOID:6166", source="NCIT:C39900"} ! prostatic urethral cancer +intersection_of: MONDO:0002836 ! urethra transitional cell carcinoma +intersection_of: disease_arises_from_structure UBERON:0001335 ! prostatic urethra +relationship: disease_arises_from_structure UBERON:0001335 ! prostatic urethra +relationship: disease_arises_from_structure UBERON:0015777 ! transitional epithelium of prostatic urethra +property_value: exactMatch DOID:6166 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514522 +property_value: exactMatch NCIT:C39900 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003791 +name: prostatic urethral cancer +def: "A male urethral cancer that involves the prostatic urethra." [MONDO:patterns/location] +synonym: "male urethral cancer of prostatic urethra" EXACT [MONDO:design_pattern] +synonym: "prostatic urethra male urethral cancer" EXACT [MONDO:patterns/location] +synonym: "prostatic urethral malignant neoplasm" EXACT [NCIT:C39870] +xref: DOID:6167 {source="MONDO:equivalentTo"} +xref: NCIT:C39870 {source="MONDO:equivalentTo", source="DOID:6167"} +xref: UMLS:C1514523 {source="NCIT:C39870", source="MONDO:equivalentTo", source="DOID:6167"} +is_a: MONDO:0004197 {source="DOID:6167", source="MONDO:Redundant", source="NCIT:C39870"} ! male urethral cancer +intersection_of: MONDO:0004197 ! male urethral cancer +intersection_of: disease_has_location UBERON:0001335 ! prostatic urethra +relationship: disease_has_location UBERON:0001335 ! prostatic urethra +property_value: exactMatch DOID:6167 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1514523 +property_value: exactMatch NCIT:C39870 + +[Term] +id: MONDO:0003799 +name: conjunctivitis +def: "Inflammation of the conjunctiva of the eye." [NCIT:P378] +synonym: "conjunctiva inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "conjunctivitis" EXACT [MONDO:ambiguous] +synonym: "conjunctivitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "inflammation of conjunctiva" EXACT [] +synonym: "Madras eye" RELATED [DOID:6195] +synonym: "pink eye" EXACT [NCIT:C34504] +xref: DOID:6195 {source="MONDO:equivalentTo"} +xref: HP:0000509 {source="MONDO:otherHierarchy"} +xref: ICD9:372.30 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:6195"} +xref: ICD9:372.39 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003231 {source="MONDO:equivalentTo", source="DOID:6195"} +xref: NCIT:C34504 {source="MONDO:equivalentTo", source="DOID:6195"} +xref: SCTID:9826008 {source="MONDO:equivalentTo", source="DOID:6195"} +xref: UMLS:C0009763 {source="MONDO:equivalentTo", source="DOID:6195", source="NCIT:C34504"} +is_a: MONDO:0006170 {source="DOID:6195", source="MESH:D003231", source="MONDO:Redundant"} ! conjunctival disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +relationship: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:6195 +property_value: exactMatch http://identifiers.org/mesh/D003231 +property_value: exactMatch http://identifiers.org/snomedct/9826008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009763 +property_value: exactMatch NCIT:C34504 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "conjunctivitis (disease)" xsd:string + +[Term] +id: MONDO:0003802 +name: cornea cancer +def: "A malignant neoplasm involving the cornea." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of cornea" EXACT [MONDO:patterns/cancer] +synonym: "cornea cancer" EXACT [MONDO:patterns/location] +synonym: "corneal tumor" BROAD [DOID:6199, NCIT:C4361] +synonym: "malignant cornea neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3565] +synonym: "malignant cornea tumor" EXACT [NCIT:C3565] +synonym: "malignant corneal neoplasm" EXACT [NCIT:C3565] +synonym: "malignant corneal tumor" EXACT [DOID:6199, NCIT:C3565] +synonym: "malignant neoplasm of cornea" EXACT [DOID:6199, MONDO:patterns/cancer, NCIT:C3565] +synonym: "malignant neoplasm of cornea (primary)" EXACT [DOID:6199] +synonym: "malignant neoplasm of the cornea" EXACT [NCIT:C3565] +synonym: "malignant tumor of cornea" EXACT [NCIT:C3565] +synonym: "malignant tumor of the cornea" EXACT [NCIT:C3565] +xref: DOID:6199 {source="MONDO:equivalentTo"} +xref: ICD9:190.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:6199"} +xref: NCIT:C3565 {source="MONDO:equivalentTo", source="DOID:6199"} +xref: SCTID:363464006 {source="MONDO:equivalentTo", source="DOID:6199"} +xref: UMLS:C0153629 {source="MONDO:equivalentTo", source="NCIT:C3565", source="DOID:6199"} +is_a: MONDO:0000653 ! integumentary system cancer +is_a: MONDO:0002236 {source="DOID:6199", source="MONDO:Redundant", source="NCIT:C3565"} ! ocular cancer +is_a: MONDO:0021238 {source="MONDO:Redundant", source="NCIT:C3565"} ! cornea neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch DOID:6199 +property_value: exactMatch http://identifiers.org/snomedct/363464006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153629 +property_value: exactMatch NCIT:C3565 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0003803 +name: aortic valve disorder +def: "A disease involving the aortic valve." [https://orcid.org/0000-0002-6601-2165] +synonym: "aortic valve disease" EXACT [MONDO:patterns/location] +synonym: "aortic valve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "aortic valve disorder" EXACT [NCIT:C78650] +synonym: "disease of aortic valve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of aortic valve" EXACT [] +synonym: "disorder of aortic valve" EXACT [MONDO:patterns/location_top] +xref: DOID:62 {source="MONDO:equivalentTo"} +xref: ICD9:395 {source="DOID:62"} +xref: ICD9:424.1 {source="DOID:62"} +xref: NCIT:C78650 {source="MONDO:equivalentTo", source="DOID:62"} +xref: UMLS:C1260873 {source="MONDO:equivalentTo", source="NCIT:C78650", source="DOID:62"} +is_a: MONDO:0002869 {source="DOID:62", source="MONDO:Redundant", source="NCIT:C78650"} ! heart valve disorder +is_a: MONDO:0005561 {source="MONDO:cjm"} ! aortic disorder +is_a: MONDO:0045001 ! cardiac ventricle disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002137 ! aortic valve +relationship: disease_has_location UBERON:0002137 ! aortic valve +property_value: exactMatch DOID:62 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1260873 +property_value: exactMatch NCIT:C78650 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003812 +name: ovarian endometrial cancer +def: "A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells." [NCIT:P378] +synonym: "endometrioid neoplasm of ovary" EXACT [DOID:6212, NCIT:C6257] +synonym: "endometrioid tumor of ovary" EXACT [MONDO:design_pattern] +synonym: "malignant ovarian endometrioid tumor" EXACT [DOID:6212, NCIT:C40051] +synonym: "ovarian endometrioid neoplasm" EXACT [DOID:6212] +synonym: "ovary endometrioid tumor" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "ovary female reproductive endometrioid cancer" EXACT [MONDO:patterns/location] +xref: DOID:6212 {source="MONDO:equivalentTo"} +xref: NCIT:C40051 {source="DOID:6212", source="MONDO:equivalentTo"} +xref: UMLS:C1518231 {source="DOID:6212", source="MONDO:equivalentTo", source="NCIT:C40051"} +is_a: MONDO:0002480 {source="DOID:6212", source="MONDO:Redundant", source="NCIT:C40051/inferred"} ! endometrioid tumor +is_a: MONDO:0018364 {source="MONDO:Redundant", source="NCIT:C40051"} ! malignant epithelial tumor of ovary +intersection_of: MONDO:0002480 ! endometrioid tumor +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:6212 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518231 +property_value: exactMatch NCIT:C40051 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0003816 +name: articular cartilage disorder +def: "A disease involving the articular cartilage of joint." [https://orcid.org/0000-0002-6601-2165] +synonym: "articular cartilage disorder" EXACT [] +synonym: "articular cartilage disorder involving ankle and foot" NARROW [DOID:6227, ICD9CM:718.07] +synonym: "articular cartilage disorder involving forearm" NARROW [DOID:6227, ICD9CM:718.03] +synonym: "articular cartilage disorder involving hand" NARROW [DOID:6227, ICD9CM:718.04] +synonym: "articular cartilage disorder involving multiple sites" NARROW [DOID:6227, ICD9CM:718.09] +synonym: "articular cartilage disorder involving pelvic region and thigh" NARROW [DOID:6227, ICD9CM:718.05] +synonym: "articular cartilage disorder involving shoulder region" NARROW [DOID:6227, ICD9CM:718.01] +synonym: "articular cartilage disorder involving upper arm" NARROW [DOID:6227, ICD9CM:718.02] +synonym: "articular cartilage disorder of ankle and/or foot" NARROW [DOID:6227] +synonym: "articular cartilage disorder of forearm" NARROW [DOID:6227] +synonym: "articular cartilage disorder of hand" NARROW [DOID:6227] +synonym: "articular cartilage disorder of multiple sites" NARROW [DOID:6227] +synonym: "articular cartilage disorder of shoulder region" NARROW [DOID:6227] +synonym: "articular cartilage disorder of the pelvic region and thigh" NARROW [DOID:6227] +synonym: "articular cartilage disorder of upper arm" NARROW [DOID:6227] +synonym: "articular cartilage of joint disease" EXACT [MONDO:patterns/location] +synonym: "articular cartilage of joint disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of articular cartilage of joint" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of articular cartilage of joint" EXACT [] +synonym: "disorder of articular cartilage" RELATED [] +synonym: "disorder of articular cartilage of joint" EXACT [MONDO:patterns/location_top] +xref: DOID:6227 {source="MONDO:equivalentTo"} +xref: ICD9:718.0 {source="DOID:6227"} +xref: ICD9:718.00 {source="DOID:6227"} +xref: ICD9:718.02 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:53417006 {source="DOID:6227", source="MONDO:equivalentTo"} +xref: UMLS:C0158073 {source="DOID:6227", source="MONDO:equivalentTo"} +is_a: MONDO:0006816 {source="DOID:6227", source="MONDO:Redundant"} ! arthropathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0010996 ! articular cartilage of joint +relationship: disease_has_location UBERON:0010996 ! articular cartilage of joint +property_value: exactMatch DOID:6227 +property_value: exactMatch http://identifiers.org/snomedct/53417006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0158073 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003828 +name: growth hormone-producing pituitary gland carcinoma +def: "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces growth hormone. It may be associated with acromegaly." [NCIT:C5963] +synonym: "Growth hormone producing pituitary gland carcinoma" EXACT [NCIT:C5963] +synonym: "Growth hormone-producing pituitary gland carcinoma" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing neoplasm of pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing neoplasm of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing neoplasm of the pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing neoplasm of the pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing pituitary gland neoplasm" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing pituitary gland tumor" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing pituitary neoplasm" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing pituitary tumor" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing tumor" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing tumor of pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing tumor of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing tumor of the pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone producing tumor of the pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting neoplasm of pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting neoplasm of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting neoplasm of the pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting neoplasm of the pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting pituitary gland neoplasm" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting pituitary gland tumor" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting pituitary neoplasm" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting pituitary tumor" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting tumor of pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting tumor of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting tumor of the pituitary" EXACT [NCIT:C5963] +synonym: "malignant Growth hormone secreting tumor of the pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant pituitary gland Somatotrophinoma" EXACT [NCIT:C5963] +synonym: "malignant pituitary gland somatotropinoma" EXACT [NCIT:C5963] +synonym: "malignant pituitary Somatotrophinoma" EXACT [NCIT:C5963] +synonym: "malignant pituitary somatotropinoma" EXACT [NCIT:C5963] +synonym: "malignant Somatotrophinoma of pituitary" EXACT [NCIT:C5963] +synonym: "malignant Somatotrophinoma of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant Somatotrophinoma of the pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant somatotropinoma" EXACT [DOID:6256, NCIT:C5963] +synonym: "malignant somatotropinoma of pituitary" EXACT [NCIT:C5963] +synonym: "malignant somatotropinoma of pituitary gland" EXACT [NCIT:C5963] +synonym: "malignant somatotropinoma of the pituitary" EXACT [NCIT:C5963] +synonym: "malignant somatotropinoma of the pituitary gland" EXACT [NCIT:C5963] +xref: DOID:6256 {source="MONDO:equivalentTo"} +xref: NCIT:C5963 {source="DOID:6256", source="MONDO:equivalentTo"} +xref: UMLS:C1334587 {source="DOID:6256", source="MONDO:equivalentTo", source="NCIT:C5963"} +is_a: MONDO:0002038 ! head and neck carcinoma +is_a: MONDO:0002109 ! pituitary cancer +is_a: MONDO:0002415 ! bone carcinoma +is_a: MONDO:0019927 {source="MONDO:Redundant", source="NCIT:C5963"} ! growth hormone-producing pituitary gland neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +intersection_of: realized_in GO:0030252 ! growth hormone secretion +property_value: exactMatch DOID:6256 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334587 +property_value: exactMatch NCIT:C5963 +property_value: excluded_subClassOf MONDO:0003604 {source="DOID:6256"} + +[Term] +id: MONDO:0003834 +name: gastric cardia carcinoma +def: "A carcinoma that arises from epithelial cells of the cardia of stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of gastric cardia" EXACT [NCIT:C6794] +synonym: "cancer of the gastric cardia" EXACT [NCIT:C6794] +synonym: "carcinoma of cardia of stomach" EXACT [DOID:6270, MONDO:patterns/carcinoma, NCIT:C6794] +synonym: "carcinoma of gastric cardia" EXACT [NCIT:C6794] +synonym: "carcinoma of the cardia of the stomach" EXACT [NCIT:C6794] +synonym: "carcinoma of the gastric cardia" EXACT [NCIT:C6794] +synonym: "cardia of stomach carcinoma" EXACT [MONDO:patterns/location] +synonym: "gastric cardia (stomach) cancer" EXACT [NCIT:C6794] +synonym: "gastric cardia cancer" EXACT [NCIT:C6794] +xref: DOID:6270 {source="MONDO:equivalentTo"} +xref: EFO:1001252 {source="MONDO:equivalentTo"} +xref: NCIT:C6794 {source="MONDO:equivalentTo", source="DOID:6270"} +xref: UMLS:C1333763 {source="MONDO:equivalentTo", source="DOID:6270"} +is_a: MONDO:0001063 {source="DOID:6270", source="MONDO:Redundant"} ! cardia cancer +is_a: MONDO:0004950 {source="DOID:6270", source="EFO:1001252", source="MONDO:Redundant", source="NCIT:C6794"} ! gastric carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001162 ! cardia of stomach +property_value: exactMatch DOID:6270 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333763 +property_value: exactMatch NCIT:C6794 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003835 +name: gastric cardia adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the cardia of stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of cardia of stomach" EXACT [DOID:6271, NCIT:C5247] +synonym: "adenocarcinoma of gastric cardia" RELATED [DOID:6271] +synonym: "adenocarcinoma of the cardia of the stomach" EXACT [NCIT:C5247] +synonym: "adenocarcinoma of the gastric cardia" EXACT [NCIT:C5247] +synonym: "cardia of stomach adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:6271 {source="MONDO:equivalentTo"} +xref: NCIT:C5247 {source="MONDO:equivalentTo", source="DOID:6271"} +xref: UMLS:C1333762 {source="MONDO:equivalentTo", source="DOID:6271", source="NCIT:C5247"} +is_a: MONDO:0003834 {source="DOID:6271", source="MONDO:Redundant", source="NCIT:C5247"} ! gastric cardia carcinoma +is_a: MONDO:0005036 {source="DOID:6271", source="MONDO:Redundant", source="NCIT:C5247/inferred"} ! gastric adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001162 ! cardia of stomach +property_value: exactMatch DOID:6271 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333762 +property_value: exactMatch NCIT:C5247 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003842 +name: childhood cerebellar astrocytic neoplasm +def: "Benign and malignant astrocytomas that arise from astrocytes in the cerebellum. More than 80% of childhood cerebellar astrocytomas are pilocytic astrocytomas which have a favorable prognosis. The remainder are composed of diffuse or fibrillary subtypes with malignant astrocytomas occurring only rarely in the cerebellum during childhood." [NCIT:P378] +synonym: "cerebellar astrocytoma" BROAD [NCIT:C6286] +synonym: "cerebellar astrocytoma, childhood" RELATED [GARD:0009301] +synonym: "cerebellum childhood astrocytic tumor" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "cerebellum juvenile astrocytoma" EXACT [MONDO:patterns/location] +synonym: "childhood astrocytic tumor of cerebellum" EXACT [MONDO:design_pattern] +synonym: "childhood astrocytoma of cerebellum" EXACT [NCIT:C6286] +synonym: "childhood astrocytoma of the cerebellum" EXACT [NCIT:C6286] +synonym: "childhood cerebellar astrocytoma" EXACT [NCIT:C6286] +synonym: "pediatric astrocytoma of cerebellum" EXACT [DOID:6286, NCIT:C6286] +synonym: "pediatric astrocytoma of the cerebellum" EXACT [NCIT:C6286] +synonym: "pediatric cerebellar astrocytoma" EXACT [NCIT:C6286] +xref: DOID:6286 {source="MONDO:equivalentTo"} +xref: GARD:0009301 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: NCIT:C6286 {source="MONDO:equivalentTo", source="DOID:6286"} +xref: UMLS:C0278594 {source="NCIT:C6286", source="MONDO:equivalentTo", source="DOID:6286"} +is_a: MONDO:0002505 {source="DOID:6286", source="MONDO:Redundant", source="NCIT:C6286/inferred"} ! childhood astrocytic tumor +is_a: MONDO:0003165 {source="DOID:6286", source="MONDO:Entailed", source="NCIT:C6286"} ! cerebellar astrocytoma +is_a: MONDO:0003263 {source="NCIT:C6286"} ! childhood cerebellar neoplasm +intersection_of: MONDO:0002505 ! childhood astrocytic tumor +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch DOID:6286 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278594 +property_value: exactMatch NCIT:C6286 + +[Term] +id: MONDO:0003846 +name: viral esophagitis +def: "Viral infection of the esophagus. It often occurs in immunocompromised patients and it is caused by cytomegalovirus or herpes simplex virus. Symptoms include pain on swallowing, fever, and retrosternal burning." [NCIT:C27108] +synonym: "viral esophagitis" EXACT [NCIT:C27108] +synonym: "Viruses caused esophagitis (disease)" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses esophagitis (disease)" EXACT [] +xref: DOID:6297 {source="MONDO:equivalentTo"} +xref: NCIT:C27108 {source="MONDO:equivalentTo", source="NCIT:C27108", source="DOID:6297"} +xref: SCTID:235603003 {source="MONDO:equivalentTo", source="DOID:6297"} +xref: UMLS:C0341110 {source="MONDO:equivalentTo", source="NCIT:C27108", source="DOID:6297"} +is_a: MONDO:0001409 {source="DOID:6297", source="MONDO:Redundant", source="NCIT:C27108"} ! esophagitis +is_a: MONDO:0043424 ! digestive system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0001043 ! esophagus +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch DOID:6297 +property_value: exactMatch http://identifiers.org/snomedct/235603003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341110 +property_value: exactMatch NCIT:C27108 + +[Term] +id: MONDO:0003847 +name: Mendelian disease +def: "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome." [MONDO:cjm] +comment: Usage note: this is intended only for diseases with an inherited genetic etiology. Somatic genetic mutations are excluded. Some ontologies use the term 'genetic disease' in the sense of inherited disorders only, we are here careful to distinguish. +subset: harrisons_view +synonym: "familial disorder" RELATED [] +synonym: "genetic condition" BROAD [NCIT:C3101] +synonym: "genetic disease" BROAD [] +synonym: "genetic disorder" BROAD [NCIT:C3101] +synonym: "hereditary disease" EXACT [MONDO:patterns/hereditary, NCIT:C3101] +synonym: "hereditary disease or disorder" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary diseases" EXACT [NCIT:C3101] +synonym: "inborn disorder" RELATED [] +synonym: "inherited disease" EXACT [NCIT:C3101] +synonym: "inherited genetic disease" EXACT [https://github.com/monarch-initiative/mondo/issues/1758] +synonym: "molecular disease" EXACT [NCIT:C3101] +xref: DOID:630 {source="MONDO:equivalentTo"} +xref: EFO:0000508 {source="MONDO:equivalentTo"} +xref: ICD9:799.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D030342 {source="EFO:0000508", source="MONDO:equivalentTo", source="DOID:630"} +xref: NCIT:C3101 {source="EFO:0000508", source="MONDO:equivalentTo", source="DOID:630"} +xref: SCTID:32895009 {source="MONDO:equivalentTo", source="DOID:630"} +xref: UMLS:C0019247 {source="EFO:0000508", source="MONDO:equivalentTo", source="NCIT:C3101", source="DOID:630"} +is_a: MONDO:0000001 {source="DOID:630", source="EFO:0000508", source="MONDO:Redundant", source="NCIT:C3101"} ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:630 +property_value: exactMatch http://identifiers.org/mesh/D030342 +property_value: exactMatch http://identifiers.org/snomedct/32895009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019247 +property_value: exactMatch NCIT:C3101 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml + +[Term] +id: MONDO:0003853 +name: Bartholin gland adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the major vestibular gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of Bartholin's gland" RELATED [DOID:6316] +synonym: "adenocarcinoma of the Bartholin's gland" EXACT [DOID:6316, NCIT:C7719] +synonym: "Bartholin gland adenocarcinoma" EXACT [DOID:6316] +synonym: "major vestibular gland adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:6316 {source="MONDO:equivalentTo"} +xref: NCIT:C7719 {source="DOID:6316", source="MONDO:equivalentTo"} +xref: UMLS:C0238016 {source="NCIT:C7719", source="DOID:6316", source="MONDO:equivalentTo"} +is_a: MONDO:0002829 {source="DOID:6316", source="MONDO:Redundant", source="NCIT:C7719"} ! bartholin gland carcinoma +is_a: MONDO:0024336 {source="DOID:6316", source="MONDO:Redundant", source="NCIT:C7719"} ! vulvar adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch DOID:6316 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238016 +property_value: exactMatch NCIT:C7719 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0003861 +name: vulvar eccrine adenocarcinoma +def: "An eccrine adenocarcinoma that arises from the sweat glands in the vulva." [NCIT:C40305] +synonym: "eccrine carcinoma of mammalian vulva" EXACT [MONDO:design_pattern] +synonym: "mammalian vulva eccrine carcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vulvar eccrine adenocarcinoma" EXACT [NCIT:C40305] +xref: DOID:6339 {source="MONDO:equivalentTo"} +xref: NCIT:C40305 {source="MONDO:equivalentTo", source="DOID:6339", source="MONDO:exact-label-match"} +xref: UMLS:C2202743 {source="NCIT:C40305", source="MONDO:equivalentTo"} +is_a: MONDO:0024240 {source="MONDO:Redundant", source="NCIT:C40305"} ! eccrine carcinoma +is_a: MONDO:0024336 {source="DOID:6339", source="MONDO:Redundant", source="NCIT:C40305/inferred"} ! vulvar adenocarcinoma +intersection_of: MONDO:0024240 ! eccrine carcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:6339 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2202743 +property_value: exactMatch NCIT:C40305 + +[Term] +id: MONDO:0003869 +name: childhood brain stem glioma +def: "An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location. It presents most commonly in the first two decades of life." [NCIT:C9042] +subset: gard_rare {source="GARD:0009306"} +synonym: "brain stem glioma" BROAD [NCIT:C9042] +synonym: "brain stem glioma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "childhood brain stem glioma" EXACT [NCIT:C9042] +synonym: "childhood brainstem glioma" EXACT [NCIT:C9042] +synonym: "childhood glioma of brain stem" EXACT [NCIT:C9042] +synonym: "childhood glioma of brainstem" EXACT [NCIT:C9042] +synonym: "childhood glioma of the brain stem" EXACT [NCIT:C9042] +synonym: "childhood glioma of the brainstem" EXACT [NCIT:C9042] +synonym: "pediatric brain stem glioma" EXACT [MONDO:patterns/childhood, NCIT:C9042] +synonym: "pediatric brainstem glioma" EXACT [NCIT:C9042] +synonym: "pediatric glioma of brain stem" EXACT [NCIT:C9042] +synonym: "pediatric glioma of brainstem" EXACT [NCIT:C9042] +synonym: "pediatric glioma of the brain stem" EXACT [NCIT:C9042] +synonym: "pediatric glioma of the brainstem" EXACT [DOID:6383, NCIT:C9042] +xref: DOID:6383 {source="MONDO:equivalentTo"} +xref: GARD:0009306 {source="MONDO:equivalentTo"} +xref: NCIT:C9042 {source="MONDO:equivalentTo", source="DOID:6383"} +xref: UMLS:C0278600 {source="MONDO:equivalentTo", source="DOID:6383", source="NCIT:C9042"} +is_a: MONDO:0002911 {source="MONDO:Redundant", source="NCIT:C9042"} ! brain stem glioma +is_a: MONDO:0002914 {source="DOID:6383", source="MONDO:Redundant", source="NCIT:C9042"} ! childhood brain stem neoplasm +intersection_of: MONDO:0002911 ! brain stem glioma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6383 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278600 +property_value: exactMatch NCIT:C9042 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9306/childhood-brain-stem-glioma xsd:anyURI {source="GARD:0009306"} + +[Term] +id: MONDO:0003870 +name: childhood brainstem astrocytoma +def: "An astrocytoma that arises from the brain stem and occurs during childhood." [NCIT:P378] +synonym: "brain stem astrocytic neoplasm of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "childhood brain stem astrocytic neoplasm" EXACT [MONDO:design_pattern] +synonym: "childhood brain stem astrocytoma" EXACT [NCIT:C6216] +synonym: "childhood brainstem astrocytoma" EXACT [NCIT:C6216] +synonym: "pediatric brain stem astrocytic neoplasm" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: DOID:6386 {source="MONDO:equivalentTo"} +xref: NCIT:C6216 {source="MONDO:equivalentTo", source="DOID:6386"} +xref: UMLS:C1332950 {source="MONDO:equivalentTo", source="NCIT:C6216", source="DOID:6386"} +is_a: MONDO:0002505 ! childhood astrocytic tumor +is_a: MONDO:0003173 {source="MONDO:Redundant", source="NCIT:C6216"} ! brain stem astrocytic neoplasm +is_a: MONDO:0003869 {source="DOID:6386", source="MONDO:Redundant", source="NCIT:C6216"} ! childhood brain stem glioma +intersection_of: MONDO:0003173 ! brain stem astrocytic neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6386 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332950 +property_value: exactMatch NCIT:C6216 + +[Term] +id: MONDO:0003876 +name: eyelid carcinoma +def: "A carcinoma that arises from epithelial cells of the eyelid." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of eyelid" EXACT [MONDO:patterns/carcinoma, NCIT:C6078] +synonym: "carcinoma of the eyelid" EXACT [DOID:6425, NCIT:C6078] +synonym: "eyelid carcinoma" EXACT [MONDO:patterns/location, NCIT:C6078] +xref: DOID:6425 {source="MONDO:equivalentTo"} +xref: NCIT:C6078 {source="DOID:6425", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0920196 {source="DOID:6425", source="MONDO:equivalentTo"} +is_a: MONDO:0002466 {source="MONDO:Redundant", source="NCIT:C6078"} ! eye carcinoma +is_a: MONDO:0002656 {source="DOID:6425", source="MONDO:Entailed", source="MONDO:Redundant"} ! skin carcinoma +is_a: MONDO:0021313 {source="MONDO:Redundant", source="NCIT:C6078"} ! eyelid cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch DOID:6425 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0920196 +property_value: exactMatch NCIT:C6078 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003881 +name: vulvar apocrine adenocarcinoma +def: "An apocrine adenocarcinoma that arises from the sweat glands in the vulva." [NCIT:C40308] +synonym: "apocrine adenocarcinoma of mammalian vulva" EXACT [MONDO:design_pattern] +synonym: "mammalian vulva apocrine adenocarcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vulvar apocrine adenocarcinoma" EXACT [NCIT:C40308] +xref: DOID:6448 {source="MONDO:equivalentTo"} +xref: NCIT:C40308 {source="DOID:6448", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C2202741 {source="NCIT:C40308", source="MONDO:equivalentTo"} +is_a: MONDO:0003214 {source="MONDO:Redundant", source="NCIT:C40308"} ! apocrine adenocarcinoma +is_a: MONDO:0024336 {source="DOID:6448", source="MONDO:Redundant", source="NCIT:C40308/inferred"} ! vulvar adenocarcinoma +intersection_of: MONDO:0003214 ! apocrine adenocarcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:6448 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2202741 +property_value: exactMatch NCIT:C40308 + +[Term] +id: MONDO:0003890 +name: infiltrating bladder urothelial carcinoma +def: "An invasive transitional cell carcinoma that arises from the urinary bladder urothelium." [NCIT:C27885] +synonym: "infiltrating bladder urothelial carcinoma" EXACT [NCIT:C27885] +synonym: "infiltrating transitional cell carcinoma of the urinary bladder" EXACT [NCIT:C27885] +synonym: "invasive bladder transitional cell carcinoma" EXACT [NCIT:C27885] +synonym: "invasive bladder urothelial carcinoma" EXACT [DOID:6477, NCIT:C27885] +synonym: "invasive transitional cell carcinoma of the urinary bladder" EXACT [NCIT:C27885] +xref: DOID:6477 {source="MONDO:equivalentTo"} +xref: NCIT:C27885 {source="DOID:6477", source="MONDO:equivalentTo", source="NCIT:C27885"} +xref: UMLS:C1334281 {source="DOID:6477", source="MONDO:equivalentTo", source="NCIT:C27885"} +is_a: MONDO:0005611 {source="DOID:6477", source="NCIT:C27885"} ! bladder transitional cell carcinoma +is_a: MONDO:0040678 ! infiltrating urothelial carcinoma +intersection_of: MONDO:0005611 ! bladder transitional cell carcinoma +intersection_of: has_modifier PATO:0002129 ! neoplastic, invasive +property_value: exactMatch DOID:6477 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334281 +property_value: exactMatch NCIT:C27885 + +[Term] +id: MONDO:0003900 +name: connective tissue disorder +def: "A disease involving the connective tissue." [https://orcid.org/0000-0002-6601-2165] +comment: Following clinical usage of the term 'connective tissue disorder' this grouping excludes some diseases affecting tissues classically considered to be connective tissue, such as bone. +synonym: "connective tissue disease" EXACT [MONDO:patterns/location] +synonym: "connective tissue disease or disorder" EXACT [MONDO:patterns/location] +synonym: "connective tissue diseases" EXACT [NCIT:C26729] +synonym: "connective tissue disorder" EXACT [DOID:65] +synonym: "connective tissue disorders" EXACT [NCIT:C26729] +synonym: "disease of connective tissue" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of connective tissue" EXACT [] +synonym: "disease, connective tissue" EXACT [NCIT:C26729] +synonym: "disorder of connective tissue" EXACT [DOID:65, MONDO:patterns/location_top] +synonym: "primary disorder of connective tissue" EXACT [NCIT:C26729] +synonym: "tissue disease, connective" EXACT [NCIT:C26729] +xref: DOID:65 {source="MONDO:equivalentTo"} +xref: MESH:D003240 {source="DOID:65", source="MONDO:equivalentTo"} +xref: NCIT:C26729 {source="DOID:65", source="MONDO:equivalentTo"} +xref: SCTID:105969002 {source="DOID:65", source="MONDO:equivalentTo"} +xref: UMLS:C0009782 {source="NCIT:C26729", source="DOID:65", source="MONDO:equivalentTo"} +is_a: MONDO:0000001 {source="https://orcid.org/0000-0001-5208-3432"} ! disease or disorder +property_value: exactMatch DOID:65 +property_value: exactMatch http://identifiers.org/mesh/D003240 +property_value: exactMatch http://identifiers.org/snomedct/105969002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009782 +property_value: exactMatch NCIT:C26729 +property_value: excluded_subClassOf MONDO:0002081 {source="DOID:65"} +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3570 xsd:string + +[Term] +id: MONDO:0003908 +name: clivus meningioma +def: "A meningioma that affects the clivus." [NCIT:P378] +synonym: "clivus of occipital bone meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of clivus of occipital bone" EXACT [] +synonym: "meningioma of clivus" EXACT [NCIT:C5289] +synonym: "meningioma of the clivus" EXACT [DOID:6517, NCIT:C5289] +xref: DOID:6517 {source="MONDO:equivalentTo"} +xref: NCIT:C5289 {source="MONDO:equivalentTo", source="DOID:6517"} +xref: UMLS:C1333073 {source="MONDO:equivalentTo", source="NCIT:C5289", source="DOID:6517"} +is_a: MONDO:0002919 {source="DOID:6517", source="NCIT:C5289"} ! posterior cranial fossa meningioma +is_a: MONDO:0002998 {source="DOID:6517", source="NCIT:C5289"} ! skull base meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0004108 ! clivus of occipital bone +relationship: disease_has_location UBERON:0004108 ! clivus of occipital bone +property_value: exactMatch DOID:6517 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333073 +property_value: exactMatch NCIT:C5289 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0003917 +name: heart lymphoma +def: "An extranodal lymphoma that arises from the heart and/or the pericardium. The majority of the cases are diffuse large B-cell lymphomas. Patients may present with chest pain, heart failure, pericardial effusion, arrhythmia, or syncope." [NCIT:P378] +synonym: "Cardiac lymphoma" EXACT [NCIT:C5368] +synonym: "heart lymphoma" EXACT [MONDO:patterns/location, NCIT:C5368] +synonym: "lymphoma of heart" EXACT [DOID:6547, NCIT:C5368] +synonym: "lymphoma of the heart" EXACT [NCIT:C5368] +synonym: "PCL" EXACT ABBREVIATION [NCIT:C5368] +synonym: "primary Cardiac lymphoma" EXACT [NCIT:C5368] +synonym: "Primary heart lymphoma" EXACT [NCIT:C5368] +xref: DOID:6547 {source="MONDO:equivalentTo"} +xref: NCIT:C5368 {source="DOID:6547", source="MONDO:equivalentTo"} +xref: UMLS:C1332850 {source="DOID:6547", source="MONDO:equivalentTo", source="NCIT:C5368"} +is_a: MONDO:0001340 {source="DOID:6547", source="NCIT:C5368"} ! heart cancer +is_a: MONDO:0005062 {source="DOID:6547", source="MONDO:Redundant", source="NCIT:C5368/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch DOID:6547 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332850 +property_value: exactMatch NCIT:C5368 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0003926 +name: neurilemmoma of the pleura +def: "A schwannoma that involves the pleura." [MONDO:patterns/location] +synonym: "neurilemmoma of pleura" EXACT [NCIT:C5418] +synonym: "pleura schwannoma" EXACT [MONDO:patterns/location] +synonym: "pleural neurilemmoma" EXACT [NCIT:C5418] +synonym: "pleural schwannoma" EXACT [NCIT:C5418] +synonym: "schwannoma of pleura" EXACT [DOID:6564, NCIT:C5418] +synonym: "schwannoma of the pleura" EXACT [NCIT:C5418] +xref: DOID:6564 {source="MONDO:equivalentTo"} +xref: NCIT:C5418 {source="DOID:6564", source="MONDO:equivalentTo"} +xref: UMLS:C1335435 {source="DOID:6564", source="MONDO:equivalentTo", source="NCIT:C5418"} +is_a: MONDO:0004820 {source="DOID:6564", source="NCIT:C5418"} ! peripheral nerve schwannoma +is_a: MONDO:0021065 ! pleural neoplasm +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0000977 ! pleura +property_value: exactMatch DOID:6564 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335435 +property_value: exactMatch NCIT:C5418 + +[Term] +id: MONDO:0003931 +name: childhood optic tract astrocytoma +def: "An astrocytoma that arises from the visual pathway and occurs during childhood." [NCIT:P378] +synonym: "childhood optic tract astrocytoma" EXACT [NCIT:C7534] +synonym: "childhood visual pathway astrocytoma" EXACT [NCIT:C7534] +synonym: "optic tract astrocytoma of childhood" EXACT [MONDO:patterns/childhood] +synonym: "pediatric optic tract astrocytoma" EXACT [MONDO:patterns/childhood, NCIT:C7534] +synonym: "pediatric visual pathway astrocytoma" EXACT [DOID:6575, NCIT:C7534] +xref: DOID:6575 {source="MONDO:equivalentTo"} +xref: NCIT:C7534 {source="DOID:6575", source="MONDO:equivalentTo"} +xref: UMLS:C1333014 {source="DOID:6575", source="MONDO:equivalentTo", source="NCIT:C7534"} +is_a: MONDO:0004071 ! childhood cerebral astrocytoma +is_a: MONDO:0024649 ! optic tract astrocytoma +intersection_of: MONDO:0024649 ! optic tract astrocytoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6575 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333014 +property_value: exactMatch NCIT:C7534 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0003234 {source="DOID:6575"} +property_value: excluded_subClassOf MONDO:0003932 {source="NCIT:C7534"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml + +[Term] +id: MONDO:0003932 +name: childhood optic nerve glioma +def: "A glioma affecting the optic tract and occurring in childhood." [NCIT:C7535] +synonym: "childhood optic tract glioma" EXACT [NCIT:C7535] +synonym: "childhood visual pathway glioma" EXACT [NCIT:C7535] +synonym: "glioma of childhood visual pathway" EXACT [NCIT:C7535] +synonym: "glioma of pediatric visual pathway" EXACT [NCIT:C7535] +synonym: "glioma of the childhood visual pathway" EXACT [NCIT:C7535] +synonym: "glioma of the pediatric visual pathway" EXACT [DOID:6576, NCIT:C7535] +synonym: "optic nerve glioma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric optic nerve glioma" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric optic tract glioma" EXACT [NCIT:C7535] +synonym: "pediatric visual pathway glioma" EXACT [NCIT:C7535] +synonym: "visual pathway and hypothalamic glioma, childhood" RELATED [GARD:0009309] +synonym: "visual pathway glioma" BROAD [NCIT:C7535] +xref: DOID:6576 {source="MONDO:equivalentTo"} +xref: GARD:0009309 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: NCIT:C7535 {source="DOID:6576", source="MONDO:equivalentTo"} +is_a: MONDO:0003235 {source="DOID:6576", source="MONDO:Redundant"} ! optic nerve glioma +is_a: MONDO:0021079 ! childhood neoplasm +intersection_of: MONDO:0003235 ! optic nerve glioma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:6576 +property_value: exactMatch NCIT:C7535 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml + +[Term] +id: MONDO:0003933 +name: chest wall bone cancer +def: "An uncommon malignant neoplasm that arises from the chest wall bones. Representative examples include chondrosarcoma, osteosarcoma, and Ewing sarcoma/peripheral primitive neuroectodermal tumor." [NCIT:P378] +synonym: "bone cancer of chest wall" EXACT [MONDO:design_pattern] +synonym: "chest wall bone cancer" EXACT [MONDO:patterns/location] +synonym: "malignant bone neoplasm of chest wall" RELATED [DOID:6579] +synonym: "malignant bone neoplasm of the chest wall" EXACT [NCIT:C6724] +synonym: "malignant bone tumor of chest wall" EXACT [NCIT:C6724] +synonym: "malignant bone tumor of the chest wall" EXACT [DOID:6579, NCIT:C6724] +synonym: "malignant chest wall bone neoplasm" EXACT [NCIT:C6724] +synonym: "malignant chest wall bone tumor" EXACT [NCIT:C6724] +xref: DOID:6579 {source="MONDO:equivalentTo"} +xref: NCIT:C6724 {source="DOID:6579", source="MONDO:equivalentTo"} +xref: UMLS:C1334572 {source="DOID:6579", source="MONDO:equivalentTo", source="NCIT:C6724"} +is_a: MONDO:0002129 {source="DOID:6579", source="MONDO:Redundant", source="NCIT:C6724"} ! bone cancer +is_a: MONDO:0021323 {source="MONDO:Redundant", source="NCIT:C6724"} ! malignant neoplasm of chest wall +intersection_of: MONDO:0002129 ! bone cancer +intersection_of: disease_has_location UBERON:0016435 ! chest wall +property_value: exactMatch DOID:6579 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334572 +property_value: exactMatch NCIT:C6724 +property_value: excluded_subClassOf MONDO:0003985 {source="DOID:6579"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0003934 +name: breast apocrine carcinoma +def: "An adenocarcinoma of the breast characterized by the presence of two intermingled cellular components: cells with abundant granular, eosinophilic cytoplasm, and cells with abundant cytoplasm containing fine empty vacuoles." [NCIT:C5141] +synonym: "apocrine adenocarcinoma of breast" EXACT [MONDO:design_pattern] +synonym: "apocrine breast carcinoma" EXACT [NCIT:C5141] +synonym: "apocrine carcinoma of breast" EXACT [DOID:6581, NCIT:C5141] +synonym: "apocrine carcinoma of the breast" EXACT [NCIT:C5141] +synonym: "breast apocrine adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "breast apocrine carcinoma" EXACT [DOID:6581, NCIT:C5141] +xref: DOID:6581 {source="MONDO:equivalentTo"} +xref: NCIT:C5141 {source="MONDO:equivalentTo", source="DOID:6581"} +xref: UMLS:C1332316 {source="NCIT:C5141", source="MONDO:equivalentTo", source="DOID:6581"} +is_a: MONDO:0003214 {source="DOID:6581", source="MONDO:Redundant", source="NCIT:C5141"} ! apocrine adenocarcinoma +is_a: MONDO:0005590 {source="NCIT:C5141"} ! breast ductal adenocarcinoma +intersection_of: MONDO:0003214 ! apocrine adenocarcinoma +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:6581 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332316 +property_value: exactMatch NCIT:C5141 + +[Term] +id: MONDO:0003937 +name: spondylitis +def: "The inflammation of a vertebra." [NCIT:C116779] +synonym: "inflammation of vertebra" EXACT [] +synonym: "vertebra inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:6590 {source="MONDO:equivalentTo"} +xref: ICD9:720.8 {source="DOID:6590"} +xref: ICD9:720.89 {source="DOID:6590"} +xref: MESH:D013166 {source="MONDO:equivalentTo"} +xref: NCIT:C116779 {source="MONDO:equivalentTo"} +xref: SCTID:84172003 {source="MONDO:equivalentTo"} +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C116779"} ! inflammatory disease +is_a: MONDO:0045002 ! vertebral disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002412 ! vertebra +relationship: disease_has_inflammation_site UBERON:0002412 ! vertebra +property_value: exactMatch DOID:6590 +property_value: exactMatch http://identifiers.org/mesh/D013166 +property_value: exactMatch http://identifiers.org/snomedct/84172003 +property_value: exactMatch NCIT:C116779 +property_value: excluded_subClassOf MONDO:0005095 {source="DOID:6590"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0003939 +name: muscle tissue disorder +def: "A disease involving the muscle tissue." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of muscle tissue" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of muscle tissue" EXACT [] +synonym: "disorder of muscle tissue" EXACT [MONDO:patterns/location_top] +synonym: "muscle tissue disease" EXACT [MONDO:patterns/location] +synonym: "muscle tissue disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:66 {source="MONDO:equivalentTo"} +xref: ICD10CM:M60-M63 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +is_a: MONDO:0005218 {source="DOID:66"} ! muscular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002385 ! muscle tissue +relationship: disease_has_location UBERON:0002385 ! muscle tissue +property_value: exactMatch DOID:66 +property_value: exactMatch https://icd.codes/icd10cm/M60-M63 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0003950 +name: nipple carcinoma +def: "A carcinoma that arises from epithelial cells of the nipple" [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of nipple" EXACT [MONDO:patterns/carcinoma] +synonym: "nipple cancer" EXACT [NCIT:C28432] +synonym: "nipple carcinoma" EXACT [MONDO:patterns/location, NCIT:C28432] +xref: DOID:6629 {source="MONDO:equivalentTo"} +xref: NCIT:C28432 {source="MONDO:equivalentTo", source="DOID:6629", source="MONDO:exact-label-match"} +xref: UMLS:C1334966 {source="NCIT:C28432", source="MONDO:equivalentTo", source="DOID:6629"} +is_a: MONDO:0002482 {source="MONDO:Redundant", source="NCIT:C28432/inferred"} ! nipple neoplasm +is_a: MONDO:0004989 {source="DOID:6629", source="MONDO:Redundant", source="NCIT:C28432"} ! breast carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002030 ! nipple +property_value: exactMatch DOID:6629 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334966 +property_value: exactMatch NCIT:C28432 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003970 +name: gastric fundus carcinoma +def: "A carcinoma that arises from epithelial cells of the fundus of stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of fundus of stomach" BROAD [DOID:6700, NCIT:C8398] +synonym: "cancer of gastric fundus" BROAD [NCIT:C8398] +synonym: "cancer of the fundus of the stomach" BROAD [NCIT:C8398] +synonym: "cancer of the gastric fundus" BROAD [NCIT:C8398] +synonym: "carcinoma of fundus of stomach" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of gastric fundus" EXACT [NCIT:C8398] +synonym: "carcinoma of the fundus of the stomach" EXACT [NCIT:C8398] +synonym: "carcinoma of the gastric fundus" EXACT [NCIT:C8398] +synonym: "fundus of stomach carcinoma" EXACT [MONDO:patterns/location] +synonym: "gastric fundus (stomach) cancer" BROAD [NCIT:C8398] +synonym: "gastric fundus cancer" EXACT [NCIT:C8398] +xref: DOID:6700 {source="MONDO:equivalentTo"} +xref: NCIT:C8398 {source="DOID:6700", source="MONDO:equivalentTo"} +xref: SCTID:254555008 {source="DOID:6700", source="MONDO:equivalentTo"} +xref: UMLS:C0345799 {source="NCIT:C8398", source="DOID:6700", source="MONDO:equivalentTo"} +is_a: MONDO:0004950 {source="DOID:6700", source="MONDO:Redundant", source="NCIT:C8398"} ! gastric carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001160 ! fundus of stomach +relationship: disease_has_location UBERON:0001160 ! fundus of stomach +property_value: exactMatch DOID:6700 +property_value: exactMatch http://identifiers.org/snomedct/254555008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345799 +property_value: exactMatch NCIT:C8398 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003972 +name: gastric body carcinoma +def: "A carcinoma that arises from epithelial cells of the body of stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "body of stomach carcinoma" EXACT [MONDO:patterns/location] +synonym: "cancer of body of stomach" EXACT [DOID:6705, NCIT:C8399] +synonym: "cancer of gastric body" EXACT [NCIT:C8399] +synonym: "cancer of the body of the stomach" EXACT [NCIT:C8399] +synonym: "cancer of the gastric body" EXACT [NCIT:C8399] +synonym: "carcinoma of body of stomach" EXACT [MONDO:patterns/carcinoma, NCIT:C8399] +synonym: "carcinoma of gastric body" EXACT [NCIT:C8399] +synonym: "carcinoma of the body of the stomach" EXACT [NCIT:C8399] +synonym: "carcinoma of the gastric body" EXACT [NCIT:C8399] +synonym: "gastric body (stomach) cancer" EXACT [NCIT:C8399] +synonym: "gastric body cancer" EXACT [NCIT:C8399] +synonym: "gastric body carcinoma" EXACT [NCIT:C8399] +xref: DOID:6705 {source="MONDO:equivalentTo"} +xref: NCIT:C8399 {source="MONDO:equivalentTo", source="DOID:6705", source="MONDO:exact-label-match"} +xref: SCTID:254557000 {source="MONDO:equivalentTo", source="DOID:6705"} +xref: UMLS:C0345804 {source="NCIT:C8399", source="MONDO:equivalentTo", source="DOID:6705"} +is_a: MONDO:0004950 {source="DOID:6705", source="MONDO:Redundant", source="NCIT:C8399"} ! gastric carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001161 ! body of stomach +relationship: disease_has_location UBERON:0001161 ! body of stomach +property_value: exactMatch DOID:6705 +property_value: exactMatch http://identifiers.org/snomedct/254557000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345804 +property_value: exactMatch NCIT:C8399 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003975 +name: Littre gland carcinoma +def: "A carcinoma involving a male urethral gland." [MONDO:patterns/carcinoma] +synonym: "carcinoma of LittrC) glands" EXACT [NCIT:C39865] +synonym: "carcinoma of Littre glands" EXACT [NCIT:C39865] +synonym: "carcinoma of Littré glands" EXACT [NCIT:C39865] +synonym: "carcinoma of male urethral gland" EXACT [MONDO:patterns/carcinoma] +synonym: "male urethral gland carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:6721 {source="MONDO:equivalentTo"} +xref: NCIT:C39865 {source="DOID:6721", source="MONDO:equivalentTo"} +xref: UMLS:C1516285 {source="DOID:6721", source="MONDO:equivalentTo", source="NCIT:C39865"} +is_a: MONDO:0004197 {source="MONDO:Redundant", source="NCIT:C39865"} ! male urethral cancer +is_a: MONDO:0021327 {source="MONDO:Redundant", source="NCIT:C39865/inferred"} ! carcinoma of urethra +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0010186 ! male urethral gland +relationship: disease_has_location UBERON:0010186 ! male urethral gland +property_value: exactMatch DOID:6721 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1516285 +property_value: exactMatch NCIT:C39865 +property_value: excluded_subClassOf MONDO:0005836 {source="DOID:6721"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0003980 +name: schwannoma of jugular foramen +def: "A rare intracranial schwannoma that affects the jugular foramen." [NCIT:P378] +synonym: "jugular Foramen neurilemmoma" EXACT [NCIT:C5323] +synonym: "jugular foramen schwannoma" EXACT [MONDO:patterns/location] +synonym: "neurilemmoma of jugular Foramen" EXACT [DOID:6735, NCIT:C5323] +synonym: "neurilemmoma of the jugular Foramen" EXACT [NCIT:C5323] +synonym: "schwannoma of the jugular Foramen" EXACT [NCIT:C5323] +xref: DOID:6735 {source="MONDO:equivalentTo"} +xref: NCIT:C5323 {source="MONDO:equivalentTo", source="DOID:6735"} +xref: UMLS:C1334300 {source="MONDO:equivalentTo", source="NCIT:C5323", source="DOID:6735"} +is_a: MONDO:0004820 {source="DOID:6735", source="NCIT:C5323"} ! peripheral nerve schwannoma +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0005456 ! jugular foramen +relationship: disease_has_location UBERON:0005456 ! jugular foramen +property_value: exactMatch DOID:6735 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334300 +property_value: exactMatch NCIT:C5323 + +[Term] +id: MONDO:0003985 +name: chest wall lymphoma +def: "A lymphoma that affects the structures of the chest wall. The majority of cases are diffuse large B-cell lymphomas." [NCIT:C6712] +synonym: "chest wall cancer" BROAD [DOID:6758] +synonym: "chest wall lymphoma" EXACT [MONDO:patterns/location] +synonym: "lymphoma of chest wall" EXACT [DOID:6758] +synonym: "lymphoma of the chest wall" EXACT [DOID:6758, NCIT:C6712] +synonym: "primary chest wall lymphoma" EXACT [NCIT:C6712] +xref: DOID:6758 {source="MONDO:equivalentTo"} +xref: NCIT:C6712 {source="DOID:6758", source="MONDO:equivalentTo"} +xref: UMLS:C1332933 {source="DOID:6758", source="MONDO:equivalentTo", source="NCIT:C6712"} +is_a: MONDO:0005062 {source="MONDO:Redundant", source="NCIT:C6712/inferred"} ! lymphoma +is_a: MONDO:0021323 {source="MONDO:Redundant", source="NCIT:C6712"} ! malignant neoplasm of chest wall +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0016435 ! chest wall +property_value: exactMatch DOID:6758 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332933 +property_value: exactMatch NCIT:C6712 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0003987 +name: lung lymphoma +def: "A rare non-Hodgkin or Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis." [NCIT:P378] +synonym: "lung lymphoma" EXACT [MONDO:patterns/location] +synonym: "lymphoma of lung" EXACT [DOID:6760] +synonym: "lymphoma of the lung" EXACT [NCIT:C4794] +synonym: "primary lung lymphoma" EXACT [NCIT:C4794] +synonym: "pulmonary lymphoma" EXACT [DOID:6760, NCIT:C4794] +xref: DOID:6760 {source="MONDO:equivalentTo"} +xref: NCIT:C4794 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1704383 {source="MONDO:equivalentTo"} +is_a: MONDO:0005062 {source="DOID:6760", source="MONDO:Redundant", source="NCIT:C4794/inferred"} ! lymphoma +is_a: MONDO:0008903 {source="DOID:6760", source="NCIT:C4794"} ! lung cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:6760 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1704383 +property_value: exactMatch NCIT:C4794 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0003988 +name: sternum lymphoma +def: "A rare lymphoma that arises from the bone or soft tissue of the sternum." [NCIT:P378] +synonym: "lymphoma of sternum" EXACT [DOID:6762, NCIT:C6716] +synonym: "lymphoma of the sternum" EXACT [DOID:6762] +synonym: "primary sternal lymphoma" EXACT [NCIT:C6716] +synonym: "sternal lymphoma" EXACT [NCIT:C6716] +synonym: "sternum lymphoma" EXACT [MONDO:patterns/location] +xref: DOID:6762 {source="MONDO:equivalentTo"} +xref: NCIT:C6716 {source="DOID:6762", source="MONDO:equivalentTo"} +xref: UMLS:C1336504 {source="DOID:6762", source="MONDO:equivalentTo", source="NCIT:C6716"} +is_a: MONDO:0003273 {source="DOID:6762", source="NCIT:C6716"} ! sternum cancer +is_a: MONDO:0017814 ! primary bone lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000975 ! sternum +property_value: exactMatch DOID:6762 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336504 +property_value: exactMatch NCIT:C6716 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0003996 +name: basal ganglia disorder +def: "A disease involving the basal ganglia." [https://orcid.org/0000-0002-6601-2165] +synonym: "basal ganglia disease" EXACT [MONDO:patterns/location] +synonym: "collection of basal ganglia disease" EXACT [MONDO:patterns/location] +synonym: "collection of basal ganglia disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of basal ganglia" EXACT [MONDO:patterns/location_top] +synonym: "disease of collection of basal ganglia" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of collection of basal ganglia" EXACT [] +synonym: "disorder of basal ganglia" RELATED [MONDO:patterns/location_top] +synonym: "disorder of collection of basal ganglia" EXACT [MONDO:patterns/location_top] +xref: CSP:2057-3403 {source="DOID:679"} +xref: DOID:679 {source="MONDO:equivalentTo"} +xref: ICD9:333.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001480 {source="DOID:679", source="MONDO:equivalentTo"} +xref: SCTID:70835005 {source="DOID:679", source="MONDO:equivalentTo"} +xref: UMLS:C0004782 {source="DOID:679", source="MONDO:equivalentTo"} +is_a: MONDO:0005560 {source="DOID:679", source="MESH:D001480", source="MONDO:Redundant"} ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0010011 ! collection of basal ganglia +relationship: disease_has_location UBERON:0010011 ! collection of basal ganglia +property_value: exactMatch DOID:679 +property_value: exactMatch http://identifiers.org/mesh/D001480 +property_value: exactMatch http://identifiers.org/snomedct/70835005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004782 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004010 +name: infiltrating renal pelvis/ureter urothelial carcinoma +synonym: "infiltrating renal pelvis and ureter transitional cell carcinoma" EXACT [NCIT:C39879] +synonym: "infiltrating renal pelvis and ureter urothelial carcinoma" EXACT [NCIT:C39879] +synonym: "infiltrating ureter transitional cell carcinoma" NARROW [DOID:6845] +xref: NCIT:C39879 {source="MONDO:equivalentTo", source="DOID:6845"} +xref: UMLS:C1512750 {source="MONDO:equivalentTo", source="DOID:6845", source="NCIT:C39879"} +is_a: MONDO:0040678 {source="NCIT:C39879"} ! infiltrating urothelial carcinoma +intersection_of: MONDO:0040678 ! infiltrating urothelial carcinoma +intersection_of: disease_has_location UBERON:0036295 ! renal pelvis/ureter +relationship: disease_has_location UBERON:0036295 ! renal pelvis/ureter +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512750 +property_value: exactMatch NCIT:C39879 + +[Term] +id: MONDO:0004021 +name: mediastinal malignant lymphoma +def: "A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma." [NCIT:P378] +synonym: "lymphoma of mediastinum" EXACT [DOID:6868, NCIT:C6633] +synonym: "lymphoma of the mediastinum" EXACT [NCIT:C6633] +synonym: "mediastinal lymphoma" EXACT [NCIT:C6633] +synonym: "mediastinal malignant lymphoma" EXACT [NCIT:C6633] +synonym: "mediastinum lymphoma" EXACT [MONDO:patterns/location] +synonym: "primary mediastinal lymphoma" EXACT [NCIT:C6633] +xref: DOID:6868 {source="MONDO:equivalentTo"} +xref: NCIT:C6633 {source="DOID:6868", source="MONDO:equivalentTo"} +xref: UMLS:C1334665 {source="DOID:6868", source="MONDO:equivalentTo", source="NCIT:C6633"} +is_a: MONDO:0005062 {source="DOID:6868", source="MONDO:Redundant", source="NCIT:C6633/inferred"} ! lymphoma +is_a: MONDO:0005843 {source="DOID:6868", source="NCIT:C6633"} ! mediastinal cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch DOID:6868 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334665 +property_value: exactMatch NCIT:C6633 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004030 +name: ureter transitional cell carcinoma +def: "A carcinoma that arises from the transitional epithelium of the ureter. It is associated with tobacco use and usually presents with gross or microscopic hematuria." [NCIT:P378] +synonym: "transitional cell carcinoma of the ureter" EXACT [NCIT:C4830] +synonym: "transitional cell carcinoma of ureter" EXACT [NCIT:C4830] +synonym: "ureter transitional cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4830] +synonym: "ureter urothelial cancer" EXACT [NCIT:C4830] +synonym: "ureter urothelial carcinoma" EXACT [NCIT:C4830] +synonym: "ureteral transitional cell carcinoma" EXACT [NCIT:C4830] +synonym: "ureteral urothelial cell carcinoma" EXACT [DOID:6888, NCIT:C4830] +synonym: "urothelial cell carcinoma of the ureter" EXACT [NCIT:C4830] +synonym: "urothelial cell carcinoma of ureter" EXACT [NCIT:C4830] +xref: DOID:6888 {source="MONDO:equivalentTo"} +xref: EFO:1001973 {source="MONDO:equivalentTo"} +xref: NCIT:C4830 {source="DOID:6888", source="MONDO:equivalentTo"} +xref: SCTID:300988009 {source="DOID:6888", source="MONDO:equivalentTo"} +xref: UMLS:C0577692 {source="DOID:6888", source="MONDO:equivalentTo", source="NCIT:C4830"} +is_a: MONDO:0006481 {source="DOID:6888", source="EFO:1001973", source="MONDO:Redundant", source="NCIT:C4830"} ! ureter carcinoma +is_a: MONDO:0020654 ! renal pelvis/ureter urothelial carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:6888 +property_value: exactMatch http://identifiers.org/snomedct/300988009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0577692 +property_value: exactMatch NCIT:C4830 + +[Term] +id: MONDO:0004034 +name: eye lymphoma +def: "A lymphoma that involves the eye." [MONDO:patterns/location] +synonym: "eye lymphoma" EXACT [MONDO:patterns/location, NCIT:C35690] +synonym: "eyeball of camera-type eye lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lymphoma of eyeball of camera-type eye" EXACT [MONDO:design_pattern] +synonym: "primary eye lymphoma" EXACT [NCIT:C35690] +xref: DOID:6903 {source="MONDO:equivalentTo"} +xref: NCIT:C35690 {source="MONDO:equivalentTo", source="DOID:6903", source="MONDO:exact-label-match"} +xref: UMLS:C1333519 {source="NCIT:C35690", source="MONDO:equivalentTo", source="DOID:6903"} +is_a: MONDO:0002236 {source="DOID:6903", source="NCIT:C35690"} ! ocular cancer +is_a: MONDO:0005062 {source="DOID:6903", source="MONDO:Redundant", source="NCIT:C35690/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch DOID:6903 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333519 +property_value: exactMatch NCIT:C35690 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004046 +name: childhood brain meningioma +def: "A brain meningioma that occurs during childhood." [NCIT:P378] +synonym: "Brain meningioma" EXACT [NCIT:C6253] +synonym: "brain pediatric meningioma" EXACT [MONDO:patterns/location] +synonym: "childhood meningioma of brain" EXACT [NCIT:C6253] +synonym: "childhood meningioma of the brain" EXACT [NCIT:C6253] +synonym: "pediatric brain meningioma" EXACT [NCIT:C6253] +synonym: "pediatric meningioma of brain" EXACT [DOID:6939, NCIT:C6253] +synonym: "pediatric meningioma of the brain" EXACT [NCIT:C6253] +xref: DOID:6939 {source="MONDO:equivalentTo"} +xref: NCIT:C6253 {source="MONDO:equivalentTo", source="DOID:6939"} +xref: UMLS:C1332949 {source="NCIT:C6253", source="MONDO:equivalentTo", source="DOID:6939"} +is_a: MONDO:0000642 {source="DOID:6939", source="MONDO:Redundant"} ! brain meningioma +is_a: MONDO:0003057 {source="DOID:6939", source="MONDO:Redundant", source="NCIT:C6253"} ! pediatric meningioma +intersection_of: MONDO:0003057 ! pediatric meningioma +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:6939 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332949 +property_value: exactMatch NCIT:C6253 + +[Term] +id: MONDO:0004047 +name: sphenoidal sinus neoplasm +alt_id: MONDO:0021216 +def: "A benign or malignant neoplasm that affects the sphenoid sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:P378] +synonym: "neoplasm of sphenoid sinus" EXACT [NCIT:C6792] +synonym: "neoplasm of sphenoidal sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C6792] +synonym: "neoplasm of the sphenoid sinus" EXACT [NCIT:C6792] +synonym: "neoplasm of the sphenoidal sinus" EXACT [NCIT:C6792] +synonym: "sphenoid sinus neoplasm" EXACT [NCIT:C6792] +synonym: "sphenoid sinus tumor" EXACT [NCIT:C6792] +synonym: "sphenoidal sinus neoplasm" EXACT [NCIT:C6792] +synonym: "sphenoidal sinus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sphenoidal sinus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C6792] +synonym: "tumor of sphenoid sinus" EXACT [NCIT:C6792] +synonym: "tumor of sphenoidal sinus" EXACT [DOID:6947, MONDO:patterns/neoplasm, NCIT:C6792] +synonym: "tumor of the sphenoid sinus" EXACT [NCIT:C6792] +synonym: "tumor of the sphenoidal sinus" EXACT [NCIT:C6792] +xref: DOID:6947 {source="MONDO:equivalentTo"} +xref: NCIT:C6792 {source="MONDO:equivalentTo", source="DOID:6947"} +xref: SCTID:126679002 {source="MONDO:equivalentTo", source="DOID:6947"} +xref: UMLS:C0345676 {source="NCIT:C6792", source="MONDO:equivalentTo", source="DOID:6947"} +is_a: MONDO:0002785 ! skull base neoplasm +is_a: MONDO:0005289 {source="DOID:6947", source="MONDO:Redundant", source="NCIT:C6792"} ! paranasal sinus neoplasm +is_a: MONDO:0023369 ! disorder of facial skeleton +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001724 ! sphenoidal sinus +relationship: disease_has_location UBERON:0001724 ! sphenoidal sinus +property_value: exactMatch DOID:6947 +property_value: exactMatch http://identifiers.org/snomedct/126679002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345676 +property_value: exactMatch NCIT:C6792 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004053 +name: bartholin gland squamous cell carcinoma +def: "A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant squamous epithelial cells." [NCIT:C40293] +synonym: "bartholin gland squamous cell carcinoma" EXACT [NCIT:C40293] +synonym: "Bartholin's gland squamous cell carcinoma" EXACT [DOID:6961, MONDO:0006101, NCIT:C40293] +synonym: "major vestibular gland squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:6961 {source="MONDO:equivalentTo"} +xref: EFO:1000104 {source="MONDO:equivalentTo"} +xref: NCIT:C40293 {source="DOID:6961", source="MONDO:equivalentTo", source="EFO:1000104"} +xref: UMLS:C1511052 {source="DOID:6961", source="MONDO:equivalentTo", source="NCIT:C40293"} +is_a: MONDO:0002829 {source="DOID:6961", source="MONDO:Redundant", source="NCIT:C40293"} ! bartholin gland carcinoma +is_a: MONDO:0024609 {source="DOID:6961", source="MONDO:Redundant", source="NCIT:C40293"} ! vulvar squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch DOID:6961 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511052 +property_value: exactMatch NCIT:C40293 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0004069 +name: inborn mitochondrial metabolism disorder +def: "Diseases caused by abnormal function of the mitochondria. They may be caused by mutations, acquired or inherited, in mitochondrial dna or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes." [MESH:D028361] +subset: disease_grouping +subset: gard_rare +subset: ordo_group_of_disorders {source="Orphanet:68380"} +synonym: "mitochondrial disease" BROAD [MONDO:0019055] +synonym: "mitochondrial genetic disorders" RELATED [GARD:0007048] +synonym: "mitochondrial metabolism disease" RELATED [DOID:700] +xref: DOID:700 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: GARD:0007048 {source="MONDO:equivalentTo"} +xref: MESH:D028361 {source="DOID:700", source="Orphanet:68380", source="MONDO:equivalentTo", source="Orphanet:68380/e"} +xref: Orphanet:68380 {source="MONDO:equivalentTo"} +is_a: MONDO:0015327 {source="Orphanet:68380"} ! developmental anomaly of metabolic origin +is_a: MONDO:0019243 {source="Orphanet:68380"} ! inborn disorder of energy metabolism +is_a: MONDO:0044970 ! mitochondrial disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_dysfunction_of GO:0005739 ! mitochondrion +property_value: exactMatch DOID:700 +property_value: exactMatch http://identifiers.org/mesh/D028361 +property_value: exactMatch Orphanet:68380 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7048/mitochondrial-genetic-disorders xsd:anyURI {source="GARD:0007048"} + +[Term] +id: MONDO:0004071 +name: childhood cerebral astrocytoma +def: "An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children." [NCIT:C4347] +subset: gard_rare {source="GARD:0009302"} +synonym: "cerebral astrocytoma" BROAD [NCIT:C4347] +synonym: "cerebral astrocytoma, childhood" RELATED [GARD:0009302] +synonym: "childhood astrocytic tumor of telencephalon" EXACT [MONDO:design_pattern] +synonym: "childhood astrocytoma of cerebrum" EXACT [NCIT:C4347] +synonym: "childhood astrocytoma of the cerebrum" EXACT [NCIT:C4347] +synonym: "pediatric astrocytoma of cerebrum" EXACT [DOID:7007, NCIT:C4347] +synonym: "pediatric astrocytoma of the cerebrum" EXACT [NCIT:C4347] +synonym: "pediatric cerebral astrocytoma" EXACT [NCIT:C4347] +synonym: "telencephalon childhood astrocytic tumor" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "telencephalon juvenile astrocytoma" EXACT [MONDO:patterns/location] +xref: DOID:7007 {source="MONDO:equivalentTo"} +xref: GARD:0009302 {source="MONDO:equivalentTo"} +xref: NCIT:C4347 {source="DOID:7007", source="MONDO:equivalentTo"} +xref: UMLS:C0338070 {source="DOID:7007", source="MONDO:equivalentTo", source="NCIT:C4347"} +is_a: MONDO:0002505 {source="DOID:7007", source="MONDO:Redundant", source="NCIT:C4347/inferred"} ! childhood astrocytic tumor +is_a: MONDO:0002731 {source="DOID:7007", source="MONDO:Entailed"} ! cerebral hemisphere cancer +is_a: MONDO:0005499 {source="DOID:7007", source="MONDO:Entailed", source="MONDO:Redundant"} ! brain glioma +is_a: MONDO:0006517 ! childhood malignant neoplasm +is_a: MONDO:0021633 ! cerebral astrocytoma +intersection_of: MONDO:0002505 ! childhood astrocytic tumor +intersection_of: disease_has_location UBERON:0001893 ! telencephalon +property_value: exactMatch DOID:7007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0338070 +property_value: exactMatch NCIT:C4347 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9302/cerebral-astrocytoma-childhood xsd:anyURI {source="GARD:0009302"} + +[Term] +id: MONDO:0004080 +name: glottis squamous cell carcinoma +def: "A squamous cell carcinoma of the larynx that arises from the glottic area. It may remain localized for a long period then in late disease stage, it may spread to the opposite true vocal cord, supraglottic and subglottic areas, and the soft tissues of the neck. Hoarseness is the presenting symptom." [NCIT:C8186] +synonym: "epidermoid carcinoma of glottis" EXACT [NCIT:C8186] +synonym: "epidermoid carcinoma of the glottis" EXACT [DOID:7031, NCIT:C8186] +synonym: "glottic epidermoid carcinoma" EXACT [NCIT:C8186] +synonym: "glottic squamous cell carcinoma" EXACT [NCIT:C8186] +synonym: "glottis epidermoid carcinoma" EXACT [NCIT:C8186] +synonym: "glottis squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C8186] +synonym: "squamous cell carcinoma of glottis" EXACT [DOID:7031, NCIT:C8186] +synonym: "squamous cell carcinoma of the glottis" EXACT [NCIT:C8186] +xref: DOID:7031 {source="MONDO:equivalentTo"} +xref: NCIT:C8186 {source="MONDO:equivalentTo", source="DOID:7031"} +xref: UMLS:C0280325 {source="MONDO:equivalentTo", source="DOID:7031", source="NCIT:C8186"} +is_a: MONDO:0002355 {source="DOID:7031", source="MONDO:Redundant", source="NCIT:C8186"} ! glottis carcinoma +is_a: MONDO:0005595 {source="MONDO:Redundant", source="NCIT:C8186"} ! laryngeal squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002486 ! glottis +property_value: exactMatch DOID:7031 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280325 +property_value: exactMatch NCIT:C8186 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0004095 +name: B-cell neoplasm +def: "A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes." [MESH:D016393] +subset: gard_rare {source="GARD:0005877"} +synonym: "B-cell lymphocytic neoplasm" EXACT [DOID:707, NCIT:C27907] +synonym: "B-cell lymphoma" RELATED [DOID:707] +synonym: "B-cell neoplasm" EXACT [NCIT:C27907] +synonym: "lymphoma, B-cell" RELATED [GARD:0005877] +xref: DOID:707 {source="MONDO:equivalentTo"} +xref: GARD:0005877 {source="MONDO:equivalentTo"} +xref: MESH:D016393 {source="MONDO:equivalentTo", source="DOID:707"} +xref: NCIT:C27907 {source="MONDO:equivalentTo", source="DOID:707"} +is_a: MONDO:0004805 {source="DOID:707", source="MONDO:Entailed", source="MONDO:Redundant"} ! leukocyte disorder +is_a: MONDO:0005062 {source="DOID:707/inferred", source="MESH:D016393/inferred", source="MONDO:Redundant"} ! lymphoma +intersection_of: MONDO:0005062 {source="NCIT:C27907"} ! lymphoma +intersection_of: MONDO:0005157 {source="NCIT:C27907"} ! lymphoid neoplasm +intersection_of: disease_arises_from_structure CL:0000236 {source="NCIT:C27907"} ! B cell +intersection_of: disease_has_location CL:0000236 {source="NCIT:C27907"} ! B cell +relationship: disease_arises_from_structure CL:0000236 ! B cell +relationship: disease_has_location CL:0000236 ! B cell +property_value: exactMatch DOID:707 +property_value: exactMatch http://identifiers.org/mesh/D016393 +property_value: exactMatch NCIT:C27907 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5877/B-cell-lymphoma xsd:anyURI {source="GARD:0005877"} + +[Term] +id: MONDO:0004109 +name: epiglottis neoplasm +alt_id: MONDO:0021347 +def: "A benign or malignant neoplasm that affects the epiglottis." [NCIT:P378] +synonym: "epiglottic neoplasm" EXACT [NCIT:C4933] +synonym: "epiglottic tumor" EXACT [DOID:7105, NCIT:C4933] +synonym: "epiglottis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "Epiglottis tumor" EXACT [NCIT:C4933] +synonym: "epiglottis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of Epiglottis" EXACT [NCIT:C4933] +synonym: "neoplasm of epiglottis" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the Epiglottis" EXACT [NCIT:C4933] +synonym: "tumor of Epiglottis" EXACT [NCIT:C4933] +synonym: "tumor of epiglottis" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Epiglottis" EXACT [NCIT:C4933] +xref: DOID:7105 {source="MONDO:equivalentTo"} +xref: NCIT:C4933 {source="DOID:7105", source="MONDO:equivalentTo"} +xref: SCTID:126699008 {source="DOID:7105", source="MONDO:equivalentTo"} +xref: UMLS:C1290353 {source="DOID:7105", source="MONDO:equivalentTo", source="NCIT:C4933"} +is_a: MONDO:0004427 {source="DOID:7105", source="NCIT:C4933"} ! supraglottis neoplasm +is_a: MONDO:0021358 ! neoplasm of hypopharynx +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000388 ! epiglottis +relationship: disease_has_location UBERON:0000388 ! epiglottis +property_value: exactMatch DOID:7105 +property_value: exactMatch http://identifiers.org/snomedct/126699008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290353 +property_value: exactMatch NCIT:C4933 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004126 +name: thyroiditis +def: "Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis." [NCIT:P378] +synonym: "inflammation of thyroid gland" EXACT [] +synonym: "thyroid gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "thyroiditis" EXACT [MONDO:ambiguous] +synonym: "thyroiditis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:7166 {source="MONDO:equivalentTo"} +xref: HP:0100646 {source="MONDO:otherHierarchy"} +xref: ICD9:245 {source="DOID:7166"} +xref: ICD9:245.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:7166"} +xref: MESH:D013966 {source="MONDO:equivalentTo", source="DOID:7166"} +xref: NCIT:C26894 {source="MONDO:equivalentTo", source="DOID:7166"} +xref: SCTID:82119001 {source="MONDO:equivalentTo", source="DOID:7166"} +xref: UMLS:C0040147 {source="NCIT:C26894", source="MONDO:equivalentTo", source="DOID:7166"} +is_a: MONDO:0003240 {source="DOID:7166", source="MESH:D013966", source="MONDO:Redundant", source="NCIT:C26894/inferred"} ! thyroid gland disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002046 ! thyroid gland +relationship: disease_has_inflammation_site UBERON:0002046 ! thyroid gland +property_value: exactMatch DOID:7166 +property_value: exactMatch http://identifiers.org/mesh/D013966 +property_value: exactMatch http://identifiers.org/snomedct/82119001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040147 +property_value: exactMatch NCIT:C26894 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "thyroiditis (disease)" xsd:string + +[Term] +id: MONDO:0004132 +name: anal canal squamous cell carcinoma +def: "A squamous cell carcinoma arising from the mucosa of the anal canal." [NCIT:C7469] +subset: ordo_disease {source="Orphanet:424019"} +synonym: "anal canal squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C7469] +synonym: "squamous cell carcinoma of the anal canal" EXACT [MONDO:0018519] +xref: DOID:7177 {source="MONDO:equivalentTo"} +xref: ICD10CM:C21.1 {source="Orphanet:424019/ntbt", source="Orphanet:424019"} +xref: NCIT:C7469 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:7177"} +xref: Orphanet:424019 {source="MONDO:equivalentTo"} +xref: UMLS:C1332262 {source="MONDO:equivalentTo", source="NCIT:C7469", source="DOID:7177"} +is_a: MONDO:0006082 {source="MONDO:Redundant", source="NCIT:C7469"} ! anal squamous cell carcinoma +is_a: MONDO:0007108 {source="DOID:7177", source="MONDO:Redundant", source="NCIT:C7469", source="Orphanet:424019"} ! anal canal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000159 ! anal canal +property_value: exactMatch DOID:7177 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332262 +property_value: exactMatch NCIT:C7469 +property_value: exactMatch Orphanet:424019 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C21.1 + +[Term] +id: MONDO:0004151 +name: spinal meninges cancer +def: "A malignant neoplasm involving the meninx of spinal cord." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of meninx of spinal cord" EXACT [MONDO:patterns/cancer] +synonym: "malignant meninx of spinal cord neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of meninx of spinal cord" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of spinal meninges" EXACT [DOID:7224] +synonym: "meninx of spinal cord cancer" EXACT [MONDO:patterns/location] +xref: DOID:7224 {source="MONDO:equivalentTo"} +xref: ICD9:192.3 {source="DOID:7224", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363476006 {source="DOID:7224", source="MONDO:equivalentTo"} +xref: UMLS:C0153647 {source="DOID:7224", source="MONDO:equivalentTo"} +is_a: MONDO:0003544 {source="DOID:7224", source="MONDO:Redundant"} ! spinal cord cancer +is_a: MONDO:0021322 {source="MONDO:Redundant"} ! malignant tumor of meninges +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003292 ! meninx of spinal cord +relationship: disease_has_location UBERON:0003292 ! meninx of spinal cord +property_value: exactMatch DOID:7224 +property_value: exactMatch http://identifiers.org/snomedct/363476006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153647 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004163 +name: bladder urachal urothelial carcinoma +def: "A transitional cell carcinoma of the urinary bladder that arises from the urachal epithelium." [NCIT:C39844] +synonym: "bladder urachal urothelial carcinoma" EXACT [NCIT:C39844] +xref: DOID:7244 {source="MONDO:equivalentTo"} +xref: NCIT:C39844 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:7244"} +xref: UMLS:C1511207 {source="MONDO:equivalentTo", source="NCIT:C39844", source="DOID:7244"} +is_a: MONDO:0003715 {source="DOID:7244", source="MONDO:Redundant", source="NCIT:C39844"} ! bladder urachal carcinoma +is_a: MONDO:0005611 {source="MONDO:Redundant", source="NCIT:C39844"} ! bladder transitional cell carcinoma +intersection_of: MONDO:0005611 ! bladder transitional cell carcinoma +intersection_of: disease_arises_from_structure UBERON:0011202 ! urachus epithelium +property_value: exactMatch DOID:7244 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511207 +property_value: exactMatch NCIT:C39844 + +[Term] +id: MONDO:0004166 +name: hereditary fallopian tube carcinoma +def: "Fallopian tube carcinoma that has developed in relatives of patients that have a history of fallopian tube carcinoma." [NCIT:C40455] +synonym: "familial fallopian tube carcinoma" EXACT [NCIT:C40455] +synonym: "familiar fallopian tube carcinoma" RELATED [DOID:7266] +synonym: "hereditary fallopian tube cancer" EXACT [NCIT:C40455] +synonym: "hereditary fallopian tube carcinoma" EXACT [MONDO:patterns/hereditary, NCIT:C40455] +xref: DOID:7266 {source="MONDO:equivalentTo"} +xref: NCIT:C40455 {source="MONDO:equivalentTo", source="DOID:7266"} +xref: UMLS:C1512418 {source="MONDO:equivalentTo", source="DOID:7266", source="NCIT:C40455"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0006206 {source="DOID:7266", source="MONDO:Redundant", source="NCIT:C40455"} ! fallopian tube carcinoma +intersection_of: MONDO:0006206 ! fallopian tube carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:7266 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512418 +property_value: exactMatch NCIT:C40455 + +[Term] +id: MONDO:0004173 +name: adenocarcinoma of skene gland origin +def: "A rare adenocarcinoma arising from Skene gland. It presents as a periurethral or anterior vaginal submucosal mass. It is characterized by morphological features similar to prostate adenocarcinoma." [NCIT:C39863] +synonym: "adenocarcinoma of Skene gland" EXACT [NCIT:C39863] +synonym: "adenocarcinoma of Skene gland origin" EXACT [NCIT:C39863] +synonym: "carcinoma of paraurethral gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of Skene gland" EXACT [NCIT:C39863] +synonym: "carcinoma of Skene's gland" EXACT [NCIT:C39863] +synonym: "carcinoma of the paraurethral gland" EXACT [DOID:7284, NCIT:C7371] +synonym: "paraurethral gland adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "paraurethral gland carcinoma" EXACT [DOID:7284, MONDO:patterns/location] +synonym: "Skene gland carcinoma" RELATED [DOID:7284] +xref: DOID:7284 {source="MONDO:equivalentTo"} +xref: NCIT:C39863 {source="MONDO:equivalentTo", source="DOID:7284"} +xref: UMLS:C1527427 {source="NCIT:C39863", source="MONDO:equivalentTo", source="DOID:7284"} +is_a: MONDO:0001869 {source="DOID:7284", source="MONDO:Entailed", source="MONDO:Redundant"} ! paraurethral gland cancer +is_a: MONDO:0024336 ! vulvar adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0010145 ! paraurethral gland +property_value: exactMatch DOID:7284 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1527427 +property_value: exactMatch NCIT:C39863 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0004177 +name: benign urethral neoplasm +def: "Abnormal growth of the cells of the urethra (lower urinary tract) without malignant characteristics." [NCIT:C3619] +synonym: "benign neoplasm of the urethra" EXACT [NCIT:C3619] +synonym: "benign neoplasm of urethra" EXACT [NCIT:C3619] +synonym: "benign tumor of the urethra" EXACT [NCIT:C3619] +synonym: "benign tumor of urethra" EXACT [NCIT:C3619] +synonym: "benign urethra neoplasm" EXACT [NCIT:C3619] +synonym: "benign urethra tumor" EXACT [NCIT:C3619] +synonym: "benign urethral neoplasm" EXACT [NCIT:C3619] +synonym: "benign urethral tumor" EXACT [NCIT:C3619] +synonym: "neoplasm. urethra" EXACT [DOID:730, NCIT:C3428] +synonym: "urethra benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "urethral benign neoplasm" RELATED [DOID:730] +xref: DOID:730 {source="MONDO:equivalentTo"} +xref: ICD9:223.81 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3619 {source="MONDO:equivalentTo"} +xref: SCTID:92466006 {source="MONDO:equivalentTo"} +is_a: MONDO:0004180 {source="DOID:730", source="MONDO:Redundant", source="NCIT:C3619"} ! benign urinary system neoplasm +is_a: MONDO:0021239 {source="MONDO:Redundant", source="NCIT:C3619"} ! urethra neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:730 +property_value: exactMatch http://identifiers.org/snomedct/92466006 +property_value: exactMatch NCIT:C3619 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0004180 +name: benign urinary system neoplasm +def: "A non-metastasizing neoplasm that arises from the organs that comprise the urinary system. Representative examples include renal oncocytoma, bladder inverted papilloma, and urothelial papilloma." [NCIT:C4893] +synonym: "benign neoplasm of the urinary tract" EXACT [NCIT:C4893] +synonym: "benign neoplasm of urinary tract" EXACT [NCIT:C4893] +synonym: "benign tumor of the urinary tract" EXACT [NCIT:C4893] +synonym: "benign tumor of urinary tract" EXACT [NCIT:C4893] +synonym: "benign urinary system neoplasm" EXACT [NCIT:C4893] +synonym: "benign urinary tract neoplasm" EXACT [NCIT:C4893] +synonym: "benign urinary tract tumor" EXACT [NCIT:C4893] +synonym: "neoplasm of urinary system" BROAD [DOID:731] +synonym: "renal system benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "tumor of the urinary system" BROAD [DOID:731, NCIT:C3431] +synonym: "tumor of urinary tract" BROAD [DOID:731] +synonym: "urinary system benign neoplasm" RELATED [DOID:731] +synonym: "urinary tract neoplasm" BROAD [DOID:731] +xref: DOID:731 {source="MONDO:equivalentTo"} +xref: ICD9:223.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:223.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014571 {source="DOID:731", source="MONDO:equivalentTo"} +xref: NCIT:C4893 {source="MONDO:equivalentTo"} +xref: SCTID:92468007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005165 {source="DOID:731", source="DOID:731/inferred", source="MONDO:Redundant"} ! benign neoplasm +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C4893"} ! urinary system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch DOID:731 +property_value: exactMatch http://identifiers.org/mesh/D014571 +property_value: exactMatch http://identifiers.org/snomedct/92468007 +property_value: exactMatch NCIT:C4893 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0004183 +name: axonal neuropathy +def: "Any nerve disorder affecting the axon of a nerve." [NCIT:C27301] +synonym: "axon peripheral neuropathy" EXACT [MONDO:patterns/location] +synonym: "axonal neuropathy" EXACT [NCIT:C27301] +synonym: "peripheral neuropathy of axon" EXACT [MONDO:design_pattern] +xref: DOID:7319 {source="MONDO:equivalentTo"} +xref: NCIT:C27301 {source="DOID:7319", source="MONDO:equivalentTo"} +xref: SCTID:60703000 {source="DOID:7319", source="MONDO:equivalentTo"} +xref: UMLS:C0270921 {source="NCIT:C27301", source="DOID:7319", source="MONDO:equivalentTo"} +is_a: MONDO:0005244 {source="DOID:7319", source="MONDO:Redundant", source="NCIT:C27301"} ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_location GO:0030424 ! axon +relationship: disease_has_location GO:0030424 ! axon +property_value: exactMatch DOID:7319 +property_value: exactMatch http://identifiers.org/snomedct/60703000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0270921 +property_value: exactMatch NCIT:C27301 + +[Term] +id: MONDO:0004184 +name: urethral disorder +def: "A disease involving the urethra." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of urethra" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of urethra" EXACT [] +synonym: "disorder of urethra" EXACT [MONDO:patterns/location_top] +synonym: "urethra disease" EXACT [DOID:732, MONDO:patterns/location, NCIT:C26903] +synonym: "urethra disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "urethra disorder" EXACT [NCIT:C26903] +xref: DOID:732 {source="MONDO:equivalentTo"} +xref: MESH:D014522 {source="DOID:732", source="MONDO:equivalentTo"} +xref: NCIT:C26903 {source="DOID:732", source="MONDO:equivalentTo"} +xref: SCTID:4985009 {source="DOID:732", source="MONDO:equivalentTo"} +xref: UMLS:C0041969 {source="DOID:732", source="MONDO:equivalentTo", source="NCIT:C26903"} +is_a: MONDO:0002118 {source="DOID:732", source="MESH:D014522", source="MONDO:Redundant", source="NCIT:C26903"} ! urinary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000057 ! urethra +relationship: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:732 +property_value: exactMatch http://identifiers.org/mesh/D014522 +property_value: exactMatch http://identifiers.org/snomedct/4985009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0041969 +property_value: exactMatch NCIT:C26903 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004192 +name: urethra cancer +def: "A malignant neoplasm involving the urethra" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of urethra" EXACT [DOID:734, MONDO:patterns/cancer] +synonym: "malignant neoplasm of the urethra" EXACT [NCIT:C7507] +synonym: "malignant neoplasm of urethra" EXACT [MONDO:patterns/cancer, NCIT:C7507] +synonym: "malignant tumor of the urethra" EXACT [NCIT:C7507] +synonym: "malignant tumor of urethra" EXACT [NCIT:C7507] +synonym: "malignant tumour of urethra" EXACT [DOID:734] +synonym: "malignant urethra neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7507] +synonym: "malignant urethra tumor" EXACT [NCIT:C7507] +synonym: "malignant urethral neoplasm" EXACT [DOID:734, NCIT:C7507] +synonym: "malignant urethral tumor" EXACT [NCIT:C7507] +synonym: "urethra cancer" EXACT [MONDO:patterns/location] +synonym: "urethral Ca" EXACT [DOID:734] +synonym: "urethral cancer" RELATED [ONCOTREE:UCA] +xref: DOID:734 {source="MONDO:equivalentTo"} +xref: GARD:0009390 {source="MONDO:equivalentTo"} +xref: ICD10CM:C68.0 {source="DOID:734", source="MONDO:equivalentTo"} +xref: ICD9:189.3 {source="DOID:734", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7507 {source="DOID:734", source="MONDO:equivalentTo"} +xref: ONCOTREE:UCA {source="MONDO:equivalentTo"} +xref: SCTID:363459007 {source="DOID:734", source="MONDO:equivalentTo"} +is_a: MONDO:0006295 {source="DOID:734", source="ICD10CM:C68.0/inferred", source="MONDO:Redundant", source="NCIT:C7507"} ! malignant urinary system neoplasm +is_a: MONDO:0021239 {source="MONDO:Redundant", source="NCIT:C7507"} ! urethra neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch DOID:734 +property_value: exactMatch http://identifiers.org/snomedct/363459007 +property_value: exactMatch https://icd.codes/icd10cm/C68.0 +property_value: exactMatch NCIT:C7507 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004197 +name: male urethral cancer +def: "A cancer involving a male urethra." [MONDO:patterns/cancer] +synonym: "cancer of male urethra" EXACT [MONDO:patterns/cancer] +synonym: "male urethra cancer" EXACT [MONDO:patterns/location] +synonym: "Male urethral malignant neoplasm" EXACT [NCIT:C39867] +synonym: "malignant male urethra neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of male urethra" EXACT [MONDO:patterns/cancer] +xref: DOID:736 {source="MONDO:equivalentTo"} +xref: NCIT:C39867 {source="DOID:736", source="MONDO:equivalentTo"} +xref: UMLS:C1518164 {source="DOID:736", source="MONDO:equivalentTo", source="NCIT:C39867"} +is_a: MONDO:0004192 {source="DOID:736", source="MONDO:Redundant", source="NCIT:C39867"} ! urethra cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001333 ! male urethra +relationship: disease_has_location UBERON:0001333 ! male urethra +property_value: exactMatch DOID:736 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518164 +property_value: exactMatch NCIT:C39867 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004202 +name: adrenal medulla carcinoma +def: "A carcinoma that arises from epithelial cells of the adrenal medulla" [https://orcid.org/0000-0002-6601-2165] +synonym: "adrenal medulla carcinoma" EXACT [MONDO:patterns/location] +synonym: "carcinoma of adrenal medulla" EXACT [MONDO:patterns/carcinoma] +xref: DOID:7379 {source="MONDO:equivalentTo"} +xref: NCIT:C9276 {source="DOID:7379", source="MONDO:directSiblingOf"} +xref: UMLS:C1334717 {source="DOID:7379", source="MONDO:directSiblingOf"} +is_a: MONDO:0002814 ! adrenal carcinoma +is_a: MONDO:0003606 {source="DOID:7379", source="MONDO:Entailed", source="MONDO:Redundant"} ! adrenal medulla cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001236 ! adrenal medulla +property_value: exactMatch DOID:7379 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004203 +name: female urethral cancer +def: "A cancer that involves the female urethra." [MONDO:patterns/location] +synonym: "cancer of female urethra" EXACT [MONDO:patterns/cancer] +synonym: "female urethra cancer" EXACT [MONDO:patterns/location] +synonym: "female urethral malignant neoplasm" EXACT [NCIT:C39866] +synonym: "malignant female urethra neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of female urethra" EXACT [MONDO:patterns/cancer] +xref: DOID:738 {source="MONDO:equivalentTo"} +xref: NCIT:C39866 {source="DOID:738", source="MONDO:equivalentTo"} +xref: UMLS:C1517154 {source="DOID:738", source="MONDO:equivalentTo", source="NCIT:C39866"} +is_a: MONDO:0004192 {source="DOID:738", source="MONDO:Redundant", source="NCIT:C39866"} ! urethra cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001334 ! female urethra +relationship: disease_has_location UBERON:0001334 ! female urethra +property_value: exactMatch DOID:738 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1517154 +property_value: exactMatch NCIT:C39866 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004235 +name: diverticulitis +def: "An infection that develops in the diverticula of the intestinal tract. Signs and symptoms include abdominal pain, fever, and leukocytosis." [NCIT:C26752] +synonym: "digestive tract diverticulum inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of digestive tract diverticulum" EXACT [] +xref: DOID:7475 {source="MONDO:equivalentTo"} +xref: EFO:1001460 {source="MONDO:equivalentTo"} +xref: MESH:D004238 {source="MONDO:equivalentTo", source="DOID:7475"} +xref: NCIT:C26752 {source="MONDO:equivalentTo", source="NCIT:C26752", source="DOID:7475"} +xref: SCTID:307496006 {source="MONDO:equivalentTo", source="DOID:7475"} +xref: UMLS:C0012813 {source="MONDO:equivalentTo", source="NCIT:C26752", source="DOID:7475"} +is_a: MONDO:0005020 {source="DOID:7475", source="NCIT:C26752/inferred"} ! intestinal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0009854 ! digestive tract diverticulum +relationship: disease_has_feature HP:0002019 {source="MONDO:Wikidata"} ! Constipation +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +relationship: disease_has_feature MONDO:0001517 {source="MONDO:Wikidata"} ! dysentery +relationship: disease_has_feature MONDO:0002203 {source="MONDO:Wikidata"} ! constipation disorder +relationship: disease_has_inflammation_site UBERON:0009854 ! digestive tract diverticulum +property_value: exactMatch DOID:7475 +property_value: exactMatch http://identifiers.org/mesh/D004238 +property_value: exactMatch http://identifiers.org/snomedct/307496006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0012813 +property_value: exactMatch NCIT:C26752 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004245 +name: ependymal tumor of brain +def: "A tumor arising from the ependymal lining of the ventricles." [NCIT:C3861] +synonym: "brain ependymal tumor" EXACT [MONDO:patterns/location] +synonym: "brain ependymoma" RELATED [DOID:7497] +synonym: "ependymal tumor of brain" EXACT [DOID:7497, NCIT:C3861] +synonym: "ependymoma of brain" EXACT [DOID:7497] +xref: DOID:7497 {source="MONDO:equivalentTo"} +xref: NCIT:C3861 {source="MONDO:equivalentTo", source="DOID:7497"} +xref: SCTID:254939008 {source="MONDO:equivalentTo", source="DOID:7497"} +xref: UMLS:C0238029 {source="MONDO:equivalentTo", source="NCIT:C3861", source="DOID:7497"} +is_a: MONDO:0003266 {source="MONDO:Redundant", source="NCIT:C3861"} ! ependymal tumor +is_a: MONDO:0005499 {source="DOID:7497"} ! brain glioma +intersection_of: MONDO:0003266 ! ependymal tumor +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:7497 +property_value: exactMatch http://identifiers.org/snomedct/254939008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238029 +property_value: exactMatch NCIT:C3861 + +[Term] +id: MONDO:0004251 +name: small intestine neoplasm +def: "A benign or malignant neoplasm that affects the small intestine. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma." [NCIT:P378] +synonym: "neoplasm of small bowel" EXACT [NCIT:C4432] +synonym: "neoplasm of small intestine" EXACT [MONDO:patterns/neoplasm, NCIT:C4432] +synonym: "neoplasm of the small bowel" EXACT [NCIT:C4432] +synonym: "neoplasm of the small intestine" EXACT [NCIT:C4432] +synonym: "small bowel neoplasm" EXACT [NCIT:C4432] +synonym: "small bowel tumor" EXACT [NCIT:C4432] +synonym: "small intestinal neoplasm" EXACT [DOID:7505, NCIT:C4432] +synonym: "small intestine neoplasm" EXACT [NCIT:C4432] +synonym: "small intestine neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "small intestine tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4432] +synonym: "tumor of small bowel" EXACT [NCIT:C4432] +synonym: "tumor of small intestine" EXACT [MONDO:patterns/neoplasm, NCIT:C4432] +synonym: "tumor of the small bowel" EXACT [NCIT:C4432] +synonym: "tumor of the small intestine" EXACT [NCIT:C4432] +xref: DOID:7505 {source="MONDO:equivalentTo"} +xref: NCIT:C4432 {source="MONDO:equivalentTo", source="DOID:7505"} +xref: SCTID:126832004 {source="MONDO:equivalentTo", source="DOID:7505"} +xref: UMLS:C0345832 {source="MONDO:equivalentTo", source="NCIT:C4432", source="DOID:7505"} +is_a: MONDO:0021118 {source="DOID:7505", source="MONDO:Redundant", source="NCIT:C4432"} ! intestinal neoplasm +is_a: MONDO:0024635 ! small intestine disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:7505 +property_value: exactMatch http://identifiers.org/snomedct/126832004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345832 +property_value: exactMatch NCIT:C4432 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004255 +name: Wolffian adnexal tumor +def: "A benign or malignant epithelial neoplasm of probable Wolffian origin. It predominantly arises from the broad ligament and presents as a unilateral adnexal mass." [NCIT:C40141] +synonym: "FATWO" RELATED ABBREVIATION [GARD:0008680] +synonym: "female adnexal tumor of probable Wolffian origin" RELATED [GARD:0008680] +synonym: "WAT" RELATED ABBREVIATION [GARD:0008680] +synonym: "Wolffian adenoma" RELATED [GARD:0008680] +synonym: "Wolffian adnexal neoplasm" EXACT [NCIT:C40141] +synonym: "Wolffian adnexal tumor" EXACT [NCIT:C40141] +synonym: "Wolffian tumor" RELATED [GARD:0008680] +xref: DOID:7514 {source="MONDO:equivalentTo"} +xref: GARD:0008680 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: MESH:C536741 {source="DOID:7514", source="MONDO:equivalentTo"} +xref: NCIT:C40141 {source="DOID:7514", source="MONDO:equivalentTo"} +xref: UMLS:C1520159 {source="DOID:7514", source="MONDO:equivalentTo", source="NCIT:C40141"} +is_a: MONDO:0005626 {source="MESH:C536741/inferred", source="MONDO:Redundant", source="NCIT:C40141"} ! epithelial neoplasm +is_a: MONDO:0021629 {source="NCIT:C40141"} ! uterine ligament neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_arises_from_structure UBERON:0003074 ! mesonephric duct +relationship: disease_arises_from_structure UBERON:0003074 ! mesonephric duct +property_value: exactMatch DOID:7514 +property_value: exactMatch http://identifiers.org/mesh/C536741 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1520159 +property_value: exactMatch NCIT:C40141 +property_value: excluded_subClassOf MONDO:0003612 {source="DOID:7514"} + +[Term] +id: MONDO:0004259 +name: endocervical carcinoma +def: "A carcinoma that arises from epithelial cells of the endocervix." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of endocervix" EXACT [DOID:7519, MONDO:patterns/carcinoma, NCIT:C28327] +synonym: "carcinoma of the endocervix" EXACT [DOID:7519, NCIT:C28327] +synonym: "endocervical adenocarcinoma" NARROW [NCIT:C28327] +synonym: "endocervical cancer" EXACT [NCIT:C28327] +synonym: "endocervical carcinoma" EXACT [NCIT:C28327] +synonym: "endocervix carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:7519 {source="MONDO:equivalentTo"} +xref: NCIT:C28327 {source="MONDO:equivalentTo", source="DOID:7519"} +xref: SCTID:372098004 {source="MONDO:equivalentTo", source="DOID:7519"} +xref: UMLS:C1299237 {source="MONDO:equivalentTo", source="DOID:7519", source="NCIT:C28327"} +is_a: MONDO:0005131 {source="DOID:7519", source="MONDO:Redundant", source="NCIT:C28327"} ! cervical carcinoma +is_a: MONDO:0021309 {source="MONDO:Redundant"} ! malignant neoplasm of endocervix +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000458 ! endocervix +property_value: exactMatch DOID:7519 +property_value: exactMatch http://identifiers.org/snomedct/372098004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1299237 +property_value: exactMatch NCIT:C28327 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004265 +name: acute endometritis +def: "An acute, usually bacterial infection affecting the endometrium. It is characterized by the presence of neutrophils or microabscesses in the endometrial glands. Symptoms include fever, lower abdominal pain, and vaginal discharge." [NCIT:P378] +synonym: "endometritis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:7528 {source="MONDO:equivalentTo"} +xref: ICD9:615.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27022 {source="DOID:7528", source="MONDO:equivalentTo"} +xref: SCTID:67667007 {source="DOID:7528", source="MONDO:equivalentTo"} +xref: UMLS:C0238103 {source="NCIT:C27022", source="DOID:7528", source="MONDO:equivalentTo"} +is_a: MONDO:0000918 {source="DOID:7528", source="MONDO:Redundant", source="NCIT:C27022"} ! endometritis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0000918 ! endometritis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:7528 +property_value: exactMatch http://identifiers.org/snomedct/67667007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238103 +property_value: exactMatch NCIT:C27022 + +[Term] +id: MONDO:0004293 +name: supraglottis squamous cell carcinoma +def: "A squamous cell carcinoma of the larynx that arises from the supraglottic area. Signs and symptoms include dysphagia, a sensation of foreign body in the throat, and hemoptysis. It spreads to the space anterior to the epiglottis, pyriform sinus, and base of the tongue." [NCIT:P378] +synonym: "epidermoid carcinoma of supraglottis" EXACT [NCIT:C4945] +synonym: "epidermoid carcinoma of the supraglottis" EXACT [DOID:7587, NCIT:C4945] +synonym: "squamous cell carcinoma of supraglottis" EXACT [NCIT:C4945] +synonym: "squamous cell carcinoma of the supraglottis" EXACT [NCIT:C4945] +synonym: "supraglottic epidermoid carcinoma" EXACT [NCIT:C4945] +synonym: "supraglottic part of larynx squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "supraglottic squamous cell carcinoma" EXACT [NCIT:C4945] +synonym: "supraglottis epidermoid carcinoma" EXACT [NCIT:C4945] +synonym: "supraglottis squamous cell carcinoma" EXACT [NCIT:C4945] +xref: DOID:7587 {source="MONDO:equivalentTo"} +xref: NCIT:C4945 {source="DOID:7587", source="MONDO:equivalentTo"} +xref: UMLS:C0749163 {source="DOID:7587", source="MONDO:equivalentTo", source="NCIT:C4945"} +is_a: MONDO:0004357 {source="DOID:7587", source="MONDO:Redundant", source="NCIT:C4945"} ! carcinoma of supraglottis +is_a: MONDO:0005595 {source="MONDO:Redundant", source="NCIT:C4945"} ! laryngeal squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0036263 ! supraglottic part of larynx +property_value: exactMatch DOID:7587 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0749163 +property_value: exactMatch NCIT:C4945 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0004298 +name: stomach disorder +def: "A disease involving the stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of stomach" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of stomach" EXACT [] +synonym: "disorder of stomach" EXACT [MONDO:patterns/location_top] +synonym: "gastric disease" RELATED [DOID:76] +synonym: "gastropathy" EXACT [DOID:76] +synonym: "stomach disease" EXACT [MONDO:patterns/location] +synonym: "stomach disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "stomach disorder" EXACT [DOID:76, NCIT:C26886] +xref: DOID:76 {source="MONDO:equivalentTo"} +xref: ICD9:537.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:537.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D013272 {source="DOID:76", source="MONDO:equivalentTo"} +xref: NCIT:C26886 {source="DOID:76", source="MONDO:equivalentTo"} +xref: SCTID:29384001 {source="DOID:76", source="MONDO:equivalentTo"} +xref: UMLS:C0038354 {source="DOID:76", source="MONDO:equivalentTo", source="NCIT:C26886"} +is_a: MONDO:0004335 {source="DOID:76", source="MESH:D013272", source="MONDO:Redundant", source="NCIT:C26886"} ! digestive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000945 ! stomach +relationship: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:76 +property_value: exactMatch http://identifiers.org/mesh/D013272 +property_value: exactMatch http://identifiers.org/snomedct/29384001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038354 +property_value: exactMatch NCIT:C26886 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004311 +name: carcinoma of Cowper glands +def: "A carcinoma that involves the bulbo-urethral gland." [MONDO:patterns/location] +synonym: "bulbo-urethral gland carcinoma" EXACT [MONDO:patterns/location] +synonym: "carcinoma of bulbo-urethral gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of Cowper glands" EXACT [NCIT:C39864] +synonym: "Cowper gland carcinoma" RELATED [DOID:7632] +xref: DOID:7632 {source="MONDO:equivalentTo"} +xref: NCIT:C39864 {source="DOID:7632", source="MONDO:equivalentTo"} +xref: UMLS:C1516284 {source="DOID:7632", source="MONDO:equivalentTo", source="NCIT:C39864"} +is_a: MONDO:0003975 {source="MONDO:Redundant", source="NCIT:C39864"} ! Littre gland carcinoma +is_a: MONDO:0005836 ! male reproductive organ cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002366 ! bulbo-urethral gland +relationship: disease_has_location UBERON:0002366 ! bulbo-urethral gland +property_value: exactMatch DOID:7632 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1516284 +property_value: exactMatch NCIT:C39864 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004315 +name: cholangiolocellular carcinoma +def: "An intrahepatic cholangiocarcinoma that arises from the canals of Hering." [NCIT:C41617] +synonym: "cholangiocarcinoma of intralobular bile duct" EXACT [MONDO:design_pattern] +synonym: "cholangiolocellular carcinoma" EXACT [NCIT:C41617] +synonym: "CLC" EXACT ABBREVIATION [NCIT:C41617] +synonym: "intralobular bile duct cholangiocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:7642 {source="MONDO:equivalentTo"} +xref: NCIT:C41617 {source="DOID:7642", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1516490 {source="DOID:7642", source="NCIT:C41617", source="MONDO:equivalentTo"} +is_a: MONDO:0003210 {source="DOID:7642", source="NCIT:C41617"} ! intrahepatic cholangiocarcinoma +is_a: MONDO:0021581 ! connective tissue neoplasm +intersection_of: MONDO:0019087 ! cholangiocarcinoma +intersection_of: disease_has_location UBERON:0001282 ! intralobular bile duct +relationship: disease_has_location UBERON:0001282 ! intralobular bile duct +property_value: exactMatch DOID:7642 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1516490 +property_value: exactMatch NCIT:C41617 + +[Term] +id: MONDO:0004328 +name: maxillary sinus adenocarcinoma +def: "An adenocarcinoma that arises from the maxillary sinus. It is classified as intestinal-type or non-intestinal-type adenocarcinoma. Nasal obstruction and epistaxis are the presenting signs." [NCIT:C6240] +synonym: "adenocarcinoma of maxillary sinus" RELATED [DOID:7684, NCIT:C6240] +synonym: "adenocarcinoma of the maxillary sinus" EXACT [DOID:7684, NCIT:C6240] +synonym: "maxillary sinus adenocarcinoma" EXACT [NCIT:C6240] +xref: DOID:7684 {source="MONDO:equivalentTo"} +xref: NCIT:C6240 {source="MONDO:equivalentTo", source="DOID:7684"} +xref: SCTID:707339009 {source="MONDO:equivalentTo"} +xref: UMLS:C1334642 {source="NCIT:C6240", source="MONDO:equivalentTo", source="DOID:7684"} +is_a: MONDO:0001748 {source="DOID:7684", source="MONDO:Redundant", source="NCIT:C6240", source="NCIT:C6240/inferred"} ! maxillary sinus carcinoma +is_a: MONDO:0004970 {source="DOID:7684/inferred", source="MONDO:Redundant", source="NCIT:C6240/inferred"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001764 ! maxillary sinus +intersection_of: realized_in_response_to_stimulus CL:0000066 ! epithelial cell +relationship: realized_in_response_to_stimulus CL:0000066 ! epithelial cell +property_value: exactMatch DOID:7684 +property_value: exactMatch http://identifiers.org/snomedct/707339009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334642 +property_value: exactMatch NCIT:C6240 + +[Term] +id: MONDO:0004331 +name: bladder urachal adenocarcinoma +def: "A adenocarcinoma that involves the urachus." [MONDO:patterns/location] +subset: gard_rare +synonym: "adenocarcinoma of the urachus" RELATED [GARD:0010186] +synonym: "bladder urachal adenocarcinoma" EXACT [NCIT:C39843] +synonym: "urachal adenocarcinoma" RELATED [ONCOTREE:UA] +synonym: "urachus adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:7694 {source="MONDO:equivalentTo"} +xref: GARD:0010186 {source="MONDO:equivalentTo"} +xref: MESH:C536474 {source="MONDO:equivalentTo"} +xref: NCIT:C39843 {source="MONDO:equivalentTo", source="NCIT:C39843", source="DOID:7694"} +xref: ONCOTREE:UA {source="MONDO:equivalentTo"} +xref: UMLS:C1511204 {source="MONDO:equivalentTo", source="NCIT:C39843", source="DOID:7694"} +is_a: MONDO:0001378 ! urachus cancer +is_a: MONDO:0002751 {source="MONDO:Redundant", source="NCIT:C39843"} ! bladder adenocarcinoma +is_a: MONDO:0003715 {source="DOID:7694", source="NCIT:C39843", source="ONCOTREE:UA"} ! bladder urachal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002068 ! urachus +property_value: exactMatch DOID:7694 +property_value: exactMatch http://identifiers.org/mesh/C536474 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1511204 +property_value: exactMatch NCIT:C39843 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0004335 +name: digestive system disorder +def: "A disease or disorder that involves the digestive system." [MONDO:design_pattern] +synonym: "alimentary system disease" EXACT [DOID:77] +synonym: "digestive disease" EXACT [NCIT:C2990] +synonym: "digestive system disease" EXACT [NCIT:C2990] +synonym: "digestive system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "digestive system disorder" EXACT [DOID:77, NCIT:C2990] +synonym: "disease of digestive system" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of digestive system" EXACT [] +synonym: "disorder of digestive system" EXACT [MONDO:patterns/location_top, NCIT:C2990] +synonym: "gastroenterological system disease" EXACT [MONDO:cjm] +synonym: "gastroenterological system disorder" EXACT [MONDO:cjm] +synonym: "gastroenteropathy" EXACT [DOID:77] +synonym: "gastrointestinal disease" EXACT [DOID:77] +synonym: "gastrointestinal disorder" EXACT [DOID:77, NCIT:C2990] +synonym: "gastrointestinal system disease" EXACT [NCIT:C2990] +synonym: "gastrointestinal system disorder" EXACT [NCIT:C2990] +synonym: "git disease" EXACT [DOID:77] +synonym: "stomach or intestinal disorder" EXACT [NCIT:C2990] +xref: DOID:77 {source="MONDO:equivalentTo"} +xref: EFO:0000405 {source="MONDO:equivalentTo"} +xref: ICD10CM:K00-K95 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:520-579.99 {source="DOID:77"} +xref: ICD9:V47.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005767 {source="MONDO:equivalentTo"} +xref: NCIT:C2990 {source="MONDO:equivalentTo"} +xref: SCTID:53619000 {source="DOID:77", source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +relationship: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +property_value: exactMatch DOID:77 +property_value: exactMatch http://identifiers.org/mesh/D005767 +property_value: exactMatch http://identifiers.org/snomedct/53619000 +property_value: exactMatch https://icd.codes/icd10cm/K00-K95 +property_value: exactMatch NCIT:C2990 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004338 +name: retinal cell cancer +synonym: "cancer of retinal cell" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of retinal cell" EXACT [MONDO:patterns/cancer] +synonym: "malignant retinal cell neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "retinal cell cancer" EXACT [MONDO:patterns/location] +xref: DOID:771 {source="MONDO:equivalentTo"} +is_a: MONDO:0003072 {source="DOID:771", source="MONDO:Redundant"} ! retinal cancer +is_a: MONDO:0024341 ! retinal cell neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_arises_from_structure UBERON:0003902 ! retinal neural layer +property_value: exactMatch DOID:771 + +[Term] +id: MONDO:0004349 +name: retina lymphoma +def: "A lymphoma that involves the retina." [MONDO:patterns/location] +synonym: "lymphoma of retina" EXACT [NCIT:C4365] +synonym: "lymphoma of the retina" EXACT [NCIT:C4365] +synonym: "primary retinal lymphoma" EXACT [NCIT:C4365] +synonym: "retina lymphoma" EXACT [MONDO:patterns/location] +synonym: "retinal lymphoma" EXACT [DOID:774, NCIT:C4365] +xref: DOID:774 {source="MONDO:equivalentTo"} +xref: ICD9:198.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4365 {source="MONDO:equivalentTo", source="DOID:774"} +xref: SCTID:232075002 {source="MONDO:equivalentTo", source="DOID:774"} +xref: UMLS:C0339556 {source="MONDO:equivalentTo", source="NCIT:C4365", source="DOID:774"} +is_a: MONDO:0003072 {source="DOID:774", source="MONDO:Redundant", source="NCIT:C4365"} ! retinal cancer +is_a: MONDO:0004034 {source="DOID:774", source="MONDO:Redundant", source="NCIT:C4365/inferred"} ! eye lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch DOID:774 +property_value: exactMatch http://identifiers.org/snomedct/232075002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339556 +property_value: exactMatch NCIT:C4365 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004357 +name: carcinoma of supraglottis +def: "A carcinoma of the larynx that arises from the supraglottic area." [NCIT:P378] +synonym: "cancer of supraglottis" EXACT [NCIT:C5973] +synonym: "cancer of the supraglottis" EXACT [NCIT:C5973] +synonym: "carcinoma of supraglottic part of larynx" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of supraglottis" EXACT [NCIT:C5973] +synonym: "carcinoma of the supraglottis" EXACT [NCIT:C5973] +synonym: "supraglottic cancer" EXACT [NCIT:C5973] +synonym: "supraglottic carcinoma" EXACT [DOID:7763, NCIT:C5973] +synonym: "supraglottic part of larynx carcinoma" EXACT [MONDO:patterns/location] +synonym: "supraglottic throat cancer" EXACT [NCIT:C5973] +synonym: "supraglottis carcinoma" EXACT [NCIT:C5973] +xref: DOID:7763 {source="MONDO:equivalentTo"} +xref: NCIT:C5973 {source="DOID:7763", source="MONDO:equivalentTo"} +xref: SCTID:372105009 {source="DOID:7763", source="MONDO:equivalentTo"} +xref: UMLS:C1299240 {source="DOID:7763", source="MONDO:equivalentTo", source="NCIT:C5973"} +is_a: MONDO:0001724 {source="DOID:7763", source="MONDO:Redundant", source="NCIT:C5973"} ! supraglottis cancer +is_a: MONDO:0002358 {source="MONDO:Redundant", source="NCIT:C5973"} ! laryngeal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0036263 ! supraglottic part of larynx +property_value: exactMatch DOID:7763 +property_value: exactMatch http://identifiers.org/snomedct/372105009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1299240 +property_value: exactMatch NCIT:C5973 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004382 +name: laryngeal disorder +def: "A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma." [NCIT:P378] +synonym: "disease of larynx" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of larynx" EXACT [] +synonym: "disorder of larynx" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the larynx" EXACT [] +synonym: "laryngeal disease" EXACT [NCIT:C26810] +synonym: "laryngeal disorder" EXACT [NCIT:C26810] +synonym: "larynx disease" EXACT [MONDO:patterns/location] +synonym: "larynx disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:786 {source="MONDO:equivalentTo"} +xref: ICD9:478.70 {source="DOID:786"} +xref: MESH:D007818 {source="DOID:786", source="MONDO:equivalentTo"} +xref: NCIT:C26810 {source="DOID:786", source="MONDO:equivalentTo"} +xref: SCTID:60600009 {source="DOID:786", source="MONDO:equivalentTo"} +xref: UMLS:C0023051 {source="DOID:786", source="MONDO:equivalentTo", source="NCIT:C26810"} +is_a: MONDO:0004867 {source="DOID:786"} ! upper respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001737 ! larynx +relationship: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch DOID:786 +property_value: exactMatch http://identifiers.org/mesh/D007818 +property_value: exactMatch http://identifiers.org/snomedct/60600009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023051 +property_value: exactMatch NCIT:C26810 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004394 +name: maxillary sinus squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal epithelial surface of the maxillary sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis." [NCIT:P378] +synonym: "epidermoid carcinoma of maxillary antrum" EXACT [NCIT:C6064] +synonym: "epidermoid carcinoma of maxillary sinus" EXACT [NCIT:C6064] +synonym: "epidermoid carcinoma of maxillofacial sinus" EXACT [NCIT:C6064] +synonym: "epidermoid carcinoma of the maxillary antrum" EXACT [NCIT:C6064] +synonym: "epidermoid carcinoma of the maxillary sinus" EXACT [NCIT:C6064] +synonym: "epidermoid carcinoma of the maxillofacial sinus" EXACT [DOID:7910, NCIT:C6064] +synonym: "maxillary antrum epidermoid carcinoma" EXACT [NCIT:C6064] +synonym: "maxillary antrum squamous cell carcinoma" EXACT [NCIT:C6064] +synonym: "maxillary sinus epidermoid carcinoma" EXACT [NCIT:C6064] +synonym: "maxillary sinus squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "maxillofacial sinus epidermoid carcinoma" EXACT [NCIT:C6064] +synonym: "maxillofacial sinus squamous cell carcinoma" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of maxillary antrum" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of maxillary sinus" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of maxillofacial sinus" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of the maxillary antrum" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of the maxillary sinus" EXACT [NCIT:C6064] +synonym: "squamous cell carcinoma of the maxillofacial sinus" EXACT [NCIT:C6064] +xref: DOID:7910 {source="MONDO:equivalentTo"} +xref: NCIT:C6064 {source="DOID:7910", source="MONDO:equivalentTo"} +xref: SCTID:707354003 {source="MONDO:equivalentTo"} +xref: UMLS:C1334647 {source="NCIT:C6064", source="DOID:7910", source="MONDO:equivalentTo"} +is_a: MONDO:0001748 {source="DOID:7910", source="MONDO:Redundant", source="NCIT:C6064", source="NCIT:C6064/inferred"} ! maxillary sinus carcinoma +is_a: MONDO:0004958 ! oral cavity squamous cell carcinoma +is_a: MONDO:0044705 ! paranasal sinus squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001764 ! maxillary sinus +property_value: exactMatch DOID:7910 +property_value: exactMatch http://identifiers.org/snomedct/707354003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334647 +property_value: exactMatch NCIT:C6064 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0004398 +name: mediastinal schwannoma +def: "A schwannoma that arises from the posterior mediastinum. It is the most common neurogenic tumor of the mediastinum. Excision is usually curative." [NCIT:C6643] +synonym: "benign mediastinal neurilemmoma" EXACT [NCIT:C6643] +synonym: "benign mediastinal schwannoma" EXACT [NCIT:C6643] +synonym: "benign neurilemmoma of mediastinum" EXACT [NCIT:C6643] +synonym: "benign neurilemmoma of the mediastinum" EXACT [NCIT:C6643] +synonym: "benign schwannoma of mediastinum" EXACT [DOID:7922, NCIT:C6625, NCIT:C6643] +synonym: "benign schwannoma of the mediastinum" EXACT [NCIT:C6643] +synonym: "mediastinal neurilemmoma" EXACT [NCIT:C6643] +synonym: "mediastinal schwannoma" EXACT [NCIT:C6643] +synonym: "mediastinum schwannoma" EXACT [MONDO:patterns/location] +synonym: "neurilemmoma of mediastinum" EXACT [NCIT:C6643] +synonym: "neurilemmoma of the mediastinum" EXACT [NCIT:C6643] +synonym: "schwannoma of mediastinum" EXACT [NCIT:C6643] +synonym: "schwannoma of the mediastinum" EXACT [NCIT:C6643] +xref: DOID:6175 {source="MONDO:equivalentTo"} +xref: DOID:7922 {source="MONDO:equivalentTo"} +xref: NCIT:C6625 {source="DOID:7922", source="MONDO:otherHierarchy"} +xref: NCIT:C6643 {source="MONDO:equivalentTo", source="DOID:6175"} +xref: UMLS:C1334679 {source="MONDO:equivalentTo", source="NCIT:C6643", source="DOID:6175"} +is_a: MONDO:0000638 ! benign glioma +is_a: MONDO:0003098 {source="DOID:6175", source="NCIT:C6643"} ! mediastinal neural neoplasm +is_a: MONDO:0004820 {source="DOID:6175", source="NCIT:C6643"} ! peripheral nerve schwannoma +is_a: MONDO:0021521 {source="MONDO:Entailed", source="NCIT:C6643"} ! benign neoplasm of mediastinum +is_a: MONDO:0056804 ! benign neoplasm of peripheral nervous system +intersection_of: MONDO:0002546 ! schwannoma +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch DOID:6175 +property_value: exactMatch DOID:7922 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334679 +property_value: exactMatch NCIT:C6643 +property_value: relatedMatch NCIT:C6625 + +[Term] +id: MONDO:0004422 +name: cerebral falx meningioma +def: "A meningioma that affects the falx cerebri." [NCIT:P378] +synonym: "Falcine meningioma" EXACT [DOID:7986, NCIT:C5267] +synonym: "falx cerebri meningioma" EXACT [NCIT:C5267] +synonym: "falx cerebri meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "meningioma (disease) of falx cerebri" EXACT [] +synonym: "meningioma of cerebral falx" EXACT [NCIT:C5267] +synonym: "meningioma of falx cerebri" EXACT [NCIT:C5267] +synonym: "meningioma of falx of cerebrum" EXACT [NCIT:C5267] +synonym: "meningioma of the cerebral falx" EXACT [NCIT:C5267] +synonym: "meningioma of the falx cerebri" EXACT [NCIT:C5267] +synonym: "meningioma of the falx of the cerebrum" EXACT [NCIT:C5267] +xref: DOID:7986 {source="MONDO:equivalentTo"} +xref: NCIT:C5267 {source="DOID:7986", source="MONDO:equivalentTo"} +xref: UMLS:C1333597 {source="DOID:7986", source="MONDO:equivalentTo", source="NCIT:C5267"} +is_a: MONDO:0002997 {source="DOID:7986", source="NCIT:C5267"} ! anterior cranial fossa meningioma +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0006059 ! falx cerebri +relationship: disease_has_location UBERON:0006059 ! falx cerebri +property_value: exactMatch DOID:7986 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333597 +property_value: exactMatch NCIT:C5267 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0004427 +name: supraglottis neoplasm +def: "A benign or malignant neoplasm that affects the supraglottic area of the larynx." [NCIT:C6793] +synonym: "neoplasm of supraglottic part of larynx" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of supraglottis" EXACT [NCIT:C6793] +synonym: "neoplasm of the supraglottis" EXACT [NCIT:C6793] +synonym: "supraglottic neoplasm" EXACT [NCIT:C6793] +synonym: "supraglottic part of larynx neoplasm" EXACT [] +synonym: "supraglottic part of larynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "supraglottic part of larynx tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "supraglottic tumor" EXACT [DOID:8002, NCIT:C6793] +synonym: "supraglottis neoplasm" EXACT [NCIT:C6793] +synonym: "supraglottis tumor" EXACT [NCIT:C6793] +synonym: "tumor of supraglottic part of larynx" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of supraglottis" EXACT [NCIT:C6793] +synonym: "tumor of the supraglottis" EXACT [NCIT:C6793] +xref: DOID:8002 {source="MONDO:equivalentTo"} +xref: NCIT:C6793 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:8002"} +xref: SCTID:126697005 {source="MONDO:equivalentTo", source="DOID:8002"} +xref: UMLS:C0345726 {source="NCIT:C6793", source="MONDO:equivalentTo", source="DOID:8002"} +is_a: MONDO:0021071 {source="MONDO:Redundant", source="NCIT:C6793"} ! laryngeal neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0036263 ! supraglottic part of larynx +relationship: disease_has_location UBERON:0036263 ! supraglottic part of larynx +property_value: exactMatch DOID:8002 +property_value: exactMatch http://identifiers.org/snomedct/126697005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345726 +property_value: exactMatch NCIT:C6793 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004429 +name: skin meningioma +def: "A meningioma (disease) that involves the zone of skin." [MONDO:patterns/location] +synonym: "meningioma (disease) of zone of skin" EXACT [] +synonym: "primary meningioma of the skin" NARROW [DOID:8006, NCIT:C5277] +synonym: "zone of skin meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:8006 {source="MONDO:equivalentTo"} +xref: UMLS:C1335481 {source="DOID:8006", source="MONDO:equivalentTo"} +is_a: MONDO:0002898 {source="DOID:8006", source="MONDO:Entailed"} ! skin cancer +is_a: MONDO:0016642 ! meningioma +is_a: MONDO:0021322 ! malignant tumor of meninges +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:8006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335481 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0004440 +name: pineal region meningioma +def: "A meningioma that affects the pineal gland." [NCIT:P378] +synonym: "meningioma (disease) of pineal body" EXACT [] +synonym: "meningioma of pineal area" EXACT [NCIT:C6756] +synonym: "meningioma of pineal gland" EXACT [NCIT:C6756] +synonym: "meningioma of pineal region" EXACT [NCIT:C6756] +synonym: "meningioma of the pineal area" EXACT [NCIT:C6756] +synonym: "meningioma of the pineal gland" EXACT [NCIT:C6756] +synonym: "meningioma of the pineal region" EXACT [NCIT:C6756] +synonym: "pineal area meningioma" EXACT [NCIT:C6756] +synonym: "pineal body meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "pineal gland meningioma" EXACT [NCIT:C6756] +synonym: "pineal meningioma" EXACT [DOID:8031, NCIT:C6756] +xref: DOID:8031 {source="MONDO:equivalentTo"} +xref: NCIT:C6756 {source="MONDO:equivalentTo", source="DOID:8031"} +xref: UMLS:C1335418 {source="MONDO:equivalentTo", source="DOID:8031", source="NCIT:C6756"} +is_a: MONDO:0000642 ! brain meningioma +is_a: MONDO:0021232 {source="MONDO:Redundant", source="NCIT:C6756"} ! pineal body neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0001905 ! pineal body +property_value: exactMatch DOID:8031 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335418 +property_value: exactMatch NCIT:C6756 +property_value: excluded_subClassOf MONDO:0003249 {source="DOID:8031"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0004447 +name: pituitary stalk meningioma +def: "A meningioma that affects the pituitary stalk." [NCIT:P378] +synonym: "meningioma (disease) of pituitary stalk" EXACT [] +synonym: "meningioma of pituitary stalk" EXACT [NCIT:C5311] +synonym: "meningioma of the pituitary stalk" EXACT [DOID:8058, NCIT:C5311] +synonym: "pituitary stalk meningioma (disease)" EXACT [MONDO:patterns/location] +xref: DOID:8058 {source="MONDO:equivalentTo"} +xref: NCIT:C5311 {source="MONDO:equivalentTo", source="DOID:8058"} +xref: UMLS:C1335422 {source="MONDO:equivalentTo", source="NCIT:C5311", source="DOID:8058"} +is_a: MONDO:0000642 ! brain meningioma +is_a: MONDO:0002997 {source="NCIT:C5311"} ! anterior cranial fossa meningioma +is_a: MONDO:0002998 ! skull base meningioma +is_a: MONDO:0003257 ! posterior pituitary gland neoplasm +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0002434 ! pituitary stalk +relationship: disease_has_feature MONDO:0019833 {source="Orphanet:2495-modified"} ! pituitary hormone deficiency from tumoral origin +relationship: disease_has_location UBERON:0002434 ! pituitary stalk +property_value: exactMatch DOID:8058 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335422 +property_value: exactMatch NCIT:C5311 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0004466 +name: neuronitis +comment: Editor note: check this +synonym: "neuroinflammation" RELATED [Wikipedia:Neuroinflammation] +xref: DOID:8117 {source="MONDO:equivalentTo"} +xref: NCIT:C34847 {source="DOID:8117", source="MONDO:equivalentTo"} +xref: UMLS:C0027881 {source="NCIT:C34847", source="DOID:8117", source="MONDO:equivalentTo"} +is_a: MONDO:0005071 {source="DOID:8117/inferred", source="MONDO:Redundant", source="NCIT:C34847/inferred"} ! nervous system disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site CL:0000540 ! neuron +relationship: disease_has_inflammation_site CL:0000540 ! neuron +property_value: exactMatch DOID:8117 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027881 +property_value: exactMatch NCIT:C34847 + +[Term] +id: MONDO:0004471 +name: bacterial arthritis +def: "The inflammation of one or more joints caused by a bacterial infection within the joint space. Symptoms include pain, stiffness, and decreased range of motion in the affected joint." [NCIT:C26699] +synonym: "infectious arthritis" BROAD [DOID:813] +synonym: "pyogenic arthritis" EXACT [NCIT:C26699] +synonym: "septic arthritis" EXACT [NCIT:C26699] +xref: DOID:813 {source="MONDO:equivalentTo"} +xref: EFO:1001351 {source="MONDO:equivalentTo"} +xref: ICD9:711.0 {source="DOID:813"} +xref: ICD9:711.40 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:711.9 {source="DOID:813"} +xref: ICD9:711.90 {source="DOID:813"} +xref: ICD9:711.91 {source="DOID:813"} +xref: ICD9:711.92 {source="DOID:813"} +xref: ICD9:711.93 {source="DOID:813"} +xref: ICD9:711.94 {source="DOID:813"} +xref: ICD9:711.95 {source="DOID:813"} +xref: ICD9:711.96 {source="DOID:813"} +xref: ICD9:711.97 {source="DOID:813"} +xref: MESH:D001170 {source="DOID:813", source="MONDO:equivalentTo"} +xref: NCIT:C26699 {source="MONDO:equivalentTo"} +xref: NCIT:C26700 {source="DOID:813", source="MONDO:directSiblingOf"} +xref: SCTID:48245008 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 ! bacterial infectious disease +is_a: MONDO:0042485 ! infective arthritis +intersection_of: MONDO:0005578 ! arthritic joint disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +property_value: exactMatch DOID:813 +property_value: exactMatch http://identifiers.org/mesh/D001170 +property_value: exactMatch http://identifiers.org/snomedct/48245008 +property_value: exactMatch NCIT:C26699 + +[Term] +id: MONDO:0004473 +name: epiglottis cancer +def: "A malignant neoplasm that affects the epiglottis. The vast majority of cases are squamous cell carcinomas." [NCIT:C4836] +synonym: "cancer of epiglottis" EXACT [MONDO:patterns/cancer] +synonym: "epiglottic cancer" EXACT [DOID:8133, NCIT:C35697] +synonym: "epiglottic carcinoma" NARROW [NCIT:C35697] +synonym: "epiglottic throat cancer" EXACT [NCIT:C35697] +synonym: "epiglottis cancer" EXACT [MONDO:patterns/location] +synonym: "malignant epiglottic neoplasm" EXACT [NCIT:C4836] +synonym: "malignant epiglottic tumor" EXACT [NCIT:C4836] +synonym: "malignant Epiglottis neoplasm" EXACT [NCIT:C4836] +synonym: "malignant epiglottis neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant Epiglottis tumor" EXACT [NCIT:C4836] +synonym: "malignant neoplasm of anterior aspect of epiglottis" NARROW [DOID:8133] +synonym: "malignant neoplasm of anterior epiglottis" EXACT [DOID:8133] +synonym: "malignant neoplasm of anterior surface of epiglottis" NARROW [DOID:8133, MTH:U001374] +synonym: "malignant neoplasm of Epiglottis" EXACT [NCIT:C4836] +synonym: "malignant neoplasm of epiglottis" EXACT [DOID:8133, MONDO:patterns/cancer] +synonym: "malignant neoplasm of the Epiglottis" EXACT [NCIT:C4836] +synonym: "malignant tumor of Epiglottis" EXACT [DOID:8133, NCIT:C4836] +synonym: "malignant tumor of the Epiglottis" EXACT [NCIT:C4836] +xref: DOID:8133 {source="MONDO:equivalentTo"} +xref: ICD10CM:C10.1 {source="MONDO:equivalentTo", source="DOID:8133"} +xref: ICD9:146.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:8133"} +xref: NCIT:C35697 {source="MONDO:equivalentTo", source="DOID:8133"} +xref: NCIT:C4836 {source="MONDO:equivalentTo", source="DOID:8133"} +xref: SCTID:187681002 {source="MONDO:equivalentTo", source="DOID:8133"} +is_a: MONDO:0004109 {source="MONDO:Redundant", source="NCIT:C35697/inferred", source="NCIT:C4836"} ! epiglottis neoplasm +is_a: MONDO:0004357 {source="NCIT:C35697"} ! carcinoma of supraglottis +is_a: MONDO:0005216 ! hypopharyngeal carcinoma +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000388 ! epiglottis +property_value: exactMatch DOID:8133 +property_value: exactMatch http://identifiers.org/snomedct/187681002 +property_value: exactMatch https://icd.codes/icd10cm/C10.1 +property_value: exactMatch NCIT:C35697 +property_value: exactMatch NCIT:C4836 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004474 +name: gallbladder lymphoma +def: "A lymphoma that arises from the gallbladder, with the bulk of the tumor located at this site." [NCIT:C5734] +synonym: "gall bladder lymphoma" EXACT [MONDO:patterns/location] +synonym: "gallbladder lymphoma" EXACT [NCIT:C5734] +synonym: "lymphoma of gall bladder" EXACT [MONDO:design_pattern] +synonym: "lymphoma of gallbladder" EXACT [NCIT:C5734] +synonym: "lymphoma of the gallbladder" EXACT [DOID:8135, NCIT:C5734] +synonym: "primary gallbladder lymphoma" EXACT [NCIT:C5734] +xref: DOID:8135 {source="MONDO:equivalentTo"} +xref: NCIT:C5734 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:8135"} +xref: UMLS:C1333748 {source="MONDO:equivalentTo", source="NCIT:C5734", source="DOID:8135"} +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C5734"} ! gastrointestinal lymphoma +is_a: MONDO:0005411 {source="DOID:8135", source="MONDO:Redundant", source="NCIT:C5734"} ! gallbladder cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:8135 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333748 +property_value: exactMatch NCIT:C5734 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004479 +name: malignant childhood germ cell neoplasm +def: "A malignant germ cell tumor that occurs during childhood." [NCIT:C6541] +synonym: "malignant childhood germ cell neoplasm" EXACT [NCIT:C6541] +synonym: "malignant childhood germ cell tumor" RELATED [NCIT:C6541] +synonym: "malignant pediatric germ cell neoplasm" RELATED [NCIT:C6541] +synonym: "malignant pediatric germ cell tumor" EXACT [DOID:8149, NCIT:C6541] +xref: DOID:8149 {source="MONDO:equivalentTo"} +xref: NCIT:C6541 {source="DOID:8149", source="MONDO:equivalentTo"} +xref: UMLS:C1334574 {source="DOID:8149", source="NCIT:C6541", source="MONDO:equivalentTo"} +is_a: MONDO:0003751 {source="DOID:8149", source="MONDO:Redundant", source="NCIT:C6541"} ! childhood germ cell tumor +is_a: MONDO:0006290 {source="MONDO:Redundant", source="NCIT:C6541"} ! malignant germ cell tumor +is_a: MONDO:0006517 {source="MONDO:Redundant", source="NCIT:C6541"} ! childhood malignant neoplasm +intersection_of: MONDO:0006290 {source="NCIT:C6541"} ! malignant germ cell tumor +intersection_of: MONDO:0006517 {source="NCIT:C6541"} ! childhood malignant neoplasm +property_value: exactMatch DOID:8149 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334574 +property_value: exactMatch NCIT:C6541 + +[Term] +id: MONDO:0004492 +name: mediastinitis +def: "An inflammatory process affecting the mediastinum." [NCIT:C26827] +comment: There is a question whether the inflammation site is the mediastinum itself or the mediastinal pleura. We are using mediastinum here to be consistent with the definition and classification from NCIT. +xref: DOID:819 {source="MONDO:equivalentTo"} +xref: ICD10CM:J98.51 {source="MONDO:equivalentTo"} +xref: ICD9:519.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:819"} +xref: MESH:D008480 {source="MONDO:equivalentTo", source="DOID:819"} +xref: NCIT:C26827 {source="MONDO:equivalentTo", source="DOID:819"} +xref: SCTID:47597000 {source="MONDO:equivalentTo", source="DOID:819"} +xref: UMLS:C0025064 {source="MONDO:equivalentTo", source="DOID:819", source="NCIT:C26827"} +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0021166 ! inflammatory disease +intersection_of: disease_has_inflammation_site UBERON:0003728 ! mediastinum +relationship: disease_has_inflammation_site UBERON:0003728 ! mediastinum +relationship: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch DOID:819 +property_value: exactMatch http://identifiers.org/mesh/D008480 +property_value: exactMatch http://identifiers.org/snomedct/47597000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025064 +property_value: exactMatch https://icd.codes/icd10cm/J98.51 +property_value: exactMatch NCIT:C26827 +property_value: excluded_subClassOf MONDO:0003900 {source="DOID:819"} +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/2198 xsd:string + +[Term] +id: MONDO:0004496 +name: myocarditis +def: "Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak." [https://rarediseases.info.nih.gov/diseases/7137/myocarditis] +subset: gard_rare {source="GARD:0007137"} +synonym: "inflammation of myocardium" EXACT [] +synonym: "myocardial inflammation" EXACT [DOID:820] +synonym: "myocardial inflammation (finding)" EXACT [DOID:820] +synonym: "myocardium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:820 {source="MONDO:equivalentTo"} +xref: GARD:0007137 {source="MONDO:equivalentTo"} +xref: ICD10CM:I40 {source="MONDO:equivalentTo"} +xref: ICD9:429.0 {source="DOID:820", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: KEGG:05416 {source="DOID:820", source="MONDO:relatedTo"} +xref: MESH:D009205 {source="DOID:820", source="MONDO:equivalentTo"} +xref: NCIT:C34831 {source="DOID:820", source="MONDO:equivalentTo"} +xref: SCTID:50920009 {source="DOID:820", source="MONDO:equivalentTo"} +xref: UMLS:C0027059 {source="DOID:820", source="MONDO:equivalentTo", source="NCIT:C34831"} +is_a: MONDO:0000591 {source="Wikipedia:Cardiomyopathy"} ! intrinsic cardiomyopathy +is_a: MONDO:0024636 ! inflammation of heart layer +is_a: MONDO:0024643 ! myocardial disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002349 ! myocardium +relationship: disease_has_inflammation_site UBERON:0002349 ! myocardium +property_value: exactMatch DOID:820 +property_value: exactMatch http://identifiers.org/mesh/D009205 +property_value: exactMatch http://identifiers.org/snomedct/50920009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027059 +property_value: exactMatch https://icd.codes/icd10cm/I40 +property_value: exactMatch NCIT:C34831 +property_value: excluded_subClassOf MONDO:0002824 {source="DOID:820"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7137/myocarditis xsd:anyURI {source="GARD:0007137"} + +[Term] +id: MONDO:0004504 +name: penile urethral cancer +def: "A urethra cancer that involves the penis." [MONDO:patterns/location] +synonym: "penile urethral malignant neoplasm" EXACT [NCIT:C39868] +synonym: "penis urethra cancer" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "urethra cancer of penis" EXACT [MONDO:design_pattern] +xref: DOID:8223 {source="MONDO:equivalentTo"} +xref: NCIT:C39868 {source="MONDO:equivalentTo", source="DOID:8223"} +xref: UMLS:C1518950 {source="MONDO:equivalentTo", source="NCIT:C39868", source="DOID:8223"} +is_a: MONDO:0001325 ! penile cancer +is_a: MONDO:0004197 {source="DOID:8223", source="NCIT:C39868"} ! male urethral cancer +intersection_of: MONDO:0004192 ! urethra cancer +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch DOID:8223 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1518950 +property_value: exactMatch NCIT:C39868 + +[Term] +id: MONDO:0004514 +name: chronic rhinitis +def: "Chronic inflammation of the nasal cavity mucosa. It may lead to post-nasal drip resulting in chronic sore throat and chronic cough." [NCIT:P378] +synonym: "rhinitis - chronic" EXACT [DOID:8252] +synonym: "rhinitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:8252 {source="MONDO:equivalentTo"} +xref: ICD10CM:J31.0 {source="MONDO:equivalentTo", source="DOID:8252"} +xref: ICD9:472.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:8252"} +xref: NCIT:C34479 {source="MONDO:equivalentTo", source="DOID:8252"} +xref: SCTID:86094006 {source="MONDO:equivalentTo", source="DOID:8252"} +xref: UMLS:C0008711 {source="MONDO:equivalentTo", source="NCIT:C34479", source="DOID:8252"} +is_a: MONDO:0003014 {source="DOID:8252", source="MONDO:Redundant", source="NCIT:C34479"} ! rhinitis +intersection_of: MONDO:0003014 ! rhinitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: disease_has_feature HP:0002257 ! Chronic rhinitis +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:8252 +property_value: exactMatch http://identifiers.org/snomedct/86094006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008711 +property_value: exactMatch https://icd.codes/icd10cm/J31.0 +property_value: exactMatch NCIT:C34479 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0004522 +name: peritonitis +def: "Inflammation of the peritoneum due to infection by bacteria or fungi. Causes include liver disease, perforation of the gastrointestinal tract or biliary tract, and peritoneal dialysis. Patients usually present with abdominal pain and tenderness, fever, chills, and nausea and vomiting. It is an emergency medical condition that requires prompt medical attention and treatment." [NCIT:C26849] +synonym: "acute generalized peritonitis" EXACT [DOID:8283] +synonym: "inflammation of peritoneum" EXACT [] +synonym: "peritoneum inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "primary bacterial peritonitis" EXACT [DOID:8283] +synonym: "retractile mesenteritis" EXACT [DOID:8283] +xref: DOID:8283 {source="MONDO:equivalentTo"} +xref: EFO:0008588 {source="MONDO:equivalentTo"} +xref: ICD9:567.8 {source="DOID:8283"} +xref: ICD9:567.82 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:567.89 {source="DOID:8283"} +xref: NCIT:C26849 {source="MONDO:equivalentTo"} +xref: SCTID:86422009 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 {source="DOID:8283", source="EFO:0008588"} ! digestive system disorder +is_a: MONDO:0043786 ! serositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002358 ! peritoneum +relationship: disease_has_inflammation_site UBERON:0002358 ! peritoneum +property_value: exactMatch DOID:8283 +property_value: exactMatch http://identifiers.org/snomedct/86422009 +property_value: exactMatch NCIT:C26849 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004532 +name: auditory system cancer +def: "A malignant neoplasm involving the auditory system" [https://orcid.org/0000-0002-6601-2165] +synonym: "auditory system cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of auditory system" EXACT [MONDO:patterns/cancer] +synonym: "malignant auditory system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of auditory system" EXACT [MONDO:patterns/cancer] +xref: DOID:833 {source="MONDO:equivalentTo"} +is_a: MONDO:0000649 {source="DOID:833", source="MONDO:Entailed", source="MONDO:Redundant"} ! sensory system cancer +is_a: MONDO:0002409 {source="DOID:833", source="MONDO:Entailed", source="MONDO:Redundant"} ! auditory system disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0016490 ! auditory system +property_value: exactMatch DOID:833 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004539 +name: aortic malignant tumor +def: "A cancer that involves the aorta." [MONDO:patterns/location] +synonym: "aorta cancer" EXACT [] +synonym: "aortic malignant neoplasm" EXACT [DOID:8352] +synonym: "cancer of aorta" EXACT [MONDO:patterns/cancer] +synonym: "malignant aorta neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant aortic neoplasm" EXACT [NCIT:C5375] +synonym: "malignant neoplasm of aorta" EXACT [MONDO:patterns/cancer, NCIT:C5375] +synonym: "malignant neoplasm of the aorta" EXACT [NCIT:C5375] +synonym: "malignant tumor of aorta" EXACT [NCIT:C5375] +synonym: "malignant tumor of the aorta" EXACT [NCIT:C5375] +xref: DOID:8352 {source="MONDO:equivalentTo"} +xref: NCIT:C5375 {source="MONDO:equivalentTo", source="DOID:8352"} +xref: UMLS:C1334560 {source="NCIT:C5375", source="MONDO:equivalentTo", source="DOID:8352"} +is_a: MONDO:0005561 ! aortic disorder +is_a: MONDO:0040676 ! great vessel cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000947 ! aorta +property_value: exactMatch DOID:8352 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334560 +property_value: exactMatch NCIT:C5375 +property_value: excluded_subClassOf MONDO:0002095 {source="DOID:8352"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004565 +name: intestinal obstruction +def: "Blockage of the normal flow of the intestinal contents within the bowel." [NCIT:P378] +synonym: "bowel obstruction" EXACT [NCIT:C9175] +xref: DOID:8437 {source="MONDO:equivalentTo"} +xref: ICD9:560.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:560.9 {source="DOID:8437", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D007415 {source="DOID:8437", source="MONDO:equivalentTo"} +xref: NCIT:C9175 {source="DOID:8437", source="MONDO:equivalentTo", source="MONDO:otherHierarchy"} +xref: SCTID:81060008 {source="DOID:8437", source="MONDO:equivalentTo"} +xref: UMLS:C0021843 {source="DOID:8437", source="MONDO:equivalentTo"} +is_a: MONDO:0005020 {source="DOID:8437", source="MESH:D007415"} ! intestinal disorder +property_value: exactMatch DOID:8437 +property_value: exactMatch http://identifiers.org/mesh/D007415 +property_value: exactMatch http://identifiers.org/snomedct/81060008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0021843 +property_value: exactMatch NCIT:C9175 + +[Term] +id: MONDO:0004582 +name: rheumatic myocarditis +def: "Inflammation of the myocardium in acute rheumatic heart disease." [NCIT:C35202] +synonym: "active rheumatic fever with myocarditis" EXACT [DOID:8481] +synonym: "acute rheumatic carditis" EXACT [DOID:8481] +synonym: "acute rheumatic myocarditis" EXACT [DOID:8481, ICD9CM:391.2, NCIT:C35202] +synonym: "acute rheumatic myocarditis (disorder) [ambiguous]" EXACT [DOID:8481] +synonym: "rheumatic degeneration of myocardium" EXACT [DOID:8481] +synonym: "rheumatic fever with myocarditis" EXACT [DOID:8481] +synonym: "rheumatic myocarditis" EXACT [DOID:8481, ICD9CM:398.0] +synonym: "rheumatoid myocarditis" EXACT [DOID:8481] +xref: DOID:8481 {source="MONDO:equivalentTo"} +xref: ICD9:391.9 {source="DOID:8481"} +xref: ICD9:398.0 {source="DOID:8481"} +xref: NCIT:C35202 {source="MONDO:equivalentTo"} +xref: SCTID:195136004 {source="MONDO:equivalentTo", source="DOID:8481"} +xref: UMLS:C0155557 {source="MONDO:equivalentTo"} +is_a: MONDO:0004496 ! myocarditis +is_a: MONDO:0006955 {source="DOID:8481", source="NCIT:C35202/inferred"} ! rheumatic heart disease +intersection_of: MONDO:0004496 ! myocarditis +intersection_of: disease_arises_from_feature MONDO:0008383 ! rheumatoid arthritis +relationship: disease_arises_from_feature MONDO:0008383 ! rheumatoid arthritis +property_value: exactMatch DOID:8481 +property_value: exactMatch http://identifiers.org/snomedct/195136004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155557 +property_value: exactMatch NCIT:C35202 + +[Term] +id: MONDO:0004586 +name: rheumatoid lung disease +def: "Rheumatoid lung disease is a group of lung problems related to rheumatoid arthritis." [https://medlineplus.gov/ency/article/000113.htm, PMID:17684286] +synonym: "rheumatoid lung" EXACT [DOID:849] +xref: DOID:849 {source="MONDO:equivalentTo"} +xref: ICD9:714.81 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:849"} +xref: SCTID:398726004 {source="MONDO:equivalentTo", source="DOID:849"} +xref: UMLS:C0994344 {source="MONDO:equivalentTo"} +is_a: MONDO:0005275 {source="DOID:849", source="MONDO:Redundant"} ! lung disorder +is_a: MONDO:0007179 {source="DOID:849", source="MONDO:Redundant"} ! autoimmune disease +intersection_of: MONDO:0005275 ! lung disorder +intersection_of: disease_arises_from_feature MONDO:0008383 ! rheumatoid arthritis +relationship: disease_arises_from_feature MONDO:0008383 ! rheumatoid arthritis +property_value: exactMatch DOID:849 +property_value: exactMatch http://identifiers.org/snomedct/398726004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0994344 + +[Term] +id: MONDO:0004603 +name: collagenopathy +is_a: MONDO:0003900 ! connective tissue disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005581 ! collagen trimer +relationship: disease_has_basis_in_dysfunction_of GO:0005581 ! collagen trimer +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0004608 +name: oropharynx cancer +def: "A primary or metastatic malignant neoplasm that affects the oropharynx." [NCIT:C7398] +synonym: "cancer of oropharynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of junctional region of oropharynx" EXACT [DOID:8557] +synonym: "malignant neoplasm of lateral wall of oropharynx" EXACT [DOID:8557, MTH:U000704] +synonym: "malignant neoplasm of oropharynx" EXACT [DOID:8557, MONDO:patterns/cancer, MTH:NOCODE, NCIT:C7398] +synonym: "malignant neoplasm of posterior wall of oropharynx" EXACT [DOID:8557] +synonym: "malignant neoplasm of the oropharynx" EXACT [NCIT:C7398] +synonym: "malignant oropharyngeal neoplasm" EXACT [NCIT:C7398] +synonym: "malignant oropharyngeal tumor" EXACT [DOID:8557, NCIT:C7398] +synonym: "malignant oropharynx neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of oropharynx" EXACT [NCIT:C7398] +synonym: "malignant tumor of posterior wall of oropharynx" EXACT [DOID:8557] +synonym: "malignant tumor of the oropharynx" EXACT [NCIT:C7398] +synonym: "malignant tumour of mesopharynx" EXACT [DOID:8557] +synonym: "oropharyngeal cancer" EXACT [DOID:8557] +synonym: "oropharyngeal carcinoma" NARROW [DOID:8557, NCIT:C9105] +synonym: "oropharynx cancer" EXACT [MONDO:patterns/location] +synonym: "primary malignant neoplasm of lateral wall of oropharynx" EXACT [DOID:8557] +xref: DOID:8557 {source="MONDO:equivalentTo"} +xref: EFO:1001931 {source="MONDO:equivalentTo"} +xref: GARD:0009358 {source="MONDO:equivalentTo"} +xref: ICD10CM:C10 {source="DOID:8557", source="MONDO:equivalentTo"} +xref: ICD9:146 {source="DOID:8557"} +xref: ICD9:146.5 {source="DOID:8557"} +xref: ICD9:146.6 {source="DOID:8557"} +xref: ICD9:146.7 {source="DOID:8557"} +xref: ICD9:146.9 {source="DOID:8557"} +xref: MESH:D009959 {source="MONDO:equivalentTo"} +xref: NCIT:C7398 {source="DOID:8557", source="MONDO:equivalentTo"} +xref: UMLS:C0153382 {source="NCIT:C7398", source="DOID:8557", source="MONDO:equivalentTo"} +xref: UMLS:C0153389 {source="DOID:8557", source="MONDO:equivalentTo"} +xref: UMLS:C0153390 {source="DOID:8557", source="MONDO:equivalentTo"} +xref: UMLS:C2349952 {source="MONDO:equivalentTo"} +xref: UMLS:C3165521 {source="MONDO:equivalentTo"} +is_a: MONDO:0005517 {source="DOID:8557", source="EFO:1001931", source="MESH:D009959", source="MONDO:Redundant", source="NCIT:C7398"} ! pharynx cancer +is_a: MONDO:0021364 {source="MONDO:Redundant", source="NCIT:C7398"} ! neoplasm of oropharynx +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001729 ! oropharynx +property_value: exactMatch DOID:8557 +property_value: exactMatch http://identifiers.org/mesh/D009959 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153382 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153389 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153390 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2349952 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3165521 +property_value: exactMatch https://icd.codes/icd10cm/C10 +property_value: exactMatch NCIT:C7398 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004609 +name: herpes simplex infectious disease +def: "A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)" [MESH:D006561] +synonym: "herpes simplex" RELATED [] +synonym: "herpes simplex complex" RELATED [] +synonym: "herpes simplex infection" RELATED [] +synonym: "herpes simplex viral infection" RELATED [] +synonym: "Herpesvirus hominis disease" EXACT [DOID:8566] +synonym: "Simplexvirus caused disease or disorder" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Simplexvirus disease or disorder" EXACT [] +synonym: "Simplexvirus infectious disease" EXACT [] +xref: DOID:8566 {source="MONDO:equivalentTo"} +xref: EFO:1002022 {source="MONDO:equivalentTo"} +xref: ICD10CM:B00 {source="DOID:8566", source="MONDO:equivalentTo"} +xref: ICD9:054 {source="DOID:8566"} +xref: ICD9:058.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006561 {source="DOID:8566", source="MONDO:equivalentTo"} +xref: SCTID:88594005 {source="DOID:8566", source="MONDO:equivalentTo"} +xref: UMLS:C0019348 {source="DOID:8566", source="MONDO:equivalentTo"} +is_a: MONDO:0005794 {source="MESH:D006561", source="MONDO:Redundant"} ! Herpesviridae infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +relationship: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +property_value: exactMatch DOID:8566 +property_value: exactMatch http://identifiers.org/mesh/D006561 +property_value: exactMatch http://identifiers.org/snomedct/88594005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019348 +property_value: exactMatch https://icd.codes/icd10cm/B00 + +[Term] +id: MONDO:0004611 +name: soft palate cancer +def: "A primary or metastatic malignant neoplasm that affects the soft palate." [NCIT:C3529] +synonym: "cancer of soft palate" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of soft palate" EXACT [MONDO:patterns/cancer, NCIT:C3529] +synonym: "malignant neoplasm of the soft palate" EXACT [NCIT:C3529] +synonym: "malignant soft palate neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3529] +synonym: "malignant soft palate tumor" EXACT [NCIT:C3529] +synonym: "malignant tumor of soft palate" EXACT [NCIT:C3529] +synonym: "malignant tumor of the soft palate" EXACT [DOID:8578, NCIT:C3529] +synonym: "soft palate cancer" EXACT [MONDO:patterns/location] +xref: DOID:8578 {source="MONDO:equivalentTo"} +xref: ICD10CM:C05.1 {source="DOID:8578", source="MONDO:equivalentTo"} +xref: ICD9:145.3 {source="DOID:8578", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3529 {source="DOID:8578", source="MONDO:equivalentTo"} +xref: SCTID:363388009 {source="DOID:8578", source="MONDO:equivalentTo"} +xref: UMLS:C0153376 {source="DOID:8578", source="NCIT:C3529", source="MONDO:equivalentTo"} +is_a: MONDO:0004608 {source="NCIT:C3529"} ! oropharynx cancer +is_a: MONDO:0005286 ! palatal neoplasm +is_a: MONDO:0005515 {source="DOID:8578", source="MONDO:Redundant", source="NCIT:C3529/inferred"} ! oral cavity cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001733 ! soft palate +relationship: disease_has_location UBERON:0001733 ! soft palate +property_value: exactMatch DOID:8578 +property_value: exactMatch http://identifiers.org/snomedct/363388009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153376 +property_value: exactMatch https://icd.codes/icd10cm/C05.1 +property_value: exactMatch NCIT:C3529 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004615 +name: upper gum cancer +def: "A cancer involving a gingiva of upper jaw." [MONDO:patterns/cancer] +synonym: "cancer of gingiva of upper jaw" EXACT [MONDO:patterns/cancer] +synonym: "gingiva of upper jaw cancer" EXACT [MONDO:patterns/location] +synonym: "malignant gingiva of upper jaw neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of gingiva of upper jaw" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of upper gingiva" EXACT [DOID:8601, MTH:U001011] +synonym: "malignant tumour of upper gum" EXACT [DOID:8601] +xref: DOID:8601 {source="MONDO:equivalentTo"} +xref: ICD9:143.0 {source="DOID:8601", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:363383000 {source="DOID:8601", source="MONDO:equivalentTo"} +xref: UMLS:C0153365 {source="DOID:8601", source="MONDO:equivalentTo"} +is_a: MONDO:0005507 {source="DOID:8601", source="MONDO:Redundant"} ! gingival cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0011601 ! gingiva of upper jaw +relationship: disease_has_location UBERON:0011601 ! gingiva of upper jaw +property_value: exactMatch DOID:8601 +property_value: exactMatch http://identifiers.org/snomedct/363383000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153365 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004617 +name: recurrent hypersomnia +def: "Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., idiopathic hypersomnolence; narcolepsy; and kleine-levin syndrome) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, mental disorders, and sleep apnea syndrome). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)" [MESH:D006970] +synonym: "primary recurrent hypersomnia" EXACT [DOID:8619] +xref: DOID:8619 {source="MONDO:equivalentTo"} +xref: ICD10CM:G47.13 {source="MONDO:equivalentTo", source="DOID:8619"} +xref: ICD9:327.13 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:8619"} +xref: SCTID:426451004 {source="MONDO:equivalentTo", source="DOID:8619"} +xref: UMLS:C0751226 {source="MONDO:equivalentTo", source="DOID:8619"} +is_a: MONDO:0003406 {source="DOID:8619", source="ICD10CM:G47.13", source="ICD10CM:G47.13/inferred"} ! sleep-wake disorder +property_value: exactMatch DOID:8619 +property_value: exactMatch http://identifiers.org/snomedct/426451004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751226 +property_value: exactMatch https://icd.codes/icd10cm/G47.13 + +[Term] +id: MONDO:0004621 +name: upper lip cancer +def: "A malignant neoplasm involving the upper lip." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of upper lip" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of upper lip" EXACT [MONDO:patterns/cancer] +synonym: "malignant upper lip neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "upper lip cancer" EXACT [MONDO:patterns/location] +xref: DOID:8630 {source="MONDO:equivalentTo"} +xref: ICD9:140.0 {source="DOID:8630"} +xref: ICD9:140.3 {source="DOID:8630"} +is_a: MONDO:0006834 {source="DOID:8630", source="MONDO:Redundant"} ! lip cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001834 ! upper lip +relationship: disease_has_location UBERON:0001834 ! upper lip +property_value: exactMatch DOID:8630 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004624 +name: uvula cancer +def: "A malignant neoplasm involving the palatine uvula." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of palatine uvula" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of palatine uvula" EXACT [MONDO:patterns/cancer] +synonym: "malignant palatine uvula neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of uvula" EXACT [DOID:8635] +synonym: "malignant uvula neoplasm" EXACT [NCIT:C35177] +synonym: "malignant uvula tumor" EXACT [NCIT:C35177] +synonym: "malignant uvula tumour" EXACT [NCIT:C35177] +synonym: "malignant uvular neoplasm" EXACT [NCIT:C35177] +synonym: "malignant uvular tumor" EXACT [DOID:8635, NCIT:C35177] +synonym: "malignant uvular tumour" EXACT [NCIT:C35177] +synonym: "palatine uvula cancer" EXACT [MONDO:patterns/location] +xref: DOID:8635 {source="MONDO:equivalentTo"} +xref: ICD9:145.4 {source="DOID:8635", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35177 {source="DOID:8635", source="MONDO:equivalentTo"} +xref: SCTID:363389001 {source="DOID:8635", source="MONDO:equivalentTo"} +xref: UMLS:C0153377 {source="DOID:8635", source="NCIT:C35177", source="MONDO:equivalentTo"} +is_a: MONDO:0004611 {source="DOID:8635", source="MONDO:Redundant", source="NCIT:C35177"} ! soft palate cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001734 ! palatine uvula +relationship: disease_has_location UBERON:0001734 ! palatine uvula +property_value: exactMatch DOID:8635 +property_value: exactMatch http://identifiers.org/snomedct/363389001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153377 +property_value: exactMatch NCIT:C35177 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004625 +name: phlebitis +def: "Inflammation of a vein." [NCIT:P378] +synonym: "inflammation of vein" EXACT [] +synonym: "vein inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:864 {source="MONDO:equivalentTo"} +xref: EFO:1001395 {source="MONDO:equivalentTo"} +xref: MESH:D010689 {source="DOID:864", source="MONDO:equivalentTo"} +xref: NCIT:C38003 {source="DOID:864", source="MONDO:equivalentTo"} +xref: SCTID:61599003 {source="DOID:864", source="MONDO:equivalentTo"} +is_a: MONDO:0004634 {source="DOID:864", source="MONDO:Redundant"} ! vein disorder +is_a: MONDO:0018882 ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001638 ! vein +relationship: disease_has_inflammation_site UBERON:0001638 ! vein +property_value: exactMatch DOID:864 +property_value: exactMatch http://identifiers.org/mesh/D010689 +property_value: exactMatch http://identifiers.org/snomedct/61599003 +property_value: exactMatch NCIT:C38003 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004627 +name: duodenitis +def: "Acute or chronic inflammation of the duodenum. Causes include bacterial and viral infections and gastroesophageal reflux disease. Symptoms include vomiting and abdominal pain." [NCIT:P378] +synonym: "duodenitis" EXACT [] +synonym: "duodenum inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "hemorrhagic duodenitis" NARROW [DOID:8643, MTH:NOCODE] +synonym: "inflammation of duodenum" EXACT [] +xref: DOID:8643 {source="MONDO:equivalentTo"} +xref: ICD10CM:K29.8 {source="DOID:8643", source="MONDO:equivalentTo"} +xref: ICD9:535.6 {source="DOID:8643"} +xref: ICD9:535.60 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D004382 {source="DOID:8643", source="MONDO:equivalentTo"} +xref: NCIT:C94409 {source="DOID:8643", source="MONDO:equivalentTo"} +xref: SCTID:72007001 {source="DOID:8643", source="MONDO:equivalentTo"} +xref: UMLS:C0013298 {source="DOID:8643", source="MONDO:equivalentTo", source="NCIT:C94409"} +is_a: MONDO:0002866 {source="MESH:D004382", source="MONDO:Redundant"} ! duodenal disorder +is_a: MONDO:0043579 ! enteritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002114 ! duodenum +relationship: disease_has_inflammation_site UBERON:0002114 ! duodenum +property_value: exactMatch DOID:8643 +property_value: exactMatch http://identifiers.org/mesh/D004382 +property_value: exactMatch http://identifiers.org/snomedct/72007001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013298 +property_value: exactMatch https://icd.codes/icd10cm/K29.8 +property_value: exactMatch NCIT:C94409 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004630 +name: substance-induced psychosis +xref: DOID:8646 {source="MONDO:equivalentTo"} +xref: ICD9:293.89 {source="DOID:8646"} +is_a: MONDO:0005485 {source="DOID:8646", source="MONDO:cjm"} ! psychotic disorder +property_value: exactMatch DOID:8646 + +[Term] +id: MONDO:0004631 +name: tongue cancer +def: "A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas." [NCIT:C9345] +subset: gard_rare {source="GARD:0007779"} +synonym: "cancer of tongue" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of anterior 2/3 of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of anterior two-thirds of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of anterior two-thirds of tongue, part unspecified" NARROW [DOID:8649] +synonym: "malignant neoplasm of base of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of border of tongue" NARROW [DOID:8649, MTH:U001371] +synonym: "malignant neoplasm of dorsal surface of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of dorsal tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of dorsal tongue NOS" NARROW [DOID:8649] +synonym: "malignant neoplasm of dorsum of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of fixed part of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of fixed part of tongue NOS" NARROW [DOID:8649] +synonym: "malignant neoplasm of junctional zone of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of lingual tonsil" RELATED DUBIOUS [DOID:8649] +synonym: "malignant neoplasm of mobile part of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of mobile part of tongue NOS" NARROW [DOID:8649] +synonym: "malignant neoplasm of other sites of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of the tongue" NARROW [NCIT:C9345] +synonym: "malignant neoplasm of tip and lateral border of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of tip and/or lateral border of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of tongue" EXACT [DOID:8649, ICD9CM:141, MONDO:patterns/cancer, MTH:NOCODE, NCIT:C9345] +synonym: "malignant neoplasm of tongue NOS" NARROW [DOID:8649] +synonym: "malignant neoplasm of tongue, NOS" NARROW [DOID:8649] +synonym: "malignant neoplasm of tongue, tip and lateral border" NARROW [DOID:8649] +synonym: "malignant neoplasm of ventral surface of tongue" NARROW [DOID:8649] +synonym: "malignant neoplasm of ventral tongue surface" NARROW [DOID:8649] +synonym: "malignant tongue neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9345] +synonym: "malignant tongue tumor" EXACT [NCIT:C9345] +synonym: "malignant tumor of anterior two-thirds of tongue" NARROW [DOID:8649] +synonym: "malignant tumor of base of tongue" NARROW [DOID:8649] +synonym: "malignant tumor of lingual tonsil" NARROW DUBIOUS [DOID:8649, MTH:U001010] +synonym: "malignant tumor of lingual tonsil (disorder)" RELATED DUBIOUS [DOID:8649] +synonym: "malignant tumor of mobile part of tongue" NARROW [DOID:8649] +synonym: "malignant tumor of posterior tongue" NARROW [DOID:8649, NCIT:C3524] +synonym: "malignant tumor of the tongue" EXACT [NCIT:C9345] +synonym: "malignant tumor of tongue" EXACT [NCIT:C9345] +synonym: "tongue cancer" EXACT [MONDO:patterns/location] +synonym: "tongue carcinoma" RELATED [GARD:0007779] +synonym: "tongue neoplasm malignant" EXACT [DOID:8649] +synonym: "tongue neoplasm malignant stage unspecified" NARROW [DOID:8649, NCIT:C9345] +synonym: "tongue neoplasm, malignant" EXACT [NCIT:C9345] +xref: DOID:8649 {source="MONDO:equivalentTo"} +xref: GARD:0007779 {source="MONDO:equivalentTo"} +xref: ICD9:141 {source="DOID:8649"} +xref: ICD9:141.0 {source="DOID:8649"} +xref: ICD9:141.1 {source="DOID:8649"} +xref: ICD9:141.2 {source="DOID:8649"} +xref: ICD9:141.3 {source="DOID:8649"} +xref: ICD9:141.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:141.5 {source="DOID:8649"} +xref: ICD9:141.6 {source="DOID:8649"} +xref: ICD9:141.9 {source="DOID:8649"} +xref: MESH:D014062 {source="MONDO:equivalentTo", source="DOID:8649"} +xref: NCIT:C9345 {source="MONDO:equivalentTo", source="DOID:8649"} +xref: SCTID:363360003 {source="MONDO:equivalentTo"} +is_a: MONDO:0000649 ! sensory system cancer +is_a: MONDO:0005515 {source="DOID:8649", source="NCIT:C9345"} ! oral cavity cancer +is_a: MONDO:0021240 {source="MONDO:Redundant", source="NCIT:C9345"} ! tongue neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001723 ! tongue +property_value: exactMatch DOID:8649 +property_value: exactMatch http://identifiers.org/mesh/D014062 +property_value: exactMatch http://identifiers.org/snomedct/363360003 +property_value: exactMatch NCIT:C9345 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7779/tongue-cancer xsd:anyURI {source="GARD:0007779"} + +[Term] +id: MONDO:0004634 +name: vein disorder +def: "A disease involving the vein." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of vein" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vein" EXACT [] +synonym: "disorder of vein" EXACT [MONDO:patterns/location_top] +synonym: "vein disease" EXACT [MONDO:patterns/location] +synonym: "vein disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:866 {source="MONDO:equivalentTo"} +xref: ICD9:453 {source="DOID:866"} +xref: SCTID:90507008 {source="MONDO:equivalentTo"} +xref: UMLS:C0235522 {source="MONDO:equivalentTo"} +is_a: MONDO:0005385 {source="DOID:866", source="MONDO:Redundant"} ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001638 ! vein +relationship: disease_has_location UBERON:0001638 ! vein +property_value: exactMatch DOID:866 +property_value: exactMatch http://identifiers.org/snomedct/90507008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235522 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004640 +name: alcoholic gastritis +def: "Inflammation of the stomach resulting from alcohol ingestion." [NCIT:C26977] +synonym: "alcoholic gastritis" EXACT [DOID:8680, NCIT:C26977] +synonym: "alcoholic gastritis, with hemorrhage" EXACT [DOID:8680] +synonym: "alcoholic gastritis, without mention of hemorrhage" EXACT [DOID:8680] +xref: DOID:8680 {source="MONDO:equivalentTo"} +xref: ICD10CM:K29.2 {source="MONDO:equivalentTo", source="DOID:8680"} +xref: ICD9:535.3 {source="DOID:8680"} +xref: ICD9:535.30 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C26977 {source="MONDO:equivalentTo", source="DOID:8680"} +xref: SCTID:2043009 {source="MONDO:equivalentTo", source="DOID:8680"} +xref: UMLS:C0156076 {source="MONDO:equivalentTo", source="DOID:8680", source="NCIT:C26977"} +is_a: MONDO:0004966 {source="DOID:8680", source="MONDO:Redundant", source="NCIT:C26977"} ! gastritis +intersection_of: MONDO:0004966 ! gastritis +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +relationship: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:8680 +property_value: exactMatch http://identifiers.org/snomedct/2043009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0156076 +property_value: exactMatch https://icd.codes/icd10cm/K29.2 +property_value: exactMatch NCIT:C26977 + +[Term] +id: MONDO:0004650 +name: malignant carotid body paraganglioma +def: "A carotid body paraganglioma that metastasizes to other anatomic sites." [NCIT:C3574] +synonym: "cancer of carotid body" RELATED [DOID:8731] +synonym: "carotid body cancer" RELATED [DOID:8731] +synonym: "carotid body paraganglioma, malignant" EXACT [MONDO:patterns/malignant] +synonym: "chemodectoma, malignant" RELATED [NCIT:C3574] +synonym: "malignant carotid body neoplasm" RELATED [NCIT:C3574] +synonym: "malignant carotid body paraganglioma" EXACT [DOID:8731, NCIT:C3574] +synonym: "malignant carotid body tumor" RELATED [NCIT:C3574] +synonym: "malignant carotid body tumor (morphologic abnormality)" EXACT [DOID:8731] +synonym: "malignant neoplasm of carotid body" RELATED [NCIT:C3574] +synonym: "malignant neoplasm of the carotid body" RELATED [NCIT:C3574] +synonym: "malignant tumor of carotid body" RELATED [NCIT:C3574] +synonym: "malignant tumor of the carotid body" RELATED [NCIT:C3574] +xref: DOID:8731 {source="MONDO:equivalentTo"} +xref: ICD10CM:C75.4 {source="DOID:8731", source="MONDO:equivalentTo"} +xref: ICD9:194.5 {source="DOID:8731", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3574 {source="DOID:8731", source="MONDO:equivalentTo"} +xref: SCTID:447883002 {source="DOID:8731", source="MONDO:equivalentTo"} +xref: UMLS:C0153656 {source="DOID:8731", source="MONDO:equivalentTo", source="NCIT:C3574"} +is_a: MONDO:0002095 ! vascular cancer +is_a: MONDO:0002714 ! central nervous system cancer +is_a: MONDO:0005627 {source="MONDO:Redundant", source="NCIT:C3574"} ! head and neck cancer +is_a: MONDO:0021053 {source="MONDO:Redundant", source="NCIT:C3574"} ! carotid body paraganglioma +is_a: MONDO:0021069 {source="MONDO:Redundant", source="NCIT:C3574/inferred"} ! malignant endocrine neoplasm +is_a: MONDO:0021089 ! peripheral nervous system cancer +intersection_of: MONDO:0021053 ! carotid body paraganglioma +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch DOID:8731 +property_value: exactMatch http://identifiers.org/snomedct/447883002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153656 +property_value: exactMatch https://icd.codes/icd10cm/C75.4 +property_value: exactMatch NCIT:C3574 +property_value: excluded_subClassOf MONDO:0002095 {source="DOID:8731"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0004667 +name: sublingual gland cancer +def: "A rare malignant neoplasm that arises from the sublingual gland. The majority are carcinomas." [NCIT:C3527] +synonym: "cancer of sublingual gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sublingual gland" EXACT [MONDO:patterns/cancer, NCIT:C3527] +synonym: "malignant neoplasm of the sublingual gland" EXACT [NCIT:C3527] +synonym: "malignant sublingual gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3527] +synonym: "malignant sublingual gland tumor" EXACT [NCIT:C3527] +synonym: "malignant tumor of sublingual gland" EXACT [NCIT:C3527] +synonym: "malignant tumor of the sublingual gland" EXACT [DOID:8849, NCIT:C3527] +synonym: "sublingual gland cancer" EXACT [MONDO:patterns/location] +xref: DOID:8849 {source="MONDO:equivalentTo"} +xref: ICD9:142.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:8849"} +xref: NCIT:C3527 {source="MONDO:equivalentTo", source="DOID:8849"} +xref: SCTID:363381003 {source="MONDO:equivalentTo", source="DOID:8849"} +xref: UMLS:C0153361 {source="MONDO:equivalentTo", source="DOID:8849", source="NCIT:C3527"} +is_a: MONDO:0021242 {source="MONDO:Redundant", source="NCIT:C3527"} ! sublingual gland neoplasm +is_a: MONDO:0044743 ! major salivary gland cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001832 ! sublingual gland +property_value: exactMatch DOID:8849 +property_value: exactMatch http://identifiers.org/snomedct/363381003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153361 +property_value: exactMatch NCIT:C3527 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004669 +name: salivary gland cancer +def: "A primary or metastatic malignant neoplasm that affects the major or minor salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C3811] +synonym: "cancer of saliva-secreting gland" EXACT [MONDO:patterns/cancer] +synonym: "cancer of salivary gland" EXACT [NCIT:C3811] +synonym: "cancer of the salivary gland" EXACT [NCIT:C3811] +synonym: "malignant neoplasm of major salivary gland" NARROW [DOID:8850] +synonym: "malignant neoplasm of saliva-secreting gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of salivary gland" EXACT [NCIT:C3811] +synonym: "malignant neoplasm of salivary gland duct" EXACT [DOID:8850] +synonym: "malignant neoplasm of the salivary gland" EXACT [NCIT:C3811] +synonym: "malignant saliva-secreting gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant salivary gland neoplasm" EXACT [NCIT:C3811] +synonym: "malignant salivary gland tumor" EXACT [NCIT:C3811] +synonym: "malignant tumor of salivary gland" EXACT [NCIT:C3811] +synonym: "malignant tumor of the salivary gland" EXACT [NCIT:C3811] +synonym: "saliva-secreting gland cancer" EXACT [] +synonym: "salivary gland cancer" EXACT [NCIT:C3811] +xref: DOID:8850 {source="MONDO:equivalentTo"} +xref: ICD10CM:C08 {source="MONDO:equivalentTo", source="DOID:8850"} +xref: ICD9:142.8 {source="DOID:8850"} +xref: MESH:D012468 {source="MONDO:equivalentTo"} +xref: NCIT:C3811 {source="MONDO:equivalentTo"} +xref: SCTID:255072001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005515 {source="DOID:8850"} ! oral cavity cancer +is_a: MONDO:0021357 {source="MONDO:Redundant", source="NCIT:C3811"} ! tumor of salivary gland +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch DOID:8850 +property_value: exactMatch http://identifiers.org/mesh/D012468 +property_value: exactMatch http://identifiers.org/snomedct/255072001 +property_value: exactMatch https://icd.codes/icd10cm/C08 +property_value: exactMatch NCIT:C3811 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004670 +name: lupus erythematosus +def: "An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus." [NCIT:C27153] +synonym: "lupus" EXACT [DOID:8857, NCIT:C27153] +synonym: "lupus erythematosus" EXACT [NCIT:C27153] +xref: DOID:8857 {source="MONDO:equivalentTo"} +xref: ICD10CM:L93 {source="DOID:8857", source="MONDO:equivalentTo"} +xref: ICD9:695.4 {source="DOID:8857", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C27153 {source="DOID:8857", source="MONDO:equivalentTo"} +xref: SCTID:200936003 {source="DOID:8857", source="MONDO:equivalentTo"} +xref: UMLS:C0409974 {source="NCIT:C27153", source="DOID:8857", source="MONDO:equivalentTo"} +is_a: MONDO:0005554 {source="NCIT:C27153"} ! rheumatic disorder +is_a: MONDO:0007179 {source="DOID:8857", source="MONDO:Redundant", source="NCIT:C27153"} ! autoimmune disease +property_value: exactMatch DOID:8857 +property_value: exactMatch http://identifiers.org/snomedct/200936003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0409974 +property_value: exactMatch https://icd.codes/icd10cm/L93 +property_value: exactMatch NCIT:C27153 + +[Term] +id: MONDO:0004673 +name: lower lip cancer +def: "A malignant neoplasm involving the lower lip." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of lower lip" EXACT [MONDO:patterns/cancer] +synonym: "lower lip cancer" EXACT [MONDO:patterns/location] +synonym: "malignant lower lip neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of lower lip" EXACT [MONDO:patterns/cancer] +xref: DOID:8883 {source="MONDO:equivalentTo"} +xref: ICD9:140.1 {source="DOID:8883"} +xref: SCTID:363373004 {source="MONDO:equivalentTo", source="DOID:8883"} +xref: UMLS:C0432520 {source="MONDO:equivalentTo", source="DOID:8883"} +is_a: MONDO:0006834 {source="DOID:8883", source="MONDO:Redundant"} ! lip cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001835 ! lower lip +relationship: disease_has_location UBERON:0001835 ! lower lip +property_value: exactMatch DOID:8883 +property_value: exactMatch http://identifiers.org/snomedct/363373004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0432520 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004685 +name: Waldeyer's ring cancer +def: "A malignant neoplasm involving the tonsillar ring." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of tonsillar ring" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of tonsillar ring" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of Waldeyer's ring" EXACT [DOID:8937] +synonym: "malignant tonsillar ring neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of Waldeyer's ring" EXACT [DOID:8937] +synonym: "tonsillar ring cancer" EXACT [MONDO:patterns/location] +synonym: "Waldeyer ring cancer" EXACT [DOID:8937] +xref: DOID:8937 {source="MONDO:equivalentTo"} +xref: ICD10CM:C14.2 {source="MONDO:equivalentTo", source="DOID:8937"} +xref: ICD9:149.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:8937"} +xref: SCTID:187716008 {source="MONDO:equivalentTo", source="DOID:8937"} +xref: UMLS:C0153406 {source="MONDO:equivalentTo", source="DOID:8937"} +is_a: MONDO:0000621 ! immune system cancer +is_a: MONDO:0004608 {source="DOID:8937"} ! oropharynx cancer +is_a: MONDO:0044986 ! lymphoid system disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001735 ! tonsillar ring +relationship: disease_has_location UBERON:0001735 ! tonsillar ring +property_value: exactMatch DOID:8937 +property_value: exactMatch http://identifiers.org/snomedct/187716008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153406 +property_value: exactMatch https://icd.codes/icd10cm/C14.2 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004695 +name: liver lymphoma +def: "A rare lymphoma that arises from the liver and the bulk of the tumor is located in the liver. The most frequent types of lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma." [NCIT:C4949] +synonym: "hepatic lymphoma" EXACT [NCIT:C4949] +synonym: "liver lymphoma" EXACT [MONDO:patterns/location, NCIT:C4949] +synonym: "lymphoma of liver" EXACT [DOID:901, NCIT:C4949] +synonym: "lymphoma of the liver" EXACT [NCIT:C4949] +synonym: "primary hepatic lymphoma" EXACT [NCIT:C4949] +synonym: "primary liver lymphoma" EXACT [NCIT:C4949] +xref: DOID:901 {source="MONDO:equivalentTo"} +xref: NCIT:C4949 {source="DOID:901", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1112746 {source="NCIT:C4949", source="DOID:901", source="MONDO:equivalentTo"} +is_a: MONDO:0002691 {source="DOID:901", source="MONDO:Redundant", source="NCIT:C4949/inferred"} ! liver cancer +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C4949"} ! gastrointestinal lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002107 ! liver +property_value: exactMatch DOID:901 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1112746 +property_value: exactMatch NCIT:C4949 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004699 +name: gastrointestinal lymphoma +def: "A non-Hodgkin or Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site." [NCIT:P378] +synonym: "digestive system lymphoma" EXACT [MONDO:patterns/location, NCIT:C38162] +synonym: "gastrointestinal lymphoma" EXACT [NCIT:C38162] +synonym: "lymphoma of digestive system" EXACT [MONDO:design_pattern] +synonym: "primary digestive system lymphoma" EXACT [NCIT:C38162] +synonym: "primary gastrointestinal lymphoma" EXACT [NCIT:C38162] +xref: DOID:903 {source="MONDO:equivalentTo"} +xref: ICD9:202.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C38162 {source="DOID:903", source="MONDO:equivalentTo"} +xref: SCTID:449072004 {source="DOID:903", source="MONDO:equivalentTo"} +xref: UMLS:C0740372 {source="DOID:903", source="MONDO:equivalentTo", source="NCIT:C38162"} +is_a: MONDO:0002516 {source="DOID:903", source="NCIT:C38162"} ! digestive system cancer +is_a: MONDO:0005062 {source="MONDO:Redundant", source="NCIT:C38162/inferred"} ! lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001007 ! digestive system +property_value: exactMatch DOID:903 +property_value: exactMatch http://identifiers.org/snomedct/449072004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0740372 +property_value: exactMatch NCIT:C38162 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0004700 +name: parotid gland cancer +def: "A primary or metastatic malignant neoplasm involving the parotid gland. Representative examples include carcinoma, malignant mixed tumor, and non-Hodgkin lymphoma." [NCIT:C3525] +synonym: "cancer of parotid" EXACT [NCIT:C3525] +synonym: "cancer of parotid gland" EXACT [DOID:9036, MONDO:patterns/cancer, NCIT:C3525] +synonym: "cancer of the parotid" EXACT [NCIT:C3525] +synonym: "cancer of the parotid gland" EXACT [NCIT:C3525] +synonym: "malignant neoplasm of parotid" EXACT [NCIT:C3525] +synonym: "malignant neoplasm of parotid gland" EXACT [MONDO:patterns/cancer, NCIT:C3525] +synonym: "malignant neoplasm of the parotid" EXACT [DOID:9036, NCIT:C3525] +synonym: "malignant neoplasm of the parotid gland" EXACT [NCIT:C3525] +synonym: "malignant parotid gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3525] +synonym: "malignant parotid gland tumor" EXACT [NCIT:C3525] +synonym: "malignant parotid neoplasm" EXACT [NCIT:C3525] +synonym: "malignant parotid tumor" EXACT [NCIT:C3525] +synonym: "malignant tumor of parotid" EXACT [NCIT:C3525] +synonym: "malignant tumor of parotid gland" EXACT [NCIT:C3525] +synonym: "malignant tumor of the parotid" EXACT [NCIT:C3525] +synonym: "malignant tumor of the parotid gland" EXACT [NCIT:C3525] +synonym: "parotid cancer" EXACT [DOID:9036] +synonym: "parotid gland cancer" EXACT [MONDO:patterns/location, NCIT:C3525] +xref: DOID:9036 {source="MONDO:equivalentTo"} +xref: ICD9:142.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9036"} +xref: MESH:D010307 {source="MONDO:equivalentTo", source="DOID:9036"} +xref: NCIT:C3525 {source="MONDO:equivalentTo", source="DOID:9036"} +xref: SCTID:363379000 {source="MONDO:equivalentTo", source="DOID:9036"} +xref: UMLS:C0747273 {source="MONDO:equivalentTo", source="DOID:9036", source="NCIT:C3525"} +is_a: MONDO:0021243 {source="MONDO:Redundant", source="NCIT:C3525"} ! parotid gland neoplasm +is_a: MONDO:0044743 ! major salivary gland cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch DOID:9036 +property_value: exactMatch http://identifiers.org/mesh/D010307 +property_value: exactMatch http://identifiers.org/snomedct/363379000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0747273 +property_value: exactMatch NCIT:C3525 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004709 +name: occipital lobe neoplasm +def: "A neoplasm involving a occipital lobe." [MONDO:patterns/neoplasm] +synonym: "malignant neoplasm of occipital lobe" EXACT [DOID:910] +synonym: "neoplasm of occipital lobe" EXACT [MONDO:patterns/neoplasm, NCIT:C5574] +synonym: "neoplasm of the occipital lobe" EXACT [NCIT:C5574] +synonym: "occipital lobe neoplasm" EXACT [NCIT:C5574] +synonym: "occipital lobe neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "occipital lobe tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5574] +synonym: "tumor of occipital lobe" EXACT [DOID:910, MONDO:patterns/neoplasm, NCIT:C5574] +synonym: "tumor of the occipital lobe" EXACT [NCIT:C5574] +xref: DOID:910 {source="MONDO:equivalentTo"} +xref: ICD10CM:C71.4 {source="DOID:910", source="MONDO:equivalentTo"} +xref: ICD9:191.4 {source="DOID:910"} +xref: NCIT:C5574 {source="DOID:910", source="MONDO:equivalentTo"} +xref: SCTID:126957005 {source="DOID:910", source="MONDO:equivalentTo"} +xref: UMLS:C0153638 {source="DOID:910", source="MONDO:equivalentTo"} +xref: UMLS:C1263889 {source="DOID:910", source="NCIT:C5574", source="MONDO:equivalentTo"} +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C5574"} ! neoplasm of cerebral hemisphere +is_a: MONDO:0044996 ! cerebral cortex disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002021 ! occipital lobe +relationship: disease_has_location UBERON:0002021 ! occipital lobe +property_value: exactMatch DOID:910 +property_value: exactMatch http://identifiers.org/snomedct/126957005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153638 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263889 +property_value: exactMatch https://icd.codes/icd10cm/C71.4 +property_value: exactMatch NCIT:C5574 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004712 +name: herpes simplex dermatitis +def: "Localized rash characterized by grouped vesicles or pustules on an erythematous base that is caused by herpes simplex virus infection." [NCIT:C35620] +synonym: "eczema herpeticum" RELATED [DOID:9123] +synonym: "eczema herpeticum (disorder) [ambiguous]" EXACT [DOID:9123] +synonym: "Herpes simplex dermatitis" EXACT [NCIT:C35620] +synonym: "herpes simplex dermatitis" EXACT [DOID:9123] +synonym: "Herpes simplex dermatitis of eyelid" NARROW [DOID:9123] +synonym: "Herpes simplex eyelid dermatitis" NARROW [DOID:9123] +synonym: "Herpes simplex virus dermatitis" EXACT [DOID:9123] +synonym: "herpes simplex virus eyelid dermatitis" NARROW [DOID:9123] +synonym: "Simplexvirus caused dermatitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Simplexvirus dermatitis" EXACT [] +xref: DOID:9123 {source="MONDO:equivalentTo"} +xref: ICD10CM:B00.0 {source="MONDO:equivalentTo", source="DOID:9123"} +xref: ICD9:054.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9123"} +xref: ICD9:054.41 {source="DOID:9123"} +xref: MESH:D007617 {source="MONDO:equivalentTo", source="DOID:9123"} +xref: NCIT:C35620 {source="MONDO:equivalentTo", source="DOID:9123"} +xref: SCTID:186535001 {source="MONDO:equivalentTo", source="DOID:9123"} +xref: UMLS:C0854331 {source="MONDO:equivalentTo", source="NCIT:C35620", source="DOID:9123"} +is_a: MONDO:0004609 {source="DOID:9123", source="ICD10CM:B00.0", source="MESH:D007617", source="MONDO:Entailed", source="MONDO:Redundant"} ! herpes simplex infectious disease +is_a: MONDO:0021201 {source="MONDO:Redundant", source="NCIT:C35620"} ! skin infection +intersection_of: MONDO:0002406 ! dermatitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +property_value: exactMatch DOID:9123 +property_value: exactMatch http://identifiers.org/mesh/D007617 +property_value: exactMatch http://identifiers.org/snomedct/186535001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854331 +property_value: exactMatch https://icd.codes/icd10cm/B00.0 +property_value: exactMatch NCIT:C35620 + +[Term] +id: MONDO:0004713 +name: lower gum cancer +def: "A cancer involving a gingiva of lower jaw." [MONDO:patterns/cancer] +synonym: "cancer of gingiva of lower jaw" EXACT [MONDO:patterns/cancer] +synonym: "gingiva of lower jaw cancer" EXACT [MONDO:patterns/location] +synonym: "malignant gingiva of lower jaw neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of gingiva of lower jaw" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of lower gingiva" EXACT [DOID:9125] +synonym: "malignant tumour of lower gum" EXACT [DOID:9125] +xref: DOID:9125 {source="MONDO:equivalentTo"} +xref: ICD9:143.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9125"} +xref: SCTID:363384006 {source="MONDO:equivalentTo", source="DOID:9125"} +xref: UMLS:C0432581 {source="MONDO:equivalentTo", source="DOID:9125"} +is_a: MONDO:0005507 {source="DOID:9125", source="MONDO:Redundant"} ! gingival cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0011602 ! gingiva of lower jaw +relationship: disease_has_location UBERON:0011602 ! gingiva of lower jaw +property_value: exactMatch DOID:9125 +property_value: exactMatch http://identifiers.org/snomedct/363384006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0432581 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004719 +name: hard palate cancer +def: "A malignant neoplasm involving the hard palate." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of hard palate" EXACT [MONDO:patterns/cancer] +synonym: "hard palate" EXACT [DOID:9149, NCIT:C12230] +synonym: "hard palate cancer" EXACT [MONDO:patterns/location] +synonym: "malignant hard palate neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant hard palate tumor" EXACT [NCIT:C3528] +synonym: "malignant neoplasm of hard palate" EXACT [DOID:9149, MONDO:patterns/cancer, MTH:U001235] +synonym: "malignant neoplasm of the hard palate" EXACT [NCIT:C3528] +synonym: "malignant tumor of hard palate" EXACT [NCIT:C3528] +synonym: "malignant tumor of the hard palate" EXACT [DOID:9149, NCIT:C3528] +synonym: "malignant tumour of hard palate" EXACT [DOID:9149] +xref: DOID:9149 {source="MONDO:equivalentTo"} +xref: ICD10CM:C05.0 {source="DOID:9149", source="MONDO:equivalentTo"} +xref: ICD9:145.2 {source="DOID:9149", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3528 {source="DOID:9149", source="MONDO:equivalentTo"} +xref: SCTID:363387004 {source="DOID:9149", source="MONDO:equivalentTo"} +xref: UMLS:C0153375 {source="DOID:9149", source="NCIT:C3528", source="MONDO:equivalentTo"} +is_a: MONDO:0005286 ! palatal neoplasm +is_a: MONDO:0005515 {source="DOID:9149", source="MONDO:Redundant", source="NCIT:C3528/inferred"} ! oral cavity cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003216 ! hard palate +relationship: disease_has_location UBERON:0003216 ! hard palate +property_value: exactMatch DOID:9149 +property_value: exactMatch http://identifiers.org/snomedct/363387004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153375 +property_value: exactMatch https://icd.codes/icd10cm/C05.0 +property_value: exactMatch NCIT:C3528 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004721 +name: liver neoplasm +def: "A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma." [NCIT:P378] +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: obsoletion_candidate +synonym: "epithelial hepatic and intrahepatic bile duct neoplasm" EXACT [DOID:916] +synonym: "liver and intrahepatic bile duct epithelial neoplasm" EXACT [NCIT:C7106] +synonym: "liver neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "liver tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of liver" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of liver" EXACT [MONDO:patterns/neoplasm] +xref: DOID:916 {source="MONDO:equivalentTo"} +xref: EFO:1001513 {source="MONDO:equivalentTo"} +xref: NCIT:C7103 {source="DOID:916", source="MONDO:directSiblingOf"} +xref: NCIT:C7106 {source="MONDO:equivalentTo", source="DOID:916"} +xref: ONCOTREE:LIVER {source="MONDO:equivalentTo"} +xref: SCTID:126851005 {source="MONDO:equivalentTo"} +xref: UMLS:C0023903 {source="MONDO:equivalentTo"} +xref: UMLS:C1333976 {source="DOID:916", source="MONDO:directSiblingOf"} +is_a: MONDO:0002082 ! endocrine gland neoplasm +is_a: MONDO:0002514 {source="DOID:916", source="MONDO:Redundant", source="NCIT:C7106/inferred"} ! hepatobiliary neoplasm +is_a: MONDO:0005154 ! liver disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002107 ! liver +property_value: exactMatch DOID:916 +property_value: exactMatch http://identifiers.org/snomedct/126851005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023903 +property_value: exactMatch NCIT:C7106 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0004724 +name: submandibular gland cancer +def: "A malignant neoplasm involving the submandibular gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of submandibular gland" EXACT [MONDO:patterns/cancer] +synonym: "carcinoma of submandibular gland" EXACT [NCIT:C8396] +synonym: "carcinoma of the submandibular gland" EXACT [NCIT:C8396] +synonym: "malignant neoplasm of submandibular gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of submaxillary gland" EXACT [DOID:9173] +synonym: "malignant submandibular gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of submandibular gland" EXACT [DOID:9173] +synonym: "malignant tumor of the submandibular gland" EXACT [DOID:9173, NCIT:C3526] +synonym: "submandibular gland cancer" EXACT [MONDO:patterns/location, NCIT:C8396] +synonym: "submandibular gland carcinoma" EXACT [NCIT:C8396] +xref: DOID:9173 {source="MONDO:equivalentTo"} +xref: ICD9:142.1 {source="DOID:9173", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C8396 {source="MONDO:equivalentTo"} +xref: SCTID:363380002 {source="DOID:9173", source="MONDO:equivalentTo"} +xref: UMLS:C0153360 {source="DOID:9173", source="MONDO:equivalentTo"} +is_a: MONDO:0006284 {source="NCIT:C8396"} ! major salivary gland carcinoma +is_a: MONDO:0021244 {source="MONDO:Redundant", source="NCIT:C8396/inferred"} ! submandibular gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001736 ! submandibular gland +property_value: exactMatch DOID:9173 +property_value: exactMatch http://identifiers.org/snomedct/363380002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153360 +property_value: exactMatch NCIT:C8396 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004727 +name: vestibule of mouth cancer +def: "A cancer that involves the oral opening." [MONDO:patterns/location] +synonym: "cancer of oral opening" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of oral opening" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of vestibule of mouth" EXACT [DOID:9188] +synonym: "malignant oral opening neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of vestibule of mouth" EXACT [DOID:9188, MTH:U001025] +synonym: "oral opening cancer" EXACT [MONDO:patterns/location] +xref: DOID:9188 {source="MONDO:equivalentTo"} +xref: ICD10CM:C06.1 {source="MONDO:equivalentTo", source="DOID:9188"} +xref: ICD9:145.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9188"} +xref: SCTID:187658004 {source="MONDO:equivalentTo", source="DOID:9188"} +xref: UMLS:C0153374 {source="MONDO:equivalentTo", source="DOID:9188"} +is_a: MONDO:0005515 {source="DOID:9188"} ! oral cavity cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000166 ! oral opening +relationship: disease_has_location UBERON:0000166 ! oral opening +property_value: exactMatch DOID:9188 +property_value: exactMatch http://identifiers.org/snomedct/187658004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153374 +property_value: exactMatch https://icd.codes/icd10cm/C06.1 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004736 +name: inherited amino acid metabolic disorder +def: "An inherited disorder that affects the metabolism of the amino acids. Representative examples include alkaptonuria, homocystinuria, tyrosinemia, and phenylketonuria." [NCIT:P378] +synonym: "amino acid metabolic disorder" RELATED [DOID:9252] +synonym: "amino acid metabolism, inborn errors" RELATED [GARD:0006770] +synonym: "inborn amino acid metabolism disorder" RELATED [GARD:0006770] +synonym: "inborn cellular amino acid metabolic process disorder" EXACT [] +synonym: "inborn error of amino acid metabolism" EXACT [] +synonym: "inborn error of cellular amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn errors of amino acid metabolism" EXACT [DOID:9252] +synonym: "rare inborn error of cellular amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:9252 {source="MONDO:equivalentTo"} +xref: GARD:0006770 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD9:270 {source="DOID:9252"} +xref: ICD9:270.9 {source="DOID:9252"} +xref: MESH:D000592 {source="MONDO:equivalentTo", source="DOID:9252"} +xref: SCTID:42930003 {source="MONDO:equivalentTo", source="DOID:9252"} +is_a: MONDO:0000688 ! inherited organic acidemia +is_a: MONDO:0037871 ! amino acid metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006520 ! cellular amino acid metabolic process +property_value: exactMatch DOID:9252 +property_value: exactMatch http://identifiers.org/mesh/D000592 +property_value: exactMatch http://identifiers.org/snomedct/42930003 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0004737 +name: homocystinuria +def: "An autosomal recessive inherited metabolic disorder caused by mutations in the CBS, MTHFR, MTR, and MTRR genes. It is characterized by abnormalities in the methionine metabolism and is associated with deficiency of cystathionine synthase. It results in the accumulation of homocysteine in the serum. It may affect the cardiovascular, musculoskeletal and the central nervous systems." [NCIT:P378] +synonym: "CBS deficiency" NARROW [DOID:9263] +synonym: "cystathionine beta synthase deficiency" NARROW [DOID:9263] +synonym: "cystathionine synthase deficiency" NARROW [DOID:9263] +synonym: "homocystinuria" EXACT [MONDO:ambiguous] +synonym: "homocystinuria (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:9263 {source="MONDO:equivalentTo"} +xref: GARD:0010770 {source="MONDO:equivalentTo"} +xref: HP:0002156 {source="MONDO:otherHierarchy"} +xref: ICD10CM:E72.11 {source="MONDO:equivalentTo", source="DOID:9263"} +xref: NCIT:C84765 {source="MONDO:equivalentTo", source="DOID:9263"} +xref: SCTID:11282001 {source="MONDO:equivalentTo", source="DOID:9263"} +xref: UMLS:C0019880 {source="NCIT:C84765", source="MONDO:equivalentTo", source="DOID:9263"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +is_a: MONDO:0019222 ! inborn disorder of methionine cycle and sulfur amino acid metabolism +intersection_of: MONDO:0004736 ! inherited amino acid metabolic disorder +intersection_of: disease_has_basis_in_disruption_of GO:0050667 ! homocysteine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0050667 ! homocysteine metabolic process +property_value: exactMatch DOID:9263 +property_value: exactMatch http://identifiers.org/snomedct/11282001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019880 +property_value: exactMatch https://icd.codes/icd10cm/E72.11 +property_value: exactMatch NCIT:C84765 +property_value: IAO:0000589 "homocystinuria (disease)" xsd:string + +[Term] +id: MONDO:0004738 +name: histidine metabolism disease +def: "A disease that has its basis in the disruption of histidine metabolic process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of histidine metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of histidine metabolism" EXACT [] +synonym: "disturbance of histidine metabolism" EXACT [] +synonym: "histidine metabolic process disease" EXACT [MONDO:design_pattern] +xref: SCTID:44176004 {source="MONDO:equivalentTo"} +xref: UMLS:C0268512 {source="MONDO:equivalentTo"} +is_a: MONDO:0037871 ! amino acid metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006547 ! histidine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006547 ! histidine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/44176004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268512 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0004746 +name: myopathy of extraocular muscle +def: "A myopathy that involves the extra-ocular muscle." [MONDO:patterns/location] +synonym: "extra-ocular muscle myopathy" EXACT [MONDO:patterns/location] +synonym: "myopathy of extra-ocular muscle" EXACT [MONDO:design_pattern] +synonym: "myopathy of extraocular muscles" EXACT [DOID:929] +xref: DOID:929 {source="MONDO:equivalentTo"} +xref: ICD9:376.82 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:929"} +xref: SCTID:57130002 {source="MONDO:equivalentTo", source="DOID:929"} +xref: UMLS:C0155286 {source="MONDO:equivalentTo", source="DOID:929"} +is_a: MONDO:0000462 ! eye adnexa disorder +is_a: MONDO:0005336 {source="DOID:929", source="MONDO:Redundant"} ! myopathy +is_a: MONDO:0020120 {source="MONDO:Redundant"} ! skeletal muscle disorder +is_a: MONDO:0024458 ! disorder of visual system +intersection_of: MONDO:0005336 ! myopathy +intersection_of: disease_has_location UBERON:0001601 ! extra-ocular muscle +relationship: disease_has_location UBERON:0001601 ! extra-ocular muscle +property_value: exactMatch DOID:929 +property_value: exactMatch http://identifiers.org/snomedct/57130002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155286 + +[Term] +id: MONDO:0004748 +name: lip disorder +def: "A disease involving the lip." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of lip" EXACT [MONDO:patterns/location_top] +synonym: "disease of lips" EXACT [DOID:9297, ICD9CM:528.5] +synonym: "disease or disorder of lip" EXACT [] +synonym: "disorder of lip" EXACT [MONDO:patterns/location_top] +synonym: "lip disease" EXACT [MONDO:patterns/location] +synonym: "lip disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lip disorder" EXACT [NCIT:C26818] +xref: DOID:9297 {source="MONDO:equivalentTo"} +xref: ICD9:528.5 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9297"} +xref: MESH:D008047 {source="MONDO:equivalentTo", source="DOID:9297"} +xref: NCIT:C26818 {source="MONDO:equivalentTo", source="DOID:9297"} +xref: SCTID:90678009 {source="MONDO:equivalentTo", source="DOID:9297"} +xref: UMLS:C0023760 {source="NCIT:C26818", source="MONDO:equivalentTo", source="DOID:9297"} +is_a: MONDO:0002051 ! integumentary system disorder +is_a: MONDO:0006858 {source="DOID:9297", source="MESH:D008047", source="MONDO:Redundant", source="NCIT:C26818"} ! mouth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001833 ! lip +relationship: disease_has_location UBERON:0001833 ! lip +property_value: exactMatch DOID:9297 +property_value: exactMatch http://identifiers.org/mesh/D008047 +property_value: exactMatch http://identifiers.org/snomedct/90678009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023760 +property_value: exactMatch NCIT:C26818 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004749 +name: myocardium cancer +def: "A malignant neoplasm involving the myocardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of myocardium" EXACT [MONDO:patterns/cancer] +synonym: "malignant myocardial neoplasm" EXACT [NCIT:C4569] +synonym: "malignant myocardial tumor" EXACT [DOID:9299, NCIT:C4569] +synonym: "malignant myocardium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of myocardium" EXACT [DOID:9299, MONDO:patterns/cancer, NCIT:C4569] +synonym: "malignant neoplasm of the myocardium" EXACT [NCIT:C4569] +synonym: "malignant tumor of myocardium" EXACT [NCIT:C4569] +synonym: "malignant tumor of the myocardium" EXACT [NCIT:C4569] +synonym: "myocardium cancer" EXACT [MONDO:patterns/location] +synonym: "tumor of myocardium" BROAD [DOID:9299, NCIT:C5349] +xref: DOID:9299 {source="MONDO:equivalentTo"} +xref: NCIT:C4569 {source="MONDO:equivalentTo", source="DOID:9299"} +xref: UMLS:C0346611 {source="MONDO:equivalentTo", source="DOID:9299", source="NCIT:C4569"} +is_a: MONDO:0000637 ! musculoskeletal system cancer +is_a: MONDO:0001340 {source="DOID:9299", source="MONDO:Redundant", source="NCIT:C4569"} ! heart cancer +is_a: MONDO:0021380 {source="MONDO:Redundant", source="NCIT:C4569"} ! neoplasm of myocardium +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002349 ! myocardium +property_value: exactMatch DOID:9299 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346611 +property_value: exactMatch NCIT:C4569 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0004756 +name: nasal cavity neoplasm +def: "A benign or malignant neoplasm that affects the nasal cavity. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:C4413] +synonym: "nasal cavity neoplasm" EXACT [NCIT:C4413] +synonym: "nasal cavity neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nasal cavity tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4413] +synonym: "neoplasm of nasal cavity" EXACT [MONDO:patterns/neoplasm, NCIT:C4413] +synonym: "neoplasm of the nasal cavity" EXACT [NCIT:C4413] +synonym: "tumor of nasal cavity" EXACT [MONDO:patterns/neoplasm, NCIT:C4413] +synonym: "tumor of the nasal cavity" EXACT [DOID:9310, NCIT:C4413] +xref: DOID:9310 {source="MONDO:equivalentTo"} +xref: NCIT:C4413 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:9310"} +xref: SCTID:126670003 {source="MONDO:equivalentTo", source="DOID:9310"} +xref: UMLS:C0345630 {source="MONDO:equivalentTo", source="NCIT:C4413", source="DOID:9310"} +is_a: MONDO:0002232 {source="DOID:9310", source="MONDO:Redundant", source="NCIT:C4413"} ! nasal cavity disorder +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C4413/inferred"} ! head and neck neoplasm +is_a: MONDO:0020641 ! respiratory tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:9310 +property_value: exactMatch http://identifiers.org/snomedct/126670003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345630 +property_value: exactMatch NCIT:C4413 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004757 +name: chronic ethmoidal sinusitis +def: "Inflammation of the ethmoid sinus that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or a deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties." [NCIT:C34472] +synonym: "chronic ethmoid sinusitis" EXACT [DOID:9312] +synonym: "chronic ethmoidal sinusitis" EXACT [DOID:9312, NCIT:C34472] +synonym: "chronic ethmoiditis" RELATED [DOID:9312] +synonym: "ethmoid sinusitis, chronic" EXACT [MONDO:patterns/chronic] +synonym: "ethmoidal sinusitis - chronic" EXACT [DOID:9312] +xref: DOID:9312 {source="MONDO:equivalentTo"} +xref: ICD10CM:J32.2 {source="MONDO:equivalentTo", source="DOID:9312"} +xref: ICD9:473.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9312"} +xref: NCIT:C34472 {source="MONDO:equivalentTo", source="DOID:9312"} +xref: SCTID:73237007 {source="MONDO:equivalentTo", source="DOID:9312"} +xref: UMLS:C0008681 {source="NCIT:C34472", source="MONDO:equivalentTo", source="DOID:9312"} +is_a: MONDO:0005756 {source="DOID:9312", source="MONDO:Redundant", source="NCIT:C34472"} ! ethmoid sinusitis +is_a: MONDO:0006031 {source="MONDO:Redundant", source="NCIT:C34472"} ! chronic rhinosinusitis +intersection_of: MONDO:0005756 ! ethmoid sinusitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:9312 +property_value: exactMatch http://identifiers.org/snomedct/73237007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008681 +property_value: exactMatch https://icd.codes/icd10cm/J32.2 +property_value: exactMatch NCIT:C34472 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0004767 +name: vesiculitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the seminal vesicle." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "gland, seminal vesicle" EXACT [NCIT:C12787] +synonym: "inflammation of seminal vesicle" EXACT [] +synonym: "seminal Sacs" EXACT [NCIT:C12787] +synonym: "seminal vesicle" EXACT [NCIT:C12787] +synonym: "seminal vesicle inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "seminal vesicles" EXACT [NCIT:C12787] +synonym: "seminal vesiculitis" EXACT [DOID:9365, ICD9CM:608.0] +xref: DOID:9365 {source="MONDO:equivalentTo"} +xref: ICD9:608.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9365"} +xref: NCIT:C12787 {source="MONDO:equivalentTo"} +xref: SCTID:27001009 {source="MONDO:equivalentTo", source="DOID:9365"} +xref: UMLS:C0042588 {source="MONDO:equivalentTo", source="DOID:9365"} +is_a: MONDO:0006882 ! orchitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000998 ! seminal vesicle +relationship: disease_has_inflammation_site UBERON:0000998 ! seminal vesicle +property_value: exactMatch DOID:9365 +property_value: exactMatch http://identifiers.org/snomedct/27001009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042588 +property_value: exactMatch NCIT:C12787 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004768 +name: keratoconjunctivitis +def: "Inflammation of both the cornea and the conjunctiva." [NCIT:P378] +xref: DOID:9368 {source="MONDO:equivalentTo"} +xref: HP:0001096 {source="MONDO:otherHierarchy"} +xref: ICD10CM:H16.2 {source="MONDO:equivalentTo", source="DOID:9368"} +xref: ICD9:370.40 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9368"} +xref: ICD9:370.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:370.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007637 {source="MONDO:equivalentTo", source="DOID:9368"} +xref: NCIT:C34744 {source="MONDO:equivalentTo", source="DOID:9368"} +xref: SCTID:88151007 {source="MONDO:equivalentTo", source="DOID:9368"} +xref: UMLS:C0022573 {source="MONDO:equivalentTo", source="NCIT:C34744", source="DOID:9368"} +is_a: MONDO:0003085 {source="ICD10CM:H16.2", source="MESH:D007637", source="MONDO:Redundant"} ! keratitis +is_a: MONDO:0003799 {source="MESH:D007637", source="MONDO:Redundant"} ! conjunctivitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000964 ! cornea +intersection_of: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:9368 +property_value: exactMatch http://identifiers.org/mesh/D007637 +property_value: exactMatch http://identifiers.org/snomedct/88151007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022573 +property_value: exactMatch https://icd.codes/icd10cm/H16.2 +property_value: exactMatch NCIT:C34744 + +[Term] +id: MONDO:0004773 +name: iridocyclitis +def: "An inflammation of the iris and the ciliary body" [MONDO:cjm, Wikipedia:Uveitis#Classification] +synonym: "iridocyclitis" EXACT [MONDO:ambiguous] +synonym: "iridocyclitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "primary iridocyclitis" NARROW [DOID:9383] +xref: DOID:9383 {source="MONDO:equivalentTo"} +xref: HP:0001094 {source="MONDO:otherHierarchy"} +xref: ICD9:364.01 {source="DOID:9383"} +xref: ICD9:364.2 {source="DOID:9383"} +xref: ICD9:364.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C34736 {source="MONDO:equivalentTo"} +xref: SCTID:77971008 {source="MONDO:equivalentTo"} +xref: UMLS:C0022073 {source="MONDO:equivalentTo", source="NCIT:C34736"} +is_a: MONDO:0002970 ! ciliary body disorder +is_a: MONDO:0006651 {source="DOID:9383", source="NCIT:C34736"} ! anterior uveitis +is_a: MONDO:0006814 {source="MONDO:Redundant"} ! iritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001769 ! iris +intersection_of: disease_has_inflammation_site UBERON:0001775 ! ciliary body +relationship: disease_has_inflammation_site UBERON:0001775 ! ciliary body +property_value: exactMatch DOID:9383 +property_value: exactMatch http://identifiers.org/snomedct/77971008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022073 +property_value: exactMatch NCIT:C34736 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: IAO:0000589 "iridocyclitis (disease)" xsd:string + +[Term] +id: MONDO:0004777 +name: acute laryngitis +def: "An acute inflammatory process affecting the larynx. It is caused by bacteria, viruses, or vocal strain. Signs and symptoms include sore throat, cough, swallowing difficulties, and hoarseness." [NCIT:P378] +synonym: "laryngitis" BROAD [NCIT:C26688] +synonym: "laryngitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:9396 {source="MONDO:equivalentTo"} +xref: ICD10CM:J04.0 {source="MONDO:equivalentTo", source="DOID:9396"} +xref: ICD9:464.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9396"} +xref: ICD9:464.00 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:464.01 {source="DOID:9396"} +xref: NCIT:C26688 {source="MONDO:equivalentTo", source="DOID:9396"} +xref: SCTID:6655004 {source="MONDO:equivalentTo", source="DOID:9396"} +xref: UMLS:C0001327 {source="MONDO:equivalentTo", source="NCIT:C26688", source="DOID:9396"} +is_a: MONDO:0002647 {source="DOID:9396", source="MONDO:Redundant", source="NCIT:C26688"} ! laryngitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0002647 ! laryngitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:9396 +property_value: exactMatch http://identifiers.org/snomedct/6655004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001327 +property_value: exactMatch https://icd.codes/icd10cm/J04.0 +property_value: exactMatch NCIT:C26688 + +[Term] +id: MONDO:0004778 +name: epididymo-orchitis +def: "A disorder involving inflammation of the epididymis and testes." [https://www.merckmanuals.com/home/men-s-health-issues/penile-and-testicular-disorders/epididymitis-and-epididymo-orchitis, MONDO:cjm] +xref: DOID:9401 {source="MONDO:equivalentTo"} +xref: ICD10CM:N45.3 {source="MONDO:equivalentTo", source="DOID:9401"} +xref: ICD9:604 {source="DOID:9401"} +xref: ICD9:604.90 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9401"} +xref: SCTID:197983000 {source="MONDO:equivalentTo", source="DOID:9401"} +xref: UMLS:C0149881 {source="MONDO:equivalentTo", source="DOID:9401"} +is_a: MONDO:0004779 {source="DOID:9401", source="MONDO:Redundant"} ! epididymitis +is_a: MONDO:0006882 {source="MONDO:Redundant"} ! orchitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0000473 ! testis +intersection_of: disease_has_inflammation_site UBERON:0001301 ! epididymis +property_value: exactMatch DOID:9401 +property_value: exactMatch http://identifiers.org/snomedct/197983000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149881 +property_value: exactMatch https://icd.codes/icd10cm/N45.3 + +[Term] +id: MONDO:0004779 +name: epididymitis +def: "Inflammation of the epididymis. Its clinical features include enlarged epididymis, a swollen scrotum; pain; pyuria; and fever. It is usually related to infections in the urinary tract, which likely spread to the epididymis through either the vas deferens or the lymphatics of the spermatic cord." [MESH:D004823] +synonym: "epididymal" EXACT [NCIT:C12328] +synonym: "epididymis" EXACT [NCIT:C12328] +synonym: "epididymitis" EXACT [MONDO:ambiguous] +synonym: "epididymitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:9402 {source="MONDO:equivalentTo"} +xref: HP:0000031 {source="MONDO:otherHierarchy"} +xref: ICD10CM:N45.1 {source="DOID:9402", source="MONDO:equivalentTo"} +xref: MESH:D004823 {source="DOID:9402", source="MONDO:equivalentTo"} +xref: NCIT:C12328 {source="MONDO:equivalentTo"} +xref: SCTID:31070006 {source="DOID:9402", source="MONDO:equivalentTo"} +xref: UMLS:C0014534 {source="DOID:9402", source="MONDO:equivalentTo"} +is_a: MONDO:0003150 {source="DOID:9402", source="ICD10CM:N45.1/inferred", source="MESH:D004823", source="MONDO:Redundant"} ! male reproductive system disorder +is_a: MONDO:0005550 ! infectious disease +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001301 ! epididymis +relationship: disease_has_inflammation_site UBERON:0001301 ! epididymis +property_value: exactMatch DOID:9402 +property_value: exactMatch http://identifiers.org/mesh/D004823 +property_value: exactMatch http://identifiers.org/snomedct/31070006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014534 +property_value: exactMatch https://icd.codes/icd10cm/N45.1 +property_value: exactMatch NCIT:C12328 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "epididymitis (disease)" xsd:string + +[Term] +id: MONDO:0004784 +name: allergic asthma +def: "A asthma with a basis in a pathological type I hypersensitivity reaction." [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic form of asthma" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "atopic asthma" RELATED [DOID:9415] +synonym: "extrinsic asthma with acute exacerbation" EXACT [DOID:9415] +synonym: "extrinsic asthma with status asthmaticus" EXACT [DOID:9415] +xref: DOID:9415 {source="MONDO:equivalentTo"} +xref: ICD9:493.0 {source="DOID:9415"} +xref: SCTID:389145006 {source="DOID:9415", source="MONDO:equivalentTo"} +xref: UMLS:C0155877 {source="DOID:9415", source="MONDO:equivalentTo"} +is_a: MONDO:0000771 ! allergic respiratory disease +is_a: MONDO:0004979 {source="DOID:9415", source="MONDO:Entailed", source="MONDO:Redundant"} ! asthma +intersection_of: MONDO:0004979 ! asthma +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +property_value: exactMatch DOID:9415 +property_value: exactMatch http://identifiers.org/snomedct/389145006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155877 + +[Term] +id: MONDO:0004785 +name: blepharitis +def: "Inflammation of the eyelids near the eyelashes." [NCIT:P378] +synonym: "eyelid inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of eyelid" EXACT [] +xref: DOID:9423 {source="MONDO:equivalentTo"} +xref: ICD10CM:H01.0 {source="MONDO:equivalentTo", source="DOID:9423"} +xref: ICD9:373.0 {source="DOID:9423"} +xref: ICD9:373.00 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9423"} +xref: ICD9:373.4 {source="DOID:9423"} +xref: ICD9:373.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:373.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9423"} +xref: MESH:D001762 {source="MONDO:equivalentTo", source="DOID:9423"} +xref: NCIT:C112183 {source="MONDO:equivalentTo", source="DOID:9423"} +xref: SCTID:41446000 {source="MONDO:equivalentTo", source="DOID:9423"} +xref: UMLS:C0005741 {source="NCIT:C112183", source="MONDO:equivalentTo", source="DOID:9423"} +is_a: MONDO:0003382 {source="DOID:9423", source="MESH:D001762", source="MONDO:Redundant"} ! eyelid disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001711 ! eyelid +relationship: disease_has_inflammation_site UBERON:0001711 ! eyelid +property_value: exactMatch DOID:9423 +property_value: exactMatch http://identifiers.org/mesh/D001762 +property_value: exactMatch http://identifiers.org/snomedct/41446000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005741 +property_value: exactMatch https://icd.codes/icd10cm/H01.0 +property_value: exactMatch NCIT:C112183 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004786 +name: chronic cholangitis +def: "Cholangitis that is persistent and long-standing." [NCIT:P378] +synonym: "cholangitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:9439 {source="MONDO:equivalentTo"} +xref: NCIT:C35335 {source="DOID:9439", source="MONDO:equivalentTo"} +xref: SCTID:71912000 {source="DOID:9439", source="MONDO:equivalentTo"} +xref: UMLS:C0267918 {source="DOID:9439", source="MONDO:equivalentTo", source="NCIT:C35335"} +is_a: MONDO:0004789 {source="DOID:9439", source="MONDO:Redundant", source="NCIT:C35335"} ! cholangitis +intersection_of: MONDO:0004789 ! cholangitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:9439 +property_value: exactMatch http://identifiers.org/snomedct/71912000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267918 +property_value: exactMatch NCIT:C35335 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0004789 +name: cholangitis +def: "An acute or chronic inflammatory process affecting the biliary tract." [NCIT:C26718] +synonym: "biliary tract infection" EXACT [NCIT:C26718] +synonym: "biliary tree inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "cholangitis" EXACT [NCIT:C26718] +synonym: "inflammation of biliary tree" EXACT [] +xref: DOID:9446 {source="MONDO:equivalentTo"} +xref: ICD10CM:K83.0 {source="DOID:9446", source="MONDO:equivalentTo"} +xref: ICD9:576.1 {source="DOID:9446", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D002761 {source="DOID:9446", source="MONDO:equivalentTo"} +xref: NCIT:C26718 {source="DOID:9446", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:82403002 {source="DOID:9446", source="MONDO:equivalentTo"} +xref: UMLS:C0008311 {source="DOID:9446", source="NCIT:C26718", source="MONDO:equivalentTo"} +is_a: MONDO:0006322 {source="NCIT:C26718"} ! non-neoplastic bile duct disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001173 ! biliary tree +relationship: disease_has_inflammation_site UBERON:0001173 ! biliary tree +property_value: exactMatch DOID:9446 +property_value: exactMatch http://identifiers.org/mesh/D002761 +property_value: exactMatch http://identifiers.org/snomedct/82403002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008311 +property_value: exactMatch https://icd.codes/icd10cm/K83.0 +property_value: exactMatch NCIT:C26718 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004796 +name: infectious meningitis +def: "Inflammation of the meninges of the brain and/or spinal cord caused by an infectious agent (viral, bacterial, or fungal). Symptoms include headache, fever, vomiting, neck stiffness, photophobia, confusion, and seizures." [NCIT:C79598] +synonym: "infectious meningitis" EXACT [NCIT:C79598] +synonym: "infective meningitis" EXACT [NCIT:C79598] +synonym: "meningitis" RELATED [DOID:9471] +xref: DOID:9471 {source="EFO:0000584", source="MONDO:equivalentTo"} +xref: EFO:0000584 {source="MONDO:equivalentTo"} +xref: HP:0001287 {source="MONDO:otherHierarchy"} +xref: ICD9:321.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:322 {source="EFO:0000584", source="DOID:9471"} +xref: ICD9:322.9 {source="EFO:0000584", source="DOID:9471"} +xref: MESH:D008581 {source="EFO:0000584", source="MONDO:equivalentTo", source="DOID:9471"} +xref: NCIT:C79598 {source="EFO:0000584", source="MONDO:equivalentTo"} +xref: SCTID:312216007 {source="MONDO:equivalentTo"} +is_a: MONDO:0021108 {source="MONDO:Redundant", source="NCIT:C79598"} ! meningitis +is_a: MONDO:0024619 ! central nervous system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0002360 ! meninx +relationship: disease_has_feature HP:0001287 ! Meningitis +relationship: disease_has_feature HP:0002315 {source="MONDO:Wikidata"} ! Headache +property_value: exactMatch DOID:9471 +property_value: exactMatch http://identifiers.org/mesh/D008581 +property_value: exactMatch http://identifiers.org/snomedct/312216007 +property_value: exactMatch NCIT:C79598 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004800 +name: chronic dacryoadenitis +def: "Chronic form of dacryoadenitis." [MONDO:patterns/chronic] +synonym: "dacryoadenitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:949 {source="MONDO:equivalentTo"} +xref: ICD9:375.02 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:949"} +xref: SCTID:4760008 {source="MONDO:equivalentTo", source="DOID:949"} +xref: UMLS:C0155224 {source="MONDO:equivalentTo", source="DOID:949"} +is_a: MONDO:0004804 {source="DOID:949", source="MONDO:Redundant"} ! dacryoadenitis +intersection_of: MONDO:0004804 ! dacryoadenitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:949 +property_value: exactMatch http://identifiers.org/snomedct/4760008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155224 + +[Term] +id: MONDO:0004804 +name: dacryoadenitis +def: "Inflammation and enlargement of the lacrimal gland." [NCIT:P378] +synonym: "inflammation of lacrimal gland" EXACT [] +synonym: "lacrimal gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:950 {source="MONDO:equivalentTo"} +xref: ICD9:375.0 {source="DOID:950"} +xref: ICD9:375.00 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:950"} +xref: MESH:D003607 {source="MONDO:directSiblingOf", source="DOID:950"} +xref: NCIT:C26971 {source="MONDO:equivalentTo", source="DOID:950"} +xref: SCTID:86927009 {source="MONDO:equivalentTo", source="DOID:950"} +xref: UMLS:C0155223 {source="NCIT:C26971", source="MONDO:equivalentTo", source="DOID:950"} +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0024625 ! disorder of lacrimal gland +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001817 ! lacrimal gland +relationship: disease_has_inflammation_site UBERON:0001817 ! lacrimal gland +property_value: exactMatch DOID:950 +property_value: exactMatch http://identifiers.org/snomedct/86927009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155223 +property_value: exactMatch NCIT:C26971 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004805 +name: leukocyte disorder +def: "A disease involving leukocytes." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of leukocyte" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of leukocyte" EXACT [] +synonym: "disorder of leukocyte" EXACT [MONDO:patterns/location_top] +synonym: "disorder, leukocyte" EXACT [MESH:D007960] +synonym: "disorders, leukocyte" EXACT [MESH:D007960] +synonym: "leukocyte disease" EXACT [MONDO:patterns/location] +synonym: "leukocyte disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "leukocyte disorder" EXACT [MESH:D007960] +synonym: "white blood cell disorder" EXACT [] +xref: DOID:9500 {source="MONDO:equivalentTo"} +xref: ICD9:288 {source="DOID:9500"} +xref: ICD9:288.9 {source="DOID:9500"} +xref: MESH:D007960 {source="MONDO:equivalentTo", source="DOID:9500"} +xref: SCTID:54097007 {source="MONDO:equivalentTo", source="DOID:9500"} +xref: UMLS:C0023510 {source="MONDO:equivalentTo", source="DOID:9500"} +is_a: MONDO:0005046 ! immune system disorder +is_a: MONDO:0005570 {source="DOID:9500", source="MESH:D007960"} ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location CL:0000738 ! leukocyte +relationship: disease_has_location CL:0000738 ! leukocyte +property_value: exactMatch DOID:9500 +property_value: exactMatch http://identifiers.org/mesh/D007960 +property_value: exactMatch http://identifiers.org/snomedct/54097007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023510 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004810 +name: acute ethmoiditis +def: "Acute form of ethmoid sinusitis." [MONDO:patterns/acute] +synonym: "acute ethmoid sinusitis" EXACT [DOID:9506] +synonym: "acute ethmoidal sinusitis" EXACT [DOID:9506, ICD9CM:461.2] +synonym: "ethmoid sinusitis, acute" EXACT [MONDO:patterns/acute] +synonym: "ethmoidal sinus - acute" EXACT [DOID:9506] +xref: DOID:9506 {source="MONDO:equivalentTo"} +xref: ICD9:461.2 {source="DOID:9506", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:67832005 {source="DOID:9506", source="MONDO:equivalentTo"} +xref: UMLS:C0155806 {source="DOID:9506", source="MONDO:equivalentTo"} +is_a: MONDO:0005756 {source="DOID:9506", source="MONDO:Redundant"} ! ethmoid sinusitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0005756 ! ethmoid sinusitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:9506 +property_value: exactMatch http://identifiers.org/snomedct/67832005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155806 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0004812 +name: acute dacryoadenitis +def: "Acute form of dacryoadenitis." [MONDO:patterns/acute] +synonym: "dacryoadenitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:952 {source="MONDO:equivalentTo"} +xref: ICD9:375.01 {source="DOID:952", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:2589008 {source="DOID:952", source="MONDO:equivalentTo"} +xref: UMLS:C0149505 {source="DOID:952", source="MONDO:equivalentTo"} +is_a: MONDO:0004804 {source="DOID:952", source="MONDO:Redundant"} ! dacryoadenitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004804 ! dacryoadenitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:952 +property_value: exactMatch http://identifiers.org/snomedct/2589008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149505 + +[Term] +id: MONDO:0004820 +name: peripheral nerve schwannoma +def: "A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported." [NCIT:P378] +synonym: "peripheral nerve schwannoma" EXACT [NCIT:C41430] +xref: DOID:956 {source="MONDO:equivalentTo"} +xref: NCIT:C41430 {source="DOID:956", source="MONDO:equivalentTo", source="NCIT:C41430"} +xref: UMLS:C1519001 {source="DOID:956", source="MONDO:equivalentTo", source="NCIT:C41430"} +is_a: MONDO:0002546 {source="DOID:956", source="NCIT:C41430"} ! schwannoma +property_value: exactMatch DOID:956 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519001 +property_value: exactMatch NCIT:C41430 + +[Term] +id: MONDO:0004821 +name: nasopharyngeal disorder +def: "A non-neoplastic or neoplastic disorder that affects the nasopharynx. Representative examples include nasopharyngitis, angiofibroma, and carcinoma." [NCIT:P378] +synonym: "disease of nasopharynx" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nasopharynx" EXACT [] +synonym: "disorder of nasopharynx" EXACT [MONDO:patterns/location_top] +synonym: "disorder of postnasal space" RELATED [] +synonym: "nasopharyngeal disorder" EXACT [NCIT:C35723] +synonym: "nasopharynx disease" EXACT [MONDO:patterns/location] +synonym: "nasopharynx disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:9561 {source="MONDO:equivalentTo"} +xref: MESH:D009302 {source="MONDO:equivalentTo", source="DOID:9561"} +xref: NCIT:C35723 {source="MONDO:equivalentTo", source="DOID:9561"} +xref: SCTID:123952009 {source="MONDO:equivalentTo", source="DOID:9561"} +xref: UMLS:C0027438 {source="MONDO:equivalentTo", source="DOID:9561"} +is_a: MONDO:0004867 {source="DOID:9561", source="MONDO:Redundant"} ! upper respiratory tract disorder +is_a: MONDO:0020592 ! disorder of pharynx +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001728 ! nasopharynx +relationship: disease_has_location UBERON:0001728 ! nasopharynx +property_value: exactMatch DOID:9561 +property_value: exactMatch http://identifiers.org/mesh/D009302 +property_value: exactMatch http://identifiers.org/snomedct/123952009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027438 +property_value: exactMatch NCIT:C35723 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004830 +name: fasciitis +def: "Inflammation process in fascia." [NCIT:P378] +synonym: "fascia inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "fasciitis" EXACT [MONDO:ambiguous] +synonym: "fasciitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "Fascitis" EXACT [NCIT:C50559] +synonym: "inflammation of fascia" EXACT [] +xref: DOID:9598 {source="MONDO:equivalentTo"} +xref: HP:0100537 {source="MONDO:otherHierarchy"} +xref: ICD9:729.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9598"} +xref: MESH:D005208 {source="MONDO:equivalentTo", source="DOID:9598"} +xref: NCIT:C50559 {source="MONDO:equivalentTo", source="DOID:9598"} +xref: SCTID:36948007 {source="MONDO:equivalentTo", source="DOID:9598"} +xref: UMLS:C0015645 {source="NCIT:C50559", source="MONDO:equivalentTo", source="DOID:9598"} +is_a: MONDO:0002081 ! musculoskeletal system disorder +is_a: MONDO:0003900 {source="DOID:9598", source="MONDO:Redundant"} ! connective tissue disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0008982 ! fascia +relationship: disease_has_inflammation_site UBERON:0008982 ! fascia +property_value: exactMatch DOID:9598 +property_value: exactMatch http://identifiers.org/mesh/D005208 +property_value: exactMatch http://identifiers.org/snomedct/36948007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015645 +property_value: exactMatch NCIT:C50559 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "fasciitis (disease)" xsd:string + +[Term] +id: MONDO:0004842 +name: stomatitis +def: "Inflammation of the oral mucosa due to local or systemic factors." [NCIT:P378] +synonym: "inflammation of mouth mucosa" EXACT [] +synonym: "mouth mucosa inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "mucositis oral" EXACT [NCIT:C26887] +synonym: "oral mucositis" EXACT [NCIT:C26887] +xref: DOID:9637 {source="MONDO:equivalentTo"} +xref: EFO:1001904 {source="MONDO:equivalentTo"} +xref: ICD9:528.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:528.00 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D013280 {source="DOID:9637", source="MONDO:equivalentTo"} +xref: NCIT:C26887 {source="DOID:9637", source="MONDO:equivalentTo"} +xref: SCTID:61170000 {source="DOID:9637", source="MONDO:equivalentTo"} +xref: UMLS:C0038362 {source="DOID:9637", source="MONDO:equivalentTo"} +xref: UMLS:C1568868 {source="MONDO:equivalentTo", source="NCIT:C26887"} +is_a: MONDO:0020579 ! mucositis +is_a: MONDO:0044992 ! mouth mucosa disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0003729 ! mouth mucosa +relationship: disease_has_inflammation_site UBERON:0003729 ! mouth mucosa +property_value: exactMatch DOID:9637 +property_value: exactMatch http://identifiers.org/mesh/D013280 +property_value: exactMatch http://identifiers.org/snomedct/61170000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038362 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1568868 +property_value: exactMatch NCIT:C26887 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004855 +name: tenosynovitis +def: "Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced." [MESH:D013717] +synonym: "Inflammation of tendon sheath" EXACT [DOID:970] +synonym: "inflammation of tendon sheath" EXACT [] +synonym: "tendon sheath inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "Tenosynovitides" EXACT [MESH:D013717] +xref: DOID:970 {source="MONDO:equivalentTo"} +xref: EFO:1001435 {source="MONDO:equivalentTo"} +xref: MESH:D013717 {source="MONDO:equivalentTo", source="DOID:970"} +xref: SCTID:67801009 {source="MONDO:equivalentTo", source="DOID:970"} +xref: UMLS:C0039520 {source="MONDO:equivalentTo", source="DOID:970"} +is_a: MONDO:0004857 {source="DOID:970", source="MESH:D013717", source="MONDO:Redundant"} ! tendinitis +is_a: MONDO:0006816 {source="DOID:970"} ! arthropathy +is_a: MONDO:0024876 ! tendon sheath disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000304 ! tendon sheath +relationship: disease_has_inflammation_site UBERON:0000304 ! tendon sheath +property_value: exactMatch DOID:970 +property_value: exactMatch http://identifiers.org/mesh/D013717 +property_value: exactMatch http://identifiers.org/snomedct/67801009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039520 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004857 +name: tendinitis +def: "Inflammation of a tendon, usually resulting from an overuse injury. It is characterized by swelling of the tendon, tenderness around the inflamed tendon, and pain while moving the affected area of the body." [NCIT:C97141] +synonym: "inflammation of tendon" EXACT [] +synonym: "tendon inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "tendonitis" EXACT [MONDO:patterns/inflammatory_disease_by_site, NCIT:C97141] +xref: DOID:971 {source="MONDO:equivalentTo"} +xref: MESH:D052256 {source="MONDO:equivalentTo", source="DOID:971"} +xref: NCIT:C97141 {source="MONDO:equivalentTo", source="DOID:971"} +xref: SCTID:34840004 {source="MONDO:equivalentTo", source="DOID:971"} +xref: UMLS:C0039503 {source="MONDO:equivalentTo", source="NCIT:C97141", source="DOID:971"} +is_a: MONDO:0021167 {source="DOID:971"} ! myositis +is_a: MONDO:0100010 ! tendinopathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000043 ! tendon +relationship: disease_has_inflammation_site UBERON:0000043 ! tendon +property_value: exactMatch DOID:971 +property_value: exactMatch http://identifiers.org/mesh/D052256 +property_value: exactMatch http://identifiers.org/snomedct/34840004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039503 +property_value: exactMatch NCIT:C97141 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004860 +name: vitreous disorder +def: "A disease involving the vitreous humor." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of vitreous humor" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vitreous humor" EXACT [] +synonym: "disorder of vitreous humor" EXACT [MONDO:patterns/location_top] +synonym: "vitreous humor disease" EXACT [MONDO:patterns/location] +synonym: "vitreous humor disease or disorder" EXACT [MONDO:patterns/location] +xref: DOID:9720 {source="MONDO:equivalentTo"} +xref: ICD9:379.24 {source="DOID:9720"} +is_a: MONDO:0044137 ! vitreous body disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001797 ! vitreous humor +relationship: disease_has_location UBERON:0001797 ! vitreous humor +property_value: exactMatch DOID:9720 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004863 +name: purulent endophthalmitis +xref: DOID:9724 {source="MONDO:equivalentTo"} +xref: ICD10CM:H44.0 {source="DOID:9724", source="MONDO:equivalentTo"} +xref: ICD9:360.0 {source="DOID:9724"} +xref: ICD9:360.00 {source="DOID:9724", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:41720003 {source="DOID:9724", source="MONDO:equivalentTo"} +xref: UMLS:C0259800 {source="DOID:9724", source="MONDO:equivalentTo"} +is_a: MONDO:0016047 {source="DOID:9724"} ! endophthalmitis +property_value: exactMatch DOID:9724 +property_value: exactMatch http://identifiers.org/snomedct/41720003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0259800 +property_value: exactMatch https://icd.codes/icd10cm/H44.0 + +[Term] +id: MONDO:0004866 +name: eustachian tube disorder +def: "A disease involving the pharyngotympanic tube." [MONDO:patterns/location_top] +synonym: "auditory tube disorder" RELATED [] +synonym: "disease of eustachian tube" RELATED [] +synonym: "disease of pharyngotympanic tube" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of pharyngotympanic tube" EXACT [] +synonym: "disorder of eustachian tube" RELATED [] +synonym: "disorder of pharyngotympanic tube" EXACT [MONDO:patterns/location_top] +synonym: "eustachian tube disorder" EXACT [] +synonym: "pharyngotympanic tube disease" EXACT [MONDO:patterns/location] +synonym: "pharyngotympanic tube disease or disorder" EXACT [MONDO:patterns/location] +xref: DOID:9739 {source="MONDO:equivalentTo"} +xref: ICD10CM:H68 {source="MONDO:equivalentTo"} +xref: ICD9:381.8 {source="DOID:9739"} +xref: ICD9:381.89 {source="MONDO:relatedTo", source="DOID:9739", source="MONDO:i2s"} +xref: ICD9:381.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:69494008 {source="MONDO:equivalentTo"} +xref: UMLS:C0271468 {source="MONDO:equivalentTo"} +is_a: MONDO:0003276 ! middle ear disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002393 ! pharyngotympanic tube +relationship: disease_has_location UBERON:0002393 ! pharyngotympanic tube +property_value: exactMatch DOID:9739 +property_value: exactMatch http://identifiers.org/snomedct/69494008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271468 +property_value: exactMatch https://icd.codes/icd10cm/H68 +property_value: excluded_subClassOf MONDO:0001212 {source="DOID:9739"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004867 +name: upper respiratory tract disorder +def: "A disease involving the upper respiratory tract." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of upper respiratory tract" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of upper respiratory tract" EXACT [] +synonym: "disorder of upper respiratory tract" EXACT [MONDO:patterns/location_top] +synonym: "upper respiratory tract disease" EXACT [MONDO:patterns/location] +synonym: "upper respiratory tract disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:974 {source="MONDO:equivalentTo"} +xref: ICD9:478.1 {source="DOID:974"} +xref: ICD9:478.19 {source="DOID:974"} +xref: ICD9:478.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:201060008 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 {source="DOID:974", source="MONDO:Redundant"} ! respiratory system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001557 ! upper respiratory tract +relationship: disease_has_location UBERON:0001557 ! upper respiratory tract +property_value: exactMatch DOID:974 +property_value: exactMatch http://identifiers.org/snomedct/201060008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004868 +name: biliary tract disorder +def: "A disease involving the biliary tree." [https://orcid.org/0000-0002-6601-2165] +synonym: "biliary tree disease" EXACT [MONDO:patterns/location] +synonym: "biliary tree disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of biliary tree" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of biliary tree" EXACT [] +synonym: "disorder of biliary tree" EXACT [MONDO:patterns/location_top] +xref: DOID:9741 {source="MONDO:equivalentTo"} +xref: ICD9:576.9 {source="DOID:9741"} +xref: MESH:D001660 {source="MONDO:equivalentTo", source="DOID:9741"} +xref: SCTID:105997008 {source="MONDO:equivalentTo", source="DOID:9741"} +is_a: MONDO:0002515 {source="DOID:9741", source="MONDO:Entailed", source="MONDO:Redundant"} ! hepatobiliary disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001173 ! biliary tree +relationship: disease_has_location UBERON:0001173 ! biliary tree +property_value: exactMatch DOID:9741 +property_value: exactMatch http://identifiers.org/mesh/D001660 +property_value: exactMatch http://identifiers.org/snomedct/105997008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004880 +name: bowel dysfunction +def: "Any disease in which the causes of the disease is a perturbation of the lower digestive tract leading to its dysfunction." [MONDO:patterns/disease_by_dysfunctional_structure] +synonym: "disease of lower digestive tract" EXACT [MONDO:design_pattern, MONDO:patterns/disease_by_dysfunctional_structure] +synonym: "lower digestive tract disease" EXACT [MONDO:design_pattern] +xref: DOID:9779 {source="MONDO:equivalentTo"} +xref: ICD9:564.9 {source="DOID:9779"} +xref: SCTID:235594008 {source="MONDO:equivalentTo"} +xref: UMLS:C2004461 {source="MONDO:equivalentTo"} +is_a: MONDO:0005020 {source="DOID:9779"} ! intestinal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0004907 ! lower digestive tract +relationship: disease_has_basis_in_dysfunction_of UBERON:0004907 ! lower digestive tract +property_value: exactMatch DOID:9779 +property_value: exactMatch http://identifiers.org/snomedct/235594008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2004461 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/disease_by_dysfunctional_structure.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0004884 +name: eye degenerative disorder +def: "A neurodegenerative disease that involves the eye." [MONDO:patterns/location] +synonym: "degenerative disorder of eye" EXACT [] +synonym: "degenerative disorder of globe" RELATED [] +synonym: "eye neurodegenerative disease" EXACT [MONDO:patterns/location] +synonym: "eyeball of camera-type eye neurodegenerative disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "neurodegenerative disease of eyeball of camera-type eye" EXACT [MONDO:design_pattern] +xref: DOID:9799 {source="MONDO:equivalentTo"} +xref: ICD10CM:H44.5 {source="DOID:9799", source="MONDO:equivalentTo"} +xref: ICD9:360.2 {source="DOID:9799"} +xref: ICD9:360.20 {source="DOID:9799", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:360.29 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:360.4 {source="DOID:9799"} +xref: ICD9:360.40 {source="DOID:9799"} +xref: SCTID:62585004 {source="DOID:9799", source="MONDO:equivalentTo"} +xref: UMLS:C0154777 {source="DOID:9799", source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="DOID:9799", source="MONDO:Redundant"} ! eye disorder +is_a: MONDO:0005559 {source="DOID:9799", source="MONDO:Redundant"} ! neurodegenerative disease +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch DOID:9799 +property_value: exactMatch http://identifiers.org/snomedct/62585004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154777 +property_value: exactMatch https://icd.codes/icd10cm/H44.5 + +[Term] +id: MONDO:0004885 +name: choroidal sclerosis +def: "A neurodegenerative disease that involves the optic choroid." [MONDO:patterns/location] +synonym: "choroidal degenerations" EXACT [DOID:980, ICD9CM:363.4] +synonym: "neurodegenerative disease of optic choroid" EXACT [MONDO:design_pattern] +synonym: "optic choroid neurodegenerative disease" EXACT [MONDO:patterns/location] +xref: DOID:980 {source="MONDO:equivalentTo"} +xref: ICD9:363.4 {source="DOID:980"} +xref: ICD9:363.40 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:980"} +xref: MESH:C535358 {source="MONDO:equivalentTo", source="DOID:980"} +xref: OMIM:215500 {source="DOID:980", source="MONDO:directSiblingOf"} +xref: SCTID:406446000 {source="MONDO:equivalentTo", source="DOID:980"} +is_a: MONDO:0001898 {source="MESH:C535358", source="MONDO:Redundant"} ! optic choroid disorder +is_a: MONDO:0004884 {source="DOID:980", source="MONDO:Redundant"} ! eye degenerative disorder +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_has_location UBERON:0001776 ! optic choroid +property_value: exactMatch DOID:980 +property_value: exactMatch http://identifiers.org/mesh/C535358 +property_value: exactMatch http://identifiers.org/snomedct/406446000 + +[Term] +id: MONDO:0004892 +name: refractive error +def: "A defect in the focusing of light on the retina as in astigmatism, myopia, or hyperopia." [NCIT:P378] +xref: DOID:9835 {source="MONDO:equivalentTo"} +xref: MESH:D012030 {source="DOID:9835", source="MONDO:equivalentTo"} +xref: NCIT:C87145 {source="DOID:9835", source="MONDO:otherHierarchy"} +xref: SCTID:39021009 {source="DOID:9835", source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="DOID:9835", source="MESH:D012030"} ! eye disorder +property_value: exactMatch DOID:9835 +property_value: exactMatch http://identifiers.org/mesh/D012030 +property_value: exactMatch http://identifiers.org/snomedct/39021009 +property_value: relatedMatch NCIT:C87145 + +[Term] +id: MONDO:0004917 +name: internal hordeolum +def: "A hordeolum that results from infection of a meibomian gland." [https://www.merckmanuals.com/professional/eye-disorders/eyelid-and-lacrimal-disorders/chalazion-and-hordeolum-stye] +synonym: "hordeolum internum" RELATED [] +synonym: "hordeolum of tarsal gland" EXACT [MONDO:design_pattern] +synonym: "infected chalazion" RELATED [] +synonym: "infected cyst of meibomian gland" RELATED [] +synonym: "infected meibomian cyst" RELATED [] +synonym: "infection of meibomian gland" RELATED [] +synonym: "internal hordeolum" EXACT [] +synonym: "meibomian adenitis" RELATED [] +synonym: "tarsal gland hordeolum" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:9908 {source="MONDO:equivalentTo"} +xref: ICD9:373.12 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9908"} +xref: SCTID:414521009 {source="MONDO:equivalentTo", source="DOID:9908"} +xref: UMLS:C0085690 {source="MONDO:equivalentTo", source="DOID:9908"} +is_a: MONDO:0005800 {source="DOID:9908", source="MONDO:Redundant"} ! hordeolum +is_a: MONDO:0006607 ! sebaceous gland disorder +intersection_of: MONDO:0005800 ! hordeolum +intersection_of: disease_has_location UBERON:0001818 ! tarsal gland +relationship: disease_has_location UBERON:0001818 ! tarsal gland +property_value: exactMatch DOID:9908 +property_value: exactMatch http://identifiers.org/snomedct/414521009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085690 + +[Term] +id: MONDO:0004923 +name: chronic inflammation of lacrimal passage +xref: DOID:9935 {source="MONDO:equivalentTo"} +xref: ICD9:375.4 {source="DOID:9935"} +xref: SCTID:267653001 {source="DOID:9935", source="MONDO:equivalentTo"} +xref: UMLS:C0155239 {source="DOID:9935", source="MONDO:equivalentTo"} +is_a: MONDO:0001854 {source="DOID:9935", source="MONDO:Redundant"} ! lacrimal apparatus disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001850 ! lacrimal drainage system +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: disease_has_inflammation_site UBERON:0001850 ! lacrimal drainage system +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:9935 +property_value: exactMatch http://identifiers.org/snomedct/267653001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155239 + +[Term] +id: MONDO:0004925 +name: chronic dacryocystitis +def: "Chronic form of dacryocystitis." [MONDO:patterns/chronic] +synonym: "dacryocystitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:9937 {source="MONDO:equivalentTo"} +xref: ICD9:375.42 {source="DOID:9937", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:84627005 {source="DOID:9937", source="MONDO:equivalentTo"} +xref: UMLS:C0149506 {source="DOID:9937", source="MONDO:equivalentTo"} +is_a: MONDO:0004923 {source="DOID:9937", source="MONDO:Redundant"} ! chronic inflammation of lacrimal passage +is_a: MONDO:0004926 {source="DOID:9937", source="MONDO:Redundant"} ! dacryocystitis +intersection_of: MONDO:0004926 ! dacryocystitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:9937 +property_value: exactMatch http://identifiers.org/snomedct/84627005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149506 + +[Term] +id: MONDO:0004926 +name: dacryocystitis +def: "Inflammation of the lacrimal sac." [NCIT:P378] +synonym: "Dacryoadenitides" EXACT [MESH:D003607] +synonym: "dacryoadenitis" RELATED [MESH:D003607] +synonym: "Dacryocystitides" EXACT [MESH:D003607] +synonym: "inflammation of lacrimal sac" EXACT [] +synonym: "lacrimal sac inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:9938 {source="MONDO:equivalentTo"} +xref: ICD9:375.30 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9938"} +xref: MESH:D003607 {source="MONDO:equivalentTo", source="DOID:9938"} +xref: NCIT:C34521 {source="MONDO:equivalentTo", source="DOID:9938"} +xref: SCTID:85777005 {source="MONDO:equivalentTo", source="DOID:9938"} +xref: UMLS:C0010930 {source="MONDO:equivalentTo", source="NCIT:C34521", source="DOID:9938"} +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +is_a: MONDO:0044984 ! nasolacrimal duct disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001351 ! lacrimal sac +relationship: disease_has_inflammation_site UBERON:0001351 ! lacrimal sac +property_value: exactMatch DOID:9938 +property_value: exactMatch http://identifiers.org/mesh/D003607 +property_value: exactMatch http://identifiers.org/snomedct/85777005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010930 +property_value: exactMatch NCIT:C34521 +property_value: excluded_subClassOf MONDO:0004055 {source="DOID:9938"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004928 +name: lymph node disorder +def: "Any disorder of the lymph nodes." [NCIT:C35346] +synonym: "disease of lymph node" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lymph node" EXACT [] +synonym: "disorder of lymph node" EXACT [MONDO:patterns/location_top] +synonym: "lymph node disease" EXACT [MONDO:patterns/location] +synonym: "lymph node disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lymph node disorder" EXACT [NCIT:C35346] +xref: DOID:9942 {source="MONDO:equivalentTo"} +xref: NCIT:C35346 {source="DOID:9942", source="MONDO:equivalentTo"} +xref: SCTID:76616003 {source="DOID:9942", source="MONDO:equivalentTo"} +xref: UMLS:C0272394 {source="DOID:9942", source="MONDO:equivalentTo", source="NCIT:C35346"} +is_a: MONDO:0005833 {source="DOID:9942"} ! lymphatic system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000029 ! lymph node +relationship: disease_has_location UBERON:0000029 ! lymph node +property_value: exactMatch DOID:9942 +property_value: exactMatch http://identifiers.org/snomedct/76616003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0272394 +property_value: exactMatch NCIT:C35346 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0004934 +name: periostitis +def: "Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)" [MESH:D010522] +synonym: "inflammation of periosteum" EXACT [] +synonym: "periosteum" EXACT [NCIT:C13184] +synonym: "periosteum inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "periostitis" EXACT [MONDO:ambiguous] +synonym: "periostitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:9957 {source="MONDO:equivalentTo"} +xref: HP:0040165 {source="MONDO:otherHierarchy"} +xref: MESH:D010522 {source="DOID:9957", source="MONDO:equivalentTo"} +xref: NCIT:C13184 {source="MONDO:equivalentTo"} +xref: SCTID:41910004 {source="DOID:9957", source="MONDO:equivalentTo"} +xref: UMLS:C0031111 {source="DOID:9957", source="MONDO:equivalentTo"} +is_a: MONDO:0003900 {source="DOID:9957", source="MONDO:Redundant"} ! connective tissue disorder +is_a: MONDO:0005381 {source="MESH:D010522/inferred", source="MONDO:Redundant"} ! bone disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002515 ! periosteum +relationship: disease_has_inflammation_site UBERON:0002515 ! periosteum +property_value: exactMatch DOID:9957 +property_value: exactMatch http://identifiers.org/mesh/D010522 +property_value: exactMatch http://identifiers.org/snomedct/41910004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031111 +property_value: exactMatch NCIT:C13184 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "periostitis (disease)" xsd:string + +[Term] +id: MONDO:0004938 +name: substance dependence +def: "The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence." [NCIT:P378] +synonym: "dependence" EXACT [NCIT:C35458] +xref: DOID:9973 {source="MONDO:equivalentTo"} +xref: ICD9:304.60 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C35458 {source="MONDO:equivalentTo", source="DOID:9973"} +xref: SCTID:2403008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002494 {source="DOID:9973"} ! substance-related disorder +property_value: exactMatch DOID:9973 +property_value: exactMatch http://identifiers.org/snomedct/2403008 +property_value: exactMatch NCIT:C35458 + +[Term] +id: MONDO:0004949 +name: neoplasm of mature B-cells +def: "A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)." [NCIT:P378] +comment: Editor note: is a non-hodgkin in ONCOTREE +synonym: "mature B-cell lymphocytic neoplasm" EXACT [DOID:706, NCIT:C27910] +synonym: "mature B-cell neoplasm" EXACT [NCIT:C27910] +synonym: "mature B-cell neoplasms" RELATED [ONCOTREE:MBN] +xref: DOID:706 {source="MONDO:equivalentTo"} +xref: EFO:0000096 {source="MONDO:equivalentTo", source="DOID:706"} +xref: ICD9:202.0 {source="EFO:0000096"} +xref: NCIT:C27910 {source="MONDO:equivalentTo", source="DOID:706"} +xref: NCIT:C3457 {source="EFO:0000096", source="MONDO:directSiblingOf"} +xref: ONCOTREE:MBN {source="MONDO:equivalentTo"} +xref: SCTID:269476000 {source="EFO:0000096", source="MONDO:equivalentTo"} +xref: UMLS:C1334633 {source="MONDO:equivalentTo", source="NCIT:C27910", source="DOID:706"} +is_a: MONDO:0004095 {source="DOID:706", source="NCIT:C27910"} ! B-cell neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000785 ! mature B cell +relationship: disease_arises_from_structure CL:0000785 ! mature B cell +property_value: exactMatch DOID:706 +property_value: exactMatch http://identifiers.org/snomedct/269476000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334633 +property_value: exactMatch NCIT:C27910 + +[Term] +id: MONDO:0004950 +name: gastric carcinoma +def: "A carcinoma that arises from epithelial cells of the stomach." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca fundus - stomach" NARROW [DOID:10538] +synonym: "cancer of fundus of stomach" NARROW [MONDO:patterns/cancer] +synonym: "cancer of stomach" BROAD [NCIT:C4911] +synonym: "cancer of the stomach" BROAD [DOID:5517, NCIT:C4911] +synonym: "carcinoma of stomach" EXACT [DOID:5517, MONDO:patterns/carcinoma, NCIT:C4911] +synonym: "carcinoma of the stomach" EXACT [NCIT:C4911] +synonym: "fundus of stomach cancer" NARROW [MONDO:patterns/location] +synonym: "gastric (stomach) cancer" BROAD [NCIT:C4911] +synonym: "gastric cancer" BROAD [NCIT:C4911] +synonym: "gastric cancer, NOS" BROAD [NCIT:C4911] +synonym: "gastric carcinoma" EXACT [DOID:5517, NCIT:C4911] +synonym: "gastric fundus cancer" NARROW [DOID:10538] +synonym: "malignant fundus of stomach neoplasm" NARROW [MONDO:patterns/cancer] +synonym: "malignant neoplasm of fundus of stomach" NARROW [DOID:10538, ICD9CM:151.3, MONDO:patterns/cancer] +synonym: "malignant tumor of fundus of stomach" NARROW [DOID:10538] +synonym: "stomach cancer" BROAD [NCIT:C4911] +synonym: "stomach carcinoma" EXACT [MONDO:patterns/location, NCIT:C4911] +xref: DOID:10538 {source="MONDO:equivalentTo"} +xref: DOID:5517 {source="MONDO:equivalentTo"} +xref: EFO:0000178 {source="MONDO:equivalentTo", source="DOID:5517"} +xref: ICD9:151.3 {source="MONDO:equivalentTo", source="DOID:10538", source="MONDO:i2s"} +xref: ICD9:230.2 {source="MONDO:relatedTo", source="EFO:0000178"} +xref: NCIT:C4911 {source="EFO:0000178", source="MONDO:equivalentTo", source="DOID:5517"} +xref: SCTID:187741001 {source="MONDO:equivalentTo", source="DOID:10538"} +xref: UMLS:C0153420 {source="MONDO:equivalentTo", source="DOID:10538"} +xref: UMLS:C0699791 {source="MONDO:equivalentTo", source="DOID:5517", source="NCIT:C4911"} +is_a: MONDO:0001056 {source="DOID:5517", source="MONDO:Redundant", source="NCIT:C4911"} ! gastric cancer +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C4911"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:10538 +property_value: exactMatch DOID:5517 +property_value: exactMatch http://identifiers.org/snomedct/187741001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153420 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0699791 +property_value: exactMatch NCIT:C4911 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004953 +name: invasive ductal breast carcinoma +def: "The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both." [NCIT:P378] +synonym: "breast invasive ductal carcinoma" RELATED [ONCOTREE:IDC] +synonym: "ductal adenocarcinoma" EXACT [DOID:3008, NCIT:C4017] +synonym: "infiltrating ductal adenocarcinoma" EXACT [NCIT:C4194] +synonym: "infiltrating ductal breast carcinoma" EXACT [NCIT:C4194] +synonym: "infiltrating ductal carcinoma" EXACT [NCIT:C4194] +synonym: "infiltrating ductal carcinoma of breast" EXACT [DOID:3008, NCIT:C4194] +synonym: "infiltrating ductal carcinoma of the breast" EXACT [NCIT:C4194] +synonym: "invasive ductal adenocarcinoma" EXACT [NCIT:C4194] +synonym: "invasive ductal breast carcinoma" EXACT [NCIT:C4194] +synonym: "invasive ductal carcinoma" EXACT [NCIT:C4194] +synonym: "invasive ductal carcinoma of breast" EXACT [NCIT:C4194] +synonym: "invasive ductal carcinoma of the breast" EXACT [NCIT:C4194] +synonym: "invasive ductal carcinoma, No specific type" EXACT [NCIT:C4194] +synonym: "invasive ductal carcinoma, NST" EXACT [DOID:3008, NCIT:C4194] +xref: DOID:3008 {source="EFO:0000186", source="MONDO:equivalentTo"} +xref: EFO:0000186 {source="MONDO:equivalentTo"} +xref: ICD9:174.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8500/3 {source="NCIT:C4194"} +xref: ICDO:8521/3 {source="NCIT:C4194"} +xref: NCIT:C4194 {source="EFO:0000186", source="MONDO:equivalentTo", source="DOID:3008"} +xref: ONCOTREE:IDC {source="MONDO:equivalentTo"} +xref: SCTID:408643008 {source="MONDO:equivalentTo", source="DOID:3008"} +is_a: MONDO:0005590 {source="DOID:3008", source="MONDO:Redundant", source="NCIT:C4194"} ! breast ductal adenocarcinoma +is_a: MONDO:0006256 {source="MONDO:Redundant", source="NCIT:C4194", source="ONCOTREE:IDC"} ! invasive breast carcinoma +intersection_of: MONDO:0005590 ! breast ductal adenocarcinoma +intersection_of: has_modifier PATO:0002129 ! neoplastic, invasive +property_value: exactMatch DOID:3008 +property_value: exactMatch http://identifiers.org/snomedct/408643008 +property_value: exactMatch NCIT:C4194 + +[Term] +id: MONDO:0004958 +name: oral cavity squamous cell carcinoma +def: "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status." [NCIT:C4833] +subset: gard_rare {source="GARD:0007263"} +subset: ordo_disease +synonym: "mouth scc" EXACT [NCIT:C4833] +synonym: "mouth squamous cell carcinoma" EXACT [DOID:0050866, MONDO:patterns/location, NCIT:C4833] +synonym: "OCSC" RELATED ABBREVIATION [ONCOTREE:OCSC] +synonym: "oral cavity scc" EXACT [NCIT:C4833] +synonym: "oral cavity squamous cell cancer" EXACT [NCIT:C4833] +synonym: "oral cavity squamous cell carcinoma" EXACT [NCIT:C4833] +synonym: "oral squamous cell carcinoma" RELATED [DOID:0050866, GARD:0007263] +synonym: "scc of mouth" EXACT [NCIT:C4833] +synonym: "scc of oral cavity" EXACT [NCIT:C4833] +synonym: "scc of the mouth" EXACT [NCIT:C4833] +synonym: "scc of the oral cavity" EXACT [NCIT:C4833] +synonym: "squamous cell carcinoma of mouth" EXACT [NCIT:C4833] +synonym: "squamous cell carcinoma of oral cavity" EXACT [NCIT:C4833] +synonym: "squamous cell carcinoma of the mouth" EXACT [NCIT:C4833] +synonym: "squamous cell carcinoma of the oral cavity" EXACT [NCIT:C4833] +xref: DOID:0050866 {source="EFO:0000199", source="MONDO:equivalentTo"} +xref: EFO:0000199 {source="MONDO:equivalentTo"} +xref: GARD:0007263 {source="MONDO:equivalentTo"} +xref: NCIT:C4833 {source="EFO:0000199", source="MONDO:equivalentTo"} +xref: ONCOTREE:OCSC {source="MONDO:equivalentTo"} +xref: Orphanet:502363 {source="MONDO:equivalentTo"} +xref: SCTID:307502000 {source="EFO:0000199", source="MONDO:equivalentTo"} +xref: UMLS:C0585362 {source="MONDO:equivalentTo", source="NCIT:C4833"} +is_a: MONDO:0044710 ! lip and oral cavity squamous cell carcinoma +is_a: MONDO:0044925 ! oral cavity carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000165 ! mouth +property_value: exactMatch DOID:0050866 +property_value: exactMatch http://identifiers.org/snomedct/307502000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0585362 +property_value: exactMatch NCIT:C4833 +property_value: exactMatch Orphanet:502363 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7263/oral-squamous-cell-carcinoma xsd:anyURI {source="GARD:0007263"} + +[Term] +id: MONDO:0004959 +name: plasma cell neoplasm +def: "A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance." [NCIT:C4665] +comment: See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/39 +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98282"} +synonym: "plasma cell disorder" RELATED [] +synonym: "plasma cell dyscrasia" EXACT [NCIT:C4665] +synonym: "plasma cell neoplasm" EXACT [NCIT:C4665] +synonym: "plasma cell tumor" EXACT [MONDO:0020079, NCIT:C4665] +synonym: "plasma cell tumor, malignant" EXACT [NCIT:C4665] +synonym: "plasma cell tumour" EXACT [DOID:6536] +synonym: "plasmacytic neoplasm" EXACT [NCIT:C4665] +synonym: "plasmacytic tumor" EXACT [DOID:6536, NCIT:C4665] +synonym: "plasmacytic tumour" EXACT [NCIT:C4665] +xref: DOID:6536 {source="EFO:0000200", source="MONDO:equivalentTo"} +xref: EFO:0000200 {source="DOID:6536", source="MONDO:equivalentTo"} +xref: ICD9:238.6 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D054219 {source="MONDO:equivalentTo"} +xref: NCIT:C4665 {source="EFO:0000200", source="MONDO:equivalentTo"} +xref: Orphanet:98282 {source="MONDO:equivalentTo"} +xref: SCTID:415111003 {source="EFO:0000200", source="MONDO:equivalentTo"} +xref: UMLS:C1959632 {source="MONDO:equivalentTo", source="Orphanet:98282"} +is_a: MONDO:0004949 {source="DOID:6536", source="EFO:0000200", source="NCIT:C4665"} ! neoplasm of mature B-cells +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000786 ! plasma cell +relationship: disease_arises_from_structure CL:0000786 {source="NCIT:C4665"} ! plasma cell +property_value: exactMatch DOID:6536 +property_value: exactMatch http://identifiers.org/mesh/D054219 +property_value: exactMatch http://identifiers.org/snomedct/415111003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1959632 +property_value: exactMatch NCIT:C4665 +property_value: exactMatch Orphanet:98282 + +[Term] +id: MONDO:0004965 +name: acinar cell carcinoma +def: "A carcinoma that arises from epithelial cells of the acinar cell" [https://orcid.org/0000-0002-6601-2165] +synonym: "ACCC" RELATED ABBREVIATION [ONCOTREE:ACCC] +synonym: "acinar adenocarcinoma" EXACT [NCIT:C3768] +synonym: "acinar carcinoma" EXACT [NCIT:C3768] +synonym: "acinar cell adenocarcinoma" EXACT [NCIT:C3768] +synonym: "acinar cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C3768] +synonym: "acinar cell carcinoma (morphologic abnormality)" EXACT [DOID:3025] +synonym: "acinic cell adenocarcinoma" EXACT [NCIT:C3768] +synonym: "acinic cell carcinoma" EXACT [DOID:3025, NCIT:C3768] +synonym: "acinic cell tumor" RELATED [GARD:0008568] +synonym: "carcinoma of acinar cell" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, acinar cell, malignant" EXACT [NCIT:C3768] +xref: DOID:3025 {source="MONDO:equivalentTo", source="EFO:0000216"} +xref: EFO:0000216 {source="MONDO:equivalentTo"} +xref: GARD:0008568 {source="MONDO:equivalentTo"} +xref: ICDO:8550/3 {source="NCIT:C3768"} +xref: MESH:D018267 {source="DOID:3025", source="MONDO:equivalentTo", source="EFO:0000216"} +xref: NCIT:C3768 {source="DOID:3025", source="MONDO:equivalentTo", source="EFO:0000216"} +xref: ONCOTREE:ACCC {source="MONDO:equivalentTo"} +xref: UMLS:C0206685 {source="DOID:3025", source="MONDO:equivalentTo", source="NCIT:C3768"} +is_a: MONDO:0004970 {source="MESH:D018267", source="NCIT:C3768"} ! adenocarcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0000622 ! acinar cell +relationship: disease_has_location CL:0000622 ! acinar cell +property_value: exactMatch DOID:3025 +property_value: exactMatch http://identifiers.org/mesh/D018267 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206685 +property_value: exactMatch NCIT:C3768 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004966 +name: gastritis +def: "Inflammation of the stomach." [NCIT:C26780] +synonym: "acute gastric mucosal erosion" EXACT [DOID:4029] +synonym: "erosive gastritis" EXACT [DOID:4029] +synonym: "erosive gastropathy" EXACT [DOID:4029] +synonym: "gastritis" EXACT [MONDO:ambiguous, NCIT:C26780] +synonym: "gastritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "inflammation of stomach" EXACT [] +synonym: "stomach inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:4029 {source="MONDO:equivalentTo", source="EFO:0000217"} +xref: EFO:0000217 {source="MONDO:equivalentTo"} +xref: HP:0005263 {source="MONDO:otherHierarchy"} +xref: ICD9:535.0 {source="EFO:0000217"} +xref: ICD9:535.00 {source="EFO:0000217"} +xref: ICD9:535.01 {source="EFO:0000217"} +xref: ICD9:535.4 {source="EFO:0000217"} +xref: ICD9:535.40 {source="MONDO:relatedTo", source="MONDO:i2s", source="EFO:0000217"} +xref: ICD9:535.41 {source="EFO:0000217"} +xref: MESH:D005756 {source="MONDO:equivalentTo", source="DOID:4029", source="EFO:0000217"} +xref: NCIT:C26780 {source="MONDO:equivalentTo", source="DOID:4029", source="EFO:0000217"} +xref: SCTID:4556007 {source="MONDO:equivalentTo", source="DOID:4029", source="EFO:0000217"} +xref: UMLS:C0017152 {source="NCIT:C26780", source="MONDO:equivalentTo", source="DOID:4029"} +xref: UMLS:C0267112 {source="MONDO:equivalentTo"} +xref: UMLS:C2243088 {source="MONDO:equivalentTo"} +xref: UMLS:C2243090 {source="MONDO:equivalentTo"} +xref: UMLS:C3854048 {source="MONDO:equivalentTo"} +is_a: MONDO:0004298 {source="DOID:4029", source="MESH:D005756", source="MONDO:Redundant", source="NCIT:C26780/inferred"} ! stomach disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000945 ! stomach +relationship: disease_has_inflammation_site UBERON:0000945 ! stomach +property_value: exactMatch DOID:4029 +property_value: exactMatch http://identifiers.org/mesh/D005756 +property_value: exactMatch http://identifiers.org/snomedct/4556007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017152 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267112 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2243088 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2243090 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3854048 +property_value: exactMatch NCIT:C26780 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "gastritis (disease)" xsd:string + +[Term] +id: MONDO:0004970 +name: adenocarcinoma +def: "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma." [NCIT:C2852] +synonym: "adenocarcinoma" EXACT [NCIT:C2852] +synonym: "adenocarcinoma NOS (morphologic abnormality)" EXACT [DOID:299] +synonym: "adenocarcinoma, malignant" EXACT [NCIT:C2852] +synonym: "adenocarcinoma, no subtype (morphologic abnormality)" EXACT [DOID:299] +synonym: "adenocarcinomas" EXACT [DOID:299] +synonym: "ADNOS" RELATED ABBREVIATION [ONCOTREE:ADNOS] +xref: CSP:2000-0386 {source="DOID:299"} +xref: DOID:299 {source="MONDO:equivalentTo", source="EFO:0000228"} +xref: EFO:0000228 {source="MONDO:equivalentTo"} +xref: ICDO:8140/3 {source="NCIT:C2852"} +xref: MESH:D000230 {source="MONDO:equivalentTo", source="EFO:0000228", source="DOID:299"} +xref: NCIT:C2852 {source="MONDO:equivalentTo", source="EFO:0000228", source="MONDO:exact-label-match", source="DOID:299"} +xref: ONCOTREE:ADNOS {source="MONDO:equivalentTo"} +xref: SCTID:443961001 {source="MONDO:equivalentTo", source="DOID:299"} +xref: UMLS:C0001418 {source="MONDO:equivalentTo", source="NCIT:C2852", source="DOID:299"} +is_a: MONDO:0004993 {source="DOID:299", source="EFO:0000228", source="MESH:D000230", source="NCIT:C2852"} ! carcinoma +is_a: MONDO:0024276 {source="NCIT:C2852"} ! glandular cell neoplasm +property_value: exactMatch DOID:299 +property_value: exactMatch http://identifiers.org/mesh/D000230 +property_value: exactMatch http://identifiers.org/snomedct/443961001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001418 +property_value: exactMatch NCIT:C2852 + +[Term] +id: MONDO:0004975 +name: Alzheimer disease +def: "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language." [NCIT:P378] +synonym: "AD" EXACT ABBREVIATION [DOID:10652] +synonym: "Alzheimer dementia" EXACT [NCIT:C2866] +synonym: "Alzheimer disease" EXACT [DOID:10652, NCIT:C2866] +synonym: "Alzheimer disease, familial" NARROW [DOID:10652, MESH:C536597] +synonym: "Alzheimer's dementia" EXACT [NCIT:C2866] +synonym: "Alzheimer's disease" EXACT [ISBN-13:978-1-259-64403-0, NCIT:C2866] +synonym: "Alzheimers dementia" EXACT [DOID:10652, NCIT:C2866] +synonym: "Alzheimers disease" EXACT [DOID:10652] +synonym: "presenile and senile dementia" EXACT [OMIM:104300] +xref: DOID:10652 {source="MONDO:equivalentTo", source="EFO:0000249"} +xref: EFO:0000249 {source="MONDO:equivalentTo", source="DOID:10652"} +xref: GARD:0000632 +xref: HP:0002511 {source="MONDO:otherHierarchy"} +xref: ICD10CM:G30 {source="MONDO:equivalentTo", source="DOID:10652"} +xref: ICD9:290.1 {source="EFO:0000249"} +xref: ICD9:331.0 {source="EFO:0000249", source="DOID:10652"} +xref: KEGG:05010 {source="MONDO:relatedTo", source="DOID:10652"} +xref: MESH:D000544 {source="MONDO:equivalentTo", source="EFO:0000249", source="DOID:10652"} +xref: NCIT:C2866 {source="MONDO:equivalentTo", source="EFO:0000249", source="DOID:10652"} +xref: NCIT:C38778 {source="MONDO:otherHierarchy", source="EFO:0000249"} +xref: NIFSTD:birnlex_2092 {source="EFO:0000249"} +xref: OMIM:104300 {source="MONDO:equivalentTo", source="EFO:0000249", source="DOID:10652"} +xref: Orphanet:238616 {source="MONDO:equivalentTo"} +xref: SCTID:142811000119104 {source="MONDO:equivalentTo"} +xref: UMLS:C0002395 {source="MONDO:cjm", source="MONDO:equivalentTo", source="MONDO:notFoundInDiseaseSubset", source="DOID:10652", source="NCIT:C2866"} +is_a: MONDO:0001627 {source="MESH:D000544", source="NCIT:C2866"} ! dementia +is_a: MONDO:0005574 {source="DOID:10652", source="MESH:D000544"} ! tauopathy +property_value: exactMatch DOID:10652 +property_value: exactMatch http://identifiers.org/mesh/D000544 +property_value: exactMatch http://identifiers.org/snomedct/142811000119104 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0002395 +property_value: exactMatch https://icd.codes/icd10cm/G30 +property_value: exactMatch https://omim.org/entry/104300 +property_value: exactMatch NCIT:C2866 +property_value: exactMatch Orphanet:238616 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: relatedMatch NCIT:C38778 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4013 xsd:string + +[Term] +id: MONDO:0004976 +name: amyotrophic lateral sclerosis +def: "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord." [Orphanet:803] +subset: ordo_disease {source="Orphanet:803"} +synonym: "ALS" EXACT ABBREVIATION [DOID:332, NCIT:C34373, Orphanet:803] +synonym: "amyotrophic lateral sclerosis" EXACT [] +synonym: "Charcot disease" EXACT [Orphanet:803] +synonym: "Lou Gehrig disease" EXACT [Orphanet:803] +synonym: "Lou Gehrig's disease" EXACT [DOID:332] +synonym: "motor neuron disease, bulbar" EXACT [DOID:332] +xref: DOID:332 {source="EFO:0000253", source="MONDO:equivalentTo"} +xref: EFO:0000253 {source="MONDO:equivalentTo", source="DOID:332"} +xref: GARD:0005786 {source="MONDO:equivalentTo"} +xref: ICD10CM:G12.2 {source="Orphanet:803", source="Orphanet:803/ntbt"} +xref: ICD10CM:G12.21 {source="MONDO:equivalentTo", source="DOID:332"} +xref: ICD9:335.20 {source="EFO:0000253", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:332"} +xref: KEGG:05014 {source="MONDO:relatedTo", source="DOID:332"} +xref: MedDRA:10002026 {source="Orphanet:803", source="Orphanet:803/e"} +xref: MESH:D000690 {source="EFO:0000253", source="MONDO:equivalentTo", source="Orphanet:803", source="DOID:332", source="Orphanet:803/e"} +xref: NCIT:C34373 {source="EFO:0000253", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:332"} +xref: NIFSTD:birnlex_12566 {source="EFO:0000253"} +xref: Orphanet:803 {source="MONDO:equivalentTo", source="DOID:332"} +xref: SCTID:86044005 {source="EFO:0000253", source="MONDO:equivalentTo", source="DOID:332"} +xref: UMLS:C0002736 {source="NCIT:C34373", source="MONDO:equivalentTo", source="Orphanet:803", source="DOID:332", source="Orphanet:803/e"} +is_a: MONDO:0003182 {source="Wikipedia:Anterior_horn_disease"} ! anterior horn disorder +is_a: MONDO:0020128 {source="DOID:332", source="ICD10CM:G12.21", source="MESH:D000690", source="MONDO:Redundant", source="Orphanet:803"} ! motor neuron disorder +relationship: disease_has_feature HP:0007354 ! Amyotrophic lateral sclerosis +relationship: has_modifier MONDO:0021136 {source="MONDO:0015918"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10002026 +property_value: exactMatch DOID:332 +property_value: exactMatch http://identifiers.org/mesh/D000690 +property_value: exactMatch http://identifiers.org/snomedct/86044005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0002736 +property_value: exactMatch https://icd.codes/icd10cm/G12.21 +property_value: exactMatch NCIT:C34373 +property_value: exactMatch Orphanet:803 + +[Term] +id: MONDO:0004979 +name: asthma +def: "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety." [EFO:0000270] +synonym: "bronchial hyperreactivity" EXACT [DOID:2841] +synonym: "chronic obstructive asthma" EXACT [DOID:2841] +synonym: "chronic obstructive asthma with acute exacerbation" NARROW [DOID:2841] +synonym: "chronic obstructive asthma with status asthmaticus" EXACT [DOID:2841] +synonym: "exercise induced asthma" NARROW [DOID:2841] +synonym: "exercise-induced asthma" NARROW [DOID:2841] +xref: DOID:2841 {source="MONDO:equivalentTo", source="EFO:0000270"} +xref: EFO:0000270 {source="MONDO:equivalentTo", source="DOID:2841"} +xref: GARD:0010246 {source="MONDO:equivalentTo"} +xref: HP:0002099 {source="MONDO:otherHierarchy"} +xref: ICD10CM:J45 {source="MONDO:equivalentTo", source="DOID:2841"} +xref: ICD9:493 {source="DOID:2841", source="EFO:0000270"} +xref: ICD9:493.81 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:493.9 {source="DOID:2841"} +xref: KEGG:05310 {source="MONDO:relatedTo", source="DOID:2841"} +xref: MESH:D001249 {source="MONDO:equivalentTo", source="DOID:2841", source="EFO:0000270"} +xref: NCIT:C28397 {source="MONDO:equivalentTo", source="DOID:2841", source="EFO:0000270"} +xref: SCTID:31387002 {source="MONDO:equivalentTo"} +xref: UMLS:C0004096 {source="NCIT:C28397", source="MONDO:equivalentTo", source="DOID:2841"} +is_a: MONDO:0001358 {source="DOID:2841", source="EFO:0000270", source="MESH:D001249"} ! bronchial disorder +property_value: exactMatch DOID:2841 +property_value: exactMatch http://identifiers.org/mesh/D001249 +property_value: exactMatch http://identifiers.org/snomedct/31387002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004096 +property_value: exactMatch https://icd.codes/icd10cm/J45 +property_value: exactMatch NCIT:C28397 + +[Term] +id: MONDO:0004980 +name: atopic eczema +def: "A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema." [MESH:D003876] +synonym: "allergic" EXACT [DOID:3310] +synonym: "allergic dermatitis" EXACT [DOID:3310] +synonym: "allergic form of dermatitis" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "Atopic dermatitis" EXACT [DOID:3310] +synonym: "atopic eczema" EXACT [DOID:3310] +synonym: "Atopic neurodermatitis" EXACT [DOID:3310] +synonym: "Besnier's prurigo" EXACT [DOID:3310] +synonym: "eczema" EXACT [NCIT:C3001] +synonym: "eczematous dermatitis" EXACT [NCIT:C3001] +xref: DOID:3310 {source="EFO:0000274", source="MONDO:equivalentTo"} +xref: EFO:0000274 {source="DOID:3310", source="MONDO:equivalentTo"} +xref: ICD9:691 {source="EFO:0000274"} +xref: ICD9:691.8 {source="EFO:0000274"} +xref: NCIT:C3001 {source="MONDO:equivalentTo"} +xref: OMIMPS:603165 {source="DOID:3310", source="MONDO:equivalentTo"} +is_a: MONDO:0002406 {source="DOID:3310", source="EFO:0000274", source="MONDO:Redundant", source="NCIT:C3001"} ! dermatitis +is_a: MONDO:0005271 {source="EFO:0000274", source="MONDO:Redundant"} ! allergic disease +is_a: MONDO:0024255 ! genetic skin disease +intersection_of: MONDO:0002406 ! dermatitis +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +relationship: disease_has_feature HP:0000964 ! Eczema +property_value: exactMatch DOID:3310 +property_value: exactMatch https://omim.org/phenotypicSeries/PS603165 +property_value: exactMatch NCIT:C3001 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0004982 +name: pancreatitis +def: "Inflammation of the pancreas." [NCIT:C3306] +synonym: "inflammation of pancreas" EXACT [] +synonym: "pancreas inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:4989 {source="MONDO:equivalentTo", source="EFO:0000278"} +xref: EFO:0000278 {source="MONDO:equivalentTo", source="DOID:4989"} +xref: MESH:D010195 {source="MONDO:equivalentTo", source="EFO:0000278", source="DOID:4989"} +xref: NCIT:C3306 {source="MONDO:equivalentTo", source="EFO:0000278", source="DOID:4989", source="MONDO:exact-label-match"} +xref: SCTID:75694006 {source="MONDO:equivalentTo", source="EFO:0000278", source="DOID:4989"} +xref: UMLS:C0030305 {source="MONDO:equivalentTo", source="DOID:4989", source="NCIT:C3306"} +is_a: MONDO:0002356 {source="DOID:4989", source="MESH:D010195", source="MONDO:Redundant", source="NCIT:C3306/inferred"} ! pancreas disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001264 ! pancreas +relationship: disease_has_inflammation_site UBERON:0001264 ! pancreas +property_value: exactMatch DOID:4989 +property_value: exactMatch http://identifiers.org/mesh/D010195 +property_value: exactMatch http://identifiers.org/snomedct/75694006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030305 +property_value: exactMatch NCIT:C3306 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0004985 +name: bipolar disorder +def: "A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression." [NCIT:C34423] +synonym: "bipolar affective disorder" RELATED [] +synonym: "bipolar depression" NARROW [DOID:3312] +synonym: "bipolar disorder" EXACT [NCIT:C34423] +synonym: "bipolar disorder manic phase" NARROW [DOID:3312] +synonym: "depressive-manic psych." RELATED [DOID:3312] +synonym: "MAFD" RELATED ABBREVIATION [] +synonym: "major affective disorder" EXACT [MONDO:0000055] +synonym: "major bipolar affective disorder" RELATED [] +synonym: "manic bipolar affective disorder" NARROW [DOID:3312, NCIT:C34805] +synonym: "manic bipolar I disorder" NARROW [DOID:3312] +synonym: "manic depression" NARROW [DOID:3312] +synonym: "manic depressive disorder" NARROW [DOID:3312, NCIT:C34423] +synonym: "manic disorder" NARROW [DOID:3312] +synonym: "manic-depression" EXACT [NCIT:C34423] +synonym: "manic-depressive illness" RELATED [] +synonym: "manic-depressive psychosis" RELATED [] +synonym: "mixed bipolar disorder" NARROW [DOID:3312] +xref: DOID:3312 {source="MONDO:equivalentTo", source="EFO:0000289"} +xref: EFO:0000289 {source="DOID:3312", source="MONDO:equivalentTo"} +xref: ICD10CM:F31 {source="DOID:3312", source="MONDO:equivalentTo"} +xref: ICD10WHO:F31 {source="MONDO:equivalentTo"} +xref: ICD9:296.40 {source="DOID:3312"} +xref: ICD9:296.60 {source="DOID:3312"} +xref: ICD9:296.80 {source="DOID:3312", source="MONDO:equivalentTo", source="EFO:0000289", source="MONDO:i2s"} +xref: ICD9:296.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001714 {source="DOID:3312", source="MONDO:equivalentTo", source="EFO:0000289"} +xref: NCIT:C34423 {source="DOID:3312", source="MONDO:equivalentTo", source="EFO:0000289"} +xref: NIFSTD:birnlex_12754 {source="EFO:0000289"} +xref: SCTID:13746004 {source="DOID:3312", source="MONDO:equivalentTo", source="EFO:0000289"} +xref: UMLS:C0005586 {source="DOID:3312", source="MONDO:equivalentTo", source="NCIT:C34423"} +is_a: MONDO:0005371 {source="DOID:3312", source="EFO:0000289", source="ICD10CM:F31", source="NCIT:C34423", source="NCIT:C34805/inferred"} ! mood disorder +relationship: disease_has_feature MONDO:0004617 {source="MONDO:Wikidata"} ! recurrent hypersomnia +property_value: exactMatch DOID:3312 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/F31 +property_value: exactMatch http://identifiers.org/mesh/D001714 +property_value: exactMatch http://identifiers.org/snomedct/13746004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005586 +property_value: exactMatch https://icd.codes/icd10cm/F31 +property_value: exactMatch NCIT:C34423 + +[Term] +id: MONDO:0004986 +name: urinary bladder carcinoma +def: "A carcinoma that arises from epithelial cells of the urinary bladder" [https://orcid.org/0000-0002-6601-2165] +synonym: "bladder cancer" BROAD [NCIT:C4912] +synonym: "bladder carcinoma" EXACT [MONDO:ambiguous, NCIT:C4912] +synonym: "cancer of bladder" BROAD [NCIT:C4912] +synonym: "cancer of the bladder" BROAD [NCIT:C4912] +synonym: "cancer of the urinary bladder" BROAD [NCIT:C4912] +synonym: "cancer of urinary bladder" BROAD [NCIT:C4912] +synonym: "carcinoma bladder" EXACT [DOID:4007] +synonym: "carcinoma of bladder" EXACT [DOID:4007, MTH:108, NCIT:C4912] +synonym: "carcinoma of the bladder" EXACT [NCIT:C4912] +synonym: "carcinoma of the urinary bladder" EXACT [NCIT:C4912] +synonym: "carcinoma of urinary bladder" EXACT [DOID:4007, MONDO:patterns/carcinoma, NCIT:C4912] +synonym: "urinary bladder cancer" BROAD [NCIT:C4912] +synonym: "urinary bladder carcinoma" EXACT [MONDO:patterns/location, NCIT:C4912] +xref: DOID:4007 {source="MONDO:equivalentTo", source="EFO:0000292"} +xref: EFO:0000292 {source="MONDO:equivalentTo", source="DOID:4007"} +xref: HP:0002862 {source="MONDO:otherHierarchy"} +xref: NCIT:C4912 {source="MONDO:equivalentTo", source="DOID:4007", source="EFO:0000292"} +xref: SCTID:255108000 {source="MONDO:equivalentTo", source="DOID:4007", source="EFO:0000292"} +xref: UMLS:C0699885 {source="MONDO:equivalentTo", source="DOID:4007", source="NCIT:C4912"} +is_a: MONDO:0001187 {source="DOID:4007", source="MONDO:Redundant", source="NCIT:C4912"} ! urinary bladder cancer +is_a: MONDO:0004993 {source="DOID:4007", source="EFO:0000292", source="MONDO:Redundant", source="NCIT:C4912"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:4007 +property_value: exactMatch http://identifiers.org/snomedct/255108000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0699885 +property_value: exactMatch NCIT:C4912 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004987 +name: urinary bladder neoplasm +def: "A benign or malignant, primary or metastatic neoplasm of the bladder. - 2003" [NCIT:C2901] +synonym: "bladder neoplasm" EXACT [https://orcid.org/0000-0002-6601-2165, NCIT:C2901] +synonym: "bladder tumor" EXACT [NCIT:C2901] +synonym: "bladder tumors" EXACT [NCIT:C2901] +synonym: "neoplasm of bladder" EXACT [NCIT:C2901] +synonym: "neoplasm of the bladder" EXACT [NCIT:C2901] +synonym: "neoplasm of the urinary bladder" EXACT [NCIT:C2901] +synonym: "neoplasm of urinary bladder" EXACT [MONDO:patterns/neoplasm, NCIT:C2901] +synonym: "tumor of bladder" EXACT [NCIT:C2901] +synonym: "tumor of the bladder" EXACT [NCIT:C2901] +synonym: "tumor of the urinary bladder" EXACT [NCIT:C2901] +synonym: "tumor of urinary bladder" EXACT [MONDO:patterns/neoplasm, NCIT:C2901] +synonym: "urinary bladder neoplasm" EXACT [NCIT:C2901] +synonym: "urinary bladder neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "urinary bladder neoplasms" EXACT [NCIT:C2901] +synonym: "urinary bladder tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2901] +synonym: "urinary bladder tumors" EXACT [NCIT:C2901] +xref: EFO:0000294 {source="MONDO:equivalentTo"} +xref: ICD9:239.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C2901 {source="EFO:0000294", source="MONDO:equivalentTo"} +xref: SCTID:126885006 {source="EFO:0000294", source="MONDO:equivalentTo"} +xref: UMLS:C0005695 {source="NCIT:C2901", source="MONDO:equivalentTo"} +is_a: MONDO:0006026 {source="MONDO:Redundant", source="NCIT:C2901"} ! urinary bladder disorder +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C2901"} ! urinary system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch http://identifiers.org/snomedct/126885006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005695 +property_value: exactMatch NCIT:C2901 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0004988 +name: breast adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the breast" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of breast" EXACT [DOID:3458, NCIT:C5214] +synonym: "adenocarcinoma of the breast" EXACT [NCIT:C5214] +synonym: "breast adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C5214] +synonym: "mammary adenocarcinoma" EXACT [DOID:3458, NCIT:C5214] +xref: DOID:3458 {source="MONDO:equivalentTo", source="EFO:0000304"} +xref: EFO:0000304 {source="MONDO:equivalentTo"} +xref: NCIT:C5214 {source="DOID:3458", source="MONDO:equivalentTo", source="EFO:0000304", source="MONDO:exact-label-match"} +is_a: MONDO:0000653 ! integumentary system cancer +is_a: MONDO:0004970 {source="DOID:3458", source="EFO:0000304", source="MONDO:Redundant", source="NCIT:C5214"} ! adenocarcinoma +is_a: MONDO:0004989 {source="DOID:3458", source="EFO:0000304", source="MONDO:Redundant", source="NCIT:C5214"} ! breast carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000310 ! breast +relationship: disease_has_location UBERON:0001911 {source="EFO:0000784"} ! mammary gland +property_value: exactMatch DOID:3458 +property_value: exactMatch NCIT:C5214 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0004989 +name: breast carcinoma +def: "A carcinoma that arises from epithelial cells of the breast" [https://orcid.org/0000-0002-6601-2165] +synonym: "breast cancer" BROAD [NCIT:C4872] +synonym: "breast cancer, NOS" BROAD [NCIT:C4872] +synonym: "breast carcinoma" EXACT [MONDO:patterns/location, NCIT:C4872] +synonym: "cancer of breast" BROAD [NCIT:C4872] +synonym: "cancer of the breast" BROAD [NCIT:C4872] +synonym: "cancer, breast" BROAD [NCIT:C4872] +synonym: "carcinoma of breast" EXACT [DOID:3459, MONDO:patterns/carcinoma, NCIT:C4872] +synonym: "carcinoma of the breast" EXACT [NCIT:C4872] +synonym: "mammary carcinoma" EXACT [DOID:3459, NCIT:C4872] +xref: DOID:3459 {source="MONDO:equivalentTo", source="EFO:0000305"} +xref: EFO:0000305 {source="MONDO:equivalentTo", source="DOID:3459"} +xref: NCIT:C4872 {source="MONDO:equivalentTo", source="DOID:3459", source="EFO:0000305"} +xref: SCTID:254838004 {source="MONDO:equivalentTo", source="DOID:3459", source="EFO:0000305"} +xref: UMLS:C0678222 {source="MONDO:equivalentTo", source="NCIT:C4872", source="DOID:3459"} +is_a: MONDO:0004993 {source="DOID:3459", source="EFO:0000305", source="MONDO:Redundant", source="NCIT:C4872"} ! carcinoma +is_a: MONDO:0007254 {source="DOID:3459", source="MONDO:Redundant", source="NCIT:C4872"} ! breast cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:3459 +property_value: exactMatch http://identifiers.org/snomedct/254838004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0678222 +property_value: exactMatch NCIT:C4872 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0004992 +name: cancer +def: "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." [NCIT:C9305] +synonym: "CA" EXACT ABBREVIATION [NCIT:C9305] +synonym: "cancer" EXACT [NCIT:C9305] +synonym: "cell type cancer" EXACT [MONDO:0000404] +synonym: "malignancy" EXACT [NCIT:C9305] +synonym: "malignant Growth" EXACT [NCIT:C9305] +synonym: "malignant neoplasm" EXACT [DOID:162, NCIT:C9305] +synonym: "malignant neoplasm (disease)" EXACT [] +synonym: "malignant neoplastic disease" EXACT [NCIT:C9305] +synonym: "malignant tumor" EXACT [DOID:162, NCIT:C9305] +synonym: "MT" RELATED ABBREVIATION [ONCOTREE:MT] +synonym: "neoplasm (disease), malignant" EXACT [MONDO:patterns/malignant] +synonym: "neoplasm, malignant" EXACT [NCIT:C9305] +synonym: "organ system cancer" EXACT [MONDO:0000403] +synonym: "primary cancer" EXACT [DOID:162] +xref: DOID:0050686 {source="MONDO:equivalentTo"} +xref: DOID:0050687 {source="MONDO:equivalentTo"} +xref: DOID:162 {source="MONDO:equivalentTo", source="EFO:0000311"} +xref: EFO:0000311 {source="MONDO:equivalentTo"} +xref: GARD:0011960 {source="MONDO:equivalentTo"} +xref: ICD9:195.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:199 {source="DOID:162"} +xref: ICD9:199.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8000/3 {source="NCIT:C9305"} +xref: NCIT:C9305 {source="MONDO:equivalentTo", source="EFO:0000311", source="DOID:162"} +xref: NIFSTD:birnlex_406 {source="EFO:0000311"} +xref: ONCOTREE:MT {source="MONDO:equivalentTo"} +xref: SCTID:363346000 {source="MONDO:equivalentTo", source="DOID:162"} +xref: UMLS:C0006826 {source="MONDO:equivalentTo", source="NCIT:C9305", source="DOID:162"} +is_a: MONDO:0005070 {source="DOID:0050686/inferred", source="DOID:0050687/inferred", source="DOID:162", source="EFO:0000311", source="MONDO:Redundant", source="NCIT:C9305/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +disjoint_from: MONDO:0005165 ! benign neoplasm +relationship: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch DOID:0050686 +property_value: exactMatch DOID:0050687 +property_value: exactMatch DOID:162 +property_value: exactMatch http://identifiers.org/snomedct/363346000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006826 +property_value: exactMatch NCIT:C9305 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0004993 +name: carcinoma +def: "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." [NCIT:C2916] +synonym: "carcinoma" EXACT [NCIT:C2916] +synonym: "carcinoma, malignant" EXACT [NCIT:C2916] +synonym: "epithelial carcinoma" EXACT [NCIT:C2916] +synonym: "epithelioma" BROAD [DOID:305] +synonym: "epithelioma malignant" EXACT [NCIT:C2916] +synonym: "malignant epithelial neoplasm" EXACT [NCIT:C2916] +synonym: "malignant epithelial tumor" EXACT [NCIT:C2916] +synonym: "malignant epithelioma" EXACT [DOID:305, NCIT:C2916, NCIT:C6927] +synonym: "Other carcinoma" EXACT [NCIT:C2916] +xref: CSP:2000-1867 {source="DOID:305"} +xref: DOID:305 {source="MONDO:equivalentTo", source="EFO:0000313"} +xref: EFO:0000313 {source="MONDO:equivalentTo"} +xref: ICDO:8010/3 {source="NCIT:C2916"} +xref: ICDO:8011/3 {source="NCIT:C2916"} +xref: MESH:D002277 {source="DOID:305", source="MONDO:equivalentTo", source="EFO:0000313"} +xref: NCIT:C2916 {source="DOID:305", source="MONDO:equivalentTo", source="EFO:0000313"} +xref: SCTID:722688002 {source="MONDO:equivalentTo"} +xref: UMLS:C0007097 {source="DOID:305", source="NCIT:C2916", source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:305", source="DOID:305/inferred", source="EFO:0000313", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0005626 {source="MESH:D002277", source="MONDO:Redundant", source="NCIT:C2916"} ! epithelial neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_arises_from_structure CL:0000066 ! epithelial cell +relationship: disease_has_location CL:0000066 {source="EFO:0000784"} ! epithelial cell +property_value: exactMatch DOID:305 +property_value: exactMatch http://identifiers.org/mesh/D002277 +property_value: exactMatch http://identifiers.org/snomedct/722688002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007097 +property_value: exactMatch NCIT:C2916 + +[Term] +id: MONDO:0004994 +name: cardiomyopathy +def: "A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive." [NCIT:C34830] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:167848"} +synonym: "Cardiomyopathies" EXACT [DOID:0050700, MESH:D009202] +synonym: "cardiomyopathy" EXACT [MONDO:0015670] +xref: DOID:0050700 {source="MONDO:equivalentTo", source="EFO:0000318"} +xref: EFO:0000318 {source="MONDO:equivalentTo"} +xref: GARD:0011958 {source="MONDO:equivalentTo"} +xref: ICD10CM:I42 {source="DOID:0050700", source="MONDO:equivalentTo"} +xref: ICD9:425 {source="DOID:0050700", source="EFO:0000318"} +xref: ICD9:425.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:425.9 {source="DOID:0050700"} +xref: MedDRA:10007636 {source="Orphanet:167848/e", source="Orphanet:167848"} +xref: MESH:D009202 {source="Orphanet:167848/e", source="DOID:0050700", source="MONDO:equivalentTo", source="EFO:0000318", source="Orphanet:167848"} +xref: NCIT:C34830 {source="DOID:0050700", source="MONDO:equivalentTo", source="EFO:0000318"} +xref: Orphanet:167848 {source="MONDO:equivalentTo"} +xref: SCTID:85898001 {source="DOID:0050700", source="MONDO:equivalentTo", source="EFO:0000318"} +xref: UMLS:C0878544 {source="Orphanet:167848/e", source="DOID:0050700", source="MONDO:equivalentTo", source="NCIT:C34830", source="Orphanet:167848"} +is_a: MONDO:0003939 ! muscle tissue disorder +is_a: MONDO:0005267 {source="Orphanet:167848"} ! heart disorder +relationship: disease_has_location UBERON:0001133 ! cardiac muscle tissue +relationship: has_modifier MONDO:0021136 {source="MONDO:0019996"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10007636 +property_value: exactMatch DOID:0050700 +property_value: exactMatch http://identifiers.org/mesh/D009202 +property_value: exactMatch http://identifiers.org/snomedct/85898001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0878544 +property_value: exactMatch https://icd.codes/icd10cm/I42 +property_value: exactMatch NCIT:C34830 +property_value: exactMatch Orphanet:167848 + +[Term] +id: MONDO:0004995 +name: cardiovascular disorder +def: "A disease involving the cardiovascular system." [https://orcid.org/0000-0002-6601-2165] +synonym: "cardiovascular disease" EXACT [DOID:1287, NCIT:C2931] +synonym: "cardiovascular disease (CVD)" EXACT [NCIT:C2931] +synonym: "cardiovascular disorder" EXACT [NCIT:C2931] +synonym: "cardiovascular system disease" EXACT [MONDO:patterns/location] +synonym: "cardiovascular system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "circulatory system disease" RELATED [MONDO:cjm] +synonym: "disease of cardiovascular system" EXACT [MONDO:patterns/location_top] +synonym: "disease of subdivision of hemolymphoid system" EXACT [DOID:1287] +synonym: "disease or disorder of cardiovascular system" EXACT [] +synonym: "disorder of cardiovascular system" EXACT [MONDO:patterns/location_top, NCIT:C2931] +xref: DOID:1287 {source="MONDO:equivalentTo", source="EFO:0000319"} +xref: EFO:0000319 {source="MONDO:equivalentTo"} +xref: ICD9:390-459.99 {source="EFO:0000319"} +xref: ICD9:420-429.99 {source="EFO:0000319"} +xref: ICD9:423 {source="EFO:0000319"} +xref: ICD9:423.8 {source="EFO:0000319"} +xref: ICD9:424 {source="EFO:0000319"} +xref: ICD9:429 {source="EFO:0000319"} +xref: ICD9:429.2 {source="DOID:1287", source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0000319"} +xref: ICD9:429.7 {source="EFO:0000319"} +xref: ICD9:429.8 {source="EFO:0000319"} +xref: ICD9:429.81 {source="EFO:0000319"} +xref: ICD9:429.89 {source="EFO:0000319"} +xref: ICD9:459.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:459.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0000319"} +xref: MESH:D002318 {source="DOID:1287", source="MONDO:equivalentTo", source="EFO:0000319"} +xref: NCIT:C2931 {source="DOID:1287", source="MONDO:equivalentTo", source="EFO:0000319"} +xref: SCTID:49601007 {source="DOID:1287", source="MONDO:equivalentTo", source="EFO:0000319"} +xref: UMLS:C0007222 {source="DOID:1287", source="MONDO:equivalentTo", source="NCIT:C2931"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0004535 ! cardiovascular system +relationship: disease_has_location UBERON:0004535 ! cardiovascular system +property_value: exactMatch DOID:1287 +property_value: exactMatch http://identifiers.org/mesh/D002318 +property_value: exactMatch http://identifiers.org/snomedct/49601007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007222 +property_value: exactMatch NCIT:C2931 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005001 +name: chronic gastritis +def: "Inflammation of the stomach that is chronic in nature." [NCIT:P378] +synonym: "chronic gastritis" EXACT [MONDO:ambiguous] +synonym: "chronic gastritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "gastritis (disease), chronic" EXACT [MONDO:patterns/chronic] +xref: EFO:0000337 {source="MONDO:equivalentTo"} +xref: HP:0005231 {source="MONDO:otherHierarchy"} +xref: ICD9:535.4 {source="EFO:0000337"} +xref: ICD9:535.40 {source="EFO:0000337"} +xref: ICD9:535.41 {source="EFO:0000337"} +xref: NCIT:C26929 {source="MONDO:equivalentTo", source="EFO:0000337"} +xref: SCTID:8493009 {source="MONDO:equivalentTo", source="EFO:0000337"} +xref: UMLS:C0085695 {source="NCIT:C26929", source="MONDO:equivalentTo"} +is_a: MONDO:0004966 {source="EFO:0000337", source="MONDO:Redundant", source="NCIT:C26929"} ! gastritis +intersection_of: MONDO:0004966 ! gastritis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/8493009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085695 +property_value: exactMatch NCIT:C26929 +property_value: IAO:0000589 "chronic gastritis (disease)" xsd:string + +[Term] +id: MONDO:0005002 +name: chronic obstructive pulmonary disease +def: "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." [NCIT:P378] +synonym: "chronic obstructive airway disease" EXACT [DOID:3083] +synonym: "chronic obstructive airways disease" EXACT [NCIT:C3199] +synonym: "chronic obstructive lung disease" EXACT [DOID:3083] +synonym: "chronic obstructive pulmonary disease (COPD)" EXACT [NCIT:C3199] +synonym: "chronic obstructive pulmonary disease, (COPD)" EXACT [NCIT:C3199] +synonym: "cold" EXACT [NCIT:C3199] +synonym: "cold (chronic obstructive lung disease)" EXACT [DOID:3083] +synonym: "COPD" EXACT ABBREVIATION [DOID:3083, NCIT:C3199] +synonym: "COPD, chronic obstructive pulmonary disease" EXACT [NCIT:C3199] +synonym: "disease (COPD), chronic obstructive" EXACT [NCIT:C3199] +synonym: "obstructive lung disease, chronic" EXACT [MONDO:patterns/chronic] +synonym: "obstructive pulmonary disease (COPD), chronic" EXACT [NCIT:C3199] +synonym: "pulmonary disease (COPD), chronic obstructive" EXACT [NCIT:C3199] +xref: DOID:3083 {source="EFO:0000341", source="MONDO:equivalentTo"} +xref: EFO:0000341 {source="MONDO:equivalentTo", source="DOID:3083"} +xref: ICD9:490-496.99 {source="EFO:0000341"} +xref: ICD9:496 {source="EFO:0000341", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D029424 {source="EFO:0000341", source="MONDO:equivalentTo", source="DOID:3083"} +xref: NCIT:C3199 {source="EFO:0000341", source="MONDO:equivalentTo", source="DOID:3083"} +xref: SCTID:13645005 {source="EFO:0000341", source="MONDO:equivalentTo", source="DOID:3083"} +is_a: MONDO:0002267 {source="DOID:3083", source="MESH:D029424", source="MONDO:Redundant"} ! obstructive lung disease +is_a: MONDO:0002567 ! tracheal disorder +intersection_of: MONDO:0002267 ! obstructive lung disease +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:3083 +property_value: exactMatch http://identifiers.org/mesh/D029424 +property_value: exactMatch http://identifiers.org/snomedct/13645005 +property_value: exactMatch NCIT:C3199 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0005003 +name: chronic pancreatitis +def: "A chronic inflammatory process causing damage and fibrosis of the pancreatic parenchyma. Signs and symptoms include abdominal pain, malabsorption and diabetes mellitus." [NCIT:P378] +synonym: "pancreatitis, chronic" EXACT [MONDO:patterns/chronic] +xref: EFO:0000342 {source="MONDO:equivalentTo"} +xref: ICD9:577.1 {source="EFO:0000342", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D050500 {source="EFO:0000342", source="MONDO:equivalentTo"} +xref: NCIT:C84637 {source="EFO:0000342", source="MONDO:equivalentTo"} +xref: SCTID:235494005 {source="EFO:0000342", source="MONDO:equivalentTo"} +xref: UMLS:C0149521 {source="NCIT:C84637", source="MONDO:equivalentTo"} +is_a: MONDO:0004982 {source="EFO:0000342", source="MESH:D050500", source="MONDO:Redundant", source="NCIT:C84637"} ! pancreatitis +intersection_of: MONDO:0004982 ! pancreatitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/mesh/D050500 +property_value: exactMatch http://identifiers.org/snomedct/235494005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149521 +property_value: exactMatch NCIT:C84637 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0005008 +name: colorectal adenocarcinoma +def: "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." [NCIT:C5105] +comment: Editor note: we follow NCIT in treating colorectal and large intestine as equivalent +synonym: "adenocarcinoma of large bowel" EXACT [NCIT:C5105] +synonym: "adenocarcinoma of large intestine" EXACT [NCIT:C5105] +synonym: "adenocarcinoma of the large bowel" EXACT [NCIT:C5105] +synonym: "adenocarcinoma of the large intestine" EXACT [NCIT:C5105] +synonym: "colorectal (colon or rectal) adenocarcinoma" EXACT [NCIT:C5105] +synonym: "colorectal adenocarcinoma" EXACT [NCIT:C5105] +synonym: "colorectum adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "large bowel adenocarcinoma" EXACT [NCIT:C5105] +synonym: "large intestine adenocarcinoma" EXACT [NCIT:C5105] +xref: DOID:0050861 {source="EFO:0000365", source="MONDO:equivalentTo"} +xref: DOID:0050913 {source="MONDO:equivalentTo"} +xref: EFO:0000365 {source="MONDO:equivalentTo"} +xref: NCIT:C5105 {source="EFO:0000365", source="MONDO:equivalentTo"} +xref: ONCOTREE:COADREAD {source="MONDO:equivalentTo"} +xref: SCTID:269533000 {source="EFO:0000365", source="MONDO:directSiblingOf"} +xref: SCTID:408645001 {source="MONDO:equivalentTo"} +xref: UMLS:C0699790 {source="MONDO:ncbi_mim2gene_medline", source="MONDO:directSiblingOf"} +xref: UMLS:C1319315 {source="MONDO:equivalentTo", source="NCIT:C5105"} +is_a: MONDO:0004970 {source="DOID:0050913", source="EFO:0000365", source="MONDO:Redundant", source="NCIT:C5105"} ! adenocarcinoma +is_a: MONDO:0024331 ! colorectal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0012652 ! colorectum +property_value: exactMatch DOID:0050861 +property_value: exactMatch DOID:0050913 +property_value: exactMatch http://identifiers.org/snomedct/408645001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1319315 +property_value: exactMatch NCIT:C5105 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005010 +name: coronary artery disorder +def: "Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC)" [NCIT:C26732] +synonym: "CAD" EXACT ABBREVIATION [NCIT:C26732] +synonym: "CHD" EXACT ABBREVIATION [DOID:3393] +synonym: "CHD (coronary heart disease)" EXACT [DOID:3393] +synonym: "coronary arteriosclerosis" NARROW [DOID:3393] +synonym: "coronary artery disease" EXACT [MONDO:patterns/location, NCIT:C26732] +synonym: "coronary artery disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "coronary disease" EXACT [DOID:3393, NCIT:C26732] +synonym: "coronary heart disease" EXACT [DOID:3393, MONDO:0000016, NCIT:C26732] +synonym: "disease of coronary artery" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of coronary artery" EXACT [] +synonym: "disorder of coronary artery" EXACT [MONDO:patterns/location_top] +xref: DOID:3393 {source="EFO:0000378", source="MONDO:equivalentTo"} +xref: EFO:0001645 {source="MONDO:equivalentTo", source="DOID:3393"} +xref: GARD:0011944 {source="MONDO:equivalentTo"} +xref: ICD9:410-414.99 {source="EFO:0001645", source="DOID:3393"} +xref: ICD9:414.0 {source="EFO:0000378", source="DOID:3393"} +xref: ICD9:414.9 {source="DOID:3393"} +xref: MESH:D003324 {source="EFO:0000378", source="MONDO:equivalentTo", source="DOID:3393"} +xref: MESH:D017202 {source="DOID:3393", source="MONDO:directSiblingOf"} +xref: NCIT:C26732 {source="EFO:0000378", source="MONDO:equivalentTo", source="EFO:0001645"} +xref: SCTID:414024009 {source="MONDO:equivalentTo"} +xref: SCTID:414545008 {source="EFO:0001645", source="DOID:3393", source="MONDO:directSiblingOf"} +xref: UMLS:C0151744 {source="DOID:3393", source="MONDO:directSiblingOf"} +xref: UMLS:C1956346 {source="MONDO:equivalentTo", source="NCIT:C26732"} +is_a: MONDO:0000473 {source="DOID:3393", source="MONDO:Redundant"} ! arterial disorder +is_a: MONDO:0005267 {source="EFO:0000378/inferred", source="MESH:D003324/inferred", source="MONDO:Redundant", source="NCIT:C26732/inferred"} ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001621 ! coronary artery +relationship: disease_has_location UBERON:0000948 {source="EFO:0000784"} ! heart +relationship: disease_has_location UBERON:0001621 ! coronary artery +property_value: exactMatch DOID:3393 +property_value: exactMatch http://identifiers.org/mesh/D003324 +property_value: exactMatch http://identifiers.org/snomedct/414024009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1956346 +property_value: exactMatch NCIT:C26732 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005015 +name: diabetes mellitus +def: "A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization." [NCIT:P378] +synonym: "diabetes" EXACT [NCIT:C2985] +synonym: "diabetes mellitus" EXACT [MONDO:ambiguous, NCIT:C2985] +synonym: "diabetes mellitus (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "DM" EXACT ABBREVIATION [NCIT:C2985] +xref: DOID:9351 {source="EFO:0000400", source="MONDO:equivalentTo"} +xref: EFO:0000400 {source="MONDO:equivalentTo"} +xref: HP:0000819 {source="MONDO:otherHierarchy"} +xref: ICD10CM:E08-E13 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="DOID:9351", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:250 {source="EFO:0000400", source="DOID:9351"} +xref: MESH:D003920 {source="EFO:0000400", source="MONDO:equivalentTo", source="DOID:9351"} +xref: NCIT:C2985 {source="EFO:0000400", source="MONDO:equivalentTo", source="DOID:9351"} +xref: SCTID:73211009 {source="EFO:0000400", source="MONDO:equivalentTo", source="DOID:9351"} +xref: UMLS:C0011847 {source="MONDO:equivalentTo"} +xref: UMLS:C0011849 {source="MONDO:equivalentTo", source="DOID:9351", source="NCIT:C2985"} +is_a: MONDO:0001933 {source="NCIT:C2985"} ! endocrine pancreas disorder +is_a: MONDO:0002908 {source="DOID:9351", source="MESH:D003920", source="NCIT:C2985"} ! glucose metabolism disease +relationship: disease_causes_feature HP:0003074 ! Hyperglycemia +property_value: exactMatch DOID:9351 +property_value: exactMatch http://identifiers.org/mesh/D003920 +property_value: exactMatch http://identifiers.org/snomedct/73211009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011847 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011849 +property_value: exactMatch https://icd.codes/icd10cm/E08-E13 +property_value: exactMatch NCIT:C2985 +property_value: IAO:0000589 "diabetes mellitus (disease)" xsd:string + +[Term] +id: MONDO:0005020 +name: intestinal disorder +def: "A non-neoplastic or neoplastic disorder that affects the small or large intestine." [NCIT:C26801] +synonym: "disease of intestine" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of intestine" EXACT [] +synonym: "disease, intestinal" RELATED [MESH:D007410] +synonym: "diseases, intestinal" RELATED [MESH:D007410] +synonym: "disorder of intestine" EXACT [MONDO:patterns/location_top] +synonym: "intestinal disease" EXACT [MESH:D007410] +synonym: "intestinal disorder" EXACT [NCIT:C26801] +synonym: "intestine disease" EXACT [MONDO:patterns/location] +synonym: "intestine disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:5295 {source="MONDO:equivalentTo", source="EFO:0000405"} +xref: ICD9:520-579.99 {source="EFO:0000405"} +xref: ICD9:560-569.99 {source="EFO:0000405"} +xref: ICD9:564 {source="EFO:0000405"} +xref: ICD9:564.4 {source="EFO:0000405"} +xref: ICD9:569 {source="EFO:0000405"} +xref: ICD9:569.4 {source="EFO:0000405"} +xref: ICD9:569.49 {source="EFO:0000405"} +xref: ICD9:569.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:569.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:5295"} +xref: ICD9:570-579.99 {source="EFO:0000405"} +xref: ICD9:575 {source="EFO:0000405"} +xref: MESH:D007410 {source="MONDO:equivalentTo", source="DOID:5295", source="EFO:0000405"} +xref: NCIT:C26801 {source="MONDO:equivalentTo", source="DOID:5295"} +xref: SCTID:85919009 {source="MONDO:equivalentTo", source="DOID:5295"} +is_a: MONDO:0004335 {source="DOID:5295", source="MESH:D007410", source="MONDO:Redundant", source="NCIT:C26801"} ! digestive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000160 ! intestine +relationship: disease_has_location UBERON:0000160 ! intestine +property_value: exactMatch DOID:5295 +property_value: exactMatch http://identifiers.org/mesh/D007410 +property_value: exactMatch http://identifiers.org/snomedct/85919009 +property_value: exactMatch NCIT:C26801 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005025 +name: endocarditis +def: "Inflammation of the endocardium." [NCIT:C34582] +synonym: "endocarditis" EXACT [MONDO:ambiguous] +synonym: "endocarditis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "endocardium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of endocardium" EXACT [] +xref: DOID:10314 {source="MONDO:equivalentTo", source="EFO:0000465"} +xref: EFO:0000465 {source="MONDO:equivalentTo"} +xref: HP:0100584 {source="MONDO:otherHierarchy"} +xref: ICD9:421.9 {source="DOID:10314", source="EFO:0000465"} +xref: ICD9:424.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D004696 {source="DOID:10314", source="MONDO:equivalentTo", source="EFO:0000465"} +xref: NCIT:C34582 {source="DOID:10314", source="MONDO:equivalentTo", source="EFO:0000465"} +xref: SCTID:56819008 {source="DOID:10314", source="MONDO:equivalentTo", source="EFO:0000465"} +is_a: MONDO:0000470 {source="DOID:10314", source="MONDO:Redundant"} ! endocardium disorder +is_a: MONDO:0024636 ! inflammation of heart layer +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002165 ! endocardium +relationship: disease_has_inflammation_site UBERON:0002165 ! endocardium +property_value: exactMatch DOID:10314 +property_value: exactMatch http://identifiers.org/mesh/D004696 +property_value: exactMatch http://identifiers.org/snomedct/56819008 +property_value: exactMatch NCIT:C34582 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "endocarditis (disease)" xsd:string + +[Term] +id: MONDO:0005026 +name: endometrioid adenocarcinoma +def: "An adenocarcinoma characterized by the presence of malignant glandular epithelial cells resembling endometrial cells. It can arise from the uterine body, ovary, fallopian tube, cervix, vagina, and uterine ligament." [NCIT:C3769] +synonym: "endometrioid adenocarcinoma" EXACT [NCIT:C3769] +synonym: "endometrioid carcinoma" EXACT [NCIT:C3769] +synonym: "endometrioid carcinoma of female reproductive system" EXACT [NCIT:C3769] +synonym: "endometrioid carcinoma of the female reproductive system" EXACT [NCIT:C3769] +synonym: "female reproductive endometrioid carcinoma" EXACT [NCIT:C3769] +xref: EFO:0000466 {source="MONDO:equivalentTo"} +xref: ICDO:8380/3 {source="NCIT:C3769"} +xref: NCIT:C3769 {source="EFO:0000466", source="MONDO:equivalentTo"} +xref: UMLS:C0206687 {source="MONDO:equivalentTo", source="NCIT:C3769"} +xref: UMLS:C1569637 {source="MONDO:equivalentTo"} +is_a: MONDO:0001416 {source="NCIT:C3769"} ! female reproductive organ cancer +is_a: MONDO:0004970 {source="MONDO:equivalentTo", source="NCIT:C3769"} ! adenocarcinoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206687 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1569637 +property_value: exactMatch NCIT:C3769 + +[Term] +id: MONDO:0005027 +name: epilepsy +def: "A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions." [NCIT:P378] +synonym: "epilepsy" EXACT [] +synonym: "seizure disorder" EXACT [NCIT:C3020] +xref: DOID:1826 {source="MONDO:equivalentTo"} +xref: EFO:0000474 {source="MONDO:equivalentTo", source="DOID:1826"} +xref: ICD10CM:G40 {source="MONDO:equivalentTo"} +xref: ICD10WHO:G40 {source="MONDO:equivalentTo"} +xref: ICD9:345 {source="EFO:0000474"} +xref: ICD9:345.8 {source="EFO:0000474"} +xref: ICD9:345.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:345.9 {source="EFO:0000474", source="DOID:1826"} +xref: ICD9:345.90 {source="EFO:0000474", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:345.91 {source="EFO:0000474"} +xref: MESH:D004827 {source="EFO:0000474", source="MONDO:equivalentTo", source="DOID:1826"} +xref: NCIT:C3020 {source="EFO:0000474", source="MONDO:equivalentTo", source="DOID:1826"} +xref: NIFSTD:birnlex_12718 {source="EFO:0000474"} +xref: SCTID:84757009 {source="EFO:0000474", source="MONDO:equivalentTo", source="DOID:1826"} +is_a: MONDO:0005560 {source="DOID:1826", source="MESH:D004827"} ! brain disorder +relationship: disease_has_feature HP:0001250 ! Seizure +property_value: exactMatch DOID:1826 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/G40 +property_value: exactMatch http://identifiers.org/mesh/D004827 +property_value: exactMatch http://identifiers.org/snomedct/84757009 +property_value: exactMatch https://icd.codes/icd10cm/G40 +property_value: exactMatch NCIT:C3020 + +[Term] +id: MONDO:0005028 +name: esophageal adenocarcinoma +def: "A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor." [NCIT:C4025] +subset: ordo_disease {source="Orphanet:99976"} +synonym: "adenocarcinoma - esophagus" EXACT [NCIT:C4025] +synonym: "adenocarcinoma of esophagus" EXACT [DOID:4914, MONDO:0020565, NCIT:C4025] +synonym: "adenocarcinoma of the esophagus" EXACT [NCIT:C4025] +synonym: "esophageal adenocarcinoma" EXACT [NCIT:C4025, Orphanet:99976] +synonym: "esophagus adenocarcinoma" EXACT [MONDO:0003201, MONDO:patterns/location, NCIT:C4025] +synonym: "oesophageal adenocarcinoma" EXACT [DOID:4914] +xref: DOID:4914 {source="MONDO:equivalentTo", source="EFO:0000478"} +xref: EFO:0000478 {source="MONDO:equivalentTo"} +xref: ICD10CM:C15.5 {source="Orphanet:99976/btnt", source="Orphanet:99976"} +xref: NCIT:C4025 {source="MONDO:equivalentTo", source="EFO:0000478", source="DOID:4914"} +xref: OMIM:614266 {source="Orphanet:99976/ntbt", source="MONDO:relatedTo", source="Orphanet:99976"} +xref: ONCOTREE:ESCA {source="MONDO:equivalentTo"} +xref: Orphanet:99976 {source="MONDO:equivalentTo"} +xref: SCTID:276803003 {source="MONDO:equivalentTo", source="EFO:0000478", source="DOID:4914"} +xref: UMLS:C0279628 {source="Orphanet:99976", source="MONDO:equivalentTo", source="NCIT:C4025", source="DOID:4914"} +is_a: MONDO:0004970 {source="EFO:0000478", source="MONDO:Redundant", source="NCIT:C4025"} ! adenocarcinoma +is_a: MONDO:0019086 {source="DOID:4914", source="MONDO:Redundant", source="NCIT:C4025", source="Orphanet:99976"} ! carcinoma of esophagus +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: broadMatch https://icd.codes/icd10cm/C15.5 +property_value: exactMatch DOID:4914 +property_value: exactMatch http://identifiers.org/snomedct/276803003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279628 +property_value: exactMatch NCIT:C4025 +property_value: exactMatch Orphanet:99976 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005034 +name: thyroid gland follicular carcinoma +def: "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. The nuclear features which characterize the thyroid gland papillary carcinoma are absent. Radiation exposure is a risk factor and it comprises approximately 10% to 15% of thyroid cancers. Clinically, it usually presents as a solitary mass in the thyroid gland. It is generally unifocal and thickly encapsulated and shows invasion of the capsule or the vessels. Diagnostic procedures include thyroid ultrasound and fine needle biopsy." [NCIT:C8054] +synonym: "carcinoma of thyroid follicle" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, follicular cell, malignant" EXACT [NCIT:C8054] +synonym: "follicular adenocarcinoma" NARROW [NCIT:C8054] +synonym: "follicular adenocarcinoma (morphologic abnormality)" NARROW [DOID:3962] +synonym: "follicular adenocarcinoma, well differentiated" NARROW [DOID:3962] +synonym: "follicular adenocarcinoma, well differentiated (morphologic abnormality)" NARROW [DOID:3962] +synonym: "follicular cancer of the thyroid" BROAD [NCIT:C8054] +synonym: "follicular cancer of the thyroid gland" BROAD [NCIT:C8054] +synonym: "follicular cancer of thyroid" BROAD [NCIT:C8054] +synonym: "follicular cancer of thyroid gland" BROAD [NCIT:C8054] +synonym: "follicular carcinoma" EXACT [DOID:3962, NCIT:C8054] +synonym: "follicular carcinoma of the thyroid" EXACT [NCIT:C8054] +synonym: "follicular carcinoma of the thyroid gland" EXACT [DOID:3962, NCIT:C8054] +synonym: "follicular carcinoma of thyroid" EXACT [NCIT:C8054] +synonym: "follicular carcinoma of thyroid gland" EXACT [NCIT:C8054] +synonym: "follicular thyroid cancer" EXACT [NCIT:C8054] +synonym: "follicular thyroid carcinoma" EXACT [MONDO:ambiguous, NCIT:C8054] +synonym: "follicular thyroid gland carcinoma" EXACT [NCIT:C8054] +synonym: "thyroid follicle carcinoma" EXACT [] +synonym: "thyroid follicular carcinoma" EXACT [NCIT:C8054] +synonym: "thyroid gland adenocarcinoma" NARROW [MONDO:patterns/location] +synonym: "thyroid gland follicular cancer" BROAD [NCIT:C8054] +synonym: "thyroid gland follicular carcinoma" EXACT [NCIT:C8054] +synonym: "well-differentiated follicular adenocarcinoma" EXACT [NCIT:C8054] +synonym: "well-differentiated follicular carcinoma" BROAD [NCIT:C8054] +xref: DOID:3962 {source="MONDO:equivalentTo", source="EFO:0000501"} +xref: EFO:0000501 {source="MONDO:equivalentTo"} +xref: HP:0006731 {source="MONDO:otherHierarchy"} +xref: ICDO:8330/3 {source="NCIT:C8054"} +xref: ICDO:8331/3 {source="NCIT:C8054"} +xref: MESH:D018263 {source="DOID:3962", source="MONDO:equivalentTo", source="EFO:0000501"} +xref: NCIT:C27380 {source="EFO:0000501", source="MONDO:directSiblingOf"} +xref: NCIT:C8054 {source="DOID:3962", source="MONDO:equivalentTo", source="EFO:0000501"} +xref: ONCOTREE:THFO {source="MONDO:equivalentTo"} +xref: SCTID:255028004 {source="DOID:3962", source="MONDO:equivalentTo", source="EFO:0000501"} +is_a: MONDO:0015447 {source="EFO:0000501", source="NCIT:C8054", source="ONCOTREE:THFO"} ! differentiated thyroid carcinoma +is_a: MONDO:0024622 ! thyroid gland adenocarcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0005305 ! thyroid follicle +relationship: disease_has_location UBERON:0005305 ! thyroid follicle +property_value: exactMatch DOID:3962 +property_value: exactMatch http://identifiers.org/mesh/D018263 +property_value: exactMatch http://identifiers.org/snomedct/255028004 +property_value: exactMatch NCIT:C8054 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005036 +name: gastric adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the stomach" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma - stomach" EXACT [NCIT:C4004] +synonym: "adenocarcinoma of stomach" EXACT [NCIT:C4004] +synonym: "adenocarcinoma of the stomach" EXACT [NCIT:C4004] +synonym: "gastric (stomach) adenocarcinoma" EXACT [NCIT:C4004] +synonym: "gastric adenocarcinoma" EXACT [NCIT:C4004] +synonym: "STAD" RELATED ABBREVIATION [ONCOTREE:STAD] +synonym: "stomach adenocarcinoma" EXACT [DOID:3717, MONDO:patterns/location, NCIT:C4004] +xref: DOID:3717 {source="MONDO:equivalentTo", source="EFO:0000503"} +xref: EFO:0000503 {source="MONDO:equivalentTo"} +xref: NCIT:C4004 {source="MONDO:equivalentTo", source="EFO:0000503", source="MONDO:exact-label-match", source="DOID:3717"} +xref: ONCOTREE:STAD {source="MONDO:equivalentTo"} +xref: Orphanet:464463 {source="MONDO:equivalentTo"} +xref: SCTID:408647009 {source="MONDO:equivalentTo", source="EFO:0000503", source="DOID:3717"} +xref: UMLS:C0278701 {source="MONDO:equivalentTo", source="NCIT:C4004", source="DOID:3717"} +is_a: MONDO:0004950 {source="DOID:3717", source="MONDO:Redundant", source="NCIT:C4004"} ! gastric carcinoma +is_a: MONDO:0004970 {source="DOID:3717", source="EFO:0000503", source="MONDO:Redundant", source="NCIT:C4004"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:3717 +property_value: exactMatch http://identifiers.org/snomedct/408647009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278701 +property_value: exactMatch NCIT:C4004 +property_value: exactMatch Orphanet:464463 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005039 +name: reproductive system disorder +def: "A disease involving the reproductive system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of reproductive system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of reproductive system" EXACT [] +synonym: "disorder of reproductive system" EXACT [MONDO:patterns/location_top, NCIT:C4875] +synonym: "genital disorders" EXACT [NCIT:C4875] +synonym: "genital system disease" EXACT [DOID:15] +synonym: "reproductive disease" EXACT [DOID:15] +synonym: "reproductive system disease" EXACT [MONDO:patterns/location, NCIT:C4875] +synonym: "reproductive system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "reproductive system disorder" EXACT [NCIT:C4875] +xref: DOID:15 {source="MONDO:equivalentTo", source="EFO:0000512"} +xref: EFO:0000512 {source="MONDO:equivalentTo"} +xref: NCIT:C4875 {source="MONDO:equivalentTo"} +xref: SCTID:362968007 {source="MONDO:equivalentTo", source="EFO:0000512"} +xref: UMLS:C0178829 {source="MONDO:equivalentTo", source="NCIT:C4875"} +xref: Wikipedia:Reproductive_system_disease {source="EFO:0000512"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000990 ! reproductive system +relationship: disease_has_location UBERON:0000990 ! reproductive system +property_value: exactMatch DOID:15 +property_value: exactMatch http://identifiers.org/snomedct/362968007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0178829 +property_value: exactMatch NCIT:C4875 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005040 +name: germ cell tumor +def: "A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor." [NCIT:C3708] +subset: gard_rare +synonym: "germ cell cancer" RELATED [DOID:2994] +synonym: "germ cell neoplasm" EXACT [DOID:2994, NCIT:C3708] +synonym: "germ cell tumor" EXACT [NCIT:C3708] +synonym: "germ cell tumour" RELATED [DOID:2994] +synonym: "germ cells tumors" RELATED [GARD:0013022] +synonym: "neoplasm of germ cell" EXACT [NCIT:C3708] +synonym: "neoplasm of the germ cell" EXACT [NCIT:C3708] +synonym: "tumor of germ cell" EXACT [NCIT:C3708] +synonym: "tumor of the germ cell" EXACT [NCIT:C3708] +xref: DOID:2994 {source="MONDO:equivalentTo", source="EFO:0000514"} +xref: DOID:688 {source="EFO:0000514", source="MONDO:directSiblingOf"} +xref: EFO:0000514 {source="MONDO:equivalentTo"} +xref: GARD:0013022 {source="MONDO:equivalentTo"} +xref: NCIT:C3708 {source="DOID:2994", source="MONDO:equivalentTo", source="EFO:0000514"} +xref: UMLS:C0205851 {source="DOID:2994", source="NCIT:C3708", source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="DOID:2994/inferred", source="EFO:0000514", source="MONDO:Redundant", source="NCIT:C3708/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000586 ! germ cell +relationship: disease_arises_from_structure CL:0000586 ! germ cell +property_value: exactMatch DOID:2994 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0205851 +property_value: exactMatch NCIT:C3708 + +[Term] +id: MONDO:0005041 +name: glaucoma +def: "Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor." [NCIT:P378] +synonym: "glaucoma" EXACT [MONDO:ambiguous] +synonym: "glaucoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1686 {source="MONDO:equivalentTo", source="EFO:0000516"} +xref: EFO:0000516 {source="MONDO:equivalentTo", source="DOID:1686"} +xref: HP:0000501 {source="MONDO:otherHierarchy"} +xref: ICD10CM:H40-H42 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="DOID:1686", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:365 {source="DOID:1686", source="EFO:0000516"} +xref: ICD9:365.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:365.9 {source="MONDO:equivalentTo", source="DOID:1686", source="MONDO:i2s"} +xref: MESH:D005901 {source="MONDO:equivalentTo", source="DOID:1686", source="EFO:0000516"} +xref: NCIT:C26782 {source="MONDO:equivalentTo", source="DOID:1686", source="EFO:0000516"} +xref: SCTID:23986001 {source="MONDO:equivalentTo", source="DOID:1686", source="EFO:0000516"} +xref: UMLS:C0017601 {source="NCIT:C26782", source="MONDO:equivalentTo", source="DOID:1686"} +is_a: MONDO:0005328 {source="DOID:1686", source="MESH:D005901/inferred", source="NCIT:C26782/inferred"} ! eye disorder +property_value: exactMatch DOID:1686 +property_value: exactMatch http://identifiers.org/mesh/D005901 +property_value: exactMatch http://identifiers.org/snomedct/23986001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017601 +property_value: exactMatch https://icd.codes/icd10cm/H40-H42 +property_value: exactMatch NCIT:C26782 +property_value: IAO:0000589 "glaucoma (disease)" xsd:string + +[Term] +id: MONDO:0005042 +name: head disorder +def: "A disease involving the head." [MONDO:patterns/location_top] +comment: Reason: grouping class specific to autosomal disorder. Term to consider: none. +subset: obsoletion_candidate +synonym: "disease of head" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of head" EXACT [] +synonym: "disorder of head" EXACT [MONDO:patterns/location_top] +synonym: "head disease" EXACT [MONDO:patterns/location] +synonym: "head disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: EFO:0000524 {source="MONDO:equivalentTo"} +xref: SCTID:118934005 {source="MONDO:equivalentTo"} +xref: UMLS:C1290856 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000033 ! head +relationship: disease_has_location UBERON:0000033 ! head +property_value: exactMatch http://identifiers.org/snomedct/118934005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290856 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: IAO:0006012 "2022-08-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4621 + +[Term] +id: MONDO:0005043 +name: hyperplasia +def: "An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement." [NCIT:C3113] +synonym: "hyperplasia" EXACT [NCIT:C3113] +synonym: "hyperplastic" EXACT [NCIT:C3113] +xref: EFO:0000536 {source="MONDO:equivalentTo"} +xref: MESH:D006965 {source="MONDO:equivalentTo", source="EFO:0000536"} +xref: NCIT:C3113 {source="MONDO:equivalentTo", source="EFO:0000536", source="MONDO:exact-label-match"} +is_a: MONDO:0045024 {source="MONDO:Redundant", source="MONDO:cjm"} ! cancer or benign tumor +property_value: exactMatch http://identifiers.org/mesh/D006965 +property_value: exactMatch NCIT:C3113 + +[Term] +id: MONDO:0005044 +name: hypertensive disorder +def: "Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more." [MESH:D006973] +synonym: "blood pressure, high" EXACT [NCIT:C3117] +synonym: "blood pressure, increased" EXACT [NCIT:C3117] +synonym: "high blood pressure" EXACT [DOID:10763] +synonym: "HTN" BROAD ABBREVIATION [DOID:10763] +synonym: "hyperpiesia" EXACT [DOID:10763] +synonym: "hypertension" RELATED [DOID:10763] +synonym: "hypertensive disease" EXACT [DOID:10763, MTH:NOCODE] +synonym: "increased blood pressure" EXACT [NCIT:C3117] +synonym: "pressure, high blood" EXACT [NCIT:C3117] +synonym: "vascular hypertensive disorder" EXACT [DOID:10763, NCIT:C3117] +xref: DOID:10763 {source="MONDO:equivalentTo", source="EFO:0000537"} +xref: EFO:0000537 {source="DOID:10763", source="MONDO:equivalentTo"} +xref: HP:0000822 {source="MONDO:otherHierarchy"} +xref: ICD10CM:I10-I16 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10CM:I15 {source="MONDO:equivalentTo"} +xref: ICD9:401-405.99 {source="DOID:10763", source="EFO:0000537"} +xref: ICD9:997.91 {source="DOID:10763"} +xref: MESH:D006973 {source="DOID:10763", source="MONDO:equivalentTo", source="EFO:0000537"} +xref: NCIT:C3117 {source="DOID:10763", source="MONDO:equivalentTo", source="MONDO:otherHierarchy", source="MONDO:exact-label-match", source="EFO:0000537"} +xref: SCTID:38341003 {source="DOID:10763", source="MONDO:equivalentTo"} +xref: UMLS:C0020538 {source="DOID:10763", source="MONDO:equivalentTo"} +is_a: MONDO:0000473 {source="DOID:10763"} ! arterial disorder +relationship: disease_arises_from_feature HP:0000822 ! Hypertension +relationship: disease_has_location UBERON:0004573 ! systemic artery +property_value: exactMatch DOID:10763 +property_value: exactMatch http://identifiers.org/mesh/D006973 +property_value: exactMatch http://identifiers.org/snomedct/38341003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020538 +property_value: exactMatch https://icd.codes/icd10cm/I10-I16 +property_value: exactMatch https://icd.codes/icd10cm/I15 +property_value: exactMatch NCIT:C3117 + +[Term] +id: MONDO:0005046 +name: immune system disorder +def: "A disorder resulting from an abnormality in the immune system." [NCIT:C3507] +synonym: "disease of immune system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of immune system" EXACT [] +synonym: "disorder of immune system" EXACT [MONDO:patterns/location_top, NCIT:C3507] +synonym: "immune disease" EXACT [DOID:2914] +synonym: "immune disorder" EXACT [NCIT:C3507] +synonym: "immune dysfunction" EXACT [NCIT:C3507] +synonym: "immune system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "immune system disorder" EXACT [NCIT:C3507] +xref: DOID:2914 {source="EFO:0000540", source="MONDO:equivalentTo"} +xref: EFO:0000540 {source="MONDO:equivalentTo", source="DOID:2914"} +xref: ICD9:279 {source="EFO:0000540", source="DOID:2914"} +xref: ICD9:279.1 {source="EFO:0000540"} +xref: ICD9:279.10 {source="EFO:0000540"} +xref: ICD9:279.19 {source="EFO:0000540"} +xref: ICD9:279.4 {source="EFO:0000540"} +xref: ICD9:279.49 {source="EFO:0000540"} +xref: ICD9:279.8 {source="MONDO:relatedTo", source="EFO:0000540", source="MONDO:i2s"} +xref: ICD9:279.9 {source="EFO:0000540", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2914"} +xref: MESH:D007154 {source="MONDO:equivalentTo"} +xref: NCIT:C3507 {source="MONDO:equivalentTo"} +xref: SCTID:414029004 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002405 ! immune system +relationship: disease_has_location UBERON:0002405 ! immune system +property_value: exactMatch DOID:2914 +property_value: exactMatch http://identifiers.org/mesh/D007154 +property_value: exactMatch http://identifiers.org/snomedct/414029004 +property_value: exactMatch NCIT:C3507 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005047 +name: infertility disorder +def: "Inability to conceive for at least one year after trying and having unprotected sex. Causes of female infertility include endometriosis, fallopian tubes obstruction, and polycystic ovary syndrome. Causes of male infertility include abnormal sperm production or function, blockage of the epididymis, blockage of the ejaculatory ducts, hypospadias, exposure to pesticides, and health related issues." [NCIT:C3836] +comment: Editor note: dubious as to whether this is a disease as defined, check with clingen before obsoleting +subset: clingen +synonym: "fertility disorders" EXACT [NCIT:C3836] +synonym: "infertile" EXACT [NCIT:C3836] +synonym: "infertility" RELATED [DOID:5223] +synonym: "Sterile" EXACT [NCIT:C3836] +synonym: "sterile" EXACT [NCIT:C3836] +synonym: "sterility" EXACT [NCIT:C3836] +xref: DOID:5223 {source="MONDO:equivalentTo", source="EFO:0000545"} +xref: EFO:0000545 {source="MONDO:equivalentTo"} +xref: MESH:D007246 {source="DOID:5223", source="MONDO:equivalentTo", source="EFO:0000545"} +xref: NCIT:C3836 {source="DOID:5223", source="MONDO:equivalentTo", source="MONDO:otherHierarchy", source="EFO:0000545", source="MONDO:exact-label-match"} +is_a: MONDO:0005039 {source="DOID:5223", source="EFO:0000545", source="MESH:D007246/inferred"} ! reproductive system disorder +relationship: disease_has_feature HP:0000789 ! Infertility +property_value: exactMatch DOID:5223 +property_value: exactMatch http://identifiers.org/mesh/D007246 +property_value: exactMatch NCIT:C3836 + +[Term] +id: MONDO:0005051 +name: invasive lobular breast carcinoma +def: "An infiltrating lobular adenocarcinoma of the breast. The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma. The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures." [NCIT:C7950] +synonym: "breast invasive lobular carcinoma" RELATED [ONCOTREE:ILC] +synonym: "classic invasive lobular carcinoma" EXACT [NCIT:C7950] +synonym: "infiltrating lobular adenocarcinoma" EXACT [NCIT:C7950] +synonym: "infiltrating lobular breast carcinoma" EXACT [NCIT:C7950] +synonym: "infiltrating lobular carcinoma of breast" EXACT [NCIT:C7950] +synonym: "infiltrating lobular carcinoma of the breast" EXACT [NCIT:C7950] +synonym: "invasive lobular adenocarcinoma" EXACT [NCIT:C7950] +synonym: "invasive lobular breast carcinoma" EXACT [NCIT:C7950] +synonym: "invasive lobular carcinoma" EXACT [NCIT:C7950] +synonym: "invasive lobular carcinoma of breast" EXACT [NCIT:C7950] +synonym: "invasive lobular carcinoma of the breast" EXACT [NCIT:C7950] +synonym: "invasive lobular carcinoma, classic type" EXACT [NCIT:C7950] +synonym: "lobular carcinoma" BROAD [DOID:3457] +synonym: "lobular carcinoma (morphologic abnormality)" BROAD [DOID:3457] +synonym: "lobular carcinoma NOS (morphologic abnormality)" BROAD [DOID:3457] +synonym: "lobular carcinoma of the breast" BROAD [DOID:3457] +xref: DOID:3457 {source="MONDO:equivalentTo", source="EFO:0000553"} +xref: EFO:0000553 {source="MONDO:equivalentTo"} +xref: NCIT:C7950 {source="MONDO:equivalentTo", source="EFO:0000553"} +xref: ONCOTREE:ILC {source="MONDO:equivalentTo"} +xref: UMLS:C0206692 {source="MONDO:equivalentTo", source="DOID:3457"} +xref: UMLS:C0279565 {source="NCIT:C7950", source="MONDO:equivalentTo"} +is_a: MONDO:0000552 {source="DOID:3457", source="MONDO:Redundant", source="NCIT:C7950"} ! breast lobular carcinoma +is_a: MONDO:0006256 {source="MONDO:Redundant", source="NCIT:C7950", source="ONCOTREE:ILC"} ! invasive breast carcinoma +intersection_of: MONDO:0000552 ! breast lobular carcinoma +intersection_of: has_modifier PATO:0002129 ! neoplastic, invasive +property_value: exactMatch DOID:3457 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206692 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279565 +property_value: exactMatch NCIT:C7950 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0005061 +name: lung adenocarcinoma +def: "A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor." [NCIT:C3512] +subset: gard_rare {source="GARD:0005742"} +synonym: "adenocarcinoma of lung" EXACT [DOID:3910, NCIT:C3512] +synonym: "adenocarcinoma of the lung" EXACT [NCIT:C3512] +synonym: "bronchogenic lung adenocarcinoma" EXACT [DOID:3910] +synonym: "lung adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C3512] +synonym: "non-small cell lung adenocarcinoma" EXACT [MONDO:0005474] +synonym: "nonsmall cell adenocarcinoma" EXACT [DOID:3910] +xref: DOID:3910 {source="EFO:0005288", source="EFO:0000571", source="MONDO:equivalentTo"} +xref: EFO:0000571 {source="MONDO:equivalentTo", source="DOID:3910"} +xref: EFO:0005288 {source="MONDO:equivalentTo"} +xref: GARD:0005742 {source="MONDO:equivalentTo"} +xref: MESH:C538231 {source="EFO:0000571", source="MONDO:equivalentTo", source="DOID:3910"} +xref: NCIT:C3512 {source="EFO:0005288", source="EFO:0000571", source="MONDO:equivalentTo", source="DOID:3910"} +xref: ONCOTREE:LUAD {source="MONDO:equivalentTo"} +xref: Orphanet:415268 {source="MONDO:equivalentTo"} +xref: SCTID:254626006 {source="EFO:0000571", source="MONDO:equivalentTo", source="DOID:3910"} +xref: UMLS:C0152013 {source="MONDO:equivalentTo", source="DOID:3910", source="NCIT:C3512"} +is_a: MONDO:0004970 {source="DOID:3910", source="EFO:0005288", source="MESH:C538231", source="MONDO:Redundant", source="NCIT:C3512/inferred"} ! adenocarcinoma +is_a: MONDO:0005233 {source="DOID:3910", source="EFO:0005288", source="NCIT:C3512", source="ONCOTREE:LUAD"} ! non-small cell lung carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:3910 +property_value: exactMatch http://identifiers.org/mesh/C538231 +property_value: exactMatch http://identifiers.org/snomedct/254626006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152013 +property_value: exactMatch NCIT:C3512 +property_value: exactMatch Orphanet:415268 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5742/lung-adenocarcinoma xsd:anyURI {source="GARD:0005742"} + +[Term] +id: MONDO:0005062 +name: lymphoma +def: "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas." [NCIT:C3208] +comment: This is potentially too broad as well as overlaps with leukemia and should be obsoleted. {source="EFO:0000574"} +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:223735"} +synonym: "lymphoid cancer" EXACT [DOID:0060058] +synonym: "lymphoma" EXACT [MONDO:0016389, NCIT:C3208] +synonym: "lymphoma (Hodgkin and non-Hodgkin)" EXACT [NCIT:C3208] +synonym: "lymphoma (Hodgkin's and non-Hodgkin's)" EXACT [NCIT:C3208] +synonym: "lymphoma, malignant" EXACT [NCIT:C3208] +synonym: "lymphomatous" EXACT [NCIT:C3208] +synonym: "malignant lymphoma" EXACT [MONDO:cjm, NCIT:C3208] +synonym: "MLYM" RELATED ABBREVIATION [ONCOTREE:MLYM] +xref: DOID:0060058 {source="EFO:0000574", source="MONDO:equivalentTo"} +xref: EFO:0000574 {source="MONDO:equivalentTo"} +xref: GARD:0011955 {source="MONDO:equivalentTo"} +xref: ICD9:200.0 {source="EFO:0000574"} +xref: ICD9:200.1 {source="EFO:0000574"} +xref: ICD9:202.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:9590/3 {source="NCIT:C3208"} +xref: MedDRA:10025310 {source="Orphanet:223735", source="Orphanet:223735/e"} +xref: MESH:D008223 {source="EFO:0000574", source="DOID:0060058", source="MONDO:equivalentTo", source="Orphanet:223735", source="Orphanet:223735/e"} +xref: NCIT:C3208 {source="EFO:0000574", source="DOID:0060058", source="MONDO:equivalentTo"} +xref: ONCOTREE:MLYM {source="MONDO:equivalentTo"} +xref: Orphanet:223735 {source="MONDO:equivalentTo"} +xref: SCTID:118600007 {source="EFO:0000574", source="DOID:0060058", source="MONDO:equivalentTo"} +xref: UMLS:C0024299 {source="DOID:0060058", source="MONDO:equivalentTo", source="Orphanet:223735", source="NCIT:C3208", source="Orphanet:223735/e"} +is_a: MONDO:0005157 {source="EFO:0000574", source="NCIT:C3208"} ! lymphoid neoplasm +is_a: MONDO:0015757 {source="Orphanet:223735"} ! lymphoid hemopathy +property_value: closeMatch http://identifiers.org/meddra/10025310 +property_value: exactMatch DOID:0060058 +property_value: exactMatch http://identifiers.org/mesh/D008223 +property_value: exactMatch http://identifiers.org/snomedct/118600007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024299 +property_value: exactMatch NCIT:C3208 +property_value: exactMatch Orphanet:223735 + +[Term] +id: MONDO:0005066 +name: metabolic disease +def: "A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process." [NCIT:C3235] +subset: harrisons_view +synonym: "disease of metabolism" RELATED [DOID:0014667] +synonym: "disorder of metabolic process" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "metabolic disease" EXACT [DOID:0014667, NCIT:C3235] +synonym: "metabolic disorder" EXACT [NCIT:C3235] +synonym: "metabolic process disease" EXACT [MONDO:design_pattern] +xref: DOID:0014667 {source="MONDO:equivalentTo", source="EFO:0000589"} +xref: EFO:0000589 {source="MONDO:equivalentTo"} +xref: ICD10CM:E70-E88 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10WHO:E70-E90 {source="MONDO:equivalentTo"} +xref: ICD9:277.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:277.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0000589", source="DOID:0014667"} +xref: MESH:D008659 {source="MONDO:equivalentTo", source="EFO:0000589", source="DOID:0014667"} +xref: NCIT:C3235 {source="MONDO:equivalentTo", source="EFO:0000589", source="DOID:0014667"} +xref: SCTID:75934005 {source="MONDO:equivalentTo", source="EFO:0000589", source="DOID:0014667"} +xref: UMLS:C0025517 {source="MONDO:equivalentTo", source="NCIT:C3235", source="DOID:0014667"} +is_a: MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/3155", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0008152 ! metabolic process +relationship: disease_has_basis_in_disruption_of GO:0008152 ! metabolic process +property_value: exactMatch DOID:0014667 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/E70-E90 +property_value: exactMatch http://identifiers.org/mesh/D008659 +property_value: exactMatch http://identifiers.org/snomedct/75934005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025517 +property_value: exactMatch https://icd.codes/icd10cm/E70-E88 +property_value: exactMatch NCIT:C3235 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0005070 +name: neoplasm +def: "A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias." [NCIT:C3262] +synonym: "cell process disease" BROAD DUBIOUS [DOID:14566] +synonym: "disease of cellular proliferation" EXACT [MONDO:0002001] +synonym: "neoplasia" EXACT [NCIT:C3262] +synonym: "neoplasm" EXACT [DOID:14566, MONDO:ambiguous, NCIT:C3262] +synonym: "neoplasm (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "neoplastic disease" EXACT [NCIT:C3262] +synonym: "neoplastic growth" EXACT [NCIT:C3262] +synonym: "other neoplasm" NARROW [NCIT:C3262] +synonym: "tumor" EXACT [NCIT:C3262] +synonym: "tumor disease" EXACT [] +xref: DOID:14566 {source="MONDO:equivalentTo"} +xref: EFO:0000616 {source="MONDO:equivalentTo"} +xref: HP:0002664 {source="MONDO:otherHierarchy"} +xref: ICD10CM:C00-D49 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:140-239.99 {source="EFO:0000616"} +xref: ICD9:239.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:239.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009369 {source="MONDO:equivalentTo", source="EFO:0000616"} +xref: NCIT:C3262 {source="MONDO:equivalentTo", source="EFO:0000616"} +xref: ONCOTREE:OTHER +xref: SCTID:55342001 {source="MONDO:equivalentTo"} +xref: UMLS:CN236628 {source="MONDO:equivalentTo"} +is_a: MONDO:0023370 {source="MONDO:Redundant", source="MONDO:cjm"} ! neoplastic disease or syndrome +property_value: exactMatch DOID:14566 +property_value: exactMatch http://identifiers.org/mesh/D009369 +property_value: exactMatch http://identifiers.org/snomedct/55342001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236628 +property_value: exactMatch https://icd.codes/icd10cm/C00-D49 +property_value: exactMatch NCIT:C3262 +property_value: IAO:0000589 "neoplasm (disease)" xsd:string + +[Term] +id: MONDO:0005071 +name: nervous system disorder +def: "A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves." [NCIT:C26835] +comment: 'psychiatric disorder' is not classified as a 'nervous system disorder' in Mondo (though it is often as such): the hallmarks of psychiatric disorders are based in behavior and emotional state, and the relation with nervous system malfunction or damage is not always clearly determined. +synonym: "disease of nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nervous system" EXACT [] +synonym: "disorder of nervous system" EXACT [MONDO:patterns/location_top, NCIT:C26835] +synonym: "nervous system disease" EXACT [MONDO:patterns/location] +synonym: "nervous system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "nervous system disorder" EXACT [NCIT:C26835] +synonym: "neurologic disease" EXACT [DOID:863] +synonym: "neurologic disorder" EXACT [DOID:863, ISBN-13:978-1-259-64403-0, NCIT:C26835] +synonym: "neurological disease" EXACT [DOID:863] +synonym: "neurological disorder" EXACT [DOID:863] +xref: DOID:863 {source="EFO:0000618", source="MONDO:equivalentTo"} +xref: EFO:0000618 {source="MONDO:equivalentTo"} +xref: ICD10CM:G00-G99 {source="DOID:863", source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:349.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:349.9 {source="DOID:863", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009422 {source="DOID:863", source="MONDO:equivalentTo"} +xref: NCIT:C26835 {source="DOID:863", source="MONDO:equivalentTo", source="NCIT:C26835"} +xref: SCTID:118940003 {source="DOID:863", source="MONDO:equivalentTo"} +xref: UMLS:C0027765 {source="DOID:863", source="MONDO:equivalentTo", source="NCIT:C26835"} +xref: Wikipedia:Nervous_system_disease {source="EFO:0000618"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001016 ! nervous system +relationship: disease_has_location UBERON:0001016 ! nervous system +property_value: exactMatch DOID:863 +property_value: exactMatch http://identifiers.org/mesh/D009422 +property_value: exactMatch http://identifiers.org/snomedct/118940003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027765 +property_value: exactMatch https://icd.codes/icd10cm/G00-G99 +property_value: exactMatch NCIT:C26835 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005073 +name: melanocytic nevus +def: "A neoplasm composed of melanocytes that usually appears as a dark spot on the skin." [NCIT:C7570] +synonym: "melanocytic Nevus" EXACT [NCIT:C7570] +synonym: "melanotic Nevus" EXACT [NCIT:C7570] +synonym: "mole" EXACT [NCIT:C7570] +synonym: "mole of skin" EXACT [NCIT:C7570] +synonym: "nevus" EXACT [NCIT:C7570] +xref: EFO:0000625 {source="MONDO:equivalentTo"} +xref: MESH:D009506 {source="MONDO:equivalentTo", source="EFO:0000625"} +xref: NCIT:C7570 {source="MONDO:equivalentTo"} +xref: SCTID:400096001 {source="MONDO:equivalentTo"} +xref: Wikipedia:Nevus {source="EFO:0000625"} +is_a: MONDO:0021440 ! benign neoplasm of skin +is_a: MONDO:0021583 ! melanocytic skin neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_arises_from_structure CL:0000148 ! melanocyte +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch http://identifiers.org/mesh/D009506 +property_value: exactMatch http://identifiers.org/snomedct/400096001 +property_value: exactMatch NCIT:C7570 + +[Term] +id: MONDO:0005076 +name: periodontitis +def: "An acute or chronic inflammatory process that affects the tissues that surround and support the teeth." [NCIT:P378] +synonym: "chronic pericementitis" EXACT [DOID:824] +synonym: "inflammation of periodontium" EXACT [] +synonym: "periodontium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "periodontosis" RELATED [DOID:9893] +xref: DOID:824 {source="MONDO:equivalentTo", source="EFO:0000649"} +xref: DOID:9893 {source="MONDO:equivalentTo"} +xref: EFO:0000649 {source="DOID:824", source="MONDO:equivalentTo"} +xref: ICD10CM:K05.4 {source="MONDO:equivalentTo", source="DOID:9893"} +xref: ICD9:523.5 {source="DOID:9893"} +xref: MESH:D010518 {source="DOID:824", source="MONDO:equivalentTo", source="EFO:0000649"} +xref: NCIT:C34918 {source="DOID:824", source="MONDO:equivalentTo", source="EFO:0000649"} +xref: SCTID:41565005 {source="DOID:824", source="MONDO:equivalentTo", source="EFO:0000649"} +xref: UMLS:C0031099 {source="DOID:824", source="NCIT:C34918", source="MONDO:equivalentTo"} +xref: UMLS:C0600298 {source="MONDO:equivalentTo", source="DOID:9893"} +is_a: MONDO:0002635 {source="DOID:824", source="MESH:D010518", source="MONDO:Redundant", source="NCIT:C34918"} ! periodontal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001758 ! periodontium +relationship: disease_has_inflammation_site UBERON:0001758 ! periodontium +property_value: exactMatch DOID:824 +property_value: exactMatch DOID:9893 +property_value: exactMatch http://identifiers.org/mesh/D010518 +property_value: exactMatch http://identifiers.org/snomedct/41565005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031099 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0600298 +property_value: exactMatch https://icd.codes/icd10cm/K05.4 +property_value: exactMatch NCIT:C34918 +property_value: excluded_subClassOf MONDO:0006999 {source="DOID:9893"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005082 +name: prostate adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the prostate gland" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of prostate" EXACT [NCIT:C2919] +synonym: "adenocarcinoma of the prostate" EXACT [NCIT:C2919] +synonym: "prad" RELATED [ONCOTREE:PRAD] +synonym: "prostate adenocarcinoma" EXACT [NCIT:C2919] +synonym: "prostate gland adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:2526 {source="EFO:0000673", source="MONDO:equivalentTo"} +xref: EFO:0000673 {source="MONDO:equivalentTo"} +xref: NCIT:C2919 {source="EFO:0000673", source="MONDO:equivalentTo", source="DOID:2526", source="MONDO:exact-label-match"} +xref: ONCOTREE:PRAD {source="MONDO:equivalentTo"} +xref: SCTID:399490008 {source="EFO:0000673", source="MONDO:equivalentTo", source="DOID:2526"} +xref: UMLS:C0007112 {source="MONDO:equivalentTo", source="NCIT:C2919", source="DOID:2526"} +is_a: MONDO:0004970 {source="DOID:2526", source="EFO:0000673", source="MONDO:Redundant", source="NCIT:C2919"} ! adenocarcinoma +is_a: MONDO:0005159 {source="DOID:2526", source="EFO:0000673", source="MONDO:Redundant", source="NCIT:C2919/inferred"} ! prostate carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:2526 +property_value: exactMatch http://identifiers.org/snomedct/399490008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007112 +property_value: exactMatch NCIT:C2919 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005084 +name: mental disorder +def: "A disease that has its basis in the disruption of mental process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of mental process" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "mental or behavioural disorder" EXACT [DOID:2468] +synonym: "mental process disease" EXACT [MONDO:design_pattern] +xref: EFO:0000677 {source="DOID:2468", source="MONDO:equivalentTo"} +xref: ICD9:290-299.99 {source="EFO:0000677"} +xref: ICD9:298.8 {source="DOID:2468"} +xref: ICD9:V11.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NIFSTD:birnlex_12669 {source="EFO:0000677"} +xref: SCTID:74732009 {source="MONDO:equivalentTo", source="EFO:0000677"} +xref: UMLS:CN240636 {source="MONDO:equivalentTo"} +is_a: MONDO:0002025 ! psychiatric disorder +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of MF:0000020 ! mental process +relationship: disease_has_basis_in_disruption_of MF:0000020 ! mental process +property_value: exactMatch http://identifiers.org/snomedct/74732009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN240636 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0005086 +name: renal cell carcinoma +def: "A carcinoma that arises from glandular epithelial cells of the kidney" [https://orcid.org/0000-0002-6601-2165] +subset: disease_grouping +subset: gard_rare +subset: ordo_group_of_disorders {source="Orphanet:217071"} +synonym: "hypernephroma" EXACT [DOID:4450] +synonym: "kidney adenocarcinoma" RELATED [MONDO:patterns/location] +synonym: "RCC" EXACT ABBREVIATION [DOID:4450, Orphanet:217071] +synonym: "renal cell adenocarcinoma" RELATED [GARD:0013215] +synonym: "renal cell carcinoma" EXACT [MONDO:ambiguous] +synonym: "renal cell carcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:4450 {source="EFO:0000681", source="MONDO:equivalentTo"} +xref: EFO:0000681 {source="MONDO:equivalentTo", source="DOID:4450"} +xref: GARD:0013215 {source="MONDO:equivalentTo"} +xref: HP:0005584 {source="MONDO:otherHierarchy"} +xref: ICD9:189.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10067946 {source="Orphanet:217071", source="Orphanet:217071/e"} +xref: MESH:D002292 {source="EFO:0000681", source="Orphanet:217071", source="MONDO:equivalentTo", source="Orphanet:217071/e", source="DOID:4450"} +xref: NCIT:C9385 {source="EFO:0000681", source="GARD:0013215", source="MONDO:directSiblingOf", source="DOID:4450"} +xref: ONCOTREE:RCC {source="MONDO:equivalentTo"} +xref: Orphanet:217071 {source="MONDO:equivalentTo"} +xref: SCTID:702391001 {source="EFO:0000681", source="MONDO:equivalentTo", source="DOID:4450"} +is_a: MONDO:0004970 {source="DOID:4450", source="MESH:D002292", source="MONDO:Redundant"} ! adenocarcinoma +is_a: MONDO:0005206 {source="DOID:4450", source="EFO:0000681", source="MONDO:Redundant"} ! renal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002113 ! kidney +relationship: has_modifier MONDO:0021136 {source="MONDO:0019749"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10067946 +property_value: exactMatch DOID:4450 +property_value: exactMatch http://identifiers.org/mesh/D002292 +property_value: exactMatch http://identifiers.org/snomedct/702391001 +property_value: exactMatch Orphanet:217071 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: IAO:0000589 "renal cell carcinoma (disease)" xsd:string + +[Term] +id: MONDO:0005087 +name: respiratory system disorder +def: "A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma." [NCIT:C26871] +synonym: "disease of respiratory system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of respiratory system" EXACT [] +synonym: "disorder of respiratory system" EXACT [MONDO:patterns/location_top, NCIT:C26871] +synonym: "respiratory disease" EXACT [DOID:1579] +synonym: "respiratory disorder" EXACT [NCIT:C26871] +synonym: "respiratory system disease" EXACT [MONDO:patterns/location] +synonym: "respiratory system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "respiratory system disorder" EXACT [NCIT:C26871] +xref: DOID:1579 {source="EFO:0000684", source="MONDO:equivalentTo"} +xref: EFO:0000684 {source="MONDO:equivalentTo"} +xref: ICD10CM:J00-J99 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:460-519.99 {source="EFO:0000684"} +xref: ICD9:500-508.99 {source="EFO:0000684"} +xref: ICD9:503 {source="EFO:0000684"} +xref: ICD9:508 {source="EFO:0000684"} +xref: ICD9:508.1 {source="EFO:0000684"} +xref: ICD9:508.8 {source="EFO:0000684"} +xref: ICD9:508.9 {source="EFO:0000684"} +xref: ICD9:510-519.99 {source="EFO:0000684", source="DOID:1579"} +xref: ICD9:516 {source="EFO:0000684"} +xref: ICD9:516.8 {source="EFO:0000684"} +xref: ICD9:516.9 {source="EFO:0000684"} +xref: ICD9:517 {source="EFO:0000684"} +xref: ICD9:517.8 {source="EFO:0000684"} +xref: ICD9:519 {source="EFO:0000684", source="DOID:1579"} +xref: ICD9:519.1 {source="EFO:0000684"} +xref: ICD9:519.3 {source="EFO:0000684"} +xref: ICD9:519.8 {source="MONDO:relatedTo", source="EFO:0000684", source="MONDO:i2s"} +xref: ICD9:519.9 {source="EFO:0000684", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:V12.60 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:V47.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012140 {source="MONDO:equivalentTo"} +xref: NCIT:C26871 {source="EFO:0000684", source="MONDO:equivalentTo"} +xref: SCTID:50043002 {source="EFO:0000684", source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001004 ! respiratory system +relationship: disease_has_location UBERON:0001004 {source="EFO:0000784", source="NCIT:C26871"} ! respiratory system +property_value: exactMatch DOID:1579 +property_value: exactMatch http://identifiers.org/mesh/D012140 +property_value: exactMatch http://identifiers.org/snomedct/50043002 +property_value: exactMatch https://icd.codes/icd10cm/J00-J99 +property_value: exactMatch NCIT:C26871 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005090 +name: schizophrenia +def: "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." [NCIT:P378] +synonym: "schizoaffective disorder" RELATED [OMIM:181500] +synonym: "schizophrenia" EXACT [MONDO:ambiguous, MONDO:Lexical, OMIM:181500] +synonym: "schizophrenia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "schizophrenia 12" BROAD [OMIM:181500, OMIM:genemap2] +synonym: "schizophrenia with or without an affective disorder" RELATED [OMIM:181500] +synonym: "schizophrenia, susceptibility to" RELATED [OMIM:181500, OMIM:genemap2] +synonym: "schizophrenia-1" EXACT [DOID:5419] +synonym: "SCZD" RELATED ABBREVIATION [MONDO:Lexical, OMIM:181500] +xref: DOID:5419 {source="EFO:0000692", source="MONDO:equivalentTo"} +xref: EFO:0000692 {source="MONDO:equivalentTo", source="DOID:5419"} +xref: HP:0100753 {source="MONDO:otherHierarchy", source="DOID:5419"} +xref: ICD9:295 {source="EFO:0000692"} +xref: ICD9:295.8 {source="EFO:0000692", source="DOID:5419"} +xref: ICD9:295.80 {source="MONDO:relatedTo", source="MONDO:i2s", source="DOID:5419"} +xref: ICD9:295.85 {source="EFO:0000692"} +xref: ICD9:295.9 {source="EFO:0000692"} +xref: ICD9:295.90 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3362 {source="EFO:0000692", source="MONDO:equivalentTo"} +xref: NIFSTD:birnlex_2104 {source="EFO:0000692"} +xref: OMIM:181500 {source="EFO:0000692", source="MONDO:equivalentTo", source="DOID:5419"} +xref: Orphanet:3140 {source="MONDO:equivalentTo"} +xref: SCTID:58214004 {source="EFO:0000692", source="MONDO:equivalentTo"} +is_a: MONDO:0005485 {source="DOID:5419", source="MONDO:cjm"} ! psychotic disorder +property_value: exactMatch DOID:5419 +property_value: exactMatch http://identifiers.org/snomedct/58214004 +property_value: exactMatch https://omim.org/entry/181500 +property_value: exactMatch NCIT:C3362 +property_value: exactMatch Orphanet:3140 +property_value: IAO:0000589 "schizophrenia (disease)" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0005093 +name: skin disorder +def: "Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs." [NCIT:C3371] +synonym: "cutaneous disorder" EXACT [NCIT:C3371] +synonym: "dermatosis" NARROW [https://medical-dictionary.thefreedictionary.com/dermatosis] +synonym: "disease of zone of skin" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of zone of skin" EXACT [] +synonym: "disorder of skin" EXACT [NCIT:C3371] +synonym: "disorder of zone of skin" EXACT [MONDO:patterns/location_top] +synonym: "genodermatosis" NARROW [DOID:37] +synonym: "skin and subcutaneous tissue disease" EXACT [DOID:37] +synonym: "skin diseases and manifestations" EXACT [NCIT:C3371] +synonym: "skin disorder" EXACT [NCIT:C3371] +synonym: "zone of skin disease" EXACT [MONDO:patterns/location] +synonym: "zone of skin disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:37 {source="MONDO:equivalentTo", source="EFO:0000701"} +xref: EFO:0000701 {source="MONDO:equivalentTo"} +xref: ICD9:702 {source="DOID:37"} +xref: ICD9:702.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:709.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012871 {source="DOID:37", source="MONDO:equivalentTo"} +xref: NCIT:C3371 {source="DOID:37", source="MONDO:equivalentTo", source="EFO:0000701"} +xref: SCTID:95320005 {source="DOID:37", source="MONDO:equivalentTo"} +is_a: MONDO:0002051 {source="DOID:37", source="MONDO:Redundant"} ! integumentary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +relationship: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch DOID:37 +property_value: exactMatch http://identifiers.org/mesh/D012871 +property_value: exactMatch http://identifiers.org/snomedct/95320005 +property_value: exactMatch NCIT:C3371 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005096 +name: squamous cell carcinoma +def: "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma." [NCIT:C2929] +synonym: "carcinoma, squamous cell, malignant" EXACT [NCIT:C2929] +synonym: "epidermoid carcinoma" EXACT [DOID:1749, NCIT:C2929] +synonym: "epidermoid cell cancer" EXACT [NCIT:C2929] +synonym: "malignant epidermoid cell neoplasm" EXACT [NCIT:C2929] +synonym: "malignant epidermoid cell tumor" EXACT [NCIT:C2929] +synonym: "malignant squamous cell neoplasm" EXACT [NCIT:C2929] +synonym: "malignant squamous cell tumor" EXACT [DOID:1749, NCIT:C2929, NCIT:C4971] +synonym: "squamous carcinoma" EXACT [DOID:1749, NCIT:C2929] +synonym: "squamous cell cancer" EXACT [DOID:1749, NCIT:C2929] +synonym: "squamous cell carcinoma" EXACT [NCIT:C2929] +synonym: "squamous cell carcinoma (morphologic abnormality)" EXACT [DOID:1749] +synonym: "squamous cell carcinoma NOS (morphologic abnormality)" EXACT [DOID:1749] +synonym: "squamous cell epithelioma" EXACT [DOID:1749, NCIT:C2929, NCIT:C8999] +xref: DOID:1749 {source="EFO:0000707", source="MONDO:equivalentTo"} +xref: EFO:0000707 {source="MONDO:equivalentTo", source="DOID:1749"} +xref: GARD:0001091 {source="MONDO:equivalentTo"} +xref: ICDO:8070/3 {source="NCIT:C2929"} +xref: MESH:D002294 {source="EFO:0000707", source="MONDO:equivalentTo", source="DOID:1749"} +xref: NCIT:C2929 {source="EFO:0000707", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:1749"} +xref: SCTID:402815007 {source="EFO:0000707", source="MONDO:equivalentTo", source="DOID:1749"} +xref: UMLS:C0007137 {source="MONDO:equivalentTo", source="NCIT:C2929", source="DOID:1749"} +is_a: MONDO:0002532 {source="MESH:D002294", source="NCIT:C2929"} ! squamous cell neoplasm +is_a: MONDO:0004993 {source="DOID:1749", source="EFO:0000707", source="EFO:0000707/inferred", source="MESH:D002294", source="MONDO:Redundant", source="NCIT:C2929"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure CL:0000076 ! squamous epithelial cell +relationship: disease_arises_from_structure CL:0000076 ! squamous epithelial cell +property_value: exactMatch DOID:1749 +property_value: exactMatch http://identifiers.org/mesh/D002294 +property_value: exactMatch http://identifiers.org/snomedct/402815007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007137 +property_value: exactMatch NCIT:C2929 + +[Term] +id: MONDO:0005097 +name: squamous cell lung carcinoma +def: "A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma." [NCIT:C3493] +comment: In DO this is classified as nscLC, but this leads to logical issues as we have a distinct class for squamous nscLC +synonym: "epidermoid cell carcinoma of lung" EXACT [NCIT:C3493] +synonym: "epidermoid cell carcinoma of the lung" EXACT [DOID:3907, NCIT:C3493] +synonym: "epidermoid cell lung carcinoma" EXACT [NCIT:C3493] +synonym: "lung squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of lung" EXACT [DOID:3907, NCIT:C3493] +synonym: "squamous cell carcinoma of the lung" EXACT [NCIT:C3493] +synonym: "squamous cell lung cancer" EXACT [NCIT:C3493] +synonym: "squamous cell lung carcinoma" EXACT [NCIT:C3493] +xref: DOID:3907 {source="EFO:0000708", source="MONDO:equivalentTo"} +xref: EFO:0000708 {source="MONDO:equivalentTo"} +xref: ICD9:162.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3493 {source="DOID:3907", source="EFO:0000708", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:LUSC {source="MONDO:equivalentTo"} +xref: SCTID:254634000 {source="DOID:3907", source="EFO:0000708", source="MONDO:equivalentTo"} +xref: UMLS:C0149782 {source="DOID:3907", source="NCIT:C3493", source="MONDO:equivalentTo"} +is_a: MONDO:0005096 {source="DOID:3907", source="EFO:0000708", source="MONDO:Redundant", source="NCIT:C3493"} ! squamous cell carcinoma +is_a: MONDO:0005138 {source="DOID:3907/inferred", source="EFO:0000708", source="MONDO:Redundant", source="NCIT:C3493"} ! lung carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:3907 +property_value: exactMatch http://identifiers.org/snomedct/254634000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149782 +property_value: exactMatch NCIT:C3493 +property_value: excluded_subClassOf MONDO:0005233 {source="DOID:3907", source="ONCOTREE:LUSC"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0005098 +name: stroke disorder +def: "A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event." [NCIT:C3390] +comment: Stroke includes two main types, hemorrhagic and ischemic. Both types of stroke can cause acute seizures at the time of the acute event, as well as epilepsy as a long-term complication. In the elderly, cerebrovascular disease and stroke are the most common cause of acute seizures and epilepsy. {xref="https://orcid.org/0000-0001-5208-3432", xref="https://www.epilepsydiagnosis.org/aetiology/stroke-overview.html"} +synonym: "cerebral infarction" RELATED [NCIT:C3390] +synonym: "cerebrovascular accident" EXACT [NCIT:C3390] +synonym: "cerebrovascular accident, (CVA)" EXACT [NCIT:C3390] +synonym: "CVA" EXACT ABBREVIATION [NCIT:C3390] +synonym: "CVA, cerebrovascular accident" EXACT [NCIT:C3390] +synonym: "stroke" EXACT [NCIT:C3390] +synonym: "stroke syndrome" EXACT [NCIT:C3390] +synonym: "syndrome, stroke" EXACT [NCIT:C3390] +synonym: "undetermined stroke" EXACT [NCIT:C3390] +xref: EFO:0000712 {source="MONDO:equivalentTo"} +xref: HP:0001297 +xref: MESH:D020521 {source="MONDO:equivalentTo", source="EFO:0000712"} +xref: NCIT:C3390 {source="MONDO:equivalentTo", source="EFO:0000712"} +xref: NIFSTD:birnlex_12783 {source="EFO:0000712"} +xref: SCTID:230690007 {source="MONDO:equivalentTo", source="EFO:0000712"} +is_a: MONDO:0011057 {source="MESH:D020521", source="NCIT:C3390"} ! cerebrovascular disorder +relationship: disease_has_feature MONDO:0100035 {source="https://orcid.org/0000-0001-8486-0558"} ! structural epilepsy +relationship: disease_has_location UBERON:0003499 {source="EFO:0000784"} ! brain blood vessel +relationship: disease_has_major_feature HP:0001297 ! Stroke +property_value: exactMatch http://identifiers.org/mesh/D020521 +property_value: exactMatch http://identifiers.org/snomedct/230690007 +property_value: exactMatch NCIT:C3390 + +[Term] +id: MONDO:0005108 +name: viral infectious disease +def: "Any disease caused by a virus." [NCIT:P378] +synonym: "infection, viral" EXACT [NCIT:C3439] +synonym: "infections, Viruses" RELATED [MONDO:patterns/infectious_disease_by_agent] +synonym: "viral disease" EXACT [DOID:934, NCIT:C3439] +synonym: "viral disorder" EXACT [NCIT:C3439] +synonym: "viral infection" EXACT [DOID:934, NCIT:C3439] +synonym: "virus infection" EXACT [DOID:934] +synonym: "Viruses caused disease or disorder" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses disease or disorder" EXACT [] +synonym: "Viruses infection" EXACT [MONDO:patterns/infectious_disease_by_agent] +synonym: "Viruses infectious disease" EXACT [] +xref: DOID:934 {source="EFO:0000763", source="MONDO:equivalentTo"} +xref: EFO:0000763 {source="MONDO:equivalentTo"} +xref: ICD9:060-066.99 {source="DOID:934"} +xref: ICD9:066.9 {source="DOID:934"} +xref: ICD9:078.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:079.99 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D014777 {source="DOID:934", source="MONDO:equivalentTo"} +xref: NCIT:C3439 {source="DOID:934", source="MONDO:equivalentTo"} +xref: SCTID:34014006 {source="DOID:934", source="EFO:0000763", source="MONDO:equivalentTo"} +is_a: MONDO:0005550 {source="DOID:934", source="EFO:0000763", source="MONDO:Redundant", source="NCIT:C3439"} ! infectious disease +is_a: MONDO:0100321 ! viral disease or post-viral disorder +intersection_of: MONDO:0100321 ! viral disease or post-viral disorder +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +disjoint_from: MONDO:0005247 ! bacterial urinary tract infection +relationship: disease_has_infectious_agent NCBITaxon:10239 {source="MONDO:Wikidata"} ! Viruses +property_value: exactMatch DOID:934 +property_value: exactMatch http://identifiers.org/mesh/D014777 +property_value: exactMatch http://identifiers.org/snomedct/34014006 +property_value: exactMatch NCIT:C3439 + +[Term] +id: MONDO:0005110 +name: idiopathic cardiomyopathy +def: "A disease of the heart muscle or myocardium proper whose cause is unknown." [NCIT:C53654] +xref: EFO:0000767 {source="MONDO:equivalentTo"} +xref: NCIT:C53654 {source="MONDO:equivalentTo", source="EFO:0000767"} +is_a: MONDO:0004994 {source="EFO:0000767", source="NCIT:C53654"} ! cardiomyopathy +is_a: MONDO:0700007 ! idiopathic disease +intersection_of: MONDO:0004994 ! cardiomyopathy +intersection_of: has_modifier MONDO:0700005 ! idiopathic +property_value: exactMatch NCIT:C53654 + +[Term] +id: MONDO:0005113 +name: bacterial infectious disease +def: "An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections." [NCIT:C2890] +synonym: "Bacteria caused disease or disorder" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria disease or disorder" EXACT [] +synonym: "Bacteria infectious disease" EXACT [] +synonym: "bacterial disease" EXACT [NCIT:C2890] +synonym: "bacterial disorder" EXACT [NCIT:C2890] +synonym: "bacterial infection" EXACT [MESH:D001424, NCIT:C2890] +synonym: "bacterial infectious disease" EXACT [MONDO:0001026] +synonym: "infection, bacterial" EXACT [MESH:D001424, NCIT:C2890] +synonym: "infections, bacterial" RELATED [MESH:D001424] +xref: DOID:104 {source="MONDO:equivalentTo"} +xref: EFO:0000771 {source="MONDO:equivalentTo"} +xref: ICD9:040.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:041.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:041.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001424 {source="DOID:104", source="MONDO:equivalentTo"} +xref: NCIT:C2890 {source="DOID:104", source="MONDO:equivalentTo"} +xref: SCTID:87628006 {source="DOID:104", source="MONDO:equivalentTo"} +xref: UMLS:C0004623 {source="DOID:104", source="NCIT:C2890", source="MONDO:equivalentTo"} +is_a: MONDO:0005550 {source="DOID:104", source="EFO:0000771", source="MONDO:Redundant", source="NCIT:C2890"} ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +relationship: disease_has_infectious_agent NCBITaxon:2 {source="MONDO:Wikidata"} ! Bacteria +property_value: exactMatch DOID:104 +property_value: exactMatch http://identifiers.org/mesh/D001424 +property_value: exactMatch http://identifiers.org/snomedct/87628006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004623 +property_value: exactMatch NCIT:C2890 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/infectious_disease_by_agent.yaml + +[Term] +id: MONDO:0005115 +name: temporal lobe epilepsy +def: "A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see epilepsy, complex partial) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)" [MESH:D004833] +synonym: "epilepsy of temporal lobe" EXACT [MONDO:design_pattern] +synonym: "epilepsy, familial temporal lobe" RELATED [OMIMPS:600512] +synonym: "epilepsy, temporal lobe" EXACT [DOID:3328] +synonym: "temporal lobe epilepsy" EXACT [MONDO:patterns/location] +xref: DOID:3328 {source="MONDO:equivalentTo", source="EFO:0000773"} +xref: EFO:0000773 {source="MONDO:equivalentTo"} +xref: MESH:D004833 {source="MONDO:equivalentTo", source="EFO:0000773", source="DOID:3328"} +xref: NIFSTD:birnlex_12733 {source="EFO:0000773"} +xref: OMIMPS:600512 {source="MONDO:equivalentTo"} +xref: SCTID:783739005 {source="MONDO:equivalentTo"} +xref: UMLS:C1842564 {source="MONDO:equivalentTo"} +is_a: MONDO:0017704 ! familial partial epilepsy +intersection_of: MONDO:0005027 ! epilepsy +intersection_of: disease_has_location UBERON:0001871 ! temporal lobe +relationship: disease_has_location UBERON:0001871 ! temporal lobe +property_value: exactMatch DOID:3328 +property_value: exactMatch http://identifiers.org/mesh/D004833 +property_value: exactMatch http://identifiers.org/snomedct/783739005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1842564 +property_value: exactMatch https://omim.org/phenotypicSeries/PS600512 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005129 +name: cataract +def: "Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)" [NCIT:C26713] +synonym: "cataract" EXACT [MONDO:ambiguous] +synonym: "cataract (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "opacity of the lens" EXACT [NCIT:C26713] +xref: DOID:83 {source="MONDO:equivalentTo", source="EFO:0001059"} +xref: EFO:0001059 {source="MONDO:equivalentTo"} +xref: HP:0000518 {source="MONDO:otherHierarchy"} +xref: ICD9:366 {source="EFO:0001059"} +xref: ICD9:366.44 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:366.8 {source="MONDO:relatedTo", source="MONDO:i2s", source="DOID:83"} +xref: ICD9:366.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D002386 {source="MONDO:equivalentTo", source="EFO:0001059", source="DOID:83"} +xref: NCIT:C26713 {source="MONDO:equivalentTo", source="EFO:0001059", source="NCIT:C26713"} +xref: OMIMPS:116200 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: SCTID:193570009 {source="MONDO:equivalentTo", source="EFO:0001059"} +is_a: MONDO:0001176 {source="DOID:83", source="MESH:D002386", source="NCIT:C26713"} ! lens disorder +is_a: MONDO:0003847 ! Mendelian disease +property_value: exactMatch DOID:83 +property_value: exactMatch http://identifiers.org/mesh/D002386 +property_value: exactMatch http://identifiers.org/snomedct/193570009 +property_value: exactMatch https://omim.org/phenotypicSeries/PS116200 +property_value: exactMatch NCIT:C26713 +property_value: IAO:0000589 "cataract (disease)" xsd:string +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005131 +name: cervical carcinoma +def: "A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma." [NCIT:C9039] +synonym: "cancer of cervix" BROAD [DOID:2893, NCIT:C9039] +synonym: "cancer of the cervix" BROAD [NCIT:C9039] +synonym: "cancer of the uterine cervix" BROAD [NCIT:C9039] +synonym: "cancer of uterine cervix" BROAD [NCIT:C9039] +synonym: "carcinoma cervix uteri" EXACT [DOID:2893] +synonym: "carcinoma of cervix" EXACT [DOID:2893, MTH:166, NCIT:C9039] +synonym: "carcinoma of cervix uteri" EXACT [NCIT:C9039] +synonym: "carcinoma of the cervix" EXACT [NCIT:C9039] +synonym: "carcinoma of the cervix uteri" EXACT [DOID:2893, NCIT:C9039] +synonym: "carcinoma of the uterine cervix" EXACT [NCIT:C9039] +synonym: "carcinoma of uterine cervix" EXACT [MONDO:patterns/carcinoma, NCIT:C9039] +synonym: "cervical cancer" BROAD [NCIT:C9039] +synonym: "cervical cancer, NOS" BROAD [NCIT:C9039] +synonym: "cervical carcinoma" EXACT [NCIT:C9039] +synonym: "cervix cancer" BROAD [NCIT:C9039] +synonym: "cervix carcinoma" EXACT [MONDO:0002456, NCIT:C9039] +synonym: "cervix uteri carcinoma" EXACT [NCIT:C9039] +synonym: "uterine cervix cancer" BROAD [NCIT:C9039] +synonym: "uterine cervix carcinoma" EXACT [MONDO:patterns/location, NCIT:C9039] +xref: DOID:2893 {source="MONDO:equivalentTo", source="EFO:0001061"} +xref: EFO:0001061 {source="MONDO:equivalentTo"} +xref: NCIT:C9039 {source="DOID:2893", source="MONDO:equivalentTo", source="EFO:0001061"} +xref: SCTID:285432005 {source="DOID:2893", source="MONDO:equivalentTo", source="EFO:0001061"} +xref: UMLS:C0302592 {source="DOID:2893", source="NCIT:C9039", source="MONDO:equivalentTo"} +is_a: MONDO:0002974 {source="DOID:2893", source="MONDO:Redundant", source="NCIT:C9039"} ! cervical cancer +is_a: MONDO:0005213 ! uterine carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +relationship: disease_arises_from_structure UBERON:0004801 {source="NCIT:C9039"} ! cervix epithelium +property_value: exactMatch DOID:2893 +property_value: exactMatch http://identifiers.org/snomedct/285432005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0302592 +property_value: exactMatch NCIT:C9039 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005137 +name: nutritional disorder +def: "Any condition related to a disturbance between proper intake and utilization of nourishment." [NCIT:C26836] +subset: harrisons_view +synonym: "nutrition disease" RELATED [DOID:374] +synonym: "nutritional disorder" EXACT [DOID:374, NCIT:C26836] +xref: DOID:374 {source="EFO:0001069", source="MONDO:equivalentTo"} +xref: EFO:0001069 {source="MONDO:equivalentTo"} +xref: ICD9:783.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009748 {source="EFO:0001069", source="MONDO:equivalentTo", source="DOID:374"} +xref: NCIT:C26836 {source="EFO:0001069", source="MONDO:equivalentTo", source="DOID:374", source="MONDO:exact-label-match"} +xref: SCTID:2492009 {source="EFO:0001069", source="MONDO:equivalentTo", source="DOID:374"} +xref: UMLS:C3714509 {source="MONDO:equivalentTo", source="DOID:374", source="NCIT:C26836"} +is_a: MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/3155", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} ! disease or disorder +property_value: exactMatch DOID:374 +property_value: exactMatch http://identifiers.org/mesh/D009748 +property_value: exactMatch http://identifiers.org/snomedct/2492009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3714509 +property_value: exactMatch NCIT:C26836 +property_value: excluded_subClassOf MONDO:0005066 {source="NCIT:C26836"} +property_value: excluded_subClassOf MONDO:0006504 {source="DOID:374"} + +[Term] +id: MONDO:0005138 +name: lung carcinoma +def: "A carcinoma that arises from epithelial cells of the lung" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of lung" BROAD [DOID:3905, NCIT:C4878] +synonym: "cancer of the lung" BROAD [NCIT:C4878] +synonym: "carcinoma of lung" EXACT [DOID:3905, MONDO:patterns/carcinoma, NCIT:C4878] +synonym: "carcinoma of the lung" EXACT [NCIT:C4878] +synonym: "lung cancer" BROAD [NCIT:C4878] +synonym: "lung cancer, NOS" BROAD [NCIT:C4878] +synonym: "lung carcinoma" EXACT [MONDO:patterns/location, NCIT:C4878] +xref: DOID:3905 {source="MONDO:equivalentTo", source="EFO:0001071"} +xref: EFO:0001071 {source="MONDO:equivalentTo", source="DOID:3905"} +xref: NCIT:C4878 {source="MONDO:equivalentTo", source="EFO:0001071", source="DOID:3905"} +xref: UMLS:C0684249 {source="MONDO:equivalentTo", source="NCIT:C4878", source="DOID:3905"} +is_a: MONDO:0004993 {source="DOID:3905", source="EFO:0001071", source="MONDO:Redundant", source="NCIT:C4878"} ! carcinoma +is_a: MONDO:0008903 {source="DOID:3905", source="MONDO:Redundant", source="NCIT:C4878"} ! lung cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002048 ! lung +relationship: disease_has_feature HP:0001824 ! Weight loss +relationship: disease_has_feature HP:0002105 ! Hemoptysis +property_value: exactMatch DOID:3905 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684249 +property_value: exactMatch NCIT:C4878 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005140 +name: ovarian carcinoma +def: "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002" [NCIT:C4908] +comment: Editor note: unclear why this is distinct from malignant ovarian epithelial tumor in NCIT. +synonym: "carcinoma of ovary" EXACT [MONDO:patterns/carcinoma, NCIT:C4908] +synonym: "carcinoma of the ovary" EXACT [NCIT:C4908] +synonym: "epithelial ovarian cancer" EXACT [NCIT:C4908] +synonym: "ovarian cancer" BROAD [NCIT:C4908] +synonym: "ovarian carcinoma" EXACT [DOID:4001, NCIT:C4908] +synonym: "ovarian epithelial cancer" BROAD [NCIT:C4908] +synonym: "ovary carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4001 {source="EFO:0001075", source="MONDO:equivalentTo"} +xref: EFO:0001075 {source="DOID:4001", source="MONDO:equivalentTo"} +xref: NCIT:C4908 {source="DOID:4001", source="EFO:0001075", source="MONDO:equivalentTo"} +is_a: MONDO:0018364 {source="DOID:4001", source="MONDO:Redundant", source="NCIT:C4908"} ! malignant epithelial tumor of ovary +property_value: exactMatch DOID:4001 +property_value: exactMatch NCIT:C4908 + +[Term] +id: MONDO:0005144 +name: familial amyotrophic lateral sclerosis +def: "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "hereditary amyotrophic lateral sclerosis" EXACT [MONDO:patterns/hereditary] +xref: EFO:0001356 {source="MONDO:equivalentTo"} +xref: OMIM:205250 {source="Orphanet:803/btnt"} +xref: OMIM:300857 {source="Orphanet:803/btnt"} +xref: OMIM:606070 {source="Orphanet:803/btnt"} +xref: OMIM:606640 {source="Orphanet:803/btnt"} +xref: OMIM:608030 {source="Orphanet:803/btnt"} +xref: OMIM:608031 {source="Orphanet:803/btnt"} +xref: OMIM:608627 {source="Orphanet:803/btnt"} +xref: OMIM:611895 {source="Orphanet:803/btnt"} +xref: OMIM:612069 {source="Orphanet:803/btnt"} +xref: OMIM:612577 {source="Orphanet:803/btnt"} +xref: OMIM:613435 {source="Orphanet:803/btnt"} +xref: OMIM:613954 {source="Orphanet:803/btnt"} +xref: OMIM:614696 {source="Orphanet:803/btnt"} +xref: OMIM:614808 {source="Orphanet:803/btnt"} +xref: OMIM:615426 {source="Orphanet:803/btnt"} +xref: OMIM:615515 {source="Orphanet:803/btnt"} +xref: OMIM:616208 {source="Orphanet:803/btnt"} +xref: OMIM:616437 {source="MONDO:relatedTo", source="Orphanet:803/btnt"} +xref: OMIMPS:105400 {source="MONDO:equivalentTo", source="DOID:332"} +is_a: MONDO:0004976 {source="EFO:0001356", source="MONDO:Redundant"} ! amyotrophic lateral sclerosis +is_a: MONDO:0024257 ! hereditary motor neuron disease +intersection_of: MONDO:0004976 ! amyotrophic lateral sclerosis +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch https://omim.org/phenotypicSeries/PS105400 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005147 +name: type 1 diabetes mellitus +def: "A chronic condition characterized by minimal or absent production of insulin by the pancreas." [NCIT:C2986] +synonym: "diabetes mellitis type 1" EXACT [] +synonym: "diabetes mellitis type I" EXACT [] +synonym: "IDDM" EXACT DEPRECATED [DOID:9744] +synonym: "immune mediated diabetes" EXACT [NCIT:C2986] +synonym: "insulin dependent diabetes" EXACT DEPRECATED [NCIT:C2986] +synonym: "insulin-dependent diabetes mellitus" EXACT DEPRECATED [DOID:9744, Orphanet:243377] +synonym: "juvenile diabetes" EXACT DEPRECATED [NCIT:C2986] +synonym: "type 1 diabetes" EXACT [NCIT:C2986] +synonym: "type I diabetes" EXACT [NCIT:C2986] +synonym: "type I diabetes mellitus" EXACT [DOID:9744] +xref: DOID:9744 {source="MONDO:equivalentTo", source="EFO:0001359"} +xref: EFO:0001359 {source="DOID:9744", source="MONDO:equivalentTo"} +xref: KEGG:04940 {source="DOID:9744", source="MONDO:relatedTo"} +xref: MESH:D003922 {source="DOID:9744", source="MONDO:equivalentTo", source="EFO:0001359"} +xref: NCIT:C2986 {source="DOID:9744", source="MONDO:equivalentTo", source="EFO:0001359"} +xref: OMIM:222100 {source="DOID:9744", source="MONDO:equivalentTo", source="EFO:0001359"} +xref: Orphanet:243377 {source="MONDO:equivalentTo"} +xref: SCTID:46635009 {source="DOID:9744", source="MONDO:equivalentTo", source="EFO:0001359"} +is_a: MONDO:0000569 ! autoimmune disorder of endocrine system +is_a: MONDO:0000588 ! autoimmune disorder of gastrointestinal tract +is_a: MONDO:0005015 {source="DOID:9744", source="EFO:0001359", source="MESH:D003922", source="NCIT:C2986"} ! diabetes mellitus +relationship: disease_arises_from_feature HP:0006476 ! Abnormality of the pancreatic islet cells +relationship: disease_causes_feature MONDO:0012819 ! diabetic ketoacidosis +relationship: disease_has_basis_in_disruption_of GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus +relationship: disease_has_basis_in_dysfunction_of CL:0000169 ! type B pancreatic cell +property_value: exactMatch DOID:9744 +property_value: exactMatch http://identifiers.org/mesh/D003922 +property_value: exactMatch http://identifiers.org/snomedct/46635009 +property_value: exactMatch https://omim.org/entry/222100 +property_value: exactMatch NCIT:C2986 +property_value: exactMatch Orphanet:243377 + +[Term] +id: MONDO:0005148 +name: type 2 diabetes mellitus +def: "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." [NCIT:P378] +synonym: "adult onset diabetes" EXACT DEPRECATED [NCIT:C26747] +synonym: "adult-onset diabetes" EXACT DEPRECATED [NCIT:C26747] +synonym: "diabetes mellitis type 2" EXACT [] +synonym: "diabetes mellitis type II" EXACT [] +synonym: "diabetes mellitus, non-insulin-dependent, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, noninsulin-dependent" EXACT [MONDO:Lexical, OMIM:125853] +synonym: "diabetes mellitus, noninsulin-dependent, 2" NARROW [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, noninsulin-dependent, association with" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, noninsulin-dependent, late onset" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, noninsulin-dependent, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, type 2" EXACT [OMIM:125853] +synonym: "diabetes mellitus, type 2, protection against" RELATED [OMIM:125853] +synonym: "diabetes mellitus, type 2, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, type II" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes mellitus, type II, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "diabetes, type 2" EXACT [NCIT:C26747] +synonym: "hypertension, insulin resistance-related, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "insulin resistance, severe, digenic" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "insulin resistance, susceptibility to" RELATED [OMIM:125853] +synonym: "maturity-onset diabetes" RELATED [OMIM:125853] +synonym: "NIDDM" EXACT DEPRECATED [DOID:9352, MONDO:Lexical, NCIT:C26747, OMIM:125853] +synonym: "non-insulin dependent diabetes" EXACT DEPRECATED [NCIT:C26747] +synonym: "non-insulin dependent diabetes mellitus" EXACT DEPRECATED [NCIT:C26747] +synonym: "non-insulin-dependent diabetes mellitus" EXACT DEPRECATED [DOID:9352] +synonym: "noninsulin dependent diabetes" EXACT DEPRECATED [NCIT:C26747] +synonym: "noninsulin-dependent diabetes mellitus" EXACT [OMIM:125853] +synonym: "T2DM - type 2 diabetes mellitus" EXACT [NCIT:C26747] +synonym: "type 2 diabetes" EXACT [NCIT:C26747] +synonym: "type 2 diabetes mellitus" EXACT [NCIT:C26747] +synonym: "type 2 diabetes mellitus non-insulin dependent" EXACT [NCIT:C26747] +synonym: "type 2 diabetes mellitus, susceptibility to" EXACT [OMIM:125853, OMIM:genemap2] +synonym: "type II diabetes" EXACT [NCIT:C26747] +synonym: "type II diabetes mellitus" EXACT [DOID:9352, NCIT:C26747] +xref: DOID:9352 {source="MONDO:equivalentTo", source="EFO:0001360"} +xref: EFO:0001360 {source="MONDO:equivalentTo", source="DOID:9352"} +xref: KEGG:04930 {source="MONDO:relatedTo", source="DOID:9352"} +xref: MESH:D003924 {source="MONDO:equivalentTo", source="DOID:9352", source="EFO:0001360"} +xref: NCIT:C26747 {source="MONDO:equivalentTo", source="DOID:9352", source="EFO:0001360"} +xref: OMIM:125853 {source="MONDO:equivalentTo", source="DOID:9352", source="EFO:0001360"} +xref: SCTID:44054006 {source="MONDO:equivalentTo", source="DOID:9352", source="EFO:0001360"} +xref: UMLS:CN244395 {source="MONDO:equivalentTo"} +is_a: MONDO:0005015 {source="DOID:9352", source="EFO:0001360", source="MESH:D003924", source="NCIT:C26747"} ! diabetes mellitus +relationship: disease_disrupts GO:0030073 ! insulin secretion +relationship: disease_disrupts GO:0044381 ! glucose import in response to insulin stimulus +relationship: disease_has_feature HP:0000855 ! Insulin resistance +property_value: exactMatch DOID:9352 +property_value: exactMatch http://identifiers.org/mesh/D003924 +property_value: exactMatch http://identifiers.org/snomedct/44054006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN244395 +property_value: exactMatch https://omim.org/entry/125853 +property_value: exactMatch NCIT:C26747 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0005151 +name: endocrine system disorder +def: "A disease involving the endocrine system." [https://orcid.org/0000-0002-6601-2165] +subset: harrisons_view +synonym: "disease of endocrine system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of endocrine system" EXACT [] +synonym: "disorder of endocrine system" EXACT [MONDO:patterns/location_top, NCIT:C3009] +synonym: "endocrine disease" EXACT [DOID:28, NCIT:C3009] +synonym: "endocrine disorder" EXACT [NCIT:C3009] +synonym: "endocrine system disease" EXACT [MONDO:patterns/location] +synonym: "endocrine system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "endocrine system disorder" EXACT [NCIT:C3009] +synonym: "endocrinopathy" EXACT [NCIT:C3009] +synonym: "thyroid or other glandular disorders" EXACT [NCIT:C3009] +xref: DOID:28 {source="EFO:0001379", source="MONDO:equivalentTo"} +xref: EFO:0001379 {source="MONDO:equivalentTo"} +xref: ICD9:259.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:259.9 {source="EFO:0001379", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:28"} +xref: MESH:D004700 {source="EFO:0001379", source="MONDO:equivalentTo", source="DOID:28"} +xref: NCIT:C3009 {source="EFO:0001379", source="MONDO:equivalentTo", source="DOID:28"} +xref: SCTID:362969004 {source="EFO:0001379", source="MONDO:equivalentTo", source="DOID:28"} +xref: UMLS:C0014130 {source="MONDO:equivalentTo", source="DOID:28", source="NCIT:C3009"} +is_a: MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/2741", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000949 ! endocrine system +relationship: disease_has_location UBERON:0000949 ! endocrine system +property_value: exactMatch DOID:28 +property_value: exactMatch http://identifiers.org/mesh/D004700 +property_value: exactMatch http://identifiers.org/snomedct/362969004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014130 +property_value: exactMatch NCIT:C3009 +property_value: excluded_subClassOf MONDO:0021199 {source="DOID:28", source="MONDO:Entailed", source="MONDO:metaclass"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005152 +name: hypopituitarism +def: "A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions." [NCIT:C62591] +subset: gard_rare {source="GARD:0002917"} +synonym: "pituitary hormone deficiency" EXACT [DOID:9406] +synonym: "pituitary hypofunction" RELATED [DOID:9406] +synonym: "pituitary insufficiency" EXACT [DOID:9406] +xref: DOID:9406 {source="MONDO:equivalentTo", source="EFO:0001380"} +xref: EFO:0001380 {source="MONDO:equivalentTo"} +xref: GARD:0002917 {source="MONDO:equivalentTo"} +xref: ICD10CM:E23.0 {source="DOID:9406", source="MONDO:equivalentTo"} +xref: MESH:D007018 {source="DOID:9406", source="MONDO:equivalentTo", source="EFO:0001380"} +xref: NCIT:C62591 {source="DOID:9406", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:0001380"} +xref: SCTID:74728003 {source="DOID:9406", source="MONDO:equivalentTo", source="EFO:0001380"} +xref: UMLS:C0020635 {source="DOID:9406", source="MONDO:equivalentTo", source="NCIT:C62591"} +is_a: MONDO:0003381 {source="DOID:9406", source="MESH:D007018"} ! pituitary gland disorder +property_value: exactMatch DOID:9406 +property_value: exactMatch http://identifiers.org/mesh/D007018 +property_value: exactMatch http://identifiers.org/snomedct/74728003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020635 +property_value: exactMatch https://icd.codes/icd10cm/E23.0 +property_value: exactMatch NCIT:C62591 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/2917/hypopituitarism xsd:anyURI {source="GARD:0002917"} + +[Term] +id: MONDO:0005153 +name: cervical adenocarcinoma +def: "An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type." [NCIT:C4029] +subset: ordo_disease {source="Orphanet:213772"} +synonym: "adenocarcinoma - cervix" EXACT [NCIT:C4029] +synonym: "adenocarcinoma cervix uteri" EXACT [DOID:3702] +synonym: "adenocarcinoma of cervix" EXACT [NCIT:C4029] +synonym: "adenocarcinoma of cervix uteri" EXACT [NCIT:C4029] +synonym: "adenocarcinoma of the cervix" EXACT [NCIT:C4029] +synonym: "adenocarcinoma of the cervix uteri" EXACT [NCIT:C4029] +synonym: "adenocarcinoma of the uterine cervix" EXACT [DOID:3702, NCIT:C4029] +synonym: "adenocarcinoma of uterine cervix" EXACT [NCIT:C4029] +synonym: "cervical adenocarcinoma" EXACT [NCIT:C4029, Orphanet:213772] +synonym: "cervix adenocarcinoma" EXACT [NCIT:C4029] +synonym: "cervix uteri adenocarcinoma" EXACT [NCIT:C4029] +synonym: "uterine cervix adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C4029] +xref: DOID:3702 {source="MONDO:equivalentTo", source="EFO:0001416"} +xref: EFO:0001416 {source="MONDO:equivalentTo"} +xref: ICD10CM:C53.0 {source="Orphanet:213772", source="MONDO:relatedTo", source="Orphanet:213772/btnt"} +xref: ICD10CM:C53.1 {source="Orphanet:213772", source="Orphanet:213772/btnt"} +xref: ICD10CM:C53.8 {source="Orphanet:213772", source="Orphanet:213772/btnt"} +xref: NCIT:C4029 {source="MONDO:equivalentTo", source="DOID:3702", source="EFO:0001416"} +xref: ONCOTREE:CEAD {source="MONDO:equivalentTo"} +xref: Orphanet:213772 {source="MONDO:equivalentTo"} +xref: SCTID:254887002 {source="MONDO:equivalentTo", source="DOID:3702", source="EFO:0001416"} +is_a: MONDO:0004970 {source="EFO:0001416", source="MONDO:0005153/inferred", source="MONDO:Redundant", source="NCIT:C4029"} ! adenocarcinoma +is_a: MONDO:0005131 {source="DOID:3702", source="MONDO:0005153/inferred", source="MONDO:Redundant", source="NCIT:C4029"} ! cervical carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +relationship: has_modifier MONDO:0021136 {source="MONDO:0016274"} ! rare +property_value: broadMatch https://icd.codes/icd10cm/C53.1 +property_value: broadMatch https://icd.codes/icd10cm/C53.8 +property_value: exactMatch DOID:3702 +property_value: exactMatch http://identifiers.org/snomedct/254887002 +property_value: exactMatch NCIT:C4029 +property_value: exactMatch Orphanet:213772 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4897 + +[Term] +id: MONDO:0005154 +name: liver disorder +def: "A disease involving the liver." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of liver" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of liver" EXACT [] +synonym: "disorder of liver" EXACT [MONDO:patterns/location_top] +synonym: "hepatic disease" EXACT [DOID:409] +synonym: "hepatic disorder" EXACT [DOID:409, NCIT:C3196] +synonym: "liver and intrahepatic bile duct disorder" EXACT [NCIT:C3196] +synonym: "liver disease" EXACT [MONDO:patterns/location] +synonym: "liver disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "liver disorder" EXACT [NCIT:C3196] +xref: DOID:409 {source="EFO:0001421", source="MONDO:equivalentTo"} +xref: EFO:0001421 {source="MONDO:equivalentTo"} +xref: ICD10CM:K70-K77 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="DOID:409", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:573.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:573.9 {source="EFO:0001421", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:409"} +xref: MESH:D008107 {source="EFO:0001421", source="MONDO:equivalentTo", source="DOID:409"} +xref: NCIT:C3196 {source="EFO:0001421", source="MONDO:equivalentTo", source="DOID:409"} +xref: NCIT:C50634 {source="EFO:0001421", source="MONDO:otherHierarchy"} +xref: SCTID:235856003 {source="EFO:0001421", source="MONDO:equivalentTo", source="DOID:409"} +xref: UMLS:C0023895 {source="MONDO:equivalentTo", source="DOID:409"} +is_a: MONDO:0002515 {source="DOID:409", source="MONDO:Redundant", source="NCIT:C3196"} ! hepatobiliary disorder +is_a: MONDO:0005151 ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002107 ! liver +relationship: disease_has_location UBERON:0002107 ! liver +property_value: exactMatch DOID:409 +property_value: exactMatch http://identifiers.org/mesh/D008107 +property_value: exactMatch http://identifiers.org/snomedct/235856003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023895 +property_value: exactMatch https://icd.codes/icd10cm/K70-K77 +property_value: exactMatch NCIT:C3196 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: relatedMatch NCIT:C50634 + +[Term] +id: MONDO:0005156 +name: encephalomyelitis +def: "Inflammation of the brain and the spinal cord." [NCIT:P378] +synonym: "central nervous system inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "encephalitis &/or myelitis" EXACT [DOID:640] +synonym: "encephalitis and/or myelitis" EXACT [DOID:640] +synonym: "inflammation of central nervous system" EXACT [] +xref: DOID:640 {source="EFO:0001423", source="MONDO:equivalentTo"} +xref: EFO:0001423 {source="MONDO:equivalentTo"} +xref: ICD9:323.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D004679 {source="EFO:0001423", source="MONDO:equivalentTo", source="DOID:640"} +xref: NCIT:C34580 {source="EFO:0001423", source="MONDO:equivalentTo", source="DOID:640"} +xref: SCTID:62950007 {source="EFO:0001423", source="MONDO:equivalentTo", source="DOID:640"} +xref: UMLS:C0014070 {source="NCIT:C34580", source="MONDO:equivalentTo", source="DOID:640"} +is_a: MONDO:0002602 {source="DOID:640", source="MESH:D004679", source="MESH:D004679/inferred", source="MONDO:Redundant", source="NCIT:C34580/inferred"} ! central nervous system disorder +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C34580/inferred"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001017 ! central nervous system +relationship: disease_has_inflammation_site UBERON:0001017 ! central nervous system +property_value: exactMatch DOID:640 +property_value: exactMatch http://identifiers.org/mesh/D004679 +property_value: exactMatch http://identifiers.org/snomedct/62950007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014070 +property_value: exactMatch NCIT:C34580 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005157 +name: lymphoid neoplasm +def: "A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms." [NCIT:C7065] +synonym: "lymphocytic and plasma cell neoplasm" EXACT [NCIT:C7065] +synonym: "lymphocytic and plasma cell tumor" EXACT [NCIT:C7065] +synonym: "lymphocytic and plasma cell tumour" EXACT [NCIT:C7065] +synonym: "lymphocytic and plasmacytic neoplasm" EXACT [NCIT:C7065] +synonym: "lymphocytic neoplasm" EXACT [NCIT:C7065] +synonym: "lymphocytic tumor" EXACT [NCIT:C7065] +synonym: "lymphoid and plasma cell tumor" EXACT [NCIT:C7065] +synonym: "lymphoid and plasma cell tumour" EXACT [NCIT:C7065] +synonym: "lymphoid and plasmacytic neoplasm" EXACT [NCIT:C7065] +synonym: "lymphoid and plasmacytic tumor" EXACT [NCIT:C7065] +synonym: "lymphoid and plasmacytic tumour" EXACT [NCIT:C7065] +synonym: "lymphoid neoplasm" EXACT [NCIT:C7065] +synonym: "lymphoid tumor" EXACT [NCIT:C7065] +xref: EFO:0001642 {source="MONDO:equivalentTo"} +xref: ICD9:200.7 {source="EFO:0001642"} +xref: NCIT:C7065 {source="MONDO:equivalentTo", source="EFO:0001642"} +xref: ONCOTREE:LYMPH {source="MONDO:equivalentTo"} +xref: UMLS:C0598798 {source="NCIT:C7065", source="MONDO:equivalentTo"} +is_a: MONDO:0044881 {source="NCIT:C7065"} ! hematopoietic and lymphoid cell neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0598798 +property_value: exactMatch NCIT:C7065 + +[Term] +id: MONDO:0005159 +name: prostate carcinoma +def: "A carcinoma that arises from epithelial cells of the prostate gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of prostate" NARROW [NCIT:C4863] +synonym: "cancer of the prostate" NARROW [NCIT:C4863] +synonym: "carcinoma of prostate" EXACT [NCIT:C4863] +synonym: "carcinoma of prostate gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the prostate" EXACT [NCIT:C4863] +synonym: "prostate cancer" NARROW [NCIT:C4863] +synonym: "prostate cancer, NOS" NARROW [NCIT:C4863] +synonym: "prostate carcinoma" EXACT [NCIT:C4863] +synonym: "prostate gland carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:10286 {source="EFO:0001663", source="MONDO:equivalentTo"} +xref: EFO:0001663 {source="MONDO:equivalentTo", source="DOID:10286"} +xref: KEGG:05215 {source="MONDO:relatedTo", source="DOID:10286"} +xref: NCIT:C4863 {source="EFO:0001663", source="MONDO:equivalentTo", source="DOID:10286"} +xref: UMLS:C0600139 {source="MONDO:equivalentTo", source="NCIT:C4863", source="DOID:10286"} +is_a: MONDO:0004993 {source="DOID:10286", source="EFO:0001663", source="MONDO:Redundant", source="NCIT:C4863"} ! carcinoma +is_a: MONDO:0008315 {source="DOID:10286", source="MONDO:Redundant", source="NCIT:C4863"} ! prostate cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:10286 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0600139 +property_value: exactMatch NCIT:C4863 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005165 +name: benign neoplasm +def: "A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites." [NCIT:C3677] +comment: Editor note: see https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/14 +synonym: "benign neoplasm" EXACT [NCIT:C3677] +synonym: "benign neoplasm (disease)" EXACT [] +synonym: "benign tumor" RELATED [NCIT:C3677] +synonym: "benign unclassifiable tumor" RELATED [NCIT:C3677] +synonym: "cell type benign neoplasm" RELATED [DOID:0060084] +synonym: "neoplasm (disease), benign" EXACT [MONDO:patterns/benign] +synonym: "neoplasm, benign" RELATED [NCIT:C3677] +synonym: "organ system benign neoplasm" RELATED [DOID:0060085] +xref: DOID:0060072 {source="EFO:0002422", source="MONDO:equivalentTo"} +xref: DOID:0060084 {source="MONDO:equivalentTo"} +xref: DOID:0060085 {source="MONDO:equivalentTo"} +xref: EFO:0002422 {source="MONDO:equivalentTo"} +xref: ICD10CM:D10-D36 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10WHO:D10-D36 {source="MONDO:equivalentTo"} +xref: ICD9:210-229.99 {source="EFO:0002422"} +xref: ICD9:229.8 {source="MONDO:i2s"} +xref: ICD9:229.9 {source="MONDO:i2s"} +xref: ICDO:8000/0 {source="NCIT:C3677"} +xref: NCIT:C3677 {source="EFO:0002422", source="MONDO:equivalentTo"} +xref: SCTID:20376005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="DOID:0060072", source="DOID:0060084/inferred", source="DOID:0060085/inferred", source="EFO:0002422", source="ICD10CM:D10-D36", source="MONDO:Redundant", source="NCIT:C3677/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +relationship: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:0060072 +property_value: exactMatch DOID:0060084 +property_value: exactMatch DOID:0060085 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/D10-D36 +property_value: exactMatch http://identifiers.org/snomedct/20376005 +property_value: exactMatch https://icd.codes/icd10cm/D10-D36 +property_value: exactMatch NCIT:C3677 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0005170 +name: myeloid neoplasm +def: "Proliferation of myeloid cells originating from a primitive stem cell." [NCIT:C9290] +synonym: "myeloid malignancy" EXACT [NCIT:C9290] +synonym: "myeloid neoplasm" EXACT [NCIT:C9290] +synonym: "myeloid tumor" EXACT [NCIT:C9290] +xref: DOID:0070004 {source="MONDO:equivalentTo"} +xref: EFO:0002427 {source="MONDO:equivalentTo"} +xref: ICDO:9975/1 {source="NCIT:C9290"} +xref: NCIT:C9290 {source="MONDO:equivalentTo", source="EFO:0002427"} +xref: ONCOTREE:MYELOID {source="MONDO:equivalentTo"} +xref: UMLS:C2939461 {source="MONDO:equivalentTo", source="NCIT:C9290"} +is_a: MONDO:0044881 {source="NCIT:C9290"} ! hematopoietic and lymphoid cell neoplasm +relationship: disease_arises_from_structure UBERON:0012429 {source="NCIT:C9290"} ! hematopoietic tissue +property_value: exactMatch DOID:0070004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2939461 +property_value: exactMatch NCIT:C9290 +property_value: excluded_subClassOf MONDO:0005157 {source="EFO:0002427"} + +[Term] +id: MONDO:0005172 +name: skeletal system disorder +def: "A disease involving the skeletal system." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of bone and/or joint" RELATED [] +synonym: "disease of skeletal system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of skeletal system" EXACT [] +synonym: "disorder of skeletal system" EXACT [MONDO:patterns/location_top] +synonym: "osteoarthropathy" RELATED [] +synonym: "skeletal system disease" EXACT [MONDO:patterns/location] +synonym: "skeletal system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: EFO:0002461 {source="MONDO:equivalentTo"} +xref: SCTID:88230002 {source="MONDO:equivalentTo"} +xref: UMLS:C0263661 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 {source="MONDO:Redundant"} ! musculoskeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001434 ! skeletal system +relationship: disease_has_location UBERON:0001434 ! skeletal system +property_value: exactMatch http://identifiers.org/snomedct/88230002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0263661 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005178 +name: osteoarthritis +def: "A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity." [NCIT:C3293] +synonym: "degenerative arthritis" EXACT [DOID:8398] +synonym: "degenerative joint disease" EXACT [DOID:8398] +synonym: "hypertrophic arthritis" EXACT [DOID:8398] +synonym: "osteoarthrosis" EXACT [DOID:8398] +synonym: "osteoarthrosis and allied disorder" EXACT [DOID:8398] +xref: DOID:8398 {source="MONDO:equivalentTo", source="EFO:0002506"} +xref: EFO:0002506 {source="MONDO:equivalentTo", source="DOID:8398"} +xref: GARD:0011929 {source="MONDO:equivalentTo"} +xref: HP:0002758 {source="MONDO:otherHierarchy", source="EFO:0002506"} +xref: ICD10CM:M15-M19 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10CM:M19 {source="MONDO:equivalentTo"} +xref: ICD9:715.3 {source="DOID:8398"} +xref: MESH:D010003 {source="MONDO:equivalentTo", source="EFO:0002506"} +xref: NCIT:C3293 {source="MONDO:equivalentTo", source="EFO:0002506"} +xref: SCTID:396275006 {source="MONDO:equivalentTo", source="EFO:0002506"} +xref: UMLS:C0029408 {source="NCIT:C3293", source="MONDO:equivalentTo"} +is_a: MONDO:0005578 {source="DOID:8398", source="EFO:0002506", source="MESH:D010003", source="MONDO:Redundant", source="NCIT:C3293"} ! arthritic joint disease +relationship: disease_has_feature HP:0001369 ! Arthritis +property_value: exactMatch DOID:8398 +property_value: exactMatch http://identifiers.org/mesh/D010003 +property_value: exactMatch http://identifiers.org/snomedct/396275006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029408 +property_value: exactMatch https://icd.codes/icd10cm/M15-M19 +property_value: exactMatch https://icd.codes/icd10cm/M19 +property_value: exactMatch NCIT:C3293 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/1395 xsd:string + +[Term] +id: MONDO:0005180 +name: Parkinson disease +def: "A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression." [NCIT:P378] +synonym: "paralysis agitans" EXACT [DOID:14330] +synonym: "Parkinson disease" EXACT [] +synonym: "Parkinson's disease" EXACT [DOID:14330, ISBN-13:978-1-259-64403-0] +xref: DOID:14330 {source="MONDO:equivalentTo", source="EFO:0002508"} +xref: EFO:0002508 {source="MONDO:equivalentTo", source="DOID:14330"} +xref: ICD9:332 {source="DOID:14330", source="EFO:0002508"} +xref: ICD9:332.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14330"} +xref: KEGG:05012 {source="MONDO:relatedTo", source="DOID:14330"} +xref: MESH:D010300 {source="MONDO:equivalentTo", source="DOID:14330", source="EFO:0002508"} +xref: NCIT:C26845 {source="MONDO:equivalentTo", source="DOID:14330", source="EFO:0002508"} +xref: NIFSTD:birnlex_2098 {source="EFO:0002508"} +xref: OMIMPS:168600 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: Orphanet:319705 {source="MONDO:equivalentTo"} +xref: SCTID:49049000 {source="MONDO:equivalentTo", source="DOID:14330", source="EFO:0002508"} +xref: UMLS:C0030567 {source="MONDO:equivalentTo", source="DOID:14330", source="NCIT:C26845"} +is_a: MONDO:0000510 {source="DOID:14330"} ! synucleinopathy +is_a: MONDO:0021095 {source="MESH:D010300"} ! parkinsonian disorder +property_value: exactMatch DOID:14330 +property_value: exactMatch http://identifiers.org/mesh/D010300 +property_value: exactMatch http://identifiers.org/snomedct/49049000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030567 +property_value: exactMatch https://omim.org/phenotypicSeries/PS168600 +property_value: exactMatch NCIT:C26845 +property_value: exactMatch Orphanet:319705 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005184 +name: pancreatic ductal adenocarcinoma +def: "An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor." [NCIT:C9120] +synonym: "ductal adenocarcinoma of pancreas" EXACT [NCIT:C9120] +synonym: "ductal adenocarcinoma of the pancreas" EXACT [DOID:3498, NCIT:C9120] +synonym: "malignant neoplasm of duct of Wirsung" EXACT [DOID:3587] +synonym: "pancreas ductal adenocarcinoma" EXACT [NCIT:C9120] +synonym: "pancreatic duct adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "pancreatic duct cancer" EXACT [DOID:3587] +synonym: "pancreatic ductal adenocarcinoma" EXACT [NCIT:C9120] +synonym: "pancreatic ductal carcinoma" EXACT [MONDO:0002699] +synonym: "pancreatic tubular adenocarcinoma" RELATED [NCIT:C9120] +xref: DOID:3498 {source="MONDO:equivalentTo", source="EFO:0002517"} +xref: DOID:3587 {source="MONDO:equivalentTo", source="EFO:0002517"} +xref: EFO:0002517 {source="MONDO:equivalentTo"} +xref: ICD9:157.3 {source="DOID:3587"} +xref: MESH:D021441 {source="DOID:3587", source="MONDO:equivalentTo"} +xref: NCIT:C9120 {source="DOID:3498", source="MONDO:equivalentTo", source="EFO:0002517"} +xref: UMLS:C0887833 {source="DOID:3587", source="MONDO:equivalentTo"} +xref: UMLS:C1335302 {source="DOID:3498", source="MONDO:equivalentTo", source="NCIT:C9120"} +is_a: MONDO:0006047 {source="DOID:3498", source="MONDO:Redundant", source="NCIT:C9120"} ! pancreatic adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0007329 ! pancreatic duct +relationship: disease_has_location UBERON:0007329 ! pancreatic duct +property_value: exactMatch DOID:3498 +property_value: exactMatch DOID:3587 +property_value: exactMatch http://identifiers.org/mesh/D021441 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0887833 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335302 +property_value: exactMatch NCIT:C9120 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005186 +name: cocaine dependence +def: "A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance." [NCIT:P378] +synonym: "cocaine addiction" EXACT [NCIT:C34492] +xref: DOID:9975 {source="MONDO:equivalentTo", source="EFO:0002610"} +xref: EFO:0002610 {source="MONDO:equivalentTo"} +xref: ICD9:304.2 {source="DOID:9975", source="EFO:0002610"} +xref: ICD9:304.20 {source="DOID:9975", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C34492 {source="DOID:9975", source="MONDO:equivalentTo", source="EFO:0002610"} +xref: SCTID:31956009 {source="DOID:9975", source="MONDO:equivalentTo", source="EFO:0002610"} +is_a: MONDO:0005303 {source="DOID:9975", source="EFO:0002610", source="MONDO:Redundant", source="NCIT:C34492"} ! drug dependence +intersection_of: MONDO:0005303 ! drug dependence +intersection_of: realized_in_response_to_stimulus CHEBI:27958 ! cocaine +relationship: realized_in_response_to_stimulus CHEBI:27958 ! cocaine +property_value: exactMatch DOID:9975 +property_value: exactMatch http://identifiers.org/snomedct/31956009 +property_value: exactMatch NCIT:C34492 + +[Term] +id: MONDO:0005192 +name: exocrine pancreatic carcinoma +def: "A carcinoma that arises from epithelial cells of the exocrine pancreas" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of pancreas" BROAD [NCIT:C3850] +synonym: "cancer of the pancreas" BROAD [NCIT:C3850] +synonym: "carcinoma of exocrine pancreas" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of pancreas" EXACT [DOID:4905, NCIT:C3850] +synonym: "carcinoma of the pancreas" EXACT [NCIT:C3850] +synonym: "exocrine cancer" BROAD [DOID:4905, NCIT:C3850] +synonym: "exocrine pancreas carcinoma" EXACT [DOID:4905, MONDO:patterns/location, NCIT:C3850] +synonym: "pancreas cancer" BROAD [NCIT:C3850] +synonym: "pancreas carcinoma" EXACT [NCIT:C3850] +synonym: "pancreatic cancer" BROAD [NCIT:C3850] +synonym: "pancreatic cancer (not islets)" EXACT [NCIT:C3850] +synonym: "pancreatic carcinoma" EXACT [NCIT:C3850] +synonym: "pancreatic carcinoma, familial" RELATED [DOID:4905, MESH:C535837] +xref: DOID:4905 {source="MONDO:equivalentTo", source="EFO:0002618"} +xref: EFO:0002618 {source="MONDO:equivalentTo", source="DOID:4905"} +xref: NCIT:C3850 {source="MONDO:equivalentTo", source="DOID:4905", source="EFO:0002618"} +xref: SCTID:372142002 {source="MONDO:equivalentTo", source="DOID:4905", source="EFO:0002618"} +xref: UMLS:C0235974 {source="MONDO:equivalentTo", source="NCIT:C3850", source="DOID:4905"} +is_a: MONDO:0002116 {source="MONDO:Redundant", source="NCIT:C3850"} ! malignant exocrine pancreas neoplasm +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C3850"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000017 ! exocrine pancreas +property_value: exactMatch DOID:4905 +property_value: exactMatch http://identifiers.org/snomedct/372142002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235974 +property_value: exactMatch NCIT:C3850 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005197 +name: thymus neoplasm +def: "A neoplasm that affects the thymus. Representative examples include thymoma and carcinoma." [NCIT:C3412] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:100100"} +synonym: "neoplasm of the Thymus" EXACT [NCIT:C3412] +synonym: "neoplasm of Thymus" EXACT [NCIT:C3412] +synonym: "neoplasm of thymus" EXACT [MONDO:patterns/neoplasm] +synonym: "thymic neoplasm" EXACT [NCIT:C3412] +synonym: "thymic tumor" EXACT [MONDO:0015080, NCIT:C3412] +synonym: "THYMUS" RELATED ABBREVIATION [ONCOTREE:THYMUS] +synonym: "Thymus neoplasm" EXACT [NCIT:C3412] +synonym: "thymus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "Thymus tumor" EXACT [NCIT:C3412] +synonym: "thymus tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Thymus" EXACT [NCIT:C3412] +synonym: "tumor of Thymus" EXACT [NCIT:C3412] +synonym: "tumor of thymus" EXACT [MONDO:patterns/neoplasm] +xref: EFO:0002626 {source="MONDO:equivalentTo"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3412 {source="MONDO:equivalentTo", source="EFO:0002626"} +xref: ONCOTREE:THYMUS {source="MONDO:equivalentTo"} +xref: Orphanet:100100 {source="MONDO:equivalentTo"} +xref: SCTID:127231009 {source="MONDO:equivalentTo"} +xref: UMLS:C3714644 {source="Orphanet:100100", source="MONDO:equivalentTo", source="NCIT:C3412"} +is_a: MONDO:0002082 ! endocrine gland neoplasm +is_a: MONDO:0002334 ! hematopoietic and lymphoid system neoplasm +is_a: MONDO:0003393 ! thymus gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch http://identifiers.org/snomedct/127231009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3714644 +property_value: exactMatch NCIT:C3412 +property_value: exactMatch Orphanet:100100 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005206 +name: renal carcinoma +def: "A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms." [NCIT:C9384] +synonym: "carcinoma of kidney" EXACT [DOID:4451, MONDO:patterns/carcinoma] +synonym: "kidney (including renal cell) cancer" BROAD [NCIT:C9384] +synonym: "kidney (renal) cancer" BROAD [NCIT:C9384] +synonym: "kidney cancer" BROAD [NCIT:C9384] +synonym: "kidney carcinoma" EXACT [DOID:4451, MONDO:patterns/location, NCIT:C9384] +synonym: "renal cancer" BROAD [NCIT:C9384] +synonym: "renal carcinoma" EXACT [NCIT:C9384] +xref: DOID:4451 {source="EFO:0002890", source="MONDO:equivalentTo"} +xref: EFO:0002890 {source="MONDO:equivalentTo"} +xref: NCIT:C9384 {source="EFO:0002890", source="MONDO:equivalentTo", source="DOID:4451"} +xref: UMLS:C1378703 {source="MONDO:equivalentTo", source="DOID:4451", source="NCIT:C9384"} +is_a: MONDO:0002367 {source="DOID:4451", source="MONDO:Redundant", source="NCIT:C9384"} ! kidney cancer +is_a: MONDO:0004993 {source="DOID:4451", source="EFO:0002890", source="MONDO:Redundant", source="NCIT:C9384"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch DOID:4451 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1378703 +property_value: exactMatch NCIT:C9384 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005213 +name: uterine carcinoma +def: "A carcinoma involving a uterus." [MONDO:patterns/carcinoma] +synonym: "carcinoma of uterus" EXACT [MONDO:patterns/carcinoma] +synonym: "uterus carcinoma" EXACT [MONDO:patterns/location] +xref: EFO:0002919 {source="MONDO:equivalentTo"} +xref: SCTID:446022000 {source="MONDO:equivalentTo"} +xref: UMLS:C2960452 {source="MONDO:equivalentTo"} +is_a: MONDO:0002715 ! uterine cancer +is_a: MONDO:0004993 {source="EFO:0002919", source="MONDO:Redundant"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000995 ! uterus +property_value: exactMatch http://identifiers.org/snomedct/446022000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2960452 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005215 +name: vulvar carcinoma +def: "A carcinoma that arises from epithelial cells of the mammalian vulva" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of the vulva" BROAD [NCIT:C4866] +synonym: "cancer of vulva" BROAD [NCIT:C4866] +synonym: "carcinoma of mammalian vulva" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the vulva" EXACT [NCIT:C4866] +synonym: "carcinoma of vulva" EXACT [DOID:1294, NCIT:C4866] +synonym: "mammalian vulva carcinoma" EXACT [MONDO:patterns/location] +synonym: "vulva cancer" BROAD [NCIT:C4866] +synonym: "vulva carcinoma" EXACT [NCIT:C4866] +synonym: "vulvar cancer" BROAD [NCIT:C4866] +synonym: "vulvar carcinoma" EXACT [DOID:1294, NCIT:C4866] +xref: DOID:1294 {source="MONDO:equivalentTo", source="EFO:0002921"} +xref: EFO:0002921 {source="MONDO:equivalentTo"} +xref: NCIT:C4866 {source="MONDO:equivalentTo", source="EFO:0002921", source="DOID:1294"} +xref: Orphanet:494418 {source="MONDO:equivalentTo"} +xref: SCTID:447882007 {source="MONDO:equivalentTo"} +xref: UMLS:C0677055 {source="MONDO:equivalentTo", source="NCIT:C4866", source="DOID:1294"} +is_a: MONDO:0001528 {source="DOID:1294", source="MONDO:Redundant", source="NCIT:C4866"} ! vulva cancer +is_a: MONDO:0004993 {source="DOID:1294", source="EFO:0002921", source="MONDO:Redundant", source="NCIT:C4866"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:1294 +property_value: exactMatch http://identifiers.org/snomedct/447882007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0677055 +property_value: exactMatch NCIT:C4866 +property_value: exactMatch Orphanet:494418 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005216 +name: hypopharyngeal carcinoma +def: "Carcinoma, predominantly squamous cell, arising from the epithelial cells of the hypopharynx." [NCIT:C9465] +comment: Carcinoma, predominantly squamous cell, arising from epithelial cells of the hypopharynx {source="EFO:0002938"} +synonym: "cancer of hypopharynx" BROAD [NCIT:C9465] +synonym: "cancer of the hypopharynx" BROAD [NCIT:C9465] +synonym: "carcinoma of hypopharynx" EXACT [MONDO:patterns/carcinoma, NCIT:C9465] +synonym: "carcinoma of the hypopharynx" EXACT [NCIT:C9465] +synonym: "hypopharyngeal cancer" BROAD [NCIT:C9465] +synonym: "hypopharyngeal carcinoma" EXACT [NCIT:C9465] +synonym: "hypopharyngeal throat cancer" BROAD [NCIT:C9465] +synonym: "hypopharynx carcinoma" EXACT [MONDO:patterns/location] +xref: EFO:0002938 {source="MONDO:equivalentTo"} +xref: NCIT:C9465 {source="MONDO:equivalentTo", source="EFO:0002938"} +is_a: MONDO:0002038 ! head and neck carcinoma +is_a: MONDO:0005806 {source="MONDO:Redundant", source="NCIT:C9465"} ! hypopharynx cancer +is_a: MONDO:0021345 {source="MONDO:Redundant", source="NCIT:C9465"} ! carcinoma of pharynx +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001051 ! hypopharynx +property_value: exactMatch NCIT:C9465 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005217 +name: familial cardiomyopathy +def: "An instance of cardiomyopathy that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "hereditary cardiomyopathy" EXACT [MONDO:patterns/hereditary] +xref: EFO:0002945 {source="MONDO:equivalentTo"} +xref: ICD9:425.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:35728003 {source="MONDO:equivalentTo", source="EFO:0002945"} +xref: UMLS:C0264789 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0004994 {source="EFO:0002945", source="MONDO:Redundant"} ! cardiomyopathy +intersection_of: MONDO:0004994 ! cardiomyopathy +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/35728003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264789 + +[Term] +id: MONDO:0005218 +name: muscular disorder +def: "Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle." [MESH:D009135] +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: obsoletion_candidate +synonym: "disease of muscle organ" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of muscle organ" EXACT [] +synonym: "disorder of muscle organ" EXACT [MONDO:patterns/location_top] +synonym: "muscle organ disease" EXACT [MONDO:patterns/location] +synonym: "muscle organ disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:0080000 {source="EFO:0002970", source="MONDO:equivalentTo"} +xref: EFO:0002970 {source="MONDO:equivalentTo"} +xref: MESH:D009135 {source="EFO:0002970", source="MONDO:equivalentTo"} +is_a: MONDO:0002081 {source="MONDO:cjm"} ! musculoskeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001630 ! muscle organ +relationship: disease_has_location UBERON:0001630 ! muscle organ +property_value: exactMatch DOID:0080000 +property_value: exactMatch http://identifiers.org/mesh/D009135 +property_value: excluded_subClassOf MONDO:0005172 {source="EFO:0002970"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0005220 +name: collecting duct carcinoma +def: "A carcinoma that arises from epithelial cells of the collecting duct of renal tubule" [https://orcid.org/0000-0002-6601-2165] +subset: ordo_disease {source="Orphanet:247203"} +synonym: "BDC" EXACT ABBREVIATION [NCIT:C6194, Orphanet:247203] +synonym: "Bellini carcinoma" EXACT [Orphanet:247203] +synonym: "Bellini duct carcinoma" EXACT [NCIT:C6194, Orphanet:247203] +synonym: "Bellini’s duct carcinoma" RELATED [GARD:0009573] +synonym: "carcinoma of collecting duct of renal tubule" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of collecting ducts of Bellini" EXACT [NCIT:C6194] +synonym: "carcinoma of kidney collecting duct" EXACT [NCIT:C6194] +synonym: "carcinoma of renal collecting duct" EXACT [DOID:4464, NCIT:C6194] +synonym: "carcinoma of the collecting ducts of Bellini" EXACT [NCIT:C6194] +synonym: "carcinoma of the kidney collecting duct" EXACT [NCIT:C6194] +synonym: "carcinoma of the renal collecting duct" EXACT [NCIT:C6194] +synonym: "cDC" EXACT [Orphanet:247203] +synonym: "collecting duct carcinoma" EXACT [NCIT:C6194] +synonym: "collecting duct carcinoma of the kidney" RELATED [GARD:0009573] +synonym: "collecting duct of renal tubule carcinoma" EXACT [MONDO:patterns/location] +synonym: "collecting duct renal cancer" EXACT [NCIT:C6194] +synonym: "collecting duct renal cell carcinoma" EXACT [NCIT:C6194] +synonym: "kidney collecting duct carcinoma" EXACT [NCIT:C6194] +synonym: "renal carcinoma, collecting duct type" EXACT [DOID:4464] +synonym: "renal collecting duct carcinoma" EXACT [NCIT:C6194] +synonym: "renal medullary carcinoma" RELATED [DOID:4464, NCIT:C7572] +xref: DOID:4464 {source="EFO:0003016", source="MONDO:equivalentTo"} +xref: EFO:0003016 {source="MONDO:equivalentTo"} +xref: GARD:0009573 {source="MONDO:equivalentTo"} +xref: ICD10CM:C64 {source="Orphanet:247203/ntbt", source="Orphanet:247203"} +xref: ICDO:8319/3 {source="NCIT:C6194"} +xref: NCIT:C6194 {source="DOID:4464", source="EFO:0003016", source="MONDO:equivalentTo"} +xref: ONCOTREE:CDRCC {source="MONDO:equivalentTo"} +xref: Orphanet:247203 {source="MONDO:equivalentTo"} +xref: UMLS:C1266044 {source="DOID:4464", source="Orphanet:247203", source="MONDO:equivalentTo", source="Orphanet:247203/e", source="NCIT:C6194"} +is_a: MONDO:0005086 {source="DOID:4464", source="EFO:0003016", source="ONCOTREE:CDRCC/inferred", source="Orphanet:247203"} ! renal cell carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001232 ! collecting duct of renal tubule +relationship: disease_has_location UBERON:0001232 ! collecting duct of renal tubule +property_value: exactMatch DOID:4464 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1266044 +property_value: exactMatch NCIT:C6194 +property_value: exactMatch Orphanet:247203 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C64 + +[Term] +id: MONDO:0005221 +name: renal pelvis urothelial carcinoma +def: "A carcinoma that arises from the transitional epithelium of the renal pelvis. It is associated with tobacco use and usually presents with gross or microscopic hematuria. Urothelial carcinomas of the renal pelvis are usually of higher grade and higher stage compared to bladder urothelial carcinomas." [NCIT:C7355] +synonym: "kidney renal pelvis urothelial cancer" EXACT [NCIT:C7355] +synonym: "renal pelvis transitional cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C7355] +synonym: "renal pelvis urothelial cancer" EXACT [NCIT:C7355] +synonym: "renal pelvis urothelial carcinoma" EXACT [NCIT:C7355] +synonym: "transitional cell carcinoma of renal pelvis" EXACT [NCIT:C7355] +synonym: "transitional cell carcinoma of the renal pelvis" EXACT [NCIT:C7355] +synonym: "urothelial cell carcinoma of renal pelvis" EXACT [DOID:5974, NCIT:C7355] +synonym: "urothelial cell carcinoma of the renal pelvis" EXACT [NCIT:C7355] +xref: DOID:5974 {source="MONDO:equivalentTo", source="EFO:0003017"} +xref: EFO:0003017 {source="MONDO:equivalentTo"} +xref: ICD9:189.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C7355 {source="DOID:5974", source="MONDO:equivalentTo", source="EFO:0003017"} +xref: SCTID:408642003 {source="MONDO:equivalentTo", source="EFO:0003017"} +xref: UMLS:C0238410 {source="MONDO:equivalentObsolete", source="DOID:5974", source="NCIT:C7355"} +is_a: MONDO:0005519 {source="DOID:5974", source="MONDO:Redundant", source="NCIT:C7355"} ! renal pelvis carcinoma +is_a: MONDO:0020654 ! renal pelvis/ureter urothelial carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:5974 +property_value: exactMatch http://identifiers.org/snomedct/408642003 +property_value: exactMatch NCIT:C7355 + +[Term] +id: MONDO:0005233 +name: non-small cell lung carcinoma +def: "A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy." [NCIT:P378] +synonym: "non-small cell cancer of lung" EXACT [NCIT:C2926] +synonym: "non-small cell cancer of the lung" EXACT [NCIT:C2926] +synonym: "non-small cell carcinoma of lung" EXACT [NCIT:C2926] +synonym: "non-small cell carcinoma of the lung" EXACT [NCIT:C2926] +synonym: "non-small cell lung cancer" EXACT [DOID:3908, NCIT:C2926] +synonym: "non-small cell lung carcinoma" EXACT [MONDO:ambiguous, NCIT:C2926] +synonym: "non-small cell lung carcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "NSCLC" EXACT ABBREVIATION [DOID:3908, NCIT:C2926, Orphanet:488201] +synonym: "NSCLC - non-small cell lung cancer" EXACT [NCIT:C2926] +xref: DOID:3908 {source="MONDO:equivalentTo", source="EFO:0003060"} +xref: EFO:0003060 {source="DOID:3908", source="MONDO:equivalentTo"} +xref: HP:0030358 {source="MONDO:otherHierarchy"} +xref: KEGG:05223 {source="DOID:3908", source="MONDO:relatedTo"} +xref: MESH:D002289 {source="DOID:3908", source="MONDO:equivalentTo", source="EFO:0003060"} +xref: NCIT:C2926 {source="DOID:3908", source="MONDO:equivalentTo", source="EFO:0003060"} +xref: ONCOTREE:NSCLC {source="MONDO:equivalentTo"} +xref: Orphanet:488201 {source="MONDO:equivalentTo"} +xref: SCTID:254637007 {source="DOID:3908", source="MONDO:equivalentTo", source="EFO:0003060"} +xref: UMLS:C0007131 {source="DOID:3908", source="NCIT:C2926", source="MONDO:equivalentTo"} +is_a: MONDO:0005138 {source="DOID:3908", source="EFO:0003060", source="NCIT:C2926"} ! lung carcinoma +property_value: exactMatch DOID:3908 +property_value: exactMatch http://identifiers.org/mesh/D002289 +property_value: exactMatch http://identifiers.org/snomedct/254637007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007131 +property_value: exactMatch NCIT:C2926 +property_value: exactMatch Orphanet:488201 +property_value: IAO:0000589 "non-small cell lung carcinoma (disease)" xsd:string + +[Term] +id: MONDO:0005240 +name: kidney disorder +def: "A disease involving the kidney." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of kidney" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of kidney" EXACT [] +synonym: "disorder of kidney" EXACT [MONDO:patterns/location_top] +synonym: "kidney disease" EXACT [MONDO:patterns/location] +synonym: "kidney disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "kidney disorder" EXACT [NCIT:C3149] +synonym: "nephropathy" EXACT [DOID:557] +synonym: "renal disease" EXACT [NCIT:C3149] +synonym: "renal disorder" EXACT [NCIT:C3149] +xref: DOID:557 {source="MONDO:equivalentTo", source="EFO:0003086"} +xref: EFO:0003086 {source="DOID:557", source="MONDO:equivalentTo"} +xref: ICD9:583.81 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D007674 {source="DOID:557", source="MONDO:equivalentTo", source="EFO:0003086"} +xref: NCIT:C3149 {source="DOID:557", source="MONDO:equivalentTo", source="EFO:0003086"} +xref: SCTID:90708001 {source="DOID:557", source="MONDO:equivalentTo", source="EFO:0003086"} +xref: UMLS:C0022658 {source="DOID:557", source="MONDO:equivalentTo"} +is_a: MONDO:0002118 {source="DOID:557", source="MESH:D007674", source="MONDO:Redundant", source="NCIT:C3149"} ! urinary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002113 ! kidney +relationship: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch DOID:557 +property_value: exactMatch http://identifiers.org/mesh/D007674 +property_value: exactMatch http://identifiers.org/snomedct/90708001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022658 +property_value: exactMatch NCIT:C3149 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005244 +name: peripheral neuropathy +def: "A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs." [NCIT:C119734] +comment: Editor note: NCIT draws a distinction between neuropathy and peripheral neuropathy see https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/20 +synonym: "neuropathy" EXACT [MONDO:0005337, NCIT:C4731] +synonym: "peripheral nerve disorder" EXACT [NCIT:C119734] +synonym: "peripheral neuropathy" EXACT [DOID:870, https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/20] +xref: DOID:870 {source="EFO:0004149", source="MONDO:equivalentTo"} +xref: EFO:0003100 {source="MONDO:equivalentTo"} +xref: EFO:0004149 {source="MONDO:equivalentTo"} +xref: MedDRA:10034606 {source="EFO:0003100"} +xref: NCIT:C119734 {source="EFO:0003100", source="MONDO:equivalentTo"} +xref: NCIT:C4731 {source="EFO:0004149", source="MONDO:equivalentTo", source="DOID:870"} +xref: SCTID:386033004 {source="EFO:0004149", source="MONDO:equivalentTo", source="DOID:870"} +xref: UMLS:C0442874 {source="MONDO:equivalentTo", source="NCIT:C4731", source="DOID:870"} +is_a: MONDO:0003620 {source="DOID:870", source="NCIT:C119734", source="NCIT:C119734/inferred", source="NCIT:C4731"} ! peripheral nervous system disorder +is_a: MONDO:0019056 {source="ISBN-13:978-1-259-64403-0"} ! neuromuscular disease +property_value: closeMatch http://identifiers.org/meddra/10034606 +property_value: exactMatch DOID:870 +property_value: exactMatch http://identifiers.org/snomedct/386033004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0442874 +property_value: exactMatch NCIT:C119734 +property_value: exactMatch NCIT:C4731 + +[Term] +id: MONDO:0005246 +name: osteomyelitis +def: "An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria." [NCIT:P378] +synonym: "osteomyelitis" EXACT [MONDO:ambiguous] +synonym: "osteomyelitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1019 {source="EFO:0003102", source="MONDO:equivalentTo"} +xref: EFO:0003102 {source="MONDO:equivalentTo"} +xref: GARD:0007286 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: HP:0002754 {source="MONDO:otherHierarchy"} +xref: ICD9:730.0 {source="EFO:0003102"} +xref: ICD9:730.01 {source="DOID:1019"} +xref: ICD9:730.1 {source="EFO:0003102", source="DOID:1019"} +xref: ICD9:730.10 {source="DOID:1019"} +xref: ICD9:730.11 {source="DOID:1019"} +xref: ICD9:730.20 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:730.28 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:730.92 {source="EFO:0003102"} +xref: ICD9:730.93 {source="EFO:0003102"} +xref: ICD9:730.94 {source="EFO:0003102"} +xref: ICD9:730.96 {source="EFO:0003102"} +xref: ICD9:730.97 {source="EFO:0003102"} +xref: MESH:D010019 {source="EFO:0003102", source="MONDO:equivalentTo"} +xref: NCIT:C27577 {source="EFO:0003102", source="MONDO:equivalentTo"} +xref: SCTID:60168000 {source="EFO:0003102", source="MONDO:equivalentTo"} +xref: UMLS:C0029443 {source="MONDO:equivalentTo", source="NCIT:C27577"} +is_a: MONDO:0002614 {source="DOID:1019"} ! bone inflammation disease +is_a: MONDO:0003225 ! bone marrow disorder +property_value: exactMatch DOID:1019 +property_value: exactMatch http://identifiers.org/mesh/D010019 +property_value: exactMatch http://identifiers.org/snomedct/60168000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029443 +property_value: exactMatch NCIT:C27577 +property_value: excluded_subClassOf MONDO:0005113 {source="EFO:0003102"} +property_value: IAO:0000589 "osteomyelitis (disease)" xsd:string + +[Term] +id: MONDO:0005247 +name: bacterial urinary tract infection +def: "A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine." [NCIT:P378] +synonym: "bacterial urinary tract infection (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "infection, urinary tract" BROAD [NCIT:C50791] +synonym: "tract, infection of urinary" BROAD [NCIT:C50791] +synonym: "urinary tract infection" BROAD [MONDO:ambiguous] +synonym: "urinary tract infection (disease)" BROAD [] +synonym: "urinary tract infectious disease" BROAD [NCIT:C50791] +synonym: "UTI" BROAD ABBREVIATION [NCIT:C50791] +xref: EFO:0003103 {source="MONDO:equivalentTo"} +xref: ICD9:599.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C50791 {source="EFO:0003103", source="MONDO:equivalentTo"} +xref: SCTID:68566005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 {source="EFO:0003103", source="MONDO:Entailed", source="MONDO:Redundant"} ! bacterial infectious disease +is_a: MONDO:0100338 ! urinary tract infection +intersection_of: MONDO:0005113 ! bacterial infectious disease +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch http://identifiers.org/snomedct/68566005 +property_value: exactMatch NCIT:C50791 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: IAO:0000589 "bacterial urinary tract infection (disease)" xsd:string + +[Term] +id: MONDO:0005265 +name: inflammatory bowel disease +def: "A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type." [NCIT:C3138] +synonym: "autoimmune bowel disorder" EXACT [NCIT:C3138] +synonym: "IBD" EXACT ABBREVIATION [NCIT:C3138] +synonym: "inflammatory bowel disease" EXACT [NCIT:C3138] +xref: DOID:0050589 {source="MONDO:equivalentTo", source="EFO:0003767"} +xref: EFO:0003767 {source="MONDO:equivalentTo", source="DOID:0050589"} +xref: ICD9:558.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: KEGG:05321 {source="MONDO:relatedTo", source="DOID:0050589"} +xref: MESH:D015212 {source="MONDO:equivalentTo", source="DOID:0050589", source="EFO:0003767"} +xref: NCIT:C3138 {source="MONDO:equivalentTo", source="DOID:0050589", source="EFO:0003767"} +xref: OMIMPS:266600 {source="MONDO:equivalentTo", source="DOID:0050589"} +xref: SCTID:24526004 {source="MONDO:equivalentTo", source="DOID:0050589", source="EFO:0003767"} +xref: UMLS:C0021390 {source="MONDO:equivalentTo", source="DOID:0050589", source="NCIT:C3138"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005020 {source="DOID:0050589", source="EFO:0003767", source="MESH:D015212", source="NCIT:C3138/inferred"} ! intestinal disorder +is_a: MONDO:0005046 ! immune system disorder +property_value: exactMatch DOID:0050589 +property_value: exactMatch http://identifiers.org/mesh/D015212 +property_value: exactMatch http://identifiers.org/snomedct/24526004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0021390 +property_value: exactMatch https://omim.org/phenotypicSeries/PS266600 +property_value: exactMatch NCIT:C3138 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005266 +name: diabetic retinopathy +def: "A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness." [NCIT:P378] +synonym: "retinal abnormality - diabetes-related" EXACT [DOID:8947] +xref: DOID:8947 {source="EFO:0003770", source="MONDO:equivalentTo"} +xref: EFO:0003770 {source="MONDO:equivalentTo"} +xref: ICD9:362.0 {source="EFO:0003770", source="DOID:8947"} +xref: MESH:D003930 {source="EFO:0003770", source="DOID:8947", source="MONDO:equivalentTo"} +xref: NCIT:C34538 {source="EFO:0003770", source="DOID:8947", source="MONDO:equivalentTo"} +xref: SCTID:4855003 {source="EFO:0003770", source="DOID:8947", source="MONDO:equivalentTo"} +xref: UMLS:C0011884 {source="DOID:8947", source="MONDO:equivalentTo", source="NCIT:C34538"} +is_a: MONDO:0002311 {source="DOID:8947", source="NCIT:C34538"} ! retinal vascular disorder +is_a: MONDO:0005066 {source="EFO:0003770", source="MESH:D003930/inferred"} ! metabolic disease +intersection_of: MONDO:0005283 ! retinal disorder +intersection_of: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +relationship: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +property_value: exactMatch DOID:8947 +property_value: exactMatch http://identifiers.org/mesh/D003930 +property_value: exactMatch http://identifiers.org/snomedct/4855003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011884 +property_value: exactMatch NCIT:C34538 + +[Term] +id: MONDO:0005267 +name: heart disorder +def: "A disease involving the heart and/or pericardium." [https://orcid.org/0000-0002-6601-2165] +synonym: "cardiac disease" EXACT [DOID:114] +synonym: "disease of heart" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of heart" EXACT [] +synonym: "disorder of heart" EXACT [MONDO:patterns/location_top] +synonym: "disorder of heart/pericardium" EXACT [https://github.com/monarch-initiative/mondo/issues/1189] +synonym: "heart disease" EXACT [MONDO:patterns/location, NCIT:C3079] +synonym: "heart disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "heart disorder" EXACT [NCIT:C3079] +synonym: "heart trouble" EXACT [NCIT:C3079] +synonym: "heart/pericardial disease" EXACT [https://github.com/monarch-initiative/mondo/issues/1189] +synonym: "heart/pericardial disease or disorder" EXACT [https://github.com/monarch-initiative/mondo/issues/1189] +synonym: "heart/pericardial disorder" EXACT [https://github.com/monarch-initiative/mondo/issues/1189] +synonym: "heart/pericardial trouble" EXACT [https://github.com/monarch-initiative/mondo/issues/1189] +xref: DOID:114 {source="EFO:0003777", source="MONDO:equivalentTo"} +xref: EFO:0003777 {source="MONDO:equivalentTo"} +xref: ICD9:429.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:429.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:114"} +xref: ICD9:V47.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006331 {source="EFO:0003777", source="MONDO:equivalentTo", source="DOID:114"} +xref: NCIT:C3079 {source="MONDO:equivalentTo", source="DOID:114"} +xref: SCTID:56265001 {source="EFO:0003777", source="MONDO:equivalentTo", source="DOID:114"} +xref: UMLS:C0018799 {source="MONDO:equivalentTo", source="NCIT:C3079", source="DOID:114"} +xref: UMLS:CN236661 {source="MONDO:equivalentTo"} +xref: UMLS:CN239852 {source="MONDO:equivalentTo"} +is_a: MONDO:0004995 {source="DOID:114", source="EFO:0003777", source="MESH:D006331", source="MONDO:Redundant", source="NCIT:C3079"} ! cardiovascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0015410 ! heart plus pericardium +relationship: disease_has_location UBERON:0015410 ! heart plus pericardium +property_value: exactMatch DOID:114 +property_value: exactMatch http://identifiers.org/mesh/D006331 +property_value: exactMatch http://identifiers.org/snomedct/56265001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018799 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236661 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN239852 +property_value: exactMatch NCIT:C3079 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005269 +name: carotid artery disorder +def: "A disease involving the carotid artery segment." [https://orcid.org/0000-0002-6601-2165] +synonym: "carotid artery disorder" EXACT [NCIT:C84476] +synonym: "carotid artery segment disease" EXACT [MONDO:patterns/location] +synonym: "carotid artery segment disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of carotid artery segment" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of carotid artery segment" EXACT [] +synonym: "disorder of carotid artery" EXACT [DOID:3407] +synonym: "disorder of carotid artery segment" EXACT [MONDO:patterns/location_top] +xref: DOID:3407 {source="EFO:0003781", source="MONDO:equivalentTo"} +xref: EFO:0003781 {source="MONDO:equivalentTo"} +xref: ICD9:447.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D002340 {source="EFO:0003781", source="MONDO:equivalentTo", source="DOID:3407"} +xref: NCIT:C84476 {source="EFO:0003781", source="MONDO:equivalentTo", source="DOID:3407"} +xref: SCTID:371160000 {source="MONDO:equivalentTo", source="DOID:3407"} +xref: UMLS:C0007273 {source="MONDO:equivalentTo", source="DOID:3407", source="NCIT:C84476"} +is_a: MONDO:0000473 ! arterial disorder +is_a: MONDO:0011057 {source="DOID:3407", source="MESH:D002340"} ! cerebrovascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0005396 ! carotid artery segment +relationship: disease_has_location UBERON:0005396 ! carotid artery segment +property_value: exactMatch DOID:3407 +property_value: exactMatch http://identifiers.org/mesh/D002340 +property_value: exactMatch http://identifiers.org/snomedct/371160000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007273 +property_value: exactMatch NCIT:C84476 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005271 +name: allergic disease +def: "An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures." [NCIT:C114476] +synonym: "allergic disease or disorder" EXACT [] +synonym: "allergic form of disease or disorder" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic form of immune system disease" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic hypersensitivity disease" RELATED [DOID:1205] +synonym: "allergic reaction" EXACT [NCIT:C114476] +synonym: "allergic response" EXACT [NCIT:C114476] +synonym: "allergy" EXACT [DOID:1205, NCIT:C114476] +synonym: "disorder of type I hypersensitivity" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "hypersensitivity" RELATED [DOID:1205] +synonym: "hypersensitivity reaction type I disease" EXACT [DOID:1205] +synonym: "type I hypersensitivity disease" EXACT [MONDO:design_pattern] +xref: DOID:1205 {source="EFO:0003785", source="MONDO:equivalentTo"} +xref: EFO:0003785 {source="MONDO:equivalentTo"} +xref: ICD9:995.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:V15.09 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006967 {source="EFO:0003785", source="MONDO:equivalentTo", source="DOID:1205"} +xref: NCIT:C114476 {source="EFO:0003785", source="MONDO:equivalentTo"} +xref: SCTID:609328004 {source="MONDO:equivalentTo"} +xref: UMLS:C1527304 {source="MONDO:equivalentTo", source="NCIT:C114476"} +is_a: MONDO:0000605 {source="DOID:1205", source="MONDO:Entailed", source="NCIT:C114476"} ! hypersensitivity reaction disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +disjoint_from: MONDO:0007179 ! autoimmune disease +relationship: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +property_value: exactMatch DOID:1205 +property_value: exactMatch http://identifiers.org/mesh/D006967 +property_value: exactMatch http://identifiers.org/snomedct/609328004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1527304 +property_value: exactMatch NCIT:C114476 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/allergic_form_of_disease.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0005275 +name: lung disorder +def: "A disease involving the lung." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of lung" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lung" EXACT [] +synonym: "disorder of lung" EXACT [MONDO:patterns/location_top] +synonym: "lung disease" EXACT [MONDO:patterns/location] +synonym: "lung disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lung disorder" EXACT [] +synonym: "lung disorders" EXACT [NCIT:C3198] +synonym: "pulmonary disease" EXACT [] +synonym: "pulmonary diseases" EXACT [NCIT:C3198] +synonym: "pulmonary disorder" EXACT [NCIT:C3198] +synonym: "pulmonary disorders" EXACT [NCIT:C3198] +xref: DOID:850 {source="MONDO:equivalentTo", source="EFO:0003818"} +xref: EFO:0003818 {source="MONDO:equivalentTo"} +xref: ICD9:518.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D008171 {source="MONDO:equivalentTo", source="EFO:0003818", source="DOID:850"} +xref: NCIT:C3198 {source="MONDO:equivalentTo", source="DOID:850"} +xref: SCTID:19829001 {source="MONDO:equivalentTo", source="DOID:850"} +is_a: MONDO:0000270 {source="DOID:850", source="MONDO:Redundant"} ! lower respiratory tract disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002048 ! lung +relationship: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch DOID:850 +property_value: exactMatch http://identifiers.org/mesh/D008171 +property_value: exactMatch http://identifiers.org/snomedct/19829001 +property_value: exactMatch NCIT:C3198 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005277 +name: migraine disorder +def: "A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity." [NCIT:C89715] +synonym: "migraine" EXACT [NCIT:C89715] +synonym: "migraine disorder" EXACT [DOID:6364] +synonym: "migraine headache" EXACT [NCIT:C89715] +synonym: "migraine variant" EXACT [DOID:6364] +synonym: "migraine with or without aura" EXACT [DOID:6364] +xref: DOID:6364 {source="EFO:0003821", source="MONDO:equivalentTo"} +xref: EFO:0003821 {source="MONDO:equivalentTo", source="DOID:6364"} +xref: ICD9:346 {source="EFO:0003821", source="DOID:6364"} +xref: ICD9:346.9 {source="DOID:6364"} +xref: MESH:D008881 {source="EFO:0003821", source="MONDO:equivalentTo", source="DOID:6364"} +xref: NCIT:C113482 {source="EFO:0003821", source="MONDO:otherHierarchy"} +xref: NCIT:C89715 {source="EFO:0003821", source="MONDO:equivalentTo", source="DOID:6364"} +is_a: MONDO:0005560 ! brain disorder +is_a: MONDO:0017181 {source="MESH:D008881"} ! hypnic headache +is_a: MONDO:0043218 {source="NCIT:C89715"} ! neurovascular disorder +relationship: disease_has_feature HP:0002013 {source="MONDO:Wikidata"} ! Vomiting +property_value: exactMatch DOID:6364 +property_value: exactMatch http://identifiers.org/mesh/D008881 +property_value: exactMatch NCIT:C89715 +property_value: relatedMatch NCIT:C113482 + +[Term] +id: MONDO:0005280 +name: prostatitis +def: "An infectious or non-infectious inflammatory process affecting the prostate gland." [NCIT:P378] +synonym: "inflammation of prostate gland" EXACT [] +synonym: "prostate gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "prostatitis" EXACT [MONDO:ambiguous] +synonym: "prostatitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:14654 {source="EFO:0003830", source="MONDO:equivalentTo"} +xref: EFO:0003830 {source="MONDO:equivalentTo"} +xref: HP:0000024 {source="MONDO:otherHierarchy"} +xref: ICD9:601 {source="DOID:14654"} +xref: ICD9:601.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:601.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:601.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14654"} +xref: MESH:D011472 {source="EFO:0003830", source="MONDO:equivalentTo", source="DOID:14654"} +xref: NCIT:C26866 {source="EFO:0003830", source="MONDO:equivalentTo", source="DOID:14654"} +xref: SCTID:9713002 {source="EFO:0003830", source="MONDO:equivalentTo", source="DOID:14654"} +xref: UMLS:C0033581 {source="MONDO:equivalentTo", source="NCIT:C26866", source="DOID:14654"} +is_a: MONDO:0003105 {source="DOID:14654", source="MESH:D011472", source="MONDO:Redundant", source="NCIT:C26866/inferred"} ! prostate disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002367 ! prostate gland +relationship: disease_has_inflammation_site UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:14654 +property_value: exactMatch http://identifiers.org/mesh/D011472 +property_value: exactMatch http://identifiers.org/snomedct/9713002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0033581 +property_value: exactMatch NCIT:C26866 +property_value: excluded_subClassOf MONDO:0005113 {source="EFO:0003830"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "prostatitis (disease)" xsd:string + +[Term] +id: MONDO:0005281 +name: gallbladder disorder +def: "A disease involving the gall bladder." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of gall bladder" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of gall bladder" EXACT [] +synonym: "disorder of gall bladder" EXACT [MONDO:patterns/location_top] +synonym: "gall bladder disease" EXACT [MONDO:patterns/location] +synonym: "gall bladder disease or disorder" EXACT [MONDO:patterns/location] +synonym: "Gall bladder disorder" EXACT [NCIT:C34631] +synonym: "gallbladder disorder" EXACT [NCIT:C34631] +xref: DOID:0060262 {source="EFO:0003832", source="MONDO:equivalentTo"} +xref: EFO:0003832 {source="MONDO:equivalentTo"} +xref: ICD10CM:K82 {source="MONDO:equivalentTo"} +xref: ICD9:575.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:575.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:0060262"} +xref: MESH:D005705 {source="EFO:0003832", source="MONDO:equivalentTo", source="DOID:0060262"} +xref: NCIT:C34631 {source="MONDO:equivalentTo", source="DOID:0060262"} +xref: OMIMPS:600803 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: SCTID:39621005 {source="MONDO:equivalentTo", source="DOID:0060262"} +xref: UMLS:C0016977 {source="MONDO:equivalentTo", source="NCIT:C34631", source="DOID:0060262"} +is_a: MONDO:0002515 ! hepatobiliary disorder +is_a: MONDO:0003847 {source="OMIMPS:600803"} ! Mendelian disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +relationship: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:0060262 +property_value: exactMatch http://identifiers.org/mesh/D005705 +property_value: exactMatch http://identifiers.org/snomedct/39621005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0016977 +property_value: exactMatch https://icd.codes/icd10cm/K82 +property_value: exactMatch https://omim.org/phenotypicSeries/PS600803 +property_value: exactMatch NCIT:C34631 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005283 +name: retinal disorder +def: "Any disease or disorder of the retina." [NCIT:C62601] +synonym: "eye disease of retina" EXACT [MONDO:design_pattern] +synonym: "retina eye disease" EXACT [MONDO:patterns/location] +synonym: "retinopathy" EXACT [https://orcid.org/0000-0001-5208-3432] +xref: DOID:5679 {source="MONDO:equivalentTo", source="EFO:0003839"} +xref: EFO:0003839 {source="MONDO:equivalentTo"} +xref: HGNC:8002 {source="EFO:0003839"} +xref: ICD9:362.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:362.9 {source="MONDO:equivalentTo", source="DOID:5679", source="MONDO:i2s"} +xref: MESH:D012164 {source="MONDO:equivalentTo", source="DOID:5679"} +xref: NCIT:C62601 {source="MONDO:equivalentTo", source="DOID:5679", source="EFO:0003839"} +xref: SCTID:29555009 {source="MONDO:equivalentTo", source="DOID:5679"} +xref: UMLS:C0035309 {source="MONDO:equivalentTo", source="DOID:5679"} +is_a: MONDO:0005071 ! nervous system disorder +is_a: MONDO:0005328 {source="DOID:5679", source="EFO:0003839", source="MESH:D012164", source="MONDO:Redundant", source="NCIT:C62601/inferred"} ! eye disorder +intersection_of: MONDO:0005328 ! eye disorder +intersection_of: disease_has_location UBERON:0000966 ! retina +relationship: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch DOID:5679 +property_value: exactMatch http://identifiers.org/mesh/D012164 +property_value: exactMatch http://identifiers.org/snomedct/29555009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035309 +property_value: exactMatch NCIT:C62601 + +[Term] +id: MONDO:0005286 +name: palatal neoplasm +def: "A benign or malignant neoplasm that affects the hard palate, soft palate, or uvula." [NCIT:C4402] +synonym: "neoplasm of palate" EXACT [NCIT:C4402] +synonym: "neoplasm of secondary palate" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the palate" EXACT [NCIT:C4402] +synonym: "palate neoplasm" EXACT [NCIT:C4402] +synonym: "palate tumor" EXACT [NCIT:C4402] +synonym: "secondary palate neoplasm" EXACT [] +synonym: "secondary palate neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "secondary palate tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of palate" EXACT [NCIT:C4402] +synonym: "tumor of secondary palate" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the palate" EXACT [NCIT:C4402] +xref: EFO:0003849 {source="MONDO:equivalentTo"} +xref: MESH:D010157 {source="MONDO:equivalentTo", source="EFO:0003849"} +xref: NCIT:C4402 {source="MONDO:equivalentTo", source="EFO:0003849"} +xref: SCTID:126805009 {source="MONDO:equivalentTo"} +xref: UMLS:C0030215 {source="MONDO:equivalentTo", source="NCIT:C4402"} +is_a: MONDO:0021245 {source="NCIT:C4402"} ! oral cavity neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001716 ! secondary palate +relationship: disease_has_location UBERON:0001716 ! secondary palate +property_value: exactMatch http://identifiers.org/mesh/D010157 +property_value: exactMatch http://identifiers.org/snomedct/126805009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030215 +property_value: exactMatch NCIT:C4402 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005289 +name: paranasal sinus neoplasm +def: "A benign or malignant neoplasm that affects the paranasal sinuses. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:C7488] +synonym: "accessory sinus neoplasm" EXACT [NCIT:C7488] +synonym: "accessory sinus tumor" EXACT [NCIT:C7488] +synonym: "neoplasm of accessory sinus" EXACT [DOID:1350, NCIT:C7488] +synonym: "neoplasm of paranasal sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C7488] +synonym: "neoplasm of the accessory sinus" EXACT [NCIT:C7488] +synonym: "neoplasm of the paranasal sinus" EXACT [NCIT:C7488] +synonym: "paranasal sinus neoplasm" EXACT [MONDO:ambiguous, NCIT:C7488] +synonym: "paranasal sinus neoplasm (disease)" EXACT [https://orcid.org/0000-0002-6601-2165, MONDO:patterns/location] +synonym: "paranasal sinus neoplasms" EXACT [NCIT:C7488] +synonym: "paranasal sinus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C7488] +synonym: "tumor of accessory sinus" EXACT [DOID:1350, NCIT:C7488] +synonym: "tumor of paranasal sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C7488] +synonym: "tumor of the accessory sinus" EXACT [NCIT:C7488] +synonym: "tumor of the paranasal sinus" EXACT [NCIT:C7488] +xref: DOID:1350 {source="MONDO:equivalentTo", source="EFO:0003866"} +xref: EFO:0003866 {source="MONDO:equivalentTo"} +xref: HP:0030072 {source="MONDO:otherHierarchy"} +xref: NCIT:C7488 {source="DOID:1350", source="NCIT:C7488", source="MONDO:equivalentTo", source="EFO:0003866"} +xref: SCTID:126675008 {source="DOID:1350", source="MONDO:equivalentTo"} +xref: UMLS:C0030470 {source="DOID:1350", source="NCIT:C7488", source="MONDO:equivalentTo"} +is_a: MONDO:0001735 {source="DOID:1350", source="MONDO:Redundant", source="NCIT:C7488"} ! paranasal sinus disorder +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch DOID:1350 +property_value: exactMatch http://identifiers.org/snomedct/126675008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030470 +property_value: exactMatch NCIT:C7488 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0000589 "paranasal sinus neoplasm (disease)" xsd:string + +[Term] +id: MONDO:0005292 +name: colitis +def: "Inflammation of the colon." [NCIT:P378] +synonym: "colitis" EXACT [MONDO:ambiguous] +synonym: "colitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "colon inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of colon" EXACT [] +xref: DOID:0060180 {source="EFO:0003872", source="MONDO:equivalentTo"} +xref: EFO:0003872 {source="MONDO:equivalentTo", source="DOID:0060180"} +xref: HP:0002583 {source="MONDO:otherHierarchy"} +xref: ICD9:558.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D003092 {source="EFO:0003872", source="MONDO:equivalentTo", source="DOID:0060180"} +xref: NCIT:C26723 {source="EFO:0003872", source="MONDO:equivalentTo", source="DOID:0060180"} +xref: OMIM:191390 {source="DOID:0060180", source="MONDO:directSiblingOf"} +xref: SCTID:64226004 {source="EFO:0003872", source="MONDO:equivalentTo", source="DOID:0060180"} +xref: UMLS:C0009319 {source="MONDO:equivalentTo", source="DOID:0060180", source="NCIT:C26723"} +is_a: MONDO:0002269 ! gastroenteritis +is_a: MONDO:0003409 {source="MESH:D003092", source="MONDO:Redundant"} ! colonic disorder +is_a: MONDO:0005265 {source="DOID:0060180"} ! inflammatory bowel disease +intersection_of: MONDO:0000001 {source="EFO:0000784"} ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001155 {source="EFO:0000784"} ! colon +relationship: disease_has_inflammation_site UBERON:0001155 ! colon +property_value: exactMatch DOID:0060180 +property_value: exactMatch http://identifiers.org/mesh/D003092 +property_value: exactMatch http://identifiers.org/snomedct/64226004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009319 +property_value: exactMatch NCIT:C26723 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "colitis (disease)" xsd:string + +[Term] +id: MONDO:0005297 +name: urethritis +def: "Inflammation of the urethra." [NCIT:P378] +synonym: "inflammation of urethra" EXACT [] +synonym: "non-gonococcal urethritis" EXACT [DOID:1343, NCIT:C27079] +synonym: "Nongonococcal urethritis" EXACT [DOID:1343] +synonym: "urethra inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "urethritis" EXACT [MONDO:ambiguous, NCIT:C26904] +synonym: "urethritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1343 {source="MONDO:equivalentTo", source="EFO:0003878"} +xref: EFO:0003878 {source="MONDO:equivalentTo"} +xref: HP:0500006 {source="MONDO:otherHierarchy"} +xref: ICD9:099.40 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:597.80 {source="DOID:1343"} +xref: MESH:D014526 {source="DOID:1343", source="MONDO:equivalentTo", source="EFO:0003878"} +xref: NCIT:C26904 {source="DOID:1343", source="MONDO:equivalentTo", source="EFO:0003878"} +xref: SCTID:84619001 {source="MONDO:equivalentTo"} +is_a: MONDO:0004184 {source="DOID:1343", source="MESH:D014526", source="MONDO:Redundant", source="NCIT:C26904/inferred"} ! urethral disorder +is_a: MONDO:0005247 ! bacterial urinary tract infection +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000057 ! urethra +relationship: disease_has_inflammation_site UBERON:0000057 ! urethra +property_value: exactMatch DOID:1343 +property_value: exactMatch http://identifiers.org/mesh/D014526 +property_value: exactMatch http://identifiers.org/snomedct/84619001 +property_value: exactMatch NCIT:C26904 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "urethritis (disease)" xsd:string + +[Term] +id: MONDO:0005300 +name: chronic kidney disease +def: "Impairment of the renal function secondary to chronic kidney damage persisting for three or more months." [NCIT:C80078] +synonym: "chronic kidney disease" EXACT [NCIT:C80078] +synonym: "chronic renal disease" EXACT [DOID:784, NCIT:C80078] +synonym: "chronic renal failure syndrome" NARROW [DOID:784] +synonym: "chronic renal insufficiency" RELATED [NCIT:C80078] +synonym: "CKD" EXACT ABBREVIATION [DOID:784] +synonym: "CKD - chronic kidney disease" EXACT [NCIT:C80078] +synonym: "kidney disease, chronic" EXACT [MONDO:patterns/chronic] +synonym: "renal failure - chronic" EXACT [DOID:784] +xref: DOID:784 {source="EFO:0003884", source="MONDO:equivalentTo"} +xref: EFO:0003884 {source="MONDO:equivalentTo", source="DOID:784"} +xref: ICD10CM:N18.9 {source="MONDO:equivalentTo", source="DOID:784"} +xref: ICD9:585 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:585.6 {source="EFO:0003884", source="DOID:784"} +xref: MESH:D007676 {source="EFO:0003884", source="MONDO:equivalentTo", source="DOID:784"} +xref: NCIT:C80078 {source="EFO:0003884", source="MONDO:equivalentTo"} +xref: SCTID:709044004 {source="MONDO:equivalentTo"} +xref: UMLS:C0022661 {source="MONDO:equivalentTo", source="NCIT:C9438", source="DOID:784"} +is_a: MONDO:0005240 ! kidney disorder +intersection_of: MONDO:0005240 ! kidney disorder +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:784 +property_value: exactMatch http://identifiers.org/mesh/D007676 +property_value: exactMatch http://identifiers.org/snomedct/709044004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022661 +property_value: exactMatch https://icd.codes/icd10cm/N18.9 +property_value: exactMatch NCIT:C80078 + +[Term] +id: MONDO:0005301 +name: multiple sclerosis +def: "A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers." [NCIT:P378] +synonym: "generalized multiple sclerosis" NARROW [DOID:2377] +synonym: "insular sclerosis" RELATED [DOID:2377] +xref: DOID:2377 {source="EFO:0003885", source="MONDO:equivalentTo"} +xref: EFO:0003885 {source="DOID:2377", source="MONDO:equivalentTo"} +xref: ICD10CM:G35 {source="DOID:2377", source="MONDO:equivalentTo"} +xref: ICD9:340 {source="EFO:0003885", source="DOID:2377"} +xref: MESH:D009103 {source="EFO:0003885", source="DOID:2377", source="MONDO:equivalentTo"} +xref: NCIT:C3243 {source="EFO:0003885", source="DOID:2377", source="MONDO:equivalentTo"} +xref: Orphanet:802 {source="MONDO:equivalentTo"} +xref: SCTID:24700007 {source="EFO:0003885", source="DOID:2377", source="MONDO:equivalentTo"} +xref: UMLS:C0026769 {source="DOID:2377", source="MONDO:equivalentTo", source="NCIT:C3243"} +is_a: MONDO:0000568 ! autoimmune disorder of central nervous system +is_a: MONDO:0002562 {source="DOID:2377", source="ICD10CM:G35", source="MESH:D009103/inferred"} ! demyelinating disease +is_a: MONDO:0005560 {source="MESH:D009103/inferred", source="MONDO:Redundant"} ! brain disorder +is_a: MONDO:0006704 {source="MESH:D009103"} ! CNS demyelinating autoimmune disease +property_value: exactMatch DOID:2377 +property_value: exactMatch http://identifiers.org/mesh/D009103 +property_value: exactMatch http://identifiers.org/snomedct/24700007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026769 +property_value: exactMatch https://icd.codes/icd10cm/G35 +property_value: exactMatch NCIT:C3243 +property_value: exactMatch Orphanet:802 + +[Term] +id: MONDO:0005303 +name: drug dependence +def: "Drug dependence - replaced the term \"drug addiction\" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug." [NCIT:P378] +synonym: "chemical dependence" EXACT [NCIT:C3894] +xref: DOID:9974 {source="MONDO:equivalentTo", source="EFO:0003890"} +xref: EFO:0003890 {source="MONDO:equivalentTo"} +xref: ICD9:304 {source="EFO:0003890"} +xref: ICD9:304.6 {source="DOID:9974"} +xref: ICD9:304.60 {source="DOID:9974", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:304.90 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3894 {source="MONDO:equivalentTo", source="EFO:0003890"} +xref: SCTID:191816009 {source="MONDO:equivalentTo", source="EFO:0003890"} +is_a: MONDO:0004938 {source="DOID:9974", source="NCIT:C3894"} ! substance dependence +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch DOID:9974 +property_value: exactMatch http://identifiers.org/snomedct/191816009 +property_value: exactMatch NCIT:C3894 +property_value: excluded_subClassOf MONDO:0005084 {source="EFO:0003890"} + +[Term] +id: MONDO:0005304 +name: biliary tract neoplasm +def: "A neoplasm that involves the biliary tract." [MONDO:patterns/location] +synonym: "biliary tract neoplasm" EXACT [MONDO:ambiguous] +synonym: "biliary tract neoplasm (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "biliary tree neoplasm" EXACT [] +synonym: "biliary tree neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "biliary tree tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of biliary tree" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of extrahepatic bile ducts" EXACT [DOID:0050625] +synonym: "tumor of biliary tree" EXACT [MONDO:patterns/neoplasm] +xref: DOID:0050625 {source="EFO:0003891", source="MONDO:equivalentTo"} +xref: EFO:0003891 {source="MONDO:equivalentTo"} +xref: HP:0100574 {source="MONDO:otherHierarchy"} +xref: ONCOTREE:BILIARYTRACT {source="MONDO:equivalentTo"} +xref: SCTID:126853008 {source="MONDO:equivalentTo"} +is_a: MONDO:0004721 ! liver neoplasm +is_a: MONDO:0004868 ! biliary tract disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001173 ! biliary tree +property_value: exactMatch DOID:0050625 +property_value: exactMatch http://identifiers.org/snomedct/126853008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0000589 "biliary tract neoplasm (disease)" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3673 xsd:string + +[Term] +id: MONDO:0005308 +name: ciliopathy +def: "A genetic disorder of the cellular cilia or the cilia anchoring structures, the basal bodies, or of ciliary function." [http://en.wikipedia.org/wiki/Ciliopathy] +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "ciliopathies" RELATED [GTR:AN0966173] +synonym: "ciliopathy" EXACT [] +xref: DOID:0060340 {source="MONDO:equivalentTo", source="EFO:0003900"} +xref: EFO:0003900 {source="MONDO:equivalentTo"} +xref: GTR:AN0966173 {source="UMLS:CN580792"} +xref: Orphanet:363250 {source="MONDO:equivalentTo"} +xref: UMLS:CN580792 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 {source="DOID:0060340", source="EFO:0003900"} ! Mendelian disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005929 ! cilium +relationship: disease_has_basis_in_dysfunction_of GO:0005929 ! cilium +property_value: exactMatch DOID:0060340 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN580792 +property_value: exactMatch Orphanet:363250 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0005311 +name: atherosclerosis +def: "Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen." [NCIT:C35768] +comment: Note that NCIT distinguishes between atherosclerotic cardiovascular disease and atherosclerosis - we merge these here +synonym: "atherosclerosis artery" RELATED [] +synonym: "atherosclerosis of artery" EXACT [] +synonym: "atherosclerotic cardiovascular disease" EXACT [NCIT:C35771] +xref: DOID:1936 {source="MONDO:equivalentTo", source="EFO:0003914"} +xref: EFO:0003914 {source="MONDO:equivalentTo", source="DOID:1936"} +xref: ICD10CM:I70 {source="MONDO:equivalentTo", source="DOID:1936"} +xref: ICD9:440 {source="EFO:0003914", source="DOID:1936"} +xref: ICD9:440.8 +xref: MESH:D050197 {source="MONDO:equivalentTo", source="EFO:0003914", source="DOID:1936"} +xref: NCIT:C35768 {source="MONDO:equivalentTo", source="EFO:0003914", source="DOID:1936"} +xref: NCIT:C35771 {source="MONDO:equivalentTo", source="DOID:1936"} +xref: SCTID:441574008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002277 {source="DOID:1936", source="DOID:1936/inferred", source="EFO:0003914", source="MESH:D050197", source="NCIT:C35768", source="NCIT:C35771"} ! arteriosclerosis disorder +property_value: exactMatch DOID:1936 +property_value: exactMatch http://identifiers.org/mesh/D050197 +property_value: exactMatch http://identifiers.org/snomedct/441574008 +property_value: exactMatch https://icd.codes/icd10cm/I70 +property_value: exactMatch NCIT:C35768 +property_value: exactMatch NCIT:C35771 + +[Term] +id: MONDO:0005328 +name: eye disorder +def: "A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma." [NCIT:C26767] +synonym: "disease of eye" EXACT [MONDO:patterns/location_top] +synonym: "disease of eyeball" RELATED [] +synonym: "disease of eyeball of camera-type eye" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of eyeball of camera-type eye" EXACT [] +synonym: "disorder of eye" EXACT [MONDO:patterns/location_top] +synonym: "disorder of eye proper" RELATED [] +synonym: "disorder of eyeball" RELATED [] +synonym: "disorder of eyeball of camera-type eye" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disorder of globe" RELATED [] +synonym: "eye disease" EXACT [MONDO:patterns/location, NCIT:C26767] +synonym: "eye disorder" EXACT [NCIT:C26767] +synonym: "eyeball of camera-type eye disease" EXACT [MONDO:design_pattern] +synonym: "eyeball of camera-type eye disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:5614 {source="MONDO:equivalentTo", source="EFO:0003966"} +xref: EFO:0003966 {source="MONDO:equivalentTo"} +xref: ICD9:360 {source="DOID:5614"} +xref: ICD9:360.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:360.9 {source="DOID:5614", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:379.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:379.90 {source="DOID:5614", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D005128 {source="DOID:5614", source="MONDO:equivalentTo"} +xref: NCIT:C26767 {source="DOID:5614", source="MONDO:equivalentTo"} +xref: SCTID:371405004 {source="DOID:5614", source="MONDO:equivalentTo"} +xref: UMLS:C0015397 {source="DOID:5614", source="MONDO:equivalentTo", source="NCIT:C26767"} +is_a: MONDO:0002022 {source="DOID:5614", source="MONDO:Redundant"} ! disorder of orbital region +is_a: MONDO:0024458 ! disorder of visual system +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +relationship: disease_has_location UBERON:0000019 {source="NCIT:C26767"} ! camera-type eye +relationship: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch DOID:5614 +property_value: exactMatch http://identifiers.org/mesh/D005128 +property_value: exactMatch http://identifiers.org/snomedct/371405004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015397 +property_value: exactMatch NCIT:C26767 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005334 +name: hereditary nephritis +def: "A group of inherited conditions characterized initially by hematuria and slowly progressing to renal insufficiency. The most common form is the Alport syndrome (hereditary nephritis with hearing loss) which is caused by mutations in genes for type IV collagen and defective glomerular basement membrane." [EFO:0004128] +synonym: "familial nephritis" RELATED [MESH:D009394] +synonym: "hereditary nephritis" EXACT [MESH:D009394, MONDO:patterns/hereditary] +synonym: "nephritis, familial" RELATED [MESH:D009394] +xref: EFO:0004128 {source="MONDO:equivalentTo"} +xref: MESH:D009394 {source="MONDO:equivalentTo", source="EFO:0004128"} +xref: SCTID:399340005 {source="MONDO:equivalentTo"} +is_a: MONDO:0001166 {source="MESH:D009394", source="MONDO:Entailed", source="MONDO:Redundant"} ! nephritis +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0001166 ! nephritis +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/D009394 +property_value: exactMatch http://identifiers.org/snomedct/399340005 + +[Term] +id: MONDO:0005335 +name: colorectal neoplasm +alt_id: MONDO:0021236 +def: "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." [NCIT:C2956] +synonym: "colorectal neoplasm" EXACT [NCIT:C2956] +synonym: "colorectal tumor" EXACT [NCIT:C2956] +synonym: "colorectum neoplasm" EXACT [] +synonym: "colorectum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "colorectum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "large bowel neoplasm" EXACT [NCIT:C2956] +synonym: "large bowel tumor" EXACT [NCIT:C2956] +synonym: "large intestinal neoplasm" EXACT [NCIT:C2956] +synonym: "large intestine neoplasm" EXACT [NCIT:C2956] +synonym: "large intestine tumor" EXACT [NCIT:C2956] +synonym: "neoplasm of colorectum" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of large bowel" EXACT [NCIT:C2956] +synonym: "neoplasm of the large bowel" EXACT [NCIT:C2956] +synonym: "tumor of colorectum" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of large bowel" EXACT [NCIT:C2956] +synonym: "tumor of the large bowel" EXACT [NCIT:C2956] +xref: EFO:0004142 {source="MONDO:equivalentTo"} +xref: MESH:D015179 {source="MONDO:equivalentTo", source="EFO:0004142"} +xref: NCIT:C2956 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:0004142"} +is_a: MONDO:0021118 {source="MONDO:Redundant", source="NCIT:C2956"} ! intestinal neoplasm +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0005070 {source="EFO:0004142"} ! neoplasm +intersection_of: disease_has_location UBERON:0012652 {source="EFO:0004142"} ! colorectum +relationship: disease_has_location UBERON:0012652 ! colorectum +property_value: exactMatch http://identifiers.org/mesh/D015179 +property_value: exactMatch NCIT:C2956 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005336 +name: myopathy +def: "A disease of the muscle in which the muscle fibers do not function properly. This results in muscular weakness." [Wikipedia:Myopathy] +comment: Editor note: TODO check this, relationship to myotonic disorder/syndrome, also check HP definition +xref: DOID:423 {source="EFO:0004145", source="MONDO:equivalentTo"} +xref: EFO:0004145 {source="MONDO:equivalentTo"} +xref: ICD9:359.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:359.9 {source="DOID:423", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:728.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C101216 {source="EFO:0004145", source="DOID:423", source="MONDO:equivalentTo"} +xref: SCTID:129565002 {source="DOID:423", source="MONDO:equivalentTo"} +xref: UMLS:C0026848 {source="DOID:423", source="MONDO:equivalentTo", source="NCIT:C101216"} +is_a: MONDO:0003939 {source="DOID:423", source="MONDO:Entailed", source="MONDO:Redundant"} ! muscle tissue disorder +intersection_of: MONDO:0003939 ! muscle tissue disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0043292 ! contractile fiber +relationship: disease_has_basis_in_dysfunction_of GO:0043292 ! contractile fiber +relationship: disease_has_feature HP:0003198 ! Myopathy +property_value: exactMatch DOID:423 +property_value: exactMatch http://identifiers.org/snomedct/129565002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026848 +property_value: exactMatch NCIT:C101216 + +[Term] +id: MONDO:0005338 +name: open-angle glaucoma +def: "Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage." [NCIT:P378] +synonym: "glaucoma simplex" EXACT [DOID:1067] +synonym: "glaucoma, primary open angle" EXACT [MONDO:Lexical, OMIM:137760] +synonym: "open angle glaucoma" EXACT [DOID:1067, NCIT:C34641] +synonym: "pigmentary glaucoma" EXACT [DOID:1067, ICD9CM:365.13] +synonym: "POAG" EXACT ABBREVIATION [MONDO:Lexical, OMIM:137760] +synonym: "primary open angle glaucoma" EXACT [OMIM:137760] +synonym: "wide-angle glaucoma" EXACT [DOID:1067] +xref: DOID:1067 {source="EFO:0004190", source="MONDO:equivalentTo"} +xref: EFO:0004190 {source="DOID:1067", source="MONDO:equivalentTo"} +xref: ICD9:365.1 {source="DOID:1067", source="EFO:0004190"} +xref: ICD9:365.10 {source="DOID:1067", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:365.13 {source="DOID:1067", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D005902 {source="DOID:1067", source="EFO:0004190", source="MONDO:equivalentTo"} +xref: NCIT:C34641 {source="DOID:1067", source="MONDO:equivalentTo"} +xref: SCTID:46168003 {source="DOID:1067", source="MONDO:equivalentTo"} +xref: SCTID:84494001 {source="DOID:1067", source="EFO:0004190", source="MONDO:equivalentTo"} +xref: UMLS:C0017612 {source="DOID:1067", source="MONDO:equivalentTo", source="NCIT:C34641"} +is_a: MONDO:0005041 {source="DOID:1067", source="EFO:0004190", source="MESH:D005902", source="NCIT:C34641"} ! glaucoma +property_value: exactMatch DOID:1067 +property_value: exactMatch http://identifiers.org/mesh/D005902 +property_value: exactMatch http://identifiers.org/snomedct/46168003 +property_value: exactMatch http://identifiers.org/snomedct/84494001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017612 +property_value: exactMatch NCIT:C34641 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/2507 xsd:string + +[Term] +id: MONDO:0005341 +name: skin basal cell carcinoma +def: "The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas." [NCIT:C2921] +synonym: "basal cell cancer" BROAD [DOID:2513, NCIT:C2921] +synonym: "basal cell carcinoma" BROAD [NCIT:C2921] +synonym: "basal cell carcinoma of skin" EXACT [DOID:2513, MTH:100, NCIT:C2921] +synonym: "basal cell carcinoma of the skin" EXACT [NCIT:C2921] +synonym: "basal cell epithelioma" EXACT [NCIT:C2921] +synonym: "basal cell skin carcinoma" EXACT [NCIT:C2921] +synonym: "basal cell tumor" BROAD [DOID:2513, NCIT:C3784] +synonym: "BCC" BROAD ABBREVIATION [NCIT:C2921] +synonym: "epithelioma basal cell" RELATED [DOID:2513] +synonym: "skin basal cell cancer" EXACT [NCIT:C2921] +synonym: "skin basal cell carcinoma" EXACT [NCIT:C2921] +xref: CSP:2000-2719 {source="DOID:2513"} +xref: DOID:2513 {source="MONDO:equivalentTo", source="EFO:0004193"} +xref: EFO:0004193 {source="MONDO:equivalentTo", source="DOID:2513"} +xref: HP:0002671 {source="MONDO:otherHierarchy", source="DOID:2513"} +xref: ICDO:8090/3 {source="NCIT:C2921"} +xref: KEGG:05217 {source="MONDO:relatedTo", source="DOID:2513"} +xref: NCIT:C2921 {source="MONDO:equivalentTo", source="DOID:2513", source="EFO:0004193"} +xref: ONCOTREE:BCC {source="MONDO:equivalentTo"} +xref: SCTID:254701007 {source="MONDO:equivalentTo", source="DOID:2513"} +xref: UMLS:C0007117 {source="MONDO:equivalentTo", source="DOID:2513", source="NCIT:C2921"} +xref: UMLS:C0206710 {source="MONDO:equivalentTo", source="DOID:2513"} +xref: UMLS:C0751676 {source="MONDO:equivalentTo"} +is_a: MONDO:0002529 ! skin squamous cell carcinoma +is_a: MONDO:0020804 {source="NCIT:C2921"} ! basal cell carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure CL:0002187 ! basal cell of epidermis +relationship: disease_arises_from_structure CL:0002187 ! basal cell of epidermis +property_value: exactMatch DOID:2513 +property_value: exactMatch http://identifiers.org/snomedct/254701007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007117 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206710 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751676 +property_value: exactMatch NCIT:C2921 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0005359 +name: drug-induced liver injury +def: "A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to acute liver failure, caused by drugs, drug metabolites, and chemicals from the environment." [MESH:D056486] +synonym: "drug induced hepatotoxicity" EXACT [https://orcid.org/0000-0002-8169-9049, OMOP:4144765, SCTID:427399008] +synonym: "drug-induced disorder of liver" EXACT [https://orcid.org/0000-0002-8169-9049, OMOP:4144765, SCTID:427399008] +xref: EFO:0004228 {source="MONDO:equivalentTo"} +xref: MESH:D056486 {source="EFO:0004228", source="MONDO:equivalentTo"} +xref: SCTID:197352008 {source="EFO:0004228", source="MONDO:equivalentTo"} +is_a: MONDO:0005154 {source="EFO:0004228", source="MESH:D056486", source="MONDO:Redundant"} ! liver disorder +intersection_of: MONDO:0005154 ! liver disorder +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch http://identifiers.org/mesh/D056486 +property_value: exactMatch http://identifiers.org/snomedct/197352008 + +[Term] +id: MONDO:0005362 +name: erectile dysfunction +def: "Persistent or recurrent inability to achieve or to maintain an erection during sexual activity." [NCIT:P378] +synonym: "dysfunction, erectile" RELATED [MESH:D007172] +synonym: "erectile dysfunction" EXACT [DOID:1875, MONDO:ambiguous] +synonym: "erectile dysfunction (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "impotence" RELATED [DOID:1875, MESH:D007172] +synonym: "impotence, male" RELATED [MESH:D007172] +synonym: "impotence, male sexual" RELATED [MESH:D007172] +synonym: "male erectile Disorder" EXACT [NCIT:C34801] +synonym: "male impotence" RELATED [MESH:D007172] +synonym: "male sexual impotence" RELATED [MESH:D007172] +synonym: "sexual impotence" EXACT [DOID:1875] +synonym: "sexual impotence (finding)" EXACT [DOID:1875] +synonym: "sexual impotence, Male" RELATED [MESH:D007172] +xref: DOID:1875 {source="EFO:0004234", source="MONDO:equivalentTo"} +xref: EFO:0004234 {source="MONDO:equivalentTo", source="DOID:1875"} +xref: HP:0000802 {source="MONDO:otherHierarchy"} +xref: MESH:D007172 {source="EFO:0004234", source="MONDO:equivalentTo"} +xref: NCIT:C3133 {source="EFO:0004234", source="MONDO:otherHierarchy"} +xref: NCIT:C34801 {source="MONDO:equivalentTo"} +xref: SCTID:397803000 {source="EFO:0004234", source="MONDO:equivalentTo"} +is_a: MONDO:0002036 ! penile disorder +is_a: MONDO:0002134 {source="DOID:1875", source="MESH:D007172"} ! physiological sexual disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0043084 ! penile erection +relationship: disease_disrupts GO:0043084 ! penile erection +property_value: exactMatch DOID:1875 +property_value: exactMatch http://identifiers.org/mesh/D007172 +property_value: exactMatch http://identifiers.org/snomedct/397803000 +property_value: exactMatch NCIT:C34801 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml +property_value: IAO:0000589 "erectile dysfunction (disease)" xsd:string +property_value: relatedMatch NCIT:C3133 + +[Term] +id: MONDO:0005369 +name: carcinoid tumor +def: "A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement." [NCIT:C2915] +comment: Editor note: In NCIT all carcinoid tumors are grade 1, but the name is sometimes used more broadly in other sources +synonym: "carcinoid" EXACT [NCIT:C2915] +synonym: "carcinoid tumor" EXACT [MONDO:ambiguous, NCIT:C2915] +synonym: "carcinoid tumor (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "NET G1" EXACT [MONDO:cjm] +synonym: "neuroendocrine neoplasm G1" EXACT [MONDO:cjm] +synonym: "neuroendocrine tumor G1" EXACT [MONDO:cjm] +xref: EFO:0004243 {source="MONDO:equivalentTo"} +xref: GARD:0009316 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: HP:0100570 {source="MONDO:otherHierarchy"} +xref: ICD9:209.60 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICDO:8240/3 {source="NCIT:C2915"} +xref: ICDO:8241/3 {source="NCIT:C2915"} +xref: MESH:D002276 {source="EFO:0004243", source="MONDO:equivalentTo"} +xref: NCIT:C2915 {source="EFO:0004243", source="MONDO:equivalentTo"} +xref: SCTID:443492008 {source="EFO:0004243", source="MONDO:equivalentTo"} +is_a: MONDO:0019496 {source="MESH:D002276", source="NCIT:C2915"} ! neuroendocrine neoplasm +property_value: exactMatch http://identifiers.org/mesh/D002276 +property_value: exactMatch http://identifiers.org/snomedct/443492008 +property_value: exactMatch NCIT:C2915 +property_value: IAO:0000589 "carcinoid tumor (disease)" xsd:string + +[Term] +id: MONDO:0005371 +name: mood disorder +def: "A cognitive disorder a disturbance in which the person's mood is hypothesized to be the main underlying feature." [Wikipedia:Mood_disorder] +synonym: "episodic mood disorder" NARROW [] +xref: DOID:3324 {source="EFO:0004247", source="MONDO:equivalentTo"} +xref: EFO:0004247 {source="DOID:3324", source="MONDO:equivalentTo"} +xref: ICD10CM:F30-F39 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="DOID:3324", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:296.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D019964 {source="DOID:3324", source="EFO:0004247", source="MONDO:equivalentTo"} +xref: NCIT:C92200 {source="DOID:3324", source="EFO:0004247", source="MONDO:equivalentTo"} +xref: SCTID:46206005 {source="DOID:3324", source="EFO:0004247", source="MONDO:equivalentTo"} +xref: UMLS:CN236678 {source="MONDO:equivalentTo"} +is_a: MONDO:0005084 {source="EFO:0004247", source="ICD10CM:F30-F39"} ! mental disorder +property_value: exactMatch DOID:3324 +property_value: exactMatch http://identifiers.org/mesh/D019964 +property_value: exactMatch http://identifiers.org/snomedct/46206005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236678 +property_value: exactMatch https://icd.codes/icd10cm/F30-F39 +property_value: exactMatch NCIT:C92200 + +[Term] +id: MONDO:0005372 +name: male infertility +def: "The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility." [MESH:D007248] +synonym: "infertility disorder of male reproductive system" EXACT [MONDO:design_pattern] +synonym: "male reproductive system infertility" EXACT [MONDO:patterns/location] +synonym: "male reproductive system infertility disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:12336 {source="EFO:0004248", source="MONDO:equivalentTo"} +xref: EFO:0004248 {source="MONDO:equivalentTo"} +xref: ICD10CM:N46 {source="DOID:12336", source="MONDO:equivalentTo"} +xref: ICD9:606 {source="DOID:12336", source="EFO:0004248", source="MONDO:equivalentTo"} +xref: ICD9:606.9 {source="DOID:12336", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D007248 {source="DOID:12336", source="EFO:0004248", source="MONDO:equivalentTo"} +xref: SCTID:2904007 {source="DOID:12336", source="EFO:0004248", source="MONDO:equivalentTo"} +xref: UMLS:C0021364 {source="DOID:12336", source="MONDO:equivalentTo"} +is_a: MONDO:0003150 {source="DOID:12336", source="ICD10CM:N46", source="MESH:D007248/inferred", source="MONDO:Redundant"} ! male reproductive system disorder +is_a: MONDO:0005047 {source="EFO:0004248", source="MESH:D007248", source="MONDO:Entailed", source="MONDO:Redundant"} ! infertility disorder +intersection_of: MONDO:0005047 ! infertility disorder +intersection_of: disease_has_location UBERON:0000079 ! male reproductive system +property_value: exactMatch DOID:12336 +property_value: exactMatch http://identifiers.org/mesh/D007248 +property_value: exactMatch http://identifiers.org/snomedct/2904007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0021364 +property_value: exactMatch https://icd.codes/icd10cm/N46 + +[Term] +id: MONDO:0005374 +name: bone marrow neoplasm +def: "Neoplasms that affect the bone marrow. Such neoplasms may arise in the bone marrow (e.g. myeloid leukemias) or may involve the bone marrow as secondary, metastatic tumors (e.g. metastatic carcinomas to the bone marrow)." [NCIT:C35370] +synonym: "bone marrow cancer" NARROW [DOID:4960] +synonym: "bone marrow neoplasm" EXACT [DOID:4960, NCIT:C35370] +synonym: "bone marrow neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "bone marrow tumor" EXACT [DOID:4960, MONDO:patterns/neoplasm, NCIT:C35370] +synonym: "malignant bone marrow tumor" NARROW [DOID:4960] +synonym: "neoplasm of bone marrow" EXACT [MONDO:patterns/neoplasm, NCIT:C35370] +synonym: "tumor of bone marrow" EXACT [MONDO:patterns/neoplasm] +xref: DOID:4960 {source="MONDO:equivalentTo"} +xref: ICD9:238.79 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D019046 {source="MONDO:equivalentTo"} +xref: NCIT:C35370 {source="MONDO:equivalentTo"} +xref: SCTID:414824005 {source="MONDO:equivalentTo"} +xref: UMLS:C0282609 {source="NCIT:C35370", source="MONDO:equivalentTo"} +is_a: MONDO:0002334 {source="DOID:4960/inferred", source="MESH:D019046", source="MONDO:Redundant", source="NCIT:C35370"} ! hematopoietic and lymphoid system neoplasm +is_a: MONDO:0003225 {source="DOID:4960", source="MESH:D019046", source="MONDO:Redundant", source="NCIT:C35370"} ! bone marrow disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002371 ! bone marrow +property_value: exactMatch DOID:4960 +property_value: exactMatch http://identifiers.org/mesh/D019046 +property_value: exactMatch http://identifiers.org/snomedct/414824005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0282609 +property_value: exactMatch NCIT:C35370 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005375 +name: nasopharyngeal neoplasm +alt_id: MONDO:0021362 +def: "A benign or malignant neoplasm affecting the nasopharynx. Representative examples of benign neoplasms include angiofibroma and squamous papilloma. Representative examples of malignant neoplasms include keratinizing squamous cell carcinoma and nonkeratinizing carcinoma." [NCIT:C3257] +synonym: "nasopharyngeal neoplasms" EXACT [NCIT:C3257] +synonym: "nasopharyngeal tumor" EXACT [NCIT:C3257] +synonym: "nasopharynx neoplasm" EXACT [] +synonym: "nasopharynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nasopharynx tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of nasopharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3257] +synonym: "neoplasm of the nasopharynx" EXACT [NCIT:C3257] +synonym: "tumor of nasopharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3257] +synonym: "tumor of the nasopharynx" EXACT [NCIT:C3257] +xref: EFO:0004252 {source="MONDO:equivalentTo"} +xref: MESH:D009303 {source="MONDO:equivalentTo", source="EFO:0004252"} +xref: NCIT:C3257 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:0004252"} +xref: SCTID:126680004 {source="MONDO:equivalentTo"} +xref: UMLS:C0027439 {source="MONDO:equivalentTo", source="NCIT:C3257"} +is_a: MONDO:0004821 {source="MESH:D009303", source="MONDO:Redundant", source="NCIT:C3257"} ! nasopharyngeal disorder +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0020641 ! respiratory tract neoplasm +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C3257"} ! pharynx neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001728 ! nasopharynx +property_value: exactMatch http://identifiers.org/mesh/D009303 +property_value: exactMatch http://identifiers.org/snomedct/126680004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027439 +property_value: exactMatch NCIT:C3257 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005381 +name: bone disorder +def: "Diseases of bones." [MESH:D001847] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:364803"} +synonym: "bone element disease" EXACT [MONDO:patterns/location] +synonym: "bone element disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of bone element" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of bone element" EXACT [] +synonym: "disorder of bone element" EXACT [MONDO:patterns/location_top] +synonym: "rare bone disease related to a common gene or pathway defect" RELATED [Orphanet:364803] +synonym: "skeletal disease" RELATED [DOID:0080001] +xref: DOID:0080001 {source="MONDO:equivalentTo", source="EFO:0004260"} +xref: EFO:0004260 {source="MONDO:equivalentTo"} +xref: ICD10CM:M80-M85 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:731.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:733.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001847 {source="DOID:0080001", source="MONDO:equivalentTo"} +xref: SCTID:76069003 {source="DOID:0080001", source="MONDO:equivalentTo"} +xref: UMLS:C0005940 {source="DOID:0080001", source="MONDO:equivalentTo"} +xref: UMLS:CN204768 {source="MONDO:equivalentObsolete"} +is_a: MONDO:0005172 {source="EFO:0004260", source="MONDO:Redundant"} ! skeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +relationship: disease_has_location UBERON:0002481 ! bone tissue +property_value: exactMatch DOID:0080001 +property_value: exactMatch http://identifiers.org/mesh/D001847 +property_value: exactMatch http://identifiers.org/snomedct/76069003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005940 +property_value: exactMatch https://icd.codes/icd10cm/M80-M85 +property_value: excluded_subClassOf MONDO:0003900 {source="DOID:0080001"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005384 +name: partial epilepsy +def: "A seizure caused by a localized disorder." [NCIT:P378] +synonym: "focal epilepsy" RELATED [DOID:2234] +synonym: "localisation-related epilepsy" EXACT [DOID:2234] +synonym: "partial epilepsy" EXACT [DOID:2234] +xref: DOID:2234 {source="MONDO:equivalentTo", source="EFO:0004263"} +xref: EFO:0004263 {source="MONDO:equivalentTo"} +xref: ICD9:345.50 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D004828 {source="DOID:2234", source="MONDO:equivalentTo", source="EFO:0004263"} +xref: NCIT:C122812 {source="DOID:2234", source="MONDO:equivalentTo"} +xref: SCTID:230381009 {source="DOID:2234", source="MONDO:equivalentTo"} +xref: UMLS:C0014547 {source="NCIT:C122812", source="DOID:2234", source="MONDO:equivalentTo"} +is_a: MONDO:0005027 {source="DOID:2234", source="EFO:0004263", source="MESH:D004828", source="NCIT:C122812"} ! epilepsy +property_value: exactMatch DOID:2234 +property_value: exactMatch http://identifiers.org/mesh/D004828 +property_value: exactMatch http://identifiers.org/snomedct/230381009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014547 +property_value: exactMatch NCIT:C122812 + +[Term] +id: MONDO:0005385 +name: vascular disorder +def: "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome." [https://doi.org/10.1007/978-3-540-78785-3_7] +comment: The etiology of vasculopathy is generally unknown and the condition is frequently not pathologically proven. Vasculitis, on the other hand, is a more specific term and is defined as inflammation of the wall of a blood vessel. However, the term vasculopathy is also used for “vasculitis” that has not been pathologically established. +synonym: "disease of vasculature" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vasculature" EXACT [] +synonym: "disorder of vasculature" EXACT [MONDO:patterns/location_top] +synonym: "vascular disorder" EXACT [NCIT:C35117] +synonym: "vascular tissue disease" EXACT [DOID:178] +synonym: "vasculature disease" EXACT [MONDO:patterns/location] +synonym: "vasculature disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vasculopathy" RELATED [https://doi.org/10.1007/978-3-540-78785-3_7, https://orcid.org/0000-0002-0736-9199] +xref: DOID:178 {source="MONDO:equivalentTo", source="EFO:0004264"} +xref: EFO:0004264 {source="MONDO:equivalentTo"} +xref: ICD10CM:I00-I99 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD10CM:I70-I79 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:442.9 {source="DOID:178"} +xref: MESH:D014652 {source="MONDO:equivalentTo", source="DOID:178", source="EFO:0004264"} +xref: NCIT:C26693 {source="MONDO:otherHierarchy", source="DOID:178"} +xref: NCIT:C35117 {source="MONDO:equivalentTo", source="DOID:178"} +xref: SCTID:27550009 {source="MONDO:equivalentTo", source="DOID:178"} +xref: UMLS:C0042373 {source="MONDO:equivalentTo", source="NCIT:C35117", source="DOID:178"} +is_a: MONDO:0004995 {source="DOID:178", source="EFO:0004264", source="MESH:D014652", source="MONDO:Redundant", source="NCIT:C35117"} ! cardiovascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002049 ! vasculature +relationship: disease_has_location UBERON:0002049 ! vasculature +relationship: disease_has_location UBERON:0007798 {source="NCIT:C35117"} ! vascular system +property_value: exactMatch DOID:178 +property_value: exactMatch http://identifiers.org/mesh/D014652 +property_value: exactMatch http://identifiers.org/snomedct/27550009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042373 +property_value: exactMatch https://icd.codes/icd10cm/I00-I99 +property_value: exactMatch https://icd.codes/icd10cm/I70-I79 +property_value: exactMatch NCIT:C35117 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: relatedMatch NCIT:C26693 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3602 xsd:string + +[Term] +id: MONDO:0005387 +name: primary ovarian failure +def: "Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries." [NCIT:C113352] +synonym: "female hypergonadotropic hypogonadism" RELATED [] +synonym: "hypergonadotrophic ovarian failure" RELATED [] +synonym: "hypergonadotropic hypogonadism" EXACT [DOID:5426] +synonym: "hypergonadotropic hypogonadism (female)" EXACT [NCIT:C113352] +synonym: "premature menopause" RELATED [DOID:5426] +synonym: "premature ovarian failure" RELATED [MESH:D016649, Orphanet:619] +synonym: "premature ovarian insufficiency" RELATED [DOID:5426] +synonym: "primary female hypogonadism" RELATED [] +synonym: "primary ovarian failure" EXACT [NCIT:C113352] +synonym: "primary ovarian insufficiency" EXACT [DOID:5426, NCIT:C113352] +xref: DOID:5426 {source="EFO:0004266", source="MONDO:equivalentTo"} +xref: EFO:0004266 {source="MONDO:equivalentTo"} +xref: ICD10CM:E28.3 {source="MONDO:equivalentTo", source="DOID:5426"} +xref: ICD9:253.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:256.39 +xref: MESH:D016649 {source="EFO:0004266", source="MONDO:equivalentTo", source="DOID:5426"} +xref: NCIT:C113352 {source="MONDO:equivalentTo", source="DOID:5426"} +xref: Orphanet:619 {source="MONDO:equivalentTo", source="DOID:5426"} +xref: SCTID:370999003 {source="MONDO:equivalentTo"} +xref: SCTID:65846009 {source="MONDO:equivalentTo", source="DOID:5426"} +xref: UMLS:C0085215 {source="MONDO:equivalentTo", source="DOID:5426"} +is_a: MONDO:0005558 {source="DOID:5426", source="EFO:0004266/inferred", source="MESH:D016649", source="NCIT:C113352/inferred"} ! ovarian disorder +property_value: exactMatch DOID:5426 +property_value: exactMatch http://identifiers.org/mesh/D016649 +property_value: exactMatch http://identifiers.org/snomedct/370999003 +property_value: exactMatch http://identifiers.org/snomedct/65846009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085215 +property_value: exactMatch https://icd.codes/icd10cm/E28.3 +property_value: exactMatch NCIT:C113352 +property_value: exactMatch Orphanet:619 + +[Term] +id: MONDO:0005395 +name: movement disorder +def: "Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement." [NCIT:C116757] +synonym: "movement disease" EXACT [MONDO:0003151] +synonym: "movement disorder" EXACT [] +synonym: "movement disorders" EXACT [NCIT:C116757] +xref: DOID:480 {source="MONDO:equivalentTo"} +xref: EFO:0004280 {source="MONDO:equivalentTo"} +xref: ICD9:333.90 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:333.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009069 {source="DOID:480", source="MONDO:equivalentTo", source="EFO:0004280"} +xref: NCIT:C116757 {source="DOID:480", source="MONDO:equivalentTo", source="EFO:0004280", source="MONDO:exact-label-match"} +xref: SCTID:60342002 {source="DOID:480", source="MONDO:equivalentTo", source="EFO:0004280"} +is_a: MONDO:0005071 {source="DOID:480/inferred", source="EFO:0004280", source="MESH:D009069/inferred", source="NCIT:C116757/inferred"} ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_major_feature HP:0100022 ! Abnormality of movement +relationship: disease_has_major_feature HP:0100022 ! Abnormality of movement +property_value: exactMatch DOID:480 +property_value: exactMatch http://identifiers.org/mesh/D009069 +property_value: exactMatch http://identifiers.org/snomedct/60342002 +property_value: exactMatch NCIT:C116757 + +[Term] +id: MONDO:0005401 +name: colonic neoplasm +def: "A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." [NCIT:C2953] +synonym: "colon neoplasm" EXACT [NCIT:C2953] +synonym: "colon neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "colon tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2953] +synonym: "colonic neoplasm" EXACT [NCIT:C2953] +synonym: "colonic tumor" EXACT [NCIT:C2953] +synonym: "neoplasm of colon" EXACT [MONDO:patterns/neoplasm, NCIT:C2953] +synonym: "neoplasm of the colon" EXACT [NCIT:C2953] +synonym: "tumor of colon" EXACT [MONDO:patterns/neoplasm, NCIT:C2953] +synonym: "tumor of the colon" EXACT [NCIT:C2953] +xref: EFO:0004288 {source="MONDO:equivalentTo"} +xref: MESH:D003110 {source="EFO:0004288", source="DOID:219", source="MONDO:equivalentTo"} +xref: NCIT:C2953 {source="EFO:0004288", source="MONDO:equivalentTo"} +xref: UMLS:C0009375 {source="MONDO:equivalentTo", source="NCIT:C2953"} +is_a: MONDO:0003409 {source="MESH:D003110/inferred", source="MONDO:Redundant"} ! colonic disorder +is_a: MONDO:0005335 {source="MESH:D003110", source="NCIT:C2953"} ! colorectal neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch http://identifiers.org/mesh/D003110 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009375 +property_value: exactMatch NCIT:C2953 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005405 +name: childhood onset asthma +def: "Asthma that starts in childhood." [EFO:0004591] +synonym: "asthma of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "childhood asthma" EXACT [MONDO:design_pattern] +synonym: "pediatric asthma" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: EFO:0004591 {source="MONDO:equivalentTo"} +xref: SCTID:233678006 {source="MONDO:equivalentTo"} +xref: UMLS:C0264408 {source="MONDO:equivalentTo"} +is_a: MONDO:0004979 {source="EFO:0004591", source="MONDO:Redundant"} ! asthma +intersection_of: MONDO:0004979 ! asthma +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://identifiers.org/snomedct/233678006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264408 + +[Term] +id: MONDO:0005406 +name: gestational diabetes +def: "Carbohydrate intolerance first diagnosed during pregnancy." [NCIT:P378] +synonym: "diabetes in pregnancy" EXACT [NCIT:C34942] +synonym: "GDM" EXACT ABBREVIATION [DOID:11714] +synonym: "gestational diabetes mellitus" EXACT [DOID:11714] +synonym: "maternal gestational diabetes mellitus" EXACT [DOID:11714] +xref: DOID:11714 {source="MONDO:equivalentTo", source="EFO:0004593"} +xref: EFO:0004593 {source="DOID:11714", source="MONDO:equivalentTo"} +xref: MESH:D016640 {source="DOID:11714", source="MONDO:equivalentTo"} +xref: NCIT:C34942 {source="DOID:11714", source="MONDO:equivalentTo", source="EFO:0004593"} +xref: SCTID:11687002 {source="DOID:11714", source="MONDO:equivalentTo", source="EFO:0004593"} +xref: UMLS:C0085207 {source="DOID:11714", source="MONDO:equivalentTo", source="NCIT:C34942"} +is_a: MONDO:0005015 {source="DOID:11714", source="EFO:0004593", source="MESH:D016640", source="MONDO:Redundant", source="NCIT:C34942"} ! diabetes mellitus +is_a: MONDO:0024575 {source="MESH:D016640", source="MONDO:Redundant", source="MONDO:cjm"} ! pregnancy disorder +intersection_of: MONDO:0005015 ! diabetes mellitus +intersection_of: MONDO:0024575 ! pregnancy disorder +property_value: exactMatch DOID:11714 +property_value: exactMatch http://identifiers.org/mesh/D016640 +property_value: exactMatch http://identifiers.org/snomedct/11687002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085207 +property_value: exactMatch NCIT:C34942 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/pregnancy_form_of_disorder.yaml + +[Term] +id: MONDO:0005408 +name: diabetes mellitus type 2 associated cataract +def: "Diabetic cataracts are thought to be caused by hyperglycemia associated with disturbed glucose metabolism" [EFO:0004596] +xref: EFO:0004596 {source="MONDO:equivalentTo"} +is_a: MONDO:0005129 {source="EFO:0004596", source="MONDO:Redundant"} ! cataract +intersection_of: MONDO:0005129 ! cataract +intersection_of: disease_arises_from_feature MONDO:0005148 ! type 2 diabetes mellitus +relationship: disease_arises_from_feature MONDO:0005148 ! type 2 diabetes mellitus + +[Term] +id: MONDO:0005411 +name: gallbladder cancer +def: "A malignant neoplasm involving the gall bladder" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of gall bladder" EXACT [MONDO:patterns/cancer] +synonym: "gall bladder cancer" EXACT [MONDO:patterns/location] +synonym: "gallbladder Ca" EXACT [DOID:3121] +synonym: "gallbladder neoplasm" BROAD [DOID:3121, MTH:NOCODE] +synonym: "localized malignant gallbladder neoplasm" EXACT [DOID:3121, NCIT:C35676] +synonym: "malignant gall bladder neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant gallbladder neoplasm" EXACT [NCIT:C7481] +synonym: "malignant gallbladder tumor" EXACT [NCIT:C7481] +synonym: "malignant neoplasm of gall bladder" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of gallbladder" EXACT [DOID:3121, NCIT:C7481] +synonym: "malignant neoplasm of the gallbladder" EXACT [NCIT:C7481] +synonym: "malignant tumor of gallbladder" EXACT [NCIT:C7481] +synonym: "malignant tumor of the gallbladder" EXACT [DOID:3121, NCIT:C7481] +synonym: "malignant tumour of gallbladder" EXACT [DOID:3121] +synonym: "tumor of the gallbladder" BROAD [DOID:3121, NCIT:C3048] +xref: DOID:3121 {source="MONDO:equivalentTo", source="EFO:0004606"} +xref: EFO:0004606 {source="MONDO:equivalentTo"} +xref: GARD:0009328 {source="MONDO:equivalentTo"} +xref: ICD9:156.0 {source="DOID:3121", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:156.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C7481 {source="DOID:3121", source="MONDO:equivalentTo"} +xref: ONCOTREE:GBC {source="MONDO:equivalentTo"} +xref: SCTID:363353009 {source="DOID:3121", source="MONDO:equivalentTo"} +xref: UMLS:C0153452 {source="DOID:3121", source="MONDO:equivalentTo", source="NCIT:C7481"} +is_a: MONDO:0002516 ! digestive system cancer +is_a: MONDO:0021253 {source="MONDO:Redundant", source="NCIT:C7481"} ! gallbladder neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:3121 +property_value: exactMatch http://identifiers.org/snomedct/363353009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153452 +property_value: exactMatch NCIT:C7481 +property_value: excluded_subClassOf MONDO:0003060 {source="DOID:3121"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005441 +name: otitis media +def: "Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever." [NCIT:C34885] +synonym: "inflammation of middle ear" EXACT [] +synonym: "medial otitis" EXACT [NCIT:C34885] +synonym: "middle Ear Inflammation" EXACT [NCIT:C34885] +synonym: "middle ear inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site, NCIT:C34885] +synonym: "otitis Media" EXACT [NCIT:C34885] +synonym: "otitis media (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:10754 {source="EFO:0004992", source="MONDO:equivalentTo"} +xref: EFO:0004992 {source="MONDO:equivalentTo"} +xref: HP:0000388 {source="MONDO:otherHierarchy"} +xref: ICD9:382.9 {source="DOID:10754", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D010033 {source="EFO:0004992", source="DOID:10754", source="MONDO:equivalentTo"} +xref: NCIT:C34885 {source="EFO:0004992", source="DOID:10754", source="MONDO:equivalentTo"} +xref: SCTID:65363002 {source="EFO:0004992", source="DOID:10754", source="MONDO:equivalentTo"} +xref: UMLS:C0029882 {source="DOID:10754", source="MONDO:equivalentTo", source="NCIT:C34885"} +is_a: MONDO:0003276 {source="DOID:10754", source="MONDO:Redundant", source="NCIT:C34885"} ! middle ear disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001756 ! middle ear +relationship: disease_has_inflammation_site UBERON:0001756 ! middle ear +property_value: exactMatch DOID:10754 +property_value: exactMatch http://identifiers.org/mesh/D010033 +property_value: exactMatch http://identifiers.org/snomedct/65363002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029882 +property_value: exactMatch NCIT:C34885 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "otitis media (disease)" xsd:string + +[Term] +id: MONDO:0005447 +name: testicular cancer +def: "A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma." [NCIT:C7251] +synonym: "cancer of testis" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of testis" EXACT [MONDO:patterns/cancer, NCIT:C7251] +synonym: "malignant neoplasm of the testis" EXACT [NCIT:C7251] +synonym: "malignant testicular neoplasm" EXACT [NCIT:C7251] +synonym: "malignant testicular tumor" EXACT [NCIT:C7251] +synonym: "malignant testis neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of testis" EXACT [NCIT:C7251] +synonym: "malignant tumor of the testis" EXACT [NCIT:C7251] +synonym: "testicular tumor" BROAD [DOID:2998, NCIT:C3404] +synonym: "testis cancer" EXACT [DOID:2998, MONDO:patterns/location] +synonym: "testis neoplasm" BROAD [DOID:2998] +xref: DOID:2998 {source="MONDO:equivalentTo", source="EFO:0005088"} +xref: EFO:0005088 {source="MONDO:equivalentTo"} +xref: GARD:0007746 {source="MONDO:equivalentTo"} +xref: ICD9:186 {source="DOID:2998"} +xref: ICD9:186.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D013736 {source="MONDO:equivalentTo", source="DOID:2998"} +xref: NCIT:C5053 {source="DOID:2998", source="MONDO:directSiblingOf"} +xref: NCIT:C7251 {source="MONDO:equivalentTo", source="DOID:2998"} +xref: OMIM:273300 {source="DOID:2998", source="MONDO:directSiblingOf"} +xref: SCTID:363449006 {source="MONDO:equivalentTo", source="DOID:2998"} +is_a: MONDO:0005836 {source="DOID:2998", source="MESH:D013736", source="MONDO:Redundant", source="NCIT:C7251"} ! male reproductive organ cancer +is_a: MONDO:0021348 {source="MONDO:Redundant", source="NCIT:C7251"} ! neoplasm of testis +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:2998 +property_value: exactMatch http://identifiers.org/mesh/D013736 +property_value: exactMatch http://identifiers.org/snomedct/363449006 +property_value: exactMatch NCIT:C7251 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005449 +name: conduction system disorder +def: "A disease involving the conducting system of heart." [MONDO:patterns/location_top] +synonym: "conducting system of heart disease" EXACT [MONDO:patterns/location] +synonym: "conducting system of heart disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of conducting system of heart" EXACT [MONDO:cjm, MONDO:patterns/location_top] +synonym: "disease or disorder of conducting system of heart" EXACT [] +synonym: "disorder of conducting system of heart" EXACT [MONDO:patterns/location_top] +xref: EFO:0005137 {source="MONDO:equivalentTo"} +is_a: MONDO:0003939 ! muscle tissue disorder +is_a: MONDO:0024643 ! myocardial disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002350 ! conducting system of heart +relationship: disease_has_location UBERON:0002350 ! conducting system of heart +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005454 +name: lung neuroendocrine neoplasm +def: "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma." [NCIT:C5670] +synonym: "lung NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "lung neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5670] +synonym: "lung neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "lung neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of lung" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C5670] +synonym: "neuroendocrine neoplasm of the lung" EXACT [NCIT:C5670] +synonym: "pulmonary neuroendocrine neoplasm" EXACT [NCIT:C5670] +synonym: "pulmonary neuroendocrine tumor" RELATED [DOID:5410] +xref: DOID:5410 {source="MONDO:equivalentTo", source="EFO:0005220"} +xref: EFO:0005220 {source="MONDO:equivalentTo"} +xref: ICD9:209.61 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5670 {source="DOID:5410", source="MONDO:equivalentTo", source="EFO:0005220"} +xref: ONCOTREE:LNET {source="MONDO:equivalentTo"} +xref: SCTID:707594002 {source="DOID:5410", source="MONDO:equivalentTo", source="EFO:0005220"} +xref: UMLS:C1334452 {source="DOID:5410", source="NCIT:C5670", source="MONDO:equivalentTo"} +is_a: MONDO:0019496 {source="EFO:0005220", source="MONDO:Redundant", source="NCIT:C5670"} ! neuroendocrine neoplasm +is_a: MONDO:0021117 {source="MONDO:Redundant", source="NCIT:C5670", source="ONCOTREE:LNET"} ! lung neoplasm +intersection_of: MONDO:0019496 {source="NCIT:C5670"} ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002048 {source="NCIT:C5670"} ! lung +property_value: exactMatch DOID:5410 +property_value: exactMatch http://identifiers.org/snomedct/707594002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334452 +property_value: exactMatch NCIT:C5670 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0005461 +name: endometrium adenocarcinoma +def: "An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma." [NCIT:C7359] +synonym: "adenocarcinoma of endometrium" EXACT [NCIT:C7359] +synonym: "adenocarcinoma of the endometrium" EXACT [DOID:2870, NCIT:C7359] +synonym: "adenocarcinoma of uterus" EXACT [DOID:2870] +synonym: "adenocarcinoma, endometrial, malignant" EXACT [NCIT:C7359] +synonym: "endometrial adenoacanthoma" EXACT [DOID:2870] +synonym: "endometrial adenocarcinoma" EXACT [NCIT:C7359] +synonym: "endometrial endometrioid adenocarcinoma" RELATED [DOID:2870] +synonym: "endometrial endometrioid adenocarcinoma with squamous differentiation" EXACT [DOID:2870, NCIT:C8027] +synonym: "endometrioid adenoma or carcinoma" EXACT [DOID:2870] +synonym: "endometrioid adenoma or carcinoma NOS (morphologic abnormality)" EXACT [DOID:2870] +synonym: "endometrioid adenomas and carcinomas" EXACT [DOID:2870] +synonym: "endometrioid adenomas and carcinomas (morphologic abnormality)" EXACT [DOID:2870] +synonym: "endometrioid carcinoma of endometrium" BROAD [DOID:2870, NCIT:C6287] +synonym: "endometrium adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:2870 {source="MONDO:equivalentTo", source="EFO:0005232"} +xref: EFO:0005232 {source="MONDO:equivalentTo"} +xref: NCIT:C6287 {source="DOID:2870", source="MONDO:directSiblingOf"} +xref: NCIT:C7359 {source="DOID:2870", source="MONDO:equivalentTo", source="EFO:0005232"} +xref: UMLS:C0279763 {source="DOID:2870", source="MONDO:equivalentTo"} +xref: UMLS:C1153706 {source="DOID:2870", source="MONDO:equivalentTo", source="NCIT:C7359"} +xref: UMLS:C1336905 {source="DOID:2870", source="MONDO:directSiblingOf"} +is_a: MONDO:0002447 {source="DOID:2870", source="MONDO:Redundant", source="NCIT:C7359"} ! endometrial carcinoma +is_a: MONDO:0004970 {source="DOID:2870", source="EFO:0005232", source="MONDO:Redundant", source="NCIT:C7359"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch DOID:2870 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279763 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1153706 +property_value: exactMatch NCIT:C7359 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005475 +name: migraine with aura +def: "A migraine disorder characterized by episodes that are preceded by focal neurological symptoms." [NCIT:P378] +synonym: "classic migraine" EXACT [DOID:10024] +xref: DOID:10024 {source="MONDO:equivalentTo", source="EFO:0005295"} +xref: EFO:0005295 {source="MONDO:equivalentTo"} +xref: HP:0002077 {source="MONDO:otherHierarchy", source="EFO:0005295"} +xref: ICD9:346.0 {source="EFO:0005295", source="DOID:10024"} +xref: ICD9:346.00 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D020325 {source="MONDO:equivalentTo", source="EFO:0005295", source="DOID:10024"} +xref: NCIT:C117005 {source="MONDO:equivalentTo", source="EFO:0005295", source="DOID:10024"} +xref: SCTID:4473006 {source="MONDO:equivalentTo", source="EFO:0005295", source="DOID:10024"} +xref: UMLS:C0154723 {source="MONDO:equivalentTo", source="NCIT:C117005", source="DOID:10024"} +is_a: MONDO:0005277 {source="DOID:10024", source="EFO:0005295", source="MESH:D020325", source="NCIT:C117005"} ! migraine disorder +property_value: exactMatch DOID:10024 +property_value: exactMatch http://identifiers.org/mesh/D020325 +property_value: exactMatch http://identifiers.org/snomedct/4473006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154723 +property_value: exactMatch NCIT:C117005 + +[Term] +id: MONDO:0005476 +name: atrioventricular node disorder +def: "A disease involving the atrioventricular node." [MONDO:patterns/location_top] +synonym: "atrioventricular node disease" EXACT [MONDO:patterns/location] +synonym: "atrioventricular node disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of atrioventricular node" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of atrioventricular node" EXACT [] +synonym: "disorder of atrioventricular node" EXACT [MONDO:patterns/location_top] +xref: EFO:0005305 {source="MONDO:equivalentTo"} +is_a: MONDO:0005449 {source="EFO:0005305", source="MONDO:Entailed", source="MONDO:Redundant"} ! conduction system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002352 ! atrioventricular node +relationship: disease_has_location UBERON:0002352 ! atrioventricular node +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005485 +name: psychotic disorder +def: "An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities." [Wikipedia:Psychosis] +synonym: "mental or behavioural disorder" BROAD [DOID:2468] +synonym: "psychosis" EXACT [MONDO:ambiguous] +xref: DOID:2468 {source="MONDO:equivalentTo"} +xref: EFO:0005407 {source="MONDO:equivalentTo"} +xref: HP:0000709 {source="MONDO:otherHierarchy"} +xref: ICD9:298.8 {source="DOID:2468"} +xref: ICD9:298.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C78576 {source="MONDO:equivalentTo", source="EFO:0005407"} +xref: SCTID:69322001 {source="MONDO:equivalentTo"} +is_a: MONDO:0002039 {source="DOID:2468"} ! cognitive disorder +is_a: MONDO:0005084 {source="EFO:0005407"} ! mental disorder +property_value: exactMatch DOID:2468 +property_value: exactMatch http://identifiers.org/snomedct/69322001 +property_value: exactMatch NCIT:C78576 + +[Term] +id: MONDO:0005495 +name: adrenal gland disorder +def: "A disease involving the adrenal gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "adrenal gland disease" EXACT [MONDO:patterns/location, NCIT:C26690] +synonym: "adrenal gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "adrenal gland diseases" EXACT [NCIT:C26690] +synonym: "adrenal gland disorder" EXACT [NCIT:C26690] +synonym: "adrenal gland disorders" EXACT [NCIT:C26690] +synonym: "disease of adrenal gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of adrenal gland" EXACT [] +synonym: "disorder of adrenal gland" EXACT [MONDO:patterns/location_top] +xref: DOID:9553 {source="MONDO:equivalentTo", source="EFO:0005539"} +xref: EFO:0005539 {source="MONDO:equivalentTo"} +xref: ICD9:255 {source="DOID:9553"} +xref: ICD9:255.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:255.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9553"} +xref: MESH:D000307 {source="MONDO:equivalentTo", source="DOID:9553"} +xref: NCIT:C26690 {source="MONDO:equivalentTo", source="DOID:9553"} +xref: SCTID:30171000 {source="MONDO:equivalentTo", source="DOID:9553"} +is_a: MONDO:0005151 {source="DOID:9553", source="EFO:0005539", source="MESH:D000307", source="MONDO:Redundant"} ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +relationship: disease_has_location UBERON:0002369 ! adrenal gland +property_value: exactMatch DOID:9553 +property_value: exactMatch http://identifiers.org/mesh/D000307 +property_value: exactMatch http://identifiers.org/snomedct/30171000 +property_value: exactMatch NCIT:C26690 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005496 +name: bile duct carcinoma +def: "A carcinoma that arises from epithelial cells of the bile duct" [https://orcid.org/0000-0002-6601-2165] +synonym: "bile duct cancer" BROAD [NCIT:C27814] +synonym: "bile duct cancer (including cholangiocarcinoma)" EXACT [NCIT:C27814] +synonym: "bile duct carcinoma" EXACT [MONDO:patterns/location, NCIT:C27814] +synonym: "carcinoma of bile duct" EXACT [MONDO:patterns/carcinoma] +xref: DOID:4897 {source="MONDO:equivalentTo", source="EFO:0005540"} +xref: EFO:0005540 {source="MONDO:equivalentTo"} +xref: NCIT:C27814 {source="DOID:4897", source="MONDO:equivalentTo", source="EFO:0005540"} +xref: UMLS:C0740277 {source="DOID:4897", source="MONDO:equivalentTo", source="NCIT:C27814"} +is_a: MONDO:0003059 {source="DOID:4897", source="MONDO:Redundant"} ! bile duct cancer +is_a: MONDO:0018531 ! carcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch DOID:4897 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0740277 +property_value: exactMatch NCIT:C27814 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005497 +name: bone development disease +def: "A disease involving the bone development." [MONDO:patterns/location_top] +synonym: "bone development disease" EXACT [MONDO:patterns/location] +synonym: "bone development disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of bone development" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of bone development" EXACT [] +synonym: "disorder of bone development" EXACT [MONDO:patterns/location_top] +xref: DOID:0080006 {source="EFO:0005541", source="MONDO:equivalentTo"} +xref: EFO:0005541 {source="MONDO:equivalentTo"} +xref: SCTID:371521007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005381 {source="DOID:0080006", source="EFO:0005541"} ! bone disorder +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0060348 ! bone development +relationship: disease_has_basis_in_disruption_of GO:0060348 ! bone development +property_value: exactMatch DOID:0080006 +property_value: exactMatch http://identifiers.org/snomedct/371521007 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0005499 +name: brain glioma +def: "A malignant glioma that involves the brain." [MONDO:patterns/location] +synonym: "brain malignant glioma" EXACT [MONDO:patterns/location] +synonym: "malignant glioma of brain" EXACT [MONDO:design_pattern] +xref: DOID:0060108 {source="EFO:0005543", source="MONDO:equivalentTo"} +xref: EFO:0005543 {source="MONDO:equivalentTo"} +xref: OMIM:613028 {source="EFO:0005543", source="MONDO:directSiblingOf"} +xref: OMIM:613029 {source="EFO:0005543", source="MONDO:directSiblingOf"} +xref: SCTID:254937005 {source="MONDO:equivalentTo"} +xref: UMLS:C0349661 {source="MONDO:equivalentTo"} +is_a: MONDO:0001657 {source="DOID:0060108", source="MONDO:Entailed", source="MONDO:Redundant"} ! brain cancer +is_a: MONDO:0100342 {source="DOID:0060108", source="MONDO:Redundant"} ! malignant glioma +intersection_of: MONDO:0100342 ! malignant glioma +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:0060108 +property_value: exactMatch http://identifiers.org/snomedct/254937005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349661 + +[Term] +id: MONDO:0005506 +name: eccrine sweat gland cancer +def: "An cancer with eccrine differentiation arising from the sweat glands.B" [EFO:0005553] +synonym: "cancer of eccrine sweat gland" EXACT [MONDO:patterns/cancer] +synonym: "eccrine sweat gland cancer" EXACT [MONDO:patterns/location] +synonym: "malignant eccrine neoplasm" EXACT [NCIT:C5559] +synonym: "malignant eccrine neoplasm of skin" EXACT [NCIT:C5559] +synonym: "malignant eccrine neoplasm of the skin" EXACT [NCIT:C5559] +synonym: "malignant eccrine skin neoplasm" EXACT [DOID:4921, NCIT:C5559] +synonym: "malignant eccrine skin tumor" EXACT [NCIT:C5559] +synonym: "malignant eccrine sweat gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant eccrine tumor" EXACT [DOID:4921, NCIT:C5559] +synonym: "malignant eccrine tumor of skin" EXACT [NCIT:C5559] +synonym: "malignant eccrine tumor of the skin" EXACT [NCIT:C5559] +synonym: "malignant neoplasm of eccrine sweat gland" EXACT [MONDO:patterns/cancer] +xref: DOID:4921 {source="EFO:0005553", source="MONDO:equivalentTo"} +xref: EFO:0005553 {source="MONDO:equivalentTo"} +xref: NCIT:C5559 {source="DOID:4921", source="MONDO:equivalentTo"} +xref: UMLS:C1334577 {source="DOID:4921", source="MONDO:equivalentTo", source="NCIT:C5559"} +is_a: MONDO:0002090 {source="MONDO:Redundant", source="NCIT:C5559"} ! eccrine sweat gland neoplasm +is_a: MONDO:0002206 {source="DOID:4921", source="MONDO:Redundant", source="NCIT:C5559"} ! sweat gland cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000423 ! eccrine sweat gland +property_value: exactMatch DOID:4921 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334577 +property_value: exactMatch NCIT:C5559 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005507 +name: gingival cancer +def: "A primary or metastatic malignant neoplasm that affects the gums." [NCIT:C9317] +synonym: "cancer of gingiva" EXACT [MONDO:patterns/cancer] +synonym: "gingiva cancer" EXACT [MONDO:patterns/location] +synonym: "gum cancer" RELATED [DOID:8602] +synonym: "malignant gingiva neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant gingival neoplasm" EXACT [NCIT:C9317] +synonym: "malignant gingival tumor" EXACT [DOID:8602, NCIT:C9317] +synonym: "malignant gum neoplasm" EXACT [NCIT:C9317] +synonym: "malignant gum tumor" EXACT [NCIT:C9317] +synonym: "malignant neoplasm of gingiva" EXACT [MONDO:patterns/cancer, NCIT:C9317] +synonym: "malignant neoplasm of gum" EXACT [DOID:8602, ICD9CM:143, NCIT:C9317] +synonym: "malignant neoplasm of other sites of gum" EXACT [DOID:8602] +synonym: "malignant neoplasm of the gingiva" EXACT [NCIT:C9317] +synonym: "malignant neoplasm of the gum" EXACT [NCIT:C9317] +synonym: "malignant tumor of gingiva" EXACT [NCIT:C9317] +synonym: "malignant tumor of gum" EXACT [NCIT:C9317] +synonym: "malignant tumor of the gingiva" EXACT [NCIT:C9317] +synonym: "malignant tumor of the gum" EXACT [NCIT:C9317] +synonym: "malignant tumour of gingiva" EXACT [DOID:8602] +xref: DOID:8602 {source="EFO:0005557", source="MONDO:equivalentTo"} +xref: EFO:0005557 {source="MONDO:equivalentTo"} +xref: ICD9:143 {source="DOID:8602", source="EFO:0005557"} +xref: ICD9:143.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:143.9 {source="DOID:8602", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10067807 {source="EFO:0005557"} +xref: NCIT:C9317 {source="DOID:8602", source="EFO:0005557", source="MONDO:equivalentTo"} +xref: SCTID:363382005 {source="DOID:8602", source="MONDO:equivalentTo"} +xref: UMLS:C0153364 {source="DOID:8602", source="MONDO:equivalentTo", source="NCIT:C9317"} +is_a: MONDO:0002129 ! bone cancer +is_a: MONDO:0005515 {source="DOID:8602", source="NCIT:C9317"} ! oral cavity cancer +is_a: MONDO:0021086 {source="MONDO:Redundant", source="NCIT:C9317"} ! gingival neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001828 ! gingiva +property_value: closeMatch http://identifiers.org/meddra/10067807 +property_value: exactMatch DOID:8602 +property_value: exactMatch http://identifiers.org/snomedct/363382005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153364 +property_value: exactMatch NCIT:C9317 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005515 +name: oral cavity cancer +def: "A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas." [NCIT:C9314] +synonym: "cancer of oral cavity" EXACT [MONDO:patterns/cancer] +synonym: "malignant mouth neoplasm" EXACT [NCIT:C9314] +synonym: "malignant mouth tumor" EXACT [NCIT:C9314] +synonym: "malignant neoplasm of anterior portion of floor of mouth" NARROW [DOID:8618] +synonym: "malignant neoplasm of floor of mouth" NARROW [DOID:8618, MTH:NOCODE] +synonym: "malignant neoplasm of lateral floor of mouth" NARROW [DOID:8618, MTH:U001372] +synonym: "malignant neoplasm of lateral portion of floor of mouth" NARROW [DOID:8618] +synonym: "malignant neoplasm of mouth" EXACT [NCIT:C9314] +synonym: "malignant neoplasm of oral cavity" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the mouth" EXACT [NCIT:C9314] +synonym: "malignant oral cavity neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9314] +synonym: "malignant oral cavity tumor" EXACT [NCIT:C9314] +synonym: "malignant tumor of anterior floor of mouth" EXACT [DOID:8618] +synonym: "malignant tumor of lateral floor of mouth" EXACT [DOID:8618] +synonym: "malignant tumor of mouth" EXACT [NCIT:C9314] +synonym: "malignant tumor of oral cavity" EXACT [] +synonym: "malignant tumor of the floor of the mouth" NARROW [DOID:8618, NCIT:C9318] +synonym: "malignant tumor of the mouth" EXACT [NCIT:C9314] +synonym: "mouth cancer" RELATED [] +synonym: "oral cavity cancer" EXACT [MONDO:patterns/location] +xref: DOID:8618 {source="MONDO:equivalentTo", source="EFO:0005570"} +xref: EFO:0005570 {source="MONDO:equivalentTo"} +xref: ICD9:144 {source="DOID:8618", source="EFO:0005570"} +xref: ICD9:144.0 {source="DOID:8618"} +xref: ICD9:144.1 {source="DOID:8618"} +xref: ICD9:144.9 {source="MONDO:relatedTo", source="DOID:8618"} +xref: ICD9:145.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:145.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:149.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C9314 {source="MONDO:equivalentTo", source="EFO:0005570"} +xref: SCTID:363505006 {source="MONDO:equivalentTo"} +is_a: MONDO:0002516 {source="DOID:8618", source="MONDO:Entailed", source="MONDO:Redundant"} ! digestive system cancer +is_a: MONDO:0005627 ! head and neck cancer +is_a: MONDO:0021245 {source="MONDO:Redundant", source="NCIT:C9314"} ! oral cavity neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000167 ! oral cavity +property_value: exactMatch DOID:8618 +property_value: exactMatch http://identifiers.org/snomedct/363505006 +property_value: exactMatch NCIT:C9314 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005517 +name: pharynx cancer +def: "A primary or metastatic malignant neoplasm that affects the pharynx." [NCIT:C7545] +synonym: "cancer of chordate pharynx" EXACT [MONDO:patterns/cancer] +synonym: "cancer of pharynx" EXACT [MONDO:patterns/cancer] +synonym: "chordate pharynx cancer" EXACT [] +synonym: "malignant chordate pharynx neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of chordate pharynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of pharynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant pharyngeal neoplasm" EXACT [NCIT:C7545] +synonym: "malignant pharyngeal tumor" EXACT [NCIT:C7545] +synonym: "malignant pharynx neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7545] +synonym: "malignant pharynx tumor" EXACT [NCIT:C7545] +synonym: "malignant tumor of pharynx" EXACT [NCIT:C7545] +synonym: "malignant tumor of the pharynx" EXACT [NCIT:C7545] +synonym: "pharyngeal cancer" RELATED [DOID:0060119] +synonym: "pharyngeal neoplasm" EXACT [DOID:0060119] +synonym: "pharynx cancer" EXACT [MONDO:patterns/location] +synonym: "pharynx neoplasm" BROAD [DOID:0060119] +xref: DOID:0060119 {source="EFO:0005577", source="MONDO:equivalentTo"} +xref: EFO:0005577 {source="MONDO:equivalentTo"} +xref: MESH:D010610 {source="MONDO:equivalentTo", source="DOID:0060119"} +xref: NCIT:C7545 {source="EFO:0005577", source="MONDO:equivalentTo"} +is_a: MONDO:0000376 ! respiratory system cancer +is_a: MONDO:0002516 {source="DOID:0060119", source="MONDO:Entailed", source="MONDO:Redundant"} ! digestive system cancer +is_a: MONDO:0020592 ! disorder of pharynx +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C7545"} ! pharynx neoplasm +is_a: MONDO:0021310 {source="NCIT:C7545"} ! malignant tumor of neck +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001042 ! chordate pharynx +property_value: exactMatch DOID:0060119 +property_value: exactMatch http://identifiers.org/mesh/D010610 +property_value: exactMatch NCIT:C7545 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005519 +name: renal pelvis carcinoma +def: "A carcinoma arising in the renal pelvis. The majority of renal pelvis carcinomas are transitional cell and less frequently squamous cell carcinomas." [EFO:0005582] +synonym: "cancer of renal pelvis" BROAD [MONDO:patterns/cancer] +synonym: "carcinoma of kidney pelvis" EXACT [DOID:4919, NCIT:C6142] +synonym: "carcinoma of renal pelvis" EXACT [MONDO:patterns/carcinoma, NCIT:C6142] +synonym: "carcinoma of the kidney pelvis" EXACT [NCIT:C6142] +synonym: "carcinoma of the renal pelvis" EXACT [NCIT:C6142] +synonym: "kidney pelvis carcinoma" EXACT [NCIT:C6142] +synonym: "kidney renal pelvis cancer" EXACT [NCIT:C6142] +synonym: "malignant neoplasm of renal pelvis" BROAD [DOID:4919, ICD9CM:189.1, MONDO:patterns/cancer] +synonym: "malignant renal pelvis neoplasm" BROAD [DOID:4919, MONDO:patterns/cancer, NCIT:C7525] +synonym: "renal pelvis cancer" BROAD [DOID:4919, MONDO:patterns/location] +synonym: "renal pelvis carcinoma" EXACT [NCIT:C6142] +xref: DOID:4919 {source="MONDO:equivalentTo", source="EFO:0005582"} +xref: EFO:0005582 {source="MONDO:equivalentTo"} +xref: ICD10CM:C65 {source="DOID:4919", source="MONDO:equivalentTo"} +xref: ICD9:189.1 {source="DOID:4919", source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0005582"} +xref: NCIT:C6142 {source="DOID:4919", source="MONDO:equivalentTo", source="EFO:0005582"} +xref: SCTID:363457009 {source="DOID:4919", source="MONDO:equivalentTo"} +xref: UMLS:C0153618 {source="DOID:4919", source="MONDO:equivalentTo"} +xref: UMLS:C1335749 {source="DOID:4919", source="MONDO:equivalentTo"} +is_a: MONDO:0005206 {source="MONDO:Redundant", source="NCIT:C6142"} ! renal carcinoma +is_a: MONDO:0044919 ! malignant renal pelvis neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch DOID:4919 +property_value: exactMatch http://identifiers.org/snomedct/363457009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153618 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335749 +property_value: exactMatch https://icd.codes/icd10cm/C65 +property_value: exactMatch NCIT:C6142 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005522 +name: small intestine carcinoma +def: "A carcinoma that arises from epithelial cells of the small intestine" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of small bowel" BROAD [NCIT:C7724] +synonym: "cancer of the small bowel" BROAD [DOID:4907, NCIT:C7724] +synonym: "carcinoma of small bowel" EXACT [NCIT:C7724] +synonym: "carcinoma of small intestine" EXACT [MONDO:patterns/carcinoma, NCIT:C7724] +synonym: "carcinoma of the small bowel" EXACT [NCIT:C7724] +synonym: "carcinoma of the small intestine" EXACT [NCIT:C7724] +synonym: "small bowel cancer" BROAD [DOID:4907, NCIT:C7724] +synonym: "small bowel carcinoma" EXACT [NCIT:C7724] +synonym: "small intestinal cancer" BROAD [NCIT:C7724] +synonym: "small intestinal carcinoma" EXACT [DOID:4907, NCIT:C7724] +synonym: "small intestine cancer" BROAD [NCIT:C7724] +synonym: "small intestine cancer, NOS" EXACT [NCIT:C7724] +synonym: "small intestine carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4907 {source="EFO:0005588", source="MONDO:equivalentTo"} +xref: EFO:0005588 {source="MONDO:equivalentTo"} +xref: NCIT:C7724 {source="EFO:0005588", source="MONDO:equivalentTo", source="ONCOTREE:SIC", source="DOID:4907"} +xref: ONCOTREE:SIC {source="MONDO:equivalentTo"} +xref: SCTID:448664009 {source="MONDO:equivalentTo"} +is_a: MONDO:0000956 {source="DOID:4907", source="MONDO:Redundant", source="NCIT:C7724"} ! small intestine cancer +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C7724"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:4907 +property_value: exactMatch http://identifiers.org/snomedct/448664009 +property_value: exactMatch NCIT:C7724 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005524 +name: sweat gland carcinoma +def: "A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma." [EFO:0005591] +synonym: "carcinoma of sweat gland" EXACT [MONDO:patterns/carcinoma, NCIT:C6938] +synonym: "carcinoma of the sweat gland" EXACT [DOID:5667, NCIT:C6938] +synonym: "carcinoma, sweat gland, malignant" EXACT [NCIT:C6938] +synonym: "sweat gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C6938] +synonym: "sweat gland carcinoma/apocrine eccrine carcinoma" RELATED [ONCOTREE:AECA] +xref: DOID:5667 {source="MONDO:equivalentTo", source="EFO:0005591"} +xref: EFO:0005591 {source="MONDO:equivalentTo"} +xref: ICDO:8400/3 {source="NCIT:C6938"} +xref: NCIT:C6938 {source="DOID:5667", source="MONDO:equivalentTo", source="EFO:0005591", source="MONDO:exact-label-match"} +xref: ONCOTREE:AECA {source="MONDO:equivalentTo"} +xref: UMLS:C1412016 {source="NCIT:C6938", source="DOID:5667", source="MONDO:equivalentTo"} +is_a: MONDO:0002206 {source="DOID:5667", source="MONDO:Redundant", source="NCIT:C6938"} ! sweat gland cancer +is_a: MONDO:0004970 {source="NCIT:C6938"} ! adenocarcinoma +is_a: MONDO:0006973 {source="MONDO:Redundant", source="NCIT:C6938"} ! skin appendage carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001820 ! sweat gland +property_value: exactMatch DOID:5667 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1412016 +property_value: exactMatch NCIT:C6938 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005528 +name: inborn vitamin metabolic disorder +def: "An acquired metabolic disease that is has its basis in the disruption of vitamin metabolic process." [MONDO:patterns/inborn_metabolic] +synonym: "inborn error of vitamin metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn vitamin metabolic process disorder" EXACT [] +synonym: "rare inborn error of vitamin metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "vitamin metabolic disorder" RELATED [DOID:0050718] +xref: DOID:0050718 {source="EFO:0005596", source="MONDO:equivalentTo"} +xref: EFO:0005596 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 {source="DOID:0050718", source="MONDO:Redundant"} ! inborn errors of metabolism +is_a: MONDO:0024298 {source="MONDO:cjm"} ! vitamin deficiency disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006766 ! vitamin metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006766 ! vitamin metabolic process +property_value: exactMatch DOID:0050718 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0005538 +name: proctitis +def: "An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease." [NCIT:P378] +synonym: "anus inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of anus" EXACT [] +synonym: "rectitis" EXACT [NCIT:C38011] +xref: DOID:3127 {source="MONDO:equivalentTo", source="EFO:0005628"} +xref: EFO:0005628 {source="MONDO:equivalentTo"} +xref: ICD9:569.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D011349 {source="MONDO:equivalentTo", source="DOID:3127", source="EFO:0005628"} +xref: NCIT:C38011 {source="MONDO:equivalentTo", source="DOID:3127", source="EFO:0005628"} +xref: SCTID:3951002 {source="MONDO:equivalentTo", source="DOID:3127", source="EFO:0005628"} +xref: UMLS:C0033246 {source="NCIT:C38011", source="MONDO:equivalentTo", source="DOID:3127"} +is_a: MONDO:0002519 {source="MONDO:Redundant", source="NCIT:C38011/inferred"} ! anus disorder +is_a: MONDO:0005265 {source="EFO:0005628"} ! inflammatory bowel disease +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001245 ! anus +relationship: disease_has_inflammation_site UBERON:0001245 ! anus +property_value: exactMatch DOID:3127 +property_value: exactMatch http://identifiers.org/mesh/D011349 +property_value: exactMatch http://identifiers.org/snomedct/3951002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0033246 +property_value: exactMatch NCIT:C38011 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005545 +name: staphylococcus aureus infection +def: "An infectious process in which the bacteria Staphylococcus aureus is present." [NCIT:C122576] +xref: EFO:0005681 {source="MONDO:equivalentTo"} +xref: NCIT:C122576 {source="MONDO:equivalentTo"} +xref: SCTID:406602003 {source="MONDO:equivalentTo"} +is_a: MONDO:0024313 {source="MONDO:Redundant", source="NCIT:C122576"} ! staphylococcal infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:1280 ! Staphylococcus aureus +relationship: disease_has_infectious_agent NCBITaxon:1280 ! Staphylococcus aureus +property_value: exactMatch http://identifiers.org/snomedct/406602003 +property_value: exactMatch NCIT:C122576 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/infectious_disease_by_agent.yaml + +[Term] +id: MONDO:0005549 +name: renal cell adenocarcinoma +def: "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy." [EFO:0005708] +comment: Editor note: check relationship to RCC +synonym: "adenocarcinoma of kidney" EXACT [NCIT:C9385] +synonym: "adenocarcinoma of the kidney" EXACT [NCIT:C9385] +synonym: "carcinoma, renal cell, malignant" EXACT [NCIT:C9385] +synonym: "kidney adenocarcinoma" EXACT [NCIT:C9385] +synonym: "RCC" EXACT ABBREVIATION [NCIT:C9385] +synonym: "renal cell adenocarcinoma" EXACT [NCIT:C9385] +synonym: "renal cell cancer" EXACT [NCIT:C9385] +synonym: "renal cell carcinoma" BROAD [NCIT:C9385] +synonym: "renal cell carcinoma, stage unspecified" EXACT [NCIT:C9385] +xref: EFO:0005708 {source="MONDO:equivalentTo"} +xref: ICDO:8311/1 {source="NCIT:C9385"} +xref: ICDO:8312/3 {source="NCIT:C9385"} +xref: NCIT:C9385 {source="MONDO:equivalentTo"} +is_a: MONDO:0005086 ! renal cell carcinoma +property_value: exactMatch NCIT:C9385 + +[Term] +id: MONDO:0005550 +name: infectious disease +def: "A disorder directly resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact." [NCIT:C26726] +comment: Replaces 'infection' in disease hierarchy. OBI imported term infection is moved to pathologic process. This class is a container class for infectious diseases, not the process of infection itself. {source="EFO:0005741"} +synonym: "clinical infection" EXACT [NCIT:C26726] +synonym: "communicable disease" EXACT [doi:10.1007/978-1-4020-5614-7_3557, https://www.merriam-webster.com/medical/communicable%20disease] +synonym: "disease by infectious agent" RELATED [DOID:0050117] +synonym: "infection" EXACT [NCIT:C26726] +synonym: "infectious" EXACT [NCIT:C26726] +synonym: "infectious disease" EXACT [DOID:0050117, NCIT:C26726] +synonym: "infectious diseases and manifestations" EXACT [NCIT:C26726] +synonym: "infectious disorder" EXACT [NCIT:C26726] +synonym: "transmissible disease" EXACT [doi:10.1007/978-1-4020-5614-7_3557] +xref: DOID:0050117 {source="EFO:0005741", source="MONDO:equivalentTo"} +xref: EFO:0005741 {source="MONDO:equivalentTo"} +xref: ICD10CM:A00-B99 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:079.0 {source="DOID:0050117"} +xref: ICD9:136.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:136.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: IDO:0000436 {source="EFO:0005741"} +xref: MESH:D003141 {source="MONDO:equivalentTo"} +xref: NCIT:C26726 {source="MONDO:equivalentTo"} +xref: SCTID:40733004 {source="EFO:0005741", source="MONDO:equivalentTo"} +is_a: MONDO:0100336 ! infectious disease or post-infectious disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_infectious_agent NCBITaxon:1 ! root +relationship: disease_has_infectious_agent NCBITaxon:1 ! root +property_value: exactMatch DOID:0050117 +property_value: exactMatch http://identifiers.org/mesh/D003141 +property_value: exactMatch http://identifiers.org/snomedct/40733004 +property_value: exactMatch https://icd.codes/icd10cm/A00-B99 +property_value: exactMatch NCIT:C26726 + +[Term] +id: MONDO:0005551 +name: eye allergy +def: "An allergic disease involving a pathogenic inflammatory response in the camera-type eye." [MONDO:patterns/specific_inflammatory_disease_by_site] +xref: EFO:0005751 {source="MONDO:equivalentTo"} +is_a: MONDO:0005271 {source="EFO:0005751", source="MONDO:Entailed", source="MONDO:Redundant"} ! allergic disease +is_a: MONDO:0005328 {source="EFO:0005751", source="MONDO:Entailed"} ! eye disorder +intersection_of: MONDO:0005271 ! allergic disease +intersection_of: disease_has_location UBERON:0000019 ! camera-type eye + +[Term] +id: MONDO:0005552 +name: ocular vascular disorder +def: "A disorder that is caused by pathologic changes in the ocular vasculature." [NCIT:P378] +synonym: "disease of vasculature of eye" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vasculature of eye" EXACT [] +synonym: "disorder of vasculature of eye" EXACT [MONDO:patterns/location_top] +synonym: "ocular vascular disorder" EXACT [NCIT:C35664] +synonym: "vasculature of eye disease" EXACT [MONDO:patterns/location] +synonym: "vasculature of eye disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: EFO:0005753 {source="MONDO:equivalentTo"} +xref: NCIT:C35664 {source="EFO:0005753", source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="EFO:0005753", source="MONDO:Entailed", source="NCIT:C35664"} ! eye disorder +is_a: MONDO:0005385 ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002203 ! vasculature of eye +relationship: disease_has_location UBERON:0002203 ! vasculature of eye +property_value: exactMatch NCIT:C35664 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005554 +name: rheumatic disorder +def: "Inflammatory and degenerative diseases of connective tissue structures, such as arthritis." [NCIT:C27204] +comment: This is an umbrella term encompassing conditions causing chronic, often intermittent pain affecting the joints and/or connective tissue +synonym: "collagen disease" RELATED [NCIT:C27204] +synonym: "collagen vascular disease" RELATED [NCIT:C27204] +synonym: "connective tissue disease" RELATED [NCIT:C27204] +synonym: "disease, rheumatic" RELATED [MESH:D012216] +synonym: "diseases, rheumatic" RELATED [MESH:D012216] +synonym: "enthesopathies" RELATED [MESH:D012216] +synonym: "enthesopathy" RELATED [MESH:D012216] +synonym: "inflammatory rheumatism" RELATED [NCIT:C27204] +synonym: "musculoskeletal pain disorder" RELATED [NCIT:C27204] +synonym: "rheumatic disease" EXACT [MESH:D012216, NCIT:C27204] +synonym: "rheumatism" RELATED [MESH:D012216, NCIT:C27204] +synonym: "rheumatologic disorder" EXACT [NCIT:C27204] +xref: DOID:1575 {source="EFO:0005755", source="MONDO:equivalentTo"} +xref: EFO:0005755 {source="MONDO:equivalentTo"} +xref: ICD9:729.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012216 {source="MONDO:equivalentTo"} +xref: NCIT:C27204 {source="MONDO:equivalentTo"} +xref: SCTID:396332003 {source="EFO:0005755", source="MONDO:equivalentTo"} +xref: UMLS:C0035435 {source="MONDO:equivalentTo", source="NCIT:C27204"} +xref: Wikipedia:Rheumatism {source="EFO:0005755"} +is_a: MONDO:0003900 {source="DOID:1575", source="MESH:D012216"} ! connective tissue disorder +property_value: exactMatch DOID:1575 +property_value: exactMatch http://identifiers.org/mesh/D012216 +property_value: exactMatch http://identifiers.org/snomedct/396332003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035435 +property_value: exactMatch NCIT:C27204 +property_value: excluded_subClassOf MONDO:0000589 {source="DOID:1575"} +property_value: excluded_subClassOf MONDO:0002081 {source="MESH:D012216"} +property_value: excluded_subClassOf MONDO:0005046 {source="MONDO:Redundant", source="NCIT:C27204"} + +[Term] +id: MONDO:0005556 +name: lupus nephritis +def: "Glomerulonephritis in the context of systemic lupus erythematosus." [NCIT:C34789] +subset: gard_rare {source="GARD:0010747"} +synonym: "Glomerulonephritides, lupus" RELATED [MESH:D008181] +synonym: "glomerulonephritis, lupus" RELATED [MESH:D008181] +synonym: "lupus Glomerulonephritides" RELATED [MESH:D008181] +synonym: "lupus glomerulonephritis" EXACT [MESH:D008181, NCIT:C34789] +synonym: "lupus Nephritides" RELATED [MESH:D008181] +synonym: "lupus nephritis" EXACT [NCIT:C34789] +synonym: "Nephritides, lupus" RELATED [MESH:D008181] +synonym: "nephritis, lupus" RELATED [MESH:D008181] +synonym: "SLE nephritis" EXACT [NCIT:C34789] +xref: DOID:0080162 {source="MONDO:equivalentTo"} +xref: EFO:0005761 {source="MONDO:equivalentTo"} +xref: GARD:0010747 {source="MONDO:equivalentTo"} +xref: MESH:D008181 {source="DOID:0080162", source="EFO:0005761", source="MONDO:equivalentTo"} +xref: NCIT:C34789 {source="EFO:0005761", source="MONDO:equivalentTo"} +xref: SCTID:68815009 {source="MONDO:equivalentTo"} +xref: UMLS:C0024143 {source="MONDO:equivalentTo", source="NCIT:C34789", source="GARD:0010747"} +is_a: MONDO:0002462 {source="DOID:0080162", source="MESH:D008181", source="MONDO:Entailed", source="NCIT:C34789"} ! glomerulonephritis +intersection_of: MONDO:0002462 ! glomerulonephritis +intersection_of: disease_arises_from_feature MONDO:0007915 ! systemic lupus erythematosus +relationship: disease_arises_from_feature MONDO:0007915 ! systemic lupus erythematosus +property_value: exactMatch DOID:0080162 +property_value: exactMatch http://identifiers.org/mesh/D008181 +property_value: exactMatch http://identifiers.org/snomedct/68815009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024143 +property_value: exactMatch NCIT:C34789 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/10747/lupus-nephritis xsd:anyURI {source="GARD:0010747"} + +[Term] +id: MONDO:0005557 +name: calcium metabolic disease +def: "Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization." [MESH:D002128] +comment: Defined in terms of GO calcium ion homeostatis. Also consistent with HPO. Note advice from GO as calcium ions are neither created or destroyed is not metabolic process in terms of go, but name retained for purposes of consistency with e.g. Snomed and Mesh, Consider relocating this as a sibling of metabolic disease. {source="EFO:0005769"} +synonym: "calcium metabolism disease" RELATED [DOID:10575] +synonym: "calcium metabolism disorder" RELATED [] +synonym: "disorder of calcium metabolism" EXACT [] +xref: DOID:10575 {source="MONDO:equivalentTo", source="EFO:0005769"} +xref: EFO:0005769 {source="MONDO:equivalentTo"} +xref: ICD9:275.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0005769", source="DOID:10575"} +xref: ICD9:275.40 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0005769", source="DOID:10575"} +xref: ICD9:275.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D002128 {source="MONDO:equivalentTo", source="EFO:0005769", source="DOID:10575"} +xref: SCTID:71638002 {source="MONDO:equivalentTo", source="EFO:0005769", source="DOID:10575"} +xref: UMLS:C0006705 {source="MONDO:equivalentTo", source="EFO:0005769", source="DOID:10575"} +is_a: MONDO:0000226 {source="DOID:10575"} ! mineral metabolism disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_disrupts GO:0055074 ! calcium ion homeostasis +relationship: disease_disrupts GO:0055074 {source="EFO:0005769-modified"} ! calcium ion homeostasis +property_value: exactMatch DOID:10575 +property_value: exactMatch http://identifiers.org/mesh/D002128 +property_value: exactMatch http://identifiers.org/snomedct/71638002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006705 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0005558 +name: ovarian disorder +def: "A disease involving the ovary." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of ovary" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ovary" EXACT [] +synonym: "disorder of ovary" EXACT [MONDO:patterns/location_top] +synonym: "ovarian disease" EXACT [NCIT:C26841] +synonym: "ovarian disorder" EXACT [NCIT:C26841] +synonym: "ovary disease" EXACT [MONDO:patterns/location] +synonym: "ovary disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1100 {source="MONDO:equivalentTo", source="EFO:0005771"} +xref: EFO:0005771 {source="MONDO:equivalentTo"} +xref: MESH:D010049 {source="DOID:1100", source="MONDO:equivalentTo"} +xref: NCIT:C26841 {source="DOID:1100", source="MONDO:equivalentTo", source="EFO:0005771"} +xref: SCTID:5552004 {source="DOID:1100", source="MONDO:equivalentTo"} +xref: UMLS:C0029928 {source="DOID:1100", source="MONDO:equivalentTo", source="NCIT:C26841"} +is_a: MONDO:0002259 {source="DOID:1100", source="MESH:D010049", source="MONDO:Redundant"} ! gonadal disorder +is_a: MONDO:0002263 {source="DOID:1100", source="MESH:D010049/inferred", source="MONDO:Redundant", source="NCIT:C26841"} ! female reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000992 ! ovary +relationship: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:1100 +property_value: exactMatch http://identifiers.org/mesh/D010049 +property_value: exactMatch http://identifiers.org/snomedct/5552004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029928 +property_value: exactMatch NCIT:C26841 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005559 +name: neurodegenerative disease +def: "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function." [NCIT:C4802] +comment: Editor notes: DO treats this as two diseases +subset: merged_class +synonym: "brain degeneration" EXACT [DOID:1443] +synonym: "central nervous system degenerative disorder" EXACT [MONDO:patterns/location, NCIT:C4802] +synonym: "central nervous system neurodegenerative disorder" EXACT [NCIT:C4802] +synonym: "cerebral degeneration disease" NARROW [MONDO:0001963] +synonym: "degenerative disease" BROAD [DOID:1289] +synonym: "degenerative disorder of central nervous system" EXACT [MONDO:design_pattern] +synonym: "neurodegenerative disease" EXACT [DOID:1289, NCIT:C4802] +xref: DOID:1289 {source="EFO:0005772", source="MONDO:equivalentTo"} +xref: EFO:0005772 {source="MONDO:equivalentTo"} +xref: ICD9:349.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D019636 {source="EFO:0005772", source="DOID:1289", source="MONDO:equivalentTo"} +xref: NCIT:C4802 {source="EFO:0005772", source="MONDO:equivalentTo"} +xref: SCTID:80690008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002602 {source="https://github.com/monarch-initiative/mondo/issues/528", source="https://orcid.org/0000-0001-5208-3432"} ! central nervous system disorder +relationship: disease_has_major_feature HP:0007313 ! Cerebral degeneration +property_value: exactMatch DOID:1289 +property_value: exactMatch http://identifiers.org/mesh/D019636 +property_value: exactMatch http://identifiers.org/snomedct/80690008 +property_value: exactMatch NCIT:C4802 + +[Term] +id: MONDO:0005560 +name: brain disorder +def: "A disease affecting the brain or part of the brain." [EFO:0005774] +comment: Editor note: NCIT has different classes for brain disease and encephalopathy +synonym: "brain disease" EXACT [MONDO:patterns/location] +synonym: "brain disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of brain" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of brain" EXACT [] +synonym: "disorder of brain" EXACT [MONDO:patterns/location_top] +synonym: "encephalopathy" NARROW [DOID:936, NCIT:C26920] +xref: DOID:936 {source="EFO:0005774", source="MONDO:equivalentTo"} +xref: EFO:0005774 {source="MONDO:equivalentTo"} +xref: ICD9:348.3 {source="DOID:936", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:348.30 {source="DOID:936", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:348.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:348.9 {source="DOID:936", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001927 {source="DOID:936", source="MONDO:equivalentTo"} +xref: NCIT:C96413 {source="DOID:936", source="MONDO:equivalentTo"} +xref: SCTID:81308009 {source="DOID:936", source="MONDO:equivalentTo"} +xref: UMLS:C0006111 {source="DOID:936", source="MONDO:equivalentTo"} +xref: UMLS:C0085584 {source="DOID:936", source="MONDO:equivalentTo", source="NCIT:C26920"} +is_a: MONDO:0002602 {source="DOID:936", source="MESH:D001927", source="MONDO:Redundant", source="NCIT:C26920/inferred"} ! central nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000955 ! brain +relationship: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch DOID:936 +property_value: exactMatch http://identifiers.org/mesh/D001927 +property_value: exactMatch http://identifiers.org/snomedct/81308009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006111 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085584 +property_value: exactMatch NCIT:C96413 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005561 +name: aortic disorder +def: "Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)" [NCIT:P378] +synonym: "aorta disease" EXACT [MONDO:patterns/location] +synonym: "aorta disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "aortic disorder" EXACT [DOID:520] +synonym: "disease of aorta" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of aorta" EXACT [] +synonym: "disorder of aorta" EXACT [MONDO:patterns/location_top] +synonym: "disorder of the aorta" EXACT [DOID:520] +xref: DOID:520 {source="EFO:0005775", source="MONDO:equivalentTo"} +xref: EFO:0005775 {source="MONDO:equivalentTo"} +xref: ICD9:447.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D001018 {source="MONDO:equivalentTo", source="DOID:520"} +xref: NCIT:C101253 {source="MONDO:equivalentTo", source="DOID:520"} +xref: SCTID:47040006 {source="MONDO:equivalentTo", source="DOID:520"} +xref: UMLS:C0003493 {source="MONDO:equivalentTo", source="DOID:520"} +is_a: MONDO:0000473 {source="DOID:520", source="NCIT:C101253"} ! arterial disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000947 ! aorta +relationship: disease_has_location UBERON:0000947 ! aorta +property_value: exactMatch DOID:520 +property_value: exactMatch http://identifiers.org/mesh/D001018 +property_value: exactMatch http://identifiers.org/snomedct/47040006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003493 +property_value: exactMatch NCIT:C101253 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005564 +name: embryonal neoplasm +def: "A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues. Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003" [NCIT:C3264] +synonym: "embryo neoplasm" EXACT [DOID:688] +synonym: "embryonal cancer" RELATED [DOID:688] +synonym: "embryonal neoplasm" EXACT [NCIT:C3264] +synonym: "embryonal tumor" EXACT [NCIT:C3264] +synonym: "EMBT" RELATED ABBREVIATION [ONCOTREE:EMBT] +xref: DOID:688 {source="MONDO:equivalentTo"} +xref: EFO:0005784 {source="MONDO:equivalentTo"} +xref: NCIT:C3264 {source="EFO:0005784", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:EMBT {source="MONDO:equivalentTo"} +xref: UMLS:C0027654 {source="DOID:688", source="NCIT:C3264", source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="DOID:688/inferred", source="EFO:0005784", source="NCIT:C3264/inferred"} ! neoplasm +property_value: exactMatch DOID:688 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027654 +property_value: exactMatch NCIT:C3264 + +[Term] +id: MONDO:0005570 +name: hematologic disorder +def: "A disease involving the hematopoietic system." [https://orcid.org/0000-0002-6601-2165] +comment: placeholder for lymphoid disease {source="EFO:0005803"} +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:97992"} +synonym: "blood disease" EXACT [DOID:74] +synonym: "blood disorder" EXACT [DOID:74, NCIT:C26323] +synonym: "blood dyscrasia" EXACT [DOID:74] +synonym: "disease of hematopoietic system" EXACT [DOID:74, MONDO:patterns/location_top] +synonym: "disease of the blood and blood-forming organs" EXACT [DOID:74, ICD9CM:280-289.99] +synonym: "disease or disorder of hematopoietic system" EXACT [] +synonym: "disorder of hematopoietic system" EXACT [MONDO:patterns/location_top] +synonym: "hematologic and lymphocytic disorder" EXACT [NCIT:C26323] +synonym: "hematologic disorder" EXACT [NCIT:C26323] +synonym: "hematological disease" EXACT [DOID:74, MTH:NOCODE] +synonym: "hematological disorder" EXACT [MONDO:cjm, NCIT:C26323] +synonym: "hematological disorders and malignancies" RELATED [GTR:AN1320635] +synonym: "hematological system disease" EXACT [https://orcid.org/0000-0002-0736-9199] +synonym: "hematopoietic disease" EXACT [DOID:74] +synonym: "hematopoietic system disease" EXACT [MONDO:patterns/location] +synonym: "hematopoietic system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "rare hematologic disease" EXACT [MONDO:0020006] +xref: DOID:74 {source="MONDO:equivalentTo", source="EFO:0005803"} +xref: EFO:0005803 {source="MONDO:equivalentTo"} +xref: GTR:AN1320635 {source="UMLS:CN882913"} +xref: ICD10CM:D50-D89 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:280-289.99 {source="DOID:74"} +xref: ICD9:289.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:289.9 {source="DOID:74", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D006402 {source="DOID:74", source="MONDO:equivalentTo", source="EFO:0005803"} +xref: NCIT:C26323 {source="DOID:74", source="MONDO:equivalentTo"} +xref: Orphanet:97992 {source="MONDO:equivalentTo"} +xref: SCTID:414022008 {source="MONDO:equivalentTo"} +xref: UMLS:C0018939 {source="DOID:74", source="MONDO:equivalentTo", source="NCIT:C26323"} +xref: UMLS:CN206939 {source="MONDO:equivalentTo"} +xref: UMLS:CN882913 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002390 ! hematopoietic system +relationship: disease_has_location UBERON:0002390 ! hematopoietic system +relationship: has_modifier MONDO:0021136 ! rare +property_value: exactMatch DOID:74 +property_value: exactMatch http://identifiers.org/mesh/D006402 +property_value: exactMatch http://identifiers.org/snomedct/414022008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018939 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206939 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN882913 +property_value: exactMatch https://icd.codes/icd10cm/D50-D89 +property_value: exactMatch NCIT:C26323 +property_value: exactMatch Orphanet:97992 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/254 xsd:anyURI + +[Term] +id: MONDO:0005574 +name: tauopathy +def: "Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (tau proteins) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with alzheimer disease; dementia; parkinsonian disorders; progressive supranuclear palsy (supranuclear palsy, progressive); and corticobasal degeneration." [MESH:D024801] +xref: DOID:680 {source="MONDO:equivalentTo", source="EFO:0005815"} +xref: EFO:0005815 {source="MONDO:equivalentTo"} +xref: MESH:D024801 {source="MONDO:equivalentTo", source="DOID:680"} +xref: UMLS:C0949664 {source="MONDO:equivalentTo", source="DOID:680"} +is_a: MONDO:0005559 {source="DOID:680", source="EFO:0005815", source="MESH:D024801"} ! neurodegenerative disease +relationship: disease_has_feature HP:0002185 ! Neurofibrillary tangles +property_value: exactMatch DOID:680 +property_value: exactMatch http://identifiers.org/mesh/D024801 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0949664 + +[Term] +id: MONDO:0005575 +name: colorectal cancer +def: "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C4978] +comment: Editor note: some sources make distinct classes for colorectal vs large intestine. We follow NCIT and make these equivalent +subset: clingen +synonym: "cancer of colorectum" EXACT [MONDO:patterns/cancer] +synonym: "cancer of large bowel" EXACT [NCIT:C2955] +synonym: "cancer of large intestine" EXACT [NCIT:C2955] +synonym: "cancer of the large bowel" EXACT [NCIT:C2955] +synonym: "colon cancer" RELATED [OMIM:114500] +synonym: "colon cancer, advanced, somatic" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colon cancer, somatic" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colon cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colorectal cancer" EXACT [MONDO:Lexical, OMIM:114500] +synonym: "colorectal cancer with chromosomal instability, somatic" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colorectal cancer, autosomal dominant, somatic mutation" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colorectal cancer, somatic" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:114500, OMIM:genemap2] +synonym: "colorectum cancer" EXACT [MONDO:patterns/location] +synonym: "CRC" RELATED ABBREVIATION [MONDO:Lexical, OMIM:114500] +synonym: "large intestine cancer" RELATED [DOID:5672] +synonym: "malignant colorectal neoplasm" EXACT [NCIT:C4978] +synonym: "malignant colorectal tumor" EXACT [NCIT:C4978] +synonym: "malignant colorectum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant large bowel neoplasm" EXACT [NCIT:C4978] +synonym: "malignant large bowel tumor" EXACT [NCIT:C4978] +synonym: "malignant large intestine neoplasm" EXACT [NCIT:C4978] +synonym: "malignant large intestine tumor" EXACT [NCIT:C4978] +synonym: "malignant neoplasm of colorectum" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of large bowel" EXACT [NCIT:C4978] +synonym: "malignant neoplasm of large intestine" EXACT [NCIT:C4978] +synonym: "malignant neoplasm of the large bowel" EXACT [NCIT:C4978] +synonym: "malignant neoplasm of the large intestine" EXACT [NCIT:C4978] +synonym: "malignant tumor of large bowel" EXACT [NCIT:C4978] +synonym: "malignant tumor of large intestine" EXACT [NCIT:C4978] +synonym: "malignant tumor of the large bowel" EXACT [NCIT:C4978] +synonym: "malignant tumor of the large intestine" EXACT [NCIT:C4978] +xref: DOID:5672 {source="MONDO:equivalentTo"} +xref: DOID:9256 {source="EFO:0005842", source="MONDO:equivalentTo"} +xref: EFO:0005842 {source="MONDO:equivalentTo"} +xref: KEGG:05210 {source="MONDO:relatedTo", source="DOID:9256"} +xref: NCIT:C4978 {source="EFO:0005842", source="MONDO:equivalentTo", source="DOID:5672"} +xref: OMIM:114500 {source="MONDO:equivalentTo", source="DOID:9256"} +xref: Orphanet:466667 {source="MONDO:equivalentTo"} +xref: SCTID:363510005 {source="MONDO:equivalentTo", source="DOID:5672"} +xref: UMLS:C1527249 {source="MONDO:equivalentObsolete", source="OMIM:114500", source="DOID:9256"} +is_a: MONDO:0005335 {source="MONDO:Redundant", source="NCIT:C4978"} ! colorectal neoplasm +is_a: MONDO:0005814 {source="DOID:5672", source="DOID:9256/inferred", source="MONDO:Redundant", source="NCIT:C4978"} ! intestinal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0012652 ! colorectum +property_value: exactMatch DOID:5672 +property_value: exactMatch DOID:9256 +property_value: exactMatch http://identifiers.org/snomedct/363510005 +property_value: exactMatch https://omim.org/entry/114500 +property_value: exactMatch NCIT:C4978 +property_value: exactMatch Orphanet:466667 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0005578 +name: arthritic joint disease +def: "An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain." [NCIT:C2883] +comment: Editor note: osteoarthritis is primarily non-inflammatory which causes issues if we classify arthritis as inflammatory. +synonym: "arthritis" EXACT [DOID:848, NCIT:C2883] +synonym: "inflammation of skeletal joint" EXACT [] +synonym: "inflammatory disorder of joint" NARROW [DOID:848] +synonym: "skeletal joint inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:848 {source="EFO:0005856", source="MONDO:equivalentTo"} +xref: EFO:0005856 {source="MONDO:equivalentTo"} +xref: MESH:D001168 {source="DOID:848", source="EFO:0005856", source="MONDO:equivalentTo"} +xref: NCIT:C2883 {source="DOID:848", source="EFO:0005856", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:3723001 {source="DOID:848", source="EFO:0005856", source="MONDO:equivalentTo"} +xref: UMLS:C0003864 {source="DOID:848", source="MONDO:equivalentTo", source="NCIT:C2883"} +xref: Wikipedia:Arthritis {source="EFO:0005856"} +is_a: MONDO:0002614 {source="DOID:848", source="MONDO:Redundant"} ! bone inflammation disease +is_a: MONDO:0006816 {source="MESH:D001168", source="MONDO:Redundant", source="NCIT:C2883"} ! arthropathy +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000982 ! skeletal joint +relationship: disease_has_feature HP:0002829 ! Arthralgia +relationship: disease_has_inflammation_site UBERON:0000982 ! skeletal joint +property_value: exactMatch DOID:848 +property_value: exactMatch http://identifiers.org/mesh/D001168 +property_value: exactMatch http://identifiers.org/snomedct/3723001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003864 +property_value: exactMatch NCIT:C2883 +property_value: excluded_subClassOf MONDO:0005554 {source="EFO:0005856"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005579 +name: epilepsy, idiopathic generalized +def: "A chronic condition characterised by recurrent generalised seizures." [NCIT:P378] +synonym: "EIG" EXACT ABBREVIATION [MONDO:cjm] +synonym: "epilepsy, idiopathic generalized" EXACT [MONDO:Lexical, OMIM:600669] +synonym: "generalised epilepsy" EXACT [DOID:1827] +synonym: "generalized epilepsy" EXACT [NCIT:C3021] +synonym: "idiopathic generalized epilepsy" RELATED [DOID:1827, OMIM:600669] +xref: DOID:1827 {source="MONDO:equivalentTo", source="EFO:0005917"} +xref: EFO:0005917 {source="MONDO:equivalentTo"} +xref: MESH:C562694 {source="MONDO:equivalentTo"} +xref: NCIT:C3021 {source="MONDO:equivalentTo", source="DOID:1827"} +xref: OMIMPS:600669 {source="MONDO:equivalentTo"} +xref: SCTID:19598007 {source="MONDO:equivalentTo", source="DOID:1827"} +is_a: MONDO:0005027 {source="DOID:1827", source="EFO:0005917", source="MESH:D004829", source="NCIT:C3021"} ! epilepsy +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0700007 ! idiopathic disease +intersection_of: MONDO:0005027 ! epilepsy +intersection_of: has_modifier MONDO:0700005 ! idiopathic +property_value: exactMatch DOID:1827 +property_value: exactMatch http://identifiers.org/mesh/C562694 +property_value: exactMatch http://identifiers.org/snomedct/19598007 +property_value: exactMatch https://omim.org/phenotypicSeries/PS600669 +property_value: exactMatch NCIT:C3021 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0005580 +name: esophageal squamous cell carcinoma +def: "Esophageal squamous cell carcinoma (ESCC) is a type of esophageal carcinoma (EC) that can affect any part of the esophagus, but is usually located in the upper or middle third." [Orphanet:99977] +subset: ordo_disease {source="Orphanet:99977"} +synonym: "ESCC" EXACT ABBREVIATION [NCIT:C4024, ONCOTREE:ESCC, Orphanet:99977] +synonym: "esophageal epidermoid carcinoma" EXACT [NCIT:C4024, Orphanet:99977] +synonym: "esophageal scc" EXACT [NCIT:C4024] +synonym: "esophageal squamous cell cancer" EXACT [NCIT:C4024] +synonym: "esophageal squamous cell carcinoma" EXACT [NCIT:C4024, Orphanet:99977] +synonym: "esophagus scc" EXACT [NCIT:C4024] +synonym: "esophagus squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4024] +synonym: "scc of esophagus" EXACT [DOID:3748, NCIT:C4024] +synonym: "scc of the esophagus" EXACT [NCIT:C4024] +synonym: "squamous cell car. - esophagus" EXACT [NCIT:C4024] +synonym: "squamous cell carcinoma of esophagus" EXACT [DOID:3748, NCIT:C4024] +synonym: "squamous cell carcinoma of the esophagus" EXACT [NCIT:C4024] +xref: DOID:3748 {source="EFO:0005922", source="MONDO:equivalentTo"} +xref: EFO:0005922 {source="MONDO:equivalentTo"} +xref: ICD10CM:C15.3 {source="Orphanet:99977/btnt", source="Orphanet:99977"} +xref: ICD10CM:C15.4 {source="Orphanet:99977/btnt", source="Orphanet:99977"} +xref: MESH:C562729 {source="EFO:0005922", source="MONDO:equivalentTo", source="DOID:3748"} +xref: NCIT:C4024 {source="EFO:0005922", source="MONDO:equivalentTo", source="DOID:3748", source="MONDO:exact-label-match"} +xref: OMIM:133239 {source="Orphanet:99977/ntbt", source="Orphanet:99977", source="EFO:0005922"} +xref: ONCOTREE:ESCC {source="MONDO:equivalentTo"} +xref: Orphanet:99977 {source="MONDO:equivalentTo"} +xref: SCTID:276804009 {source="MONDO:equivalentTo", source="DOID:3748"} +xref: UMLS:C0279626 {source="Orphanet:99977", source="EFO:0005922", source="MONDO:equivalentTo", source="NCIT:C4024", source="DOID:3748"} +is_a: MONDO:0005096 {source="DOID:3748", source="EFO:0005922", source="MESH:C562729", source="MONDO:Redundant", source="NCIT:C4024"} ! squamous cell carcinoma +is_a: MONDO:0019086 {source="DOID:3748", source="EFO:0005922", source="MONDO:Redundant", source="NCIT:C4024", source="Orphanet:99977"} ! carcinoma of esophagus +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: broadMatch https://icd.codes/icd10cm/C15.3 +property_value: broadMatch https://icd.codes/icd10cm/C15.4 +property_value: exactMatch DOID:3748 +property_value: exactMatch http://identifiers.org/mesh/C562729 +property_value: exactMatch http://identifiers.org/snomedct/276804009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279626 +property_value: exactMatch NCIT:C4024 +property_value: exactMatch Orphanet:99977 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0005586 +name: head and neck neoplasm +def: "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." [NCIT:C3077] +synonym: "craniocervical region neoplasm" EXACT [] +synonym: "craniocervical region neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "craniocervical region tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "head and neck neoplasm" EXACT [NCIT:C3077] +synonym: "head and neck neoplasm (excluding central nervous system)" EXACT [NCIT:C3077] +synonym: "head and neck tumor" EXACT [NCIT:C3077] +synonym: "neoplasm of craniocervical region" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of head and neck" EXACT [NCIT:C3077] +synonym: "neoplasm of the head and neck" EXACT [NCIT:C3077] +synonym: "tumor of craniocervical region" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of head and neck" EXACT [NCIT:C3077] +synonym: "tumor of the head and neck" EXACT [NCIT:C3077] +xref: EFO:0005950 {source="MONDO:equivalentTo"} +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3077 {source="EFO:0005950", source="MONDO:equivalentTo"} +xref: ONCOTREE:HEADNECK {source="MONDO:equivalentTo"} +xref: SCTID:255055008 {source="EFO:0005950", source="MONDO:equivalentTo"} +xref: UMLS:C0018671 {source="NCIT:C3077", source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C3077/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0007811 ! craniocervical region +relationship: disease_has_location UBERON:0007811 ! craniocervical region +property_value: exactMatch http://identifiers.org/snomedct/255055008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018671 +property_value: exactMatch NCIT:C3077 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005590 +name: breast ductal adenocarcinoma +def: "A breast carcinoma arising from the ducts. While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast. Ductal carcinomas account for about two thirds of all breast cancers. Two types of ductal carcinomas have been described: ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. The latter often spreads to the axillary lymph nodes and other anatomic sites. The two forms of ductal carcinoma often coexist." [NCIT:C4017] +synonym: "breast ductal carcinoma" EXACT [MONDO:0002484] +synonym: "duct adenocarcinoma" BROAD [NCIT:C4017] +synonym: "duct carcinoma" BROAD [NCIT:C4017] +synonym: "ductal adenocarcinoma" BROAD [NCIT:C4017] +synonym: "ductal breast adenocarcinoma" EXACT [MONDO:0005022] +synonym: "ductal breast carcinoma" EXACT [NCIT:C4017] +synonym: "ductal carcinoma" BROAD [NCIT:C4017] +synonym: "ductal carcinoma of breast" EXACT [NCIT:C4017] +synonym: "ductal carcinoma of the breast" EXACT [NCIT:C4017] +synonym: "mammary duct adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3007 {source="MONDO:equivalentTo"} +xref: EFO:0006318 {source="MONDO:equivalentTo"} +xref: MESH:D018270 {source="MONDO:equivalentTo"} +xref: NCIT:C4017 {source="EFO:0000430", source="EFO:0006318", source="MONDO:equivalentTo"} +is_a: MONDO:0004988 {source="MONDO:Redundant", source="NCIT:C4017"} ! breast adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001765 ! mammary duct +relationship: disease_has_location UBERON:0001765 ! mammary duct +property_value: exactMatch DOID:3007 +property_value: exactMatch http://identifiers.org/mesh/D018270 +property_value: exactMatch NCIT:C4017 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0005593 +name: chronic periodontitis +def: "A chronic inflammatory process that affects the tissues that surround and support the teeth." [NCIT:P378] +synonym: "periodontitis, chronic" EXACT [MONDO:patterns/chronic] +xref: EFO:0006343 {source="MONDO:equivalentTo"} +xref: ICD10CM:K05.3 {source="MONDO:equivalentTo"} +xref: ICD9:523.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0006343"} +xref: ICD9:523.40 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D055113 {source="MONDO:equivalentTo", source="EFO:0006343"} +xref: NCIT:C35326 {source="MONDO:equivalentTo", source="EFO:0006343"} +xref: SCTID:5689008 {source="MONDO:equivalentTo", source="EFO:0006343"} +is_a: MONDO:0005076 {source="EFO:0006343", source="MESH:D055113", source="MONDO:Redundant", source="NCIT:C35326"} ! periodontitis +intersection_of: MONDO:0005076 ! periodontitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/mesh/D055113 +property_value: exactMatch http://identifiers.org/snomedct/5689008 +property_value: exactMatch https://icd.codes/icd10cm/K05.3 +property_value: exactMatch NCIT:C35326 + +[Term] +id: MONDO:0005595 +name: laryngeal squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx." [NCIT:C4044] +subset: ordo_disease +synonym: "epidermoid carcinoma of larynx" EXACT [NCIT:C4044] +synonym: "epidermoid carcinoma of the larynx" EXACT [DOID:2876, NCIT:C4044] +synonym: "laryngeal epidermoid carcinoma" EXACT [NCIT:C4044] +synonym: "laryngeal squamous cell carcinoma" EXACT [NCIT:C4044] +synonym: "laryngeal throat squamous cell cancer" EXACT [NCIT:C4044] +synonym: "larynx epidermoid carcinoma" EXACT [NCIT:C4044] +synonym: "larynx squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4044] +synonym: "LXSC" RELATED ABBREVIATION [ONCOTREE:LXSC] +synonym: "squamous cell carcinoma of larynx" EXACT [NCIT:C4044] +synonym: "squamous cell carcinoma of the larynx" EXACT [NCIT:C4044] +xref: DOID:2876 {source="MONDO:equivalentTo", source="EFO:0006352"} +xref: EFO:0006352 {source="MONDO:equivalentTo"} +xref: NCIT:C4044 {source="MONDO:equivalentTo", source="DOID:2876", source="MONDO:exact-label-match", source="EFO:0006352"} +xref: ONCOTREE:LXSC {source="MONDO:equivalentTo"} +xref: Orphanet:494550 {source="MONDO:equivalentTo"} +xref: SCTID:405822008 {source="MONDO:equivalentTo", source="DOID:2876", source="EFO:0006352"} +xref: UMLS:C0280324 {source="NCIT:C4044", source="MONDO:equivalentTo", source="DOID:2876"} +is_a: MONDO:0002358 {source="DOID:2876", source="MONDO:Redundant", source="NCIT:C4044"} ! laryngeal carcinoma +is_a: MONDO:0010150 {source="EFO:0006352", source="NCIT:C4044", source="ONCOTREE:LXSC"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch DOID:2876 +property_value: exactMatch http://identifiers.org/snomedct/405822008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280324 +property_value: exactMatch NCIT:C4044 +property_value: exactMatch Orphanet:494550 +property_value: excluded_subClassOf MONDO:0020035 {source="Orphanet:494550"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0005605 +name: transitional cell papilloma +def: "A benign papillary neoplasm composed of transitional cells which show preservation of the nuclear polarity." [NCIT:C4115] +synonym: "papilloma, transitional cell, benign" EXACT [NCIT:C4115] +synonym: "transitional cell papilloma" EXACT [DOID:2670, NCIT:C4115] +synonym: "transitional cell papilloma NOS (morphologic abnormality)" EXACT [DOID:2670] +synonym: "transitional cell papilloma, benign" EXACT [DOID:2670] +synonym: "transitional cell papilloma, benign (morphologic abnormality)" EXACT [DOID:2670] +synonym: "transitional papilloma" EXACT [NCIT:C4115] +xref: DOID:2670 {source="MONDO:equivalentTo", source="EFO:0006497"} +xref: EFO:0006497 {source="MONDO:equivalentTo"} +xref: ICDO:8120/0 {source="NCIT:C4115"} +xref: NCIT:C4115 {source="DOID:2670", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:0006497"} +xref: UMLS:C0334266 {source="DOID:2670", source="MONDO:equivalentTo", source="NCIT:C4115"} +is_a: MONDO:0002363 {source="DOID:2670", source="MONDO:Redundant", source="NCIT:C4115"} ! papilloma +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_arises_from_structure CL:1001428 ! bladder urothelial cell +relationship: disease_arises_from_structure CL:1001428 ! bladder urothelial cell +relationship: disease_arises_from_structure UBERON:0004645 {source="NCIT:C4115"} ! urinary bladder urothelium +property_value: exactMatch DOID:2670 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334266 +property_value: exactMatch NCIT:C4115 + +[Term] +id: MONDO:0005607 +name: chronic bronchitis +def: "A type of chronic obstructive pulmonary disease characterized by chronic inflammation in the bronchial tree that results in edema, mucus production, obstruction, and reduced airflow to and from the lung alveoli. The most common cause is tobacco smoking. Signs and symptoms include coughing with excessive mucus production, and shortness of breath." [NCIT:C26722] +synonym: "bronchitis, chronic" EXACT [MONDO:patterns/chronic] +xref: EFO:0006505 {source="MONDO:equivalentTo"} +xref: ICD9:491 {source="EFO:0006505"} +xref: ICD9:491.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:491.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D029481 {source="MONDO:equivalentTo"} +xref: NCIT:C26722 {source="EFO:0006505", source="MONDO:equivalentTo"} +xref: SCTID:63480004 {source="EFO:0006505", source="MONDO:equivalentTo"} +xref: UMLS:C0008677 {source="MONDO:equivalentTo", source="NCIT:C26722"} +is_a: MONDO:0003781 {source="MONDO:Redundant", source="NCIT:C26722"} ! bronchitis +is_a: MONDO:0005002 {source="EFO:0006505", source="NCIT:C26722"} ! chronic obstructive pulmonary disease +intersection_of: MONDO:0003781 ! bronchitis +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/mesh/D029481 +property_value: exactMatch http://identifiers.org/snomedct/63480004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008677 +property_value: exactMatch NCIT:C26722 + +[Term] +id: MONDO:0005611 +name: bladder transitional cell carcinoma +def: "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival." [NCIT:P378] +synonym: "bladder transitional cell carcinoma" EXACT [DOID:4006, NCIT:C39851] +synonym: "bladder urothelial cancer" EXACT [NCIT:C39851] +synonym: "bladder urothelial carcinoma" EXACT [NCIT:C39851] +synonym: "BLCA" RELATED ABBREVIATION [ONCOTREE:BLCA] +synonym: "transitional cell carcinoma of bladder" EXACT [DOID:4006] +synonym: "transitional cell carcinoma of the urinary bladder" EXACT [NCIT:C39851] +synonym: "urinary bladder transitional cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C39851] +synonym: "urinary bladder urothelial carcinoma" EXACT [DOID:4006, NCIT:C39851] +synonym: "urothelial bladder carcinoma" EXACT [DOID:4006] +synonym: "urothelial carcinoma of the urinary bladder" EXACT [NCIT:C39851] +xref: DOID:4006 {source="EFO:0006544", source="MONDO:equivalentTo"} +xref: EFO:0006544 {source="MONDO:equivalentTo"} +xref: NCIT:C39851 {source="EFO:0006544", source="DOID:4006", source="MONDO:equivalentTo"} +xref: ONCOTREE:BLCA {source="MONDO:equivalentTo"} +xref: SCTID:255109008 {source="DOID:4006", source="MONDO:equivalentTo"} +xref: UMLS:C0279680 {source="EFO:0006544", source="DOID:4006", source="NCIT:C39851", source="MONDO:equivalentTo"} +is_a: MONDO:0004986 {source="DOID:4006", source="EFO:0006544", source="MONDO:Redundant", source="NCIT:C39851"} ! urinary bladder carcinoma +is_a: MONDO:0040679 ! urothelial carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:4006 +property_value: exactMatch http://identifiers.org/snomedct/255109008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279680 +property_value: exactMatch NCIT:C39851 + +[Term] +id: MONDO:0005613 +name: mesonephric adenocarcinoma +def: "An adenocarcinoma of the cervix or the vagina arising from mesonephric remnants." [NCIT:C4072] +synonym: "malignant mesonephroma" EXACT [NCIT:C4072] +xref: EFO:0006719 {source="MONDO:equivalentTo"} +xref: ICDO:9110/3 {source="NCIT:C4072"} +xref: NCIT:C4072 {source="MONDO:equivalentTo", source="EFO:0006719"} +is_a: MONDO:0004970 {source="EFO:0006719", source="NCIT:C4072"} ! adenocarcinoma +property_value: exactMatch NCIT:C4072 + +[Term] +id: MONDO:0005623 +name: autoimmune thyroid disease +def: "Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis." [MESH:D013967] +comment: Disease of the thyroid gland due to autoimmunity in which the patient's immune system attacks and damages their thyroid. It can be either hyper- or hypothyroidism. (http://www.medicinenet.com/script/main/art.asp?articlekey=24314 - accessed 20th July, 2015) {source="EFO:0006812"} +synonym: "autoimmune thyroid gland inflammation" EXACT [] +synonym: "autoimmune thyroiditides" RELATED [MESH:D013967] +synonym: "autoimmune thyroiditis" RELATED [MESH:D013967] +synonym: "lymphocytic thyroiditides" RELATED [MESH:D013967] +synonym: "lymphocytic thyroiditis" RELATED [MESH:D013967] +synonym: "lymphomatous thyroiditides" RELATED [MESH:D013967] +synonym: "lymphomatous thyroiditis" RELATED [MESH:D013967] +synonym: "thyroiditides, autoimmune" RELATED [MESH:D013967] +synonym: "thyroiditides, lymphocytic" RELATED [MESH:D013967] +synonym: "thyroiditides, lymphomatous" RELATED [MESH:D013967] +synonym: "thyroiditis, lymphocytic" RELATED [MESH:D013967] +synonym: "thyroiditis, lymphomatous" RELATED [MESH:D013967] +xref: EFO:0006812 {source="MONDO:equivalentTo"} +xref: GARD:0006945 {source="MONDO:equivalentTo"} +xref: MESH:D013967 {source="MONDO:equivalentTo", source="EFO:0006812"} +xref: Wikipedia:Autoimmune_thyroiditis {source="EFO:0006812"} +is_a: MONDO:0000569 ! autoimmune disorder of endocrine system +is_a: MONDO:0004126 {source="MESH:D013967", source="MONDO:Redundant"} ! thyroiditis +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_inflammation_site UBERON:0002046 ! thyroid gland +property_value: exactMatch http://identifiers.org/mesh/D013967 +property_value: http://purl.org/dc/terms/conformsTo autoimmune:inflammation.yaml + +[Term] +id: MONDO:0005626 +name: epithelial neoplasm +def: "A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas." [NCIT:C3709] +synonym: "epithelial neoplasm" EXACT [NCIT:C3709] +synonym: "epithelioma" EXACT [NCIT:C3709] +xref: EFO:0006858 {source="MONDO:equivalentTo"} +xref: MESH:D009375 {source="MONDO:equivalentTo"} +xref: NCIT:C3709 {source="MONDO:equivalentTo", source="EFO:0006858"} +xref: SCTID:118285006 {source="MONDO:equivalentTo", source="EFO:0006858"} +is_a: MONDO:0005070 {source="EFO:0006858", source="MESH:D009375/inferred", source="MONDO:Redundant", source="NCIT:C3709/inferred"} ! neoplasm +intersection_of: MONDO:0005070 {source="NCIT:C3709"} ! neoplasm +intersection_of: disease_arises_from_structure CL:0000066 {source="NCIT:C3709"} ! epithelial cell +relationship: disease_arises_from_structure CL:0000066 ! epithelial cell +property_value: exactMatch http://identifiers.org/mesh/D009375 +property_value: exactMatch http://identifiers.org/snomedct/118285006 +property_value: exactMatch NCIT:C3709 + +[Term] +id: MONDO:0005627 +name: head and neck cancer +def: "A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma." [NCIT:C4013] +synonym: "cancer of craniocervical region" EXACT [MONDO:patterns/cancer] +synonym: "cancer of head and neck" EXACT [NCIT:C4013] +synonym: "cancer of the head and neck" EXACT [NCIT:C4013] +synonym: "craniocervical region cancer" EXACT [MONDO:patterns/location] +synonym: "head and neck cancer" EXACT [NCIT:C4013] +synonym: "head and neck malignant neoplasia" EXACT [MONDO:patterns/cancer] +synonym: "head and neck neoplasm" BROAD [DOID:11934, MTH:NOCODE] +synonym: "head and neck tumours" BROAD [DOID:11934] +synonym: "head/neck neoplasm" BROAD [DOID:11934] +synonym: "malignant craniocervical region neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant head and neck neoplasm" EXACT [NCIT:C4013] +synonym: "malignant head and neck tumor" EXACT [NCIT:C4013] +synonym: "malignant neoplasm of craniocervical region" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of head and neck" EXACT [NCIT:C4013] +synonym: "malignant neoplasm of the head and neck" EXACT [NCIT:C4013] +synonym: "malignant tumor of head and neck" EXACT [NCIT:C4013] +synonym: "malignant tumor of the head and neck" EXACT [NCIT:C4013] +xref: DOID:11934 {source="MONDO:equivalentTo", source="EFO:0006859"} +xref: EFO:0006859 {source="MONDO:equivalentTo"} +xref: NCIT:C4013 {source="MONDO:equivalentTo", source="EFO:0006859"} +xref: UMLS:C0278996 {source="MONDO:equivalentTo", source="NCIT:C4013"} +is_a: MONDO:0004992 {source="DOID:11934", source="DOID:11934/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0005586 {source="EFO:0006859", source="MONDO:Redundant", source="NCIT:C4013"} ! head and neck neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0007811 ! craniocervical region +property_value: exactMatch DOID:11934 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278996 +property_value: exactMatch NCIT:C4013 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005628 +name: male breast carcinoma +def: "A malignant neoplasm involving the male breast." [https://orcid.org/0000-0002-6601-2165] +synonym: "breast cancer in men" RELATED [GARD:0009312] +synonym: "breast cancer, male" RELATED [GARD:0009312] +synonym: "carcinoma of Male breast" EXACT [NCIT:C3862] +synonym: "carcinoma of male breast" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the Male breast" EXACT [NCIT:C3862] +synonym: "Male breast cancer" EXACT [NCIT:C3862] +synonym: "male breast cancer" EXACT [NCIT:C3862] +synonym: "Male breast carcinoma" EXACT [NCIT:C3862] +synonym: "male breast carcinoma" EXACT [MONDO:patterns/location] +synonym: "malignant neoplasm of male breast" EXACT [DOID:1614] +synonym: "neoplasm of male breast" EXACT [DOID:1614] +xref: DOID:1614 {source="EFO:0006861", source="MONDO:equivalentTo"} +xref: EFO:0006861 {source="MONDO:equivalentTo"} +xref: GARD:0009312 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD9:175.9 {source="MONDO:relatedTo", source="MONDO:i2s", source="DOID:1614"} +xref: MESH:D018567 {source="MONDO:equivalentTo", source="DOID:1614"} +xref: NCIT:C3862 {source="EFO:0006861", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:372095001 {source="MONDO:equivalentTo"} +xref: UMLS:C0238033 {source="MONDO:equivalentTo", source="NCIT:C3862"} +xref: UMLS:C0242787 {source="MONDO:equivalentTo"} +xref: UMLS:C0242788 {source="MONDO:equivalentTo", source="DOID:1614"} +is_a: MONDO:0004989 {source="EFO:0006861", source="MONDO:Redundant", source="NCIT:C3862"} ! breast carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0016410 ! male breast +relationship: disease_has_location UBERON:0016410 ! male breast +property_value: exactMatch DOID:1614 +property_value: exactMatch http://identifiers.org/mesh/D018567 +property_value: exactMatch http://identifiers.org/snomedct/372095001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238033 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0242787 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0242788 +property_value: exactMatch NCIT:C3862 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005642 +name: atopic conjunctivitis +def: "Conjunctivitis due to hypersensitivity to various allergens." [MESH:D003233] +synonym: "allergic conjunctivitis" EXACT [MONDO:ambiguous, NCIT:C34506] +synonym: "allergic conjunctivitis (disease)" EXACT [] +synonym: "allergic form of conjunctivitis (disease)" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "Atopic conjunctivitis" EXACT [NCIT:C34506] +xref: DOID:11204 {source="MONDO:equivalentTo", source="EFO:0007141"} +xref: EFO:0007141 {source="MONDO:equivalentTo"} +xref: HP:0007879 {source="MONDO:otherHierarchy"} +xref: ICD9:372.14 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C34506 {source="DOID:11204", source="MONDO:equivalentTo"} +xref: SCTID:473460002 {source="DOID:11204", source="MONDO:equivalentTo"} +xref: UMLS:C0009766 {source="DOID:11204", source="NCIT:C34506", source="MONDO:equivalentTo"} +is_a: MONDO:0002314 {source="DOID:11204"} ! chronic conjunctivitis +is_a: MONDO:0005551 ! eye allergy +intersection_of: MONDO:0003799 ! conjunctivitis +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +property_value: exactMatch DOID:11204 +property_value: exactMatch http://identifiers.org/snomedct/473460002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009766 +property_value: exactMatch NCIT:C34506 + +[Term] +id: MONDO:0005649 +name: appendicitis +def: "Acute inflammation of the vermiform appendix." [NCIT:P378] +synonym: "acute appendicitis" NARROW [DOID:8337] +synonym: "acute appendicitis with generalized peritonitis" NARROW [DOID:8337] +synonym: "acute appendicitis with peritoneal abscess" NARROW [DOID:8337] +synonym: "inflammation of vermiform appendix" EXACT [] +synonym: "vermiform appendix inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:8337 {source="EFO:0007149", source="MONDO:equivalentTo"} +xref: EFO:0007149 {source="MONDO:equivalentTo"} +xref: ICD9:540-543.99 {source="DOID:8337"} +xref: ICD9:541 {source="DOID:8337"} +xref: MESH:D001064 {source="DOID:8337", source="EFO:0007149", source="MONDO:equivalentTo"} +xref: NCIT:C35145 {source="DOID:8337", source="MONDO:equivalentTo"} +xref: SCTID:74400008 {source="DOID:8337", source="MONDO:equivalentTo"} +xref: UMLS:C0003615 {source="DOID:8337", source="MONDO:equivalentTo"} +is_a: MONDO:0002031 {source="DOID:8337", source="MESH:D001064", source="MONDO:Entailed", source="MONDO:Redundant"} ! cecal disorder +is_a: MONDO:0002269 ! gastroenteritis +is_a: MONDO:0056798 ! disorder of appendix +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001154 ! vermiform appendix +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +relationship: disease_has_inflammation_site UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:8337 +property_value: exactMatch http://identifiers.org/mesh/D001064 +property_value: exactMatch http://identifiers.org/snomedct/74400008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003615 +property_value: exactMatch NCIT:C35145 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005694 +name: cecal neoplasm +def: "A benign or malignant neoplasm that affects the cecum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Cecal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." [NCIT:P378] +synonym: "caecum neoplasm" EXACT [] +synonym: "caecum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "caecum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "cecal benign neoplasm" RELATED [DOID:1517] +synonym: "cecum neoplasm" EXACT [DOID:1517, NCIT:C4433] +synonym: "cecum tumor" EXACT [NCIT:C4433] +synonym: "neoplasm of caecum" EXACT [DOID:1517, MONDO:patterns/neoplasm] +synonym: "neoplasm of cecum" EXACT [NCIT:C4433] +synonym: "neoplasm of the cecum" EXACT [NCIT:C4433] +synonym: "tumor of caecum" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of cecum" EXACT [NCIT:C4433] +synonym: "tumor of the cecum" EXACT [NCIT:C4433] +xref: DOID:1517 {source="MONDO:equivalentTo", source="EFO:0007197"} +xref: EFO:0007197 {source="MONDO:equivalentTo"} +xref: MESH:D002430 {source="MONDO:equivalentTo", source="EFO:0007197", source="DOID:1517"} +xref: NCIT:C4433 {source="MONDO:equivalentTo", source="DOID:1517"} +xref: SCTID:126839008 {source="MONDO:equivalentTo", source="DOID:1517"} +xref: UMLS:C0007528 {source="MONDO:equivalentTo", source="NCIT:C4433", source="DOID:1517"} +is_a: MONDO:0002031 {source="MESH:D002430", source="MONDO:Redundant"} ! cecal disorder +is_a: MONDO:0005401 {source="EFO:0007197/inferred", source="MONDO:Redundant", source="NCIT:C4433"} ! colonic neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:1517 +property_value: exactMatch http://identifiers.org/mesh/D002430 +property_value: exactMatch http://identifiers.org/snomedct/126839008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007528 +property_value: exactMatch NCIT:C4433 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005728 +name: diaphragm disorder +def: "A disease involving the diaphragm." [https://orcid.org/0000-0002-6601-2165] +synonym: "diaphragm disease" EXACT [MONDO:patterns/location] +synonym: "diaphragm disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "diaphragmatic disease" RELATED [] +synonym: "diaphragmatic disorder" RELATED [] +synonym: "disease of diaphragm" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of diaphragm" EXACT [] +synonym: "disorder of diaphragm" EXACT [MONDO:patterns/location_top] +xref: DOID:10481 {source="MONDO:equivalentTo"} +xref: EFO:0007233 {source="MONDO:equivalentTo"} +xref: ICD9:519.4 {source="DOID:10481"} +xref: SCTID:48475001 {source="MONDO:equivalentTo", source="DOID:10481"} +xref: UMLS:C0152097 {source="MONDO:equivalentTo", source="DOID:10481"} +is_a: MONDO:0005087 {source="MONDO:Redundant"} ! respiratory system disorder +is_a: MONDO:0020120 ! skeletal muscle disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001103 ! diaphragm +relationship: disease_has_location UBERON:0001103 ! diaphragm +property_value: exactMatch DOID:10481 +property_value: exactMatch http://identifiers.org/snomedct/48475001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152097 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005753 +name: epiglottitis +def: "Inflammation of the epiglottis." [NCIT:P378] +synonym: "acute epiglottitis and supraglottitis" EXACT [DOID:9398] +synonym: "inflammation of mucosa of epiglottis" EXACT [] +synonym: "mucosa of epiglottis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "supraglottitis" EXACT [NCIT:C116007] +xref: DOID:9398 {source="MONDO:equivalentTo", source="EFO:0007261"} +xref: EFO:0007261 {source="MONDO:equivalentTo"} +xref: ICD9:464.3 {source="DOID:9398"} +xref: MESH:D004826 {source="MONDO:equivalentTo", source="EFO:0007261", source="DOID:9398"} +xref: NCIT:C116007 {source="MONDO:equivalentTo", source="DOID:9398"} +xref: SCTID:80384002 {source="MONDO:equivalentTo", source="DOID:9398"} +xref: UMLS:C0014541 {source="MONDO:equivalentTo", source="NCIT:C116007", source="DOID:9398"} +is_a: MONDO:0004867 {source="DOID:9398"} ! upper respiratory tract disorder +is_a: MONDO:0020579 ! mucositis +is_a: MONDO:0020592 ! disorder of pharynx +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0004982 ! mucosa of epiglottis +relationship: disease_has_inflammation_site UBERON:0004982 ! mucosa of epiglottis +property_value: exactMatch DOID:9398 +property_value: exactMatch http://identifiers.org/mesh/D004826 +property_value: exactMatch http://identifiers.org/snomedct/80384002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014541 +property_value: exactMatch NCIT:C116007 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005756 +name: ethmoid sinusitis +def: "An acute or chronic inflammatory process affecting the mucous membrane of the ethmoid sinus." [NCIT:P378] +synonym: "ethmoid bone sinusitis" EXACT [MONDO:patterns/location] +synonym: "ethmoidal sinusitis" EXACT [DOID:9507, NCIT:C34597] +synonym: "ethmoiditis" EXACT [DOID:9507] +synonym: "sinusitis of ethmoid bone" EXACT [MONDO:design_pattern] +xref: DOID:9507 {source="MONDO:equivalentTo", source="EFO:0007264"} +xref: EFO:0007264 {source="MONDO:equivalentTo"} +xref: MESH:D015521 {source="MONDO:equivalentTo", source="DOID:9507", source="EFO:0007264"} +xref: NCIT:C34597 {source="MONDO:equivalentTo", source="DOID:9507"} +xref: SCTID:18643000 {source="MONDO:equivalentTo", source="DOID:9507"} +xref: UMLS:C0015029 {source="MONDO:equivalentTo", source="DOID:9507", source="NCIT:C34597"} +is_a: MONDO:0005961 {source="DOID:9507", source="EFO:0007264", source="MESH:D015521", source="MONDO:Redundant", source="NCIT:C34597"} ! sinusitis +is_a: MONDO:0023369 ! disorder of facial skeleton +intersection_of: MONDO:0005961 ! sinusitis +intersection_of: disease_has_location UBERON:0001679 ! ethmoid bone +relationship: disease_has_location UBERON:0001679 ! ethmoid bone +property_value: exactMatch DOID:9507 +property_value: exactMatch http://identifiers.org/mesh/D015521 +property_value: exactMatch http://identifiers.org/snomedct/18643000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015029 +property_value: exactMatch NCIT:C34597 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0005792 +name: herpes simplex virus gingivostomatitis +def: "Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents." [MESH:D013283] +synonym: "Gingivostomatitides, herpetic" RELATED [MESH:D013283] +synonym: "Gingivostomatitis, herpetic" RELATED [MESH:D013283] +synonym: "Herpes simplex, oral" RELATED [MESH:D013283] +synonym: "herpetic Gingivostomatitides" RELATED [MESH:D013283] +synonym: "herpetic Gingivostomatitis" RELATED [MESH:D013283] +synonym: "herpetic Stomatitides" RELATED [MESH:D013283] +synonym: "herpetic stomatitis" RELATED [MESH:D013283] +synonym: "oral Herpes simplex" RELATED [MESH:D013283] +synonym: "simplex, oral Herpes" RELATED [MESH:D013283] +synonym: "Simplexvirus caused stomatitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Simplexvirus stomatitis" EXACT [] +synonym: "Stomatitides, herpetic" RELATED [MESH:D013283] +xref: EFO:0007307 {source="MONDO:equivalentTo"} +xref: MESH:D013283 {source="MONDO:equivalentTo", source="EFO:0007307"} +xref: SCTID:57920007 {source="MONDO:equivalentTo"} +is_a: MONDO:0004609 {source="EFO:0007307", source="MESH:D013283", source="MONDO:Redundant"} ! herpes simplex infectious disease +is_a: MONDO:0004842 {source="MESH:D013283", source="MONDO:Redundant"} ! stomatitis +intersection_of: MONDO:0004842 ! stomatitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +property_value: exactMatch http://identifiers.org/mesh/D013283 +property_value: exactMatch http://identifiers.org/snomedct/57920007 + +[Term] +id: MONDO:0005794 +name: Herpesviridae infectious disease +def: "Virus diseases caused by the herpesviridae." [MESH:D006566] +synonym: "herpes infection" RELATED [] +synonym: "Herpesviridae caused disease or disorder" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Herpesviridae disease or disorder" EXACT [] +synonym: "Herpesviridae infection" RELATED [MESH:D006566] +synonym: "Herpesviridae infections" EXACT [MONDO:0024460] +synonym: "Herpesvirus infection" RELATED [MESH:D006566] +synonym: "herpesvirus infection" EXACT [] +synonym: "Herpesvirus infections" RELATED [MESH:D006566] +synonym: "infection, Herpesviridae" RELATED [MESH:D006566] +synonym: "infection, Herpesvirus" RELATED [MESH:D006566] +synonym: "infections, Herpesviridae" RELATED [MESH:D006566] +synonym: "infections, Herpesvirus" RELATED [MESH:D006566] +xref: EFO:0007309 {source="MONDO:equivalentTo"} +xref: MESH:D006566 {source="MONDO:equivalentTo", source="EFO:0007309"} +xref: SCTID:23513009 {source="MONDO:equivalentTo"} +is_a: MONDO:0100329 ! primary viral infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10292 ! disease has primary infectious agent Herpesviridae +relationship: MONDO:0100332 NCBITaxon:10292 ! disease has primary infectious agent Herpesviridae +property_value: exactMatch http://identifiers.org/mesh/D006566 +property_value: exactMatch http://identifiers.org/snomedct/23513009 + +[Term] +id: MONDO:0005800 +name: hordeolum +def: "An acute, localized swelling of the eyelid that may be external or internal and usually is a pyogenic (typically staphylococcal) infection or abscess." [https://www.merckmanuals.com/professional/eye-disorders/eyelid-and-lacrimal-disorders/chalazion-and-hordeolum-stye] +synonym: "blepharitis of eyelid gland" EXACT [MONDO:design_pattern] +synonym: "boil of eyelid" EXACT [DOID:9909] +synonym: "eyelid gland blepharitis" EXACT [MONDO:patterns/location] +synonym: "furuncle of eyelid" EXACT [DOID:9909] +synonym: "Stye" EXACT [DOID:9909, NCIT:C118722] +xref: DOID:9909 {source="EFO:0007315", source="MONDO:equivalentTo"} +xref: EFO:0007315 {source="MONDO:equivalentTo"} +xref: MESH:D006726 {source="EFO:0007315", source="MONDO:equivalentTo", source="DOID:9909"} +xref: NCIT:C118722 {source="MONDO:equivalentTo", source="DOID:9909"} +xref: SCTID:397513003 {source="MONDO:equivalentTo", source="DOID:9909"} +xref: UMLS:C0019917 {source="MONDO:equivalentTo", source="NCIT:C118722", source="DOID:9909"} +is_a: MONDO:0004785 ! blepharitis +is_a: MONDO:0005545 ! staphylococcus aureus infection +is_a: MONDO:0024295 ! skin disease caused by bacterial infection +is_a: MONDO:0043885 ! eye infectious disorder +intersection_of: MONDO:0004785 ! blepharitis +intersection_of: disease_has_location UBERON:0013229 ! eyelid gland +relationship: disease_has_feature HP:0010606 ! Hordeolum +relationship: disease_has_feature MONDO:0004785 ! blepharitis +relationship: disease_has_location UBERON:0013229 ! eyelid gland +property_value: exactMatch DOID:9909 +property_value: exactMatch http://identifiers.org/mesh/D006726 +property_value: exactMatch http://identifiers.org/snomedct/397513003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019917 +property_value: exactMatch NCIT:C118722 + +[Term] +id: MONDO:0005806 +name: hypopharynx cancer +def: "A primary or metastatic malignant neoplasm that affects the hypopharynx." [NCIT:P378] +synonym: "hypopharyngeal cancer" EXACT [DOID:8533, MTH:NOCODE] +synonym: "hypopharynx pharynx cancer" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "hypural pharynx cancer" EXACT [MONDO:patterns/location] +synonym: "malignant hypopharyngeal neoplasm" EXACT [NCIT:C7190] +synonym: "malignant hypopharyngeal tumor" EXACT [DOID:8533, NCIT:C7190] +synonym: "malignant neoplasm of hypopharynx" EXACT [DOID:8533, ICD9CM:148, NCIT:C7190] +synonym: "malignant neoplasm of ill-defined sites within the lip and oral cavity" EXACT [DOID:8533] +synonym: "malignant neoplasm of other specified hypopharyngeal site" EXACT [DOID:8533] +synonym: "malignant neoplasm of other specified sites of hypopharynx" EXACT [DOID:8533] +synonym: "malignant neoplasm of posterior hypopharyngeal wall" EXACT [DOID:8533] +synonym: "malignant neoplasm of posterior wall of hypopharynx" EXACT [DOID:8533, MTH:U001377] +synonym: "malignant neoplasm of the hypopharynx" EXACT [NCIT:C7190] +synonym: "malignant tumor of hypopharynx" EXACT [NCIT:C7190] +synonym: "malignant tumor of posterior wall of hypopharynx" EXACT [DOID:8533] +synonym: "malignant tumor of the hypopharynx" EXACT [NCIT:C7190] +synonym: "malignant tumour of hypopharynx" EXACT [DOID:8533] +synonym: "pharynx cancer of hypopharynx" EXACT [MONDO:design_pattern] +xref: DOID:8533 {source="MONDO:equivalentTo", source="EFO:0007321"} +xref: EFO:0007321 {source="MONDO:equivalentTo"} +xref: GARD:0009334 {source="MONDO:equivalentTo"} +xref: ICD10CM:C13 {source="DOID:8533", source="MONDO:equivalentTo"} +xref: ICD9:148 {source="DOID:8533"} +xref: ICD9:148.3 {source="DOID:8533", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:148.9 {source="DOID:8533"} +xref: MESH:D007012 {source="DOID:8533", source="MONDO:equivalentTo", source="EFO:0007321"} +xref: NCIT:C7190 {source="DOID:8533", source="MONDO:equivalentTo"} +xref: SCTID:303012000 {source="DOID:8533", source="MONDO:equivalentTo"} +is_a: MONDO:0005517 {source="DOID:8533", source="EFO:0007321", source="MESH:D007012", source="MONDO:Redundant", source="NCIT:C7190"} ! pharynx cancer +is_a: MONDO:0021358 ! neoplasm of hypopharynx +intersection_of: MONDO:0005517 ! pharynx cancer +intersection_of: disease_has_location UBERON:0001051 ! hypopharynx +property_value: exactMatch DOID:8533 +property_value: exactMatch http://identifiers.org/mesh/D007012 +property_value: exactMatch http://identifiers.org/snomedct/303012000 +property_value: exactMatch https://icd.codes/icd10cm/C13 +property_value: exactMatch NCIT:C7190 + +[Term] +id: MONDO:0005814 +name: intestinal cancer +def: "A malignant neoplasm involving the intestine" [https://orcid.org/0000-0002-6601-2165] +synonym: "bowel cancer" EXACT [NCIT:C4572] +synonym: "cancer of intestine" EXACT [MONDO:patterns/cancer, NCIT:C4572] +synonym: "cancer of the intestine" EXACT [NCIT:C4572] +synonym: "intestinal cancer" EXACT [NCIT:C4572] +synonym: "intestinal neoplasms, malignant" EXACT [NCIT:C4572] +synonym: "intestinal tumors, malignant" EXACT [NCIT:C4572] +synonym: "intestine cancer" EXACT [MONDO:patterns/location] +synonym: "malignant intestinal neoplasm" EXACT [NCIT:C4572] +synonym: "malignant intestinal neoplasms" EXACT [NCIT:C4572] +synonym: "malignant intestinal tumor" EXACT [NCIT:C4572] +synonym: "malignant intestinal tumors" EXACT [DOID:10155, NCIT:C4572] +synonym: "malignant intestine neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4572] +synonym: "malignant intestine tumor" EXACT [NCIT:C4572] +synonym: "malignant neoplasm of intestine" EXACT [DOID:10155, MONDO:patterns/cancer, NCIT:C4572] +synonym: "malignant neoplasm of the intestine" EXACT [NCIT:C4572] +synonym: "malignant tumor of intestine" EXACT [NCIT:C4572] +synonym: "malignant tumor of the intestine" EXACT [NCIT:C4572] +xref: DOID:10155 {source="MONDO:equivalentTo", source="EFO:0007330"} +xref: EFO:0007330 {source="MONDO:equivalentTo"} +xref: ICD9:159.0 {source="DOID:10155"} +xref: MESH:D007414 {source="MONDO:equivalentTo", source="DOID:10155", source="EFO:0007330"} +xref: NCIT:C4572 {source="MONDO:equivalentTo", source="DOID:10155"} +xref: SCTID:363508008 {source="MONDO:equivalentTo", source="DOID:10155"} +xref: UMLS:C0346627 {source="NCIT:C4572", source="MONDO:equivalentTo", source="DOID:10155"} +is_a: MONDO:0002516 {source="DOID:10155", source="MONDO:Redundant", source="NCIT:C4572"} ! digestive system cancer +is_a: MONDO:0021118 {source="MONDO:Redundant", source="NCIT:C4572"} ! intestinal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000160 ! intestine +property_value: exactMatch DOID:10155 +property_value: exactMatch http://identifiers.org/mesh/D007414 +property_value: exactMatch http://identifiers.org/snomedct/363508008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346627 +property_value: exactMatch NCIT:C4572 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005815 +name: pancreatic neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade)." [NCIT:C27031] +comment: Editor note: classified as carcinoma in EFO +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "endocrine pancreas cancer" NARROW [DOID:1799] +synonym: "endocrine pancreas neoplasm" EXACT [] +synonym: "endocrine pancreas neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "endocrine pancreas tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "islet cell neoplasm" NARROW [DOID:1799] +synonym: "islet cell tumor" NARROW [DOID:1799] +synonym: "Islet cell tumors" NARROW [GARD:0007311] +synonym: "islet cell tumour" NARROW [DOID:1799] +synonym: "Islet of Langerhans tumor" RELATED [GARD:0007311] +synonym: "malignant pancreatic endocrine tumor" NARROW [DOID:1799, NCIT:C3770] +synonym: "malignant tumor of endocrine pancreas" EXACT [DOID:1799] +synonym: "neoplasm of endocrine pancreas" EXACT [MONDO:patterns/neoplasm] +synonym: "neuroendocrine neoplasm of pancreas" RELATED [Orphanet:506052] +synonym: "pancreatic endocrine neoplasm" EXACT [DOID:1799, NCIT:C27031] +synonym: "pancreatic NEN" EXACT [Orphanet:506052] +synonym: "pancreatic neuroendocrine neoplasm" EXACT [NCIT:C27031, Orphanet:506052] +synonym: "PNEN" EXACT ABBREVIATION [Orphanet:506052] +synonym: "tumor of endocrine pancreas" EXACT [MONDO:patterns/neoplasm] +xref: DOID:1799 {source="MONDO:equivalentTo", source="EFO:0007331"} +xref: EFO:0007331 {source="MONDO:equivalentTo"} +xref: GARD:0007311 {source="MONDO:equivalentTo"} +xref: ICDO:8150/1 {source="NCIT:C27031"} +xref: NCIT:C27031 {source="MONDO:equivalentTo", source="DOID:1799"} +xref: Orphanet:506052 {source="MONDO:equivalentTo"} +xref: SCTID:254611009 {source="MONDO:equivalentTo", source="DOID:1799"} +is_a: MONDO:0001933 {source="DOID:1799", source="MONDO:Redundant", source="NCIT:C27031"} ! endocrine pancreas disorder +is_a: MONDO:0021040 {source="EFO:0007331", source="MONDO:0018520-obsoleted", source="MONDO:Entailed", source="NCIT:C27031"} ! pancreatic neoplasm +is_a: MONDO:0024503 {source="Orphanet:506052"} ! digestive system neuroendocrine neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000016 ! endocrine pancreas +property_value: exactMatch DOID:1799 +property_value: exactMatch http://identifiers.org/snomedct/254611009 +property_value: exactMatch NCIT:C27031 +property_value: exactMatch Orphanet:506052 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005832 +name: lymphangitis +def: "Inflammation of the lymphatic vessels." [NCIT:P378] +synonym: "inflammation of lymphatic vessel" EXACT [] +synonym: "lymphatic vessel inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:9317 {source="MONDO:equivalentTo", source="EFO:0007351"} +xref: EFO:0007351 {source="MONDO:equivalentTo"} +xref: ICD10CM:I89.1 {source="DOID:9317", source="MONDO:equivalentTo"} +xref: ICD9:457.2 {source="DOID:9317", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D008205 {source="DOID:9317", source="MONDO:equivalentTo", source="EFO:0007351"} +xref: NCIT:C34790 {source="DOID:9317", source="MONDO:equivalentTo"} +xref: SCTID:1415005 {source="DOID:9317", source="MONDO:equivalentTo"} +xref: UMLS:C0024225 {source="DOID:9317", source="NCIT:C34790", source="MONDO:equivalentTo"} +is_a: MONDO:0005833 {source="DOID:9317", source="MESH:D008205", source="MONDO:Redundant"} ! lymphatic system disorder +is_a: MONDO:0018882 ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001473 ! lymphatic vessel +relationship: disease_has_inflammation_site UBERON:0001473 ! lymphatic vessel +property_value: exactMatch DOID:9317 +property_value: exactMatch http://identifiers.org/mesh/D008205 +property_value: exactMatch http://identifiers.org/snomedct/1415005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024225 +property_value: exactMatch https://icd.codes/icd10cm/I89.1 +property_value: exactMatch NCIT:C34790 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005833 +name: lymphatic system disorder +def: "A disease involving the lymphatic part of lymphoid system." [https://orcid.org/0000-0002-6601-2165] +comment: Editor note: check alignment to anatomy, consider lymphoid system disease +synonym: "adenopathy" RELATED [DOID:75] +synonym: "disease of lymphatic part of lymphoid system" EXACT [MONDO:patterns/location_top] +synonym: "disease of lympoid system" RELATED [DOID:75] +synonym: "disease or disorder of lymphatic part of lymphoid system" EXACT [] +synonym: "disorder of lymph node and lymphatics" EXACT [DOID:75] +synonym: "disorder of lymphatic part of lymphoid system" EXACT [MONDO:patterns/location_top] +synonym: "disorder of lymphatic system" EXACT [DOID:75] +synonym: "disorder of lymphoid system" RELATED [DOID:75] +synonym: "glands, swollen" EXACT [NCIT:C50764] +synonym: "lymphadenopathy" NARROW [NCIT:C50764] +synonym: "lymphangiopathy" NARROW [DOID:75] +synonym: "lymphatic disease" EXACT [DOID:75, MTH:461, MTH:NOCODE] +synonym: "lymphatic disorder" EXACT [DOID:75, NCIT:C3206] +synonym: "lymphatic part of lymphoid system disease" EXACT [MONDO:patterns/location] +synonym: "lymphatic part of lymphoid system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lympoid system disease" RELATED [DOID:75] +synonym: "swollen gland" EXACT [NCIT:C50764] +synonym: "swollen glands" EXACT [NCIT:C50764] +xref: DOID:75 {source="MONDO:equivalentTo"} +xref: EFO:0007352 {source="MONDO:equivalentTo"} +xref: MESH:D008206 {source="DOID:75", source="MONDO:equivalentTo"} +xref: NCIT:C50764 {source="MONDO:equivalentTo"} +xref: SCTID:362971004 {source="DOID:75", source="MONDO:equivalentTo"} +xref: UMLS:C0024228 {source="DOID:75", source="MONDO:equivalentTo"} +is_a: MONDO:0044986 ! lymphoid system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0006558 ! lymphatic part of lymphoid system +relationship: disease_has_location UBERON:0006558 ! lymphatic part of lymphoid system +property_value: exactMatch DOID:75 +property_value: exactMatch http://identifiers.org/mesh/D008206 +property_value: exactMatch http://identifiers.org/snomedct/362971004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024228 +property_value: exactMatch NCIT:C50764 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005836 +name: male reproductive organ cancer +def: "A primary or metastatic malignant neoplasm involving the male reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, and testicular embryonal carcinoma." [NCIT:C8561] +synonym: "cancer of male reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "male genital cancer" EXACT [DOID:3856] +synonym: "male genital neoplasm" BROAD [DOID:3856] +synonym: "male reproductive organ cancer" EXACT [MONDO:patterns/location] +synonym: "male reproductive system neoplasm" BROAD [DOID:3856] +synonym: "malignant male reproductive organ neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant Male reproductive system neoplasm" EXACT [NCIT:C8561] +synonym: "malignant Male reproductive system tumor" EXACT [NCIT:C8561] +synonym: "malignant neoplasm of male genital organ" EXACT [DOID:3856] +synonym: "malignant neoplasm of male genital organ or tract" EXACT [DOID:3856] +synonym: "malignant neoplasm of male genital organ, site unspecified" EXACT [DOID:3856, ICD9CM:187.9] +synonym: "malignant neoplasm of male genital organs" EXACT [DOID:3856] +synonym: "malignant neoplasm of male reproductive organ" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of Male reproductive system" EXACT [NCIT:C8561] +synonym: "malignant neoplasm of the Male reproductive system" EXACT [NCIT:C8561] +synonym: "malignant tumor of male genital organ" EXACT [DOID:3856, MTH:U001031] +synonym: "malignant tumor of Male reproductive system" EXACT [NCIT:C8561] +synonym: "malignant tumor of male reproductive system" EXACT [DOID:3856, NCIT:C8561] +synonym: "malignant tumor of the Male reproductive system" EXACT [NCIT:C8561] +synonym: "neoplasm of male genital organ" BROAD [DOID:3856] +synonym: "tumor of male reproductive system" BROAD [DOID:3856, NCIT:C3054] +xref: DOID:3856 {source="MONDO:equivalentTo", source="EFO:0007355"} +xref: EFO:0007355 {source="MONDO:equivalentTo"} +xref: ICD9:187.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:187.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:3856"} +xref: MESH:D005834 {source="MONDO:equivalentTo", source="DOID:3856", source="EFO:0007355"} +xref: NCIT:C8561 {source="MONDO:equivalentTo", source="DOID:3856"} +xref: SCTID:363515000 {source="MONDO:equivalentTo", source="DOID:3856"} +is_a: MONDO:0002149 {source="DOID:3856", source="MONDO:Redundant", source="NCIT:C8561"} ! reproductive system cancer +is_a: MONDO:0024582 {source="MONDO:Redundant", source="NCIT:C8561"} ! male reproductive system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003135 ! male reproductive organ +property_value: exactMatch DOID:3856 +property_value: exactMatch http://identifiers.org/mesh/D005834 +property_value: exactMatch http://identifiers.org/snomedct/363515000 +property_value: exactMatch NCIT:C8561 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005837 +name: mandibular cancer +def: "A malignant neoplasm involving the mandible" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of mandible" EXACT [MONDO:patterns/cancer] +synonym: "malignant mandible neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of inferior maxilla" EXACT [DOID:2338] +synonym: "malignant neoplasm of lower jaw bone" EXACT [DOID:2338, NCIT:C35178] +synonym: "malignant neoplasm of mandible" EXACT [DOID:2338, MONDO:patterns/cancer] +synonym: "mandible cancer" EXACT [DOID:2338, MONDO:patterns/location] +synonym: "mandibular neoplasm" BROAD [DOID:2338] +synonym: "neoplasm of mandible" BROAD [DOID:2338] +xref: DOID:2338 {source="EFO:0007356", source="MONDO:equivalentTo"} +xref: EFO:0007356 {source="MONDO:equivalentTo"} +xref: ICD9:170.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2338"} +xref: MESH:D008339 {source="EFO:0007356", source="MONDO:equivalentTo", source="DOID:2338"} +xref: NCIT:C35178 {source="MONDO:equivalentTo", source="DOID:2338"} +xref: SCTID:448668007 {source="MONDO:equivalentTo", source="DOID:2338"} +is_a: MONDO:0002131 {source="DOID:2338", source="MESH:D008339", source="MONDO:Entailed", source="MONDO:Redundant"} ! jaw cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001684 ! mandible +relationship: disease_has_location UBERON:0001684 ! mandible +property_value: exactMatch DOID:2338 +property_value: exactMatch http://identifiers.org/mesh/D008339 +property_value: exactMatch http://identifiers.org/snomedct/448668007 +property_value: exactMatch NCIT:C35178 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005841 +name: maxillary neoplasm +def: "Cancer or tumors of the maxilla or upper jaw." [MESH:D008441] +synonym: "bone of upper jaw neoplasm" EXACT [] +synonym: "bone of upper jaw neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "bone of upper jaw tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "maxillary cancer" RELATED [DOID:4618] +synonym: "maxillary neoplasm" EXACT [DOID:4618] +synonym: "neoplasm of bone of upper jaw" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of bone of upper jaw" EXACT [MONDO:patterns/neoplasm] +synonym: "upper jaw bone cancer" RELATED [DOID:4618] +xref: DOID:4618 {source="MONDO:equivalentTo", source="EFO:0007360"} +xref: EFO:0007360 {source="MONDO:equivalentTo"} +xref: MESH:D008441 {source="MONDO:equivalentTo", source="EFO:0007360", source="DOID:4618"} +xref: SCTID:126550004 {source="MONDO:equivalentTo", source="DOID:4618"} +xref: UMLS:C0024954 {source="MONDO:equivalentTo", source="DOID:4618"} +is_a: MONDO:0021580 ! neoplasm of jaw +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0011597 ! bone of upper jaw +relationship: disease_has_location UBERON:0011597 ! bone of upper jaw +property_value: exactMatch DOID:4618 +property_value: exactMatch http://identifiers.org/mesh/D008441 +property_value: exactMatch http://identifiers.org/snomedct/126550004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024954 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0005842 +name: maxillary sinusitis +def: "An acute or chronic inflammatory process affecting the mucous membrane of the maxillary sinus." [NCIT:P378] +xref: DOID:2051 {source="MONDO:equivalentTo", source="EFO:0007361"} +xref: EFO:0007361 {source="MONDO:equivalentTo"} +xref: MESH:D015523 {source="MONDO:equivalentTo", source="EFO:0007361", source="DOID:2051"} +xref: NCIT:C34809 {source="MONDO:equivalentTo", source="DOID:2051"} +xref: SCTID:88348008 {source="MONDO:equivalentTo", source="DOID:2051"} +xref: UMLS:C0024959 {source="MONDO:equivalentTo", source="NCIT:C34809", source="DOID:2051"} +is_a: MONDO:0005961 {source="DOID:2051", source="EFO:0007361", source="MESH:D015523", source="MONDO:Redundant", source="NCIT:C34809"} ! sinusitis +is_a: MONDO:0006858 ! mouth disorder +is_a: MONDO:0023369 ! disorder of facial skeleton +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001764 ! maxillary sinus +relationship: disease_has_inflammation_site UBERON:0001764 ! maxillary sinus +property_value: exactMatch DOID:2051 +property_value: exactMatch http://identifiers.org/mesh/D015523 +property_value: exactMatch http://identifiers.org/snomedct/88348008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024959 +property_value: exactMatch NCIT:C34809 + +[Term] +id: MONDO:0005843 +name: mediastinal cancer +def: "A malignant neoplasm involving the mediastinum" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of mediastinum" EXACT [MONDO:patterns/cancer, NCIT:C3549] +synonym: "cancer of the mediastinum" EXACT [NCIT:C3549] +synonym: "malignant mediastinal neoplasm" EXACT [NCIT:C3549] +synonym: "malignant mediastinal tumor" EXACT [NCIT:C3549] +synonym: "malignant mediastinum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of mediastinum" EXACT [MONDO:patterns/cancer, NCIT:C3549] +synonym: "malignant neoplasm of the mediastinum" EXACT [NCIT:C3549] +synonym: "malignant tumor of mediastinum" EXACT [NCIT:C3549] +synonym: "malignant tumor of the mediastinum" EXACT [NCIT:C3549] +synonym: "mediastinal cancer" EXACT [NCIT:C3549] +synonym: "mediastinal tumor" BROAD [DOID:5559, NCIT:C3221] +synonym: "mediastinum cancer" EXACT [DOID:5559, MONDO:patterns/location] +synonym: "tumour of mediastinum" BROAD [DOID:5559] +xref: DOID:5559 {source="MONDO:equivalentTo", source="EFO:0007362"} +xref: EFO:0007362 {source="MONDO:equivalentTo"} +xref: ICD9:164.9 {source="DOID:5559", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D008479 {source="DOID:5559", source="MONDO:equivalentTo", source="EFO:0007362"} +xref: NCIT:C3549 {source="DOID:5559", source="MONDO:equivalentTo"} +xref: SCTID:363494000 {source="DOID:5559", source="MONDO:equivalentTo"} +is_a: MONDO:0003274 {source="DOID:5559", source="MONDO:Redundant", source="NCIT:C3549"} ! thoracic cancer +is_a: MONDO:0021386 {source="MONDO:Redundant", source="NCIT:C3549"} ! neoplasm of mediastinum +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch DOID:5559 +property_value: exactMatch http://identifiers.org/mesh/D008479 +property_value: exactMatch http://identifiers.org/snomedct/363494000 +property_value: exactMatch NCIT:C3549 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005845 +name: meningoencephalitis +def: "Inflammation of the meninges and brain, generally secondary to an infectious cause. Pathogens may be bacterial, viral, fungal, or protozoan." [NCIT:P378] +xref: DOID:10554 {source="MONDO:equivalentTo", source="EFO:0007364"} +xref: EFO:0007364 {source="MONDO:equivalentTo"} +xref: MESH:D008590 {source="DOID:10554", source="MONDO:equivalentTo", source="EFO:0007364"} +xref: NCIT:C34813 {source="DOID:10554", source="MONDO:equivalentTo"} +xref: SCTID:7125002 {source="DOID:10554", source="MONDO:equivalentTo"} +xref: UMLS:C0025309 {source="DOID:10554", source="MONDO:equivalentTo", source="NCIT:C34813"} +is_a: MONDO:0019956 {source="MESH:D008590", source="MONDO:Entailed"} ! encephalitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000955 ! brain +intersection_of: disease_has_inflammation_site UBERON:0010743 ! meningeal cluster +relationship: disease_has_inflammation_site UBERON:0010743 ! meningeal cluster +property_value: exactMatch DOID:10554 +property_value: exactMatch http://identifiers.org/mesh/D008590 +property_value: exactMatch http://identifiers.org/snomedct/7125002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025309 +property_value: exactMatch NCIT:C34813 + +[Term] +id: MONDO:0005864 +name: muscle cancer +def: "A malignant neoplasm affecting the skeletal or smooth muscles. Malignant neoplasms arising from the skeletal muscles are called rhabdomyosarcomas. Malignant neoplasms arising from the smooth muscles are called leiomyosarcomas." [NCIT:P378] +synonym: "cancer of muscle structure" EXACT [MONDO:patterns/cancer] +synonym: "malignant muscle neoplasm" EXACT [NCIT:C4883] +synonym: "malignant muscle structure neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant muscle tumor" EXACT [NCIT:C4883] +synonym: "malignant neoplasm of muscle" EXACT [DOID:4045, NCIT:C4883] +synonym: "malignant neoplasm of muscle structure" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the muscle" EXACT [NCIT:C4883] +synonym: "malignant tumor of muscle" EXACT [DOID:4045, NCIT:C4883] +synonym: "malignant tumor of the muscle" EXACT [DOID:4045, NCIT:C4883] +synonym: "muscle structure cancer" EXACT [MONDO:patterns/location] +synonym: "myosarcoma" EXACT [DOID:4045, NCIT:C4883] +xref: DOID:4045 {source="MONDO:equivalentTo", source="EFO:0007384"} +xref: EFO:0007384 {source="MONDO:equivalentTo"} +xref: ICD9:171.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8895/3 {source="NCIT:C4883"} +xref: NCIT:C4883 {source="DOID:4045", source="MONDO:equivalentTo"} +xref: SCTID:363495004 {source="DOID:4045", source="MONDO:equivalentTo"} +xref: UMLS:C0027095 {source="DOID:4045", source="MONDO:equivalentTo"} +xref: UMLS:C0684743 {source="DOID:4045", source="MONDO:equivalentTo", source="NCIT:C4883"} +is_a: MONDO:0000637 {source="DOID:4045"} ! musculoskeletal system cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0005090 ! muscle structure +relationship: disease_has_location UBERON:0005090 ! muscle structure +property_value: exactMatch DOID:4045 +property_value: exactMatch http://identifiers.org/snomedct/363495004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027095 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684743 +property_value: exactMatch NCIT:C4883 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005872 +name: nervous system cancer +def: "A primary or metastatic malignant neoplasm involving the nervous system." [NCIT:C4788] +synonym: "cancer of nervous system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of nervous system" EXACT [DOID:3093, MONDO:patterns/cancer, NCIT:C4788] +synonym: "malignant neoplasm of the nervous system" EXACT [NCIT:C4788] +synonym: "malignant nervous system neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4788] +synonym: "malignant nervous system tumor" EXACT [NCIT:C4788] +synonym: "malignant tumor of nervous system" EXACT [NCIT:C4788] +synonym: "malignant tumor of the nervous system" EXACT [NCIT:C4788] +synonym: "nervous system cancer" EXACT [MONDO:patterns/location] +synonym: "nervous system neoplasm" BROAD [DOID:3093] +synonym: "nervous system neoplasms, malignant" EXACT [NCIT:C4788] +synonym: "neural neoplasm" BROAD [DOID:3093] +synonym: "neural tumor" BROAD [DOID:3093] +synonym: "tumor of the nervous system" BROAD [DOID:3093, NCIT:C3268] +xref: DOID:3093 {source="MONDO:equivalentTo", source="EFO:0007392"} +xref: EFO:0007392 {source="MONDO:equivalentTo"} +xref: ICD9:192 {source="DOID:3093"} +xref: ICD9:192.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:192.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:3093"} +xref: MESH:D009423 {source="MONDO:equivalentTo"} +xref: NCIT:C4788 {source="MONDO:equivalentTo"} +xref: SCTID:372063002 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:3093", source="DOID:3093/inferred", source="EFO:0007392/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0021248 {source="MONDO:Redundant", source="NCIT:C4788"} ! nervous system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001016 ! nervous system +property_value: exactMatch DOID:3093 +property_value: exactMatch http://identifiers.org/mesh/D009423 +property_value: exactMatch http://identifiers.org/snomedct/372063002 +property_value: exactMatch NCIT:C4788 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005885 +name: optic neuritis +def: "Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated." [https://rarediseases.info.nih.gov/diseases/7320/optic-neuritis] +subset: gard_rare {source="GARD:0007320"} +xref: DOID:1210 {source="EFO:0007405", source="MONDO:equivalentTo"} +xref: EFO:0007405 {source="MONDO:equivalentTo"} +xref: GARD:0007320 {source="MONDO:equivalentTo"} +xref: ICD10CM:H46 {source="DOID:1210", source="MONDO:equivalentTo"} +xref: ICD9:377.3 {source="DOID:1210"} +xref: ICD9:377.30 {source="DOID:1210", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:377.39 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009902 {source="DOID:1210", source="EFO:0007405", source="MONDO:equivalentTo"} +xref: NCIT:C84950 {source="DOID:1210", source="MONDO:equivalentTo"} +xref: SCTID:66760008 {source="DOID:1210", source="MONDO:equivalentTo"} +is_a: MONDO:0002135 {source="DOID:1210", source="MESH:D009902", source="MONDO:Redundant", source="NCIT:C84950/inferred"} ! optic nerve disorder +is_a: MONDO:0005156 ! encephalomyelitis +is_a: MONDO:0005328 {source="EFO:0007405", source="MESH:D009902/inferred"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000941 ! cranial nerve II +relationship: disease_has_feature HP:0000572 ! Visual loss +relationship: disease_has_inflammation_site UBERON:0000941 ! cranial nerve II +property_value: exactMatch DOID:1210 +property_value: exactMatch http://identifiers.org/mesh/D009902 +property_value: exactMatch http://identifiers.org/snomedct/66760008 +property_value: exactMatch https://icd.codes/icd10cm/H46 +property_value: exactMatch NCIT:C84950 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7320/optic-neuritis xsd:anyURI {source="GARD:0007320"} + +[Term] +id: MONDO:0005893 +name: pancreatic endocrine carcinoma +def: "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma." [NCIT:C3770] +subset: ordo_disease +synonym: "carcinoma of endocrine pancreas" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, islet cell, malignant" EXACT [NCIT:C3770] +synonym: "endocrine pancreas carcinoma" EXACT [MONDO:patterns/location] +synonym: "high grade pancreatic neuroendocrine carcinoma" EXACT [NCIT:C3770] +synonym: "high-grade pancreatic neuroendocrine carcinoma" EXACT [NCIT:C3770] +synonym: "islet cell cancer" EXACT [NCIT:C3770] +synonym: "islet cell carcinoma" EXACT [NCIT:C3770] +synonym: "islet cell carcinoma (morphologic abnormality)" EXACT [DOID:1798] +synonym: "malignant islet cell tumor" EXACT [NCIT:C3770] +synonym: "malignant neoplasm of islets of Langerhans" EXACT [DOID:1798] +synonym: "malignant pancreatic endocrine tumor" EXACT [NCIT:C3770] +synonym: "neuroendocrine carcinoma of pancreas" RELATED [Orphanet:506098] +synonym: "pancreatic endocrine cancer" EXACT [NCIT:C3770] +synonym: "pancreatic endocrine carcinoma" EXACT [NCIT:C3770] +synonym: "pancreatic NEC" EXACT [NCIT:C3770, Orphanet:506098] +synonym: "pancreatic NEC G3" EXACT [NCIT:C3770] +synonym: "Pancreatic Neuroendocrine cancer" EXACT [NCIT:C3770] +synonym: "pancreatic neuroendocrine carcinoma" EXACT [DOID:1798, NCIT:C3770, Orphanet:506098] +synonym: "poorly differentiated pancreatic endocrine carcinoma" EXACT [NCIT:C3770] +synonym: "poorly-differentiated NEN of pancreas" EXACT [Orphanet:506098] +synonym: "poorly-differentiated neuroendocrine neoplasm of pancreas" EXACT [Orphanet:506098] +synonym: "poorly-differentiated pancreatic NEN" EXACT [Orphanet:506098] +synonym: "poorly-differentiated pancreatic neuroendocrine neoplasm" EXACT [Orphanet:506098] +xref: DOID:1798 {source="EFO:0007416", source="MONDO:equivalentTo"} +xref: EFO:0007416 {source="MONDO:equivalentTo"} +xref: ICD10CM:C25.4 {source="MONDO:equivalentTo", source="DOID:1798"} +xref: ICD9:157.4 {source="DOID:1798"} +xref: ICDO:8150/3 {source="NCIT:C3770"} +xref: MESH:D018273 {source="EFO:0007416", source="MONDO:equivalentTo", source="DOID:1798"} +xref: NCIT:C3770 {source="MONDO:equivalentTo", source="DOID:1798"} +xref: Orphanet:506098 {source="MONDO:equivalentTo"} +xref: SCTID:254612002 {source="MONDO:equivalentTo", source="DOID:1798"} +xref: UMLS:C1328479 {source="NCIT:C3770", source="MONDO:equivalentTo", source="DOID:1798"} +is_a: MONDO:0002120 ! neuroendocrine carcinoma +is_a: MONDO:0005815 {source="DOID:1798", source="MONDO:Redundant", source="NCIT:C3770", source="Orphanet:506098"} ! pancreatic neuroendocrine neoplasm +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C3770/inferred"} ! digestive system carcinoma +is_a: MONDO:0009831 {source="DOID:1798/inferred", source="MONDO:Redundant", source="NCIT:C3770"} ! malignant pancreatic neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000016 ! endocrine pancreas +property_value: exactMatch DOID:1798 +property_value: exactMatch http://identifiers.org/mesh/D018273 +property_value: exactMatch http://identifiers.org/snomedct/254612002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1328479 +property_value: exactMatch https://icd.codes/icd10cm/C25.4 +property_value: exactMatch NCIT:C3770 +property_value: exactMatch Orphanet:506098 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0005899 +name: parotid disorder +def: "A disease involving the parotid gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of parotid gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of parotid gland" EXACT [] +synonym: "disorder of parotid gland" EXACT [MONDO:patterns/location_top] +synonym: "parotid gland disease" EXACT [MONDO:patterns/location] +synonym: "parotid gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:10302 {source="MONDO:equivalentTo"} +xref: EFO:0007422 {source="MONDO:equivalentTo"} +xref: MESH:D010305 {source="DOID:10302", source="MONDO:equivalentTo"} +xref: UMLS:C0030579 {source="DOID:10302", source="MONDO:equivalentTo"} +is_a: MONDO:0001142 {source="DOID:10302", source="EFO:0007422", source="MESH:D010305", source="MONDO:Entailed", source="MONDO:Redundant"} ! salivary gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +relationship: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch DOID:10302 +property_value: exactMatch http://identifiers.org/mesh/D010305 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030579 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0005900 +name: parotitis +def: "Inflammation of the parotid glands." [NCIT:P378] +synonym: "inflammation of parotid gland" EXACT [] +synonym: "parotid gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10301 {source="EFO:0007423", source="MONDO:equivalentTo"} +xref: EFO:0007423 {source="MONDO:equivalentTo"} +xref: MESH:D010309 {source="EFO:0007423", source="DOID:10301", source="MONDO:equivalentTo"} +xref: NCIT:C114281 {source="DOID:10301", source="MONDO:equivalentTo"} +xref: SCTID:14756005 {source="DOID:10301", source="MONDO:equivalentTo"} +xref: UMLS:C0030583 {source="DOID:10301", source="MONDO:equivalentTo", source="NCIT:C114281"} +is_a: MONDO:0005899 {source="DOID:10301", source="EFO:0007423", source="MESH:D010309", source="MONDO:Entailed", source="MONDO:Redundant"} ! parotid disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001831 ! parotid gland +relationship: disease_has_inflammation_site UBERON:0001831 ! parotid gland +property_value: exactMatch DOID:10301 +property_value: exactMatch http://identifiers.org/mesh/D010309 +property_value: exactMatch http://identifiers.org/snomedct/14756005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030583 +property_value: exactMatch NCIT:C114281 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0005904 +name: pericarditis +def: "An inflammatory process affecting the pericardium." [NCIT:P378] +synonym: "inflammation of pericardium" EXACT [] +synonym: "pericarditis" EXACT [MONDO:ambiguous] +synonym: "pericarditis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "pericardium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:1787 {source="EFO:0007427", source="MONDO:equivalentTo"} +xref: EFO:0007427 {source="MONDO:equivalentTo"} +xref: HP:0001701 {source="MONDO:otherHierarchy"} +xref: MESH:D010493 {source="EFO:0007427", source="MONDO:equivalentTo", source="DOID:1787"} +xref: NCIT:C34915 {source="MONDO:equivalentTo", source="DOID:1787"} +xref: Orphanet:58208 {source="MONDO:equivalentTo"} +xref: SCTID:3238004 {source="MONDO:equivalentTo", source="DOID:1787"} +xref: UMLS:C0031046 {source="NCIT:C34915", source="MONDO:equivalentTo", source="DOID:1787"} +is_a: MONDO:0000474 {source="DOID:1787", source="MONDO:Redundant"} ! pericardium disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002407 ! pericardium +relationship: disease_has_inflammation_site UBERON:0002407 ! pericardium +property_value: exactMatch DOID:1787 +property_value: exactMatch http://identifiers.org/mesh/D010493 +property_value: exactMatch http://identifiers.org/snomedct/3238004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0031046 +property_value: exactMatch NCIT:C34915 +property_value: exactMatch Orphanet:58208 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "pericarditis (disease)" xsd:string + +[Term] +id: MONDO:0005917 +name: placenta disorder +def: "A disease involving the placenta." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of placenta" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of placenta" EXACT [] +synonym: "disease, placenta" RELATED [MESH:D010922] +synonym: "disease, placental" RELATED [MESH:D010922] +synonym: "diseases, placenta" RELATED [MESH:D010922] +synonym: "diseases, placental" RELATED [MESH:D010922] +synonym: "disorder of placenta" EXACT [MONDO:patterns/location_top] +synonym: "disorder, placenta" RELATED [MESH:D010922] +synonym: "disorders, placenta" RELATED [MESH:D010922] +synonym: "placenta disease" EXACT [MESH:D010922, MONDO:patterns/location] +synonym: "placenta disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "placenta diseases" EXACT [NCIT:C26857] +synonym: "placenta disorder" EXACT [MESH:D010922, NCIT:C26857] +synonym: "placenta disorders" EXACT [MESH:D010922, NCIT:C26857] +synonym: "placental disease" RELATED [MESH:D010922] +synonym: "placental diseases" RELATED [MESH:D010922] +synonym: "placental disorder" EXACT [NCIT:C26857] +xref: DOID:780 {source="MONDO:equivalentTo"} +xref: EFO:0007441 {source="MONDO:equivalentTo"} +xref: GARD:0007402 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD9:646.9 {source="DOID:780"} +xref: ICD9:656.70 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010922 {source="MONDO:equivalentTo", source="DOID:780"} +xref: NCIT:C26857 {source="MONDO:equivalentTo", source="DOID:780"} +xref: NCIT:C34941 {source="MONDO:otherHierarchy", source="DOID:780"} +xref: SCTID:125586008 {source="MONDO:equivalentTo", source="DOID:780"} +is_a: MONDO:0002654 {source="DOID:780"} ! uterine disorder +is_a: MONDO:0024575 {source="MESH:D010922", source="NCIT:C26857"} ! pregnancy disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001987 ! placenta +relationship: disease_has_location UBERON:0001987 ! placenta +property_value: exactMatch DOID:780 +property_value: exactMatch http://identifiers.org/mesh/D010922 +property_value: exactMatch http://identifiers.org/snomedct/125586008 +property_value: exactMatch NCIT:C26857 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: relatedMatch NCIT:C34941 + +[Term] +id: MONDO:0005941 +name: retroperitoneal cancer +def: "A primary or metastatic malignant neoplasm involving the retroperitoneum. The vast majority of cases are carcinomas, lymphomas, or sarcomas." [NCIT:P378] +synonym: "cancer of retroperitoneal space" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of retroperitoneal space" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of retroperitoneum" RELATED [DOID:5875, ICD9CM:158.0] +synonym: "malignant neoplasm of retroperitoneum and peritoneum" EXACT [DOID:5875, ICD9CM:158] +synonym: "malignant retroperitoneal cancer" RELATED [DOID:5875] +synonym: "malignant retroperitoneal neoplasm" EXACT [NCIT:C3537] +synonym: "malignant retroperitoneal space neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of peritoneum and retroperitoneum" EXACT [DOID:5875] +synonym: "neoplasm of retroperitoneum" BROAD [DOID:5875] +synonym: "neoplasm of the retroperitoneum" BROAD [DOID:5875] +synonym: "retroperitoneal neoplasm" BROAD [DOID:5875, NCIT:C3357] +synonym: "retroperitoneal space cancer" EXACT [] +synonym: "tumor of retroperitoneum" BROAD [DOID:5875] +xref: DOID:5875 {source="EFO:0007466", source="MONDO:equivalentTo"} +xref: EFO:0007466 {source="MONDO:equivalentTo"} +xref: ICD9:158 {source="DOID:5875"} +xref: ICD9:158.0 {source="DOID:5875"} +xref: MESH:D012186 {source="EFO:0007466", source="DOID:5875", source="MONDO:equivalentTo"} +xref: NCIT:C3537 {source="DOID:5875", source="MONDO:equivalentTo"} +xref: SCTID:126872008 {source="DOID:5875", source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="DOID:5875", source="DOID:5875/inferred", source="EFO:0007466/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0024645 ! retroperitoneal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003693 ! retroperitoneal space +property_value: exactMatch DOID:5875 +property_value: exactMatch http://identifiers.org/mesh/D012186 +property_value: exactMatch http://identifiers.org/snomedct/126872008 +property_value: exactMatch NCIT:C3537 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005961 +name: sinusitis +def: "An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity." [NCIT:C35024] +xref: DOID:0050127 {source="MONDO:equivalentTo", source="EFO:0007486"} +xref: EFO:0007486 {source="MONDO:equivalentTo"} +xref: ICD9:461 {source="DOID:0050127"} +xref: ICD9:461.9 {source="DOID:0050127"} +xref: MESH:D012852 {source="MONDO:equivalentTo", source="EFO:0007486"} +xref: NCIT:C35024 {source="MONDO:equivalentTo"} +xref: SCTID:36971009 {source="MONDO:equivalentTo"} +xref: UMLS:C0037199 {source="MONDO:equivalentTo", source="NCIT:C35024"} +is_a: MONDO:0001735 {source="DOID:0050127", source="MESH:D012852", source="MONDO:Redundant", source="NCIT:C35024/inferred"} ! paranasal sinus disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001825 ! paranasal sinus +relationship: disease_has_inflammation_site UBERON:0001825 ! paranasal sinus +property_value: exactMatch DOID:0050127 +property_value: exactMatch http://identifiers.org/mesh/D012852 +property_value: exactMatch http://identifiers.org/snomedct/36971009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037199 +property_value: exactMatch NCIT:C35024 + +[Term] +id: MONDO:0005964 +name: sphenoid sinusitis +def: "An acute or chronic inflammatory process affecting the mucous membrane of the sphenoid sinus." [NCIT:P378] +synonym: "sinusitis of sphenoid bone" EXACT [MONDO:design_pattern] +synonym: "sphenoid bone sinusitis" EXACT [MONDO:patterns/location] +synonym: "sphenoidal sinusitis" EXACT [DOID:10794, NCIT:C35031] +xref: DOID:10794 {source="EFO:0007489", source="MONDO:equivalentTo"} +xref: EFO:0007489 {source="MONDO:equivalentTo"} +xref: MESH:D015524 {source="EFO:0007489", source="MONDO:equivalentTo", source="DOID:10794"} +xref: NCIT:C35031 {source="MONDO:equivalentTo", source="DOID:10794"} +xref: SCTID:13266007 {source="MONDO:equivalentTo", source="DOID:10794"} +xref: UMLS:C0037886 {source="NCIT:C35031", source="MONDO:equivalentTo", source="DOID:10794"} +is_a: MONDO:0005961 {source="DOID:10794", source="EFO:0007489", source="MESH:D015524", source="MONDO:Redundant", source="NCIT:C35031"} ! sinusitis +is_a: MONDO:0023369 ! disorder of facial skeleton +intersection_of: MONDO:0005961 ! sinusitis +intersection_of: disease_has_location UBERON:0001677 ! sphenoid bone +relationship: disease_has_location UBERON:0001677 ! sphenoid bone +property_value: exactMatch DOID:10794 +property_value: exactMatch http://identifiers.org/mesh/D015524 +property_value: exactMatch http://identifiers.org/snomedct/13266007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037886 +property_value: exactMatch NCIT:C35031 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0005966 +name: spleen cancer +def: "A malignant neoplasm involving the spleen" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of spleen" EXACT [MONDO:patterns/cancer] +synonym: "cancer of the spleen" EXACT [NCIT:C3539] +synonym: "malignant neoplasm of spleen" EXACT [MONDO:patterns/cancer, NCIT:C3539] +synonym: "malignant neoplasm of the spleen" EXACT [NCIT:C3539] +synonym: "malignant spleen neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant splenic neoplasm" EXACT [NCIT:C3539] +synonym: "malignant splenic tumor" EXACT [DOID:672, NCIT:C3539] +synonym: "malignant tumor of spleen" EXACT [NCIT:C3539] +synonym: "malignant tumor of the spleen" EXACT [NCIT:C3539] +synonym: "malignant tumour of spleen" EXACT [DOID:672] +synonym: "spleen cancer" EXACT [MONDO:patterns/location, NCIT:C3539] +synonym: "spleen neoplasm" BROAD [DOID:672] +synonym: "splenic cancer" EXACT [NCIT:C3539] +synonym: "splenic neoplasm" BROAD [DOID:672, NCIT:C3383] +xref: DOID:672 {source="MONDO:equivalentTo", source="EFO:0007491"} +xref: EFO:0007491 {source="MONDO:equivalentTo"} +xref: ICD10CM:C26.1 {source="MONDO:equivalentTo", source="DOID:672"} +xref: MESH:D013160 {source="MONDO:equivalentTo", source="EFO:0007491", source="DOID:672"} +xref: NCIT:C3539 {source="MONDO:equivalentTo", source="DOID:672"} +xref: SCTID:127230005 {source="MONDO:equivalentTo", source="DOID:672"} +is_a: MONDO:0000612 {source="DOID:672", source="MONDO:Entailed", source="MONDO:Redundant"} ! lymphatic system cancer +is_a: MONDO:0002516 {source="ICD10CM:C26.1/inferred", source="MONDO:Redundant"} ! digestive system cancer +is_a: MONDO:0036696 ! spleen neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002106 ! spleen +property_value: exactMatch DOID:672 +property_value: exactMatch http://identifiers.org/mesh/D013160 +property_value: exactMatch http://identifiers.org/snomedct/127230005 +property_value: exactMatch https://icd.codes/icd10cm/C26.1 +property_value: exactMatch NCIT:C3539 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0005990 +name: tracheitis +alt_id: MONDO:0020691 +def: "A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions." [DOID:9392] +synonym: "acute tracheitis" EXACT [DOID:9392, ICD9CM:464.1] +synonym: "chronic tracheitis" EXACT [DOID:9392] +synonym: "inflammation of tracheal mucosa" EXACT [] +synonym: "tracheal Inflammation" EXACT [NCIT:C78643] +synonym: "tracheal mucosa inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:9392 {source="MONDO:equivalentTo", source="EFO:0007518"} +xref: EFO:0007518 {source="MONDO:equivalentTo"} +xref: ICD10CM:J04.1 {source="MONDO:equivalentTo", source="DOID:9392"} +xref: ICD9:464.1 {source="DOID:9392"} +xref: MESH:D014136 {source="MONDO:equivalentTo", source="DOID:9392", source="EFO:0007518"} +xref: NCIT:C78643 {source="MONDO:equivalentTo", source="DOID:9392"} +xref: SCTID:62994001 {source="MONDO:equivalentTo", source="DOID:9392"} +xref: UMLS:C0040584 {source="MONDO:equivalentTo", source="DOID:9392", source="NCIT:C78643"} +xref: UMLS:C0149513 {source="MONDO:equivalentTo", source="DOID:9392"} +xref: UMLS:C0264322 {source="MONDO:equivalentTo"} +is_a: MONDO:0002567 {source="DOID:9392", source="MESH:D014136", source="NCIT:C78643/inferred"} ! tracheal disorder +is_a: MONDO:0005113 {source="EFO:0007518"} ! bacterial infectious disease +is_a: MONDO:0020579 ! mucositis +is_a: MONDO:0021925 ! tracheobronchitis +is_a: MONDO:0024355 ! respiratory tract infectious disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0003126 ! trachea +relationship: disease_has_inflammation_site UBERON:0000379 ! tracheal mucosa +relationship: disease_has_inflammation_site UBERON:0003126 ! trachea +property_value: exactMatch DOID:9392 +property_value: exactMatch http://identifiers.org/mesh/D014136 +property_value: exactMatch http://identifiers.org/snomedct/62994001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040584 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149513 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264322 +property_value: exactMatch https://icd.codes/icd10cm/J04.1 +property_value: exactMatch NCIT:C78643 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006004 +name: vasomotor rhinitis +def: "Inflammation in the nasal cavity mucosa that results from the abnormal regulation of the blood flow in the nose. It may be caused by temperature fluctuations, air pollution, strong odors, and tobacco smoke. It results in chronic nasal congestion, sneezing, and running nose." [NCIT:P378] +xref: DOID:4730 {source="EFO:0007533", source="MONDO:equivalentTo"} +xref: EFO:0007533 {source="MONDO:equivalentTo"} +xref: ICD10CM:J30.0 {source="DOID:4730", source="MONDO:equivalentTo"} +xref: MESH:D012223 {source="EFO:0007533", source="DOID:4730", source="MONDO:equivalentTo"} +xref: NCIT:C34988 {source="DOID:4730", source="MONDO:equivalentTo"} +xref: SCTID:8229003 {source="DOID:4730", source="MONDO:equivalentTo"} +xref: UMLS:C0035460 {source="DOID:4730", source="MONDO:equivalentTo", source="NCIT:C34988"} +is_a: MONDO:0011786 {source="EFO:0007533"} ! allergic rhinitis +intersection_of: MONDO:0003014 ! rhinitis +intersection_of: disease_has_basis_in_disruption_of GO:0019229 ! regulation of vasoconstriction +relationship: disease_has_basis_in_disruption_of GO:0019229 ! regulation of vasoconstriction +property_value: exactMatch DOID:4730 +property_value: exactMatch http://identifiers.org/mesh/D012223 +property_value: exactMatch http://identifiers.org/snomedct/8229003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035460 +property_value: exactMatch https://icd.codes/icd10cm/J30.0 +property_value: exactMatch NCIT:C34988 + +[Term] +id: MONDO:0006008 +name: vestibular neuronitis +def: "Idiopathic inflammation of the vestibular nerve, characterized clinically by the acute or subacute onset of vertigo; nausea; and imbalance. The cochlear nerve is typically spared and hearing loss and tinnitus do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)" [MESH:D020338] +synonym: "epidemic neurolabyrinthitis" EXACT [DOID:12683] +synonym: "vestibular neuritis" EXACT [DOID:12683] +xref: DOID:12683 {source="EFO:0007537", source="MONDO:equivalentTo"} +xref: EFO:0007537 {source="MONDO:equivalentTo"} +xref: ICD10CM:H81.2 {source="MONDO:equivalentTo", source="DOID:12683"} +xref: ICD9:078.81 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12683"} +xref: ICD9:386.12 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12683"} +xref: MESH:D020338 {source="EFO:0007537", source="MONDO:equivalentTo", source="DOID:12683"} +xref: SCTID:186738001 {source="MONDO:equivalentTo", source="DOID:12683"} +xref: UMLS:C0751908 {source="MONDO:equivalentTo", source="DOID:12683"} +is_a: MONDO:0001563 {source="DOID:12683", source="MESH:D020338", source="MONDO:Redundant"} ! vestibulocochlear nerve disorder +is_a: MONDO:0002122 ! neuritis +intersection_of: MONDO:0002122 ! neuritis +intersection_of: disease_has_inflammation_site UBERON:0003723 ! vestibular nerve +relationship: disease_has_inflammation_site UBERON:0003723 ! vestibular nerve +property_value: exactMatch DOID:12683 +property_value: exactMatch http://identifiers.org/mesh/D020338 +property_value: exactMatch http://identifiers.org/snomedct/186738001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751908 +property_value: exactMatch https://icd.codes/icd10cm/H81.2 + +[Term] +id: MONDO:0006009 +name: viral encephalitis +def: "Encephalitis resulting from viral infection." [NCIT:C35302] +comment: Editor note: we place the Orphanet class here as it is implicitly viral +synonym: "viral encephalitis" EXACT [NCIT:C35302] +synonym: "Viruses caused encephalitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses encephalitis" EXACT [] +xref: DOID:646 {source="MONDO:equivalentTo", source="EFO:0007538"} +xref: EFO:0007538 {source="MONDO:equivalentTo"} +xref: MedDRA:10058805 {source="Orphanet:98252/e", source="Orphanet:98252"} +xref: NCIT:C35302 {source="MONDO:equivalentTo"} +xref: Orphanet:98252 {source="MONDO:equivalentTo"} +xref: SCTID:34476008 {source="MONDO:equivalentTo"} +xref: UMLS:C0243010 {source="MONDO:equivalentTo", source="NCIT:C35302"} +is_a: MONDO:0020067 {source="MONDO:Redundant", source="NCIT:C35302"} ! infectious encephalitis +is_a: MONDO:0024318 ! viral infection of central nervous system +is_a: MONDO:0100329 ! primary viral infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0019956 ! encephalitis +intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +property_value: closeMatch http://identifiers.org/meddra/10058805 +property_value: exactMatch DOID:646 +property_value: exactMatch http://identifiers.org/snomedct/34476008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0243010 +property_value: exactMatch NCIT:C35302 +property_value: exactMatch Orphanet:98252 + +[Term] +id: MONDO:0006011 +name: viral hepatitis +def: "An acute or chronic inflammation of the liver parenchyma caused by viruses. Representative examples include hepatitis A, B, and C, cytomegalovirus hepatitis, and herpes simplex hepatitis." [NCIT:P378] +comment: Editor note: consider adding term for viral +synonym: "Hepatitis viral" EXACT [NCIT:C35124] +synonym: "human viral hepatitis" EXACT [DOID:1884] +synonym: "unspecified viral hepatitis with hepatic coma" NARROW [DOID:1884, ICD9CM:070.6] +synonym: "viral Hepatitis" EXACT [NCIT:C35124] +synonym: "viral hepatitis with hepatic coma" NARROW [DOID:1884] +synonym: "viral human hepatitis" EXACT [MONDO:0005343] +synonym: "Viruses caused hepatitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses hepatitis" EXACT [] +xref: DOID:1884 {source="MONDO:equivalentTo", source="EFO:0007540"} +xref: EFO:0004196 {source="MONDO:equivalentTo"} +xref: ICD10CM:B15-B19 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:573.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D006524 {source="DOID:1884", source="MONDO:NonHumanEquivalent"} +xref: MESH:D006525 {source="MONDO:equivalentTo", source="EFO:0004196"} +xref: NCIT:C35124 {source="MONDO:equivalentTo"} +xref: SCTID:3738000 {source="MONDO:equivalentTo"} +xref: UMLS:C0019194 {source="DOID:1884", source="MONDO:notFoundInDiseaseSubset", source="MONDO:NonHumanEquivalent"} +xref: UMLS:C0042721 {source="MONDO:equivalentTo", source="NCIT:C35124"} +is_a: MONDO:0002251 {source="DOID:1884", source="MESH:D006525", source="MONDO:Redundant", source="NCIT:C35124"} ! hepatitis +is_a: MONDO:0043424 ! digestive system infectious disorder +is_a: MONDO:0100329 ! primary viral infectious disease +intersection_of: MONDO:0002251 ! hepatitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +property_value: closeMatch http://linkedlifedata.com/resource/umls/id/C0019194 +property_value: exactMatch DOID:1884 +property_value: exactMatch http://identifiers.org/mesh/D006525 +property_value: exactMatch http://identifiers.org/snomedct/3738000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042721 +property_value: exactMatch https://icd.codes/icd10cm/B15-B19 +property_value: exactMatch NCIT:C35124 +property_value: excluded_synonym "animal viral hepatitis" xsd:string {source="DOID:1884"} + +[Term] +id: MONDO:0006026 +name: urinary bladder disorder +def: "A disease involving the urinary bladder." [https://orcid.org/0000-0002-6601-2165] +synonym: "bladder disease" EXACT [NCIT:C2900] +synonym: "bladder disorder" EXACT [NCIT:C2900] +synonym: "disease of urinary bladder" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of urinary bladder" EXACT [] +synonym: "disorder of urinary bladder" EXACT [MONDO:patterns/location_top] +synonym: "urinary bladder disease" EXACT [DOID:365, MONDO:patterns/location] +synonym: "urinary bladder disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "urinary bladder disorder" EXACT [NCIT:C2900] +xref: DOID:365 {source="MONDO:equivalentTo", source="EFO:1000018"} +xref: EFO:1000018 {source="MONDO:equivalentTo"} +xref: ICD9:596.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:596.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:365"} +xref: MESH:D001745 {source="MONDO:equivalentTo", source="DOID:365"} +xref: NCIT:C2900 {source="MONDO:equivalentTo", source="EFO:1000018", source="DOID:365"} +xref: SCTID:42643001 {source="MONDO:equivalentTo", source="DOID:365"} +xref: UMLS:C0005686 {source="MONDO:equivalentTo", source="EFO:1000018", source="DOID:365", source="NCIT:C2900"} +is_a: MONDO:0002118 {source="DOID:365", source="MESH:D001745", source="MONDO:Redundant", source="NCIT:C2900"} ! urinary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001255 ! urinary bladder +relationship: disease_has_location UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:365 +property_value: exactMatch http://identifiers.org/mesh/D001745 +property_value: exactMatch http://identifiers.org/snomedct/42643001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005686 +property_value: exactMatch NCIT:C2900 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0006028 +name: cecum adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the caecum" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of cecum" EXACT [DOID:3039, NCIT:C5543] +synonym: "adenocarcinoma of the cecum" EXACT [NCIT:C5543] +synonym: "caecum adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "cecal adenocarcinoma" EXACT [DOID:3039, NCIT:C5543] +synonym: "cecum adenocarcinoma" EXACT [NCIT:C5543] +xref: DOID:3039 {source="EFO:1000020", source="MONDO:equivalentTo"} +xref: EFO:1000020 {source="MONDO:equivalentTo"} +xref: NCIT:C5543 {source="EFO:1000020", source="MONDO:equivalentTo", source="DOID:3039", source="MONDO:exact-label-match"} +xref: SCTID:413446001 {source="EFO:1000020", source="MONDO:equivalentTo", source="DOID:3039"} +xref: UMLS:C1332866 {source="EFO:1000020", source="MONDO:equivalentTo", source="NCIT:C5543", source="DOID:3039"} +is_a: MONDO:0002271 {source="MONDO:Redundant", source="NCIT:C5543"} ! colon adenocarcinoma +is_a: MONDO:0006029 {source="DOID:3039", source="MONDO:Redundant", source="NCIT:C5543"} ! cecum carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:3039 +property_value: exactMatch http://identifiers.org/snomedct/413446001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332866 +property_value: exactMatch NCIT:C5543 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006029 +name: cecum carcinoma +def: "A carcinoma that arises from epithelial cells of the caecum" [https://orcid.org/0000-0002-6601-2165] +synonym: "caecum carcinoma" EXACT [DOID:1519, MONDO:patterns/location] +synonym: "carcinoma of caecum" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of cecum" EXACT [DOID:1519, NCIT:C3491] +synonym: "carcinoma of the cecum" EXACT [NCIT:C3491] +synonym: "cecal cancer" BROAD [DOID:1519, NCIT:C3491] +synonym: "cecum cancer" BROAD [NCIT:C3491] +synonym: "cecum carcinoma" EXACT [NCIT:C3491] +xref: DOID:1519 {source="EFO:1000021", source="MONDO:equivalentTo"} +xref: EFO:1000021 {source="MONDO:equivalentTo"} +xref: NCIT:C3491 {source="EFO:1000021", source="MONDO:equivalentTo", source="DOID:1519"} +xref: SCTID:255081007 {source="MONDO:equivalentTo", source="DOID:1519"} +xref: UMLS:C0149640 {source="NCIT:C3491", source="EFO:1000021", source="MONDO:equivalentTo", source="DOID:1519"} +is_a: MONDO:0002032 {source="MONDO:Redundant", source="NCIT:C3491"} ! colon carcinoma +is_a: MONDO:0002033 {source="DOID:1519", source="MONDO:Redundant", source="NCIT:C3491"} ! cecum cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch DOID:1519 +property_value: exactMatch http://identifiers.org/snomedct/255081007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149640 +property_value: exactMatch NCIT:C3491 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006030 +name: chronic cystitis +def: "Recurrent infections of the urinary bladder." [NCIT:P378] +synonym: "cystitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:1680 {source="EFO:1000023", source="MONDO:equivalentTo"} +xref: EFO:1000023 {source="MONDO:equivalentTo"} +xref: ICD9:595.2 {source="DOID:1680", source="MONDO:relatedTo", source="EFO:1000023", source="MONDO:i2s"} +xref: NCIT:C27008 {source="EFO:1000023", source="MONDO:equivalentTo"} +xref: SCTID:33655002 {source="EFO:1000023", source="MONDO:equivalentTo"} +xref: UMLS:C0221763 {source="EFO:1000023", source="MONDO:equivalentTo", source="NCIT:C27008"} +is_a: MONDO:0006032 {source="DOID:1680", source="EFO:1000023", source="MONDO:Redundant", source="NCIT:C27008"} ! cystitis +intersection_of: MONDO:0006032 ! cystitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch DOID:1680 +property_value: exactMatch http://identifiers.org/snomedct/33655002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0221763 +property_value: exactMatch NCIT:C27008 + +[Term] +id: MONDO:0006031 +name: chronic rhinosinusitis +def: "Chronic form of sinusitis." [MONDO:patterns/chronic] +synonym: "chronic sinusitis" EXACT [] +synonym: "sinusitis, chronic" EXACT [MONDO:design_pattern, MONDO:patterns/chronic] +xref: EFO:1000024 {source="MONDO:equivalentTo"} +xref: ICD9:473.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:473.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35151 {source="MONDO:equivalentTo"} +xref: PMID:25838086 {source="EFO:1000024"} +xref: SCTID:40055000 {source="MONDO:equivalentTo"} +xref: UMLS:C0149516 {source="MONDO:equivalentTo"} +is_a: MONDO:0005961 ! sinusitis +intersection_of: MONDO:0005961 ! sinusitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/40055000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149516 +property_value: exactMatch NCIT:C35151 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0006032 +name: cystitis +def: "Inflammation of the urinary bladder." [NCIT:P378] +synonym: "bladder infection" EXACT [NCIT:C26738] +synonym: "inflammation of urinary bladder" EXACT [] +synonym: "urinary bladder inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:1679 {source="EFO:1000025", source="MONDO:equivalentTo"} +xref: EFO:1000025 {source="MONDO:equivalentTo"} +xref: ICD9:595 {source="EFO:1000025", source="DOID:1679"} +xref: ICD9:595.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:595.9 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1679"} +xref: MESH:D003556 {source="EFO:1000025", source="MONDO:equivalentTo", source="DOID:1679"} +xref: NCIT:C26738 {source="EFO:1000025", source="MONDO:equivalentTo", source="DOID:1679"} +xref: SCTID:38822007 {source="EFO:1000025", source="MONDO:equivalentTo", source="DOID:1679"} +xref: UMLS:C0010692 {source="EFO:1000025", source="MONDO:equivalentTo", source="DOID:1679", source="NCIT:C26738"} +is_a: MONDO:0006026 {source="DOID:1679", source="EFO:1000025", source="MESH:D003556", source="MONDO:Redundant", source="NCIT:C26738/inferred"} ! urinary bladder disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001255 ! urinary bladder +relationship: disease_has_inflammation_site UBERON:0001255 ! urinary bladder +property_value: exactMatch DOID:1679 +property_value: exactMatch http://identifiers.org/mesh/D003556 +property_value: exactMatch http://identifiers.org/snomedct/38822007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010692 +property_value: exactMatch NCIT:C26738 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006036 +name: granulosa cell tumor +def: "A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle. There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile. The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms." [NCIT:C3070] +synonym: "granulosa cell neoplasm" EXACT [DOID:2999, NCIT:C3070] +synonym: "granulosa cell neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "granulosa cell tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3070] +synonym: "granulosa cell tumor, adult type" EXACT [DOID:2999] +synonym: "granulosa cell tumor, adult type (morphologic abnormality)" EXACT [DOID:2999] +synonym: "granulosa cell tumor, undetermined" RELATED [NCIT:C3070] +synonym: "granulosa cell tumour, sarcomatoid" EXACT [DOID:2999] +synonym: "GRCT" RELATED ABBREVIATION [ONCOTREE:GRCT] +synonym: "neoplasm of granulosa cell" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of granulosa cell" EXACT [MONDO:patterns/neoplasm] +xref: DOID:2999 {source="EFO:1000032", source="MONDO:equivalentTo"} +xref: EFO:1000032 {source="MONDO:equivalentTo"} +xref: MESH:D006106 {source="EFO:1000032", source="MONDO:equivalentTo", source="DOID:2999"} +xref: NCIT:C3070 {source="EFO:1000032", source="MONDO:equivalentTo", source="DOID:2999", source="NCIT:C3070"} +xref: ONCOTREE:GRCT {source="MONDO:equivalentTo"} +xref: UMLS:C0018206 {source="EFO:1000032", source="MONDO:equivalentTo", source="DOID:2999", source="NCIT:C3070"} +is_a: MONDO:0002082 {source="MONDO:Redundant", source="NCIT:C3070/inferred"} ! endocrine gland neoplasm +is_a: MONDO:0006055 {source="DOID:2999", source="EFO:1000032", source="NCIT:C3070"} ! sex cord-stromal tumor +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location CL:0000501 ! granulosa cell +relationship: disease_has_location CL:0000501 ! granulosa cell +property_value: exactMatch DOID:2999 +property_value: exactMatch http://identifiers.org/mesh/D006106 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0018206 +property_value: exactMatch NCIT:C3070 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006039 +name: infectious colitis +def: "A viral or bacterial infectious process affecting the large intestine." [NCIT:C78359] +synonym: "infectious colitis" EXACT [NCIT:C78359] +xref: EFO:1000035 {source="MONDO:equivalentTo"} +xref: NCIT:C78359 {source="MONDO:equivalentTo", source="EFO:1000035"} +xref: SCTID:39341005 {source="MONDO:equivalentTo", source="EFO:1000035"} +xref: UMLS:C0277524 {source="MONDO:equivalentTo", source="EFO:1000035", source="NCIT:C78359"} +is_a: MONDO:0005292 {source="EFO:1000035", source="MONDO:Redundant", source="NCIT:C78359"} ! colitis +is_a: MONDO:0043424 ! digestive system infectious disorder +intersection_of: MONDO:0005550 {source="EFO:0000784"} ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001155 {source="EFO:0000784"} ! colon +property_value: exactMatch http://identifiers.org/snomedct/39341005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0277524 +property_value: exactMatch NCIT:C78359 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006041 +name: lung carcinoid tumor +def: "A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis." [NCIT:C4038] +synonym: "carcinoid tumor (disease) of lung" EXACT [] +synonym: "carcinoid tumor of lung" EXACT [NCIT:C4038] +synonym: "carcinoid tumor of the lung" EXACT [NCIT:C4038] +synonym: "lung carcinoid" RELATED [ONCOTREE:LUCA] +synonym: "lung carcinoid tumor" EXACT [NCIT:C4038] +synonym: "lung carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "pulmonary carcinoid tumor" EXACT [NCIT:C4038] +xref: EFO:1000037 {source="MONDO:equivalentTo"} +xref: NCIT:C4038 {source="MONDO:equivalentTo", source="EFO:1000037", source="MONDO:exact-label-match"} +xref: ONCOTREE:LUCA {source="MONDO:equivalentTo"} +xref: SCTID:254627002 {source="MONDO:equivalentTo"} +xref: UMLS:C0280089 {source="MONDO:equivalentTo", source="NCIT:C4038", source="EFO:1000037"} +is_a: MONDO:0005369 {source="MONDO:Redundant", source="NCIT:C4038/inferred"} ! carcinoid tumor +is_a: MONDO:0005454 {source="MONDO:Redundant", source="NCIT:C4038", source="ONCOTREE:LUCA"} ! lung neuroendocrine neoplasm +intersection_of: MONDO:0005369 ! carcinoid tumor +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch http://identifiers.org/snomedct/254627002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280089 +property_value: exactMatch NCIT:C4038 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0006043 +name: metaplastic breast carcinoma +def: "A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells." [NCIT:C5164] +subset: ordo_disease {source="Orphanet:213531"} +synonym: "breast metaplastic carcinoma" RELATED [DOID:4680] +synonym: "metaplastic breast cancer" RELATED [GARD:0010804] +synonym: "metaplastic breast carcinoma" EXACT [NCIT:C5164] +synonym: "metaplastic carcinoma of breast" EXACT [DOID:4680, NCIT:C5164] +synonym: "metaplastic carcinoma of the breast" EXACT [DOID:4680, NCIT:C5164] +xref: DOID:4680 {source="EFO:1000040", source="MONDO:equivalentTo"} +xref: EFO:1000040 {source="MONDO:equivalentTo"} +xref: GARD:0010804 {source="MONDO:equivalentTo"} +xref: ICD10CM:C50.0 {source="Orphanet:213531", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.1 {source="Orphanet:213531", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.2 {source="Orphanet:213531", source="MONDO:relatedTo", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.3 {source="Orphanet:213531", source="MONDO:relatedTo", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.4 {source="Orphanet:213531", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.5 {source="Orphanet:213531", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.6 {source="Orphanet:213531", source="MONDO:relatedTo", source="Orphanet:213531/btnt"} +xref: ICD10CM:C50.8 {source="Orphanet:213531", source="Orphanet:213531/btnt"} +xref: NCIT:C5164 {source="EFO:1000040", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4680"} +xref: ONCOTREE:MBC {source="MONDO:equivalentTo"} +xref: Orphanet:213531 {source="MONDO:equivalentTo"} +xref: SCTID:763479005 {source="MONDO:equivalentTo"} +xref: UMLS:C1334708 {source="Orphanet:213531", source="EFO:1000040", source="NCIT:C5164", source="MONDO:equivalentTo", source="DOID:4680"} +is_a: MONDO:0006256 {source="NCIT:C5164"} ! invasive breast carcinoma +property_value: broadMatch https://icd.codes/icd10cm/C50.0 +property_value: broadMatch https://icd.codes/icd10cm/C50.1 +property_value: broadMatch https://icd.codes/icd10cm/C50.4 +property_value: broadMatch https://icd.codes/icd10cm/C50.5 +property_value: broadMatch https://icd.codes/icd10cm/C50.8 +property_value: exactMatch DOID:4680 +property_value: exactMatch http://identifiers.org/snomedct/763479005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334708 +property_value: exactMatch NCIT:C5164 +property_value: exactMatch Orphanet:213531 + +[Term] +id: MONDO:0006047 +name: pancreatic adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the pancreas" [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma - pancreas" EXACT [NCIT:C8294] +synonym: "adenocarcinoma of pancreas" EXACT [NCIT:C8294] +synonym: "adenocarcinoma of the pancreas" EXACT [DOID:4074, NCIT:C8294] +synonym: "PAAD" RELATED ABBREVIATION [ONCOTREE:PAAD] +synonym: "pancreas adenocarcinoma" EXACT [DOID:4074, MONDO:patterns/location, NCIT:C8294] +synonym: "pancreatic adenocarcinoma" EXACT [NCIT:C8294] +xref: DOID:4074 {source="EFO:1000044", source="MONDO:equivalentTo"} +xref: EFO:1000044 {source="MONDO:equivalentTo"} +xref: NCIT:C8294 {source="EFO:1000044", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:4074"} +xref: ONCOTREE:PAAD {source="MONDO:equivalentTo"} +xref: SCTID:700423003 {source="EFO:1000044", source="MONDO:equivalentTo", source="DOID:4074"} +xref: UMLS:C0281361 {source="EFO:1000044", source="MONDO:equivalentTo", source="NCIT:C8294", source="DOID:4074"} +is_a: MONDO:0004970 {source="DOID:4074", source="MONDO:Redundant", source="NCIT:C8294"} ! adenocarcinoma +is_a: MONDO:0005192 {source="DOID:4074", source="EFO:1000044", source="NCIT:C8294"} ! exocrine pancreatic carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001264 ! pancreas +property_value: exactMatch DOID:4074 +property_value: exactMatch http://identifiers.org/snomedct/700423003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0281361 +property_value: exactMatch NCIT:C8294 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006054 +name: reproductive system neoplasm +def: "A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system." [NCIT:C3674] +synonym: "neoplasm of reproductive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3674] +synonym: "neoplasm of the reproductive system" EXACT [NCIT:C3674] +synonym: "reproductive neoplasm" EXACT [NCIT:C3674] +synonym: "reproductive system neoplasm" EXACT [NCIT:C3674] +synonym: "reproductive system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "reproductive system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3674] +synonym: "reproductive tumor" EXACT [NCIT:C3674] +synonym: "tumor of reproductive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3674] +synonym: "tumor of the reproductive system" EXACT [NCIT:C3674] +xref: EFO:1000051 {source="MONDO:equivalentTo"} +xref: NCIT:C3674 {source="EFO:1000051", source="MONDO:equivalentTo"} +xref: UMLS:C0178830 {source="EFO:1000051", source="MONDO:equivalentTo", source="NCIT:C3674"} +is_a: MONDO:0005039 {source="MONDO:Redundant", source="NCIT:C3674"} ! reproductive system disorder +is_a: MONDO:0005070 {source="EFO:1000051", source="MONDO:Entailed", source="NCIT:C3674/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000990 ! reproductive system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0178830 +property_value: exactMatch NCIT:C3674 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006055 +name: sex cord-stromal tumor +def: "A neoplasm involving a sex cord." [MONDO:patterns/neoplasm] +synonym: "malignant testicular sex cord-stromal tumor" EXACT [DOID:192] +synonym: "neoplasm of sex cord" EXACT [MONDO:patterns/neoplasm] +synonym: "sex cord neoplasm" EXACT [] +synonym: "Sex cord stromal tumour" EXACT [DOID:192] +synonym: "sex cord tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3794] +synonym: "sex cord-gonadal stromal tumor" EXACT [NCIT:C3794] +synonym: "Sex cord-stromal neoplasm" EXACT [DOID:192, NCIT:C3794] +synonym: "Sex cord-stromal tumor" EXACT [DOID:192, MTH:NOCODE, NCIT:C3794] +synonym: "sex cord-stromal tumor" EXACT [MONDO:0005958, NCIT:C3794] +synonym: "Sex cord-stromal tumor, no ICD-O subtype" EXACT [DOID:192] +synonym: "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)" EXACT [DOID:192] +synonym: "specialized gonadal neoplasm" EXACT [DOID:192] +synonym: "specialized gonadal neoplasm (morphologic abnormality)" EXACT [DOID:192] +synonym: "specialized gonadal neoplasm NOS (morphologic abnormality)" EXACT [DOID:192] +synonym: "specialized gonadal tumor" EXACT [DOID:192] +synonym: "specialized gonadal tumor (qualifier value)" EXACT [DOID:192] +synonym: "tumor of sex cord" EXACT [MONDO:patterns/neoplasm] +xref: DOID:192 {source="MONDO:equivalentTo", source="EFO:0007483"} +xref: EFO:0007483 {source="MONDO:equivalentTo"} +xref: EFO:1000052 {source="MONDO:equivalentTo"} +xref: ICDO:8590/1 {source="NCIT:C3794"} +xref: NCIT:C3794 {source="EFO:1000052", source="DOID:192", source="MONDO:equivalentTo"} +xref: UMLS:C0206724 {source="EFO:1000052", source="DOID:192", source="MONDO:equivalentTo", source="NCIT:C3794"} +xref: UMLS:C1515289 {source="DOID:192", source="MONDO:equivalentTo"} +is_a: MONDO:0006054 {source="EFO:1000052", source="MONDO:Entailed", source="NCIT:C3794/inferred"} ! reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0005295 ! sex cord +relationship: disease_has_location UBERON:0005295 ! sex cord +property_value: exactMatch DOID:192 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206724 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1515289 +property_value: exactMatch NCIT:C3794 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006056 +name: squamous cell breast carcinoma +def: "A rare carcinoma that arises from the breast parenchyma and is entirely composed of squamous cells." [NCIT:C5177] +synonym: "breast primary squamous cell carcinoma" EXACT [DOID:5514] +synonym: "breast squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "metaplastic squamous cell carcinoma" RELATED [ONCOTREE:MSCC] +synonym: "primary squamous cell breast carcinoma" EXACT [NCIT:C5177] +synonym: "primary squamous cell carcinoma of breast" EXACT [DOID:5514, NCIT:C5177] +synonym: "primary squamous cell carcinoma of the breast" EXACT [DOID:5514, NCIT:C5177, NCIT:C5179] +synonym: "scc of breast" EXACT [DOID:5514, NCIT:C5177] +synonym: "scc of the breast" EXACT [NCIT:C5177] +synonym: "squamous breast carcinoma" EXACT [NCIT:C5177] +synonym: "squamous carcinoma of breast" EXACT [NCIT:C5177] +synonym: "squamous carcinoma of the breast" EXACT [NCIT:C5177] +synonym: "squamous cell breast carcinoma" EXACT [NCIT:C5177] +synonym: "squamous cell carcinoma of breast" EXACT [DOID:5514, NCIT:C5177] +synonym: "squamous cell carcinoma of the breast" EXACT [NCIT:C5177] +xref: DOID:5514 {source="EFO:1000053", source="MONDO:equivalentTo"} +xref: EFO:1000053 {source="MONDO:equivalentTo"} +xref: NCIT:C5177 {source="EFO:1000053", source="MONDO:equivalentTo", source="DOID:5514", source="MONDO:exact-label-match"} +xref: ONCOTREE:MSCC {source="MONDO:equivalentTo"} +xref: UMLS:C1336079 {source="EFO:1000053", source="NCIT:C5177", source="MONDO:equivalentTo", source="DOID:5514"} +is_a: MONDO:0005096 {source="DOID:5514", source="EFO:1000053", source="MONDO:Redundant", source="NCIT:C5177"} ! squamous cell carcinoma +is_a: MONDO:0006043 {source="DOID:5514", source="ONCOTREE:MSCC/inferred"} ! metaplastic breast carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:5514 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336079 +property_value: exactMatch NCIT:C5177 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006059 +name: nasal cavity squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the nasal cavity mucosa. Signs and symptoms include nasal fullness and obstruction, pain, epistaxis, and the presence of a nasal mass." [NCIT:C8192] +synonym: "nasal cavity squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C8192] +synonym: "squamous cell carcinoma of nasal cavity" EXACT [DOID:5515, NCIT:C8192] +synonym: "squamous cell carcinoma of the nasal cavity" EXACT [DOID:5515, NCIT:C8192] +xref: DOID:5515 {source="MONDO:equivalentTo", source="EFO:1000057"} +xref: EFO:1000057 {source="MONDO:equivalentTo"} +xref: NCIT:C8192 {source="DOID:5515", source="MONDO:equivalentTo", source="EFO:1000057", source="MONDO:exact-label-match"} +xref: UMLS:C0280333 {source="DOID:5515", source="MONDO:equivalentTo", source="EFO:1000057", source="NCIT:C8192"} +is_a: MONDO:0003212 {source="DOID:5515", source="MONDO:Redundant", source="NCIT:C8192"} ! nasal cavity carcinoma +is_a: MONDO:0010150 {source="EFO:1000057", source="MONDO:Redundant", source="NCIT:C8192/inferred"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch DOID:5515 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280333 +property_value: exactMatch NCIT:C8192 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006069 +name: ACTH-producing pituitary gland carcinoma +def: "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces corticotropin. It may be associated with Cushing disease." [NCIT:C5964] +synonym: "ACTH producing pituitary gland carcinoma" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing neoplasm of pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing neoplasm of pituitary gland" EXACT [MONDO:0003838] +synonym: "malignant ACTH producing neoplasm of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing neoplasm of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing pituitary gland neoplasm" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing pituitary gland tumor" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing pituitary neoplasm" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing pituitary tumor" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing tumor of pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing tumor of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing tumor of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH producing tumor of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting neoplasm of pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting neoplasm of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting neoplasm of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting neoplasm of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting pituitary gland tumor" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting pituitary neoplasm" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting pituitary tumor" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting tumor of pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting tumor of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting tumor of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant ACTH secreting tumor of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing neoplasm of pituitary" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing neoplasm of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing neoplasm of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing neoplasm of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing pituitary gland neoplasm" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing pituitary gland tumor" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing pituitary neoplasm" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing pituitary tumor" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing tumor of pituitary" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing tumor of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing tumor of the pituitary" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin producing tumor of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin secreting pituitary gland neoplasm" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin secreting pituitary gland tumor" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin secreting pituitary neoplasm" EXACT [NCIT:C5964] +synonym: "malignant adrenocorticotropin secreting pituitary tumor" EXACT [NCIT:C5964] +synonym: "malignant corticotropin secreting pituitary gland neoplasm" EXACT [NCIT:C5964] +synonym: "malignant Corticotropinoma of pituitary" EXACT [NCIT:C5964] +synonym: "malignant Corticotropinoma of pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant Corticotropinoma of the pituitary" EXACT [DOID:6276, NCIT:C5964] +synonym: "malignant Corticotropinoma of the pituitary gland" EXACT [NCIT:C5964] +synonym: "malignant pituitary Corticotropinoma" EXACT [NCIT:C5964] +synonym: "malignant pituitary gland Corticotropinoma" EXACT [NCIT:C5964] +xref: DOID:6276 {source="MONDO:equivalentTo"} +xref: EFO:1000067 {source="MONDO:equivalentTo"} +xref: NCIT:C5964 {source="EFO:1000067", source="MONDO:equivalentTo", source="DOID:6276"} +xref: UMLS:C1334556 {source="MONDO:equivalentTo", source="NCIT:C5964", source="DOID:6276"} +is_a: MONDO:0017582 ! pituitary adenocarcinoma +is_a: MONDO:0045058 ! ACTH-producing pituitary gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +intersection_of: realized_in GO:0051458 ! corticotropin secretion +relationship: disease_has_feature HP:0011043 ! Abnormality of circulating adrenocorticotropin level +property_value: exactMatch DOID:6276 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334556 +property_value: exactMatch NCIT:C5964 +property_value: excluded_subClassOf MONDO:0003604 {source="DOID:6276"} + +[Term] +id: MONDO:0006075 +name: adrenal gland myelolipoma +def: "A benign soft tissue lesion arising from the adrenal gland. It is composed of mature adipose and hematopoietic/lymphoid tissues." [NCIT:C3736] +synonym: "adrenal gland myelolipoma" EXACT [NCIT:C3736] +synonym: "Myelolipoma" EXACT [NCIT:C3736] +synonym: "MYELOLIPOMA, benign" EXACT [NCIT:C3736] +xref: EFO:1000074 {source="MONDO:equivalentTo"} +xref: ICDO:8870/0 {source="NCIT:C3736"} +xref: MESH:D018209 {source="MONDO:equivalentTo"} +xref: NCIT:C3736 {source="EFO:1000074", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:719049003 {source="MONDO:equivalentTo"} +xref: UMLS:C0206635 {source="MONDO:equivalentTo", source="NCIT:C3736"} +is_a: MONDO:0021511 {source="MONDO:Redundant"} ! benign neoplasm of adrenal gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_arises_from_structure CL:0000136 ! fat cell +intersection_of: disease_arises_from_structure UBERON:0034769 ! lymphomyeloid tissue +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +relationship: disease_arises_from_structure CL:0000136 ! fat cell +relationship: disease_arises_from_structure UBERON:0034769 ! lymphomyeloid tissue +property_value: exactMatch http://identifiers.org/mesh/D018209 +property_value: exactMatch http://identifiers.org/snomedct/719049003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206635 +property_value: exactMatch NCIT:C3736 + +[Term] +id: MONDO:0006077 +name: adrenal medullary hyperplasia +def: "A hyperplasia that involves the adrenal medulla." [MONDO:patterns/location] +synonym: "adrenal medulla hyperplasia" EXACT [MONDO:patterns/location] +xref: EFO:1000076 {source="MONDO:equivalentTo"} +xref: NCIT:C35838 {source="EFO:1000076", source="MONDO:equivalentTo"} +is_a: MONDO:0005043 {source="EFO:1000076", source="MONDO:Redundant", source="NCIT:C35838/inferred"} ! hyperplasia +is_a: MONDO:0005495 ! adrenal gland disorder +intersection_of: MONDO:0005043 ! hyperplasia +intersection_of: disease_has_location UBERON:0001236 ! adrenal medulla +relationship: disease_has_location UBERON:0001236 ! adrenal medulla +property_value: exactMatch NCIT:C35838 + +[Term] +id: MONDO:0006082 +name: anal squamous cell carcinoma +def: "A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC." [NCIT:C9161] +synonym: "anal squamous cell cancer" EXACT [NCIT:C9161] +synonym: "anal squamous cell carcinoma" EXACT [NCIT:C9161] +synonym: "ANSC" RELATED ABBREVIATION [ONCOTREE:ANSC] +synonym: "anus squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "epidermoid anal carcinoma" EXACT [DOID:5525, NCIT:C9161] +synonym: "epidermoid carcinoma of anus" EXACT [NCIT:C9161] +synonym: "epidermoid carcinoma of the anus" EXACT [NCIT:C9161] +synonym: "squamous cell anal carcinoma" EXACT [NCIT:C9161] +synonym: "squamous cell carcinoma - anus" EXACT [NCIT:C9161] +synonym: "squamous cell carcinoma of anus" EXACT [NCIT:C9161] +synonym: "squamous cell carcinoma of the anus" EXACT [NCIT:C9161] +xref: DOID:5525 {source="MONDO:equivalentTo"} +xref: EFO:1000081 {source="MONDO:equivalentTo"} +xref: NCIT:C9161 {source="MONDO:equivalentTo", source="DOID:5525", source="MONDO:exact-label-match", source="EFO:1000081"} +xref: ONCOTREE:ANSC {source="MONDO:equivalentTo"} +xref: UMLS:C1412036 {source="MONDO:equivalentTo", source="DOID:5525", source="NCIT:C9161"} +is_a: MONDO:0003199 {source="DOID:5525", source="MONDO:Redundant", source="NCIT:C9161"} ! anal carcinoma +is_a: MONDO:0018515 ! squamous cell carcinoma of rectum +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch DOID:5525 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1412036 +property_value: exactMatch NCIT:C9161 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006087 +name: appendix adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the vermiform appendix." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of appendix" EXACT [DOID:3608, NCIT:C7718] +synonym: "adenocarcinoma of the appendix" EXACT [NCIT:C7718] +synonym: "APAD" RELATED ABBREVIATION [ONCOTREE:APAD] +synonym: "appendiceal adenocarcinoma" EXACT [DOID:3608, NCIT:C7718] +synonym: "appendix adenocarcinoma" EXACT [NCIT:C7718] +synonym: "vermiform appendix adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3608 {source="MONDO:equivalentTo"} +xref: EFO:1000088 {source="MONDO:equivalentTo"} +xref: GARD:0010564 {source="MONDO:equivalentTo"} +xref: NCIT:C7718 {source="EFO:1000088", source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:3608"} +xref: ONCOTREE:APAD {source="MONDO:equivalentTo"} +xref: SCTID:413445002 {source="MONDO:equivalentTo", source="DOID:3608"} +xref: UMLS:C0238003 {source="MONDO:equivalentTo", source="NCIT:C7718", source="DOID:3608"} +is_a: MONDO:0003196 {source="DOID:3608", source="MONDO:Redundant", source="NCIT:C7718"} ! appendix carcinoma +is_a: MONDO:0006028 ! cecum adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:3608 +property_value: exactMatch http://identifiers.org/snomedct/413445002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238003 +property_value: exactMatch NCIT:C7718 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006091 +name: appendix neuroendocrine tumor G1 +def: "A well differentiated, low grade tumor with neuroendocrine differentiation that arises from the appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:P378] +synonym: "appendiceal carcinoid tumor" EXACT [NCIT:C4138] +synonym: "appendix carcinoid endocrine tumour" RELATED [DOID:0050911] +synonym: "appendix carcinoid tumor" EXACT [MONDO:0000526] +synonym: "appendix NET G1" EXACT [NCIT:C4138] +synonym: "appendix NET G1 (carcinoid)" EXACT [NCIT:C4138] +synonym: "appendix neuroendocrine tumor G1 (carcinoid)" EXACT [NCIT:C4138] +synonym: "carcinoid tumor of appendix" EXACT [NCIT:C4138] +synonym: "carcinoid tumor of the appendix" EXACT [NCIT:C4138] +synonym: "grade 1 neuroendocrine neoplasm of vermiform appendix" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "vermiform appendix carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "vermiform appendix carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "vermiform appendix NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "vermiform appendix neuroendocrine neoplasm G1" EXACT [] +synonym: "vermiform appendix neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: DOID:0050911 {source="MONDO:equivalentTo"} +xref: EFO:1000092 {source="MONDO:equivalentTo"} +xref: ICD9:209.11 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICDO:8240/1 {source="NCIT:C4138"} +xref: NCIT:C4138 {source="MONDO:equivalentTo", source="EFO:1000092"} +xref: SCTID:253002004 {source="MONDO:equivalentTo"} +xref: UMLS:C0334298 {source="MONDO:equivalentTo", source="NCIT:C4138"} +is_a: MONDO:0006126 ! cecum neuroendocrine tumor G1 +is_a: MONDO:0015066 {source="MONDO:Redundant", source="NCIT:C4138"} ! neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch DOID:0050911 +property_value: exactMatch http://identifiers.org/snomedct/253002004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334298 +property_value: exactMatch NCIT:C4138 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0001235 {source="DOID:0050911"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006093 +name: ascending colon neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the ascending colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C6427] +synonym: "ascending colon carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C6427] +synonym: "ascending colon carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "ascending colon NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C6427] +synonym: "ascending colon neuroendocrine neoplasm G1" EXACT [] +synonym: "ascending colon neuroendocrine tumor G1" EXACT [NCIT:C6427] +synonym: "ascending colon neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "carcinoid tumor of ascending colon" EXACT [NCIT:C6427] +synonym: "carcinoid tumor of the ascending colon" EXACT [NCIT:C6427] +synonym: "grade 1 neuroendocrine neoplasm of ascending colon" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000094 {source="MONDO:equivalentTo"} +xref: NCIT:C6427 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:1000094"} +xref: UMLS:C1332340 {source="MONDO:equivalentTo", source="NCIT:C6427"} +is_a: MONDO:0006155 {source="MONDO:Redundant", source="NCIT:C6427"} ! colon neuroendocrine tumor G1 +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001156 ! ascending colon +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +relationship: disease_has_location UBERON:0001156 ! ascending colon +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332340 +property_value: exactMatch NCIT:C6427 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006104 +name: benign carotid body paraganglioma +def: "A carotid body paraganglioma that is confined to the site of origin, without metastatic potential." [NCIT:C79950] +synonym: "benign carotid body paraganglioma" EXACT [NCIT:C79950] +synonym: "benign chemodectoma" RELATED [NCIT:C79950] +synonym: "carotid body paraganglioma, benign" EXACT [MONDO:patterns/benign] +synonym: "chemodectoma, benign" RELATED [NCIT:C79950] +xref: EFO:1000108 {source="MONDO:equivalentTo"} +xref: NCIT:C79950 {source="MONDO:equivalentTo", source="NCIT:C79950", source="EFO:1000108"} +xref: UMLS:C2698359 {source="MONDO:equivalentTo", source="NCIT:C79950"} +is_a: MONDO:0000627 ! benign endocrine neoplasm +is_a: MONDO:0021053 {source="MONDO:Redundant", source="NCIT:C79950"} ! carotid body paraganglioma +is_a: MONDO:0024286 ! benign blood vessel neoplasm +is_a: MONDO:0056804 ! benign neoplasm of peripheral nervous system +intersection_of: MONDO:0021053 ! carotid body paraganglioma +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2698359 +property_value: exactMatch NCIT:C79950 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0006105 +name: benign conjunctival neoplasm +def: "Abnormal growth of the cells of the conjunctiva without malignant characteristics." [NCIT:C3622] +synonym: "benign conjunctiva neoplasm" EXACT [NCIT:C3622] +synonym: "benign conjunctiva tumor" EXACT [NCIT:C3622] +synonym: "benign conjunctival neoplasm" EXACT [NCIT:C3622] +synonym: "benign conjunctival tumor" EXACT [NCIT:C3622] +synonym: "benign neoplasm of conjunctiva" EXACT [NCIT:C3622] +synonym: "benign neoplasm of the conjunctiva" EXACT [NCIT:C3622] +synonym: "benign tumor of conjunctiva" EXACT [NCIT:C3622] +synonym: "benign tumor of the conjunctiva" EXACT [NCIT:C3622] +synonym: "conjunctiva benign neoplasm" EXACT [MONDO:patterns/location] +xref: EFO:1000110 {source="MONDO:equivalentTo"} +xref: NCIT:C3622 {source="EFO:1000110", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92068002 {source="MONDO:equivalentTo"} +xref: UMLS:C0154025 {source="MONDO:equivalentTo", source="NCIT:C3622"} +is_a: MONDO:0020204 {source="EFO:1000110", source="MONDO:Redundant", source="NCIT:C3622"} ! conjunctival tumor +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C3622"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +property_value: exactMatch http://identifiers.org/snomedct/92068002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154025 +property_value: exactMatch NCIT:C3622 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0006106 +name: benign smooth muscle neoplasm +def: "A benign mesenchymal neoplasm arising from smooth muscle tissue." [NCIT:C6510] +synonym: "benign neoplasm of smooth muscle" EXACT [NCIT:C6510] +synonym: "benign neoplasm of the smooth muscle" EXACT [NCIT:C6510] +synonym: "benign smooth muscle neoplasm" EXACT [NCIT:C6510] +synonym: "benign smooth muscle tumor" EXACT [NCIT:C6510] +synonym: "benign tumor of smooth muscle" EXACT [NCIT:C6510] +synonym: "benign tumor of the smooth muscle" EXACT [NCIT:C6510] +synonym: "smooth muscle tissue benign neoplasm" EXACT [MONDO:patterns/location] +xref: EFO:1000121 {source="MONDO:equivalentTo"} +xref: NCIT:C6510 {source="EFO:1000121", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1332539 {source="MONDO:equivalentTo", source="NCIT:C6510"} +is_a: MONDO:0003061 {source="MONDO:Redundant", source="NCIT:C6510"} ! benign muscle neoplasm +is_a: MONDO:0006975 {source="EFO:1000121", source="NCIT:C6510"} ! smooth muscle tumor +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001135 ! smooth muscle tissue +relationship: disease_has_location UBERON:0001135 ! smooth muscle tissue +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332539 +property_value: exactMatch NCIT:C6510 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0006107 +name: benign thyroid gland neoplasm +def: "A benign neoplasm arising from the thyroid gland." [NCIT:C3628] +synonym: "benign neoplasm of the thyroid" EXACT [NCIT:C3628] +synonym: "benign neoplasm of the thyroid gland" EXACT [NCIT:C3628] +synonym: "benign neoplasm of thyroid" EXACT [NCIT:C3628] +synonym: "benign neoplasm of thyroid gland" EXACT [NCIT:C3628] +synonym: "benign neoplasm of thyroid glands" EXACT [NCIT:C3628] +synonym: "benign thyroid gland neoplasm" EXACT [NCIT:C3628] +synonym: "benign thyroid gland tumor" EXACT [NCIT:C3628] +synonym: "benign thyroid neoplasm" EXACT [NCIT:C3628] +synonym: "benign thyroid tumor" EXACT [NCIT:C3628] +synonym: "benign tumor of the thyroid" EXACT [NCIT:C3628] +synonym: "benign tumor of the thyroid gland" EXACT [NCIT:C3628] +synonym: "benign tumor of thyroid" EXACT [NCIT:C3628] +synonym: "benign tumor of thyroid gland" EXACT [NCIT:C3628] +synonym: "thyroid gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "thyroid neoplasm, benign" EXACT [NCIT:C3628] +xref: EFO:1000122 {source="MONDO:equivalentTo"} +xref: ICD9:226 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3628 {source="EFO:1000122", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:92439006 {source="MONDO:equivalentTo"} +xref: UMLS:C0154038 {source="NCIT:C3628", source="MONDO:equivalentTo"} +is_a: MONDO:0000627 {source="MONDO:Redundant"} ! benign endocrine neoplasm +is_a: MONDO:0015074 {source="MONDO:Redundant", source="NCIT:C3628"} ! thyroid tumor +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch http://identifiers.org/snomedct/92439006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154038 +property_value: exactMatch NCIT:C3628 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0006126 +name: cecum neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the cecum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C5501] +synonym: "caecal carcinoid tumor" EXACT [NCIT:C5501] +synonym: "caecum carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C5501] +synonym: "caecum carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "caecum NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "caecum neuroendocrine neoplasm G1" EXACT [] +synonym: "caecum neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "carcinoid tumor of cecum" EXACT [NCIT:C5501] +synonym: "carcinoid tumor of the cecum" EXACT [NCIT:C5501] +synonym: "cecal carcinoid tumor" EXACT [NCIT:C5501] +synonym: "cecum carcinoid tumor" EXACT [NCIT:C5501] +synonym: "cecum NET G1" EXACT [NCIT:C5501] +synonym: "cecum neuroendocrine tumor G1" EXACT [NCIT:C5501] +synonym: "grade 1 neuroendocrine neoplasm of caecum" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000154 {source="MONDO:equivalentTo"} +xref: NCIT:C5501 {source="EFO:1000154", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0854488 {source="MONDO:equivalentTo", source="NCIT:C5501"} +is_a: MONDO:0005694 {source="MONDO:Redundant", source="NCIT:C5501"} ! cecal neoplasm +is_a: MONDO:0006155 {source="MONDO:Redundant", source="NCIT:C5501"} ! colon neuroendocrine tumor G1 +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001153 ! caecum +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0854488 +property_value: exactMatch NCIT:C5501 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006130 +name: central nervous system neoplasm +def: "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia." [NCIT:C9293] +synonym: "brain/spinal cord tumor" EXACT [NCIT:C9293] +synonym: "central nervous system neoplasm" EXACT [NCIT:C9293] +synonym: "central nervous system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "central nervous system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C9293] +synonym: "CNS neoplasm" EXACT [NCIT:C9293] +synonym: "CNS tumor" EXACT [NCIT:C9293] +synonym: "neoplasm of central nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C9293] +synonym: "neoplasm of CNS" EXACT [NCIT:C9293] +synonym: "neoplasm of the central nervous system" EXACT [NCIT:C9293] +synonym: "tumor of central nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C9293] +synonym: "tumor of CNS" EXACT [NCIT:C9293] +synonym: "tumor of the central nervous system" EXACT [NCIT:C9293] +synonym: "tumor of the CNS" EXACT [NCIT:C9293] +xref: EFO:1000158 {source="MONDO:equivalentTo"} +xref: NCIT:C9293 {source="MONDO:equivalentTo", source="EFO:1000158"} +is_a: MONDO:0002602 {source="MONDO:Redundant", source="NCIT:C9293"} ! central nervous system disorder +is_a: MONDO:0021248 {source="MONDO:Redundant", source="NCIT:C9293"} ! nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch NCIT:C9293 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006143 +name: cervical squamous cell carcinoma +def: "A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis." [NCIT:P378] +subset: ordo_disease {source="Orphanet:213767"} +synonym: "cervical squamous cell cancer" EXACT [NCIT:C4028] +synonym: "cervical squamous cell carcinoma" EXACT [NCIT:C4028, Orphanet:213767] +synonym: "cervix squamous cell carcinoma" EXACT [NCIT:C4028] +synonym: "cervix uteri squamous cell carcinoma" EXACT [NCIT:C4028] +synonym: "CESC" RELATED ABBREVIATION [ONCOTREE:CESC] +synonym: "squamous cell carcinoma of cervix" EXACT [NCIT:C4028] +synonym: "squamous cell carcinoma of cervix uteri" EXACT [NCIT:C4028] +synonym: "squamous cell carcinoma of the cervix" EXACT [NCIT:C4028] +synonym: "squamous cell carcinoma of the cervix uteri" EXACT [DOID:3744, NCIT:C4028] +synonym: "squamous cell carcinoma of the uterine cervix" EXACT [NCIT:C4028] +synonym: "squamous cell carcinoma of uterine cervix" EXACT [NCIT:C4028] +synonym: "squamous cervical cancer" EXACT [NCIT:C4028] +synonym: "uterine cervix squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4028] +xref: DOID:3744 {source="EFO:1000172", source="MONDO:equivalentTo"} +xref: EFO:1000172 {source="MONDO:equivalentTo"} +xref: ICD10CM:C53.0 {source="MONDO:relatedTo", source="Orphanet:213767", source="Orphanet:213767/btnt"} +xref: ICD10CM:C53.1 {source="Orphanet:213767", source="Orphanet:213767/btnt"} +xref: ICD10CM:C53.8 {source="Orphanet:213767", source="Orphanet:213767/btnt"} +xref: NCIT:C4028 {source="EFO:1000172", source="DOID:3744", source="MONDO:equivalentTo"} +xref: ONCOTREE:CESC {source="MONDO:equivalentTo"} +xref: Orphanet:213767 {source="MONDO:equivalentTo"} +xref: SCTID:254886006 {source="DOID:3744", source="MONDO:equivalentTo"} +xref: UMLS:C0279671 {source="EFO:1000172", source="DOID:3744", source="MONDO:equivalentTo", source="Orphanet:213767", source="NCIT:C4028"} +is_a: MONDO:0005096 {source="EFO:1000172", source="MONDO:Redundant", source="NCIT:C4028"} ! squamous cell carcinoma +is_a: MONDO:0005131 {source="DOID:3744", source="EFO:1000172", source="MONDO:Redundant", source="NCIT:C4028"} ! cervical carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +property_value: broadMatch https://icd.codes/icd10cm/C53.1 +property_value: broadMatch https://icd.codes/icd10cm/C53.8 +property_value: exactMatch DOID:3744 +property_value: exactMatch http://identifiers.org/snomedct/254886006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279671 +property_value: exactMatch NCIT:C4028 +property_value: exactMatch Orphanet:213767 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006155 +name: colon neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C5497] +synonym: "carcinoid tumor of colon" EXACT [NCIT:C5497] +synonym: "carcinoid tumor of the colon" EXACT [NCIT:C5497] +synonym: "colon carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C5497] +synonym: "colon carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "colon NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C5497] +synonym: "colon neuroendocrine neoplasm G1" EXACT [] +synonym: "colon neuroendocrine tumor G1" EXACT [NCIT:C5497] +synonym: "colon neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "colonic carcinoid tumor" EXACT [NCIT:C5497] +synonym: "grade 1 neuroendocrine neoplasm of colon" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000188 {source="MONDO:equivalentTo"} +xref: NCIT:C5497 {source="EFO:1000188", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +is_a: MONDO:0006162 {source="MONDO:Redundant", source="NCIT:C5497"} ! colorectal neuroendocrine tumor G1 +is_a: MONDO:0015067 ! neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch NCIT:C5497 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006162 +name: colorectal neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the colon or rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C96160] +synonym: "colorectal carcinoid tumor" EXACT [NCIT:C96160] +synonym: "colorectal NET G1" EXACT [NCIT:C96160] +synonym: "colorectal neuroendocrine tumor G1" EXACT [NCIT:C96160] +synonym: "colorectum carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "colorectum NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "colorectum neuroendocrine neoplasm G1" EXACT [] +synonym: "colorectum neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "grade 1 neuroendocrine neoplasm of colorectum" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "large intestinal neuroendocrine tumor G1" EXACT [NCIT:C96160] +xref: EFO:1000195 {source="MONDO:equivalentTo"} +xref: NCIT:C96160 {source="EFO:1000195", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C3272611 {source="NCIT:C96160", source="MONDO:equivalentTo"} +is_a: MONDO:0005335 {source="EFO:1000195", source="MONDO:Redundant", source="NCIT:C96160/inferred"} ! colorectal neoplasm +is_a: MONDO:0021533 ! intestinal neuroendocrine tumor G1 +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0012652 ! colorectum +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3272611 +property_value: exactMatch NCIT:C96160 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006165 +name: colorectal squamous cell carcinoma +def: "A very rare colorectal carcinoma characterized by the presence of a malignant squamous cell infiltrate." [NCIT:C43588] +synonym: "colorectal (colon or rectal) squamous cell cancer" EXACT [NCIT:C43588] +synonym: "colorectal squamous cell cancer" EXACT [NCIT:C43588] +synonym: "colorectal squamous cell carcinoma" EXACT [NCIT:C43588] +synonym: "colorectum squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: EFO:1000198 {source="MONDO:equivalentTo"} +xref: NCIT:C43588 {source="EFO:1000198", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1707442 {source="MONDO:equivalentTo", source="NCIT:C43588"} +is_a: MONDO:0005096 {source="EFO:1000198", source="MONDO:Redundant", source="NCIT:C43588"} ! squamous cell carcinoma +is_a: MONDO:0024331 ! colorectal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0012652 ! colorectum +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1707442 +property_value: exactMatch NCIT:C43588 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006170 +name: conjunctival disorder +def: "Any disorder of the conjunctiva." [NCIT:C27605] +synonym: "conjunctiva disease" EXACT [MONDO:patterns/location] +synonym: "conjunctiva disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "conjunctival disease" EXACT [NCIT:C27605] +synonym: "conjunctival disorder" EXACT [NCIT:C27605] +synonym: "disease of conjunctiva" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of conjunctiva" EXACT [] +synonym: "disorder of conjunctiva" EXACT [MONDO:patterns/location_top] +xref: DOID:4251 {source="MONDO:equivalentTo"} +xref: EFO:1000203 {source="MONDO:equivalentTo"} +xref: ICD10CM:H10-H11 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: NCIT:C27605 {source="MONDO:equivalentTo", source="EFO:1000203"} +is_a: MONDO:0000462 ! eye adnexa disorder +is_a: MONDO:0005328 {source="EFO:1000203", source="NCIT:C27605"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +relationship: disease_has_location UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:4251 +property_value: exactMatch https://icd.codes/icd10cm/H10-H11 +property_value: exactMatch NCIT:C27605 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0006173 +name: conjunctival squamous cell carcinoma +def: "A low-grade squamous cell carcinoma that arises from the conjunctiva. It is the most common primary malignant tumor that arises from the conjunctiva. It usually affects older white males. Excessive exposure to sunlight is a risk factor. Patients may present with a mass, red eye, or pain." [NCIT:C4549] +synonym: "conjunctiva epidermoid carcinoma" EXACT [NCIT:C4549] +synonym: "conjunctiva squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4549] +synonym: "conjunctival epidermoid carcinoma" EXACT [DOID:1748, NCIT:C4549] +synonym: "conjunctival squamous cell cancer" EXACT [NCIT:C4549] +synonym: "conjunctival squamous cell carcinoma" EXACT [NCIT:C4549] +synonym: "epidermoid carcinoma of conjunctiva" EXACT [NCIT:C4549] +synonym: "epidermoid carcinoma of the conjunctiva" EXACT [NCIT:C4549] +synonym: "invasive squamous cell carcinoma of the conjunctiva" EXACT [DOID:1748] +synonym: "ocular surface squamous neoplasia" EXACT [DOID:1748] +synonym: "squamous cell carcinoma of conjunctiva" EXACT [DOID:1748, NCIT:C4549] +synonym: "squamous cell carcinoma of the conjunctiva" EXACT [NCIT:C4549] +xref: DOID:1748 {source="MONDO:equivalentTo"} +xref: EFO:1000206 {source="MONDO:equivalentTo"} +xref: NCIT:C4549 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="DOID:1748", source="EFO:1000206"} +xref: SCTID:255003007 {source="MONDO:equivalentTo", source="DOID:1748"} +xref: UMLS:C0346359 {source="MONDO:equivalentTo", source="DOID:1748", source="NCIT:C4549"} +is_a: MONDO:0002466 {source="MONDO:Redundant", source="NCIT:C4549"} ! eye carcinoma +is_a: MONDO:0003454 {source="DOID:1748", source="MONDO:Redundant", source="NCIT:C4549"} ! conjunctival cancer +is_a: MONDO:0010150 {source="MONDO:Redundant"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +property_value: exactMatch DOID:1748 +property_value: exactMatch http://identifiers.org/snomedct/255003007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346359 +property_value: exactMatch NCIT:C4549 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006176 +name: cribriform carcinoma +def: "A carcinoma characterized by the presence of a cribriform architectural pattern. Representative examples include the intraductal cribriform breast carcinoma and invasive cribriform breast carcinoma." [NCIT:C3680] +synonym: "cribriform carcinoma" EXACT [NCIT:C3680] +xref: EFO:1000210 {source="MONDO:equivalentTo"} +xref: ICDO:8201/3 {source="NCIT:C3680"} +xref: NCIT:C3680 {source="EFO:1000210", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0205643 {source="NCIT:C3680", source="MONDO:equivalentTo"} +is_a: MONDO:0004993 {source="EFO:1000210", source="MONDO:Redundant", source="NCIT:C3680"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_feature NCIT:C35920 ! Cribriform Pattern +relationship: disease_has_feature NCIT:C35920 ! Cribriform Pattern +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0205643 +property_value: exactMatch NCIT:C3680 + +[Term] +id: MONDO:0006181 +name: digestive system carcinoma +def: "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma." [NCIT:C96963] +synonym: "carcinoma of digestive system" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the gastrointestinal system" EXACT [NCIT:C96963] +synonym: "digestive system carcinoma" EXACT [NCIT:C96963] +synonym: "gastrointestinal carcinoma" EXACT [MONDO:ambiguous] +synonym: "gastrointestinal carcinoma (disease)" EXACT [MONDO:0000537] +synonym: "gastrointestinal system carcinoma" EXACT [NCIT:C96963] +xref: DOID:0050922 {source="MONDO:equivalentTo"} +xref: EFO:1000218 {source="MONDO:equivalentTo"} +xref: HP:0002672 {source="MONDO:otherHierarchy"} +xref: NCIT:C96963 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:1000218"} +xref: UMLS:C0151544 {source="MONDO:equivalentTo", source="NCIT:C96963"} +is_a: MONDO:0002516 {source="DOID:0050922", source="MONDO:Redundant", source="NCIT:C96963"} ! digestive system cancer +is_a: MONDO:0004993 {source="EFO:1000218", source="MONDO:Redundant", source="NCIT:C96963"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001007 ! digestive system +property_value: exactMatch DOID:0050922 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151544 +property_value: exactMatch NCIT:C96963 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006186 +name: duodenal adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the duodenum." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of duodenum" EXACT [DOID:10816, NCIT:C7889] +synonym: "adenocarcinoma of the duodenum" EXACT [NCIT:C7889] +synonym: "duodenal adenocarcinoma" EXACT [DOID:10816, NCIT:C7889] +synonym: "duodenum adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:10816 {source="MONDO:equivalentTo"} +xref: EFO:1000223 {source="MONDO:equivalentTo"} +xref: NCIT:C7889 {source="EFO:1000223", source="MONDO:equivalentTo", source="DOID:10816", source="MONDO:exact-label-match"} +xref: ONCOTREE:DA {source="MONDO:equivalentTo"} +xref: SCTID:408644002 {source="MONDO:equivalentTo", source="DOID:10816"} +xref: UMLS:C0278804 {source="MONDO:equivalentTo", source="DOID:10816", source="NCIT:C7889"} +is_a: MONDO:0003198 {source="DOID:10816", source="EFO:1000223", source="MONDO:Redundant", source="NCIT:C7889"} ! small intestine adenocarcinoma +is_a: MONDO:0021335 {source="MONDO:Redundant", source="NCIT:C7889"} ! carcinoma of duodenum +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: exactMatch DOID:10816 +property_value: exactMatch http://identifiers.org/snomedct/408644002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278804 +property_value: exactMatch NCIT:C7889 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006190 +name: endolymphatic sac tumor +def: "An aggressive epithelial neoplasm arising from the temporal bone. It is characterized by the presence of a papillary pattern, and has been described as an adenoma or carcinoma in the literature. There is disagreement regarding its relationship to endolymphatic sac tumor." [NCIT:P378] +synonym: "aggressive papillary tumor of the temporal bone" EXACT [NCIT:C67560] +synonym: "ELST" EXACT ABBREVIATION [NCIT:C67560] +synonym: "endolymphatic sac neoplasm" EXACT [] +synonym: "endolymphatic sac neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "endolymphatic sac tumor" EXACT [MONDO:ambiguous, MONDO:patterns/neoplasm, NCIT:C67560] +synonym: "endolymphatic sac tumor (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "neoplasm of endolymphatic sac" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of endolymphatic sac" EXACT [MONDO:patterns/neoplasm] +xref: EFO:1000230 {source="MONDO:equivalentTo"} +xref: GARD:0009270 {source="MONDO:equivalentTo"} +xref: HP:0030393 {source="MONDO:otherHierarchy"} +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8260/1 {source="NCIT:C67560"} +xref: NCIT:C67560 {source="EFO:1000230", source="MONDO:equivalentTo"} +xref: SCTID:699817008 {source="MONDO:equivalentTo"} +xref: UMLS:C2348239 {source="NCIT:C67560", source="MONDO:equivalentTo"} +is_a: MONDO:0021096 {source="NCIT:C67560"} ! papillary epithelial neoplasm +is_a: MONDO:0024320 ! inner ear neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002223 ! endolymphatic sac +relationship: disease_has_location UBERON:0002223 ! endolymphatic sac +property_value: exactMatch http://identifiers.org/snomedct/699817008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2348239 +property_value: exactMatch NCIT:C67560 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0000589 "endolymphatic sac tumor (disease)" xsd:string + +[Term] +id: MONDO:0006198 +name: endometrial squamous cell carcinoma +def: "A primary carcinoma of the endometrium characterized by the presence of malignant squamous cells." [NCIT:C8719] +synonym: "endometrial squamous cell carcinoma" EXACT [NCIT:C8719] +synonym: "endometrium squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of endometrium" EXACT [DOID:5533, NCIT:C8719] +synonym: "squamous cell carcinoma of the endometrium" EXACT [NCIT:C8719] +xref: DOID:5533 {source="MONDO:equivalentTo"} +xref: EFO:1000240 {source="MONDO:equivalentTo"} +xref: NCIT:C8719 {source="DOID:5533", source="EFO:1000240", source="MONDO:equivalentTo"} +xref: UMLS:C1333396 {source="DOID:5533", source="MONDO:equivalentTo"} +is_a: MONDO:0002447 {source="DOID:5533", source="MONDO:Redundant", source="NCIT:C8719"} ! endometrial carcinoma +is_a: MONDO:0005096 {source="DOID:5533", source="EFO:1000240", source="MONDO:Redundant", source="NCIT:C8719"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch DOID:5533 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333396 +property_value: exactMatch NCIT:C8719 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006203 +name: extrahepatic bile duct squamous cell carcinoma +def: "A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells." [NCIT:C5777] +synonym: "bile duct squamous cell carcinoma" BROAD [NCIT:C5777] +synonym: "extrahepatic bile duct squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C5777] +synonym: "squamous cell bile duct carcinoma" BROAD [NCIT:C5777] +synonym: "squamous cell carcinoma of bile duct" BROAD [NCIT:C5777] +synonym: "squamous cell carcinoma of the bile duct" BROAD [NCIT:C5777] +xref: EFO:1000248 {source="MONDO:equivalentTo"} +xref: NCIT:C5777 {source="MONDO:equivalentTo", source="EFO:1000248"} +xref: UMLS:C0861861 {source="NCIT:C5777", source="MONDO:directSiblingOf"} +is_a: MONDO:0003090 {source="MONDO:Redundant", source="NCIT:C5777"} ! extrahepatic bile duct carcinoma +is_a: MONDO:0003500 ! squamous cell bile duct carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0003703 ! extrahepatic bile duct +property_value: exactMatch NCIT:C5777 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006206 +name: fallopian tube carcinoma +def: "A carcinoma that arises from epithelial cells of the fallopian tube." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of fallopian tube" BROAD [NCIT:C3867] +synonym: "cancer of the fallopian tube" BROAD [DOID:1963, NCIT:C3867] +synonym: "carcinoma of fallopian tube" EXACT [MONDO:patterns/carcinoma, NCIT:C3867] +synonym: "carcinoma of the fallopian tube" EXACT [NCIT:C3867] +synonym: "fallopian tube Ca" EXACT [DOID:1963] +synonym: "fallopian tube cancer" BROAD [NCIT:C3867] +synonym: "fallopian tube carcinoma" EXACT [MONDO:patterns/location, NCIT:C3867] +xref: DOID:1963 {source="MONDO:equivalentTo"} +xref: EFO:1000251 {source="MONDO:equivalentTo"} +xref: NCIT:C3867 {source="EFO:1000251", source="MONDO:equivalentTo", source="DOID:1963"} +xref: SCTID:276870001 {source="MONDO:equivalentTo", source="DOID:1963"} +xref: UMLS:C0238122 {source="MONDO:equivalentTo", source="DOID:1963", source="NCIT:C3867"} +is_a: MONDO:0002158 {source="DOID:1963", source="MONDO:Redundant", source="NCIT:C3867"} ! fallopian tube cancer +is_a: MONDO:0004993 {source="DOID:1963", source="EFO:1000251", source="MONDO:Redundant", source="NCIT:C3867"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch DOID:1963 +property_value: exactMatch http://identifiers.org/snomedct/276870001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238122 +property_value: exactMatch NCIT:C3867 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006209 +name: fibroblastic neoplasm +def: "A benign, intermediate, or malignant mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts." [NCIT:C7075] +synonym: "fibroblastic neoplasm" EXACT [NCIT:C7075] +synonym: "fibroblastic tumor" EXACT [NCIT:C7075] +synonym: "fibrocytic neoplasm" EXACT [NCIT:C7075] +synonym: "fibrocytic tumor" EXACT [NCIT:C7075] +synonym: "fibrogenic neoplasm" EXACT [NCIT:C7075] +synonym: "fibrogenicTumor" EXACT [NCIT:C7075] +synonym: "fibrous neoplasm" EXACT [NCIT:C7075] +synonym: "fibrous tumor" EXACT [NCIT:C7075] +xref: EFO:1000255 {source="MONDO:equivalentTo"} +xref: NCIT:C7075 {source="MONDO:equivalentTo", source="EFO:1000255"} +is_a: MONDO:0002616 {source="MONDO:Redundant", source="NCIT:C7075"} ! mesenchymal cell neoplasm +is_a: MONDO:0021581 ! connective tissue neoplasm +intersection_of: MONDO:0002616 {source="NCIT:C7075"} ! mesenchymal cell neoplasm +intersection_of: disease_arises_from_structure CL:0000057 {source="NCIT:C7075"} ! fibroblast +relationship: disease_arises_from_structure CL:0000057 ! fibroblast +relationship: disease_has_location CL:0000057 {source="EFO:0000784"} ! fibroblast +property_value: exactMatch NCIT:C7075 + +[Term] +id: MONDO:0006215 +name: gallbladder adenocarcinoma +def: "A carcinoma that arises from glandular epithelial cells of the gall bladder." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of gallbladder" EXACT [NCIT:C9166] +synonym: "adenocarcinoma of the gallbladder" EXACT [DOID:3500, NCIT:C9166] +synonym: "gall bladder adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "gallbladder adenocarcinoma" EXACT [NCIT:C9166] +xref: DOID:3500 {source="MONDO:equivalentTo"} +xref: EFO:1000262 {source="MONDO:equivalentTo"} +xref: NCIT:C9166 {source="EFO:1000262", source="DOID:3500", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0279651 {source="NCIT:C9166", source="DOID:3500", source="MONDO:equivalentTo"} +is_a: MONDO:0003220 {source="DOID:3500", source="MONDO:Redundant", source="NCIT:C9166"} ! gallbladder carcinoma +is_a: MONDO:0004970 {source="DOID:3500", source="EFO:1000262", source="MONDO:Redundant", source="NCIT:C9166"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:3500 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279651 +property_value: exactMatch NCIT:C9166 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006220 +name: gallbladder squamous cell carcinoma +def: "A carcinoma that arises from the gallbladder. It is composed entirely by malignant squamous epithelial cells." [NCIT:C9170] +synonym: "epidermoid carcinoma of gallbladder" EXACT [NCIT:C9170] +synonym: "epidermoid carcinoma of the gallbladder" EXACT [NCIT:C9170] +synonym: "epidermoid gallbladder carcinoma" EXACT [DOID:5535, NCIT:C9170] +synonym: "gall bladder squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "gallbladder squamous cell cancer" EXACT [NCIT:C9170] +synonym: "gallbladder squamous cell carcinoma" EXACT [NCIT:C9170] +synonym: "squamous cell carcinoma of gallbladder" EXACT [NCIT:C9170] +synonym: "squamous cell carcinoma of the gallbladder" EXACT [DOID:5535, NCIT:C9170] +synonym: "squamous cell gallbladder carcinoma" EXACT [NCIT:C9170] +xref: DOID:5535 {source="MONDO:equivalentTo"} +xref: EFO:1000267 {source="MONDO:equivalentTo"} +xref: NCIT:C9170 {source="DOID:5535", source="EFO:1000267", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0279658 {source="DOID:5535", source="MONDO:equivalentTo", source="NCIT:C9170"} +is_a: MONDO:0003220 {source="DOID:5535", source="MONDO:Redundant", source="NCIT:C9170"} ! gallbladder carcinoma +is_a: MONDO:0005096 {source="DOID:5535", source="EFO:1000267", source="MONDO:Redundant", source="NCIT:C9170"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:5535 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279658 +property_value: exactMatch NCIT:C9170 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006226 +name: gastric mucosa-associated lymphoid tissue lymphoma +def: "A low grade, indolent B-cell lymphoma, usually associated with Helicobacter pylori infection. Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation. Approximately 40% of gastric MALT lymphomas carry the t(11;18)(q21;q21). Such cases are resistant to Helicobacter pylori therapy." [NCIT:C5266] +synonym: "gastric MALT lymphoma" EXACT [NCIT:C5266] +synonym: "gastric MALToma" EXACT [NCIT:C5266] +synonym: "gastric mucosa-associated lymphoid tissue lymphoma" EXACT [NCIT:C5266] +synonym: "MALT lymphoma of stomach" EXACT [NCIT:C5266] +synonym: "MALT lymphoma of the stomach" EXACT [NCIT:C5266] +synonym: "MALToma of stomach" EXACT [NCIT:C5266] +synonym: "MALToma of the stomach" EXACT [NCIT:C5266] +synonym: "primary gastric B-cell MALT lymphoma" EXACT [NCIT:C5266] +synonym: "primary gastric MALT lymphoma" EXACT [NCIT:C5266] +synonym: "primary MALT lymphoma of stomach" EXACT [NCIT:C5266] +synonym: "primary MALT lymphoma of the stomach" EXACT [NCIT:C5266] +synonym: "stomach MALT lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: EFO:1000274 {source="MONDO:equivalentTo"} +xref: NCIT:C5266 {source="EFO:1000274", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1333782 {source="NCIT:C5266", source="MONDO:equivalentTo"} +is_a: MONDO:0007650 {source="MONDO:Redundant", source="NCIT:C5266"} ! MALT lymphoma +is_a: MONDO:0018502 ! hereditary gastric cancer +is_a: MONDO:0042493 ! gastric non-hodgkin lymphoma +intersection_of: MONDO:0007650 ! MALT lymphoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333782 +property_value: exactMatch NCIT:C5266 + +[Term] +id: MONDO:0006227 +name: gastric neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the stomach. The vast majority of cases arise from the corpus-fundus region. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. It may be associated with autoimmune chronic atrophic gastritis, multiple endocrine neoplasia type 1, or it may be sporadic." [NCIT:P378] +synonym: "gastric carcinoid tumor" EXACT [NCIT:C4635] +synonym: "gastric ECL cell NET" EXACT [NCIT:C4635] +synonym: "gastric ECL cell NET G1" EXACT [NCIT:C4635] +synonym: "gastric ECL cell, histamine-producing NET" EXACT [NCIT:C4635] +synonym: "gastric ECL-cell carcinoid tumor" EXACT [NCIT:C4635] +synonym: "gastric enterochromaffin-like cell carcinoid tumor" EXACT [NCIT:C4635] +synonym: "gastric enterochromaffin-like cell neuroendocrine tumor" EXACT [NCIT:C4635] +synonym: "gastric NET G1" EXACT [NCIT:C4635] +synonym: "grade 1 neuroendocrine neoplasm of stomach" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "stomach carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "stomach NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "stomach neuroendocrine neoplasm G1" EXACT [] +synonym: "stomach neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000275 {source="MONDO:equivalentTo"} +xref: NCIT:C4635 {source="EFO:1000275", source="MONDO:equivalentTo"} +xref: UMLS:C0349529 {source="MONDO:equivalentTo", source="NCIT:C4635"} +is_a: MONDO:0005369 {source="EFO:1000275", source="MONDO:Redundant", source="NCIT:C4635/inferred"} ! carcinoid tumor +is_a: MONDO:0015062 {source="NCIT:C4635"} ! gastric neuroendocrine tumor, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000945 ! stomach +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +relationship: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349529 +property_value: exactMatch NCIT:C4635 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006230 +name: gastric squamous cell carcinoma +def: "A rare carcinoma of the stomach resembling squamous cell carcinomas arising elsewhere in the body." [NCIT:C5475] +subset: ordo_disease {source="Orphanet:418959"} +synonym: "gastric (stomach) squamous cell cancer" EXACT [NCIT:C5475] +synonym: "gastric squamous cell carcinoma" EXACT [NCIT:C5475, Orphanet:418959] +synonym: "squamous cell carcinoma of stomach" EXACT [DOID:5516, MONDO:0018482, NCIT:C5475] +synonym: "squamous cell carcinoma of the stomach" EXACT [NCIT:C5475] +synonym: "stomach squamous cell carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:5516 {source="MONDO:equivalentTo"} +xref: EFO:1000278 {source="MONDO:equivalentTo"} +xref: NCIT:C5475 {source="EFO:1000278", source="MONDO:equivalentTo", source="DOID:5516"} +xref: Orphanet:418959 {source="MONDO:equivalentTo"} +xref: SCTID:766980008 {source="MONDO:equivalentTo"} +xref: UMLS:C1333789 {source="NCIT:C5475", source="MONDO:equivalentTo", source="DOID:5516"} +xref: UMLS:CN237470 {source="MONDO:equivalentTo"} +is_a: MONDO:0004950 {source="DOID:5516", source="EFO:1000278", source="MONDO:Redundant", source="NCIT:C5475", source="Orphanet:418959"} ! gastric carcinoma +is_a: MONDO:0005096 {source="DOID:5516", source="EFO:1000278", source="MONDO:Redundant", source="NCIT:C5475"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch DOID:5516 +property_value: exactMatch http://identifiers.org/snomedct/766980008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333789 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237470 +property_value: exactMatch NCIT:C5475 +property_value: exactMatch Orphanet:418959 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006239 +name: head and neck paraganglioma +def: "A benign or malignant extra-adrenal paraganglioma arising from paraganglia in the head and neck. Representative examples include the carotid body and jugulotympanic paragangliomas." [NCIT:C5327] +synonym: "craniocervical region paraganglioma" EXACT [MONDO:patterns/location] +synonym: "head and neck paraganglioma" EXACT [NCIT:C5327] +synonym: "paraganglioma of craniocervical region" EXACT [MONDO:design_pattern] +synonym: "paraganglioma of head and neck" EXACT [NCIT:C5327] +synonym: "paraganglioma of the head and neck" EXACT [NCIT:C5327] +xref: EFO:1000288 {source="MONDO:equivalentTo"} +xref: NCIT:C5327 {source="MONDO:equivalentTo", source="EFO:1000288", source="MONDO:exact-label-match"} +xref: UMLS:C1333944 {source="MONDO:equivalentTo", source="NCIT:C5327"} +is_a: MONDO:0000448 {source="MONDO:Redundant", source="NCIT:C5327/inferred"} ! paraganglioma +is_a: MONDO:0005586 {source="EFO:1000288", source="MONDO:Redundant", source="NCIT:C5327"} ! head and neck neoplasm +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: disease_has_location UBERON:0007811 ! craniocervical region +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333944 +property_value: exactMatch NCIT:C5327 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0006247 +name: histiocytic and dendritic cell neoplasm +def: "Rare tumors that affect the hematopoietic and lymphoid tissues. The cells of origin are the histiocytes and accessory cells. They can occur at any age and show no significant variations in geographical distribution. This category includes the histiocytic sarcoma, Langerhans cell histiocytosis, Langerhans cell sarcoma, interdigitading dendritic cell sarcoma/tumor, follicular dendritic cell sarcoma/tumor, and dendritic cell sarcoma, not otherwise specified. (WHO, 2001)" [NCIT:C9294] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98287"} +synonym: "histiocytic and dendritic cell" RELATED [DOID:5621] +synonym: "histiocytic and dendritic cell cancer" RELATED [DOID:5621] +synonym: "histiocytic and dendritic cell neoplasm" EXACT [NCIT:C9294] +synonym: "histiocytic and Dendritic cell neoplasms" EXACT [NCIT:C9294] +synonym: "histiocytic and dendritic cell tumor" RELATED [Orphanet:98287] +synonym: "histiocytic and Dendritic cell tumors" EXACT [NCIT:C9294] +xref: DOID:5621 {source="MONDO:equivalentTo"} +xref: EFO:1000297 {source="MONDO:equivalentTo"} +xref: NCIT:C9294 {source="EFO:1000297", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:98287 {source="MONDO:equivalentTo"} +xref: UMLS:C1334030 {source="MONDO:equivalentTo", source="NCIT:C9294"} +xref: UMLS:CN206982 {source="MONDO:equivalentTo"} +is_a: MONDO:0015757 {source="Orphanet:98287"} ! lymphoid hemopathy +is_a: MONDO:0044881 {source="NCIT:C9294"} ! hematopoietic and lymphoid cell neoplasm +property_value: exactMatch DOID:5621 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334030 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206982 +property_value: exactMatch NCIT:C9294 +property_value: exactMatch Orphanet:98287 + +[Term] +id: MONDO:0006250 +name: ileal neuroendocrine tumor G1 +alt_id: MONDO:0021536 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the ileum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C4935] +synonym: "carcinoid tumor of ileum" EXACT [NCIT:C4935] +synonym: "carcinoid tumor of the ileum" EXACT [NCIT:C4935] +synonym: "grade 1 neuroendocrine neoplasm of ileum" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "ileal carcinoid tumor" EXACT [NCIT:C4935] +synonym: "ileal NET G1" EXACT [NCIT:C4935] +synonym: "ileal neuroendocrine tumor G1" EXACT [NCIT:C4935] +synonym: "ileum carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "ileum carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "ileum NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "ileum neuroendocrine neoplasm G1" EXACT [] +synonym: "ileum neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000300 {source="MONDO:equivalentTo"} +xref: ICD9:209.03 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4935 {source="EFO:1000300", source="MONDO:equivalentTo"} +xref: SCTID:425318003 {source="MONDO:equivalentTo"} +xref: UMLS:C0745216 {source="MONDO:equivalentTo", source="NCIT:C4935"} +is_a: MONDO:0000540 {source="MONDO:Redundant", source="NCIT:C4935"} ! small intestinal neuroendocrine tumor G1 +is_a: MONDO:0006155 ! colon neuroendocrine tumor G1 +is_a: MONDO:0015065 {source="MONDO:Redundant", source="NCIT:C4935"} ! ileal neuroendocrine tumor, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002116 ! ileum +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://identifiers.org/snomedct/425318003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0745216 +property_value: exactMatch NCIT:C4935 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006256 +name: invasive breast carcinoma +def: "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women." [NCIT:C9245] +synonym: "BRCA" RELATED ABBREVIATION [ONCOTREE:BRCA] +synonym: "infiltrating breast cancer" EXACT [NCIT:C9245] +synonym: "infiltrating breast carcinoma" EXACT [NCIT:C9245] +synonym: "infiltrating carcinoma of breast" EXACT [NCIT:C9245] +synonym: "infiltrating carcinoma of the breast" EXACT [NCIT:C9245] +synonym: "invasive breast cancer" EXACT [NCIT:C9245] +synonym: "invasive breast carcinoma" EXACT [NCIT:C9245] +synonym: "invasive carcinoma of breast" EXACT [NCIT:C9245] +synonym: "invasive carcinoma of the breast" EXACT [NCIT:C9245] +synonym: "invasive mammary carcinoma" EXACT [NCIT:C9245] +xref: EFO:1000307 {source="MONDO:equivalentTo"} +xref: NCIT:C9245 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:1000307"} +xref: ONCOTREE:BRCA {source="MONDO:equivalentTo"} +xref: SCTID:713609000 {source="MONDO:equivalentTo"} +xref: UMLS:C0853879 {source="NCIT:C9245", source="MONDO:equivalentTo"} +is_a: MONDO:0004989 {source="EFO:1000307", source="MONDO:Redundant", source="NCIT:C9245"} ! breast carcinoma +is_a: MONDO:0040677 ! invasive carcinoma +intersection_of: MONDO:0004989 ! breast carcinoma +intersection_of: has_modifier PATO:0002129 ! neoplastic, invasive +property_value: exactMatch http://identifiers.org/snomedct/713609000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0853879 +property_value: exactMatch NCIT:C9245 + +[Term] +id: MONDO:0006257 +name: jejunal neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the jejunum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C6429] +synonym: "carcinoid tumor of jejunum" EXACT [NCIT:C6429] +synonym: "carcinoid tumor of the jejunum" EXACT [NCIT:C6429] +synonym: "grade 1 neuroendocrine neoplasm of jejunum" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "jejunal carcinoid tumor" EXACT [NCIT:C6429] +synonym: "jejunal NET G1" EXACT [NCIT:C6429] +synonym: "jejunum carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "jejunum carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "jejunum NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "jejunum neuroendocrine neoplasm G1" EXACT [] +synonym: "jejunum neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: EFO:1000308 {source="MONDO:equivalentTo"} +xref: NCIT:C6429 {source="MONDO:equivalentTo", source="EFO:1000308"} +xref: UMLS:C1334296 {source="MONDO:equivalentTo", source="NCIT:C6429"} +is_a: MONDO:0000540 {source="MONDO:Redundant", source="NCIT:C6429"} ! small intestinal neuroendocrine tumor G1 +is_a: MONDO:0006155 ! colon neuroendocrine tumor G1 +is_a: MONDO:0015064 ! jejunal neuroendocrine tumor, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002115 ! jejunum +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334296 +property_value: exactMatch NCIT:C6429 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0006260 +name: kidney medullary carcinoma +alt_id: MONDO:0017888 +def: "A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis." [NCIT:C7572] +subset: ordo_disease {source="Orphanet:319319"} +synonym: "carcinoma of renal medulla" EXACT [MONDO:patterns/carcinoma] +synonym: "kidney medullary carcinoma" EXACT [NCIT:C7572] +synonym: "renal medulla carcinoma" EXACT [] +synonym: "renal medullary carcinoma" EXACT [NCIT:C7572] +xref: EFO:1000314 {source="MONDO:equivalentTo"} +xref: GARD:0013175 {source="MONDO:equivalentTo"} +xref: ICD10CM:C64 {source="Orphanet:319319/ntbt", source="Orphanet:319319"} +xref: MedDRA:10064886 {source="Orphanet:319319", source="Orphanet:319319/e"} +xref: NCIT:C7572 {source="MONDO:equivalentTo", source="EFO:1000314"} +xref: ONCOTREE:MRC {source="MONDO:equivalentTo"} +xref: Orphanet:319319 {source="MONDO:equivalentTo"} +xref: UMLS:CN203938 {source="MONDO:equivalentTo"} +is_a: MONDO:0005086 {source="ONCOTREE:MRC/inferred", source="Orphanet:319319"} ! renal cell carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000362 ! renal medulla +relationship: disease_has_location UBERON:0000362 ! renal medulla +property_value: closeMatch http://identifiers.org/meddra/10064886 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203938 +property_value: exactMatch NCIT:C7572 +property_value: exactMatch Orphanet:319319 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C64 + +[Term] +id: MONDO:0006278 +name: lung papilloma +def: "A benign papillary neoplasm that arises endobronchially. It is classified as squamous cell, glandular, or mixed squamous cell and glandular papilloma. Patients usually present with signs and symptoms of bronchial obstruction." [NCIT:C8295] +synonym: "lung papilloma" EXACT [MONDO:patterns/location, NCIT:C8295] +synonym: "papilloma of respiratory tract" EXACT [NCIT:C8295] +synonym: "papilloma of the respiratory tract" EXACT [NCIT:C8295] +synonym: "respiratory tract papilloma" EXACT [NCIT:C8295] +xref: EFO:1000335 {source="MONDO:equivalentTo"} +xref: NCIT:C8295 {source="MONDO:equivalentTo", source="EFO:1000335", source="MONDO:exact-label-match"} +xref: UMLS:C0281373 {source="MONDO:equivalentTo"} +is_a: MONDO:0002363 {source="MONDO:Redundant", source="NCIT:C8295"} ! papilloma +is_a: MONDO:0002732 ! lung benign neoplasm +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0281373 +property_value: exactMatch NCIT:C8295 + +[Term] +id: MONDO:0006284 +name: major salivary gland carcinoma +def: "A carcinoma that arises from the parotid gland, submandibular gland, or sublingual gland." [NCIT:C5907] +synonym: "carcinoma of Major salivary gland" EXACT [NCIT:C5907] +synonym: "carcinoma of major salivary gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the major salivary gland" EXACT [NCIT:C5907] +synonym: "major salivary gland cancer" BROAD [NCIT:C5907] +synonym: "major salivary gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C5907] +xref: EFO:1000344 {source="MONDO:equivalentTo"} +xref: NCIT:C5907 {source="EFO:1000344", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1334549 {source="NCIT:C5907", source="MONDO:equivalentTo"} +is_a: MONDO:0000521 {source="MONDO:Redundant", source="NCIT:C5907"} ! salivary gland carcinoma +is_a: MONDO:0044743 ! major salivary gland cancer +intersection_of: MONDO:0004993 {source="NCIT:C5907"} ! carcinoma +intersection_of: disease_has_location UBERON:0001829 {source="NCIT:C5907"} ! major salivary gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334549 +property_value: exactMatch NCIT:C5907 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006290 +name: malignant germ cell tumor +def: "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma." [NCIT:C4925] +subset: gard_rare +synonym: "cancer of germ cell" EXACT [MONDO:patterns/cancer] +synonym: "germ cell cancer" EXACT [MONDO:patterns/location] +synonym: "germ cell tumor, malignant" EXACT [MONDO:patterns/malignant] +synonym: "malignant germ cell neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4925] +synonym: "malignant germ cell tumor" EXACT [NCIT:C4925] +synonym: "malignant neoplasm of germ cell" EXACT [MONDO:patterns/cancer, NCIT:C4925] +synonym: "malignant neoplasm of the germ cell" EXACT [NCIT:C4925] +synonym: "malignant tumor of germ cell" EXACT [NCIT:C4925] +synonym: "malignant tumor of the germ cell" EXACT [NCIT:C4925] +xref: EFO:1000352 {source="MONDO:equivalentTo"} +xref: GARD:0003360 {source="MONDO:equivalentTo"} +xref: NCIT:C4925 {source="EFO:1000352", source="MONDO:equivalentTo"} +xref: SCTID:145831000119103 {source="MONDO:equivalentTo"} +xref: UMLS:C4048549 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 ! cancer +is_a: MONDO:0005040 {source="EFO:1000352", source="MONDO:Redundant", source="NCIT:C4925"} ! germ cell tumor +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch http://identifiers.org/snomedct/145831000119103 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4048549 +property_value: exactMatch NCIT:C4925 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0006291 +name: malignant jugulotympanic paraganglioma +def: "A jugulotympanic paraganglioma that metastasizes to other anatomic sites." [NCIT:C4623] +synonym: "cancer of jugular body" EXACT [MONDO:patterns/cancer] +synonym: "jugular body cancer" EXACT [MONDO:patterns/location] +synonym: "malignant glomus jugulare neoplasm" EXACT [NCIT:C4623] +synonym: "malignant glomus jugulare tumor" EXACT [NCIT:C4623] +synonym: "malignant jugular body neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant jugulotympanic paraganglioma" EXACT [NCIT:C4623] +synonym: "malignant neoplasm of glomus jugulare" EXACT [NCIT:C4623] +synonym: "malignant neoplasm of jugular body" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the glomus jugulare" EXACT [NCIT:C4623] +synonym: "malignant tumor of glomus jugulare" EXACT [NCIT:C4623] +synonym: "malignant tumor of the glomus jugulare" EXACT [NCIT:C4623] +xref: EFO:1000353 {source="MONDO:equivalentTo"} +xref: NCIT:C4623 {source="EFO:1000353", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C0347856 {source="MONDO:equivalentTo", source="NCIT:C4623"} +is_a: MONDO:0002095 ! vascular cancer +is_a: MONDO:0002132 ! skull cancer +is_a: MONDO:0002714 ! central nervous system cancer +is_a: MONDO:0021064 {source="NCIT:C4623"} ! jugulotympanic paraganglioma +is_a: MONDO:0021069 {source="MONDO:Redundant", source="NCIT:C4623/inferred"} ! malignant endocrine neoplasm +is_a: MONDO:0021089 ! peripheral nervous system cancer +is_a: MONDO:0021310 ! malignant tumor of neck +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0034972 ! jugular body +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347856 +property_value: exactMatch NCIT:C4623 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006294 +name: pleural cancer +def: "A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site." [NCIT:C3547] +synonym: "cancer of pleura" EXACT [MONDO:patterns/cancer, NCIT:C3547] +synonym: "cancer of the pleura" EXACT [NCIT:C3547] +synonym: "malignant neoplasm of pleura" EXACT [MONDO:patterns/cancer, NCIT:C3547] +synonym: "malignant neoplasm of the pleura" EXACT [NCIT:C3547] +synonym: "malignant pleura neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant pleural neoplasm" EXACT [NCIT:C3547] +synonym: "malignant pleural tumor" EXACT [NCIT:C3547] +synonym: "malignant tumor of pleura" EXACT [NCIT:C3547] +synonym: "malignant tumor of the pleura" EXACT [NCIT:C3547] +synonym: "neoplasm of pleura" BROAD [DOID:5158] +synonym: "pleura cancer" EXACT [MONDO:patterns/location] +synonym: "pleural cancer" EXACT [MONDO:0003309, NCIT:C3547] +synonym: "pleural tumor" BROAD [DOID:5158, NCIT:C3332] +xref: DOID:5158 {source="MONDO:equivalentTo"} +xref: EFO:1000362 {source="MONDO:equivalentTo"} +xref: ICD10CM:C38.4 {source="DOID:5158", source="MONDO:equivalentTo"} +xref: ICD9:163 {source="DOID:5158"} +xref: ICD9:163.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:163.9 {source="DOID:5158", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3547 {source="EFO:1000362", source="DOID:5158", source="MONDO:equivalentTo"} +xref: SCTID:363433009 {source="DOID:5158", source="MONDO:equivalentTo"} +xref: UMLS:C0153494 {source="DOID:5158", source="MONDO:equivalentTo", source="NCIT:C3547"} +is_a: MONDO:0000376 {source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0003274 {source="NCIT:C3547"} ! thoracic cancer +is_a: MONDO:0021065 {source="MONDO:Redundant", source="NCIT:C3547"} ! pleural neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000977 ! pleura +property_value: exactMatch DOID:5158 +property_value: exactMatch http://identifiers.org/snomedct/363433009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153494 +property_value: exactMatch https://icd.codes/icd10cm/C38.4 +property_value: exactMatch NCIT:C3547 +property_value: excluded_subClassOf MONDO:0002176 {source="DOID:5158"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006295 +name: malignant urinary system neoplasm +def: "A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas." [NCIT:C9297] +synonym: "cancer of renal system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of renal system" EXACT [MONDO:patterns/cancer] +synonym: "malignant renal system neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant urinary system neoplasm" EXACT [NCIT:C9297] +synonym: "malignant urinary tract neoplasm" EXACT [NCIT:C9297] +synonym: "renal system cancer" EXACT [MONDO:patterns/location] +synonym: "urinary system cancer" EXACT [MONDO:0002827] +xref: DOID:3996 {source="MONDO:equivalentTo"} +xref: EFO:1000363 {source="MONDO:equivalentTo"} +xref: ICD10CM:C64-C68 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:189.9 {source="DOID:3996"} +xref: NCIT:C9297 {source="EFO:1000363", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: SCTID:448233000 {source="MONDO:equivalentTo", source="DOID:3996"} +is_a: MONDO:0004992 {source="DOID:3996", source="DOID:3996/inferred", source="MONDO:Redundant"} ! cancer +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C9297"} ! urinary system neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch DOID:3996 +property_value: exactMatch http://identifiers.org/snomedct/448233000 +property_value: exactMatch https://icd.codes/icd10cm/C64-C68 +property_value: exactMatch NCIT:C9297 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006298 +name: mediastinal malignant germ cell tumor +def: "An extragonadal malignant germ cell tumor that arises from the mediastinum. This category includes seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, mixed germ cell tumors, and immature malignant teratoma." [NCIT:C6446] +synonym: "malignant germ cell neoplasm of mediastinum" RELATED [NCIT:C6446] +synonym: "malignant germ cell neoplasm of the mediastinum" RELATED [NCIT:C6446] +synonym: "malignant germ cell tumor of mediastinum" RELATED [NCIT:C6446] +synonym: "malignant germ cell tumor of the mediastinum" RELATED [NCIT:C6446] +synonym: "malignant mediastinal germ cell neoplasm" RELATED [NCIT:C6446] +synonym: "malignant mediastinal germ cell tumor" EXACT [] +synonym: "mediastinal germ cell tumor, malignant" EXACT [MONDO:patterns/malignant] +synonym: "mediastinal malignant germ cell tumor" EXACT [NCIT:C6446] +synonym: "thymic malignant germ cell tumor" EXACT [NCIT:C6446] +xref: EFO:1000366 {source="MONDO:equivalentTo"} +xref: NCIT:C6446 {source="EFO:1000366", source="MONDO:equivalentTo", source="NCIT:C6446"} +xref: SCTID:713293002 {source="MONDO:equivalentTo"} +xref: UMLS:C1334597 {source="MONDO:equivalentTo", source="NCIT:C6446"} +is_a: MONDO:0003113 ! extragonadal germ cell cancer +is_a: MONDO:0005843 {source="MONDO:Redundant", source="NCIT:C6446"} ! mediastinal cancer +is_a: MONDO:0021067 {source="MONDO:Redundant", source="NCIT:C6446"} ! mediastinal germ cell tumor +intersection_of: MONDO:0021067 ! mediastinal germ cell tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch http://identifiers.org/snomedct/713293002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334597 +property_value: exactMatch NCIT:C6446 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0006303 +name: middle ear squamous cell carcinoma +def: "A rare squamous cell carcinoma that arises from the middle ear." [NCIT:C6086] +synonym: "epidermoid carcinoma of middle Ear" EXACT [NCIT:C6086] +synonym: "epidermoid carcinoma of the middle Ear" EXACT [NCIT:C6086] +synonym: "epidermoid carcinoma of the middle ear" EXACT [DOID:5526, NCIT:C6086] +synonym: "middle Ear epidermoid carcinoma" EXACT [NCIT:C6086] +synonym: "middle ear squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C6086] +synonym: "squamous cell carcinoma of middle Ear" EXACT [NCIT:C6086] +synonym: "squamous cell carcinoma of middle ear" RELATED [DOID:5526] +synonym: "squamous cell carcinoma of the middle Ear" EXACT [NCIT:C6086] +xref: DOID:5526 {source="MONDO:equivalentTo"} +xref: EFO:1000378 {source="MONDO:equivalentTo"} +xref: NCIT:C6086 {source="DOID:5526", source="MONDO:equivalentTo", source="EFO:1000378", source="MONDO:exact-label-match"} +xref: UMLS:C1334762 {source="NCIT:C6086", source="DOID:5526", source="MONDO:equivalentTo"} +is_a: MONDO:0003190 {source="DOID:5526", source="MONDO:Redundant", source="NCIT:C6086"} ! middle ear carcinoma +is_a: MONDO:0010150 {source="EFO:1000378", source="MONDO:Redundant", source="NCIT:C6086/inferred"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch DOID:5526 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334762 +property_value: exactMatch NCIT:C6086 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006304 +name: minor salivary gland adenocarcinoma +def: "An adenocarcinoma that arises from the minor salivary glands." [NCIT:C5948] +synonym: "adenocarcinoma of minor salivary gland" EXACT [NCIT:C5948] +synonym: "adenocarcinoma of the minor salivary gland" EXACT [NCIT:C5948] +xref: EFO:1000379 {source="MONDO:equivalentTo"} +xref: NCIT:C5948 {source="MONDO:equivalentTo", source="EFO:1000379", source="MONDO:exact-label-match"} +xref: UMLS:C1334768 {source="NCIT:C5948", source="MONDO:equivalentTo"} +is_a: MONDO:0004970 {source="EFO:1000379", source="MONDO:Redundant", source="NCIT:C5948/inferred"} ! adenocarcinoma +is_a: MONDO:0045069 ! minor salivary gland carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001830 ! minor salivary gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334768 +property_value: exactMatch NCIT:C5948 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006322 +name: non-neoplastic bile duct disorder +def: "A non-neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts. Representative examples include cholangitis and biliary atresia." [NCIT:C35774] +synonym: "non-neoplastic bile duct disorder" EXACT [NCIT:C35774] +xref: EFO:1000400 {source="MONDO:equivalentTo"} +xref: NCIT:C35774 {source="MONDO:equivalentTo", source="EFO:1000400", source="MONDO:exact-label-match"} +xref: UMLS:C3275160 {source="MONDO:equivalentTo", source="NCIT:C35774"} +is_a: MONDO:0002887 {source="NCIT:C35774"} ! bile duct disorder +is_a: MONDO:0005151 {source="EFO:1000400"} ! endocrine system disorder +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3275160 +property_value: exactMatch NCIT:C35774 + +[Term] +id: MONDO:0006327 +name: ocular sebaceous carcinoma +def: "Ocular sebaceous carcinoma is a rare condition and accounts for 1% to 5.5% of eyelid malignancies and is the third most common eyelid malignancy after basal cell and squamous cell carcinoma. It usually affects elderly women, has a high rate of local recurrence, and a tendency to regional and distant metastases." [EFO:1000405] +synonym: "eye sebaceous carcinoma" EXACT [NCIT:C43340] +synonym: "ocular sebaceous carcinoma" EXACT [NCIT:C43340] +xref: EFO:1000405 {source="MONDO:equivalentTo"} +xref: NCIT:C43340 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:1000405"} +xref: UMLS:C1709308 {source="MONDO:equivalentTo", source="NCIT:C43340"} +is_a: MONDO:0002466 {source="NCIT:C43340"} ! eye carcinoma +is_a: MONDO:0006962 {source="NCIT:C43340"} ! sebaceous adenocarcinoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1709308 +property_value: exactMatch NCIT:C43340 + +[Term] +id: MONDO:0006335 +name: ovarian endometrioid adenocarcinoma +def: "An endometrioid adenocarcinoma arising from the ovary. It comprises 10% to 25% of all primary ovarian carcinomas. Grossly, endometrioid carcinoma may present as a cystic or solid mass. Microscopically, the tumor greatly resembles the appearance of the ordinary type of endometrial adenocarcinoma. As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma." [NCIT:C7979] +subset: ordo_disease {source="Orphanet:454723"} +synonym: "endometrioid adenocarcinoma of ovary" EXACT [NCIT:C7979] +synonym: "endometrioid adenocarcinoma of the ovary" EXACT [NCIT:C7979] +synonym: "endometrioid cancer of ovary" EXACT [NCIT:C7979] +synonym: "endometrioid cancer of the ovary" EXACT [NCIT:C7979] +synonym: "endometrioid carcinoma of ovary" EXACT [DOID:5828, NCIT:C7979] +synonym: "endometrioid carcinoma of the ovary" EXACT [NCIT:C7979] +synonym: "endometrioid carcinoma ovary" EXACT [DOID:5828] +synonym: "endometrioid ovarian cancer" RELATED [ONCOTREE:EOV] +synonym: "endometrioid ovary carcinoma" EXACT [MONDO:0003662] +synonym: "endometrium adenocarcinoma of ovary" EXACT [MONDO:design_pattern] +synonym: "ovarian endometrioid adenocarcinoma" EXACT [NCIT:C7979] +synonym: "ovarian endometrioid cancer" EXACT [NCIT:C7979] +synonym: "ovarian endometrioid carcinoma" EXACT [DOID:5828, NCIT:C7979] +synonym: "ovary endometrium adenocarcinoma" EXACT [MONDO:patterns/location] +xref: DOID:5828 {source="MONDO:equivalentTo"} +xref: EFO:1000416 {source="MONDO:equivalentTo"} +xref: ICD10CM:C56 {source="Orphanet:454723", source="Orphanet:454723/ntbt"} +xref: NCIT:C7979 {source="MONDO:equivalentTo", source="EFO:1000416", source="DOID:5828"} +xref: ONCOTREE:EOV {source="MONDO:equivalentTo"} +xref: Orphanet:454723 {source="MONDO:equivalentTo"} +xref: SCTID:254852002 {source="MONDO:equivalentTo", source="DOID:5828"} +xref: UMLS:C0346163 {source="MONDO:equivalentTo", source="Orphanet:454723", source="DOID:5828", source="NCIT:C7979"} +is_a: MONDO:0002752 {source="DOID:5828", source="EFO:1000416", source="MONDO:Redundant", source="NCIT:C7979"} ! ovarian adenocarcinoma +is_a: MONDO:0003812 {source="NCIT:C7979"} ! ovarian endometrial cancer +is_a: MONDO:0005026 {source="NCIT:C7979"} ! endometrioid adenocarcinoma +is_a: MONDO:0005461 {source="EFO:1000416", source="MONDO:Redundant"} ! endometrium adenocarcinoma +intersection_of: MONDO:0005461 ! endometrium adenocarcinoma +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:5828 +property_value: exactMatch http://identifiers.org/snomedct/254852002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346163 +property_value: exactMatch NCIT:C7979 +property_value: exactMatch Orphanet:454723 +property_value: narrowMatch https://icd.codes/icd10cm/C56 + +[Term] +id: MONDO:0006343 +name: ovarian transitional cell carcinoma +def: "A carcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. There is no morphologic evidence of a benign or borderline Brenner tumor component present." [NCIT:C5240] +synonym: "malignant ovarian transitional cell neoplasm" EXACT [DOID:4000] +synonym: "ovarian transitional cell cancer" EXACT [DOID:4000, NCIT:C5240] +synonym: "ovarian transitional cell carcinoma" EXACT [NCIT:C5240] +synonym: "ovarian transitional cell neoplasm" RELATED [DOID:4000] +synonym: "ovary transitional cell carcinoma" EXACT [MONDO:0002830, MONDO:patterns/location] +synonym: "transitional cell carcinoma of ovary" EXACT [DOID:4000, NCIT:C5240] +synonym: "transitional cell carcinoma of the ovary" EXACT [NCIT:C5240] +xref: DOID:4000 {source="MONDO:equivalentTo"} +xref: EFO:1000435 {source="MONDO:equivalentTo"} +xref: NCIT:C5240 {source="MONDO:equivalentTo", source="EFO:1000435", source="DOID:4000"} +xref: UMLS:C1335184 {source="NCIT:C5240", source="MONDO:equivalentTo", source="DOID:4000"} +is_a: MONDO:0005140 {source="EFO:1000435", source="MONDO:Redundant", source="NCIT:C5240"} ! ovarian carcinoma +is_a: MONDO:0006474 {source="DOID:4000", source="MONDO:Redundant", source="NCIT:C5240"} ! transitional cell carcinoma +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:4000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335184 +property_value: exactMatch NCIT:C5240 + +[Term] +id: MONDO:0006346 +name: pancreatic acinar cell carcinoma +def: "An adenocarcinoma arising from the pancreas. It is characterized by the presence of relatively uniform malignant cells which form acinar patterns. It usually occurs during adulthood. Signs and symptoms include abdominal pain, weight loss, nausea, and diarrhea. It may metastasize to regional lymph nodes and the liver. A minority of patients develop lipase hypersecretion syndrome. This syndrome may be seen in patients with liver metastases and it is characterized by excessive secretion of lipase in the serum, polyarthralgia, and subcutaneous fat necrosis." [NCIT:C7977] +subset: ordo_disease {source="Orphanet:424046"} +synonym: "acinar cell adenocarcinoma of pancreas" EXACT [NCIT:C7977] +synonym: "acinar cell adenocarcinoma of the pancreas" EXACT [NCIT:C7977] +synonym: "acinar cell carcinoma of pancreas" EXACT [MONDO:0018522, NCIT:C7977] +synonym: "acinar cell carcinoma of the pancreas" EXACT [NCIT:C7977] +synonym: "carcinoma of pancreatic acinar cell" EXACT [MONDO:patterns/carcinoma] +synonym: "PAAC" RELATED ABBREVIATION [ONCOTREE:PAAC] +synonym: "pancreas acinar cell adenocarcinoma" EXACT [NCIT:C7977] +synonym: "pancreatic acinar cell adenocarcinoma" EXACT [MONDO:0003623, NCIT:C7977] +synonym: "Pancreatic acinar cell cancer" EXACT [NCIT:C7977] +synonym: "pancreatic acinar cell carcinoma" EXACT [DOID:5742, MONDO:patterns/location, NCIT:C7977, Orphanet:424046] +xref: DOID:5742 {source="MONDO:equivalentTo"} +xref: EFO:1000439 {source="MONDO:equivalentTo"} +xref: NCIT:C7977 {source="DOID:5742", source="MONDO:equivalentTo", source="EFO:1000439"} +xref: ONCOTREE:PAAC {source="MONDO:equivalentTo"} +xref: Orphanet:424046 {source="MONDO:equivalentTo"} +xref: UMLS:C0279661 {source="DOID:5742", source="MONDO:equivalentTo", source="NCIT:C7977", source="Orphanet:424046"} +is_a: MONDO:0004965 {source="DOID:5742", source="EFO:1000439", source="MONDO:Redundant", source="NCIT:C7977"} ! acinar cell carcinoma +is_a: MONDO:0006047 {source="DOID:5742", source="MONDO:Redundant", source="NCIT:C7977"} ! pancreatic adenocarcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0002064 ! pancreatic acinar cell +relationship: disease_has_location CL:0002064 ! pancreatic acinar cell +relationship: has_modifier MONDO:0021136 {source="MONDO:0016314"} ! rare +property_value: exactMatch DOID:5742 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279661 +property_value: exactMatch NCIT:C7977 +property_value: exactMatch Orphanet:424046 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006354 +name: parathyroid hyperplasia +def: "A hyperplasia that involves the parathyroid gland." [MONDO:patterns/location] +synonym: "hyperplasia of parathyroid" EXACT [NCIT:C3989] +synonym: "hyperplasia of the parathyroid" EXACT [NCIT:C3989] +synonym: "parathyroid gland hyperplasia" EXACT [MONDO:patterns/location] +synonym: "parathyroid hyperplasia" EXACT [MONDO:ambiguous, NCIT:C3989] +synonym: "parathyroid hyperplasia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: EFO:1000457 {source="MONDO:equivalentTo"} +xref: HP:0008208 {source="MONDO:otherHierarchy"} +xref: NCIT:C3989 {source="MONDO:equivalentTo", source="EFO:1000457"} +xref: SCTID:9092004 {source="MONDO:equivalentTo"} +xref: UMLS:C0271844 {source="MONDO:equivalentTo", source="NCIT:C3989"} +is_a: MONDO:0001223 {source="MONDO:Redundant"} ! parathyroid gland disorder +is_a: MONDO:0005043 {source="EFO:1000457", source="MONDO:Redundant", source="NCIT:C3989"} ! hyperplasia +intersection_of: MONDO:0005043 ! hyperplasia +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +property_value: exactMatch http://identifiers.org/snomedct/9092004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271844 +property_value: exactMatch NCIT:C3989 +property_value: IAO:0000589 "parathyroid hyperplasia (disease)" xsd:string + +[Term] +id: MONDO:0006355 +name: parotid gland acinic cell carcinoma +def: "An adenocarcinoma with serous acinar cell differentiation that arises from the parotid gland. Patients usually present with a slow growing mass in the parotid area." [NCIT:C5933] +synonym: "acinic cell carcinoma of parotid" RELATED [NCIT:C5933] +synonym: "acinic cell carcinoma of parotid gland" RELATED [NCIT:C5933] +synonym: "acinic cell carcinoma of the parotid" RELATED [NCIT:C5933] +synonym: "acinic cell carcinoma of the parotid gland" RELATED [NCIT:C5933] +synonym: "parotid acinic cell carcinoma" RELATED [NCIT:C5933] +synonym: "parotid gland acinar cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "parotid gland acinic cell carcinoma" EXACT [NCIT:C5933] +xref: EFO:1000458 {source="MONDO:equivalentTo"} +xref: NCIT:C5933 {source="MONDO:equivalentTo", source="EFO:1000458", source="NCIT:C5933"} +xref: UMLS:C1335353 {source="MONDO:equivalentTo", source="NCIT:C5933"} +is_a: MONDO:0004965 {source="EFO:1000458", source="MONDO:Redundant", source="NCIT:C5933/inferred"} ! acinar cell carcinoma +is_a: MONDO:0021331 {source="MONDO:Redundant", source="NCIT:C5933/inferred"} ! carcinoma of parotid gland +intersection_of: MONDO:0004965 ! acinar cell carcinoma +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335353 +property_value: exactMatch NCIT:C5933 + +[Term] +id: MONDO:0006358 +name: parotid gland squamous cell carcinoma +def: "An invasive squamous cell carcinoma that arises from the parotid gland. It usually affects elderly patients and presents as a rapidly enlarging tumor mass, often associated with pain." [NCIT:C5942] +synonym: "parotid gland squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "parotid squamous cell carcinoma" EXACT [NCIT:C5942] +synonym: "squamous cell carcinoma of parotid" EXACT [NCIT:C5942] +synonym: "squamous cell carcinoma of parotid gland" EXACT [NCIT:C5942] +synonym: "squamous cell carcinoma of the parotid" EXACT [NCIT:C5942] +synonym: "squamous cell carcinoma of the parotid gland" EXACT [NCIT:C5942] +xref: EFO:1000463 {source="MONDO:equivalentTo"} +xref: NCIT:C5942 {source="EFO:1000463", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1335367 {source="MONDO:equivalentTo", source="NCIT:C5942"} +is_a: MONDO:0021331 {source="MONDO:Redundant", source="NCIT:C5942"} ! carcinoma of parotid gland +is_a: MONDO:0044740 ! salivary gland squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335367 +property_value: exactMatch NCIT:C5942 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006360 +name: penile carcinoma +def: "A carcinoma that arises from epithelial cells of the penis" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of penis" BROAD [NCIT:C9061] +synonym: "cancer of the penis" BROAD [NCIT:C9061] +synonym: "cancer penis" BROAD [GARD:0009366] +synonym: "carcinoma of penis" EXACT [MONDO:patterns/carcinoma, NCIT:C9061] +synonym: "carcinoma of the penis" EXACT [NCIT:C9061] +synonym: "penile cancer" BROAD [NCIT:C9061] +synonym: "penile cancer, adult" NARROW [GARD:0009366] +synonym: "penile carcinoma" EXACT [DOID:3449, NCIT:C9061] +synonym: "penis carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:3449 {source="EFO:1000465", source="MONDO:equivalentTo"} +xref: EFO:1000465 {source="MONDO:equivalentTo"} +xref: GARD:0009366 {source="MONDO:equivalentTo"} +xref: NCIT:C9061 {source="EFO:1000465", source="MONDO:equivalentTo", source="DOID:3449"} +xref: SCTID:372106005 {source="MONDO:equivalentTo", source="DOID:3449"} +is_a: MONDO:0001325 {source="DOID:3449", source="MONDO:Redundant", source="NCIT:C9061"} ! penile cancer +is_a: MONDO:0004993 {source="DOID:3449", source="EFO:1000465", source="MONDO:Redundant", source="NCIT:C9061"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch DOID:3449 +property_value: exactMatch http://identifiers.org/snomedct/372106005 +property_value: exactMatch NCIT:C9061 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006402 +name: salivary gland basal cell adenocarcinoma +def: "A rare adenocarcinoma of the major and minor salivary glands, originating from basaloid, myoepithelial and ductal cells. While morphologically resembling basal cell carcinomas, it is a distinct entity. The tumor is not encapsulated, may invade locally, and less frequently may metastasize. It usually occurs in older patients." [NCIT:C3678] +synonym: "basal cell adenocarcinoma" EXACT [NCIT:C3678] +synonym: "basal cell adenocarcinoma of salivary gland" EXACT [NCIT:C3678] +synonym: "basal cell adenocarcinoma of the salivary gland" EXACT [NCIT:C3678] +synonym: "saliva-secreting gland skin basal cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "salivary gland basal cell adenocarcinoma" EXACT [NCIT:C3678] +synonym: "skin basal cell carcinoma of saliva-secreting gland" EXACT [MONDO:design_pattern] +xref: EFO:1000515 {source="MONDO:equivalentTo"} +xref: ICDO:8147/3 {source="NCIT:C3678"} +xref: NCIT:C3678 {source="MONDO:equivalentTo", source="EFO:1000515"} +is_a: MONDO:0004970 {source="EFO:1000515", source="NCIT:C3678/inferred"} ! adenocarcinoma +is_a: MONDO:0005341 {source="EFO:1000515", source="MONDO:Redundant"} ! skin basal cell carcinoma +is_a: MONDO:0044740 ! salivary gland squamous cell carcinoma +intersection_of: MONDO:0005341 ! skin basal cell carcinoma +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +relationship: disease_has_location CL:0000646 {source="EFO:0000784"} ! basal cell +property_value: exactMatch NCIT:C3678 + +[Term] +id: MONDO:0006420 +name: small intestinal mucosa-associated lymphoid tissue lymphoma +def: "A mucosa-associated lymphoid tissue lymphoma (MALT) that arises from the small intestine. The morphologic characteristics are similar to those seen in gastric MALT lymphomas, with the exception of the lymphoepithelial lesions that are less prominent in the small intestine." [NCIT:C5635] +synonym: "MALT lymphoma of small bowel" EXACT [NCIT:C5635] +synonym: "MALT lymphoma of small intestine" EXACT [NCIT:C5635] +synonym: "MALT lymphoma of the small bowel" EXACT [NCIT:C5635] +synonym: "MALT lymphoma of the small intestine" EXACT [NCIT:C5635] +synonym: "MALToma of small bowel" EXACT [NCIT:C5635] +synonym: "MALToma of small intestine" EXACT [NCIT:C5635] +synonym: "MALToma of the small bowel" EXACT [NCIT:C5635] +synonym: "MALToma of the small intestine" EXACT [NCIT:C5635] +synonym: "mucosa-associated lymphoid tissue lymphoma of small bowel" EXACT [NCIT:C5635] +synonym: "mucosa-associated lymphoid tissue lymphoma of small intestine" EXACT [NCIT:C5635] +synonym: "mucosa-associated lymphoid tissue lymphoma of the small bowel" EXACT [NCIT:C5635] +synonym: "mucosa-associated lymphoid tissue lymphoma of the small intestine" EXACT [NCIT:C5635] +synonym: "small bowel MALT lymphoma" EXACT [NCIT:C5635] +synonym: "small bowel MALToma" EXACT [NCIT:C5635] +synonym: "small bowel mucosa-associated lymphoid tissue lymphoma" EXACT [NCIT:C5635] +synonym: "small intestinal mucosa-associated lymphoid tissue lymphoma" EXACT [NCIT:C5635] +synonym: "small intestine MALT lymphoma" EXACT [MONDO:patterns/location, NCIT:C5635] +synonym: "small intestine MALToma" EXACT [NCIT:C5635] +synonym: "small intestine mucosa-associated lymphoid tissue lymphoma" EXACT [NCIT:C5635] +xref: EFO:1000537 {source="MONDO:equivalentTo"} +xref: NCIT:C5635 {source="MONDO:equivalentTo", source="MONDO:exact-label-match", source="EFO:1000537"} +xref: UMLS:C1336004 {source="MONDO:equivalentTo", source="NCIT:C5635"} +is_a: MONDO:0001852 ! small intestine lymphoma +is_a: MONDO:0007650 {source="MONDO:Redundant", source="NCIT:C5635"} ! MALT lymphoma +is_a: MONDO:0017128 ! inherited digestive tract tumor +intersection_of: MONDO:0007650 ! MALT lymphoma +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336004 +property_value: exactMatch NCIT:C5635 + +[Term] +id: MONDO:0006447 +name: testicular non-seminomatous germ cell tumor +def: "A testicular germ cell tumor characterized by the absence of a seminomatous component. It includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, and mixed forms." [NCIT:C9313] +subset: ordo_disease {source="Orphanet:363494"} +synonym: "non-dysgerminomatous germ cell tumor of testis" EXACT [Orphanet:363494] +synonym: "non-seminomatous germ cell tumor of testis" EXACT [MONDO:0018195] +synonym: "testicular germ cell tumor non-seminomatous" EXACT [MONDO:0002873, NCIT:C9313] +synonym: "testicular non seminomatous germ cell tumor" EXACT [Orphanet:363494] +synonym: "testicular non-dysgerminomatous germ cell tumor" EXACT [Orphanet:363494] +synonym: "testicular non-seminomatous germ cell tumor" EXACT [NCIT:C9313] +xref: DOID:4086 {source="MONDO:equivalentTo"} +xref: EFO:1000570 {source="MONDO:equivalentTo"} +xref: ICD10CM:C62.1 {source="Orphanet:363494", source="Orphanet:363494/ntbt"} +xref: ICDO:9065/3 {source="NCIT:C9313"} +xref: NCIT:C9313 {source="EFO:1000570", source="MONDO:equivalentTo"} +xref: OMIM:273300 {source="Orphanet:363494", source="Orphanet:363494/ntbt"} +xref: Orphanet:363494 {source="MONDO:equivalentTo"} +xref: UMLS:C1336724 {source="NCIT:C9313", source="MONDO:equivalentTo", source="DOID:4086"} +xref: UMLS:CN204702 {source="MONDO:equivalentTo"} +is_a: MONDO:0010108 {source="DOID:4086", source="NCIT:C9313", source="Orphanet:363494"} ! testicular germ cell tumor +property_value: exactMatch DOID:4086 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336724 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204702 +property_value: exactMatch NCIT:C9313 +property_value: exactMatch Orphanet:363494 +property_value: narrowMatch https://icd.codes/icd10cm/C62.1 + +[Term] +id: MONDO:0006451 +name: thymic carcinoma +def: "Thymic carcinoma (TC) is a type of thymic epithelial neoplasm characterized by a high malignant potential." [Orphanet:99868] +subset: ordo_disease {source="Orphanet:99868"} +synonym: "carcinoma of thymus" EXACT [MONDO:patterns/carcinoma] +synonym: "malignant thymoma" EXACT [DOID:3284, NCIT:C7612, Orphanet:99868] +synonym: "THYC" RELATED ABBREVIATION [ONCOTREE:THYC] +synonym: "thymic carcinoma" EXACT [DOID:3284, NCIT:C7569] +synonym: "thymic carcinoma (excluding well differentiated thymic carcinoma)" EXACT [NCIT:C7569] +synonym: "thymic carcinoma excluding well differentiated thymic carcinoma" EXACT [NCIT:C7569] +synonym: "thymoma type C" EXACT DEPRECATED [NCIT:C7569] +synonym: "thymoma, malignant" EXACT [DOID:3284] +synonym: "thymoma, malignant (morphologic abnormality)" EXACT [DOID:3284] +synonym: "thymoma, type C" EXACT [DOID:4554] +synonym: "thymoma, type C (morphologic abnormality)" EXACT [DOID:4554] +synonym: "thymus carcinoma" EXACT [MONDO:patterns/location] +synonym: "type C thymoma" EXACT DEPRECATED [MONDO:0003048, NCIT:C7569] +xref: DOID:3284 {source="MONDO:equivalentTo"} +xref: DOID:4554 {source="MONDO:equivalentTo"} +xref: EFO:1000576 {source="MONDO:equivalentTo"} +xref: GARD:0011952 {source="MONDO:equivalentTo"} +xref: ICD10CM:C37 {source="Orphanet:99868", source="Orphanet:99868/ntbt"} +xref: ICDO:8586/3 {source="NCIT:C7569"} +xref: MedDRA:10061031 {source="Orphanet:99868", source="Orphanet:99868/e"} +xref: NCIT:C7569 {source="DOID:4554", source="MONDO:equivalentTo", source="EFO:1000576"} +xref: ONCOTREE:THYC {source="MONDO:equivalentTo"} +xref: Orphanet:99868 {source="MONDO:equivalentTo"} +xref: SCTID:444374006 {source="DOID:4554", source="MONDO:equivalentTo"} +xref: UMLS:C0205969 {source="MONDO:equivalentTo", source="Orphanet:99868", source="NCIT:C7569", source="Orphanet:99868/e", source="DOID:3284"} +xref: UMLS:C1322286 {source="DOID:4554", source="MONDO:equivalentTo", source="Orphanet:99868", source="Orphanet:99868/e"} +xref: UMLS:CN207411 {source="MONDO:equivalentTo"} +is_a: MONDO:0002586 {source="DOID:3284", source="DOID:4554/inferred", source="MONDO:Redundant", source="NCIT:C7569"} ! thymus cancer +is_a: MONDO:0004993 {source="EFO:1000576", source="MONDO:Redundant"} ! carcinoma +is_a: MONDO:0018079 {source="MONDO:Redundant", source="NCIT:C7569", source="ONCOTREE:THYC", source="Orphanet:99868"} ! thymic epithelial neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002370 ! thymus +relationship: disease_arises_from_structure CL:0002293 {source="NCIT:C7569"} ! epithelial cell of thymus +property_value: closeMatch http://identifiers.org/meddra/10061031 +property_value: exactMatch DOID:3284 +property_value: exactMatch DOID:4554 +property_value: exactMatch http://identifiers.org/snomedct/444374006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0205969 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1322286 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207411 +property_value: exactMatch NCIT:C7569 +property_value: exactMatch Orphanet:99868 +property_value: excluded_subClassOf MONDO:0006456 {source="DOID:4554"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C37 + +[Term] +id: MONDO:0006467 +name: thyroid gland squamous cell carcinoma +def: "A rapidly growing primary carcinoma of the thyroid gland composed of malignant squamous cells. The clinical course is usually aggressive." [NCIT:C46008] +synonym: "squamous cell thyroid gland carcinoma" EXACT [NCIT:C46008] +synonym: "thyroid gland squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C46008] +xref: EFO:1000594 {source="MONDO:equivalentTo"} +xref: NCIT:C46008 {source="EFO:1000594", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: UMLS:C1710177 {source="MONDO:equivalentTo", source="NCIT:C46008"} +is_a: MONDO:0005096 {source="EFO:1000594", source="MONDO:Redundant", source="NCIT:C46008"} ! squamous cell carcinoma +is_a: MONDO:0015075 {source="MONDO:Redundant", source="NCIT:C46008"} ! thyroid gland carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1710177 +property_value: exactMatch NCIT:C46008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006470 +name: tonsillar squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal lining of the tonsil and tends to metastasize early to the lymph nodes. It predominantly affects middle aged and elderly patients who have a history of alcohol and tobacco use. Patients may present with tonsillar swelling, sore throat, pain radiating to the ipsilateral ear, or a neck mass." [NCIT:P378] +synonym: "palatine tonsil squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "scc of the tonsil" EXACT [NCIT:C8183] +synonym: "scc of tonsil" EXACT [NCIT:C8183] +synonym: "squamous cell carcinoma of the tonsil" EXACT [NCIT:C8183] +synonym: "squamous cell carcinoma of tonsil" EXACT [NCIT:C8183] +synonym: "tonsil scc" EXACT [NCIT:C8183] +synonym: "tonsillar scc" EXACT [NCIT:C8183] +xref: EFO:1000597 {source="MONDO:equivalentTo"} +xref: NCIT:C8183 {source="EFO:1000597", source="MONDO:equivalentTo"} +xref: UMLS:C0280317 {source="MONDO:equivalentTo", source="NCIT:C8183"} +is_a: MONDO:0000535 ! tonsil squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002373 ! palatine tonsil +relationship: disease_has_location UBERON:0002373 ! palatine tonsil +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280317 +property_value: exactMatch NCIT:C8183 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006474 +name: transitional cell carcinoma +def: "A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries." [NCIT:P378] +subset: gard_rare {source="GARD:0007794"} +synonym: "carcinoma of transitional epithelial cell" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of urothelial cell" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, urothelial, malignant" EXACT [NCIT:C2930] +synonym: "transitional carcinoma" EXACT [DOID:2671, NCIT:C2930] +synonym: "transitional cell carcinoma" EXACT [NCIT:C2930] +synonym: "transitional cell neoplasm" BROAD [DOID:2671] +synonym: "transitional cell tumor" BROAD [DOID:2671, NCIT:C6783] +synonym: "transitional epithelial cell carcinoma" EXACT [] +synonym: "urothelial cell carcinoma" EXACT [DOID:2671, MONDO:patterns/location] +xref: DOID:2671 {source="MONDO:equivalentTo"} +xref: EFO:1000601 {source="MONDO:equivalentTo"} +xref: GARD:0007794 {source="MONDO:equivalentTo"} +xref: ICDO:8120/3 {source="NCIT:C2930"} +xref: MESH:D002295 {source="DOID:2671", source="MONDO:equivalentTo"} +xref: NCIT:C2930 {source="DOID:2671", source="MONDO:equivalentTo", source="EFO:1000601"} +xref: UMLS:C0007138 {source="DOID:2671", source="MONDO:equivalentTo", source="NCIT:C2930"} +is_a: MONDO:0004993 {source="DOID:2671", source="EFO:1000601", source="MESH:D002295", source="MONDO:Redundant", source="NCIT:C2930"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0000244 ! transitional epithelial cell +relationship: disease_has_location CL:0000244 ! transitional epithelial cell +property_value: exactMatch DOID:2671 +property_value: exactMatch http://identifiers.org/mesh/D002295 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007138 +property_value: exactMatch NCIT:C2930 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7794/transitional-cell-carcinoma xsd:anyURI {source="GARD:0007794"} + +[Term] +id: MONDO:0006481 +name: ureter carcinoma +def: "A carcinoma that arises from epithelial cells of the ureter." [https://orcid.org/0000-0002-6601-2165] +synonym: "carcinoma of the ureter" EXACT [NCIT:C8993] +synonym: "carcinoma of ureter" EXACT [MONDO:patterns/carcinoma, NCIT:C8993] +synonym: "ureter cancer" BROAD [NCIT:C8993] +synonym: "ureter carcinoma" EXACT [MONDO:patterns/location, NCIT:C8993] +synonym: "ureteral carcinoma" EXACT [DOID:4939, NCIT:C8993] +xref: DOID:4939 {source="MONDO:equivalentTo"} +xref: EFO:1000609 {source="MONDO:equivalentTo"} +xref: NCIT:C8993 {source="EFO:1000609", source="MONDO:equivalentTo", source="DOID:4939"} +xref: SCTID:448864006 {source="MONDO:equivalentTo"} +xref: UMLS:C0600079 {source="NCIT:C8993", source="MONDO:equivalentTo", source="DOID:4939"} +is_a: MONDO:0004993 {source="DOID:4939", source="EFO:1000609", source="MONDO:Redundant", source="NCIT:C8993"} ! carcinoma +is_a: MONDO:0008627 {source="DOID:4939", source="MONDO:Redundant", source="NCIT:C8993"} ! ureter cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:4939 +property_value: exactMatch http://identifiers.org/snomedct/448864006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0600079 +property_value: exactMatch NCIT:C8993 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006490 +name: vaginal squamous cell carcinoma +def: "A squamous cell carcinoma arising from the vagina. Human papillomavirus infection is associated with the development of vaginal intraepithelial neoplasia and invasive squamous cell carcinoma. Signs and symptoms include painless bleeding, postcoital bleeding, and urinary tract symptoms. Morphologically it resembles squamous cell carcinomas in other anatomic sites. Radiation therapy is the preferred treatment for most cases. The prognosis is related to the stage of the disease." [NCIT:P378] +synonym: "carcinoma of vagina squamous cell" EXACT [MONDO:patterns/carcinoma] +synonym: "epidermoid carcinoma of the vagina" EXACT [NCIT:C7736] +synonym: "epidermoid carcinoma of vagina" EXACT [NCIT:C7736] +synonym: "epidermoid cell carcinoma of the vagina" EXACT [NCIT:C7736] +synonym: "epidermoid cell carcinoma of vagina" EXACT [NCIT:C7736] +synonym: "squamous cell carcinoma of the vagina" EXACT [NCIT:C7736] +synonym: "squamous cell carcinoma of the vulva/vagina" RELATED [ONCOTREE:VSC] +synonym: "squamous cell carcinoma of vagina" EXACT [NCIT:C7736] +synonym: "vagina epidermoid carcinoma" EXACT [NCIT:C7736] +synonym: "vagina epidermoid cell carcinoma" EXACT [NCIT:C7736] +synonym: "vagina squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C7736] +synonym: "vaginal epidermoid carcinoma" EXACT [NCIT:C7736] +synonym: "vaginal epidermoid cell carcinoma" EXACT [NCIT:C7736] +synonym: "vaginal squamous cell cancer" EXACT [NCIT:C7736] +synonym: "vaginal squamous cell cancer, NOS" EXACT [NCIT:C7736] +synonym: "vaginal squamous cell carcinoma" EXACT [NCIT:C7736] +xref: EFO:1000620 {source="MONDO:equivalentTo"} +xref: NCIT:C7736 {source="MONDO:equivalentTo", source="EFO:1000620"} +xref: ONCOTREE:VSC {source="MONDO:equivalentTo"} +xref: SCTID:105121000119102 {source="MONDO:equivalentTo"} +xref: UMLS:C0238518 {source="MONDO:equivalentTo", source="NCIT:C7736"} +is_a: MONDO:0001806 {source="MONDO:Redundant", source="NCIT:C7736"} ! vaginal squamous tumor +is_a: MONDO:0005096 {source="EFO:1000620", source="MONDO:Redundant", source="NCIT:C7736"} ! squamous cell carcinoma +is_a: MONDO:0015867 {source="MONDO:Redundant", source="NCIT:C7736"} ! vaginal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch http://identifiers.org/snomedct/105121000119102 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238518 +property_value: exactMatch NCIT:C7736 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0006504 +name: acquired metabolic disease +def: "An instance of metabolic disease that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +synonym: "acquired metabolic disease" EXACT [MONDO:patterns/acquired] +xref: DOID:0060158 {source="EFO:1000639", source="MONDO:equivalentTo"} +xref: EFO:1000639 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="DOID:0060158", source="EFO:1000639", source="MONDO:Entailed", source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch DOID:0060158 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml + +[Term] +id: MONDO:0006505 +name: basal ganglia cerebrovascular disorder +def: "A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (basal ganglia), such as infarction; hemorrhage; or ischemia in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (dyskinesias) and muscle weakness (hemiparesis)." [MESH:D020144] +synonym: "cerebrovascular disorder of collection of basal ganglia" EXACT [MONDO:design_pattern] +synonym: "collection of basal ganglia cerebrovascular disorder" EXACT [MONDO:patterns/location] +xref: DOID:10991 {source="MONDO:equivalentTo", source="EFO:1000640"} +xref: EFO:1000640 {source="MONDO:equivalentTo"} +xref: MESH:D020144 {source="MONDO:equivalentTo", source="DOID:10991"} +xref: UMLS:C0751739 {source="MONDO:equivalentTo", source="DOID:10991"} +is_a: MONDO:0003996 {source="DOID:10991", source="MESH:D020144", source="MONDO:Entailed", source="MONDO:Redundant"} ! basal ganglia disorder +is_a: MONDO:0011057 {source="DOID:10991", source="EFO:1000640", source="MESH:D020144", source="MONDO:Entailed", source="MONDO:Redundant"} ! cerebrovascular disorder +intersection_of: MONDO:0011057 ! cerebrovascular disorder +intersection_of: disease_has_location UBERON:0010011 ! collection of basal ganglia +property_value: exactMatch DOID:10991 +property_value: exactMatch http://identifiers.org/mesh/D020144 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751739 + +[Term] +id: MONDO:0006510 +name: renal tubular transport disease +def: "Genetic defects in the selective or non-selective transport functions of the kidney tubules." [MESH:D015499] +synonym: "disorder of renal absorption" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "inborn renal tubular transport disorder" EXACT [DOID:447] +synonym: "kidney tubular transport, inborn error" RELATED [MESH:D015499] +synonym: "kidney tubular transport, inborn errors" RELATED [MESH:D015499] +synonym: "renal absorption disease" EXACT [MONDO:design_pattern] +synonym: "renal tubular transport errors" RELATED [MESH:D015499] +synonym: "renal tubular transport, inborn error" RELATED [MESH:D015499] +xref: DOID:447 {source="MONDO:equivalentTo", source="EFO:1000647"} +xref: EFO:1000647 {source="MONDO:equivalentTo"} +xref: MESH:D015499 {source="DOID:447", source="MONDO:equivalentTo"} +xref: UMLS:C0035091 {source="DOID:447", source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="DOID:447", source="EFO:1000647", source="MESH:D015499", source="MONDO:Redundant", source="MONDO:indirect"} ! kidney disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0070293 ! renal absorption +relationship: disease_has_basis_in_disruption_of GO:0070293 ! renal absorption +relationship: disease_has_basis_in_dysfunction_of UBERON:0009773 ! renal tubule +property_value: exactMatch DOID:447 +property_value: exactMatch http://identifiers.org/mesh/D015499 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0035091 +property_value: excluded_subClassOf MONDO:0019052 {source="MESH:D015499"} +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0006515 +name: acute pancreatitis +def: "An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs." [NCIT:P378] +synonym: "acute necrotizing pancreatitis" EXACT [DOID:2913] +synonym: "acute pancreatitis (disorder) [ambiguous]" EXACT [DOID:2913] +synonym: "pancreatitis necrotizing" EXACT [DOID:2913, MTH:NOCODE] +synonym: "pancreatitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:2913 {source="MONDO:equivalentTo"} +xref: EFO:1000652 {source="MONDO:equivalentTo"} +xref: HP:0001735 {source="EFO:1000652", source="MONDO:otherHierarchy"} +xref: ICD9:577.0 {source="DOID:2913"} +xref: MESH:D019283 {source="MONDO:equivalentTo"} +xref: NCIT:C95437 {source="MONDO:equivalentTo", source="DOID:2913"} +xref: SCTID:7881005 {source="MONDO:equivalentTo"} +xref: UMLS:C0001339 {source="NCIT:C95437", source="MONDO:equivalentTo", source="DOID:2913"} +xref: UMLS:C0267941 {source="MONDO:equivalentTo"} +xref: Wikipedia:Acute_pancreatitis {source="EFO:1000652"} +is_a: MONDO:0004982 {source="DOID:2913", source="EFO:1000652", source="MESH:D019283", source="MONDO:Redundant", source="NCIT:C95437"} ! pancreatitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0004982 ! pancreatitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch DOID:2913 +property_value: exactMatch http://identifiers.org/mesh/D019283 +property_value: exactMatch http://identifiers.org/snomedct/7881005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001339 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267941 +property_value: exactMatch NCIT:C95437 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0006517 +name: childhood malignant neoplasm +def: "A malignant tumor that occurs in children. Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor)." [NCIT:C4005] +synonym: "childhood cancer" EXACT [NCIT:C4005] +synonym: "childhood malignant neoplasm" EXACT [NCIT:C4005] +synonym: "childhood neoplasm, malignant" EXACT [MONDO:patterns/malignant] +synonym: "malignant childhood neoplasm" EXACT [NCIT:C4005] +synonym: "malignant childhood tumor" EXACT [NCIT:C4005] +synonym: "malignant neoplasm" NARROW [NCIT:C4005] +synonym: "malignant pediatric neoplasm" EXACT [NCIT:C4005] +synonym: "malignant pediatric tumor" EXACT [NCIT:C4005] +synonym: "pediatric cancer" EXACT [NCIT:C4005] +xref: EFO:1000654 {source="MONDO:equivalentTo"} +xref: NCIT:C4005 {source="MONDO:equivalentTo"} +xref: UMLS:C0278704 {source="MONDO:equivalentTo", source="NCIT:C4005"} +is_a: MONDO:0004992 {source="EFO:1000654", source="MONDO:Redundant", source="NCIT:C4005"} ! cancer +is_a: MONDO:0021079 {source="MONDO:Redundant", source="NCIT:C4005"} ! childhood neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278704 +property_value: exactMatch NCIT:C4005 + +[Term] +id: MONDO:0006519 +name: rectal cancer +def: "A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C7418] +synonym: "cancer of rectum" EXACT [DOID:1993, MONDO:patterns/cancer] +synonym: "carcinoma of rectum" BROAD [DOID:1993] +synonym: "carcinoma of the rectum" BROAD [DOID:1993, NCIT:C9382] +synonym: "malignant neoplasm of rectum" EXACT [DOID:1993, ICD9CM:154.1, MONDO:patterns/cancer, NCIT:C7418] +synonym: "malignant neoplasm of the rectum" EXACT [NCIT:C7418] +synonym: "malignant rectal neoplasm" EXACT [NCIT:C7418] +synonym: "malignant rectal tumor" EXACT [DOID:1993, NCIT:C7418] +synonym: "malignant rectum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant rectum tumor" EXACT [DOID:1993] +synonym: "malignant tumor of rectum" EXACT [NCIT:C7418] +synonym: "malignant tumor of the rectum" EXACT [NCIT:C7418] +synonym: "rectal cancer" EXACT [DOID:1993] +synonym: "rectum cancer" EXACT [MONDO:patterns/location] +xref: DOID:1993 {source="MONDO:equivalentTo", source="EFO:1000657"} +xref: EFO:1000657 {source="MONDO:equivalentTo"} +xref: ICD9:154.1 {source="DOID:1993", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7418 {source="DOID:1993", source="MONDO:equivalentTo"} +xref: SCTID:363351006 {source="DOID:1993", source="MONDO:equivalentTo"} +is_a: MONDO:0002165 {source="MONDO:Redundant", source="NCIT:C7418"} ! rectal neoplasm +is_a: MONDO:0005575 {source="DOID:1993", source="DOID:1993/inferred", source="EFO:1000657", source="MONDO:Redundant", source="NCIT:C7418"} ! colorectal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch DOID:1993 +property_value: exactMatch http://identifiers.org/snomedct/363351006 +property_value: exactMatch NCIT:C7418 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006552 +name: folliculitis +def: "Inflammation of the hair follicles. Causes include excessive perspiration, skin infections, and skin wounds." [NCIT:P378] +synonym: "dermatitis of hair follicle" EXACT [MONDO:design_pattern] +synonym: "hair follicle dermatitis" EXACT [MONDO:patterns/location] +xref: DOID:4409 {source="MONDO:equivalentTo", source="EFO:1000702"} +xref: EFO:1000702 {source="MONDO:equivalentTo"} +xref: ICD9:704.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005499 {source="MONDO:equivalentTo", source="DOID:4409"} +xref: NCIT:C94408 {source="MONDO:equivalentTo", source="DOID:4409"} +xref: SCTID:13600006 {source="MONDO:equivalentTo", source="DOID:4409"} +xref: Wikipedia:Folliculitis {source="EFO:1000702"} +is_a: MONDO:0002406 ! dermatitis +is_a: MONDO:0002917 {source="DOID:4409", source="MESH:D005499", source="MONDO:Redundant", source="NCIT:C94408/inferred"} ! disorder of pilosebaceous unit +intersection_of: MONDO:0002406 ! dermatitis +intersection_of: disease_has_inflammation_site UBERON:0002073 ! hair follicle +relationship: disease_has_inflammation_site UBERON:0002073 ! hair follicle +property_value: exactMatch DOID:4409 +property_value: exactMatch http://identifiers.org/mesh/D005499 +property_value: exactMatch http://identifiers.org/snomedct/13600006 +property_value: exactMatch NCIT:C94408 + +[Term] +id: MONDO:0006591 +name: panniculitis +def: "Inflammation of the subcutaneous adipose tissue." [NCIT:P378] +synonym: "inflammation of subcutaneous adipose tissue" EXACT [] +synonym: "Subcutaneous adipose tissue" EXACT [NCIT:C33645] +synonym: "subcutaneous adipose tissue inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "Subcutaneous tissue" EXACT [NCIT:C33645] +synonym: "subcutis" EXACT [NCIT:C33645] +xref: DOID:1526 {source="MONDO:equivalentTo", source="EFO:1000746"} +xref: EFO:1000746 {source="MONDO:equivalentTo"} +xref: ICD9:729.3 {source="DOID:1526"} +xref: ICD9:729.30 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:1526"} +xref: ICD9:729.39 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D015434 {source="MONDO:equivalentTo", source="DOID:1526"} +xref: NCIT:C112112 {source="MONDO:otherHierarchy", source="DOID:1526"} +xref: NCIT:C33645 {source="MONDO:equivalentTo"} +xref: SCTID:22125009 {source="MONDO:equivalentTo", source="DOID:1526"} +xref: UMLS:C0030326 {source="MONDO:equivalentTo", source="DOID:1526"} +xref: Wikipedia:Panniculitis {source="EFO:1000746"} +is_a: MONDO:0002051 ! integumentary system disorder +is_a: MONDO:0003900 {source="MESH:D015434", source="MONDO:Redundant"} ! connective tissue disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002190 ! subcutaneous adipose tissue +relationship: disease_has_inflammation_site UBERON:0002190 ! subcutaneous adipose tissue +property_value: exactMatch DOID:1526 +property_value: exactMatch http://identifiers.org/mesh/D015434 +property_value: exactMatch http://identifiers.org/snomedct/22125009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030326 +property_value: exactMatch NCIT:C33645 +property_value: excluded_subClassOf MONDO:0005546 {source="DOID:1526"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: relatedMatch NCIT:C112112 + +[Term] +id: MONDO:0006607 +name: sebaceous gland disorder +def: "A disease involving the sebaceous gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of sebaceous gland" EXACT [MONDO:patterns/location_top] +synonym: "disease of sebaceous glands" RELATED [] +synonym: "disease or disorder of sebaceous gland" EXACT [] +synonym: "disorder of sebaceous gland" EXACT [MONDO:patterns/location_top] +synonym: "sebaceous gland disease" EXACT [MONDO:patterns/location] +synonym: "sebaceous gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:9098 {source="MONDO:equivalentTo", source="EFO:1000763"} +xref: EFO:1000763 {source="MONDO:equivalentTo"} +xref: ICD9:706.1 {source="DOID:9098"} +xref: MESH:D012625 {source="MONDO:equivalentTo"} +xref: SCTID:3441005 {source="MONDO:equivalentTo"} +xref: UMLS:C0036502 {source="MONDO:equivalentTo"} +is_a: MONDO:0002917 ! disorder of pilosebaceous unit +is_a: MONDO:0005093 {source="DOID:9098", source="EFO:1000763", source="MESH:D012625"} ! skin disorder +is_a: MONDO:0024481 ! skin appendage disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001821 ! sebaceous gland +relationship: disease_has_location UBERON:0001821 ! sebaceous gland +property_value: exactMatch DOID:9098 +property_value: exactMatch http://identifiers.org/mesh/D012625 +property_value: exactMatch http://identifiers.org/snomedct/3441005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036502 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0006615 +name: sweat gland disorder +def: "A disease involving the sweat gland." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of sweat gland" EXACT [MONDO:patterns/location_top] +synonym: "disease of sweat glands" RELATED [] +synonym: "disease or disorder of sweat gland" EXACT [] +synonym: "disorder of sweat gland" EXACT [MONDO:patterns/location_top] +synonym: "disorder of sweat glands" RELATED [] +synonym: "sweat gland disease" EXACT [MONDO:patterns/location] +synonym: "sweat gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:1383 {source="MONDO:equivalentTo", source="EFO:1000772"} +xref: EFO:1000772 {source="MONDO:equivalentTo"} +xref: ICD9:705 {source="DOID:1383"} +xref: ICD9:705.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:705.9 {source="DOID:1383", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D013543 {source="DOID:1383", source="MONDO:equivalentTo"} +xref: SCTID:88232005 {source="DOID:1383", source="MONDO:equivalentTo"} +xref: UMLS:C0038986 {source="DOID:1383", source="MONDO:equivalentTo"} +is_a: MONDO:0005093 {source="DOID:1383", source="EFO:1000772", source="MESH:D013543"} ! skin disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001820 ! sweat gland +relationship: disease_has_location UBERON:0001820 ! sweat gland +property_value: exactMatch DOID:1383 +property_value: exactMatch http://identifiers.org/mesh/D013543 +property_value: exactMatch http://identifiers.org/snomedct/88232005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038986 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0006626 +name: diabetic neuropathy +def: "A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction." [NCIT:P378] +xref: DOID:9743 {source="MONDO:equivalentTo"} +xref: EFO:1000783 {source="MONDO:equivalentTo"} +xref: ICD9:250.6 {source="DOID:9743"} +xref: MESH:D003929 {source="DOID:9743", source="MONDO:equivalentTo", source="EFO:1000783"} +xref: NCIT:C26748 {source="DOID:9743", source="MONDO:equivalentTo"} +xref: SCTID:230572002 {source="DOID:9743", source="MONDO:equivalentTo"} +xref: UMLS:C0011882 {source="DOID:9743", source="MONDO:equivalentTo", source="NCIT:C26748"} +is_a: MONDO:0005244 {source="DOID:9743", source="EFO:1000783", source="EFO:1000783/inferred", source="MONDO:Redundant", source="NCIT:C26748"} ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +relationship: disease_arises_from_feature MONDO:0005015 ! diabetes mellitus +property_value: exactMatch DOID:9743 +property_value: exactMatch http://identifiers.org/mesh/D003929 +property_value: exactMatch http://identifiers.org/snomedct/230572002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011882 +property_value: exactMatch NCIT:C26748 + +[Term] +id: MONDO:0006639 +name: adrenal cortex carcinoma +def: "A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival." [NCIT:C9325] +subset: ordo_disease {source="Orphanet:1501"} +synonym: "ACC" EXACT ABBREVIATION [ONCOTREE:ACC] +synonym: "adenocarcinoma, adrenocortical, malignant" EXACT [NCIT:C9325] +synonym: "adrenal cortex adenocarcinoma" EXACT [DOID:3959, NCIT:C9325, NCIT:C9326] +synonym: "adrenal cortex cancer" BROAD [NCIT:C9325] +synonym: "adrenal cortex carcinoma" EXACT [MONDO:patterns/location, NCIT:C9325] +synonym: "adrenal cortical adenocarcinoma" EXACT [DOID:3959, MONDO:0002818, NCIT:C9325] +synonym: "adrenal cortical carcinoma" EXACT [NCIT:C9325] +synonym: "adrenal cortical carcinoma (morphologic abnormality)" EXACT [DOID:3948] +synonym: "adrenal cortical tumors" BROAD [DOID:660] +synonym: "adrenocortical cancer" BROAD [NCIT:C9325] +synonym: "adrenocortical carcinoma" EXACT [MONDO:0015460, MONDO:ambiguous, NCIT:C9325] +synonym: "adrenocortical carcinoma (disease)" EXACT [MONDO:0005241] +synonym: "cancer of the adrenal cortex" BROAD [NCIT:C9325] +synonym: "carcinoma of adrenal cortex" EXACT [MONDO:patterns/carcinoma, NCIT:C9325] +synonym: "carcinoma of the adrenal cortex" EXACT [DOID:3948, NCIT:C9325] +synonym: "carcinoma, adrenocortical, malignant" EXACT [NCIT:C9325] +synonym: "cortical cell carcinoma" EXACT [NCIT:C9325] +synonym: "malignant adrenocortical tumor" BROAD [DOID:660, NCIT:C9327] +synonym: "malignant neoplasm of adrenal cortex" BROAD [DOID:660] +synonym: "malignant tumour of adrenal cortex" BROAD [DOID:660] +xref: DOID:3948 {source="MONDO:equivalentTo", source="EFO:0003093"} +xref: DOID:3959 {source="MONDO:equivalentTo"} +xref: DOID:660 {source="MONDO:equivalentTo", source="EFO:1000796"} +xref: EFO:1000796 {source="MONDO:equivalentTo"} +xref: GARD:0000558 {source="MONDO:equivalentTo"} +xref: HP:0006744 {source="MONDO:otherHierarchy"} +xref: ICDO:8370/3 {source="NCIT:C9325"} +xref: MedDRA:10001388 {source="Orphanet:1501", source="Orphanet:1501/e"} +xref: NCIT:C9325 {source="MONDO:equivalentTo", source="EFO:1000796", source="EFO:0003093", source="DOID:3948"} +xref: OMIM:202300 {source="Orphanet:1501", source="EFO:0003093", source="DOID:3948", source="Orphanet:1501/btnt"} +xref: ONCOTREE:ACC {source="MONDO:equivalentTo"} +xref: Orphanet:1501 {source="MONDO:equivalentTo"} +xref: SCTID:255035007 {source="MONDO:equivalentTo", source="DOID:3948"} +xref: UMLS:C0206686 {source="NCIT:C9325", source="MONDO:equivalentTo", source="Orphanet:1501", source="DOID:3948", source="Orphanet:1501/e"} +is_a: MONDO:0002095 ! vascular cancer +is_a: MONDO:0002814 ! adrenal carcinoma +is_a: MONDO:0005086 ! renal cell carcinoma +is_a: MONDO:0015077 {source="Orphanet:1501"} ! adrenal/paraganglial tumor +is_a: MONDO:0021312 {source="MONDO:Redundant", source="NCIT:C9325"} ! malignant tumor of adrenal cortex +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001235 ! adrenal cortex +property_value: closeMatch http://identifiers.org/meddra/10001388 +property_value: exactMatch DOID:3948 +property_value: exactMatch DOID:3959 +property_value: exactMatch DOID:660 +property_value: exactMatch http://identifiers.org/snomedct/255035007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206686 +property_value: exactMatch NCIT:C9325 +property_value: exactMatch Orphanet:1501 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_subClassOf MONDO:0018627 {source="Orphanet:1501"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006643 +name: alcoholic cardiomyopathy +def: "A dilated cardiomyopathy which is associated with consumption of large amounts of alcohol over a period of years." [NCIT:P378] +synonym: "alcohol-induced heart muscle disease" EXACT [DOID:12935] +synonym: "alcoholic cardiomyopathy" EXACT [DOID:12935, ICD9CM:425.5] +synonym: "dilated cardiomyopathy secondary to alcohol" EXACT [DOID:12935] +xref: DOID:12935 {source="MONDO:equivalentTo", source="EFO:1000801"} +xref: EFO:1000801 {source="MONDO:equivalentTo"} +xref: ICD10CM:I42.6 {source="DOID:12935", source="MONDO:equivalentTo", source="EFO:1000801"} +xref: ICD9:425.5 {source="DOID:12935", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10001616 {source="EFO:1000801"} +xref: MESH:D002310 {source="DOID:12935", source="MONDO:equivalentTo", source="EFO:1000801"} +xref: NCIT:C53653 {source="DOID:12935", source="MONDO:equivalentTo", source="EFO:1000801"} +xref: SCTID:83521008 {source="DOID:12935", source="MONDO:equivalentTo", source="EFO:1000801"} +xref: UMLS:C0007192 {source="DOID:12935", source="MONDO:equivalentTo", source="NCIT:C53653"} +is_a: MONDO:0002824 {source="DOID:12935"} ! extrinsic cardiomyopathy +is_a: MONDO:0021699 {source="MESH:D002310", source="MONDO:Entailed"} ! alcohol-induced disorders +intersection_of: MONDO:0004994 ! cardiomyopathy +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: closeMatch http://identifiers.org/meddra/10001616 +property_value: exactMatch DOID:12935 +property_value: exactMatch http://identifiers.org/mesh/D002310 +property_value: exactMatch http://identifiers.org/snomedct/83521008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007192 +property_value: exactMatch https://icd.codes/icd10cm/I42.6 +property_value: exactMatch NCIT:C53653 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0006651 +name: anterior uveitis +def: "Inflammation of the iris and anterior chamber of the eye." [NCIT:C35109] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:280886"} +synonym: "anterior uveitis" EXACT [MONDO:0017253, MONDO:ambiguous, NCIT:C35109] +synonym: "anterior uveitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "iridocyclitis" NARROW [Orphanet:280886] +xref: CSP:1114-9593 {source="DOID:1407"} +xref: DOID:1407 {source="MONDO:equivalentTo", source="EFO:1000811"} +xref: EFO:1000811 {source="MONDO:equivalentTo"} +xref: GARD:0010941 {source="MONDO:equivalentTo"} +xref: HP:0012122 {source="MONDO:otherHierarchy"} +xref: ICD10CM:H20.0 {source="Orphanet:280886/btnt", source="Orphanet:280886"} +xref: ICD10CM:H20.1 {source="Orphanet:280886/btnt", source="Orphanet:280886"} +xref: ICD10CM:H20.2 {source="Orphanet:280886/btnt", source="Orphanet:280886"} +xref: ICD10CM:H20.8 {source="Orphanet:280886/btnt", source="Orphanet:280886"} +xref: ICD10CM:H20.9 {source="Orphanet:280886/btnt", source="Orphanet:280886"} +xref: MedDRA:10002709 {source="Orphanet:280886/e", source="EFO:1000811", source="Orphanet:280886"} +xref: MESH:D014606 {source="MONDO:equivalentTo", source="DOID:1407", source="EFO:1000811"} +xref: NCIT:C35109 {source="MONDO:equivalentTo", source="DOID:1407", source="EFO:1000811", source="NCIT:C35109"} +xref: Orphanet:280886 {source="MONDO:equivalentTo"} +xref: SCTID:410692006 {source="MONDO:equivalentTo", source="DOID:1407", source="EFO:1000811"} +xref: UMLS:C0042165 {source="Orphanet:280886/e", source="MONDO:equivalentTo", source="DOID:1407", source="NCIT:C35109", source="Orphanet:280886"} +is_a: MONDO:0020283 {source="DOID:1407/inferred", source="NCIT:C35109", source="Orphanet:280886"} ! uveitis +property_value: broadMatch https://icd.codes/icd10cm/H20.0 +property_value: broadMatch https://icd.codes/icd10cm/H20.1 +property_value: broadMatch https://icd.codes/icd10cm/H20.2 +property_value: broadMatch https://icd.codes/icd10cm/H20.8 +property_value: broadMatch https://icd.codes/icd10cm/H20.9 +property_value: closeMatch http://identifiers.org/meddra/10002709 +property_value: exactMatch DOID:1407 +property_value: exactMatch http://identifiers.org/mesh/D014606 +property_value: exactMatch http://identifiers.org/snomedct/410692006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042165 +property_value: exactMatch NCIT:C35109 +property_value: exactMatch Orphanet:280886 +property_value: IAO:0000589 "anterior uveitis (disease)" xsd:string + +[Term] +id: MONDO:0006656 +name: aortitis +def: "Inflammation of the aorta. Causes include trauma, infectious disorders, and connective tissue disorders." [NCIT:P378] +synonym: "aorta inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of aorta" EXACT [] +xref: DOID:519 {source="EFO:1000816", source="MONDO:equivalentTo"} +xref: EFO:1000816 {source="MONDO:equivalentTo"} +xref: MedDRA:10002921 {source="EFO:1000816"} +xref: MESH:D001025 {source="EFO:1000816", source="MONDO:equivalentTo", source="DOID:519"} +xref: NCIT:C97085 {source="EFO:1000816", source="MONDO:equivalentTo", source="DOID:519"} +xref: SCTID:70933002 {source="EFO:1000816", source="MONDO:equivalentTo", source="DOID:519"} +xref: UMLS:C0003509 {source="NCIT:C97085", source="MONDO:equivalentTo", source="DOID:519"} +is_a: MONDO:0005561 {source="DOID:519", source="EFO:1000816", source="MESH:D001025", source="MONDO:Redundant"} ! aortic disorder +is_a: MONDO:0018882 ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000947 ! aorta +relationship: disease_has_inflammation_site UBERON:0000947 ! aorta +property_value: closeMatch http://identifiers.org/meddra/10002921 +property_value: exactMatch DOID:519 +property_value: exactMatch http://identifiers.org/mesh/D001025 +property_value: exactMatch http://identifiers.org/snomedct/70933002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003509 +property_value: exactMatch NCIT:C97085 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006662 +name: aseptic meningitis +def: "Inflammation of the membranes surrounding the brain and spinal cord without a bacterial pathogen." [NCIT:P378] +synonym: "acute aseptic meningitis" EXACT [DOID:12157] +synonym: "aseptic meningitis" EXACT [DOID:12157] +xref: DOID:12157 {source="MONDO:equivalentTo", source="EFO:1000823"} +xref: EFO:1000823 {source="MONDO:equivalentTo"} +xref: MedDRA:10003458 {source="EFO:1000823"} +xref: MESH:D008582 {source="MONDO:equivalentTo", source="DOID:12157", source="EFO:1000823"} +xref: NCIT:C118299 {source="MONDO:equivalentTo", source="DOID:12157", source="EFO:1000823"} +xref: SCTID:301770000 {source="MONDO:equivalentTo", source="DOID:12157", source="EFO:1000823"} +xref: UMLS:C0025290 {source="NCIT:C118299", source="MONDO:equivalentTo", source="DOID:12157"} +is_a: MONDO:0021108 {source="MONDO:Redundant", source="NCIT:C118299"} ! meningitis +disjoint_from: MONDO:0006670 ! bacterial meningitis +property_value: closeMatch http://identifiers.org/meddra/10003458 +property_value: exactMatch DOID:12157 +property_value: exactMatch http://identifiers.org/mesh/D008582 +property_value: exactMatch http://identifiers.org/snomedct/301770000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025290 +property_value: exactMatch NCIT:C118299 +property_value: excluded_subClassOf MONDO:0007015 {source="DOID:12157"} + +[Term] +id: MONDO:0006668 +name: bacterial conjunctivitis +def: "Inflammation of the conjunctiva caused by a variety of bacterial agents." [NCIT:P378] +synonym: "Bacteria caused conjunctival disease" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria conjunctival disease" EXACT [] +synonym: "purulent conjunctivitis" EXACT [DOID:9700] +xref: DOID:9700 {source="EFO:1000829", source="MONDO:equivalentTo"} +xref: EFO:1000829 {source="MONDO:equivalentTo"} +xref: ICD9:372.03 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10061784 {source="EFO:1000829"} +xref: MESH:D003234 {source="DOID:9700", source="EFO:1000829", source="MONDO:equivalentTo"} +xref: NCIT:C53656 {source="DOID:9700", source="EFO:1000829", source="MONDO:equivalentTo"} +xref: SCTID:243321006 {source="DOID:9700", source="MONDO:equivalentTo"} +xref: UMLS:C0009768 {source="DOID:9700", source="MONDO:equivalentTo", source="NCIT:C53656"} +is_a: MONDO:0003799 {source="DOID:9700", source="MESH:D003234", source="NCIT:C53656/inferred"} ! conjunctivitis +is_a: MONDO:0005113 {source="MESH:D003234/inferred", source="MONDO:Redundant", source="NCIT:C53656"} ! bacterial infectious disease +is_a: MONDO:0043885 ! eye infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +intersection_of: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +property_value: closeMatch http://identifiers.org/meddra/10061784 +property_value: exactMatch DOID:9700 +property_value: exactMatch http://identifiers.org/mesh/D003234 +property_value: exactMatch http://identifiers.org/snomedct/243321006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009768 +property_value: exactMatch NCIT:C53656 + +[Term] +id: MONDO:0006669 +name: bacterial endocarditis +def: "Endocarditis that is caused by an infection with a bacterial agent." [NCIT:C128359] +synonym: "Bacteria caused endocarditis (disease)" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria endocarditis (disease)" EXACT [] +synonym: "bacterial endocarditis" EXACT [MONDO:ambiguous] +synonym: "bacterial endocarditis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: EFO:1000830 {source="MONDO:equivalentTo"} +xref: HP:0006689 {source="MONDO:otherHierarchy"} +xref: MedDRA:10004019 {source="EFO:1000830"} +xref: MESH:D004697 {source="MONDO:equivalentTo", source="EFO:1000830"} +xref: NCIT:C128359 {source="MONDO:equivalentTo"} +xref: SCTID:301183007 {source="MONDO:equivalentTo", source="EFO:1000830"} +xref: UMLS:C0014121 {source="MONDO:equivalentTo", source="NCIT:C128359"} +is_a: MONDO:0000565 ! infective endocarditis +is_a: MONDO:0005113 ! bacterial infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +intersection_of: disease_has_inflammation_site UBERON:0002165 ! endocardium +property_value: closeMatch http://identifiers.org/meddra/10004019 +property_value: exactMatch http://identifiers.org/mesh/D004697 +property_value: exactMatch http://identifiers.org/snomedct/301183007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014121 +property_value: exactMatch NCIT:C128359 +property_value: IAO:0000589 "bacterial endocarditis (disease)" xsd:string + +[Term] +id: MONDO:0006670 +name: bacterial meningitis +def: "Inflammation of the membranes surrounding the brain and spinal cord due to a bacterial infection." [NCIT:P378] +subset: gard_rare {source="GARD:0005881"} +synonym: "Bacteria caused infectious meningitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria infectious meningitis" EXACT [] +synonym: "meningitis, bacterial" RELATED [GARD:0005881] +xref: DOID:9470 {source="MONDO:equivalentTo", source="EFO:1000831"} +xref: EFO:1000831 {source="MONDO:equivalentTo"} +xref: GARD:0005881 {source="MONDO:equivalentTo"} +xref: ICD9:320 {source="DOID:9470", source="EFO:1000831"} +xref: ICD9:320.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:320.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:320.9 {source="DOID:9470", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10004049 {source="EFO:1000831"} +xref: MESH:D016920 {source="DOID:9470", source="MONDO:equivalentTo", source="EFO:1000831"} +xref: NCIT:C118297 {source="DOID:9470", source="MONDO:equivalentTo", source="EFO:1000831"} +xref: SCTID:95883001 {source="DOID:9470", source="MONDO:equivalentTo", source="EFO:1000831"} +xref: UMLS:C0085437 {source="NCIT:C118297", source="DOID:9470", source="MONDO:equivalentTo"} +is_a: MONDO:0004796 {source="DOID:9470", source="EFO:1000831", source="MESH:D016920", source="MONDO:Redundant", source="NCIT:C118297"} ! infectious meningitis +is_a: MONDO:0005113 ! bacterial infectious disease +intersection_of: MONDO:0004796 ! infectious meningitis +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +property_value: closeMatch http://identifiers.org/meddra/10004049 +property_value: exactMatch DOID:9470 +property_value: exactMatch http://identifiers.org/mesh/D016920 +property_value: exactMatch http://identifiers.org/snomedct/95883001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085437 +property_value: exactMatch NCIT:C118297 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5881/bacterial-meningitis xsd:anyURI {source="GARD:0005881"} + +[Term] +id: MONDO:0006672 +name: balanitis +def: "An infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge." [NCIT:C26705] +synonym: "balanitis" EXACT [NCIT:C26705] +synonym: "glans penis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of glans penis" EXACT [] +xref: DOID:13033 {source="MONDO:equivalentTo", source="EFO:1000833"} +xref: EFO:1000833 {source="MONDO:equivalentTo"} +xref: ICD10CM:N48.1 {source="MONDO:equivalentTo", source="DOID:13033"} +xref: ICD10WHO:N48.1 {source="MONDO:equivalentTo"} +xref: MedDRA:10004073 {source="EFO:1000833"} +xref: MESH:D001446 {source="MONDO:equivalentTo", source="DOID:13033", source="EFO:1000833"} +xref: NCIT:C26705 {source="MONDO:equivalentTo", source="DOID:13033", source="EFO:1000833"} +xref: SCTID:44882003 {source="MONDO:equivalentTo", source="DOID:13033", source="EFO:1000833"} +xref: UMLS:C0004690 {source="MONDO:equivalentTo", source="DOID:13033", source="NCIT:C26705"} +is_a: MONDO:0002036 {source="DOID:13033", source="MESH:D001446", source="MONDO:Redundant", source="NCIT:C26705/inferred"} ! penile disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001299 ! glans penis +relationship: disease_has_inflammation_site UBERON:0001299 ! glans penis +property_value: closeMatch http://identifiers.org/meddra/10004073 +property_value: exactMatch DOID:13033 +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/N48.1 +property_value: exactMatch http://identifiers.org/mesh/D001446 +property_value: exactMatch http://identifiers.org/snomedct/44882003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004690 +property_value: exactMatch https://icd.codes/icd10cm/N48.1 +property_value: exactMatch NCIT:C26705 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006682 +name: brachial plexus neuritis +def: "An inflammatory process affecting the brachial plexus. It results in severe pain in the upper extremity and shoulder, upper arm weakness and loss of sensation in the upper arm." [NCIT:P378] +subset: gard_rare +synonym: "acute brachial neuritis" RELATED [GARD:0004228] +synonym: "acute brachial neuritis syndrome" RELATED [GARD:0004228] +synonym: "acute brachial radiculitis syndrome" RELATED [GARD:0004228] +synonym: "acute shoulder neuritis" RELATED [GARD:0004228] +synonym: "brachial nerve plexus neuritis" EXACT [MONDO:patterns/location] +synonym: "brachial neuritis" EXACT [DOID:3689] +synonym: "idiopathic neuralgic amyotrophy" RELATED [GARD:0004228] +synonym: "neuritis of brachial nerve plexus" EXACT [MONDO:design_pattern] +synonym: "parsonage Turner syndrome" RELATED [GARD:0004228] +synonym: "parsonage-Aldren-Turner syndrome" EXACT [DOID:3689] +xref: DOID:3689 {source="MONDO:equivalentTo", source="EFO:1000843"} +xref: EFO:1000843 {source="MONDO:equivalentTo"} +xref: GARD:0004228 {source="MONDO:equivalentTo"} +xref: ICD9:723.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10073002 {source="EFO:1000843"} +xref: MESH:D020968 {source="DOID:3689", source="MONDO:equivalentTo", source="EFO:1000843"} +xref: NCIT:C84600 {source="DOID:3689", source="MONDO:equivalentTo", source="EFO:1000843"} +xref: SCTID:26609002 {source="DOID:3689", source="MONDO:directSiblingOf"} +xref: SCTID:72893007 {source="DOID:3689", source="MONDO:equivalentTo"} +is_a: MONDO:0002122 {source="DOID:3689", source="MESH:D020968", source="MONDO:Redundant"} ! neuritis +is_a: MONDO:0006683 {source="DOID:3689", source="EFO:1000843", source="MESH:D020968", source="MONDO:Redundant"} ! brachial plexus neuropathy +intersection_of: MONDO:0002122 ! neuritis +intersection_of: disease_has_location UBERON:0001814 ! brachial nerve plexus +property_value: closeMatch http://identifiers.org/meddra/10073002 +property_value: exactMatch DOID:3689 +property_value: exactMatch http://identifiers.org/mesh/D020968 +property_value: exactMatch http://identifiers.org/snomedct/72893007 +property_value: exactMatch NCIT:C84600 + +[Term] +id: MONDO:0006683 +name: brachial plexus neuropathy +def: "A brachial plexus disorder characterized by regional paresthesia, pain and muscle weakness, and limited movement in the arm or hand." [NCIT:P378] +synonym: "brachial nerve plexus peripheral neuropathy" EXACT [MONDO:patterns/location] +synonym: "brachial plexopathy" EXACT [DOID:3690, NCIT:C27194] +synonym: "brachial plexus disorder" EXACT [DOID:3690] +synonym: "peripheral neuropathy of brachial nerve plexus" EXACT [MONDO:design_pattern] +xref: DOID:3690 {source="MONDO:equivalentTo", source="EFO:1000844"} +xref: EFO:1000844 {source="MONDO:equivalentTo"} +xref: ICD9:353.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D020516 {source="MONDO:equivalentTo", source="DOID:3690", source="EFO:1000844"} +xref: NCIT:C27194 {source="MONDO:equivalentTo", source="DOID:3690"} +xref: SCTID:3548001 {source="MONDO:equivalentTo", source="DOID:3690"} +xref: UMLS:C0700251 {source="MONDO:equivalentTo", source="DOID:3690", source="NCIT:C27194"} +is_a: MONDO:0024432 {source="MONDO:Redundant", source="NCIT:C27194"} ! nerve plexus disorder +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_location UBERON:0001814 ! brachial nerve plexus +relationship: disease_has_location UBERON:0001814 ! brachial nerve plexus +property_value: exactMatch DOID:3690 +property_value: exactMatch http://identifiers.org/mesh/D020516 +property_value: exactMatch http://identifiers.org/snomedct/3548001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0700251 +property_value: exactMatch NCIT:C27194 + +[Term] +id: MONDO:0006700 +name: choroid cancer +def: "A malignant neoplasm involving the optic choroid." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of optic choroid" EXACT [MONDO:patterns/cancer] +synonym: "choroid neoplasm" BROAD [DOID:12759] +synonym: "choroidal tumor" BROAD [DOID:12759, NCIT:C2949] +synonym: "malignant choroid neoplasm" EXACT [NCIT:C3566] +synonym: "malignant choroid tumor" EXACT [NCIT:C3566] +synonym: "malignant neoplasm of choroid" EXACT [NCIT:C3566] +synonym: "malignant neoplasm of optic choroid" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the choroid" EXACT [NCIT:C3566] +synonym: "malignant optic choroid neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of choroid" EXACT [NCIT:C3566] +synonym: "malignant tumor of the choroid" EXACT [DOID:12759, NCIT:C3566] +synonym: "optic choroid cancer" EXACT [MONDO:patterns/location] +xref: DOID:12759 {source="MONDO:equivalentTo", source="EFO:1000866"} +xref: EFO:1000866 {source="MONDO:equivalentTo"} +xref: ICD9:190.6 {source="DOID:12759", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10057405 {source="EFO:1000866"} +xref: MESH:D002830 {source="DOID:12759", source="MONDO:equivalentTo", source="EFO:1000866"} +xref: NCIT:C3566 {source="DOID:12759", source="MONDO:equivalentTo"} +xref: SCTID:363466008 {source="DOID:12759", source="MONDO:equivalentTo"} +is_a: MONDO:0002095 ! vascular cancer +is_a: MONDO:0002659 {source="DOID:12759", source="MONDO:Redundant", source="NCIT:C3566"} ! uveal cancer +is_a: MONDO:0021258 {source="MONDO:Redundant", source="NCIT:C3566"} ! choroid neoplasm +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001776 ! optic choroid +property_value: closeMatch http://identifiers.org/meddra/10057405 +property_value: exactMatch DOID:12759 +property_value: exactMatch http://identifiers.org/mesh/D002830 +property_value: exactMatch http://identifiers.org/snomedct/363466008 +property_value: exactMatch NCIT:C3566 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006704 +name: CNS demyelinating autoimmune disease +def: "Conditions characterized by loss or dysfunction of myelin (see myelin sheath) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or oligodendroglia associated autoantigens." [MESH:D020278] +xref: EFO:1000870 {source="MONDO:equivalentTo"} +xref: MESH:D020278 {source="EFO:1000870", source="MONDO:equivalentTo"} +is_a: MONDO:0007179 {source="EFO:1000870", source="MESH:D020278/inferred"} ! autoimmune disease +property_value: exactMatch http://identifiers.org/mesh/D020278 + +[Term] +id: MONDO:0006709 +name: common bile duct neoplasm +def: "Tumor or cancer of the common bile duct including the ampulla of vater and the sphincter of oddi." [MESH:D003138] +synonym: "common bile duct neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "common bile duct tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of common bile duct" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of common bile duct" EXACT [MONDO:patterns/neoplasm] +xref: DOID:4608 {source="MONDO:equivalentTo", source="EFO:1000876"} +xref: EFO:1000876 {source="MONDO:equivalentTo"} +xref: MESH:D003138 {source="MONDO:equivalentTo", source="EFO:1000876", source="DOID:4608"} +xref: SCTID:126857009 {source="MONDO:equivalentTo", source="EFO:1000876", source="DOID:4608"} +xref: UMLS:C0009442 {source="MONDO:equivalentTo", source="DOID:4608"} +is_a: MONDO:0002886 {source="MESH:D003138", source="MONDO:Redundant"} ! common bile duct disorder +is_a: MONDO:0021385 {source="MONDO:Redundant"} ! extrahepatic bile duct neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001174 ! common bile duct +property_value: exactMatch DOID:4608 +property_value: exactMatch http://identifiers.org/mesh/D003138 +property_value: exactMatch http://identifiers.org/snomedct/126857009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009442 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006715 +name: coronary stenosis +def: "Narrowing of the coronary artery lumen diameter." [NCIT:P378] +synonym: "coronary artery stenosis" EXACT [DOID:4248] +xref: DOID:4248 {source="MONDO:equivalentTo", source="EFO:1000882"} +xref: EFO:1000882 {source="MONDO:equivalentTo"} +xref: MedDRA:10011089 {source="EFO:1000882"} +xref: MESH:D023921 {source="DOID:4248", source="MONDO:equivalentTo", source="EFO:1000882"} +xref: NCIT:C80427 {source="DOID:4248", source="MONDO:otherHierarchy", source="EFO:1000882"} +xref: SCTID:233970002 {source="DOID:4248", source="MONDO:equivalentTo"} +xref: UMLS:C0242231 {source="DOID:4248", source="MONDO:equivalentTo"} +is_a: MONDO:0005010 {source="DOID:4248", source="EFO:1000882", source="EFO:1000882/inferred"} ! coronary artery disorder +property_value: closeMatch http://identifiers.org/meddra/10011089 +property_value: exactMatch DOID:4248 +property_value: exactMatch http://identifiers.org/mesh/D023921 +property_value: exactMatch http://identifiers.org/snomedct/233970002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0242231 +property_value: relatedMatch NCIT:C80427 + +[Term] +id: MONDO:0006730 +name: drug psychosis +def: "Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance." [MESH:D011605] +synonym: "drug-induced psychosis" EXACT [DOID:1742] +synonym: "drug-induced psychotic disorder" EXACT [DOID:1742, ICD9CM:292.1] +xref: DOID:1742 {source="MONDO:equivalentTo", source="EFO:1000902"} +xref: EFO:1000902 {source="MONDO:equivalentTo"} +xref: ICD9:292.1 {source="DOID:1742"} +xref: MedDRA:10045855 {source="EFO:1000902"} +xref: MESH:D011605 {source="DOID:1742", source="MONDO:equivalentTo", source="EFO:1000902"} +xref: SCTID:191483003 {source="DOID:1742", source="MONDO:equivalentTo", source="EFO:1000902"} +is_a: MONDO:0001423 {source="DOID:1742", source="MONDO:Redundant"} ! drug-induced mental disorder +is_a: MONDO:0004630 {source="https://orcid.org/0000-0001-5208-3432"} ! substance-induced psychosis +intersection_of: MONDO:0005485 ! psychotic disorder +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: closeMatch http://identifiers.org/meddra/10045855 +property_value: exactMatch DOID:1742 +property_value: exactMatch http://identifiers.org/mesh/D011605 +property_value: exactMatch http://identifiers.org/snomedct/191483003 + +[Term] +id: MONDO:0006734 +name: benign duodenal neoplasm +alt_id: MONDO:0021504 +def: "A non-metastasizing neoplasm arising from the wall of the duodenum." [NCIT:C4775] +synonym: "benign duodenal neoplasm" EXACT [NCIT:C4775] +synonym: "benign duodenal tumor" EXACT [NCIT:C4775] +synonym: "benign neoplasm of duodenum" EXACT [NCIT:C4775] +synonym: "benign neoplasm of the duodenum" EXACT [NCIT:C4775] +synonym: "benign tumor of duodenum" EXACT [NCIT:C4775] +synonym: "benign tumor of the duodenum" EXACT [NCIT:C4775] +synonym: "duodenal benign neoplasm" RELATED [DOID:1737] +synonym: "duodenum benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "neoplasm of the duodenum" BROAD [DOID:1737, NCIT:C2995] +xref: DOID:1737 {source="EFO:1000907", source="MONDO:equivalentTo"} +xref: EFO:1000907 {source="MONDO:equivalentTo"} +xref: MedDRA:10004251 {source="EFO:1000907"} +xref: MESH:D004379 {source="EFO:1000907", source="DOID:1737", source="MONDO:directSiblingOf"} +xref: NCIT:C4775 {source="EFO:1000907", source="MONDO:equivalentTo"} +xref: SCTID:92080005 {source="MONDO:equivalentTo"} +is_a: MONDO:0021375 {source="MONDO:Redundant", source="NCIT:C4775"} ! tumor of duodenum +is_a: MONDO:0021501 {source="MONDO:Redundant", source="NCIT:C4775"} ! benign neoplasm of small intestine +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: closeMatch http://identifiers.org/meddra/10004251 +property_value: exactMatch DOID:1737 +property_value: exactMatch http://identifiers.org/snomedct/92080005 +property_value: exactMatch NCIT:C4775 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0006771 +name: glossitis +def: "Inflammation of the tongue." [NCIT:P378] +synonym: "inflammation of tongue" EXACT [] +synonym: "tongue inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:1456 {source="MONDO:equivalentTo", source="EFO:1000951"} +xref: EFO:1000951 {source="MONDO:equivalentTo"} +xref: ICD10CM:K14.0 {source="DOID:1456", source="MONDO:equivalentTo"} +xref: ICD9:529.0 {source="DOID:1456", source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:1000951"} +xref: MedDRA:10018386 {source="EFO:1000951"} +xref: MESH:D005928 {source="DOID:1456", source="MONDO:equivalentTo", source="EFO:1000951"} +xref: NCIT:C112199 {source="DOID:1456", source="MONDO:otherHierarchy", source="EFO:1000951"} +xref: SCTID:45534005 {source="DOID:1456", source="MONDO:equivalentTo", source="EFO:1000951"} +xref: UMLS:C0017675 {source="DOID:1456", source="MONDO:equivalentTo"} +is_a: MONDO:0001165 {source="DOID:1456", source="MESH:D005928", source="MONDO:Redundant"} ! tongue disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001723 ! tongue +relationship: disease_has_inflammation_site UBERON:0001723 ! tongue +property_value: closeMatch http://identifiers.org/meddra/10018386 +property_value: exactMatch DOID:1456 +property_value: exactMatch http://identifiers.org/mesh/D005928 +property_value: exactMatch http://identifiers.org/snomedct/45534005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017675 +property_value: exactMatch https://icd.codes/icd10cm/K14.0 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: relatedMatch NCIT:C112199 + +[Term] +id: MONDO:0006794 +name: hypersensitivity vasculitis +def: "A small vessel vasculitis affecting the skin and/or internal organs. It is characterized by the presence of neutrophils and fibrinoid necrosis in small arteries and venules. It may be idiopathic or the result of drug treatment, infections, food intake, collagen vascular disorders, inflammatory bowel disease, or cancer." [NCIT:C82863] +synonym: "leukocytoclastic vasculitis" EXACT [NCIT:C82863] +xref: DOID:9809 {source="MONDO:equivalentTo", source="EFO:1000974"} +xref: EFO:1000974 {source="MONDO:equivalentTo"} +xref: ICD9:446.2 {source="DOID:9809"} +xref: ICD9:446.20 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:9809"} +xref: ICD9:446.29 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10020764 {source="EFO:1000974"} +xref: NCIT:C82863 {source="MONDO:equivalentTo"} +xref: SCTID:60555002 {source="MONDO:equivalentTo", source="DOID:9809"} +is_a: MONDO:0000605 {source="DOID:9809/inferred", source="EFO:1000974"} ! hypersensitivity reaction disease +is_a: MONDO:0018882 {source="MONDO:Redundant", source="NCIT:C82863"} ! vasculitis +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_has_basis_in_disruption_of GO:0002524 ! hypersensitivity +property_value: closeMatch http://identifiers.org/meddra/10020764 +property_value: exactMatch DOID:9809 +property_value: exactMatch http://identifiers.org/snomedct/60555002 +property_value: exactMatch NCIT:C82863 +property_value: excluded_subClassOf MONDO:0007004 {source="DOID:9809"} + +[Term] +id: MONDO:0006796 +name: hypertensive encephalopathy +def: "Encephalopathy resulting from hypertension." [NCIT:P378] +xref: DOID:9427 {source="MONDO:equivalentTo", source="EFO:1000976"} +xref: EFO:1000976 {source="MONDO:equivalentTo"} +xref: ICD10CM:I67.4 {source="DOID:9427", source="MONDO:equivalentTo", source="EFO:1000976"} +xref: ICD9:437.2 {source="DOID:9427", source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:1000976"} +xref: MedDRA:10020803 {source="EFO:1000976"} +xref: MESH:D020343 {source="DOID:9427", source="MONDO:equivalentTo", source="EFO:1000976"} +xref: NCIT:C3503 {source="DOID:9427", source="MONDO:equivalentTo", source="EFO:1000976"} +xref: SCTID:50490005 {source="DOID:9427", source="MONDO:equivalentTo", source="EFO:1000976"} +xref: UMLS:C0151620 {source="DOID:9427", source="MONDO:equivalentTo", source="NCIT:C3503"} +is_a: MONDO:0006810 {source="DOID:9427", source="MESH:D020343"} ! intracranial hypertension +intersection_of: MONDO:0005560 ! brain disorder +intersection_of: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +relationship: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +property_value: closeMatch http://identifiers.org/meddra/10020803 +property_value: exactMatch DOID:9427 +property_value: exactMatch http://identifiers.org/mesh/D020343 +property_value: exactMatch http://identifiers.org/snomedct/50490005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151620 +property_value: exactMatch https://icd.codes/icd10cm/I67.4 +property_value: exactMatch NCIT:C3503 +property_value: excluded_subClassOf MONDO:0005156 {source="EFO:1000976"} + +[Term] +id: MONDO:0006797 +name: hypertensive retinopathy +def: "Retinopathy due to hypertension." [NCIT:P378] +xref: DOID:11561 {source="MONDO:equivalentTo", source="EFO:1000977"} +xref: EFO:1000977 {source="MONDO:equivalentTo"} +xref: ICD9:362.11 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11561", source="EFO:1000977"} +xref: MedDRA:10020839 {source="EFO:1000977"} +xref: MESH:D058437 {source="MONDO:equivalentTo", source="DOID:11561", source="EFO:1000977"} +xref: NCIT:C3514 {source="MONDO:equivalentTo", source="DOID:11561", source="EFO:1000977"} +xref: SCTID:6962006 {source="MONDO:equivalentTo", source="DOID:11561", source="EFO:1000977"} +xref: UMLS:C0152132 {source="MONDO:equivalentTo", source="DOID:11561", source="NCIT:C3514"} +is_a: MONDO:0005283 {source="DOID:11561", source="EFO:1000977", source="MESH:D058437", source="MONDO:Redundant", source="NCIT:C3514"} ! retinal disorder +intersection_of: MONDO:0005283 ! retinal disorder +intersection_of: disease_arises_from_feature HP:0000822 ! Hypertension +relationship: disease_arises_from_feature HP:0000822 ! Hypertension +property_value: closeMatch http://identifiers.org/meddra/10020839 +property_value: exactMatch DOID:11561 +property_value: exactMatch http://identifiers.org/mesh/D058437 +property_value: exactMatch http://identifiers.org/snomedct/6962006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152132 +property_value: exactMatch NCIT:C3514 + +[Term] +id: MONDO:0006799 +name: hypothalamic neoplasm +def: "A primary or metastatic neoplasm that affects the hypothalamus." [NCIT:P378] +synonym: "hypothalamic neoplasms" EXACT [NCIT:C3129] +synonym: "hypothalamic tumor" EXACT [NCIT:C3129] +synonym: "hypothalamus neoplasm" EXACT [] +synonym: "hypothalamus tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of hypothalamus" EXACT [MONDO:patterns/neoplasm, NCIT:C3129] +synonym: "neoplasm of the hypothalamus" EXACT [DOID:3644, NCIT:C3129] +synonym: "tumor of hypothalamus" EXACT [MONDO:patterns/neoplasm, NCIT:C3129] +synonym: "tumor of the hypothalamus" EXACT [NCIT:C3129] +xref: DOID:3644 {source="MONDO:equivalentTo", source="EFO:1000979"} +xref: EFO:1000979 {source="MONDO:equivalentTo"} +xref: MESH:D007029 {source="MONDO:equivalentTo", source="DOID:3644", source="EFO:1000979"} +xref: NCIT:C3129 {source="MONDO:equivalentTo", source="DOID:3644", source="EFO:1000979"} +xref: SCTID:254968009 {source="MONDO:equivalentTo", source="DOID:3644"} +xref: UMLS:C0020659 {source="MONDO:equivalentTo", source="DOID:3644", source="NCIT:C3129"} +is_a: MONDO:0002150 {source="MESH:D007029", source="MONDO:Redundant"} ! hypothalamic disorder +is_a: MONDO:0021211 ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001898 ! hypothalamus +property_value: exactMatch DOID:3644 +property_value: exactMatch http://identifiers.org/mesh/D007029 +property_value: exactMatch http://identifiers.org/snomedct/254968009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020659 +property_value: exactMatch NCIT:C3129 +property_value: excluded_subClassOf MONDO:0003766 {source="DOID:3644"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006801 +name: ileal neoplasm +alt_id: MONDO:0021376 +def: "A benign or malignant neoplasm that affects the wall of the ileum. Representative examples include adenoma, carcinoma, and lymphoma." [NCIT:P378] +synonym: "ileal tumor" EXACT [DOID:10156, NCIT:C3130] +synonym: "ileum neoplasm" EXACT [] +synonym: "ileum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "ileum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of ileum" EXACT [MONDO:patterns/neoplasm, NCIT:C3130] +synonym: "neoplasm of the ileum" EXACT [NCIT:C3130] +synonym: "tumor of ileum" EXACT [MONDO:patterns/neoplasm, NCIT:C3130] +synonym: "tumor of the ileum" EXACT [NCIT:C3130] +xref: DOID:10156 {source="MONDO:equivalentTo", source="EFO:1000981"} +xref: EFO:1000981 {source="MONDO:equivalentTo"} +xref: MESH:D007078 {source="MONDO:equivalentTo", source="EFO:1000981", source="DOID:10156"} +xref: NCIT:C3130 {source="MONDO:equivalentTo", source="EFO:1000981", source="DOID:10156"} +xref: SCTID:126835002 {source="MONDO:equivalentTo", source="DOID:10156"} +xref: UMLS:C0020876 {source="NCIT:C3130", source="MONDO:equivalentTo", source="DOID:10156"} +is_a: MONDO:0004251 {source="DOID:10156", source="MONDO:Redundant", source="NCIT:C3130"} ! small intestine neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002116 ! ileum +relationship: disease_has_location UBERON:0002116 ! ileum +property_value: exactMatch DOID:10156 +property_value: exactMatch http://identifiers.org/mesh/D007078 +property_value: exactMatch http://identifiers.org/snomedct/126835002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020876 +property_value: exactMatch NCIT:C3130 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006810 +name: intracranial hypertension +def: "A finding characterized by increased cerebrospinal fluid pressure within the skull." [NCIT:P378] +synonym: "raised intracranial pressure" EXACT [DOID:9428] +xref: DOID:9428 {source="MONDO:equivalentTo", source="EFO:1000992"} +xref: EFO:1000992 {source="MONDO:equivalentTo"} +xref: MedDRA:10022764 {source="EFO:1000992"} +xref: MESH:D019586 {source="DOID:9428", source="MONDO:equivalentTo", source="EFO:1000992"} +xref: NCIT:C84791 {source="DOID:9428", source="MONDO:otherHierarchy", source="EFO:1000992"} +xref: UMLS:C0151740 {source="DOID:9428", source="MONDO:equivalentTo"} +is_a: MONDO:0005044 {source="EFO:1000992"} ! hypertensive disorder +is_a: MONDO:0005560 {source="DOID:9428", source="MESH:D019586"} ! brain disorder +is_a: MONDO:0043218 ! neurovascular disorder +property_value: closeMatch http://identifiers.org/meddra/10022764 +property_value: exactMatch DOID:9428 +property_value: exactMatch http://identifiers.org/mesh/D019586 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151740 +property_value: relatedMatch NCIT:C84791 + +[Term] +id: MONDO:0006814 +name: iritis +def: "Inflammation of the iris." [NCIT:P378] +synonym: "inflammation of iris" EXACT [] +synonym: "iris inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "iritis" EXACT [MONDO:ambiguous] +synonym: "iritis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1406 {source="MONDO:equivalentTo", source="EFO:1000997"} +xref: EFO:1000997 {source="MONDO:equivalentTo"} +xref: HP:0001101 {source="MONDO:otherHierarchy"} +xref: MedDRA:10022955 {source="EFO:1000997"} +xref: MESH:D007500 {source="MONDO:equivalentTo", source="EFO:1000997", source="DOID:1406"} +xref: NCIT:C50621 {source="MONDO:equivalentTo", source="EFO:1000997", source="DOID:1406"} +xref: SCTID:65074000 {source="MONDO:equivalentTo", source="EFO:1000997", source="DOID:1406"} +xref: UMLS:C0022081 {source="NCIT:C50621", source="MONDO:equivalentTo", source="DOID:1406"} +is_a: MONDO:0002289 {source="DOID:1406", source="MESH:D007500", source="MONDO:Redundant"} ! iris disorder +is_a: MONDO:0020283 ! uveitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001769 ! iris +relationship: disease_has_inflammation_site UBERON:0001769 ! iris +property_value: closeMatch http://identifiers.org/meddra/10022955 +property_value: exactMatch DOID:1406 +property_value: exactMatch http://identifiers.org/mesh/D007500 +property_value: exactMatch http://identifiers.org/snomedct/65074000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022081 +property_value: exactMatch NCIT:C50621 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "iritis (disease)" xsd:string + +[Term] +id: MONDO:0006815 +name: jejunal cancer +def: "A malignant neoplasm involving the jejunum." [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of jejunum" EXACT [MONDO:patterns/cancer] +synonym: "jejunum cancer" EXACT [MONDO:patterns/location] +synonym: "malignant jejunum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of jejunum" EXACT [DOID:13499, ICD9CM:152.1, MONDO:patterns/cancer, MTH:U001249] +synonym: "malignant tumor of jejunum" EXACT [DOID:13499] +xref: DOID:13499 {source="MONDO:equivalentTo", source="EFO:1000998"} +xref: EFO:1000998 {source="MONDO:equivalentTo"} +xref: ICD9:152.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:13499"} +xref: MedDRA:10023166 {source="EFO:1000998"} +xref: SCTID:363404008 {source="MONDO:equivalentTo", source="DOID:13499"} +xref: UMLS:C0153427 {source="MONDO:equivalentTo", source="DOID:13499"} +is_a: MONDO:0000956 {source="DOID:13499", source="MONDO:Redundant", source="MONDO:cjm"} ! small intestine cancer +is_a: MONDO:0002564 {source="MONDO:Redundant"} ! jejunal neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002115 ! jejunum +property_value: closeMatch http://identifiers.org/meddra/10023166 +property_value: exactMatch DOID:13499 +property_value: exactMatch http://identifiers.org/snomedct/363404008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153427 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006816 +name: arthropathy +def: "Any disorder of the joints." [NCIT:C35760] +synonym: "ankylosis of ankle and foot joint" NARROW [DOID:381] +synonym: "ankylosis of forearm joint" NARROW [DOID:381] +synonym: "ankylosis of hand joint" NARROW [DOID:381] +synonym: "ankylosis of joint of ankle and/or foot" EXACT [DOID:381] +synonym: "ankylosis of joint of forearm" EXACT [DOID:381] +synonym: "ankylosis of joint of hand" EXACT [DOID:381] +synonym: "ankylosis of joint of lower leg" EXACT [DOID:381] +synonym: "ankylosis of joint of multiple sites" NARROW [DOID:381] +synonym: "ankylosis of joint of pelvic region and thigh" NARROW [DOID:381] +synonym: "ankylosis of joint of shoulder region" NARROW [DOID:381] +synonym: "ankylosis of joint of upper arm" EXACT [DOID:381] +synonym: "ankylosis of lower leg joint" NARROW [DOID:381] +synonym: "ankylosis of multiple joints" NARROW [DOID:381] +synonym: "ankylosis of upper arm joint" NARROW [DOID:381] +synonym: "arthropathy" EXACT [NCIT:C35760] +synonym: "arthrosis" RELATED [] +synonym: "disease of skeletal joint" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of skeletal joint" EXACT [] +synonym: "disorder of joint" RELATED [] +synonym: "disorder of skeletal joint" EXACT [MONDO:patterns/location_top] +synonym: "disorder, Joint" EXACT [NCIT:C35760] +synonym: "infectious arthropathy" NARROW [DOID:381] +synonym: "Joint ankylosis of the ankle and foot" NARROW [DOID:381] +synonym: "Joint ankylosis of the ankle and/or foot" EXACT [DOID:381] +synonym: "Joint ankylosis of the forearm" NARROW [DOID:381] +synonym: "Joint ankylosis of the hand" NARROW [DOID:381] +synonym: "Joint ankylosis of the lower leg" NARROW [DOID:381] +synonym: "Joint ankylosis of the pelvic region and thigh" NARROW [DOID:381] +synonym: "Joint ankylosis of the shoulder region" NARROW [DOID:381] +synonym: "Joint ankylosis of the upper arm" NARROW [DOID:381] +synonym: "joint disease" RELATED [] +synonym: "Joint disorder" EXACT [NCIT:C35760] +synonym: "joint disorder" RELATED [] +synonym: "skeletal joint disease" EXACT [MONDO:patterns/location] +synonym: "skeletal joint disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:381 {source="MONDO:equivalentTo", source="EFO:1000999"} +xref: EFO:1000999 {source="MONDO:equivalentTo"} +xref: ICD9:711 {source="DOID:381"} +xref: ICD9:716.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:716.88 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:716.9 {source="DOID:381"} +xref: ICD9:716.90 {source="DOID:381", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:716.98 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:719.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:719.88 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:719.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:719.9 {source="DOID:381"} +xref: ICD9:719.90 {source="DOID:381", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:719.98 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10003285 {source="EFO:1000999"} +xref: MESH:D007592 {source="DOID:381", source="MONDO:equivalentTo"} +xref: NCIT:C35760 {source="DOID:381", source="MONDO:equivalentTo", source="EFO:1000999"} +xref: SCTID:399269003 {source="DOID:381", source="MONDO:equivalentTo", source="EFO:1000999"} +xref: UMLS:C0022408 {source="NCIT:C35760", source="DOID:381", source="MONDO:equivalentTo"} +is_a: MONDO:0005172 ! skeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000982 ! skeletal joint +relationship: disease_has_location UBERON:0000982 ! skeletal joint +property_value: closeMatch http://identifiers.org/meddra/10003285 +property_value: exactMatch DOID:381 +property_value: exactMatch http://identifiers.org/mesh/D007592 +property_value: exactMatch http://identifiers.org/snomedct/399269003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022408 +property_value: exactMatch NCIT:C35760 +property_value: excluded_subClassOf MONDO:0002614 {source="DOID:381"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0006834 +name: lip cancer +def: "A primary or metastatic malignant neoplasm involving the lip." [NCIT:C7485] +synonym: "cancer of lip" EXACT [MONDO:patterns/cancer] +synonym: "lip cancer" EXACT [MONDO:patterns/location] +synonym: "malignant Lip neoplasm" EXACT [NCIT:C7485] +synonym: "malignant lip neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant Lip tumor" EXACT [NCIT:C7485] +synonym: "malignant neoplasm of commissure of lip" EXACT [DOID:8564] +synonym: "malignant neoplasm of external Lip, not specified as upper or lower" EXACT [DOID:8564] +synonym: "malignant neoplasm of labial commissure of lip" EXACT [DOID:8564] +synonym: "malignant neoplasm of Lip" EXACT [NCIT:C7485] +synonym: "malignant neoplasm of lip" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of lip, external" EXACT [DOID:8564] +synonym: "malignant neoplasm of lip, inner aspect" EXACT [DOID:8564, MTH:NOCODE] +synonym: "malignant neoplasm of lip, unspecified" EXACT [DOID:8564] +synonym: "malignant neoplasm of lip, unspecified, inner aspect" EXACT [DOID:8564] +synonym: "malignant neoplasm of lip, unspecified, vermilion border" EXACT [DOID:8564] +synonym: "malignant neoplasm of lip, vermilion border" EXACT [DOID:8564] +synonym: "malignant neoplasm of lower lip, buccal aspect" EXACT [DOID:8564] +synonym: "malignant neoplasm of lower lip, inner aspect" EXACT [DOID:8564] +synonym: "malignant neoplasm of lower lip, mucosa" EXACT [DOID:8564] +synonym: "malignant neoplasm of lower lip, oral aspect" EXACT [DOID:8564] +synonym: "malignant neoplasm of oral aspect of lip, not specified whether upper or lower" EXACT [DOID:8564] +synonym: "malignant neoplasm of other sites of lip" EXACT [DOID:8564] +synonym: "malignant neoplasm of the Lip" EXACT [NCIT:C7485] +synonym: "malignant neoplasm of vermilion border of lip" EXACT [DOID:8564] +synonym: "malignant tumor of commissure of lip" EXACT [DOID:8564, MTH:NOCODE] +synonym: "malignant tumor of labial mucosa" EXACT [DOID:8564] +synonym: "malignant tumor of Lip" EXACT [NCIT:C7485] +synonym: "malignant tumor of lower labial mucosa" EXACT [DOID:8564] +synonym: "malignant tumor of the Lip" EXACT [DOID:8564, NCIT:C7485] +synonym: "malignant tumour of labial commissure" EXACT [DOID:8564] +synonym: "malignant tumour of lip" EXACT [DOID:8564] +xref: DOID:8564 {source="MONDO:equivalentTo", source="EFO:1001019"} +xref: EFO:1001019 {source="MONDO:equivalentTo"} +xref: ICD10CM:C00 {source="MONDO:equivalentTo", source="DOID:8564"} +xref: ICD9:140 {source="DOID:8564"} +xref: ICD9:140.5 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:140.6 {source="DOID:8564"} +xref: ICD9:140.8 {source="DOID:8564"} +xref: MedDRA:10007089 {source="EFO:1001019"} +xref: MESH:D008048 {source="MONDO:equivalentTo", source="EFO:1001019", source="DOID:8564"} +xref: NCIT:C7485 {source="MONDO:equivalentTo", source="DOID:8564"} +xref: SCTID:187622006 {source="MONDO:equivalentTo"} +is_a: MONDO:0000653 ! integumentary system cancer +is_a: MONDO:0005515 {source="DOID:8564", source="EFO:1001019"} ! oral cavity cancer +is_a: MONDO:0021249 {source="MONDO:Redundant", source="NCIT:C7485"} ! lip neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001833 ! lip +property_value: closeMatch http://identifiers.org/meddra/10007089 +property_value: exactMatch DOID:8564 +property_value: exactMatch http://identifiers.org/mesh/D008048 +property_value: exactMatch http://identifiers.org/snomedct/187622006 +property_value: exactMatch https://icd.codes/icd10cm/C00 +property_value: exactMatch NCIT:C7485 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006849 +name: mastitis +def: "Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection. Mastitis can also occur in non-breastfeeding women, and rarely in men." [https://www.nhs.uk/conditions/mastitis/, NCIT:P378, Wikipedia:Mastitis#Types] +synonym: "breast infection" EXACT [NCIT:C53662] +synonym: "breast inflammation" EXACT [DOID:10690, MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of breast" EXACT [] +synonym: "inflammatory breast disease" EXACT [DOID:10690] +synonym: "inflammatory disease of breast" EXACT [DOID:10690, ICD9CM:611.0] +xref: DOID:10690 {source="EFO:1001034", source="MONDO:equivalentTo"} +xref: EFO:1001034 {source="MONDO:equivalentTo"} +xref: MedDRA:10026883 {source="EFO:1001034"} +xref: MESH:D008413 {source="EFO:1001034", source="MONDO:equivalentTo", source="DOID:10690"} +xref: NCIT:C53662 {source="EFO:1001034", source="MONDO:equivalentTo", source="DOID:10690"} +xref: SCTID:45198002 {source="EFO:1001034", source="MONDO:equivalentTo", source="DOID:10690"} +xref: UMLS:C0024894 {source="MONDO:equivalentTo", source="DOID:10690", source="NCIT:C53662"} +xref: UMLS:C0392317 {source="MONDO:equivalentTo"} +is_a: MONDO:0002657 {source="DOID:10690", source="MESH:D008413", source="MONDO:Redundant", source="NCIT:C53662/inferred"} ! breast disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000310 ! breast +relationship: disease_has_inflammation_site UBERON:0000310 ! breast +property_value: closeMatch http://identifiers.org/meddra/10026883 +property_value: exactMatch DOID:10690 +property_value: exactMatch http://identifiers.org/mesh/D008413 +property_value: exactMatch http://identifiers.org/snomedct/45198002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024894 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0392317 +property_value: exactMatch NCIT:C53662 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006850 +name: maxillary sinus neoplasm +alt_id: MONDO:0021213 +def: "A benign or malignant neoplasm that affects the maxillary sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:C3219] +synonym: "maxillary antrum neoplasm" EXACT [NCIT:C3219] +synonym: "maxillary antrum tumor" EXACT [NCIT:C3219] +synonym: "maxillary sinus neoplasm" EXACT [NCIT:C3219] +synonym: "maxillary sinus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "maxillary sinus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3219] +synonym: "maxillofacial sinus neoplasm" EXACT [NCIT:C3219] +synonym: "maxillofacial sinus tumor" EXACT [NCIT:C3219] +synonym: "neoplasm of maxillary antrum" EXACT [NCIT:C3219] +synonym: "neoplasm of maxillary sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C3219] +synonym: "neoplasm of maxillofacial sinus" EXACT [NCIT:C3219] +synonym: "neoplasm of the maxillary antrum" EXACT [NCIT:C3219] +synonym: "neoplasm of the maxillary sinus" EXACT [NCIT:C3219] +synonym: "neoplasm of the maxillofacial sinus" EXACT [NCIT:C3219] +synonym: "tumor of maxillary antrum" EXACT [NCIT:C3219] +synonym: "tumor of maxillary sinus" EXACT [MONDO:patterns/neoplasm, NCIT:C3219] +synonym: "tumor of maxillofacial sinus" EXACT [DOID:1358, NCIT:C3219] +synonym: "tumor of the maxillary antrum" EXACT [NCIT:C3219] +synonym: "tumor of the maxillary sinus" EXACT [NCIT:C3219] +synonym: "tumor of the maxillofacial sinus" EXACT [NCIT:C3219] +xref: DOID:1358 {source="EFO:1001035", source="MONDO:equivalentTo"} +xref: EFO:1001035 {source="MONDO:equivalentTo"} +xref: MedDRA:10026130 {source="EFO:1001035"} +xref: MESH:D008444 {source="EFO:1001035", source="MONDO:equivalentTo", source="DOID:1358"} +xref: NCIT:C3219 {source="EFO:1001035", source="MONDO:equivalentTo", source="DOID:1358"} +xref: SCTID:126676009 {source="MONDO:equivalentTo", source="DOID:1358"} +xref: UMLS:C0024958 {source="MONDO:equivalentTo", source="DOID:1358", source="NCIT:C3219"} +is_a: MONDO:0005289 {source="DOID:1358", source="EFO:1001035", source="MONDO:Redundant", source="NCIT:C3219"} ! paranasal sinus neoplasm +is_a: MONDO:0005841 ! maxillary neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001764 ! maxillary sinus +relationship: disease_has_location UBERON:0001764 ! maxillary sinus +property_value: closeMatch http://identifiers.org/meddra/10026130 +property_value: exactMatch DOID:1358 +property_value: exactMatch http://identifiers.org/mesh/D008444 +property_value: exactMatch http://identifiers.org/snomedct/126676009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024958 +property_value: exactMatch NCIT:C3219 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006858 +name: mouth disorder +def: "A disease involving the mouth." [https://orcid.org/0000-0002-6601-2165] +comment: Reason: grouping class. Term to consider: none +subset: obsoletion_candidate +synonym: "disease of mouth" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of mouth" EXACT [] +synonym: "disorder of mouth" EXACT [MONDO:patterns/location_top] +synonym: "mouth disease" EXACT [MONDO:patterns/location] +synonym: "mouth disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "oral disease" EXACT [NCIT:C3240] +synonym: "oral disorder" EXACT [NCIT:C3240] +xref: DOID:403 {source="MONDO:equivalentTo", source="EFO:1001047"} +xref: EFO:1001047 {source="MONDO:equivalentTo"} +xref: ICD9:528.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009059 {source="DOID:403", source="MONDO:equivalentTo", source="EFO:1001047"} +xref: NCIT:C3240 {source="DOID:403", source="MONDO:equivalentTo"} +xref: SCTID:118938008 {source="DOID:403", source="MONDO:equivalentTo", source="EFO:1001047"} +xref: UMLS:C0026636 {source="DOID:403", source="MONDO:equivalentTo"} +is_a: MONDO:0005042 ! head disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000165 ! mouth +relationship: disease_has_location UBERON:0000165 ! mouth +property_value: exactMatch DOID:403 +property_value: exactMatch http://identifiers.org/mesh/D009059 +property_value: exactMatch http://identifiers.org/snomedct/118938008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026636 +property_value: exactMatch NCIT:C3240 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml +property_value: IAO:0006012 "2022-08-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4968 + +[Term] +id: MONDO:0006873 +name: nutritional deficiency disease +def: "A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)" [MESH:D003677] +synonym: "malnourished" EXACT [NCIT:C3669] +synonym: "malnutrition" EXACT [] +xref: DOID:5113 {source="EFO:1001067", source="MONDO:equivalentTo"} +xref: EFO:1001067 {source="MONDO:equivalentTo"} +xref: ICD10CM:E40-E46 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:269.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:269.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10046058 {source="EFO:1001067"} +xref: MESH:D003677 {source="DOID:5113", source="EFO:1001067", source="MONDO:equivalentTo"} +xref: NCIT:C3669 {source="MONDO:equivalentTo"} +xref: SCTID:363246002 {source="MONDO:equivalentTo"} +xref: SCTID:70241007 {source="EFO:1001067", source="MONDO:equivalentTo"} +is_a: MONDO:0005137 {source="DOID:5113", source="EFO:1001067", source="MESH:D003677/inferred", source="NCIT:C3669"} ! nutritional disorder +property_value: closeMatch http://identifiers.org/meddra/10046058 +property_value: exactMatch DOID:5113 +property_value: exactMatch http://identifiers.org/mesh/D003677 +property_value: exactMatch http://identifiers.org/snomedct/363246002 +property_value: exactMatch http://identifiers.org/snomedct/70241007 +property_value: exactMatch https://icd.codes/icd10cm/E40-E46 +property_value: exactMatch NCIT:C3669 + +[Term] +id: MONDO:0006877 +name: oophoritis +def: "Inflammation of the ovary, generally caused by an ascending infection of organisms from the endocervix." [MESH:D009869] +synonym: "inflammation of ovary" EXACT [] +synonym: "ovary inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:10974 {source="MONDO:equivalentTo", source="EFO:1001071"} +xref: EFO:1001071 {source="MONDO:equivalentTo"} +xref: MedDRA:10030345 {source="EFO:1001071"} +xref: MESH:D009869 {source="DOID:10974", source="MONDO:equivalentTo", source="EFO:1001071"} +xref: SCTID:76047005 {source="DOID:10974", source="MONDO:equivalentTo", source="EFO:1001071"} +xref: UMLS:C0029051 {source="DOID:10974", source="MONDO:equivalentTo"} +is_a: MONDO:0005558 {source="DOID:10974", source="EFO:1001071", source="MESH:D009869", source="MONDO:Redundant"} ! ovarian disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000992 ! ovary +relationship: disease_has_inflammation_site UBERON:0000992 ! ovary +property_value: closeMatch http://identifiers.org/meddra/10030345 +property_value: exactMatch DOID:10974 +property_value: exactMatch http://identifiers.org/mesh/D009869 +property_value: exactMatch http://identifiers.org/snomedct/76047005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029051 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006879 +name: optic papillitis +def: "Swelling of the optic disk, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause optic atrophy and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)" [MESH:D010211] +synonym: "Choked disk" EXACT [MESH:D010211] +synonym: "Choked disks" EXACT [MESH:D010211] +synonym: "decreased intraocular pressure associated papilledema" EXACT [MESH:D010211] +synonym: "decreased intraocular pressure-associated papilledema" EXACT [MESH:D010211] +synonym: "disk, Choked" EXACT [MESH:D010211] +synonym: "disks, Choked" EXACT [MESH:D010211] +synonym: "edema of the optic disc" EXACT [MESH:D010211] +synonym: "edema, optic disk" EXACT [MESH:D010211] +synonym: "edema, optic papilla" EXACT [MESH:D010211] +synonym: "edema, retinal" RELATED [MESH:D010211] +synonym: "Edemas, optic disk" EXACT [MESH:D010211] +synonym: "Edemas, retinal" RELATED [MESH:D010211] +synonym: "increased intracranial pressure associated papilledema" EXACT [MESH:D010211] +synonym: "increased intracranial pressure-associated papilledema" EXACT [MESH:D010211] +synonym: "inflammation of optic disc" EXACT [] +synonym: "optic disc inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "optic discitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "optic disk edema" EXACT [MESH:D010211] +synonym: "optic nerve papillitis" EXACT [MESH:D010211] +synonym: "optic papilla edema" EXACT [MESH:D010211] +synonym: "optic papillitis" EXACT [MESH:D010211] +synonym: "papilledema associated with decreased intraocular pressure" EXACT [MESH:D010211] +synonym: "papilledema associated with increased intracranial pressure" EXACT [MESH:D010211] +synonym: "papillitis" EXACT [DOID:10175, MESH:D010211] +synonym: "papillitis, optic" EXACT [MESH:D010211] +synonym: "papillitis, optic nerve" EXACT [MESH:D010211] +synonym: "retinal edema" RELATED [MESH:D010211] +synonym: "retinal Edemas" RELATED [MESH:D010211] +xref: DOID:10175 {source="EFO:1001074", source="MONDO:equivalentTo"} +xref: EFO:1001074 {source="MONDO:equivalentTo"} +xref: ICD9:362.83 {source="DOID:10175", source="MONDO:directSiblingOf"} +xref: ICD9:377.0 {source="DOID:10175"} +xref: ICD9:377.00 {source="MONDO:relatedTo", source="DOID:10175"} +xref: ICD9:377.01 {source="DOID:10175"} +xref: ICD9:377.31 {source="EFO:1001074", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10175"} +xref: MedDRA:10030948 {source="EFO:1001074"} +xref: MESH:D010211 {source="EFO:1001074", source="MONDO:equivalentTo", source="DOID:10175"} +xref: NCIT:C3307 {source="MONDO:otherHierarchy", source="DOID:10175"} +xref: SCTID:6141006 {source="DOID:10175", source="MONDO:directSiblingOf"} +xref: SCTID:73221001 {source="EFO:1001074", source="MONDO:equivalentTo", source="DOID:10175"} +is_a: MONDO:0002708 ! retinitis +is_a: MONDO:0005885 {source="DOID:10175"} ! optic neuritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001783 ! optic disc +relationship: disease_has_inflammation_site UBERON:0001783 ! optic disc +property_value: closeMatch http://identifiers.org/meddra/10030948 +property_value: exactMatch DOID:10175 +property_value: exactMatch http://identifiers.org/mesh/D010211 +property_value: exactMatch http://identifiers.org/snomedct/73221001 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006882 +name: orchitis +def: "Inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation." [NCIT:P378] +synonym: "Inflammation of testis" EXACT [DOID:2518] +synonym: "inflammation of testis" EXACT [] +synonym: "orchitis" EXACT [MONDO:ambiguous] +synonym: "orchitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "Orchititis" EXACT [DOID:2518] +synonym: "testis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "testisitis" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2518 {source="EFO:1001078", source="MONDO:equivalentTo"} +xref: EFO:1001078 {source="MONDO:equivalentTo"} +xref: HP:0100796 {source="MONDO:otherHierarchy"} +xref: ICD10CM:N45.2 {source="MONDO:equivalentTo", source="DOID:2518"} +xref: MedDRA:10031064 {source="EFO:1001078"} +xref: MESH:D009920 {source="EFO:1001078", source="MONDO:equivalentTo", source="DOID:2518"} +xref: NCIT:C97145 {source="EFO:1001078", source="MONDO:equivalentTo", source="DOID:2518"} +xref: SCTID:274718005 {source="EFO:1001078", source="MONDO:equivalentTo", source="DOID:2518"} +xref: UMLS:C0029191 {source="MONDO:equivalentTo", source="NCIT:C97145", source="DOID:2518"} +is_a: MONDO:0002329 {source="DOID:2518", source="MESH:D009920", source="MONDO:Redundant", source="NCIT:C97145/inferred"} ! testicular disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000473 ! testis +relationship: disease_has_inflammation_site UBERON:0000473 ! testis +property_value: closeMatch http://identifiers.org/meddra/10031064 +property_value: exactMatch DOID:2518 +property_value: exactMatch http://identifiers.org/mesh/D009920 +property_value: exactMatch http://identifiers.org/snomedct/274718005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029191 +property_value: exactMatch https://icd.codes/icd10cm/N45.2 +property_value: exactMatch NCIT:C97145 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "orchitis (disease)" xsd:string + +[Term] +id: MONDO:0006887 +name: parametritis +def: "Inflammation of the parametrium, the connective tissue of the pelvic floor, extending from the subserous coat of the uterus laterally between the layers of the broad ligament." [MESH:D010249] +synonym: "inflammation of parametrium" EXACT [] +synonym: "parametrium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "pelvic cellulitis" EXACT [DOID:1260] +xref: DOID:1260 {source="MONDO:equivalentTo", source="EFO:1001084"} +xref: EFO:1001084 {source="MONDO:equivalentTo"} +xref: MESH:D010249 {source="MONDO:equivalentTo", source="EFO:1001084", source="DOID:1260"} +xref: SCTID:280483007 {source="MONDO:equivalentTo", source="DOID:1260"} +xref: UMLS:C0030455 {source="MONDO:equivalentTo", source="DOID:1260"} +is_a: MONDO:0000922 {source="DOID:1260", source="MESH:D010249"} ! pelvic inflammatory disease +is_a: MONDO:0002654 ! uterine disorder +is_a: MONDO:0043786 ! serositis +is_a: MONDO:0045043 ! disorder of uterine broad ligament +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0010391 ! parametrium +relationship: disease_has_inflammation_site UBERON:0010391 ! parametrium +property_value: exactMatch DOID:1260 +property_value: exactMatch http://identifiers.org/mesh/D010249 +property_value: exactMatch http://identifiers.org/snomedct/280483007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030455 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006895 +name: penile neoplasm +def: "A benign, borderline, or malignant neoplasm that affects the penis. Representative examples include penile hemangioma, penile intraepithelial neoplasia, and penile carcinoma." [NCIT:C3317] +synonym: "neoplasm of penis" EXACT [MONDO:patterns/neoplasm, NCIT:C3317] +synonym: "neoplasm of the penis" EXACT [NCIT:C3317] +synonym: "penile neoplasm" EXACT [NCIT:C3317] +synonym: "penile neoplasms" EXACT [NCIT:C3317] +synonym: "penile tumor" EXACT [DOID:11624, NCIT:C3317] +synonym: "penis neoplasm" EXACT [] +synonym: "penis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "penis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of penis" EXACT [MONDO:patterns/neoplasm, NCIT:C3317] +synonym: "tumor of the penis" EXACT [NCIT:C3317] +xref: DOID:11624 {source="MONDO:equivalentTo", source="EFO:1001094"} +xref: EFO:1001094 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10061913 {source="EFO:1001094"} +xref: MESH:D010412 {source="DOID:11624", source="MONDO:equivalentTo", source="EFO:1001094"} +xref: NCIT:C3317 {source="DOID:11624", source="MONDO:equivalentTo", source="EFO:1001094"} +xref: ONCOTREE:PENIS {source="MONDO:equivalentTo"} +xref: SCTID:126896003 {source="DOID:11624", source="MONDO:equivalentTo"} +xref: UMLS:C0030849 {source="DOID:11624", source="MONDO:equivalentTo", source="NCIT:C3317"} +is_a: MONDO:0002036 {source="DOID:11624", source="MESH:D010412", source="MONDO:Redundant", source="NCIT:C3317"} ! penile disorder +is_a: MONDO:0024582 ! male reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: closeMatch http://identifiers.org/meddra/10061913 +property_value: exactMatch DOID:11624 +property_value: exactMatch http://identifiers.org/mesh/D010412 +property_value: exactMatch http://identifiers.org/snomedct/126896003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030849 +property_value: exactMatch NCIT:C3317 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006901 +name: peritoneal neoplasm +def: "A benign or malignant neoplasm that affects the peritoneal cavity. Representative examples of benign neoplasms include adenomatoid tumor and disseminated peritoneal leiomyomatosis. Representative examples of malignant neoplasms include primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma." [NCIT:C3322] +synonym: "neoplasm of peritoneum" EXACT [MONDO:patterns/neoplasm] +synonym: "peritoneal neoplasm" EXACT [NCIT:C3322] +synonym: "peritoneum neoplasm" EXACT [] +synonym: "peritoneum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "peritoneum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of peritoneum" EXACT [MONDO:patterns/neoplasm] +xref: EFO:1001100 {source="MONDO:equivalentTo"} +xref: MedDRA:10061344 {source="EFO:1001100"} +xref: MESH:D010534 {source="EFO:1001100", source="MONDO:equivalentTo"} +xref: NCIT:C3322 {source="EFO:1001100", source="MONDO:equivalentTo"} +xref: SCTID:126865007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="EFO:1001100", source="MESH:D010534/inferred", source="MONDO:Redundant", source="NCIT:C3322/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002358 ! peritoneum +relationship: disease_has_location UBERON:0002358 ! peritoneum +property_value: closeMatch http://identifiers.org/meddra/10061344 +property_value: exactMatch http://identifiers.org/mesh/D010534 +property_value: exactMatch http://identifiers.org/snomedct/126865007 +property_value: exactMatch NCIT:C3322 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006918 +name: posterior uveitis +def: "Inflammation of the choroid as well as the retina and vitreous body. Some form of visual disturbance is usually present. The most important characteristics of posterior uveitis are vitreous opacities, choroiditis, and chorioretinitis." [MESH:D015866] +comment: Editor note: choroid=PU. in MESH PUitis is defined to be choroid+retina+VB, and isa panuveitis. TODO check ORDO, GARD +subset: gard_rare +synonym: "chorioretinal region inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of chorioretinal region" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "uveitis, posterior" EXACT [DOID:12574] +xref: DOID:12574 {source="MONDO:equivalentTo", source="EFO:1001119"} +xref: EFO:1001119 {source="MONDO:equivalentTo"} +xref: GARD:0004457 {source="MONDO:equivalentTo"} +xref: MedDRA:10036370 {source="EFO:1001119"} +xref: MESH:D015866 {source="MONDO:equivalentTo", source="DOID:12574", source="EFO:1001119"} +xref: NCIT:C35111 {source="MONDO:relatedTo", source="DOID:12574", source="EFO:1001119", source="MONDO:directSiblingOf"} +xref: Orphanet:280892 {source="GARD:0004457", source="MONDO:directSiblingOf"} +xref: SCTID:43363007 {source="MONDO:equivalentTo", source="DOID:12574", source="EFO:1001119"} +xref: SCTID:46627006 {source="DOID:12574", source="MONDO:directSiblingOf"} +xref: UMLS:C0042167 {source="DOID:12574", source="MONDO:directSiblingOf"} +is_a: MONDO:0020283 {source="DOID:12574/inferred", source="EFO:1001119/inferred", source="MESH:D015866/inferred", source="NCIT:C35111"} ! uveitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0019207 ! chorioretinal region +relationship: disease_has_inflammation_site UBERON:0019207 ! chorioretinal region +property_value: closeMatch http://identifiers.org/meddra/10036370 +property_value: exactMatch DOID:12574 +property_value: exactMatch http://identifiers.org/mesh/D015866 +property_value: exactMatch http://identifiers.org/snomedct/43363007 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006937 +name: pulpitis +def: "Inflammation of the dental pulp." [NCIT:P378] +synonym: "dental pulp inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of dental pulp" EXACT [] +xref: DOID:11121 {source="MONDO:equivalentTo", source="EFO:1001139"} +xref: EFO:1001139 {source="MONDO:equivalentTo"} +xref: ICD10CM:K04.0 {source="MONDO:equivalentTo", source="DOID:11121", source="EFO:1001139"} +xref: ICD9:522.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11121", source="EFO:1001139"} +xref: MedDRA:10037463 {source="EFO:1001139"} +xref: MESH:D011671 {source="MONDO:equivalentTo", source="DOID:11121", source="EFO:1001139"} +xref: NCIT:C52595 {source="MONDO:otherHierarchy", source="DOID:11121", source="EFO:1001139"} +xref: SCTID:32620007 {source="MONDO:equivalentTo", source="DOID:11121", source="EFO:1001139"} +xref: UMLS:C0034103 {source="MONDO:equivalentTo", source="DOID:11121"} +is_a: MONDO:0003394 {source="DOID:11121", source="MESH:D011671", source="MONDO:Redundant"} ! dental pulp disorder +is_a: MONDO:0005113 {source="EFO:1001139"} ! bacterial infectious disease +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001754 ! dental pulp +relationship: disease_has_inflammation_site UBERON:0001754 ! dental pulp +property_value: closeMatch http://identifiers.org/meddra/10037463 +property_value: exactMatch DOID:11121 +property_value: exactMatch http://identifiers.org/mesh/D011671 +property_value: exactMatch http://identifiers.org/snomedct/32620007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034103 +property_value: exactMatch https://icd.codes/icd10cm/K04.0 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: relatedMatch NCIT:C52595 + +[Term] +id: MONDO:0006938 +name: pyelitis +def: "Inflammation of the renal pelvis." [NCIT:P378] +synonym: "inflammation of renal pelvis" EXACT [] +synonym: "renal pelvis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:2744 {source="EFO:1001140", source="MONDO:equivalentTo"} +xref: EFO:1001140 {source="MONDO:equivalentTo"} +xref: MedDRA:10037584 {source="EFO:1001140"} +xref: MESH:D011702 {source="EFO:1001140", source="MONDO:equivalentTo", source="DOID:2744"} +xref: NCIT:C34964 {source="EFO:1001140", source="MONDO:equivalentTo", source="DOID:2744"} +xref: SCTID:27174002 {source="EFO:1001140", source="MONDO:equivalentTo", source="DOID:2744"} +xref: UMLS:C0034183 {source="MONDO:equivalentTo", source="DOID:2744", source="NCIT:C34964"} +is_a: MONDO:0001166 ! nephritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001224 ! renal pelvis +relationship: disease_has_inflammation_site UBERON:0001224 ! renal pelvis +property_value: closeMatch http://identifiers.org/meddra/10037584 +property_value: exactMatch DOID:2744 +property_value: exactMatch http://identifiers.org/mesh/D011702 +property_value: exactMatch http://identifiers.org/snomedct/27174002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034183 +property_value: exactMatch NCIT:C34964 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0006950 +name: retinal vasculitis +def: "Inflammation of the retinal vasculature with various causes including infectious disease; lupus erythematosus, systemic; multiple sclerosis; behcet syndrome; and chorioretinitis." [MESH:D031300] +synonym: "retinal vasculitis" EXACT [DOID:11563, ICD9CM:362.18] +xref: DOID:11563 {source="EFO:1001156", source="MONDO:equivalentTo"} +xref: EFO:1001156 {source="MONDO:equivalentTo"} +xref: ICD9:362.18 {source="EFO:1001156", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11563"} +xref: MedDRA:10038905 {source="EFO:1001156"} +xref: MESH:D031300 {source="EFO:1001156", source="MONDO:equivalentTo", source="DOID:11563"} +xref: SCTID:77628002 {source="EFO:1001156", source="MONDO:equivalentTo", source="DOID:11563"} +xref: UMLS:C0152026 {source="MONDO:equivalentTo", source="DOID:11563"} +is_a: MONDO:0002311 {source="DOID:11563"} ! retinal vascular disorder +is_a: MONDO:0002708 ! retinitis +is_a: MONDO:0018882 {source="DOID:11563", source="EFO:1001156", source="MESH:D031300", source="MONDO:Redundant"} ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0004864 ! vasculature of retina +relationship: disease_has_inflammation_site UBERON:0004864 ! vasculature of retina +property_value: closeMatch http://identifiers.org/meddra/10038905 +property_value: exactMatch DOID:11563 +property_value: exactMatch http://identifiers.org/mesh/D031300 +property_value: exactMatch http://identifiers.org/snomedct/77628002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152026 + +[Term] +id: MONDO:0006955 +name: rheumatic heart disease +def: "An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction." [NCIT:C34882] +synonym: "disease, rheumatic heart" EXACT [NCIT:C34882] +synonym: "heart disease, rheumatic" EXACT [NCIT:C34882] +synonym: "RHD" EXACT ABBREVIATION [NCIT:C34882] +synonym: "rheumatic carditis" EXACT [DOID:0050827] +xref: DOID:0050827 {source="MONDO:equivalentTo"} +xref: EFO:1001161 {source="MONDO:equivalentTo"} +xref: ICD9:398.90 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:398.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10062110 {source="EFO:1001161"} +xref: MESH:D012214 {source="MONDO:equivalentTo", source="EFO:1001161"} +xref: NCIT:C34882 {source="MONDO:equivalentTo", source="EFO:1001161"} +xref: SCTID:23685000 {source="MONDO:equivalentTo", source="EFO:1001161"} +is_a: MONDO:0005267 ! heart disorder +is_a: MONDO:0021166 ! inflammatory disease +relationship: disease_has_inflammation_site UBERON:0000948 ! heart +property_value: closeMatch http://identifiers.org/meddra/10062110 +property_value: exactMatch DOID:0050827 +property_value: exactMatch http://identifiers.org/mesh/D012214 +property_value: exactMatch http://identifiers.org/snomedct/23685000 +property_value: exactMatch NCIT:C34882 +property_value: excluded_subClassOf MONDO:0002869 {source="DOID:0050827"} + +[Term] +id: MONDO:0006962 +name: sebaceous adenocarcinoma +def: "An adenocarcinoma with sebaceous differentiation. It presents as a painless mass and it may be multifocal. It grows in the ocular adnexae and in the skin of head and neck, trunk, genitals, and extremities. It is characterized by the presence of malignant cells with multivesicular and clear cytoplasm. It may recur and metastasize." [NCIT:C40310] +synonym: "adenocarcinoma of the sebaceous gland" EXACT [DOID:4839, NCIT:C3767] +synonym: "adenocarcinoma, sebaceous, malignant" EXACT [NCIT:C40310] +synonym: "carcinoma of sebaceous gland" EXACT [NCIT:C40310] +synonym: "carcinoma of the sebaceous gland" EXACT [NCIT:C40310] +synonym: "malignant sebaceous tumor" NARROW [DOID:4840, NCIT:C8409] +synonym: "Seba" RELATED [ONCOTREE:SEBA] +synonym: "sebaceous cancer" EXACT [NCIT:C40310] +synonym: "sebaceous carcinoma" EXACT [DOID:4839, MONDO:0003160, NCIT:C40310] +synonym: "sebaceous gland adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "sebaceous gland carcinoma" EXACT [NCIT:C40310] +xref: DOID:4839 {source="MONDO:equivalentTo", source="EFO:1001171"} +xref: DOID:4840 {source="MONDO:equivalentTo"} +xref: EFO:1001171 {source="MONDO:equivalentTo"} +xref: ICDO:8410/3 {source="NCIT:C40310"} +xref: MESH:D018266 {source="MONDO:equivalentTo", source="DOID:4839", source="EFO:1001171"} +xref: NCIT:C40310 {source="MONDO:equivalentTo", source="DOID:4839"} +xref: NCIT:C8409 {source="DOID:4840", source="MONDO:directSiblingOf"} +xref: ONCOTREE:SEBA {source="MONDO:equivalentTo"} +xref: SCTID:307599002 {source="MONDO:equivalentTo", source="DOID:4839"} +xref: UMLS:C0206684 {source="MONDO:equivalentTo", source="DOID:4839", source="NCIT:C40310"} +xref: UMLS:C1382026 {source="DOID:4840", source="MONDO:directSiblingOf"} +is_a: MONDO:0004970 {source="EFO:1001171", source="MESH:D018266", source="MONDO:Redundant", source="NCIT:C40310"} ! adenocarcinoma +is_a: MONDO:0006973 {source="MONDO:Redundant", source="NCIT:C40310"} ! skin appendage carcinoma +is_a: MONDO:0037735 ! sebaceous gland cancer +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0001821 ! sebaceous gland +property_value: exactMatch DOID:4839 +property_value: exactMatch DOID:4840 +property_value: exactMatch http://identifiers.org/mesh/D018266 +property_value: exactMatch http://identifiers.org/snomedct/307599002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206684 +property_value: exactMatch NCIT:C40310 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0006963 +name: sebaceous gland neoplasm +def: "A benign or malignant neoplasm that arises from the sebaceous glands. Representative examples include sebaceous adenoma and sebaceous carcinoma." [NCIT:C3363] +synonym: "neoplasm of sebaceous gland" EXACT [MONDO:patterns/neoplasm] +synonym: "sebaceous gland neoplasm" EXACT [NCIT:C3363] +synonym: "sebaceous gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sebaceous gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3363] +synonym: "sebaceous neoplasm" EXACT [DOID:5759, NCIT:C3363] +synonym: "sebaceous tumor" EXACT [NCIT:C3363] +synonym: "tumor of sebaceous gland" EXACT [MONDO:patterns/neoplasm] +xref: DOID:5759 {source="MONDO:equivalentTo", source="EFO:1001172"} +xref: EFO:1001172 {source="MONDO:equivalentTo"} +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012626 {source="MONDO:equivalentTo", source="DOID:5759", source="EFO:1001172"} +xref: NCIT:C3363 {source="MONDO:equivalentTo", source="DOID:5759", source="MONDO:exact-label-match", source="EFO:1001172"} +xref: SCTID:126491004 {source="MONDO:equivalentTo", source="DOID:5759"} +xref: UMLS:C0036503 {source="NCIT:C3363", source="MONDO:equivalentTo", source="DOID:5759"} +xref: UMLS:C3805742 {source="MONDO:equivalentTo"} +is_a: MONDO:0002297 {source="MONDO:Redundant", source="NCIT:C3363"} ! epidermal appendage tumor +is_a: MONDO:0006607 {source="MESH:D012626", source="MONDO:Redundant"} ! sebaceous gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001821 ! sebaceous gland +property_value: exactMatch DOID:5759 +property_value: exactMatch http://identifiers.org/mesh/D012626 +property_value: exactMatch http://identifiers.org/snomedct/126491004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0036503 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3805742 +property_value: exactMatch NCIT:C3363 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006969 +name: sialadenitis +def: "Sialadenitis is an infection of the salivary glands. It is usually caused by a virus or bacteria. The parotid (in front ofthe ear) and submandibular (under the chin) glands are most commonly affected. Sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. Sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. Diagnosis is usually made by clinical exam but a CT scan, MRI scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. Treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. Most salivary gland infections go away on their own or are cured with treatment. Complications are not common." [https://rarediseases.info.nih.gov/diseases/7638/sialadenitis] +comment: Editor note: TODO check NCIT mapping +subset: gard_rare {source="GARD:0007638"} +synonym: "adenitis, salivary gland" RELATED [GARD:0007638] +synonym: "lymphadenitis (disease) of saliva-secreting gland" EXACT [] +synonym: "saliva-secreting gland lymphadenitis (disease)" EXACT [MONDO:patterns/location] +synonym: "salivary gland inflammation" RELATED [GARD:0007638] +synonym: "sialitis" EXACT [NCIT:C115165] +synonym: "sialoadenitis" EXACT [DOID:10303] +xref: DOID:10303 {source="MONDO:equivalentTo", source="EFO:1001179"} +xref: EFO:1001179 {source="MONDO:equivalentTo"} +xref: GARD:0007638 {source="MONDO:equivalentTo"} +xref: ICD9:527.2 {source="DOID:10303", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10040627 {source="EFO:1001179"} +xref: MESH:D012793 {source="DOID:10303", source="MONDO:equivalentTo", source="EFO:1001179"} +xref: NCIT:C115165 {source="DOID:10303", source="MONDO:equivalentTo"} +xref: SCTID:42982001 {source="DOID:10303", source="MONDO:equivalentTo", source="EFO:1001179"} +xref: UMLS:C0037023 {source="DOID:10303", source="MONDO:equivalentTo"} +is_a: MONDO:0001142 {source="DOID:10303", source="EFO:1001179", source="MESH:D012793", source="MONDO:Redundant", source="NCIT:C115165/inferred"} ! salivary gland disorder +is_a: MONDO:0002052 {source="DOID:10303", source="MONDO:Entailed", source="MONDO:Redundant"} ! lymphadenitis +intersection_of: MONDO:0002052 ! lymphadenitis +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: closeMatch http://identifiers.org/meddra/10040627 +property_value: exactMatch DOID:10303 +property_value: exactMatch http://identifiers.org/mesh/D012793 +property_value: exactMatch http://identifiers.org/snomedct/42982001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037023 +property_value: exactMatch NCIT:C115165 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7638/sialadenitis xsd:anyURI {source="GARD:0007638"} + +[Term] +id: MONDO:0006971 +name: sigmoid neoplasm +def: "Tumors or cancer of the sigmoid colon." [MESH:D012811] +comment: Editor note: NCIT uses rectosigmoid as a region +synonym: "neoplasm of sigmoid colon" EXACT [MONDO:patterns/neoplasm] +synonym: "sigmoid colon neoplasm" EXACT [] +synonym: "sigmoid colon neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sigmoid colon tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of sigmoid colon" EXACT [MONDO:patterns/neoplasm] +xref: DOID:1896 {source="MONDO:equivalentTo", source="EFO:1001181"} +xref: EFO:1001181 {source="MONDO:equivalentTo"} +xref: ICD9:153.3 {source="EFO:1001181"} +xref: MedDRA:10026456 {source="EFO:1001181"} +xref: MESH:D012811 {source="DOID:1896", source="MONDO:equivalentTo", source="EFO:1001181"} +xref: SCTID:126845000 {source="DOID:1896", source="MONDO:equivalentTo", source="EFO:1001181"} +xref: UMLS:C0037073 {source="DOID:1896", source="MONDO:equivalentTo"} +is_a: MONDO:0005401 {source="EFO:1001181", source="MESH:D012811", source="MONDO:Entailed", source="MONDO:Redundant"} ! colonic neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001159 ! sigmoid colon +relationship: disease_has_location UBERON:0001159 ! sigmoid colon +property_value: closeMatch http://identifiers.org/meddra/10026456 +property_value: exactMatch DOID:1896 +property_value: exactMatch http://identifiers.org/mesh/D012811 +property_value: exactMatch http://identifiers.org/snomedct/126845000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037073 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0006973 +name: skin appendage carcinoma +def: "A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma." [NCIT:P378] +synonym: "adnexal carcinoma" EXACT [NCIT:C3775] +synonym: "carcinoma of adnexa" EXACT [NCIT:C3775] +synonym: "carcinoma of cutaneous appendage" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of skin appendage" EXACT [NCIT:C3775] +synonym: "carcinoma, adnexal, malignant" EXACT [NCIT:C3775] +synonym: "cutaneous appendage carcinoma" EXACT [MONDO:patterns/location] +synonym: "skin adnexal carcinoma" RELATED [ONCOTREE:SKAC] +synonym: "skin appendage carcinoma" EXACT [NCIT:C3775] +xref: EFO:1001183 {source="MONDO:equivalentTo"} +xref: ICDO:8390/3 {source="NCIT:C3775"} +xref: MedDRA:10040798 {source="EFO:1001183"} +xref: MESH:D018280 {source="MONDO:equivalentTo", source="EFO:1001183"} +xref: NCIT:C3775 {source="MONDO:equivalentTo", source="EFO:1001183"} +xref: ONCOTREE:SKAC {source="MONDO:equivalentTo"} +xref: UMLS:C0206697 {source="MONDO:equivalentTo", source="NCIT:C3775"} +is_a: MONDO:0002297 {source="MONDO:Redundant", source="NCIT:C3775/inferred"} ! epidermal appendage tumor +is_a: MONDO:0002656 {source="MONDO:Redundant", source="NCIT:C3775"} ! skin carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000021 ! cutaneous appendage +property_value: closeMatch http://identifiers.org/meddra/10040798 +property_value: exactMatch http://identifiers.org/mesh/D018280 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206697 +property_value: exactMatch NCIT:C3775 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0006975 +name: smooth muscle tumor +def: "A benign or malignant myomatous neoplasm arising from smooth muscle." [NCIT:C3751] +synonym: "neoplasm of smooth muscle" EXACT [NCIT:C3751] +synonym: "neoplasm of the smooth muscle" EXACT [NCIT:C3751] +synonym: "smooth muscle neoplasm" EXACT [NCIT:C3751] +synonym: "smooth muscle tumor" EXACT [NCIT:C3751] +synonym: "tumor of smooth muscle" EXACT [NCIT:C3751] +synonym: "tumor of the smooth muscle" EXACT [NCIT:C3751] +xref: DOID:4310 {source="EFO:1001185", source="MONDO:equivalentTo"} +xref: EFO:1001185 {source="MONDO:equivalentTo"} +xref: MESH:D018235 {source="DOID:4310", source="EFO:1001185", source="MONDO:equivalentTo"} +xref: NCIT:C3751 {source="DOID:4310", source="EFO:1001185", source="MONDO:equivalentTo"} +xref: UMLS:C0206658 {source="DOID:4310", source="MONDO:equivalentTo", source="NCIT:C3751"} +is_a: MONDO:0021545 {source="MESH:D018235", source="MONDO:Redundant", source="NCIT:C3751"} ! myomatous neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000192 ! smooth muscle cell +relationship: disease_arises_from_structure CL:0000192 {source="NCIT:C3751"} ! smooth muscle cell +property_value: exactMatch DOID:4310 +property_value: exactMatch http://identifiers.org/mesh/D018235 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206658 +property_value: exactMatch NCIT:C3751 + +[Term] +id: MONDO:0006998 +name: tonsil cancer +def: "A primary or metastatic malignant neoplasm that affects the tonsil." [NCIT:C7404] +synonym: "cancer of tonsil" BROAD [MONDO:patterns/cancer] +synonym: "malignant neoplasm of faucial tonsil" EXACT [DOID:8858] +synonym: "malignant neoplasm of palatine tonsil" EXACT [DOID:8858] +synonym: "malignant neoplasm of the tonsil" EXACT [NCIT:C7404] +synonym: "malignant neoplasm of tonsil" EXACT [MONDO:patterns/cancer, NCIT:C7404] +synonym: "malignant neoplasm of tonsil, faucial" EXACT [DOID:8858] +synonym: "malignant tonsil neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7404] +synonym: "malignant tonsil tumor" EXACT [NCIT:C7404] +synonym: "malignant tonsillar neoplasm" EXACT [NCIT:C7404] +synonym: "malignant tonsillar tumor" EXACT [DOID:8858, NCIT:C7404] +synonym: "malignant tumor of the tonsil" EXACT [NCIT:C7404] +synonym: "malignant tumor of tonsil" EXACT [NCIT:C7404] +synonym: "tonsil cancer" EXACT [MONDO:patterns/location] +xref: DOID:8858 {source="MONDO:equivalentTo", source="EFO:1001214"} +xref: EFO:1001214 {source="MONDO:equivalentTo"} +xref: ICD10CM:C09 {source="MONDO:equivalentTo", source="DOID:8858"} +xref: ICD9:146.0 {source="MONDO:equivalentTo", source="DOID:8858", source="MONDO:i2s"} +xref: MedDRA:10044002 {source="EFO:1001214"} +xref: MESH:D014067 {source="MONDO:equivalentTo", source="DOID:8858", source="EFO:1001214"} +xref: NCIT:C7404 {source="MONDO:equivalentTo", source="DOID:8858"} +xref: SCTID:363393007 {source="MONDO:equivalentTo", source="DOID:8858"} +xref: UMLS:C0751560 {source="MONDO:equivalentTo", source="DOID:8858", source="NCIT:C7404"} +is_a: MONDO:0004685 {source="MONDO:Redundant"} ! Waldeyer's ring cancer +is_a: MONDO:0021250 {source="MONDO:Redundant", source="NCIT:C7404"} ! tonsil neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002372 ! tonsil +property_value: closeMatch http://identifiers.org/meddra/10044002 +property_value: exactMatch DOID:8858 +property_value: exactMatch http://identifiers.org/mesh/D014067 +property_value: exactMatch http://identifiers.org/snomedct/363393007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751560 +property_value: exactMatch https://icd.codes/icd10cm/C09 +property_value: exactMatch NCIT:C7404 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0006999 +name: tooth disorder +def: "A disease involving the calcareous tooth." [https://orcid.org/0000-0002-6601-2165] +synonym: "calcareous tooth disease" EXACT [MONDO:patterns/location] +synonym: "calcareous tooth disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "dental disorder" EXACT [DOID:1091] +synonym: "disease of calcareous tooth" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of calcareous tooth" EXACT [] +synonym: "disorder of calcareous tooth" EXACT [MONDO:patterns/location_top] +synonym: "tooth disorder" EXACT [NCIT:C35077] +xref: DOID:1091 {source="MONDO:equivalentTo", source="EFO:1001216"} +xref: EFO:1001216 {source="MONDO:equivalentTo"} +xref: MESH:D014076 {source="MONDO:equivalentTo", source="DOID:1091"} +xref: NCIT:C35077 {source="MONDO:equivalentTo"} +xref: SCTID:234947003 {source="MONDO:equivalentTo", source="DOID:1091", source="EFO:1001216"} +xref: UMLS:C0040435 {source="NCIT:C35077", source="MONDO:equivalentTo", source="DOID:1091"} +is_a: MONDO:0005172 ! skeletal system disorder +is_a: MONDO:0006858 {source="DOID:1091", source="EFO:1001216", source="NCIT:C35077/inferred"} ! mouth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001091 ! calcareous tooth +relationship: disease_has_location UBERON:0001091 ! calcareous tooth +property_value: exactMatch DOID:1091 +property_value: exactMatch http://identifiers.org/mesh/D014076 +property_value: exactMatch http://identifiers.org/snomedct/234947003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040435 +property_value: exactMatch NCIT:C35077 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0007002 +name: trochlear nerve disorder +def: "A disease involving the trochlear nerve." [https://orcid.org/0000-0002-6601-2165] +synonym: "disease of trochlear nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of trochlear nerve" EXACT [] +synonym: "disorder of trochlear nerve" EXACT [DOID:13864, MONDO:patterns/location_top] +synonym: "IVth cranial nerve disorder" EXACT [NCIT:C78395] +synonym: "IVth nerve disorder" EXACT [NCIT:C78395] +synonym: "superior oblique muscle innervation disorder" EXACT [DOID:13864] +synonym: "trochlear nerve disease" EXACT [MONDO:patterns/location] +synonym: "trochlear nerve disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "trochlear nerve disorder" EXACT [NCIT:C78395] +xref: DOID:13864 {source="EFO:1001220", source="MONDO:equivalentTo"} +xref: EFO:1001220 {source="MONDO:equivalentTo"} +xref: ICD9:378.53 {source="MONDO:relatedTo", source="DOID:13864"} +xref: MedDRA:10074765 {source="EFO:1001220"} +xref: MESH:D020432 {source="EFO:1001220", source="MONDO:equivalentTo", source="DOID:13864"} +xref: NCIT:C78395 {source="MONDO:equivalentTo", source="DOID:13864"} +is_a: MONDO:0003569 {source="DOID:13864", source="MESH:D020432", source="MONDO:Redundant", source="NCIT:C78395"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001644 ! trochlear nerve +relationship: disease_has_location UBERON:0001644 ! trochlear nerve +property_value: closeMatch http://identifiers.org/meddra/10074765 +property_value: exactMatch DOID:13864 +property_value: exactMatch http://identifiers.org/mesh/D020432 +property_value: exactMatch NCIT:C78395 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0007004 +name: type III hypersensitivity disease +def: "Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa." [MESH:D007105] +synonym: "disorder of type III hypersensitivity" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "hypersensitivity reaction type III disease" RELATED [DOID:1557] +synonym: "immune complex disease" EXACT [DOID:1557] +synonym: "type 3 hypersensitivity reaction" EXACT [NCIT:C114346] +synonym: "type III hypersensitivity" EXACT [NCIT:C114346] +synonym: "type III hypersensitivity reaction" EXACT [NCIT:C114346] +xref: DOID:1557 {source="EFO:1001222", source="MONDO:equivalentTo"} +xref: EFO:1001222 {source="MONDO:equivalentTo"} +xref: MedDRA:10045265 {source="EFO:1001222"} +xref: MESH:D007105 {source="EFO:1001222", source="MONDO:equivalentTo", source="DOID:1557"} +xref: NCIT:C114346 {source="MONDO:equivalentTo"} +xref: UMLS:C0020951 {source="MONDO:equivalentTo", source="DOID:1557", source="NCIT:C114346"} +is_a: MONDO:0000605 {source="DOID:1557", source="EFO:1001222", source="MONDO:Entailed", source="NCIT:C114346"} ! hypersensitivity reaction disease +is_a: MONDO:0007179 ! autoimmune disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0001802 ! type III hypersensitivity +relationship: disease_has_basis_in_disruption_of GO:0001802 ! type III hypersensitivity +property_value: closeMatch http://identifiers.org/meddra/10045265 +property_value: exactMatch DOID:1557 +property_value: exactMatch http://identifiers.org/mesh/D007105 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020951 +property_value: exactMatch NCIT:C114346 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0007018 +name: vulvitis +def: "Inflammation of the vulva. It is characterized by pruritus and painful urination." [MESH:D014847] +synonym: "inflammation of mammalian vulva" EXACT [] +synonym: "mammalian vulva inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:3901 {source="MONDO:equivalentTo", source="EFO:1001239"} +xref: EFO:1001239 {source="MONDO:equivalentTo"} +xref: MedDRA:10047780 {source="EFO:1001239"} +xref: MESH:D014847 {source="MONDO:equivalentTo", source="EFO:1001239", source="DOID:3901"} +xref: SCTID:63144007 {source="MONDO:equivalentTo", source="EFO:1001239", source="DOID:3901"} +xref: UMLS:C0042996 {source="MONDO:equivalentTo", source="DOID:3901"} +is_a: MONDO:0002187 {source="DOID:3901", source="MESH:D014847"} ! vulvar disease +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000997 ! mammalian vulva +relationship: disease_has_inflammation_site UBERON:0000997 ! mammalian vulva +property_value: closeMatch http://identifiers.org/meddra/10047780 +property_value: exactMatch DOID:3901 +property_value: exactMatch http://identifiers.org/mesh/D014847 +property_value: exactMatch http://identifiers.org/snomedct/63144007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042996 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0007019 +name: vulvovaginitis +def: "An inflammatory pathologic process that affects the vulva and the vagina." [NCIT:P378] +synonym: "Vulvo-vaginitis" EXACT [DOID:2273] +xref: DOID:2273 {source="EFO:1001240", source="MONDO:equivalentTo"} +xref: EFO:1001240 {source="MONDO:equivalentTo"} +xref: MedDRA:10047794 {source="EFO:1001240"} +xref: MESH:D014848 {source="EFO:1001240", source="MONDO:equivalentTo", source="DOID:2273"} +xref: NCIT:C35131 {source="EFO:1001240", source="MONDO:equivalentTo", source="DOID:2273"} +xref: SCTID:53277000 {source="EFO:1001240", source="MONDO:equivalentTo", source="DOID:2273"} +xref: UMLS:C0042998 {source="NCIT:C35131", source="MONDO:equivalentTo", source="DOID:2273"} +is_a: MONDO:0002234 ! vaginitis +is_a: MONDO:0007018 {source="MESH:D014848", source="MONDO:Redundant"} ! vulvitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000996 ! vagina +intersection_of: disease_has_inflammation_site UBERON:0000997 ! mammalian vulva +property_value: closeMatch http://identifiers.org/meddra/10047794 +property_value: exactMatch DOID:2273 +property_value: exactMatch http://identifiers.org/mesh/D014848 +property_value: exactMatch http://identifiers.org/snomedct/53277000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042998 +property_value: exactMatch NCIT:C35131 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0007079 +name: alcohol dependence +def: "Physical and psychological dependence on alcohol." [NCIT:P378] +synonym: "Aerodigestive tract cancer, squamous cell, alcohol-related, protection against" RELATED [OMIM:103780] +synonym: "alcohol dependence" EXACT [OMIM:103780] +synonym: "alcohol dependence, protection against" RELATED [OMIM:103780] +synonym: "alcohol dependence, susceptibility to" EXACT [OMIM:103780, OMIM:genemap2] +synonym: "alcoholism" EXACT [DOID:0050741] +xref: DOID:0050741 {source="MONDO:equivalentTo", source="EFO:0003829"} +xref: EFO:0003829 {source="DOID:0050741", source="MONDO:equivalentTo"} +xref: ICD9:303.90 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:305.0 {source="EFO:0003829"} +xref: KEGG:05034 {source="MONDO:relatedTo", source="DOID:0050741"} +xref: NCIT:C93040 {source="MONDO:equivalentTo", source="EFO:0003829"} +xref: OMIM:103780 {source="DOID:0050741", source="MONDO:equivalentTo", source="EFO:0003829"} +xref: SCTID:66590003 {source="MONDO:equivalentTo", source="EFO:0003829"} +is_a: MONDO:0005303 {source="EFO:0003829"} ! drug dependence +is_a: MONDO:0021698 ! alcohol-related disorders +intersection_of: MONDO:0004938 ! substance dependence +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch DOID:0050741 +property_value: exactMatch http://identifiers.org/snomedct/66590003 +property_value: exactMatch https://omim.org/entry/103780 +property_value: exactMatch NCIT:C93040 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007108 +name: anal canal carcinoma +def: "A carcinoma that arises from epithelial cells of the anal canal" [https://orcid.org/0000-0002-6601-2165] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:424013"} +synonym: "anal canal and perianal gland cancer" EXACT [NCIT:C7489] +synonym: "anal canal and perianal gland carcinoma" EXACT [DOID:6126, NCIT:C7489] +synonym: "anal canal cancer" BROAD [NCIT:C7489] +synonym: "anal canal carcinoma" EXACT [MONDO:patterns/location, NCIT:C7489, OMIM:105580] +synonym: "carcinoma of anal canal" EXACT [DOID:6126, MONDO:patterns/carcinoma] +synonym: "carcinoma of the anal canal" EXACT [MONDO:0018517] +synonym: "cloacogenic carcinoma" RELATED [OMIM:105580] +xref: DOID:6126 {source="MONDO:equivalentTo"} +xref: NCIT:C7489 {source="DOID:6126", source="MONDO:equivalentTo"} +xref: OMIM:105580 {source="DOID:6126", source="MONDO:equivalentTo"} +xref: Orphanet:424013 {source="MONDO:equivalentTo"} +xref: SCTID:285310000 {source="DOID:6126", source="MONDO:equivalentTo"} +is_a: MONDO:0000405 {source="DOID:6126", source="MONDO:Entailed", source="MONDO:Redundant"} ! anal canal cancer +is_a: MONDO:0003199 {source="NCIT:C7489"} ! anal carcinoma +is_a: MONDO:0018516 {source="MONDO:Redundant", source="Orphanet:424013"} ! epithelial tumor of anal canal +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000159 ! anal canal +property_value: exactMatch DOID:6126 +property_value: exactMatch http://identifiers.org/snomedct/285310000 +property_value: exactMatch https://omim.org/entry/105580 +property_value: exactMatch NCIT:C7489 +property_value: exactMatch Orphanet:424013 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0007179 +name: autoimmune disease +def: "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)." [NCIT:C2889] +comment: Editor note: check OMIM +synonym: "autoimmune disease" EXACT [EFO:0005140, NCIT:C2889, OMIM:109100] +synonym: "autoimmune disease or disorder" EXACT [] +synonym: "autoimmune disorder" EXACT [NCIT:C2889] +synonym: "autoimmune hypersensitivity disease" RELATED [DOID:417] +synonym: "disease, autoimmune" EXACT [NCIT:C2889] +synonym: "hypersensitivity reaction type II disease" RELATED [DOID:417] +xref: DOID:417 {source="MONDO:equivalentTo"} +xref: EFO:0005140 {source="MONDO:equivalentTo"} +xref: ICD9:279.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:279.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:720 {source="DOID:417"} +xref: MESH:D001327 {source="MONDO:equivalentTo"} +xref: NCIT:C2889 {source="MONDO:equivalentTo", source="EFO:0005140"} +xref: OBI:1110054 {source="MONDO:equivalentTo", source="EFO:0005140"} +xref: OMIM:109100 {source="DOID:417", source="MONDO:equivalentTo"} +xref: SCTID:85828009 {source="MONDO:equivalentTo", source="EFO:0005140"} +xref: UMLS:C0004364 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="NCIT:C2889", source="OMIM:109100"} +is_a: MONDO:0005046 {source="DOID:417/inferred", source="EFO:0005140", source="MESH:D001327", source="MONDO:Redundant", source="NCIT:C2889"} ! immune system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +relationship: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:417 +property_value: exactMatch http://identifiers.org/mesh/D001327 +property_value: exactMatch http://identifiers.org/snomedct/85828009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004364 +property_value: exactMatch https://omim.org/entry/109100 +property_value: exactMatch NCIT:C2889 +property_value: excluded_subClassOf MONDO:0000605 {source="DOID:417", source="MONDO:Entailed"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0007182 +name: Machado-Joseph disease +def: "Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common subtype of type 1 autosomal dominant cerebellar ataxia (ADCA type 1), a neurodegenerative disorder, and is characterized by ataxia, external progressive ophthalmoplegia, and other neurological manifestations." [Orphanet:98757] +subset: ordo_disease {source="Orphanet:98757"} +synonym: "autosomal dominant striatonigral degeneration" EXACT [Orphanet:98757] +synonym: "Azorean disease" EXACT [DOID:1440] +synonym: "Azorean disease of the nervous system" EXACT [Orphanet:98757] +synonym: "Azorean neurologic disease" RELATED [OMIM:109150] +synonym: "Machado disease" EXACT [Orphanet:98757] +synonym: "Machado-Joseph disease" EXACT [MONDO:Lexical, OMIM:109150, Orphanet:98757] +synonym: "MJD" EXACT ABBREVIATION [DOID:1440, MONDO:Lexical, OMIM:109150, Orphanet:98757] +synonym: "Nigro-spino-dentatal degeneration with nuclear ophthalmoplegia" EXACT [Orphanet:98757] +synonym: "Nigrospinodentatal Degeneration" RELATED [OMIM:109150] +synonym: "SCA3" EXACT ABBREVIATION [Orphanet:98757] +synonym: "spinocerebellar ataxia 3" EXACT [DOID:1440, OMIM:109150] +synonym: "spinocerebellar ataxia type 3" EXACT [DOID:1440] +synonym: "spinocerebellar atrophy 3" RELATED [OMIM:109150] +synonym: "spinocerebellar atrophy type 3" RELATED [GARD:0006801] +synonym: "Spinopontine atrophy" RELATED [OMIM:109150] +xref: DOID:1440 {source="MONDO:equivalentTo"} +xref: GARD:0006801 {source="MONDO:equivalentTo"} +xref: ICD10CM:G11.8 {source="Orphanet:98757", source="Orphanet:98757/attributed", source="Orphanet:98757/ntbt"} +xref: ICD9:336.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D017827 {source="DOID:1440", source="MONDO:equivalentTo"} +xref: NCIT:C84830 {source="DOID:1440", source="MONDO:equivalentTo"} +xref: OMIM:109150 {source="DOID:1440", source="MONDO:equivalentTo", source="Orphanet:98757", source="Orphanet:98757/e"} +xref: Orphanet:98757 {source="MONDO:equivalentTo", source="OMIM:109150"} +xref: SCTID:91952008 {source="DOID:1440", source="MONDO:equivalentTo"} +xref: UMLS:C0024408 {source="DOID:1440", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="Orphanet:98757", source="OMIM:109150", source="NCIT:C84830"} +is_a: MONDO:0015548 {source="Orphanet:98757"} ! Huntington disease-like syndrome +is_a: MONDO:0019792 {source="Orphanet:98757"} ! autosomal dominant cerebellar ataxia type I +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/7106 {source="MONDO:mim2gene_medgen"} ! ATXN3 +property_value: exactMatch DOID:1440 +property_value: exactMatch http://identifiers.org/mesh/D017827 +property_value: exactMatch http://identifiers.org/snomedct/91952008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024408 +property_value: exactMatch https://omim.org/entry/109150 +property_value: exactMatch NCIT:C84830 +property_value: exactMatch Orphanet:98757 +property_value: narrowMatch https://icd.codes/icd10cm/G11.8 + +[Term] +id: MONDO:0007254 +name: breast cancer +def: "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." [NCIT:C9335] +synonym: "breast cancer" EXACT [MONDO:patterns/location] +synonym: "breast tumor" BROAD [DOID:1612, NCIT:C2910] +synonym: "cancer of breast" EXACT [MONDO:patterns/cancer] +synonym: "malignant breast neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9335] +synonym: "malignant breast tumor" EXACT [NCIT:C9335] +synonym: "malignant neoplasm of breast" EXACT [DOID:1612, MONDO:patterns/cancer, NCIT:C9335] +synonym: "malignant neoplasm of the breast" EXACT [NCIT:C9335] +synonym: "malignant tumor of breast" EXACT [NCIT:C9335] +synonym: "malignant tumor of the breast" EXACT [DOID:1612, NCIT:C9335] +synonym: "mammary cancer" EXACT [DOID:1612] +synonym: "mammary neoplasm" RELATED [DOID:1612] +synonym: "mammary tumor" BROAD [DOID:1612] +synonym: "primary breast cancer" NARROW [DOID:1612] +xref: DOID:1612 {source="MONDO:equivalentTo"} +xref: ICD10CM:C50 {source="MONDO:equivalentTo", source="DOID:1612"} +xref: ICD9:174.8 {source="DOID:1612"} +xref: NCIT:C9335 {source="MONDO:equivalentTo", source="DOID:1612"} +xref: SCTID:254837009 {source="MONDO:equivalentTo", source="DOID:1612"} +is_a: MONDO:0003274 {source="DOID:1612", source="MONDO:Redundant"} ! thoracic cancer +is_a: MONDO:0021100 {source="MONDO:Redundant", source="NCIT:C9335"} ! breast neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch DOID:1612 +property_value: exactMatch http://identifiers.org/snomedct/254837009 +property_value: exactMatch https://icd.codes/icd10cm/C50 +property_value: exactMatch NCIT:C9335 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0007256 +name: hepatocellular carcinoma +def: "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." [NCIT:C3099] +subset: ordo_disease {source="Orphanet:88673"} +synonym: "adult hepatoma" NARROW [DOID:684, NCIT:C7956] +synonym: "adult primary hepatocellular carcinoma" NARROW [DOID:684] +synonym: "cancer, hepatocellular" EXACT [OMIM:114550] +synonym: "carcinoma of liver" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of liver cells" EXACT [NCIT:C3099] +synonym: "carcinoma of the liver cells" EXACT [NCIT:C3099] +synonym: "carcinoma, hepatocellular, malignant" EXACT [NCIT:C3099] +synonym: "HCC" EXACT ABBREVIATION [DOID:684, NCIT:C3099, OMIM:114550, Orphanet:88673] +synonym: "hepatoblastoma" RELATED [OMIM:114550] +synonym: "hepatoblastoma caused by somatic mutation" RELATED [OMIM:114550] +synonym: "hepatoblastoma, somatic" EXACT [OMIM:114550, OMIM:genemap2] +synonym: "hepatocellular adenocarcinoma" EXACT [MONDO:design_patterns] +synonym: "hepatocellular cancer" EXACT [NCIT:C3099] +synonym: "hepatocellular cancer, somatic" EXACT [OMIM:114550, OMIM:genemap2] +synonym: "hepatocellular carcinoma" EXACT [NCIT:C3099, OMIM:114550] +synonym: "hepatocellular carcinoma, childhood type, somatic" EXACT [OMIM:114550, OMIM:genemap2] +synonym: "hepatocellular carcinoma, somatic" EXACT [OMIM:114550, OMIM:genemap2] +synonym: "hepatoma" EXACT [DOID:684, MONDO:cjm, NCIT:C3099, OMIM:114550] +synonym: "liver and intrahepatic bile duct carcinoma" RELATED [DOID:686, NCIT:C7927] +synonym: "liver cancer" RELATED [OMIM:114550] +synonym: "liver carcinoma" NARROW [MONDO:0004018, MONDO:patterns/location] +synonym: "liver cell cancer (hepatocellular carcinoma)" EXACT [NCIT:C3099] +synonym: "liver cell carcinoma" EXACT [NCIT:C3099, OMIM:114550] +synonym: "primary carcinoma of liver cells" EXACT [NCIT:C3099] +synonym: "primary carcinoma of the liver cells" EXACT [NCIT:C3099] +xref: DOID:684 {source="MONDO:equivalentTo", source="EFO:0000182"} +xref: DOID:686 {source="MONDO:equivalentTo"} +xref: EFO:0000182 {source="MONDO:equivalentTo", source="DOID:684"} +xref: ICDO:8170/3 {source="NCIT:C3099"} +xref: MedDRA:10049010 {source="Orphanet:88673/e", source="Orphanet:88673"} +xref: MESH:D006528 {source="Orphanet:88673/e", source="MONDO:equivalentTo", source="EFO:0000182", source="Orphanet:88673"} +xref: NCIT:C3099 {source="MONDO:equivalentTo", source="EFO:0000182"} +xref: OMIM:114550 {source="Orphanet:88673/e", source="MONDO:equivalentTo", source="DOID:684", source="EFO:0000182", source="Orphanet:88673"} +xref: ONCOTREE:HCC {source="MONDO:equivalentTo"} +xref: Orphanet:88673 {source="OMIM:114550", source="MONDO:equivalentTo"} +is_a: MONDO:0018532 ! adenocarcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure CL:0000182 ! hepatocyte +relationship: disease_arises_from_structure CL:0000182 {source="NCIT:C3099"} ! hepatocyte +property_value: closeMatch http://identifiers.org/meddra/10049010 +property_value: exactMatch DOID:684 +property_value: exactMatch DOID:686 +property_value: exactMatch http://identifiers.org/mesh/D006528 +property_value: exactMatch https://omim.org/entry/114550 +property_value: exactMatch NCIT:C3099 +property_value: exactMatch Orphanet:88673 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007462 +name: multiple sclerosis, susceptibility to +subset: predisposition +subset: prototype_pattern +synonym: "disseminated sclerosis" RELATED [OMIM:126200] +synonym: "MS" RELATED ABBREVIATION [OMIM:126200] +xref: OMIMPS:126200 {source="MONDO:cjm", source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005301 ! multiple sclerosis +relationship: predisposes_towards MONDO:0005301 ! multiple sclerosis +property_value: exactMatch https://omim.org/phenotypicSeries/PS126200 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0007576 +name: esophageal cancer +def: "A primary or metastatic malignant neoplasm involving the esophagus." [NCIT:C7478] +synonym: "Aerodigestive tract cancer, susceptibility to" RELATED [OMIM:133239] +synonym: "Ca lower third oesophagus" NARROW [DOID:5041] +synonym: "Ca middle third oesophagus" NARROW [DOID:5041] +synonym: "cancer of esophagus" EXACT [MONDO:patterns/cancer] +synonym: "Escc, susceptibility to" RELATED [OMIM:133239] +synonym: "esophageal cancer" EXACT [OMIM:133239] +synonym: "esophageal cancer, somatic" EXACT [OMIM:133239, OMIM:genemap2] +synonym: "esophageal carcinoma, somatic" EXACT [OMIM:133239, OMIM:genemap2] +synonym: "esophageal squamous cell carcinoma, somatic" EXACT [OMIM:133239, OMIM:genemap2] +synonym: "esophageal squamous cell carcinoma, susceptibility to" RELATED [OMIM:133239] +synonym: "esophagus cancer" EXACT [DOID:5041, MONDO:patterns/location] +synonym: "gastric cardia adenocarcinoma, susceptibility to" RELATED [OMIM:133239] +synonym: "malignant esophageal neoplasm" EXACT [NCIT:C7478] +synonym: "malignant esophageal tumor" EXACT [NCIT:C7478] +synonym: "malignant esophagus neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant esophagus tumor" EXACT [NCIT:C7478] +synonym: "malignant neoplasm of distal third of esophagus" NARROW [DOID:5041] +synonym: "malignant neoplasm of esophagus" EXACT [MONDO:patterns/cancer, NCIT:C7478] +synonym: "malignant neoplasm of lower third of oesophagus" NARROW [DOID:5041] +synonym: "malignant neoplasm of middle third of oesophagus" NARROW [DOID:5041] +synonym: "malignant neoplasm of proximal third of esophagus" NARROW [DOID:5041] +synonym: "malignant neoplasm of the esophagus" EXACT [NCIT:C7478] +synonym: "malignant neoplasm of upper third esophagus" NARROW [DOID:5041] +synonym: "malignant tumor of abdominal esophagus" NARROW [DOID:5041, NCIT:C4764] +synonym: "malignant tumor of distal third of esophagus" NARROW [DOID:5041, NCIT:C3535] +synonym: "malignant tumor of esophagus" EXACT [NCIT:C7478] +synonym: "malignant tumor of proximal third of esophagus" NARROW [DOID:5041, NCIT:C3533] +synonym: "malignant tumor of the esophagus" EXACT [NCIT:C7478] +synonym: "malignant tumor of the middle third of the esophagus" NARROW [DOID:5041, NCIT:C3534] +xref: DOID:5041 {source="MONDO:equivalentTo"} +xref: GARD:0006383 {source="MONDO:equivalentTo"} +xref: ICD9:150.2 {source="MONDO:relatedTo", source="DOID:5041"} +xref: ICD9:150.3 {source="DOID:5041"} +xref: ICD9:150.4 {source="DOID:5041"} +xref: ICD9:150.5 {source="DOID:5041"} +xref: ICD9:150.8 {source="MONDO:relatedTo", source="MONDO:i2s", source="DOID:5041"} +xref: ICD9:150.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C7478 {source="MONDO:equivalentTo"} +xref: OMIM:133239 {source="MONDO:equivalentTo", source="DOID:5041"} +xref: SCTID:363402007 {source="MONDO:equivalentTo"} +xref: UMLS:C0546837 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="NCIT:C7478"} +is_a: MONDO:0002516 {source="DOID:5041", source="MONDO:Redundant", source="NCIT:C7478"} ! digestive system cancer +is_a: MONDO:0003274 ! thoracic cancer +is_a: MONDO:0021355 {source="MONDO:Redundant", source="NCIT:C7478"} ! neoplasm of esophagus +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch DOID:5041 +property_value: exactMatch http://identifiers.org/snomedct/363402007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0546837 +property_value: exactMatch https://omim.org/entry/133239 +property_value: exactMatch NCIT:C7478 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007650 +name: MALT lymphoma +def: "An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)" [NCIT:C3898] +subset: ordo_disease {source="Orphanet:52417"} +synonym: "Extranodal marginal zone B-cell lymphoma" EXACT [Orphanet:52417] +synonym: "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue" EXACT [NCIT:C3898] +synonym: "Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)" EXACT [NCIT:C3898] +synonym: "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue" EXACT [NCIT:C3898] +synonym: "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)" RELATED [ONCOTREE:EMALT] +synonym: "familial primary gastric lymphoma" RELATED [GARD:0006485] +synonym: "gastric lymphoma, primary" RELATED [OMIM:137245] +synonym: "Immunocytoma" EXACT [NCIT:C3898] +synonym: "lymphoma of mucosa-associated lymphoid tissue" EXACT [MONDO:design_pattern] +synonym: "lymphoma, MALT, somatic" EXACT [OMIM:137245, OMIM:genemap2] +synonym: "lymphoma, mucosa-associated lymphoid type" RELATED [OMIM:137245] +synonym: "MALT lymphoma" EXACT [NCIT:C3898, OMIM:137245] +synonym: "MALT-lymphoma" EXACT [NCIT:C3898] +synonym: "MALToma" EXACT [NCIT:C3898, Orphanet:52417] +synonym: "mucosa-associated lymphatic tissue lymphoma" EXACT [Orphanet:52417] +synonym: "mucosa-associated lymphoid tissue lymphoma" EXACT [DOID:0050909, MONDO:patterns/location, NCIT:C3898, Orphanet:52417] +xref: DOID:0050909 {source="MONDO:equivalentTo", source="EFO:0000191"} +xref: EFO:0000191 {source="MONDO:equivalentTo"} +xref: GARD:0006485 {source="MONDO:equivalentTo"} +xref: ICD9:202.80 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:9699/3 {source="NCIT:C3898"} +xref: MedDRA:10060707 {source="Orphanet:52417", source="Orphanet:52417/e"} +xref: NCIT:C3898 {source="MONDO:equivalentTo", source="EFO:0000191"} +xref: OMIM:137245 {source="MONDO:equivalentTo", source="Orphanet:52417", source="Orphanet:52417/e"} +xref: ONCOTREE:EMALT {source="MONDO:equivalentTo"} +xref: Orphanet:52417 {source="MONDO:equivalentTo"} +xref: SCTID:277622004 {source="MONDO:equivalentTo"} +xref: UMLS:C0242647 {source="MONDO:equivalentTo", source="Orphanet:52417", source="NCIT:C3898"} +xref: UMLS:C1850900 {source="OMIM:137245", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline"} +xref: Wikipedia:MALT_lymphoma {source="EFO:0000191"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0004949 {source="EFO:0000191", source="NCIT:C3898/inferred", source="ONCOTREE:EMALT/inferred"} ! neoplasm of mature B-cells +is_a: MONDO:0017604 {source="NCIT:C3898", source="ONCOTREE:EMALT", source="Orphanet:52417"} ! marginal zone lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001961 ! mucosa-associated lymphoid tissue +relationship: disease_has_location UBERON:0001961 ! mucosa-associated lymphoid tissue +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/989 {source="MONDO:mim2gene_medgen"} ! BCL10 +property_value: closeMatch http://identifiers.org/meddra/10060707 +property_value: exactMatch DOID:0050909 +property_value: exactMatch http://identifiers.org/snomedct/277622004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0242647 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1850900 +property_value: exactMatch https://omim.org/entry/137245 +property_value: exactMatch NCIT:C3898 +property_value: exactMatch Orphanet:52417 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007739 +name: Huntington disease +def: "Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia." [Orphanet:399] +subset: ordo_disease {source="Orphanet:399"} +synonym: "HD" EXACT ABBREVIATION [DOID:12858, MONDO:Lexical, OMIM:143100] +synonym: "Huntington chorea" EXACT [OMIM:143100, Orphanet:399] +synonym: "Huntington disease" EXACT [DOID:12858, MONDO:Lexical, OMIM:143100] +synonym: "Huntington's chorea" EXACT [DOID:12858, ICD9CM:333.4] +synonym: "Huntington's disease" EXACT [doi:10.1093/jama/9780195176339.003.0016, MONDO:LexicalVariant] +xref: DOID:12858 {source="MONDO:equivalentTo"} +xref: GARD:0006677 {source="MONDO:equivalentTo"} +xref: ICD9:333.4 {source="DOID:12858", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: KEGG:05016 {source="MONDO:relatedTo", source="DOID:12858"} +xref: MedDRA:10070668 {source="Orphanet:399/e", source="Orphanet:399"} +xref: NCIT:C82342 {source="DOID:12858", source="MONDO:equivalentTo"} +xref: OMIM:143100 {source="DOID:12858", source="Orphanet:399/e", source="MONDO:equivalentTo", source="Orphanet:399"} +xref: Orphanet:399 {source="MONDO:equivalentTo", source="OMIM:143100"} +xref: SCTID:58756001 {source="DOID:12858", source="MONDO:equivalentTo"} +xref: UMLS:C0020179 {source="DOID:12858", source="Orphanet:399/e", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:143100", source="NCIT:C82342", source="Orphanet:399"} +is_a: MONDO:0000167 {source="MONDO:cjm"} ! Huntington disease and related disorders +is_a: MONDO:0005395 ! movement disorder +relationship: disease_has_feature HP:0000657 {source="https://orcid.org/0000-0002-2825-0621"} ! Oculomotor apraxia +relationship: disease_has_feature MONDO:0001627 {source="MONDO:Wikidata"} ! dementia +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/4851 {source="MONDO:mim2gene_medgen"} ! HTT +property_value: closeMatch http://identifiers.org/meddra/10070668 +property_value: exactMatch DOID:12858 +property_value: exactMatch http://identifiers.org/snomedct/58756001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020179 +property_value: exactMatch https://omim.org/entry/143100 +property_value: exactMatch NCIT:C82342 +property_value: exactMatch Orphanet:399 + +[Term] +id: MONDO:0007776 +name: hypersensitivity pneumonitis, familial +def: "An instance of hypersensitivity pneumonitis that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "hereditary hypersensitivity pneumonitis" EXACT [MONDO:patterns/hereditary] +synonym: "hypersensitivity pneumonitis, familial" EXACT [OMIM:145300] +xref: MESH:C536846 {source="MONDO:equivalentTo"} +xref: OMIM:145300 {source="MONDO:equivalentTo"} +xref: UMLS:C1840386 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:145300"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0017853 {source="MESH:C536846"} ! hypersensitivity pneumonitis +intersection_of: MONDO:0017853 ! hypersensitivity pneumonitis +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/C536846 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1840386 +property_value: exactMatch https://omim.org/entry/145300 + +[Term] +id: MONDO:0007781 +name: essential hypertension, genetic +def: "An instance of essential hypertension that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +synonym: "blood pressure regulation QTL" EXACT [OMIM:145500, OMIM:genemap2] +synonym: "Eht" RELATED [OMIM:145500] +synonym: "genetic essential hypertension" EXACT [MONDO:patterns/genetic] +synonym: "hypertension, essential" RELATED [OMIM:145500] +synonym: "hypertension, essential, salt-sensitive" EXACT [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to" EXACT [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 1" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 2" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 3" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 4" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 5" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, essential, susceptibility to, 6" NARROW [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, salt-sensitive essential, susceptibility to" EXACT [OMIM:145500, OMIM:genemap2] +synonym: "hypertension, susceptibility to" EXACT [OMIM:145500, OMIM:genemap2] +xref: OMIM:145500 {source="MONDO:equivalentTo"} +is_a: MONDO:0001134 ! essential hypertension +is_a: MONDO:0015512 ! genetic hypertension +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0001134 ! essential hypertension +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch https://omim.org/entry/145500 +property_value: excluded_subClassOf MONDO:0001134 {source="DC-OMIM:145500"} +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007848 +name: autosomal dominant keratitis +def: "Hereditary keratitis is characterised by opacification and vascularisation of the cornea, often associated with macula hypoplasia." [Orphanet:2334] +subset: ordo_disease {source="Orphanet:2334"} +synonym: "dominantly inherited keratitis" RELATED [GARD:0003089] +synonym: "hereditary keratitis" EXACT [Orphanet:2334] +synonym: "keratitis, autosomal dominant" EXACT [MONDO:patterns/autosomal_dominant] +synonym: "keratitis, hereditary" RELATED [OMIM:148190] +xref: DOID:0111383 {source="MONDO:equivalentTo"} +xref: GARD:0003089 {source="MONDO:equivalentTo"} +xref: ICD10CM:H16.8 {source="Orphanet:2334/attributed", source="Orphanet:2334/ntbt", source="Orphanet:2334"} +xref: MESH:C537022 {source="Orphanet:2334", source="MONDO:equivalentTo", source="Orphanet:2334/e"} +xref: OMIM:148190 {source="Orphanet:2334", source="MONDO:equivalentTo", source="Orphanet:2334/e"} +xref: Orphanet:2334 {source="MONDO:equivalentTo", source="OMIM:148190"} +xref: SCTID:715339004 {source="MONDO:equivalentTo"} +xref: UMLS:C1835698 {source="Orphanet:2334", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:148190", source="Orphanet:2334/e"} +xref: UMLS:C4017065 {source="MONDO:equivalentTo"} +xref: UMLS:CN068649 {source="MONDO:equivalentTo"} +is_a: MONDO:0000426 {source="MONDO:Redundant"} ! autosomal dominant disease +is_a: MONDO:0003085 {source="MESH:C537022", source="MONDO:Redundant"} ! keratitis +is_a: MONDO:0018102 {source="Orphanet:2334"} ! corneal dystrophy +intersection_of: MONDO:0003085 ! keratitis +intersection_of: has_modifier HP:0000006 ! Autosomal dominant inheritance +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/8620 {source="MONDO:mim2gene_medgen"} ! PAX6 +property_value: exactMatch DOID:0111383 +property_value: exactMatch http://identifiers.org/mesh/C537022 +property_value: exactMatch http://identifiers.org/snomedct/715339004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1835698 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4017065 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN068649 +property_value: exactMatch https://omim.org/entry/148190 +property_value: exactMatch Orphanet:2334 +property_value: narrowMatch https://icd.codes/icd10cm/H16.8 + +[Term] +id: MONDO:0007915 +name: systemic lupus erythematosus +def: "An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific." [NCIT:P378] +subset: ordo_disease +synonym: "disseminated lupus erythematosus" EXACT [DOID:9074] +synonym: "excess LMW-DNA" RELATED [OMIM:152700] +synonym: "excess lymphocyte low molecular weight DNA" RELATED [OMIM:152700] +synonym: "lupus erythematosus, systemic" EXACT [DOID:9074, MTH:U002054] +synonym: "lupus nephritis, susceptibility to" EXACT [OMIM:152700, OMIM:genemap2] +synonym: "SLE" EXACT ABBREVIATION [MONDO:Lexical, OMIM:152700] +synonym: "SLE - lupus erythematosus, systemic" EXACT [DOID:9074, NCIT:C3201] +synonym: "systemic lupus erythematosus" EXACT [MONDO:ambiguous, MONDO:Lexical, OMIM:152700] +synonym: "systemic lupus erythematosus (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "systemic lupus erythematosus susceptibility to" EXACT [OMIM:152700, OMIM:genemap2] +synonym: "systemic lupus erythematosus, susceptibility to" EXACT [OMIM:152700, OMIM:genemap2] +xref: DOID:9074 {source="MONDO:equivalentTo", source="EFO:0002690"} +xref: EFO:0002690 {source="DOID:9074", source="MONDO:equivalentTo"} +xref: HP:0002725 {source="MONDO:otherHierarchy"} +xref: ICD9:710.0 {source="DOID:9074", source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0002690"} +xref: KEGG:05322 {source="MONDO:relatedTo", source="DOID:9074"} +xref: MESH:D008180 {source="Orphanet:536", source="DOID:9074", source="MONDO:equivalentTo", source="EFO:0002690"} +xref: NCIT:C3201 {source="DOID:9074", source="MONDO:equivalentTo", source="EFO:0002690"} +xref: OMIM:152700 {source="DOID:9074", source="MONDO:equivalentTo", source="EFO:0002690", source="https://orcid.org/0000-0002-6601-2165"} +xref: Orphanet:536 {source="OMIM:152700", source="DOID:9074", source="MONDO:equivalentTo"} +xref: SCTID:55464009 {source="DOID:9074", source="MONDO:equivalentTo", source="EFO:0002690"} +is_a: MONDO:0004670 {source="DOID:9074", source="NCIT:C3201"} ! lupus erythematosus +is_a: MONDO:0019724 {source="Orphanet:536"} ! secondary glomerular disease +is_a: MONDO:0019737 {source="Orphanet:536"} ! thrombotic microangiopathy +property_value: exactMatch DOID:9074 +property_value: exactMatch http://identifiers.org/mesh/D008180 +property_value: exactMatch http://identifiers.org/snomedct/55464009 +property_value: exactMatch https://omim.org/entry/152700 +property_value: exactMatch NCIT:C3201 +property_value: exactMatch Orphanet:536 +property_value: IAO:0000589 "systemic lupus erythematosus (disease)" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007958 +name: familial medullary thyroid carcinoma +def: "An instance of thyroid medullary carcinoma that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: ordo_clinical_subtype {source="Orphanet:99361"} +synonym: "familial medullary thyroid carcinoma" EXACT [] +synonym: "familial MTC" EXACT [Orphanet:99361] +synonym: "Fmtc" RELATED [OMIM:155240] +synonym: "hereditary medullary thyroid gland carcinoma" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary thyroid medullary carcinoma" EXACT [MONDO:patterns/hereditary] +synonym: "medullary thyroid carcinoma" BROAD [OMIM:155240, OMIM:genemap2] +synonym: "MTC" RELATED ABBREVIATION [MONDO:Lexical, OMIM:155240] +synonym: "Mtc1" RELATED [OMIM:155240] +synonym: "thyroid carcinoma, familial medullary" EXACT [DOID:0050547, MONDO:Lexical, OMIM:155240] +xref: DOID:0050547 {source="MONDO:equivalentTo"} +xref: ICD10CM:C73 {source="Orphanet:99361/attributed", source="Orphanet:99361/ntbt", source="Orphanet:99361"} +xref: MESH:C536911 {source="Orphanet:99361/e", source="MONDO:equivalentTo", source="Orphanet:99361"} +xref: OMIM:155240 {source="Orphanet:99361/e", source="MONDO:equivalentTo", source="DOID:0050547", source="Orphanet:99361"} +xref: Orphanet:99361 {source="OMIM:155240", source="MONDO:equivalentTo"} +xref: UMLS:C1833921 {source="Orphanet:99361/e", source="OMIM:155240", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="Orphanet:99361"} +is_a: MONDO:0015277 {source="DOID:0050547", source="MONDO:Redundant"} ! medullary thyroid gland carcinoma +is_a: MONDO:0019003 {source="Orphanet:99361"} ! multiple endocrine neoplasia type 2 +is_a: MONDO:0025511 ! inherited neuroendocrine tumor +intersection_of: MONDO:0015277 ! medullary thyroid gland carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:0050547 +property_value: exactMatch http://identifiers.org/mesh/C536911 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1833921 +property_value: exactMatch https://omim.org/entry/155240 +property_value: exactMatch Orphanet:99361 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C73 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0007959 +name: medulloblastoma +def: "A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity." [NCIT:C3222] +subset: gard_rare {source="GARD:0007005"} +subset: ordo_disease {source="Orphanet:616"} +synonym: "brain medulloblastoma" EXACT [DOID:0050902] +synonym: "cerebellar medulloblastoma" RELATED [DOID:0060104] +synonym: "cerebellum embryonal neoplasm" EXACT [MONDO:patterns/location] +synonym: "CNS PNET" RELATED [DOID:0050902, NCIT:C5398] +synonym: "CPNET" RELATED ABBREVIATION [DOID:0050902] +synonym: "infratentorial primitive neuroectodermal tumor" RELATED [DOID:0050902] +synonym: "localized primitive neuroectodermal tumor" RELATED [DOID:0050902] +synonym: "MDB" RELATED ABBREVIATION [MONDO:Lexical, OMIM:155255] +synonym: "medulloblastoma" EXACT [MONDO:Lexical, NCIT:C3222, OMIM:155255] +synonym: "medulloblastoma with extensive nodularity" RELATED [OMIM:155255] +synonym: "medulloblastoma, autosomal recessive, autosomal dominant, somatic mutation" EXACT [OMIM:155255, OMIM:genemap2] +synonym: "medulloblastoma, Desmoplastic" RELATED [OMIM:155255] +synonym: "medulloblastoma, desmoplastic, autosomal recessive, autosomal dominant, somatic mutation" EXACT [OMIM:155255, OMIM:genemap2] +synonym: "medulloblastoma, malignant" EXACT [NCIT:C3222] +synonym: "medulloblastoma, somatic" EXACT [OMIM:155255, OMIM:genemap2] +synonym: "medulloblastomas" EXACT [NCIT:C3222] +xref: DOID:0050902 {source="EFO:0002939", source="MONDO:equivalentTo"} +xref: DOID:0060104 {source="MONDO:equivalentTo"} +xref: EFO:0002939 {source="MONDO:equivalentTo"} +xref: GARD:0007005 {source="MONDO:equivalentTo"} +xref: ICD10CM:C71.6 {source="Orphanet:616", source="Orphanet:616/ntbt"} +xref: ICDO:9470/3 {source="NCIT:C3222"} +xref: MedDRA:10027107 {source="Orphanet:616", source="Orphanet:616/e"} +xref: MESH:D008527 {source="EFO:0002939", source="MONDO:equivalentTo", source="Orphanet:616", source="DOID:0050902", source="Orphanet:616/e"} +xref: NCIT:C3222 {source="EFO:0002939", source="MONDO:equivalentTo", source="DOID:0050902"} +xref: OMIM:155255 {source="EFO:0002939", source="MONDO:equivalentTo", source="Orphanet:616", source="DOID:0050902", source="Orphanet:616/e"} +xref: ONCOTREE:MBL {source="MONDO:equivalentTo"} +xref: Orphanet:616 {source="MONDO:equivalentTo", source="OMIM:155255"} +xref: SCTID:443333004 {source="EFO:0002939", source="MONDO:equivalentTo", source="DOID:0050902"} +xref: UMLS:C0025149 {source="MONDO:equivalentTo", source="NCIT:C3222", source="Orphanet:616", source="MONDO:ncbi_mim2gene_medline", source="OMIM:155255", source="DOID:0050902", source="Orphanet:616/e"} +xref: UMLS:C1334410 {source="MONDO:equivalentTo", source="DOID:0050902"} +is_a: MONDO:0002913 {source="DOID:0060104", source="MONDO:Redundant", source="NCIT:C3222/inferred"} ! cerebellar neoplasm +is_a: MONDO:0016708 {source="Orphanet:616"} ! embryonal tumor of neuroepithelial tissue +intersection_of: MONDO:0005564 ! embryonal neoplasm +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: closeMatch http://identifiers.org/meddra/10027107 +property_value: exactMatch DOID:0050902 +property_value: exactMatch DOID:0060104 +property_value: exactMatch http://identifiers.org/mesh/D008527 +property_value: exactMatch http://identifiers.org/snomedct/443333004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025149 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334410 +property_value: exactMatch https://omim.org/entry/155255 +property_value: exactMatch NCIT:C3222 +property_value: exactMatch Orphanet:616 +property_value: narrowMatch https://icd.codes/icd10cm/C71.6 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7005/medulloblastoma xsd:anyURI {source="GARD:0007005"} + +[Term] +id: MONDO:0008162 +name: otitis media, susceptibility to +subset: predisposition +synonym: "come/Rom" RELATED [OMIM:166760] +synonym: "OMS" RELATED ABBREVIATION [OMIM:166760] +synonym: "otitis Media, chronic/recurrent" RELATED [OMIM:166760] +synonym: "otitis media, susceptibility to" EXACT [OMIM:166760] +xref: OMIM:166760 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005441 ! otitis media +relationship: predisposes_towards MONDO:0005441 ! otitis media +property_value: exactMatch https://omim.org/entry/166760 +property_value: http://purl.org/dc/terms/conformsTo inherited:susceptibility.yaml + +[Term] +id: MONDO:0008170 +name: ovarian cancer +def: "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." [NCIT:C7431] +synonym: "cancer of ovary" EXACT [MONDO:patterns/cancer, NCIT:C7431] +synonym: "cancer of the ovary" EXACT [NCIT:C7431] +synonym: "malignant neoplasm of ovary" EXACT [MONDO:patterns/cancer, NCIT:C7431] +synonym: "malignant neoplasm of the ovary" EXACT [NCIT:C7431] +synonym: "malignant ovarian neoplasm" EXACT [NCIT:C7431] +synonym: "malignant ovarian tumor" EXACT [DOID:2394, NCIT:C7431] +synonym: "malignant ovary neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of ovary" EXACT [NCIT:C7431] +synonym: "malignant tumor of the ovary" EXACT [NCIT:C7431] +synonym: "malignant tumour of ovary" EXACT [DOID:2394] +synonym: "ovarian cancer" EXACT [NCIT:C7431, OMIM:167000] +synonym: "ovarian cancer, epithelial" RELATED [OMIM:167000] +synonym: "ovarian cancer, somatic" EXACT [OMIM:167000, OMIM:genemap2] +synonym: "ovarian malignant tumor" EXACT [Orphanet:213500] +synonym: "ovarian neoplasm" BROAD [DOID:2394, MTH:NOCODE] +synonym: "ovary cancer" EXACT [MONDO:patterns/location] +synonym: "ovary neoplasm" BROAD [DOID:2394] +synonym: "primary ovarian cancer" RELATED [DOID:2394] +synonym: "tumor of the ovary" BROAD [DOID:2394, NCIT:C4984] +xref: DOID:2394 {source="MONDO:equivalentTo"} +xref: GARD:0007295 {source="MONDO:equivalentTo"} +xref: ICD9:183.0 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:2394"} +xref: MESH:D010051 {source="MONDO:equivalentTo", source="DOID:2394"} +xref: NCIT:C7431 {source="MONDO:equivalentTo", source="DOID:2394"} +xref: OMIM:167000 {source="MONDO:equivalentTo", source="DOID:2394"} +xref: Orphanet:213500 {source="MONDO:equivalentTo"} +xref: SCTID:363443007 {source="MONDO:equivalentTo", source="DOID:2394"} +is_a: MONDO:0001416 {source="DOID:2394", source="MONDO:Redundant", source="NCIT:C7431"} ! female reproductive organ cancer +is_a: MONDO:0021068 {source="MONDO:Redundant", source="NCIT:C7431"} ! ovarian neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:2394 +property_value: exactMatch http://identifiers.org/mesh/D010051 +property_value: exactMatch http://identifiers.org/snomedct/363443007 +property_value: exactMatch https://omim.org/entry/167000 +property_value: exactMatch NCIT:C7431 +property_value: exactMatch Orphanet:213500 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0008185 +name: hereditary chronic pancreatitis +def: "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas." [Orphanet:676] +subset: gard_rare +subset: ordo_disease {source="Orphanet:676"} +subset: predisposition +synonym: "autosomal dominant hereditary pancreatitis" RELATED [MESH:C537262] +synonym: "familial pancreatitis" RELATED [MESH:C537262] +synonym: "hereditary chronic pancreatitis" EXACT [GARD:0006632, MESH:C537262, MONDO:patterns/hereditary] +synonym: "hereditary pancreatitis" EXACT [NCIT:C95436] +synonym: "Hp" RELATED [MESH:C537262, OMIM:167800] +synonym: "HPC" RELATED ABBREVIATION [MESH:C537262, OMIM:167800] +synonym: "pancreatitis, calcific" RELATED [OMIM:167800] +synonym: "pancreatitis, calcific, included" RELATED [MESH:C537262] +synonym: "pancreatitis, chronic" RELATED [OMIM:167800] +synonym: "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included" RELATED [MESH:C537262] +synonym: "pancreatitis, chronic, protection against" RELATED [OMIM:167800] +synonym: "pancreatitis, chronic, protection against, included" RELATED [MESH:C537262] +synonym: "pancreatitis, chronic, susceptibility to" RELATED [OMIM:167800] +synonym: "pancreatitis, hereditary" RELATED [MESH:C537262, MONDO:Lexical, OMIM:167800] +synonym: "PCTT" RELATED ABBREVIATION [MESH:C537262, MONDO:Lexical, OMIM:167800] +xref: GARD:0006632 {source="MONDO:equivalentTo"} +xref: ICD10CM:K86.1 {source="Orphanet:676", source="Orphanet:676/attributed", source="Orphanet:676/ntbt"} +xref: ICD9:577.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:C537262 {source="MONDO:equivalentTo"} +xref: NCIT:C95436 {source="MONDO:equivalentTo"} +xref: OMIM:167800 {source="Orphanet:676", source="GARD:0006632", source="MONDO:equivalentTo", source="Orphanet:676/e"} +xref: Orphanet:676 {source="GARD:0006632", source="MONDO:equivalentTo", source="OMIM:167800"} +xref: SCTID:68072000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005003 {source="MESH:C537262", source="MONDO:Redundant"} ! chronic pancreatitis +is_a: MONDO:0005015 {source="MONDO:0015888-obsoleted", source="MONDO:Redundant", source="Orphanet:676"} ! diabetes mellitus +is_a: MONDO:0019052 ! inborn errors of metabolism +intersection_of: MONDO:0005003 ! chronic pancreatitis +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0015112", source="MONDO:0015618", source="MONDO:0015967"} ! rare +property_value: exactMatch http://identifiers.org/mesh/C537262 +property_value: exactMatch http://identifiers.org/snomedct/68072000 +property_value: exactMatch https://omim.org/entry/167800 +property_value: exactMatch NCIT:C95436 +property_value: exactMatch Orphanet:676 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: narrowMatch https://icd.codes/icd10cm/K86.1 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6632/hereditary-pancreatitis xsd:anyURI {source="GARD:0006632"} + +[Term] +id: MONDO:0008192 +name: paragangliomas 1 +def: "Any paraganglioma in which the cause of the disease is a mutation in the SDHD gene." [MONDO:patterns/disease_series_by_gene] +synonym: "carotid body tumors" RELATED [OMIM:168000] +synonym: "chemodectomas" RELATED [OMIM:168000] +synonym: "glomus jugulare tumors" RELATED [OMIM:168000] +synonym: "glomus tumors, familial, 1" RELATED [OMIM:168000] +synonym: "paraganglioma caused by mutation in SDHD" EXACT [MONDO:design_pattern] +synonym: "paraganglioma, carotid body" RELATED [OMIM:168000] +synonym: "paragangliomas 1" EXACT [MONDO:Lexical, OMIM:168000] +synonym: "paragangliomas 1, with or without deafness" EXACT [OMIM:168000, OMIM:genemap2] +synonym: "paragangliomas type 1" EXACT [MONDORULE:1, OMIM:168000] +synonym: "paragangliomas with sensorineural hearing loss" RELATED [OMIM:168000] +synonym: "paragangliomas, familial nonchromaffin, 1" RELATED [OMIM:168000] +synonym: "paragangliomas, familial, 1" RELATED [OMIM:168000] +synonym: "Paragangliomata" RELATED [OMIM:168000] +synonym: "PGL1" RELATED ABBREVIATION [MONDO:Lexical, OMIM:168000] +synonym: "SDHD paraganglioma" EXACT [MONDO:design_pattern, MONDO:patterns/disease_series_by_gene] +xref: GARD:0007324 {source="MONDO:equivalentTo"} +xref: OMIM:168000 {source="MONDO:equivalentTo"} +is_a: MONDO:0000448 {source="DC-OMIM:168000", source="MONDO:Redundant", source="OMIM:168000"} ! paraganglioma +is_a: MONDO:0017366 {source="Orphanet:29072/btnt"} ! hereditary pheochromocytoma-paraganglioma +is_a: MONDO:0021227 ! adrenal gland neoplasm +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/10683 ! SDHD +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/10683 {source="MONDO:mim2gene_medgen"} ! SDHD +property_value: exactMatch https://omim.org/entry/168000 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0008315 +name: prostate cancer +def: "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." [NCIT:C7378] +subset: ordo_disease {source="Orphanet:1331"} +synonym: "cancer of prostate gland" EXACT [MONDO:patterns/cancer] +synonym: "hereditary prostate cancer" NARROW [DOID:10283] +synonym: "malignant neoplasm of prostate" EXACT [NCIT:C7378] +synonym: "malignant neoplasm of prostate gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the prostate" EXACT [NCIT:C7378] +synonym: "malignant prostate gland neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant prostate neoplasm" EXACT [NCIT:C7378] +synonym: "malignant prostate tumor" EXACT [NCIT:C7378] +synonym: "malignant tumor of prostate" EXACT [NCIT:C7378] +synonym: "malignant tumor of the prostate" EXACT [DOID:10283, NCIT:C7378] +synonym: "NGP - new growth of prostate" EXACT [DOID:10283] +synonym: "prostate cancer" EXACT [OMIM:176807] +synonym: "prostate cancer, familial" EXACT [DOID:10283, MESH:C537243] +synonym: "prostate gland cancer" EXACT [MONDO:patterns/location] +synonym: "prostate neoplasm" BROAD [DOID:10283] +synonym: "prostatic cancer" EXACT [DOID:10283] +synonym: "prostatic neoplasm" BROAD [DOID:10283] +synonym: "tumor of the prostate" BROAD [DOID:10283, NCIT:C3343] +xref: DOID:10283 {source="MONDO:equivalentTo"} +xref: ICD10CM:C61 {source="Orphanet:1331/attributed", source="Orphanet:1331/ntbt", source="Orphanet:1331", source="DOID:10283"} +xref: ICD9:185 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10283"} +xref: MESH:D011471 {source="MONDO:equivalentTo", source="DOID:10283"} +xref: NCIT:C7378 {source="MONDO:equivalentTo", source="DOID:10283"} +xref: OMIM:300147 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:300704 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:601518 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:602759 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:603688 {source="Orphanet:1331/btnt", source="Orphanet:1331"} +xref: OMIM:608656 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:608658 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:609299 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:609558 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:610321 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:610997 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611100 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611868 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611928 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611955 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611958 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:611959 {source="Orphanet:1331/btnt", source="Orphanet:1331", source="DOID:10283"} +xref: OMIM:614731 {source="Orphanet:1331/btnt", source="Orphanet:1331"} +xref: SCTID:399068003 {source="MONDO:equivalentTo", source="DOID:10283"} +xref: UMLS:C0376358 {source="NCIT:C7378", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:176807", source="DOID:10283"} +is_a: MONDO:0005836 {source="DOID:10283", source="NCIT:C7378"} ! male reproductive organ cancer +is_a: MONDO:0021259 {source="MONDO:Redundant", source="NCIT:C7378"} ! prostate neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:10283 +property_value: exactMatch http://identifiers.org/mesh/D011471 +property_value: exactMatch http://identifiers.org/snomedct/399068003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376358 +property_value: exactMatch NCIT:C7378 +property_value: excluded_subClassOf MONDO:0017130 {source="Orphanet:1331"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C61 + +[Term] +id: MONDO:0008383 +name: rheumatoid arthritis +def: "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor." [NCIT:C2884] +synonym: "arthritis or polyarthritis, rheumatic" EXACT [DOID:7148] +synonym: "arthritis, rheumatoid" EXACT [NCIT:C2884] +synonym: "atrophic arthritis" EXACT [DOID:7148, NCIT:C27206] +synonym: "autoimmune arthritis" EXACT [] +synonym: "RA" EXACT ABBREVIATION [MONDO:Lexical, NCIT:C2884, OMIM:180300] +synonym: "rheumatoid arthritis" EXACT [MONDO:Lexical, NCIT:C2884, OMIM:180300] +synonym: "rheumatoid arthritis, progression of" EXACT [OMIM:180300, OMIM:genemap2] +synonym: "rheumatoid arthritis, susceptibility to" RELATED [OMIM:180300] +xref: DOID:7148 {source="MONDO:equivalentTo", source="EFO:0000685"} +xref: EFO:0000685 {source="DOID:7148", source="MONDO:equivalentTo"} +xref: ICD9:714.0 {source="DOID:7148", source="MONDO:equivalentTo", source="EFO:0000685", source="MONDO:i2s"} +xref: KEGG:05323 {source="DOID:7148", source="MONDO:relatedTo"} +xref: MESH:D001172 {source="DOID:7148", source="MONDO:equivalentTo", source="EFO:0000685"} +xref: NCIT:C2884 {source="DOID:7148", source="MONDO:equivalentTo", source="EFO:0000685"} +xref: OMIM:180300 {source="DOID:7148", source="MONDO:equivalentTo", source="EFO:0000685"} +xref: Orphanet:284130 {source="OMIM:180300", source="MONDO:equivalentTo"} +xref: SCTID:69896004 {source="DOID:7148", source="MONDO:equivalentTo", source="EFO:0000685"} +xref: UMLS:C0003873 {source="DOID:7148", source="OMIM:180300", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="NCIT:C2884"} +is_a: MONDO:0000589 ! autoimmune disorder of musculoskeletal system +is_a: MONDO:0005554 {source="EFO:0000685/inferred", source="MESH:D001172", source="MONDO:Redundant", source="NCIT:C2884"} ! rheumatic disorder +is_a: MONDO:0005578 {source="DOID:7148", source="EFO:0000685", source="MESH:D001172", source="MONDO:Redundant", source="NCIT:C2884"} ! arthritic joint disease +intersection_of: MONDO:0005578 ! arthritic joint disease +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +relationship: disease_has_feature HP:0001369 ! Arthritis +relationship: disease_has_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:7148 +property_value: exactMatch http://identifiers.org/mesh/D001172 +property_value: exactMatch http://identifiers.org/snomedct/69896004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003873 +property_value: exactMatch https://omim.org/entry/180300 +property_value: exactMatch NCIT:C2884 +property_value: exactMatch Orphanet:284130 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/mondo/qc-omim-subsumption.sparql +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0008599 +name: trigeminal neuralgia +def: "Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches." [https://rarediseases.info.nih.gov/diseases/7805/trigeminal-neuralgia] +subset: gard_rare {source="GARD:0007805"} +subset: ordo_disease {source="Orphanet:221091"} +synonym: "neuralgia of trigeminal nerve" EXACT [MONDO:design_pattern] +synonym: "Tic douloureux" RELATED [OMIM:190400] +synonym: "trifacial neuralgia" EXACT [DOID:12098] +synonym: "trifocal neuralgia" EXACT [DOID:12098] +synonym: "trigeminal nerve neuralgia" EXACT [MONDO:patterns/location] +synonym: "trigeminal neuralgia" EXACT [DOID:12098, ICD9CM:350.1, OMIM:190400] +xref: DOID:12098 {source="MONDO:equivalentTo", source="EFO:1001219"} +xref: EFO:1001219 {source="MONDO:equivalentTo"} +xref: GARD:0007805 {source="MONDO:equivalentTo"} +xref: ICD10CM:G50.0 {source="MONDO:equivalentTo", source="DOID:12098", source="Orphanet:221091", source="EFO:1001219", source="Orphanet:221091/e"} +xref: ICD9:350.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:12098"} +xref: MedDRA:10044652 {source="Orphanet:221091", source="EFO:1001219", source="Orphanet:221091/e"} +xref: MESH:D014277 {source="MONDO:equivalentTo", source="DOID:12098", source="Orphanet:221091", source="EFO:1001219", source="Orphanet:221091/e"} +xref: OMIM:190400 {source="MONDO:equivalentTo", source="DOID:12098", source="Orphanet:221091", source="EFO:1001219", source="Orphanet:221091/e"} +xref: Orphanet:221091 {source="OMIM:190400", source="MONDO:equivalentTo"} +xref: SCTID:31681005 {source="MONDO:equivalentTo", source="DOID:12098", source="EFO:1001219"} +xref: UMLS:C0040997 {source="OMIM:190400", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="DOID:12098", source="Orphanet:221091", source="Orphanet:221091/e"} +is_a: MONDO:0002602 {source="ISBN-13:978-1259644030"} ! central nervous system disorder +is_a: MONDO:0003543 {source="DOID:12098", source="MESH:D014277", source="MONDO:Redundant"} ! trigeminal nerve disorder +is_a: MONDO:0016374 {source="MONDO:Redundant", source="Orphanet:221091"} ! cranial neuralgia +intersection_of: MONDO:0021667 ! neuralgia +intersection_of: disease_has_location UBERON:0001645 ! trigeminal nerve +property_value: closeMatch http://identifiers.org/meddra/10044652 +property_value: exactMatch DOID:12098 +property_value: exactMatch http://identifiers.org/mesh/D014277 +property_value: exactMatch http://identifiers.org/snomedct/31681005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040997 +property_value: exactMatch https://icd.codes/icd10cm/G50.0 +property_value: exactMatch https://omim.org/entry/190400 +property_value: exactMatch Orphanet:221091 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7805/trigeminal-neuralgia xsd:anyURI {source="GARD:0007805"} + +[Term] +id: MONDO:0008627 +name: ureter cancer +def: "A malignant neoplasm involving the ureter" [https://orcid.org/0000-0002-6601-2165] +synonym: "cancer of ureter" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the ureter" EXACT [NCIT:C7543] +synonym: "malignant neoplasm of ureter" EXACT [MONDO:patterns/cancer, NCIT:C7543] +synonym: "malignant tumor of the ureter" EXACT [NCIT:C7543] +synonym: "malignant tumor of ureter" EXACT [NCIT:C7543] +synonym: "malignant tumour of ureter" EXACT [DOID:11819] +synonym: "malignant ureter neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7543] +synonym: "malignant ureter tumor" EXACT [NCIT:C7543] +synonym: "malignant ureteral neoplasm" EXACT [NCIT:C7543] +synonym: "malignant ureteral tumor" EXACT [DOID:11819, NCIT:C7543] +synonym: "ureter cancer" EXACT [MONDO:patterns/location] +synonym: "ureter, cancer OF" RELATED [OMIM:191600] +xref: DOID:11819 {source="MONDO:equivalentTo"} +xref: ICD10CM:C66 {source="MONDO:equivalentTo", source="DOID:11819"} +xref: ICD9:189.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11819"} +xref: MESH:D014516 {source="MONDO:equivalentTo", source="DOID:11819"} +xref: NCIT:C7543 {source="MONDO:equivalentTo", source="DOID:11819"} +xref: OMIM:191600 {source="MONDO:equivalentTo", source="DOID:11819"} +xref: SCTID:363458004 {source="MONDO:equivalentTo", source="DOID:11819"} +xref: UMLS:C0153619 {source="NCIT:C7543", source="OMIM:191600", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="DOID:11819"} +is_a: MONDO:0006295 {source="DOID:11819", source="ICD10CM:C66", source="MONDO:Redundant", source="NCIT:C7543"} ! malignant urinary system neoplasm +is_a: MONDO:0021111 {source="MONDO:Redundant", source="NCIT:C7543"} ! ureter neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:11819 +property_value: exactMatch http://identifiers.org/mesh/D014516 +property_value: exactMatch http://identifiers.org/snomedct/363458004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153619 +property_value: exactMatch https://icd.codes/icd10cm/C66 +property_value: exactMatch https://omim.org/entry/191600 +property_value: exactMatch NCIT:C7543 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0008640 +name: vasculitis, lymphocytic, nodular +def: "Lymphocytic vasculitis is one of several skin conditions which are collectively referred to as cutaneous vasculitis. In lymphocytic vasculitis, white blood cells (lymphocytes) cause damage to blood vessels in the skin. This condition is thought to be caused by a number of factors, but the exact cause of most cases is not known. This disease can present with a variety of symptoms, depending on the size, location, and severity of the affected area. In a minority of patients, cutaneous vasculitis can be part of a more severe vasculitis affecting other organs in the body - this is known as systemic vasculitis." [GARD:0006941] +subset: gard_rare +synonym: "lymphocytic vasculitis" RELATED [GARD:0006941] +synonym: "vasculitis lymphocytic, nodular" RELATED [GARD:0006941] +synonym: "vasculitis, lymphocytic, nodular" EXACT [OMIM:192310] +xref: GARD:0006941 {source="MONDO:equivalentTo"} +xref: MESH:C566008 {source="MONDO:equivalentTo"} +xref: OMIM:192310 {source="GARD:0006941", source="MONDO:equivalentTo"} +xref: UMLS:C1860519 {source="GARD:0006941", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:192310"} +is_a: MONDO:0018882 ! vasculitis +is_a: MONDO:0024255 ! genetic skin disease +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_has_basis_in_dysfunction_of CL:0000542 ! lymphocyte +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +relationship: disease_has_basis_in_dysfunction_of CL:0000542 ! lymphocyte +property_value: exactMatch http://identifiers.org/mesh/C566008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1860519 +property_value: exactMatch https://omim.org/entry/192310 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6941/lymphocytic-vasculitis xsd:anyURI {source="GARD:0006941"} + +[Term] +id: MONDO:0008734 +name: adrenocortical carcinoma, hereditary +def: "An instance of adrenal cortex carcinoma that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "ADCC" RELATED ABBREVIATION [MONDO:Lexical, OMIM:202300] +synonym: "adrenocortical carcinoma, hereditary" EXACT [MONDO:Lexical, OMIM:202300] +synonym: "adrenocortical carcinoma, pediatric" RELATED [OMIM:202300] +synonym: "hereditary adrenal cortex carcinoma" EXACT [MONDO:patterns/hereditary] +xref: MESH:C565972 {source="MONDO:equivalentTo"} +xref: OMIM:202300 {source="MONDO:equivalentTo"} +xref: UMLS:C1859972 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:202300"} +is_a: MONDO:0003008 ! hereditary renal cell carcinoma +is_a: MONDO:0006639 {source="MONDO:Redundant", source="Orphanet:1501/btnt"} ! adrenal cortex carcinoma +intersection_of: MONDO:0006639 ! adrenal cortex carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 {source="MONDO:mim2gene_medgen"} ! TP53 +property_value: exactMatch http://identifiers.org/mesh/C565972 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1859972 +property_value: exactMatch https://omim.org/entry/202300 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml + +[Term] +id: MONDO:0008903 +name: lung cancer +def: "A malignant neoplasm involving the lung." [https://orcid.org/0000-0002-6601-2165] +synonym: "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "adenocarcinoma of lung, somatic" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "alveolar cell carcinoma" RELATED [OMIM:211980] +synonym: "cancer of lung" EXACT [MONDO:patterns/cancer] +synonym: "lung cancer" EXACT [MONDO:patterns/location] +synonym: "lung cancer, protection against" RELATED [OMIM:211980] +synonym: "lung cancer, protection against, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "lung cancer, resistance to, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "lung cancer, somatic" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "lung cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "lung neoplasm" RELATED [DOID:1324] +synonym: "malignant lung neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant lung tumor" EXACT [NCIT:C7377] +synonym: "malignant neoplasm of lung" EXACT [MONDO:patterns/cancer, NCIT:C7377] +synonym: "malignant neoplasm of the lung" EXACT [NCIT:C7377] +synonym: "malignant tumor of lung" EXACT [NCIT:C7377] +synonym: "malignant tumor of the lung" EXACT [NCIT:C7377] +synonym: "Nonsmall cell lung cancer" RELATED [OMIM:211980] +synonym: "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "nonsmall cell lung cancer, somatic" EXACT [OMIM:211980, OMIM:genemap2] +synonym: "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:211980, OMIM:genemap2] +xref: DOID:1324 {source="MONDO:equivalentTo"} +xref: ICD9:162.3 {source="DOID:1324"} +xref: ICD9:162.4 {source="DOID:1324"} +xref: ICD9:162.5 {source="DOID:1324"} +xref: ICD9:162.8 {source="MONDO:relatedTo", source="DOID:1324", source="MONDO:i2s"} +xref: ICD9:162.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C7377 {source="MONDO:equivalentTo"} +xref: OMIM:211980 {source="DOID:1324", source="MONDO:equivalentTo"} +xref: SCTID:363358000 {source="MONDO:equivalentTo"} +is_a: MONDO:0000376 {source="DOID:1324", source="MONDO:Redundant"} ! respiratory system cancer +is_a: MONDO:0003274 {source="MONDO:Redundant", source="NCIT:C7377"} ! thoracic cancer +is_a: MONDO:0021117 {source="MONDO:Redundant", source="NCIT:C7377"} ! lung neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002048 ! lung +relationship: disease_has_feature HP:0012735 {source="MONDO:Wikidata"} ! Cough +relationship: disease_has_feature HP:0030828 {source="MONDO:Wikidata"} ! Wheezing +property_value: exactMatch DOID:1324 +property_value: exactMatch http://identifiers.org/snomedct/363358000 +property_value: exactMatch https://omim.org/entry/211980 +property_value: exactMatch NCIT:C7377 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0009332 +name: congenital hematological disorder +def: "A disorder of the blood that is present at birth." [NCIT:C104003] +synonym: "congenital hematological disorder" EXACT [NCIT:C104003] +synonym: "congenital hematological system disease" EXACT [MONDO:patterns/congenital] +xref: NCIT:C104003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005570 ! hematologic disorder +intersection_of: MONDO:0005570 ! hematologic disorder +intersection_of: has_modifier MONDO:0021140 ! congenital +relationship: has_modifier MONDO:0021140 {source="https://orcid.org/0000-0002-4142-7153"} ! congenital +property_value: exactMatch NCIT:C104003 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0009453 +name: immune deficiency disease +synonym: "immune deficiency disease" EXACT [OMIM:242850] +xref: MESH:C565469 {source="MONDO:equivalentTo"} +xref: OMIM:242850 {source="MONDO:equivalentTo"} +xref: UMLS:C1855771 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:242850"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005046 {source="https://orcid.org/0000-0001-5208-3432"} ! immune system disorder +property_value: exactMatch http://identifiers.org/mesh/C565469 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1855771 +property_value: exactMatch https://omim.org/entry/242850 +property_value: excluded_subClassOf MONDO:0003778 {source="DC-OMIM:242850", source="MESH:C565469"} + +[Term] +id: MONDO:0009637 +name: inborn mitochondrial myopathy +def: "Myopathy caused by mitochondrial abnormalities." [NCIT:C101328] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:206966"} +synonym: "mitochondrial cytopathy" EXACT [DOID:699] +synonym: "mitochondrial myopathy" EXACT [NCIT:C101328, OMIM:251900] +xref: DOID:699 {source="MONDO:equivalentTo"} +xref: GARD:0011956 {source="MONDO:equivalentTo"} +xref: ICD10CM:G71.3 {source="Orphanet:206966", source="Orphanet:206966/attributed", source="Orphanet:206966/ntbt"} +xref: MedDRA:10027710 {source="Orphanet:206966", source="Orphanet:206966/e"} +xref: MESH:D017240 {source="DOID:699", source="Orphanet:206966", source="MONDO:equivalentTo", source="Orphanet:206966/e"} +xref: NCIT:C101328 {source="DOID:699", source="MONDO:equivalentTo"} +xref: Orphanet:206966 {source="MONDO:equivalentTo"} +xref: UMLS:C0162670 {source="DOID:699", source="Orphanet:206966", source="OMIM:251900", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="Orphanet:206966/e", source="NCIT:C101328"} +is_a: MONDO:0002921 {source="NCIT:C101328"} ! congenital structural myopathy +is_a: MONDO:0004069 {source="MESH:D017240"} ! inborn mitochondrial metabolism disorder +intersection_of: MONDO:0004069 ! inborn mitochondrial metabolism disorder +intersection_of: MONDO:0005336 ! myopathy +property_value: closeMatch http://identifiers.org/meddra/10027710 +property_value: exactMatch DOID:699 +property_value: exactMatch http://identifiers.org/mesh/D017240 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0162670 +property_value: exactMatch NCIT:C101328 +property_value: exactMatch Orphanet:206966 +property_value: excluded_subClassOf MONDO:0016117 {source="Orphanet:206966"} +property_value: narrowMatch https://icd.codes/icd10cm/G71.3 + +[Term] +id: MONDO:0009693 +name: plasma cell myeloma +def: "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)" [NCIT:C3242] +subset: ordo_disease {source="Orphanet:29073"} +synonym: "Al amyloidosis" RELATED [OMIM:254500] +synonym: "amyloidosis, systemic" RELATED [OMIM:254500] +synonym: "Kahler disease" EXACT [NCIT:C3242] +synonym: "Kahler's disease" EXACT [Orphanet:29073] +synonym: "medullary plasmacytoma" EXACT [Orphanet:29073] +synonym: "multiple myeloma" EXACT [NCIT:C3242] +synonym: "multiple myeloma, resistance to, Somatic mutation" EXACT [OMIM:254500, OMIM:genemap2] +synonym: "multiple myeloma, susceptibility to, Somatic mutation" EXACT [OMIM:254500, OMIM:genemap2] +synonym: "multiple myeloma/plasma cell myeloma" EXACT [NCIT:C3242] +synonym: "myeloid neoplasm of plasma cell" EXACT [MONDO:design_pattern] +synonym: "myeloma" EXACT [NCIT:C3242] +synonym: "myeloma - multiple" RELATED [GARD:0007108] +synonym: "myeloma, multiple" EXACT [OMIM:254500] +synonym: "myeloma, plasma cell, malignant" EXACT [NCIT:C3242] +synonym: "myelomatosis" EXACT [NCIT:C3242, Orphanet:29073] +synonym: "plasma cell myeloid neoplasm" EXACT [MONDO:patterns/location] +synonym: "plasma cell myeloma" EXACT [DOID:9538, NCIT:C3242, Orphanet:29073] +xref: DOID:9538 {source="MONDO:equivalentTo", source="EFO:0001378"} +xref: EFO:0001378 {source="DOID:9538", source="MONDO:equivalentTo"} +xref: GARD:0007108 {source="MONDO:equivalentTo"} +xref: ICD10CM:C90.0 {source="Orphanet:29073", source="DOID:9538", source="MONDO:equivalentTo", source="Orphanet:29073/e"} +xref: ICD9:203.0 {source="DOID:9538", source="EFO:0001378"} +xref: ICDO:9732/3 {source="NCIT:C3242"} +xref: MedDRA:10028228 {source="Orphanet:29073", source="Orphanet:29073/e"} +xref: MESH:D009101 {source="Orphanet:29073", source="DOID:9538", source="MONDO:equivalentTo", source="Orphanet:29073/e", source="EFO:0001378"} +xref: NCIT:C3242 {source="DOID:9538", source="MONDO:equivalentTo", source="EFO:0001378"} +xref: OMIM:254500 {source="Orphanet:29073", source="DOID:9538", source="MONDO:equivalentTo", source="Orphanet:29073/e"} +xref: ONCOTREE:PCM {source="MONDO:equivalentTo"} +xref: Orphanet:29073 {source="MONDO:equivalentTo", source="OMIM:254500"} +xref: UMLS:C0026764 {source="Orphanet:29073", source="NCIT:C3242", source="DOID:9538", source="MONDO:equivalentTo", source="Orphanet:29073/e", source="MONDO:ncbi_mim2gene_medline", source="OMIM:254500"} +is_a: MONDO:0000621 ! immune system cancer +is_a: MONDO:0004959 {source="EFO:0001378", source="MESH:D009101", source="NCIT:C3242", source="Orphanet:29073"} ! plasma cell neoplasm +is_a: MONDO:0005170 {source="DOID:9538", source="MONDO:Entailed", source="MONDO:Redundant"} ! myeloid neoplasm +intersection_of: MONDO:0005170 ! myeloid neoplasm +intersection_of: disease_has_location CL:0000786 ! plasma cell +relationship: disease_has_location CL:0000786 ! plasma cell +property_value: closeMatch http://identifiers.org/meddra/10028228 +property_value: exactMatch DOID:9538 +property_value: exactMatch http://identifiers.org/mesh/D009101 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026764 +property_value: exactMatch https://icd.codes/icd10cm/C90.0 +property_value: exactMatch https://omim.org/entry/254500 +property_value: exactMatch NCIT:C3242 +property_value: exactMatch Orphanet:29073 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/1506 xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0009825 +name: 5-oxoprolinase deficiency +def: "5-Oxoprolinase deficiency is clinically a very heterogeneous condition characterized by 5-oxoprolinuria." [Orphanet:33572] +subset: ordo_disease {source="Orphanet:33572"} +synonym: "5-alpha-oxoprolinase deficiency" RELATED [GARD:0005681] +synonym: "5-oxoprolinase deficiency" EXACT [MONDO:ambiguous, MONDO:Lexical, OMIM:260005] +synonym: "5-oxoprolinase deficiency (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "inborn 5-oxoprolinase (ATP-hydrolyzing) activity disorder" EXACT [] +synonym: "inborn error of 5-oxoprolinase (ATP-hydrolyzing) activity" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "OPLAHD" RELATED ABBREVIATION [MONDO:Lexical, OMIM:260005] +synonym: "oxoprolinuria due to 5-oxoprolinase deficiency" RELATED [OMIM:260005] +synonym: "oxoprolinuria due to oxoprolinase deficiency" EXACT [Orphanet:33572] +synonym: "rare inborn error of 5-oxoprolinase (ATP-hydrolyzing) activity" EXACT [MONDO:patterns/inborn_metabolic] +xref: GARD:0005681 {source="MONDO:equivalentTo"} +xref: HP:0040142 {source="MONDO:otherHierarchy"} +xref: ICD10CM:E72.8 {source="Orphanet:33572/attributed", source="Orphanet:33572/ntbt", source="Orphanet:33572"} +xref: ICD9:270.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:C535322 {source="Orphanet:33572/e", source="MONDO:equivalentTo", source="Orphanet:33572"} +xref: OMIM:260005 {source="Orphanet:33572/e", source="MONDO:equivalentTo", source="Orphanet:33572"} +xref: Orphanet:33572 {source="OMIM:260005", source="MONDO:equivalentTo"} +xref: SCTID:26132002 {source="MONDO:equivalentTo"} +xref: UMLS:C0268525 {source="OMIM:260005", source="Orphanet:33572/e", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="Orphanet:33572"} +is_a: MONDO:0040566 {source="PMID:33340416"} ! inherited glutathione metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0017168 ! 5-oxoprolinase (ATP-hydrolyzing) activity +relationship: disease_has_basis_in_disruption_of GO:0017168 ! 5-oxoprolinase (ATP-hydrolyzing) activity +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/8149 {source="MONDO:mim2gene_medgen"} ! OPLAH +property_value: exactMatch http://identifiers.org/mesh/C535322 +property_value: exactMatch http://identifiers.org/snomedct/26132002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268525 +property_value: exactMatch https://omim.org/entry/260005 +property_value: exactMatch Orphanet:33572 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: IAO:0000589 "5-oxoprolinase deficiency (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/E72.8 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4985 + +[Term] +id: MONDO:0009831 +name: malignant pancreatic neoplasm +def: "A malignant neoplasm involving the pancreas." [https://orcid.org/0000-0002-6601-2165] +synonym: "Ca body of pancreas" EXACT [DOID:1793] +synonym: "Ca head of pancreas" EXACT [DOID:1793] +synonym: "Ca tail of pancreas" EXACT [DOID:1793] +synonym: "cancer of pancreas" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of body of pancreas" EXACT [DOID:1793] +synonym: "malignant neoplasm of head of pancreas" EXACT [DOID:1793] +synonym: "malignant neoplasm of pancreas" EXACT [MONDO:patterns/cancer, NCIT:C9005] +synonym: "malignant neoplasm of tail of pancreas" EXACT [DOID:1793] +synonym: "malignant neoplasm of the pancreas" EXACT [NCIT:C9005] +synonym: "malignant pancreas neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant pancreatic neoplasm" EXACT [NCIT:C9005] +synonym: "pancreas cancer" EXACT [MONDO:patterns/location] +synonym: "pancreas neoplasm" BROAD [DOID:1793] +synonym: "pancreatic cancer" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:1793 {source="MONDO:equivalentTo"} +xref: EFO:1000359 {source="MONDO:equivalentTo"} +xref: ICD9:157.0 {source="DOID:1793"} +xref: ICD9:157.1 {source="DOID:1793"} +xref: ICD9:157.2 {source="DOID:1793"} +xref: ICD9:157.8 {source="DOID:1793"} +xref: KEGG:05212 {source="DOID:1793", source="MONDO:relatedTo"} +xref: NCIT:C9005 {source="MONDO:equivalentTo"} +is_a: MONDO:0002516 {source="MONDO:Redundant", source="NCIT:C9005"} ! digestive system cancer +is_a: MONDO:0021040 {source="EFO:1000359", source="MONDO:Redundant", source="NCIT:C9005"} ! pancreatic neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001264 ! pancreas +relationship: disease_has_feature HP:0001735 {source="MONDO:Wikidata"} ! Acute pancreatitis +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +relationship: disease_has_feature MONDO:0006515 {source="MONDO:Wikidata"} ! acute pancreatitis +property_value: exactMatch DOID:1793 +property_value: exactMatch NCIT:C9005 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0009837 +name: choroid plexus papilloma +def: "Papilloma of the choroid plexus is a rare benign type of choroid plexus tumor, accounting for 1% of all brain tumors, often occurring in the fourth ventricle (in adults) and the lateral ventricle (in children) but sometimes arising ectopically in the brain parenchyma, and presenting with nausea, vomiting, papilledema, abnormal eye movements, as well as enlarged head circumference, seizures and gait impairment due to an increase in intracranial pressure." [Orphanet:2807] +subset: ordo_disease {source="Orphanet:2807"} +synonym: "childhood choroid plexus papilloma" NARROW [DOID:2626] +synonym: "childhood papilloma of choroid plexus" NARROW [DOID:2626] +synonym: "choroid plexus carcinoma" RELATED [OMIM:260500] +synonym: "choroid plexus papilloma" EXACT [MONDO:patterns/location, NCIT:C3698, OMIM:260500, Orphanet:2807] +synonym: "choroid plexus papilloma NOS (morphologic abnormality)" NARROW [DOID:2626] +synonym: "choroid plexus papilloma, no ICD-O subtype" EXACT [DOID:2626] +synonym: "CPP" RELATED ABBREVIATION [MONDO:Lexical, OMIM:260500, Orphanet:2807] +synonym: "papilloma of choroid plexus" RELATED [MONDO:Lexical, NCIT:C3698, OMIM:260500] +synonym: "papilloma of the choroid plexus" EXACT [DOID:2626, NCIT:C3698] +synonym: "papilloma, choroid plexus, benign" RELATED [NCIT:C3698] +synonym: "pediatric papilloma of choroid plexus" NARROW [DOID:2626, NCIT:C5800] +xref: DOID:2626 {source="MONDO:equivalentTo"} +xref: EFO:1000177 {source="MONDO:equivalentTo"} +xref: GARD:0004214 {source="MONDO:equivalentTo"} +xref: ICD10CM:D33.0 {source="Orphanet:2807/ntbt", source="Orphanet:2807"} +xref: ICDO:9390/0 {source="NCIT:C3698"} +xref: MedDRA:10008777 {source="Orphanet:2807/e", source="Orphanet:2807"} +xref: MESH:D020288 {source="Orphanet:2807/e", source="MONDO:equivalentTo", source="DOID:2626", source="Orphanet:2807"} +xref: NCIT:C3698 {source="MONDO:equivalentTo", source="DOID:2626"} +xref: OMIM:260500 {source="Orphanet:2807/e", source="MONDO:equivalentTo", source="DOID:2626", source="Orphanet:2807"} +xref: ONCOTREE:CPP {source="MONDO:equivalentTo"} +xref: Orphanet:251899 {source="OMIM:260500", source="MONDO:directSiblingOf"} +xref: Orphanet:2807 {source="OMIM:260500", source="MONDO:equivalentTo"} +xref: SCTID:425868004 {source="MONDO:equivalentTo"} +xref: UMLS:C0205770 {source="OMIM:260500", source="Orphanet:2807/e", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="DOID:2626", source="NCIT:C3698", source="Orphanet:2807"} +is_a: MONDO:0002363 {source="DOID:2626", source="MONDO:Redundant", source="NCIT:C3698"} ! papilloma +is_a: MONDO:0015953 ! genetic central nervous system and retinal vascular disease +is_a: MONDO:0044764 {source="MONDO:Redundant", source="NCIT:C3698"} ! benign choroid plexus neoplasm +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0001886 ! choroid plexus +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 {source="MONDO:mim2gene_medgen"} ! TP53 +relationship: has_modifier MONDO:0024491 {source="NCIT:C3698"} ! tumor grade 1, general grading system +property_value: closeMatch http://identifiers.org/meddra/10008777 +property_value: exactMatch DOID:2626 +property_value: exactMatch http://identifiers.org/mesh/D020288 +property_value: exactMatch http://identifiers.org/snomedct/425868004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0205770 +property_value: exactMatch https://omim.org/entry/260500 +property_value: exactMatch NCIT:C3698 +property_value: exactMatch Orphanet:2807 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: narrowMatch https://icd.codes/icd10cm/D33.0 + +[Term] +id: MONDO:0010108 +name: testicular germ cell tumor +def: "A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor." [NCIT:C8591] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:363504"} +synonym: "embryonal cell carcinoma" RELATED [OMIM:273300] +synonym: "endodermal sinus tumor" RELATED [OMIM:273300] +synonym: "germ cell neoplasm of testis" EXACT [NCIT:C8591] +synonym: "germ cell neoplasm of the testis" EXACT [NCIT:C8591] +synonym: "germ cell tumor of testis" EXACT [DOID:5557, MONDO:0018196, NCIT:C8591] +synonym: "germ cell tumor of the testis" EXACT [NCIT:C8591] +synonym: "germ cell tumors, somatic" EXACT [OMIM:273300, OMIM:genemap2] +synonym: "Male germ cell tumor" RELATED [OMIM:273300] +synonym: "male germ cell tumor, somatic" EXACT [OMIM:273300, OMIM:genemap2] +synonym: "nonseminomatous germ cell tumors" RELATED [OMIM:273300] +synonym: "seminoma" RELATED [OMIM:273300] +synonym: "spermatocytic seminoma" RELATED [OMIM:273300] +synonym: "spermatocytic seminoma, somatic" EXACT [OMIM:273300, OMIM:genemap2] +synonym: "teratoma, testicular" RELATED [OMIM:273300] +synonym: "testicular germ cell cancer" RELATED [DOID:5557] +synonym: "testicular germ cell neoplasm" EXACT [DOID:5557, NCIT:C8591] +synonym: "testicular germ cell neoplasms" EXACT [NCIT:C8591] +synonym: "testicular germ cell tumor" EXACT [MONDO:Lexical, NCIT:C8591, OMIM:273300, Orphanet:363504] +synonym: "testicular tumor, somatic" EXACT [OMIM:273300, OMIM:genemap2] +synonym: "testis germ cell tumor" EXACT [MONDO:patterns/location] +synonym: "TGCT" EXACT ABBREVIATION [MONDO:Lexical, NCIT:C8591, OMIM:273300] +xref: DOID:5557 {source="MONDO:equivalentTo"} +xref: EFO:1000566 {source="MONDO:equivalentTo"} +xref: GARD:0013047 {source="MONDO:equivalentTo"} +xref: ICD10CM:C62.1 {source="Orphanet:363504", source="Orphanet:363504/ntbt"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:C563236 {source="DOID:5557", source="MONDO:equivalentTo"} +xref: NCIT:C8591 {source="DOID:5557", source="MONDO:equivalentTo"} +xref: OMIM:273300 {source="Orphanet:363504/e", source="DOID:5557", source="MONDO:equivalentTo", source="EFO:1000566", source="Orphanet:363504"} +xref: Orphanet:363504 {source="MONDO:equivalentTo", source="OMIM:273300"} +xref: Orphanet:876 {source="MONDO:directSiblingOf", source="OMIM:273300"} +xref: SCTID:713577007 {source="DOID:5557", source="MONDO:equivalentTo"} +xref: UMLS:C0014145 {source="MONDO:directSiblingOf", source="OMIM:273300"} +xref: UMLS:C1336708 {source="DOID:5557", source="MONDO:equivalentTo", source="Orphanet:363504", source="NCIT:C8591", source="OMIM:273300"} +is_a: MONDO:0018191 {source="Orphanet:363504"} ! tumor of testis and paratestis +is_a: MONDO:0018202 {source="Orphanet:363504"} ! gonadal germ cell tumor +is_a: MONDO:0021348 {source="EFO:1000566", source="MONDO:Redundant", source="NCIT:C8591"} ! neoplasm of testis +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch DOID:5557 +property_value: exactMatch http://identifiers.org/mesh/C563236 +property_value: exactMatch http://identifiers.org/snomedct/713577007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336708 +property_value: exactMatch https://omim.org/entry/273300 +property_value: exactMatch NCIT:C8591 +property_value: exactMatch Orphanet:363504 +property_value: narrowMatch https://icd.codes/icd10cm/C62.1 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0010150 +name: head and neck squamous cell carcinoma +def: "A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands." [NCIT:C34447] +subset: ordo_disease {source="Orphanet:67037"} +synonym: "carcinoma of the head and neck" NARROW [DOID:5520, NCIT:C35850] +synonym: "craniocervical region squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "head and neck squamous cell carcinoma" EXACT [NCIT:C34447, Orphanet:67037] +synonym: "HNSCC" EXACT ABBREVIATION [MONDO:Lexical, OMIM:275355, Orphanet:67037] +synonym: "SCCHN" EXACT ABBREVIATION [NCIT:C34447] +synonym: "squamous cell carcinoma of head and neck" EXACT [NCIT:C34447] +synonym: "squamous cell carcinoma of the head and neck" EXACT [DOID:5520, NCIT:C34447] +synonym: "squamous cell carcinoma, head and neck" RELATED [MONDO:Lexical, OMIM:275355] +synonym: "squamous cell carcinoma, head and neck, somatic" EXACT [OMIM:275355, OMIM:genemap2] +synonym: "squamous cell carcinomas of head and neck" EXACT [DOID:5520] +xref: DOID:5520 {source="MONDO:equivalentTo", source="EFO:0000181"} +xref: EFO:0000181 {source="MONDO:equivalentTo"} +xref: MedDRA:10060121 {source="Orphanet:67037/e", source="Orphanet:67037"} +xref: MESH:C535575 {source="DOID:5520", source="Orphanet:67037/e", source="MONDO:equivalentTo", source="Orphanet:67037"} +xref: NCIT:C34447 {source="DOID:5520", source="MONDO:equivalentTo", source="EFO:0000181"} +xref: OMIM:275355 {source="DOID:5520", source="Orphanet:67037/e", source="MONDO:equivalentTo", source="EFO:0000181", source="Orphanet:67037"} +xref: ONCOTREE:HNSC {source="MONDO:equivalentTo"} +xref: Orphanet:67037 {source="MONDO:equivalentTo", source="OMIM:275355"} +xref: SCTID:716659002 {source="MONDO:equivalentTo"} +xref: UMLS:C1168401 {source="DOID:5520", source="Orphanet:67037/e", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:275355", source="NCIT:C34447", source="Orphanet:67037"} +is_a: MONDO:0002038 {source="DOID:5520", source="MONDO:Redundant", source="NCIT:C34447"} ! head and neck carcinoma +is_a: MONDO:0005096 {source="DOID:5520", source="EFO:0000181", source="MESH:C535575", source="MONDO:Redundant", source="NCIT:C34447"} ! squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0007811 ! craniocervical region +relationship: has_modifier MONDO:0021136 {source="MONDO:0017371"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10060121 +property_value: exactMatch DOID:5520 +property_value: exactMatch http://identifiers.org/mesh/C535575 +property_value: exactMatch http://identifiers.org/snomedct/716659002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1168401 +property_value: exactMatch https://omim.org/entry/275355 +property_value: exactMatch NCIT:C34447 +property_value: exactMatch Orphanet:67037 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0010255 +name: diabetes mellitus, insulin-dependent, X-linked, susceptibility to +subset: predisposition +synonym: "diabetes mellitus, insulin-dependent, X-linked" EXACT [OMIM:300136, OMIM:genemap2] +synonym: "diabetes mellitus, insulin-dependent, X-linked, susceptibility to" EXACT [OMIM:300136] +synonym: "Iddmx" RELATED [OMIM:300136] +synonym: "insulin-dependent diabetes mellitus, X-linked, susceptibility to" RELATED [OMIM:300136] +xref: OMIM:300136 {source="MONDO:equivalentTo"} +xref: UMLS:C1848042 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:300136"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005147 ! type 1 diabetes mellitus +relationship: predisposes_towards MONDO:0005147 ! type 1 diabetes mellitus +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1848042 +property_value: exactMatch https://omim.org/entry/300136 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0010811 +name: benign prostatic hyperplasia +def: "A non-cancerous nodular enlargement of the prostate gland. It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements. It is the most common urologic disorder in men, causing blockage of urine flow." [NCIT:C2897] +synonym: "benign hyperplasia of prostate" EXACT [NCIT:C2897] +synonym: "benign hyperplasia of the prostate" EXACT [NCIT:C2897] +synonym: "benign prostate hyperplasia" EXACT [NCIT:C2897] +synonym: "benign prostatic hyperplasia" EXACT [MONDO:ambiguous] +synonym: "benign prostatic hyperplasia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "benign prostatic hyperplasia - BPH" EXACT [NCIT:C2897] +synonym: "benign prostatic Hypertrophy" EXACT [NCIT:C2897] +synonym: "benign prostatic hypertrophy" EXACT [NCIT:C2897] +synonym: "BPH" RELATED ABBREVIATION [MONDO:Lexical, OMIM:600082] +synonym: "prostate hypertrophy" BROAD [] +synonym: "prostatic hyperplasia, benign" RELATED [MONDO:Lexical, OMIM:600082] +synonym: "prostatic hypertrophy" BROAD [] +xref: DOID:11132 {source="EFO:0000284", source="MONDO:equivalentTo"} +xref: DOID:2883 {source="EFO:0000284", source="MONDO:directSiblingOf"} +xref: EFO:0000284 {source="MONDO:equivalentTo"} +xref: HP:0008711 {source="MONDO:otherHierarchy"} +xref: ICD9:600 {source="EFO:0000284"} +xref: ICD9:600.0 {source="EFO:0000284"} +xref: ICD9:600.20 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D011470 {source="EFO:0000284", source="MONDO:equivalentTo"} +xref: NCIT:C2897 {source="EFO:0000284", source="MONDO:equivalentTo"} +xref: OMIM:600082 {source="EFO:0000284", source="MONDO:equivalentTo"} +xref: SCTID:266569009 {source="EFO:0000284", source="MONDO:equivalentTo"} +xref: UMLS:C1704272 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:600082"} +is_a: MONDO:0003105 {source="DOID:11132", source="MESH:D011470", source="MONDO:Redundant"} ! prostate disorder +is_a: MONDO:0005043 {source="EFO:0000284", source="MONDO:Redundant", source="NCIT:C2897"} ! hyperplasia +intersection_of: MONDO:0005043 ! hyperplasia +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:11132 +property_value: exactMatch http://identifiers.org/mesh/D011470 +property_value: exactMatch http://identifiers.org/snomedct/266569009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1704272 +property_value: exactMatch https://omim.org/entry/600082 +property_value: exactMatch NCIT:C2897 +property_value: IAO:0000589 "benign prostatic hyperplasia (disease)" xsd:string + +[Term] +id: MONDO:0010940 +name: inherited susceptibility to asthma +subset: predisposition +synonym: "asthma, bronchial" RELATED [OMIM:600807] +synonym: "asthma, diminished response to Antileukotriene treatment 1N" RELATED [OMIM:600807] +synonym: "asthma, diminished response to antileukotriene treatment in" EXACT [OMIM:600807, OMIM:genemap2] +synonym: "asthma, nocturnal, susceptibility to" EXACT [OMIM:600807, OMIM:genemap2] +synonym: "asthma, protection against" RELATED [OMIM:600807] +synonym: "asthma, susceptibility to" RELATED [OMIM:600807] +synonym: "asthma-related traits, susceptibility to" RELATED [OMIM:600807] +xref: OMIM:600807 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0004979 ! asthma +relationship: predisposes_towards MONDO:0004979 ! asthma +property_value: exactMatch https://omim.org/entry/600807 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0011057 +name: cerebrovascular disorder +def: "A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction." [NCIT:C2938] +synonym: "cerebral infarction" NARROW [OMIM:601367] +synonym: "cerebrovascular accident" NARROW [DOID:6713] +synonym: "cerebrovascular disease" EXACT [ISBN-13:978-1-259-64403-0, NCIT:C2938] +synonym: "cerebrovascular disorder" EXACT [DOID:6713, NCIT:C2938] +synonym: "CVA" NARROW ABBREVIATION [DOID:6713] +synonym: "CVA (cerebral vascular accident)" NARROW [DOID:6713] +synonym: "stroke" NARROW [DOID:6713] +xref: DOID:6713 {source="EFO:0003763", source="MONDO:equivalentTo"} +xref: EFO:0003763 {source="MONDO:equivalentTo"} +xref: ICD10CM:I60-I69 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="DOID:6713", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:430-438.99 {source="EFO:0003763", source="DOID:6713"} +xref: ICD9:434.91 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:437.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:437.9 {source="MONDO:equivalentTo", source="DOID:6713", source="MONDO:i2s"} +xref: MESH:D002561 {source="EFO:0003763", source="MONDO:equivalentTo", source="DOID:6713"} +xref: NCIT:C2938 {source="EFO:0003763", source="MONDO:equivalentTo", source="DOID:6713"} +xref: SCTID:62914000 {source="EFO:0003763", source="MONDO:equivalentTo", source="DOID:6713"} +xref: UMLS:C0007820 {source="NCIT:C2938", source="MONDO:equivalentTo", source="DOID:6713"} +is_a: MONDO:0005560 {source="DOID:6713", source="MESH:D002561", source="MONDO:Redundant"} ! brain disorder +is_a: MONDO:0020676 ! disorder of central nervous system or retinal vasculature +is_a: MONDO:0043218 ! neurovascular disorder +relationship: disease_has_location UBERON:0008998 ! vasculature of brain +property_value: exactMatch DOID:6713 +property_value: exactMatch http://identifiers.org/mesh/D002561 +property_value: exactMatch http://identifiers.org/snomedct/62914000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007820 +property_value: exactMatch https://icd.codes/icd10cm/I60-I69 +property_value: exactMatch NCIT:C2938 +property_value: excluded_subClassOf MONDO:0000473 {source="DOID:6713"} + +[Term] +id: MONDO:0011260 +name: pancreatic lymphoma, familial +def: "An instance of pancreas lymphoma that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: predisposition +synonym: "hereditary pancreas lymphoma" EXACT [MONDO:patterns/hereditary] +synonym: "pancreatic lymphoma, familial" EXACT [OMIM:602596] +xref: MESH:C566516 {source="MONDO:equivalentTo"} +xref: OMIM:602596 {source="MONDO:equivalentTo"} +xref: UMLS:C1865139 {source="OMIM:602596", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline"} +is_a: MONDO:0002114 ! pancreas lymphoma +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0002114 ! pancreas lymphoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/C566516 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1865139 +property_value: exactMatch https://omim.org/entry/602596 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0011366 +name: ovarian germ cell tumor +def: "A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma." [NCIT:C3873] +comment: Editor note: we make this equivalent to DOID:2156, despite the fact the DOID has 'cancer' in the label it's placement in the ontology is consistent with the broader 'tumor' +synonym: "germ cell neoplasm of ovary" EXACT [DOID:2156, NCIT:C3873] +synonym: "germ cell neoplasm of the ovary" EXACT [NCIT:C3873] +synonym: "germ cell tumor of ovary" EXACT [NCIT:C3873] +synonym: "germ cell tumor of the ovary" EXACT [NCIT:C3873] +synonym: "ovarian germ cell cancer" RELATED [OMIM:603737] +synonym: "ovarian germ cell neoplasm" EXACT [NCIT:C3873] +synonym: "ovarian germ cell tumor" EXACT [DOID:2156, NCIT:C3873] +synonym: "ovary germ cell tumor" EXACT [MONDO:patterns/location] +xref: DOID:2156 {source="MONDO:equivalentTo"} +xref: EFO:1000419 {source="MONDO:equivalentTo"} +xref: GARD:0009330 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3873 {source="EFO:1000419", source="DOID:2156", source="MONDO:equivalentTo"} +xref: OMIM:603737 {source="DOID:2156", source="MONDO:equivalentTo"} +xref: ONCOTREE:OGCT {source="MONDO:equivalentTo"} +xref: SCTID:237059008 {source="DOID:2156", source="MONDO:equivalentTo"} +xref: UMLS:C0238324 {source="DOID:2156", source="MONDO:equivalentTo", source="NCIT:C3873"} +is_a: MONDO:0005040 {source="EFO:1000419", source="MONDO:Redundant", source="NCIT:C3873"} ! germ cell tumor +is_a: MONDO:0021068 {source="MONDO:Redundant", source="NCIT:C3873"} ! ovarian neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:2156 +property_value: exactMatch http://identifiers.org/snomedct/237059008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238324 +property_value: exactMatch https://omim.org/entry/603737 +property_value: exactMatch NCIT:C3873 + +[Term] +id: MONDO:0011775 +name: nasopharyngeal carcinoma, susceptibility to, 1 +def: "Any nasopharyngeal carcinoma in which the cause of the disease is a mutation in the TP53 gene." [MONDO:patterns/disease_series_by_gene] +subset: predisposition +synonym: "nasopharyngeal cancer" RELATED [OMIM:607107] +synonym: "nasopharyngeal carcinoma" RELATED [OMIM:607107] +synonym: "nasopharyngeal carcinoma 1" EXACT [OMIM:607107, OMIM:genemap2] +synonym: "nasopharyngeal carcinoma caused by mutation in TP53" EXACT [MONDO:design_pattern] +synonym: "nasopharyngeal carcinoma, somatic" EXACT [OMIM:607107, OMIM:genemap2] +synonym: "nasopharyngeal carcinoma, susceptibility to, 1" EXACT [OMIM:607107] +synonym: "NPC" RELATED ABBREVIATION [OMIM:607107] +synonym: "Npca" RELATED [OMIM:607107] +synonym: "TP53 nasopharyngeal carcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/disease_series_by_gene] +xref: OMIM:607107 {source="MONDO:equivalentTo"} +xref: UMLS:C1846758 {source="OMIM:607107", source="MONDO:equivalentTo"} +is_a: MONDO:0015459 {source="DC-OMIM:607107", source="MONDO:Redundant", source="MONDO:cjm"} ! nasopharyngeal carcinoma +is_a: MONDO:0017128 ! inherited digestive tract tumor +is_a: MONDO:0018751 ! genetic otorhinolaryngologic disease +intersection_of: MONDO:0015459 ! nasopharyngeal carcinoma +intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 ! TP53 +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 {source="MONDO:mim2gene_medgen"} ! TP53 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1846758 +property_value: exactMatch https://omim.org/entry/607107 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0011786 +name: allergic rhinitis +def: "Inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea, and itching. It may lead to fatigue, drowsiness, and malaise thus causing impairment of the quality of life." [NCIT:C79532] +synonym: "allergic form of rhinitis" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic rhinitis" EXACT [NCIT:C79532, OMIM:607154] +synonym: "allergic rhinitis, susceptibility to" EXACT [OMIM:607154, OMIM:genemap2] +synonym: "Alrh" RELATED [OMIM:607154] +synonym: "atopic rhinitis" EXACT [DOID:4481] +synonym: "non-seasonal allergic rhinitis" NARROW [DOID:4481] +synonym: "Perenial allergic rhinitis" NARROW [DOID:4481] +synonym: "perennial allergic rhinitis" NARROW [DOID:4481] +synonym: "pollenosis" EXACT [DOID:4481] +synonym: "seasonal allergic rhinitis" NARROW [DOID:4481] +xref: DOID:4481 {source="EFO:0005854", source="MONDO:equivalentTo"} +xref: EFO:0005854 {source="MONDO:equivalentTo"} +xref: HP:0003193 {source="EFO:0005854", source="MONDO:otherHierarchy"} +xref: ICD9:477 {source="EFO:0005854"} +xref: ICD9:477.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:477.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C79532 {source="EFO:0005854", source="MONDO:equivalentTo"} +xref: OMIM:607154 {source="EFO:0005854", source="MONDO:equivalentTo", source="DOID:4481"} +xref: SCTID:61582004 {source="EFO:0005854", source="MONDO:equivalentTo"} +xref: UMLS:C2607914 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="NCIT:C79532", source="OMIM:607154"} +is_a: MONDO:0000771 ! allergic respiratory disease +is_a: MONDO:0003014 {source="DOID:4481", source="MONDO:Redundant", source="NCIT:C79532"} ! rhinitis +is_a: MONDO:0018751 ! genetic otorhinolaryngologic disease +intersection_of: MONDO:0003014 ! rhinitis +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/5973 {source="MONDO:mim2gene_medgen"} ! IL13 +property_value: exactMatch DOID:4481 +property_value: exactMatch http://identifiers.org/snomedct/61582004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2607914 +property_value: exactMatch https://omim.org/entry/607154 +property_value: exactMatch NCIT:C79532 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/allergic_form_of_disease.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0011789 +name: familial meningioma +def: "A meningioma that is transmitted from the parents to an offspring." [NCIT:P378] +synonym: "familial meningioma" EXACT [NCIT:C5301] +synonym: "hereditary meningioma" EXACT [NCIT:C5301] +synonym: "hereditary meningioma (disease)" EXACT [MONDO:patterns/hereditary] +synonym: "meningioma" BROAD [OMIM:607174, OMIM:genemap2] +synonym: "meningioma, familial, susceptibility to" RELATED [OMIM:607174] +synonym: "meningioma, NF2-related, somatic" EXACT [OMIM:607174, OMIM:genemap2] +synonym: "meningioma, SIS-related" EXACT [OMIM:607174, OMIM:genemap2] +synonym: "susceptibility to familial meningioma" RELATED [OMIM:607174] +xref: DOID:4586 {source="MONDO:equivalentTo"} +xref: MESH:C537443 {source="DOID:4586", source="MONDO:equivalentTo"} +xref: NCIT:C5301 {source="DOID:4586", source="MONDO:equivalentTo"} +xref: OMIM:607174 {source="DOID:4586", source="MONDO:equivalentTo"} +xref: UMLS:C1333989 {source="DOID:4586", source="MONDO:equivalentTo", source="NCIT:C5301", source="MONDO:ncbi_mim2gene_medline"} +is_a: MONDO:0016642 ! meningioma +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0020573 {source="OMIM:607174"} ! inherited disease susceptibility +intersection_of: MONDO:0016642 ! meningioma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:4586 +property_value: exactMatch http://identifiers.org/mesh/C537443 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333989 +property_value: exactMatch https://omim.org/entry/607174 +property_value: exactMatch NCIT:C5301 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0011962 +name: endometrial cancer +def: "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity)." [NCIT:C27815] +synonym: "cancer of endometrium" EXACT [MONDO:patterns/cancer] +synonym: "endometrial Ca" EXACT [DOID:1380] +synonym: "endometrial cancer" EXACT [OMIM:608089] +synonym: "endometrial cancer, familial, autosomal dominant, somatic mutation" EXACT [OMIM:608089, OMIM:genemap2] +synonym: "endometrial cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:608089, OMIM:genemap2] +synonym: "endometrial carcinoma, somatic" EXACT [OMIM:608089, OMIM:genemap2] +synonym: "endometrial neoplasm" BROAD [DOID:1380] +synonym: "endometrium cancer" EXACT [MONDO:patterns/location] +synonym: "malignant endometrial neoplasm" EXACT [DOID:1380, NCIT:C27815] +synonym: "malignant endometrium neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of endometrium" EXACT [DOID:1380, MONDO:patterns/cancer] +synonym: "neoplasm of endometrium" BROAD [DOID:1380] +synonym: "primary malignant neoplasm of endometrium" EXACT [DOID:1380] +synonym: "tumor of endometrium" BROAD [DOID:1380, NCIT:C3012] +xref: DOID:1380 {source="MONDO:equivalentTo"} +xref: EFO:0004230 {source="MONDO:equivalentTo", source="DOID:1380"} +xref: GARD:0011981 {source="MONDO:equivalentTo"} +xref: KEGG:05213 {source="MONDO:relatedTo", source="DOID:1380"} +xref: NCIT:C27815 {source="MONDO:equivalentTo", source="DOID:1380"} +xref: OMIM:608089 {source="MONDO:equivalentTo", source="DOID:1380"} +is_a: MONDO:0002715 {source="DOID:1380", source="MONDO:Redundant", source="NCIT:C27815/inferred"} ! uterine cancer +is_a: MONDO:0021251 {source="MONDO:Redundant", source="NCIT:C27815"} ! endometrium neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch DOID:1380 +property_value: exactMatch https://omim.org/entry/608089 +property_value: exactMatch NCIT:C27815 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0012004 +name: parathyroid gland carcinoma +def: "A very rare, slow-growing, clinically serious endocrine tumor that generally develops in mid-adulthood. PRTC presents as a palpable painless mass in the neck and causes severe hypercalcemia and related symptoms, non-specific gastrointestinal manifestations, as well as renal and bone complications related to primary hyperparathyroidism (nephrolithiasis, impaired renal function, osteoporosis, bone pain, and pathologic fractures, etc.). Some PRTCs are however non-functioning tumors." [https://orcid.org/0000-0001-5208-3432, Orphanet:143] +subset: ordo_disease {source="Orphanet:143"} +synonym: "adenocarcinoma of parathyroid" EXACT [NCIT:C4906] +synonym: "adenocarcinoma of parathyroid gland" EXACT [NCIT:C4906] +synonym: "adenocarcinoma of the parathyroid" EXACT [NCIT:C4906] +synonym: "adenocarcinoma of the parathyroid gland" EXACT [NCIT:C4906] +synonym: "cancer of parathyroid gland" BROAD [NCIT:C4906] +synonym: "cancer of the parathyroid gland" BROAD [NCIT:C4906] +synonym: "carcinoma of parathyroid" EXACT [NCIT:C4906] +synonym: "carcinoma of parathyroid gland" EXACT [DOID:1540, MONDO:patterns/carcinoma, NCIT:C4906] +synonym: "carcinoma of the parathyroid" EXACT [NCIT:C4906] +synonym: "carcinoma of the parathyroid gland" EXACT [NCIT:C4906] +synonym: "malignant neoplasm of parathyroid gland" BROAD [DOID:1540, ICD9CM:194.1] +synonym: "malignant neoplasm of the parathyroid" BROAD [DOID:1540, NCIT:C9322] +synonym: "parathyroid adenocarcinoma" EXACT [NCIT:C4906] +synonym: "parathyroid cancer" BROAD [NCIT:C4906] +synonym: "parathyroid carcinoma" EXACT [NCIT:C4906, OMIM:608266] +synonym: "parathyroid gland adenocarcinoma" EXACT [DOID:1540, NCIT:C4906] +synonym: "parathyroid gland cancer" BROAD [DOID:1540, NCIT:C4906] +synonym: "parathyroid gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C4906] +synonym: "parathyroid gland neoplasm" BROAD [DOID:1540, NCIT:C3313] +synonym: "parathyroid neoplasm" BROAD [DOID:1540] +synonym: "PRTC" RELATED ABBREVIATION [OMIM:608266] +xref: DOID:1540 {source="MONDO:equivalentTo"} +xref: EFO:1000456 {source="MONDO:equivalentTo"} +xref: GARD:0007329 {source="MONDO:equivalentTo"} +xref: ICD10CM:C75.0 {source="DOID:1540", source="Orphanet:143/ntbt", source="Orphanet:143"} +xref: ICD9:194.1 {source="DOID:1540"} +xref: NCIT:C4906 {source="DOID:1540", source="MONDO:equivalentTo", source="EFO:1000456"} +xref: OMIM:608266 {source="DOID:1540", source="Orphanet:143/e", source="MONDO:equivalentTo", source="EFO:1000456", source="Orphanet:143"} +xref: ONCOTREE:PTHC {source="MONDO:equivalentTo"} +xref: Orphanet:143 {source="MONDO:equivalentTo", source="OMIM:608266"} +xref: SCTID:255037004 {source="DOID:1540", source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0004970 {source="NCIT:C4906"} ! adenocarcinoma +is_a: MONDO:0021311 {source="MONDO:Redundant", source="NCIT:C4906", source="ONCOTREE:PTHC"} ! malignant tumor of parathyroid gland +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/16783 {source="MONDO:mim2gene_medgen"} ! CDC73 +relationship: has_modifier MONDO:0021136 {source="MONDO:0015076"} ! rare +property_value: exactMatch DOID:1540 +property_value: exactMatch http://identifiers.org/snomedct/255037004 +property_value: exactMatch https://omim.org/entry/608266 +property_value: exactMatch NCIT:C4906 +property_value: exactMatch Orphanet:143 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C75.0 + +[Term] +id: MONDO:0012503 +name: thiopurine S-methyltransferase deficiency +def: "An acquired metabolic disease that is has its basis in the disruption of thiopurine S-methyltransferase activity." [MONDO:patterns/inborn_metabolic] +synonym: "6-mercaptopurine sensitivity" RELATED [GARD:0005173] +synonym: "inborn error of thiopurine S-methyltransferase activity" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn thiopurine S-methyltransferase activity disorder" EXACT [] +synonym: "poor metabolism of thiopurines-1" EXACT [DOID:0080172] +synonym: "rare inborn error of thiopurine S-methyltransferase activity" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "thiopurine methyltransferase deficiency" RELATED [GARD:0005173] +synonym: "thiopurine S methyltranferase deficiency" RELATED [GARD:0005173] +synonym: "thiopurine S-methyltransferase deficiency" EXACT [OMIM:610460] +synonym: "Thiopurines, poor metabolism of" RELATED [OMIM:610460] +synonym: "Thiopurines, poor metabolism of, 1" RELATED [OMIM:610460] +synonym: "thiopurines, poor metabolism of, 1" RELATED [OMIM:610460] +synonym: "THPM1" RELATED ABBREVIATION [OMIM:610460] +synonym: "TPMT deficiency" EXACT [DOID:0080172, OMIM:610460] +xref: DOID:0080172 {source="MONDO:equivalentTo"} +xref: GARD:0005173 {source="MONDO:equivalentTo"} +xref: MESH:C536512 {source="MONDO:equivalentTo"} +xref: NCIT:C4389 {source="MONDO:equivalentTo"} +xref: OMIM:610460 {source="MONDO:equivalentTo", source="DOID:0080172"} +xref: Orphanet:3315 {source="OMIM:610460", source="MONDO:equivalentTo"} +xref: SCTID:238012003 {source="MONDO:equivalentTo"} +is_a: MONDO:0000210 {source="DC-OMIM:610460", source="OMIM:610460"} ! thiopurine metabolic disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0008119 ! thiopurine S-methyltransferase activity +relationship: disease_has_basis_in_disruption_of GO:0008119 ! thiopurine S-methyltransferase activity +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/12014 {source="MONDO:mim2gene_medgen"} ! TPMT +property_value: exactMatch DOID:0080172 +property_value: exactMatch http://identifiers.org/mesh/C536512 +property_value: exactMatch http://identifiers.org/snomedct/238012003 +property_value: exactMatch https://omim.org/entry/610460 +property_value: exactMatch NCIT:C4389 +property_value: exactMatch Orphanet:3315 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0012521 +name: herpes simplex encephalitis +def: "Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness." [Orphanet:1930] +subset: gard_rare {source="GARD:0006649"} +subset: ordo_disease {source="Orphanet:1930"} +synonym: "Herpes simplex meningo-encephalitis" EXACT [Orphanet:1930] +synonym: "Herpes simplex neuroinvasion" EXACT [Orphanet:1930] +synonym: "Herpes simplex virus encephalitis" RELATED [Orphanet:1930] +synonym: "herpetic encephalitis" EXACT [Orphanet:1930] +synonym: "HSE" EXACT ABBREVIATION [Orphanet:1930] +synonym: "HSV encephalitis" EXACT [Orphanet:1930] +synonym: "HSVE" EXACT ABBREVIATION [Orphanet:1930] +synonym: "Simplexvirus caused infectious encephalitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Simplexvirus infectious encephalitis" EXACT [] +xref: GARD:0006649 {source="MONDO:equivalentTo"} +xref: ICD10EXP:B00.4+ {source="Orphanet:1930", source="Orphanet:1930/specific", source="Orphanet:1930/e"} +xref: ICD10EXP:G05.1* {source="Orphanet:1930", source="Orphanet:1930/specific", source="Orphanet:1930/e"} +xref: MESH:D020803 {source="MONDO:equivalentTo"} +xref: NCIT:C84762 {source="MONDO:equivalentTo"} +xref: OMIM:613002 {source="Orphanet:1930", source="Orphanet:1930/btnt"} +xref: OMIM:614849 {source="Orphanet:1930", source="Orphanet:1930/btnt"} +xref: OMIM:614850 {source="Orphanet:1930", source="Orphanet:1930/btnt"} +xref: OMIM:616532 {source="Orphanet:1930", source="Orphanet:1930/btnt"} +xref: Orphanet:1930 {source="OMIM:610551", source="MONDO:equivalentTo"} +is_a: MONDO:0004609 ! herpes simplex infectious disease +is_a: MONDO:0006009 {source="MONDO:Redundant", source="NCIT:C84762", source="Orphanet:1930"} ! viral encephalitis +is_a: MONDO:0015979 {source="Orphanet:1930"} ! hereditary predisposition to infections +is_a: MONDO:0019117 ! genetic nervous system disorder +intersection_of: MONDO:0020067 ! infectious encephalitis +intersection_of: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +property_value: exactMatch http://identifiers.org/mesh/D020803 +property_value: exactMatch NCIT:C84762 +property_value: exactMatch Orphanet:1930 +property_value: excluded_subClassOf MONDO:0015659 {source="Orphanet:1930"} +property_value: excluded_subClassOf MONDO:0020141 {source="Orphanet:1930"} +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6649/herpes-simplex-encephalitis xsd:anyURI {source="GARD:0006649"} + +[Term] +id: MONDO:0012819 +name: diabetic ketoacidosis +def: "The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids." [NCIT:P378] +synonym: "diabetes mellitus, ketosis-prone" EXACT [DOID:1837, MONDO:Lexical, OMIM:612227] +synonym: "diabetes mellitus, ketosis-prone, susceptibility to" EXACT [OMIM:612227, OMIM:genemap2] +synonym: "ketosis-prone diabetes mellitus" EXACT [DOID:1837] +synonym: "KPD" RELATED ABBREVIATION [MONDO:Lexical, OMIM:612227] +xref: DOID:1837 {source="MONDO:equivalentTo", source="EFO:1000897"} +xref: EFO:1000897 {source="MONDO:equivalentTo"} +xref: ICD9:250.1 {source="DOID:1837"} +xref: ICD9:250.10 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10012671 {source="EFO:1000897"} +xref: MESH:D016883 {source="MONDO:equivalentTo", source="EFO:1000897", source="DOID:1837"} +xref: NCIT:C50530 {source="MONDO:otherHierarchy", source="EFO:1000897", source="DOID:1837"} +xref: OMIM:612227 {source="MONDO:equivalentTo", source="DOID:1837"} +xref: SCTID:420422005 {source="MONDO:equivalentTo", source="EFO:1000897", source="DOID:1837"} +xref: UMLS:C0011880 {source="MONDO:equivalentTo", source="DOID:1837"} +is_a: MONDO:0005015 {source="https://orcid.org/0000-0003-0978-0309"} ! diabetes mellitus +is_a: MONDO:0019052 ! inborn errors of metabolism +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/8618 {source="MONDO:mim2gene_medgen"} ! PAX4 +property_value: closeMatch http://identifiers.org/meddra/10012671 +property_value: exactMatch DOID:1837 +property_value: exactMatch http://identifiers.org/mesh/D016883 +property_value: exactMatch http://identifiers.org/snomedct/420422005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011880 +property_value: exactMatch https://omim.org/entry/612227 +property_value: excluded_subClassOf MONDO:0005148 {source="DOID:1837"} +property_value: relatedMatch NCIT:C50530 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4859 xsd:string + +[Term] +id: MONDO:0013099 +name: combined pituitary hormone deficiencies, genetic form +def: "Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis. Congenital hypopituitarism is rare compared with the high incidence of hypopituitarism induced by pituitary adenomas, transsphenoidal surgery or radiotherapy." [Orphanet:95494] +subset: gard_rare +subset: ordo_disease {source="Orphanet:95494"} +synonym: "combined pituitary hormone deficiencies, genetic forms" RELATED [Orphanet:95494] +synonym: "familial congenital hypopituitarism" EXACT [Orphanet:95494] +synonym: "familial hypopituitarism" RELATED [GARD:0002252] +synonym: "genetic hypopituitarism" EXACT [MONDO:patterns/genetic] +synonym: "multiple pituitary hormone deficiencies, genetic forms" EXACT [Orphanet:95494] +synonym: "pituitary hormone deficiency, combined" EXACT [OMIMPS:613038] +xref: GARD:0002252 {source="MONDO:equivalentTo"} +xref: GARD:0010602 {source="MONDO:equivalentTo"} +xref: ICD10CM:E23.0 {source="MONDO:relatedTo", source="Orphanet:95494/attributed", source="Orphanet:95494/ntbt", source="Orphanet:95494"} +xref: OMIM:182230 {source="Orphanet:95494/btnt", source="Orphanet:95494"} +xref: OMIM:262600 {source="Orphanet:95494/btnt", source="Orphanet:95494"} +xref: OMIM:613986 {source="Orphanet:95494/btnt", source="Orphanet:95494"} +xref: OMIMPS:613038 {source="MONDO:equivalentTo"} +xref: SCTID:718182008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002320 ! congenital nervous system disorder +is_a: MONDO:0005152 ! hypopituitarism +is_a: MONDO:0015770 {source="MONDO:0015891-obsoleted", source="https://github.com/monarch-initiative/mondo/pull/2571/"} ! congenital hypogonadotropic hypogonadism +is_a: MONDO:0019117 ! genetic nervous system disorder +intersection_of: MONDO:0005152 ! hypopituitarism +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/718182008 +property_value: exactMatch https://omim.org/phenotypicSeries/PS613038 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/2252/familial-hypopituitarism xsd:anyURI {source="GARD:0002252"} +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0013876 +name: basal cell carcinoma, susceptibility to, 7 +def: "Any skin basal cell carcinoma in which the cause of the disease is a mutation in the TP53 gene." [MONDO:patterns/disease_series_by_gene] +subset: predisposition +synonym: "basal cell carcinoma 7" EXACT [OMIM:614740, OMIM:genemap2] +synonym: "basal cell carcinoma, susceptibility to, 7" EXACT [MONDO:Lexical, OMIM:614740] +synonym: "basal cell carcinoma, susceptibility to, type 7" EXACT [MONDORULE:1, OMIM:614740] +synonym: "BCC7" RELATED ABBREVIATION [MONDO:Lexical, OMIM:614740] +synonym: "skin basal cell carcinoma caused by mutation in TP53" EXACT [MONDO:design_pattern] +synonym: "susceptibility to basal cell carcinoma 7" RELATED [OMIM:614740] +synonym: "TP53 skin basal cell carcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/disease_series_by_gene] +xref: OMIM:614740 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 ! TP53 +intersection_of: predisposes_towards MONDO:0005341 ! skin basal cell carcinoma +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/11998 {source="MONDO:mim2gene_medgen"} ! TP53 +relationship: predisposes_towards MONDO:0005341 ! skin basal cell carcinoma +property_value: exactMatch https://omim.org/entry/614740 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0014471 +name: mitochondrial proton-transporting ATP synthase complex deficiency +def: "A rare, genetic, mitochondrial oxidative phosphorylation disorder that may present with a wide range of symptoms (including muscular hypotonia, hypertrophic cardiomyopathy, psychomotor delay, encephalopathy, peripheral neuropathy, lactic acidosis, 3-methylglutaconic aciduria) and clinical syndromes (including NARP and MILS)." [Orphanet:254913] +comment: Consider splitting out nuclear type for OMIMPS +subset: ordo_disease {source="Orphanet:254913"} +synonym: "isolated ATP synthase deficiency" NARROW [Orphanet:254913] +synonym: "isolated mitochondrial respiratory chain complex V deficiency" NARROW [Orphanet:254913] +synonym: "mitochondrial complex V (ATP synthase) deficiency" EXACT [DOID:0111143] +xref: DOID:0111143 {source="MONDO:equivalentTo"} +xref: ICD10CM:E88.8 {source="Orphanet:254913/attributed", source="Orphanet:254913/ntbt", source="Orphanet:254913"} +xref: OMIM:604273 {source="Orphanet:254913/btnt", source="Orphanet:254913"} +xref: OMIM:614053 {source="Orphanet:254913/btnt", source="Orphanet:254913"} +xref: OMIM:615228 {source="Orphanet:254913/btnt", source="Orphanet:254913"} +xref: OMIMPS:604273 {source="MONDO:equivalentTo"} +xref: Orphanet:254913 {source="MONDO:equivalentTo", source="OMIM:616045"} +xref: UMLS:C4015062 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline"} +is_a: MONDO:0000732 {source="DC-OMIM:616045", source="OMIM:616045"} ! combined oxidative phosphorylation deficiency +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex +relationship: disease_has_basis_in_dysfunction_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex +property_value: exactMatch DOID:0111143 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4015062 +property_value: exactMatch https://omim.org/phenotypicSeries/PS604273 +property_value: exactMatch Orphanet:254913 +property_value: excluded_subClassOf MONDO:0016805 {source="Orphanet:254913"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E88.8 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0014491 +name: immunodeficiency 37 +def: "Any primary immunodeficiency disease in which the cause of the disease is a mutation in the BCL10 gene." [MONDO:patterns/disease_series_by_gene] +synonym: "BCL10 primary immunodeficiency disease" EXACT [MONDO:design_pattern, MONDO:patterns/disease_series_by_gene] +synonym: "IMD37" RELATED ABBREVIATION [MONDO:Lexical, OMIM:616098] +synonym: "immunodeficiency 37" EXACT [MONDO:Lexical, OMIM:616098] +synonym: "immunodeficiency type 37" EXACT [MONDORULE:2, OMIM:616098] +synonym: "primary immunodeficiency disease caused by mutation in BCL10" EXACT [MONDO:design_pattern] +xref: OMIM:616098 {source="MONDO:equivalentTo"} +xref: UMLS:C4015195 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline"} +is_a: MONDO:0003778 {source="DC-OMIM:616098", source="MONDO:Redundant"} ! inborn errors of immunity +intersection_of: MONDO:0003778 ! inborn errors of immunity +intersection_of: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/989 ! BCL10 +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/989 {source="MONDO:mim2gene_medgen"} ! BCL10 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4015195 +property_value: exactMatch https://omim.org/entry/616098 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0015062 +name: gastric neuroendocrine tumor, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the stomach." [NCIT:C95871] +subset: ordo_disease {source="Orphanet:100075"} +synonym: "gastric NET" EXACT [NCIT:C95871] +synonym: "gastric NET G1/2" EXACT [MONDO:cjm] +synonym: "gastric neuroendocrine tumor" EXACT [NCIT:C95871] +synonym: "gastric well differentiated endocrine tumor" EXACT [NCIT:C95871] +synonym: "gastric well differentiated endocrine tumor/carcinoma" EXACT [NCIT:C95871] +synonym: "GNET" EXACT ABBREVIATION [Orphanet:100075] +synonym: "well-differentiated neuroendocrine tumors of the stomach" RELATED [ONCOTREE:SWDNET] +xref: NCIT:C95871 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:SWDNET {source="MONDO:equivalentTo"} +xref: UMLS:C3272399 {source="MONDO:equivalentTo", source="NCIT:C95871"} +xref: UMLS:CN197355 {source="MONDO:equivalentTo"} +is_a: MONDO:0000386 {source="MONDO:Redundant", source="NCIT:C95871", source="ONCOTREE:SWDNET"} ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0003111 {source="NCIT:C95871"} ! gastric neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000945 ! stomach +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3272399 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197355 +property_value: exactMatch NCIT:C95871 + +[Term] +id: MONDO:0015063 +name: duodenal neuroendocrine tumor, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the duodenum." [NCIT:C135080] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:100076"} +synonym: "duodenal neuroendocrine tumor" EXACT [NCIT:C135080] +xref: NCIT:C135080 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:100076 {source="MONDO:equivalentTo"} +xref: UMLS:CN197356 {source="MONDO:equivalentTo"} +is_a: MONDO:0002995 {source="MONDO:Redundant", source="NCIT:C135080"} ! small intestine neuroendocrine tumor, well differentiated, low or intermediate grade +is_a: MONDO:0024500 ! duodenal neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002114 ! duodenum +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197356 +property_value: exactMatch NCIT:C135080 +property_value: exactMatch Orphanet:100076 + +[Term] +id: MONDO:0015064 +name: jejunal neuroendocrine tumor, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the jejunum." [NCIT:C135090] +comment: Editor note: TODO apply G1/G2 pattern +subset: ordo_disease {source="Orphanet:100077"} +synonym: "jejunal neuroendocrine neoplasm" EXACT [Orphanet:100077] +synonym: "jejunal neuroendocrine tumor" RELATED [Orphanet:100077] +xref: NCIT:C135090 {source="MONDO:equivalentTo"} +xref: Orphanet:100077 {source="MONDO:equivalentTo"} +xref: UMLS:CN197357 {source="MONDO:equivalentTo"} +is_a: MONDO:0002564 ! jejunal neoplasm +is_a: MONDO:0002995 {source="MONDO:Redundant", source="NCIT:C135090"} ! small intestine neuroendocrine tumor, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002115 ! jejunum +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197357 +property_value: exactMatch NCIT:C135090 +property_value: exactMatch Orphanet:100077 + +[Term] +id: MONDO:0015065 +name: ileal neuroendocrine tumor, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the ileum." [NCIT:C135092] +comment: Editor note: TODO apply G1/G2 pattern +subset: ordo_disease {source="Orphanet:100078"} +synonym: "ileal neuroendocrine neoplasm" EXACT [Orphanet:100078] +synonym: "ileal neuroendocrine tumor" RELATED [Orphanet:100078] +xref: NCIT:C135092 {source="MONDO:equivalentTo"} +xref: Orphanet:100078 {source="MONDO:equivalentTo"} +xref: UMLS:CN197358 {source="MONDO:equivalentTo"} +is_a: MONDO:0002995 {source="MONDO:Redundant", source="NCIT:C135092"} ! small intestine neuroendocrine tumor, well differentiated, low or intermediate grade +is_a: MONDO:0006801 {source="MONDO:Redundant", source="NCIT:C135092"} ! ileal neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002116 ! ileum +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197358 +property_value: exactMatch NCIT:C135092 +property_value: exactMatch Orphanet:100078 + +[Term] +id: MONDO:0015066 +name: neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the appendix." [NCIT:C96422] +subset: ordo_disease {source="Orphanet:100079"} +synonym: "appendiceal NEN" EXACT [Orphanet:100079] +synonym: "appendiceal neuroendocrine neoplasm" EXACT [Orphanet:100079] +synonym: "appendiceal neuroendocrine tumor" EXACT [Orphanet:100079] +synonym: "appendix NET" EXACT [NCIT:C96422] +synonym: "appendix neuroendocrine tumor" EXACT [NCIT:C96422] +synonym: "appendix well differentiated endocrine tumor" EXACT [NCIT:C96422] +synonym: "appendix well differentiated endocrine tumor/carcinoma" EXACT [NCIT:C96422] +synonym: "NEN of appendix" EXACT [Orphanet:100079] +synonym: "neuroendocrine neoplasm of appendix" RELATED [Orphanet:100079] +synonym: "well-differentiated neuroendocrine tumor of the appendix" RELATED [ONCOTREE:AWDNET] +xref: ICD10CM:C18.1 {source="Orphanet:100079", source="Orphanet:100079/ntbt"} +xref: ICD10CM:D37.3 {source="Orphanet:100079", source="Orphanet:100079/ntbt"} +xref: NCIT:C96422 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:AWDNET {source="MONDO:equivalentTo"} +xref: Orphanet:100079 {source="MONDO:equivalentTo"} +xref: SCTID:725167001 {source="MONDO:equivalentTo"} +is_a: MONDO:0015067 ! neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor +is_a: MONDO:0018511 {source="MONDO:Redundant", source="Orphanet:100079"} ! epithelial tumor of the appendix +is_a: MONDO:0024501 {source="MONDO:Redundant", source="NCIT:C96422"} ! appendix neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://identifiers.org/snomedct/725167001 +property_value: exactMatch NCIT:C96422 +property_value: exactMatch Orphanet:100079 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: narrowMatch https://icd.codes/icd10cm/C18.1 +property_value: narrowMatch https://icd.codes/icd10cm/D37.3 + +[Term] +id: MONDO:0015067 +name: neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the colon." [NCIT:C135212] +subset: ordo_disease {source="Orphanet:100080"} +synonym: "carcinoid tumor of colon" BROAD [MONDO:cjm] +synonym: "colon neuroendocrine tumor" BROAD [NCIT:C135212] +synonym: "colonic NET" EXACT [Orphanet:100080] +synonym: "NET of the colon" EXACT [Orphanet:100080] +synonym: "neuroendocrine neoplasm of the colon" BROAD [Orphanet:100080] +xref: NCIT:C135212 {source="MONDO:equivalentTo"} +is_a: MONDO:0000386 ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0002882 {source="MONDO:Redundant", source="NCIT:C135212"} ! colon neuroendocrine neoplasm +is_a: MONDO:0024479 {source="Orphanet:100080"} ! epithelial tumor of colon +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +relationship: has_modifier MONDO:0021136 {source="MONDO:0018512"} ! rare +property_value: exactMatch NCIT:C135212 + +[Term] +id: MONDO:0015068 +name: neuroendocrine tumor of rectum, well differentiated, low or intermediate grade +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the rectum." [NCIT:C135213] +subset: ordo_disease {source="Orphanet:100081"} +synonym: "neuroendocrine tumor of the rectum" RELATED [Orphanet:100081] +synonym: "rectal neuroendocrine tumor" EXACT [NCIT:C135213, Orphanet:100081] +xref: NCIT:C135213 {source="MONDO:equivalentTo"} +xref: UMLS:CN197361 {source="MONDO:equivalentTo"} +is_a: MONDO:0000386 ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0003646 {source="MONDO:Redundant", source="NCIT:C135213"} ! rectum neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197361 +property_value: exactMatch NCIT:C135213 + +[Term] +id: MONDO:0015069 +name: neuroendocrine tumor of the anal canal +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the anal canal." [NCIT:C96540] +comment: Editor note: TODO apply G1/G2 pattern +subset: ordo_disease {source="Orphanet:100082"} +synonym: "anal canal NET" EXACT [NCIT:C96540] +synonym: "anal canal neuroendocrine neoplasm" BROAD [MONDO:patterns/location] +synonym: "anal canal neuroendocrine tumor" EXACT [NCIT:C96540] +synonym: "anal canal well differentiated tumor" EXACT [NCIT:C96540] +synonym: "anal canal well differentiated tumor/carcinoma" EXACT [NCIT:C96540] +synonym: "anal NET" EXACT [NCIT:C96540] +synonym: "anal Neuroendocrine tumor" EXACT [NCIT:C96540] +synonym: "NET of anal canal" EXACT [Orphanet:100082] +synonym: "NET of the anal canal" EXACT [Orphanet:100082] +synonym: "neuroendocrine neoplasm of the anal canal" EXACT [Orphanet:100082] +synonym: "neuroendocrine tumor of anal canal" RELATED [Orphanet:100082] +xref: NCIT:C96540 {source="MONDO:equivalentTo"} +xref: Orphanet:100082 {source="MONDO:equivalentTo"} +xref: UMLS:CN197362 {source="MONDO:equivalentTo"} +is_a: MONDO:0003504 ! anal canal neuroendocrine neoplasm +is_a: MONDO:0015068 ! neuroendocrine tumor of rectum, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000159 ! anal canal +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197362 +property_value: exactMatch NCIT:C96540 +property_value: exactMatch Orphanet:100082 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0015070 +name: laryngeal neuroendocrine neoplasm +def: "A benign or malignant neoplasm with neuroendocrine differentiation that arises from the larynx. This category includes paraganglioma, carcinoid tumor, small cell carcinoma, and large cell neuroendocrine carcinoma." [NCIT:C6023] +subset: ordo_disease {source="Orphanet:100083"} +synonym: "laryngeal neuroendocrine neoplasm" EXACT [NCIT:C6023] +synonym: "laryngeal neuroendocrine tumor" RELATED [DOID:5457] +synonym: "larynx NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "larynx neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C6023] +synonym: "larynx neuroendocrine tumor" EXACT [MONDO:patterns/location, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "larynx neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of larynx" EXACT [MONDO:patterns/neuroendocrine_neoplasm, NCIT:C6023] +synonym: "neuroendocrine neoplasm of the larynx" EXACT [NCIT:C6023] +synonym: "neuroendocrine tumor of larynx" EXACT [DOID:5457, NCIT:C6023] +xref: DOID:5457 {source="MONDO:equivalentTo"} +xref: NCIT:C6023 {source="DOID:5457", source="MONDO:equivalentTo"} +xref: Orphanet:100083 {source="MONDO:equivalentTo"} +xref: SCTID:707625001 {source="DOID:5457", source="MONDO:equivalentTo"} +xref: UMLS:C1334374 {source="NCIT:C6023", source="DOID:5457", source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="MONDO:0020035-obsoleted"} ! head and neck neoplasm +is_a: MONDO:0019496 {source="DOID:5457", source="MONDO:Redundant", source="NCIT:C6023", source="Orphanet:100083/inferred"} ! neuroendocrine neoplasm +is_a: MONDO:0021071 {source="MONDO:Redundant", source="NCIT:C6023"} ! laryngeal neoplasm +is_a: MONDO:0024623 {source="MONDO:0020035-obsoleted"} ! otorhinolaryngologic disease +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch DOID:5457 +property_value: exactMatch http://identifiers.org/snomedct/707625001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334374 +property_value: exactMatch NCIT:C6023 +property_value: exactMatch Orphanet:100083 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0015071 +name: middle ear neuroendocrine tumor +def: "A neuroendocrine neoplasm that involves the middle ear." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:100084"} +synonym: "middle ear NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "middle ear neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "middle ear neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "middle ear neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of middle ear" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine tumor of middle ear" EXACT [] +xref: Orphanet:100084 {source="MONDO:equivalentTo"} +xref: SCTID:717918002 {source="MONDO:equivalentTo"} +xref: UMLS:C4305468 {source="MONDO:equivalentTo"} +xref: UMLS:CN197364 {source="MONDO:cjm", source="MONDO:equivalentTo"} +is_a: MONDO:0019496 ! neuroendocrine neoplasm +is_a: MONDO:0021366 ! neoplasm of middle ear +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch http://identifiers.org/snomedct/717918002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4305468 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197364 +property_value: exactMatch Orphanet:100084 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0015072 +name: liver neuroendocrine carcinoma +def: "An extremely rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver." [NCIT:C96787] +subset: ordo_disease {source="Orphanet:100085"} +synonym: "hepatic neuroendocrine carcinoma" EXACT [NCIT:C96787] +synonym: "HNEC" EXACT ABBREVIATION [NCIT:C96787] +synonym: "liver neuroendocrine cancer" EXACT [NCIT:C96787] +synonym: "liver neuroendocrine carcinoma" EXACT [MONDO:patterns/location, NCIT:C96787] +synonym: "neuroendocrine carcinoma of liver" EXACT [MONDO:design_pattern] +synonym: "PHNEC" EXACT ABBREVIATION [MONDO:cjm] +synonym: "primary hepatic neuroendocrine carcinoma" EXACT [NCIT:C96787] +synonym: "primary liver neuroendocrine carcinoma" EXACT [NCIT:C96787] +xref: ICD10CM:C22.7 {source="Orphanet:100085/ntbt", source="Orphanet:100085"} +xref: NCIT:C96787 {source="MONDO:equivalentTo"} +xref: Orphanet:100085 {source="MONDO:equivalentTo"} +xref: SCTID:716652006 {source="MONDO:equivalentTo"} +xref: UMLS:C3273031 {source="MONDO:equivalentTo", source="NCIT:C96787"} +xref: UMLS:CN197365 {source="MONDO:equivalentTo"} +is_a: MONDO:0002120 ! neuroendocrine carcinoma +is_a: MONDO:0018531 ! carcinoma of liver and intrahepatic biliary tract +is_a: MONDO:0024503 ! digestive system neuroendocrine neoplasm +intersection_of: MONDO:0002120 ! neuroendocrine carcinoma +intersection_of: disease_has_location UBERON:0002107 ! liver +property_value: exactMatch http://identifiers.org/snomedct/716652006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3273031 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197365 +property_value: exactMatch NCIT:C96787 +property_value: exactMatch Orphanet:100085 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C22.7 + +[Term] +id: MONDO:0015073 +name: gallbladder neuroendocrine tumor, grade 1/2 +def: "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the gallbladder." [NCIT:C96918] +subset: ordo_disease {source="Orphanet:100086"} +synonym: "gallbladder NET" EXACT [NCIT:C96918] +synonym: "gallbladder neuroendocrine tumor" EXACT [NCIT:C96918] +synonym: "gallbladder well differentiated endocrine tumor" EXACT [NCIT:C96918] +synonym: "gallbladder well differentiated endocrine tumor/carcinoma" EXACT [NCIT:C96918] +xref: ICD10CM:C23 {source="Orphanet:100086/ntbt", source="Orphanet:100086"} +xref: NCIT:C96918 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:100086 {source="MONDO:equivalentTo"} +xref: UMLS:C3273116 {source="MONDO:equivalentTo", source="NCIT:C96918"} +xref: UMLS:CN197366 {source="MONDO:equivalentTo"} +is_a: MONDO:0000386 {source="MONDO:Entailed", source="NCIT:C96918"} ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0015509 ! genetic biliary tract disease +is_a: MONDO:0021385 {source="MONDO:0017631-obsoleted"} ! extrahepatic bile duct neoplasm +is_a: MONDO:0024502 {source="MONDO:Redundant", source="NCIT:C96918"} ! gallbladder neuroendocrine neoplasm +intersection_of: MONDO:0024502 ! gallbladder neuroendocrine neoplasm +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3273116 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197366 +property_value: exactMatch NCIT:C96918 +property_value: exactMatch Orphanet:100086 +property_value: narrowMatch https://icd.codes/icd10cm/C23 + +[Term] +id: MONDO:0015074 +name: thyroid tumor +alt_id: MONDO:0021217 +def: "A benign or malignant neoplasm affecting the thyroid gland." [NCIT:P378] +comment: Editor note: TODO +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:100087"} +synonym: "neoplasm of the thyroid" EXACT [NCIT:C3414] +synonym: "neoplasm of the thyroid gland" EXACT [NCIT:C3414] +synonym: "neoplasm of thyroid" EXACT [NCIT:C3414] +synonym: "neoplasm of thyroid gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3414] +synonym: "THYROID" RELATED ABBREVIATION [ONCOTREE:THYROID] +synonym: "thyroid gland neoplasm" EXACT [NCIT:C3414] +synonym: "thyroid gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "thyroid gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3414] +synonym: "thyroid neoplasm" EXACT [NCIT:C3414] +synonym: "thyroid neoplasms" EXACT [NCIT:C3414] +synonym: "thyroid tumor" EXACT [NCIT:C3414] +synonym: "tumor of the thyroid" EXACT [NCIT:C3414] +synonym: "tumor of the thyroid gland" EXACT [NCIT:C3414] +synonym: "tumor of thyroid" EXACT [NCIT:C3414] +synonym: "tumor of thyroid gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3414] +xref: EFO:0003841 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3414 {source="MONDO:equivalentTo"} +xref: ONCOTREE:THYROID {source="MONDO:equivalentTo"} +xref: Orphanet:100087 {source="MONDO:equivalentTo"} +xref: SCTID:127018007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002082 ! endocrine gland neoplasm +is_a: MONDO:0003240 {source="MONDO:Redundant", source="NCIT:C3414"} ! thyroid gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch http://identifiers.org/snomedct/127018007 +property_value: exactMatch NCIT:C3414 +property_value: exactMatch Orphanet:100087 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0015075 +name: thyroid gland carcinoma +def: "A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic." [NCIT:C4815] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:100088"} +synonym: "cancer of the thyroid" BROAD [NCIT:C4815] +synonym: "cancer of thyroid" BROAD [NCIT:C4815] +synonym: "carcinoma of the thyroid" EXACT [NCIT:C4815] +synonym: "carcinoma of the thyroid gland" EXACT [NCIT:C4815] +synonym: "carcinoma of thyroid" EXACT [NCIT:C4815] +synonym: "carcinoma of thyroid gland" EXACT [MONDO:patterns/carcinoma, NCIT:C4815] +synonym: "head and neck cancer, thyroid" BROAD [DOID:3963, NCIT:C4815] +synonym: "thyroid cancer" BROAD [NCIT:C4815] +synonym: "thyroid carcinoma" EXACT [MONDO:ambiguous, NCIT:C4815] +synonym: "thyroid gland cancer" BROAD [NCIT:C4815] +synonym: "thyroid gland carcinoma" EXACT [MONDO:0006461, MONDO:patterns/location, NCIT:C4815] +xref: DOID:3963 {source="MONDO:equivalentTo"} +xref: EFO:1000586 {source="MONDO:equivalentTo"} +xref: HP:0002890 {source="MONDO:otherHierarchy"} +xref: MedDRA:10007476 {source="Orphanet:100088", source="Orphanet:100088/e"} +xref: NCIT:C4815 {source="EFO:1000586", source="MONDO:equivalentTo", source="DOID:3963"} +xref: Orphanet:100088 {source="MONDO:equivalentTo"} +xref: SCTID:448216007 {source="MONDO:equivalentTo"} +xref: UMLS:C0549473 {source="Orphanet:100088", source="NCIT:C4815", source="MONDO:equivalentTo", source="Orphanet:100088/e", source="DOID:3963"} +is_a: MONDO:0002108 {source="DOID:3963", source="MONDO:Redundant", source="NCIT:C4815"} ! thyroid cancer +is_a: MONDO:0004993 {source="DOID:3963", source="EFO:1000586", source="MONDO:Redundant", source="NCIT:C4815/inferred"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: closeMatch http://identifiers.org/meddra/10007476 +property_value: exactMatch DOID:3963 +property_value: exactMatch http://identifiers.org/snomedct/448216007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0549473 +property_value: exactMatch NCIT:C4815 +property_value: exactMatch Orphanet:100088 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0015077 +name: adrenal/paraganglial tumor +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:100091"} +xref: Orphanet:100091 {source="MONDO:equivalentTo"} +xref: UMLS:CN197370 {source="MONDO:equivalentTo"} +is_a: MONDO:0021227 ! adrenal gland neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197370 +property_value: exactMatch Orphanet:100091 +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0015079 +name: multiple polyglandular tumor +comment: Editor note: ORDO classifies as inherited but there are non-inherited forms such as Carney triad +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:100094"} +xref: ICD10WHO:D44.8 {source="Orphanet:100094/specific", source="Orphanet:100094/e", source="MONDO:equivalentTo", source="Orphanet:100094"} +xref: Orphanet:100094 {source="MONDO:equivalentTo"} +xref: UMLS:CN197373 {source="MONDO:equivalentTo"} +is_a: MONDO:0015126 {source="Orphanet:100094"} ! polyendocrinopathy +relationship: disease_has_feature MONDO:0002082 {source="Orphanet:100094"} ! endocrine gland neoplasm +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/D44.8 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197373 +property_value: exactMatch Orphanet:100094 +property_value: excluded_subClassOf MONDO:0025511 {source="Orphanet:100094"} + +[Term] +id: MONDO:0015126 +name: polyendocrinopathy +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:101956"} +xref: ICD10CM:E31.0 {source="Orphanet:101956/btnt", source="Orphanet:101956"} +xref: ICD10CM:E31.1 {source="Orphanet:101956/btnt", source="Orphanet:101956"} +xref: ICD10CM:E31.8 {source="Orphanet:101956/btnt", source="Orphanet:101956"} +xref: ICD10CM:E31.9 {source="Orphanet:101956/btnt", source="Orphanet:101956"} +xref: Orphanet:101956 {source="MONDO:equivalentTo"} +is_a: MONDO:0005151 {source="Orphanet:101956"} ! endocrine system disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0020005"} ! rare +property_value: broadMatch https://icd.codes/icd10cm/E31.1 +property_value: broadMatch https://icd.codes/icd10cm/E31.8 +property_value: broadMatch https://icd.codes/icd10cm/E31.9 +property_value: exactMatch Orphanet:101956 + +[Term] +id: MONDO:0015127 +name: pituitary deficiency +comment: Editor note: in ORDO, Orphanet:101957 is classified as genetic, yet has acquired subtypes +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:101957"} +xref: Orphanet:101957 {source="MONDO:equivalentTo"} +is_a: MONDO:0005151 {source="MONDO:0015889-obsoleted"} ! endocrine system disorder +property_value: exactMatch Orphanet:101957 +property_value: excluded_subClassOf MONDO:0015968 {source="Orphanet:101957"} + +[Term] +id: MONDO:0015133 +name: quantitative and/or qualitative congenital phagocyte defect +comment: Editor note: check how relates to phagocytosis terms +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:101985"} +xref: Orphanet:101985 {source="MONDO:equivalentTo"} +is_a: MONDO:0015135 {source="Orphanet:101985"} ! primary immunodeficiency due to a genetic defect in innate immunity +is_a: MONDO:0024627 ! phagocytic cell dysfunction +relationship: has_modifier MONDO:0021140 {source="https://orcid.org/0000-0002-4142-7153"} ! congenital +property_value: exactMatch Orphanet:101985 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0015135 +name: primary immunodeficiency due to a genetic defect in innate immunity +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:101988"} +synonym: "primary immunodeficiency due to a defect in innate immunity" RELATED [Orphanet:101988] +xref: Orphanet:101988 {source="MONDO:equivalentTo"} +is_a: MONDO:0003778 {source="MONDO:Redundant", source="Orphanet:101988"} ! inborn errors of immunity +intersection_of: MONDO:0003778 ! inborn errors of immunity +intersection_of: disease_has_basis_in_disruption_of GO:0045087 ! innate immune response +relationship: disease_has_basis_in_disruption_of GO:0045087 ! innate immune response +relationship: has_modifier MONDO:0021136 {source="MONDO:0015138"} ! rare +property_value: exactMatch Orphanet:101988 + +[Term] +id: MONDO:0015141 +name: disorder of medulla oblongata +def: "A disease that involves the medulla oblongata." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:102000"} +synonym: "disease of medulla oblongata" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of medulla oblongata" EXACT [] +synonym: "disorder of medulla oblongata" EXACT [MONDO:patterns/location_top] +synonym: "medulla oblongata disease" EXACT [MONDO:design_pattern] +synonym: "medulla oblongata disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "medullar disease" RELATED [Orphanet:102000] +xref: Orphanet:102000 {source="MONDO:equivalentTo"} +xref: UMLS:CN197487 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001896 ! medulla oblongata +relationship: disease_has_location UBERON:0001896 ! medulla oblongata +relationship: has_modifier MONDO:0021136 {source="MONDO:0020009"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197487 +property_value: exactMatch Orphanet:102000 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0015144 +name: brain inflammatory disease +def: "An inflammatory disease involving a pathogenic inflammatory response in the brain." [MONDO:patterns/inflammatory_disease_by_site] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:102005"} +synonym: "brain inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of brain" EXACT [] +xref: Orphanet:102005 {source="MONDO:equivalentTo"} +xref: UMLS:CN197488 {source="MONDO:equivalentTo"} +is_a: MONDO:0005156 ! encephalomyelitis +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000955 ! brain +relationship: disease_has_inflammation_site UBERON:0000955 ! brain +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197488 +property_value: exactMatch Orphanet:102005 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0015175 +name: autoimmune pancreatitis +def: "Autoimmune pancreatitis (AIP) is a rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type 1 AIP which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 AIP which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels." [Orphanet:103919] +subset: ordo_disease {source="Orphanet:103919"} +synonym: "AIP" EXACT ABBREVIATION [Orphanet:103919] +synonym: "lymphoplasmocytic sclerosing pancreatitis" RELATED [GARD:0010911] +xref: DOID:0040091 {source="MONDO:equivalentTo"} +xref: GARD:0010911 {source="MONDO:equivalentTo"} +xref: ICD10CM:K86.1 {source="Orphanet:103919/ntbt", source="Orphanet:103919"} +xref: MedDRA:10069002 {source="Orphanet:103919/e", source="Orphanet:103919"} +xref: Orphanet:103919 {source="MONDO:equivalentTo"} +xref: SCTID:448542008 {source="MONDO:equivalentTo"} +xref: UMLS:C2609129 {source="Orphanet:103919/e", source="DOID:0040091", source="MONDO:equivalentTo", source="Orphanet:103919"} +is_a: MONDO:0000569 {source="DOID:0040091", source="MONDO:Redundant"} ! autoimmune disorder of endocrine system +is_a: MONDO:0000588 ! autoimmune disorder of gastrointestinal tract +is_a: MONDO:0004982 ! pancreatitis +is_a: MONDO:0017287 {source="Orphanet:103919"} ! IgG4-related disease +intersection_of: MONDO:0004982 ! pancreatitis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +relationship: has_modifier MONDO:0021136 {source="MONDO:0015112"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10069002 +property_value: exactMatch DOID:0040091 +property_value: exactMatch http://identifiers.org/snomedct/448542008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2609129 +property_value: exactMatch Orphanet:103919 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml +property_value: narrowMatch https://icd.codes/icd10cm/K86.1 + +[Term] +id: MONDO:0015277 +name: medullary thyroid gland carcinoma +def: "A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy." [NCIT:C3879] +subset: ordo_disease {source="Orphanet:1332"} +synonym: "C cell carcinoma" EXACT [NCIT:C3879] +synonym: "carcinoma of parafollicular cell" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, C-cell, malignant" EXACT [NCIT:C3879] +synonym: "medullary carcinoma" EXACT [NCIT:C3879] +synonym: "medullary carcinoma of the thyroid" EXACT [NCIT:C3879] +synonym: "medullary carcinoma of the thyroid gland" EXACT [DOID:3973, NCIT:C3879] +synonym: "medullary carcinoma of thyroid" EXACT [NCIT:C3879] +synonym: "medullary carcinoma of thyroid gland" EXACT [NCIT:C3879] +synonym: "medullary thyroid cancer" EXACT [NCIT:C3879] +synonym: "medullary thyroid cancer (MTC)" RELATED [GARD:0007004] +synonym: "medullary thyroid carcinoma" EXACT [DOID:3973, MONDO:ambiguous, NCIT:C3879] +synonym: "medullary thyroid gland carcinoma" EXACT [NCIT:C3879] +synonym: "MTC" EXACT ABBREVIATION [NCIT:C3879, Orphanet:1332] +synonym: "parafollicular cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C3879] +synonym: "THME" RELATED ABBREVIATION [ONCOTREE:THME] +synonym: "thyroid cancer, medullary" RELATED [GARD:0007004] +synonym: "thyroid carcinoma, medullary" RELATED [GARD:0007004] +synonym: "thyroid gland medullary cancer" EXACT [NCIT:C3879] +synonym: "thyroid gland medullary carcinoma" EXACT [MONDO:0002823, NCIT:C3879] +synonym: "thyroid gland neuroendocrine carcinoma" EXACT [NCIT:C3879] +synonym: "thyroid medullary carcinoma" EXACT [NCIT:C3879] +synonym: "ultimobranchial thyroid tumor" EXACT [DOID:3973] +synonym: "ultimobranchial thyroid tumour" EXACT [DOID:3973] +xref: DOID:3973 {source="MONDO:equivalentTo"} +xref: GARD:0007004 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: HP:0002865 {source="MONDO:otherHierarchy"} +xref: ICD10CM:C73 {source="Orphanet:1332", source="Orphanet:1332/ntbt"} +xref: MedDRA:10027101 {source="Orphanet:1332", source="Orphanet:1332/e"} +xref: NCIT:C3879 {source="DOID:3973", source="MONDO:equivalentTo"} +xref: ONCOTREE:THME {source="MONDO:equivalentTo"} +xref: Orphanet:1332 {source="MONDO:equivalentTo"} +xref: SCTID:255032005 {source="DOID:3973", source="MONDO:equivalentTo"} +xref: UMLS:C0206693 {source="MONDO:equivalentTo"} +xref: UMLS:C0238462 {source="Orphanet:1332", source="DOID:3973", source="MONDO:equivalentTo", source="Orphanet:1332/e", source="NCIT:C3879"} +is_a: MONDO:0002120 {source="NCIT:C3879"} ! neuroendocrine carcinoma +is_a: MONDO:0005034 {source="DOID:3973"} ! thyroid gland follicular carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0000570 ! parafollicular cell +relationship: disease_arises_from_structure CL:0000570 ! parafollicular cell +relationship: disease_has_location CL:0000570 ! parafollicular cell +property_value: closeMatch http://identifiers.org/meddra/10027101 +property_value: exactMatch DOID:3973 +property_value: exactMatch http://identifiers.org/snomedct/255032005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206693 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238462 +property_value: exactMatch NCIT:C3879 +property_value: exactMatch Orphanet:1332 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C73 + +[Term] +id: MONDO:0015278 +name: familial pancreatic carcinoma +def: "Familial pancreatic carcinoma is defined by the presence of pancreatic cancer (PC) in two or more first-degree relatives." [Orphanet:1333] +subset: clingen +subset: ordo_disease {source="Orphanet:1333"} +synonym: "familial pancreatic cancer" EXACT [NCIT:C43298, Orphanet:1333] +synonym: "familial pancreatic carcinoma" EXACT [NCIT:C43298] +synonym: "hereditary exocrine pancreatic carcinoma" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary pancreatic cancer" EXACT [NCIT:C43298] +synonym: "hereditary pancreatic carcinoma" EXACT [NCIT:C43298] +synonym: "pancreatic acinar carcinoma" RELATED [OMIM:260350] +synonym: "pancreatic cancer, somatic" EXACT [OMIM:260350, OMIM:genemap2] +synonym: "pancreatic carcinoma, somatic" EXACT [OMIM:260350, OMIM:genemap2] +xref: GARD:0004206 {source="MONDO:equivalentTo"} +xref: ICD10CM:C25 {source="Orphanet:1333/inclusion", source="Orphanet:1333/ntbt", source="Orphanet:1333"} +xref: MESH:C535837 {source="Orphanet:1333", source="MONDO:equivalentTo", source="Orphanet:1333/e"} +xref: NCIT:C43298 {source="MONDO:equivalentTo"} +xref: OMIM:260350 {source="Orphanet:1333/ntbt", source="Orphanet:1333", source="MONDO:equivalentTo"} +xref: OMIM:606856 {source="Orphanet:1333/btnt", source="Orphanet:1333"} +xref: OMIM:613347 {source="Orphanet:1333/btnt", source="Orphanet:1333"} +xref: OMIM:613348 {source="Orphanet:1333/btnt", source="Orphanet:1333"} +xref: OMIM:614320 {source="Orphanet:1333/btnt", source="Orphanet:1333"} +xref: Orphanet:1333 {source="MONDO:equivalentTo"} +xref: SCTID:715414009 {source="MONDO:equivalentTo"} +xref: UMLS:C2931038 {source="Orphanet:1333", source="MONDO:equivalentTo", source="NCIT:C43298", source="Orphanet:1333/e"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005192 {source="MONDO:Redundant", source="NCIT:C43298", source="Orphanet:1333"} ! exocrine pancreatic carcinoma +intersection_of: MONDO:0005192 ! exocrine pancreatic carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0015618", source="MONDO:0016314"} ! rare +property_value: exactMatch http://identifiers.org/mesh/C535837 +property_value: exactMatch http://identifiers.org/snomedct/715414009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2931038 +property_value: exactMatch https://omim.org/entry/260350 +property_value: exactMatch NCIT:C43298 +property_value: exactMatch Orphanet:1333 +property_value: narrowMatch https://icd.codes/icd10cm/C25 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0015286 +name: congenital disorder of glycosylation +def: "Congenital disorder of glycosylation (CDG) is a fast growing group of inborn errors of metabolism characterized by defective activity of enzymes that participate in glycosylation (modification of proteins and other macromolecules by adding and processing of oligosaccharide side chains). CDG is comprised of phenotypically diverse disorders affecting multiple systems including the central nervous system, muscle function, immunity, endocrine system, and coagulation. The numerous entities in this group are subdivided, based on the synthetic pathway affected, into disorder of protein N-glycosylation, disorder of protein O-glycosylation, disorder of multiple glycosylation, and disorder of glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation." [Orphanet:137] +subset: clingen +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:137"} +synonym: "carbohydrate deficient glycoprotein syndrome" EXACT [Orphanet:137] +synonym: "carbohydrate-deficient glycoprotein syndrome" EXACT [DOID:5212] +synonym: "carbohydrate-deficient glycoprotein syndromes" RELATED [GARD:0010307] +synonym: "CDG" EXACT ABBREVIATION [Orphanet:137] +synonym: "congenital disorder of glycosylation" EXACT [] +synonym: "congenital disorders of glycosylation" RELATED [GARD:0010307] +xref: DOID:5212 {source="MONDO:equivalentTo"} +xref: GARD:0010307 {source="MONDO:equivalentTo"} +xref: ICD10CM:E77.8 {source="Orphanet:137", source="Orphanet:137/attributed", source="Orphanet:137/ntbt"} +xref: ICD9:271.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D018981 {source="DOID:5212", source="MONDO:equivalentTo"} +xref: NCIT:C84615 {source="DOID:5212", source="MONDO:equivalentTo"} +xref: Orphanet:137 {source="DOID:5212", source="MONDO:equivalentTo"} +xref: SCTID:238049009 {source="DOID:5212", source="MONDO:equivalentTo"} +xref: UMLS:C0282577 {source="DOID:5212", source="Orphanet:137", source="MONDO:equivalentTo", source="Orphanet:137/e"} +is_a: MONDO:0019052 {source="Orphanet:137"} ! inborn errors of metabolism +is_a: MONDO:0024322 ! disorder of glycosylation +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0070085 ! glycosylation +relationship: has_modifier MONDO:0021140 {source="https://orcid.org/0000-0002-4142-7153"} ! congenital +property_value: exactMatch DOID:5212 +property_value: exactMatch http://identifiers.org/mesh/D018981 +property_value: exactMatch http://identifiers.org/snomedct/238049009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0282577 +property_value: exactMatch NCIT:C84615 +property_value: exactMatch Orphanet:137 +property_value: excluded_subClassOf MONDO:0019214 {source="DOID:5212", source="MESH:D018981", source="MONDO:Redundant", source="NCIT:C84615", source="https://github.com/monarch-initiative/mondo/issues/1494", source="https://orcid.org/0000-0001-6330-7526"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E77.8 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0015288 +name: herpes simplex virus keratitis +def: "A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (keratitis, dendritic). (Dictionary of Visual Science, 3d ed)" [MESH:D016849] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:137586"} +synonym: "dendritic keratitis" EXACT [DOID:0080158] +synonym: "herpetic keratitis" EXACT [Orphanet:137586] +synonym: "HSV keratitis" EXACT [Orphanet:137586] +synonym: "Simplexvirus caused keratitis" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Simplexvirus keratitis" EXACT [] +xref: DOID:0080158 {source="MONDO:equivalentTo"} +xref: EFO:0007308 {source="MONDO:equivalentTo"} +xref: ICD10EXP:B00.5+ {source="Orphanet:137586", source="Orphanet:137586/e"} +xref: ICD10EXP:H19.1* {source="Orphanet:137586", source="Orphanet:137586/e"} +xref: NCIT:C34743 {source="MONDO:equivalentTo"} +xref: Orphanet:137586 {source="MONDO:equivalentTo"} +xref: SCTID:9389005 {source="MONDO:equivalentTo"} +xref: UMLS:C0019357 {source="Orphanet:137586", source="MONDO:equivalentTo"} +xref: UMLS:C0022570 {source="MONDO:equivalentTo"} +is_a: MONDO:0004609 ! herpes simplex infectious disease +is_a: MONDO:0020950 ! viral eye infection +is_a: MONDO:0023865 ! corneal infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0000964 ! cornea +intersection_of: MONDO:0100332 NCBITaxon:10294 ! disease has primary infectious agent Simplexvirus +property_value: exactMatch DOID:0080158 +property_value: exactMatch http://identifiers.org/snomedct/9389005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019357 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022570 +property_value: exactMatch NCIT:C34743 +property_value: exactMatch Orphanet:137586 + +[Term] +id: MONDO:0015289 +name: infectious epithelial keratitis +def: "Infectious epithelial keratitis is a rare, potentially sight-threatening, acquired ocular disease chracterized by corneal epithelium inflammation resulting from viral (mainly Herpes Simplex virus), bacterial, fungic or protist infection, manifesting with variable symptoms, such as conjunctival hyperemia, lacrimation, rapid onset of pain, blurred vision and/or photophobia, depending on the causative agent." [Orphanet:137593] +subset: ordo_disease {source="Orphanet:137593"} +xref: Orphanet:137593 {source="MONDO:equivalentTo"} +is_a: MONDO:0020950 {source="MONDO:cjm"} ! viral eye infection +is_a: MONDO:0023865 ! corneal infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001772 ! corneal epithelium +relationship: disease_has_inflammation_site UBERON:0001772 ! corneal epithelium +property_value: exactMatch Orphanet:137593 +property_value: excluded_subClassOf MONDO:0015288 {source="Orphanet:137593"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0015292 +name: endotheliitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the endothelium." [MONDO:patterns/inflammatory_disease_by_site] +subset: ordo_disease {source="Orphanet:137602"} +synonym: "endothelium inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of endothelium" EXACT [] +xref: Orphanet:137602 {source="MONDO:equivalentTo"} +is_a: MONDO:0015288 {source="Orphanet:137602"} ! herpes simplex virus keratitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001986 ! endothelium +relationship: disease_has_inflammation_site UBERON:0001986 ! endothelium +property_value: exactMatch Orphanet:137602 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0015304 +name: arachnoiditis +def: "Arachnoiditis (ARC) is a chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems." [Orphanet:137817] +subset: ordo_disease {source="Orphanet:137817"} +synonym: "adhesive arachnoiditis" EXACT [Orphanet:137817] +synonym: "arachnoid mater inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "chronic arachnoiditis" EXACT [Orphanet:137817] +synonym: "inflammation of arachnoid mater" EXACT [] +xref: DOID:12156 {source="MONDO:equivalentTo"} +xref: GARD:0005839 {source="MONDO:equivalentTo"} +xref: ICD10CM:G03.9 {source="Orphanet:137817", source="Orphanet:137817/ntbt"} +xref: MedDRA:10003074 {source="Orphanet:137817/e", source="Orphanet:137817"} +xref: MESH:D001100 {source="Orphanet:137817/e", source="MONDO:equivalentTo", source="Orphanet:137817", source="DOID:12156"} +xref: NCIT:C37913 {source="MONDO:equivalentTo", source="DOID:12156"} +xref: OMIM:182950 {source="Orphanet:137817", source="Orphanet:137817/btnt"} +xref: Orphanet:137817 {source="MONDO:equivalentTo"} +xref: SCTID:13980006 {source="MONDO:equivalentTo"} +xref: UMLS:C0003708 {source="Orphanet:137817/e", source="MONDO:equivalentTo", source="Orphanet:137817", source="NCIT:C37913", source="DOID:12156"} +xref: UMLS:C0270617 {source="MONDO:equivalentTo", source="Orphanet:137817"} +is_a: MONDO:0004796 {source="DOID:12156", source="MESH:D001100"} ! infectious meningitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002362 ! arachnoid mater +relationship: disease_has_inflammation_site UBERON:0002362 ! arachnoid mater +property_value: closeMatch http://identifiers.org/meddra/10003074 +property_value: exactMatch DOID:12156 +property_value: exactMatch http://identifiers.org/mesh/D001100 +property_value: exactMatch http://identifiers.org/snomedct/13980006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003708 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0270617 +property_value: exactMatch NCIT:C37913 +property_value: exactMatch Orphanet:137817 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: narrowMatch https://icd.codes/icd10cm/G03.9 + +[Term] +id: MONDO:0015327 +name: developmental anomaly of metabolic origin +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:139009"} +xref: Orphanet:139009 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 ! metabolic disease +is_a: MONDO:0019755 {source="MONDO:Redundant", source="Orphanet:139009"} ! developmental defect during embryogenesis +intersection_of: MONDO:0019755 ! developmental defect during embryogenesis +intersection_of: disease_has_basis_in_disruption_of GO:0008152 ! metabolic process +property_value: exactMatch Orphanet:139009 +property_value: excluded_subClassOf MONDO:0015960 {source="Orphanet:139009"} + +[Term] +id: MONDO:0015356 +name: hereditary neoplastic syndrome +def: "The inherited predisposition toward getting a tumor." [NCIT:C3266] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:140162"} +subset: predisposition +synonym: "cancer syndrome, hereditary" EXACT [MESH:D009386] +synonym: "cancer syndromes, hereditary" EXACT [MESH:D009386] +synonym: "familial neoplastic syndrome" EXACT [NCIT:C3266] +synonym: "familial tumor syndrome" EXACT [NCIT:C3266] +synonym: "hereditary cancer syndrome" EXACT [MESH:D009386] +synonym: "hereditary cancer syndromes" EXACT [MESH:D009386] +synonym: "hereditary neoplastic syndrome" EXACT [MESH:D009386, MONDO:patterns/hereditary, NCIT:C3266] +synonym: "hereditary neoplastic syndromes" EXACT [MESH:D009386] +synonym: "hereditary tumor syndrome" EXACT [NCIT:C3266] +synonym: "inherited cancer syndrome" EXACT [NCIT:C3266] +synonym: "inherited cancer-predisposing syndrome" EXACT [Orphanet:140162] +synonym: "neoplastic syndrome, hereditary" EXACT [MESH:D009386] +synonym: "syndrome, hereditary cancer" EXACT [MESH:D009386] +synonym: "syndrome, hereditary neoplastic" EXACT [MESH:D009386] +synonym: "syndromes, hereditary cancer" EXACT [MESH:D009386] +synonym: "syndromes, hereditary neoplastic" EXACT [MESH:D009386] +xref: MESH:D009386 {source="MONDO:equivalentTo"} +xref: NCIT:C3266 {source="MONDO:equivalentTo"} +xref: Orphanet:140162 {source="MONDO:equivalentTo"} +xref: SCTID:699346009 {source="MONDO:equivalentTo"} +xref: UMLS:C0027672 {source="MONDO:equivalentTo", source="NCIT:C3266"} +xref: UMLS:CN199448 {source="MONDO:equivalentTo"} +xref: UMLS:CN882908 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 {source="MESH:D009386", source="MONDO:Redundant", source="NCIT:C3266", source="Orphanet:140162"} ! Mendelian disease +relationship: has_modifier MONDO:0021136 {source="MONDO:0021198"} ! rare +relationship: predisposes_towards MONDO:0005070 {source="https://github.com/monarch-initiative/mondo/issues/1520", source="https://orcid.org/0000-0001-5208-3432"} ! neoplasm +property_value: exactMatch http://identifiers.org/mesh/D009386 +property_value: exactMatch http://identifiers.org/snomedct/699346009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027672 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN199448 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN882908 +property_value: exactMatch NCIT:C3266 +property_value: exactMatch Orphanet:140162 +property_value: excluded_subClassOf MONDO:0021058 {source="MONDO:Redundant", source="NCIT:C3266"} + +[Term] +id: MONDO:0015364 +name: hereditary sensory and autonomic neuropathy +def: "An instance of sensory peripheral neuropathy that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:140471"} +synonym: "CIP" EXACT ABBREVIATION [NCIT:C125386] +synonym: "congenital insensitivity to pain" EXACT [DOID:0050548, NCIT:C125386] +synonym: "congenital pain insensitivity" EXACT [NCIT:C125386] +synonym: "hereditary sensory and autonomic neuropathy" EXACT [DOID:0050548, PMID:15367861] +synonym: "hereditary sensory autonomic neuropathy" RELATED [GARD:0012688] +synonym: "hereditary sensory neuropathy" EXACT [PMID:15367861] +synonym: "hereditary sensory peripheral neuropathy" EXACT [MONDO:patterns/hereditary] +synonym: "HSAN" EXACT ABBREVIATION [MONDO:cjm] +synonym: "indifference to pain, Congenital, autosomal recessive" EXACT [NCIT:C125386] +xref: DOID:0050548 {source="MONDO:equivalentTo"} +xref: GARD:0012688 {source="MONDO:equivalentTo"} +xref: ICD10CM:G60.8 {source="Orphanet:140471", source="Orphanet:140471/attributed", source="Orphanet:140471/ntbt"} +xref: ICD9:356.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009477 {source="Orphanet:140471", source="MONDO:equivalentTo", source="Orphanet:140471/e"} +xref: NCIT:C125386 {source="MONDO:equivalentTo"} +xref: OMIMPS:162400 {source="MONDO:equivalentTo"} +xref: Orphanet:140471 {source="MONDO:equivalentTo"} +xref: SCTID:11442006 {source="MONDO:equivalentTo"} +xref: UMLS:C0027889 {source="Orphanet:140471", source="MONDO:equivalentTo", source="Orphanet:140471/e"} +is_a: MONDO:0002321 {source="MONDO:Redundant"} ! sensory peripheral neuropathy +is_a: MONDO:0020127 {source="MONDO:Redundant", source="Orphanet:140471"} ! genetic peripheral neuropathy +intersection_of: MONDO:0002321 ! sensory peripheral neuropathy +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:0050548 +property_value: exactMatch http://identifiers.org/mesh/D009477 +property_value: exactMatch http://identifiers.org/snomedct/11442006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027889 +property_value: exactMatch https://omim.org/phenotypicSeries/PS162400 +property_value: exactMatch NCIT:C125386 +property_value: exactMatch Orphanet:140471 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: excluded_synonym "familial dysautonomia, type II" xsd:string {source="DOID:0050548"} +property_value: narrowMatch https://icd.codes/icd10cm/G60.8 +property_value: seeAlso https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/25 xsd:anyURI +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0015365 +name: autosomal dominant hereditary sensory and autonomic neuropathy +def: "Autosomal dominant form of hereditary sensory and autonomic neuropathy." [MONDO:patterns/autosomal_dominant] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:140474"} +synonym: "hereditary sensory and autonomic neuropathy, autosomal dominant" EXACT [MONDO:patterns/autosomal_dominant] +xref: ICD10CM:G60.8 {source="Orphanet:140474", source="Orphanet:140474/attributed", source="Orphanet:140474/ntbt"} +xref: Orphanet:140474 {source="MONDO:equivalentTo"} +xref: UMLS:CN228932 {source="MONDO:equivalentTo"} +is_a: MONDO:0000426 ! autosomal dominant disease +is_a: MONDO:0015364 {source="MONDO:Redundant", source="Orphanet:140474"} ! hereditary sensory and autonomic neuropathy +intersection_of: MONDO:0015364 ! hereditary sensory and autonomic neuropathy +intersection_of: has_modifier HP:0000006 ! Autosomal dominant inheritance +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN228932 +property_value: exactMatch Orphanet:140474 +property_value: http://purl.org/dc/terms/conformsTo autosomal:dominant.yaml +property_value: narrowMatch https://icd.codes/icd10cm/G60.8 + +[Term] +id: MONDO:0015447 +name: differentiated thyroid carcinoma +def: "Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass." [Orphanet:146] +subset: ordo_disease {source="Orphanet:146"} +synonym: "differentiated thyroid cancer" EXACT [NCIT:C7153] +synonym: "differentiated thyroid carcinoma" EXACT [NCIT:C7153] +synonym: "differentiated thyroid gland cancer" EXACT [NCIT:C7153] +synonym: "differentiated thyroid gland carcinoma" EXACT [NCIT:C7153] +synonym: "papillary or follicular thyroid carcinoma" EXACT [Orphanet:146] +synonym: "thyroid gland differentiated carcinoma" EXACT [NCIT:C7153] +synonym: "thyroid gland well differentiated carcinoma" EXACT [NCIT:C7153] +synonym: "well differentiated thyroid carcinoma" EXACT [NCIT:C7153] +synonym: "well differentiated thyroid gland carcinoma" EXACT [NCIT:C7153] +synonym: "well-differentiated thyroid cancer" EXACT [NCIT:C7153] +synonym: "well-differentiated thyroid carcinoma" EXACT [Orphanet:146] +xref: DOID:0080525 {source="MONDO:equivalentTo"} +xref: EFO:1002017 {source="MONDO:equivalentTo"} +xref: ICD10CM:C73 {source="Orphanet:146/ntbt", source="Orphanet:146"} +xref: NCIT:C7153 {source="MONDO:equivalentTo"} +xref: OMIM:188550 {source="Orphanet:146/ntbt", source="Orphanet:146"} +xref: OMIM:607464 {source="Orphanet:146/btnt", source="Orphanet:146"} +xref: ONCOTREE:WDTC {source="MONDO:equivalentTo"} +xref: Orphanet:146 {source="MONDO:equivalentTo"} +xref: UMLS:C1337013 {source="NCIT:C7153", source="MONDO:equivalentTo"} +is_a: MONDO:0015075 {source="NCIT:C7153/inferred", source="Orphanet:146"} ! thyroid gland carcinoma +property_value: exactMatch DOID:0080525 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1337013 +property_value: exactMatch NCIT:C7153 +property_value: exactMatch Orphanet:146 +property_value: narrowMatch https://icd.codes/icd10cm/C73 + +[Term] +id: MONDO:0015459 +name: nasopharyngeal carcinoma +def: "A carcinoma arising from the nasopharyngeal epithelium. It includes the following types: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma (differentiated and undifferentiated), basaloid squamous cell carcinoma, and papillary adenocarcinoma." [NCIT:C3871] +subset: ordo_disease {source="Orphanet:150"} +synonym: "cancer of nasopharynx" BROAD [NCIT:C3871] +synonym: "cancer of the nasopharynx" BROAD [NCIT:C3871] +synonym: "carcinoma of nasopharynx" EXACT [DOID:9261, MONDO:patterns/carcinoma, NCIT:C3871] +synonym: "carcinoma of the nasopharynx" EXACT [NCIT:C3871] +synonym: "malignant nasopharyngeal tumor" BROAD [DOID:9261, NCIT:C9321] +synonym: "malignant neoplasm of anterior wall of nasopharynx" BROAD [DOID:9261] +synonym: "malignant neoplasm of lateral wall of nasopharynx" BROAD [DOID:9261] +synonym: "malignant neoplasm of nasopharyngeal wall" BROAD [DOID:9261] +synonym: "malignant neoplasm of nasopharynx" BROAD [DOID:9261, ICD9CM:147, MTH:NOCODE] +synonym: "malignant neoplasm of nasopharynx (disorder) [ambiguous]" BROAD [DOID:9261] +synonym: "malignant neoplasm of other specified sites of nasopharynx" BROAD [DOID:9261] +synonym: "malignant neoplasm of posterior wall of nasopharynx" BROAD [DOID:9261] +synonym: "malignant neoplasm of roof of nasopharynx" BROAD [DOID:9261] +synonym: "malignant neoplasm of superior wall of nasopharynx" BROAD [DOID:9261] +synonym: "malignant tumor of anterior wall of nasopharynx" BROAD [DOID:9261, MTH:U001027] +synonym: "malignant tumor of lateral wall of nasopharynx" BROAD [DOID:9261, MTH:U003238] +synonym: "malignant tumor of posterior wall of nasopharynx" BROAD [DOID:9261, MTH:U001026] +synonym: "nasopharyngeal cancer" BROAD [NCIT:C3871] +synonym: "nasopharyngeal carcinoma" EXACT [DOID:9261, NCIT:C3871] +synonym: "nasopharyngeal throat cancer" BROAD [NCIT:C3871] +synonym: "nasopharynx carcinoma" EXACT [MONDO:patterns/location] +synonym: "NPC" EXACT ABBREVIATION [NCIT:C3871] +synonym: "primary malignant neoplasm of anterior wall of nasopharynx" BROAD [DOID:9261] +synonym: "squamous cell carcinoma of the nasopharynx" EXACT [Orphanet:150] +xref: DOID:9261 {source="MONDO:equivalentTo"} +xref: ICD10CM:C11.0 {source="DOID:9261", source="Orphanet:150", source="Orphanet:150/btnt"} +xref: ICD10CM:C11.1 {source="DOID:9261", source="Orphanet:150", source="Orphanet:150/btnt"} +xref: ICD10CM:C11.2 {source="DOID:9261", source="Orphanet:150", source="Orphanet:150/btnt"} +xref: ICD10CM:C11.3 {source="DOID:9261", source="Orphanet:150", source="Orphanet:150/btnt"} +xref: ICD9:147 {source="DOID:9261"} +xref: ICD9:147.0 {source="DOID:9261"} +xref: ICD9:147.1 {source="DOID:9261"} +xref: ICD9:147.2 {source="DOID:9261", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:147.3 {source="DOID:9261"} +xref: ICD9:147.9 {source="DOID:9261"} +xref: MedDRA:10028793 {source="Orphanet:150", source="Orphanet:150/e"} +xref: MESH:C538339 {source="MONDO:equivalentObsolete", source="Orphanet:150", source="Orphanet:150/e"} +xref: MESH:D00007727 {xref="https://github.com/monarch-initiative/mondo/issues/2068", source="MONDO:equivalentTo"} +xref: NCIT:C3871 {source="MONDO:equivalentTo"} +xref: OMIM:161550 {source="DOID:9261", source="Orphanet:150", source="Orphanet:150/btnt"} +xref: OMIM:617075 {source="Orphanet:150", source="Orphanet:150/btnt"} +xref: ONCOTREE:NPC {source="MONDO:equivalentTo"} +xref: Orphanet:150 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: SCTID:363398003 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: UMLS:C0153393 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: UMLS:C0153394 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: UMLS:C0153395 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: UMLS:C0153396 {source="DOID:9261", source="MONDO:equivalentTo"} +xref: UMLS:C2931822 {source="MONDO:equivalentTo", source="NCIT:C3871", source="Orphanet:150", source="Orphanet:150/e"} +xref: UMLS:C3647449 {source="MONDO:equivalentTo"} +xref: UMLS:C3665551 {source="MONDO:equivalentTo"} +xref: UMLS:CN199582 {source="MONDO:equivalentTo"} +is_a: MONDO:0002038 {source="MONDO:Redundant", source="NCIT:C3871/inferred"} ! head and neck carcinoma +is_a: MONDO:0017344 {source="Orphanet:150"} ! Epstein-Barr virus-associated carcinoma +is_a: MONDO:0021315 {source="MONDO:Redundant", source="NCIT:C3871"} ! malignant tumor of nasopharynx +is_a: MONDO:0021345 {source="MONDO:Redundant", source="NCIT:C3871"} ! carcinoma of pharynx +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001728 ! nasopharynx +relationship: disease_arises_from_structure UBERON:0001951 {source="NCIT:C3871"} ! epithelium of nasopharynx +property_value: broadMatch https://icd.codes/icd10cm/C11.0 +property_value: broadMatch https://icd.codes/icd10cm/C11.1 +property_value: broadMatch https://icd.codes/icd10cm/C11.2 +property_value: broadMatch https://icd.codes/icd10cm/C11.3 +property_value: closeMatch http://identifiers.org/meddra/10028793 +property_value: exactMatch DOID:9261 +property_value: exactMatch http://identifiers.org/mesh/D00007727 +property_value: exactMatch http://identifiers.org/snomedct/363398003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153393 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153394 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153395 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153396 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2931822 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3647449 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3665551 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN199582 +property_value: exactMatch NCIT:C3871 +property_value: exactMatch Orphanet:150 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0015485 +name: primary hereditary glaucoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:156005"} +synonym: "primary glaucoma" RELATED [Orphanet:156005] +xref: Orphanet:156005 {source="MONDO:equivalentTo"} +is_a: MONDO:0018174 {source="Orphanet:156005"} ! hereditary glaucoma +property_value: exactMatch Orphanet:156005 + +[Term] +id: MONDO:0015508 +name: genetic parenchymatous liver disease +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005154 liver disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:156604"} +xref: Orphanet:156604 {source="MONDO:equivalentTo"} +xref: UMLS:CN199641 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005154 {source="MONDO:Redundant", source="Orphanet:156604"} ! liver disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001280 ! liver parenchyma +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: disease_has_location UBERON:0001280 ! liver parenchyma +relationship: has_modifier MONDO:0021136 {source="MONDO:0015114", source="MONDO:0015507"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN199641 +property_value: exactMatch Orphanet:156604 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0015509 +name: genetic biliary tract disease +def: "Genetic biliary tract disease." [] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0004868 biliary tract disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:156607"} +synonym: "genetic biliary tract disease" EXACT [MONDO:patterns/genetic] +xref: Orphanet:156607 {source="MONDO:equivalentTo"} +xref: UMLS:CN199642 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0004868 ! biliary tract disorder +is_a: MONDO:0005154 {source="MONDO:Redundant", source="Orphanet:156607"} ! liver disorder +intersection_of: MONDO:0004868 ! biliary tract disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0015507"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN199642 +property_value: exactMatch Orphanet:156607 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0015512 +name: genetic hypertension +def: "An instance of hypertension that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005044 hypertensive disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:156629"} +synonym: "genetic hypertension" EXACT [MONDO:patterns/genetic] +synonym: "genetic hypertensive disorder" EXACT [MONDO:patterns/genetic] +xref: Orphanet:156629 {source="MONDO:equivalentTo"} +xref: UMLS:C0598428 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005044 {source="MONDO:Redundant", source="Orphanet:156629"} ! hypertensive disorder +is_a: MONDO:0005240 {source="MONDO:0019748-obsoleted"} ! kidney disorder +intersection_of: MONDO:0005044 ! hypertensive disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0020030"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0598428 +property_value: exactMatch Orphanet:156629 +property_value: excluded_subClassOf MONDO:0005240 {source="MONDO:Redundant", source="Orphanet:156629"} +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0015514 +name: genetic endocrine growth disease +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:156643"} +synonym: "growth disorder" EXACT [MONDO:cjm] +xref: MESH:D006130 {source="MONDO:equivalentTo"} +xref: Orphanet:156643 {source="MONDO:equivalentTo"} +xref: UMLS:CN237424 {source="MONDO:equivalentTo"} +is_a: MONDO:0005151 {source="Orphanet:156643"} ! endocrine system disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0015513"} ! rare +property_value: exactMatch http://identifiers.org/mesh/D006130 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237424 +property_value: exactMatch Orphanet:156643 + +[Term] +id: MONDO:0015547 +name: genetic dementia +def: "Genetic dementia." [] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0001627 dementia +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:158124"} +synonym: "genetic dementia" EXACT [MONDO:patterns/genetic] +xref: Orphanet:158124 {source="MONDO:equivalentTo"} +is_a: MONDO:0001627 ! dementia +is_a: MONDO:0019117 {source="MONDO:Redundant", source="Orphanet:158124"} ! genetic nervous system disorder +intersection_of: MONDO:0001627 ! dementia +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch Orphanet:158124 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0015548 +name: Huntington disease-like syndrome +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:158266"} +synonym: "Huntington disease phenocopy syndrome" EXACT [Orphanet:158266] +xref: ICD9:333.99 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:C580174 {source="MONDO:equivalentTo"} +xref: Orphanet:158266 {source="MONDO:equivalentTo"} +xref: SCTID:702376003 {source="MONDO:equivalentTo"} +xref: UMLS:C3711380 {source="Orphanet:158266", source="MONDO:equivalentTo"} +is_a: MONDO:0000167 ! Huntington disease and related disorders +is_a: MONDO:0015547 ! genetic dementia +property_value: exactMatch http://identifiers.org/mesh/C580174 +property_value: exactMatch http://identifiers.org/snomedct/702376003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3711380 +property_value: exactMatch Orphanet:158266 + +[Term] +id: MONDO:0015650 +name: epilepsy syndrome +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:166463"} +synonym: "epileptic syndrome" EXACT [https://github.com/monarch-initiative/mondo/issues/343] +synonym: "syndromic epilepsy" EXACT [MONDO:cjm] +xref: Orphanet:166463 {source="MONDO:equivalentTo"} +is_a: MONDO:0005027 {source="Orphanet:166463"} ! epilepsy +relationship: has_modifier MONDO:0021136 {source="MONDO:0015955"} ! rare +property_value: exactMatch Orphanet:166463 + +[Term] +id: MONDO:0015756 +name: myeloid hemopathy +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:171895"} +xref: Orphanet:171895 {source="MONDO:equivalentTo"} +is_a: MONDO:0019044 {source="Orphanet:171895"} ! tumor of hematopoietic and lymphoid tissues +property_value: exactMatch Orphanet:171895 + +[Term] +id: MONDO:0015757 +name: lymphoid hemopathy +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:171898"} +xref: Orphanet:171898 {source="MONDO:equivalentTo"} +is_a: MONDO:0019044 {source="Orphanet:171898"} ! tumor of hematopoietic and lymphoid tissues +property_value: exactMatch Orphanet:171898 + +[Term] +id: MONDO:0015759 +name: B-cell non-Hodgkin lymphoma +def: "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003" [NCIT:C3457] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:171915"} +synonym: "B-cell lymphoma" EXACT [NCIT:C3457] +synonym: "B-cell NHL" EXACT [Orphanet:171915] +synonym: "B-cell non Hodgkin's lymphoma" EXACT [NCIT:C3457] +synonym: "B-cell non-Hodgkin lymphoma" EXACT [NCIT:C3457] +synonym: "B-cell non-Hodgkin's lymphoma" EXACT [NCIT:C3457] +synonym: "lymphomas non-Hodgkin's B-cell" EXACT [NCIT:C3457] +synonym: "non-Hodgkin's B-cell lymphoma" EXACT [NCIT:C3457] +synonym: "non-Hodgkin's lymphoma B-cell" EXACT [NCIT:C3457] +xref: NCIT:C3457 {source="MONDO:equivalentTo"} +xref: Orphanet:171915 {source="MONDO:equivalentTo"} +is_a: MONDO:0004095 {source="MONDO:Redundant", source="NCIT:C3457"} ! B-cell neoplasm +is_a: MONDO:0018908 {source="MONDO:Redundant", source="NCIT:C3457", source="Orphanet:171915"} ! non-Hodgkin lymphoma +intersection_of: MONDO:0004095 {source="NCIT:C3457"} ! B-cell neoplasm +intersection_of: MONDO:0018908 {source="NCIT:C3457"} ! non-Hodgkin lymphoma +property_value: exactMatch NCIT:C3457 +property_value: exactMatch Orphanet:171915 + +[Term] +id: MONDO:0015770 +name: congenital hypogonadotropic hypogonadism +def: "Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder of sexual maturation characterized by gonadotropin (Gn) deficiency with low sex steroid levels associated with low levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH)." [Orphanet:174590] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:174590"} +xref: ICD10CM:E23.0 {source="Orphanet:174590", source="MONDO:relatedTo", source="Orphanet:174590/attributed", source="Orphanet:174590/ntbt"} +xref: NCIT:C120162 {source="MONDO:equivalentTo"} +xref: Orphanet:174590 {source="MONDO:equivalentTo"} +xref: SCTID:722944006 {source="MONDO:equivalentTo"} +xref: UMLS:C3899503 {source="MONDO:equivalentTo", source="NCIT:C120162"} +is_a: MONDO:0005372 {source="MONDO:0018386-obsoleted", source="MONDO:0018405-obsoleted"} ! male infertility +is_a: MONDO:0016072 {source="MONDO:Redundant", source="Orphanet:174590"} ! anomaly of puberty or/and menstrual cycle of genetic origin +is_a: MONDO:0017143 ! genetic infertility +is_a: MONDO:0018555 {source="NCIT:C120162"} ! hypogonadotropic hypogonadism +is_a: MONDO:0019824 {source="Orphanet:174590"} ! non-acquired pituitary hormone deficiency +is_a: MONDO:0021124 ! female infertility +property_value: exactMatch http://identifiers.org/snomedct/722944006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3899503 +property_value: exactMatch NCIT:C120162 +property_value: exactMatch Orphanet:174590 + +[Term] +id: MONDO:0015823 +name: primary immunodeficiency due to a defect in adaptive immunity +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:179006"} +xref: Orphanet:179006 {source="MONDO:equivalentTo"} +is_a: MONDO:0003778 {source="MONDO:Redundant", source="Orphanet:179006"} ! inborn errors of immunity +intersection_of: MONDO:0003778 ! inborn errors of immunity +intersection_of: disease_has_basis_in_disruption_of GO:0002250 ! adaptive immune response +relationship: disease_has_basis_in_disruption_of GO:0002250 ! adaptive immune response +relationship: has_modifier MONDO:0021136 {source="MONDO:0015138"} ! rare +property_value: exactMatch Orphanet:179006 + +[Term] +id: MONDO:0015860 +name: anomaly of puberty or/and menstrual cycle +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:180208"} +xref: Orphanet:180208 {source="MONDO:equivalentTo"} +is_a: MONDO:0002263 {source="MONDO:0019937-obsoleted"} ! female reproductive system disorder +property_value: exactMatch Orphanet:180208 + +[Term] +id: MONDO:0015867 +name: vaginal carcinoma +def: "A carcinoma arising from the vaginal epithelium. The majority of vaginal carcinomas are squamous cell carcinomas." [NCIT:P378] +subset: ordo_disease {source="Orphanet:180247"} +synonym: "cancer of the vagina" BROAD [NCIT:C3917] +synonym: "cancer of vagina" BROAD [NCIT:C3917] +synonym: "carcinoma of the vagina" EXACT [NCIT:C3917] +synonym: "carcinoma of vagina" EXACT [MONDO:patterns/carcinoma, NCIT:C3917] +synonym: "vagina cancer" BROAD [NCIT:C3917] +synonym: "vagina carcinoma" EXACT [MONDO:patterns/location, NCIT:C3917] +synonym: "vaginal cancer" BROAD [NCIT:C3917] +synonym: "vaginal cancer, NOS" BROAD [NCIT:C3917] +synonym: "vaginal carcinoma" EXACT [NCIT:C3917] +synonym: "vaginal malignant epithelial tumor" BROAD [Orphanet:180247] +xref: DOID:0050918 {source="MONDO:equivalentTo"} +xref: ICD10CM:C52 {source="Orphanet:180247/ntbt", source="Orphanet:180247"} +xref: NCIT:C3917 {source="MONDO:equivalentTo"} +xref: Orphanet:180247 {source="MONDO:equivalentTo"} +xref: UMLS:C0262659 {source="NCIT:C3917", source="Orphanet:180247/e", source="MONDO:equivalentTo", source="Orphanet:180247"} +is_a: MONDO:0001402 {source="DOID:0050918", source="MONDO:Redundant", source="NCIT:C3917"} ! vaginal cancer +is_a: MONDO:0004993 {source="MONDO:Redundant", source="NCIT:C3917"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch DOID:0050918 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0262659 +property_value: exactMatch NCIT:C3917 +property_value: exactMatch Orphanet:180247 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C52 + +[Term] +id: MONDO:0015905 +name: syndromic dyslipidemia +def: "A inherited lipid metabolism disorder that is part of a larger syndrome." [MONDO:patterns/syndromic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:181437"} +synonym: "complex dyslipidemia" EXACT [] +synonym: "rare syndromic dyslipidemia" RELATED [Orphanet:181437] +synonym: "syndrome associated with inherited lipid metabolism disorder" EXACT [MONDO:patterns/syndromic] +synonym: "syndromic inherited lipid metabolism disorder" EXACT [MONDO:patterns/syndromic] +xref: Orphanet:181437 {source="MONDO:equivalentTo"} +xref: SCTID:109041000119107 {source="MONDO:equivalentTo"} +xref: UMLS:C3875286 {source="MONDO:equivalentTo"} +is_a: MONDO:0002254 ! syndromic disease +is_a: MONDO:0002525 {source="MONDO:Redundant", source="Orphanet:181437"} ! inherited lipid metabolism disorder +intersection_of: MONDO:0002525 ! inherited lipid metabolism disorder +intersection_of: has_modifier MONDO:0021127 ! has a syndromic presentation +relationship: has_modifier MONDO:0021136 {source="MONDO:0015123"} ! rare +property_value: exactMatch http://identifiers.org/snomedct/109041000119107 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3875286 +property_value: exactMatch Orphanet:181437 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/syndromic.yaml + +[Term] +id: MONDO:0015923 +name: acquired peripheral neuropathy +def: "An instance of peripheral neuropathy that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:182086"} +synonym: "acquired peripheral neuropathy" EXACT [MONDO:patterns/acquired] +xref: Orphanet:182086 {source="MONDO:equivalentTo"} +is_a: MONDO:0005244 {source="Orphanet:182086"} ! peripheral neuropathy +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021136 {source="MONDO:0020126"} ! rare +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch Orphanet:182086 + +[Term] +id: MONDO:0015925 +name: interstitial lung disease +def: "A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features." [MESH:D017563] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:182095"} +synonym: "ILD" EXACT ABBREVIATION [DOID:3082, Orphanet:182095] +synonym: "interstitial lung disease" EXACT [MONDO:0005370] +xref: DOID:3082 {source="EFO:0004244", source="MONDO:equivalentTo"} +xref: EFO:0004244 {source="MONDO:equivalentTo"} +xref: GARD:0013336 {source="MONDO:equivalentTo"} +xref: ICD10CM:J80-J84 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: MedDRA:10022611 {source="Orphanet:182095", source="Orphanet:182095/e"} +xref: MESH:D017563 {source="EFO:0004244", source="Orphanet:182095", source="MONDO:equivalentTo", source="Orphanet:182095/e", source="DOID:3082"} +xref: Orphanet:182095 {source="MONDO:equivalentTo"} +xref: SCTID:233703007 {source="EFO:0004244", source="MONDO:equivalentTo", source="DOID:3082"} +xref: UMLS:C0206062 {source="Orphanet:182095", source="MONDO:equivalentTo", source="Orphanet:182095/e", source="DOID:3082"} +is_a: MONDO:0005275 {source="DOID:3082", source="EFO:0004244", source="MESH:D017563", source="MONDO:Redundant"} ! lung disorder +relationship: disease_has_location UBERON:0008946 {source="MONDO:cjm"} ! lung parenchyma +property_value: closeMatch http://identifiers.org/meddra/10022611 +property_value: exactMatch DOID:3082 +property_value: exactMatch http://identifiers.org/mesh/D017563 +property_value: exactMatch http://identifiers.org/snomedct/233703007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206062 +property_value: exactMatch https://icd.codes/icd10cm/J80-J84 +property_value: exactMatch Orphanet:182095 + +[Term] +id: MONDO:0015950 +name: inherited skin tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:183487"} +synonym: "genetic skin tumor" RELATED [Orphanet:183487] +xref: Orphanet:183487 {source="MONDO:equivalentTo"} +xref: UMLS:CN200547 {source="MONDO:equivalentTo"} +is_a: MONDO:0002531 ! skin neoplasm +is_a: MONDO:0024255 ! genetic skin disease +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0019041"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200547 +property_value: exactMatch Orphanet:183487 + +[Term] +id: MONDO:0015953 +name: genetic central nervous system and retinal vascular disease +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005071 nervous system disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:183503"} +xref: Orphanet:183503 {source="MONDO:equivalentTo"} +xref: UMLS:CN200550 {source="MONDO:equivalentTo"} +is_a: MONDO:0019117 {source="Orphanet:183503"} ! genetic nervous system disorder +is_a: MONDO:0020676 {source="MONDO:cjm"} ! disorder of central nervous system or retinal vasculature +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0020676 ! disorder of central nervous system or retinal vasculature +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200550 +property_value: exactMatch Orphanet:183503 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0015962 +name: inherited renal tubular disease +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:183592"} +synonym: "genetic renal tubular disease" RELATED [Orphanet:183592] +xref: Orphanet:183592 {source="MONDO:equivalentTo"} +xref: UMLS:CN200561 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0021568 ! renal tubule disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0009773 ! renal tubule +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0020030"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200561 +property_value: exactMatch Orphanet:183592 + +[Term] +id: MONDO:0015978 +name: functional neutrophil defect +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:183681"} +synonym: "neutrophil disease" EXACT [MONDO:cjm] +synonym: "neutrophilopathy" EXACT [MONDO:cjm] +xref: Orphanet:183681 {source="MONDO:equivalentTo"} +xref: SCTID:105600002 {source="MONDO:equivalentTo"} +is_a: MONDO:0015133 {source="Orphanet:183681"} ! quantitative and/or qualitative congenital phagocyte defect +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of CL:0000775 ! neutrophil +relationship: disease_has_basis_in_dysfunction_of CL:0000775 ! neutrophil +property_value: exactMatch http://identifiers.org/snomedct/105600002 +property_value: exactMatch Orphanet:183681 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0015979 +name: hereditary predisposition to infections +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0020573 inherited disease susceptibility +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:183710"} +synonym: "genetic susceptibility to infections due to particular pathogens" EXACT [Orphanet:183710] +xref: ICD10CM:D84.8 {source="Orphanet:183710/attributed", source="Orphanet:183710/ntbt", source="Orphanet:183710"} +xref: Orphanet:183710 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0005550 ! infectious disease +relationship: predisposes_towards MONDO:0005550 ! infectious disease +property_value: exactMatch Orphanet:183710 +property_value: excluded_subClassOf MONDO:0015135 {source="Orphanet:183710"} +property_value: http://purl.org/dc/terms/conformsTo inherited:susceptibility.yaml +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/D84.8 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0016047 +name: endophthalmitis +def: "An infectious process affecting the internal structures of the eye." [NCIT:C34586] +subset: ordo_disease {source="Orphanet:199323"} +xref: DOID:4692 {source="MONDO:equivalentTo"} +xref: ICD10CM:H44.0 {source="Orphanet:199323/btnt", source="Orphanet:199323"} +xref: ICD10CM:H44.1 {source="Orphanet:199323/btnt", source="Orphanet:199323"} +xref: ICD9:360.19 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10014801 {source="Orphanet:199323", source="Orphanet:199323/e"} +xref: MESH:D009877 {source="Orphanet:199323", source="MONDO:equivalentTo", source="Orphanet:199323/e", source="DOID:4692"} +xref: NCIT:C34586 {source="MONDO:equivalentTo", source="DOID:4692"} +xref: Orphanet:199323 {source="MONDO:equivalentTo"} +xref: SCTID:1847009 {source="MONDO:equivalentTo", source="DOID:4692"} +xref: UMLS:C0014236 {source="Orphanet:199323", source="MONDO:equivalentTo", source="NCIT:C34586", source="Orphanet:199323/e", source="DOID:4692"} +is_a: MONDO:0001524 {source="DOID:4692"} ! globe disease +is_a: MONDO:0021166 {source="MONDO:Redundant", source="NCIT:C34586/inferred"} ! inflammatory disease +is_a: MONDO:0043885 ! eye infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0010230 ! eyeball of camera-type eye +relationship: disease_has_inflammation_site UBERON:0010230 ! eyeball of camera-type eye +property_value: broadMatch https://icd.codes/icd10cm/H44.1 +property_value: closeMatch http://identifiers.org/meddra/10014801 +property_value: exactMatch DOID:4692 +property_value: exactMatch http://identifiers.org/mesh/D009877 +property_value: exactMatch http://identifiers.org/snomedct/1847009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014236 +property_value: exactMatch NCIT:C34586 +property_value: exactMatch Orphanet:199323 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0016072 +name: anomaly of puberty or/and menstrual cycle of genetic origin +def: "An instance of anomaly of puberty or/and menstrual cycle that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:202940"} +synonym: "genetic anomaly of puberty or/and menstrual cycle" EXACT [MONDO:patterns/genetic] +xref: Orphanet:202940 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0015860 ! anomaly of puberty or/and menstrual cycle +intersection_of: MONDO:0015860 ! anomaly of puberty or/and menstrual cycle +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0015980"} ! rare +property_value: exactMatch Orphanet:202940 + +[Term] +id: MONDO:0016094 +name: vaginal germ cell malignant tumor +def: "A malignant germ cell tumor that involves the vagina." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:206489"} +synonym: "malignant germ cell tumor of the vagina" RELATED [Orphanet:206489] +synonym: "vagina malignant germ cell tumor" EXACT [MONDO:patterns/location] +synonym: "vaginal germ cell cancer" EXACT [Orphanet:206489] +xref: ICD10CM:C52 {source="Orphanet:206489/ntbt", source="Orphanet:206489"} +xref: Orphanet:206489 {source="MONDO:equivalentTo"} +xref: UMLS:CN200860 {source="MONDO:equivalentTo"} +is_a: MONDO:0001402 ! vaginal cancer +is_a: MONDO:0006290 ! malignant germ cell tumor +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200860 +property_value: exactMatch Orphanet:206489 +property_value: narrowMatch https://icd.codes/icd10cm/C52 + +[Term] +id: MONDO:0016105 +name: acquired skeletal muscle disease +def: "An instance of skeletal muscle disease that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:206638"} +synonym: "acquired skeletal muscle disease" EXACT [MONDO:patterns/acquired] +xref: Orphanet:206638 {source="MONDO:equivalentTo"} +xref: UMLS:CN200878 {source="MONDO:equivalentTo"} +is_a: MONDO:0020120 {source="MONDO:Redundant", source="Orphanet:206638"} ! skeletal muscle disorder +intersection_of: MONDO:0020120 ! skeletal muscle disorder +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200878 +property_value: exactMatch Orphanet:206638 + +[Term] +id: MONDO:0016125 +name: infectious, fungal or parasitic myopathy +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:206988"} +xref: Orphanet:206988 {source="MONDO:equivalentTo"} +is_a: MONDO:0005336 ! myopathy +is_a: MONDO:0005550 ! infectious disease +is_a: MONDO:0016105 {source="Orphanet:206988"} ! acquired skeletal muscle disease +intersection_of: MONDO:0005336 ! myopathy +intersection_of: MONDO:0005550 ! infectious disease +property_value: exactMatch Orphanet:206988 + +[Term] +id: MONDO:0016126 +name: viral myositis +subset: ordo_disease {source="Orphanet:206991"} +xref: ICD10CM:M60.0 {source="Orphanet:206991", source="Orphanet:206991/ntbt"} +xref: ICD9:729.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10051512 {source="Orphanet:206991/e", source="Orphanet:206991"} +xref: Orphanet:206991 {source="MONDO:equivalentTo"} +xref: SCTID:240105009 {source="MONDO:equivalentTo"} +xref: UMLS:C0150005 {source="Orphanet:206991/e", source="MONDO:equivalentTo", source="Orphanet:206991"} +is_a: MONDO:0016125 {source="Orphanet:206991"} ! infectious, fungal or parasitic myopathy +is_a: MONDO:0021167 ! myositis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0002385 ! muscle tissue +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: closeMatch http://identifiers.org/meddra/10051512 +property_value: exactMatch http://identifiers.org/snomedct/240105009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0150005 +property_value: exactMatch Orphanet:206991 +property_value: narrowMatch https://icd.codes/icd10cm/M60.0 + +[Term] +id: MONDO:0016127 +name: bacterial myositis +subset: ordo_disease {source="Orphanet:206994"} +xref: ICD10CM:M60.0 {source="Orphanet:206994/ntbt", source="Orphanet:206994"} +xref: Orphanet:206994 {source="MONDO:equivalentTo"} +xref: SCTID:30330001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 ! bacterial infectious disease +is_a: MONDO:0016125 {source="Orphanet:206994"} ! infectious, fungal or parasitic myopathy +is_a: MONDO:0021167 ! myositis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +intersection_of: disease_has_inflammation_site UBERON:0002385 ! muscle tissue +property_value: exactMatch http://identifiers.org/snomedct/30330001 +property_value: exactMatch Orphanet:206994 +property_value: narrowMatch https://icd.codes/icd10cm/M60.0 + +[Term] +id: MONDO:0016158 +name: narcolepsy-cataplexy syndrome +def: "Narcolepsy with cataplexy is a sleep disorder characterized by excessive day-time sleepiness associated with uncontrollable sleep urges and cataplexy (loss of muscle tone often triggered by pleasant emotions)." [Orphanet:2073] +subset: gard_rare {source="GARD:0007162"} +subset: ordo_disease {source="Orphanet:2073"} +synonym: "GC)lineau disease" EXACT [Orphanet:2073] +synonym: "Gelineau syndrome" RELATED [GARD:0007162] +synonym: "Gelineau's syndrome" RELATED [GARD:0007162] +synonym: "Gélineau disease" EXACT [Orphanet:2073] +synonym: "narcolepsy with cataplexy" EXACT [MONDO:0005069] +synonym: "narcolepsy-cataplexy syndrome" EXACT [GARD:0007162] +synonym: "narcoleptic syndrome" RELATED [GARD:0007162] +synonym: "paroxysmal sleep" RELATED [GARD:0007162] +xref: EFO:0000614 {source="MONDO:equivalentTo"} +xref: GARD:0007162 {source="MONDO:equivalentTo"} +xref: ICD10CM:G47.4 {source="Orphanet:2073/e", source="MONDO:equivalentTo", source="Orphanet:2073"} +xref: ICD10CM:G47.419 {source="DOID:8986", source="MONDO:directSiblingOf"} +xref: ICD9:347.0 {source="DOID:8986", source="EFO:0000614"} +xref: MedDRA:10028713 {source="Orphanet:2073/e", source="Orphanet:2073"} +xref: OMIM:161400 {source="DOID:8986", source="GARD:0007162", source="Orphanet:2073/btnt", source="EFO:0000614", source="Orphanet:2073"} +xref: OMIM:605841 {source="DOID:8986", source="Orphanet:2073/btnt", source="Orphanet:2073"} +xref: OMIM:609039 {source="DOID:8986", source="Orphanet:2073/btnt", source="Orphanet:2073"} +xref: OMIM:612417 {source="DOID:8986", source="Orphanet:2073/btnt", source="Orphanet:2073"} +xref: OMIM:612851 {source="DOID:8986", source="Orphanet:2073/btnt", source="Orphanet:2073"} +xref: OMIM:614223 {source="DOID:8986", source="Orphanet:2073/btnt", source="Orphanet:2073"} +xref: OMIM:614250 {source="DOID:8986", source="Orphanet:2073/btnt", source="EFO:0000614", source="Orphanet:2073"} +xref: Orphanet:2073 {source="DOID:8986", source="GARD:0007162", source="MONDO:equivalentTo"} +is_a: MONDO:0005560 {source="EFO:0000614/inferred"} ! brain disorder +is_a: MONDO:0021107 {source="MONDO:cjm"} ! narcolepsy +relationship: disease_has_feature HP:0002524 ! Cataplexy +property_value: closeMatch http://identifiers.org/meddra/10028713 +property_value: exactMatch https://icd.codes/icd10cm/G47.4 +property_value: exactMatch Orphanet:2073 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/7162/narcolepsy xsd:anyURI {source="GARD:0007162"} + +[Term] +id: MONDO:0016167 +name: optic pathway glioma +def: "Optic pathway glioma (OPG) is a benign tumor that develop along the optic nerve (chiasm, tracts, and radiations) characterized by impairment or loss of vision and may be accompanied by diencephalic symptoms such as reduced growth and alteration in sleeping patterns. OPG are often linked to neurofibromatosis type 1 (NF1)." [Orphanet:2086] +subset: gard_rare {source="GARD:0004107"} +subset: ordo_disease {source="Orphanet:2086"} +synonym: "glioma of optic tract" EXACT [NCIT:C8567] +synonym: "glioma of the optic tract" EXACT [NCIT:C8567] +synonym: "glioma of the visual pathway" EXACT [NCIT:C8567] +synonym: "glioma of visual pathway" EXACT [NCIT:C8567] +synonym: "optic pathway glioma" EXACT [NCIT:C8567] +synonym: "optic tract glioma" EXACT [MONDO:patterns/location, NCIT:C8567] +synonym: "visual pathway glioma" EXACT [NCIT:C8567] +xref: GARD:0004107 {source="MONDO:equivalentTo"} +xref: ICD10CM:D33.3 {source="Orphanet:2086/ntbt", source="Orphanet:2086"} +xref: NCIT:C8567 {source="MONDO:equivalentTo"} +xref: Orphanet:2086 {source="MONDO:equivalentTo"} +xref: UMLS:C0796418 {source="MONDO:equivalentTo", source="NCIT:C8567", source="Orphanet:2086"} +is_a: MONDO:0001834 ! visual pathway disorder +is_a: MONDO:0016749 {source="Orphanet:2086"} ! tumor of cranial and spinal nerves +is_a: MONDO:0017611 ! pituitary tumor +is_a: MONDO:0019833 {source="Orphanet:2086"} ! pituitary hormone deficiency from tumoral origin +is_a: MONDO:0021042 {source="MONDO:Redundant", source="NCIT:C8567"} ! glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: disease_has_location UBERON:0001908 ! optic tract +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0796418 +property_value: exactMatch NCIT:C8567 +property_value: exactMatch Orphanet:2086 +property_value: narrowMatch https://icd.codes/icd10cm/D33.3 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/4107/optic-pathway-glioma xsd:anyURI {source="GARD:0004107"} + +[Term] +id: MONDO:0016169 +name: chronic acquired demyelinating polyneuropathy +def: "Chronic form of acquired peripheral neuropathy." [MONDO:patterns/chronic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:208974"} +synonym: "acquired peripheral neuropathy, chronic" EXACT [MONDO:design_pattern, MONDO:patterns/chronic] +synonym: "CADP" EXACT ABBREVIATION [Orphanet:208974] +synonym: "chronic acquired peripheral neuropathy" EXACT [MONDO:design_pattern] +xref: Orphanet:208974 {source="MONDO:equivalentTo"} +is_a: MONDO:0015923 {source="MONDO:Redundant", source="Orphanet:208974"} ! acquired peripheral neuropathy +intersection_of: MONDO:0015923 ! acquired peripheral neuropathy +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch Orphanet:208974 + +[Term] +id: MONDO:0016172 +name: acquired sensory ganglionopathy +def: "An instance of sensory ganglionopathy that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:208984"} +synonym: "acquired sensory ganglionopathy" EXACT [MONDO:patterns/acquired] +synonym: "acquired sensory neuronopathy" EXACT [Orphanet:208984] +xref: Orphanet:208984 {source="MONDO:equivalentTo"} +is_a: MONDO:0015923 {source="Orphanet:208984"} ! acquired peripheral neuropathy +is_a: MONDO:0021260 {source="MONDO:Redundant", source="MONDO:cjm"} ! sensory ganglionopathy +intersection_of: MONDO:0021260 ! sensory ganglionopathy +intersection_of: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch Orphanet:208984 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml + +[Term] +id: MONDO:0016174 +name: paraneoplastic sensory ganglionopathy +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:208999"} +synonym: "paraneoplastic sensory neuronopathy" EXACT [Orphanet:208999] +xref: Orphanet:208999 {source="MONDO:equivalentTo"} +is_a: MONDO:0016172 {source="MONDO:Redundant", source="Orphanet:208999"} ! acquired sensory ganglionopathy +is_a: MONDO:0018215 ! paraneoplastic neurologic syndrome +intersection_of: MONDO:0016172 ! acquired sensory ganglionopathy +intersection_of: MONDO:0021073 ! paraneoplastic syndrome +property_value: exactMatch Orphanet:208999 + +[Term] +id: MONDO:0016248 +name: familial ovarian cancer +def: "An instance of ovarian cancer that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:213517"} +synonym: "familial ovarian cancer" EXACT [] +synonym: "familial ovarian carcinoma" EXACT [NCIT:C36102] +synonym: "familial ovarian malignant tumor" EXACT [Orphanet:213517] +synonym: "familiar ovarian carcinoma" RELATED [DOID:6901] +synonym: "hereditary ovarian cancer" EXACT [MONDO:patterns/hereditary, NCIT:C36102] +synonym: "hereditary ovarian carcinoma" EXACT [MONDO:patterns/hereditary, NCIT:C36102] +xref: DOID:6901 {source="MONDO:equivalentTo"} +xref: ICD10CM:C56 {source="Orphanet:213517", source="Orphanet:213517/attributed", source="Orphanet:213517/ntbt"} +xref: NCIT:C36102 {source="DOID:6901", source="MONDO:equivalentTo"} +xref: Orphanet:213517 {source="MONDO:equivalentTo"} +xref: UMLS:C1333992 {source="DOID:6901", source="MONDO:equivalentTo", source="NCIT:C36102"} +xref: UMLS:CN201036 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005140 {source="MONDO:Redundant", source="NCIT:C36102"} ! ovarian carcinoma +intersection_of: MONDO:0008170 ! ovarian cancer +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:6901 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333992 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201036 +property_value: exactMatch NCIT:C36102 +property_value: exactMatch Orphanet:213517 +property_value: excluded_subClassOf MONDO:0015981 {source="MONDO:Entailed", source="Orphanet:213517"} +property_value: excluded_subClassOf MONDO:0018365 {source="Orphanet:213517"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C56 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4889 + +[Term] +id: MONDO:0016264 +name: autoimmune hepatitis +def: "Hepatitis caused by autoantibodies. Drugs, infections, and toxins may trigger the production of the autoantibodies against the liver parenchyma." [NCIT:C27029] +subset: gard_rare +subset: ordo_disease {source="Orphanet:2137"} +synonym: "AIH" RELATED ABBREVIATION [GARD:0005871] +synonym: "autoimmune chronic active hepatitis" EXACT [DOID:2048, https://emedicine.medscape.com/article/172356-overview#a3] +synonym: "autoimmune chronic hepatitis" RELATED [GARD:0005871] +synonym: "autoimmune hepatitis" EXACT [DOID:2048, NCIT:C27029] +synonym: "autoimmune hepatitis with centrilobular necrosis" EXACT [DOID:2048] +synonym: "autoimmune liver disease" BROAD [https://emedicine.medscape.com/article/172356-overview#a3] +synonym: "chronic autoimmune hepatitis" EXACT [Orphanet:2137] +xref: DOID:2048 {source="EFO:0005676", source="MONDO:equivalentTo"} +xref: EFO:0005676 {source="MONDO:equivalentTo"} +xref: GARD:0005871 {source="MONDO:equivalentTo"} +xref: ICD10CM:K75.4 {source="DOID:2048", source="Orphanet:2137", source="MONDO:equivalentTo", source="Orphanet:2137/e"} +xref: ICD9:571.42 {source="EFO:0005676", source="DOID:2048", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10003827 {source="Orphanet:2137", source="Orphanet:2137/e"} +xref: MESH:D019693 {source="DOID:2048", source="MONDO:equivalentTo"} +xref: NCIT:C27029 {source="EFO:0005676", source="DOID:2048", source="MONDO:equivalentTo"} +xref: Orphanet:2137 {source="MONDO:equivalentTo"} +xref: SCTID:408335007 {source="EFO:0005676", source="DOID:2048", source="MONDO:equivalentTo"} +xref: UMLS:C0241910 {source="DOID:2048", source="Orphanet:2137", source="MONDO:equivalentTo", source="NCIT:C27029", source="Orphanet:2137/e", source="GARD:0005871"} +xref: UMLS:C1332355 {source="DOID:2048", source="MONDO:equivalentTo"} +is_a: MONDO:0000569 ! autoimmune disorder of endocrine system +is_a: MONDO:0000586 ! autoimmune disorder of exocrine system +is_a: MONDO:0000588 {source="DOID:2048", source="MONDO:Entailed"} ! autoimmune disorder of gastrointestinal tract +is_a: MONDO:0002251 {source="MESH:D019693/inferred", source="MONDO:Redundant", source="NCIT:C27029"} ! hepatitis +intersection_of: MONDO:0002251 ! hepatitis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +relationship: has_modifier MONDO:0021136 {source="MONDO:0015114"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10003827 +property_value: exactMatch DOID:2048 +property_value: exactMatch http://identifiers.org/mesh/D019693 +property_value: exactMatch http://identifiers.org/snomedct/408335007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0241910 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332355 +property_value: exactMatch https://icd.codes/icd10cm/K75.4 +property_value: exactMatch NCIT:C27029 +property_value: exactMatch Orphanet:2137 + +[Term] +id: MONDO:0016289 +name: malignant germ cell tumor of cervix uteri +def: "A malignant germ cell tumor that involves the uterine cervix." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:213837"} +synonym: "cervical germ cell cancer" EXACT [Orphanet:213837] +synonym: "cervical malignant germ cell tumor" EXACT [Orphanet:213837] +synonym: "germ cell cancer of cervix uteri" EXACT [Orphanet:213837] +synonym: "germ cell cancer of the cervix uteri" EXACT [Orphanet:213837] +synonym: "malignant germ cell tumor of the cervix uteri" RELATED [Orphanet:213837] +synonym: "uterine cervix malignant germ cell tumor" EXACT [MONDO:patterns/location] +xref: ICD10CM:C53.0 {source="MONDO:relatedTo", source="Orphanet:213837/btnt", source="Orphanet:213837"} +xref: ICD10CM:C53.1 {source="Orphanet:213837/btnt", source="Orphanet:213837"} +xref: ICD10CM:C53.8 {source="Orphanet:213837/btnt", source="Orphanet:213837"} +xref: Orphanet:213837 {source="MONDO:equivalentTo"} +xref: UMLS:CN201079 {source="MONDO:equivalentTo"} +is_a: MONDO:0002974 {source="Orphanet:213837"} ! cervical cancer +is_a: MONDO:0006290 ! malignant germ cell tumor +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +relationship: has_modifier MONDO:0021136 {source="MONDO:0016274"} ! rare +property_value: broadMatch https://icd.codes/icd10cm/C53.1 +property_value: broadMatch https://icd.codes/icd10cm/C53.8 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201079 +property_value: exactMatch Orphanet:213837 + +[Term] +id: MONDO:0016367 +name: dermatomyositis +def: "Dermatomyositis (DM) is a type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness." [Orphanet:221] +subset: gard_rare +subset: ordo_disease {source="Orphanet:221"} +synonym: "adult dermatomyositis" NARROW [GARD:0006263, Orphanet:221] +synonym: "Amyopathic dermatomyositis" RELATED [DOID:10223, MESH:C538250] +synonym: "dermatomyositis" EXACT [MONDO:0005014] +synonym: "dermatopolymyositis" EXACT [DOID:10223] +synonym: "DM" EXACT ABBREVIATION [Orphanet:221] +synonym: "polymyositis with skin involvement" EXACT [DOID:10223] +xref: DOID:10223 {source="EFO:0000398", source="MONDO:equivalentTo"} +xref: EFO:0000398 {source="MONDO:equivalentTo"} +xref: GARD:0006263 {source="MONDO:equivalentTo"} +xref: ICD10CM:M33.0 {source="Orphanet:221/ntbt", source="Orphanet:221"} +xref: ICD10CM:M33.1 {source="Orphanet:221/ntbt", source="Orphanet:221"} +xref: ICD9:710.3 {source="EFO:0000398", source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:10223"} +xref: MedDRA:10012503 {source="Orphanet:221/e", source="Orphanet:221"} +xref: MESH:D003882 {source="Orphanet:221/e", source="EFO:0000398", source="MONDO:equivalentTo", source="Orphanet:221", source="DOID:10223"} +xref: NCIT:C26744 {source="EFO:0000398", source="MONDO:equivalentTo", source="DOID:10223"} +xref: Orphanet:221 {source="MONDO:equivalentTo", source="GARD:0006263"} +xref: SCTID:396230008 {source="EFO:0000398", source="MONDO:equivalentTo", source="DOID:10223"} +xref: UMLS:C0011633 {source="Orphanet:221/e", source="MONDO:equivalentTo", source="NCIT:C26744", source="Orphanet:221", source="DOID:10223"} +is_a: MONDO:0002406 ! dermatitis +is_a: MONDO:0005554 {source="https://orcid.org/0000-0002-0736-9199"} ! rheumatic disorder +is_a: MONDO:0019127 {source="MESH:D003882"} ! polymyositis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000014 ! zone of skin +intersection_of: disease_has_inflammation_site UBERON:0002385 ! muscle tissue +relationship: disease_has_location UBERON:0001015 {source="EFO:0000784"} ! musculature +property_value: closeMatch http://identifiers.org/meddra/10012503 +property_value: exactMatch DOID:10223 +property_value: exactMatch http://identifiers.org/mesh/D003882 +property_value: exactMatch http://identifiers.org/snomedct/396230008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011633 +property_value: exactMatch NCIT:C26744 +property_value: exactMatch Orphanet:221 +property_value: excluded_subClassOf MONDO:0003900 {source="MESH:D003882"} +property_value: excluded_subClassOf MONDO:0017368 {source="Orphanet:221"} +property_value: excluded_subClassOf MONDO:0019724 {source="Orphanet:221"} +property_value: narrowMatch https://icd.codes/icd10cm/M33.0 +property_value: narrowMatch https://icd.codes/icd10cm/M33.1 + +[Term] +id: MONDO:0016372 +name: glossopharyngeal neuralgia +def: "Glossopharyngeal neuralgia is a condition characterized by repeated episodes of severe pain in the tongue, throat, ear, and tonsils (areas connected to the ninth cranial nerve, or glossopharyngeal nerve). It typically occurs in individuals over age 40. Episodes of pain may last from a few seconds to a few minutes, and usually occur on one side. The pain may be triggered by swallowing, speaking, laughing, chewing or coughing. The condition is thought to be due to irritation of the nerve, although the source of irritation is unclear. The goal of treatment is to control pain, but over-the-counter pain medications are not very effective; the most effective drugs are anti-seizure medications. Some antidepressants help certain people. Surgery to cut or take pressure off of the glossopharyngeal nerve may be needed in severe cases." [https://rarediseases.info.nih.gov/diseases/6519/glossopharyngeal-neuralgia] +subset: gard_rare {source="GARD:0006519"} +subset: ordo_disease {source="Orphanet:221098"} +synonym: "glossopharyngeal nerve neuralgia" EXACT [MONDO:patterns/location] +synonym: "glossopharyngeal neuralgia" EXACT [DOID:14423, ICD9CM:352.1] +synonym: "Glossovasopharyngeal neuralgia" EXACT [Orphanet:221098] +synonym: "neuralgia of glossopharyngeal nerve" EXACT [MONDO:design_pattern] +xref: DOID:14423 {source="MONDO:equivalentTo"} +xref: GARD:0006519 {source="MONDO:equivalentTo"} +xref: ICD10CM:G52.1 {source="Orphanet:221098", source="Orphanet:221098/ntbt", source="DOID:14423"} +xref: ICD9:352.1 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:14423"} +xref: MedDRA:10018391 {source="Orphanet:221098", source="Orphanet:221098/e"} +xref: Orphanet:221098 {source="MONDO:equivalentTo"} +xref: SCTID:43763009 {source="MONDO:equivalentTo", source="DOID:14423"} +xref: UMLS:C0154731 {source="Orphanet:221098", source="MONDO:equivalentTo", source="Orphanet:221098/e", source="DOID:14423"} +is_a: MONDO:0002639 {source="DOID:14423", source="MONDO:Redundant"} ! glossopharyngeal nerve disorder +is_a: MONDO:0016374 {source="MONDO:Redundant", source="Orphanet:221098"} ! cranial neuralgia +intersection_of: MONDO:0021667 ! neuralgia +intersection_of: disease_has_location UBERON:0001649 ! glossopharyngeal nerve +property_value: closeMatch http://identifiers.org/meddra/10018391 +property_value: exactMatch DOID:14423 +property_value: exactMatch http://identifiers.org/snomedct/43763009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154731 +property_value: exactMatch Orphanet:221098 +property_value: narrowMatch https://icd.codes/icd10cm/G52.1 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6519/glossopharyngeal-neuralgia xsd:anyURI {source="GARD:0006519"} + +[Term] +id: MONDO:0016374 +name: cranial neuralgia +def: "A neuralgia that involves the cranial neuron projection bundle." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:221109"} +synonym: "cranial neuron projection bundle neuralgia" EXACT [MONDO:patterns/location] +synonym: "facial neuralgia" NARROW [Orphanet:221109] +synonym: "neuralgia of cranial neuron projection bundle" EXACT [MONDO:design_pattern] +xref: Orphanet:221109 {source="MONDO:equivalentTo"} +xref: SCTID:23096007 {source="MONDO:equivalentTo"} +xref: UMLS:C0010269 {source="Orphanet:221109/e", source="MONDO:equivalentTo", source="Orphanet:221109"} +is_a: MONDO:0003569 {source="MONDO:Redundant"} ! cranial nerve neuropathy +is_a: MONDO:0015923 {source="Orphanet:221109"} ! acquired peripheral neuropathy +is_a: MONDO:0021667 ! neuralgia +intersection_of: MONDO:0021667 ! neuralgia +intersection_of: disease_has_location UBERON:0034713 ! cranial neuron projection bundle +property_value: exactMatch http://identifiers.org/snomedct/23096007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010269 +property_value: exactMatch Orphanet:221109 + +[Term] +id: MONDO:0016387 +name: mitochondrial oxidative phosphorylation disorder +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:223713"} +synonym: "OXPHOS disease" EXACT [Orphanet:223713] +synonym: "OXPHOS system deficiency" EXACT [doi:10.1136/jmg.2006.042168] +xref: Orphanet:223713 {source="MONDO:equivalentTo"} +xref: UMLS:CN201288 {source="MONDO:equivalentTo"} +is_a: MONDO:0004069 {source="MONDO:Redundant", source="Orphanet:223713"} ! inborn mitochondrial metabolism disorder +is_a: MONDO:0019254 ! inborn disorder of purine or pyrimidine metabolism +intersection_of: MONDO:0004069 ! inborn mitochondrial metabolism disorder +intersection_of: disease_disrupts GO:0006119 ! oxidative phosphorylation +relationship: disease_disrupts GO:0006119 ! oxidative phosphorylation +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201288 +property_value: exactMatch Orphanet:223713 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0016419 +name: hereditary breast carcinoma +def: "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." [NCIT:P378] +comment: Editor note: check w clingen before merge https://github.com/monarch-initiative/mondo/issues/84 +subset: clingen +subset: ordo_disease {source="Orphanet:227535"} +synonym: "breast cancer susceptibility, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, familial" RELATED [OMIM:114480] +synonym: "breast cancer, familial Male" RELATED [OMIM:114480] +synonym: "breast cancer, invasive ductal, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, lobular, somatic" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, protection against, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, somatic" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "breast cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:114480, OMIM:genemap2] +synonym: "familial breast cancer" EXACT [Orphanet:227535] +synonym: "familial breast carcinoma" EXACT [NCIT:C4503, Orphanet:227535] +synonym: "familial cancer of breast" EXACT [NCIT:C4503] +synonym: "familial cancer of the breast" EXACT [NCIT:C4503] +synonym: "hereditary breast cancer" EXACT [NCIT:C4503] +synonym: "hereditary breast carcinoma" EXACT [MONDO:patterns/hereditary, NCIT:C4503, Orphanet:227535] +xref: ICD10CM:C50.0 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: ICD10CM:C50.1 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: ICD10CM:C50.2 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="MONDO:relatedTo", source="Orphanet:227535"} +xref: ICD10CM:C50.3 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="MONDO:relatedTo", source="Orphanet:227535"} +xref: ICD10CM:C50.4 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: ICD10CM:C50.5 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: ICD10CM:C50.6 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="MONDO:relatedTo", source="Orphanet:227535"} +xref: ICD10CM:C50.8 {source="Orphanet:227535/attributed", source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: MESH:C562840 {source="MONDO:equivalentTo"} +xref: NCIT:C4503 {source="MONDO:equivalentTo"} +xref: OMIM:114480 {source="Orphanet:227535/ntbt", source="Orphanet:227535", source="MONDO:equivalentTo"} +xref: OMIM:600048 {source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: OMIM:604370 {source="Orphanet:227535/ntbt", source="Orphanet:227535"} +xref: OMIM:605365 {source="Orphanet:227535/btnt", source="Orphanet:227535"} +xref: OMIM:612555 {source="Orphanet:227535/ntbt", source="Orphanet:227535"} +xref: OMIM:613399 {source="Orphanet:227535/ntbt", source="Orphanet:227535"} +xref: Orphanet:227535 {source="MONDO:equivalentTo"} +xref: SCTID:254843006 {source="MONDO:equivalentTo"} +xref: UMLS:C0346153 {source="Orphanet:227535", source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="NCIT:C4503"} +is_a: MONDO:0003847 {source="MONDO:Redundant", source="Orphanet:227535/inferred"} ! Mendelian disease +is_a: MONDO:0004989 ! breast carcinoma +intersection_of: MONDO:0004989 ! breast carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: disease_has_feature MONDO:0004989 {source="MONDO:cjm", source="NCIT:C4503"} ! breast carcinoma +property_value: broadMatch https://icd.codes/icd10cm/C50.0 +property_value: broadMatch https://icd.codes/icd10cm/C50.1 +property_value: broadMatch https://icd.codes/icd10cm/C50.4 +property_value: broadMatch https://icd.codes/icd10cm/C50.5 +property_value: broadMatch https://icd.codes/icd10cm/C50.8 +property_value: exactMatch http://identifiers.org/mesh/C562840 +property_value: exactMatch http://identifiers.org/snomedct/254843006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346153 +property_value: exactMatch https://omim.org/entry/114480 +property_value: exactMatch NCIT:C4503 +property_value: exactMatch Orphanet:227535 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0016474 +name: drug-induced lupus erythematosus +def: "An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs." [NCIT:C114354] +subset: ordo_disease {source="Orphanet:231111"} +synonym: "DIL" BROAD ABBREVIATION [DOID:0040093] +synonym: "DILE" EXACT ABBREVIATION [DOID:0040093, Orphanet:231111] +synonym: "drug induced lupus" EXACT [NCIT:C114354] +synonym: "drug induced lupus erythematosus" EXACT [NCIT:C114354] +synonym: "drug-induced lupus" EXACT [NCIT:C114354] +xref: DOID:0040093 {source="MONDO:equivalentTo"} +xref: MedDRA:10013706 {source="Orphanet:231111", source="Orphanet:231111/e"} +xref: NCIT:C114354 {source="MONDO:equivalentTo"} +xref: Orphanet:231111 {source="MONDO:equivalentTo"} +xref: SCTID:80258006 {source="MONDO:equivalentTo"} +xref: UMLS:C0263591 {source="Orphanet:231111", source="MONDO:equivalentTo", source="NCIT:C114354", source="DOID:0040093", source="Orphanet:231111/e"} +is_a: MONDO:0004670 {source="DOID:0040093", source="MONDO:Redundant", source="NCIT:C114354"} ! lupus erythematosus +intersection_of: MONDO:0004670 ! lupus erythematosus +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: closeMatch http://identifiers.org/meddra/10013706 +property_value: exactMatch DOID:0040093 +property_value: exactMatch http://identifiers.org/snomedct/80258006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0263591 +property_value: exactMatch NCIT:C114354 +property_value: exactMatch Orphanet:231111 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/realized_in_response_to_environmental_exposure.yaml + +[Term] +id: MONDO:0016593 +name: acquired ataxia +def: "A type of ataxia that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:247242"} +synonym: "acquired ataxia" EXACT [MONDO:patterns/acquired] +xref: Orphanet:247242 {source="MONDO:equivalentTo"} +xref: SCTID:722968003 {source="MONDO:equivalentTo"} +is_a: MONDO:0100308 {source="https://orcid.org/0000-0002-0736-9199"} ! atactic disorder +intersection_of: MONDO:0100308 ! atactic disorder +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: disease_has_feature HP:0001251 {source="https://orcid.org/0000-0001-5208-3432"} ! Ataxia +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://identifiers.org/snomedct/722968003 +property_value: exactMatch Orphanet:247242 +property_value: excluded_subClassOf MONDO:0000437 {source="Orphanet:247242"} + +[Term] +id: MONDO:0016642 +name: meningioma +def: "A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)" [NCIT:C3230] +subset: ordo_disease {source="Orphanet:2495"} +synonym: "intracranial meningioma" EXACT [DOID:3565] +synonym: "meningeal neoplasm" RELATED [DOID:3565] +synonym: "meningioma" EXACT [MONDO:ambiguous, NCIT:C3230] +synonym: "meningioma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "meningothelial cell tumor" RELATED [DOID:3565] +synonym: "primary meningeal tumor" RELATED [DOID:3565] +synonym: "supratentorial meningioma" RELATED [DOID:3565] +xref: DOID:3565 {source="MONDO:equivalentTo"} +xref: GARD:0007015 {source="MONDO:equivalentTo"} +xref: HP:0002858 {source="MONDO:otherHierarchy"} +xref: ICD10CM:D32.9 {source="Orphanet:2495", source="Orphanet:2495/ntbt", source="DOID:3565"} +xref: ICDO:9530/0 {source="NCIT:C3230"} +xref: MedDRA:10027191 {source="Orphanet:2495", source="Orphanet:2495/e"} +xref: MESH:D008579 {source="Orphanet:2495", source="DOID:3565", source="MONDO:equivalentTo", source="Orphanet:2495/e"} +xref: NCIT:C3230 {source="DOID:3565", source="MONDO:equivalentTo"} +xref: OMIM:606190 {source="Orphanet:2495", source="Orphanet:2495/btnt"} +xref: ONCOTREE:MNG {source="MONDO:equivalentTo"} +xref: Orphanet:2495 {source="MONDO:equivalentTo"} +xref: SCTID:302820008 {source="DOID:3565", source="MONDO:equivalentTo"} +xref: UMLS:C0025286 {source="Orphanet:2495", source="DOID:3565", source="NCIT:C3230", source="MONDO:equivalentTo", source="Orphanet:2495/e"} +is_a: MONDO:0016743 {source="NCIT:C3230", source="ONCOTREE:MNG", source="Orphanet:2495"} ! tumor of meninges +property_value: closeMatch http://identifiers.org/meddra/10027191 +property_value: exactMatch DOID:3565 +property_value: exactMatch http://identifiers.org/mesh/D008579 +property_value: exactMatch http://identifiers.org/snomedct/302820008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025286 +property_value: exactMatch NCIT:C3230 +property_value: exactMatch Orphanet:2495 +property_value: IAO:0000589 "meningioma (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/D32.9 + +[Term] +id: MONDO:0016664 +name: drug-induced vasculitis +def: "A skin hypersensitivity reaction due to exposure to a pharmacologic substance that is characterized by raised purpuric lesions, red macules, hemorrhagic blisters and ulcerations." [NCIT:P378] +subset: ordo_disease {source="Orphanet:251325"} +synonym: "drug induced cutaneous vasculitis" EXACT [NCIT:C112204] +synonym: "drug induced vasculitis" EXACT [NCIT:C112204] +xref: ICD10CM:M31.8 {source="Orphanet:251325/ntbt", source="Orphanet:251325"} +xref: NCIT:C112204 {source="MONDO:equivalentTo"} +xref: Orphanet:251325 {source="MONDO:equivalentTo"} +xref: UMLS:C3812646 {source="MONDO:equivalentTo", source="NCIT:C112204"} +is_a: MONDO:0018640 {source="MONDO:Redundant", source="Orphanet:251325"} ! secondary vasculitis +intersection_of: MONDO:0018640 ! secondary vasculitis +intersection_of: realized_in_response_to ECTO:0000509 ! exposure to drug +relationship: realized_in_response_to ECTO:0000509 ! exposure to drug +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3812646 +property_value: exactMatch NCIT:C112204 +property_value: exactMatch Orphanet:251325 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/realized_in_response_to_environmental_exposure.yaml +property_value: narrowMatch https://icd.codes/icd10cm/M31.8 + +[Term] +id: MONDO:0016680 +name: high grade astrocytic tumor +def: "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)." [NCIT:C102897] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:251561"} +synonym: "high grade astrocytic neoplasm" EXACT [NCIT:C102897] +synonym: "high grade astrocytic tumor" EXACT [NCIT:C102897] +synonym: "high-grade astrocytic neoplasm" EXACT [NCIT:C102897] +synonym: "high-grade astrocytic tumor" EXACT [NCIT:C102897] +synonym: "high-grade astrocytoma" RELATED [Orphanet:251561] +xref: NCIT:C102897 {source="MONDO:equivalentTo"} +xref: Orphanet:251561 {source="MONDO:equivalentTo"} +xref: UMLS:C3640999 {source="MONDO:equivalentTo", source="NCIT:C102897"} +is_a: MONDO:0021636 {source="NCIT:C102897", source="Orphanet:251561"} ! astrocytic tumor +is_a: MONDO:0100342 {source="NCIT:C102897", source="Orphanet:251561/inferred"} ! malignant glioma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3640999 +property_value: exactMatch NCIT:C102897 +property_value: exactMatch Orphanet:251561 + +[Term] +id: MONDO:0016685 +name: low-grade astrocytoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:251592"} +xref: MedDRA:10065869 {source="Orphanet:251592", source="Orphanet:251592/e"} +xref: Orphanet:251592 {source="MONDO:equivalentTo"} +is_a: MONDO:0019781 {source="MONDO:Redundant", source="Orphanet:251592"} ! astrocytoma (excluding glioblastoma) +is_a: MONDO:0021638 ! low grade astrocytic tumor +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: closeMatch http://identifiers.org/meddra/10065869 +property_value: exactMatch Orphanet:251592 + +[Term] +id: MONDO:0016697 +name: low grade ependymoma +subset: ordo_disease {source="Orphanet:251633"} +xref: ICD10CM:D43.2 {source="Orphanet:251633/ntbt", source="Orphanet:251633"} +xref: Orphanet:251633 {source="MONDO:equivalentTo"} +xref: UMLS:CN201940 {source="MONDO:equivalentTo"} +is_a: MONDO:0016698 {source="MONDO:Redundant"} ! ependymoma +intersection_of: MONDO:0016698 ! ependymoma +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +relationship: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201940 +property_value: exactMatch Orphanet:251633 +property_value: narrowMatch https://icd.codes/icd10cm/D43.2 + +[Term] +id: MONDO:0016698 +name: ependymoma +def: "A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)" [NCIT:C3017] +subset: ordo_histopathological_subtype {source="Orphanet:251636"} +synonym: "benign ependymoma" EXACT [DOID:4844, MONDO:0003161] +synonym: "clear cell ependymoma (histologic variant)" RELATED [GARD:0006353] +synonym: "ependymoma" EXACT [NCIT:C3017] +synonym: "ependymoma, benign" NARROW [MONDO:patterns/benign] +synonym: "ependymoma, familial" RELATED [GARD:0006353] +synonym: "epithelial ependymoma" EXACT [DOID:4844] +synonym: "papillary ependymoma (histologic variant)" RELATED [GARD:0006353] +synonym: "tanycytic ependymoma (histologic variant)" RELATED [GARD:0006353] +synonym: "WHO grade II ependymal neoplasm" NARROW [NCIT:C3017] +synonym: "WHO grade II ependymal tumor" NARROW [DOID:4844, NCIT:C3017] +xref: DOID:4844 {source="MONDO:equivalentTo"} +xref: GARD:0006353 {source="MONDO:equivalentTo"} +xref: ICD10CM:D43.2 {source="Orphanet:251636/ntbt", source="Orphanet:251636"} +xref: ICDO:9391/3 {source="NCIT:C3017"} +xref: MedDRA:10014967 {source="Orphanet:251636/e", source="Orphanet:251636"} +xref: MESH:D004806 {source="DOID:4844", source="MONDO:equivalentTo"} +xref: NCIT:C3017 {source="ONCOTREE:EPM", source="DOID:4844", source="MONDO:equivalentTo"} +xref: ONCOTREE:EPM {source="MONDO:equivalentTo"} +xref: Orphanet:251636 {source="MONDO:equivalentTo", source="UMLS:CN201941"} +xref: UMLS:C0014474 {source="ONCOTREE:EPM", source="Orphanet:251636/e", source="DOID:4844", source="MONDO:equivalentTo", source="NCIT:C3017", source="Orphanet:251636"} +xref: UMLS:CN201941 {source="MONDO:equivalentTo"} +is_a: MONDO:0003266 {source="MONDO:Redundant", source="NCIT:C3017", source="ONCOTREE:EPM", source="Orphanet:251636/inferred"} ! ependymal tumor +is_a: MONDO:0021639 {source="MONDO:Redundant", source="NCIT:C3017"} ! grade II glioma +intersection_of: MONDO:0003266 {source="NCIT:C3017"} ! ependymal tumor +intersection_of: has_modifier MONDO:0024492 {source="NCIT:C3017"} ! tumor grade 2, general grading system +property_value: closeMatch http://identifiers.org/meddra/10014967 +property_value: exactMatch DOID:4844 +property_value: exactMatch http://identifiers.org/mesh/D004806 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014474 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201941 +property_value: exactMatch NCIT:C3017 +property_value: exactMatch Orphanet:251636 +property_value: excluded_subClassOf MONDO:0000638 {source="DOID:4844", source="MONDO:Entailed", source="MONDO:Redundant"} +property_value: excluded_subClassOf MONDO:0016697 {source="UMLS:CN201941"} +property_value: narrowMatch https://icd.codes/icd10cm/D43.2 + +[Term] +id: MONDO:0016708 +name: embryonal tumor of neuroepithelial tissue +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:251852"} +xref: Orphanet:251852 {source="MONDO:equivalentTo"} +xref: UMLS:CN201955 {source="MONDO:equivalentTo"} +is_a: MONDO:0005564 ! embryonal neoplasm +is_a: MONDO:0021193 {source="Orphanet:251852"} ! neuroepithelial neoplasm +intersection_of: MONDO:0005564 ! embryonal neoplasm +intersection_of: disease_arises_from_structure UBERON:0034705 ! developing neuroepithelium +relationship: has_modifier MONDO:0021136 {source="MONDO:0016679"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201955 +property_value: exactMatch Orphanet:251852 + +[Term] +id: MONDO:0016717 +name: choroid plexus neoplasm +alt_id: MONDO:0021226 +def: "An intraventricular papillary neoplasm that originates from the choroid plexus epithelium. It includes the choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma." [NCIT:C3473] +comment: Editor note: see ticket on ncit tracker +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:251896"} +synonym: "choroid plexus neoplasm" EXACT [NCIT:C3473] +synonym: "choroid plexus tumor" EXACT [NCIT:C3473] +synonym: "neoplasm of choroid plexus" EXACT [NCIT:C3473] +synonym: "neoplasm of the choroid plexus" EXACT [NCIT:C3473] +synonym: "tumor of choroid plexus" EXACT [NCIT:C3473] +synonym: "tumor of the choroid plexus" EXACT [NCIT:C3473] +xref: NCIT:C3473 {source="MONDO:equivalentTo"} +xref: ONCOTREE:CPT {source="MONDO:equivalentTo"} +xref: Orphanet:251896 {source="MONDO:equivalentTo"} +xref: SCTID:254942002 {source="MONDO:equivalentTo"} +xref: UMLS:C0085138 {source="NCIT:C3473", source="MONDO:equivalentTo", source="Orphanet:251896", source="Orphanet:251896/e"} +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C3473/inferred"} ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure UBERON:0003911 ! choroid plexus epithelium +relationship: disease_arises_from_structure UBERON:0003911 {source="NCIT:C3473"} ! choroid plexus epithelium +relationship: disease_has_location UBERON:0004086 {source="NCIT:C3473"} ! brain ventricle +property_value: exactMatch http://identifiers.org/snomedct/254942002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085138 +property_value: exactMatch NCIT:C3473 +property_value: exactMatch Orphanet:251896 + +[Term] +id: MONDO:0016718 +name: choroid plexus carcinoma +def: "A malignant neoplasm arising from the choroid plexus. It shows anaplastic features and usually invades neighboring brain structures. Cerebrospinal fluid metastases are frequent. (Adapted from WHO)" [NCIT:C4715] +subset: ordo_disease {source="Orphanet:251899"} +synonym: "anaplastic choroid plexus papilloma" EXACT [NCIT:C4715] +synonym: "cancer of choroid plexus" BROAD [DOID:5648, NCIT:C4715] +synonym: "cancer of the choroid plexus" BROAD [NCIT:C4715] +synonym: "carcinoma of choroid plexus" EXACT [NCIT:C4715] +synonym: "carcinoma of the choroid plexus" EXACT [NCIT:C4715] +synonym: "carcinoma, choroid plexus, malignant" EXACT [NCIT:C4715] +synonym: "choroid plexus cancer" BROAD [NCIT:C4715] +synonym: "choroid plexus carcinoma" EXACT [NCIT:C4715] +synonym: "choroid plexus carcinoma (morphologic abnormality)" EXACT [DOID:5648] +synonym: "malignant neoplasm of choroid plexus" BROAD [DOID:5648] +synonym: "malignant neoplasm of the choroid plexus" BROAD [DOID:5648, NCIT:C4533] +synonym: "malignant tumor of choroid plexus" BROAD [DOID:5648] +xref: DOID:5648 {source="MONDO:equivalentTo"} +xref: GARD:0008238 {source="MONDO:equivalentTo"} +xref: ICD10CM:C71.7 {source="Orphanet:251899/ntbt", source="Orphanet:251899"} +xref: ICDO:9390/3 {source="NCIT:C4715"} +xref: MedDRA:10067478 {source="Orphanet:251899/e", source="Orphanet:251899"} +xref: MESH:C562943 {source="MONDO:equivalentTo", source="DOID:5648"} +xref: NCIT:C4715 {source="MONDO:equivalentTo", source="DOID:5648"} +xref: OMIM:260500 {source="Orphanet:251899/ntbt", source="MONDO:directSiblingOf", source="Orphanet:251899"} +xref: ONCOTREE:CPC {source="MONDO:equivalentTo"} +xref: Orphanet:251899 {source="MONDO:equivalentTo"} +xref: SCTID:188292007 {source="MONDO:equivalentTo", source="DOID:5648"} +is_a: MONDO:0002681 {source="DOID:5648", source="MONDO:Redundant", source="NCIT:C4715"} ! choroid plexus cancer +is_a: MONDO:0004993 {source="DOID:5648", source="MESH:C562943", source="MONDO:Redundant", source="NCIT:C4715/inferred"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure UBERON:0003911 ! choroid plexus epithelium +intersection_of: disease_has_location UBERON:0001886 ! choroid plexus +property_value: closeMatch http://identifiers.org/meddra/10067478 +property_value: exactMatch DOID:5648 +property_value: exactMatch http://identifiers.org/mesh/C562943 +property_value: exactMatch http://identifiers.org/snomedct/188292007 +property_value: exactMatch NCIT:C4715 +property_value: exactMatch Orphanet:251899 +property_value: narrowMatch https://icd.codes/icd10cm/C71.7 + +[Term] +id: MONDO:0016743 +name: tumor of meninges +def: "A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions." [NCIT:C3229] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:252025"} +synonym: "meningeal cluster neoplasm" EXACT [] +synonym: "meningeal cluster neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "meningeal cluster rare nervous system tumor" EXACT [MONDO:patterns/location] +synonym: "meningeal cluster tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "meningeal neoplasm" EXACT [NCIT:C3229] +synonym: "meningeal neoplasms" EXACT [NCIT:C3229] +synonym: "meningeal tumor" EXACT [NCIT:C3229] +synonym: "meninges neoplasm" EXACT [NCIT:C3229] +synonym: "meninges tumor" EXACT [NCIT:C3229] +synonym: "meningothelial tumor" RELATED [ONCOTREE:MNGT] +synonym: "neoplasm of meningeal cluster" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of meninges" EXACT [NCIT:C3229] +synonym: "neoplasm of the meninges" EXACT [NCIT:C3229] +synonym: "tumor of meningeal cluster" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of meninges" EXACT [NCIT:C3229] +synonym: "tumor of the meninges" EXACT [NCIT:C3229] +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10061282 {source="Orphanet:252025", source="Orphanet:252025/e"} +xref: NCIT:C3229 {source="MONDO:equivalentTo"} +xref: ONCOTREE:MNGT {source="MONDO:equivalentTo"} +xref: Orphanet:252025 {source="MONDO:equivalentTo"} +xref: SCTID:126965008 {source="MONDO:equivalentTo"} +xref: UMLS:C0025284 {source="MONDO:equivalentTo", source="Orphanet:252025", source="Orphanet:252025/e", source="NCIT:C3229"} +is_a: MONDO:0006130 ! central nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0010743 ! meningeal cluster +relationship: disease_has_location UBERON:0010743 ! meningeal cluster +relationship: has_modifier MONDO:0021136 {source="MONDO:0020036"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10061282 +property_value: exactMatch http://identifiers.org/snomedct/126965008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025284 +property_value: exactMatch NCIT:C3229 +property_value: exactMatch Orphanet:252025 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0016749 +name: tumor of cranial and spinal nerves +subset: disease_grouping +subset: gard_rare {source="GARD:0012697"} +subset: ordo_group_of_disorders {source="Orphanet:252057"} +synonym: "rare tumor of cranial and spinal nerves" EXACT [Orphanet:252057] +xref: GARD:0012697 {source="MONDO:equivalentTo"} +xref: Orphanet:252057 {source="MONDO:equivalentTo"} +xref: UMLS:CN201996 {source="MONDO:equivalentTo"} +is_a: MONDO:0021248 {source="Orphanet:252057"} ! nervous system neoplasm +relationship: has_modifier MONDO:0021136 {source="MONDO:0020036"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN201996 +property_value: exactMatch Orphanet:252057 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/12697/tumor-of-cranial-and-spinal-nerves xsd:anyURI {source="GARD:0012697"} + +[Term] +id: MONDO:0016752 +name: benign peripheral nerve sheath tumor +comment: Editor note: consider relationship to granular cell tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:252131"} +synonym: "BPNST" EXACT ABBREVIATION [Orphanet:252131] +xref: Orphanet:252131 {source="MONDO:equivalentTo"} +xref: UMLS:CN202000 {source="MONDO:equivalentTo"} +is_a: MONDO:0016749 {source="Orphanet:252131"} ! tumor of cranial and spinal nerves +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202000 +property_value: exactMatch Orphanet:252131 + +[Term] +id: MONDO:0016789 +name: pyruvate metabolism disorder +def: "An acquired metabolic disease that is has its basis in the disruption of pyruvate metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:254746"} +synonym: "inborn error of pyruvate metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn pyruvate metabolic process disorder" EXACT [] +synonym: "rare inborn error of pyruvate metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E74.4 {source="Orphanet:254746/attributed", source="Orphanet:254746/ntbt", source="Orphanet:254746"} +xref: Orphanet:254746 {source="MONDO:equivalentTo"} +xref: UMLS:CN226999 {source="MONDO:equivalentTo"} +is_a: MONDO:0000688 ! inherited organic acidemia +is_a: MONDO:0019243 {source="Orphanet:254746"} ! inborn disorder of energy metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006090 ! pyruvate metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006090 ! pyruvate metabolic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN226999 +property_value: exactMatch Orphanet:254746 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E74.4 + +[Term] +id: MONDO:0016790 +name: tricarboxylic acid cycle disorder +def: "An acquired metabolic disease that is has its basis in the disruption of tricarboxylic acid cycle." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:254749"} +synonym: "citric acid cycle disorder" EXACT [Orphanet:254749] +synonym: "inborn error of tricarboxylic acid cycle" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn tricarboxylic acid cycle disorder" EXACT [] +synonym: "Krebs cycle disorder" EXACT [Orphanet:254749] +synonym: "rare inborn error of tricarboxylic acid cycle" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "TCA cycle disorder" EXACT [Orphanet:254749] +xref: ICD10CM:E88.8 {source="Orphanet:254749/attributed", source="Orphanet:254749/ntbt", source="Orphanet:254749"} +xref: Orphanet:254749 {source="MONDO:equivalentTo"} +xref: UMLS:CN227000 {source="MONDO:equivalentTo"} +is_a: MONDO:0019243 {source="MONDO:Redundant", source="Orphanet:254749"} ! inborn disorder of energy metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006099 ! tricarboxylic acid cycle +relationship: disease_has_basis_in_disruption_of GO:0006099 ! tricarboxylic acid cycle +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227000 +property_value: exactMatch Orphanet:254749 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E88.8 + +[Term] +id: MONDO:0017014 +name: interstitial lung disease specific to childhood +def: "A interstitial lung disease that occurs during childhood." [MONDO:design_pattern] +comment: The terms chILD or chILD syndrome (not preferred) have been coined to memorize easily and to identify a phenotype that requires prompt and expert evaluation. +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:264656"} +synonym: "chILD" EXACT [PMID:23905526] +synonym: "chILD syndrome" EXACT [PMID:23905526] +synonym: "childhood interstitial lung disease" EXACT [] +synonym: "ILD specific to childhood" EXACT [Orphanet:264656] +synonym: "interstitial lung disease of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric interstitial lung disease" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: Orphanet:264656 {source="MONDO:equivalentTo"} +xref: SCTID:328661000119108 {source="MONDO:equivalentTo"} +xref: UMLS:CN202324 {source="MONDO:equivalentTo"} +is_a: MONDO:0015925 {source="MONDO:Redundant", source="Orphanet:264656"} ! interstitial lung disease +intersection_of: MONDO:0015925 ! interstitial lung disease +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://identifiers.org/snomedct/328661000119108 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202324 +property_value: exactMatch Orphanet:264656 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4389 xsd:string + +[Term] +id: MONDO:0017030 +name: interstitial lung disease in childhood and adulthood +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0015925 interstitial lung disease +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:264757"} +synonym: "ILD in childhood and adulthood" EXACT [Orphanet:264757] +xref: Orphanet:264757 {source="MONDO:equivalentTo"} +xref: UMLS:CN202341 {source="MONDO:equivalentTo"} +is_a: MONDO:0015925 {source="Orphanet:264757"} ! interstitial lung disease +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202341 +property_value: exactMatch Orphanet:264757 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0017034 +name: secondary interstitial lung disease in childhood and adulthood +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0015925 interstitial lung disease +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:264944"} +synonym: "secondary ILD in childhood and adulthood" EXACT [Orphanet:264944] +xref: Orphanet:264944 {source="MONDO:equivalentTo"} +xref: UMLS:CN202346 {source="MONDO:equivalentTo"} +is_a: MONDO:0017030 {source="Orphanet:264944"} ! interstitial lung disease in childhood and adulthood +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202346 +property_value: exactMatch Orphanet:264944 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0017040 +name: exposure-related interstitial lung disease +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0015925 interstitial lung disease +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:264984"} +xref: Orphanet:264984 {source="MONDO:equivalentTo"} +xref: UMLS:CN202351 {source="MONDO:equivalentTo"} +is_a: MONDO:0017034 {source="Orphanet:264984"} ! secondary interstitial lung disease in childhood and adulthood +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202351 +property_value: exactMatch Orphanet:264984 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0017059 +name: neural tube closure defect +def: "A disease that has its basis in the disruption of neural tube closure." [MONDO:design_pattern] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:268357"} +synonym: "disorder of neural tube closure" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "neural tube closure disease" EXACT [MONDO:design_pattern] +xref: OMIM:182940 {source="Orphanet:268357", source="Orphanet:268357/btnt"} +xref: OMIM:301410 {source="Orphanet:268357", source="Orphanet:268357/btnt"} +xref: OMIM:601634 {source="Orphanet:268357", source="Orphanet:268357/btnt"} +xref: Orphanet:268357 {source="MONDO:equivalentTo"} +is_a: MONDO:0018075 {source="Orphanet:268357"} ! neural tube defect +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0001843 ! neural tube closure +relationship: disease_has_basis_in_disruption_of GO:0001843 ! neural tube closure +property_value: exactMatch Orphanet:268357 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0017127 +name: inherited soft tissue tumor +def: "An instance of mesenchymal cell neoplasm that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:271832"} +synonym: "genetic mesenchymal cell neoplasm" EXACT [MONDO:patterns/genetic] +synonym: "genetic mesenchymal tumor" EXACT [Orphanet:271832] +synonym: "genetic soft tissue tumor" RELATED [Orphanet:271832] +synonym: "hereditary mesenchymal cell neoplasm" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:271832 {source="MONDO:equivalentTo"} +xref: UMLS:CN202526 {source="MONDO:equivalentTo"} +is_a: MONDO:0002616 {source="MONDO:Redundant", source="Orphanet:271832"} ! mesenchymal cell neoplasm +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0002616 ! mesenchymal cell neoplasm +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0019041"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202526 +property_value: exactMatch Orphanet:271832 + +[Term] +id: MONDO:0017128 +name: inherited digestive tract tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:271835"} +synonym: "genetic digestive tract tumor" RELATED [Orphanet:271835] +xref: Orphanet:271835 {source="MONDO:equivalentTo"} +xref: UMLS:CN202527 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001555 ! digestive tract +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: disease_has_location UBERON:0001555 ! digestive tract +relationship: has_modifier MONDO:0021136 {source="MONDO:0019041"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202527 +property_value: exactMatch Orphanet:271835 + +[Term] +id: MONDO:0017129 +name: inherited cardiac tumor +def: "An instance of heart cancer that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:271841"} +synonym: "genetic cardiac tumor" RELATED [Orphanet:271841] +synonym: "genetic heart tumor" EXACT [Orphanet:271841] +synonym: "hereditary heart neoplasm" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:271841 {source="MONDO:equivalentTo"} +xref: UMLS:CN202528 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0021209 ! heart neoplasm +intersection_of: MONDO:0021209 ! heart neoplasm +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0019041"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202528 +property_value: exactMatch Orphanet:271841 + +[Term] +id: MONDO:0017143 +name: genetic infertility +def: "Genetic infertility." [] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005047 infertility disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:275742"} +synonym: "genetic infertility" EXACT [MONDO:patterns/genetic] +synonym: "hereditary infertility disorder" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:275742 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005047 {source="MONDO:Redundant", source="Orphanet:275742"} ! infertility disorder +intersection_of: MONDO:0005047 ! infertility disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch Orphanet:275742 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0017167 +name: malignant epithelial tumor of salivary glands +subset: ordo_disease {source="Orphanet:276145"} +synonym: "malignant epithelial tumor of the salivary glands" RELATED [Orphanet:276145] +xref: ICD10CM:C07 {source="Orphanet:276145", source="Orphanet:276145/btnt"} +xref: ICD10CM:C08.0 {source="Orphanet:276145", source="Orphanet:276145/btnt"} +xref: ICD10CM:C08.1 {source="Orphanet:276145", source="Orphanet:276145/btnt"} +xref: Orphanet:276145 {source="MONDO:equivalentTo"} +xref: UMLS:CN202591 {source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="MONDO:0017166-obsoleted"} ! head and neck neoplasm +is_a: MONDO:0021223 {source="MONDO:0017166-obsoleted"} ! digestive system neoplasm +property_value: broadMatch https://icd.codes/icd10cm/C07 +property_value: broadMatch https://icd.codes/icd10cm/C08.0 +property_value: broadMatch https://icd.codes/icd10cm/C08.1 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202591 +property_value: exactMatch Orphanet:276145 + +[Term] +id: MONDO:0017169 +name: multiple endocrine neoplasia +def: "Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs." [Orphanet:276161] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:276161"} +synonym: "men" EXACT [NCIT:C6432, Orphanet:276161] +synonym: "men syndrome" EXACT [NCIT:C6432] +synonym: "men syndromes" EXACT [NCIT:C6432] +synonym: "multiple endocrine adenomatosis" EXACT [NCIT:C6432] +synonym: "multiple endocrine neoplasia" EXACT [NCIT:C6432] +synonym: "multiple endocrine neoplasia syndrome" EXACT [NCIT:C6432] +synonym: "multiple endocrine neoplasia syndrome(s)" EXACT [NCIT:C6432] +xref: ICD10CM:D44.8 {source="Orphanet:276161/ntbt", source="Orphanet:276161/inclusion", source="Orphanet:276161"} +xref: ICD9:258.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICDO:8360/1 {source="NCIT:C6432"} +xref: MedDRA:10061299 {source="Orphanet:276161/e", source="Orphanet:276161"} +xref: MESH:D009377 {source="MONDO:equivalentTo"} +xref: NCIT:C6432 {source="MONDO:equivalentTo"} +xref: OMIMPS:131100 {source="MONDO:equivalentTo"} +xref: Orphanet:276161 {source="MONDO:equivalentTo"} +xref: SCTID:46724008 {source="MONDO:equivalentTo"} +xref: UMLS:C0027662 {source="Orphanet:276161/e", source="NCIT:C6432", source="MONDO:equivalentTo", source="Orphanet:276161"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0015079 {source="Orphanet:276161"} ! multiple polyglandular tumor +is_a: MONDO:0021058 {source="NCIT:C6432"} ! neoplastic syndrome +is_a: MONDO:0021635 {source="Wikipedia:Neurocristopathy"} ! neurocristopathy +property_value: closeMatch http://identifiers.org/meddra/10061299 +property_value: exactMatch http://identifiers.org/mesh/D009377 +property_value: exactMatch http://identifiers.org/snomedct/46724008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027662 +property_value: exactMatch https://omim.org/phenotypicSeries/PS131100 +property_value: exactMatch NCIT:C6432 +property_value: exactMatch Orphanet:276161 +property_value: narrowMatch https://icd.codes/icd10cm/D44.8 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0017181 +name: hypnic headache +def: "Conditions in which the primary symptom is headache and the headache cannot be attributed to any known causes." [MESH:D051270] +subset: ordo_disease {source="Orphanet:276429"} +synonym: "hypnic headache" EXACT [MONDO:ambiguous] +synonym: "hypnic headache (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: GARD:0010796 {source="MONDO:equivalentTo"} +xref: HP:0012459 {source="MONDO:otherHierarchy"} +xref: ICD10CM:G44.8 {source="Orphanet:276429/ntbt", source="Orphanet:276429"} +xref: ICD9:339.81 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D051270 {source="MONDO:equivalentTo"} +xref: Orphanet:276429 {source="MONDO:equivalentTo"} +xref: SCTID:122711000119109 {source="MONDO:equivalentTo"} +is_a: MONDO:0021146 {source="Orphanet:276429"} ! headache disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0020011"} ! rare +property_value: exactMatch http://identifiers.org/mesh/D051270 +property_value: exactMatch http://identifiers.org/snomedct/122711000119109 +property_value: exactMatch Orphanet:276429 +property_value: IAO:0000589 "hypnic headache (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/G44.8 + +[Term] +id: MONDO:0017202 +name: acute endophthalmitis +def: "Acute form of endophthalmitis." [MONDO:patterns/acute] +subset: ordo_clinical_subtype {source="Orphanet:279888"} +synonym: "endophthalmitis, acute" EXACT [MONDO:patterns/acute] +xref: DOID:11752 {source="MONDO:equivalentTo"} +xref: ICD10CM:H44.0 {source="Orphanet:279888", source="Orphanet:279888/ntbt"} +xref: ICD10CM:H44.1 {source="Orphanet:279888", source="Orphanet:279888/ntbt"} +xref: ICD9:360.01 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:11752"} +xref: MedDRA:10000730 {source="Orphanet:279888", source="Orphanet:279888/e"} +xref: Orphanet:279888 {source="MONDO:equivalentTo"} +xref: SCTID:1493002 {source="MONDO:equivalentTo", source="DOID:11752"} +xref: UMLS:C0154773 {source="MONDO:equivalentTo", source="Orphanet:279888", source="Orphanet:279888/e", source="DOID:11752"} +is_a: MONDO:0004863 {source="DOID:11752"} ! purulent endophthalmitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0016047 ! endophthalmitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: closeMatch http://identifiers.org/meddra/10000730 +property_value: exactMatch DOID:11752 +property_value: exactMatch http://identifiers.org/snomedct/1493002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154773 +property_value: exactMatch Orphanet:279888 +property_value: narrowMatch https://icd.codes/icd10cm/H44.1 + +[Term] +id: MONDO:0017203 +name: chronic endophthalmitis +def: "Chronic form of endophthalmitis." [MONDO:patterns/chronic] +subset: ordo_clinical_subtype {source="Orphanet:279891"} +synonym: "endophthalmitis, chronic" EXACT [MONDO:patterns/chronic] +xref: DOID:10697 {source="MONDO:equivalentTo"} +xref: ICD10CM:H44.0 {source="Orphanet:279891/ntbt", source="Orphanet:279891"} +xref: ICD10CM:H44.1 {source="Orphanet:279891/ntbt", source="Orphanet:279891"} +xref: ICD9:360.03 {source="DOID:10697", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10008864 {source="Orphanet:279891/e", source="Orphanet:279891"} +xref: Orphanet:279891 {source="MONDO:equivalentTo"} +xref: SCTID:13978000 {source="DOID:10697", source="MONDO:equivalentTo"} +xref: UMLS:C0154774 {source="DOID:10697", source="Orphanet:279891/e", source="MONDO:equivalentTo", source="Orphanet:279891"} +is_a: MONDO:0004863 {source="DOID:10697"} ! purulent endophthalmitis +intersection_of: MONDO:0016047 ! endophthalmitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: closeMatch http://identifiers.org/meddra/10008864 +property_value: exactMatch DOID:10697 +property_value: exactMatch http://identifiers.org/snomedct/13978000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154774 +property_value: exactMatch Orphanet:279891 +property_value: narrowMatch https://icd.codes/icd10cm/H44.1 + +[Term] +id: MONDO:0017207 +name: primary organ-specific lymphoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:279911"} +xref: NCIT:C7185 {source="MONDO:equivalentTo"} +xref: Orphanet:279911 {source="MONDO:equivalentTo"} +xref: UMLS:C1334465 {source="MONDO:equivalentTo"} +is_a: MONDO:0005062 {source="Orphanet:279911"} ! lymphoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334465 +property_value: exactMatch NCIT:C7185 +property_value: exactMatch Orphanet:279911 + +[Term] +id: MONDO:0017209 +name: infectious posterior uveitis +subset: ordo_disease {source="Orphanet:279919"} +xref: ICD10CM:H20.0 {source="Orphanet:279919/ntbt", source="Orphanet:279919"} +xref: Orphanet:279919 {source="MONDO:equivalentTo"} +is_a: MONDO:0001280 {source="MONDO:Redundant", source="Orphanet:279919"} ! choroiditis +is_a: MONDO:0016047 ! endophthalmitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001776 ! optic choroid +property_value: exactMatch Orphanet:279919 +property_value: narrowMatch https://icd.codes/icd10cm/H20.0 + +[Term] +id: MONDO:0017210 +name: infectious anterior uveitis +def: "An infectious disease involving a pathogenic inflammatory response in the anterior uvea." [MONDO:patterns/specific_inflammatory_disease_by_site] +subset: clingen +subset: ordo_disease {source="Orphanet:279922"} +synonym: "infectious secondary iridocyclitis" EXACT [DOID:9389] +synonym: "secondary infected iridocyclitis" EXACT [DOID:9389] +synonym: "secondary iridocyclitis, infectious" EXACT [DOID:9389, ICD9CM:364.03] +xref: DOID:9389 {source="MONDO:equivalentTo"} +xref: ICD10CM:H20.0 {source="Orphanet:279922", source="Orphanet:279922/ntbt"} +xref: ICD10CM:H20.1 {source="Orphanet:279922", source="Orphanet:279922/ntbt"} +xref: ICD10CM:H20.2 {source="Orphanet:279922", source="Orphanet:279922/ntbt"} +xref: ICD10CM:H20.8 {source="Orphanet:279922", source="Orphanet:279922/ntbt"} +xref: ICD10CM:H20.9 {source="Orphanet:279922", source="Orphanet:279922/ntbt"} +xref: ICD9:364.03 {source="DOID:9389"} +xref: Orphanet:279922 {source="MONDO:equivalentTo"} +xref: SCTID:193487008 {source="MONDO:equivalentTo", source="DOID:9389"} +xref: UMLS:C0154911 {source="MONDO:equivalentTo", source="DOID:9389"} +is_a: MONDO:0004773 {source="DOID:9389"} ! iridocyclitis +is_a: MONDO:0016047 ! endophthalmitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0011892 ! anterior uvea +relationship: disease_has_inflammation_site UBERON:0011892 ! anterior uvea +property_value: exactMatch DOID:9389 +property_value: exactMatch http://identifiers.org/snomedct/193487008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154911 +property_value: exactMatch Orphanet:279922 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: narrowMatch https://icd.codes/icd10cm/H20.0 +property_value: narrowMatch https://icd.codes/icd10cm/H20.1 +property_value: narrowMatch https://icd.codes/icd10cm/H20.2 +property_value: narrowMatch https://icd.codes/icd10cm/H20.8 +property_value: narrowMatch https://icd.codes/icd10cm/H20.9 + +[Term] +id: MONDO:0017256 +name: idiopathic anterior uveitis +subset: ordo_disease {source="Orphanet:280914"} +xref: ICD10CM:H20.0 {source="Orphanet:280914/ntbt", source="Orphanet:280914"} +xref: ICD10CM:H20.1 {source="Orphanet:280914/ntbt", source="Orphanet:280914"} +xref: ICD10CM:H20.2 {source="Orphanet:280914/ntbt", source="Orphanet:280914"} +xref: ICD10CM:H20.8 {source="Orphanet:280914/ntbt", source="Orphanet:280914"} +xref: ICD10CM:H20.9 {source="Orphanet:280914/ntbt", source="Orphanet:280914"} +xref: Orphanet:280914 {source="MONDO:equivalentTo"} +xref: SCTID:231947004 {source="MONDO:equivalentTo"} +xref: UMLS:C0339315 {source="Orphanet:280914", source="MONDO:equivalentTo", source="Orphanet:280914/e"} +is_a: MONDO:0006651 {source="Orphanet:280914"} ! anterior uveitis +is_a: MONDO:0700007 ! idiopathic disease +intersection_of: MONDO:0006651 ! anterior uveitis +intersection_of: has_modifier MONDO:0700005 ! idiopathic +property_value: exactMatch http://identifiers.org/snomedct/231947004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339315 +property_value: exactMatch Orphanet:280914 +property_value: narrowMatch https://icd.codes/icd10cm/H20.0 +property_value: narrowMatch https://icd.codes/icd10cm/H20.1 +property_value: narrowMatch https://icd.codes/icd10cm/H20.2 +property_value: narrowMatch https://icd.codes/icd10cm/H20.8 +property_value: narrowMatch https://icd.codes/icd10cm/H20.9 + +[Term] +id: MONDO:0017276 +name: frontotemporal dementia +def: "Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy." [Orphanet:282] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:282"} +synonym: "frontotemporal lobar degeneration" EXACT [DOID:9255] +synonym: "frontotemporal lobe dementia (FLDEM)" RELATED [GARD:0008436] +synonym: "FTD" EXACT ABBREVIATION [Orphanet:282] +synonym: "MSTD" RELATED ABBREVIATION [GARD:0008436] +synonym: "multiple system tauopathy with presenile dementia" EXACT [DOID:9255] +synonym: "pallidopontonigral degeneration" EXACT [DOID:9255] +synonym: "Wilhemsen-Lynch disease" EXACT [DOID:9255] +xref: DOID:9255 {source="MONDO:equivalentTo"} +xref: GARD:0008436 {source="MONDO:equivalentTo"} +xref: ICD10CM:G31.0 {source="Orphanet:282", source="Orphanet:282/attributed", source="Orphanet:282/ntbt"} +xref: MedDRA:10068968 {source="Orphanet:282", source="Orphanet:282/e"} +xref: MESH:D057180 {source="MONDO:equivalentTo", source="Orphanet:282", source="Orphanet:282/e"} +xref: NCIT:C84719 {source="MONDO:equivalentTo"} +xref: OMIM:172700 {source="Orphanet:282", source="Orphanet:282/btnt"} +xref: OMIM:600795 {source="Orphanet:282", source="Orphanet:282/btnt", source="DOID:9255"} +xref: OMIM:607485 {source="Orphanet:282", source="Orphanet:282/btnt"} +xref: Orphanet:282 {source="MONDO:equivalentTo", source="DOID:9255"} +xref: UMLS:C0338451 {source="MONDO:equivalentTo", source="NCIT:C84719", source="Orphanet:282", source="Orphanet:282/e"} +xref: UMLS:C0520716 {source="MONDO:equivalentTo", source="DOID:9255"} +is_a: MONDO:0015547 {source="MONDO:Redundant", source="Orphanet:282", source="Orphanet:282/inferred"} ! genetic dementia +is_a: MONDO:0024237 {source="MONDO:Redundant", source="Orphanet:282", source="Orphanet:282/inferred"} ! inherited neurodegenerative disorder +relationship: disease_has_feature HP:0002145 ! Frontotemporal dementia +property_value: closeMatch http://identifiers.org/meddra/10068968 +property_value: exactMatch DOID:9255 +property_value: exactMatch http://identifiers.org/mesh/D057180 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0338451 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0520716 +property_value: exactMatch NCIT:C84719 +property_value: exactMatch Orphanet:282 +property_value: excluded_subClassOf MONDO:0003996 {source="DOID:9255"} +property_value: narrowMatch https://icd.codes/icd10cm/G31.0 + +[Term] +id: MONDO:0017278 +name: autoimmune polyendocrinopathy +def: "A group of diverse conditions that are characterized by spontaneous, multi-organ autoimmunity, which target both endocrine (adrenal, gonad, pancreatic islet cells, parathyroid, pituitary, thyroid) and non-endocrine (gastrointestinal, integumentary, lymphatic) tissues." [NCIT:C129726] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:282196"} +synonym: "APS" EXACT ABBREVIATION [Orphanet:282196] +synonym: "autoimmune polyendocrine syndrome" EXACT [DOID:14040] +synonym: "autoimmune polyendocrine syndrome; polyglandular autoimmune syndrome" EXACT [NCIT:C129726] +synonym: "autoimmune polyendocrinopathy" EXACT [DOID:14040, NCIT:C84576] +synonym: "autoimmune polyendocrinopathy syndrome" EXACT [MONDO:0001865, NCIT:C84576] +synonym: "autoimmune polyglandular failure" EXACT [DOID:14040] +synonym: "autoimmune polyglandular syndrome" EXACT [Orphanet:282196] +synonym: "autoimmune polyglandular syndrome(s)" EXACT [NCIT:C129726] +synonym: "Lloyd's syndrome" EXACT [DOID:14040] +xref: DOID:14040 {source="MONDO:equivalentTo"} +xref: ICD10CM:E31.0 {source="Orphanet:282196/ntbt", source="DOID:14040", source="Orphanet:282196", source="MONDO:equivalentTo"} +xref: ICD9:258.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C129726 {source="MONDO:equivalentTo"} +xref: NCIT:C84576 {source="DOID:14040", source="MONDO:equivalentTo"} +xref: Orphanet:282196 {source="MONDO:equivalentTo"} +xref: SCTID:41864002 {source="DOID:14040", source="MONDO:equivalentTo"} +xref: UMLS:C0085409 {source="DOID:14040", source="Orphanet:282196", source="MONDO:equivalentTo", source="Orphanet:282196/e", source="NCIT:C84576"} +xref: UMLS:C4316913 {source="MONDO:equivalentTo"} +is_a: MONDO:0000569 {source="DOID:14040", source="MONDO:Redundant"} ! autoimmune disorder of endocrine system +is_a: MONDO:0002254 {source="NCIT:C129726"} ! syndromic disease +is_a: MONDO:0015126 {source="MONDO:Redundant", source="Orphanet:282196"} ! polyendocrinopathy +intersection_of: MONDO:0015126 ! polyendocrinopathy +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:14040 +property_value: exactMatch http://identifiers.org/snomedct/41864002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085409 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4316913 +property_value: exactMatch https://icd.codes/icd10cm/E31.0 +property_value: exactMatch NCIT:C129726 +property_value: exactMatch NCIT:C84576 +property_value: exactMatch Orphanet:282196 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0017287 +name: IgG4-related disease +def: "A recently described mass-forming lesion that occurs in the pancreas, submandibular glands, lacrimal glands, lymph nodes, and hepatobiliary tract. It is characterized by the presence of marked tissue sclerosis and infiltration by numerous plasma cells. The plasma cells show immunohistochemical staining for IgG4 and the serum IgG4 levels are often increased." [NCIT:C95992] +subset: disease_grouping +subset: ordo_disease +subset: ordo_group_of_disorders {source="Orphanet:284264"} +synonym: "hyper-IgG4 disease" RELATED [GARD:0012521] +synonym: "IgG4-associated disease" RELATED [GARD:0012521] +synonym: "IgG4-positive multiorgan lymphoproliferative syndrome" RELATED [GARD:0012521] +synonym: "IgG4-RD" EXACT ABBREVIATION [Orphanet:596448] +synonym: "IgG4-related autoimmune disease" RELATED [GARD:0012521] +synonym: "IgG4-related sclerosing disease" EXACT [Orphanet:284264] +synonym: "IgG4-related systemic disease" EXACT [Orphanet:284264] +synonym: "IgG4-related systemic sclerosing disease" RELATED [GARD:0012521] +synonym: "IgG4-syndrome" RELATED [GARD:0012521] +synonym: "Immunoglobulin G4-related sclerosing disease" EXACT [Orphanet:284264] +synonym: "multifocal fibrosclerosis" RELATED [GARD:0012521] +synonym: "multifocal idiopathic fibrosclerosis" RELATED [GARD:0012521] +synonym: "systemic IgG4-related plasmacytic syndrome" RELATED [GARD:0012521] +synonym: "systemic IgG4-related sclerosing syndrome" RELATED [GARD:0012521] +xref: DOID:0080356 {source="MONDO:equivalentTo"} +xref: GARD:0012521 {source="DOID:0080356", source="MONDO:equivalentTo"} +xref: MedDRA:10071569 {source="Orphanet:284264", source="Orphanet:284264/e"} +xref: NCIT:C95992 {source="MONDO:equivalentTo"} +xref: Orphanet:284264 {source="DOID:0080356", source="MONDO:equivalentTo"} +xref: Orphanet:596448 {source="MONDO:equivalentTo"} +xref: UMLS:C3203653 {source="Orphanet:284264", source="MONDO:equivalentTo", source="Orphanet:284264/e"} +is_a: MONDO:0007179 {source="DOID:0080356"} ! autoimmune disease +property_value: closeMatch http://identifiers.org/meddra/10071569 +property_value: exactMatch DOID:0080356 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3203653 +property_value: exactMatch NCIT:C95992 +property_value: exactMatch Orphanet:284264 +property_value: exactMatch Orphanet:596448 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3539 xsd:string + +[Term] +id: MONDO:0017306 +name: disorder of phenylalanine metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:284814"} +xref: ICD10CM:E70.0 {source="Orphanet:284814/specific", source="Orphanet:284814/btnt", source="Orphanet:284814"} +xref: ICD10CM:E70.1 {source="Orphanet:284814/specific", source="Orphanet:284814/btnt", source="Orphanet:284814"} +xref: ICD9:270.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:284814 {source="MONDO:equivalentTo"} +xref: SCTID:12957008 {source="MONDO:equivalentTo"} +xref: UMLS:C0268461 {source="Orphanet:284814/e", source="MONDO:equivalentTo", source="Orphanet:284814"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +is_a: MONDO:0019235 {source="Orphanet:284814"} ! inborn disorder of phenylalanin or tyrosine metabolism +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_has_basis_in_disruption_of GO:0006558 ! L-phenylalanine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006558 ! L-phenylalanine metabolic process +property_value: broadMatch https://icd.codes/icd10cm/E70.0 +property_value: broadMatch https://icd.codes/icd10cm/E70.1 +property_value: exactMatch http://identifiers.org/snomedct/12957008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268461 +property_value: exactMatch Orphanet:284814 + +[Term] +id: MONDO:0017307 +name: disorder of tyrosine metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:284818"} +xref: ICD9:270.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:284818 {source="MONDO:equivalentTo"} +xref: SCTID:37200009 {source="MONDO:equivalentTo"} +xref: UMLS:CN202881 {source="MONDO:equivalentTo"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +is_a: MONDO:0019235 {source="Orphanet:284818"} ! inborn disorder of phenylalanin or tyrosine metabolism +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_has_basis_in_disruption_of GO:0006570 ! tyrosine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006570 ! tyrosine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/37200009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202881 +property_value: exactMatch Orphanet:284818 + +[Term] +id: MONDO:0017341 +name: virus associated tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289635"} +xref: Orphanet:289635 {source="MONDO:equivalentTo"} +xref: UMLS:CN203003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="Orphanet:289635"} ! neoplasm +is_a: MONDO:0021674 ! post-viral disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_feature MONDO:0005108 ! viral infectious disease +relationship: has_modifier MONDO:0021136 {source="MONDO:0020031"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203003 +property_value: exactMatch Orphanet:289635 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm_by_origin.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/254 xsd:anyURI + +[Term] +id: MONDO:0017342 +name: Epstein-Barr virus-related tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289638"} +synonym: "EBV-related tumor" EXACT [Orphanet:289638] +xref: Orphanet:289638 {source="MONDO:equivalentTo"} +xref: UMLS:CN203004 {source="MONDO:equivalentTo"} +is_a: MONDO:0017341 {source="Orphanet:289638"} ! virus associated tumor +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203004 +property_value: exactMatch Orphanet:289638 + +[Term] +id: MONDO:0017343 +name: Epstein-Barr virus-associated malignant lymphoproliferative disorder +comment: the classification of diseases such as HL and BL under this class is not consistent with MONDO design patterns, since not all instances of these diseases are caused by EBV +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289644"} +synonym: "EBV-associated lymphoproliferative disorder" EXACT [Orphanet:289644] +xref: MedDRA:10068349 {source="Orphanet:289644", source="Orphanet:289644/e"} +xref: Orphanet:289644 {source="MONDO:equivalentTo"} +xref: UMLS:C2363744 {source="Orphanet:289644", source="MONDO:equivalentTo", source="Orphanet:289644/e"} +is_a: MONDO:0017342 {source="Orphanet:289644"} ! Epstein-Barr virus-related tumor +property_value: closeMatch http://identifiers.org/meddra/10068349 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2363744 +property_value: exactMatch Orphanet:289644 + +[Term] +id: MONDO:0017344 +name: Epstein-Barr virus-associated carcinoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289651"} +synonym: "EBV-associated carcinoma" EXACT [Orphanet:289651] +xref: Orphanet:289651 {source="MONDO:equivalentTo"} +is_a: MONDO:0017342 {source="Orphanet:289651"} ! Epstein-Barr virus-related tumor +property_value: exactMatch Orphanet:289651 + +[Term] +id: MONDO:0017350 +name: inborn disorder of tryptophan metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of tryptophan metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289829"} +synonym: "disorder of tryptophan metabolism" RELATED [Orphanet:289829] +synonym: "inborn error of tryptophan metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn tryptophan metabolic process disorder" EXACT [] +synonym: "rare inborn error of tryptophan metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E70.8 {source="Orphanet:289829/ntbt", source="Orphanet:289829/inclusion", source="Orphanet:289829"} +xref: ICD9:270.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:289829 {source="MONDO:equivalentTo"} +xref: SCTID:5181007 {source="MONDO:equivalentTo"} +xref: UMLS:CN203012 {source="MONDO:equivalentTo"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006568 ! tryptophan metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006568 ! tryptophan metabolic process +property_value: exactMatch http://identifiers.org/snomedct/5181007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203012 +property_value: exactMatch Orphanet:289829 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E70.8 + +[Term] +id: MONDO:0017352 +name: disorder of glutamine metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289841"} +xref: ICD10CM:E72.8 {source="Orphanet:289841/ntbt", source="Orphanet:289841", source="Orphanet:289841/index"} +xref: ICD9:270.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:289841 {source="MONDO:equivalentTo"} +xref: SCTID:190724004 {source="MONDO:equivalentTo"} +xref: UMLS:C0342669 {source="Orphanet:289841", source="MONDO:equivalentTo", source="Orphanet:289841/e"} +is_a: MONDO:0019189 {source="MONDO:Redundant", source="Orphanet:289841"} ! inborn disorder of amino acid and other organic acid metabolism +intersection_of: MONDO:0019189 ! inborn disorder of amino acid and other organic acid metabolism +intersection_of: disease_disrupts GO:0006541 ! glutamine metabolic process +relationship: disease_disrupts GO:0006541 ! glutamine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/190724004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342669 +property_value: exactMatch Orphanet:289841 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E72.8 + +[Term] +id: MONDO:0017355 +name: inborn disorder of proline metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of proline metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289866"} +synonym: "disorder of proline metabolism" EXACT [Orphanet:289866] +synonym: "inborn error of proline metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn proline metabolic process disorder" EXACT [] +synonym: "rare inborn error of proline metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E72.8 {source="Orphanet:289866", source="Orphanet:289866/attributed", source="Orphanet:289866/ntbt"} +xref: Orphanet:289866 {source="MONDO:equivalentTo"} +xref: UMLS:CN227118 {source="MONDO:equivalentTo"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +is_a: MONDO:0019230 {source="Orphanet:289866"} ! inborn disorder of ornithine or proline metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006560 ! proline metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006560 ! proline metabolic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227118 +property_value: exactMatch Orphanet:289866 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E72.8 + +[Term] +id: MONDO:0017356 +name: inborn disorder of ornithine metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of ornithine metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:289869"} +synonym: "disorder of ornithine metabolism" EXACT [Orphanet:289869] +synonym: "inborn error of ornithine metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn ornithine metabolic process disorder" EXACT [] +synonym: "rare inborn error of ornithine metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: Orphanet:289869 {source="MONDO:equivalentTo"} +xref: SCTID:237928008 {source="MONDO:equivalentTo"} +xref: UMLS:C0342690 {source="Orphanet:289869/e", source="MONDO:equivalentTo", source="Orphanet:289869"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +is_a: MONDO:0019230 {source="Orphanet:289869"} ! inborn disorder of ornithine or proline metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006591 ! ornithine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006591 ! ornithine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/237928008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342690 +property_value: exactMatch Orphanet:289869 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0017366 +name: hereditary pheochromocytoma-paraganglioma +def: "Hereditary paraganglioma-pheochromocytomas (PGL/PCC) are rare neuroendocrine tumors represented by paragangliomas (occurring in any paraganglia from the skull base to the pelvic floor) and pheochromocytomas (adrenal medullary paragangliomas)." [Orphanet:29072] +subset: clingen +subset: gard_rare {source="GARD:0011984"} +subset: ordo_disease {source="Orphanet:29072"} +synonym: "familial pheochromocytoma-paraganglioma" EXACT [Orphanet:29072] +synonym: "hereditary paraganglioma-pheochromocytoma" RELATED [GARD:0011984] +synonym: "hereditary pheochromocytoma-paraganglioma" EXACT [] +synonym: "SDHx-related paraganglioma-pheochromocytoma" RELATED [GARD:0011984] +xref: GARD:0011984 {source="MONDO:equivalentTo"} +xref: ICD10CM:C74.1 {source="Orphanet:29072", source="Orphanet:29072/attributed", source="Orphanet:29072/ntbt"} +xref: ICD10CM:C75.5 {source="Orphanet:29072", source="Orphanet:29072/attributed", source="Orphanet:29072/ntbt"} +xref: ICD10CM:D35.0 {source="Orphanet:29072", source="Orphanet:29072/attributed", source="Orphanet:29072/ntbt"} +xref: ICD10CM:D35.6 {source="Orphanet:29072", source="Orphanet:29072/attributed", source="Orphanet:29072/ntbt"} +xref: OMIM:115310 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: OMIM:168000 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: OMIM:171300 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: OMIM:601650 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: OMIM:605373 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: OMIM:614165 {source="Orphanet:29072", source="Orphanet:29072/btnt"} +xref: Orphanet:29072 {source="MONDO:equivalentTo"} +xref: UMLS:C1708353 {source="MONDO:equivalentTo"} +is_a: MONDO:0005495 {source="Orphanet:29072"} ! adrenal gland disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0015971"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1708353 +property_value: exactMatch Orphanet:29072 +property_value: narrowMatch https://icd.codes/icd10cm/C74.1 +property_value: narrowMatch https://icd.codes/icd10cm/C75.5 +property_value: narrowMatch https://icd.codes/icd10cm/D35.0 +property_value: narrowMatch https://icd.codes/icd10cm/D35.6 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/11984/hereditary-paraganglioma-pheochromocytoma xsd:anyURI {source="GARD:0011984"} + +[Term] +id: MONDO:0017582 +name: pituitary adenocarcinoma +def: "A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly." [NCIT:C4536] +subset: ordo_disease {source="Orphanet:300385"} +synonym: "cancer of pituitary" BROAD [NCIT:C4536] +synonym: "cancer of pituitary gland" BROAD [NCIT:C4536] +synonym: "cancer of the pituitary" BROAD [NCIT:C4536] +synonym: "cancer of the pituitary gland" BROAD [NCIT:C4536] +synonym: "carcinoma of pituitary" EXACT [NCIT:C4536] +synonym: "carcinoma of pituitary gland" EXACT [NCIT:C4536] +synonym: "carcinoma of the pituitary" EXACT [NCIT:C4536] +synonym: "carcinoma of the pituitary gland" EXACT [DOID:4916, NCIT:C4536] +synonym: "pituitary adenocarcinoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "pituitary carcinoma" EXACT [MONDO:ambiguous, NCIT:C4536] +synonym: "pituitary gland adenocarcinoma" EXACT [MONDO:patterns/location, NCIT:C4536] +synonym: "pituitary gland cancer" BROAD [NCIT:C4536] +synonym: "pituitary gland carcinoma" EXACT [NCIT:C4536] +synonym: "PTCA" RELATED ABBREVIATION [ONCOTREE:PTCA] +xref: DOID:4916 {source="MONDO:equivalentTo"} +xref: HP:0011763 {source="MONDO:otherHierarchy"} +xref: ICD10CM:C75.1 {source="Orphanet:300385/ntbt", source="Orphanet:300385"} +xref: ICDO:8272/3 {source="NCIT:C4536"} +xref: NCIT:C4536 {source="MONDO:equivalentTo", source="DOID:4916"} +xref: ONCOTREE:PTCA {source="MONDO:equivalentTo"} +xref: Orphanet:300385 {source="MONDO:equivalentTo"} +xref: SCTID:254955001 {source="MONDO:equivalentTo", source="DOID:4916"} +xref: UMLS:C0346300 {source="Orphanet:300385/e", source="MONDO:equivalentTo", source="DOID:4916", source="NCIT:C4536", source="Orphanet:300385"} +is_a: MONDO:0002038 ! head and neck carcinoma +is_a: MONDO:0002109 {source="DOID:4916", source="MONDO:Redundant", source="NCIT:C4536"} ! pituitary cancer +is_a: MONDO:0002415 ! bone carcinoma +is_a: MONDO:0004970 {source="MONDO:Redundant", source="NCIT:C4536"} ! adenocarcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +property_value: exactMatch DOID:4916 +property_value: exactMatch http://identifiers.org/snomedct/254955001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346300 +property_value: exactMatch NCIT:C4536 +property_value: exactMatch Orphanet:300385 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: IAO:0000589 "pituitary adenocarcinoma (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/C75.1 + +[Term] +id: MONDO:0017588 +name: nail tumor +def: "A neoplasm involving a nail." [MONDO:patterns/neoplasm] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:300515"} +synonym: "nail neoplasm" EXACT [] +synonym: "nail neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nail tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of nail" EXACT [MONDO:patterns/neoplasm] +synonym: "rare nail tumor" RELATED [Orphanet:300515] +synonym: "tumor of nail" EXACT [MONDO:patterns/neoplasm] +xref: Orphanet:300515 {source="MONDO:equivalentTo"} +is_a: MONDO:0002884 ! nail disorder +is_a: MONDO:0005070 ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001705 ! nail +property_value: exactMatch Orphanet:300515 +property_value: excluded_subClassOf MONDO:0019300 {source="Orphanet:300515"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0017590 +name: carcinoma of the ampulla of vater +def: "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss." [NCIT:C3908] +subset: ordo_disease {source="Orphanet:300557"} +synonym: "AMPCA" RELATED ABBREVIATION [ONCOTREE:AMPCA] +synonym: "ampulla of Vater cancer" EXACT [NCIT:C3908] +synonym: "ampulla of Vater carcinoma" EXACT [MONDO:0006080, NCIT:C3908] +synonym: "ampullary cancer" EXACT [NCIT:C3908] +synonym: "ampullary carcinoma" EXACT [NCIT:C3908, Orphanet:300557] +synonym: "Ampulloma" EXACT [Orphanet:300557] +synonym: "carcinoma of ampulla of vater" EXACT [DOID:4932] +synonym: "carcinoma of hepatopancreatic ampulla" EXACT [MONDO:patterns/carcinoma] +synonym: "hepatopancreatic ampulla carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4932 {source="MONDO:equivalentTo"} +xref: EFO:1000079 {source="MONDO:equivalentTo"} +xref: ICD10CM:C24.1 {source="Orphanet:300557", source="Orphanet:300557/ntbt"} +xref: MedDRA:10048853 {source="Orphanet:300557", source="Orphanet:300557/e"} +xref: NCIT:C3908 {source="DOID:4932", source="MONDO:equivalentTo", source="EFO:1000079"} +xref: ONCOTREE:AMPCA {source="MONDO:equivalentTo"} +xref: Orphanet:300557 {source="MONDO:equivalentTo"} +xref: SCTID:254609000 {source="DOID:4932", source="MONDO:equivalentTo"} +xref: UMLS:C0262401 {source="DOID:4932", source="MONDO:equivalentTo", source="NCIT:C3908", source="Orphanet:300557", source="Orphanet:300557/e"} +is_a: MONDO:0000919 {source="DOID:4932", source="MONDO:Redundant", source="NCIT:C3908"} ! ampulla of vater cancer +is_a: MONDO:0003090 ! extrahepatic bile duct carcinoma +is_a: MONDO:0021335 {source="MONDO:Redundant"} ! carcinoma of duodenum +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0004913 ! hepatopancreatic ampulla +property_value: closeMatch http://identifiers.org/meddra/10048853 +property_value: exactMatch DOID:4932 +property_value: exactMatch http://identifiers.org/snomedct/254609000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0262401 +property_value: exactMatch NCIT:C3908 +property_value: exactMatch Orphanet:300557 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C24.1 + +[Term] +id: MONDO:0017594 +name: indolent B-cell non-Hodgkin lymphoma +subset: disease_grouping +subset: gard_rare +subset: ordo_group_of_disorders {source="Orphanet:300842"} +synonym: "B cell lymphoma, indolent" RELATED [GARD:0010482] +synonym: "indolent B cell lymphoma" RELATED [GARD:0010482] +synonym: "indolent B-cell NHL" EXACT [Orphanet:300842] +xref: GARD:0010482 {source="MONDO:equivalentTo"} +xref: NCIT:C171299 {source="MONDO:equivalentTo"} +xref: Orphanet:300842 {source="MONDO:equivalentTo"} +is_a: MONDO:0015759 {source="Orphanet:300842"} ! B-cell non-Hodgkin lymphoma +property_value: exactMatch NCIT:C171299 +property_value: exactMatch Orphanet:300842 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/10482/indolent-B-cell-lymphoma xsd:anyURI {source="GARD:0010482"} + +[Term] +id: MONDO:0017604 +name: marginal zone lymphoma +def: "A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood." [NCIT:C4341] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:300912"} +synonym: "lymphoma of marginal zone B cell" EXACT [MONDO:design_pattern] +synonym: "marginal zone B cell lymphoma" EXACT [MONDO:patterns/location] +synonym: "marginal zone B-cell lymphoma" EXACT [MONDO:0006495, NCIT:C4341] +synonym: "marginal zone lymphoma" EXACT [DOID:0050748, NCIT:C4341] +synonym: "MZBCL" EXACT ABBREVIATION [NCIT:C4341] +synonym: "MZL" EXACT ABBREVIATION [NCIT:C4341] +xref: DOID:0050748 {source="MONDO:equivalentTo"} +xref: EFO:1000630 {source="MONDO:equivalentTo"} +xref: GARD:0013237 {source="MONDO:equivalentTo"} +xref: ICDO:9699/3 {source="NCIT:C4341"} +xref: NCIT:C4341 {source="EFO:1000630", source="MONDO:equivalentTo"} +xref: ONCOTREE:MZL {source="MONDO:equivalentTo"} +xref: Orphanet:300912 {source="MONDO:equivalentTo"} +xref: SCTID:447100004 {source="MONDO:equivalentTo"} +xref: UMLS:C1367654 {source="NCIT:C4341", source="MONDO:equivalentTo"} +is_a: MONDO:0004699 ! gastrointestinal lymphoma +is_a: MONDO:0005966 ! spleen cancer +is_a: MONDO:0017594 {source="Orphanet:300912"} ! indolent B-cell non-Hodgkin lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location CL:0000845 ! marginal zone B cell of spleen +relationship: disease_has_location CL:0000845 ! marginal zone B cell of spleen +property_value: exactMatch DOID:0050748 +property_value: exactMatch http://identifiers.org/snomedct/447100004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1367654 +property_value: exactMatch NCIT:C4341 +property_value: exactMatch Orphanet:300912 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0017611 +name: pituitary tumor +def: "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland." [NCIT:C3330] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:304055"} +synonym: "neoplasm of pituitary" EXACT [NCIT:C3330] +synonym: "neoplasm of pituitary gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3330] +synonym: "neoplasm of the pituitary" EXACT [NCIT:C3330] +synonym: "neoplasm of the pituitary gland" EXACT [NCIT:C3330] +synonym: "pituitary gland neoplasm" EXACT [NCIT:C3330] +synonym: "pituitary gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3330] +synonym: "pituitary neoplasm" EXACT [NCIT:C3330] +synonym: "pituitary tumor" EXACT [NCIT:C3330] +synonym: "tumor of pituitary" EXACT [NCIT:C3330] +synonym: "tumor of pituitary gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3330] +synonym: "tumor of the pituitary" EXACT [NCIT:C3330] +synonym: "tumor of the pituitary gland" EXACT [NCIT:C3330] +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3330 {source="MONDO:equivalentTo"} +xref: Orphanet:304055 {source="MONDO:equivalentTo"} +xref: SCTID:127024001 {source="MONDO:equivalentTo"} +xref: UMLS:C0032019 {source="NCIT:C3330", source="MONDO:equivalentTo", source="Orphanet:304055"} +is_a: MONDO:0002082 {source="MONDO:Entailed", source="Orphanet:304055"} ! endocrine gland neoplasm +is_a: MONDO:0002720 {source="MONDO:Entailed", source="NCIT:C3330"} ! sella turcica neoplasm +is_a: MONDO:0003381 {source="MONDO:Redundant", source="NCIT:C3330"} ! pituitary gland disorder +is_a: MONDO:0006799 ! hypothalamic neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +property_value: exactMatch http://identifiers.org/snomedct/127024001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0032019 +property_value: exactMatch NCIT:C3330 +property_value: exactMatch Orphanet:304055 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0017688 +name: disorder of glycolysis +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:308459"} +xref: Orphanet:308459 {source="MONDO:equivalentTo"} +xref: UMLS:CN227176 {source="MONDO:equivalentTo"} +is_a: MONDO:0016789 ! pyruvate metabolism disorder +is_a: MONDO:0019214 {source="MONDO:Redundant", source="Orphanet:308459"} ! inborn carbohydrate metabolic disorder +is_a: MONDO:0019254 ! inborn disorder of purine or pyrimidine metabolism +intersection_of: MONDO:0019214 ! inborn carbohydrate metabolic disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006096 ! glycolytic process +relationship: disease_has_basis_in_disruption_of GO:0006096 ! glycolytic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227176 +property_value: exactMatch Orphanet:308459 + +[Term] +id: MONDO:0017689 +name: disorder of fructose metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:308463"} +xref: Orphanet:308463 {source="MONDO:equivalentTo"} +xref: SCTID:39452003 {source="MONDO:equivalentTo"} +xref: UMLS:C0342744 {source="MONDO:equivalentTo", source="Orphanet:308463", source="Orphanet:308463/e"} +is_a: MONDO:0019214 {source="MONDO:Redundant", source="Orphanet:308463"} ! inborn carbohydrate metabolic disorder +intersection_of: MONDO:0019214 ! inborn carbohydrate metabolic disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006000 ! fructose metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006000 ! fructose metabolic process +property_value: exactMatch http://identifiers.org/snomedct/39452003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342744 +property_value: exactMatch Orphanet:308463 + +[Term] +id: MONDO:0017690 +name: disorder of galactose metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:308467"} +xref: Orphanet:308467 {source="MONDO:equivalentTo"} +xref: SCTID:237963003 {source="MONDO:equivalentTo"} +xref: UMLS:C0342745 {source="Orphanet:308467/e", source="MONDO:equivalentTo", source="Orphanet:308467"} +is_a: MONDO:0019214 {source="MONDO:Redundant", source="Orphanet:308467"} ! inborn carbohydrate metabolic disorder +intersection_of: MONDO:0019214 ! inborn carbohydrate metabolic disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006012 ! galactose metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006012 ! galactose metabolic process +property_value: exactMatch http://identifiers.org/snomedct/237963003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342745 +property_value: exactMatch Orphanet:308467 + +[Term] +id: MONDO:0017704 +name: familial partial epilepsy +def: "An instance of partial epilepsy that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: gard_rare {source="GARD:0002173"} +subset: ordo_group_of_disorders {source="Orphanet:309"} +synonym: "epilepsy, partial, familial" RELATED [GARD:0002173] +synonym: "hereditary partial epilepsy" EXACT [MONDO:patterns/hereditary] +xref: GARD:0002173 {source="MONDO:equivalentTo"} +xref: ICD10CM:G40.1 {source="Orphanet:309", source="Orphanet:309/attributed", source="Orphanet:309/ntbt"} +xref: Orphanet:309 {source="MONDO:equivalentTo"} +xref: UMLS:CN227178 {source="MONDO:equivalentTo"} +is_a: MONDO:0005384 ! partial epilepsy +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0020072 {source="Orphanet:309"} ! childhood-onset epilepsy syndrome +is_a: MONDO:0020073 {source="Orphanet:309"} ! adolescent-onset epilepsy syndrome +intersection_of: MONDO:0005384 ! partial epilepsy +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227178 +property_value: exactMatch Orphanet:309 +property_value: narrowMatch https://icd.codes/icd10cm/G40.1 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/2173/epilepsy-partial-familial xsd:anyURI {source="GARD:0002173"} + +[Term] +id: MONDO:0017706 +name: disorder of carbohydrate absorption and transport +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:309001"} +xref: Orphanet:309001 {source="MONDO:equivalentTo"} +xref: UMLS:CN227180 {source="MONDO:equivalentTo"} +is_a: MONDO:0019214 {source="Orphanet:309001"} ! inborn carbohydrate metabolic disorder +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227180 +property_value: exactMatch Orphanet:309001 + +[Term] +id: MONDO:0017740 +name: disorder of protein N-glycosylation +def: "A disease that has its basis in the disruption of protein N-linked glycosylation." [MONDO:patterns/basis_in_disruption_of_process] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:309347"} +synonym: "disorder of protein N-linked glycosylation" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "protein N-linked glycosylation disease" EXACT [MONDO:design_pattern] +xref: ICD10CM:E77.8 {source="Orphanet:309347/attributed", source="Orphanet:309347/ntbt", source="Orphanet:309347"} +xref: Orphanet:309347 {source="MONDO:equivalentTo"} +xref: UMLS:CN227187 {source="MONDO:equivalentTo"} +is_a: MONDO:0015286 {source="Orphanet:309347"} ! congenital disorder of glycosylation +is_a: MONDO:0045010 ! glycoprotein metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006487 ! protein N-linked glycosylation +relationship: disease_has_basis_in_disruption_of GO:0006487 ! protein N-linked glycosylation +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227187 +property_value: exactMatch Orphanet:309347 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E77.8 + +[Term] +id: MONDO:0017741 +name: disorder of protein O-glycosylation +def: "A disease that has its basis in the disruption of protein O-linked glycosylation." [MONDO:patterns/basis_in_disruption_of_process] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:309447"} +synonym: "disorder of protein O-linked glycosylation" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "protein O-linked glycosylation disease" EXACT [MONDO:design_pattern] +xref: ICD10CM:E77.8 {source="Orphanet:309447/attributed", source="Orphanet:309447/ntbt", source="Orphanet:309447"} +xref: Orphanet:309447 {source="MONDO:equivalentTo"} +xref: UMLS:CN227188 {source="MONDO:equivalentTo"} +is_a: MONDO:0015286 {source="Orphanet:309447"} ! congenital disorder of glycosylation +is_a: MONDO:0045010 ! glycoprotein metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006493 ! protein O-linked glycosylation +relationship: disease_has_basis_in_disruption_of GO:0006493 ! protein O-linked glycosylation +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227188 +property_value: exactMatch Orphanet:309447 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E77.8 + +[Term] +id: MONDO:0017814 +name: primary bone lymphoma +def: "A rare non-Hodgkin lymphoma or even more rarely, a Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement. The femur, spine, and pelvic bones are the most commonly affected sites. The majority of patients present with bone pain in the affected area. A single bone or multiple skeletal sites may be involved. The prognosis is related to the cell type and the stage of the disease." [NCIT:C6620] +subset: ordo_disease {source="Orphanet:314684"} +synonym: "bone lymphoma" RELATED [DOID:6759] +synonym: "bone tissue lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lymphoma of bone" EXACT [DOID:6759] +synonym: "lymphoma of bone tissue" EXACT [MONDO:design_pattern] +synonym: "lymphoma of the bone" EXACT [DOID:6759] +synonym: "primary lymphoma of bone" EXACT [NCIT:C6620] +synonym: "primary lymphoma of the bone" EXACT [NCIT:C6620] +xref: DOID:6759 {source="MONDO:equivalentTo"} +xref: NCIT:C6620 {source="MONDO:equivalentTo", source="DOID:6759"} +xref: Orphanet:314684 {source="MONDO:equivalentTo"} +xref: SCTID:766935007 {source="MONDO:equivalentTo"} +xref: UMLS:C1332582 {source="MONDO:equivalentTo", source="NCIT:C6620", source="DOID:6759"} +is_a: MONDO:0002129 {source="NCIT:C6620"} ! bone cancer +is_a: MONDO:0017207 {source="Orphanet:314684"} ! primary organ-specific lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +property_value: exactMatch DOID:6759 +property_value: exactMatch http://identifiers.org/snomedct/766935007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332582 +property_value: exactMatch NCIT:C6620 +property_value: exactMatch Orphanet:314684 +property_value: excluded_subClassOf MONDO:0002129 {source="DOID:6759"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0017853 +name: hypersensitivity pneumonitis +def: "Hypersensitivity pneumonitis (HP) is a pulmonary disease with symptoms of dyspnea and cough resulting from the inhalation of an antigen to which the subject has been previously sensitized." [Orphanet:31740] +subset: disease_grouping +subset: gard_rare +subset: ordo_group_of_disorders {source="Orphanet:31740"} +synonym: "allergic form of pneumonitis" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic interstitial pneumonitis" RELATED [GARD:0000012] +synonym: "allergic pneumonitis" EXACT [GARD:0000012, NCIT:C34369] +synonym: "alveolitis" EXACT [DOID:841] +synonym: "alveolitis, extrinsic allergic" RELATED [GARD:0000012] +synonym: "exogen allergic alveolitis" EXACT [https://orcid.org/0000-0003-0113-912Xf] +synonym: "extrinsic allergic alveolitis" EXACT [NCIT:C34369, Orphanet:31740] +synonym: "extrinsic allergic pneumonia hypersensitivity pneumonitis" RELATED [GARD:0000012] +synonym: "HP" EXACT ABBREVIATION [Orphanet:31740] +synonym: "hypersensitivity pneumonitis" EXACT [DOID:841, GARD:0000012, NCIT:C34369] +xref: DOID:841 {source="MONDO:equivalentTo"} +xref: GARD:0000012 {source="MONDO:equivalentTo"} +xref: ICD10CM:J67.0 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.1 {source="Orphanet:31740", source="MONDO:relatedTo", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.2 {source="Orphanet:31740", source="Orphanet:31740/btnt", source="MONDO:directSiblingOf"} +xref: ICD10CM:J67.3 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.4 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.5 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.6 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.7 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.8 {source="Orphanet:31740", source="Orphanet:31740/btnt"} +xref: ICD10CM:J67.9 {source="Orphanet:31740", source="DOID:841", source="Orphanet:31740/btnt"} +xref: ICD9:495 {source="DOID:841"} +xref: ICD9:495.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:495.9 {source="DOID:841", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10001890 {source="Orphanet:31740", source="Orphanet:31740/e"} +xref: MESH:D000542 {source="Orphanet:31740", source="DOID:841", source="MONDO:equivalentTo", source="Orphanet:31740/e"} +xref: NCIT:C34369 {source="DOID:841", source="MONDO:equivalentTo"} +xref: Orphanet:31740 {source="GARD:0000012", source="MONDO:equivalentTo"} +xref: SCTID:37471005 {source="DOID:841", source="MONDO:equivalentTo"} +is_a: MONDO:0000771 {source="Orphanet:31740"} ! allergic respiratory disease +is_a: MONDO:0017040 {source="Orphanet:31740"} ! exposure-related interstitial lung disease +is_a: MONDO:0043905 ! pneumonitis +intersection_of: MONDO:0043905 ! pneumonitis +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +relationship: disease_has_feature HP:0001824 ! Weight loss +relationship: disease_has_feature HP:0006530 ! Abnormal pulmonary interstitial morphology +relationship: has_modifier MONDO:0021136 {source="MONDO:0020028"} ! rare +property_value: broadMatch https://icd.codes/icd10cm/J67.0 +property_value: broadMatch https://icd.codes/icd10cm/J67.3 +property_value: broadMatch https://icd.codes/icd10cm/J67.4 +property_value: broadMatch https://icd.codes/icd10cm/J67.5 +property_value: broadMatch https://icd.codes/icd10cm/J67.6 +property_value: broadMatch https://icd.codes/icd10cm/J67.7 +property_value: broadMatch https://icd.codes/icd10cm/J67.8 +property_value: broadMatch https://icd.codes/icd10cm/J67.9 +property_value: closeMatch http://identifiers.org/meddra/10001890 +property_value: exactMatch DOID:841 +property_value: exactMatch http://identifiers.org/mesh/D000542 +property_value: exactMatch http://identifiers.org/snomedct/37471005 +property_value: exactMatch NCIT:C34369 +property_value: exactMatch Orphanet:31740 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4323 + +[Term] +id: MONDO:0017907 +name: primary lymphoma of the conjunctiva +def: "Primary lymphoma of the conjunctiva is an extremely rare clonal lymphoid proliferation of the ocular surface, with an indolent course. Clinically it presents with treatment-resistant conjunctivitis, ptosis, excessive tear production or as a painless, salmon-pink, ''fleshy'' patch, with a smooth or multinodular surface, on the bulbar conjunctiva. Histologically it is usually B-cell Non-Hodgkin lymphoma (most often extranodal marginal zone B-cell lymphoma, followed by follicular and diffuse large B-cell lymphoma), with conjunctival T-cell Non-Hodgkin lymphoma being very rare." [Orphanet:319667] +subset: ordo_disease {source="Orphanet:319667"} +synonym: "conjunctiva lymphoma" EXACT [MONDO:patterns/location] +synonym: "conjunctiva primary organ-specific lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lymphoma of conjunctiva" EXACT [] +synonym: "primary lymphoid conjunctival tumor" EXACT [Orphanet:319667] +synonym: "primary organ-specific lymphoma of conjunctiva" EXACT [MONDO:design_pattern] +xref: Orphanet:319667 {source="MONDO:equivalentTo"} +xref: SCTID:763477007 {source="MONDO:equivalentTo"} +xref: UMLS:CN203974 {source="MONDO:equivalentTo"} +is_a: MONDO:0003454 ! conjunctival cancer +is_a: MONDO:0004034 ! eye lymphoma +is_a: MONDO:0017207 {source="MONDO:Redundant", source="Orphanet:319667"} ! primary organ-specific lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +property_value: exactMatch http://identifiers.org/snomedct/763477007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN203974 +property_value: exactMatch Orphanet:319667 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0018017 +name: goblet cell carcinoma +def: "An aggressive type of endocrine tumor of the appendix presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis." [https://orcid.org/0000-0001-5208-3432, Orphanet:329984] +subset: ordo_clinical_subtype {source="Orphanet:329984"} +synonym: "appendix adenocarcinoid tumor" EXACT [NCIT:C3689] +synonym: "appendix goblet cell carcinoid" EXACT [MONDO:0006089] +synonym: "appendix goblet cell carcinoid tumor" EXACT [NCIT:C3689] +synonym: "appendix mixed carcinoid-adenocarcinoma" EXACT [NCIT:C3689] +synonym: "carcinoma of goblet cell" EXACT [MONDO:patterns/carcinoma] +synonym: "GCC" EXACT ABBREVIATION [Orphanet:329984] +synonym: "goblet cell adenocarcinoid" EXACT [Orphanet:329984] +synonym: "goblet cell carcinoid" EXACT [Orphanet:329984] +synonym: "goblet cell carcinoid of appendix" EXACT [] +synonym: "goblet cell carcinoid of the appendix" EXACT [] +synonym: "goblet cell carcinoid tumor" EXACT [NCIT:C3689] +synonym: "goblet cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "goblet cell tumor" EXACT [Orphanet:329984] +synonym: "mucinous carcinoid" RELATED [GARD:0010414] +synonym: "mucinous carcinoid tumor" EXACT [NCIT:C3689] +xref: EFO:1000090 {source="MONDO:equivalentTo"} +xref: GARD:0010414 {source="MONDO:equivalentTo"} +xref: ICD10CM:C18.1 {source="Orphanet:329984/ntbt", source="Orphanet:329984"} +xref: ICDO:8243/3 {source="NCIT:C3689"} +xref: NCIT:C3689 {source="MONDO:equivalentTo", source="EFO:1000090", source="MONDO:exact-label-match"} +xref: ONCOTREE:GCCAP {source="MONDO:equivalentTo"} +xref: Orphanet:329984 {source="MONDO:equivalentTo"} +is_a: MONDO:0002120 ! neuroendocrine carcinoma +is_a: MONDO:0003196 ! appendix carcinoma +is_a: MONDO:0015066 {source="Orphanet:329984"} ! neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade +is_a: MONDO:0021659 {source="NCIT:C3689"} ! combined carcinoid and adenocarcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0000160 ! goblet cell +relationship: disease_has_location CL:0000160 ! goblet cell +property_value: exactMatch NCIT:C3689 +property_value: exactMatch Orphanet:329984 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C18.1 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4635 + +[Term] +id: MONDO:0018055 +name: pediatric hepatocellular carcinoma +def: "Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age." [Orphanet:33402] +subset: ordo_clinical_subtype {source="Orphanet:33402"} +synonym: "childhood carcinoma of liver cell" RELATED [GARD:0009331] +synonym: "childhood carcinoma of the liver cell" EXACT [NCIT:C7955] +synonym: "childhood hepatocellular carcinoma" EXACT [DOID:0070322, GARD:0009331] +synonym: "childhood hepatoma" RELATED [GARD:0009331] +synonym: "childhood liver cell carcinoma" RELATED [GARD:0009331] +synonym: "childhood-onset HCC" EXACT [Orphanet:33402] +synonym: "childhood-onset hepatocellular carcinoma" EXACT [Orphanet:33402] +synonym: "hepatocellular cancer" BROAD [NCIT:C7955] +synonym: "pediatric carcinoma of liver cell" RELATED [GARD:0009331] +synonym: "Pediatric carcinoma of the liver cell" EXACT [NCIT:C7955] +synonym: "pediatric HCC" EXACT [Orphanet:33402] +synonym: "pediatric hepatoma" RELATED [GARD:0009331] +synonym: "pediatric liver cell carcinoma" RELATED [GARD:0009331] +xref: DOID:0070322 {source="MONDO:equivalentTo"} +xref: GARD:0009331 {source="DOID:0070322", source="MONDO:equivalentTo"} +xref: ICD10CM:C22.0 {source="Orphanet:33402/ntbt", source="Orphanet:33402"} +xref: NCIT:C7955 {source="DOID:0070322", source="MONDO:equivalentTo"} +xref: Orphanet:33402 {source="DOID:0070322", source="MONDO:equivalentTo"} +xref: UMLS:CN204349 {source="MONDO:equivalentTo"} +is_a: MONDO:0006517 ! childhood malignant neoplasm +is_a: MONDO:0007256 {source="DOID:0070322", source="NCIT:C7955", source="Orphanet:33402"} ! hepatocellular carcinoma +intersection_of: MONDO:0007256 ! hepatocellular carcinoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch DOID:0070322 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204349 +property_value: exactMatch NCIT:C7955 +property_value: exactMatch Orphanet:33402 +property_value: narrowMatch https://icd.codes/icd10cm/C22.0 + +[Term] +id: MONDO:0018075 +name: neural tube defect +def: "A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida." [NCIT:C84923] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:3388"} +synonym: "NTD" EXACT ABBREVIATION [NCIT:C84923] +synonym: "spinal dysraphism" EXACT [NCIT:C84923] +xref: DOID:0080074 {source="MONDO:equivalentTo"} +xref: ICD9:742.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009436 {source="MONDO:equivalentTo"} +xref: NCIT:C84923 {source="MONDO:equivalentTo"} +xref: Orphanet:3388 {source="MONDO:equivalentTo"} +xref: SCTID:253098009 {source="MONDO:equivalentTo"} +is_a: MONDO:0020022 {source="MESH:D009436", source="Orphanet:3388/inferred", source="https://github.com/monarch-initiative/mondo-build/issues/58"} ! central nervous system malformation +property_value: exactMatch DOID:0080074 +property_value: exactMatch http://identifiers.org/mesh/D009436 +property_value: exactMatch http://identifiers.org/snomedct/253098009 +property_value: exactMatch NCIT:C84923 +property_value: exactMatch Orphanet:3388 +property_value: excluded_subClassOf MONDO:0015219 {source="Orphanet:3388"} +property_value: excluded_subClassOf MONDO:0019117 {source="MONDO:Redundant", source="Orphanet:3388", source="Orphanet:3388/inferred"} + +[Term] +id: MONDO:0018079 +name: thymic epithelial neoplasm +def: "An epithelial neoplasm that affects the thymus gland. This category includes thymomas and carcinomas." [NCIT:C6450] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:3398"} +synonym: "epithelial neoplasm of the Thymus" EXACT [NCIT:C6450] +synonym: "epithelial neoplasm of Thymus" EXACT [NCIT:C6450] +synonym: "epithelial tumor of the Thymus" EXACT [NCIT:C6450] +synonym: "epithelial tumor of Thymus" EXACT [NCIT:C6450] +synonym: "TEN" EXACT ABBREVIATION [Orphanet:3398] +synonym: "Tet" RELATED [ONCOTREE:TET] +synonym: "thymic epithelial tumor" EXACT [NCIT:C6450, Orphanet:3398] +synonym: "thymic epithelium neoplasm" EXACT [NCIT:C6450] +synonym: "thymoma, adult" RELATED [GARD:0005201] +synonym: "Thymus epithelial neoplasm" EXACT [NCIT:C6450] +synonym: "thymus epithelial neoplasm" EXACT [MONDO:patterns/location] +synonym: "Thymus epithelial tumor" EXACT [NCIT:C6450] +xref: GARD:0005201 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD10CM:C37 {source="Orphanet:3398", source="Orphanet:3398/ntbt"} +xref: ICD10CM:D15.0 {source="Orphanet:3398", source="Orphanet:3398/ntbt", source="MONDO:directSiblingOf"} +xref: MESH:C536905 {source="Orphanet:3398", source="MONDO:equivalentTo", source="Orphanet:3398/e"} +xref: NCIT:C6450 {source="MONDO:equivalentTo"} +xref: ONCOTREE:TET {source="MONDO:equivalentTo"} +xref: Orphanet:3398 {source="MONDO:equivalentTo"} +xref: UMLS:C1266101 {source="NCIT:C6450", source="Orphanet:3398", source="MONDO:equivalentTo", source="Orphanet:3398/e"} +is_a: MONDO:0005197 {source="MONDO:Redundant", source="NCIT:C6450", source="ONCOTREE:TET", source="Orphanet:3398"} ! thymus neoplasm +is_a: MONDO:0005626 {source="MESH:C536905", source="MONDO:Redundant", source="NCIT:C6450"} ! epithelial neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch http://identifiers.org/mesh/C536905 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1266101 +property_value: exactMatch NCIT:C6450 +property_value: exactMatch Orphanet:3398 +property_value: narrowMatch https://icd.codes/icd10cm/C37 + +[Term] +id: MONDO:0018102 +name: corneal dystrophy +def: "The term corneal dystrophy embraces a heterogeneous group of bilateral genetically determined non-inflammatory corneal diseases that are usually restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value." [Orphanet:34533] +comment: Editor note: NCIT distinguishes between acquired and genetic +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:34533"} +synonym: "corneal dystrophy" EXACT [MONDO:ambiguous] +synonym: "corneal dystrophy (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:2566 {source="MONDO:equivalentTo"} +xref: HP:0001131 {source="MONDO:otherHierarchy"} +xref: ICD9:371.5 {source="DOID:2566"} +xref: ICD9:371.50 {source="DOID:2566"} +xref: MedDRA:10011005 {source="Orphanet:34533", source="Orphanet:34533/e"} +xref: MESH:D003317 {source="Orphanet:34533", source="MONDO:equivalentTo", source="DOID:2566", source="Orphanet:34533/e"} +xref: NCIT:C34513 {source="MONDO:equivalentTo", source="DOID:2566"} +xref: Orphanet:34533 {source="MONDO:equivalentTo"} +xref: SCTID:5587004 {source="MONDO:equivalentTo", source="DOID:2566"} +xref: UMLS:C0010036 {source="Orphanet:34533", source="MONDO:equivalentTo", source="DOID:2566", source="Orphanet:34533/e", source="NCIT:C34513"} +is_a: MONDO:0000942 {source="DOID:2566", source="MESH:D003317", source="NCIT:C34513/inferred"} ! corneal disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0015107"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10011005 +property_value: exactMatch DOID:2566 +property_value: exactMatch http://identifiers.org/mesh/D003317 +property_value: exactMatch http://identifiers.org/snomedct/5587004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0010036 +property_value: exactMatch NCIT:C34513 +property_value: exactMatch Orphanet:34533 +property_value: IAO:0000589 "corneal dystrophy (disease)" xsd:string + +[Term] +id: MONDO:0018106 +name: hereditary xanthinuria +def: "Hereditary xanthinuria is a purine metabolism disorder due to inherited deficiency of the xanthine dehydrogenase/oxidase enzyme and is characterized by very low (or undetectable) concentrations of uric acid in blood and urine and very high concentration of xanthine in urine, leading to urolithiasis." [Orphanet:3467] +subset: ordo_disease {source="Orphanet:3467"} +synonym: "classic xanthinuria" EXACT [Orphanet:3467] +synonym: "hereditary xanthinuria" EXACT [MONDO:patterns/hereditary] +synonym: "xanthic urolithiasis" EXACT [Orphanet:3467] +synonym: "xanthine dehydrogenase deficiency" EXACT [DOID:0060236] +synonym: "xanthine stone disease" EXACT [Orphanet:3467] +synonym: "xanthinuria" RELATED [DOID:0060236] +xref: DOID:0060236 {source="MONDO:equivalentTo"} +xref: HP:0010934 {source="MONDO:otherHierarchy", source="DOID:0060236"} +xref: ICD10CM:E79.8 {source="Orphanet:3467/inclusion", source="Orphanet:3467/ntbt", source="Orphanet:3467"} +xref: ICD9:277.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: OMIM:278300 {source="Orphanet:3467/btnt", source="Orphanet:3467", source="DOID:0060236"} +xref: OMIM:603592 {source="Orphanet:3467/btnt", source="Orphanet:3467", source="DOID:0060236"} +xref: OMIMPS:278300 {source="MONDO:equivalentTo"} +xref: Orphanet:3467 {source="MONDO:equivalentTo", source="DOID:0060236"} +xref: SCTID:54627004 {source="MONDO:equivalentTo"} +is_a: MONDO:0000721 {source="MONDO:Redundant", source="MONDO:cjm"} ! xanthinuria +is_a: MONDO:0019236 {source="Orphanet:3467"} ! inborn disorder of purine metabolism +is_a: MONDO:0019743 {source="Orphanet:3467"} ! nephropathy secondary to a storage or other metabolic disease +intersection_of: MONDO:0000721 ! xanthinuria +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:0060236 +property_value: exactMatch http://identifiers.org/snomedct/54627004 +property_value: exactMatch https://omim.org/phenotypicSeries/PS278300 +property_value: exactMatch Orphanet:3467 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E79.8 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0018121 +name: mitochondrial DNA maintenance syndrome +def: "An acquired metabolic disease that is has its basis in the disruption of mitochondrial genome maintenance." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:352456"} +synonym: "inborn error of mitochondrial genome maintenance" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn mitochondrial genome maintenance disorder" EXACT [] +synonym: "mtDNA maintenance syndrome" EXACT [Orphanet:352456] +synonym: "rare inborn error of mitochondrial genome maintenance" EXACT [MONDO:patterns/inborn_metabolic] +xref: Orphanet:352456 {source="MONDO:equivalentTo"} +xref: UMLS:CN204491 {source="MONDO:equivalentTo"} +is_a: MONDO:0016387 {source="Orphanet:352456"} ! mitochondrial oxidative phosphorylation disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0000002 ! mitochondrial genome maintenance +relationship: disease_has_basis_in_disruption_of GO:0000002 ! mitochondrial genome maintenance +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204491 +property_value: exactMatch Orphanet:352456 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0018171 +name: malignant germ cell tumor of ovary +def: "Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen." [Orphanet:35807] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:35807"} +synonym: "malignant germ cell neoplasm of ovary" EXACT [NCIT:C4514] +synonym: "malignant germ cell neoplasm of the ovary" EXACT [NCIT:C4514] +synonym: "malignant germ cell tumor of ovary" EXACT [NCIT:C4514] +synonym: "malignant germ cell tumor of the ovary" EXACT [NCIT:C4514] +synonym: "malignant ovarian germ cell neoplasm" EXACT [MONDO:0002231, NCIT:C4514] +synonym: "malignant ovarian germ cell tumor" EXACT [DOID:2155, NCIT:C4514, Orphanet:35807] +synonym: "MOGCT" EXACT ABBREVIATION [Orphanet:35807] +synonym: "ovarian germ cell cancer" EXACT [NCIT:C4514, Orphanet:35807] +synonym: "ovary malignant germ cell tumor" EXACT [MONDO:patterns/location] +xref: DOID:2155 {source="MONDO:equivalentTo"} +xref: ICD10CM:C56 {source="Orphanet:35807", source="Orphanet:35807/ntbt"} +xref: NCIT:C4514 {source="DOID:2155", source="MONDO:equivalentTo"} +xref: Orphanet:35807 {source="MONDO:equivalentTo"} +xref: SCTID:254869000 {source="DOID:2155", source="MONDO:equivalentTo"} +xref: UMLS:C0346180 {source="DOID:2155", source="MONDO:equivalentTo", source="Orphanet:35807", source="NCIT:C4514"} +is_a: MONDO:0006290 {source="MONDO:Redundant", source="NCIT:C4514"} ! malignant germ cell tumor +is_a: MONDO:0011366 {source="DOID:2155", source="MONDO:Redundant", source="NCIT:C4514"} ! ovarian germ cell tumor +is_a: MONDO:0018202 {source="Orphanet:35807"} ! gonadal germ cell tumor +is_a: MONDO:0018365 {source="Orphanet:35807"} ! malignant non-epithelial tumor of ovary +intersection_of: MONDO:0006290 ! malignant germ cell tumor +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:2155 +property_value: exactMatch http://identifiers.org/snomedct/254869000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346180 +property_value: exactMatch NCIT:C4514 +property_value: exactMatch Orphanet:35807 +property_value: narrowMatch https://icd.codes/icd10cm/C56 + +[Term] +id: MONDO:0018172 +name: malignant sex cord stromal tumor of ovary +def: "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis." [Orphanet:35808] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:35808"} +synonym: "malignant ovarian SCST" EXACT [Orphanet:35808] +synonym: "malignant ovarian Sex cord-stromal neoplasm" EXACT [NCIT:C8053] +synonym: "malignant ovarian Sex cord-stromal tumor" EXACT [NCIT:C8053] +synonym: "malignant ovarian sex cord-stromal tumor" EXACT [Orphanet:35808] +synonym: "malignant Sex cord-stromal tumor of ovary" EXACT [NCIT:C8053] +synonym: "malignant Sex cord-stromal tumor of the ovary" EXACT [NCIT:C8053] +synonym: "ovarian sex cord-stromal tumor, malignant" EXACT [MONDO:patterns/malignant] +xref: ICD10CM:C56 {source="Orphanet:35808/ntbt", source="Orphanet:35808"} +xref: NCIT:C8053 {source="MONDO:equivalentTo"} +xref: Orphanet:35808 {source="MONDO:equivalentTo"} +xref: UMLS:C1334609 {source="MONDO:equivalentTo", source="NCIT:C8053"} +xref: UMLS:CN204631 {source="MONDO:equivalentTo"} +is_a: MONDO:0018365 {source="Orphanet:35808"} ! malignant non-epithelial tumor of ovary +is_a: MONDO:0021657 {source="MONDO:Redundant", source="NCIT:C8053"} ! ovarian sex cord-stromal tumor +intersection_of: MONDO:0021657 ! ovarian sex cord-stromal tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334609 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204631 +property_value: exactMatch NCIT:C8053 +property_value: exactMatch Orphanet:35808 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C56 + +[Term] +id: MONDO:0018174 +name: hereditary glaucoma +def: "Hereditary glaucoma is a clinically diverse group of rare eye disorders with genetic predisposition characterized by elevated intraocular pressure (IOP) and glaucomatous changes of the optic nerve head, leading to field defects, visual loss and blindness. Hereditary glaucoma can be sub-classified as primary (congenital glaucoma, juvenile glaucoma) or secondary according to the presence or absence of systemic or other ocular anomalies (iridogoniodysgenesis, Stickler syndrome, Coats syndrome). The clinical presentation is variable and is based on age, severity of glaucoma, presence of ocular abnormalities and development of secondary IOP related abnormalities." [Orphanet:359] +subset: disease_grouping +subset: gard_rare {source="GARD:0002486"} +subset: ordo_group_of_disorders {source="Orphanet:359"} +synonym: "glaucoma, hereditary" RELATED [GARD:0002486] +synonym: "hereditary glaucoma (disease)" EXACT [MONDO:patterns/hereditary] +xref: GARD:0002486 {source="MONDO:equivalentTo"} +xref: MESH:C580055 {source="MONDO:equivalentTo"} +xref: Orphanet:359 {source="MONDO:equivalentTo"} +xref: UMLS:CN227278 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005041 {source="MESH:C580055", source="MONDO:Redundant", source="MONDO:cjm"} ! glaucoma +intersection_of: MONDO:0005041 ! glaucoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/C580055 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227278 +property_value: exactMatch Orphanet:359 +property_value: excluded_subClassOf MONDO:0015217 {source="Orphanet:359"} +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/2486/glaucoma-hereditary xsd:anyURI {source="GARD:0002486"} + +[Term] +id: MONDO:0018177 +name: glioblastoma +def: "The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)" [NCIT:C3058] +subset: ordo_disease {source="Orphanet:360"} +synonym: "GBM" EXACT ABBREVIATION [DOID:3068, NCIT:C3058, Orphanet:360] +synonym: "GBM (glioblastoma)" EXACT [DOID:3068, NCIT:C3058] +synonym: "giant cell glioblastoma (histologic variant)" RELATED [GARD:0002491] +synonym: "glioblastoma" EXACT [MONDO:ambiguous, NCIT:C3058] +synonym: "glioblastoma (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "glioblastoma multiforme" EXACT [NCIT:C3058, Orphanet:360] +synonym: "glioblastoma multiforme (disease)" EXACT [MONDO:0002498] +synonym: "gliosarcoma (histologic variant)" RELATED [GARD:0002491] +synonym: "grade IV adult astrocytic tumor" NARROW [DOID:3068, NCIT:C9094] +synonym: "grade IV astrocytic neoplasm" EXACT [NCIT:C3058] +synonym: "grade IV astrocytic tumor" EXACT [NCIT:C3058] +synonym: "grade IV astrocytoma" EXACT [NCIT:C3058] +synonym: "primary glioblastoma multiforme" EXACT [DOID:3068] +synonym: "spongioblastoma multiforme" EXACT [DOID:3068, NCIT:C3058] +synonym: "WHO grade IV glioma" EXACT [NCIT:C3058] +xref: DOID:3068 {source="MONDO:equivalentTo"} +xref: GARD:0002491 {source="MONDO:equivalentTo"} +xref: HP:0012174 {source="MONDO:otherHierarchy"} +xref: HP:0100843 {source="MONDO:otherHierarchy"} +xref: ICD10CM:C71.9 {source="Orphanet:360", source="Orphanet:360/ntbt"} +xref: ICDO:9440/3 {source="NCIT:C3058"} +xref: MedDRA:10018336 {source="Orphanet:360", source="Orphanet:360/e"} +xref: MedDRA:10018337 {source="Orphanet:360", source="Orphanet:360/e"} +xref: NCIT:C3058 {source="DOID:3068", source="MONDO:equivalentTo"} +xref: OMIM:137800 {source="MONDO:relatedTo", source="Orphanet:360", source="Orphanet:360/ntbt"} +xref: OMIM:613029 {source="MONDO:relatedTo", source="Orphanet:360", source="Orphanet:360/ntbt"} +xref: ONCOTREE:GB {source="MONDO:equivalentTo"} +xref: ONCOTREE:GBM {source="MONDO:equivalentTo"} +xref: Orphanet:360 {source="MONDO:equivalentTo"} +xref: SCTID:393563007 {source="MONDO:equivalentTo"} +xref: UMLS:C0017636 {source="DOID:3068", source="MONDO:equivalentTo", source="Orphanet:360", source="NCIT:C3058", source="Orphanet:360/e"} +xref: UMLS:C1621958 {source="MONDO:equivalentTo", source="Orphanet:360", source="Orphanet:360/e"} +xref: UMLS:CN227279 {source="MONDO:equivalentTo"} +is_a: MONDO:0016680 {source="NCIT:C3058", source="Orphanet:360"} ! high grade astrocytic tumor +relationship: has_modifier MONDO:0024494 {source="NCIT:C3058"} ! tumor grade 4, general grading system +property_value: closeMatch http://identifiers.org/meddra/10018336 +property_value: closeMatch http://identifiers.org/meddra/10018337 +property_value: exactMatch DOID:3068 +property_value: exactMatch http://identifiers.org/snomedct/393563007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017636 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1621958 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227279 +property_value: exactMatch NCIT:C3058 +property_value: exactMatch Orphanet:360 +property_value: IAO:0000589 "glioblastoma (disease)" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/C71.9 + +[Term] +id: MONDO:0018191 +name: tumor of testis and paratestis +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:363472"} +synonym: "testicular and paratesticular tumor" EXACT [Orphanet:363472] +xref: Orphanet:363472 {source="MONDO:equivalentTo"} +xref: UMLS:CN204698 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="Orphanet:363472"} ! neoplasm +relationship: has_modifier MONDO:0021136 {source="MONDO:0015931"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204698 +property_value: exactMatch Orphanet:363472 + +[Term] +id: MONDO:0018201 +name: extragonadal germ cell tumor +def: "A germ cell tumor arising in an anatomic site other than the testis or ovary (e.g., central nervous system, lung, mediastinum, and retroperitoneum)." [NCIT:C3918] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:363579"} +synonym: "extragonadal germ cell neoplasm" EXACT [NCIT:C3918] +synonym: "extragonadal germ cell neoplasms" EXACT [NCIT:C3918] +synonym: "extragonadal germ cell tumor" EXACT [NCIT:C3918] +synonym: "neoplasm of extragonadal germ cell" EXACT [NCIT:C3918] +synonym: "neoplasm of the extragonadal germ cell" EXACT [NCIT:C3918] +synonym: "primary extragonadal germ cell tumor" EXACT [NCIT:C3918] +synonym: "tumor of extragonadal germ cell" EXACT [NCIT:C3918] +synonym: "tumor of the extragonadal germ cell" EXACT [NCIT:C3918] +xref: GARD:0009325 {source="MONDO:equivalentTo"} +xref: NCIT:C3918 {source="MONDO:equivalentTo"} +xref: Orphanet:363579 {source="MONDO:equivalentTo"} +xref: UMLS:C0262963 {source="MONDO:equivalentTo"} +xref: UMLS:CN204711 {source="MONDO:equivalentTo"} +is_a: MONDO:0005040 {source="MONDO:0018201/inferred", source="NCIT:C3918", source="Orphanet:363579"} ! germ cell tumor +relationship: has_modifier MONDO:0021136 {source="MONDO:0018080"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0262963 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204711 +property_value: exactMatch NCIT:C3918 +property_value: exactMatch Orphanet:363579 + +[Term] +id: MONDO:0018202 +name: gonadal germ cell tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:363582"} +xref: Orphanet:363582 {source="MONDO:equivalentTo"} +xref: UMLS:CN204712 {source="MONDO:equivalentTo"} +is_a: MONDO:0005040 {source="Orphanet:363582"} ! germ cell tumor +relationship: has_modifier MONDO:0021136 {source="MONDO:0018080"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN204712 +property_value: exactMatch Orphanet:363582 + +[Term] +id: MONDO:0018215 +name: paraneoplastic neurologic syndrome +def: "A paraneoplastic syndrome that involves the nervous system." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:36388"} +synonym: "nervous system paraneoplastic syndrome" EXACT [MONDO:patterns/location] +synonym: "paraneoplastic cerebellar degeneration" NARROW [Orphanet:36388] +synonym: "paraneoplastic syndrome of nervous system" EXACT [MONDO:design_pattern] +synonym: "PCD" EXACT ABBREVIATION [Orphanet:36388] +synonym: "PNS" EXACT ABBREVIATION [Orphanet:36388] +xref: GARD:0007326 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD9:331.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10072106 {source="Orphanet:36388/e", source="Orphanet:36388"} +xref: Orphanet:36388 {source="MONDO:equivalentTo"} +xref: SCTID:192877007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 {source="Orphanet:36388"} ! nervous system disorder +is_a: MONDO:0021073 {source="MONDO:Redundant"} ! paraneoplastic syndrome +intersection_of: MONDO:0021073 ! paraneoplastic syndrome +intersection_of: disease_has_location UBERON:0001016 ! nervous system +relationship: has_modifier MONDO:0021136 {source="MONDO:0020009"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10072106 +property_value: exactMatch http://identifiers.org/snomedct/192877007 +property_value: exactMatch Orphanet:36388 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0018234 +name: dysostosis +def: "A group of disorders in which the skeletal involvement is predominantly manifested as abnormalities of individual bones or in a group of bones." [https://orcid.org/0000-0002-0736-9199, https://www.sciencedirect.com/topics/medicine-and-dentistry/dysostosis] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:364559"} +synonym: "dysostosis" EXACT [NCIT:C34560] +xref: DOID:1934 {source="MONDO:equivalentTo"} +xref: ICD9:756.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D004413 {source="MONDO:equivalentTo", source="DOID:1934"} +xref: NCIT:C34560 {source="MONDO:equivalentTo", source="DOID:1934"} +xref: Orphanet:364559 {source="MONDO:equivalentTo"} +xref: SCTID:109420003 {source="MONDO:equivalentTo", source="DOID:1934"} +xref: UMLS:C0013393 {source="NCIT:C34560", source="MONDO:equivalentTo", source="Orphanet:364559", source="DOID:1934"} +is_a: MONDO:0005497 {source="DOID:1934", source="MONDO:Redundant", source="Orphanet:364559"} ! bone development disease +intersection_of: MONDO:0005497 ! bone development disease +intersection_of: disease_disrupts GO:0001503 ! ossification +relationship: disease_disrupts GO:0001503 ! ossification +relationship: has_modifier MONDO:0021136 {source="MONDO:0015328", source="MONDO:0019684"} ! rare +property_value: exactMatch DOID:1934 +property_value: exactMatch http://identifiers.org/mesh/D004413 +property_value: exactMatch http://identifiers.org/snomedct/109420003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013393 +property_value: exactMatch NCIT:C34560 +property_value: exactMatch Orphanet:364559 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4994 xsd:string + +[Term] +id: MONDO:0018292 +name: congenital disorder of glycosylation-related bone disorder +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:371195"} +synonym: "CDG-related bone disorder" EXACT [Orphanet:371195] +xref: ICD10CM:E77.8 {source="Orphanet:371195/attributed", source="Orphanet:371195/ntbt", source="Orphanet:371195"} +xref: Orphanet:371195 {source="MONDO:equivalentTo"} +is_a: MONDO:0005381 {source="Orphanet:371195"} ! bone disorder +is_a: MONDO:0015286 ! congenital disorder of glycosylation +is_a: MONDO:0015327 ! developmental anomaly of metabolic origin +intersection_of: MONDO:0015286 ! congenital disorder of glycosylation +intersection_of: disease_has_major_feature HP:0000924 ! Abnormality of the skeletal system +relationship: disease_has_major_feature HP:0000924 ! Abnormality of the skeletal system +property_value: exactMatch Orphanet:371195 +property_value: narrowMatch https://icd.codes/icd10cm/E77.8 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0018351 +name: adenocarcinoma of penis +def: "A adenocarcinoma that involves the penis." [MONDO:patterns/location] +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: obsoletion_candidate +subset: ordo_disease {source="Orphanet:398053"} +synonym: "adenocarcinoma of the penis" RELATED [Orphanet:398053] +synonym: "penile adenocarcinoma" EXACT [NCIT:C27817, Orphanet:398053] +synonym: "penis adenocarcinoma" EXACT [MONDO:patterns/location] +xref: ICD10CM:C60.0 {source="Orphanet:398053/ntbt", source="Orphanet:398053"} +xref: ICD10CM:C60.1 {source="Orphanet:398053/ntbt", source="Orphanet:398053"} +xref: ICD10CM:C60.2 {source="Orphanet:398053/ntbt", source="Orphanet:398053"} +xref: ICD10CM:C60.8 {source="Orphanet:398053/ntbt", source="Orphanet:398053"} +xref: ICD10CM:C60.9 {source="Orphanet:398053/ntbt", source="Orphanet:398053"} +xref: Orphanet:398053 {source="MONDO:equivalentTo"} +is_a: MONDO:0004970 ! adenocarcinoma +is_a: MONDO:0006360 ! penile carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch Orphanet:398053 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: narrowMatch https://icd.codes/icd10cm/C60.0 +property_value: narrowMatch https://icd.codes/icd10cm/C60.1 +property_value: narrowMatch https://icd.codes/icd10cm/C60.2 +property_value: narrowMatch https://icd.codes/icd10cm/C60.8 +property_value: narrowMatch https://icd.codes/icd10cm/C60.9 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0018352 +name: squamous cell carcinoma of penis +def: "A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)" [NCIT:C7729] +subset: ordo_disease {source="Orphanet:398058"} +synonym: "epidermoid carcinoma of penis" EXACT [NCIT:C7729] +synonym: "epidermoid carcinoma of the penis" EXACT [NCIT:C7729] +synonym: "epidermoid cell carcinoma of penis" EXACT [DOID:5518, NCIT:C7729] +synonym: "epidermoid cell carcinoma of the penis" EXACT [NCIT:C7729] +synonym: "penile epidermoid carcinoma" EXACT [NCIT:C7729] +synonym: "penile epidermoid cell carcinoma" EXACT [NCIT:C7729] +synonym: "penile squamous car.(epidermoid)" EXACT [NCIT:C7729] +synonym: "penile squamous carcinoma (epidermoid)" EXACT [NCIT:C7729] +synonym: "penile squamous cell cancer" EXACT [NCIT:C7729] +synonym: "penile squamous cell carcinoma" EXACT [NCIT:C7729, Orphanet:398058] +synonym: "penis squamous cell carcinoma" EXACT [MONDO:0003484, MONDO:patterns/location] +synonym: "PSCC" RELATED ABBREVIATION [ONCOTREE:PSCC] +synonym: "squamous cell carcinoma of penis" EXACT [DOID:5518, NCIT:C7729] +synonym: "squamous cell carcinoma of the penis" EXACT [NCIT:C7729] +xref: DOID:5518 {source="MONDO:equivalentTo"} +xref: ICD10CM:C60.0 {source="Orphanet:398058", source="Orphanet:398058/ntbt"} +xref: ICD10CM:C60.1 {source="Orphanet:398058", source="Orphanet:398058/ntbt"} +xref: ICD10CM:C60.2 {source="Orphanet:398058", source="Orphanet:398058/ntbt"} +xref: ICD10CM:C60.8 {source="Orphanet:398058", source="Orphanet:398058/ntbt"} +xref: ICD10CM:C60.9 {source="Orphanet:398058", source="Orphanet:398058/ntbt"} +xref: NCIT:C7729 {source="MONDO:equivalentTo", source="DOID:5518"} +xref: ONCOTREE:PSCC {source="MONDO:equivalentTo"} +xref: Orphanet:398058 {source="MONDO:equivalentTo"} +xref: SCTID:403468003 {source="MONDO:equivalentTo", source="DOID:5518"} +xref: UMLS:C0238348 {source="Orphanet:398058", source="MONDO:equivalentTo", source="DOID:5518", source="NCIT:C7729"} +is_a: MONDO:0005096 {source="DOID:5518", source="MONDO:Redundant", source="NCIT:C7729"} ! squamous cell carcinoma +is_a: MONDO:0006360 {source="DOID:5518", source="MONDO:Redundant", source="NCIT:C7729"} ! penile carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch DOID:5518 +property_value: exactMatch http://identifiers.org/snomedct/403468003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238348 +property_value: exactMatch NCIT:C7729 +property_value: exactMatch Orphanet:398058 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C60.0 +property_value: narrowMatch https://icd.codes/icd10cm/C60.1 +property_value: narrowMatch https://icd.codes/icd10cm/C60.2 +property_value: narrowMatch https://icd.codes/icd10cm/C60.8 +property_value: narrowMatch https://icd.codes/icd10cm/C60.9 + +[Term] +id: MONDO:0018364 +name: malignant epithelial tumor of ovary +def: "An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor." [NCIT:C40026] +comment: Editor note: check inference with carcinoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:398934"} +synonym: "epithelial cancer of ovary" EXACT [Orphanet:398934] +synonym: "malignant ovarian epithelial tumor" EXACT [NCIT:C40026] +synonym: "malignant ovarian surface epithelial-stromal neoplasm" EXACT [DOID:2151, https://github.com/DiseaseOntology/HumanDiseaseOntology/issues/167, NCIT:C40026] +synonym: "malignant ovarian surface epithelial-stromal tumor" EXACT [NCIT:C40026] +synonym: "ovarian epithelial cancer" EXACT [Orphanet:398934] +synonym: "ovarian epithelial tumor, malignant" EXACT [MONDO:patterns/malignant] +synonym: "ovarian malignant epithelial tumor" EXACT [Orphanet:398934] +synonym: "ovarian stromal cancer" EXACT [NCIT:C40026] +xref: DOID:2151 {source="MONDO:equivalentTo"} +xref: GARD:0009362 {source="MONDO:equivalentTo"} +xref: MESH:C538090 {source="MONDO:equivalentTo"} +xref: NCIT:C40026 {source="MONDO:equivalentTo", source="DOID:2151"} +xref: Orphanet:398934 {source="MONDO:equivalentTo"} +xref: SCTID:254849005 {source="MONDO:equivalentTo"} +is_a: MONDO:0002229 {source="DOID:2151", source="MONDO:Redundant", source="NCIT:C40026"} ! ovarian epithelial tumor +is_a: MONDO:0004993 ! carcinoma +is_a: MONDO:0008170 {source="DOID:2151/inferred", source="MESH:C538090", source="MONDO:Redundant", source="NCIT:C40026", source="Orphanet:398934"} ! ovarian cancer +intersection_of: MONDO:0002229 ! ovarian epithelial tumor +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +disjoint_from: MONDO:0018365 ! malignant non-epithelial tumor of ovary +property_value: exactMatch DOID:2151 +property_value: exactMatch http://identifiers.org/mesh/C538090 +property_value: exactMatch http://identifiers.org/snomedct/254849005 +property_value: exactMatch NCIT:C40026 +property_value: exactMatch Orphanet:398934 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml + +[Term] +id: MONDO:0018365 +name: malignant non-epithelial tumor of ovary +comment: Editor note: consider axiomatizing. This includes sex-cord and germ cell. Note some GCTs have names suggesting epithelial original such as embryonal/choriocarcinoma +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:398940"} +synonym: "non-epithelial cancer of ovary" EXACT [Orphanet:398940] +synonym: "ovarian malignant non-epithelial tumor" EXACT [Orphanet:398940] +synonym: "ovarian non-epithelial cancer" EXACT [Orphanet:398940] +xref: Orphanet:398940 {source="MONDO:equivalentTo"} +xref: UMLS:CN205032 {source="MONDO:equivalentTo"} +is_a: MONDO:0008170 {source="Orphanet:398940"} ! ovarian cancer +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN205032 +property_value: exactMatch Orphanet:398940 + +[Term] +id: MONDO:0018454 +name: dysostosis of genetic origin +def: "An instance of dysostosis that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:404568"} +synonym: "genetic dysostosis" EXACT [MONDO:patterns/genetic] +xref: Orphanet:404568 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0018234 {source="MONDO:Redundant", source="MONDO:cjm"} ! dysostosis +intersection_of: MONDO:0018234 ! dysostosis +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch Orphanet:404568 + +[Term] +id: MONDO:0018502 +name: hereditary gastric cancer +def: "Hereditary gastric cancer refers to the occurrence of gastric cancer in a familial context and is described as two or more cases of gastric cancer in first or second degree relatives with at least one case diagnosed before the age of 50. Familial clustering is observed in 10% of all cases of gastric cancer, and includes hereditary diffuse gastric cancer (early onset diffuse-type gastric cancer), gastric adenocarcinoma and proximal polyposis of the stomach and familial intestinal gastric cancer (familial clustering of intestinal type gastric adenocarcinoma). Hereditary gastric cancer can also occur in other hereditary cancer syndromes such as Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis and juvenile polyposis syndrome." [Orphanet:423776] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:423776"} +synonym: "hereditary cancer of stomach" EXACT [Orphanet:423776] +synonym: "hereditary gastric cancer" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:423776 {source="MONDO:equivalentTo"} +is_a: MONDO:0004950 {source="Orphanet:423776"} ! gastric carcinoma +is_a: MONDO:0017128 ! inherited digestive tract tumor +intersection_of: MONDO:0001056 ! gastric cancer +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch Orphanet:423776 + +[Term] +id: MONDO:0018509 +name: squamous cell carcinoma of the small intestine +def: "A carcinoma that arises from the small intestine. It is composed of malignant squamous cells." [NCIT:C43534] +subset: ordo_disease {source="Orphanet:423968"} +synonym: "small intestinal squamous cell cancer" EXACT [NCIT:C43534] +synonym: "small intestinal squamous cell carcinoma" EXACT [NCIT:C43534] +synonym: "small intestine squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of the small bowel" EXACT [Orphanet:423968] +xref: NCIT:C43534 {source="MONDO:equivalentTo"} +xref: Orphanet:423968 {source="MONDO:equivalentTo"} +xref: UMLS:C1710111 {source="MONDO:equivalentTo", source="NCIT:C43534"} +xref: UMLS:CN237514 {source="MONDO:equivalentTo"} +is_a: MONDO:0005096 {source="MONDO:Redundant", source="NCIT:C43534"} ! squamous cell carcinoma +is_a: MONDO:0005522 {source="MONDO:Redundant", source="NCIT:C43534", source="Orphanet:423968"} ! small intestine carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0002108 ! small intestine +relationship: has_modifier MONDO:0021136 {source="MONDO:0018508"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1710111 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237514 +property_value: exactMatch NCIT:C43534 +property_value: exactMatch Orphanet:423968 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0018510 +name: small intestine neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the small intestine. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C5803] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:423975"} +synonym: "NET of the small intestine" EXACT [Orphanet:423975] +synonym: "neuroendocrine neoplasm of small intestine" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of the small intestine" EXACT [Orphanet:423975] +synonym: "neuroendocrine tumor of small bowel" EXACT [Orphanet:423975] +synonym: "neuroendocrine tumor of the small intestine" RELATED [Orphanet:423975] +synonym: "small intestinal neuroendocrine neoplasm" EXACT [NCIT:C5803] +synonym: "small intestine NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "small intestine neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C5803] +synonym: "small intestine neuroendocrine tumor" EXACT [DOID:4434, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "small intestine neuroendocrine tumor, well differentiated, low or intermediate grade" RELATED [MONDO:patterns/neuroendocrine_neoplasm] +xref: DOID:4434 {source="MONDO:equivalentTo"} +xref: NCIT:C5803 {source="DOID:4434", source="MONDO:equivalentTo"} +xref: Orphanet:423975 {source="MONDO:equivalentTo"} +xref: UMLS:C1336005 {source="DOID:4434", source="MONDO:equivalentTo", source="NCIT:C5803"} +xref: UMLS:CN237515 {source="MONDO:equivalentTo"} +is_a: MONDO:0002883 {source="DOID:4434", source="MONDO:Redundant", source="NCIT:C5803"} ! intestinal neuroendocrine neoplasm +is_a: MONDO:0004251 {source="DOID:4434", source="MONDO:0018539-obsoleted", source="MONDO:Redundant", source="NCIT:C5803"} ! small intestine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch DOID:4434 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237515 +property_value: exactMatch NCIT:C5803 +property_value: exactMatch Orphanet:423975 +property_value: excluded_subClassOf MONDO:0000956 {source="DOID:4434"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0018511 +name: epithelial tumor of the appendix +def: "A epithelial neoplasm that involves the vermiform appendix." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:423982"} +synonym: "appendiceal epithelial tumor" EXACT [Orphanet:423982] +synonym: "vermiform appendix epithelial neoplasm" EXACT [MONDO:patterns/location] +xref: Orphanet:423982 {source="MONDO:equivalentTo"} +xref: UMLS:CN237516 {source="MONDO:equivalentTo"} +is_a: MONDO:0001236 ! appendiceal neoplasm +is_a: MONDO:0024479 ! epithelial tumor of colon +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +relationship: has_modifier MONDO:0021136 {source="MONDO:0015186"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237516 +property_value: exactMatch Orphanet:423982 + +[Term] +id: MONDO:0018513 +name: squamous cell carcinoma of colon +def: "A squamous cell carcinoma that involves the colon." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:423994"} +synonym: "colon epidermoid carcinoma" EXACT [NCIT:C5490] +synonym: "colon squamous cell cancer" EXACT [NCIT:C5490] +synonym: "colon squamous cell carcinoma" EXACT [MONDO:0003485, MONDO:patterns/location, NCIT:C5490] +synonym: "colonic epidermoid carcinoma" EXACT [DOID:5519, NCIT:C5490] +synonym: "colonic squamous cell carcinoma" EXACT [NCIT:C5490] +synonym: "epidermoid carcinoma of colon" EXACT [NCIT:C5490] +synonym: "epidermoid carcinoma of the colon" EXACT [NCIT:C5490] +synonym: "squamous cell carcinoma of colon" EXACT [DOID:5519, NCIT:C5490] +synonym: "squamous cell carcinoma of the colon" EXACT [NCIT:C5490] +synonym: "squamous cell colon carcinoma" EXACT [NCIT:C5490] +xref: DOID:5519 {source="MONDO:equivalentTo"} +xref: NCIT:C5490 {source="MONDO:equivalentTo", source="DOID:5519"} +xref: Orphanet:423994 {source="MONDO:equivalentTo"} +xref: SCTID:766981007 {source="MONDO:equivalentTo"} +xref: UMLS:C1333100 {source="MONDO:equivalentTo", source="DOID:5519", source="NCIT:C5490"} +xref: UMLS:CN237518 {source="MONDO:equivalentTo"} +is_a: MONDO:0002032 {source="DOID:5519", source="MONDO:Redundant", source="NCIT:C5490"} ! colon carcinoma +is_a: MONDO:0006165 {source="MONDO:Redundant", source="NCIT:C5490"} ! colorectal squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001155 ! colon +relationship: has_modifier MONDO:0021136 {source="MONDO:0018512"} ! rare +property_value: exactMatch DOID:5519 +property_value: exactMatch http://identifiers.org/snomedct/766981007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333100 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237518 +property_value: exactMatch NCIT:C5490 +property_value: exactMatch Orphanet:423994 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0018515 +name: squamous cell carcinoma of rectum +def: "A very rare rectal carcinoma characterized by the presence of a malignant squamous cell infiltrate." [NCIT:C5554] +subset: ordo_disease {source="Orphanet:424002"} +synonym: "rectal squamous carcinoma" EXACT [NCIT:C5554] +synonym: "rectal squamous cell cancer" EXACT [NCIT:C5554] +synonym: "rectal squamous cell carcinoma" EXACT [NCIT:C5554, Orphanet:424002] +synonym: "rectum squamous cell carcinoma" EXACT [MONDO:0003491, MONDO:patterns/location] +synonym: "squamous carcinoma of rectum" EXACT [DOID:5528, NCIT:C5554] +synonym: "squamous carcinoma of the rectum" EXACT [NCIT:C5554] +synonym: "squamous cell carcinoma of rectum" EXACT [NCIT:C5554] +synonym: "squamous cell carcinoma of the rectum" EXACT [DOID:5528, NCIT:C5554] +xref: DOID:5528 {source="MONDO:equivalentTo"} +xref: ICD10CM:C20 {source="Orphanet:424002/ntbt", source="Orphanet:424002"} +xref: NCIT:C5554 {source="MONDO:equivalentTo", source="DOID:5528"} +xref: Orphanet:424002 {source="MONDO:equivalentTo"} +xref: SCTID:766979005 {source="MONDO:equivalentTo"} +xref: UMLS:C1335690 {source="MONDO:equivalentTo", source="NCIT:C5554", source="DOID:5528", source="Orphanet:424002"} +is_a: MONDO:0006165 {source="MONDO:Redundant", source="NCIT:C5554"} ! colorectal squamous cell carcinoma +is_a: MONDO:0044937 ! rectal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001052 ! rectum +relationship: has_modifier MONDO:0021136 {source="MONDO:0018514"} ! rare +property_value: exactMatch DOID:5528 +property_value: exactMatch http://identifiers.org/snomedct/766979005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335690 +property_value: exactMatch NCIT:C5554 +property_value: exactMatch Orphanet:424002 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C20 + +[Term] +id: MONDO:0018516 +name: epithelial tumor of anal canal +def: "A epithelial neoplasm that involves the anal canal." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:424010"} +synonym: "anal canal epithelial neoplasm" EXACT [MONDO:patterns/location] +xref: Orphanet:424010 {source="MONDO:equivalentTo"} +xref: UMLS:CN237521 {source="MONDO:equivalentTo"} +is_a: MONDO:0005626 ! epithelial neoplasm +is_a: MONDO:0021118 {source="Orphanet:424010"} ! intestinal neoplasm +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0000159 ! anal canal +relationship: disease_has_location UBERON:0000159 ! anal canal +relationship: has_modifier MONDO:0021136 {source="MONDO:0015186"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237521 +property_value: exactMatch Orphanet:424010 + +[Term] +id: MONDO:0018521 +name: squamous cell carcinoma of pancreas +def: "A squamous cell carcinoma that involves the pancreas." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:424039"} +synonym: "pancreas squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "pancreatic squamous cell carcinoma" EXACT [Orphanet:424039] +synonym: "squamous cell carcinoma of the pancreas" RELATED [Orphanet:424039] +xref: DOID:0080323 {source="MONDO:equivalentTo"} +xref: Orphanet:424039 {source="MONDO:equivalentTo"} +xref: UMLS:C2675993 {source="MONDO:equivalentTo"} +xref: UMLS:CN237524 {source="MONDO:equivalentTo"} +is_a: MONDO:0005096 ! squamous cell carcinoma +is_a: MONDO:0005192 {source="Orphanet:424039"} ! exocrine pancreatic carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001264 ! pancreas +relationship: has_modifier MONDO:0021136 {source="MONDO:0016314"} ! rare +property_value: exactMatch DOID:0080323 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2675993 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237524 +property_value: exactMatch Orphanet:424039 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0018531 +name: carcinoma of liver and intrahepatic biliary tract +def: "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma." [NCIT:C7927] +comment: Editor note: In uberon intrahepatic bile ducts are part of the liver, so we equate this with carcinoma of liver; we use hepatocellular for the liver proper +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:424936"} +synonym: "cancer of liver" BROAD [NCIT:C7927] +synonym: "cancer of liver and intrahepatic biliary tract" BROAD [NCIT:C7927] +synonym: "cancer of the liver" BROAD [NCIT:C7927] +synonym: "cancer of the liver and intrahepatic biliary tract" BROAD [NCIT:C7927] +synonym: "carcinoma of liver" BROAD [MONDO:patterns/carcinoma] +synonym: "carcinoma of liver and IBT" EXACT [Orphanet:424936] +synonym: "hepatic cancer" BROAD [NCIT:C7927] +synonym: "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma" RELATED [ONCOTREE:HCCIHCH] +synonym: "liver and intrahepatic bile duct cancer" BROAD [NCIT:C7927] +synonym: "liver and intrahepatic bile duct carcinoma" EXACT [NCIT:C7927] +synonym: "liver and intrahepatic biliary tract cancer" EXACT [NCIT:C7927] +synonym: "liver and intrahepatic biliary tract carcinoma" EXACT [NCIT:C7927] +synonym: "liver cancer" BROAD [NCIT:C7927] +synonym: "liver carcinoma" EXACT [MONDO:cjm] +synonym: "liver/hepatobiliary cancer" BROAD [NCIT:C7927] +synonym: "primary liver carcinoma" EXACT [NCIT:C7927] +xref: NCIT:C7927 {source="MONDO:equivalentTo"} +xref: ONCOTREE:HCCIHCH {source="MONDO:equivalentTo"} +xref: Orphanet:424936 {source="MONDO:equivalentTo"} +xref: UMLS:C0279000 {source="MONDO:equivalentTo", source="NCIT:C7927"} +is_a: MONDO:0002691 ! liver cancer +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C7927"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002107 ! liver +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279000 +property_value: exactMatch NCIT:C7927 +property_value: exactMatch Orphanet:424936 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0018532 +name: adenocarcinoma of liver and intrahepatic biliary tract +subset: ordo_disease {source="Orphanet:424943"} +synonym: "adenocarcinoma of liver and IBT" EXACT [Orphanet:424943] +synonym: "adenocarcinoma of the liver and IBT" EXACT [Orphanet:424943] +synonym: "adenocarcinoma of the liver and intrahepatic biliary tract" EXACT [Orphanet:424943] +xref: Orphanet:424943 {source="MONDO:equivalentTo"} +xref: UMLS:CN242181 {source="MONDO:equivalentTo"} +is_a: MONDO:0004970 ! adenocarcinoma +is_a: MONDO:0018531 {source="MONDO:Entailed", source="Orphanet:424943"} ! carcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: MONDO:0024477 ! liver and intrahepatic bile duct neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN242181 +property_value: exactMatch Orphanet:424943 + +[Term] +id: MONDO:0018534 +name: squamous cell carcinoma of liver and intrahepatic biliary tract +def: "Squamous cell carcinoma of liver and intrahepatic biliary tract is an extremely rare, primary, malignant liver and biliray tract epithelial tumor originating in the intrahepatic bile duct epithelium histologically characterized by the presence of keratinization and/or intracellular bridges. Patients typically present abdominal pain in the right upper quadrant, jaundice, nausea, vomiting, anorexia, weight loss, fever and/or dyspepsia." [Orphanet:424975] +subset: ordo_disease {source="Orphanet:424975"} +synonym: "squamous cell carcinoma of liver and IBT" EXACT [Orphanet:424975] +xref: Orphanet:424975 {source="MONDO:equivalentTo"} +xref: UMLS:CN242131 {source="MONDO:equivalentTo"} +is_a: MONDO:0005096 ! squamous cell carcinoma +is_a: MONDO:0018531 {source="MONDO:Entailed", source="Orphanet:424975"} ! carcinoma of liver and intrahepatic biliary tract +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: MONDO:0024477 ! liver and intrahepatic bile duct neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN242131 +property_value: exactMatch Orphanet:424975 + +[Term] +id: MONDO:0018536 +name: adenocarcinoma of gallbladder and extrahepatic biliary tract +def: "Adenocarcinoma of the gallbladder and extrahepatic biliary tract is a rare epithelial carcinoma, arising either in the gallbladder itself or from the epithelium lining the extrahepatic biliary tree, cystic duct and/or peribiliary gland, characterized by nonspecific symptoms, such as abdominal pain, jaundice and vomiting and sometimes mimicking benign biliary diseases. Chronic biliary epithelial inflammation (e.g. primary sclerosing cholangitis, cholelithiasis, choledocholithiasis, liver fluke infestation) is a major risk factor." [Orphanet:424991] +subset: ordo_disease {source="Orphanet:424991"} +synonym: "adenocarcinoma of gallbladder and EBT" EXACT [Orphanet:424991] +synonym: "adenocarcinoma of the gallbladder and EBT" EXACT [Orphanet:424991] +synonym: "adenocarcinoma of the gallbladder and extrahepatic biliary tract" EXACT [Orphanet:424991] +xref: Orphanet:424991 {source="MONDO:equivalentTo"} +xref: SCTID:765741003 {source="MONDO:equivalentTo"} +xref: UMLS:CN237537 {source="MONDO:equivalentTo"} +is_a: MONDO:0002665 ! extrahepatic bile duct adenocarcinoma +is_a: MONDO:0018918 {source="MONDO:Redundant", source="Orphanet:424991"} ! carcinoma of gallbladder and extrahepatic biliary tract +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: MONDO:0018918 ! carcinoma of gallbladder and extrahepatic biliary tract +property_value: exactMatch http://identifiers.org/snomedct/765741003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237537 +property_value: exactMatch Orphanet:424991 + +[Term] +id: MONDO:0018537 +name: squamous cell carcinoma of gallbladder and extrahepatic biliary tract +def: "Squamous cell carcinoma of the gallbladder and extrahepatic biliary tract is a rare hepatic and biliary tract tumor, arising either in the gallbladder itself or in the epithelium lining the extrahepatic biliary tree, the cystic duct and peribiliary glands. It is characterized by a substantial keratinization with abundant keratohyalin pearls and central deposition of dense keratin material within infiltrative nests and locally aggressive nature. In the early stages of the disease symptoms are vague and nonspecific (abdominal pain, jaundice and vomiting). In the advanced stages it may present with a bulky tumor and symptoms of adjacent organ involvement." [Orphanet:424996] +subset: ordo_disease {source="Orphanet:424996"} +synonym: "squamous cell carcinoma of gallblader and EBT" EXACT [Orphanet:424996] +xref: Orphanet:424996 {source="MONDO:equivalentTo"} +xref: SCTID:766978002 {source="MONDO:equivalentTo"} +xref: UMLS:CN237538 {source="MONDO:equivalentTo"} +is_a: MONDO:0006203 ! extrahepatic bile duct squamous cell carcinoma +is_a: MONDO:0018918 {source="MONDO:Redundant", source="Orphanet:424996"} ! carcinoma of gallbladder and extrahepatic biliary tract +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: MONDO:0018918 ! carcinoma of gallbladder and extrahepatic biliary tract +property_value: exactMatch http://identifiers.org/snomedct/766978002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237538 +property_value: exactMatch Orphanet:424996 + +[Term] +id: MONDO:0018538 +name: inherited digestive cancer-predisposing syndrome +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:425003"} +xref: Orphanet:425003 {source="MONDO:equivalentTo"} +xref: UMLS:CN237539 {source="MONDO:equivalentTo"} +is_a: MONDO:0015356 {source="MONDO:Redundant", source="Orphanet:425003"} ! hereditary neoplastic syndrome +intersection_of: MONDO:0015356 ! hereditary neoplastic syndrome +intersection_of: disease_has_feature MONDO:0002516 ! digestive system cancer +relationship: disease_has_feature MONDO:0002516 ! digestive system cancer +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237539 +property_value: exactMatch Orphanet:425003 + +[Term] +id: MONDO:0018555 +name: hypogonadotropic hypogonadism +def: "Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis." [NCIT:C113347] +subset: ordo_disease {source="Orphanet:432"} +synonym: "central hypogonadism" EXACT [NCIT:C113347] +synonym: "congenital idiopathic hypogonadotropic hypogonadism" NARROW [DOID:0090070] +synonym: "gonadotropic deficiency" EXACT [Orphanet:432] +synonym: "hypogonadism, hypogonadotropic" EXACT [] +synonym: "hypogonadotropic hypogonadism" EXACT [NCIT:C113347] +synonym: "hypogonadotropic hypogonadism with or without anosmia" EXACT [OMIMPS:147950] +synonym: "hypogonadotropism" RELATED [MONDO:0004228] +synonym: "isolated congenital gonadotropin deficiency" NARROW [DOID:0090070] +synonym: "isolated hypogonadotropic hypogonadism" RELATED [] +synonym: "low gonadotropins (secondary hypogonadism)" EXACT [] +synonym: "nIHH" EXACT [Orphanet:432] +synonym: "normosmic congenital hypogonadotropic hypogonadism" EXACT [Orphanet:432] +synonym: "Normosmic idiopathic hypogonadotropic hypogonadism" EXACT [Orphanet:432] +synonym: "secondary hypogonadism" EXACT [NCIT:C113347] +xref: DOID:0090070 {source="MONDO:equivalentTo"} +xref: DOID:7455 {source="MONDO:equivalentObsolete"} +xref: HP:0000044 {source="MONDO:otherHierarchy"} +xref: ICD10CM:E23.0 {source="MONDO:relatedTo", source="Orphanet:432/ntbt", source="DOID:0090070", source="Orphanet:432/inclusion", source="Orphanet:432"} +xref: ICD9:253.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C113347 {source="MONDO:equivalentTo"} +xref: OMIM:146110 {source="Orphanet:432/btnt"} +xref: OMIM:147950 {source="Orphanet:432/ntbt"} +xref: OMIM:244200 {source="Orphanet:432/btnt"} +xref: OMIM:308700 {source="Orphanet:432/btnt"} +xref: OMIM:610628 {source="Orphanet:432/btnt"} +xref: OMIM:612370 {source="Orphanet:432/btnt"} +xref: OMIM:612702 {source="Orphanet:432/btnt"} +xref: OMIM:614837 {source="Orphanet:432/btnt"} +xref: OMIM:614838 {source="Orphanet:432/btnt"} +xref: OMIM:614839 {source="Orphanet:432/btnt"} +xref: OMIM:614840 {source="Orphanet:432/btnt"} +xref: OMIM:614841 {source="Orphanet:432/btnt"} +xref: OMIM:614842 {source="Orphanet:432/btnt"} +xref: OMIM:614858 {source="Orphanet:432/btnt"} +xref: OMIM:614880 {source="Orphanet:432/btnt"} +xref: OMIM:615266 {source="Orphanet:432/btnt"} +xref: OMIM:615269 {source="Orphanet:432/btnt"} +xref: OMIM:615270 {source="Orphanet:432/btnt"} +xref: OMIMPS:147950 {source="MONDO:equivalentTo", source="DOID:0090070"} +xref: Orphanet:432 {source="MONDO:equivalentTo", source="DOID:0090070"} +xref: SCTID:33927004 {source="MONDO:equivalentTo"} +xref: UMLS:CN235466 {source="MONDO:equivalentTo"} +is_a: MONDO:0002146 {source="DOID:0090070", source="MONDO:Redundant", source="NCIT:C113347"} ! hypogonadism +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0002146 ! hypogonadism +intersection_of: disease_has_basis_in_disruption_of GO:0005183 ! gonadotropin hormone-releasing hormone activity +relationship: disease_has_basis_in_disruption_of GO:0005183 ! gonadotropin hormone-releasing hormone activity +property_value: exactMatch DOID:0090070 +property_value: exactMatch http://identifiers.org/snomedct/33927004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN235466 +property_value: exactMatch https://omim.org/phenotypicSeries/PS147950 +property_value: exactMatch NCIT:C113347 +property_value: exactMatch Orphanet:432 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0018640 +name: secondary vasculitis +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:445197"} +xref: Orphanet:445197 {source="MONDO:equivalentTo"} +is_a: MONDO:0018882 {source="Orphanet:445197"} ! vasculitis +property_value: exactMatch Orphanet:445197 + +[Term] +id: MONDO:0018675 +name: IgG4-related ophthalmic disorder +def: "A IgG4-related disease that involves the eye." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:449563"} +synonym: "eye IgG4-related disease" EXACT [MONDO:patterns/location] +synonym: "IgG4-related disease of eye" EXACT [] +xref: ICD10CM:H05.1 {source="Orphanet:449563", source="Orphanet:449563/ntbt"} +xref: Orphanet:449563 {source="MONDO:equivalentTo"} +xref: UMLS:CN237741 {source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="MONDO:0015937-obsoleted"} ! eye disorder +is_a: MONDO:0017287 {source="Orphanet:449563"} ! IgG4-related disease +intersection_of: MONDO:0017287 ! IgG4-related disease +intersection_of: disease_has_location UBERON:0000970 ! eye +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237741 +property_value: exactMatch Orphanet:449563 +property_value: narrowMatch https://icd.codes/icd10cm/H05.1 + +[Term] +id: MONDO:0018698 +name: hereditary neuroendocrine tumor of small intestine +def: "An instance of neuroendocrine tumor of the small intestine that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: ordo_disease {source="Orphanet:456333"} +synonym: "hereditary neuroendocrine tumor of small bowel" EXACT [Orphanet:456333] +synonym: "hereditary neuroendocrine tumor of the small intestine" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary small intestine neuroendocrine neoplasm" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:456333 {source="MONDO:equivalentTo"} +xref: UMLS:CN237770 {source="MONDO:equivalentTo"} +xref: UMLS:CN847586 {source="MONDO:equivalentTo"} +is_a: MONDO:0017128 ! inherited digestive tract tumor +is_a: MONDO:0018510 ! small intestine neuroendocrine neoplasm +is_a: MONDO:0018538 {source="Orphanet:456333"} ! inherited digestive cancer-predisposing syndrome +is_a: MONDO:0025511 ! inherited neuroendocrine tumor +intersection_of: MONDO:0018510 ! small intestine neuroendocrine neoplasm +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN237770 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN847586 +property_value: exactMatch Orphanet:456333 + +[Term] +id: MONDO:0018738 +name: benign metanephric tumour +def: "A benign neoplasm that involves the metanephros." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:464359"} +xref: ICD10CM:D30.0 {source="Orphanet:464359", source="Orphanet:464359/ntbt"} +xref: Orphanet:464359 {source="MONDO:equivalentTo"} +xref: UMLS:CN242075 {source="MONDO:equivalentTo"} +is_a: MONDO:0002513 ! kidney benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000081 ! metanephros +relationship: disease_has_location UBERON:0000081 ! metanephros +relationship: has_modifier MONDO:0021136 {source="MONDO:0019749"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN242075 +property_value: exactMatch Orphanet:464359 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml +property_value: narrowMatch https://icd.codes/icd10cm/D30.0 + +[Term] +id: MONDO:0018751 +name: genetic otorhinolaryngologic disease +def: "An instance of otorhinolaryngologic disease that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0024623 otorhinolaryngologic disease +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:466084"} +synonym: "genetic otorhinolaryngologic disease" EXACT [MONDO:patterns/genetic] +xref: Orphanet:466084 {source="MONDO:equivalentTo"} +xref: UMLS:CN242186 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0024623 ! otorhinolaryngologic disease +intersection_of: MONDO:0024623 ! otorhinolaryngologic disease +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0021198"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN242186 +property_value: exactMatch Orphanet:466084 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0018771 +name: congenital anomaly of ventricular septum +def: "A congenital heart malformation that involves the interventricular septum." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:474347"} +synonym: "congenital anomaly of interventricular communication" EXACT [Orphanet:474347] +synonym: "congenital heart malformation of interventricular septum" EXACT [MONDO:design_pattern] +synonym: "congenital ventricular septal anomaly" EXACT [Orphanet:474347] +synonym: "interventricular septum congenital heart malformation" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "rare congenital anomaly of ventricular septum" RELATED [Orphanet:474347] +xref: Orphanet:474347 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 ! heart disorder +is_a: MONDO:0019512 {source="MONDO:Redundant", source="Orphanet:474347"} ! congenital heart malformation +intersection_of: MONDO:0019512 ! congenital heart malformation +intersection_of: disease_has_location UBERON:0002094 ! interventricular septum +relationship: disease_has_location UBERON:0002094 ! interventricular septum +relationship: has_modifier MONDO:0021140 {source="https://orcid.org/0000-0002-4142-7153"} ! congenital +property_value: exactMatch Orphanet:474347 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0018837 +name: postinfectious vasculitis +def: "Vasculitis, characterized by inflammatory lesions in the wall of vessels, may be due to different viruses." [Orphanet:48435] +subset: ordo_disease {source="Orphanet:48435"} +xref: ICD10CM:I77.6 {source="Orphanet:48435/ntbt", source="Orphanet:48435"} +xref: Orphanet:48435 {source="MONDO:equivalentTo"} +xref: SCTID:724063005 {source="MONDO:equivalentTo"} +xref: UMLS:C4510302 {source="MONDO:equivalentTo"} +is_a: MONDO:0018640 {source="Orphanet:48435"} ! secondary vasculitis +is_a: MONDO:0021669 ! post-infectious disorder +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_arises_from_feature MONDO:0005550 ! infectious disease +property_value: exactMatch http://identifiers.org/snomedct/724063005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4510302 +property_value: exactMatch Orphanet:48435 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml +property_value: narrowMatch https://icd.codes/icd10cm/I77.6 + +[Term] +id: MONDO:0018882 +name: vasculitis +def: "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. BehC'et disease) to relatively minor skin disease." [Orphanet:52759] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:52759"} +synonym: "angiitis" RELATED [DOID:865] +synonym: "systemic vasculitis" NARROW [Orphanet:52759] +xref: DOID:865 {source="MONDO:equivalentTo", source="EFO:0006803"} +xref: EFO:0006803 {source="MONDO:equivalentTo"} +xref: GARD:0009565 {source="MONDO:equivalentTo"} +xref: MedDRA:10036023 {source="Orphanet:52759/e", source="Orphanet:52759"} +xref: MedDRA:10047115 {source="Orphanet:52759/e", source="Orphanet:52759"} +xref: MESH:D014657 {source="Orphanet:52759/e", source="DOID:865", source="MONDO:equivalentTo", source="EFO:0006803", source="Orphanet:52759"} +xref: NCIT:C26912 {source="DOID:865", source="MONDO:equivalentTo", source="EFO:0006803", source="MONDO:exact-label-match"} +xref: Orphanet:52759 {source="MONDO:equivalentTo"} +xref: SCTID:31996006 {source="DOID:865", source="MONDO:equivalentTo", source="EFO:0006803"} +xref: UMLS:C0042384 {source="Orphanet:52759/e", source="DOID:865", source="MONDO:equivalentTo", source="Orphanet:52759", source="NCIT:C26912"} +xref: Wikipedia:Vasculitis {source="EFO:0006803"} +is_a: MONDO:0005385 {source="Orphanet:52759"} ! vascular disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002049 ! vasculature +relationship: disease_has_inflammation_site UBERON:0002049 ! vasculature +relationship: has_modifier MONDO:0021136 {source="MONDO:0019048"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10036023 +property_value: closeMatch http://identifiers.org/meddra/10047115 +property_value: exactMatch DOID:865 +property_value: exactMatch http://identifiers.org/mesh/D014657 +property_value: exactMatch http://identifiers.org/snomedct/31996006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042384 +property_value: exactMatch NCIT:C26912 +property_value: exactMatch Orphanet:52759 + +[Term] +id: MONDO:0018908 +name: non-Hodgkin lymphoma +def: "Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage." [NCIT:C3211] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:547"} +synonym: "NHL" EXACT ABBREVIATION [NCIT:C3211, Orphanet:547] +synonym: "non-Hodgkin lymphoma" EXACT [NCIT:C3211] +synonym: "non-Hodgkin's lymphoma" EXACT [NCIT:C3211] +synonym: "non-Hodgkin's lymphoma (NHL)" EXACT [NCIT:C3211] +synonym: "non-Hodgkins lymphoma" EXACT [MONDO:0005587] +xref: DOID:0060060 {source="EFO:0005952", source="MONDO:equivalentTo"} +xref: EFO:0005952 {source="MONDO:equivalentTo"} +xref: ICDO:9591/3 {source="NCIT:C3211"} +xref: MedDRA:10029547 {source="Orphanet:547", source="Orphanet:547/e"} +xref: MESH:D008228 {source="Orphanet:547", source="MONDO:equivalentTo", source="Orphanet:547/e"} +xref: NCIT:C3211 {source="EFO:0005952", source="MONDO:equivalentTo"} +xref: OMIM:605027 {source="Orphanet:547/btnt", source="Orphanet:547", source="DOID:0060060"} +xref: ONCOTREE:NHL {source="MONDO:equivalentTo"} +xref: Orphanet:547 {source="MONDO:equivalentTo"} +xref: UMLS:C0024305 {source="Orphanet:547", source="MONDO:equivalentTo", source="NCIT:C3211", source="Orphanet:547/e"} +is_a: MONDO:0005062 {source="DOID:0060060", source="EFO:0005952", source="MESH:D008228", source="NCIT:C3211", source="Orphanet:547"} ! lymphoma +property_value: closeMatch http://identifiers.org/meddra/10029547 +property_value: exactMatch DOID:0060060 +property_value: exactMatch http://identifiers.org/mesh/D008228 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024305 +property_value: exactMatch NCIT:C3211 +property_value: exactMatch Orphanet:547 + +[Term] +id: MONDO:0018918 +name: carcinoma of gallbladder and extrahepatic biliary tract +def: "Carcinoma of the gallbladder (GBC) is the most common and aggressive form of biliary tract cancer (BTC) usually arising in the fundus of the gallbladder, rapidly metastasizing to lymph nodes and distant sites." [Orphanet:56044] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:56044"} +synonym: "carcinoma of gallbladder and EBT" EXACT [Orphanet:56044] +xref: MedDRA:10007426 {source="Orphanet:56044/e", source="Orphanet:56044"} +xref: Orphanet:56044 {source="MONDO:equivalentTo"} +xref: UMLS:CN205299 {source="MONDO:equivalentTo"} +is_a: MONDO:0021385 {source="MONDO:0017631-obsoleted"} ! extrahepatic bile duct neoplasm +property_value: closeMatch http://identifiers.org/meddra/10007426 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN205299 +property_value: exactMatch Orphanet:56044 + +[Term] +id: MONDO:0019003 +name: multiple endocrine neoplasia type 2 +def: "Multiple endocrine neoplasia type 2 (MEN2) is a multiple endocrine neoplasia, a polyglandular cancer syndrome characterized by the occurrence of medullary thyroid carcinoma (MTC), pheochromocytoma (PCC), in one variant, primary hyperparathyroidism (PHPT). There are three forms: MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC)." [Orphanet:653] +subset: gard_rare {source="GARD:0003830"} +subset: ordo_disease {source="Orphanet:653"} +synonym: "MEN2" EXACT ABBREVIATION [Orphanet:653] +synonym: "multiple endocrine neoplasia type 2" EXACT [NCIT:C123329] +xref: GARD:0003830 {source="MONDO:equivalentTo"} +xref: ICD10CM:D44.8 {source="Orphanet:653", source="Orphanet:653/attributed", source="Orphanet:653/ntbt"} +xref: ICD9:194.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:258.02 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10028191 {source="Orphanet:653", source="Orphanet:653/e"} +xref: NCIT:C123329 {source="MONDO:equivalentTo"} +xref: OMIM:155240 {source="Orphanet:653", source="Orphanet:653/btnt"} +xref: OMIM:162300 {source="Orphanet:653", source="Orphanet:653/btnt"} +xref: OMIM:171400 {source="Orphanet:653", source="Orphanet:653/btnt"} +xref: Orphanet:653 {source="MONDO:equivalentTo"} +xref: SCTID:61808009 {source="MONDO:equivalentTo"} +xref: UMLS:C4048306 {source="NCIT:C123329", source="MONDO:equivalentTo"} +xref: UMLS:CN073359 {source="MONDO:equivalentTo"} +is_a: MONDO:0015075 {source="MONDO:Entailed", source="Orphanet:653"} ! thyroid gland carcinoma +is_a: MONDO:0017169 {source="NCIT:C123329", source="Orphanet:653"} ! multiple endocrine neoplasia +is_a: MONDO:0018538 {source="Orphanet:653"} ! inherited digestive cancer-predisposing syndrome +property_value: closeMatch http://identifiers.org/meddra/10028191 +property_value: exactMatch http://identifiers.org/snomedct/61808009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4048306 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN073359 +property_value: exactMatch NCIT:C123329 +property_value: exactMatch Orphanet:653 +property_value: narrowMatch https://icd.codes/icd10cm/D44.8 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/3830/multiple-endocrine-neoplasia-type-2 xsd:anyURI {source="GARD:0003830"} + +[Term] +id: MONDO:0019044 +name: tumor of hematopoietic and lymphoid tissues +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68347"} +xref: Orphanet:68347 {source="MONDO:equivalentTo"} +xref: UMLS:CN205528 {source="MONDO:equivalentTo"} +is_a: MONDO:0002334 ! hematopoietic and lymphoid system neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN205528 +property_value: exactMatch Orphanet:68347 + +[Term] +id: MONDO:0019050 +name: inherited hemoglobinopathy +def: "An inherited disorder characterized by structural alterations of a globin chain within the hemoglobin molecule." [NCIT:C3092] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68364"} +synonym: "hemoglobinopathies" EXACT [DOID:2860] +synonym: "Hemoglobinopathies / iron metabolism" EXACT [NCIT:C3092] +synonym: "hemoglobinopathy" RELATED [DOID:2860] +synonym: "hereditary hemoglobinopathy" EXACT [MONDO:patterns/hereditary] +xref: DOID:2860 {source="MONDO:equivalentTo"} +xref: GARD:0012455 {source="MONDO:equivalentTo"} +xref: ICD10CM:D56.0 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.1 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.2 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.3 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.4 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.8 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D56.9 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D57.0 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D57.1 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D57.2 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D57.3 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D57.8 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D58.0 {source="MONDO:relatedTo", source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D58.1 {source="MONDO:relatedTo", source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D58.2 {source="DOID:2860", source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D58.8 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD10CM:D58.9 {source="Orphanet:68364", source="Orphanet:68364/btnt"} +xref: ICD9:282.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10060892 {source="Orphanet:68364/e", source="Orphanet:68364"} +xref: MESH:D006453 {source="Orphanet:68364/e", source="DOID:2860", source="MONDO:equivalentTo", source="Orphanet:68364"} +xref: NCIT:C3092 {source="DOID:2860", source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: Orphanet:68364 {source="MONDO:equivalentTo"} +xref: SCTID:427306008 {source="MONDO:equivalentTo"} +xref: UMLS:C0019045 {source="Orphanet:68364/e", source="DOID:2860", source="MONDO:equivalentTo", source="Orphanet:68364", source="NCIT:C3092"} +xref: UMLS:C1960031 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0044348 {source="MONDO:Redundant"} ! hemoglobinopathy +intersection_of: MONDO:0044348 ! hemoglobinopathy +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: broadMatch https://icd.codes/icd10cm/D56.1 +property_value: broadMatch https://icd.codes/icd10cm/D56.4 +property_value: broadMatch https://icd.codes/icd10cm/D56.8 +property_value: broadMatch https://icd.codes/icd10cm/D56.9 +property_value: broadMatch https://icd.codes/icd10cm/D57.0 +property_value: broadMatch https://icd.codes/icd10cm/D57.1 +property_value: broadMatch https://icd.codes/icd10cm/D57.2 +property_value: broadMatch https://icd.codes/icd10cm/D57.3 +property_value: broadMatch https://icd.codes/icd10cm/D57.8 +property_value: broadMatch https://icd.codes/icd10cm/D58.2 +property_value: broadMatch https://icd.codes/icd10cm/D58.8 +property_value: broadMatch https://icd.codes/icd10cm/D58.9 +property_value: closeMatch http://identifiers.org/meddra/10060892 +property_value: exactMatch DOID:2860 +property_value: exactMatch http://identifiers.org/mesh/D006453 +property_value: exactMatch http://identifiers.org/snomedct/427306008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0019045 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1960031 +property_value: exactMatch NCIT:C3092 +property_value: exactMatch Orphanet:68364 +property_value: excluded_subClassOf MONDO:0003689 {source="DOID:2860"} + +[Term] +id: MONDO:0019052 +name: inborn errors of metabolism +def: "An inherited disorder resulting from an enzyme defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or organelle function." [https://github.com/monarch-initiative/mondo/issues/1483, MONDO:cjm, NCIT:C34816] +comment: Note that the ordo class is specifically for rare diseases, but we broaden to be inclusive of HH1 +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68367"} +synonym: "congenital metabolic disorder" EXACT [NCIT:C34816] +synonym: "congenital metabolism disorder" EXACT [NCIT:C34816] +synonym: "hereditary metabolic disease" EXACT [MONDO:patterns/hereditary] +synonym: "inborn disorders of metabolism" EXACT [https://orcid.org/0000-0001-6330-7526] +synonym: "inborn error of metabolism" EXACT [NCIT:C34816] +synonym: "inborn errors of metabolism" EXACT [DOID:655, NCIT:C34816] +synonym: "inborn metabolic disorder" EXACT [https://orcid.org/0000-0001-6330-7526] +synonym: "inborn metabolism disorder" EXACT [DOID:655] +synonym: "inherited disorder of metabolism" EXACT [https://orcid.org/0000-0002-0736-9199] +synonym: "inherited disorders of metabolism" EXACT [https://orcid.org/0000-0002-0736-9199] +synonym: "inherited metabolic disorder" EXACT [MONDO:0003919] +synonym: "metabolic hereditary disorder" EXACT [DOID:655] +synonym: "rare inborn errors of metabolism" NARROW [Orphanet:68367] +synonym: "rare inherited metabolic disorder" NARROW [] +synonym: "rare metabolic disease" RELATED [Orphanet:68367] +xref: DOID:655 {source="MONDO:equivalentTo"} +xref: MedDRA:10058097 {source="Orphanet:68367/e", source="Orphanet:68367"} +xref: MedDRA:10062018 {source="Orphanet:68367/e", source="Orphanet:68367"} +xref: MESH:D008661 {source="DOID:655", source="Orphanet:68367/e", source="MONDO:equivalentTo", source="Orphanet:68367"} +xref: NCIT:C34816 {source="DOID:655", source="MONDO:equivalentTo"} +xref: Orphanet:68367 {source="MONDO:equivalentTo"} +xref: SCTID:86095007 {source="DOID:655", source="MONDO:equivalentTo"} +xref: UMLS:C0025521 {source="DOID:655", source="NCIT:C34816", source="Orphanet:68367/e", source="MONDO:equivalentTo", source="Orphanet:68367"} +is_a: MONDO:0003847 {source="MESH:D008661", source="MONDO:Redundant", source="Orphanet:68367"} ! Mendelian disease +is_a: MONDO:0005066 {source="DOID:655", source="MESH:D008661", source="MONDO:Redundant", source="NCIT:C34816"} ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: closeMatch http://identifiers.org/meddra/10058097 +property_value: closeMatch http://identifiers.org/meddra/10062018 +property_value: exactMatch DOID:655 +property_value: exactMatch http://identifiers.org/mesh/D008661 +property_value: exactMatch http://identifiers.org/snomedct/86095007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0025521 +property_value: exactMatch NCIT:C34816 +property_value: exactMatch Orphanet:68367 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/1483 xsd:string + +[Term] +id: MONDO:0019053 +name: peroxisomal disease +def: "A group of congenital disorders of lipid metabolism, caused by loss of the normal peroxisomes. Signs and symptoms include developmental delays, mental retardation, facial abnormalities, hepatomegaly, and hypotonia." [NCIT:C85005] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68373"} +synonym: "disorder of peroxisomal function" EXACT [NCIT:C85005] +synonym: "peroxisomal disease" EXACT [NCIT:C85005] +synonym: "peroxisomal disorder" EXACT [DOID:906, ICD9CM:277.86, NCIT:C85005] +synonym: "peroxisomal function disorder" EXACT [NCIT:C85005] +xref: DOID:906 {source="MONDO:equivalentTo"} +xref: ICD9:277.86 {source="MONDO:equivalentTo", source="MONDO:i2s", source="DOID:906"} +xref: ICD9:277.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C85005 {source="MONDO:equivalentTo", source="DOID:906"} +xref: Orphanet:68373 {source="MONDO:equivalentTo"} +xref: SCTID:238059005 {source="MONDO:equivalentTo", source="DOID:906"} +xref: UMLS:C0282528 {source="MONDO:equivalentTo", source="Orphanet:68373", source="DOID:906", source="Orphanet:68373/e", source="NCIT:C85005"} +is_a: MONDO:0019052 {source="DOID:906", source="MONDO:Redundant", source="NCIT:C85005", source="Orphanet:68373"} ! inborn errors of metabolism +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0100033 {source="https://orcid.org/0000-0001-8486-0558"} ! metabolic epilepsy +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_dysfunction_of GO:0005777 ! peroxisome +relationship: disease_has_basis_in_dysfunction_of GO:0005777 ! peroxisome +property_value: exactMatch DOID:906 +property_value: exactMatch http://identifiers.org/snomedct/238059005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0282528 +property_value: exactMatch NCIT:C85005 +property_value: exactMatch Orphanet:68373 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml + +[Term] +id: MONDO:0019056 +name: neuromuscular disease +def: "Any disease that impairs the functioning of the muscles, either directly, being pathologies of the voluntary muscle, or indirectly, being pathologies of nerves or neuromuscular junctions" [Wikipedia:Neuromuscular_disease] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68381"} +synonym: "nerve and muscle disorder" EXACT [ISBN-13:978-1-259-64403-0] +synonym: "neuromuscular disease" EXACT [MONDO:0002986] +xref: DOID:440 {source="MONDO:equivalentTo"} +xref: EFO:1001902 {source="MONDO:equivalentTo"} +xref: ICD9:358 {source="DOID:440"} +xref: ICD9:358.9 {source="DOID:440"} +xref: MedDRA:10029323 {source="Orphanet:68381", source="Orphanet:68381/e"} +xref: MESH:D009468 {source="MONDO:equivalentTo", source="Orphanet:68381", source="DOID:440", source="Orphanet:68381/e"} +xref: Orphanet:68381 {source="MONDO:equivalentTo"} +xref: UMLS:C0027868 {source="MONDO:equivalentTo", source="Orphanet:68381", source="DOID:440", source="Orphanet:68381/e"} +is_a: MONDO:0005071 {source="ISBN-13:978-1-259-64403-0"} ! nervous system disorder +intersection_of: MONDO:0005071 ! nervous system disorder +intersection_of: disease_disrupts GO:0050905 ! neuromuscular process +relationship: disease_disrupts GO:0050905 ! neuromuscular process +property_value: closeMatch http://identifiers.org/meddra/10029323 +property_value: exactMatch DOID:440 +property_value: exactMatch http://identifiers.org/mesh/D009468 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027868 +property_value: exactMatch Orphanet:68381 + +[Term] +id: MONDO:0019060 +name: bone neoplasm +def: "A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage." [NCIT:C9343] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:68411"} +synonym: "bone neoplasm" EXACT [NCIT:C9343] +synonym: "bone neoplasms" EXACT [NCIT:C9343] +synonym: "bone tissue neoplasm" EXACT [] +synonym: "bone tissue tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "bone tumor" EXACT [NCIT:C9343] +synonym: "bone tumors" EXACT [NCIT:C9343] +synonym: "neoplasm of bone" EXACT [NCIT:C9343] +synonym: "neoplasm of bone tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the bone" EXACT [NCIT:C9343] +synonym: "osseous neoplasm" EXACT [NCIT:C9343] +synonym: "osseous tumor" EXACT [NCIT:C9343] +synonym: "primary bone cancer" RELATED [GARD:0013223] +synonym: "primary malignant neoplasm of bone" RELATED [GARD:0013223] +synonym: "rare bone tumor" RELATED [Orphanet:68411] +synonym: "tumor of bone" EXACT [NCIT:C9343] +synonym: "tumor of bone tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the bone" EXACT [NCIT:C9343] +xref: GARD:0013223 {source="MONDO:equivalentTo"} +xref: NCIT:C9343 {source="MONDO:equivalentTo"} +xref: ONCOTREE:BONE {source="MONDO:equivalentTo"} +xref: Orphanet:68411 {source="MONDO:equivalentTo"} +is_a: MONDO:0005381 {source="MONDO:Redundant", source="Orphanet:68411"} ! bone disorder +is_a: MONDO:0021581 ! connective tissue neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +relationship: has_modifier MONDO:0021136 {source="MONDO:0019684", source="MONDO:0020031"} ! rare +property_value: exactMatch NCIT:C9343 +property_value: exactMatch Orphanet:68411 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0019086 +name: carcinoma of esophagus +def: "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)." [Orphanet:70482] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:70482"} +synonym: "cancer of esophagus" NARROW [DOID:1107, NCIT:C3513] +synonym: "cancer of oesophagus" NARROW [DOID:1107] +synonym: "cancer of the esophagus" NARROW [NCIT:C3513] +synonym: "carcinoma of esophagus" EXACT [DOID:1107, MONDO:patterns/carcinoma, MTH:NOCODE, NCIT:C3513] +synonym: "carcinoma of oesophagus" EXACT [DOID:1107] +synonym: "carcinoma of the esophagus" EXACT [NCIT:C3513] +synonym: "esophageal cancer" NARROW [NCIT:C3513] +synonym: "esophageal cancer, NOS" NARROW [NCIT:C3513] +synonym: "esophageal carcinoma" EXACT [MONDO:0001189, NCIT:C3513, Orphanet:70482] +synonym: "esophagus carcinoma" EXACT [MONDO:patterns/location, NCIT:C3513] +xref: DOID:1107 {source="MONDO:equivalentTo"} +xref: EFO:0002916 {source="MONDO:equivalentTo", source="DOID:1107"} +xref: MedDRA:10030155 {source="Orphanet:70482", source="Orphanet:70482/e"} +xref: NCIT:C3513 {source="MONDO:equivalentTo", source="DOID:1107"} +xref: Orphanet:70482 {source="MONDO:equivalentTo"} +xref: SCTID:372138000 {source="MONDO:equivalentTo", source="DOID:1107"} +xref: UMLS:C0152018 {source="Orphanet:70482", source="MONDO:equivalentTo", source="Orphanet:70482/e", source="DOID:1107", source="NCIT:C3513"} +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C3513"} ! digestive system carcinoma +is_a: MONDO:0007576 {source="DOID:1107", source="MONDO:Redundant", source="NCIT:C3513"} ! esophageal cancer +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: closeMatch http://identifiers.org/meddra/10030155 +property_value: exactMatch DOID:1107 +property_value: exactMatch http://identifiers.org/snomedct/372138000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0152018 +property_value: exactMatch NCIT:C3513 +property_value: exactMatch Orphanet:70482 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0019087 +name: cholangiocarcinoma +def: "A carcinoma that arises from the intrahepatic biliary tree (intrahepatic cholangiocarcinoma) or from the junction, or adjacent to the junction, of the right and left hepatic ducts (hilar cholangiocarcinoma). Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor." [NCIT:C4436] +subset: ordo_disease {source="Orphanet:70567"} +synonym: "adult primary cholangiocarcinoma" EXACT [DOID:4947, NCIT:C8265] +synonym: "adult primary cholangiocellular carcinoma" EXACT [DOID:4947] +synonym: "bile duct cancer" BROAD [Orphanet:70567] +synonym: "CC" EXACT ABBREVIATION [NCIT:C4436] +synonym: "CCA" EXACT ABBREVIATION [Orphanet:70567] +synonym: "Cholangiocar.- intra/extrahepatic" EXACT [NCIT:C4436] +synonym: "cholangiocarcinoma" EXACT [NCIT:C4436] +synonym: "cholangiocarcinoma, intrahepatic and extrahepatic bile ducts (adenocarcinoma)" EXACT [NCIT:C4436] +synonym: "cholangiocarcinoma, malignant" EXACT [NCIT:C4436] +synonym: "Cholangiocellular carcinoma" EXACT [NCIT:C4436] +synonym: "cholangiosarcoma" EXACT [DOID:4947, NCIT:C4436] +synonym: "intrahepatic bile duct cancer (cholangiocarcinoma)" BROAD [NCIT:C4436] +xref: DOID:4947 {source="MONDO:equivalentTo", source="EFO:0005221"} +xref: EFO:0005221 {source="MONDO:equivalentTo"} +xref: GARD:0009304 {source="MONDO:equivalentTo"} +xref: ICD10CM:C24.0 {source="Orphanet:70567", source="Orphanet:70567/btnt"} +xref: ICD10CM:C24.8 {source="Orphanet:70567", source="Orphanet:70567/btnt"} +xref: ICD10CM:C24.9 {source="Orphanet:70567", source="Orphanet:70567/btnt"} +xref: ICDO:8160/3 {source="NCIT:C4436"} +xref: MedDRA:10004593 {source="Orphanet:70567", source="Orphanet:70567/e"} +xref: MedDRA:10008593 {source="Orphanet:70567", source="Orphanet:70567/e"} +xref: MESH:D018281 {source="MONDO:equivalentTo", source="Orphanet:70567", source="DOID:4947", source="EFO:0005221", source="Orphanet:70567/e"} +xref: NCIT:C4436 {source="MONDO:equivalentTo", source="DOID:4947", source="EFO:0005221"} +xref: OMIM:615619 {source="Orphanet:70567", source="Orphanet:70567/btnt"} +xref: ONCOTREE:CHOL {source="MONDO:equivalentTo"} +xref: Orphanet:70567 {source="MONDO:equivalentTo"} +xref: SCTID:312104005 {source="MONDO:equivalentTo", source="DOID:4947"} +xref: UMLS:C0206698 {source="MONDO:equivalentTo", source="Orphanet:70567", source="DOID:4947", source="NCIT:C4436", source="Orphanet:70567/e"} +is_a: MONDO:0018536 ! adenocarcinoma of gallbladder and extrahepatic biliary tract +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure UBERON:0002394 ! bile duct +relationship: disease_arises_from_structure UBERON:0002394 ! bile duct +property_value: broadMatch https://icd.codes/icd10cm/C24.0 +property_value: broadMatch https://icd.codes/icd10cm/C24.8 +property_value: broadMatch https://icd.codes/icd10cm/C24.9 +property_value: closeMatch http://identifiers.org/meddra/10004593 +property_value: closeMatch http://identifiers.org/meddra/10008593 +property_value: exactMatch DOID:4947 +property_value: exactMatch http://identifiers.org/mesh/D018281 +property_value: exactMatch http://identifiers.org/snomedct/312104005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206698 +property_value: exactMatch NCIT:C4436 +property_value: exactMatch Orphanet:70567 + +[Term] +id: MONDO:0019112 +name: cancer-associated retinopathy +def: "Cancer associated retinopathy (CAR) is a paraneoplastic disease of the eye associated with the presence of extraocular malignancy and circulating autoantibodies against retinal proteins." [Orphanet:71505] +subset: ordo_disease {source="Orphanet:71505"} +synonym: "CAR syndrome" EXACT [Orphanet:71505] +synonym: "paraneoplastic retinopathy" EXACT [Orphanet:71505] +xref: ICD9:362.10 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D059545 {source="MONDO:equivalentTo"} +xref: Orphanet:71505 {source="MONDO:equivalentTo"} +xref: SCTID:404663008 {source="MONDO:equivalentTo"} +is_a: MONDO:0005283 ! retinal disorder +is_a: MONDO:0018215 {source="Orphanet:71505"} ! paraneoplastic neurologic syndrome +intersection_of: MONDO:0005283 ! retinal disorder +intersection_of: disease_arises_from_feature MONDO:0004992 ! cancer +relationship: disease_arises_from_feature MONDO:0004992 ! cancer +property_value: exactMatch http://identifiers.org/mesh/D059545 +property_value: exactMatch http://identifiers.org/snomedct/404663008 +property_value: exactMatch Orphanet:71505 + +[Term] +id: MONDO:0019117 +name: genetic nervous system disorder +def: "An instance of nervous system disease that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005071 nervous system disorder +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:71859"} +synonym: "genetic nervous system disorder" EXACT [MONDO:patterns/genetic] +synonym: "genetic neurological disorder" EXACT [MONDO:cjm] +synonym: "rare genetic neurological disorder" EXACT [Orphanet:71859] +xref: Orphanet:71859 {source="MONDO:equivalentTo"} +xref: UMLS:CN205639 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005071 ! nervous system disorder +intersection_of: MONDO:0005071 ! nervous system disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0021198", source="Orphanet:71859"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN205639 +property_value: exactMatch Orphanet:71859 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0019127 +name: polymyositis +def: "Polymyositis (PM) is a rare idiopathic inflammatory myopathy characterized by symmetric proximal muscle weakness and elevated muscle enzymes." [Orphanet:732] +subset: ordo_disease {source="Orphanet:732"} +synonym: "PM" EXACT ABBREVIATION [Orphanet:732] +synonym: "polymyositis" EXACT [MONDO:0005234] +xref: EFO:0003063 {source="MONDO:equivalentTo"} +xref: GARD:0007425 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD10CM:M33.2 {source="Orphanet:732", source="MONDO:equivalentTo", source="Orphanet:732/e"} +xref: ICD9:710.4 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:0003063"} +xref: MedDRA:10036102 {source="Orphanet:732", source="Orphanet:732/e"} +xref: MESH:D017285 {source="Orphanet:732", source="MONDO:equivalentTo", source="Orphanet:732/e", source="EFO:0003063"} +xref: NCIT:C26925 {source="MONDO:equivalentTo", source="EFO:0003063"} +xref: Orphanet:732 {source="MONDO:equivalentTo"} +xref: SCTID:31384009 {source="MONDO:equivalentTo", source="EFO:0003063"} +xref: UMLS:C0085655 {source="Orphanet:732", source="MONDO:equivalentTo", source="Orphanet:732/e", source="NCIT:C26925"} +xref: Wikipedia:Polymyositis {source="EFO:0003063"} +is_a: MONDO:0019724 {source="Orphanet:732"} ! secondary glomerular disease +is_a: MONDO:0020122 {source="Orphanet:732"} ! acquired idiopathic inflammatory myopathy +property_value: closeMatch http://identifiers.org/meddra/10036102 +property_value: exactMatch http://identifiers.org/mesh/D017285 +property_value: exactMatch http://identifiers.org/snomedct/31384009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085655 +property_value: exactMatch https://icd.codes/icd10cm/M33.2 +property_value: exactMatch NCIT:C26925 +property_value: exactMatch Orphanet:732 + +[Term] +id: MONDO:0019146 +name: inherited susceptibility to mycobacterial diseases +def: "Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare immunodeficiency syndrome, characterized by a narrow vulnerability to poorly virulent mycobacteria, such as bacillus Calmette-Guerin (BCG) vaccines and environmental mycobacteria (EM), and defined by severe, recurrent infections, either disseminated or localized." [Orphanet:748] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:748"} +subset: predisposition +synonym: "idiopathic infection caused by BCG or atypical mycobacteria" EXACT [Orphanet:748] +synonym: "Mendelian susceptibility to atypical mycobacteria" EXACT [Orphanet:748] +synonym: "Mendelian susceptibility to mycobacterial infections" EXACT [Orphanet:748] +synonym: "MSMD" EXACT ABBREVIATION [Orphanet:748] +synonym: "Mycobacterium caused genetic susceptibility to infections due to particular pathogens" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Mycobacterium genetic susceptibility to infections due to particular pathogens" EXACT [] +xref: GARD:0012977 {source="MONDO:equivalentTo"} +xref: ICD10CM:D84.8 {source="Orphanet:748", source="Orphanet:748/attributed", source="Orphanet:748/ntbt"} +xref: Orphanet:748 {source="MONDO:equivalentTo"} +xref: UMLS:C3266863 {source="MONDO:equivalentTo", source="Orphanet:748"} +xref: UMLS:CN181681 {source="MONDO:equivalentTo"} +is_a: MONDO:0015979 {source="Orphanet:748"} ! hereditary predisposition to infections +intersection_of: MONDO:0015979 ! hereditary predisposition to infections +intersection_of: disease_has_infectious_agent NCBITaxon:1763 ! Mycobacterium +relationship: disease_has_infectious_agent NCBITaxon:1763 ! Mycobacterium +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3266863 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN181681 +property_value: exactMatch Orphanet:748 +property_value: narrowMatch https://icd.codes/icd10cm/D84.8 + +[Term] +id: MONDO:0019189 +name: inborn disorder of amino acid and other organic acid metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79062"} +synonym: "disorder of amino acid and organic acid metabolism" EXACT [] +synonym: "disorder of amino acid and other organic acid metabolism" RELATED [Orphanet:79062] +xref: ICD9:270.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:79062 {source="MONDO:equivalentTo"} +xref: SCTID:237911005 {source="MONDO:equivalentTo"} +xref: UMLS:C0342666 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 {source="MONDO:Redundant", source="Orphanet:79062"} ! inborn errors of metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_disrupts GO:0006082 ! organic acid metabolic process +relationship: disease_disrupts GO:0006082 ! organic acid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/237911005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342666 +property_value: exactMatch Orphanet:79062 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0019210 +name: cutaneous neuroendocrine carcinoma +def: "Cutaneous neuroendocrine carcinoma is a primary cutaneous cancer arising from a subset of skin neuroendocrine cells (Merkel cells, giving the name Merkel cell carcinoma (MCC))." [Orphanet:79140] +subset: ordo_disease {source="Orphanet:79140"} +synonym: "carcinoma of Merkel cell" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, Merkel cell" RELATED [GARD:0009266] +synonym: "cutaneous APUDoma" EXACT [NCIT:C9231] +synonym: "cutaneous neuroendocrine carcinoma" EXACT [NCIT:C9231] +synonym: "MCC" EXACT ABBREVIATION [ONCOTREE:MCC, Orphanet:79140] +synonym: "Merkel cell cancer" EXACT [NCIT:C9231] +synonym: "Merkel cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C9231, Orphanet:79140] +synonym: "Merkel cell tumor" EXACT [NCIT:C9231] +synonym: "Merkle tumors" RELATED [GARD:0009266] +synonym: "neuroendocrine carcinoma of skin" EXACT [NCIT:C9231] +synonym: "neuroendocrine carcinoma of the skin" EXACT [NCIT:C9231] +synonym: "neuroendocrine skin carcinoma" EXACT [NCIT:C9231] +synonym: "trabecular cancer" EXACT [NCIT:C9231] +synonym: "trabecular skin carcinoma" EXACT [NCIT:C9231] +xref: EFO:1001471 {source="MONDO:equivalentTo"} +xref: GARD:0009266 {source="MONDO:equivalentTo"} +xref: ICD10CM:C44.3 {source="Orphanet:79140", source="Orphanet:79140/btnt"} +xref: ICD10CM:C44.6 {source="Orphanet:79140", source="Orphanet:79140/btnt"} +xref: ICD10CM:C44.7 {source="Orphanet:79140", source="Orphanet:79140/btnt"} +xref: ICD9:209.36 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8247/3 {source="NCIT:C9231"} +xref: MESH:D015266 {source="MONDO:equivalentTo"} +xref: NCIT:C9231 {source="MONDO:equivalentTo"} +xref: ONCOTREE:MCC {source="MONDO:equivalentTo"} +xref: Orphanet:79140 {source="MONDO:equivalentTo"} +xref: SCTID:253001006 {source="MONDO:equivalentTo"} +xref: UMLS:C0007129 {source="MONDO:equivalentTo", source="Orphanet:79140", source="NCIT:C9231"} +is_a: MONDO:0002120 {source="MESH:D015266", source="MONDO:Redundant", source="NCIT:C9231"} ! neuroendocrine carcinoma +is_a: MONDO:0002656 {source="MONDO:Redundant", source="NCIT:C9231"} ! skin carcinoma +is_a: MONDO:0003363 {source="MONDO:Entailed", source="NCIT:C9231"} ! malignant dermis tumor +is_a: MONDO:0005872 ! nervous system cancer +is_a: MONDO:0017341 {source="Orphanet:79140"} ! virus associated tumor +is_a: MONDO:0021635 {source="Wikipedia:Neurocristopathy"} ! neurocristopathy +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location CL:0000242 ! Merkel cell +relationship: disease_has_location CL:0000242 ! Merkel cell +property_value: broadMatch https://icd.codes/icd10cm/C44.3 +property_value: broadMatch https://icd.codes/icd10cm/C44.6 +property_value: broadMatch https://icd.codes/icd10cm/C44.7 +property_value: exactMatch http://identifiers.org/mesh/D015266 +property_value: exactMatch http://identifiers.org/snomedct/253001006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007129 +property_value: exactMatch NCIT:C9231 +property_value: exactMatch Orphanet:79140 +property_value: excluded_subClassOf MONDO:0019300 {source="Orphanet:79140"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0019213 +name: cerebral organic aciduria +def: "A inherited organic acidemia that involves the brain." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79158"} +synonym: "brain inherited organic acidemia" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "inherited organic acidemia of brain" EXACT [MONDO:design_pattern] +xref: Orphanet:79158 {source="MONDO:equivalentTo"} +is_a: MONDO:0000688 {source="MONDO:Redundant", source="Orphanet:79158"} ! inherited organic acidemia +is_a: MONDO:0005560 ! brain disorder +is_a: MONDO:0019117 ! genetic nervous system disorder +intersection_of: MONDO:0000688 ! inherited organic acidemia +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch Orphanet:79158 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0019214 +name: inborn carbohydrate metabolic disorder +def: "An acquired metabolic disease that is has its basis in the disruption of carbohydrate metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79161"} +synonym: "carbohydrate metabolic disorder" RELATED [DOID:2978] +synonym: "carbohydrate metabolism disorder" EXACT [NCIT:C97089] +synonym: "disorder of carbohydrate metabolism" RELATED [Orphanet:79161] +synonym: "disorder of carbohydrate transport and metabolism" EXACT [DOID:2978] +synonym: "inborn carbohydrate metabolic process disorder" EXACT [] +synonym: "inborn carbohydrate metabolism disorder" EXACT [DOID:2978] +synonym: "inborn error of carbohydrate metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn errors of carbohydrate metabolism" EXACT [DOID:2978] +synonym: "rare inborn error of carbohydrate metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:2978 {source="MONDO:equivalentTo"} +xref: EFO:1000061 {source="MONDO:equivalentTo"} +xref: ICD9:271.8 {source="DOID:2978"} +xref: MedDRA:10061023 {source="Orphanet:79161", source="Orphanet:79161/e"} +xref: MESH:D002239 {source="MONDO:equivalentTo", source="DOID:2978"} +xref: NCIT:C97089 {source="MONDO:equivalentTo"} +xref: Orphanet:79161 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 {source="DOID:2978", source="MESH:D002239", source="MONDO:Redundant", source="Orphanet:79161"} ! inborn errors of metabolism +is_a: MONDO:0037792 ! carbohydrate metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0005975 ! carbohydrate metabolic process +property_value: closeMatch http://identifiers.org/meddra/10061023 +property_value: exactMatch DOID:2978 +property_value: exactMatch http://identifiers.org/mesh/D002239 +property_value: exactMatch NCIT:C97089 +property_value: exactMatch Orphanet:79161 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019218 +name: inborn disorder of bile acid synthesis +def: "Anomalies of bile acid synthesis are a group of sterol metabolism disorders due to enzyme deficiencies of bile acid synthesis (BAS) in infants, children and adults, with variable manifestations that include cholestasis, neurological disease, and fat malabsorption. Nine inborn errors have been described, 7 of which lead to liver cholestasis." [Orphanet:79168] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79168"} +synonym: "disorder of bile acid synthesis" RELATED [Orphanet:79168] +synonym: "inborn bile acid biosynthetic process disorder" EXACT [] +synonym: "inborn error of bile acid biosynthetic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn errors of bile acid synthesis" RELATED [GTR:AN0923838] +synonym: "rare inborn error of bile acid biosynthetic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: GTR:AN0923838 {source="UMLS:CN544763"} +xref: Orphanet:79168 {source="MONDO:equivalentTo"} +xref: UMLS:CN231736 {source="MONDO:equivalentTo"} +xref: UMLS:CN544763 {source="MONDO:equivalentTo"} +is_a: MONDO:0000688 ! inherited organic acidemia +is_a: MONDO:0019256 {source="Orphanet:79168"} ! sterol metabolism disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006699 ! bile acid biosynthetic process +relationship: disease_has_basis_in_disruption_of GO:0006699 ! bile acid biosynthetic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN231736 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN544763 +property_value: exactMatch Orphanet:79168 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019222 +name: inborn disorder of methionine cycle and sulfur amino acid metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of sulfur amino acid metabolic process." [MONDO:patterns/inborn_metabolic] +comment: Editor note: check this +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79173"} +synonym: "cytosolic methyl group transfer or sulfur amino acid metabolism disorder" EXACT [Orphanet:79173] +synonym: "disorder of methionine cycle and sulfur amino acid metabolism" RELATED [Orphanet:79173] +synonym: "inborn error of sulfur amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn sulfur amino acid metabolic process disorder" EXACT [] +synonym: "rare inborn error of sulfur amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E72.1 {source="Orphanet:79173", source="Orphanet:79173/attributed", source="Orphanet:79173/ntbt"} +xref: ICD9:270.4 {source="MONDO:i2s"} +xref: Orphanet:79173 {source="MONDO:equivalentTo"} +xref: SCTID:28882002 {source="MONDO:equivalentTo"} +xref: UMLS:CN227589 {source="MONDO:equivalentTo"} +is_a: MONDO:0000688 ! inherited organic acidemia +is_a: MONDO:0056803 ! sulfur metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0000096 ! sulfur amino acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0000096 ! sulfur amino acid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/28882002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227589 +property_value: exactMatch Orphanet:79173 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E72.1 + +[Term] +id: MONDO:0019225 +name: gluconeogenesis disorder +def: "An acquired metabolic disease that is has its basis in the disruption of gluconeogenesis." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79177"} +synonym: "inborn error of gluconeogenesis" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn gluconeogenesis disorder" EXACT [] +synonym: "rare inborn error of gluconeogenesis" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E74.4 {source="Orphanet:79177", source="Orphanet:79177/attributed", source="Orphanet:79177/ntbt"} +xref: Orphanet:79177 {source="MONDO:equivalentTo"} +xref: UMLS:CN227592 {source="MONDO:equivalentTo"} +is_a: MONDO:0002908 ! glucose metabolism disease +is_a: MONDO:0019214 {source="MONDO:Redundant", source="Orphanet:79177"} ! inborn carbohydrate metabolic disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006094 ! gluconeogenesis +relationship: disease_has_basis_in_disruption_of GO:0006094 ! gluconeogenesis +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227592 +property_value: exactMatch Orphanet:79177 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E74.4 + +[Term] +id: MONDO:0019226 +name: glucose transport disorder +def: "An acquired metabolic disease that is has its basis in the disruption of glucose transport." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79178"} +synonym: "inborn error of glucose transport" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "rare inborn error of glucose transport" RELATED [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E74.8 {source="Orphanet:79178/attributed", source="Orphanet:79178/ntbt", source="Orphanet:79178"} +xref: Orphanet:79178 {source="MONDO:equivalentTo"} +xref: UMLS:CN227593 {source="MONDO:equivalentTo"} +is_a: MONDO:0017706 {source="Orphanet:79178"} ! disorder of carbohydrate absorption and transport +is_a: MONDO:0045015 ! carbohydrate transport disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:1904659 ! glucose transmembrane transport +relationship: disease_has_basis_in_disruption_of GO:1904659 ! glucose transmembrane transport +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227593 +property_value: exactMatch Orphanet:79178 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E74.8 + +[Term] +id: MONDO:0019228 +name: inborn disorder of histidine metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of histidine metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79181"} +synonym: "disorder of histidine metabolism" BROAD [Orphanet:79181] +synonym: "disturbances of histidine metabolism" EXACT [DOID:9265] +synonym: "histidine metabolism disease" RELATED [DOID:9265] +synonym: "inborn error of histidine metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn error of histidine metabolism" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn histidine metabolic process disorder" EXACT [] +synonym: "rare inborn error of histidine metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:9265 {source="MONDO:equivalentTo"} +xref: ICD10CM:E70.40 {source="MONDO:equivalentTo", source="DOID:9265"} +xref: ICD10CM:E70.8 {source="Orphanet:79181/inclusion", source="Orphanet:79181/ntbt", source="Orphanet:79181"} +xref: ICD9:270.5 {source="DOID:9265"} +xref: Orphanet:79181 {source="MONDO:equivalentTo"} +is_a: MONDO:0004736 {source="DOID:9265", source="MONDO:Entailed", source="MONDO:Redundant"} ! inherited amino acid metabolic disorder +is_a: MONDO:0004738 ! histidine metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006547 ! histidine metabolic process +property_value: exactMatch DOID:9265 +property_value: exactMatch https://icd.codes/icd10cm/E70.40 +property_value: exactMatch Orphanet:79181 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E70.8 + +[Term] +id: MONDO:0019230 +name: inborn disorder of ornithine or proline metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79185"} +synonym: "disorder of ornithine or proline metabolism" RELATED [Orphanet:79185] +xref: Orphanet:79185 {source="MONDO:equivalentTo"} +xref: UMLS:CN227595 {source="MONDO:equivalentTo"} +is_a: MONDO:0019189 {source="Orphanet:79185"} ! inborn disorder of amino acid and other organic acid metabolism +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227595 +property_value: exactMatch Orphanet:79185 + +[Term] +id: MONDO:0019235 +name: inborn disorder of phenylalanin or tyrosine metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79190"} +synonym: "disorder of phenylalanin or tyrosine metabolism" RELATED [Orphanet:79190] +xref: Orphanet:79190 {source="MONDO:equivalentTo"} +xref: UMLS:CN227599 {source="MONDO:equivalentTo"} +is_a: MONDO:0019189 {source="Orphanet:79190"} ! inborn disorder of amino acid and other organic acid metabolism +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227599 +property_value: exactMatch Orphanet:79190 + +[Term] +id: MONDO:0019236 +name: inborn disorder of purine metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of purine nucleobase metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79191"} +synonym: "disorder of purine metabolism" RELATED [Orphanet:79191] +synonym: "inborn error of purine nucleobase metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn purine nucleobase metabolic process disorder" EXACT [] +synonym: "rare inborn error of purine nucleobase metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: MedDRA:10061476 {source="Orphanet:79191", source="Orphanet:79191/e"} +xref: Orphanet:79191 {source="MONDO:equivalentTo"} +is_a: MONDO:0019254 {source="Orphanet:79191"} ! inborn disorder of purine or pyrimidine metabolism +is_a: MONDO:0037829 ! purine metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006144 ! purine nucleobase metabolic process +property_value: closeMatch http://identifiers.org/meddra/10061476 +property_value: exactMatch Orphanet:79191 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019238 +name: inborn disorder of pyrimidine metabolism +def: "ANPM" [Orphanet:79193] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79193"} +synonym: "disorder of pyrimidine metabolism" RELATED [Orphanet:79193] +synonym: "inborn error of pyrimidine nucleobase metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn pyrimidine nucleobase metabolic process disorder" EXACT [] +synonym: "pyrimidine metabolic disorder" EXACT [MONDO:0000475] +synonym: "rare inborn error of pyrimidine nucleobase metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: DOID:0050832 {source="MONDO:equivalentTo"} +xref: MedDRA:10070969 {source="Orphanet:79193", source="Orphanet:79193/e"} +xref: Orphanet:79193 {source="MONDO:equivalentTo"} +is_a: MONDO:0019254 {source="Orphanet:79193"} ! inborn disorder of purine or pyrimidine metabolism +is_a: MONDO:0037937 ! pyrimidine metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006206 ! pyrimidine nucleobase metabolic process +property_value: closeMatch http://identifiers.org/meddra/10070969 +property_value: exactMatch DOID:0050832 +property_value: exactMatch Orphanet:79193 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019239 +name: inborn disorder of serine family metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of serine family amino acid metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79194"} +synonym: "disorder of serine or glycine metabolism" RELATED [Orphanet:79194] +synonym: "inborn disorder of serine or glycine metabolism" EXACT [Orphanet:79194] +synonym: "inborn error of serine family amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn serine family amino acid metabolic process disorder" EXACT [] +synonym: "rare inborn error of serine family amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: Orphanet:79194 {source="MONDO:equivalentTo"} +xref: UMLS:CN227601 {source="MONDO:equivalentTo"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0009069 ! serine family amino acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009069 ! serine family amino acid metabolic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227601 +property_value: exactMatch Orphanet:79194 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019241 +name: inborn disorder of the gamma-glutamyl cycle +comment: Editor note: request from GO +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79196"} +synonym: "disorder of gamma-glutamyl cycle" RELATED [] +synonym: "disorder of the gamma-glutamyl cycle" RELATED [Orphanet:79196] +xref: ICD10CM:E72.8 {source="Orphanet:79196/inclusion", source="Orphanet:79196", source="Orphanet:79196/ntbt"} +xref: Orphanet:79196 {source="MONDO:equivalentTo"} +xref: SCTID:9128006 {source="MONDO:equivalentTo"} +xref: UMLS:C0268517 {source="MONDO:equivalentTo", source="Orphanet:79196", source="Orphanet:79196/e"} +is_a: MONDO:0019189 {source="Orphanet:79196"} ! inborn disorder of amino acid and other organic acid metabolism +property_value: exactMatch http://identifiers.org/snomedct/9128006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268517 +property_value: exactMatch Orphanet:79196 +property_value: narrowMatch https://icd.codes/icd10cm/E72.8 + +[Term] +id: MONDO:0019242 +name: inborn disorder of branched-chain amino acid metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of branched-chain amino acid metabolic process." [MONDO:patterns/inborn_metabolic] +comment: Editor note: consider parent for non-inborn form +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79197"} +synonym: "branched chain amino acid metabolism disorder" RELATED [] +synonym: "disorder of branched chain amino acid metabolism" RELATED [] +synonym: "disorder of branched-chain amino acid metabolism" EXACT [Orphanet:79197] +synonym: "inborn branched-chain amino acid metabolic process disorder" EXACT [] +synonym: "inborn error of branched-chain amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "rare inborn error of branched-chain amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD10CM:E71.0 {source="Orphanet:79197/specific", source="Orphanet:79197", source="Orphanet:79197/btnt"} +xref: ICD10CM:E71.1 {source="Orphanet:79197/specific", source="Orphanet:79197", source="Orphanet:79197/btnt"} +xref: ICD10CM:E71.2 {source="Orphanet:79197/specific", source="Orphanet:79197", source="Orphanet:79197/btnt"} +xref: Orphanet:79197 {source="MONDO:equivalentTo"} +xref: SCTID:116020001 {source="MONDO:equivalentTo"} +xref: UMLS:C0342712 {source="MONDO:equivalentTo", source="Orphanet:79197", source="Orphanet:79197/e"} +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0009081 ! branched-chain amino acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009081 ! branched-chain amino acid metabolic process +property_value: broadMatch https://icd.codes/icd10cm/E71.1 +property_value: broadMatch https://icd.codes/icd10cm/E71.2 +property_value: exactMatch http://identifiers.org/snomedct/116020001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342712 +property_value: exactMatch Orphanet:79197 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019243 +name: inborn disorder of energy metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of generation of precursor metabolites and energy." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79200"} +synonym: "disorder of energy metabolism" RELATED [Orphanet:79200] +synonym: "inborn error of generation of precursor metabolites and energy" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn generation of precursor metabolites and energy disorder" EXACT [] +synonym: "rare inborn error of generation of precursor metabolites and energy" EXACT [MONDO:patterns/inborn_metabolic] +xref: Orphanet:79200 {source="MONDO:equivalentTo"} +xref: UMLS:CN227604 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 {source="MONDO:Redundant", source="Orphanet:79200"} ! inborn errors of metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006091 ! generation of precursor metabolites and energy +relationship: disease_has_basis_in_disruption_of GO:0006091 ! generation of precursor metabolites and energy +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227604 +property_value: exactMatch Orphanet:79200 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019254 +name: inborn disorder of purine or pyrimidine metabolism +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79224"} +synonym: "disorder of purine or pyrimidine metabolism" RELATED [Orphanet:79224] +synonym: "inborn errors of purine-pyrimidine metabolism" EXACT [DOID:653] +synonym: "inborn purine-pyrimidine metabolic disorder" EXACT [MONDO:0003914] +synonym: "purine-pyrimidine metabolic disorder" RELATED [DOID:653] +xref: DOID:653 {source="MONDO:equivalentTo"} +xref: ICD10CM:E79.0 {source="Orphanet:79224/specific", source="Orphanet:79224/btnt", source="Orphanet:79224"} +xref: ICD10CM:E79.1 {source="Orphanet:79224/specific", source="Orphanet:79224/btnt", source="Orphanet:79224"} +xref: ICD10CM:E79.8 {source="Orphanet:79224/specific", source="Orphanet:79224/btnt", source="DOID:653", source="Orphanet:79224"} +xref: ICD10CM:E79.9 {source="Orphanet:79224/specific", source="Orphanet:79224/btnt", source="Orphanet:79224"} +xref: ICD9:277.2 {source="DOID:653"} +xref: MedDRA:10037546 {source="Orphanet:79224/e", source="Orphanet:79224"} +xref: MESH:D011686 {source="Orphanet:79224/e", source="MONDO:equivalentTo", source="Orphanet:79224"} +xref: Orphanet:79224 {source="MONDO:equivalentTo"} +xref: UMLS:C0034139 {source="Orphanet:79224/e", source="MONDO:equivalentTo", source="Orphanet:79224"} +is_a: MONDO:0019052 {source="DOID:653", source="MESH:D011686", source="MONDO:Redundant", source="Orphanet:79224"} ! inborn errors of metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_disrupts GO:0009117 ! nucleotide metabolic process +relationship: disease_disrupts GO:0009117 ! nucleotide metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009117 ! nucleotide metabolic process +property_value: broadMatch https://icd.codes/icd10cm/E79.0 +property_value: broadMatch https://icd.codes/icd10cm/E79.8 +property_value: broadMatch https://icd.codes/icd10cm/E79.9 +property_value: closeMatch http://identifiers.org/meddra/10037546 +property_value: exactMatch DOID:653 +property_value: exactMatch http://identifiers.org/mesh/D011686 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034139 +property_value: exactMatch Orphanet:79224 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0019256 +name: sterol metabolism disorder +def: "An acquired metabolic disease that is has its basis in the disruption of sterol metabolic process." [MONDO:patterns/inborn_metabolic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79226"} +synonym: "inborn error of sterol metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn sterol metabolic process disorder" EXACT [] +synonym: "rare inborn error of sterol metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: Orphanet:79226 {source="MONDO:equivalentTo"} +xref: UMLS:CN227607 {source="MONDO:equivalentTo"} +is_a: MONDO:0002525 {source="MONDO:Redundant", source="Orphanet:79226"} ! inherited lipid metabolism disorder +is_a: MONDO:0045012 ! steroid metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0016125 ! sterol metabolic process +relationship: disease_has_basis_in_disruption_of GO:0016125 ! sterol metabolic process +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227607 +property_value: exactMatch Orphanet:79226 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0019293 +name: skin vascular disease +def: "A disease that involves the superficial vasculature." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79379"} +synonym: "disorder of blood vessels affecting skin" RELATED [] +synonym: "skin vascular disorder" EXACT [NCIT:C35254] +synonym: "superficial vasculature disease" EXACT [MONDO:patterns/location] +synonym: "vascular disease of the skin" EXACT [] +synonym: "vascular disorder of skin" RELATED [] +synonym: "vascular disorders of skin" RELATED [] +synonym: "vascular skin disease" EXACT [MONDO:0004814] +synonym: "vasculature skin disease" EXACT [MONDO:patterns/location] +xref: DOID:9540 {source="MONDO:equivalentTo"} +xref: ICD9:709.1 {source="DOID:9540"} +xref: MedDRA:10062171 {source="Orphanet:79379/e", source="Orphanet:79379"} +xref: MESH:D017445 {source="Orphanet:79379/e", source="MONDO:equivalentTo", source="DOID:9540", source="Orphanet:79379"} +xref: NCIT:C35254 {source="MONDO:equivalentTo", source="DOID:9540"} +xref: Orphanet:79379 {source="MONDO:equivalentTo"} +xref: SCTID:11263005 {source="MONDO:equivalentTo", source="DOID:9540"} +xref: UMLS:C0162819 {source="Orphanet:79379/e", source="MONDO:equivalentTo", source="DOID:9540", source="Orphanet:79379"} +is_a: MONDO:0005093 {source="DOID:9540", source="MESH:D017445", source="MONDO:Redundant", source="NCIT:C35254"} ! skin disorder +is_a: MONDO:0005385 {source="MONDO:Redundant", source="NCIT:C35254"} ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0005093 ! skin disorder +intersection_of: disease_has_location UBERON:0002049 ! vasculature +intersection_of: disease_has_location UBERON:0035549 ! vasculature of integument +relationship: disease_has_location UBERON:0035549 ! vasculature of integument +property_value: closeMatch http://identifiers.org/meddra/10062171 +property_value: exactMatch DOID:9540 +property_value: exactMatch http://identifiers.org/mesh/D017445 +property_value: exactMatch http://identifiers.org/snomedct/11263005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0162819 +property_value: exactMatch NCIT:C35254 +property_value: exactMatch Orphanet:79379 +property_value: excluded_subClassOf MONDO:0019291 {source="Orphanet:79379"} + +[Term] +id: MONDO:0019296 +name: subcutaneous tissue disorder +def: "A disease involving the superficial fascia." [MONDO:patterns/location_top] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79382"} +synonym: "disease of superficial fascia" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of superficial fascia" EXACT [] +synonym: "disorder of superficial fascia" EXACT [MONDO:patterns/location_top] +synonym: "superficial fascia disease" EXACT [MONDO:patterns/location] +synonym: "superficial fascia disease or disorder" EXACT [MONDO:patterns/location] +xref: Orphanet:79382 {source="MONDO:equivalentTo"} +xref: UMLS:C1290008 {source="MONDO:equivalentTo", source="Orphanet:79382", source="Orphanet:79382/e"} +is_a: MONDO:0002051 ! integumentary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0011818 ! superficial fascia +relationship: disease_has_location UBERON:0011818 ! superficial fascia +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290008 +property_value: exactMatch Orphanet:79382 +property_value: excluded_subClassOf MONDO:0019043 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0019496 +name: neuroendocrine neoplasm +def: "Endocrine tumours, also referred to as neuroendocrine tumours (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumours may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumours or for a clinical syndrome caused by abnormal hormone secretion)." [Orphanet:877] +comment: Editor note: TODO design pattern, often NCIT uses 'neuroendocrine tumor' for particular grading with 'neuroendocrine neoplasm' as the superclass +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:877"} +synonym: "APUDoma" EXACT [Orphanet:877] +synonym: "neuroendocrine neoplasm" EXACT [DOID:169, NCIT:C3809] +synonym: "neuroendocrine tumor" EXACT [NCIT:C3809] +xref: DOID:169 {source="MONDO:equivalentTo"} +xref: EFO:1001901 {source="MONDO:equivalentTo"} +xref: ICD9:209 {source="DOID:169"} +xref: ICD9:209-209.99 {source="DOID:169"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D018358 {source="MONDO:equivalentTo", source="DOID:169"} +xref: NCIT:C3809 {source="MONDO:equivalentTo", source="DOID:169"} +xref: Orphanet:877 {source="MONDO:equivalentTo"} +xref: SCTID:255046005 {source="MONDO:equivalentTo", source="DOID:169"} +xref: UMLS:C0003650 {source="Orphanet:877", source="MONDO:equivalentTo"} +xref: UMLS:C0206754 {source="Orphanet:877", source="MONDO:equivalentTo", source="NCIT:C3809", source="DOID:169"} +xref: UMLS:CN206284 {source="MONDO:equivalentTo"} +is_a: MONDO:0002082 {source="EFO:1001901", source="MONDO:Redundant", source="NCIT:C3809", source="Orphanet:877"} ! endocrine gland neoplasm +relationship: disease_has_feature HP:0002027 {source="MONDO:Wikidata"} ! Abdominal pain +relationship: disease_has_feature MONDO:0001517 {source="MONDO:Wikidata"} ! dysentery +property_value: exactMatch DOID:169 +property_value: exactMatch http://identifiers.org/mesh/D018358 +property_value: exactMatch http://identifiers.org/snomedct/255046005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0003650 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206754 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206284 +property_value: exactMatch NCIT:C3809 +property_value: exactMatch Orphanet:877 + +[Term] +id: MONDO:0019512 +name: congenital heart malformation +def: "A disease that has its basis in the disruption of heart development." [MONDO:patterns/basis_in_disruption_of_process] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:88991"} +synonym: "congenital heart malformation" EXACT [MONDO:0005472] +synonym: "congenital non-syndromic heart malformation" RELATED [Orphanet:88991] +synonym: "disorder of heart development" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "heart development disease" EXACT [MONDO:design_pattern] +synonym: "rare congenital non-syndromic heart malformation" RELATED [Orphanet:88991] +xref: EFO:0005269 {source="MONDO:equivalentTo"} +xref: Orphanet:88991 {source="MONDO:equivalentTo"} +is_a: MONDO:0024239 ! congenital anomaly of cardiovascular system +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0007507 ! heart development +relationship: disease_has_basis_in_disruption_of GO:0007507 ! heart development +relationship: has_modifier MONDO:0021136 {source="MONDO:0020003"} ! rare +property_value: exactMatch Orphanet:88991 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0019722 +name: glomerular disorder +def: "A disease involving the renal glomerulus." [MONDO:patterns/location_top] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93548"} +synonym: "disease of renal glomerulus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of renal glomerulus" EXACT [] +synonym: "disorder of renal glomerulus" EXACT [MONDO:patterns/location_top] +synonym: "glomerulopathies" RELATED [GTR:AN0966176] +synonym: "glomerulopathy" EXACT [MONDO:patterns/location] +synonym: "renal glomerulus disease" EXACT [MONDO:patterns/location] +synonym: "renal glomerulus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: GTR:AN0966176 {source="UMLS:CN580795"} +xref: ICD10CM:N00-N08 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: NCIT:C120887 {source="MONDO:equivalentTo"} +xref: Orphanet:93548 {source="MONDO:equivalentTo"} +xref: SCTID:197679002 {source="MONDO:equivalentTo"} +xref: UMLS:CN580795 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="MONDO:Redundant", source="NCIT:C120887/inferred", source="Orphanet:93548"} ! kidney disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000074 ! renal glomerulus +relationship: disease_has_location UBERON:0000074 ! renal glomerulus +relationship: has_modifier MONDO:0021136 {source="MONDO:0019750"} ! rare +property_value: exactMatch http://identifiers.org/snomedct/197679002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN580795 +property_value: exactMatch https://icd.codes/icd10cm/N00-N08 +property_value: exactMatch NCIT:C120887 +property_value: exactMatch Orphanet:93548 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0019723 +name: disease of glomerular basement membrane +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93550"} +synonym: "basement membrane disease" BROAD [Orphanet:93550] +xref: Orphanet:93550 {source="MONDO:equivalentTo"} +xref: UMLS:CN206630 {source="MONDO:equivalentTo"} +is_a: MONDO:0019722 {source="MONDO:Redundant", source="Orphanet:93550"} ! glomerular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location GO:0005604 ! basement membrane +intersection_of: disease_has_location UBERON:0005777 ! glomerular basement membrane +relationship: disease_has_location GO:0005604 ! basement membrane +relationship: disease_has_location UBERON:0005777 ! glomerular basement membrane +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206630 +property_value: exactMatch Orphanet:93550 + +[Term] +id: MONDO:0019724 +name: secondary glomerular disease +def: "Secondary glomerular diseases are conditions with glomerular pathology in which an underlying cause can be established." [https://doi.org/10.1016/j.mpmed.2007.06.008] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93551"} +xref: Orphanet:93551 {source="MONDO:equivalentTo"} +xref: UMLS:CN206631 {source="MONDO:equivalentTo"} +is_a: MONDO:0019722 {source="Orphanet:93551"} ! glomerular disorder +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206631 +property_value: exactMatch Orphanet:93551 + +[Term] +id: MONDO:0019725 +name: pediatric systemic lupus erythematosus +subset: ordo_disease {source="Orphanet:93552"} +synonym: "SLE, pediatric onset" EXACT [Orphanet:93552] +xref: ICD10CM:M32.0 {source="Orphanet:93552/ntbt", source="Orphanet:93552"} +xref: ICD10CM:M32.1 {source="Orphanet:93552/ntbt", source="Orphanet:93552"} +xref: ICD10CM:M32.8 {source="Orphanet:93552/ntbt", source="Orphanet:93552"} +xref: ICD10CM:M32.9 {source="Orphanet:93552/ntbt", source="Orphanet:93552"} +xref: Orphanet:93552 {source="MONDO:equivalentTo"} +is_a: MONDO:0007915 {source="https://orcid.org/0000-0001-5208-3432"} ! systemic lupus erythematosus +intersection_of: MONDO:0007915 ! systemic lupus erythematosus +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch Orphanet:93552 +property_value: excluded_subClassOf MONDO:0015657 {source="Orphanet:93552"} +property_value: excluded_subClassOf MONDO:0017021 {source="Orphanet:93552"} +property_value: excluded_subClassOf MONDO:0019724 {source="Orphanet:93552"} +property_value: excluded_subClassOf MONDO:0019737 {source="Orphanet:93552"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml +property_value: narrowMatch https://icd.codes/icd10cm/M32.0 +property_value: narrowMatch https://icd.codes/icd10cm/M32.1 +property_value: narrowMatch https://icd.codes/icd10cm/M32.8 +property_value: narrowMatch https://icd.codes/icd10cm/M32.9 + +[Term] +id: MONDO:0019737 +name: thrombotic microangiopathy +def: "The syndromes of microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ impairment, due to platelet aggregation in the microcirculation." [NCIT:C62605] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93573"} +xref: GARD:0012465 {source="MONDO:equivalentTo"} +xref: ICD10CM:M31.1 {source="MONDO:equivalentTo"} +xref: ICD9:446.6 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10043645 {source="Orphanet:93573", source="Orphanet:93573/e"} +xref: MESH:D057049 {source="Orphanet:93573", source="MONDO:equivalentTo", source="Orphanet:93573/e"} +xref: NCIT:C62605 {source="MONDO:equivalentTo"} +xref: Orphanet:93573 {source="MONDO:equivalentTo"} +xref: SCTID:126729006 {source="MONDO:equivalentTo"} +xref: UMLS:C2717961 {source="Orphanet:93573", source="NCIT:C62605", source="MONDO:equivalentTo", source="Orphanet:93573/e"} +is_a: MONDO:0001531 {source="MONDO:Redundant", source="NCIT:C62605"} ! blood coagulation disease +is_a: MONDO:0005240 {source="Orphanet:93573"} ! kidney disorder +property_value: closeMatch http://identifiers.org/meddra/10043645 +property_value: exactMatch http://identifiers.org/mesh/D057049 +property_value: exactMatch http://identifiers.org/snomedct/126729006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2717961 +property_value: exactMatch https://icd.codes/icd10cm/M31.1 +property_value: exactMatch NCIT:C62605 +property_value: exactMatch Orphanet:93573 + +[Term] +id: MONDO:0019743 +name: nephropathy secondary to a storage or other metabolic disease +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93593"} +xref: Orphanet:93593 {source="MONDO:equivalentTo"} +xref: UMLS:CN206659 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="Orphanet:93593"} ! kidney disorder +relationship: has_modifier MONDO:0021136 {source="MONDO:0020030"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206659 +property_value: exactMatch Orphanet:93593 + +[Term] +id: MONDO:0019755 +name: developmental defect during embryogenesis +def: "A disease that has its basis in the disruption of embryonic morphogenesis." [MONDO:design_pattern] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:93890"} +synonym: "congenital malformation syndrome" EXACT [] +synonym: "developmental defect during embryogenesis" EXACT [] +synonym: "disorder of embryonic morphogenesis" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "embryonic morphogenesis disease" EXACT [MONDO:design_pattern] +synonym: "malformation syndrome" EXACT [Orphanet:93890] +synonym: "rare developmental defect during embryogenesis" EXACT [Orphanet:93890] +xref: ICD9:759.7 +xref: NCIT:C99267 {source="MONDO:equivalentTo"} +xref: Orphanet:93890 {source="MONDO:equivalentTo"} +xref: SCTID:400038003 {source="MONDO:equivalentTo"} +xref: UMLS:C1302790 {source="MONDO:equivalentTo"} +xref: UMLS:CN206687 {source="MONDO:equivalentTo"} +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0048598 ! embryonic morphogenesis +relationship: disease_has_basis_in_disruption_of GO:0048598 ! embryonic morphogenesis +property_value: exactMatch http://identifiers.org/snomedct/400038003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1302790 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206687 +property_value: exactMatch NCIT:C99267 +property_value: exactMatch Orphanet:93890 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0019781 +name: astrocytoma (excluding glioblastoma) +def: "A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma." [https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23, NCIT:C60781] +comment: This class denotes astrocytomas proper which excludes GBM. See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23 +synonym: "astrocytoma" EXACT AMBIGUOUS [https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23, NCIT:C60781] +xref: ICDO:9400/3 {source="NCIT:C60781"} +xref: MESH:D001254 {source="MONDO:equivalentTo"} +xref: NCIT:C60781 {source="MONDO:equivalentTo"} +xref: ONCOTREE:ASTR {source="MONDO:equivalentTo"} +xref: SCTID:147101000119108 {source="MONDO:equivalentTo"} +xref: UMLS:C0004114 {source="DOID:3069", source="Orphanet:94/e", source="MONDO:equivalentTo", source="Orphanet:94", source="NCIT:C60781"} +is_a: MONDO:0021636 {source="NCIT:C60781"} ! astrocytic tumor +relationship: disease_has_location CL:0000127 ! astrocyte +property_value: exactMatch http://identifiers.org/mesh/D001254 +property_value: exactMatch http://identifiers.org/snomedct/147101000119108 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004114 +property_value: exactMatch NCIT:C60781 + +[Term] +id: MONDO:0019792 +name: autosomal dominant cerebellar ataxia type I +def: "Autosomal dominant cerebellar ataxia (ADCA) type I is a group of spinocerebellar ataxias (SCAs) characterized by ataxia with other neurological signs, including oculomotor disturbances, cognitive deficits, pyramidal and extrapyramidal dysfunction, bulbar, spinal and peripheral nervous system involvement." [Orphanet:94145] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:94145"} +synonym: "ADCA1" EXACT ABBREVIATION [Orphanet:94145] +synonym: "ADCAI" EXACT ABBREVIATION [Orphanet:94145] +synonym: "autosomal dominant cerebellar ataxia type 1" EXACT [Orphanet:94145] +synonym: "cerebellar plus syndrome" EXACT [Orphanet:94145] +xref: ICD10CM:G11.8 {source="Orphanet:94145", source="Orphanet:94145/attributed", source="Orphanet:94145/ntbt"} +xref: Orphanet:94145 {source="MONDO:equivalentTo"} +xref: UMLS:CN206744 {source="MONDO:equivalentTo"} +is_a: MONDO:0020380 {source="Orphanet:94145"} ! autosomal dominant cerebellar ataxia +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206744 +property_value: exactMatch Orphanet:94145 +property_value: narrowMatch https://icd.codes/icd10cm/G11.8 + +[Term] +id: MONDO:0019824 +name: non-acquired pituitary hormone deficiency +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:95488"} +xref: ICD10CM:E23.0 {source="Orphanet:95488/attributed", source="Orphanet:95488/ntbt", source="MONDO:relatedTo", source="Orphanet:95488"} +xref: Orphanet:95488 {source="MONDO:equivalentTo"} +is_a: MONDO:0015127 {source="Orphanet:95488"} ! pituitary deficiency +is_a: MONDO:0015514 {source="Orphanet:95488"} ! genetic endocrine growth disease +property_value: exactMatch Orphanet:95488 + +[Term] +id: MONDO:0019832 +name: acquired pituitary hormone deficiency +def: "An instance of hypopituitarism that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +comment: Editor note: check this +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:95502"} +synonym: "acquired hypopituitarism" EXACT [MONDO:patterns/acquired] +xref: ICD10CM:E23.0 {source="MONDO:relatedTo", source="Orphanet:95502", source="Orphanet:95502/ntbt"} +xref: Orphanet:95502 {source="MONDO:equivalentTo"} +is_a: MONDO:0005152 ! hypopituitarism +is_a: MONDO:0015127 {source="MONDO:Redundant", source="Orphanet:95502"} ! pituitary deficiency +intersection_of: MONDO:0005152 ! hypopituitarism +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch Orphanet:95502 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml + +[Term] +id: MONDO:0019833 +name: pituitary hormone deficiency from tumoral origin +comment: Editor note: Orphanet classifies many things under here that violate the true-path rule; for example menigioma. Obsolescence reason: out of scope. MONDO:excludeGroupingClass and MONDO:excludeCausingAgents. Term to consider: MONDO:0015127 pituitary deficiency +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:95503"} +xref: Orphanet:95503 {source="MONDO:equivalentTo"} +xref: UMLS:CN206780 {source="MONDO:equivalentTo"} +is_a: MONDO:0019832 {source="Orphanet:95503"} ! acquired pituitary hormone deficiency +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206780 +property_value: exactMatch Orphanet:95503 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0019835 +name: primary hypophysitis +def: "Immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease)." [MESH:D000069281] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:95506"} +synonym: "autoimmune hypophysitis" EXACT [Orphanet:95506] +synonym: "lymphocytic hypophysitis" EXACT [NCIT:C132055] +xref: ICD10CM:E23.6 {source="Orphanet:95506", source="Orphanet:95506/ntbt"} +xref: ICD9:253.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:279.49 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D000069281 {source="MONDO:equivalentTo"} +xref: NCIT:C132055 {source="MONDO:equivalentTo"} +xref: Orphanet:95506 {source="MONDO:equivalentTo"} +xref: SCTID:237706000 {source="MONDO:equivalentTo"} +is_a: MONDO:0000568 ! autoimmune disorder of central nervous system +is_a: MONDO:0000569 {source="MONDO:Entailed"} ! autoimmune disorder of endocrine system +is_a: MONDO:0019832 {source="Orphanet:95506"} ! acquired pituitary hormone deficiency +is_a: MONDO:0021156 {source="MESH:D000069281", source="MONDO:Redundant"} ! hypophysitis +property_value: exactMatch http://identifiers.org/mesh/D000069281 +property_value: exactMatch http://identifiers.org/snomedct/237706000 +property_value: exactMatch NCIT:C132055 +property_value: exactMatch Orphanet:95506 +property_value: narrowMatch https://icd.codes/icd10cm/E23.6 + +[Term] +id: MONDO:0019838 +name: adenohypophysitis +def: "An autoimmune disease of the pituitary gland which can present with varying degrees of pituitary hormonal impairment and/or with symptoms related to pituitary enlargement. It predominantly affects young women in pregnancy or the peripartum period." [PMID:21592417] +subset: ordo_disease {source="Orphanet:95512"} +synonym: "adenohypophysis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "anterior pituitary hypophysitis" EXACT [Orphanet:95512] +synonym: "inflammation of adenohypophysis" EXACT [] +synonym: "lymphocytic adenohypophysitis" EXACT [PMID:21592417] +xref: ICD10CM:E23.6 {source="Orphanet:95512", source="Orphanet:95512/ntbt"} +xref: Orphanet:95512 {source="MONDO:equivalentTo"} +is_a: MONDO:0019835 {source="Orphanet:95512"} ! primary hypophysitis +is_a: MONDO:0024468 ! anterior pituitary gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002196 ! adenohypophysis +relationship: disease_has_inflammation_site UBERON:0002196 ! adenohypophysis +property_value: exactMatch Orphanet:95512 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E23.6 + +[Term] +id: MONDO:0019851 +name: acquired primary ovarian failure +def: "An instance of primary ovarian failure that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:95709"} +synonym: "acquired premature ovarian failure" RELATED [Orphanet:95709] +synonym: "acquired primary ovarian failure" EXACT [MONDO:patterns/acquired] +xref: ICD10CM:E28.8 {source="Orphanet:95709", source="Orphanet:95709/attributed", source="Orphanet:95709/ntbt"} +xref: Orphanet:95709 {source="MONDO:equivalentTo"} +xref: SCTID:717954003 {source="MONDO:equivalentTo"} +xref: UMLS:C4303540 {source="MONDO:equivalentTo"} +is_a: MONDO:0005387 ! primary ovarian failure +is_a: MONDO:0015860 {source="MONDO:Redundant", source="Orphanet:95709"} ! anomaly of puberty or/and menstrual cycle +intersection_of: MONDO:0005387 ! primary ovarian failure +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://identifiers.org/snomedct/717954003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4303540 +property_value: exactMatch Orphanet:95709 +property_value: excluded_subClassOf MONDO:0015514 {source="Orphanet:95709"} +property_value: excluded_subClassOf MONDO:0019590 {source="Orphanet:95709"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml +property_value: narrowMatch https://icd.codes/icd10cm/E28.8 + +[Term] +id: MONDO:0019852 +name: inherited primary ovarian failure +def: "An instance of primary ovarian failure that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:95710"} +synonym: "hereditary primary ovarian failure" EXACT [MONDO:patterns/hereditary] +synonym: "inherited premature ovarian failure" EXACT [OMIMPS:311360] +synonym: "non-acquired premature ovarian failure" RELATED [] +xref: ICD10CM:E28.3 {source="MONDO:relatedTo", source="Orphanet:95710", source="Orphanet:95710/attributed", source="Orphanet:95710/ntbt"} +xref: OMIMPS:311360 {source="MONDO:equivalentTo"} +xref: Orphanet:95710 {source="MONDO:equivalentTo"} +is_a: MONDO:0005387 ! primary ovarian failure +is_a: MONDO:0015514 {source="Orphanet:95710"} ! genetic endocrine growth disease +is_a: MONDO:0016072 {source="MONDO:Redundant", source="Orphanet:95710"} ! anomaly of puberty or/and menstrual cycle of genetic origin +intersection_of: MONDO:0005387 ! primary ovarian failure +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch https://omim.org/phenotypicSeries/PS311360 +property_value: exactMatch Orphanet:95710 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0019927 +name: growth hormone-producing pituitary gland neoplasm +def: "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone." [NCIT:C7911] +synonym: "growth hormone producing neoplasm of pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone producing neoplasm of pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone producing neoplasm of the pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone producing neoplasm of the pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone producing pituitary gland neoplasm" EXACT [NCIT:C7911] +synonym: "growth hormone producing pituitary gland tumor" EXACT [NCIT:C7911] +synonym: "growth hormone producing pituitary neoplasm" EXACT [NCIT:C7911] +synonym: "growth hormone producing pituitary tumor" EXACT [NCIT:C7911] +synonym: "growth hormone producing tumor" EXACT [NCIT:C7911] +synonym: "growth hormone producing tumor of pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone producing tumor of pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone producing tumor of the pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone producing tumor of the pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone secreting neoplasm of pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone secreting neoplasm of pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone secreting neoplasm of the pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone secreting neoplasm of the pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone secreting pituitary gland neoplasm" EXACT [NCIT:C7911] +synonym: "growth hormone secreting pituitary gland tumor" EXACT [NCIT:C7911] +synonym: "growth hormone secreting pituitary neoplasm" EXACT [NCIT:C7911] +synonym: "growth hormone secreting pituitary tumor" EXACT [NCIT:C7911] +synonym: "growth hormone secreting tumor of pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone secreting tumor of pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone secreting tumor of the pituitary" EXACT [NCIT:C7911] +synonym: "growth hormone secreting tumor of the pituitary gland" EXACT [NCIT:C7911] +synonym: "growth hormone-producing pituitary gland neoplasm" EXACT [NCIT:C7911] +synonym: "Growth hormone-producing pituitary gland tumor" EXACT [NCIT:C7911] +synonym: "pituitary gland somatotropinoma" EXACT [NCIT:C7911] +synonym: "pituitary somatotropinoma" EXACT [NCIT:C7911] +synonym: "somatotroph neoplasm" EXACT [NCIT:C7911] +synonym: "somatotroph tumor" EXACT [NCIT:C7911] +synonym: "somatotropinoma" EXACT [NCIT:C7911, Orphanet:96256] +synonym: "somatotropinoma of pituitary" EXACT [NCIT:C7911] +synonym: "somatotropinoma of pituitary gland" EXACT [NCIT:C7911] +synonym: "somatotropinoma of the pituitary" EXACT [NCIT:C7911] +synonym: "somatotropinoma of the pituitary gland" EXACT [NCIT:C7911] +xref: NCIT:C7911 {source="MONDO:equivalentTo"} +xref: UMLS:C0278864 {source="MONDO:equivalentTo", source="NCIT:C7911"} +is_a: MONDO:0005626 ! epithelial neoplasm +is_a: MONDO:0017611 ! pituitary tumor +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +intersection_of: realized_in GO:0030252 ! growth hormone secretion +relationship: disease_arises_from_structure CL:0002312 {source="NCIT:C7911"} ! somatotroph +relationship: realized_in GO:0030252 ! growth hormone secretion +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278864 +property_value: exactMatch NCIT:C7911 + +[Term] +id: MONDO:0019954 +name: pancreatic neuroendocrine tumor +def: "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)." [Orphanet:97253] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:97253"} +synonym: "islet cell tumor" EXACT [NCIT:C27720] +synonym: "islet cell tumors - pancreas" EXACT [NCIT:C27720] +synonym: "islet cell tumors of the pancreas" EXACT [NCIT:C27720] +synonym: "neuroendocrine tumor of pancreas" RELATED [Orphanet:97253] +synonym: "pancreatic endocrine tumor" RELATED [GARD:0013034] +synonym: "pancreatic NET" EXACT [NCIT:C27720] +synonym: "pancreatic neuroendocrine tumor" EXACT [MONDO:0006048, NCIT:C27720] +synonym: "PANET" RELATED ABBREVIATION [ONCOTREE:PANET] +synonym: "well differentiated pancreatic endocrine neoplasm" EXACT [NCIT:C27720] +synonym: "well differentiated pancreatic endocrine tumor" EXACT [NCIT:C27720] +synonym: "well-differentiated NEN of pancreas" EXACT [Orphanet:97253] +synonym: "well-differentiated neuroendocrine neoplasm of pancreas" EXACT [Orphanet:97253] +synonym: "well-differentiated pancreatic NEN" EXACT [Orphanet:97253] +synonym: "well-differentiated pancreatic neuroendocrine neoplasm" EXACT [Orphanet:97253] +xref: EFO:1000045 {source="MONDO:equivalentTo"} +xref: GARD:0013034 {source="MONDO:equivalentTo"} +xref: ICD10CM:E16.8 {source="Orphanet:97253/ntbt", source="Orphanet:97253"} +xref: ICDO:8150/1 {source="NCIT:C27720"} +xref: NCIT:C27720 {source="EFO:1000045", source="MONDO:equivalentTo"} +xref: ONCOTREE:PANET {source="MONDO:equivalentTo"} +xref: Orphanet:97253 {source="MONDO:equivalentTo"} +is_a: MONDO:0000386 {source="NCIT:C27720"} ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0005815 {source="NCIT:C27720", source="Orphanet:97253"} ! pancreatic neuroendocrine neoplasm +property_value: exactMatch NCIT:C27720 +property_value: exactMatch Orphanet:97253 +property_value: narrowMatch https://icd.codes/icd10cm/E16.8 + +[Term] +id: MONDO:0019956 +name: encephalitis +def: "An acute inflammatory process affecting the brain parenchyma. Causes include viral infections and less frequently bacterial infections, toxins, and immune-mediated processes." [NCIT:C26760] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:97275"} +synonym: "brain inflammation" BROAD [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:9588 {source="MONDO:equivalentTo"} +xref: ICD10CM:A85 {source="MONDO:equivalentTo"} +xref: ICD9:323.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:323.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:323.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10014581 {source="Orphanet:97275/e", source="Orphanet:97275"} +xref: MESH:D004660 {source="Orphanet:97275/e", source="MONDO:equivalentTo", source="DOID:9588", source="Orphanet:97275"} +xref: NCIT:C26760 {source="MONDO:equivalentTo", source="DOID:9588"} +xref: Orphanet:97275 {source="MONDO:equivalentTo"} +xref: SCTID:45170000 {source="MONDO:equivalentTo", source="DOID:9588"} +xref: UMLS:C0014038 {source="NCIT:C26760", source="Orphanet:97275/e", source="MONDO:equivalentTo", source="DOID:9588", source="Orphanet:97275"} +is_a: MONDO:0015144 {source="MONDO:Redundant", source="Orphanet:97275"} ! brain inflammatory disease +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000955 ! brain +intersection_of: has_modifier PATO:0000389 ! acute +property_value: closeMatch http://identifiers.org/meddra/10014581 +property_value: exactMatch DOID:9588 +property_value: exactMatch http://identifiers.org/mesh/D004660 +property_value: exactMatch http://identifiers.org/snomedct/45170000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014038 +property_value: exactMatch https://icd.codes/icd10cm/A85 +property_value: exactMatch NCIT:C26760 +property_value: exactMatch Orphanet:97275 +property_value: excluded_subClassOf MONDO:0005108 {source="DOID:9588"} + +[Term] +id: MONDO:0019962 +name: thyroid lymphoma +def: "A lymphoma primarily involving the thyroid gland." [NCIT:C5265] +subset: ordo_disease {source="Orphanet:97285"} +synonym: "lymphoma of the thyroid" EXACT [NCIT:C5265] +synonym: "lymphoma of the thyroid gland" EXACT [NCIT:C5265] +synonym: "lymphoma of thyroid" EXACT [NCIT:C5265] +synonym: "lymphoma of thyroid gland" EXACT [NCIT:C5265] +synonym: "primary thyroid gland lymphoma" EXACT [NCIT:C5265] +synonym: "thyroid gland lymphoma" EXACT [MONDO:patterns/location, NCIT:C5265] +synonym: "thyroid lymphoma" EXACT [NCIT:C5265] +xref: DOID:10011 {source="MONDO:equivalentTo"} +xref: NCIT:C5265 {source="MONDO:equivalentTo", source="DOID:10011"} +xref: Orphanet:97285 {source="MONDO:equivalentTo"} +xref: UMLS:C1336753 {source="NCIT:C5265", source="MONDO:equivalentTo", source="DOID:10011"} +is_a: MONDO:0002108 {source="DOID:10011", source="NCIT:C5265"} ! thyroid cancer +is_a: MONDO:0017207 {source="Orphanet:97285"} ! primary organ-specific lymphoma +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch DOID:10011 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336753 +property_value: exactMatch NCIT:C5265 +property_value: exactMatch Orphanet:97285 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0019963 +name: bronchial endocrine tumor +def: "A neuroendocrine neoplasm that involves the bronchus." [MONDO:patterns/location] +subset: ordo_disease {source="Orphanet:97287"} +synonym: "bronchial NET" EXACT [Orphanet:97287] +synonym: "bronchial neuroendocrine tumor" RELATED [Orphanet:97287] +synonym: "bronchus NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "bronchus neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "bronchus neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "bronchus neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of bronchus" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +xref: ICD10CM:D38.1 {source="Orphanet:97287/ntbt", source="Orphanet:97287"} +xref: Orphanet:97287 {source="MONDO:equivalentTo"} +xref: UMLS:CN206886 {source="MONDO:equivalentTo"} +is_a: MONDO:0002807 ! bronchial neoplasm +is_a: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002185 ! bronchus +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206886 +property_value: exactMatch Orphanet:97287 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml +property_value: narrowMatch https://icd.codes/icd10cm/D38.1 + +[Term] +id: MONDO:0019964 +name: thymic neuroendocrine tumor +def: "Thymic endocrine tumor is a rare, malignant, primary thymic neoplasm originating from neuroendocrine cells, presenting as a mass within the anterior mediastinum. Patients typically present with nonspecific symptoms, such as chest pain, cough, shortness of breath, or in some cases, superior vena cava syndrome, although patients could be asymptomatic during the early stages or present with multiple endocrine neoplasia type I. Ectopic production of ACTH and serotonin can lead to Cushing syndrome and carcinoid sydrome, respectively." [Orphanet:97289] +subset: ordo_disease {source="Orphanet:97289"} +synonym: "neuroendocrine neoplasm of thymus" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "thymus NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "thymus neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "thymus neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "thymus neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: ICD10CM:D38.4 {source="Orphanet:97289", source="Orphanet:97289/ntbt"} +xref: ONCOTREE:TNET {source="MONDO:equivalentTo"} +xref: Orphanet:97289 {source="MONDO:equivalentTo"} +xref: UMLS:CN206887 {source="MONDO:equivalentTo"} +is_a: MONDO:0005197 {source="MONDO:Redundant", source="ONCOTREE:TNET", source="Orphanet:97289"} ! thymus neoplasm +is_a: MONDO:0019496 {source="MONDO:Redundant", source="Orphanet:97289", source="Orphanet:97289/inferred"} ! neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206887 +property_value: exactMatch Orphanet:97289 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml +property_value: narrowMatch https://icd.codes/icd10cm/D38.4 + +[Term] +id: MONDO:0020010 +name: infectious disorder of the nervous system +def: "A infectious disease that involves the nervous system." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98010"} +synonym: "nervous system infectious disease" EXACT [MONDO:patterns/location] +synonym: "nervous system infectious disorder" EXACT [NCIT:C27590] +xref: ICD9:349.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27590 {source="MONDO:equivalentTo"} +xref: Orphanet:98010 {source="MONDO:equivalentTo"} +xref: SCTID:128116006 {source="MONDO:equivalentTo"} +xref: UMLS:C0597039 {source="Orphanet:98010/e", source="MONDO:equivalentTo", source="NCIT:C27590", source="Orphanet:98010"} +is_a: MONDO:0005071 {source="Orphanet:98010"} ! nervous system disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0001016 ! nervous system +relationship: has_modifier MONDO:0021136 {source="MONDO:0020009"} ! rare +property_value: exactMatch http://identifiers.org/snomedct/128116006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0597039 +property_value: exactMatch NCIT:C27590 +property_value: exactMatch Orphanet:98010 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0020022 +name: central nervous system malformation +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98044"} +xref: ICD10CM:Q00-Q07 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: MESH:D009421 {source="MONDO:equivalentTo"} +xref: Orphanet:98044 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 {source="Orphanet:98044"} ! nervous system disorder +is_a: MONDO:0019755 {source="Orphanet:98044"} ! developmental defect during embryogenesis +relationship: has_modifier MONDO:0021136 {source="MONDO:0020009"} ! rare +property_value: exactMatch http://identifiers.org/mesh/D009421 +property_value: exactMatch https://icd.codes/icd10cm/Q00-Q07 +property_value: exactMatch Orphanet:98044 + +[Term] +id: MONDO:0020067 +name: infectious encephalitis +def: "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi." [NCIT:C79550] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98252"} +synonym: "encephalitis infection" EXACT [NCIT:C79550] +xref: ICD9:049.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:323.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D000069544 {source="MONDO:equivalentTo"} +xref: NCIT:C79550 {source="MONDO:equivalentTo"} +xref: SCTID:312215006 {source="MONDO:equivalentTo"} +is_a: MONDO:0019956 {source="MESH:D000069544", source="MONDO:Redundant", source="NCIT:C79550"} ! encephalitis +is_a: MONDO:0024619 {source="MESH:D000069544", source="MONDO:Redundant"} ! central nervous system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0019956 ! encephalitis +property_value: exactMatch http://identifiers.org/mesh/D000069544 +property_value: exactMatch http://identifiers.org/snomedct/312215006 +property_value: exactMatch NCIT:C79550 + +[Term] +id: MONDO:0020068 +name: postinfectious encephalitis +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98253"} +xref: ICD9:323.6 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MedDRA:10057235 {source="Orphanet:98253/e", source="Orphanet:98253"} +xref: Orphanet:98253 {source="MONDO:equivalentTo"} +xref: SCTID:192727001 {source="MONDO:equivalentTo"} +xref: UMLS:C0393459 {source="Orphanet:98253/e", source="MONDO:equivalentTo", source="Orphanet:98253"} +is_a: MONDO:0020067 ! infectious encephalitis +is_a: MONDO:0021669 ! post-infectious disorder +intersection_of: MONDO:0019956 ! encephalitis +intersection_of: disease_arises_from_feature MONDO:0005550 ! infectious disease +property_value: closeMatch http://identifiers.org/meddra/10057235 +property_value: exactMatch http://identifiers.org/snomedct/192727001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0393459 +property_value: exactMatch Orphanet:98253 + +[Term] +id: MONDO:0020069 +name: chronic encephalitis +def: "Chronic form of encephalitis." [MONDO:patterns/chronic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98255"} +synonym: "encephalitis, chronic" EXACT [MONDO:patterns/chronic] +xref: Orphanet:98255 {source="MONDO:equivalentTo"} +xref: UMLS:C0006109 {source="MONDO:equivalentTo"} +is_a: MONDO:0020067 ! infectious encephalitis +intersection_of: MONDO:0019956 ! encephalitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0006109 +property_value: exactMatch Orphanet:98255 + +[Term] +id: MONDO:0020072 +name: childhood-onset epilepsy syndrome +def: "A epilepsy syndrome that occurs during childhood." [MONDO:design_pattern] +comment: This type of grouping class represents an older way of classifying diseases, and represented here https://www.epilepsydiagnosis.org/index.html. +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98259"} +synonym: "childhood epilepsy syndrome" EXACT [MONDO:design_pattern] +synonym: "childhood-onset epilepsy syndrome" EXACT [] +synonym: "epilepsy syndrome of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric epilepsy syndrome" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: ICD10CM:G40.4 {source="Orphanet:98259", source="Orphanet:98259/attributed", source="Orphanet:98259/ntbt"} +xref: Orphanet:98259 {source="MONDO:equivalentTo"} +xref: UMLS:CN206976 {source="MONDO:equivalentTo"} +is_a: MONDO:0015650 {source="MONDO:Redundant", source="Orphanet:98259"} ! epilepsy syndrome +intersection_of: MONDO:0015650 ! epilepsy syndrome +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206976 +property_value: exactMatch Orphanet:98259 +property_value: narrowMatch https://icd.codes/icd10cm/G40.4 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/1640 xsd:anyURI + +[Term] +id: MONDO:0020073 +name: adolescent-onset epilepsy syndrome +comment: This type of grouping class represents an older way of classifying diseases, and represented here https://www.epilepsydiagnosis.org/index.html. +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98260"} +xref: ICD10CM:G40.4 {source="Orphanet:98260", source="Orphanet:98260/attributed", source="Orphanet:98260/ntbt"} +xref: Orphanet:98260 {source="MONDO:equivalentTo"} +xref: UMLS:CN206977 {source="MONDO:equivalentTo"} +is_a: MONDO:0015650 {source="Orphanet:98260"} ! epilepsy syndrome +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206977 +property_value: exactMatch Orphanet:98260 +property_value: narrowMatch https://icd.codes/icd10cm/G40.4 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/1640 xsd:anyURI + +[Term] +id: MONDO:0020076 +name: myeloproliferative neoplasm +def: "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)" [NCIT:C4345] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98274"} +synonym: "chronic myeloproliferative disease" EXACT [DOID:2226, NCIT:C4345] +synonym: "chronic myeloproliferative disorder" EXACT [MONDO:0005171, NCIT:C4345] +synonym: "chronic myeloproliferative disorders" RELATED [GARD:0009319] +synonym: "chronic myeloproliferative neoplasm" EXACT [NCIT:C4345] +synonym: "CMPD" EXACT ABBREVIATION [DOID:2226, NCIT:C4345] +synonym: "CMPD, U" RELATED [DOID:2226, NCIT:C27350] +synonym: "MPD" EXACT ABBREVIATION [NCIT:C4345, Orphanet:98274] +synonym: "MPN" EXACT ABBREVIATION [NCIT:C4345, ONCOTREE:MPN, Orphanet:98274] +synonym: "myeloproliferative disorder" EXACT [NCIT:C4345, Orphanet:98274] +synonym: "myeloproliferative neoplasm" EXACT [NCIT:C4345] +synonym: "myeloproliferative neoplasm, chronic" EXACT [MONDO:patterns/chronic] +synonym: "myeloproliferative neoplasms" RELATED [ONCOTREE:MPN] +synonym: "myeloproliferative tumor" EXACT [NCIT:C4345] +xref: DOID:2226 {source="MONDO:equivalentTo"} +xref: EFO:0002428 {source="MONDO:equivalentTo"} +xref: EFO:0004251 {source="DOID:4960", source="MONDO:equivalentTo"} +xref: GARD:0009319 {source="MONDO:shared-umls-xref", source="MONDO:equivalentTo"} +xref: ICD9:238.79 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:9960/3 {source="NCIT:C4345"} +xref: ICDO:9975/1 {source="NCIT:C4345"} +xref: MedDRA:10028576 {source="Orphanet:98274/e", source="Orphanet:98274"} +xref: NCIT:C103126 {source="MONDO:otherHierarchy", source="EFO:0002428"} +xref: NCIT:C4345 {source="DOID:2226", source="MONDO:equivalentTo", source="EFO:0004251"} +xref: ONCOTREE:MPN {source="MONDO:equivalentTo"} +xref: Orphanet:98274 {source="MONDO:equivalentTo"} +xref: SCTID:425333006 {source="MONDO:equivalentTo"} +xref: UMLS:C1292778 {source="Orphanet:98274/e", source="DOID:2226", source="MONDO:equivalentTo", source="NCIT:C4345", source="Orphanet:98274"} +is_a: MONDO:0005170 {source="DOID:2226", source="EFO:0002428", source="MONDO:Redundant", source="NCIT:C4345", source="ONCOTREE:MPN/inferred"} ! myeloid neoplasm +is_a: MONDO:0015756 {source="Orphanet:98274"} ! myeloid hemopathy +is_a: MONDO:0021138 {source="MONDO:Redundant", source="NCIT:C4345"} ! bone marrow cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: MONDO:0005170 ! myeloid neoplasm +intersection_of: disease_has_location UBERON:0002371 ! bone marrow +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: closeMatch http://identifiers.org/meddra/10028576 +property_value: exactMatch DOID:2226 +property_value: exactMatch http://identifiers.org/snomedct/425333006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1292778 +property_value: exactMatch NCIT:C4345 +property_value: exactMatch Orphanet:98274 +property_value: relatedMatch NCIT:C103126 + +[Term] +id: MONDO:0020082 +name: dendritic cell tumor +def: "A dendritic cell tumor develops from the cells of the immune system. This condition typically begins in the lymph system and may spread to nearby organs or distant parts of the body (metastasize). There are five subtypes of dendritic cell tumors: follicular dendritic cell tumor, interdigitating dendritic cell tumor, Langerhans' cell histiocytosis, Langerhans' cell sarcoma, and dendritic cell sarcoma not specified otherwise. The symptoms and severity of the condition depend on the subtype and location of the tumor. Treatment may include surgery, radiation therapy, and/or chemotherapy." [https://rarediseases.info.nih.gov/diseases/8317/dendritic-cell-tumor] +subset: disease_grouping +subset: gard_rare {source="GARD:0008317"} +subset: ordo_group_of_disorders {source="Orphanet:98289"} +synonym: "Dendritic cell neoplasm" RELATED [GARD:0008317] +synonym: "Dendritic cell sarcoma, NOS" NARROW [NCIT:C27260] +synonym: "Dendritic cell sarcoma, Not otherwise specified" NARROW [NCIT:C27260] +synonym: "Dendritic cell tumor, NOS" NARROW [NCIT:C27260] +synonym: "Dendritic cell tumor, Not otherwise specified" NARROW [NCIT:C27260] +xref: GARD:0008317 {source="MONDO:equivalentTo"} +xref: NCIT:C27260 {source="MONDO:directSiblingOf"} +xref: Orphanet:98289 {source="MONDO:equivalentTo"} +xref: SCTID:737223000 {source="MONDO:equivalentTo"} +xref: UMLS:CN206984 {source="MONDO:equivalentTo"} +is_a: MONDO:0006247 {source="NCIT:C27260", source="Orphanet:98289"} ! histiocytic and dendritic cell neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000451 ! dendritic cell +relationship: disease_arises_from_structure CL:0000451 ! dendritic cell +property_value: exactMatch http://identifiers.org/snomedct/737223000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN206984 +property_value: exactMatch Orphanet:98289 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/8317/dendritic-cell-tumor xsd:anyURI {source="GARD:0008317"} + +[Term] +id: MONDO:0020120 +name: skeletal muscle disorder +def: "A disease involving the skeletal muscle tissue." [MONDO:patterns/location_top] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98472"} +synonym: "disease of skeletal muscle tissue" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of skeletal muscle tissue" EXACT [] +synonym: "disorder of skeletal muscle tissue" EXACT [MONDO:patterns/location_top] +synonym: "skeletal muscle tissue disease" EXACT [MONDO:patterns/location] +synonym: "skeletal muscle tissue disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: MedDRA:10028641 {source="Orphanet:98472/e", source="Orphanet:98472"} +xref: Orphanet:98472 {source="MONDO:equivalentTo"} +xref: SCTID:75047002 {source="MONDO:equivalentTo"} +xref: UMLS:C1533847 {source="Orphanet:98472/e", source="MONDO:equivalentTo", source="Orphanet:98472"} +is_a: MONDO:0003939 ! muscle tissue disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001134 ! skeletal muscle tissue +relationship: disease_has_location UBERON:0001134 ! skeletal muscle tissue +property_value: closeMatch http://identifiers.org/meddra/10028641 +property_value: exactMatch http://identifiers.org/snomedct/75047002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1533847 +property_value: exactMatch Orphanet:98472 +property_value: excluded_subClassOf MONDO:0019056 {source="Orphanet:98472"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0020122 +name: acquired idiopathic inflammatory myopathy +def: "An umbrella term for diseases which have chronic muscle inflammation and weakness of unknown etiology. The types of idiopathic inflammatory myopathy are further defined by either clinicopathologic criteria or by the presence of certain autoantibodies." [NCIT:C116796] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98482"} +synonym: "idiopathic inflammatory myopathies" EXACT [NCIT:C116796] +synonym: "idiopathic inflammatory myopathy, familial" RELATED [GARD:0009128] +synonym: "idiopathic inflammatory myositis" EXACT [Orphanet:98482] +synonym: "IIm" EXACT [NCIT:C116796] +synonym: "IMM" EXACT ABBREVIATION [Orphanet:98482] +xref: GARD:0009128 {source="MONDO:equivalentTo"} +xref: ICD9:359.79 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:98482 {source="MONDO:equivalentTo"} +is_a: MONDO:0016105 {source="Orphanet:98482"} ! acquired skeletal muscle disease +is_a: MONDO:0600023 ! idiopathic inflammatory myopathy +is_a: MONDO:0700007 ! idiopathic disease +property_value: exactMatch Orphanet:98482 + +[Term] +id: MONDO:0020124 +name: neuromuscular junction disease +def: "Conditions characterized by impaired transmission of impulses at the neuromuscular junction. This may result from disorders that affect receptor function, pre- or postsynaptic membrane function, or acetylcholinesterase activity. The majority of diseases in this category are associated with autoimmune, toxic, or inherited conditions." [MESH:D020511] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98491"} +xref: DOID:439 {source="MONDO:equivalentTo"} +xref: ICD10CM:G70.0 {source="Orphanet:98491", source="Orphanet:98491/ntbt"} +xref: ICD10CM:G70.1 {source="Orphanet:98491", source="Orphanet:98491/ntbt"} +xref: ICD10CM:G70.2 {source="Orphanet:98491", source="Orphanet:98491/ntbt"} +xref: ICD10CM:G70.8 {source="Orphanet:98491", source="Orphanet:98491/ntbt"} +xref: ICD10CM:G70.9 {source="Orphanet:98491", source="Orphanet:98491/ntbt"} +xref: MESH:D020511 {source="DOID:439", source="MONDO:equivalentTo", source="Orphanet:98491", source="Orphanet:98491/e"} +xref: Orphanet:98491 {source="MONDO:equivalentTo"} +xref: SCTID:128213006 {source="DOID:439", source="MONDO:equivalentTo"} +xref: UMLS:C0751950 {source="DOID:439", source="MONDO:equivalentTo", source="Orphanet:98491", source="Orphanet:98491/e"} +is_a: MONDO:0019056 {source="DOID:439", source="MESH:D020511", source="Orphanet:98491"} ! neuromuscular disease +is_a: MONDO:0021017 ! synaptopathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0031594 ! neuromuscular junction +relationship: disease_has_basis_in_dysfunction_of GO:0031594 ! neuromuscular junction +property_value: exactMatch DOID:439 +property_value: exactMatch http://identifiers.org/mesh/D020511 +property_value: exactMatch http://identifiers.org/snomedct/128213006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751950 +property_value: exactMatch Orphanet:98491 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml +property_value: narrowMatch https://icd.codes/icd10cm/G70.1 +property_value: narrowMatch https://icd.codes/icd10cm/G70.2 +property_value: narrowMatch https://icd.codes/icd10cm/G70.8 +property_value: narrowMatch https://icd.codes/icd10cm/G70.9 + +[Term] +id: MONDO:0020125 +name: acquired neuromuscular junction disease +def: "An instance of neuromuscular junction disease that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98494"} +synonym: "acquired neuromuscular junction disease" EXACT [MONDO:patterns/acquired] +xref: Orphanet:98494 {source="MONDO:equivalentTo"} +xref: UMLS:CN207015 {source="MONDO:equivalentTo"} +is_a: MONDO:0020124 {source="MONDO:Redundant", source="Orphanet:98494"} ! neuromuscular junction disease +intersection_of: MONDO:0020124 ! neuromuscular junction disease +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207015 +property_value: exactMatch Orphanet:98494 + +[Term] +id: MONDO:0020127 +name: genetic peripheral neuropathy +def: "Genetic peripheral neuropathy." [] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005244 peripheral neuropathy +subset: clingen +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:98497"} +synonym: "genetic peripheral neuropathy" EXACT [MONDO:patterns/genetic] +xref: Orphanet:98497 {source="MONDO:equivalentTo"} +is_a: MONDO:0005244 {source="MONDO:Redundant", source="Orphanet:98497"} ! peripheral neuropathy +is_a: MONDO:0019117 {source="MONDO:Redundant", source="Orphanet:98497"} ! genetic nervous system disorder +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch Orphanet:98497 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0020128 +name: motor neuron disorder +def: "A disease involving the motor neuron." [MONDO:patterns/location_top] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98503"} +synonym: "anterior horn cell disease" EXACT [Orphanet:98503] +synonym: "disease of motor neuron" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of motor neuron" EXACT [] +synonym: "disorder of motor neuron" EXACT [MONDO:patterns/location_top] +synonym: "motor neuron disease" EXACT [MONDO:0005270, MONDO:patterns/location] +synonym: "motor neuron disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: DOID:231 {source="EFO:0003782", source="MONDO:equivalentTo"} +xref: EFO:0003782 {source="MONDO:equivalentTo"} +xref: ICD10CM:G12.2 {source="Orphanet:98503", source="MONDO:equivalentTo", source="DOID:231", source="Orphanet:98503/e"} +xref: ICD9:335.2 {source="EFO:0003782", source="DOID:231"} +xref: ICD9:335.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:335.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10028003 {source="Orphanet:98503", source="Orphanet:98503/e"} +xref: MESH:D016472 {source="EFO:0003782", source="Orphanet:98503", source="MONDO:equivalentTo", source="DOID:231", source="Orphanet:98503/e"} +xref: Orphanet:98503 {source="MONDO:equivalentTo"} +xref: SCTID:37340000 {source="EFO:0003782", source="MONDO:equivalentTo", source="DOID:231"} +is_a: MONDO:0005559 {source="DOID:231", source="EFO:0003782", source="https://github.com/monarch-initiative/mondo/issues/1588"} ! neurodegenerative disease +is_a: MONDO:0019056 {source="MESH:D016472", source="Orphanet:98503"} ! neuromuscular disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location CL:0000100 ! motor neuron +relationship: disease_has_location CL:0000100 ! motor neuron +property_value: closeMatch http://identifiers.org/meddra/10028003 +property_value: exactMatch DOID:231 +property_value: exactMatch http://identifiers.org/mesh/D016472 +property_value: exactMatch http://identifiers.org/snomedct/37340000 +property_value: exactMatch https://icd.codes/icd10cm/G12.2 +property_value: exactMatch Orphanet:98503 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0020129 +name: acquired motor neuron disease +def: "An instance of motor neuron disease that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98506"} +synonym: "acquired anterior horn cell disease" EXACT [Orphanet:98506] +synonym: "acquired motor neuron disease" EXACT [MONDO:patterns/acquired] +xref: Orphanet:98506 {source="MONDO:equivalentTo"} +xref: UMLS:CN207019 {source="MONDO:equivalentTo"} +is_a: MONDO:0020128 {source="MONDO:Redundant", source="Orphanet:98506"} ! motor neuron disorder +intersection_of: MONDO:0020128 ! motor neuron disorder +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207019 +property_value: exactMatch Orphanet:98506 + +[Term] +id: MONDO:0020144 +name: cerebrovascular dementia +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98549"} +synonym: "rare cerebrovascular dementia" RELATED [Orphanet:98549] +xref: Orphanet:98549 {source="MONDO:equivalentTo"} +is_a: MONDO:0001627 {source="MONDO:Redundant", source="Orphanet:98549"} ! dementia +intersection_of: MONDO:0001627 ! dementia +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0008998 ! vasculature of brain +relationship: disease_has_basis_in_dysfunction_of UBERON:0008998 ! vasculature of brain +relationship: has_modifier MONDO:0021136 {source="MONDO:0019515"} ! rare +property_value: exactMatch Orphanet:98549 + +[Term] +id: MONDO:0020145 +name: developmental defect of the eye +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98553"} +xref: Orphanet:98553 {source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="Orphanet:98553"} ! eye disorder +is_a: MONDO:0019755 {source="Orphanet:98553"} ! developmental defect during embryogenesis +intersection_of: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: disease_disrupts GO:0043010 ! camera-type eye development +relationship: disease_disrupts GO:0043010 ! camera-type eye development +relationship: has_modifier MONDO:0021136 {source="MONDO:0015107"} ! rare +property_value: exactMatch Orphanet:98553 + +[Term] +id: MONDO:0020146 +name: major induction processes eye anomaly +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98554"} +xref: Orphanet:98554 {source="MONDO:equivalentTo"} +is_a: MONDO:0020145 {source="MONDO:Redundant", source="Orphanet:98554"} ! developmental defect of the eye +intersection_of: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: disease_has_basis_in_disruption_of GO:0060235 ! lens induction in camera-type eye +relationship: disease_has_basis_in_disruption_of GO:0060235 ! lens induction in camera-type eye +property_value: exactMatch Orphanet:98554 + +[Term] +id: MONDO:0020172 +name: palpebral epidermal tumor +def: "A neoplasm (disease) that involves the skin of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98581"} +synonym: "neoplasm of skin of eyelid" EXACT [MONDO:patterns/neoplasm] +synonym: "skin of eyelid neoplasm" EXACT [] +synonym: "skin of eyelid neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "skin of eyelid tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of skin of eyelid" EXACT [MONDO:patterns/neoplasm] +xref: Orphanet:98581 {source="MONDO:equivalentTo"} +xref: SCTID:126499002 {source="MONDO:equivalentTo"} +xref: UMLS:CN207033 {source="MONDO:equivalentTo"} +is_a: MONDO:0002235 {source="MONDO:Redundant", source="Orphanet:98581"} ! eyelid neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001457 ! skin of eyelid +relationship: disease_has_location UBERON:0001457 ! skin of eyelid +property_value: exactMatch http://identifiers.org/snomedct/126499002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207033 +property_value: exactMatch Orphanet:98581 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0020173 +name: benign tumor of palpebral epidermis +def: "A benign neoplasm that involves the skin of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98582"} +synonym: "skin of eyelid benign neoplasm" EXACT [MONDO:patterns/location] +xref: Orphanet:98582 {source="MONDO:equivalentTo"} +xref: UMLS:CN207034 {source="MONDO:equivalentTo"} +is_a: MONDO:0020172 {source="MONDO:Redundant", source="Orphanet:98582"} ! palpebral epidermal tumor +is_a: MONDO:0021605 ! benign eyelid neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001457 ! skin of eyelid +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207034 +property_value: exactMatch Orphanet:98582 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0020174 +name: precancerous lesion of palpebral epidermis +def: "A precancerous condition that involves the skin of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98583"} +synonym: "skin of eyelid precancerous condition" EXACT [MONDO:patterns/location] +xref: Orphanet:98583 {source="MONDO:equivalentTo"} +is_a: MONDO:0020172 {source="Orphanet:98583"} ! palpebral epidermal tumor +is_a: MONDO:0021074 ! precancerous condition +intersection_of: MONDO:0021074 ! precancerous condition +intersection_of: disease_has_location UBERON:0001457 ! skin of eyelid +property_value: exactMatch Orphanet:98583 + +[Term] +id: MONDO:0020175 +name: malignant tumor of palpebral epidermis +def: "A cancer that involves the skin of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98584"} +synonym: "cancer of skin of eyelid" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of skin of eyelid" EXACT [MONDO:patterns/cancer] +synonym: "malignant skin of eyelid neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "skin of eyelid cancer" EXACT [MONDO:patterns/location] +xref: Orphanet:98584 {source="MONDO:equivalentTo"} +xref: SCTID:423425006 {source="MONDO:equivalentTo"} +xref: UMLS:CN207035 {source="MONDO:equivalentTo"} +is_a: MONDO:0020172 {source="MONDO:Redundant", source="Orphanet:98584"} ! palpebral epidermal tumor +is_a: MONDO:0021313 ! eyelid cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001457 ! skin of eyelid +property_value: exactMatch http://identifiers.org/snomedct/423425006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207035 +property_value: exactMatch Orphanet:98584 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0020176 +name: palpebral sebaceous gland tumor +def: "A neoplasm (disease) that involves the sebaceous gland of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98585"} +synonym: "neoplasm of sebaceous gland of eyelid" EXACT [MONDO:patterns/neoplasm] +synonym: "sebaceous gland of eyelid neoplasm" EXACT [] +synonym: "sebaceous gland of eyelid neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sebaceous gland of eyelid tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of sebaceous gland of eyelid" EXACT [MONDO:patterns/neoplasm] +xref: Orphanet:98585 {source="MONDO:equivalentTo"} +xref: UMLS:CN207036 {source="MONDO:equivalentTo"} +is_a: MONDO:0002235 {source="MONDO:Redundant", source="Orphanet:98585"} ! eyelid neoplasm +is_a: MONDO:0006963 ! sebaceous gland neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0013231 ! sebaceous gland of eyelid +relationship: disease_has_location UBERON:0013231 ! sebaceous gland of eyelid +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207036 +property_value: exactMatch Orphanet:98585 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0020177 +name: pigmented palpebral tumor +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98586"} +synonym: "pigmented eyelid tumor" EXACT [MONDO:patterns/location] +synonym: "pigmented palpebral neoplasm" EXACT [MONDO:patterns/location] +xref: Orphanet:98586 {source="MONDO:equivalentTo"} +xref: UMLS:CN207037 {source="MONDO:equivalentTo"} +is_a: MONDO:0002235 {source="Orphanet:98586"} ! eyelid neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207037 +property_value: exactMatch Orphanet:98586 + +[Term] +id: MONDO:0020179 +name: palpebral nevus +def: "A melanocytic nevus that involves the skin of eyelid." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98588"} +synonym: "eyelid nevus" EXACT [NCIT:C3880] +synonym: "melanocytic nevus of skin of eyelid" EXACT [MONDO:design_pattern] +synonym: "nevus of eyelid" EXACT [NCIT:C3880] +synonym: "nevus of the eyelid" EXACT [NCIT:C3880] +synonym: "skin of eyelid melanocytic nevus" EXACT [MONDO:patterns/location] +xref: NCIT:C3880 {source="MONDO:equivalentTo"} +xref: Orphanet:98588 {source="MONDO:equivalentTo"} +xref: SCTID:231827008 {source="MONDO:equivalentTo"} +xref: UMLS:C0239460 {source="Orphanet:98588", source="NCIT:C3880", source="MONDO:equivalentTo", source="Orphanet:98588/e"} +is_a: MONDO:0005073 {source="MONDO:Redundant", source="NCIT:C3880"} ! melanocytic nevus +is_a: MONDO:0020173 ! benign tumor of palpebral epidermis +is_a: MONDO:0020177 {source="Orphanet:98588"} ! pigmented palpebral tumor +intersection_of: MONDO:0005073 ! melanocytic nevus +intersection_of: disease_has_location UBERON:0001457 ! skin of eyelid +property_value: exactMatch http://identifiers.org/snomedct/231827008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0239460 +property_value: exactMatch NCIT:C3880 +property_value: exactMatch Orphanet:98588 + +[Term] +id: MONDO:0020204 +name: conjunctival tumor +def: "A benign or malignant neoplasm that affects the conjunctiva. Representative examples include papilloma, squamous cell carcinoma, and melanoma." [NCIT:C2961] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98616"} +synonym: "conjunctiva neoplasm" EXACT [NCIT:C2961] +synonym: "conjunctiva neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "conjunctiva tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2961] +synonym: "conjunctival neoplasm" EXACT [NCIT:C2961] +synonym: "conjunctival neoplasms" EXACT [NCIT:C2961] +synonym: "conjunctival tumor" EXACT [NCIT:C2961] +synonym: "neoplasm of conjunctiva" EXACT [MONDO:patterns/neoplasm, NCIT:C2961] +synonym: "neoplasm of the conjunctiva" EXACT [NCIT:C2961] +synonym: "tumor of conjunctiva" EXACT [MONDO:patterns/neoplasm, NCIT:C2961] +synonym: "tumor of the conjunctiva" EXACT [NCIT:C2961] +xref: NCIT:C2961 {source="MONDO:equivalentTo"} +xref: Orphanet:98616 {source="MONDO:equivalentTo"} +is_a: MONDO:0006170 {source="NCIT:C2961"} ! conjunctival disorder +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C2961"} ! eye neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001811 ! conjunctiva +relationship: has_modifier MONDO:0021136 {source="MONDO:0020198"} ! rare +property_value: exactMatch NCIT:C2961 +property_value: exactMatch Orphanet:98616 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0020208 +name: syndromic myopia +def: "A myopia (disease) that is part of a larger syndrome." [MONDO:patterns/syndromic] +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0001384 myopia +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:98620"} +synonym: "syndrome associated with myopia (disease)" EXACT [MONDO:patterns/syndromic] +synonym: "syndromic myopia (disease)" EXACT [MONDO:patterns/syndromic] +xref: Orphanet:98620 {source="MONDO:equivalentTo"} +xref: UMLS:CN227818 {source="MONDO:equivalentTo"} +is_a: MONDO:0001384 ! myopia +is_a: MONDO:0002254 ! syndromic disease +intersection_of: MONDO:0001384 ! myopia +intersection_of: has_modifier MONDO:0021127 ! has a syndromic presentation +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227818 +property_value: exactMatch Orphanet:98620 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0020213 +name: stromal corneal dystrophy +def: "The stromal corneal dystrophies refer to a group of rare genetically determined corneal dystrophies (CDs) characterized by lesions affecting the corneal stroma, and variable effects on vision depending on the type of dystrophy." [Orphanet:98626] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98626"} +synonym: "corneal dystrophy (disease) of substantia propria of cornea" EXACT [] +synonym: "corneal stromal dystrophy" EXACT [MONDO:0000765] +synonym: "stromal dystrophy" RELATED [DOID:0060442] +synonym: "substantia propria of cornea corneal dystrophy (disease)" EXACT [MONDO:patterns/location] +xref: DOID:0060442 {source="MONDO:equivalentTo"} +xref: ICD10CM:H18.5 {source="Orphanet:98626", source="Orphanet:98626/attributed", source="Orphanet:98626/ntbt"} +xref: ICD9:371.56 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: Orphanet:98626 {source="MONDO:equivalentTo"} +xref: SCTID:231931001 {source="MONDO:equivalentTo"} +xref: UMLS:C0038457 {source="MONDO:equivalentTo", source="Orphanet:98626", source="Orphanet:98626/e"} +is_a: MONDO:0018102 {source="DOID:0060442", source="MONDO:Redundant", source="Orphanet:98626"} ! corneal dystrophy +intersection_of: MONDO:0018102 ! corneal dystrophy +intersection_of: disease_has_location UBERON:0001777 ! substantia propria of cornea +relationship: disease_has_location UBERON:0001777 ! substantia propria of cornea +property_value: exactMatch DOID:0060442 +property_value: exactMatch http://identifiers.org/snomedct/231931001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038457 +property_value: exactMatch Orphanet:98626 +property_value: narrowMatch https://icd.codes/icd10cm/H18.5 + +[Term] +id: MONDO:0020215 +name: syndromic corneal dystrophy +def: "A corneal dystrophy (disease) that is part of a larger syndrome." [MONDO:patterns/syndromic] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98628"} +synonym: "syndrome associated with corneal dystrophy (disease)" EXACT [MONDO:patterns/syndromic] +synonym: "syndromic corneal dystrophy (disease)" EXACT [MONDO:patterns/syndromic] +xref: Orphanet:98628 {source="MONDO:equivalentTo"} +xref: UMLS:CN227823 {source="MONDO:equivalentTo"} +is_a: MONDO:0002254 ! syndromic disease +is_a: MONDO:0018102 {source="MONDO:Redundant", source="Orphanet:98628"} ! corneal dystrophy +intersection_of: MONDO:0018102 ! corneal dystrophy +intersection_of: has_modifier MONDO:0021127 ! has a syndromic presentation +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227823 +property_value: exactMatch Orphanet:98628 + +[Term] +id: MONDO:0020225 +name: syndromic cataract +def: "A cataract (disease) that is part of a larger syndrome." [MONDO:patterns/syndromic] +comment: Reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0005129 cataract +subset: disease_grouping +subset: obsoletion_candidate +subset: ordo_group_of_disorders {source="Orphanet:98641"} +synonym: "syndrome associated with cataract (disease)" EXACT [MONDO:patterns/syndromic] +synonym: "syndromic cataract (disease)" EXACT [MONDO:patterns/syndromic] +xref: Orphanet:98641 {source="MONDO:equivalentTo"} +xref: UMLS:CN227829 {source="MONDO:equivalentTo"} +is_a: MONDO:0002254 ! syndromic disease +is_a: MONDO:0005129 {source="Orphanet:98641"} ! cataract +intersection_of: MONDO:0005129 ! cataract +intersection_of: has_modifier MONDO:0021127 ! has a syndromic presentation +relationship: has_modifier MONDO:0021136 {source="MONDO:0020224"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227829 +property_value: exactMatch Orphanet:98641 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0020238 +name: inherited vitreous-retinal disease +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98657"} +synonym: "genetic vitreoretinal disease" EXACT [MONDO:cjm] +synonym: "genetic vitreous-retinal disease" EXACT [Orphanet:98657] +xref: Orphanet:98657 {source="MONDO:equivalentTo"} +xref: UMLS:CN207063 {source="MONDO:equivalentTo"} +is_a: MONDO:0005283 ! retinal disorder +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0044137 ! vitreous body disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000966 ! retina +intersection_of: disease_has_location UBERON:0001798 ! vitreous body +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207063 +property_value: exactMatch Orphanet:98657 + +[Term] +id: MONDO:0020283 +name: uveitis +def: "An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision." [NCIT:C26909] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:98715"} +synonym: "inflammation of uvea" EXACT [] +synonym: "uvea inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "uveitis" EXACT [MONDO:ambiguous] +synonym: "uveitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: DOID:13141 {source="EFO:1001231", source="MONDO:equivalentTo"} +xref: EFO:1001231 {source="MONDO:equivalentTo"} +xref: HP:0000554 {source="MONDO:otherHierarchy"} +xref: MedDRA:10046851 {source="EFO:1001231", source="Orphanet:98715", source="Orphanet:98715/e"} +xref: MESH:D014605 {source="EFO:1001231", source="DOID:13141", source="MONDO:equivalentTo", source="Orphanet:98715", source="Orphanet:98715/e"} +xref: NCIT:C26909 {source="EFO:1001231", source="DOID:13141", source="MONDO:equivalentTo"} +xref: Orphanet:98715 {source="MONDO:equivalentTo"} +xref: SCTID:128473001 {source="EFO:1001231", source="DOID:13141", source="MONDO:equivalentTo"} +xref: UMLS:C0042164 {source="NCIT:C26909", source="DOID:13141", source="MONDO:equivalentTo", source="Orphanet:98715", source="Orphanet:98715/e"} +is_a: MONDO:0002661 {source="DOID:13141", source="MESH:D014605", source="MONDO:Redundant", source="NCIT:C26909/inferred"} ! uveal disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001768 ! uvea +relationship: disease_has_inflammation_site UBERON:0001768 ! uvea +property_value: closeMatch http://identifiers.org/meddra/10046851 +property_value: exactMatch DOID:13141 +property_value: exactMatch http://identifiers.org/mesh/D014605 +property_value: exactMatch http://identifiers.org/snomedct/128473001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042164 +property_value: exactMatch NCIT:C26909 +property_value: exactMatch Orphanet:98715 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "uveitis (disease)" xsd:string + +[Term] +id: MONDO:0020367 +name: juvenile open angle glaucoma +def: "Juvenile glaucoma (JG) is a rare autosomal dominant open angle glaucoma, characterized by early onset, severe elevation of intra ocular pressure of rapid progression, leading to optic nerve excavation and, when untreated, substantial visual impairment." [Orphanet:98977] +subset: ordo_disease {source="Orphanet:98977"} +synonym: "childhood glaucoma (disease)" EXACT [] +synonym: "glaucoma (disease) of childhood" EXACT [MONDO:patterns/childhood] +synonym: "glaucoma of childhood" EXACT [DOID:1068, ICD9CM:365.14] +synonym: "JOAG" EXACT ABBREVIATION [] +synonym: "juvenile glaucoma" EXACT [] +synonym: "pediatric glaucoma (disease)" EXACT [MONDO:patterns/childhood] +xref: DOID:1068 {source="MONDO:equivalentTo"} +xref: ICD9:365.14 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MedDRA:10064032 {source="Orphanet:98977", source="Orphanet:98977/e"} +xref: OMIM:137750 {source="Orphanet:98977", source="Orphanet:98977/btnt"} +xref: OMIM:231300 {source="MONDO:relatedTo", source="Orphanet:98977", source="Orphanet:98977/ntbt"} +xref: OMIM:608695 {source="Orphanet:98977", source="Orphanet:98977/btnt"} +xref: OMIM:608696 {source="Orphanet:98977", source="Orphanet:98977/btnt"} +xref: OMIM:610535 {source="Orphanet:98977", source="Orphanet:98977/btnt"} +xref: OMIM:611274 {source="Orphanet:98977", source="Orphanet:98977/btnt"} +xref: Orphanet:98977 {source="MONDO:equivalentTo"} +xref: SCTID:71111008 {source="MONDO:equivalentTo"} +xref: UMLS:C2981140 {source="MONDO:equivalentTo", source="Orphanet:98977"} +is_a: MONDO:0005338 {source="DOID:1068"} ! open-angle glaucoma +is_a: MONDO:0015485 {source="Orphanet:98977"} ! primary hereditary glaucoma +intersection_of: MONDO:0005041 ! glaucoma +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: closeMatch http://identifiers.org/meddra/10064032 +property_value: exactMatch DOID:1068 +property_value: exactMatch http://identifiers.org/snomedct/71111008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2981140 +property_value: exactMatch Orphanet:98977 + +[Term] +id: MONDO:0020380 +name: autosomal dominant cerebellar ataxia +def: "A clinically and genetically heterogeneous group of neurodegenerative diseases characterized by a slowly progressive ataxia of gait, stance and limbs, dysarthria and/or oculomotor disorder, due to cerebellar degeneration in the absence of coexisting diseases. The degenerative process can be limited to the cerebellum (ADCA type 3) or may additionally involve the retina (ADCA type 2), optic nerve, ponto-medullary systems, basal ganglia, cerebral cortex, spinal tracts or peripheral nerves (ADCA type 1). In ACDA type 4, a cerebellar syndrome is associated with epilepsy." [https://orcid.org/0000-0001-5208-3432, Orphanet:99] +subset: disease_grouping +subset: gard_rare +subset: ordo_group_of_disorders {source="Orphanet:99"} +synonym: "ADCA" EXACT ABBREVIATION [GARD:0004346, Orphanet:99] +synonym: "autosomal dominant spinocerebellar ataxia" EXACT [Orphanet:99] +synonym: "cerebellar ataxia, autosomal dominant" EXACT [MONDO:patterns/autosomal_dominant] +synonym: "Pierre Marie cerebellar ataxia (formerly)" RELATED [GARD:0004346] +synonym: "SCA" BROAD ABBREVIATION [] +synonym: "spinocerebellar ataxia" BROAD [DOID:1441] +xref: DOID:1441 {source="MONDO:equivalentTo"} +xref: GARD:0004346 {source="MONDO:equivalentTo"} +xref: ICD10CM:G11.8 {source="Orphanet:99/attributed", source="Orphanet:99/ntbt", source="Orphanet:99"} +xref: ICD9:334.3 {source="DOID:1441", source="MONDO:relatedTo", source="MONDO:i2s"} +xref: OMIMPS:164400 {source="MONDO:equivalentTo"} +xref: Orphanet:99 {source="MONDO:equivalentTo"} +xref: SCTID:129609000 {source="DOID:1441", source="MONDO:equivalentTo"} +xref: UMLS:CN227858 {source="MONDO:equivalentTo"} +is_a: MONDO:0000426 ! autosomal dominant disease +is_a: MONDO:0015547 ! genetic dementia +is_a: MONDO:0022687 {source="MONDO:Redundant"} ! cerebellar degeneration +is_a: MONDO:0024237 ! inherited neurodegenerative disorder +is_a: MONDO:0100310 {source="https://orcid.org/0000-0001-5208-3432"} ! hereditary cerebellar ataxia +intersection_of: MONDO:0100310 ! hereditary cerebellar ataxia +intersection_of: has_modifier HP:0000006 ! Autosomal dominant inheritance +relationship: disease_has_feature HP:0002503 ! Spinocerebellar tract degeneration +relationship: disease_has_major_feature MONDO:0001627 ! dementia +property_value: exactMatch DOID:1441 +property_value: exactMatch http://identifiers.org/snomedct/129609000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227858 +property_value: exactMatch https://omim.org/phenotypicSeries/PS164400 +property_value: exactMatch Orphanet:99 +property_value: excluded_subClassOf MONDO:0000437 {source="MONDO:Entailed", source="MONDO:cjm", source="Orphanet:99/inferred"} +property_value: excluded_subClassOf MONDO:0015368 {source="MONDO:0020263-obsoleted"} +property_value: excluded_subClassOf MONDO:0100309 {source="DOID:1441", source="Orphanet:99"} +property_value: narrowMatch https://icd.codes/icd10cm/G11.8 +property_value: seeAlso https://github.com/monarch-initiative/mondo/pull/2571/ xsd:string +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0020516 +name: thymic neuroendocrine carcinoma +def: "Thymic neuroendocrine carcinoma is a type of thymic epithelial neoplasm displaying evidence of neuroendocrine differentiation." [Orphanet:99869] +subset: ordo_disease {source="Orphanet:99869"} +synonym: "neuroendocrine carcinoma of thymus" EXACT [] +synonym: "thymic neuroendocrine carcinoma" EXACT [] +synonym: "thymus neuroendocrine carcinoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: ICD10CM:C37 {source="Orphanet:99869", source="Orphanet:99869/ntbt"} +xref: Orphanet:99869 {source="MONDO:equivalentTo"} +xref: SCTID:716653001 {source="MONDO:equivalentTo"} +xref: UMLS:C2210965 {source="MONDO:equivalentTo"} +xref: UMLS:CN207412 {source="MONDO:equivalentTo"} +is_a: MONDO:0002120 ! neuroendocrine carcinoma +is_a: MONDO:0006451 ! thymic carcinoma +is_a: MONDO:0019964 ! thymic neuroendocrine tumor +intersection_of: MONDO:0002120 ! neuroendocrine carcinoma +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch http://identifiers.org/snomedct/716653001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2210965 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207412 +property_value: exactMatch Orphanet:99869 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: narrowMatch https://icd.codes/icd10cm/C37 + +[Term] +id: MONDO:0020573 +name: inherited disease susceptibility +def: "A latent susceptibility to disease at the genetic level, which may be activated under certain conditions." [MESH:D020022] +subset: predisposition +synonym: "genetic predisposition" RELATED [MESH:D020022] +synonym: "genetic predispositions" RELATED [MESH:D020022] +synonym: "genetic susceptibilities" RELATED [MESH:D020022] +synonym: "genetic susceptibility" RELATED [MESH:D020022] +synonym: "hereditary disease susceptibility" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary predisposition to disease" EXACT [MONDO:patterns/hereditary] +synonym: "predisposition, genetic" RELATED [MESH:D020022] +synonym: "predispositions, genetic" RELATED [MESH:D020022] +synonym: "susceptibilities, genetic" RELATED [MESH:D020022] +synonym: "susceptibility, genetic" RELATED [MESH:D020022] +xref: ICD10CM:Z15 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: MESH:D020022 {source="MONDO:equivalentTo"} +is_a: MONDO:0042489 ! disease susceptibility +intersection_of: MONDO:0042489 {source="MESH:D020022"} ! disease susceptibility +intersection_of: has_modifier MONDO:0021152 {source="MESH:D020022"} ! inherited +relationship: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/D020022 +property_value: exactMatch https://icd.codes/icd10cm/Z15 +created_by: cjm +creation_date: 2017-09-30T12:01:25Z + +[Term] +id: MONDO:0020576 +name: cutaneous vasculitis +def: "Inflammation of the blood vessel wall characterized by palpable purpura." [NCIT:C112210] +synonym: "cutaneous vasculitis" EXACT [NCIT:C112210] +xref: NCIT:C112210 {source="MONDO:equivalentTo"} +xref: UMLS:C0262988 {source="MONDO:equivalentTo"} +is_a: MONDO:0002406 ! dermatitis +is_a: MONDO:0018882 {source="NCIT:C112210"} ! vasculitis +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_has_inflammation_site UBERON:0000014 ! zone of skin +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0262988 +property_value: exactMatch NCIT:C112210 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0020577 +name: childhood gonadal germ cell tumor +def: "A germ cell tumor that arises from the testis or ovary and occurs during childhood." [NCIT:C114801] +synonym: "childhood gonadal germ cell tumor" EXACT [NCIT:C114801] +synonym: "gonadal germ cell tumor of childhood" EXACT [MONDO:patterns/childhood] +synonym: "pediatric gonadal germ cell tumor" EXACT [MONDO:patterns/childhood] +xref: NCIT:C114801 {source="MONDO:equivalentTo"} +xref: UMLS:C3899657 {source="MONDO:equivalentTo"} +is_a: MONDO:0003751 ! childhood germ cell tumor +is_a: MONDO:0018202 ! gonadal germ cell tumor +intersection_of: MONDO:0018202 ! gonadal germ cell tumor +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3899657 +property_value: exactMatch NCIT:C114801 + +[Term] +id: MONDO:0020579 +name: mucositis +def: "Inflammation of the mucous membranes." [NCIT:C115965] +synonym: "inflammation of mucosa" EXACT [] +synonym: "mucosa inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "mucositis" EXACT [NCIT:C115965] +xref: NCIT:C115965 {source="MONDO:equivalentTo"} +is_a: MONDO:0021166 {source="NCIT:C115965"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000344 ! mucosa +relationship: disease_has_inflammation_site UBERON:0000344 ! mucosa +property_value: exactMatch NCIT:C115965 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0020582 +name: benign uterine ligament neoplasm +def: "A non-metastasizing neoplasm that arises from the uterine ligament." [NCIT:C126493] +synonym: "benign uterine ligament neoplasm" EXACT [NCIT:C126493] +xref: NCIT:C126493 {source="MONDO:equivalentTo"} +xref: UMLS:C0865093 {source="MONDO:equivalentTo"} +is_a: MONDO:0000636 ! musculoskeletal system benign neoplasm +is_a: MONDO:0000644 ! cervical benign neoplasm +is_a: MONDO:0021629 {source="NCIT:C126493"} ! uterine ligament neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0036262 ! uterine ligament +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0865093 +property_value: exactMatch NCIT:C126493 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0020584 +name: anemia due to enzyme disorder +def: "Any form of anemia that results from the absence of, or the defective action of, any enzyme." [NCIT:C35472] +synonym: "anemia due to enzyme disorder" EXACT [NCIT:C35472] +xref: NCIT:C35472 {source="MONDO:equivalentTo"} +xref: UMLS:C0494226 {source="MONDO:equivalentTo"} +is_a: MONDO:0002280 {source="NCIT:C35472"} ! anemia +intersection_of: MONDO:0002280 ! anemia +intersection_of: disease_has_basis_in_disruption_of GO:0003824 ! catalytic activity +relationship: disease_has_basis_in_disruption_of GO:0003824 ! catalytic activity +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0494226 +property_value: exactMatch NCIT:C35472 + +[Term] +id: MONDO:0020589 +name: cardiac germ cell tumor +def: "A germ cell tumor that arises within the myocardium or cardiac chambers. The reported cases have been teratomas and yolk sac tumors." [NCIT:C147005] +synonym: "cardiac germ cell tumor" EXACT [NCIT:C147005] +synonym: "heart germ cell tumor" EXACT [NCIT:C147005] +xref: NCIT:C147005 {source="MONDO:equivalentTo"} +is_a: MONDO:0018201 {source="NCIT:C147005"} ! extragonadal germ cell tumor +is_a: MONDO:0021209 {source="NCIT:C147005"} ! heart neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch NCIT:C147005 + +[Term] +id: MONDO:0020590 +name: mycobacterial infectious disease +def: "Infection due to organisms from the genus Mycobacteria." [NCIT:C26831] +synonym: "mycobacterial infection" EXACT [NCIT:C26831] +synonym: "mycobacteriosis" EXACT [] +synonym: "mycobacterium infection" EXACT [NCIT:C26831] +xref: MESH:D009164 {source="MONDO:equivalentTo"} +xref: NCIT:C26831 {source="MONDO:equivalentTo"} +xref: SCTID:88415009 {source="MONDO:equivalentTo"} +xref: UMLS:C0026918 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 {source="NCIT:C26831"} ! bacterial infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:1763 ! Mycobacterium +relationship: disease_has_infectious_agent NCBITaxon:1763 ! Mycobacterium +property_value: exactMatch http://identifiers.org/mesh/D009164 +property_value: exactMatch http://identifiers.org/snomedct/88415009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026918 +property_value: exactMatch NCIT:C26831 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/infectious_disease_by_agent.yaml + +[Term] +id: MONDO:0020592 +name: disorder of pharynx +def: "A non-neoplastic or neoplastic disorder that affects the pharynx. Representative examples include pharyngitis and carcinoma." [NCIT:C26850] +synonym: "chordate pharynx disease" EXACT [] +synonym: "chordate pharynx disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of chordate pharynx" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of chordate pharynx" EXACT [] +synonym: "disorder of chordate pharynx" EXACT [MONDO:patterns/location_top] +synonym: "pharyngeal disease" EXACT [] +synonym: "pharyngeal disorder" EXACT [NCIT:C26850] +xref: GARD:0007266 {source="MONDO:equivalentTo"} +xref: NCIT:C26850 {source="MONDO:equivalentTo"} +xref: SCTID:75860007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 ! respiratory system disorder +is_a: MONDO:0024623 {source="NCIT:C26850"} ! otorhinolaryngologic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001042 ! chordate pharynx +relationship: disease_has_location UBERON:0001042 ! chordate pharynx +property_value: exactMatch http://identifiers.org/snomedct/75860007 +property_value: exactMatch NCIT:C26850 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0020594 +name: abducens nerve disorder +def: "A non-neoplastic or neoplastic disorder affecting the abducens nerve (sixth cranial nerve)." [NCIT:C27593] +synonym: "abducens nerve disease" EXACT [NCIT:C27593] +synonym: "abducens nerve disease or disorder" EXACT [MONDO:patterns/location] +synonym: "abducens nerve disorder" EXACT [NCIT:C27593] +synonym: "disease of abducens nerve" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of abducens nerve" EXACT [] +synonym: "disorder of abducens nerve" EXACT [MONDO:patterns/location_top] +synonym: "VIth nerve disorder" EXACT [NCIT:C27593] +xref: NCIT:C27593 {source="MONDO:equivalentTo"} +xref: SCTID:398925009 {source="MONDO:equivalentTo"} +is_a: MONDO:0003569 {source="NCIT:C27593"} ! cranial nerve neuropathy +is_a: MONDO:0003620 ! peripheral nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001646 ! abducens nerve +relationship: disease_has_location UBERON:0001646 ! abducens nerve +property_value: exactMatch http://identifiers.org/snomedct/398925009 +property_value: exactMatch NCIT:C27593 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0020598 +name: malabsorption syndrome +def: "A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea." [NCIT:C3214] +synonym: "malabsorption" EXACT [NCIT:C3214] +synonym: "malabsorption syndrome" EXACT [NCIT:C3214] +xref: MESH:D008286 {source="MONDO:equivalentTo"} +xref: NCIT:C3214 {source="MONDO:equivalentTo"} +xref: SCTID:32230006 {source="MONDO:equivalentTo"} +xref: UMLS:C0024523 {source="MONDO:equivalentTo"} +is_a: MONDO:0005020 ! intestinal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0050892 ! intestinal absorption +relationship: disease_disrupts GO:0050892 ! intestinal absorption +property_value: exactMatch http://identifiers.org/mesh/D008286 +property_value: exactMatch http://identifiers.org/snomedct/32230006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0024523 +property_value: exactMatch NCIT:C3214 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0020600 +name: acute pharyngitis +def: "An acute and painful inflammatory process that affects the pharynx. It is usually caused by viruses and less often bacteria. Signs and symptoms include discomfort on swallowing, low-grade fever, headache, and earache." [NCIT:C34355] +synonym: "acute pharyngitis" EXACT [NCIT:C34355] +synonym: "pharyngitis, acute" EXACT [MONDO:patterns/acute] +xref: NCIT:C34355 {source="MONDO:equivalentTo"} +xref: SCTID:363746003 {source="MONDO:equivalentTo"} +is_a: MONDO:0002258 {source="NCIT:C34355"} ! pharyngitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0002258 ! pharyngitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch http://identifiers.org/snomedct/363746003 +property_value: exactMatch NCIT:C34355 + +[Term] +id: MONDO:0020634 +name: grade III meningioma +def: "A malignant meningioma with aggressive clinical course. It recurs in approximately 50-78% of the cases. This category includes the anaplastic (malignant) meningioma, papillary meningioma, and rhabdoid meningioma." [NCIT:C38938] +synonym: "grade 3 meningioma" EXACT [NCIT:C38938] +synonym: "grade III meningioma" EXACT [NCIT:C38938] +synonym: "meningioma, malignant" EXACT [NCIT:C38938] +synonym: "WHO grade III meningioma" EXACT [NCIT:C38938] +xref: NCIT:C38938 {source="MONDO:equivalentTo"} +is_a: MONDO:0016642 {source="NCIT:C38938"} ! meningioma +intersection_of: MONDO:0016642 {source="NCIT:C38938"} ! meningioma +intersection_of: has_modifier MONDO:0024493 {source="NCIT:C38938"} ! tumor grade 3, general grading system +relationship: has_modifier MONDO:0024493 ! tumor grade 3, general grading system +property_value: exactMatch NCIT:C38938 + +[Term] +id: MONDO:0020640 +name: autoimmune encephalitis +def: "Inflammation of the brain secondary to an immune response triggered by the body itself." [NCIT:C122414] +subset: gard_rare +synonym: "autoimmune encephalitis" EXACT [NCIT:C122414] +xref: GARD:0011979 {source="MONDO:equivalentTo"} +xref: NCIT:C122414 {source="MONDO:equivalentTo"} +xref: SCTID:95643007 {source="MONDO:equivalentTo"} +is_a: MONDO:0000568 ! autoimmune disorder of central nervous system +is_a: MONDO:0019956 {source="NCIT:C122414"} ! encephalitis +intersection_of: MONDO:0019956 ! encephalitis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch http://identifiers.org/snomedct/95643007 +property_value: exactMatch NCIT:C122414 + +[Term] +id: MONDO:0020641 +name: respiratory tract neoplasm +def: "A benign or malignant, primary or metastatic neoplasm involving the respiratory tract." [NCIT:C3355] +synonym: "neoplasm of respiratory tract" EXACT [MONDO:patterns/neoplasm, NCIT:C3355] +synonym: "neoplasm of the respiratory tract" EXACT [NCIT:C3355] +synonym: "neoplasm, respiratory tract" EXACT [MESH:D012142] +synonym: "neoplasms, respiratory tract" EXACT [MESH:D012142] +synonym: "respiratory system neoplasm" EXACT [EFO:0003853] +synonym: "respiratory tract neoplasm" EXACT [MESH:D012142, NCIT:C3355] +synonym: "respiratory tract tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3355] +synonym: "tract neoplasm, respiratory" EXACT [MESH:D012142] +synonym: "tract neoplasms, respiratory" EXACT [MESH:D012142] +synonym: "tumor of respiratory tract" EXACT [MONDO:patterns/neoplasm, NCIT:C3355] +synonym: "tumor of the respiratory tract" EXACT [NCIT:C3355] +xref: EFO:0003853 {source="MONDO:equivalentTo"} +xref: MESH:D012142 {source="MONDO:equivalentTo"} +xref: NCIT:C3355 {source="MONDO:equivalentTo"} +xref: SCTID:126667002 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 ! neoplasm +is_a: MONDO:0005087 {source="MESH:D012142", source="NCIT:C3355"} ! respiratory system disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000065 ! respiratory tract +relationship: disease_has_location UBERON:0000065 ! respiratory tract +property_value: exactMatch http://identifiers.org/mesh/D012142 +property_value: exactMatch http://identifiers.org/snomedct/126667002 +property_value: exactMatch NCIT:C3355 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0020644 +name: lung non-Hodgkin lymphoma +def: "A rare non-Hodgkin lymphoma that arises in and is confined to the lung at the time of diagnosis. Representative examples include bronchial mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma." [NCIT:C5684] +synonym: "lung non-Hodgkin lymphoma" EXACT [MONDO:patterns/location, NCIT:C5684] +synonym: "lung non-Hodgkin's lymphoma" EXACT [NCIT:C5684] +synonym: "non-Hodgkin lymphoma of lung" EXACT [] +synonym: "primary lung non-Hodgkin's lymphoma" EXACT [NCIT:C5684] +xref: NCIT:C5684 {source="MONDO:equivalentTo"} +xref: UMLS:C1334453 {source="NCIT:C5684", source="MONDO:equivalentTo"} +is_a: MONDO:0003987 {source="NCIT:C5684"} ! lung lymphoma +is_a: MONDO:0018908 {source="NCIT:C5684"} ! non-Hodgkin lymphoma +intersection_of: MONDO:0018908 ! non-Hodgkin lymphoma +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334453 +property_value: exactMatch NCIT:C5684 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0020646 +name: ocular adnexal lymphoma +def: "A non-Hodgkin lymphoma arising from the conjunctiva, lacrimal gland, lacrimal drainage apparatus, eyelids, or other orbital tissues around the eye. The vast majority of cases are extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue, however, other histologic types of lymphomas can originate from ocular adnexal tissues, including rare cases of NK/T-cell lymphomas of nasal type." [NCIT:C88145] +synonym: "non-Hodgkin lymphoma of ocular adnexa" EXACT [] +synonym: "OAL" EXACT ABBREVIATION [NCIT:C88145] +synonym: "ocular adnexa non-Hodgkin lymphoma" EXACT [MONDO:patterns/location] +synonym: "ocular adnexal lymphoma" EXACT [NCIT:C88145] +xref: NCIT:C88145 {source="MONDO:equivalentTo"} +xref: UMLS:C2981712 {source="MONDO:equivalentTo"} +is_a: MONDO:0000462 ! eye adnexa disorder +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0018908 {source="NCIT:C88145"} ! non-Hodgkin lymphoma +intersection_of: MONDO:0018908 ! non-Hodgkin lymphoma +intersection_of: disease_has_location UBERON:0035639 ! ocular adnexa +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2981712 +property_value: exactMatch NCIT:C88145 + +[Term] +id: MONDO:0020650 +name: germ cell tumor of the vulva +xref: ONCOTREE:VGCT {source="MONDO:equivalentTo"} +is_a: MONDO:0005040 ! germ cell tumor +is_a: MONDO:0021049 ! vulvar neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva + +[Term] +id: MONDO:0020653 +name: vaginal adenocarcinoma +def: "An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma." [NCIT:C7981] +synonym: "adenocarcinoma of the vagina" EXACT [NCIT:C7981] +synonym: "adenocarcinoma of vagina" EXACT [NCIT:C7981] +synonym: "vagina adenocarcinoma" EXACT [NCIT:C7981] +synonym: "vaginal adenocarcinoma" EXACT [NCIT:C7981] +xref: NCIT:C7981 {source="MONDO:equivalentTo", source="ONCOTREE:VA"} +xref: ONCOTREE:VA {source="MONDO:equivalentTo"} +is_a: MONDO:0001704 {source="NCIT:C7981"} ! vaginal glandular neoplasm +is_a: MONDO:0004970 {source="NCIT:C7981"} ! adenocarcinoma +is_a: MONDO:0015867 {source="NCIT:C7981"} ! vaginal carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch NCIT:C7981 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0020654 +name: renal pelvis/ureter urothelial carcinoma +def: "A transitional cell carcinoma that arises from the renal pelvis and ureter." [NCIT:C7716] +synonym: "renal pelvis and ureter TCC" EXACT [NCIT:C7716] +synonym: "renal pelvis and ureter transitional cell cancer" EXACT [NCIT:C7716] +synonym: "renal pelvis and ureter transitional cell carcinoma" EXACT [NCIT:C7716] +synonym: "renal pelvis and ureter urothelial carcinoma" EXACT [NCIT:C7716] +synonym: "TCC of renal pelvis and ureter" EXACT [NCIT:C7716] +synonym: "TCC of the renal pelvis and ureter" EXACT [NCIT:C7716] +synonym: "transitional cell cancer of renal pelvis and ureter" EXACT [NCIT:C7716] +synonym: "transitional cell cancer of the renal pelvis and ureter" EXACT [NCIT:C7716] +synonym: "transitional cell carcinoma of renal pelvis and ureter" EXACT [NCIT:C7716] +synonym: "urothelial carcinoma of the renal pelvis and ureter" EXACT [NCIT:C7716] +xref: NCIT:C7716 {source="MONDO:equivalentTo", source="ONCOTREE:UTUC"} +is_a: MONDO:0040679 {source="NCIT:C7716"} ! urothelial carcinoma +intersection_of: MONDO:0040679 ! urothelial carcinoma +intersection_of: disease_has_location UBERON:0036295 ! renal pelvis/ureter +relationship: disease_has_location UBERON:0036295 ! renal pelvis/ureter +property_value: exactMatch NCIT:C7716 + +[Term] +id: MONDO:0020658 +name: infiltrating ureter transitional cell carcinoma +xref: DOID:6845 {source="MONDO:equivalentTo"} +is_a: MONDO:0004010 ! infiltrating renal pelvis/ureter urothelial carcinoma +is_a: MONDO:0004030 {source="DOID:6845"} ! ureter transitional cell carcinoma +intersection_of: MONDO:0040678 ! infiltrating urothelial carcinoma +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch DOID:6845 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0020665 +name: high grade malignant neoplasm +synonym: "high grade malignant neoplasm" EXACT [NCIT:C36046] +xref: NCIT:C36046 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 ! cancer +intersection_of: MONDO:0004992 {source="NCIT:C36046"} ! cancer +intersection_of: has_modifier MONDO:0024497 {source="NCIT:C36046"} ! tumor grade 3 or 4, general grading system +relationship: has_modifier MONDO:0024497 ! tumor grade 3 or 4, general grading system +property_value: exactMatch NCIT:C36046 + +[Term] +id: MONDO:0020669 +name: paranasal sinus cancer +def: "A primary or metastatic malignant neoplasm involving the paranasal sinuses." [NCIT:C7487] +synonym: "malignant accessory sinus neoplasm" EXACT [NCIT:C7487] +synonym: "malignant accessory sinus tumor" EXACT [NCIT:C7487] +synonym: "malignant neoplasm of accessory sinus" EXACT [NCIT:C7487] +synonym: "malignant neoplasm of paranasal sinus" EXACT [NCIT:C7487] +synonym: "malignant neoplasm of the accessory sinus" EXACT [NCIT:C7487] +synonym: "malignant neoplasm of the paranasal sinus" EXACT [NCIT:C7487] +synonym: "malignant paranasal sinus neoplasm" EXACT [NCIT:C7487] +synonym: "malignant paranasal sinus tumor" EXACT [NCIT:C7487] +synonym: "malignant tumor of accessory sinus" EXACT [NCIT:C7487] +synonym: "malignant tumor of paranasal sinus" EXACT [NCIT:C7487] +synonym: "malignant tumor of the accessory sinus" EXACT [NCIT:C7487] +synonym: "malignant tumor of the paranasal sinus" EXACT [NCIT:C7487] +xref: NCIT:C7487 {source="MONDO:equivalentTo"} +is_a: MONDO:0000376 ! respiratory system cancer +is_a: MONDO:0000649 ! sensory system cancer +is_a: MONDO:0002132 ! skull cancer +is_a: MONDO:0005289 {source="NCIT:C7487"} ! paranasal sinus neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch NCIT:C7487 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0020676 +name: disorder of central nervous system or retinal vasculature +comment: Editor note: even though retinal diseases may be located outside the CNS, they are often indicators of CNS disease. Obsolescence reason: out of scope. MONDO:excludeGroupingClass. Term to consider:MONDO:0005071 nervous system disorder +subset: obsoletion_candidate +synonym: "central nervous system or retinal vascular disease" EXACT [] +synonym: "retina/CNS vascular disease" EXACT [] +is_a: MONDO:0005385 ! vascular disorder +intersection_of: MONDO:0005385 ! vascular disorder +intersection_of: disease_has_location UBERON:0036302 ! vasculature of central nervous system plus retina +relationship: disease_has_location UBERON:0036302 ! vasculature of central nervous system plus retina +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0020683 +name: acute disease +def: "Disease having a short and relatively severe course." [MESH:D000208] +synonym: "acute disease" EXACT [MESH:D000208, UMLS:C0001314] +synonym: "acute diseases" EXACT [MESH:D000208] +synonym: "disease, acute" EXACT [MESH:D000208] +xref: ICD9:799.89 +xref: MESH:D000208 {source="MONDO:equivalentTo", source="UMLS:C0001314"} +xref: SCTID:2704003 {source="MONDO:equivalentTo", source="UMLS:C0001314"} +xref: UMLS:C0001314 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: has_modifier PATO:0000389 ! acute +relationship: has_modifier PATO:0000389 ! acute +property_value: exactMatch http://identifiers.org/mesh/D000208 +property_value: exactMatch http://identifiers.org/snomedct/2704003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001314 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acute.yaml + +[Term] +id: MONDO:0020686 +name: acute tonsillitis +def: "An acute inflammation of the tonsils caused by viruses or bacteria. Signs and symptoms include fever, enlargement of the tonsils, difficulty swallowing, and enlargement of the regional lymph nodes." [NCIT:C97142] +synonym: "acute adenoiditis" NARROW [] +synonym: "acute tonsillitis" EXACT [NCIT:C97142, UMLS:C0001361] +synonym: "infective tonsillitis" RELATED [UMLS:C0001361] +xref: ICD9:463 +xref: NCIT:C97142 {source="UMLS:C0001361", source="MONDO:equivalentTo"} +xref: SCTID:17741008 {source="UMLS:C0001361", source="MONDO:equivalentTo"} +xref: UMLS:C0001361 {source="MONDO:equivalentTo"} +is_a: MONDO:0001039 ! tonsillitis +is_a: MONDO:0020683 ! acute disease +intersection_of: MONDO:0001039 ! tonsillitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch http://identifiers.org/snomedct/17741008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0001361 +property_value: exactMatch NCIT:C97142 + +[Term] +id: MONDO:0020696 +name: vitamin B12 deficiency +def: "A disease characterized by low serum levels of vitamin B12, either inherited or acquired." [MONDO:cjm, PMID:16846473] +synonym: "cobalamin deficiency" EXACT [] +synonym: "hypocobalaminemia" EXACT [NCIT:C131684] +synonym: "vitamin b12 deficiency" EXACT [NCIT:C131684] +xref: HP:0100502 {source="MONDO:otherHierarchy"} +xref: ICD9:266.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D014806 {source="MONDO:equivalentTo"} +xref: NCIT:C131684 {source="MONDO:equivalentTo"} +xref: SCTID:190634004 {source="MONDO:equivalentTo"} +xref: UMLS:C0042847 {source="MONDO:equivalentTo", source="NCIT:C131684"} +is_a: MONDO:0005066 ! metabolic disease +is_a: MONDO:0042976 {source="NCIT:C131684"} ! vitamin B deficiency +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_has_basis_in_disruption_of GO:0009235 ! cobalamin metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009235 ! cobalamin metabolic process +relationship: disease_has_feature HP:0100502 ! Vitamin B12 deficiency +property_value: exactMatch http://identifiers.org/mesh/D014806 +property_value: exactMatch http://identifiers.org/snomedct/190634004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042847 +property_value: exactMatch NCIT:C131684 + +[Term] +id: MONDO:0020705 +name: neural tube defects, susceptibility to +subset: predisposition +synonym: "neural tube defects" EXACT [OMIM:182940, OMIM:genemap2] +synonym: "neural tube defects, SUSCEPTIBILITY to" RELATED [OMIM:182940] +synonym: "NTD" RELATED ABBREVIATION [OMIM:182940] +synonym: "spina bifida" RELATED [OMIM:182940] +synonym: "spina bifida, susceptibility to" EXACT [OMIM:182940, OMIM:genemap2] +xref: OMIM:182940 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0018075 ! neural tube defect +relationship: predisposes_towards MONDO:0018075 ! neural tube defect +property_value: exactMatch https://omim.org/entry/182940 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 + +[Term] +id: MONDO:0020710 +name: amnionitis +def: "Inflammation of the amnion." [NCIT:C50459] +synonym: "amnionitides" RELATED [MESH:D002821] +synonym: "amnionitis" EXACT [MESH:D002821, NCIT:C50459] +synonym: "amniotic cavity infection" RELATED [UMLS:C0002631] +synonym: "amniotic infection syndrome" NARROW [PMID:13801291] +synonym: "Infection of amniotic cavity" RELATED [UMLS:C0002631] +synonym: "infection of amniotic cavity" EXACT [] +xref: ICD9:658.40 +xref: NCIT:C50459 {source="MONDO:equivalentTo", source="UMLS:C0002631"} +xref: SCTID:10573002 {source="MONDO:equivalentTo", source="UMLS:C0002631"} +xref: UMLS:C0002631 {source="MONDO:equivalentTo"} +is_a: MONDO:0021166 ! inflammatory disease +is_a: MONDO:0045013 ! disorder of extraembryonic membrane +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000305 ! amnion +relationship: disease_has_inflammation_site UBERON:0000305 ! amnion +property_value: exactMatch http://identifiers.org/snomedct/10573002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0002631 +property_value: exactMatch NCIT:C50459 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/2016 xsd:string + +[Term] +id: MONDO:0020779 +name: cartilage development disorder +def: "Any dysfunction in the growth of cartilage." [NCIT:C34466] +synonym: "abnormal development of cartilage" RELATED [UMLS:C0008449] +synonym: "cartilage development disorder" EXACT [NCIT:C34466] +synonym: "chondrodystrophy" EXACT [NCIT:C34466] +synonym: "Congenital anomaly of cartilage" RELATED [UMLS:C0008449] +xref: ICD9:756.4 +xref: ICD9:756.9 +xref: NCIT:C34466 {source="MONDO:equivalentTo", source="UMLS:C0008449"} +xref: SCTID:67988000 {source="MONDO:equivalentTo", source="UMLS:C0008449"} +xref: UMLS:C0008449 {source="MONDO:equivalentTo"} +is_a: MONDO:0005172 ! skeletal system disorder +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0051216 ! cartilage development +relationship: disease_disrupts GO:0051216 ! cartilage development +relationship: disease_has_location UBERON:0002418 ! cartilage tissue +property_value: exactMatch http://identifiers.org/snomedct/67988000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008449 +property_value: exactMatch NCIT:C34466 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0020782 +name: chronic gingivitis +def: "Chronic painless inflammation of the gums. It is characterized by erythema and edema of the gums and bleeding while brushing the teeth." [NCIT:C34474] +synonym: "Chronic Gingivitis" RELATED [NCIT:C34474] +synonym: "Chronic gingivitis" RELATED [UMLS:C0008684] +synonym: "chronic gingivitis" EXACT [NCIT:C34474] +xref: ICD9:523.1 +xref: ICD9:523.10 +xref: NCIT:C34474 {source="UMLS:C0008684", source="MONDO:equivalentTo"} +xref: SCTID:72621003 {source="UMLS:C0008684", source="MONDO:equivalentTo"} +xref: UMLS:C0008684 {source="MONDO:equivalentTo"} +is_a: MONDO:0002508 {source="NCIT:C34474", source="UMLS:C0008684"} ! gingivitis +intersection_of: MONDO:0002508 ! gingivitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/72621003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0008684 +property_value: exactMatch NCIT:C34474 + +[Term] +id: MONDO:0020799 +name: basal cell neoplasm +def: "A neoplastic proliferation of basal cells in the epidermis (part of the skin) or other anatomic sites (most frequently the salivary glands). The basal cell neoplastic proliferation in the epidermis results in basal cell carcinomas. The basal cell neoplastic proliferation in the salivary glands can be benign, resulting in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas." [NCIT:C3784] +synonym: "basal cell tumor" EXACT [NCIT:C3784] +synonym: "neoplasm, basal cell" RELATED [MESH:D018295] +xref: ICDO:8090/1 {source="NCIT:C3784"} +xref: MESH:D018295 {source="MONDO:equivalentTo"} +xref: NCIT:C3784 {source="MONDO:equivalentTo"} +xref: SCTID:127570002 {source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="MESH:D018295", source="NCIT:C3784"} ! epithelial neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000646 ! basal cell +relationship: disease_arises_from_structure CL:0000646 ! basal cell +property_value: exactMatch http://identifiers.org/mesh/D018295 +property_value: exactMatch http://identifiers.org/snomedct/127570002 +property_value: exactMatch NCIT:C3784 + +[Term] +id: MONDO:0020804 +name: basal cell carcinoma +def: "A carcinoma involving the basal cells." [NCIT:C156767] +synonym: "basal cell cancer" EXACT [] +synonym: "epithelioma, basal cell" EXACT [MESH:D002280] +synonym: "malignant basal cell neoplasm" EXACT [NCIT:C7586] +xref: MESH:D002280 {source="MONDO:equivalentTo"} +xref: NCIT:C156767 {source="MONDO:equivalentTo"} +xref: NCIT:C7586 {source="MONDO:equivalentTo"} +is_a: MONDO:0004993 {source="MESH:D002280", source="NCIT:C156767"} ! carcinoma +is_a: MONDO:0020799 {source="MESH:D002280", source="NCIT:C7586"} ! basal cell neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_arises_from_structure CL:0000646 ! basal cell +property_value: exactMatch http://identifiers.org/mesh/D002280 +property_value: exactMatch NCIT:C156767 +property_value: exactMatch NCIT:C7586 + +[Term] +id: MONDO:0020805 +name: benign basal cell neoplasm +def: "A neoplasm composed of basal cells that remains localized and does not metastasize to other anatomic sites." [NCIT:C4743] +synonym: "benign basal cell tumor" EXACT [] +xref: NCIT:C4743 {source="MONDO:equivalentTo"} +is_a: MONDO:0020799 {source="NCIT:C4743"} ! basal cell neoplasm +is_a: MONDO:0036976 ! benign epithelial neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_arises_from_structure CL:0000646 ! basal cell +property_value: exactMatch NCIT:C4743 + +[Term] +id: MONDO:0020830 +name: diaphragmitis +synonym: "diaphragmatitis" EXACT [UMLS:C0011985] +synonym: "diaphragmitis" EXACT [UMLS:C0011985] +xref: EFO:0000937 {source="MONDO:equivalentTo"} +xref: SCTID:73160007 {source="MONDO:equivalentTo", source="UMLS:C0011985"} +xref: UMLS:C0011985 {source="MONDO:equivalentTo"} +is_a: MONDO:0005728 ! diaphragm disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001103 ! diaphragm +relationship: disease_has_inflammation_site UBERON:0001103 ! diaphragm +property_value: exactMatch http://identifiers.org/snomedct/73160007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0011985 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0020950 +name: viral eye infection +def: "Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus." [MESH:D015828] +synonym: "EYE INFECT VIRAL" RELATED [MESH:D015828] +synonym: "Eye Infection, Viral" RELATED [MESH:D015828] +synonym: "Eye Infections, Viral" RELATED [MESH:D015828] +synonym: "Infection, Viral Eye" RELATED [MESH:D015828] +synonym: "Infection, Viral Ocular" RELATED [MESH:D015828] +synonym: "Infections, Viral Eye" RELATED [MESH:D015828] +synonym: "Infections, Viral Ocular" RELATED [MESH:D015828] +synonym: "OCULAR INFECT VIRAL" RELATED [MESH:D015828] +synonym: "Ocular Infection, Viral" RELATED [MESH:D015828] +synonym: "Ocular Infections, Viral" RELATED [MESH:D015828] +synonym: "VIRAL EYE INFECT" RELATED [MESH:D015828] +synonym: "Viral Eye Infection" RELATED [MESH:D015828] +synonym: "Viral eye infection" RELATED [UMLS:C0015407] +synonym: "viral eye infection" EXACT [] +synonym: "Viral Eye Infections" RELATED [MESH:D015828] +synonym: "Viral Ocular Infection" RELATED [MESH:D015828] +synonym: "Viral Ocular Infections" RELATED [MESH:D015828] +xref: MESH:D015828 {source="MONDO:equivalentTo", source="UMLS:C0015407"} +xref: SCTID:312132001 {source="MONDO:equivalentTo", source="UMLS:C0015407"} +xref: UMLS:C0015407 {source="MONDO:equivalentTo"} +is_a: MONDO:0005108 {source="MESH:D015828"} ! viral infectious disease +is_a: MONDO:0043885 {source="MESH:D015828"} ! eye infectious disorder +intersection_of: MONDO:0005108 ! viral infectious disease +intersection_of: disease_has_location UBERON:0000970 ! eye +property_value: exactMatch http://identifiers.org/mesh/D015828 +property_value: exactMatch http://identifiers.org/snomedct/312132001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015407 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021017 +name: synaptopathy +def: "A disease caused by dysfunction of synapses." [Wikipedia:Synaptopathy] +is_a: MONDO:0005071 {source="https://orcid.org/0000-0001-5208-3432"} ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0045202 ! synapse +relationship: disease_has_basis_in_dysfunction_of GO:0045202 ! synapse +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0021040 +name: pancreatic neoplasm +def: "A benign or malignant neoplasm involving the pancreas." [NCIT:C3305] +synonym: "neoplasm of pancreas" EXACT [MONDO:patterns/neoplasm, NCIT:C3305] +synonym: "neoplasm of the pancreas" EXACT [NCIT:C3305] +synonym: "pancreas" RELATED [ONCOTREE:PANCREAS] +synonym: "pancreas neoplasm" EXACT [NCIT:C3305] +synonym: "pancreas neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pancreas tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3305] +synonym: "pancreatic neoplasm" EXACT [NCIT:C3305] +synonym: "pancreatic tumor" EXACT [NCIT:C3305] +synonym: "tumor of pancreas" EXACT [MONDO:patterns/neoplasm, NCIT:C3305] +synonym: "tumor of the pancreas" EXACT [NCIT:C3305] +xref: EFO:0003860 {source="MONDO:equivalentTo"} +xref: MESH:D010190 {source="MONDO:equivalentTo"} +xref: NCIT:C3305 {source="MONDO:equivalentTo", source="MONDO:exact-label-match"} +xref: ONCOTREE:PANCREAS {source="MONDO:equivalentTo"} +xref: SCTID:126859007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002356 ! pancreas disorder +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001264 ! pancreas +property_value: exactMatch http://identifiers.org/mesh/D010190 +property_value: exactMatch http://identifiers.org/snomedct/126859007 +property_value: exactMatch NCIT:C3305 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021042 +name: glioma +def: "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas." [NCIT:C3059] +synonym: "glial neoplasm" EXACT [NCIT:C3059] +synonym: "glial tumor" EXACT [NCIT:C3059] +synonym: "glioma" EXACT [NCIT:C3059] +synonym: "neoplasm of neuroglia" EXACT [NCIT:C3059] +synonym: "neoplasm of the neuroglia" EXACT [NCIT:C3059] +synonym: "neuroglial neoplasm" EXACT [NCIT:C3059] +synonym: "neuroglial tumor" EXACT [NCIT:C3059] +synonym: "tumor of neuroglia" EXACT [NCIT:C3059] +synonym: "tumor of the neuroglia" EXACT [NCIT:C3059] +xref: GARD:0006513 {source="MONDO:equivalentTo"} +xref: MESH:D005910 {source="MONDO:equivalentTo"} +xref: NCIT:C3059 {source="MONDO:equivalentTo"} +xref: Orphanet:182067 {source="https://github.com/monarch-initiative/mondo/issues/2932", source="MONDO:equivalentTo"} +xref: SCTID:393564001 {source="MONDO:equivalentTo"} +xref: UMLS:C0017638 {source="MONDO:equivalentTo", source="NCIT:C3059"} +is_a: MONDO:0021193 {source="MESH:D005910", source="NCIT:C3059"} ! neuroepithelial neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000125 ! glial cell +relationship: disease_arises_from_structure CL:0000125 ! glial cell +property_value: exactMatch http://identifiers.org/mesh/D005910 +property_value: exactMatch http://identifiers.org/snomedct/393564001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017638 +property_value: exactMatch NCIT:C3059 +property_value: exactMatch Orphanet:182067 + +[Term] +id: MONDO:0021049 +name: vulvar neoplasm +def: "A benign or malignant neoplasm that affects the vulva. Representative examples include Bartholin gland adenoma, vulvar nodular hidradenoma, vulvar carcinoma, and vulvar melanoma." [NCIT:C3443] +synonym: "mammalian vulva neoplasm" EXACT [] +synonym: "mammalian vulva neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "mammalian vulva tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of mammalian vulva" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the vulva" EXACT [NCIT:C3443] +synonym: "neoplasm of vulva" EXACT [NCIT:C3443] +synonym: "tumor of mammalian vulva" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the vulva" EXACT [NCIT:C3443] +synonym: "tumor of vulva" EXACT [NCIT:C3443] +synonym: "vulva neoplasm" EXACT [NCIT:C3443] +synonym: "vulva tumor" EXACT [NCIT:C3443] +synonym: "vulval neoplasm" EXACT [DOID:1245] +synonym: "vulvar neoplasm" EXACT [DOID:1245, NCIT:C3443] +synonym: "vulvar tumor" EXACT [DOID:1245, NCIT:C3443] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3443 {source="MONDO:equivalentTo"} +xref: SCTID:126922007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002187 {source="NCIT:C3443"} ! vulvar disease +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C3443"} ! female reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +relationship: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch http://identifiers.org/snomedct/126922007 +property_value: exactMatch NCIT:C3443 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021050 +name: vaginal neoplasm +def: "A benign or malignant neoplasm affecting the vagina. Representative examples of benign neoplasms include squamous papilloma and melanocytic nevus. Representative examples of malignant neoplasms include carcinoma, melanoma, and sarcoma." [NCIT:C3437] +comment: Editor note: we place the oncotree class here for consistency of placing of child classes, although it represents both vagina and vulva +synonym: "neoplasm of the vagina" EXACT [NCIT:C3437] +synonym: "neoplasm of vagina" EXACT [MONDO:patterns/neoplasm, NCIT:C3437] +synonym: "tumor of the vagina" EXACT [NCIT:C3437] +synonym: "tumor of vagina" EXACT [MONDO:patterns/neoplasm, NCIT:C3437] +synonym: "vagina neoplasm" EXACT [NCIT:C3437] +synonym: "vagina neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "vagina tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3437] +synonym: "vaginal neoplasm" EXACT [NCIT:C3437] +synonym: "vaginal tumor" EXACT [NCIT:C3437] +xref: EFO:1001447 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3437 {source="MONDO:equivalentTo"} +xref: ONCOTREE:VULVA {source="MONDO:relatedTo"} +xref: SCTID:126921000 {source="MONDO:equivalentTo"} +is_a: MONDO:0001433 {source="MONDO:Redundant", source="NCIT:C3437"} ! vaginal disorder +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C3437"} ! female reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000996 ! vagina +property_value: exactMatch http://identifiers.org/snomedct/126921000 +property_value: exactMatch NCIT:C3437 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021052 +name: parasympathetic paraganglioma +def: "A benign or malignant, usually non-functioning, extra-adrenal paraganglioma that arises from paraganglia located along the parasympathetic nerves. Representative examples include aorticopulmonary, carotid body, jugulotympanic, and mediastinal paragangliomas." [NCIT:C4217] +synonym: "paraganglioma of parasympathetic nervous system" EXACT [MONDO:design_pattern] +synonym: "parasympathetic Extra-adrenal paraganglioma" EXACT [NCIT:C4217] +synonym: "parasympathetic nervous system paraganglioma" EXACT [MONDO:patterns/location] +synonym: "parasympathetic paraganglioma" EXACT [NCIT:C4217] +synonym: "parasympathetic Paraganglionic neoplasm" EXACT [NCIT:C4217] +xref: ICDO:8682/1 {source="NCIT:C4217"} +xref: NCIT:C4217 {source="MONDO:equivalentTo"} +xref: UMLS:C0334416 {source="MONDO:equivalentTo", source="NCIT:C4217"} +is_a: MONDO:0000448 {source="MONDO:Redundant", source="NCIT:C4217/inferred"} ! paraganglioma +is_a: MONDO:0044995 ! parasympathetic nervous system disorder +intersection_of: MONDO:0000448 {source="NCIT:C4217"} ! paraganglioma +intersection_of: disease_has_location UBERON:0000011 {source="NCIT:C4217"} ! parasympathetic nervous system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334416 +property_value: exactMatch NCIT:C4217 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021053 +name: carotid body paraganglioma +def: "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to or in the bifurcation of the common carotid artery. Most patients present with a slow growing, painless mass in the neck." [NCIT:C2932] +synonym: "carotid body chemodectoma" RELATED [NCIT:C2932] +synonym: "carotid body paraganglioma" EXACT [MONDO:patterns/location, NCIT:C2932] +synonym: "carotid body tumor" RELATED [NCIT:C2932] +synonym: "chemodectoma" RELATED [NCIT:C2932] +synonym: "chemodectoma, undetermined" RELATED [NCIT:C2932] +synonym: "paraganglioma of carotid body" EXACT [NCIT:C2932] +synonym: "paraganglioma of the carotid body" RELATED [NCIT:C2932] +synonym: "tumor of carotid body" RELATED [NCIT:C2932] +synonym: "tumor of the carotid body" RELATED [NCIT:C2932] +xref: GARD:0010598 {source="MONDO:equivalentTo"} +xref: ICDO:8692/1 {source="NCIT:C2932"} +xref: NCIT:C2932 {source="MONDO:equivalentTo"} +xref: UMLS:C0007279 {source="MONDO:equivalentTo", source="NCIT:C2932"} +is_a: MONDO:0000473 ! arterial disorder +is_a: MONDO:0006239 {source="NCIT:C2932"} ! head and neck paraganglioma +is_a: MONDO:0021052 {source="NCIT:C2932"} ! parasympathetic paraganglioma +is_a: MONDO:0021080 ! blood vessel neoplasm +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: disease_has_location UBERON:0001629 ! carotid body +relationship: disease_has_location UBERON:0001629 ! carotid body +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007279 +property_value: exactMatch NCIT:C2932 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021058 +name: neoplastic syndrome +def: "A broad classification for disorders in which the development of neoplasms typically occur in association with a characteristic set of signs or symptoms. These disorders may be inherited or acquired." [NCIT:C54705] +synonym: "cancer-related syndrome" EXACT [NCIT:C54705] +synonym: "neoplastic syndrome" EXACT [NCIT:C54705] +synonym: "tumor syndrome" EXACT [NCIT:C54705] +xref: NCIT:C54705 {source="MONDO:equivalentTo"} +is_a: MONDO:0002254 {source="MONDO:Redundant", source="NCIT:C54705"} ! syndromic disease +is_a: MONDO:0023370 {source="MONDO:Redundant", source="MONDO:cjm", source="MONDO:indirect"} ! neoplastic disease or syndrome +intersection_of: MONDO:0002254 ! syndromic disease +intersection_of: disease_has_major_feature MONDO:0005070 ! neoplasm +relationship: disease_has_major_feature MONDO:0005070 ! neoplasm +relationship: has_modifier MONDO:0021136 {source="MONDO:0016645"} ! rare +property_value: exactMatch NCIT:C54705 + +[Term] +id: MONDO:0021063 +name: malignant colon neoplasm +def: "A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C9242] +synonym: "cancer of colon" EXACT [MONDO:patterns/cancer] +synonym: "colon cancer" EXACT [MONDO:patterns/location] +synonym: "colon neoplasm, malignant" EXACT [NCIT:C9242] +synonym: "colon tumor, malignant" EXACT [NCIT:C9242] +synonym: "malignant colon neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9242] +synonym: "malignant colon tumor" EXACT [NCIT:C9242] +synonym: "malignant colonic neoplasm" EXACT [NCIT:C9242] +synonym: "malignant colonic tumor" EXACT [NCIT:C9242] +synonym: "malignant neoplasm of colon" EXACT [MONDO:patterns/cancer, NCIT:C9242] +synonym: "malignant neoplasm of the colon" EXACT [NCIT:C9242] +synonym: "malignant tumor of colon" EXACT [NCIT:C9242] +synonym: "malignant tumor of the colon" EXACT [NCIT:C9242] +xref: DOID:219 {source="EFO:0004288", source="MONDO:equivalentTo"} +xref: ICD9:153 {source="DOID:219"} +xref: ICD9:153.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:153.9 {source="DOID:219", source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9242 {source="MONDO:equivalentTo"} +xref: SCTID:363406005 {source="DOID:219", source="MONDO:equivalentTo"} +xref: UMLS:C0007102 {source="DOID:219", source="MONDO:equivalentTo", source="NCIT:C9242"} +is_a: MONDO:0005401 {source="MONDO:Redundant", source="NCIT:C9242"} ! colonic neoplasm +is_a: MONDO:0005575 {source="DOID:219", source="MONDO:Redundant", source="NCIT:C9242"} ! colorectal cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001155 ! colon +property_value: exactMatch DOID:219 +property_value: exactMatch http://identifiers.org/snomedct/363406005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007102 +property_value: exactMatch NCIT:C9242 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021064 +name: jugulotympanic paraganglioma +def: "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the base of the skull and middle ear." [NCIT:C3061] +subset: gard_rare +synonym: "basicranium parasympathetic paraganglioma" EXACT [MONDO:patterns/location] +synonym: "glomus jugulare neoplasm" BROAD [NCIT:C3061] +synonym: "glomus jugulare tumor" BROAD [NCIT:C3061] +synonym: "Glomus tumor" RELATED [GARD:0010599] +synonym: "jugular paraganglioma" EXACT [NCIT:C3061] +synonym: "jugulotympanic paraganglioma" EXACT [NCIT:C3061] +synonym: "neoplasm of glomus jugulare" EXACT [NCIT:C3061] +synonym: "neoplasm of the glomus jugulare" EXACT [NCIT:C3061] +synonym: "Paraganglioma - glomus jugulare" RELATED [GARD:0010599] +synonym: "parasympathetic paraganglioma of basicranium" EXACT [MONDO:design_pattern] +synonym: "tumor of glomus jugulare" EXACT [NCIT:C3061] +synonym: "tumor of the glomus jugulare" EXACT [NCIT:C3061] +xref: GARD:0010599 {source="MONDO:equivalentTo"} +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICDO:8690/1 {source="NCIT:C3061"} +xref: NCIT:C3061 {source="MONDO:equivalentTo"} +xref: SCTID:127030001 {source="MONDO:equivalentTo"} +xref: UMLS:C0017671 {source="NCIT:C3061", source="GARD:0010599", source="MONDO:equivalentTo"} +is_a: MONDO:0002785 ! skull base neoplasm +is_a: MONDO:0006239 {source="MONDO:Redundant", source="NCIT:C3061"} ! head and neck paraganglioma +is_a: MONDO:0021052 {source="MONDO:Redundant", source="NCIT:C3061"} ! parasympathetic paraganglioma +is_a: MONDO:0021257 {source="MONDO:cjm"} ! glomus jugulare neoplasm +is_a: MONDO:0023603 ! hereditary disorder of connective tissue +is_a: MONDO:0024499 ! vascular bone neoplasm +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0021052 {source="NCIT:C3061"} ! parasympathetic paraganglioma +intersection_of: disease_has_location UBERON:0002517 {source="NCIT:C3061"} ! basicranium +property_value: exactMatch http://identifiers.org/snomedct/127030001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017671 +property_value: exactMatch NCIT:C3061 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021065 +name: pleural neoplasm +def: "A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura." [NCIT:C3332] +synonym: "neoplasm of pleura" EXACT [MONDO:patterns/neoplasm, NCIT:C3332] +synonym: "neoplasm of pleural cavity" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the pleura" EXACT [NCIT:C3332] +synonym: "pleura neoplasm" EXACT [] +synonym: "pleura neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pleura tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "pleural cavity neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pleural cavity tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "pleural neoplasm" EXACT [NCIT:C3332] +synonym: "pleural tumor" EXACT [NCIT:C3332] +synonym: "tumor of pleura" EXACT [MONDO:patterns/neoplasm, NCIT:C3332] +synonym: "tumor of the pleura" EXACT [NCIT:C3332] +xref: MESH:D010997 {source="MONDO:equivalentTo"} +xref: NCIT:C3332 {source="MONDO:equivalentTo"} +xref: ONCOTREE:PLEURA {source="MONDO:equivalentTo"} +xref: SCTID:126719004 {source="MONDO:equivalentTo"} +xref: UMLS:C0032229 {source="MONDO:equivalentTo", source="NCIT:C3332"} +is_a: MONDO:0002037 {source="MONDO:Redundant", source="NCIT:C3332"} ! pleural disorder +is_a: MONDO:0020641 ! respiratory tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000977 ! pleura +property_value: exactMatch http://identifiers.org/mesh/D010997 +property_value: exactMatch http://identifiers.org/snomedct/126719004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0032229 +property_value: exactMatch NCIT:C3332 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021066 +name: urinary system neoplasm +def: "A benign or malignant, primary or metastatic neoplasm involving the urinary system. --2003" [NCIT:C3431] +comment: Editor note: note the ONCOTREE class is more general than just bladder +synonym: "neoplasm of renal system" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the urinary system" EXACT [NCIT:C3431] +synonym: "neoplasm of the urinary tract" EXACT [NCIT:C3431] +synonym: "neoplasm of urinary system" EXACT [NCIT:C3431] +synonym: "neoplasm of urinary tract" EXACT [NCIT:C3431] +synonym: "renal system neoplasm" EXACT [] +synonym: "renal system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "renal system tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of renal system" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the urinary system" EXACT [NCIT:C3431] +synonym: "tumor of the urinary tract" EXACT [NCIT:C3431] +synonym: "tumor of urinary system" EXACT [NCIT:C3431] +synonym: "tumor of urinary tract" EXACT [NCIT:C3431] +synonym: "urinary system neoplasm" EXACT [NCIT:C3431] +synonym: "urinary system tumor" EXACT [NCIT:C3431] +synonym: "urinary tract neoplasm" EXACT [NCIT:C3431] +synonym: "urinary tract tumor" EXACT [NCIT:C3431] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3431 {source="MONDO:equivalentTo"} +xref: ONCOTREE:BLADDER {source="MONDO:equivalentTo"} +xref: SCTID:126879004 {source="MONDO:equivalentTo"} +is_a: MONDO:0002118 ! urinary system disorder +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C3431/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch http://identifiers.org/snomedct/126879004 +property_value: exactMatch NCIT:C3431 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021067 +name: mediastinal germ cell tumor +def: "A germ cell tumor that arises from the mediastinum. Representative examples include seminoma, embryonal carcinoma, yolk sac tumor, teratoma, and mixed germ cell tumor." [NCIT:C6437] +synonym: "germ cell neoplasm of mediastinum" EXACT [NCIT:C6437] +synonym: "germ cell neoplasm of the mediastinum" EXACT [NCIT:C6437] +synonym: "germ cell tumor of mediastinum" EXACT [NCIT:C6437] +synonym: "germ cell tumor of the mediastinum" EXACT [NCIT:C6437] +synonym: "mediastinal germ cell neoplasm" EXACT [NCIT:C6437] +synonym: "mediastinal germ cell tumor" EXACT [NCIT:C6437] +synonym: "mediastinum germ cell tumor" EXACT [MONDO:patterns/location] +synonym: "thymic germ cell tumor" EXACT [NCIT:C6437] +xref: NCIT:C6437 {source="MONDO:equivalentTo"} +xref: UMLS:C1334655 {source="MONDO:equivalentTo", source="NCIT:C6437"} +is_a: MONDO:0018201 {source="NCIT:C6437"} ! extragonadal germ cell tumor +is_a: MONDO:0021386 {source="MONDO:Redundant", source="NCIT:C6437"} ! neoplasm of mediastinum +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334655 +property_value: exactMatch NCIT:C6437 + +[Term] +id: MONDO:0021068 +name: ovarian neoplasm +def: "A benign, borderline, or malignant neoplasm involving the ovary." [NCIT:C4984] +synonym: "neoplasm of ovary" EXACT [MONDO:patterns/neoplasm, NCIT:C4984] +synonym: "neoplasm of the ovary" EXACT [NCIT:C4984] +synonym: "ovarian neoplasm" EXACT [NCIT:C4984] +synonym: "ovarian tumor" EXACT [NCIT:C4984] +synonym: "ovarian tumors" EXACT [NCIT:C4984] +synonym: "ovary neoplasm" EXACT [] +synonym: "ovary neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "ovary tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of ovary" EXACT [MONDO:patterns/neoplasm, NCIT:C4984] +synonym: "tumor of the ovary" EXACT [NCIT:C4984] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4984 {source="MONDO:equivalentTo"} +xref: SCTID:123843001 {source="MONDO:equivalentTo"} +xref: UMLS:CN236629 {source="MONDO:equivalentTo"} +is_a: MONDO:0005558 {source="MONDO:Redundant", source="NCIT:C4984"} ! ovarian disorder +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C4984"} ! female reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch http://identifiers.org/snomedct/123843001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236629 +property_value: exactMatch NCIT:C4984 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021069 +name: malignant endocrine neoplasm +def: "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma." [NCIT:C3575] +synonym: "cancer of endocrine gland" EXACT [MONDO:patterns/cancer] +synonym: "endocrine cancer" EXACT [NCIT:C3575] +synonym: "endocrine gland cancer" EXACT [MONDO:patterns/location] +synonym: "endocrine neoplasm" BROAD [DOID:170] +synonym: "endocrine neoplasm, malignant" EXACT [NCIT:C3575] +synonym: "Endocrine tumor" EXACT [DOID:170] +synonym: "malignant endocrine gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3575] +synonym: "malignant endocrine gland tumor" EXACT [NCIT:C3575] +synonym: "malignant endocrine neoplasm" EXACT [NCIT:C3575] +synonym: "malignant endocrine tumor" EXACT [NCIT:C3575] +synonym: "malignant neoplasm of endocrine gland" EXACT [MONDO:patterns/cancer, NCIT:C3575] +synonym: "malignant neoplasm of the endocrine gland" EXACT [NCIT:C3575] +synonym: "malignant tumor of endocrine gland" EXACT [NCIT:C3575] +synonym: "malignant tumor of the endocrine gland" EXACT [NCIT:C3575] +synonym: "malignant tumour of endocrine gland" EXACT [DOID:170] +synonym: "neoplasm of endocrine system" EXACT [DOID:170] +xref: DOID:170 {source="MONDO:equivalentTo"} +xref: ICD9:194.9 {source="DOID:170"} +xref: MESH:D004701 {source="DOID:170", source="MONDO:equivalentTo"} +xref: NCIT:C3575 {source="DOID:170", source="MONDO:equivalentTo"} +is_a: MONDO:0002082 {source="MONDO:Redundant", source="NCIT:C3575"} ! endocrine gland neoplasm +is_a: MONDO:0004992 ! cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002368 ! endocrine gland +property_value: exactMatch DOID:170 +property_value: exactMatch http://identifiers.org/mesh/D004701 +property_value: exactMatch NCIT:C3575 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021070 +name: sublingual gland carcinoma +def: "A carcinoma that arises from the sublingual gland. Representative examples include cystadenocarcinoma and mucoepidermoid carcinoma." [NCIT:C8397] +synonym: "carcinoma of sublingual gland" EXACT [MONDO:patterns/carcinoma, NCIT:C8397] +synonym: "carcinoma of the sublingual gland" EXACT [NCIT:C8397] +synonym: "sublingual gland cancer" BROAD [NCIT:C8397] +synonym: "sublingual gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C8397] +xref: NCIT:C8397 {source="MONDO:equivalentTo"} +xref: SCTID:254466003 {source="MONDO:equivalentTo"} +xref: UMLS:C0345611 {source="NCIT:C8397", source="MONDO:equivalentTo"} +is_a: MONDO:0004667 {source="MONDO:Redundant", source="NCIT:C8397"} ! sublingual gland cancer +is_a: MONDO:0006284 {source="MONDO:Redundant", source="NCIT:C8397"} ! major salivary gland carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001832 ! sublingual gland +property_value: exactMatch http://identifiers.org/snomedct/254466003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345611 +property_value: exactMatch NCIT:C8397 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021071 +name: laryngeal neoplasm +def: "A benign or malignant neoplasm involving the larynx." [NCIT:C3156] +synonym: "laryngeal neoplasm" EXACT [NCIT:C3156] +synonym: "laryngeal tumor" EXACT [NCIT:C3156] +synonym: "larynx neoplasm" EXACT [NCIT:C3156] +synonym: "larynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "larynx tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3156] +synonym: "neoplasm of larynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3156] +synonym: "neoplasm of the larynx" EXACT [NCIT:C3156] +synonym: "tumor of larynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3156] +synonym: "tumor of the larynx" EXACT [NCIT:C3156] +xref: EFO:0003817 {source="MONDO:equivalentTo"} +xref: MESH:D007822 {source="MONDO:equivalentTo"} +xref: NCIT:C3156 {source="MONDO:equivalentTo"} +xref: SCTID:126692004 {source="MONDO:equivalentTo"} +xref: UMLS:C0023055 {source="MONDO:equivalentTo", source="NCIT:C3156"} +is_a: MONDO:0004382 {source="MESH:D007822", source="MONDO:Redundant", source="NCIT:C3156"} ! laryngeal disorder +is_a: MONDO:0020641 ! respiratory tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001737 ! larynx +property_value: exactMatch http://identifiers.org/mesh/D007822 +property_value: exactMatch http://identifiers.org/snomedct/126692004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0023055 +property_value: exactMatch NCIT:C3156 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021072 +name: sympathetic paraganglioma +def: "A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves. It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla. The latter are commonly referred to as pheochromocytomas. Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas. Clinical signs are related to the secretion of catecholamines resulting in hypertension." [NCIT:C4216] +synonym: "chromaffin neoplasm" EXACT [NCIT:C4216] +synonym: "chromaffin tumor" EXACT [NCIT:C4216] +synonym: "Chromaffinoma" EXACT [NCIT:C4216] +synonym: "paraganglioma of sympathetic nervous system" EXACT [MONDO:design_pattern] +synonym: "sympathetic nervous system paraganglioma" EXACT [MONDO:patterns/location] +synonym: "sympathetic paraganglioma" EXACT [NCIT:C4216] +synonym: "sympathetic Paraganglionic neoplasm" EXACT [NCIT:C4216] +xref: ICDO:8681/1 {source="NCIT:C4216"} +xref: MESH:C531777 {source="MONDO:equivalentTo"} +xref: NCIT:C4216 {source="MONDO:equivalentTo"} +xref: SCTID:399343007 {source="MONDO:equivalentTo"} +is_a: MONDO:0000448 {source="MONDO:Redundant", source="NCIT:C4216"} ! paraganglioma +is_a: MONDO:0005626 {source="MONDO:Redundant", source="NCIT:C4216/inferred"} ! epithelial neoplasm +is_a: MONDO:0044993 ! sympathetic nervous system disorder +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: disease_has_location UBERON:0000013 ! sympathetic nervous system +relationship: disease_arises_from_structure CL:0000166 {source="NCIT:C4216"} ! chromaffin cell +property_value: exactMatch http://identifiers.org/mesh/C531777 +property_value: exactMatch http://identifiers.org/snomedct/399343007 +property_value: exactMatch NCIT:C4216 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021073 +name: paraneoplastic syndrome +def: "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm." [NCIT:C3311] +synonym: "paraneoplastic syndrome" EXACT [NCIT:C3311] +xref: MESH:D010257 {source="MONDO:equivalentTo"} +xref: NCIT:C3311 {source="MONDO:equivalentTo"} +xref: SCTID:49783001 {source="MONDO:equivalentTo"} +xref: UMLS:C0030472 {source="MONDO:equivalentTo", source="NCIT:C3311"} +is_a: MONDO:0002254 {source="NCIT:C3311"} ! syndromic disease +property_value: exactMatch http://identifiers.org/mesh/D010257 +property_value: exactMatch http://identifiers.org/snomedct/49783001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0030472 +property_value: exactMatch NCIT:C3311 + +[Term] +id: MONDO:0021074 +name: precancerous condition +def: "A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia." [NCIT:C3341] +comment: Editor note: check classification. Also consider changing def, NCIT defines as disease. Also consider a grouping for this and paraneoplastic syndrome +synonym: "precancerous condition" EXACT [NCIT:C3341] +synonym: "precancerous state" EXACT [NCIT:C3341] +synonym: "premalignant condition" EXACT [NCIT:C3341] +synonym: "premalignant state" EXACT [NCIT:C3341] +xref: MESH:D011230 {source="MONDO:equivalentTo"} +xref: NCIT:C3341 {source="MONDO:equivalentTo"} +is_a: MONDO:0045024 {source="MONDO:Redundant"} ! cancer or benign tumor +property_value: exactMatch http://identifiers.org/mesh/D011230 +property_value: exactMatch NCIT:C3341 + +[Term] +id: MONDO:0021076 +name: pancreatic exocrine neoplasm +def: "A benign or malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue." [NCIT:C4445] +synonym: "exocrine pancreas neoplasm" EXACT [NCIT:C4445] +synonym: "exocrine pancreas neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "exocrine pancreas tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4445] +synonym: "neoplasm of exocrine pancreas" EXACT [MONDO:patterns/neoplasm, NCIT:C4445] +synonym: "neoplasm of the exocrine pancreas" EXACT [NCIT:C4445] +synonym: "pancreatic exocrine neoplasm" EXACT [NCIT:C4445] +synonym: "pancreatic exocrine tumor" EXACT [NCIT:C4445] +synonym: "tumor of exocrine pancreas" EXACT [MONDO:patterns/neoplasm, NCIT:C4445] +synonym: "tumor of the exocrine pancreas" EXACT [NCIT:C4445] +xref: ICD9:235.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4445 {source="MONDO:equivalentTo"} +xref: SCTID:254604005 {source="MONDO:equivalentTo"} +xref: UMLS:C0345920 {source="MONDO:equivalentTo", source="NCIT:C4445"} +is_a: MONDO:0021040 {source="MONDO:Redundant", source="NCIT:C4445"} ! pancreatic neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000017 ! exocrine pancreas +relationship: disease_has_location UBERON:0000017 ! exocrine pancreas +property_value: exactMatch http://identifiers.org/snomedct/254604005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345920 +property_value: exactMatch NCIT:C4445 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021078 +name: glandular papilloma +synonym: "glandular papilloma" EXACT [NCIT:C6880] +xref: NCIT:C6880 {source="MONDO:equivalentTo"} +xref: UMLS:C0205650 {source="NCIT:C6880", source="MONDO:directSiblingOf"} +is_a: MONDO:0002363 {source="MONDO:Redundant", source="NCIT:C6880"} ! papilloma +is_a: MONDO:0024276 {source="MONDO:Redundant", source="NCIT:C6880"} ! glandular cell neoplasm +intersection_of: MONDO:0002363 {source="NCIT:C6880"} ! papilloma +intersection_of: MONDO:0024276 {source="NCIT:C6880"} ! glandular cell neoplasm +property_value: exactMatch NCIT:C6880 + +[Term] +id: MONDO:0021079 +name: childhood neoplasm +def: "A benign or malignant neoplasm arising during childhood." [NCIT:C6283] +synonym: "childhood neoplasm" EXACT [NCIT:C6283] +synonym: "childhood neoplasm (disease)" EXACT [] +synonym: "childhood tumor" EXACT [NCIT:C6283] +synonym: "neoplasm (disease) of childhood" EXACT [MONDO:patterns/childhood] +synonym: "pediatric neoplasm" EXACT [NCIT:C6283] +synonym: "pediatric neoplasm (disease)" EXACT [MONDO:patterns/childhood] +synonym: "pediatric tumor" EXACT [NCIT:C6283] +xref: NCIT:C6283 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C6283/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +relationship: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch NCIT:C6283 + +[Term] +id: MONDO:0021080 +name: blood vessel neoplasm +def: "A neoplasm arising from arteries or veins." [NCIT:C7387] +synonym: "blood vessel neoplasm" EXACT [NCIT:C7387] +synonym: "blood vessel neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "blood vessel tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C7387] +synonym: "neoplasm of blood vessel" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of blood vessel" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C7387 {source="MONDO:equivalentTo"} +xref: SCTID:126736007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005385 ! vascular disorder +is_a: MONDO:0024296 {source="MONDO:Redundant", source="NCIT:C7387"} ! vascular neoplasm +intersection_of: MONDO:0005070 {source="NCIT:C7387"} ! neoplasm +intersection_of: disease_has_location UBERON:0001981 {source="NCIT:C7387"} ! blood vessel +relationship: disease_arises_from_structure UBERON:0004638 {source="NCIT:C7387"} ! blood vessel endothelium +relationship: disease_has_location UBERON:0001981 ! blood vessel +property_value: exactMatch http://identifiers.org/snomedct/126736007 +property_value: exactMatch NCIT:C7387 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021084 +name: vision disorder +def: "Any impairment to the vision." [NCIT:C35126] +synonym: "disorder of vision" EXACT [] +synonym: "disorder of visual system" BROAD [NCIT:C35126] +synonym: "vision disorder" EXACT [NCIT:C35126] +synonym: "visual disorder" EXACT [NCIT:C35126] +synonym: "visual Field disorder" RELATED [NCIT:C35126] +synonym: "visual system disorder" BROAD [NCIT:C35126] +xref: MedDRA:10047518 {source="MONDO:equivalentTo"} +xref: MESH:D014786 {source="MONDO:equivalentTo"} +xref: NCIT:C35126 {source="MONDO:equivalentTo"} +xref: SCTID:95677002 {source="MONDO:equivalentTo"} +xref: UMLS:C0042790 {source="MONDO:equivalentTo", source="NCIT:C35126"} +is_a: MONDO:0024417 ! perceptual disorders +is_a: MONDO:0024458 ! disorder of visual system +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0007601 ! visual perception +relationship: disease_disrupts GO:0007601 ! visual perception +property_value: exactMatch http://identifiers.org/meddra/10047518 +property_value: exactMatch http://identifiers.org/mesh/D014786 +property_value: exactMatch http://identifiers.org/snomedct/95677002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042790 +property_value: exactMatch NCIT:C35126 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4614 + +[Term] +id: MONDO:0021085 +name: gastric neoplasm +def: "A benign or malignant neoplasm involving the stomach." [NCIT:C3387] +synonym: "gastric neoplasm" EXACT [NCIT:C3387] +synonym: "gastric tumor" EXACT [NCIT:C3387] +synonym: "neoplasm of stomach" EXACT [MONDO:patterns/neoplasm, NCIT:C3387] +synonym: "neoplasm of the stomach" EXACT [NCIT:C3387] +synonym: "stomach neoplasm" EXACT [NCIT:C3387] +synonym: "stomach neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "stomach tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3387] +synonym: "tumor of stomach" EXACT [MONDO:patterns/neoplasm, NCIT:C3387] +synonym: "tumor of the stomach" EXACT [NCIT:C3387] +xref: EFO:0003897 {source="MONDO:equivalentTo"} +xref: MESH:D013274 {source="MONDO:equivalentTo"} +xref: NCIT:C3387 {source="MONDO:equivalentTo"} +xref: SCTID:126824007 {source="MONDO:equivalentTo"} +xref: UMLS:C0038356 {source="MONDO:equivalentTo", source="NCIT:C3387"} +is_a: MONDO:0004298 {source="MESH:D013274", source="MONDO:Redundant", source="NCIT:C3387"} ! stomach disorder +is_a: MONDO:0021223 {source="MESH:D013274", source="MONDO:Redundant", source="NCIT:C3387"} ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch http://identifiers.org/mesh/D013274 +property_value: exactMatch http://identifiers.org/snomedct/126824007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038356 +property_value: exactMatch NCIT:C3387 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021086 +name: gingival neoplasm +def: "A benign or malignant neoplasm that affects the upper or lower gingiva." [NCIT:C3057] +synonym: "gingiva neoplasm" EXACT [] +synonym: "gingiva neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "gingiva tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "gingival neoplasm" EXACT [NCIT:C3057] +synonym: "gingival tumor" EXACT [NCIT:C3057] +synonym: "gum neoplasm" EXACT [NCIT:C3057] +synonym: "gum tumor" EXACT [NCIT:C3057] +synonym: "neoplasm of gingiva" EXACT [MONDO:patterns/neoplasm, NCIT:C3057] +synonym: "neoplasm of gum" EXACT [NCIT:C3057] +synonym: "neoplasm of the gingiva" EXACT [NCIT:C3057] +synonym: "neoplasm of the gum" EXACT [NCIT:C3057] +synonym: "tumor of gingiva" EXACT [MONDO:patterns/neoplasm, NCIT:C3057] +synonym: "tumor of gum" EXACT [NCIT:C3057] +synonym: "tumor of the gingiva" EXACT [NCIT:C3057] +synonym: "tumor of the gum" EXACT [NCIT:C3057] +xref: NCIT:C3057 {source="MONDO:equivalentTo"} +xref: SCTID:126792007 {source="MONDO:equivalentTo"} +xref: UMLS:C0017570 {source="MONDO:equivalentTo", source="NCIT:C3057"} +is_a: MONDO:0002021 {source="MONDO:Redundant"} ! gingival disorder +is_a: MONDO:0021192 ! odontogenic neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001828 ! gingiva +property_value: exactMatch http://identifiers.org/snomedct/126792007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017570 +property_value: exactMatch NCIT:C3057 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021089 +name: peripheral nervous system cancer +def: "Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location" [NCIT:C4961] +synonym: "cancer of peripheral nervous system" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of peripheral nerve" EXACT [NCIT:C4961] +synonym: "malignant neoplasm of peripheral nervous system" EXACT [MONDO:patterns/cancer, NCIT:C4961] +synonym: "malignant neoplasm of PNS" EXACT [NCIT:C4961] +synonym: "malignant neoplasm of the peripheral nerve" EXACT [NCIT:C4961] +synonym: "malignant neoplasm of the peripheral nervous system" EXACT [NCIT:C4961] +synonym: "malignant neoplasm of the PNS" EXACT [NCIT:C4961] +synonym: "malignant neoplasms, peripheral nerve" EXACT [NCIT:C4961] +synonym: "malignant peripheral nerve neoplasm" EXACT [NCIT:C4961] +synonym: "malignant peripheral nerve tumor" EXACT [NCIT:C4961] +synonym: "malignant peripheral nervous system neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4961] +synonym: "malignant peripheral nervous system tumor" EXACT [NCIT:C4961] +synonym: "malignant PNS neoplasm" EXACT [NCIT:C4961] +synonym: "malignant PNS tumor" EXACT [NCIT:C4961] +synonym: "malignant tumor of peripheral nerve" EXACT [NCIT:C4961] +synonym: "malignant tumor of peripheral nervous system" EXACT [NCIT:C4961] +synonym: "malignant tumor of PNS" EXACT [NCIT:C4961] +synonym: "malignant tumor of the peripheral nerve" EXACT [NCIT:C4961] +synonym: "malignant tumor of the peripheral nervous system" EXACT [NCIT:C4961] +synonym: "malignant tumor of the PNS" EXACT [NCIT:C4961] +synonym: "peripheral nervous system cancer" EXACT [MONDO:patterns/location] +synonym: "peripheral nervous system neoplasms, malignant" EXACT [NCIT:C4961] +xref: ICD9:171.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4961 {source="MONDO:equivalentTo"} +xref: SCTID:254986007 {source="MONDO:equivalentTo"} +xref: UMLS:C0751428 {source="MONDO:equivalentTo", source="NCIT:C4961"} +is_a: MONDO:0001406 {source="MONDO:Redundant", source="NCIT:C4961"} ! peripheral nervous system neoplasm +is_a: MONDO:0005872 {source="MONDO:Redundant", source="NCIT:C4961"} ! nervous system cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000010 ! peripheral nervous system +property_value: exactMatch http://identifiers.org/snomedct/254986007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751428 +property_value: exactMatch NCIT:C4961 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021092 +name: fallopian tube neoplasm +def: "A benign or malignant neoplasm affecting the fallopian tube. Representative examples of benign neoplasms include papilloma, adenofibroma, and leiomyoma. Representative examples of malignant neoplasms include carcinoma, carcinosarcoma, and adenosarcoma." [NCIT:C3032] +synonym: "fallopian tube neoplasm" EXACT [NCIT:C3032] +synonym: "fallopian tube neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "fallopian tube tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3032] +synonym: "neoplasm of fallopian tube" EXACT [MONDO:patterns/neoplasm, NCIT:C3032] +synonym: "neoplasm of the fallopian tube" EXACT [NCIT:C3032] +synonym: "tumor of fallopian tube" EXACT [MONDO:patterns/neoplasm, NCIT:C3032] +synonym: "tumor of the fallopian tube" EXACT [NCIT:C3032] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D005185 {source="MONDO:equivalentTo"} +xref: NCIT:C3032 {source="MONDO:equivalentTo"} +xref: SCTID:126916003 {source="MONDO:equivalentTo"} +xref: UMLS:C0015558 {source="NCIT:C3032", source="MONDO:equivalentTo"} +is_a: MONDO:0002156 {source="MONDO:Redundant", source="NCIT:C3032"} ! fallopian tube disorder +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C3032"} ! female reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch http://identifiers.org/mesh/D005185 +property_value: exactMatch http://identifiers.org/snomedct/126916003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015558 +property_value: exactMatch NCIT:C3032 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021094 +name: immunodeficiency disease +def: "Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral." [NCIT:C3131-modified] +synonym: "immuno-deficiency" EXACT [NCIT:C3131] +synonym: "immunodeficiency" EXACT [NCIT:C3131] +synonym: "immunodeficiency disorder" EXACT [NCIT:C3131] +synonym: "immunodeficiency syndrome" RELATED [https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/18, NCIT:C3131] +xref: ICD9:279.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3131 {source="NCIT:C3131", source="MONDO:equivalentTo"} +xref: OMIMPS:300755 {source="MONDO:equivalentTo"} +xref: SCTID:234532001 {source="MONDO:equivalentTo"} +xref: UMLS:C0021051 {source="NCIT:C3131", source="MONDO:directSiblingOf"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005046 {source="NCIT:C3131"} ! immune system disorder +relationship: disease_has_basis_in_disruption_of GO:0002376 ! immune system process +property_value: exactMatch http://identifiers.org/snomedct/234532001 +property_value: exactMatch https://omim.org/phenotypicSeries/PS300755 +property_value: exactMatch NCIT:C3131 +property_value: excluded_subClassOf MONDO:0002254 {source="NCIT:C3131", source="https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/18"} +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0021095 +name: parkinsonian disorder +def: "A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA." [MESH:D020734] +comment: Editor note: TODO +xref: MESH:D020734 {source="MONDO:equivalentTo"} +is_a: MONDO:0003996 {source="MESH:D020734"} ! basal ganglia disorder +property_value: exactMatch http://identifiers.org/mesh/D020734 + +[Term] +id: MONDO:0021096 +name: papillary epithelial neoplasm +synonym: "papillary epithelial neoplasm" EXACT [NCIT:C8429] +xref: NCIT:C8429 {source="MONDO:equivalentTo"} +xref: UMLS:C1335324 {source="MONDO:equivalentTo", source="NCIT:C8429"} +is_a: MONDO:0005626 {source="NCIT:C8429"} ! epithelial neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335324 +property_value: exactMatch NCIT:C8429 + +[Term] +id: MONDO:0021097 +name: intraductal breast papilloma +def: "A benign papillary neoplasm that arises anywhere in the ductal system of the breast. It is characterized by fibrovascular structures lined by benign epithelial and myoepithelial proliferations. Intraductal breast papillomas are classified as central, when they arise in large ducts, or peripheral, when they arise in the terminal ductal lobular units." [NCIT:C3863] +synonym: "breast duct papilloma" RELATED [DOID:1626] +synonym: "breast papilloma" EXACT [NCIT:C3863] +synonym: "duct papilloma of breast" EXACT [DOID:1626, NCIT:C3863] +synonym: "duct papilloma of the breast" EXACT [NCIT:C3863] +synonym: "ductal breast papilloma" EXACT [NCIT:C3863] +synonym: "intraductal breast papilloma" EXACT [NCIT:C3863] +synonym: "intraductal papilloma of breast" EXACT [NCIT:C3863] +synonym: "intraductal papilloma of the breast" EXACT [NCIT:C3863] +synonym: "mammary duct papilloma" EXACT [MONDO:patterns/location] +synonym: "papilloma of breast" EXACT [NCIT:C3863] +synonym: "papilloma of the breast" EXACT [DOID:1626, NCIT:C3863] +xref: DOID:1626 {source="MONDO:equivalentTo"} +xref: EFO:1000306 {source="MONDO:equivalentTo"} +xref: NCIT:C3863 {source="MONDO:equivalentTo", source="DOID:1626", source="MONDO:directSiblingOf"} +xref: SCTID:254848002 {source="MONDO:equivalentTo", source="DOID:1626"} +xref: SCTID:99571000119102 {source="MONDO:equivalentTo"} +is_a: MONDO:0000620 {source="DOID:1626/inferred", source="MONDO:Redundant"} ! breast benign neoplasm +is_a: MONDO:0000652 ! integumentary system benign neoplasm +is_a: MONDO:0002060 {source="MONDO:Redundant", source="NCIT:C3863"} ! intraductal papilloma +is_a: MONDO:0002061 {source="DOID:1626", source="NCIT:C3863"} ! intraductal papillary breast neoplasm +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0001765 ! mammary duct +relationship: disease_has_location UBERON:0001765 ! mammary duct +property_value: exactMatch DOID:1626 +property_value: exactMatch http://identifiers.org/snomedct/254848002 +property_value: exactMatch http://identifiers.org/snomedct/99571000119102 +property_value: exactMatch NCIT:C3863 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0021100 +name: breast neoplasm +def: "A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males." [NCIT:C2910] +synonym: "breast neoplasm" EXACT [NCIT:C2910] +synonym: "breast neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "breast tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2910] +synonym: "neoplasm of breast" EXACT [MONDO:patterns/neoplasm, NCIT:C2910] +synonym: "neoplasm of the breast" EXACT [NCIT:C2910] +synonym: "neoplasm, breast" EXACT [NCIT:C2910] +synonym: "tumor of breast" EXACT [MONDO:patterns/neoplasm, NCIT:C2910] +synonym: "tumor of the breast" EXACT [NCIT:C2910] +xref: EFO:0003869 {source="MONDO:equivalentTo"} +xref: ICD9:239.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001943 {source="MONDO:equivalentTo"} +xref: NCIT:C2910 {source="MONDO:equivalentTo"} +xref: ONCOTREE:BREAST {source="MONDO:equivalentTo"} +xref: SCTID:126926005 {source="MONDO:equivalentTo"} +xref: UMLS:CN236627 {source="MONDO:equivalentTo"} +is_a: MONDO:0002657 {source="MESH:D001943", source="MONDO:Redundant", source="NCIT:C2910"} ! breast disorder +is_a: MONDO:0021350 {source="MONDO:Redundant"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000310 ! breast +property_value: exactMatch http://identifiers.org/mesh/D001943 +property_value: exactMatch http://identifiers.org/snomedct/126926005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236627 +property_value: exactMatch NCIT:C2910 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021106 +name: laminopathy +def: "A rare genetic disorder caused by mutations in genes encoding proteins of the nuclear lamina." [Wikipedia:Laminopathy] +subset: disease_grouping +subset: ordo_group_of_disorders +xref: MESH:D000083083 {source="MONDO:equivalentTo"} +xref: Orphanet:98301 {source="MONDO:equivalentTo"} +xref: UMLS:CN236383 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005652 ! nuclear lamina +relationship: disease_has_basis_in_dysfunction_of GO:0005652 ! nuclear lamina +property_value: exactMatch http://identifiers.org/mesh/D000083083 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236383 +property_value: exactMatch Orphanet:98301 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0021107 +name: narcolepsy +def: "A sleep disorder characterized by a tendency for excessive sleepiness during the day which occurs even after adequate sleep in the nighttime. The persons who suffer from this condition experience fatigue and may fall asleep at inappropriate times during the day." [NCIT:C84489] +synonym: "narcolepsy" EXACT [NCIT:C84489] +synonym: "narcolepsy, without cataplexy" NARROW [DOID:8986] +synonym: "paroxysmal sleep" EXACT [DOID:8986] +xref: DOID:8986 {source="MONDO:equivalentTo"} +xref: ICD9:347.00 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D009290 {source="DOID:8986", source="Orphanet:2073/e", source="MONDO:equivalentTo", source="Orphanet:2073"} +xref: NCIT:C84489 {source="MONDO:equivalentTo"} +xref: OMIMPS:161400 {source="MONDO:cjm", source="MONDO:equivalentTo"} +xref: SCTID:60380001 {source="MONDO:equivalentTo"} +xref: UMLS:C0027404 {source="DOID:8986", source="Orphanet:2073/e", source="MONDO:equivalentTo", source="Orphanet:2073", source="NCIT:C84489"} +is_a: MONDO:0003406 {source="DOID:8986", source="MESH:D009290/inferred", source="NCIT:C84489"} ! sleep-wake disorder +is_a: MONDO:0019117 ! genetic nervous system disorder +property_value: exactMatch DOID:8986 +property_value: exactMatch http://identifiers.org/mesh/D009290 +property_value: exactMatch http://identifiers.org/snomedct/60380001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027404 +property_value: exactMatch https://omim.org/phenotypicSeries/PS161400 +property_value: exactMatch NCIT:C84489 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml + +[Term] +id: MONDO:0021108 +name: meningitis +def: "A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord." [NCIT:C26828] +synonym: "inflammation of meninx" EXACT [] +synonym: "meningitis" EXACT [NCIT:C26828] +synonym: "meningitis (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "meninx inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: ICD9:322.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C26828 {source="MONDO:equivalentTo"} +xref: SCTID:7180009 {source="MONDO:equivalentTo"} +is_a: MONDO:0005156 ! encephalomyelitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002360 ! meninx +union_of: MONDO:0006662 ! aseptic meningitis +union_of: MONDO:0006670 ! bacterial meningitis +relationship: disease_has_inflammation_site UBERON:0002360 ! meninx +relationship: disease_has_location UBERON:0002360 {source="EFO:0000784"} ! meninx +property_value: exactMatch http://identifiers.org/snomedct/7180009 +property_value: exactMatch NCIT:C26828 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: IAO:0000589 "meningitis (disease)" xsd:string + +[Term] +id: MONDO:0021111 +name: ureter neoplasm +def: "A benign or malignant neoplasm that affects the ureter." [NCIT:C3427] +synonym: "neoplasm of the ureter" EXACT [NCIT:C3427] +synonym: "neoplasm of ureter" EXACT [MONDO:patterns/neoplasm, NCIT:C3427] +synonym: "neoplasms of the ureter" EXACT [NCIT:C3427] +synonym: "neoplasms of ureter" EXACT [NCIT:C3427] +synonym: "tumor of the ureter" EXACT [NCIT:C3427] +synonym: "tumor of ureter" EXACT [MONDO:patterns/neoplasm, NCIT:C3427] +synonym: "ureter neoplasm" EXACT [NCIT:C3427] +synonym: "ureter neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "ureter tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3427] +synonym: "ureteral neoplasm" EXACT [NCIT:C3427] +synonym: "ureteral tumor" EXACT [NCIT:C3427] +xref: EFO:0003844 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3427 {source="MONDO:equivalentTo"} +xref: SCTID:126882009 {source="MONDO:equivalentTo"} +is_a: MONDO:0001926 ! ureteral disorder +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C3427/inferred"} ! urinary system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000056 ! ureter +property_value: exactMatch http://identifiers.org/snomedct/126882009 +property_value: exactMatch NCIT:C3427 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021112 +name: scrotum cancer +def: "A primary or metastatic malignant neoplasm affecting the scrotum." [NCIT:C3560] +synonym: "cancer of scrotum" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of scrotum" EXACT [MONDO:patterns/cancer, NCIT:C3560] +synonym: "malignant neoplasm of the scrotum" EXACT [NCIT:C3560] +synonym: "malignant scrotal neoplasm" EXACT [NCIT:C3560] +synonym: "malignant scrotal tumor" EXACT [NCIT:C3560] +synonym: "malignant scrotum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant tumor of scrotum" EXACT [NCIT:C3560] +synonym: "malignant tumor of the scrotum" EXACT [NCIT:C3560] +synonym: "scrotum cancer" EXACT [MONDO:patterns/location] +xref: ICD9:187.7 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3560 {source="MONDO:equivalentTo"} +xref: SCTID:363454002 {source="MONDO:equivalentTo"} +xref: UMLS:C0153604 {source="NCIT:C3560", source="MONDO:equivalentTo"} +is_a: MONDO:0003319 {source="MONDO:Redundant", source="NCIT:C3560"} ! scrotum neoplasm +is_a: MONDO:0005836 ! male reproductive organ cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch http://identifiers.org/snomedct/363454002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153604 +property_value: exactMatch NCIT:C3560 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021114 +name: Bartholin gland neoplasm +def: "A benign or malignant neoplasm that affects the Bartholin gland. Representative examples include adenoma, adenomyoma, adenocarcinoma, and squamous cell carcinoma." [NCIT:C6434] +synonym: "Bartholin gland neoplasm" EXACT [NCIT:C6434] +synonym: "Bartholin's gland neoplasm" EXACT [NCIT:C6434] +synonym: "Bartholin's gland tumor" EXACT [NCIT:C6434] +synonym: "major vestibular gland neoplasm" EXACT [] +synonym: "major vestibular gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "major vestibular gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of Bartholin's gland" EXACT [NCIT:C6434] +synonym: "neoplasm of major vestibular gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the Bartholin's gland" EXACT [NCIT:C6434] +synonym: "tumor of Bartholin's gland" EXACT [NCIT:C6434] +synonym: "tumor of major vestibular gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Bartholin's gland" EXACT [NCIT:C6434] +xref: NCIT:C6434 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 ! integumentary system disorder +is_a: MONDO:0021049 {source="MONDO:Redundant", source="NCIT:C6434"} ! vulvar neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000460 ! major vestibular gland +relationship: disease_has_location UBERON:0000460 ! major vestibular gland +property_value: exactMatch NCIT:C6434 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021117 +name: lung neoplasm +def: "A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma." [NCIT:C3200] +synonym: "lung" RELATED [ONCOTREE:LUNG] +synonym: "lung neoplasm" EXACT [NCIT:C3200] +synonym: "lung neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "lung neoplasms" EXACT [NCIT:C3200] +synonym: "lung tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3200] +synonym: "neoplasm of lung" EXACT [MONDO:patterns/neoplasm, NCIT:C3200] +synonym: "neoplasm of the lung" EXACT [NCIT:C3200] +synonym: "neoplasm, lung" RELATED [MESH:D008175] +synonym: "neoplasm, pulmonary" RELATED [MESH:D008175] +synonym: "neoplasms, lung" RELATED [MESH:D008175] +synonym: "neoplasms, pulmonary" RELATED [MESH:D008175] +synonym: "tumor of lung" EXACT [MONDO:patterns/neoplasm, NCIT:C3200] +synonym: "tumor of the lung" EXACT [NCIT:C3200] +xref: MESH:D008175 {source="MONDO:equivalentTo"} +xref: NCIT:C3200 {source="MONDO:equivalentTo"} +xref: ONCOTREE:LUNG {source="MONDO:equivalentTo"} +is_a: MONDO:0005275 {source="MESH:D008175", source="MONDO:Redundant", source="NCIT:C3200"} ! lung disorder +is_a: MONDO:0020641 ! respiratory tract neoplasm +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C3200"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch http://identifiers.org/mesh/D008175 +property_value: exactMatch NCIT:C3200 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021118 +name: intestinal neoplasm +def: "A benign or malignant neoplasm involving the small or large intestine." [NCIT:C3141] +synonym: "bowel neoplasm" RELATED [ONCOTREE:BOWEL] +synonym: "intestinal benign neoplasm" RELATED [DOID:4610] +synonym: "intestinal neoplasm" EXACT [NCIT:C3141] +synonym: "intestinal neoplasms" EXACT [NCIT:C3141] +synonym: "intestinal tumor" EXACT [NCIT:C3141] +synonym: "intestinal tumors" EXACT [DOID:4610, NCIT:C3141] +synonym: "intestine growth" EXACT [DOID:4610] +synonym: "intestine neoplasm" EXACT [] +synonym: "intestine neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "intestine tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of intestinal tract" EXACT [DOID:4610] +synonym: "neoplasm of intestine" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of intestines" EXACT [NCIT:C3141] +synonym: "neoplasm of the intestines" EXACT [NCIT:C3141] +synonym: "tumor of intestine" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of intestines" EXACT [NCIT:C3141] +synonym: "tumor of the intestines" EXACT [NCIT:C3141] +xref: DOID:4610 {source="MONDO:equivalentTo"} +xref: NCIT:C3141 {source="DOID:4610", source="MONDO:equivalentTo"} +xref: ONCOTREE:BOWEL {source="MONDO:equivalentTo"} +xref: SCTID:126769007 {source="DOID:4610", source="MONDO:equivalentTo"} +is_a: MONDO:0005020 {source="DOID:4610", source="MONDO:Redundant", source="NCIT:C3141"} ! intestinal disorder +is_a: MONDO:0021223 {source="MONDO:Redundant", source="NCIT:C3141"} ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000160 ! intestine +property_value: exactMatch DOID:4610 +property_value: exactMatch http://identifiers.org/snomedct/126769007 +property_value: exactMatch NCIT:C3141 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021124 +name: female infertility +def: "Diminished or absent ability of a female to achieve conception." [MESH:D007247] +synonym: "female infertility" EXACT [MESH:D007247] +synonym: "female reproductive system infertility" EXACT [MONDO:patterns/location] +synonym: "female reproductive system infertility disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "female sterility" RELATED [MESH:D007247] +synonym: "female sub-fertility" RELATED [MESH:D007247] +synonym: "female subfertility" RELATED [MESH:D007247] +synonym: "infertility disorder of female reproductive system" EXACT [MONDO:design_pattern] +synonym: "postpartum sterility" RELATED [MESH:D007247] +synonym: "sterility, female" RELATED [MESH:D007247] +synonym: "sterility, postpartum" RELATED [MESH:D007247] +synonym: "sub fertility, female" RELATED [MESH:D007247] +synonym: "sub-fertility, female" RELATED [MESH:D007247] +synonym: "subfertility, female" RELATED [MESH:D007247] +xref: EFO:0008560 {source="MONDO:equivalentTo"} +xref: ICD10CM:N97 {source="MONDO:equivalentTo"} +xref: ICD9:628.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:628.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D007247 {source="MONDO:equivalentTo"} +xref: SCTID:6738008 {source="MONDO:equivalentTo"} +xref: UMLS:C0341869 {source="MONDO:equivalentTo"} +is_a: MONDO:0002263 {source="MESH:D007247/inferred", source="MONDO:Redundant"} ! female reproductive system disorder +is_a: MONDO:0005047 {source="EFO:0008560", source="MESH:D007247", source="MONDO:Entailed", source="MONDO:Redundant"} ! infertility disorder +intersection_of: MONDO:0005047 ! infertility disorder +intersection_of: disease_has_location UBERON:0000474 ! female reproductive system +property_value: exactMatch http://identifiers.org/mesh/D007247 +property_value: exactMatch http://identifiers.org/snomedct/6738008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341869 +property_value: exactMatch https://icd.codes/icd10cm/N97 + +[Term] +id: MONDO:0021125 +name: disease characteristic +def: "An attribute of a disease." [MONDO:cjm] +synonym: "disease qualifier" EXACT [] +synonym: "modifier" EXACT [NCIT:C41009] +synonym: "qualifier" EXACT [NCIT:C41009] +xref: NCIT:C41009 {source="MONDO:equivalentTo"} +is_a: PATO:0000001 ! quality +property_value: exactMatch NCIT:C41009 + +[Term] +id: MONDO:0021126 +name: syndromic or isolated +def: "An characteristic of a disease that varies depending on whether the disease appears as an isolated feature or whether the disease is a syndrome consisting of multiple features." [MONDO:cjm] +is_a: MONDO:0021125 ! disease characteristic + +[Term] +id: MONDO:0021127 +name: has a syndromic presentation +def: "An characteristic of a disease in which the disease is not manifested as an isolated feature but has multiple distinct features." [MONDO:cjm] +is_a: MONDO:0021126 ! syndromic or isolated + +[Term] +id: MONDO:0021131 +name: frontal lobe ependymal tumor +def: "An ependymal tumor affecting the frontal lobe of the brain." [NCIT:C131573] +synonym: "ependymal tumor of frontal lobe" EXACT [MONDO:design_pattern] +synonym: "frontal lobe ependymal tumor" EXACT [MONDO:patterns/location, NCIT:C131573] +xref: NCIT:C131573 {source="MONDO:equivalentTo"} +xref: UMLS:C4330009 {source="MONDO:equivalentTo"} +is_a: MONDO:0001421 {source="MONDO:Redundant", source="NCIT:C131573"} ! frontal lobe neoplasm +is_a: MONDO:0002731 ! cerebral hemisphere cancer +is_a: MONDO:0004245 {source="MONDO:Redundant", source="NCIT:C131573"} ! ependymal tumor of brain +intersection_of: MONDO:0003266 ! ependymal tumor +intersection_of: disease_has_location UBERON:0016525 ! frontal lobe +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4330009 +property_value: exactMatch NCIT:C131573 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0021135 +name: rare or common +is_a: MONDO:0021125 ! disease characteristic +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/254 xsd:anyURI + +[Term] +id: MONDO:0021136 +name: rare +def: "A disease or disorder is defined as rare in Europe when it affects fewer than 1 in 2000. A disease or disorder is defined as rare in the USA when it affects fewer than 200,000 persons at any given time. Here we take the European definition to be consistent with Orphanet." [https://www.rarediseaseday.org/article/what-is-a-rare-disease] +synonym: "rare (European definition)" EXACT [] +is_a: MONDO:0021135 ! rare or common + +[Term] +id: MONDO:0021138 +name: bone marrow cancer +def: "Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003" [NCIT:C35501] +synonym: "bone marrow cancer" EXACT [MONDO:patterns/location, NCIT:C35501] +synonym: "cancer of bone marrow" EXACT [MONDO:patterns/cancer] +synonym: "malignant bone marrow neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C35501] +synonym: "malignant bone marrow tumor" EXACT [NCIT:C35501] +synonym: "malignant neoplasm of bone marrow" EXACT [MONDO:patterns/cancer] +xref: NCIT:C35501 {source="MONDO:equivalentTo"} +xref: UMLS:C2703042 {source="MONDO:equivalentTo", source="NCIT:C35501"} +is_a: MONDO:0000621 ! immune system cancer +is_a: MONDO:0002129 ! bone cancer +is_a: MONDO:0005374 {source="MONDO:Redundant", source="NCIT:C35501"} ! bone marrow neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002371 ! bone marrow +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2703042 +property_value: exactMatch NCIT:C35501 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021139 +name: congenital or acquired +is_a: MONDO:0021125 ! disease characteristic + +[Term] +id: MONDO:0021140 +name: congenital +def: "A characteristic of a disease in which the disease is present at birth, regardless of cause." [Wikipedia:Birth_defect] +synonym: "inborn" EXACT [] +is_a: MONDO:0021139 ! congenital or acquired +relationship: has_modifier MONDO:0021140 {source="https://orcid.org/0000-0002-4142-7153"} ! congenital +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4069 + +[Term] +id: MONDO:0021141 +name: acquired +synonym: "not genetically inherited" EXACT [Orphanet:409941] +xref: Orphanet:409941 {source="MONDO:equivalentTo"} +is_a: MONDO:0021139 ! congenital or acquired +property_value: exactMatch Orphanet:409941 + +[Term] +id: MONDO:0021143 +name: melanocytic neoplasm +synonym: "melanocytic neoplasm" EXACT [NCIT:C7058] +synonym: "melanomas and nevi" RELATED [MESH:D018326] +xref: MESH:D018326 {source="MONDO:equivalentTo"} +xref: NCIT:C7058 {source="MONDO:equivalentTo"} +xref: SCTID:399956005 {source="MONDO:equivalentTo"} +xref: UMLS:C1302746 {source="NCIT:C7058", source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="MESH:D018326/inferred", source="MONDO:Redundant", source="NCIT:C7058/inferred"} ! neoplasm +is_a: MONDO:0021635 {source="MONDO:cjm"} ! neurocristopathy +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000148 ! melanocyte +relationship: disease_arises_from_structure CL:0000148 ! melanocyte +property_value: exactMatch http://identifiers.org/mesh/D018326 +property_value: exactMatch http://identifiers.org/snomedct/399956005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1302746 +property_value: exactMatch NCIT:C7058 + +[Term] +id: MONDO:0021146 +name: headache disorder +def: "Various conditions with the symptom of headache. Headache disorders are classified into major groups, such as primary headache disorders (based on characteristics of their headache symptoms) and secondary headache disorders (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)" [MESH:D020773] +synonym: "cephalgia syndrome" RELATED [MESH:D020773] +synonym: "cephalgia syndromes" RELATED [MESH:D020773] +synonym: "chronic daily headache" RELATED [MESH:D020773] +synonym: "chronic daily headaches" RELATED [MESH:D020773] +synonym: "chronic headache" RELATED [MESH:D020773] +synonym: "chronic headaches" RELATED [MESH:D020773] +synonym: "daily headache, chronic" RELATED [MESH:D020773] +synonym: "daily headaches, chronic" RELATED [MESH:D020773] +synonym: "headache disorder" EXACT [MESH:D020773] +synonym: "headache syndrome" RELATED [MESH:D020773] +synonym: "headache syndromes" RELATED [MESH:D020773] +synonym: "headache, chronic" RELATED [MESH:D020773] +synonym: "headache, chronic daily" RELATED [MESH:D020773] +synonym: "headache, intractable" RELATED [MESH:D020773] +synonym: "headaches, chronic" RELATED [MESH:D020773] +synonym: "headaches, chronic daily" RELATED [MESH:D020773] +synonym: "headaches, intractable" RELATED [MESH:D020773] +synonym: "intractable headache" RELATED [MESH:D020773] +synonym: "intractable headaches" RELATED [MESH:D020773] +synonym: "syndrome, headache" RELATED [MESH:D020773] +xref: MESH:D020773 {source="MONDO:equivalentTo"} +xref: SCTID:230461009 {source="MONDO:equivalentTo"} +is_a: MONDO:0700057 {source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-0736-9199", source="https://orcid.org/0000-0002-4142-7153", source="https://orcid.org/0000-0002-6601-2165"} ! neurological pain disorder +intersection_of: MONDO:0700057 ! neurological pain disorder +intersection_of: disease_has_major_feature HP:0002315 ! Headache +relationship: disease_has_major_feature HP:0002315 ! Headache +property_value: exactMatch http://identifiers.org/mesh/D020773 +property_value: exactMatch http://identifiers.org/snomedct/230461009 +property_value: excluded_subClassOf MONDO:0005560 {source="MESH:D020773"} + +[Term] +id: MONDO:0021147 +name: disorder of development or morphogenesis +def: "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development." [MONDO:cjm] +subset: harrisons_view +xref: ICD10CM:Q00-Q99 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0032502 ! developmental process +relationship: disease_disrupts GO:0032502 ! developmental process +property_value: exactMatch https://icd.codes/icd10cm/Q00-Q99 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0021148 +name: female reproductive system neoplasm +def: "A benign, precancerous, or malignant neoplasm that affects the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, ovarian carcinoma, cervical carcinoma, and endometrial carcinoma." [NCIT:C3053] +synonym: "female reproductive organ neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "female reproductive organ tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "female reproductive system neoplasm" EXACT [NCIT:C3053] +synonym: "female reproductive system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "female reproductive system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3053] +synonym: "gynecologic neoplasm" EXACT [NCIT:C3053] +synonym: "gynecologic tumor" EXACT [NCIT:C3053] +synonym: "neoplasm of female reproductive organ" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of female reproductive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3053] +synonym: "neoplasm of the female reproductive system" EXACT [NCIT:C3053] +synonym: "tumor of female reproductive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3053] +synonym: "tumor of the female reproductive system" EXACT [NCIT:C3053] +xref: EFO:1001331 {source="MONDO:equivalentTo"} +xref: MESH:D005833 {source="MONDO:equivalentTo"} +xref: NCIT:C3053 {source="MONDO:equivalentTo"} +xref: UMLS:C0017416 {source="NCIT:C3053", source="MONDO:equivalentTo"} +is_a: MONDO:0002263 {source="MONDO:Redundant", source="NCIT:C3053"} ! female reproductive system disorder +is_a: MONDO:0006054 {source="MONDO:Redundant", source="NCIT:C3053"} ! reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000474 ! female reproductive system +property_value: exactMatch http://identifiers.org/mesh/D005833 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0017416 +property_value: exactMatch NCIT:C3053 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021149 +name: genetic vs non-genetic etiology +is_a: MONDO:0021125 ! disease characteristic + +[Term] +id: MONDO:0021152 +name: inherited +def: "A characteristic of a disease in which the cause of the disease is a genetic problem inherited from either or both parents." [MONDO:cjm] +synonym: "constitutitional genetic" RELATED [] +synonym: "familial" RELATED [] +synonym: "genetic" RELATED [] +synonym: "hereditary" RELATED [] +synonym: "inherited genetic" RELATED [] +xref: EFO:0004420 {source="MONDO:equivalentTo"} +is_a: MONDO:0021149 ! genetic vs non-genetic etiology + +[Term] +id: MONDO:0021154 +name: dermis disorder +def: "A disease that involves the dermis." [MONDO:patterns/location] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:79381"} +synonym: "dermis disease" EXACT [MONDO:patterns/location] +synonym: "dermis disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of dermis" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of dermis" EXACT [] +synonym: "disorder of dermis" EXACT [MONDO:patterns/location_top] +synonym: "other dermis disorder" EXACT [MONDO:0019295] +xref: Orphanet:79381 {source="MONDO:equivalentTo"} +xref: UMLS:CN227618 {source="MONDO:equivalentTo"} +is_a: MONDO:0005093 {source="https://orcid.org/0000-0002-4071-8397"} ! skin disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002067 ! dermis +relationship: disease_has_location UBERON:0002067 ! dermis +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN227618 +property_value: exactMatch Orphanet:79381 +property_value: excluded_subClassOf MONDO:0019291 {source="Orphanet:79381"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0021156 +name: hypophysitis +def: "Inflammation of the pituitary gland." [MESH:D000072659] +comment: Editor note: TODO - add all subtypes; Granulomatous hypophysitis is one of five types of inflammatory hypophysitis, which are (lymphocytic, granulomatous, xanthomatous, xanthogranulomatous, and necrotizing) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494403/ +synonym: "gland, pituitary" EXACT [NCIT:C12399] +synonym: "hypophysis" EXACT [NCIT:C12399] +synonym: "hypophysis cerebri" EXACT [NCIT:C12399] +synonym: "hypophysitides" EXACT [MESH:D000072659] +synonym: "inflammation of pituitary gland" EXACT [] +synonym: "nervous system, pituitary" EXACT [NCIT:C12399] +synonym: "pituitary" EXACT [NCIT:C12399] +synonym: "pituitary gland" EXACT [NCIT:C12399] +synonym: "pituitary gland inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: MESH:D000072659 {source="MONDO:equivalentTo"} +xref: NCIT:C12399 {source="MONDO:equivalentTo"} +xref: SCTID:237705001 {source="MONDO:equivalentTo"} +xref: UMLS:C0342409 {source="MONDO:equivalentTo"} +is_a: MONDO:0003381 {source="MESH:D000072659", source="MONDO:Redundant"} ! pituitary gland disorder +is_a: MONDO:0015144 ! brain inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000007 ! pituitary gland +relationship: disease_has_inflammation_site UBERON:0000007 ! pituitary gland +property_value: exactMatch http://identifiers.org/mesh/D000072659 +property_value: exactMatch http://identifiers.org/snomedct/237705001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342409 +property_value: exactMatch NCIT:C12399 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021163 +name: kidney neoplasm +def: "A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma." [NCIT:C3150] +synonym: "kidney neoplasm" EXACT [NCIT:C3150] +synonym: "kidney neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "kidney tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3150] +synonym: "neoplasm of kidney" EXACT [MONDO:patterns/neoplasm, NCIT:C3150] +synonym: "neoplasm of the kidney" EXACT [NCIT:C3150] +synonym: "renal neoplasm" EXACT [NCIT:C3150] +synonym: "renal tumor" EXACT [NCIT:C3150] +synonym: "renal tumors" EXACT [NCIT:C3150] +synonym: "tumor of kidney" EXACT [MONDO:patterns/neoplasm, NCIT:C3150] +synonym: "tumor of the kidney" EXACT [NCIT:C3150] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3150 {source="MONDO:equivalentTo"} +xref: ONCOTREE:KIDNEY {source="MONDO:equivalentTo"} +xref: SCTID:126880001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 {source="MONDO:Redundant", source="NCIT:C3150"} ! kidney disorder +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C3150/inferred"} ! urinary system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch http://identifiers.org/snomedct/126880001 +property_value: exactMatch NCIT:C3150 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021164 +name: posthitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the prepuce of penis." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of prepuce of penis" EXACT [] +synonym: "prepuce of penis inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: SCTID:44318002 {source="MONDO:equivalentTo"} +xref: UMLS:C0235640 {source="MONDO:equivalentTo"} +is_a: MONDO:0002036 ! penile disorder +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001332 ! prepuce of penis +relationship: disease_has_inflammation_site UBERON:0001332 ! prepuce of penis +property_value: exactMatch http://identifiers.org/snomedct/44318002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235640 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021166 +name: inflammatory disease +def: "A disease involving a pathogenic inflammatory response in the anatomical structure." [MONDO:patterns/inflammatory_disease_by_site] +subset: harrisons_view +synonym: "anatomical structure inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of anatomical structure" EXACT [] +synonym: "inflammatory disease" EXACT [] +synonym: "inflammatory disorder" EXACT [] +xref: ICD9:799.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C93210 {source="MONDO:equivalentTo"} +xref: SCTID:128139000 {source="MONDO:equivalentTo"} +xref: UMLS:C1290884 {source="MONDO:equivalentTo", source="NCIT:C93210"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000061 ! anatomical structure +relationship: disease_disrupts GO:0006954 ! inflammatory response +relationship: disease_has_inflammation_site UBERON:0000061 ! anatomical structure +property_value: exactMatch http://identifiers.org/snomedct/128139000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290884 +property_value: exactMatch NCIT:C93210 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021167 +name: myositis +def: "An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of muscle tissue" EXACT [] +synonym: "inflammatory disorder of muscle" EXACT [DOID:633] +synonym: "inflammatory disorder of muscle (disorder)" EXACT [] +synonym: "muscle tissue inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: DOID:633 {source="EFO:0000783", source="MONDO:equivalentTo"} +xref: EFO:0000783 {source="MONDO:equivalentTo"} +xref: ICD9:728.9 {source="EFO:0000783"} +xref: MESH:D009220 {source="DOID:633", source="EFO:0000783", source="MONDO:equivalentTo"} +xref: NCIT:C27578 {source="DOID:633", source="EFO:0000783", source="MONDO:equivalentTo"} +xref: SCTID:128496001 {source="DOID:633", source="EFO:0000783", source="MONDO:equivalentTo"} +is_a: MONDO:0005336 {source="DOID:633"} ! myopathy +is_a: MONDO:0021166 {source="MONDO:Redundant"} ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002385 ! muscle tissue +relationship: disease_has_inflammation_site UBERON:0002385 ! muscle tissue +relationship: disease_has_location UBERON:0000383 {source="EFO:0000784"} ! musculature of body +property_value: exactMatch DOID:633 +property_value: exactMatch http://identifiers.org/mesh/D009220 +property_value: exactMatch http://identifiers.org/snomedct/128496001 +property_value: exactMatch NCIT:C27578 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021179 +name: proteostasis deficiencies +def: "Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins." [MESH:D057165] +synonym: "deficiencies, Proteostasis" EXACT [MESH:D057165] +synonym: "deficiency, Proteostasis" EXACT [MESH:D057165] +synonym: "disease, Protein folding" NARROW [MESH:D057165] +synonym: "disease, Protein Misfolding" NARROW [MESH:D057165] +synonym: "diseases, Protein folding" NARROW [MESH:D057165] +synonym: "diseases, Protein Misfolding" NARROW [MESH:D057165] +synonym: "disorder, Protein folding" NARROW [MESH:D057165] +synonym: "disorder, Protein Misfolding" NARROW [MESH:D057165] +synonym: "disorders, Protein folding" NARROW [MESH:D057165] +synonym: "disorders, Protein Misfolding" NARROW [MESH:D057165] +synonym: "dysfunction, Proteostasis" EXACT [MESH:D057165] +synonym: "dysfunctions, Proteostasis" EXACT [MESH:D057165] +synonym: "folding disease, Protein" NARROW [MESH:D057165] +synonym: "folding diseases, Protein" NARROW [MESH:D057165] +synonym: "folding disorder, Protein" NARROW [MESH:D057165] +synonym: "folding disorders, Protein" NARROW [MESH:D057165] +synonym: "Misfolding disease, Protein" NARROW [MESH:D057165] +synonym: "Misfolding diseases, Protein" NARROW [MESH:D057165] +synonym: "Misfolding disorder, Protein" NARROW [MESH:D057165] +synonym: "Misfolding disorders, Protein" NARROW [MESH:D057165] +synonym: "Protein folding disease" NARROW [MESH:D057165] +synonym: "Protein folding diseases" NARROW [MESH:D057165] +synonym: "Protein folding disorder" NARROW [MESH:D057165] +synonym: "Protein folding disorders" NARROW [MESH:D057165] +synonym: "Protein Misfolding disease" NARROW [MESH:D057165] +synonym: "Protein Misfolding diseases" NARROW [MESH:D057165] +synonym: "Protein Misfolding disorder" NARROW [MESH:D057165] +synonym: "Protein Misfolding disorders" NARROW [MESH:D057165] +synonym: "proteinopathy" RELATED [MONDO:cjm, Wikipedia:Proteopathy] +synonym: "proteopathic disease" RELATED [MONDO:cjm, Wikipedia:Proteopathy] +synonym: "proteopathy" RELATED [MONDO:cjm, Wikipedia:Proteopathy] +synonym: "Proteostasis deficiency" EXACT [MESH:D057165] +synonym: "Proteostasis dysfunction" EXACT [MESH:D057165] +synonym: "Proteostasis dysfunctions" EXACT [MESH:D057165] +xref: MESH:D057165 {source="MONDO:equivalentTo"} +xref: UMLS:C2718001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MESH:D057165"} ! metabolic disease +property_value: exactMatch http://identifiers.org/mesh/D057165 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2718001 + +[Term] +id: MONDO:0021180 +name: acquired xanthinuria +def: "Acquired xanthinuria is generally iatrogenic. Allopurinol treatment, administered to block XOR and prevent uric acid overproduction, leads to the accumulation of xanthine. Rarely, in the setting of aggressive chemotherapy with rapid tumor lysis or in patients with HPRT deficiency on allopurinol therapy, complications of renal failure can develop from xanthine crystal nephropathy." [https://www.sciencedirect.com/topics/medicine-and-dentistry/xanthinuria] +synonym: "acquired xanthinuria" EXACT [MONDO:patterns/acquired] +is_a: MONDO:0000721 ! xanthinuria +is_a: MONDO:0006504 ! acquired metabolic disease +intersection_of: MONDO:0000721 ! xanthinuria +intersection_of: has_modifier MONDO:0021141 ! acquired +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml + +[Term] +id: MONDO:0021181 +name: inherited blood coagulation disorder +def: "Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation." [MESH:D025861] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:183654"} +synonym: "coagulation disorder, hereditary" EXACT [MESH:D025861] +synonym: "coagulation disorder, inherited" EXACT [MESH:D025861] +synonym: "coagulation disorders, hereditary" EXACT [MESH:D025861] +synonym: "coagulation disorders, inherited" EXACT [MESH:D025861] +synonym: "hereditary blood coagulation disease" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary blood coagulation disorders" EXACT [MESH:D025861] +synonym: "hereditary coagulation disorder" EXACT [MESH:D025861] +synonym: "hereditary coagulation disorders" EXACT [MESH:D025861] +synonym: "inherited blood coagulation disease" RELATED [DOID:2214] +synonym: "inherited blood coagulation disorders" EXACT [MESH:D025861] +synonym: "inherited coagulation disorder" EXACT [MESH:D025861] +synonym: "inherited coagulation disorders" EXACT [MESH:D025861] +synonym: "rare genetic coagulation disorder" EXACT [Orphanet:98429] +xref: DOID:2214 {source="MONDO:equivalentObsolete"} +xref: MESH:D025861 {source="MONDO:equivalentTo", source="DOID:2214"} +xref: Orphanet:183654 {source="MONDO:equivalentTo"} +xref: UMLS:C0852077 {source="MONDO:equivalentTo", source="DOID:2214"} +xref: UMLS:CN226819 {source="MONDO:equivalentTo"} +is_a: MONDO:0001531 {source="DOID:2214", source="MESH:D025861", source="MONDO:Redundant", source="MONDO:cjm", source="MONDO:indirect"} ! blood coagulation disease +is_a: MONDO:0003847 {source="MESH:D025861", source="MONDO:Entailed", source="MONDO:Redundant"} ! Mendelian disease +intersection_of: MONDO:0001531 ! blood coagulation disease +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/D025861 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0852077 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN226819 +property_value: exactMatch Orphanet:183654 + +[Term] +id: MONDO:0021187 +name: hyperlipidemia +synonym: "hyperlipemia" RELATED [MESH:D006949] +synonym: "hyperlipemias" RELATED [MESH:D006949] +synonym: "hyperlipidemia" EXACT [MESH:D006949] +synonym: "hyperlipidemia (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "lipemia" RELATED [MESH:D006949] +synonym: "lipemias" RELATED [MESH:D006949] +synonym: "lipidemia" RELATED [MESH:D006949] +synonym: "lipidemias" RELATED [MESH:D006949] +xref: EFO:0003774 {source="MONDO:equivalentTo"} +xref: HP:0003077 {source="MONDO:otherHierarchy"} +xref: ICD10CM:E78.5 {source="MONDO:equivalentTo"} +xref: ICD9:272.4 +xref: MESH:D006949 {source="MONDO:equivalentTo"} +xref: SCTID:55822004 {source="MONDO:equivalentTo"} +xref: UMLS:C0020473 {source="MONDO:equivalentTo"} +xref: UMLS:CN236649 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="ICD10CM:E78.5/inferred", source="MESH:D006949/inferred", source="MONDO:Redundant", source="NCIT:C34709"} ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_has_major_feature HP:0003077 ! Hyperlipidemia +relationship: disease_disrupts GO:0006629 ! lipid metabolic process +relationship: disease_has_major_feature HP:0003077 ! Hyperlipidemia +property_value: exactMatch http://identifiers.org/mesh/D006949 +property_value: exactMatch http://identifiers.org/snomedct/55822004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0020473 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN236649 +property_value: exactMatch https://icd.codes/icd10cm/E78.5 +property_value: IAO:0000589 "hyperlipidemia (disease)" xsd:string + +[Term] +id: MONDO:0021190 +name: DNA repair disease +def: "A disease that has its basis in the disruption of DNA repair." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "chromosome instability syndrome" RELATED [MESH:D049914] +synonym: "chromosome instability syndromes" RELATED [MESH:D049914] +synonym: "deficiency of DNA repair" EXACT [] +synonym: "deficient DNA repair" RELATED [MESH:D049914] +synonym: "deficient DNA Repairs" RELATED [MESH:D049914] +synonym: "disorder of DNA repair" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder, DNA repair-deficiency" RELATED [MESH:D049914] +synonym: "disorders, DNA repair-deficiency" RELATED [MESH:D049914] +synonym: "DNA repair deficiency" RELATED [MESH:D049914] +synonym: "DNA repair deficiency disorders" RELATED [MESH:D049914] +synonym: "DNA repair disorder" EXACT [] +synonym: "DNA repair, deficient" RELATED [MESH:D049914] +synonym: "DNA repair-deficiencies" RELATED [MESH:D049914] +synonym: "DNA repair-deficiency" RELATED [MESH:D049914] +synonym: "DNA repair-deficiency disorder" RELATED [MESH:D049914] +synonym: "DNA Repairs, deficient" RELATED [MESH:D049914] +synonym: "repair, deficient DNA" RELATED [MESH:D049914] +synonym: "Repairs, deficient DNA" RELATED [MESH:D049914] +synonym: "syndrome, chromosome instability" RELATED [MESH:D049914] +synonym: "syndromes, chromosome instability" RELATED [MESH:D049914] +xref: EFO:0008499 {source="MONDO:equivalentTo"} +xref: MESH:D049914 {source="MONDO:equivalentTo"} +xref: NCIT:C7757 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MESH:D049914", source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006281 ! DNA repair +relationship: disease_has_basis_in_disruption_of GO:0006281 ! DNA repair +property_value: exactMatch http://identifiers.org/mesh/D049914 +property_value: exactMatch NCIT:C7757 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0021192 +name: odontogenic neoplasm +def: "A benign or malignant neoplasm arising from tooth-forming tissues. It occurs in the maxillofacial skeleton or the gingiva. Benign tumors are slow growing and are not associated with specific clinical symptoms. Pain is absent or slight. Malignant tumors are usually associated with rapid swelling and pain." [NCIT:C3286] +synonym: "calcareous tooth neoplasm" EXACT [] +synonym: "calcareous tooth neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "calcareous tooth tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of calcareous tooth" EXACT [MONDO:patterns/neoplasm] +synonym: "odontogenic neoplasm" EXACT [NCIT:C3286] +synonym: "odontogenic tumor" EXACT [NCIT:C3286] +synonym: "tumor of calcareous tooth" EXACT [MONDO:patterns/neoplasm] +xref: ICDO:9270/1 {source="NCIT:C3286"} +xref: MESH:D009808 {source="MONDO:equivalentTo"} +xref: NCIT:C3286 {source="MONDO:equivalentTo"} +xref: UMLS:C0028880 {source="NCIT:C3286", source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3286/inferred"} ! head and neck neoplasm +is_a: MONDO:0006999 {source="MONDO:Redundant", source="NCIT:C3286"} ! tooth disorder +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001091 ! calcareous tooth +property_value: exactMatch http://identifiers.org/mesh/D009808 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0028880 +property_value: exactMatch NCIT:C3286 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021193 +name: neuroepithelial neoplasm +def: "A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors." [NCIT:C3787] +comment: Editor note consider adding grouping class for Neuroepithelial, Perineurial, and Schwann Cell Neoplasm +synonym: "neoplasm of neuroepithelial tissue" EXACT [NCIT:C3787] +synonym: "neoplasm of neuroepithelium" EXACT [NCIT:C3787] +synonym: "neoplasm of the neuroepithelium" EXACT [NCIT:C3787] +synonym: "neuroepithelial neoplasm" EXACT [NCIT:C3787] +synonym: "neuroepithelial neoplasms" EXACT [NCIT:C3787] +synonym: "neuroepithelial tissue neoplasm" EXACT [NCIT:C3787] +synonym: "neuroepithelial tissue tumor" EXACT [NCIT:C3787] +synonym: "neuroepithelial tumor" EXACT [NCIT:C3787] +synonym: "neuroepithelial tumors" EXACT [NCIT:C3787] +synonym: "primary neuroepithelial tumor" RELATED [ONCOTREE:PRNET] +synonym: "tumor of neuroepithelial tissue" EXACT [NCIT:C3787] +synonym: "tumor of neuroepithelium" EXACT [NCIT:C3787] +synonym: "tumor of the neuroepithelium" EXACT [NCIT:C3787] +xref: MESH:D018302 {source="MONDO:equivalentTo"} +xref: NCIT:C3787 {source="MONDO:equivalentTo"} +xref: ONCOTREE:PRNET {source="MONDO:equivalentTo"} +is_a: MONDO:0021248 {source="NCIT:C35562", source="NCIT:C3787/inferred"} ! nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure UBERON:0034705 ! developing neuroepithelium +relationship: disease_arises_from_structure UBERON:0034705 ! developing neuroepithelium +property_value: exactMatch http://identifiers.org/mesh/D018302 +property_value: exactMatch NCIT:C3787 + +[Term] +id: MONDO:0021201 +name: skin infection +def: "An inflammatory process affecting the skin, caused by bacteria, viruses, parasites, or fungi. Examples of bacterial infection include carbuncles, furuncles, impetigo, erysipelas, and abscesses. Examples of viral infection include shingles, warts, molluscum contagiosum, and pityriasis rosea. Examples of parasitic infection include scabies and lice. Examples of fungal infection include athlete's foot, yeast infection, and ringworm." [NCIT:C35025] +synonym: "skin infection" EXACT [NCIT:C35025] +xref: NCIT:C35025 {source="MONDO:equivalentTo"} +xref: SCTID:19824006 {source="MONDO:equivalentTo"} +xref: UMLS:C0037278 {source="MONDO:equivalentTo", source="NCIT:C35025"} +is_a: MONDO:0002406 ! dermatitis +is_a: MONDO:0024294 ! skin disorder caused by infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0000014 ! zone of skin +property_value: exactMatch http://identifiers.org/snomedct/19824006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037278 +property_value: exactMatch NCIT:C35025 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021202 +name: allergic otitis media +def: "A otitis media (disease) with a basis in a pathological type I hypersensitivity reaction." [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic form of otitis media (disease)" EXACT [MONDO:patterns/allergic_form_of_disease] +synonym: "allergic otitis media (disease)" EXACT [] +xref: SCTID:26169004 {source="MONDO:equivalentTo"} +xref: UMLS:C0271447 {source="MONDO:equivalentTo"} +is_a: MONDO:0005271 ! allergic disease +is_a: MONDO:0005441 {source="MONDO:Redundant"} ! otitis media +intersection_of: MONDO:0005441 ! otitis media +intersection_of: disease_has_basis_in_disruption_of GO:0016068 ! type I hypersensitivity +property_value: exactMatch http://identifiers.org/snomedct/26169004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271447 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/allergic_form_of_disease.yaml + +[Term] +id: MONDO:0021204 +name: chronic otitis media +def: "Chronic form of otitis media (disease)." [MONDO:patterns/chronic] +synonym: "chronic otitis media (disease)" EXACT [] +synonym: "otitis media (disease), chronic" EXACT [MONDO:patterns/chronic] +xref: ICD9:381.3 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:21186006 {source="MONDO:equivalentTo"} +xref: UMLS:C0271441 {source="MONDO:equivalentTo"} +is_a: MONDO:0005441 {source="MONDO:Redundant"} ! otitis media +intersection_of: MONDO:0005441 ! otitis media +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/21186006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271441 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/chronic.yaml + +[Term] +id: MONDO:0021205 +name: disorder of ear +def: "A disease that involves the ear." [MONDO:patterns/location] +synonym: "disease of ear" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ear" EXACT [] +synonym: "disorder of ear" EXACT [MONDO:patterns/location_top] +synonym: "Ear disease" EXACT [NCIT:C26757] +synonym: "ear disease" EXACT [MONDO:patterns/location] +synonym: "ear disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "Ear disorder" EXACT [NCIT:C26757] +xref: ICD9:388.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:388.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C26757 {source="MONDO:equivalentTo"} +xref: SCTID:25906001 {source="MONDO:equivalentTo"} +xref: UMLS:C0013447 {source="MONDO:equivalentTo", source="NCIT:C26757"} +is_a: MONDO:0005042 ! head disorder +is_a: MONDO:0024623 {source="MONDO:cjm", source="NCIT:C26757"} ! otorhinolaryngologic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001690 ! ear +relationship: disease_has_location UBERON:0001690 ! ear +property_value: exactMatch http://identifiers.org/snomedct/25906001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0013447 +property_value: exactMatch NCIT:C26757 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0021209 +name: heart neoplasm +def: "A neoplasm (disease) that involves the heart." [MONDO:patterns/location] +subset: gard_rare +synonym: "Cardiac neoplasm" EXACT [NCIT:C3081] +synonym: "Cardiac neoplasms" EXACT [NCIT:C3081] +synonym: "Cardiac tumor" EXACT [NCIT:C3081] +synonym: "heart neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "heart tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3081] +synonym: "Intracavitary tumors" RELATED [GARD:0002619] +synonym: "myocardial tumors (rhabdomyomas and fibromas)" RELATED [GARD:0002619] +synonym: "neoplasm of heart" EXACT [MONDO:patterns/neoplasm, NCIT:C3081] +synonym: "neoplasm of the heart" EXACT [NCIT:C3081] +synonym: "primary cardiac tumors, childhood" RELATED [GARD:0002619] +synonym: "tumor of heart" EXACT [MONDO:patterns/neoplasm, NCIT:C3081] +synonym: "tumor of the heart" EXACT [NCIT:C3081] +xref: EFO:1001339 {source="MONDO:equivalentTo"} +xref: GARD:0002619 {source="MONDO:equivalentTo"} +xref: NCIT:C3081 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 {source="MONDO:Redundant", source="NCIT:C3081"} ! heart disorder +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C3081"} ! neoplasm of thorax +is_a: MONDO:0024757 ! cardiovascular neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000948 ! heart +relationship: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch NCIT:C3081 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021210 +name: trachea neoplasm +def: "A neoplasm (disease) that involves the trachea." [MONDO:patterns/location] +synonym: "neoplasm of the trachea" EXACT [NCIT:C3419] +synonym: "neoplasm of trachea" EXACT [MONDO:patterns/neoplasm, NCIT:C3419] +synonym: "trachea neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "trachea tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3419] +synonym: "tracheal neoplasm" EXACT [NCIT:C3419] +synonym: "tracheal tumor" EXACT [NCIT:C3419] +synonym: "tumor of the trachea" EXACT [NCIT:C3419] +synonym: "tumor of trachea" EXACT [MONDO:patterns/neoplasm, NCIT:C3419] +xref: EFO:1001437 {source="MONDO:equivalentTo"} +xref: GTR:AN0481062 {source="UMLS:C0040582"} +xref: GTR:AN0505660 {source="UMLS:C0040582"} +xref: HP:0100551 {xref="UMLS:C0040582", source="UMLS:C0040582"} +xref: MESH:D014134 {source="MONDO:equivalentTo", source="UMLS:C0040582"} +xref: NCIT:C3419 {source="MONDO:equivalentTo", source="UMLS:C0040582"} +xref: UMLS:C0040582 {source="NCIT:C3419", source="MONDO:equivalentTo"} +is_a: MONDO:0002567 {source="MONDO:Redundant", source="NCIT:C3419"} ! tracheal disorder +is_a: MONDO:0020641 ! respiratory tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch http://identifiers.org/mesh/D014134 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040582 +property_value: exactMatch NCIT:C3419 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021211 +name: brain neoplasm +def: "A neoplasm (disease) that involves the brain." [MONDO:patterns/location] +synonym: "brain neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "brain neoplasms" EXACT [NCIT:C2907] +synonym: "brain tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2907] +synonym: "neoplasm of brain" EXACT [MONDO:patterns/neoplasm, NCIT:C2907] +synonym: "neoplasm of the brain" EXACT [NCIT:C2907] +synonym: "tumor of brain" EXACT [MONDO:patterns/neoplasm, NCIT:C2907] +synonym: "tumor of the Brain" EXACT [NCIT:C2907] +xref: NCIT:C2907 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 ! brain disorder +is_a: MONDO:0006130 {source="MONDO:Redundant", source="NCIT:C2907/inferred"} ! central nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch NCIT:C2907 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021218 +name: placenta neoplasm +def: "A neoplasm (disease) that involves the placenta." [MONDO:patterns/location] +synonym: "neoplasm of placenta" EXACT [MONDO:patterns/neoplasm, NCIT:C4858] +synonym: "neoplasm of the placenta" EXACT [NCIT:C4858] +synonym: "placenta neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "placenta neoplasms" EXACT [NCIT:C4858] +synonym: "placenta tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4858] +synonym: "placenta tumors" EXACT [NCIT:C4858] +synonym: "placental neoplasm" EXACT [NCIT:C4858] +synonym: "placental tumor" EXACT [NCIT:C4858] +synonym: "placental tumors" EXACT [NCIT:C4858] +synonym: "trophoblastic tumor placental site" RELATED [GARD:0007403] +synonym: "tumor of placenta" EXACT [MONDO:patterns/neoplasm, NCIT:C4858] +synonym: "tumor of the placenta" EXACT [NCIT:C4858] +xref: GARD:0007403 {source="MONDO:equivalentTo"} +xref: NCIT:C4858 {source="MONDO:equivalentTo"} +is_a: MONDO:0005917 {source="MONDO:Redundant", source="NCIT:C4858"} ! placenta disorder +is_a: MONDO:0021353 ! tumor of uterus +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001987 ! placenta +property_value: exactMatch NCIT:C4858 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021220 +name: eye neoplasm +def: "A neoplasm (disease) that involves the eye." [MONDO:patterns/location] +synonym: "eye neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "eye tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3030] +synonym: "eyeball of camera-type eye neoplasm" EXACT [] +synonym: "eyeball of camera-type eye tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of eye" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of eyeball of camera-type eye" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the eye" EXACT [NCIT:C3030] +synonym: "ocular neoplasm" EXACT [NCIT:C3030] +synonym: "ocular tumor" EXACT [NCIT:C3030] +synonym: "tumor of eye" EXACT [MONDO:patterns/neoplasm, NCIT:C3030] +synonym: "tumor of eyeball of camera-type eye" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the eye" EXACT [NCIT:C3030] +xref: NCIT:C3030 {source="MONDO:equivalentTo"} +xref: ONCOTREE:EYE {source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="MONDO:Redundant", source="NCIT:C3030"} ! eye disorder +is_a: MONDO:0005586 ! head and neck neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch NCIT:C3030 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021221 +name: vestibulocochlear nerve neoplasm +def: "A neoplasm (disease) that involves the vestibulocochlear nerve." [MONDO:patterns/location] +synonym: "acoustic nerve neoplasm" EXACT [NCIT:C5120] +synonym: "acoustic nerve tumor" EXACT [NCIT:C5120] +synonym: "cranial nerve eight neoplasms" EXACT [NCIT:C5120] +synonym: "eighth cranial nerve neoplasm" EXACT [NCIT:C5120] +synonym: "eighth cranial nerve neoplasms" EXACT [NCIT:C5120] +synonym: "eighth cranial nerve tumor" EXACT [NCIT:C5120] +synonym: "neoplasm of acoustic nerve" EXACT [NCIT:C5120] +synonym: "neoplasm of eighth cranial nerve" EXACT [NCIT:C5120] +synonym: "neoplasm of the acoustic nerve" EXACT [NCIT:C5120] +synonym: "neoplasm of the eighth cranial nerve" EXACT [NCIT:C5120] +synonym: "neoplasm of the vestibulocochlear nerve" EXACT [NCIT:C5120] +synonym: "neoplasm of vestibulocochlear nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5120] +synonym: "tumor of acoustic nerve" EXACT [NCIT:C5120] +synonym: "tumor of eighth cranial nerve" EXACT [NCIT:C5120] +synonym: "tumor of the acoustic nerve" EXACT [NCIT:C5120] +synonym: "tumor of the eighth cranial nerve" EXACT [NCIT:C5120] +synonym: "tumor of the vestibulocochlear nerve" EXACT [NCIT:C5120] +synonym: "tumor of vestibulocochlear nerve" EXACT [MONDO:patterns/neoplasm, NCIT:C5120] +synonym: "Vestibuloacoustic nerve neoplasms" EXACT [NCIT:C5120] +synonym: "vestibulocochlear nerve neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "vestibulocochlear nerve neoplasms" EXACT [NCIT:C5120] +synonym: "vestibulocochlear nerve tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5120] +xref: NCIT:C5120 {source="MONDO:equivalentTo"} +xref: SCTID:387891008 {source="MONDO:equivalentTo"} +xref: UMLS:C0346330 {source="NCIT:C5120", source="MONDO:equivalentTo"} +is_a: MONDO:0001563 ! vestibulocochlear nerve disorder +is_a: MONDO:0002633 {source="MONDO:Redundant", source="NCIT:C5120"} ! cranial nerve neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001648 ! vestibulocochlear nerve +property_value: exactMatch http://identifiers.org/snomedct/387891008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346330 +property_value: exactMatch NCIT:C5120 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021222 +name: lacrimal gland neoplasm +def: "A neoplasm (disease) that involves the lacrimal gland." [MONDO:patterns/location] +synonym: "lacrimal gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "lacrimal gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4360] +synonym: "neoplasm of lacrimal gland" EXACT [MONDO:patterns/neoplasm, NCIT:C4360] +synonym: "neoplasm of the lacrimal gland" EXACT [NCIT:C4360] +synonym: "tumor of lacrimal gland" EXACT [MONDO:patterns/neoplasm, NCIT:C4360] +synonym: "tumor of the lacrimal gland" EXACT [NCIT:C4360] +xref: NCIT:C4360 {source="MONDO:equivalentTo"} +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C4360/inferred"} ! eye neoplasm +is_a: MONDO:0024625 ! disorder of lacrimal gland +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch NCIT:C4360 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021223 +name: digestive system neoplasm +def: "A neoplasm (disease) that involves the digestive system." [MONDO:patterns/location] +synonym: "digestive neoplasm" EXACT [NCIT:C3052] +synonym: "digestive system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "digestive system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3052] +synonym: "digestive tumor" EXACT [NCIT:C3052] +synonym: "gastrointestinal neoplasm" EXACT [NCIT:C3052] +synonym: "gastrointestinal system neoplasm" EXACT [NCIT:C3052] +synonym: "gastrointestinal system tumor" EXACT [NCIT:C3052] +synonym: "gastrointestinal tumor" EXACT [NCIT:C3052] +synonym: "GI neoplasm" EXACT [NCIT:C3052] +synonym: "GI system neoplasm" EXACT [NCIT:C3052] +synonym: "GI system tumor" EXACT [NCIT:C3052] +synonym: "GI tumor" EXACT [NCIT:C3052] +synonym: "neoplasm of digestive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3052] +synonym: "neoplasm of gastrointestinal system" EXACT [NCIT:C3052] +synonym: "neoplasm of GI system" EXACT [NCIT:C3052] +synonym: "neoplasm of the digestive system" EXACT [NCIT:C3052] +synonym: "neoplasm of the gastrointestinal system" EXACT [NCIT:C3052] +synonym: "neoplasm of the GI system" EXACT [NCIT:C3052] +synonym: "tumor of digestive system" EXACT [MONDO:patterns/neoplasm, NCIT:C3052] +synonym: "tumor of gastrointestinal system" EXACT [NCIT:C3052] +synonym: "tumor of GI system" EXACT [NCIT:C3052] +synonym: "tumor of the digestive system" EXACT [NCIT:C3052] +synonym: "tumor of the gastrointestinal system" EXACT [NCIT:C3052] +synonym: "tumor of the GI system" EXACT [NCIT:C3052] +xref: EFO:0008549 {source="MONDO:equivalentTo"} +xref: MESH:D005770 {source="MONDO:equivalentTo"} +xref: NCIT:C3052 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="EFO:0008549", source="MESH:D005770/inferred", source="MONDO:Redundant", source="NCIT:C3052/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001007 ! digestive system +relationship: disease_has_location UBERON:0001007 ! digestive system +property_value: exactMatch http://identifiers.org/mesh/D005770 +property_value: exactMatch NCIT:C3052 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021224 +name: iris neoplasm +def: "A neoplasm (disease) that involves the iris." [MONDO:patterns/location] +synonym: "iris neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "iris tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3142] +synonym: "neoplasm of iris" EXACT [MONDO:patterns/neoplasm, NCIT:C3142] +synonym: "neoplasm of the iris" EXACT [NCIT:C3142] +synonym: "tumor of iris" EXACT [MONDO:patterns/neoplasm, NCIT:C3142] +synonym: "tumor of the iris" EXACT [NCIT:C3142] +xref: MESH:D015811 {source="MONDO:equivalentTo"} +xref: NCIT:C3142 {source="MONDO:equivalentTo"} +xref: UMLS:C0022079 {source="NCIT:C3142", source="MONDO:equivalentTo"} +is_a: MONDO:0002289 ! iris disorder +is_a: MONDO:0021225 {source="MONDO:Redundant", source="NCIT:C3142"} ! uvea neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001769 ! iris +property_value: exactMatch http://identifiers.org/mesh/D015811 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022079 +property_value: exactMatch NCIT:C3142 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021225 +name: uvea neoplasm +def: "A neoplasm (disease) that involves the uvea." [MONDO:patterns/location] +synonym: "neoplasm of the uvea" EXACT [NCIT:C3436] +synonym: "neoplasm of uvea" EXACT [MONDO:patterns/neoplasm, NCIT:C3436] +synonym: "tumor of the uvea" EXACT [NCIT:C3436] +synonym: "tumor of uvea" EXACT [MONDO:patterns/neoplasm, NCIT:C3436] +synonym: "uvea neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "uvea tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3436] +synonym: "uveal neoplasm" EXACT [NCIT:C3436] +synonym: "uveal tumor" EXACT [NCIT:C3436] +xref: NCIT:C3436 {source="MONDO:equivalentTo"} +xref: UMLS:C0042162 {source="MONDO:equivalentTo", source="NCIT:C3436"} +is_a: MONDO:0002661 {source="MONDO:Redundant", source="NCIT:C3436"} ! uveal disorder +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C3436"} ! eye neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001768 ! uvea +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042162 +property_value: exactMatch NCIT:C3436 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021227 +name: adrenal gland neoplasm +def: "A neoplasm (disease) that involves the adrenal gland." [MONDO:patterns/location] +synonym: "adrenal gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "adrenal gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2859] +synonym: "adrenal neoplasm" EXACT [NCIT:C2859] +synonym: "adrenal neoplasms" EXACT [NCIT:C2859] +synonym: "adrenal tumor" EXACT [NCIT:C2859] +synonym: "ADRENALGLAND" RELATED ABBREVIATION [ONCOTREE:ADRENALGLAND] +synonym: "neoplasm of adrenal gland" EXACT [MONDO:patterns/neoplasm, NCIT:C2859] +synonym: "neoplasm of the adrenal gland" EXACT [NCIT:C2859] +synonym: "tumor of adrenal gland" EXACT [MONDO:patterns/neoplasm, NCIT:C2859] +synonym: "tumor of the adrenal gland" EXACT [NCIT:C2859] +xref: EFO:0003850 {source="MONDO:equivalentTo"} +xref: NCIT:C2859 {source="MONDO:equivalentTo"} +xref: ONCOTREE:ADRENALGLAND {source="MONDO:equivalentTo"} +is_a: MONDO:0002082 ! endocrine gland neoplasm +is_a: MONDO:0005495 {source="MONDO:Redundant", source="NCIT:C2859"} ! adrenal gland disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +property_value: exactMatch NCIT:C2859 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021228 +name: brainstem neoplasm +def: "A neoplasm (disease) that involves the brainstem." [MONDO:patterns/location] +synonym: "Brain stem neoplasm" EXACT [NCIT:C4869] +synonym: "brain stem tumor" EXACT [NCIT:C4869] +synonym: "brainstem neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "brainstem tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4869] +synonym: "neoplasm of brain stem" EXACT [NCIT:C4869] +synonym: "neoplasm of brainstem" EXACT [MONDO:patterns/neoplasm, NCIT:C4869] +synonym: "neoplasm of the brain stem" EXACT [NCIT:C4869] +synonym: "neoplasm of the brainstem" EXACT [NCIT:C4869] +synonym: "tumor of brain stem" EXACT [NCIT:C4869] +synonym: "tumor of brainstem" EXACT [MONDO:patterns/neoplasm, NCIT:C4869] +synonym: "tumor of the brain stem" EXACT [NCIT:C4869] +synonym: "tumor of the brainstem" EXACT [NCIT:C4869] +xref: NCIT:C4869 {source="MONDO:equivalentTo"} +xref: Orphanet:36414 {source="MONDO:equivalentTo"} +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C4869/inferred"} ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002298 ! brainstem +relationship: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch NCIT:C4869 +property_value: exactMatch Orphanet:36414 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021229 +name: ciliary body neoplasm +def: "A neoplasm (disease) that involves the ciliary body." [MONDO:patterns/location] +synonym: "ciliary body neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "ciliary body tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4364] +synonym: "neoplasm of ciliary body" EXACT [MONDO:patterns/neoplasm, NCIT:C4364] +synonym: "neoplasm of the ciliary body" EXACT [NCIT:C4364] +synonym: "tumor of ciliary body" EXACT [MONDO:patterns/neoplasm, NCIT:C4364] +synonym: "tumor of the ciliary body" EXACT [NCIT:C4364] +xref: NCIT:C4364 {source="MONDO:equivalentTo"} +xref: UMLS:C0339349 {source="NCIT:C4364", source="MONDO:equivalentTo"} +is_a: MONDO:0002970 {source="MONDO:Redundant", source="NCIT:C4364"} ! ciliary body disorder +is_a: MONDO:0021224 ! iris neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001775 ! ciliary body +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339349 +property_value: exactMatch NCIT:C4364 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021230 +name: uterine cervix neoplasm +def: "A neoplasm (disease) that involves the uterine cervix." [MONDO:patterns/location] +synonym: "Cervical neoplasm" EXACT [NCIT:C2940] +synonym: "cervical tumor" EXACT [NCIT:C2940] +synonym: "cervix" RELATED [ONCOTREE:CERVIX] +synonym: "cervix neoplasm" EXACT [NCIT:C2940] +synonym: "cervix tumor" EXACT [NCIT:C2940] +synonym: "cervix uteri neoplasm" EXACT [NCIT:C2940] +synonym: "cervix uteri tumor" EXACT [NCIT:C2940] +synonym: "neoplasm of cervix" EXACT [NCIT:C2940] +synonym: "neoplasm of cervix uteri" EXACT [NCIT:C2940] +synonym: "neoplasm of the cervix" EXACT [NCIT:C2940] +synonym: "neoplasm of the cervix uteri" EXACT [NCIT:C2940] +synonym: "neoplasm of the uterine cervix" EXACT [NCIT:C2940] +synonym: "neoplasm of uterine cervix" EXACT [MONDO:patterns/neoplasm, NCIT:C2940] +synonym: "tumor of cervix" EXACT [NCIT:C2940] +synonym: "tumor of cervix uteri" EXACT [NCIT:C2940] +synonym: "tumor of the cervix" EXACT [NCIT:C2940] +synonym: "tumor of the cervix uteri" EXACT [NCIT:C2940] +synonym: "tumor of the uterine cervix" EXACT [NCIT:C2940] +synonym: "tumor of uterine cervix" EXACT [MONDO:patterns/neoplasm, NCIT:C2940] +synonym: "uterine cervix neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "uterine cervix tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2940] +xref: NCIT:C2940 {source="MONDO:equivalentTo"} +xref: ONCOTREE:CERVIX {source="MONDO:equivalentTo"} +is_a: MONDO:0002256 ! cervix disorder +is_a: MONDO:0021353 {source="MONDO:Redundant", source="NCIT:C2940"} ! tumor of uterus +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000002 ! uterine cervix +property_value: exactMatch NCIT:C2940 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021231 +name: retina neoplasm +def: "A neoplasm (disease) that involves the retina." [MONDO:patterns/location] +synonym: "neoplasm of retina" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the retina" EXACT [NCIT:C4800] +synonym: "retina neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "retina tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4800] +synonym: "retinal neoplasm" EXACT [NCIT:C4800] +synonym: "retinal tumor" EXACT [NCIT:C4800] +synonym: "tumor of retina" EXACT [MONDO:patterns/neoplasm, NCIT:C4800] +synonym: "tumor of the retina" EXACT [NCIT:C4800] +xref: EFO:1000509 {source="MONDO:equivalentTo"} +xref: NCIT:C4800 {source="MONDO:equivalentTo"} +is_a: MONDO:0005283 ! retinal disorder +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C4800"} ! eye neoplasm +is_a: MONDO:0021248 ! nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch NCIT:C4800 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021232 +name: pineal body neoplasm +def: "A neoplasm (disease) that involves the pineal body." [MONDO:patterns/location] +synonym: "neoplasm of pineal area" EXACT [NCIT:C3328] +synonym: "neoplasm of pineal body" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of pineal region" EXACT [NCIT:C3328] +synonym: "neoplasm of the pineal area" EXACT [NCIT:C3328] +synonym: "neoplasm of the pineal region" EXACT [NCIT:C3328] +synonym: "pineal area neoplasm" EXACT [NCIT:C3328] +synonym: "pineal area tumor" EXACT [NCIT:C3328] +synonym: "pineal body neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pineal body tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3328] +synonym: "pineal neoplasm" EXACT [NCIT:C3328] +synonym: "pineal region neoplasm" EXACT [NCIT:C3328] +synonym: "pineal region tumor" EXACT [NCIT:C3328] +synonym: "pineal tumor" EXACT [NCIT:C3328] +synonym: "pinealoma" EXACT [NCIT:C3328] +synonym: "tumor of pineal area" EXACT [NCIT:C3328] +synonym: "tumor of pineal body" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of pineal region" EXACT [NCIT:C3328] +synonym: "tumor of the pineal area" EXACT [NCIT:C3328] +synonym: "tumor of the pineal region" EXACT [NCIT:C3328] +xref: NCIT:C3328 {source="MONDO:equivalentTo"} +xref: ONCOTREE:PINT {source="MONDO:equivalentTo"} +is_a: MONDO:0002082 ! endocrine gland neoplasm +is_a: MONDO:0003081 ! thalamic disorder +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C3328/inferred"} ! brain neoplasm +is_a: MONDO:0100070 ! neuroendocrine disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001905 ! pineal body +relationship: disease_has_location UBERON:0001905 ! pineal body +property_value: exactMatch NCIT:C3328 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021233 +name: ear neoplasm +def: "A neoplasm (disease) that involves the ear." [MONDO:patterns/location] +synonym: "ear neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "Ear neoplasms" EXACT [NCIT:C3000] +synonym: "Ear tumor" EXACT [NCIT:C3000] +synonym: "ear tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of Ear" EXACT [NCIT:C3000] +synonym: "neoplasm of ear" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the Ear" EXACT [NCIT:C3000] +synonym: "tumor of Ear" EXACT [NCIT:C3000] +synonym: "tumor of ear" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Ear" EXACT [NCIT:C3000] +xref: NCIT:C3000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3000"} ! head and neck neoplasm +is_a: MONDO:0021205 {source="MONDO:Redundant", source="NCIT:C3000"} ! disorder of ear +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001690 ! ear +property_value: exactMatch NCIT:C3000 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021234 +name: spinal cord neoplasm +def: "A neoplasm (disease) that involves the spinal cord." [MONDO:patterns/location] +synonym: "neoplasm of spinal cord" EXACT [MONDO:patterns/neoplasm, NCIT:C3381] +synonym: "neoplasm of the spinal cord" EXACT [NCIT:C3381] +synonym: "spinal cord neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "spinal cord tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3381] +synonym: "tumor of spinal cord" EXACT [MONDO:patterns/neoplasm, NCIT:C3381] +synonym: "tumor of the spinal cord" EXACT [NCIT:C3381] +xref: MESH:D013120 {source="MONDO:equivalentTo"} +xref: NCIT:C3381 {source="MONDO:equivalentTo"} +xref: UMLS:C0037930 {source="NCIT:C3381", source="MONDO:equivalentTo"} +is_a: MONDO:0002545 ! spinal cord disorder +is_a: MONDO:0006130 {source="MONDO:Redundant", source="NCIT:C3381/inferred"} ! central nervous system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch http://identifiers.org/mesh/D013120 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037930 +property_value: exactMatch NCIT:C3381 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021235 +name: external ear neoplasm +def: "A neoplasm (disease) that involves the external ear." [MONDO:patterns/location] +synonym: "external ear neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "external Ear tumor" EXACT [NCIT:C4652] +synonym: "external ear tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of external Ear" EXACT [NCIT:C4652] +synonym: "neoplasm of external ear" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the external Ear" EXACT [NCIT:C4652] +synonym: "tumor of external Ear" EXACT [NCIT:C4652] +synonym: "tumor of external ear" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the external Ear" EXACT [NCIT:C4652] +xref: NCIT:C4652 {source="MONDO:equivalentTo"} +xref: SCTID:277155005 {source="MONDO:equivalentTo"} +xref: UMLS:C0349575 {source="MONDO:equivalentTo", source="NCIT:C4652"} +is_a: MONDO:0002776 ! external ear disorder +is_a: MONDO:0021233 {source="MONDO:Redundant", source="NCIT:C4652"} ! ear neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001691 ! external ear +property_value: exactMatch http://identifiers.org/snomedct/277155005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349575 +property_value: exactMatch NCIT:C4652 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021237 +name: adrenal medulla neoplasm +def: "A neoplasm (disease) that involves the adrenal medulla." [MONDO:patterns/location] +synonym: "adrenal medulla neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "adrenal medulla tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of adrenal medulla" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of adrenal medulla" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C4856 {source="MONDO:equivalentTo"} +xref: UMLS:C0596046 {source="MONDO:equivalentTo", source="NCIT:C4856"} +is_a: MONDO:0021227 {source="MONDO:Redundant", source="NCIT:C4856"} ! adrenal gland neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001236 ! adrenal medulla +relationship: disease_has_location UBERON:0001236 ! adrenal medulla +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0596046 +property_value: exactMatch NCIT:C4856 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021238 +name: cornea neoplasm +def: "A neoplasm (disease) that involves the cornea." [MONDO:patterns/location] +synonym: "cornea neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "cornea tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4361] +synonym: "corneal neoplasm" EXACT [NCIT:C4361] +synonym: "corneal tumor" EXACT [NCIT:C4361] +synonym: "neoplasm of cornea" EXACT [MONDO:patterns/neoplasm, NCIT:C4361] +synonym: "neoplasm of the cornea" EXACT [NCIT:C4361] +synonym: "tumor of cornea" EXACT [MONDO:patterns/neoplasm, NCIT:C4361] +synonym: "tumor of the cornea" EXACT [NCIT:C4361] +xref: NCIT:C4361 {source="MONDO:equivalentTo"} +xref: UMLS:C0339304 {source="NCIT:C4361", source="MONDO:equivalentTo"} +is_a: MONDO:0000942 {source="MONDO:Redundant", source="NCIT:C4361"} ! corneal disorder +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C4361"} ! eye neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339304 +property_value: exactMatch NCIT:C4361 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021239 +name: urethra neoplasm +def: "A neoplasm (disease) that involves the urethra." [MONDO:patterns/location] +synonym: "neoplasm of the urethra" EXACT [NCIT:C3428] +synonym: "neoplasm of urethra" EXACT [MONDO:patterns/neoplasm, NCIT:C3428] +synonym: "neoplasms. urethra" EXACT [NCIT:C3428] +synonym: "tumor of the urethra" EXACT [NCIT:C3428] +synonym: "tumor of urethra" EXACT [MONDO:patterns/neoplasm, NCIT:C3428] +synonym: "tumors. urethra" EXACT [NCIT:C3428] +synonym: "urethra neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "urethra neoplasms" EXACT [NCIT:C3428] +synonym: "urethra tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3428] +synonym: "urethra tumors" EXACT [NCIT:C3428] +synonym: "urethral neoplasm" EXACT [NCIT:C3428] +synonym: "urethral neoplasms" EXACT [NCIT:C3428] +synonym: "urethral tumor" EXACT [NCIT:C3428] +synonym: "urethral tumors" EXACT [NCIT:C3428] +xref: EFO:0003846 {source="MONDO:equivalentTo"} +xref: NCIT:C3428 {source="MONDO:equivalentTo"} +is_a: MONDO:0004184 {source="MONDO:Redundant", source="NCIT:C3428"} ! urethral disorder +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C3428"} ! urinary system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch NCIT:C3428 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021240 +name: tongue neoplasm +def: "A neoplasm (disease) that involves the tongue." [MONDO:patterns/location] +synonym: "neoplasm of the tongue" EXACT [NCIT:C3416] +synonym: "neoplasm of tongue" EXACT [MONDO:patterns/neoplasm, NCIT:C3416] +synonym: "tongue neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "tongue tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3416] +synonym: "tumor of the tongue" EXACT [NCIT:C3416] +synonym: "tumor of tongue" EXACT [MONDO:patterns/neoplasm, NCIT:C3416] +xref: EFO:0003871 {source="MONDO:equivalentTo"} +xref: NCIT:C3416 {source="MONDO:equivalentTo"} +xref: SCTID:126778001 {source="MONDO:equivalentTo"} +is_a: MONDO:0001165 ! tongue disorder +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3416/inferred"} ! head and neck neoplasm +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001723 ! tongue +property_value: exactMatch http://identifiers.org/snomedct/126778001 +property_value: exactMatch NCIT:C3416 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021242 +name: sublingual gland neoplasm +def: "A neoplasm (disease) that involves the sublingual gland." [MONDO:patterns/location] +synonym: "neoplasm of sublingual gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3392] +synonym: "neoplasm of the sublingual gland" EXACT [NCIT:C3392] +synonym: "sublingual gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sublingual gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3392] +synonym: "tumor of sublingual gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3392] +synonym: "tumor of the sublingual gland" EXACT [NCIT:C3392] +xref: EFO:1001430 {source="MONDO:equivalentTo"} +xref: MESH:D013362 {source="MONDO:equivalentTo"} +xref: NCIT:C3392 {source="MONDO:equivalentTo"} +xref: SCTID:126790004 {source="MONDO:equivalentTo"} +xref: UMLS:C0038554 {source="NCIT:C3392", source="MONDO:equivalentTo"} +is_a: MONDO:0021368 {source="MONDO:Redundant", source="NCIT:C3392"} ! neoplasm of major salivary gland +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001832 ! sublingual gland +relationship: disease_has_location UBERON:0001832 ! sublingual gland +property_value: exactMatch http://identifiers.org/mesh/D013362 +property_value: exactMatch http://identifiers.org/snomedct/126790004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038554 +property_value: exactMatch NCIT:C3392 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021243 +name: parotid gland neoplasm +def: "A neoplasm (disease) that involves the parotid gland." [MONDO:patterns/location] +synonym: "neoplasm of parotid" EXACT [NCIT:C3314] +synonym: "neoplasm of parotid gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3314] +synonym: "neoplasm of the parotid" EXACT [NCIT:C3314] +synonym: "neoplasm of the parotid gland" EXACT [NCIT:C3314] +synonym: "parotid gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "parotid gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3314] +synonym: "parotid neoplasm" EXACT [NCIT:C3314] +synonym: "parotid tumor" EXACT [NCIT:C3314] +synonym: "tumor of parotid" EXACT [NCIT:C3314] +synonym: "tumor of parotid gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3314] +synonym: "tumor of the parotid" EXACT [NCIT:C3314] +synonym: "tumor of the parotid gland" EXACT [NCIT:C3314] +xref: EFO:0003873 {source="MONDO:equivalentTo"} +xref: NCIT:C3314 {source="MONDO:equivalentTo"} +xref: SCTID:126788000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005899 ! parotid disorder +is_a: MONDO:0021368 {source="MONDO:Redundant", source="NCIT:C3314"} ! neoplasm of major salivary gland +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch http://identifiers.org/snomedct/126788000 +property_value: exactMatch NCIT:C3314 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021244 +name: submandibular gland neoplasm +def: "A neoplasm (disease) that involves the submandibular gland." [MONDO:patterns/location] +synonym: "neoplasm of submandibular gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3393] +synonym: "neoplasm of the submandibular gland" EXACT [NCIT:C3393] +synonym: "submandibular gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "submandibular gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3393] +synonym: "tumor of submandibular gland" EXACT [MONDO:patterns/neoplasm, NCIT:C3393] +synonym: "tumor of the submandibular gland" EXACT [NCIT:C3393] +xref: EFO:1001853 {source="MONDO:equivalentTo"} +xref: MESH:D013365 {source="MONDO:equivalentTo"} +xref: NCIT:C3393 {source="MONDO:equivalentTo"} +xref: SCTID:254464000 {source="MONDO:equivalentTo"} +xref: UMLS:C0038558 {source="NCIT:C3393", source="MONDO:equivalentTo"} +is_a: MONDO:0001597 ! submandibular gland disorder +is_a: MONDO:0021368 {source="MONDO:Redundant", source="NCIT:C3393"} ! neoplasm of major salivary gland +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001736 ! submandibular gland +property_value: exactMatch http://identifiers.org/mesh/D013365 +property_value: exactMatch http://identifiers.org/snomedct/254464000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0038558 +property_value: exactMatch NCIT:C3393 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021245 +name: oral cavity neoplasm +def: "A neoplasm (disease) that involves the oral cavity." [MONDO:patterns/location] +synonym: "mouth neoplasm" EXACT [NCIT:C7606] +synonym: "mouth tumor" EXACT [NCIT:C7606] +synonym: "neoplasm of oral cavity" EXACT [MONDO:patterns/neoplasm] +synonym: "oral cavity neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "oral cavity tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C7606] +synonym: "tumor of mouth" RELATED [] +synonym: "tumor of oral cavity" EXACT [MONDO:patterns/neoplasm] +xref: EFO:0003868 {source="MONDO:equivalentTo"} +xref: NCIT:C7606 {source="MONDO:equivalentTo"} +xref: SCTID:235075007 {source="MONDO:equivalentTo"} +xref: UMLS:C0026640 {source="MONDO:equivalentTo", source="NCIT:C7606"} +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0006858 {source="MONDO:Redundant", source="NCIT:C7606/inferred"} ! mouth disorder +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000167 ! oral cavity +relationship: disease_has_location UBERON:0000167 ! oral cavity +property_value: exactMatch http://identifiers.org/snomedct/235075007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0026640 +property_value: exactMatch NCIT:C7606 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021246 +name: pharynx neoplasm +def: "A neoplasm (disease) that involves the pharynx." [MONDO:patterns/location] +synonym: "neoplasm of pharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3325] +synonym: "neoplasm of the pharynx" EXACT [NCIT:C3325] +synonym: "pharyngeal neoplasms" EXACT [NCIT:C3325] +synonym: "pharyngeal tumor" EXACT [NCIT:C3325] +synonym: "pharynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pharynx tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3325] +synonym: "tumor of pharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3325] +synonym: "tumor of the pharynx" EXACT [NCIT:C3325] +xref: NCIT:C3325 {source="MONDO:equivalentTo"} +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0006562 ! pharynx +relationship: disease_has_location UBERON:0006562 ! pharynx +property_value: exactMatch NCIT:C3325 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021248 +name: nervous system neoplasm +def: "A neoplasm (disease) that involves the nervous system." [MONDO:patterns/location] +synonym: "neoplasm of nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C3268] +synonym: "neoplasm of the nervous system" EXACT [NCIT:C3268] +synonym: "nervous system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "nervous system neoplasms" EXACT [NCIT:C3268] +synonym: "nervous system tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3268] +synonym: "nervous system tumour" EXACT [NCIT:C3268] +synonym: "tumor of nervous system" EXACT [MONDO:patterns/neoplasm, NCIT:C3268] +synonym: "tumor of the nervous system" EXACT [NCIT:C3268] +xref: NCIT:C3268 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C3268/inferred"} ! neoplasm +is_a: MONDO:0005071 {source="MONDO:Redundant", source="NCIT:C3268"} ! nervous system disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001016 ! nervous system +property_value: exactMatch NCIT:C3268 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021249 +name: lip neoplasm +def: "A neoplasm (disease) that involves the lip." [MONDO:patterns/location] +synonym: "lip neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "lip neoplasms" EXACT [NCIT:C3191] +synonym: "lip tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3191] +synonym: "neoplasm of Lip" EXACT [NCIT:C3191] +synonym: "neoplasm of lip" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the Lip" EXACT [NCIT:C3191] +synonym: "tumor of Lip" EXACT [NCIT:C3191] +synonym: "tumor of lip" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Lip" EXACT [NCIT:C3191] +xref: NCIT:C3191 {source="MONDO:equivalentTo"} +xref: SCTID:126770008 {source="MONDO:equivalentTo"} +is_a: MONDO:0004748 {source="MONDO:Redundant", source="NCIT:C3191"} ! lip disorder +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3191/inferred"} ! head and neck neoplasm +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001833 ! lip +property_value: exactMatch http://identifiers.org/snomedct/126770008 +property_value: exactMatch NCIT:C3191 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021250 +name: tonsil neoplasm +def: "A neoplasm (disease) that involves the tonsil." [MONDO:patterns/location] +synonym: "neoplasm of the tonsil" EXACT [NCIT:C3417] +synonym: "neoplasm of tonsil" EXACT [MONDO:patterns/neoplasm, NCIT:C3417] +synonym: "tonsil neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "tonsil tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3417] +synonym: "tonsillar neoplasm" EXACT [NCIT:C3417] +synonym: "tonsillar neoplasms" EXACT [NCIT:C3417] +synonym: "tonsillar tumor" EXACT [NCIT:C3417] +synonym: "tumor of the tonsil" EXACT [NCIT:C3417] +synonym: "tumor of tonsil" EXACT [MONDO:patterns/neoplasm, NCIT:C3417] +xref: NCIT:C3417 {source="MONDO:equivalentTo"} +xref: SCTID:127227003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0020592 ! disorder of pharynx +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C3417/inferred"} ! pharynx neoplasm +is_a: MONDO:0044986 ! lymphoid system disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002372 ! tonsil +relationship: disease_has_location UBERON:0002372 ! tonsil +property_value: exactMatch http://identifiers.org/snomedct/127227003 +property_value: exactMatch NCIT:C3417 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021251 +name: endometrium neoplasm +def: "A neoplasm (disease) that involves the endometrium." [MONDO:patterns/location] +synonym: "endometrial neoplasm" EXACT [NCIT:C3012] +synonym: "endometrial tumor" EXACT [NCIT:C3012] +synonym: "endometrium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "endometrium tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3012] +synonym: "neoplasm of endometrium" EXACT [MONDO:patterns/neoplasm, NCIT:C3012] +synonym: "neoplasm of the endometrium" EXACT [NCIT:C3012] +synonym: "tumor of endometrium" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the endometrium" EXACT [NCIT:C3012] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D016889 {source="MONDO:equivalentTo"} +xref: NCIT:C3012 {source="MONDO:equivalentTo"} +xref: SCTID:123844007 {source="MONDO:equivalentTo"} +is_a: MONDO:0000931 ! endometrial disorder +is_a: MONDO:0021353 {source="MONDO:Redundant", source="NCIT:C3012/inferred"} ! tumor of uterus +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch http://identifiers.org/mesh/D016889 +property_value: exactMatch http://identifiers.org/snomedct/123844007 +property_value: exactMatch NCIT:C3012 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021253 +name: gallbladder neoplasm +def: "A neoplasm (disease) that involves the gall bladder." [MONDO:patterns/location] +synonym: "gall bladder neoplasm" EXACT [] +synonym: "gall bladder neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "gall bladder tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "gallbladder tumor" EXACT [NCIT:C3048] +synonym: "neoplasm of gall bladder" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of gallbladder" EXACT [NCIT:C3048] +synonym: "neoplasm of the gallbladder" EXACT [NCIT:C3048] +synonym: "tumor of gall bladder" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of gallbladder" EXACT [NCIT:C3048] +synonym: "tumor of the gallbladder" EXACT [NCIT:C3048] +xref: MESH:D005706 {source="MONDO:equivalentTo"} +xref: NCIT:C3048 {source="MONDO:equivalentTo"} +xref: UMLS:C0016978 {source="MONDO:equivalentTo", source="NCIT:C3048"} +is_a: MONDO:0002514 {source="MONDO:Redundant", source="NCIT:C3048"} ! hepatobiliary neoplasm +is_a: MONDO:0005281 {source="MONDO:Redundant", source="NCIT:C3048"} ! gallbladder disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch http://identifiers.org/mesh/D005706 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0016978 +property_value: exactMatch NCIT:C3048 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021257 +name: glomus jugulare neoplasm +def: "A neoplasm (disease) that involves the jugular body." [MONDO:patterns/location] +comment: Reason: duplicate. This OMIM ID seems to represent the whole series. This will be merged with MONDO_0000070 mycobacterium tuberculosis, susceptibility' +subset: obsoletion_candidate +synonym: "jugular body neoplasm" EXACT [] +synonym: "jugular body neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "jugular body tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of jugular body" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of jugular body" EXACT [MONDO:patterns/neoplasm] +is_a: MONDO:0004634 ! vein disorder +is_a: MONDO:0021080 ! blood vessel neoplasm +is_a: MONDO:0021351 ! neoplasm of neck +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0034972 ! jugular body +relationship: disease_has_location UBERON:0034972 ! jugular body +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: IAO:0006012 "2022-10-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5166 + +[Term] +id: MONDO:0021258 +name: choroid neoplasm +def: "A neoplasm (disease) that involves the optic choroid." [MONDO:patterns/location] +synonym: "choroid tumor" EXACT [NCIT:C2949] +synonym: "choroidal neoplasm" EXACT [NCIT:C2949] +synonym: "choroidal tumor" EXACT [NCIT:C2949] +synonym: "neoplasm of choroid" EXACT [NCIT:C2949] +synonym: "neoplasm of optic choroid" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the choroid" EXACT [NCIT:C2949] +synonym: "optic choroid neoplasm" EXACT [] +synonym: "optic choroid neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "optic choroid tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of choroid" EXACT [NCIT:C2949] +synonym: "tumor of optic choroid" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the choroid" EXACT [NCIT:C2949] +xref: NCIT:C2949 {source="MONDO:equivalentTo"} +is_a: MONDO:0001898 {source="MONDO:Redundant", source="NCIT:C2949"} ! optic choroid disorder +is_a: MONDO:0021225 {source="MONDO:Redundant", source="NCIT:C2949"} ! uvea neoplasm +is_a: MONDO:0024296 ! vascular neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001776 ! optic choroid +property_value: exactMatch NCIT:C2949 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021259 +name: prostate neoplasm +def: "A neoplasm (disease) that involves the prostate gland." [MONDO:patterns/location] +synonym: "neoplasm of prostate" EXACT [NCIT:C3343] +synonym: "neoplasm of prostate gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the prostate" EXACT [NCIT:C3343] +synonym: "nodular prostate" RELATED [] +synonym: "prostate gland neoplasm" EXACT [] +synonym: "prostate gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "prostate gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "prostate nodule" RELATED [] +synonym: "prostate tumor" EXACT [NCIT:C3343] +synonym: "tumor of prostate" EXACT [NCIT:C3343] +synonym: "tumor of prostate gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the prostate" EXACT [NCIT:C3343] +xref: DOID:13206 {source="MONDO:equivalentTo"} +xref: ICD9:600.1 {source="DOID:13206"} +xref: NCIT:C3343 {source="MONDO:equivalentTo"} +xref: ONCOTREE:PROSTATE {source="MONDO:equivalentTo"} +is_a: MONDO:0003105 {source="DOID:13206/inferred", source="MONDO:Redundant", source="NCIT:C3343"} ! prostate disorder +is_a: MONDO:0006054 {source="MONDO:Redundant", source="NCIT:C3343/inferred"} ! reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch DOID:13206 +property_value: exactMatch NCIT:C3343 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021260 +name: sensory ganglionopathy +def: "A disease or disorder that involves the sensory ganglion." [MONDO:patterns/location] +synonym: "disease of sensory ganglion" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of sensory ganglion" EXACT [] +synonym: "disorder of sensory ganglion" EXACT [MONDO:patterns/location_top] +synonym: "sensory ganglion disease" EXACT [] +synonym: "sensory ganglion disease or disorder" EXACT [MONDO:patterns/location] +is_a: MONDO:0005071 ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001800 ! sensory ganglion +relationship: disease_has_location UBERON:0001800 ! sensory ganglion +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0021275 +name: papilloma of eyelid +def: "A papilloma that involves the eyelid." [MONDO:patterns/location] +synonym: "eyelid papilloma" EXACT [MONDO:patterns/location, NCIT:C4061] +synonym: "papilloma of the eyelid" EXACT [NCIT:C4061] +xref: NCIT:C4061 {source="MONDO:equivalentTo"} +xref: SCTID:314515006 {source="MONDO:equivalentTo"} +xref: UMLS:C1142491 {source="MONDO:equivalentTo", source="NCIT:C4061"} +is_a: MONDO:0002536 ! skin papilloma +is_a: MONDO:0021605 {source="MONDO:Redundant", source="NCIT:C4061"} ! benign eyelid neoplasm +intersection_of: MONDO:0002363 ! papilloma +intersection_of: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch http://identifiers.org/snomedct/314515006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1142491 +property_value: exactMatch NCIT:C4061 + +[Term] +id: MONDO:0021309 +name: malignant neoplasm of endocervix +def: "A cancer that involves the endocervix." [MONDO:patterns/location] +synonym: "cancer of endocervix" EXACT [MONDO:patterns/cancer] +synonym: "endocervix cancer" EXACT [MONDO:patterns/location] +synonym: "malignant endocervical neoplasm" EXACT [NCIT:C3553] +synonym: "malignant endocervical tumor" EXACT [NCIT:C3553] +synonym: "malignant endocervix neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C3553] +synonym: "malignant endocervix tumor" EXACT [NCIT:C3553] +synonym: "malignant neoplasm of endocervix" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the endocervix" EXACT [NCIT:C3553] +synonym: "malignant neoplasm of the uterine endocervix" EXACT [NCIT:C3553] +synonym: "malignant neoplasm of uterine endocervix" EXACT [NCIT:C3553] +synonym: "malignant tumor of endocervix" EXACT [NCIT:C3553] +synonym: "malignant tumor of the endocervix" EXACT [NCIT:C3553] +synonym: "malignant tumor of the uterine endocervix" EXACT [NCIT:C3553] +synonym: "malignant tumor of uterine endocervix" EXACT [NCIT:C3553] +synonym: "malignant uterine endocervix neoplasm" EXACT [NCIT:C3553] +synonym: "malignant uterine endocervix tumor" EXACT [NCIT:C3553] +xref: ICD10CM:C53.0 {source="MONDO:equivalentTo"} +xref: ICD9:180.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3553 {source="MONDO:equivalentTo"} +xref: SCTID:372097009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002974 {source="MONDO:Redundant", source="NCIT:C3553"} ! cervical cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000458 ! endocervix +relationship: disease_has_location UBERON:0000458 ! endocervix +property_value: exactMatch http://identifiers.org/snomedct/372097009 +property_value: exactMatch https://icd.codes/icd10cm/C53.0 +property_value: exactMatch NCIT:C3553 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021310 +name: malignant tumor of neck +def: "A cancer that involves the neck." [MONDO:patterns/location] +synonym: "cancer of neck" EXACT [MONDO:patterns/cancer, NCIT:C4940] +synonym: "cancer of the neck" EXACT [NCIT:C4940] +synonym: "malignant neck neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4940] +synonym: "malignant neck tumor" EXACT [NCIT:C4940] +synonym: "malignant neoplasm of neck" EXACT [MONDO:patterns/cancer, NCIT:C4940] +synonym: "malignant neoplasm of the neck" EXACT [NCIT:C4940] +synonym: "malignant tumor of the neck" EXACT [NCIT:C4940] +synonym: "neck cancer" EXACT [MONDO:patterns/location, NCIT:C4940] +xref: NCIT:C4940 {source="MONDO:equivalentTo"} +xref: SCTID:363489000 {source="MONDO:equivalentTo"} +xref: UMLS:C0746787 {source="MONDO:equivalentTo", source="NCIT:C4940"} +is_a: MONDO:0005627 {source="MONDO:Redundant", source="NCIT:C4940"} ! head and neck cancer +is_a: MONDO:0021351 {source="MONDO:Redundant", source="NCIT:C4940"} ! neoplasm of neck +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0000974 ! neck +property_value: exactMatch http://identifiers.org/snomedct/363489000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0746787 +property_value: exactMatch NCIT:C4940 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021311 +name: malignant tumor of parathyroid gland +def: "A cancer that involves the parathyroid gland." [MONDO:patterns/location] +synonym: "cancer of parathyroid gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of parathyroid" EXACT [NCIT:C9322] +synonym: "malignant neoplasm of parathyroid gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the parathyroid" EXACT [NCIT:C9322] +synonym: "malignant neoplasm of the parathyroid gland" EXACT [NCIT:C9322] +synonym: "malignant parathyroid gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9322] +synonym: "malignant parathyroid gland tumor" EXACT [NCIT:C9322] +synonym: "malignant parathyroid neoplasm" EXACT [NCIT:C9322] +synonym: "malignant parathyroid tumor" EXACT [NCIT:C9322] +synonym: "malignant tumor of parathyroid" EXACT [NCIT:C9322] +synonym: "malignant tumor of the parathyroid" EXACT [NCIT:C9322] +synonym: "malignant tumor of the parathyroid gland" EXACT [NCIT:C9322] +synonym: "parathyroid cancer" EXACT [MONDO:patterns/location] +synonym: "parathyroid gland cancer" EXACT [MONDO:patterns/location] +xref: ICD9:194.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9322 {source="MONDO:equivalentTo"} +xref: ONCOTREE:PTH {source="MONDO:equivalentTo"} +xref: SCTID:363481002 {source="MONDO:equivalentTo"} +is_a: MONDO:0021069 ! malignant endocrine neoplasm +is_a: MONDO:0021360 {source="MONDO:Redundant", source="NCIT:C9322"} ! tumor of parathyroid gland +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +property_value: exactMatch http://identifiers.org/snomedct/363481002 +property_value: exactMatch NCIT:C9322 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021312 +name: malignant tumor of adrenal cortex +def: "A cancer that involves the adrenal cortex." [MONDO:patterns/location] +synonym: "adrenal cortex cancer" EXACT [MONDO:patterns/location] +synonym: "cancer of adrenal cortex" EXACT [MONDO:patterns/cancer] +synonym: "malignant adrenal cortex neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C9327] +synonym: "malignant adrenal cortex tumor" EXACT [NCIT:C9327] +synonym: "malignant adrenocortical neoplasm" EXACT [NCIT:C9327] +synonym: "malignant adrenocortical tumor" EXACT [NCIT:C9327] +synonym: "malignant neoplasm of adrenal cortex" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the adrenal cortex" EXACT [NCIT:C9327] +synonym: "malignant tumor of the adrenal cortex" EXACT [NCIT:C9327] +xref: NCIT:C9327 {source="MONDO:equivalentTo"} +xref: SCTID:371964008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002817 {source="MONDO:Redundant", source="NCIT:C9327"} ! adrenal gland cancer +is_a: MONDO:0036591 ! adrenal cortex neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001235 ! adrenal cortex +property_value: exactMatch http://identifiers.org/snomedct/371964008 +property_value: exactMatch NCIT:C9327 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021313 +name: eyelid cancer +def: "A cancer that involves the eyelid." [MONDO:patterns/location] +synonym: "cancer of eyelid" EXACT [MONDO:patterns/cancer] +synonym: "eyelid cancer" EXACT [MONDO:patterns/location] +synonym: "malignant eyelid neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C6786] +synonym: "malignant eyelid tumor" EXACT [NCIT:C6786] +synonym: "malignant neoplasm of eyelid" EXACT [MONDO:patterns/cancer, NCIT:C6786] +synonym: "malignant neoplasm of the eyelid" EXACT [NCIT:C6786] +synonym: "malignant tumor of eyelid" EXACT [NCIT:C6786] +synonym: "malignant tumor of the eyelid" EXACT [NCIT:C6786] +xref: ICD9:173.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6786 {source="MONDO:equivalentTo"} +xref: SCTID:231829006 {source="MONDO:equivalentTo"} +is_a: MONDO:0002235 {source="MONDO:Redundant", source="NCIT:C6786"} ! eyelid neoplasm +is_a: MONDO:0002236 {source="MONDO:Redundant", source="NCIT:C6786"} ! ocular cancer +is_a: MONDO:0002898 ! skin cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch http://identifiers.org/snomedct/231829006 +property_value: exactMatch NCIT:C6786 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021315 +name: malignant tumor of nasopharynx +def: "A cancer that involves the nasopharynx." [MONDO:patterns/location] +synonym: "cancer of nasopharynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant nasopharyngeal neoplasm" EXACT [NCIT:C9321] +synonym: "malignant nasopharyngeal tumor" EXACT [NCIT:C9321] +synonym: "malignant nasopharynx neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of nasopharynx" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the nasopharynx" EXACT [NCIT:C9321] +synonym: "malignant tumor of the nasopharynx" EXACT [NCIT:C9321] +synonym: "nasopharynx cancer" EXACT [MONDO:patterns/location] +xref: ICD9:147.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:147.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9321 {source="MONDO:equivalentTo"} +xref: SCTID:187692001 {source="MONDO:equivalentTo"} +xref: UMLS:C0153392 {source="NCIT:C9321", source="MONDO:equivalentTo"} +xref: UMLS:C0238301 {source="MONDO:equivalentTo"} +is_a: MONDO:0005375 {source="MONDO:Redundant", source="NCIT:C9321"} ! nasopharyngeal neoplasm +is_a: MONDO:0005517 ! pharynx cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001728 ! nasopharynx +property_value: exactMatch http://identifiers.org/snomedct/187692001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153392 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238301 +property_value: exactMatch NCIT:C9321 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021316 +name: malignant tumor of minor salivary gland +def: "A cancer that involves the minor salivary gland." [MONDO:patterns/location] +synonym: "cancer of minor salivary gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant minor salivary gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4410] +synonym: "malignant minor salivary gland tumor" EXACT [NCIT:C4410] +synonym: "malignant neoplasm of minor salivary gland" EXACT [MONDO:patterns/cancer, NCIT:C4410] +synonym: "malignant neoplasm of the minor salivary gland" EXACT [NCIT:C4410] +synonym: "malignant tumor of the minor salivary gland" EXACT [NCIT:C4410] +synonym: "minor salivary gland cancer" RELATED [MONDO:patterns/location] +xref: NCIT:C4410 {source="MONDO:equivalentTo"} +xref: SCTID:363485006 {source="MONDO:equivalentTo"} +xref: UMLS:C0345614 {source="MONDO:equivalentTo", source="NCIT:C4410"} +is_a: MONDO:0004669 ! salivary gland cancer +is_a: MONDO:0004727 ! vestibule of mouth cancer +is_a: MONDO:0021370 {source="MONDO:Redundant", source="NCIT:C4410"} ! neoplasm of minor salivary gland +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001830 ! minor salivary gland +property_value: exactMatch http://identifiers.org/snomedct/363485006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345614 +property_value: exactMatch NCIT:C4410 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021317 +name: cancer of cerebellum +def: "A cancer that involves the cerebellum." [MONDO:patterns/location] +synonym: "cancer of cerebellum" EXACT [MONDO:patterns/cancer] +synonym: "cancer of the cerebellum" EXACT [NCIT:C3569] +synonym: "cerebellar cancer" EXACT [NCIT:C3569] +synonym: "cerebellar neoplasm, malignant" EXACT [NCIT:C3569] +synonym: "cerebellar tumor, malignant" EXACT [NCIT:C3569] +synonym: "cerebellum cancer" EXACT [MONDO:patterns/location] +synonym: "malignant cerebellar neoplasm" EXACT [NCIT:C3569] +synonym: "malignant cerebellar neoplasms" EXACT [NCIT:C3569] +synonym: "malignant cerebellar tumor" EXACT [NCIT:C3569] +synonym: "malignant cerebellum neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of cerebellum" EXACT [MONDO:patterns/cancer, NCIT:C3569] +synonym: "malignant neoplasm of the cerebellum" EXACT [NCIT:C3569] +synonym: "malignant tumor of cerebellum" EXACT [NCIT:C3569] +synonym: "malignant tumor of the cerebellum" EXACT [NCIT:C3569] +xref: ICD9:191.6 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3569 {source="MONDO:equivalentTo"} +xref: SCTID:449420002 {source="MONDO:equivalentTo"} +is_a: MONDO:0001657 {source="MONDO:Redundant", source="NCIT:C3569/inferred"} ! brain cancer +is_a: MONDO:0002913 {source="MONDO:Redundant", source="NCIT:C3569"} ! cerebellar neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch http://identifiers.org/snomedct/449420002 +property_value: exactMatch NCIT:C3569 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021320 +name: malignant tumor of floor of mouth +def: "A cancer that involves the mouth floor." [MONDO:patterns/location] +synonym: "cancer of mouth floor" EXACT [MONDO:patterns/cancer] +synonym: "malignant floor of mouth neoplasm" EXACT [NCIT:C9318] +synonym: "malignant floor of mouth tumor" EXACT [NCIT:C9318] +synonym: "malignant floor of the mouth neoplasm" EXACT [NCIT:C9318] +synonym: "malignant floor of the mouth tumor" EXACT [NCIT:C9318] +synonym: "malignant mouth floor neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of floor of mouth" EXACT [NCIT:C9318] +synonym: "malignant neoplasm of mouth floor" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the floor of the mouth" EXACT [NCIT:C9318] +synonym: "malignant tumor of the floor of the mouth" EXACT [NCIT:C9318] +synonym: "mouth floor cancer" EXACT [MONDO:patterns/location] +xref: ICD9:144.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:144.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C9318 {source="MONDO:equivalentTo"} +xref: SCTID:363385007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002516 ! digestive system cancer +is_a: MONDO:0005627 {source="MONDO:Redundant", source="NCIT:C9318/inferred"} ! head and neck cancer +is_a: MONDO:0021383 {source="MONDO:Redundant", source="NCIT:C9318"} ! neoplasm of floor of mouth +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003679 ! mouth floor +property_value: exactMatch http://identifiers.org/snomedct/363385007 +property_value: exactMatch NCIT:C9318 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021321 +name: malignant tumor of extrahepatic bile duct +def: "A cancer that involves the extrahepatic bile duct." [MONDO:patterns/location] +synonym: "cancer of extrahepatic bile duct" EXACT [MONDO:patterns/cancer] +synonym: "extrahepatic bile duct cancer" BROAD [MONDO:patterns/location] +synonym: "malignant extrahepatic bile duct neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7483] +synonym: "malignant extrahepatic bile duct tumor" EXACT [NCIT:C7483] +synonym: "malignant neoplasm of extrahepatic bile duct" EXACT [MONDO:patterns/cancer, NCIT:C7483] +synonym: "malignant neoplasm of the extrahepatic bile duct" EXACT [NCIT:C7483] +synonym: "malignant tumor of the extrahepatic bile duct" EXACT [NCIT:C7483] +xref: ICD9:156.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: ICD9:156.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C7483 {source="MONDO:equivalentTo"} +xref: SCTID:363416002 {source="MONDO:equivalentTo"} +xref: UMLS:C0153453 {source="NCIT:C7483", source="MONDO:equivalentTo"} +is_a: MONDO:0003059 ! bile duct cancer +is_a: MONDO:0021385 {source="MONDO:Redundant", source="NCIT:C7483"} ! extrahepatic bile duct neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003703 ! extrahepatic bile duct +property_value: exactMatch http://identifiers.org/snomedct/363416002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153453 +property_value: exactMatch NCIT:C7483 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021322 +name: malignant tumor of meninges +def: "A cancer that involves the meningeal cluster." [MONDO:patterns/location] +synonym: "cancer of meningeal cluster" EXACT [MONDO:patterns/cancer] +synonym: "cancer of meninges" EXACT [NCIT:C4628] +synonym: "cancer of the meninges" EXACT [NCIT:C4628] +synonym: "malignant meningeal cluster neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant meningeal neoplasms" EXACT [NCIT:C4628] +synonym: "malignant meningeal tumor" EXACT [NCIT:C4628] +synonym: "malignant meninges neoplasm" EXACT [NCIT:C4628] +synonym: "malignant meninges tumor" EXACT [NCIT:C4628] +synonym: "malignant neoplasm of meningeal cluster" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of meninges" EXACT [NCIT:C4628] +synonym: "malignant neoplasm of the meninges" EXACT [NCIT:C4628] +synonym: "malignant neoplasms of meninges" EXACT [NCIT:C4628] +synonym: "malignant tumor of the meninges" EXACT [NCIT:C4628] +synonym: "meningeal cancer" EXACT [NCIT:C4628] +synonym: "meningeal cluster cancer" EXACT [MONDO:patterns/location] +synonym: "meningeal tumors, malignant" EXACT [NCIT:C4628] +xref: NCIT:C4628 {source="MONDO:equivalentTo"} +xref: SCTID:363497007 {source="MONDO:equivalentTo"} +xref: UMLS:C0348375 {source="NCIT:C4628", source="MONDO:equivalentTo"} +is_a: MONDO:0002714 {source="MONDO:Redundant", source="NCIT:C4628"} ! central nervous system cancer +is_a: MONDO:0016743 {source="MONDO:Redundant", source="NCIT:C4628"} ! tumor of meninges +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0010743 ! meningeal cluster +property_value: exactMatch http://identifiers.org/snomedct/363497007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0348375 +property_value: exactMatch NCIT:C4628 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021323 +name: malignant neoplasm of chest wall +def: "A cancer that involves the chest wall." [MONDO:patterns/location] +synonym: "cancer of chest wall" EXACT [MONDO:patterns/cancer] +synonym: "chest wall cancer" EXACT [MONDO:patterns/location] +synonym: "malignant chest wall neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4580] +synonym: "malignant chest wall tumor" EXACT [NCIT:C4580] +synonym: "malignant neoplasm of chest wall" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of the chest wall" EXACT [NCIT:C4580] +synonym: "malignant tumor of chest wall" EXACT [NCIT:C4580] +synonym: "malignant tumor of the chest wall" EXACT [NCIT:C4580] +xref: NCIT:C4580 {source="MONDO:equivalentTo"} +xref: SCTID:712750007 {source="MONDO:equivalentTo"} +xref: UMLS:C0346948 {source="NCIT:C4580", source="MONDO:equivalentTo"} +is_a: MONDO:0003274 {source="MONDO:Redundant", source="NCIT:C4580"} ! thoracic cancer +is_a: MONDO:0021388 {source="MONDO:Redundant", source="NCIT:C4580"} ! neoplasm of chest wall +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0016435 ! chest wall +property_value: exactMatch http://identifiers.org/snomedct/712750007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346948 +property_value: exactMatch NCIT:C4580 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0021327 +name: carcinoma of urethra +def: "A carcinoma that involves the urethra." [MONDO:patterns/location] +synonym: "carcinoma of the urethra" EXACT [NCIT:C9106] +synonym: "carcinoma of urethra" EXACT [MONDO:patterns/carcinoma] +synonym: "urethra carcinoma" EXACT [MONDO:patterns/location, NCIT:C9106] +synonym: "urethral cancer" EXACT [NCIT:C9106] +synonym: "urethral carcinoma" EXACT [NCIT:C9106] +xref: NCIT:C9106 {source="MONDO:equivalentTo"} +xref: SCTID:448954003 {source="MONDO:equivalentTo"} +is_a: MONDO:0004192 {source="MONDO:Redundant", source="NCIT:C9106"} ! urethra cancer +is_a: MONDO:0004993 {source="MONDO:Redundant", source="NCIT:C9106"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000057 ! urethra +property_value: exactMatch http://identifiers.org/snomedct/448954003 +property_value: exactMatch NCIT:C9106 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021329 +name: carcinoma of soft palate +def: "A carcinoma that arises from the soft palate. The majority are squamous cell carcinomas." [NCIT:C8395] +synonym: "carcinoma of soft palate" EXACT [MONDO:patterns/carcinoma, NCIT:C8395] +synonym: "carcinoma of the soft palate" EXACT [NCIT:C8395] +synonym: "soft palate cancer" BROAD [NCIT:C8395] +synonym: "soft palate carcinoma" EXACT [MONDO:patterns/location, NCIT:C8395] +xref: NCIT:C8395 {source="MONDO:equivalentTo"} +xref: SCTID:254435009 {source="MONDO:equivalentTo"} +xref: UMLS:C0345555 {source="MONDO:equivalentTo", source="NCIT:C8395"} +is_a: MONDO:0004611 {source="MONDO:Redundant", source="NCIT:C8395"} ! soft palate cancer +is_a: MONDO:0044925 ! oral cavity carcinoma +is_a: MONDO:0044926 ! oropharyngeal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001733 ! soft palate +property_value: exactMatch http://identifiers.org/snomedct/254435009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345555 +property_value: exactMatch NCIT:C8395 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021331 +name: carcinoma of parotid gland +def: "A carcinoma that involves the parotid gland." [MONDO:patterns/location] +synonym: "carcinoma of parotid" EXACT [NCIT:C6791] +synonym: "carcinoma of parotid gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the parotid" EXACT [NCIT:C6791] +synonym: "carcinoma of the parotid gland" EXACT [NCIT:C6791] +synonym: "parotid carcinoma" EXACT [NCIT:C6791] +synonym: "parotid gland cancer" BROAD [NCIT:C6791] +synonym: "parotid gland carcinoma" EXACT [MONDO:patterns/location, NCIT:C6791] +xref: EFO:1000460 {source="MONDO:equivalentTo"} +xref: NCIT:C6791 {source="MONDO:equivalentTo"} +xref: SCTID:254462001 {source="MONDO:equivalentTo"} +xref: UMLS:C0345602 {source="NCIT:C6791", source="MONDO:equivalentTo"} +is_a: MONDO:0004700 {source="MONDO:Redundant", source="NCIT:C6791"} ! parotid gland cancer +is_a: MONDO:0006284 {source="MONDO:Redundant", source="NCIT:C6791"} ! major salivary gland carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch http://identifiers.org/snomedct/254462001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345602 +property_value: exactMatch NCIT:C6791 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021333 +name: carcinoma of lip +def: "A carcinoma that involves the lip." [MONDO:patterns/location] +synonym: "carcinoma of lip" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the Lip" EXACT [NCIT:C3490] +synonym: "lip cancer" BROAD [NCIT:C3490] +synonym: "lip carcinoma" EXACT [MONDO:patterns/location, NCIT:C3490] +xref: NCIT:C3490 {source="MONDO:equivalentTo"} +xref: SCTID:269515006 {source="MONDO:equivalentTo"} +xref: UMLS:C0149637 {source="NCIT:C3490", source="MONDO:equivalentTo"} +is_a: MONDO:0006834 {source="MONDO:Redundant", source="NCIT:C3490"} ! lip cancer +is_a: MONDO:0044925 ! oral cavity carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001833 ! lip +property_value: exactMatch http://identifiers.org/snomedct/269515006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149637 +property_value: exactMatch NCIT:C3490 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021335 +name: carcinoma of duodenum +def: "A carcinoma that involves the duodenum." [MONDO:patterns/location] +synonym: "cancer of duodenum" BROAD [NCIT:C4803] +synonym: "cancer of the duodenum" BROAD [NCIT:C4803] +synonym: "carcinoma of duodenum" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the duodenum" EXACT [NCIT:C4803] +synonym: "duodenal cancer" BROAD [NCIT:C4803] +synonym: "duodenal carcinoma" EXACT [NCIT:C4803] +synonym: "duodenum carcinoma" EXACT [MONDO:patterns/location] +xref: NCIT:C4803 {source="MONDO:equivalentTo"} +xref: SCTID:254570009 {source="MONDO:equivalentTo"} +is_a: MONDO:0000920 {source="MONDO:Redundant", source="NCIT:C4803"} ! duodenum cancer +is_a: MONDO:0005522 {source="MONDO:Redundant", source="NCIT:C4803"} ! small intestine carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: exactMatch http://identifiers.org/snomedct/254570009 +property_value: exactMatch NCIT:C4803 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021337 +name: tonsil carcinoma +def: "A carcinoma that involves the tonsil." [MONDO:patterns/location] +synonym: "cancer of the tonsil" BROAD [NCIT:C4825] +synonym: "cancer of tonsil" BROAD [NCIT:C4825] +synonym: "carcinoma of the tonsil" EXACT [NCIT:C4825] +synonym: "carcinoma of tonsil" EXACT [MONDO:patterns/carcinoma, NCIT:C4825] +synonym: "tonsil cancer" BROAD [NCIT:C4825] +synonym: "tonsil carcinoma" EXACT [MONDO:patterns/location] +synonym: "tonsillar cancer" BROAD [NCIT:C4825] +synonym: "tonsillar carcinoma" EXACT [NCIT:C4825] +xref: NCIT:C4825 {source="MONDO:equivalentTo"} +xref: SCTID:274085008 {source="MONDO:equivalentTo"} +xref: UMLS:C0558355 {source="MONDO:equivalentTo", source="NCIT:C4825"} +is_a: MONDO:0006998 {source="MONDO:Redundant", source="NCIT:C4825"} ! tonsil cancer +is_a: MONDO:0044926 ! oropharyngeal carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002372 ! tonsil +property_value: exactMatch http://identifiers.org/snomedct/274085008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0558355 +property_value: exactMatch NCIT:C4825 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021339 +name: carcinoma of hard palate +def: "A carcinoma that involves the hard palate." [MONDO:patterns/location] +synonym: "carcinoma of hard palate" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the hard palate" EXACT [NCIT:C8394] +synonym: "hard palate carcinoma" EXACT [MONDO:patterns/location, NCIT:C8394] +xref: NCIT:C8394 {source="MONDO:equivalentTo"} +xref: SCTID:254434008 {source="MONDO:equivalentTo"} +xref: UMLS:C0345550 {source="MONDO:equivalentTo", source="NCIT:C8394"} +is_a: MONDO:0004719 {source="MONDO:Redundant", source="NCIT:C8394"} ! hard palate cancer +is_a: MONDO:0044925 ! oral cavity carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003216 ! hard palate +property_value: exactMatch http://identifiers.org/snomedct/254434008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345550 +property_value: exactMatch NCIT:C8394 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021343 +name: carcinoma of floor of mouth +def: "A carcinoma that involves the mouth floor." [MONDO:patterns/location] +synonym: "carcinoma of mouth floor" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the floor of the mouth" EXACT [NCIT:C9319] +synonym: "floor of mouth carcinoma" EXACT [NCIT:C9319] +synonym: "floor of the mouth carcinoma" EXACT [NCIT:C9319] +synonym: "mouth floor cancer" BROAD [NCIT:C9319] +synonym: "mouth floor carcinoma" EXACT [MONDO:patterns/location] +xref: NCIT:C9319 {source="MONDO:equivalentTo"} +xref: SCTID:449156009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002038 {source="MONDO:Redundant", source="NCIT:C9319/inferred"} ! head and neck carcinoma +is_a: MONDO:0006181 ! digestive system carcinoma +is_a: MONDO:0021320 {source="MONDO:Redundant", source="NCIT:C9319"} ! malignant tumor of floor of mouth +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003679 ! mouth floor +property_value: exactMatch http://identifiers.org/snomedct/449156009 +property_value: exactMatch NCIT:C9319 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021345 +name: carcinoma of pharynx +def: "A carcinoma that involves the pharynx." [MONDO:patterns/location] +synonym: "cancer of the pharynx" EXACT [NCIT:C9466] +synonym: "carcinoma of pharynx" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of the pharynx" EXACT [NCIT:C9466] +synonym: "pharyngeal carcinoma" EXACT [NCIT:C9466] +synonym: "pharyngeal throat cancer" EXACT [NCIT:C9466] +synonym: "pharynx carcinoma" EXACT [MONDO:patterns/location, NCIT:C9466] +xref: NCIT:C9466 {source="MONDO:equivalentTo"} +xref: SCTID:449254004 {source="MONDO:equivalentTo"} +is_a: MONDO:0006181 ! digestive system carcinoma +is_a: MONDO:0021246 ! pharynx neoplasm +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0006562 ! pharynx +property_value: exactMatch http://identifiers.org/snomedct/449254004 +property_value: exactMatch NCIT:C9466 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021348 +name: neoplasm of testis +def: "A neoplasm (disease) that involves the testis." [MONDO:patterns/location] +synonym: "neoplasm of testis" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the testis" EXACT [NCIT:C3404] +synonym: "testicular neoplasm" EXACT [NCIT:C3404] +synonym: "testicular tumor" EXACT [NCIT:C3404] +synonym: "testis neoplasm" EXACT [ONCOTREE:TESTIS] +synonym: "testis neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "testis tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of testis" EXACT [MONDO:patterns/neoplasm, NCIT:C3404] +synonym: "tumor of the testis" EXACT [NCIT:C3404] +xref: EFO:0004281 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3404 {source="MONDO:equivalentTo"} +xref: ONCOTREE:TESTIS {source="MONDO:equivalentTo"} +xref: SCTID:126900000 {source="MONDO:equivalentTo"} +is_a: MONDO:0002329 {source="MONDO:Redundant", source="NCIT:C3404"} ! testicular disorder +is_a: MONDO:0024582 ! male reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch http://identifiers.org/snomedct/126900000 +property_value: exactMatch NCIT:C3404 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021350 +name: neoplasm of thorax +def: "A neoplasm (disease) that involves the thoracic segment of trunk." [MONDO:patterns/location] +synonym: "neoplasm of the thorax" EXACT [NCIT:C3406] +synonym: "neoplasm of thoracic segment of trunk" EXACT [MONDO:patterns/neoplasm] +synonym: "thoracic neoplasm" EXACT [NCIT:C3406] +synonym: "thoracic segment of trunk neoplasm" EXACT [] +synonym: "thoracic segment of trunk neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "thoracic segment of trunk tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "thoracic tumor" EXACT [NCIT:C3406] +synonym: "tumor of the thorax" EXACT [NCIT:C3406] +synonym: "tumor of thoracic segment of trunk" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of thorax" EXACT [NCIT:C3406] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3406 {source="MONDO:equivalentTo"} +xref: SCTID:255058005 {source="MONDO:equivalentTo"} +xref: UMLS:C0039981 {source="MONDO:equivalentTo", source="NCIT:C3406"} +is_a: MONDO:0005070 {source="MONDO:Redundant", source="NCIT:C3406/inferred"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000915 ! thoracic segment of trunk +relationship: disease_has_location UBERON:0000915 ! thoracic segment of trunk +property_value: exactMatch http://identifiers.org/snomedct/255058005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0039981 +property_value: exactMatch NCIT:C3406 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021351 +name: neoplasm of neck +def: "A neoplasm (disease) that involves the neck." [MONDO:patterns/location] +synonym: "neck neoplasm" EXACT [NCIT:C3260] +synonym: "neck neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "neck neoplasms (Including All pharyngeal related neoplasms)" EXACT [NCIT:C3260] +synonym: "neck tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3260] +synonym: "neoplasm of neck" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the neck" EXACT [NCIT:C3260] +synonym: "tumor of neck" EXACT [MONDO:patterns/neoplasm, NCIT:C3260] +synonym: "tumor of the neck" EXACT [NCIT:C3260] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3260 {source="MONDO:equivalentTo"} +xref: SCTID:126635000 {source="MONDO:equivalentTo"} +xref: UMLS:C0027533 {source="NCIT:C3260", source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3260"} ! head and neck neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000974 ! neck +relationship: disease_has_location UBERON:0000974 ! neck +property_value: exactMatch http://identifiers.org/snomedct/126635000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027533 +property_value: exactMatch NCIT:C3260 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021353 +name: tumor of uterus +def: "A neoplasm (disease) that involves the uterus." [MONDO:patterns/location] +synonym: "neoplasm of the uterus" EXACT [NCIT:C3435] +synonym: "neoplasm of uterus" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the uterus" EXACT [NCIT:C3435] +synonym: "tumor of uterus" EXACT [MONDO:patterns/neoplasm] +synonym: "uterine neoplasm" EXACT [NCIT:C3435] +synonym: "uterine neoplasms" EXACT [NCIT:C3435] +synonym: "uterine tumor" EXACT [NCIT:C3435] +synonym: "uterus neoplasm" EXACT [ONCOTREE:UTERUS] +synonym: "uterus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "uterus tumor" EXACT [MONDO:patterns/neoplasm] +xref: EFO:0003859 {source="MONDO:equivalentTo"} +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3435 {source="MONDO:equivalentTo"} +xref: ONCOTREE:UTERUS {source="MONDO:equivalentTo"} +xref: SCTID:126908007 {source="MONDO:equivalentTo"} +is_a: MONDO:0002654 {source="MONDO:Redundant", source="NCIT:C3435"} ! uterine disorder +is_a: MONDO:0021148 {source="MONDO:Redundant", source="NCIT:C3435"} ! female reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000995 ! uterus +property_value: exactMatch http://identifiers.org/snomedct/126908007 +property_value: exactMatch NCIT:C3435 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021354 +name: tumor of adipose tissue +def: "A neoplasm (disease) that involves the adipose tissue." [MONDO:patterns/location] +synonym: "adipose tissue neoplasm" EXACT [NCIT:C4248] +synonym: "adipose tissue neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "adipose tissue tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4248] +synonym: "lipomatous neoplasm" EXACT [NCIT:C4248] +synonym: "lipomatous tumor" EXACT [NCIT:C4248] +synonym: "neoplasm of adipose tissue" EXACT [MONDO:patterns/neoplasm, NCIT:C4248] +synonym: "neoplasm of the adipose tissue" EXACT [NCIT:C4248] +synonym: "tumor of adipose tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the adipose tissue" EXACT [NCIT:C4248] +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4248 {source="MONDO:equivalentTo"} +xref: SCTID:254831005 {source="MONDO:equivalentTo"} +xref: UMLS:C0206631 {source="MONDO:equivalentTo", source="NCIT:C4248"} +is_a: MONDO:0002616 {source="NCIT:C4248"} ! mesenchymal cell neoplasm +is_a: MONDO:0021581 ! connective tissue neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001013 ! adipose tissue +relationship: disease_has_location UBERON:0001013 ! adipose tissue +property_value: exactMatch http://identifiers.org/snomedct/254831005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206631 +property_value: exactMatch NCIT:C4248 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021355 +name: neoplasm of esophagus +def: "A neoplasm (disease) that involves the esophagus." [MONDO:patterns/location] +synonym: "esophageal neoplasm" EXACT [NCIT:C3028] +synonym: "esophageal neoplasms, benign and malignant" EXACT [NCIT:C3028] +synonym: "esophageal tumor" EXACT [NCIT:C3028] +synonym: "esophageal tumors" EXACT [NCIT:C3028] +synonym: "esophagus neoplasm" EXACT [NCIT:C3028] +synonym: "esophagus neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "esophagus tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3028] +synonym: "neoplasm of esophagus" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the esophagus" EXACT [NCIT:C3028] +synonym: "tumor of esophagus" EXACT [MONDO:patterns/neoplasm, NCIT:C3028] +synonym: "tumor of the esophagus" EXACT [NCIT:C3028] +xref: NCIT:C3028 {source="MONDO:equivalentTo"} +xref: SCTID:126817006 {source="MONDO:equivalentTo"} +xref: UMLS:C0014859 {source="MONDO:equivalentTo", source="NCIT:C3028"} +is_a: MONDO:0003749 ! esophageal disorder +is_a: MONDO:0021223 {source="MONDO:Redundant", source="NCIT:C3028"} ! digestive system neoplasm +is_a: MONDO:0021350 ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch http://identifiers.org/snomedct/126817006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014859 +property_value: exactMatch NCIT:C3028 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021357 +name: tumor of salivary gland +def: "A neoplasm (disease) that involves the saliva-secreting gland." [MONDO:patterns/location] +synonym: "neoplasm of saliva-secreting gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of salivary gland" EXACT [NCIT:C3361] +synonym: "neoplasm of the salivary gland" EXACT [NCIT:C3361] +synonym: "saliva-secreting gland neoplasm" EXACT [] +synonym: "saliva-secreting gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "saliva-secreting gland tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "salivary gland neoplasm" EXACT [NCIT:C3361] +synonym: "salivary gland tumor" EXACT [NCIT:C3361] +synonym: "tumor of saliva-secreting gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the salivary gland" EXACT [NCIT:C3361] +xref: EFO:0003826 {source="MONDO:equivalentTo"} +xref: NCIT:C3361 {source="MONDO:equivalentTo"} +xref: SCTID:235132004 {source="MONDO:equivalentTo"} +is_a: MONDO:0001142 {source="EFO:0003826", source="MONDO:Redundant", source="NCIT:C3361"} ! salivary gland disorder +is_a: MONDO:0005586 {source="EFO:0003826/inferred", source="MONDO:Redundant", source="NCIT:C3361"} ! head and neck neoplasm +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch http://identifiers.org/snomedct/235132004 +property_value: exactMatch NCIT:C3361 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021358 +name: neoplasm of hypopharynx +def: "A neoplasm (disease) that involves the hypopharynx." [MONDO:patterns/location] +synonym: "hypopharyngeal neoplasm" EXACT [NCIT:C3127] +synonym: "hypopharyngeal neoplasms" EXACT [NCIT:C3127] +synonym: "hypopharyngeal tumor" EXACT [NCIT:C3127] +synonym: "hypopharynx neoplasm" EXACT [] +synonym: "hypopharynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "hypopharynx tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of hypopharynx" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the hypopharynx" EXACT [NCIT:C3127] +synonym: "tumor of hypopharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3127] +synonym: "tumor of the hypopharynx" EXACT [NCIT:C3127] +xref: NCIT:C3127 {source="MONDO:equivalentTo"} +xref: SCTID:126686005 {source="MONDO:equivalentTo"} +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0020592 ! disorder of pharynx +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C3127"} ! pharynx neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001051 ! hypopharynx +relationship: disease_has_location UBERON:0001051 ! hypopharynx +property_value: exactMatch http://identifiers.org/snomedct/126686005 +property_value: exactMatch NCIT:C3127 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021360 +name: tumor of parathyroid gland +def: "A neoplasm (disease) that involves the parathyroid gland." [MONDO:patterns/location] +synonym: "neoplasm of parathyroid" EXACT [NCIT:C3313] +synonym: "neoplasm of parathyroid gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the parathyroid" EXACT [NCIT:C3313] +synonym: "neoplasm of the parathyroid gland" EXACT [NCIT:C3313] +synonym: "parathyroid gland neoplasm" EXACT [NCIT:C3313] +synonym: "parathyroid gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "parathyroid gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3313] +synonym: "parathyroid neoplasm" EXACT [NCIT:C3313] +synonym: "parathyroid tumor" EXACT [NCIT:C3313] +synonym: "tumor of parathyroid" EXACT [NCIT:C3313] +synonym: "tumor of parathyroid gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the parathyroid" EXACT [NCIT:C3313] +synonym: "tumor of the parathyroid gland" EXACT [NCIT:C3313] +xref: ICD9:239.7 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3313 {source="MONDO:equivalentTo"} +xref: SCTID:127020005 {source="MONDO:equivalentTo"} +is_a: MONDO:0001223 {source="MONDO:Redundant", source="NCIT:C3313"} ! parathyroid gland disorder +is_a: MONDO:0002082 ! endocrine gland neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +property_value: exactMatch http://identifiers.org/snomedct/127020005 +property_value: exactMatch NCIT:C3313 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021364 +name: neoplasm of oropharynx +def: "A neoplasm (disease) that involves the oropharynx." [MONDO:patterns/location] +synonym: "neoplasm of oropharynx" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the oropharynx" EXACT [NCIT:C3291] +synonym: "oropharyngeal neoplasm" EXACT [NCIT:C3291] +synonym: "oropharyngeal neoplasms" EXACT [NCIT:C3291] +synonym: "oropharyngeal tumor" EXACT [NCIT:C3291] +synonym: "oropharynx neoplasm" EXACT [] +synonym: "oropharynx neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "oropharynx tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of oropharynx" EXACT [MONDO:patterns/neoplasm, NCIT:C3291] +synonym: "tumor of the oropharynx" EXACT [NCIT:C3291] +xref: NCIT:C3291 {source="MONDO:equivalentTo"} +xref: SCTID:126809003 {source="MONDO:equivalentTo"} +xref: UMLS:C0029295 {source="MONDO:equivalentTo", source="NCIT:C3291"} +is_a: MONDO:0004335 {source="MONDO:Entailed"} ! digestive system disorder +is_a: MONDO:0005586 ! head and neck neoplasm +is_a: MONDO:0020592 ! disorder of pharynx +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C3291"} ! pharynx neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001729 ! oropharynx +relationship: disease_has_location UBERON:0001729 ! oropharynx +property_value: exactMatch http://identifiers.org/snomedct/126809003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029295 +property_value: exactMatch NCIT:C3291 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021366 +name: neoplasm of middle ear +def: "A neoplasm (disease) that involves the middle ear." [MONDO:patterns/location] +synonym: "middle Ear neoplasm" EXACT [NCIT:C4412] +synonym: "middle ear neoplasm" EXACT [] +synonym: "middle ear neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "middle Ear tumor" EXACT [NCIT:C4412] +synonym: "middle ear tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of middle ear" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the middle Ear" EXACT [NCIT:C4412] +synonym: "tumor of middle Ear" EXACT [NCIT:C4412] +synonym: "tumor of middle ear" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the middle Ear" EXACT [NCIT:C4412] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4412 {source="MONDO:equivalentTo"} +xref: SCTID:127006003 {source="MONDO:equivalentTo"} +is_a: MONDO:0003276 {source="MONDO:Redundant", source="NCIT:C4412"} ! middle ear disorder +is_a: MONDO:0021233 {source="MONDO:Redundant", source="NCIT:C4412"} ! ear neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch http://identifiers.org/snomedct/127006003 +property_value: exactMatch NCIT:C4412 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021368 +name: neoplasm of major salivary gland +def: "A neoplasm (disease) that involves the major salivary gland." [MONDO:patterns/location] +synonym: "major salivary gland neoplasm" EXACT [NCIT:C4407] +synonym: "major salivary gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "major salivary gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4407] +synonym: "neoplasm of major salivary gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the Major salivary gland" EXACT [NCIT:C4407] +synonym: "tumor of Major salivary gland" EXACT [NCIT:C4407] +synonym: "tumor of major salivary gland" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the Major salivary gland" EXACT [NCIT:C4407] +xref: NCIT:C4407 {source="MONDO:equivalentTo"} +xref: SCTID:126787005 {source="MONDO:equivalentTo"} +xref: UMLS:C0345599 {source="MONDO:equivalentTo", source="NCIT:C4407"} +is_a: MONDO:0021357 {source="MONDO:Redundant", source="NCIT:C4407"} ! tumor of salivary gland +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001829 ! major salivary gland +relationship: disease_has_location UBERON:0001829 ! major salivary gland +property_value: exactMatch http://identifiers.org/snomedct/126787005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345599 +property_value: exactMatch NCIT:C4407 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021370 +name: neoplasm of minor salivary gland +def: "A neoplasm (disease) that involves the minor salivary gland." [MONDO:patterns/location] +synonym: "minor salivary gland neoplasm" EXACT [NCIT:C4409] +synonym: "minor salivary gland neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "minor salivary gland tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4409] +synonym: "neoplasm of minor salivary gland" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the minor salivary gland" EXACT [NCIT:C4409] +synonym: "tumor of minor salivary gland" EXACT [MONDO:patterns/neoplasm, NCIT:C4409] +synonym: "tumor of the minor salivary gland" EXACT [NCIT:C4409] +xref: NCIT:C4409 {source="MONDO:equivalentTo"} +xref: SCTID:126798006 {source="MONDO:equivalentTo"} +xref: UMLS:C0345613 {source="NCIT:C4409", source="MONDO:equivalentTo"} +is_a: MONDO:0021357 {source="MONDO:Redundant", source="NCIT:C4409"} ! tumor of salivary gland +is_a: MONDO:0044992 ! mouth mucosa disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001830 ! minor salivary gland +relationship: disease_has_location UBERON:0001830 ! minor salivary gland +property_value: exactMatch http://identifiers.org/snomedct/126798006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345613 +property_value: exactMatch NCIT:C4409 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021372 +name: neoplasm of temporal lobe +def: "A neoplasm (disease) that involves the temporal lobe." [MONDO:patterns/location] +synonym: "neoplasm of temporal lobe" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the temporal lobe" EXACT [NCIT:C5567] +synonym: "temporal lobe neoplasm" EXACT [NCIT:C5567] +synonym: "temporal lobe neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "temporal lobe tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5567] +synonym: "tumor of temporal lobe" EXACT [MONDO:patterns/neoplasm, NCIT:C5567] +synonym: "tumor of the temporal lobe" EXACT [NCIT:C5567] +xref: NCIT:C5567 {source="MONDO:equivalentTo"} +xref: SCTID:126955002 {source="MONDO:equivalentTo"} +xref: UMLS:C1263887 {source="MONDO:equivalentTo", source="NCIT:C5567"} +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C5567"} ! neoplasm of cerebral hemisphere +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001871 ! temporal lobe +relationship: disease_has_location UBERON:0001871 ! temporal lobe +property_value: exactMatch http://identifiers.org/snomedct/126955002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263887 +property_value: exactMatch NCIT:C5567 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021373 +name: neoplasm of parietal lobe +def: "A neoplasm (disease) that involves the parietal lobe." [MONDO:patterns/location] +synonym: "neoplasm of parietal lobe" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the parietal lobe" EXACT [NCIT:C5573] +synonym: "parietal lobe neoplasm" EXACT [] +synonym: "parietal lobe neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "parietal lobe tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C5573] +synonym: "tumor of parietal lobe" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the parietal lobe" EXACT [NCIT:C5573] +xref: NCIT:C5573 {source="MONDO:equivalentTo"} +xref: SCTID:126956001 {source="MONDO:equivalentTo"} +xref: UMLS:C1263888 {source="NCIT:C5573", source="MONDO:equivalentTo"} +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C5573"} ! neoplasm of cerebral hemisphere +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001872 ! parietal lobe +relationship: disease_has_location UBERON:0001872 ! parietal lobe +property_value: exactMatch http://identifiers.org/snomedct/126956001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263888 +property_value: exactMatch NCIT:C5573 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021374 +name: neoplasm of cerebral hemisphere +def: "A neoplasm involving a cerebral hemisphere." [MONDO:patterns/neoplasm] +synonym: "cerebral hemisphere neoplasm" EXACT [] +synonym: "cerebral hemisphere tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "cerebral hemispheric neoplasm" EXACT [NCIT:C4874] +synonym: "cerebral hemispheric tumor" EXACT [NCIT:C4874] +synonym: "cerebral neoplasm" EXACT [NCIT:C4874] +synonym: "cerebral neoplasms" EXACT [NCIT:C4874] +synonym: "cerebral tumor" EXACT [NCIT:C4874] +synonym: "neoplasm of cerebral hemisphere" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of cerebral hemispheres" EXACT [NCIT:C4874] +synonym: "neoplasm of cerebrum" EXACT [NCIT:C4874] +synonym: "neoplasm of telencephalon" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the cerebral hemispheres" EXACT [NCIT:C4874] +synonym: "neoplasm of the cerebrum" EXACT [NCIT:C4874] +synonym: "telencephalon neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "telencephalon tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of cerebral hemisphere" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of cerebral hemispheres" EXACT [NCIT:C4874] +synonym: "tumor of cerebrum" EXACT [NCIT:C4874] +synonym: "tumor of telencephalon" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the cerebral hemispheres" EXACT [NCIT:C4874] +synonym: "tumor of the cerebrum" EXACT [NCIT:C4874] +xref: NCIT:C4874 {source="MONDO:equivalentTo"} +xref: SCTID:126953009 {source="MONDO:equivalentTo"} +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C4874/inferred"} ! brain neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001869 ! cerebral hemisphere +relationship: disease_has_location UBERON:0001869 ! cerebral hemisphere +property_value: exactMatch http://identifiers.org/snomedct/126953009 +property_value: exactMatch NCIT:C4874 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021375 +name: tumor of duodenum +def: "A neoplasm (disease) that involves the duodenum." [MONDO:patterns/location] +synonym: "duodenal neoplasm" EXACT [NCIT:C2995] +synonym: "duodenal tumor" EXACT [NCIT:C2995] +synonym: "duodenum neoplasm" EXACT [] +synonym: "duodenum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "duodenum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of duodenum" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the duodenum" EXACT [NCIT:C2995] +synonym: "tumor of duodenum" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the duodenum" EXACT [NCIT:C2995] +xref: NCIT:C2995 {source="MONDO:equivalentTo"} +xref: SCTID:126833009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002866 {source="MONDO:Redundant"} ! duodenal disorder +is_a: MONDO:0004251 {source="MONDO:Redundant", source="NCIT:C2995"} ! small intestine neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: exactMatch http://identifiers.org/snomedct/126833009 +property_value: exactMatch NCIT:C2995 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021378 +name: neoplasm of endocardium +def: "A neoplasm (disease) that involves the endocardium." [MONDO:patterns/location] +synonym: "endocardial neoplasm" EXACT [NCIT:C5346] +synonym: "endocardial tumor" EXACT [NCIT:C5346] +synonym: "endocardium neoplasm" EXACT [] +synonym: "endocardium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "endocardium tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of endocardium" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the endocardium" EXACT [NCIT:C5346] +synonym: "tumor of endocardium" EXACT [MONDO:patterns/neoplasm, NCIT:C5346] +synonym: "tumor of the endocardium" EXACT [NCIT:C5346] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5346 {source="MONDO:equivalentTo"} +xref: SCTID:126731002 {source="MONDO:equivalentTo"} +xref: UMLS:C1290401 {source="MONDO:equivalentTo", source="NCIT:C5346"} +is_a: MONDO:0000470 ! endocardium disorder +is_a: MONDO:0021209 {source="MONDO:Redundant", source="NCIT:C5346"} ! heart neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002165 ! endocardium +property_value: exactMatch http://identifiers.org/snomedct/126731002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290401 +property_value: exactMatch NCIT:C5346 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021379 +name: neoplasm of epicardium +def: "A neoplasm (disease) that involves the epicardium." [MONDO:patterns/location] +synonym: "epicardial neoplasm" EXACT [NCIT:C5347] +synonym: "epicardial tumor" EXACT [NCIT:C5347] +synonym: "epicardium neoplasm" EXACT [] +synonym: "epicardium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "epicardium tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of epicardium" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the epicardium" EXACT [NCIT:C5347] +synonym: "tumor of epicardium" EXACT [MONDO:patterns/neoplasm, NCIT:C5347] +synonym: "tumor of the epicardium" EXACT [NCIT:C5347] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5347 {source="MONDO:equivalentTo"} +xref: SCTID:126733004 {source="MONDO:equivalentTo"} +xref: UMLS:C1290403 {source="MONDO:equivalentTo", source="NCIT:C5347"} +is_a: MONDO:0021209 {source="MONDO:Redundant", source="NCIT:C5347"} ! heart neoplasm +is_a: MONDO:0021381 {source="MONDO:Redundant"} ! neoplasm of pericardium +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002348 ! epicardium +relationship: disease_has_location UBERON:0002348 ! epicardium +property_value: exactMatch http://identifiers.org/snomedct/126733004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290403 +property_value: exactMatch NCIT:C5347 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021380 +name: neoplasm of myocardium +def: "A neoplasm (disease) that involves the myocardium." [MONDO:patterns/location] +synonym: "myocardial neoplasm" EXACT [NCIT:C5349] +synonym: "myocardial tumor" EXACT [NCIT:C5349] +synonym: "myocardium neoplasm" EXACT [] +synonym: "myocardium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "myocardium tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of myocardium" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the myocardium" EXACT [NCIT:C5349] +synonym: "tumor of myocardium" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the myocardium" EXACT [NCIT:C5349] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C5349 {source="MONDO:equivalentTo"} +xref: SCTID:126732009 {source="MONDO:equivalentTo"} +xref: UMLS:C1290402 {source="MONDO:equivalentTo", source="NCIT:C5349"} +is_a: MONDO:0021209 {source="MONDO:Redundant", source="NCIT:C5349"} ! heart neoplasm +is_a: MONDO:0024643 ! myocardial disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002349 ! myocardium +property_value: exactMatch http://identifiers.org/snomedct/126732009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290402 +property_value: exactMatch NCIT:C5349 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021381 +name: neoplasm of pericardium +def: "A neoplasm (disease) that involves the pericardium." [MONDO:patterns/location] +synonym: "neoplasm of pericardium" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the pericardium" EXACT [NCIT:C4651] +synonym: "pericardial neoplasm" EXACT [NCIT:C4651] +synonym: "pericardial tumor" EXACT [NCIT:C4651] +synonym: "pericardium neoplasm" EXACT [] +synonym: "pericardium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "pericardium tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of pericardium" EXACT [MONDO:patterns/neoplasm, NCIT:C4651] +synonym: "tumor of the pericardium" EXACT [NCIT:C4651] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4651 {source="MONDO:equivalentTo"} +xref: SCTID:126734005 {source="MONDO:equivalentTo"} +is_a: MONDO:0000474 ! pericardium disorder +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C4651/inferred"} ! neoplasm of thorax +is_a: MONDO:0024757 ! cardiovascular neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002407 ! pericardium +property_value: exactMatch http://identifiers.org/snomedct/126734005 +property_value: exactMatch NCIT:C4651 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021383 +name: neoplasm of floor of mouth +def: "A neoplasm (disease) that involves the mouth floor." [MONDO:patterns/location] +synonym: "floor of mouth neoplasm" EXACT [NCIT:C4401] +synonym: "floor of mouth tumor" EXACT [NCIT:C4401] +synonym: "floor of the mouth neoplasm" EXACT [NCIT:C4401] +synonym: "floor of the mouth tumor" EXACT [NCIT:C4401] +synonym: "mouth floor neoplasm" EXACT [] +synonym: "mouth floor neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "mouth floor tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of mouth floor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the floor of the mouth" EXACT [NCIT:C4401] +synonym: "tumor of floor of mouth" EXACT [NCIT:C4401] +synonym: "tumor of mouth floor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the floor of the mouth" EXACT [NCIT:C4401] +xref: NCIT:C4401 {source="MONDO:equivalentTo"} +xref: SCTID:126799003 {source="MONDO:equivalentTo"} +xref: UMLS:C0345538 {source="MONDO:equivalentTo", source="NCIT:C4401"} +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C4401/inferred"} ! head and neck neoplasm +is_a: MONDO:0006858 {source="MONDO:Redundant", source="NCIT:C4401/inferred"} ! mouth disorder +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003679 ! mouth floor +relationship: disease_has_location UBERON:0003679 ! mouth floor +property_value: exactMatch http://identifiers.org/snomedct/126799003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345538 +property_value: exactMatch NCIT:C4401 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021385 +name: extrahepatic bile duct neoplasm +def: "A benign or malignant neoplasm that affects the extrahepatic bile ducts. Representative examples include adenoma and adenocarcinoma." [NCIT:C4441] +synonym: "extrahepatic bile duct neoplasm" EXACT [NCIT:C4441] +synonym: "extrahepatic bile duct neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "extrahepatic bile duct tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4441] +synonym: "neoplasm of extrahepatic bile duct" EXACT [MONDO:patterns/neoplasm, NCIT:C4441] +synonym: "neoplasm of the extrahepatic bile duct" EXACT [NCIT:C4441] +synonym: "tumor of extrahepatic bile duct" EXACT [MONDO:patterns/neoplasm, NCIT:C4441] +synonym: "tumor of the extrahepatic bile duct" EXACT [NCIT:C4441] +xref: NCIT:C4441 {source="MONDO:equivalentTo"} +xref: SCTID:126855001 {source="MONDO:equivalentTo"} +xref: UMLS:C0345913 {source="NCIT:C4441", source="MONDO:equivalentTo"} +is_a: MONDO:0021662 {source="MONDO:Redundant", source="NCIT:C4441"} ! bile duct neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003703 ! extrahepatic bile duct +relationship: disease_has_location UBERON:0003703 ! extrahepatic bile duct +property_value: exactMatch http://identifiers.org/snomedct/126855001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345913 +property_value: exactMatch NCIT:C4441 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3673 xsd:string + +[Term] +id: MONDO:0021386 +name: neoplasm of mediastinum +def: "A neoplasm (disease) that involves the mediastinum." [MONDO:patterns/location] +synonym: "mediastinal neoplasm" EXACT [NCIT:C3221] +synonym: "mediastinal tumor" EXACT [NCIT:C3221] +synonym: "mediastinum neoplasm" EXACT [] +synonym: "mediastinum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "mediastinum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of mediastinum" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the mediastinum" EXACT [NCIT:C3221] +synonym: "tumor of mediastinum" EXACT [MONDO:patterns/neoplasm, NCIT:C3221] +synonym: "tumor of the mediastinum" EXACT [NCIT:C3221] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3221 {source="MONDO:equivalentTo"} +xref: SCTID:126725000 {source="MONDO:equivalentTo"} +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C3221"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +relationship: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch http://identifiers.org/snomedct/126725000 +property_value: exactMatch NCIT:C3221 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021388 +name: neoplasm of chest wall +def: "A neoplasm (disease) that involves the chest wall." [MONDO:patterns/location] +synonym: "chest wall neoplasm" EXACT [NCIT:C4929] +synonym: "chest wall neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "chest wall tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C4929] +synonym: "neoplasm of chest wall" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the chest wall" EXACT [NCIT:C4929] +synonym: "tumor of chest wall" EXACT [MONDO:patterns/neoplasm, NCIT:C4929] +synonym: "tumor of the chest wall" EXACT [NCIT:C4929] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4929 {source="MONDO:equivalentTo"} +xref: SCTID:126640008 {source="MONDO:equivalentTo"} +xref: UMLS:C1290309 {source="NCIT:C4929", source="MONDO:equivalentTo"} +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C4929"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0016435 ! chest wall +relationship: disease_has_location UBERON:0016435 ! chest wall +property_value: exactMatch http://identifiers.org/snomedct/126640008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290309 +property_value: exactMatch NCIT:C4929 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021427 +name: squamous cell carcinoma of lip +def: "A squamous cell carcinoma that involves the lip." [MONDO:patterns/location] +subset: ordo_disease +synonym: "lip scc" EXACT [NCIT:C4042] +synonym: "lip squamous cell carcinoma" EXACT [MONDO:patterns/location, NCIT:C4042] +synonym: "scc of Lip" EXACT [NCIT:C4042] +synonym: "scc of the Lip" EXACT [NCIT:C4042] +synonym: "squamous cell carcinoma of the Lip" EXACT [NCIT:C4042] +xref: NCIT:C4042 {source="MONDO:equivalentTo"} +xref: Orphanet:502366 {source="MONDO:equivalentTo"} +xref: SCTID:255071008 {source="MONDO:equivalentTo"} +xref: UMLS:C0280302 {source="NCIT:C4042", source="MONDO:equivalentTo"} +is_a: MONDO:0004958 {source="MONDO:Redundant"} ! oral cavity squamous cell carcinoma +is_a: MONDO:0021333 {source="MONDO:Redundant", source="NCIT:C4042"} ! carcinoma of lip +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001833 ! lip +property_value: exactMatch http://identifiers.org/snomedct/255071008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280302 +property_value: exactMatch NCIT:C4042 +property_value: exactMatch Orphanet:502366 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0021429 +name: squamous cell carcinoma of floor of mouth +def: "A squamous cell carcinoma that involves the mouth floor." [MONDO:patterns/location] +synonym: "floor of mouth scc" EXACT [NCIT:C4041] +synonym: "floor of mouth squamous cell carcinoma" EXACT [NCIT:C4041] +synonym: "mouth floor squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "scc of floor of mouth" EXACT [NCIT:C4041] +synonym: "scc of the floor of mouth" EXACT [NCIT:C4041] +synonym: "squamous cell carcinoma of the floor of mouth" EXACT [NCIT:C4041] +xref: NCIT:C4041 {source="MONDO:equivalentTo"} +xref: SCTID:276954004 {source="MONDO:equivalentTo"} +xref: UMLS:C0280300 {source="NCIT:C4041", source="MONDO:equivalentTo"} +is_a: MONDO:0004958 {source="MONDO:Redundant", source="NCIT:C4041"} ! oral cavity squamous cell carcinoma +is_a: MONDO:0021343 {source="MONDO:Redundant", source="NCIT:C4041"} ! carcinoma of floor of mouth +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0003679 ! mouth floor +property_value: exactMatch http://identifiers.org/snomedct/276954004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280300 +property_value: exactMatch NCIT:C4041 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0021439 +name: benign neoplasm of pituitary gland +def: "A benign neoplasm that involves the pituitary gland." [MONDO:patterns/location] +synonym: "benign neoplasm of pituitary" EXACT [NCIT:C4782] +synonym: "benign neoplasm of the pituitary" EXACT [NCIT:C4782] +synonym: "benign neoplasm of the pituitary gland" EXACT [NCIT:C4782] +synonym: "benign pituitary gland neoplasm" EXACT [NCIT:C4782] +synonym: "benign pituitary gland tumor" EXACT [NCIT:C4782] +synonym: "benign pituitary neoplasm" EXACT [NCIT:C4782] +synonym: "benign pituitary tumor" EXACT [NCIT:C4782] +synonym: "benign tumor of pituitary" EXACT [NCIT:C4782] +synonym: "benign tumor of pituitary gland" EXACT [NCIT:C4782] +synonym: "benign tumor of the pituitary" EXACT [NCIT:C4782] +synonym: "benign tumor of the pituitary gland" EXACT [NCIT:C4782] +synonym: "pituitary gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "pituitary neoplasms, benign" EXACT [NCIT:C4782] +synonym: "pituitary tumor, benign" EXACT [NCIT:C4782] +xref: DOID:60009 {source="MONDO:equivalentTo"} +xref: ICD10CM:D35.2 {source="MONDO:equivalentTo"} +xref: NCIT:C4782 {source="MONDO:equivalentTo"} +xref: SCTID:92296004 {source="MONDO:equivalentTo"} +xref: UMLS:C0496901 {source="NCIT:C4782", source="MONDO:equivalentTo"} +is_a: MONDO:0000627 {source="MONDO:Redundant"} ! benign endocrine neoplasm +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0017611 ! pituitary tumor +is_a: MONDO:0021451 {source="MONDO:Redundant", source="NCIT:C4782/inferred"} ! benign neoplasm of brain +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +property_value: exactMatch DOID:60009 +property_value: exactMatch http://identifiers.org/snomedct/92296004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496901 +property_value: exactMatch https://icd.codes/icd10cm/D35.2 +property_value: exactMatch NCIT:C4782 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021440 +name: benign neoplasm of skin +def: "A benign neoplasm that involves the zone of skin." [MONDO:patterns/location] +synonym: "benign cutaneous neoplasm" EXACT [NCIT:C2896] +synonym: "benign cutaneous tumor" EXACT [NCIT:C2896] +synonym: "benign neoplasm of the skin" EXACT [NCIT:C2896] +synonym: "benign skin neoplasm" EXACT [NCIT:C2896] +synonym: "benign skin tumor" EXACT [NCIT:C2896] +synonym: "benign tumor of skin" EXACT [NCIT:C2896] +synonym: "benign tumor of the skin" EXACT [NCIT:C2896] +synonym: "skin neoplasms, benign" EXACT [NCIT:C2896] +synonym: "zone of skin benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:216.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:216.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C2896 {source="MONDO:equivalentTo"} +xref: SCTID:92384009 {source="MONDO:equivalentTo"} +xref: UMLS:C0004998 {source="MONDO:equivalentTo", source="NCIT:C2896"} +is_a: MONDO:0000652 ! integumentary system benign neoplasm +is_a: MONDO:0002531 {source="MONDO:Redundant", source="NCIT:C2896"} ! skin neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch http://identifiers.org/snomedct/92384009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004998 +property_value: exactMatch NCIT:C2896 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021441 +name: benign neoplasm of exocrine pancreas +def: "A benign neoplasm that involves the exocrine pancreas." [MONDO:patterns/location] +synonym: "benign exocrine pancreas neoplasm" EXACT [NCIT:C4613] +synonym: "benign exocrine pancreas tumor" EXACT [NCIT:C4613] +synonym: "benign exocrine pancreatic neoplasm" EXACT [NCIT:C4613] +synonym: "benign neoplasm of the exocrine pancreas" EXACT [NCIT:C4613] +synonym: "benign tumor of exocrine pancreas" EXACT [NCIT:C4613] +synonym: "benign tumor of the exocrine pancreas" EXACT [NCIT:C4613] +synonym: "exocrine pancreas benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4613 {source="MONDO:equivalentTo"} +xref: SCTID:271956003 {source="MONDO:equivalentTo"} +xref: UMLS:C0347285 {source="MONDO:equivalentTo", source="NCIT:C4613"} +is_a: MONDO:0021076 {source="MONDO:Redundant", source="NCIT:C4613"} ! pancreatic exocrine neoplasm +is_a: MONDO:0021470 {source="MONDO:Redundant", source="NCIT:C4613"} ! benign neoplasm of pancreas +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000017 ! exocrine pancreas +property_value: exactMatch http://identifiers.org/snomedct/271956003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347285 +property_value: exactMatch NCIT:C4613 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021443 +name: benign neoplasm of lymph node +def: "A benign neoplasm that involves the lymph node." [MONDO:patterns/location] +synonym: "benign lymph node neoplasm" EXACT [NCIT:C3636] +synonym: "benign lymph node tumor" EXACT [NCIT:C3636] +synonym: "benign neoplasm of the lymph node" EXACT [NCIT:C3636] +synonym: "benign tumor of lymph node" EXACT [NCIT:C3636] +synonym: "benign tumor of the lymph node" EXACT [NCIT:C3636] +synonym: "lymph node benign neoplasm" EXACT [MONDO:patterns/location] +xref: DOID:0080617 {source="MONDO:equivalentTo"} +xref: ICD9:229.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3636 {source="MONDO:equivalentTo"} +xref: SCTID:92197001 {source="MONDO:equivalentTo"} +xref: UMLS:C0154054 {source="MONDO:equivalentTo", source="NCIT:C3636"} +is_a: MONDO:0000630 ! immune system organ benign neoplasm +is_a: MONDO:0024339 ! lymph node neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000029 ! lymph node +property_value: exactMatch DOID:0080617 +property_value: exactMatch http://identifiers.org/snomedct/92197001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154054 +property_value: exactMatch NCIT:C3636 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021444 +name: benign neoplasm of large intestine +def: "A benign neoplasm that involves the large intestine." [MONDO:patterns/location] +synonym: "benign colorectal neoplasm" EXACT [NCIT:C4610] +synonym: "benign colorectal neoplasms" EXACT [NCIT:C4610] +synonym: "benign colorectal tumor" EXACT [NCIT:C4610] +synonym: "benign colorectal tumors" EXACT [NCIT:C4610] +synonym: "benign large bowel neoplasm" EXACT [NCIT:C4610] +synonym: "benign large bowel tumor" EXACT [NCIT:C4610] +synonym: "benign large intestine neoplasm" EXACT [NCIT:C4610] +synonym: "benign large intestine tumor" EXACT [NCIT:C4610] +synonym: "benign neoplasm of large bowel" EXACT [NCIT:C4610] +synonym: "benign neoplasm of the large bowel" EXACT [NCIT:C4610] +synonym: "benign neoplasm of the large intestine" EXACT [NCIT:C4610] +synonym: "benign tumor of large bowel" EXACT [NCIT:C4610] +synonym: "benign tumor of large intestine" EXACT [NCIT:C4610] +synonym: "benign tumor of the large bowel" EXACT [NCIT:C4610] +synonym: "benign tumor of the large intestine" EXACT [NCIT:C4610] +synonym: "colorectal neoplasms, benign" EXACT [NCIT:C4610] +synonym: "colorectal tumors, benign" EXACT [NCIT:C4610] +synonym: "large intestine benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "neoplasms, colorectal, benign" EXACT [NCIT:C4610] +synonym: "tumors, colorectal, benign" EXACT [NCIT:C4610] +xref: NCIT:C4610 {source="MONDO:equivalentTo"} +xref: SCTID:92170008 {source="MONDO:equivalentTo"} +xref: UMLS:C0347272 {source="MONDO:equivalentTo", source="NCIT:C4610"} +is_a: MONDO:0003062 {source="MONDO:Redundant", source="NCIT:C4610"} ! intestinal benign neoplasm +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000059 ! large intestine +property_value: exactMatch http://identifiers.org/snomedct/92170008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347272 +property_value: exactMatch NCIT:C4610 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021445 +name: benign neoplasm of oral cavity +def: "A benign neoplasm that involves the oral cavity." [MONDO:patterns/location] +synonym: "benign mouth neoplasm" EXACT [NCIT:C7607] +synonym: "benign mouth tumor" EXACT [NCIT:C7607] +synonym: "benign neoplasm of mouth" EXACT [NCIT:C7607] +synonym: "benign neoplasm of the mouth" EXACT [NCIT:C7607] +synonym: "benign neoplasm of the oral cavity" EXACT [NCIT:C7607] +synonym: "benign oral cavity neoplasm" EXACT [NCIT:C7607] +synonym: "benign oral cavity tumor" EXACT [NCIT:C7607] +synonym: "benign tumor of mouth" EXACT [NCIT:C7607] +synonym: "benign tumor of oral cavity" EXACT [NCIT:C7607] +synonym: "benign tumor of the mouth" EXACT [NCIT:C7607] +synonym: "benign tumor of the oral cavity" EXACT [NCIT:C7607] +synonym: "oral cavity benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C7607 {source="MONDO:equivalentTo"} +xref: SCTID:419645003 {source="MONDO:equivalentTo"} +xref: UMLS:C0347197 {source="MONDO:equivalentTo", source="NCIT:C7607"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0021245 {source="MONDO:Redundant", source="NCIT:C7607"} ! oral cavity neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000167 ! oral cavity +property_value: exactMatch http://identifiers.org/snomedct/419645003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347197 +property_value: exactMatch NCIT:C7607 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021446 +name: benign neoplasm of epiglottis +def: "A benign neoplasm that involves the epiglottis." [MONDO:patterns/location] +synonym: "benign epiglottic neoplasm" EXACT [NCIT:C4606] +synonym: "benign epiglottic tumor" EXACT [NCIT:C4606] +synonym: "benign Epiglottis neoplasm" EXACT [NCIT:C4606] +synonym: "benign Epiglottis tumor" EXACT [NCIT:C4606] +synonym: "benign neoplasm of the Epiglottis" EXACT [NCIT:C4606] +synonym: "benign tumor of Epiglottis" EXACT [NCIT:C4606] +synonym: "benign tumor of the Epiglottis" EXACT [NCIT:C4606] +synonym: "epiglottis benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4606 {source="MONDO:equivalentTo"} +xref: SCTID:92089006 {source="MONDO:equivalentTo"} +xref: UMLS:C0347236 {source="NCIT:C4606", source="MONDO:equivalentTo"} +is_a: MONDO:0002354 {source="MONDO:Redundant", source="NCIT:C4606/inferred"} ! benign laryngeal neoplasm +is_a: MONDO:0004109 {source="MONDO:Redundant", source="NCIT:C4606"} ! epiglottis neoplasm +is_a: MONDO:0021461 ! benign neoplasm of hypopharynx +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000388 ! epiglottis +property_value: exactMatch http://identifiers.org/snomedct/92089006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347236 +property_value: exactMatch NCIT:C4606 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021447 +name: benign neoplasm of testis +def: "A benign neoplasm that involves the testis." [MONDO:patterns/location] +synonym: "benign neoplasm of the testis" EXACT [NCIT:C3612] +synonym: "benign testicular neoplasm" EXACT [NCIT:C3612] +synonym: "benign testicular tumor" EXACT [NCIT:C3612] +synonym: "benign tumor of testis" EXACT [NCIT:C3612] +synonym: "benign tumor of the testis" EXACT [NCIT:C3612] +synonym: "testis benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:222.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3612 {source="MONDO:equivalentTo"} +xref: SCTID:92428008 {source="MONDO:equivalentTo"} +xref: UMLS:C0154007 {source="MONDO:equivalentTo", source="NCIT:C3612"} +is_a: MONDO:0000625 ! benign male reproductive system neoplasm +is_a: MONDO:0021348 {source="MONDO:Redundant", source="NCIT:C3612"} ! neoplasm of testis +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000473 ! testis +property_value: exactMatch http://identifiers.org/snomedct/92428008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154007 +property_value: exactMatch NCIT:C3612 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021449 +name: benign neoplasm of stomach +def: "A benign neoplasm that involves the stomach." [MONDO:patterns/location] +synonym: "benign gastric neoplasm" EXACT [NCIT:C3599] +synonym: "benign gastric tumor" EXACT [NCIT:C3599] +synonym: "benign gastric tumors" EXACT [NCIT:C3599] +synonym: "benign neoplasm of the stomach" EXACT [NCIT:C3599] +synonym: "benign stomach neoplasms" EXACT [NCIT:C3599] +synonym: "benign stomach tumors" EXACT [NCIT:C3599] +synonym: "benign tumor of stomach" EXACT [NCIT:C3599] +synonym: "benign tumor of the stomach" EXACT [NCIT:C3599] +synonym: "benign tumors of stomach" EXACT [NCIT:C3599] +synonym: "benign tumors of the stomach" EXACT [NCIT:C3599] +synonym: "gastric neoplasms, benign" EXACT [NCIT:C3599] +synonym: "gastric tumors, benign" EXACT [NCIT:C3599] +synonym: "stomach benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "stomach neoplasms, benign" EXACT [NCIT:C3599] +synonym: "stomach tumors, benign" EXACT [NCIT:C3599] +xref: ICD10CM:D13.1 {source="MONDO:equivalentTo"} +xref: ICD9:211.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3599 {source="MONDO:equivalentTo"} +xref: SCTID:92411005 {source="MONDO:equivalentTo"} +xref: UMLS:C0153943 {source="MONDO:equivalentTo", source="NCIT:C3599"} +is_a: MONDO:0000385 {source="MONDO:Redundant", source="NCIT:C3599"} ! benign digestive system neoplasm +is_a: MONDO:0021085 {source="MONDO:Redundant", source="NCIT:C3599"} ! gastric neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch http://identifiers.org/snomedct/92411005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153943 +property_value: exactMatch https://icd.codes/icd10cm/D13.1 +property_value: exactMatch NCIT:C3599 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021450 +name: benign neoplasm of heart +def: "A benign neoplasm that involves the heart." [MONDO:patterns/location] +synonym: "benign Cardiac neoplasm" EXACT [NCIT:C3605] +synonym: "benign Cardiac tumor" EXACT [NCIT:C3605] +synonym: "benign heart neoplasm" EXACT [NCIT:C3605] +synonym: "benign heart tumor" EXACT [NCIT:C3605] +synonym: "benign neoplasm of the heart" EXACT [NCIT:C3605] +synonym: "benign tumor of heart" EXACT [NCIT:C3605] +synonym: "benign tumor of the heart" EXACT [NCIT:C3605] +synonym: "heart benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D15.1 {source="MONDO:equivalentTo"} +xref: ICD9:212.7 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3605 {source="MONDO:equivalentTo"} +xref: SCTID:92132009 {source="MONDO:equivalentTo"} +xref: UMLS:C0153957 {source="NCIT:C3605", source="MONDO:equivalentTo"} +is_a: MONDO:0000629 ! cardiovascular organ benign neoplasm +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C3605"} ! thoracic benign neoplasm +is_a: MONDO:0021209 {source="MONDO:Redundant", source="NCIT:C3605"} ! heart neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000948 ! heart +property_value: exactMatch http://identifiers.org/snomedct/92132009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153957 +property_value: exactMatch https://icd.codes/icd10cm/D15.1 +property_value: exactMatch NCIT:C3605 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021451 +name: benign neoplasm of brain +def: "A benign neoplasm that involves the brain." [MONDO:patterns/location] +synonym: "benign brain neoplasm" EXACT [NCIT:C4781] +synonym: "benign brain tumor" EXACT [NCIT:C4781] +synonym: "benign neoplasm of the brain" EXACT [NCIT:C4781] +synonym: "benign tumor of brain" EXACT [NCIT:C4781] +synonym: "benign tumor of the brain" EXACT [NCIT:C4781] +synonym: "brain benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "brain neoplasms, benign" EXACT [NCIT:C4781] +xref: EFO:1000107 {source="MONDO:equivalentTo"} +xref: ICD9:225.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4781 {source="MONDO:equivalentTo"} +xref: SCTID:92030004 {source="MONDO:equivalentTo"} +is_a: MONDO:0000628 ! central nervous system organ benign neoplasm +is_a: MONDO:0021211 {source="MONDO:Redundant", source="NCIT:C4781"} ! brain neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch http://identifiers.org/snomedct/92030004 +property_value: exactMatch NCIT:C4781 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021452 +name: benign neoplasm of cornea +def: "A benign neoplasm that involves the cornea." [MONDO:patterns/location] +synonym: "benign cornea neoplasm" EXACT [NCIT:C3623] +synonym: "benign cornea tumor" EXACT [NCIT:C3623] +synonym: "benign corneal neoplasm" EXACT [NCIT:C3623] +synonym: "benign corneal tumor" EXACT [NCIT:C3623] +synonym: "benign neoplasm of the cornea" EXACT [NCIT:C3623] +synonym: "benign tumor of cornea" EXACT [NCIT:C3623] +synonym: "benign tumor of the cornea" EXACT [NCIT:C3623] +synonym: "cornea benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3623 {source="MONDO:equivalentTo"} +xref: SCTID:92070006 {source="MONDO:equivalentTo"} +xref: UMLS:C0154026 {source="MONDO:equivalentTo", source="NCIT:C3623"} +is_a: MONDO:0000652 ! integumentary system benign neoplasm +is_a: MONDO:0021238 {source="MONDO:Redundant", source="NCIT:C3623"} ! cornea neoplasm +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C3623"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch http://identifiers.org/snomedct/92070006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154026 +property_value: exactMatch NCIT:C3623 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021453 +name: benign neoplasm of retina +def: "A benign neoplasm that involves the retina." [MONDO:patterns/location] +synonym: "benign neoplasm of the retina" EXACT [NCIT:C3624] +synonym: "benign retina neoplasm" EXACT [NCIT:C3624] +synonym: "benign retina tumor" EXACT [NCIT:C3624] +synonym: "benign retinal neoplasm" EXACT [NCIT:C3624] +synonym: "benign retinal tumor" EXACT [NCIT:C3624] +synonym: "benign tumor of retina" EXACT [NCIT:C3624] +synonym: "benign tumor of the retina" EXACT [NCIT:C3624] +synonym: "retina benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.5 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3624 {source="MONDO:equivalentTo"} +xref: SCTID:92321003 {source="MONDO:equivalentTo"} +xref: UMLS:C0154027 {source="MONDO:equivalentTo", source="NCIT:C3624"} +is_a: MONDO:0021231 {source="MONDO:Redundant", source="NCIT:C3624"} ! retina neoplasm +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C3624"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch http://identifiers.org/snomedct/92321003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154027 +property_value: exactMatch NCIT:C3624 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021454 +name: benign neoplasm of eye +def: "A benign neoplasm that involves the eye." [MONDO:patterns/location] +synonym: "benign eye neoplasm" EXACT [NCIT:C4780] +synonym: "benign eye tumor" EXACT [NCIT:C4780] +synonym: "benign neoplasm of the eye" EXACT [NCIT:C4780] +synonym: "benign ocular neoplasm" EXACT [NCIT:C4780] +synonym: "benign ocular tumor" EXACT [NCIT:C4780] +synonym: "benign tumor of eye" EXACT [NCIT:C4780] +synonym: "benign tumor of the eye" EXACT [NCIT:C4780] +synonym: "eye benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:224.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:224.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4780 {source="MONDO:equivalentTo"} +xref: SCTID:92097004 {source="MONDO:equivalentTo"} +xref: UMLS:C0496897 {source="NCIT:C4780", source="MONDO:equivalentTo"} +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0021220 {source="MONDO:Redundant", source="NCIT:C4780"} ! eye neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0010230 ! eyeball of camera-type eye +property_value: exactMatch http://identifiers.org/snomedct/92097004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496897 +property_value: exactMatch NCIT:C4780 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021455 +name: benign neoplasm of neck +def: "A benign neoplasm that involves the neck." [MONDO:patterns/location] +synonym: "benign neck neoplasm" EXACT [NCIT:C4884] +synonym: "benign neck tumor" EXACT [NCIT:C4884] +synonym: "benign neoplasm of the neck" EXACT [NCIT:C4884] +synonym: "benign tumor of neck" EXACT [NCIT:C4884] +synonym: "benign tumor of the neck" EXACT [NCIT:C4884] +synonym: "neck benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:229.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4884 {source="MONDO:equivalentTo"} +xref: SCTID:92246000 {source="MONDO:equivalentTo"} +xref: UMLS:C0684815 {source="MONDO:equivalentTo", source="NCIT:C4884"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0021351 {source="MONDO:Redundant", source="NCIT:C4884"} ! neoplasm of neck +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000974 ! neck +property_value: exactMatch http://identifiers.org/snomedct/92246000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684815 +property_value: exactMatch NCIT:C4884 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021456 +name: benign neoplasm of sternum +def: "A benign neoplasm that involves the sternum." [MONDO:patterns/location] +synonym: "benign neoplasm of the sternum" EXACT [NCIT:C8416] +synonym: "benign sternal neoplasm" EXACT [NCIT:C8416] +synonym: "benign sternal tumor" EXACT [NCIT:C8416] +synonym: "benign tumor of sternum" EXACT [NCIT:C8416] +synonym: "benign tumor of the sternum" EXACT [NCIT:C8416] +synonym: "sternum benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8416 {source="MONDO:equivalentTo"} +xref: SCTID:92410006 {source="MONDO:equivalentTo"} +xref: UMLS:C0347312 {source="MONDO:equivalentTo", source="NCIT:C8416"} +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C8416"} ! thoracic benign neoplasm +is_a: MONDO:0000636 ! musculoskeletal system benign neoplasm +is_a: MONDO:0021578 {source="MONDO:Redundant", source="NCIT:C8416"} ! sternal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000975 ! sternum +property_value: exactMatch http://identifiers.org/snomedct/92410006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347312 +property_value: exactMatch NCIT:C8416 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021457 +name: benign neoplasm of pleura +def: "A benign neoplasm that involves the pleura." [MONDO:patterns/location] +synonym: "benign neoplasm of the pleura" EXACT [NCIT:C3603] +synonym: "benign pleural neoplasm" EXACT [NCIT:C3603] +synonym: "benign pleural tumor" EXACT [NCIT:C3603] +synonym: "benign tumor of pleura" EXACT [NCIT:C3603] +synonym: "benign tumor of the pleura" EXACT [NCIT:C3603] +synonym: "pleura benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3603 {source="MONDO:equivalentTo"} +xref: SCTID:92298003 {source="MONDO:equivalentTo"} +xref: UMLS:C0153955 {source="MONDO:equivalentTo", source="NCIT:C3603"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0021065 {source="MONDO:Redundant", source="NCIT:C3603"} ! pleural neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000977 ! pleura +property_value: exactMatch http://identifiers.org/snomedct/92298003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153955 +property_value: exactMatch NCIT:C3603 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021458 +name: benign neoplasm of penis +def: "A benign neoplasm that involves the penis." [MONDO:patterns/location] +synonym: "benign neoplasm of the penis" EXACT [NCIT:C3489] +synonym: "benign penile neoplasm" EXACT [NCIT:C3489] +synonym: "benign penile tumor" EXACT [NCIT:C3489] +synonym: "benign tumor of penis" EXACT [NCIT:C3489] +synonym: "benign tumor of the penis" EXACT [NCIT:C3489] +synonym: "penis benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D29.0 {source="MONDO:equivalentTo"} +xref: ICD9:222.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3489 {source="MONDO:equivalentTo"} +xref: SCTID:92286008 {source="MONDO:equivalentTo"} +xref: UMLS:C0149627 {source="MONDO:equivalentTo", source="NCIT:C3489"} +is_a: MONDO:0000625 ! benign male reproductive system neoplasm +is_a: MONDO:0006895 {source="MONDO:Redundant", source="NCIT:C3489"} ! penile neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000989 ! penis +property_value: exactMatch http://identifiers.org/snomedct/92286008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0149627 +property_value: exactMatch https://icd.codes/icd10cm/D29.0 +property_value: exactMatch NCIT:C3489 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021459 +name: benign neoplasm of esophagus +def: "A benign neoplasm that involves the esophagus." [MONDO:patterns/location] +synonym: "benign esophageal neoplasm" EXACT [NCIT:C3598] +synonym: "benign esophageal tumor" EXACT [NCIT:C3598] +synonym: "benign esophagus neoplasm" EXACT [NCIT:C3598] +synonym: "benign esophagus tumor" EXACT [NCIT:C3598] +synonym: "benign neoplasm of the esophagus" EXACT [NCIT:C3598] +synonym: "benign tumor of esophagus" EXACT [NCIT:C3598] +synonym: "benign tumor of the esophagus" EXACT [NCIT:C3598] +synonym: "esophagus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D13.0 {source="MONDO:equivalentTo"} +xref: ICD9:211.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3598 {source="MONDO:equivalentTo"} +xref: SCTID:92091003 {source="MONDO:equivalentTo"} +xref: UMLS:C0153942 {source="MONDO:equivalentTo", source="NCIT:C3598"} +is_a: MONDO:0000385 {source="MONDO:Entailed", source="NCIT:C3598"} ! benign digestive system neoplasm +is_a: MONDO:0000634 ! thoracic benign neoplasm +is_a: MONDO:0021355 {source="MONDO:Redundant", source="NCIT:C3598"} ! neoplasm of esophagus +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001043 ! esophagus +property_value: exactMatch http://identifiers.org/snomedct/92091003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153942 +property_value: exactMatch https://icd.codes/icd10cm/D13.0 +property_value: exactMatch NCIT:C3598 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021460 +name: benign neoplasm of salivary gland +def: "A benign neoplasm that involves the saliva-secreting gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the salivary gland" EXACT [NCIT:C4600] +synonym: "benign salivary gland neoplasm" EXACT [NCIT:C4600] +synonym: "benign salivary gland tumor" EXACT [NCIT:C4600] +synonym: "benign tumor of salivary gland" EXACT [NCIT:C4600] +synonym: "benign tumor of the salivary gland" EXACT [NCIT:C4600] +synonym: "saliva-secreting gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "salivary gland neoplasm, benign" EXACT [NCIT:C4600] +xref: NCIT:C4600 {source="MONDO:equivalentTo"} +xref: SCTID:255154009 {source="MONDO:equivalentTo"} +xref: UMLS:C0347206 {source="MONDO:equivalentTo", source="NCIT:C4600"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0021357 {source="MONDO:Redundant", source="NCIT:C4600"} ! tumor of salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch http://identifiers.org/snomedct/255154009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347206 +property_value: exactMatch NCIT:C4600 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021461 +name: benign neoplasm of hypopharynx +def: "A benign neoplasm that involves the hypopharynx." [MONDO:patterns/location] +synonym: "benign hypopharyngeal neoplasm" EXACT [NCIT:C3596] +synonym: "benign hypopharyngeal tumor" EXACT [NCIT:C3596] +synonym: "benign neoplasm of the hypopharynx" EXACT [NCIT:C3596] +synonym: "benign tumor of hypopharynx" EXACT [NCIT:C3596] +synonym: "benign tumor of the hypopharynx" EXACT [NCIT:C3596] +synonym: "hypopharyngeal neoplasm, benign" EXACT [NCIT:C3596] +synonym: "hypopharynx benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D10.7 {source="MONDO:equivalentTo"} +xref: ICD9:210.8 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3596 {source="MONDO:equivalentTo"} +xref: SCTID:92139000 {source="MONDO:equivalentTo"} +xref: UMLS:C0153939 {source="MONDO:equivalentTo", source="NCIT:C3596"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0021358 {source="MONDO:Redundant", source="NCIT:C3596"} ! neoplasm of hypopharynx +is_a: MONDO:0021523 {source="MONDO:Redundant", source="NCIT:C3596"} ! benign neoplasm of pharynx +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001051 ! hypopharynx +property_value: exactMatch http://identifiers.org/snomedct/92139000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153939 +property_value: exactMatch https://icd.codes/icd10cm/D10.7 +property_value: exactMatch NCIT:C3596 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021462 +name: benign neoplasm of rectum +def: "A benign neoplasm that involves the rectum." [MONDO:patterns/location] +synonym: "benign neoplasm of the rectum" EXACT [NCIT:C4774] +synonym: "benign rectal neoplasm" EXACT [NCIT:C4774] +synonym: "benign rectal neoplasms" EXACT [NCIT:C4774] +synonym: "benign rectal tumor" EXACT [NCIT:C4774] +synonym: "benign rectal tumors" EXACT [NCIT:C4774] +synonym: "benign tumor of rectum" EXACT [NCIT:C4774] +synonym: "benign tumor of the rectum" EXACT [NCIT:C4774] +synonym: "rectal neoplasms, benign" EXACT [NCIT:C4774] +synonym: "rectal tumors, benign" EXACT [NCIT:C4774] +synonym: "rectum benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D12.8 {source="MONDO:equivalentTo"} +xref: NCIT:C4774 {source="MONDO:equivalentTo"} +xref: SCTID:92318000 {source="MONDO:equivalentTo"} +xref: UMLS:C0496867 {source="MONDO:equivalentTo", source="NCIT:C4774"} +is_a: MONDO:0002165 {source="MONDO:Redundant", source="NCIT:C4774"} ! rectal neoplasm +is_a: MONDO:0021444 {source="MONDO:Redundant", source="NCIT:C4774"} ! benign neoplasm of large intestine +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch http://identifiers.org/snomedct/92318000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496867 +property_value: exactMatch https://icd.codes/icd10cm/D12.8 +property_value: exactMatch NCIT:C4774 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021463 +name: benign neoplasm of parathyroid gland +def: "A benign neoplasm that involves the parathyroid gland." [MONDO:patterns/location] +synonym: "benign neoplasm of parathyroid" EXACT [NCIT:C3630] +synonym: "benign neoplasm of the parathyroid" EXACT [NCIT:C3630] +synonym: "benign neoplasm of the parathyroid gland" EXACT [NCIT:C3630] +synonym: "benign parathyroid gland neoplasm" EXACT [NCIT:C3630] +synonym: "benign parathyroid gland tumor" EXACT [NCIT:C3630] +synonym: "benign parathyroid neoplasm" EXACT [NCIT:C3630] +synonym: "benign parathyroid tumor" EXACT [NCIT:C3630] +synonym: "benign tumor of parathyroid" EXACT [NCIT:C3630] +synonym: "benign tumor of parathyroid gland" EXACT [NCIT:C3630] +synonym: "benign tumor of the parathyroid" EXACT [NCIT:C3630] +synonym: "benign tumor of the parathyroid gland" EXACT [NCIT:C3630] +synonym: "parathyroid gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "parathyroid tumor benign" EXACT [NCIT:C3630] +xref: DOID:60008 {source="MONDO:equivalentTo"} +xref: ICD10CM:D35.1 {source="MONDO:equivalentTo"} +xref: ICD9:227.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3630 {source="MONDO:equivalentTo"} +xref: SCTID:92272009 {source="MONDO:equivalentTo"} +xref: UMLS:C0154041 {source="MONDO:equivalentTo", source="NCIT:C3630"} +is_a: MONDO:0000627 {source="MONDO:Redundant"} ! benign endocrine neoplasm +is_a: MONDO:0021360 {source="MONDO:Redundant", source="NCIT:C3630"} ! tumor of parathyroid gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001132 ! parathyroid gland +property_value: exactMatch DOID:60008 +property_value: exactMatch http://identifiers.org/snomedct/92272009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154041 +property_value: exactMatch https://icd.codes/icd10cm/D35.1 +property_value: exactMatch NCIT:C3630 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021464 +name: benign neoplasm of cecum +def: "A benign neoplasm that involves the caecum." [MONDO:patterns/location] +synonym: "benign cecum neoplasm" EXACT [NCIT:C4772] +synonym: "benign cecum tumor" EXACT [NCIT:C4772] +synonym: "benign neoplasm of the cecum" EXACT [NCIT:C4772] +synonym: "benign tumor of cecum" EXACT [NCIT:C4772] +synonym: "benign tumor of the cecum" EXACT [NCIT:C4772] +synonym: "caecum benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D12.0 {source="MONDO:equivalentTo"} +xref: NCIT:C4772 {source="MONDO:equivalentTo"} +xref: SCTID:92040001 {source="MONDO:equivalentTo"} +xref: UMLS:C0496859 {source="MONDO:equivalentTo", source="NCIT:C4772"} +is_a: MONDO:0002278 {source="MONDO:Redundant", source="NCIT:C4772"} ! benign colon neoplasm +is_a: MONDO:0005694 {source="MONDO:Redundant", source="NCIT:C4772"} ! cecal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001153 ! caecum +property_value: exactMatch http://identifiers.org/snomedct/92040001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496859 +property_value: exactMatch https://icd.codes/icd10cm/D12.0 +property_value: exactMatch NCIT:C4772 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021465 +name: benign neoplasm of appendix +def: "A benign neoplasm that involves the vermiform appendix." [MONDO:patterns/location] +synonym: "benign appendix neoplasm" EXACT [NCIT:C4773] +synonym: "benign appendix tumor" EXACT [NCIT:C4773] +synonym: "benign neoplasm of the appendix" EXACT [NCIT:C4773] +synonym: "benign tumor of appendix" EXACT [NCIT:C4773] +synonym: "benign tumor of the appendix" EXACT [NCIT:C4773] +synonym: "vermiform appendix benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D12.1 {source="MONDO:equivalentTo"} +xref: NCIT:C4773 {source="MONDO:equivalentTo"} +xref: SCTID:91981009 {source="MONDO:equivalentTo"} +xref: UMLS:C0496860 {source="MONDO:equivalentTo", source="NCIT:C4773"} +is_a: MONDO:0001236 {source="MONDO:Redundant", source="NCIT:C4773"} ! appendiceal neoplasm +is_a: MONDO:0021464 ! benign neoplasm of cecum +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch http://identifiers.org/snomedct/91981009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496860 +property_value: exactMatch https://icd.codes/icd10cm/D12.1 +property_value: exactMatch NCIT:C4773 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021467 +name: benign neoplasm of renal pelvis +def: "A benign neoplasm that involves the renal pelvis." [MONDO:patterns/location] +synonym: "benign kidney pelvis neoplasm" EXACT [NCIT:C3616] +synonym: "benign neoplasm of the renal pelvis" EXACT [NCIT:C3616] +synonym: "benign renal pelvis neoplasm" EXACT [NCIT:C3616] +synonym: "benign renal pelvis tumor" EXACT [NCIT:C3616] +synonym: "benign tumor of renal pelvis" EXACT [NCIT:C3616] +synonym: "benign tumor of the renal pelvis" EXACT [NCIT:C3616] +synonym: "renal pelvis benign neoplasm" EXACT [MONDO:patterns/location] +xref: EFO:1000118 {source="MONDO:equivalentTo"} +xref: ICD9:223.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3616 {source="MONDO:equivalentTo"} +xref: SCTID:92319008 {source="MONDO:equivalentTo"} +xref: UMLS:C0154015 {source="NCIT:C3616", source="MONDO:equivalentTo"} +is_a: MONDO:0002513 {source="MONDO:Redundant", source="NCIT:C3616"} ! kidney benign neoplasm +is_a: MONDO:0003719 {source="MONDO:Redundant", source="NCIT:C3616"} ! renal pelvis neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch http://identifiers.org/snomedct/92319008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154015 +property_value: exactMatch NCIT:C3616 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021468 +name: benign neoplasm of adrenal medulla +def: "A benign neoplasm that involves the adrenal medulla." [MONDO:patterns/location] +synonym: "adrenal medulla benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "benign adrenal medulla neoplasm" EXACT [NCIT:C4895] +synonym: "benign adrenal medulla tumor" EXACT [NCIT:C4895] +synonym: "benign neoplasm of the adrenal medulla" EXACT [NCIT:C4895] +synonym: "benign tumor of adrenal medulla" EXACT [NCIT:C4895] +synonym: "benign tumor of the adrenal medulla" EXACT [NCIT:C4895] +xref: NCIT:C4895 {source="MONDO:equivalentTo"} +xref: SCTID:91968002 {source="MONDO:equivalentTo"} +xref: UMLS:C0686512 {source="MONDO:equivalentTo", source="NCIT:C4895"} +is_a: MONDO:0021237 {source="MONDO:Redundant", source="NCIT:C4895"} ! adrenal medulla neoplasm +is_a: MONDO:0021511 {source="MONDO:Redundant", source="NCIT:C4895"} ! benign neoplasm of adrenal gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001236 ! adrenal medulla +property_value: exactMatch http://identifiers.org/snomedct/91968002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686512 +property_value: exactMatch NCIT:C4895 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021469 +name: benign neoplasm of anus +def: "A benign neoplasm that involves the anus." [MONDO:patterns/location] +synonym: "anus benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "benign anal neoplasm" EXACT [NCIT:C4611] +synonym: "benign anal tumor" EXACT [NCIT:C4611] +synonym: "benign neoplasm of the anus" EXACT [NCIT:C4611] +synonym: "benign tumor of anus" EXACT [NCIT:C4611] +synonym: "benign tumor of the anus" EXACT [NCIT:C4611] +xref: NCIT:C4611 {source="MONDO:equivalentTo"} +xref: SCTID:91978004 {source="MONDO:equivalentTo"} +xref: UMLS:C0347276 {source="MONDO:equivalentTo", source="NCIT:C4611"} +is_a: MONDO:0003046 {source="MONDO:Redundant", source="NCIT:C4611"} ! anus neoplasm +is_a: MONDO:0021462 ! benign neoplasm of rectum +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001245 ! anus +property_value: exactMatch http://identifiers.org/snomedct/91978004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347276 +property_value: exactMatch NCIT:C4611 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021470 +name: benign neoplasm of pancreas +def: "A benign neoplasm that involves the pancreas." [MONDO:patterns/location] +synonym: "benign neoplasm of the pancreas" EXACT [NCIT:C4612] +synonym: "benign pancreas neoplasm" EXACT [NCIT:C4612] +synonym: "benign pancreas tumor" EXACT [NCIT:C4612] +synonym: "benign pancreatic neoplasm" EXACT [NCIT:C4612] +synonym: "benign pancreatic tumor" EXACT [NCIT:C4612] +synonym: "benign tumor of pancreas" EXACT [NCIT:C4612] +synonym: "benign tumor of the pancreas" EXACT [NCIT:C4612] +synonym: "pancreas benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "pancreas neoplasm, benign" EXACT [NCIT:C4612] +synonym: "pancreas tumor, benign" EXACT [NCIT:C4612] +synonym: "pancreatic neoplasm, benign" EXACT [NCIT:C4612] +synonym: "pancreatic tumor, benign" EXACT [NCIT:C4612] +xref: ICD10CM:D13.6 {source="MONDO:equivalentTo"} +xref: NCIT:C4612 {source="MONDO:equivalentTo"} +xref: SCTID:92264007 {source="MONDO:equivalentTo"} +xref: UMLS:C0347284 {source="MONDO:equivalentTo", source="NCIT:C4612"} +is_a: MONDO:0000385 ! benign digestive system neoplasm +is_a: MONDO:0021040 {source="MONDO:Redundant", source="NCIT:C4612"} ! pancreatic neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001264 ! pancreas +property_value: exactMatch http://identifiers.org/snomedct/92264007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347284 +property_value: exactMatch https://icd.codes/icd10cm/D13.6 +property_value: exactMatch NCIT:C4612 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021471 +name: benign neoplasm of endometrium +def: "A benign neoplasm that involves the endometrium." [MONDO:patterns/location] +synonym: "benign endometrial neoplasm" EXACT [NCIT:C4894] +synonym: "benign endometrial tumor" EXACT [NCIT:C4894] +synonym: "benign endometrium neoplasm" EXACT [NCIT:C4894] +synonym: "benign endometrium tumor" EXACT [NCIT:C4894] +synonym: "benign neoplasm of the endometrium" EXACT [NCIT:C4894] +synonym: "benign tumor of endometrium" EXACT [NCIT:C4894] +synonym: "benign tumor of the endometrium" EXACT [NCIT:C4894] +synonym: "endometrium benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4894 {source="MONDO:equivalentTo"} +xref: SCTID:92086004 {source="MONDO:equivalentTo"} +xref: UMLS:C0686239 {source="MONDO:equivalentTo", source="NCIT:C4894"} +is_a: MONDO:0000632 {source="MONDO:Redundant", source="NCIT:C4894/inferred"} ! uterine benign neoplasm +is_a: MONDO:0021251 {source="MONDO:Redundant", source="NCIT:C4894"} ! endometrium neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001295 ! endometrium +property_value: exactMatch http://identifiers.org/snomedct/92086004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686239 +property_value: exactMatch NCIT:C4894 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021472 +name: benign neoplasm of scrotum +def: "A benign neoplasm that involves the scrotum." [MONDO:patterns/location] +synonym: "benign neoplasm of the scrotum" EXACT [NCIT:C3615] +synonym: "benign scrotal neoplasm" EXACT [NCIT:C3615] +synonym: "benign scrotal tumor" EXACT [NCIT:C3615] +synonym: "benign tumor of scrotum" EXACT [NCIT:C3615] +synonym: "benign tumor of the scrotum" EXACT [NCIT:C3615] +synonym: "scrotum benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D29.4 {source="MONDO:equivalentTo"} +xref: ICD9:222.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3615 {source="MONDO:equivalentTo"} +xref: SCTID:92336000 {source="MONDO:equivalentTo"} +xref: UMLS:C0154011 {source="MONDO:equivalentTo", source="NCIT:C3615"} +is_a: MONDO:0000625 ! benign male reproductive system neoplasm +is_a: MONDO:0003319 {source="MONDO:Redundant", source="NCIT:C3615"} ! scrotum neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch http://identifiers.org/snomedct/92336000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154011 +property_value: exactMatch https://icd.codes/icd10cm/D29.4 +property_value: exactMatch NCIT:C3615 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021473 +name: benign neoplasm of epididymis +def: "A benign neoplasm that involves the epididymis." [MONDO:patterns/location] +synonym: "benign epididymal neoplasm" EXACT [NCIT:C3614] +synonym: "benign epididymal tumor" EXACT [NCIT:C3614] +synonym: "benign neoplasm of the epididymis" EXACT [NCIT:C3614] +synonym: "benign tumor of epididymis" EXACT [NCIT:C3614] +synonym: "benign tumor of the epididymis" EXACT [NCIT:C3614] +synonym: "epididymis benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:222.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3614 {source="MONDO:equivalentTo"} +xref: SCTID:92088003 {source="MONDO:equivalentTo"} +xref: UMLS:C0154010 {source="MONDO:equivalentTo", source="NCIT:C3614"} +is_a: MONDO:0000625 ! benign male reproductive system neoplasm +is_a: MONDO:0003283 {source="MONDO:Redundant", source="NCIT:C3614"} ! epididymal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001301 ! epididymis +property_value: exactMatch http://identifiers.org/snomedct/92088003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154010 +property_value: exactMatch NCIT:C3614 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021474 +name: benign neoplasm of ear +def: "A benign neoplasm that involves the ear." [MONDO:patterns/location] +synonym: "aural neoplasms, benign" EXACT [NCIT:C8417] +synonym: "benign Ear neoplasm" EXACT [NCIT:C8417] +synonym: "benign Ear tumor" EXACT [NCIT:C8417] +synonym: "benign neoplasm of the Ear" EXACT [NCIT:C8417] +synonym: "benign tumor of Ear" EXACT [NCIT:C8417] +synonym: "benign tumor of the Ear" EXACT [NCIT:C8417] +synonym: "ear benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8417 {source="MONDO:equivalentTo"} +xref: SCTID:255181009 {source="MONDO:equivalentTo"} +xref: UMLS:C0347354 {source="MONDO:equivalentTo", source="NCIT:C8417"} +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0021233 {source="MONDO:Redundant", source="NCIT:C8417"} ! ear neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001690 ! ear +property_value: exactMatch http://identifiers.org/snomedct/255181009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347354 +property_value: exactMatch NCIT:C8417 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021475 +name: benign neoplasm of nasal cavity +def: "A benign neoplasm that involves the nasal cavity." [MONDO:patterns/location] +synonym: "benign nasal cavity neoplasm" EXACT [NCIT:C4603] +synonym: "benign nasal cavity tumor" EXACT [NCIT:C4603] +synonym: "benign neoplasm of the nasal cavity" EXACT [NCIT:C4603] +synonym: "benign tumor of nasal cavity" EXACT [NCIT:C4603] +synonym: "benign tumor of the nasal cavity" EXACT [NCIT:C4603] +synonym: "nasal cavity benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4603 {source="MONDO:equivalentTo"} +xref: SCTID:92241005 {source="MONDO:equivalentTo"} +xref: UMLS:C0347215 {source="MONDO:equivalentTo", source="NCIT:C4603"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0004756 {source="MONDO:Redundant", source="NCIT:C4603"} ! nasal cavity neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001707 ! nasal cavity +property_value: exactMatch http://identifiers.org/snomedct/92241005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347215 +property_value: exactMatch NCIT:C4603 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021476 +name: benign neoplasm of tongue +def: "A benign neoplasm that involves the tongue." [MONDO:patterns/location] +synonym: "benign neoplasm of the tongue" EXACT [NCIT:C3592] +synonym: "benign tongue neoplasm" EXACT [NCIT:C3592] +synonym: "benign tongue tumor" EXACT [NCIT:C3592] +synonym: "benign tumor of the tongue" EXACT [NCIT:C3592] +synonym: "benign tumor of tongue" EXACT [NCIT:C3592] +synonym: "tongue benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "tongue neoplasm, benign" EXACT [NCIT:C3592] +xref: ICD10CM:D10.1 {source="MONDO:equivalentTo"} +xref: ICD9:210.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3592 {source="MONDO:equivalentTo"} +xref: SCTID:92443005 {source="MONDO:equivalentTo"} +xref: UMLS:C0153933 {source="NCIT:C3592", source="MONDO:equivalentTo"} +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0021240 {source="MONDO:Redundant", source="NCIT:C3592"} ! tongue neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001723 ! tongue +property_value: exactMatch http://identifiers.org/snomedct/92443005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153933 +property_value: exactMatch https://icd.codes/icd10cm/D10.1 +property_value: exactMatch NCIT:C3592 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021477 +name: benign neoplasm of sphenoidal sinus +def: "A non-metastasizing neoplasm that arises from the sphenoid sinus." [NCIT:C4422] +synonym: "benign neoplasm of sphenoid sinus" EXACT [NCIT:C4422] +synonym: "benign neoplasm of the sphenoid sinus" EXACT [NCIT:C4422] +synonym: "benign neoplasm of the sphenoidal sinus" EXACT [NCIT:C4422] +synonym: "benign sphenoid sinus neoplasm" EXACT [NCIT:C4422] +synonym: "benign sphenoid sinus tumor" EXACT [NCIT:C4422] +synonym: "benign sphenoidal sinus neoplasm" EXACT [NCIT:C4422] +synonym: "benign sphenoidal sinus tumor" EXACT [NCIT:C4422] +synonym: "benign tumor of sphenoid sinus" EXACT [NCIT:C4422] +synonym: "benign tumor of sphenoidal sinus" EXACT [NCIT:C4422] +synonym: "benign tumor of the sphenoid sinus" EXACT [NCIT:C4422] +synonym: "benign tumor of the sphenoidal sinus" EXACT [NCIT:C4422] +synonym: "sphenoidal sinus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4422 {source="MONDO:equivalentTo"} +xref: SCTID:92404006 {source="MONDO:equivalentTo"} +xref: UMLS:C0345678 {source="MONDO:equivalentTo", source="NCIT:C4422"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0004047 {source="MONDO:Redundant", source="NCIT:C4422"} ! sphenoidal sinus neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001724 ! sphenoidal sinus +property_value: exactMatch http://identifiers.org/snomedct/92404006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345678 +property_value: exactMatch NCIT:C4422 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021478 +name: benign neoplasm of nasopharynx +def: "A benign neoplasm that involves the nasopharynx." [MONDO:patterns/location] +synonym: "benign nasopharyngeal neoplasm" EXACT [NCIT:C3595] +synonym: "benign nasopharyngeal tumor" EXACT [NCIT:C3595] +synonym: "benign neoplasm of the nasopharynx" EXACT [NCIT:C3595] +synonym: "benign tumor of nasopharynx" EXACT [NCIT:C3595] +synonym: "benign tumor of the nasopharynx" EXACT [NCIT:C3595] +synonym: "nasopharyngeal neoplasm, benign" EXACT [NCIT:C3595] +synonym: "nasopharynx benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D10.6 {source="MONDO:equivalentTo"} +xref: ICD9:210.7 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3595 {source="MONDO:equivalentTo"} +xref: SCTID:188800003 {source="MONDO:equivalentTo"} +xref: UMLS:C0153938 {source="MONDO:equivalentTo", source="NCIT:C3595"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0005375 {source="MONDO:Redundant", source="NCIT:C3595"} ! nasopharyngeal neoplasm +is_a: MONDO:0021523 {source="MONDO:Redundant", source="NCIT:C3595"} ! benign neoplasm of pharynx +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001728 ! nasopharynx +property_value: exactMatch http://identifiers.org/snomedct/188800003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153938 +property_value: exactMatch https://icd.codes/icd10cm/D10.6 +property_value: exactMatch NCIT:C3595 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021479 +name: benign neoplasm of oropharynx +def: "A benign neoplasm that involves the oropharynx." [MONDO:patterns/location] +synonym: "benign neoplasm of the oropharynx" EXACT [NCIT:C4604] +synonym: "benign oropharyngeal neoplasm" EXACT [NCIT:C4604] +synonym: "benign oropharyngeal tumor" EXACT [NCIT:C4604] +synonym: "benign tumor of oropharynx" EXACT [NCIT:C4604] +synonym: "benign tumor of the oropharynx" EXACT [NCIT:C4604] +synonym: "oropharyngeal neoplasm benign" EXACT [NCIT:C4604] +synonym: "oropharynx benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.6 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4604 {source="MONDO:equivalentTo"} +xref: SCTID:92259008 {source="MONDO:equivalentTo"} +xref: UMLS:C0347229 {source="MONDO:equivalentTo"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000385 ! benign digestive system neoplasm +is_a: MONDO:0021364 {source="MONDO:Redundant", source="NCIT:C4604"} ! neoplasm of oropharynx +is_a: MONDO:0021523 {source="MONDO:Redundant", source="NCIT:C4604"} ! benign neoplasm of pharynx +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001729 ! oropharynx +property_value: exactMatch http://identifiers.org/snomedct/92259008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347229 +property_value: exactMatch NCIT:C4604 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021480 +name: benign neoplasm of soft palate +def: "A benign neoplasm that involves the soft palate." [MONDO:patterns/location] +synonym: "benign neoplasm of the soft palate" EXACT [NCIT:C4404] +synonym: "benign soft palate neoplasm" EXACT [NCIT:C4404] +synonym: "benign soft palate tumor" EXACT [NCIT:C4404] +synonym: "benign tumor of soft palate" EXACT [NCIT:C4404] +synonym: "benign tumor of the soft palate" EXACT [NCIT:C4404] +synonym: "soft palate benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4404 {source="MONDO:equivalentTo"} +xref: SCTID:92386006 {source="MONDO:equivalentTo"} +xref: UMLS:C0345557 {source="MONDO:equivalentTo", source="NCIT:C4404"} +is_a: MONDO:0005286 ! palatal neoplasm +is_a: MONDO:0021445 ! benign neoplasm of oral cavity +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001733 ! soft palate +relationship: disease_has_location UBERON:0001733 ! soft palate +property_value: exactMatch http://identifiers.org/snomedct/92386006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345557 +property_value: exactMatch NCIT:C4404 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021481 +name: benign neoplasm of submandibular gland +def: "A benign neoplasm that involves the submandibular gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the submandibular gland" EXACT [NCIT:C4891] +synonym: "benign submandibular gland neoplasm" EXACT [NCIT:C4891] +synonym: "benign submandibular gland tumor" EXACT [NCIT:C4891] +synonym: "benign tumor of submandibular gland" EXACT [NCIT:C4891] +synonym: "benign tumor of the submandibular gland" EXACT [NCIT:C4891] +synonym: "submandibular gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4891 {source="MONDO:equivalentTo"} +xref: SCTID:92415001 {source="MONDO:equivalentTo"} +xref: UMLS:C0685988 {source="NCIT:C4891", source="MONDO:equivalentTo"} +is_a: MONDO:0021244 {source="MONDO:Redundant", source="NCIT:C4891"} ! submandibular gland neoplasm +is_a: MONDO:0021492 {source="MONDO:Redundant", source="NCIT:C4891"} ! benign neoplasm of major salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001736 ! submandibular gland +property_value: exactMatch http://identifiers.org/snomedct/92415001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0685988 +property_value: exactMatch NCIT:C4891 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021482 +name: benign neoplasm of middle ear +def: "A benign neoplasm that involves the middle ear." [MONDO:patterns/location] +synonym: "benign middle Ear neoplasm" EXACT [NCIT:C4602] +synonym: "benign middle Ear tumor" EXACT [NCIT:C4602] +synonym: "benign neoplasm of the middle Ear" EXACT [NCIT:C4602] +synonym: "benign tumor of middle Ear" EXACT [NCIT:C4602] +synonym: "benign tumor of the middle Ear" EXACT [NCIT:C4602] +synonym: "middle ear benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4602 {source="MONDO:equivalentTo"} +xref: SCTID:92218002 {source="MONDO:equivalentTo"} +xref: UMLS:C0347213 {source="MONDO:equivalentTo", source="NCIT:C4602"} +is_a: MONDO:0021366 {source="MONDO:Redundant", source="NCIT:C4602"} ! neoplasm of middle ear +is_a: MONDO:0021474 {source="MONDO:Redundant", source="NCIT:C4602"} ! benign neoplasm of ear +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001756 ! middle ear +property_value: exactMatch http://identifiers.org/snomedct/92218002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347213 +property_value: exactMatch NCIT:C4602 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021483 +name: benign neoplasm of frontal sinus +def: "A benign neoplasm that involves the frontal sinus." [MONDO:patterns/location] +synonym: "benign frontal sinus neoplasm" EXACT [NCIT:C4420] +synonym: "benign frontal sinus tumor" EXACT [NCIT:C4420] +synonym: "benign neoplasm of the frontal sinus" EXACT [NCIT:C4420] +synonym: "benign tumor of frontal sinus" EXACT [NCIT:C4420] +synonym: "benign tumor of the frontal sinus" EXACT [NCIT:C4420] +synonym: "frontal sinus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4420 {source="MONDO:equivalentTo"} +xref: SCTID:92115005 {source="MONDO:equivalentTo"} +xref: UMLS:C0345674 {source="MONDO:equivalentTo", source="NCIT:C4420"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0001757 {source="MONDO:Redundant", source="NCIT:C4420"} ! frontal sinus neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001760 ! frontal sinus +property_value: exactMatch http://identifiers.org/snomedct/92115005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345674 +property_value: exactMatch NCIT:C4420 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021484 +name: benign neoplasm of maxillary sinus +def: "A benign neoplasm that involves the maxillary sinus." [MONDO:patterns/location] +synonym: "benign maxillary antrum neoplasm" EXACT [NCIT:C4414] +synonym: "benign maxillary antrum tumor" EXACT [NCIT:C4414] +synonym: "benign maxillary sinus neoplasm" EXACT [NCIT:C4414] +synonym: "benign maxillary sinus tumor" EXACT [NCIT:C4414] +synonym: "benign maxillofacial sinus neoplasm" EXACT [NCIT:C4414] +synonym: "benign maxillofacial sinus tumor" EXACT [NCIT:C4414] +synonym: "benign neoplasm of maxillary antrum" EXACT [NCIT:C4414] +synonym: "benign neoplasm of maxillofacial sinus" EXACT [NCIT:C4414] +synonym: "benign neoplasm of the maxillary antrum" EXACT [NCIT:C4414] +synonym: "benign neoplasm of the maxillary sinus" EXACT [NCIT:C4414] +synonym: "benign neoplasm of the maxillofacial sinus" EXACT [NCIT:C4414] +synonym: "benign tumor of maxillary antrum" EXACT [NCIT:C4414] +synonym: "benign tumor of maxillary sinus" EXACT [NCIT:C4414] +synonym: "benign tumor of maxillofacial sinus" EXACT [NCIT:C4414] +synonym: "benign tumor of the maxillary antrum" EXACT [NCIT:C4414] +synonym: "benign tumor of the maxillary sinus" EXACT [NCIT:C4414] +synonym: "benign tumor of the maxillofacial sinus" EXACT [NCIT:C4414] +synonym: "maxillary sinus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4414 {source="MONDO:equivalentTo"} +xref: SCTID:92211008 {source="MONDO:equivalentTo"} +xref: UMLS:C0345666 {source="MONDO:equivalentTo", source="NCIT:C4414"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0006850 {source="MONDO:Redundant", source="NCIT:C4414"} ! maxillary sinus neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001764 ! maxillary sinus +property_value: exactMatch http://identifiers.org/snomedct/92211008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345666 +property_value: exactMatch NCIT:C4414 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021485 +name: benign neoplasm of iris +def: "A benign neoplasm that involves the iris." [MONDO:patterns/location] +synonym: "benign iris neoplasm" EXACT [NCIT:C4555] +synonym: "benign iris tumor" EXACT [NCIT:C4555] +synonym: "benign neoplasm of the iris" EXACT [NCIT:C4555] +synonym: "benign tumor of iris" EXACT [NCIT:C4555] +synonym: "benign tumor of the iris" EXACT [NCIT:C4555] +synonym: "iris benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4555 {source="MONDO:equivalentTo"} +xref: SCTID:189151003 {source="MONDO:equivalentTo"} +xref: UMLS:C0346374 {source="MONDO:equivalentTo", source="NCIT:C4555"} +is_a: MONDO:0021224 {source="MONDO:Redundant", source="NCIT:C4555"} ! iris neoplasm +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C4555/inferred"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001769 ! iris +property_value: exactMatch http://identifiers.org/snomedct/189151003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346374 +property_value: exactMatch NCIT:C4555 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021486 +name: benign neoplasm of ciliary body +def: "A benign neoplasm that involves the ciliary body." [MONDO:patterns/location] +synonym: "benign ciliary body neoplasm" EXACT [NCIT:C4779] +synonym: "benign ciliary body tumor" EXACT [NCIT:C4779] +synonym: "benign neoplasm of the ciliary body" EXACT [NCIT:C4779] +synonym: "benign tumor of ciliary body" EXACT [NCIT:C4779] +synonym: "benign tumor of the ciliary body" EXACT [NCIT:C4779] +synonym: "ciliary body benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4779 {source="MONDO:equivalentTo"} +xref: SCTID:92060009 {source="MONDO:equivalentTo"} +xref: UMLS:C0496894 {source="MONDO:equivalentTo", source="NCIT:C4779"} +is_a: MONDO:0021229 {source="MONDO:Redundant", source="NCIT:C4779"} ! ciliary body neoplasm +is_a: MONDO:0021485 ! benign neoplasm of iris +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001775 ! ciliary body +property_value: exactMatch http://identifiers.org/snomedct/92060009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496894 +property_value: exactMatch NCIT:C4779 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021487 +name: benign neoplasm of choroid +def: "A benign neoplasm that involves the optic choroid." [MONDO:patterns/location] +synonym: "benign choroid neoplasm" EXACT [NCIT:C3625] +synonym: "benign choroid tumor" EXACT [NCIT:C3625] +synonym: "benign neoplasm of the choroid" EXACT [NCIT:C3625] +synonym: "benign tumor of choroid" EXACT [NCIT:C3625] +synonym: "benign tumor of the choroid" EXACT [NCIT:C3625] +synonym: "optic choroid benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.6 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3625 {source="MONDO:equivalentTo"} +xref: SCTID:92059004 {source="MONDO:equivalentTo"} +xref: UMLS:C0154028 {source="MONDO:equivalentTo", source="NCIT:C3625"} +is_a: MONDO:0000629 ! cardiovascular organ benign neoplasm +is_a: MONDO:0021258 {source="MONDO:Redundant", source="NCIT:C3625"} ! choroid neoplasm +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C3625/inferred"} ! benign neoplasm of eye +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001776 ! optic choroid +property_value: exactMatch http://identifiers.org/snomedct/92059004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154028 +property_value: exactMatch NCIT:C3625 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021488 +name: benign neoplasm of lacrimal gland +def: "A benign neoplasm that involves the lacrimal gland." [MONDO:patterns/location] +synonym: "benign lacrimal gland neoplasm" EXACT [NCIT:C3621] +synonym: "benign lacrimal gland tumor" EXACT [NCIT:C3621] +synonym: "benign neoplasm of the lacrimal gland" EXACT [NCIT:C3621] +synonym: "benign tumor of lacrimal gland" EXACT [NCIT:C3621] +synonym: "benign tumor of the lacrimal gland" EXACT [NCIT:C3621] +synonym: "lacrimal gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:224.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3621 {source="MONDO:equivalentTo"} +xref: SCTID:92169007 {source="MONDO:equivalentTo"} +xref: UMLS:C0154024 {source="MONDO:equivalentTo", source="NCIT:C3621"} +is_a: MONDO:0021222 {source="MONDO:Redundant", source="NCIT:C3621"} ! lacrimal gland neoplasm +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C3621"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch http://identifiers.org/snomedct/92169007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154024 +property_value: exactMatch NCIT:C3621 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021489 +name: benign neoplasm of sweat gland +def: "A benign neoplasm that involves the sweat gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the sweat gland" EXACT [NCIT:C4879] +synonym: "benign sweat gland neoplasm" EXACT [NCIT:C4879] +synonym: "benign sweat gland tumor" EXACT [NCIT:C4879] +synonym: "benign tumor of sweat gland" EXACT [NCIT:C4879] +synonym: "benign tumor of the sweat gland" EXACT [NCIT:C4879] +synonym: "sweat gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "sweat gland neoplasm, benign" EXACT [NCIT:C4879] +xref: NCIT:C4879 {source="MONDO:equivalentTo"} +xref: SCTID:92422009 {source="MONDO:equivalentTo"} +xref: UMLS:C0684354 {source="MONDO:equivalentTo", source="NCIT:C4879"} +is_a: MONDO:0002381 {source="MONDO:Redundant", source="NCIT:C4879"} ! sweat gland neoplasm +is_a: MONDO:0021440 {source="MONDO:Redundant", source="NCIT:C4879/inferred"} ! benign neoplasm of skin +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001820 ! sweat gland +property_value: exactMatch http://identifiers.org/snomedct/92422009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684354 +property_value: exactMatch NCIT:C4879 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021490 +name: benign neoplasm of sebaceous gland +def: "A benign neoplasm that involves the sebaceous gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the sebaceous gland" EXACT [NCIT:C8525] +synonym: "benign sebaceous gland neoplasm" EXACT [NCIT:C8525] +synonym: "benign sebaceous gland tumor" EXACT [NCIT:C8525] +synonym: "benign sebaceous neoplasm" EXACT [NCIT:C8525] +synonym: "benign sebaceous skin neoplasm" EXACT [NCIT:C8525] +synonym: "benign sebaceous skin tumor" EXACT [NCIT:C8525] +synonym: "benign sebaceous tumor" EXACT [NCIT:C8525] +synonym: "benign tumor of sebaceous gland" EXACT [NCIT:C8525] +synonym: "benign tumor of the sebaceous gland" EXACT [NCIT:C8525] +synonym: "sebaceous gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8525 {source="MONDO:equivalentTo"} +xref: SCTID:92337009 {source="MONDO:equivalentTo"} +xref: UMLS:C0684358 {source="MONDO:equivalentTo", source="NCIT:C8525"} +is_a: MONDO:0006963 {source="MONDO:Redundant", source="NCIT:C8525"} ! sebaceous gland neoplasm +is_a: MONDO:0021440 {source="MONDO:Redundant", source="NCIT:C8525/inferred"} ! benign neoplasm of skin +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001821 ! sebaceous gland +property_value: exactMatch http://identifiers.org/snomedct/92337009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684358 +property_value: exactMatch NCIT:C8525 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021491 +name: benign neoplasm of gum +def: "A benign neoplasm that involves the gingiva." [MONDO:patterns/location] +synonym: "benign gingival neoplasm" EXACT [NCIT:C4598] +synonym: "benign gingival tumor" EXACT [NCIT:C4598] +synonym: "benign gum neoplasm" EXACT [NCIT:C4598] +synonym: "benign gum tumor" EXACT [NCIT:C4598] +synonym: "benign neoplasm of gingiva" EXACT [NCIT:C4598] +synonym: "benign neoplasm of the gingiva" EXACT [NCIT:C4598] +synonym: "benign neoplasm of the gum" EXACT [NCIT:C4598] +synonym: "benign tumor of gingiva" EXACT [NCIT:C4598] +synonym: "benign tumor of gum" EXACT [NCIT:C4598] +synonym: "benign tumor of the gingiva" EXACT [NCIT:C4598] +synonym: "benign tumor of the gum" EXACT [NCIT:C4598] +synonym: "gingiva benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4598 {source="MONDO:equivalentTo"} +xref: SCTID:92126004 {source="MONDO:equivalentTo"} +xref: UMLS:C0347201 {source="MONDO:equivalentTo", source="NCIT:C4598"} +is_a: MONDO:0000636 ! musculoskeletal system benign neoplasm +is_a: MONDO:0021086 {source="MONDO:Redundant", source="NCIT:C4598"} ! gingival neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001828 ! gingiva +property_value: exactMatch http://identifiers.org/snomedct/92126004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347201 +property_value: exactMatch NCIT:C4598 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021492 +name: benign neoplasm of major salivary gland +def: "A benign neoplasm that involves the major salivary gland." [MONDO:patterns/location] +synonym: "benign Major salivary gland neoplasm" EXACT [NCIT:C4771] +synonym: "benign Major salivary gland tumor" EXACT [NCIT:C4771] +synonym: "benign neoplasm of the Major salivary gland" EXACT [NCIT:C4771] +synonym: "benign tumor of Major salivary gland" EXACT [NCIT:C4771] +synonym: "benign tumor of the Major salivary gland" EXACT [NCIT:C4771] +synonym: "major salivary gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4771 {source="MONDO:equivalentTo"} +xref: SCTID:92205005 {source="MONDO:equivalentTo"} +xref: UMLS:C0496858 {source="NCIT:C4771", source="MONDO:equivalentTo"} +is_a: MONDO:0021368 {source="MONDO:Redundant", source="NCIT:C4771"} ! neoplasm of major salivary gland +is_a: MONDO:0021460 {source="MONDO:Redundant", source="NCIT:C4771"} ! benign neoplasm of salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001829 ! major salivary gland +property_value: exactMatch http://identifiers.org/snomedct/92205005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496858 +property_value: exactMatch NCIT:C4771 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021493 +name: benign neoplasm of minor salivary gland +def: "A benign neoplasm that involves the minor salivary gland." [MONDO:patterns/location] +synonym: "benign minor salivary gland neoplasm" EXACT [NCIT:C4411] +synonym: "benign minor salivary gland tumor" EXACT [NCIT:C4411] +synonym: "benign neoplasm of the minor salivary gland" EXACT [NCIT:C4411] +synonym: "benign tumor of minor salivary gland" EXACT [NCIT:C4411] +synonym: "benign tumor of the minor salivary gland" EXACT [NCIT:C4411] +synonym: "minor salivary gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4411 {source="MONDO:equivalentTo"} +xref: SCTID:92220004 {source="MONDO:equivalentTo"} +xref: UMLS:C0345615 {source="MONDO:equivalentTo", source="NCIT:C4411"} +is_a: MONDO:0021370 {source="MONDO:Redundant", source="NCIT:C4411"} ! neoplasm of minor salivary gland +is_a: MONDO:0021460 {source="MONDO:Redundant", source="NCIT:C4411"} ! benign neoplasm of salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001830 ! minor salivary gland +property_value: exactMatch http://identifiers.org/snomedct/92220004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345615 +property_value: exactMatch NCIT:C4411 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021494 +name: benign neoplasm of parotid gland +def: "A benign neoplasm that involves the parotid gland." [MONDO:patterns/location] +synonym: "benign neoplasm of parotid" EXACT [NCIT:C4770] +synonym: "benign neoplasm of the parotid" EXACT [NCIT:C4770] +synonym: "benign neoplasm of the parotid gland" EXACT [NCIT:C4770] +synonym: "benign parotid gland neoplasm" EXACT [NCIT:C4770] +synonym: "benign parotid gland tumor" EXACT [NCIT:C4770] +synonym: "benign parotid neoplasm" EXACT [NCIT:C4770] +synonym: "benign parotid tumor" EXACT [NCIT:C4770] +synonym: "benign tumor of parotid" EXACT [NCIT:C4770] +synonym: "benign tumor of parotid gland" EXACT [NCIT:C4770] +synonym: "benign tumor of the parotid" EXACT [NCIT:C4770] +synonym: "benign tumor of the parotid gland" EXACT [NCIT:C4770] +synonym: "parotid gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D11.0 {source="MONDO:equivalentTo"} +xref: NCIT:C4770 {source="MONDO:equivalentTo"} +xref: SCTID:92279000 {source="MONDO:equivalentTo"} +xref: UMLS:C0496857 {source="NCIT:C4770", source="MONDO:equivalentTo"} +is_a: MONDO:0021243 {source="MONDO:Redundant", source="NCIT:C4770"} ! parotid gland neoplasm +is_a: MONDO:0021492 {source="MONDO:Redundant", source="NCIT:C4770"} ! benign neoplasm of major salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001831 ! parotid gland +property_value: exactMatch http://identifiers.org/snomedct/92279000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496857 +property_value: exactMatch https://icd.codes/icd10cm/D11.0 +property_value: exactMatch NCIT:C4770 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021495 +name: benign neoplasm of sublingual gland +def: "A benign neoplasm that involves the sublingual gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the sublingual gland" EXACT [NCIT:C4601] +synonym: "benign sublingual gland neoplasm" EXACT [NCIT:C4601] +synonym: "benign sublingual gland tumor" EXACT [NCIT:C4601] +synonym: "benign tumor of sublingual gland" EXACT [NCIT:C4601] +synonym: "benign tumor of the sublingual gland" EXACT [NCIT:C4601] +synonym: "sublingual gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4601 {source="MONDO:equivalentTo"} +xref: SCTID:92413008 {source="MONDO:equivalentTo"} +xref: UMLS:C0347208 {source="MONDO:equivalentTo", source="NCIT:C4601"} +is_a: MONDO:0021242 {source="MONDO:Redundant", source="NCIT:C4601"} ! sublingual gland neoplasm +is_a: MONDO:0021492 {source="MONDO:Redundant", source="NCIT:C4601"} ! benign neoplasm of major salivary gland +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001832 ! sublingual gland +property_value: exactMatch http://identifiers.org/snomedct/92413008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347208 +property_value: exactMatch NCIT:C4601 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021496 +name: benign neoplasm of lip +def: "A benign neoplasm that involves the lip." [MONDO:patterns/location] +synonym: "benign Lip neoplasm" EXACT [NCIT:C3591] +synonym: "benign Lip tumor" EXACT [NCIT:C3591] +synonym: "benign neoplasm of the Lip" EXACT [NCIT:C3591] +synonym: "benign tumor of Lip" EXACT [NCIT:C3591] +synonym: "benign tumor of the Lip" EXACT [NCIT:C3591] +synonym: "lip benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "lip neoplasm, benign" EXACT [NCIT:C3591] +xref: ICD10CM:D10.0 {source="MONDO:equivalentTo"} +xref: ICD9:210.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3591 {source="MONDO:equivalentTo"} +xref: SCTID:92185002 {source="MONDO:equivalentTo"} +xref: UMLS:C0153932 {source="NCIT:C3591", source="MONDO:equivalentTo"} +is_a: MONDO:0000652 ! integumentary system benign neoplasm +is_a: MONDO:0021249 {source="MONDO:Redundant", source="NCIT:C3591"} ! lip neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001833 ! lip +property_value: exactMatch http://identifiers.org/snomedct/92185002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153932 +property_value: exactMatch https://icd.codes/icd10cm/D10.0 +property_value: exactMatch NCIT:C3591 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021497 +name: benign neoplasm of cerebrum +def: "A benign neoplasm that involves the telencephalon." [MONDO:patterns/location] +synonym: "benign cerebral hemispheric neoplasm" EXACT [NCIT:C8548] +synonym: "benign cerebral hemispheric tumor" EXACT [NCIT:C8548] +synonym: "benign cerebral neoplasm" EXACT [NCIT:C8548] +synonym: "benign cerebral tumor" EXACT [NCIT:C8548] +synonym: "benign neoplasm of cerebral hemispheres" EXACT [NCIT:C8548] +synonym: "benign neoplasm of the cerebral hemispheres" EXACT [NCIT:C8548] +synonym: "benign neoplasm of the cerebrum" EXACT [NCIT:C8548] +synonym: "benign tumor of cerebral hemispheres" EXACT [NCIT:C8548] +synonym: "benign tumor of cerebrum" EXACT [NCIT:C8548] +synonym: "benign tumor of the cerebral hemispheres" EXACT [NCIT:C8548] +synonym: "benign tumor of the cerebrum" EXACT [NCIT:C8548] +synonym: "telencephalon benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8548 {source="MONDO:equivalentTo"} +xref: SCTID:275269004 {source="MONDO:equivalentTo"} +xref: UMLS:C0686378 {source="MONDO:equivalentTo", source="NCIT:C8548"} +is_a: MONDO:0021374 {source="MONDO:Entailed", source="NCIT:C8548", source="NCIT:C8548/inferred"} ! neoplasm of cerebral hemisphere +is_a: MONDO:0021451 {source="MONDO:Redundant", source="NCIT:C8548/inferred"} ! benign neoplasm of brain +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001893 ! telencephalon +relationship: disease_has_location UBERON:0001893 ! telencephalon +property_value: exactMatch http://identifiers.org/snomedct/275269004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686378 +property_value: exactMatch NCIT:C8548 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021498 +name: benign neoplasm of placenta +def: "A benign neoplasm that involves the placenta." [MONDO:patterns/location] +synonym: "benign neoplasm of the placenta" EXACT [NCIT:C8545] +synonym: "benign placenta neoplasm" EXACT [NCIT:C8545] +synonym: "benign placenta tumor" EXACT [NCIT:C8545] +synonym: "benign placental neoplasm" EXACT [NCIT:C8545] +synonym: "benign placental tumor" EXACT [NCIT:C8545] +synonym: "benign tumor of placenta" EXACT [NCIT:C8545] +synonym: "benign tumor of the placenta" EXACT [NCIT:C8545] +synonym: "placenta benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "placental neoplasms, benign" EXACT [NCIT:C8545] +xref: ICD9:219.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C8545 {source="MONDO:equivalentTo"} +xref: SCTID:92297008 {source="MONDO:equivalentTo"} +xref: UMLS:C0686274 {source="MONDO:equivalentTo", source="NCIT:C8545"} +is_a: MONDO:0000632 ! uterine benign neoplasm +is_a: MONDO:0021218 {source="MONDO:Redundant", source="NCIT:C8545"} ! placenta neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001987 ! placenta +property_value: exactMatch http://identifiers.org/snomedct/92297008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686274 +property_value: exactMatch NCIT:C8545 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021499 +name: benign neoplasm of cerebellum +def: "A benign neoplasm that involves the cerebellum." [MONDO:patterns/location] +synonym: "benign cerebellar neoplasm" EXACT [NCIT:C4955] +synonym: "benign cerebellar neoplasms" EXACT [NCIT:C4955] +synonym: "benign cerebellar tumor" EXACT [NCIT:C4955] +synonym: "benign neoplasm of the cerebellum" EXACT [NCIT:C4955] +synonym: "benign tumor of cerebellum" EXACT [NCIT:C4955] +synonym: "benign tumor of the cerebellum" EXACT [NCIT:C4955] +synonym: "cerebellar neoplasms, benign" EXACT [NCIT:C4955] +synonym: "cerebellum benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "neoplasms, benign, cerebellar" EXACT [NCIT:C4955] +synonym: "neoplasms, cerebellar, benign" EXACT [NCIT:C4955] +xref: NCIT:C4955 {source="MONDO:equivalentTo"} +xref: SCTID:92050000 {source="MONDO:equivalentTo"} +is_a: MONDO:0002913 {source="MONDO:Redundant", source="NCIT:C4955"} ! cerebellar neoplasm +is_a: MONDO:0021451 {source="MONDO:Redundant", source="NCIT:C4955/inferred"} ! benign neoplasm of brain +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch http://identifiers.org/snomedct/92050000 +property_value: exactMatch NCIT:C4955 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021500 +name: benign neoplasm of spleen +def: "A benign neoplasm that involves the spleen." [MONDO:patterns/location] +synonym: "benign neoplasm of the spleen" EXACT [NCIT:C4902] +synonym: "benign splenic neoplasm" EXACT [NCIT:C4902] +synonym: "spleen benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:211.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4902 {source="MONDO:equivalentTo"} +xref: SCTID:92408009 {source="MONDO:equivalentTo"} +xref: UMLS:C0686615 {source="MONDO:equivalentTo", source="NCIT:C4902"} +is_a: MONDO:0000630 ! immune system organ benign neoplasm +is_a: MONDO:0036696 ! spleen neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002106 ! spleen +property_value: exactMatch http://identifiers.org/snomedct/92408009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686615 +property_value: exactMatch NCIT:C4902 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021501 +name: benign neoplasm of small intestine +def: "A benign neoplasm that involves the small intestine." [MONDO:patterns/location] +synonym: "benign neoplasm of the small intestine" EXACT [NCIT:C3600] +synonym: "benign small intestinal neoplasm" EXACT [NCIT:C3600] +synonym: "benign small intestinal tumor" EXACT [NCIT:C3600] +synonym: "benign small intestine neoplasm" EXACT [NCIT:C3600] +synonym: "benign small intestine tumor" EXACT [NCIT:C3600] +synonym: "benign tumor of small intestine" EXACT [NCIT:C3600] +synonym: "benign tumor of the small intestine" EXACT [NCIT:C3600] +synonym: "small intestine benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:211.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3600 {source="MONDO:equivalentTo"} +xref: SCTID:92385005 {source="MONDO:equivalentTo"} +xref: UMLS:C0153944 {source="MONDO:equivalentTo", source="NCIT:C3600"} +is_a: MONDO:0003062 {source="MONDO:Redundant", source="NCIT:C3600"} ! intestinal benign neoplasm +is_a: MONDO:0004251 {source="MONDO:Redundant", source="NCIT:C3600"} ! small intestine neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch http://identifiers.org/snomedct/92385005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153944 +property_value: exactMatch NCIT:C3600 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021503 +name: benign neoplasm of gallbladder +def: "A benign neoplasm that involves the gall bladder." [MONDO:patterns/location] +synonym: "benign gallbladder neoplasm" EXACT [NCIT:C4440] +synonym: "benign gallbladder tumor" EXACT [NCIT:C4440] +synonym: "benign neoplasm of the gallbladder" EXACT [NCIT:C4440] +synonym: "benign tumor of gallbladder" EXACT [NCIT:C4440] +synonym: "benign tumor of the gallbladder" EXACT [NCIT:C4440] +synonym: "gall bladder benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "gallbladder benign neoplasm" EXACT [NCIT:C4440] +synonym: "gallbladder benign tumor" EXACT [NCIT:C4440] +xref: DOID:0080640 {source="MONDO:equivalentTo"} +xref: NCIT:C4440 {source="MONDO:equivalentTo"} +xref: SCTID:92117002 {source="MONDO:equivalentTo"} +xref: UMLS:C0345912 {source="NCIT:C4440", source="MONDO:equivalentTo"} +is_a: MONDO:0000385 {source="MONDO:Entailed", source="NCIT:C4440"} ! benign digestive system neoplasm +is_a: MONDO:0021253 {source="MONDO:Redundant", source="NCIT:C4440"} ! gallbladder neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch DOID:0080640 +property_value: exactMatch http://identifiers.org/snomedct/92117002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345912 +property_value: exactMatch NCIT:C4440 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021505 +name: benign neoplasm of endocardium +def: "A benign neoplasm that involves the endocardium." [MONDO:patterns/location] +synonym: "benign endocardial neoplasm" EXACT [NCIT:C4608] +synonym: "benign endocardial tumor" EXACT [NCIT:C4608] +synonym: "benign neoplasm of the endocardium" EXACT [NCIT:C4608] +synonym: "benign tumor of endocardium" EXACT [NCIT:C4608] +synonym: "benign tumor of the endocardium" EXACT [NCIT:C4608] +synonym: "endocardium benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4608 {source="MONDO:equivalentTo"} +xref: SCTID:92083007 {source="MONDO:equivalentTo"} +xref: UMLS:C0347254 {source="NCIT:C4608", source="MONDO:equivalentTo"} +is_a: MONDO:0021378 {source="MONDO:Redundant", source="NCIT:C4608"} ! neoplasm of endocardium +is_a: MONDO:0021450 {source="MONDO:Redundant", source="NCIT:C4608"} ! benign neoplasm of heart +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002165 ! endocardium +property_value: exactMatch http://identifiers.org/snomedct/92083007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347254 +property_value: exactMatch NCIT:C4608 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021506 +name: benign neoplasm of spinal cord +def: "A benign neoplasm that involves the spinal cord." [MONDO:patterns/location] +synonym: "benign neoplasm of the spinal cord" EXACT [NCIT:C3627] +synonym: "benign spinal cord neoplasm" EXACT [NCIT:C3627] +synonym: "benign spinal cord tumor" EXACT [NCIT:C3627] +synonym: "benign tumor of spinal cord" EXACT [NCIT:C3627] +synonym: "benign tumor of the spinal cord" EXACT [NCIT:C3627] +synonym: "spinal cord benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "spinal cord neoplasm, benign" EXACT [NCIT:C3627] +xref: ICD10CM:D33.4 {source="MONDO:equivalentTo"} +xref: ICD9:225.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3627 {source="MONDO:equivalentTo"} +xref: SCTID:92405007 {source="MONDO:equivalentTo"} +xref: UMLS:C0154034 {source="NCIT:C3627", source="MONDO:equivalentTo"} +is_a: MONDO:0000628 ! central nervous system organ benign neoplasm +is_a: MONDO:0021234 {source="MONDO:Redundant", source="NCIT:C3627"} ! spinal cord neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch http://identifiers.org/snomedct/92405007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154034 +property_value: exactMatch https://icd.codes/icd10cm/D33.4 +property_value: exactMatch NCIT:C3627 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021507 +name: benign neoplasm of brain stem +def: "A benign neoplasm that involves the brainstem." [MONDO:patterns/location] +synonym: "benign brain stem neoplasm" EXACT [NCIT:C8549] +synonym: "benign brain stem neoplasms" EXACT [NCIT:C8549] +synonym: "benign brain stem tumor" EXACT [NCIT:C8549] +synonym: "benign brainstem neoplasm" EXACT [NCIT:C8549] +synonym: "benign brainstem neoplasms" EXACT [NCIT:C8549] +synonym: "benign brainstem tumor" EXACT [NCIT:C8549] +synonym: "benign brainstem tumors" EXACT [NCIT:C8549] +synonym: "benign neoplasm of brainstem" EXACT [NCIT:C8549] +synonym: "benign neoplasm of the brain stem" EXACT [NCIT:C8549] +synonym: "benign neoplasm of the brainstem" EXACT [NCIT:C8549] +synonym: "benign neoplasms of brainstem" EXACT [NCIT:C8549] +synonym: "benign neoplasms of the brainstem" EXACT [NCIT:C8549] +synonym: "benign tumor of brain stem" EXACT [NCIT:C8549] +synonym: "benign tumor of brainstem" EXACT [NCIT:C8549] +synonym: "benign tumor of the brain stem" EXACT [NCIT:C8549] +synonym: "benign tumor of the brainstem" EXACT [NCIT:C8549] +synonym: "benign tumors of brainstem" EXACT [NCIT:C8549] +synonym: "benign tumors of the brainstem" EXACT [NCIT:C8549] +synonym: "brainstem benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8549 {source="MONDO:equivalentTo"} +xref: SCTID:92029009 {source="MONDO:equivalentTo"} +xref: UMLS:C0686400 {source="MONDO:equivalentTo", source="NCIT:C8549"} +is_a: MONDO:0021228 {source="MONDO:Redundant", source="NCIT:C8549/inferred"} ! brainstem neoplasm +is_a: MONDO:0021451 {source="MONDO:Redundant", source="NCIT:C8549/inferred"} ! benign neoplasm of brain +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002298 ! brainstem +property_value: exactMatch http://identifiers.org/snomedct/92029009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0686400 +property_value: exactMatch NCIT:C8549 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021508 +name: benign neoplasm of epicardium +def: "A benign neoplasm that involves the epicardium." [MONDO:patterns/location] +synonym: "benign epicardial neoplasm" EXACT [NCIT:C8535] +synonym: "benign epicardial tumor" EXACT [NCIT:C8535] +synonym: "benign neoplasm of the epicardium" EXACT [NCIT:C8535] +synonym: "benign tumor of epicardium" EXACT [NCIT:C8535] +synonym: "benign tumor of the epicardium" EXACT [NCIT:C8535] +synonym: "epicardium benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8535 {source="MONDO:equivalentTo"} +xref: SCTID:92087008 {source="MONDO:equivalentTo"} +xref: UMLS:C0685115 {source="MONDO:equivalentTo", source="NCIT:C8535"} +is_a: MONDO:0021379 {source="MONDO:Redundant", source="NCIT:C8535"} ! neoplasm of epicardium +is_a: MONDO:0021450 {source="MONDO:Redundant", source="NCIT:C8535"} ! benign neoplasm of heart +is_a: MONDO:0021514 {source="MONDO:Redundant"} ! benign neoplasm of pericardium +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002348 ! epicardium +property_value: exactMatch http://identifiers.org/snomedct/92087008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0685115 +property_value: exactMatch NCIT:C8535 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021509 +name: benign neoplasm of myocardium +def: "A benign neoplasm that involves the myocardium." [MONDO:patterns/location] +synonym: "benign myocardial neoplasm" EXACT [NCIT:C4607] +synonym: "benign myocardial tumor" EXACT [NCIT:C4607] +synonym: "benign neoplasm of the myocardium" EXACT [NCIT:C4607] +synonym: "benign tumor of myocardium" EXACT [NCIT:C4607] +synonym: "benign tumor of the myocardium" EXACT [NCIT:C4607] +synonym: "myocardium benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4607 {source="MONDO:equivalentTo"} +xref: SCTID:92238001 {source="MONDO:equivalentTo"} +xref: UMLS:C0347253 {source="NCIT:C4607", source="MONDO:equivalentTo"} +is_a: MONDO:0000636 ! musculoskeletal system benign neoplasm +is_a: MONDO:0021380 {source="MONDO:Redundant", source="NCIT:C4607"} ! neoplasm of myocardium +is_a: MONDO:0021450 {source="MONDO:Redundant", source="NCIT:C4607"} ! benign neoplasm of heart +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002349 ! myocardium +property_value: exactMatch http://identifiers.org/snomedct/92238001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347253 +property_value: exactMatch NCIT:C4607 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021510 +name: benign neoplasm of prostate +def: "A benign neoplasm that involves the prostate gland." [MONDO:patterns/location] +synonym: "benign neoplasm of the prostate" EXACT [NCIT:C3613] +synonym: "benign prostate neoplasm" EXACT [NCIT:C3613] +synonym: "benign prostate tumor" EXACT [NCIT:C3613] +synonym: "benign prostatic neoplasm" EXACT [NCIT:C3613] +synonym: "benign tumor of prostate" EXACT [NCIT:C3613] +synonym: "benign tumor of the prostate" EXACT [NCIT:C3613] +synonym: "prostate gland benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D29.1 {source="MONDO:equivalentTo"} +xref: ICD9:222.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3613 {source="MONDO:equivalentTo"} +xref: SCTID:92308005 {source="MONDO:equivalentTo"} +xref: UMLS:C0154009 {source="MONDO:equivalentTo", source="NCIT:C3613"} +is_a: MONDO:0000625 ! benign male reproductive system neoplasm +is_a: MONDO:0021259 {source="MONDO:Redundant", source="NCIT:C3613"} ! prostate neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002367 ! prostate gland +property_value: exactMatch http://identifiers.org/snomedct/92308005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154009 +property_value: exactMatch https://icd.codes/icd10cm/D29.1 +property_value: exactMatch NCIT:C3613 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021511 +name: benign neoplasm of adrenal gland +def: "A benign neoplasm that involves the adrenal gland." [MONDO:patterns/location] +synonym: "adrenal gland benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "benign adrenal gland neoplasm" EXACT [NCIT:C3629] +synonym: "benign adrenal gland tumor" EXACT [NCIT:C3629] +synonym: "benign adrenal neoplasm" EXACT [NCIT:C3629] +synonym: "benign adrenal tumor" EXACT [NCIT:C3629] +synonym: "benign neoplasm of the adrenal gland" EXACT [NCIT:C3629] +synonym: "benign tumor of adrenal gland" EXACT [NCIT:C3629] +synonym: "benign tumor of the adrenal gland" EXACT [NCIT:C3629] +xref: ICD9:227.0 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3629 {source="MONDO:equivalentTo"} +xref: SCTID:91967007 {source="MONDO:equivalentTo"} +xref: UMLS:C0154040 {source="NCIT:C3629", source="MONDO:equivalentTo"} +is_a: MONDO:0000627 {source="MONDO:Redundant"} ! benign endocrine neoplasm +is_a: MONDO:0021227 {source="MONDO:Redundant", source="NCIT:C3629"} ! adrenal gland neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002369 ! adrenal gland +property_value: exactMatch http://identifiers.org/snomedct/91967007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154040 +property_value: exactMatch NCIT:C3629 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021512 +name: benign neoplasm of thymus +def: "A benign neoplasm that involves the thymus." [MONDO:patterns/location] +synonym: "benign neoplasm of the Thymus" EXACT [NCIT:C4458] +synonym: "benign thymic neoplasm" EXACT [NCIT:C4458] +synonym: "benign thymic tumor" EXACT [NCIT:C4458] +synonym: "benign Thymus neoplasm" EXACT [NCIT:C4458] +synonym: "benign Thymus tumor" EXACT [NCIT:C4458] +synonym: "benign tumor of the Thymus" EXACT [NCIT:C4458] +synonym: "benign tumor of Thymus" EXACT [NCIT:C4458] +synonym: "thymus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D15.0 {source="MONDO:equivalentTo"} +xref: ICD9:212.6 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C4458 {source="MONDO:equivalentTo"} +xref: SCTID:92437008 {source="MONDO:equivalentTo"} +xref: UMLS:C0345975 {source="MONDO:equivalentTo", source="NCIT:C4458"} +is_a: MONDO:0000627 ! benign endocrine neoplasm +is_a: MONDO:0000630 ! immune system organ benign neoplasm +is_a: MONDO:0005197 {source="MONDO:Redundant", source="NCIT:C4458"} ! thymus neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002370 ! thymus +property_value: exactMatch http://identifiers.org/snomedct/92437008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345975 +property_value: exactMatch https://icd.codes/icd10cm/D15.0 +property_value: exactMatch NCIT:C4458 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021513 +name: benign neoplasm of tonsil +def: "A benign neoplasm that involves the tonsil." [MONDO:patterns/location] +synonym: "benign neoplasm of the tonsil" EXACT [NCIT:C3594] +synonym: "benign tonsil neoplasm" EXACT [NCIT:C3594] +synonym: "benign tonsil tumor" EXACT [NCIT:C3594] +synonym: "benign tonsillar neoplasm" EXACT [NCIT:C3594] +synonym: "benign tonsillar tumor" EXACT [NCIT:C3594] +synonym: "benign tumor of the tonsil" EXACT [NCIT:C3594] +synonym: "benign tumor of tonsil" EXACT [NCIT:C3594] +synonym: "tonsil benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "tonsillar neoplasm, benign" EXACT [NCIT:C3594] +xref: ICD10CM:D10.4 {source="MONDO:equivalentTo"} +xref: ICD9:210.5 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3594 {source="MONDO:equivalentTo"} +xref: SCTID:92263001 {source="MONDO:equivalentTo"} +xref: UMLS:C0153936 {source="NCIT:C3594", source="MONDO:equivalentTo"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0021250 {source="MONDO:Redundant", source="NCIT:C3594"} ! tonsil neoplasm +is_a: MONDO:0021523 {source="MONDO:Redundant", source="NCIT:C3594/inferred"} ! benign neoplasm of pharynx +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002372 ! tonsil +property_value: exactMatch http://identifiers.org/snomedct/92263001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153936 +property_value: exactMatch https://icd.codes/icd10cm/D10.4 +property_value: exactMatch NCIT:C3594 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021514 +name: benign neoplasm of pericardium +def: "A benign neoplasm that involves the pericardium." [MONDO:patterns/location] +synonym: "benign neoplasm of the pericardium" EXACT [NCIT:C8536] +synonym: "benign pericardial neoplasm" EXACT [NCIT:C8536] +synonym: "benign pericardial tumor" EXACT [NCIT:C8536] +synonym: "benign tumor of pericardium" EXACT [NCIT:C8536] +synonym: "benign tumor of the pericardium" EXACT [NCIT:C8536] +synonym: "pericardium benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C8536 {source="MONDO:equivalentTo"} +xref: SCTID:92289001 {source="MONDO:equivalentTo"} +xref: UMLS:C0685118 {source="MONDO:equivalentTo", source="NCIT:C8536"} +is_a: MONDO:0000629 ! cardiovascular organ benign neoplasm +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C8536", source="NCIT:C8536/inferred"} ! thoracic benign neoplasm +is_a: MONDO:0021381 {source="MONDO:Redundant", source="NCIT:C8536"} ! neoplasm of pericardium +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002407 ! pericardium +property_value: exactMatch http://identifiers.org/snomedct/92289001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0685118 +property_value: exactMatch NCIT:C8536 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021515 +name: benign neoplasm of ethmoidal sinus +def: "A benign neoplasm that involves the ethmoid sinus." [MONDO:patterns/location] +synonym: "benign ethmoid sinus neoplasm" EXACT [NCIT:C4417] +synonym: "benign ethmoid sinus tumor" EXACT [NCIT:C4417] +synonym: "benign ethmoidal sinus neoplasm" EXACT [NCIT:C4417] +synonym: "benign ethmoidal sinus tumor" EXACT [NCIT:C4417] +synonym: "benign neoplasm of ethmoid sinus" EXACT [NCIT:C4417] +synonym: "benign neoplasm of the ethmoid sinus" EXACT [NCIT:C4417] +synonym: "benign neoplasm of the ethmoidal sinus" EXACT [NCIT:C4417] +synonym: "benign tumor of ethmoid sinus" EXACT [NCIT:C4417] +synonym: "benign tumor of ethmoidal sinus" EXACT [NCIT:C4417] +synonym: "benign tumor of the ethmoid sinus" EXACT [NCIT:C4417] +synonym: "benign tumor of the ethmoidal sinus" EXACT [NCIT:C4417] +synonym: "ethmoid sinus benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:212.0 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4417 {source="MONDO:equivalentTo"} +xref: SCTID:92093000 {source="MONDO:equivalentTo"} +xref: UMLS:C0345670 {source="MONDO:equivalentTo", source="NCIT:C4417"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0000633 ! sensory organ benign neoplasm +is_a: MONDO:0001764 {source="MONDO:Redundant", source="NCIT:C4417"} ! ethmoidal sinus neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002453 ! ethmoid sinus +property_value: exactMatch http://identifiers.org/snomedct/92093000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345670 +property_value: exactMatch NCIT:C4417 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021516 +name: benign neoplasm of glottis +def: "A benign neoplasm that involves the glottis." [MONDO:patterns/location] +synonym: "benign glottis neoplasm" EXACT [NCIT:C4605] +synonym: "benign glottis tumor" EXACT [NCIT:C4605] +synonym: "benign neoplasm of the glottis" EXACT [NCIT:C4605] +synonym: "benign tumor of glottis" EXACT [NCIT:C4605] +synonym: "benign tumor of the glottis" EXACT [NCIT:C4605] +synonym: "glottis benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4605 {source="MONDO:equivalentTo"} +xref: SCTID:92123007 {source="MONDO:equivalentTo"} +xref: UMLS:C0347234 {source="MONDO:equivalentTo", source="NCIT:C4605"} +is_a: MONDO:0002353 {source="MONDO:Redundant", source="NCIT:C4605"} ! glottis neoplasm +is_a: MONDO:0002354 {source="MONDO:Redundant", source="NCIT:C4605"} ! benign laryngeal neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0002486 ! glottis +property_value: exactMatch http://identifiers.org/snomedct/92123007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347234 +property_value: exactMatch NCIT:C4605 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021517 +name: benign neoplasm of trachea +def: "A benign neoplasm that involves the trachea." [MONDO:patterns/location] +synonym: "benign neoplasm of the trachea" EXACT [NCIT:C3602] +synonym: "benign trachea neoplasm" EXACT [NCIT:C3602] +synonym: "benign trachea tumor" EXACT [NCIT:C3602] +synonym: "benign tracheal neoplasm" EXACT [NCIT:C3602] +synonym: "benign tracheal tumor" EXACT [NCIT:C3602] +synonym: "benign tumor of the trachea" EXACT [NCIT:C3602] +synonym: "benign tumor of trachea" EXACT [NCIT:C3602] +synonym: "trachea benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D14.2 {source="MONDO:equivalentTo"} +xref: ICD9:212.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3602 {source="MONDO:equivalentTo"} +xref: SCTID:92446002 {source="MONDO:equivalentTo"} +xref: UMLS:C0153953 {source="MONDO:equivalentTo", source="NCIT:C3602"} +is_a: MONDO:0000382 {source="MONDO:Redundant"} ! respiratory system benign neoplasm +is_a: MONDO:0021210 {source="MONDO:Redundant", source="NCIT:C3602"} ! trachea neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003126 ! trachea +property_value: exactMatch http://identifiers.org/snomedct/92446002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153953 +property_value: exactMatch https://icd.codes/icd10cm/D14.2 +property_value: exactMatch NCIT:C3602 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021518 +name: benign neoplasm of hard palate +def: "A benign neoplasm that involves the hard palate." [MONDO:patterns/location] +synonym: "benign hard palate neoplasm" EXACT [NCIT:C4403] +synonym: "benign hard palate tumor" EXACT [NCIT:C4403] +synonym: "benign neoplasm of the hard palate" EXACT [NCIT:C4403] +synonym: "benign tumor of hard palate" EXACT [NCIT:C4403] +synonym: "benign tumor of the hard palate" EXACT [NCIT:C4403] +synonym: "hard palate benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4403 {source="MONDO:equivalentTo"} +xref: SCTID:92129006 {source="MONDO:equivalentTo"} +xref: UMLS:C0345552 {source="MONDO:equivalentTo", source="NCIT:C4403"} +is_a: MONDO:0005286 ! palatal neoplasm +is_a: MONDO:0021445 ! benign neoplasm of oral cavity +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003216 ! hard palate +relationship: disease_has_location UBERON:0003216 ! hard palate +property_value: exactMatch http://identifiers.org/snomedct/92129006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345552 +property_value: exactMatch NCIT:C4403 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021520 +name: benign neoplasm of floor of mouth +def: "A benign neoplasm that involves the mouth floor." [MONDO:patterns/location] +synonym: "benign floor of mouth neoplasm" EXACT [NCIT:C3593] +synonym: "benign floor of mouth tumor" EXACT [NCIT:C3593] +synonym: "benign floor of the mouth neoplasm" EXACT [NCIT:C3593] +synonym: "benign floor of the mouth tumor" EXACT [NCIT:C3593] +synonym: "benign neoplasm of the floor of the mouth" EXACT [NCIT:C3593] +synonym: "benign tumor of floor of mouth" EXACT [NCIT:C3593] +synonym: "benign tumor of the floor of the mouth" EXACT [NCIT:C3593] +synonym: "mouth floor benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D10.2 {source="MONDO:equivalentTo"} +xref: ICD9:210.3 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3593 {source="MONDO:equivalentTo"} +xref: SCTID:92109005 {source="MONDO:equivalentTo"} +xref: UMLS:C0153934 {source="NCIT:C3593", source="MONDO:equivalentTo"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0021383 {source="MONDO:Redundant", source="NCIT:C3593"} ! neoplasm of floor of mouth +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003679 ! mouth floor +property_value: exactMatch http://identifiers.org/snomedct/92109005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153934 +property_value: exactMatch https://icd.codes/icd10cm/D10.2 +property_value: exactMatch NCIT:C3593 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021521 +name: benign neoplasm of mediastinum +def: "A benign neoplasm that involves the mediastinum." [MONDO:patterns/location] +synonym: "benign mediastinal neoplasm" EXACT [NCIT:C3604] +synonym: "benign mediastinal tumor" EXACT [NCIT:C3604] +synonym: "benign neoplasm of the mediastinum" EXACT [NCIT:C3604] +synonym: "benign tumor of mediastinum" EXACT [NCIT:C3604] +synonym: "benign tumor of the mediastinum" EXACT [NCIT:C3604] +synonym: "mediastinum benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D15.2 {source="MONDO:equivalentTo"} +xref: ICD9:212.5 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3604 {source="MONDO:equivalentTo"} +xref: SCTID:92214000 {source="MONDO:equivalentTo"} +xref: UMLS:C0153956 {source="MONDO:equivalentTo", source="NCIT:C3604"} +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C3604"} ! thoracic benign neoplasm +is_a: MONDO:0021386 {source="MONDO:Redundant", source="NCIT:C3604"} ! neoplasm of mediastinum +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0003728 ! mediastinum +property_value: exactMatch http://identifiers.org/snomedct/92214000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153956 +property_value: exactMatch https://icd.codes/icd10cm/D15.2 +property_value: exactMatch NCIT:C3604 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021522 +name: benign neoplasm of lower jaw bone +def: "A benign neoplasm that involves the bone of lower jaw." [MONDO:patterns/location] +synonym: "bone of lower jaw benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD10CM:D16.5 {source="MONDO:equivalentTo"} +xref: ICD9:213.1 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C34417 {source="MONDO:equivalentTo"} +xref: SCTID:92208007 {source="MONDO:equivalentTo"} +xref: UMLS:C0004994 {source="MONDO:equivalentTo", source="NCIT:C34417"} +is_a: MONDO:0000631 ! bone benign neoplasm +is_a: MONDO:0021580 {source="MONDO:Redundant"} ! neoplasm of jaw +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0004768 ! bone of lower jaw +relationship: disease_has_location UBERON:0004768 ! bone of lower jaw +property_value: exactMatch http://identifiers.org/snomedct/92208007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0004994 +property_value: exactMatch https://icd.codes/icd10cm/D16.5 +property_value: exactMatch NCIT:C34417 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021523 +name: benign neoplasm of pharynx +def: "A benign neoplasm that involves the pharynx." [MONDO:patterns/location] +synonym: "benign neoplasm of the pharynx" EXACT [NCIT:C3597] +synonym: "benign pharyngeal neoplasm" EXACT [NCIT:C3597] +synonym: "benign pharyngeal tumor" EXACT [NCIT:C3597] +synonym: "benign pharynx neoplasm" EXACT [NCIT:C3597] +synonym: "benign pharynx tumor" EXACT [NCIT:C3597] +synonym: "benign tumor of pharynx" EXACT [NCIT:C3597] +synonym: "benign tumor of the pharynx" EXACT [NCIT:C3597] +synonym: "pharyngeal neoplasm benign" EXACT [NCIT:C3597] +synonym: "pharynx benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:210.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C3597 {source="MONDO:equivalentTo"} +xref: SCTID:92293007 {source="MONDO:equivalentTo"} +xref: UMLS:C0153940 {source="MONDO:equivalentTo", source="NCIT:C3597"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0021246 {source="MONDO:Redundant", source="NCIT:C3597"} ! pharynx neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0006562 ! pharynx +property_value: exactMatch http://identifiers.org/snomedct/92293007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0153940 +property_value: exactMatch NCIT:C3597 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021527 +name: benign neoplasm of meninges +def: "A benign neoplasm that involves the meningeal cluster." [MONDO:patterns/location] +synonym: "benign meningeal neoplasm" EXACT [NCIT:C4957] +synonym: "benign meningeal neoplasms" EXACT [NCIT:C4957] +synonym: "benign meningeal tumor" EXACT [NCIT:C4957] +synonym: "benign meningeal tumors" EXACT [NCIT:C4957] +synonym: "benign meninges neoplasm" EXACT [NCIT:C4957] +synonym: "benign meninges tumor" EXACT [NCIT:C4957] +synonym: "benign neoplasm of the meninges" EXACT [NCIT:C4957] +synonym: "benign neoplasms of meninges" EXACT [NCIT:C4957] +synonym: "benign neoplasms of the meninges" EXACT [NCIT:C4957] +synonym: "benign tumor of meninges" EXACT [NCIT:C4957] +synonym: "benign tumor of the meninges" EXACT [NCIT:C4957] +synonym: "meningeal cluster benign neoplasm" EXACT [MONDO:patterns/location] +synonym: "meningeal tumors, benign" EXACT [NCIT:C4957] +xref: ICD10CM:D32 {source="MONDO:equivalentTo"} +xref: NCIT:C4957 {source="MONDO:equivalentTo"} +xref: SCTID:109913001 {source="MONDO:equivalentTo"} +xref: UMLS:C0348426 {source="MONDO:equivalentTo", source="NCIT:C4957"} +is_a: MONDO:0000628 ! central nervous system organ benign neoplasm +is_a: MONDO:0016743 {source="MONDO:Redundant", source="NCIT:C4957"} ! tumor of meninges +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0010743 ! meningeal cluster +property_value: exactMatch http://identifiers.org/snomedct/109913001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0348426 +property_value: exactMatch https://icd.codes/icd10cm/D32 +property_value: exactMatch NCIT:C4957 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021528 +name: benign neoplasm of male breast +def: "A non-metastasizing neoplasm that arises from the breast parenchyma in males." [NCIT:C4620] +synonym: "benign Male breast neoplasm" EXACT [NCIT:C4620] +synonym: "benign Male breast tumor" EXACT [NCIT:C4620] +synonym: "benign neoplasm of the Male breast" EXACT [NCIT:C4620] +synonym: "benign tumor of Male breast" EXACT [NCIT:C4620] +synonym: "benign tumor of the Male breast" EXACT [NCIT:C4620] +synonym: "male breast benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4620 {source="MONDO:equivalentTo"} +xref: SCTID:92206006 {source="MONDO:equivalentTo"} +xref: UMLS:C0347482 {source="MONDO:equivalentTo", source="NCIT:C4620"} +is_a: MONDO:0000620 {source="MONDO:Redundant", source="NCIT:C4620"} ! breast benign neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0016410 ! male breast +relationship: disease_has_location UBERON:0016410 ! male breast +property_value: exactMatch http://identifiers.org/snomedct/92206006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0347482 +property_value: exactMatch NCIT:C4620 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021529 +name: benign neoplasm of chest wall +def: "A benign neoplasm that involves the chest wall." [MONDO:patterns/location] +synonym: "benign chest wall neoplasm" EXACT [NCIT:C8529] +synonym: "benign chest wall tumor" EXACT [NCIT:C8529] +synonym: "benign neoplasm of the chest wall" EXACT [NCIT:C8529] +synonym: "benign tumor of chest wall" EXACT [NCIT:C8529] +synonym: "benign tumor of the chest wall" EXACT [NCIT:C8529] +synonym: "chest wall benign neoplasm" EXACT [MONDO:patterns/location] +xref: ICD9:229.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C8529 {source="MONDO:equivalentTo"} +xref: SCTID:92058007 {source="MONDO:equivalentTo"} +xref: UMLS:C0684831 {source="MONDO:equivalentTo", source="NCIT:C8529"} +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C8529"} ! thoracic benign neoplasm +is_a: MONDO:0021388 {source="MONDO:Redundant", source="NCIT:C8529"} ! neoplasm of chest wall +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0016435 ! chest wall +property_value: exactMatch http://identifiers.org/snomedct/92058007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684831 +property_value: exactMatch NCIT:C8529 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021533 +name: intestinal neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C4637] +synonym: "carcinoid tumor of intestine" EXACT [NCIT:C4637] +synonym: "carcinoid tumor of the intestine" EXACT [NCIT:C4637] +synonym: "grade 1 neuroendocrine neoplasm of intestine" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "intestinal carcinoid tumor" EXACT [NCIT:C4637] +synonym: "intestinal NET G1" EXACT [NCIT:C4637] +synonym: "intestinal neuroendocrine tumor G1" EXACT [NCIT:C4637] +synonym: "intestine carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1, NCIT:C4637] +synonym: "intestine carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "intestine NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "intestine neuroendocrine neoplasm G1" EXACT [] +synonym: "intestine neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: MESH:C562842 {source="MONDO:equivalentTo"} +xref: NCIT:C4637 {source="MONDO:equivalentTo"} +xref: OMIM:114900 {source="MONDO:equivalentTo"} +xref: SCTID:276816003 {source="MONDO:equivalentTo"} +xref: UMLS:C0349535 {source="MONDO:equivalentTo", source="MONDO:notFoundInDiseaseSubset", source="OMIM:114900", source="NCIT:C4637"} +is_a: MONDO:0000386 ! digestive system neuroendocrine tumor, grade 1/2 +is_a: MONDO:0002883 {source="MONDO:Redundant", source="NCIT:C4637/inferred"} ! intestinal neuroendocrine neoplasm +is_a: MONDO:0005369 {source="NCIT:C4637/inferred"} ! carcinoid tumor +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000160 ! intestine +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +relationship: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://identifiers.org/mesh/C562842 +property_value: exactMatch http://identifiers.org/snomedct/276816003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349535 +property_value: exactMatch https://omim.org/entry/114900 +property_value: exactMatch NCIT:C4637 +property_value: excluded_subClassOf MONDO:0003847 {source="OMIM:114900"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4207 + +[Term] +id: MONDO:0021534 +name: rectal neuroendocrine tumor G1 +def: "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent." [NCIT:C5547] +synonym: "carcinoid of rectum" EXACT [NCIT:C5547] +synonym: "carcinoid of the rectum" EXACT [NCIT:C5547] +synonym: "carcinoid tumor of rectum" EXACT [NCIT:C5547] +synonym: "carcinoid tumor of the rectum" EXACT [NCIT:C5547] +synonym: "grade 1 neuroendocrine neoplasm of rectum" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "rectal carcinoid" EXACT [NCIT:C5547] +synonym: "rectal carcinoid tumor" EXACT [NCIT:C5547] +synonym: "rectal NET G1" EXACT [NCIT:C5547] +synonym: "rectal neuroendocrine tumor G1" EXACT [NCIT:C5547] +synonym: "rectum carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "rectum carcinoid tumor (disease)" EXACT [MONDO:patterns/location] +synonym: "rectum NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "rectum neuroendocrine neoplasm G1" EXACT [] +synonym: "rectum neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +xref: NCIT:C5547 {source="MONDO:equivalentTo"} +xref: SCTID:713306000 {source="MONDO:equivalentTo"} +xref: UMLS:C1335678 {source="MONDO:equivalentTo", source="NCIT:C5547"} +is_a: MONDO:0006162 {source="MONDO:Redundant", source="NCIT:C5547"} ! colorectal neuroendocrine tumor G1 +is_a: MONDO:0015068 {source="MONDO:Redundant", source="NCIT:C5547"} ! neuroendocrine tumor of rectum, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://identifiers.org/snomedct/713306000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335678 +property_value: exactMatch NCIT:C5547 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0021535 +name: pancreatic neuroendocrine tumor G1 +def: "A low grade well differentiated tumor with neuroendocrine differentiation that arises from the pancreas. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal or less than 2%." [NCIT:C95584] +synonym: "grade 1 neuroendocrine neoplasm of pancreas" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "pancreas carcinoid tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "pancreas NET G1" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "pancreas neuroendocrine neoplasm G1" EXACT [] +synonym: "pancreas neuroendocrine tumor, well differentiated, low grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm_grade1] +synonym: "pancreatic NET G1" EXACT [NCIT:C95584] +synonym: "pancreatic neuroendocrine tumor G1" EXACT [NCIT:C95584] +xref: NCIT:C95584 {source="MONDO:equivalentTo"} +xref: SCTID:254613007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005369 ! carcinoid tumor +is_a: MONDO:0019954 {source="NCIT:C95584"} ! pancreatic neuroendocrine tumor +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001264 ! pancreas +intersection_of: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +relationship: has_modifier MONDO:0024491 ! tumor grade 1, general grading system +property_value: exactMatch http://identifiers.org/snomedct/254613007 +property_value: exactMatch NCIT:C95584 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neuroendocrine_neoplasm_grade1.yaml + +[Term] +id: MONDO:0021545 +name: myomatous neoplasm +def: "A benign or malignant mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle." [NCIT:C4063] +synonym: "muscle neoplasm" EXACT [NCIT:C4063] +synonym: "muscle tissue neoplasm" RELATED [MESH:D009379] +synonym: "muscle tissue neoplasms" RELATED [MESH:D009379] +synonym: "muscle tumor" EXACT [NCIT:C4063] +synonym: "myoblastoma" RELATED [MESH:D009379] +synonym: "myoblastomas" RELATED [MESH:D009379] +synonym: "myofibroblastoma" RELATED [MESH:D009379] +synonym: "myofibroblastomas" RELATED [MESH:D009379] +synonym: "myomatous neoplasm" EXACT [NCIT:C4063] +synonym: "myomatous tumor" EXACT [NCIT:C4063] +synonym: "neoplasm of muscle" EXACT [NCIT:C4063] +synonym: "neoplasm of the muscle" EXACT [NCIT:C4063] +synonym: "neoplasm, muscle tissue" RELATED [MESH:D009379] +synonym: "tumor of muscle" EXACT [NCIT:C4063] +synonym: "tumor of the muscle" EXACT [NCIT:C4063] +xref: MESH:D009379 {source="MONDO:equivalentTo"} +xref: MESH:D019042 {source="MONDO:equivalentTo"} +xref: NCIT:C4063 {source="MONDO:equivalentTo"} +is_a: MONDO:0002616 {source="NCIT:C4063"} ! mesenchymal cell neoplasm +is_a: MONDO:0003939 ! muscle tissue disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000187 ! muscle cell +relationship: disease_arises_from_structure CL:0000187 ! muscle cell +property_value: exactMatch http://identifiers.org/mesh/D009379 +property_value: exactMatch http://identifiers.org/mesh/D019042 +property_value: exactMatch NCIT:C4063 + +[Term] +id: MONDO:0021546 +name: ependymal tumor of spinal cord +def: "An ependymal tumor that arises from the spinal cord." [NCIT:C131526] +synonym: "ependymal tumor of spinal cord" EXACT [NCIT:C131526] +synonym: "spinal cord ependymal tumor" EXACT [MONDO:patterns/location] +xref: NCIT:C131526 {source="MONDO:equivalentTo"} +xref: UMLS:C4318747 {source="MONDO:equivalentTo"} +is_a: MONDO:0002542 {source="NCIT:C131526"} ! spinal cord glioma +is_a: MONDO:0003266 {source="MONDO:Redundant", source="NCIT:C131526"} ! ependymal tumor +intersection_of: MONDO:0003266 ! ependymal tumor +intersection_of: disease_has_location UBERON:0002240 ! spinal cord +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4318747 +property_value: exactMatch NCIT:C131526 + +[Term] +id: MONDO:0021562 +name: omphalitis +def: "Inflammation of the umbilical cord stump in newborns." [NCIT:C116008] +synonym: "Omphalitis" RELATED [GTR:AN0533760, NCIT:C116008] +synonym: "omphalitis" EXACT [NCIT:C116008] +xref: GTR:AN0533760 {source="UMLS:C0028992"} +xref: NCIT:C116008 {source="UMLS:C0028992", source="MONDO:equivalentTo"} +xref: SCTID:239095007 {source="UMLS:C0028992", source="MONDO:equivalentTo"} +xref: UMLS:C0028992 {source="MONDO:equivalentTo"} +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002331 ! umbilical cord +relationship: disease_has_inflammation_site UBERON:0002331 ! umbilical cord +property_value: exactMatch http://identifiers.org/snomedct/239095007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0028992 +property_value: exactMatch NCIT:C116008 + +[Term] +id: MONDO:0021568 +name: renal tubule disorder +def: "A disease that involves the renal tubule." [MONDO:patterns/location] +synonym: "disease of renal tubule" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of renal tubule" EXACT [] +synonym: "disorder of renal tubule" EXACT [MONDO:patterns/location_top] +synonym: "renal tubular disease" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "renal tubular disorder" EXACT [https://orcid.org/0000-0002-6601-2165] +synonym: "renal tubule disease" EXACT [MONDO:patterns/location] +synonym: "renal tubule disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: ICD9:588.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:95568003 {source="MONDO:equivalentTo"} +xref: UMLS:C0151747 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 ! kidney disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0009773 ! renal tubule +relationship: disease_has_location UBERON:0009773 ! renal tubule +property_value: exactMatch http://identifiers.org/snomedct/95568003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151747 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0021576 +name: fallopian tube endometrioid tumor +def: "A benign, borderline, or malignant epithelial tumor of the fallopian tube that is characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells." [NCIT:C40111] +synonym: "endometrium neoplasm of fallopian tube" EXACT [MONDO:design_pattern] +synonym: "fallopian tube endometrioid neoplasm" EXACT [NCIT:C40111] +synonym: "fallopian tube endometrioid tumor" EXACT [NCIT:C40111] +synonym: "fallopian tube endometrium neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C40111 {source="MONDO:equivalentTo"} +xref: UMLS:C1517113 {source="MONDO:equivalentTo", source="NCIT:C40111"} +is_a: MONDO:0021092 {source="MONDO:Redundant", source="NCIT:C40111"} ! fallopian tube neoplasm +is_a: MONDO:0021251 ! endometrium neoplasm +intersection_of: MONDO:0021251 ! endometrium neoplasm +intersection_of: disease_has_location UBERON:0003889 ! fallopian tube +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1517113 +property_value: exactMatch NCIT:C40111 + +[Term] +id: MONDO:0021578 +name: sternal neoplasm +def: "A benign or malignant neoplasm that affects the sternum." [NCIT:C6730] +synonym: "neoplasm of sternum" EXACT [MONDO:patterns/neoplasm, NCIT:C6730] +synonym: "neoplasm of sternum (disease)" EXACT [] +synonym: "neoplasm of sternum (disorder)" EXACT [] +synonym: "neoplasm of the sternum" EXACT [NCIT:C6730] +synonym: "sternal neoplasm" EXACT [NCIT:C6730] +synonym: "sternal tumor" EXACT [NCIT:C6730] +synonym: "sternum neoplasm" EXACT [] +synonym: "sternum neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "sternum tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of sternum" EXACT [MONDO:patterns/neoplasm, NCIT:C6730] +synonym: "tumor of the sternum" EXACT [NCIT:C6730] +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C6730 {source="MONDO:equivalentTo"} +xref: SCTID:126559003 {source="MONDO:equivalentTo"} +xref: UMLS:C1290244 {source="MONDO:equivalentTo", source="NCIT:C6730"} +is_a: MONDO:0005172 ! skeletal system disorder +is_a: MONDO:0021350 {source="MONDO:Redundant", source="NCIT:C6730"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000975 ! sternum +relationship: disease_has_location UBERON:0000975 ! sternum +property_value: exactMatch http://identifiers.org/snomedct/126559003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290244 +property_value: exactMatch NCIT:C6730 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021579 +name: neoplasm of femur +def: "A neoplasm (disease) that involves the femur." [MONDO:patterns/location] +synonym: "femur neoplasm" EXACT [] +synonym: "femur neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "femur tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of femur" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of femur" EXACT [MONDO:patterns/neoplasm] +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:126583006 {source="MONDO:equivalentTo"} +is_a: MONDO:0019060 ! bone neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000981 ! femur +relationship: disease_has_location UBERON:0000981 ! femur +property_value: exactMatch http://identifiers.org/snomedct/126583006 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021580 +name: neoplasm of jaw +def: "A neoplasm (disease) that involves the jaw skeleton." [MONDO:patterns/location] +synonym: "jaw skeleton neoplasm" EXACT [] +synonym: "jaw skeleton neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "jaw skeleton tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of jaw skeleton" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of jaw skeleton" EXACT [MONDO:patterns/neoplasm] +xref: ICD9:239.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:126634001 {source="MONDO:equivalentTo"} +is_a: MONDO:0006858 ! mouth disorder +is_a: MONDO:0021223 ! digestive system neoplasm +is_a: MONDO:0023369 ! disorder of facial skeleton +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001708 ! jaw skeleton +relationship: disease_has_location UBERON:0001708 ! jaw skeleton +property_value: exactMatch http://identifiers.org/snomedct/126634001 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021581 +name: connective tissue neoplasm +def: "Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue." [MESH:D009372] +synonym: "connective tissue neoplasm" EXACT [MESH:D009372] +synonym: "connective tissue neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "connective tissue neoplasms" RELATED [MESH:D009372] +synonym: "connective tissue tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of connective tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of connective tissues" EXACT [DOID:201] +synonym: "neoplasm, connective tissue" RELATED [MESH:D009372] +synonym: "tumor of connective tissue" EXACT [MONDO:patterns/neoplasm] +synonym: "tumour of connective tissue" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009372 {source="MONDO:equivalentTo"} +xref: SCTID:126598008 {source="MONDO:equivalentTo"} +xref: UMLS:C0027656 {source="MONDO:equivalentTo"} +is_a: MONDO:0003900 {source="MESH:D009372", source="MONDO:Redundant"} ! connective tissue disorder +is_a: MONDO:0005070 {source="MESH:D009372/inferred", source="MONDO:Redundant"} ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002384 ! connective tissue +relationship: disease_has_location UBERON:0002384 ! connective tissue +property_value: exactMatch http://identifiers.org/mesh/D009372 +property_value: exactMatch http://identifiers.org/snomedct/126598008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027656 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021583 +name: melanocytic skin neoplasm +def: "A melanocytic neoplasm that involves the zone of skin." [MONDO:patterns/location] +synonym: "cutaneous melanocytic neoplasm" EXACT [NCIT:C7161] +synonym: "melanocytic neoplasm of skin" EXACT [NCIT:C7161] +synonym: "melanocytic neoplasm of zone of skin" EXACT [MONDO:design_pattern] +synonym: "melanocytic skin neoplasm" EXACT [NCIT:C7161] +synonym: "zone of skin melanocytic neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C7161 {source="MONDO:equivalentTo"} +xref: UMLS:C0349501 {source="MONDO:equivalentTo", source="NCIT:C7161"} +is_a: MONDO:0002531 {source="MONDO:Redundant", source="NCIT:C7161"} ! skin neoplasm +is_a: MONDO:0021143 {source="MONDO:Redundant", source="NCIT:C7161"} ! melanocytic neoplasm +intersection_of: MONDO:0021143 ! melanocytic neoplasm +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0349501 +property_value: exactMatch NCIT:C7161 + +[Term] +id: MONDO:0021588 +name: eyelid sebaceous gland carcinoma +def: "A sebaceous gland carcinoma affecting the eyelid. It arises from the meibomian glands, glands of Zeis, or glands associated with the caruncle. It usually affects elderly women and is characterized by high rate of local recurrence, regional, and distant metastases." [NCIT:C134831] +synonym: "carcinoma of sebaceous gland of eyelid" EXACT [MONDO:patterns/carcinoma] +synonym: "eyelid sebaceous gland carcinoma" EXACT [NCIT:C134831] +synonym: "eyelid SGC" EXACT [NCIT:C134831] +synonym: "sebaceous gland carcinoma of the eyelid" EXACT [NCIT:C134831] +synonym: "sebaceous gland of eyelid carcinoma" EXACT [MONDO:patterns/location] +xref: NCIT:C134831 {source="MONDO:equivalentTo"} +xref: UMLS:C4525405 {source="MONDO:equivalentTo"} +is_a: MONDO:0003876 {source="MONDO:Redundant", source="NCIT:C134831"} ! eyelid carcinoma +is_a: MONDO:0006327 {source="NCIT:C134831"} ! ocular sebaceous carcinoma +is_a: MONDO:0020176 ! palpebral sebaceous gland tumor +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0013231 ! sebaceous gland of eyelid +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4525405 +property_value: exactMatch NCIT:C134831 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0021605 +name: benign eyelid neoplasm +def: "A non-metastasizing neoplasm that arises from the upper or lower eyelid." [NCIT:C4354] +synonym: "benign eyelid neoplasm" EXACT [NCIT:C4354] +synonym: "benign eyelid tumor" EXACT [NCIT:C4354] +synonym: "benign neoplasm of eyelid" EXACT [NCIT:C4354] +synonym: "benign neoplasm of the eyelid" EXACT [NCIT:C4354] +synonym: "benign tumor of eyelid" EXACT [NCIT:C4354] +synonym: "benign tumor of the eyelid" EXACT [NCIT:C4354] +synonym: "eyelid benign neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C4354 {source="MONDO:equivalentTo"} +xref: SCTID:231824001 {source="MONDO:equivalentTo"} +xref: UMLS:C0339107 {source="MONDO:equivalentTo", source="NCIT:C4354"} +is_a: MONDO:0002235 {source="MONDO:Redundant", source="NCIT:C4354"} ! eyelid neoplasm +is_a: MONDO:0021440 ! benign neoplasm of skin +is_a: MONDO:0021454 {source="MONDO:Redundant", source="NCIT:C4354"} ! benign neoplasm of eye +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001711 ! eyelid +property_value: exactMatch http://identifiers.org/snomedct/231824001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339107 +property_value: exactMatch NCIT:C4354 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0021629 +name: uterine ligament neoplasm +def: "A benign, borderline, or malignant neoplasm that affects the uterine ligaments. Representative examples include Wolffian adnexal tumor, papillary cystadenoma, and adenocarcinoma." [NCIT:C40133] +synonym: "neoplasm of the uterine ligament" EXACT [NCIT:C40133] +synonym: "neoplasm of uterine ligament" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the uterine ligament" EXACT [NCIT:C40133] +synonym: "tumor of uterine ligament" EXACT [MONDO:patterns/neoplasm] +synonym: "uterine ligament neoplasm" EXACT [NCIT:C40133] +synonym: "uterine ligament neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "uterine ligament tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C40133] +xref: NCIT:C40133 {source="MONDO:equivalentTo"} +xref: UMLS:C1519870 {source="MONDO:equivalentTo", source="NCIT:C40133"} +is_a: MONDO:0021230 ! uterine cervix neoplasm +is_a: MONDO:0045044 ! ligament disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0036262 ! uterine ligament +relationship: disease_has_location UBERON:0036262 ! uterine ligament +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519870 +property_value: exactMatch NCIT:C40133 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021631 +name: brain astrocytoma +def: "A astrocytoma (excluding glioblastoma) that involves the brain." [MONDO:patterns/location] +synonym: "astrocytoma (excluding glioblastoma) of brain" EXACT [MONDO:design_pattern] +synonym: "brain astrocytoma" EXACT [NCIT:C60780] +synonym: "brain astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +xref: NCIT:C60780 {source="MONDO:equivalentTo"} +xref: SCTID:254938000 {source="MONDO:equivalentTo"} +xref: UMLS:C3695127 {source="MONDO:equivalentTo", source="NCIT:C60780"} +is_a: MONDO:0019781 {source="MONDO:Redundant", source="NCIT:C60780"} ! astrocytoma (excluding glioblastoma) +is_a: MONDO:0021632 {source="NCIT:C60780"} ! primary brain neoplasm +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0000955 ! brain +property_value: exactMatch http://identifiers.org/snomedct/254938000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3695127 +property_value: exactMatch NCIT:C60780 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0021632 +name: primary brain neoplasm +synonym: "primary brain neoplasm" EXACT [NCIT:C4952] +synonym: "primary brain tumor" EXACT [NCIT:C4952] +xref: NCIT:C4952 {source="ONCOTREE:PBT", source="MONDO:equivalentTo"} +xref: ONCOTREE:PBT {source="MONDO:equivalentTo"} +is_a: MONDO:0021211 {source="NCIT:C4952"} ! brain neoplasm +property_value: exactMatch NCIT:C4952 + +[Term] +id: MONDO:0021633 +name: cerebral astrocytoma +def: "An astrocytoma that arises from the cerebral hemispheres." [NCIT:C4951] +synonym: "astrocytoma (excluding glioblastoma) of cerebral hemisphere" EXACT [MONDO:design_pattern] +synonym: "astrocytoma of cerebral hemispheres" EXACT [NCIT:C4951] +synonym: "astrocytoma of cerebrum" EXACT [NCIT:C4951] +synonym: "astrocytoma of the cerebral hemispheres" EXACT [NCIT:C4951] +synonym: "astrocytoma of the cerebrum" EXACT [NCIT:C4951] +synonym: "cerebral astrocytoma" EXACT [NCIT:C4951] +synonym: "cerebral hemisphere astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +synonym: "cerebral hemispheric astrocytoma" EXACT [NCIT:C4951] +xref: NCIT:C4951 {source="MONDO:equivalentTo"} +xref: SCTID:99131000119108 {source="MONDO:equivalentTo"} +is_a: MONDO:0021374 {source="MONDO:Redundant", source="NCIT:C4951", source="NCIT:C4951/inferred"} ! neoplasm of cerebral hemisphere +is_a: MONDO:0021631 {source="MONDO:Redundant", source="NCIT:C4951"} ! brain astrocytoma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0001869 ! cerebral hemisphere +property_value: exactMatch http://identifiers.org/snomedct/99131000119108 +property_value: exactMatch NCIT:C4951 + +[Term] +id: MONDO:0021634 +name: epithelial skin neoplasm +def: "A epithelial neoplasm that involves the zone of skin." [MONDO:patterns/location] +synonym: "epithelial skin neoplasm" EXACT [NCIT:C7342] +synonym: "epithelial skin tumor" EXACT [NCIT:C7342] +synonym: "skin epithelium neoplasm" EXACT [NCIT:C7342] +synonym: "skin epithelium tumor" EXACT [NCIT:C7342] +synonym: "zone of skin epithelial neoplasm" EXACT [MONDO:patterns/location] +xref: NCIT:C7342 {source="MONDO:equivalentTo"} +xref: UMLS:C0345976 {source="NCIT:C7342", source="MONDO:equivalentTo"} +is_a: MONDO:0002531 {source="MONDO:Redundant", source="NCIT:C7342"} ! skin neoplasm +is_a: MONDO:0005626 {source="MONDO:Redundant", source="NCIT:C7342"} ! epithelial neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345976 +property_value: exactMatch NCIT:C7342 + +[Term] +id: MONDO:0021635 +name: neurocristopathy +def: "That disease that arises from defects in the development of tissues containing cells commonly derived from the embryonic neural crest cell lineage." [MONDO:cjm, Wikipedia:Neurocristopathy] +synonym: "disorder of neural crest cell development" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of neural crest development" EXACT [MONDO:cjm] +synonym: "neural crest cell development disease" EXACT [] +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0014032 ! neural crest cell development +relationship: disease_has_basis_in_disruption_of GO:0014032 ! neural crest cell development +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0021636 +name: astrocytic tumor +def: "A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma." [https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23, NCIT:C6958] +comment: This class encompasses astrocytomas proper as well as GBM. See https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23 +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:94"} +synonym: "astrocytic neoplasm" EXACT [NCIT:C6958] +synonym: "astrocytic tumor" EXACT [DOID:3069, NCIT:C6958, Orphanet:94] +synonym: "astrocytoma" NARROW AMBIGUOUS [https://github.com/NCI-Thesaurus/thesaurus-obo-edition/issues/23] +synonym: "astrocytoma of brain" EXACT [DOID:3069] +synonym: "astrocytoma of cerebrum" NARROW [DOID:3069] +synonym: "astrocytoma, no ICD-O subtype" EXACT [DOID:3069] +synonym: "astroglioma" EXACT [DOID:3069, NCIT:C6958] +xref: DOID:3069 {source="MONDO:equivalentTo"} +xref: EFO:0000272 {source="MONDO:equivalentTo"} +xref: MedDRA:10003571 {source="Orphanet:94/e", source="Orphanet:94"} +xref: NCIT:C6958 {source="DOID:3069", source="MONDO:equivalentTo"} +xref: OMIM:137800 {source="MONDO:relatedTo", source="Orphanet:94/ntbt", source="Orphanet:94"} +xref: Orphanet:94 {source="MONDO:equivalentTo"} +is_a: MONDO:0021042 {source="NCIT:C6958"} ! glioma +property_value: closeMatch http://identifiers.org/meddra/10003571 +property_value: exactMatch DOID:3069 +property_value: exactMatch NCIT:C6958 +property_value: exactMatch Orphanet:94 + +[Term] +id: MONDO:0021637 +name: low grade glioma +def: "A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma." [NCIT:C132067] +synonym: "low grade glioma" EXACT [NCIT:C132067] +synonym: "low-grade glioma" EXACT [NCIT:C132067] +xref: NCIT:C132067 {source="MONDO:equivalentTo"} +xref: UMLS:C1997217 {source="MONDO:equivalentTo", source="NCIT:C132067"} +is_a: MONDO:0021042 {source="MONDO:Redundant", source="NCIT:C132067"} ! glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +relationship: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1997217 +property_value: exactMatch NCIT:C132067 + +[Term] +id: MONDO:0021638 +name: low grade astrocytic tumor +def: "A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II)." [NCIT:C116342] +synonym: "low grade astrocytic neoplasm" EXACT [NCIT:C116342] +synonym: "low grade astrocytic tumor" EXACT [NCIT:C116342] +synonym: "low-grade astrocytic neoplasm" EXACT [NCIT:C116342] +synonym: "low-grade astrocytic tumor" EXACT [NCIT:C116342] +xref: NCIT:C116342 {source="MONDO:equivalentTo"} +xref: UMLS:C3898569 {source="NCIT:C116342", source="MONDO:equivalentTo"} +is_a: MONDO:0021636 {source="MONDO:Redundant", source="NCIT:C116342"} ! astrocytic tumor +is_a: MONDO:0021637 {source="MONDO:Redundant", source="NCIT:C116342"} ! low grade glioma +intersection_of: MONDO:0021636 ! astrocytic tumor +intersection_of: has_modifier MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3898569 +property_value: exactMatch NCIT:C116342 + +[Term] +id: MONDO:0021639 +name: grade II glioma +def: "A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma." [NCIT:C132505] +synonym: "grade II glioma" EXACT [NCIT:C132505] +synonym: "WHO grade II glioma" EXACT [NCIT:C132505] +xref: NCIT:C132505 {source="MONDO:equivalentTo"} +xref: UMLS:C4330050 {source="MONDO:equivalentTo"} +is_a: MONDO:0021637 ! low grade glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: has_modifier MONDO:0024492 ! tumor grade 2, general grading system +relationship: has_modifier MONDO:0024492 ! tumor grade 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4330050 +property_value: exactMatch NCIT:C132505 + +[Term] +id: MONDO:0021640 +name: grade III glioma +def: "A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma." [NCIT:C127816] +synonym: "anaplastic glioma" EXACT [NCIT:C127816] +synonym: "WHO grade III glioma" EXACT [NCIT:C127816] +xref: NCIT:C127816 {source="MONDO:equivalentTo"} +xref: UMLS:C4287997 {source="MONDO:equivalentTo"} +is_a: MONDO:0100342 {source="NCIT:C127816"} ! malignant glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: has_modifier MONDO:0024493 ! tumor grade 3, general grading system +relationship: has_modifier MONDO:0024493 ! tumor grade 3, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4287997 +property_value: exactMatch NCIT:C127816 + +[Term] +id: MONDO:0021657 +name: ovarian sex cord-stromal tumor +def: "A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor." [NCIT:C4862] +synonym: "ovarian sex cord tumor with annular tubules" RELATED [GARD:0012285] +synonym: "ovarian Sex cord-stromal neoplasm" EXACT [NCIT:C4862] +synonym: "ovarian Sex cord-stromal tumor" EXACT [NCIT:C4862] +synonym: "ovary sex cord-stromal tumor" EXACT [MONDO:patterns/location] +synonym: "sex cord stromal tumor" RELATED [ONCOTREE:SCST] +synonym: "Sex cord-stromal neoplasm of ovary" EXACT [NCIT:C4862] +synonym: "Sex cord-stromal neoplasm of the ovary" EXACT [NCIT:C4862] +synonym: "Sex cord-stromal tumor of ovary" EXACT [NCIT:C4862] +synonym: "sex cord-stromal tumor of ovary" EXACT [] +synonym: "Sex cord-stromal tumor of the ovary" EXACT [NCIT:C4862] +xref: DOID:0080369 {source="MONDO:equivalentTo"} +xref: EFO:1000430 {source="MONDO:equivalentTo"} +xref: GARD:0012285 {source="MONDO:equivalentTo"} +xref: NCIT:C4862 {source="MONDO:equivalentTo"} +xref: ONCOTREE:SCST {source="MONDO:equivalentTo"} +xref: UMLS:C0600113 {source="MONDO:equivalentTo", source="NCIT:C4862"} +is_a: MONDO:0006055 {source="MONDO:Redundant", source="NCIT:C4862"} ! sex cord-stromal tumor +is_a: MONDO:0021068 {source="MONDO:Redundant", source="NCIT:C4862"} ! ovarian neoplasm +intersection_of: MONDO:0006055 ! sex cord-stromal tumor +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch DOID:0080369 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0600113 +property_value: exactMatch NCIT:C4862 + +[Term] +id: MONDO:0021659 +name: combined carcinoid and adenocarcinoma +def: "A malignant epithelial neoplasm composed of a mixture of neuroendocrine cells with morphologic and immunohistochemical characteristics of carcinoid tumor and malignant glandular cells." [NCIT:C4139] +subset: gard_rare +synonym: "adenocarcinoid neoplasm" EXACT [NCIT:C4139] +synonym: "adenocarcinoid tumor" EXACT [NCIT:C4139] +synonym: "combined carcinoid and adenocarcinoma" EXACT [NCIT:C4139] +synonym: "combined carcinoid neoplasm and adenocarcinoma" EXACT [NCIT:C4139] +synonym: "combined carcinoid tumor and adenocarcinoma" EXACT [NCIT:C4139] +synonym: "composite carcinoid" EXACT [NCIT:C4139] +synonym: "composite carcinoid neoplasm" EXACT [NCIT:C4139] +synonym: "composite carcinoid tumor" EXACT [NCIT:C4139] +synonym: "mixed carcinoid neoplasm" EXACT [NCIT:C4139] +synonym: "mixed carcinoid tumor" EXACT [NCIT:C4139] +xref: GARD:0005741 {source="MONDO:equivalentTo"} +xref: ICDO:8244/3 {source="NCIT:C4139"} +xref: ICDO:8245/3 {source="NCIT:C4139"} +xref: MESH:C538230 {source="MONDO:equivalentTo"} +xref: NCIT:C4139 {source="MONDO:equivalentTo"} +xref: UMLS:C0334302 {source="GARD:0005741", source="MONDO:equivalentTo", source="NCIT:C4139"} +is_a: MONDO:0004993 {source="MESH:C538230/inferred", source="NCIT:C4139"} ! carcinoma +property_value: exactMatch http://identifiers.org/mesh/C538230 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334302 +property_value: exactMatch NCIT:C4139 + +[Term] +id: MONDO:0021661 +name: coronary atherosclerosis +def: "Atherosclerosis of the coronary vasculature." [NCIT:C35505] +synonym: "arteriosclerosis disorder of coronary artery" EXACT [MONDO:design_pattern] +synonym: "atherosclerosis of coronary artery" BROAD [] +synonym: "coronary artery arteriosclerosis (disease)" EXACT [MONDO:patterns/location] +synonym: "coronary artery arteriosclerosis disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "coronary atherosclerosis" EXACT [NCIT:C35505] +xref: ICD9:414.00 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35505 {source="MONDO:equivalentTo"} +xref: SCTID:443502000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005010 {source="MONDO:Redundant", source="https://www.nhlbi.nih.gov/health-topics/coronary-heart-disease"} ! coronary artery disorder +is_a: MONDO:0005311 {source="NCIT:C35505"} ! atherosclerosis +intersection_of: MONDO:0002277 ! arteriosclerosis disorder +intersection_of: disease_has_location UBERON:0001621 ! coronary artery +property_value: exactMatch http://identifiers.org/snomedct/443502000 +property_value: exactMatch NCIT:C35505 + +[Term] +id: MONDO:0021662 +name: bile duct neoplasm +def: "A benign or malignant neoplasm that affects the intrahepatic or extrahepatic bile ducts. Representative examples of benign neoplasms include bile duct adenoma and extrahepatic bile duct lipoma. Representative examples of malignant neoplasms include intrahepatic and extrahepatic cholangiocarcinoma." [NCIT:C2898] +synonym: "bile duct neoplasm" EXACT [NCIT:C2898] +synonym: "bile duct neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "bile duct tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2898] +synonym: "intrahepatic and extrahepatic bile duct neoplasm" EXACT [NCIT:C2898] +synonym: "intrahepatic and extrahepatic bile duct tumor" EXACT [NCIT:C2898] +synonym: "neoplasm of bile duct" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of bile duct" EXACT [MONDO:patterns/neoplasm] +xref: MESH:D001650 {source="MONDO:equivalentTo"} +xref: NCIT:C2898 {source="MONDO:equivalentTo"} +xref: UMLS:C0005396 {source="MONDO:equivalentTo", source="NCIT:C2898"} +is_a: MONDO:0002887 {source="MONDO:Redundant", source="NCIT:C2898"} ! bile duct disorder +is_a: MONDO:0005304 ! biliary tract neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002394 ! bile duct +property_value: exactMatch http://identifiers.org/mesh/D001650 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0005396 +property_value: exactMatch NCIT:C2898 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0021666 +name: ear infection +def: "A viral or bacterial infection that affects the external, middle, or inner ear. It may follow an upper respiratory infection. Signs and symptoms include pain, ear discharge, ear fullness, hearing loss, vertigo, nausea, and vomiting." [NCIT:C27193] +synonym: "Ear infection" EXACT [NCIT:C27193] +synonym: "otitis" EXACT [NCIT:C27193] +xref: MESH:D010031 {source="MONDO:equivalentTo"} +xref: NCIT:C27193 {source="MONDO:equivalentTo"} +xref: UMLS:C0699744 {source="MONDO:equivalentTo", source="NCIT:C27193"} +is_a: MONDO:0005550 ! infectious disease +is_a: MONDO:0021166 {source="MONDO:Entailed", source="NCIT:C27193/inferred"} ! inflammatory disease +is_a: MONDO:0021205 {source="MONDO:Redundant", source="NCIT:C27193/inferred"} ! disorder of ear +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0001690 ! ear +property_value: exactMatch http://identifiers.org/mesh/D010031 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0699744 +property_value: exactMatch NCIT:C27193 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0021667 +name: neuralgia +def: "A pain disorder characterize by pain in the distribution of a nerve or nerves" [Wikipedia:Neuralgia] +synonym: "neuralgia" EXACT [] +synonym: "pain, nerve" RELATED [MESH:D009437] +synonym: "pain, neuropathic" RELATED [MESH:D009437] +synonym: "paroxysmal nerve pain" RELATED [MESH:D009437] +synonym: "paroxysmal nerve pains" RELATED [MESH:D009437] +xref: ICD9:729.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D009437 {source="MONDO:equivalentTo"} +xref: SCTID:16269008 {source="MONDO:equivalentTo"} +is_a: MONDO:0005244 ! peripheral neuropathy +is_a: MONDO:0700057 {source="MONDO:Redundant", source="https://orcid.org/0000-0002-4142-7153"} ! neurological pain disorder +intersection_of: MONDO:0005244 ! peripheral neuropathy +intersection_of: disease_has_major_feature HP:0012531 ! Pain +property_value: exactMatch http://identifiers.org/mesh/D009437 +property_value: exactMatch http://identifiers.org/snomedct/16269008 + +[Term] +id: MONDO:0021669 +name: post-infectious disorder +def: "A disorder that follows infection but is distinct from the infection itself and its usual manifestations." [SCTID:123976001] +synonym: "sequela of infectious disorder" EXACT [https://github.com/monarch-initiative/mondo/pull/3118#issuecomment-871858054, https://orcid.org/0000-0001-5208-3432] +xref: ICD10CM:B90-B94 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:139.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:123976001 {source="MONDO:equivalentTo"} +is_a: MONDO:0100336 ! infectious disease or post-infectious disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_arises_from_feature MONDO:0005550 ! infectious disease +relationship: disease_arises_from_feature MONDO:0005550 ! infectious disease +property_value: exactMatch http://identifiers.org/snomedct/123976001 +property_value: exactMatch https://icd.codes/icd10cm/B90-B94 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml + +[Term] +id: MONDO:0021670 +name: post-infectious syndrome +is_a: MONDO:0002254 ! syndromic disease +is_a: MONDO:0021669 ! post-infectious disorder +intersection_of: MONDO:0002254 ! syndromic disease +intersection_of: disease_arises_from_feature MONDO:0005550 ! infectious disease +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml + +[Term] +id: MONDO:0021673 +name: post-bacterial disorder +is_a: MONDO:0021669 ! post-infectious disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_arises_from_feature MONDO:0005113 ! bacterial infectious disease +relationship: disease_arises_from_feature MONDO:0005113 ! bacterial infectious disease +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml + +[Term] +id: MONDO:0021674 +name: post-viral disorder +def: "A post-infectious disorder that follows viral infection but is distinct from the viral infection itself and its usual manifestations." [https://orcid.org/0000-0001-5208-3432] +synonym: "sequela of viral disease" EXACT [https://orcid.org/0000-0001-5208-3432] +xref: ICD9:139.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:123948009 {source="MONDO:equivalentTo"} +is_a: MONDO:0021669 ! post-infectious disorder +is_a: MONDO:0100321 ! viral disease or post-viral disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_arises_from_feature MONDO:0005108 ! viral infectious disease +relationship: disease_arises_from_feature MONDO:0005108 ! viral infectious disease +property_value: exactMatch http://identifiers.org/snomedct/123948009 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/consequence_of_infectious_disease.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/2950 xsd:string + +[Term] +id: MONDO:0021677 +name: post-infectious neuralgia +synonym: "postinfectious neuralgia" EXACT [] +xref: ICD9:729.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:17111003 {source="MONDO:equivalentTo"} +xref: UMLS:C0032772 {source="MONDO:equivalentTo"} +is_a: MONDO:0021667 ! neuralgia +is_a: MONDO:0021674 ! post-viral disorder +intersection_of: MONDO:0021667 ! neuralgia +intersection_of: disease_arises_from_feature MONDO:0005108 ! viral infectious disease +property_value: exactMatch http://identifiers.org/snomedct/17111003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0032772 + +[Term] +id: MONDO:0021698 +name: alcohol-related disorders +def: "Disorders related to or resulting from abuse or mis-use of alcohol." [MESH:D019973] +synonym: "alcohol related disorders" RELATED [MESH:D019973] +synonym: "alcohol-related disorder" RELATED [MESH:D019973] +synonym: "disorder, alcohol-related" RELATED [MESH:D019973] +synonym: "disorders, alcohol-related" RELATED [MESH:D019973] +xref: MESH:D019973 {source="MONDO:equivalentTo"} +xref: SCTID:29212009 {source="MONDO:equivalentTo"} +is_a: MONDO:0002494 {source="MESH:D019973", source="MONDO:Redundant"} ! substance-related disorder +intersection_of: MONDO:0002494 ! substance-related disorder +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +relationship: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch http://identifiers.org/mesh/D019973 +property_value: exactMatch http://identifiers.org/snomedct/29212009 + +[Term] +id: MONDO:0021699 +name: alcohol-induced disorders +def: "Disorders stemming from the misuse and abuse of alcohol." [MESH:D020751] +synonym: "alcohol induced disorders" RELATED [MESH:D020751] +synonym: "alcohol-induced disorder" RELATED [MESH:D020751] +xref: MESH:D020751 {source="MONDO:equivalentTo"} +xref: SCTID:719848005 {source="MONDO:equivalentTo"} +xref: UMLS:C0236970 {source="MONDO:equivalentTo"} +is_a: MONDO:0021698 {source="MESH:D020751"} ! alcohol-related disorders +property_value: exactMatch http://identifiers.org/mesh/D020751 +property_value: exactMatch http://identifiers.org/snomedct/719848005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0236970 + +[Term] +id: MONDO:0021736 +name: proctosigmoiditis +def: "Inflammation of the sigmoid colon and rectum." [NCIT:C34950] +synonym: "Proctosigmoiditis" RELATED [MESH:D011350, NCIT:C34950] +synonym: "proctosigmoiditis" EXACT [NCIT:C34950] +synonym: "Rectosigmoiditis" RELATED [MESH:D011350] +synonym: "rectosigmoiditis" RELATED [] +xref: ICD9:569.89 +xref: NCIT:C34950 {source="MONDO:equivalentTo", source="UMLS:C0033252"} +xref: SCTID:41364008 {source="MONDO:equivalentTo", source="UMLS:C0033252"} +xref: UMLS:C0033252 {source="MONDO:equivalentTo"} +is_a: MONDO:0024278 {source="NCIT:C34950", source="UMLS:C0033252"} ! proctocolitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001052 ! rectum +intersection_of: disease_has_inflammation_site UBERON:0001159 ! sigmoid colon +relationship: disease_has_inflammation_site UBERON:0001052 ! rectum +relationship: disease_has_inflammation_site UBERON:0001159 ! sigmoid colon +property_value: exactMatch http://identifiers.org/snomedct/41364008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0033252 +property_value: exactMatch NCIT:C34950 + +[Term] +id: MONDO:0021742 +name: puerperal infection +def: "An infection occurring in puerperium, the period of 6-8 weeks after giving birth." [MESH:D011645] +synonym: "Infection, Puerperal" RELATED [MESH:D011645] +synonym: "Infections, Puerperal" RELATED [MESH:D011645] +synonym: "Puerperal Infection" RELATED [MESH:D011645] +synonym: "Puerperal Infections" RELATED [MESH:D011645] +xref: EFO:1001407 {source="MONDO:equivalentTo"} +xref: MESH:D011645 {source="UMLS:C0034041", source="MONDO:equivalentTo"} +xref: UMLS:C0034041 {source="MONDO:equivalentTo"} +is_a: MONDO:0005550 ! infectious disease +is_a: MONDO:0044013 ! puerperal disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0044013 ! puerperal disorder +property_value: exactMatch http://identifiers.org/mesh/D011645 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034041 + +[Term] +id: MONDO:0021746 +name: pyelocystitis +synonym: "Cystopyelitis" RELATED [MESH:D053653] +synonym: "Pyelocystitis" RELATED [MESH:D053653] +xref: EFO:1001835 {source="MONDO:equivalentTo"} +xref: MESH:D053653 {source="UMLS:C0034184", source="MONDO:equivalentTo"} +xref: UMLS:C0034184 {source="MONDO:equivalentTo"} +is_a: MONDO:0006032 {source="MESH:D053653"} ! cystitis +is_a: MONDO:0006938 {source="MESH:D053653"} ! pyelitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001224 ! renal pelvis +intersection_of: disease_has_inflammation_site UBERON:0001255 ! urinary bladder +property_value: exactMatch http://identifiers.org/mesh/D053653 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034184 + +[Term] +id: MONDO:0021925 +name: tracheobronchitis +def: "Inflammation of the tracheobronchial tree." [NCIT:C122784] +synonym: "Tracheobronchitis" RELATED [NCIT:C122784] +synonym: "tracheobronchitis" EXACT [NCIT:C122784] +xref: NCIT:C122784 {source="MONDO:equivalentTo", source="UMLS:C0040586"} +xref: SCTID:13617004 {source="MONDO:equivalentTo", source="UMLS:C0040586"} +xref: UMLS:C0040586 {source="MONDO:equivalentTo"} +is_a: MONDO:0000270 ! lower respiratory tract disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0007196 ! tracheobronchial tree +relationship: disease_has_inflammation_site UBERON:0007196 ! tracheobronchial tree +property_value: exactMatch http://identifiers.org/snomedct/13617004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0040586 +property_value: exactMatch NCIT:C122784 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0021945 +name: hearing disorder +def: "A disorder characterized by the partial or complete loss of the ability to detect sounds due to damage to the ear structures or inability of the brain to properly interpret or process the auditory signals it receives from the anatomic structures of the ear." [NCIT:C3078] +synonym: "auditory alteration" RELATED [] +synonym: "disorder of hearing" RELATED [] +synonym: "hearing disorder" EXACT [NCIT:C3078] +xref: MESH:D006311 {source="MONDO:equivalentTo"} +xref: NCIT:C3078 {source="MONDO:equivalentTo"} +xref: SCTID:128540005 {source="MONDO:equivalentTo"} +xref: UMLS:C0260662 {source="MONDO:equivalentTo", source="NCIT:C3078"} +is_a: MONDO:0002409 ! auditory system disorder +is_a: MONDO:0024417 ! perceptual disorders +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0007605 ! sensory perception of sound +relationship: disease_disrupts GO:0007605 ! sensory perception of sound +property_value: exactMatch http://identifiers.org/mesh/D006311 +property_value: exactMatch http://identifiers.org/snomedct/128540005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0260662 +property_value: exactMatch NCIT:C3078 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0021950 +name: autoimmune oophoritis +def: "Autoimmune oophoritis is a rare cause of primary ovarian insufficiency (POI). It happens when the body's immune system mistakenly attacks the ovaries causing inflammation, atrophy and fibrosis. These changes stop the ovaries from working normally. The main symptoms of autoimmune oophorotis are irregular or absent menstrual period (amenorrhea) and symptoms related to ovarian cysts such as abdominal cramping, bloating, nausea and vomiting. Autoimmune oophoritis may occur as part of autoimmune polyglandular syndrome type I and type II but has also been associated with lupus, pernicious anemia, myasthenia gravis and other autoimmune conditions. The underlying cause of autoimmune oophoritis is unknown. Diagnosis involves a special blood test which looks for anti-steroid or anti-ovarian antibodies, a pelvic ultrasound to look for enlarged cystic ovaries and tests to rule out other possible causes of POI. Management of autoimmune oophoritis involves emotional support, possible estrogen replacement therapy and management of other autoimmune conditions." [GARD:0009461] +subset: gard_rare +xref: GARD:0009461 {source="MONDO:equivalentTo"} +xref: MESH:C538274 {source="MONDO:equivalentTo"} +xref: UMLS:C0878654 {source="GARD:0009461", source="MONDO:equivalentTo"} +is_a: MONDO:0000569 ! autoimmune disorder of endocrine system +is_a: MONDO:0006877 {source="MESH:C538274", source="MONDO:Entailed", source="MONDO:Redundant"} ! oophoritis +intersection_of: MONDO:0006877 ! oophoritis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +relationship: disease_has_feature MONDO:0005387 ! primary ovarian failure +property_value: exactMatch http://identifiers.org/mesh/C538274 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0878654 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9461/autoimmune-oophoritis xsd:anyURI {source="GARD:0009461"} + +[Term] +id: MONDO:0021960 +name: ureteritis +def: "An acute or chronic inflammatory process affecting the ureter." [NCIT:C78666] +synonym: "Inflammation of ureter" RELATED [UMLS:C0041959] +synonym: "Ureteritis" RELATED [NCIT:C78666] +synonym: "ureteritis" EXACT [NCIT:C78666] +xref: NCIT:C78666 {source="MONDO:equivalentTo", source="UMLS:C0041959"} +xref: SCTID:111405003 {source="MONDO:equivalentTo", source="UMLS:C0041959"} +xref: UMLS:C0041959 {source="MONDO:equivalentTo"} +is_a: MONDO:0001926 ! ureteral disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000056 ! ureter +relationship: disease_has_inflammation_site UBERON:0000056 ! ureter +property_value: exactMatch http://identifiers.org/snomedct/111405003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0041959 +property_value: exactMatch NCIT:C78666 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0022103 +name: chronic prostatitis +def: "An infectious or non-infectious chronic inflammatory process that affects the prostate gland." [NCIT:C26930] +synonym: "Chronic Prostatitis" RELATED [NCIT:C26930] +synonym: "Chronic prostatitis" RELATED [UMLS:C0085696] +synonym: "chronic prostatitis" EXACT [NCIT:C26930] +xref: ICD9:601.1 +xref: NCIT:C26930 {source="MONDO:equivalentTo", source="UMLS:C0085696"} +xref: SCTID:19905009 {source="MONDO:equivalentTo", source="UMLS:C0085696"} +xref: UMLS:C0085696 {source="MONDO:equivalentTo"} +is_a: MONDO:0005280 {source="NCIT:C26930", source="UMLS:C0085696"} ! prostatitis +intersection_of: MONDO:0005280 ! prostatitis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/19905009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085696 +property_value: exactMatch NCIT:C26930 + +[Term] +id: MONDO:0022293 +name: vascular disorder of penis +def: "A non-neoplastic or neoplastic disorder that affects the blood vessels of the penis. Representative examples include atherosclerosis, venous leak, and hemangioma." [NCIT:C35218] +synonym: "Penile Vascular Disorder" RELATED [NCIT:C35218] +synonym: "Penile vascular disorder" RELATED [UMLS:C0156307] +synonym: "penile vascular disorder" EXACT [NCIT:C35218] +synonym: "Penis vascular disorder" RELATED [UMLS:C0156307] +synonym: "Vascular disorder of penis" RELATED [UMLS:C0156307] +xref: ICD9:607.82 +xref: MEDGEN:102349 {source="UMLS:C0156307"} +xref: NCIT:C35218 {source="MONDO:equivalentTo", source="UMLS:C0156307"} +xref: SCTID:198029003 {source="MONDO:equivalentTo", source="UMLS:C0156307"} +xref: UMLS:C0156307 {source="MONDO:equivalentTo"} +is_a: MONDO:0002036 {source="NCIT:C35218", source="UMLS:C0156307"} ! penile disorder +is_a: MONDO:0005385 {source="NCIT:C35218", source="UMLS:C0156307"} ! vascular disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0036269 ! penis blood vessel +relationship: disease_has_location UBERON:0036269 ! penis blood vessel +property_value: closeMatch http://identifiers.org/medgen/102349 +property_value: exactMatch http://identifiers.org/snomedct/198029003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0156307 +property_value: exactMatch NCIT:C35218 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0022409 +name: nephropathy-associated ciliopathy +subset: disease_grouping +subset: ordo_group_of_disorders +xref: Orphanet:156162 {source="MONDO:equivalentTo"} +is_a: MONDO:0005240 ! kidney disorder +is_a: MONDO:0005308 {source="Orphanet:156162"} ! ciliopathy +intersection_of: MONDO:0005308 ! ciliopathy +intersection_of: disease_has_location UBERON:0002113 ! kidney +property_value: exactMatch Orphanet:156162 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0022410 +name: retinal ciliopathy +subset: disease_grouping +subset: ordo_group_of_disorders +xref: Orphanet:156165 {source="MONDO:equivalentTo"} +is_a: MONDO:0005283 ! retinal disorder +is_a: MONDO:0005308 {source="Orphanet:156165"} ! ciliopathy +is_a: MONDO:0019117 ! genetic nervous system disorder +intersection_of: MONDO:0005308 ! ciliopathy +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch Orphanet:156165 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0022518 +name: autoimmune inner ear disease +def: "A syndrome characterized by rapidly progressive sensorineural hearing loss (SNHL), that is often bilateral, and is potentially reversible." [https://orcid.org/0000-0001-5208-3432, PMID:26485595] +subset: gard_rare +synonym: "AIED" RELATED ABBREVIATION [GARD:0008582] +xref: GARD:0008582 {source="MONDO:equivalentTo"} +is_a: MONDO:0000587 ! autoimmune disease of ear, nose and throat +is_a: MONDO:0002467 ! inner ear disorder +intersection_of: MONDO:0002467 ! inner ear disorder +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0022519 +name: autoimmune myocarditis +def: "Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended." [GARD:0009519] +subset: gard_rare +xref: GARD:0009519 {source="MONDO:equivalentTo"} +is_a: MONDO:0004496 ! myocarditis +is_a: MONDO:0030701 ! autoimmune cardiomyopathy +intersection_of: MONDO:0004496 ! myocarditis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity + +[Term] +id: MONDO:0022642 +name: childhood carcinoid tumor +def: "A rare carcinoid tumor that occurs during childhood." [NCIT:C118810] +subset: gard_rare +synonym: "carcinoid tumor (disease) of childhood" EXACT [MONDO:patterns/childhood] +synonym: "carcinoid tumor childhood" RELATED [GARD:0009315] +synonym: "childhood carcinoid tumor" EXACT [NCIT:C118810] +synonym: "childhood carcinoid tumor (disease)" EXACT [] +synonym: "pediatric carcinoid tumor (disease)" EXACT [MONDO:patterns/childhood] +xref: GARD:0009315 {source="MONDO:equivalentTo"} +xref: NCIT:C118810 {source="MONDO:equivalentTo"} +xref: UMLS:C3899673 {source="MONDO:equivalentTo", source="NCIT:C118810"} +is_a: MONDO:0005369 {source="MONDO:Redundant", source="NCIT:C118810"} ! carcinoid tumor +is_a: MONDO:0021079 ! childhood neoplasm +intersection_of: MONDO:0005369 ! carcinoid tumor +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3899673 +property_value: exactMatch NCIT:C118810 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9315/carcinoid-tumor-childhood xsd:anyURI {source="GARD:0009315"} + +[Term] +id: MONDO:0022643 +name: carcinoma of the vocal tract +def: "A carcinoma that involves the laryngeal vocal fold." [MONDO:patterns/location] +subset: gard_rare +synonym: "carcinoma of laryngeal vocal fold" EXACT [MONDO:patterns/carcinoma] +synonym: "laryngeal vocal fold carcinoma" EXACT [MONDO:patterns/location] +xref: GARD:0005996 {source="MONDO:equivalentTo"} +is_a: MONDO:0002355 ! glottis carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0003706 ! laryngeal vocal fold +relationship: disease_has_location UBERON:0003706 ! laryngeal vocal fold +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0022672 +name: autosomal dominant cataract +def: "A syndromic cataract that has autosomal dominant inheritance." [https://orcid.org/0000-0001-5208-3432] +subset: gard_rare +synonym: "cataract congenital autosomal dominant" RELATED [GARD:0001143] +xref: GARD:0001143 {source="MONDO:equivalentTo"} +is_a: MONDO:0000426 ! autosomal dominant disease +is_a: MONDO:0020225 ! syndromic cataract +intersection_of: MONDO:0005129 ! cataract +intersection_of: has_modifier HP:0000006 ! Autosomal dominant inheritance +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/1143/cataract-congenital-autosomal-dominant xsd:anyURI {source="GARD:0001143"} + +[Term] +id: MONDO:0022687 +name: cerebellar degeneration +def: "Degeneration of the cerebellum. It may be an inherited condition, a paraneoplastic syndrome, or secondary to autoimmune disorders." [NCIT:C84624] +subset: gard_rare +synonym: "Brain degeneration" EXACT [DOID:1443] +synonym: "cerebellar Degeneration" EXACT [NCIT:C84624] +synonym: "cerebellar degeneration" EXACT [] +synonym: "cerebellum neurodegenerative disease" EXACT [MONDO:patterns/location] +synonym: "cerebral degeneration" RELATED [DOID:1443] +synonym: "neurodegenerative disease of cerebellum" EXACT [MONDO:design_pattern] +xref: DOID:1443 {source="MONDO:equivalentTo"} +xref: GARD:0006019 {source="MONDO:equivalentTo"} +xref: ICD9:331.9 {source="DOID:1443", source="MONDO:directSiblingOf"} +xref: NCIT:C84624 {source="MONDO:equivalentTo"} +xref: SCTID:418143002 {source="DOID:1443", source="MONDO:directSiblingOf"} +xref: SCTID:95646004 {source="MONDO:equivalentTo"} +xref: UMLS:C0154671 {source="DOID:1443", source="MONDO:directSiblingOf"} +xref: UMLS:C0262404 {source="GARD:0006019", source="NCIT:C84624", source="MONDO:equivalentTo"} +is_a: MONDO:0002427 ! cerebellar disorder +is_a: MONDO:0005559 ! neurodegenerative disease +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_has_location UBERON:0002037 ! cerebellum +property_value: exactMatch DOID:1443 +property_value: exactMatch http://identifiers.org/snomedct/95646004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0262404 +property_value: exactMatch NCIT:C84624 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6019/cerebellar-degeneration xsd:anyURI {source="GARD:0006019"} + +[Term] +id: MONDO:0023113 +name: familial colorectal cancer +def: "Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories." [GARD:0008533] +subset: gard_rare +synonym: "colorectal cancer, familial" RELATED [GARD:0008533] +synonym: "hereditary colorectal cancer" EXACT [MONDO:patterns/hereditary] +xref: GARD:0008533 {source="MONDO:equivalentTo"} +xref: UMLS:CN029768 {source="MONDO:equivalentTo"} +is_a: MONDO:0005575 ! colorectal cancer +is_a: MONDO:0017128 ! inherited digestive tract tumor +intersection_of: MONDO:0005575 ! colorectal cancer +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN029768 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/8533/familial-colorectal-cancer xsd:anyURI {source="GARD:0008533"} + +[Term] +id: MONDO:0023122 +name: familial prostate carcinoma +def: "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." [NCIT:C103817] +comment: Editor note: check OMIM +subset: gard_rare +synonym: "familial prostate cancer" EXACT [GTR:AN0101368] +synonym: "hereditary prostate cancer" EXACT [GTR:AN0101369, MONDO:patterns/hereditary, NCIT:C103817] +synonym: "hereditary prostate carcinoma" EXACT [NCIT:C103817] +synonym: "prostate cancer, autosomal dominant, somatic mutation" EXACT [OMIM:176807, OMIM:genemap2] +synonym: "prostate cancer, familial" RELATED [GARD:0004520] +synonym: "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:176807, OMIM:genemap2] +synonym: "prostate cancer, hereditary" RELATED [GARD:0004520] +synonym: "prostate cancer, somatic" EXACT [OMIM:176807, OMIM:genemap2] +synonym: "prostate cancer, susceptibility to, autosomal dominant, somatic mutation" EXACT [OMIM:176807, OMIM:genemap2] +xref: GARD:0004520 {source="MONDO:equivalentTo"} +xref: GTR:AN0101368 {source="UMLS:CN036094"} +xref: GTR:AN0101369 {source="UMLS:CN036094"} +xref: NCIT:C103817 {source="MONDO:equivalentTo"} +xref: OMIM:176807 {source="Orphanet:1331/ntbt", source="Orphanet:1331", source="MONDO:equivalentTo", source="DOID:10283"} +xref: Orphanet:1331 {source="GARD:0004520", source="MONDO:equivalentTo", source="OMIM:176807", source="DOID:10283"} +xref: SCTID:715412008 {source="MONDO:equivalentTo"} +xref: UMLS:C2931456 {source="GARD:0004520", source="MONDO:equivalentTo"} +xref: UMLS:CN036094 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005159 {source="NCIT:C103817"} ! prostate carcinoma +intersection_of: MONDO:0005159 ! prostate carcinoma +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/715412008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2931456 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN036094 +property_value: exactMatch https://omim.org/entry/176807 +property_value: exactMatch NCIT:C103817 +property_value: exactMatch Orphanet:1331 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/4521 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/4520/familial-prostate-cancer xsd:anyURI {source="GARD:0004520"} + +[Term] +id: MONDO:0023161 +name: viral myocarditis +def: "Myocarditis that is caused by an infection with a viral agent." [NCIT:C128381] +synonym: "Viral Myocarditis" RELATED [NCIT:C128381] +synonym: "Viral myocarditis" RELATED [UMLS:C0276138] +synonym: "viral myocarditis" EXACT [NCIT:C128381] +xref: NCIT:C128381 {source="MONDO:equivalentTo", source="UMLS:C0276138"} +xref: SCTID:89141000 {source="MONDO:equivalentTo", source="UMLS:C0276138"} +xref: UMLS:C0276138 {source="MONDO:equivalentTo"} +is_a: MONDO:0004496 {source="NCIT:C128381", source="UMLS:C0276138"} ! myocarditis +is_a: MONDO:0100329 ! primary viral infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0002349 ! myocardium +intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +property_value: exactMatch http://identifiers.org/snomedct/89141000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0276138 +property_value: exactMatch NCIT:C128381 + +[Term] +id: MONDO:0023164 +name: viral pericarditis +def: "Pericarditis that is caused by an infection with a viral agent." [NCIT:C128405] +synonym: "Viral Pericarditis" RELATED [NCIT:C128405] +synonym: "Viral pericarditis" RELATED [UMLS:C0276139] +synonym: "viral pericarditis" EXACT [NCIT:C128405] +xref: NCIT:C128405 {source="MONDO:equivalentTo", source="UMLS:C0276139"} +xref: SCTID:70189005 {source="MONDO:equivalentTo", source="UMLS:C0276139"} +xref: UMLS:C0276139 {source="MONDO:equivalentTo"} +is_a: MONDO:0005904 {source="NCIT:C128405"} ! pericarditis +is_a: MONDO:0100329 ! primary viral infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0002407 ! pericardium +intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +property_value: exactMatch http://identifiers.org/snomedct/70189005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0276139 +property_value: exactMatch NCIT:C128405 + +[Term] +id: MONDO:0023283 +name: ovarian granulosa cell tumor +def: "A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis." [NCIT:C6261] +synonym: "adult granulosa cell tumor of the ovary" RELATED [MESH:C537296] +synonym: "GCT of the ovary" RELATED [MESH:C537296] +synonym: "granulosa cell neoplasm of ovary" EXACT [NCIT:C6261] +synonym: "granulosa cell neoplasm of the ovary" EXACT [NCIT:C6261] +synonym: "granulosa cell tumor of ovary" EXACT [NCIT:C6261] +synonym: "granulosa cell tumor of the ovary" EXACT [NCIT:C6261] +synonym: "granulosa theca cell tumor" RELATED [MESH:C537296] +synonym: "granulosa theca cell tumor of the ovary" RELATED [MESH:C537296] +synonym: "ovarian granulosa cell neoplasm" EXACT [NCIT:C6261] +synonym: "ovarian granulosa cell tumor" EXACT [NCIT:C6261] +synonym: "ovary granulosa cell tumor" EXACT [MONDO:patterns/location] +xref: EFO:1000421 {source="MONDO:equivalentTo"} +xref: MESH:C537296 {source="MONDO:equivalentTo"} +xref: NCIT:C6261 {source="MONDO:equivalentTo"} +xref: SCTID:254863004 {source="MONDO:equivalentTo"} +xref: UMLS:C1370419 {source="MONDO:equivalentTo", source="NCIT:C6261"} +is_a: MONDO:0006036 {source="MESH:C537296", source="MONDO:Redundant", source="NCIT:C6261"} ! granulosa cell tumor +is_a: MONDO:0021657 {source="MONDO:Redundant", source="NCIT:C6261/inferred"} ! ovarian sex cord-stromal tumor +intersection_of: MONDO:0006036 ! granulosa cell tumor +intersection_of: disease_has_location UBERON:0000992 ! ovary +property_value: exactMatch http://identifiers.org/mesh/C537296 +property_value: exactMatch http://identifiers.org/snomedct/254863004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1370419 +property_value: exactMatch NCIT:C6261 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0023369 +name: disorder of facial skeleton +def: "A disease that involves the facial skeleton." [MONDO:patterns/location] +synonym: "disease of facial skeleton" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of facial skeleton" EXACT [] +synonym: "disorder of facial skeleton" EXACT [MONDO:patterns/location_top] +synonym: "facial skeleton disease" EXACT [MONDO:patterns/location] +synonym: "facial skeleton disease or disorder" EXACT [MONDO:patterns/location] +synonym: "maxillo-facial disease" EXACT [MONDO:cjm] +synonym: "maxillofacial anomaly" EXACT [MONDO:cjm] +is_a: MONDO:0024654 ! skull disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0011156 ! facial skeleton +relationship: disease_has_location UBERON:0011156 ! facial skeleton +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0023370 +name: neoplastic disease or syndrome +def: "Either an isolated neoplasm or a syndrome with neoplasm as a major feature." [MONDO:cjm] +synonym: "neoplastic disease" RELATED [] +synonym: "neoplastic disorder" RELATED [] +is_a: MONDO:0045024 {source="MONDO:Redundant"} ! cancer or benign tumor +union_of: MONDO:0005070 ! neoplasm +union_of: MONDO:0021058 ! neoplastic syndrome + +[Term] +id: MONDO:0023557 +name: infective vaginitis +def: "An infectious process affecting the vagina. Symptoms include pain and purulent discharge." [NCIT:C84353] +synonym: "Infective vaginitis" RELATED [UMLS:C0404521] +synonym: "PV - Vaginal infection" RELATED [UMLS:C0404521] +synonym: "Vaginal Infection" RELATED [NCIT:C84353] +synonym: "Vaginal infection" RELATED [UMLS:C0404521] +synonym: "vaginal infection" EXACT [NCIT:C84353] +xref: NCIT:C84353 {source="UMLS:C0404521", source="MONDO:equivalentTo"} +xref: SCTID:237091009 {source="UMLS:C0404521", source="MONDO:equivalentTo"} +xref: UMLS:C0404521 {source="MONDO:equivalentTo"} +is_a: MONDO:0002234 {source="NCIT:C84353", source="UMLS:C0404521"} ! vaginitis +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0000996 ! vagina +property_value: exactMatch http://identifiers.org/snomedct/237091009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0404521 +property_value: exactMatch NCIT:C84353 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0023603 +name: hereditary disorder of connective tissue +def: "An inherited genetic disorder that affects the connective tissues. Representative examples include Ehlers-Danlos syndrome and Marfan syndrome." [NCIT:C97075] +synonym: "connective tissue hereditary disorder" EXACT [NCIT:C97075, UMLS:C0410787] +synonym: "Hereditary Connective Tissue Disorder" RELATED [NCIT:C97075] +synonym: "hereditary connective tissue disorder" EXACT [NCIT:C97075] +synonym: "Inherited disorder of connective tissue" RELATED [UMLS:C0410787] +synonym: "inherited disorder of connective tissue" RELATED [] +synonym: "Mendelian connective tissue disorder" EXACT [https://orcid.org/0000-0002-0736-9199] +xref: NCIT:C97075 {source="MONDO:equivalentTo", source="UMLS:C0410787"} +xref: SCTID:363045008 {source="MONDO:equivalentTo", source="UMLS:C0410787"} +xref: UMLS:C0410787 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0003900 {source="NCIT:C97075", source="UMLS:C0410787"} ! connective tissue disorder +intersection_of: MONDO:0003900 ! connective tissue disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/363045008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0410787 +property_value: exactMatch NCIT:C97075 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3606 xsd:string + +[Term] +id: MONDO:0023644 +name: lip and oral cavity carcinoma +def: "A carcinoma arising in the lip or oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. Lip carcinomas are usually basal cell or squamous cell carcinomas." [NCIT:C9315] +subset: gard_rare +synonym: "lip and oral cavity cancer" EXACT [NCIT:C9315] +synonym: "lip and oral cavity carcinoma" EXACT [NCIT:C9315] +synonym: "oral cancer" EXACT [NCIT:C9315] +synonym: "oral carcinoma" EXACT [NCIT:C9315] +xref: GARD:0009342 {source="MONDO:equivalentTo"} +xref: GARD:0009360 {source="MONDO:equivalentTo"} +xref: NCIT:C9315 {source="MONDO:equivalentTo"} +xref: UMLS:C0220641 {source="MONDO:equivalentTo", source="NCIT:C9315", source="GARD:0009342"} +is_a: MONDO:0002038 {source="NCIT:C9315"} ! head and neck carcinoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0220641 +property_value: exactMatch NCIT:C9315 +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/9342/lip-and-oral-cavity-cancer xsd:anyURI {source="GARD:0009342"} + +[Term] +id: MONDO:0023682 +name: tympanic paraganglioma +def: "A benign or malignant middle ear paraganglioma arising from paraganglia around the tympanum. Signs and symptoms include a mass behind the tympanum, tinnitus, and conductive hearing loss." [NCIT:C8428] +synonym: "Glomus tympanicum paraganglioma" RELATED [GTR:AN0102048] +synonym: "Glomus Tympanicum Tumor" RELATED [MESH:D043604] +synonym: "Glomus tympanicum tumor" RELATED [GTR:AN0102047] +synonym: "Glomus Tympanicum Tumors" RELATED [MESH:D043604] +synonym: "Tumor, Glomus Tympanicum" RELATED [MESH:D043604] +synonym: "Tumors, Glomus Tympanicum" RELATED [MESH:D043604] +synonym: "Tympanic Paraganglioma" RELATED [NCIT:C8428] +synonym: "Tympanic paraganglioma" RELATED [UMLS:C0474820] +synonym: "tympanic paraganglioma" EXACT [NCIT:C8428] +xref: GTR:AN0102047 {source="UMLS:C0474820"} +xref: GTR:AN0102048 {source="UMLS:C0474820"} +xref: MESH:D043604 {source="MONDO:equivalentTo", source="UMLS:C0474820"} +xref: NCIT:C8428 {source="MONDO:equivalentTo", source="UMLS:C0474820"} +xref: SCTID:253031000 {source="MONDO:equivalentTo", source="UMLS:C0474820"} +xref: UMLS:C0474820 {source="MONDO:equivalentTo"} +is_a: MONDO:0006239 ! head and neck paraganglioma +is_a: MONDO:0015071 ! middle ear neuroendocrine tumor +is_a: MONDO:0018751 ! genetic otorhinolaryngologic disease +is_a: MONDO:0037940 ! inherited auditory system disease +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: disease_has_location UBERON:0004114 ! tympanic cavity +relationship: disease_has_location UBERON:0004114 ! tympanic cavity +property_value: exactMatch http://identifiers.org/mesh/D043604 +property_value: exactMatch http://identifiers.org/snomedct/253031000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0474820 +property_value: exactMatch NCIT:C8428 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0023865 +name: corneal infection +def: "A viral or bacterial infectious process affecting the cornea. Symptoms include pain and redness in the eye, photophobia and eye watering." [NCIT:C83813] +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "corneal infection" EXACT [NCIT:C83813, UMLS:C0729777] +synonym: "infection of cornea" EXACT [UMLS:C0729777] +synonym: "infective keratitis" EXACT [MONDO:cjm] +synonym: "keratitis caused by infection" EXACT [MONDO:cjm] +xref: NCIT:C83813 {source="UMLS:C0729777", source="MONDO:equivalentTo"} +xref: Orphanet:519278 {source="MONDO:equivalentTo"} +xref: SCTID:312428002 {source="UMLS:C0729777", source="MONDO:equivalentTo"} +xref: UMLS:C0729777 {source="MONDO:equivalentTo"} +is_a: MONDO:0003085 {source="NCIT:C83813"} ! keratitis +is_a: MONDO:0016047 ! endophthalmitis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0000964 ! cornea +property_value: exactMatch http://identifiers.org/snomedct/312428002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0729777 +property_value: exactMatch NCIT:C83813 +property_value: exactMatch Orphanet:519278 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024237 +name: inherited neurodegenerative disorder +def: "An inherited disorder characterized by progressive degeneration and atrophy of the nervous system." [NCIT:C97073] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:183500"} +synonym: "genetic neurodegenerative disease" EXACT [MONDO:0015952, MONDO:patterns/genetic] +synonym: "hereditary neurodegenerative disease" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary neurodegenerative disorder" EXACT [NCIT:C97073] +xref: MESH:D020271 {source="MONDO:equivalentTo"} +xref: NCIT:C97073 {source="MONDO:equivalentTo"} +xref: Orphanet:183500 {source="MONDO:equivalentTo"} +xref: UMLS:C3273225 {source="NCIT:C97073", source="MONDO:equivalentTo"} +xref: UMLS:CN200549 {source="MONDO:equivalentTo"} +is_a: MONDO:0005559 {source="MESH:D020271", source="MONDO:Redundant", source="NCIT:C97073"} ! neurodegenerative disease +is_a: MONDO:0019117 {source="MONDO:Redundant", source="Orphanet:183500"} ! genetic nervous system disorder +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/D020271 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3273225 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN200549 +property_value: exactMatch NCIT:C97073 +property_value: exactMatch Orphanet:183500 +property_value: excluded_subClassOf MONDO:0002320 {source="NCIT:C97073"} + +[Term] +id: MONDO:0024238 +name: cerebral degeneration +def: "A neurodegenerative disease that involves the telencephalon." [MONDO:patterns/location] +synonym: "cerebral degeneration" EXACT [] +synonym: "neurodegenerative disease of telencephalon" EXACT [MONDO:design_pattern] +synonym: "telencephalon neurodegenerative disease" EXACT [MONDO:patterns/location] +xref: ICD9:331.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:418143002 {source="MONDO:equivalentTo"} +xref: UMLS:C0154671 {source="MONDO:equivalentTo"} +is_a: MONDO:0005559 ! neurodegenerative disease +is_a: MONDO:0005560 {source="MONDO:Redundant"} ! brain disorder +intersection_of: MONDO:0005559 ! neurodegenerative disease +intersection_of: disease_has_location UBERON:0001893 ! telencephalon +relationship: disease_has_location UBERON:0001893 ! telencephalon +property_value: exactMatch http://identifiers.org/snomedct/418143002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0154671 + +[Term] +id: MONDO:0024239 +name: congenital anomaly of cardiovascular system +def: "A disease that has its basis in the disruption of cardiovascular system development." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "cardiovascular system development disease" EXACT [MONDO:design_pattern] +synonym: "congenital Abnormality of the circulatory system" EXACT [NCIT:C35729] +synonym: "congenital anomaly of cardiovascular system" EXACT [] +synonym: "congenital cardiovascular Abnormality" EXACT [NCIT:C35729] +synonym: "congenital cardiovascular anomaly" EXACT [NCIT:C35729] +synonym: "congenital cardiovascular disorder" RELATED [] +synonym: "disorder of cardiovascular system development" EXACT [MONDO:patterns/basis_in_disruption_of_process] +xref: ICD9:747.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:747.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: NCIT:C35729 {source="MONDO:equivalentTo"} +xref: SCTID:9904008 {source="MONDO:equivalentTo"} +is_a: MONDO:0004995 {source="NCIT:C35729/inferred"} ! cardiovascular disorder +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0072359 ! circulatory system development +relationship: disease_has_basis_in_disruption_of GO:0072359 ! circulatory system development +property_value: exactMatch http://identifiers.org/snomedct/9904008 +property_value: exactMatch NCIT:C35729 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0024240 +name: eccrine carcinoma +def: "An adenocarcinoma with eccrine differentiation arising from the sweat glands. It includes the following subtypes: ductal eccrine adenocarcinoma, papillary eccrine carcinoma, and eccrine porocarcinoma." [NCIT:C27255] +synonym: "carcinoma of eccrine sweat gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma, eccrine gland, malignant" EXACT [NCIT:C27255] +synonym: "eccrine adenocarcinoma" EXACT [DOID:4920, NCIT:C27255] +synonym: "eccrine adenocarcinoma (morphologic abnormality)" EXACT [DOID:4920] +synonym: "eccrine carcinoma" EXACT [NCIT:C27255] +synonym: "eccrine carcinoma of skin" EXACT [] +synonym: "eccrine sweat gland adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "eccrine sweat gland carcinoma" EXACT [MONDO:patterns/location] +xref: DOID:4920 {source="MONDO:equivalentTo"} +xref: ICDO:8413/3 {source="NCIT:C27255"} +xref: NCIT:C27255 {source="MONDO:equivalentTo"} +xref: SCTID:400173004 {source="MONDO:equivalentTo"} +xref: UMLS:C1266066 {source="MONDO:equivalentTo", source="DOID:4920"} +xref: UMLS:C1302864 {source="NCIT:C27255", source="MONDO:equivalentTo"} +xref: UMLS:C1707878 {source="MONDO:equivalentObsolete"} +is_a: MONDO:0005506 {source="DOID:4920", source="MONDO:Redundant", source="NCIT:C27255"} ! eccrine sweat gland cancer +is_a: MONDO:0005524 {source="MONDO:Redundant", source="NCIT:C27255"} ! sweat gland carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000423 ! eccrine sweat gland +property_value: exactMatch DOID:4920 +property_value: exactMatch http://identifiers.org/snomedct/400173004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1266066 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1302864 +property_value: exactMatch NCIT:C27255 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0024247 +name: benign eccrine neoplasm +def: "A non-metastasizing eccrine appendage sweat gland neoplasm. Representative examples include hidrocystoma, syringoma, and syringofibroadenoma." [NCIT:C6797] +synonym: "benign eccrine neoplasm" EXACT [NCIT:C6797] +synonym: "benign eccrine neoplasm of skin" EXACT [NCIT:C6797] +synonym: "benign eccrine neoplasm of the skin" EXACT [NCIT:C6797] +synonym: "benign eccrine skin neoplasm" EXACT [NCIT:C6797] +synonym: "benign eccrine skin tumor" EXACT [NCIT:C6797] +synonym: "benign eccrine sweat gland neoplasm" EXACT [] +synonym: "benign eccrine tumor" EXACT [NCIT:C6797] +synonym: "benign eccrine tumor of skin" EXACT [NCIT:C6797] +synonym: "benign eccrine tumor of the skin" EXACT [NCIT:C6797] +synonym: "benign skin tumor with eccrine differentiation" EXACT [] +synonym: "eccrine sweat gland neoplasm, benign" EXACT [MONDO:patterns/benign] +xref: NCIT:C6797 {source="MONDO:equivalentTo"} +xref: SCTID:254715009 {source="MONDO:equivalentTo"} +xref: UMLS:C1332493 {source="MONDO:equivalentTo"} +is_a: MONDO:0002090 {source="MONDO:Redundant", source="NCIT:C6797"} ! eccrine sweat gland neoplasm +is_a: MONDO:0021489 {source="MONDO:Redundant", source="NCIT:C6797"} ! benign neoplasm of sweat gland +intersection_of: MONDO:0002090 ! eccrine sweat gland neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://identifiers.org/snomedct/254715009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332493 +property_value: exactMatch NCIT:C6797 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0024255 +name: genetic skin disease +def: "An instance of skin disease that is caused by a modification of the individual's genome." [MONDO:patterns/genetic] +comment: Reason: out of scope. MONDO:excludeGeneticFormOfDisease and MONDO:excludeGroupingClass. Term to consider: MONDO:0005093 skin disorder +subset: obsoletion_candidate +synonym: "disease, genetic skin" RELATED [MESH:D012873] +synonym: "diseases, genetic skin" RELATED [MESH:D012873] +synonym: "genetic skin disease" EXACT [MESH:D012873, MONDO:patterns/genetic] +synonym: "genetic skin diseases" RELATED [MESH:D012873] +synonym: "genodermatosis" EXACT [] +synonym: "skin disease, genetic" RELATED [MESH:D012873] +xref: MESH:D012873 {source="MONDO:equivalentTo"} +xref: SCTID:239001006 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 {source="MESH:D012873"} ! Mendelian disease +is_a: MONDO:0005093 {source="MESH:D012873", source="MONDO:Redundant"} ! skin disorder +intersection_of: MONDO:0005093 ! skin disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/mesh/D012873 +property_value: exactMatch http://identifiers.org/snomedct/239001006 +property_value: IAO:0006012 "2022-09-01" xsd:string +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/5114 + +[Term] +id: MONDO:0024257 +name: hereditary motor neuron disease +def: "An instance of motor neuron disease that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "genetic anterior horn cell disease" EXACT [Orphanet:98505] +synonym: "genetic motor neuron disease" EXACT [MONDO:patterns/hereditary] +synonym: "hereditary motor neuron disease" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:98505 {source="MONDO:equivalentTo"} +xref: SCTID:49793008 {source="MONDO:equivalentTo"} +xref: UMLS:CN207018 {source="MONDO:equivalentTo"} +is_a: MONDO:0020128 {source="MONDO:Redundant", source="Orphanet:98505"} ! motor neuron disorder +is_a: MONDO:0024237 ! inherited neurodegenerative disorder +intersection_of: MONDO:0020128 ! motor neuron disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/49793008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN207018 +property_value: exactMatch Orphanet:98505 + +[Term] +id: MONDO:0024276 +name: glandular cell neoplasm +synonym: "glandular cell epithelial neoplasm" EXACT [NCIT:C7132] +synonym: "glandular cell epithelium neoplasm" EXACT [NCIT:C7132] +synonym: "glandular cell neoplasm" EXACT [NCIT:C7132] +synonym: "glandular cell tumor" EXACT [MONDO:cjm] +xref: HP:0031493 {source="MONDO:otherHierarchy"} +xref: NCIT:C7132 {source="MONDO:equivalentTo"} +xref: UMLS:C1333820 {source="NCIT:C7132", source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="NCIT:C7132"} ! epithelial neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333820 +property_value: exactMatch NCIT:C7132 + +[Term] +id: MONDO:0024278 +name: proctocolitis +def: "Inflammation of the rectum and colon." [NCIT:C77952] +synonym: "colorectum inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of colorectum" EXACT [] +synonym: "proctocolitis" EXACT [NCIT:C77952] +xref: NCIT:C77952 {source="MONDO:equivalentTo"} +xref: SCTID:418130002 {source="MONDO:equivalentTo"} +xref: UMLS:C0033247 {source="MONDO:equivalentTo", source="NCIT:C77952"} +is_a: MONDO:0005292 {source="MONDO:Inferred"} ! colitis +is_a: MONDO:0005538 {source="MONDO:Inferred"} ! proctitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0012652 ! colorectum +relationship: disease_has_inflammation_site UBERON:0012652 ! colorectum +property_value: exactMatch http://identifiers.org/snomedct/418130002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0033247 +property_value: exactMatch NCIT:C77952 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0024279 +name: chronic endometritis +def: "A non-granulomatous or granulomatous chronic inflammation of the endometrium. Causes include sexually transmitted pathogens and gynecological procedures. Patients may present with irregular bleeding." [NCIT:C102820] +synonym: "chronic endometritis" EXACT [NCIT:C102820] +synonym: "endometritis, chronic" EXACT [MONDO:patterns/chronic] +xref: NCIT:C102820 {source="MONDO:equivalentTo"} +xref: SCTID:63922003 {source="MONDO:equivalentTo"} +xref: UMLS:C0238104 {source="MONDO:equivalentTo", source="NCIT:C102820"} +is_a: MONDO:0000918 {source="MONDO:Redundant", source="NCIT:C102820"} ! endometritis +intersection_of: MONDO:0000918 ! endometritis +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/63922003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0238104 +property_value: exactMatch NCIT:C102820 + +[Term] +id: MONDO:0024286 +name: benign blood vessel neoplasm +def: "A benign neoplasm arising from arteries or veins." [NCIT:C8537] +synonym: "benign blood vessel neoplasm" EXACT [NCIT:C8537] +synonym: "benign blood vessel tumor" EXACT [NCIT:C8537] +xref: NCIT:C8537 {source="MONDO:equivalentTo"} +xref: UMLS:C0685121 {source="MONDO:equivalentTo", source="NCIT:C8537"} +is_a: MONDO:0000629 ! cardiovascular organ benign neoplasm +is_a: MONDO:0021080 {source="MONDO:Redundant", source="NCIT:C8537"} ! blood vessel neoplasm +intersection_of: MONDO:0021080 ! blood vessel neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0685121 +property_value: exactMatch NCIT:C8537 + +[Term] +id: MONDO:0024294 +name: skin disorder caused by infection +def: "Skin diseases caused by bacteria, fungi, parasites, or viruses." [MESH:D012874] +synonym: "disease, infectious skin" RELATED [MESH:D012874] +synonym: "diseases, infectious skin" RELATED [MESH:D012874] +synonym: "infectious skin disease" RELATED [MESH:D012874] +synonym: "infectious skin diseases" RELATED [MESH:D012874] +synonym: "skin disease, infectious" RELATED [MESH:D012874] +xref: MESH:D012874 {source="MONDO:equivalentTo"} +is_a: MONDO:0005093 {source="MESH:D012874", source="MONDO:Entailed", source="MONDO:Redundant"} ! skin disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0000014 ! zone of skin +property_value: exactMatch http://identifiers.org/mesh/D012874 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024295 +name: skin disease caused by bacterial infection +def: "Skin diseases caused by bacteria." [MESH:D017192] +synonym: "Bacteria caused skin disease caused by infection" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Bacteria skin disease caused by infection" EXACT [] +synonym: "bacterial skin disease" RELATED [MESH:D017192] +synonym: "bacterial skin diseases" RELATED [MESH:D017192] +synonym: "disease, bacterial skin" RELATED [MESH:D017192] +synonym: "diseases, bacterial skin" RELATED [MESH:D017192] +synonym: "skin disease, bacterial" RELATED [MESH:D017192] +xref: MESH:D017192 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 {source="MESH:D017192", source="MONDO:Redundant"} ! bacterial infectious disease +is_a: MONDO:0024294 {source="MESH:D017192", source="MONDO:Entailed", source="MONDO:Redundant"} ! skin disorder caused by infection +intersection_of: MONDO:0024294 ! skin disorder caused by infection +intersection_of: disease_has_infectious_agent NCBITaxon:2 ! Bacteria +property_value: exactMatch http://identifiers.org/mesh/D017192 + +[Term] +id: MONDO:0024296 +name: vascular neoplasm +def: "A benign, intermediate, or malignant neoplasm arising from vascular tissue including arteries, veins, venous sinuses, lymphatic vessels, arterioles and capillaries. It may occur in essentially any body location and is characterized by the presence of vascular channel formation and endothelial cells." [NCIT:C7388] +synonym: "neoplasm of vascular system" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of vascular tissue" EXACT [NCIT:C7388] +synonym: "neoplasms, vascular" EXACT [NCIT:C7388] +synonym: "tumor of vascular system" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of vascular tissue" EXACT [NCIT:C7388] +synonym: "tumors, vascular" EXACT [NCIT:C7388] +synonym: "vascular neoplasm" EXACT [NCIT:C7388] +synonym: "vascular neoplasms" EXACT [NCIT:C7388] +synonym: "vascular system neoplasm" EXACT [] +synonym: "vascular system neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "vascular system tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "vascular tissue neoplasm" EXACT [NCIT:C7388] +synonym: "vascular tissue tumor" EXACT [NCIT:C7388] +synonym: "vascular tumor" EXACT [NCIT:C7388] +synonym: "vascular tumors" EXACT [NCIT:C7388] +xref: NCIT:C7388 {source="MONDO:equivalentTo"} +is_a: MONDO:0024757 ! cardiovascular neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0007798 ! vascular system +relationship: disease_has_location UBERON:0007798 ! vascular system +property_value: exactMatch NCIT:C7388 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024298 +name: vitamin deficiency disorder +def: "A disorder that is caused by the deficiency of a vitamin. The deficiency may result from either suboptimal vitamin intake or conditions that prevent the vitamin's use or absorption in the body. Representative examples include beriberi caused by thiamine deficiency, scurvy caused by vitamin C deficiency, and rickets caused by vitamin D deficiency." [NCIT:C35772] +synonym: "Avitaminoses" RELATED [MESH:D001361] +synonym: "avitaminosis" EXACT [NCIT:C35772] +synonym: "deficiencies, vitamin" RELATED [MESH:D001361] +synonym: "deficiency, vitamin" RELATED [MESH:D001361] +synonym: "vitamin deficiencies" RELATED [MESH:D001361] +synonym: "vitamin deficiency" EXACT [MESH:D001361, NCIT:C35772] +synonym: "vitamin deficiency disorder" EXACT [NCIT:C35772] +xref: EFO:0005878 {source="MONDO:equivalentTo"} +xref: ICD9:269.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:269.2 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D001361 {source="MONDO:equivalentTo"} +xref: NCIT:C35772 {source="MONDO:equivalentTo"} +xref: SCTID:85670002 {source="MONDO:equivalentTo"} +xref: UMLS:C0376286 {source="MONDO:equivalentTo"} +xref: UMLS:C1510471 {source="MONDO:equivalentTo", source="NCIT:C35772"} +is_a: MONDO:0006873 {source="MESH:D001361", source="MONDO:cjm"} ! nutritional deficiency disease +property_value: exactMatch http://identifiers.org/mesh/D001361 +property_value: exactMatch http://identifiers.org/snomedct/85670002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0376286 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1510471 +property_value: exactMatch NCIT:C35772 + +[Term] +id: MONDO:0024301 +name: acquired mineral metabolism disease +def: "An instance of mineral metabolism disease that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +synonym: "acquired mineral metabolism disease" EXACT [MONDO:patterns/acquired] +synonym: "mineral metabolism disease" RELATED [DOID:0050032] +xref: DOID:0050032 {source="MONDO:equivalentTo"} +is_a: MONDO:0000226 ! mineral metabolism disease +is_a: MONDO:0006504 {source="DOID:0050032", source="MONDO:Entailed", source="MONDO:Redundant"} ! acquired metabolic disease +intersection_of: MONDO:0000226 ! mineral metabolism disease +intersection_of: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch DOID:0050032 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/acquired.yaml + +[Term] +id: MONDO:0024311 +name: cancer affecting bone of limb skeleton +def: "A cancer that involves the limb bone." [MONDO:patterns/location] +synonym: "cancer of limb bone" EXACT [MONDO:patterns/cancer] +synonym: "limb bone cancer" EXACT [MONDO:patterns/location] +synonym: "malignant limb bone neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of limb bone" EXACT [MONDO:patterns/cancer] +xref: ICD10CM:C40 {source="MONDO:equivalentTo"} +is_a: MONDO:0002129 {source="MONDO:Redundant", source="MONDO:cjm"} ! bone cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002428 ! limb bone +relationship: disease_has_location UBERON:0002428 ! limb bone +property_value: exactMatch https://icd.codes/icd10cm/C40 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0024312 +name: cancer of short bone of upper limb +xref: ICD10CM:C40.1 {source="MONDO:equivalentTo"} +is_a: MONDO:0024311 {source="ICD10CM:C40.1"} ! cancer affecting bone of limb skeleton +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0002102 ! forelimb +intersection_of: disease_has_location UBERON:0013630 ! short bone +relationship: disease_has_location UBERON:0002102 ! forelimb +relationship: disease_has_location UBERON:0013630 ! short bone +property_value: exactMatch https://icd.codes/icd10cm/C40.1 + +[Term] +id: MONDO:0024313 +name: staphylococcal infection +def: "An infection caused by Staphylococcus." [NCIT:C35038] +synonym: "staphylococcal infection" EXACT [NCIT:C35038] +xref: MESH:D013203 {source="MONDO:equivalentTo"} +xref: NCIT:C35038 {source="MONDO:equivalentTo"} +xref: SCTID:56038003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005113 {source="MESH:D013203/inferred", source="MONDO:Redundant", source="NCIT:C35038"} ! bacterial infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:1279 ! Staphylococcus +relationship: disease_has_infectious_agent NCBITaxon:1279 ! Staphylococcus +property_value: exactMatch http://identifiers.org/mesh/D013203 +property_value: exactMatch http://identifiers.org/snomedct/56038003 +property_value: exactMatch NCIT:C35038 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/infectious_disease_by_agent.yaml + +[Term] +id: MONDO:0024317 +name: chronic pain syndrome +def: "Chronic form of disorder involving pain." [MONDO:patterns/chronic] +synonym: "chronic disorder involving pain" EXACT [] +synonym: "chronic pain disease" EXACT [] +synonym: "disorder involving pain, chronic" EXACT [MONDO:patterns/chronic] +xref: ICD10CM:G89.4 {source="MONDO:equivalentTo"} +xref: ICD9:338.4 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: SCTID:373621006 {source="MONDO:equivalentTo"} +xref: UMLS:C1298685 {source="MONDO:equivalentTo"} +is_a: MONDO:0700057 ! neurological pain disorder +intersection_of: MONDO:0700057 ! neurological pain disorder +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/373621006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1298685 +property_value: exactMatch https://icd.codes/icd10cm/G89.4 + +[Term] +id: MONDO:0024318 +name: viral infection of central nervous system +synonym: "central nervous system viral infection" RELATED [] +synonym: "viral disease of central nervous system" RELATED [] +synonym: "viral infection of central nervous system" EXACT [] +xref: ICD10WHO:A80-A89 {source="MONDO:equivalentTo"} +xref: MESH:D020805 {source="MONDO:equivalentTo"} +xref: SCTID:302810003 {source="MONDO:equivalentTo"} +xref: UMLS:C0348165 {source="MONDO:equivalentTo"} +is_a: MONDO:0024619 ! central nervous system infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch http://apps.who.int/classifications/icd10/browse/2010/en#/A80-A89 +property_value: exactMatch http://identifiers.org/mesh/D020805 +property_value: exactMatch http://identifiers.org/snomedct/302810003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0348165 + +[Term] +id: MONDO:0024320 +name: inner ear neoplasm +def: "A rare neoplasm that arises from the inner ear. Representative examples include lipoma and acoustic schwannoma." [NCIT:C39784] +synonym: "inner Ear neoplasm" EXACT [NCIT:C39784] +synonym: "internal Ear neoplasm" EXACT [NCIT:C39784] +synonym: "internal ear neoplasm" EXACT [] +synonym: "internal ear neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "internal ear tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of internal ear" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of internal ear" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C39784 {source="MONDO:equivalentTo"} +xref: UMLS:C1512779 {source="NCIT:C39784", source="MONDO:equivalentTo"} +is_a: MONDO:0002467 {source="MONDO:Redundant", source="NCIT:C39784"} ! inner ear disorder +is_a: MONDO:0021233 {source="MONDO:Redundant", source="NCIT:C39784"} ! ear neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001846 ! internal ear +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512779 +property_value: exactMatch NCIT:C39784 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024322 +name: disorder of glycosylation +def: "A disease that has its basis in the disruption of glycosylation." [MONDO:patterns/basis_in_disruption_of_process] +comment: May be inborn or somatic +synonym: "disorder of glycosylation" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "glycosylation disease" EXACT [MONDO:design_pattern] +is_a: MONDO:0005066 ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0070085 ! glycosylation +relationship: disease_has_basis_in_disruption_of GO:0070085 ! glycosylation +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0024327 +name: chronic renal failure syndrome +def: "Impairment of the renal function due to chronic kidney damage." [NCIT:C9438] +synonym: "chronic kidney failure" EXACT [] +synonym: "Chronic renal disease" EXACT [NCIT:C9438] +synonym: "chronic renal failure" EXACT [NCIT:C9438] +synonym: "chronic renal failure disease" EXACT [NCIT:C9438-modified] +synonym: "CRF - chronic renal failure" EXACT [NCIT:C9438] +synonym: "kidney failure, chronic" EXACT [MONDO:patterns/chronic] +xref: ICD9:585.9 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:D051436 {source="MONDO:equivalentTo"} +xref: NCIT:C9438 {source="MONDO:equivalentTo"} +xref: SCTID:90688005 {source="MONDO:equivalentTo"} +is_a: MONDO:0001106 {source="MESH:D051436", source="MONDO:Redundant", source="NCIT:C9438"} ! kidney failure +is_a: MONDO:0005300 {source="MONDO:Redundant", source="NCIT:C9438"} ! chronic kidney disease +intersection_of: MONDO:0001106 ! kidney failure +intersection_of: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/mesh/D051436 +property_value: exactMatch http://identifiers.org/snomedct/90688005 +property_value: exactMatch NCIT:C9438 + +[Term] +id: MONDO:0024330 +name: infectious otitis media +def: "Inflammation of the anatomical structures of the middle ear secondary to an infectious process. Bacterial etiology is most common, but both viral and fungal pathogens are also possible. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever. In severe infections, inflammation and edema of the structures of the middle ear can lead to perforation of the tympanic membrane secondary to the buildup of pressure in the narrow space." [NCIT:C84354] +synonym: "acute otitis Media" EXACT [NCIT:C84354] +synonym: "AOM" EXACT ABBREVIATION [NCIT:C84354] +synonym: "infectious otitis Media" EXACT [NCIT:C84354] +synonym: "middle Ear infection" EXACT [NCIT:C84354] +synonym: "otitis media" BROAD [NCIT:C84354] +xref: NCIT:C84354 {source="MONDO:equivalentTo"} +xref: UMLS:C0271429 {source="MONDO:equivalentTo"} +xref: UMLS:C2827407 {source="MONDO:equivalentTo", source="NCIT:C84354"} +is_a: MONDO:0005441 {source="MONDO:Redundant", source="NCIT:C84354"} ! otitis media +is_a: MONDO:0021666 {source="MONDO:Redundant", source="NCIT:C84354"} ! ear infection +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001756 ! middle ear +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271429 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2827407 +property_value: exactMatch NCIT:C84354 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0024331 +name: colorectal carcinoma +def: "A malignant epithelial neoplasm that arises from the colon or rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas." [NCIT:C2955] +synonym: "cancer of large bowel" BROAD [NCIT:C2955] +synonym: "cancer of large intestine" BROAD [NCIT:C2955] +synonym: "cancer of the large bowel" BROAD [NCIT:C2955] +synonym: "cancer of the large intestine" BROAD [NCIT:C2955] +synonym: "carcinoma of colorectum" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of large bowel" EXACT [NCIT:C2955] +synonym: "carcinoma of large intestine" EXACT [NCIT:C2955] +synonym: "carcinoma of the large bowel" EXACT [NCIT:C2955] +synonym: "carcinoma of the large intestine" EXACT [NCIT:C2955] +synonym: "colorectal (colon or rectal) cancer" BROAD [NCIT:C2955] +synonym: "colorectal cancer" BROAD [NCIT:C2955] +synonym: "colorectal carcinoma" EXACT [NCIT:C2955] +synonym: "colorectum carcinoma" EXACT [MONDO:patterns/location] +synonym: "CRC" EXACT ABBREVIATION [NCIT:C2955] +synonym: "large bowel cancer" BROAD [NCIT:C2955] +synonym: "large bowel carcinoma" EXACT [NCIT:C2955] +synonym: "large intestine cancer" BROAD [NCIT:C2955] +synonym: "large intestine carcinoma" EXACT [NCIT:C2955] +xref: DOID:0080199 {source="MONDO:equivalentTo"} +xref: NCIT:C2955 {source="DOID:0080199", source="MONDO:equivalentTo"} +xref: UMLS:CN221574 {source="MONDO:equivalentTo"} +is_a: MONDO:0005575 {source="DOID:0080199", source="DOID:0080199/inferred", source="MONDO:Redundant", source="NCIT:C2955"} ! colorectal cancer +is_a: MONDO:0006181 {source="MONDO:Redundant", source="NCIT:C2955"} ! digestive system carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0012652 ! colorectum +property_value: exactMatch DOID:0080199 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN221574 +property_value: exactMatch NCIT:C2955 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0024336 +name: vulvar adenocarcinoma +def: "An adenocarcinoma that arises from the vulva. Representative examples include Bartholin gland adenocarcinoma, eccrine adenocarcinoma, apocrine adenocarcinoma, and sebaceous carcinoma." [NCIT:C6380] +synonym: "adenocarcinoma of the vulva" EXACT [DOID:2098, NCIT:C6380] +synonym: "adenocarcinoma of vulva" EXACT [DOID:2098, NCIT:C6380] +synonym: "mammalian vulva adenocarcinoma" EXACT [MONDO:patterns/location] +synonym: "vulva adenocarcinoma" EXACT [MONDO:0002208] +synonym: "vulvar adenocarcinoma" EXACT [NCIT:C6380] +xref: DOID:2098 {source="MONDO:equivalentTo"} +xref: NCIT:C6380 {source="DOID:2098", source="MONDO:equivalentTo"} +xref: Orphanet:494454 {source="MONDO:equivalentTo"} +xref: UMLS:C1336975 {source="DOID:2098", source="MONDO:equivalentTo", source="NCIT:C6380"} +is_a: MONDO:0002198 {source="MONDO:Redundant", source="NCIT:C6380"} ! vulvar glandular neoplasm +is_a: MONDO:0004970 {source="DOID:2098", source="MONDO:Redundant", source="NCIT:C6380"} ! adenocarcinoma +is_a: MONDO:0005215 {source="DOID:2098", source="MONDO:Redundant", source="NCIT:C6380", source="Orphanet:494454"} ! vulvar carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:2098 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336975 +property_value: exactMatch NCIT:C6380 +property_value: exactMatch Orphanet:494454 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0024337 +name: urothelial neoplasm +def: "A neoplasm involving a urothelium." [MONDO:patterns/neoplasm] +synonym: "neoplasm of urothelium" EXACT [MONDO:patterns/neoplasm] +synonym: "transitional cell neoplasm of the urinary tract" EXACT [NCIT:C39852] +synonym: "tumor of urothelium" EXACT [MONDO:patterns/neoplasm] +synonym: "urothelial neoplasm" EXACT [NCIT:C39852] +synonym: "urothelium neoplasm" EXACT [] +synonym: "urothelium neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "urothelium tumor" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C39852 {source="MONDO:equivalentTo"} +xref: UMLS:C1519840 {source="NCIT:C39852", source="MONDO:equivalentTo"} +is_a: MONDO:0021066 {source="MONDO:Redundant", source="NCIT:C39852"} ! urinary system neoplasm +is_a: MONDO:0037254 {source="NCIT:C39852"} ! transitional cell neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000365 ! urothelium +relationship: disease_arises_from_structure CL:0000731 {source="NCIT:C39852"} ! urothelial cell +relationship: disease_arises_from_structure UBERON:0000365 {source="NCIT:C39852"} ! urothelium +relationship: disease_has_location UBERON:0000365 ! urothelium +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1519840 +property_value: exactMatch NCIT:C39852 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024339 +name: lymph node neoplasm +def: "A neoplasm involving a lymph node." [MONDO:patterns/neoplasm] +synonym: "lymph node neoplasm" EXACT [NCIT:C35497] +synonym: "lymph node neoplasm (disease)" EXACT [MONDO:patterns/location] +synonym: "lymph node tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of lymph node" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of lymph node" EXACT [MONDO:patterns/neoplasm] +xref: GARD:0006932 {source="MONDO:equivalentTo"} +xref: NCIT:C35497 {source="MONDO:equivalentTo"} +is_a: MONDO:0002334 {source="NCIT:C35497"} ! hematopoietic and lymphoid system neoplasm +is_a: MONDO:0004928 {source="MONDO:Redundant", source="NCIT:C35497"} ! lymph node disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000029 ! lymph node +property_value: exactMatch NCIT:C35497 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024341 +name: retinal cell neoplasm +def: "A neoplasm arising from the neural retina. This category includes retinoblastoma and retinocytoma." [] +synonym: "retinal cell neoplasm" EXACT [NCIT:C7061] +synonym: "retinal cell tumor" EXACT [NCIT:C7061] +synonym: "retinal neural cell neoplasm" EXACT [NCIT:C7061] +xref: NCIT:C7061 {source="MONDO:equivalentTo"} +xref: UMLS:C1335765 {source="MONDO:equivalentTo", source="NCIT:C7061"} +is_a: MONDO:0021231 {source="NCIT:C7061"} ! retina neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure UBERON:0003902 ! retinal neural layer +relationship: disease_arises_from_structure CL:0000210 {source="NCIT:C7061"} ! photoreceptor cell +relationship: disease_arises_from_structure UBERON:0003902 {source="NCIT:C7061"} ! retinal neural layer +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335765 +property_value: exactMatch NCIT:C7061 + +[Term] +id: MONDO:0024352 +name: viral respiratory tract infection +def: "A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus." [NCIT:C27219] +synonym: "viral respiratory tract infection" EXACT [NCIT:C27219] +xref: ICD9:519.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C27219 {source="MONDO:equivalentTo"} +xref: SCTID:312133006 {source="MONDO:equivalentTo"} +is_a: MONDO:0005108 {source="MONDO:Redundant", source="NCIT:C27219"} ! viral infectious disease +is_a: MONDO:0024355 ! respiratory tract infectious disorder +intersection_of: MONDO:0005108 ! viral infectious disease +intersection_of: disease_has_location UBERON:0000065 ! respiratory tract +property_value: exactMatch http://identifiers.org/snomedct/312133006 +property_value: exactMatch NCIT:C27219 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024355 +name: respiratory tract infectious disorder +def: "Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases." [MESH:D012141] +synonym: "infection, respiratory tract" RELATED [MESH:D012141] +synonym: "infections, respiratory" RELATED [MESH:D012141] +synonym: "infections, respiratory tract" RELATED [MESH:D012141] +synonym: "infections, upper respiratory" RELATED [MESH:D012141] +synonym: "infections, upper respiratory tract" RELATED [MESH:D012141] +synonym: "respiratory infection, upper" NARROW [MESH:D012141] +synonym: "respiratory infections" RELATED [MESH:D012141] +synonym: "respiratory tract infection" RELATED [MESH:D012141] +synonym: "upper respiratory infections" NARROW [MESH:D012141] +synonym: "upper respiratory tract infections" NARROW [MESH:D012141] +xref: ICD9:519.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012141 {source="MONDO:equivalentTo"} +xref: SCTID:275498002 {source="MONDO:equivalentTo"} +is_a: MONDO:0005087 ! respiratory system disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0000065 ! respiratory tract +relationship: disease_has_location UBERON:0000065 ! respiratory tract +property_value: exactMatch http://identifiers.org/mesh/D012141 +property_value: exactMatch http://identifiers.org/snomedct/275498002 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024387 +name: benign ovarian sex cord-stromal tumor +def: "A sex cord-stromal tumor arising from the ovary, without metastatic potential." [NCIT:C6803] +synonym: "benign ovarian Sex cord-stromal neoplasm" EXACT [NCIT:C6803] +synonym: "benign ovarian Sex cord-stromal tumor" EXACT [NCIT:C6803] +synonym: "benign Sex cord-stromal neoplasm of ovary" EXACT [NCIT:C6803] +synonym: "benign Sex cord-stromal neoplasm of the ovary" EXACT [NCIT:C6803] +synonym: "benign Sex cord-stromal tumor of ovary" EXACT [NCIT:C6803] +synonym: "benign Sex cord-stromal tumor of the ovary" EXACT [NCIT:C6803] +synonym: "ovarian SEX cord-stromal tumor, benign" EXACT [NCIT:C6803] +synonym: "ovarian sex cord-stromal tumor, benign" EXACT [MONDO:patterns/benign] +synonym: "Sex cord stromal tumor, benign" EXACT [NCIT:C6803] +xref: DOID:0080370 {source="MONDO:equivalentTo"} +xref: NCIT:C6803 {source="MONDO:equivalentTo"} +xref: UMLS:C1332528 {source="MONDO:equivalentTo"} +is_a: MONDO:0000646 {source="MONDO:Redundant", source="NCIT:C6803"} ! ovarian benign neoplasm +is_a: MONDO:0021657 {source="MONDO:Redundant", source="NCIT:C6803"} ! ovarian sex cord-stromal tumor +is_a: MONDO:0024988 ! sex cord-stromal benign neoplasm +intersection_of: MONDO:0021657 ! ovarian sex cord-stromal tumor +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:0080370 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1332528 +property_value: exactMatch NCIT:C6803 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0024417 +name: perceptual disorders +def: "Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body." [MESH:D010468] +xref: MESH:D010468 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0007600 ! sensory perception +relationship: disease_disrupts GO:0007600 ! sensory perception +property_value: exactMatch http://identifiers.org/mesh/D010468 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0024422 +name: auditory perceptual disorders +def: "Acquired or developmental cognitive disorders of AUDITORY PERCEPTION characterized by a reduced ability to perceive information contained in auditory stimuli despite intact auditory pathways. Affected individuals have difficulty with speech perception, sound localization, and comprehending the meaning of inflections of speech." [MESH:D001308] +synonym: "acoustic perceptual disorder" NARROW [MESH:D001308] +synonym: "acoustic perceptual disorders" NARROW [MESH:D001308] +synonym: "auditory comprehension disorder" NARROW [MESH:D001308] +synonym: "auditory comprehension disorders" NARROW [MESH:D001308] +synonym: "auditory inattention" NARROW [MESH:D001308] +synonym: "auditory Inattentions" NARROW [MESH:D001308] +synonym: "auditory perceptual disorder" NARROW [MESH:D001308] +synonym: "auditory processing disorder" NARROW [MESH:D001308] +synonym: "auditory processing disorders" NARROW [MESH:D001308] +synonym: "comprehension disorder, auditory" NARROW [MESH:D001308] +synonym: "comprehension disorders, auditory" NARROW [MESH:D001308] +synonym: "disorder of sensory perception of sound" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder, acoustic perceptual" NARROW [MESH:D001308] +synonym: "disorder, auditory comprehension" NARROW [MESH:D001308] +synonym: "disorder, auditory processing" NARROW [MESH:D001308] +synonym: "disorder, Psychoacoustical" NARROW [MESH:D001308] +synonym: "disorders, acoustic perceptual" NARROW [MESH:D001308] +synonym: "disorders, auditory comprehension" NARROW [MESH:D001308] +synonym: "disorders, auditory processing" NARROW [MESH:D001308] +synonym: "disorders, Psychoacoustical" NARROW [MESH:D001308] +synonym: "inattention, auditory" NARROW [MESH:D001308] +synonym: "Inattentions, auditory" NARROW [MESH:D001308] +synonym: "perceptual disorder, acoustic" NARROW [MESH:D001308] +synonym: "perceptual disorder, auditory" NARROW [MESH:D001308] +synonym: "perceptual disorders, acoustic" NARROW [MESH:D001308] +synonym: "perceptual disorders, auditory" NARROW [MESH:D001308] +synonym: "processing disorder, auditory" NARROW [MESH:D001308] +synonym: "processing disorders, auditory" NARROW [MESH:D001308] +synonym: "Psychoacoustical disorder" NARROW [MESH:D001308] +synonym: "Psychoacoustical disorders" NARROW [MESH:D001308] +synonym: "sensory perception of sound disease" EXACT [MONDO:design_pattern] +xref: MESH:D001308 {source="MONDO:equivalentTo"} +xref: NCIT:C84575 {source="MONDO:equivalentTo"} +xref: SCTID:229752008 {source="MONDO:equivalentTo"} +xref: UMLS:C0751257 {source="MONDO:equivalentTo"} +is_a: MONDO:0021945 ! hearing disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0007605 ! sensory perception of sound +relationship: disease_has_basis_in_disruption_of GO:0007605 ! sensory perception of sound +property_value: exactMatch http://identifiers.org/mesh/D001308 +property_value: exactMatch http://identifiers.org/snomedct/229752008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751257 +property_value: exactMatch NCIT:C84575 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0024432 +name: nerve plexus disorder +def: "A disease that involves the nerve plexus." [MONDO:patterns/location] +synonym: "disease of nerve plexus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nerve plexus" EXACT [] +synonym: "disorder of nerve plexus" EXACT [MONDO:patterns/location_top] +synonym: "nerve plexus disease" EXACT [MONDO:patterns/location] +synonym: "nerve plexus disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "nerve plexus disorder" EXACT [] +synonym: "plexopathy" EXACT [MONDO:cjm] +xref: DOID:3688 {source="MONDO:equivalentTo"} +xref: NCIT:C27744 {source="MONDO:equivalentTo", source="DOID:3688"} +xref: SCTID:2231001 {source="MONDO:equivalentTo"} +xref: UMLS:C1335437 {source="MONDO:equivalentTo", source="DOID:3688", source="NCIT:C27744"} +is_a: MONDO:0005244 ! peripheral neuropathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001810 ! nerve plexus +relationship: disease_has_location UBERON:0001810 ! nerve plexus +property_value: exactMatch DOID:3688 +property_value: exactMatch http://identifiers.org/snomedct/2231001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335437 +property_value: exactMatch NCIT:C27744 +property_value: excluded_subClassOf MONDO:0005559 {source="DOID:3688"} +property_value: excluded_subClassOf MONDO:0024236 {source="NCIT:C27744"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024458 +name: disorder of visual system +def: "A disease that involves the visual system." [MONDO:patterns/location] +synonym: "disease of visual system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of visual system" EXACT [] +synonym: "disorder of visual system" EXACT [MONDO:patterns/location_top] +synonym: "visual system disease" EXACT [MONDO:patterns/location] +synonym: "visual system disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "visual system disorder" EXACT [] +xref: SCTID:128127008 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002104 ! visual system +relationship: disease_has_location UBERON:0002104 ! visual system +property_value: exactMatch http://identifiers.org/snomedct/128127008 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024467 +name: apocrine sweat gland disorder +def: "A disease that involves the apocrine sweat gland." [MONDO:patterns/location] +synonym: "apocrine sweat gland disease" EXACT [MONDO:patterns/location] +synonym: "apocrine sweat gland disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of apocrine sweat gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of apocrine sweat gland" EXACT [] +synonym: "disorder of apocrine sweat gland" EXACT [MONDO:patterns/location_top] +xref: ICD10CM:L75 {source="MONDO:equivalentTo"} +is_a: MONDO:0006615 ! sweat gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000382 ! apocrine sweat gland +relationship: disease_has_location UBERON:0000382 ! apocrine sweat gland +property_value: exactMatch https://icd.codes/icd10cm/L75 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024468 +name: anterior pituitary gland disorder +def: "A disease that involves the adenohypophysis." [MONDO:patterns/location] +synonym: "adenohypophysis disease" EXACT [MONDO:patterns/location] +synonym: "adenohypophysis disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "disease of adenohypophysis" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of adenohypophysis" EXACT [] +synonym: "disorder of adenohypophysis" EXACT [MONDO:patterns/location_top] +synonym: "disorder of anterior pituitary" EXACT [] +synonym: "disorder of anterior pituitary gland" RELATED [] +xref: ICD9:253.4 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:253.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:51742006 {source="MONDO:equivalentTo"} +is_a: MONDO:0003381 {source="MONDO:Redundant"} ! pituitary gland disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002196 ! adenohypophysis +relationship: disease_has_feature HP:0000830 ! Anterior hypopituitarism +relationship: disease_has_location UBERON:0002196 ! adenohypophysis +property_value: exactMatch http://identifiers.org/snomedct/51742006 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024476 +name: epithelial neoplasm of rectum +def: "A epithelial neoplasm that involves the rectum." [MONDO:patterns/location] +synonym: "rectal epithelial neoplasm" EXACT [] +synonym: "rectal epithelial tumor" EXACT [] +synonym: "rectum epithelial neoplasm" EXACT [MONDO:patterns/location] +is_a: MONDO:0002165 ! rectal neoplasm +is_a: MONDO:0005626 ! epithelial neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0001052 ! rectum + +[Term] +id: MONDO:0024477 +name: liver and intrahepatic bile duct neoplasm +def: "A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma." [NCIT:C7103] +synonym: "hepatic and intrahepatic bile duct neoplasm" EXACT [NCIT:C7103] +synonym: "liver and intrahepatic bile duct neoplasm" EXACT [NCIT:C7103] +xref: NCIT:C7103 {source="MONDO:equivalentTo"} +xref: UMLS:C1333976 {source="NCIT:C7103", source="MONDO:equivalentTo"} +is_a: MONDO:0002514 {source="NCIT:C7103"} ! hepatobiliary neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333976 +property_value: exactMatch NCIT:C7103 + +[Term] +id: MONDO:0024479 +name: epithelial tumor of colon +def: "A epithelial neoplasm that involves the colon." [MONDO:patterns/location] +synonym: "colon epithelial neoplasm" EXACT [MONDO:patterns/location] +is_a: MONDO:0005401 ! colonic neoplasm +is_a: MONDO:0005626 ! epithelial neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: disease_has_location UBERON:0001155 ! colon + +[Term] +id: MONDO:0024481 +name: skin appendage disorder +def: "A disease that involves the cutaneous appendage." [MONDO:patterns/location] +synonym: "cutaneous appendage disease" EXACT [MONDO:patterns/location] +synonym: "cutaneous appendage disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of cutaneous appendage" EXACT [MONDO:patterns/location_top] +synonym: "disease of epidermal appendage" RELATED [] +synonym: "disease of epidermal appendages" RELATED [] +synonym: "disease or disorder of cutaneous appendage" EXACT [] +synonym: "disorder of cutaneous appendage" EXACT [MONDO:patterns/location_top] +synonym: "disorder of skin appendage" EXACT [] +xref: ICD10CM:L60-L75 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: SCTID:238714008 {source="MONDO:equivalentTo"} +xref: UMLS:C0037272 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 ! integumentary system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000021 ! cutaneous appendage +relationship: disease_has_location UBERON:0000021 ! cutaneous appendage +property_value: exactMatch http://identifiers.org/snomedct/238714008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037272 +property_value: exactMatch https://icd.codes/icd10cm/L60-L75 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024483 +name: urothelial hyperplasia +def: "Hyperplasia of the transitional epithelium of the urinary tract. Morphologically it is subdivided into flat and papillary hyperplasia. -- 2003" [NCIT:C27877] +synonym: "urothelial hyperplasia" EXACT [NCIT:C27877] +synonym: "urothelium hyperplasia" EXACT [MONDO:patterns/location] +xref: NCIT:C27877 {source="MONDO:equivalentTo"} +is_a: MONDO:0002118 ! urinary system disorder +is_a: MONDO:0005043 {source="MONDO:Redundant", source="NCIT:C27877"} ! hyperplasia +intersection_of: MONDO:0005043 ! hyperplasia +intersection_of: disease_has_location UBERON:0000365 ! urothelium +relationship: disease_has_location UBERON:0000365 ! urothelium +property_value: exactMatch NCIT:C27877 + +[Term] +id: MONDO:0024487 +name: nail infection +def: "An infectious process affecting the nail." [NCIT:C78493] +synonym: "nail infection" EXACT [NCIT:C78493] +xref: NCIT:C78493 {source="MONDO:equivalentTo"} +xref: UMLS:C0343026 {source="NCIT:C78493", source="MONDO:equivalentTo"} +is_a: MONDO:0002884 ! nail disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0001705 ! nail +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0343026 +property_value: exactMatch NCIT:C78493 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024488 +name: tumor grading characteristic +def: "A modifier that can be applied to a tumor class describing abnormal tumor histology or morphology. It is an indicator of how quickly a tumor is likely to grow and spread" [https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet] +is_a: MONDO:0021125 ! disease characteristic + +[Term] +id: MONDO:0024489 +name: general tumor grading characteristic +def: "A term that refers to the cellular differentiation of a malignant cellular infiltrate. A cancer is defined through grades I-IV (or 1-4), or as well, moderately, poorly differentiated or undifferentiated." [NCIT:C28076] +synonym: "disease grade qualifier" EXACT [NCIT:C28076] +xref: NCIT:C28076 {source="MONDO:equivalentTo"} +is_a: MONDO:0024488 ! tumor grading characteristic +property_value: exactMatch NCIT:C28076 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0024491 +name: tumor grade 1, general grading system +def: "A morphologic qualifier indicating that a cancerous lesion is well differentiated." [NCIT:C28077] +synonym: "G1" EXACT ABBREVIATION [NCIT:C28077] +synonym: "grade 1" EXACT [NCIT:C28077] +synonym: "grade I" EXACT [NCIT:C28077] +synonym: "low grade" EXACT [] +synonym: "well differentiated" EXACT [] +xref: LOINC:LA9629-2 +xref: NCIT:C28077 {source="MONDO:equivalentTo"} +xref: UMLS:C0475269 {source="MONDO:equivalentTo"} +is_a: MONDO:0024495 ! tumor grade 1 or 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0475269 +property_value: exactMatch NCIT:C28077 + +[Term] +id: MONDO:0024492 +name: tumor grade 2, general grading system +def: "A morphologic qualifier indicating that a cancerous lesion is moderately differentiated." [NCIT:C28078] +synonym: "G2" EXACT ABBREVIATION [NCIT:C28078] +synonym: "grade 2" EXACT [NCIT:C28078] +synonym: "grade II" EXACT [NCIT:C28078] +synonym: "intermediate grade" EXACT [] +synonym: "moderately differentiated" EXACT [] +xref: EFO:0005746 {source="MONDO:equivalentTo"} +xref: NCIT:C28078 {source="MONDO:equivalentTo"} +is_a: MONDO:0024495 ! tumor grade 1 or 2, general grading system +is_a: MONDO:0024496 ! tumor grade 2 or 3, general grading system +property_value: exactMatch NCIT:C28078 + +[Term] +id: MONDO:0024493 +name: tumor grade 3, general grading system +def: "A morphologic qualifier indicating that a cancerous lesion is poorly differentiated." [NCIT:C28079] +synonym: "G3" EXACT ABBREVIATION [NCIT:C28079] +synonym: "grade 3" EXACT [NCIT:C28079] +synonym: "grade III" EXACT [NCIT:C28079] +synonym: "high grade" BROAD [] +synonym: "poorly differentiated" EXACT [] +xref: NCIT:C28079 {source="MONDO:equivalentTo"} +xref: UMLS:C0475271 {source="MONDO:equivalentTo"} +is_a: MONDO:0024496 ! tumor grade 2 or 3, general grading system +is_a: MONDO:0024497 ! tumor grade 3 or 4, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0475271 +property_value: exactMatch NCIT:C28079 + +[Term] +id: MONDO:0024494 +name: tumor grade 4, general grading system +def: "A morphologic qualifier indicating that a cancerous lesion is undifferentiated." [NCIT:C28082] +synonym: "G4" EXACT ABBREVIATION [NCIT:C28082] +synonym: "grade 4" EXACT [NCIT:C28082] +synonym: "grade IV" EXACT [NCIT:C28082] +synonym: "high grade" BROAD [] +synonym: "undifferentiated" EXACT [] +xref: NCIT:C28082 {source="MONDO:equivalentTo"} +is_a: MONDO:0024497 ! tumor grade 3 or 4, general grading system +property_value: exactMatch NCIT:C28082 + +[Term] +id: MONDO:0024495 +name: tumor grade 1 or 2, general grading system +synonym: "grade 1/2" EXACT [MONDO:cjm] +is_a: MONDO:0024489 ! general tumor grading characteristic +union_of: MONDO:0024491 ! tumor grade 1, general grading system +union_of: MONDO:0024492 ! tumor grade 2, general grading system + +[Term] +id: MONDO:0024496 +name: tumor grade 2 or 3, general grading system +def: "A morphologic qualifier indicating that a neoplastic lesion is moderately to poorly differentiated." [NCIT:C94678] +synonym: "grade 2/3" EXACT [NCIT:C94678] +xref: NCIT:C94678 {source="MONDO:equivalentTo"} +is_a: MONDO:0024489 {source="NCIT:C94678"} ! general tumor grading characteristic +union_of: MONDO:0024492 ! tumor grade 2, general grading system +union_of: MONDO:0024493 ! tumor grade 3, general grading system +property_value: exactMatch NCIT:C94678 + +[Term] +id: MONDO:0024497 +name: tumor grade 3 or 4, general grading system +def: "Used to describe tumor samples that exhibit poorly differentiated or undifferentiated cells. They are generally expected to be fast growing and aggressive." [NCIT:C14158] +synonym: "grade 3/4" EXACT [MONDO:cjm] +synonym: "high grade" EXACT [MONDO:cjm, NCIT:C14158] +xref: NCIT:C14158 {source="MONDO:equivalentTo"} +is_a: MONDO:0024489 {source="NCIT:C14158/inferred"} ! general tumor grading characteristic +union_of: MONDO:0024493 ! tumor grade 3, general grading system +union_of: MONDO:0024494 ! tumor grade 4, general grading system +property_value: exactMatch NCIT:C14158 + +[Term] +id: MONDO:0024499 +name: vascular bone neoplasm +def: "A benign, intermediate, or malignant vascular neoplasm that arises from the bone." [NCIT:C6478] +synonym: "bone vascular neoplasm" EXACT [NCIT:C6478] +synonym: "bone vascular tumor" EXACT [NCIT:C6478] +synonym: "osseous vascular neoplasm" EXACT [NCIT:C6478] +synonym: "osseous vascular tumor" EXACT [NCIT:C6478] +synonym: "vascular bone neoplasm" EXACT [NCIT:C6478] +synonym: "vascular neoplasm of bone" EXACT [NCIT:C6478] +synonym: "vascular neoplasm of the bone" EXACT [NCIT:C6478] +synonym: "vascular tumor of bone" EXACT [NCIT:C6478] +synonym: "vascular tumor of the bone" EXACT [NCIT:C6478] +xref: NCIT:C6478 {source="MONDO:equivalentTo"} +xref: UMLS:C1336946 {source="MONDO:equivalentTo", source="NCIT:C6478"} +is_a: MONDO:0019060 ! bone neoplasm +is_a: MONDO:0024296 {source="MONDO:Entailed", source="NCIT:C6478"} ! vascular neoplasm +intersection_of: MONDO:0024296 ! vascular neoplasm +intersection_of: disease_has_location UBERON:0002481 ! bone tissue +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336946 +property_value: exactMatch NCIT:C6478 + +[Term] +id: MONDO:0024500 +name: duodenal neuroendocrine neoplasm +def: "A neuroendocrine neoplasm that involves the duodenum." [MONDO:patterns/location] +synonym: "duodenum NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "duodenum neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "duodenum neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "duodenum neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of duodenum" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +is_a: MONDO:0018510 ! small intestine neuroendocrine neoplasm +is_a: MONDO:0021375 ! tumor of duodenum +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002114 ! duodenum +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0024501 +name: appendix neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the appendix. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C60709] +synonym: "appendix neuroendocrine neoplasm" EXACT [NCIT:C60709] +synonym: "neuroendocrine neoplasm of vermiform appendix" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "vermiform appendix NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "vermiform appendix neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "vermiform appendix neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "vermiform appendix neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: NCIT:C60709 {source="MONDO:equivalentTo"} +is_a: MONDO:0001236 {source="MONDO:Redundant", source="NCIT:C60709"} ! appendiceal neoplasm +is_a: MONDO:0002882 ! colon neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch NCIT:C60709 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0024502 +name: gallbladder neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation that arises from the gallbladder. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)." [NCIT:C96917] +synonym: "gall bladder NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "gall bladder neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "gall bladder neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "gall bladder neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "gallbladder neuroendocrine neoplasm" EXACT [NCIT:C96917] +synonym: "neuroendocrine neoplasm of gall bladder" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +xref: NCIT:C96917 {source="MONDO:equivalentTo"} +xref: UMLS:C3273115 {source="MONDO:equivalentTo", source="NCIT:C96917"} +is_a: MONDO:0021253 {source="MONDO:Redundant", source="NCIT:C96917"} ! gallbladder neoplasm +is_a: MONDO:0024503 ! digestive system neuroendocrine neoplasm +is_a: MONDO:0025511 ! inherited neuroendocrine tumor +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0002110 ! gall bladder +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3273115 +property_value: exactMatch NCIT:C96917 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml + +[Term] +id: MONDO:0024503 +name: digestive system neuroendocrine neoplasm +def: "A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas)." [NCIT:C27721] +subset: disease_grouping +subset: gard_rare {source="GARD:0002437"} +subset: ordo_group_of_disorders {source="Orphanet:100092"} +synonym: "alimentary part of gastrointestinal system NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "alimentary part of gastrointestinal system neuroendocrine neoplasm" EXACT [MONDO:patterns/location] +synonym: "alimentary part of gastrointestinal system neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "carcinoid tumor" RELATED [PMID:24714698, Wikipedia:Neuroendocrine_tumor#Gastroenteropancreatic_neuroendocrine_tumors_(GEP-NET)] +synonym: "carcinoid tumor of digestive system" EXACT [MONDO:cjm] +synonym: "digestive system NET" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "digestive system neuroendocrine neoplasm" EXACT [MONDO:patterns/location, NCIT:C27721] +synonym: "digestive system neuroendocrine tumor" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "digestive system neuroendocrine tumor, well differentiated, low or intermediate grade" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +synonym: "gastro-enteropancreatic neuroendocrine tumor" EXACT [MONDO:0023217] +synonym: "gastroenteropancreatic endocrine tumor" EXACT [Orphanet:100092] +synonym: "gastroenteropancreatic neuroendocrine neoplasm" EXACT [GARD:0002437, NCIT:C27721] +synonym: "gastrointestinal neuroendocrine neoplasm" EXACT [NCIT:C27721] +synonym: "gastrointestinal system neuroendocrine neoplasm" EXACT [NCIT:C27721] +synonym: "GEP tumors" RELATED [GARD:0002437] +synonym: "GEP-NEN" RELATED [Orphanet:100092] +synonym: "GEP-NET" RELATED [Orphanet:100092] +synonym: "neuroendocrine neoplasm of alimentary part of gastrointestinal system" EXACT [MONDO:design_pattern, MONDO:patterns/neuroendocrine_neoplasm] +synonym: "neuroendocrine neoplasm of digestive system" EXACT [MONDO:patterns/neuroendocrine_neoplasm] +xref: GARD:0002437 {source="MONDO:equivalentTo"} +xref: MESH:C535650 {source="MONDO:equivalentTo"} +xref: NCIT:C27721 {source="MONDO:equivalentTo"} +xref: Orphanet:100092 {source="MONDO:equivalentTo"} +xref: UMLS:CN197371 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 ! digestive system disorder +is_a: MONDO:0019496 {source="MONDO:Redundant", source="NCIT:C27721"} ! neuroendocrine neoplasm +is_a: MONDO:0021223 {source="MONDO:Redundant", source="NCIT:C27721"} ! digestive system neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +property_value: exactMatch http://identifiers.org/mesh/C535650 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN197371 +property_value: exactMatch NCIT:C27721 +property_value: exactMatch Orphanet:100092 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo neuroendocrine:neoplasm.yaml +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/2437/gastro-enteropancreatic-neuroendocrine-tumor xsd:anyURI {source="GARD:0002437"} + +[Term] +id: MONDO:0024575 +name: pregnancy disorder +def: "A disorder that is related to pregnancy. Representative examples include ectopic pregnancy, toxemia of pregnancy, and gestational trophoblastic tumor." [NCIT:C35169] +synonym: "complication of pregnancy or childbirth" EXACT [] +synonym: "complication, pregnancy" RELATED [MESH:D011248] +synonym: "Complications, pregnancy" RELATED [MESH:D011248] +synonym: "disorder of pregnancy" EXACT [NCIT:C35169] +synonym: "disorder of pregnancy, childbirth, or puerperium" EXACT [] +synonym: "pregnancy complication" RELATED [MESH:D011248] +synonym: "pregnancy disease" EXACT [] +synonym: "pregnancy disorder" EXACT [NCIT:C35169] +xref: MESH:D011248 {source="MONDO:equivalentTo"} +xref: NCIT:C35169 {source="MONDO:equivalentTo"} +xref: SCTID:173300003 {source="MONDO:equivalentTo"} +is_a: MONDO:0700003 {source="https://github.com/monarch-initiative/mondo/issues/3161", source="https://orcid.org/0000-0002-4142-7153"} ! obstetric disorder +relationship: disease_has_basis_in_disruption_of GO:0007565 ! female pregnancy +relationship: disease_has_location UBERON:0009097 ! gravid organism +property_value: exactMatch http://identifiers.org/mesh/D011248 +property_value: exactMatch http://identifiers.org/snomedct/173300003 +property_value: exactMatch NCIT:C35169 +property_value: excluded_subClassOf MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/652"} +property_value: excluded_subClassOf MONDO:0002263 {source="NCIT:C35169"} + +[Term] +id: MONDO:0024582 +name: male reproductive system neoplasm +def: "A benign, borderline, or malignant neoplasm that affects the male reproductive system. Representative examples include benign prostate phyllodes tumor, benign testicular Sertoli cell tumor, prostatic intraepithelial neoplasia, prostate carcinoma, testicular seminoma, and testicular embryonal carcinoma." [NCIT:C3054] +synonym: "male reproductive organ neoplasm" EXACT [] +synonym: "male reproductive organ tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "Male reproductive system neoplasm" EXACT [NCIT:C3054] +synonym: "Male reproductive system tumor" EXACT [NCIT:C3054] +synonym: "neoplasm of male reproductive organ" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of Male reproductive system" EXACT [NCIT:C3054] +synonym: "neoplasm of the Male reproductive system" EXACT [NCIT:C3054] +synonym: "tumor of male reproductive organ" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of Male reproductive system" EXACT [NCIT:C3054] +synonym: "tumor of the Male reproductive system" EXACT [NCIT:C3054] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C3054 {source="MONDO:equivalentTo"} +xref: SCTID:126895004 {source="MONDO:equivalentTo"} +is_a: MONDO:0003150 {source="MONDO:Redundant", source="NCIT:C3054"} ! male reproductive system disorder +is_a: MONDO:0006054 {source="MONDO:Redundant", source="NCIT:C3054"} ! reproductive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003135 ! male reproductive organ +relationship: disease_has_location UBERON:0003135 ! male reproductive organ +property_value: exactMatch http://identifiers.org/snomedct/126895004 +property_value: exactMatch NCIT:C3054 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024609 +name: vulvar squamous cell carcinoma +def: "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)" [NCIT:C4052] +synonym: "epidermoid carcinoma of the vulva" EXACT [NCIT:C4052] +synonym: "epidermoid carcinoma of vulva" EXACT [NCIT:C4052] +synonym: "epidermoid cell carcinoma of the vulva" EXACT [NCIT:C4052] +synonym: "epidermoid cell carcinoma of vulva" EXACT [NCIT:C4052] +synonym: "mammalian vulva squamous cell carcinoma" EXACT [MONDO:patterns/location] +synonym: "squamous cell carcinoma of the vulva" EXACT [NCIT:C4052] +synonym: "squamous cell carcinoma of vulva" EXACT [DOID:2101, NCIT:C4052] +synonym: "vulva epidermoid carcinoma" EXACT [NCIT:C4052] +synonym: "vulva epidermoid cell carcinoma" EXACT [NCIT:C4052] +synonym: "vulva squamous cell carcinoma" EXACT [MONDO:0002210, NCIT:C4052] +synonym: "vulvar epidermoid carcinoma" EXACT [DOID:2101, NCIT:C4052] +synonym: "vulvar epidermoid cell carcinoma" EXACT [NCIT:C4052] +synonym: "vulvar squamous cell cancer" EXACT [NCIT:C4052] +synonym: "vulvar squamous cell carcinoma" EXACT [DOID:2101, MONDO:0006492, NCIT:C4052] +xref: DOID:2101 {source="MONDO:equivalentTo"} +xref: EFO:1000624 {source="MONDO:equivalentTo"} +xref: NCIT:C4052 {source="DOID:2101", source="MONDO:equivalentTo", source="EFO:1000624"} +xref: Orphanet:494448 {source="MONDO:equivalentTo"} +xref: SCTID:254895003 {source="DOID:2101", source="MONDO:equivalentTo"} +xref: UMLS:C0280856 {source="NCIT:C4052", source="DOID:2101", source="MONDO:equivalentTo"} +is_a: MONDO:0002195 {source="MONDO:Redundant", source="NCIT:C4052"} ! vulvar squamous neoplasm +is_a: MONDO:0005096 {source="DOID:2101", source="EFO:1000624", source="MONDO:Redundant", source="NCIT:C4052"} ! squamous cell carcinoma +is_a: MONDO:0005215 {source="DOID:2101", source="EFO:1000624", source="MONDO:Redundant", source="NCIT:C4052", source="Orphanet:494448"} ! vulvar carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch DOID:2101 +property_value: exactMatch http://identifiers.org/snomedct/254895003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280856 +property_value: exactMatch NCIT:C4052 +property_value: exactMatch Orphanet:494448 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0024611 +name: orbit neoplasm +def: "A benign or malignant neoplasm that affects the orbit." [NCIT:C3290] +synonym: "neoplasm of orbit" EXACT [NCIT:C3290] +synonym: "neoplasm of orbit of skull" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of the orbit" EXACT [NCIT:C3290] +synonym: "orbit neoplasm" EXACT [NCIT:C3290] +synonym: "orbit of skull neoplasm" EXACT [] +synonym: "orbit of skull tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "orbit tumor" EXACT [NCIT:C3290] +synonym: "orbital neoplasm" EXACT [NCIT:C3290] +synonym: "orbital neoplasms" EXACT [NCIT:C3290] +synonym: "orbital tumor" EXACT [NCIT:C3290] +synonym: "tumor of orbit" EXACT [NCIT:C3290] +synonym: "tumor of orbit of skull" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of the orbit" EXACT [NCIT:C3290] +xref: NCIT:C3290 {source="MONDO:equivalentTo"} +is_a: MONDO:0002022 ! disorder of orbital region +is_a: MONDO:0023369 ! disorder of facial skeleton +is_a: MONDO:0024653 ! skull neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001697 ! orbit of skull +relationship: disease_has_location UBERON:0001697 ! orbit of skull +property_value: exactMatch NCIT:C3290 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024616 +name: tympanitis +def: "An inflammatory disease involving a pathogenic inflammatory response in the tympanic membrane." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of tympanic membrane" EXACT [] +synonym: "myringitis" EXACT [] +synonym: "tympanic membrane inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: SCTID:14852000 {source="MONDO:equivalentTo"} +xref: UMLS:C0027134 {source="MONDO:equivalentTo"} +is_a: MONDO:0003648 ! tympanic membrane disorder +is_a: MONDO:0005441 ! otitis media +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002364 ! tympanic membrane +relationship: disease_has_inflammation_site UBERON:0002364 ! tympanic membrane +property_value: exactMatch http://identifiers.org/snomedct/14852000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0027134 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0024619 +name: central nervous system infectious disorder +def: "An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis." [NCIT:C27582] +synonym: "central nervous system infection" RELATED [MESH:D002494] +synonym: "central nervous system infectious disease" EXACT [MONDO:patterns/location, NCIT:C27582] +synonym: "central nervous system infectious disorder" EXACT [NCIT:C27582] +synonym: "infections, central nervous system" RELATED [MESH:D002494] +synonym: "infectious disease of central nervous system" EXACT [MONDO:0021684, NCIT:C27582] +xref: EFO:1001456 {source="MONDO:equivalentTo"} +xref: ICD9:349.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D002494 {source="MONDO:equivalentTo"} +xref: NCIT:C27582 {source="MONDO:equivalentTo"} +xref: SCTID:128117002 {source="MONDO:equivalentTo"} +xref: UMLS:C0007684 {source="NCIT:C27582", source="MONDO:equivalentTo"} +is_a: MONDO:0002602 {source="MESH:D002494", source="MONDO:Redundant", source="NCIT:C27582/inferred"} ! central nervous system disorder +is_a: MONDO:0020010 {source="MONDO:Redundant", source="NCIT:C27582"} ! infectious disorder of the nervous system +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch http://identifiers.org/mesh/D002494 +property_value: exactMatch http://identifiers.org/snomedct/128117002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0007684 +property_value: exactMatch NCIT:C27582 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0024622 +name: thyroid gland adenocarcinoma +def: "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)." [NCIT:C27380] +synonym: "thyroid adenocarcinoma" EXACT [NCIT:C27380] +synonym: "thyroid gland adenocarcinoma" EXACT [NCIT:C27380] +xref: DOID:0080524 {source="MONDO:equivalentTo"} +xref: NCIT:C27380 {source="MONDO:equivalentTo"} +is_a: MONDO:0004970 {source="MONDO:Redundant", source="NCIT:C27380"} ! adenocarcinoma +is_a: MONDO:0015075 {source="MONDO:Redundant", source="NCIT:C27380"} ! thyroid gland carcinoma +intersection_of: MONDO:0004970 ! adenocarcinoma +intersection_of: disease_has_location UBERON:0002046 ! thyroid gland +property_value: exactMatch DOID:0080524 +property_value: exactMatch NCIT:C27380 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/adenocarcinoma.yaml + +[Term] +id: MONDO:0024623 +name: otorhinolaryngologic disease +def: "Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases." [MESH:D010038] +comment: Editor note: consider uberon class +synonym: "disease, ENT" RELATED [MESH:D010038] +synonym: "disease, otolaryngologic" RELATED [MESH:D010038] +synonym: "disease, otolaryngological" RELATED [MESH:D010038] +synonym: "disease, otorhinolaryngologic" RELATED [MESH:D010038] +synonym: "disease, otorhinolaryngological" RELATED [MESH:D010038] +synonym: "diseases, ENT" RELATED [MESH:D010038] +synonym: "diseases, otolaryngologic" RELATED [MESH:D010038] +synonym: "diseases, otolaryngological" RELATED [MESH:D010038] +synonym: "diseases, otorhinolaryngologic" RELATED [MESH:D010038] +synonym: "diseases, otorhinolaryngological" RELATED [MESH:D010038] +synonym: "ear, nose and throat disorder" EXACT [] +synonym: "ear, nose or throat disorder" EXACT [] +synonym: "ear/nose/throat disease" EXACT [https://orcid.org/0000-0002-0736-9199] +synonym: "ENT disease" RELATED [MESH:D010038] +synonym: "ENT diseases" RELATED [MESH:D010038] +synonym: "otolaryngologic disease" RELATED [MESH:D010038] +synonym: "otolaryngologic diseases" RELATED [MESH:D010038] +synonym: "otolaryngologic disorder" EXACT [NCIT:C118420] +synonym: "otolaryngological disease" RELATED [MESH:D010038] +synonym: "otolaryngological diseases" RELATED [MESH:D010038] +synonym: "otorhinolaryngologic disease" EXACT [MESH:D010038] +synonym: "otorhinolaryngological disease" RELATED [MESH:D010038] +synonym: "otorhinolaryngological diseases" RELATED [MESH:D010038] +xref: ICD9:478.19 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D010038 {source="MONDO:equivalentTo"} +xref: NCIT:C118420 {source="MONDO:equivalentTo"} +xref: SCTID:232208008 {source="MONDO:equivalentTo"} +xref: UMLS:C0029896 {source="MONDO:equivalentTo"} +xref: UMLS:C0395797 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 {source="NCIT:C118420/inferred"} ! disease or disorder +relationship: disease_has_location UBERON:0007811 ! craniocervical region +property_value: exactMatch http://identifiers.org/mesh/D010038 +property_value: exactMatch http://identifiers.org/snomedct/232208008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0029896 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0395797 +property_value: exactMatch NCIT:C118420 + +[Term] +id: MONDO:0024625 +name: disorder of lacrimal gland +def: "A disease that involves the lacrimal gland." [MONDO:patterns/location] +synonym: "disease of lacrimal gland" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lacrimal gland" EXACT [] +synonym: "disorder of lacrimal gland" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "lacrimal gland disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lacrimal gland disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: SCTID:95766002 {source="MONDO:equivalentTo"} +xref: UMLS:C0235228 {source="MONDO:equivalentTo"} +is_a: MONDO:0001854 {source="MONDO:Redundant"} ! lacrimal apparatus disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001817 ! lacrimal gland +relationship: disease_has_location UBERON:0001817 ! lacrimal gland +property_value: exactMatch http://identifiers.org/snomedct/95766002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0235228 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024627 +name: phagocytic cell dysfunction +synonym: "defective phagocytosis" EXACT [] +synonym: "phagocytic cell dysfunction" EXACT [] +xref: SCTID:302874002 {source="MONDO:equivalentTo"} +xref: UMLS:C0398732 {source="MONDO:equivalentTo"} +is_a: MONDO:0005046 {source="https://orcid.org/0000-0001-5208-3432"} ! immune system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0006909 ! phagocytosis +relationship: disease_disrupts GO:0006909 ! phagocytosis +relationship: disease_has_basis_in_dysfunction_of CL:0000234 ! phagocyte +property_value: exactMatch http://identifiers.org/snomedct/302874002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0398732 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0024630 +name: defective phagocytic cell chemotaxis +synonym: "defective phagocytic cell chemotaxis" EXACT [] +xref: ICD9:279.8 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:234580003 {source="MONDO:equivalentTo"} +xref: UMLS:C0398735 {source="MONDO:equivalentTo"} +is_a: MONDO:0024627 {source="MONDO:Redundant"} ! phagocytic cell dysfunction +intersection_of: MONDO:0024627 ! phagocytic cell dysfunction +intersection_of: disease_disrupts GO:0006935 ! chemotaxis +relationship: disease_disrupts GO:0006935 ! chemotaxis +property_value: exactMatch http://identifiers.org/snomedct/234580003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0398735 + +[Term] +id: MONDO:0024633 +name: hypertensive nephropathy +def: "Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria." [NCIT:C4757] +synonym: "HNP1" EXACT ABBREVIATION [MONDO:Lexical, OMIM:608026] +synonym: "hypertensive nephropathy" EXACT [MONDO:Lexical, NCIT:C4757, OMIM:608026] +synonym: "hypertensive renal disease" EXACT [] +xref: ICD9:403.90 {source="MONDO:equivalentTo", source="MONDO:i2s"} +xref: MESH:C563161 {source="MONDO:equivalentTo"} +xref: NCIT:C4757 {source="MONDO:equivalentTo"} +xref: OMIM:608026 {source="MONDO:equivalentTo"} +xref: SCTID:38481006 {source="MONDO:equivalentTo"} +xref: UMLS:C0848548 {source="MONDO:equivalentTo", source="MONDO:ncbi_mim2gene_medline", source="OMIM:608026"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0005240 ! kidney disorder +intersection_of: MONDO:0005240 ! kidney disorder +intersection_of: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +relationship: disease_arises_from_feature MONDO:0005044 ! hypertensive disorder +property_value: exactMatch http://identifiers.org/mesh/C563161 +property_value: exactMatch http://identifiers.org/snomedct/38481006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0848548 +property_value: exactMatch https://omim.org/entry/608026 +property_value: exactMatch NCIT:C4757 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3600 + +[Term] +id: MONDO:0024634 +name: large intestine disorder +def: "A disease that involves the large intestine." [MONDO:patterns/location] +synonym: "disease of large intestine" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of large intestine" EXACT [] +synonym: "disorder of large intestine" EXACT [MONDO:patterns/location_top] +synonym: "large intestine disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: SCTID:119523007 {source="MONDO:equivalentTo"} +xref: UMLS:C0341321 {source="MONDO:equivalentTo"} +is_a: MONDO:0005020 {source="MONDO:Redundant"} ! intestinal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000059 ! large intestine +relationship: disease_has_location UBERON:0000059 ! large intestine +property_value: exactMatch http://identifiers.org/snomedct/119523007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341321 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024635 +name: small intestine disorder +def: "A disease that involves the small intestine." [MONDO:patterns/location] +synonym: "disease of small intestine" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of small intestine" EXACT [] +synonym: "disorder of small intestine" EXACT [MONDO:patterns/location_top] +synonym: "small intestine disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: SCTID:119522002 {source="MONDO:equivalentTo"} +xref: UMLS:C0341268 {source="MONDO:equivalentTo"} +is_a: MONDO:0005020 {source="MONDO:Redundant"} ! intestinal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002108 ! small intestine +relationship: disease_has_location UBERON:0002108 ! small intestine +property_value: exactMatch http://identifiers.org/snomedct/119522002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0341268 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024636 +name: inflammation of heart layer +def: "An inflammatory disease involving a pathogenic inflammatory response in the heart layer." [MONDO:patterns/inflammatory_disease_by_site] +synonym: "carditis" EXACT [] +synonym: "heart layer inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: ICD9:429.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:399617002 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 {source="MONDO:Redundant"} ! heart disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0005983 ! heart layer +relationship: disease_has_inflammation_site UBERON:0005983 ! heart layer +property_value: exactMatch http://identifiers.org/snomedct/399617002 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0024642 +name: gastric neuroendocrine tumor G2 +def: "A well differentiated, intermediate grade tumor with neuroendocrine differentiation that arises from the stomach. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent." [NCIT:C95880] +synonym: "gastric NET G2" EXACT [NCIT:C95880] +synonym: "gastric neuroendocrine tumor G2" EXACT [NCIT:C95880] +xref: NCIT:C95880 {source="MONDO:equivalentTo"} +xref: UMLS:C3272407 {source="MONDO:equivalentTo", source="NCIT:C95880"} +is_a: MONDO:0015062 {source="NCIT:C95880"} ! gastric neuroendocrine tumor, well differentiated, low or intermediate grade +intersection_of: MONDO:0019496 {source="NCIT:C95880"} ! neuroendocrine neoplasm +intersection_of: disease_has_location UBERON:0000945 {source="NCIT:C95880"} ! stomach +intersection_of: has_modifier MONDO:0024492 {source="NCIT:C95880"} ! tumor grade 2, general grading system +relationship: has_modifier MONDO:0024492 ! tumor grade 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3272407 +property_value: exactMatch NCIT:C95880 + +[Term] +id: MONDO:0024643 +name: myocardial disorder +def: "A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy." [NCIT:C35544] +synonym: "disease of myocardium" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of myocardium" EXACT [] +synonym: "disorder of heart muscle" RELATED [] +synonym: "disorder of myocardium" EXACT [MONDO:patterns/location_top] +synonym: "myocardial disease" EXACT [] +synonym: "myocardial disorder" EXACT [NCIT:C35544] +synonym: "myocardium disease" EXACT [MONDO:design_pattern] +synonym: "myocardium disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: NCIT:C35544 {source="MONDO:equivalentTo"} +xref: SCTID:57809008 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 ! musculoskeletal system disorder +is_a: MONDO:0005267 {source="MONDO:Redundant", source="NCIT:C35544/inferred"} ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002349 ! myocardium +relationship: disease_has_location UBERON:0002349 ! myocardium +property_value: exactMatch http://identifiers.org/snomedct/57809008 +property_value: exactMatch NCIT:C35544 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024645 +name: retroperitoneal neoplasm +def: "A benign or malignant neoplasm that affects the retroperitoneum." [NCIT:C3357] +synonym: "neoplasm of retroperitoneal space" EXACT [MONDO:patterns/neoplasm] +synonym: "retroperitoneal neoplasm" EXACT [NCIT:C3357] +synonym: "retroperitoneal space neoplasm" EXACT [] +synonym: "retroperitoneal space tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of retroperitoneal space" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C3357 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003693 ! retroperitoneal space +relationship: disease_has_location UBERON:0003693 ! retroperitoneal space +property_value: exactMatch NCIT:C3357 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024648 +name: optic tract meningioma +def: "A meningioma that affects the visual pathway." [NCIT:C5587] +synonym: "meningioma (disease) of optic tract" EXACT [] +synonym: "meningioma of optic tract" EXACT [NCIT:C5587] +synonym: "meningioma of the optic tract" EXACT [NCIT:C5587] +synonym: "meningioma of the visual pathway" EXACT [NCIT:C5587] +synonym: "meningioma of visual pathway" EXACT [NCIT:C5587] +synonym: "optic tract meningioma" EXACT [NCIT:C5587] +synonym: "optic tract meningioma (disease)" EXACT [MONDO:patterns/location] +synonym: "visual pathway meningioma" EXACT [NCIT:C5587] +xref: NCIT:C5587 {source="MONDO:equivalentTo"} +xref: UMLS:C1336972 {source="MONDO:equivalentTo", source="NCIT:C5587"} +is_a: MONDO:0000642 ! brain meningioma +is_a: MONDO:0001834 ! visual pathway disorder +intersection_of: MONDO:0016642 ! meningioma +intersection_of: disease_has_location UBERON:0001908 ! optic tract +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336972 +property_value: exactMatch NCIT:C5587 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/meningioma.yaml + +[Term] +id: MONDO:0024649 +name: optic tract astrocytoma +def: "An astrocytoma that affects the optic tract. This condition can be seen in association with neurofibromatosis 1. It is most commonly seen in the pediatric age group." [NCIT:C7533] +synonym: "astrocytoma (excluding glioblastoma) of optic tract" EXACT [MONDO:design_pattern] +synonym: "optic tract astrocytoma" EXACT [NCIT:C7533] +synonym: "optic tract astrocytoma (excluding glioblastoma)" EXACT [MONDO:patterns/location] +synonym: "visual pathway astrocytoma" EXACT [NCIT:C7533] +xref: NCIT:C7533 {source="MONDO:equivalentTo"} +xref: UMLS:C1336971 {source="MONDO:equivalentTo", source="NCIT:C7533"} +is_a: MONDO:0000649 ! sensory system cancer +is_a: MONDO:0002109 ! pituitary cancer +is_a: MONDO:0003169 ! diencephalic astrocytomas +is_a: MONDO:0016167 {source="MONDO:Redundant", source="NCIT:C7533"} ! optic pathway glioma +intersection_of: MONDO:0019781 ! astrocytoma (excluding glioblastoma) +intersection_of: disease_has_location UBERON:0001908 ! optic tract +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336971 +property_value: exactMatch NCIT:C7533 + +[Term] +id: MONDO:0024653 +name: skull neoplasm +def: "A benign or malignant neoplasm that affects the bones and structures of the skull." [NCIT:C3375] +synonym: "neoplasm of skull" EXACT [MONDO:patterns/neoplasm, NCIT:C3375] +synonym: "neoplasm of the skull" EXACT [NCIT:C3375] +synonym: "skull neoplasm" EXACT [NCIT:C3375] +synonym: "skull tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3375] +synonym: "tumor of skull" EXACT [MONDO:patterns/neoplasm, NCIT:C3375] +synonym: "tumor of the skull" EXACT [NCIT:C3375] +xref: ICD9:239.2 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: MESH:D012888 {source="MONDO:equivalentTo"} +xref: NCIT:C3375 {source="MONDO:equivalentTo"} +xref: SCTID:126538005 {source="MONDO:equivalentTo"} +xref: UMLS:C0037305 {source="MONDO:equivalentTo", source="NCIT:C3375"} +is_a: MONDO:0005586 {source="MONDO:Redundant", source="NCIT:C3375"} ! head and neck neoplasm +is_a: MONDO:0019060 ! bone neoplasm +is_a: MONDO:0024654 ! skull disorder +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003129 ! skull +property_value: exactMatch http://identifiers.org/mesh/D012888 +property_value: exactMatch http://identifiers.org/snomedct/126538005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0037305 +property_value: exactMatch NCIT:C3375 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024654 +name: skull disorder +def: "A non-neoplastic or neoplastic disorder that affects structures of the skull." [NCIT:C27655] +synonym: "disease of skull" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of skull" EXACT [] +synonym: "disorder of skull" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "skull disease" EXACT [NCIT:C27655] +synonym: "skull disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "skull disorder" EXACT [NCIT:C27655] +xref: NCIT:C27655 {source="MONDO:equivalentTo"} +xref: SCTID:118945008 {source="MONDO:equivalentTo"} +xref: UMLS:C1290854 {source="MONDO:equivalentTo", source="NCIT:C27655"} +is_a: MONDO:0005042 ! head disorder +is_a: MONDO:0005381 ! bone disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0003129 ! skull +relationship: disease_has_location UBERON:0003129 ! skull +property_value: exactMatch http://identifiers.org/snomedct/118945008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290854 +property_value: exactMatch NCIT:C27655 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024655 +name: rheumatic pericarditis +synonym: "rheumatic pericarditis" EXACT [] +xref: SCTID:28381002 {source="MONDO:equivalentTo"} +xref: UMLS:C0264747 {source="MONDO:equivalentTo"} +is_a: MONDO:0005904 {source="MONDO:Redundant"} ! pericarditis +is_a: MONDO:0006955 {source="MONDO:Redundant"} ! rheumatic heart disease +intersection_of: MONDO:0006955 ! rheumatic heart disease +intersection_of: disease_has_inflammation_site UBERON:0002407 ! pericardium +property_value: exactMatch http://identifiers.org/snomedct/28381002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264747 + +[Term] +id: MONDO:0024656 +name: colorectal lymphoma +def: "An extranodal lymphoma that arises from the colon or rectum. The majority are B-cell non-Hodgkin lymphomas." [NCIT:C96498] +synonym: "colorectal lymphoma" EXACT [NCIT:C96498] +synonym: "large intestinal lymphoma" EXACT [NCIT:C96498] +synonym: "large intestine lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "lymphoma of large intestine" EXACT [MONDO:design_pattern] +synonym: "primary colorectal lymphoma" EXACT [NCIT:C96498] +xref: NCIT:C96498 {source="MONDO:equivalentTo"} +xref: UMLS:C3272822 {source="MONDO:equivalentTo", source="NCIT:C96498"} +is_a: MONDO:0004699 {source="MONDO:Redundant", source="NCIT:C96498"} ! gastrointestinal lymphoma +is_a: MONDO:0005575 {source="NCIT:C96498"} ! colorectal cancer +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0000059 ! large intestine +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3272822 +property_value: exactMatch NCIT:C96498 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0024664 +name: hypertension, pregnancy-induced +def: "A hypertensive disorder that develops during pregnancy." [NCIT:C9243] +synonym: "gestational hypertension" RELATED [MESH:D046110] +synonym: "hypertension associated disorders of pregnancy" EXACT [NCIT:C9243] +synonym: "hypertension complicating pregnancy" RELATED [] +synonym: "hypertension induced by pregnancy" RELATED [] +synonym: "hypertension, gestational" RELATED [MESH:D046110] +synonym: "hypertension, pregnancy induced" RELATED [MESH:D046110] +synonym: "hypertension, pregnancy transient" RELATED [MESH:D046110] +synonym: "hypertension-associated pregnancy disorder" EXACT [NCIT:C9243] +synonym: "hypertensions, pregnancy induced" RELATED [MESH:D046110] +synonym: "induced hypertension, pregnancy" RELATED [MESH:D046110] +synonym: "induced Hypertensions, pregnancy" RELATED [MESH:D046110] +synonym: "pregnancy induced hypertension" RELATED [MESH:D046110] +synonym: "pregnancy transient hypertension" RELATED [MESH:D046110] +synonym: "pregnancy-induced hypertension" EXACT [MESH:D046110] +synonym: "transient hypertension, pregnancy" RELATED [MESH:D046110] +xref: MESH:D046110 {source="MONDO:equivalentTo"} +xref: NCIT:C9243 {source="MONDO:equivalentTo"} +xref: SCTID:48194001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005044 {source="MESH:D046110", source="MONDO:Redundant"} ! hypertensive disorder +is_a: MONDO:0024575 {source="MESH:D046110", source="MONDO:Redundant", source="NCIT:C9243"} ! pregnancy disorder +intersection_of: MONDO:0005044 ! hypertensive disorder +intersection_of: MONDO:0024575 ! pregnancy disorder +property_value: exactMatch http://identifiers.org/mesh/D046110 +property_value: exactMatch http://identifiers.org/snomedct/48194001 +property_value: exactMatch NCIT:C9243 + +[Term] +id: MONDO:0024666 +name: benign epithelial skin neoplasm +def: "A form of epithelial skin neoplasm without malignant characteristics." [MONDO:patterns/benign] +synonym: "benign epithelial skin neoplasm" EXACT [NCIT:C7341] +synonym: "benign epithelial skin tumor" EXACT [NCIT:C7341] +synonym: "benign skin epithelium neoplasm" EXACT [NCIT:C7341] +synonym: "benign skin epithelium tumor" EXACT [NCIT:C7341] +synonym: "epithelial skin neoplasm, benign" EXACT [MONDO:patterns/benign] +xref: NCIT:C7341 {source="MONDO:equivalentTo"} +xref: UMLS:C0345981 {source="NCIT:C7341", source="MONDO:equivalentTo"} +is_a: MONDO:0021440 {source="MONDO:Redundant", source="NCIT:C7341"} ! benign neoplasm of skin +is_a: MONDO:0021634 {source="MONDO:Redundant", source="NCIT:C7341"} ! epithelial skin neoplasm +is_a: MONDO:0036976 ! benign epithelial neoplasm +intersection_of: MONDO:0021634 ! epithelial skin neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0345981 +property_value: exactMatch NCIT:C7341 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0024744 +name: childhood choroid plexus neoplasm +def: "A neoplasm that arises from the choroid plexus in the brain and occurs during childhood." [NCIT:C42080] +synonym: "childhood choroid plexus neoplasm" EXACT [NCIT:C42080] +synonym: "choroid plexus neoplasm" BROAD [NCIT:C42080] +synonym: "choroid plexus neoplasm of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric choroid plexus neoplasm" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: NCIT:C42080 {source="MONDO:equivalentTo"} +is_a: MONDO:0016717 {source="MONDO:Redundant", source="NCIT:C42080"} ! choroid plexus neoplasm +is_a: MONDO:0021079 ! childhood neoplasm +intersection_of: MONDO:0016717 ! choroid plexus neoplasm +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch NCIT:C42080 + +[Term] +id: MONDO:0024757 +name: cardiovascular neoplasm +def: "A benign or malignant neoplasm that affects the heart and/or vessels. Representative examples of benign neoplasms include atrial myxoma, hemangioma, and lymphangioma. Representative examples of malignant neoplasms include pericardial malignant mesothelioma and angiosarcoma." [NCIT:C4784] +synonym: "cardiovascular neoplasm" EXACT [NCIT:C4784] +synonym: "cardiovascular system neoplasm" EXACT [] +synonym: "cardiovascular system tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "cardiovascular tumor" EXACT [NCIT:C4784] +synonym: "neoplasm of cardiovascular system" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of cardiovascular system" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C4784 {source="MONDO:equivalentTo"} +xref: SCTID:721573003 {source="MONDO:equivalentTo"} +is_a: MONDO:0004995 {source="MONDO:Redundant", source="NCIT:C4784"} ! cardiovascular disorder +is_a: MONDO:0005070 ! neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0004535 ! cardiovascular system +property_value: exactMatch http://identifiers.org/snomedct/721573003 +property_value: exactMatch NCIT:C4784 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024873 +name: clitoral carcinoma +def: "A carcinoma that arises from the clitoris." [NCIT:C9362] +synonym: "carcinoma of clitoris" EXACT [MONDO:patterns/carcinoma, NCIT:C9362] +synonym: "carcinoma of the clitoris" EXACT [NCIT:C9362] +synonym: "clitoral cancer" BROAD [NCIT:C9362] +synonym: "clitoral carcinoma" EXACT [NCIT:C9362] +synonym: "clitoris carcinoma" EXACT [NCIT:C9362] +xref: NCIT:C9362 {source="MONDO:equivalentTo"} +xref: UMLS:C1333070 {source="MONDO:equivalentTo", source="NCIT:C9362"} +is_a: MONDO:0002290 {source="MONDO:Redundant", source="NCIT:C9362"} ! clitoris cancer +is_a: MONDO:0005215 {source="MONDO:Redundant", source="NCIT:C9362"} ! vulvar carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0002411 ! clitoris +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333070 +property_value: exactMatch NCIT:C9362 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0024876 +name: tendon sheath disorder +def: "A disease that involves the tendon sheath." [MONDO:patterns/location] +synonym: "disease of tendon sheath" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of tendon sheath" EXACT [] +synonym: "disorder of tendon sheath" EXACT [MONDO:patterns/location_top] +synonym: "tendon sheath disease" EXACT [] +synonym: "tendon sheath disease or disorder" EXACT [MONDO:patterns/location] +synonym: "tendon sheath disorder" EXACT [] +xref: ICD9:727.9 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:312381009 {source="MONDO:equivalentTo"} +xref: UMLS:C0729734 {source="MONDO:equivalentTo"} +is_a: MONDO:0100010 ! tendinopathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000304 ! tendon sheath +relationship: disease_has_location UBERON:0000304 ! tendon sheath +property_value: exactMatch http://identifiers.org/snomedct/312381009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0729734 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0024877 +name: clitoris neoplasm +def: "A neoplasm involving a clitoris." [MONDO:patterns/neoplasm] +synonym: "clitoral neoplasm" EXACT [] +synonym: "clitoris tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "neoplasm of clitoris" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of clitoris" EXACT [MONDO:patterns/neoplasm] +xref: ICD9:239.5 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: SCTID:126925009 {source="MONDO:equivalentTo"} +xref: UMLS:C1263793 {source="MONDO:equivalentTo"} +is_a: MONDO:0021049 {source="MONDO:Redundant"} ! vulvar neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002411 ! clitoris +relationship: disease_has_location UBERON:0002411 ! clitoris +property_value: exactMatch http://identifiers.org/snomedct/126925009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263793 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024878 +name: secondary carcinoma +def: "A carcinoma that arises from a pre-existing lower grade epithelial lesion, or as a result of a primary carcinoma that has spread to secondary sites, or due to a complication of a cancer treatment." [NCIT:C36310] +comment: Note that we currently treat secondary neoplasms as being neoplastic diseases that are derived from neoplasm; classes such as 'neoplasm', 'carcinoma' are implicitly primary. This may change in future. +synonym: "secondary carcinoma" EXACT [NCIT:C36310] +xref: NCIT:C36310 {source="MONDO:equivalentTo"} +xref: UMLS:C0085668 {source="NCIT:C36310", source="MONDO:equivalentTo"} +is_a: MONDO:0004993 ! carcinoma +is_a: MONDO:0024881 {source="NCIT:C36310"} ! secondary malignant neoplasm +intersection_of: MONDO:0024882 ! secondary neoplasm +intersection_of: disease_arises_from_feature MONDO:0004993 ! carcinoma +relationship: disease_arises_from_feature MONDO:0004993 ! carcinoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0085668 +property_value: exactMatch NCIT:C36310 +property_value: excluded_subClassOf MONDO:0004993 {source="NCIT:C36310"} + +[Term] +id: MONDO:0024881 +name: secondary malignant neoplasm +def: "A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment." [NCIT:C4968] +comment: Note that we currently treat secondary neoplasms as being neoplastic diseases that are derived from neoplasm; classes such as 'neoplasm', 'carcinoma' are implicitly primary. This may change in future. +synonym: "secondary cancer" EXACT [NCIT:C4968] +synonym: "secondary malignancy" EXACT [NCIT:C4968] +synonym: "secondary malignant neoplasm" EXACT [NCIT:C4968] +xref: ICD9:198.89 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: ICD9:199.1 {source="MONDO:relatedTo", source="MONDO:i2s"} +xref: NCIT:C4968 {source="MONDO:equivalentTo"} +xref: SCTID:128462008 {source="MONDO:equivalentTo"} +is_a: MONDO:0004992 {source="NCIT:C4968"} ! cancer +is_a: MONDO:0024882 {source="NCIT:C4968"} ! secondary neoplasm +property_value: exactMatch http://identifiers.org/snomedct/128462008 +property_value: exactMatch NCIT:C4968 + +[Term] +id: MONDO:0024882 +name: secondary neoplasm +def: "A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment." [NCIT:C36255] +comment: Note that we currently treat secondary neoplasms as being neoplastic diseases that are derived from neoplasm; classes such as 'neoplasm', 'carcinoma' are implicitly primary. This may change in future. +synonym: "secondary neoplasm" EXACT [NCIT:C36255] +synonym: "secondary tumor" EXACT [NCIT:C36255] +xref: NCIT:C36255 {source="MONDO:equivalentTo"} +is_a: MONDO:0023370 ! neoplastic disease or syndrome +intersection_of: MONDO:0023370 ! neoplastic disease or syndrome +intersection_of: disease_arises_from_feature MONDO:0005070 ! neoplasm +relationship: disease_arises_from_feature MONDO:0005070 ! neoplasm +property_value: exactMatch NCIT:C36255 + +[Term] +id: MONDO:0024888 +name: mesonephric neoplasm +def: "An epithelial neoplasm of the female reproductive system arising from mesonephric remnants." [NCIT:C4295] +synonym: "mesonephric duct neoplasm" EXACT [] +synonym: "mesonephric duct tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "mesonephric neoplasm" EXACT [NCIT:C4295] +synonym: "mesonephric tumor" EXACT [NCIT:C4295] +synonym: "mesonephroma" EXACT [NCIT:C4295] +synonym: "neoplasm of mesonephric duct" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of mesonephric duct" EXACT [MONDO:patterns/neoplasm] +synonym: "Wolffian duct neoplasm" EXACT [NCIT:C4295] +synonym: "Wolffian duct tumor" EXACT [NCIT:C4295] +xref: ICDO:9110/1 {source="NCIT:C4295"} +xref: NCIT:C4295 {source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="NCIT:C4295"} ! epithelial neoplasm +is_a: MONDO:0021163 ! kidney neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0003074 ! mesonephric duct +relationship: disease_has_location UBERON:0003074 ! mesonephric duct +property_value: exactMatch NCIT:C4295 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0024889 +name: benign mesonephroma +def: "A benign epithelial neoplasm of the female reproductive system arising from mesonephric remnants." [NCIT:C4294] +synonym: "benign mesonephric neoplasm" EXACT [] +synonym: "benign Mesonephroma" EXACT [NCIT:C4294] +synonym: "mesonephric adenoma" EXACT [DOID:2616, NCIT:C4294] +synonym: "mesonephric duct adenoma" EXACT [MONDO:patterns/location] +synonym: "mesonephric neoplasm, benign" EXACT [MONDO:patterns/benign] +synonym: "Mesonephroma, benign" EXACT [DOID:2616] +synonym: "Mesonephroma, benign (morphologic abnormality)" EXACT [DOID:2616] +synonym: "Wolffian duct adenoma" EXACT [DOID:2616, NCIT:C4294] +xref: DOID:2616 {source="MONDO:equivalentTo"} +xref: ICDO:9110/0 {source="NCIT:C4294"} +xref: NCIT:C4294 {source="MONDO:equivalentTo", source="DOID:2616"} +xref: UMLS:C0334530 {source="NCIT:C4294", source="MONDO:equivalentTo", source="DOID:2616"} +is_a: MONDO:0002513 ! kidney benign neoplasm +is_a: MONDO:0024888 {source="MONDO:Redundant", source="NCIT:C4294"} ! mesonephric neoplasm +is_a: MONDO:0036976 ! benign epithelial neoplasm +intersection_of: MONDO:0024888 ! mesonephric neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch DOID:2616 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334530 +property_value: exactMatch NCIT:C4294 +property_value: excluded_subClassOf MONDO:0000383 {source="DOID:2616"} +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0024988 +name: sex cord-stromal benign neoplasm +def: "A reproductive organ benign neoplasm that arises in the ovary or testis and that is composed of granulosa cells, Leydig cells, Sertoli cells, and/or fibroblasts." [DOID:0080368] +xref: DOID:0080368 {source="MONDO:equivalentTo"} +is_a: MONDO:0000383 {source="DOID:0080368"} ! benign reproductive system neoplasm +is_a: MONDO:0006055 ! sex cord-stromal tumor +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0005295 ! sex cord +property_value: exactMatch DOID:0080368 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0025511 +name: inherited neuroendocrine tumor +def: "An instance of neuroendocrine neoplasm that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "genetic neuroendocrine tumor" RELATED [Orphanet:271847] +synonym: "hereditary neuroendocrine neoplasm" EXACT [MONDO:patterns/hereditary] +xref: Orphanet:271847 {source="MONDO:equivalentTo"} +xref: UMLS:CN202530 {source="MONDO:equivalentTo"} +is_a: MONDO:0003847 ! Mendelian disease +is_a: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: MONDO:0019496 ! neuroendocrine neoplasm +intersection_of: has_modifier MONDO:0021152 ! inherited +relationship: has_modifier MONDO:0021136 {source="MONDO:0019041"} ! rare +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN202530 +property_value: exactMatch Orphanet:271847 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/hereditary.yaml + +[Term] +id: MONDO:0025512 +name: type II hypersensitivity reaction disease +def: "A disease that has its basis in the disruption of type II hypersensitivity." [MONDO:patterns/basis_in_disruption_of_process] +comment: Note that DO combines autoimmune and type II hypersensitivity in one concept (2018-06-22) +synonym: "disorder of type II hypersensitivity" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "type II hypersensitivity disease" EXACT [MONDO:design_pattern] +xref: EFO:0005809 {source="MONDO:equivalentTo"} +is_a: MONDO:0000605 {source="EFO:0005809", source="MONDO:indirect"} ! hypersensitivity reaction disease +is_a: MONDO:0007179 ! autoimmune disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0002445 ! type II hypersensitivity +relationship: disease_has_basis_in_disruption_of GO:0002445 ! type II hypersensitivity +property_value: excluded_subClassOf MONDO:0005046 {source="EFO:0005809"} +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0030700 +name: autoimmune glomerulonephritis +def: "An autoimmune form of glomerulonephritis (disease)." [MONDO:patterns/autoimmune] +synonym: "autoimmune glomerulonephritis (disease)" EXACT [] +xref: DOID:0040094 {source="MONDO:equivalentTo"} +is_a: MONDO:0000601 {source="DOID:0040094"} ! autoimmune disorder of urogenital tract +is_a: MONDO:0002462 ! glomerulonephritis +intersection_of: MONDO:0002462 ! glomerulonephritis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040094 + +[Term] +id: MONDO:0030701 +name: autoimmune cardiomyopathy +def: "An autoimmune form of cardiomyopathy." [MONDO:patterns/autoimmune] +xref: DOID:0040095 {source="MONDO:equivalentTo"} +is_a: MONDO:0000589 ! autoimmune disorder of musculoskeletal system +is_a: MONDO:0000603 {source="DOID:0040095", source="MONDO:Redundant"} ! autoimmune disorder of cardiovascular system +is_a: MONDO:0004994 ! cardiomyopathy +intersection_of: MONDO:0004994 ! cardiomyopathy +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040095 + +[Term] +id: MONDO:0030702 +name: autoimmune atherosclerosis +def: "An autoimmune form of atherosclerosis." [MONDO:patterns/autoimmune] +xref: DOID:0040096 {source="MONDO:equivalentTo"} +is_a: MONDO:0000603 {source="DOID:0040096", source="MONDO:Redundant"} ! autoimmune disorder of cardiovascular system +is_a: MONDO:0005311 ! atherosclerosis +intersection_of: MONDO:0005311 ! atherosclerosis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040096 + +[Term] +id: MONDO:0030703 +name: autoimmune vasculitis +def: "An autoimmune form of vasculitis." [MONDO:patterns/autoimmune] +xref: DOID:0040097 {source="MONDO:equivalentTo"} +xref: SCTID:427213005 {source="MONDO:equivalentTo"} +xref: UMLS:C1328843 {source="MONDO:equivalentTo", source="DOID:0040097"} +is_a: MONDO:0000603 {source="DOID:0040097", source="MONDO:Redundant"} ! autoimmune disorder of cardiovascular system +is_a: MONDO:0018882 ! vasculitis +intersection_of: MONDO:0018882 ! vasculitis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040097 +property_value: exactMatch http://identifiers.org/snomedct/427213005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1328843 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0031012 +name: autoimmune uveitis +def: "An autoimmune form of uveitis (disease)." [MONDO:patterns/autoimmune] +synonym: "autoimmune uveitis (disease)" EXACT [] +xref: DOID:0040088 {source="MONDO:equivalentTo"} +is_a: MONDO:0000587 {source="DOID:0040088"} ! autoimmune disease of ear, nose and throat +is_a: MONDO:0020283 ! uveitis +intersection_of: MONDO:0020283 ! uveitis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040088 + +[Term] +id: MONDO:0031013 +name: autoimmune optic neuritis +def: "An autoimmune form of optic neuritis." [MONDO:patterns/autoimmune] +xref: DOID:0040089 {source="MONDO:equivalentTo"} +is_a: MONDO:0000568 ! autoimmune disorder of central nervous system +is_a: MONDO:0000590 {source="DOID:0040089"} ! autoimmune disorder of peripheral nervous system +is_a: MONDO:0005885 ! optic neuritis +intersection_of: MONDO:0005885 ! optic neuritis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040089 + +[Term] +id: MONDO:0031014 +name: autoimmune gastritis +def: "Inflammation of the body fundic mucosa of the stomach. It results from the development of autoantibodies against the parietal and chief cells. It is associated with the presence of intestinal metaplasia and an increased risk of developing gastric carcinoma." [NCIT:C95752] +synonym: "autoimmune gastritis (disease)" EXACT [] +xref: DOID:0040090 {source="MONDO:equivalentTo"} +xref: NCIT:C95752 {source="MONDO:equivalentTo"} +is_a: MONDO:0000588 {source="DOID:0040090", source="MONDO:Redundant"} ! autoimmune disorder of gastrointestinal tract +is_a: MONDO:0004966 ! gastritis +intersection_of: MONDO:0004966 ! gastritis +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch DOID:0040090 +property_value: exactMatch NCIT:C95752 + +[Term] +id: MONDO:0036511 +name: childhood malignant kidney neoplasm +def: "A malignant neoplasm that affects the kidney and occurs in childhood." [NCIT:C123907] +synonym: "childhood kidney cancer" EXACT [MONDO:design_pattern] +synonym: "childhood malignant kidney neoplasm" EXACT [NCIT:C123907] +synonym: "childhood malignant kidney tumor" EXACT [NCIT:C123907] +synonym: "childhood malignant renal neoplasm" EXACT [NCIT:C123907] +synonym: "childhood malignant renal tumor" EXACT [NCIT:C123907] +synonym: "kidney cancer of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric kidney cancer" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +xref: NCIT:C123907 {source="MONDO:equivalentTo"} +xref: UMLS:C4086162 {source="MONDO:equivalentTo", source="NCIT:C123907"} +is_a: MONDO:0002367 {source="MONDO:Redundant", source="NCIT:C123907"} ! kidney cancer +is_a: MONDO:0002730 {source="MONDO:Redundant", source="NCIT:C123907"} ! childhood kidney neoplasm +is_a: MONDO:0006517 {source="MONDO:Redundant", source="NCIT:C123907"} ! childhood malignant neoplasm +intersection_of: MONDO:0002367 ! kidney cancer +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4086162 +property_value: exactMatch NCIT:C123907 + +[Term] +id: MONDO:0036591 +name: adrenal cortex neoplasm +def: "A benign or malignant (primary or metastatic) neoplasm affecting the adrenal cortex. (NCI05)" [NCIT:C2858] +synonym: "adrenal cortex neoplasm" EXACT [NCIT:C2858] +synonym: "adrenal cortex tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C2858] +synonym: "adrenocortical neoplasm" EXACT [NCIT:C2858] +synonym: "adrenocortical tumor" EXACT [NCIT:C2858] +synonym: "neoplasm of adrenal cortex" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of adrenal cortex" EXACT [MONDO:patterns/neoplasm] +xref: MESH:D000306 {source="MONDO:equivalentTo"} +xref: NCIT:C2858 {source="MONDO:equivalentTo"} +is_a: MONDO:0002816 ! adrenal cortex disorder +is_a: MONDO:0021227 ! adrenal gland neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001235 ! adrenal cortex +property_value: exactMatch http://identifiers.org/mesh/D000306 +property_value: exactMatch NCIT:C2858 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0036696 +name: spleen neoplasm +def: "A benign or malignant neoplasm that affects the spleen. Representative examples include hemangioma, lymphoma, splenic involvement by leukemia, and angiosarcoma." [NCIT:C3383] +synonym: "neoplasm of spleen" EXACT [MONDO:patterns/neoplasm] +synonym: "spleen tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "splenic neoplasm" EXACT [NCIT:C3383] +synonym: "tumor of spleen" EXACT [MONDO:patterns/neoplasm] +xref: GARD:0007683 {source="MONDO:equivalentTo"} +xref: NCIT:C3383 {source="MONDO:equivalentTo"} +is_a: MONDO:0002332 ! splenic disorder +is_a: MONDO:0002334 {source="MONDO:Redundant", source="NCIT:C3383"} ! hematopoietic and lymphoid system neoplasm +is_a: MONDO:0021223 ! digestive system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0002106 ! spleen +property_value: exactMatch NCIT:C3383 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0036779 +name: axillary neoplasm +def: "A benign or malignant neoplasm that affects the structures of the axilla. Representative examples include axillary lipoma, axillary lymph node lymphoma, and metastatic carcinoma to the axillary lymph nodes." [NCIT:C35749] +synonym: "axilla neoplasm" EXACT [] +synonym: "axilla tumor" EXACT [MONDO:patterns/neoplasm] +synonym: "axillary neoplasm" EXACT [NCIT:C35749] +synonym: "neoplasm of axilla" EXACT [MONDO:patterns/neoplasm] +synonym: "tumor of axilla" EXACT [MONDO:patterns/neoplasm] +xref: NCIT:C35749 {source="MONDO:equivalentTo"} +xref: SCTID:126639006 {source="MONDO:equivalentTo"} +xref: UMLS:C1290308 {source="NCIT:C35749", source="MONDO:equivalentTo"} +is_a: MONDO:0021350 {source="NCIT:C35749"} ! neoplasm of thorax +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0009472 ! axilla +relationship: disease_has_location UBERON:0009472 ! axilla +property_value: exactMatch http://identifiers.org/snomedct/126639006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290308 +property_value: exactMatch NCIT:C35749 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0036781 +name: benign axillary neoplasm +def: "A non-metastasizing neoplasm that arises from the structures of the axilla." [NCIT:C35750] +synonym: "axillary neoplasm, benign" EXACT [MONDO:patterns/benign] +synonym: "benign axillary neoplasm" EXACT [NCIT:C35750] +xref: NCIT:C35750 {source="MONDO:equivalentTo"} +xref: UMLS:C0684828 {source="MONDO:equivalentTo", source="NCIT:C35750"} +is_a: MONDO:0000634 {source="MONDO:Redundant", source="NCIT:C35750"} ! thoracic benign neoplasm +is_a: MONDO:0036779 {source="MONDO:Redundant", source="NCIT:C35750"} ! axillary neoplasm +intersection_of: MONDO:0036779 ! axillary neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0684828 +property_value: exactMatch NCIT:C35750 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0036870 +name: lymphatic vessel neoplasm +def: "A benign or malignant neoplasm arising from the lymphatic vessels." [NCIT:C3723] +synonym: "lymph vessel neoplasm" EXACT [NCIT:C3723] +synonym: "lymph vessel tumor" EXACT [NCIT:C3723] +synonym: "lymphatic vessel neoplasm" EXACT [NCIT:C3723] +synonym: "lymphatic vessel tumor" EXACT [MONDO:patterns/neoplasm, NCIT:C3723] +synonym: "neoplasm of lymph vessel" EXACT [NCIT:C3723] +synonym: "neoplasm of lymphatic vessel" EXACT [MONDO:patterns/neoplasm, NCIT:C3723] +synonym: "neoplasm of the lymph vessel" EXACT [NCIT:C3723] +synonym: "neoplasm of the lymphatic vessel" EXACT [NCIT:C3723] +synonym: "tumor of lymph vessel" EXACT [NCIT:C3723] +synonym: "tumor of lymphatic vessel" EXACT [MONDO:patterns/neoplasm, NCIT:C3723] +synonym: "tumor of the lymph vessel" EXACT [NCIT:C3723] +synonym: "tumor of the lymphatic vessel" EXACT [NCIT:C3723] +xref: NCIT:C3723 {source="MONDO:equivalentTo"} +xref: UMLS:C0206619 {source="MONDO:equivalentTo", source="NCIT:C3723"} +is_a: MONDO:0005385 ! vascular disorder +is_a: MONDO:0005833 ! lymphatic system disorder +is_a: MONDO:0024296 {source="MONDO:Redundant", source="NCIT:C3723"} ! vascular neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0001473 ! lymphatic vessel +relationship: disease_has_location UBERON:0001473 ! lymphatic vessel +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0206619 +property_value: exactMatch NCIT:C3723 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/neoplasm.yaml + +[Term] +id: MONDO:0036976 +name: benign epithelial neoplasm +def: "A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites." [NCIT:C4092] +synonym: "benign epithelial neoplasm" EXACT [NCIT:C4092] +synonym: "benign epithelial tumor" EXACT [NCIT:C4092] +synonym: "benign epithelioma" EXACT [NCIT:C4092] +synonym: "benign neoplasm of epithelium" EXACT [NCIT:C4092] +synonym: "benign neoplasm of the epithelium" EXACT [NCIT:C4092] +synonym: "benign tumor of epithelium" EXACT [NCIT:C4092] +synonym: "benign tumor of the epithelium" EXACT [NCIT:C4092] +synonym: "epithelial neoplasm, benign" EXACT [MONDO:patterns/benign] +synonym: "epithelioma, benign" EXACT [NCIT:C4092] +xref: ICDO:8010/0 {source="NCIT:C4092"} +xref: ICDO:8011/0 {source="NCIT:C4092"} +xref: NCIT:C4092 {source="MONDO:equivalentTo"} +xref: UMLS:C0334232 {source="MONDO:equivalentTo", source="NCIT:C4092"} +is_a: MONDO:0005165 ! benign neoplasm +is_a: MONDO:0005626 {source="MONDO:Redundant", source="NCIT:C4092"} ! epithelial neoplasm +intersection_of: MONDO:0005626 ! epithelial neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334232 +property_value: exactMatch NCIT:C4092 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0037105 +name: lung germ cell tumor +def: "A germ cell tumor that arises from the lung." [NCIT:C45636] +synonym: "lung germ cell neoplasm" EXACT [NCIT:C45636] +synonym: "lung germ cell tumor" EXACT [NCIT:C45636] +xref: NCIT:C45636 {source="MONDO:equivalentTo"} +xref: UMLS:C1708771 {source="MONDO:equivalentTo", source="NCIT:C45636"} +is_a: MONDO:0018201 {source="NCIT:C45636"} ! extragonadal germ cell tumor +is_a: MONDO:0021117 {source="MONDO:Redundant", source="NCIT:C45636"} ! lung neoplasm +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0002048 ! lung +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1708771 +property_value: exactMatch NCIT:C45636 + +[Term] +id: MONDO:0037250 +name: childhood testicular neoplasm +def: "A neoplasm that arises from the testis during childhood." [NCIT:C5053] +synonym: "childhood neoplasm of testis" EXACT [NCIT:C5053] +synonym: "childhood neoplasm of the testis" EXACT [NCIT:C5053] +synonym: "childhood testicular neoplasm" EXACT [NCIT:C5053] +synonym: "neoplasm of testis of childhood" EXACT [MONDO:design_pattern, MONDO:patterns/childhood] +synonym: "pediatric neoplasm of testis" EXACT [MONDO:patterns/childhood, NCIT:C5053] +synonym: "pediatric neoplasm of the testis" EXACT [NCIT:C5053] +synonym: "pediatric testicular neoplasm" EXACT [NCIT:C5053] +synonym: "testicular tumor, childhood" EXACT [NCIT:C5053] +xref: NCIT:C5053 {source="MONDO:equivalentTo"} +is_a: MONDO:0021079 {source="MONDO:Redundant", source="NCIT:C5053"} ! childhood neoplasm +is_a: MONDO:0021348 {source="MONDO:Redundant", source="NCIT:C5053"} ! neoplasm of testis +intersection_of: MONDO:0021348 ! neoplasm of testis +intersection_of: has_modifier HP:0011463 ! Childhood onset +property_value: exactMatch NCIT:C5053 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/childhood.yaml + +[Term] +id: MONDO:0037254 +name: transitional cell neoplasm +synonym: "transitional cell neoplasm" EXACT [NCIT:C6783] +synonym: "transitional cell tumor" EXACT [NCIT:C6783] +xref: NCIT:C6783 {source="MONDO:equivalentTo"} +xref: UMLS:C0334265 {source="NCIT:C6783", source="MONDO:equivalentTo"} +is_a: MONDO:0005626 {source="NCIT:C6783"} ! epithelial neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0334265 +property_value: exactMatch NCIT:C6783 + +[Term] +id: MONDO:0037735 +name: sebaceous gland cancer +def: "A cancer that involves the sebaceous gland." [MONDO:patterns/location] +synonym: "cancer of sebaceous gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of sebaceous gland" EXACT [MONDO:patterns/cancer, NCIT:C8409] +synonym: "malignant neoplasm of the sebaceous gland" EXACT [NCIT:C8409] +synonym: "malignant sebaceous gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C8409] +synonym: "malignant sebaceous gland tumor" EXACT [NCIT:C8409] +synonym: "malignant sebaceous neoplasm" EXACT [NCIT:C8409] +synonym: "malignant sebaceous tumor" EXACT [NCIT:C8409] +synonym: "malignant tumor of sebaceous gland" EXACT [NCIT:C8409] +synonym: "malignant tumor of the sebaceous gland" EXACT [NCIT:C8409] +xref: NCIT:C8409 {source="MONDO:equivalentTo"} +xref: UMLS:C1382026 {source="MONDO:equivalentTo", source="NCIT:C8409"} +is_a: MONDO:0002898 ! skin cancer +is_a: MONDO:0006963 {source="MONDO:Redundant", source="NCIT:C8409"} ! sebaceous gland neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001821 ! sebaceous gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1382026 +property_value: exactMatch NCIT:C8409 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0037736 +name: infratentorial neoplasm +def: "A benign or malignant neoplasm that occurs in brain parenchymal tissue below the tentorium cerebelli." [NCIT:C3139] +synonym: "brain neoplasms, infratentorial" EXACT [NCIT:C3139] +synonym: "infratentorial neoplasm" EXACT [NCIT:C3139] +synonym: "infratentorial neoplasms" EXACT [NCIT:C3139] +synonym: "infratentorial tumor" EXACT [NCIT:C3139] +synonym: "infratentorial tumors" EXACT [NCIT:C3139] +synonym: "neoplasms, infratentorial" EXACT [NCIT:C3139] +xref: NCIT:C3139 {source="MONDO:equivalentTo"} +is_a: MONDO:0021211 {source="NCIT:C3139"} ! brain neoplasm +property_value: exactMatch NCIT:C3139 + +[Term] +id: MONDO:0037792 +name: carbohydrate metabolism disease +def: "A disease that has its basis in the disruption of carbohydrate metabolic process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "carbohydrate metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "disorder of carbohydrate metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of carbohydrate metabolism" EXACT [] +xref: SCTID:20957000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0005975 ! carbohydrate metabolic process +relationship: disease_has_basis_in_disruption_of GO:0005975 ! carbohydrate metabolic process +property_value: exactMatch http://identifiers.org/snomedct/20957000 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0037829 +name: purine metabolism disease +def: "A disease that has its basis in the disruption of purine nucleobase metabolic process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of purine metabolism" EXACT [] +synonym: "disorder of purine nucleobase metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "purine nucleobase metabolic process disease" EXACT [MONDO:design_pattern] +xref: SCTID:32612005 {source="MONDO:equivalentTo"} +xref: UMLS:C0268104 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="https://orcid.org/0000-0001-5208-3432"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006144 ! purine nucleobase metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006144 ! purine nucleobase metabolic process +property_value: exactMatch http://identifiers.org/snomedct/32612005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268104 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0037847 +name: vertebral joint disorder +def: "A disease that involves the intervertebral joint." [MONDO:patterns/location] +synonym: "disease of intervertebral joint" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of intervertebral joint" EXACT [] +synonym: "disorder of intervertebral joint" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disorder of joint of spine" EXACT [] +synonym: "intervertebral joint disease" EXACT [MONDO:design_pattern] +synonym: "intervertebral joint disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "spondyloarthropathy" RELATED [] +xref: SCTID:372109003 {source="MONDO:equivalentTo"} +is_a: MONDO:0000812 {source="MONDO:Redundant"} ! vertebral column disorder +is_a: MONDO:0006816 {source="MONDO:Redundant"} ! arthropathy +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001468 ! intervertebral joint +relationship: disease_has_location UBERON:0001468 ! intervertebral joint +property_value: exactMatch http://identifiers.org/snomedct/372109003 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0037858 +name: inherited fatty acid metabolism disorder +def: "A group of genetic disorders that result from the inability to produce or use an enzyme required to oxidize fatty acids, resulting in an inability to generate energy from fatty acid sources." [NCIT:C117115] +synonym: "disorder of fat oxidation" RELATED [] +synonym: "disorder of fatty acid metabolism" EXACT [] +synonym: "disorders of fatty-acid metabolism" RELATED [] +synonym: "fatty acid metabolism disorder" EXACT [NCIT:C117115] +synonym: "inherited fatty acid metabolism disorder" EXACT [] +xref: NCIT:C117115 {source="MONDO:equivalentTo"} +xref: SCTID:39929009 {source="MONDO:equivalentTo"} +is_a: MONDO:0000688 ! inherited organic acidemia +is_a: MONDO:0002525 {source="NCIT:C117115"} ! inherited lipid metabolism disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_disrupts GO:0006631 ! fatty acid metabolic process +relationship: disease_disrupts GO:0006631 ! fatty acid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/39929009 +property_value: exactMatch NCIT:C117115 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0037870 +name: valine metabolism disease +def: "A disease that has its basis in the disruption of valine metabolic process." [MONDO:design_pattern] +synonym: "disorder of valine metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of valine metabolism" EXACT [] +synonym: "valine metabolic process disease" EXACT [MONDO:design_pattern] +xref: SCTID:444756000 {source="MONDO:equivalentTo"} +xref: UMLS:C2919304 {source="MONDO:equivalentTo"} +is_a: MONDO:0037871 ! amino acid metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006573 ! valine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006573 ! valine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/444756000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2919304 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0037871 +name: amino acid metabolism disease +def: "A disease that has its basis in the disruption of cellular amino acid metabolic process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "amino acid disorder" RELATED [] +synonym: "amino acid metabolism disorder" EXACT [NCIT:C97090] +synonym: "amino acidopathy" RELATED [] +synonym: "cellular amino acid metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "disorder of amino acid metabolism" EXACT [] +synonym: "disorder of cellular amino acid metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +xref: NCIT:C97090 {source="MONDO:equivalentTo"} +xref: SCTID:44779003 {source="MONDO:equivalentTo"} +is_a: MONDO:0045022 ! disorder of organic acid metabolism +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006520 ! cellular amino acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006520 ! cellular amino acid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/44779003 +property_value: exactMatch NCIT:C97090 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0037937 +name: pyrimidine metabolism disease +def: "A disease that has its basis in the disruption of pyrimidine nucleobase metabolic process." [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of pyrimidine metabolism" EXACT [] +synonym: "disorder of pyrimidine nucleobase metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "pyrimidine nucleobase metabolic process disease" EXACT [MONDO:design_pattern] +xref: SCTID:85444005 {source="MONDO:equivalentTo"} +xref: UMLS:C0268127 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006206 ! pyrimidine nucleobase metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006206 ! pyrimidine nucleobase metabolic process +property_value: exactMatch http://identifiers.org/snomedct/85444005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268127 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0037938 +name: inborn disorder of aspartate family metabolism +def: "An acquired metabolic disease that is has its basis in the disruption of aspartate family amino acid metabolic process." [MONDO:patterns/inborn_metabolic] +synonym: "inborn aspartate family amino acid metabolic process disorder" EXACT [] +synonym: "inborn error of aspartate family amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "rare inborn error of aspartate family amino acid metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +is_a: MONDO:0004736 ! inherited amino acid metabolic disorder +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0009066 ! aspartate family amino acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009066 ! aspartate family amino acid metabolic process +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0037940 +name: inherited auditory system disease +def: "An instance of auditory system disease that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "auditory system hereditary disorder" EXACT [] +synonym: "hereditary auditory system disease" EXACT [MONDO:patterns/hereditary] +synonym: "inherited auditory system disease" EXACT [] +xref: SCTID:362991006 {source="MONDO:equivalentTo"} +xref: UMLS:C1285174 {source="MONDO:equivalentTo"} +is_a: MONDO:0002409 {source="MONDO:Redundant"} ! auditory system disorder +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0002409 ! auditory system disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/362991006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1285174 + +[Term] +id: MONDO:0040566 +name: inherited glutathione metabolism disease +def: "An acquired metabolic disease that is has its basis in the disruption of glutathione metabolic process." [MONDO:patterns/inborn_metabolic] +synonym: "glutathione metabolism disorder, inherited" EXACT [] +synonym: "inborn error of glutathione metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn error of glutathione metabolism" EXACT [] +synonym: "inborn glutathione metabolic process disorder" EXACT [] +synonym: "rare inborn error of glutathione metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: SCTID:72262000 {source="MONDO:equivalentTo"} +xref: UMLS:C0268518 {source="MONDO:equivalentTo"} +is_a: MONDO:0019241 ! inborn disorder of the gamma-glutamyl cycle +is_a: MONDO:0056803 ! sulfur metabolism disease +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0006749 ! glutathione metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006749 ! glutathione metabolic process +property_value: exactMatch http://identifiers.org/snomedct/72262000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268518 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0040673 +name: malignant peritoneal germ cell tumor +def: "A malignant germ cell tumor that affects the peritoneum." [NCIT:C136410] +synonym: "malignant peritoneal germ cell tumor" EXACT [NCIT:C136410] +xref: NCIT:C136410 {source="MONDO:equivalentTo"} +xref: UMLS:C4526657 {source="MONDO:equivalentTo"} +is_a: MONDO:0002087 {source="MONDO:Redundant", source="NCIT:C136410"} ! peritoneum cancer +is_a: MONDO:0003113 {source="NCIT:C136410"} ! extragonadal germ cell cancer +intersection_of: MONDO:0005040 ! germ cell tumor +intersection_of: disease_has_location UBERON:0002358 ! peritoneum +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4526657 +property_value: exactMatch NCIT:C136410 + +[Term] +id: MONDO:0040676 +name: great vessel cancer +def: "A malignant neoplasm arising from the great vessels." [NCIT:C4575] +synonym: "cancer of great vessel of heart" EXACT [MONDO:patterns/cancer] +synonym: "great vessel cancer" EXACT [NCIT:C4575] +synonym: "great vessel of heart cancer" EXACT [] +synonym: "malignant great vessel neoplasm" EXACT [NCIT:C4575] +synonym: "malignant great vessel of heart neoplasm" EXACT [MONDO:patterns/cancer] +synonym: "malignant great vessel tumor" EXACT [NCIT:C4575] +synonym: "malignant neoplasm of great vessel of heart" EXACT [MONDO:patterns/cancer] +xref: NCIT:C4575 {source="MONDO:equivalentTo"} +xref: UMLS:C3665405 {source="MONDO:equivalentTo", source="NCIT:C4575"} +is_a: MONDO:0002095 ! vascular cancer +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0013768 ! great vessel of heart +relationship: disease_has_location UBERON:0013768 ! great vessel of heart +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3665405 +property_value: exactMatch NCIT:C4575 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0040677 +name: invasive carcinoma +def: "A carcinoma that is not confined to the epithelium, and has spread to the surrounding stroma." [NCIT:C9480] +synonym: "invasive carcinoma" EXACT [NCIT:C9480] +xref: NCIT:C9480 {source="MONDO:equivalentTo"} +xref: UMLS:C1334274 {source="MONDO:equivalentTo", source="NCIT:C9480"} +is_a: MONDO:0004993 {source="MONDO:Redundant", source="NCIT:C9480"} ! carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: has_modifier PATO:0002129 ! neoplastic, invasive +relationship: has_modifier PATO:0002129 ! neoplastic, invasive +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334274 +property_value: exactMatch NCIT:C9480 + +[Term] +id: MONDO:0040678 +name: infiltrating urothelial carcinoma +def: "A invasive carcinoma that involves the urothelium." [MONDO:patterns/location] +synonym: "infiltrating transitional cell carcinoma of the urinary tract" EXACT [NCIT:C39853] +synonym: "infiltrating urothelial carcinoma" EXACT [NCIT:C39853] +xref: NCIT:C39853 {source="MONDO:equivalentTo"} +xref: UMLS:C1512751 {source="MONDO:equivalentTo", source="NCIT:C39853"} +is_a: MONDO:0006295 ! malignant urinary system neoplasm +is_a: MONDO:0024337 ! urothelial neoplasm +is_a: MONDO:0040677 {source="MONDO:Redundant", source="NCIT:C39853"} ! invasive carcinoma +intersection_of: MONDO:0040677 ! invasive carcinoma +intersection_of: disease_has_location UBERON:0000365 ! urothelium +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512751 +property_value: exactMatch NCIT:C39853 + +[Term] +id: MONDO:0040679 +name: urothelial carcinoma +def: "A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis). It is frequently papillary." [NCIT:C4030] +synonym: "transitional cell car. -uroth." EXACT [NCIT:C4030] +synonym: "transitional cell carcinoma of the urinary tract" EXACT [NCIT:C4030] +synonym: "transitional cell carcinoma of the urothelial tract" EXACT [NCIT:C4030] +synonym: "Uroepithelial carcinoma" EXACT [NCIT:C4030] +synonym: "urothelial carcinoma" EXACT [NCIT:C4030] +xref: EFO:0008528 {source="MONDO:equivalentTo"} +xref: NCIT:C4030 {source="MONDO:equivalentTo"} +xref: UMLS:C2145472 {source="NCIT:C4030", source="MONDO:equivalentTo"} +is_a: MONDO:0006295 {source="MONDO:Redundant", source="NCIT:C4030"} ! malignant urinary system neoplasm +is_a: MONDO:0006474 {source="EFO:0008528", source="MONDO:Redundant", source="NCIT:C4030"} ! transitional cell carcinoma +is_a: MONDO:0024337 {source="NCIT:C4030"} ! urothelial neoplasm +intersection_of: MONDO:0006474 ! transitional cell carcinoma +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2145472 +property_value: exactMatch NCIT:C4030 + +[Term] +id: MONDO:0041154 +name: disorder of neck of urinary bladder +synonym: "functional disorder of bladder neck and sphincter mechanism" EXACT [] +xref: SCTID:236644005 {source="MONDO:equivalentTo"} +is_a: MONDO:0006026 ! urinary bladder disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001258 ! neck of urinary bladder +relationship: disease_has_location UBERON:0001258 ! neck of urinary bladder +property_value: exactMatch http://identifiers.org/snomedct/236644005 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0041261 +name: disorder of acid-base balance +synonym: "disorder of acid-base balance" EXACT [] +synonym: "disturbance of acid-base balance" RELATED [] +xref: SCTID:26436007 {source="MONDO:equivalentTo"} +xref: UMLS:C0268029 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 ! metabolic disease +intersection_of: MONDO:0005066 ! metabolic disease +intersection_of: disease_disrupts GO:0006885 ! regulation of pH +relationship: disease_disrupts GO:0006885 ! regulation of pH +property_value: exactMatch http://identifiers.org/snomedct/26436007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268029 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0041284 +name: primary motor cortex epilepsy +def: "A epilepsy that involves the primary motor cortex." [MONDO:patterns/location] +comment: Editor note: TODO. Request Jacksonian seizures from HP? +synonym: "epilepsy of primary motor cortex" EXACT [MONDO:design_pattern] +synonym: "Jacksonian epilepsy" RELATED [] +synonym: "motor cortex epilepsy" RELATED [] +synonym: "primary motor cortex epilepsy" EXACT [MONDO:patterns/location] +xref: SCTID:267592003 {source="MONDO:equivalentTo"} +xref: UMLS:C0234978 {source="MONDO:equivalentTo"} +is_a: MONDO:0002612 {source="MONDO:Redundant", source="Wikipedia:Frontal_lobe_epilepsy"} ! frontal lobe epilepsy +is_a: MONDO:0044996 ! cerebral cortex disorder +intersection_of: MONDO:0005027 ! epilepsy +intersection_of: disease_has_location UBERON:0001384 ! primary motor cortex +relationship: disease_has_location UBERON:0001384 ! primary motor cortex +property_value: exactMatch http://identifiers.org/snomedct/267592003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0234978 + +[Term] +id: MONDO:0041366 +name: acute epiglottitis +def: "Acute form of epiglottitis." [MONDO:patterns/acute] +synonym: "acute epiglottitis" EXACT [] +synonym: "acute epiglottitis and supraglottitis" RELATED [] +synonym: "epiglottitis, acute" EXACT [MONDO:design_pattern, MONDO:patterns/acute] +xref: SCTID:29608009 {source="MONDO:equivalentTo"} +is_a: MONDO:0004777 ! acute laryngitis +is_a: MONDO:0005753 {source="MONDO:Redundant"} ! epiglottitis +intersection_of: MONDO:0005753 ! epiglottitis +intersection_of: has_modifier PATO:0000389 ! acute +property_value: exactMatch http://identifiers.org/snomedct/29608009 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0042451 +name: endomyometritis +def: "An inflammation of the endometrium and the myometrium." [ISBN-13:978-0-7817-5532-0, Wikipedia:Endometritis#cite_note-isbn0-7817-5532-8-2] +synonym: "endomyometritis" EXACT [] +xref: SCTID:88027004 {source="MONDO:equivalentTo"} +is_a: MONDO:0000497 ! pyometritis +is_a: MONDO:0000918 {source="MONDO:Redundant"} ! endometritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001295 ! endometrium +intersection_of: disease_has_inflammation_site UBERON:0001296 ! myometrium +property_value: exactMatch http://identifiers.org/snomedct/88027004 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0042485 +name: infective arthritis +def: "The inflammation of one or more joints caused by any infectious pathogen within the joint space. Symptoms include pain, stiffness, and decreased range of motion in the affected joint." [NCIT:C26700] +synonym: "infective arthritis" EXACT [NCIT:C26700] +synonym: "septic arthritis" RELATED [NCIT:C26700] +xref: GARD:0006781 {source="MONDO:equivalentTo"} +xref: NCIT:C26700 {source="MONDO:equivalentTo"} +is_a: MONDO:0005550 ! infectious disease +is_a: MONDO:0005578 {source="MONDO:Redundant", source="NCIT:C26700"} ! arthritic joint disease +intersection_of: MONDO:0005578 ! arthritic joint disease +intersection_of: disease_has_infectious_agent NCBITaxon:1 ! root +property_value: exactMatch NCIT:C26700 + +[Term] +id: MONDO:0042489 +name: disease susceptibility +def: "A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases." [MESH:D004198] +subset: predisposition +synonym: "diatheses" RELATED [MESH:D004198] +synonym: "diathesis" RELATED [MESH:D004198] +synonym: "disease susceptibilities" RELATED [MESH:D004198] +synonym: "susceptibilities, disease" RELATED [MESH:D004198] +synonym: "susceptibility, disease" RELATED [MESH:D004198] +xref: MESH:D004198 {source="MONDO:equivalentTo"} +is_a: BFO:0000016 ! disposition +property_value: exactMatch http://identifiers.org/mesh/D004198 + +[Term] +id: MONDO:0042493 +name: gastric non-hodgkin lymphoma +def: "An extranodal non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach. The vast majority of cases are diffuse large B-cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue." [NCIT:C27235] +subset: gard_rare +synonym: "gastric non-Hodgkin lymphoma" EXACT [NCIT:C27235] +synonym: "gastric non-Hodgkin's lymphoma" EXACT [NCIT:C27235] +synonym: "lymphoma, gastric non Hodgkins type" RELATED [GARD:0000089] +synonym: "non-Hodgkin lymphoma of stomach" EXACT [MONDO:design_pattern] +synonym: "non-Hodgkin's lymphoma of stomach" EXACT [NCIT:C27235] +synonym: "non-Hodgkin's lymphoma of the stomach" EXACT [NCIT:C27235] +synonym: "non-Hodgkins gastric lymphoma" RELATED [GARD:0000089] +synonym: "primary gastric non-Hodgkin's lymphoma" EXACT [NCIT:C27235] +synonym: "stomach lymphoma, non-Hodgkins type" RELATED [GARD:0000089] +synonym: "stomach non-Hodgkin lymphoma" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: GARD:0000089 {source="MONDO:equivalentTo"} +xref: NCIT:C27235 {source="MONDO:equivalentTo"} +xref: SCTID:448709005 {source="MONDO:equivalentTo"} +xref: UMLS:C1333784 {source="GARD:0000089", source="NCIT:C27235", source="MONDO:equivalentTo"} +is_a: MONDO:0001059 {source="MONDO:Redundant", source="NCIT:C27235"} ! gastric lymphoma +is_a: MONDO:0018908 ! non-Hodgkin lymphoma +intersection_of: MONDO:0018908 ! non-Hodgkin lymphoma +intersection_of: disease_has_location UBERON:0000945 ! stomach +property_value: exactMatch http://identifiers.org/snomedct/448709005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1333784 +property_value: exactMatch NCIT:C27235 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0042495 +name: arteriosclerotic retinopathy +def: "A arteriosclerosis disorder that involves the retina." [MONDO:patterns/location] +subset: gard_rare +synonym: "arteriosclerosis disorder of retina" EXACT [MONDO:design_pattern] +synonym: "arteriosclerosis, retina" RELATED [GARD:0000113] +synonym: "arteriosclerotic retinopathy" EXACT [] +synonym: "retina arteriosclerosis disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "retinal arteriosclerosis" RELATED [] +synonym: "retinopathy, arteriosclerotic" RELATED [GARD:0000113] +xref: GARD:0000113 {source="MONDO:equivalentTo"} +xref: ICD9:440.8 +xref: SCTID:95691008 {source="MONDO:equivalentTo"} +xref: UMLS:C0339478 {source="GARD:0000113", source="MONDO:equivalentTo"} +is_a: MONDO:0002277 {source="MONDO:Redundant"} ! arteriosclerosis disorder +is_a: MONDO:0002311 ! retinal vascular disorder +intersection_of: MONDO:0002277 ! arteriosclerosis disorder +intersection_of: disease_has_location UBERON:0000966 ! retina +relationship: disease_has_location UBERON:0001980 ! arteriole +property_value: exactMatch http://identifiers.org/snomedct/95691008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0339478 + +[Term] +id: MONDO:0042966 +name: inherited mitral valve disease +def: "An instance of mitral valve disease that is caused by an inherited modification of the individual's genome." [MONDO:patterns/hereditary] +synonym: "congenital anomaly of mitral valve" EXACT [] +synonym: "congenital malformation of mitral valve" RELATED [] +synonym: "congenital mitral valve abnormality" RELATED [] +synonym: "hereditary mitral valve disease" EXACT [MONDO:patterns/hereditary] +xref: SCTID:75372006 {source="MONDO:equivalentTo"} +is_a: MONDO:0003767 {source="MONDO:Redundant"} ! mitral valve disorder +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0003767 ! mitral valve disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch http://identifiers.org/snomedct/75372006 + +[Term] +id: MONDO:0042967 +name: rheumatic disease of mitral valve +def: "A rheumatologic disorder that involves the mitral valve." [MONDO:patterns/location] +synonym: "mitral valve rheumatologic disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "rheumatic disease of mitral valve" EXACT [] +synonym: "rheumatic mitral valve changes" RELATED [] +synonym: "rheumatic mitral valve disease" RELATED [] +synonym: "rheumatologic disorder of mitral valve" EXACT [MONDO:design_pattern] +xref: SCTID:83898004 {source="MONDO:equivalentTo"} +xref: UMLS:C0264765 {source="MONDO:equivalentTo"} +is_a: MONDO:0003767 {source="MONDO:Redundant"} ! mitral valve disorder +is_a: MONDO:0005554 ! rheumatic disorder +intersection_of: MONDO:0005554 ! rheumatic disorder +intersection_of: disease_has_location UBERON:0002135 ! mitral valve +property_value: exactMatch http://identifiers.org/snomedct/83898004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0264765 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0042970 +name: disorder of glutamate decarboxylase +def: "A disease that has its basis in the disruption of glutamate decarboxylase activity." [MONDO:design_pattern] +subset: gard_rare +synonym: "deficiency of glutamate decarboxylase" EXACT [GTR:AN0168165] +synonym: "disorder of glutamate decarboxylase activity" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "glutamate decarboxylase activity disease" EXACT [MONDO:design_pattern] +synonym: "glutamate decarboxylase deficiency" RELATED [GTR:AN0264281] +xref: GARD:0002505 {source="MONDO:equivalentTo"} +xref: GTR:AN0168165 {source="UMLS:C1291560"} +xref: GTR:AN0264281 {source="UMLS:C1291560"} +xref: ICD9:277.6 +xref: MEDGEN:452941 {source="UMLS:C1291560"} +xref: SCTID:124596009 {source="MONDO:equivalentTo", source="UMLS:C1291560"} +xref: UMLS:C1291560 {source="MONDO:equivalentTo", source="GARD:0002505"} +is_a: MONDO:0005066 {source="GARD:0002505", source="https://orcid.org/0000-0001-5208-3432"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0004351 ! glutamate decarboxylase activity +relationship: disease_has_basis_in_disruption_of GO:0004351 ! glutamate decarboxylase activity +property_value: closeMatch http://identifiers.org/medgen/452941 +property_value: exactMatch http://identifiers.org/snomedct/124596009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1291560 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0042976 +name: vitamin B deficiency +def: "A condition due to deficiency in any member of the vitamin B complex. These B vitamins are water-soluble and must be obtained from the diet because they are easily lost in the urine. Unlike the lipid-soluble vitamins, they cannot be stored in the body fat." [MESH:D014804] +synonym: "deficiencies, vitamin B" RELATED [MESH:D014804] +synonym: "deficiency, vitamin B" RELATED [MESH:D014804] +synonym: "vitamin B deficiencies" RELATED [MESH:D014804] +xref: MESH:D014804 {source="MONDO:equivalentTo"} +xref: NCIT:C35129 {source="MONDO:equivalentTo"} +xref: SCTID:47903000 {source="MONDO:equivalentTo"} +xref: UMLS:C0042850 {source="MONDO:equivalentTo"} +is_a: MONDO:0024298 {source="MESH:D014804", source="NCIT:C35129"} ! vitamin deficiency disorder +property_value: exactMatch http://identifiers.org/mesh/D014804 +property_value: exactMatch http://identifiers.org/snomedct/47903000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0042850 +property_value: exactMatch NCIT:C35129 + +[Term] +id: MONDO:0043218 +name: neurovascular disorder +def: "A disorder of the nervous system related to a vascular etiology." [NCIT:C117007] +synonym: "disease of nervous system vasculature" EXACT [] +synonym: "nervous system disorder of vasculature" EXACT [MONDO:design_pattern] +synonym: "neurovascular disorder" EXACT [NCIT:C117007] +synonym: "vasculature nervous system disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: NCIT:C117007 {source="MONDO:equivalentTo"} +xref: UMLS:C3898144 {source="MONDO:equivalentTo", source="NCIT:C117007"} +is_a: MONDO:0005071 {source="MONDO:Redundant", source="NCIT:C117007"} ! nervous system disorder +is_a: MONDO:0005385 ! vascular disorder +intersection_of: MONDO:0005071 ! nervous system disorder +intersection_of: disease_has_location UBERON:0002049 ! vasculature +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3898144 +property_value: exactMatch NCIT:C117007 + +[Term] +id: MONDO:0043424 +name: digestive system infectious disorder +def: "A viral, bacterial, fungal, or parasitic infectious process that affects the digestive system." [NCIT:C35503] +synonym: "digestive system infection" EXACT [NCIT:C35503] +synonym: "gastrointestinal infection" EXACT [NCIT:C35503] +synonym: "gastrointestinal system infection" EXACT [NCIT:C35503] +synonym: "infection of gastrointestinal tract" RELATED [] +xref: NCIT:C35503 {source="MONDO:equivalentTo"} +xref: SCTID:715852004 {source="MONDO:equivalentTo"} +is_a: MONDO:0004335 ! digestive system disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0005409 ! alimentary part of gastrointestinal system +property_value: exactMatch http://identifiers.org/snomedct/715852004 +property_value: exactMatch NCIT:C35503 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0043494 +name: arteritis +def: "An inflammatory process affecting an artery." [NCIT:C34399] +synonym: "arterial Inflammation" RELATED [MESH:D001167] +synonym: "Arteritides" RELATED [MESH:D001167] +synonym: "arteritis" EXACT [NCIT:C34399] +synonym: "artery inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "inflammation of artery" EXACT [] +synonym: "Inflammation, arterial" RELATED [MESH:D001167] +xref: EFO:0009011 {source="MONDO:equivalentTo"} +xref: HP:0012089 {source="MONDO:otherHierarchy"} +xref: MESH:D001167 {source="MONDO:equivalentTo"} +xref: NCIT:C34399 {source="MONDO:equivalentTo"} +xref: SCTID:52089001 {source="MONDO:equivalentTo"} +is_a: MONDO:0000473 {source="MONDO:Redundant", source="NCIT:C34399"} ! arterial disorder +is_a: MONDO:0018882 {source="EFO:0009011", source="MESH:D001167", source="MONDO:Redundant", source="NCIT:C34399"} ! vasculitis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0001637 ! artery +relationship: disease_has_inflammation_site UBERON:0001637 ! artery +property_value: exactMatch http://identifiers.org/mesh/D001167 +property_value: exactMatch http://identifiers.org/snomedct/52089001 +property_value: exactMatch NCIT:C34399 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0043541 +name: viral conjunctivitis +def: "Conjunctivitis resulting from viral infection." [NCIT:C34509] +synonym: "Conjunctivitides, viral" RELATED [MESH:D003236] +synonym: "viral Conjunctivitides" RELATED [MESH:D003236] +synonym: "viral conjunctivitis" EXACT [MESH:D003236, NCIT:C34509] +synonym: "Viruses caused conjunctivitis (disease)" EXACT [MONDO:patterns/specific_infectious_disease_by_agent] +synonym: "Viruses conjunctivitis (disease)" EXACT [] +xref: MESH:D003236 {source="MONDO:equivalentTo"} +xref: NCIT:C34509 {source="MONDO:equivalentTo"} +xref: SCTID:45261009 {source="MONDO:equivalentTo"} +xref: UMLS:C0009774 {source="NCIT:C34509", source="MONDO:equivalentTo"} +is_a: MONDO:0003799 {source="MESH:D003236", source="MONDO:Redundant", source="NCIT:C34509/inferred"} ! conjunctivitis +is_a: MONDO:0043885 ! eye infectious disorder +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +intersection_of: disease_has_inflammation_site UBERON:0001811 ! conjunctiva +relationship: disease_has_infectious_agent NCBITaxon:10239 ! Viruses +property_value: exactMatch http://identifiers.org/mesh/D003236 +property_value: exactMatch http://identifiers.org/snomedct/45261009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0009774 +property_value: exactMatch NCIT:C34509 + +[Term] +id: MONDO:0043576 +name: endarteritis +def: "Inflammation of the arterial intima." [NCIT:C34581] +synonym: "Endarteritides" RELATED [MESH:D004692] +synonym: "endarteritis" EXACT [NCIT:C34581] +synonym: "inflammation of tunica intima of artery" EXACT [] +synonym: "tunica intima of artery inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: EFO:0009084 {source="MONDO:equivalentTo"} +xref: MESH:D004692 {source="MONDO:equivalentTo"} +xref: NCIT:C34581 {source="MONDO:equivalentTo"} +xref: SCTID:33806008 {source="MONDO:equivalentTo"} +xref: UMLS:C0014100 {source="NCIT:C34581", source="MONDO:equivalentTo"} +is_a: MONDO:0043494 ! arteritis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0005740 ! tunica intima of artery +relationship: disease_has_inflammation_site UBERON:0005740 ! tunica intima of artery +property_value: exactMatch http://identifiers.org/mesh/D004692 +property_value: exactMatch http://identifiers.org/snomedct/33806008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014100 +property_value: exactMatch NCIT:C34581 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0043579 +name: enteritis +def: "Inflammation of the small intestine." [NCIT:C26765] +synonym: "Enteritides" RELATED [MESH:D004751] +synonym: "enteritis" EXACT [NCIT:C26765] +synonym: "enteritis of small intestine" EXACT [] +synonym: "enteritis, inflammatory disorder of small intestine" RELATED [] +synonym: "inflammation of small intestine" EXACT [] +synonym: "small intestine inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: MESH:D004751 {source="MONDO:equivalentTo"} +xref: NCIT:C26765 {source="MONDO:equivalentTo"} +xref: SCTID:64613007 {source="MONDO:equivalentTo"} +xref: UMLS:C0014335 {source="MONDO:equivalentTo", source="NCIT:C26765"} +is_a: MONDO:0002269 {source="MESH:D004751", source="MONDO:Redundant"} ! gastroenteritis +is_a: MONDO:0024635 {source="MONDO:Redundant"} ! small intestine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0002108 ! small intestine +relationship: disease_has_inflammation_site UBERON:0002108 ! small intestine +property_value: exactMatch http://identifiers.org/mesh/D004751 +property_value: exactMatch http://identifiers.org/snomedct/64613007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0014335 +property_value: exactMatch NCIT:C26765 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0043693 +name: alcoholic liver diseases +def: "A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis." [NCIT:C34783] +synonym: "alcoholic liver damage" NARROW [] +synonym: "alcoholic liver disease" EXACT [MESH:D008108, NCIT:C34783] +synonym: "alcoholic liver diseases" EXACT [MESH:D008108] +synonym: "liver disease, alcoholic" RELATED [MESH:D008108] +xref: EFO:0008573 {source="MONDO:equivalentTo"} +xref: MESH:D008108 {source="MONDO:equivalentTo"} +xref: NCIT:C34783 {source="MONDO:equivalentTo"} +xref: SCTID:41309000 {source="MONDO:equivalentTo"} +is_a: MONDO:0005154 {source="EFO:0008573", source="MESH:D008108", source="MONDO:Redundant", source="NCIT:C34783/inferred"} ! liver disorder +is_a: MONDO:0021699 {source="MESH:D008108"} ! alcohol-induced disorders +intersection_of: MONDO:0005154 ! liver disorder +intersection_of: realized_in_response_to ECTO:0001082 ! exposure to alcohol consumption +property_value: exactMatch http://identifiers.org/mesh/D008108 +property_value: exactMatch http://identifiers.org/snomedct/41309000 +property_value: exactMatch NCIT:C34783 + +[Term] +id: MONDO:0043786 +name: serositis +def: "Inflammation of a serous membrane." [NCIT:C70428] +synonym: "inflammation of serous membrane" EXACT [] +synonym: "Serositides" RELATED [MESH:D012700] +synonym: "serositis" EXACT [NCIT:C70428] +synonym: "serous membrane inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +xref: MESH:D012700 {source="MONDO:equivalentTo"} +xref: NCIT:C70428 {source="MONDO:equivalentTo"} +xref: SCTID:370469003 {source="MONDO:equivalentTo"} +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0000042 ! serous membrane +relationship: disease_has_inflammation_site UBERON:0000042 ! serous membrane +property_value: exactMatch http://identifiers.org/mesh/D012700 +property_value: exactMatch http://identifiers.org/snomedct/370469003 +property_value: exactMatch NCIT:C70428 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0043862 +name: voice disorders +def: "A pathologic process in the larynx that affects the production of speech. Causes include vocal cord paresis, vocal cord nodule, vocal cord polyp, and laryngitis." [NCIT:C3441] +synonym: "neurologic dysphonia" RELATED [] +synonym: "neurologic voice disorder" EXACT [] +synonym: "voice disorder" EXACT [NCIT:C3441] +xref: MESH:D014832 {source="MONDO:equivalentTo"} +xref: NCIT:C3441 {source="MONDO:equivalentTo"} +xref: SCTID:71941009 {source="MONDO:equivalentTo"} +is_a: MONDO:0004382 {source="MESH:D014832", source="NCIT:C3441/inferred"} ! laryngeal disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0071625 ! vocalization behavior +relationship: disease_disrupts GO:0071625 ! vocalization behavior +property_value: exactMatch http://identifiers.org/mesh/D014832 +property_value: exactMatch http://identifiers.org/snomedct/71941009 +property_value: exactMatch NCIT:C3441 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0043885 +name: eye infectious disorder +def: "An infectious process affecting any part of the eye. Causes include viruses and bacteria. Symptoms include itching and discomfort in the eye, watery eyes, eye pain and discharge, and blurring vision. Representative examples include pink eye, blepharitis, and trachoma." [NCIT:C45372] +synonym: "eye infection" EXACT [MESH:D015817, NCIT:C45372] +synonym: "infection, eye" RELATED [MESH:D015817] +synonym: "infection, ocular" RELATED [MESH:D015817] +synonym: "infections, eye" RELATED [MESH:D015817] +synonym: "infections, ocular" RELATED [MESH:D015817] +synonym: "ocular infection" RELATED [MESH:D015817] +synonym: "ocular infections" RELATED [MESH:D015817] +xref: MESH:D015817 {source="MONDO:equivalentTo"} +xref: NCIT:C45372 {source="MONDO:equivalentTo"} +xref: SCTID:128351009 {source="MONDO:equivalentTo"} +xref: UMLS:C0015403 {source="NCIT:C45372", source="MONDO:equivalentTo"} +is_a: MONDO:0005328 {source="MESH:D015817", source="NCIT:C45372/inferred"} ! eye disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0000970 ! eye +property_value: exactMatch http://identifiers.org/mesh/D015817 +property_value: exactMatch http://identifiers.org/snomedct/128351009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0015403 +property_value: exactMatch NCIT:C45372 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0043905 +name: pneumonitis +def: "An inflammatory process affecting the lung parenchyma. It is a milder form of lung inflammation compared to pneumonia." [NCIT:C113159] +comment: Pneumonitis typically refers to non-infectious inflammation, whereas pneumonia refers to infectious +synonym: "inflammation of lung parenchyma" EXACT [] +synonym: "lung parenchyma inflammation" EXACT [MONDO:patterns/inflammatory_disease_by_site] +synonym: "pneumonitis" EXACT [NCIT:C113159] +xref: NCIT:C113159 {source="MONDO:equivalentTo"} +xref: SCTID:205237003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005275 {source="MONDO:Redundant", source="NCIT:C113159/inferred"} ! lung disorder +is_a: MONDO:0021166 ! inflammatory disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_inflammation_site UBERON:0008946 ! lung parenchyma +relationship: disease_has_inflammation_site UBERON:0008946 ! lung parenchyma +property_value: exactMatch http://identifiers.org/snomedct/205237003 +property_value: exactMatch NCIT:C113159 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inflammatory_disease_by_site.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml + +[Term] +id: MONDO:0044013 +name: puerperal disorder +def: "Disorders or diseases associated with puerperium, the six-to-eight-week period immediately after parturition in humans." [MESH:D011644] +synonym: "disorder of puerperium" EXACT [] +synonym: "disorder, puerperal" RELATED [MESH:D011644] +synonym: "disorders, puerperal" RELATED [MESH:D011644] +synonym: "postpartum disorder" RELATED [] +synonym: "puerperal disorder" EXACT [MESH:D011644] +xref: MESH:D011644 {source="MONDO:equivalentTo"} +xref: SCTID:362973001 {source="MONDO:equivalentTo"} +xref: UMLS:C0034040 {source="MONDO:equivalentTo"} +is_a: MONDO:0700003 {source="https://github.com/monarch-initiative/mondo/issues/3161", source="https://orcid.org/0000-0002-4142-7153"} ! obstetric disorder +property_value: exactMatch http://identifiers.org/mesh/D011644 +property_value: exactMatch http://identifiers.org/snomedct/362973001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0034040 +property_value: excluded_subClassOf MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/652"} +property_value: excluded_subClassOf MONDO:0024575 {source="MESH:D011644"} + +[Term] +id: MONDO:0044014 +name: postpartum thyroiditis +def: "A transient autoimmune Inflammatory disorder of thyroid gland that occurs postpartum due to any partum problem. It is characterized by the presence of high titers of autoantibodies against thyroid peroxidase and thyroglobulin. Clinical signs include the triphasic thyroid hormone pattern: beginning with thyrotoxicosis, followed with hypothyroidism, then return to euthyroid state by 1 year postpartum" [MESH:D050032, NCIT:C114389] +synonym: "post partum thyroiditis" RELATED [MESH:D050032] +synonym: "post-partum thyroiditides" RELATED [MESH:D050032] +synonym: "post-partum thyroiditis" RELATED [MESH:D050032] +synonym: "postpartum thyroiditides" RELATED [MESH:D050032] +synonym: "postpartum thyroiditis" EXACT [NCIT:C114389] +synonym: "thyroiditides, post-partum" RELATED [MESH:D050032] +synonym: "thyroiditides, postpartum" RELATED [MESH:D050032] +synonym: "thyroiditis, post-partum" RELATED [MESH:D050032] +synonym: "thyroiditis, postpartum" RELATED [MESH:D050032] +xref: MESH:D050032 {source="MONDO:equivalentTo"} +xref: NCIT:C114389 {source="MONDO:equivalentTo"} +xref: SCTID:52772002 {source="MONDO:equivalentTo"} +xref: UMLS:C0271815 {source="MONDO:equivalentTo", source="NCIT:C114389"} +is_a: MONDO:0005623 {source="MESH:D050032"} ! autoimmune thyroid disease +is_a: MONDO:0044013 ! puerperal disorder +intersection_of: MONDO:0004126 ! thyroiditis +intersection_of: MONDO:0044013 ! puerperal disorder +property_value: exactMatch http://identifiers.org/mesh/D050032 +property_value: exactMatch http://identifiers.org/snomedct/52772002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271815 +property_value: exactMatch NCIT:C114389 + +[Term] +id: MONDO:0044137 +name: vitreous body disorder +def: "Any disease affecting the vitreous body of the eye." [NCIT:C45256] +synonym: "disease of vitreous body" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of vitreous body" EXACT [] +synonym: "disorder of vitreous body" EXACT [MONDO:patterns/location_top] +synonym: "vitreous body disease" EXACT [MONDO:design_pattern] +synonym: "vitreous body disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "vitreous body disorder" EXACT [NCIT:C45256] +xref: EFO:0008624 {source="MONDO:equivalentTo"} +xref: ICD9:379.29 +xref: NCIT:C45256 {source="MONDO:equivalentTo"} +xref: SCTID:76682005 {source="MONDO:equivalentTo"} +xref: UMLS:C0155365 {source="MONDO:equivalentTo", source="NCIT:C45256"} +is_a: MONDO:0005328 {source="EFO:0008624", source="MONDO:Redundant", source="NCIT:C45256"} ! eye disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001798 ! vitreous body +relationship: disease_has_location UBERON:0001798 ! vitreous body +property_value: exactMatch http://identifiers.org/snomedct/76682005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0155365 +property_value: exactMatch NCIT:C45256 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044334 +name: connective and soft tissue neoplasm +def: "A benign, intermediate, or malignant neoplasm that affects the connective and soft tissue." [NCIT:C3810] +comment: Editor note: we follow NCIT in making this a grouping of all soft tissue and connective tissue neoplasms, including bone +synonym: "connective and soft tissue neoplasm" EXACT [NCIT:C3810] +synonym: "connective and soft tissue tumor" EXACT [NCIT:C3810] +synonym: "musculoskeletal and soft tissue neoplasm" EXACT [NCIT:C3810] +synonym: "musculoskeletal and soft tissue tumor" EXACT [NCIT:C3810] +synonym: "neoplasm of skeletal and soft tissue" EXACT [NCIT:C3810] +synonym: "neoplasm of soft tissue and bone" EXACT [NCIT:C3810] +synonym: "neoplasm of soft tissue and skeleton" EXACT [NCIT:C3810] +synonym: "skeletal and soft tissue neoplasm" EXACT [NCIT:C3810] +synonym: "skeletal and soft tissue tumor" EXACT [NCIT:C3810] +synonym: "soft tissue and bone neoplasm" EXACT [NCIT:C3810] +synonym: "soft tissue and bone tumor" EXACT [NCIT:C3810] +synonym: "tumor of skeletal and soft tissue" EXACT [NCIT:C3810] +synonym: "tumor of soft tissue and bone" EXACT [NCIT:C3810] +synonym: "tumor of soft tissue and skeleton" EXACT [NCIT:C3810] +xref: NCIT:C3810 {source="MONDO:equivalentTo"} +is_a: MONDO:0005070 {source="NCIT:C3810/inferred"} ! neoplasm +property_value: exactMatch NCIT:C3810 + +[Term] +id: MONDO:0044338 +name: autoimmune primary ovarian failure +def: "An autoimmune form of primary ovarian failure." [MONDO:patterns/autoimmune] +synonym: "primary ovarian failure arising through autoimmunity" EXACT [] +xref: ICD9:256.39 +xref: ICD9:279.49 +xref: SCTID:237790001 {source="MONDO:equivalentTo"} +xref: UMLS:C0342508 {source="MONDO:equivalentTo"} +is_a: MONDO:0000569 {source="MONDO:Redundant"} ! autoimmune disorder of endocrine system +is_a: MONDO:0005387 ! primary ovarian failure +intersection_of: MONDO:0005387 ! primary ovarian failure +intersection_of: disease_arises_from_feature HP:0002960 ! Autoimmunity +property_value: exactMatch http://identifiers.org/snomedct/237790001 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342508 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/autoimmune.yaml + +[Term] +id: MONDO:0044347 +name: erythrocyte disorder +def: "A disease or disorder that involves the erythrocyte." [MONDO:patterns/location] +synonym: "disease of erythrocyte" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of erythrocyte" EXACT [] +synonym: "disorder of erythrocyte" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "erythrocyte disease" EXACT [MONDO:design_pattern] +synonym: "erythrocyte disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "red blood cell disease" EXACT [] +synonym: "red blood cell disorder" EXACT [] +xref: ICD9:289.9 +xref: SCTID:38292009 {source="MONDO:equivalentTo"} +xref: UMLS:C0221016 {source="MONDO:equivalentTo"} +is_a: MONDO:0005570 ! hematologic disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location CL:0000232 ! erythrocyte +relationship: disease_has_location CL:0000232 ! erythrocyte +property_value: exactMatch http://identifiers.org/snomedct/38292009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0221016 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044348 +name: hemoglobinopathy +synonym: "globin abnormality" RELATED [] +synonym: "hemoglobin disease" RELATED [] +synonym: "hemoglobin disorder" RELATED [] +synonym: "hemoglobinopathy" EXACT [] +xref: ICD9:282.7 +xref: SCTID:80141007 {source="MONDO:equivalentTo"} +is_a: MONDO:0044347 ! erythrocyte disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of CHEBI:35143 ! hemoglobin +relationship: disease_has_basis_in_dysfunction_of CHEBI:35143 ! hemoglobin +relationship: disease_has_feature MONDO:0002280 ! anemia +property_value: exactMatch http://identifiers.org/snomedct/80141007 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0044349 +name: acquired hemoglobinopathy +def: "An instance of hemoglobinopathy that is acquired during the lifetime of the individual." [MONDO:patterns/acquired] +synonym: "acquired hemoglobinopathy" EXACT [MONDO:patterns/acquired] +xref: SCTID:127039000 {source="MONDO:equivalentTo"} +xref: UMLS:C1263995 {source="MONDO:equivalentTo"} +is_a: MONDO:0044348 {source="MONDO:Redundant"} ! hemoglobinopathy +intersection_of: MONDO:0044348 ! hemoglobinopathy +intersection_of: has_modifier MONDO:0021141 ! acquired +relationship: has_modifier MONDO:0021141 ! acquired +property_value: exactMatch http://identifiers.org/snomedct/127039000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263995 + +[Term] +id: MONDO:0044626 +name: female infertility due to oocyte meiotic arrest +subset: ordo_disease +xref: Orphanet:488191 {source="MONDO:equivalentTo"} +is_a: MONDO:0021124 {source="MONDO:Redundant", source="Orphanet:488191"} ! female infertility +intersection_of: MONDO:0021124 ! female infertility +intersection_of: disease_has_basis_in_disruption_of GO:0051321 ! meiotic cell cycle +relationship: disease_has_basis_in_disruption_of GO:0051321 ! meiotic cell cycle +property_value: exactMatch Orphanet:488191 + +[Term] +id: MONDO:0044638 +name: hypopharynx squamous cell carcinoma +def: "A squamous cell carcinoma that involves the hypopharynx." [MONDO:patterns/location] +subset: ordo_disease +synonym: "epidermoid carcinoma of hypopharynx" EXACT [NCIT:C4043] +synonym: "epidermoid carcinoma of the hypopharynx" EXACT [NCIT:C4043] +synonym: "hypopharyngeal epidermoid carcinoma" EXACT [NCIT:C4043] +synonym: "hypopharyngeal squamous cell carcinoma" EXACT [NCIT:C4043] +synonym: "hypopharyngeal throat squamous cell cancer" EXACT [NCIT:C4043] +synonym: "squamous cell carcinoma of hypopharynx" EXACT [NCIT:C4043] +synonym: "squamous cell carcinoma of the hypopharynx" RELATED [Orphanet:494547] +xref: EFO:1001960 {source="MONDO:equivalentTo"} +xref: NCIT:C4043 {source="MONDO:equivalentTo"} +xref: ONCOTREE:HPHSC {source="MONDO:equivalentTo"} +xref: Orphanet:494547 {source="MONDO:equivalentTo"} +is_a: MONDO:0000536 ! pharyngeal squamous cell carcinoma +is_a: MONDO:0005216 ! hypopharyngeal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001051 ! hypopharynx +property_value: exactMatch NCIT:C4043 +property_value: exactMatch Orphanet:494547 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0044704 +name: oropharynx squamous cell carcinoma +def: "A squamous cell carcinoma that involves the oropharynx." [MONDO:patterns/location] +subset: ordo_disease +synonym: "epidermoid carcinoma of oropharynx" EXACT [NCIT:C8181] +synonym: "epidermoid carcinoma of the oropharynx" EXACT [NCIT:C8181] +synonym: "oropharyngeal epidermoid carcinoma" EXACT [NCIT:C8181] +synonym: "oropharyngeal squamous cell carcinoma" EXACT [NCIT:C8181] +synonym: "oropharyngeal throat squamous cell cancer" EXACT [NCIT:C8181] +synonym: "squamous cell carcinoma of oropharynx" EXACT [NCIT:C8181] +synonym: "squamous cell carcinoma of the oropharynx" RELATED [Orphanet:500478] +xref: NCIT:C8181 {source="MONDO:equivalentTo"} +xref: ONCOTREE:OPHSC {source="MONDO:equivalentTo"} +xref: Orphanet:500478 {source="MONDO:equivalentTo"} +is_a: MONDO:0000536 ! pharyngeal squamous cell carcinoma +is_a: MONDO:0044926 ! oropharyngeal carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001729 ! oropharynx +property_value: exactMatch NCIT:C8181 +property_value: exactMatch Orphanet:500478 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0044705 +name: paranasal sinus squamous cell carcinoma +def: "A squamous cell carcinoma that arises from the mucosal epithelial surface of the ethmoid, frontal, maxillary, or sphenoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis." [NCIT:C8193] +subset: ordo_disease +synonym: "epidermoid carcinoma of paranasal sinus" EXACT [NCIT:C8193] +synonym: "epidermoid carcinoma of the paranasal sinus" EXACT [NCIT:C8193] +synonym: "paranasal sinus epidermoid carcinoma" EXACT [NCIT:C8193] +synonym: "paranasal sinus squamous cell carcinoma" EXACT [NCIT:C8193] +synonym: "squamous cell carcinoma of paranasal sinus" EXACT [NCIT:C8193] +synonym: "squamous cell carcinoma of the nasal cavity and paranasal sinuses" RELATED [Orphanet:500464] +synonym: "squamous cell carcinoma of the nasal cavity and sinuses" EXACT [Orphanet:500464] +synonym: "squamous cell carcinoma of the paranasal sinus" EXACT [NCIT:C8193] +xref: NCIT:C8193 {source="MONDO:equivalentTo"} +xref: Orphanet:500464 {source="MONDO:equivalentTo"} +xref: UMLS:C0280334 {source="MONDO:equivalentTo"} +is_a: MONDO:0000380 {source="MONDO:Redundant", source="NCIT:C8193"} ! paranasal sinus carcinoma +is_a: MONDO:0000514 ! bone squamous cell carcinoma +is_a: MONDO:0010150 ! head and neck squamous cell carcinoma +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001825 ! paranasal sinus +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280334 +property_value: exactMatch NCIT:C8193 +property_value: exactMatch Orphanet:500464 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0044710 +name: lip and oral cavity squamous cell carcinoma +def: "A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes." [NCIT:C42690] +subset: disease_grouping +subset: ordo_group_of_disorders +synonym: "lip and oral cavity squamous cell cancer" EXACT [NCIT:C42690] +synonym: "lip and oral cavity squamous cell carcinoma" EXACT [NCIT:C42690] +synonym: "lip/oral cavity squam. cell car." EXACT [NCIT:C42690] +synonym: "squamous cell carcinoma of oral cavity and lip" RELATED [Orphanet:502369] +xref: NCIT:C42690 {source="MONDO:equivalentTo"} +xref: Orphanet:502369 {source="MONDO:equivalentTo"} +xref: UMLS:C0280297 {source="MONDO:equivalentTo"} +is_a: MONDO:0010150 {source="MONDO:Redundant", source="NCIT:C42690"} ! head and neck squamous cell carcinoma +is_a: MONDO:0023644 {source="MONDO:Redundant", source="NCIT:C42690"} ! lip and oral cavity carcinoma +is_a: MONDO:0024623 {source="MONDO:0020035-obsoleted"} ! otorhinolaryngologic disease +intersection_of: MONDO:0010150 {source="NCIT:C42690"} ! head and neck squamous cell carcinoma +intersection_of: MONDO:0023644 {source="NCIT:C42690"} ! lip and oral cavity carcinoma +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280297 +property_value: exactMatch NCIT:C42690 +property_value: exactMatch Orphanet:502369 + +[Term] +id: MONDO:0044740 +name: salivary gland squamous cell carcinoma +def: "A squamous cell carcinoma arising from the salivary glands. The majority of patients are in their sixth through eight decades. It usually presents as a rapidly enlarging mass, which may be painful. It usually has an aggressive clinical course." [NCIT:C7991] +subset: ordo_histopathological_subtype +synonym: "epidermoid carcinoma of salivary gland" EXACT [NCIT:C7991] +synonym: "epidermoid carcinoma of the salivary gland" EXACT [NCIT:C7991] +synonym: "saliva-secreting gland squamous cell carcinoma" EXACT [] +synonym: "salivary gland epidermoid carcinoma" EXACT [NCIT:C7991] +synonym: "salivary gland SCC" EXACT [NCIT:C7991] +synonym: "salivary gland squamous cell cancer" EXACT [NCIT:C7991] +synonym: "salivary gland squamous cell carcinoma" EXACT [NCIT:C7991] +synonym: "SCC of salivary gland" EXACT [NCIT:C7991] +synonym: "SCC of the salivary gland" EXACT [NCIT:C7991] +synonym: "squamous cell carcinoma of salivary gland" EXACT [NCIT:C7991] +synonym: "squamous cell carcinoma of salivary glands" RELATED [Orphanet:500481] +synonym: "squamous cell carcinoma of the salivary gland" EXACT [NCIT:C7991] +xref: EFO:1001967 {source="MONDO:equivalentTo"} +xref: NCIT:C7991 {source="MONDO:equivalentTo"} +xref: Orphanet:500481 {source="MONDO:equivalentTo"} +xref: UMLS:C0279697 {source="MONDO:equivalentTo"} +is_a: MONDO:0000521 {source="MONDO:Redundant", source="NCIT:C7991"} ! salivary gland carcinoma +is_a: MONDO:0004958 ! oral cavity squamous cell carcinoma +is_a: MONDO:0017167 {source="Orphanet:500481"} ! malignant epithelial tumor of salivary glands +intersection_of: MONDO:0005096 ! squamous cell carcinoma +intersection_of: disease_has_location UBERON:0001044 ! saliva-secreting gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0279697 +property_value: exactMatch NCIT:C7991 +property_value: exactMatch Orphanet:500481 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/squamous_cell_carcinoma.yaml + +[Term] +id: MONDO:0044743 +name: major salivary gland cancer +def: "A primary or metastatic malignant neoplasm affecting the major salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma." [NCIT:C4762] +synonym: "cancer of major salivary gland" EXACT [MONDO:patterns/cancer] +synonym: "malignant major salivary gland neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C4762] +synonym: "malignant major salivary gland tumor" EXACT [NCIT:C4762] +synonym: "malignant neoplasm of major salivary gland" EXACT [MONDO:patterns/cancer, NCIT:C4762] +synonym: "malignant neoplasm of major salivary glands" RELATED [] +synonym: "malignant neoplasm of the major salivary gland" EXACT [NCIT:C4762] +synonym: "malignant tumor of major salivary gland" EXACT [NCIT:C4762] +synonym: "malignant tumor of the major salivary gland" EXACT [NCIT:C4762] +xref: NCIT:C4762 {source="MONDO:equivalentTo"} +xref: SCTID:363378008 {source="MONDO:equivalentTo"} +xref: UMLS:C0496763 {source="MONDO:equivalentTo", source="NCIT:C4762"} +is_a: MONDO:0004669 {source="MONDO:Redundant", source="NCIT:C4762"} ! salivary gland cancer +is_a: MONDO:0021368 {source="MONDO:Redundant", source="NCIT:C4762"} ! neoplasm of major salivary gland +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001829 ! major salivary gland +property_value: exactMatch http://identifiers.org/snomedct/363378008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0496763 +property_value: exactMatch NCIT:C4762 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0044751 +name: chronic diarrheal disease +def: "Chronic form of diarrheal disease." [MONDO:patterns/chronic] +synonym: "chronic diarrhea" EXACT [] +synonym: "diarrheal disease, chronic" EXACT [MONDO:patterns/chronic] +xref: SCTID:236071009 {source="MONDO:equivalentTo"} +xref: UMLS:C0401151 {source="MONDO:equivalentTo"} +is_a: MONDO:0001673 ! diarrheal disease +intersection_of: MONDO:0001673 ! diarrheal disease +intersection_of: has_modifier PATO:0001863 ! chronic +relationship: has_modifier PATO:0001863 ! chronic +property_value: exactMatch http://identifiers.org/snomedct/236071009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0401151 + +[Term] +id: MONDO:0044764 +name: benign choroid plexus neoplasm +synonym: "benign choroid plexus neoplasm" EXACT [NCIT:C8405] +synonym: "benign choroid plexus neoplasms" EXACT [NCIT:C8405] +synonym: "benign choroid plexus tumor" EXACT [NCIT:C8405] +synonym: "benign choroid plexus tumors" EXACT [NCIT:C8405] +synonym: "benign neoplasm of choroid plexus" EXACT [NCIT:C8405] +synonym: "benign neoplasm of the choroid plexus" EXACT [NCIT:C8405] +synonym: "benign tumor of choroid plexus" EXACT [NCIT:C8405] +synonym: "benign tumor of the choroid plexus" EXACT [NCIT:C8405] +xref: NCIT:C8405 {source="MONDO:equivalentTo"} +xref: SCTID:254943007 {source="MONDO:equivalentTo"} +xref: UMLS:C0346290 {source="MONDO:equivalentTo"} +is_a: MONDO:0000629 ! cardiovascular organ benign neoplasm +is_a: MONDO:0016717 {source="NCIT:C8405"} ! choroid plexus neoplasm +is_a: MONDO:0020676 ! disorder of central nervous system or retinal vasculature +is_a: MONDO:0021451 {source="MONDO:Redundant", source="NCIT:C8405"} ! benign neoplasm of brain +is_a: MONDO:0024296 ! vascular neoplasm +is_a: MONDO:0043218 ! neurovascular disorder +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0001886 ! choroid plexus +relationship: disease_has_location UBERON:0001886 ! choroid plexus +property_value: exactMatch http://identifiers.org/snomedct/254943007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0346290 +property_value: exactMatch NCIT:C8405 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0044768 +name: vagus nerve paraganglioma +def: "A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the vagus nerve. Patients may present with a slow growing, painless mass in the neck, hoarseness, vocal cord paralysis, and dysphagia." [NCIT:C8427] +subset: gard_rare +synonym: "paraganglioma of the vagal body" EXACT [NCIT:C8427] +synonym: "paraganglioma of the vagus nerve" EXACT [NCIT:C8427] +synonym: "paraganglioma of vagal body" EXACT [NCIT:C8427] +synonym: "paraganglioma of vagus nerve" EXACT [NCIT:C8427] +synonym: "vagal body paraganglioma" EXACT [NCIT:C8427] +synonym: "vagal paraganglioma" EXACT [GARD:0008620, NCIT:C8427] +synonym: "vagus nerve paraganglioma" EXACT [MONDO:patterns/location, NCIT:C8427] +xref: EFO:1000621 {source="MONDO:equivalentTo"} +xref: GARD:0008620 {source="MONDO:equivalentTo"} +xref: NCIT:C8427 {source="MONDO:equivalentTo"} +xref: SCTID:253030004 {source="MONDO:equivalentTo"} +xref: UMLS:CN036786 {source="MONDO:equivalentTo"} +is_a: MONDO:0001608 {source="MONDO:Redundant", source="NCIT:C8427"} ! vagus nerve neoplasm +is_a: MONDO:0006239 ! head and neck paraganglioma +is_a: MONDO:0021052 {source="NCIT:C8427"} ! parasympathetic paraganglioma +intersection_of: MONDO:0000448 ! paraganglioma +intersection_of: disease_has_location UBERON:0001759 ! vagus nerve +property_value: exactMatch http://identifiers.org/snomedct/253030004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/CN036786 +property_value: exactMatch NCIT:C8427 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0044875 +name: coronary microvascular disorder +def: "A disorder affecting the smallest coronary arteries. Causes include atherosclerosis and arterial spasm. Chest pain is a frequently observed symptom." [NCIT:C84478] +synonym: "CMD" EXACT ABBREVIATION [NCIT:C84478] +synonym: "coronary microvascular disease" EXACT [NCIT:C84478] +synonym: "heart disease of microvascular endothelium" EXACT [] +synonym: "microvascular endothelium heart disease" EXACT [MONDO:patterns/location] +xref: NCIT:C84478 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 ! heart disorder +is_a: MONDO:0005385 ! vascular disorder +intersection_of: MONDO:0005267 ! heart disorder +intersection_of: disease_has_location UBERON:0008339 ! microvascular endothelium +relationship: disease_has_location UBERON:0008339 ! microvascular endothelium +property_value: exactMatch NCIT:C84478 + +[Term] +id: MONDO:0044877 +name: paraneoplastic cerebellar degeneration +def: "A rare, immune-mediated disorder characterized by cerebellar degeneration due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum. Signs and symptoms include progressive ataxia, dysarthria, and nystagmus." [NCIT:C4685] +synonym: "paraneoplastic cerebellar Degeneration" EXACT [NCIT:C4685] +xref: MESH:D020362 {source="MONDO:equivalentTo"} +xref: NCIT:C4685 {source="MONDO:equivalentTo"} +is_a: MONDO:0018215 ! paraneoplastic neurologic syndrome +is_a: MONDO:0022687 {source="MONDO:Redundant", source="NCIT:C4685"} ! cerebellar degeneration +intersection_of: MONDO:0021073 ! paraneoplastic syndrome +intersection_of: MONDO:0022687 ! cerebellar degeneration +property_value: exactMatch http://identifiers.org/mesh/D020362 +property_value: exactMatch NCIT:C4685 + +[Term] +id: MONDO:0044881 +name: hematopoietic and lymphoid cell neoplasm +def: "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes." [NCIT:C27134] +synonym: "hematologic cancer" EXACT [NCIT:C27134] +synonym: "hematologic malignancy" EXACT [NCIT:C27134] +synonym: "hematologic neoplasm" EXACT [NCIT:C27134] +synonym: "hematological neoplasm" EXACT [NCIT:C27134] +synonym: "hematological tumor" EXACT [NCIT:C27134] +synonym: "hematopoietic and lymphoid cell neoplasm" EXACT [NCIT:C27134] +synonym: "hematopoietic and lymphoid neoplasms" EXACT [NCIT:C27134] +synonym: "hematopoietic cancer" EXACT [NCIT:C27134] +synonym: "hematopoietic cell tumor" EXACT [NCIT:C27134] +synonym: "hematopoietic malignancy, NOS" EXACT [NCIT:C27134] +synonym: "hematopoietic neoplasm" EXACT [NCIT:C27134] +synonym: "hematopoietic neoplasms including lymphomas" EXACT [NCIT:C27134] +synonym: "hematopoietic tumor" EXACT [NCIT:C27134] +synonym: "hematopoietic, Including myeloma" EXACT [NCIT:C27134] +synonym: "HEMOLYMPHORETICULAR tumor, malignant" EXACT [NCIT:C27134] +synonym: "malignant hematologic neoplasm" EXACT [NCIT:C27134] +synonym: "malignant hematopoietic neoplasm" EXACT [NCIT:C27134] +xref: NCIT:C27134 {source="MONDO:equivalentTo"} +is_a: MONDO:0002334 {source="MONDO:Redundant", source="NCIT:C27134"} ! hematopoietic and lymphoid system neoplasm +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_arises_from_structure CL:0000988 ! hematopoietic cell +relationship: disease_arises_from_structure CL:0000988 ! hematopoietic cell +property_value: exactMatch NCIT:C27134 + +[Term] +id: MONDO:0044884 +name: tonsillar lymphoma +def: "A primary lymphoma that affects the tonsil and the bulk of the tumor is in this anatomic area. The majority of cases are B-cell non-Hodgkin lymphomas." [NCIT:C5918] +synonym: "lymphoma of the tonsil" EXACT [NCIT:C5918] +synonym: "lymphoma of tonsil" EXACT [NCIT:C5918] +synonym: "Primary tonsillar lymphoma" EXACT [NCIT:C5918] +synonym: "tonsil lymphoma" EXACT [MONDO:patterns/location, NCIT:C5918] +synonym: "tonsillar lymphoma" EXACT [NCIT:C5918] +xref: NCIT:C5918 {source="MONDO:equivalentTo"} +xref: UMLS:C1336765 {source="MONDO:equivalentTo"} +is_a: MONDO:0006998 {source="MONDO:Redundant", source="NCIT:C5918"} ! tonsil cancer +is_a: MONDO:0007650 ! MALT lymphoma +is_a: MONDO:0017128 ! inherited digestive tract tumor +is_a: MONDO:0018751 ! genetic otorhinolaryngologic disease +intersection_of: MONDO:0005062 ! lymphoma +intersection_of: disease_has_location UBERON:0002372 ! tonsil +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1336765 +property_value: exactMatch NCIT:C5918 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/lymphoma.yaml + +[Term] +id: MONDO:0044887 +name: central nervous system non-hodgkin lymphoma +def: "A non-Hodgkin lymphoma that arises from the central nervous system." [NCIT:C114779] +synonym: "Central nervous system non-Hodgkin lymphoma" EXACT [NCIT:C114779] +synonym: "central nervous system non-Hodgkin lymphoma" EXACT [MONDO:patterns/location] +synonym: "non-Hodgkin lymphoma of central nervous system" EXACT [MONDO:design_pattern] +synonym: "Primary Central nervous system non-Hodgkin lymphoma" EXACT [NCIT:C114779] +xref: NCIT:C114779 {source="MONDO:equivalentTo"} +xref: SCTID:448254007 {source="MONDO:equivalentTo"} +xref: UMLS:C2213246 {source="MONDO:equivalentTo"} +is_a: MONDO:0002571 {source="MONDO:Redundant", source="NCIT:C114779"} ! primary central nervous system lymphoma +is_a: MONDO:0015759 ! B-cell non-Hodgkin lymphoma +intersection_of: MONDO:0018908 ! non-Hodgkin lymphoma +intersection_of: disease_has_location UBERON:0001017 ! central nervous system +property_value: exactMatch http://identifiers.org/snomedct/448254007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2213246 +property_value: exactMatch NCIT:C114779 + +[Term] +id: MONDO:0044915 +name: salivary duct carcinoma +def: "An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites." [NCIT:C5904] +synonym: "carcinoma of duct of salivary gland" EXACT [MONDO:patterns/carcinoma] +synonym: "carcinoma of salivary duct" EXACT [NCIT:C5904] +synonym: "carcinoma of the salivary duct" EXACT [NCIT:C5904] +synonym: "duct of salivary gland carcinoma" EXACT [] +synonym: "high grade salivary duct carcinoma" EXACT [NCIT:C5904] +synonym: "salivary duct carcinoma" EXACT [NCIT:C5904] +xref: NCIT:C5904 {source="MONDO:equivalentTo"} +xref: ONCOTREE:SDCA {source="MONDO:equivalentTo"} +xref: UMLS:C1301194 {source="MONDO:equivalentTo"} +is_a: MONDO:0000521 ! salivary gland carcinoma +is_a: MONDO:0006176 {source="NCIT:C5904"} ! cribriform carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001837 ! duct of salivary gland +relationship: disease_has_location UBERON:0001837 ! duct of salivary gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1301194 +property_value: exactMatch NCIT:C5904 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0044919 +name: malignant renal pelvis neoplasm +def: "A primary or metastatic malignant neoplasm that affects the renal pelvis." [NCIT:C7525] +synonym: "cancer of renal pelvis" EXACT [MONDO:patterns/cancer] +synonym: "malignant neoplasm of renal pelvis" EXACT [MONDO:patterns/cancer, NCIT:C7525] +synonym: "malignant neoplasm of the renal pelvis" EXACT [NCIT:C7525] +synonym: "malignant renal pelvis neoplasm" EXACT [MONDO:patterns/cancer, NCIT:C7525] +synonym: "malignant renal pelvis tumor" EXACT [NCIT:C7525] +synonym: "malignant tumor of renal pelvis" EXACT [NCIT:C7525] +synonym: "malignant tumor of the renal pelvis" EXACT [NCIT:C7525] +synonym: "renal pelvis cancer" EXACT [] +xref: NCIT:C7525 {source="MONDO:equivalentTo"} +is_a: MONDO:0002367 {source="MONDO:Redundant", source="NCIT:C7525"} ! kidney cancer +is_a: MONDO:0003719 {source="MONDO:Redundant", source="NCIT:C7525"} ! renal pelvis neoplasm +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0001224 ! renal pelvis +property_value: exactMatch NCIT:C7525 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml + +[Term] +id: MONDO:0044925 +name: oral cavity carcinoma +def: "A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma." [NCIT:C8990] +synonym: "carcinoma of mouth" EXACT [NCIT:C8990] +synonym: "carcinoma of oral cavity" EXACT [MONDO:patterns/carcinoma, NCIT:C8990] +synonym: "carcinoma of the oral cavity" EXACT [NCIT:C8990] +synonym: "mouth carcinoma" EXACT [NCIT:C8990] +synonym: "oral cavity cancer" BROAD [NCIT:C8990] +synonym: "oral cavity carcinoma" EXACT [NCIT:C8990] +xref: NCIT:C8990 {source="MONDO:equivalentTo"} +xref: UMLS:C0151546 {source="MONDO:equivalentTo"} +is_a: MONDO:0005515 {source="MONDO:Redundant", source="NCIT:C8990"} ! oral cavity cancer +is_a: MONDO:0006181 ! digestive system carcinoma +is_a: MONDO:0023644 {source="NCIT:C8990"} ! lip and oral cavity carcinoma +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0000167 ! oral cavity +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0151546 +property_value: exactMatch NCIT:C8990 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0044926 +name: oropharyngeal carcinoma +def: "Carcinoma, predominantly squamous cell, arising from the epithelial cells of the oropharynx." [NCIT:C9105] +synonym: "cancer of oropharynx" BROAD [NCIT:C9105] +synonym: "cancer of the oropharynx" BROAD [NCIT:C9105] +synonym: "carcinoma of oropharynx" EXACT [MONDO:patterns/carcinoma, NCIT:C9105] +synonym: "carcinoma of the oropharynx" EXACT [NCIT:C9105] +synonym: "oropharyngeal cancer" BROAD [NCIT:C9105] +synonym: "oropharyngeal carcinoma" EXACT [NCIT:C9105] +synonym: "oropharyngeal throat cancer" BROAD [NCIT:C9105] +synonym: "oropharynx carcinoma" EXACT [NCIT:C9105] +xref: NCIT:C9105 {source="MONDO:equivalentTo"} +is_a: MONDO:0002038 ! head and neck carcinoma +is_a: MONDO:0004608 {source="MONDO:Redundant", source="NCIT:C9105"} ! oropharynx cancer +is_a: MONDO:0021345 {source="MONDO:Redundant", source="NCIT:C9105"} ! carcinoma of pharynx +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001729 ! oropharynx +property_value: exactMatch NCIT:C9105 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0044937 +name: rectal carcinoma +def: "A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas." [NCIT:C9382] +synonym: "cancer of rectum" BROAD [NCIT:C9382] +synonym: "cancer of the rectum" BROAD [NCIT:C9382] +synonym: "carcinoma of rectum" EXACT [MONDO:patterns/carcinoma, NCIT:C9382] +synonym: "carcinoma of the rectum" EXACT [NCIT:C9382] +synonym: "rectal cancer" BROAD [NCIT:C9382] +synonym: "rectal carcinoma" EXACT [NCIT:C9382] +synonym: "rectum carcinoma" EXACT [] +xref: NCIT:C9382 {source="MONDO:equivalentTo"} +is_a: MONDO:0006519 {source="MONDO:Redundant", source="NCIT:C9382"} ! rectal cancer +is_a: MONDO:0024331 {source="MONDO:Redundant", source="NCIT:C9382"} ! colorectal carcinoma +is_a: MONDO:0024476 ! epithelial neoplasm of rectum +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001052 ! rectum +property_value: exactMatch NCIT:C9382 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0044970 +name: mitochondrial disease +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_dysfunction_of GO:0005739 ! mitochondrion +relationship: disease_has_basis_in_dysfunction_of GO:0005739 ! mitochondrion +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_dysfunctional_structure.yaml + +[Term] +id: MONDO:0044972 +name: eosinophil disorder +def: "A disease or disorder that involves the eosinophil." [MONDO:design_pattern] +synonym: "disease of eosinophil" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of eosinophil" EXACT [] +synonym: "disorder of eosinophil" EXACT [MONDO:patterns/location_top] +synonym: "eosinophil disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: SCTID:417967008 {source="MONDO:equivalentTo"} +xref: UMLS:C1691020 {source="MONDO:equivalentTo"} +is_a: MONDO:0004805 {source="MONDO:Redundant"} ! leukocyte disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location CL:0000771 ! eosinophil +relationship: disease_has_location CL:0000771 ! eosinophil +property_value: exactMatch http://identifiers.org/snomedct/417967008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1691020 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044983 +name: benign lipomatous neoplasm +def: "A benign mesenchymal neoplasm composed of adipose (fatty) tissue. The most common representative of this category is the lipoma." [NCIT:C4502] +synonym: "adipose tissue benign connective and soft tissue neoplasm" EXACT [MONDO:design_pattern, MONDO:patterns/location] +synonym: "benign adipose tissue neoplasm" EXACT [NCIT:C4502] +synonym: "benign adipose tissue tumor" EXACT [NCIT:C4502] +synonym: "benign connective and soft tissue neoplasm of adipose tissue" EXACT [MONDO:design_pattern] +synonym: "benign lipomatous neoplasm" EXACT [NCIT:C4502] +synonym: "benign lipomatous tumor" EXACT [NCIT:C4502] +synonym: "benign neoplasm of adipose tissue" EXACT [NCIT:C4502] +synonym: "benign neoplasm of the adipose tissue" EXACT [NCIT:C4502] +synonym: "benign tumor of adipose tissue" RELATED [NCIT:C4502] +synonym: "benign tumor of the adipose tissue" EXACT [NCIT:C4502] +xref: NCIT:C4502 {source="MONDO:equivalentTo"} +is_a: MONDO:0000654 {source="MONDO:Redundant", source="NCIT:C4502"} ! benign connective and soft tissue neoplasm +is_a: MONDO:0021354 {source="MONDO:Redundant", source="NCIT:C4502"} ! tumor of adipose tissue +intersection_of: MONDO:0000654 ! benign connective and soft tissue neoplasm +intersection_of: disease_has_location UBERON:0001013 ! adipose tissue +property_value: exactMatch NCIT:C4502 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0044984 +name: nasolacrimal duct disorder +def: "A disease or disorder that involves the nasolacrimal duct." [MONDO:patterns/location] +synonym: "disease of nasolacrimal duct" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of nasolacrimal duct" EXACT [] +synonym: "disorder of nasolacrimal duct" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "nasolacrimal duct disease" EXACT [MONDO:design_pattern] +synonym: "nasolacrimal duct disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:95767006 {source="MONDO:equivalentTo"} +xref: UMLS:C0521744 {source="MONDO:equivalentTo"} +is_a: MONDO:0001854 ! lacrimal apparatus disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002392 ! nasolacrimal duct +relationship: disease_has_location UBERON:0002392 ! nasolacrimal duct +property_value: exactMatch http://identifiers.org/snomedct/95767006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0521744 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044986 +name: lymphoid system disorder +def: "A disease or disorder that involves the lymphoid system." [MONDO:patterns/location] +synonym: "disease of lymphoid system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of lymphoid system" EXACT [] +synonym: "disorder of lymphoid system" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "lymphoid system disease" EXACT [MONDO:design_pattern] +synonym: "lymphoid system disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:111590001 {source="MONDO:equivalentTo"} +is_a: MONDO:0005046 ! immune system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002465 ! lymphoid system +relationship: disease_has_location UBERON:0002465 ! lymphoid system +property_value: exactMatch http://identifiers.org/snomedct/111590001 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044991 +name: upper digestive tract disorder +def: "A disease or disorder that involves the upper digestive tract." [MONDO:patterns/location] +synonym: "disease of upper digestive tract" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of upper digestive tract" EXACT [] +synonym: "disorder of upper digestive tract" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disorder of upper gastrointestinal tract" EXACT [MONDO:design_pattern] +synonym: "upper digestive tract disease or disorder" EXACT [MONDO:patterns/location] +synonym: "upper gastrointestinal tract disease" EXACT [MONDO:design_pattern] +xref: SCTID:119291004 {source="MONDO:equivalentTo"} +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0004908 ! upper digestive tract +relationship: disease_has_location UBERON:0004908 ! upper digestive tract +property_value: exactMatch http://identifiers.org/snomedct/119291004 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044992 +name: mouth mucosa disorder +def: "A disease or disorder that involves the mouth mucosa." [MONDO:patterns/location] +synonym: "disease of mouth mucosa" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of mouth mucosa" EXACT [] +synonym: "disorder of mouth mucosa" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disorder of oral mucous membrane" EXACT [MONDO:design_pattern] +synonym: "mouth mucosa disease or disorder" EXACT [MONDO:patterns/location] +synonym: "oral mucous membrane disease" EXACT [MONDO:design_pattern] +xref: SCTID:128046007 {source="MONDO:equivalentTo"} +xref: UMLS:C1290071 {source="MONDO:equivalentTo"} +is_a: MONDO:0006858 ! mouth disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0003729 ! mouth mucosa +relationship: disease_has_location UBERON:0003729 ! mouth mucosa +property_value: exactMatch http://identifiers.org/snomedct/128046007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1290071 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044993 +name: sympathetic nervous system disorder +def: "A disease or disorder that involves the sympathetic nervous system." [MONDO:patterns/location] +synonym: "disease of sympathetic nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of sympathetic nervous system" EXACT [] +synonym: "disorder of sympathetic nervous system" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "sympathetic nervous system disease" EXACT [MONDO:design_pattern] +synonym: "sympathetic nervous system disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:50330009 {source="MONDO:equivalentTo"} +is_a: MONDO:0001292 ! autonomic nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000013 ! sympathetic nervous system +relationship: disease_has_location UBERON:0000013 ! sympathetic nervous system +property_value: exactMatch http://identifiers.org/snomedct/50330009 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044995 +name: parasympathetic nervous system disorder +def: "A disease or disorder that involves the parasympathetic nervous system." [MONDO:patterns/location] +synonym: "disease of parasympathetic nervous system" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of parasympathetic nervous system" EXACT [] +synonym: "disorder of parasympathetic nervous system" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "parasympathetic nervous system disease" EXACT [MONDO:design_pattern] +synonym: "parasympathetic nervous system disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:46091002 {source="MONDO:equivalentTo"} +is_a: MONDO:0001292 ! autonomic nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000011 ! parasympathetic nervous system +relationship: disease_has_location UBERON:0000011 ! parasympathetic nervous system +property_value: exactMatch http://identifiers.org/snomedct/46091002 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044996 +name: cerebral cortex disorder +def: "A disease or disorder that involves the cerebral cortex." [MONDO:patterns/location] +synonym: "cerebral cortex disease" EXACT [MONDO:design_pattern] +synonym: "cerebral cortex disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of cerebral cortex" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cerebral cortex" EXACT [] +synonym: "disorder of cerebral cortex" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +xref: SCTID:128128003 {source="MONDO:equivalentTo"} +xref: UMLS:C1263847 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000956 ! cerebral cortex +relationship: disease_has_location UBERON:0000956 ! cerebral cortex +property_value: exactMatch http://identifiers.org/snomedct/128128003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263847 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0044997 +name: midbrain disorder +def: "A disease or disorder that involves the midbrain." [MONDO:patterns/location] +synonym: "disease of midbrain" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of midbrain" EXACT [] +synonym: "disorder of midbrain" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "midbrain disease" EXACT [MONDO:design_pattern] +synonym: "midbrain disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:95641009 {source="MONDO:equivalentTo"} +xref: UMLS:C0521655 {source="MONDO:equivalentTo"} +is_a: MONDO:0005560 ! brain disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001891 ! midbrain +relationship: disease_has_location UBERON:0001891 ! midbrain +property_value: exactMatch http://identifiers.org/snomedct/95641009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0521655 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045001 +name: cardiac ventricle disorder +def: "A disease or disorder that involves the cardiac ventricle." [MONDO:patterns/location] +synonym: "cardiac ventricle disease" EXACT [MONDO:design_pattern] +synonym: "cardiac ventricle disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of cardiac ventricle" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of cardiac ventricle" EXACT [] +synonym: "disorder of cardiac ventricle" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +xref: SCTID:415991003 {source="MONDO:equivalentTo"} +xref: UMLS:C1562298 {source="MONDO:equivalentTo"} +is_a: MONDO:0005267 ! heart disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002082 ! cardiac ventricle +relationship: disease_has_location UBERON:0002082 ! cardiac ventricle +property_value: exactMatch http://identifiers.org/snomedct/415991003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1562298 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045002 +name: vertebral disorder +def: "A disease or disorder that involves the vertebra." [MONDO:patterns/location] +synonym: "disease of vertebra" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vertebra" EXACT [] +synonym: "disorder of vertebra" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "vertebra disease" EXACT [MONDO:design_pattern] +synonym: "vertebra disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:430886005 {source="MONDO:equivalentTo"} +xref: UMLS:C2316319 {source="MONDO:equivalentTo"} +is_a: MONDO:0000812 ! vertebral column disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0002412 ! vertebra +relationship: disease_has_location UBERON:0002412 ! vertebra +property_value: exactMatch http://identifiers.org/snomedct/430886005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C2316319 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045003 +name: scrotal disorder +def: "A disease or disorder that involves the scrotum." [MONDO:patterns/location] +synonym: "disease of scrotum" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of scrotum" EXACT [] +synonym: "disorder of scrotum" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "scrotum disease" EXACT [MONDO:design_pattern] +synonym: "scrotum disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:49701002 {source="MONDO:equivalentTo"} +xref: UMLS:C0268919 {source="MONDO:equivalentTo"} +is_a: MONDO:0003150 ! male reproductive system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001300 ! scrotum +relationship: disease_has_location UBERON:0001300 ! scrotum +property_value: exactMatch http://identifiers.org/snomedct/49701002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268919 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045004 +name: skeletal ligament disorder +def: "A disease or disorder that involves the skeletal ligament." [MONDO:patterns/location] +synonym: "disease of skeletal ligament" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of skeletal ligament" EXACT [] +synonym: "disorder of skeletal ligament" EXACT [MONDO:patterns/location_top] +synonym: "skeletal ligament disease or disorder" EXACT [MONDO:patterns/location] +is_a: MONDO:0005172 ! skeletal system disorder +is_a: MONDO:0045044 ! ligament disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0008846 ! skeletal ligament +relationship: disease_has_location UBERON:0008846 ! skeletal ligament +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045010 +name: glycoprotein metabolism disease +def: "A disease that has its basis in the disruption of glycoprotein metabolic process." [MONDO:design_pattern] +comment: Examples: alpha-n-acetylgalactosaminidase deficiency (disorder), carbohydrate-deficient glycoprotein syndrome (disorder), alpha-1-antitrypsin deficiency (disorder), alpha-2-antitrypsin deficiency (disorder), sialidosis (disorder), aspartylglucosaminuria (disorder), fucosidosis (disorder), mannosidosis (disorder), i-cell disease (disorder), glycoprotein storage disorder (disorder) +synonym: "disorder of glycoprotein metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of glycoprotein metabolism" EXACT [MONDO:design_pattern] +synonym: "glycoprotein metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "glycoprotein metabolism disease" EXACT [MONDO:design_pattern] +xref: SCTID:238045003 {source="MONDO:equivalentTo"} +xref: UMLS:C0342844 {source="MONDO:equivalentTo"} +is_a: MONDO:0019052 ! inborn errors of metabolism +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0009100 ! glycoprotein metabolic process +relationship: disease_has_basis_in_disruption_of GO:0009100 ! glycoprotein metabolic process +property_value: exactMatch http://identifiers.org/snomedct/238045003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0342844 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0045011 +name: keratinization disease +synonym: "disorder of keratinization" EXACT [MONDO:design_pattern] +synonym: "keratinization disease" EXACT [MONDO:design_pattern] +xref: SCTID:277905003 {source="MONDO:equivalentTo"} +xref: UMLS:C0475811 {source="MONDO:equivalentTo"} +is_a: MONDO:0002051 ! integumentary system disorder +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0031424 ! keratinization +relationship: disease_disrupts GO:0031424 ! keratinization +property_value: exactMatch http://identifiers.org/snomedct/277905003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0475811 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0045012 +name: steroid metabolism disease +def: "A disease that has its basis in the disruption of steroid metabolic process." [MONDO:design_pattern] +synonym: "disorder of steroid metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of steroid metabolism" EXACT [MONDO:design_pattern] +synonym: "steroid metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "steroid metabolism disease" EXACT [MONDO:design_pattern] +xref: SCTID:28710006 {source="MONDO:equivalentTo"} +xref: UMLS:C0268283 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0008202 ! steroid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0008202 ! steroid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/28710006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268283 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0045013 +name: disorder of extraembryonic membrane +def: "A disease or disorder that involves the extraembryonic membrane." [MONDO:patterns/location] +synonym: "disease of extraembryonic membrane" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of extraembryonic membrane" EXACT [] +synonym: "disorder of extraembryonic membrane" EXACT [MONDO:patterns/location_top] +synonym: "extraembryonic membrane disease" EXACT [] +synonym: "extraembryonic membrane disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:609522002 {source="MONDO:equivalentTo"} +xref: UMLS:C3662139 {source="MONDO:equivalentTo"} +is_a: MONDO:0005917 ! placenta disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0005631 ! extraembryonic membrane +relationship: disease_has_location UBERON:0005631 ! extraembryonic membrane +property_value: exactMatch http://identifiers.org/snomedct/609522002 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3662139 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045015 +name: carbohydrate transport disease +def: "A disease that has its basis in the disruption of carbohydrate transport." [MONDO:design_pattern] +synonym: "carbohydrate transport disease" EXACT [MONDO:design_pattern] +synonym: "disorder of carbohydrate transport" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +xref: SCTID:54905006 {source="MONDO:equivalentTo"} +xref: UMLS:C0268173 {source="MONDO:equivalentTo"} +is_a: MONDO:0037792 ! carbohydrate metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0008643 ! carbohydrate transport +relationship: disease_has_basis_in_disruption_of GO:0008643 ! carbohydrate transport +property_value: exactMatch http://identifiers.org/snomedct/54905006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268173 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0045019 +name: lactation disease +synonym: "disorder of lactation" EXACT [MONDO:design_pattern] +synonym: "lactation disease" EXACT [MONDO:design_pattern] +xref: SCTID:35046003 {source="MONDO:equivalentTo"} +xref: UMLS:C0022927 {source="MONDO:equivalentTo"} +is_a: MONDO:0002657 ! breast disorder +is_a: MONDO:0021147 ! disorder of development or morphogenesis +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0007595 ! lactation +relationship: disease_disrupts GO:0007595 ! lactation +property_value: exactMatch http://identifiers.org/snomedct/35046003 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0022927 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0045020 +name: glycine metabolism disease +def: "A disease that has its basis in the disruption of glycine metabolic process." [MONDO:design_pattern] +synonym: "disorder of glycine metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of glycine metabolism" EXACT [MONDO:design_pattern] +synonym: "glycine metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "glycine metabolism disease" EXACT [MONDO:design_pattern] +xref: SCTID:83076007 {source="MONDO:equivalentTo"} +xref: UMLS:C0268558 {source="MONDO:equivalentTo"} +is_a: MONDO:0037871 ! amino acid metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006544 ! glycine metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006544 ! glycine metabolic process +property_value: exactMatch http://identifiers.org/snomedct/83076007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0268558 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0045022 +name: disorder of organic acid metabolism +def: "A disease that has its basis in the disruption of organic acid metabolic process." [MONDO:design_pattern] +synonym: "disorder of organic acid metabolic process" EXACT [MONDO:design_pattern, MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of organic acid metabolism" EXACT [] +synonym: "organic acid metabolic process disease" EXACT [MONDO:design_pattern] +synonym: "organic acid metabolism disorder" EXACT [] +xref: ICD9:277.89 +xref: SCTID:116021002 {source="MONDO:equivalentTo"} +is_a: MONDO:0005066 {source="MONDO:Redundant"} ! metabolic disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006082 ! organic acid metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006082 ! organic acid metabolic process +property_value: exactMatch http://identifiers.org/snomedct/116021002 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0045024 +name: cancer or benign tumor +def: "Any disorder that features disrupted cell proliferation. Includes hyperplasia, neoplastic syndrome and isolated neoplasm diseases as well as precancerous conditions." [MONDO:cjm] +subset: harrisons_view +synonym: "cell proliferation disorder" EXACT [https://orcid.org/0000-0002-4142-7153] +synonym: "neoplasm" NARROW [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/neoplasm] +is_a: MONDO:0000001 ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0008283 ! cell population proliferation +union_of: MONDO:0005043 ! hyperplasia +union_of: MONDO:0021074 ! precancerous condition +union_of: MONDO:0023370 ! neoplastic disease or syndrome +union_of: MONDO:0045054 ! cancer-related condition +relationship: disease_disrupts GO:0008283 ! cell population proliferation +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml + +[Term] +id: MONDO:0045034 +name: infectious disease characteristic +is_a: MONDO:0021125 ! disease characteristic + +[Term] +id: MONDO:0045036 +name: primary infectious +def: "A characteristic of an infectious disease in which the disease affects an immunologically normal host." [https://www.ncbi.nlm.nih.gov/books/NBK7902] +is_a: MONDO:0045034 ! infectious disease characteristic + +[Term] +id: MONDO:0045043 +name: disorder of uterine broad ligament +def: "A disease or disorder that involves the broad ligament of uterus." [MONDO:patterns/location] +synonym: "broad ligament of uterus disease" EXACT [] +synonym: "broad ligament of uterus disease or disorder" EXACT [MONDO:patterns/location] +synonym: "disease of broad ligament of uterus" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of broad ligament of uterus" EXACT [] +synonym: "disorder of broad ligament" EXACT [] +synonym: "disorder of broad ligament of uterus" EXACT [MONDO:patterns/location_top] +xref: SCTID:237062006 {source="MONDO:equivalentTo"} +xref: UMLS:C0404479 {source="MONDO:equivalentTo"} +is_a: MONDO:0045044 ! ligament disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0012332 ! broad ligament of uterus +relationship: disease_has_location UBERON:0012332 ! broad ligament of uterus +property_value: exactMatch http://identifiers.org/snomedct/237062006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0404479 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045044 +name: ligament disorder +def: "A disease or disorder that involves the ligament." [MONDO:patterns/location] +synonym: "disease of ligament" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of ligament" EXACT [] +synonym: "disorder of ligament" EXACT [MONDO:patterns/location_top] +synonym: "ligament disease or disorder" EXACT [MONDO:patterns/location] +xref: SCTID:60492000 {source="MONDO:equivalentTo"} +xref: UMLS:C0263976 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 ! musculoskeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000211 ! ligament +relationship: disease_has_location UBERON:0000211 ! ligament +property_value: exactMatch http://identifiers.org/snomedct/60492000 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0263976 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0045046 +name: inherited thyroid metabolism disease +def: "An acquired metabolic disease that is has its basis in the disruption of thyroid hormone metabolic process." [MONDO:patterns/inborn_metabolic] +synonym: "inborn error of thyroid hormone metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +synonym: "inborn thyroid hormone metabolic process disorder" EXACT [] +synonym: "inherited disorder of thyroid metabolism" EXACT [] +synonym: "rare inborn error of thyroid hormone metabolic process" EXACT [MONDO:patterns/inborn_metabolic] +xref: ICD9:246.8 +xref: SCTID:36985004 {source="MONDO:equivalentTo"} +xref: UMLS:C0271824 {source="MONDO:equivalentTo"} +is_a: MONDO:0003240 ! thyroid gland disorder +is_a: MONDO:0019052 ! inborn errors of metabolism +intersection_of: MONDO:0019052 ! inborn errors of metabolism +intersection_of: disease_has_basis_in_disruption_of GO:0042403 ! thyroid hormone metabolic process +relationship: disease_has_basis_in_disruption_of GO:0042403 ! thyroid hormone metabolic process +property_value: exactMatch http://identifiers.org/snomedct/36985004 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0271824 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/inborn_metabolic_disrupts.yaml +property_value: http://purl.org/dc/terms/conformsTo inborn:metabolic.yaml + +[Term] +id: MONDO:0045050 +name: nuclear cataract +def: "A cataract (disease) that involves the lens nucleus." [MONDO:design_pattern] +synonym: "cataract (disease) of lens nucleus" EXACT [] +synonym: "lens nucleus cataract (disease)" EXACT [MONDO:patterns/location] +xref: HP:0100018 +xref: ICD9:366.04 +xref: SCTID:53889007 {source="MONDO:equivalentTo"} +is_a: MONDO:0005129 {source="MONDO:Redundant"} ! cataract +intersection_of: MONDO:0005129 ! cataract +intersection_of: disease_has_location UBERON:0000390 ! lens nucleus +relationship: disease_has_location UBERON:0000390 ! lens nucleus +property_value: exactMatch http://identifiers.org/snomedct/53889007 + +[Term] +id: MONDO:0045051 +name: cortical cataract +def: "A cataract (disease) that involves the lens cortex." [MONDO:patterns/location] +synonym: "cataract (disease) of lens cortex" EXACT [] +synonym: "lens cortex cataract (disease)" EXACT [MONDO:patterns/location] +xref: ICD9:366.03 +xref: SCTID:193576003 {source="MONDO:equivalentTo"} +is_a: MONDO:0005129 ! cataract +intersection_of: MONDO:0005129 ! cataract +intersection_of: disease_has_location UBERON:0000389 ! lens cortex +relationship: disease_has_location UBERON:0000389 ! lens cortex +property_value: exactMatch http://identifiers.org/snomedct/193576003 + +[Term] +id: MONDO:0045052 +name: benign osteogenic neoplasm +def: "A non-metastasizing bone-forming neoplasm. This category includes osteoma, osteoid osteoma, and osteoblastoma." [NCIT:C6602] +synonym: "benign osseous neoplasm" RELATED [NCIT:C6602] +synonym: "benign osseous tumor" RELATED [NCIT:C6602] +synonym: "benign osteogenic neoplasm" EXACT [NCIT:C6602] +synonym: "benign osteogenic tumor" EXACT [NCIT:C6602] +synonym: "osteogenic neoplasm, benign" EXACT [MONDO:patterns/benign] +xref: NCIT:C6602 {source="MONDO:equivalentTo"} +is_a: MONDO:0000654 {source="NCIT:C6602"} ! benign connective and soft tissue neoplasm +is_a: MONDO:0045053 {source="MONDO:Redundant", source="NCIT:C6602"} ! osteogenic neoplasm +intersection_of: MONDO:0045053 ! osteogenic neoplasm +intersection_of: has_modifier PATO:0002096 ! neoplastic, non-malignant +property_value: exactMatch NCIT:C6602 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/benign.yaml + +[Term] +id: MONDO:0045053 +name: osteogenic neoplasm +def: "A benign, intermediate, or malignant bone-forming neoplasm. Representative examples include osteoma, osteoblastoma, and osteosarcoma." [NCIT:C6603] +synonym: "osseous neoplasm" RELATED [NCIT:C6603] +synonym: "osseous tumor" RELATED [NCIT:C6603] +synonym: "osteogenic neoplasm" EXACT [NCIT:C6603] +synonym: "osteogenic tumor" EXACT [NCIT:C6603] +xref: NCIT:C6603 {source="MONDO:equivalentTo"} +is_a: MONDO:0002616 {source="MONDO:Redundant", source="NCIT:C6603"} ! mesenchymal cell neoplasm +intersection_of: MONDO:0002616 {source="NCIT:C6603"} ! mesenchymal cell neoplasm +intersection_of: disease_arises_from_structure CL:0000062 {source="NCIT:C6603"} ! osteoblast +relationship: disease_arises_from_structure CL:0000062 ! osteoblast +property_value: exactMatch NCIT:C6603 + +[Term] +id: MONDO:0045054 +name: cancer-related condition +def: "A disorder either associated with an increased risk for malignant transformation (e.g., intraepithelial neoplasia, leukoplakia, dysplastic nevus, myelodysplastic syndrome) or that develops as a result of the presence of an existing malignant neoplasm (e.g., paraneoplastic syndrome)." [NCIT:C8278] +synonym: "cancer related problem/condition" EXACT [NCIT:C8278] +synonym: "cancer-related condition" EXACT [NCIT:C8278] +synonym: "cancer-related problem or condition" EXACT [NCIT:C8278] +synonym: "oncologic complications" EXACT [NCIT:C8278] +synonym: "problem/condition, cancer related" EXACT [NCIT:C8278] +synonym: "problem/condition, cancer-related" EXACT [NCIT:C8278] +xref: NCIT:C8278 {source="MONDO:equivalentTo"} +xref: UMLS:C0280950 {source="MONDO:equivalentTo"} +is_a: MONDO:0045024 {source="MONDO:Redundant"} ! cancer or benign tumor +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0280950 +property_value: exactMatch NCIT:C8278 + +[Term] +id: MONDO:0045056 +name: grade II meningioma +def: "An atypical meningioma which may recur in approximately 29-40% of the cases. This category includes the atypical meningioma, chordoid meningioma, and clear cell meningioma." [NCIT:C38937] +synonym: "grade 2 meningioma" EXACT [NCIT:C38937] +synonym: "grade II meningioma" EXACT [NCIT:C38937] +synonym: "WHO grade II meningioma" EXACT [NCIT:C38937] +xref: NCIT:C38937 {source="MONDO:equivalentTo"} +xref: UMLS:C1512259 {source="MONDO:equivalentTo"} +is_a: MONDO:0016642 {source="MONDO:Redundant", source="NCIT:C38937"} ! meningioma +intersection_of: MONDO:0016642 {source="NCIT:C38937"} ! meningioma +intersection_of: has_modifier MONDO:0024492 {source="NCIT:C38937"} ! tumor grade 2, general grading system +relationship: has_modifier MONDO:0024492 {source="NCIT:C38937"} ! tumor grade 2, general grading system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1512259 +property_value: exactMatch NCIT:C38937 + +[Term] +id: MONDO:0045058 +name: ACTH-producing pituitary gland neoplasm +def: "An adenoma or carcinoma of the pituitary gland that produces corticotropin." [NCIT:C7909] +synonym: "ACTH producing pituitary gland neoplasm" EXACT [NCIT:C7909] +synonym: "ACTH-producing pituitary gland neoplasm" EXACT [NCIT:C7909] +synonym: "ACTH-producing pituitary neoplasm" EXACT [NCIT:C7909] +synonym: "ACTH-producing pituitary tumor" EXACT [NCIT:C7909] +synonym: "ACTH-secreting tumor of pituitary" EXACT [NCIT:C7909] +synonym: "ACTH-secreting tumor of the pituitary" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin producing pituitary gland tumor" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin secreting neoplasm of pituitary" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin secreting neoplasm of the pituitary" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin secreting pituitary gland tumor" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin secreting tumor of pituitary" EXACT [NCIT:C7909] +synonym: "adrenocorticotropin secreting tumor of the pituitary" EXACT [NCIT:C7909] +synonym: "corticotropin secreting pituitary gland neoplasm" EXACT [NCIT:C7909] +synonym: "pituitary corticotropin secreting neoplasm" EXACT [NCIT:C7909] +synonym: "pituitary corticotropin secreting tumor" EXACT [NCIT:C7909] +xref: NCIT:C7909 {source="MONDO:equivalentTo"} +xref: UMLS:C0278862 {source="MONDO:equivalentTo"} +is_a: MONDO:0017611 ! pituitary tumor +intersection_of: MONDO:0005070 ! neoplasm +intersection_of: disease_has_location UBERON:0000007 ! pituitary gland +intersection_of: realized_in GO:0051458 ! corticotropin secretion +relationship: realized_in GO:0051458 ! corticotropin secretion +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0278862 +property_value: exactMatch NCIT:C7909 + +[Term] +id: MONDO:0045059 +name: cribriform carcinoma of breast +synonym: "cribriform carcinoma" BROAD [] +synonym: "ductal carcinoma, cribriform type" EXACT [DOID:5675] +xref: DOID:5675 {source="MONDO:equivalentTo"} +is_a: MONDO:0004989 {source="DOID:5675", source="MONDO:Redundant"} ! breast carcinoma +is_a: MONDO:0006176 ! cribriform carcinoma +intersection_of: MONDO:0004989 ! breast carcinoma +intersection_of: disease_has_feature NCIT:C35920 ! Cribriform Pattern +property_value: exactMatch DOID:5675 + +[Term] +id: MONDO:0045069 +name: minor salivary gland carcinoma +def: "A carcinoma that arises from the minor salivary glands. Representative examples include adenoid cystic carcinoma, acinic cell carcinoma, polymorphous low grade adenocarcinoma, and mucinous adenocarcinoma." [NCIT:C5957] +synonym: "carcinoma of minor salivary gland" EXACT [MONDO:patterns/carcinoma, NCIT:C5957] +synonym: "carcinoma of the minor salivary gland" EXACT [NCIT:C5957] +synonym: "minor salivary gland cancer" EXACT [NCIT:C5957] +synonym: "minor salivary gland carcinoma" EXACT [NCIT:C5957] +xref: NCIT:C5957 {source="MONDO:equivalentTo"} +xref: UMLS:C1334771 {source="MONDO:equivalentTo", source="NCIT:C5957"} +is_a: MONDO:0000521 {source="MONDO:Redundant", source="NCIT:C5957"} ! salivary gland carcinoma +is_a: MONDO:0021316 {source="MONDO:Redundant", source="NCIT:C5957"} ! malignant tumor of minor salivary gland +intersection_of: MONDO:0004993 ! carcinoma +intersection_of: disease_has_location UBERON:0001830 ! minor salivary gland +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334771 +property_value: exactMatch NCIT:C5957 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/carcinoma.yaml + +[Term] +id: MONDO:0056798 +name: disorder of appendix +def: "A disease or disorder that involves the vermiform appendix." [MONDO:patterns/location] +synonym: "appendiceal disease" EXACT [] +synonym: "appendix disease" EXACT [] +synonym: "disease of appendix" EXACT [] +synonym: "disease of vermiform appendix" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of vermiform appendix" EXACT [] +synonym: "disorder of appendix" EXACT [] +synonym: "disorder of vermiform appendix" EXACT [MONDO:patterns/location_top] +synonym: "vermiform appendix disease" EXACT [] +synonym: "vermiform appendix disease or disorder" EXACT [MONDO:patterns/location] +xref: DOID:60000 {source="MONDO:equivalentTo"} +xref: ICD10CM:K35-K38 {source="https://github.com/monarch-initiative/mondo/issues/4536", source="MONDO:equivalentTo", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-4142-7153"} +xref: ICD9:543.9 +xref: SCTID:18526009 {source="MONDO:equivalentTo"} +xref: UMLS:C0267613 {source="MONDO:equivalentTo"} +is_a: MONDO:0024634 ! large intestine disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0001154 ! vermiform appendix +relationship: disease_has_location UBERON:0001154 ! vermiform appendix +property_value: exactMatch DOID:60000 +property_value: exactMatch http://identifiers.org/snomedct/18526009 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0267613 +property_value: exactMatch https://icd.codes/icd10cm/K35-K38 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0056799 +name: synovium disorder +def: "A disease or disorder that involves the layer of synovial tissue." [MONDO:patterns/location] +synonym: "disease of layer of synovial tissue" EXACT [MONDO:patterns/location_top] +synonym: "disease or disorder of layer of synovial tissue" EXACT [] +synonym: "disorder of layer of synovial tissue" EXACT [MONDO:patterns/location_top] +synonym: "disorder of synovium" EXACT [] +synonym: "layer of synovial tissue disease" EXACT [] +synonym: "layer of synovial tissue disease or disorder" EXACT [MONDO:patterns/location] +xref: ICD9:727.89 +xref: ICD9:727.9 +xref: SCTID:3519007 {source="MONDO:equivalentTo"} +xref: UMLS:C0263945 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 ! musculoskeletal system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0007616 ! layer of synovial tissue +relationship: disease_has_location UBERON:0007616 ! layer of synovial tissue +property_value: exactMatch http://identifiers.org/snomedct/3519007 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0263945 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0056803 +name: sulfur metabolism disease +def: "A disease that has its basis in the disruption of sulfur compound metabolic process." [MONDO:patterns/disrupts_process] +synonym: "disorder of sulfur compound metabolic process" EXACT [MONDO:patterns/basis_in_disruption_of_process] +synonym: "disorder of sulfur metabolic process" EXACT [] +synonym: "disorder of sulfur metabolism" EXACT [] +synonym: "disorder of sulphur metabolism" EXACT [] +synonym: "sulfur compound metabolic process disease" EXACT [] +xref: SCTID:123809005 {source="MONDO:equivalentTo"} +xref: UMLS:C1263724 {source="MONDO:equivalentTo"} +is_a: MONDO:0000226 ! mineral metabolism disease +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_basis_in_disruption_of GO:0006790 ! sulfur compound metabolic process +relationship: disease_has_basis_in_disruption_of GO:0006790 ! sulfur compound metabolic process +property_value: exactMatch http://identifiers.org/snomedct/123809005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1263724 +property_value: http://purl.org/dc/terms/conformsTo disrupts:process.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/basis_in_disruption_of_process.yaml + +[Term] +id: MONDO:0056804 +name: benign neoplasm of peripheral nervous system +xref: DOID:0080320 {source="MONDO:equivalentTo"} +is_a: MONDO:0000628 {source="DOID:0080320"} ! central nervous system organ benign neoplasm +is_a: MONDO:0001406 ! peripheral nervous system neoplasm +intersection_of: MONDO:0005165 ! benign neoplasm +intersection_of: disease_has_location UBERON:0000010 ! peripheral nervous system +property_value: exactMatch DOID:0080320 +property_value: http://purl.org/dc/terms/conformsTo benign:neoplasm.yaml + +[Term] +id: MONDO:0056806 +name: non-small cell squamous lung carcinoma +def: "A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma." [NCIT:C133254] +synonym: "non-small cell squamous lung cancer" EXACT [NCIT:C133254] +synonym: "non-small cell squamous lung carcinoma" EXACT [NCIT:C133254] +synonym: "squamous non-small cell lung carcinoma" EXACT [NCIT:C133254] +xref: DOID:0080521 {source="MONDO:equivalentTo"} +xref: NCIT:C133254 {source="MONDO:equivalentTo"} +xref: SCTID:723301009 {source="MONDO:equivalentTo"} +is_a: MONDO:0005097 {source="NCIT:C133254"} ! squamous cell lung carcinoma +is_a: MONDO:0005233 {source="NCIT:C133254"} ! non-small cell lung carcinoma +intersection_of: MONDO:0005097 {source="NCIT:C133254"} ! squamous cell lung carcinoma +intersection_of: MONDO:0005233 {source="NCIT:C133254"} ! non-small cell lung carcinoma +property_value: exactMatch DOID:0080521 +property_value: exactMatch http://identifiers.org/snomedct/723301009 +property_value: exactMatch NCIT:C133254 + +[Term] +id: MONDO:0056816 +name: vulvar neuroendocrine carcinoma +def: "A neuroendocrine carcinoma that arises from the vulva. This category includes small cell and large cell neuroendocrine carcinoma. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas." [NCIT:C128243] +synonym: "mammalian vulva neuroendocrine carcinoma" EXACT [MONDO:patterns/location] +synonym: "neuroendocrine carcinoma of mammalian vulva" EXACT [] +synonym: "vulvar high grade Neuroendocrine carcinoma" EXACT [NCIT:C128243] +synonym: "vulvar high grade Neuroendocrine neoplasm" EXACT [NCIT:C128243] +synonym: "vulvar Neuroendocrine cancer" EXACT [NCIT:C128243] +synonym: "vulvar Neuroendocrine carcinoma" EXACT [NCIT:C128243] +xref: NCIT:C128243 {source="MONDO:equivalentTo"} +xref: UMLS:C4288002 {source="MONDO:equivalentTo"} +is_a: MONDO:0002120 {source="NCIT:C128243"} ! neuroendocrine carcinoma +is_a: MONDO:0005215 {source="NCIT:C128243"} ! vulvar carcinoma +intersection_of: MONDO:0002120 ! neuroendocrine carcinoma +intersection_of: disease_has_location UBERON:0000997 ! mammalian vulva +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C4288002 +property_value: exactMatch NCIT:C128243 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml + +[Term] +id: MONDO:0056819 +name: nasal cavity and paranasal sinus carcinoma +def: "A carcinoma arising from the nasal cavity or paranasal sinuses." [NCIT:C54293] +comment: Editor note: TODO add uberon term +synonym: "nasal cavity and paranasal sinus cancer" EXACT [NCIT:C54293] +synonym: "nasal cavity and paranasal sinus carcinoma" EXACT [NCIT:C54293] +synonym: "paranasal sinus and nasal cavity cancer" EXACT [NCIT:C54293] +synonym: "sinonasal carcinoma" EXACT [NCIT:C54293] +xref: GARD:0007650 {source="MONDO:equivalentTo"} +xref: NCIT:C54293 {source="MONDO:equivalentTo"} +xref: UMLS:C1710095 {source="MONDO:equivalentTo"} +is_a: MONDO:0002038 {source="NCIT:C54293"} ! head and neck carcinoma +is_a: MONDO:0056820 {source="NCIT:C54293"} ! nasal cavity and paranasal sinus neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1710095 +property_value: exactMatch NCIT:C54293 +property_value: excluded_from_qc_check http://purl.obolibrary.org/obo/mondo/sparql/qc/general/qc-single-child.sparql + +[Term] +id: MONDO:0056820 +name: nasal cavity and paranasal sinus neoplasm +def: "A benign or malignant neoplasm that affects the nasal cavity or paranasal sinuses. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma." [NCIT:C7336] +comment: Editor note: TODO add uberon term +synonym: "nasal cavity and paranasal sinus neoplasm" EXACT [NCIT:C7336] +xref: NCIT:C7336 {source="MONDO:equivalentTo"} +xref: UMLS:C1334925 {source="MONDO:equivalentTo"} +is_a: MONDO:0005586 {source="NCIT:C7336"} ! head and neck neoplasm +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1334925 +property_value: exactMatch NCIT:C7336 + +[Term] +id: MONDO:0060782 +name: premalignant hematological system disease +def: "A hematologic disorder which does not display the morphologic and/or clinical characteristics of an overt malignancy. Representative examples include atypical lymphoproliferative disorders and myelodysplastic syndromes." [NCIT:C27274] +synonym: "premalignant hematologic condition" EXACT [NCIT:C27274] +xref: NCIT:C27274 {source="MONDO:equivalentTo"} +xref: UMLS:C1335471 {source="NCIT:C27274", source="MONDO:equivalentTo"} +is_a: MONDO:0005570 {source="NCIT:C27274"} ! hematologic disorder +is_a: MONDO:0021074 ! precancerous condition +intersection_of: MONDO:0021074 ! precancerous condition +intersection_of: disease_has_location UBERON:0002390 ! hematopoietic system +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C1335471 +property_value: exactMatch NCIT:C27274 + +[Term] +id: MONDO:0100010 +name: tendinopathy +def: "Disorders that are causes by overuse of tendons." [PMID:19188560] +synonym: "disease of tendon" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "disease or disorder of tendon" EXACT [] +synonym: "disorder of tendon" EXACT [MONDO:design_pattern, MONDO:patterns/location_top] +synonym: "tendon disease" EXACT [MONDO:design_pattern] +synonym: "tendon disease or disorder" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: EFO:1001434 {source="MONDO:equivalentTo"} +xref: SCTID:68172002 {source="MONDO:equivalentTo"} +is_a: MONDO:0002081 ! musculoskeletal system disorder +is_a: MONDO:0003900 {source="MONDO:Redundant"} ! connective tissue disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0000043 ! tendon +relationship: disease_has_location UBERON:0000043 ! tendon +property_value: exactMatch http://identifiers.org/snomedct/68172002 +property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-5208-3432 +property_value: http://purl.org/dc/elements/1.1/date 2018-07-17T15:51:39Z xsd:dateTime +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0100014 +name: autoimmune retinopathy +def: "An autoimmune disease characterized by sudden onset of photopsias and scotomata in patients with no family history of retinitis pigmentosa, followed by visual field and central vision loss." [PMID:29721944] +synonym: "AIR" EXACT ABBREVIATION [] +synonym: "autoimmune disease of retina" EXACT [MONDO:design_pattern] +synonym: "retina autoimmune disease" EXACT [MONDO:design_pattern, MONDO:patterns/location] +xref: GARD:0012034 {source="MONDO:equivalentTo"} +xref: SCTID:724809006 {source="MONDO:equivalentTo"} +xref: UMLS:C3203657 {source="MONDO:equivalentTo"} +is_a: MONDO:0000587 ! autoimmune disease of ear, nose and throat +is_a: MONDO:0002977 ! autoimmune disorder of the nervous system +is_a: MONDO:0005283 ! retinal disorder +intersection_of: MONDO:0007179 ! autoimmune disease +intersection_of: disease_has_location UBERON:0000966 ! retina +property_value: exactMatch http://identifiers.org/snomedct/724809006 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C3203657 +property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-5208-3432 +property_value: http://purl.org/dc/elements/1.1/date 2018-05-23T00:32:51Z xsd:dateTime + +[Term] +id: MONDO:0100033 +name: metabolic epilepsy +def: "Metabolic epilepsies are conceptualized as having a distinct metabolic abnormality that has been demonstrated to be associated with a substantially increased risk of developing epilepsy in appropriately designed studies. Metabolic disorders have genetic origin; however, the metabolic abnormalities are a separate disorder interposed between the genetic defect and the epilepsy." [https://orcid.org/0000-0001-8486-0558, https://www.epilepsydiagnosis.org/aetiology/metabolic-groupoverview.html] +is_a: MONDO:0005027 {source="https://orcid.org/0000-0001-8486-0558"} ! epilepsy +property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-5208-3432 +property_value: http://purl.org/dc/elements/1.1/date 2018-06-23T18:55:00Z xsd:dateTime + +[Term] +id: MONDO:0100035 +name: structural epilepsy +def: "Structural epilepsies are conceptualized as having a distinct structural brain abnormality that has been demonstrated to be associated with a substantially increased risk of epilepsy in appropriately designed studies. The structural brain abnormality can be acquired (such as due to stroke, trauma or infection) or may be of genetic origin; however, as we currently understand it, the structural brain abnormality is a separate disorder interposed between the acquired or genetic defect and the epilepsy." [https://orcid.org/0000-0001-8486-0558, https://www.epilepsydiagnosis.org/aetiology/structural-groupoverview.html] +is_a: MONDO:0005027 ! epilepsy +property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-5208-3432 +property_value: http://purl.org/dc/elements/1.1/date 2018-06-23T19:24:32Z xsd:dateTime + +[Term] +id: MONDO:0100070 +name: neuroendocrine disorder +def: "A disease or disorder that affects the neuroendocrine gland, any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli." [] +synonym: "neuroendocrine system disease" EXACT [] +is_a: MONDO:0005071 ! nervous system disorder +is_a: MONDO:0005151 ! endocrine system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_has_location UBERON:0010133 ! neuroendocrine gland +relationship: disease_has_location UBERON:0010133 ! neuroendocrine gland +property_value: http://purl.org/dc/elements/1.1/creator https://orcid.org/0000-0001-5208-3432 +property_value: http://purl.org/dc/elements/1.1/date 2018-12-17T22:24:52Z xsd:dateTime +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: http://purl.org/dc/terms/conformsTo location:top.yaml + +[Term] +id: MONDO:0100081 +name: sleep disorder +def: "A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep." [NCIT:C3376] +synonym: "disturbances, sleep" EXACT [NCIT:C3376] +synonym: "parasomnia" RELATED [NCIT:C3376] +synonym: "sleep disturbance" EXACT [NCIT:C3376] +synonym: "sleep disturbances" EXACT [NCIT:C3376] +xref: NCIT:C3376 {source="MONDO:equivalentTo"} +is_a: MONDO:0005071 ! nervous system disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: disease_disrupts GO:0030431 ! sleep +relationship: disease_disrupts GO:0030431 ! sleep +property_value: exactMatch NCIT:C3376 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_disease_by_disrupted_process.yaml +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100085 +name: cancer of long bone of upper limb +def: "A cancer that involves the upper limb long bone." [] +synonym: "cancer of fore limb long bone" EXACT [] +synonym: "cancer of long bone of fore limb" EXACT [] +synonym: "cancer of long bone of forelimb" EXACT [] +synonym: "cancer of long bone of upper extremity" EXACT [] +synonym: "cancer of upper extremity long bone" EXACT [] +synonym: "long bones of upper limb cancer" EXACT [] +synonym: "malignant neoplasm of upper limb long bone" EXACT [] +synonym: "malignant upper limb long bone neoplasm" EXACT [] +is_a: MONDO:0024311 ! cancer affecting bone of limb skeleton +intersection_of: MONDO:0004992 ! cancer +intersection_of: disease_has_location UBERON:0003607 ! forelimb long bone +relationship: disease_has_location UBERON:0003607 ! forelimb long bone +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/cancer.yaml +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100242 +name: glioma susceptibility +def: "An inherited susceptibility or predisposition to developing glioma." [OMIMPS:137800] +synonym: "glioma, susceptibility" EXACT [OMIMPS:137800] +synonym: "glioma, susceptibility to" EXACT [OMIMPS:137800] +xref: OMIM:607248 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613028 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613029 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613030 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613031 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613032 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIM:613033 {source="DOID:3070", source="Orphanet:182067", source="Orphanet:182067/btnt"} +xref: OMIMPS:137800 {source="MONDO:equivalentTo"} +is_a: MONDO:0020573 {source="OMIMPS:137800"} ! inherited disease susceptibility +intersection_of: MONDO:0020573 ! inherited disease susceptibility +intersection_of: predisposes_towards MONDO:0100342 ! malignant glioma +relationship: predisposes_towards MONDO:0100342 ! malignant glioma +property_value: exactMatch https://omim.org/phenotypicSeries/PS137800 +property_value: should_conform_to http://purl.obolibrary.org/obo/mondo/patterns/OMIM_phenotypic_series.yaml +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100308 +name: atactic disorder +def: "A central nervous system disease that consists of gait impairment, unclear (“scanning”) speech, visual blurring due to nystagmus, hand incoordination, and tremor with movement." [ISBN-13:978-1-259-64403-0] +synonym: "ataxia" RELATED [PMID:32965955] +synonym: "ataxic disorder" EXACT [ISBN-13:978-1-259-64403-0, PMID:32965955] +is_a: MONDO:0005071 {source="https://github.com/monarch-initiative/mondo/issues/3066", source="https://orcid.org/0000-0002-0736-9199"} ! nervous system disorder +intersection_of: MONDO:0005071 ! nervous system disorder +intersection_of: disease_has_major_feature HP:0001251 ! Ataxia +relationship: disease_has_major_feature HP:0001251 ! Ataxia +property_value: excluded_subClassOf MONDO:0002602 {source="ISBN-13:978-1-259-64403-0"} +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100309 +name: hereditary ataxia +def: "An instance of an atactic disorder that is caused by an inherited genomic modification in an individual." [MONDO:patterns/hereditary] +subset: disease_grouping +subset: gard_rare {source="GARD:0006614"} +subset: ordo_group_of_disorders {source="Orphanet:183518"} +synonym: "rare hereditary ataxia" EXACT [MONDO:0015956, Orphanet:183518] +synonym: "SCA" RELATED ABBREVIATION [GARD:0010748] +xref: DOID:0050951 {source="MONDO:equivalentTo"} +xref: GARD:0006614 {source="MONDO:equivalentTo"} +xref: GARD:0010748 {source="MONDO:equivalentTo"} +xref: ICD10CM:G11 {source="MONDO:equivalentTo"} +xref: MESH:C531684 {source="MONDO:equivalentTo"} +xref: Orphanet:183518 {source="MONDO:equivalentTo"} +xref: SCTID:763597000 {source="MONDO:equivalentTo"} +is_a: MONDO:0019117 ! genetic nervous system disorder +is_a: MONDO:0100308 {source="https://orcid.org/0000-0002-0736-9199"} ! atactic disorder +intersection_of: MONDO:0100308 ! atactic disorder +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch DOID:0050951 +property_value: exactMatch http://identifiers.org/mesh/C531684 +property_value: exactMatch http://identifiers.org/snomedct/763597000 +property_value: exactMatch https://icd.codes/icd10cm/G11 +property_value: exactMatch Orphanet:183518 +property_value: excluded_subClassOf MONDO:0000437 {source="Orphanet:183518"} +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/6614/hereditary-ataxia xsd:anyURI {source="GARD:0006614"} +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100310 +name: hereditary cerebellar ataxia +def: "Cerebellar ataxia that is transmitted from parent to child." [NCIT:C140268] +synonym: "cerebellar hereditary ataxia" EXACT [https://orcid.org/0000-0001-5208-3432] +synonym: "hereditary cerebellar ataxia" EXACT [NCIT:C140268] +xref: NCIT:C140268 {source="MONDO:equivalentTo"} +is_a: MONDO:0000437 {source="NCIT:C140268"} ! cerebellar ataxia +is_a: MONDO:0100309 ! hereditary ataxia +intersection_of: MONDO:0000437 ! cerebellar ataxia +intersection_of: has_modifier MONDO:0021152 ! inherited +property_value: exactMatch NCIT:C140268 +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100311 +name: sensory ataxia +def: "Any ataxia in which the causes of the disease is a perturbation of the sensory system, leading to its dysfunction." [MONDO:patterns/disease_by_dysfunctional_structure, PMID:32965955] +is_a: MONDO:0100308 {source="PMID:32965955"} ! atactic disorder +intersection_of: MONDO:0100308 ! atactic disorder +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0001032 ! sensory system +relationship: disease_has_basis_in_dysfunction_of UBERON:0001032 ! sensory system +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100312 +name: vestibular ataxia +def: "Any ataxia in which the causes of the disease is a perturbation of the vestibular system, leading to its dysfunction." [MONDO:patterns/disease_by_dysfunctional_structure, PMID:32965955] +is_a: MONDO:0100311 ! sensory ataxia +intersection_of: MONDO:0100308 ! atactic disorder +intersection_of: disease_has_basis_in_dysfunction_of UBERON:0004681 ! vestibular system +relationship: disease_has_basis_in_dysfunction_of UBERON:0004681 ! vestibular system +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100321 +name: viral disease or post-viral disorder +def: "A viral infectious disease that result from the presence and activity of a viral agent, or a disorder that follows infection with an viral agent but is distinct from the usual manifestations of the infection itself." [https://orcid.org/0000-0001-5208-3432] +subset: disease_grouping +synonym: "viral infectious disease or sequela" EXACT [https://github.com/monarch-initiative/mondo/issues/2950, https://orcid.org/0000-0001-5208-3432] +is_a: MONDO:0100336 {source="https://github.com/monarch-initiative/mondo/issues/2950", source="https://orcid.org/0000-0001-5208-3432"} ! infectious disease or post-infectious disorder +union_of: MONDO:0005108 ! viral infectious disease +union_of: MONDO:0021674 ! post-viral disorder +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100329 +name: primary viral infectious disease +def: "The initial viral infectious disase that causes illness." [https://medical-dictionary.thefreedictionary.com/primary+infection] +is_a: MONDO:0005108 {source="https://github.com/monarch-initiative/mondo/issues/2950", source="https://orcid.org/0000-0001-5208-3432"} ! viral infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +relationship: MONDO:0100332 NCBITaxon:10239 ! disease has primary infectious agent Viruses +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/2950 xsd:string +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100336 +name: infectious disease or post-infectious disorder +def: "A disease or disorder that result from the presence and activity of a microbial, viral, fungal or parasitic agent, or a disorder that follows infection with an infectious agent but is distinct from the usual manifestations of the infection itself." [https://orcid.org/0000-0001-5208-3432] +subset: disease_grouping +subset: harrisons_view +synonym: "infectious disease or sequela" EXACT [https://github.com/monarch-initiative/mondo/pull/3118#issuecomment-871858054, https://orcid.org/0000-0001-5208-3432] +is_a: MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/2950", source="https://orcid.org/0000-0001-5208-3432"} ! disease or disorder +union_of: MONDO:0005550 ! infectious disease +union_of: MONDO:0021669 ! post-infectious disorder +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100338 +name: urinary tract infection +synonym: "urinary tract infection (disease)" EXACT [https://orcid.org/0000-0002-6601-2165] +xref: MESH:D014552 {source="MONDO:equivalentTo"} +is_a: MONDO:0002118 ! urinary system disorder +is_a: MONDO:0005550 ! infectious disease +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_location UBERON:0001008 ! renal system +property_value: exactMatch http://identifiers.org/mesh/D014552 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/location.yaml +property_value: IAO:0000589 "urinary tract infection (disease)" xsd:string + +[Term] +id: MONDO:0100342 +name: malignant glioma +def: "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma." [NCIT:C4822] +subset: disease_grouping +subset: ordo_group_of_disorders {source="Orphanet:182067"} +synonym: "glial cell tumor" EXACT [DOID:3070] +synonym: "glioma" BROAD [Orphanet:182067] +synonym: "glioma, malignant" EXACT [DOID:3070, MONDO:patterns/malignant, NCIT:C4822] +synonym: "high grade glioma" EXACT [NCIT:C4822] +synonym: "high-grade glioma" EXACT [NCIT:C4822] +synonym: "malignant glial neoplasm" EXACT [NCIT:C4822] +synonym: "malignant glial tumor" EXACT [NCIT:C4822] +synonym: "malignant glioma" EXACT [NCIT:C4822] +synonym: "malignant neuroglial neoplasm" EXACT [NCIT:C4822] +synonym: "malignant neuroglial tumor" EXACT [DOID:3070, NCIT:C4822] +synonym: "neuroglial tumor" BROAD [DOID:3070, NCIT:C3059] +xref: DOID:3070 {source="MONDO:equivalentTo"} +xref: ICDO:9380/3 {source="NCIT:C4822"} +xref: KEGG:05214 {source="MONDO:relatedTo", source="DOID:3070"} +xref: MedDRA:10018338 {source="Orphanet:182067", source="Orphanet:182067/e"} +xref: NCIT:C4822 {source="MONDO:equivalentTo", source="DOID:3070"} +xref: UMLS:C0555198 {source="MONDO:equivalentTo", source="DOID:3070", source="NCIT:C4822"} +is_a: MONDO:0002714 {source="NCIT:C4822"} ! central nervous system cancer +is_a: MONDO:0020665 ! high grade malignant neoplasm +is_a: MONDO:0021042 {source="MONDO:Redundant", source="NCIT:C4822"} ! glioma +intersection_of: MONDO:0021042 ! glioma +intersection_of: has_modifier PATO:0002097 ! neoplastic, malignant +relationship: has_modifier MONDO:0021136 {source="MONDO:0016679"} ! rare +property_value: closeMatch http://identifiers.org/meddra/10018338 +property_value: exactMatch DOID:3070 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0555198 +property_value: exactMatch NCIT:C4822 +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/malignant.yaml +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100347 +name: carcinoid syndrome +subset: gard_rare {source="GARD:0005994"} +subset: ordo_clinical_syndrome {source="Orphanet:100093"} +synonym: "carcinoid syndrome" EXACT [MONDO:0006689, MONDO:0007262] +synonym: "carcinoid tumor syndrome" RELATED [GARD:0005994] +synonym: "carcinoid tumors, intestinal" RELATED [OMIM:114900] +synonym: "malignant carcinoid syndrome" EXACT [Orphanet:100093] +xref: EFO:1000852 {source="MONDO:equivalentTo"} +xref: GARD:0005994 {source="MONDO:equivalentTo"} +xref: ICD10CM:E34.0 {source="Orphanet:100093/e", source="MONDO:equivalentTo", source="EFO:1000852", source="Orphanet:100093"} +xref: ICD9:259.2 {source="MONDO:equivalentTo", source="MONDO:i2s", source="EFO:1000852"} +xref: MedDRA:10007270 {source="EFO:1000852"} +xref: NCIT:C3215 {source="MONDO:equivalentTo", source="EFO:1000852"} +xref: Orphanet:100093 {source="MONDO:equivalentTo", source="OMIM:114900"} +xref: SCTID:35868009 {source="MONDO:equivalentTo", source="EFO:1000852"} +is_a: MONDO:0002254 {source="MONDO:Redundant", source="NCIT:C3215/inferred"} ! syndromic disease +is_a: MONDO:0003847 ! Mendelian disease +intersection_of: MONDO:0002254 ! syndromic disease +intersection_of: disease_has_feature MONDO:0005369 ! carcinoid tumor +relationship: disease_has_feature MONDO:0005369 ! carcinoid tumor +relationship: has_material_basis_in_germline_mutation_in http://identifiers.org/hgnc/10683 {source="MONDO:mim2gene_medgen"} ! SDHD +property_value: closeMatch http://identifiers.org/meddra/10007270 +property_value: exactMatch http://identifiers.org/snomedct/35868009 +property_value: exactMatch https://icd.codes/icd10cm/E34.0 +property_value: exactMatch NCIT:C3215 +property_value: exactMatch Orphanet:100093 +property_value: excluded_subClassOf MONDO:0005369 {source="EFO:1000852"} +property_value: excluded_subClassOf MONDO:0015078 {source="Orphanet:100093"} +property_value: seeAlso https://rarediseases.info.nih.gov/diseases/5994/carcinoid-syndrome xsd:anyURI {source="GARD:0005994"} +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0100431 +name: migraine without aura +def: "A migraine disorder characterized by episodes that occur in the absence of preceding focal neurological symptoms." [NCIT:C117004] +synonym: "common migraine" EXACT [NCIT:C117004] +xref: DOID:12783 {source="MONDO:equivalentTo"} +xref: EFO:0005296 {source="MONDO:equivalentTo"} +xref: MESH:D020326 {source="MONDO:equivalentTo"} +xref: NCIT:C117004 {source="MONDO:equivalentTo"} +xref: SCTID:56097005 {source="MONDO:equivalentTo"} +xref: UMLS:C0338480 {source="MONDO:equivalentTo"} +is_a: MONDO:0005277 {source="https://orcid.org/0000-0001-7451-4467"} ! migraine disorder +property_value: exactMatch DOID:12783 +property_value: exactMatch http://identifiers.org/mesh/D020326 +property_value: exactMatch http://identifiers.org/snomedct/56097005 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0338480 +property_value: exactMatch NCIT:C117004 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3984 xsd:string +created_by: https://orcid.org/0000-0001-5208-3432 + +[Term] +id: MONDO:0600023 +name: idiopathic inflammatory myopathy +def: "Idiopathic form of inflammatory myopathy." [MONDO:patterns/idiopathic] +synonym: "idiopathic myositis" EXACT [https://orcid.org/0000-0001-5208-3432] +xref: NCIT:C116796 {source="MONDO:equivalentTo"} +xref: SCTID:702380008 {source="MONDO:equivalentTo"} +xref: UMLS:C0751356 {source="MONDO:equivalentTo"} +is_a: MONDO:0021167 ! myositis +property_value: exactMatch http://identifiers.org/snomedct/702380008 +property_value: exactMatch http://linkedlifedata.com/resource/umls/id/C0751356 +property_value: exactMatch NCIT:C116796 +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3143 xsd:string +created_by: https://orcid.org/0000-0002-5460-8025 + +[Term] +id: MONDO:0700003 +name: obstetric disorder +def: "Disorder associated with pregnancy, childbirth, and puerperium." [https://orcid.org/0000-0002-4142-7153] +subset: harrisons_view +is_a: MONDO:0000001 ! disease or disorder +union_of: MONDO:0024575 ! pregnancy disorder +union_of: MONDO:0044013 ! puerperal disorder +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/disease_or_disease_like.yaml +created_by: https://orcid.org/0000-0002-4142-7153 + +[Term] +id: MONDO:0700004 +name: idiopathic vs non-idiopathic +def: "A disease characteristic in which the cause of the disease is known or unknown." [https://github.com/monarch-initiative/mondo/issues/3177, https://orcid.org/0000-0002-4142-7153] +is_a: MONDO:0021125 {source="https://github.com/monarch-initiative/mondo/issues/3177", source="https://orcid.org/0000-0002-4142-7153"} ! disease characteristic +created_by: https://orcid.org/0000-0002-4142-7153 + +[Term] +id: MONDO:0700005 +name: idiopathic +def: "A disease characteristic in which the disease has an uncertain or unknown cause." [https://github.com/monarch-initiative/mondo/issues/3177, https://orcid.org/0000-0002-4142-7153] +is_a: MONDO:0700004 {source="https://github.com/monarch-initiative/mondo/issues/3177", source="https://orcid.org/0000-0002-4142-7153"} ! idiopathic vs non-idiopathic +created_by: https://orcid.org/0000-0002-4142-7153 + +[Term] +id: MONDO:0700007 +name: idiopathic disease +def: "A disease or disorder for which the cause is of uncertain or unknown." [https://orcid.org/0000-0002-4142-7153, MONDO:patterns/idiopathic] +synonym: "idiopathic disorder" EXACT [https://orcid.org/0000-0002-4142-7153] +is_a: MONDO:0000001 {source="https://github.com/monarch-initiative/mondo/issues/3169", source="https://orcid.org/0000-0002-4142-7153"} ! disease or disorder +intersection_of: MONDO:0000001 ! disease or disorder +intersection_of: has_modifier MONDO:0700005 ! idiopathic +relationship: has_modifier MONDO:0700005 ! idiopathic +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/idiopathic.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/3169 xsd:string +created_by: https://orcid.org/0000-0002-4142-7153 + +[Term] +id: MONDO:0700057 +name: neurological pain disorder +def: "A nervous system disorder that has pain as a major feature." [https://orcid.org/0000-0002-4142-7153] +synonym: "neurologic pain syndrome" EXACT [https://orcid.org/0000-0002-4142-7153] +synonym: "neurological pain disease" EXACT [https://orcid.org/0000-0002-4142-7153] +is_a: MONDO:0005071 {source="https://orcid.org/0000-0002-4142-7153"} ! nervous system disorder +intersection_of: MONDO:0005071 ! nervous system disorder +intersection_of: disease_has_major_feature HP:0012531 ! Pain +relationship: disease_has_major_feature HP:0012531 ! Pain +relationship: realized_in GO:0019233 {source="https://orcid.org/0000-0002-4142-7153"} ! sensory perception of pain +created_by: https://orcid.org/0000-0002-4142-7153 + +[Term] +id: MONDO:8000000 +name: infectious discitis +def: "An infection of the intervertebral disc space." [PMID:27070599] +is_a: MONDO:0037847 ! vertebral joint disorder +is_a: MONDO:0042485 ! infective arthritis +intersection_of: MONDO:0005550 ! infectious disease +intersection_of: disease_has_inflammation_site UBERON:0001066 ! intervertebral disk +relationship: disease_has_inflammation_site UBERON:0001066 ! intervertebral disk +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_infectious_disease_by_location.yaml +property_value: http://purl.org/dc/terms/conformsTo http://purl.obolibrary.org/obo/mondo/patterns/specific_inflammatory_disease_by_site.yaml +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/501 + +[Term] +id: MONDO:8000001 +name: staphylococcus discitis +def: "Discitis caused by infection with Staphylococcus." [PMID:27070599] +is_a: MONDO:0004471 ! bacterial arthritis +is_a: MONDO:0005545 ! staphylococcus aureus infection +is_a: MONDO:8000000 {source="PMID:27070599"} ! infectious discitis +intersection_of: MONDO:8000000 ! infectious discitis +intersection_of: disease_has_infectious_agent NCBITaxon:1280 ! Staphylococcus aureus +property_value: seeAlso https://github.com/monarch-initiative/mondo/issues/501 + +[Term] +id: MPATH:0 +name: pathological entity +def: "Pathological structure or process" [] +is_a: MPATH:1000 ! pathological phenotype observation + +[Term] +id: MPATH:1000 +name: pathological phenotype observation +def: "Phenotypic observation of the presence or absence of a pathological entity." [] + +[Term] +id: MPATH:603 +name: pathological anatomical entity +def: "Anatomically located instance of pathological response or entity." [] +is_a: MPATH:0 ! pathological entity + +[Term] +id: MPATH:607 +name: healing and repair structure +def: "Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage." [] +is_a: MPATH:603 ! pathological anatomical entity + +[Term] +id: MPATH:608 +name: abscess +def: "A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation." [] +is_a: MPATH:607 ! healing and repair structure + [Term] id: NBO:0000001 name: body part movement @@ -114353,6 +213161,16 @@ intersection_of: has_participant CHEBI:27958 ! cocaine relationship: has_participant CHEBI:27958 ! cocaine created_by: George Gkoutos +[Term] +id: NBO:0001952 +name: morphine consumption +def: "\"Behavior related to the intake of morphine.\" [NBOC:GVG]" [] +is_a: NBO:0001884 ! consumption of an addictive substance +intersection_of: NBO:0001884 ! consumption of an addictive substance +intersection_of: has_participant CHEBI:17303 ! morphine +relationship: has_participant CHEBI:17303 ! morphine +created_by: George Gkoutos + [Term] id: NBO:0001987 name: behavioral response to cocaine @@ -114363,6 +213181,37 @@ intersection_of: NBO:0001728 ! behavioral response to addictive substance intersection_of: in_response_to NBO:0001915 ! cocaine consumption relationship: in_response_to NBO:0001915 ! cocaine consumption +[Term] +id: NBO:0002021 +name: behavioral response to morphine +def: "\"Behavior as a result of sensitivity to morphine\" [NBOC:GVG]" [] +is_a: NBO:0001728 ! behavioral response to addictive substance +intersection_of: NBO:0001728 ! behavioral response to addictive substance +intersection_of: in_response_to NBO:0001952 ! morphine consumption +relationship: in_response_to NBO:0001952 ! morphine consumption +created_by: George Gkoutos + +[Term] +id: NBO:0002065 +name: behavioral response to nicotine +def: "\"Behavior as a result of sensitivity to nicotine intake.\" [NBOC:GVG]" [] +xref: GO:0035095 +is_a: NBO:0001728 ! behavioral response to addictive substance +intersection_of: NBO:0001728 ! behavioral response to addictive substance +intersection_of: in_response_to NBO:0002086 ! nicotine consumption +relationship: in_response_to NBO:0002086 ! nicotine consumption +created_by: George Gkoutos + +[Term] +id: NBO:0002086 +name: nicotine consumption +def: "\"Behavior related to the intake of nicotine.\" [NBOC:GVG]" [] +is_a: NBO:0001884 ! consumption of an addictive substance +intersection_of: NBO:0001884 ! consumption of an addictive substance +intersection_of: has_participant CHEBI:18723 ! nicotine +relationship: has_participant CHEBI:18723 ! nicotine +created_by: George Gkoutos + [Term] id: NBO:0002132 name: regulation of cocaine consumption @@ -114387,6 +213236,22 @@ is_a: NBO:0002169 ! regulation of consumption behavior relationship: regulates NBO:0001884 ! consumption of an addictive substance created_by: George Gkoutos +[Term] +id: NBO:0002273 +name: regulation of nicotine consumption +def: "\"Any process that modulates the frequency, rate or extent of nicotine consumption, the specific actions or reactions of an organism in response to external or internal stimuli.\" [NBOC:GVG]" [] +is_a: NBO:0002234 ! regulation of consumption of an addictive substance +relationship: regulates NBO:0002086 ! nicotine consumption +created_by: George Gkoutos + +[Term] +id: NBO:0002308 +name: regulation of morphine consumption +def: "\"Any process that modulates the frequency, rate or extent of morphine consumption, the specific actions or reactions of an organism in response to external or internal stimuli.\" [NBOC:GVG]" [] +is_a: NBO:0002234 ! regulation of consumption of an addictive substance +relationship: regulates NBO:0001952 ! morphine consumption +created_by: George Gkoutos + [Term] id: NBO:0002362 name: behavioral response to anesthetic @@ -114541,7 +213406,7 @@ name: root namespace: ncbi_taxonomy synonym: "all" RELATED synonym [] xref: GC_ID:1 -is_a: OBI:0100026 +is_a: OBI:0100026 ! organism [Term] id: NCBITaxon:10066 @@ -114574,6 +213439,42 @@ xref: GC_ID:1 is_a: NCBITaxon:862507 ! Mus property_value: has_rank NCBITaxon:species +[Term] +id: NCBITaxon:10239 +name: Viruses +namespace: ncbi_taxonomy +synonym: "Vira" RELATED synonym [] +synonym: "Viridae" RELATED synonym [] +synonym: "viruses" RELATED blast_name [] +xref: GC_ID:1 +is_a: NCBITaxon:1 ! root +property_value: has_rank NCBITaxon:superkingdom + +[Term] +id: NCBITaxon:10292 +name: Herpesviridae +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:548681 ! Herpesvirales +property_value: has_rank NCBITaxon:family + +[Term] +id: NCBITaxon:10293 +name: Alphaherpesvirinae +namespace: ncbi_taxonomy +synonym: "Alphaherpesviruses" EXACT common_name [] +xref: GC_ID:1 +is_a: NCBITaxon:10292 ! Herpesviridae +property_value: has_rank NCBITaxon:subfamily + +[Term] +id: NCBITaxon:10294 +name: Simplexvirus +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:10293 ! Alphaherpesvirinae +property_value: has_rank NCBITaxon:genus + [Term] id: NCBITaxon:117570 name: Teleostomi @@ -114591,6 +213492,7 @@ synonym: "bony vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:119089 @@ -114610,6 +213512,66 @@ xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia property_value: has_rank NCBITaxon:clade +[Term] +id: NCBITaxon:1239 +name: Firmicutes +namespace: ncbi_taxonomy +alt_id: NCBITaxon:31968 +synonym: "Bacillaeota" RELATED synonym [] +synonym: "Bacillota" RELATED synonym [] +synonym: "Bacillus/Clostridium group" RELATED synonym [] +synonym: "clostridial firmicutes" RELATED synonym [] +synonym: "Clostridium group firmicutes" RELATED synonym [] +synonym: "Firmacutes" RELATED synonym [] +synonym: "firmicutes" RELATED blast_name [] +synonym: "Low G+C firmicutes" RELATED synonym [] +synonym: "low G+C Gram-positive bacteria" EXACT common_name [] +synonym: "low GC Gram+" EXACT common_name [] +xref: GC_ID:11 +xref: PMID:10555317 +xref: PMID:11034484 +xref: PMID:11542017 +xref: PMID:15143038 +xref: PMID:25403554 +xref: PMID:26654112 +xref: PMID:29458499 +is_a: NCBITaxon:1783272 ! Terrabacteria group +property_value: has_rank NCBITaxon:phylum + +[Term] +id: NCBITaxon:1279 +name: Staphylococcus +namespace: ncbi_taxonomy +synonym: "Aurococcus" RELATED synonym [] +xref: GC_ID:11 +xref: PMID:10319469 +xref: PMID:10319495 +xref: PMID:10425778 +xref: PMID:10758876 +xref: PMID:12656157 +xref: PMID:17220435 +xref: PMID:9734063 +is_a: NCBITaxon:90964 ! Staphylococcaceae +property_value: has_rank NCBITaxon:genus + +[Term] +id: NCBITaxon:1280 +name: Staphylococcus aureus +namespace: ncbi_taxonomy +alt_id: NCBITaxon:325213 +alt_id: NCBITaxon:46170 +alt_id: NCBITaxon:72759 +synonym: "Micrococcus aureus" RELATED synonym [] +synonym: "Micrococcus pyogenes" RELATED synonym [] +synonym: "Staphlococcus pyogenes citreus" RELATED synonym [] +synonym: "Staphylococcus aureus subsp. anaerobius" RELATED synonym [] +synonym: "Staphylococcus pyogenes aureus" RELATED synonym [] +xref: GC_ID:11 +xref: PMID:31023808 +xref: PMID:8573498 +is_a: NCBITaxon:1279 ! Staphylococcus +property_value: has_rank NCBITaxon:species + [Term] id: NCBITaxon:131221 name: Streptophytina @@ -114647,6 +213609,16 @@ namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + +[Term] +id: NCBITaxon:1385 +name: Bacillales +namespace: ncbi_taxonomy +synonym: "Bacillus/Staphylococcus group" RELATED synonym [] +xref: GC_ID:11 +is_a: NCBITaxon:91061 ! Bacilli +property_value: has_rank NCBITaxon:order [Term] id: NCBITaxon:142796 @@ -114671,6 +213643,7 @@ xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:1437180 @@ -114698,6 +213671,75 @@ xref: GC_ID:1 is_a: NCBITaxon:451866 ! Taphrinomycotina property_value: has_rank NCBITaxon:class +[Term] +id: NCBITaxon:1760 +name: Actinomycetia +namespace: ncbi_taxonomy +alt_id: NCBITaxon:85003 +synonym: "Actinobacteria" RELATED synonym [] +synonym: "Actinomycetes" RELATED synonym [] +synonym: "high G+C Gram-positive bacteria" EXACT genbank_common_name [] +synonym: "high GC Gram+" RELATED blast_name [] +synonym: "High GC gram-positive bacteria" RELATED synonym [] +xref: GC_ID:11 +xref: PMID:10028260 +xref: PMID:11155976 +xref: PMID:11321122 +xref: PMID:19244447 +xref: PMID:28840812 +xref: PMID:30186281 +is_a: NCBITaxon:201174 ! Actinobacteria +property_value: has_rank NCBITaxon:class + +[Term] +id: NCBITaxon:1762 +name: Mycobacteriaceae +namespace: ncbi_taxonomy +xref: GC_ID:11 +xref: PMID:19244447 +xref: PMID:29497402 +xref: PMID:30186281 +is_a: NCBITaxon:85007 ! Corynebacteriales +property_value: has_rank NCBITaxon:family + +[Term] +id: NCBITaxon:1763 +name: Mycobacterium +namespace: ncbi_taxonomy +xref: GC_ID:11 +xref: PMID:1380284 +xref: PMID:1581193 +xref: PMID:16014496 +xref: PMID:1883713 +xref: PMID:2275850 +xref: PMID:29497402 +xref: PMID:31296783 +xref: PMID:7547284 +xref: PMID:7547304 +xref: PMID:7907223 +xref: PMID:8863452 +is_a: NCBITaxon:1762 ! Mycobacteriaceae +property_value: has_rank NCBITaxon:genus + +[Term] +id: NCBITaxon:1783272 +name: Terrabacteria group +namespace: ncbi_taxonomy +xref: GC_ID:11 +xref: PMID:18988685 +xref: PMID:23851394 +is_a: NCBITaxon:2 ! Bacteria +property_value: has_rank NCBITaxon:clade + +[Term] +id: NCBITaxon:1809 +name: Mycobacterium ulcerans +namespace: ncbi_taxonomy +xref: GC_ID:11 +xref: PMID:12089250 +is_a: NCBITaxon:1763 ! Mycobacterium +property_value: has_rank NCBITaxon:species + [Term] id: NCBITaxon:186623 name: Actinopteri @@ -114778,6 +213820,21 @@ xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms property_value: has_rank NCBITaxon:superkingdom +[Term] +id: NCBITaxon:201174 +name: Actinobacteria +namespace: ncbi_taxonomy +synonym: "Actinobacteraeota" RELATED synonym [] +synonym: "actinobacteria" RELATED blast_name [] +synonym: "Actinobacteriota" RELATED synonym [] +xref: GC_ID:11 +xref: PMID:11837318 +xref: PMID:16280504 +xref: PMID:26654112 +xref: PMID:29458499 +is_a: NCBITaxon:1783272 ! Terrabacteria group +property_value: has_rank NCBITaxon:phylum + [Term] id: NCBITaxon:2058185 name: Dictyosteliaceae @@ -114796,6 +213853,16 @@ xref: PMID:29367151 is_a: NCBITaxon:33083 ! Dictyostelia property_value: has_rank NCBITaxon:order +[Term] +id: NCBITaxon:207598 +name: Homininae +namespace: ncbi_taxonomy +synonym: "Homo/Pan/Gorilla group" RELATED synonym [] +xref: GC_ID:1 +is_a: NCBITaxon:9604 ! Hominidae +property_value: has_rank NCBITaxon:subfamily +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + [Term] id: NCBITaxon:2157 name: Archaea @@ -114880,6 +213947,38 @@ xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota property_value: has_rank NCBITaxon:clade +[Term] +id: NCBITaxon:2731341 +name: Duplodnaviria +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:10239 ! Viruses +property_value: has_rank NCBITaxon:clade + +[Term] +id: NCBITaxon:2731360 +name: Heunggongvirae +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2731341 ! Duplodnaviria +property_value: has_rank NCBITaxon:kingdom + +[Term] +id: NCBITaxon:2731361 +name: Peploviricota +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2731360 ! Heunggongvirae +property_value: has_rank NCBITaxon:phylum + +[Term] +id: NCBITaxon:2731363 +name: Herviviricetes +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2731361 ! Peploviricota +property_value: has_rank NCBITaxon:class + [Term] id: NCBITaxon:2759 name: Eukaryota @@ -114896,6 +213995,7 @@ xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms property_value: has_rank NCBITaxon:superkingdom +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:314146 @@ -114908,6 +214008,7 @@ xref: PMID:12878460 xref: PMID:15522813 is_a: NCBITaxon:1437010 ! Boreoeutheria property_value: has_rank NCBITaxon:superorder +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:314147 @@ -114921,6 +214022,26 @@ xref: PMID:15522813 is_a: NCBITaxon:314146 ! Euarchontoglires property_value: has_rank NCBITaxon:clade +[Term] +id: NCBITaxon:314293 +name: Simiiformes +namespace: ncbi_taxonomy +synonym: "Anthropoidea" RELATED synonym [] +xref: GC_ID:1 +is_a: NCBITaxon:376913 ! Haplorrhini +property_value: has_rank NCBITaxon:infraorder +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + +[Term] +id: NCBITaxon:314295 +name: Hominoidea +namespace: ncbi_taxonomy +synonym: "ape" EXACT common_name [] +synonym: "apes" EXACT genbank_common_name [] +xref: GC_ID:1 +is_a: NCBITaxon:9526 ! Catarrhini +property_value: has_rank NCBITaxon:superfamily + [Term] id: NCBITaxon:3193 name: Embryophyta @@ -114950,6 +214071,7 @@ synonym: "tetrapods" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:32524 @@ -114959,6 +214081,7 @@ synonym: "amniotes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:32525 @@ -114968,6 +214091,7 @@ synonym: "Theria" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:32561 @@ -115031,6 +214155,7 @@ synonym: "opisthokonts" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:33208 @@ -115051,6 +214176,7 @@ namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:33317 @@ -115068,6 +214194,7 @@ synonym: "deuterostomes" EXACT common_name [] xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:33630 @@ -115127,6 +214254,14 @@ xref: GC_ID:1 is_a: NCBITaxon:33090 ! Viridiplantae property_value: has_rank NCBITaxon:phylum +[Term] +id: NCBITaxon:376913 +name: Haplorrhini +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:9443 ! Primates +property_value: has_rank NCBITaxon:suborder + [Term] id: NCBITaxon:38254 name: Glaucocystophyceae @@ -115157,6 +214292,7 @@ synonym: "mammals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota property_value: has_rank NCBITaxon:class +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:41665 @@ -115227,7 +214363,7 @@ id: NCBITaxon:4751 name: Fungi namespace: ncbi_taxonomy synonym: "fungi" RELATED blast_name [] -synonym: "Mycota" RELATED genbank_synonym [] +synonym: "Mycota" RELATED synonym [] xref: GC_ID:1 xref: PMID:11062127 xref: PMID:12684019 @@ -115238,8 +214374,8 @@ property_value: has_rank NCBITaxon:kingdom id: NCBITaxon:4890 name: Ascomycota namespace: ncbi_taxonomy +synonym: "ascomycete fungi" RELATED blast_name [] synonym: "ascomycetes" EXACT genbank_common_name [] -synonym: "ascomycetes" RELATED blast_name [] synonym: "sac fungi" EXACT common_name [] xref: GC_ID:1 xref: PMID:17572334 @@ -115341,6 +214477,14 @@ xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda property_value: has_rank NCBITaxon:class +[Term] +id: NCBITaxon:548681 +name: Herpesvirales +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2731363 ! Herviviricetes +property_value: has_rank NCBITaxon:order + [Term] id: NCBITaxon:554915 name: Amoebozoa @@ -115404,6 +214548,7 @@ namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:6231 @@ -115476,6 +214621,16 @@ xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota property_value: has_rank NCBITaxon:clade +[Term] +id: NCBITaxon:7586 +name: Echinodermata +namespace: ncbi_taxonomy +synonym: "echinoderms" EXACT genbank_common_name [] +synonym: "echinoderms" RELATED blast_name [] +xref: GC_ID:1 +is_a: NCBITaxon:33511 ! Deuterostomia +property_value: has_rank NCBITaxon:phylum + [Term] id: NCBITaxon:7711 name: Chordata @@ -115485,9 +214640,11 @@ synonym: "chordates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia property_value: has_rank NCBITaxon:phylum +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:7742 +name: Vertebrata name: Vertebrata namespace: ncbi_taxonomy synonym: "Vertebrata" EXACT scientific_name [] @@ -115496,6 +214653,7 @@ synonym: "vertebrates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:7776 @@ -115504,8 +214662,9 @@ namespace: ncbi_taxonomy synonym: "Gnathostomata" EXACT scientific_name [] synonym: "jawed vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 -is_a: NCBITaxon:7742 ! Vertebrata +is_a: NCBITaxon:7742 ! Vertebrata property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:78536 @@ -115555,6 +214714,22 @@ xref: GC_ID:1 is_a: NCBITaxon:1329799 ! Archelosauria property_value: has_rank NCBITaxon:clade +[Term] +id: NCBITaxon:85007 +name: Corynebacteriales +namespace: ncbi_taxonomy +alt_id: NCBITaxon:1761 +synonym: "Corynebacterineae" RELATED synonym [] +synonym: "Mycobacteriales" RELATED synonym [] +xref: GC_ID:11 +xref: PMID:11837321 +xref: PMID:1736962 +xref: PMID:19244447 +xref: PMID:30186281 +xref: PMID:31157615 +is_a: NCBITaxon:1760 ! Actinomycetia +property_value: has_rank NCBITaxon:order + [Term] id: NCBITaxon:862507 name: Mus @@ -115592,6 +214767,25 @@ xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata property_value: has_rank NCBITaxon:subphylum +[Term] +id: NCBITaxon:90964 +name: Staphylococcaceae +namespace: ncbi_taxonomy +synonym: "Staphylococcus group" RELATED synonym [] +xref: GC_ID:11 +is_a: NCBITaxon:1385 ! Bacillales +property_value: has_rank NCBITaxon:family + +[Term] +id: NCBITaxon:91061 +name: Bacilli +namespace: ncbi_taxonomy +synonym: "Bacillus/Lactobacillus/Streptococcus group" RELATED synonym [] +synonym: "Firmibacteria" RELATED synonym [] +xref: GC_ID:11 +is_a: NCBITaxon:1239 ! Firmicutes +property_value: has_rank NCBITaxon:class + [Term] id: NCBITaxon:9347 name: Eutheria @@ -115604,6 +214798,59 @@ synonym: "placentals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32525 ! Theria property_value: has_rank NCBITaxon:clade +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + +[Term] +id: NCBITaxon:9443 +name: Primates +namespace: ncbi_taxonomy +synonym: "Primata" RELATED synonym [] +synonym: "primate" EXACT equivalent_name [] +synonym: "primates" RELATED blast_name [] +xref: GC_ID:1 +is_a: NCBITaxon:314146 ! Euarchontoglires +property_value: has_rank NCBITaxon:order +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + +[Term] +id: NCBITaxon:9526 +name: Catarrhini +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:314293 ! Simiiformes +property_value: has_rank NCBITaxon:parvorder +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl + +[Term] +id: NCBITaxon:9604 +name: Hominidae +namespace: ncbi_taxonomy +synonym: "great apes" EXACT genbank_common_name [] +synonym: "Pongidae" RELATED synonym [] +xref: GC_ID:1 +is_a: NCBITaxon:314295 ! Hominoidea +property_value: has_rank NCBITaxon:family + +[Term] +id: NCBITaxon:9605 +name: Homo +namespace: ncbi_taxonomy +synonym: "humans" EXACT common_name [] +xref: GC_ID:1 +is_a: NCBITaxon:207598 ! Homininae +property_value: has_rank NCBITaxon:genus + +[Term] +id: NCBITaxon:9606 +name: Homo sapiens +namespace: ncbi_taxonomy +synonym: "human" EXACT genbank_common_name [] +synonym: "man" EXACT common_name [] +xref: GC_ID:1 +is_a: FOODON:03411134 ! mammal +is_a: NCBITaxon:9605 ! Homo +property_value: has_rank NCBITaxon:species +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ncbitaxon.owl [Term] id: NCBITaxon:9989 @@ -115615,6 +214862,115 @@ xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires property_value: has_rank NCBITaxon:order +[Term] +id: NCIT:C125581 +name: Pathology Result +is_a: NCIT:C36292 ! Laboratory Test Result + +[Term] +id: NCIT:C16273 +name: Alcohol Consumption +def: "Consumption of liquids containing ethanol, including the behaviors associated with drinking the alcohol." [] +subset: NCIT:C156952 +subset: NCIT:C156953 +subset: NCIT:C156954 +subset: NCIT:C157529 +subset: NCIT:C157711 +subset: NCIT:C159106 +synonym: "Alcohol Consumption" EXACT [] +is_a: NCIT:C19683 ! Personal Behavior + +[Term] +id: NCIT:C16326 +name: Behavior +def: "The actions or reactions of an object or organism, usually in relation to the environment or surrounding world of stimuli." [] +subset: NCIT:C90259 +synonym: "Attitude" EXACT [] +synonym: "Behavior" EXACT [] +synonym: "Behavioral" EXACT [] +synonym: "Conduct" EXACT [] +is_a: NCIT:C43431 ! Activity +property_value: NCIT:A11 NCIT:C19988 +property_value: NCIT:P371 "Behavior" xsd:string + +[Term] +id: NCIT:C19683 +name: Personal Behavior +def: "The observable response of a person." [] +synonym: "Personal Behavior" EXACT [] +synonym: "Personal Conduct" EXACT [] +is_a: NCIT:C16326 ! Behavior + +[Term] +id: NCIT:C3367 +name: Finding +subset: NCIT:C116977 +subset: NCIT:C61410 +subset: NCIT:C67497 +subset: NCIT:C89506 +subset: NCIT:C90259 +is_a: NCIT:C7057 ! Disease, Disorder or Finding +property_value: NCIT:A11 NCIT:C90259 +property_value: NCIT:P371 "Finding" xsd:string + +[Term] +id: NCIT:C35867 +name: Morphologic Finding +subset: NCIT:C165451 +subset: NCIT:C166371 +subset: NCIT:C166372 +is_a: NCIT:C83490 ! Microscopic Finding + +[Term] +id: NCIT:C35886 +name: Morphologic Architectural Pattern +is_a: NCIT:C35867 ! Morphologic Finding + +[Term] +id: NCIT:C35920 +name: Cribriform Pattern +subset: NCIT:C120531 +subset: NCIT:C61410 +subset: NCIT:C77526 +is_a: NCIT:C35886 ! Morphologic Architectural Pattern + +[Term] +id: NCIT:C36292 +name: Laboratory Test Result +subset: NCIT:C116977 +subset: NCIT:C118169 +subset: NCIT:C54447 +subset: NCIT:C89506 +subset: NCIT:C90259 +is_a: NCIT:C77140 ! Clinical Test Result +property_value: NCIT:A11 NCIT:C3367 +property_value: NCIT:P371 "Laboratory Test Result" xsd:string + +[Term] +id: NCIT:C43431 +name: Activity +def: "An active process; excludes processes and mechanisms which fulfill biological functions." [] +subset: NCIT:C105551 +subset: NCIT:C159501 +subset: NCIT:C159503 +synonym: "Activity" EXACT [] +synonym: "General activity" EXACT [] +disjoint_from: NCIT:C7057 ! Disease, Disorder or Finding + +[Term] +id: NCIT:C7057 +name: Disease, Disorder or Finding + +[Term] +id: NCIT:C77140 +name: Clinical Test Result +is_a: NCIT:C3367 ! Finding + +[Term] +id: NCIT:C83490 +name: Microscopic Finding +is_a: NCIT:C125581 ! Pathology Result + [Term] id: OBA:0000001 name: biological attribute @@ -115642,7 +214998,7 @@ synonym: "diameter of Malpighian tubule" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000007 ! Malpighian tubule size is_a: OBA:0000171 ! tube diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0001054 ! Malpighian tubule +intersection_of: RO:0000052 UBERON:0001054 ! inheres in Malpighian tubule [Term] id: OBA:0000007 @@ -115651,8 +215007,8 @@ def: "The size of a Malpighian tubule." [AUTO:patterns/patterns/entity_attribute synonym: "size of Malpighian tubule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001054 ! Malpighian tubule -relationship: inheres_in UBERON:0001054 ! Malpighian tubule +intersection_of: RO:0000052 UBERON:0001054 ! inheres in Malpighian tubule +relationship: RO:0000052 UBERON:0001054 ! inheres in Malpighian tubule [Term] id: OBA:0000009 @@ -115661,8 +215017,8 @@ def: "The macromolecular stability of a RNA." [AUTO:patterns/patterns/entity_att synonym: "macromolecular stability of RNA" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0001001 ! macromolecular stability intersection_of: OBA:0001001 ! macromolecular stability -intersection_of: inheres_in SO:0000356 ! RNA -relationship: inheres_in SO:0000356 ! RNA +intersection_of: RO:0000052 SO:0000356 ! inheres in RNA +relationship: RO:0000052 SO:0000356 ! inheres in RNA [Term] id: OBA:0000011 @@ -115672,8 +215028,8 @@ synonym: "length of actin filament" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000057 ! cellular component size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005884 ! actin filament -relationship: inheres_in GO:0005884 ! actin filament +intersection_of: RO:0000052 GO:0005884 ! inheres in actin filament +relationship: RO:0000052 GO:0005884 ! inheres in actin filament [Term] id: OBA:0000015 @@ -115683,8 +215039,8 @@ synonym: "size of anatomical structure" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000061 ! anatomical structure -relationship: inheres_in UBERON:0000061 ! anatomical structure +intersection_of: RO:0000052 UBERON:0000061 ! inheres in anatomical structure +relationship: RO:0000052 UBERON:0000061 ! inheres in anatomical structure [Term] id: OBA:0000016 @@ -115701,8 +215057,8 @@ def: "The quality of a hunger motivation behavior." [AUTO:patterns/patterns/enti synonym: "quality of hunger motivation behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000235 ! hunger motivation behavior -relationship: inheres_in NBO:0000235 ! hunger motivation behavior +intersection_of: RO:0000052 NBO:0000235 ! inheres in hunger motivation behavior +relationship: RO:0000052 NBO:0000235 ! inheres in hunger motivation behavior [Term] id: OBA:0000022 @@ -115712,8 +215068,8 @@ synonym: "size of autophagosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005776 ! autophagosome -relationship: inheres_in GO:0005776 ! autophagosome +intersection_of: RO:0000052 GO:0005776 ! inheres in autophagosome +relationship: RO:0000052 GO:0005776 ! inheres in autophagosome [Term] id: OBA:0000023 @@ -115723,7 +215079,7 @@ synonym: "diameter of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003797 ! axon size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon [Term] id: OBA:0000032 @@ -115733,29 +215089,26 @@ synonym: "size of blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:0000036 name: body fluid levels -def: "The volume when measured in multicellular organism." [AUTO:patterns/patterns/attribute_location] -synonym: "multicellular organism volume" EXACT [AUTO:patterns/patterns/attribute_location] -is_a: OBA:VT0100005 ! body size trait +def: "The volume of a bodily fluid." [AUTO:patterns/patterns/entity_attribute] +synonym: "volume of bodily fluid" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0006314 ! inheres in bodily fluid +relationship: RO:0000052 UBERON:0006314 ! inheres in bodily fluid [Term] id: OBA:0000037 -name: obsolete brood size -is_a: OBA:0000001 ! biological attribute is_obsolete: true replaced_by: PATO:0000276 [Term] id: OBA:0000039 -name: obsolete buoyancy -is_a: OBA:0000001 ! biological attribute is_obsolete: true replaced_by: PATO:0001420 @@ -115767,8 +215120,8 @@ synonym: "concentration of of calcium ion" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000033 ! concentration of intersection_of: PATO:0000033 ! concentration of -intersection_of: inheres_in CHEBI:39124 ! calcium ion -relationship: inheres_in CHEBI:39124 ! calcium ion +intersection_of: RO:0000052 CHEBI:39124 ! inheres in calcium ion +relationship: RO:0000052 CHEBI:39124 ! inheres in calcium ion [Term] id: OBA:0000046 @@ -115778,8 +215131,8 @@ synonym: "membrane potential of cardiac muscle cell" EXACT [AUTO:patterns/patter is_a: OBA:0000099 ! membrane potential is_a: OBA:1000076 ! attribute of cell intersection_of: OBA:0000099 ! membrane potential -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell -relationship: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell +relationship: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:0000048 @@ -115789,7 +215142,7 @@ synonym: "diameter of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0000050 @@ -115803,8 +215156,8 @@ def: "The size of a cell projection." [AUTO:patterns/patterns/entity_attribute] synonym: "size of cell projection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0042995 ! cell projection -relationship: inheres_in GO:0042995 ! cell projection +intersection_of: RO:0000052 GO:0042995 ! inheres in cell projection +relationship: RO:0000052 GO:0042995 ! inheres in cell projection [Term] id: OBA:0000052 @@ -115814,7 +215167,7 @@ synonym: "shape of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0000055 @@ -115824,7 +215177,7 @@ synonym: "size of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0000056 @@ -115834,7 +215187,7 @@ synonym: "volume of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0000057 @@ -115844,7 +215197,7 @@ synonym: "size of cellular_component" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005575 ! cellular_component +intersection_of: RO:0000052 GO:0005575 ! inheres in cellular_component [Term] id: OBA:0000058 @@ -115854,7 +215207,7 @@ synonym: "cell acidity" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001842 ! acidity intersection_of: PATO:0001842 ! acidity -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0000060 @@ -115865,8 +215218,8 @@ synonym: "frequency of cilium movement" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0003341 ! cilium movement -relationship: inheres_in GO:0003341 ! cilium movement +intersection_of: RO:0000052 GO:0003341 ! inheres in cilium movement +relationship: RO:0000052 GO:0003341 ! inheres in cilium movement [Term] id: OBA:0000061 @@ -115876,8 +215229,8 @@ synonym: "amount of fibrinogen complex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005577 ! fibrinogen complex -relationship: inheres_in GO:0005577 ! fibrinogen complex +intersection_of: RO:0000052 GO:0005577 ! inheres in fibrinogen complex +relationship: RO:0000052 GO:0005577 ! inheres in fibrinogen complex [Term] id: OBA:0000066 @@ -115888,8 +215241,8 @@ is_a: OBA:0000052 ! cell shape is_a: OBA:VT0100007 ! growth trait is_a: PATO:0000039 ! direction intersection_of: PATO:0000039 ! direction -intersection_of: inheres_in GO:0016049 ! cell growth -relationship: inheres_in GO:0016049 ! cell growth +intersection_of: RO:0000052 GO:0016049 ! inheres in cell growth +relationship: RO:0000052 GO:0016049 ! inheres in cell growth [Term] id: OBA:0000067 @@ -115898,8 +215251,8 @@ def: "The shape of a embryonic cell (metazoa)." [AUTO:patterns/patterns/entity_a synonym: "shape of embryonic cell (metazoa)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000052 ! cell shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in CL:0002321 ! embryonic cell (metazoa) -relationship: inheres_in CL:0002321 ! embryonic cell (metazoa) +intersection_of: RO:0000052 CL:0002321 ! inheres in embryonic cell (metazoa) +relationship: RO:0000052 CL:0002321 ! inheres in embryonic cell (metazoa) [Term] id: OBA:0000068 @@ -115908,8 +215261,8 @@ def: "The size of a endosome." [AUTO:patterns/patterns/entity_attribute] synonym: "size of endosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000142 ! vesicle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005768 ! endosome -relationship: inheres_in GO:0005768 ! endosome +intersection_of: RO:0000052 GO:0005768 ! inheres in endosome +relationship: RO:0000052 GO:0005768 ! inheres in endosome [Term] id: OBA:0000069 @@ -115919,17 +215272,16 @@ is_a: OBA:0000125 ! post-synaptic membrane potential [Term] id: OBA:0000072 name: follicle cell microvillus length -def: "The microvillus length of a ovarian follicle cell." [AUTO:patterns/patterns/entity_attribute] -synonym: "microvillus length of ovarian follicle cell" EXACT [AUTO:patterns/patterns/entity_attribute] +def: "The microvillus length of a follicle cell of egg chamber." [AUTO:patterns/patterns/entity_attribute] +synonym: "microvillus length of follicle cell of egg chamber" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:0000102 ! microvillus length intersection_of: OBA:0000102 ! microvillus length -intersection_of: inheres_in CL:0000477 ! ovarian follicle cell -relationship: inheres_in CL:0000477 ! ovarian follicle cell +intersection_of: RO:0000052 CL:0000477 ! inheres in follicle cell of egg chamber +relationship: RO:0000052 CL:0000477 ! inheres in follicle cell of egg chamber [Term] id: OBA:0000074 -is_a: OBA:0000001 ! biological attribute is_obsolete: true replaced_by: OBA:1001087 @@ -115950,8 +215302,8 @@ synonym: "size of imaginal disc-derived wing" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015071 ! appendage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000984 ! imaginal disc-derived wing -relationship: inheres_in UBERON:0000984 ! imaginal disc-derived wing +intersection_of: RO:0000052 UBERON:0000984 ! inheres in imaginal disc-derived wing +relationship: RO:0000052 UBERON:0000984 ! inheres in imaginal disc-derived wing [Term] id: OBA:0000085 @@ -115966,8 +215318,8 @@ synonym: "surface tension of liquid configuration" EXACT [AUTO:patterns/patterns is_a: OBA:0000001 {is_asserted="true"} ! biological attribute is_a: PATO:0001461 ! surface tension intersection_of: PATO:0001461 ! surface tension -intersection_of: inheres_in PATO:0001735 ! liquid configuration -relationship: inheres_in PATO:0001735 ! liquid configuration +intersection_of: RO:0000052 PATO:0001735 ! inheres in liquid configuration +relationship: RO:0000052 PATO:0001735 ! inheres in liquid configuration [Term] id: OBA:0000089 @@ -115989,8 +215341,8 @@ synonym: "lysosomal lumen acidity" EXACT [AUTO:patterns/patterns/attribute_locat is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0001842 ! acidity intersection_of: PATO:0001842 ! acidity -intersection_of: inheres_in GO:0043202 ! lysosomal lumen -relationship: inheres_in GO:0043202 ! lysosomal lumen +intersection_of: RO:0000052 GO:0043202 ! inheres in lysosomal lumen +relationship: RO:0000052 GO:0043202 ! inheres in lysosomal lumen [Term] id: OBA:0000092 @@ -115999,8 +215351,8 @@ def: "The permeability of a lysosomal membrane." [AUTO:patterns/patterns/entity_ synonym: "permeability of lysosomal membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000028 ! membrane permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in GO:0005765 ! lysosomal membrane -relationship: inheres_in GO:0005765 ! lysosomal membrane +intersection_of: RO:0000052 GO:0005765 ! inheres in lysosomal membrane +relationship: RO:0000052 GO:0005765 ! inheres in lysosomal membrane [Term] id: OBA:0000093 @@ -116009,8 +215361,8 @@ def: "The macromolecular stability of a mRNA." [AUTO:patterns/patterns/entity_at synonym: "macromolecular stability of mRNA" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000009 ! RNA stability intersection_of: OBA:0001001 ! macromolecular stability -intersection_of: inheres_in SO:0000234 ! mRNA -relationship: inheres_in SO:0000234 ! mRNA +intersection_of: RO:0000052 SO:0000234 ! inheres in mRNA +relationship: RO:0000052 SO:0000234 ! inheres in mRNA [Term] id: OBA:0000098 @@ -116028,7 +215380,7 @@ synonym: "electric potential of membrane" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000090 ! membrane quality is_a: PATO:0001464 ! electric potential intersection_of: PATO:0001464 ! electric potential -intersection_of: inheres_in GO:0016020 ! membrane +intersection_of: RO:0000052 GO:0016020 ! inheres in membrane [Term] id: OBA:0000100 @@ -116038,8 +215390,8 @@ synonym: "membrane potential of photoreceptor cell" EXACT [AUTO:patterns/pattern is_a: OBA:0000099 ! membrane potential is_a: OBA:1000076 ! attribute of cell intersection_of: OBA:0000099 ! membrane potential -intersection_of: inheres_in CL:0000210 ! photoreceptor cell -relationship: inheres_in CL:0000210 ! photoreceptor cell +intersection_of: RO:0000052 CL:0000210 ! inheres in photoreceptor cell +relationship: RO:0000052 CL:0000210 ! inheres in photoreceptor cell [Term] id: OBA:0000101 @@ -116049,7 +215401,7 @@ synonym: "size of metanephros" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005425 ! metanephros morphology is_a: OBA:VT0002706 ! kidney size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000081 ! metanephros +intersection_of: RO:0000052 UBERON:0000081 ! inheres in metanephros [Term] id: OBA:0000102 @@ -116059,8 +215411,8 @@ synonym: "length of microvillus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000051 ! cell projection size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005902 ! microvillus -relationship: inheres_in GO:0005902 ! microvillus +intersection_of: RO:0000052 GO:0005902 ! inheres in microvillus +relationship: RO:0000052 GO:0005902 ! inheres in microvillus [Term] id: OBA:0000103 @@ -116076,8 +215428,8 @@ def: "The permeability of a mitochondrial membrane." [AUTO:patterns/patterns/ent synonym: "permeability of mitochondrial membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000028 ! membrane permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in GO:0031966 ! mitochondrial membrane -relationship: inheres_in GO:0031966 ! mitochondrial membrane +intersection_of: RO:0000052 GO:0031966 ! inheres in mitochondrial membrane +relationship: RO:0000052 GO:0031966 ! inheres in mitochondrial membrane [Term] id: OBA:0000105 @@ -116087,8 +215439,8 @@ synonym: "membrane potential of mitochondrial membrane" EXACT [AUTO:patterns/pat is_a: OBA:0000099 ! membrane potential is_a: PATO:0001462 ! membrane potential intersection_of: PATO:0001462 ! membrane potential -intersection_of: inheres_in GO:0031966 ! mitochondrial membrane -relationship: inheres_in GO:0031966 ! mitochondrial membrane +intersection_of: RO:0000052 GO:0031966 ! inheres in mitochondrial membrane +relationship: RO:0000052 GO:0031966 ! inheres in mitochondrial membrane [Term] id: OBA:0000106 @@ -116104,8 +215456,8 @@ def: "The size of a multivesicular body." [AUTO:patterns/patterns/entity_attribu synonym: "size of multivesicular body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000068 ! endosome size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005771 ! multivesicular body -relationship: inheres_in GO:0005771 ! multivesicular body +intersection_of: RO:0000052 GO:0005771 ! inheres in multivesicular body +relationship: RO:0000052 GO:0005771 ! inheres in multivesicular body [Term] id: OBA:0000110 @@ -116115,8 +215467,8 @@ synonym: "speed of muscle filament sliding" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000008 ! speed intersection_of: PATO:0000008 ! speed -intersection_of: inheres_in GO:0030049 ! muscle filament sliding -relationship: inheres_in GO:0030049 ! muscle filament sliding +intersection_of: RO:0000052 GO:0030049 ! inheres in muscle filament sliding +relationship: RO:0000052 GO:0030049 ! inheres in muscle filament sliding [Term] id: OBA:0000112 @@ -116126,8 +215478,8 @@ synonym: "amount of myofibril" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0030016 ! myofibril -relationship: inheres_in GO:0030016 ! myofibril +intersection_of: RO:0000052 GO:0030016 ! inheres in myofibril +relationship: RO:0000052 GO:0030016 ! inheres in myofibril [Term] id: OBA:0000113 @@ -116137,8 +215489,8 @@ synonym: "size of myofibril" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0030016 ! myofibril -relationship: inheres_in GO:0030016 ! myofibril +intersection_of: RO:0000052 GO:0030016 ! inheres in myofibril +relationship: RO:0000052 GO:0030016 ! inheres in myofibril [Term] id: OBA:0000114 @@ -116148,8 +215500,8 @@ synonym: "synaptic plasticity of neuron" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000141 ! synaptic plasticity is_a: OBA:1000076 ! attribute of cell intersection_of: OBA:0000141 ! synaptic plasticity -intersection_of: inheres_in CL:0000540 ! neuron -relationship: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron +relationship: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:0000116 @@ -116159,8 +215511,8 @@ synonym: "amount of http://purl.obolibrary.org/obo/GOCHE_25512" EXACT [AUTO:patt is_a: OBA:0100004 {is_asserted="true"} ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GOCHE:25512 -relationship: inheres_in GOCHE:25512 +intersection_of: RO:0000052 GOCHE:25512 ! inheres in +relationship: RO:0000052 GOCHE:25512 ! inheres in [Term] id: OBA:0000117 @@ -116170,7 +215522,7 @@ synonym: "size of nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:1000019 ! nucleus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus [Term] id: OBA:0000119 @@ -116180,8 +215532,8 @@ synonym: "amount of nucleosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0000786 ! nucleosome -relationship: inheres_in GO:0000786 ! nucleosome +intersection_of: RO:0000052 GO:0000786 ! inheres in nucleosome +relationship: RO:0000052 GO:0000786 ! inheres in nucleosome [Term] id: OBA:0000120 @@ -116193,8 +215545,8 @@ xref: Wikipedia:Osmotic_pressure is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:15377 ! water -relationship: inheres_in CHEBI:15377 ! water +intersection_of: RO:0000052 CHEBI:15377 ! inheres in water +relationship: RO:0000052 CHEBI:15377 ! inheres in water [Term] id: OBA:0000121 @@ -116210,7 +215562,7 @@ synonym: "size of peroxisome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:0005997 ! peroxisome morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005777 ! peroxisome +intersection_of: RO:0000052 GO:0005777 ! inheres in peroxisome [Term] id: OBA:0000123 @@ -116226,8 +215578,8 @@ def: "The size of a post-lysosomal vacuole." [AUTO:patterns/patterns/entity_attr synonym: "size of post-lysosomal vacuole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000142 ! vesicle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0032195 ! post-lysosomal vacuole -relationship: inheres_in GO:0032195 ! post-lysosomal vacuole +intersection_of: RO:0000052 GO:0032195 ! inheres in post-lysosomal vacuole +relationship: RO:0000052 GO:0032195 ! inheres in post-lysosomal vacuole [Term] id: OBA:0000125 @@ -116237,8 +215589,8 @@ synonym: "membrane potential of postsynaptic membrane" EXACT [AUTO:patterns/patt is_a: OBA:0000099 ! membrane potential is_a: PATO:0001462 ! membrane potential intersection_of: PATO:0001462 ! membrane potential -intersection_of: inheres_in GO:0045211 ! postsynaptic membrane -relationship: inheres_in GO:0045211 ! postsynaptic membrane +intersection_of: RO:0000052 GO:0045211 ! inheres in postsynaptic membrane +relationship: RO:0000052 GO:0045211 ! inheres in postsynaptic membrane [Term] id: OBA:0000126 @@ -116248,8 +215600,8 @@ synonym: "concentration of of potassium(1+)" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000033 ! concentration of intersection_of: PATO:0000033 ! concentration of -intersection_of: inheres_in CHEBI:29103 ! potassium(1+) -relationship: inheres_in CHEBI:29103 ! potassium(1+) +intersection_of: RO:0000052 CHEBI:29103 ! inheres in potassium(1+) +relationship: RO:0000052 CHEBI:29103 ! inheres in potassium(1+) [Term] id: OBA:0000127 @@ -116258,8 +215610,8 @@ def: "The size of a pronephros." [AUTO:patterns/patterns/entity_attribute] synonym: "size of pronephros" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002706 ! kidney size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002120 ! pronephros -relationship: inheres_in UBERON:0002120 ! pronephros +intersection_of: RO:0000052 UBERON:0002120 ! inheres in pronephros +relationship: RO:0000052 UBERON:0002120 ! inheres in pronephros [Term] id: OBA:0000128 @@ -116270,7 +215622,7 @@ synonym: "macromolecular stability of protein" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0001001 ! macromolecular stability is_a: OBA:0100005 ! protein attribute intersection_of: OBA:0001001 ! macromolecular stability -intersection_of: inheres_in PR:000000001 ! protein +intersection_of: RO:0000052 PR:000000001 ! inheres in protein [Term] id: OBA:0000129 @@ -116279,8 +215631,8 @@ def: "The macromolecular stability of a rRNA." [AUTO:patterns/patterns/entity_at synonym: "macromolecular stability of rRNA" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0001001 ! macromolecular stability intersection_of: OBA:0001001 ! macromolecular stability -intersection_of: inheres_in SO:0000252 ! rRNA -relationship: inheres_in SO:0000252 ! rRNA +intersection_of: RO:0000052 SO:0000252 ! inheres in rRNA +relationship: RO:0000052 SO:0000252 ! inheres in rRNA [Term] id: OBA:0000134 @@ -116300,8 +215652,8 @@ synonym: "amount of spindle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005819 ! spindle -relationship: inheres_in GO:0005819 ! spindle +intersection_of: RO:0000052 GO:0005819 ! inheres in spindle +relationship: RO:0000052 GO:0005819 ! inheres in spindle [Term] id: OBA:0000139 @@ -116310,8 +215662,8 @@ def: "The quality of a synapse." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045202 ! synapse -relationship: inheres_in GO:0045202 ! synapse +intersection_of: RO:0000052 GO:0045202 ! inheres in synapse +relationship: RO:0000052 GO:0045202 ! inheres in synapse [Term] id: OBA:0000140 @@ -116340,7 +215692,7 @@ synonym: "size of dorsal plus ventral thalamus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000832 ! thalamus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001897 ! dorsal plus ventral thalamus +intersection_of: RO:0000052 UBERON:0001897 ! inheres in dorsal plus ventral thalamus [Term] id: OBA:0000161 @@ -116351,8 +215703,8 @@ synonym: "the force of heart contraction" EXACT [] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001035 ! force intersection_of: PATO:0001035 ! force -intersection_of: inheres_in GO:0060047 ! heart contraction -relationship: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction +relationship: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:0000164 @@ -116365,8 +215717,8 @@ synonym: "velocity of shortening of skeletal muscle" RELATED [] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000008 ! speed intersection_of: PATO:0000008 ! speed -intersection_of: inheres_in GO:0003009 ! skeletal muscle contraction -relationship: inheres_in GO:0003009 ! skeletal muscle contraction +intersection_of: RO:0000052 GO:0003009 ! inheres in skeletal muscle contraction +relationship: RO:0000052 GO:0003009 ! inheres in skeletal muscle contraction [Term] id: OBA:0000166 @@ -116376,7 +215728,7 @@ synonym: "diameter of respiratory tube" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000168 ! tracheal tube size is_a: OBA:0000171 ! tube diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0000117 ! respiratory tube +intersection_of: RO:0000052 UBERON:0000117 ! inheres in respiratory tube [Term] id: OBA:0000167 @@ -116386,7 +215738,7 @@ synonym: "length of respiratory tube" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000168 ! tracheal tube size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000117 ! respiratory tube +intersection_of: RO:0000052 UBERON:0000117 ! inheres in respiratory tube [Term] id: OBA:0000168 @@ -116396,7 +215748,7 @@ synonym: "size of respiratory tube" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000172 ! tube size is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000117 ! respiratory tube +intersection_of: RO:0000052 UBERON:0000117 ! inheres in respiratory tube [Term] id: OBA:0000169 @@ -116407,8 +215759,8 @@ synonym: "translational fidelity" EXACT [GO:0006450] is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0006412 ! translation -relationship: inheres_in GO:0006412 ! translation +intersection_of: RO:0000052 GO:0006412 ! inheres in translation +relationship: RO:0000052 GO:0006412 ! inheres in translation [Term] id: OBA:0000171 @@ -116418,7 +215770,7 @@ synonym: "diameter of tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0000025 ! tube +intersection_of: RO:0000052 UBERON:0000025 ! inheres in tube [Term] id: OBA:0000172 @@ -116427,8 +215779,8 @@ def: "The size of a tube." [AUTO:patterns/patterns/entity_attribute] synonym: "size of tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000025 ! tube -relationship: inheres_in UBERON:0000025 ! tube +intersection_of: RO:0000052 UBERON:0000025 ! inheres in tube +relationship: RO:0000052 UBERON:0000025 ! inheres in tube [Term] id: OBA:0000173 @@ -116438,7 +215790,7 @@ synonym: "volume of urine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000036 ! body fluid levels is_a: OBA:VT0000056 ! urine trait intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:0000174 @@ -116448,8 +215800,8 @@ synonym: "permeability of vessel" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000970 ! permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in UBERON:0000055 ! vessel -relationship: inheres_in UBERON:0000055 ! vessel +intersection_of: RO:0000052 UBERON:0000055 ! inheres in vessel +relationship: RO:0000052 UBERON:0000055 ! inheres in vessel [Term] id: OBA:0000181 @@ -116472,7 +215824,7 @@ synonym: "diameter of blood vessel" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000032 ! blood vessel size is_a: OBA:0000171 ! tube diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:0001001 @@ -116488,7 +215840,7 @@ synonym: "structure of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002135 ! kidney morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0002001 @@ -116498,7 +215850,7 @@ synonym: "size of lower urinary tract" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000275 ! lower urinary tract quality is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001556 ! lower urinary tract +intersection_of: RO:0000052 UBERON:0001556 ! inheres in lower urinary tract [Term] id: OBA:0002002 @@ -116508,7 +215860,7 @@ synonym: "displaced of testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000107 ! testis position is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:0002003 @@ -116518,7 +215870,7 @@ synonym: "phenotypic sex of multicellular organism" EXACT [AUTO:patterns/pattern is_a: OBA:1001089 ! multicellular organism sex is_a: PATO:0001894 ! phenotypic sex intersection_of: PATO:0001894 ! phenotypic sex -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0002004 @@ -116528,8 +215880,8 @@ synonym: "displaced of urethral meatus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0012240 ! urethral meatus -relationship: inheres_in UBERON:0012240 ! urethral meatus +intersection_of: RO:0000052 UBERON:0012240 ! inheres in urethral meatus +relationship: RO:0000052 UBERON:0012240 ! inheres in urethral meatus [Term] id: OBA:0002005 @@ -116539,8 +215891,8 @@ synonym: "amount of external genitalia" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004176 ! external genitalia -relationship: inheres_in UBERON:0004176 ! external genitalia +intersection_of: RO:0000052 UBERON:0004176 ! inheres in external genitalia +relationship: RO:0000052 UBERON:0004176 ! inheres in external genitalia [Term] id: OBA:0002006 @@ -116550,7 +215902,7 @@ synonym: "concavity of scrotum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002669 ! scrotum morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001300 ! scrotum +intersection_of: RO:0000052 UBERON:0001300 ! inheres in scrotum [Term] id: OBA:0002007 @@ -116560,7 +215912,7 @@ synonym: "size of reproductive system" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002160 ! reproductive system morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000990 ! reproductive system +intersection_of: RO:0000052 UBERON:0000990 ! inheres in reproductive system [Term] id: OBA:0002008 @@ -116570,7 +215922,7 @@ synonym: "closure of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000537 ! urethra morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:0002009 @@ -116580,7 +215932,7 @@ synonym: "amount of renal collecting system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000587 ! renal collecting system quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004100 ! renal collecting system +intersection_of: RO:0000052 UBERON:0004100 ! inheres in renal collecting system [Term] id: OBA:0002010 @@ -116590,8 +215942,8 @@ synonym: "displaced of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0002011 @@ -116601,7 +215953,7 @@ synonym: "rate of micturition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000368 ! micturition quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060073 ! micturition +intersection_of: RO:0000052 GO:0060073 ! inheres in micturition [Term] id: OBA:0002012 @@ -116611,8 +215963,8 @@ synonym: "amount of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0002013 @@ -116622,7 +215974,7 @@ synonym: "composition of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002000 ! kidney structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0002014 @@ -116632,8 +215984,8 @@ synonym: "functionality of nephron tubule" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001231 ! nephron tubule -relationship: inheres_in UBERON:0001231 ! nephron tubule +intersection_of: RO:0000052 UBERON:0001231 ! inheres in nephron tubule +relationship: RO:0000052 UBERON:0001231 ! inheres in nephron tubule [Term] id: OBA:0002015 @@ -116643,7 +215995,7 @@ synonym: "size of renal pelvis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004194 ! kidney pelvis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001224 ! renal pelvis +intersection_of: RO:0000052 UBERON:0001224 ! inheres in renal pelvis [Term] id: OBA:0002016 @@ -116653,8 +216005,8 @@ synonym: "structure of gonad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000991 ! gonad -relationship: inheres_in UBERON:0000991 ! gonad +intersection_of: RO:0000052 UBERON:0000991 ! inheres in gonad +relationship: RO:0000052 UBERON:0000991 ! inheres in gonad [Term] id: OBA:0002017 @@ -116663,8 +216015,8 @@ def: "The size of a gonad." [AUTO:patterns/patterns/entity_attribute] synonym: "size of gonad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000991 ! gonad -relationship: inheres_in UBERON:0000991 ! gonad +intersection_of: RO:0000052 UBERON:0000991 ! inheres in gonad +relationship: RO:0000052 UBERON:0000991 ! inheres in gonad [Term] id: OBA:0002018 @@ -116674,7 +216026,7 @@ synonym: "concavity of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002146 ! uterus shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0002019 @@ -116684,8 +216036,8 @@ synonym: "position of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000995 ! uterus -relationship: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus +relationship: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0002020 @@ -116695,7 +216047,7 @@ synonym: "amount of menstruation" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000473 ! menstruation quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042703 ! menstruation +intersection_of: RO:0000052 GO:0042703 ! inheres in menstruation [Term] id: OBA:0002021 @@ -116705,7 +216057,7 @@ synonym: "structure of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002016 ! gonad structure is_a: OBA:VT0001126 ! ovary morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:0002022 @@ -116715,7 +216067,7 @@ synonym: "closure of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001139 ! vagina morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0002023 @@ -116725,8 +216077,8 @@ synonym: "amount of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000995 ! uterus -relationship: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus +relationship: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0002024 @@ -116736,7 +216088,7 @@ synonym: "size of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000452 ! mouth morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:0002025 @@ -116746,7 +216098,7 @@ synonym: "size of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000762 ! tongue morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0002026 @@ -116756,7 +216108,7 @@ synonym: "displaced of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003184 ! tongue position is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0002027 @@ -116766,7 +216118,7 @@ synonym: "closure of secondary palate" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0003755 ! palate morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:0002028 @@ -116776,8 +216128,8 @@ synonym: "closure of bony part of hard palate" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0012074 ! bony part of hard palate -relationship: inheres_in UBERON:0012074 ! bony part of hard palate +intersection_of: RO:0000052 UBERON:0012074 ! inheres in bony part of hard palate +relationship: RO:0000052 UBERON:0012074 ! inheres in bony part of hard palate [Term] id: OBA:0002029 @@ -116787,8 +216139,8 @@ synonym: "position of lower lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000474 ! lip quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001835 ! lower lip -relationship: inheres_in UBERON:0001835 ! lower lip +intersection_of: RO:0000052 UBERON:0001835 ! inheres in lower lip +relationship: RO:0000052 UBERON:0001835 ! inheres in lower lip [Term] id: OBA:0002030 @@ -116798,7 +216150,7 @@ synonym: "closure of soft palate" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0003154 ! soft palate morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001733 ! soft palate +intersection_of: RO:0000052 UBERON:0001733 ! inheres in soft palate [Term] id: OBA:0002031 @@ -116808,7 +216160,7 @@ synonym: "size of alveolar ridge" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004189 ! alveolar process morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004103 ! alveolar ridge +intersection_of: RO:0000052 UBERON:0004103 ! inheres in alveolar ridge [Term] id: OBA:0002032 @@ -116818,7 +216170,7 @@ synonym: "length of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002044 ! upper lip size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0002033 @@ -116828,7 +216180,7 @@ synonym: "size of secondary palate" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003755 ! palate morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:0002034 @@ -116838,8 +216190,8 @@ synonym: "concavity of palatine uvula" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001734 ! palatine uvula -relationship: inheres_in UBERON:0001734 ! palatine uvula +intersection_of: RO:0000052 UBERON:0001734 ! inheres in palatine uvula +relationship: RO:0000052 UBERON:0001734 ! inheres in palatine uvula [Term] id: OBA:0002035 @@ -116849,7 +216201,7 @@ synonym: "closure of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000452 ! mouth morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:0002036 @@ -116860,7 +216212,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005793 ! frenulum of tongue morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006689 ! frenulum of tongue +intersection_of: RO:0000052 UBERON:0006689 ! inheres in frenulum of tongue [Term] id: OBA:0002037 @@ -116870,7 +216222,7 @@ synonym: "closure of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005681 ! upper lip morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0002038 @@ -116880,7 +216232,7 @@ synonym: "2-D shape of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003749 ! mouth shape trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:0002039 @@ -116891,7 +216243,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000188 ! gingiva quality is_a: OBA:VT0003745 ! mouth mucosa morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001828 ! gingiva +intersection_of: RO:0000052 UBERON:0001828 ! inheres in gingiva [Term] id: OBA:0002040 @@ -116901,8 +216253,8 @@ synonym: "position of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000474 ! lip quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001834 ! upper lip -relationship: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip +relationship: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0002041 @@ -116912,7 +216264,7 @@ synonym: "size of alveolar process of maxilla" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002031 ! alveolar ridge size is_a: OBA:1000877 ! alveolar process of maxilla quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004527 ! alveolar process of maxilla +intersection_of: RO:0000052 UBERON:0004527 ! inheres in alveolar process of maxilla [Term] id: OBA:0002042 @@ -116922,8 +216274,8 @@ synonym: "wetness of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001822 ! wetness intersection_of: PATO:0001822 ! wetness -intersection_of: inheres_in UBERON:0000165 ! mouth -relationship: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth +relationship: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:0002043 @@ -116933,7 +216285,7 @@ synonym: "height of secondary palate" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002033 ! secondary palate size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:0002044 @@ -116943,7 +216295,7 @@ synonym: "size of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003868 ! lip size is_a: OBA:0005681 ! upper lip morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0002045 @@ -116953,7 +216305,7 @@ synonym: "texture of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000762 ! tongue morphology trait is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0002046 @@ -116963,7 +216315,7 @@ synonym: "spatial pattern of lower lip" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003867 ! lip spatial pattern is_a: OBA:0005682 ! lower lip morphology intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001835 ! lower lip +intersection_of: RO:0000052 UBERON:0001835 ! inheres in lower lip [Term] id: OBA:0002047 @@ -116972,18 +216324,18 @@ def: "The size of a anterior fontanel." [AUTO:patterns/patterns/entity_attribute synonym: "size of anterior fontanel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002048 ! fontanelle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002510 ! anterior fontanel -relationship: inheres_in UBERON:0002510 ! anterior fontanel +intersection_of: RO:0000052 UBERON:0002510 ! inheres in anterior fontanel +relationship: RO:0000052 UBERON:0002510 ! inheres in anterior fontanel [Term] id: OBA:0002048 name: fontanelle size def: "The size of a fontanelle." [AUTO:patterns/patterns/entity_attribute] synonym: "size of fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0000015 ! anatomical structure size +is_a: OBA:0003154 ! cranial suture size is_a: OBA:VT0000084 ! fontanelle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002221 ! fontanelle +intersection_of: RO:0000052 UBERON:0002221 ! inheres in fontanelle [Term] id: OBA:0002049 @@ -116993,7 +216345,7 @@ synonym: "position of tetrapod parietal bone" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000520 ! tetrapod parietal bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000210 ! tetrapod parietal bone +intersection_of: RO:0000052 UBERON:0000210 ! inheres in tetrapod parietal bone [Term] id: OBA:0002050 @@ -117003,7 +216355,7 @@ synonym: "2-D shape of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000432 ! head morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:0002051 @@ -117013,8 +216365,8 @@ synonym: "mass density of vault of skull" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004339 ! vault of skull -relationship: inheres_in UBERON:0004339 ! vault of skull +intersection_of: RO:0000052 UBERON:0004339 ! inheres in vault of skull +relationship: RO:0000052 UBERON:0004339 ! inheres in vault of skull [Term] id: OBA:0002052 @@ -117024,17 +216376,17 @@ synonym: "position of occipital bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000618 ! occipital bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:0002053 name: fontanelle onset quality def: "The onset quality of a fontanelle." [AUTO:patterns/patterns/entity_attribute] synonym: "onset quality of fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0003444 ! cranial suture onset quality is_a: OBA:1000350 ! fontanelle quality -is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0002221 ! fontanelle +intersection_of: RO:0000052 UBERON:0002221 ! inheres in fontanelle [Term] id: OBA:0002054 @@ -117044,7 +216396,7 @@ synonym: "size of jugal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0005270 ! zygomatic bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001683 ! jugal bone +intersection_of: RO:0000052 UBERON:0001683 ! inheres in jugal bone [Term] id: OBA:0002055 @@ -117054,7 +216406,7 @@ synonym: "size of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003743 ! facial morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002056 @@ -117064,7 +216416,7 @@ synonym: "length of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002055 ! face size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002057 @@ -117074,7 +216426,7 @@ synonym: "displaced of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002063 ! mandible position is_a: OBA:0004786 ! bone element displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0002058 @@ -117084,7 +216436,7 @@ synonym: "texture of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003743 ! facial morphology trait is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002059 @@ -117094,7 +216446,7 @@ synonym: "composition of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003743 ! facial morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002060 @@ -117105,7 +216457,7 @@ is_a: OBA:0003618 ! zone of skin size is_a: OBA:VT0006168 ! epicanthal fold morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0013766 ! epicanthal fold +intersection_of: RO:0000052 UBERON:0013766 ! inheres in epicanthal fold [Term] id: OBA:0002061 @@ -117115,7 +216467,7 @@ synonym: "size of philtrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005639 ! philtrum morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum [Term] id: OBA:0002062 @@ -117125,7 +216477,7 @@ synonym: "convex 3-D shape of face" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002280 ! face shape is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002063 @@ -117135,8 +216487,8 @@ synonym: "position of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position is_a: OBA:1000064 ! dermal bone quality intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001684 ! mandible -relationship: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible +relationship: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0002064 @@ -117146,7 +216498,7 @@ synonym: "sharpness of chin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003271 ! chin shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0008199 ! chin +intersection_of: RO:0000052 UBERON:0008199 ! inheres in chin [Term] id: OBA:0002065 @@ -117156,7 +216508,7 @@ synonym: "2-D shape of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002280 ! face shape is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002066 @@ -117166,7 +216518,7 @@ synonym: "curvature of philtrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005639 ! philtrum morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum [Term] id: OBA:0002067 @@ -117176,7 +216528,7 @@ synonym: "symmetry of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003743 ! facial morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002068 @@ -117186,7 +216538,7 @@ synonym: "size of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000455 ! maxilla morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002397 ! maxilla +intersection_of: RO:0000052 UBERON:0002397 ! inheres in maxilla [Term] id: OBA:0002069 @@ -117197,8 +216549,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008199 ! chin -relationship: inheres_in UBERON:0008199 ! chin +intersection_of: RO:0000052 UBERON:0008199 ! inheres in chin +relationship: RO:0000052 UBERON:0008199 ! inheres in chin [Term] id: OBA:0002070 @@ -117208,8 +216560,8 @@ synonym: "size of forehead" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008200 ! forehead -relationship: inheres_in UBERON:0008200 ! forehead +intersection_of: RO:0000052 UBERON:0008200 ! inheres in forehead +relationship: RO:0000052 UBERON:0008200 ! inheres in forehead [Term] id: OBA:0002071 @@ -117219,8 +216571,8 @@ synonym: "shape of forehead" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0008200 ! forehead -relationship: inheres_in UBERON:0008200 ! forehead +intersection_of: RO:0000052 UBERON:0008200 ! inheres in forehead +relationship: RO:0000052 UBERON:0008200 ! inheres in forehead [Term] id: OBA:0002072 @@ -117230,7 +216582,7 @@ synonym: "size of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003504 ! mandible morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0002073 @@ -117240,7 +216592,7 @@ synonym: "height of forehead" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002070 ! forehead size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0008200 ! forehead +intersection_of: RO:0000052 UBERON:0008200 ! inheres in forehead [Term] id: OBA:0002074 @@ -117250,8 +216602,8 @@ synonym: "position of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001690 ! ear -relationship: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear +relationship: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:0002075 @@ -117261,7 +216613,7 @@ synonym: "rotated of external ear" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003860 ! external ear spatial pattern is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0002076 @@ -117271,7 +216623,7 @@ synonym: "amount of sensory perception of sound" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000931 ! sensory perception of sound quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007605 ! sensory perception of sound +intersection_of: RO:0000052 GO:0007605 ! inheres in sensory perception of sound [Term] id: OBA:0002077 @@ -117281,8 +216633,8 @@ synonym: "position of external ear" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001691 ! external ear -relationship: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear +relationship: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0002078 @@ -117292,7 +216644,7 @@ synonym: "size of helix of outer ear" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000357 ! helix of outer ear quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002488 ! helix of outer ear +intersection_of: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear [Term] id: OBA:0002079 @@ -117302,8 +216654,8 @@ synonym: "position of antihelix" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0016466 ! antihelix -relationship: inheres_in UBERON:0016466 ! antihelix +intersection_of: RO:0000052 UBERON:0016466 ! inheres in antihelix +relationship: RO:0000052 UBERON:0016466 ! inheres in antihelix [Term] id: OBA:0002080 @@ -117313,7 +216665,7 @@ synonym: "size of external acoustic meatus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006033 ! external auditory canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001352 ! external acoustic meatus +intersection_of: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus [Term] id: OBA:0002081 @@ -117323,8 +216675,8 @@ synonym: "amount of vibrational conductance of sound to the inner ear" EXACT [AU is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0055127 ! vibrational conductance of sound to the inner ear -relationship: inheres_in GO:0055127 ! vibrational conductance of sound to the inner ear +intersection_of: RO:0000052 GO:0055127 ! inheres in vibrational conductance of sound to the inner ear +relationship: RO:0000052 GO:0055127 ! inheres in vibrational conductance of sound to the inner ear [Term] id: OBA:0002082 @@ -117334,7 +216686,7 @@ synonym: "closure of external acoustic meatus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0006033 ! external auditory canal morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001352 ! external acoustic meatus +intersection_of: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus [Term] id: OBA:0002083 @@ -117344,7 +216696,7 @@ synonym: "size of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002233 ! nose morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0002084 @@ -117354,7 +216706,7 @@ synonym: "shape of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002233 ! nose morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0002085 @@ -117364,7 +216716,7 @@ synonym: "length of nasal septum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002595 ! nasal septum size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001706 ! nasal septum +intersection_of: RO:0000052 UBERON:0001706 ! inheres in nasal septum [Term] id: OBA:0002086 @@ -117374,8 +216726,8 @@ synonym: "position of nasal bridge" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0008340 ! nasal bridge -relationship: inheres_in UBERON:0008340 ! nasal bridge +intersection_of: RO:0000052 UBERON:0008340 ! inheres in nasal bridge +relationship: RO:0000052 UBERON:0008340 ! inheres in nasal bridge [Term] id: OBA:0002087 @@ -117385,8 +216737,8 @@ synonym: "size of nasal cartilage" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002355 ! cartilage element morphology is_a: OBA:0003727 ! cartilage tissue size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001823 ! nasal cartilage -relationship: inheres_in UBERON:0001823 ! nasal cartilage +intersection_of: RO:0000052 UBERON:0001823 ! inheres in nasal cartilage +relationship: RO:0000052 UBERON:0001823 ! inheres in nasal cartilage [Term] id: OBA:0002088 @@ -117395,8 +216747,8 @@ def: "The size of a nasal bridge." [AUTO:patterns/patterns/entity_attribute] synonym: "size of nasal bridge" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008340 ! nasal bridge -relationship: inheres_in UBERON:0008340 ! nasal bridge +intersection_of: RO:0000052 UBERON:0008340 ! inheres in nasal bridge +relationship: RO:0000052 UBERON:0008340 ! inheres in nasal bridge [Term] id: OBA:0002089 @@ -117406,8 +216758,8 @@ synonym: "curvature of nose tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0012128 ! nose tip -relationship: inheres_in UBERON:0012128 ! nose tip +intersection_of: RO:0000052 UBERON:0012128 ! inheres in nose tip +relationship: RO:0000052 UBERON:0012128 ! inheres in nose tip [Term] id: OBA:0002090 @@ -117417,7 +216769,7 @@ synonym: "size of nasal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000102 ! nasal bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001681 ! nasal bone +intersection_of: RO:0000052 UBERON:0001681 ! inheres in nasal bone [Term] id: OBA:0002091 @@ -117427,8 +216779,8 @@ synonym: "position of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000004 ! nose -relationship: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose +relationship: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0002092 @@ -117438,8 +216790,8 @@ synonym: "2-D shape of nose tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0012128 ! nose tip -relationship: inheres_in UBERON:0012128 ! nose tip +intersection_of: RO:0000052 UBERON:0012128 ! inheres in nose tip +relationship: RO:0000052 UBERON:0012128 ! inheres in nose tip [Term] id: OBA:0002093 @@ -117449,8 +216801,8 @@ synonym: "structure of internal naris" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0010425 ! internal naris -relationship: inheres_in UBERON:0010425 ! internal naris +intersection_of: RO:0000052 UBERON:0010425 ! inheres in internal naris +relationship: RO:0000052 UBERON:0010425 ! inheres in internal naris [Term] id: OBA:0002094 @@ -117460,8 +216812,8 @@ synonym: "closure of internal naris" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0010425 ! internal naris -relationship: inheres_in UBERON:0010425 ! internal naris +intersection_of: RO:0000052 UBERON:0010425 ! inheres in internal naris +relationship: RO:0000052 UBERON:0010425 ! inheres in internal naris [Term] id: OBA:0002095 @@ -117471,7 +216823,7 @@ synonym: "curvature of external naris" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0002235 ! external nares morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0002096 @@ -117481,8 +216833,8 @@ synonym: "size of nose tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012128 ! nose tip -relationship: inheres_in UBERON:0012128 ! nose tip +intersection_of: RO:0000052 UBERON:0012128 ! inheres in nose tip +relationship: RO:0000052 UBERON:0012128 ! inheres in nose tip [Term] id: OBA:0002097 @@ -117492,8 +216844,8 @@ synonym: "concavity of nose tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0012128 ! nose tip -relationship: inheres_in UBERON:0012128 ! nose tip +intersection_of: RO:0000052 UBERON:0012128 ! inheres in nose tip +relationship: RO:0000052 UBERON:0012128 ! inheres in nose tip [Term] id: OBA:0002098 @@ -117503,7 +216855,7 @@ synonym: "curvature of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002084 ! nose shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0002099 @@ -117513,7 +216865,7 @@ synonym: "amount of sensory perception of smell" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0001984 ! olfaction trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007608 ! sensory perception of smell +intersection_of: RO:0000052 GO:0007608 ! inheres in sensory perception of smell [Term] id: OBA:0002100 @@ -117523,7 +216875,7 @@ synonym: "spatial pattern of external naris" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0002235 ! external nares morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0002101 @@ -117532,8 +216884,8 @@ def: "The strength of a muscle of neck." [AUTO:patterns/patterns/entity_attribut synonym: "strength of muscle of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0002377 ! muscle of neck -relationship: inheres_in UBERON:0002377 ! muscle of neck +intersection_of: RO:0000052 UBERON:0002377 ! inheres in muscle of neck +relationship: RO:0000052 UBERON:0002377 ! inheres in muscle of neck [Term] id: OBA:0002102 @@ -117543,7 +216895,7 @@ synonym: "length of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002103 ! neck size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000974 ! neck +intersection_of: RO:0000052 UBERON:0000974 ! inheres in neck [Term] id: OBA:0002103 @@ -117553,7 +216905,7 @@ synonym: "size of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005710 ! neck morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000974 ! neck +intersection_of: RO:0000052 UBERON:0000974 ! inheres in neck [Term] id: OBA:0002104 @@ -117563,7 +216915,7 @@ synonym: "size of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001312 ! cornea morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0002105 @@ -117573,8 +216925,8 @@ synonym: "alignment of anatomical line between pupils" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001652 ! alignment intersection_of: PATO:0001652 ! alignment -intersection_of: inheres_in UBERON:0010222 ! anatomical line between pupils -relationship: inheres_in UBERON:0010222 ! anatomical line between pupils +intersection_of: RO:0000052 UBERON:0010222 ! inheres in anatomical line between pupils +relationship: RO:0000052 UBERON:0010222 ! inheres in anatomical line between pupils [Term] id: OBA:0002106 @@ -117584,7 +216936,7 @@ synonym: "position of eyeball of camera-type eye" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000608 ! eyeball of camera-type eye quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:0002107 @@ -117594,8 +216946,8 @@ synonym: "shape of palpebral fissure" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001819 ! palpebral fissure -relationship: inheres_in UBERON:0001819 ! palpebral fissure +intersection_of: RO:0000052 UBERON:0001819 ! inheres in palpebral fissure +relationship: RO:0000052 UBERON:0001819 ! inheres in palpebral fissure [Term] id: OBA:0002108 @@ -117605,7 +216957,7 @@ synonym: "shape of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001340 ! eyelid morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0002109 @@ -117615,7 +216967,7 @@ synonym: "amount of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000385 ! iris quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris [Term] id: OBA:0002110 @@ -117625,7 +216977,7 @@ synonym: "length of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000417 ! hair length is_a: OBA:VT0004095 ! eyelash morphology trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0002111 @@ -117635,7 +216987,7 @@ synonym: "amount of eyeball of camera-type eye" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000608 ! eyeball of camera-type eye quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:0002112 @@ -117645,8 +216997,8 @@ synonym: "spatial pattern of eyebrow" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0010163 ! eyebrow -relationship: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow +relationship: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002113 @@ -117656,7 +217008,7 @@ synonym: "structure of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001312 ! cornea morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0002114 @@ -117665,8 +217017,8 @@ def: "The amount of a eyelash." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001702 ! eyelash -relationship: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash +relationship: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0002115 @@ -117676,7 +217028,7 @@ synonym: "closure of lacrimal drainage system" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002805 ! lacrimal drainage system morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001850 ! lacrimal drainage system +intersection_of: RO:0000052 UBERON:0001850 ! inheres in lacrimal drainage system [Term] id: OBA:0002116 @@ -117686,7 +217038,7 @@ synonym: "size of eyeball of camera-type eye" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0002129 ! eyeball of camera-type eye morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:0002117 @@ -117696,8 +217048,8 @@ synonym: "size of eyebrow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010163 ! eyebrow -relationship: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow +relationship: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002118 @@ -117706,8 +217058,8 @@ def: "The size of a palpebral fissure." [AUTO:patterns/patterns/entity_attribute synonym: "size of palpebral fissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001819 ! palpebral fissure -relationship: inheres_in UBERON:0001819 ! palpebral fissure +intersection_of: RO:0000052 UBERON:0001819 ! inheres in palpebral fissure +relationship: RO:0000052 UBERON:0001819 ! inheres in palpebral fissure [Term] id: OBA:0002119 @@ -117717,7 +217069,7 @@ synonym: "closure of eyeball of camera-type eye" EXACT [AUTO:patterns/patterns/e is_a: OBA:0002129 ! eyeball of camera-type eye morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:0002120 @@ -117727,7 +217079,7 @@ synonym: "size of sclera" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002698 ! sclera morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001773 ! sclera +intersection_of: RO:0000052 UBERON:0001773 ! inheres in sclera [Term] id: OBA:0002121 @@ -117737,8 +217089,8 @@ synonym: "movement behavioral quality of extra-ocular muscle" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0001601 ! extra-ocular muscle -relationship: inheres_in UBERON:0001601 ! extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle +relationship: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle [Term] id: OBA:0002122 @@ -117747,8 +217099,8 @@ def: "The texture of a periorbital skin." [AUTO:patterns/patterns/entity_attribu synonym: "texture of periorbital skin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003615 ! zone of skin texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0016462 ! periorbital skin -relationship: inheres_in UBERON:0016462 ! periorbital skin +intersection_of: RO:0000052 UBERON:0016462 ! inheres in periorbital skin +relationship: RO:0000052 UBERON:0016462 ! inheres in periorbital skin [Term] id: OBA:0002123 @@ -117758,7 +217110,7 @@ synonym: "size of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003638 ! cranial nerve II morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0002124 @@ -117768,8 +217120,8 @@ synonym: "photosensitivity of camera-type eye" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000927 ! photosensitivity intersection_of: PATO:0000927 ! photosensitivity -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0002125 @@ -117779,7 +217131,7 @@ synonym: "amount of visual perception" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0002090 ! vision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007601 ! visual perception +intersection_of: RO:0000052 GO:0007601 ! inheres in visual perception [Term] id: OBA:0002126 @@ -117789,7 +217141,7 @@ synonym: "spatial pattern of eyelash" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002806 ! strand of hair spatial pattern is_a: OBA:VT0004095 ! eyelash morphology trait intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0002127 @@ -117799,7 +217151,7 @@ synonym: "spatial pattern of eyelid" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0001340 ! eyelid morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0002128 @@ -117809,8 +217161,8 @@ synonym: "functionality of eyelid" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001711 ! eyelid -relationship: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid +relationship: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0002129 @@ -117820,7 +217172,7 @@ synonym: "morphology of eyeball of camera-type eye" EXACT [AUTO:patterns/pattern is_a: OBA:1000608 ! eyeball of camera-type eye quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:0002130 @@ -117830,8 +217182,8 @@ synonym: "amount of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth -relationship: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth +relationship: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:0002131 @@ -117840,8 +217192,8 @@ def: "The size of a upper central secondary incisor tooth." [AUTO:patterns/patte synonym: "size of upper central secondary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000113 ! incisor size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016454 ! upper central secondary incisor tooth -relationship: inheres_in UBERON:0016454 ! upper central secondary incisor tooth +intersection_of: RO:0000052 UBERON:0016454 ! inheres in upper central secondary incisor tooth +relationship: RO:0000052 UBERON:0016454 ! inheres in upper central secondary incisor tooth [Term] id: OBA:0002132 @@ -117851,8 +217203,8 @@ synonym: "position of dentition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0003672 ! dentition -relationship: inheres_in UBERON:0003672 ! dentition +intersection_of: RO:0000052 UBERON:0003672 ! inheres in dentition +relationship: RO:0000052 UBERON:0003672 ! inheres in dentition [Term] id: OBA:0002133 @@ -117862,7 +217214,7 @@ synonym: "color of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002576 ! enamel morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:0002134 @@ -117872,8 +217224,8 @@ synonym: "size of dentition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003672 ! dentition -relationship: inheres_in UBERON:0003672 ! dentition +intersection_of: RO:0000052 UBERON:0003672 ! inheres in dentition +relationship: RO:0000052 UBERON:0003672 ! inheres in dentition [Term] id: OBA:0002135 @@ -117883,8 +217235,8 @@ synonym: "amount of upper lateral incisor tooth" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003420 ! lateral incisor tooth amount is_a: OBA:0003424 ! upper jaw incisor amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018604 ! upper lateral incisor tooth -relationship: inheres_in UBERON:0018604 ! upper lateral incisor tooth +intersection_of: RO:0000052 UBERON:0018604 ! inheres in upper lateral incisor tooth +relationship: RO:0000052 UBERON:0018604 ! inheres in upper lateral incisor tooth [Term] id: OBA:0002136 @@ -117894,8 +217246,8 @@ synonym: "convex 3-D shape of dentition" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003672 ! dentition -relationship: inheres_in UBERON:0003672 ! dentition +intersection_of: RO:0000052 UBERON:0003672 ! inheres in dentition +relationship: RO:0000052 UBERON:0003672 ! inheres in dentition [Term] id: OBA:0002137 @@ -117905,7 +217257,7 @@ synonym: "structure of dentine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002818 ! dentin morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001751 ! dentine +intersection_of: RO:0000052 UBERON:0001751 ! inheres in dentine [Term] id: OBA:0002138 @@ -117915,7 +217267,7 @@ synonym: "structure of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002576 ! enamel morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:0002139 @@ -117925,8 +217277,8 @@ synonym: "damage of sensory nerve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002429 ! nerve structure is_a: PATO:0001020 ! damage intersection_of: PATO:0001020 ! damage -intersection_of: inheres_in UBERON:0001027 ! sensory nerve -relationship: inheres_in UBERON:0001027 ! sensory nerve +intersection_of: RO:0000052 UBERON:0001027 ! inheres in sensory nerve +relationship: RO:0000052 UBERON:0001027 ! inheres in sensory nerve [Term] id: OBA:0002140 @@ -117936,7 +217288,7 @@ synonym: "degeneration of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005404 ! axon morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon [Term] id: OBA:0002141 @@ -117946,7 +217298,7 @@ synonym: "concavity of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004320 ! sternum shape trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:0002142 @@ -117956,8 +217308,8 @@ synonym: "position of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000975 ! sternum -relationship: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum +relationship: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:0002143 @@ -117967,7 +217319,7 @@ synonym: "length of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002150 ! rib size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002144 @@ -117977,8 +217329,8 @@ synonym: "size of anterior chest" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016416 ! anterior chest -relationship: inheres_in UBERON:0016416 ! anterior chest +intersection_of: RO:0000052 UBERON:0016416 ! inheres in anterior chest +relationship: RO:0000052 UBERON:0016416 ! inheres in anterior chest [Term] id: OBA:0002145 @@ -117988,7 +217340,7 @@ synonym: "fertility of multicellular organism" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000274 ! fertility intersection_of: PATO:0000274 ! fertility -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0002146 @@ -117998,7 +217350,7 @@ synonym: "shape of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001120 ! uterus morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0002147 @@ -118008,7 +217360,7 @@ synonym: "onset quality of development of secondary sexual characteristics" EXAC is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:1000683 ! development of secondary sexual characteristics quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0045136 ! development of secondary sexual characteristics +intersection_of: RO:0000052 GO:0045136 ! inheres in development of secondary sexual characteristics [Term] id: OBA:0002148 @@ -118018,7 +217370,7 @@ synonym: "rate of growth hormone secretion" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0003506 ! growth hormone secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030252 ! growth hormone secretion +intersection_of: RO:0000052 GO:0030252 ! inheres in growth hormone secretion [Term] id: OBA:0002149 @@ -118028,8 +217380,8 @@ synonym: "behavioural activity of renin-angiotensin system" EXACT [AUTO:patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002265 ! behavioural activity intersection_of: PATO:0002265 ! behavioural activity -intersection_of: inheres_in UBERON:0018229 ! renin-angiotensin system -relationship: inheres_in UBERON:0018229 ! renin-angiotensin system +intersection_of: RO:0000052 UBERON:0018229 ! inheres in renin-angiotensin system +relationship: RO:0000052 UBERON:0018229 ! inheres in renin-angiotensin system [Term] id: OBA:0002150 @@ -118039,7 +217391,7 @@ synonym: "size of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000150 ! rib morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002151 @@ -118049,7 +217401,7 @@ synonym: "position of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000534 ! rib quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002152 @@ -118059,7 +217411,7 @@ synonym: "length of clavicle bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002381 ! long bone length is_a: OBA:VT0004338 ! clavicle size trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001105 ! clavicle bone +intersection_of: RO:0000052 UBERON:0001105 ! inheres in clavicle bone [Term] id: OBA:0002153 @@ -118069,7 +217421,7 @@ synonym: "concavity of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003157 ! rib shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002154 @@ -118079,7 +217431,7 @@ synonym: "position of costochondral joint" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000598 ! costochondral joint quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002293 ! costochondral joint +intersection_of: RO:0000052 UBERON:0002293 ! inheres in costochondral joint [Term] id: OBA:0002155 @@ -118089,7 +217441,7 @@ synonym: "curvature of thoracic rib cage" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0010092 ! thoracic cage morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003252 ! thoracic rib cage +intersection_of: RO:0000052 UBERON:0003252 ! inheres in thoracic rib cage [Term] id: OBA:0002156 @@ -118099,7 +217451,7 @@ synonym: "curvature of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003157 ! rib shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002157 @@ -118109,7 +217461,7 @@ synonym: "curvature of glenoid fossa" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000409 ! glenoid fossa quality is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0006657 ! glenoid fossa +intersection_of: RO:0000052 UBERON:0006657 ! inheres in glenoid fossa [Term] id: OBA:0002158 @@ -118120,7 +217472,7 @@ is_a: OBA:0002383 ! skeletal joint size is_a: OBA:1000598 ! costochondral joint quality is_a: OBA:1001080 ! joint of rib morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002293 ! costochondral joint +intersection_of: RO:0000052 UBERON:0002293 ! inheres in costochondral joint [Term] id: OBA:0002159 @@ -118130,7 +217482,7 @@ synonym: "amount of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000534 ! rib quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0002160 @@ -118139,8 +217491,8 @@ def: "The size of a compact bone of long bone." [AUTO:patterns/patterns/entity_a synonym: "size of compact bone of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002354 ! compact bone tissue size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016422 ! compact bone of long bone -relationship: inheres_in UBERON:0016422 ! compact bone of long bone +intersection_of: RO:0000052 UBERON:0016422 ! inheres in compact bone of long bone +relationship: RO:0000052 UBERON:0016422 ! inheres in compact bone of long bone [Term] id: OBA:0002161 @@ -118150,7 +217502,7 @@ synonym: "length of diaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002587 ! diaphysis size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004769 ! diaphysis +intersection_of: RO:0000052 UBERON:0004769 ! inheres in diaphysis [Term] id: OBA:0002162 @@ -118160,7 +217512,7 @@ synonym: "size of ilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002413 ! pelvic girdle bone/zone size is_a: OBA:VT0005354 ! ilium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001273 ! ilium +intersection_of: RO:0000052 UBERON:0001273 ! inheres in ilium [Term] id: OBA:0002163 @@ -118170,7 +217522,7 @@ synonym: "shape of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003723 ! long bone morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:0002164 @@ -118180,7 +217532,7 @@ synonym: "amount of palmar skin crease" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000347 ! palmar skin crease quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0019246 ! palmar skin crease +intersection_of: RO:0000052 UBERON:0019246 ! inheres in palmar skin crease [Term] id: OBA:0002165 @@ -118190,7 +217542,7 @@ synonym: "water composition of skin of body" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002174 ! skin of body structure is_a: PATO:0001800 ! water composition intersection_of: PATO:0001800 ! water composition -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002166 @@ -118200,7 +217552,7 @@ synonym: "color of skin of body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002167 @@ -118210,7 +217562,7 @@ synonym: "size of skin epidermis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001216 ! epidermis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001003 ! skin epidermis +intersection_of: RO:0000052 UBERON:0001003 ! inheres in skin epidermis [Term] id: OBA:0002168 @@ -118220,7 +217572,7 @@ synonym: "size of skin of body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000459 ! skin of body quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002169 @@ -118230,7 +217582,7 @@ synonym: "structure of ectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001050 ! ectoderm morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000924 ! ectoderm +intersection_of: RO:0000052 UBERON:0000924 ! inheres in ectoderm [Term] id: OBA:0002170 @@ -118240,7 +217592,7 @@ synonym: "spatial pattern of skin of body" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002171 @@ -118250,7 +217602,7 @@ synonym: "elasticity of skin of body" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000459 ! skin of body quality is_a: PATO:0001031 ! elasticity intersection_of: PATO:0001031 ! elasticity -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002172 @@ -118260,7 +217612,7 @@ synonym: "hardness of skin of body" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000048 ! hardness intersection_of: PATO:0000048 ! hardness -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002173 @@ -118270,7 +217622,7 @@ synonym: "color saturation of skin of body" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002174 @@ -118280,7 +217632,7 @@ synonym: "structure of skin of body" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002175 @@ -118290,7 +217642,7 @@ synonym: "photosensitivity of skin of body" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000927 ! photosensitivity intersection_of: PATO:0000927 ! photosensitivity -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002176 @@ -118300,7 +217652,7 @@ synonym: "altered number of of subcutaneous adipose tissue" EXACT [AUTO:patterns is_a: OBA:0002891 ! adipose tissue altered number of is_a: OBA:0005324 ! subcutaneous adipose tissue morphology intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue [Term] id: OBA:0002177 @@ -118310,7 +217662,7 @@ synonym: "composition of lymphatic part of lymphoid system" EXACT [AUTO:patterns is_a: OBA:VT0010071 ! lymphatic system morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0006558 ! lymphatic part of lymphoid system +intersection_of: RO:0000052 UBERON:0006558 ! inheres in lymphatic part of lymphoid system [Term] id: OBA:0002178 @@ -118320,8 +217672,8 @@ synonym: "position of superficial vein" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000292 ! vein quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0035550 ! superficial vein -relationship: inheres_in UBERON:0035550 ! superficial vein +intersection_of: RO:0000052 UBERON:0035550 ! inheres in superficial vein +relationship: RO:0000052 UBERON:0035550 ! inheres in superficial vein [Term] id: OBA:0002179 @@ -118331,7 +217683,7 @@ synonym: "fragility of skin of body" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002174 ! skin of body structure is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002180 @@ -118341,7 +217693,7 @@ synonym: "displaced of lens of camera-type eye" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0006245 ! lens orientation trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:0002181 @@ -118351,7 +217703,7 @@ synonym: "structure of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003638 ! cranial nerve II morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0002182 @@ -118361,7 +217713,7 @@ synonym: "size of ocular fundus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002864 ! ocular fundus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003951 ! ocular fundus +intersection_of: RO:0000052 UBERON:0003951 ! inheres in ocular fundus [Term] id: OBA:0002183 @@ -118370,8 +217722,8 @@ def: "The size of a macula lutea." [AUTO:patterns/patterns/entity_attribute] synonym: "size of macula lutea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000053 ! macula lutea -relationship: inheres_in UBERON:0000053 ! macula lutea +intersection_of: RO:0000052 UBERON:0000053 ! inheres in macula lutea +relationship: RO:0000052 UBERON:0000053 ! inheres in macula lutea [Term] id: OBA:0002184 @@ -118381,7 +217733,7 @@ synonym: "damage of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002181 ! cranial nerve II structure is_a: PATO:0001020 ! damage intersection_of: PATO:0001020 ! damage -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0002185 @@ -118391,7 +217743,7 @@ synonym: "structure of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0005246 ! orbit morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:0002186 @@ -118401,7 +217753,7 @@ synonym: "shape of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001139 ! vagina morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0002187 @@ -118411,7 +217763,7 @@ synonym: "size of palmar part of manus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000487 ! palmar part of manus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008878 ! palmar part of manus +intersection_of: RO:0000052 UBERON:0008878 ! inheres in palmar part of manus [Term] id: OBA:0002188 @@ -118421,8 +217773,8 @@ synonym: "size of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000572 ! autopod morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002398 ! manus -relationship: inheres_in UBERON:0002398 ! manus +intersection_of: RO:0000052 UBERON:0002398 ! inheres in manus +relationship: RO:0000052 UBERON:0002398 ! inheres in manus [Term] id: OBA:0002189 @@ -118432,7 +217784,7 @@ synonym: "sharpness of manual digit" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002196 ! manual digit shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002190 @@ -118442,7 +217794,7 @@ synonym: "length of umbilical cord" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0001725 ! umbilical cord morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002331 ! umbilical cord +intersection_of: RO:0000052 UBERON:0002331 ! inheres in umbilical cord [Term] id: OBA:0002191 @@ -118452,7 +217804,7 @@ synonym: "position of distal segment of manual digit" EXACT [AUTO:patterns/patte is_a: OBA:1000423 ! distal segment of manual digit quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0009552 ! distal segment of manual digit +intersection_of: RO:0000052 UBERON:0009552 ! inheres in distal segment of manual digit [Term] id: OBA:0002192 @@ -118462,7 +217814,7 @@ synonym: "shape of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002110 ! digit morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:0002193 @@ -118473,7 +217825,7 @@ is_a: OBA:0002196 ! manual digit shape is_a: OBA:0005188 ! manual digit 1 morphology is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0002194 @@ -118483,7 +217835,7 @@ synonym: "structure of carpal region" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000554 ! carpus morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004452 ! carpal region +intersection_of: RO:0000052 UBERON:0004452 ! inheres in carpal region [Term] id: OBA:0002195 @@ -118493,7 +217845,7 @@ synonym: "size of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002651 ! long bone size is_a: OBA:0003763 ! metacarpal bone morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002196 @@ -118502,8 +217854,8 @@ def: "The shape of a manual digit." [AUTO:patterns/patterns/entity_attribute] synonym: "shape of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002192 ! digit shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002389 ! manual digit -relationship: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit +relationship: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002197 @@ -118512,8 +217864,8 @@ def: "The size of a thenar eminence." [AUTO:patterns/patterns/entity_attribute] synonym: "size of thenar eminence" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0017716 ! thenar eminence -relationship: inheres_in UBERON:0017716 ! thenar eminence +intersection_of: RO:0000052 UBERON:0017716 ! inheres in thenar eminence +relationship: RO:0000052 UBERON:0017716 ! inheres in thenar eminence [Term] id: OBA:0002198 @@ -118523,8 +217875,8 @@ synonym: "occurrence of cognition" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0050890 ! cognition -relationship: inheres_in GO:0050890 ! cognition +intersection_of: RO:0000052 GO:0050890 ! inheres in cognition +relationship: RO:0000052 GO:0050890 ! inheres in cognition [Term] id: OBA:0002199 @@ -118534,8 +217886,8 @@ synonym: "onset quality of developmental process" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0032502 ! developmental process -relationship: inheres_in GO:0032502 ! developmental process +intersection_of: RO:0000052 GO:0032502 ! inheres in developmental process +relationship: RO:0000052 GO:0032502 ! inheres in developmental process [Term] id: OBA:0002200 @@ -118545,7 +217897,7 @@ synonym: "rate of reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001961 ! reflex trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060004 ! reflex +intersection_of: RO:0000052 GO:0060004 ! inheres in reflex [Term] id: OBA:0002201 @@ -118555,8 +217907,8 @@ synonym: "amount of corpus callosum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002336 ! corpus callosum -relationship: inheres_in UBERON:0002336 ! corpus callosum +intersection_of: RO:0000052 UBERON:0002336 ! inheres in corpus callosum +relationship: RO:0000052 UBERON:0002336 ! inheres in corpus callosum [Term] id: OBA:0002202 @@ -118566,7 +217918,7 @@ synonym: "amount of reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001961 ! reflex trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060004 ! reflex +intersection_of: RO:0000052 GO:0060004 ! inheres in reflex [Term] id: OBA:0002203 @@ -118576,7 +217928,7 @@ synonym: "morphology of posterior cranial fossa" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000273 ! posterior cranial fossa quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008788 ! posterior cranial fossa +intersection_of: RO:0000052 UBERON:0008788 ! inheres in posterior cranial fossa [Term] id: OBA:0002204 @@ -118586,8 +217938,8 @@ synonym: "amount of septum pellucidum" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004714 ! septum pellucidum -relationship: inheres_in UBERON:0004714 ! septum pellucidum +intersection_of: RO:0000052 UBERON:0004714 ! inheres in septum pellucidum +relationship: RO:0000052 UBERON:0004714 ! inheres in septum pellucidum [Term] id: OBA:0002205 @@ -118597,8 +217949,8 @@ synonym: "onset quality of skeletal joint" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0000982 ! skeletal joint -relationship: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint +relationship: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0002206 @@ -118609,7 +217961,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005503 ! tendon morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000043 ! tendon +intersection_of: RO:0000052 UBERON:0000043 ! inheres in tendon [Term] id: OBA:0002207 @@ -118619,8 +217971,8 @@ synonym: "displaced of skeletal joint" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000982 ! skeletal joint -relationship: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint +relationship: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0002208 @@ -118630,8 +217982,8 @@ synonym: "mobility of skeletal joint" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000004 ! mobility intersection_of: PATO:0000004 ! mobility -intersection_of: inheres_in UBERON:0000982 ! skeletal joint -relationship: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint +relationship: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0002209 @@ -118641,8 +217993,8 @@ synonym: "structure of hip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001464 ! hip -relationship: inheres_in UBERON:0001464 ! hip +intersection_of: RO:0000052 UBERON:0001464 ! inheres in hip +relationship: RO:0000052 UBERON:0001464 ! inheres in hip [Term] id: OBA:0002210 @@ -118652,7 +218004,7 @@ synonym: "composition of skeletal joint" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003754 ! skeletal joint morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0002211 @@ -118661,8 +218013,8 @@ def: "The size of a musculature of shoulder." [AUTO:patterns/patterns/entity_att synonym: "size of musculature of shoulder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004476 ! musculature of shoulder -relationship: inheres_in UBERON:0004476 ! musculature of shoulder +intersection_of: RO:0000052 UBERON:0004476 ! inheres in musculature of shoulder +relationship: RO:0000052 UBERON:0004476 ! inheres in musculature of shoulder [Term] id: OBA:0002212 @@ -118671,8 +218023,8 @@ def: "The onset quality of a anterior fontanel." [AUTO:patterns/patterns/entity_ synonym: "onset quality of anterior fontanel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002053 ! fontanelle onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0002510 ! anterior fontanel -relationship: inheres_in UBERON:0002510 ! anterior fontanel +intersection_of: RO:0000052 UBERON:0002510 ! inheres in anterior fontanel +relationship: RO:0000052 UBERON:0002510 ! inheres in anterior fontanel [Term] id: OBA:0002213 @@ -118682,7 +218034,7 @@ synonym: "size of carpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003518 ! carpal bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0002214 @@ -118692,8 +218044,8 @@ synonym: "size of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002110 ! digit morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002389 ! manual digit -relationship: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit +relationship: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002215 @@ -118703,7 +218055,7 @@ synonym: "rate of growth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0040007 ! growth +intersection_of: RO:0000052 GO:0040007 ! inheres in growth [Term] id: OBA:0002216 @@ -118713,7 +218065,7 @@ synonym: "onset quality of growth" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0100007 ! growth trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0040007 ! growth +intersection_of: RO:0000052 GO:0040007 ! inheres in growth [Term] id: OBA:0002217 @@ -118723,7 +218075,7 @@ synonym: "rate of embryo development" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005380 ! embryonic development trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0009790 ! embryo development +intersection_of: RO:0000052 GO:0009790 ! inheres in embryo development [Term] id: OBA:0002218 @@ -118733,7 +218085,7 @@ synonym: "position of abdomen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000625 ! abdomen quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000916 ! abdomen +intersection_of: RO:0000052 UBERON:0000916 ! inheres in abdomen [Term] id: OBA:0002219 @@ -118743,7 +218095,7 @@ synonym: "closure of abdominal wall" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0003257 ! abdominal wall morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003697 ! abdominal wall +intersection_of: RO:0000052 UBERON:0003697 ! inheres in abdominal wall [Term] id: OBA:0002220 @@ -118753,8 +218105,8 @@ synonym: "shape of rectus abdominis muscle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0005974 ! muscle of abdomen morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002382 ! rectus abdominis muscle -relationship: inheres_in UBERON:0002382 ! rectus abdominis muscle +intersection_of: RO:0000052 UBERON:0002382 ! inheres in rectus abdominis muscle +relationship: RO:0000052 UBERON:0002382 ! inheres in rectus abdominis muscle [Term] id: OBA:0002221 @@ -118764,8 +218116,8 @@ synonym: "position of umbilicus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0007118 ! umbilicus -relationship: inheres_in UBERON:0007118 ! umbilicus +intersection_of: RO:0000052 UBERON:0007118 ! inheres in umbilicus +relationship: RO:0000052 UBERON:0007118 ! inheres in umbilicus [Term] id: OBA:0002222 @@ -118775,8 +218127,8 @@ synonym: "displaced of anus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001245 ! anus -relationship: inheres_in UBERON:0001245 ! anus +intersection_of: RO:0000052 UBERON:0001245 ! inheres in anus +relationship: RO:0000052 UBERON:0001245 ! inheres in anus [Term] id: OBA:0002223 @@ -118786,7 +218138,7 @@ synonym: "circumference of anterior chest" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002144 ! anterior chest size is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0016416 ! anterior chest +intersection_of: RO:0000052 UBERON:0016416 ! inheres in anterior chest [Term] id: OBA:0002224 @@ -118796,7 +218148,7 @@ synonym: "symmetry of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003917 ! chest morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:0002225 @@ -118806,8 +218158,8 @@ synonym: "length of diastema between upper central incisors" EXACT [AUTO:pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0035116 ! diastema between upper central incisors -relationship: inheres_in UBERON:0035116 ! diastema between upper central incisors +intersection_of: RO:0000052 UBERON:0035116 ! inheres in diastema between upper central incisors +relationship: RO:0000052 UBERON:0035116 ! inheres in diastema between upper central incisors [Term] id: OBA:0002226 @@ -118816,8 +218168,8 @@ def: "The size of a lower jaw incisor." [AUTO:patterns/patterns/entity_attribute synonym: "size of lower jaw incisor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000113 ! incisor size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003451 ! lower jaw incisor -relationship: inheres_in UBERON:0003451 ! lower jaw incisor +intersection_of: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor +relationship: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor [Term] id: OBA:0002227 @@ -118827,7 +218179,7 @@ synonym: "structure of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002249 ! larynx morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:0002228 @@ -118837,8 +218189,8 @@ synonym: "strength of laryngeal vocal fold" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0003706 ! laryngeal vocal fold -relationship: inheres_in UBERON:0003706 ! laryngeal vocal fold +intersection_of: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold +relationship: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold [Term] id: OBA:0002229 @@ -118848,8 +218200,8 @@ synonym: "movement behavioral quality of laryngeal vocal fold" EXACT [AUTO:patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0003706 ! laryngeal vocal fold -relationship: inheres_in UBERON:0003706 ! laryngeal vocal fold +intersection_of: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold +relationship: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold [Term] id: OBA:0002230 @@ -118859,7 +218211,7 @@ synonym: "onset quality of parturition" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0002907 ! parturition trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007567 ! parturition +intersection_of: RO:0000052 GO:0007567 ! inheres in parturition [Term] id: OBA:0002231 @@ -118869,7 +218221,7 @@ synonym: "closure of interventricular septum" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0007082 ! ventricle septum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:0002232 @@ -118879,7 +218231,7 @@ synonym: "closure of interatrial septum" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0007081 ! atrium septum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002085 ! interatrial septum +intersection_of: RO:0000052 UBERON:0002085 ! inheres in interatrial septum [Term] id: OBA:0002233 @@ -118889,8 +218241,8 @@ synonym: "position of mitral valve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002135 ! mitral valve -relationship: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve +relationship: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0002234 @@ -118900,8 +218252,8 @@ synonym: "amount of heart contraction" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060047 ! heart contraction -relationship: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction +relationship: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:0002235 @@ -118911,7 +218263,7 @@ synonym: "structure of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000044 ! pulmonary valve morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0002236 @@ -118921,7 +218273,7 @@ synonym: "closure of ductus arteriosus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004197 ! artery closure is_a: OBA:0005095 ! ductus arteriosus morphology intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0005440 ! ductus arteriosus +intersection_of: RO:0000052 UBERON:0005440 ! inheres in ductus arteriosus [Term] id: OBA:0002237 @@ -118932,7 +218284,7 @@ is_a: OBA:VT0000040 ! aortic valve morphology trait is_a: OBA:VT0000285 ! heart valve morphology trait is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0002238 @@ -118942,7 +218294,7 @@ synonym: "structure of aortic valve" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000040 ! aortic valve morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0002239 @@ -118951,8 +218303,8 @@ def: "The sufficiency of a mitral valve." [AUTO:patterns/patterns/entity_attribu synonym: "sufficiency of mitral valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004175 ! atrioventricular valve sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0002135 ! mitral valve -relationship: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve +relationship: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0002240 @@ -118962,7 +218314,7 @@ synonym: "structure of interatrial septum" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0007081 ! atrium septum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002085 ! interatrial septum +intersection_of: RO:0000052 UBERON:0002085 ! inheres in interatrial septum [Term] id: OBA:0002241 @@ -118971,8 +218323,8 @@ def: "The sufficiency of a aortic valve." [AUTO:patterns/patterns/entity_attribu synonym: "sufficiency of aortic valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004176 ! semi-lunar valve sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0002137 ! aortic valve -relationship: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve +relationship: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0002242 @@ -118982,7 +218334,7 @@ synonym: "structure of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003463 ! blood vessel structure is_a: OBA:VT0000272 ! aorta morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:0002243 @@ -118992,8 +218344,8 @@ synonym: "position of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve -relationship: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve +relationship: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0002244 @@ -119003,7 +218355,7 @@ synonym: "composition of coronary artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002403 ! artery composition is_a: OBA:0002600 ! coronary artery structure intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001621 ! coronary artery +intersection_of: RO:0000052 UBERON:0001621 ! inheres in coronary artery [Term] id: OBA:0002245 @@ -119013,7 +218365,7 @@ synonym: "structure of mitral valve" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000033 ! mitral valve morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0002246 @@ -119023,7 +218375,7 @@ synonym: "sufficiency of exocrine pancreas" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003288 ! exocrine pancreas functionality is_a: PATO:0001626 ! sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0000017 ! exocrine pancreas +intersection_of: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas [Term] id: OBA:0002247 @@ -119033,8 +218385,8 @@ synonym: "amount of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:0002248 @@ -119044,7 +218396,7 @@ synonym: "shape of cardiac ventricle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005294 ! heart ventricle morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002082 ! cardiac ventricle +intersection_of: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle [Term] id: OBA:0002249 @@ -119054,8 +218406,8 @@ synonym: "curvature of longitudinal arch of pes" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0035133 ! longitudinal arch of pes -relationship: inheres_in UBERON:0035133 ! longitudinal arch of pes +intersection_of: RO:0000052 UBERON:0035133 ! inheres in longitudinal arch of pes +relationship: RO:0000052 UBERON:0035133 ! inheres in longitudinal arch of pes [Term] id: OBA:0002250 @@ -119065,8 +218417,8 @@ synonym: "length of skeleton of pes" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001445 ! skeleton of pes -relationship: inheres_in UBERON:0001445 ! skeleton of pes +intersection_of: RO:0000052 UBERON:0001445 ! inheres in skeleton of pes +relationship: RO:0000052 UBERON:0001445 ! inheres in skeleton of pes [Term] id: OBA:0002251 @@ -119076,7 +218428,7 @@ synonym: "size of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002651 ! long bone size is_a: OBA:VT0003072 ! metatarsus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001448 ! metatarsal bone +intersection_of: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone [Term] id: OBA:0002252 @@ -119086,7 +218438,7 @@ synonym: "structure of tarsal region" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005104 ! tarsus morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004454 ! tarsal region +intersection_of: RO:0000052 UBERON:0004454 ! inheres in tarsal region [Term] id: OBA:0002253 @@ -119096,7 +218448,7 @@ synonym: "composition of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004147 ! multicellular organism composition is_a: OBA:1001076 ! embryo morphology intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:0002254 @@ -119106,7 +218458,7 @@ synonym: "size of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000579 ! nail morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:0002255 @@ -119115,8 +218467,8 @@ def: "The size of a nail of pedal digit." [AUTO:patterns/patterns/entity_attribu synonym: "size of nail of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002254 ! nail size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009567 ! nail of pedal digit -relationship: inheres_in UBERON:0009567 ! nail of pedal digit +intersection_of: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit +relationship: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit [Term] id: OBA:0002256 @@ -119126,8 +218478,8 @@ synonym: "amount of nail of pedal digit" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009567 ! nail of pedal digit -relationship: inheres_in UBERON:0009567 ! nail of pedal digit +intersection_of: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit +relationship: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit [Term] id: OBA:0002257 @@ -119136,8 +218488,8 @@ def: "The size of a nail of manual digit." [AUTO:patterns/patterns/entity_attrib synonym: "size of nail of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002254 ! nail size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009565 ! nail of manual digit -relationship: inheres_in UBERON:0009565 ! nail of manual digit +intersection_of: RO:0000052 UBERON:0009565 ! inheres in nail of manual digit +relationship: RO:0000052 UBERON:0009565 ! inheres in nail of manual digit [Term] id: OBA:0002258 @@ -119147,7 +218499,7 @@ synonym: "fragility of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002297 ! nail structure is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:0002259 @@ -119157,8 +218509,8 @@ synonym: "amount of nail of manual digit" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009565 ! nail of manual digit -relationship: inheres_in UBERON:0009565 ! nail of manual digit +intersection_of: RO:0000052 UBERON:0009565 ! inheres in nail of manual digit +relationship: RO:0000052 UBERON:0009565 ! inheres in nail of manual digit [Term] id: OBA:0002260 @@ -119168,7 +218520,7 @@ synonym: "deviation of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002268 ! pedal digit deviation is_a: OBA:0004592 ! pedal digit 1 morphology intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0002261 @@ -119178,7 +218530,7 @@ synonym: "length of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:VT0002544 ! digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0002262 @@ -119189,7 +218541,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000314 ! pedal digit quality is_a: OBA:VT0002110 ! digit morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0002263 @@ -119199,7 +218551,7 @@ synonym: "spatial pattern of talus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0005109 ! talus morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002395 ! talus +intersection_of: RO:0000052 UBERON:0002395 ! inheres in talus [Term] id: OBA:0002264 @@ -119209,7 +218561,7 @@ synonym: "length of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002261 ! pedal digit length is_a: OBA:0003048 ! pedal digit 1 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0002265 @@ -119218,8 +218570,8 @@ def: "The morphology of a calcaneus." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of calcaneus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002810 ! tarsal bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001450 ! calcaneus -relationship: inheres_in UBERON:0001450 ! calcaneus +intersection_of: RO:0000052 UBERON:0001450 ! inheres in calcaneus +relationship: RO:0000052 UBERON:0001450 ! inheres in calcaneus [Term] id: OBA:0002266 @@ -119232,7 +218584,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010105 ! hindlimb long bone morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0002267 @@ -119242,7 +218594,7 @@ synonym: "length of distal phalanx of pes" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002588 ! phalanx of pes length is_a: OBA:0003079 ! distal phalanx of pes size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0002268 @@ -119252,7 +218604,7 @@ synonym: "deviation of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003339 ! digit deviation is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0002269 @@ -119262,7 +218614,7 @@ synonym: "deviation of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002268 ! pedal digit deviation is_a: OBA:1000297 ! pedal digit 5 quality intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003635 ! pedal digit 5 +intersection_of: RO:0000052 UBERON:0003635 ! inheres in pedal digit 5 [Term] id: OBA:0002270 @@ -119272,8 +218624,8 @@ synonym: "shape of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000572 ! autopod morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002387 ! pes -relationship: inheres_in UBERON:0002387 ! pes +intersection_of: RO:0000052 UBERON:0002387 ! inheres in pes +relationship: RO:0000052 UBERON:0002387 ! inheres in pes [Term] id: OBA:0002271 @@ -119283,7 +218635,7 @@ synonym: "length of pedal digit 2" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002261 ! pedal digit length is_a: OBA:0003358 ! pedal digit 2 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003632 ! pedal digit 2 +intersection_of: RO:0000052 UBERON:0003632 ! inheres in pedal digit 2 [Term] id: OBA:0002272 @@ -119292,8 +218644,8 @@ def: "The amount of a reticulocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of reticulocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005899 ! myeloid cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000558 ! reticulocyte -relationship: inheres_in CL:0000558 ! reticulocyte +intersection_of: RO:0000052 CL:0000558 ! inheres in reticulocyte +relationship: RO:0000052 CL:0000558 ! inheres in reticulocyte [Term] id: OBA:0002273 @@ -119302,8 +218654,8 @@ def: "The mass of a erythroid lineage cell." [AUTO:patterns/patterns/entity_attr synonym: "mass of erythroid lineage cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000036 ! cell mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in CL:0000764 ! erythroid lineage cell -relationship: inheres_in CL:0000764 ! erythroid lineage cell +intersection_of: RO:0000052 CL:0000764 ! inheres in erythroid lineage cell +relationship: RO:0000052 CL:0000764 ! inheres in erythroid lineage cell [Term] id: OBA:0002274 @@ -119313,7 +218665,7 @@ synonym: "structure of renal artery" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003389 ! artery structure is_a: OBA:VT0010641 ! renal artery morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001184 ! renal artery +intersection_of: RO:0000052 UBERON:0001184 ! inheres in renal artery [Term] id: OBA:0002275 @@ -119323,7 +218675,7 @@ synonym: "structure of lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002619 ! lymphocyte morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in CL:0000542 ! lymphocyte +intersection_of: RO:0000052 CL:0000542 ! inheres in lymphocyte [Term] id: OBA:0002276 @@ -119333,8 +218685,8 @@ synonym: "rate of ketone body biosynthetic process" EXACT [AUTO:patterns/pattern is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0046951 ! ketone body biosynthetic process -relationship: inheres_in GO:0046951 ! ketone body biosynthetic process +intersection_of: RO:0000052 GO:0046951 ! inheres in ketone body biosynthetic process +relationship: RO:0000052 GO:0046951 ! inheres in ketone body biosynthetic process [Term] id: OBA:0002277 @@ -119344,8 +218696,8 @@ synonym: "occurrence of fever generation" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000356 ! temperature homeostasis quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0001660 ! fever generation -relationship: inheres_in GO:0001660 ! fever generation +intersection_of: RO:0000052 GO:0001660 ! inheres in fever generation +relationship: RO:0000052 GO:0001660 ! inheres in fever generation [Term] id: OBA:0002278 @@ -119355,7 +218707,7 @@ synonym: "displaced of hemopoiesis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0000240 ! hematopoiesis location trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in GO:0030097 ! hemopoiesis +intersection_of: RO:0000052 GO:0030097 ! inheres in hemopoiesis [Term] id: OBA:0002279 @@ -119366,8 +218718,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015066 ! surface structure morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008341 ! columella nasi -relationship: inheres_in UBERON:0008341 ! columella nasi +intersection_of: RO:0000052 UBERON:0008341 ! inheres in columella nasi +relationship: RO:0000052 UBERON:0008341 ! inheres in columella nasi [Term] id: OBA:0002280 @@ -119377,7 +218729,7 @@ synonym: "shape of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003743 ! facial morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0002281 @@ -119387,8 +218739,8 @@ synonym: "position of forehead" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0008200 ! forehead -relationship: inheres_in UBERON:0008200 ! forehead +intersection_of: RO:0000052 UBERON:0008200 ! inheres in forehead +relationship: RO:0000052 UBERON:0008200 ! inheres in forehead [Term] id: OBA:0002282 @@ -119398,8 +218750,8 @@ synonym: "quality of a liquid of feces" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001548 ! quality of a liquid intersection_of: PATO:0001548 ! quality of a liquid -intersection_of: inheres_in UBERON:0001988 ! feces -relationship: inheres_in UBERON:0001988 ! feces +intersection_of: RO:0000052 UBERON:0001988 ! inheres in feces +relationship: RO:0000052 UBERON:0001988 ! inheres in feces [Term] id: OBA:0002283 @@ -119409,7 +218761,7 @@ synonym: "frequency of defecation" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003877 ! defecation rate is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0030421 ! defecation +intersection_of: RO:0000052 GO:0030421 ! inheres in defecation [Term] id: OBA:0002284 @@ -119419,7 +218771,7 @@ synonym: "structure of pyloric antrum" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0005201 ! pyloric antrum morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001165 ! pyloric antrum +intersection_of: RO:0000052 UBERON:0001165 ! inheres in pyloric antrum [Term] id: OBA:0002285 @@ -119429,7 +218781,7 @@ synonym: "closure of anus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005034 ! anus morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001245 ! anus +intersection_of: RO:0000052 UBERON:0001245 ! inheres in anus [Term] id: OBA:0002286 @@ -119439,7 +218791,7 @@ synonym: "structure of anal canal" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0004595 ! anal canal morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000159 ! anal canal +intersection_of: RO:0000052 UBERON:0000159 ! inheres in anal canal [Term] id: OBA:0002287 @@ -119449,7 +218801,7 @@ synonym: "closure of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000467 ! esophagus morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:0002288 @@ -119459,8 +218811,8 @@ synonym: "position of rectum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001052 ! rectum -relationship: inheres_in UBERON:0001052 ! rectum +intersection_of: RO:0000052 UBERON:0001052 ! inheres in rectum +relationship: RO:0000052 UBERON:0001052 ! inheres in rectum [Term] id: OBA:0002289 @@ -119470,7 +218822,7 @@ synonym: "structure of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000467 ! esophagus morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:0002290 @@ -119480,7 +218832,7 @@ synonym: "size of cortex of kidney" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000521 ! kidney cortex morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001225 ! cortex of kidney +intersection_of: RO:0000052 UBERON:0001225 ! inheres in cortex of kidney [Term] id: OBA:0002291 @@ -119490,7 +218842,7 @@ synonym: "position of glabella region of bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000562 ! glabella region of bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0016440 ! glabella region of bone +intersection_of: RO:0000052 UBERON:0016440 ! inheres in glabella region of bone [Term] id: OBA:0002292 @@ -119500,7 +218852,7 @@ synonym: "size of telencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015105 ! cerebrum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001893 ! telencephalon +intersection_of: RO:0000052 UBERON:0001893 ! inheres in telencephalon [Term] id: OBA:0002293 @@ -119510,7 +218862,7 @@ synonym: "amount of respiratory gaseous exchange by respiratory system" EXACT [A is_a: OBA:1000805 ! respiratory gaseous exchange by respiratory system quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007585 ! respiratory gaseous exchange by respiratory system +intersection_of: RO:0000052 GO:0007585 ! inheres in respiratory gaseous exchange by respiratory system [Term] id: OBA:0002294 @@ -119520,7 +218872,7 @@ synonym: "size of brain ventricle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000822 ! brain ventricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004086 ! brain ventricle +intersection_of: RO:0000052 UBERON:0004086 ! inheres in brain ventricle [Term] id: OBA:0002295 @@ -119530,7 +218882,7 @@ synonym: "size of cerebral cortex" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000788 ! cerebral cortex morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000956 ! cerebral cortex +intersection_of: RO:0000052 UBERON:0000956 ! inheres in cerebral cortex [Term] id: OBA:0002296 @@ -119540,7 +218892,7 @@ synonym: "composition of basal ganglion" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0002751 ! basal ganglion structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002420 ! basal ganglion +intersection_of: RO:0000052 UBERON:0002420 ! inheres in basal ganglion [Term] id: OBA:0002297 @@ -119550,7 +218902,7 @@ synonym: "structure of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000579 ! nail morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:0002298 @@ -119560,7 +218912,7 @@ synonym: "composition of telencephalon" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0015105 ! cerebrum morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001893 ! telencephalon +intersection_of: RO:0000052 UBERON:0001893 ! inheres in telencephalon [Term] id: OBA:0002299 @@ -119570,7 +218922,7 @@ synonym: "onset quality of central nervous system myelination" EXACT [AUTO:patte is_a: OBA:0003308 ! myelination onset quality is_a: OBA:1000324 ! central nervous system myelination quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0022010 ! central nervous system myelination +intersection_of: RO:0000052 GO:0022010 ! inheres in central nervous system myelination [Term] id: OBA:0002300 @@ -119580,7 +218932,7 @@ synonym: "structure of cerebellar vermis" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000864 ! cerebellum vermis morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004720 ! cerebellar vermis +intersection_of: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis [Term] id: OBA:0002301 @@ -119590,7 +218942,7 @@ synonym: "composition of pleural cavity" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005706 ! pleural cavity morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002402 ! pleural cavity +intersection_of: RO:0000052 UBERON:0002402 ! inheres in pleural cavity [Term] id: OBA:0002302 @@ -119600,7 +218952,7 @@ synonym: "spatial pattern of hair of head" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002806 ! strand of hair spatial pattern is_a: OBA:1000405 ! hair of head quality intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0016446 ! hair of head +intersection_of: RO:0000052 UBERON:0016446 ! inheres in hair of head [Term] id: OBA:0002303 @@ -119610,7 +218962,7 @@ synonym: "spatial pattern of strand of axillary hair" EXACT [AUTO:patterns/patte is_a: OBA:0002806 ! strand of hair spatial pattern is_a: OBA:1000549 ! strand of axillary hair quality intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0013699 ! strand of axillary hair +intersection_of: RO:0000052 UBERON:0013699 ! inheres in strand of axillary hair [Term] id: OBA:0002304 @@ -119620,7 +218972,7 @@ synonym: "amount of strand of axillary hair" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000549 ! strand of axillary hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0013699 ! strand of axillary hair +intersection_of: RO:0000052 UBERON:0013699 ! inheres in strand of axillary hair [Term] id: OBA:0002305 @@ -119630,8 +218982,8 @@ synonym: "amount of eyebrow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010163 ! eyebrow -relationship: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow +relationship: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002306 @@ -119641,7 +218993,7 @@ synonym: "spatial pattern of strand of pubic hair" EXACT [AUTO:patterns/patterns is_a: OBA:0002806 ! strand of hair spatial pattern is_a: OBA:1000239 ! strand of pubic hair quality intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0013698 ! strand of pubic hair +intersection_of: RO:0000052 UBERON:0013698 ! inheres in strand of pubic hair [Term] id: OBA:0002307 @@ -119651,8 +219003,8 @@ synonym: "color of eyebrow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0010163 ! eyebrow -relationship: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow +relationship: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002308 @@ -119662,7 +219014,7 @@ synonym: "color of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002313 ! strand of hair color is_a: OBA:VT0004095 ! eyelash morphology trait intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0002309 @@ -119672,7 +219024,7 @@ synonym: "closure of duodenum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003271 ! duodenum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002114 ! duodenum +intersection_of: RO:0000052 UBERON:0002114 ! inheres in duodenum [Term] id: OBA:0002310 @@ -119682,8 +219034,8 @@ synonym: "amount of startle response" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001964 ! startle response -relationship: inheres_in GO:0001964 ! startle response +intersection_of: RO:0000052 GO:0001964 ! inheres in startle response +relationship: RO:0000052 GO:0001964 ! inheres in startle response [Term] id: OBA:0002311 @@ -119693,8 +219045,8 @@ synonym: "displaced of neural cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000076 ! attribute of cell is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0002319 ! neural cell -relationship: inheres_in CL:0002319 ! neural cell +intersection_of: RO:0000052 CL:0002319 ! inheres in neural cell +relationship: RO:0000052 CL:0002319 ! inheres in neural cell [Term] id: OBA:0002312 @@ -119704,7 +219056,7 @@ synonym: "color brightness of strand of hair" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0000016 ! color brightness intersection_of: PATO:0000016 ! color brightness -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0002313 @@ -119714,7 +219066,7 @@ synonym: "color of strand of hair" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0002314 @@ -119724,7 +219076,7 @@ synonym: "degeneration of lateral corticospinal tract" EXACT [AUTO:patterns/patt is_a: OBA:0004815 ! lateral corticospinal tract morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002589 ! lateral corticospinal tract +intersection_of: RO:0000052 UBERON:0002589 ! inheres in lateral corticospinal tract [Term] id: OBA:0002315 @@ -119734,8 +219086,8 @@ synonym: "amount of cerebellar vermis" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004720 ! cerebellar vermis -relationship: inheres_in UBERON:0004720 ! cerebellar vermis +intersection_of: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis +relationship: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis [Term] id: OBA:0002316 @@ -119745,7 +219097,7 @@ synonym: "size of caudate nucleus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0004078 ! caudate nucleus morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001873 ! caudate nucleus +intersection_of: RO:0000052 UBERON:0001873 ! inheres in caudate nucleus [Term] id: OBA:0002317 @@ -119755,7 +219107,7 @@ synonym: "structure of cerebellum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000849 ! cerebellum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002037 ! cerebellum +intersection_of: RO:0000052 UBERON:0002037 ! inheres in cerebellum [Term] id: OBA:0002318 @@ -119765,7 +219117,7 @@ synonym: "degeneration of cerebral hemisphere white matter" EXACT [AUTO:patterns is_a: OBA:0002771 ! cerebral hemisphere white matter structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002437 ! cerebral hemisphere white matter +intersection_of: RO:0000052 UBERON:0002437 ! inheres in cerebral hemisphere white matter [Term] id: OBA:0002319 @@ -119775,7 +219127,7 @@ synonym: "size of brainstem" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005277 ! brainstem morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002298 ! brainstem +intersection_of: RO:0000052 UBERON:0002298 ! inheres in brainstem [Term] id: OBA:0002320 @@ -119785,8 +219137,8 @@ synonym: "amount of musculoskeletal movement" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000727 ! multicellular organismal movement quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0050881 ! musculoskeletal movement -relationship: inheres_in GO:0050881 ! musculoskeletal movement +intersection_of: RO:0000052 GO:0050881 ! inheres in musculoskeletal movement +relationship: RO:0000052 GO:0050881 ! inheres in musculoskeletal movement [Term] id: OBA:0002321 @@ -119796,8 +219148,8 @@ synonym: "rate of musculoskeletal movement" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000727 ! multicellular organismal movement quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0050881 ! musculoskeletal movement -relationship: inheres_in GO:0050881 ! musculoskeletal movement +intersection_of: RO:0000052 GO:0050881 ! inheres in musculoskeletal movement +relationship: RO:0000052 GO:0050881 ! inheres in musculoskeletal movement [Term] id: OBA:0002322 @@ -119807,7 +219159,7 @@ synonym: "degeneration of motor neuron" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0000937 ! motor neuron morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000100 ! motor neuron +intersection_of: RO:0000052 CL:0000100 ! inheres in motor neuron [Term] id: OBA:0002323 @@ -119817,7 +219169,7 @@ synonym: "size of superior cerebellar peduncle of pons" EXACT [AUTO:patterns/pat is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000408 ! superior cerebellar peduncle of pons quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007709 ! superior cerebellar peduncle of pons +intersection_of: RO:0000052 UBERON:0007709 ! inheres in superior cerebellar peduncle of pons [Term] id: OBA:0002324 @@ -119827,7 +219179,7 @@ synonym: "structure of midbrain cerebral aqueduct" EXACT [AUTO:patterns/patterns is_a: OBA:0005705 ! brain ventricle structure is_a: OBA:VT0005537 ! cerebral aqueduct morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002289 ! midbrain cerebral aqueduct +intersection_of: RO:0000052 UBERON:0002289 ! inheres in midbrain cerebral aqueduct [Term] id: OBA:0002325 @@ -119837,7 +219189,7 @@ synonym: "composition of dentate nucleus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004942 ! dentate nucleus morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002132 ! dentate nucleus +intersection_of: RO:0000052 UBERON:0002132 ! inheres in dentate nucleus [Term] id: OBA:0002326 @@ -119847,8 +219199,8 @@ synonym: "amount of kinesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042465 ! kinesis -relationship: inheres_in GO:0042465 ! kinesis +intersection_of: RO:0000052 GO:0042465 ! inheres in kinesis +relationship: RO:0000052 GO:0042465 ! inheres in kinesis [Term] id: OBA:0002327 @@ -119858,7 +219210,7 @@ synonym: "functionality of corticospinal tract" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000490 ! corticospinal tract quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002707 ! corticospinal tract +intersection_of: RO:0000052 UBERON:0002707 ! inheres in corticospinal tract [Term] id: OBA:0002328 @@ -119868,7 +219220,7 @@ synonym: "degeneration of Ammon's horn" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000815 ! Ammon gyrus morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001954 ! Ammon's horn +intersection_of: RO:0000052 UBERON:0001954 ! inheres in Ammon's horn [Term] id: OBA:0002329 @@ -119878,7 +219230,7 @@ synonym: "structure of cerebral cortex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000788 ! cerebral cortex morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000956 ! cerebral cortex +intersection_of: RO:0000052 UBERON:0000956 ! inheres in cerebral cortex [Term] id: OBA:0002330 @@ -119888,8 +219240,8 @@ synonym: "amount of strand of hair of face" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000405 ! hair of head quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010171 ! strand of hair of face -relationship: inheres_in UBERON:0010171 ! strand of hair of face +intersection_of: RO:0000052 UBERON:0010171 ! inheres in strand of hair of face +relationship: RO:0000052 UBERON:0010171 ! inheres in strand of hair of face [Term] id: OBA:0002331 @@ -119899,7 +219251,7 @@ synonym: "structure of strand of hair" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0002332 @@ -119909,8 +219261,8 @@ synonym: "concavity of eyebrow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0010163 ! eyebrow -relationship: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow +relationship: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002333 @@ -119920,7 +219272,7 @@ synonym: "amount of strand of pubic hair" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000239 ! strand of pubic hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0013698 ! strand of pubic hair +intersection_of: RO:0000052 UBERON:0013698 ! inheres in strand of pubic hair [Term] id: OBA:0002334 @@ -119930,7 +219282,7 @@ synonym: "size of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006078 ! nipple morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:0002335 @@ -119940,8 +219292,8 @@ synonym: "amount of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002030 ! nipple -relationship: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple +relationship: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:0002336 @@ -119951,8 +219303,8 @@ synonym: "position of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002030 ! nipple -relationship: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple +relationship: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:0002337 @@ -119962,7 +219314,7 @@ synonym: "rotated of alimentary part of gastrointestinal system" EXACT [AUTO:pat is_a: OBA:0003324 ! alimentary part of gastrointestinal system morphology is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0002338 @@ -119972,8 +219324,8 @@ synonym: "strength of stomach muscularis externa" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0008856 ! stomach muscularis externa -relationship: inheres_in UBERON:0008856 ! stomach muscularis externa +intersection_of: RO:0000052 UBERON:0008856 ! inheres in stomach muscularis externa +relationship: RO:0000052 UBERON:0008856 ! inheres in stomach muscularis externa [Term] id: OBA:0002339 @@ -119983,7 +219335,7 @@ synonym: "contractility of alimentary part of gastrointestinal system" EXACT [AU is_a: OBA:1000149 ! alimentary part of gastrointestinal system quality is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0002340 @@ -119993,7 +219345,7 @@ synonym: "closure of alimentary part of gastrointestinal system" EXACT [AUTO:pat is_a: OBA:0003324 ! alimentary part of gastrointestinal system morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0002341 @@ -120003,8 +219355,8 @@ synonym: "size of abdominal aorta artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000032 ! blood vessel size is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012254 ! abdominal aorta artery -relationship: inheres_in UBERON:0012254 ! abdominal aorta artery +intersection_of: RO:0000052 UBERON:0012254 ! inheres in abdominal aorta artery +relationship: RO:0000052 UBERON:0012254 ! inheres in abdominal aorta artery [Term] id: OBA:0002342 @@ -120014,8 +219366,8 @@ synonym: "structure of skeleton" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004288 ! skeleton -relationship: inheres_in UBERON:0004288 ! skeleton +intersection_of: RO:0000052 UBERON:0004288 ! inheres in skeleton +relationship: RO:0000052 UBERON:0004288 ! inheres in skeleton [Term] id: OBA:0002344 @@ -120025,7 +219377,7 @@ synonym: "structure of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000131 ! long bone epiphysis morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0002345 @@ -120035,7 +219387,7 @@ synonym: "fragility of bone element" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002422 ! bone element structure is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:0002346 @@ -120045,7 +219397,7 @@ synonym: "size of foramen magnum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005278 ! foramen magnum morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003687 ! foramen magnum +intersection_of: RO:0000052 UBERON:0003687 ! inheres in foramen magnum [Term] id: OBA:0002347 @@ -120055,7 +219407,7 @@ synonym: "symmetry of skull" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000438 ! skull morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0003129 ! skull +intersection_of: RO:0000052 UBERON:0003129 ! inheres in skull [Term] id: OBA:0002348 @@ -120065,7 +219417,7 @@ synonym: "size of vault of skull" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000076 ! calvaria morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004339 ! vault of skull +intersection_of: RO:0000052 UBERON:0004339 ! inheres in vault of skull [Term] id: OBA:0002349 @@ -120075,7 +219427,7 @@ synonym: "amount of paranasal sinus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000172 ! paranasal sinus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001825 ! paranasal sinus +intersection_of: RO:0000052 UBERON:0001825 ! inheres in paranasal sinus [Term] id: OBA:0002350 @@ -120085,7 +219437,7 @@ synonym: "rate of immune response" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0010139 ! immune response trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006955 ! immune response +intersection_of: RO:0000052 GO:0006955 ! inheres in immune response [Term] id: OBA:0002351 @@ -120094,8 +219446,8 @@ def: "The rate of a lymphocyte apoptotic process." [AUTO:patterns/patterns/entit synonym: "rate of lymphocyte apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004174 ! apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070227 ! lymphocyte apoptotic process -relationship: inheres_in GO:0070227 ! lymphocyte apoptotic process +intersection_of: RO:0000052 GO:0070227 ! inheres in lymphocyte apoptotic process +relationship: RO:0000052 GO:0070227 ! inheres in lymphocyte apoptotic process [Term] id: OBA:0002352 @@ -120105,7 +219457,7 @@ synonym: "size of frontal sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002750 ! paranasal sinus size is_a: OBA:VT0002246 ! frontal sinus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001760 ! frontal sinus +intersection_of: RO:0000052 UBERON:0001760 ! inheres in frontal sinus [Term] id: OBA:0002353 @@ -120115,7 +219467,7 @@ synonym: "spatial pattern of trabecular bone tissue" EXACT [AUTO:patterns/patter is_a: OBA:VT0000130 ! cancellous bone morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002483 ! trabecular bone tissue +intersection_of: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue [Term] id: OBA:0002354 @@ -120125,7 +219477,7 @@ synonym: "size of compact bone tissue" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003796 ! cortical bone morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001439 ! compact bone tissue +intersection_of: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue [Term] id: OBA:0002355 @@ -120135,8 +219487,8 @@ synonym: "morphology of cartilage element" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007844 ! cartilage element -relationship: inheres_in UBERON:0007844 ! cartilage element +intersection_of: RO:0000052 UBERON:0007844 ! inheres in cartilage element +relationship: RO:0000052 UBERON:0007844 ! inheres in cartilage element [Term] id: OBA:0002356 @@ -120146,7 +219498,7 @@ synonym: "structure of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002282 ! trachea morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0002357 @@ -120156,7 +219508,7 @@ synonym: "composition of trachea" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002356 ! trachea structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0002358 @@ -120166,7 +219518,7 @@ synonym: "amount of bone resorption" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000900 ! bone resorption quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0045453 ! bone resorption +intersection_of: RO:0000052 GO:0045453 ! inheres in bone resorption [Term] id: OBA:0002359 @@ -120176,7 +219528,7 @@ synonym: "shape of metaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000133 ! long bone metaphysis morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:0002360 @@ -120186,7 +219538,7 @@ synonym: "size of trochanter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004029 ! trochanter morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000980 ! trochanter +intersection_of: RO:0000052 UBERON:0000980 ! inheres in trochanter [Term] id: OBA:0002361 @@ -120196,8 +219548,8 @@ synonym: "displaced of hip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001464 ! hip -relationship: inheres_in UBERON:0001464 ! hip +intersection_of: RO:0000052 UBERON:0001464 ! inheres in hip +relationship: RO:0000052 UBERON:0001464 ! inheres in hip [Term] id: OBA:0002362 @@ -120207,8 +219559,8 @@ synonym: "length of coccyx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000104 ! subdivision of vertebral column length is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001350 ! coccyx -relationship: inheres_in UBERON:0001350 ! coccyx +intersection_of: RO:0000052 UBERON:0001350 ! inheres in coccyx +relationship: RO:0000052 UBERON:0001350 ! inheres in coccyx [Term] id: OBA:0002363 @@ -120218,7 +219570,7 @@ synonym: "spatial pattern of bone mineralization" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0002896 ! bone mineralization trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in GO:0030282 ! bone mineralization +intersection_of: RO:0000052 GO:0030282 ! inheres in bone mineralization [Term] id: OBA:0002364 @@ -120227,8 +219579,8 @@ def: "The curvature of a metaphysis of femur." [AUTO:patterns/patterns/entity_at synonym: "curvature of metaphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002377 ! metaphysis curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0006865 ! metaphysis of femur -relationship: inheres_in UBERON:0006865 ! metaphysis of femur +intersection_of: RO:0000052 UBERON:0006865 ! inheres in metaphysis of femur +relationship: RO:0000052 UBERON:0006865 ! inheres in metaphysis of femur [Term] id: OBA:0002365 @@ -120238,7 +219590,7 @@ synonym: "spatial pattern of urinary bladder" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003741 ! viscus spatial pattern is_a: OBA:VT0000538 ! urinary bladder morphology trait intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:0002366 @@ -120248,8 +219600,8 @@ synonym: "amount of lymph node germinal center" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009039 ! lymph node germinal center -relationship: inheres_in UBERON:0009039 ! lymph node germinal center +intersection_of: RO:0000052 UBERON:0009039 ! inheres in lymph node germinal center +relationship: RO:0000052 UBERON:0009039 ! inheres in lymph node germinal center [Term] id: OBA:0002367 @@ -120259,7 +219611,7 @@ synonym: "size of iliac blade" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000410 ! iliac blade quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010746 ! iliac blade +intersection_of: RO:0000052 UBERON:0010746 ! inheres in iliac blade [Term] id: OBA:0002368 @@ -120269,7 +219621,7 @@ synonym: "curvature of iliac blade" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000410 ! iliac blade quality is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0010746 ! iliac blade +intersection_of: RO:0000052 UBERON:0010746 ! inheres in iliac blade [Term] id: OBA:0002369 @@ -120279,7 +219631,7 @@ synonym: "rate of aldehyde oxidase activity" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000689 ! aldehyde oxidase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004031 ! aldehyde oxidase activity +intersection_of: RO:0000052 GO:0004031 ! inheres in aldehyde oxidase activity [Term] id: OBA:0002370 @@ -120289,7 +219641,7 @@ synonym: "height of intervertebral disk" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004045 ! intervertebral disk size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:0002371 @@ -120299,8 +219651,8 @@ synonym: "amount of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002412 ! vertebra -relationship: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra +relationship: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0002372 @@ -120310,7 +219662,7 @@ synonym: "curvature of hindlimb zeugopod" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0003857 ! hindlimb zeugopod morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003823 ! hindlimb zeugopod +intersection_of: RO:0000052 UBERON:0003823 ! inheres in hindlimb zeugopod [Term] id: OBA:0002373 @@ -120320,8 +219672,8 @@ synonym: "size of appendage girdle complex" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010707 ! appendage girdle complex -relationship: inheres_in UBERON:0010707 ! appendage girdle complex +intersection_of: RO:0000052 UBERON:0010707 ! inheres in appendage girdle complex +relationship: RO:0000052 UBERON:0010707 ! inheres in appendage girdle complex [Term] id: OBA:0002374 @@ -120332,7 +219684,7 @@ is_a: OBA:0002651 ! long bone size is_a: OBA:0002657 ! forelimb zeugopod bone size is_a: OBA:VT0000552 ! radius morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:0002375 @@ -120342,7 +219694,7 @@ synonym: "amount of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000572 ! fibula quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:0002376 @@ -120352,8 +219704,8 @@ synonym: "displaced of patella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004786 ! bone element displaced is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002446 ! patella -relationship: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella +relationship: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:0002377 @@ -120363,7 +219715,7 @@ synonym: "curvature of metaphysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002359 ! metaphysis shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:0002378 @@ -120373,7 +219725,7 @@ synonym: "size of metaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000133 ! long bone metaphysis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:0002379 @@ -120384,7 +219736,7 @@ is_a: OBA:0002651 ! long bone size is_a: OBA:0002657 ! forelimb zeugopod bone size is_a: OBA:VT0005108 ! ulna morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002380 @@ -120394,8 +219746,8 @@ synonym: "mass density of metaphysis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001438 ! metaphysis -relationship: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis +relationship: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:0002381 @@ -120405,7 +219757,7 @@ synonym: "length of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:0002382 @@ -120415,7 +219767,7 @@ synonym: "size of tarsal region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005104 ! tarsus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004454 ! tarsal region +intersection_of: RO:0000052 UBERON:0004454 ! inheres in tarsal region [Term] id: OBA:0002383 @@ -120425,7 +219777,7 @@ synonym: "size of skeletal joint" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003754 ! skeletal joint morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0002384 @@ -120435,7 +219787,7 @@ synonym: "size of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0002187 ! fibula morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:0002385 @@ -120445,7 +219797,7 @@ synonym: "deviation of carpal region" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000554 ! carpus morphology trait is_a: PATO:0002175 ! deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0004452 ! carpal region +intersection_of: RO:0000052 UBERON:0004452 ! inheres in carpal region [Term] id: OBA:0002386 @@ -120455,7 +219807,7 @@ synonym: "size of patella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0005353 ! patella morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:0002387 @@ -120465,7 +219817,7 @@ synonym: "curvature of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003161 ! epiphysis shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0002388 @@ -120475,8 +219827,8 @@ synonym: "displaced of head of radius" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001012 ! head of radius -relationship: inheres_in UBERON:0001012 ! head of radius +intersection_of: RO:0000052 UBERON:0001012 ! inheres in head of radius +relationship: RO:0000052 UBERON:0001012 ! inheres in head of radius [Term] id: OBA:0002389 @@ -120485,8 +219837,8 @@ def: "The size of a proximal epiphysis of femur." [AUTO:patterns/patterns/entity synonym: "size of proximal epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003163 ! epiphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004412 ! proximal epiphysis of femur -relationship: inheres_in UBERON:0004412 ! proximal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur +relationship: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur [Term] id: OBA:0002390 @@ -120496,7 +219848,7 @@ synonym: "size of pubis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002413 ! pelvic girdle bone/zone size is_a: OBA:VT0010088 ! pubis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001275 ! pubis +intersection_of: RO:0000052 UBERON:0001275 ! inheres in pubis [Term] id: OBA:0002391 @@ -120506,7 +219858,7 @@ synonym: "size of ischium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002413 ! pelvic girdle bone/zone size is_a: OBA:VT0010087 ! ischium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001274 ! ischium +intersection_of: RO:0000052 UBERON:0001274 ! inheres in ischium [Term] id: OBA:0002392 @@ -120516,7 +219868,7 @@ synonym: "2-D shape of ilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002415 ! pelvic girdle bone/zone 2-D shape is_a: OBA:VT0005354 ! ilium morphology trait intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001273 ! ilium +intersection_of: RO:0000052 UBERON:0001273 ! inheres in ilium [Term] id: OBA:0002393 @@ -120526,7 +219878,7 @@ synonym: "position of acetabular part of hip bone" EXACT [AUTO:patterns/patterns is_a: OBA:1000334 ! acetabular part of hip bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001269 ! acetabular part of hip bone +intersection_of: RO:0000052 UBERON:0001269 ! inheres in acetabular part of hip bone [Term] id: OBA:0002394 @@ -120536,8 +219888,8 @@ synonym: "size of acetabular fossa" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014445 ! acetabular fossa -relationship: inheres_in UBERON:0014445 ! acetabular fossa +intersection_of: RO:0000052 UBERON:0014445 ! inheres in acetabular fossa +relationship: RO:0000052 UBERON:0014445 ! inheres in acetabular fossa [Term] id: OBA:0002395 @@ -120547,7 +219899,7 @@ synonym: "size of pubic symphysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002383 ! skeletal joint size is_a: OBA:0004782 ! pubic symphysis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003699 ! pubic symphysis +intersection_of: RO:0000052 UBERON:0003699 ! inheres in pubic symphysis [Term] id: OBA:0002396 @@ -120557,7 +219909,7 @@ synonym: "spatial pattern of nipple" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0006078 ! nipple morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:0002397 @@ -120567,7 +219919,7 @@ synonym: "length of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002083 ! nose size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0002398 @@ -120577,8 +219929,8 @@ synonym: "concavity of ala of nose" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0015066 ! surface structure morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0006906 ! ala of nose -relationship: inheres_in UBERON:0006906 ! ala of nose +intersection_of: RO:0000052 UBERON:0006906 ! inheres in ala of nose +relationship: RO:0000052 UBERON:0006906 ! inheres in ala of nose [Term] id: OBA:0002399 @@ -120588,7 +219940,7 @@ synonym: "length of nasal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002090 ! nasal bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001681 ! nasal bone +intersection_of: RO:0000052 UBERON:0001681 ! inheres in nasal bone [Term] id: OBA:0002400 @@ -120598,8 +219950,8 @@ synonym: "damage of musculature" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001020 ! damage intersection_of: PATO:0001020 ! damage -intersection_of: inheres_in UBERON:0001015 ! musculature -relationship: inheres_in UBERON:0001015 ! musculature +intersection_of: RO:0000052 UBERON:0001015 ! inheres in musculature +relationship: RO:0000052 UBERON:0001015 ! inheres in musculature [Term] id: OBA:0002401 @@ -120609,8 +219961,8 @@ synonym: "mass of muscle organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0002402 @@ -120619,8 +219971,8 @@ def: "The size of a skeletal musculature." [AUTO:patterns/patterns/entity_attrib synonym: "size of skeletal musculature" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0018254 ! skeletal musculature -relationship: inheres_in UBERON:0018254 ! skeletal musculature +intersection_of: RO:0000052 UBERON:0018254 ! inheres in skeletal musculature +relationship: RO:0000052 UBERON:0018254 ! inheres in skeletal musculature [Term] id: OBA:0002403 @@ -120630,7 +219982,7 @@ synonym: "composition of artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003389 ! artery structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001637 ! artery +intersection_of: RO:0000052 UBERON:0001637 ! inheres in artery [Term] id: OBA:0002404 @@ -120640,8 +219992,8 @@ synonym: "rate of pyruvate carboxylase activity" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004736 ! pyruvate carboxylase activity -relationship: inheres_in GO:0004736 ! pyruvate carboxylase activity +intersection_of: RO:0000052 GO:0004736 ! inheres in pyruvate carboxylase activity +relationship: RO:0000052 GO:0004736 ! inheres in pyruvate carboxylase activity [Term] id: OBA:0002405 @@ -120651,8 +220003,8 @@ synonym: "duration of G2 phase" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in GO:0051319 ! G2 phase -relationship: inheres_in GO:0051319 ! G2 phase +intersection_of: RO:0000052 GO:0051319 ! inheres in G2 phase +relationship: RO:0000052 GO:0051319 ! inheres in G2 phase [Term] id: OBA:0002406 @@ -120662,8 +220014,8 @@ synonym: "position of raphe of scrotum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0017732 ! raphe of scrotum -relationship: inheres_in UBERON:0017732 ! raphe of scrotum +intersection_of: RO:0000052 UBERON:0017732 ! inheres in raphe of scrotum +relationship: RO:0000052 UBERON:0017732 ! inheres in raphe of scrotum [Term] id: OBA:0002407 @@ -120672,8 +220024,8 @@ def: "The size of a external genitalia." [AUTO:patterns/patterns/entity_attribut synonym: "size of external genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004176 ! external genitalia -relationship: inheres_in UBERON:0004176 ! external genitalia +intersection_of: RO:0000052 UBERON:0004176 ! inheres in external genitalia +relationship: RO:0000052 UBERON:0004176 ! inheres in external genitalia [Term] id: OBA:0002408 @@ -120683,8 +220035,8 @@ synonym: "amount of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000996 ! vagina -relationship: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina +relationship: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0002409 @@ -120695,7 +220047,7 @@ is_a: OBA:0003742 ! anatomical system position is_a: OBA:VT0005389 ! reproductive system trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000990 ! reproductive system +intersection_of: RO:0000052 UBERON:0000990 ! inheres in reproductive system [Term] id: OBA:0002410 @@ -120705,8 +220057,8 @@ synonym: "rate of glyoxalase III activity" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0019172 ! glyoxalase III activity -relationship: inheres_in GO:0019172 ! glyoxalase III activity +intersection_of: RO:0000052 GO:0019172 ! inheres in glyoxalase III activity +relationship: RO:0000052 GO:0019172 ! inheres in glyoxalase III activity [Term] id: OBA:0002411 @@ -120716,7 +220068,7 @@ synonym: "size of abdomen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000625 ! abdomen quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000916 ! abdomen +intersection_of: RO:0000052 UBERON:0000916 ! inheres in abdomen [Term] id: OBA:0002412 @@ -120726,7 +220078,7 @@ synonym: "size of acetabular part of hip bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000334 ! acetabular part of hip bone quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001269 ! acetabular part of hip bone +intersection_of: RO:0000052 UBERON:0001269 ! inheres in acetabular part of hip bone [Term] id: OBA:0002413 @@ -120736,7 +220088,7 @@ synonym: "size of pelvic girdle bone/zone" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007830 ! pelvic girdle bone/zone +intersection_of: RO:0000052 UBERON:0007830 ! inheres in pelvic girdle bone/zone [Term] id: OBA:0002414 @@ -120746,7 +220098,7 @@ synonym: "structure of iliac blade" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000410 ! iliac blade quality is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0010746 ! iliac blade +intersection_of: RO:0000052 UBERON:0010746 ! inheres in iliac blade [Term] id: OBA:0002415 @@ -120756,7 +220108,7 @@ synonym: "2-D shape of pelvic girdle bone/zone" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0007830 ! pelvic girdle bone/zone +intersection_of: RO:0000052 UBERON:0007830 ! inheres in pelvic girdle bone/zone [Term] id: OBA:0002416 @@ -120766,7 +220118,7 @@ synonym: "convex 3-D shape of bony vertebral centrum" EXACT [AUTO:patterns/patte is_a: OBA:VT0000141 ! vertebral body morphology trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002417 @@ -120776,7 +220128,7 @@ synonym: "mass density of vertebral endplate" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000479 ! vertebral endplate quality is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0014386 ! vertebral endplate +intersection_of: RO:0000052 UBERON:0014386 ! inheres in vertebral endplate [Term] id: OBA:0002418 @@ -120787,8 +220139,8 @@ is_a: OBA:0002829 ! vertebra shape is_a: OBA:1000660 ! trunk or cervical vertebra quality is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0011677 ! trunk vertebra -relationship: inheres_in UBERON:0011677 ! trunk vertebra +intersection_of: RO:0000052 UBERON:0011677 ! inheres in trunk vertebra +relationship: RO:0000052 UBERON:0011677 ! inheres in trunk vertebra [Term] id: OBA:0002419 @@ -120798,7 +220150,7 @@ synonym: "size of odontoid process of cervical vertebra 2" EXACT [AUTO:patterns/ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000235 ! odontoid process of cervical vertebra 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004096 ! odontoid process of cervical vertebra 2 +intersection_of: RO:0000052 UBERON:0004096 ! inheres in odontoid process of cervical vertebra 2 [Term] id: OBA:0002420 @@ -120808,8 +220160,8 @@ synonym: "mobility of cervical vertebra" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000660 ! trunk or cervical vertebra quality is_a: PATO:0000004 ! mobility intersection_of: PATO:0000004 ! mobility -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra -relationship: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra +relationship: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0002421 @@ -120818,8 +220170,8 @@ def: "The strength of a axial muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "strength of axial muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0003897 ! axial muscle -relationship: inheres_in UBERON:0003897 ! axial muscle +intersection_of: RO:0000052 UBERON:0003897 ! inheres in axial muscle +relationship: RO:0000052 UBERON:0003897 ! inheres in axial muscle [Term] id: OBA:0002422 @@ -120829,7 +220181,7 @@ synonym: "structure of bone element" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0010003 ! bone morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:0002423 @@ -120839,8 +220191,8 @@ synonym: "rate of cholesterol esterification" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0034435 ! cholesterol esterification -relationship: inheres_in GO:0034435 ! cholesterol esterification +intersection_of: RO:0000052 GO:0034435 ! inheres in cholesterol esterification +relationship: RO:0000052 GO:0034435 ! inheres in cholesterol esterification [Term] id: OBA:0002424 @@ -120850,8 +220202,8 @@ synonym: "rate of propionyl-CoA carboxylase activity" EXACT [AUTO:patterns/patte is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004658 ! propionyl-CoA carboxylase activity -relationship: inheres_in GO:0004658 ! propionyl-CoA carboxylase activity +intersection_of: RO:0000052 GO:0004658 ! inheres in propionyl-CoA carboxylase activity +relationship: RO:0000052 GO:0004658 ! inheres in propionyl-CoA carboxylase activity [Term] id: OBA:0002425 @@ -120860,8 +220212,8 @@ def: "The curvature of a proximal epiphysis of femur." [AUTO:patterns/patterns/e synonym: "curvature of proximal epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002387 ! epiphysis curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004412 ! proximal epiphysis of femur -relationship: inheres_in UBERON:0004412 ! proximal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur +relationship: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur [Term] id: OBA:0002426 @@ -120871,7 +220223,7 @@ synonym: "size of greater sciatic notch" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000159 ! greater sciatic notch quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014411 ! greater sciatic notch +intersection_of: RO:0000052 UBERON:0014411 ! inheres in greater sciatic notch [Term] id: OBA:0002427 @@ -120880,8 +220232,8 @@ def: "The strength of a first dorsal interosseous of manus." [AUTO:patterns/patt synonym: "strength of first dorsal interosseous of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000081 ! forelimb muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0002988 ! first dorsal interosseous of manus -relationship: inheres_in UBERON:0002988 ! first dorsal interosseous of manus +intersection_of: RO:0000052 UBERON:0002988 ! inheres in first dorsal interosseous of manus +relationship: RO:0000052 UBERON:0002988 ! inheres in first dorsal interosseous of manus [Term] id: OBA:0002428 @@ -120891,8 +220243,8 @@ synonym: "size of thenar muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0010647 ! forelimb muscle morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014376 ! thenar muscle -relationship: inheres_in UBERON:0014376 ! thenar muscle +intersection_of: RO:0000052 UBERON:0014376 ! inheres in thenar muscle +relationship: RO:0000052 UBERON:0014376 ! inheres in thenar muscle [Term] id: OBA:0002429 @@ -120902,7 +220254,7 @@ synonym: "structure of nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001021 ! nerve +intersection_of: RO:0000052 UBERON:0001021 ! inheres in nerve [Term] id: OBA:0002430 @@ -120911,8 +220263,8 @@ def: "The mass density of a proximal metaphysis of femur." [AUTO:patterns/patter synonym: "mass density of proximal metaphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002380 ! metaphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0006863 ! proximal metaphysis of femur -relationship: inheres_in UBERON:0006863 ! proximal metaphysis of femur +intersection_of: RO:0000052 UBERON:0006863 ! inheres in proximal metaphysis of femur +relationship: RO:0000052 UBERON:0006863 ! inheres in proximal metaphysis of femur [Term] id: OBA:0002431 @@ -120922,7 +220274,7 @@ synonym: "structure of central canal of spinal cord" EXACT [AUTO:patterns/patter is_a: OBA:0004819 ! central canal of spinal cord morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002291 ! central canal of spinal cord +intersection_of: RO:0000052 UBERON:0002291 ! inheres in central canal of spinal cord [Term] id: OBA:0002432 @@ -120931,8 +220283,8 @@ def: "The size of a first dorsal interosseous of manus." [AUTO:patterns/patterns synonym: "size of first dorsal interosseous of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002763 ! interosseous muscle of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002988 ! first dorsal interosseous of manus -relationship: inheres_in UBERON:0002988 ! first dorsal interosseous of manus +intersection_of: RO:0000052 UBERON:0002988 ! inheres in first dorsal interosseous of manus +relationship: RO:0000052 UBERON:0002988 ! inheres in first dorsal interosseous of manus [Term] id: OBA:0002433 @@ -120941,8 +220293,8 @@ def: "The strength of a thenar muscle." [AUTO:patterns/patterns/entity_attribute synonym: "strength of thenar muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000081 ! forelimb muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0014376 ! thenar muscle -relationship: inheres_in UBERON:0014376 ! thenar muscle +intersection_of: RO:0000052 UBERON:0014376 ! inheres in thenar muscle +relationship: RO:0000052 UBERON:0014376 ! inheres in thenar muscle [Term] id: OBA:0002434 @@ -120952,8 +220304,8 @@ synonym: "position of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0003690 ! fused sacrum -relationship: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum +relationship: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0002435 @@ -120963,7 +220315,7 @@ synonym: "onset quality of chromosome condensation" EXACT [AUTO:patterns/pattern is_a: OBA:1000311 ! chromosome condensation quality is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0030261 ! chromosome condensation +intersection_of: RO:0000052 GO:0030261 ! inheres in chromosome condensation [Term] id: OBA:0002436 @@ -120973,8 +220325,8 @@ synonym: "amount of peripheral nervous system myelin formation" EXACT [AUTO:patt is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0032290 ! peripheral nervous system myelin formation -relationship: inheres_in GO:0032290 ! peripheral nervous system myelin formation +intersection_of: RO:0000052 GO:0032290 ! inheres in peripheral nervous system myelin formation +relationship: RO:0000052 GO:0032290 ! inheres in peripheral nervous system myelin formation [Term] id: OBA:0002437 @@ -120984,8 +220336,8 @@ synonym: "strength of musculature of upper limb" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0004481 ! musculature of upper limb -relationship: inheres_in UBERON:0004481 ! musculature of upper limb +intersection_of: RO:0000052 UBERON:0004481 ! inheres in musculature of upper limb +relationship: RO:0000052 UBERON:0004481 ! inheres in musculature of upper limb [Term] id: OBA:0002438 @@ -120996,8 +220348,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002100 ! trunk -relationship: inheres_in UBERON:0002100 ! trunk +intersection_of: RO:0000052 UBERON:0002100 ! inheres in trunk +relationship: RO:0000052 UBERON:0002100 ! inheres in trunk [Term] id: OBA:0002439 @@ -121007,8 +220359,8 @@ synonym: "rate of xanthine dehydrogenase activity" EXACT [AUTO:patterns/patterns is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004854 ! xanthine dehydrogenase activity -relationship: inheres_in GO:0004854 ! xanthine dehydrogenase activity +intersection_of: RO:0000052 GO:0004854 ! inheres in xanthine dehydrogenase activity +relationship: RO:0000052 GO:0004854 ! inheres in xanthine dehydrogenase activity [Term] id: OBA:0002440 @@ -121017,8 +220369,8 @@ def: "The strength of a muscle of pectoral girdle." [AUTO:patterns/patterns/enti synonym: "strength of muscle of pectoral girdle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0008196 ! muscle of pectoral girdle -relationship: inheres_in UBERON:0008196 ! muscle of pectoral girdle +intersection_of: RO:0000052 UBERON:0008196 ! inheres in muscle of pectoral girdle +relationship: RO:0000052 UBERON:0008196 ! inheres in muscle of pectoral girdle [Term] id: OBA:0002441 @@ -121028,8 +220380,8 @@ synonym: "flexibility of muscle organ" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001543 ! flexibility intersection_of: PATO:0001543 ! flexibility -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0002442 @@ -121039,8 +220391,8 @@ synonym: "variability of size of cell of skeletal muscle" EXACT [AUTO:patterns/p is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001956 ! variability of size intersection_of: PATO:0001956 ! variability of size -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle -relationship: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle +relationship: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:0002443 @@ -121050,8 +220402,8 @@ synonym: "rate of glucose-6-phosphate isomerase activity" EXACT [AUTO:patterns/p is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004347 ! glucose-6-phosphate isomerase activity -relationship: inheres_in GO:0004347 ! glucose-6-phosphate isomerase activity +intersection_of: RO:0000052 GO:0004347 ! inheres in glucose-6-phosphate isomerase activity +relationship: RO:0000052 GO:0004347 ! inheres in glucose-6-phosphate isomerase activity [Term] id: OBA:0002444 @@ -121061,8 +220413,8 @@ synonym: "amount of foam cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000891 ! foam cell -relationship: inheres_in CL:0000891 ! foam cell +intersection_of: RO:0000052 CL:0000891 ! inheres in foam cell +relationship: RO:0000052 CL:0000891 ! inheres in foam cell [Term] id: OBA:0002445 @@ -121072,8 +220424,8 @@ synonym: "rate of dihydropyrimidine dehydrogenase (NADP+) activity" EXACT [AUTO: is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0017113 ! dihydropyrimidine dehydrogenase (NADP+) activity -relationship: inheres_in GO:0017113 ! dihydropyrimidine dehydrogenase (NADP+) activity +intersection_of: RO:0000052 GO:0017113 ! inheres in dihydropyrimidine dehydrogenase (NADP+) activity +relationship: RO:0000052 GO:0017113 ! inheres in dihydropyrimidine dehydrogenase (NADP+) activity [Term] id: OBA:0002446 @@ -121083,8 +220435,8 @@ synonym: "rate of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltran is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008455 ! alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity -relationship: inheres_in GO:0008455 ! alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +intersection_of: RO:0000052 GO:0008455 ! inheres in alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +relationship: RO:0000052 GO:0008455 ! inheres in alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity [Term] id: OBA:0002447 @@ -121093,8 +220445,8 @@ def: "The size of a musculature of pectoral girdle." [AUTO:patterns/patterns/ent synonym: "size of musculature of pectoral girdle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004471 ! musculature of pectoral girdle -relationship: inheres_in UBERON:0004471 ! musculature of pectoral girdle +intersection_of: RO:0000052 UBERON:0004471 ! inheres in musculature of pectoral girdle +relationship: RO:0000052 UBERON:0004471 ! inheres in musculature of pectoral girdle [Term] id: OBA:0002448 @@ -121103,8 +220455,8 @@ def: "The strength of a quadriceps femoris." [AUTO:patterns/patterns/entity_attr synonym: "strength of quadriceps femoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000082 ! hindlimb muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001377 ! quadriceps femoris -relationship: inheres_in UBERON:0001377 ! quadriceps femoris +intersection_of: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris +relationship: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris [Term] id: OBA:0002449 @@ -121114,8 +220466,8 @@ synonym: "size of hindlimb stylopod muscle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002873 ! pelvic complex muscle size is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004252 ! hindlimb stylopod muscle -relationship: inheres_in UBERON:0004252 ! hindlimb stylopod muscle +intersection_of: RO:0000052 UBERON:0004252 ! inheres in hindlimb stylopod muscle +relationship: RO:0000052 UBERON:0004252 ! inheres in hindlimb stylopod muscle [Term] id: OBA:0002450 @@ -121124,8 +220476,8 @@ def: "The strength of a muscle of pelvic girdle." [AUTO:patterns/patterns/entity synonym: "strength of muscle of pelvic girdle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002770 ! pelvic complex muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001497 ! muscle of pelvic girdle -relationship: inheres_in UBERON:0001497 ! muscle of pelvic girdle +intersection_of: RO:0000052 UBERON:0001497 ! inheres in muscle of pelvic girdle +relationship: RO:0000052 UBERON:0001497 ! inheres in muscle of pelvic girdle [Term] id: OBA:0002451 @@ -121136,7 +220488,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005002 ! mandibular ramus morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000401 ! mandibular ramus +intersection_of: RO:0000052 UBERON:0000401 ! inheres in mandibular ramus [Term] id: OBA:0002452 @@ -121146,7 +220498,7 @@ synonym: "length of middle phalanx of pes" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002588 ! phalanx of pes length is_a: OBA:0003083 ! middle phalanx of pes size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:0002453 @@ -121156,8 +220508,8 @@ synonym: "mass density of iliac crest" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0014437 ! iliac crest -relationship: inheres_in UBERON:0014437 ! iliac crest +intersection_of: RO:0000052 UBERON:0014437 ! inheres in iliac crest +relationship: RO:0000052 UBERON:0014437 ! inheres in iliac crest [Term] id: OBA:0002454 @@ -121166,8 +220518,8 @@ def: "The size of a musculature of limb." [AUTO:patterns/patterns/entity_attribu synonym: "size of musculature of limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004480 ! musculature of limb -relationship: inheres_in UBERON:0004480 ! musculature of limb +intersection_of: RO:0000052 UBERON:0004480 ! inheres in musculature of limb +relationship: RO:0000052 UBERON:0004480 ! inheres in musculature of limb [Term] id: OBA:0002455 @@ -121176,8 +220528,8 @@ def: "The onset quality of a death stage." [AUTO:patterns/patterns/entity_attrib synonym: "onset quality of death stage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0000071 ! death stage -relationship: inheres_in UBERON:0000071 ! death stage +intersection_of: RO:0000052 UBERON:0000071 ! inheres in death stage +relationship: RO:0000052 UBERON:0000071 ! inheres in death stage [Term] id: OBA:0002456 @@ -121187,8 +220539,8 @@ synonym: "displaced of shoulder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001467 ! shoulder -relationship: inheres_in UBERON:0001467 ! shoulder +intersection_of: RO:0000052 UBERON:0001467 ! inheres in shoulder +relationship: RO:0000052 UBERON:0001467 ! inheres in shoulder [Term] id: OBA:0002457 @@ -121198,7 +220550,7 @@ synonym: "concavity of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002459 ! humerus shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:0002458 @@ -121209,7 +220561,7 @@ is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0005296 ! humerus morphology trait is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:0002459 @@ -121219,7 +220571,7 @@ synonym: "shape of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0005296 ! humerus morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:0002460 @@ -121229,7 +220581,7 @@ synonym: "sharpness of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002459 ! humerus shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:0002461 @@ -121239,7 +220591,7 @@ synonym: "2-D shape of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002459 ! humerus shape is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:0002462 @@ -121249,7 +220601,7 @@ synonym: "position of deltopectoral crest" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000272 ! deltopectoral crest quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002498 ! deltopectoral crest +intersection_of: RO:0000052 UBERON:0002498 ! inheres in deltopectoral crest [Term] id: OBA:0002463 @@ -121258,8 +220610,8 @@ def: "The curvature of a epiphysis of humerus." [AUTO:patterns/patterns/entity_a synonym: "curvature of epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002387 ! epiphysis curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004382 ! epiphysis of humerus -relationship: inheres_in UBERON:0004382 ! epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus +relationship: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus [Term] id: OBA:0002464 @@ -121268,8 +220620,8 @@ def: "The mass density of a epiphysis of humerus." [AUTO:patterns/patterns/entit synonym: "mass density of epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003164 ! epiphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004382 ! epiphysis of humerus -relationship: inheres_in UBERON:0004382 ! epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus +relationship: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus [Term] id: OBA:0002465 @@ -121278,8 +220630,8 @@ def: "The size of a epiphysis of humerus." [AUTO:patterns/patterns/entity_attrib synonym: "size of epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003163 ! epiphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004382 ! epiphysis of humerus -relationship: inheres_in UBERON:0004382 ! epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus +relationship: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus [Term] id: OBA:0002466 @@ -121288,8 +220640,8 @@ def: "The 2-D shape of a epiphysis of humerus." [AUTO:patterns/patterns/entity_a synonym: "2-D shape of epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003165 ! epiphysis 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004382 ! epiphysis of humerus -relationship: inheres_in UBERON:0004382 ! epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus +relationship: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus [Term] id: OBA:0002467 @@ -121298,8 +220650,8 @@ def: "The spatial pattern of a epiphysis of humerus." [AUTO:patterns/patterns/en synonym: "spatial pattern of epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003170 ! epiphysis spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004382 ! epiphysis of humerus -relationship: inheres_in UBERON:0004382 ! epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus +relationship: RO:0000052 UBERON:0004382 ! inheres in epiphysis of humerus [Term] id: OBA:0002468 @@ -121308,8 +220660,8 @@ def: "The size of a metaphysis of humerus." [AUTO:patterns/patterns/entity_attri synonym: "size of metaphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002378 ! metaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013749 ! metaphysis of humerus -relationship: inheres_in UBERON:0013749 ! metaphysis of humerus +intersection_of: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus +relationship: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus [Term] id: OBA:0002469 @@ -121319,7 +220671,7 @@ synonym: "curvature of metaphysis of humerus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002377 ! metaphysis curvature is_a: OBA:0002471 ! metaphysis of humerus shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0013749 ! metaphysis of humerus +intersection_of: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus [Term] id: OBA:0002470 @@ -121329,7 +220681,7 @@ synonym: "sharpness of metaphysis of humerus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002471 ! metaphysis of humerus shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0013749 ! metaphysis of humerus +intersection_of: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus [Term] id: OBA:0002471 @@ -121338,8 +220690,8 @@ def: "The shape of a metaphysis of humerus." [AUTO:patterns/patterns/entity_attr synonym: "shape of metaphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002359 ! metaphysis shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0013749 ! metaphysis of humerus -relationship: inheres_in UBERON:0013749 ! metaphysis of humerus +intersection_of: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus +relationship: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus [Term] id: OBA:0002472 @@ -121349,7 +220701,7 @@ synonym: "2-D shape of metaphysis of humerus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002471 ! metaphysis of humerus shape is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0013749 ! metaphysis of humerus +intersection_of: RO:0000052 UBERON:0013749 ! inheres in metaphysis of humerus [Term] id: OBA:0002473 @@ -121359,8 +220711,8 @@ synonym: "shape of humerus diaphysis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0004214 ! long bone diaphysis morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004652 ! humerus diaphysis -relationship: inheres_in UBERON:0004652 ! humerus diaphysis +intersection_of: RO:0000052 UBERON:0004652 ! inheres in humerus diaphysis +relationship: RO:0000052 UBERON:0004652 ! inheres in humerus diaphysis [Term] id: OBA:0002474 @@ -121369,8 +220721,8 @@ def: "The size of a humerus diaphysis." [AUTO:patterns/patterns/entity_attribute synonym: "size of humerus diaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002587 ! diaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004652 ! humerus diaphysis -relationship: inheres_in UBERON:0004652 ! humerus diaphysis +intersection_of: RO:0000052 UBERON:0004652 ! inheres in humerus diaphysis +relationship: RO:0000052 UBERON:0004652 ! inheres in humerus diaphysis [Term] id: OBA:0002475 @@ -121380,7 +220732,7 @@ synonym: "size of joint space of elbow" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000237 ! joint space of elbow quality is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004099 ! joint space of elbow +intersection_of: RO:0000052 UBERON:0004099 ! inheres in joint space of elbow [Term] id: OBA:0002476 @@ -121390,8 +220742,8 @@ synonym: "amount of forelimb zeugopod bone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone -relationship: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone +relationship: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0002477 @@ -121401,7 +220753,7 @@ synonym: "curvature of forelimb zeugopod bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002478 ! forelimb zeugopod bone morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0002478 @@ -121411,8 +220763,8 @@ synonym: "morphology of forelimb zeugopod bone" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone -relationship: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone +relationship: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0002479 @@ -121423,7 +220775,7 @@ is_a: OBA:0002422 ! bone element structure is_a: OBA:0002478 ! forelimb zeugopod bone morphology is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0002480 @@ -121433,7 +220785,7 @@ synonym: "size of radio-ulnar joint" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002603 ! synovial joint size is_a: OBA:1000470 ! radio-ulnar joint quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001528 ! radio-ulnar joint +intersection_of: RO:0000052 UBERON:0001528 ! inheres in radio-ulnar joint [Term] id: OBA:0002481 @@ -121443,7 +220795,7 @@ synonym: "amount of radius bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002476 ! forelimb zeugopod bone amount is_a: OBA:1000591 ! radius bone quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:0002482 @@ -121453,7 +220805,7 @@ synonym: "structure of radius bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000552 ! radius morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:0002483 @@ -121463,7 +220815,7 @@ synonym: "wholeness of radius bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002479 ! forelimb zeugopod bone wholeness is_a: OBA:0002482 ! radius bone structure intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:0002484 @@ -121473,7 +220825,7 @@ synonym: "amount of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002476 ! forelimb zeugopod bone amount is_a: OBA:1000300 ! ulna quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002485 @@ -121483,7 +220835,7 @@ synonym: "displaced of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004786 ! bone element displaced is_a: OBA:1000300 ! ulna quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002486 @@ -121493,7 +220845,7 @@ synonym: "wholeness of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002479 ! forelimb zeugopod bone wholeness is_a: OBA:VT0005108 ! ulna morphology trait intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002487 @@ -121503,7 +220855,7 @@ synonym: "concavity of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002489 ! ulna shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002488 @@ -121513,7 +220865,7 @@ synonym: "sharpness of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002489 ! ulna shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002489 @@ -121523,7 +220875,7 @@ synonym: "shape of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0005108 ! ulna morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:0002490 @@ -121533,8 +220885,8 @@ synonym: "displaced of carpal region" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0004452 ! carpal region -relationship: inheres_in UBERON:0004452 ! carpal region +intersection_of: RO:0000052 UBERON:0004452 ! inheres in carpal region +relationship: RO:0000052 UBERON:0004452 ! inheres in carpal region [Term] id: OBA:0002491 @@ -121543,8 +220895,8 @@ def: "The size of a head of radius." [AUTO:patterns/patterns/entity_attribute] synonym: "size of head of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001012 ! head of radius -relationship: inheres_in UBERON:0001012 ! head of radius +intersection_of: RO:0000052 UBERON:0001012 ! inheres in head of radius +relationship: RO:0000052 UBERON:0001012 ! inheres in head of radius [Term] id: OBA:0002492 @@ -121554,8 +220906,8 @@ synonym: "structure of neck of radius" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000199 ! neck of radius -relationship: inheres_in UBERON:0000199 ! neck of radius +intersection_of: RO:0000052 UBERON:0000199 ! inheres in neck of radius +relationship: RO:0000052 UBERON:0000199 ! inheres in neck of radius [Term] id: OBA:0002493 @@ -121565,7 +220917,7 @@ synonym: "convex 3-D shape of epiphysis of radius" EXACT [AUTO:patterns/patterns is_a: OBA:0002498 ! epiphysis of radius shape is_a: OBA:0003162 ! epiphysis convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002494 @@ -121575,7 +220927,7 @@ synonym: "curvature of epiphysis of radius" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002387 ! epiphysis curvature is_a: OBA:0002498 ! epiphysis of radius shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002495 @@ -121584,8 +220936,8 @@ def: "The mass density of a epiphysis of radius." [AUTO:patterns/patterns/entity synonym: "mass density of epiphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003164 ! epiphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius -relationship: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius +relationship: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002496 @@ -121594,8 +220946,8 @@ def: "The size of a epiphysis of radius." [AUTO:patterns/patterns/entity_attribu synonym: "size of epiphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003163 ! epiphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius -relationship: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius +relationship: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002497 @@ -121605,7 +220957,7 @@ synonym: "2-D shape of epiphysis of radius" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002498 ! epiphysis of radius shape is_a: OBA:0003165 ! epiphysis 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002498 @@ -121614,8 +220966,8 @@ def: "The shape of a epiphysis of radius." [AUTO:patterns/patterns/entity_attrib synonym: "shape of epiphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003161 ! epiphysis shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004385 ! epiphysis of radius -relationship: inheres_in UBERON:0004385 ! epiphysis of radius +intersection_of: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius +relationship: RO:0000052 UBERON:0004385 ! inheres in epiphysis of radius [Term] id: OBA:0002499 @@ -121624,8 +220976,8 @@ def: "The size of a epiphyseal plate of radius." [AUTO:patterns/patterns/entity_ synonym: "size of epiphyseal plate of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004254 ! epiphyseal plate size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016425 ! epiphyseal plate of radius -relationship: inheres_in UBERON:0016425 ! epiphyseal plate of radius +intersection_of: RO:0000052 UBERON:0016425 ! inheres in epiphyseal plate of radius +relationship: RO:0000052 UBERON:0016425 ! inheres in epiphyseal plate of radius [Term] id: OBA:0002500 @@ -121635,7 +220987,7 @@ synonym: "curvature of metaphysis of radius" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002377 ! metaphysis curvature is_a: OBA:0002502 ! metaphysis of radius shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0013751 ! metaphysis of radius +intersection_of: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius [Term] id: OBA:0002501 @@ -121644,8 +220996,8 @@ def: "The mass density of a metaphysis of radius." [AUTO:patterns/patterns/entit synonym: "mass density of metaphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002380 ! metaphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0013751 ! metaphysis of radius -relationship: inheres_in UBERON:0013751 ! metaphysis of radius +intersection_of: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius +relationship: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius [Term] id: OBA:0002502 @@ -121654,8 +221006,8 @@ def: "The shape of a metaphysis of radius." [AUTO:patterns/patterns/entity_attri synonym: "shape of metaphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002359 ! metaphysis shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0013751 ! metaphysis of radius -relationship: inheres_in UBERON:0013751 ! metaphysis of radius +intersection_of: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius +relationship: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius [Term] id: OBA:0002503 @@ -121664,8 +221016,8 @@ def: "The size of a metaphysis of radius." [AUTO:patterns/patterns/entity_attrib synonym: "size of metaphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002378 ! metaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013751 ! metaphysis of radius -relationship: inheres_in UBERON:0013751 ! metaphysis of radius +intersection_of: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius +relationship: RO:0000052 UBERON:0013751 ! inheres in metaphysis of radius [Term] id: OBA:0002504 @@ -121675,8 +221027,8 @@ synonym: "curvature of olecranon" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0006810 ! olecranon -relationship: inheres_in UBERON:0006810 ! olecranon +intersection_of: RO:0000052 UBERON:0006810 ! inheres in olecranon +relationship: RO:0000052 UBERON:0006810 ! inheres in olecranon [Term] id: OBA:0002505 @@ -121686,8 +221038,8 @@ synonym: "mass density of olecranon" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0006810 ! olecranon -relationship: inheres_in UBERON:0006810 ! olecranon +intersection_of: RO:0000052 UBERON:0006810 ! inheres in olecranon +relationship: RO:0000052 UBERON:0006810 ! inheres in olecranon [Term] id: OBA:0002506 @@ -121698,7 +221050,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000279 ! styloid process of ulna quality is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0011575 ! styloid process of ulna +intersection_of: RO:0000052 UBERON:0011575 ! inheres in styloid process of ulna [Term] id: OBA:0002507 @@ -121707,8 +221059,8 @@ def: "The mass density of a ulnar metaphysis." [AUTO:patterns/patterns/entity_at synonym: "mass density of ulnar metaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002380 ! metaphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0013748 ! ulnar metaphysis -relationship: inheres_in UBERON:0013748 ! ulnar metaphysis +intersection_of: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis +relationship: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis [Term] id: OBA:0002508 @@ -121718,7 +221070,7 @@ synonym: "sharpness of ulnar metaphysis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0002509 ! ulnar metaphysis shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0013748 ! ulnar metaphysis +intersection_of: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis [Term] id: OBA:0002509 @@ -121727,8 +221079,8 @@ def: "The shape of a ulnar metaphysis." [AUTO:patterns/patterns/entity_attribute synonym: "shape of ulnar metaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002359 ! metaphysis shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0013748 ! ulnar metaphysis -relationship: inheres_in UBERON:0013748 ! ulnar metaphysis +intersection_of: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis +relationship: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis [Term] id: OBA:0002510 @@ -121737,8 +221089,8 @@ def: "The size of a ulnar metaphysis." [AUTO:patterns/patterns/entity_attribute] synonym: "size of ulnar metaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002378 ! metaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013748 ! ulnar metaphysis -relationship: inheres_in UBERON:0013748 ! ulnar metaphysis +intersection_of: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis +relationship: RO:0000052 UBERON:0013748 ! inheres in ulnar metaphysis [Term] id: OBA:0002511 @@ -121748,8 +221100,8 @@ synonym: "amount of skeleton of manus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001442 ! skeleton of manus -relationship: inheres_in UBERON:0001442 ! skeleton of manus +intersection_of: RO:0000052 UBERON:0001442 ! inheres in skeleton of manus +relationship: RO:0000052 UBERON:0001442 ! inheres in skeleton of manus [Term] id: OBA:0002512 @@ -121759,7 +221111,7 @@ synonym: "curvature of manual digit" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002196 ! manual digit shape is_a: OBA:0004212 ! digit curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002513 @@ -121768,8 +221120,8 @@ def: "The deviation of a manual digit." [AUTO:patterns/patterns/entity_attribute synonym: "deviation of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003339 ! digit deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0002389 ! manual digit -relationship: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit +relationship: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002514 @@ -121779,7 +221131,7 @@ synonym: "length of distal phalanx of manual digit 3" EXACT [AUTO:patterns/patte is_a: OBA:0002939 ! distal phalanx of manual digit 3 size is_a: OBA:0003016 ! distal phalanx of manus length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:0002515 @@ -121788,8 +221140,8 @@ def: "The deviation of a manual digit 5." [AUTO:patterns/patterns/entity_attribu synonym: "deviation of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002513 ! manual digit deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003625 ! manual digit 5 -relationship: inheres_in UBERON:0003625 ! manual digit 5 +intersection_of: RO:0000052 UBERON:0003625 ! inheres in manual digit 5 +relationship: RO:0000052 UBERON:0003625 ! inheres in manual digit 5 [Term] id: OBA:0002516 @@ -121798,8 +221150,8 @@ def: "The curvature of a manual digit 5 phalanx." [AUTO:patterns/patterns/entity synonym: "curvature of manual digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003001 ! phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003639 ! manual digit 5 phalanx -relationship: inheres_in UBERON:0003639 ! manual digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx +relationship: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx [Term] id: OBA:0002517 @@ -121809,7 +221161,7 @@ synonym: "length of middle phalanx of manual digit 5" EXACT [AUTO:patterns/patte is_a: OBA:0002661 ! middle phalanx of manus length is_a: OBA:0002895 ! middle phalanx of manual digit 5 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:0002518 @@ -121820,7 +221172,7 @@ is_a: OBA:0002516 ! manual digit 5 phalanx curvature is_a: OBA:0003008 ! distal phalanx of manus curvature is_a: OBA:1000271 ! distal phalanx of manual digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002519 @@ -121830,7 +221182,7 @@ synonym: "length of distal phalanx of manual digit 5" EXACT [AUTO:patterns/patte is_a: OBA:0002909 ! distal phalanx of manual digit 5 size is_a: OBA:0003016 ! distal phalanx of manus length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002520 @@ -121841,8 +221193,8 @@ is_a: OBA:0002207 ! skeletal joint displaced is_a: OBA:0002688 ! proximal interphalangeal joint position is_a: OBA:1000440 ! interphalangeal joint of manus quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0016426 ! proximal interphalangeal joint of little finger -relationship: inheres_in UBERON:0016426 ! proximal interphalangeal joint of little finger +intersection_of: RO:0000052 UBERON:0016426 ! inheres in proximal interphalangeal joint of little finger +relationship: RO:0000052 UBERON:0016426 ! inheres in proximal interphalangeal joint of little finger [Term] id: OBA:0002521 @@ -121852,8 +221204,8 @@ synonym: "amount of carpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001435 ! carpal bone -relationship: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone +relationship: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0002522 @@ -121863,8 +221215,8 @@ synonym: "mass density of carpal bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT0005007 ! bone mineral mass intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001435 ! carpal bone -relationship: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone +relationship: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0002523 @@ -121874,7 +221226,7 @@ synonym: "displaced of carpal bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002689 ! carpal bone position is_a: OBA:0004786 ! bone element displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0002524 @@ -121883,8 +221235,8 @@ def: "The amount of a radiale." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of radiale" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002521 ! carpal bone amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001427 ! radiale -relationship: inheres_in UBERON:0001427 ! radiale +intersection_of: RO:0000052 UBERON:0001427 ! inheres in radiale +relationship: RO:0000052 UBERON:0001427 ! inheres in radiale [Term] id: OBA:0002525 @@ -121894,7 +221246,7 @@ synonym: "size of radiale" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002213 ! carpal bone size is_a: OBA:0005190 ! radiale morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001427 ! radiale +intersection_of: RO:0000052 UBERON:0001427 ! inheres in radiale [Term] id: OBA:0002526 @@ -121903,8 +221255,8 @@ def: "The amount of a intermedium." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of intermedium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002521 ! carpal bone amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001428 ! intermedium -relationship: inheres_in UBERON:0001428 ! intermedium +intersection_of: RO:0000052 UBERON:0001428 ! inheres in intermedium +relationship: RO:0000052 UBERON:0001428 ! inheres in intermedium [Term] id: OBA:0002527 @@ -121913,8 +221265,8 @@ def: "The displaced of a intermedium." [AUTO:patterns/patterns/entity_attribute] synonym: "displaced of intermedium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002523 ! carpal bone displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001428 ! intermedium -relationship: inheres_in UBERON:0001428 ! intermedium +intersection_of: RO:0000052 UBERON:0001428 ! inheres in intermedium +relationship: RO:0000052 UBERON:0001428 ! inheres in intermedium [Term] id: OBA:0002528 @@ -121923,8 +221275,8 @@ def: "The size of a distal carpal bone 1." [AUTO:patterns/patterns/entity_attrib synonym: "size of distal carpal bone 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002213 ! carpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001430 ! distal carpal bone 1 -relationship: inheres_in UBERON:0001430 ! distal carpal bone 1 +intersection_of: RO:0000052 UBERON:0001430 ! inheres in distal carpal bone 1 +relationship: RO:0000052 UBERON:0001430 ! inheres in distal carpal bone 1 [Term] id: OBA:0002529 @@ -121933,8 +221285,8 @@ def: "The size of a distal carpal bone 2." [AUTO:patterns/patterns/entity_attrib synonym: "size of distal carpal bone 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002213 ! carpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001431 ! distal carpal bone 2 -relationship: inheres_in UBERON:0001431 ! distal carpal bone 2 +intersection_of: RO:0000052 UBERON:0001431 ! inheres in distal carpal bone 2 +relationship: RO:0000052 UBERON:0001431 ! inheres in distal carpal bone 2 [Term] id: OBA:0002530 @@ -121943,8 +221295,8 @@ def: "The size of a distal carpal bone 4." [AUTO:patterns/patterns/entity_attrib synonym: "size of distal carpal bone 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002213 ! carpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001433 ! distal carpal bone 4 -relationship: inheres_in UBERON:0001433 ! distal carpal bone 4 +intersection_of: RO:0000052 UBERON:0001433 ! inheres in distal carpal bone 4 +relationship: RO:0000052 UBERON:0001433 ! inheres in distal carpal bone 4 [Term] id: OBA:0002531 @@ -121953,8 +221305,8 @@ def: "The size of a distal carpal bone 3." [AUTO:patterns/patterns/entity_attrib synonym: "size of distal carpal bone 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002213 ! carpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001432 ! distal carpal bone 3 -relationship: inheres_in UBERON:0001432 ! distal carpal bone 3 +intersection_of: RO:0000052 UBERON:0001432 ! inheres in distal carpal bone 3 +relationship: RO:0000052 UBERON:0001432 ! inheres in distal carpal bone 3 [Term] id: OBA:0002532 @@ -121964,7 +221316,7 @@ synonym: "position of abdominal wall" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000561 ! abdominal wall quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0003697 ! abdominal wall +intersection_of: RO:0000052 UBERON:0003697 ! inheres in abdominal wall [Term] id: OBA:0002533 @@ -121973,8 +221325,8 @@ def: "The strength of a respiratory muscle." [AUTO:patterns/patterns/entity_attr synonym: "strength of respiratory muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000079 ! muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0014398 ! respiratory muscle -relationship: inheres_in UBERON:0014398 ! respiratory muscle +intersection_of: RO:0000052 UBERON:0014398 ! inheres in respiratory muscle +relationship: RO:0000052 UBERON:0014398 ! inheres in respiratory muscle [Term] id: OBA:0002534 @@ -121984,7 +221336,7 @@ synonym: "composition of aortic valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002238 ! aortic valve structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0002535 @@ -121994,7 +221346,7 @@ synonym: "composition of mitral valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002245 ! mitral valve structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0002536 @@ -122004,7 +221356,7 @@ synonym: "closure of pylorus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005198 ! pylorus morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001166 ! pylorus +intersection_of: RO:0000052 UBERON:0001166 ! inheres in pylorus [Term] id: OBA:0002537 @@ -122014,7 +221366,7 @@ synonym: "functionality of sensory perception of smell" EXACT [AUTO:patterns/pat is_a: OBA:VT0001984 ! olfaction trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0007608 ! sensory perception of smell +intersection_of: RO:0000052 GO:0007608 ! inheres in sensory perception of smell [Term] id: OBA:0002538 @@ -122024,7 +221376,7 @@ synonym: "sensitivity of a process of sensory perception of smell" EXACT [AUTO:p is_a: OBA:VT0001984 ! olfaction trait is_a: PATO:0001457 ! sensitivity of a process intersection_of: PATO:0001457 ! sensitivity of a process -intersection_of: inheres_in GO:0007608 ! sensory perception of smell +intersection_of: RO:0000052 GO:0007608 ! inheres in sensory perception of smell [Term] id: OBA:0002539 @@ -122034,7 +221386,7 @@ synonym: "structure of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003389 ! artery structure is_a: OBA:VT0000484 ! pulmonary artery morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:0002540 @@ -122044,7 +221396,7 @@ synonym: "curvature of forehead" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002071 ! forehead shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0008200 ! forehead +intersection_of: RO:0000052 UBERON:0008200 ! inheres in forehead [Term] id: OBA:0002541 @@ -122053,8 +221405,8 @@ def: "The size of a internal surface of frontal bone." [AUTO:patterns/patterns/e synonym: "size of internal surface of frontal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0017690 ! internal surface of frontal bone -relationship: inheres_in UBERON:0017690 ! internal surface of frontal bone +intersection_of: RO:0000052 UBERON:0017690 ! inheres in internal surface of frontal bone +relationship: RO:0000052 UBERON:0017690 ! inheres in internal surface of frontal bone [Term] id: OBA:0002542 @@ -122064,7 +221416,7 @@ synonym: "convex 3-D shape of erythrocyte" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002641 ! erythrocyte shape trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:0002543 @@ -122074,7 +221426,7 @@ synonym: "size of internal acoustic meatus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004286 ! internal auditory canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011859 ! internal acoustic meatus +intersection_of: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus [Term] id: OBA:0002544 @@ -122084,7 +221436,7 @@ synonym: "symmetry of facial skeleton" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0005274 ! viscerocranium morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0011156 ! facial skeleton +intersection_of: RO:0000052 UBERON:0011156 ! inheres in facial skeleton [Term] id: OBA:0002545 @@ -122093,8 +221445,8 @@ def: "The size of a posterior fontanelle." [AUTO:patterns/patterns/entity_attrib synonym: "size of posterior fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002048 ! fontanelle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006683 ! posterior fontanelle -relationship: inheres_in UBERON:0006683 ! posterior fontanelle +intersection_of: RO:0000052 UBERON:0006683 ! inheres in posterior fontanelle +relationship: RO:0000052 UBERON:0006683 ! inheres in posterior fontanelle [Term] id: OBA:0002546 @@ -122104,7 +221456,7 @@ synonym: "size of facial skeleton" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005274 ! viscerocranium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011156 ! facial skeleton +intersection_of: RO:0000052 UBERON:0011156 ! inheres in facial skeleton [Term] id: OBA:0002547 @@ -122114,7 +221466,7 @@ synonym: "closure of posterior nasal aperture" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002094 ! internal naris closure is_a: OBA:VT0002236 ! internal nares morphology trait intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0004771 ! posterior nasal aperture +intersection_of: RO:0000052 UBERON:0004771 ! inheres in posterior nasal aperture [Term] id: OBA:0002548 @@ -122124,7 +221476,7 @@ synonym: "size of islet of Langerhans" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005215 ! islet of Langerhans morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000006 ! islet of Langerhans +intersection_of: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans [Term] id: OBA:0002549 @@ -122134,7 +221486,7 @@ synonym: "length of eyebrow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002117 ! eyebrow size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0010163 ! eyebrow +intersection_of: RO:0000052 UBERON:0010163 ! inheres in eyebrow [Term] id: OBA:0002550 @@ -122144,8 +221496,8 @@ synonym: "mass density of vertebral column" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001130 ! vertebral column -relationship: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column +relationship: RO:0000052 UBERON:0001130 ! inheres in vertebral column [Term] id: OBA:0002551 @@ -122155,7 +221507,7 @@ synonym: "2-D shape of bony vertebral centrum" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0000141 ! vertebral body morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002552 @@ -122164,8 +221516,8 @@ def: "The structure of a cervical vertebral arch joint." [AUTO:patterns/patterns synonym: "structure of cervical vertebral arch joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003791 ! synovial joint structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0016404 ! cervical vertebral arch joint -relationship: inheres_in UBERON:0016404 ! cervical vertebral arch joint +intersection_of: RO:0000052 UBERON:0016404 ! inheres in cervical vertebral arch joint +relationship: RO:0000052 UBERON:0016404 ! inheres in cervical vertebral arch joint [Term] id: OBA:0002553 @@ -122175,7 +221527,7 @@ synonym: "spatial pattern of bony vertebral centrum" EXACT [AUTO:patterns/patter is_a: OBA:VT0000141 ! vertebral body morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002554 @@ -122185,7 +221537,7 @@ synonym: "concavity of bony vertebral centrum" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0000141 ! vertebral body morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002555 @@ -122195,8 +221547,8 @@ synonym: "structure of lumbar vertebra 2" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004028 ! vertebra structure is_a: OBA:VT0010494 ! lumbar vertebra morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004618 ! lumbar vertebra 2 -relationship: inheres_in UBERON:0004618 ! lumbar vertebra 2 +intersection_of: RO:0000052 UBERON:0004618 ! inheres in lumbar vertebra 2 +relationship: RO:0000052 UBERON:0004618 ! inheres in lumbar vertebra 2 [Term] id: OBA:0002556 @@ -122206,7 +221558,7 @@ synonym: "size of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004993 ! fused sacrum morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0002557 @@ -122216,7 +221568,7 @@ synonym: "curvature of thoracic vertebra" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0005332 ! vertebra curvature is_a: OBA:VT0003047 ! thoracic vertebra morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002347 ! thoracic vertebra +intersection_of: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra [Term] id: OBA:0002558 @@ -122226,7 +221578,7 @@ synonym: "displaced of odontoid process of cervical vertebra 2" EXACT [AUTO:patt is_a: OBA:1000235 ! odontoid process of cervical vertebra 2 quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0004096 ! odontoid process of cervical vertebra 2 +intersection_of: RO:0000052 UBERON:0004096 ! inheres in odontoid process of cervical vertebra 2 [Term] id: OBA:0002559 @@ -122236,8 +221588,8 @@ synonym: "structure of lumbar division of spinal cord central canal" EXACT [AUTO is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0014543 ! lumbar division of spinal cord central canal -relationship: inheres_in UBERON:0014543 ! lumbar division of spinal cord central canal +intersection_of: RO:0000052 UBERON:0014543 ! inheres in lumbar division of spinal cord central canal +relationship: RO:0000052 UBERON:0014543 ! inheres in lumbar division of spinal cord central canal [Term] id: OBA:0002560 @@ -122247,8 +221599,8 @@ synonym: "closure of bony part of vertebral arch of first sacral vertebra" EXACT is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0017671 ! bony part of vertebral arch of first sacral vertebra -relationship: inheres_in UBERON:0017671 ! bony part of vertebral arch of first sacral vertebra +intersection_of: RO:0000052 UBERON:0017671 ! inheres in bony part of vertebral arch of first sacral vertebra +relationship: RO:0000052 UBERON:0017671 ! inheres in bony part of vertebral arch of first sacral vertebra [Term] id: OBA:0002561 @@ -122258,8 +221610,8 @@ synonym: "shape of arch of centrum of vertebra" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0010358 ! arch of centrum of vertebra -relationship: inheres_in UBERON:0010358 ! arch of centrum of vertebra +intersection_of: RO:0000052 UBERON:0010358 ! inheres in arch of centrum of vertebra +relationship: RO:0000052 UBERON:0010358 ! inheres in arch of centrum of vertebra [Term] id: OBA:0002562 @@ -122269,7 +221621,7 @@ synonym: "size of pedicle of vertebra" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000140 ! pedicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001078 ! pedicle of vertebra +intersection_of: RO:0000052 UBERON:0001078 ! inheres in pedicle of vertebra [Term] id: OBA:0002563 @@ -122279,7 +221631,7 @@ synonym: "strength of frontalis muscle belly" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000475 ! frontalis muscle belly quality is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0010952 ! frontalis muscle belly +intersection_of: RO:0000052 UBERON:0010952 ! inheres in frontalis muscle belly [Term] id: OBA:0002564 @@ -122289,7 +221641,7 @@ synonym: "size of tarsal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002810 ! tarsal bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001447 ! tarsal bone +intersection_of: RO:0000052 UBERON:0001447 ! inheres in tarsal bone [Term] id: OBA:0002565 @@ -122299,7 +221651,7 @@ synonym: "length of metatarsal bone of digit 3" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004033 ! metatarsal bone length is_a: OBA:1000413 ! metatarsal bone of digit 3 quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003652 ! metatarsal bone of digit 3 +intersection_of: RO:0000052 UBERON:0003652 ! inheres in metatarsal bone of digit 3 [Term] id: OBA:0002566 @@ -122309,7 +221661,7 @@ synonym: "mass density of tarsal bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000508 ! tarsal bone quality is_a: OBA:VT0005007 ! bone mineral mass intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001447 ! tarsal bone +intersection_of: RO:0000052 UBERON:0001447 ! inheres in tarsal bone [Term] id: OBA:0002567 @@ -122319,7 +221671,7 @@ synonym: "length of metatarsal bone of digit 4" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004033 ! metatarsal bone length is_a: OBA:1000611 ! metatarsal bone of digit 4 quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003653 ! metatarsal bone of digit 4 +intersection_of: RO:0000052 UBERON:0003653 ! inheres in metatarsal bone of digit 4 [Term] id: OBA:0002568 @@ -122330,8 +221682,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005503 ! tendon morphology trait is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003701 ! calcaneal tendon -relationship: inheres_in UBERON:0003701 ! calcaneal tendon +intersection_of: RO:0000052 UBERON:0003701 ! inheres in calcaneal tendon +relationship: RO:0000052 UBERON:0003701 ! inheres in calcaneal tendon [Term] id: OBA:0002569 @@ -122341,7 +221693,7 @@ synonym: "length of metatarsal bone of digit 5" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004033 ! metatarsal bone length is_a: OBA:1000254 ! metatarsal bone of digit 5 quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003654 ! metatarsal bone of digit 5 +intersection_of: RO:0000052 UBERON:0003654 ! inheres in metatarsal bone of digit 5 [Term] id: OBA:0002570 @@ -122351,7 +221703,7 @@ synonym: "rotated of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002135 ! kidney morphology trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0002571 @@ -122361,7 +221713,7 @@ synonym: "rotated of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000495 ! colon morphology trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:0002572 @@ -122371,7 +221723,7 @@ synonym: "size of small intestine" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000496 ! small intestine morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:0002573 @@ -122381,7 +221733,7 @@ synonym: "rotated of small intestine" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000496 ! small intestine morphology trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:0002574 @@ -122390,8 +221742,8 @@ def: "The strength of a intercostal muscle." [AUTO:patterns/patterns/entity_attr synonym: "strength of intercostal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000079 ! muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001111 ! intercostal muscle -relationship: inheres_in UBERON:0001111 ! intercostal muscle +intersection_of: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle +relationship: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle [Term] id: OBA:0002575 @@ -122401,8 +221753,8 @@ synonym: "rate of galactose metabolic process" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000452 ! carbohydrate metabolic process quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006012 ! galactose metabolic process -relationship: inheres_in GO:0006012 ! galactose metabolic process +intersection_of: RO:0000052 GO:0006012 ! inheres in galactose metabolic process +relationship: RO:0000052 GO:0006012 ! inheres in galactose metabolic process [Term] id: OBA:0002576 @@ -122412,7 +221764,7 @@ synonym: "closure of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0004197 ! artery closure is_a: OBA:VT0000484 ! pulmonary artery morphology trait intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:0002577 @@ -122422,7 +221774,7 @@ synonym: "size of descending thoracic aorta" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004884 ! descending thoracic aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002345 ! descending thoracic aorta +intersection_of: RO:0000052 UBERON:0002345 ! inheres in descending thoracic aorta [Term] id: OBA:0002578 @@ -122432,8 +221784,8 @@ synonym: "amount of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery -relationship: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery +relationship: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:0002579 @@ -122443,7 +221795,7 @@ synonym: "composition of thoracic aorta" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0010567 ! thoracic aorta morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001515 ! thoracic aorta +intersection_of: RO:0000052 UBERON:0001515 ! inheres in thoracic aorta [Term] id: OBA:0002580 @@ -122453,7 +221805,7 @@ synonym: "composition of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002242 ! aorta structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:0002581 @@ -122463,7 +221815,7 @@ synonym: "size of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0000484 ! pulmonary artery morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:0002582 @@ -122473,7 +221825,7 @@ synonym: "structure of abdominal aorta" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004886 ! abdominal aorta morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001516 ! abdominal aorta +intersection_of: RO:0000052 UBERON:0001516 ! inheres in abdominal aorta [Term] id: OBA:0002583 @@ -122484,8 +221836,8 @@ is_a: OBA:0002207 ! skeletal joint displaced is_a: OBA:1000205 ! synovial joint quality is_a: OBA:1000341 ! hindlimb joint quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001485 ! knee joint -relationship: inheres_in UBERON:0001485 ! knee joint +intersection_of: RO:0000052 UBERON:0001485 ! inheres in knee joint +relationship: RO:0000052 UBERON:0001485 ! inheres in knee joint [Term] id: OBA:0002584 @@ -122495,7 +221847,7 @@ synonym: "position of styloid process of ulna" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000279 ! styloid process of ulna quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0011575 ! styloid process of ulna +intersection_of: RO:0000052 UBERON:0011575 ! inheres in styloid process of ulna [Term] id: OBA:0002585 @@ -122505,7 +221857,7 @@ synonym: "curvature of proximal epiphysis of radius" EXACT [AUTO:patterns/patter is_a: OBA:0002494 ! epiphysis of radius curvature is_a: OBA:1000304 ! proximal epiphysis of radius quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004413 ! proximal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004413 ! inheres in proximal epiphysis of radius [Term] id: OBA:0002586 @@ -122515,7 +221867,7 @@ synonym: "structure of distal epiphysis of radius" EXACT [AUTO:patterns/patterns is_a: OBA:0002344 ! epiphysis structure is_a: OBA:1000600 ! distal epiphysis of radius quality intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004407 ! distal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004407 ! inheres in distal epiphysis of radius [Term] id: OBA:0002587 @@ -122525,7 +221877,7 @@ synonym: "size of diaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004214 ! long bone diaphysis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004769 ! diaphysis +intersection_of: RO:0000052 UBERON:0004769 ! inheres in diaphysis [Term] id: OBA:0002588 @@ -122535,7 +221887,7 @@ synonym: "length of phalanx of pes" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:VT0002543 ! phalanx length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:0002589 @@ -122544,8 +221896,8 @@ def: "The mass density of a proximal epiphysis of femur." [AUTO:patterns/pattern synonym: "mass density of proximal epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002712 ! epiphysis of femur mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004412 ! proximal epiphysis of femur -relationship: inheres_in UBERON:0004412 ! proximal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur +relationship: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur [Term] id: OBA:0002590 @@ -122555,7 +221907,7 @@ synonym: "size of proximal epiphysis of fibula" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003163 ! epiphysis size is_a: OBA:1000560 ! proximal epiphysis of fibula quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008775 ! proximal epiphysis of fibula +intersection_of: RO:0000052 UBERON:0008775 ! inheres in proximal epiphysis of fibula [Term] id: OBA:0002591 @@ -122565,7 +221917,7 @@ synonym: "amount of styloid process of ulna" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000279 ! styloid process of ulna quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011575 ! styloid process of ulna +intersection_of: RO:0000052 UBERON:0011575 ! inheres in styloid process of ulna [Term] id: OBA:0002592 @@ -122575,7 +221927,7 @@ synonym: "amount of proximal epiphysis of radius" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003160 ! epiphysis amount is_a: OBA:1000304 ! proximal epiphysis of radius quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004413 ! proximal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004413 ! inheres in proximal epiphysis of radius [Term] id: OBA:0002593 @@ -122585,7 +221937,7 @@ synonym: "degeneration of cochlea" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000031 ! cochlea morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:0002594 @@ -122595,7 +221947,7 @@ synonym: "composition of cartilage of external ear" EXACT [AUTO:patterns/pattern is_a: OBA:0003391 ! cartilage element composition is_a: OBA:VT0003737 ! outer ear cartilage morphology trait intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001867 ! cartilage of external ear +intersection_of: RO:0000052 UBERON:0001867 ! inheres in cartilage of external ear [Term] id: OBA:0002595 @@ -122605,7 +221957,7 @@ synonym: "size of nasal septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002239 ! nasal septum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001706 ! nasal septum +intersection_of: RO:0000052 UBERON:0001706 ! inheres in nasal septum [Term] id: OBA:0002596 @@ -122615,7 +221967,7 @@ synonym: "size of ascending aorta" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004883 ! ascending aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001496 ! ascending aorta +intersection_of: RO:0000052 UBERON:0001496 ! inheres in ascending aorta [Term] id: OBA:0002597 @@ -122625,7 +221977,7 @@ synonym: "size of abdominal aorta" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004886 ! abdominal aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001516 ! abdominal aorta +intersection_of: RO:0000052 UBERON:0001516 ! inheres in abdominal aorta [Term] id: OBA:0002598 @@ -122635,7 +221987,7 @@ synonym: "size of arch of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003913 ! arch of aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:0002599 @@ -122645,8 +221997,8 @@ synonym: "amount of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve -relationship: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve +relationship: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0002600 @@ -122657,7 +222009,7 @@ is_a: OBA:0003389 ! artery structure is_a: OBA:0004973 ! heart blood vessel structure is_a: OBA:VT0004111 ! coronary artery morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001621 ! coronary artery +intersection_of: RO:0000052 UBERON:0001621 ! inheres in coronary artery [Term] id: OBA:0002601 @@ -122666,8 +222018,8 @@ def: "The sufficiency of a tricuspid valve." [AUTO:patterns/patterns/entity_attr synonym: "sufficiency of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004175 ! atrioventricular valve sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve -relationship: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve +relationship: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0002602 @@ -122678,7 +222030,7 @@ is_a: OBA:VT0000044 ! pulmonary valve morphology trait is_a: OBA:VT0000285 ! heart valve morphology trait is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0002603 @@ -122688,7 +222040,7 @@ synonym: "size of synovial joint" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002383 ! skeletal joint size is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002217 ! synovial joint +intersection_of: RO:0000052 UBERON:0002217 ! inheres in synovial joint [Term] id: OBA:0002604 @@ -122698,7 +222050,7 @@ synonym: "flexibility of interphalangeal joint" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000139 ! skeletal joint flexibility is_a: OBA:1000699 ! interphalangeal joint quality intersection_of: PATO:0001543 ! flexibility -intersection_of: inheres_in UBERON:0006658 ! interphalangeal joint +intersection_of: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint [Term] id: OBA:0002605 @@ -122708,7 +222060,7 @@ synonym: "amount of abdomen musculature" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000614 ! abdomen musculature quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002343 ! abdomen musculature +intersection_of: RO:0000052 UBERON:0002343 ! inheres in abdomen musculature [Term] id: OBA:0002606 @@ -122718,7 +222070,7 @@ synonym: "structure of intrahepatic bile duct" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0004745 ! intrahepatic bile duct morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003704 ! intrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct [Term] id: OBA:0002607 @@ -122728,7 +222080,7 @@ synonym: "rotated of midgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004828 ! midgut morphology is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001045 ! midgut +intersection_of: RO:0000052 UBERON:0001045 ! inheres in midgut [Term] id: OBA:0002608 @@ -122738,7 +222090,7 @@ synonym: "composition of pancreas" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002612 ! pancreas structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:0002609 @@ -122748,7 +222100,7 @@ synonym: "closure of intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000477 ! intestine morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0002610 @@ -122758,7 +222110,7 @@ synonym: "composition of intestine" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005591 ! intestine structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0002611 @@ -122768,7 +222120,7 @@ synonym: "closure of biliary tree" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0005083 ! biliary tract morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001173 ! biliary tree +intersection_of: RO:0000052 UBERON:0001173 ! inheres in biliary tree [Term] id: OBA:0002612 @@ -122778,7 +222130,7 @@ synonym: "structure of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001944 ! pancreas morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:0002613 @@ -122788,7 +222140,7 @@ synonym: "closure of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004002 ! jejunum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002115 ! jejunum +intersection_of: RO:0000052 UBERON:0002115 ! inheres in jejunum [Term] id: OBA:0002614 @@ -122798,7 +222150,7 @@ synonym: "degeneration of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000598 ! liver morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:0002615 @@ -122808,7 +222160,7 @@ synonym: "closure of extrahepatic bile duct" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0004746 ! extrahepatic bile duct morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003703 ! inheres in extrahepatic bile duct [Term] id: OBA:0002616 @@ -122818,7 +222170,7 @@ synonym: "size of intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000477 ! intestine morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0002617 @@ -122828,7 +222180,7 @@ synonym: "size of muscle of abdomen" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002879 ! muscle organ size is_a: OBA:0005974 ! muscle of abdomen morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002378 ! muscle of abdomen +intersection_of: RO:0000052 UBERON:0002378 ! inheres in muscle of abdomen [Term] id: OBA:0002618 @@ -122838,7 +222190,7 @@ synonym: "closure of intrahepatic bile duct" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0004745 ! intrahepatic bile duct morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003704 ! intrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct [Term] id: OBA:0002619 @@ -122848,8 +222200,8 @@ synonym: "amount of pectoralis minor" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001100 ! pectoralis minor -relationship: inheres_in UBERON:0001100 ! pectoralis minor +intersection_of: RO:0000052 UBERON:0001100 ! inheres in pectoralis minor +relationship: RO:0000052 UBERON:0001100 ! inheres in pectoralis minor [Term] id: OBA:0002620 @@ -122859,7 +222211,7 @@ synonym: "size of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003917 ! chest morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:0002621 @@ -122869,7 +222221,7 @@ synonym: "amount of cartilage of nasal septum" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000379 ! cartilage of nasal septum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003407 ! cartilage of nasal septum +intersection_of: RO:0000052 UBERON:0003407 ! inheres in cartilage of nasal septum [Term] id: OBA:0002622 @@ -122879,8 +222231,8 @@ synonym: "position of nose tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0012128 ! nose tip -relationship: inheres_in UBERON:0012128 ! nose tip +intersection_of: RO:0000052 UBERON:0012128 ! inheres in nose tip +relationship: RO:0000052 UBERON:0012128 ! inheres in nose tip [Term] id: OBA:0002623 @@ -122890,8 +222242,8 @@ synonym: "curvature of nasal bridge" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0008340 ! nasal bridge -relationship: inheres_in UBERON:0008340 ! nasal bridge +intersection_of: RO:0000052 UBERON:0008340 ! inheres in nasal bridge +relationship: RO:0000052 UBERON:0008340 ! inheres in nasal bridge [Term] id: OBA:0002624 @@ -122901,8 +222253,8 @@ synonym: "amount of nasal bridge" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008340 ! nasal bridge -relationship: inheres_in UBERON:0008340 ! nasal bridge +intersection_of: RO:0000052 UBERON:0008340 ! inheres in nasal bridge +relationship: RO:0000052 UBERON:0008340 ! inheres in nasal bridge [Term] id: OBA:0002625 @@ -122912,7 +222264,7 @@ synonym: "size of internal carotid artery" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000032 ! blood vessel size is_a: OBA:0005713 ! internal carotid artery morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001532 ! internal carotid artery +intersection_of: RO:0000052 UBERON:0001532 ! inheres in internal carotid artery [Term] id: OBA:0002626 @@ -122923,7 +222275,7 @@ is_a: OBA:1000292 ! vein quality is_a: OBA:VT0000170 ! blood vessel physiology trait is_a: PATO:0001626 ! sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0001638 ! vein +intersection_of: RO:0000052 UBERON:0001638 ! inheres in vein [Term] id: OBA:0002627 @@ -122933,7 +222285,7 @@ synonym: "composition of arch of aorta" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0002579 ! thoracic aorta composition is_a: OBA:0003913 ! arch of aorta morphology intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:0002628 @@ -122943,7 +222295,7 @@ synonym: "size of pulmonary vein" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0002726 ! pulmonary vein morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002016 ! pulmonary vein +intersection_of: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein [Term] id: OBA:0002629 @@ -122953,8 +222305,8 @@ synonym: "amount of lung vasculature" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000102 ! lung vasculature -relationship: inheres_in UBERON:0000102 ! lung vasculature +intersection_of: RO:0000052 UBERON:0000102 ! inheres in lung vasculature +relationship: RO:0000052 UBERON:0000102 ! inheres in lung vasculature [Term] id: OBA:0002630 @@ -122964,8 +222316,8 @@ synonym: "position of nasal septum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001706 ! nasal septum -relationship: inheres_in UBERON:0001706 ! nasal septum +intersection_of: RO:0000052 UBERON:0001706 ! inheres in nasal septum +relationship: RO:0000052 UBERON:0001706 ! inheres in nasal septum [Term] id: OBA:0002631 @@ -122975,7 +222327,7 @@ synonym: "size of epiglottis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002259 ! epiglottis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000388 ! epiglottis +intersection_of: RO:0000052 UBERON:0000388 ! inheres in epiglottis [Term] id: OBA:0002632 @@ -122985,7 +222337,7 @@ synonym: "functionality of B cell differentiation" EXACT [AUTO:patterns/patterns is_a: OBA:0002634 ! B cell activation functionality is_a: OBA:VT0002144 ! B cell development trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0030183 ! B cell differentiation +intersection_of: RO:0000052 GO:0030183 ! inheres in B cell differentiation [Term] id: OBA:0002633 @@ -122995,7 +222347,7 @@ synonym: "amount of B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003352 ! lymphocyte amount is_a: OBA:1000574 ! B cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000236 ! B cell +intersection_of: RO:0000052 CL:0000236 ! inheres in B cell [Term] id: OBA:0002634 @@ -123005,8 +222357,8 @@ synonym: "functionality of B cell activation" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0042113 ! B cell activation -relationship: inheres_in GO:0042113 ! B cell activation +intersection_of: RO:0000052 GO:0042113 ! inheres in B cell activation +relationship: RO:0000052 GO:0042113 ! inheres in B cell activation [Term] id: OBA:0002635 @@ -123017,8 +222369,8 @@ is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:1000866 ! blood cell quality is_a: PATO:0001488 ! cellular motility intersection_of: PATO:0001488 ! cellular motility -intersection_of: inheres_in CL:0000775 ! neutrophil -relationship: inheres_in CL:0000775 ! neutrophil +intersection_of: RO:0000052 CL:0000775 ! inheres in neutrophil +relationship: RO:0000052 CL:0000775 ! inheres in neutrophil [Term] id: OBA:0002636 @@ -123028,7 +222380,7 @@ synonym: "amount of T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003352 ! lymphocyte amount is_a: OBA:1000418 ! T cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000084 ! T cell +intersection_of: RO:0000052 CL:0000084 ! inheres in T cell [Term] id: OBA:0002637 @@ -123037,8 +222389,8 @@ def: "The amount of a CD4-positive helper T cell." [AUTO:patterns/patterns/entit synonym: "amount of CD4-positive helper T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004294 ! CD4-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000492 ! CD4-positive helper T cell -relationship: inheres_in CL:0000492 ! CD4-positive helper T cell +intersection_of: RO:0000052 CL:0000492 ! inheres in CD4-positive helper T cell +relationship: RO:0000052 CL:0000492 ! inheres in CD4-positive helper T cell [Term] id: OBA:0002638 @@ -123048,8 +222400,8 @@ synonym: "amount of CD8-positive, alpha-beta regulatory T cell" EXACT [AUTO:patt is_a: OBA:0004108 ! regulatory T cell amount is_a: OBA:0004295 ! CD8-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000795 ! CD8-positive, alpha-beta regulatory T cell -relationship: inheres_in CL:0000795 ! CD8-positive, alpha-beta regulatory T cell +intersection_of: RO:0000052 CL:0000795 ! inheres in CD8-positive, alpha-beta regulatory T cell +relationship: RO:0000052 CL:0000795 ! inheres in CD8-positive, alpha-beta regulatory T cell [Term] id: OBA:0002639 @@ -123059,7 +222411,7 @@ synonym: "closure of coronal suture" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0003840 ! coronal suture morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002489 ! coronal suture +intersection_of: RO:0000052 UBERON:0002489 ! inheres in coronal suture [Term] id: OBA:0002640 @@ -123069,7 +222421,7 @@ synonym: "size of posterior cranial fossa" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002203 ! posterior cranial fossa morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008788 ! posterior cranial fossa +intersection_of: RO:0000052 UBERON:0008788 ! inheres in posterior cranial fossa [Term] id: OBA:0002641 @@ -123079,7 +222431,7 @@ synonym: "amount of ethmoid sinus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002349 ! paranasal sinus amount is_a: OBA:1000512 ! ethmoid sinus quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002453 ! ethmoid sinus +intersection_of: RO:0000052 UBERON:0002453 ! inheres in ethmoid sinus [Term] id: OBA:0002642 @@ -123089,7 +222441,7 @@ synonym: "composition of falx cerebri" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000224 ! falx cerebri quality is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0006059 ! falx cerebri +intersection_of: RO:0000052 UBERON:0006059 ! inheres in falx cerebri [Term] id: OBA:0002643 @@ -123099,7 +222451,7 @@ synonym: "size of tetrapod frontal bone" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000107 ! frontal bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000209 ! tetrapod frontal bone +intersection_of: RO:0000052 UBERON:0000209 ! inheres in tetrapod frontal bone [Term] id: OBA:0002644 @@ -123109,7 +222461,7 @@ synonym: "curvature of occipital bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003221 ! occipital bone shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:0002645 @@ -123119,7 +222471,7 @@ synonym: "closure of sagittal suture" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003843 ! sagittal suture morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002492 ! sagittal suture +intersection_of: RO:0000052 UBERON:0002492 ! inheres in sagittal suture [Term] id: OBA:0002646 @@ -123129,8 +222481,8 @@ synonym: "position of frontal suture" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000211 ! cranial suture quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002490 ! frontal suture -relationship: inheres_in UBERON:0002490 ! frontal suture +intersection_of: RO:0000052 UBERON:0002490 ! inheres in frontal suture +relationship: RO:0000052 UBERON:0002490 ! inheres in frontal suture [Term] id: OBA:0002647 @@ -123139,8 +222491,8 @@ def: "The onset quality of a posterior fontanelle." [AUTO:patterns/patterns/enti synonym: "onset quality of posterior fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002053 ! fontanelle onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0006683 ! posterior fontanelle -relationship: inheres_in UBERON:0006683 ! posterior fontanelle +intersection_of: RO:0000052 UBERON:0006683 ! inheres in posterior fontanelle +relationship: RO:0000052 UBERON:0006683 ! inheres in posterior fontanelle [Term] id: OBA:0002648 @@ -123150,8 +222502,8 @@ synonym: "amount of megakaryocyte" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003458 ! bone marrow cell amount is_a: OBA:0005899 ! myeloid cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000556 ! megakaryocyte -relationship: inheres_in CL:0000556 ! megakaryocyte +intersection_of: RO:0000052 CL:0000556 ! inheres in megakaryocyte +relationship: RO:0000052 CL:0000556 ! inheres in megakaryocyte [Term] id: OBA:0002649 @@ -123161,8 +222513,8 @@ synonym: "amount of renal glomerulus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000074 ! renal glomerulus -relationship: inheres_in UBERON:0000074 ! renal glomerulus +intersection_of: RO:0000052 UBERON:0000074 ! inheres in renal glomerulus +relationship: RO:0000052 UBERON:0000074 ! inheres in renal glomerulus [Term] id: OBA:0002650 @@ -123172,7 +222524,7 @@ synonym: "mobility of interphalangeal joint" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002208 ! skeletal joint mobility is_a: OBA:1000699 ! interphalangeal joint quality intersection_of: PATO:0000004 ! mobility -intersection_of: inheres_in UBERON:0006658 ! interphalangeal joint +intersection_of: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint [Term] id: OBA:0002651 @@ -123182,7 +222534,7 @@ synonym: "size of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0003723 ! long bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:0002652 @@ -123192,8 +222544,8 @@ synonym: "amount of forelimb zeugopod" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002386 ! forelimb zeugopod -relationship: inheres_in UBERON:0002386 ! forelimb zeugopod +intersection_of: RO:0000052 UBERON:0002386 ! inheres in forelimb zeugopod +relationship: RO:0000052 UBERON:0002386 ! inheres in forelimb zeugopod [Term] id: OBA:0002653 @@ -123203,7 +222555,7 @@ synonym: "length of pedal digit 3" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002261 ! pedal digit length is_a: OBA:0003359 ! pedal digit 3 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003633 ! pedal digit 3 +intersection_of: RO:0000052 UBERON:0003633 ! inheres in pedal digit 3 [Term] id: OBA:0002654 @@ -123213,7 +222565,7 @@ synonym: "composition of intervertebral disk" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003391 ! cartilage element composition is_a: OBA:VT0004173 ! intervertebral disk morphology trait intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:0002655 @@ -123223,8 +222575,8 @@ synonym: "morphology of proximal head of humerus" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006801 ! proximal head of humerus -relationship: inheres_in UBERON:0006801 ! proximal head of humerus +intersection_of: RO:0000052 UBERON:0006801 ! inheres in proximal head of humerus +relationship: RO:0000052 UBERON:0006801 ! inheres in proximal head of humerus [Term] id: OBA:0002656 @@ -123236,7 +222588,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0002175 ! deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002657 @@ -123246,7 +222598,7 @@ synonym: "size of forelimb zeugopod bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002478 ! forelimb zeugopod bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0002658 @@ -123256,7 +222608,7 @@ synonym: "curvature of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0005332 ! vertebra curvature is_a: OBA:VT0010494 ! lumbar vertebra morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:0002659 @@ -123266,7 +222618,7 @@ synonym: "size of mandible condylar process" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004022 ! mandible condylar process morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004657 ! mandible condylar process +intersection_of: RO:0000052 UBERON:0004657 ! inheres in mandible condylar process [Term] id: OBA:0002660 @@ -123276,7 +222628,7 @@ synonym: "amount of distal phalanx of manus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000190 ! distal phalanx of manus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0002661 @@ -123286,7 +222638,7 @@ synonym: "length of middle phalanx of manus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002683 ! phalanx of manus length is_a: OBA:0003009 ! middle phalanx of manus size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0002662 @@ -123296,7 +222648,7 @@ synonym: "deviation of pedal digit 2" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002268 ! pedal digit deviation is_a: OBA:1000191 ! pedal digit 2 quality intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003632 ! pedal digit 2 +intersection_of: RO:0000052 UBERON:0003632 ! inheres in pedal digit 2 [Term] id: OBA:0002663 @@ -123306,8 +222658,8 @@ synonym: "occurrence of bone maturation" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0070977 ! bone maturation -relationship: inheres_in GO:0070977 ! bone maturation +intersection_of: RO:0000052 GO:0070977 ! inheres in bone maturation +relationship: RO:0000052 GO:0070977 ! inheres in bone maturation [Term] id: OBA:0002664 @@ -123317,7 +222669,7 @@ synonym: "2-D shape of middle phalanx of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003002 ! phalanx of manus 2-D shape is_a: OBA:0003299 ! middle phalanx of manus shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0002665 @@ -123327,8 +222679,8 @@ synonym: "concavity of distal phalanx of manual digit 1" EXACT [AUTO:patterns/pa is_a: OBA:0003032 ! manual digit 1 phalanx concavity is_a: OBA:0003300 ! distal phalanx of manus shape intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002666 @@ -123338,8 +222690,8 @@ synonym: "closure of bony part of cervical vertebral arch" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0017670 ! bony part of cervical vertebral arch -relationship: inheres_in UBERON:0017670 ! bony part of cervical vertebral arch +intersection_of: RO:0000052 UBERON:0017670 ! inheres in bony part of cervical vertebral arch +relationship: RO:0000052 UBERON:0017670 ! inheres in bony part of cervical vertebral arch [Term] id: OBA:0002667 @@ -123348,8 +222700,8 @@ def: "The size of a internal surface of cranial base." [AUTO:patterns/patterns/e synonym: "size of internal surface of cranial base" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0017692 ! internal surface of cranial base -relationship: inheres_in UBERON:0017692 ! internal surface of cranial base +intersection_of: RO:0000052 UBERON:0017692 ! inheres in internal surface of cranial base +relationship: RO:0000052 UBERON:0017692 ! inheres in internal surface of cranial base [Term] id: OBA:0002668 @@ -123361,8 +222713,8 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0002175 ! deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002669 @@ -123372,8 +222724,8 @@ synonym: "amount of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone -relationship: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone +relationship: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002670 @@ -123383,8 +222735,8 @@ synonym: "growth quality of occurrent of cilium" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0001433 ! growth quality of occurrent intersection_of: PATO:0001433 ! growth quality of occurrent -intersection_of: inheres_in GO:0005929 ! cilium -relationship: inheres_in GO:0005929 ! cilium +intersection_of: RO:0000052 GO:0005929 ! inheres in cilium +relationship: RO:0000052 GO:0005929 ! inheres in cilium [Term] id: OBA:0002671 @@ -123394,7 +222746,7 @@ synonym: "closure of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002249 ! larynx morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:0002672 @@ -123404,7 +222756,7 @@ synonym: "rate of gluconeogenesis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0003383 ! gluconeogenesis trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006094 ! gluconeogenesis +intersection_of: RO:0000052 GO:0006094 ! inheres in gluconeogenesis [Term] id: OBA:0002673 @@ -123414,7 +222766,7 @@ synonym: "closure of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000534 ! ureter morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0002674 @@ -123424,7 +222776,7 @@ synonym: "size of phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0005306 ! phalanx morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003221 ! phalanx +intersection_of: RO:0000052 UBERON:0003221 ! inheres in phalanx [Term] id: OBA:0002675 @@ -123434,7 +222786,7 @@ synonym: "2-D shape of epiphysis of phalanx of manus" EXACT [AUTO:patterns/patte is_a: OBA:0003091 ! epiphysis of phalanx of manus shape is_a: OBA:0003165 ! epiphysis 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0002676 @@ -123443,8 +222795,8 @@ def: "The length of a metacarpal bone of digit 2." [AUTO:patterns/patterns/entit synonym: "length of metacarpal bone of digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003047 ! metacarpal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003646 ! metacarpal bone of digit 2 -relationship: inheres_in UBERON:0003646 ! metacarpal bone of digit 2 +intersection_of: RO:0000052 UBERON:0003646 ! inheres in metacarpal bone of digit 2 +relationship: RO:0000052 UBERON:0003646 ! inheres in metacarpal bone of digit 2 [Term] id: OBA:0002677 @@ -123454,7 +222806,7 @@ synonym: "branchiness of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002694 ! metacarpal bone shape is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002678 @@ -123463,8 +222815,8 @@ def: "The size of a distal epiphysis of metacarpal bone." [AUTO:patterns/pattern synonym: "size of distal epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002682 ! epiphysis of metacarpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013753 ! distal epiphysis of metacarpal bone -relationship: inheres_in UBERON:0013753 ! distal epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0013753 ! inheres in distal epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0013753 ! inheres in distal epiphysis of metacarpal bone [Term] id: OBA:0002679 @@ -123473,8 +222825,8 @@ def: "The convex 3-D shape of a epiphysis of metacarpal bone." [AUTO:patterns/pa synonym: "convex 3-D shape of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003162 ! epiphysis convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002680 @@ -123484,7 +222836,7 @@ synonym: "sharpness of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0002694 ! metacarpal bone shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002681 @@ -123494,7 +222846,7 @@ synonym: "length of proximal phalanx of manus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002683 ! phalanx of manus length is_a: OBA:0003012 ! proximal phalanx of manus size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:0002682 @@ -123503,8 +222855,8 @@ def: "The size of a epiphysis of metacarpal bone." [AUTO:patterns/patterns/entit synonym: "size of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003163 ! epiphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002683 @@ -123514,7 +222866,7 @@ synonym: "length of phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002999 ! phalanx of manus size is_a: OBA:VT0002543 ! phalanx length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0002684 @@ -123524,7 +222876,7 @@ synonym: "deviation of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002513 ! manual digit deviation is_a: OBA:0005188 ! manual digit 1 morphology intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0002685 @@ -123534,7 +222886,7 @@ synonym: "position of palmar skin crease" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000347 ! palmar skin crease quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0019246 ! palmar skin crease +intersection_of: RO:0000052 UBERON:0019246 ! inheres in palmar skin crease [Term] id: OBA:0002686 @@ -123544,7 +222896,7 @@ synonym: "size of metacarpophalangeal joint" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002603 ! synovial joint size is_a: OBA:1000216 ! metacarpophalangeal joint quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003695 ! metacarpophalangeal joint +intersection_of: RO:0000052 UBERON:0003695 ! inheres in metacarpophalangeal joint [Term] id: OBA:0002687 @@ -123554,7 +222906,7 @@ synonym: "convex 3-D shape of metacarpal bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002694 ! metacarpal bone shape is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002688 @@ -123563,8 +222915,8 @@ def: "The position of a proximal interphalangeal joint." [AUTO:patterns/patterns synonym: "position of proximal interphalangeal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002695 ! interphalangeal joint position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0009767 ! proximal interphalangeal joint -relationship: inheres_in UBERON:0009767 ! proximal interphalangeal joint +intersection_of: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint +relationship: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint [Term] id: OBA:0002689 @@ -123574,8 +222926,8 @@ synonym: "position of carpal bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001435 ! carpal bone -relationship: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone +relationship: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0002690 @@ -123586,7 +222938,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000347 ! palmar skin crease quality is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0019246 ! palmar skin crease +intersection_of: RO:0000052 UBERON:0019246 ! inheres in palmar skin crease [Term] id: OBA:0002691 @@ -123595,8 +222947,8 @@ def: "The size of a proximal interphalangeal joint." [AUTO:patterns/patterns/ent synonym: "size of proximal interphalangeal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002696 ! interphalangeal joint size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009767 ! proximal interphalangeal joint -relationship: inheres_in UBERON:0009767 ! proximal interphalangeal joint +intersection_of: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint +relationship: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint [Term] id: OBA:0002692 @@ -123609,7 +222961,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0002693 @@ -123618,8 +222970,8 @@ def: "The mobility of a distal interphalangeal joint." [AUTO:patterns/patterns/e synonym: "mobility of distal interphalangeal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002650 ! interphalangeal joint mobility intersection_of: PATO:0000004 ! mobility -intersection_of: inheres_in UBERON:0009768 ! distal interphalangeal joint -relationship: inheres_in UBERON:0009768 ! distal interphalangeal joint +intersection_of: RO:0000052 UBERON:0009768 ! inheres in distal interphalangeal joint +relationship: RO:0000052 UBERON:0009768 ! inheres in distal interphalangeal joint [Term] id: OBA:0002694 @@ -123629,7 +222981,7 @@ synonym: "shape of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003763 ! metacarpal bone morphology is_a: OBA:0005469 ! limb long bone shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0002695 @@ -123639,7 +222991,7 @@ synonym: "position of interphalangeal joint" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000699 ! interphalangeal joint quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0006658 ! interphalangeal joint +intersection_of: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint [Term] id: OBA:0002696 @@ -123649,7 +223001,7 @@ synonym: "size of interphalangeal joint" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0002603 ! synovial joint size is_a: OBA:1000699 ! interphalangeal joint quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006658 ! interphalangeal joint +intersection_of: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint [Term] id: OBA:0002697 @@ -123659,8 +223011,8 @@ synonym: "structure of proximal interphalangeal joint" EXACT [AUTO:patterns/patt is_a: OBA:0003791 ! synovial joint structure is_a: OBA:1000699 ! interphalangeal joint quality intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0009767 ! proximal interphalangeal joint -relationship: inheres_in UBERON:0009767 ! proximal interphalangeal joint +intersection_of: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint +relationship: RO:0000052 UBERON:0009767 ! inheres in proximal interphalangeal joint [Term] id: OBA:0002698 @@ -123670,8 +223022,8 @@ synonym: "amount of type B pancreatic cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000169 ! type B pancreatic cell -relationship: inheres_in CL:0000169 ! type B pancreatic cell +intersection_of: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell +relationship: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell [Term] id: OBA:0002699 @@ -123681,8 +223033,8 @@ synonym: "rate of enamel mineralization" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0002817 ! tooth mineralization trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070166 ! enamel mineralization -relationship: inheres_in GO:0070166 ! enamel mineralization +intersection_of: RO:0000052 GO:0070166 ! inheres in enamel mineralization +relationship: RO:0000052 GO:0070166 ! inheres in enamel mineralization [Term] id: OBA:0002700 @@ -123691,8 +223043,8 @@ def: "The amount of a central incisor tooth." [AUTO:patterns/patterns/entity_att synonym: "amount of central incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002731 ! incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018551 ! central incisor tooth -relationship: inheres_in UBERON:0018551 ! central incisor tooth +intersection_of: RO:0000052 UBERON:0018551 ! inheres in central incisor tooth +relationship: RO:0000052 UBERON:0018551 ! inheres in central incisor tooth [Term] id: OBA:0002701 @@ -123702,8 +223054,8 @@ synonym: "amount of upper central incisor tooth" EXACT [AUTO:patterns/patterns/e is_a: OBA:0002700 ! central incisor tooth amount is_a: OBA:0003424 ! upper jaw incisor amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018603 ! upper central incisor tooth -relationship: inheres_in UBERON:0018603 ! upper central incisor tooth +intersection_of: RO:0000052 UBERON:0018603 ! inheres in upper central incisor tooth +relationship: RO:0000052 UBERON:0018603 ! inheres in upper central incisor tooth [Term] id: OBA:0002702 @@ -123713,7 +223065,7 @@ synonym: "size of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002576 ! enamel morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:0002703 @@ -123722,8 +223074,8 @@ def: "The size of a primary dentition." [AUTO:patterns/patterns/entity_attribute synonym: "size of primary dentition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002134 ! dentition size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007116 ! primary dentition -relationship: inheres_in UBERON:0007116 ! primary dentition +intersection_of: RO:0000052 UBERON:0007116 ! inheres in primary dentition +relationship: RO:0000052 UBERON:0007116 ! inheres in primary dentition [Term] id: OBA:0002704 @@ -123733,8 +223085,8 @@ synonym: "persistence of primary dentition" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000082 ! persistence intersection_of: PATO:0000082 ! persistence -intersection_of: inheres_in UBERON:0007116 ! primary dentition -relationship: inheres_in UBERON:0007116 ! primary dentition +intersection_of: RO:0000052 UBERON:0007116 ! inheres in primary dentition +relationship: RO:0000052 UBERON:0007116 ! inheres in primary dentition [Term] id: OBA:0002705 @@ -123745,7 +223097,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000486 ! tooth root quality is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003677 ! tooth root +intersection_of: RO:0000052 UBERON:0003677 ! inheres in tooth root [Term] id: OBA:0002706 @@ -123754,8 +223106,8 @@ def: "The morphology of a lower secondary premolar tooth." [AUTO:patterns/patter synonym: "morphology of lower secondary premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003215 ! premolar tooth morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0016453 ! lower secondary premolar tooth -relationship: inheres_in UBERON:0016453 ! lower secondary premolar tooth +intersection_of: RO:0000052 UBERON:0016453 ! inheres in lower secondary premolar tooth +relationship: RO:0000052 UBERON:0016453 ! inheres in lower secondary premolar tooth [Term] id: OBA:0002707 @@ -123764,8 +223116,8 @@ def: "The convex 3-D shape of a lower jaw incisor." [AUTO:patterns/patterns/enti synonym: "convex 3-D shape of lower jaw incisor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003211 ! incisor tooth convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003451 ! lower jaw incisor -relationship: inheres_in UBERON:0003451 ! lower jaw incisor +intersection_of: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor +relationship: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor [Term] id: OBA:0002708 @@ -123774,8 +223126,8 @@ def: "The morphology of a primary molar tooth." [AUTO:patterns/patterns/entity_a synonym: "morphology of primary molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002689 ! molar morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013616 ! primary molar tooth -relationship: inheres_in UBERON:0013616 ! primary molar tooth +intersection_of: RO:0000052 UBERON:0013616 ! inheres in primary molar tooth +relationship: RO:0000052 UBERON:0013616 ! inheres in primary molar tooth [Term] id: OBA:0002709 @@ -123785,7 +223137,7 @@ synonym: "2-D shape of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005358 ! incisor morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0002710 @@ -123795,7 +223147,7 @@ synonym: "size of premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003215 ! premolar tooth morphology is_a: OBA:1000112 ! tooth size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007120 ! premolar tooth +intersection_of: RO:0000052 UBERON:0007120 ! inheres in premolar tooth [Term] id: OBA:0002711 @@ -123805,8 +223157,8 @@ synonym: "amount of lower central incisor tooth" EXACT [AUTO:patterns/patterns/e is_a: OBA:0002700 ! central incisor tooth amount is_a: OBA:0003425 ! lower jaw incisor amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018601 ! lower central incisor tooth -relationship: inheres_in UBERON:0018601 ! lower central incisor tooth +intersection_of: RO:0000052 UBERON:0018601 ! inheres in lower central incisor tooth +relationship: RO:0000052 UBERON:0018601 ! inheres in lower central incisor tooth [Term] id: OBA:0002712 @@ -123815,8 +223167,8 @@ def: "The mass density of a epiphysis of femur." [AUTO:patterns/patterns/entity_ synonym: "mass density of epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003164 ! epiphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004384 ! epiphysis of femur -relationship: inheres_in UBERON:0004384 ! epiphysis of femur +intersection_of: RO:0000052 UBERON:0004384 ! inheres in epiphysis of femur +relationship: RO:0000052 UBERON:0004384 ! inheres in epiphysis of femur [Term] id: OBA:0002713 @@ -123826,7 +223178,7 @@ synonym: "spatial pattern of patella" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005353 ! patella morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:0002714 @@ -123837,7 +223189,7 @@ is_a: OBA:0002344 ! epiphysis structure is_a: OBA:1000296 ! distal epiphysis of ulna quality is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0004408 ! distal epiphysis of ulna +intersection_of: RO:0000052 UBERON:0004408 ! inheres in distal epiphysis of ulna [Term] id: OBA:0002715 @@ -123847,8 +223199,8 @@ synonym: "length of pelvic complex" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002373 ! appendage girdle complex size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0010709 ! pelvic complex -relationship: inheres_in UBERON:0010709 ! pelvic complex +intersection_of: RO:0000052 UBERON:0010709 ! inheres in pelvic complex +relationship: RO:0000052 UBERON:0010709 ! inheres in pelvic complex [Term] id: OBA:0002716 @@ -123858,7 +223210,7 @@ synonym: "size of distal epiphysis of radius" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002496 ! epiphysis of radius size is_a: OBA:1000600 ! distal epiphysis of radius quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004407 ! distal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004407 ! inheres in distal epiphysis of radius [Term] id: OBA:0002717 @@ -123867,8 +223219,8 @@ def: "The size of a distal metaphysis of femur." [AUTO:patterns/patterns/entity_ synonym: "size of distal metaphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002723 ! metaphysis of femur size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006864 ! distal metaphysis of femur -relationship: inheres_in UBERON:0006864 ! distal metaphysis of femur +intersection_of: RO:0000052 UBERON:0006864 ! inheres in distal metaphysis of femur +relationship: RO:0000052 UBERON:0006864 ! inheres in distal metaphysis of femur [Term] id: OBA:0002718 @@ -123877,8 +223229,8 @@ def: "The mass density of a long bone." [AUTO:patterns/patterns/entity_attribute synonym: "mass density of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005007 ! bone mineral mass intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0002495 ! long bone -relationship: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone +relationship: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:0002719 @@ -123888,7 +223240,7 @@ synonym: "curvature of distal epiphysis of femur" EXACT [AUTO:patterns/patterns/ is_a: OBA:0002387 ! epiphysis curvature is_a: OBA:1000180 ! distal epiphysis of femur quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004406 ! distal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004406 ! inheres in distal epiphysis of femur [Term] id: OBA:0002720 @@ -123899,8 +223251,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002471 ! zeugopod -relationship: inheres_in UBERON:0002471 ! zeugopod +intersection_of: RO:0000052 UBERON:0002471 ! inheres in zeugopod +relationship: RO:0000052 UBERON:0002471 ! inheres in zeugopod [Term] id: OBA:0002721 @@ -123910,7 +223262,7 @@ synonym: "mass density of distal epiphysis of femur" EXACT [AUTO:patterns/patter is_a: OBA:0002712 ! epiphysis of femur mass density is_a: OBA:1000180 ! distal epiphysis of femur quality intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004406 ! distal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004406 ! inheres in distal epiphysis of femur [Term] id: OBA:0002722 @@ -123919,8 +223271,8 @@ def: "The size of a metaphysis of tibia." [AUTO:patterns/patterns/entity_attribu synonym: "size of metaphysis of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002378 ! metaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013750 ! metaphysis of tibia -relationship: inheres_in UBERON:0013750 ! metaphysis of tibia +intersection_of: RO:0000052 UBERON:0013750 ! inheres in metaphysis of tibia +relationship: RO:0000052 UBERON:0013750 ! inheres in metaphysis of tibia [Term] id: OBA:0002723 @@ -123929,8 +223281,8 @@ def: "The size of a metaphysis of femur." [AUTO:patterns/patterns/entity_attribu synonym: "size of metaphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002378 ! metaphysis size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006865 ! metaphysis of femur -relationship: inheres_in UBERON:0006865 ! metaphysis of femur +intersection_of: RO:0000052 UBERON:0006865 ! inheres in metaphysis of femur +relationship: RO:0000052 UBERON:0006865 ! inheres in metaphysis of femur [Term] id: OBA:0002724 @@ -123940,7 +223292,7 @@ synonym: "amount of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000340 ! tibia quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:0002725 @@ -123949,8 +223301,8 @@ def: "The size of a neck of femur." [AUTO:patterns/patterns/entity_attribute] synonym: "size of neck of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007119 ! neck of femur -relationship: inheres_in UBERON:0007119 ! neck of femur +intersection_of: RO:0000052 UBERON:0007119 ! inheres in neck of femur +relationship: RO:0000052 UBERON:0007119 ! inheres in neck of femur [Term] id: OBA:0002726 @@ -123960,7 +223312,7 @@ synonym: "size of distal epiphysis of femur" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003163 ! epiphysis size is_a: OBA:1000180 ! distal epiphysis of femur quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004406 ! distal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004406 ! inheres in distal epiphysis of femur [Term] id: OBA:0002727 @@ -123970,8 +223322,8 @@ synonym: "amount of patella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002446 ! patella -relationship: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella +relationship: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:0002728 @@ -123981,7 +223333,7 @@ synonym: "structure of patella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0005353 ! patella morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:0002729 @@ -123991,8 +223343,8 @@ synonym: "displaced of head of femur" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0006767 ! head of femur -relationship: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur +relationship: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0002730 @@ -124002,7 +223354,7 @@ synonym: "mass density of proximal epiphysis of tibia" EXACT [AUTO:patterns/patt is_a: OBA:0003164 ! epiphysis mass density is_a: OBA:1000148 ! proximal epiphysis of tibia quality intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0008772 ! proximal epiphysis of tibia +intersection_of: RO:0000052 UBERON:0008772 ! inheres in proximal epiphysis of tibia [Term] id: OBA:0002731 @@ -124012,7 +223364,7 @@ synonym: "amount of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002130 ! calcareous tooth amount is_a: OBA:1000578 ! incisor tooth quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0002732 @@ -124022,7 +223374,7 @@ synonym: "curvature of long bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002163 ! long bone shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:0002733 @@ -124032,7 +223384,7 @@ synonym: "curvature of forelimb stylopod" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0003854 ! forelimb stylopod morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003822 ! forelimb stylopod +intersection_of: RO:0000052 UBERON:0003822 ! inheres in forelimb stylopod [Term] id: OBA:0002734 @@ -124042,7 +223394,7 @@ synonym: "size of cartilage of bronchus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005297 ! cartilage of bronchus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001956 ! cartilage of bronchus +intersection_of: RO:0000052 UBERON:0001956 ! inheres in cartilage of bronchus [Term] id: OBA:0002735 @@ -124052,7 +223404,7 @@ synonym: "composition of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000598 ! liver morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:0002736 @@ -124062,7 +223414,7 @@ synonym: "size of biliary tree" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005083 ! biliary tract morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001173 ! biliary tree +intersection_of: RO:0000052 UBERON:0001173 ! inheres in biliary tree [Term] id: OBA:0002737 @@ -124072,7 +223424,7 @@ synonym: "amount of intrahepatic bile duct" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003800 ! bile duct amount is_a: OBA:1000438 ! intrahepatic bile duct quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003704 ! intrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct [Term] id: OBA:0002738 @@ -124082,7 +223434,7 @@ synonym: "amount of glenoid fossa" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000409 ! glenoid fossa quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006657 ! glenoid fossa +intersection_of: RO:0000052 UBERON:0006657 ! inheres in glenoid fossa [Term] id: OBA:0002739 @@ -124092,8 +223444,8 @@ synonym: "movement behavioral quality of diaphragm" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:0002740 @@ -124103,7 +223455,7 @@ synonym: "mass density of costochondral joint" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000598 ! costochondral joint quality is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0002293 ! costochondral joint +intersection_of: RO:0000052 UBERON:0002293 ! inheres in costochondral joint [Term] id: OBA:0002741 @@ -124113,7 +223465,7 @@ synonym: "size of glenoid fossa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000409 ! glenoid fossa quality is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006657 ! glenoid fossa +intersection_of: RO:0000052 UBERON:0006657 ! inheres in glenoid fossa [Term] id: OBA:0002742 @@ -124122,8 +223474,8 @@ def: "The position of a floating rib." [AUTO:patterns/patterns/entity_attribute] synonym: "position of floating rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002151 ! rib position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002239 ! floating rib -relationship: inheres_in UBERON:0002239 ! floating rib +intersection_of: RO:0000052 UBERON:0002239 ! inheres in floating rib +relationship: RO:0000052 UBERON:0002239 ! inheres in floating rib [Term] id: OBA:0002743 @@ -124133,7 +223485,7 @@ synonym: "structure of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003917 ! chest morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:0002744 @@ -124143,7 +223495,7 @@ synonym: "composition of costal cartilage" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003391 ! cartilage element composition is_a: OBA:VT0010093 ! costal cartilage morphology trait intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002236 ! costal cartilage +intersection_of: RO:0000052 UBERON:0002236 ! inheres in costal cartilage [Term] id: OBA:0002745 @@ -124152,8 +223504,8 @@ def: "The size of a rib 1." [AUTO:patterns/patterns/entity_attribute] synonym: "size of rib 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002150 ! rib size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004601 ! rib 1 -relationship: inheres_in UBERON:0004601 ! rib 1 +intersection_of: RO:0000052 UBERON:0004601 ! inheres in rib 1 +relationship: RO:0000052 UBERON:0004601 ! inheres in rib 1 [Term] id: OBA:0002746 @@ -124163,8 +223515,8 @@ synonym: "rotated of shoulder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001467 ! shoulder -relationship: inheres_in UBERON:0001467 ! shoulder +intersection_of: RO:0000052 UBERON:0001467 ! inheres in shoulder +relationship: RO:0000052 UBERON:0001467 ! inheres in shoulder [Term] id: OBA:0002747 @@ -124173,8 +223525,8 @@ def: "The size of a rib 12." [AUTO:patterns/patterns/entity_attribute] synonym: "size of rib 12" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002150 ! rib size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004611 ! rib 12 -relationship: inheres_in UBERON:0004611 ! rib 12 +intersection_of: RO:0000052 UBERON:0004611 ! inheres in rib 12 +relationship: RO:0000052 UBERON:0004611 ! inheres in rib 12 [Term] id: OBA:0002748 @@ -124184,8 +223536,8 @@ synonym: "amount of atrioventricular node" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002352 ! atrioventricular node -relationship: inheres_in UBERON:0002352 ! atrioventricular node +intersection_of: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node +relationship: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node [Term] id: OBA:0002749 @@ -124196,8 +223548,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005116 ! chorda tendineae morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0014852 ! chorda tendinea of right ventricle -relationship: inheres_in UBERON:0014852 ! chorda tendinea of right ventricle +intersection_of: RO:0000052 UBERON:0014852 ! inheres in chorda tendinea of right ventricle +relationship: RO:0000052 UBERON:0014852 ! inheres in chorda tendinea of right ventricle [Term] id: OBA:0002750 @@ -124207,7 +223559,7 @@ synonym: "size of paranasal sinus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002240 ! paranasal sinus morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001825 ! paranasal sinus +intersection_of: RO:0000052 UBERON:0001825 ! inheres in paranasal sinus [Term] id: OBA:0002751 @@ -124217,7 +223569,7 @@ synonym: "structure of basal ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0006007 ! basal ganglion morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002420 ! basal ganglion +intersection_of: RO:0000052 UBERON:0002420 ! inheres in basal ganglion [Term] id: OBA:0002752 @@ -124226,8 +223578,8 @@ def: "The morphology of a spinal cord motor neuron." [AUTO:patterns/patterns/ent synonym: "morphology of spinal cord motor neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000937 ! motor neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0011001 ! spinal cord motor neuron -relationship: inheres_in CL:0011001 ! spinal cord motor neuron +intersection_of: RO:0000052 CL:0011001 ! inheres in spinal cord motor neuron +relationship: RO:0000052 CL:0011001 ! inheres in spinal cord motor neuron [Term] id: OBA:0002753 @@ -124237,8 +223589,8 @@ synonym: "movement behavioral quality of cranial nerve" EXACT [AUTO:patterns/pat is_a: OBA:1000471 ! nerve quality is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0001785 ! cranial nerve -relationship: inheres_in UBERON:0001785 ! cranial nerve +intersection_of: RO:0000052 UBERON:0001785 ! inheres in cranial nerve +relationship: RO:0000052 UBERON:0001785 ! inheres in cranial nerve [Term] id: OBA:0002754 @@ -124247,8 +223599,8 @@ def: "The size of a basal part of pons." [AUTO:patterns/patterns/entity_attribut synonym: "size of basal part of pons" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002567 ! basal part of pons -relationship: inheres_in UBERON:0002567 ! basal part of pons +intersection_of: RO:0000052 UBERON:0002567 ! inheres in basal part of pons +relationship: RO:0000052 UBERON:0002567 ! inheres in basal part of pons [Term] id: OBA:0002755 @@ -124258,7 +223610,7 @@ synonym: "size of olfactory lobe" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005235 ! olfactory lobe morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005366 ! olfactory lobe +intersection_of: RO:0000052 UBERON:0005366 ! inheres in olfactory lobe [Term] id: OBA:0002756 @@ -124268,7 +223620,7 @@ synonym: "composition of choroid plexus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000820 ! choroid plexus morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001886 ! choroid plexus +intersection_of: RO:0000052 UBERON:0001886 ! inheres in choroid plexus [Term] id: OBA:0002757 @@ -124278,7 +223630,7 @@ synonym: "structure of corpus callosum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000780 ! corpus callosum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002336 ! corpus callosum +intersection_of: RO:0000052 UBERON:0002336 ! inheres in corpus callosum [Term] id: OBA:0002758 @@ -124288,8 +223640,8 @@ synonym: "degeneration of central nervous system" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001017 ! central nervous system -relationship: inheres_in UBERON:0001017 ! central nervous system +intersection_of: RO:0000052 UBERON:0001017 ! inheres in central nervous system +relationship: RO:0000052 UBERON:0001017 ! inheres in central nervous system [Term] id: OBA:0002759 @@ -124299,7 +223651,7 @@ synonym: "size of corticospinal tract" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0002878 ! corticospinal tract morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002707 ! corticospinal tract +intersection_of: RO:0000052 UBERON:0002707 ! inheres in corticospinal tract [Term] id: OBA:0002760 @@ -124309,7 +223661,7 @@ synonym: "size of olfactory tract" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0005237 ! olfactory tract morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002265 ! olfactory tract +intersection_of: RO:0000052 UBERON:0002265 ! inheres in olfactory tract [Term] id: OBA:0002761 @@ -124319,7 +223671,7 @@ synonym: "size of basal ganglion" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0006007 ! basal ganglion morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002420 ! basal ganglion +intersection_of: RO:0000052 UBERON:0002420 ! inheres in basal ganglion [Term] id: OBA:0002762 @@ -124329,7 +223681,7 @@ synonym: "degeneration of globus pallidus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0004081 ! globus pallidus morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001875 ! globus pallidus +intersection_of: RO:0000052 UBERON:0001875 ! inheres in globus pallidus [Term] id: OBA:0002763 @@ -124339,8 +223691,8 @@ synonym: "size of interosseous muscle of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0010647 ! forelimb muscle morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001502 ! interosseous muscle of manus -relationship: inheres_in UBERON:0001502 ! interosseous muscle of manus +intersection_of: RO:0000052 UBERON:0001502 ! inheres in interosseous muscle of manus +relationship: RO:0000052 UBERON:0001502 ! inheres in interosseous muscle of manus [Term] id: OBA:0002764 @@ -124350,8 +223702,8 @@ synonym: "movement behavioral quality of facial muscle" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0001577 ! facial muscle -relationship: inheres_in UBERON:0001577 ! facial muscle +intersection_of: RO:0000052 UBERON:0001577 ! inheres in facial muscle +relationship: RO:0000052 UBERON:0001577 ! inheres in facial muscle [Term] id: OBA:0002765 @@ -124360,8 +223712,8 @@ def: "The size of a musculature of lower limb." [AUTO:patterns/patterns/entity_a synonym: "size of musculature of lower limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002454 ! musculature of limb size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004482 ! musculature of lower limb -relationship: inheres_in UBERON:0004482 ! musculature of lower limb +intersection_of: RO:0000052 UBERON:0004482 ! inheres in musculature of lower limb +relationship: RO:0000052 UBERON:0004482 ! inheres in musculature of lower limb [Term] id: OBA:0002766 @@ -124371,8 +223723,8 @@ synonym: "amount of midbrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001891 ! midbrain -relationship: inheres_in UBERON:0001891 ! midbrain +intersection_of: RO:0000052 UBERON:0001891 ! inheres in midbrain +relationship: RO:0000052 UBERON:0001891 ! inheres in midbrain [Term] id: OBA:0002767 @@ -124382,8 +223734,8 @@ synonym: "functionality of lateral corticospinal tract" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002589 ! lateral corticospinal tract -relationship: inheres_in UBERON:0002589 ! lateral corticospinal tract +intersection_of: RO:0000052 UBERON:0002589 ! inheres in lateral corticospinal tract +relationship: RO:0000052 UBERON:0002589 ! inheres in lateral corticospinal tract [Term] id: OBA:0002768 @@ -124393,8 +223745,8 @@ synonym: "amount of central nervous system myelin maintenance" EXACT [AUTO:patte is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0032286 ! central nervous system myelin maintenance -relationship: inheres_in GO:0032286 ! central nervous system myelin maintenance +intersection_of: RO:0000052 GO:0032286 ! inheres in central nervous system myelin maintenance +relationship: RO:0000052 GO:0032286 ! inheres in central nervous system myelin maintenance [Term] id: OBA:0002769 @@ -124404,7 +223756,7 @@ synonym: "size of frontal cortex" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000798 ! frontal lobe morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001870 ! frontal cortex +intersection_of: RO:0000052 UBERON:0001870 ! inheres in frontal cortex [Term] id: OBA:0002770 @@ -124413,8 +223765,8 @@ def: "The strength of a pelvic complex muscle." [AUTO:patterns/patterns/entity_a synonym: "strength of pelvic complex muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0010890 ! pelvic complex muscle -relationship: inheres_in UBERON:0010890 ! pelvic complex muscle +intersection_of: RO:0000052 UBERON:0010890 ! inheres in pelvic complex muscle +relationship: RO:0000052 UBERON:0010890 ! inheres in pelvic complex muscle [Term] id: OBA:0002771 @@ -124424,8 +223776,8 @@ synonym: "structure of cerebral hemisphere white matter" EXACT [AUTO:patterns/pa is_a: OBA:0004276 ! brain white matter morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002437 ! cerebral hemisphere white matter -relationship: inheres_in UBERON:0002437 ! cerebral hemisphere white matter +intersection_of: RO:0000052 UBERON:0002437 ! inheres in cerebral hemisphere white matter +relationship: RO:0000052 UBERON:0002437 ! inheres in cerebral hemisphere white matter [Term] id: OBA:0002772 @@ -124435,7 +223787,7 @@ synonym: "composition of cerebellum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002317 ! cerebellum structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002037 ! cerebellum +intersection_of: RO:0000052 UBERON:0002037 ! inheres in cerebellum [Term] id: OBA:0002773 @@ -124445,7 +223797,7 @@ synonym: "size of motor neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000937 ! motor neuron morphology trait is_a: OBA:VT0005603 ! neuron size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000100 ! motor neuron +intersection_of: RO:0000052 CL:0000100 ! inheres in motor neuron [Term] id: OBA:0002774 @@ -124455,7 +223807,7 @@ synonym: "texture of skin of body" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0002775 @@ -124464,8 +223816,8 @@ def: "The size of a skin of sole of pes." [AUTO:patterns/patterns/entity_attribu synonym: "size of skin of sole of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003618 ! zone of skin size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013778 ! skin of sole of pes -relationship: inheres_in UBERON:0013778 ! skin of sole of pes +intersection_of: RO:0000052 UBERON:0013778 ! inheres in skin of sole of pes +relationship: RO:0000052 UBERON:0013778 ! inheres in skin of sole of pes [Term] id: OBA:0002776 @@ -124475,8 +223827,8 @@ synonym: "amount of sweat gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001820 ! sweat gland -relationship: inheres_in UBERON:0001820 ! sweat gland +intersection_of: RO:0000052 UBERON:0001820 ! inheres in sweat gland +relationship: RO:0000052 UBERON:0001820 ! inheres in sweat gland [Term] id: OBA:0002777 @@ -124485,8 +223837,8 @@ def: "The size of a pilosebaceous unit." [AUTO:patterns/patterns/entity_attribut synonym: "size of pilosebaceous unit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011932 ! pilosebaceous unit -relationship: inheres_in UBERON:0011932 ! pilosebaceous unit +intersection_of: RO:0000052 UBERON:0011932 ! inheres in pilosebaceous unit +relationship: RO:0000052 UBERON:0011932 ! inheres in pilosebaceous unit [Term] id: OBA:0002778 @@ -124496,7 +223848,7 @@ synonym: "size of stratum corneum of epidermis" EXACT [AUTO:patterns/patterns/en is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001240 ! epidermis stratum corneum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002027 ! stratum corneum of epidermis +intersection_of: RO:0000052 UBERON:0002027 ! inheres in stratum corneum of epidermis [Term] id: OBA:0002779 @@ -124505,8 +223857,8 @@ def: "The texture of a skin of palm of manus." [AUTO:patterns/patterns/entity_at synonym: "texture of skin of palm of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003615 ! zone of skin texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0013777 ! skin of palm of manus -relationship: inheres_in UBERON:0013777 ! skin of palm of manus +intersection_of: RO:0000052 UBERON:0013777 ! inheres in skin of palm of manus +relationship: RO:0000052 UBERON:0013777 ! inheres in skin of palm of manus [Term] id: OBA:0002780 @@ -124515,8 +223867,8 @@ def: "The composition of a superficial fascia." [AUTO:patterns/patterns/entity_a synonym: "composition of superficial fascia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000105 ! tissue composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0011818 ! superficial fascia -relationship: inheres_in UBERON:0011818 ! superficial fascia +intersection_of: RO:0000052 UBERON:0011818 ! inheres in superficial fascia +relationship: RO:0000052 UBERON:0011818 ! inheres in superficial fascia [Term] id: OBA:0002781 @@ -124526,8 +223878,8 @@ synonym: "amount of lower eyelash" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002114 ! eyelash amount is_a: OBA:0002330 ! strand of hair of face amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0019255 ! lower eyelash -relationship: inheres_in UBERON:0019255 ! lower eyelash +intersection_of: RO:0000052 UBERON:0019255 ! inheres in lower eyelash +relationship: RO:0000052 UBERON:0019255 ! inheres in lower eyelash [Term] id: OBA:0002782 @@ -124536,8 +223888,8 @@ def: "The spatial pattern of a lower eyelid." [AUTO:patterns/patterns/entity_att synonym: "spatial pattern of lower eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002127 ! eyelid spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001713 ! lower eyelid -relationship: inheres_in UBERON:0001713 ! lower eyelid +intersection_of: RO:0000052 UBERON:0001713 ! inheres in lower eyelid +relationship: RO:0000052 UBERON:0001713 ! inheres in lower eyelid [Term] id: OBA:0002783 @@ -124547,7 +223899,7 @@ synonym: "shape of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003493 ! strand of hair shape is_a: OBA:VT0004095 ! eyelash morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0002784 @@ -124557,7 +223909,7 @@ synonym: "structure of nasolacrimal duct" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004549 ! nasolacrimal duct morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002392 ! nasolacrimal duct +intersection_of: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct [Term] id: OBA:0002785 @@ -124567,7 +223919,7 @@ synonym: "functionality of pupil" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000396 ! pupil quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:0002786 @@ -124576,8 +223928,8 @@ def: "The size of a lower eyelid." [AUTO:patterns/patterns/entity_attribute] synonym: "size of lower eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003431 ! eyelid size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001713 ! lower eyelid -relationship: inheres_in UBERON:0001713 ! lower eyelid +intersection_of: RO:0000052 UBERON:0001713 ! inheres in lower eyelid +relationship: RO:0000052 UBERON:0001713 ! inheres in lower eyelid [Term] id: OBA:0002787 @@ -124587,7 +223939,7 @@ synonym: "degeneration of cornea" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002113 ! cornea structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0002788 @@ -124597,8 +223949,8 @@ synonym: "strength of extra-ocular muscle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003852 ! eye muscle strength is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001601 ! extra-ocular muscle -relationship: inheres_in UBERON:0001601 ! extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle +relationship: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle [Term] id: OBA:0002789 @@ -124608,7 +223960,7 @@ synonym: "size of lacrimal gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001346 ! lacrimal gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001817 ! lacrimal gland +intersection_of: RO:0000052 UBERON:0001817 ! inheres in lacrimal gland [Term] id: OBA:0002790 @@ -124617,8 +223969,8 @@ def: "The size of a fovea centralis." [AUTO:patterns/patterns/entity_attribute] synonym: "size of fovea centralis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001786 ! fovea centralis -relationship: inheres_in UBERON:0001786 ! fovea centralis +intersection_of: RO:0000052 UBERON:0001786 ! inheres in fovea centralis +relationship: RO:0000052 UBERON:0001786 ! inheres in fovea centralis [Term] id: OBA:0002791 @@ -124628,7 +223980,7 @@ synonym: "opacity of substantia propria of cornea" EXACT [AUTO:patterns/patterns is_a: OBA:1000551 ! substantia propria of cornea quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:0002792 @@ -124638,7 +223990,7 @@ synonym: "size of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001325 ! retina morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:0002793 @@ -124648,7 +224000,7 @@ synonym: "size of ciliary body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005099 ! ciliary body morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001775 ! ciliary body +intersection_of: RO:0000052 UBERON:0001775 ! inheres in ciliary body [Term] id: OBA:0002794 @@ -124658,8 +224010,8 @@ synonym: "spatial pattern of lower eyelash" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002126 ! eyelash spatial pattern is_a: OBA:0002302 ! hair of head spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0019255 ! lower eyelash -relationship: inheres_in UBERON:0019255 ! lower eyelash +intersection_of: RO:0000052 UBERON:0019255 ! inheres in lower eyelash +relationship: RO:0000052 UBERON:0019255 ! inheres in lower eyelash [Term] id: OBA:0002795 @@ -124669,8 +224021,8 @@ synonym: "opacity of posterior pole of lens" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0016459 ! posterior pole of lens -relationship: inheres_in UBERON:0016459 ! posterior pole of lens +intersection_of: RO:0000052 UBERON:0016459 ! inheres in posterior pole of lens +relationship: RO:0000052 UBERON:0016459 ! inheres in posterior pole of lens [Term] id: OBA:0002796 @@ -124680,7 +224032,7 @@ synonym: "closure of lacrimal punctum" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000424 ! lacrimal punctum quality is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0010284 ! lacrimal punctum +intersection_of: RO:0000052 UBERON:0010284 ! inheres in lacrimal punctum [Term] id: OBA:0002797 @@ -124690,8 +224042,8 @@ synonym: "length of upper eyelash" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002110 ! eyelash length is_a: OBA:1000405 ! hair of head quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0019254 ! upper eyelash -relationship: inheres_in UBERON:0019254 ! upper eyelash +intersection_of: RO:0000052 UBERON:0019254 ! inheres in upper eyelash +relationship: RO:0000052 UBERON:0019254 ! inheres in upper eyelash [Term] id: OBA:0002798 @@ -124701,7 +224053,7 @@ synonym: "composition of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001325 ! retina morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:0002799 @@ -124711,8 +224063,8 @@ synonym: "amount of extra-ocular muscle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001601 ! extra-ocular muscle -relationship: inheres_in UBERON:0001601 ! extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle +relationship: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle [Term] id: OBA:0002800 @@ -124722,7 +224074,7 @@ synonym: "size of lacrimal punctum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000424 ! lacrimal punctum quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010284 ! lacrimal punctum +intersection_of: RO:0000052 UBERON:0010284 ! inheres in lacrimal punctum [Term] id: OBA:0002801 @@ -124732,7 +224084,7 @@ synonym: "size of lacrimal drainage system" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0002805 ! lacrimal drainage system morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001850 ! lacrimal drainage system +intersection_of: RO:0000052 UBERON:0001850 ! inheres in lacrimal drainage system [Term] id: OBA:0002802 @@ -124742,8 +224094,8 @@ synonym: "position of epicanthal fold" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0013766 ! epicanthal fold -relationship: inheres_in UBERON:0013766 ! epicanthal fold +intersection_of: RO:0000052 UBERON:0013766 ! inheres in epicanthal fold +relationship: RO:0000052 UBERON:0013766 ! inheres in epicanthal fold [Term] id: OBA:0002803 @@ -124753,8 +224105,8 @@ synonym: "amount of pigmented layer of retina" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001782 ! pigmented layer of retina -relationship: inheres_in UBERON:0001782 ! pigmented layer of retina +intersection_of: RO:0000052 UBERON:0001782 ! inheres in pigmented layer of retina +relationship: RO:0000052 UBERON:0001782 ! inheres in pigmented layer of retina [Term] id: OBA:0002804 @@ -124764,7 +224116,7 @@ synonym: "size of iris stroma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005208 ! iris stroma morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001779 ! iris stroma +intersection_of: RO:0000052 UBERON:0001779 ! inheres in iris stroma [Term] id: OBA:0002805 @@ -124774,7 +224126,7 @@ synonym: "morphology of lacrimal drainage system" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000581 ! lacrimal drainage system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001850 ! lacrimal drainage system +intersection_of: RO:0000052 UBERON:0001850 ! inheres in lacrimal drainage system [Term] id: OBA:0002806 @@ -124784,7 +224136,7 @@ synonym: "spatial pattern of strand of hair" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0002807 @@ -124794,7 +224146,7 @@ synonym: "length of pedal digit 4" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002261 ! pedal digit length is_a: OBA:0003360 ! pedal digit 4 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003634 ! pedal digit 4 +intersection_of: RO:0000052 UBERON:0003634 ! inheres in pedal digit 4 [Term] id: OBA:0002808 @@ -124804,7 +224156,7 @@ synonym: "deviation of pedal digit 3" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002268 ! pedal digit deviation is_a: OBA:1000446 ! pedal digit 3 quality intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003633 ! pedal digit 3 +intersection_of: RO:0000052 UBERON:0003633 ! inheres in pedal digit 3 [Term] id: OBA:0002809 @@ -124814,8 +224166,8 @@ synonym: "length of neck of talus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0015180 ! neck of talus -relationship: inheres_in UBERON:0015180 ! neck of talus +intersection_of: RO:0000052 UBERON:0015180 ! inheres in neck of talus +relationship: RO:0000052 UBERON:0015180 ! inheres in neck of talus [Term] id: OBA:0002810 @@ -124826,7 +224178,7 @@ is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000508 ! tarsal bone quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001447 ! tarsal bone +intersection_of: RO:0000052 UBERON:0001447 ! inheres in tarsal bone [Term] id: OBA:0002811 @@ -124836,7 +224188,7 @@ synonym: "displaced of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003519 ! digit displaced is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0002812 @@ -124845,8 +224197,8 @@ def: "The amount of a helper T cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of helper T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005930 ! effector T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000912 ! helper T cell -relationship: inheres_in CL:0000912 ! helper T cell +intersection_of: RO:0000052 CL:0000912 ! inheres in helper T cell +relationship: RO:0000052 CL:0000912 ! inheres in helper T cell [Term] id: OBA:0002813 @@ -124856,7 +224208,7 @@ synonym: "size of adrenal cortex" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004355 ! adrenal cortex morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001235 ! adrenal cortex +intersection_of: RO:0000052 UBERON:0001235 ! inheres in adrenal cortex [Term] id: OBA:0002814 @@ -124865,8 +224217,8 @@ def: "The onset quality of a development of secondary male sexual characteristic synonym: "onset quality of development of secondary male sexual characteristics" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002147 ! development of secondary sexual characteristics onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0046544 ! development of secondary male sexual characteristics -relationship: inheres_in GO:0046544 ! development of secondary male sexual characteristics +intersection_of: RO:0000052 GO:0046544 ! inheres in development of secondary male sexual characteristics +relationship: RO:0000052 GO:0046544 ! inheres in development of secondary male sexual characteristics [Term] id: OBA:0002815 @@ -124876,7 +224228,7 @@ synonym: "structure of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000681 ! thyroid gland morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:0002816 @@ -124886,8 +224238,8 @@ synonym: "amount of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002046 ! thyroid gland -relationship: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland +relationship: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:0002817 @@ -124897,7 +224249,7 @@ synonym: "amount of development of secondary sexual characteristics" EXACT [AUTO is_a: OBA:1000683 ! development of secondary sexual characteristics quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0045136 ! development of secondary sexual characteristics +intersection_of: RO:0000052 GO:0045136 ! inheres in development of secondary sexual characteristics [Term] id: OBA:0002818 @@ -124907,7 +224259,7 @@ synonym: "structure of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000639 ! adrenal gland morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:0002819 @@ -124917,7 +224269,7 @@ synonym: "size of adrenal medulla" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000643 ! adrenal central medulla morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001236 ! adrenal medulla +intersection_of: RO:0000052 UBERON:0001236 ! inheres in adrenal medulla [Term] id: OBA:0002820 @@ -124927,7 +224279,7 @@ synonym: "size of cerebellar cortex" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0004097 ! cerebellar cortex morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002129 ! cerebellar cortex +intersection_of: RO:0000052 UBERON:0002129 ! inheres in cerebellar cortex [Term] id: OBA:0002821 @@ -124937,8 +224289,8 @@ synonym: "morphology of mitochondrion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005739 ! mitochondrion -relationship: inheres_in GO:0005739 ! mitochondrion +intersection_of: RO:0000052 GO:0005739 ! inheres in mitochondrion +relationship: RO:0000052 GO:0005739 ! inheres in mitochondrion [Term] id: OBA:0002822 @@ -124947,8 +224299,8 @@ def: "The size of a nail of manual digit 5." [AUTO:patterns/patterns/entity_attr synonym: "size of nail of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002257 ! nail of manual digit size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011277 ! nail of manual digit 5 -relationship: inheres_in UBERON:0011277 ! nail of manual digit 5 +intersection_of: RO:0000052 UBERON:0011277 ! inheres in nail of manual digit 5 +relationship: RO:0000052 UBERON:0011277 ! inheres in nail of manual digit 5 [Term] id: OBA:0002823 @@ -124958,7 +224310,7 @@ synonym: "size of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0002824 @@ -124968,7 +224320,7 @@ synonym: "degeneration of intervertebral disk" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0004173 ! intervertebral disk morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:0002825 @@ -124978,7 +224330,7 @@ synonym: "composition of vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0004028 ! vertebra structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0002826 @@ -124988,7 +224340,7 @@ synonym: "2-D shape of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002829 ! vertebra shape is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0002827 @@ -124998,7 +224350,7 @@ synonym: "structure of vertebral column" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0010086 ! vertebral column morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column [Term] id: OBA:0002828 @@ -125007,8 +224359,8 @@ def: "The size of a lumbar vertebra 5." [AUTO:patterns/patterns/entity_attribute synonym: "size of lumbar vertebra 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010518 ! lumbar vertebra size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004621 ! lumbar vertebra 5 -relationship: inheres_in UBERON:0004621 ! lumbar vertebra 5 +intersection_of: RO:0000052 UBERON:0004621 ! inheres in lumbar vertebra 5 +relationship: RO:0000052 UBERON:0004621 ! inheres in lumbar vertebra 5 [Term] id: OBA:0002829 @@ -125018,7 +224370,7 @@ synonym: "shape of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0002830 @@ -125028,7 +224380,7 @@ synonym: "size of cervical vertebra" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002823 ! vertebra size is_a: OBA:0003760 ! cervical vertebra morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0002831 @@ -125038,8 +224390,8 @@ synonym: "amount of coccyx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001350 ! coccyx -relationship: inheres_in UBERON:0001350 ! coccyx +intersection_of: RO:0000052 UBERON:0001350 ! inheres in coccyx +relationship: RO:0000052 UBERON:0001350 ! inheres in coccyx [Term] id: OBA:0002832 @@ -125050,7 +224402,7 @@ is_a: OBA:0002829 ! vertebra shape is_a: OBA:VT0003047 ! thoracic vertebra morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0002347 ! thoracic vertebra +intersection_of: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra [Term] id: OBA:0002833 @@ -125060,8 +224412,8 @@ synonym: "position of nucleus pulposus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002242 ! nucleus pulposus -relationship: inheres_in UBERON:0002242 ! nucleus pulposus +intersection_of: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus +relationship: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus [Term] id: OBA:0002834 @@ -125071,8 +224423,8 @@ synonym: "structure of cervical division of cord spinal central canal" EXACT [AU is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0014542 ! cervical division of cord spinal central canal -relationship: inheres_in UBERON:0014542 ! cervical division of cord spinal central canal +intersection_of: RO:0000052 UBERON:0014542 ! inheres in cervical division of cord spinal central canal +relationship: RO:0000052 UBERON:0014542 ! inheres in cervical division of cord spinal central canal [Term] id: OBA:0002835 @@ -125082,7 +224434,7 @@ synonym: "size of caudal vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002823 ! vertebra size is_a: OBA:VT0002759 ! caudal vertebra morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001095 ! caudal vertebra +intersection_of: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra [Term] id: OBA:0002836 @@ -125092,7 +224444,7 @@ synonym: "structure of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002422 ! bone element structure is_a: OBA:0004993 ! fused sacrum morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0002837 @@ -125102,8 +224454,8 @@ synonym: "growth quality of occurrent of cervical vertebra" EXACT [AUTO:patterns is_a: OBA:1000660 ! trunk or cervical vertebra quality is_a: PATO:0001433 ! growth quality of occurrent intersection_of: PATO:0001433 ! growth quality of occurrent -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra -relationship: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra +relationship: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0002838 @@ -125113,7 +224465,7 @@ synonym: "size of neural spine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000592 ! neural spine quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001076 ! neural spine +intersection_of: RO:0000052 UBERON:0001076 ! inheres in neural spine [Term] id: OBA:0002839 @@ -125122,8 +224474,8 @@ def: "The size of a central part of body of bony vertebral centrum." [AUTO:patte synonym: "size of central part of body of bony vertebral centrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016412 ! central part of body of bony vertebral centrum -relationship: inheres_in UBERON:0016412 ! central part of body of bony vertebral centrum +intersection_of: RO:0000052 UBERON:0016412 ! inheres in central part of body of bony vertebral centrum +relationship: RO:0000052 UBERON:0016412 ! inheres in central part of body of bony vertebral centrum [Term] id: OBA:0002840 @@ -125133,7 +224485,7 @@ synonym: "structure of cervical vertebra" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003760 ! cervical vertebra morphology is_a: OBA:0004028 ! vertebra structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0002841 @@ -125143,7 +224495,7 @@ synonym: "length of bony vertebral centrum" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002843 ! bony vertebral centrum size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002842 @@ -125153,7 +224505,7 @@ synonym: "size of sacral vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002823 ! vertebra size is_a: OBA:0003761 ! sacral vertebra morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001094 ! sacral vertebra +intersection_of: RO:0000052 UBERON:0001094 ! inheres in sacral vertebra [Term] id: OBA:0002843 @@ -125163,7 +224515,7 @@ synonym: "size of bony vertebral centrum" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000141 ! vertebral body morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:0002844 @@ -125173,7 +224525,7 @@ synonym: "surface feature shape of helix of outer ear" EXACT [AUTO:patterns/patt is_a: OBA:1000357 ! helix of outer ear quality is_a: PATO:0001925 ! surface feature shape intersection_of: PATO:0001925 ! surface feature shape -intersection_of: inheres_in UBERON:0002488 ! helix of outer ear +intersection_of: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear [Term] id: OBA:0002845 @@ -125183,8 +224535,8 @@ synonym: "morphology of external ear" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001691 ! external ear -relationship: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear +relationship: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0002846 @@ -125194,8 +224546,8 @@ synonym: "position of antitragus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0016467 ! antitragus -relationship: inheres_in UBERON:0016467 ! antitragus +intersection_of: RO:0000052 UBERON:0016467 ! inheres in antitragus +relationship: RO:0000052 UBERON:0016467 ! inheres in antitragus [Term] id: OBA:0002847 @@ -125204,8 +224556,8 @@ def: "The size of a auricular cartilage." [AUTO:patterns/patterns/entity_attribu synonym: "size of auricular cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001848 ! auricular cartilage -relationship: inheres_in UBERON:0001848 ! auricular cartilage +intersection_of: RO:0000052 UBERON:0001848 ! inheres in auricular cartilage +relationship: RO:0000052 UBERON:0001848 ! inheres in auricular cartilage [Term] id: OBA:0002848 @@ -125214,8 +224566,8 @@ def: "The amount of a development of secondary female sexual characteristics." [ synonym: "amount of development of secondary female sexual characteristics" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002817 ! development of secondary sexual characteristics amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0046543 ! development of secondary female sexual characteristics -relationship: inheres_in GO:0046543 ! development of secondary female sexual characteristics +intersection_of: RO:0000052 GO:0046543 ! inheres in development of secondary female sexual characteristics +relationship: RO:0000052 GO:0046543 ! inheres in development of secondary female sexual characteristics [Term] id: OBA:0002849 @@ -125225,7 +224577,7 @@ synonym: "structure of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000537 ! urethra morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:0002850 @@ -125235,7 +224587,7 @@ synonym: "rate of spermatogenesis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0001156 ! spermatogenesis trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007283 ! spermatogenesis +intersection_of: RO:0000052 GO:0007283 ! inheres in spermatogenesis [Term] id: OBA:0002851 @@ -125245,8 +224597,8 @@ synonym: "amount of internal genitalia" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004175 ! internal genitalia -relationship: inheres_in UBERON:0004175 ! internal genitalia +intersection_of: RO:0000052 UBERON:0004175 ! inheres in internal genitalia +relationship: RO:0000052 UBERON:0004175 ! inheres in internal genitalia [Term] id: OBA:0002852 @@ -125256,7 +224608,7 @@ synonym: "composition of gonad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002016 ! gonad structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000991 ! gonad +intersection_of: RO:0000052 UBERON:0000991 ! inheres in gonad [Term] id: OBA:0002853 @@ -125266,8 +224618,8 @@ synonym: "growth quality of occurrent of testis" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001433 ! growth quality of occurrent intersection_of: PATO:0001433 ! growth quality of occurrent -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:0002854 @@ -125277,7 +224629,7 @@ synonym: "size of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001139 ! vagina morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0002855 @@ -125287,7 +224639,7 @@ synonym: "size of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002249 ! larynx morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:0002856 @@ -125297,7 +224649,7 @@ synonym: "concavity of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002249 ! larynx morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:0002857 @@ -125307,8 +224659,8 @@ synonym: "amount of epiglottis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000388 ! epiglottis -relationship: inheres_in UBERON:0000388 ! epiglottis +intersection_of: RO:0000052 UBERON:0000388 ! inheres in epiglottis +relationship: RO:0000052 UBERON:0000388 ! inheres in epiglottis [Term] id: OBA:0002858 @@ -125318,7 +224670,7 @@ synonym: "composition of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002227 ! larynx structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:0002859 @@ -125328,8 +224680,8 @@ synonym: "curvature of laryngeal vocal fold" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003706 ! laryngeal vocal fold -relationship: inheres_in UBERON:0003706 ! laryngeal vocal fold +intersection_of: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold +relationship: RO:0000052 UBERON:0003706 ! inheres in laryngeal vocal fold [Term] id: OBA:0002860 @@ -125338,8 +224690,8 @@ def: "The size of a proximal metaphysis of femur." [AUTO:patterns/patterns/entit synonym: "size of proximal metaphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002723 ! metaphysis of femur size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006863 ! proximal metaphysis of femur -relationship: inheres_in UBERON:0006863 ! proximal metaphysis of femur +intersection_of: RO:0000052 UBERON:0006863 ! inheres in proximal metaphysis of femur +relationship: RO:0000052 UBERON:0006863 ! inheres in proximal metaphysis of femur [Term] id: OBA:0002861 @@ -125348,8 +224700,8 @@ def: "The convex 3-D shape of a proximal epiphysis of femur." [AUTO:patterns/pat synonym: "convex 3-D shape of proximal epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003162 ! epiphysis convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004412 ! proximal epiphysis of femur -relationship: inheres_in UBERON:0004412 ! proximal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur +relationship: RO:0000052 UBERON:0004412 ! inheres in proximal epiphysis of femur [Term] id: OBA:0002862 @@ -125359,8 +224711,8 @@ synonym: "rotated of hip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001464 ! hip -relationship: inheres_in UBERON:0001464 ! hip +intersection_of: RO:0000052 UBERON:0001464 ! inheres in hip +relationship: RO:0000052 UBERON:0001464 ! inheres in hip [Term] id: OBA:0002863 @@ -125369,8 +224721,8 @@ def: "The size of a lesser trochanter." [AUTO:patterns/patterns/entity_attribute synonym: "size of lesser trochanter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002360 ! trochanter size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002504 ! lesser trochanter -relationship: inheres_in UBERON:0002504 ! lesser trochanter +intersection_of: RO:0000052 UBERON:0002504 ! inheres in lesser trochanter +relationship: RO:0000052 UBERON:0002504 ! inheres in lesser trochanter [Term] id: OBA:0002864 @@ -125379,8 +224731,8 @@ def: "The size of a head of femur." [AUTO:patterns/patterns/entity_attribute] synonym: "size of head of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006767 ! head of femur -relationship: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur +relationship: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0002865 @@ -125390,8 +224742,8 @@ synonym: "shape of head of femur" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006767 ! head of femur -relationship: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur +relationship: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0002866 @@ -125401,7 +224753,7 @@ synonym: "structure of acetabular part of hip bone" EXACT [AUTO:patterns/pattern is_a: OBA:1000334 ! acetabular part of hip bone quality is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001269 ! acetabular part of hip bone +intersection_of: RO:0000052 UBERON:0001269 ! inheres in acetabular part of hip bone [Term] id: OBA:0002867 @@ -125411,7 +224763,7 @@ synonym: "height of iliac blade" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002367 ! iliac blade size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0010746 ! iliac blade +intersection_of: RO:0000052 UBERON:0010746 ! inheres in iliac blade [Term] id: OBA:0002868 @@ -125421,7 +224773,7 @@ synonym: "curvature of head of femur" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002865 ! head of femur shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0002869 @@ -125430,8 +224782,8 @@ def: "The size of a inferior pubic ramus." [AUTO:patterns/patterns/entity_attrib synonym: "size of inferior pubic ramus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002871 ! pubic ramus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014439 ! inferior pubic ramus -relationship: inheres_in UBERON:0014439 ! inferior pubic ramus +intersection_of: RO:0000052 UBERON:0014439 ! inheres in inferior pubic ramus +relationship: RO:0000052 UBERON:0014439 ! inheres in inferior pubic ramus [Term] id: OBA:0002870 @@ -125440,8 +224792,8 @@ def: "The size of a body of ilium." [AUTO:patterns/patterns/entity_attribute] synonym: "size of body of ilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010747 ! body of ilium -relationship: inheres_in UBERON:0010747 ! body of ilium +intersection_of: RO:0000052 UBERON:0010747 ! inheres in body of ilium +relationship: RO:0000052 UBERON:0010747 ! inheres in body of ilium [Term] id: OBA:0002871 @@ -125450,8 +224802,8 @@ def: "The size of a pubic ramus." [AUTO:patterns/patterns/entity_attribute] synonym: "size of pubic ramus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014444 ! pubic ramus -relationship: inheres_in UBERON:0014444 ! pubic ramus +intersection_of: RO:0000052 UBERON:0014444 ! inheres in pubic ramus +relationship: RO:0000052 UBERON:0014444 ! inheres in pubic ramus [Term] id: OBA:0002872 @@ -125461,8 +224813,8 @@ synonym: "size of pelvic region of trunk" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002355 ! pelvic region of trunk -relationship: inheres_in UBERON:0002355 ! pelvic region of trunk +intersection_of: RO:0000052 UBERON:0002355 ! inheres in pelvic region of trunk +relationship: RO:0000052 UBERON:0002355 ! inheres in pelvic region of trunk [Term] id: OBA:0002873 @@ -125471,8 +224823,8 @@ def: "The size of a pelvic complex muscle." [AUTO:patterns/patterns/entity_attri synonym: "size of pelvic complex muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010890 ! pelvic complex muscle -relationship: inheres_in UBERON:0010890 ! pelvic complex muscle +intersection_of: RO:0000052 UBERON:0010890 ! inheres in pelvic complex muscle +relationship: RO:0000052 UBERON:0010890 ! inheres in pelvic complex muscle [Term] id: OBA:0002874 @@ -125482,7 +224834,7 @@ synonym: "rate of mitochondrial respirasome" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000201 ! mitochondrial respirasome quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0005746 ! mitochondrial respirasome +intersection_of: RO:0000052 GO:0005746 ! inheres in mitochondrial respirasome [Term] id: OBA:0002875 @@ -125491,8 +224843,8 @@ def: "The size of a muscle of neck." [AUTO:patterns/patterns/entity_attribute] synonym: "size of muscle of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002377 ! muscle of neck -relationship: inheres_in UBERON:0002377 ! muscle of neck +intersection_of: RO:0000052 UBERON:0002377 ! inheres in muscle of neck +relationship: RO:0000052 UBERON:0002377 ! inheres in muscle of neck [Term] id: OBA:0002876 @@ -125502,8 +224854,8 @@ synonym: "amount of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:0002877 @@ -125512,8 +224864,8 @@ def: "The size of a muscle of pelvic girdle." [AUTO:patterns/patterns/entity_att synonym: "size of muscle of pelvic girdle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002873 ! pelvic complex muscle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001497 ! muscle of pelvic girdle -relationship: inheres_in UBERON:0001497 ! muscle of pelvic girdle +intersection_of: RO:0000052 UBERON:0001497 ! inheres in muscle of pelvic girdle +relationship: RO:0000052 UBERON:0001497 ! inheres in muscle of pelvic girdle [Term] id: OBA:0002878 @@ -125522,8 +224874,8 @@ def: "The size of a pectoralis major." [AUTO:patterns/patterns/entity_attribute] synonym: "size of pectoralis major" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010116 ! pectoralis muscle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002381 ! pectoralis major -relationship: inheres_in UBERON:0002381 ! pectoralis major +intersection_of: RO:0000052 UBERON:0002381 ! inheres in pectoralis major +relationship: RO:0000052 UBERON:0002381 ! inheres in pectoralis major [Term] id: OBA:0002879 @@ -125533,7 +224885,7 @@ synonym: "size of muscle organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0002880 @@ -125543,8 +224895,8 @@ synonym: "size of biceps brachii" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0010647 ! forelimb muscle morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001507 ! biceps brachii -relationship: inheres_in UBERON:0001507 ! biceps brachii +intersection_of: RO:0000052 UBERON:0001507 ! inheres in biceps brachii +relationship: RO:0000052 UBERON:0001507 ! inheres in biceps brachii [Term] id: OBA:0002881 @@ -125553,8 +224905,8 @@ def: "The size of a serratus ventralis." [AUTO:patterns/patterns/entity_attribut synonym: "size of serratus ventralis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003335 ! scapular muscle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001125 ! serratus ventralis -relationship: inheres_in UBERON:0001125 ! serratus ventralis +intersection_of: RO:0000052 UBERON:0001125 ! inheres in serratus ventralis +relationship: RO:0000052 UBERON:0001125 ! inheres in serratus ventralis [Term] id: OBA:0002882 @@ -125564,7 +224916,7 @@ synonym: "amount of gluteal muscle" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000644 ! gluteal muscle quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002000 ! gluteal muscle +intersection_of: RO:0000052 UBERON:0002000 ! inheres in gluteal muscle [Term] id: OBA:0002883 @@ -125574,7 +224926,7 @@ synonym: "altered number of of connective tissue" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0001248 ! connective tissue morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0002384 ! connective tissue +intersection_of: RO:0000052 UBERON:0002384 ! inheres in connective tissue [Term] id: OBA:0002884 @@ -125583,8 +224935,8 @@ def: "The size of a latissimus dorsi muscle." [AUTO:patterns/patterns/entity_att synonym: "size of latissimus dorsi muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003335 ! scapular muscle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001112 ! latissimus dorsi muscle -relationship: inheres_in UBERON:0001112 ! latissimus dorsi muscle +intersection_of: RO:0000052 UBERON:0001112 ! inheres in latissimus dorsi muscle +relationship: RO:0000052 UBERON:0001112 ! inheres in latissimus dorsi muscle [Term] id: OBA:0002885 @@ -125595,8 +224947,8 @@ is_a: OBA:0002873 ! pelvic complex muscle size is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009132 ! peroneus -relationship: inheres_in UBERON:0009132 ! peroneus +intersection_of: RO:0000052 UBERON:0009132 ! inheres in peroneus +relationship: RO:0000052 UBERON:0009132 ! inheres in peroneus [Term] id: OBA:0002886 @@ -125606,7 +224958,7 @@ synonym: "size of quadriceps femoris" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002873 ! pelvic complex muscle size is_a: OBA:VT0010569 ! quadriceps morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001377 ! quadriceps femoris +intersection_of: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris [Term] id: OBA:0002887 @@ -125617,7 +224969,7 @@ is_a: OBA:1000877 ! alveolar process of maxilla quality is_a: OBA:VT0004189 ! alveolar process morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004527 ! alveolar process of maxilla +intersection_of: RO:0000052 UBERON:0004527 ! inheres in alveolar process of maxilla [Term] id: OBA:0002888 @@ -125627,8 +224979,8 @@ synonym: "closure of median palatine suture" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0002835 ! cranial suture morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0016442 ! median palatine suture -relationship: inheres_in UBERON:0016442 ! median palatine suture +intersection_of: RO:0000052 UBERON:0016442 ! inheres in median palatine suture +relationship: RO:0000052 UBERON:0016442 ! inheres in median palatine suture [Term] id: OBA:0002889 @@ -125637,8 +224989,8 @@ def: "The size of a alveolar ridge of mandible." [AUTO:patterns/patterns/entity_ synonym: "size of alveolar ridge of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002031 ! alveolar ridge size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004528 ! alveolar ridge of mandible -relationship: inheres_in UBERON:0004528 ! alveolar ridge of mandible +intersection_of: RO:0000052 UBERON:0004528 ! inheres in alveolar ridge of mandible +relationship: RO:0000052 UBERON:0004528 ! inheres in alveolar ridge of mandible [Term] id: OBA:0002890 @@ -125647,8 +224999,8 @@ def: "The strength of a diaphragm." [AUTO:patterns/patterns/entity_attribute] synonym: "strength of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:0002891 @@ -125658,7 +225010,7 @@ synonym: "altered number of of adipose tissue" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002883 ! connective tissue altered number of is_a: OBA:VT0000003 ! adipose morphology trait intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:0002892 @@ -125667,8 +225019,8 @@ def: "The size of a musculature of upper limb." [AUTO:patterns/patterns/entity_a synonym: "size of musculature of upper limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002454 ! musculature of limb size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004481 ! musculature of upper limb -relationship: inheres_in UBERON:0004481 ! musculature of upper limb +intersection_of: RO:0000052 UBERON:0004481 ! inheres in musculature of upper limb +relationship: RO:0000052 UBERON:0004481 ! inheres in musculature of upper limb [Term] id: OBA:0002893 @@ -125677,8 +225029,8 @@ def: "The size of a musculature of manus." [AUTO:patterns/patterns/entity_attrib synonym: "size of musculature of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002892 ! musculature of upper limb size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004489 ! musculature of manus -relationship: inheres_in UBERON:0004489 ! musculature of manus +intersection_of: RO:0000052 UBERON:0004489 ! inheres in musculature of manus +relationship: RO:0000052 UBERON:0004489 ! inheres in musculature of manus [Term] id: OBA:0002894 @@ -125689,7 +225041,7 @@ is_a: OBA:0002932 ! manual digit 5 phalanx convex 3-D shape is_a: OBA:0003010 ! middle phalanx of manus convex 3-D shape is_a: OBA:1000555 ! middle phalanx of manual digit 5 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:0002895 @@ -125700,7 +225052,7 @@ is_a: OBA:0002931 ! manual digit 5 phalanx size is_a: OBA:0003009 ! middle phalanx of manus size is_a: OBA:1000555 ! middle phalanx of manual digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:0002896 @@ -125709,8 +225061,8 @@ def: "The 2-D shape of a epiphysis of metacarpal bone." [AUTO:patterns/patterns/ synonym: "2-D shape of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003165 ! epiphysis 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002897 @@ -125721,7 +225073,7 @@ is_a: OBA:0002516 ! manual digit 5 phalanx curvature is_a: OBA:0003011 ! middle phalanx of manus curvature is_a: OBA:1000555 ! middle phalanx of manual digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:0002898 @@ -125732,7 +225084,7 @@ is_a: OBA:0002664 ! middle phalanx of manus 2-D shape is_a: OBA:0002933 ! manual digit 5 phalanx 2-D shape is_a: OBA:1000555 ! middle phalanx of manual digit 5 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:0002899 @@ -125741,8 +225093,8 @@ def: "The wholeness of a epiphysis of metacarpal bone." [AUTO:patterns/patterns/ synonym: "wholeness of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003362 ! epiphysis wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002900 @@ -125751,8 +225103,8 @@ def: "The mass density of a epiphysis of metacarpal bone." [AUTO:patterns/patter synonym: "mass density of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003164 ! epiphysis mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002901 @@ -125761,8 +225113,8 @@ def: "The spatial pattern of a epiphysis of metacarpal bone." [AUTO:patterns/pat synonym: "spatial pattern of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003170 ! epiphysis spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002902 @@ -125771,8 +225123,8 @@ def: "The amount of a epiphysis of metacarpal bone." [AUTO:patterns/patterns/ent synonym: "amount of epiphysis of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003160 ! epiphysis amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone -relationship: inheres_in UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone +relationship: RO:0000052 UBERON:0004390 ! inheres in epiphysis of metacarpal bone [Term] id: OBA:0002903 @@ -125782,7 +225134,7 @@ synonym: "length of proximal phalanx of manual digit 5" EXACT [AUTO:patterns/pat is_a: OBA:0002681 ! proximal phalanx of manus length is_a: OBA:0002904 ! proximal phalanx of manual digit 5 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:0002904 @@ -125793,7 +225145,7 @@ is_a: OBA:0002931 ! manual digit 5 phalanx size is_a: OBA:0003012 ! proximal phalanx of manus size is_a: OBA:1000150 ! proximal phalanx of manual digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:0002905 @@ -125804,7 +225156,7 @@ is_a: OBA:0002932 ! manual digit 5 phalanx convex 3-D shape is_a: OBA:0003013 ! proximal phalanx of manus convex 3-D shape is_a: OBA:1000150 ! proximal phalanx of manual digit 5 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:0002906 @@ -125815,7 +225167,7 @@ is_a: OBA:0002516 ! manual digit 5 phalanx curvature is_a: OBA:0003014 ! proximal phalanx of manus curvature is_a: OBA:1000150 ! proximal phalanx of manual digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:0002907 @@ -125826,7 +225178,7 @@ is_a: OBA:0002933 ! manual digit 5 phalanx 2-D shape is_a: OBA:0003301 ! proximal phalanx of manus shape is_a: OBA:1000150 ! proximal phalanx of manual digit 5 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:0002908 @@ -125835,8 +225187,8 @@ def: "The length of a manual digit 5." [AUTO:patterns/patterns/entity_attribute] synonym: "length of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002935 ! manual digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003625 ! manual digit 5 -relationship: inheres_in UBERON:0003625 ! manual digit 5 +intersection_of: RO:0000052 UBERON:0003625 ! inheres in manual digit 5 +relationship: RO:0000052 UBERON:0003625 ! inheres in manual digit 5 [Term] id: OBA:0002909 @@ -125847,7 +225199,7 @@ is_a: OBA:0002931 ! manual digit 5 phalanx size is_a: OBA:0003006 ! distal phalanx of manus size is_a: OBA:1000271 ! distal phalanx of manual digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002910 @@ -125858,7 +225210,7 @@ is_a: OBA:0002932 ! manual digit 5 phalanx convex 3-D shape is_a: OBA:0003007 ! distal phalanx of manus convex 3-D shape is_a: OBA:1000271 ! distal phalanx of manual digit 5 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002911 @@ -125869,7 +225221,7 @@ is_a: OBA:0002933 ! manual digit 5 phalanx 2-D shape is_a: OBA:0003015 ! distal phalanx of manus 2-D shape is_a: OBA:1000271 ! distal phalanx of manual digit 5 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:0002912 @@ -125878,8 +225230,8 @@ def: "The deviation of a manual digit 4." [AUTO:patterns/patterns/entity_attribu synonym: "deviation of manual digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002513 ! manual digit deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003624 ! manual digit 4 -relationship: inheres_in UBERON:0003624 ! manual digit 4 +intersection_of: RO:0000052 UBERON:0003624 ! inheres in manual digit 4 +relationship: RO:0000052 UBERON:0003624 ! inheres in manual digit 4 [Term] id: OBA:0002913 @@ -125888,8 +225240,8 @@ def: "The length of a manual digit 4." [AUTO:patterns/patterns/entity_attribute] synonym: "length of manual digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002935 ! manual digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003624 ! manual digit 4 -relationship: inheres_in UBERON:0003624 ! manual digit 4 +intersection_of: RO:0000052 UBERON:0003624 ! inheres in manual digit 4 +relationship: RO:0000052 UBERON:0003624 ! inheres in manual digit 4 [Term] id: OBA:0002914 @@ -125899,7 +225251,7 @@ synonym: "curvature of manual digit 4 phalanx" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003001 ! phalanx of manus curvature is_a: OBA:1000158 ! manual digit 4 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003638 ! manual digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx [Term] id: OBA:0002915 @@ -125910,7 +225262,7 @@ is_a: OBA:0002914 ! manual digit 4 phalanx curvature is_a: OBA:0003008 ! distal phalanx of manus curvature is_a: OBA:1000291 ! distal phalanx of manual digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:0002916 @@ -125921,7 +225273,7 @@ is_a: OBA:0002914 ! manual digit 4 phalanx curvature is_a: OBA:0003011 ! middle phalanx of manus curvature is_a: OBA:1000208 ! middle phalanx of manual digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:0002917 @@ -125932,7 +225284,7 @@ is_a: OBA:0002914 ! manual digit 4 phalanx curvature is_a: OBA:0003014 ! proximal phalanx of manus curvature is_a: OBA:1000204 ! proximal phalanx of manual digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:0002918 @@ -125942,7 +225294,7 @@ synonym: "length of distal phalanx of manual digit 4" EXACT [AUTO:patterns/patte is_a: OBA:0002919 ! distal phalanx of manual digit 4 size is_a: OBA:0003016 ! distal phalanx of manus length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:0002919 @@ -125953,7 +225305,7 @@ is_a: OBA:0002936 ! manual digit 4 phalanx size is_a: OBA:0003006 ! distal phalanx of manus size is_a: OBA:1000291 ! distal phalanx of manual digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:0002920 @@ -125964,7 +225316,7 @@ is_a: OBA:0002936 ! manual digit 4 phalanx size is_a: OBA:0003009 ! middle phalanx of manus size is_a: OBA:1000208 ! middle phalanx of manual digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:0002921 @@ -125974,7 +225326,7 @@ synonym: "length of middle phalanx of manual digit 4" EXACT [AUTO:patterns/patte is_a: OBA:0002661 ! middle phalanx of manus length is_a: OBA:0002920 ! middle phalanx of manual digit 4 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:0002922 @@ -125985,7 +225337,7 @@ is_a: OBA:0002937 ! manual digit 4 phalanx convex 3-D shape is_a: OBA:0003010 ! middle phalanx of manus convex 3-D shape is_a: OBA:1000208 ! middle phalanx of manual digit 4 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:0002923 @@ -125995,7 +225347,7 @@ synonym: "length of proximal phalanx of manual digit 4" EXACT [AUTO:patterns/pat is_a: OBA:0002681 ! proximal phalanx of manus length is_a: OBA:0002927 ! proximal phalanx of manual digit 4 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:0002924 @@ -126006,7 +225358,7 @@ is_a: OBA:0002937 ! manual digit 4 phalanx convex 3-D shape is_a: OBA:0003007 ! distal phalanx of manus convex 3-D shape is_a: OBA:1000291 ! distal phalanx of manual digit 4 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:0002925 @@ -126017,7 +225369,7 @@ is_a: OBA:0002938 ! manual digit 4 phalanx 2-D shape is_a: OBA:0003015 ! distal phalanx of manus 2-D shape is_a: OBA:1000291 ! distal phalanx of manual digit 4 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:0002926 @@ -126028,7 +225380,7 @@ is_a: OBA:0002664 ! middle phalanx of manus 2-D shape is_a: OBA:0002938 ! manual digit 4 phalanx 2-D shape is_a: OBA:1000208 ! middle phalanx of manual digit 4 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:0002927 @@ -126039,7 +225391,7 @@ is_a: OBA:0002936 ! manual digit 4 phalanx size is_a: OBA:0003012 ! proximal phalanx of manus size is_a: OBA:1000204 ! proximal phalanx of manual digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:0002928 @@ -126050,7 +225402,7 @@ is_a: OBA:0002937 ! manual digit 4 phalanx convex 3-D shape is_a: OBA:0003013 ! proximal phalanx of manus convex 3-D shape is_a: OBA:1000204 ! proximal phalanx of manual digit 4 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:0002929 @@ -126061,7 +225413,7 @@ is_a: OBA:0002938 ! manual digit 4 phalanx 2-D shape is_a: OBA:0003301 ! proximal phalanx of manus shape is_a: OBA:1000204 ! proximal phalanx of manual digit 4 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:0002930 @@ -126070,8 +225422,8 @@ def: "The deviation of a manual digit 3." [AUTO:patterns/patterns/entity_attribu synonym: "deviation of manual digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002513 ! manual digit deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003623 ! manual digit 3 -relationship: inheres_in UBERON:0003623 ! manual digit 3 +intersection_of: RO:0000052 UBERON:0003623 ! inheres in manual digit 3 +relationship: RO:0000052 UBERON:0003623 ! inheres in manual digit 3 [Term] id: OBA:0002931 @@ -126080,8 +225432,8 @@ def: "The size of a manual digit 5 phalanx." [AUTO:patterns/patterns/entity_attr synonym: "size of manual digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002999 ! phalanx of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003639 ! manual digit 5 phalanx -relationship: inheres_in UBERON:0003639 ! manual digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx +relationship: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx [Term] id: OBA:0002932 @@ -126090,8 +225442,8 @@ def: "The convex 3-D shape of a manual digit 5 phalanx." [AUTO:patterns/patterns synonym: "convex 3-D shape of manual digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003000 ! phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003639 ! manual digit 5 phalanx -relationship: inheres_in UBERON:0003639 ! manual digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx +relationship: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx [Term] id: OBA:0002933 @@ -126100,8 +225452,8 @@ def: "The 2-D shape of a manual digit 5 phalanx." [AUTO:patterns/patterns/entity synonym: "2-D shape of manual digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003002 ! phalanx of manus 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003639 ! manual digit 5 phalanx -relationship: inheres_in UBERON:0003639 ! manual digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx +relationship: RO:0000052 UBERON:0003639 ! inheres in manual digit 5 phalanx [Term] id: OBA:0002934 @@ -126110,8 +225462,8 @@ def: "The amount of a manual digit." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003800 ! digit quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002389 ! manual digit -relationship: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit +relationship: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002935 @@ -126121,7 +225473,7 @@ synonym: "length of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002214 ! manual digit size is_a: OBA:VT0002544 ! digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002389 ! manual digit +intersection_of: RO:0000052 UBERON:0002389 ! inheres in manual digit [Term] id: OBA:0002936 @@ -126131,7 +225483,7 @@ synonym: "size of manual digit 4 phalanx" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002999 ! phalanx of manus size is_a: OBA:1000158 ! manual digit 4 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003638 ! manual digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx [Term] id: OBA:0002937 @@ -126141,7 +225493,7 @@ synonym: "convex 3-D shape of manual digit 4 phalanx" EXACT [AUTO:patterns/patte is_a: OBA:0003000 ! phalanx of manus convex 3-D shape is_a: OBA:1000158 ! manual digit 4 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003638 ! manual digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx [Term] id: OBA:0002938 @@ -126151,7 +225503,7 @@ synonym: "2-D shape of manual digit 4 phalanx" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003002 ! phalanx of manus 2-D shape is_a: OBA:1000158 ! manual digit 4 phalanx quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003638 ! manual digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx [Term] id: OBA:0002939 @@ -126162,7 +225514,7 @@ is_a: OBA:0002948 ! manual digit 3 phalanx size is_a: OBA:0003006 ! distal phalanx of manus size is_a: OBA:1000210 ! distal phalanx of manual digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:0002940 @@ -126173,7 +225525,7 @@ is_a: OBA:0002949 ! manual digit 3 phalanx convex 3-D shape is_a: OBA:0003007 ! distal phalanx of manus convex 3-D shape is_a: OBA:1000210 ! distal phalanx of manual digit 3 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:0002941 @@ -126184,7 +225536,7 @@ is_a: OBA:0002951 ! manual digit 3 phalanx 2-D shape is_a: OBA:0003015 ! distal phalanx of manus 2-D shape is_a: OBA:1000210 ! distal phalanx of manual digit 3 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:0002942 @@ -126195,7 +225547,7 @@ is_a: OBA:0002950 ! manual digit 3 phalanx curvature is_a: OBA:0003008 ! distal phalanx of manus curvature is_a: OBA:1000210 ! distal phalanx of manual digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:0002943 @@ -126206,7 +225558,7 @@ is_a: OBA:0002948 ! manual digit 3 phalanx size is_a: OBA:0003009 ! middle phalanx of manus size is_a: OBA:1000526 ! middle phalanx of manual digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:0002944 @@ -126217,7 +225569,7 @@ is_a: OBA:0002949 ! manual digit 3 phalanx convex 3-D shape is_a: OBA:0003010 ! middle phalanx of manus convex 3-D shape is_a: OBA:1000526 ! middle phalanx of manual digit 3 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:0002945 @@ -126228,7 +225580,7 @@ is_a: OBA:0002950 ! manual digit 3 phalanx curvature is_a: OBA:0003011 ! middle phalanx of manus curvature is_a: OBA:1000526 ! middle phalanx of manual digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:0002946 @@ -126239,7 +225591,7 @@ is_a: OBA:0002664 ! middle phalanx of manus 2-D shape is_a: OBA:0002951 ! manual digit 3 phalanx 2-D shape is_a: OBA:1000526 ! middle phalanx of manual digit 3 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:0002947 @@ -126249,7 +225601,7 @@ synonym: "length of middle phalanx of manual digit 3" EXACT [AUTO:patterns/patte is_a: OBA:0002661 ! middle phalanx of manus length is_a: OBA:0002943 ! middle phalanx of manual digit 3 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:0002948 @@ -126258,8 +225610,8 @@ def: "The size of a manual digit 3 phalanx." [AUTO:patterns/patterns/entity_attr synonym: "size of manual digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002999 ! phalanx of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003637 ! manual digit 3 phalanx -relationship: inheres_in UBERON:0003637 ! manual digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx +relationship: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx [Term] id: OBA:0002949 @@ -126268,8 +225620,8 @@ def: "The convex 3-D shape of a manual digit 3 phalanx." [AUTO:patterns/patterns synonym: "convex 3-D shape of manual digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003000 ! phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003637 ! manual digit 3 phalanx -relationship: inheres_in UBERON:0003637 ! manual digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx +relationship: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx [Term] id: OBA:0002950 @@ -126278,8 +225630,8 @@ def: "The curvature of a manual digit 3 phalanx." [AUTO:patterns/patterns/entity synonym: "curvature of manual digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003001 ! phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003637 ! manual digit 3 phalanx -relationship: inheres_in UBERON:0003637 ! manual digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx +relationship: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx [Term] id: OBA:0002951 @@ -126288,8 +225640,8 @@ def: "The 2-D shape of a manual digit 3 phalanx." [AUTO:patterns/patterns/entity synonym: "2-D shape of manual digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003002 ! phalanx of manus 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003637 ! manual digit 3 phalanx -relationship: inheres_in UBERON:0003637 ! manual digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx +relationship: RO:0000052 UBERON:0003637 ! inheres in manual digit 3 phalanx [Term] id: OBA:0002952 @@ -126300,7 +225652,7 @@ is_a: OBA:0002948 ! manual digit 3 phalanx size is_a: OBA:0003012 ! proximal phalanx of manus size is_a: OBA:1000178 ! proximal phalanx of manual digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:0002953 @@ -126311,7 +225663,7 @@ is_a: OBA:0002949 ! manual digit 3 phalanx convex 3-D shape is_a: OBA:0003013 ! proximal phalanx of manus convex 3-D shape is_a: OBA:1000178 ! proximal phalanx of manual digit 3 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:0002954 @@ -126322,7 +225674,7 @@ is_a: OBA:0002950 ! manual digit 3 phalanx curvature is_a: OBA:0003014 ! proximal phalanx of manus curvature is_a: OBA:1000178 ! proximal phalanx of manual digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:0002955 @@ -126333,7 +225685,7 @@ is_a: OBA:0002951 ! manual digit 3 phalanx 2-D shape is_a: OBA:0003301 ! proximal phalanx of manus shape is_a: OBA:1000178 ! proximal phalanx of manual digit 3 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:0002956 @@ -126343,7 +225695,7 @@ synonym: "length of proximal phalanx of manual digit 3" EXACT [AUTO:patterns/pat is_a: OBA:0002681 ! proximal phalanx of manus length is_a: OBA:0002952 ! proximal phalanx of manual digit 3 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:0002957 @@ -126352,8 +225704,8 @@ def: "The length of a manual digit 3." [AUTO:patterns/patterns/entity_attribute] synonym: "length of manual digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002935 ! manual digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003623 ! manual digit 3 -relationship: inheres_in UBERON:0003623 ! manual digit 3 +intersection_of: RO:0000052 UBERON:0003623 ! inheres in manual digit 3 +relationship: RO:0000052 UBERON:0003623 ! inheres in manual digit 3 [Term] id: OBA:0002958 @@ -126362,8 +225714,8 @@ def: "The deviation of a manual digit 2." [AUTO:patterns/patterns/entity_attribu synonym: "deviation of manual digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002513 ! manual digit deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003622 ! manual digit 2 -relationship: inheres_in UBERON:0003622 ! manual digit 2 +intersection_of: RO:0000052 UBERON:0003622 ! inheres in manual digit 2 +relationship: RO:0000052 UBERON:0003622 ! inheres in manual digit 2 [Term] id: OBA:0002959 @@ -126373,8 +225725,8 @@ synonym: "deviation of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004529 ! autopod region spatial pattern is_a: PATO:0002175 ! deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0002398 ! manus -relationship: inheres_in UBERON:0002398 ! manus +intersection_of: RO:0000052 UBERON:0002398 ! inheres in manus +relationship: RO:0000052 UBERON:0002398 ! inheres in manus [Term] id: OBA:0002960 @@ -126383,8 +225735,8 @@ def: "The length of a manual digit 2." [AUTO:patterns/patterns/entity_attribute] synonym: "length of manual digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002935 ! manual digit length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003622 ! manual digit 2 -relationship: inheres_in UBERON:0003622 ! manual digit 2 +intersection_of: RO:0000052 UBERON:0003622 ! inheres in manual digit 2 +relationship: RO:0000052 UBERON:0003622 ! inheres in manual digit 2 [Term] id: OBA:0002961 @@ -126393,8 +225745,8 @@ def: "The 2-D shape of a manual digit 2 phalanx." [AUTO:patterns/patterns/entity synonym: "2-D shape of manual digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003002 ! phalanx of manus 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003636 ! manual digit 2 phalanx -relationship: inheres_in UBERON:0003636 ! manual digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx +relationship: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx [Term] id: OBA:0002962 @@ -126403,8 +225755,8 @@ def: "The size of a manual digit 2 phalanx." [AUTO:patterns/patterns/entity_attr synonym: "size of manual digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002999 ! phalanx of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003636 ! manual digit 2 phalanx -relationship: inheres_in UBERON:0003636 ! manual digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx +relationship: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx [Term] id: OBA:0002963 @@ -126413,8 +225765,8 @@ def: "The convex 3-D shape of a manual digit 2 phalanx." [AUTO:patterns/patterns synonym: "convex 3-D shape of manual digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003000 ! phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003636 ! manual digit 2 phalanx -relationship: inheres_in UBERON:0003636 ! manual digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx +relationship: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx [Term] id: OBA:0002964 @@ -126423,8 +225775,8 @@ def: "The curvature of a manual digit 2 phalanx." [AUTO:patterns/patterns/entity synonym: "curvature of manual digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003001 ! phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003636 ! manual digit 2 phalanx -relationship: inheres_in UBERON:0003636 ! manual digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx +relationship: RO:0000052 UBERON:0003636 ! inheres in manual digit 2 phalanx [Term] id: OBA:0002965 @@ -126434,7 +225786,7 @@ synonym: "size of chordate pharynx" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002234 ! pharynx morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001042 ! chordate pharynx +intersection_of: RO:0000052 UBERON:0001042 ! inheres in chordate pharynx [Term] id: OBA:0002966 @@ -126445,7 +225797,7 @@ is_a: OBA:0002962 ! manual digit 2 phalanx size is_a: OBA:0003006 ! distal phalanx of manus size is_a: OBA:1000325 ! distal phalanx of manual digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:0002967 @@ -126456,7 +225808,7 @@ is_a: OBA:0002963 ! manual digit 2 phalanx convex 3-D shape is_a: OBA:0003007 ! distal phalanx of manus convex 3-D shape is_a: OBA:1000325 ! distal phalanx of manual digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:0002968 @@ -126467,7 +225819,7 @@ is_a: OBA:0002964 ! manual digit 2 phalanx curvature is_a: OBA:0003008 ! distal phalanx of manus curvature is_a: OBA:1000325 ! distal phalanx of manual digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:0002969 @@ -126478,7 +225830,7 @@ is_a: OBA:0002961 ! manual digit 2 phalanx 2-D shape is_a: OBA:0003015 ! distal phalanx of manus 2-D shape is_a: OBA:1000325 ! distal phalanx of manual digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:0002970 @@ -126488,7 +225840,7 @@ synonym: "length of distal phalanx of manual digit 2" EXACT [AUTO:patterns/patte is_a: OBA:0002966 ! distal phalanx of manual digit 2 size is_a: OBA:0003016 ! distal phalanx of manus length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:0002971 @@ -126499,7 +225851,7 @@ is_a: OBA:0002962 ! manual digit 2 phalanx size is_a: OBA:0003009 ! middle phalanx of manus size is_a: OBA:1000510 ! middle phalanx of manual digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:0002972 @@ -126510,7 +225862,7 @@ is_a: OBA:0002963 ! manual digit 2 phalanx convex 3-D shape is_a: OBA:0003010 ! middle phalanx of manus convex 3-D shape is_a: OBA:1000510 ! middle phalanx of manual digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:0002973 @@ -126521,7 +225873,7 @@ is_a: OBA:0002964 ! manual digit 2 phalanx curvature is_a: OBA:0003011 ! middle phalanx of manus curvature is_a: OBA:1000510 ! middle phalanx of manual digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:0002974 @@ -126532,7 +225884,7 @@ is_a: OBA:0002664 ! middle phalanx of manus 2-D shape is_a: OBA:0002961 ! manual digit 2 phalanx 2-D shape is_a: OBA:1000510 ! middle phalanx of manual digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:0002975 @@ -126542,7 +225894,7 @@ synonym: "length of middle phalanx of manual digit 2" EXACT [AUTO:patterns/patte is_a: OBA:0002661 ! middle phalanx of manus length is_a: OBA:0002971 ! middle phalanx of manual digit 2 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:0002976 @@ -126553,7 +225905,7 @@ is_a: OBA:0002962 ! manual digit 2 phalanx size is_a: OBA:0003012 ! proximal phalanx of manus size is_a: OBA:1000228 ! proximal phalanx of manual digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:0002977 @@ -126564,7 +225916,7 @@ is_a: OBA:0002963 ! manual digit 2 phalanx convex 3-D shape is_a: OBA:0003013 ! proximal phalanx of manus convex 3-D shape is_a: OBA:1000228 ! proximal phalanx of manual digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:0002978 @@ -126575,7 +225927,7 @@ is_a: OBA:0002964 ! manual digit 2 phalanx curvature is_a: OBA:0003014 ! proximal phalanx of manus curvature is_a: OBA:1000228 ! proximal phalanx of manual digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:0002979 @@ -126586,7 +225938,7 @@ is_a: OBA:0002961 ! manual digit 2 phalanx 2-D shape is_a: OBA:0003301 ! proximal phalanx of manus shape is_a: OBA:1000228 ! proximal phalanx of manual digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:0002980 @@ -126596,7 +225948,7 @@ synonym: "length of proximal phalanx of manual digit 2" EXACT [AUTO:patterns/pat is_a: OBA:0002681 ! proximal phalanx of manus length is_a: OBA:0002976 ! proximal phalanx of manual digit 2 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:0002981 @@ -126605,8 +225957,8 @@ def: "The amount of a distal phalanx of manual digit 1." [AUTO:patterns/patterns synonym: "amount of distal phalanx of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002660 ! distal phalanx of manus amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002982 @@ -126616,8 +225968,8 @@ synonym: "amount of proximal phalanx of manual digit 1" EXACT [AUTO:patterns/pat is_a: OBA:1000610 ! proximal phalanx of manus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 [Term] id: OBA:0002983 @@ -126626,8 +225978,8 @@ def: "The amount of a metacarpal bone of digit 1." [AUTO:patterns/patterns/entit synonym: "amount of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002669 ! metacarpal bone amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 -relationship: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 +relationship: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0002984 @@ -126637,8 +225989,8 @@ synonym: "concavity of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns is_a: OBA:0002694 ! metacarpal bone shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 -relationship: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 +relationship: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0002985 @@ -126647,8 +225999,8 @@ def: "The displaced of a manual digit 1." [AUTO:patterns/patterns/entity_attribu synonym: "displaced of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003519 ! digit displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 -relationship: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 +relationship: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0002986 @@ -126657,8 +226009,8 @@ def: "The size of a proximal phalanx of manual digit 1." [AUTO:patterns/patterns synonym: "size of proximal phalanx of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003012 ! proximal phalanx of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 [Term] id: OBA:0002987 @@ -126668,8 +226020,8 @@ synonym: "convex 3-D shape of proximal phalanx of manual digit 1" EXACT [AUTO:pa is_a: OBA:0002993 ! manual digit 1 phalanx convex 3-D shape is_a: OBA:0003013 ! proximal phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 [Term] id: OBA:0002988 @@ -126679,8 +226031,8 @@ synonym: "curvature of proximal phalanx of manual digit 1" EXACT [AUTO:patterns/ is_a: OBA:0002994 ! manual digit 1 phalanx curvature is_a: OBA:0003014 ! proximal phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 [Term] id: OBA:0002989 @@ -126691,7 +226043,7 @@ is_a: OBA:0002681 ! proximal phalanx of manus length is_a: OBA:0002986 ! proximal phalanx of manual digit 1 size is_a: OBA:0002995 ! manual digit 1 phalanx length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004338 ! proximal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004338 ! inheres in proximal phalanx of manual digit 1 [Term] id: OBA:0002990 @@ -126700,8 +226052,8 @@ def: "The size of a distal phalanx of manual digit 1." [AUTO:patterns/patterns/e synonym: "size of distal phalanx of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003006 ! distal phalanx of manus size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002991 @@ -126711,8 +226063,8 @@ synonym: "convex 3-D shape of distal phalanx of manual digit 1" EXACT [AUTO:patt is_a: OBA:0002993 ! manual digit 1 phalanx convex 3-D shape is_a: OBA:0003007 ! distal phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002992 @@ -126722,8 +226074,8 @@ synonym: "curvature of distal phalanx of manual digit 1" EXACT [AUTO:patterns/pa is_a: OBA:0002994 ! manual digit 1 phalanx curvature is_a: OBA:0003008 ! distal phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 -relationship: inheres_in UBERON:0004337 ! distal phalanx of manual digit 1 +intersection_of: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 +relationship: RO:0000052 UBERON:0004337 ! inheres in distal phalanx of manual digit 1 [Term] id: OBA:0002993 @@ -126732,8 +226084,8 @@ def: "The convex 3-D shape of a manual digit 1 phalanx." [AUTO:patterns/patterns synonym: "convex 3-D shape of manual digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003000 ! phalanx of manus convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003620 ! manual digit 1 phalanx -relationship: inheres_in UBERON:0003620 ! manual digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx +relationship: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx [Term] id: OBA:0002994 @@ -126742,8 +226094,8 @@ def: "The curvature of a manual digit 1 phalanx." [AUTO:patterns/patterns/entity synonym: "curvature of manual digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003001 ! phalanx of manus curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003620 ! manual digit 1 phalanx -relationship: inheres_in UBERON:0003620 ! manual digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx +relationship: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx [Term] id: OBA:0002995 @@ -126752,8 +226104,8 @@ def: "The length of a manual digit 1 phalanx." [AUTO:patterns/patterns/entity_at synonym: "length of manual digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002683 ! phalanx of manus length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003620 ! manual digit 1 phalanx -relationship: inheres_in UBERON:0003620 ! manual digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx +relationship: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx [Term] id: OBA:0002996 @@ -126762,8 +226114,8 @@ def: "The amount of a manual digit 1." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002934 ! manual digit amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 -relationship: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 +relationship: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0002997 @@ -126772,8 +226124,8 @@ def: "The size of a antihelix." [AUTO:patterns/patterns/entity_attribute] synonym: "size of antihelix" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016466 ! antihelix -relationship: inheres_in UBERON:0016466 ! antihelix +intersection_of: RO:0000052 UBERON:0016466 ! inheres in antihelix +relationship: RO:0000052 UBERON:0016466 ! inheres in antihelix [Term] id: OBA:0002998 @@ -126783,8 +226135,8 @@ synonym: "flexibility of shoulder" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001543 ! flexibility intersection_of: PATO:0001543 ! flexibility -intersection_of: inheres_in UBERON:0001467 ! shoulder -relationship: inheres_in UBERON:0001467 ! shoulder +intersection_of: RO:0000052 UBERON:0001467 ! inheres in shoulder +relationship: RO:0000052 UBERON:0001467 ! inheres in shoulder [Term] id: OBA:0002999 @@ -126795,7 +226147,7 @@ is_a: OBA:0002674 ! phalanx size is_a: OBA:1000632 ! phalanx of manus quality is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0003000 @@ -126808,7 +226160,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0003001 @@ -126821,7 +226173,7 @@ is_a: OBA:1000632 ! phalanx of manus quality is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0003002 @@ -126834,7 +226186,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:0003003 @@ -126844,7 +226196,7 @@ synonym: "length of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002935 ! manual digit length is_a: OBA:0003234 ! manual digit 1 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0003004 @@ -126854,7 +226206,7 @@ synonym: "concavity of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004993 ! fused sacrum morphology is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0003005 @@ -126864,7 +226216,7 @@ synonym: "length of forelimb zeugopod bone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002657 ! forelimb zeugopod bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003466 ! forelimb zeugopod bone +intersection_of: RO:0000052 UBERON:0003466 ! inheres in forelimb zeugopod bone [Term] id: OBA:0003006 @@ -126874,7 +226226,7 @@ synonym: "size of distal phalanx of manus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002999 ! phalanx of manus size is_a: OBA:1000190 ! distal phalanx of manus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003007 @@ -126884,7 +226236,7 @@ synonym: "convex 3-D shape of distal phalanx of manus" EXACT [AUTO:patterns/patt is_a: OBA:0003000 ! phalanx of manus convex 3-D shape is_a: OBA:0003300 ! distal phalanx of manus shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003008 @@ -126894,7 +226246,7 @@ synonym: "curvature of distal phalanx of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003001 ! phalanx of manus curvature is_a: OBA:0003300 ! distal phalanx of manus shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003009 @@ -126904,7 +226256,7 @@ synonym: "size of middle phalanx of manus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002999 ! phalanx of manus size is_a: OBA:1000382 ! middle phalanx of manus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0003010 @@ -126914,7 +226266,7 @@ synonym: "convex 3-D shape of middle phalanx of manus" EXACT [AUTO:patterns/patt is_a: OBA:0003000 ! phalanx of manus convex 3-D shape is_a: OBA:0003299 ! middle phalanx of manus shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0003011 @@ -126924,7 +226276,7 @@ synonym: "curvature of middle phalanx of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003001 ! phalanx of manus curvature is_a: OBA:0003299 ! middle phalanx of manus shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0003012 @@ -126934,7 +226286,7 @@ synonym: "size of proximal phalanx of manus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002999 ! phalanx of manus size is_a: OBA:1000610 ! proximal phalanx of manus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:0003013 @@ -126944,7 +226296,7 @@ synonym: "convex 3-D shape of proximal phalanx of manus" EXACT [AUTO:patterns/pa is_a: OBA:0003000 ! phalanx of manus convex 3-D shape is_a: OBA:0003301 ! proximal phalanx of manus shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:0003014 @@ -126954,7 +226306,7 @@ synonym: "curvature of proximal phalanx of manus" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003001 ! phalanx of manus curvature is_a: OBA:0003301 ! proximal phalanx of manus shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:0003015 @@ -126964,7 +226316,7 @@ synonym: "2-D shape of distal phalanx of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003002 ! phalanx of manus 2-D shape is_a: OBA:0003300 ! distal phalanx of manus shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003016 @@ -126974,7 +226326,7 @@ synonym: "length of distal phalanx of manus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002683 ! phalanx of manus length is_a: OBA:0003006 ! distal phalanx of manus size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003017 @@ -126984,7 +226336,7 @@ synonym: "sharpness of distal phalanx of manus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0002692 ! phalanx of manus sharpness is_a: OBA:0003300 ! distal phalanx of manus shape intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003018 @@ -126993,8 +226345,8 @@ def: "The size of a supraorbital ridge." [AUTO:patterns/patterns/entity_attribut synonym: "size of supraorbital ridge" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011576 ! supraorbital ridge -relationship: inheres_in UBERON:0011576 ! supraorbital ridge +intersection_of: RO:0000052 UBERON:0011576 ! inheres in supraorbital ridge +relationship: RO:0000052 UBERON:0011576 ! inheres in supraorbital ridge [Term] id: OBA:0003019 @@ -127004,8 +226356,8 @@ synonym: "amount of external ear" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001691 ! external ear -relationship: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear +relationship: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0003020 @@ -127016,7 +226368,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000250 ! crus of ear quality is_a: OBA:VT0003737 ! outer ear cartilage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004106 ! crus of ear +intersection_of: RO:0000052 UBERON:0004106 ! inheres in crus of ear [Term] id: OBA:0003021 @@ -127026,7 +226378,7 @@ synonym: "position of crus of ear" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000250 ! crus of ear quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0004106 ! crus of ear +intersection_of: RO:0000052 UBERON:0004106 ! inheres in crus of ear [Term] id: OBA:0003022 @@ -127036,7 +226388,7 @@ synonym: "concavity of helix of outer ear" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000357 ! helix of outer ear quality is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0002488 ! helix of outer ear +intersection_of: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear [Term] id: OBA:0003023 @@ -127046,7 +226398,7 @@ synonym: "position of helix of outer ear" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000357 ! helix of outer ear quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002488 ! helix of outer ear +intersection_of: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear [Term] id: OBA:0003024 @@ -127056,7 +226408,7 @@ synonym: "symmetry of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001312 ! cornea morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0003025 @@ -127066,7 +226418,7 @@ synonym: "displaced of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006241 ! pupil orientation trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:0003026 @@ -127076,8 +226428,8 @@ synonym: "persistence of hyaloid artery" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000301 ! head blood vessel quality is_a: PATO:0000082 ! persistence intersection_of: PATO:0000082 ! persistence -intersection_of: inheres_in UBERON:0002270 ! hyaloid artery -relationship: inheres_in UBERON:0002270 ! hyaloid artery +intersection_of: RO:0000052 UBERON:0002270 ! inheres in hyaloid artery +relationship: RO:0000052 UBERON:0002270 ! inheres in hyaloid artery [Term] id: OBA:0003027 @@ -127087,7 +226439,7 @@ synonym: "symmetry of external naris" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002100 ! external naris spatial pattern is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0003028 @@ -127097,7 +226449,7 @@ synonym: "size of external naris" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002235 ! external nares morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0003029 @@ -127107,8 +226459,8 @@ synonym: "amount of external naris" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005928 ! external naris -relationship: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris +relationship: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0003030 @@ -127118,7 +226470,7 @@ synonym: "symmetry of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003504 ! mandible morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0003031 @@ -127128,7 +226480,7 @@ synonym: "symmetry of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000452 ! mouth morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:0003032 @@ -127141,8 +226493,8 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0003620 ! manual digit 1 phalanx -relationship: inheres_in UBERON:0003620 ! manual digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx +relationship: RO:0000052 UBERON:0003620 ! inheres in manual digit 1 phalanx [Term] id: OBA:0003033 @@ -127151,8 +226503,8 @@ def: "The shape of a epiphysis of first metacarpal bone." [AUTO:patterns/pattern synonym: "shape of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003161 ! epiphysis shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone -relationship: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone +relationship: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003034 @@ -127162,7 +226514,7 @@ synonym: "convex 3-D shape of epiphysis of first metacarpal bone" EXACT [AUTO:pa is_a: OBA:0002679 ! epiphysis of metacarpal bone convex 3-D shape is_a: OBA:0003033 ! epiphysis of first metacarpal bone shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003035 @@ -127171,8 +226523,8 @@ def: "The size of a epiphysis of first metacarpal bone." [AUTO:patterns/patterns synonym: "size of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002682 ! epiphysis of metacarpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone -relationship: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone +relationship: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003036 @@ -127181,8 +226533,8 @@ def: "The wholeness of a epiphysis of first metacarpal bone." [AUTO:patterns/pat synonym: "wholeness of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002899 ! epiphysis of metacarpal bone wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone -relationship: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone +relationship: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003037 @@ -127191,8 +226543,8 @@ def: "The mass density of a epiphysis of first metacarpal bone." [AUTO:patterns/ synonym: "mass density of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002900 ! epiphysis of metacarpal bone mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone -relationship: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone +relationship: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003038 @@ -127201,8 +226553,8 @@ def: "The spatial pattern of a epiphysis of first metacarpal bone." [AUTO:patter synonym: "spatial pattern of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002901 ! epiphysis of metacarpal bone spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone -relationship: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone +relationship: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003039 @@ -127212,7 +226564,7 @@ synonym: "2-D shape of epiphysis of first metacarpal bone" EXACT [AUTO:patterns/ is_a: OBA:0002896 ! epiphysis of metacarpal bone 2-D shape is_a: OBA:0003033 ! epiphysis of first metacarpal bone shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004391 ! epiphysis of first metacarpal bone +intersection_of: RO:0000052 UBERON:0004391 ! inheres in epiphysis of first metacarpal bone [Term] id: OBA:0003040 @@ -127221,8 +226573,8 @@ def: "The size of a metacarpal bone of digit 1." [AUTO:patterns/patterns/entity_ synonym: "size of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002195 ! metacarpal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 -relationship: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 +relationship: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0003041 @@ -127231,8 +226583,8 @@ def: "The convex 3-D shape of a metacarpal bone of digit 1." [AUTO:patterns/patt synonym: "convex 3-D shape of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002687 ! metacarpal bone convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 -relationship: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 +relationship: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0003042 @@ -127242,8 +226594,8 @@ synonym: "curvature of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns is_a: OBA:0002694 ! metacarpal bone shape is_a: OBA:0002732 ! long bone curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 -relationship: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 +relationship: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0003043 @@ -127253,7 +226605,7 @@ synonym: "length of metacarpal bone of digit 1" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003040 ! metacarpal bone of digit 1 size is_a: OBA:0003047 ! metacarpal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003645 ! metacarpal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003645 ! inheres in metacarpal bone of digit 1 [Term] id: OBA:0003044 @@ -127262,8 +226614,8 @@ def: "The length of a metacarpal bone of digit 3." [AUTO:patterns/patterns/entit synonym: "length of metacarpal bone of digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003047 ! metacarpal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003647 ! metacarpal bone of digit 3 -relationship: inheres_in UBERON:0003647 ! metacarpal bone of digit 3 +intersection_of: RO:0000052 UBERON:0003647 ! inheres in metacarpal bone of digit 3 +relationship: RO:0000052 UBERON:0003647 ! inheres in metacarpal bone of digit 3 [Term] id: OBA:0003045 @@ -127272,8 +226624,8 @@ def: "The length of a metacarpal bone of digit 4." [AUTO:patterns/patterns/entit synonym: "length of metacarpal bone of digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003047 ! metacarpal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003648 ! metacarpal bone of digit 4 -relationship: inheres_in UBERON:0003648 ! metacarpal bone of digit 4 +intersection_of: RO:0000052 UBERON:0003648 ! inheres in metacarpal bone of digit 4 +relationship: RO:0000052 UBERON:0003648 ! inheres in metacarpal bone of digit 4 [Term] id: OBA:0003046 @@ -127282,8 +226634,8 @@ def: "The length of a metacarpal bone of digit 5." [AUTO:patterns/patterns/entit synonym: "length of metacarpal bone of digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003047 ! metacarpal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003649 ! metacarpal bone of digit 5 -relationship: inheres_in UBERON:0003649 ! metacarpal bone of digit 5 +intersection_of: RO:0000052 UBERON:0003649 ! inheres in metacarpal bone of digit 5 +relationship: RO:0000052 UBERON:0003649 ! inheres in metacarpal bone of digit 5 [Term] id: OBA:0003047 @@ -127293,7 +226645,7 @@ synonym: "length of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002195 ! metacarpal bone size is_a: OBA:0002381 ! long bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0003048 @@ -127303,7 +226655,7 @@ synonym: "size of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:0004592 ! pedal digit 1 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0003049 @@ -127313,7 +226665,7 @@ synonym: "size of pedal digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000161 ! pedal digit 1 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:0003050 @@ -127323,7 +226675,7 @@ synonym: "convex 3-D shape of pedal digit 1 phalanx" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000161 ! pedal digit 1 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:0003051 @@ -127333,7 +226685,7 @@ synonym: "curvature of pedal digit 1 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000161 ! pedal digit 1 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:0003052 @@ -127343,7 +226695,7 @@ synonym: "2-D shape of pedal digit 1 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000161 ! pedal digit 1 phalanx quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:0003053 @@ -127353,7 +226705,7 @@ synonym: "size of metatarsal bone of digit 1" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002251 ! metatarsal bone size is_a: OBA:1000597 ! metatarsal bone of digit 1 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003054 @@ -127365,7 +226717,7 @@ is_a: OBA:1000597 ! metatarsal bone of digit 1 quality is_a: OBA:VT0003072 ! metatarsus morphology trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003055 @@ -127377,7 +226729,7 @@ is_a: OBA:0005469 ! limb long bone shape is_a: OBA:1000597 ! metatarsal bone of digit 1 quality is_a: OBA:VT0003072 ! metatarsus morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003056 @@ -127389,7 +226741,7 @@ is_a: OBA:1000597 ! metatarsal bone of digit 1 quality is_a: OBA:VT0003072 ! metatarsus morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003057 @@ -127400,7 +226752,7 @@ is_a: OBA:0003049 ! pedal digit 1 phalanx size is_a: OBA:0003079 ! distal phalanx of pes size is_a: OBA:1000571 ! distal phalanx of pedal digit 1 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 [Term] id: OBA:0003058 @@ -127411,7 +226763,7 @@ is_a: OBA:0003050 ! pedal digit 1 phalanx convex 3-D shape is_a: OBA:0003080 ! distal phalanx of pes convex 3-D shape is_a: OBA:1000571 ! distal phalanx of pedal digit 1 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 [Term] id: OBA:0003059 @@ -127422,7 +226774,7 @@ is_a: OBA:0003051 ! pedal digit 1 phalanx curvature is_a: OBA:0003081 ! distal phalanx of pes curvature is_a: OBA:1000571 ! distal phalanx of pedal digit 1 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 [Term] id: OBA:0003060 @@ -127433,7 +226785,7 @@ is_a: OBA:0003052 ! pedal digit 1 phalanx 2-D shape is_a: OBA:0003082 ! distal phalanx of pes 2-D shape is_a: OBA:1000571 ! distal phalanx of pedal digit 1 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 [Term] id: OBA:0003061 @@ -127444,7 +226796,7 @@ is_a: OBA:0003049 ! pedal digit 1 phalanx size is_a: OBA:0003087 ! proximal phalanx of pes size is_a: OBA:1000461 ! proximal phalanx of pedal digit 1 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 [Term] id: OBA:0003062 @@ -127455,7 +226807,7 @@ is_a: OBA:0003050 ! pedal digit 1 phalanx convex 3-D shape is_a: OBA:0003088 ! proximal phalanx of pes convex 3-D shape is_a: OBA:1000461 ! proximal phalanx of pedal digit 1 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 [Term] id: OBA:0003063 @@ -127466,7 +226818,7 @@ is_a: OBA:0003051 ! pedal digit 1 phalanx curvature is_a: OBA:0003089 ! proximal phalanx of pes curvature is_a: OBA:1000461 ! proximal phalanx of pedal digit 1 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 [Term] id: OBA:0003064 @@ -127477,7 +226829,7 @@ is_a: OBA:0003052 ! pedal digit 1 phalanx 2-D shape is_a: OBA:0003090 ! proximal phalanx of pes 2-D shape is_a: OBA:1000461 ! proximal phalanx of pedal digit 1 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 [Term] id: OBA:0003065 @@ -127487,7 +226839,7 @@ synonym: "amount of metatarsal bone of digit 1" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004034 ! metatarsal bone amount is_a: OBA:1000597 ! metatarsal bone of digit 1 quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003066 @@ -127497,7 +226849,7 @@ synonym: "length of metatarsal bone of digit 1" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003053 ! metatarsal bone of digit 1 size is_a: OBA:0004033 ! metatarsal bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:0003067 @@ -127507,7 +226859,7 @@ synonym: "length of pedal digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002588 ! phalanx of pes length is_a: OBA:0003049 ! pedal digit 1 phalanx size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:0003068 @@ -127517,7 +226869,7 @@ synonym: "shape of epiphysis of first metatarsal bone" EXACT [AUTO:patterns/patt is_a: OBA:0003161 ! epiphysis shape is_a: OBA:1000590 ! epiphysis of first metatarsal bone quality intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003069 @@ -127527,7 +226879,7 @@ synonym: "convex 3-D shape of epiphysis of first metatarsal bone" EXACT [AUTO:pa is_a: OBA:0003068 ! epiphysis of first metatarsal bone shape is_a: OBA:0003162 ! epiphysis convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003070 @@ -127537,7 +226889,7 @@ synonym: "size of epiphysis of first metatarsal bone" EXACT [AUTO:patterns/patte is_a: OBA:0003163 ! epiphysis size is_a: OBA:1000590 ! epiphysis of first metatarsal bone quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003071 @@ -127547,7 +226899,7 @@ synonym: "wholeness of epiphysis of first metatarsal bone" EXACT [AUTO:patterns/ is_a: OBA:0003362 ! epiphysis wholeness is_a: OBA:1000590 ! epiphysis of first metatarsal bone quality intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003072 @@ -127557,7 +226909,7 @@ synonym: "mass density of epiphysis of first metatarsal bone" EXACT [AUTO:patter is_a: OBA:0003164 ! epiphysis mass density is_a: OBA:1000590 ! epiphysis of first metatarsal bone quality intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003073 @@ -127567,7 +226919,7 @@ synonym: "spatial pattern of epiphysis of first metatarsal bone" EXACT [AUTO:pat is_a: OBA:0003170 ! epiphysis spatial pattern is_a: OBA:1000590 ! epiphysis of first metatarsal bone quality intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003074 @@ -127577,7 +226929,7 @@ synonym: "2-D shape of epiphysis of first metatarsal bone" EXACT [AUTO:patterns/ is_a: OBA:0003068 ! epiphysis of first metatarsal bone shape is_a: OBA:0003165 ! epiphysis 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:0003075 @@ -127588,7 +226940,7 @@ is_a: OBA:0002674 ! phalanx size is_a: OBA:1000501 ! phalanx of pes quality is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:0003076 @@ -127601,7 +226953,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010105 ! hindlimb long bone morphology trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:0003077 @@ -127614,7 +226966,7 @@ is_a: OBA:1000501 ! phalanx of pes quality is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:0003078 @@ -127627,7 +226979,7 @@ is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010105 ! hindlimb long bone morphology trait is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:0003079 @@ -127637,7 +226989,7 @@ synonym: "size of distal phalanx of pes" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0003080 @@ -127647,7 +226999,7 @@ synonym: "convex 3-D shape of distal phalanx of pes" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0003081 @@ -127657,7 +227009,7 @@ synonym: "curvature of distal phalanx of pes" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0003082 @@ -127667,7 +227019,7 @@ synonym: "2-D shape of distal phalanx of pes" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:0003083 @@ -127677,7 +227029,7 @@ synonym: "size of middle phalanx of pes" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:0003084 @@ -127687,7 +227039,7 @@ synonym: "convex 3-D shape of middle phalanx of pes" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:0003085 @@ -127697,7 +227049,7 @@ synonym: "curvature of middle phalanx of pes" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:0003086 @@ -127707,7 +227059,7 @@ synonym: "2-D shape of middle phalanx of pes" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:0003087 @@ -127717,7 +227069,7 @@ synonym: "size of proximal phalanx of pes" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000212 ! proximal phalanx of pes quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:0003088 @@ -127727,7 +227079,7 @@ synonym: "convex 3-D shape of proximal phalanx of pes" EXACT [AUTO:patterns/patt is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000212 ! proximal phalanx of pes quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:0003089 @@ -127737,7 +227089,7 @@ synonym: "curvature of proximal phalanx of pes" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000212 ! proximal phalanx of pes quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:0003090 @@ -127747,7 +227099,7 @@ synonym: "2-D shape of proximal phalanx of pes" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000212 ! proximal phalanx of pes quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:0003091 @@ -127757,7 +227109,7 @@ synonym: "shape of epiphysis of phalanx of manus" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003161 ! epiphysis shape is_a: OBA:1000183 ! epiphysis of phalanx of manus quality intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003092 @@ -127767,7 +227119,7 @@ synonym: "convex 3-D shape of epiphysis of phalanx of manus" EXACT [AUTO:pattern is_a: OBA:0003091 ! epiphysis of phalanx of manus shape is_a: OBA:0003162 ! epiphysis convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003093 @@ -127777,7 +227129,7 @@ synonym: "size of epiphysis of phalanx of manus" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003163 ! epiphysis size is_a: OBA:1000183 ! epiphysis of phalanx of manus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003094 @@ -127787,7 +227139,7 @@ synonym: "wholeness of epiphysis of phalanx of manus" EXACT [AUTO:patterns/patte is_a: OBA:0003362 ! epiphysis wholeness is_a: OBA:1000183 ! epiphysis of phalanx of manus quality intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003095 @@ -127797,7 +227149,7 @@ synonym: "mass density of epiphysis of phalanx of manus" EXACT [AUTO:patterns/pa is_a: OBA:0003164 ! epiphysis mass density is_a: OBA:1000183 ! epiphysis of phalanx of manus quality intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003096 @@ -127807,7 +227159,7 @@ synonym: "spatial pattern of epiphysis of phalanx of manus" EXACT [AUTO:patterns is_a: OBA:0003170 ! epiphysis spatial pattern is_a: OBA:1000183 ! epiphysis of phalanx of manus quality intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:0003097 @@ -127817,7 +227169,7 @@ synonym: "closure of lower lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005682 ! lower lip morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001835 ! lower lip +intersection_of: RO:0000052 UBERON:0001835 ! inheres in lower lip [Term] id: OBA:0003098 @@ -127827,7 +227179,7 @@ synonym: "size of lower lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003868 ! lip size is_a: OBA:0005682 ! lower lip morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001835 ! lower lip +intersection_of: RO:0000052 UBERON:0001835 ! inheres in lower lip [Term] id: OBA:0003099 @@ -127837,7 +227189,7 @@ synonym: "concavity of alveolar ridge" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0004189 ! alveolar process morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0004103 ! alveolar ridge +intersection_of: RO:0000052 UBERON:0004103 ! inheres in alveolar ridge [Term] id: OBA:0003100 @@ -127847,7 +227199,7 @@ synonym: "size of hard palate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003756 ! hard palate morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003216 ! hard palate +intersection_of: RO:0000052 UBERON:0003216 ! inheres in hard palate [Term] id: OBA:0003101 @@ -127857,8 +227209,8 @@ synonym: "amount of palatine uvula" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001734 ! palatine uvula -relationship: inheres_in UBERON:0001734 ! palatine uvula +intersection_of: RO:0000052 UBERON:0001734 ! inheres in palatine uvula +relationship: RO:0000052 UBERON:0001734 ! inheres in palatine uvula [Term] id: OBA:0003102 @@ -127868,7 +227220,7 @@ synonym: "concavity of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000762 ! tongue morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0003103 @@ -127878,8 +227230,8 @@ synonym: "closure of arch of centrum of vertebra" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0010358 ! arch of centrum of vertebra -relationship: inheres_in UBERON:0010358 ! arch of centrum of vertebra +intersection_of: RO:0000052 UBERON:0010358 ! inheres in arch of centrum of vertebra +relationship: RO:0000052 UBERON:0010358 ! inheres in arch of centrum of vertebra [Term] id: OBA:0003104 @@ -127889,8 +227241,8 @@ synonym: "amount of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003690 ! fused sacrum -relationship: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum +relationship: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0003105 @@ -127900,7 +227252,7 @@ synonym: "length of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002620 ! chest size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:0003106 @@ -127910,8 +227262,8 @@ synonym: "amount of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000975 ! sternum -relationship: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum +relationship: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:0003107 @@ -127921,7 +227273,7 @@ synonym: "branchiness of sternum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0004320 ! sternum shape trait is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:0003108 @@ -127931,8 +227283,8 @@ synonym: "symmetry of breast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0000310 ! breast -relationship: inheres_in UBERON:0000310 ! breast +intersection_of: RO:0000052 UBERON:0000310 ! inheres in breast +relationship: RO:0000052 UBERON:0000310 ! inheres in breast [Term] id: OBA:0003109 @@ -127941,8 +227293,8 @@ def: "The onset quality of a thelarche." [AUTO:patterns/patterns/entity_attribut synonym: "onset quality of thelarche" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003146 ! development of secondary female sexual characteristics onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0042695 ! thelarche -relationship: inheres_in GO:0042695 ! thelarche +intersection_of: RO:0000052 GO:0042695 ! inheres in thelarche +relationship: RO:0000052 GO:0042695 ! inheres in thelarche [Term] id: OBA:0003110 @@ -127952,7 +227304,7 @@ synonym: "deviation of pedal digit 4" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002268 ! pedal digit deviation is_a: OBA:1000269 ! pedal digit 4 quality intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0003634 ! pedal digit 4 +intersection_of: RO:0000052 UBERON:0003634 ! inheres in pedal digit 4 [Term] id: OBA:0003111 @@ -127962,7 +227314,7 @@ synonym: "size of pedal digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000353 ! pedal digit 2 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003641 ! pedal digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx [Term] id: OBA:0003112 @@ -127972,7 +227324,7 @@ synonym: "convex 3-D shape of pedal digit 2 phalanx" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000353 ! pedal digit 2 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003641 ! pedal digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx [Term] id: OBA:0003113 @@ -127982,7 +227334,7 @@ synonym: "curvature of pedal digit 2 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000353 ! pedal digit 2 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003641 ! pedal digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx [Term] id: OBA:0003114 @@ -127992,7 +227344,7 @@ synonym: "2-D shape of pedal digit 2 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000353 ! pedal digit 2 phalanx quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003641 ! pedal digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx [Term] id: OBA:0003115 @@ -128002,7 +227354,7 @@ synonym: "size of pedal digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000378 ! pedal digit 3 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003642 ! pedal digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003642 ! inheres in pedal digit 3 phalanx [Term] id: OBA:0003116 @@ -128012,7 +227364,7 @@ synonym: "convex 3-D shape of pedal digit 3 phalanx" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000378 ! pedal digit 3 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003642 ! pedal digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003642 ! inheres in pedal digit 3 phalanx [Term] id: OBA:0003117 @@ -128022,7 +227374,7 @@ synonym: "curvature of pedal digit 3 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000378 ! pedal digit 3 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003642 ! pedal digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003642 ! inheres in pedal digit 3 phalanx [Term] id: OBA:0003118 @@ -128032,7 +227384,7 @@ synonym: "2-D shape of proximal phalanx of pedal digit 3" EXACT [AUTO:patterns/p is_a: OBA:0003090 ! proximal phalanx of pes 2-D shape is_a: OBA:1000422 ! proximal phalanx of pedal digit 3 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004334 ! proximal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004334 ! inheres in proximal phalanx of pedal digit 3 [Term] id: OBA:0003119 @@ -128042,7 +227394,7 @@ synonym: "size of pedal digit 4 phalanx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003862 ! pedal digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx [Term] id: OBA:0003120 @@ -128052,7 +227404,7 @@ synonym: "convex 3-D shape of pedal digit 4 phalanx" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003862 ! pedal digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx [Term] id: OBA:0003121 @@ -128062,7 +227414,7 @@ synonym: "curvature of pedal digit 4 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003862 ! pedal digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx [Term] id: OBA:0003122 @@ -128072,7 +227424,7 @@ synonym: "2-D shape of pedal digit 4 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003862 ! pedal digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx [Term] id: OBA:0003123 @@ -128082,7 +227434,7 @@ synonym: "size of pedal digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003075 ! phalanx of pes size is_a: OBA:1000329 ! pedal digit 5 phalanx quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003863 ! pedal digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx [Term] id: OBA:0003124 @@ -128092,7 +227444,7 @@ synonym: "convex 3-D shape of pedal digit 5 phalanx" EXACT [AUTO:patterns/patter is_a: OBA:0003076 ! phalanx of pes convex 3-D shape is_a: OBA:1000329 ! pedal digit 5 phalanx quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003863 ! pedal digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx [Term] id: OBA:0003125 @@ -128102,7 +227454,7 @@ synonym: "curvature of pedal digit 5 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003077 ! phalanx of pes curvature is_a: OBA:1000329 ! pedal digit 5 phalanx quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003863 ! pedal digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx [Term] id: OBA:0003126 @@ -128112,7 +227464,7 @@ synonym: "2-D shape of pedal digit 5 phalanx" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003078 ! phalanx of pes 2-D shape is_a: OBA:1000329 ! pedal digit 5 phalanx quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0003863 ! pedal digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx [Term] id: OBA:0003127 @@ -128123,7 +227475,7 @@ is_a: OBA:0003087 ! proximal phalanx of pes size is_a: OBA:0003111 ! pedal digit 2 phalanx size is_a: OBA:1000170 ! proximal phalanx of pedal digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 [Term] id: OBA:0003128 @@ -128134,7 +227486,7 @@ is_a: OBA:0003088 ! proximal phalanx of pes convex 3-D shape is_a: OBA:0003112 ! pedal digit 2 phalanx convex 3-D shape is_a: OBA:1000170 ! proximal phalanx of pedal digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 [Term] id: OBA:0003129 @@ -128145,7 +227497,7 @@ is_a: OBA:0003089 ! proximal phalanx of pes curvature is_a: OBA:0003113 ! pedal digit 2 phalanx curvature is_a: OBA:1000170 ! proximal phalanx of pedal digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 [Term] id: OBA:0003130 @@ -128156,7 +227508,7 @@ is_a: OBA:0003090 ! proximal phalanx of pes 2-D shape is_a: OBA:0003114 ! pedal digit 2 phalanx 2-D shape is_a: OBA:1000170 ! proximal phalanx of pedal digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 [Term] id: OBA:0003131 @@ -128167,7 +227519,7 @@ is_a: OBA:0003083 ! middle phalanx of pes size is_a: OBA:0003111 ! pedal digit 2 phalanx size is_a: OBA:1000389 ! middle phalanx of pedal digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:0003132 @@ -128178,7 +227530,7 @@ is_a: OBA:0003084 ! middle phalanx of pes convex 3-D shape is_a: OBA:0003112 ! pedal digit 2 phalanx convex 3-D shape is_a: OBA:1000389 ! middle phalanx of pedal digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:0003133 @@ -128189,7 +227541,7 @@ is_a: OBA:0003085 ! middle phalanx of pes curvature is_a: OBA:0003113 ! pedal digit 2 phalanx curvature is_a: OBA:1000389 ! middle phalanx of pedal digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:0003134 @@ -128200,7 +227552,7 @@ is_a: OBA:0003086 ! middle phalanx of pes 2-D shape is_a: OBA:0003114 ! pedal digit 2 phalanx 2-D shape is_a: OBA:1000389 ! middle phalanx of pedal digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:0003135 @@ -128211,7 +227563,7 @@ is_a: OBA:0003079 ! distal phalanx of pes size is_a: OBA:0003111 ! pedal digit 2 phalanx size is_a: OBA:1000427 ! distal phalanx of pedal digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 [Term] id: OBA:0003136 @@ -128222,7 +227574,7 @@ is_a: OBA:0003080 ! distal phalanx of pes convex 3-D shape is_a: OBA:0003112 ! pedal digit 2 phalanx convex 3-D shape is_a: OBA:1000427 ! distal phalanx of pedal digit 2 quality intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 [Term] id: OBA:0003137 @@ -128233,7 +227585,7 @@ is_a: OBA:0003081 ! distal phalanx of pes curvature is_a: OBA:0003113 ! pedal digit 2 phalanx curvature is_a: OBA:1000427 ! distal phalanx of pedal digit 2 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 [Term] id: OBA:0003138 @@ -128244,7 +227596,7 @@ is_a: OBA:0003082 ! distal phalanx of pes 2-D shape is_a: OBA:0003114 ! pedal digit 2 phalanx 2-D shape is_a: OBA:1000427 ! distal phalanx of pedal digit 2 quality intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 [Term] id: OBA:0003139 @@ -128254,7 +227606,7 @@ synonym: "amount of middle phalanx of pedal digit 2" EXACT [AUTO:patterns/patter is_a: OBA:1000389 ! middle phalanx of pedal digit 2 quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:0003140 @@ -128265,7 +227617,7 @@ is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0000559 ! femur morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:0003141 @@ -128274,8 +227626,8 @@ def: "The sufficiency of a pulmonary valve." [AUTO:patterns/patterns/entity_attr synonym: "sufficiency of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004176 ! semi-lunar valve sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve -relationship: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve +relationship: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0003142 @@ -128285,7 +227637,7 @@ synonym: "closure of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000495 ! colon morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:0003143 @@ -128295,8 +227647,8 @@ synonym: "structure of lumen of esophagus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0011566 ! lumen of esophagus -relationship: inheres_in UBERON:0011566 ! lumen of esophagus +intersection_of: RO:0000052 UBERON:0011566 ! inheres in lumen of esophagus +relationship: RO:0000052 UBERON:0011566 ! inheres in lumen of esophagus [Term] id: OBA:0003144 @@ -128306,8 +227658,8 @@ synonym: "displaced of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:0003145 @@ -128317,7 +227669,7 @@ synonym: "symmetry of pelvic girdle bone/zone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0007830 ! pelvic girdle bone/zone +intersection_of: RO:0000052 UBERON:0007830 ! inheres in pelvic girdle bone/zone [Term] id: OBA:0003146 @@ -128326,8 +227678,8 @@ def: "The onset quality of a development of secondary female sexual characterist synonym: "onset quality of development of secondary female sexual characteristics" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002147 ! development of secondary sexual characteristics onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0046543 ! development of secondary female sexual characteristics -relationship: inheres_in GO:0046543 ! development of secondary female sexual characteristics +intersection_of: RO:0000052 GO:0046543 ! inheres in development of secondary female sexual characteristics +relationship: RO:0000052 GO:0046543 ! inheres in development of secondary female sexual characteristics [Term] id: OBA:0003147 @@ -128337,8 +227689,8 @@ synonym: "amount of testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:0003148 @@ -128347,8 +227699,8 @@ def: "The size of a pectoral complex." [AUTO:patterns/patterns/entity_attribute] synonym: "size of pectoral complex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002373 ! appendage girdle complex size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010708 ! pectoral complex -relationship: inheres_in UBERON:0010708 ! pectoral complex +intersection_of: RO:0000052 UBERON:0010708 ! inheres in pectoral complex +relationship: RO:0000052 UBERON:0010708 ! inheres in pectoral complex [Term] id: OBA:0003149 @@ -128357,8 +227709,8 @@ def: "The size of a hypothenar eminence." [AUTO:patterns/patterns/entity_attribu synonym: "size of hypothenar eminence" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0017717 ! hypothenar eminence -relationship: inheres_in UBERON:0017717 ! hypothenar eminence +intersection_of: RO:0000052 UBERON:0017717 ! inheres in hypothenar eminence +relationship: RO:0000052 UBERON:0017717 ! inheres in hypothenar eminence [Term] id: OBA:0003150 @@ -128368,8 +227720,8 @@ synonym: "size of leg" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000978 ! leg -relationship: inheres_in UBERON:0000978 ! leg +intersection_of: RO:0000052 UBERON:0000978 ! inheres in leg +relationship: RO:0000052 UBERON:0000978 ! inheres in leg [Term] id: OBA:0003151 @@ -128379,8 +227731,8 @@ synonym: "symmetry of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004529 ! autopod region spatial pattern is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002387 ! pes -relationship: inheres_in UBERON:0002387 ! pes +intersection_of: RO:0000052 UBERON:0002387 ! inheres in pes +relationship: RO:0000052 UBERON:0002387 ! inheres in pes [Term] id: OBA:0003152 @@ -128390,7 +227742,7 @@ synonym: "composition of adrenal gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0002818 ! adrenal gland structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:0003153 @@ -128400,7 +227752,7 @@ synonym: "composition of pituitary gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000633 ! pituitary gland morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:0003154 @@ -128410,7 +227762,7 @@ synonym: "size of cranial suture" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002383 ! skeletal joint size is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003685 ! cranial suture +intersection_of: RO:0000052 UBERON:0003685 ! inheres in cranial suture [Term] id: OBA:0003155 @@ -128420,7 +227772,7 @@ synonym: "spatial pattern of clivus of occipital bone" EXACT [AUTO:patterns/patt is_a: OBA:1000274 ! clivus of occipital bone quality is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004108 ! clivus of occipital bone +intersection_of: RO:0000052 UBERON:0004108 ! inheres in clivus of occipital bone [Term] id: OBA:0003156 @@ -128430,7 +227782,7 @@ synonym: "shape of clavicle bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002163 ! long bone shape is_a: OBA:VT0005298 ! clavicle morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001105 ! clavicle bone +intersection_of: RO:0000052 UBERON:0001105 ! inheres in clavicle bone [Term] id: OBA:0003157 @@ -128440,7 +227792,7 @@ synonym: "shape of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000150 ! rib morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0003158 @@ -128450,7 +227802,7 @@ synonym: "concavity of epiglottis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002259 ! epiglottis morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000388 ! epiglottis +intersection_of: RO:0000052 UBERON:0000388 ! inheres in epiglottis [Term] id: OBA:0003159 @@ -128460,8 +227812,8 @@ synonym: "structure of head of femur" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0006767 ! head of femur -relationship: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur +relationship: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0003160 @@ -128471,8 +227823,8 @@ synonym: "amount of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001437 ! epiphysis -relationship: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis +relationship: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003161 @@ -128482,7 +227834,7 @@ synonym: "shape of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000131 ! long bone epiphysis morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003162 @@ -128492,7 +227844,7 @@ synonym: "convex 3-D shape of epiphysis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003161 ! epiphysis shape is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003163 @@ -128502,7 +227854,7 @@ synonym: "size of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000131 ! long bone epiphysis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003164 @@ -128512,8 +227864,8 @@ synonym: "mass density of epiphysis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001437 ! epiphysis -relationship: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis +relationship: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003165 @@ -128523,7 +227875,7 @@ synonym: "2-D shape of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003161 ! epiphysis shape is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003166 @@ -128533,7 +227885,7 @@ synonym: "position of zygomatic arch" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000511 ! zygomatic arch quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002500 ! zygomatic arch +intersection_of: RO:0000052 UBERON:0002500 ! inheres in zygomatic arch [Term] id: OBA:0003167 @@ -128543,7 +227895,7 @@ synonym: "size of adenohypophysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004163 ! adenophysis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002196 ! adenohypophysis +intersection_of: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis [Term] id: OBA:0003168 @@ -128553,7 +227905,7 @@ synonym: "opacity of skin of body" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000459 ! skin of body quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:0003169 @@ -128563,7 +227915,7 @@ synonym: "size of premaxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0002820 ! premaxillary bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002244 ! premaxilla +intersection_of: RO:0000052 UBERON:0002244 ! inheres in premaxilla [Term] id: OBA:0003170 @@ -128573,7 +227925,7 @@ synonym: "spatial pattern of epiphysis" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000131 ! long bone epiphysis morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003171 @@ -128582,8 +227934,8 @@ def: "The size of a anterior nasal spine of maxilla." [AUTO:patterns/patterns/en synonym: "size of anterior nasal spine of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0035139 ! anterior nasal spine of maxilla -relationship: inheres_in UBERON:0035139 ! anterior nasal spine of maxilla +intersection_of: RO:0000052 UBERON:0035139 ! inheres in anterior nasal spine of maxilla +relationship: RO:0000052 UBERON:0035139 ! inheres in anterior nasal spine of maxilla [Term] id: OBA:0003172 @@ -128593,7 +227945,7 @@ synonym: "rate of anagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000649 ! anagen quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042640 ! anagen +intersection_of: RO:0000052 GO:0042640 ! inheres in anagen [Term] id: OBA:0003173 @@ -128603,7 +227955,7 @@ synonym: "symmetry of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002102 ! ear morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:0003174 @@ -128613,7 +227965,7 @@ synonym: "altered number of of retina" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0001325 ! retina morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:0003175 @@ -128623,8 +227975,8 @@ synonym: "composition of pelvic complex" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0010709 ! pelvic complex -relationship: inheres_in UBERON:0010709 ! pelvic complex +intersection_of: RO:0000052 UBERON:0010709 ! inheres in pelvic complex +relationship: RO:0000052 UBERON:0010709 ! inheres in pelvic complex [Term] id: OBA:0003176 @@ -128634,8 +227986,8 @@ synonym: "composition of pectoral complex" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0010708 ! pectoral complex -relationship: inheres_in UBERON:0010708 ! pectoral complex +intersection_of: RO:0000052 UBERON:0010708 ! inheres in pectoral complex +relationship: RO:0000052 UBERON:0010708 ! inheres in pectoral complex [Term] id: OBA:0003177 @@ -128645,7 +227997,7 @@ synonym: "position of lacrimal punctum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000424 ! lacrimal punctum quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0010284 ! lacrimal punctum +intersection_of: RO:0000052 UBERON:0010284 ! inheres in lacrimal punctum [Term] id: OBA:0003178 @@ -128655,7 +228007,7 @@ synonym: "position of premaxilla" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003802 ! digestive system element position is_a: OBA:1000377 ! premaxilla quality intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002244 ! premaxilla +intersection_of: RO:0000052 UBERON:0002244 ! inheres in premaxilla [Term] id: OBA:0003179 @@ -128665,8 +228017,8 @@ synonym: "amount of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000314 ! pedal digit quality is_a: OBA:VT0003800 ! digit quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 -relationship: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 +relationship: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0003180 @@ -128676,7 +228028,7 @@ synonym: "size of bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000168 ! tracheal tube size is_a: OBA:VT0002264 ! bronchus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002185 ! bronchus +intersection_of: RO:0000052 UBERON:0002185 ! inheres in bronchus [Term] id: OBA:0003181 @@ -128686,7 +228038,7 @@ synonym: "size of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000168 ! tracheal tube size is_a: OBA:VT0002282 ! trachea morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0003182 @@ -128696,7 +228048,7 @@ synonym: "concavity of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000580 ! nail shape trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:0003183 @@ -128706,7 +228058,7 @@ synonym: "spatial pattern of upper lip" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003867 ! lip spatial pattern is_a: OBA:0005681 ! upper lip morphology intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0003184 @@ -128715,8 +228067,8 @@ def: "The position of a tongue." [AUTO:patterns/patterns/entity_attribute] synonym: "position of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001723 ! tongue -relationship: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue +relationship: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0003185 @@ -128725,8 +228077,8 @@ def: "The size of a palatine uvula." [AUTO:patterns/patterns/entity_attribute] synonym: "size of palatine uvula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001734 ! palatine uvula -relationship: inheres_in UBERON:0001734 ! palatine uvula +intersection_of: RO:0000052 UBERON:0001734 ! inheres in palatine uvula +relationship: RO:0000052 UBERON:0001734 ! inheres in palatine uvula [Term] id: OBA:0003186 @@ -128736,7 +228088,7 @@ synonym: "length of palatine uvula" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003185 ! palatine uvula size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001734 ! palatine uvula +intersection_of: RO:0000052 UBERON:0001734 ! inheres in palatine uvula [Term] id: OBA:0003187 @@ -128746,8 +228098,8 @@ synonym: "amount of whorl of hair" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0014381 ! whorl of hair -relationship: inheres_in UBERON:0014381 ! whorl of hair +intersection_of: RO:0000052 UBERON:0014381 ! inheres in whorl of hair +relationship: RO:0000052 UBERON:0014381 ! inheres in whorl of hair [Term] id: OBA:0003188 @@ -128757,8 +228109,8 @@ synonym: "occurrence of proprioception" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0015095 ! sensory trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0019230 ! proprioception -relationship: inheres_in GO:0019230 ! proprioception +intersection_of: RO:0000052 GO:0019230 ! inheres in proprioception +relationship: RO:0000052 GO:0019230 ! inheres in proprioception [Term] id: OBA:0003189 @@ -128768,7 +228120,7 @@ synonym: "closure of aortic valve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000040 ! aortic valve morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0003190 @@ -128778,8 +228130,8 @@ synonym: "shape of nucleobase metabolic process" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0009112 ! nucleobase metabolic process -relationship: inheres_in GO:0009112 ! nucleobase metabolic process +intersection_of: RO:0000052 GO:0009112 ! inheres in nucleobase metabolic process +relationship: RO:0000052 GO:0009112 ! inheres in nucleobase metabolic process [Term] id: OBA:0003191 @@ -128789,7 +228141,7 @@ synonym: "functionality of erythrocyte differentiation" EXACT [AUTO:patterns/pat is_a: OBA:VT0000245 ! erythropoiesis trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0030218 ! erythrocyte differentiation +intersection_of: RO:0000052 GO:0030218 ! inheres in erythrocyte differentiation [Term] id: OBA:0003192 @@ -128799,8 +228151,8 @@ synonym: "morphology of cerebral subcortex" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000454 ! cerebral subcortex -relationship: inheres_in UBERON:0000454 ! cerebral subcortex +intersection_of: RO:0000052 UBERON:0000454 ! inheres in cerebral subcortex +relationship: RO:0000052 UBERON:0000454 ! inheres in cerebral subcortex [Term] id: OBA:0003193 @@ -128810,8 +228162,8 @@ synonym: "amount of optic tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001908 ! optic tract -relationship: inheres_in UBERON:0001908 ! optic tract +intersection_of: RO:0000052 UBERON:0001908 ! inheres in optic tract +relationship: RO:0000052 UBERON:0001908 ! inheres in optic tract [Term] id: OBA:0003194 @@ -128821,7 +228173,7 @@ synonym: "functionality of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0003195 @@ -128831,8 +228183,8 @@ synonym: "rate of fructose metabolic process" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000452 ! carbohydrate metabolic process quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006000 ! fructose metabolic process -relationship: inheres_in GO:0006000 ! fructose metabolic process +intersection_of: RO:0000052 GO:0006000 ! inheres in fructose metabolic process +relationship: RO:0000052 GO:0006000 ! inheres in fructose metabolic process [Term] id: OBA:0003196 @@ -128842,8 +228194,8 @@ synonym: "amount of secondary dentition" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007774 ! secondary dentition -relationship: inheres_in UBERON:0007774 ! secondary dentition +intersection_of: RO:0000052 UBERON:0007774 ! inheres in secondary dentition +relationship: RO:0000052 UBERON:0007774 ! inheres in secondary dentition [Term] id: OBA:0003197 @@ -128852,8 +228204,8 @@ def: "The amount of a upper central secondary incisor tooth." [AUTO:patterns/pat synonym: "amount of upper central secondary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002701 ! upper central incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016454 ! upper central secondary incisor tooth -relationship: inheres_in UBERON:0016454 ! upper central secondary incisor tooth +intersection_of: RO:0000052 UBERON:0016454 ! inheres in upper central secondary incisor tooth +relationship: RO:0000052 UBERON:0016454 ! inheres in upper central secondary incisor tooth [Term] id: OBA:0003198 @@ -128862,8 +228214,8 @@ def: "The amount of a upper central primary incisor tooth." [AUTO:patterns/patte synonym: "amount of upper central primary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002701 ! upper central incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018593 ! upper central primary incisor tooth -relationship: inheres_in UBERON:0018593 ! upper central primary incisor tooth +intersection_of: RO:0000052 UBERON:0018593 ! inheres in upper central primary incisor tooth +relationship: RO:0000052 UBERON:0018593 ! inheres in upper central primary incisor tooth [Term] id: OBA:0003199 @@ -128872,8 +228224,8 @@ def: "The amount of a lower central primary incisor tooth." [AUTO:patterns/patte synonym: "amount of lower central primary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002711 ! lower central incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018595 ! lower central primary incisor tooth -relationship: inheres_in UBERON:0018595 ! lower central primary incisor tooth +intersection_of: RO:0000052 UBERON:0018595 ! inheres in lower central primary incisor tooth +relationship: RO:0000052 UBERON:0018595 ! inheres in lower central primary incisor tooth [Term] id: OBA:0003200 @@ -128882,8 +228234,8 @@ def: "The amount of a lower central secondary incisor tooth." [AUTO:patterns/pat synonym: "amount of lower central secondary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002711 ! lower central incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018568 ! lower central secondary incisor tooth -relationship: inheres_in UBERON:0018568 ! lower central secondary incisor tooth +intersection_of: RO:0000052 UBERON:0018568 ! inheres in lower central secondary incisor tooth +relationship: RO:0000052 UBERON:0018568 ! inheres in lower central secondary incisor tooth [Term] id: OBA:0003201 @@ -128892,8 +228244,8 @@ def: "The amount of a upper lateral primary incisor tooth." [AUTO:patterns/patte synonym: "amount of upper lateral primary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002135 ! upper lateral incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018594 ! upper lateral primary incisor tooth -relationship: inheres_in UBERON:0018594 ! upper lateral primary incisor tooth +intersection_of: RO:0000052 UBERON:0018594 ! inheres in upper lateral primary incisor tooth +relationship: RO:0000052 UBERON:0018594 ! inheres in upper lateral primary incisor tooth [Term] id: OBA:0003202 @@ -128902,8 +228254,8 @@ def: "The amount of a upper lateral secondary incisor tooth." [AUTO:patterns/pat synonym: "amount of upper lateral secondary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002135 ! upper lateral incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016455 ! upper lateral secondary incisor tooth -relationship: inheres_in UBERON:0016455 ! upper lateral secondary incisor tooth +intersection_of: RO:0000052 UBERON:0016455 ! inheres in upper lateral secondary incisor tooth +relationship: RO:0000052 UBERON:0016455 ! inheres in upper lateral secondary incisor tooth [Term] id: OBA:0003203 @@ -128913,7 +228265,7 @@ synonym: "amount of premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002130 ! calcareous tooth amount is_a: OBA:1000593 ! premolar tooth quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007120 ! premolar tooth +intersection_of: RO:0000052 UBERON:0007120 ! inheres in premolar tooth [Term] id: OBA:0003204 @@ -128922,8 +228274,8 @@ def: "The amount of a upper secondary premolar tooth." [AUTO:patterns/patterns/e synonym: "amount of upper secondary premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003203 ! premolar tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016452 ! upper secondary premolar tooth -relationship: inheres_in UBERON:0016452 ! upper secondary premolar tooth +intersection_of: RO:0000052 UBERON:0016452 ! inheres in upper secondary premolar tooth +relationship: RO:0000052 UBERON:0016452 ! inheres in upper secondary premolar tooth [Term] id: OBA:0003205 @@ -128932,8 +228284,8 @@ def: "The amount of a lower secondary premolar tooth." [AUTO:patterns/patterns/e synonym: "amount of lower secondary premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003203 ! premolar tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016453 ! lower secondary premolar tooth -relationship: inheres_in UBERON:0016453 ! lower secondary premolar tooth +intersection_of: RO:0000052 UBERON:0016453 ! inheres in lower secondary premolar tooth +relationship: RO:0000052 UBERON:0016453 ! inheres in lower secondary premolar tooth [Term] id: OBA:0003206 @@ -128943,7 +228295,7 @@ synonym: "amount of molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002130 ! calcareous tooth amount is_a: OBA:1000436 ! molar tooth quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:0003207 @@ -128952,8 +228304,8 @@ def: "The amount of a secondary molar tooth." [AUTO:patterns/patterns/entity_att synonym: "amount of secondary molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003206 ! molar tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0013618 ! secondary molar tooth -relationship: inheres_in UBERON:0013618 ! secondary molar tooth +intersection_of: RO:0000052 UBERON:0013618 ! inheres in secondary molar tooth +relationship: RO:0000052 UBERON:0013618 ! inheres in secondary molar tooth [Term] id: OBA:0003208 @@ -128962,8 +228314,8 @@ def: "The amount of a permanent molar tooth 1." [AUTO:patterns/patterns/entity_a synonym: "amount of permanent molar tooth 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003207 ! secondary molar tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018608 ! permanent molar tooth 1 -relationship: inheres_in UBERON:0018608 ! permanent molar tooth 1 +intersection_of: RO:0000052 UBERON:0018608 ! inheres in permanent molar tooth 1 +relationship: RO:0000052 UBERON:0018608 ! inheres in permanent molar tooth 1 [Term] id: OBA:0003209 @@ -128972,8 +228324,8 @@ def: "The amount of a permanent molar tooth 2." [AUTO:patterns/patterns/entity_a synonym: "amount of permanent molar tooth 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003207 ! secondary molar tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018607 ! permanent molar tooth 2 -relationship: inheres_in UBERON:0018607 ! permanent molar tooth 2 +intersection_of: RO:0000052 UBERON:0018607 ! inheres in permanent molar tooth 2 +relationship: RO:0000052 UBERON:0018607 ! inheres in permanent molar tooth 2 [Term] id: OBA:0003210 @@ -128983,7 +228335,7 @@ synonym: "structure of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0002100 ! tooth morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:0003211 @@ -128993,7 +228345,7 @@ synonym: "convex 3-D shape of incisor tooth" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0005358 ! incisor morphology trait is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0003212 @@ -129002,8 +228354,8 @@ def: "The morphology of a secondary molar tooth." [AUTO:patterns/patterns/entity synonym: "morphology of secondary molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002689 ! molar morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013618 ! secondary molar tooth -relationship: inheres_in UBERON:0013618 ! secondary molar tooth +intersection_of: RO:0000052 UBERON:0013618 ! inheres in secondary molar tooth +relationship: RO:0000052 UBERON:0013618 ! inheres in secondary molar tooth [Term] id: OBA:0003213 @@ -129013,7 +228365,7 @@ synonym: "altered number of of tooth root" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000486 ! tooth root quality is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0003677 ! tooth root +intersection_of: RO:0000052 UBERON:0003677 ! inheres in tooth root [Term] id: OBA:0003214 @@ -129023,7 +228375,7 @@ synonym: "color of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0002100 ! tooth morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:0003215 @@ -129033,7 +228385,7 @@ synonym: "morphology of premolar tooth" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000593 ! premolar tooth quality is_a: OBA:VT0002100 ! tooth morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007120 ! premolar tooth +intersection_of: RO:0000052 UBERON:0007120 ! inheres in premolar tooth [Term] id: OBA:0003216 @@ -129042,8 +228394,8 @@ def: "The convex 3-D shape of a primary incisor tooth." [AUTO:patterns/patterns/ synonym: "convex 3-D shape of primary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003211 ! incisor tooth convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0016476 ! primary incisor tooth -relationship: inheres_in UBERON:0016476 ! primary incisor tooth +intersection_of: RO:0000052 UBERON:0016476 ! inheres in primary incisor tooth +relationship: RO:0000052 UBERON:0016476 ! inheres in primary incisor tooth [Term] id: OBA:0003217 @@ -129052,8 +228404,8 @@ def: "The convex 3-D shape of a upper jaw incisor." [AUTO:patterns/patterns/enti synonym: "convex 3-D shape of upper jaw incisor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003211 ! incisor tooth convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in UBERON:0003450 ! upper jaw incisor -relationship: inheres_in UBERON:0003450 ! upper jaw incisor +intersection_of: RO:0000052 UBERON:0003450 ! inheres in upper jaw incisor +relationship: RO:0000052 UBERON:0003450 ! inheres in upper jaw incisor [Term] id: OBA:0003218 @@ -129063,8 +228415,8 @@ synonym: "amount of peripheral nervous system myelin maintenance" EXACT [AUTO:pa is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0032287 ! peripheral nervous system myelin maintenance -relationship: inheres_in GO:0032287 ! peripheral nervous system myelin maintenance +intersection_of: RO:0000052 GO:0032287 ! inheres in peripheral nervous system myelin maintenance +relationship: RO:0000052 GO:0032287 ! inheres in peripheral nervous system myelin maintenance [Term] id: OBA:0003219 @@ -129074,7 +228426,7 @@ synonym: "closure of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002581 ! ileum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:0003220 @@ -129084,7 +228436,7 @@ synonym: "amount of alimentary part of gastrointestinal system" EXACT [AUTO:patt is_a: OBA:1000149 ! alimentary part of gastrointestinal system quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0003221 @@ -129094,7 +228446,7 @@ synonym: "shape of occipital bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0005269 ! occipital bone morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:0003222 @@ -129104,7 +228456,7 @@ synonym: "shape of frontal cortex" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000798 ! frontal lobe morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001870 ! frontal cortex +intersection_of: RO:0000052 UBERON:0001870 ! inheres in frontal cortex [Term] id: OBA:0003223 @@ -129114,8 +228466,8 @@ synonym: "amount of antihelix" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016466 ! antihelix -relationship: inheres_in UBERON:0016466 ! antihelix +intersection_of: RO:0000052 UBERON:0016466 ! inheres in antihelix +relationship: RO:0000052 UBERON:0016466 ! inheres in antihelix [Term] id: OBA:0003224 @@ -129125,8 +228477,8 @@ synonym: "spatial pattern of antitragus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0016467 ! antitragus -relationship: inheres_in UBERON:0016467 ! antitragus +intersection_of: RO:0000052 UBERON:0016467 ! inheres in antitragus +relationship: RO:0000052 UBERON:0016467 ! inheres in antitragus [Term] id: OBA:0003225 @@ -129136,8 +228488,8 @@ synonym: "amount of antitragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0016467 ! antitragus -relationship: inheres_in UBERON:0016467 ! antitragus +intersection_of: RO:0000052 UBERON:0016467 ! inheres in antitragus +relationship: RO:0000052 UBERON:0016467 ! inheres in antitragus [Term] id: OBA:0003226 @@ -129147,8 +228499,8 @@ synonym: "concavity of antitragus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0016467 ! antitragus -relationship: inheres_in UBERON:0016467 ! antitragus +intersection_of: RO:0000052 UBERON:0016467 ! inheres in antitragus +relationship: RO:0000052 UBERON:0016467 ! inheres in antitragus [Term] id: OBA:0003227 @@ -129157,8 +228509,8 @@ def: "The size of a antitragus." [AUTO:patterns/patterns/entity_attribute] synonym: "size of antitragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0016467 ! antitragus -relationship: inheres_in UBERON:0016467 ! antitragus +intersection_of: RO:0000052 UBERON:0016467 ! inheres in antitragus +relationship: RO:0000052 UBERON:0016467 ! inheres in antitragus [Term] id: OBA:0003228 @@ -129168,7 +228520,7 @@ synonym: "concavity of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0003677 ! ear lobe morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:0003229 @@ -129178,8 +228530,8 @@ synonym: "amount of tragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010887 ! tragus -relationship: inheres_in UBERON:0010887 ! tragus +intersection_of: RO:0000052 UBERON:0010887 ! inheres in tragus +relationship: RO:0000052 UBERON:0010887 ! inheres in tragus [Term] id: OBA:0003230 @@ -129189,8 +228541,8 @@ synonym: "concavity of tragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0010887 ! tragus -relationship: inheres_in UBERON:0010887 ! tragus +intersection_of: RO:0000052 UBERON:0010887 ! inheres in tragus +relationship: RO:0000052 UBERON:0010887 ! inheres in tragus [Term] id: OBA:0003231 @@ -129200,8 +228552,8 @@ synonym: "position of tragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0010887 ! tragus -relationship: inheres_in UBERON:0010887 ! tragus +intersection_of: RO:0000052 UBERON:0010887 ! inheres in tragus +relationship: RO:0000052 UBERON:0010887 ! inheres in tragus [Term] id: OBA:0003232 @@ -129211,8 +228563,8 @@ synonym: "size of tragus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010887 ! tragus -relationship: inheres_in UBERON:0010887 ! tragus +intersection_of: RO:0000052 UBERON:0010887 ! inheres in tragus +relationship: RO:0000052 UBERON:0010887 ! inheres in tragus [Term] id: OBA:0003233 @@ -129222,7 +228574,7 @@ synonym: "size of distal segment of manual digit" EXACT [AUTO:patterns/patterns/ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000423 ! distal segment of manual digit quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009552 ! distal segment of manual digit +intersection_of: RO:0000052 UBERON:0009552 ! inheres in distal segment of manual digit [Term] id: OBA:0003234 @@ -129232,7 +228584,7 @@ synonym: "size of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002214 ! manual digit size is_a: OBA:0005188 ! manual digit 1 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0003235 @@ -129242,7 +228594,7 @@ synonym: "shape of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002192 ! digit shape is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0003236 @@ -129252,7 +228604,7 @@ synonym: "sharpness of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003235 ! pedal digit shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:0003237 @@ -129262,7 +228614,7 @@ synonym: "concavity of chin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003271 ! chin shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0008199 ! chin +intersection_of: RO:0000052 UBERON:0008199 ! inheres in chin [Term] id: OBA:0003238 @@ -129272,8 +228624,8 @@ synonym: "amount of internal ear" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001846 ! internal ear -relationship: inheres_in UBERON:0001846 ! internal ear +intersection_of: RO:0000052 UBERON:0001846 ! inheres in internal ear +relationship: RO:0000052 UBERON:0001846 ! inheres in internal ear [Term] id: OBA:0003239 @@ -129283,7 +228635,7 @@ synonym: "coiling of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000031 ! cochlea morphology trait is_a: PATO:0001794 ! coiling intersection_of: PATO:0001794 ! coiling -intersection_of: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:0003240 @@ -129293,8 +228645,8 @@ synonym: "amount of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001844 ! cochlea -relationship: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea +relationship: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:0003241 @@ -129304,8 +228656,8 @@ synonym: "morphology of osseus labyrinth vestibule" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005236 ! osseus labyrinth vestibule -relationship: inheres_in UBERON:0005236 ! osseus labyrinth vestibule +intersection_of: RO:0000052 UBERON:0005236 ! inheres in osseus labyrinth vestibule +relationship: RO:0000052 UBERON:0005236 ! inheres in osseus labyrinth vestibule [Term] id: OBA:0003242 @@ -129315,8 +228667,8 @@ synonym: "amount of osseus labyrinth vestibule" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005236 ! osseus labyrinth vestibule -relationship: inheres_in UBERON:0005236 ! osseus labyrinth vestibule +intersection_of: RO:0000052 UBERON:0005236 ! inheres in osseus labyrinth vestibule +relationship: RO:0000052 UBERON:0005236 ! inheres in osseus labyrinth vestibule [Term] id: OBA:0003243 @@ -129326,7 +228678,7 @@ synonym: "size of osseus labyrinth vestibule" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003241 ! osseus labyrinth vestibule morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005236 ! osseus labyrinth vestibule +intersection_of: RO:0000052 UBERON:0005236 ! inheres in osseus labyrinth vestibule [Term] id: OBA:0003244 @@ -129336,8 +228688,8 @@ synonym: "amount of semicircular canal" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001840 ! semicircular canal -relationship: inheres_in UBERON:0001840 ! semicircular canal +intersection_of: RO:0000052 UBERON:0001840 ! inheres in semicircular canal +relationship: RO:0000052 UBERON:0001840 ! inheres in semicircular canal [Term] id: OBA:0003245 @@ -129347,7 +228699,7 @@ synonym: "size of semicircular canal" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000172 ! tube size is_a: OBA:VT0002428 ! semicircular canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001840 ! semicircular canal +intersection_of: RO:0000052 UBERON:0001840 ! inheres in semicircular canal [Term] id: OBA:0003246 @@ -129357,7 +228709,7 @@ synonym: "amount of internal acoustic meatus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000453 ! internal acoustic meatus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011859 ! internal acoustic meatus +intersection_of: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus [Term] id: OBA:0003247 @@ -129367,7 +228719,7 @@ synonym: "circumference of internal acoustic meatus" EXACT [AUTO:patterns/patter is_a: OBA:0002543 ! internal acoustic meatus size is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0011859 ! internal acoustic meatus +intersection_of: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus [Term] id: OBA:0003248 @@ -129377,7 +228729,7 @@ synonym: "size of vestibular aqueduct" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000887 ! vestibular aqueduct quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002279 ! vestibular aqueduct +intersection_of: RO:0000052 UBERON:0002279 ! inheres in vestibular aqueduct [Term] id: OBA:0003249 @@ -129387,7 +228739,7 @@ synonym: "amount of vestibular nerve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000198 ! vestibular nerve quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003723 ! vestibular nerve +intersection_of: RO:0000052 UBERON:0003723 ! inheres in vestibular nerve [Term] id: OBA:0003250 @@ -129397,7 +228749,7 @@ synonym: "size of vestibular nerve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003316 ! nerve size is_a: OBA:0004054 ! vestibular nerve morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003723 ! vestibular nerve +intersection_of: RO:0000052 UBERON:0003723 ! inheres in vestibular nerve [Term] id: OBA:0003251 @@ -129407,7 +228759,7 @@ synonym: "onset quality of myelination in peripheral nervous system" EXACT [AUTO is_a: OBA:0003308 ! myelination onset quality is_a: OBA:1000558 ! myelination in peripheral nervous system quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0022011 ! myelination in peripheral nervous system +intersection_of: RO:0000052 GO:0022011 ! inheres in myelination in peripheral nervous system [Term] id: OBA:0003252 @@ -129417,7 +228769,7 @@ synonym: "composition of placenta" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0001711 ! placenta morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:0003253 @@ -129427,8 +228779,8 @@ synonym: "functionality of middle ear" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001756 ! middle ear -relationship: inheres_in UBERON:0001756 ! middle ear +intersection_of: RO:0000052 UBERON:0001756 ! inheres in middle ear +relationship: RO:0000052 UBERON:0001756 ! inheres in middle ear [Term] id: OBA:0003254 @@ -129438,7 +228790,7 @@ synonym: "amount of malleus bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000186 ! malleus bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001689 ! malleus bone +intersection_of: RO:0000052 UBERON:0001689 ! inheres in malleus bone [Term] id: OBA:0003255 @@ -129449,8 +228801,8 @@ is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:1000265 ! auditory ossicle bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001687 ! stapes bone -relationship: inheres_in UBERON:0001687 ! stapes bone +intersection_of: RO:0000052 UBERON:0001687 ! inheres in stapes bone +relationship: RO:0000052 UBERON:0001687 ! inheres in stapes bone [Term] id: OBA:0003256 @@ -129460,8 +228812,8 @@ synonym: "amount of gall bladder" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002110 ! gall bladder -relationship: inheres_in UBERON:0002110 ! gall bladder +intersection_of: RO:0000052 UBERON:0002110 ! inheres in gall bladder +relationship: RO:0000052 UBERON:0002110 ! inheres in gall bladder [Term] id: OBA:0003257 @@ -129471,8 +228823,8 @@ synonym: "morphology of intestinal villus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001213 ! intestinal villus -relationship: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus +relationship: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0003258 @@ -129482,7 +228834,7 @@ synonym: "size of intestinal villus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003257 ! intestinal villus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0003259 @@ -129492,7 +228844,7 @@ synonym: "shape of lens of camera-type eye" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0001303 ! lens morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:0003260 @@ -129503,8 +228855,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005116 ! chorda tendineae morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0014851 ! chorda tendinea of left ventricle -relationship: inheres_in UBERON:0014851 ! chorda tendinea of left ventricle +intersection_of: RO:0000052 UBERON:0014851 ! inheres in chorda tendinea of left ventricle +relationship: RO:0000052 UBERON:0014851 ! inheres in chorda tendinea of left ventricle [Term] id: OBA:0003261 @@ -129514,8 +228866,8 @@ synonym: "amount of pericardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002407 ! pericardium -relationship: inheres_in UBERON:0002407 ! pericardium +intersection_of: RO:0000052 UBERON:0002407 ! inheres in pericardium +relationship: RO:0000052 UBERON:0002407 ! inheres in pericardium [Term] id: OBA:0003262 @@ -129525,8 +228877,8 @@ synonym: "rhythm quality of heart contraction" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000078 ! rhythm quality intersection_of: PATO:0000078 ! rhythm quality -intersection_of: inheres_in GO:0060047 ! heart contraction -relationship: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction +relationship: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:0003263 @@ -129536,8 +228888,8 @@ synonym: "displaced of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000057 ! gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002369 ! adrenal gland -relationship: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland +relationship: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:0003264 @@ -129547,8 +228899,8 @@ synonym: "amount of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002369 ! adrenal gland -relationship: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland +relationship: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:0003265 @@ -129558,7 +228910,7 @@ synonym: "structure of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0004164 ! neurohypophysis morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:0003266 @@ -129568,7 +228920,7 @@ synonym: "displaced of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000426 ! neurohypophysis quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:0003267 @@ -129578,7 +228930,7 @@ synonym: "amount of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000426 ! neurohypophysis quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:0003268 @@ -129588,7 +228940,7 @@ synonym: "size of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004164 ! neurohypophysis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:0003269 @@ -129598,7 +228950,7 @@ synonym: "concavity of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002084 ! nose shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:0003270 @@ -129608,8 +228960,8 @@ synonym: "closure of palatal muscle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003692 ! muscle organ morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003682 ! palatal muscle -relationship: inheres_in UBERON:0003682 ! palatal muscle +intersection_of: RO:0000052 UBERON:0003682 ! inheres in palatal muscle +relationship: RO:0000052 UBERON:0003682 ! inheres in palatal muscle [Term] id: OBA:0003271 @@ -129619,8 +228971,8 @@ synonym: "shape of chin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0008199 ! chin -relationship: inheres_in UBERON:0008199 ! chin +intersection_of: RO:0000052 UBERON:0008199 ! inheres in chin +relationship: RO:0000052 UBERON:0008199 ! inheres in chin [Term] id: OBA:0003272 @@ -129630,7 +228982,7 @@ synonym: "length of metatarsal bone of digit 2" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004033 ! metatarsal bone length is_a: OBA:1000491 ! metatarsal bone of digit 2 quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003651 ! metatarsal bone of digit 2 +intersection_of: RO:0000052 UBERON:0003651 ! inheres in metatarsal bone of digit 2 [Term] id: OBA:0003273 @@ -129640,7 +228992,7 @@ synonym: "composition of chordate pharynx" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005753 ! chordate pharynx structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001042 ! chordate pharynx +intersection_of: RO:0000052 UBERON:0001042 ! inheres in chordate pharynx [Term] id: OBA:0003274 @@ -129650,8 +229002,8 @@ synonym: "morphology of bone collagen fibril" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011863 ! bone collagen fibril -relationship: inheres_in UBERON:0011863 ! bone collagen fibril +intersection_of: RO:0000052 UBERON:0011863 ! inheres in bone collagen fibril +relationship: RO:0000052 UBERON:0011863 ! inheres in bone collagen fibril [Term] id: OBA:0003275 @@ -129662,7 +229014,7 @@ is_a: OBA:0003276 ! platelet morphology is_a: OBA:VT0000237 ! blood cell quantity is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:0003276 @@ -129672,8 +229024,8 @@ synonym: "morphology of platelet" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:VT0002429 ! blood cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000233 ! platelet -relationship: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet +relationship: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:0003277 @@ -129683,7 +229035,7 @@ synonym: "volume of platelet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000056 ! cell volume is_a: OBA:VT0010457 ! platelet size trait intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:0003278 @@ -129693,7 +229045,7 @@ synonym: "length of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002261 ! pedal digit length is_a: OBA:0003361 ! pedal digit 5 size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003635 ! pedal digit 5 +intersection_of: RO:0000052 UBERON:0003635 ! inheres in pedal digit 5 [Term] id: OBA:0003279 @@ -129703,8 +229055,8 @@ synonym: "rate of mitochondrial proton-transporting ATP synthase complex" EXACT is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0005753 ! mitochondrial proton-transporting ATP synthase complex -relationship: inheres_in GO:0005753 ! mitochondrial proton-transporting ATP synthase complex +intersection_of: RO:0000052 GO:0005753 ! inheres in mitochondrial proton-transporting ATP synthase complex +relationship: RO:0000052 GO:0005753 ! inheres in mitochondrial proton-transporting ATP synthase complex [Term] id: OBA:0003280 @@ -129713,8 +229065,8 @@ def: "The displaced of a pedal digit 1." [AUTO:patterns/patterns/entity_attribut synonym: "displaced of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002811 ! pedal digit displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 -relationship: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 +relationship: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0003281 @@ -129724,7 +229076,7 @@ synonym: "length of proximal phalanx of pes" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002588 ! phalanx of pes length is_a: OBA:0003087 ! proximal phalanx of pes size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:0003282 @@ -129734,7 +229086,7 @@ synonym: "length of superior cerebellar peduncle of pons" EXACT [AUTO:patterns/p is_a: OBA:0002323 ! superior cerebellar peduncle of pons size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0007709 ! superior cerebellar peduncle of pons +intersection_of: RO:0000052 UBERON:0007709 ! inheres in superior cerebellar peduncle of pons [Term] id: OBA:0003283 @@ -129743,8 +229095,8 @@ def: "The size of a nail of pedal digit 5." [AUTO:patterns/patterns/entity_attri synonym: "size of nail of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002255 ! nail of pedal digit size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011282 ! nail of pedal digit 5 -relationship: inheres_in UBERON:0011282 ! nail of pedal digit 5 +intersection_of: RO:0000052 UBERON:0011282 ! inheres in nail of pedal digit 5 +relationship: RO:0000052 UBERON:0011282 ! inheres in nail of pedal digit 5 [Term] id: OBA:0003284 @@ -129754,8 +229106,8 @@ synonym: "occurrence of ductus venosus closure" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0061116 ! ductus venosus closure -relationship: inheres_in GO:0061116 ! ductus venosus closure +intersection_of: RO:0000052 GO:0061116 ! inheres in ductus venosus closure +relationship: RO:0000052 GO:0061116 ! inheres in ductus venosus closure [Term] id: OBA:0003285 @@ -129765,7 +229117,7 @@ synonym: "composition of substantia propria of cornea" EXACT [AUTO:patterns/patt is_a: OBA:VT0005300 ! corneal stroma morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:0003286 @@ -129775,8 +229127,8 @@ synonym: "size of skeletal muscle fiber" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0003399 ! skeletal muscle fiber size trait is_a: OBA:VT0004087 ! muscle cell morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0008002 ! skeletal muscle fiber -relationship: inheres_in CL:0008002 ! skeletal muscle fiber +intersection_of: RO:0000052 CL:0008002 ! inheres in skeletal muscle fiber +relationship: RO:0000052 CL:0008002 ! inheres in skeletal muscle fiber [Term] id: OBA:0003287 @@ -129786,7 +229138,7 @@ synonym: "shape of mitochondrion" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002821 ! mitochondrion morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0005739 ! mitochondrion +intersection_of: RO:0000052 GO:0005739 ! inheres in mitochondrion [Term] id: OBA:0003288 @@ -129795,8 +229147,8 @@ def: "The functionality of a exocrine pancreas." [AUTO:patterns/patterns/entity_ synonym: "functionality of exocrine pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000017 ! exocrine pancreas -relationship: inheres_in UBERON:0000017 ! exocrine pancreas +intersection_of: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas +relationship: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas [Term] id: OBA:0003289 @@ -129806,8 +229158,8 @@ synonym: "functionality of endocrine pancreas" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000016 ! endocrine pancreas -relationship: inheres_in UBERON:0000016 ! endocrine pancreas +intersection_of: RO:0000052 UBERON:0000016 ! inheres in endocrine pancreas +relationship: RO:0000052 UBERON:0000016 ! inheres in endocrine pancreas [Term] id: OBA:0003290 @@ -129817,8 +229169,8 @@ synonym: "amount of mitochondrion" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005739 ! mitochondrion -relationship: inheres_in GO:0005739 ! mitochondrion +intersection_of: RO:0000052 GO:0005739 ! inheres in mitochondrion +relationship: RO:0000052 GO:0005739 ! inheres in mitochondrion [Term] id: OBA:0003291 @@ -129828,7 +229180,7 @@ synonym: "size of pons" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000848 ! pons morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000988 ! pons +intersection_of: RO:0000052 UBERON:0000988 ! inheres in pons [Term] id: OBA:0003292 @@ -129838,8 +229190,8 @@ synonym: "amount of erythroid progenitor cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000038 ! erythroid progenitor cell -relationship: inheres_in CL:0000038 ! erythroid progenitor cell +intersection_of: RO:0000052 CL:0000038 ! inheres in erythroid progenitor cell +relationship: RO:0000052 CL:0000038 ! inheres in erythroid progenitor cell [Term] id: OBA:0003293 @@ -129849,8 +229201,8 @@ synonym: "cellular motility of sperm" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000722 ! gamete quality is_a: PATO:0001488 ! cellular motility intersection_of: PATO:0001488 ! cellular motility -intersection_of: inheres_in CL:0000019 ! sperm -relationship: inheres_in CL:0000019 ! sperm +intersection_of: RO:0000052 CL:0000019 ! inheres in sperm +relationship: RO:0000052 CL:0000019 ! inheres in sperm [Term] id: OBA:0003294 @@ -129862,8 +229214,8 @@ is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:1000866 ! blood cell quality is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000094 ! granulocyte -relationship: inheres_in CL:0000094 ! granulocyte +intersection_of: RO:0000052 CL:0000094 ! inheres in granulocyte +relationship: RO:0000052 CL:0000094 ! inheres in granulocyte [Term] id: OBA:0003295 @@ -129874,7 +229226,7 @@ is_a: OBA:0002879 ! muscle organ size is_a: OBA:1000637 ! levator palpebrae superioris quality is_a: OBA:VT0005247 ! extraocular muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001604 ! levator palpebrae superioris +intersection_of: RO:0000052 UBERON:0001604 ! inheres in levator palpebrae superioris [Term] id: OBA:0003296 @@ -129884,8 +229236,8 @@ synonym: "size of rectus extraocular muscle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0005247 ! extraocular muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006533 ! rectus extraocular muscle -relationship: inheres_in UBERON:0006533 ! rectus extraocular muscle +intersection_of: RO:0000052 UBERON:0006533 ! inheres in rectus extraocular muscle +relationship: RO:0000052 UBERON:0006533 ! inheres in rectus extraocular muscle [Term] id: OBA:0003297 @@ -129895,8 +229247,8 @@ synonym: "morphology of respiratory system epithelium" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004807 ! respiratory system epithelium -relationship: inheres_in UBERON:0004807 ! respiratory system epithelium +intersection_of: RO:0000052 UBERON:0004807 ! inheres in respiratory system epithelium +relationship: RO:0000052 UBERON:0004807 ! inheres in respiratory system epithelium [Term] id: OBA:0003298 @@ -129906,7 +229258,7 @@ synonym: "size of proximal epiphysis of tibia" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003163 ! epiphysis size is_a: OBA:1000148 ! proximal epiphysis of tibia quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008772 ! proximal epiphysis of tibia +intersection_of: RO:0000052 UBERON:0008772 ! inheres in proximal epiphysis of tibia [Term] id: OBA:0003299 @@ -129918,7 +229270,7 @@ is_a: OBA:1000382 ! middle phalanx of manus quality is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:0003300 @@ -129930,7 +229282,7 @@ is_a: OBA:1000190 ! distal phalanx of manus quality is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:0003301 @@ -129942,7 +229294,7 @@ is_a: OBA:1000610 ! proximal phalanx of manus quality is_a: OBA:VT0005306 ! phalanx morphology trait is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:0003302 @@ -129952,7 +229304,7 @@ synonym: "curvature of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002280 ! face shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:0003303 @@ -129962,7 +229314,7 @@ synonym: "position of jugal bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000316 ! jugal bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001683 ! jugal bone +intersection_of: RO:0000052 UBERON:0001683 ! inheres in jugal bone [Term] id: OBA:0003304 @@ -129972,7 +229324,7 @@ synonym: "position of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000496 ! midface quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003305 @@ -129982,8 +229334,8 @@ synonym: "rate of carnitine O-palmitoyltransferase activity" EXACT [AUTO:pattern is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004095 ! carnitine O-palmitoyltransferase activity -relationship: inheres_in GO:0004095 ! carnitine O-palmitoyltransferase activity +intersection_of: RO:0000052 GO:0004095 ! inheres in carnitine O-palmitoyltransferase activity +relationship: RO:0000052 GO:0004095 ! inheres in carnitine O-palmitoyltransferase activity [Term] id: OBA:0003306 @@ -129993,8 +229345,8 @@ synonym: "position of calcaneus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000508 ! tarsal bone quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001450 ! calcaneus -relationship: inheres_in UBERON:0001450 ! calcaneus +intersection_of: RO:0000052 UBERON:0001450 ! inheres in calcaneus +relationship: RO:0000052 UBERON:0001450 ! inheres in calcaneus [Term] id: OBA:0003307 @@ -130004,7 +229356,7 @@ synonym: "functionality of biliary tree" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000184 ! biliary tree quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001173 ! biliary tree +intersection_of: RO:0000052 UBERON:0001173 ! inheres in biliary tree [Term] id: OBA:0003308 @@ -130014,7 +229366,7 @@ synonym: "onset quality of myelination" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000920 ! myelination trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0042552 ! myelination +intersection_of: RO:0000052 GO:0042552 ! inheres in myelination [Term] id: OBA:0003309 @@ -130023,8 +229375,8 @@ def: "The strength of a orbicularis oculi muscle." [AUTO:patterns/patterns/entit synonym: "strength of orbicularis oculi muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003852 ! eye muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001578 ! orbicularis oculi muscle -relationship: inheres_in UBERON:0001578 ! orbicularis oculi muscle +intersection_of: RO:0000052 UBERON:0001578 ! inheres in orbicularis oculi muscle +relationship: RO:0000052 UBERON:0001578 ! inheres in orbicularis oculi muscle [Term] id: OBA:0003310 @@ -130034,7 +229386,7 @@ synonym: "rate of catalase activity" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0005697 ! peroxidase activity rate is_a: OBA:1000650 ! catalase activity quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004096 ! catalase activity +intersection_of: RO:0000052 GO:0004096 ! inheres in catalase activity [Term] id: OBA:0003311 @@ -130043,8 +229395,8 @@ def: "The size of a nail of manual digit 1." [AUTO:patterns/patterns/entity_attr synonym: "size of nail of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002257 ! nail of manual digit size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011273 ! nail of manual digit 1 -relationship: inheres_in UBERON:0011273 ! nail of manual digit 1 +intersection_of: RO:0000052 UBERON:0011273 ! inheres in nail of manual digit 1 +relationship: RO:0000052 UBERON:0011273 ! inheres in nail of manual digit 1 [Term] id: OBA:0003312 @@ -130053,8 +229405,8 @@ def: "The amount of a nail of manual digit 1." [AUTO:patterns/patterns/entity_at synonym: "amount of nail of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002259 ! nail of manual digit amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011273 ! nail of manual digit 1 -relationship: inheres_in UBERON:0011273 ! nail of manual digit 1 +intersection_of: RO:0000052 UBERON:0011273 ! inheres in nail of manual digit 1 +relationship: RO:0000052 UBERON:0011273 ! inheres in nail of manual digit 1 [Term] id: OBA:0003313 @@ -130063,8 +229415,8 @@ def: "The amount of a nail of pedal digit 1." [AUTO:patterns/patterns/entity_att synonym: "amount of nail of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002256 ! nail of pedal digit amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011278 ! nail of pedal digit 1 -relationship: inheres_in UBERON:0011278 ! nail of pedal digit 1 +intersection_of: RO:0000052 UBERON:0011278 ! inheres in nail of pedal digit 1 +relationship: RO:0000052 UBERON:0011278 ! inheres in nail of pedal digit 1 [Term] id: OBA:0003314 @@ -130073,8 +229425,8 @@ def: "The composition of a lower eyelid." [AUTO:patterns/patterns/entity_attribu synonym: "composition of lower eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003388 ! eyelid composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001713 ! lower eyelid -relationship: inheres_in UBERON:0001713 ! lower eyelid +intersection_of: RO:0000052 UBERON:0001713 ! inheres in lower eyelid +relationship: RO:0000052 UBERON:0001713 ! inheres in lower eyelid [Term] id: OBA:0003315 @@ -130084,8 +229436,8 @@ synonym: "onset quality of menarche" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0042696 ! menarche -relationship: inheres_in GO:0042696 ! menarche +intersection_of: RO:0000052 GO:0042696 ! inheres in menarche +relationship: RO:0000052 GO:0042696 ! inheres in menarche [Term] id: OBA:0003316 @@ -130095,7 +229447,7 @@ synonym: "size of nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001021 ! nerve +intersection_of: RO:0000052 UBERON:0001021 ! inheres in nerve [Term] id: OBA:0003317 @@ -130105,8 +229457,8 @@ synonym: "rate of inflammatory response" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006954 ! inflammatory response -relationship: inheres_in GO:0006954 ! inflammatory response +intersection_of: RO:0000052 GO:0006954 ! inheres in inflammatory response +relationship: RO:0000052 GO:0006954 ! inheres in inflammatory response [Term] id: OBA:0003318 @@ -130116,7 +229468,7 @@ synonym: "composition of pineal body" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003319 ! pineal body structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0003319 @@ -130126,7 +229478,7 @@ synonym: "structure of pineal body" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0000632 ! pineal gland morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0003320 @@ -130136,7 +229488,7 @@ synonym: "volume of pineal body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003321 ! pineal body size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0003321 @@ -130146,7 +229498,7 @@ synonym: "size of pineal body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000632 ! pineal gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0003322 @@ -130155,8 +229507,8 @@ def: "The functionality of a pineal body." [AUTO:patterns/patterns/entity_attrib synonym: "functionality of pineal body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005872 ! neuroendocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001905 ! pineal body -relationship: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body +relationship: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0003323 @@ -130166,7 +229518,7 @@ synonym: "size of dorsal thalamus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1000640 ! dorsal thalamus quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004703 ! dorsal thalamus +intersection_of: RO:0000052 UBERON:0004703 ! inheres in dorsal thalamus [Term] id: OBA:0003324 @@ -130176,7 +229528,7 @@ synonym: "morphology of alimentary part of gastrointestinal system" EXACT [AUTO: is_a: OBA:1000149 ! alimentary part of gastrointestinal system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0003325 @@ -130186,7 +229538,7 @@ synonym: "functionality of alimentary part of gastrointestinal system" EXACT [AU is_a: OBA:1000149 ! alimentary part of gastrointestinal system quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:0003326 @@ -130195,8 +229547,8 @@ def: "The composition of a upper eyelid." [AUTO:patterns/patterns/entity_attribu synonym: "composition of upper eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003388 ! eyelid composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001712 ! upper eyelid -relationship: inheres_in UBERON:0001712 ! upper eyelid +intersection_of: RO:0000052 UBERON:0001712 ! inheres in upper eyelid +relationship: RO:0000052 UBERON:0001712 ! inheres in upper eyelid [Term] id: OBA:0003327 @@ -130206,7 +229558,7 @@ synonym: "displaced of adenohypophysis" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000303 ! adenohypophysis quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002196 ! adenohypophysis +intersection_of: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis [Term] id: OBA:0003328 @@ -130216,7 +229568,7 @@ synonym: "amount of cuspid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002130 ! calcareous tooth amount is_a: OBA:1000335 ! cuspid quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003674 ! cuspid +intersection_of: RO:0000052 UBERON:0003674 ! inheres in cuspid [Term] id: OBA:0003329 @@ -130226,7 +229578,7 @@ synonym: "amount of mastoid process of temporal bone" EXACT [AUTO:patterns/patte is_a: OBA:1000402 ! mastoid process of temporal bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011220 ! mastoid process of temporal bone +intersection_of: RO:0000052 UBERON:0011220 ! inheres in mastoid process of temporal bone [Term] id: OBA:0003330 @@ -130236,7 +229588,7 @@ synonym: "size of calcaneus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002265 ! calcaneus morphology is_a: OBA:0002564 ! tarsal bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001450 ! calcaneus +intersection_of: RO:0000052 UBERON:0001450 ! inheres in calcaneus [Term] id: OBA:0003331 @@ -130246,7 +229598,7 @@ synonym: "size of external female genitalia" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002407 ! external genitalia size is_a: OBA:0003774 ! external female genitalia morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005056 ! external female genitalia +intersection_of: RO:0000052 UBERON:0005056 ! inheres in external female genitalia [Term] id: OBA:0003332 @@ -130256,8 +229608,8 @@ synonym: "contractility of small intestine" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0002108 ! small intestine -relationship: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine +relationship: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:0003333 @@ -130266,8 +229618,8 @@ def: "The morphology of a male germ cell." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of male germ cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002208 ! germ cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000015 ! male germ cell -relationship: inheres_in CL:0000015 ! male germ cell +intersection_of: RO:0000052 CL:0000015 ! inheres in male germ cell +relationship: RO:0000052 CL:0000015 ! inheres in male germ cell [Term] id: OBA:0003334 @@ -130276,8 +229628,8 @@ def: "The size of a facial muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "size of facial muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001577 ! facial muscle -relationship: inheres_in UBERON:0001577 ! facial muscle +intersection_of: RO:0000052 UBERON:0001577 ! inheres in facial muscle +relationship: RO:0000052 UBERON:0001577 ! inheres in facial muscle [Term] id: OBA:0003335 @@ -130286,8 +229638,8 @@ def: "The size of a scapular muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "size of scapular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0034908 ! scapular muscle -relationship: inheres_in UBERON:0034908 ! scapular muscle +intersection_of: RO:0000052 UBERON:0034908 ! inheres in scapular muscle +relationship: RO:0000052 UBERON:0034908 ! inheres in scapular muscle [Term] id: OBA:0003336 @@ -130297,7 +229649,7 @@ synonym: "closure of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001340 ! eyelid morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0003337 @@ -130307,7 +229659,7 @@ synonym: "amount of uterine cervix" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000174 ! uterine cervix quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000002 ! uterine cervix +intersection_of: RO:0000052 UBERON:0000002 ! inheres in uterine cervix [Term] id: OBA:0003338 @@ -130317,7 +229669,7 @@ synonym: "concavity of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000534 ! ureter morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0003339 @@ -130327,7 +229679,7 @@ synonym: "deviation of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002110 ! digit morphology trait is_a: PATO:0002175 ! deviation intersection_of: PATO:0002175 ! deviation -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:0003340 @@ -130337,7 +229689,7 @@ synonym: "size of renal glomerulus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004141 ! renal glomerulus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000074 ! renal glomerulus +intersection_of: RO:0000052 UBERON:0000074 ! inheres in renal glomerulus [Term] id: OBA:0003341 @@ -130347,7 +229699,7 @@ synonym: "amount of myelination in peripheral nervous system" EXACT [AUTO:patter is_a: OBA:1000558 ! myelination in peripheral nervous system quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0022011 ! myelination in peripheral nervous system +intersection_of: RO:0000052 GO:0022011 ! inheres in myelination in peripheral nervous system [Term] id: OBA:0003342 @@ -130356,8 +229708,8 @@ def: "The size of a deltoid." [AUTO:patterns/patterns/entity_attribute] synonym: "size of deltoid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003335 ! scapular muscle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001476 ! deltoid -relationship: inheres_in UBERON:0001476 ! deltoid +intersection_of: RO:0000052 UBERON:0001476 ! inheres in deltoid +relationship: RO:0000052 UBERON:0001476 ! inheres in deltoid [Term] id: OBA:0003343 @@ -130367,7 +229719,7 @@ synonym: "curvature of superior cerebellar peduncle of pons" EXACT [AUTO:pattern is_a: OBA:1000408 ! superior cerebellar peduncle of pons quality is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0007709 ! superior cerebellar peduncle of pons +intersection_of: RO:0000052 UBERON:0007709 ! inheres in superior cerebellar peduncle of pons [Term] id: OBA:0003344 @@ -130377,7 +229729,7 @@ synonym: "shape of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001312 ! cornea morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0003345 @@ -130387,8 +229739,8 @@ synonym: "position of coccyx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001350 ! coccyx -relationship: inheres_in UBERON:0001350 ! coccyx +intersection_of: RO:0000052 UBERON:0001350 ! inheres in coccyx +relationship: RO:0000052 UBERON:0001350 ! inheres in coccyx [Term] id: OBA:0003346 @@ -130397,8 +229749,8 @@ def: "The size of a upper eyelid." [AUTO:patterns/patterns/entity_attribute] synonym: "size of upper eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003431 ! eyelid size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001712 ! upper eyelid -relationship: inheres_in UBERON:0001712 ! upper eyelid +intersection_of: RO:0000052 UBERON:0001712 ! inheres in upper eyelid +relationship: RO:0000052 UBERON:0001712 ! inheres in upper eyelid [Term] id: OBA:0003347 @@ -130408,8 +229760,8 @@ synonym: "composition of macula lutea" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000053 ! macula lutea -relationship: inheres_in UBERON:0000053 ! macula lutea +intersection_of: RO:0000052 UBERON:0000053 ! inheres in macula lutea +relationship: RO:0000052 UBERON:0000053 ! inheres in macula lutea [Term] id: OBA:0003348 @@ -130419,8 +229771,8 @@ synonym: "spatial pattern of upper eyelash" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002126 ! eyelash spatial pattern is_a: OBA:0002302 ! hair of head spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0019254 ! upper eyelash -relationship: inheres_in UBERON:0019254 ! upper eyelash +intersection_of: RO:0000052 UBERON:0019254 ! inheres in upper eyelash +relationship: RO:0000052 UBERON:0019254 ! inheres in upper eyelash [Term] id: OBA:0003349 @@ -130430,8 +229782,8 @@ synonym: "length of lower eyelash" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002110 ! eyelash length is_a: OBA:1000405 ! hair of head quality intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0019255 ! lower eyelash -relationship: inheres_in UBERON:0019255 ! lower eyelash +intersection_of: RO:0000052 UBERON:0019255 ! inheres in lower eyelash +relationship: RO:0000052 UBERON:0019255 ! inheres in lower eyelash [Term] id: OBA:0003350 @@ -130441,8 +229793,8 @@ synonym: "amount of upper eyelash" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002114 ! eyelash amount is_a: OBA:0002330 ! strand of hair of face amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0019254 ! upper eyelash -relationship: inheres_in UBERON:0019254 ! upper eyelash +intersection_of: RO:0000052 UBERON:0019254 ! inheres in upper eyelash +relationship: RO:0000052 UBERON:0019254 ! inheres in upper eyelash [Term] id: OBA:0003351 @@ -130452,7 +229804,7 @@ synonym: "shape of radius bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0000552 ! radius morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:0003352 @@ -130461,8 +229813,8 @@ def: "The amount of a lymphocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000542 ! lymphocyte -relationship: inheres_in CL:0000542 ! lymphocyte +intersection_of: RO:0000052 CL:0000542 ! inheres in lymphocyte +relationship: RO:0000052 CL:0000542 ! inheres in lymphocyte [Term] id: OBA:0003353 @@ -130472,7 +229824,7 @@ synonym: "amount of natural killer cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003352 ! lymphocyte amount is_a: OBA:1000559 ! natural killer cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000623 ! natural killer cell +intersection_of: RO:0000052 CL:0000623 ! inheres in natural killer cell [Term] id: OBA:0003354 @@ -130482,7 +229834,7 @@ synonym: "degeneration of striatum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0004077 ! striatum morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002435 ! striatum +intersection_of: RO:0000052 UBERON:0002435 ! inheres in striatum [Term] id: OBA:0003355 @@ -130492,8 +229844,8 @@ synonym: "rate of 5-oxoprolinase (ATP-hydrolyzing) activity" EXACT [AUTO:pattern is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0017168 ! 5-oxoprolinase (ATP-hydrolyzing) activity -relationship: inheres_in GO:0017168 ! 5-oxoprolinase (ATP-hydrolyzing) activity +intersection_of: RO:0000052 GO:0017168 ! inheres in 5-oxoprolinase (ATP-hydrolyzing) activity +relationship: RO:0000052 GO:0017168 ! inheres in 5-oxoprolinase (ATP-hydrolyzing) activity [Term] id: OBA:0003356 @@ -130502,8 +229854,8 @@ def: "The morphology of a pelvic girdle bone/zone." [AUTO:patterns/patterns/enti synonym: "morphology of pelvic girdle bone/zone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003695 ! bone of appendage girdle complex morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007830 ! pelvic girdle bone/zone -relationship: inheres_in UBERON:0007830 ! pelvic girdle bone/zone +intersection_of: RO:0000052 UBERON:0007830 ! inheres in pelvic girdle bone/zone +relationship: RO:0000052 UBERON:0007830 ! inheres in pelvic girdle bone/zone [Term] id: OBA:0003357 @@ -130513,8 +229865,8 @@ synonym: "displaced of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000057 ! gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002046 ! thyroid gland -relationship: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland +relationship: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:0003358 @@ -130524,7 +229876,7 @@ synonym: "size of pedal digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:1000191 ! pedal digit 2 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003632 ! pedal digit 2 +intersection_of: RO:0000052 UBERON:0003632 ! inheres in pedal digit 2 [Term] id: OBA:0003359 @@ -130534,7 +229886,7 @@ synonym: "size of pedal digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:1000446 ! pedal digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003633 ! pedal digit 3 +intersection_of: RO:0000052 UBERON:0003633 ! inheres in pedal digit 3 [Term] id: OBA:0003360 @@ -130544,7 +229896,7 @@ synonym: "size of pedal digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:1000269 ! pedal digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003634 ! pedal digit 4 +intersection_of: RO:0000052 UBERON:0003634 ! inheres in pedal digit 4 [Term] id: OBA:0003361 @@ -130554,7 +229906,7 @@ synonym: "size of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002262 ! pedal digit size is_a: OBA:1000297 ! pedal digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003635 ! pedal digit 5 +intersection_of: RO:0000052 UBERON:0003635 ! inheres in pedal digit 5 [Term] id: OBA:0003362 @@ -130564,7 +229916,7 @@ synonym: "wholeness of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002344 ! epiphysis structure is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:0003363 @@ -130574,8 +229926,8 @@ synonym: "composition of musculature" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001015 ! musculature -relationship: inheres_in UBERON:0001015 ! musculature +intersection_of: RO:0000052 UBERON:0001015 ! inheres in musculature +relationship: RO:0000052 UBERON:0001015 ! inheres in musculature [Term] id: OBA:0003364 @@ -130585,8 +229937,8 @@ synonym: "composition of meningeal cluster" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0010743 ! meningeal cluster -relationship: inheres_in UBERON:0010743 ! meningeal cluster +intersection_of: RO:0000052 UBERON:0010743 ! inheres in meningeal cluster +relationship: RO:0000052 UBERON:0010743 ! inheres in meningeal cluster [Term] id: OBA:0003365 @@ -130596,7 +229948,7 @@ synonym: "structure of metaphysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000133 ! long bone metaphysis morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:0003366 @@ -130607,7 +229959,7 @@ is_a: OBA:0003079 ! distal phalanx of pes size is_a: OBA:0003115 ! pedal digit 3 phalanx size is_a: OBA:1000328 ! distal phalanx of pedal digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004317 ! distal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004317 ! inheres in distal phalanx of pedal digit 3 [Term] id: OBA:0003367 @@ -130618,7 +229970,7 @@ is_a: OBA:0003079 ! distal phalanx of pes size is_a: OBA:0003119 ! pedal digit 4 phalanx size is_a: OBA:1000468 ! distal phalanx of pedal digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004318 ! distal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004318 ! inheres in distal phalanx of pedal digit 4 [Term] id: OBA:0003368 @@ -130629,7 +229981,7 @@ is_a: OBA:0003079 ! distal phalanx of pes size is_a: OBA:0003123 ! pedal digit 5 phalanx size is_a: OBA:1000283 ! distal phalanx of pedal digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004319 ! distal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004319 ! inheres in distal phalanx of pedal digit 5 [Term] id: OBA:0003369 @@ -130640,7 +229992,7 @@ is_a: OBA:0003083 ! middle phalanx of pes size is_a: OBA:0003115 ! pedal digit 3 phalanx size is_a: OBA:1000419 ! middle phalanx of pedal digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004325 ! middle phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004325 ! inheres in middle phalanx of pedal digit 3 [Term] id: OBA:0003370 @@ -130651,7 +230003,7 @@ is_a: OBA:0003083 ! middle phalanx of pes size is_a: OBA:0003119 ! pedal digit 4 phalanx size is_a: OBA:1000299 ! middle phalanx of pedal digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004326 ! middle phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004326 ! inheres in middle phalanx of pedal digit 4 [Term] id: OBA:0003371 @@ -130662,7 +230014,7 @@ is_a: OBA:0003083 ! middle phalanx of pes size is_a: OBA:0003123 ! pedal digit 5 phalanx size is_a: OBA:1000175 ! middle phalanx of pedal digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004327 ! middle phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004327 ! inheres in middle phalanx of pedal digit 5 [Term] id: OBA:0003372 @@ -130673,7 +230025,7 @@ is_a: OBA:0003087 ! proximal phalanx of pes size is_a: OBA:0003115 ! pedal digit 3 phalanx size is_a: OBA:1000422 ! proximal phalanx of pedal digit 3 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004334 ! proximal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004334 ! inheres in proximal phalanx of pedal digit 3 [Term] id: OBA:0003373 @@ -130684,7 +230036,7 @@ is_a: OBA:0003087 ! proximal phalanx of pes size is_a: OBA:0003119 ! pedal digit 4 phalanx size is_a: OBA:1000215 ! proximal phalanx of pedal digit 4 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004335 ! proximal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004335 ! inheres in proximal phalanx of pedal digit 4 [Term] id: OBA:0003374 @@ -130695,7 +230047,7 @@ is_a: OBA:0003087 ! proximal phalanx of pes size is_a: OBA:0003123 ! pedal digit 5 phalanx size is_a: OBA:1000240 ! proximal phalanx of pedal digit 5 quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004336 ! proximal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004336 ! inheres in proximal phalanx of pedal digit 5 [Term] id: OBA:0003375 @@ -130706,7 +230058,7 @@ is_a: OBA:0003085 ! middle phalanx of pes curvature is_a: OBA:0003117 ! pedal digit 3 phalanx curvature is_a: OBA:1000419 ! middle phalanx of pedal digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004325 ! middle phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004325 ! inheres in middle phalanx of pedal digit 3 [Term] id: OBA:0003376 @@ -130717,7 +230069,7 @@ is_a: OBA:0003085 ! middle phalanx of pes curvature is_a: OBA:0003121 ! pedal digit 4 phalanx curvature is_a: OBA:1000299 ! middle phalanx of pedal digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004326 ! middle phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004326 ! inheres in middle phalanx of pedal digit 4 [Term] id: OBA:0003377 @@ -130728,7 +230080,7 @@ is_a: OBA:0003085 ! middle phalanx of pes curvature is_a: OBA:0003125 ! pedal digit 5 phalanx curvature is_a: OBA:1000175 ! middle phalanx of pedal digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004327 ! middle phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004327 ! inheres in middle phalanx of pedal digit 5 [Term] id: OBA:0003378 @@ -130739,7 +230091,7 @@ is_a: OBA:0003089 ! proximal phalanx of pes curvature is_a: OBA:0003117 ! pedal digit 3 phalanx curvature is_a: OBA:1000422 ! proximal phalanx of pedal digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004334 ! proximal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004334 ! inheres in proximal phalanx of pedal digit 3 [Term] id: OBA:0003379 @@ -130750,7 +230102,7 @@ is_a: OBA:0003089 ! proximal phalanx of pes curvature is_a: OBA:0003121 ! pedal digit 4 phalanx curvature is_a: OBA:1000215 ! proximal phalanx of pedal digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004335 ! proximal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004335 ! inheres in proximal phalanx of pedal digit 4 [Term] id: OBA:0003380 @@ -130761,7 +230113,7 @@ is_a: OBA:0003089 ! proximal phalanx of pes curvature is_a: OBA:0003125 ! pedal digit 5 phalanx curvature is_a: OBA:1000240 ! proximal phalanx of pedal digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004336 ! proximal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004336 ! inheres in proximal phalanx of pedal digit 5 [Term] id: OBA:0003381 @@ -130772,7 +230124,7 @@ is_a: OBA:0003081 ! distal phalanx of pes curvature is_a: OBA:0003117 ! pedal digit 3 phalanx curvature is_a: OBA:1000328 ! distal phalanx of pedal digit 3 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004317 ! distal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004317 ! inheres in distal phalanx of pedal digit 3 [Term] id: OBA:0003382 @@ -130783,7 +230135,7 @@ is_a: OBA:0003081 ! distal phalanx of pes curvature is_a: OBA:0003121 ! pedal digit 4 phalanx curvature is_a: OBA:1000468 ! distal phalanx of pedal digit 4 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004318 ! distal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004318 ! inheres in distal phalanx of pedal digit 4 [Term] id: OBA:0003383 @@ -130794,7 +230146,7 @@ is_a: OBA:0003081 ! distal phalanx of pes curvature is_a: OBA:0003125 ! pedal digit 5 phalanx curvature is_a: OBA:1000283 ! distal phalanx of pedal digit 5 quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004319 ! distal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004319 ! inheres in distal phalanx of pedal digit 5 [Term] id: OBA:0003384 @@ -130805,7 +230157,7 @@ is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000179 ! mast cell quality is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:0003385 @@ -130815,7 +230167,7 @@ synonym: "amount of micturition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000368 ! micturition quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060073 ! micturition +intersection_of: RO:0000052 GO:0060073 ! inheres in micturition [Term] id: OBA:0003386 @@ -130825,8 +230177,8 @@ synonym: "amount of appendage girdle complex" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010707 ! appendage girdle complex -relationship: inheres_in UBERON:0010707 ! appendage girdle complex +intersection_of: RO:0000052 UBERON:0010707 ! inheres in appendage girdle complex +relationship: RO:0000052 UBERON:0010707 ! inheres in appendage girdle complex [Term] id: OBA:0003387 @@ -130836,7 +230188,7 @@ synonym: "composition of periorbital region" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000566 ! periorbital region quality is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0004090 ! periorbital region +intersection_of: RO:0000052 UBERON:0004090 ! inheres in periorbital region [Term] id: OBA:0003388 @@ -130846,7 +230198,7 @@ synonym: "composition of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001340 ! eyelid morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0003389 @@ -130856,7 +230208,7 @@ synonym: "structure of artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003463 ! blood vessel structure is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001637 ! artery +intersection_of: RO:0000052 UBERON:0001637 ! inheres in artery [Term] id: OBA:0003390 @@ -130866,7 +230218,7 @@ synonym: "symmetry of growth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in GO:0040007 ! growth +intersection_of: RO:0000052 GO:0040007 ! inheres in growth [Term] id: OBA:0003391 @@ -130876,7 +230228,7 @@ synonym: "composition of cartilage element" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002355 ! cartilage element morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0007844 ! cartilage element +intersection_of: RO:0000052 UBERON:0007844 ! inheres in cartilage element [Term] id: OBA:0003392 @@ -130886,7 +230238,7 @@ synonym: "composition of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001175 ! lung morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:0003393 @@ -130896,8 +230248,8 @@ synonym: "morphology of trabecular network of bone" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008867 ! trabecular network of bone -relationship: inheres_in UBERON:0008867 ! trabecular network of bone +intersection_of: RO:0000052 UBERON:0008867 ! inheres in trabecular network of bone +relationship: RO:0000052 UBERON:0008867 ! inheres in trabecular network of bone [Term] id: OBA:0003394 @@ -130907,8 +230259,8 @@ synonym: "position of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000996 ! vagina -relationship: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina +relationship: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0003395 @@ -130918,7 +230270,7 @@ synonym: "rotated of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000558 ! tibia morphology trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:0003396 @@ -130928,7 +230280,7 @@ synonym: "structure of multicellular organism" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003397 @@ -130939,7 +230291,7 @@ is_a: OBA:VT0000953 ! oligodendrocyte morphology trait is_a: OBA:VT0003647 ! oligodendrocyte quantity is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:0003398 @@ -130949,7 +230301,7 @@ synonym: "composition of muscle organ" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003692 ! muscle organ morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0003399 @@ -130958,8 +230310,8 @@ def: "The structure of a nail of pedal digit." [AUTO:patterns/patterns/entity_at synonym: "structure of nail of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002297 ! nail structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0009567 ! nail of pedal digit -relationship: inheres_in UBERON:0009567 ! nail of pedal digit +intersection_of: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit +relationship: RO:0000052 UBERON:0009567 ! inheres in nail of pedal digit [Term] id: OBA:0003400 @@ -130969,7 +230321,7 @@ synonym: "size of areola" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010609 ! areola morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002032 ! areola +intersection_of: RO:0000052 UBERON:0002032 ! inheres in areola [Term] id: OBA:0003401 @@ -130979,8 +230331,8 @@ synonym: "size of triceps brachii" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003335 ! scapular muscle size is_a: OBA:VT0010647 ! forelimb muscle morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001509 ! triceps brachii -relationship: inheres_in UBERON:0001509 ! triceps brachii +intersection_of: RO:0000052 UBERON:0001509 ! inheres in triceps brachii +relationship: RO:0000052 UBERON:0001509 ! inheres in triceps brachii [Term] id: OBA:0003402 @@ -130990,7 +230342,7 @@ synonym: "size of celiac artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002341 ! abdominal aorta artery size is_a: OBA:0005971 ! celiac artery morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001640 ! celiac artery +intersection_of: RO:0000052 UBERON:0001640 ! inheres in celiac artery [Term] id: OBA:0003403 @@ -130999,8 +230351,8 @@ def: "The size of a superior mesenteric artery." [AUTO:patterns/patterns/entity_ synonym: "size of superior mesenteric artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002341 ! abdominal aorta artery size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001182 ! superior mesenteric artery -relationship: inheres_in UBERON:0001182 ! superior mesenteric artery +intersection_of: RO:0000052 UBERON:0001182 ! inheres in superior mesenteric artery +relationship: RO:0000052 UBERON:0001182 ! inheres in superior mesenteric artery [Term] id: OBA:0003404 @@ -131009,8 +230361,8 @@ def: "The size of a inferior mesenteric artery." [AUTO:patterns/patterns/entity_ synonym: "size of inferior mesenteric artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002341 ! abdominal aorta artery size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001183 ! inferior mesenteric artery -relationship: inheres_in UBERON:0001183 ! inferior mesenteric artery +intersection_of: RO:0000052 UBERON:0001183 ! inheres in inferior mesenteric artery +relationship: RO:0000052 UBERON:0001183 ! inheres in inferior mesenteric artery [Term] id: OBA:0003405 @@ -131020,8 +230372,8 @@ synonym: "amount of head of femur" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006767 ! head of femur -relationship: inheres_in UBERON:0006767 ! head of femur +intersection_of: RO:0000052 UBERON:0006767 ! inheres in head of femur +relationship: RO:0000052 UBERON:0006767 ! inheres in head of femur [Term] id: OBA:0003406 @@ -131031,8 +230383,8 @@ synonym: "amount of neck of femur" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007119 ! neck of femur -relationship: inheres_in UBERON:0007119 ! neck of femur +intersection_of: RO:0000052 UBERON:0007119 ! inheres in neck of femur +relationship: RO:0000052 UBERON:0007119 ! inheres in neck of femur [Term] id: OBA:0003407 @@ -131042,7 +230394,7 @@ synonym: "height of ilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002162 ! ilium size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001273 ! ilium +intersection_of: RO:0000052 UBERON:0001273 ! inheres in ilium [Term] id: OBA:0003408 @@ -131052,7 +230404,7 @@ synonym: "structure of duodenum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003271 ! duodenum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002114 ! duodenum +intersection_of: RO:0000052 UBERON:0002114 ! inheres in duodenum [Term] id: OBA:0003409 @@ -131062,7 +230414,7 @@ synonym: "concavity of xiphoid process" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000159 ! xiphoid process morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0002207 ! xiphoid process +intersection_of: RO:0000052 UBERON:0002207 ! inheres in xiphoid process [Term] id: OBA:0003410 @@ -131072,7 +230424,7 @@ synonym: "position of xiphoid process" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000594 ! xiphoid process quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002207 ! xiphoid process +intersection_of: RO:0000052 UBERON:0002207 ! inheres in xiphoid process [Term] id: OBA:0003411 @@ -131082,7 +230434,7 @@ synonym: "size of xiphoid process" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000159 ! xiphoid process morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002207 ! xiphoid process +intersection_of: RO:0000052 UBERON:0002207 ! inheres in xiphoid process [Term] id: OBA:0003412 @@ -131092,8 +230444,8 @@ synonym: "closure of operculum of brain" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0010262 ! operculum of brain -relationship: inheres_in UBERON:0010262 ! operculum of brain +intersection_of: RO:0000052 UBERON:0010262 ! inheres in operculum of brain +relationship: RO:0000052 UBERON:0010262 ! inheres in operculum of brain [Term] id: OBA:0003413 @@ -131103,7 +230455,7 @@ synonym: "size of Ammon's horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000815 ! Ammon gyrus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001954 ! Ammon's horn +intersection_of: RO:0000052 UBERON:0001954 ! inheres in Ammon's horn [Term] id: OBA:0003414 @@ -131113,7 +230465,7 @@ synonym: "length of corpus callosum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000781 ! corpus callosum size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002336 ! corpus callosum +intersection_of: RO:0000052 UBERON:0002336 ! inheres in corpus callosum [Term] id: OBA:0003415 @@ -131123,8 +230475,8 @@ synonym: "shape of shoulder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001467 ! shoulder -relationship: inheres_in UBERON:0001467 ! shoulder +intersection_of: RO:0000052 UBERON:0001467 ! inheres in shoulder +relationship: RO:0000052 UBERON:0001467 ! inheres in shoulder [Term] id: OBA:0003416 @@ -131134,7 +230486,7 @@ synonym: "duration of penile erection" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000794 ! penile erection quality is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in GO:0043084 ! penile erection +intersection_of: RO:0000052 GO:0043084 ! inheres in penile erection [Term] id: OBA:0003417 @@ -131144,8 +230496,8 @@ synonym: "onset quality of sister chromatid segregation" EXACT [AUTO:patterns/pa is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0000819 ! sister chromatid segregation -relationship: inheres_in GO:0000819 ! sister chromatid segregation +intersection_of: RO:0000052 GO:0000819 ! inheres in sister chromatid segregation +relationship: RO:0000052 GO:0000819 ! inheres in sister chromatid segregation [Term] id: OBA:0003418 @@ -131154,8 +230506,8 @@ def: "The amount of a nail of manual digit 5." [AUTO:patterns/patterns/entity_at synonym: "amount of nail of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002259 ! nail of manual digit amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011277 ! nail of manual digit 5 -relationship: inheres_in UBERON:0011277 ! nail of manual digit 5 +intersection_of: RO:0000052 UBERON:0011277 ! inheres in nail of manual digit 5 +relationship: RO:0000052 UBERON:0011277 ! inheres in nail of manual digit 5 [Term] id: OBA:0003419 @@ -131164,8 +230516,8 @@ def: "The amount of a nail of pedal digit 5." [AUTO:patterns/patterns/entity_att synonym: "amount of nail of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002256 ! nail of pedal digit amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011282 ! nail of pedal digit 5 -relationship: inheres_in UBERON:0011282 ! nail of pedal digit 5 +intersection_of: RO:0000052 UBERON:0011282 ! inheres in nail of pedal digit 5 +relationship: RO:0000052 UBERON:0011282 ! inheres in nail of pedal digit 5 [Term] id: OBA:0003420 @@ -131174,8 +230526,8 @@ def: "The amount of a lateral incisor tooth." [AUTO:patterns/patterns/entity_att synonym: "amount of lateral incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002731 ! incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018552 ! lateral incisor tooth -relationship: inheres_in UBERON:0018552 ! lateral incisor tooth +intersection_of: RO:0000052 UBERON:0018552 ! inheres in lateral incisor tooth +relationship: RO:0000052 UBERON:0018552 ! inheres in lateral incisor tooth [Term] id: OBA:0003421 @@ -131185,8 +230537,8 @@ synonym: "amount of lower lateral incisor tooth" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003420 ! lateral incisor tooth amount is_a: OBA:0003425 ! lower jaw incisor amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018602 ! lower lateral incisor tooth -relationship: inheres_in UBERON:0018602 ! lower lateral incisor tooth +intersection_of: RO:0000052 UBERON:0018602 ! inheres in lower lateral incisor tooth +relationship: RO:0000052 UBERON:0018602 ! inheres in lower lateral incisor tooth [Term] id: OBA:0003422 @@ -131195,8 +230547,8 @@ def: "The amount of a lower lateral secondary incisor tooth." [AUTO:patterns/pat synonym: "amount of lower lateral secondary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003421 ! lower lateral incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018570 ! lower lateral secondary incisor tooth -relationship: inheres_in UBERON:0018570 ! lower lateral secondary incisor tooth +intersection_of: RO:0000052 UBERON:0018570 ! inheres in lower lateral secondary incisor tooth +relationship: RO:0000052 UBERON:0018570 ! inheres in lower lateral secondary incisor tooth [Term] id: OBA:0003423 @@ -131205,8 +230557,8 @@ def: "The amount of a lower lateral primary incisor tooth." [AUTO:patterns/patte synonym: "amount of lower lateral primary incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003421 ! lower lateral incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018596 ! lower lateral primary incisor tooth -relationship: inheres_in UBERON:0018596 ! lower lateral primary incisor tooth +intersection_of: RO:0000052 UBERON:0018596 ! inheres in lower lateral primary incisor tooth +relationship: RO:0000052 UBERON:0018596 ! inheres in lower lateral primary incisor tooth [Term] id: OBA:0003424 @@ -131215,8 +230567,8 @@ def: "The amount of a upper jaw incisor." [AUTO:patterns/patterns/entity_attribu synonym: "amount of upper jaw incisor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002731 ! incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003450 ! upper jaw incisor -relationship: inheres_in UBERON:0003450 ! upper jaw incisor +intersection_of: RO:0000052 UBERON:0003450 ! inheres in upper jaw incisor +relationship: RO:0000052 UBERON:0003450 ! inheres in upper jaw incisor [Term] id: OBA:0003425 @@ -131225,8 +230577,8 @@ def: "The amount of a lower jaw incisor." [AUTO:patterns/patterns/entity_attribu synonym: "amount of lower jaw incisor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002731 ! incisor tooth amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003451 ! lower jaw incisor -relationship: inheres_in UBERON:0003451 ! lower jaw incisor +intersection_of: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor +relationship: RO:0000052 UBERON:0003451 ! inheres in lower jaw incisor [Term] id: OBA:0003426 @@ -131236,7 +230588,7 @@ synonym: "length of external ear" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000017 ! outer ear size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0003427 @@ -131246,7 +230598,7 @@ synonym: "closure of primary palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000832 ! primary palate quality is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0005620 ! primary palate +intersection_of: RO:0000052 UBERON:0005620 ! inheres in primary palate [Term] id: OBA:0003428 @@ -131256,7 +230608,7 @@ synonym: "closure of hard palate" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0003756 ! hard palate morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003216 ! hard palate +intersection_of: RO:0000052 UBERON:0003216 ! inheres in hard palate [Term] id: OBA:0003429 @@ -131266,8 +230618,8 @@ synonym: "displaced of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001702 ! eyelash -relationship: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash +relationship: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:0003430 @@ -131277,8 +230629,8 @@ synonym: "amount of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001711 ! eyelid -relationship: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid +relationship: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0003431 @@ -131288,7 +230640,7 @@ synonym: "size of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001340 ! eyelid morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0003432 @@ -131298,8 +230650,8 @@ synonym: "morphology of inner ear epithelium" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006937 ! inner ear epithelium -relationship: inheres_in UBERON:0006937 ! inner ear epithelium +intersection_of: RO:0000052 UBERON:0006937 ! inheres in inner ear epithelium +relationship: RO:0000052 UBERON:0006937 ! inheres in inner ear epithelium [Term] id: OBA:0003433 @@ -131309,7 +230661,7 @@ synonym: "texture of external ear" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002845 ! external ear morphology is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0003434 @@ -131319,7 +230671,7 @@ synonym: "prominence of external ear" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002077 ! external ear position is_a: PATO:0015007 ! prominence intersection_of: PATO:0015007 ! prominence -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0003435 @@ -131329,8 +230681,8 @@ synonym: "amount of scala media" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002295 ! scala media -relationship: inheres_in UBERON:0002295 ! scala media +intersection_of: RO:0000052 UBERON:0002295 ! inheres in scala media +relationship: RO:0000052 UBERON:0002295 ! inheres in scala media [Term] id: OBA:0003436 @@ -131341,8 +230693,8 @@ is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0000039 ! otic capsule morphology trait is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005411 ! bony otic capsule -relationship: inheres_in UBERON:0005411 ! bony otic capsule +intersection_of: RO:0000052 UBERON:0005411 ! inheres in bony otic capsule +relationship: RO:0000052 UBERON:0005411 ! inheres in bony otic capsule [Term] id: OBA:0003437 @@ -131352,7 +230704,7 @@ synonym: "degeneration of spiral organ of cochlea" EXACT [AUTO:patterns/patterns is_a: OBA:VT0000042 ! organ of Corti morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002227 ! spiral organ of cochlea +intersection_of: RO:0000052 UBERON:0002227 ! inheres in spiral organ of cochlea [Term] id: OBA:0003438 @@ -131361,8 +230713,8 @@ def: "The onset quality of a outer ear unfolding." [AUTO:patterns/patterns/entit synonym: "onset quality of outer ear unfolding" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060185 ! outer ear unfolding -relationship: inheres_in GO:0060185 ! outer ear unfolding +intersection_of: RO:0000052 GO:0060185 ! inheres in outer ear unfolding +relationship: RO:0000052 GO:0060185 ! inheres in outer ear unfolding [Term] id: OBA:0003439 @@ -131372,18 +230724,17 @@ synonym: "size of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002102 ! ear morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:0003440 name: outer ear emergence onset quality def: "The onset quality of a outer ear emergence." [AUTO:patterns/patterns/entity_attribute] synonym: "onset quality of outer ear emergence" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:0002216 ! growth onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060186 ! outer ear emergence -relationship: inheres_in GO:0060186 ! outer ear emergence +intersection_of: RO:0000052 GO:0060186 ! inheres in outer ear emergence +relationship: RO:0000052 GO:0060186 ! inheres in outer ear emergence [Term] id: OBA:0003441 @@ -131393,7 +230744,7 @@ synonym: "onset quality of ossification" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000057 ! ossification trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001503 ! ossification +intersection_of: RO:0000052 GO:0001503 ! inheres in ossification [Term] id: OBA:0003442 @@ -131403,7 +230754,7 @@ synonym: "fragility of skeletal system" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004155 ! skeletal system morphology is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0001434 ! skeletal system +intersection_of: RO:0000052 UBERON:0001434 ! inheres in skeletal system [Term] id: OBA:0003443 @@ -131413,7 +230764,7 @@ synonym: "size of axial skeleton plus cranial skeleton" EXACT [AUTO:patterns/pat is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003694 ! axial skeleton plus cranial skeleton morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005944 ! axial skeleton plus cranial skeleton +intersection_of: RO:0000052 UBERON:0005944 ! inheres in axial skeleton plus cranial skeleton [Term] id: OBA:0003444 @@ -131423,7 +230774,7 @@ synonym: "onset quality of cranial suture" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002205 ! skeletal joint onset quality is_a: OBA:1000211 ! cranial suture quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in UBERON:0003685 ! cranial suture +intersection_of: RO:0000052 UBERON:0003685 ! inheres in cranial suture [Term] id: OBA:0003445 @@ -131433,7 +230784,7 @@ synonym: "length of mandible" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002072 ! mandible size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0003446 @@ -131443,7 +230794,7 @@ synonym: "length of premaxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003169 ! premaxilla size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002244 ! premaxilla +intersection_of: RO:0000052 UBERON:0002244 ! inheres in premaxilla [Term] id: OBA:0003447 @@ -131453,7 +230804,7 @@ synonym: "length of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002068 ! maxilla size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002397 ! maxilla +intersection_of: RO:0000052 UBERON:0002397 ! inheres in maxilla [Term] id: OBA:0003448 @@ -131463,8 +230814,8 @@ synonym: "amount of tooth placode" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005087 ! tooth placode -relationship: inheres_in UBERON:0005087 ! tooth placode +intersection_of: RO:0000052 UBERON:0005087 ! inheres in tooth placode +relationship: RO:0000052 UBERON:0005087 ! inheres in tooth placode [Term] id: OBA:0003449 @@ -131474,7 +230825,7 @@ synonym: "occurrence of odontogenesis" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000116 ! tooth development trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0042476 ! odontogenesis +intersection_of: RO:0000052 GO:0042476 ! inheres in odontogenesis [Term] id: OBA:0003450 @@ -131484,7 +230835,7 @@ synonym: "onset quality of tooth eruption" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0000119 ! tooth eruption trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0044691 ! tooth eruption +intersection_of: RO:0000052 GO:0044691 ! inheres in tooth eruption [Term] id: OBA:0003451 @@ -131494,7 +230845,7 @@ synonym: "fragility of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003210 ! calcareous tooth structure is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:0003452 @@ -131505,7 +230856,7 @@ is_a: OBA:0003210 ! calcareous tooth structure is_a: OBA:VT0002689 ! molar morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:0003453 @@ -131515,7 +230866,7 @@ synonym: "growth quality of occurrent of molar tooth" EXACT [AUTO:patterns/patte is_a: OBA:1000436 ! molar tooth quality is_a: PATO:0001433 ! growth quality of occurrent intersection_of: PATO:0001433 ! growth quality of occurrent -intersection_of: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:0003454 @@ -131525,7 +230876,7 @@ synonym: "degeneration of ameloblast" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003725 ! ameloblast morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000059 ! ameloblast +intersection_of: RO:0000052 CL:0000059 ! inheres in ameloblast [Term] id: OBA:0003455 @@ -131535,7 +230886,7 @@ synonym: "branchiness of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003157 ! rib shape is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0003457 @@ -131545,8 +230896,8 @@ synonym: "amount of chondrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000138 ! chondrocyte -relationship: inheres_in CL:0000138 ! chondrocyte +intersection_of: RO:0000052 CL:0000138 ! inheres in chondrocyte +relationship: RO:0000052 CL:0000138 ! inheres in chondrocyte [Term] id: OBA:0003458 @@ -131556,7 +230907,7 @@ synonym: "amount of bone marrow cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000764 ! bone marrow cell quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002092 ! bone marrow cell +intersection_of: RO:0000052 CL:0002092 ! inheres in bone marrow cell [Term] id: OBA:0003459 @@ -131567,7 +230918,7 @@ is_a: OBA:0004495 ! erythroid progenitor cell morphology is_a: OBA:VT0000237 ! blood cell quantity is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0000038 ! erythroid progenitor cell +intersection_of: RO:0000052 CL:0000038 ! inheres in erythroid progenitor cell [Term] id: OBA:0003460 @@ -131577,7 +230928,7 @@ synonym: "volume of erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000056 ! cell volume is_a: OBA:VT0000248 ! erythrocyte size trait intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:0003461 @@ -131587,7 +230938,7 @@ synonym: "rate of blood circulation" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000258 ! blood circulation quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008015 ! blood circulation +intersection_of: RO:0000052 GO:0008015 ! inheres in blood circulation [Term] id: OBA:0003462 @@ -131597,7 +230948,7 @@ synonym: "rate of fertilization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005410 ! fertilization trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0009566 ! fertilization +intersection_of: RO:0000052 GO:0009566 ! inheres in fertilization [Term] id: OBA:0003463 @@ -131607,7 +230958,7 @@ synonym: "structure of blood vessel" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0001614 ! blood vessel morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:0003464 @@ -131617,7 +230968,7 @@ synonym: "surface feature shape of erythrocyte" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0002641 ! erythrocyte shape trait is_a: PATO:0001925 ! surface feature shape intersection_of: PATO:0001925 ! surface feature shape -intersection_of: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:0003465 @@ -131627,8 +230978,8 @@ synonym: "organization quality of vascular system" EXACT [AUTO:patterns/patterns is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0007798 ! vascular system -relationship: inheres_in UBERON:0007798 ! vascular system +intersection_of: RO:0000052 UBERON:0007798 ! inheres in vascular system +relationship: RO:0000052 UBERON:0007798 ! inheres in vascular system [Term] id: OBA:0003466 @@ -131638,8 +230989,8 @@ synonym: "amount of branching involved in blood vessel morphogenesis" EXACT [AUT is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001569 ! branching involved in blood vessel morphogenesis -relationship: inheres_in GO:0001569 ! branching involved in blood vessel morphogenesis +intersection_of: RO:0000052 GO:0001569 ! inheres in branching involved in blood vessel morphogenesis +relationship: RO:0000052 GO:0001569 ! inheres in branching involved in blood vessel morphogenesis [Term] id: OBA:0003467 @@ -131649,7 +231000,7 @@ synonym: "closure of blood vessel" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0001614 ! blood vessel morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:0003468 @@ -131658,8 +231009,8 @@ def: "The size of a heart ventricle wall." [AUTO:patterns/patterns/entity_attrib synonym: "size of heart ventricle wall" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004784 ! heart ventricle wall -relationship: inheres_in UBERON:0004784 ! heart ventricle wall +intersection_of: RO:0000052 UBERON:0004784 ! inheres in heart ventricle wall +relationship: RO:0000052 UBERON:0004784 ! inheres in heart ventricle wall [Term] id: OBA:0003469 @@ -131669,8 +231020,8 @@ synonym: "morphology of cardial valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000946 ! cardial valve -relationship: inheres_in UBERON:0000946 ! cardial valve +intersection_of: RO:0000052 UBERON:0000946 ! inheres in cardial valve +relationship: RO:0000052 UBERON:0000946 ! inheres in cardial valve [Term] id: OBA:0003470 @@ -131680,7 +231031,7 @@ synonym: "size of cardial valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000946 ! cardial valve +intersection_of: RO:0000052 UBERON:0000946 ! inheres in cardial valve [Term] id: OBA:0003471 @@ -131690,7 +231041,7 @@ synonym: "size of pericardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000288 ! pericardium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002407 ! pericardium +intersection_of: RO:0000052 UBERON:0002407 ! inheres in pericardium [Term] id: OBA:0003472 @@ -131699,8 +231050,8 @@ def: "The size of a parietal serous pericardium." [AUTO:patterns/patterns/entity synonym: "size of parietal serous pericardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002408 ! parietal serous pericardium -relationship: inheres_in UBERON:0002408 ! parietal serous pericardium +intersection_of: RO:0000052 UBERON:0002408 ! inheres in parietal serous pericardium +relationship: RO:0000052 UBERON:0002408 ! inheres in parietal serous pericardium [Term] id: OBA:0003473 @@ -131710,7 +231061,7 @@ synonym: "size of trabecula carnea" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003907 ! trabecula carnea morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002511 ! trabecula carnea +intersection_of: RO:0000052 UBERON:0002511 ! inheres in trabecula carnea [Term] id: OBA:0003474 @@ -131720,8 +231071,8 @@ synonym: "amount of trabecula carnea" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002511 ! trabecula carnea -relationship: inheres_in UBERON:0002511 ! trabecula carnea +intersection_of: RO:0000052 UBERON:0002511 ! inheres in trabecula carnea +relationship: RO:0000052 UBERON:0002511 ! inheres in trabecula carnea [Term] id: OBA:0003475 @@ -131731,8 +231082,8 @@ synonym: "amount of endocardial cushion" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002062 ! endocardial cushion -relationship: inheres_in UBERON:0002062 ! endocardial cushion +intersection_of: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion +relationship: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion [Term] id: OBA:0003476 @@ -131742,8 +231093,8 @@ synonym: "amount of necrotic cell death" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0070265 ! necrotic cell death -relationship: inheres_in GO:0070265 ! necrotic cell death +intersection_of: RO:0000052 GO:0070265 ! inheres in necrotic cell death +relationship: RO:0000052 GO:0070265 ! inheres in necrotic cell death [Term] id: OBA:0003477 @@ -131753,8 +231104,8 @@ synonym: "amount of enterocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000584 ! enterocyte -relationship: inheres_in CL:0000584 ! enterocyte +intersection_of: RO:0000052 CL:0000584 ! inheres in enterocyte +relationship: RO:0000052 CL:0000584 ! inheres in enterocyte [Term] id: OBA:0003478 @@ -131764,7 +231115,7 @@ synonym: "color of corpora quadrigemina" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000899 ! corpora quadrigemina morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0002259 ! corpora quadrigemina +intersection_of: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina [Term] id: OBA:0003479 @@ -131774,8 +231125,8 @@ synonym: "rate of cell population proliferation" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008283 ! cell population proliferation -relationship: inheres_in GO:0008283 ! cell population proliferation +intersection_of: RO:0000052 GO:0008283 ! inheres in cell population proliferation +relationship: RO:0000052 GO:0008283 ! inheres in cell population proliferation [Term] id: OBA:0003480 @@ -131785,7 +231136,7 @@ synonym: "structure of hair follicle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0002076 ! hair follicle morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:0003481 @@ -131795,8 +231146,8 @@ synonym: "amount of hair follicle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002073 ! hair follicle -relationship: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle +relationship: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:0003482 @@ -131806,8 +231157,8 @@ synonym: "position of hair follicle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002073 ! hair follicle -relationship: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle +relationship: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:0003483 @@ -131817,7 +231168,7 @@ synonym: "onset quality of hair follicle development" EXACT [AUTO:patterns/patte is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0003704 ! hair follicle development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001942 ! hair follicle development +intersection_of: RO:0000052 GO:0001942 ! inheres in hair follicle development [Term] id: OBA:0003484 @@ -131827,7 +231178,7 @@ synonym: "rate of catagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000721 ! catagen quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042637 ! catagen +intersection_of: RO:0000052 GO:0042637 ! inheres in catagen [Term] id: OBA:0003485 @@ -131837,8 +231188,8 @@ synonym: "occurrence of hair follicle morphogenesis" EXACT [AUTO:patterns/patter is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0031069 ! hair follicle morphogenesis -relationship: inheres_in GO:0031069 ! hair follicle morphogenesis +intersection_of: RO:0000052 GO:0031069 ! inheres in hair follicle morphogenesis +relationship: RO:0000052 GO:0031069 ! inheres in hair follicle morphogenesis [Term] id: OBA:0003486 @@ -131848,7 +231199,7 @@ synonym: "curvature of strand of hair" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003493 ! strand of hair shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0003487 @@ -131858,7 +231209,7 @@ synonym: "shape of strand of guard hair" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003493 ! strand of hair shape is_a: OBA:1000934 ! strand of guard hair quality intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0010512 ! strand of guard hair +intersection_of: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair [Term] id: OBA:0003488 @@ -131868,7 +231219,7 @@ synonym: "curvature of strand of guard hair" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003486 ! strand of hair curvature is_a: OBA:0003487 ! strand of guard hair shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0010512 ! strand of guard hair +intersection_of: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair [Term] id: OBA:0003489 @@ -131878,7 +231229,7 @@ synonym: "curvature of strand of awl hair" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003486 ! strand of hair curvature is_a: OBA:1000674 ! strand of awl hair quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0010511 ! strand of awl hair +intersection_of: RO:0000052 UBERON:0010511 ! inheres in strand of awl hair [Term] id: OBA:0003490 @@ -131888,7 +231239,7 @@ synonym: "curvature of strand of zigzag hair" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003486 ! strand of hair curvature is_a: OBA:1000813 ! strand of zigzag hair quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0010513 ! strand of zigzag hair +intersection_of: RO:0000052 UBERON:0010513 ! inheres in strand of zigzag hair [Term] id: OBA:0003491 @@ -131898,7 +231249,7 @@ synonym: "curvature of strand of auchene hair" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003486 ! strand of hair curvature is_a: OBA:1000665 ! strand of auchene hair quality intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0010510 ! strand of auchene hair +intersection_of: RO:0000052 UBERON:0010510 ! inheres in strand of auchene hair [Term] id: OBA:0003492 @@ -131908,7 +231259,7 @@ synonym: "amount of strand of duvet hair" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000881 ! strand of duvet hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010514 ! strand of duvet hair +intersection_of: RO:0000052 UBERON:0010514 ! inheres in strand of duvet hair [Term] id: OBA:0003493 @@ -131918,7 +231269,7 @@ synonym: "shape of strand of hair" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0003494 @@ -131928,7 +231279,7 @@ synonym: "color saturation of strand of hair" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0003495 @@ -131938,7 +231289,7 @@ synonym: "onset quality of anagen" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000649 ! anagen quality is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0042640 ! anagen +intersection_of: RO:0000052 GO:0042640 ! inheres in anagen [Term] id: OBA:0003496 @@ -131948,7 +231299,7 @@ synonym: "displaced of anagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000649 ! anagen quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in GO:0042640 ! anagen +intersection_of: RO:0000052 GO:0042640 ! inheres in anagen [Term] id: OBA:0003497 @@ -131958,8 +231309,8 @@ synonym: "amount of palatine bone horizontal plate" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0018242 ! palatine bone horizontal plate -relationship: inheres_in UBERON:0018242 ! palatine bone horizontal plate +intersection_of: RO:0000052 UBERON:0018242 ! inheres in palatine bone horizontal plate +relationship: RO:0000052 UBERON:0018242 ! inheres in palatine bone horizontal plate [Term] id: OBA:0003498 @@ -131969,7 +231320,7 @@ synonym: "curvature of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010612 ! cranium morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:0003499 @@ -131979,7 +231330,7 @@ synonym: "morphology of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000496 ! midface quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003500 @@ -131990,7 +231341,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003499 ! midface morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003501 @@ -132000,7 +231351,7 @@ synonym: "curvature of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003499 ! midface morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003502 @@ -132010,7 +231361,7 @@ synonym: "sharpness of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003499 ! midface morphology is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003503 @@ -132020,7 +231371,7 @@ synonym: "texture of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003499 ! midface morphology is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0003504 @@ -132030,8 +231381,8 @@ synonym: "morphology of mandible" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001684 ! mandible -relationship: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible +relationship: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0003505 @@ -132040,8 +231391,8 @@ def: "The size of a skeleton of lower jaw." [AUTO:patterns/patterns/entity_attri synonym: "size of skeleton of lower jaw" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003278 ! skeleton of lower jaw -relationship: inheres_in UBERON:0003278 ! skeleton of lower jaw +intersection_of: RO:0000052 UBERON:0003278 ! inheres in skeleton of lower jaw +relationship: RO:0000052 UBERON:0003278 ! inheres in skeleton of lower jaw [Term] id: OBA:0003506 @@ -132051,7 +231402,7 @@ synonym: "amount of trunk or cervical vertebra" EXACT [AUTO:patterns/patterns/en is_a: OBA:0002371 ! vertebra amount is_a: OBA:1000660 ! trunk or cervical vertebra quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004451 ! trunk or cervical vertebra +intersection_of: RO:0000052 UBERON:0004451 ! inheres in trunk or cervical vertebra [Term] id: OBA:0003507 @@ -132061,7 +231412,7 @@ synonym: "size of epithelium of esophagus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000468 ! esophageal epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001976 ! epithelium of esophagus +intersection_of: RO:0000052 UBERON:0001976 ! inheres in epithelium of esophagus [Term] id: OBA:0003508 @@ -132070,8 +231421,8 @@ def: "The morphology of a stomach non-glandular epithelium." [AUTO:patterns/patt synonym: "morphology of stomach non-glandular epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000471 ! stomach epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010040 ! stomach non-glandular epithelium -relationship: inheres_in UBERON:0010040 ! stomach non-glandular epithelium +intersection_of: RO:0000052 UBERON:0010040 ! inheres in stomach non-glandular epithelium +relationship: RO:0000052 UBERON:0010040 ! inheres in stomach non-glandular epithelium [Term] id: OBA:0003509 @@ -132080,8 +231431,8 @@ def: "The onset quality of a digestive tract development." [AUTO:patterns/patter synonym: "onset quality of digestive tract development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0048565 ! digestive tract development -relationship: inheres_in GO:0048565 ! digestive tract development +intersection_of: RO:0000052 GO:0048565 ! inheres in digestive tract development +relationship: RO:0000052 GO:0048565 ! inheres in digestive tract development [Term] id: OBA:0003510 @@ -132090,8 +231441,8 @@ def: "The morphology of a pulmonary trunk." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pulmonary trunk" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002333 ! pulmonary trunk -relationship: inheres_in UBERON:0002333 ! pulmonary trunk +intersection_of: RO:0000052 UBERON:0002333 ! inheres in pulmonary trunk +relationship: RO:0000052 UBERON:0002333 ! inheres in pulmonary trunk [Term] id: OBA:0003511 @@ -132101,8 +231452,8 @@ synonym: "amount of nephron tubule" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001231 ! nephron tubule -relationship: inheres_in UBERON:0001231 ! nephron tubule +intersection_of: RO:0000052 UBERON:0001231 ! inheres in nephron tubule +relationship: RO:0000052 UBERON:0001231 ! inheres in nephron tubule [Term] id: OBA:0003512 @@ -132112,7 +231463,7 @@ synonym: "size of inner medulla of kidney" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005407 ! inner medulla of kidney morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001294 ! inner medulla of kidney +intersection_of: RO:0000052 UBERON:0001294 ! inheres in inner medulla of kidney [Term] id: OBA:0003513 @@ -132122,7 +231473,7 @@ synonym: "onset quality of kidney development" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0000527 ! kidney development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001822 ! kidney development +intersection_of: RO:0000052 GO:0001822 ! inheres in kidney development [Term] id: OBA:0003514 @@ -132133,7 +231484,7 @@ is_a: OBA:0003741 ! viscus spatial pattern is_a: OBA:0004777 ! right lung morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002167 ! right lung +intersection_of: RO:0000052 UBERON:0002167 ! inheres in right lung [Term] id: OBA:0003515 @@ -132143,7 +231494,7 @@ synonym: "structure of kidney blood vessel" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003463 ! blood vessel structure is_a: OBA:VT0000530 ! kidney blood vessel morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003517 ! kidney blood vessel +intersection_of: RO:0000052 UBERON:0003517 ! inheres in kidney blood vessel [Term] id: OBA:0003516 @@ -132153,8 +231504,8 @@ synonym: "size of ureter luminal urothelium" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011947 ! ureter luminal urothelium -relationship: inheres_in UBERON:0011947 ! ureter luminal urothelium +intersection_of: RO:0000052 UBERON:0011947 ! inheres in ureter luminal urothelium +relationship: RO:0000052 UBERON:0011947 ! inheres in ureter luminal urothelium [Term] id: OBA:0003517 @@ -132164,7 +231515,7 @@ synonym: "size of urinary bladder urothelium" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000541 ! urinary bladder transitional epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004645 ! urinary bladder urothelium +intersection_of: RO:0000052 UBERON:0004645 ! inheres in urinary bladder urothelium [Term] id: OBA:0003518 @@ -132174,8 +231525,8 @@ synonym: "morphology of carpal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001435 ! carpal bone -relationship: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone +relationship: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0003519 @@ -132185,7 +231536,7 @@ synonym: "displaced of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000577 ! digit quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:0003520 @@ -132195,8 +231546,8 @@ synonym: "degree of pigmentation of epidermis of metapodial pad" EXACT [AUTO:pat is_a: OBA:1000109 ! anatomical pigmentation is_a: OBA:VT0001216 ! epidermis morphology trait intersection_of: PATO:0002247 ! degree of pigmentation -intersection_of: inheres_in UBERON:0015484 ! epidermis of metapodial pad -relationship: inheres_in UBERON:0015484 ! epidermis of metapodial pad +intersection_of: RO:0000052 UBERON:0015484 ! inheres in epidermis of metapodial pad +relationship: RO:0000052 UBERON:0015484 ! inheres in epidermis of metapodial pad [Term] id: OBA:0003521 @@ -132206,7 +231557,7 @@ synonym: "shape of post-anal tail" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003693 ! post-anal tail morphology is_a: OBA:VT0003051 ! tail shape trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0003522 @@ -132216,7 +231567,7 @@ synonym: "size of post-anal tail" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003693 ! post-anal tail morphology is_a: OBA:VT0003456 ! tail size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0003523 @@ -132226,7 +231577,7 @@ synonym: "length of post-anal tail" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003522 ! post-anal tail size is_a: OBA:VT0002758 ! tail length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0003524 @@ -132236,7 +231587,7 @@ synonym: "onset quality of liver development" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0000596 ! liver development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001889 ! liver development +intersection_of: RO:0000052 GO:0001889 ! inheres in liver development [Term] id: OBA:0003525 @@ -132246,7 +231597,7 @@ synonym: "size of liver perisinusoidal space" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0004555 ! liver perisinusoidal space morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006729 ! liver perisinusoidal space +intersection_of: RO:0000052 UBERON:0006729 ! inheres in liver perisinusoidal space [Term] id: OBA:0003526 @@ -132256,7 +231607,7 @@ synonym: "color saturation of liver" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000635 ! liver quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:0003527 @@ -132266,8 +231617,8 @@ synonym: "amount of hepatocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000182 ! hepatocyte -relationship: inheres_in CL:0000182 ! hepatocyte +intersection_of: RO:0000052 CL:0000182 ! inheres in hepatocyte +relationship: RO:0000052 CL:0000182 ! inheres in hepatocyte [Term] id: OBA:0003528 @@ -132277,7 +231628,7 @@ synonym: "organization quality of hepatocyte" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0000607 ! hepatocyte morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in CL:0000182 ! hepatocyte +intersection_of: RO:0000052 CL:0000182 ! inheres in hepatocyte [Term] id: OBA:0003529 @@ -132287,7 +231638,7 @@ synonym: "size of saliva-secreting gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000613 ! salivary gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001044 ! saliva-secreting gland +intersection_of: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland [Term] id: OBA:0003530 @@ -132296,8 +231647,8 @@ def: "The size of a salivary gland epithelium." [AUTO:patterns/patterns/entity_a synonym: "size of salivary gland epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004809 ! salivary gland epithelium -relationship: inheres_in UBERON:0004809 ! salivary gland epithelium +intersection_of: RO:0000052 UBERON:0004809 ! inheres in salivary gland epithelium +relationship: RO:0000052 UBERON:0004809 ! inheres in salivary gland epithelium [Term] id: OBA:0003531 @@ -132307,7 +231658,7 @@ synonym: "size of duct of salivary gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000172 ! tube size is_a: OBA:VT0000620 ! salivary duct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001837 ! duct of salivary gland +intersection_of: RO:0000052 UBERON:0001837 ! inheres in duct of salivary gland [Term] id: OBA:0003532 @@ -132317,7 +231668,7 @@ synonym: "rate of saliva secretion" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0000623 ! salivation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0046541 ! saliva secretion +intersection_of: RO:0000052 GO:0046541 ! inheres in saliva secretion [Term] id: OBA:0003533 @@ -132327,7 +231678,7 @@ synonym: "size of cortical cell of adrenal gland" EXACT [AUTO:patterns/patterns/ is_a: OBA:0000055 ! cell size is_a: OBA:VT0000646 ! adrenocortical cell morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0002097 ! cortical cell of adrenal gland +intersection_of: RO:0000052 CL:0002097 ! inheres in cortical cell of adrenal gland [Term] id: OBA:0003534 @@ -132337,7 +231688,7 @@ synonym: "size of prostate gland dorsolateral lobe" EXACT [AUTO:patterns/pattern is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004709 ! prostate gland dorsolateral lobe morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008808 ! prostate gland dorsolateral lobe +intersection_of: RO:0000052 UBERON:0008808 ! inheres in prostate gland dorsolateral lobe [Term] id: OBA:0003535 @@ -132347,7 +231698,7 @@ synonym: "size of hemopoietic organ" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003737 ! hemopoietic organ morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004177 ! hemopoietic organ +intersection_of: RO:0000052 UBERON:0004177 ! inheres in hemopoietic organ [Term] id: OBA:0003536 @@ -132356,8 +231707,8 @@ def: "The size of a lymphoid tissue." [AUTO:patterns/patterns/entity_attribute] synonym: "size of lymphoid tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001744 ! lymphoid tissue -relationship: inheres_in UBERON:0001744 ! lymphoid tissue +intersection_of: RO:0000052 UBERON:0001744 ! inheres in lymphoid tissue +relationship: RO:0000052 UBERON:0001744 ! inheres in lymphoid tissue [Term] id: OBA:0003537 @@ -132367,8 +231718,8 @@ synonym: "morphology of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003737 ! hemopoietic organ morphology is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:0003538 @@ -132378,8 +231729,8 @@ synonym: "amount of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000029 ! lymph node -relationship: inheres_in UBERON:0000029 ! lymph node +intersection_of: RO:0000052 UBERON:0000029 ! inheres in lymph node +relationship: RO:0000052 UBERON:0000029 ! inheres in lymph node [Term] id: OBA:0003539 @@ -132390,8 +231741,8 @@ is_a: OBA:0003737 ! hemopoietic organ morphology is_a: OBA:0005864 ! endocrine gland morphology is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002370 ! thymus -relationship: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus +relationship: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:0003540 @@ -132401,7 +231752,7 @@ synonym: "size of cortex of thymus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002371 ! thymus cortex morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002123 ! cortex of thymus +intersection_of: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus [Term] id: OBA:0003541 @@ -132410,8 +231761,8 @@ def: "The amount of a thymocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000893 ! thymocyte -relationship: inheres_in CL:0000893 ! thymocyte +intersection_of: RO:0000052 CL:0000893 ! inheres in thymocyte +relationship: RO:0000052 CL:0000893 ! inheres in thymocyte [Term] id: OBA:0003542 @@ -132420,8 +231771,8 @@ def: "The amount of a skeletal muscle satellite cell." [AUTO:patterns/patterns/e synonym: "amount of skeletal muscle satellite cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004713 ! cell of skeletal muscle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000594 ! skeletal muscle satellite cell -relationship: inheres_in CL:0000594 ! skeletal muscle satellite cell +intersection_of: RO:0000052 CL:0000594 ! inheres in skeletal muscle satellite cell +relationship: RO:0000052 CL:0000594 ! inheres in skeletal muscle satellite cell [Term] id: OBA:0003543 @@ -132430,8 +231781,8 @@ def: "The onset quality of a muscle organ development." [AUTO:patterns/patterns/ synonym: "onset quality of muscle organ development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007517 ! muscle organ development -relationship: inheres_in GO:0007517 ! muscle organ development +intersection_of: RO:0000052 GO:0007517 ! inheres in muscle organ development +relationship: RO:0000052 GO:0007517 ! inheres in muscle organ development [Term] id: OBA:0003544 @@ -132441,8 +231792,8 @@ synonym: "rate of muscle contraction" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006936 ! muscle contraction -relationship: inheres_in GO:0006936 ! muscle contraction +intersection_of: RO:0000052 GO:0006936 ! inheres in muscle contraction +relationship: RO:0000052 GO:0006936 ! inheres in muscle contraction [Term] id: OBA:0003545 @@ -132451,8 +231802,8 @@ def: "The rate of a smooth muscle contraction." [AUTO:patterns/patterns/entity_a synonym: "rate of smooth muscle contraction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003544 ! muscle contraction rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006939 ! smooth muscle contraction -relationship: inheres_in GO:0006939 ! smooth muscle contraction +intersection_of: RO:0000052 GO:0006939 ! inheres in smooth muscle contraction +relationship: RO:0000052 GO:0006939 ! inheres in smooth muscle contraction [Term] id: OBA:0003546 @@ -132462,7 +231813,7 @@ synonym: "degeneration of muscle organ" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003692 ! muscle organ morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0003547 @@ -132472,7 +231823,7 @@ synonym: "movement behavioral quality of organism subdivision" EXACT [AUTO:patte is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0002076 ! movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0000475 ! organism subdivision +intersection_of: RO:0000052 UBERON:0000475 ! inheres in organism subdivision [Term] id: OBA:0003548 @@ -132482,8 +231833,8 @@ synonym: "amount of tongue squamous epithelium" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006919 ! tongue squamous epithelium -relationship: inheres_in UBERON:0006919 ! tongue squamous epithelium +intersection_of: RO:0000052 UBERON:0006919 ! inheres in tongue squamous epithelium +relationship: RO:0000052 UBERON:0006919 ! inheres in tongue squamous epithelium [Term] id: OBA:0003549 @@ -132493,7 +231844,7 @@ synonym: "size of forebrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000783 ! forebrain morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001890 ! forebrain +intersection_of: RO:0000052 UBERON:0001890 ! inheres in forebrain [Term] id: OBA:0003550 @@ -132503,7 +231854,7 @@ synonym: "stratification of cerebral cortex" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000788 ! cerebral cortex morphology trait is_a: PATO:0002067 ! stratification intersection_of: PATO:0002067 ! stratification -intersection_of: inheres_in UBERON:0000956 ! cerebral cortex +intersection_of: RO:0000052 UBERON:0000956 ! inheres in cerebral cortex [Term] id: OBA:0003551 @@ -132513,8 +231864,8 @@ synonym: "morphology of supplemental motor cortex" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0016636 ! supplemental motor cortex -relationship: inheres_in UBERON:0016636 ! supplemental motor cortex +intersection_of: RO:0000052 UBERON:0016636 ! inheres in supplemental motor cortex +relationship: RO:0000052 UBERON:0016636 ! inheres in supplemental motor cortex [Term] id: OBA:0003552 @@ -132524,7 +231875,7 @@ synonym: "degeneration of hippocampal neuron" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0015046 ! hippocampus neuron morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002608 ! hippocampal neuron +intersection_of: RO:0000052 CL:0002608 ! inheres in hippocampal neuron [Term] id: OBA:0003553 @@ -132534,7 +231885,7 @@ synonym: "size of choroid plexus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000820 ! choroid plexus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001886 ! choroid plexus +intersection_of: RO:0000052 UBERON:0001886 ! inheres in choroid plexus [Term] id: OBA:0003554 @@ -132544,7 +231895,7 @@ synonym: "size of diencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000830 ! diencephalon morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001894 ! diencephalon +intersection_of: RO:0000052 UBERON:0001894 ! inheres in diencephalon [Term] id: OBA:0003555 @@ -132554,7 +231905,7 @@ synonym: "size of hypothalamus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000837 ! hypothalamus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001898 ! hypothalamus +intersection_of: RO:0000052 UBERON:0001898 ! inheres in hypothalamus [Term] id: OBA:0003556 @@ -132564,8 +231915,8 @@ synonym: "deviation (from_normal) of pontine flexure" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0005820 ! pontine flexure -relationship: inheres_in UBERON:0005820 ! pontine flexure +intersection_of: RO:0000052 UBERON:0005820 ! inheres in pontine flexure +relationship: RO:0000052 UBERON:0005820 ! inheres in pontine flexure [Term] id: OBA:0003557 @@ -132575,7 +231926,7 @@ synonym: "organization quality of barrel cortex" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0003989 ! barrel cortex morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0010415 ! barrel cortex +intersection_of: RO:0000052 UBERON:0010415 ! inheres in barrel cortex [Term] id: OBA:0003558 @@ -132585,7 +231936,7 @@ synonym: "size of cerebellum external granule cell layer" EXACT [AUTO:patterns/p is_a: OBA:0004187 ! granular layer of cerebellar cortex size is_a: OBA:VT0000872 ! external granule cell layer morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008829 ! cerebellum external granule cell layer +intersection_of: RO:0000052 UBERON:0008829 ! inheres in cerebellum external granule cell layer [Term] id: OBA:0003559 @@ -132595,7 +231946,7 @@ synonym: "degeneration of Purkinje cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0000877 ! Purkinje cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000121 ! Purkinje cell +intersection_of: RO:0000052 CL:0000121 ! inheres in Purkinje cell [Term] id: OBA:0003560 @@ -132604,8 +231955,8 @@ def: "The amount of a Purkinje cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of Purkinje cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000121 ! Purkinje cell -relationship: inheres_in CL:0000121 ! Purkinje cell +intersection_of: RO:0000052 CL:0000121 ! inheres in Purkinje cell +relationship: RO:0000052 CL:0000121 ! inheres in Purkinje cell [Term] id: OBA:0003561 @@ -132615,7 +231966,7 @@ synonym: "structure of Purkinje cell layer of cerebellar cortex" EXACT [AUTO:pat is_a: OBA:VT0000875 ! cerebellar Purkinje cell layer morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002979 ! Purkinje cell layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002979 ! inheres in Purkinje cell layer of cerebellar cortex [Term] id: OBA:0003562 @@ -132624,8 +231975,8 @@ def: "The displaced of a Purkinje cell." [AUTO:patterns/patterns/entity_attribut synonym: "displaced of Purkinje cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005527 ! neuron displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000121 ! Purkinje cell -relationship: inheres_in CL:0000121 ! Purkinje cell +intersection_of: RO:0000052 CL:0000121 ! inheres in Purkinje cell +relationship: RO:0000052 CL:0000121 ! inheres in Purkinje cell [Term] id: OBA:0003563 @@ -132635,7 +231986,7 @@ synonym: "structure of granular layer of cerebellar cortex" EXACT [AUTO:patterns is_a: OBA:VT0000886 ! cerebellar granule layer morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002956 ! granular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002956 ! inheres in granular layer of cerebellar cortex [Term] id: OBA:0003564 @@ -132645,7 +231996,7 @@ synonym: "size of molecular layer of cerebellar cortex" EXACT [AUTO:patterns/pat is_a: OBA:VT0000889 ! cerebellar molecular layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002974 ! molecular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002974 ! inheres in molecular layer of cerebellar cortex [Term] id: OBA:0003565 @@ -132655,7 +232006,7 @@ synonym: "size of midbrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000897 ! midbrain morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001891 ! midbrain +intersection_of: RO:0000052 UBERON:0001891 ! inheres in midbrain [Term] id: OBA:0003566 @@ -132665,8 +232016,8 @@ synonym: "morphology of facial nucleus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000127 ! facial nucleus -relationship: inheres_in UBERON:0000127 ! facial nucleus +intersection_of: RO:0000052 UBERON:0000127 ! inheres in facial nucleus +relationship: RO:0000052 UBERON:0000127 ! inheres in facial nucleus [Term] id: OBA:0003567 @@ -132676,7 +232027,7 @@ synonym: "size of facial nucleus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003566 ! facial nucleus morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000127 ! facial nucleus +intersection_of: RO:0000052 UBERON:0000127 ! inheres in facial nucleus [Term] id: OBA:0003568 @@ -132686,7 +232037,7 @@ synonym: "closure of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010612 ! cranium morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:0003569 @@ -132696,8 +232047,8 @@ synonym: "amount of roof plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003054 ! roof plate -relationship: inheres_in UBERON:0003054 ! roof plate +intersection_of: RO:0000052 UBERON:0003054 ! inheres in roof plate +relationship: RO:0000052 UBERON:0003054 ! inheres in roof plate [Term] id: OBA:0003570 @@ -132707,8 +232058,8 @@ synonym: "amount of floor plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003079 ! floor plate -relationship: inheres_in UBERON:0003079 ! floor plate +intersection_of: RO:0000052 UBERON:0003079 ! inheres in floor plate +relationship: RO:0000052 UBERON:0003079 ! inheres in floor plate [Term] id: OBA:0003571 @@ -132718,7 +232069,7 @@ synonym: "closure of anterior neuropore" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005694 ! anterior neuropore morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0005070 ! anterior neuropore +intersection_of: RO:0000052 UBERON:0005070 ! inheres in anterior neuropore [Term] id: OBA:0003572 @@ -132728,7 +232079,7 @@ synonym: "occurrence of neural tube closure" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000602 ! neural tube closure quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0001843 ! neural tube closure +intersection_of: RO:0000052 GO:0001843 ! inheres in neural tube closure [Term] id: OBA:0003573 @@ -132738,7 +232089,7 @@ synonym: "shape of neural tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001054 ! neural tube morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001049 ! neural tube +intersection_of: RO:0000052 UBERON:0001049 ! inheres in neural tube [Term] id: OBA:0003574 @@ -132748,8 +232099,8 @@ synonym: "amount of notochord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002328 ! notochord -relationship: inheres_in UBERON:0002328 ! notochord +intersection_of: RO:0000052 UBERON:0002328 ! inheres in notochord +relationship: RO:0000052 UBERON:0002328 ! inheres in notochord [Term] id: OBA:0003575 @@ -132759,7 +232110,7 @@ synonym: "degeneration of peripheral nervous system" EXACT [AUTO:patterns/patter is_a: OBA:1000226 ! peripheral nervous system quality is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000010 ! peripheral nervous system +intersection_of: RO:0000052 UBERON:0000010 ! inheres in peripheral nervous system [Term] id: OBA:0003576 @@ -132769,7 +232120,7 @@ synonym: "organization quality of dorsal root ganglion" EXACT [AUTO:patterns/pat is_a: OBA:VT0000961 ! dorsal root ganglion morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0000044 ! dorsal root ganglion +intersection_of: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion [Term] id: OBA:0003577 @@ -132778,8 +232129,8 @@ def: "The amount of a sensory neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of sensory neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000101 ! sensory neuron -relationship: inheres_in CL:0000101 ! sensory neuron +intersection_of: RO:0000052 CL:0000101 ! inheres in sensory neuron +relationship: RO:0000052 CL:0000101 ! inheres in sensory neuron [Term] id: OBA:0003578 @@ -132788,8 +232139,8 @@ def: "The morphology of a polymodal nocireceptor." [AUTO:patterns/patterns/entit synonym: "morphology of polymodal nocireceptor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000969 ! nociceptor morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000567 ! polymodal nocireceptor -relationship: inheres_in CL:0000567 ! polymodal nocireceptor +intersection_of: RO:0000052 CL:0000567 ! inheres in polymodal nocireceptor +relationship: RO:0000052 CL:0000567 ! inheres in polymodal nocireceptor [Term] id: OBA:0003579 @@ -132798,8 +232149,8 @@ def: "The morphology of a thermoreceptor cell." [AUTO:patterns/patterns/entity_a synonym: "morphology of thermoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000205 ! thermoreceptor cell -relationship: inheres_in CL:0000205 ! thermoreceptor cell +intersection_of: RO:0000052 CL:0000205 ! inheres in thermoreceptor cell +relationship: RO:0000052 CL:0000205 ! inheres in thermoreceptor cell [Term] id: OBA:0003580 @@ -132808,8 +232159,8 @@ def: "The morphology of a cutaneous/subcutaneous mechanoreceptor cell." [AUTO:pa synonym: "morphology of cutaneous/subcutaneous mechanoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell -relationship: inheres_in CL:0002487 ! cutaneous/subcutaneous mechanoreceptor cell +intersection_of: RO:0000052 CL:0002487 ! inheres in cutaneous/subcutaneous mechanoreceptor cell +relationship: RO:0000052 CL:0002487 ! inheres in cutaneous/subcutaneous mechanoreceptor cell [Term] id: OBA:0003581 @@ -132818,8 +232169,8 @@ def: "The morphology of a hair-tylotrich neuron." [AUTO:patterns/patterns/entity synonym: "morphology of hair-tylotrich neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003580 ! cutaneous/subcutaneous mechanoreceptor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001436 ! hair-tylotrich neuron -relationship: inheres_in CL:1001436 ! hair-tylotrich neuron +intersection_of: RO:0000052 CL:1001436 ! inheres in hair-tylotrich neuron +relationship: RO:0000052 CL:1001436 ! inheres in hair-tylotrich neuron [Term] id: OBA:0003582 @@ -132828,8 +232179,8 @@ def: "The morphology of a hair-down neuron." [AUTO:patterns/patterns/entity_attr synonym: "morphology of hair-down neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003580 ! cutaneous/subcutaneous mechanoreceptor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001437 ! hair-down neuron -relationship: inheres_in CL:1001437 ! hair-down neuron +intersection_of: RO:0000052 CL:1001437 ! inheres in hair-down neuron +relationship: RO:0000052 CL:1001437 ! inheres in hair-down neuron [Term] id: OBA:0003583 @@ -132838,8 +232189,8 @@ def: "The amount of a hair-down neuron." [AUTO:patterns/patterns/entity_attribut synonym: "amount of hair-down neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003577 ! sensory neuron amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1001437 ! hair-down neuron -relationship: inheres_in CL:1001437 ! hair-down neuron +intersection_of: RO:0000052 CL:1001437 ! inheres in hair-down neuron +relationship: RO:0000052 CL:1001437 ! inheres in hair-down neuron [Term] id: OBA:0003584 @@ -132848,8 +232199,8 @@ def: "The morphology of a Merkel cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of Merkel cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002655 ! keratinocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000242 ! Merkel cell -relationship: inheres_in CL:0000242 ! Merkel cell +intersection_of: RO:0000052 CL:0000242 ! inheres in Merkel cell +relationship: RO:0000052 CL:0000242 ! inheres in Merkel cell [Term] id: OBA:0003585 @@ -132859,8 +232210,8 @@ synonym: "amount of Merkel cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000242 ! Merkel cell -relationship: inheres_in CL:0000242 ! Merkel cell +intersection_of: RO:0000052 CL:0000242 ! inheres in Merkel cell +relationship: RO:0000052 CL:0000242 ! inheres in Merkel cell [Term] id: OBA:0003586 @@ -132869,8 +232220,8 @@ def: "The amount of a primary muscle spindle." [AUTO:patterns/patterns/entity_at synonym: "amount of primary muscle spindle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004430 ! muscle spindle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004010 ! primary muscle spindle -relationship: inheres_in UBERON:0004010 ! primary muscle spindle +intersection_of: RO:0000052 UBERON:0004010 ! inheres in primary muscle spindle +relationship: RO:0000052 UBERON:0004010 ! inheres in primary muscle spindle [Term] id: OBA:0003587 @@ -132879,8 +232230,8 @@ def: "The amount of a secondary muscle spindle." [AUTO:patterns/patterns/entity_ synonym: "amount of secondary muscle spindle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004430 ! muscle spindle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004011 ! secondary muscle spindle -relationship: inheres_in UBERON:0004011 ! secondary muscle spindle +intersection_of: RO:0000052 UBERON:0004011 ! inheres in secondary muscle spindle +relationship: RO:0000052 UBERON:0004011 ! inheres in secondary muscle spindle [Term] id: OBA:0003588 @@ -132890,8 +232241,8 @@ synonym: "amount of golgi tendon organ" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004012 ! golgi tendon organ -relationship: inheres_in UBERON:0004012 ! golgi tendon organ +intersection_of: RO:0000052 UBERON:0004012 ! inheres in golgi tendon organ +relationship: RO:0000052 UBERON:0004012 ! inheres in golgi tendon organ [Term] id: OBA:0003589 @@ -132900,8 +232251,8 @@ def: "The morphology of a chemoreceptor cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of chemoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000206 ! chemoreceptor cell -relationship: inheres_in CL:0000206 ! chemoreceptor cell +intersection_of: RO:0000052 CL:0000206 ! inheres in chemoreceptor cell +relationship: RO:0000052 CL:0000206 ! inheres in chemoreceptor cell [Term] id: OBA:0003590 @@ -132910,8 +232261,8 @@ def: "The morphology of a eye photoreceptor cell." [AUTO:patterns/patterns/entit synonym: "morphology of eye photoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000287 ! eye photoreceptor cell -relationship: inheres_in CL:0000287 ! eye photoreceptor cell +intersection_of: RO:0000052 CL:0000287 ! inheres in eye photoreceptor cell +relationship: RO:0000052 CL:0000287 ! inheres in eye photoreceptor cell [Term] id: OBA:0003591 @@ -132921,7 +232272,7 @@ synonym: "size of prevertebral ganglion" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015051 ! prevertebral ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003964 ! prevertebral ganglion +intersection_of: RO:0000052 UBERON:0003964 ! inheres in prevertebral ganglion [Term] id: OBA:0003592 @@ -132930,8 +232281,8 @@ def: "The morphology of a autonomic neuron." [AUTO:patterns/patterns/entity_attr synonym: "morphology of autonomic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000107 ! autonomic neuron -relationship: inheres_in CL:0000107 ! autonomic neuron +intersection_of: RO:0000052 CL:0000107 ! inheres in autonomic neuron +relationship: RO:0000052 CL:0000107 ! inheres in autonomic neuron [Term] id: OBA:0003593 @@ -132941,8 +232292,8 @@ synonym: "morphology of enteric nerve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010380 ! enteric nerve -relationship: inheres_in UBERON:0010380 ! enteric nerve +intersection_of: RO:0000052 UBERON:0010380 ! inheres in enteric nerve +relationship: RO:0000052 UBERON:0010380 ! inheres in enteric nerve [Term] id: OBA:0003594 @@ -132951,8 +232302,8 @@ def: "The morphology of a cholinergic enteric nerve." [AUTO:patterns/patterns/en synonym: "morphology of cholinergic enteric nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003593 ! enteric nerve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010406 ! cholinergic enteric nerve -relationship: inheres_in UBERON:0010406 ! cholinergic enteric nerve +intersection_of: RO:0000052 UBERON:0010406 ! inheres in cholinergic enteric nerve +relationship: RO:0000052 UBERON:0010406 ! inheres in cholinergic enteric nerve [Term] id: OBA:0003595 @@ -132962,7 +232313,7 @@ synonym: "branchiness of mandibular nerve" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0001067 ! mandibular nerve morphology trait is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0000375 ! mandibular nerve +intersection_of: RO:0000052 UBERON:0000375 ! inheres in mandibular nerve [Term] id: OBA:0003596 @@ -132972,8 +232323,8 @@ synonym: "amount of phrenic nerve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000471 ! nerve quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001884 ! phrenic nerve -relationship: inheres_in UBERON:0001884 ! phrenic nerve +intersection_of: RO:0000052 UBERON:0001884 ! inheres in phrenic nerve +relationship: RO:0000052 UBERON:0001884 ! inheres in phrenic nerve [Term] id: OBA:0003597 @@ -132983,7 +232334,7 @@ synonym: "size of inferior glossopharyngeal IX ganglion" EXACT [AUTO:patterns/pa is_a: OBA:VT0001084 ! petrosal ganglion morphology trait is_a: OBA:VT0001085 ! petrosal ganglion size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005360 ! inferior glossopharyngeal IX ganglion +intersection_of: RO:0000052 UBERON:0005360 ! inheres in inferior glossopharyngeal IX ganglion [Term] id: OBA:0003598 @@ -132993,7 +232344,7 @@ synonym: "amount of myelinating Schwann cell" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0005180 ! Schwann cell amount is_a: OBA:1000482 ! myelinating Schwann cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000218 ! myelinating Schwann cell +intersection_of: RO:0000052 CL:0000218 ! inheres in myelinating Schwann cell [Term] id: OBA:0003599 @@ -133003,8 +232354,8 @@ synonym: "rate of ovarian follicle development" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001541 ! ovarian follicle development -relationship: inheres_in GO:0001541 ! ovarian follicle development +intersection_of: RO:0000052 GO:0001541 ! inheres in ovarian follicle development +relationship: RO:0000052 GO:0001541 ! inheres in ovarian follicle development [Term] id: OBA:0003600 @@ -133014,8 +232365,8 @@ synonym: "rate of artery development" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000122 ! blood vessel development trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060840 ! artery development -relationship: inheres_in GO:0060840 ! artery development +intersection_of: RO:0000052 GO:0060840 ! inheres in artery development +relationship: RO:0000052 GO:0060840 ! inheres in artery development [Term] id: OBA:0003601 @@ -133025,7 +232376,7 @@ synonym: "size of uterine cervix" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001135 ! cervix morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000002 ! uterine cervix +intersection_of: RO:0000052 UBERON:0000002 ! inheres in uterine cervix [Term] id: OBA:0003602 @@ -133035,7 +232386,7 @@ synonym: "size of epithelium of vagina" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001140 ! vaginal epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001344 ! epithelium of vagina +intersection_of: RO:0000052 UBERON:0001344 ! inheres in epithelium of vagina [Term] id: OBA:0003603 @@ -133045,7 +232396,7 @@ synonym: "structure of vagina orifice" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0001142 ! vaginal opening morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0012317 ! vagina orifice +intersection_of: RO:0000052 UBERON:0012317 ! inheres in vagina orifice [Term] id: OBA:0003604 @@ -133055,7 +232406,7 @@ synonym: "size of skin of prepuce of penis" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003618 ! zone of skin size is_a: OBA:0003836 ! skin of prepuce of penis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001471 ! skin of prepuce of penis +intersection_of: RO:0000052 UBERON:0001471 ! inheres in skin of prepuce of penis [Term] id: OBA:0003605 @@ -133065,7 +232416,7 @@ synonym: "size of Leydig cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0002786 ! Leydig cell morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000178 ! Leydig cell +intersection_of: RO:0000052 CL:0000178 ! inheres in Leydig cell [Term] id: OBA:0003606 @@ -133075,7 +232426,7 @@ synonym: "degeneration of seminiferous tubule of testis" EXACT [AUTO:patterns/pa is_a: OBA:VT0002216 ! seminiferous tubule morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001343 ! seminiferous tubule of testis +intersection_of: RO:0000052 UBERON:0001343 ! inheres in seminiferous tubule of testis [Term] id: OBA:0003607 @@ -133085,7 +232436,7 @@ synonym: "occurrence of spermatogenesis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0001156 ! spermatogenesis trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0007283 ! spermatogenesis +intersection_of: RO:0000052 GO:0007283 ! inheres in spermatogenesis [Term] id: OBA:0003608 @@ -133095,7 +232446,7 @@ synonym: "size of prostate epithelium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001168 ! prostate epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000428 ! prostate epithelium +intersection_of: RO:0000052 UBERON:0000428 ! inheres in prostate epithelium [Term] id: OBA:0003609 @@ -133105,7 +232456,7 @@ synonym: "structure of prostate epithelium" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0001168 ! prostate epithelium morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000428 ! prostate epithelium +intersection_of: RO:0000052 UBERON:0000428 ! inheres in prostate epithelium [Term] id: OBA:0003610 @@ -133115,7 +232466,7 @@ synonym: "size of interalveolar septum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005257 ! interalveolar septum morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004893 ! interalveolar septum +intersection_of: RO:0000052 UBERON:0004893 ! inheres in interalveolar septum [Term] id: OBA:0003611 @@ -133125,7 +232476,7 @@ synonym: "size of alveolar system" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005256 ! alveolar system morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006524 ! alveolar system +intersection_of: RO:0000052 UBERON:0006524 ! inheres in alveolar system [Term] id: OBA:0003612 @@ -133135,8 +232486,8 @@ synonym: "amount of alveolar system" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006524 ! alveolar system -relationship: inheres_in UBERON:0006524 ! alveolar system +intersection_of: RO:0000052 UBERON:0006524 ! inheres in alveolar system +relationship: RO:0000052 UBERON:0006524 ! inheres in alveolar system [Term] id: OBA:0003613 @@ -133146,8 +232497,8 @@ synonym: "rate of pigmentation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0043473 ! pigmentation -relationship: inheres_in GO:0043473 ! pigmentation +intersection_of: RO:0000052 GO:0043473 ! inheres in pigmentation +relationship: RO:0000052 GO:0043473 ! inheres in pigmentation [Term] id: OBA:0003614 @@ -133157,7 +232508,7 @@ synonym: "color of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002096 ! skin morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003615 @@ -133167,7 +232518,7 @@ synonym: "texture of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002096 ! skin morphology trait is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003616 @@ -133177,8 +232528,8 @@ synonym: "color saturation of zone of skin" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003617 @@ -133188,7 +232539,7 @@ synonym: "spatial pattern of zone of skin" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002096 ! skin morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003618 @@ -133198,7 +232549,7 @@ synonym: "size of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003619 @@ -133208,8 +232559,8 @@ synonym: "opacity of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003620 @@ -133219,8 +232570,8 @@ synonym: "photosensitivity of zone of skin" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000927 ! photosensitivity intersection_of: PATO:0000927 ! photosensitivity -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003621 @@ -133230,8 +232581,8 @@ synonym: "sensitivity to irradiation of zone of skin" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001806 ! sensitivity to irradiation intersection_of: PATO:0001806 ! sensitivity to irradiation -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003622 @@ -133240,8 +232591,8 @@ def: "The morphology of a epidermis suprabasal layer." [AUTO:patterns/patterns/e synonym: "morphology of epidermis suprabasal layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010402 ! epidermis suprabasal layer -relationship: inheres_in UBERON:0010402 ! epidermis suprabasal layer +intersection_of: RO:0000052 UBERON:0010402 ! inheres in epidermis suprabasal layer +relationship: RO:0000052 UBERON:0010402 ! inheres in epidermis suprabasal layer [Term] id: OBA:0003623 @@ -133251,7 +232602,7 @@ synonym: "organization quality of epidermis suprabasal layer" EXACT [AUTO:patter is_a: OBA:0003622 ! epidermis suprabasal layer morphology is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0010402 ! epidermis suprabasal layer +intersection_of: RO:0000052 UBERON:0010402 ! inheres in epidermis suprabasal layer [Term] id: OBA:0003624 @@ -133261,7 +232612,7 @@ synonym: "size of stratum spinosum of epidermis" EXACT [AUTO:patterns/patterns/e is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001236 ! epidermis stratum spinosum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002026 ! stratum spinosum of epidermis +intersection_of: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis [Term] id: OBA:0003625 @@ -133271,7 +232622,7 @@ synonym: "size of dermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001243 ! dermis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002067 ! dermis +intersection_of: RO:0000052 UBERON:0002067 ! inheres in dermis [Term] id: OBA:0003626 @@ -133281,7 +232632,7 @@ synonym: "shape of vibrissa unit" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003690 ! vibrissa unit morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0003627 @@ -133291,7 +232642,7 @@ synonym: "structure of vibrissa unit" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003690 ! vibrissa unit morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0003628 @@ -133302,7 +232653,7 @@ is_a: OBA:0002777 ! pilosebaceous unit size is_a: OBA:0003690 ! vibrissa unit morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0003629 @@ -133312,7 +232663,7 @@ synonym: "spatial pattern of vibrissa unit" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003690 ! vibrissa unit morphology is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0003630 @@ -133322,8 +232673,8 @@ synonym: "amount of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0003631 @@ -133333,8 +232684,8 @@ synonym: "position of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0003632 @@ -133344,7 +232695,7 @@ synonym: "orientation of lens of camera-type eye" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0006245 ! lens orientation trait is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:0003633 @@ -133354,7 +232705,7 @@ synonym: "structure of lens fiber" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002840 ! lens fiber morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002444 ! lens fiber +intersection_of: RO:0000052 UBERON:0002444 ! inheres in lens fiber [Term] id: OBA:0003634 @@ -133364,7 +232715,7 @@ synonym: "opacity of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000536 ! cornea quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0003635 @@ -133374,7 +232725,7 @@ synonym: "opacity of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000396 ! pupil quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:0003636 @@ -133384,7 +232735,7 @@ synonym: "degeneration of retina" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001325 ! retina morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:0003637 @@ -133393,8 +232744,8 @@ def: "The amount of a eye photoreceptor cell." [AUTO:patterns/patterns/entity_at synonym: "amount of eye photoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003577 ! sensory neuron amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000287 ! eye photoreceptor cell -relationship: inheres_in CL:0000287 ! eye photoreceptor cell +intersection_of: RO:0000052 CL:0000287 ! inheres in eye photoreceptor cell +relationship: RO:0000052 CL:0000287 ! inheres in eye photoreceptor cell [Term] id: OBA:0003638 @@ -133404,8 +232755,8 @@ synonym: "morphology of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II -relationship: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II +relationship: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0003639 @@ -133415,8 +232766,8 @@ synonym: "wetness of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001822 ! wetness intersection_of: PATO:0001822 ! wetness -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0003640 @@ -133426,8 +232777,8 @@ synonym: "position of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001711 ! eyelid -relationship: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid +relationship: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:0003641 @@ -133437,8 +232788,8 @@ synonym: "rate of tear secretion" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001784 ! fluid regulation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070075 ! tear secretion -relationship: inheres_in GO:0070075 ! tear secretion +intersection_of: RO:0000052 GO:0070075 ! inheres in tear secretion +relationship: RO:0000052 GO:0070075 ! inheres in tear secretion [Term] id: OBA:0003642 @@ -133448,7 +232799,7 @@ synonym: "response to of sensory perception" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0015095 ! sensory trait is_a: PATO:0000077 ! response to intersection_of: PATO:0000077 ! response to -intersection_of: inheres_in GO:0007600 ! sensory perception +intersection_of: RO:0000052 GO:0007600 ! inheres in sensory perception [Term] id: OBA:0003643 @@ -133458,8 +232809,8 @@ synonym: "amount of long-term synaptic potentiation" EXACT [AUTO:patterns/patter is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060291 ! long-term synaptic potentiation -relationship: inheres_in GO:0060291 ! long-term synaptic potentiation +intersection_of: RO:0000052 GO:0060291 ! inheres in long-term synaptic potentiation +relationship: RO:0000052 GO:0060291 ! inheres in long-term synaptic potentiation [Term] id: OBA:0003644 @@ -133469,8 +232820,8 @@ synonym: "amount of long-term synaptic depression" EXACT [AUTO:patterns/patterns is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060292 ! long-term synaptic depression -relationship: inheres_in GO:0060292 ! long-term synaptic depression +intersection_of: RO:0000052 GO:0060292 ! inheres in long-term synaptic depression +relationship: RO:0000052 GO:0060292 ! inheres in long-term synaptic depression [Term] id: OBA:0003645 @@ -133480,8 +232831,8 @@ synonym: "morphology of coat of hair" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010166 ! coat of hair -relationship: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair +relationship: RO:0000052 UBERON:0010166 ! inheres in coat of hair [Term] id: OBA:0003646 @@ -133491,8 +232842,8 @@ synonym: "functionality of skeletal system" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001434 ! skeletal system -relationship: inheres_in UBERON:0001434 ! skeletal system +intersection_of: RO:0000052 UBERON:0001434 ! inheres in skeletal system +relationship: RO:0000052 UBERON:0001434 ! inheres in skeletal system [Term] id: OBA:0003647 @@ -133502,17 +232853,17 @@ synonym: "functionality of hematopoietic system" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000617 ! hematopoietic system quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002390 ! hematopoietic system +intersection_of: RO:0000052 UBERON:0002390 ! inheres in hematopoietic system [Term] id: OBA:0003648 name: blood volume def: "The volume of a blood." [AUTO:patterns/patterns/entity_attribute] synonym: "volume of blood" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0000036 ! body fluid levels is_a: OBA:0004999 ! blood size -is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:0003649 @@ -133522,8 +232873,8 @@ synonym: "rate of myeloid cell differentiation" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030099 ! myeloid cell differentiation -relationship: inheres_in GO:0030099 ! myeloid cell differentiation +intersection_of: RO:0000052 GO:0030099 ! inheres in myeloid cell differentiation +relationship: RO:0000052 GO:0030099 ! inheres in myeloid cell differentiation [Term] id: OBA:0003650 @@ -133533,8 +232884,8 @@ synonym: "amount of myeloid cell differentiation" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0030099 ! myeloid cell differentiation -relationship: inheres_in GO:0030099 ! myeloid cell differentiation +intersection_of: RO:0000052 GO:0030099 ! inheres in myeloid cell differentiation +relationship: RO:0000052 GO:0030099 ! inheres in myeloid cell differentiation [Term] id: OBA:0003651 @@ -133544,7 +232895,7 @@ synonym: "rate of hemopoiesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002123 ! hematopoiesis trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030097 ! hemopoiesis +intersection_of: RO:0000052 GO:0030097 ! inheres in hemopoiesis [Term] id: OBA:0003652 @@ -133554,7 +232905,7 @@ synonym: "frequency of heart contraction" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1001087 ! heart rate is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:0003653 @@ -133564,7 +232915,7 @@ synonym: "life span of multicellular organism" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000050 ! life span intersection_of: PATO:0000050 ! life span -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003654 @@ -133574,8 +232925,8 @@ synonym: "morphology of apical ectodermal ridge" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004356 ! apical ectodermal ridge -relationship: inheres_in UBERON:0004356 ! apical ectodermal ridge +intersection_of: RO:0000052 UBERON:0004356 ! inheres in apical ectodermal ridge +relationship: RO:0000052 UBERON:0004356 ! inheres in apical ectodermal ridge [Term] id: OBA:0003655 @@ -133585,7 +232936,7 @@ synonym: "size of apical ectodermal ridge" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003654 ! apical ectodermal ridge morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004356 ! apical ectodermal ridge +intersection_of: RO:0000052 UBERON:0004356 ! inheres in apical ectodermal ridge [Term] id: OBA:0003656 @@ -133595,8 +232946,8 @@ synonym: "amount of mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000926 ! mesoderm -relationship: inheres_in UBERON:0000926 ! mesoderm +intersection_of: RO:0000052 UBERON:0000926 ! inheres in mesoderm +relationship: RO:0000052 UBERON:0000926 ! inheres in mesoderm [Term] id: OBA:0003657 @@ -133606,7 +232957,7 @@ synonym: "size of endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:1001074 ! endoderm morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000925 ! endoderm +intersection_of: RO:0000052 UBERON:0000925 ! inheres in endoderm [Term] id: OBA:0003658 @@ -133616,8 +232967,8 @@ synonym: "amount of primitive streak formation" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0090009 ! primitive streak formation -relationship: inheres_in GO:0090009 ! primitive streak formation +intersection_of: RO:0000052 GO:0090009 ! inheres in primitive streak formation +relationship: RO:0000052 GO:0090009 ! inheres in primitive streak formation [Term] id: OBA:0003659 @@ -133627,7 +232978,7 @@ synonym: "amount of gastrulation" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001695 ! gastrulation trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007369 ! gastrulation +intersection_of: RO:0000052 GO:0007369 ! inheres in gastrulation [Term] id: OBA:0003660 @@ -133637,8 +232988,8 @@ synonym: "amount of amniotic fold" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005971 ! amniotic fold -relationship: inheres_in UBERON:0005971 ! amniotic fold +intersection_of: RO:0000052 UBERON:0005971 ! inheres in amniotic fold +relationship: RO:0000052 UBERON:0005971 ! inheres in amniotic fold [Term] id: OBA:0003661 @@ -133648,8 +232999,8 @@ synonym: "amount of trophoblast giant cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002488 ! trophoblast giant cell -relationship: inheres_in CL:0002488 ! trophoblast giant cell +intersection_of: RO:0000052 CL:0002488 ! inheres in trophoblast giant cell +relationship: RO:0000052 CL:0002488 ! inheres in trophoblast giant cell [Term] id: OBA:0003662 @@ -133659,7 +233010,7 @@ synonym: "size of placenta labyrinth" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001716 ! placenta labyrinth morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003946 ! placenta labyrinth +intersection_of: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth [Term] id: OBA:0003663 @@ -133669,8 +233020,8 @@ synonym: "amount of ectoplacental cone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004364 ! ectoplacental cone -relationship: inheres_in UBERON:0004364 ! ectoplacental cone +intersection_of: RO:0000052 UBERON:0004364 ! inheres in ectoplacental cone +relationship: RO:0000052 UBERON:0004364 ! inheres in ectoplacental cone [Term] id: OBA:0003664 @@ -133680,8 +233031,8 @@ synonym: "altered number of of vitelline blood vessel" EXACT [AUTO:patterns/patt is_a: OBA:VT0001614 ! blood vessel morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0004365 ! vitelline blood vessel -relationship: inheres_in UBERON:0004365 ! vitelline blood vessel +intersection_of: RO:0000052 UBERON:0004365 ! inheres in vitelline blood vessel +relationship: RO:0000052 UBERON:0004365 ! inheres in vitelline blood vessel [Term] id: OBA:0003665 @@ -133691,8 +233042,8 @@ synonym: "amount of blood island" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003061 ! blood island -relationship: inheres_in UBERON:0003061 ! blood island +intersection_of: RO:0000052 UBERON:0003061 ! inheres in blood island +relationship: RO:0000052 UBERON:0003061 ! inheres in blood island [Term] id: OBA:0003666 @@ -133702,8 +233053,8 @@ synonym: "color saturation of yolk sac" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0001040 ! yolk sac -relationship: inheres_in UBERON:0001040 ! yolk sac +intersection_of: RO:0000052 UBERON:0001040 ! inheres in yolk sac +relationship: RO:0000052 UBERON:0001040 ! inheres in yolk sac [Term] id: OBA:0003667 @@ -133713,7 +233064,7 @@ synonym: "amount of embryo implantation" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0001727 ! embryo implantation trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007566 ! embryo implantation +intersection_of: RO:0000052 GO:0007566 ! inheres in embryo implantation [Term] id: OBA:0003668 @@ -133723,7 +233074,7 @@ synonym: "rate of embryo implantation" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0001727 ! embryo implantation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007566 ! embryo implantation +intersection_of: RO:0000052 GO:0007566 ! inheres in embryo implantation [Term] id: OBA:0003669 @@ -133733,8 +233084,8 @@ synonym: "occurrence of in utero embryonic development" EXACT [AUTO:patterns/pat is_a: OBA:VT0005380 ! embryonic development trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0001701 ! in utero embryonic development -relationship: inheres_in GO:0001701 ! in utero embryonic development +intersection_of: RO:0000052 GO:0001701 ! inheres in in utero embryonic development +relationship: RO:0000052 GO:0001701 ! inheres in in utero embryonic development [Term] id: OBA:0003670 @@ -133744,7 +233095,7 @@ synonym: "rate of corticosterone secretion" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0001744 ! corticosterone secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0035934 ! corticosterone secretion +intersection_of: RO:0000052 GO:0035934 ! inheres in corticosterone secretion [Term] id: OBA:0003671 @@ -133754,8 +233105,8 @@ synonym: "rate of corticotropin-releasing hormone secretion" EXACT [AUTO:pattern is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0043396 ! corticotropin-releasing hormone secretion -relationship: inheres_in GO:0043396 ! corticotropin-releasing hormone secretion +intersection_of: RO:0000052 GO:0043396 ! inheres in corticotropin-releasing hormone secretion +relationship: RO:0000052 GO:0043396 ! inheres in corticotropin-releasing hormone secretion [Term] id: OBA:0003672 @@ -133765,7 +233116,7 @@ synonym: "frequency of micturition" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002011 ! micturition rate is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0060073 ! micturition +intersection_of: RO:0000052 GO:0060073 ! inheres in micturition [Term] id: OBA:0003673 @@ -133775,7 +233126,7 @@ synonym: "composition of zone of skin" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0002096 ! skin morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003674 @@ -133785,7 +233136,7 @@ synonym: "composition of pericardial cavity" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0005672 ! pericardial cavity morphology is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001074 ! pericardial cavity +intersection_of: RO:0000052 UBERON:0001074 ! inheres in pericardial cavity [Term] id: OBA:0003675 @@ -133795,7 +233146,7 @@ synonym: "rate of wound healing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000751 ! wound healing quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042060 ! wound healing +intersection_of: RO:0000052 GO:0042060 ! inheres in wound healing [Term] id: OBA:0003676 @@ -133805,7 +233156,7 @@ synonym: "occurrence of B cell differentiation" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0002144 ! B cell development trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0030183 ! B cell differentiation +intersection_of: RO:0000052 GO:0030183 ! inheres in B cell differentiation [Term] id: OBA:0003677 @@ -133815,7 +233166,7 @@ synonym: "occurrence of T cell differentiation" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0002145 ! T cell development trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0030217 ! T cell differentiation +intersection_of: RO:0000052 GO:0030217 ! inheres in T cell differentiation [Term] id: OBA:0003678 @@ -133824,8 +233175,8 @@ def: "The rate of a activated T cell proliferation." [AUTO:patterns/patterns/ent synonym: "rate of activated T cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004129 ! T cell proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0050798 ! activated T cell proliferation -relationship: inheres_in GO:0050798 ! activated T cell proliferation +intersection_of: RO:0000052 GO:0050798 ! inheres in activated T cell proliferation +relationship: RO:0000052 GO:0050798 ! inheres in activated T cell proliferation [Term] id: OBA:0003679 @@ -133835,8 +233186,8 @@ synonym: "rate of MHC class I protein complex assembly" EXACT [AUTO:patterns/pat is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0002397 ! MHC class I protein complex assembly -relationship: inheres_in GO:0002397 ! MHC class I protein complex assembly +intersection_of: RO:0000052 GO:0002397 ! inheres in MHC class I protein complex assembly +relationship: RO:0000052 GO:0002397 ! inheres in MHC class I protein complex assembly [Term] id: OBA:0003680 @@ -133846,8 +233197,8 @@ synonym: "rate of antigen processing and presentation of peptide antigen via MHC is_a: OBA:VT0001835 ! antigen presentation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I -relationship: inheres_in GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I +intersection_of: RO:0000052 GO:0002474 ! inheres in antigen processing and presentation of peptide antigen via MHC class I +relationship: RO:0000052 GO:0002474 ! inheres in antigen processing and presentation of peptide antigen via MHC class I [Term] id: OBA:0003681 @@ -133857,8 +233208,8 @@ synonym: "amount of MHC class I protein complex" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042612 ! MHC class I protein complex -relationship: inheres_in GO:0042612 ! MHC class I protein complex +intersection_of: RO:0000052 GO:0042612 ! inheres in MHC class I protein complex +relationship: RO:0000052 GO:0042612 ! inheres in MHC class I protein complex [Term] id: OBA:0003682 @@ -133868,7 +233219,7 @@ synonym: "size of mammary duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0001885 ! mammary duct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001765 ! mammary duct +intersection_of: RO:0000052 UBERON:0001765 ! inheres in mammary duct [Term] id: OBA:0003683 @@ -133878,7 +233229,7 @@ synonym: "onset quality of brain development" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0000913 ! brain development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007420 ! brain development +intersection_of: RO:0000052 GO:0007420 ! inheres in brain development [Term] id: OBA:0003684 @@ -133888,8 +233239,8 @@ synonym: "functionality of parietal lobe" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001872 ! parietal lobe -relationship: inheres_in UBERON:0001872 ! parietal lobe +intersection_of: RO:0000052 UBERON:0001872 ! inheres in parietal lobe +relationship: RO:0000052 UBERON:0001872 ! inheres in parietal lobe [Term] id: OBA:0003685 @@ -133899,7 +233250,7 @@ synonym: "male fertility of multicellular organism" EXACT [AUTO:patterns/pattern is_a: OBA:0002145 ! multicellular organism fertility is_a: PATO:0000279 ! male fertility intersection_of: PATO:0000279 ! male fertility -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003686 @@ -133909,7 +233260,7 @@ synonym: "female fertility of multicellular organism" EXACT [AUTO:patterns/patte is_a: OBA:0002145 ! multicellular organism fertility is_a: PATO:0000277 ! female fertility intersection_of: PATO:0000277 ! female fertility -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003687 @@ -133919,7 +233270,7 @@ synonym: "functionality of olfactory system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0005394 ! olfactory system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005725 ! olfactory system +intersection_of: RO:0000052 UBERON:0005725 ! inheres in olfactory system [Term] id: OBA:0003688 @@ -133929,7 +233280,7 @@ synonym: "structure of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001317 ! pupil morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:0003689 @@ -133939,8 +233290,8 @@ synonym: "morphology of embryonic tissue" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005291 ! embryonic tissue -relationship: inheres_in UBERON:0005291 ! embryonic tissue +intersection_of: RO:0000052 UBERON:0005291 ! inheres in embryonic tissue +relationship: RO:0000052 UBERON:0005291 ! inheres in embryonic tissue [Term] id: OBA:0003690 @@ -133950,8 +233301,8 @@ synonym: "morphology of vibrissa unit" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit -relationship: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit +relationship: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0003691 @@ -133961,8 +233312,8 @@ synonym: "functionality of muscle organ" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0003692 @@ -133972,8 +233323,8 @@ synonym: "morphology of muscle organ" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0003693 @@ -133982,8 +233333,8 @@ def: "The morphology of a post-anal tail." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of post-anal tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002111 ! tail morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007812 ! post-anal tail -relationship: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail +relationship: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0003694 @@ -133993,8 +233344,8 @@ synonym: "morphology of axial skeleton plus cranial skeleton" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005944 ! axial skeleton plus cranial skeleton -relationship: inheres_in UBERON:0005944 ! axial skeleton plus cranial skeleton +intersection_of: RO:0000052 UBERON:0005944 ! inheres in axial skeleton plus cranial skeleton +relationship: RO:0000052 UBERON:0005944 ! inheres in axial skeleton plus cranial skeleton [Term] id: OBA:0003695 @@ -134003,8 +233354,8 @@ def: "The morphology of a bone of appendage girdle complex." [AUTO:patterns/patt synonym: "morphology of bone of appendage girdle complex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010740 ! bone of appendage girdle complex -relationship: inheres_in UBERON:0010740 ! bone of appendage girdle complex +intersection_of: RO:0000052 UBERON:0010740 ! inheres in bone of appendage girdle complex +relationship: RO:0000052 UBERON:0010740 ! inheres in bone of appendage girdle complex [Term] id: OBA:0003696 @@ -134014,8 +233365,8 @@ synonym: "morphology of neural tube development" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0021915 ! neural tube development -relationship: inheres_in GO:0021915 ! neural tube development +intersection_of: RO:0000052 GO:0021915 ! inheres in neural tube development +relationship: RO:0000052 GO:0021915 ! inheres in neural tube development [Term] id: OBA:0003697 @@ -134025,7 +233376,7 @@ synonym: "fecundity of multicellular organism" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000273 ! fecundity intersection_of: PATO:0000273 ! fecundity -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003698 @@ -134035,7 +233386,7 @@ synonym: "organization quality of myocardium" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0005329 ! heart muscle morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:0003699 @@ -134045,8 +233396,8 @@ synonym: "amount of germ cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000586 ! germ cell -relationship: inheres_in CL:0000586 ! germ cell +intersection_of: RO:0000052 CL:0000586 ! inheres in germ cell +relationship: RO:0000052 CL:0000586 ! inheres in germ cell [Term] id: OBA:0003700 @@ -134056,7 +233407,7 @@ synonym: "degeneration of nervous system" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0003632 ! nervous system morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001016 ! nervous system +intersection_of: RO:0000052 UBERON:0001016 ! inheres in nervous system [Term] id: OBA:0003701 @@ -134065,8 +233416,8 @@ def: "The morphology of a larynx epithelium." [AUTO:patterns/patterns/entity_att synonym: "morphology of larynx epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004816 ! larynx epithelium -relationship: inheres_in UBERON:0004816 ! larynx epithelium +intersection_of: RO:0000052 UBERON:0004816 ! inheres in larynx epithelium +relationship: RO:0000052 UBERON:0004816 ! inheres in larynx epithelium [Term] id: OBA:0003702 @@ -134075,8 +233426,8 @@ def: "The morphology of a epithelium of trachea." [AUTO:patterns/patterns/entity synonym: "morphology of epithelium of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001901 ! epithelium of trachea -relationship: inheres_in UBERON:0001901 ! epithelium of trachea +intersection_of: RO:0000052 UBERON:0001901 ! inheres in epithelium of trachea +relationship: RO:0000052 UBERON:0001901 ! inheres in epithelium of trachea [Term] id: OBA:0003703 @@ -134085,8 +233436,8 @@ def: "The morphology of a lymph node." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000029 ! lymph node -relationship: inheres_in UBERON:0000029 ! lymph node +intersection_of: RO:0000052 UBERON:0000029 ! inheres in lymph node +relationship: RO:0000052 UBERON:0000029 ! inheres in lymph node [Term] id: OBA:0003704 @@ -134095,8 +233446,8 @@ def: "The functionality of a dendritic cell." [AUTO:patterns/patterns/entity_att synonym: "functionality of dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003714 ! professional antigen presenting cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000451 ! dendritic cell -relationship: inheres_in CL:0000451 ! dendritic cell +intersection_of: RO:0000052 CL:0000451 ! inheres in dendritic cell +relationship: RO:0000052 CL:0000451 ! inheres in dendritic cell [Term] id: OBA:0003705 @@ -134106,7 +233457,7 @@ synonym: "morphology of tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000244 ! tonsil quality is_a: OBA:VT0002378 ! gut-associated lymphoid tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002372 ! tonsil +intersection_of: RO:0000052 UBERON:0002372 ! inheres in tonsil [Term] id: OBA:0003706 @@ -134115,8 +233466,8 @@ def: "The morphology of a Peyer's patch T cell area." [AUTO:patterns/patterns/en synonym: "morphology of Peyer's patch T cell area" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010387 ! Peyer's patch T cell area -relationship: inheres_in UBERON:0010387 ! Peyer's patch T cell area +intersection_of: RO:0000052 UBERON:0010387 ! inheres in Peyer's patch T cell area +relationship: RO:0000052 UBERON:0010387 ! inheres in Peyer's patch T cell area [Term] id: OBA:0003707 @@ -134126,8 +233477,8 @@ synonym: "morphology of bone marrow" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002371 ! bone marrow -relationship: inheres_in UBERON:0002371 ! bone marrow +intersection_of: RO:0000052 UBERON:0002371 ! inheres in bone marrow +relationship: RO:0000052 UBERON:0002371 ! inheres in bone marrow [Term] id: OBA:0003708 @@ -134136,8 +233487,8 @@ def: "The morphology of a double-positive, alpha-beta thymocyte." [AUTO:patterns synonym: "morphology of double-positive, alpha-beta thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005717 ! alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000809 ! double-positive, alpha-beta thymocyte -relationship: inheres_in CL:0000809 ! double-positive, alpha-beta thymocyte +intersection_of: RO:0000052 CL:0000809 ! inheres in double-positive, alpha-beta thymocyte +relationship: RO:0000052 CL:0000809 ! inheres in double-positive, alpha-beta thymocyte [Term] id: OBA:0003709 @@ -134147,8 +233498,8 @@ synonym: "morphology of megakaryocyte progenitor cell" EXACT [AUTO:patterns/patt is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000553 ! megakaryocyte progenitor cell -relationship: inheres_in CL:0000553 ! megakaryocyte progenitor cell +intersection_of: RO:0000052 CL:0000553 ! inheres in megakaryocyte progenitor cell +relationship: RO:0000052 CL:0000553 ! inheres in megakaryocyte progenitor cell [Term] id: OBA:0003710 @@ -134157,8 +233508,8 @@ def: "The morphology of a proerythroblast." [AUTO:patterns/patterns/entity_attri synonym: "morphology of proerythroblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005897 ! erythroid lineage cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000547 ! proerythroblast -relationship: inheres_in CL:0000547 ! proerythroblast +intersection_of: RO:0000052 CL:0000547 ! inheres in proerythroblast +relationship: RO:0000052 CL:0000547 ! inheres in proerythroblast [Term] id: OBA:0003711 @@ -134168,8 +233519,8 @@ synonym: "morphology of megakaryocyte" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:0005898 ! bone marrow hematopoietic cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000556 ! megakaryocyte -relationship: inheres_in CL:0000556 ! megakaryocyte +intersection_of: RO:0000052 CL:0000556 ! inheres in megakaryocyte +relationship: RO:0000052 CL:0000556 ! inheres in megakaryocyte [Term] id: OBA:0003712 @@ -134179,8 +233530,8 @@ synonym: "morphology of osseus semicircular canal" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007833 ! osseus semicircular canal -relationship: inheres_in UBERON:0007833 ! osseus semicircular canal +intersection_of: RO:0000052 UBERON:0007833 ! inheres in osseus semicircular canal +relationship: RO:0000052 UBERON:0007833 ! inheres in osseus semicircular canal [Term] id: OBA:0003713 @@ -134189,8 +233540,8 @@ def: "The morphology of a CD4-positive, alpha-beta T cell." [AUTO:patterns/patte synonym: "morphology of CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005717 ! alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell [Term] id: OBA:0003714 @@ -134199,8 +233550,8 @@ def: "The functionality of a professional antigen presenting cell." [AUTO:patter synonym: "functionality of professional antigen presenting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002442 ! leukocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000145 ! professional antigen presenting cell -relationship: inheres_in CL:0000145 ! professional antigen presenting cell +intersection_of: RO:0000052 CL:0000145 ! inheres in professional antigen presenting cell +relationship: RO:0000052 CL:0000145 ! inheres in professional antigen presenting cell [Term] id: OBA:0003715 @@ -134210,8 +233561,8 @@ synonym: "rate of complement activation, alternative pathway" EXACT [AUTO:patter is_a: OBA:0002350 ! immune response rate is_a: OBA:VT0002419 ! innate immune response trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006957 ! complement activation, alternative pathway -relationship: inheres_in GO:0006957 ! complement activation, alternative pathway +intersection_of: RO:0000052 GO:0006957 ! inheres in complement activation, alternative pathway +relationship: RO:0000052 GO:0006957 ! inheres in complement activation, alternative pathway [Term] id: OBA:0003716 @@ -134220,8 +233571,8 @@ def: "The rate of a complement activation, classical pathway." [AUTO:patterns/pa synonym: "rate of complement activation, classical pathway" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002350 ! immune response rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006958 ! complement activation, classical pathway -relationship: inheres_in GO:0006958 ! complement activation, classical pathway +intersection_of: RO:0000052 GO:0006958 ! inheres in complement activation, classical pathway +relationship: RO:0000052 GO:0006958 ! inheres in complement activation, classical pathway [Term] id: OBA:0003717 @@ -134231,7 +233582,7 @@ synonym: "organization quality of extraembryonic structure" EXACT [AUTO:patterns is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0000478 ! extraembryonic structure +intersection_of: RO:0000052 UBERON:0000478 ! inheres in extraembryonic structure [Term] id: OBA:0003718 @@ -134241,8 +233592,8 @@ synonym: "amount of extraembryonic ectoderm" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004366 ! extraembryonic ectoderm -relationship: inheres_in UBERON:0004366 ! extraembryonic ectoderm +intersection_of: RO:0000052 UBERON:0004366 ! inheres in extraembryonic ectoderm +relationship: RO:0000052 UBERON:0004366 ! inheres in extraembryonic ectoderm [Term] id: OBA:0003719 @@ -134252,7 +233603,7 @@ synonym: "size of ectoplacental cone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005032 ! ectoplacental cone morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004364 ! ectoplacental cone +intersection_of: RO:0000052 UBERON:0004364 ! inheres in ectoplacental cone [Term] id: OBA:0003720 @@ -134262,7 +233613,7 @@ synonym: "onset quality of neural tube closure" EXACT [AUTO:patterns/patterns/en is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:1000602 ! neural tube closure quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001843 ! neural tube closure +intersection_of: RO:0000052 GO:0001843 ! inheres in neural tube closure [Term] id: OBA:0003721 @@ -134272,7 +233623,7 @@ synonym: "degeneration of post-anal tail" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003693 ! post-anal tail morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0003722 @@ -134282,7 +233633,7 @@ synonym: "size of jaw skeleton" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000454 ! jaw morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001708 ! jaw skeleton +intersection_of: RO:0000052 UBERON:0001708 ! inheres in jaw skeleton [Term] id: OBA:0003723 @@ -134292,8 +233643,8 @@ synonym: "rate of intestinal cholesterol absorption" EXACT [AUTO:patterns/patter is_a: OBA:1000642 ! intestinal absorption quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030299 ! intestinal cholesterol absorption -relationship: inheres_in GO:0030299 ! intestinal cholesterol absorption +intersection_of: RO:0000052 GO:0030299 ! inheres in intestinal cholesterol absorption +relationship: RO:0000052 GO:0030299 ! inheres in intestinal cholesterol absorption [Term] id: OBA:0003724 @@ -134303,7 +233654,7 @@ synonym: "spatial pattern of ameloblast" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003725 ! ameloblast morphology is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in CL:0000059 ! ameloblast +intersection_of: RO:0000052 CL:0000059 ! inheres in ameloblast [Term] id: OBA:0003725 @@ -134312,8 +233663,8 @@ def: "The morphology of a ameloblast." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of ameloblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000059 ! ameloblast -relationship: inheres_in CL:0000059 ! ameloblast +intersection_of: RO:0000052 CL:0000059 ! inheres in ameloblast +relationship: RO:0000052 CL:0000059 ! inheres in ameloblast [Term] id: OBA:0003726 @@ -134323,7 +233674,7 @@ synonym: "size of cardiac muscle tissue of myocardium" EXACT [AUTO:patterns/patt is_a: OBA:0004719 ! cardiac muscle tissue size is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004493 ! cardiac muscle tissue of myocardium +intersection_of: RO:0000052 UBERON:0004493 ! inheres in cardiac muscle tissue of myocardium [Term] id: OBA:0003727 @@ -134333,7 +233684,7 @@ synonym: "size of cartilage tissue" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002418 ! cartilage tissue +intersection_of: RO:0000052 UBERON:0002418 ! inheres in cartilage tissue [Term] id: OBA:0003728 @@ -134343,8 +233694,8 @@ synonym: "amount of blastocele" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000090 ! blastocele -relationship: inheres_in UBERON:0000090 ! blastocele +intersection_of: RO:0000052 UBERON:0000090 ! inheres in blastocele +relationship: RO:0000052 UBERON:0000090 ! inheres in blastocele [Term] id: OBA:0003729 @@ -134354,7 +233705,7 @@ synonym: "rate of flagellated sperm motility" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0002674 ! sperm motility trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030317 ! flagellated sperm motility +intersection_of: RO:0000052 GO:0030317 ! inheres in flagellated sperm motility [Term] id: OBA:0003730 @@ -134364,8 +233715,8 @@ synonym: "amount of trabecula carnea cardiac muscle tissue" EXACT [AUTO:patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003452 ! trabecula carnea cardiac muscle tissue -relationship: inheres_in UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: RO:0000052 UBERON:0003452 ! inheres in trabecula carnea cardiac muscle tissue +relationship: RO:0000052 UBERON:0003452 ! inheres in trabecula carnea cardiac muscle tissue [Term] id: OBA:0003731 @@ -134375,8 +233726,8 @@ synonym: "2-D shape of perinuclear theca" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000013 ! cytoskeleton morphology is_a: PATO:0002006 ! 2-D shape intersection_of: PATO:0002006 ! 2-D shape -intersection_of: inheres_in GO:0033011 ! perinuclear theca -relationship: inheres_in GO:0033011 ! perinuclear theca +intersection_of: RO:0000052 GO:0033011 ! inheres in perinuclear theca +relationship: RO:0000052 GO:0033011 ! inheres in perinuclear theca [Term] id: OBA:0003732 @@ -134386,7 +233737,7 @@ synonym: "opacity of vitreous body" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000686 ! vitreous body quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0001798 ! vitreous body +intersection_of: RO:0000052 UBERON:0001798 ! inheres in vitreous body [Term] id: OBA:0003733 @@ -134396,7 +233747,7 @@ synonym: "rate of glucagon secretion" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003565 ! glucagon secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070091 ! glucagon secretion +intersection_of: RO:0000052 GO:0070091 ! inheres in glucagon secretion [Term] id: OBA:0003734 @@ -134406,7 +233757,7 @@ synonym: "rate of glycogen catabolic process" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0002713 ! glycogen catabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0005980 ! glycogen catabolic process +intersection_of: RO:0000052 GO:0005980 ! inheres in glycogen catabolic process [Term] id: OBA:0003735 @@ -134416,7 +233767,7 @@ synonym: "size of male preputial gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003736 ! male preputial gland morphology is_a: OBA:VT0002716 ! preputial gland size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005301 ! male preputial gland +intersection_of: RO:0000052 UBERON:0005301 ! inheres in male preputial gland [Term] id: OBA:0003736 @@ -134426,8 +233777,8 @@ synonym: "morphology of male preputial gland" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0005813 ! male accessory sex gland morphology is_a: OBA:VT0002717 ! preputial gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005301 ! male preputial gland -relationship: inheres_in UBERON:0005301 ! male preputial gland +intersection_of: RO:0000052 UBERON:0005301 ! inheres in male preputial gland +relationship: RO:0000052 UBERON:0005301 ! inheres in male preputial gland [Term] id: OBA:0003737 @@ -134437,8 +233788,8 @@ synonym: "morphology of hemopoietic organ" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004177 ! hemopoietic organ -relationship: inheres_in UBERON:0004177 ! hemopoietic organ +intersection_of: RO:0000052 UBERON:0004177 ! inheres in hemopoietic organ +relationship: RO:0000052 UBERON:0004177 ! inheres in hemopoietic organ [Term] id: OBA:0003738 @@ -134448,8 +233799,8 @@ synonym: "morphology of dentate gyrus granule cell layer" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005381 ! dentate gyrus granule cell layer -relationship: inheres_in UBERON:0005381 ! dentate gyrus granule cell layer +intersection_of: RO:0000052 UBERON:0005381 ! inheres in dentate gyrus granule cell layer +relationship: RO:0000052 UBERON:0005381 ! inheres in dentate gyrus granule cell layer [Term] id: OBA:0003739 @@ -134459,8 +233810,8 @@ synonym: "displaced of cerebellar granule cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005527 ! neuron displaced is_a: OBA:1000922 ! granule cell quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0001031 ! cerebellar granule cell -relationship: inheres_in CL:0001031 ! cerebellar granule cell +intersection_of: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell +relationship: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell [Term] id: OBA:0003740 @@ -134470,8 +233821,8 @@ synonym: "displaced of Bergmann glial cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002311 ! neural cell displaced is_a: OBA:1000381 ! astrocyte quality intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000644 ! Bergmann glial cell -relationship: inheres_in CL:0000644 ! Bergmann glial cell +intersection_of: RO:0000052 CL:0000644 ! inheres in Bergmann glial cell +relationship: RO:0000052 CL:0000644 ! inheres in Bergmann glial cell [Term] id: OBA:0003741 @@ -134481,8 +233832,8 @@ synonym: "spatial pattern of viscus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002075 ! viscus -relationship: inheres_in UBERON:0002075 ! viscus +intersection_of: RO:0000052 UBERON:0002075 ! inheres in viscus +relationship: RO:0000052 UBERON:0002075 ! inheres in viscus [Term] id: OBA:0003742 @@ -134492,7 +233843,7 @@ synonym: "position of anatomical system" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000467 ! anatomical system +intersection_of: RO:0000052 UBERON:0000467 ! inheres in anatomical system [Term] id: OBA:0003743 @@ -134502,7 +233853,7 @@ synonym: "size of Sertoli cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0002784 ! Sertoli cell morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000216 ! Sertoli cell +intersection_of: RO:0000052 CL:0000216 ! inheres in Sertoli cell [Term] id: OBA:0003744 @@ -134512,7 +233863,7 @@ synonym: "rate of regulation of water loss via skin" EXACT [AUTO:patterns/patter is_a: OBA:VT0002796 ! skin barrier function trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0033561 ! regulation of water loss via skin +intersection_of: RO:0000052 GO:0033561 ! inheres in regulation of water loss via skin [Term] id: OBA:0003745 @@ -134521,8 +233872,8 @@ def: "The rate of a skeletal muscle contraction." [AUTO:patterns/patterns/entity synonym: "rate of skeletal muscle contraction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003544 ! muscle contraction rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0003009 ! skeletal muscle contraction -relationship: inheres_in GO:0003009 ! skeletal muscle contraction +intersection_of: RO:0000052 GO:0003009 ! inheres in skeletal muscle contraction +relationship: RO:0000052 GO:0003009 ! inheres in skeletal muscle contraction [Term] id: OBA:0003746 @@ -134537,7 +233888,7 @@ synonym: "rate of glomerular filtration" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004158 ! renal filtration rate is_a: OBA:1000888 ! glomerular filtration quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0003094 ! glomerular filtration +intersection_of: RO:0000052 GO:0003094 ! inheres in glomerular filtration [Term] id: OBA:0003748 @@ -134547,7 +233898,7 @@ synonym: "degeneration of cochlear ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0003703 ! vestibulocochlear ganglion morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000395 ! cochlear ganglion +intersection_of: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion [Term] id: OBA:0003749 @@ -134556,8 +233907,8 @@ def: "The morphology of a melanocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of melanocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000148 ! melanocyte -relationship: inheres_in CL:0000148 ! melanocyte +intersection_of: RO:0000052 CL:0000148 ! inheres in melanocyte +relationship: RO:0000052 CL:0000148 ! inheres in melanocyte [Term] id: OBA:0003750 @@ -134567,8 +233918,8 @@ synonym: "morphology of pharyngeal arch" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002539 ! pharyngeal arch -relationship: inheres_in UBERON:0002539 ! pharyngeal arch +intersection_of: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch +relationship: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch [Term] id: OBA:0003751 @@ -134578,7 +233929,7 @@ synonym: "color pattern of zone of skin" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003617 ! zone of skin spatial pattern is_a: PATO:0000019 ! color pattern intersection_of: PATO:0000019 ! color pattern -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003752 @@ -134588,7 +233939,7 @@ synonym: "onset quality of wound healing" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000751 ! wound healing quality is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0042060 ! wound healing +intersection_of: RO:0000052 GO:0042060 ! inheres in wound healing [Term] id: OBA:0003753 @@ -134598,8 +233949,8 @@ synonym: "onset quality of synapse assembly" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007416 ! synapse assembly -relationship: inheres_in GO:0007416 ! synapse assembly +intersection_of: RO:0000052 GO:0007416 ! inheres in synapse assembly +relationship: RO:0000052 GO:0007416 ! inheres in synapse assembly [Term] id: OBA:0003754 @@ -134608,19 +233959,18 @@ def: "The morphology of a skeletal joint." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of skeletal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002932 ! joint morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000982 ! skeletal joint -relationship: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint +relationship: RO:0000052 UBERON:0000982 ! inheres in skeletal joint [Term] id: OBA:0003755 name: axon extension involved in axon guidance onset quality def: "The onset quality of a axon extension involved in axon guidance." [AUTO:patterns/patterns/entity_attribute] synonym: "onset quality of axon extension involved in axon guidance" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:0002216 ! growth onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0048846 ! axon extension involved in axon guidance -relationship: inheres_in GO:0048846 ! axon extension involved in axon guidance +intersection_of: RO:0000052 GO:0048846 ! inheres in axon extension involved in axon guidance +relationship: RO:0000052 GO:0048846 ! inheres in axon extension involved in axon guidance [Term] id: OBA:0003756 @@ -134630,8 +233980,8 @@ synonym: "amount of otolith" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002280 ! otolith -relationship: inheres_in UBERON:0002280 ! otolith +intersection_of: RO:0000052 UBERON:0002280 ! inheres in otolith +relationship: RO:0000052 UBERON:0002280 ! inheres in otolith [Term] id: OBA:0003757 @@ -134640,8 +233990,8 @@ def: "The amount of a retinal ganglion cell." [AUTO:patterns/patterns/entity_att synonym: "amount of retinal ganglion cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000740 ! retinal ganglion cell -relationship: inheres_in CL:0000740 ! retinal ganglion cell +intersection_of: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell +relationship: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell [Term] id: OBA:0003758 @@ -134651,7 +234001,7 @@ synonym: "height of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003585 ! ureter size trait is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0003759 @@ -134661,8 +234011,8 @@ synonym: "displaced of thymus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002370 ! thymus -relationship: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus +relationship: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:0003760 @@ -134672,8 +234022,8 @@ synonym: "morphology of cervical vertebra" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000660 ! trunk or cervical vertebra quality is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra -relationship: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra +relationship: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0003761 @@ -134682,8 +234032,8 @@ def: "The morphology of a sacral vertebra." [AUTO:patterns/patterns/entity_attri synonym: "morphology of sacral vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001094 ! sacral vertebra -relationship: inheres_in UBERON:0001094 ! sacral vertebra +intersection_of: RO:0000052 UBERON:0001094 ! inheres in sacral vertebra +relationship: RO:0000052 UBERON:0001094 ! inheres in sacral vertebra [Term] id: OBA:0003762 @@ -134693,8 +234043,8 @@ synonym: "morphology of visceral serous pericardium" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002425 ! visceral serous pericardium -relationship: inheres_in UBERON:0002425 ! visceral serous pericardium +intersection_of: RO:0000052 UBERON:0002425 ! inheres in visceral serous pericardium +relationship: RO:0000052 UBERON:0002425 ! inheres in visceral serous pericardium [Term] id: OBA:0003763 @@ -134703,8 +234053,8 @@ def: "The morphology of a metacarpal bone." [AUTO:patterns/patterns/entity_attri synonym: "morphology of metacarpal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002374 ! metacarpal bone -relationship: inheres_in UBERON:0002374 ! metacarpal bone +intersection_of: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone +relationship: RO:0000052 UBERON:0002374 ! inheres in metacarpal bone [Term] id: OBA:0003764 @@ -134714,8 +234064,8 @@ synonym: "amount of natural killer cell mediated cytotoxicity" EXACT [AUTO:patte is_a: OBA:VT0002419 ! innate immune response trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042267 ! natural killer cell mediated cytotoxicity -relationship: inheres_in GO:0042267 ! natural killer cell mediated cytotoxicity +intersection_of: RO:0000052 GO:0042267 ! inheres in natural killer cell mediated cytotoxicity +relationship: RO:0000052 GO:0042267 ! inheres in natural killer cell mediated cytotoxicity [Term] id: OBA:0003765 @@ -134725,7 +234075,7 @@ synonym: "composition of spinal cord" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000955 ! spinal cord morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002240 ! spinal cord +intersection_of: RO:0000052 UBERON:0002240 ! inheres in spinal cord [Term] id: OBA:0003766 @@ -134735,8 +234085,8 @@ synonym: "amount of allantois" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004340 ! allantois -relationship: inheres_in UBERON:0004340 ! allantois +intersection_of: RO:0000052 UBERON:0004340 ! inheres in allantois +relationship: RO:0000052 UBERON:0004340 ! inheres in allantois [Term] id: OBA:0003767 @@ -134746,8 +234096,8 @@ synonym: "tonicity of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001439 ! tonicity intersection_of: PATO:0001439 ! tonicity -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003768 @@ -134757,7 +234107,7 @@ synonym: "size of substantia propria of cornea" EXACT [AUTO:patterns/patterns/en is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005300 ! corneal stroma morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:0003769 @@ -134767,8 +234117,8 @@ synonym: "flexibility of tendon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0001543 ! flexibility intersection_of: PATO:0001543 ! flexibility -intersection_of: inheres_in UBERON:0000043 ! tendon -relationship: inheres_in UBERON:0000043 ! tendon +intersection_of: RO:0000052 UBERON:0000043 ! inheres in tendon +relationship: RO:0000052 UBERON:0000043 ! inheres in tendon [Term] id: OBA:0003770 @@ -134778,7 +234128,7 @@ synonym: "length of jugal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002054 ! jugal bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001683 ! jugal bone +intersection_of: RO:0000052 UBERON:0001683 ! inheres in jugal bone [Term] id: OBA:0003771 @@ -134788,8 +234138,8 @@ synonym: "amount of malleus processus brevis" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005354 ! malleus processus brevis -relationship: inheres_in UBERON:0005354 ! malleus processus brevis +intersection_of: RO:0000052 UBERON:0005354 ! inheres in malleus processus brevis +relationship: RO:0000052 UBERON:0005354 ! inheres in malleus processus brevis [Term] id: OBA:0003772 @@ -134799,7 +234149,7 @@ synonym: "degree of pigmentation of parathyroid gland" EXACT [AUTO:patterns/patt is_a: OBA:1000109 ! anatomical pigmentation is_a: OBA:VT0000678 ! parathyroid gland morphology trait intersection_of: PATO:0002247 ! degree of pigmentation -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:0003773 @@ -134809,8 +234159,8 @@ synonym: "orientation of urethral opening" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0010418 ! urethral opening -relationship: inheres_in UBERON:0010418 ! urethral opening +intersection_of: RO:0000052 UBERON:0010418 ! inheres in urethral opening +relationship: RO:0000052 UBERON:0010418 ! inheres in urethral opening [Term] id: OBA:0003774 @@ -134819,8 +234169,8 @@ def: "The morphology of a external female genitalia." [AUTO:patterns/patterns/en synonym: "morphology of external female genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004650 ! female reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005056 ! external female genitalia -relationship: inheres_in UBERON:0005056 ! external female genitalia +intersection_of: RO:0000052 UBERON:0005056 ! inheres in external female genitalia +relationship: RO:0000052 UBERON:0005056 ! inheres in external female genitalia [Term] id: OBA:0003775 @@ -134830,7 +234180,7 @@ synonym: "curvature of clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003127 ! clitoris morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002411 ! clitoris +intersection_of: RO:0000052 UBERON:0002411 ! inheres in clitoris [Term] id: OBA:0003776 @@ -134840,7 +234190,7 @@ synonym: "onset quality of cloacal septation" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:1000936 ! cloacal septation quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060197 ! cloacal septation +intersection_of: RO:0000052 GO:0060197 ! inheres in cloacal septation [Term] id: OBA:0003777 @@ -134849,8 +234199,8 @@ def: "The amount of a precursor B cell." [AUTO:patterns/patterns/entity_attribut synonym: "amount of precursor B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002633 ! B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000817 ! precursor B cell -relationship: inheres_in CL:0000817 ! precursor B cell +intersection_of: RO:0000052 CL:0000817 ! inheres in precursor B cell +relationship: RO:0000052 CL:0000817 ! inheres in precursor B cell [Term] id: OBA:0003778 @@ -134859,8 +234209,8 @@ def: "The amount of a early pro-B cell." [AUTO:patterns/patterns/entity_attribut synonym: "amount of early pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004319 ! pro-B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002046 ! early pro-B cell -relationship: inheres_in CL:0002046 ! early pro-B cell +intersection_of: RO:0000052 CL:0002046 ! inheres in early pro-B cell +relationship: RO:0000052 CL:0002046 ! inheres in early pro-B cell [Term] id: OBA:0003779 @@ -134869,8 +234219,8 @@ def: "The amount of a late pro-B cell." [AUTO:patterns/patterns/entity_attribute synonym: "amount of late pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003777 ! precursor B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002048 ! late pro-B cell -relationship: inheres_in CL:0002048 ! late pro-B cell +intersection_of: RO:0000052 CL:0002048 ! inheres in late pro-B cell +relationship: RO:0000052 CL:0002048 ! inheres in late pro-B cell [Term] id: OBA:0003780 @@ -134880,8 +234230,8 @@ synonym: "conductivity of myocardium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0002349 ! myocardium -relationship: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium +relationship: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:0003781 @@ -134891,8 +234241,8 @@ synonym: "amount of pinna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001757 ! pinna -relationship: inheres_in UBERON:0001757 ! pinna +intersection_of: RO:0000052 UBERON:0001757 ! inheres in pinna +relationship: RO:0000052 UBERON:0001757 ! inheres in pinna [Term] id: OBA:0003782 @@ -134902,8 +234252,8 @@ synonym: "amount of cochlear ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000203 ! cranial ganglion quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000395 ! cochlear ganglion -relationship: inheres_in UBERON:0000395 ! cochlear ganglion +intersection_of: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion +relationship: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion [Term] id: OBA:0003783 @@ -134913,8 +234263,8 @@ synonym: "amount of tunnel of Corti" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005972 ! tunnel of Corti -relationship: inheres_in UBERON:0005972 ! tunnel of Corti +intersection_of: RO:0000052 UBERON:0005972 ! inheres in tunnel of Corti +relationship: RO:0000052 UBERON:0005972 ! inheres in tunnel of Corti [Term] id: OBA:0003784 @@ -134925,7 +234275,7 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:0005022 ! chromosome, telomeric region morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region +intersection_of: RO:0000052 GO:0000781 ! inheres in chromosome, telomeric region [Term] id: OBA:0003785 @@ -134935,8 +234285,8 @@ synonym: "rate of relaxation of muscle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0090075 ! relaxation of muscle -relationship: inheres_in GO:0090075 ! relaxation of muscle +intersection_of: RO:0000052 GO:0090075 ! inheres in relaxation of muscle +relationship: RO:0000052 GO:0090075 ! inheres in relaxation of muscle [Term] id: OBA:0003786 @@ -134946,7 +234296,7 @@ synonym: "amount of lateral semicircular canal" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003244 ! semicircular canal amount is_a: OBA:1000835 ! lateral semicircular canal quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001843 ! lateral semicircular canal +intersection_of: RO:0000052 UBERON:0001843 ! inheres in lateral semicircular canal [Term] id: OBA:0003787 @@ -134956,7 +234306,7 @@ synonym: "amount of posterior semicircular canal" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003244 ! semicircular canal amount is_a: OBA:1000780 ! posterior semicircular canal quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001842 ! posterior semicircular canal +intersection_of: RO:0000052 UBERON:0001842 ! inheres in posterior semicircular canal [Term] id: OBA:0003788 @@ -134966,8 +234316,8 @@ synonym: "morphology of scala vestibuli" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001863 ! scala vestibuli -relationship: inheres_in UBERON:0001863 ! scala vestibuli +intersection_of: RO:0000052 UBERON:0001863 ! inheres in scala vestibuli +relationship: RO:0000052 UBERON:0001863 ! inheres in scala vestibuli [Term] id: OBA:0003789 @@ -134977,8 +234327,8 @@ synonym: "functionality of lysosome" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0005764 ! lysosome -relationship: inheres_in GO:0005764 ! lysosome +intersection_of: RO:0000052 GO:0005764 ! inheres in lysosome +relationship: RO:0000052 GO:0005764 ! inheres in lysosome [Term] id: OBA:0003790 @@ -134989,7 +234339,7 @@ is_a: OBA:0003741 ! viscus spatial pattern is_a: OBA:0004776 ! left lung morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002168 ! left lung +intersection_of: RO:0000052 UBERON:0002168 ! inheres in left lung [Term] id: OBA:0003791 @@ -135000,7 +234350,7 @@ is_a: OBA:0003754 ! skeletal joint morphology is_a: OBA:1000205 ! synovial joint quality is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002217 ! synovial joint +intersection_of: RO:0000052 UBERON:0002217 ! inheres in synovial joint [Term] id: OBA:0003792 @@ -135010,8 +234360,8 @@ synonym: "rate of cholesterol efflux" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0033344 ! cholesterol efflux -relationship: inheres_in GO:0033344 ! cholesterol efflux +intersection_of: RO:0000052 GO:0033344 ! inheres in cholesterol efflux +relationship: RO:0000052 GO:0033344 ! inheres in cholesterol efflux [Term] id: OBA:0003793 @@ -135021,7 +234371,7 @@ synonym: "composition of tendon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000105 ! tissue composition is_a: OBA:VT0005503 ! tendon morphology trait intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000043 ! tendon +intersection_of: RO:0000052 UBERON:0000043 ! inheres in tendon [Term] id: OBA:0003794 @@ -135031,7 +234381,7 @@ synonym: "composition of appendage" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0015071 ! appendage morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000026 ! appendage +intersection_of: RO:0000052 UBERON:0000026 ! inheres in appendage [Term] id: OBA:0003795 @@ -135040,8 +234390,8 @@ def: "The rate of a neuron apoptotic process." [AUTO:patterns/patterns/entity_at synonym: "rate of neuron apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004174 ! apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0051402 ! neuron apoptotic process -relationship: inheres_in GO:0051402 ! neuron apoptotic process +intersection_of: RO:0000052 GO:0051402 ! inheres in neuron apoptotic process +relationship: RO:0000052 GO:0051402 ! inheres in neuron apoptotic process [Term] id: OBA:0003796 @@ -135051,7 +234401,7 @@ synonym: "degeneration of neuron" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0002882 ! neuron morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:0003797 @@ -135061,7 +234411,7 @@ synonym: "size of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000051 ! cell projection size is_a: OBA:VT0005404 ! axon morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon [Term] id: OBA:0003798 @@ -135070,8 +234420,8 @@ def: "The morphology of a GABAergic neuron." [AUTO:patterns/patterns/entity_attr synonym: "morphology of GABAergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000617 ! GABAergic neuron -relationship: inheres_in CL:0000617 ! GABAergic neuron +intersection_of: RO:0000052 CL:0000617 ! inheres in GABAergic neuron +relationship: RO:0000052 CL:0000617 ! inheres in GABAergic neuron [Term] id: OBA:0003799 @@ -135080,8 +234430,8 @@ def: "The morphology of a glutamatergic neuron." [AUTO:patterns/patterns/entity_ synonym: "morphology of glutamatergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000679 ! glutamatergic neuron -relationship: inheres_in CL:0000679 ! glutamatergic neuron +intersection_of: RO:0000052 CL:0000679 ! inheres in glutamatergic neuron +relationship: RO:0000052 CL:0000679 ! inheres in glutamatergic neuron [Term] id: OBA:0003800 @@ -135091,18 +234441,19 @@ synonym: "amount of bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002394 ! bile duct -relationship: inheres_in UBERON:0002394 ! bile duct +intersection_of: RO:0000052 UBERON:0002394 ! inheres in bile duct +relationship: RO:0000052 UBERON:0002394 ! inheres in bile duct [Term] id: OBA:0003801 name: external anal sphincter functionality def: "The functionality of a external anal sphincter." [AUTO:patterns/patterns/entity_attribute] synonym: "functionality of external anal sphincter" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0003691 ! muscle organ functionality is_a: OBA:VT0010080 ! skeletal muscle physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001367 ! external anal sphincter -relationship: inheres_in UBERON:0001367 ! external anal sphincter +intersection_of: RO:0000052 UBERON:0001367 ! inheres in external anal sphincter +relationship: RO:0000052 UBERON:0001367 ! inheres in external anal sphincter [Term] id: OBA:0003802 @@ -135112,8 +234463,8 @@ synonym: "position of digestive system element" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0013765 ! digestive system element -relationship: inheres_in UBERON:0013765 ! digestive system element +intersection_of: RO:0000052 UBERON:0013765 ! inheres in digestive system element +relationship: RO:0000052 UBERON:0013765 ! inheres in digestive system element [Term] id: OBA:0003803 @@ -135123,7 +234474,7 @@ synonym: "structure of pylorus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005198 ! pylorus morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001166 ! pylorus +intersection_of: RO:0000052 UBERON:0001166 ! inheres in pylorus [Term] id: OBA:0003804 @@ -135133,7 +234484,7 @@ synonym: "size of exocrine pancreas" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005220 ! exocrine pancreas morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000017 ! exocrine pancreas +intersection_of: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas [Term] id: OBA:0003805 @@ -135143,7 +234494,7 @@ synonym: "rate of ovulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001928 ! ovulation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030728 ! ovulation +intersection_of: RO:0000052 GO:0030728 ! inheres in ovulation [Term] id: OBA:0003806 @@ -135153,7 +234504,7 @@ synonym: "rate of luteinization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003356 ! luteinization trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001553 ! luteinization +intersection_of: RO:0000052 GO:0001553 ! inheres in luteinization [Term] id: OBA:0003807 @@ -135163,7 +234514,7 @@ synonym: "rate of granulosa cell differentiation" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0003357 ! granulosa cell differentiation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060014 ! granulosa cell differentiation +intersection_of: RO:0000052 GO:0060014 ! inheres in granulosa cell differentiation [Term] id: OBA:0003808 @@ -135173,8 +234524,8 @@ synonym: "morphology of hypaxial musculature" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008777 ! hypaxial musculature -relationship: inheres_in UBERON:0008777 ! hypaxial musculature +intersection_of: RO:0000052 UBERON:0008777 ! inheres in hypaxial musculature +relationship: RO:0000052 UBERON:0008777 ! inheres in hypaxial musculature [Term] id: OBA:0003809 @@ -135184,7 +234535,7 @@ synonym: "size of hypaxial musculature" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003808 ! hypaxial musculature morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008777 ! hypaxial musculature +intersection_of: RO:0000052 UBERON:0008777 ! inheres in hypaxial musculature [Term] id: OBA:0003810 @@ -135194,8 +234545,8 @@ synonym: "position of body wall" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000309 ! body wall -relationship: inheres_in UBERON:0000309 ! body wall +intersection_of: RO:0000052 UBERON:0000309 ! inheres in body wall +relationship: RO:0000052 UBERON:0000309 ! inheres in body wall [Term] id: OBA:0003811 @@ -135205,7 +234556,7 @@ synonym: "structure of pericardium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0000288 ! pericardium morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002407 ! pericardium +intersection_of: RO:0000052 UBERON:0002407 ! inheres in pericardium [Term] id: OBA:0003812 @@ -135214,8 +234565,8 @@ def: "The morphology of a subclavian artery." [AUTO:patterns/patterns/entity_att synonym: "morphology of subclavian artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001533 ! subclavian artery -relationship: inheres_in UBERON:0001533 ! subclavian artery +intersection_of: RO:0000052 UBERON:0001533 ! inheres in subclavian artery +relationship: RO:0000052 UBERON:0001533 ! inheres in subclavian artery [Term] id: OBA:0003813 @@ -135230,8 +234581,8 @@ synonym: "amount of placenta labyrinth" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003946 ! placenta labyrinth -relationship: inheres_in UBERON:0003946 ! placenta labyrinth +intersection_of: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth +relationship: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth [Term] id: OBA:0003815 @@ -135241,8 +234592,8 @@ synonym: "amount of zygote asymmetric cell division" EXACT [AUTO:patterns/patter is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0010070 ! zygote asymmetric cell division -relationship: inheres_in GO:0010070 ! zygote asymmetric cell division +intersection_of: RO:0000052 GO:0010070 ! inheres in zygote asymmetric cell division +relationship: RO:0000052 GO:0010070 ! inheres in zygote asymmetric cell division [Term] id: OBA:0003816 @@ -135252,7 +234603,7 @@ synonym: "degeneration of hair follicle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003480 ! hair follicle structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:0003817 @@ -135262,7 +234613,7 @@ synonym: "onset quality of endochondral ossification" EXACT [AUTO:patterns/patte is_a: OBA:0003441 ! ossification onset quality is_a: OBA:1000756 ! endochondral ossification quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001958 ! endochondral ossification +intersection_of: RO:0000052 GO:0001958 ! inheres in endochondral ossification [Term] id: OBA:0003818 @@ -135272,7 +234623,7 @@ synonym: "onset quality of intramembranous ossification" EXACT [AUTO:patterns/pa is_a: OBA:0003441 ! ossification onset quality is_a: OBA:1000670 ! intramembranous ossification quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001957 ! intramembranous ossification +intersection_of: RO:0000052 GO:0001957 ! inheres in intramembranous ossification [Term] id: OBA:0003819 @@ -135282,7 +234633,7 @@ synonym: "rate of fibrinolysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000709 ! fibrinolysis quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042730 ! fibrinolysis +intersection_of: RO:0000052 GO:0042730 ! inheres in fibrinolysis [Term] id: OBA:0003820 @@ -135291,8 +234642,8 @@ def: "The onset quality of a forebrain neuroblast differentiation." [AUTO:patter synonym: "onset quality of forebrain neuroblast differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0021863 ! forebrain neuroblast differentiation -relationship: inheres_in GO:0021863 ! forebrain neuroblast differentiation +intersection_of: RO:0000052 GO:0021863 ! inheres in forebrain neuroblast differentiation +relationship: RO:0000052 GO:0021863 ! inheres in forebrain neuroblast differentiation [Term] id: OBA:0003821 @@ -135302,8 +234653,8 @@ synonym: "rate of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000057 ! gland quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland -relationship: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland +relationship: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:0003822 @@ -135313,8 +234664,8 @@ synonym: "position of seminal vesicle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000057 ! gland quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000998 ! seminal vesicle -relationship: inheres_in UBERON:0000998 ! seminal vesicle +intersection_of: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle +relationship: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle [Term] id: OBA:0003823 @@ -135324,8 +234675,8 @@ synonym: "functionality of carotid body" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001629 ! carotid body -relationship: inheres_in UBERON:0001629 ! carotid body +intersection_of: RO:0000052 UBERON:0001629 ! inheres in carotid body +relationship: RO:0000052 UBERON:0001629 ! inheres in carotid body [Term] id: OBA:0003824 @@ -135334,8 +234685,8 @@ def: "The functionality of a keratinocyte." [AUTO:patterns/patterns/entity_attri synonym: "functionality of keratinocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000312 ! keratinocyte -relationship: inheres_in CL:0000312 ! keratinocyte +intersection_of: RO:0000052 CL:0000312 ! inheres in keratinocyte +relationship: RO:0000052 CL:0000312 ! inheres in keratinocyte [Term] id: OBA:0003825 @@ -135345,8 +234696,8 @@ synonym: "response to of cellular response to stimulus" EXACT [AUTO:patterns/pat is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000077 ! response to intersection_of: PATO:0000077 ! response to -intersection_of: inheres_in GO:0051716 ! cellular response to stimulus -relationship: inheres_in GO:0051716 ! cellular response to stimulus +intersection_of: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus +relationship: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus [Term] id: OBA:0003826 @@ -135356,8 +234707,8 @@ synonym: "threshold of cellular response to stimulus" EXACT [AUTO:patterns/patte is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000152 ! threshold intersection_of: PATO:0000152 ! threshold -intersection_of: inheres_in GO:0051716 ! cellular response to stimulus -relationship: inheres_in GO:0051716 ! cellular response to stimulus +intersection_of: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus +relationship: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus [Term] id: OBA:0003827 @@ -135367,8 +234718,8 @@ synonym: "intensity of cellular response to stimulus" EXACT [AUTO:patterns/patte is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000049 ! intensity intersection_of: PATO:0000049 ! intensity -intersection_of: inheres_in GO:0051716 ! cellular response to stimulus -relationship: inheres_in GO:0051716 ! cellular response to stimulus +intersection_of: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus +relationship: RO:0000052 GO:0051716 ! inheres in cellular response to stimulus [Term] id: OBA:0003828 @@ -135378,7 +234729,7 @@ synonym: "response to of mast cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000179 ! mast cell quality is_a: PATO:0000077 ! response to intersection_of: PATO:0000077 ! response to -intersection_of: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:0003829 @@ -135388,7 +234739,7 @@ synonym: "amount of labium majora" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000533 ! labium majora quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:0003830 @@ -135398,7 +234749,7 @@ synonym: "curvature of labium majora" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003519 ! labia majora shape trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:0003831 @@ -135408,7 +234759,7 @@ synonym: "amount of labium minora" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000344 ! labium minora quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:0003832 @@ -135418,7 +234769,7 @@ synonym: "curvature of labium minora" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003524 ! labia minora shape trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:0003833 @@ -135428,7 +234779,7 @@ synonym: "concavity of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002186 ! vagina shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0003834 @@ -135438,8 +234789,8 @@ synonym: "wetness of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001822 ! wetness intersection_of: PATO:0001822 ! wetness -intersection_of: inheres_in UBERON:0000996 ! vagina -relationship: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina +relationship: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0003835 @@ -135449,8 +234800,8 @@ synonym: "structure of vaginal hymen" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001346 ! vaginal hymen -relationship: inheres_in UBERON:0001346 ! vaginal hymen +intersection_of: RO:0000052 UBERON:0001346 ! inheres in vaginal hymen +relationship: RO:0000052 UBERON:0001346 ! inheres in vaginal hymen [Term] id: OBA:0003836 @@ -135459,8 +234810,8 @@ def: "The morphology of a skin of prepuce of penis." [AUTO:patterns/patterns/ent synonym: "morphology of skin of prepuce of penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001471 ! skin of prepuce of penis -relationship: inheres_in UBERON:0001471 ! skin of prepuce of penis +intersection_of: RO:0000052 UBERON:0001471 ! inheres in skin of prepuce of penis +relationship: RO:0000052 UBERON:0001471 ! inheres in skin of prepuce of penis [Term] id: OBA:0003837 @@ -135470,8 +234821,8 @@ synonym: "amount of vas deferens" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001000 ! vas deferens -relationship: inheres_in UBERON:0001000 ! vas deferens +intersection_of: RO:0000052 UBERON:0001000 ! inheres in vas deferens +relationship: RO:0000052 UBERON:0001000 ! inheres in vas deferens [Term] id: OBA:0003838 @@ -135481,7 +234832,7 @@ synonym: "closure of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001120 ! uterus morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0003839 @@ -135491,7 +234842,7 @@ synonym: "wholeness of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004604 ! uterus structure is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0003840 @@ -135501,7 +234852,7 @@ synonym: "structure of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000534 ! ureter morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0003841 @@ -135511,7 +234862,7 @@ synonym: "concavity of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003650 ! kidney shape trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0003842 @@ -135521,8 +234872,8 @@ synonym: "position of urinary bladder" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001255 ! urinary bladder -relationship: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder +relationship: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:0003843 @@ -135532,7 +234883,7 @@ synonym: "spatial pattern of urachus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1001073 ! urachus morphology is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002068 ! urachus +intersection_of: RO:0000052 UBERON:0002068 ! inheres in urachus [Term] id: OBA:0003844 @@ -135542,7 +234893,7 @@ synonym: "closure of uterine cervix" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0001135 ! cervix morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000002 ! uterine cervix +intersection_of: RO:0000052 UBERON:0000002 ! inheres in uterine cervix [Term] id: OBA:0003845 @@ -135552,7 +234903,7 @@ synonym: "size of renal medulla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003014 ! kidney medulla morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000362 ! renal medulla +intersection_of: RO:0000052 UBERON:0000362 ! inheres in renal medulla [Term] id: OBA:0003846 @@ -135562,7 +234913,7 @@ synonym: "composition of thoracic cavity" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0015045 ! thoracic cavity morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002224 ! thoracic cavity +intersection_of: RO:0000052 UBERON:0002224 ! inheres in thoracic cavity [Term] id: OBA:0003847 @@ -135572,8 +234923,8 @@ synonym: "deviation (from_normal) of long bone epiphyseal plate proliferative zo is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0006771 ! long bone epiphyseal plate proliferative zone -relationship: inheres_in UBERON:0006771 ! long bone epiphyseal plate proliferative zone +intersection_of: RO:0000052 UBERON:0006771 ! inheres in long bone epiphyseal plate proliferative zone +relationship: RO:0000052 UBERON:0006771 ! inheres in long bone epiphyseal plate proliferative zone [Term] id: OBA:0003848 @@ -135583,7 +234934,7 @@ synonym: "rate of sperm capacitation" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003666 ! sperm capacitation trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048240 ! sperm capacitation +intersection_of: RO:0000052 GO:0048240 ! inheres in sperm capacitation [Term] id: OBA:0003849 @@ -135592,8 +234943,8 @@ def: "The morphology of a periodontal ligament." [AUTO:patterns/patterns/entity_ synonym: "morphology of periodontal ligament" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008266 ! periodontal ligament -relationship: inheres_in UBERON:0008266 ! periodontal ligament +intersection_of: RO:0000052 UBERON:0008266 ! inheres in periodontal ligament +relationship: RO:0000052 UBERON:0008266 ! inheres in periodontal ligament [Term] id: OBA:0003850 @@ -135603,7 +234954,7 @@ synonym: "position of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000403 ! lobule of pinna quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:0003851 @@ -135613,7 +234964,7 @@ synonym: "prominence of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003850 ! lobule of pinna position is_a: PATO:0015007 ! prominence intersection_of: PATO:0015007 ! prominence -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:0003852 @@ -135622,8 +234973,8 @@ def: "The strength of a eye muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "strength of eye muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000079 ! muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0004277 ! eye muscle -relationship: inheres_in UBERON:0004277 ! eye muscle +intersection_of: RO:0000052 UBERON:0004277 ! inheres in eye muscle +relationship: RO:0000052 UBERON:0004277 ! inheres in eye muscle [Term] id: OBA:0003853 @@ -135633,8 +234984,8 @@ synonym: "amount of blastocyst hatching" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001835 ! blastocyst hatching -relationship: inheres_in GO:0001835 ! blastocyst hatching +intersection_of: RO:0000052 GO:0001835 ! inheres in blastocyst hatching +relationship: RO:0000052 GO:0001835 ! inheres in blastocyst hatching [Term] id: OBA:0003854 @@ -135644,8 +234995,8 @@ synonym: "onset quality of blastocyst hatching" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001835 ! blastocyst hatching -relationship: inheres_in GO:0001835 ! blastocyst hatching +intersection_of: RO:0000052 GO:0001835 ! inheres in blastocyst hatching +relationship: RO:0000052 GO:0001835 ! inheres in blastocyst hatching [Term] id: OBA:0003855 @@ -135655,7 +235006,7 @@ synonym: "amount of zona pellucida" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000755 ! zona pellucida quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000086 ! zona pellucida +intersection_of: RO:0000052 UBERON:0000086 ! inheres in zona pellucida [Term] id: OBA:0003856 @@ -135665,8 +235016,8 @@ synonym: "morphology of chromosome" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005694 ! chromosome -relationship: inheres_in GO:0005694 ! chromosome +intersection_of: RO:0000052 GO:0005694 ! inheres in chromosome +relationship: RO:0000052 GO:0005694 ! inheres in chromosome [Term] id: OBA:0003857 @@ -135676,8 +235027,8 @@ synonym: "amount of nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005634 ! nucleus -relationship: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus +relationship: RO:0000052 GO:0005634 ! inheres in nucleus [Term] id: OBA:0003858 @@ -135687,7 +235038,7 @@ synonym: "nucleate quality of cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001404 ! nucleate quality intersection_of: PATO:0001404 ! nucleate quality -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0003859 @@ -135697,8 +235048,8 @@ synonym: "deviation (from_normal) of blood vessel remodeling" EXACT [AUTO:patter is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in GO:0001974 ! blood vessel remodeling -relationship: inheres_in GO:0001974 ! blood vessel remodeling +intersection_of: RO:0000052 GO:0001974 ! inheres in blood vessel remodeling +relationship: RO:0000052 GO:0001974 ! inheres in blood vessel remodeling [Term] id: OBA:0003860 @@ -135708,17 +235059,17 @@ synonym: "spatial pattern of external ear" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002845 ! external ear morphology is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:0003861 -name: pericyte cell morphology -def: "The morphology of a pericyte cell." [AUTO:patterns/patterns/entity_attribute] -synonym: "morphology of pericyte cell" EXACT [AUTO:patterns/patterns/entity_attribute] +name: pericyte morphology +def: "The morphology of a pericyte." [AUTO:patterns/patterns/entity_attribute] +synonym: "morphology of pericyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000669 ! pericyte cell -relationship: inheres_in CL:0000669 ! pericyte cell +intersection_of: RO:0000052 CL:0000669 ! inheres in pericyte cell +relationship: RO:0000052 CL:0000669 ! inheres in pericyte cell [Term] id: OBA:0003862 @@ -135728,8 +235079,8 @@ synonym: "deviation (from_normal) of photoreceptor layer of retina" EXACT [AUTO: is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0001787 ! photoreceptor layer of retina -relationship: inheres_in UBERON:0001787 ! photoreceptor layer of retina +intersection_of: RO:0000052 UBERON:0001787 ! inheres in photoreceptor layer of retina +relationship: RO:0000052 UBERON:0001787 ! inheres in photoreceptor layer of retina [Term] id: OBA:0003863 @@ -135739,7 +235090,7 @@ synonym: "mass density of auditory ossicle bone" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000265 ! auditory ossicle bone quality is_a: OBA:VT0005007 ! bone mineral mass intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001686 ! auditory ossicle bone +intersection_of: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone [Term] id: OBA:0003864 @@ -135749,7 +235100,7 @@ synonym: "structure of auditory ossicle bone" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0005105 ! auditory ossicle morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001686 ! auditory ossicle bone +intersection_of: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone [Term] id: OBA:0003865 @@ -135759,7 +235110,7 @@ synonym: "concavity of secondary palate" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004894 ! secondary palate shape is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:0003866 @@ -135769,8 +235120,8 @@ synonym: "functionality of immune organ" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005057 ! immune organ -relationship: inheres_in UBERON:0005057 ! immune organ +intersection_of: RO:0000052 UBERON:0005057 ! inheres in immune organ +relationship: RO:0000052 UBERON:0005057 ! inheres in immune organ [Term] id: OBA:0003867 @@ -135780,7 +235131,7 @@ synonym: "spatial pattern of lip" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0003769 ! lip morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:0003868 @@ -135790,7 +235141,7 @@ synonym: "size of lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003769 ! lip morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:0003869 @@ -135800,7 +235151,7 @@ synonym: "height of lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003868 ! lip size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:0003870 @@ -135809,8 +235160,8 @@ def: "The onset quality of a aging." [AUTO:patterns/patterns/entity_attribute] synonym: "onset quality of aging" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007568 ! aging -relationship: inheres_in GO:0007568 ! aging +intersection_of: RO:0000052 GO:0007568 ! inheres in aging +relationship: RO:0000052 GO:0007568 ! inheres in aging [Term] id: OBA:0003871 @@ -135820,7 +235171,7 @@ synonym: "onset quality of somite development" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0001688 ! somite development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0061053 ! somite development +intersection_of: RO:0000052 GO:0061053 ! inheres in somite development [Term] id: OBA:0003872 @@ -135830,8 +235181,8 @@ synonym: "rate of macrophage chemotaxis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005567 ! cell chemotaxis rate is_a: OBA:VT0003156 ! leukocyte migration trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048246 ! macrophage chemotaxis -relationship: inheres_in GO:0048246 ! macrophage chemotaxis +intersection_of: RO:0000052 GO:0048246 ! inheres in macrophage chemotaxis +relationship: RO:0000052 GO:0048246 ! inheres in macrophage chemotaxis [Term] id: OBA:0003873 @@ -135840,8 +235191,8 @@ def: "The morphology of a type II cell of adrenal medulla." [AUTO:patterns/patte synonym: "morphology of type II cell of adrenal medulla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005268 ! neuroendocrine cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002082 ! type II cell of adrenal medulla -relationship: inheres_in CL:0002082 ! type II cell of adrenal medulla +intersection_of: RO:0000052 CL:0002082 ! inheres in type II cell of adrenal medulla +relationship: RO:0000052 CL:0002082 ! inheres in type II cell of adrenal medulla [Term] id: OBA:0003874 @@ -135851,7 +235202,7 @@ synonym: "structure of coat of hair" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003645 ! coat of hair morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair [Term] id: OBA:0003875 @@ -135861,7 +235212,7 @@ synonym: "fragility of strand of hair" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002331 ! strand of hair structure is_a: PATO:0001662 ! fragility intersection_of: PATO:0001662 ! fragility -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:0003876 @@ -135871,7 +235222,7 @@ synonym: "water composition of zone of skin" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003673 ! zone of skin composition is_a: PATO:0001800 ! water composition intersection_of: PATO:0001800 ! water composition -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:0003877 @@ -135881,8 +235232,8 @@ synonym: "rate of defecation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030421 ! defecation -relationship: inheres_in GO:0030421 ! defecation +intersection_of: RO:0000052 GO:0030421 ! inheres in defecation +relationship: RO:0000052 GO:0030421 ! inheres in defecation [Term] id: OBA:0003878 @@ -135892,8 +235243,8 @@ synonym: "composition of feces" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001988 ! feces -relationship: inheres_in UBERON:0001988 ! feces +intersection_of: RO:0000052 UBERON:0001988 ! inheres in feces +relationship: RO:0000052 UBERON:0001988 ! inheres in feces [Term] id: OBA:0003879 @@ -135903,8 +235254,8 @@ synonym: "displaced of cartilage tissue" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002418 ! cartilage tissue -relationship: inheres_in UBERON:0002418 ! cartilage tissue +intersection_of: RO:0000052 UBERON:0002418 ! inheres in cartilage tissue +relationship: RO:0000052 UBERON:0002418 ! inheres in cartilage tissue [Term] id: OBA:0003880 @@ -135914,8 +235265,8 @@ synonym: "morphology of myelin sheath" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0043209 ! myelin sheath -relationship: inheres_in GO:0043209 ! myelin sheath +intersection_of: RO:0000052 GO:0043209 ! inheres in myelin sheath +relationship: RO:0000052 GO:0043209 ! inheres in myelin sheath [Term] id: OBA:0003881 @@ -135925,7 +235276,7 @@ synonym: "size of pharyngeal arch" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002539 ! pharyngeal arch +intersection_of: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch [Term] id: OBA:0003882 @@ -135935,8 +235286,8 @@ synonym: "amount of pharyngeal arch" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002539 ! pharyngeal arch -relationship: inheres_in UBERON:0002539 ! pharyngeal arch +intersection_of: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch +relationship: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch [Term] id: OBA:0003883 @@ -135946,7 +235297,7 @@ synonym: "rate of hepatocyte proliferation" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003479 ! cell population proliferation rate is_a: OBA:VT0003893 ! hepatocyte proliferation trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0072574 ! hepatocyte proliferation +intersection_of: RO:0000052 GO:0072574 ! inheres in hepatocyte proliferation [Term] id: OBA:0003885 @@ -135956,8 +235307,8 @@ synonym: "position of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:0003886 @@ -135967,8 +235318,8 @@ synonym: "rate of glucose import" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0046323 ! glucose import -relationship: inheres_in GO:0046323 ! glucose import +intersection_of: RO:0000052 GO:0046323 ! inheres in glucose import +relationship: RO:0000052 GO:0046323 ! inheres in glucose import [Term] id: OBA:0003887 @@ -135978,8 +235329,8 @@ synonym: "amount of glucose import" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0046323 ! glucose import -relationship: inheres_in GO:0046323 ! glucose import +intersection_of: RO:0000052 GO:0046323 ! inheres in glucose import +relationship: RO:0000052 GO:0046323 ! inheres in glucose import [Term] id: OBA:0003888 @@ -135989,8 +235340,8 @@ synonym: "variability of heart contraction" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001303 ! variability intersection_of: PATO:0001303 ! variability -intersection_of: inheres_in GO:0060047 ! heart contraction -relationship: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction +relationship: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:0003889 @@ -136000,7 +235351,7 @@ synonym: "morphology of odontoid tissue" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000260 ! odontoid tissue quality is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010365 ! odontoid tissue +intersection_of: RO:0000052 UBERON:0010365 ! inheres in odontoid tissue [Term] id: OBA:0003890 @@ -136010,8 +235361,8 @@ synonym: "onset quality of in utero embryonic development" EXACT [AUTO:patterns/ is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0005380 ! embryonic development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001701 ! in utero embryonic development -relationship: inheres_in GO:0001701 ! in utero embryonic development +intersection_of: RO:0000052 GO:0001701 ! inheres in in utero embryonic development +relationship: RO:0000052 GO:0001701 ! inheres in in utero embryonic development [Term] id: OBA:0003891 @@ -136021,7 +235372,7 @@ synonym: "organization quality of embryonic tissue" EXACT [AUTO:patterns/pattern is_a: OBA:0003689 ! embryonic tissue morphology is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0005291 ! embryonic tissue +intersection_of: RO:0000052 UBERON:0005291 ! inheres in embryonic tissue [Term] id: OBA:0003892 @@ -136031,7 +235382,7 @@ synonym: "rate of neurotransmitter secretion" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0005445 ! neurotransmitter release trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007269 ! neurotransmitter secretion +intersection_of: RO:0000052 GO:0007269 ! inheres in neurotransmitter secretion [Term] id: OBA:0003893 @@ -136040,8 +235391,8 @@ def: "The morphology of a uterine artery." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of uterine artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002493 ! uterine artery -relationship: inheres_in UBERON:0002493 ! uterine artery +intersection_of: RO:0000052 UBERON:0002493 ! inheres in uterine artery +relationship: RO:0000052 UBERON:0002493 ! inheres in uterine artery [Term] id: OBA:0003894 @@ -136050,8 +235401,8 @@ def: "The rate of a hemocyte proliferation." [AUTO:patterns/patterns/entity_attr synonym: "rate of hemocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0035172 ! hemocyte proliferation -relationship: inheres_in GO:0035172 ! hemocyte proliferation +intersection_of: RO:0000052 GO:0035172 ! inheres in hemocyte proliferation +relationship: RO:0000052 GO:0035172 ! inheres in hemocyte proliferation [Term] id: OBA:0003895 @@ -136060,8 +235411,8 @@ def: "The functionality of a blood vessel endothelial cell." [AUTO:patterns/patt synonym: "functionality of blood vessel endothelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000071 ! blood vessel endothelial cell -relationship: inheres_in CL:0000071 ! blood vessel endothelial cell +intersection_of: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell +relationship: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell [Term] id: OBA:0003896 @@ -136071,7 +235422,7 @@ synonym: "closure of ductus venosus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004198 ! vein closure is_a: OBA:0005983 ! ductus venosus morphology intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002083 ! ductus venosus +intersection_of: RO:0000052 UBERON:0002083 ! inheres in ductus venosus [Term] id: OBA:0003897 @@ -136080,8 +235431,8 @@ def: "The rate of a intestine smooth muscle contraction." [AUTO:patterns/pattern synonym: "rate of intestine smooth muscle contraction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003545 ! smooth muscle contraction rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0014827 ! intestine smooth muscle contraction -relationship: inheres_in GO:0014827 ! intestine smooth muscle contraction +intersection_of: RO:0000052 GO:0014827 ! inheres in intestine smooth muscle contraction +relationship: RO:0000052 GO:0014827 ! inheres in intestine smooth muscle contraction [Term] id: OBA:0003898 @@ -136096,8 +235447,8 @@ synonym: "amount of chromosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005694 ! chromosome -relationship: inheres_in GO:0005694 ! chromosome +intersection_of: RO:0000052 GO:0005694 ! inheres in chromosome +relationship: RO:0000052 GO:0005694 ! inheres in chromosome [Term] id: OBA:0003900 @@ -136107,7 +235458,7 @@ synonym: "ploidy of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001374 ! ploidy intersection_of: PATO:0001374 ! ploidy -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:0003901 @@ -136117,8 +235468,8 @@ synonym: "deviation (from_normal) of interventricular groove" EXACT [AUTO:patter is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0005455 ! interventricular groove -relationship: inheres_in UBERON:0005455 ! interventricular groove +intersection_of: RO:0000052 UBERON:0005455 ! inheres in interventricular groove +relationship: RO:0000052 UBERON:0005455 ! inheres in interventricular groove [Term] id: OBA:0003902 @@ -136128,8 +235479,8 @@ synonym: "amount of relaxation of muscle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0090075 ! relaxation of muscle -relationship: inheres_in GO:0090075 ! relaxation of muscle +intersection_of: RO:0000052 GO:0090075 ! inheres in relaxation of muscle +relationship: RO:0000052 GO:0090075 ! inheres in relaxation of muscle [Term] id: OBA:0003903 @@ -136139,7 +235490,7 @@ synonym: "shape of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000272 ! aorta morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:0003904 @@ -136149,7 +235500,7 @@ synonym: "size of myocardial compact layer" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000058 ! heart muscle compact layer morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004125 ! myocardial compact layer +intersection_of: RO:0000052 UBERON:0004125 ! inheres in myocardial compact layer [Term] id: OBA:0003905 @@ -136159,8 +235510,8 @@ synonym: "amount of papillary muscle of heart" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002494 ! papillary muscle of heart -relationship: inheres_in UBERON:0002494 ! papillary muscle of heart +intersection_of: RO:0000052 UBERON:0002494 ! inheres in papillary muscle of heart +relationship: RO:0000052 UBERON:0002494 ! inheres in papillary muscle of heart [Term] id: OBA:0003906 @@ -136170,7 +235521,7 @@ synonym: "size of papillary muscle of heart" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000063 ! ventricle papillary muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002494 ! papillary muscle of heart +intersection_of: RO:0000052 UBERON:0002494 ! inheres in papillary muscle of heart [Term] id: OBA:0003907 @@ -136180,8 +235531,8 @@ synonym: "morphology of trabecula carnea" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002511 ! trabecula carnea -relationship: inheres_in UBERON:0002511 ! trabecula carnea +intersection_of: RO:0000052 UBERON:0002511 ! inheres in trabecula carnea +relationship: RO:0000052 UBERON:0002511 ! inheres in trabecula carnea [Term] id: OBA:0003908 @@ -136191,7 +235542,7 @@ synonym: "size of pair of dorsal aortae" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004068 ! pair of dorsal aortae morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010190 ! pair of dorsal aortae +intersection_of: RO:0000052 UBERON:0010190 ! inheres in pair of dorsal aortae [Term] id: OBA:0003909 @@ -136201,7 +235552,7 @@ synonym: "size of sarcoplasmic reticulum" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000057 ! cellular component size is_a: OBA:VT0004088 ! sarcoplasmic reticulum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0016529 ! sarcoplasmic reticulum +intersection_of: RO:0000052 GO:0016529 ! inheres in sarcoplasmic reticulum [Term] id: OBA:0003910 @@ -136211,7 +235562,7 @@ synonym: "amount of Z disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000701 ! Z disc quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0030018 ! Z disc +intersection_of: RO:0000052 GO:0030018 ! inheres in Z disc [Term] id: OBA:0003911 @@ -136221,7 +235572,7 @@ synonym: "texture of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001312 ! cornea morphology trait is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:0003912 @@ -136230,8 +235581,8 @@ def: "The morphology of a arteriole." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of arteriole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001980 ! arteriole -relationship: inheres_in UBERON:0001980 ! arteriole +intersection_of: RO:0000052 UBERON:0001980 ! inheres in arteriole +relationship: RO:0000052 UBERON:0001980 ! inheres in arteriole [Term] id: OBA:0003913 @@ -136241,7 +235592,7 @@ synonym: "morphology of arch of aorta" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000463 ! arch of aorta quality is_a: OBA:VT0010567 ! thoracic aorta morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:0003914 @@ -136251,8 +235602,8 @@ synonym: "conductivity of bundle of His" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0002353 ! bundle of His -relationship: inheres_in UBERON:0002353 ! bundle of His +intersection_of: RO:0000052 UBERON:0002353 ! inheres in bundle of His +relationship: RO:0000052 UBERON:0002353 ! inheres in bundle of His [Term] id: OBA:0003915 @@ -136261,8 +235612,8 @@ def: "The morphology of a venule." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of venule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001979 ! venule -relationship: inheres_in UBERON:0001979 ! venule +intersection_of: RO:0000052 UBERON:0001979 ! inheres in venule +relationship: RO:0000052 UBERON:0001979 ! inheres in venule [Term] id: OBA:0003916 @@ -136272,7 +235623,7 @@ synonym: "size of hypodermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003705 ! hypodermis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002072 ! hypodermis +intersection_of: RO:0000052 UBERON:0002072 ! inheres in hypodermis [Term] id: OBA:0003917 @@ -136282,8 +235633,8 @@ synonym: "morphology of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001443 ! chest -relationship: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest +relationship: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:0003918 @@ -136292,8 +235643,8 @@ def: "The morphology of a surface mucosal cell of stomach." [AUTO:patterns/patte synonym: "morphology of surface mucosal cell of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002182 ! surface mucosal cell of stomach -relationship: inheres_in CL:0002182 ! surface mucosal cell of stomach +intersection_of: RO:0000052 CL:0002182 ! inheres in surface mucosal cell of stomach +relationship: RO:0000052 CL:0002182 ! inheres in surface mucosal cell of stomach [Term] id: OBA:0003919 @@ -136302,8 +235653,8 @@ def: "The morphology of a parietal cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of parietal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000162 ! parietal cell -relationship: inheres_in CL:0000162 ! parietal cell +intersection_of: RO:0000052 CL:0000162 ! inheres in parietal cell +relationship: RO:0000052 CL:0000162 ! inheres in parietal cell [Term] id: OBA:0003920 @@ -136312,8 +235663,8 @@ def: "The morphology of a peptic cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of peptic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000155 ! peptic cell -relationship: inheres_in CL:0000155 ! peptic cell +intersection_of: RO:0000052 CL:0000155 ! inheres in peptic cell +relationship: RO:0000052 CL:0000155 ! inheres in peptic cell [Term] id: OBA:0003921 @@ -136323,7 +235674,7 @@ synonym: "amount of M band" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000882 ! M band quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0031430 ! M band +intersection_of: RO:0000052 GO:0031430 ! inheres in M band [Term] id: OBA:0003922 @@ -136333,7 +235684,7 @@ synonym: "closure of arch of aorta" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003913 ! arch of aorta morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:0003923 @@ -136343,7 +235694,7 @@ synonym: "shape of arch of aorta" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003913 ! arch of aorta morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:0003924 @@ -136353,8 +235704,8 @@ synonym: "morphology of limbic system development" EXACT [AUTO:patterns/patterns is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0021761 ! limbic system development -relationship: inheres_in GO:0021761 ! limbic system development +intersection_of: RO:0000052 GO:0021761 ! inheres in limbic system development +relationship: RO:0000052 GO:0021761 ! inheres in limbic system development [Term] id: OBA:0003925 @@ -136364,8 +235715,8 @@ synonym: "morphology of parahippocampal gyrus development" EXACT [AUTO:patterns/ is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0021770 ! parahippocampal gyrus development -relationship: inheres_in GO:0021770 ! parahippocampal gyrus development +intersection_of: RO:0000052 GO:0021770 ! inheres in parahippocampal gyrus development +relationship: RO:0000052 GO:0021770 ! inheres in parahippocampal gyrus development [Term] id: OBA:0003926 @@ -136374,8 +235725,8 @@ def: "The morphology of a carotid artery segment." [AUTO:patterns/patterns/entit synonym: "morphology of carotid artery segment" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005396 ! carotid artery segment -relationship: inheres_in UBERON:0005396 ! carotid artery segment +intersection_of: RO:0000052 UBERON:0005396 ! inheres in carotid artery segment +relationship: RO:0000052 UBERON:0005396 ! inheres in carotid artery segment [Term] id: OBA:0003927 @@ -136384,8 +235735,8 @@ def: "The functionality of a pressoreceptor cell." [AUTO:patterns/patterns/entit synonym: "functionality of pressoreceptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004983 ! sensory neuron functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000602 ! pressoreceptor cell -relationship: inheres_in CL:0000602 ! pressoreceptor cell +intersection_of: RO:0000052 CL:0000602 ! inheres in pressoreceptor cell +relationship: RO:0000052 CL:0000602 ! inheres in pressoreceptor cell [Term] id: OBA:0003928 @@ -136395,7 +235746,7 @@ synonym: "concavity of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000277 ! heart shape trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:0003929 @@ -136405,7 +235756,7 @@ synonym: "size of late embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000606 ! late embryo quality is_a: OBA:VT0001697 ! embryo size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000323 ! late embryo +intersection_of: RO:0000052 UBERON:0000323 ! inheres in late embryo [Term] id: OBA:0003930 @@ -136415,8 +235766,8 @@ synonym: "deviation (from_normal) of cephalic midbrain flexure" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0005818 ! cephalic midbrain flexure -relationship: inheres_in UBERON:0005818 ! cephalic midbrain flexure +intersection_of: RO:0000052 UBERON:0005818 ! inheres in cephalic midbrain flexure +relationship: RO:0000052 UBERON:0005818 ! inheres in cephalic midbrain flexure [Term] id: OBA:0003931 @@ -136426,8 +235777,8 @@ synonym: "morphology of diaphysis proper" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006861 ! diaphysis proper -relationship: inheres_in UBERON:0006861 ! diaphysis proper +intersection_of: RO:0000052 UBERON:0006861 ! inheres in diaphysis proper +relationship: RO:0000052 UBERON:0006861 ! inheres in diaphysis proper [Term] id: OBA:0003932 @@ -136436,8 +235787,8 @@ def: "The functionality of a cardiac muscle cell." [AUTO:patterns/patterns/entit synonym: "functionality of cardiac muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell -relationship: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell +relationship: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:0003933 @@ -136447,8 +235798,8 @@ synonym: "deviation (from_normal) of iridocorneal angle" EXACT [AUTO:patterns/pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0006206 ! iridocorneal angle -relationship: inheres_in UBERON:0006206 ! iridocorneal angle +intersection_of: RO:0000052 UBERON:0006206 ! inheres in iridocorneal angle +relationship: RO:0000052 UBERON:0006206 ! inheres in iridocorneal angle [Term] id: OBA:0003934 @@ -136458,8 +235809,8 @@ synonym: "amount of eye trabecular meshwork" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005969 ! eye trabecular meshwork -relationship: inheres_in UBERON:0005969 ! eye trabecular meshwork +intersection_of: RO:0000052 UBERON:0005969 ! inheres in eye trabecular meshwork +relationship: RO:0000052 UBERON:0005969 ! inheres in eye trabecular meshwork [Term] id: OBA:0003936 @@ -136469,8 +235820,8 @@ synonym: "amount of pterygoid muscle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000322 ! masticatory muscle quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006720 ! pterygoid muscle -relationship: inheres_in UBERON:0006720 ! pterygoid muscle +intersection_of: RO:0000052 UBERON:0006720 ! inheres in pterygoid muscle +relationship: RO:0000052 UBERON:0006720 ! inheres in pterygoid muscle [Term] id: OBA:0003937 @@ -136480,8 +235831,8 @@ synonym: "morphology of epaxial musculature" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008778 ! epaxial musculature -relationship: inheres_in UBERON:0008778 ! epaxial musculature +intersection_of: RO:0000052 UBERON:0008778 ! inheres in epaxial musculature +relationship: RO:0000052 UBERON:0008778 ! inheres in epaxial musculature [Term] id: OBA:0003938 @@ -136491,8 +235842,8 @@ synonym: "amount of heart looping" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001947 ! heart looping -relationship: inheres_in GO:0001947 ! heart looping +intersection_of: RO:0000052 GO:0001947 ! inheres in heart looping +relationship: RO:0000052 GO:0001947 ! inheres in heart looping [Term] id: OBA:0003939 @@ -136502,7 +235853,7 @@ synonym: "concavity of atrium auricular region" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0000024 ! atrium appendage morphology trait is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0006618 ! atrium auricular region +intersection_of: RO:0000052 UBERON:0006618 ! inheres in atrium auricular region [Term] id: OBA:0003940 @@ -136512,8 +235863,8 @@ synonym: "morphology of spongiotrophoblast layer" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004021 ! spongiotrophoblast layer -relationship: inheres_in UBERON:0004021 ! spongiotrophoblast layer +intersection_of: RO:0000052 UBERON:0004021 ! inheres in spongiotrophoblast layer +relationship: RO:0000052 UBERON:0004021 ! inheres in spongiotrophoblast layer [Term] id: OBA:0003941 @@ -136523,7 +235874,7 @@ synonym: "strength of multicellular organism" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0010454 ! organism trait is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0003942 @@ -136533,7 +235884,7 @@ synonym: "color saturation of placenta" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000620 ! placenta quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:0003943 @@ -136548,8 +235899,8 @@ synonym: "morphology of lateral ventricle subependymal layer" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010404 ! lateral ventricle subependymal layer -relationship: inheres_in UBERON:0010404 ! lateral ventricle subependymal layer +intersection_of: RO:0000052 UBERON:0010404 ! inheres in lateral ventricle subependymal layer +relationship: RO:0000052 UBERON:0010404 ! inheres in lateral ventricle subependymal layer [Term] id: OBA:0003945 @@ -136559,7 +235910,7 @@ synonym: "amount of Descemet's membrane" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000439 ! Descemet's membrane quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004367 ! Descemet's membrane +intersection_of: RO:0000052 UBERON:0004367 ! inheres in Descemet's membrane [Term] id: OBA:0003946 @@ -136569,7 +235920,7 @@ synonym: "degeneration of vestibular ganglion" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0002856 ! vestibular ganglion morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002824 ! vestibular ganglion +intersection_of: RO:0000052 UBERON:0002824 ! inheres in vestibular ganglion [Term] id: OBA:0003947 @@ -136579,8 +235930,8 @@ synonym: "amount of organ of Corti supporting cell" EXACT [AUTO:patterns/pattern is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002490 ! organ of Corti supporting cell -relationship: inheres_in CL:0002490 ! organ of Corti supporting cell +intersection_of: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell +relationship: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell [Term] id: OBA:0003948 @@ -136590,8 +235941,8 @@ synonym: "morphology of osseus cochlear canal" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006495 ! osseus cochlear canal -relationship: inheres_in UBERON:0006495 ! osseus cochlear canal +intersection_of: RO:0000052 UBERON:0006495 ! inheres in osseus cochlear canal +relationship: RO:0000052 UBERON:0006495 ! inheres in osseus cochlear canal [Term] id: OBA:0003949 @@ -136601,7 +235952,7 @@ synonym: "size of osseus cochlear canal" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003948 ! osseus cochlear canal morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006495 ! osseus cochlear canal +intersection_of: RO:0000052 UBERON:0006495 ! inheres in osseus cochlear canal [Term] id: OBA:0003950 @@ -136611,8 +235962,8 @@ synonym: "amount of ear vesicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003051 ! ear vesicle -relationship: inheres_in UBERON:0003051 ! ear vesicle +intersection_of: RO:0000052 UBERON:0003051 ! inheres in ear vesicle +relationship: RO:0000052 UBERON:0003051 ! inheres in ear vesicle [Term] id: OBA:0003951 @@ -136622,8 +235973,8 @@ synonym: "amount of vestibulocochlear ganglion" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000203 ! cranial ganglion quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002827 ! vestibulocochlear ganglion -relationship: inheres_in UBERON:0002827 ! vestibulocochlear ganglion +intersection_of: RO:0000052 UBERON:0002827 ! inheres in vestibulocochlear ganglion +relationship: RO:0000052 UBERON:0002827 ! inheres in vestibulocochlear ganglion [Term] id: OBA:0003952 @@ -136633,8 +235984,8 @@ synonym: "amount of externally connecting tube lumen" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001349 ! externally connecting tube lumen -relationship: inheres_in UBERON:0001349 ! externally connecting tube lumen +intersection_of: RO:0000052 UBERON:0001349 ! inheres in externally connecting tube lumen +relationship: RO:0000052 UBERON:0001349 ! inheres in externally connecting tube lumen [Term] id: OBA:0003953 @@ -136644,7 +235995,7 @@ synonym: "degeneration of vestibular hair cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0002623 ! vestibular hair cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000609 ! vestibular hair cell +intersection_of: RO:0000052 CL:0000609 ! inheres in vestibular hair cell [Term] id: OBA:0003954 @@ -136653,8 +236004,8 @@ def: "The amount of a vestibular hair cell." [AUTO:patterns/patterns/entity_attr synonym: "amount of vestibular hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003577 ! sensory neuron amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000609 ! vestibular hair cell -relationship: inheres_in CL:0000609 ! vestibular hair cell +intersection_of: RO:0000052 CL:0000609 ! inheres in vestibular hair cell +relationship: RO:0000052 CL:0000609 ! inheres in vestibular hair cell [Term] id: OBA:0003955 @@ -136664,7 +236015,7 @@ synonym: "degeneration of saccule of membranous labyrinth" EXACT [AUTO:patterns/ is_a: OBA:VT0006089 ! saccule morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001854 ! saccule of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001854 ! inheres in saccule of membranous labyrinth [Term] id: OBA:0003956 @@ -136674,7 +236025,7 @@ synonym: "degeneration of macula of saccule of membranous labyrinth" EXACT [AUTO is_a: OBA:VT0004330 ! saccular macula morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002212 ! macula of saccule of membranous labyrinth +intersection_of: RO:0000052 UBERON:0002212 ! inheres in macula of saccule of membranous labyrinth [Term] id: OBA:0003957 @@ -136684,7 +236035,7 @@ synonym: "degeneration of utricle of membranous labyrinth" EXACT [AUTO:patterns/ is_a: OBA:VT0006090 ! utricle morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001853 ! utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth [Term] id: OBA:0003958 @@ -136694,7 +236045,7 @@ synonym: "degeneration of macula of utricle of membranous labyrinth" EXACT [AUTO is_a: OBA:VT0004333 ! utricular macula morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002214 ! macula of utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0002214 ! inheres in macula of utricle of membranous labyrinth [Term] id: OBA:0003959 @@ -136704,7 +236055,7 @@ synonym: "structure of scapula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000149 ! scapula morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0006849 ! scapula +intersection_of: RO:0000052 UBERON:0006849 ! inheres in scapula [Term] id: OBA:0003960 @@ -136714,8 +236065,8 @@ synonym: "amount of acromion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002497 ! acromion -relationship: inheres_in UBERON:0002497 ! acromion +intersection_of: RO:0000052 UBERON:0002497 ! inheres in acromion +relationship: RO:0000052 UBERON:0002497 ! inheres in acromion [Term] id: OBA:0003961 @@ -136725,7 +236076,7 @@ synonym: "degeneration of auditory hair cell" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0002622 ! cochlear hair cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000202 ! auditory hair cell +intersection_of: RO:0000052 CL:0000202 ! inheres in auditory hair cell [Term] id: OBA:0003962 @@ -136735,7 +236086,7 @@ synonym: "degeneration of stria vascularis of cochlear duct" EXACT [AUTO:pattern is_a: OBA:VT0000048 ! stria vascularis morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002282 ! stria vascularis of cochlear duct +intersection_of: RO:0000052 UBERON:0002282 ! inheres in stria vascularis of cochlear duct [Term] id: OBA:0003963 @@ -136745,8 +236096,8 @@ synonym: "amount of utricle of membranous labyrinth" EXACT [AUTO:patterns/patter is_a: OBA:1000782 ! otolith organ quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001853 ! utricle of membranous labyrinth -relationship: inheres_in UBERON:0001853 ! utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth +relationship: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth [Term] id: OBA:0003964 @@ -136756,7 +236107,7 @@ synonym: "structure of tetrapod frontal bone" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000107 ! frontal bone morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000209 ! tetrapod frontal bone +intersection_of: RO:0000052 UBERON:0000209 ! inheres in tetrapod frontal bone [Term] id: OBA:0003965 @@ -136766,7 +236117,7 @@ synonym: "length of tetrapod frontal bone" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002643 ! tetrapod frontal bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000209 ! tetrapod frontal bone +intersection_of: RO:0000052 UBERON:0000209 ! inheres in tetrapod frontal bone [Term] id: OBA:0003966 @@ -136776,7 +236127,7 @@ synonym: "size of interparietal bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000077 ! interparietal bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002229 ! interparietal bone +intersection_of: RO:0000052 UBERON:0002229 ! inheres in interparietal bone [Term] id: OBA:0003967 @@ -136786,8 +236137,8 @@ synonym: "amount of prechordal plate" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003063 ! prechordal plate -relationship: inheres_in UBERON:0003063 ! prechordal plate +intersection_of: RO:0000052 UBERON:0003063 ! inheres in prechordal plate +relationship: RO:0000052 UBERON:0003063 ! inheres in prechordal plate [Term] id: OBA:0003968 @@ -136796,8 +236147,8 @@ def: "The functionality of a CD8-positive, alpha-beta T cell." [AUTO:patterns/pa synonym: "functionality of CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell [Term] id: OBA:0003969 @@ -136806,8 +236157,8 @@ def: "The amount of a cochlear inner hair cell." [AUTO:patterns/patterns/entity_ synonym: "amount of cochlear inner hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003973 ! auditory hair cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000589 ! cochlear inner hair cell -relationship: inheres_in CL:0000589 ! cochlear inner hair cell +intersection_of: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell +relationship: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell [Term] id: OBA:0003970 @@ -136817,7 +236168,7 @@ synonym: "degeneration of cochlear inner hair cell" EXACT [AUTO:patterns/pattern is_a: OBA:0003961 ! auditory hair cell degeneration is_a: OBA:VT0004393 ! cochlear inner hair cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000589 ! cochlear inner hair cell +intersection_of: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell [Term] id: OBA:0003971 @@ -136826,8 +236177,8 @@ def: "The amount of a cochlear outer hair cell." [AUTO:patterns/patterns/entity_ synonym: "amount of cochlear outer hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003973 ! auditory hair cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell -relationship: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell +relationship: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:0003972 @@ -136837,7 +236188,7 @@ synonym: "degeneration of cochlear outer hair cell" EXACT [AUTO:patterns/pattern is_a: OBA:0003961 ! auditory hair cell degeneration is_a: OBA:VT0004399 ! cochlear outer hair cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:0003973 @@ -136846,8 +236197,8 @@ def: "The amount of a auditory hair cell." [AUTO:patterns/patterns/entity_attrib synonym: "amount of auditory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003577 ! sensory neuron amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000202 ! auditory hair cell -relationship: inheres_in CL:0000202 ! auditory hair cell +intersection_of: RO:0000052 CL:0000202 ! inheres in auditory hair cell +relationship: RO:0000052 CL:0000202 ! inheres in auditory hair cell [Term] id: OBA:0003974 @@ -136857,8 +236208,8 @@ synonym: "electric potential of cochlea" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001464 ! electric potential intersection_of: PATO:0001464 ! electric potential -intersection_of: inheres_in UBERON:0001844 ! cochlea -relationship: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea +relationship: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:0003975 @@ -136868,7 +236219,7 @@ synonym: "size of tetrapod parietal bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000109 ! parietal bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000210 ! tetrapod parietal bone +intersection_of: RO:0000052 UBERON:0000210 ! inheres in tetrapod parietal bone [Term] id: OBA:0003976 @@ -136878,7 +236229,7 @@ synonym: "size of temporal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0005272 ! temporal bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001678 ! temporal bone +intersection_of: RO:0000052 UBERON:0001678 ! inheres in temporal bone [Term] id: OBA:0003977 @@ -136888,8 +236239,8 @@ synonym: "amount of Meckel's cartilage" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003107 ! Meckel's cartilage -relationship: inheres_in UBERON:0003107 ! Meckel's cartilage +intersection_of: RO:0000052 UBERON:0003107 ! inheres in Meckel's cartilage +relationship: RO:0000052 UBERON:0003107 ! inheres in Meckel's cartilage [Term] id: OBA:0003978 @@ -136899,7 +236250,7 @@ synonym: "size of occipital bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000138 ! bone element size is_a: OBA:VT0005269 ! occipital bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:0003979 @@ -136909,7 +236260,7 @@ synonym: "structure of occipital bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0005269 ! occipital bone morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:0003980 @@ -136919,7 +236270,7 @@ synonym: "size of supraoccipital bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000078 ! supraoccipital bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004747 ! supraoccipital bone +intersection_of: RO:0000052 UBERON:0004747 ! inheres in supraoccipital bone [Term] id: OBA:0003981 @@ -136929,7 +236280,7 @@ synonym: "size of exoccipital bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000080 ! exoccipital bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001693 ! exoccipital bone +intersection_of: RO:0000052 UBERON:0001693 ! inheres in exoccipital bone [Term] id: OBA:0003982 @@ -136939,7 +236290,7 @@ synonym: "shape of exoccipital bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000080 ! exoccipital bone morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001693 ! exoccipital bone +intersection_of: RO:0000052 UBERON:0001693 ! inheres in exoccipital bone [Term] id: OBA:0003983 @@ -136949,7 +236300,7 @@ synonym: "size of basioccipital bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000079 ! basilar bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001692 ! basioccipital bone +intersection_of: RO:0000052 UBERON:0001692 ! inheres in basioccipital bone [Term] id: OBA:0003984 @@ -136959,7 +236310,7 @@ synonym: "size of presphenoid bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000138 ! bone element size is_a: OBA:VT0004448 ! presphenoid bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008828 ! presphenoid bone +intersection_of: RO:0000052 UBERON:0008828 ! inheres in presphenoid bone [Term] id: OBA:0003985 @@ -136969,7 +236320,7 @@ synonym: "length of presphenoid bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003984 ! presphenoid bone size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008828 ! presphenoid bone +intersection_of: RO:0000052 UBERON:0008828 ! inheres in presphenoid bone [Term] id: OBA:0003986 @@ -136979,8 +236330,8 @@ synonym: "amount of sphenoid bone pterygoid process" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004649 ! sphenoid bone pterygoid process -relationship: inheres_in UBERON:0004649 ! sphenoid bone pterygoid process +intersection_of: RO:0000052 UBERON:0004649 ! inheres in sphenoid bone pterygoid process +relationship: RO:0000052 UBERON:0004649 ! inheres in sphenoid bone pterygoid process [Term] id: OBA:0003987 @@ -136990,7 +236341,7 @@ synonym: "size of pterygoid bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004895 ! palate bone size is_a: OBA:VT0004453 ! pterygoid bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010389 ! pterygoid bone +intersection_of: RO:0000052 UBERON:0010389 ! inheres in pterygoid bone [Term] id: OBA:0003988 @@ -137000,8 +236351,8 @@ synonym: "amount of alisphenoid bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006721 ! alisphenoid bone -relationship: inheres_in UBERON:0006721 ! alisphenoid bone +intersection_of: RO:0000052 UBERON:0006721 ! inheres in alisphenoid bone +relationship: RO:0000052 UBERON:0006721 ! inheres in alisphenoid bone [Term] id: OBA:0003989 @@ -137011,7 +236362,7 @@ synonym: "size of alisphenoid bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000138 ! bone element size is_a: OBA:VT0003235 ! alisphenoid morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006721 ! alisphenoid bone +intersection_of: RO:0000052 UBERON:0006721 ! inheres in alisphenoid bone [Term] id: OBA:0003990 @@ -137021,7 +236372,7 @@ synonym: "size of basisphenoid bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000106 ! basisphenoid morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006428 ! basisphenoid bone +intersection_of: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone [Term] id: OBA:0003991 @@ -137031,7 +236382,7 @@ synonym: "structure of basisphenoid bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000106 ! basisphenoid morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0006428 ! basisphenoid bone +intersection_of: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone [Term] id: OBA:0003992 @@ -137041,7 +236392,7 @@ synonym: "degeneration of organ of Corti supporting cell" EXACT [AUTO:patterns/p is_a: OBA:VT0004300 ! organ of Corti supporting cell morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002490 ! organ of Corti supporting cell +intersection_of: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell [Term] id: OBA:0003993 @@ -137051,7 +236402,7 @@ synonym: "size of palatine bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004895 ! palate bone size is_a: OBA:VT0005249 ! palatine bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001682 ! palatine bone +intersection_of: RO:0000052 UBERON:0001682 ! inheres in palatine bone [Term] id: OBA:0003994 @@ -137061,7 +236412,7 @@ synonym: "size of turbinate bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000138 ! bone element size is_a: OBA:VT0002244 ! turbinated bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001762 ! turbinate bone +intersection_of: RO:0000052 UBERON:0001762 ! inheres in turbinate bone [Term] id: OBA:0003995 @@ -137071,8 +236422,8 @@ synonym: "deviation (from_normal) of epithelium of conjunctiva" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0006763 ! epithelium of conjunctiva -relationship: inheres_in UBERON:0006763 ! epithelium of conjunctiva +intersection_of: RO:0000052 UBERON:0006763 ! inheres in epithelium of conjunctiva +relationship: RO:0000052 UBERON:0006763 ! inheres in epithelium of conjunctiva [Term] id: OBA:0003996 @@ -137082,8 +236433,8 @@ synonym: "amount of interdental cell of cochlea" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002172 ! interdental cell of cochlea -relationship: inheres_in CL:0002172 ! interdental cell of cochlea +intersection_of: RO:0000052 CL:0002172 ! inheres in interdental cell of cochlea +relationship: RO:0000052 CL:0002172 ! inheres in interdental cell of cochlea [Term] id: OBA:0003997 @@ -137093,7 +236444,7 @@ synonym: "degeneration of type 1 otic fibrocyte" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0004293 ! type I spiral ligament fibrocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002670 ! type 1 otic fibrocyte +intersection_of: RO:0000052 CL:0002670 ! inheres in type 1 otic fibrocyte [Term] id: OBA:0003998 @@ -137103,7 +236454,7 @@ synonym: "degeneration of type 2 otic fibrocyte" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0004294 ! type II spiral ligament fibrocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002666 ! type 2 otic fibrocyte +intersection_of: RO:0000052 CL:0002666 ! inheres in type 2 otic fibrocyte [Term] id: OBA:0003999 @@ -137113,7 +236464,7 @@ synonym: "degeneration of type 3 otic fibrocyte" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0004295 ! type III spiral ligament fibrocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002669 ! type 3 otic fibrocyte +intersection_of: RO:0000052 CL:0002669 ! inheres in type 3 otic fibrocyte [Term] id: OBA:0004000 @@ -137123,7 +236474,7 @@ synonym: "degeneration of type 4 otic fibrocyte" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0004296 ! type IV spiral ligament fibrocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0002668 ! type 4 otic fibrocyte +intersection_of: RO:0000052 CL:0002668 ! inheres in type 4 otic fibrocyte [Term] id: OBA:0004001 @@ -137133,8 +236484,8 @@ synonym: "rate of glutamate secretion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0014047 ! glutamate secretion -relationship: inheres_in GO:0014047 ! glutamate secretion +intersection_of: RO:0000052 GO:0014047 ! inheres in glutamate secretion +relationship: RO:0000052 GO:0014047 ! inheres in glutamate secretion [Term] id: OBA:0004002 @@ -137143,8 +236494,8 @@ def: "The morphology of a shoulder bone." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of shoulder bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003695 ! bone of appendage girdle complex morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003461 ! shoulder bone -relationship: inheres_in UBERON:0003461 ! shoulder bone +intersection_of: RO:0000052 UBERON:0003461 ! inheres in shoulder bone +relationship: RO:0000052 UBERON:0003461 ! inheres in shoulder bone [Term] id: OBA:0004003 @@ -137154,7 +236505,7 @@ synonym: "duration of parturition" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002907 ! parturition trait is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in GO:0007567 ! parturition +intersection_of: RO:0000052 GO:0007567 ! inheres in parturition [Term] id: OBA:0004004 @@ -137164,8 +236515,8 @@ synonym: "morphology of palatine bone horizontal plate" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0018242 ! palatine bone horizontal plate -relationship: inheres_in UBERON:0018242 ! palatine bone horizontal plate +intersection_of: RO:0000052 UBERON:0018242 ! inheres in palatine bone horizontal plate +relationship: RO:0000052 UBERON:0018242 ! inheres in palatine bone horizontal plate [Term] id: OBA:0004005 @@ -137175,8 +236526,8 @@ synonym: "deviation (from_normal) of palatine process of maxilla" EXACT [AUTO:pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0005871 ! palatine process of maxilla -relationship: inheres_in UBERON:0005871 ! palatine process of maxilla +intersection_of: RO:0000052 UBERON:0005871 ! inheres in palatine process of maxilla +relationship: RO:0000052 UBERON:0005871 ! inheres in palatine process of maxilla [Term] id: OBA:0004006 @@ -137186,8 +236537,8 @@ synonym: "rate of acrosome reaction" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007340 ! acrosome reaction -relationship: inheres_in GO:0007340 ! acrosome reaction +intersection_of: RO:0000052 GO:0007340 ! inheres in acrosome reaction +relationship: RO:0000052 GO:0007340 ! inheres in acrosome reaction [Term] id: OBA:0004007 @@ -137197,8 +236548,8 @@ synonym: "functionality of sperm" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003194 ! cell functionality is_a: OBA:1000722 ! gamete quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000019 ! sperm -relationship: inheres_in CL:0000019 ! sperm +intersection_of: RO:0000052 CL:0000019 ! inheres in sperm +relationship: RO:0000052 CL:0000019 ! inheres in sperm [Term] id: OBA:0004008 @@ -137208,7 +236559,7 @@ synonym: "length of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000167 ! tracheal tube length is_a: OBA:0003181 ! trachea size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0004009 @@ -137218,8 +236569,8 @@ synonym: "amount of trachea cartilage" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003604 ! trachea cartilage -relationship: inheres_in UBERON:0003604 ! trachea cartilage +intersection_of: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage +relationship: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage [Term] id: OBA:0004010 @@ -137229,7 +236580,7 @@ synonym: "size of allantois" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001726 ! allantois morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004340 ! allantois +intersection_of: RO:0000052 UBERON:0004340 ! inheres in allantois [Term] id: OBA:0004011 @@ -137239,7 +236590,7 @@ synonym: "structure of allantois" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001726 ! allantois morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004340 ! allantois +intersection_of: RO:0000052 UBERON:0004340 ! inheres in allantois [Term] id: OBA:0004012 @@ -137249,8 +236600,8 @@ synonym: "morphology of chorionic plate" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004027 ! chorionic plate -relationship: inheres_in UBERON:0004027 ! chorionic plate +intersection_of: RO:0000052 UBERON:0004027 ! inheres in chorionic plate +relationship: RO:0000052 UBERON:0004027 ! inheres in chorionic plate [Term] id: OBA:0004013 @@ -137260,7 +236611,7 @@ synonym: "size of cardiac muscle cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000055 ! cell size is_a: OBA:VT0000061 ! cardiomyocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:0004014 @@ -137270,7 +236621,7 @@ synonym: "degeneration of cardiac muscle cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0000061 ! cardiomyocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:0004015 @@ -137280,8 +236631,8 @@ synonym: "amount of cardiac muscle cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell -relationship: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell +relationship: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:0004016 @@ -137291,7 +236642,7 @@ synonym: "size of glossopharyngeal nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001073 ! glossopharyngeal nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001649 ! glossopharyngeal nerve +intersection_of: RO:0000052 UBERON:0001649 ! inheres in glossopharyngeal nerve [Term] id: OBA:0004017 @@ -137301,8 +236652,8 @@ synonym: "amount of limb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004347 ! limb bud -relationship: inheres_in UBERON:0004347 ! limb bud +intersection_of: RO:0000052 UBERON:0004347 ! inheres in limb bud +relationship: RO:0000052 UBERON:0004347 ! inheres in limb bud [Term] id: OBA:0004018 @@ -137312,7 +236663,7 @@ synonym: "size of limb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005650 ! limb bud morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004347 ! limb bud +intersection_of: RO:0000052 UBERON:0004347 ! inheres in limb bud [Term] id: OBA:0004019 @@ -137322,8 +236673,8 @@ synonym: "morphology of embryonic footplate" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006871 ! embryonic footplate -relationship: inheres_in UBERON:0006871 ! embryonic footplate +intersection_of: RO:0000052 UBERON:0006871 ! inheres in embryonic footplate +relationship: RO:0000052 UBERON:0006871 ! inheres in embryonic footplate [Term] id: OBA:0004020 @@ -137333,7 +236684,7 @@ synonym: "degeneration of pillar cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003992 ! organ of Corti supporting cell degeneration is_a: OBA:VT0003825 ! pillar cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:1000191 ! pillar cell +intersection_of: RO:0000052 CL:1000191 ! inheres in pillar cell [Term] id: OBA:0004021 @@ -137343,7 +236694,7 @@ synonym: "morphology of mandible coronoid process" EXACT [AUTO:patterns/patterns is_a: OBA:1000371 ! mandible coronoid process quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004660 ! mandible coronoid process +intersection_of: RO:0000052 UBERON:0004660 ! inheres in mandible coronoid process [Term] id: OBA:0004022 @@ -137353,7 +236704,7 @@ synonym: "morphology of mandible condylar process" EXACT [AUTO:patterns/patterns is_a: OBA:1000352 ! mandible condylar process quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004657 ! mandible condylar process +intersection_of: RO:0000052 UBERON:0004657 ! inheres in mandible condylar process [Term] id: OBA:0004023 @@ -137363,8 +236714,8 @@ synonym: "morphology of mandible angular process" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006959 ! mandible angular process -relationship: inheres_in UBERON:0006959 ! mandible angular process +intersection_of: RO:0000052 UBERON:0006959 ! inheres in mandible angular process +relationship: RO:0000052 UBERON:0006959 ! inheres in mandible angular process [Term] id: OBA:0004024 @@ -137373,8 +236724,8 @@ def: "The morphology of a neural arch." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of neural arch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003861 ! neural arch -relationship: inheres_in UBERON:0003861 ! neural arch +intersection_of: RO:0000052 UBERON:0003861 ! inheres in neural arch +relationship: RO:0000052 UBERON:0003861 ! inheres in neural arch [Term] id: OBA:0004025 @@ -137384,8 +236735,8 @@ synonym: "morphology of vertebra lamina" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004662 ! vertebra lamina -relationship: inheres_in UBERON:0004662 ! vertebra lamina +intersection_of: RO:0000052 UBERON:0004662 ! inheres in vertebra lamina +relationship: RO:0000052 UBERON:0004662 ! inheres in vertebra lamina [Term] id: OBA:0004026 @@ -137394,8 +236745,8 @@ def: "The morphology of a vertebral bone 1." [AUTO:patterns/patterns/entity_attr synonym: "morphology of vertebral bone 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001092 ! vertebral bone 1 -relationship: inheres_in UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0000052 UBERON:0001092 ! inheres in vertebral bone 1 +relationship: RO:0000052 UBERON:0001092 ! inheres in vertebral bone 1 [Term] id: OBA:0004027 @@ -137404,8 +236755,8 @@ def: "The morphology of a vertebral bone 2." [AUTO:patterns/patterns/entity_attr synonym: "morphology of vertebral bone 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001093 ! vertebral bone 2 -relationship: inheres_in UBERON:0001093 ! vertebral bone 2 +intersection_of: RO:0000052 UBERON:0001093 ! inheres in vertebral bone 2 +relationship: RO:0000052 UBERON:0001093 ! inheres in vertebral bone 2 [Term] id: OBA:0004028 @@ -137415,7 +236766,7 @@ synonym: "structure of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0004029 @@ -137425,8 +236776,8 @@ synonym: "morphology of trochanter" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000980 ! trochanter -relationship: inheres_in UBERON:0000980 ! trochanter +intersection_of: RO:0000052 UBERON:0000980 ! inheres in trochanter +relationship: RO:0000052 UBERON:0000980 ! inheres in trochanter [Term] id: OBA:0004030 @@ -137436,7 +236787,7 @@ synonym: "degeneration of Deiter's cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003992 ! organ of Corti supporting cell degeneration is_a: OBA:VT0004302 ! Deiters cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000635 ! Deiter's cell +intersection_of: RO:0000052 CL:0000635 ! inheres in Deiter's cell [Term] id: OBA:0004031 @@ -137446,8 +236797,8 @@ synonym: "morphology of spiral modiolar artery" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002505 ! spiral modiolar artery -relationship: inheres_in UBERON:0002505 ! spiral modiolar artery +intersection_of: RO:0000052 UBERON:0002505 ! inheres in spiral modiolar artery +relationship: RO:0000052 UBERON:0002505 ! inheres in spiral modiolar artery [Term] id: OBA:0004032 @@ -137457,7 +236808,7 @@ synonym: "structure of spiral modiolar artery" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003389 ! artery structure is_a: OBA:0004031 ! spiral modiolar artery morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002505 ! spiral modiolar artery +intersection_of: RO:0000052 UBERON:0002505 ! inheres in spiral modiolar artery [Term] id: OBA:0004033 @@ -137467,7 +236818,7 @@ synonym: "length of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002251 ! metatarsal bone size is_a: OBA:0002381 ! long bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001448 ! metatarsal bone +intersection_of: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone [Term] id: OBA:0004034 @@ -137477,8 +236828,8 @@ synonym: "amount of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001448 ! metatarsal bone -relationship: inheres_in UBERON:0001448 ! metatarsal bone +intersection_of: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone +relationship: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone [Term] id: OBA:0004035 @@ -137487,8 +236838,8 @@ def: "The amount of a cervical vertebra." [AUTO:patterns/patterns/entity_attribu synonym: "amount of cervical vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003506 ! trunk or cervical vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra -relationship: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra +relationship: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0004036 @@ -137497,8 +236848,8 @@ def: "The amount of a lumbar vertebra." [AUTO:patterns/patterns/entity_attribute synonym: "amount of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002371 ! vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra -relationship: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra +relationship: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:0004037 @@ -137507,8 +236858,8 @@ def: "The amount of a thoracic vertebra." [AUTO:patterns/patterns/entity_attribu synonym: "amount of thoracic vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002371 ! vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002347 ! thoracic vertebra -relationship: inheres_in UBERON:0002347 ! thoracic vertebra +intersection_of: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra +relationship: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra [Term] id: OBA:0004038 @@ -137517,8 +236868,8 @@ def: "The amount of a sacral vertebra." [AUTO:patterns/patterns/entity_attribute synonym: "amount of sacral vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002371 ! vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001094 ! sacral vertebra -relationship: inheres_in UBERON:0001094 ! sacral vertebra +intersection_of: RO:0000052 UBERON:0001094 ! inheres in sacral vertebra +relationship: RO:0000052 UBERON:0001094 ! inheres in sacral vertebra [Term] id: OBA:0004039 @@ -137528,7 +236879,7 @@ synonym: "onset quality of inner ear development" EXACT [AUTO:patterns/patterns/ is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0015111 ! inner ear development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0048839 ! inner ear development +intersection_of: RO:0000052 GO:0048839 ! inheres in inner ear development [Term] id: OBA:0004040 @@ -137538,8 +236889,8 @@ synonym: "morphology of stapedial artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006345 ! stapedial artery -relationship: inheres_in UBERON:0006345 ! stapedial artery +intersection_of: RO:0000052 UBERON:0006345 ! inheres in stapedial artery +relationship: RO:0000052 UBERON:0006345 ! inheres in stapedial artery [Term] id: OBA:0004041 @@ -137550,7 +236901,7 @@ is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0000150 ! rib morphology trait is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:0004042 @@ -137562,7 +236913,7 @@ is_a: OBA:VT0000163 ! cartilage morphology trait is_a: OBA:VT0010093 ! costal cartilage morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006430 ! xiphoid cartilage +intersection_of: RO:0000052 UBERON:0006430 ! inheres in xiphoid cartilage [Term] id: OBA:0004043 @@ -137574,7 +236925,7 @@ is_a: OBA:VT0000163 ! cartilage morphology trait is_a: OBA:VT0010093 ! costal cartilage morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0006430 ! xiphoid cartilage +intersection_of: RO:0000052 UBERON:0006430 ! inheres in xiphoid cartilage [Term] id: OBA:0004044 @@ -137585,7 +236936,7 @@ is_a: OBA:0003727 ! cartilage tissue size is_a: OBA:1000653 ! xiphoid cartilage quality is_a: OBA:VT0010093 ! costal cartilage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006430 ! xiphoid cartilage +intersection_of: RO:0000052 UBERON:0006430 ! inheres in xiphoid cartilage [Term] id: OBA:0004045 @@ -137595,7 +236946,7 @@ synonym: "size of intervertebral disk" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004173 ! intervertebral disk morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:0004046 @@ -137605,8 +236956,8 @@ synonym: "morphology of thyroid follicle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005305 ! thyroid follicle -relationship: inheres_in UBERON:0005305 ! thyroid follicle +intersection_of: RO:0000052 UBERON:0005305 ! inheres in thyroid follicle +relationship: RO:0000052 UBERON:0005305 ! inheres in thyroid follicle [Term] id: OBA:0004048 @@ -137616,7 +236967,7 @@ synonym: "length of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0010518 ! lumbar vertebra size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:0004049 @@ -137626,7 +236977,7 @@ synonym: "degeneration of cervical vertebra" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002840 ! cervical vertebra structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0004050 @@ -137636,7 +236987,7 @@ synonym: "size of notochord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002825 ! notochord morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002328 ! notochord +intersection_of: RO:0000052 UBERON:0002328 ! inheres in notochord [Term] id: OBA:0004051 @@ -137646,7 +236997,7 @@ synonym: "degeneration of notochord" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0002825 ! notochord morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002328 ! notochord +intersection_of: RO:0000052 UBERON:0002328 ! inheres in notochord [Term] id: OBA:0004052 @@ -137656,7 +237007,7 @@ synonym: "shape of notochord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002825 ! notochord morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002328 ! notochord +intersection_of: RO:0000052 UBERON:0002328 ! inheres in notochord [Term] id: OBA:0004053 @@ -137666,7 +237017,7 @@ synonym: "morphology of cochlear nerve" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000431 ! cochlear nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004727 ! cochlear nerve +intersection_of: RO:0000052 UBERON:0004727 ! inheres in cochlear nerve [Term] id: OBA:0004054 @@ -137676,7 +237027,7 @@ synonym: "morphology of vestibular nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000198 ! vestibular nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003723 ! vestibular nerve +intersection_of: RO:0000052 UBERON:0003723 ! inheres in vestibular nerve [Term] id: OBA:0004055 @@ -137686,8 +237037,8 @@ synonym: "morphology of platelet dense granule" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0042827 ! platelet dense granule -relationship: inheres_in GO:0042827 ! platelet dense granule +intersection_of: RO:0000052 GO:0042827 ! inheres in platelet dense granule +relationship: RO:0000052 GO:0042827 ! inheres in platelet dense granule [Term] id: OBA:0004056 @@ -137697,8 +237048,8 @@ synonym: "amount of platelet dense granule" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042827 ! platelet dense granule -relationship: inheres_in GO:0042827 ! platelet dense granule +intersection_of: RO:0000052 GO:0042827 ! inheres in platelet dense granule +relationship: RO:0000052 GO:0042827 ! inheres in platelet dense granule [Term] id: OBA:0004057 @@ -137708,8 +237059,8 @@ synonym: "morphology of nasal capsule" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002355 ! cartilage element morphology is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006332 ! nasal capsule -relationship: inheres_in UBERON:0006332 ! nasal capsule +intersection_of: RO:0000052 UBERON:0006332 ! inheres in nasal capsule +relationship: RO:0000052 UBERON:0006332 ! inheres in nasal capsule [Term] id: OBA:0004058 @@ -137719,7 +237070,7 @@ synonym: "size of thoracic cavity" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0015045 ! thoracic cavity morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002224 ! thoracic cavity +intersection_of: RO:0000052 UBERON:0002224 ! inheres in thoracic cavity [Term] id: OBA:0004059 @@ -137729,8 +237080,8 @@ synonym: "morphology of synaptic vesicle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0008021 ! synaptic vesicle -relationship: inheres_in GO:0008021 ! synaptic vesicle +intersection_of: RO:0000052 GO:0008021 ! inheres in synaptic vesicle +relationship: RO:0000052 GO:0008021 ! inheres in synaptic vesicle [Term] id: OBA:0004060 @@ -137740,8 +237091,8 @@ synonym: "composition of bile" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001970 ! bile -relationship: inheres_in UBERON:0001970 ! bile +intersection_of: RO:0000052 UBERON:0001970 ! inheres in bile +relationship: RO:0000052 UBERON:0001970 ! inheres in bile [Term] id: OBA:0004061 @@ -137751,7 +237102,7 @@ synonym: "degeneration of vestibular dark cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0001457 ! vestibular dark cell morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000846 ! vestibular dark cell +intersection_of: RO:0000052 CL:0000846 ! inheres in vestibular dark cell [Term] id: OBA:0004062 @@ -137760,8 +237111,8 @@ def: "The amount of a macrophage derived foam cell." [AUTO:patterns/patterns/ent synonym: "amount of macrophage derived foam cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002444 ! foam cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000517 ! macrophage derived foam cell -relationship: inheres_in CL:0000517 ! macrophage derived foam cell +intersection_of: RO:0000052 CL:0000517 ! inheres in macrophage derived foam cell +relationship: RO:0000052 CL:0000517 ! inheres in macrophage derived foam cell [Term] id: OBA:0004063 @@ -137771,8 +237122,8 @@ synonym: "composition of pulmonary surfactant" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0008826 ! pulmonary surfactant -relationship: inheres_in UBERON:0008826 ! pulmonary surfactant +intersection_of: RO:0000052 UBERON:0008826 ! inheres in pulmonary surfactant +relationship: RO:0000052 UBERON:0008826 ! inheres in pulmonary surfactant [Term] id: OBA:0004064 @@ -137781,8 +237132,8 @@ def: "The morphology of a cardinal vein." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of cardinal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004344 ! cardinal vein -relationship: inheres_in UBERON:0004344 ! cardinal vein +intersection_of: RO:0000052 UBERON:0004344 ! inheres in cardinal vein +relationship: RO:0000052 UBERON:0004344 ! inheres in cardinal vein [Term] id: OBA:0004065 @@ -137791,8 +237142,8 @@ def: "The morphology of a anterior cardinal vein." [AUTO:patterns/patterns/entit synonym: "morphology of anterior cardinal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004064 ! cardinal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003087 ! anterior cardinal vein -relationship: inheres_in UBERON:0003087 ! anterior cardinal vein +intersection_of: RO:0000052 UBERON:0003087 ! inheres in anterior cardinal vein +relationship: RO:0000052 UBERON:0003087 ! inheres in anterior cardinal vein [Term] id: OBA:0004066 @@ -137801,8 +237152,8 @@ def: "The morphology of a posterior cardinal vein." [AUTO:patterns/patterns/enti synonym: "morphology of posterior cardinal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004064 ! cardinal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002065 ! posterior cardinal vein -relationship: inheres_in UBERON:0002065 ! posterior cardinal vein +intersection_of: RO:0000052 UBERON:0002065 ! inheres in posterior cardinal vein +relationship: RO:0000052 UBERON:0002065 ! inheres in posterior cardinal vein [Term] id: OBA:0004067 @@ -137811,8 +237162,8 @@ def: "The morphology of a common cardinal vein." [AUTO:patterns/patterns/entity_ synonym: "morphology of common cardinal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004064 ! cardinal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002064 ! common cardinal vein -relationship: inheres_in UBERON:0002064 ! common cardinal vein +intersection_of: RO:0000052 UBERON:0002064 ! inheres in common cardinal vein +relationship: RO:0000052 UBERON:0002064 ! inheres in common cardinal vein [Term] id: OBA:0004068 @@ -137822,8 +237173,8 @@ synonym: "morphology of pair of dorsal aortae" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010190 ! pair of dorsal aortae -relationship: inheres_in UBERON:0010190 ! pair of dorsal aortae +intersection_of: RO:0000052 UBERON:0010190 ! inheres in pair of dorsal aortae +relationship: RO:0000052 UBERON:0010190 ! inheres in pair of dorsal aortae [Term] id: OBA:0004069 @@ -137833,8 +237184,8 @@ synonym: "amount of synaptic vesicle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0008021 ! synaptic vesicle -relationship: inheres_in GO:0008021 ! synaptic vesicle +intersection_of: RO:0000052 GO:0008021 ! inheres in synaptic vesicle +relationship: RO:0000052 GO:0008021 ! inheres in synaptic vesicle [Term] id: OBA:0004070 @@ -137843,8 +237194,8 @@ def: "The morphology of a hematopoietic stem cell." [AUTO:patterns/patterns/enti synonym: "morphology of hematopoietic stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000037 ! hematopoietic stem cell -relationship: inheres_in CL:0000037 ! hematopoietic stem cell +intersection_of: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell +relationship: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell [Term] id: OBA:0004071 @@ -137853,8 +237204,8 @@ def: "The amount of a hematopoietic stem cell." [AUTO:patterns/patterns/entity_a synonym: "amount of hematopoietic stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000037 ! hematopoietic stem cell -relationship: inheres_in CL:0000037 ! hematopoietic stem cell +intersection_of: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell +relationship: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell [Term] id: OBA:0004072 @@ -137863,8 +237214,8 @@ def: "The functionality of a neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "functionality of neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000540 ! neuron -relationship: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron +relationship: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:0004073 @@ -137874,8 +237225,8 @@ synonym: "frequency of somatic hypermutation of immunoglobulin genes" EXACT [AUT is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0016446 ! somatic hypermutation of immunoglobulin genes -relationship: inheres_in GO:0016446 ! somatic hypermutation of immunoglobulin genes +intersection_of: RO:0000052 GO:0016446 ! inheres in somatic hypermutation of immunoglobulin genes +relationship: RO:0000052 GO:0016446 ! inheres in somatic hypermutation of immunoglobulin genes [Term] id: OBA:0004074 @@ -137890,7 +237241,7 @@ synonym: "length of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000113 ! incisor size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0004076 @@ -137899,8 +237250,8 @@ def: "The morphology of a crypt of Lieberkuhn of small intestine." [AUTO:pattern synonym: "morphology of crypt of Lieberkuhn of small intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000490 ! crypt of Lieberkuhn morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001241 ! crypt of Lieberkuhn of small intestine -relationship: inheres_in UBERON:0001241 ! crypt of Lieberkuhn of small intestine +intersection_of: RO:0000052 UBERON:0001241 ! inheres in crypt of Lieberkuhn of small intestine +relationship: RO:0000052 UBERON:0001241 ! inheres in crypt of Lieberkuhn of small intestine [Term] id: OBA:0004077 @@ -137909,8 +237260,8 @@ def: "The morphology of a crypt of Lieberkuhn of large intestine." [AUTO:pattern synonym: "morphology of crypt of Lieberkuhn of large intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000490 ! crypt of Lieberkuhn morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001984 ! crypt of Lieberkuhn of large intestine -relationship: inheres_in UBERON:0001984 ! crypt of Lieberkuhn of large intestine +intersection_of: RO:0000052 UBERON:0001984 ! inheres in crypt of Lieberkuhn of large intestine +relationship: RO:0000052 UBERON:0001984 ! inheres in crypt of Lieberkuhn of large intestine [Term] id: OBA:0004078 @@ -137919,8 +237270,8 @@ def: "The morphology of a paneth cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of paneth cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000510 ! paneth cell -relationship: inheres_in CL:0000510 ! paneth cell +intersection_of: RO:0000052 CL:0000510 ! inheres in paneth cell +relationship: RO:0000052 CL:0000510 ! inheres in paneth cell [Term] id: OBA:0004079 @@ -137935,7 +237286,7 @@ synonym: "size of collecting duct of renal tubule" EXACT [AUTO:patterns/patterns is_a: OBA:0000172 ! tube size is_a: OBA:VT0010068 ! kidney collecting duct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001232 ! collecting duct of renal tubule +intersection_of: RO:0000052 UBERON:0001232 ! inheres in collecting duct of renal tubule [Term] id: OBA:0004081 @@ -137945,7 +237296,7 @@ synonym: "degeneration of spiral ligament" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0004288 ! spiral ligament morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0006725 ! spiral ligament +intersection_of: RO:0000052 UBERON:0006725 ! inheres in spiral ligament [Term] id: OBA:0004082 @@ -137955,8 +237306,8 @@ synonym: "amount of nasal septum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001706 ! nasal septum -relationship: inheres_in UBERON:0001706 ! nasal septum +intersection_of: RO:0000052 UBERON:0001706 ! inheres in nasal septum +relationship: RO:0000052 UBERON:0001706 ! inheres in nasal septum [Term] id: OBA:0004083 @@ -137966,7 +237317,7 @@ synonym: "morphology of endometrium" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000546 ! endometrium quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001295 ! endometrium +intersection_of: RO:0000052 UBERON:0001295 ! inheres in endometrium [Term] id: OBA:0004084 @@ -137976,7 +237327,7 @@ synonym: "amount of zygomatic arch" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000511 ! zygomatic arch quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002500 ! zygomatic arch +intersection_of: RO:0000052 UBERON:0002500 ! inheres in zygomatic arch [Term] id: OBA:0004085 @@ -137986,7 +237337,7 @@ synonym: "size of male germ cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000055 ! cell size is_a: OBA:0003333 ! male germ cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000015 ! male germ cell +intersection_of: RO:0000052 CL:0000015 ! inheres in male germ cell [Term] id: OBA:0004086 @@ -138006,7 +237357,7 @@ synonym: "amount of mandible condylar process" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000352 ! mandible condylar process quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004657 ! mandible condylar process +intersection_of: RO:0000052 UBERON:0004657 ! inheres in mandible condylar process [Term] id: OBA:0004089 @@ -138016,7 +237367,7 @@ synonym: "amount of mandible coronoid process" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000371 ! mandible coronoid process quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004660 ! mandible coronoid process +intersection_of: RO:0000052 UBERON:0004660 ! inheres in mandible coronoid process [Term] id: OBA:0004090 @@ -138026,8 +237377,8 @@ synonym: "amount of mandible angular process" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006959 ! mandible angular process -relationship: inheres_in UBERON:0006959 ! mandible angular process +intersection_of: RO:0000052 UBERON:0006959 ! inheres in mandible angular process +relationship: RO:0000052 UBERON:0006959 ! inheres in mandible angular process [Term] id: OBA:0004091 @@ -138037,8 +237388,8 @@ synonym: "amount of ultimobranchial body" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003092 ! ultimobranchial body -relationship: inheres_in UBERON:0003092 ! ultimobranchial body +intersection_of: RO:0000052 UBERON:0003092 ! inheres in ultimobranchial body +relationship: RO:0000052 UBERON:0003092 ! inheres in ultimobranchial body [Term] id: OBA:0004092 @@ -138048,8 +237399,8 @@ synonym: "amount of Reichert's cartilage" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004368 ! Reichert's cartilage -relationship: inheres_in UBERON:0004368 ! Reichert's cartilage +intersection_of: RO:0000052 UBERON:0004368 ! inheres in Reichert's cartilage +relationship: RO:0000052 UBERON:0004368 ! inheres in Reichert's cartilage [Term] id: OBA:0004093 @@ -138059,8 +237410,8 @@ synonym: "morphology of crus commune" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005600 ! crus commune -relationship: inheres_in UBERON:0005600 ! crus commune +intersection_of: RO:0000052 UBERON:0005600 ! inheres in crus commune +relationship: RO:0000052 UBERON:0005600 ! inheres in crus commune [Term] id: OBA:0004094 @@ -138070,7 +237421,7 @@ synonym: "size of epididymis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0002631 ! epididymis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001301 ! epididymis +intersection_of: RO:0000052 UBERON:0001301 ! inheres in epididymis [Term] id: OBA:0004095 @@ -138085,8 +237436,8 @@ synonym: "morphology of epididymis epithelium" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004544 ! epididymis epithelium -relationship: inheres_in UBERON:0004544 ! epididymis epithelium +intersection_of: RO:0000052 UBERON:0004544 ! inheres in epididymis epithelium +relationship: RO:0000052 UBERON:0004544 ! inheres in epididymis epithelium [Term] id: OBA:0004097 @@ -138096,7 +237447,7 @@ synonym: "degeneration of epididymis epithelium" EXACT [AUTO:patterns/patterns/e is_a: OBA:0004096 ! epididymis epithelium morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0004544 ! epididymis epithelium +intersection_of: RO:0000052 UBERON:0004544 ! inheres in epididymis epithelium [Term] id: OBA:0004098 @@ -138106,7 +237457,7 @@ synonym: "degeneration of epididymis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0002631 ! epididymis morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001301 ! epididymis +intersection_of: RO:0000052 UBERON:0001301 ! inheres in epididymis [Term] id: OBA:0004099 @@ -138116,7 +237467,7 @@ synonym: "functionality of branching involved in ureteric bud morphogenesis" EXA is_a: OBA:1000669 ! branching involved in ureteric bud morphogenesis quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0001658 ! branching involved in ureteric bud morphogenesis +intersection_of: RO:0000052 GO:0001658 ! inheres in branching involved in ureteric bud morphogenesis [Term] id: OBA:0004100 @@ -138126,8 +237477,8 @@ synonym: "morphology of blastocyst development" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0001824 ! blastocyst development -relationship: inheres_in GO:0001824 ! blastocyst development +intersection_of: RO:0000052 GO:0001824 ! inheres in blastocyst development +relationship: RO:0000052 GO:0001824 ! inheres in blastocyst development [Term] id: OBA:0004101 @@ -138142,8 +237493,8 @@ synonym: "morphology of blastocele" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000090 ! blastocele -relationship: inheres_in UBERON:0000090 ! blastocele +intersection_of: RO:0000052 UBERON:0000090 ! inheres in blastocele +relationship: RO:0000052 UBERON:0000090 ! inheres in blastocele [Term] id: OBA:0004103 @@ -138153,8 +237504,8 @@ synonym: "amount of inner cell mass" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000087 ! inner cell mass -relationship: inheres_in UBERON:0000087 ! inner cell mass +intersection_of: RO:0000052 UBERON:0000087 ! inheres in inner cell mass +relationship: RO:0000052 UBERON:0000087 ! inheres in inner cell mass [Term] id: OBA:0004104 @@ -138164,7 +237515,7 @@ synonym: "degeneration of inner cell mass" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002718 ! inner cell mass morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000087 ! inner cell mass +intersection_of: RO:0000052 UBERON:0000087 ! inheres in inner cell mass [Term] id: OBA:0004105 @@ -138174,8 +237525,8 @@ synonym: "morphology of kidney epithelium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004819 ! kidney epithelium -relationship: inheres_in UBERON:0004819 ! kidney epithelium +intersection_of: RO:0000052 UBERON:0004819 ! inheres in kidney epithelium +relationship: RO:0000052 UBERON:0004819 ! inheres in kidney epithelium [Term] id: OBA:0004106 @@ -138185,7 +237536,7 @@ synonym: "size of kidney epithelium" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004819 ! kidney epithelium +intersection_of: RO:0000052 UBERON:0004819 ! inheres in kidney epithelium [Term] id: OBA:0004107 @@ -138195,8 +237546,8 @@ synonym: "color saturation of kidney" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0004108 @@ -138205,8 +237556,8 @@ def: "The amount of a regulatory T cell." [AUTO:patterns/patterns/entity_attribu synonym: "amount of regulatory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000815 ! regulatory T cell -relationship: inheres_in CL:0000815 ! regulatory T cell +intersection_of: RO:0000052 CL:0000815 ! inheres in regulatory T cell +relationship: RO:0000052 CL:0000815 ! inheres in regulatory T cell [Term] id: OBA:0004109 @@ -138215,8 +237566,8 @@ def: "The amount of a B-1 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of B-1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000819 ! B-1 B cell -relationship: inheres_in CL:0000819 ! B-1 B cell +intersection_of: RO:0000052 CL:0000819 ! inheres in B-1 B cell +relationship: RO:0000052 CL:0000819 ! inheres in B-1 B cell [Term] id: OBA:0004110 @@ -138226,8 +237577,8 @@ synonym: "amount of neuroblast (sensu Vertebrata)" EXACT [AUTO:patterns/patterns is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000031 ! neuroblast (sensu Vertebrata) -relationship: inheres_in CL:0000031 ! neuroblast (sensu Vertebrata) +intersection_of: RO:0000052 CL:0000031 ! inheres in neuroblast (sensu Vertebrata) +relationship: RO:0000052 CL:0000031 ! inheres in neuroblast (sensu Vertebrata) [Term] id: OBA:0004111 @@ -138238,8 +237589,8 @@ is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000092 ! osteoclast -relationship: inheres_in CL:0000092 ! osteoclast +intersection_of: RO:0000052 CL:0000092 ! inheres in osteoclast +relationship: RO:0000052 CL:0000092 ! inheres in osteoclast [Term] id: OBA:0004112 @@ -138249,8 +237600,8 @@ synonym: "amount of osteoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000062 ! osteoblast -relationship: inheres_in CL:0000062 ! osteoblast +intersection_of: RO:0000052 CL:0000062 ! inheres in osteoblast +relationship: RO:0000052 CL:0000062 ! inheres in osteoblast [Term] id: OBA:0004113 @@ -138261,7 +237612,7 @@ is_a: OBA:1000451 ! main ciliary ganglion quality is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002058 ! main ciliary ganglion +intersection_of: RO:0000052 UBERON:0002058 ! inheres in main ciliary ganglion [Term] id: OBA:0004114 @@ -138271,7 +237622,7 @@ synonym: "rate of bone resorption" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000900 ! bone resorption quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0045453 ! bone resorption +intersection_of: RO:0000052 GO:0045453 ! inheres in bone resorption [Term] id: OBA:0004115 @@ -138281,8 +237632,8 @@ synonym: "rate of synapse assembly" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007416 ! synapse assembly -relationship: inheres_in GO:0007416 ! synapse assembly +intersection_of: RO:0000052 GO:0007416 ! inheres in synapse assembly +relationship: RO:0000052 GO:0007416 ! inheres in synapse assembly [Term] id: OBA:0004116 @@ -138292,7 +237643,7 @@ synonym: "rate of lymphocyte anergy" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0005004 ! lymphocyte anergy trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0002249 ! lymphocyte anergy +intersection_of: RO:0000052 GO:0002249 ! inheres in lymphocyte anergy [Term] id: OBA:0004117 @@ -138301,8 +237652,8 @@ def: "The morphology of a CD8-positive, alpha-beta T cell." [AUTO:patterns/patte synonym: "morphology of CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005717 ! alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell [Term] id: OBA:0004118 @@ -138312,8 +237663,8 @@ synonym: "deviation (from_normal) of late pro-B cell" EXACT [AUTO:patterns/patte is_a: OBA:1000574 ! B cell quality is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in CL:0002048 ! late pro-B cell -relationship: inheres_in CL:0002048 ! late pro-B cell +intersection_of: RO:0000052 CL:0002048 ! inheres in late pro-B cell +relationship: RO:0000052 CL:0002048 ! inheres in late pro-B cell [Term] id: OBA:0004119 @@ -138323,8 +237674,8 @@ synonym: "amount of amnion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000305 ! amnion -relationship: inheres_in UBERON:0000305 ! amnion +intersection_of: RO:0000052 UBERON:0000305 ! inheres in amnion +relationship: RO:0000052 UBERON:0000305 ! inheres in amnion [Term] id: OBA:0004120 @@ -138334,8 +237685,8 @@ synonym: "amount of MHC class II protein complex" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042613 ! MHC class II protein complex -relationship: inheres_in GO:0042613 ! MHC class II protein complex +intersection_of: RO:0000052 GO:0042613 ! inheres in MHC class II protein complex +relationship: RO:0000052 GO:0042613 ! inheres in MHC class II protein complex [Term] id: OBA:0004121 @@ -138345,7 +237696,7 @@ synonym: "altered number of of white pulp of spleen" EXACT [AUTO:patterns/patter is_a: OBA:VT0002357 ! spleen white pulp morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0001959 ! white pulp of spleen +intersection_of: RO:0000052 UBERON:0001959 ! inheres in white pulp of spleen [Term] id: OBA:0004122 @@ -138355,8 +237706,8 @@ synonym: "morphology of lysosome" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005764 ! lysosome -relationship: inheres_in GO:0005764 ! lysosome +intersection_of: RO:0000052 GO:0005764 ! inheres in lysosome +relationship: RO:0000052 GO:0005764 ! inheres in lysosome [Term] id: OBA:0004123 @@ -138366,8 +237717,8 @@ synonym: "rate of natural killer cell mediated cytotoxicity" EXACT [AUTO:pattern is_a: OBA:0002350 ! immune response rate is_a: OBA:VT0002419 ! innate immune response trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042267 ! natural killer cell mediated cytotoxicity -relationship: inheres_in GO:0042267 ! natural killer cell mediated cytotoxicity +intersection_of: RO:0000052 GO:0042267 ! inheres in natural killer cell mediated cytotoxicity +relationship: RO:0000052 GO:0042267 ! inheres in natural killer cell mediated cytotoxicity [Term] id: OBA:0004124 @@ -138377,8 +237728,8 @@ synonym: "morphology of melanosome" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0042470 ! melanosome -relationship: inheres_in GO:0042470 ! melanosome +intersection_of: RO:0000052 GO:0042470 ! inheres in melanosome +relationship: RO:0000052 GO:0042470 ! inheres in melanosome [Term] id: OBA:0004125 @@ -138387,8 +237738,8 @@ def: "The functionality of a CD8-positive, alpha-beta cytotoxic T cell." [AUTO:p synonym: "functionality of CD8-positive, alpha-beta cytotoxic T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003968 ! CD8-positive, alpha-beta T cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000794 ! CD8-positive, alpha-beta cytotoxic T cell -relationship: inheres_in CL:0000794 ! CD8-positive, alpha-beta cytotoxic T cell +intersection_of: RO:0000052 CL:0000794 ! inheres in CD8-positive, alpha-beta cytotoxic T cell +relationship: RO:0000052 CL:0000794 ! inheres in CD8-positive, alpha-beta cytotoxic T cell [Term] id: OBA:0004126 @@ -138397,8 +237748,8 @@ def: "The rate of a acute inflammatory response." [AUTO:patterns/patterns/entity synonym: "rate of acute inflammatory response" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003317 ! inflammatory response rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0002526 ! acute inflammatory response -relationship: inheres_in GO:0002526 ! acute inflammatory response +intersection_of: RO:0000052 GO:0002526 ! inheres in acute inflammatory response +relationship: RO:0000052 GO:0002526 ! inheres in acute inflammatory response [Term] id: OBA:0004127 @@ -138408,8 +237759,8 @@ synonym: "amount of double-positive, alpha-beta thymocyte" EXACT [AUTO:patterns/ is_a: OBA:0003541 ! thymocyte amount is_a: OBA:0005718 ! alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000809 ! double-positive, alpha-beta thymocyte -relationship: inheres_in CL:0000809 ! double-positive, alpha-beta thymocyte +intersection_of: RO:0000052 CL:0000809 ! inheres in double-positive, alpha-beta thymocyte +relationship: RO:0000052 CL:0000809 ! inheres in double-positive, alpha-beta thymocyte [Term] id: OBA:0004128 @@ -138419,7 +237770,7 @@ synonym: "rate of B cell proliferation" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003479 ! cell population proliferation rate is_a: OBA:VT0005153 ! B cell proliferation trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042100 ! B cell proliferation +intersection_of: RO:0000052 GO:0042100 ! inheres in B cell proliferation [Term] id: OBA:0004129 @@ -138429,8 +237780,8 @@ synonym: "rate of T cell proliferation" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003479 ! cell population proliferation rate is_a: OBA:VT0010184 ! lymphocyte proliferation trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0042098 ! T cell proliferation -relationship: inheres_in GO:0042098 ! T cell proliferation +intersection_of: RO:0000052 GO:0042098 ! inheres in T cell proliferation +relationship: RO:0000052 GO:0042098 ! inheres in T cell proliferation [Term] id: OBA:0004130 @@ -138439,8 +237790,8 @@ def: "The rate of a cardiac muscle contraction." [AUTO:patterns/patterns/entity_ synonym: "rate of cardiac muscle contraction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003544 ! muscle contraction rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060048 ! cardiac muscle contraction -relationship: inheres_in GO:0060048 ! cardiac muscle contraction +intersection_of: RO:0000052 GO:0060048 ! inheres in cardiac muscle contraction +relationship: RO:0000052 GO:0060048 ! inheres in cardiac muscle contraction [Term] id: OBA:0004131 @@ -138450,7 +237801,7 @@ synonym: "structure of gubernaculum (male or female)" EXACT [AUTO:patterns/patte is_a: OBA:VT0005149 ! gubernaculum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004346 ! gubernaculum (male or female) +intersection_of: RO:0000052 UBERON:0004346 ! inheres in gubernaculum (male or female) [Term] id: OBA:0004132 @@ -138460,8 +237811,8 @@ synonym: "position of intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000160 ! intestine -relationship: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine +relationship: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0004133 @@ -138471,8 +237822,8 @@ synonym: "deviation (from_normal) of establishment of blood-brain barrier" EXACT is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in GO:0060856 ! establishment of blood-brain barrier -relationship: inheres_in GO:0060856 ! establishment of blood-brain barrier +intersection_of: RO:0000052 GO:0060856 ! inheres in establishment of blood-brain barrier +relationship: RO:0000052 GO:0060856 ! inheres in establishment of blood-brain barrier [Term] id: OBA:0004134 @@ -138482,7 +237833,7 @@ synonym: "shape of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005681 ! upper lip morphology is_a: OBA:VT0003771 ! lip shape trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0004135 @@ -138492,7 +237843,7 @@ synonym: "closure of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0002092 ! eye morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0004136 @@ -138502,8 +237853,8 @@ synonym: "morphology of iris epithelium" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002506 ! iris epithelium -relationship: inheres_in UBERON:0002506 ! iris epithelium +intersection_of: RO:0000052 UBERON:0002506 ! inheres in iris epithelium +relationship: RO:0000052 UBERON:0002506 ! inheres in iris epithelium [Term] id: OBA:0004137 @@ -138513,7 +237864,7 @@ synonym: "spatial pattern of canal of Schlemm" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0005204 ! canal of Schlemm morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0004029 ! canal of Schlemm +intersection_of: RO:0000052 UBERON:0004029 ! inheres in canal of Schlemm [Term] id: OBA:0004138 @@ -138523,7 +237874,7 @@ synonym: "organization quality of epithelium of stomach" EXACT [AUTO:patterns/pa is_a: OBA:VT0000471 ! stomach epithelium morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0001276 ! epithelium of stomach +intersection_of: RO:0000052 UBERON:0001276 ! inheres in epithelium of stomach [Term] id: OBA:0004139 @@ -138533,7 +237884,7 @@ synonym: "size of epithelium of stomach" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000471 ! stomach epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001276 ! epithelium of stomach +intersection_of: RO:0000052 UBERON:0001276 ! inheres in epithelium of stomach [Term] id: OBA:0004140 @@ -138542,8 +237893,8 @@ def: "The morphology of a smooth muscle of eye." [AUTO:patterns/patterns/entity_ synonym: "morphology of smooth muscle of eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003386 ! smooth muscle of eye -relationship: inheres_in UBERON:0003386 ! smooth muscle of eye +intersection_of: RO:0000052 UBERON:0003386 ! inheres in smooth muscle of eye +relationship: RO:0000052 UBERON:0003386 ! inheres in smooth muscle of eye [Term] id: OBA:0004141 @@ -138553,8 +237904,8 @@ synonym: "morphology of renal glomerulus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000074 ! renal glomerulus -relationship: inheres_in UBERON:0000074 ! renal glomerulus +intersection_of: RO:0000052 UBERON:0000074 ! inheres in renal glomerulus +relationship: RO:0000052 UBERON:0000074 ! inheres in renal glomerulus [Term] id: OBA:0004142 @@ -138564,7 +237915,7 @@ synonym: "growth quality of occurrent of incisor tooth" EXACT [AUTO:patterns/pat is_a: OBA:1000578 ! incisor tooth quality is_a: PATO:0001433 ! growth quality of occurrent intersection_of: PATO:0001433 ! growth quality of occurrent -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0004143 @@ -138574,8 +237925,8 @@ synonym: "functionality of myeloid dendritic cell" EXACT [AUTO:patterns/patterns is_a: OBA:0003704 ! dendritic cell functionality is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000782 ! myeloid dendritic cell -relationship: inheres_in CL:0000782 ! myeloid dendritic cell +intersection_of: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell +relationship: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell [Term] id: OBA:0004144 @@ -138585,8 +237936,8 @@ synonym: "variability of color of coat of hair" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001611 ! variability of color intersection_of: PATO:0001611 ! variability of color -intersection_of: inheres_in UBERON:0010166 ! coat of hair -relationship: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair +relationship: RO:0000052 UBERON:0010166 ! inheres in coat of hair [Term] id: OBA:0004145 @@ -138596,7 +237947,7 @@ synonym: "onset quality of fertilization" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0005410 ! fertilization trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0009566 ! fertilization +intersection_of: RO:0000052 GO:0009566 ! inheres in fertilization [Term] id: OBA:0004146 @@ -138605,8 +237956,8 @@ def: "The amount of a oocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of oocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003699 ! germ cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000023 ! oocyte -relationship: inheres_in CL:0000023 ! oocyte +intersection_of: RO:0000052 CL:0000023 ! inheres in oocyte +relationship: RO:0000052 CL:0000023 ! inheres in oocyte [Term] id: OBA:0004147 @@ -138616,7 +237967,7 @@ synonym: "composition of multicellular organism" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003396 ! multicellular organism structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:0004148 @@ -138625,8 +237976,8 @@ def: "The functionality of a CD4-positive, alpha-beta T cell." [AUTO:patterns/pa synonym: "functionality of CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell [Term] id: OBA:0004149 @@ -138635,8 +237986,8 @@ def: "The functionality of a T-helper 1 cell." [AUTO:patterns/patterns/entity_at synonym: "functionality of T-helper 1 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004148 ! CD4-positive, alpha-beta T cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000545 ! T-helper 1 cell -relationship: inheres_in CL:0000545 ! T-helper 1 cell +intersection_of: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell +relationship: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell [Term] id: OBA:0004150 @@ -138645,8 +237996,8 @@ def: "The functionality of a T-helper 2 cell." [AUTO:patterns/patterns/entity_at synonym: "functionality of T-helper 2 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004148 ! CD4-positive, alpha-beta T cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000546 ! T-helper 2 cell -relationship: inheres_in CL:0000546 ! T-helper 2 cell +intersection_of: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell +relationship: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell [Term] id: OBA:0004151 @@ -138656,7 +238007,7 @@ synonym: "size of club cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:0005218 ! club cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000158 ! club cell +intersection_of: RO:0000052 CL:0000158 ! inheres in club cell [Term] id: OBA:0004152 @@ -138665,8 +238016,8 @@ def: "The size of a acinar cell." [AUTO:patterns/patterns/entity_attribute] synonym: "size of acinar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000622 ! acinar cell -relationship: inheres_in CL:0000622 ! acinar cell +intersection_of: RO:0000052 CL:0000622 ! inheres in acinar cell +relationship: RO:0000052 CL:0000622 ! inheres in acinar cell [Term] id: OBA:0004153 @@ -138676,7 +238027,7 @@ synonym: "concavity of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003638 ! cranial nerve II morphology is_a: PATO:0002005 ! concavity intersection_of: PATO:0002005 ! concavity -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0004154 @@ -138686,7 +238037,7 @@ synonym: "morphology of olfactory system" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0005394 ! olfactory system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005725 ! olfactory system +intersection_of: RO:0000052 UBERON:0005725 ! inheres in olfactory system [Term] id: OBA:0004155 @@ -138696,8 +238047,8 @@ synonym: "morphology of skeletal system" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001434 ! skeletal system -relationship: inheres_in UBERON:0001434 ! skeletal system +intersection_of: RO:0000052 UBERON:0001434 ! inheres in skeletal system +relationship: RO:0000052 UBERON:0001434 ! inheres in skeletal system [Term] id: OBA:0004156 @@ -138707,7 +238058,7 @@ synonym: "rate of liver regeneration" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0002658 ! liver regeneration trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0097421 ! liver regeneration +intersection_of: RO:0000052 GO:0097421 ! inheres in liver regeneration [Term] id: OBA:0004157 @@ -138717,7 +238068,7 @@ synonym: "size of pigmented layer of retina" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005201 ! retinal pigment epithelium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001782 ! pigmented layer of retina +intersection_of: RO:0000052 UBERON:0001782 ! inheres in pigmented layer of retina [Term] id: OBA:0004158 @@ -138727,7 +238078,7 @@ synonym: "rate of renal filtration" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000854 ! renal filtration quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0097205 ! renal filtration +intersection_of: RO:0000052 GO:0097205 ! inheres in renal filtration [Term] id: OBA:0004159 @@ -138737,7 +238088,7 @@ synonym: "frequency of respiratory gaseous exchange by respiratory system" EXACT is_a: OBA:1000805 ! respiratory gaseous exchange by respiratory system quality is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0007585 ! respiratory gaseous exchange by respiratory system +intersection_of: RO:0000052 GO:0007585 ! inheres in respiratory gaseous exchange by respiratory system [Term] id: OBA:0004160 @@ -138746,8 +238097,8 @@ def: "The morphology of a Meckel's cartilage." [AUTO:patterns/patterns/entity_at synonym: "morphology of Meckel's cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003107 ! Meckel's cartilage -relationship: inheres_in UBERON:0003107 ! Meckel's cartilage +intersection_of: RO:0000052 UBERON:0003107 ! inheres in Meckel's cartilage +relationship: RO:0000052 UBERON:0003107 ! inheres in Meckel's cartilage [Term] id: OBA:0004161 @@ -138756,8 +238107,8 @@ def: "The functionality of a blood vessel smooth muscle." [AUTO:patterns/pattern synonym: "functionality of blood vessel smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010111 ! smooth muscle physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004237 ! blood vessel smooth muscle -relationship: inheres_in UBERON:0004237 ! blood vessel smooth muscle +intersection_of: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle +relationship: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle [Term] id: OBA:0004162 @@ -138767,8 +238118,8 @@ synonym: "contractility of muscle organ" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:0004164 @@ -138778,7 +238129,7 @@ synonym: "degeneration of heart right ventricle" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0003920 ! right ventricle morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:0004165 @@ -138787,8 +238138,8 @@ def: "The morphology of a gonad mesenchyme." [AUTO:patterns/patterns/entity_attr synonym: "morphology of gonad mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003855 ! gonad mesenchyme -relationship: inheres_in UBERON:0003855 ! gonad mesenchyme +intersection_of: RO:0000052 UBERON:0003855 ! inheres in gonad mesenchyme +relationship: RO:0000052 UBERON:0003855 ! inheres in gonad mesenchyme [Term] id: OBA:0004166 @@ -138797,8 +238148,8 @@ def: "The functionality of a adipose tissue." [AUTO:patterns/patterns/entity_att synonym: "functionality of adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010064 ! connective tissue physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001013 ! adipose tissue -relationship: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue +relationship: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:0004167 @@ -138807,8 +238158,8 @@ def: "The functionality of a white adipose tissue." [AUTO:patterns/patterns/enti synonym: "functionality of white adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004166 ! adipose tissue functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001347 ! white adipose tissue -relationship: inheres_in UBERON:0001347 ! white adipose tissue +intersection_of: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue +relationship: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue [Term] id: OBA:0004168 @@ -138818,8 +238169,8 @@ synonym: "morphology of collection of basal ganglia" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010011 ! collection of basal ganglia -relationship: inheres_in UBERON:0010011 ! collection of basal ganglia +intersection_of: RO:0000052 UBERON:0010011 ! inheres in collection of basal ganglia +relationship: RO:0000052 UBERON:0010011 ! inheres in collection of basal ganglia [Term] id: OBA:0004169 @@ -138829,7 +238180,7 @@ synonym: "altered number of of strial intermediate cell" EXACT [AUTO:patterns/pa is_a: OBA:VT0004367 ! strial intermediate cell morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0002486 ! strial intermediate cell +intersection_of: RO:0000052 CL:0002486 ! inheres in strial intermediate cell [Term] id: OBA:0004170 @@ -138839,7 +238190,7 @@ synonym: "structure of vestibular membrane of cochlear duct" EXACT [AUTO:pattern is_a: OBA:VT0006021 ! Reissner membrane morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002281 ! vestibular membrane of cochlear duct +intersection_of: RO:0000052 UBERON:0002281 ! inheres in vestibular membrane of cochlear duct [Term] id: OBA:0004171 @@ -138849,8 +238200,8 @@ synonym: "rate of lung alveolus development" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048286 ! lung alveolus development -relationship: inheres_in GO:0048286 ! lung alveolus development +intersection_of: RO:0000052 GO:0048286 ! inheres in lung alveolus development +relationship: RO:0000052 GO:0048286 ! inheres in lung alveolus development [Term] id: OBA:0004172 @@ -138860,8 +238211,8 @@ synonym: "functionality of mitochondrion" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0005739 ! mitochondrion -relationship: inheres_in GO:0005739 ! mitochondrion +intersection_of: RO:0000052 GO:0005739 ! inheres in mitochondrion +relationship: RO:0000052 GO:0005739 ! inheres in mitochondrion [Term] id: OBA:0004173 @@ -138871,8 +238222,8 @@ synonym: "rate of mitochondrial fission" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0000266 ! mitochondrial fission -relationship: inheres_in GO:0000266 ! mitochondrial fission +intersection_of: RO:0000052 GO:0000266 ! inheres in mitochondrial fission +relationship: RO:0000052 GO:0000266 ! inheres in mitochondrial fission [Term] id: OBA:0004174 @@ -138881,8 +238232,8 @@ def: "The rate of a apoptotic process." [AUTO:patterns/patterns/entity_attribute synonym: "rate of apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005696 ! cell death rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006915 ! apoptotic process -relationship: inheres_in GO:0006915 ! apoptotic process +intersection_of: RO:0000052 GO:0006915 ! inheres in apoptotic process +relationship: RO:0000052 GO:0006915 ! inheres in apoptotic process [Term] id: OBA:0004175 @@ -138892,8 +238243,8 @@ synonym: "sufficiency of atrioventricular valve" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001626 ! sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0002133 ! atrioventricular valve -relationship: inheres_in UBERON:0002133 ! atrioventricular valve +intersection_of: RO:0000052 UBERON:0002133 ! inheres in atrioventricular valve +relationship: RO:0000052 UBERON:0002133 ! inheres in atrioventricular valve [Term] id: OBA:0004176 @@ -138903,8 +238254,8 @@ synonym: "sufficiency of semi-lunar valve" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001626 ! sufficiency intersection_of: PATO:0001626 ! sufficiency -intersection_of: inheres_in UBERON:0005623 ! semi-lunar valve -relationship: inheres_in UBERON:0005623 ! semi-lunar valve +intersection_of: RO:0000052 UBERON:0005623 ! inheres in semi-lunar valve +relationship: RO:0000052 UBERON:0005623 ! inheres in semi-lunar valve [Term] id: OBA:0004177 @@ -138913,8 +238264,8 @@ def: "The morphology of a endothelial cell of vascular tree." [AUTO:patterns/pat synonym: "morphology of endothelial cell of vascular tree" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002139 ! endothelial cell of vascular tree -relationship: inheres_in CL:0002139 ! endothelial cell of vascular tree +intersection_of: RO:0000052 CL:0002139 ! inheres in endothelial cell of vascular tree +relationship: RO:0000052 CL:0002139 ! inheres in endothelial cell of vascular tree [Term] id: OBA:0004178 @@ -138924,8 +238275,8 @@ synonym: "amount of endothelial cell of vascular tree" EXACT [AUTO:patterns/patt is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002139 ! endothelial cell of vascular tree -relationship: inheres_in CL:0002139 ! endothelial cell of vascular tree +intersection_of: RO:0000052 CL:0002139 ! inheres in endothelial cell of vascular tree +relationship: RO:0000052 CL:0002139 ! inheres in endothelial cell of vascular tree [Term] id: OBA:0004179 @@ -138935,7 +238286,7 @@ synonym: "symmetry of right cardiac atrium" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0000019 ! right atrium morphology trait is_a: OBA:VT0006061 ! atrium symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002078 ! right cardiac atrium +intersection_of: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium [Term] id: OBA:0004180 @@ -138944,8 +238295,8 @@ def: "The morphology of a retinal progenitor cell." [AUTO:patterns/patterns/enti synonym: "morphology of retinal progenitor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002400 ! multipotent stem cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002672 ! retinal progenitor cell -relationship: inheres_in CL:0002672 ! retinal progenitor cell +intersection_of: RO:0000052 CL:0002672 ! inheres in retinal progenitor cell +relationship: RO:0000052 CL:0002672 ! inheres in retinal progenitor cell [Term] id: OBA:0004181 @@ -138955,8 +238306,8 @@ synonym: "morphology of retinal bipolar neuron" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003799 ! glutamatergic neuron morphology is_a: OBA:VT0006004 ! interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000748 ! retinal bipolar neuron -relationship: inheres_in CL:0000748 ! retinal bipolar neuron +intersection_of: RO:0000052 CL:0000748 ! inheres in retinal bipolar neuron +relationship: RO:0000052 CL:0000748 ! inheres in retinal bipolar neuron [Term] id: OBA:0004182 @@ -138965,8 +238316,8 @@ def: "The morphology of a rod bipolar cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of rod bipolar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004181 ! retinal bipolar neuron morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000751 ! rod bipolar cell -relationship: inheres_in CL:0000751 ! rod bipolar cell +intersection_of: RO:0000052 CL:0000751 ! inheres in rod bipolar cell +relationship: RO:0000052 CL:0000751 ! inheres in rod bipolar cell [Term] id: OBA:0004183 @@ -138975,8 +238326,8 @@ def: "The morphology of a cone retinal bipolar cell." [AUTO:patterns/patterns/en synonym: "morphology of cone retinal bipolar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004181 ! retinal bipolar neuron morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000752 ! cone retinal bipolar cell -relationship: inheres_in CL:0000752 ! cone retinal bipolar cell +intersection_of: RO:0000052 CL:0000752 ! inheres in cone retinal bipolar cell +relationship: RO:0000052 CL:0000752 ! inheres in cone retinal bipolar cell [Term] id: OBA:0004184 @@ -138986,8 +238337,8 @@ synonym: "functionality of blood-cerebrospinal fluid barrier" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0003210 ! blood-cerebrospinal fluid barrier -relationship: inheres_in UBERON:0003210 ! blood-cerebrospinal fluid barrier +intersection_of: RO:0000052 UBERON:0003210 ! inheres in blood-cerebrospinal fluid barrier +relationship: RO:0000052 UBERON:0003210 ! inheres in blood-cerebrospinal fluid barrier [Term] id: OBA:0004185 @@ -138997,7 +238348,7 @@ synonym: "size of fat cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0004128 ! adipocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000136 ! fat cell +intersection_of: RO:0000052 CL:0000136 ! inheres in fat cell [Term] id: OBA:0004186 @@ -139007,8 +238358,8 @@ synonym: "amount of cerebellum lobule" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004004 ! cerebellum lobule -relationship: inheres_in UBERON:0004004 ! cerebellum lobule +intersection_of: RO:0000052 UBERON:0004004 ! inheres in cerebellum lobule +relationship: RO:0000052 UBERON:0004004 ! inheres in cerebellum lobule [Term] id: OBA:0004187 @@ -139018,7 +238369,7 @@ synonym: "size of granular layer of cerebellar cortex" EXACT [AUTO:patterns/patt is_a: OBA:VT0000886 ! cerebellar granule layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002956 ! granular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002956 ! inheres in granular layer of cerebellar cortex [Term] id: OBA:0004188 @@ -139028,8 +238379,8 @@ synonym: "occurrence of cardiac muscle contraction" EXACT [AUTO:patterns/pattern is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060048 ! cardiac muscle contraction -relationship: inheres_in GO:0060048 ! cardiac muscle contraction +intersection_of: RO:0000052 GO:0060048 ! inheres in cardiac muscle contraction +relationship: RO:0000052 GO:0060048 ! inheres in cardiac muscle contraction [Term] id: OBA:0004189 @@ -139039,8 +238390,8 @@ synonym: "position of aortic valve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002137 ! aortic valve -relationship: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve +relationship: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0004190 @@ -139050,7 +238401,7 @@ synonym: "closure of mitral valve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000033 ! mitral valve morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0004191 @@ -139060,7 +238411,7 @@ synonym: "closure of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000036 ! tricuspid valve morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0004192 @@ -139070,7 +238421,7 @@ synonym: "structure of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000036 ! tricuspid valve morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0004193 @@ -139080,8 +238431,8 @@ synonym: "position of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve -relationship: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve +relationship: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0004194 @@ -139091,7 +238442,7 @@ synonym: "closure of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000044 ! pulmonary valve morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0004195 @@ -139101,7 +238452,7 @@ synonym: "composition of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002235 ! pulmonary valve structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0004196 @@ -139111,7 +238462,7 @@ synonym: "composition of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004192 ! tricuspid valve structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0004197 @@ -139121,7 +238472,7 @@ synonym: "closure of artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003467 ! blood vessel closure is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001637 ! artery +intersection_of: RO:0000052 UBERON:0001637 ! inheres in artery [Term] id: OBA:0004198 @@ -139131,7 +238482,7 @@ synonym: "closure of vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003467 ! blood vessel closure is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001638 ! vein +intersection_of: RO:0000052 UBERON:0001638 ! inheres in vein [Term] id: OBA:0004199 @@ -139141,8 +238492,8 @@ synonym: "conductivity of atrioventricular node" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0002352 ! atrioventricular node -relationship: inheres_in UBERON:0002352 ! atrioventricular node +intersection_of: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node +relationship: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node [Term] id: OBA:0004200 @@ -139152,8 +238503,8 @@ synonym: "conductivity of sinoatrial node" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0002351 ! sinoatrial node -relationship: inheres_in UBERON:0002351 ! sinoatrial node +intersection_of: RO:0000052 UBERON:0002351 ! inheres in sinoatrial node +relationship: RO:0000052 UBERON:0002351 ! inheres in sinoatrial node [Term] id: OBA:0004201 @@ -139163,7 +238514,7 @@ synonym: "functionality of lateral rectus extra-ocular muscle" EXACT [AUTO:patte is_a: OBA:0003691 ! muscle organ functionality is_a: OBA:1000393 ! lateral rectus extra-ocular muscle quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001603 ! lateral rectus extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001603 ! inheres in lateral rectus extra-ocular muscle [Term] id: OBA:0004202 @@ -139172,8 +238523,8 @@ def: "The functionality of a medial rectus extraocular muscle." [AUTO:patterns/p synonym: "functionality of medial rectus extraocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003691 ! muscle organ functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001602 ! medial rectus extraocular muscle -relationship: inheres_in UBERON:0001602 ! medial rectus extraocular muscle +intersection_of: RO:0000052 UBERON:0001602 ! inheres in medial rectus extraocular muscle +relationship: RO:0000052 UBERON:0001602 ! inheres in medial rectus extraocular muscle [Term] id: OBA:0004203 @@ -139182,8 +238533,8 @@ def: "The movement behavioral quality of a superior rectus extraocular muscle." synonym: "movement behavioral quality of superior rectus extraocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002121 ! extra-ocular muscle movement behavioral quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0006323 ! superior rectus extraocular muscle -relationship: inheres_in UBERON:0006323 ! superior rectus extraocular muscle +intersection_of: RO:0000052 UBERON:0006323 ! inheres in superior rectus extraocular muscle +relationship: RO:0000052 UBERON:0006323 ! inheres in superior rectus extraocular muscle [Term] id: OBA:0004204 @@ -139193,7 +238544,7 @@ synonym: "degeneration of optic choroid" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0005098 ! choroid morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001776 ! optic choroid +intersection_of: RO:0000052 UBERON:0001776 ! inheres in optic choroid [Term] id: OBA:0004205 @@ -139203,7 +238554,7 @@ synonym: "composition of camera-type eye" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0002092 ! eye morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0004206 @@ -139213,7 +238564,7 @@ synonym: "degeneration of cranial nerve II" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002181 ! cranial nerve II structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0004207 @@ -139223,7 +238574,7 @@ synonym: "curvature of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003638 ! cranial nerve II morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0004208 @@ -139233,7 +238584,7 @@ synonym: "composition of cranial nerve II" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002181 ! cranial nerve II structure is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000941 ! cranial nerve II +intersection_of: RO:0000052 UBERON:0000941 ! inheres in cranial nerve II [Term] id: OBA:0004209 @@ -139243,7 +238594,7 @@ synonym: "wholeness of camera-type eye" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0002092 ! eye morphology trait is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0004210 @@ -139253,7 +238604,7 @@ synonym: "color of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001317 ! pupil morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:0004211 @@ -139263,7 +238614,7 @@ synonym: "movement behavioral quality of lateral rectus extra-ocular muscle" EXA is_a: OBA:0002121 ! extra-ocular muscle movement behavioral quality is_a: OBA:1000393 ! lateral rectus extra-ocular muscle quality intersection_of: PATO:0002076 ! movement behavioral quality -intersection_of: inheres_in UBERON:0001603 ! lateral rectus extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001603 ! inheres in lateral rectus extra-ocular muscle [Term] id: OBA:0004212 @@ -139273,7 +238624,7 @@ synonym: "curvature of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002192 ! digit shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:0004213 @@ -139283,8 +238634,8 @@ synonym: "morphology of dorsal horn of spinal cord" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002256 ! dorsal horn of spinal cord -relationship: inheres_in UBERON:0002256 ! dorsal horn of spinal cord +intersection_of: RO:0000052 UBERON:0002256 ! inheres in dorsal horn of spinal cord +relationship: RO:0000052 UBERON:0002256 ! inheres in dorsal horn of spinal cord [Term] id: OBA:0004214 @@ -139294,7 +238645,7 @@ synonym: "size of internal ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000026 ! inner ear morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001846 ! internal ear +intersection_of: RO:0000052 UBERON:0001846 ! inheres in internal ear [Term] id: OBA:0004215 @@ -139305,7 +238656,7 @@ is_a: OBA:0003436 ! bony otic capsule morphology is_a: OBA:1000138 ! bone element size is_a: OBA:VT0001456 ! otic capsule size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005411 ! bony otic capsule +intersection_of: RO:0000052 UBERON:0005411 ! inheres in bony otic capsule [Term] id: OBA:0004216 @@ -139315,8 +238666,8 @@ synonym: "structure of olfactory placode" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003050 ! olfactory placode -relationship: inheres_in UBERON:0003050 ! olfactory placode +intersection_of: RO:0000052 UBERON:0003050 ! inheres in olfactory placode +relationship: RO:0000052 UBERON:0003050 ! inheres in olfactory placode [Term] id: OBA:0004217 @@ -139326,8 +238677,8 @@ synonym: "amount of olfactory placode" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003050 ! olfactory placode -relationship: inheres_in UBERON:0003050 ! olfactory placode +intersection_of: RO:0000052 UBERON:0003050 ! inheres in olfactory placode +relationship: RO:0000052 UBERON:0003050 ! inheres in olfactory placode [Term] id: OBA:0004218 @@ -139337,8 +238688,8 @@ synonym: "amount of optic vesicle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004128 ! optic vesicle -relationship: inheres_in UBERON:0004128 ! optic vesicle +intersection_of: RO:0000052 UBERON:0004128 ! inheres in optic vesicle +relationship: RO:0000052 UBERON:0004128 ! inheres in optic vesicle [Term] id: OBA:0004219 @@ -139348,8 +238699,8 @@ synonym: "amount of sclerotome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003089 ! sclerotome -relationship: inheres_in UBERON:0003089 ! sclerotome +intersection_of: RO:0000052 UBERON:0003089 ! inheres in sclerotome +relationship: RO:0000052 UBERON:0003089 ! inheres in sclerotome [Term] id: OBA:0004220 @@ -139359,8 +238710,8 @@ synonym: "morphology of entorhinal cortex" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002728 ! entorhinal cortex -relationship: inheres_in UBERON:0002728 ! entorhinal cortex +intersection_of: RO:0000052 UBERON:0002728 ! inheres in entorhinal cortex +relationship: RO:0000052 UBERON:0002728 ! inheres in entorhinal cortex [Term] id: OBA:0004221 @@ -139370,8 +238721,8 @@ synonym: "morphology of mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003104 ! mesenchyme -relationship: inheres_in UBERON:0003104 ! mesenchyme +intersection_of: RO:0000052 UBERON:0003104 ! inheres in mesenchyme +relationship: RO:0000052 UBERON:0003104 ! inheres in mesenchyme [Term] id: OBA:0004222 @@ -139380,8 +238731,8 @@ def: "The morphology of a head ectomesenchyme." [AUTO:patterns/patterns/entity_a synonym: "morphology of head ectomesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005369 ! head mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004031 ! head ectomesenchyme -relationship: inheres_in UBERON:0004031 ! head ectomesenchyme +intersection_of: RO:0000052 UBERON:0004031 ! inheres in head ectomesenchyme +relationship: RO:0000052 UBERON:0004031 ! inheres in head ectomesenchyme [Term] id: OBA:0004223 @@ -139390,8 +238741,8 @@ def: "The morphology of a nerve fiber layer of retina." [AUTO:patterns/patterns/ synonym: "morphology of nerve fiber layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001793 ! nerve fiber layer of retina -relationship: inheres_in UBERON:0001793 ! nerve fiber layer of retina +intersection_of: RO:0000052 UBERON:0001793 ! inheres in nerve fiber layer of retina +relationship: RO:0000052 UBERON:0001793 ! inheres in nerve fiber layer of retina [Term] id: OBA:0004224 @@ -139401,8 +238752,8 @@ synonym: "morphology of optic eminence" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004348 ! optic eminence -relationship: inheres_in UBERON:0004348 ! optic eminence +intersection_of: RO:0000052 UBERON:0004348 ! inheres in optic eminence +relationship: RO:0000052 UBERON:0004348 ! inheres in optic eminence [Term] id: OBA:0004225 @@ -139412,8 +238763,8 @@ synonym: "morphology of olfactory pit" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005870 ! olfactory pit -relationship: inheres_in UBERON:0005870 ! olfactory pit +intersection_of: RO:0000052 UBERON:0005870 ! inheres in olfactory pit +relationship: RO:0000052 UBERON:0005870 ! inheres in olfactory pit [Term] id: OBA:0004226 @@ -139423,8 +238774,8 @@ synonym: "structure of perichondrium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0001248 ! connective tissue morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002222 ! perichondrium -relationship: inheres_in UBERON:0002222 ! perichondrium +intersection_of: RO:0000052 UBERON:0002222 ! inheres in perichondrium +relationship: RO:0000052 UBERON:0002222 ! inheres in perichondrium [Term] id: OBA:0004227 @@ -139434,7 +238785,7 @@ synonym: "rate of sensory perception of sound" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000931 ! sensory perception of sound quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007605 ! sensory perception of sound +intersection_of: RO:0000052 GO:0007605 ! inheres in sensory perception of sound [Term] id: OBA:0004228 @@ -139443,8 +238794,8 @@ def: "The morphology of a pharyngeal arch 1." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal arch 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004362 ! pharyngeal arch 1 -relationship: inheres_in UBERON:0004362 ! pharyngeal arch 1 +intersection_of: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 +relationship: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 [Term] id: OBA:0004229 @@ -139453,8 +238804,8 @@ def: "The morphology of a pharyngeal arch 2." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal arch 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003066 ! pharyngeal arch 2 -relationship: inheres_in UBERON:0003066 ! pharyngeal arch 2 +intersection_of: RO:0000052 UBERON:0003066 ! inheres in pharyngeal arch 2 +relationship: RO:0000052 UBERON:0003066 ! inheres in pharyngeal arch 2 [Term] id: OBA:0004230 @@ -139463,8 +238814,8 @@ def: "The morphology of a pharyngeal arch 3." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal arch 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003114 ! pharyngeal arch 3 -relationship: inheres_in UBERON:0003114 ! pharyngeal arch 3 +intersection_of: RO:0000052 UBERON:0003114 ! inheres in pharyngeal arch 3 +relationship: RO:0000052 UBERON:0003114 ! inheres in pharyngeal arch 3 [Term] id: OBA:0004231 @@ -139473,8 +238824,8 @@ def: "The morphology of a pharyngeal arch 6." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal arch 6" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003117 ! pharyngeal arch 6 -relationship: inheres_in UBERON:0003117 ! pharyngeal arch 6 +intersection_of: RO:0000052 UBERON:0003117 ! inheres in pharyngeal arch 6 +relationship: RO:0000052 UBERON:0003117 ! inheres in pharyngeal arch 6 [Term] id: OBA:0004232 @@ -139484,7 +238835,7 @@ synonym: "size of pharyngeal arch 1" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003881 ! pharyngeal arch size is_a: OBA:0004228 ! pharyngeal arch 1 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004362 ! pharyngeal arch 1 +intersection_of: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 [Term] id: OBA:0004233 @@ -139493,8 +238844,8 @@ def: "The amount of a pharyngeal arch 1." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pharyngeal arch 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003882 ! pharyngeal arch amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004362 ! pharyngeal arch 1 -relationship: inheres_in UBERON:0004362 ! pharyngeal arch 1 +intersection_of: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 +relationship: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 [Term] id: OBA:0004234 @@ -139504,7 +238855,7 @@ synonym: "size of pharyngeal arch 2" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003881 ! pharyngeal arch size is_a: OBA:0004229 ! pharyngeal arch 2 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003066 ! pharyngeal arch 2 +intersection_of: RO:0000052 UBERON:0003066 ! inheres in pharyngeal arch 2 [Term] id: OBA:0004235 @@ -139513,8 +238864,8 @@ def: "The amount of a pharyngeal arch 2." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pharyngeal arch 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003882 ! pharyngeal arch amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003066 ! pharyngeal arch 2 -relationship: inheres_in UBERON:0003066 ! pharyngeal arch 2 +intersection_of: RO:0000052 UBERON:0003066 ! inheres in pharyngeal arch 2 +relationship: RO:0000052 UBERON:0003066 ! inheres in pharyngeal arch 2 [Term] id: OBA:0004236 @@ -139523,8 +238874,8 @@ def: "The morphology of a pharyngeal arch 4." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal arch 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003750 ! pharyngeal arch morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003115 ! pharyngeal arch 4 -relationship: inheres_in UBERON:0003115 ! pharyngeal arch 4 +intersection_of: RO:0000052 UBERON:0003115 ! inheres in pharyngeal arch 4 +relationship: RO:0000052 UBERON:0003115 ! inheres in pharyngeal arch 4 [Term] id: OBA:0004237 @@ -139533,8 +238884,8 @@ def: "The morphology of a pharyngeal arch artery 4." [AUTO:patterns/patterns/ent synonym: "morphology of pharyngeal arch artery 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003121 ! pharyngeal arch artery 4 -relationship: inheres_in UBERON:0003121 ! pharyngeal arch artery 4 +intersection_of: RO:0000052 UBERON:0003121 ! inheres in pharyngeal arch artery 4 +relationship: RO:0000052 UBERON:0003121 ! inheres in pharyngeal arch artery 4 [Term] id: OBA:0004238 @@ -139543,8 +238894,8 @@ def: "The morphology of a pharyngeal arch artery 6." [AUTO:patterns/patterns/ent synonym: "morphology of pharyngeal arch artery 6" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003123 ! pharyngeal arch artery 6 -relationship: inheres_in UBERON:0003123 ! pharyngeal arch artery 6 +intersection_of: RO:0000052 UBERON:0003123 ! inheres in pharyngeal arch artery 6 +relationship: RO:0000052 UBERON:0003123 ! inheres in pharyngeal arch artery 6 [Term] id: OBA:0004239 @@ -139553,8 +238904,8 @@ def: "The morphology of a pharyngeal arch artery 3." [AUTO:patterns/patterns/ent synonym: "morphology of pharyngeal arch artery 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003120 ! pharyngeal arch artery 3 -relationship: inheres_in UBERON:0003120 ! pharyngeal arch artery 3 +intersection_of: RO:0000052 UBERON:0003120 ! inheres in pharyngeal arch artery 3 +relationship: RO:0000052 UBERON:0003120 ! inheres in pharyngeal arch artery 3 [Term] id: OBA:0004240 @@ -139563,8 +238914,8 @@ def: "The morphology of a female germ cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of female germ cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002208 ! germ cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000021 ! female germ cell -relationship: inheres_in CL:0000021 ! female germ cell +intersection_of: RO:0000052 CL:0000021 ! inheres in female germ cell +relationship: RO:0000052 CL:0000021 ! inheres in female germ cell [Term] id: OBA:0004241 @@ -139574,7 +238925,7 @@ synonym: "amount of strand of auchene hair" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000665 ! strand of auchene hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010510 ! strand of auchene hair +intersection_of: RO:0000052 UBERON:0010510 ! inheres in strand of auchene hair [Term] id: OBA:0004242 @@ -139584,7 +238935,7 @@ synonym: "amount of strand of awl hair" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000674 ! strand of awl hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010511 ! strand of awl hair +intersection_of: RO:0000052 UBERON:0010511 ! inheres in strand of awl hair [Term] id: OBA:0004243 @@ -139594,7 +238945,7 @@ synonym: "amount of strand of guard hair" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000934 ! strand of guard hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010512 ! strand of guard hair +intersection_of: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair [Term] id: OBA:0004244 @@ -139604,7 +238955,7 @@ synonym: "amount of strand of zigzag hair" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000813 ! strand of zigzag hair quality is_a: OBA:VT0000268 ! vibrissa quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010513 ! strand of zigzag hair +intersection_of: RO:0000052 UBERON:0010513 ! inheres in strand of zigzag hair [Term] id: OBA:0004245 @@ -139614,7 +238965,7 @@ synonym: "functionality of placenta" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000620 ! placenta quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:0004246 @@ -139623,8 +238974,8 @@ def: "The morphology of a spermatogonium." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of spermatogonium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003333 ! male germ cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000020 ! spermatogonium -relationship: inheres_in CL:0000020 ! spermatogonium +intersection_of: RO:0000052 CL:0000020 ! inheres in spermatogonium +relationship: RO:0000052 CL:0000020 ! inheres in spermatogonium [Term] id: OBA:0004247 @@ -139633,8 +238984,8 @@ def: "The morphology of a spermatocyte." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of spermatocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003333 ! male germ cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000017 ! spermatocyte -relationship: inheres_in CL:0000017 ! spermatocyte +intersection_of: RO:0000052 CL:0000017 ! inheres in spermatocyte +relationship: RO:0000052 CL:0000017 ! inheres in spermatocyte [Term] id: OBA:0004248 @@ -139643,8 +238994,8 @@ def: "The morphology of a spermatid." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of spermatid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003333 ! male germ cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000018 ! spermatid -relationship: inheres_in CL:0000018 ! spermatid +intersection_of: RO:0000052 CL:0000018 ! inheres in spermatid +relationship: RO:0000052 CL:0000018 ! inheres in spermatid [Term] id: OBA:0004249 @@ -139653,8 +239004,8 @@ def: "The morphology of a lung epithelium." [AUTO:patterns/patterns/entity_attri synonym: "morphology of lung epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000115 ! lung epithelium -relationship: inheres_in UBERON:0000115 ! lung epithelium +intersection_of: RO:0000052 UBERON:0000115 ! inheres in lung epithelium +relationship: RO:0000052 UBERON:0000115 ! inheres in lung epithelium [Term] id: OBA:0004250 @@ -139664,8 +239015,8 @@ synonym: "amount of somite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002329 ! somite -relationship: inheres_in UBERON:0002329 ! somite +intersection_of: RO:0000052 UBERON:0002329 ! inheres in somite +relationship: RO:0000052 UBERON:0002329 ! inheres in somite [Term] id: OBA:0004251 @@ -139674,8 +239025,8 @@ def: "The morphology of a nucleus pulposus." [AUTO:patterns/patterns/entity_attr synonym: "morphology of nucleus pulposus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002242 ! nucleus pulposus -relationship: inheres_in UBERON:0002242 ! nucleus pulposus +intersection_of: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus +relationship: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus [Term] id: OBA:0004252 @@ -139685,8 +239036,8 @@ synonym: "amount of nucleus pulposus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002242 ! nucleus pulposus -relationship: inheres_in UBERON:0002242 ! nucleus pulposus +intersection_of: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus +relationship: RO:0000052 UBERON:0002242 ! inheres in nucleus pulposus [Term] id: OBA:0004253 @@ -139696,7 +239047,7 @@ synonym: "organization quality of epiphyseal plate" EXACT [AUTO:patterns/pattern is_a: OBA:VT0003055 ! epiphyseal plate morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0002516 ! epiphyseal plate +intersection_of: RO:0000052 UBERON:0002516 ! inheres in epiphyseal plate [Term] id: OBA:0004254 @@ -139706,7 +239057,7 @@ synonym: "size of epiphyseal plate" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003727 ! cartilage tissue size is_a: OBA:VT0003055 ! epiphyseal plate morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002516 ! epiphyseal plate +intersection_of: RO:0000052 UBERON:0002516 ! inheres in epiphyseal plate [Term] id: OBA:0004255 @@ -139716,8 +239067,8 @@ synonym: "morphology of long bone epiphyseal ossification zone" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003958 ! long bone epiphyseal ossification zone -relationship: inheres_in UBERON:0003958 ! long bone epiphyseal ossification zone +intersection_of: RO:0000052 UBERON:0003958 ! inheres in long bone epiphyseal ossification zone +relationship: RO:0000052 UBERON:0003958 ! inheres in long bone epiphyseal ossification zone [Term] id: OBA:0004256 @@ -139726,8 +239077,8 @@ def: "The amount of a preputial gland." [AUTO:patterns/patterns/entity_attribute synonym: "amount of preputial gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005763 ! sebaceous gland amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000359 ! preputial gland -relationship: inheres_in UBERON:0000359 ! preputial gland +intersection_of: RO:0000052 UBERON:0000359 ! inheres in preputial gland +relationship: RO:0000052 UBERON:0000359 ! inheres in preputial gland [Term] id: OBA:0004257 @@ -139737,7 +239088,7 @@ synonym: "size of molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000112 ! tooth size is_a: OBA:VT0002689 ! molar morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:0004258 @@ -139746,8 +239097,8 @@ def: "The morphology of a common myeloid progenitor." [AUTO:patterns/patterns/en synonym: "morphology of common myeloid progenitor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000049 ! common myeloid progenitor -relationship: inheres_in CL:0000049 ! common myeloid progenitor +intersection_of: RO:0000052 CL:0000049 ! inheres in common myeloid progenitor +relationship: RO:0000052 CL:0000049 ! inheres in common myeloid progenitor [Term] id: OBA:0004259 @@ -139756,8 +239107,8 @@ def: "The rate of a T cell apoptotic process." [AUTO:patterns/patterns/entity_at synonym: "rate of T cell apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002351 ! lymphocyte apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070231 ! T cell apoptotic process -relationship: inheres_in GO:0070231 ! T cell apoptotic process +intersection_of: RO:0000052 GO:0070231 ! inheres in T cell apoptotic process +relationship: RO:0000052 GO:0070231 ! inheres in T cell apoptotic process [Term] id: OBA:0004260 @@ -139767,8 +239118,8 @@ synonym: "morphology of rete testis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003959 ! rete testis -relationship: inheres_in UBERON:0003959 ! rete testis +intersection_of: RO:0000052 UBERON:0003959 ! inheres in rete testis +relationship: RO:0000052 UBERON:0003959 ! inheres in rete testis [Term] id: OBA:0004261 @@ -139777,8 +239128,8 @@ def: "The morphology of a peritubular myoid cell." [AUTO:patterns/patterns/entit synonym: "morphology of peritubular myoid cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002481 ! peritubular myoid cell -relationship: inheres_in CL:0002481 ! peritubular myoid cell +intersection_of: RO:0000052 CL:0002481 ! inheres in peritubular myoid cell +relationship: RO:0000052 CL:0002481 ! inheres in peritubular myoid cell [Term] id: OBA:0004262 @@ -139788,7 +239139,7 @@ synonym: "size of rete testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004260 ! rete testis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003959 ! rete testis +intersection_of: RO:0000052 UBERON:0003959 ! inheres in rete testis [Term] id: OBA:0004263 @@ -139798,8 +239149,8 @@ synonym: "amount of testis sex cord" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005297 ! testis sex cord -relationship: inheres_in UBERON:0005297 ! testis sex cord +intersection_of: RO:0000052 UBERON:0005297 ! inheres in testis sex cord +relationship: RO:0000052 UBERON:0005297 ! inheres in testis sex cord [Term] id: OBA:0004264 @@ -139809,7 +239160,7 @@ synonym: "altered number of of Mullerian duct" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0003826 ! Mullerian duct morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0003890 ! Mullerian duct +intersection_of: RO:0000052 UBERON:0003890 ! inheres in Mullerian duct [Term] id: OBA:0004265 @@ -139819,7 +239170,7 @@ synonym: "degeneration of Mullerian duct" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0003826 ! Mullerian duct morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0003890 ! Mullerian duct +intersection_of: RO:0000052 UBERON:0003890 ! inheres in Mullerian duct [Term] id: OBA:0004266 @@ -139829,7 +239180,7 @@ synonym: "displaced of Leydig cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000182 ! Leydig cell quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000178 ! Leydig cell +intersection_of: RO:0000052 CL:0000178 ! inheres in Leydig cell [Term] id: OBA:0004267 @@ -139839,8 +239190,8 @@ synonym: "displaced of Sertoli cell" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000076 ! attribute of cell is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000216 ! Sertoli cell -relationship: inheres_in CL:0000216 ! Sertoli cell +intersection_of: RO:0000052 CL:0000216 ! inheres in Sertoli cell +relationship: RO:0000052 CL:0000216 ! inheres in Sertoli cell [Term] id: OBA:0004268 @@ -139849,8 +239200,8 @@ def: "The morphology of a hyaline cartilage tissue." [AUTO:patterns/patterns/ent synonym: "morphology of hyaline cartilage tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001994 ! hyaline cartilage tissue -relationship: inheres_in UBERON:0001994 ! hyaline cartilage tissue +intersection_of: RO:0000052 UBERON:0001994 ! inheres in hyaline cartilage tissue +relationship: RO:0000052 UBERON:0001994 ! inheres in hyaline cartilage tissue [Term] id: OBA:0004269 @@ -139859,8 +239210,8 @@ def: "The morphology of a elastic cartilage tissue." [AUTO:patterns/patterns/ent synonym: "morphology of elastic cartilage tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001996 ! elastic cartilage tissue -relationship: inheres_in UBERON:0001996 ! elastic cartilage tissue +intersection_of: RO:0000052 UBERON:0001996 ! inheres in elastic cartilage tissue +relationship: RO:0000052 UBERON:0001996 ! inheres in elastic cartilage tissue [Term] id: OBA:0004270 @@ -139869,8 +239220,8 @@ def: "The morphology of a fibrocartilage." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of fibrocartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001995 ! fibrocartilage -relationship: inheres_in UBERON:0001995 ! fibrocartilage +intersection_of: RO:0000052 UBERON:0001995 ! inheres in fibrocartilage +relationship: RO:0000052 UBERON:0001995 ! inheres in fibrocartilage [Term] id: OBA:0004271 @@ -139879,8 +239230,8 @@ def: "The morphology of a articular cartilage of joint." [AUTO:patterns/patterns synonym: "morphology of articular cartilage of joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004268 ! hyaline cartilage tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010996 ! articular cartilage of joint -relationship: inheres_in UBERON:0010996 ! articular cartilage of joint +intersection_of: RO:0000052 UBERON:0010996 ! inheres in articular cartilage of joint +relationship: RO:0000052 UBERON:0010996 ! inheres in articular cartilage of joint [Term] id: OBA:0004272 @@ -139890,18 +239241,19 @@ synonym: "acidity of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001842 ! acidity intersection_of: PATO:0001842 ! acidity -intersection_of: inheres_in UBERON:0000945 ! stomach -relationship: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach +relationship: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:0004273 -name: cell aging onset quality -def: "The onset quality of a cell aging." [AUTO:patterns/patterns/entity_attribute] -synonym: "onset quality of cell aging" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0003870 ! aging onset quality +name: cellular senescence onset quality +def: "The onset quality of a cellular senescence." [AUTO:patterns/patterns/entity_attribute] +synonym: "onset quality of cellular senescence" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:VT0002121 ! metabolism trait +is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007569 ! cell aging -relationship: inheres_in GO:0007569 ! cell aging +intersection_of: RO:0000052 GO:0090398 ! inheres in cellular senescence +relationship: RO:0000052 GO:0090398 ! inheres in cellular senescence [Term] id: OBA:0004274 @@ -139910,8 +239262,8 @@ def: "The morphology of a female inguinal canal." [AUTO:patterns/patterns/entity synonym: "morphology of female inguinal canal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003673 ! inguinal canal morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004353 ! female inguinal canal -relationship: inheres_in UBERON:0004353 ! female inguinal canal +intersection_of: RO:0000052 UBERON:0004353 ! inheres in female inguinal canal +relationship: RO:0000052 UBERON:0004353 ! inheres in female inguinal canal [Term] id: OBA:0004275 @@ -139920,8 +239272,8 @@ def: "The morphology of a male inguinal canal." [AUTO:patterns/patterns/entity_a synonym: "morphology of male inguinal canal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003673 ! inguinal canal morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004354 ! male inguinal canal -relationship: inheres_in UBERON:0004354 ! male inguinal canal +intersection_of: RO:0000052 UBERON:0004354 ! inheres in male inguinal canal +relationship: RO:0000052 UBERON:0004354 ! inheres in male inguinal canal [Term] id: OBA:0004276 @@ -139931,8 +239283,8 @@ synonym: "morphology of brain white matter" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003544 ! brain white matter -relationship: inheres_in UBERON:0003544 ! brain white matter +intersection_of: RO:0000052 UBERON:0003544 ! inheres in brain white matter +relationship: RO:0000052 UBERON:0003544 ! inheres in brain white matter [Term] id: OBA:0004277 @@ -139942,8 +239294,8 @@ synonym: "morphology of white matter of spinal cord" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002318 ! white matter of spinal cord -relationship: inheres_in UBERON:0002318 ! white matter of spinal cord +intersection_of: RO:0000052 UBERON:0002318 ! inheres in white matter of spinal cord +relationship: RO:0000052 UBERON:0002318 ! inheres in white matter of spinal cord [Term] id: OBA:0004278 @@ -139952,8 +239304,8 @@ def: "The amount of a Cajal-Retzius cell." [AUTO:patterns/patterns/entity_attrib synonym: "amount of Cajal-Retzius cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000695 ! Cajal-Retzius cell -relationship: inheres_in CL:0000695 ! Cajal-Retzius cell +intersection_of: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell +relationship: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell [Term] id: OBA:0004279 @@ -139963,8 +239315,8 @@ synonym: "rate of lipid catabolic process" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0016042 ! lipid catabolic process -relationship: inheres_in GO:0016042 ! lipid catabolic process +intersection_of: RO:0000052 GO:0016042 ! inheres in lipid catabolic process +relationship: RO:0000052 GO:0016042 ! inheres in lipid catabolic process [Term] id: OBA:0004280 @@ -139973,8 +239325,8 @@ def: "The morphology of a mature NK T cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of mature NK T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005717 ! alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000814 ! mature NK T cell -relationship: inheres_in CL:0000814 ! mature NK T cell +intersection_of: RO:0000052 CL:0000814 ! inheres in mature NK T cell +relationship: RO:0000052 CL:0000814 ! inheres in mature NK T cell [Term] id: OBA:0004281 @@ -139983,8 +239335,8 @@ def: "The amount of a mature NK T cell." [AUTO:patterns/patterns/entity_attribut synonym: "amount of mature NK T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005718 ! alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000814 ! mature NK T cell -relationship: inheres_in CL:0000814 ! mature NK T cell +intersection_of: RO:0000052 CL:0000814 ! inheres in mature NK T cell +relationship: RO:0000052 CL:0000814 ! inheres in mature NK T cell [Term] id: OBA:0004282 @@ -139993,8 +239345,8 @@ def: "The functionality of a mature NK T cell." [AUTO:patterns/patterns/entity_a synonym: "functionality of mature NK T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000814 ! mature NK T cell -relationship: inheres_in CL:0000814 ! mature NK T cell +intersection_of: RO:0000052 CL:0000814 ! inheres in mature NK T cell +relationship: RO:0000052 CL:0000814 ! inheres in mature NK T cell [Term] id: OBA:0004283 @@ -140003,8 +239355,8 @@ def: "The amount of a decidual natural killer cell, human." [AUTO:patterns/patte synonym: "amount of decidual natural killer cell, human" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005901 ! mature natural killer cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002343 ! decidual natural killer cell, human -relationship: inheres_in CL:0002343 ! decidual natural killer cell, human +intersection_of: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human +relationship: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human [Term] id: OBA:0004284 @@ -140013,8 +239365,8 @@ def: "The amount of a memory T cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of memory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000813 ! memory T cell -relationship: inheres_in CL:0000813 ! memory T cell +intersection_of: RO:0000052 CL:0000813 ! inheres in memory T cell +relationship: RO:0000052 CL:0000813 ! inheres in memory T cell [Term] id: OBA:0004285 @@ -140023,8 +239375,8 @@ def: "The morphology of a serous gland." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of serous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000409 ! serous gland -relationship: inheres_in UBERON:0000409 ! serous gland +intersection_of: RO:0000052 UBERON:0000409 ! inheres in serous gland +relationship: RO:0000052 UBERON:0000409 ! inheres in serous gland [Term] id: OBA:0004286 @@ -140033,8 +239385,8 @@ def: "The morphology of a decidual natural killer cell, human." [AUTO:patterns/p synonym: "morphology of decidual natural killer cell, human" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005905 ! mature natural killer cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002343 ! decidual natural killer cell, human -relationship: inheres_in CL:0002343 ! decidual natural killer cell, human +intersection_of: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human +relationship: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human [Term] id: OBA:0004287 @@ -140043,8 +239395,8 @@ def: "The morphology of a retinal ganglion cell." [AUTO:patterns/patterns/entity synonym: "morphology of retinal ganglion cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000740 ! retinal ganglion cell -relationship: inheres_in CL:0000740 ! retinal ganglion cell +intersection_of: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell +relationship: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell [Term] id: OBA:0004288 @@ -140054,8 +239406,8 @@ synonym: "morphology of podocyte foot" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0098846 ! podocyte foot -relationship: inheres_in GO:0098846 ! podocyte foot +intersection_of: RO:0000052 GO:0098846 ! inheres in podocyte foot +relationship: RO:0000052 GO:0098846 ! inheres in podocyte foot [Term] id: OBA:0004289 @@ -140065,8 +239417,8 @@ synonym: "morphology of podocyte slit diaphragm" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004032 ! podocyte slit diaphragm -relationship: inheres_in UBERON:0004032 ! podocyte slit diaphragm +intersection_of: RO:0000052 UBERON:0004032 ! inheres in podocyte slit diaphragm +relationship: RO:0000052 UBERON:0004032 ! inheres in podocyte slit diaphragm [Term] id: OBA:0004290 @@ -140076,8 +239428,8 @@ synonym: "amount of podocyte slit diaphragm" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004032 ! podocyte slit diaphragm -relationship: inheres_in UBERON:0004032 ! podocyte slit diaphragm +intersection_of: RO:0000052 UBERON:0004032 ! inheres in podocyte slit diaphragm +relationship: RO:0000052 UBERON:0004032 ! inheres in podocyte slit diaphragm [Term] id: OBA:0004291 @@ -140087,8 +239439,8 @@ synonym: "morphology of podocyte slit junction" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004033 ! podocyte slit junction -relationship: inheres_in UBERON:0004033 ! podocyte slit junction +intersection_of: RO:0000052 UBERON:0004033 ! inheres in podocyte slit junction +relationship: RO:0000052 UBERON:0004033 ! inheres in podocyte slit junction [Term] id: OBA:0004292 @@ -140098,7 +239450,7 @@ synonym: "shape of endolymphatic duct" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0006011 ! endolymphatic duct morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001860 ! endolymphatic duct +intersection_of: RO:0000052 UBERON:0001860 ! inheres in endolymphatic duct [Term] id: OBA:0004293 @@ -140108,7 +239460,7 @@ synonym: "degeneration of retinal ganglion cell" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003796 ! neuron degeneration is_a: OBA:0004287 ! retinal ganglion cell morphology intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000740 ! retinal ganglion cell +intersection_of: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell [Term] id: OBA:0004294 @@ -140117,8 +239469,8 @@ def: "The amount of a CD4-positive, alpha-beta T cell." [AUTO:patterns/patterns/ synonym: "amount of CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005718 ! alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000624 ! CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000624 ! inheres in CD4-positive, alpha-beta T cell [Term] id: OBA:0004295 @@ -140127,8 +239479,8 @@ def: "The amount of a CD8-positive, alpha-beta T cell." [AUTO:patterns/patterns/ synonym: "amount of CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005718 ! alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000625 ! CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000625 ! inheres in CD8-positive, alpha-beta T cell [Term] id: OBA:0004296 @@ -140137,8 +239489,8 @@ def: "The amount of a T-helper 1 cell." [AUTO:patterns/patterns/entity_attribute synonym: "amount of T-helper 1 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002637 ! CD4-positive helper T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000545 ! T-helper 1 cell -relationship: inheres_in CL:0000545 ! T-helper 1 cell +intersection_of: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell +relationship: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell [Term] id: OBA:0004297 @@ -140147,8 +239499,8 @@ def: "The amount of a T-helper 2 cell." [AUTO:patterns/patterns/entity_attribute synonym: "amount of T-helper 2 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002637 ! CD4-positive helper T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000546 ! T-helper 2 cell -relationship: inheres_in CL:0000546 ! T-helper 2 cell +intersection_of: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell +relationship: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell [Term] id: OBA:0004298 @@ -140157,8 +239509,8 @@ def: "The amount of a memory B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of memory B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000787 ! memory B cell -relationship: inheres_in CL:0000787 ! memory B cell +intersection_of: RO:0000052 CL:0000787 ! inheres in memory B cell +relationship: RO:0000052 CL:0000787 ! inheres in memory B cell [Term] id: OBA:0004299 @@ -140167,8 +239519,8 @@ def: "The amount of a plasma cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of plasma cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003352 ! lymphocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000786 ! plasma cell -relationship: inheres_in CL:0000786 ! plasma cell +intersection_of: RO:0000052 CL:0000786 ! inheres in plasma cell +relationship: RO:0000052 CL:0000786 ! inheres in plasma cell [Term] id: OBA:0004300 @@ -140178,7 +239530,7 @@ synonym: "degeneration of amacrine cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003796 ! neuron degeneration is_a: OBA:VT0005240 ! amacrine cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000561 ! amacrine cell +intersection_of: RO:0000052 CL:0000561 ! inheres in amacrine cell [Term] id: OBA:0004301 @@ -140188,8 +239540,8 @@ synonym: "amount of amacrine cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0001329 ! retina cell quantity is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000561 ! amacrine cell -relationship: inheres_in CL:0000561 ! amacrine cell +intersection_of: RO:0000052 CL:0000561 ! inheres in amacrine cell +relationship: RO:0000052 CL:0000561 ! inheres in amacrine cell [Term] id: OBA:0004302 @@ -140199,8 +239551,8 @@ synonym: "amount of retina horizontal cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0001329 ! retina cell quantity is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000745 ! retina horizontal cell -relationship: inheres_in CL:0000745 ! retina horizontal cell +intersection_of: RO:0000052 CL:0000745 ! inheres in retina horizontal cell +relationship: RO:0000052 CL:0000745 ! inheres in retina horizontal cell [Term] id: OBA:0004303 @@ -140211,8 +239563,8 @@ is_a: OBA:0004306 ! dendritic cell amount is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000453 ! Langerhans cell -relationship: inheres_in CL:0000453 ! Langerhans cell +intersection_of: RO:0000052 CL:0000453 ! inheres in Langerhans cell +relationship: RO:0000052 CL:0000453 ! inheres in Langerhans cell [Term] id: OBA:0004304 @@ -140223,8 +239575,8 @@ is_a: OBA:0004306 ! dendritic cell amount is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000782 ! myeloid dendritic cell -relationship: inheres_in CL:0000782 ! myeloid dendritic cell +intersection_of: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell +relationship: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell [Term] id: OBA:0004305 @@ -140233,8 +239585,8 @@ def: "The amount of a plasmacytoid dendritic cell." [AUTO:patterns/patterns/enti synonym: "amount of plasmacytoid dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004306 ! dendritic cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000784 ! plasmacytoid dendritic cell -relationship: inheres_in CL:0000784 ! plasmacytoid dendritic cell +intersection_of: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell +relationship: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell [Term] id: OBA:0004306 @@ -140243,8 +239595,8 @@ def: "The amount of a dendritic cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000451 ! dendritic cell -relationship: inheres_in CL:0000451 ! dendritic cell +intersection_of: RO:0000052 CL:0000451 ! inheres in dendritic cell +relationship: RO:0000052 CL:0000451 ! inheres in dendritic cell [Term] id: OBA:0004307 @@ -140253,8 +239605,8 @@ def: "The morphology of a internal capsule of telencephalon." [AUTO:patterns/pat synonym: "morphology of internal capsule of telencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004276 ! brain white matter morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001887 ! internal capsule of telencephalon -relationship: inheres_in UBERON:0001887 ! internal capsule of telencephalon +intersection_of: RO:0000052 UBERON:0001887 ! inheres in internal capsule of telencephalon +relationship: RO:0000052 UBERON:0001887 ! inheres in internal capsule of telencephalon [Term] id: OBA:0004308 @@ -140264,8 +239616,8 @@ synonym: "amount of internal capsule of telencephalon" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001887 ! internal capsule of telencephalon -relationship: inheres_in UBERON:0001887 ! internal capsule of telencephalon +intersection_of: RO:0000052 UBERON:0001887 ! inheres in internal capsule of telencephalon +relationship: RO:0000052 UBERON:0001887 ! inheres in internal capsule of telencephalon [Term] id: OBA:0004309 @@ -140275,8 +239627,8 @@ synonym: "morphology of pars intermedia of adenohypophysis" EXACT [AUTO:patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002432 ! pars intermedia of adenohypophysis -relationship: inheres_in UBERON:0002432 ! pars intermedia of adenohypophysis +intersection_of: RO:0000052 UBERON:0002432 ! inheres in pars intermedia of adenohypophysis +relationship: RO:0000052 UBERON:0002432 ! inheres in pars intermedia of adenohypophysis [Term] id: OBA:0004310 @@ -140286,18 +239638,18 @@ synonym: "amount of Peyer's patch" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001211 ! Peyer's patch -relationship: inheres_in UBERON:0001211 ! Peyer's patch +intersection_of: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch +relationship: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch [Term] id: OBA:0004311 -name: glomerular visceral epithelial cell amount -def: "The amount of a glomerular visceral epithelial cell." [AUTO:patterns/patterns/entity_attribute] -synonym: "amount of glomerular visceral epithelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000844 ! glomerular visceral epithelial cell quality +name: podocyte amount +def: "The amount of a podocyte." [AUTO:patterns/patterns/entity_attribute] +synonym: "amount of podocyte" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:1000844 ! podocyte quality is_a: OBA:VT0003446 ! kidney cell quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000653 ! glomerular visceral epithelial cell +intersection_of: RO:0000052 CL:0000653 ! inheres in podocyte [Term] id: OBA:0004312 @@ -140307,8 +239659,8 @@ synonym: "amount of podocyte foot" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0098846 ! podocyte foot -relationship: inheres_in GO:0098846 ! podocyte foot +intersection_of: RO:0000052 GO:0098846 ! inheres in podocyte foot +relationship: RO:0000052 GO:0098846 ! inheres in podocyte foot [Term] id: OBA:0004313 @@ -140317,8 +239669,8 @@ def: "The amount of a B-1a B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of B-1a B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004109 ! B-1 B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000820 ! B-1a B cell -relationship: inheres_in CL:0000820 ! B-1a B cell +intersection_of: RO:0000052 CL:0000820 ! inheres in B-1a B cell +relationship: RO:0000052 CL:0000820 ! inheres in B-1a B cell [Term] id: OBA:0004314 @@ -140327,8 +239679,8 @@ def: "The amount of a B-1b B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of B-1b B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004109 ! B-1 B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000821 ! B-1b B cell -relationship: inheres_in CL:0000821 ! B-1b B cell +intersection_of: RO:0000052 CL:0000821 ! inheres in B-1b B cell +relationship: RO:0000052 CL:0000821 ! inheres in B-1b B cell [Term] id: OBA:0004315 @@ -140337,8 +239689,8 @@ def: "The amount of a follicular B cell." [AUTO:patterns/patterns/entity_attribu synonym: "amount of follicular B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004323 ! B-2 B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000843 ! follicular B cell -relationship: inheres_in CL:0000843 ! follicular B cell +intersection_of: RO:0000052 CL:0000843 ! inheres in follicular B cell +relationship: RO:0000052 CL:0000843 ! inheres in follicular B cell [Term] id: OBA:0004316 @@ -140347,8 +239699,8 @@ def: "The amount of a germinal center B cell." [AUTO:patterns/patterns/entity_at synonym: "amount of germinal center B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000844 ! germinal center B cell -relationship: inheres_in CL:0000844 ! germinal center B cell +intersection_of: RO:0000052 CL:0000844 ! inheres in germinal center B cell +relationship: RO:0000052 CL:0000844 ! inheres in germinal center B cell [Term] id: OBA:0004317 @@ -140357,8 +239709,8 @@ def: "The amount of a marginal zone B cell of spleen." [AUTO:patterns/patterns/e synonym: "amount of marginal zone B cell of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000845 ! marginal zone B cell of spleen -relationship: inheres_in CL:0000845 ! marginal zone B cell of spleen +intersection_of: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen +relationship: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen [Term] id: OBA:0004318 @@ -140367,8 +239719,8 @@ def: "The amount of a naive B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of naive B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000788 ! naive B cell -relationship: inheres_in CL:0000788 ! naive B cell +intersection_of: RO:0000052 CL:0000788 ! inheres in naive B cell +relationship: RO:0000052 CL:0000788 ! inheres in naive B cell [Term] id: OBA:0004319 @@ -140377,8 +239729,8 @@ def: "The amount of a pro-B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000826 ! pro-B cell -relationship: inheres_in CL:0000826 ! pro-B cell +intersection_of: RO:0000052 CL:0000826 ! inheres in pro-B cell +relationship: RO:0000052 CL:0000826 ! inheres in pro-B cell [Term] id: OBA:0004320 @@ -140387,8 +239739,8 @@ def: "The amount of a transitional stage B cell." [AUTO:patterns/patterns/entity synonym: "amount of transitional stage B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002633 ! B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000818 ! transitional stage B cell -relationship: inheres_in CL:0000818 ! transitional stage B cell +intersection_of: RO:0000052 CL:0000818 ! inheres in transitional stage B cell +relationship: RO:0000052 CL:0000818 ! inheres in transitional stage B cell [Term] id: OBA:0004321 @@ -140397,8 +239749,8 @@ def: "The morphology of a professional antigen presenting cell." [AUTO:patterns/ synonym: "morphology of professional antigen presenting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008246 ! leukocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000145 ! professional antigen presenting cell -relationship: inheres_in CL:0000145 ! professional antigen presenting cell +intersection_of: RO:0000052 CL:0000145 ! inheres in professional antigen presenting cell +relationship: RO:0000052 CL:0000145 ! inheres in professional antigen presenting cell [Term] id: OBA:0004322 @@ -140408,8 +239760,8 @@ synonym: "amount of follicular dendritic cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000442 ! follicular dendritic cell -relationship: inheres_in CL:0000442 ! follicular dendritic cell +intersection_of: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell +relationship: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell [Term] id: OBA:0004323 @@ -140418,8 +239770,8 @@ def: "The amount of a B-2 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of B-2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000822 ! B-2 B cell -relationship: inheres_in CL:0000822 ! B-2 B cell +intersection_of: RO:0000052 CL:0000822 ! inheres in B-2 B cell +relationship: RO:0000052 CL:0000822 ! inheres in B-2 B cell [Term] id: OBA:0004324 @@ -140428,8 +239780,8 @@ def: "The amount of a mature B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of mature B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002633 ! B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000785 ! mature B cell -relationship: inheres_in CL:0000785 ! mature B cell +intersection_of: RO:0000052 CL:0000785 ! inheres in mature B cell +relationship: RO:0000052 CL:0000785 ! inheres in mature B cell [Term] id: OBA:0004325 @@ -140438,8 +239790,8 @@ def: "The amount of a immature B cell." [AUTO:patterns/patterns/entity_attribute synonym: "amount of immature B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002633 ! B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000816 ! immature B cell -relationship: inheres_in CL:0000816 ! immature B cell +intersection_of: RO:0000052 CL:0000816 ! inheres in immature B cell +relationship: RO:0000052 CL:0000816 ! inheres in immature B cell [Term] id: OBA:0004326 @@ -140448,8 +239800,8 @@ def: "The morphology of a dorsal telencephalic commissure." [AUTO:patterns/patte synonym: "morphology of dorsal telencephalic commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002199 ! brain commissure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005340 ! dorsal telencephalic commissure -relationship: inheres_in UBERON:0005340 ! dorsal telencephalic commissure +intersection_of: RO:0000052 UBERON:0005340 ! inheres in dorsal telencephalic commissure +relationship: RO:0000052 UBERON:0005340 ! inheres in dorsal telencephalic commissure [Term] id: OBA:0004327 @@ -140458,8 +239810,8 @@ def: "The morphology of a ventral commissure." [AUTO:patterns/patterns/entity_at synonym: "morphology of ventral commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002199 ! brain commissure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005341 ! ventral commissure -relationship: inheres_in UBERON:0005341 ! ventral commissure +intersection_of: RO:0000052 UBERON:0005341 ! inheres in ventral commissure +relationship: RO:0000052 UBERON:0005341 ! inheres in ventral commissure [Term] id: OBA:0004328 @@ -140468,8 +239820,8 @@ def: "The morphology of a hippocampal commissure." [AUTO:patterns/patterns/entit synonym: "morphology of hippocampal commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004326 ! dorsal telencephalic commissure morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000908 ! hippocampal commissure -relationship: inheres_in UBERON:0000908 ! hippocampal commissure +intersection_of: RO:0000052 UBERON:0000908 ! inheres in hippocampal commissure +relationship: RO:0000052 UBERON:0000908 ! inheres in hippocampal commissure [Term] id: OBA:0004329 @@ -140479,7 +239831,7 @@ synonym: "size of hippocampal commissure" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004328 ! hippocampal commissure morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000908 ! hippocampal commissure +intersection_of: RO:0000052 UBERON:0000908 ! inheres in hippocampal commissure [Term] id: OBA:0004330 @@ -140489,8 +239841,8 @@ synonym: "amount of hippocampal commissure" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000908 ! hippocampal commissure -relationship: inheres_in UBERON:0000908 ! hippocampal commissure +intersection_of: RO:0000052 UBERON:0000908 ! inheres in hippocampal commissure +relationship: RO:0000052 UBERON:0000908 ! inheres in hippocampal commissure [Term] id: OBA:0004331 @@ -140499,8 +239851,8 @@ def: "The morphology of a anterior commissure." [AUTO:patterns/patterns/entity_a synonym: "morphology of anterior commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004327 ! ventral commissure morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000935 ! anterior commissure -relationship: inheres_in UBERON:0000935 ! anterior commissure +intersection_of: RO:0000052 UBERON:0000935 ! inheres in anterior commissure +relationship: RO:0000052 UBERON:0000935 ! inheres in anterior commissure [Term] id: OBA:0004332 @@ -140510,7 +239862,7 @@ synonym: "size of anterior commissure" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0004331 ! anterior commissure morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000935 ! anterior commissure +intersection_of: RO:0000052 UBERON:0000935 ! inheres in anterior commissure [Term] id: OBA:0004333 @@ -140520,8 +239872,8 @@ synonym: "amount of anterior commissure" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000935 ! anterior commissure -relationship: inheres_in UBERON:0000935 ! anterior commissure +intersection_of: RO:0000052 UBERON:0000935 ! inheres in anterior commissure +relationship: RO:0000052 UBERON:0000935 ! inheres in anterior commissure [Term] id: OBA:0004334 @@ -140531,8 +239883,8 @@ synonym: "deviation (from_normal) of habenular commissure" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0001909 ! habenular commissure -relationship: inheres_in UBERON:0001909 ! habenular commissure +intersection_of: RO:0000052 UBERON:0001909 ! inheres in habenular commissure +relationship: RO:0000052 UBERON:0001909 ! inheres in habenular commissure [Term] id: OBA:0004335 @@ -140541,8 +239893,8 @@ def: "The morphology of a cingulum of brain." [AUTO:patterns/patterns/entity_att synonym: "morphology of cingulum of brain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003961 ! cingulum of brain -relationship: inheres_in UBERON:0003961 ! cingulum of brain +intersection_of: RO:0000052 UBERON:0003961 ! inheres in cingulum of brain +relationship: RO:0000052 UBERON:0003961 ! inheres in cingulum of brain [Term] id: OBA:0004336 @@ -140552,8 +239904,8 @@ synonym: "amount of marginal zone of spleen" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001251 ! marginal zone of spleen -relationship: inheres_in UBERON:0001251 ! marginal zone of spleen +intersection_of: RO:0000052 UBERON:0001251 ! inheres in marginal zone of spleen +relationship: RO:0000052 UBERON:0001251 ! inheres in marginal zone of spleen [Term] id: OBA:0004337 @@ -140562,8 +239914,8 @@ def: "The morphology of a macrophage derived foam cell." [AUTO:patterns/patterns synonym: "morphology of macrophage derived foam cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004871 ! foam cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000517 ! macrophage derived foam cell -relationship: inheres_in CL:0000517 ! macrophage derived foam cell +intersection_of: RO:0000052 CL:0000517 ! inheres in macrophage derived foam cell +relationship: RO:0000052 CL:0000517 ! inheres in macrophage derived foam cell [Term] id: OBA:0004338 @@ -140572,8 +239924,8 @@ def: "The morphology of a mononuclear cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of mononuclear cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008246 ! leukocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000842 ! mononuclear cell -relationship: inheres_in CL:0000842 ! mononuclear cell +intersection_of: RO:0000052 CL:0000842 ! inheres in mononuclear cell +relationship: RO:0000052 CL:0000842 ! inheres in mononuclear cell [Term] id: OBA:0004339 @@ -140584,7 +239936,7 @@ is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0008246 ! leukocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000766 ! myeloid leukocyte +intersection_of: RO:0000052 CL:0000766 ! inheres in myeloid leukocyte [Term] id: OBA:0004340 @@ -140594,8 +239946,8 @@ synonym: "morphology of myometrium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001296 ! myometrium -relationship: inheres_in UBERON:0001296 ! myometrium +intersection_of: RO:0000052 UBERON:0001296 ! inheres in myometrium +relationship: RO:0000052 UBERON:0001296 ! inheres in myometrium [Term] id: OBA:0004341 @@ -140605,7 +239957,7 @@ synonym: "size of myometrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004340 ! myometrium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001296 ! myometrium +intersection_of: RO:0000052 UBERON:0001296 ! inheres in myometrium [Term] id: OBA:0004342 @@ -140615,7 +239967,7 @@ synonym: "size of endometrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004083 ! endometrium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001295 ! endometrium +intersection_of: RO:0000052 UBERON:0001295 ! inheres in endometrium [Term] id: OBA:0004343 @@ -140625,7 +239977,7 @@ synonym: "occurrence of male meiotic nuclear division" EXACT [AUTO:patterns/patt is_a: OBA:1000734 ! male meiotic nuclear division quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0007140 ! male meiotic nuclear division +intersection_of: RO:0000052 GO:0007140 ! inheres in male meiotic nuclear division [Term] id: OBA:0004344 @@ -140635,8 +239987,8 @@ synonym: "morphology of hippocampal field" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003876 ! hippocampal field -relationship: inheres_in UBERON:0003876 ! hippocampal field +intersection_of: RO:0000052 UBERON:0003876 ! inheres in hippocampal field +relationship: RO:0000052 UBERON:0003876 ! inheres in hippocampal field [Term] id: OBA:0004345 @@ -140645,8 +239997,8 @@ def: "The morphology of a CA1 field of hippocampus." [AUTO:patterns/patterns/ent synonym: "morphology of CA1 field of hippocampus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004344 ! hippocampal field morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003881 ! CA1 field of hippocampus -relationship: inheres_in UBERON:0003881 ! CA1 field of hippocampus +intersection_of: RO:0000052 UBERON:0003881 ! inheres in CA1 field of hippocampus +relationship: RO:0000052 UBERON:0003881 ! inheres in CA1 field of hippocampus [Term] id: OBA:0004346 @@ -140655,8 +240007,8 @@ def: "The morphology of a CA2 field of hippocampus." [AUTO:patterns/patterns/ent synonym: "morphology of CA2 field of hippocampus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004344 ! hippocampal field morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003882 ! CA2 field of hippocampus -relationship: inheres_in UBERON:0003882 ! CA2 field of hippocampus +intersection_of: RO:0000052 UBERON:0003882 ! inheres in CA2 field of hippocampus +relationship: RO:0000052 UBERON:0003882 ! inheres in CA2 field of hippocampus [Term] id: OBA:0004347 @@ -140665,8 +240017,8 @@ def: "The morphology of a CA3 field of hippocampus." [AUTO:patterns/patterns/ent synonym: "morphology of CA3 field of hippocampus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004344 ! hippocampal field morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003883 ! CA3 field of hippocampus -relationship: inheres_in UBERON:0003883 ! CA3 field of hippocampus +intersection_of: RO:0000052 UBERON:0003883 ! inheres in CA3 field of hippocampus +relationship: RO:0000052 UBERON:0003883 ! inheres in CA3 field of hippocampus [Term] id: OBA:0004348 @@ -140675,8 +240027,8 @@ def: "The morphology of a CA4 field of hippocampus." [AUTO:patterns/patterns/ent synonym: "morphology of CA4 field of hippocampus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004344 ! hippocampal field morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003884 ! CA4 field of hippocampus -relationship: inheres_in UBERON:0003884 ! CA4 field of hippocampus +intersection_of: RO:0000052 UBERON:0003884 ! inheres in CA4 field of hippocampus +relationship: RO:0000052 UBERON:0003884 ! inheres in CA4 field of hippocampus [Term] id: OBA:0004349 @@ -140686,7 +240038,7 @@ synonym: "occurrence of ossification" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0000057 ! ossification trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0001503 ! ossification +intersection_of: RO:0000052 GO:0001503 ! inheres in ossification [Term] id: OBA:0004350 @@ -140696,7 +240048,7 @@ synonym: "amount of endochondral ossification" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000756 ! endochondral ossification quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001958 ! endochondral ossification +intersection_of: RO:0000052 GO:0001958 ! inheres in endochondral ossification [Term] id: OBA:0004351 @@ -140706,7 +240058,7 @@ synonym: "amount of intramembranous ossification" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000670 ! intramembranous ossification quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001957 ! intramembranous ossification +intersection_of: RO:0000052 GO:0001957 ! inheres in intramembranous ossification [Term] id: OBA:0004352 @@ -140716,7 +240068,7 @@ synonym: "occurrence of spermatid development" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0001932 ! spermiogenesis trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0007286 ! spermatid development +intersection_of: RO:0000052 GO:0007286 ! inheres in spermatid development [Term] id: OBA:0004353 @@ -140725,8 +240077,8 @@ def: "The morphology of a hippocampus molecular layer." [AUTO:patterns/patterns/ synonym: "morphology of hippocampus molecular layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000813 ! hippocampus layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005368 ! hippocampus molecular layer -relationship: inheres_in UBERON:0005368 ! hippocampus molecular layer +intersection_of: RO:0000052 UBERON:0005368 ! inheres in hippocampus molecular layer +relationship: RO:0000052 UBERON:0005368 ! inheres in hippocampus molecular layer [Term] id: OBA:0004354 @@ -140736,8 +240088,8 @@ synonym: "morphology of subiculum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002191 ! subiculum -relationship: inheres_in UBERON:0002191 ! subiculum +intersection_of: RO:0000052 UBERON:0002191 ! inheres in subiculum +relationship: RO:0000052 UBERON:0002191 ! inheres in subiculum [Term] id: OBA:0004355 @@ -140747,7 +240099,7 @@ synonym: "morphology of adrenal cortex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000330 ! adrenal cortex quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001235 ! adrenal cortex +intersection_of: RO:0000052 UBERON:0001235 ! inheres in adrenal cortex [Term] id: OBA:0004356 @@ -140757,7 +240109,7 @@ synonym: "amount of adrenal cortex" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000330 ! adrenal cortex quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001235 ! adrenal cortex +intersection_of: RO:0000052 UBERON:0001235 ! inheres in adrenal cortex [Term] id: OBA:0004357 @@ -140767,8 +240119,8 @@ synonym: "morphology of zona glomerulosa of adrenal gland" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002053 ! zona glomerulosa of adrenal gland -relationship: inheres_in UBERON:0002053 ! zona glomerulosa of adrenal gland +intersection_of: RO:0000052 UBERON:0002053 ! inheres in zona glomerulosa of adrenal gland +relationship: RO:0000052 UBERON:0002053 ! inheres in zona glomerulosa of adrenal gland [Term] id: OBA:0004358 @@ -140778,8 +240130,8 @@ synonym: "morphology of zona fasciculata of adrenal gland" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002054 ! zona fasciculata of adrenal gland -relationship: inheres_in UBERON:0002054 ! zona fasciculata of adrenal gland +intersection_of: RO:0000052 UBERON:0002054 ! inheres in zona fasciculata of adrenal gland +relationship: RO:0000052 UBERON:0002054 ! inheres in zona fasciculata of adrenal gland [Term] id: OBA:0004359 @@ -140789,8 +240141,8 @@ synonym: "morphology of zona reticularis of adrenal gland" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002055 ! zona reticularis of adrenal gland -relationship: inheres_in UBERON:0002055 ! zona reticularis of adrenal gland +intersection_of: RO:0000052 UBERON:0002055 ! inheres in zona reticularis of adrenal gland +relationship: RO:0000052 UBERON:0002055 ! inheres in zona reticularis of adrenal gland [Term] id: OBA:0004360 @@ -140800,8 +240152,8 @@ synonym: "morphology of adrenal gland X zone" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009024 ! adrenal gland X zone -relationship: inheres_in UBERON:0009024 ! adrenal gland X zone +intersection_of: RO:0000052 UBERON:0009024 ! inheres in adrenal gland X zone +relationship: RO:0000052 UBERON:0009024 ! inheres in adrenal gland X zone [Term] id: OBA:0004361 @@ -140811,7 +240163,7 @@ synonym: "size of type II cell of adrenal medulla" EXACT [AUTO:patterns/patterns is_a: OBA:0000055 ! cell size is_a: OBA:0003873 ! type II cell of adrenal medulla morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0002082 ! type II cell of adrenal medulla +intersection_of: RO:0000052 CL:0002082 ! inheres in type II cell of adrenal medulla [Term] id: OBA:0004362 @@ -140820,8 +240172,8 @@ def: "The functionality of a organ of Corti supporting cell." [AUTO:patterns/pat synonym: "functionality of organ of Corti supporting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002490 ! organ of Corti supporting cell -relationship: inheres_in CL:0002490 ! organ of Corti supporting cell +intersection_of: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell +relationship: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell [Term] id: OBA:0004363 @@ -140831,7 +240183,7 @@ synonym: "length of scala media" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001421 ! scala media size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002295 ! scala media +intersection_of: RO:0000052 UBERON:0002295 ! inheres in scala media [Term] id: OBA:0004364 @@ -140840,8 +240192,8 @@ def: "The morphology of a pterygopalatine ganglion." [AUTO:patterns/patterns/ent synonym: "morphology of pterygopalatine ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003962 ! pterygopalatine ganglion -relationship: inheres_in UBERON:0003962 ! pterygopalatine ganglion +intersection_of: RO:0000052 UBERON:0003962 ! inheres in pterygopalatine ganglion +relationship: RO:0000052 UBERON:0003962 ! inheres in pterygopalatine ganglion [Term] id: OBA:0004365 @@ -140851,8 +240203,8 @@ synonym: "morphology of otic ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait is_a: OBA:VT0001096 ! glossopharyngeal ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003963 ! otic ganglion -relationship: inheres_in UBERON:0003963 ! otic ganglion +intersection_of: RO:0000052 UBERON:0003963 ! inheres in otic ganglion +relationship: RO:0000052 UBERON:0003963 ! inheres in otic ganglion [Term] id: OBA:0004366 @@ -140862,8 +240214,8 @@ synonym: "morphology of splanchnic nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003715 ! splanchnic nerve -relationship: inheres_in UBERON:0003715 ! splanchnic nerve +intersection_of: RO:0000052 UBERON:0003715 ! inheres in splanchnic nerve +relationship: RO:0000052 UBERON:0003715 ! inheres in splanchnic nerve [Term] id: OBA:0004367 @@ -140873,8 +240225,8 @@ synonym: "morphology of sympathetic afferent fiber" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003965 ! sympathetic afferent fiber -relationship: inheres_in UBERON:0003965 ! sympathetic afferent fiber +intersection_of: RO:0000052 UBERON:0003965 ! inheres in sympathetic afferent fiber +relationship: RO:0000052 UBERON:0003965 ! inheres in sympathetic afferent fiber [Term] id: OBA:0004368 @@ -140884,7 +240236,7 @@ synonym: "amount of adenohypophysis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000303 ! adenohypophysis quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002196 ! adenohypophysis +intersection_of: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis [Term] id: OBA:0004369 @@ -140893,8 +240245,8 @@ def: "The morphology of a somatotropin secreting cell." [AUTO:patterns/patterns/ synonym: "morphology of somatotropin secreting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000295 ! somatotropin secreting cell -relationship: inheres_in CL:0000295 ! somatotropin secreting cell +intersection_of: RO:0000052 CL:0000295 ! inheres in somatotropin secreting cell +relationship: RO:0000052 CL:0000295 ! inheres in somatotropin secreting cell [Term] id: OBA:0004370 @@ -140903,8 +240255,8 @@ def: "The morphology of a prolactin secreting cell." [AUTO:patterns/patterns/ent synonym: "morphology of prolactin secreting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000439 ! prolactin secreting cell -relationship: inheres_in CL:0000439 ! prolactin secreting cell +intersection_of: RO:0000052 CL:0000439 ! inheres in prolactin secreting cell +relationship: RO:0000052 CL:0000439 ! inheres in prolactin secreting cell [Term] id: OBA:0004371 @@ -140913,8 +240265,8 @@ def: "The morphology of a melanocyte stimulating hormone secreting cell." [AUTO: synonym: "morphology of melanocyte stimulating hormone secreting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000440 ! melanocyte stimulating hormone secreting cell -relationship: inheres_in CL:0000440 ! melanocyte stimulating hormone secreting cell +intersection_of: RO:0000052 CL:0000440 ! inheres in melanocyte stimulating hormone secreting cell +relationship: RO:0000052 CL:0000440 ! inheres in melanocyte stimulating hormone secreting cell [Term] id: OBA:0004372 @@ -140922,9 +240274,10 @@ name: gonadtroph morphology def: "The morphology of a gonadtroph." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of gonadtroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005268 ! neuroendocrine cell morphology +is_a: OBA:VT0002181 ! brain cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000437 ! gonadtroph -relationship: inheres_in CL:0000437 ! gonadtroph +intersection_of: RO:0000052 CL:0000437 ! inheres in gonadtroph +relationship: RO:0000052 CL:0000437 ! inheres in gonadtroph [Term] id: OBA:0004373 @@ -140932,9 +240285,10 @@ name: thyrotroph morphology def: "The morphology of a thyrotroph." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of thyrotroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005268 ! neuroendocrine cell morphology +is_a: OBA:VT0002181 ! brain cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000476 ! thyrotroph -relationship: inheres_in CL:0000476 ! thyrotroph +intersection_of: RO:0000052 CL:0000476 ! inheres in thyrotroph +relationship: RO:0000052 CL:0000476 ! inheres in thyrotroph [Term] id: OBA:0004374 @@ -140943,8 +240297,8 @@ def: "The morphology of a adrenocorticotropic hormone secreting cell." [AUTO:pat synonym: "morphology of adrenocorticotropic hormone secreting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000467 ! adrenocorticotropic hormone secreting cell -relationship: inheres_in CL:0000467 ! adrenocorticotropic hormone secreting cell +intersection_of: RO:0000052 CL:0000467 ! inheres in adrenocorticotropic hormone secreting cell +relationship: RO:0000052 CL:0000467 ! inheres in adrenocorticotropic hormone secreting cell [Term] id: OBA:0004375 @@ -140954,8 +240308,8 @@ synonym: "amount of somatotropin secreting cell" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000295 ! somatotropin secreting cell -relationship: inheres_in CL:0000295 ! somatotropin secreting cell +intersection_of: RO:0000052 CL:0000295 ! inheres in somatotropin secreting cell +relationship: RO:0000052 CL:0000295 ! inheres in somatotropin secreting cell [Term] id: OBA:0004376 @@ -140965,8 +240319,8 @@ synonym: "amount of prolactin secreting cell" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000439 ! prolactin secreting cell -relationship: inheres_in CL:0000439 ! prolactin secreting cell +intersection_of: RO:0000052 CL:0000439 ! inheres in prolactin secreting cell +relationship: RO:0000052 CL:0000439 ! inheres in prolactin secreting cell [Term] id: OBA:0004377 @@ -140976,8 +240330,8 @@ synonym: "amount of gonadtroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000437 ! gonadtroph -relationship: inheres_in CL:0000437 ! gonadtroph +intersection_of: RO:0000052 CL:0000437 ! inheres in gonadtroph +relationship: RO:0000052 CL:0000437 ! inheres in gonadtroph [Term] id: OBA:0004378 @@ -140987,8 +240341,8 @@ synonym: "amount of thyrotroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000476 ! thyrotroph -relationship: inheres_in CL:0000476 ! thyrotroph +intersection_of: RO:0000052 CL:0000476 ! inheres in thyrotroph +relationship: RO:0000052 CL:0000476 ! inheres in thyrotroph [Term] id: OBA:0004379 @@ -140998,8 +240352,8 @@ synonym: "amount of adrenocorticotropic hormone secreting cell" EXACT [AUTO:patt is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000467 ! adrenocorticotropic hormone secreting cell -relationship: inheres_in CL:0000467 ! adrenocorticotropic hormone secreting cell +intersection_of: RO:0000052 CL:0000467 ! inheres in adrenocorticotropic hormone secreting cell +relationship: RO:0000052 CL:0000467 ! inheres in adrenocorticotropic hormone secreting cell [Term] id: OBA:0004380 @@ -141008,8 +240362,8 @@ def: "The amount of a gamma-delta T cell." [AUTO:patterns/patterns/entity_attrib synonym: "amount of gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000798 ! gamma-delta T cell -relationship: inheres_in CL:0000798 ! gamma-delta T cell +intersection_of: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell +relationship: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell [Term] id: OBA:0004381 @@ -141019,8 +240373,8 @@ synonym: "amount of gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/pat is_a: OBA:0004382 ! mature gamma-delta T cell amount is_a: OBA:0004525 ! intraepithelial lymphocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell [Term] id: OBA:0004382 @@ -141029,8 +240383,8 @@ def: "The amount of a mature gamma-delta T cell." [AUTO:patterns/patterns/entity synonym: "amount of mature gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004380 ! gamma-delta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000800 ! mature gamma-delta T cell -relationship: inheres_in CL:0000800 ! mature gamma-delta T cell +intersection_of: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell +relationship: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell [Term] id: OBA:0004383 @@ -141039,8 +240393,8 @@ def: "The amount of a CD4-negative CD8-negative gamma-delta intraepithelial T ce synonym: "amount of CD4-negative CD8-negative gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004381 ! gamma-delta intraepithelial T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000803 ! CD4-negative CD8-negative gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000803 ! CD4-negative CD8-negative gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000803 ! inheres in CD4-negative CD8-negative gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000803 ! inheres in CD4-negative CD8-negative gamma-delta intraepithelial T cell [Term] id: OBA:0004384 @@ -141049,8 +240403,8 @@ def: "The amount of a CD8-alpha alpha positive, gamma-delta intraepithelial T ce synonym: "amount of CD8-alpha alpha positive, gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004381 ! gamma-delta intraepithelial T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000802 ! inheres in CD8-alpha alpha positive, gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000802 ! inheres in CD8-alpha alpha positive, gamma-delta intraepithelial T cell [Term] id: OBA:0004385 @@ -141060,7 +240414,7 @@ synonym: "size of pars intermedia of adenohypophysis" EXACT [AUTO:patterns/patte is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004309 ! pars intermedia of adenohypophysis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002432 ! pars intermedia of adenohypophysis +intersection_of: RO:0000052 UBERON:0002432 ! inheres in pars intermedia of adenohypophysis [Term] id: OBA:0004386 @@ -141070,7 +240424,7 @@ synonym: "length of malleus bone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001465 ! malleus size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001689 ! malleus bone +intersection_of: RO:0000052 UBERON:0001689 ! inheres in malleus bone [Term] id: OBA:0004387 @@ -141080,8 +240434,8 @@ synonym: "morphology of manubrium of malleus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006722 ! manubrium of malleus -relationship: inheres_in UBERON:0006722 ! manubrium of malleus +intersection_of: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus +relationship: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus [Term] id: OBA:0004388 @@ -141091,7 +240445,7 @@ synonym: "height of manubrium of malleus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004389 ! manubrium of malleus size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0006722 ! manubrium of malleus +intersection_of: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus [Term] id: OBA:0004389 @@ -141101,7 +240455,7 @@ synonym: "size of manubrium of malleus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004387 ! manubrium of malleus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006722 ! manubrium of malleus +intersection_of: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus [Term] id: OBA:0004390 @@ -141111,8 +240465,8 @@ synonym: "amount of manubrium of malleus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006722 ! manubrium of malleus -relationship: inheres_in UBERON:0006722 ! manubrium of malleus +intersection_of: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus +relationship: RO:0000052 UBERON:0006722 ! inheres in manubrium of malleus [Term] id: OBA:0004391 @@ -141122,7 +240476,7 @@ synonym: "size of malleus processus brevis" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005036 ! malleus processus brevis morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005354 ! malleus processus brevis +intersection_of: RO:0000052 UBERON:0005354 ! inheres in malleus processus brevis [Term] id: OBA:0004392 @@ -141132,8 +240486,8 @@ synonym: "amount of malleus head" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005342 ! malleus head -relationship: inheres_in UBERON:0005342 ! malleus head +intersection_of: RO:0000052 UBERON:0005342 ! inheres in malleus head +relationship: RO:0000052 UBERON:0005342 ! inheres in malleus head [Term] id: OBA:0004393 @@ -141143,8 +240497,8 @@ synonym: "morphology of gonial bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003966 ! gonial bone -relationship: inheres_in UBERON:0003966 ! gonial bone +intersection_of: RO:0000052 UBERON:0003966 ! inheres in gonial bone +relationship: RO:0000052 UBERON:0003966 ! inheres in gonial bone [Term] id: OBA:0004394 @@ -141154,8 +240508,8 @@ synonym: "amount of gonial bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003966 ! gonial bone -relationship: inheres_in UBERON:0003966 ! gonial bone +intersection_of: RO:0000052 UBERON:0003966 ! inheres in gonial bone +relationship: RO:0000052 UBERON:0003966 ! inheres in gonial bone [Term] id: OBA:0004395 @@ -141165,7 +240519,7 @@ synonym: "size of gonial bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004393 ! gonial bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003966 ! gonial bone +intersection_of: RO:0000052 UBERON:0003966 ! inheres in gonial bone [Term] id: OBA:0004396 @@ -141175,8 +240529,8 @@ synonym: "amount of nasal capsule" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006332 ! nasal capsule -relationship: inheres_in UBERON:0006332 ! nasal capsule +intersection_of: RO:0000052 UBERON:0006332 ! inheres in nasal capsule +relationship: RO:0000052 UBERON:0006332 ! inheres in nasal capsule [Term] id: OBA:0004397 @@ -141186,8 +240540,8 @@ synonym: "amount of basisphenoid bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006428 ! basisphenoid bone -relationship: inheres_in UBERON:0006428 ! basisphenoid bone +intersection_of: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone +relationship: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone [Term] id: OBA:0004398 @@ -141197,8 +240551,8 @@ synonym: "amount of styloid process of temporal bone" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003960 ! styloid process of temporal bone -relationship: inheres_in UBERON:0003960 ! styloid process of temporal bone +intersection_of: RO:0000052 UBERON:0003960 ! inheres in styloid process of temporal bone +relationship: RO:0000052 UBERON:0003960 ! inheres in styloid process of temporal bone [Term] id: OBA:0004399 @@ -141207,8 +240561,8 @@ def: "The morphology of a primordial germ cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of primordial germ cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000670 ! primordial germ cell -relationship: inheres_in CL:0000670 ! primordial germ cell +intersection_of: RO:0000052 CL:0000670 ! inheres in primordial germ cell +relationship: RO:0000052 CL:0000670 ! inheres in primordial germ cell [Term] id: OBA:0004400 @@ -141218,8 +240572,8 @@ synonym: "amount of primordial germ cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000670 ! primordial germ cell -relationship: inheres_in CL:0000670 ! primordial germ cell +intersection_of: RO:0000052 CL:0000670 ! inheres in primordial germ cell +relationship: RO:0000052 CL:0000670 ! inheres in primordial germ cell [Term] id: OBA:0004401 @@ -141229,7 +240583,7 @@ synonym: "size of somatotropin secreting cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000055 ! cell size is_a: OBA:0004369 ! somatotropin secreting cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000295 ! somatotropin secreting cell +intersection_of: RO:0000052 CL:0000295 ! inheres in somatotropin secreting cell [Term] id: OBA:0004402 @@ -141238,8 +240592,8 @@ def: "The morphology of a cutaneous elastic tissue." [AUTO:patterns/patterns/ent synonym: "morphology of cutaneous elastic tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003967 ! cutaneous elastic tissue -relationship: inheres_in UBERON:0003967 ! cutaneous elastic tissue +intersection_of: RO:0000052 UBERON:0003967 ! inheres in cutaneous elastic tissue +relationship: RO:0000052 UBERON:0003967 ! inheres in cutaneous elastic tissue [Term] id: OBA:0004403 @@ -141249,8 +240603,8 @@ synonym: "morphology of cutaneous microfibril" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004034 ! cutaneous microfibril -relationship: inheres_in UBERON:0004034 ! cutaneous microfibril +intersection_of: RO:0000052 UBERON:0004034 ! inheres in cutaneous microfibril +relationship: RO:0000052 UBERON:0004034 ! inheres in cutaneous microfibril [Term] id: OBA:0004404 @@ -141260,7 +240614,7 @@ synonym: "size of thyrotroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:0004373 ! thyrotroph morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000476 ! thyrotroph +intersection_of: RO:0000052 CL:0000476 ! inheres in thyrotroph [Term] id: OBA:0004405 @@ -141270,7 +240624,7 @@ synonym: "size of prolactin secreting cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000055 ! cell size is_a: OBA:0004370 ! prolactin secreting cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000439 ! prolactin secreting cell +intersection_of: RO:0000052 CL:0000439 ! inheres in prolactin secreting cell [Term] id: OBA:0004406 @@ -141280,7 +240634,7 @@ synonym: "size of gonadtroph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:0004372 ! gonadtroph morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000437 ! gonadtroph +intersection_of: RO:0000052 CL:0000437 ! inheres in gonadtroph [Term] id: OBA:0004407 @@ -141290,7 +240644,7 @@ synonym: "size of adrenocorticotropic hormone secreting cell" EXACT [AUTO:patter is_a: OBA:0000055 ! cell size is_a: OBA:0004374 ! adrenocorticotropic hormone secreting cell morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000467 ! adrenocorticotropic hormone secreting cell +intersection_of: RO:0000052 CL:0000467 ! inheres in adrenocorticotropic hormone secreting cell [Term] id: OBA:0004408 @@ -141300,8 +240654,8 @@ synonym: "amount of parotid gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001831 ! parotid gland -relationship: inheres_in UBERON:0001831 ! parotid gland +intersection_of: RO:0000052 UBERON:0001831 ! inheres in parotid gland +relationship: RO:0000052 UBERON:0001831 ! inheres in parotid gland [Term] id: OBA:0004409 @@ -141312,7 +240666,7 @@ is_a: OBA:1000138 ! bone element size is_a: OBA:VT0004423 ! squama temporalis morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001695 ! squamous part of temporal bone +intersection_of: RO:0000052 UBERON:0001695 ! inheres in squamous part of temporal bone [Term] id: OBA:0004410 @@ -141322,8 +240676,8 @@ synonym: "morphology of cortical plate" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005343 ! cortical plate -relationship: inheres_in UBERON:0005343 ! cortical plate +intersection_of: RO:0000052 UBERON:0005343 ! inheres in cortical plate +relationship: RO:0000052 UBERON:0005343 ! inheres in cortical plate [Term] id: OBA:0004411 @@ -141333,8 +240687,8 @@ synonym: "morphology of cortical subplate" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004035 ! cortical subplate -relationship: inheres_in UBERON:0004035 ! cortical subplate +intersection_of: RO:0000052 UBERON:0004035 ! inheres in cortical subplate +relationship: RO:0000052 UBERON:0004035 ! inheres in cortical subplate [Term] id: OBA:0004412 @@ -141344,7 +240698,7 @@ synonym: "size of cortical plate" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004410 ! cortical plate morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005343 ! cortical plate +intersection_of: RO:0000052 UBERON:0005343 ! inheres in cortical plate [Term] id: OBA:0004413 @@ -141354,7 +240708,7 @@ synonym: "organization quality of cortical plate" EXACT [AUTO:patterns/patterns/ is_a: OBA:0004410 ! cortical plate morphology is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0005343 ! cortical plate +intersection_of: RO:0000052 UBERON:0005343 ! inheres in cortical plate [Term] id: OBA:0004414 @@ -141364,8 +240718,8 @@ synonym: "amount of cortical subplate" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004035 ! cortical subplate -relationship: inheres_in UBERON:0004035 ! cortical subplate +intersection_of: RO:0000052 UBERON:0004035 ! inheres in cortical subplate +relationship: RO:0000052 UBERON:0004035 ! inheres in cortical subplate [Term] id: OBA:0004415 @@ -141375,7 +240729,7 @@ synonym: "degeneration of retinal cone cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0004417 ! eye photoreceptor cell degeneration is_a: OBA:VT0001006 ! retinal cone cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000573 ! retinal cone cell +intersection_of: RO:0000052 CL:0000573 ! inheres in retinal cone cell [Term] id: OBA:0004416 @@ -141384,8 +240738,8 @@ def: "The amount of a retinal cone cell." [AUTO:patterns/patterns/entity_attribu synonym: "amount of retinal cone cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003637 ! eye photoreceptor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000573 ! retinal cone cell -relationship: inheres_in CL:0000573 ! retinal cone cell +intersection_of: RO:0000052 CL:0000573 ! inheres in retinal cone cell +relationship: RO:0000052 CL:0000573 ! inheres in retinal cone cell [Term] id: OBA:0004417 @@ -141395,7 +240749,7 @@ synonym: "degeneration of eye photoreceptor cell" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003590 ! eye photoreceptor cell morphology is_a: OBA:0003796 ! neuron degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000287 ! eye photoreceptor cell +intersection_of: RO:0000052 CL:0000287 ! inheres in eye photoreceptor cell [Term] id: OBA:0004418 @@ -141405,7 +240759,7 @@ synonym: "degeneration of retinal rod cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0004417 ! eye photoreceptor cell degeneration is_a: OBA:VT0001005 ! retinal rod cell morphology trait intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000604 ! retinal rod cell +intersection_of: RO:0000052 CL:0000604 ! inheres in retinal rod cell [Term] id: OBA:0004419 @@ -141414,8 +240768,8 @@ def: "The amount of a retinal rod cell." [AUTO:patterns/patterns/entity_attribut synonym: "amount of retinal rod cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003637 ! eye photoreceptor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000604 ! retinal rod cell -relationship: inheres_in CL:0000604 ! retinal rod cell +intersection_of: RO:0000052 CL:0000604 ! inheres in retinal rod cell +relationship: RO:0000052 CL:0000604 ! inheres in retinal rod cell [Term] id: OBA:0004420 @@ -141425,8 +240779,8 @@ synonym: "morphology of cortical intermediate zone" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004040 ! cortical intermediate zone -relationship: inheres_in UBERON:0004040 ! cortical intermediate zone +intersection_of: RO:0000052 UBERON:0004040 ! inheres in cortical intermediate zone +relationship: RO:0000052 UBERON:0004040 ! inheres in cortical intermediate zone [Term] id: OBA:0004421 @@ -141436,8 +240790,8 @@ synonym: "amount of dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000529 ! ganglion quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000044 ! dorsal root ganglion -relationship: inheres_in UBERON:0000044 ! dorsal root ganglion +intersection_of: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion +relationship: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion [Term] id: OBA:0004422 @@ -141447,7 +240801,7 @@ synonym: "symmetry of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0000020 ! left atrium morphology trait is_a: OBA:VT0006061 ! atrium symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:0004423 @@ -141456,8 +240810,8 @@ def: "The morphology of a medium spiny neuron." [AUTO:patterns/patterns/entity_a synonym: "morphology of medium spiny neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001474 ! medium spiny neuron -relationship: inheres_in CL:1001474 ! medium spiny neuron +intersection_of: RO:0000052 CL:1001474 ! inheres in medium spiny neuron +relationship: RO:0000052 CL:1001474 ! inheres in medium spiny neuron [Term] id: OBA:0004424 @@ -141466,8 +240820,8 @@ def: "The amount of a peripheral lymph node." [AUTO:patterns/patterns/entity_att synonym: "amount of peripheral lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003538 ! lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003968 ! peripheral lymph node -relationship: inheres_in UBERON:0003968 ! peripheral lymph node +intersection_of: RO:0000052 UBERON:0003968 ! inheres in peripheral lymph node +relationship: RO:0000052 UBERON:0003968 ! inheres in peripheral lymph node [Term] id: OBA:0004425 @@ -141476,8 +240830,8 @@ def: "The amount of a mesenteric lymph node." [AUTO:patterns/patterns/entity_att synonym: "amount of mesenteric lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003538 ! lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002509 ! mesenteric lymph node -relationship: inheres_in UBERON:0002509 ! mesenteric lymph node +intersection_of: RO:0000052 UBERON:0002509 ! inheres in mesenteric lymph node +relationship: RO:0000052 UBERON:0002509 ! inheres in mesenteric lymph node [Term] id: OBA:0004426 @@ -141486,8 +240840,8 @@ def: "The amount of a sensory neuron of dorsal root ganglion." [AUTO:patterns/pa synonym: "amount of sensory neuron of dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003577 ! sensory neuron amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1001451 ! sensory neuron of dorsal root ganglion -relationship: inheres_in CL:1001451 ! sensory neuron of dorsal root ganglion +intersection_of: RO:0000052 CL:1001451 ! inheres in sensory neuron of dorsal root ganglion +relationship: RO:0000052 CL:1001451 ! inheres in sensory neuron of dorsal root ganglion [Term] id: OBA:0004427 @@ -141497,8 +240851,8 @@ synonym: "deviation (from_normal) of spleen follicular dendritic cell network" E is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0010756 ! spleen follicular dendritic cell network -relationship: inheres_in UBERON:0010756 ! spleen follicular dendritic cell network +intersection_of: RO:0000052 UBERON:0010756 ! inheres in spleen follicular dendritic cell network +relationship: RO:0000052 UBERON:0010756 ! inheres in spleen follicular dendritic cell network [Term] id: OBA:0004428 @@ -141508,8 +240862,8 @@ synonym: "amount of red pulp of spleen" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001250 ! red pulp of spleen -relationship: inheres_in UBERON:0001250 ! red pulp of spleen +intersection_of: RO:0000052 UBERON:0001250 ! inheres in red pulp of spleen +relationship: RO:0000052 UBERON:0001250 ! inheres in red pulp of spleen [Term] id: OBA:0004429 @@ -141519,8 +240873,8 @@ synonym: "amount of white pulp of spleen" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001959 ! white pulp of spleen -relationship: inheres_in UBERON:0001959 ! white pulp of spleen +intersection_of: RO:0000052 UBERON:0001959 ! inheres in white pulp of spleen +relationship: RO:0000052 UBERON:0001959 ! inheres in white pulp of spleen [Term] id: OBA:0004430 @@ -141530,8 +240884,8 @@ synonym: "amount of muscle spindle" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003718 ! muscle spindle -relationship: inheres_in UBERON:0003718 ! muscle spindle +intersection_of: RO:0000052 UBERON:0003718 ! inheres in muscle spindle +relationship: RO:0000052 UBERON:0003718 ! inheres in muscle spindle [Term] id: OBA:0004431 @@ -141540,8 +240894,8 @@ def: "The morphology of a mesonephros." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of mesonephros" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002135 ! kidney morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000080 ! mesonephros -relationship: inheres_in UBERON:0000080 ! mesonephros +intersection_of: RO:0000052 UBERON:0000080 ! inheres in mesonephros +relationship: RO:0000052 UBERON:0000080 ! inheres in mesonephros [Term] id: OBA:0004432 @@ -141551,8 +240905,8 @@ synonym: "morphology of semicircular canal ampulla" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004043 ! semicircular canal ampulla -relationship: inheres_in UBERON:0004043 ! semicircular canal ampulla +intersection_of: RO:0000052 UBERON:0004043 ! inheres in semicircular canal ampulla +relationship: RO:0000052 UBERON:0004043 ! inheres in semicircular canal ampulla [Term] id: OBA:0004433 @@ -141562,7 +240916,7 @@ synonym: "degeneration of dorsal root ganglion" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0000961 ! dorsal root ganglion morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000044 ! dorsal root ganglion +intersection_of: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion [Term] id: OBA:0004434 @@ -141572,8 +240926,8 @@ synonym: "morphology of gray matter of spinal cord" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002315 ! gray matter of spinal cord -relationship: inheres_in UBERON:0002315 ! gray matter of spinal cord +intersection_of: RO:0000052 UBERON:0002315 ! inheres in gray matter of spinal cord +relationship: RO:0000052 UBERON:0002315 ! inheres in gray matter of spinal cord [Term] id: OBA:0004435 @@ -141582,8 +240936,8 @@ def: "The morphology of a type I cell of adrenal medulla." [AUTO:patterns/patter synonym: "morphology of type I cell of adrenal medulla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005268 ! neuroendocrine cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002083 ! type I cell of adrenal medulla -relationship: inheres_in CL:0002083 ! type I cell of adrenal medulla +intersection_of: RO:0000052 CL:0002083 ! inheres in type I cell of adrenal medulla +relationship: RO:0000052 CL:0002083 ! inheres in type I cell of adrenal medulla [Term] id: OBA:0004436 @@ -141593,7 +240947,7 @@ synonym: "size of ganglionic layer of retina" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0005241 ! retinal ganglion layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001792 ! ganglionic layer of retina +intersection_of: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina [Term] id: OBA:0004437 @@ -141603,7 +240957,7 @@ synonym: "organization quality of ganglionic layer of retina" EXACT [AUTO:patter is_a: OBA:VT0005241 ! retinal ganglion layer morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0001792 ! ganglionic layer of retina +intersection_of: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina [Term] id: OBA:0004438 @@ -141613,8 +240967,8 @@ synonym: "amount of ganglionic layer of retina" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001792 ! ganglionic layer of retina -relationship: inheres_in UBERON:0001792 ! ganglionic layer of retina +intersection_of: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina +relationship: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina [Term] id: OBA:0004439 @@ -141624,7 +240978,7 @@ synonym: "size of inner nuclear layer of retina" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0003733 ! retinal inner nuclear layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001791 ! inner nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001791 ! inheres in inner nuclear layer of retina [Term] id: OBA:0004440 @@ -141634,7 +240988,7 @@ synonym: "organization quality of inner nuclear layer of retina" EXACT [AUTO:pat is_a: OBA:VT0003733 ! retinal inner nuclear layer morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0001791 ! inner nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001791 ! inheres in inner nuclear layer of retina [Term] id: OBA:0004441 @@ -141644,7 +240998,7 @@ synonym: "size of inner plexiform layer of retina" EXACT [AUTO:patterns/patterns is_a: OBA:VT0003734 ! retinal inner plexiform layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001795 ! inner plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001795 ! inheres in inner plexiform layer of retina [Term] id: OBA:0004442 @@ -141654,8 +241008,8 @@ synonym: "amount of inner plexiform layer of retina" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001795 ! inner plexiform layer of retina -relationship: inheres_in UBERON:0001795 ! inner plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001795 ! inheres in inner plexiform layer of retina +relationship: RO:0000052 UBERON:0001795 ! inheres in inner plexiform layer of retina [Term] id: OBA:0004443 @@ -141665,7 +241019,7 @@ synonym: "size of outer nuclear layer of retina" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0003731 ! retinal outer nuclear layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001789 ! outer nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001789 ! inheres in outer nuclear layer of retina [Term] id: OBA:0004444 @@ -141675,7 +241029,7 @@ synonym: "organization quality of outer nuclear layer of retina" EXACT [AUTO:pat is_a: OBA:VT0003731 ! retinal outer nuclear layer morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0001789 ! outer nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001789 ! inheres in outer nuclear layer of retina [Term] id: OBA:0004445 @@ -141685,7 +241039,7 @@ synonym: "degeneration of outer nuclear layer of retina" EXACT [AUTO:patterns/pa is_a: OBA:VT0003731 ! retinal outer nuclear layer morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001789 ! outer nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001789 ! inheres in outer nuclear layer of retina [Term] id: OBA:0004446 @@ -141695,7 +241049,7 @@ synonym: "size of outer plexiform layer of retina" EXACT [AUTO:patterns/patterns is_a: OBA:VT0003732 ! retinal outer plexiform layer morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001790 ! outer plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001790 ! inheres in outer plexiform layer of retina [Term] id: OBA:0004447 @@ -141705,7 +241059,7 @@ synonym: "organization quality of outer plexiform layer of retina" EXACT [AUTO:p is_a: OBA:VT0003732 ! retinal outer plexiform layer morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0001790 ! outer plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001790 ! inheres in outer plexiform layer of retina [Term] id: OBA:0004448 @@ -141715,7 +241069,7 @@ synonym: "height of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010613 ! cranium size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:0004449 @@ -141724,8 +241078,8 @@ def: "The morphology of a anterior visceral endoderm." [AUTO:patterns/patterns/e synonym: "morphology of anterior visceral endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001724 ! extraembryonic endoderm morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004044 ! anterior visceral endoderm -relationship: inheres_in UBERON:0004044 ! anterior visceral endoderm +intersection_of: RO:0000052 UBERON:0004044 ! inheres in anterior visceral endoderm +relationship: RO:0000052 UBERON:0004044 ! inheres in anterior visceral endoderm [Term] id: OBA:0004450 @@ -141735,8 +241089,8 @@ synonym: "morphology of cerebral hemisphere" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001869 ! cerebral hemisphere -relationship: inheres_in UBERON:0001869 ! cerebral hemisphere +intersection_of: RO:0000052 UBERON:0001869 ! inheres in cerebral hemisphere +relationship: RO:0000052 UBERON:0001869 ! inheres in cerebral hemisphere [Term] id: OBA:0004451 @@ -141746,7 +241100,7 @@ synonym: "rate of sensory perception of smell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0001984 ! olfaction trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007608 ! sensory perception of smell +intersection_of: RO:0000052 GO:0007608 ! inheres in sensory perception of smell [Term] id: OBA:0004452 @@ -141756,8 +241110,8 @@ synonym: "amount of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0036126 ! sperm flagellum -relationship: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum +relationship: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004453 @@ -141767,7 +241121,7 @@ synonym: "rate of interferon-alpha production" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0008557 ! interferon-alpha secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032607 ! interferon-alpha production +intersection_of: RO:0000052 GO:0032607 ! inheres in interferon-alpha production [Term] id: OBA:0004454 @@ -141777,7 +241131,7 @@ synonym: "rate of interferon-beta production" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0008558 ! interferon-beta secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032608 ! interferon-beta production +intersection_of: RO:0000052 GO:0032608 ! inheres in interferon-beta production [Term] id: OBA:0004455 @@ -141787,7 +241141,7 @@ synonym: "rate of interferon-gamma production" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0008559 ! interferon-gamma secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032609 ! interferon-gamma production +intersection_of: RO:0000052 GO:0032609 ! inheres in interferon-gamma production [Term] id: OBA:0004456 @@ -141797,8 +241151,8 @@ synonym: "morphology of terminal bouton" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0043195 ! terminal bouton -relationship: inheres_in GO:0043195 ! terminal bouton +intersection_of: RO:0000052 GO:0043195 ! inheres in terminal bouton +relationship: RO:0000052 GO:0043195 ! inheres in terminal bouton [Term] id: OBA:0004457 @@ -141808,7 +241162,7 @@ synonym: "degeneration of photoreceptor inner segment" EXACT [AUTO:patterns/patt is_a: OBA:VT0003730 ! photoreceptor inner segment morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:0004458 @@ -141818,7 +241172,7 @@ synonym: "organization quality of photoreceptor inner segment" EXACT [AUTO:patte is_a: OBA:VT0003730 ! photoreceptor inner segment morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:0004459 @@ -141829,7 +241183,7 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:VT0003730 ! photoreceptor inner segment morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:0004460 @@ -141839,7 +241193,7 @@ synonym: "amount of photoreceptor inner segment" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000917 ! photoreceptor inner segment quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:0004461 @@ -141849,7 +241203,7 @@ synonym: "degeneration of photoreceptor outer segment" EXACT [AUTO:patterns/patt is_a: OBA:VT0003729 ! photoreceptor outer segment morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:0004462 @@ -141859,7 +241213,7 @@ synonym: "amount of photoreceptor outer segment" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000763 ! photoreceptor outer segment quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:0004463 @@ -141869,7 +241223,7 @@ synonym: "organization quality of photoreceptor outer segment" EXACT [AUTO:patte is_a: OBA:VT0003729 ! photoreceptor outer segment morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:0004464 @@ -141880,7 +241234,7 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:VT0003729 ! photoreceptor outer segment morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:0004465 @@ -141890,7 +241244,7 @@ synonym: "rate of interleukin-1 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008650 ! interleukin-1 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032612 ! interleukin-1 production +intersection_of: RO:0000052 GO:0032612 ! inheres in interleukin-1 production [Term] id: OBA:0004466 @@ -141900,7 +241254,7 @@ synonym: "rate of interleukin-1 alpha production" EXACT [AUTO:patterns/patterns/ is_a: OBA:0004465 ! interleukin-1 production rate is_a: OBA:VT0008653 ! interleukin-1 alpha secretion trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032610 ! interleukin-1 alpha production +intersection_of: RO:0000052 GO:0032610 ! inheres in interleukin-1 alpha production [Term] id: OBA:0004467 @@ -141910,7 +241264,7 @@ synonym: "rate of interleukin-1 beta production" EXACT [AUTO:patterns/patterns/e is_a: OBA:0004465 ! interleukin-1 production rate is_a: OBA:VT0008656 ! interleukin-1 beta secretion trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032611 ! interleukin-1 beta production +intersection_of: RO:0000052 GO:0032611 ! inheres in interleukin-1 beta production [Term] id: OBA:0004468 @@ -141920,7 +241274,7 @@ synonym: "rate of interleukin-10 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008659 ! interleukin-10 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032613 ! interleukin-10 production +intersection_of: RO:0000052 GO:0032613 ! inheres in interleukin-10 production [Term] id: OBA:0004469 @@ -141930,7 +241284,7 @@ synonym: "rate of interleukin-12 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008662 ! interleukin-12 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032615 ! interleukin-12 production +intersection_of: RO:0000052 GO:0032615 ! inheres in interleukin-12 production [Term] id: OBA:0004470 @@ -141940,7 +241294,7 @@ synonym: "rate of interleukin-13 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008671 ! interleukin-13 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032616 ! interleukin-13 production +intersection_of: RO:0000052 GO:0032616 ! inheres in interleukin-13 production [Term] id: OBA:0004471 @@ -141950,7 +241304,7 @@ synonym: "rate of interleukin-15 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008674 ! interleukin-15 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032618 ! interleukin-15 production +intersection_of: RO:0000052 GO:0032618 ! inheres in interleukin-15 production [Term] id: OBA:0004472 @@ -141960,7 +241314,7 @@ synonym: "rate of interleukin-16 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008677 ! interleukin-16 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032619 ! interleukin-16 production +intersection_of: RO:0000052 GO:0032619 ! inheres in interleukin-16 production [Term] id: OBA:0004473 @@ -141970,7 +241324,7 @@ synonym: "rate of interleukin-17 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008680 ! interleukin-17 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032620 ! interleukin-17 production +intersection_of: RO:0000052 GO:0032620 ! inheres in interleukin-17 production [Term] id: OBA:0004474 @@ -141980,7 +241334,7 @@ synonym: "rate of interleukin-18 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008683 ! interleukin-18 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032621 ! interleukin-18 production +intersection_of: RO:0000052 GO:0032621 ! inheres in interleukin-18 production [Term] id: OBA:0004475 @@ -141990,7 +241344,7 @@ synonym: "rate of interleukin-2 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008686 ! interleukin-2 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032623 ! interleukin-2 production +intersection_of: RO:0000052 GO:0032623 ! inheres in interleukin-2 production [Term] id: OBA:0004476 @@ -142000,7 +241354,7 @@ synonym: "rate of interleukin-23 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0008689 ! interleukin-23 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032627 ! interleukin-23 production +intersection_of: RO:0000052 GO:0032627 ! inheres in interleukin-23 production [Term] id: OBA:0004477 @@ -142010,7 +241364,7 @@ synonym: "rate of interleukin-3 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008695 ! interleukin-3 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032632 ! interleukin-3 production +intersection_of: RO:0000052 GO:0032632 ! inheres in interleukin-3 production [Term] id: OBA:0004478 @@ -142020,7 +241374,7 @@ synonym: "rate of interleukin-4 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008698 ! interleukin-4 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032633 ! interleukin-4 production +intersection_of: RO:0000052 GO:0032633 ! inheres in interleukin-4 production [Term] id: OBA:0004479 @@ -142030,7 +241384,7 @@ synonym: "rate of interleukin-5 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008701 ! interleukin-5 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032634 ! interleukin-5 production +intersection_of: RO:0000052 GO:0032634 ! inheres in interleukin-5 production [Term] id: OBA:0004480 @@ -142040,7 +241394,7 @@ synonym: "rate of interleukin-6 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008704 ! interleukin-6 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032635 ! interleukin-6 production +intersection_of: RO:0000052 GO:0032635 ! inheres in interleukin-6 production [Term] id: OBA:0004481 @@ -142050,7 +241404,7 @@ synonym: "rate of interleukin-7 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008707 ! interleukin-7 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032636 ! interleukin-7 production +intersection_of: RO:0000052 GO:0032636 ! inheres in interleukin-7 production [Term] id: OBA:0004482 @@ -142060,7 +241414,7 @@ synonym: "rate of interleukin-9 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0008710 ! interleukin-9 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032638 ! interleukin-9 production +intersection_of: RO:0000052 GO:0032638 ! inheres in interleukin-9 production [Term] id: OBA:0004483 @@ -142070,8 +241424,8 @@ synonym: "rate of neutrophil chemotaxis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005567 ! cell chemotaxis rate is_a: OBA:VT0003156 ! leukocyte migration trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0030593 ! neutrophil chemotaxis -relationship: inheres_in GO:0030593 ! neutrophil chemotaxis +intersection_of: RO:0000052 GO:0030593 ! inheres in neutrophil chemotaxis +relationship: RO:0000052 GO:0030593 ! inheres in neutrophil chemotaxis [Term] id: OBA:0004484 @@ -142081,8 +241435,8 @@ synonym: "rate of eosinophil chemotaxis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005567 ! cell chemotaxis rate is_a: OBA:VT0008724 ! eosinophil migration trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048245 ! eosinophil chemotaxis -relationship: inheres_in GO:0048245 ! eosinophil chemotaxis +intersection_of: RO:0000052 GO:0048245 ! inheres in eosinophil chemotaxis +relationship: RO:0000052 GO:0048245 ! inheres in eosinophil chemotaxis [Term] id: OBA:0004485 @@ -142092,7 +241446,7 @@ synonym: "position of T cell anergy" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0008747 ! T cell anergy trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in GO:0002870 ! T cell anergy +intersection_of: RO:0000052 GO:0002870 ! inheres in T cell anergy [Term] id: OBA:0004486 @@ -142102,7 +241456,7 @@ synonym: "viability of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000069 ! embryo trait is_a: PATO:0000169 ! viability intersection_of: PATO:0000169 ! viability -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:0004487 @@ -142112,8 +241466,8 @@ synonym: "amount of mast cell degranulation" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0043303 ! mast cell degranulation -relationship: inheres_in GO:0043303 ! mast cell degranulation +intersection_of: RO:0000052 GO:0043303 ! inheres in mast cell degranulation +relationship: RO:0000052 GO:0043303 ! inheres in mast cell degranulation [Term] id: OBA:0004488 @@ -142123,7 +241477,7 @@ synonym: "shape of vertebral column" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0010086 ! vertebral column morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column [Term] id: OBA:0004489 @@ -142133,8 +241487,8 @@ synonym: "pressure of cardiac ventricle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001025 ! pressure intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0002082 ! cardiac ventricle -relationship: inheres_in UBERON:0002082 ! cardiac ventricle +intersection_of: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle +relationship: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle [Term] id: OBA:0004490 @@ -142144,8 +241498,8 @@ synonym: "morphology of manubrium of sternum" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002205 ! manubrium of sternum -relationship: inheres_in UBERON:0002205 ! manubrium of sternum +intersection_of: RO:0000052 UBERON:0002205 ! inheres in manubrium of sternum +relationship: RO:0000052 UBERON:0002205 ! inheres in manubrium of sternum [Term] id: OBA:0004491 @@ -142155,8 +241509,8 @@ synonym: "morphology of hindgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001046 ! hindgut -relationship: inheres_in UBERON:0001046 ! hindgut +intersection_of: RO:0000052 UBERON:0001046 ! inheres in hindgut +relationship: RO:0000052 UBERON:0001046 ! inheres in hindgut [Term] id: OBA:0004492 @@ -142166,8 +241520,8 @@ synonym: "morphology of tailgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004045 ! tailgut -relationship: inheres_in UBERON:0004045 ! tailgut +intersection_of: RO:0000052 UBERON:0004045 ! inheres in tailgut +relationship: RO:0000052 UBERON:0004045 ! inheres in tailgut [Term] id: OBA:0004493 @@ -142176,8 +241530,8 @@ def: "The morphology of a fetal cardiomyocyte." [AUTO:patterns/patterns/entity_a synonym: "morphology of fetal cardiomyocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000061 ! cardiomyocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002495 ! fetal cardiomyocyte -relationship: inheres_in CL:0002495 ! fetal cardiomyocyte +intersection_of: RO:0000052 CL:0002495 ! inheres in fetal cardiomyocyte +relationship: RO:0000052 CL:0002495 ! inheres in fetal cardiomyocyte [Term] id: OBA:0004494 @@ -142187,8 +241541,8 @@ synonym: "amount of natural killer cell degranulation" EXACT [AUTO:patterns/patt is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0043320 ! natural killer cell degranulation -relationship: inheres_in GO:0043320 ! natural killer cell degranulation +intersection_of: RO:0000052 GO:0043320 ! inheres in natural killer cell degranulation +relationship: RO:0000052 GO:0043320 ! inheres in natural killer cell degranulation [Term] id: OBA:0004495 @@ -142198,8 +241552,8 @@ synonym: "morphology of erythroid progenitor cell" EXACT [AUTO:patterns/patterns is_a: OBA:0005897 ! erythroid lineage cell morphology is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000038 ! erythroid progenitor cell -relationship: inheres_in CL:0000038 ! erythroid progenitor cell +intersection_of: RO:0000052 CL:0000038 ! inheres in erythroid progenitor cell +relationship: RO:0000052 CL:0000038 ! inheres in erythroid progenitor cell [Term] id: OBA:0004496 @@ -142208,8 +241562,8 @@ def: "The morphology of a intestine smooth muscle." [AUTO:patterns/patterns/enti synonym: "morphology of intestine smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004221 ! intestine smooth muscle -relationship: inheres_in UBERON:0004221 ! intestine smooth muscle +intersection_of: RO:0000052 UBERON:0004221 ! inheres in intestine smooth muscle +relationship: RO:0000052 UBERON:0004221 ! inheres in intestine smooth muscle [Term] id: OBA:0004497 @@ -142219,7 +241573,7 @@ synonym: "structure of placental labyrinth vasculature" EXACT [AUTO:patterns/pat is_a: OBA:VT0003231 ! placenta vascular morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003970 ! placental labyrinth vasculature +intersection_of: RO:0000052 UBERON:0003970 ! inheres in placental labyrinth vasculature [Term] id: OBA:0004498 @@ -142228,8 +241582,8 @@ def: "The amount of a common myeloid progenitor." [AUTO:patterns/patterns/entity synonym: "amount of common myeloid progenitor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000049 ! common myeloid progenitor -relationship: inheres_in CL:0000049 ! common myeloid progenitor +intersection_of: RO:0000052 CL:0000049 ! inheres in common myeloid progenitor +relationship: RO:0000052 CL:0000049 ! inheres in common myeloid progenitor [Term] id: OBA:0004499 @@ -142239,8 +241593,8 @@ synonym: "structure of interfrontal bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003971 ! interfrontal bone -relationship: inheres_in UBERON:0003971 ! interfrontal bone +intersection_of: RO:0000052 UBERON:0003971 ! inheres in interfrontal bone +relationship: RO:0000052 UBERON:0003971 ! inheres in interfrontal bone [Term] id: OBA:0004500 @@ -142250,8 +241604,8 @@ synonym: "amount of interventricular septum membranous part" EXACT [AUTO:pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004666 ! interventricular septum membranous part -relationship: inheres_in UBERON:0004666 ! interventricular septum membranous part +intersection_of: RO:0000052 UBERON:0004666 ! inheres in interventricular septum membranous part +relationship: RO:0000052 UBERON:0004666 ! inheres in interventricular septum membranous part [Term] id: OBA:0004501 @@ -142261,8 +241615,8 @@ synonym: "morphology of nucleolus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005730 ! nucleolus -relationship: inheres_in GO:0005730 ! nucleolus +intersection_of: RO:0000052 GO:0005730 ! inheres in nucleolus +relationship: RO:0000052 GO:0005730 ! inheres in nucleolus [Term] id: OBA:0004502 @@ -142272,8 +241626,8 @@ synonym: "amount of acrosomal vesicle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001669 ! acrosomal vesicle -relationship: inheres_in GO:0001669 ! acrosomal vesicle +intersection_of: RO:0000052 GO:0001669 ! inheres in acrosomal vesicle +relationship: RO:0000052 GO:0001669 ! inheres in acrosomal vesicle [Term] id: OBA:0004503 @@ -142283,7 +241637,7 @@ synonym: "wholeness of capsule of lens" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0003236 ! lens capsule morphology trait is_a: PATO:0001442 ! wholeness intersection_of: PATO:0001442 ! wholeness -intersection_of: inheres_in UBERON:0001804 ! capsule of lens +intersection_of: RO:0000052 UBERON:0001804 ! inheres in capsule of lens [Term] id: OBA:0004504 @@ -142293,7 +241647,7 @@ synonym: "amount of subcutaneous adipose tissue" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000023 ! subcutaneous adipose tissue quality is_a: OBA:VT0005452 ! adipose amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue [Term] id: OBA:0004505 @@ -142303,8 +241657,8 @@ synonym: "morphology of paraventricular nucleus of hypothalamus" EXACT [AUTO:pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001930 ! paraventricular nucleus of hypothalamus -relationship: inheres_in UBERON:0001930 ! paraventricular nucleus of hypothalamus +intersection_of: RO:0000052 UBERON:0001930 ! inheres in paraventricular nucleus of hypothalamus +relationship: RO:0000052 UBERON:0001930 ! inheres in paraventricular nucleus of hypothalamus [Term] id: OBA:0004506 @@ -142314,8 +241668,8 @@ synonym: "morphology of supraoptic nucleus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001929 ! supraoptic nucleus -relationship: inheres_in UBERON:0001929 ! supraoptic nucleus +intersection_of: RO:0000052 UBERON:0001929 ! inheres in supraoptic nucleus +relationship: RO:0000052 UBERON:0001929 ! inheres in supraoptic nucleus [Term] id: OBA:0004507 @@ -142325,8 +241679,8 @@ synonym: "morphology of suprachiasmatic nucleus" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002034 ! suprachiasmatic nucleus -relationship: inheres_in UBERON:0002034 ! suprachiasmatic nucleus +intersection_of: RO:0000052 UBERON:0002034 ! inheres in suprachiasmatic nucleus +relationship: RO:0000052 UBERON:0002034 ! inheres in suprachiasmatic nucleus [Term] id: OBA:0004508 @@ -142336,8 +241690,8 @@ synonym: "morphology of anterior nucleus of hypothalamus" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002634 ! anterior nucleus of hypothalamus -relationship: inheres_in UBERON:0002634 ! anterior nucleus of hypothalamus +intersection_of: RO:0000052 UBERON:0002634 ! inheres in anterior nucleus of hypothalamus +relationship: RO:0000052 UBERON:0002634 ! inheres in anterior nucleus of hypothalamus [Term] id: OBA:0004509 @@ -142347,7 +241701,7 @@ synonym: "phase of catagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000721 ! catagen quality is_a: PATO:0000083 ! phase intersection_of: PATO:0000083 ! phase -intersection_of: inheres_in GO:0042637 ! catagen +intersection_of: RO:0000052 GO:0042637 ! inheres in catagen [Term] id: OBA:0004510 @@ -142357,8 +241711,8 @@ synonym: "phase of telogen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000083 ! phase intersection_of: PATO:0000083 ! phase -intersection_of: inheres_in GO:0042639 ! telogen -relationship: inheres_in GO:0042639 ! telogen +intersection_of: RO:0000052 GO:0042639 ! inheres in telogen +relationship: RO:0000052 GO:0042639 ! inheres in telogen [Term] id: OBA:0004511 @@ -142368,7 +241722,7 @@ synonym: "symmetry of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003499 ! midface morphology is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:0004512 @@ -142378,7 +241732,7 @@ synonym: "symmetry of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000432 ! head morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:0004513 @@ -142387,8 +241741,8 @@ def: "The morphology of a granulosa cell." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of granulosa cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000501 ! granulosa cell -relationship: inheres_in CL:0000501 ! granulosa cell +intersection_of: RO:0000052 CL:0000501 ! inheres in granulosa cell +relationship: RO:0000052 CL:0000501 ! inheres in granulosa cell [Term] id: OBA:0004514 @@ -142398,7 +241752,7 @@ synonym: "amount of ovulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001928 ! ovulation trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0030728 ! ovulation +intersection_of: RO:0000052 GO:0030728 ! inheres in ovulation [Term] id: OBA:0004515 @@ -142408,7 +241762,7 @@ synonym: "altered number of of mature ovarian follicle" EXACT [AUTO:patterns/pat is_a: OBA:0004697 ! mature ovarian follicle morphology is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0003982 ! mature ovarian follicle +intersection_of: RO:0000052 UBERON:0003982 ! inheres in mature ovarian follicle [Term] id: OBA:0004516 @@ -142418,7 +241772,7 @@ synonym: "amount of ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000927 ! ovarian follicle quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001305 ! ovarian follicle +intersection_of: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle [Term] id: OBA:0004517 @@ -142428,8 +241782,8 @@ synonym: "amount of Harderian gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004187 ! Harderian gland -relationship: inheres_in UBERON:0004187 ! Harderian gland +intersection_of: RO:0000052 UBERON:0004187 ! inheres in Harderian gland +relationship: RO:0000052 UBERON:0004187 ! inheres in Harderian gland [Term] id: OBA:0004518 @@ -142438,8 +241792,8 @@ def: "The functionality of a enterocyte." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of enterocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000584 ! enterocyte -relationship: inheres_in CL:0000584 ! enterocyte +intersection_of: RO:0000052 CL:0000584 ! inheres in enterocyte +relationship: RO:0000052 CL:0000584 ! inheres in enterocyte [Term] id: OBA:0004519 @@ -142449,8 +241803,8 @@ synonym: "morphology of PML body" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0016605 ! PML body -relationship: inheres_in GO:0016605 ! PML body +intersection_of: RO:0000052 GO:0016605 ! inheres in PML body +relationship: RO:0000052 GO:0016605 ! inheres in PML body [Term] id: OBA:0004520 @@ -142460,8 +241814,8 @@ synonym: "morphology of nuclear speck" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0016607 ! nuclear speck -relationship: inheres_in GO:0016607 ! nuclear speck +intersection_of: RO:0000052 GO:0016607 ! inheres in nuclear speck +relationship: RO:0000052 GO:0016607 ! inheres in nuclear speck [Term] id: OBA:0004521 @@ -142471,8 +241825,8 @@ synonym: "morphology of Cajal body" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0015030 ! Cajal body -relationship: inheres_in GO:0015030 ! Cajal body +intersection_of: RO:0000052 GO:0015030 ! inheres in Cajal body +relationship: RO:0000052 GO:0015030 ! inheres in Cajal body [Term] id: OBA:0004522 @@ -142482,8 +241836,8 @@ synonym: "morphology of nuclear lamina" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005652 ! nuclear lamina -relationship: inheres_in GO:0005652 ! nuclear lamina +intersection_of: RO:0000052 GO:0005652 ! inheres in nuclear lamina +relationship: RO:0000052 GO:0005652 ! inheres in nuclear lamina [Term] id: OBA:0004523 @@ -142492,8 +241846,8 @@ def: "The morphology of a sperm flagellum." [AUTO:patterns/patterns/entity_attri synonym: "morphology of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005769 ! motile cilium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0036126 ! sperm flagellum -relationship: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum +relationship: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004524 @@ -142503,7 +241857,7 @@ synonym: "attachment quality of sperm flagellum" EXACT [AUTO:patterns/patterns/e is_a: OBA:0004523 ! sperm flagellum morphology is_a: PATO:0001435 ! attachment quality intersection_of: PATO:0001435 ! attachment quality -intersection_of: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004525 @@ -142512,8 +241866,8 @@ def: "The amount of a intraepithelial lymphocyte." [AUTO:patterns/patterns/entit synonym: "amount of intraepithelial lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002496 ! intraepithelial lymphocyte -relationship: inheres_in CL:0002496 ! intraepithelial lymphocyte +intersection_of: RO:0000052 CL:0002496 ! inheres in intraepithelial lymphocyte +relationship: RO:0000052 CL:0002496 ! inheres in intraepithelial lymphocyte [Term] id: OBA:0004526 @@ -142523,8 +241877,8 @@ synonym: "morphology of acrosomal vesicle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0001669 ! acrosomal vesicle -relationship: inheres_in GO:0001669 ! acrosomal vesicle +intersection_of: RO:0000052 GO:0001669 ! inheres in acrosomal vesicle +relationship: RO:0000052 GO:0001669 ! inheres in acrosomal vesicle [Term] id: OBA:0004527 @@ -142534,7 +241888,7 @@ synonym: "amount of epididymal fat pad" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000778 ! epididymal fat pad quality is_a: OBA:VT0005452 ! adipose amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010412 ! epididymal fat pad +intersection_of: RO:0000052 UBERON:0010412 ! inheres in epididymal fat pad [Term] id: OBA:0004528 @@ -142544,8 +241898,8 @@ synonym: "mass of fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003916 ! fat pad -relationship: inheres_in UBERON:0003916 ! fat pad +intersection_of: RO:0000052 UBERON:0003916 ! inheres in fat pad +relationship: RO:0000052 UBERON:0003916 ! inheres in fat pad [Term] id: OBA:0004529 @@ -142555,7 +241909,7 @@ synonym: "spatial pattern of autopod region" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000572 ! autopod morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002470 ! autopod region +intersection_of: RO:0000052 UBERON:0002470 ! inheres in autopod region [Term] id: OBA:0004530 @@ -142565,7 +241919,7 @@ synonym: "structure of carpal bone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002422 ! bone element structure is_a: OBA:0003518 ! carpal bone morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001435 ! carpal bone +intersection_of: RO:0000052 UBERON:0001435 ! inheres in carpal bone [Term] id: OBA:0004531 @@ -142575,7 +241929,7 @@ synonym: "functionality of astrocyte" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000381 ! astrocyte quality is_a: OBA:VT0003690 ! glia physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000127 ! astrocyte +intersection_of: RO:0000052 CL:0000127 ! inheres in astrocyte [Term] id: OBA:0004532 @@ -142585,7 +241939,7 @@ synonym: "functionality of oligodendrocyte" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000238 ! oligodendrocyte quality is_a: OBA:VT0003690 ! glia physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:0004533 @@ -142594,8 +241948,8 @@ def: "The amount of a vertebral bone 2." [AUTO:patterns/patterns/entity_attribut synonym: "amount of vertebral bone 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002371 ! vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001093 ! vertebral bone 2 -relationship: inheres_in UBERON:0001093 ! vertebral bone 2 +intersection_of: RO:0000052 UBERON:0001093 ! inheres in vertebral bone 2 +relationship: RO:0000052 UBERON:0001093 ! inheres in vertebral bone 2 [Term] id: OBA:0004534 @@ -142605,7 +241959,7 @@ synonym: "amount of granule cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000922 ! granule cell quality is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000120 ! granule cell +intersection_of: RO:0000052 CL:0000120 ! inheres in granule cell [Term] id: OBA:0004535 @@ -142615,8 +241969,8 @@ synonym: "morphology of anterior definitive endoderm" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004046 ! anterior definitive endoderm -relationship: inheres_in UBERON:0004046 ! anterior definitive endoderm +intersection_of: RO:0000052 UBERON:0004046 ! inheres in anterior definitive endoderm +relationship: RO:0000052 UBERON:0004046 ! inheres in anterior definitive endoderm [Term] id: OBA:0004536 @@ -142626,8 +241980,8 @@ synonym: "morphology of parafascicular nucleus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001922 ! parafascicular nucleus -relationship: inheres_in UBERON:0001922 ! parafascicular nucleus +intersection_of: RO:0000052 UBERON:0001922 ! inheres in parafascicular nucleus +relationship: RO:0000052 UBERON:0001922 ! inheres in parafascicular nucleus [Term] id: OBA:0004537 @@ -142637,8 +241991,8 @@ synonym: "morphology of paracentral nucleus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001924 ! paracentral nucleus -relationship: inheres_in UBERON:0001924 ! paracentral nucleus +intersection_of: RO:0000052 UBERON:0001924 ! inheres in paracentral nucleus +relationship: RO:0000052 UBERON:0001924 ! inheres in paracentral nucleus [Term] id: OBA:0004538 @@ -142648,8 +242002,8 @@ synonym: "morphology of central medial nucleus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001923 ! central medial nucleus -relationship: inheres_in UBERON:0001923 ! central medial nucleus +intersection_of: RO:0000052 UBERON:0001923 ! inheres in central medial nucleus +relationship: RO:0000052 UBERON:0001923 ! inheres in central medial nucleus [Term] id: OBA:0004539 @@ -142659,8 +242013,8 @@ synonym: "morphology of medial geniculate body" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001927 ! medial geniculate body -relationship: inheres_in UBERON:0001927 ! medial geniculate body +intersection_of: RO:0000052 UBERON:0001927 ! inheres in medial geniculate body +relationship: RO:0000052 UBERON:0001927 ! inheres in medial geniculate body [Term] id: OBA:0004540 @@ -142670,8 +242024,8 @@ synonym: "morphology of paraventricular nucleus of thalamus" EXACT [AUTO:pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001920 ! paraventricular nucleus of thalamus -relationship: inheres_in UBERON:0001920 ! paraventricular nucleus of thalamus +intersection_of: RO:0000052 UBERON:0001920 ! inheres in paraventricular nucleus of thalamus +relationship: RO:0000052 UBERON:0001920 ! inheres in paraventricular nucleus of thalamus [Term] id: OBA:0004541 @@ -142681,8 +242035,8 @@ synonym: "functionality of embryonic tissue" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005291 ! embryonic tissue -relationship: inheres_in UBERON:0005291 ! embryonic tissue +intersection_of: RO:0000052 UBERON:0005291 ! inheres in embryonic tissue +relationship: RO:0000052 UBERON:0005291 ! inheres in embryonic tissue [Term] id: OBA:0004542 @@ -142692,8 +242046,8 @@ synonym: "amount of choroid plexus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001886 ! choroid plexus -relationship: inheres_in UBERON:0001886 ! choroid plexus +intersection_of: RO:0000052 UBERON:0001886 ! inheres in choroid plexus +relationship: RO:0000052 UBERON:0001886 ! inheres in choroid plexus [Term] id: OBA:0004543 @@ -142707,8 +242061,8 @@ def: "The functionality of a type D enteroendocrine cell." [AUTO:patterns/patter synonym: "functionality of type D enteroendocrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000502 ! type D enteroendocrine cell -relationship: inheres_in CL:0000502 ! type D enteroendocrine cell +intersection_of: RO:0000052 CL:0000502 ! inheres in type D enteroendocrine cell +relationship: RO:0000052 CL:0000502 ! inheres in type D enteroendocrine cell [Term] id: OBA:0004545 @@ -142718,8 +242072,8 @@ synonym: "structure of placenta junctional zone" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003972 ! placenta junctional zone -relationship: inheres_in UBERON:0003972 ! placenta junctional zone +intersection_of: RO:0000052 UBERON:0003972 ! inheres in placenta junctional zone +relationship: RO:0000052 UBERON:0003972 ! inheres in placenta junctional zone [Term] id: OBA:0004546 @@ -142728,8 +242082,8 @@ def: "The morphology of a glycogen accumulating cell." [AUTO:patterns/patterns/e synonym: "morphology of glycogen accumulating cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000326 ! glycogen accumulating cell -relationship: inheres_in CL:0000326 ! glycogen accumulating cell +intersection_of: RO:0000052 CL:0000326 ! inheres in glycogen accumulating cell +relationship: RO:0000052 CL:0000326 ! inheres in glycogen accumulating cell [Term] id: OBA:0004547 @@ -142738,8 +242092,8 @@ def: "The morphology of a spongiotrophoblast cell." [AUTO:patterns/patterns/enti synonym: "morphology of spongiotrophoblast cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002499 ! spongiotrophoblast cell -relationship: inheres_in CL:0002499 ! spongiotrophoblast cell +intersection_of: RO:0000052 CL:0002499 ! inheres in spongiotrophoblast cell +relationship: RO:0000052 CL:0002499 ! inheres in spongiotrophoblast cell [Term] id: OBA:0004548 @@ -142749,8 +242103,8 @@ synonym: "morphology of lacrimal apparatus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001750 ! lacrimal apparatus -relationship: inheres_in UBERON:0001750 ! lacrimal apparatus +intersection_of: RO:0000052 UBERON:0001750 ! inheres in lacrimal apparatus +relationship: RO:0000052 UBERON:0001750 ! inheres in lacrimal apparatus [Term] id: OBA:0004549 @@ -142760,8 +242114,8 @@ synonym: "morphology of nasolacrimal duct" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002392 ! nasolacrimal duct -relationship: inheres_in UBERON:0002392 ! nasolacrimal duct +intersection_of: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct +relationship: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct [Term] id: OBA:0004550 @@ -142771,8 +242125,8 @@ synonym: "structure of nasal concha of ethmoid bone" EXACT [AUTO:patterns/patter is_a: OBA:0002422 ! bone element structure is_a: OBA:VT0002244 ! turbinated bone morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003973 ! nasal concha of ethmoid bone -relationship: inheres_in UBERON:0003973 ! nasal concha of ethmoid bone +intersection_of: RO:0000052 UBERON:0003973 ! inheres in nasal concha of ethmoid bone +relationship: RO:0000052 UBERON:0003973 ! inheres in nasal concha of ethmoid bone [Term] id: OBA:0004551 @@ -142781,8 +242135,8 @@ def: "The size of a nasal concha of ethmoid bone." [AUTO:patterns/patterns/entit synonym: "size of nasal concha of ethmoid bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003994 ! turbinate bone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003973 ! nasal concha of ethmoid bone -relationship: inheres_in UBERON:0003973 ! nasal concha of ethmoid bone +intersection_of: RO:0000052 UBERON:0003973 ! inheres in nasal concha of ethmoid bone +relationship: RO:0000052 UBERON:0003973 ! inheres in nasal concha of ethmoid bone [Term] id: OBA:0004552 @@ -142792,8 +242146,8 @@ synonym: "mass of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000996 ! vagina -relationship: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina +relationship: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:0004553 @@ -142803,8 +242157,8 @@ synonym: "morphology of liver parenchyma" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001280 ! liver parenchyma -relationship: inheres_in UBERON:0001280 ! liver parenchyma +intersection_of: RO:0000052 UBERON:0001280 ! inheres in liver parenchyma +relationship: RO:0000052 UBERON:0001280 ! inheres in liver parenchyma [Term] id: OBA:0004554 @@ -142814,8 +242168,8 @@ synonym: "morphology of liver lobule" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004647 ! liver lobule -relationship: inheres_in UBERON:0004647 ! liver lobule +intersection_of: RO:0000052 UBERON:0004647 ! inheres in liver lobule +relationship: RO:0000052 UBERON:0004647 ! inheres in liver lobule [Term] id: OBA:0004555 @@ -142825,8 +242179,8 @@ synonym: "morphology of liver perisinusoidal space" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006729 ! liver perisinusoidal space -relationship: inheres_in UBERON:0006729 ! liver perisinusoidal space +intersection_of: RO:0000052 UBERON:0006729 ! inheres in liver perisinusoidal space +relationship: RO:0000052 UBERON:0006729 ! inheres in liver perisinusoidal space [Term] id: OBA:0004556 @@ -142836,8 +242190,8 @@ synonym: "morphology of hepatic sinusoid" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004739 ! blood vessel endothelium morphology is_a: OBA:VT0000087 ! capillary morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001281 ! hepatic sinusoid -relationship: inheres_in UBERON:0001281 ! hepatic sinusoid +intersection_of: RO:0000052 UBERON:0001281 ! inheres in hepatic sinusoid +relationship: RO:0000052 UBERON:0001281 ! inheres in hepatic sinusoid [Term] id: OBA:0004557 @@ -142846,8 +242200,8 @@ def: "The morphology of a hepatic stellate cell." [AUTO:patterns/patterns/entity synonym: "morphology of hepatic stellate cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000632 ! hepatic stellate cell -relationship: inheres_in CL:0000632 ! hepatic stellate cell +intersection_of: RO:0000052 CL:0000632 ! inheres in hepatic stellate cell +relationship: RO:0000052 CL:0000632 ! inheres in hepatic stellate cell [Term] id: OBA:0004558 @@ -142857,8 +242211,8 @@ synonym: "morphology of bile canaliculus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001283 ! bile canaliculus -relationship: inheres_in UBERON:0001283 ! bile canaliculus +intersection_of: RO:0000052 UBERON:0001283 ! inheres in bile canaliculus +relationship: RO:0000052 UBERON:0001283 ! inheres in bile canaliculus [Term] id: OBA:0004559 @@ -142868,8 +242222,8 @@ synonym: "morphology of portal lobule" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001171 ! portal lobule -relationship: inheres_in UBERON:0001171 ! portal lobule +intersection_of: RO:0000052 UBERON:0001171 ! inheres in portal lobule +relationship: RO:0000052 UBERON:0001171 ! inheres in portal lobule [Term] id: OBA:0004560 @@ -142879,8 +242233,8 @@ synonym: "morphology of portal triad" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001279 ! portal triad -relationship: inheres_in UBERON:0001279 ! portal triad +intersection_of: RO:0000052 UBERON:0001279 ! inheres in portal triad +relationship: RO:0000052 UBERON:0001279 ! inheres in portal triad [Term] id: OBA:0004561 @@ -142890,8 +242244,8 @@ synonym: "osmolality of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002027 ! osmolality intersection_of: PATO:0002027 ! osmolality -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:0004562 @@ -142901,8 +242255,8 @@ synonym: "amount of anus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001245 ! anus -relationship: inheres_in UBERON:0001245 ! anus +intersection_of: RO:0000052 UBERON:0001245 ! inheres in anus +relationship: RO:0000052 UBERON:0001245 ! inheres in anus [Term] id: OBA:0004563 @@ -142912,8 +242266,8 @@ synonym: "amount of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001153 ! caecum -relationship: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum +relationship: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:0004564 @@ -142923,8 +242277,8 @@ synonym: "amount of vibrissa unit" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0011933 ! vibrissa unit -relationship: inheres_in UBERON:0011933 ! vibrissa unit +intersection_of: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit +relationship: RO:0000052 UBERON:0011933 ! inheres in vibrissa unit [Term] id: OBA:0004566 @@ -142934,8 +242288,8 @@ synonym: "morphology of sesamoid bone of gastrocnemius" EXACT [AUTO:patterns/pat is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003467 ! sesamoid bone of gastrocnemius -relationship: inheres_in UBERON:0003467 ! sesamoid bone of gastrocnemius +intersection_of: RO:0000052 UBERON:0003467 ! inheres in sesamoid bone of gastrocnemius +relationship: RO:0000052 UBERON:0003467 ! inheres in sesamoid bone of gastrocnemius [Term] id: OBA:0004567 @@ -142945,8 +242299,8 @@ synonym: "duration of ovulation cycle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in GO:0042698 ! ovulation cycle -relationship: inheres_in GO:0042698 ! ovulation cycle +intersection_of: RO:0000052 GO:0042698 ! inheres in ovulation cycle +relationship: RO:0000052 GO:0042698 ! inheres in ovulation cycle [Term] id: OBA:0004568 @@ -142956,7 +242310,7 @@ synonym: "onset quality of estrus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000910 ! estrus quality is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060209 ! estrus +intersection_of: RO:0000052 GO:0060209 ! inheres in estrus [Term] id: OBA:0004569 @@ -142966,8 +242320,8 @@ synonym: "amount of ovulation cycle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0042698 ! ovulation cycle -relationship: inheres_in GO:0042698 ! ovulation cycle +intersection_of: RO:0000052 GO:0042698 ! inheres in ovulation cycle +relationship: RO:0000052 GO:0042698 ! inheres in ovulation cycle [Term] id: OBA:0004570 @@ -142977,7 +242331,7 @@ synonym: "occurrence of diestrus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000769 ! diestrus quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060207 ! diestrus +intersection_of: RO:0000052 GO:0060207 ! inheres in diestrus [Term] id: OBA:0004571 @@ -142987,7 +242341,7 @@ synonym: "occurrence of proestrus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000752 ! proestrus quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060208 ! proestrus +intersection_of: RO:0000052 GO:0060208 ! inheres in proestrus [Term] id: OBA:0004572 @@ -142997,7 +242351,7 @@ synonym: "occurrence of estrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000910 ! estrus quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060209 ! estrus +intersection_of: RO:0000052 GO:0060209 ! inheres in estrus [Term] id: OBA:0004573 @@ -143007,7 +242361,7 @@ synonym: "amount of estrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000910 ! estrus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060209 ! estrus +intersection_of: RO:0000052 GO:0060209 ! inheres in estrus [Term] id: OBA:0004574 @@ -143016,8 +242370,8 @@ def: "The morphology of a brain meninx." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of brain meninx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005623 ! meninges morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003547 ! brain meninx -relationship: inheres_in UBERON:0003547 ! brain meninx +intersection_of: RO:0000052 UBERON:0003547 ! inheres in brain meninx +relationship: RO:0000052 UBERON:0003547 ! inheres in brain meninx [Term] id: OBA:0004575 @@ -143027,7 +242381,7 @@ synonym: "morphology of meninx of spinal cord" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000267 ! meninx of spinal cord quality is_a: OBA:VT0005623 ! meninges morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003292 ! meninx of spinal cord +intersection_of: RO:0000052 UBERON:0003292 ! inheres in meninx of spinal cord [Term] id: OBA:0004576 @@ -143037,8 +242391,8 @@ synonym: "morphology of brain dura mater" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004574 ! brain meninx morphology is_a: OBA:1000255 ! dura mater quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002092 ! brain dura mater -relationship: inheres_in UBERON:0002092 ! brain dura mater +intersection_of: RO:0000052 UBERON:0002092 ! inheres in brain dura mater +relationship: RO:0000052 UBERON:0002092 ! inheres in brain dura mater [Term] id: OBA:0004577 @@ -143047,8 +242401,8 @@ def: "The morphology of a brain pia mater." [AUTO:patterns/patterns/entity_attri synonym: "morphology of brain pia mater" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004574 ! brain meninx morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003549 ! brain pia mater -relationship: inheres_in UBERON:0003549 ! brain pia mater +intersection_of: RO:0000052 UBERON:0003549 ! inheres in brain pia mater +relationship: RO:0000052 UBERON:0003549 ! inheres in brain pia mater [Term] id: OBA:0004578 @@ -143058,8 +242412,8 @@ synonym: "morphology of subarachnoid space" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000315 ! subarachnoid space -relationship: inheres_in UBERON:0000315 ! subarachnoid space +intersection_of: RO:0000052 UBERON:0000315 ! inheres in subarachnoid space +relationship: RO:0000052 UBERON:0000315 ! inheres in subarachnoid space [Term] id: OBA:0004579 @@ -143068,8 +242422,8 @@ def: "The morphology of a chiasmatic cistern." [AUTO:patterns/patterns/entity_at synonym: "morphology of chiasmatic cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004583 ! subarachnoid cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002898 ! chiasmatic cistern -relationship: inheres_in UBERON:0002898 ! chiasmatic cistern +intersection_of: RO:0000052 UBERON:0002898 ! inheres in chiasmatic cistern +relationship: RO:0000052 UBERON:0002898 ! inheres in chiasmatic cistern [Term] id: OBA:0004580 @@ -143078,8 +242432,8 @@ def: "The morphology of a basal cistern." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of basal cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004583 ! subarachnoid cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004047 ! basal cistern -relationship: inheres_in UBERON:0004047 ! basal cistern +intersection_of: RO:0000052 UBERON:0004047 ! inheres in basal cistern +relationship: RO:0000052 UBERON:0004047 ! inheres in basal cistern [Term] id: OBA:0004581 @@ -143088,8 +242442,8 @@ def: "The morphology of a pontine cistern." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pontine cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004583 ! subarachnoid cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004048 ! pontine cistern -relationship: inheres_in UBERON:0004048 ! pontine cistern +intersection_of: RO:0000052 UBERON:0004048 ! inheres in pontine cistern +relationship: RO:0000052 UBERON:0004048 ! inheres in pontine cistern [Term] id: OBA:0004582 @@ -143098,8 +242452,8 @@ def: "The morphology of a cerebellomedullary cistern." [AUTO:patterns/patterns/e synonym: "morphology of cerebellomedullary cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004583 ! subarachnoid cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004049 ! cerebellomedullary cistern -relationship: inheres_in UBERON:0004049 ! cerebellomedullary cistern +intersection_of: RO:0000052 UBERON:0004049 ! inheres in cerebellomedullary cistern +relationship: RO:0000052 UBERON:0004049 ! inheres in cerebellomedullary cistern [Term] id: OBA:0004583 @@ -143108,8 +242462,8 @@ def: "The morphology of a subarachnoid cistern." [AUTO:patterns/patterns/entity_ synonym: "morphology of subarachnoid cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004578 ! subarachnoid space morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004050 ! subarachnoid cistern -relationship: inheres_in UBERON:0004050 ! subarachnoid cistern +intersection_of: RO:0000052 UBERON:0004050 ! inheres in subarachnoid cistern +relationship: RO:0000052 UBERON:0004050 ! inheres in subarachnoid cistern [Term] id: OBA:0004584 @@ -143118,8 +242472,8 @@ def: "The morphology of a posterior cerebellomedullary cistern." [AUTO:patterns/ synonym: "morphology of posterior cerebellomedullary cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004582 ! cerebellomedullary cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005974 ! posterior cerebellomedullary cistern -relationship: inheres_in UBERON:0005974 ! posterior cerebellomedullary cistern +intersection_of: RO:0000052 UBERON:0005974 ! inheres in posterior cerebellomedullary cistern +relationship: RO:0000052 UBERON:0005974 ! inheres in posterior cerebellomedullary cistern [Term] id: OBA:0004585 @@ -143128,8 +242482,8 @@ def: "The morphology of a lateral cerebellomedullary cistern." [AUTO:patterns/pa synonym: "morphology of lateral cerebellomedullary cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004582 ! cerebellomedullary cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004051 ! lateral cerebellomedullary cistern -relationship: inheres_in UBERON:0004051 ! lateral cerebellomedullary cistern +intersection_of: RO:0000052 UBERON:0004051 ! inheres in lateral cerebellomedullary cistern +relationship: RO:0000052 UBERON:0004051 ! inheres in lateral cerebellomedullary cistern [Term] id: OBA:0004586 @@ -143138,8 +242492,8 @@ def: "The morphology of a quadrigeminal cistern." [AUTO:patterns/patterns/entity synonym: "morphology of quadrigeminal cistern" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004583 ! subarachnoid cistern morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004052 ! quadrigeminal cistern -relationship: inheres_in UBERON:0004052 ! quadrigeminal cistern +intersection_of: RO:0000052 UBERON:0004052 ! inheres in quadrigeminal cistern +relationship: RO:0000052 UBERON:0004052 ! inheres in quadrigeminal cistern [Term] id: OBA:0004587 @@ -143149,8 +242503,8 @@ synonym: "amount of posterior cerebellomedullary cistern" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005974 ! posterior cerebellomedullary cistern -relationship: inheres_in UBERON:0005974 ! posterior cerebellomedullary cistern +intersection_of: RO:0000052 UBERON:0005974 ! inheres in posterior cerebellomedullary cistern +relationship: RO:0000052 UBERON:0005974 ! inheres in posterior cerebellomedullary cistern [Term] id: OBA:0004588 @@ -143160,7 +242514,7 @@ synonym: "amount of inferior colliculus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000897 ! inferior colliculus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001946 ! inferior colliculus +intersection_of: RO:0000052 UBERON:0001946 ! inheres in inferior colliculus [Term] id: OBA:0004589 @@ -143170,7 +242524,7 @@ synonym: "amount of superior colliculus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000810 ! superior colliculus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001945 ! superior colliculus +intersection_of: RO:0000052 UBERON:0001945 ! inheres in superior colliculus [Term] id: OBA:0004590 @@ -143180,8 +242534,8 @@ synonym: "amount of corpora quadrigemina" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002259 ! corpora quadrigemina -relationship: inheres_in UBERON:0002259 ! corpora quadrigemina +intersection_of: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina +relationship: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina [Term] id: OBA:0004591 @@ -143191,7 +242545,7 @@ synonym: "occurrence of metestrus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000868 ! metestrus quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060210 ! metestrus +intersection_of: RO:0000052 GO:0060210 ! inheres in metestrus [Term] id: OBA:0004592 @@ -143201,8 +242555,8 @@ synonym: "morphology of pedal digit 1" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000314 ! pedal digit quality is_a: OBA:VT0002110 ! digit morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003631 ! pedal digit 1 -relationship: inheres_in UBERON:0003631 ! pedal digit 1 +intersection_of: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 +relationship: RO:0000052 UBERON:0003631 ! inheres in pedal digit 1 [Term] id: OBA:0004593 @@ -143212,7 +242566,7 @@ synonym: "size of proximal convoluted tubule" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0002705 ! kidney tubule size trait is_a: OBA:VT0010069 ! proximal convoluted tubule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001287 ! proximal convoluted tubule +intersection_of: RO:0000052 UBERON:0001287 ! inheres in proximal convoluted tubule [Term] id: OBA:0004594 @@ -143222,7 +242576,7 @@ synonym: "size of distal convoluted tubule" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0002705 ! kidney tubule size trait is_a: OBA:VT0010070 ! distal convoluted tubule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001292 ! distal convoluted tubule +intersection_of: RO:0000052 UBERON:0001292 ! inheres in distal convoluted tubule [Term] id: OBA:0004595 @@ -143232,8 +242586,8 @@ synonym: "morphology of anal canal" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000159 ! anal canal -relationship: inheres_in UBERON:0000159 ! anal canal +intersection_of: RO:0000052 UBERON:0000159 ! inheres in anal canal +relationship: RO:0000052 UBERON:0000159 ! inheres in anal canal [Term] id: OBA:0004596 @@ -143243,8 +242597,8 @@ synonym: "morphology of internal anal sphincter" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003692 ! muscle organ morphology is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001244 ! internal anal sphincter -relationship: inheres_in UBERON:0001244 ! internal anal sphincter +intersection_of: RO:0000052 UBERON:0001244 ! inheres in internal anal sphincter +relationship: RO:0000052 UBERON:0001244 ! inheres in internal anal sphincter [Term] id: OBA:0004597 @@ -143254,7 +242608,7 @@ synonym: "rate of interleukin-21 production" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0009056 ! interleukin-21 secretion trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032625 ! interleukin-21 production +intersection_of: RO:0000052 GO:0032625 ! inheres in interleukin-21 production [Term] id: OBA:0004598 @@ -143264,7 +242618,7 @@ synonym: "mass of fallopian tube" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000290 ! fallopian tube quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003889 ! fallopian tube +intersection_of: RO:0000052 UBERON:0003889 ! inheres in fallopian tube [Term] id: OBA:0004599 @@ -143274,8 +242628,8 @@ synonym: "amount of upper part of vagina" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000290 ! fallopian tube quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003974 ! upper part of vagina -relationship: inheres_in UBERON:0003974 ! upper part of vagina +intersection_of: RO:0000052 UBERON:0003974 ! inheres in upper part of vagina +relationship: RO:0000052 UBERON:0003974 ! inheres in upper part of vagina [Term] id: OBA:0004600 @@ -143285,8 +242639,8 @@ synonym: "amount of mesonephric duct" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003074 ! mesonephric duct -relationship: inheres_in UBERON:0003074 ! mesonephric duct +intersection_of: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct +relationship: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct [Term] id: OBA:0004601 @@ -143296,7 +242650,7 @@ synonym: "degeneration of mesonephric duct" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0003827 ! Wolffian duct morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0003074 ! mesonephric duct +intersection_of: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct [Term] id: OBA:0004602 @@ -143305,8 +242659,8 @@ def: "The morphology of a upper part of vagina." [AUTO:patterns/patterns/entity_ synonym: "morphology of upper part of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003574 ! oviduct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003974 ! upper part of vagina -relationship: inheres_in UBERON:0003974 ! upper part of vagina +intersection_of: RO:0000052 UBERON:0003974 ! inheres in upper part of vagina +relationship: RO:0000052 UBERON:0003974 ! inheres in upper part of vagina [Term] id: OBA:0004603 @@ -143316,8 +242670,8 @@ synonym: "position of intervertebral disk" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk -relationship: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk +relationship: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:0004604 @@ -143327,7 +242681,7 @@ synonym: "structure of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001120 ! uterus morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0004605 @@ -143337,7 +242691,7 @@ synonym: "size of uterine horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010394 ! uterine horn morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002247 ! uterine horn +intersection_of: RO:0000052 UBERON:0002247 ! inheres in uterine horn [Term] id: OBA:0004606 @@ -143347,7 +242701,7 @@ synonym: "degeneration of oocyte" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0001125 ! oocyte morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000023 ! oocyte +intersection_of: RO:0000052 CL:0000023 ! inheres in oocyte [Term] id: OBA:0004607 @@ -143357,8 +242711,8 @@ synonym: "morphology of endometrial gland" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005808 ! female reproductive gland morphology is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002451 ! endometrial gland -relationship: inheres_in UBERON:0002451 ! endometrial gland +intersection_of: RO:0000052 UBERON:0002451 ! inheres in endometrial gland +relationship: RO:0000052 UBERON:0002451 ! inheres in endometrial gland [Term] id: OBA:0004608 @@ -143368,8 +242722,8 @@ synonym: "amount of endometrial gland" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002451 ! endometrial gland -relationship: inheres_in UBERON:0002451 ! endometrial gland +intersection_of: RO:0000052 UBERON:0002451 ! inheres in endometrial gland +relationship: RO:0000052 UBERON:0002451 ! inheres in endometrial gland [Term] id: OBA:0004609 @@ -143378,8 +242732,8 @@ def: "The functionality of a decidual natural killer cell, human." [AUTO:pattern synonym: "functionality of decidual natural killer cell, human" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005069 ! NK cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002343 ! decidual natural killer cell, human -relationship: inheres_in CL:0002343 ! decidual natural killer cell, human +intersection_of: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human +relationship: RO:0000052 CL:0002343 ! inheres in decidual natural killer cell, human [Term] id: OBA:0004610 @@ -143389,8 +242743,8 @@ synonym: "morphology of glans penis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001299 ! glans penis -relationship: inheres_in UBERON:0001299 ! glans penis +intersection_of: RO:0000052 UBERON:0001299 ! inheres in glans penis +relationship: RO:0000052 UBERON:0001299 ! inheres in glans penis [Term] id: OBA:0004611 @@ -143399,8 +242753,8 @@ def: "The morphology of a os penis." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of os penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0006101 ! bone of reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006435 ! os penis -relationship: inheres_in UBERON:0006435 ! os penis +intersection_of: RO:0000052 UBERON:0006435 ! inheres in os penis +relationship: RO:0000052 UBERON:0006435 ! inheres in os penis [Term] id: OBA:0004612 @@ -143410,7 +242764,7 @@ synonym: "size of os penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004611 ! os penis morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006435 ! os penis +intersection_of: RO:0000052 UBERON:0006435 ! inheres in os penis [Term] id: OBA:0004613 @@ -143420,8 +242774,8 @@ synonym: "position of penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000989 ! penis -relationship: inheres_in UBERON:0000989 ! penis +intersection_of: RO:0000052 UBERON:0000989 ! inheres in penis +relationship: RO:0000052 UBERON:0000989 ! inheres in penis [Term] id: OBA:0004614 @@ -143435,8 +242789,8 @@ def: "The mass of a type B pancreatic cell." [AUTO:patterns/patterns/entity_attr synonym: "mass of type B pancreatic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000036 ! cell mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in CL:0000169 ! type B pancreatic cell -relationship: inheres_in CL:0000169 ! type B pancreatic cell +intersection_of: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell +relationship: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell [Term] id: OBA:0004616 @@ -143446,7 +242800,7 @@ synonym: "size of brown fat cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004185 ! fat cell size is_a: OBA:VT0010061 ! brown adipocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000449 ! brown fat cell +intersection_of: RO:0000052 CL:0000449 ! inheres in brown fat cell [Term] id: OBA:0004617 @@ -143456,8 +242810,8 @@ synonym: "amount of brown fat cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000449 ! brown fat cell -relationship: inheres_in CL:0000449 ! brown fat cell +intersection_of: RO:0000052 CL:0000449 ! inheres in brown fat cell +relationship: RO:0000052 CL:0000449 ! inheres in brown fat cell [Term] id: OBA:0004618 @@ -143467,8 +242821,8 @@ synonym: "amount of white fat cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000448 ! white fat cell -relationship: inheres_in CL:0000448 ! white fat cell +intersection_of: RO:0000052 CL:0000448 ! inheres in white fat cell +relationship: RO:0000052 CL:0000448 ! inheres in white fat cell [Term] id: OBA:0004619 @@ -143478,8 +242832,8 @@ synonym: "amount of Mullerian duct regression" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001880 ! Mullerian duct regression -relationship: inheres_in GO:0001880 ! Mullerian duct regression +intersection_of: RO:0000052 GO:0001880 ! inheres in Mullerian duct regression +relationship: RO:0000052 GO:0001880 ! inheres in Mullerian duct regression [Term] id: OBA:0004620 @@ -143489,7 +242843,7 @@ synonym: "size of efferent duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:1000725 ! efferent duct quality intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006946 ! efferent duct +intersection_of: RO:0000052 UBERON:0006946 ! inheres in efferent duct [Term] id: OBA:0004621 @@ -143499,7 +242853,7 @@ synonym: "amount of prepulse inhibition" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0003088 ! prepulse inhibition trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060134 ! prepulse inhibition +intersection_of: RO:0000052 GO:0060134 ! inheres in prepulse inhibition [Term] id: OBA:0004622 @@ -143509,8 +242863,8 @@ synonym: "morphology of pancreatic duct" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007329 ! pancreatic duct -relationship: inheres_in UBERON:0007329 ! pancreatic duct +intersection_of: RO:0000052 UBERON:0007329 ! inheres in pancreatic duct +relationship: RO:0000052 UBERON:0007329 ! inheres in pancreatic duct [Term] id: OBA:0004623 @@ -143520,7 +242874,7 @@ synonym: "size of pancreatic duct" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004622 ! pancreatic duct morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007329 ! pancreatic duct +intersection_of: RO:0000052 UBERON:0007329 ! inheres in pancreatic duct [Term] id: OBA:0004624 @@ -143530,8 +242884,8 @@ synonym: "morphology of pancreatic acinus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001263 ! pancreatic acinus -relationship: inheres_in UBERON:0001263 ! pancreatic acinus +intersection_of: RO:0000052 UBERON:0001263 ! inheres in pancreatic acinus +relationship: RO:0000052 UBERON:0001263 ! inheres in pancreatic acinus [Term] id: OBA:0004625 @@ -143540,8 +242894,8 @@ def: "The functionality of a pancreatic acinar cell." [AUTO:patterns/patterns/en synonym: "functionality of pancreatic acinar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002064 ! pancreatic acinar cell -relationship: inheres_in CL:0002064 ! pancreatic acinar cell +intersection_of: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell +relationship: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell [Term] id: OBA:0004626 @@ -143550,8 +242904,8 @@ def: "The size of a pancreatic acinar cell." [AUTO:patterns/patterns/entity_attr synonym: "size of pancreatic acinar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004152 ! acinar cell size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0002064 ! pancreatic acinar cell -relationship: inheres_in CL:0002064 ! pancreatic acinar cell +intersection_of: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell +relationship: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell [Term] id: OBA:0004627 @@ -143561,7 +242915,7 @@ synonym: "size of pancreatic acinus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004624 ! pancreatic acinus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001263 ! pancreatic acinus +intersection_of: RO:0000052 UBERON:0001263 ! inheres in pancreatic acinus [Term] id: OBA:0004628 @@ -143571,8 +242925,8 @@ synonym: "amount of pancreatic acinus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001263 ! pancreatic acinus -relationship: inheres_in UBERON:0001263 ! pancreatic acinus +intersection_of: RO:0000052 UBERON:0001263 ! inheres in pancreatic acinus +relationship: RO:0000052 UBERON:0001263 ! inheres in pancreatic acinus [Term] id: OBA:0004629 @@ -143582,8 +242936,8 @@ synonym: "displaced of pancreatic acinar cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000076 ! attribute of cell is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0002064 ! pancreatic acinar cell -relationship: inheres_in CL:0002064 ! pancreatic acinar cell +intersection_of: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell +relationship: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell [Term] id: OBA:0004630 @@ -143593,8 +242947,8 @@ synonym: "amount of pancreatic acinar cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002064 ! pancreatic acinar cell -relationship: inheres_in CL:0002064 ! pancreatic acinar cell +intersection_of: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell +relationship: RO:0000052 CL:0002064 ! inheres in pancreatic acinar cell [Term] id: OBA:0004631 @@ -143604,8 +242958,8 @@ synonym: "amount of pancreatic duct" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007329 ! pancreatic duct -relationship: inheres_in UBERON:0007329 ! pancreatic duct +intersection_of: RO:0000052 UBERON:0007329 ! inheres in pancreatic duct +relationship: RO:0000052 UBERON:0007329 ! inheres in pancreatic duct [Term] id: OBA:0004632 @@ -143615,8 +242969,8 @@ synonym: "amount of islet of Langerhans" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000006 ! islet of Langerhans -relationship: inheres_in UBERON:0000006 ! islet of Langerhans +intersection_of: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans +relationship: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans [Term] id: OBA:0004633 @@ -143626,8 +242980,8 @@ synonym: "amount of pancreatic A cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000171 ! pancreatic A cell -relationship: inheres_in CL:0000171 ! pancreatic A cell +intersection_of: RO:0000052 CL:0000171 ! inheres in pancreatic A cell +relationship: RO:0000052 CL:0000171 ! inheres in pancreatic A cell [Term] id: OBA:0004634 @@ -143636,8 +242990,8 @@ def: "The amount of a pancreatic D cell." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pancreatic D cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004635 ! type D enteroendocrine cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000173 ! pancreatic D cell -relationship: inheres_in CL:0000173 ! pancreatic D cell +intersection_of: RO:0000052 CL:0000173 ! inheres in pancreatic D cell +relationship: RO:0000052 CL:0000173 ! inheres in pancreatic D cell [Term] id: OBA:0004635 @@ -143647,8 +243001,8 @@ synonym: "amount of type D enteroendocrine cell" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000502 ! type D enteroendocrine cell -relationship: inheres_in CL:0000502 ! type D enteroendocrine cell +intersection_of: RO:0000052 CL:0000502 ! inheres in type D enteroendocrine cell +relationship: RO:0000052 CL:0000502 ! inheres in type D enteroendocrine cell [Term] id: OBA:0004636 @@ -143657,8 +243011,8 @@ def: "The morphology of a PP cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of PP cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000696 ! PP cell -relationship: inheres_in CL:0000696 ! PP cell +intersection_of: RO:0000052 CL:0000696 ! inheres in PP cell +relationship: RO:0000052 CL:0000696 ! inheres in PP cell [Term] id: OBA:0004637 @@ -143668,8 +243022,8 @@ synonym: "amount of PP cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000696 ! PP cell -relationship: inheres_in CL:0000696 ! PP cell +intersection_of: RO:0000052 CL:0000696 ! inheres in PP cell +relationship: RO:0000052 CL:0000696 ! inheres in PP cell [Term] id: OBA:0004638 @@ -143678,8 +243032,8 @@ def: "The morphology of a pancreatic epsilon cell." [AUTO:patterns/patterns/enti synonym: "morphology of pancreatic epsilon cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0005019 ! pancreatic epsilon cell -relationship: inheres_in CL:0005019 ! pancreatic epsilon cell +intersection_of: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell +relationship: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell [Term] id: OBA:0004639 @@ -143689,7 +243043,7 @@ synonym: "altered number of of pancreatic epsilon cell" EXACT [AUTO:patterns/pat is_a: OBA:0004638 ! pancreatic epsilon cell morphology is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0005019 ! pancreatic epsilon cell +intersection_of: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell [Term] id: OBA:0004640 @@ -143699,8 +243053,8 @@ synonym: "amount of pancreatic epsilon cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0005019 ! pancreatic epsilon cell -relationship: inheres_in CL:0005019 ! pancreatic epsilon cell +intersection_of: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell +relationship: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell [Term] id: OBA:0004641 @@ -143709,8 +243063,8 @@ def: "The functionality of a pancreatic epsilon cell." [AUTO:patterns/patterns/e synonym: "functionality of pancreatic epsilon cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0005019 ! pancreatic epsilon cell -relationship: inheres_in CL:0005019 ! pancreatic epsilon cell +intersection_of: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell +relationship: RO:0000052 CL:0005019 ! inheres in pancreatic epsilon cell [Term] id: OBA:0004642 @@ -143719,8 +243073,8 @@ def: "The functionality of a PP cell." [AUTO:patterns/patterns/entity_attribute] synonym: "functionality of PP cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000696 ! PP cell -relationship: inheres_in CL:0000696 ! PP cell +intersection_of: RO:0000052 CL:0000696 ! inheres in PP cell +relationship: RO:0000052 CL:0000696 ! inheres in PP cell [Term] id: OBA:0004643 @@ -143730,8 +243084,8 @@ synonym: "morphology of male reproductive organ" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003135 ! male reproductive organ -relationship: inheres_in UBERON:0003135 ! male reproductive organ +intersection_of: RO:0000052 UBERON:0003135 ! inheres in male reproductive organ +relationship: RO:0000052 UBERON:0003135 ! inheres in male reproductive organ [Term] id: OBA:0004644 @@ -143740,8 +243094,8 @@ def: "The morphology of a external male genitalia." [AUTO:patterns/patterns/enti synonym: "morphology of external male genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004643 ! male reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004053 ! external male genitalia -relationship: inheres_in UBERON:0004053 ! external male genitalia +intersection_of: RO:0000052 UBERON:0004053 ! inheres in external male genitalia +relationship: RO:0000052 UBERON:0004053 ! inheres in external male genitalia [Term] id: OBA:0004645 @@ -143751,7 +243105,7 @@ synonym: "size of external male genitalia" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002407 ! external genitalia size is_a: OBA:0004644 ! external male genitalia morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004053 ! external male genitalia +intersection_of: RO:0000052 UBERON:0004053 ! inheres in external male genitalia [Term] id: OBA:0004646 @@ -143760,8 +243114,8 @@ def: "The amount of a external male genitalia." [AUTO:patterns/patterns/entity_a synonym: "amount of external male genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002005 ! external genitalia amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004053 ! external male genitalia -relationship: inheres_in UBERON:0004053 ! external male genitalia +intersection_of: RO:0000052 UBERON:0004053 ! inheres in external male genitalia +relationship: RO:0000052 UBERON:0004053 ! inheres in external male genitalia [Term] id: OBA:0004647 @@ -143770,8 +243124,8 @@ def: "The morphology of a internal male genitalia." [AUTO:patterns/patterns/enti synonym: "morphology of internal male genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004643 ! male reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004054 ! internal male genitalia -relationship: inheres_in UBERON:0004054 ! internal male genitalia +intersection_of: RO:0000052 UBERON:0004054 ! inheres in internal male genitalia +relationship: RO:0000052 UBERON:0004054 ! inheres in internal male genitalia [Term] id: OBA:0004648 @@ -143780,8 +243134,8 @@ def: "The amount of a internal male genitalia." [AUTO:patterns/patterns/entity_a synonym: "amount of internal male genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002851 ! internal genitalia amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004054 ! internal male genitalia -relationship: inheres_in UBERON:0004054 ! internal male genitalia +intersection_of: RO:0000052 UBERON:0004054 ! inheres in internal male genitalia +relationship: RO:0000052 UBERON:0004054 ! inheres in internal male genitalia [Term] id: OBA:0004649 @@ -143791,7 +243145,7 @@ synonym: "size of internal male genitalia" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004647 ! internal male genitalia morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004054 ! internal male genitalia +intersection_of: RO:0000052 UBERON:0004054 ! inheres in internal male genitalia [Term] id: OBA:0004650 @@ -143801,8 +243155,8 @@ synonym: "morphology of female reproductive organ" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003134 ! female reproductive organ -relationship: inheres_in UBERON:0003134 ! female reproductive organ +intersection_of: RO:0000052 UBERON:0003134 ! inheres in female reproductive organ +relationship: RO:0000052 UBERON:0003134 ! inheres in female reproductive organ [Term] id: OBA:0004651 @@ -143811,8 +243165,8 @@ def: "The morphology of a internal female genitalia." [AUTO:patterns/patterns/en synonym: "morphology of internal female genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004650 ! female reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003975 ! internal female genitalia -relationship: inheres_in UBERON:0003975 ! internal female genitalia +intersection_of: RO:0000052 UBERON:0003975 ! inheres in internal female genitalia +relationship: RO:0000052 UBERON:0003975 ! inheres in internal female genitalia [Term] id: OBA:0004652 @@ -143821,8 +243175,8 @@ def: "The amount of a internal female genitalia." [AUTO:patterns/patterns/entity synonym: "amount of internal female genitalia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002851 ! internal genitalia amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003975 ! internal female genitalia -relationship: inheres_in UBERON:0003975 ! internal female genitalia +intersection_of: RO:0000052 UBERON:0003975 ! inheres in internal female genitalia +relationship: RO:0000052 UBERON:0003975 ! inheres in internal female genitalia [Term] id: OBA:0004653 @@ -143832,8 +243186,8 @@ synonym: "amount of mammalian vulva" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000997 ! mammalian vulva -relationship: inheres_in UBERON:0000997 ! mammalian vulva +intersection_of: RO:0000052 UBERON:0000997 ! inheres in mammalian vulva +relationship: RO:0000052 UBERON:0000997 ! inheres in mammalian vulva [Term] id: OBA:0004654 @@ -143843,8 +243197,8 @@ synonym: "amount of inguinal canal" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003702 ! inguinal canal -relationship: inheres_in UBERON:0003702 ! inguinal canal +intersection_of: RO:0000052 UBERON:0003702 ! inheres in inguinal canal +relationship: RO:0000052 UBERON:0003702 ! inheres in inguinal canal [Term] id: OBA:0004655 @@ -143854,7 +243208,7 @@ synonym: "size of vas deferens" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0002769 ! vas deferens morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001000 ! vas deferens +intersection_of: RO:0000052 UBERON:0001000 ! inheres in vas deferens [Term] id: OBA:0004656 @@ -143864,8 +243218,8 @@ synonym: "amount of uterine horn" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002247 ! uterine horn -relationship: inheres_in UBERON:0002247 ! uterine horn +intersection_of: RO:0000052 UBERON:0002247 ! inheres in uterine horn +relationship: RO:0000052 UBERON:0002247 ! inheres in uterine horn [Term] id: OBA:0004657 @@ -143874,8 +243228,8 @@ def: "The morphology of a peritoneal vaginal process." [AUTO:patterns/patterns/e synonym: "morphology of peritoneal vaginal process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010684 ! peritoneum morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005344 ! peritoneal vaginal process -relationship: inheres_in UBERON:0005344 ! peritoneal vaginal process +intersection_of: RO:0000052 UBERON:0005344 ! inheres in peritoneal vaginal process +relationship: RO:0000052 UBERON:0005344 ! inheres in peritoneal vaginal process [Term] id: OBA:0004658 @@ -143885,8 +243239,8 @@ synonym: "amount of peritoneal vaginal process" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005344 ! peritoneal vaginal process -relationship: inheres_in UBERON:0005344 ! peritoneal vaginal process +intersection_of: RO:0000052 UBERON:0005344 ! inheres in peritoneal vaginal process +relationship: RO:0000052 UBERON:0005344 ! inheres in peritoneal vaginal process [Term] id: OBA:0004659 @@ -143896,7 +243250,7 @@ synonym: "amount of endometrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000546 ! endometrium quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001295 ! endometrium +intersection_of: RO:0000052 UBERON:0001295 ! inheres in endometrium [Term] id: OBA:0004660 @@ -143905,8 +243259,8 @@ def: "The morphology of a median eminence of neurohypophysis." [AUTO:patterns/pa synonym: "morphology of median eminence of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005867 ! secretory circumventricular organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002197 ! median eminence of neurohypophysis -relationship: inheres_in UBERON:0002197 ! median eminence of neurohypophysis +intersection_of: RO:0000052 UBERON:0002197 ! inheres in median eminence of neurohypophysis +relationship: RO:0000052 UBERON:0002197 ! inheres in median eminence of neurohypophysis [Term] id: OBA:0004661 @@ -143916,7 +243270,7 @@ synonym: "attachment quality of acrosomal vesicle" EXACT [AUTO:patterns/patterns is_a: OBA:0004526 ! acrosomal vesicle morphology is_a: PATO:0001435 ! attachment quality intersection_of: PATO:0001435 ! attachment quality -intersection_of: inheres_in GO:0001669 ! acrosomal vesicle +intersection_of: RO:0000052 GO:0001669 ! inheres in acrosomal vesicle [Term] id: OBA:0004662 @@ -143926,7 +243280,7 @@ synonym: "shape of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0004523 ! sperm flagellum morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004663 @@ -143936,7 +243290,7 @@ synonym: "coiling of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0004662 ! sperm flagellum shape is_a: PATO:0001794 ! coiling intersection_of: PATO:0001794 ! coiling -intersection_of: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004664 @@ -143946,7 +243300,7 @@ synonym: "length of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000006 ! cilium length is_a: OBA:VT0010406 ! sperm flagellum size trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:0004665 @@ -143956,8 +243310,8 @@ synonym: "color saturation of spleen" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:0004666 @@ -143967,8 +243321,8 @@ synonym: "amount of caput epididymis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004358 ! caput epididymis -relationship: inheres_in UBERON:0004358 ! caput epididymis +intersection_of: RO:0000052 UBERON:0004358 ! inheres in caput epididymis +relationship: RO:0000052 UBERON:0004358 ! inheres in caput epididymis [Term] id: OBA:0004667 @@ -143978,7 +243332,7 @@ synonym: "size of caput epididymis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002660 ! caput epididymis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004358 ! caput epididymis +intersection_of: RO:0000052 UBERON:0004358 ! inheres in caput epididymis [Term] id: OBA:0004668 @@ -143988,7 +243342,7 @@ synonym: "size of endometrial gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004607 ! endometrial gland morphology is_a: OBA:VT0000655 ! sex gland size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002451 ! endometrial gland +intersection_of: RO:0000052 UBERON:0002451 ! inheres in endometrial gland [Term] id: OBA:0004669 @@ -143998,8 +243352,8 @@ synonym: "amount of urinary bladder" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001255 ! urinary bladder -relationship: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder +relationship: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:0004670 @@ -144009,7 +243363,7 @@ synonym: "organization quality of islet of Langerhans" EXACT [AUTO:patterns/patt is_a: OBA:VT0005215 ! islet of Langerhans morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0000006 ! islet of Langerhans +intersection_of: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans [Term] id: OBA:0004671 @@ -144019,7 +243373,7 @@ synonym: "size of corpus epididymis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002661 ! corpus epididymis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004359 ! corpus epididymis +intersection_of: RO:0000052 UBERON:0004359 ! inheres in corpus epididymis [Term] id: OBA:0004672 @@ -144029,8 +243383,8 @@ synonym: "structure of saccule duct" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003976 ! saccule duct -relationship: inheres_in UBERON:0003976 ! saccule duct +intersection_of: RO:0000052 UBERON:0003976 ! inheres in saccule duct +relationship: RO:0000052 UBERON:0003976 ! inheres in saccule duct [Term] id: OBA:0004673 @@ -144040,8 +243394,8 @@ synonym: "morphology of utricle duct" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003977 ! utricle duct -relationship: inheres_in UBERON:0003977 ! utricle duct +intersection_of: RO:0000052 UBERON:0003977 ! inheres in utricle duct +relationship: RO:0000052 UBERON:0003977 ! inheres in utricle duct [Term] id: OBA:0004674 @@ -144051,8 +243405,8 @@ synonym: "morphology of utricle valve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003979 ! utricle valve -relationship: inheres_in UBERON:0003979 ! utricle valve +intersection_of: RO:0000052 UBERON:0003979 ! inheres in utricle valve +relationship: RO:0000052 UBERON:0003979 ! inheres in utricle valve [Term] id: OBA:0004675 @@ -144062,8 +243416,8 @@ synonym: "amount of semicircular canal ampulla" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004043 ! semicircular canal ampulla -relationship: inheres_in UBERON:0004043 ! semicircular canal ampulla +intersection_of: RO:0000052 UBERON:0004043 ! inheres in semicircular canal ampulla +relationship: RO:0000052 UBERON:0004043 ! inheres in semicircular canal ampulla [Term] id: OBA:0004676 @@ -144073,8 +243427,8 @@ synonym: "morphology of cerebellum fissure" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003980 ! cerebellum fissure -relationship: inheres_in UBERON:0003980 ! cerebellum fissure +intersection_of: RO:0000052 UBERON:0003980 ! inheres in cerebellum fissure +relationship: RO:0000052 UBERON:0003980 ! inheres in cerebellum fissure [Term] id: OBA:0004677 @@ -144084,8 +243438,8 @@ synonym: "amount of cerebellum fissure" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003980 ! cerebellum fissure -relationship: inheres_in UBERON:0003980 ! cerebellum fissure +intersection_of: RO:0000052 UBERON:0003980 ! inheres in cerebellum fissure +relationship: RO:0000052 UBERON:0003980 ! inheres in cerebellum fissure [Term] id: OBA:0004678 @@ -144095,7 +243449,7 @@ synonym: "length of strand of guard hair" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000934 ! strand of guard hair quality is_a: OBA:VT0000417 ! hair length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0010512 ! strand of guard hair +intersection_of: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair [Term] id: OBA:0004679 @@ -144105,7 +243459,7 @@ synonym: "functionality of bone marrow cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003194 ! cell functionality is_a: OBA:1000764 ! bone marrow cell quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002092 ! bone marrow cell +intersection_of: RO:0000052 CL:0002092 ! inheres in bone marrow cell [Term] id: OBA:0004680 @@ -144140,7 +243494,7 @@ synonym: "amount of hippocampus fimbria" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000914 ! hippocampus fimbria quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002310 ! hippocampus fimbria +intersection_of: RO:0000052 UBERON:0002310 ! inheres in hippocampus fimbria [Term] id: OBA:0004686 @@ -144149,8 +243503,8 @@ def: "The onset quality of a heart looping." [AUTO:patterns/patterns/entity_attr synonym: "onset quality of heart looping" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0001947 ! heart looping -relationship: inheres_in GO:0001947 ! heart looping +intersection_of: RO:0000052 GO:0001947 ! inheres in heart looping +relationship: RO:0000052 GO:0001947 ! inheres in heart looping [Term] id: OBA:0004687 @@ -144160,8 +243514,8 @@ synonym: "morphology of primitive pit" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004055 ! primitive pit -relationship: inheres_in UBERON:0004055 ! primitive pit +intersection_of: RO:0000052 UBERON:0004055 ! inheres in primitive pit +relationship: RO:0000052 UBERON:0004055 ! inheres in primitive pit [Term] id: OBA:0004688 @@ -144171,8 +243525,8 @@ synonym: "morphology of primitive groove" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004056 ! primitive groove -relationship: inheres_in UBERON:0004056 ! primitive groove +intersection_of: RO:0000052 UBERON:0004056 ! inheres in primitive groove +relationship: RO:0000052 UBERON:0004056 ! inheres in primitive groove [Term] id: OBA:0004689 @@ -144182,8 +243536,8 @@ synonym: "amount of primitive knot" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003062 ! primitive knot -relationship: inheres_in UBERON:0003062 ! primitive knot +intersection_of: RO:0000052 UBERON:0003062 ! inheres in primitive knot +relationship: RO:0000052 UBERON:0003062 ! inheres in primitive knot [Term] id: OBA:0004690 @@ -144193,7 +243547,7 @@ synonym: "thickness of trabecular bone tissue" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0004691 ! trabecular bone tissue size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002483 ! trabecular bone tissue +intersection_of: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue [Term] id: OBA:0004691 @@ -144203,7 +243557,7 @@ synonym: "size of trabecular bone tissue" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000130 ! cancellous bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002483 ! trabecular bone tissue +intersection_of: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue [Term] id: OBA:0004692 @@ -144213,7 +243567,7 @@ synonym: "acidity of urine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000056 ! urine trait is_a: PATO:0001842 ! acidity intersection_of: PATO:0001842 ! acidity -intersection_of: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:0004693 @@ -144223,7 +243577,7 @@ synonym: "size of hair shaft" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003809 ! hair shaft morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002074 ! hair shaft +intersection_of: RO:0000052 UBERON:0002074 ! inheres in hair shaft [Term] id: OBA:0004694 @@ -144232,8 +243586,8 @@ def: "The morphology of a primordial ovarian follicle." [AUTO:patterns/patterns/ synonym: "morphology of primordial ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001131 ! ovarian follicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003981 ! primordial ovarian follicle -relationship: inheres_in UBERON:0003981 ! primordial ovarian follicle +intersection_of: RO:0000052 UBERON:0003981 ! inheres in primordial ovarian follicle +relationship: RO:0000052 UBERON:0003981 ! inheres in primordial ovarian follicle [Term] id: OBA:0004695 @@ -144242,8 +243596,8 @@ def: "The morphology of a primary ovarian follicle." [AUTO:patterns/patterns/ent synonym: "morphology of primary ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001131 ! ovarian follicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000035 ! primary ovarian follicle -relationship: inheres_in UBERON:0000035 ! primary ovarian follicle +intersection_of: RO:0000052 UBERON:0000035 ! inheres in primary ovarian follicle +relationship: RO:0000052 UBERON:0000035 ! inheres in primary ovarian follicle [Term] id: OBA:0004696 @@ -144252,8 +243606,8 @@ def: "The morphology of a secondary ovarian follicle." [AUTO:patterns/patterns/e synonym: "morphology of secondary ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001131 ! ovarian follicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000036 ! secondary ovarian follicle -relationship: inheres_in UBERON:0000036 ! secondary ovarian follicle +intersection_of: RO:0000052 UBERON:0000036 ! inheres in secondary ovarian follicle +relationship: RO:0000052 UBERON:0000036 ! inheres in secondary ovarian follicle [Term] id: OBA:0004697 @@ -144262,8 +243616,8 @@ def: "The morphology of a mature ovarian follicle." [AUTO:patterns/patterns/enti synonym: "morphology of mature ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001131 ! ovarian follicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003982 ! mature ovarian follicle -relationship: inheres_in UBERON:0003982 ! mature ovarian follicle +intersection_of: RO:0000052 UBERON:0003982 ! inheres in mature ovarian follicle +relationship: RO:0000052 UBERON:0003982 ! inheres in mature ovarian follicle [Term] id: OBA:0004698 @@ -144273,8 +243627,8 @@ synonym: "morphology of theca cell layer" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000155 ! theca cell layer -relationship: inheres_in UBERON:0000155 ! theca cell layer +intersection_of: RO:0000052 UBERON:0000155 ! inheres in theca cell layer +relationship: RO:0000052 UBERON:0000155 ! inheres in theca cell layer [Term] id: OBA:0004699 @@ -144284,8 +243638,8 @@ synonym: "morphology of theca interna" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000157 ! theca interna -relationship: inheres_in UBERON:0000157 ! theca interna +intersection_of: RO:0000052 UBERON:0000157 ! inheres in theca interna +relationship: RO:0000052 UBERON:0000157 ! inheres in theca interna [Term] id: OBA:0004700 @@ -144295,8 +243649,8 @@ synonym: "morphology of theca externa" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000156 ! theca externa -relationship: inheres_in UBERON:0000156 ! theca externa +intersection_of: RO:0000052 UBERON:0000156 ! inheres in theca externa +relationship: RO:0000052 UBERON:0000156 ! inheres in theca externa [Term] id: OBA:0004701 @@ -144306,8 +243660,8 @@ synonym: "amount of theca cell layer" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000155 ! theca cell layer -relationship: inheres_in UBERON:0000155 ! theca cell layer +intersection_of: RO:0000052 UBERON:0000155 ! inheres in theca cell layer +relationship: RO:0000052 UBERON:0000155 ! inheres in theca cell layer [Term] id: OBA:0004702 @@ -144317,8 +243671,8 @@ synonym: "amount of theca cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000503 ! theca cell -relationship: inheres_in CL:0000503 ! theca cell +intersection_of: RO:0000052 CL:0000503 ! inheres in theca cell +relationship: RO:0000052 CL:0000503 ! inheres in theca cell [Term] id: OBA:0004703 @@ -144328,7 +243682,7 @@ synonym: "amount of ovarian cumulus expansion" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000902 ! ovarian cumulus expansion quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001550 ! ovarian cumulus expansion +intersection_of: RO:0000052 GO:0001550 ! inheres in ovarian cumulus expansion [Term] id: OBA:0004704 @@ -144338,7 +243692,7 @@ synonym: "size of zona pellucida" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003696 ! zona pellucida morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000086 ! zona pellucida +intersection_of: RO:0000052 UBERON:0000086 ! inheres in zona pellucida [Term] id: OBA:0004705 @@ -144348,8 +243702,8 @@ synonym: "morphology of manchette" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0002177 ! manchette -relationship: inheres_in GO:0002177 ! manchette +intersection_of: RO:0000052 GO:0002177 ! inheres in manchette +relationship: RO:0000052 GO:0002177 ! inheres in manchette [Term] id: OBA:0004706 @@ -144359,8 +243713,8 @@ synonym: "displaced of manchette" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in GO:0002177 ! manchette -relationship: inheres_in GO:0002177 ! manchette +intersection_of: RO:0000052 GO:0002177 ! inheres in manchette +relationship: RO:0000052 GO:0002177 ! inheres in manchette [Term] id: OBA:0004707 @@ -144370,8 +243724,8 @@ synonym: "morphology of endoplasmic reticulum" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005783 ! endoplasmic reticulum -relationship: inheres_in GO:0005783 ! endoplasmic reticulum +intersection_of: RO:0000052 GO:0005783 ! inheres in endoplasmic reticulum +relationship: RO:0000052 GO:0005783 ! inheres in endoplasmic reticulum [Term] id: OBA:0004708 @@ -144381,8 +243735,8 @@ synonym: "morphology of prostate gland ventral lobe" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007615 ! prostate gland ventral lobe -relationship: inheres_in UBERON:0007615 ! prostate gland ventral lobe +intersection_of: RO:0000052 UBERON:0007615 ! inheres in prostate gland ventral lobe +relationship: RO:0000052 UBERON:0007615 ! inheres in prostate gland ventral lobe [Term] id: OBA:0004709 @@ -144392,8 +243746,8 @@ synonym: "morphology of prostate gland dorsolateral lobe" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008808 ! prostate gland dorsolateral lobe -relationship: inheres_in UBERON:0008808 ! prostate gland dorsolateral lobe +intersection_of: RO:0000052 UBERON:0008808 ! inheres in prostate gland dorsolateral lobe +relationship: RO:0000052 UBERON:0008808 ! inheres in prostate gland dorsolateral lobe [Term] id: OBA:0004710 @@ -144403,8 +243757,8 @@ synonym: "morphology of cardiac jelly" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003906 ! cardiac jelly -relationship: inheres_in UBERON:0003906 ! cardiac jelly +intersection_of: RO:0000052 UBERON:0003906 ! inheres in cardiac jelly +relationship: RO:0000052 UBERON:0003906 ! inheres in cardiac jelly [Term] id: OBA:0004711 @@ -144413,8 +243767,8 @@ def: "The morphology of a dermal melanocyte." [AUTO:patterns/patterns/entity_att synonym: "morphology of dermal melanocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003749 ! melanocyte morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002482 ! dermal melanocyte -relationship: inheres_in CL:0002482 ! dermal melanocyte +intersection_of: RO:0000052 CL:0002482 ! inheres in dermal melanocyte +relationship: RO:0000052 CL:0002482 ! inheres in dermal melanocyte [Term] id: OBA:0004712 @@ -144424,7 +243778,7 @@ synonym: "length of cell of skeletal muscle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0003399 ! skeletal muscle fiber size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:0004713 @@ -144434,8 +243788,8 @@ synonym: "amount of cell of skeletal muscle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle -relationship: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle +relationship: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:0004714 @@ -144445,7 +243799,7 @@ synonym: "spatial pattern of cell of skeletal muscle" EXACT [AUTO:patterns/patte is_a: OBA:VT0003084 ! skeletal muscle fiber morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:0004715 @@ -144454,8 +243808,8 @@ def: "The morphology of a skeletal muscle fiber triad." [AUTO:patterns/patterns/ synonym: "morphology of skeletal muscle fiber triad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000759 ! skeletal muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004057 ! skeletal muscle fiber triad -relationship: inheres_in UBERON:0004057 ! skeletal muscle fiber triad +intersection_of: RO:0000052 UBERON:0004057 ! inheres in skeletal muscle fiber triad +relationship: RO:0000052 UBERON:0004057 ! inheres in skeletal muscle fiber triad [Term] id: OBA:0004716 @@ -144465,7 +243819,7 @@ synonym: "degeneration of cell of skeletal muscle" EXACT [AUTO:patterns/patterns is_a: OBA:VT0003084 ! skeletal muscle fiber morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:0004717 @@ -144475,7 +243829,7 @@ synonym: "degeneration of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0000759 ! skeletal muscle morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:0004718 @@ -144485,7 +243839,7 @@ synonym: "degeneration of myocardium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005329 ! heart muscle morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:0004719 @@ -144494,8 +243848,8 @@ def: "The size of a cardiac muscle tissue." [AUTO:patterns/patterns/entity_attri synonym: "size of cardiac muscle tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001133 ! cardiac muscle tissue -relationship: inheres_in UBERON:0001133 ! cardiac muscle tissue +intersection_of: RO:0000052 UBERON:0001133 ! inheres in cardiac muscle tissue +relationship: RO:0000052 UBERON:0001133 ! inheres in cardiac muscle tissue [Term] id: OBA:0004720 @@ -144505,8 +243859,8 @@ synonym: "mass of gastrocnemius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001388 ! gastrocnemius -relationship: inheres_in UBERON:0001388 ! gastrocnemius +intersection_of: RO:0000052 UBERON:0001388 ! inheres in gastrocnemius +relationship: RO:0000052 UBERON:0001388 ! inheres in gastrocnemius [Term] id: OBA:0004721 @@ -144515,8 +243869,8 @@ def: "The mass of a extensor digitorum longus." [AUTO:patterns/patterns/entity_a synonym: "mass of extensor digitorum longus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001386 ! extensor digitorum longus -relationship: inheres_in UBERON:0001386 ! extensor digitorum longus +intersection_of: RO:0000052 UBERON:0001386 ! inheres in extensor digitorum longus +relationship: RO:0000052 UBERON:0001386 ! inheres in extensor digitorum longus [Term] id: OBA:0004722 @@ -144526,8 +243880,8 @@ synonym: "mass of soleus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001389 ! soleus muscle -relationship: inheres_in UBERON:0001389 ! soleus muscle +intersection_of: RO:0000052 UBERON:0001389 ! inheres in soleus muscle +relationship: RO:0000052 UBERON:0001389 ! inheres in soleus muscle [Term] id: OBA:0004723 @@ -144537,8 +243891,8 @@ synonym: "mass of tibialis anterior" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001385 ! tibialis anterior -relationship: inheres_in UBERON:0001385 ! tibialis anterior +intersection_of: RO:0000052 UBERON:0001385 ! inheres in tibialis anterior +relationship: RO:0000052 UBERON:0001385 ! inheres in tibialis anterior [Term] id: OBA:0004724 @@ -144548,8 +243902,8 @@ synonym: "mass of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001723 ! tongue -relationship: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue +relationship: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0004725 @@ -144559,7 +243913,7 @@ synonym: "mass of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000069 ! embryo trait is_a: OBA:VT0001259 ! body mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:0004726 @@ -144569,7 +243923,7 @@ synonym: "mass of late embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004725 ! embryo mass is_a: OBA:1000606 ! late embryo quality intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000323 ! late embryo +intersection_of: RO:0000052 UBERON:0000323 ! inheres in late embryo [Term] id: OBA:0004727 @@ -144579,8 +243933,8 @@ synonym: "strength of hindlimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0002103 ! hindlimb -relationship: inheres_in UBERON:0002103 ! hindlimb +intersection_of: RO:0000052 UBERON:0002103 ! inheres in hindlimb +relationship: RO:0000052 UBERON:0002103 ! inheres in hindlimb [Term] id: OBA:0004728 @@ -144590,8 +243944,8 @@ synonym: "functionality of platelet dense granule" EXACT [AUTO:patterns/patterns is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0042827 ! platelet dense granule -relationship: inheres_in GO:0042827 ! platelet dense granule +intersection_of: RO:0000052 GO:0042827 ! inheres in platelet dense granule +relationship: RO:0000052 GO:0042827 ! inheres in platelet dense granule [Term] id: OBA:0004729 @@ -144601,8 +243955,8 @@ synonym: "morphology of pituitary stalk" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002434 ! pituitary stalk -relationship: inheres_in UBERON:0002434 ! pituitary stalk +intersection_of: RO:0000052 UBERON:0002434 ! inheres in pituitary stalk +relationship: RO:0000052 UBERON:0002434 ! inheres in pituitary stalk [Term] id: OBA:0004730 @@ -144612,8 +243966,8 @@ synonym: "morphology of infundibulum of gallbladder" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0015139 ! infundibulum of gallbladder -relationship: inheres_in UBERON:0015139 ! infundibulum of gallbladder +intersection_of: RO:0000052 UBERON:0015139 ! inheres in infundibulum of gallbladder +relationship: RO:0000052 UBERON:0015139 ! inheres in infundibulum of gallbladder [Term] id: OBA:0004731 @@ -144623,8 +243977,8 @@ synonym: "morphology of uterine tube infundibulum" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003984 ! uterine tube infundibulum -relationship: inheres_in UBERON:0003984 ! uterine tube infundibulum +intersection_of: RO:0000052 UBERON:0003984 ! inheres in uterine tube infundibulum +relationship: RO:0000052 UBERON:0003984 ! inheres in uterine tube infundibulum [Term] id: OBA:0004732 @@ -144633,8 +243987,8 @@ def: "The morphology of a magnocellular neurosecretory cell." [AUTO:patterns/pat synonym: "morphology of magnocellular neurosecretory cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0011003 ! magnocellular neurosecretory cell -relationship: inheres_in CL:0011003 ! magnocellular neurosecretory cell +intersection_of: RO:0000052 CL:0011003 ! inheres in magnocellular neurosecretory cell +relationship: RO:0000052 CL:0011003 ! inheres in magnocellular neurosecretory cell [Term] id: OBA:0004733 @@ -144644,7 +243998,7 @@ synonym: "altered number of of magnocellular neurosecretory cell" EXACT [AUTO:pa is_a: OBA:0004732 ! magnocellular neurosecretory cell morphology is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0011003 ! magnocellular neurosecretory cell +intersection_of: RO:0000052 CL:0011003 ! inheres in magnocellular neurosecretory cell [Term] id: OBA:0004734 @@ -144654,7 +244008,7 @@ synonym: "size of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000494 ! cecum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:0004735 @@ -144664,7 +244018,7 @@ synonym: "coiling of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000494 ! cecum morphology trait is_a: PATO:0001794 ! coiling intersection_of: PATO:0001794 ! coiling -intersection_of: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:0004736 @@ -144674,7 +244028,7 @@ synonym: "structure of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000494 ! cecum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:0004737 @@ -144684,7 +244038,7 @@ synonym: "size of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002581 ! ileum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:0004738 @@ -144694,7 +244048,7 @@ synonym: "structure of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002581 ! ileum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:0004739 @@ -144704,8 +244058,8 @@ synonym: "morphology of blood vessel endothelium" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004638 ! blood vessel endothelium -relationship: inheres_in UBERON:0004638 ! blood vessel endothelium +intersection_of: RO:0000052 UBERON:0004638 ! inheres in blood vessel endothelium +relationship: RO:0000052 UBERON:0004638 ! inheres in blood vessel endothelium [Term] id: OBA:0004740 @@ -144715,8 +244069,8 @@ synonym: "morphology of epithelium of gall bladder" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002029 ! epithelium of gall bladder -relationship: inheres_in UBERON:0002029 ! epithelium of gall bladder +intersection_of: RO:0000052 UBERON:0002029 ! inheres in epithelium of gall bladder +relationship: RO:0000052 UBERON:0002029 ! inheres in epithelium of gall bladder [Term] id: OBA:0004741 @@ -144725,8 +244079,8 @@ def: "The morphology of a cystic duct." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of cystic duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004746 ! extrahepatic bile duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001152 ! cystic duct -relationship: inheres_in UBERON:0001152 ! cystic duct +intersection_of: RO:0000052 UBERON:0001152 ! inheres in cystic duct +relationship: RO:0000052 UBERON:0001152 ! inheres in cystic duct [Term] id: OBA:0004742 @@ -144736,8 +244090,8 @@ synonym: "morphology of biliary ductule" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004058 ! biliary ductule -relationship: inheres_in UBERON:0004058 ! biliary ductule +intersection_of: RO:0000052 UBERON:0004058 ! inheres in biliary ductule +relationship: RO:0000052 UBERON:0004058 ! inheres in biliary ductule [Term] id: OBA:0004743 @@ -144747,7 +244101,7 @@ synonym: "morphology of common bile duct" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004746 ! extrahepatic bile duct morphology is_a: OBA:1000523 ! common bile duct quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001174 ! common bile duct +intersection_of: RO:0000052 UBERON:0001174 ! inheres in common bile duct [Term] id: OBA:0004744 @@ -144756,8 +244110,8 @@ def: "The morphology of a common hepatic duct." [AUTO:patterns/patterns/entity_a synonym: "morphology of common hepatic duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004746 ! extrahepatic bile duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001175 ! common hepatic duct -relationship: inheres_in UBERON:0001175 ! common hepatic duct +intersection_of: RO:0000052 UBERON:0001175 ! inheres in common hepatic duct +relationship: RO:0000052 UBERON:0001175 ! inheres in common hepatic duct [Term] id: OBA:0004745 @@ -144767,7 +244121,7 @@ synonym: "morphology of intrahepatic bile duct" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000438 ! intrahepatic bile duct quality is_a: OBA:VT0002928 ! bile duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003704 ! intrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct [Term] id: OBA:0004746 @@ -144776,8 +244130,8 @@ def: "The morphology of a extrahepatic bile duct." [AUTO:patterns/patterns/entit synonym: "morphology of extrahepatic bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002928 ! bile duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003703 ! extrahepatic bile duct -relationship: inheres_in UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003703 ! inheres in extrahepatic bile duct +relationship: RO:0000052 UBERON:0003703 ! inheres in extrahepatic bile duct [Term] id: OBA:0004747 @@ -144786,8 +244140,8 @@ def: "The morphology of a intralobular bile duct." [AUTO:patterns/patterns/entit synonym: "morphology of intralobular bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004745 ! intrahepatic bile duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001282 ! intralobular bile duct -relationship: inheres_in UBERON:0001282 ! intralobular bile duct +intersection_of: RO:0000052 UBERON:0001282 ! inheres in intralobular bile duct +relationship: RO:0000052 UBERON:0001282 ! inheres in intralobular bile duct [Term] id: OBA:0004748 @@ -144796,8 +244150,8 @@ def: "The morphology of a interlobular bile duct." [AUTO:patterns/patterns/entit synonym: "morphology of interlobular bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004745 ! intrahepatic bile duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001246 ! interlobular bile duct -relationship: inheres_in UBERON:0001246 ! interlobular bile duct +intersection_of: RO:0000052 UBERON:0001246 ! inheres in interlobular bile duct +relationship: RO:0000052 UBERON:0001246 ! inheres in interlobular bile duct [Term] id: OBA:0004749 @@ -144806,8 +244160,8 @@ def: "The morphology of a hepatic duct." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of hepatic duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002928 ! bile duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005171 ! hepatic duct -relationship: inheres_in UBERON:0005171 ! hepatic duct +intersection_of: RO:0000052 UBERON:0005171 ! inheres in hepatic duct +relationship: RO:0000052 UBERON:0005171 ! inheres in hepatic duct [Term] id: OBA:0004750 @@ -144817,8 +244171,8 @@ synonym: "morphology of epithelium of mammary gland" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003244 ! epithelium of mammary gland -relationship: inheres_in UBERON:0003244 ! epithelium of mammary gland +intersection_of: RO:0000052 UBERON:0003244 ! inheres in epithelium of mammary gland +relationship: RO:0000052 UBERON:0003244 ! inheres in epithelium of mammary gland [Term] id: OBA:0004751 @@ -144828,8 +244182,8 @@ synonym: "morphology of lobule of mammary gland" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001912 ! lobule of mammary gland -relationship: inheres_in UBERON:0001912 ! lobule of mammary gland +intersection_of: RO:0000052 UBERON:0001912 ! inheres in lobule of mammary gland +relationship: RO:0000052 UBERON:0001912 ! inheres in lobule of mammary gland [Term] id: OBA:0004752 @@ -144838,8 +244192,8 @@ def: "The morphology of a mammary gland connective tissue." [AUTO:patterns/patte synonym: "morphology of mammary gland connective tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003584 ! mammary gland connective tissue -relationship: inheres_in UBERON:0003584 ! mammary gland connective tissue +intersection_of: RO:0000052 UBERON:0003584 ! inheres in mammary gland connective tissue +relationship: RO:0000052 UBERON:0003584 ! inheres in mammary gland connective tissue [Term] id: OBA:0004753 @@ -144849,8 +244203,8 @@ synonym: "amount of rectum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001052 ! rectum -relationship: inheres_in UBERON:0001052 ! rectum +intersection_of: RO:0000052 UBERON:0001052 ! inheres in rectum +relationship: RO:0000052 UBERON:0001052 ! inheres in rectum [Term] id: OBA:0004754 @@ -144860,7 +244214,7 @@ synonym: "closure of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000494 ! cecum morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:0004755 @@ -144868,10 +244222,10 @@ name: cerebellar Golgi cell morphology def: "The morphology of a cerebellar Golgi cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of cerebellar Golgi cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003798 ! GABAergic neuron morphology -is_a: OBA:VT0006004 ! interneuron morphology trait +is_a: OBA:VT0004101 ! brain interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000119 ! cerebellar Golgi cell -relationship: inheres_in CL:0000119 ! cerebellar Golgi cell +intersection_of: RO:0000052 CL:0000119 ! inheres in cerebellar Golgi cell +relationship: RO:0000052 CL:0000119 ! inheres in cerebellar Golgi cell [Term] id: OBA:0004756 @@ -144881,8 +244235,8 @@ synonym: "morphology of anterior lingual gland" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0003791 ! minor salivary gland morphology trait is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006330 ! anterior lingual gland -relationship: inheres_in UBERON:0006330 ! anterior lingual gland +intersection_of: RO:0000052 UBERON:0006330 ! inheres in anterior lingual gland +relationship: RO:0000052 UBERON:0006330 ! inheres in anterior lingual gland [Term] id: OBA:0004757 @@ -144891,8 +244245,8 @@ def: "The morphology of a anterior buccal gland." [AUTO:patterns/patterns/entity synonym: "morphology of anterior buccal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000613 ! salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010242 ! anterior buccal gland -relationship: inheres_in UBERON:0010242 ! anterior buccal gland +intersection_of: RO:0000052 UBERON:0010242 ! inheres in anterior buccal gland +relationship: RO:0000052 UBERON:0010242 ! inheres in anterior buccal gland [Term] id: OBA:0004758 @@ -144902,7 +244256,7 @@ synonym: "size of submandibular gland" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003529 ! saliva-secreting gland size is_a: OBA:VT0003793 ! submandibular gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001736 ! submandibular gland +intersection_of: RO:0000052 UBERON:0001736 ! inheres in submandibular gland [Term] id: OBA:0004759 @@ -144912,8 +244266,8 @@ synonym: "amount of submandibular gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001736 ! submandibular gland -relationship: inheres_in UBERON:0001736 ! submandibular gland +intersection_of: RO:0000052 UBERON:0001736 ! inheres in submandibular gland +relationship: RO:0000052 UBERON:0001736 ! inheres in submandibular gland [Term] id: OBA:0004760 @@ -144922,8 +244276,8 @@ def: "The morphology of a submandibular duct." [AUTO:patterns/patterns/entity_at synonym: "morphology of submandibular duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000620 ! salivary duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002334 ! submandibular duct -relationship: inheres_in UBERON:0002334 ! submandibular duct +intersection_of: RO:0000052 UBERON:0002334 ! inheres in submandibular duct +relationship: RO:0000052 UBERON:0002334 ! inheres in submandibular duct [Term] id: OBA:0004761 @@ -144933,8 +244287,8 @@ synonym: "amount of sublingual gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001832 ! sublingual gland -relationship: inheres_in UBERON:0001832 ! sublingual gland +intersection_of: RO:0000052 UBERON:0001832 ! inheres in sublingual gland +relationship: RO:0000052 UBERON:0001832 ! inheres in sublingual gland [Term] id: OBA:0004762 @@ -144943,8 +244297,8 @@ def: "The morphology of a sublingual duct." [AUTO:patterns/patterns/entity_attri synonym: "morphology of sublingual duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000620 ! salivary duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001838 ! sublingual duct -relationship: inheres_in UBERON:0001838 ! sublingual duct +intersection_of: RO:0000052 UBERON:0001838 ! inheres in sublingual duct +relationship: RO:0000052 UBERON:0001838 ! inheres in sublingual duct [Term] id: OBA:0004763 @@ -144953,8 +244307,8 @@ def: "The morphology of a major sublingual duct." [AUTO:patterns/patterns/entity synonym: "morphology of major sublingual duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004762 ! sublingual duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003985 ! major sublingual duct -relationship: inheres_in UBERON:0003985 ! major sublingual duct +intersection_of: RO:0000052 UBERON:0003985 ! inheres in major sublingual duct +relationship: RO:0000052 UBERON:0003985 ! inheres in major sublingual duct [Term] id: OBA:0004764 @@ -144963,8 +244317,8 @@ def: "The morphology of a minor sublingual duct." [AUTO:patterns/patterns/entity synonym: "morphology of minor sublingual duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004762 ! sublingual duct morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003986 ! minor sublingual duct -relationship: inheres_in UBERON:0003986 ! minor sublingual duct +intersection_of: RO:0000052 UBERON:0003986 ! inheres in minor sublingual duct +relationship: RO:0000052 UBERON:0003986 ! inheres in minor sublingual duct [Term] id: OBA:0004765 @@ -144973,8 +244327,8 @@ def: "The morphology of a parotid main excretory duct." [AUTO:patterns/patterns/ synonym: "morphology of parotid main excretory duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000620 ! salivary duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001065 ! parotid main excretory duct -relationship: inheres_in UBERON:0001065 ! parotid main excretory duct +intersection_of: RO:0000052 UBERON:0001065 ! inheres in parotid main excretory duct +relationship: RO:0000052 UBERON:0001065 ! inheres in parotid main excretory duct [Term] id: OBA:0004766 @@ -144984,7 +244338,7 @@ synonym: "size of parotid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003529 ! saliva-secreting gland size is_a: OBA:VT0003452 ! parotid gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001831 ! parotid gland +intersection_of: RO:0000052 UBERON:0001831 ! inheres in parotid gland [Term] id: OBA:0004767 @@ -144993,8 +244347,8 @@ def: "The amount of a palatine gland." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of palatine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005250 ! minor salivary gland amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002447 ! palatine gland -relationship: inheres_in UBERON:0002447 ! palatine gland +intersection_of: RO:0000052 UBERON:0002447 ! inheres in palatine gland +relationship: RO:0000052 UBERON:0002447 ! inheres in palatine gland [Term] id: OBA:0004768 @@ -145003,8 +244357,8 @@ def: "The amount of a anterior lingual gland." [AUTO:patterns/patterns/entity_at synonym: "amount of anterior lingual gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005250 ! minor salivary gland amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006330 ! anterior lingual gland -relationship: inheres_in UBERON:0006330 ! anterior lingual gland +intersection_of: RO:0000052 UBERON:0006330 ! inheres in anterior lingual gland +relationship: RO:0000052 UBERON:0006330 ! inheres in anterior lingual gland [Term] id: OBA:0004769 @@ -145013,8 +244367,8 @@ def: "The morphology of a skin sebaceous gland." [AUTO:patterns/patterns/entity_ synonym: "morphology of skin sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000647 ! sebaceous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003487 ! skin sebaceous gland -relationship: inheres_in UBERON:0003487 ! skin sebaceous gland +intersection_of: RO:0000052 UBERON:0003487 ! inheres in skin sebaceous gland +relationship: RO:0000052 UBERON:0003487 ! inheres in skin sebaceous gland [Term] id: OBA:0004770 @@ -145023,8 +244377,8 @@ def: "The morphology of a interstitial cell of Cajal." [AUTO:patterns/patterns/e synonym: "morphology of interstitial cell of Cajal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002088 ! interstitial cell of Cajal -relationship: inheres_in CL:0002088 ! interstitial cell of Cajal +intersection_of: RO:0000052 CL:0002088 ! inheres in interstitial cell of Cajal +relationship: RO:0000052 CL:0002088 ! inheres in interstitial cell of Cajal [Term] id: OBA:0004771 @@ -145034,7 +244388,7 @@ synonym: "size of interstitial cell of Cajal" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000055 ! cell size is_a: OBA:0004770 ! interstitial cell of Cajal morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0002088 ! interstitial cell of Cajal +intersection_of: RO:0000052 CL:0002088 ! inheres in interstitial cell of Cajal [Term] id: OBA:0004772 @@ -145044,8 +244398,8 @@ synonym: "amount of Hassall's corpuscle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003987 ! Hassall's corpuscle -relationship: inheres_in UBERON:0003987 ! Hassall's corpuscle +intersection_of: RO:0000052 UBERON:0003987 ! inheres in Hassall's corpuscle +relationship: RO:0000052 UBERON:0003987 ! inheres in Hassall's corpuscle [Term] id: OBA:0004773 @@ -145054,8 +244408,8 @@ def: "The rate of a thymocyte apoptotic process." [AUTO:patterns/patterns/entity synonym: "rate of thymocyte apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004259 ! T cell apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070242 ! thymocyte apoptotic process -relationship: inheres_in GO:0070242 ! thymocyte apoptotic process +intersection_of: RO:0000052 GO:0070242 ! inheres in thymocyte apoptotic process +relationship: RO:0000052 GO:0070242 ! inheres in thymocyte apoptotic process [Term] id: OBA:0004774 @@ -145065,8 +244419,8 @@ synonym: "amount of stratum granulosum of epidermis" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002069 ! stratum granulosum of epidermis -relationship: inheres_in UBERON:0002069 ! stratum granulosum of epidermis +intersection_of: RO:0000052 UBERON:0002069 ! inheres in stratum granulosum of epidermis +relationship: RO:0000052 UBERON:0002069 ! inheres in stratum granulosum of epidermis [Term] id: OBA:0004775 @@ -145076,7 +244430,7 @@ synonym: "degeneration of superior cervical ganglion" EXACT [AUTO:patterns/patte is_a: OBA:VT0001011 ! superior cervical ganglion morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001989 ! superior cervical ganglion +intersection_of: RO:0000052 UBERON:0001989 ! inheres in superior cervical ganglion [Term] id: OBA:0004776 @@ -145085,8 +244439,8 @@ def: "The morphology of a left lung." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of left lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001175 ! lung morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002168 ! left lung -relationship: inheres_in UBERON:0002168 ! left lung +intersection_of: RO:0000052 UBERON:0002168 ! inheres in left lung +relationship: RO:0000052 UBERON:0002168 ! inheres in left lung [Term] id: OBA:0004777 @@ -145095,8 +244449,8 @@ def: "The morphology of a right lung." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of right lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001175 ! lung morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002167 ! right lung -relationship: inheres_in UBERON:0002167 ! right lung +intersection_of: RO:0000052 UBERON:0002167 ! inheres in right lung +relationship: RO:0000052 UBERON:0002167 ! inheres in right lung [Term] id: OBA:0004778 @@ -145105,8 +244459,8 @@ def: "The morphology of a right lung accessory lobe." [AUTO:patterns/patterns/en synonym: "morphology of right lung accessory lobe" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005289 ! lobe of lung morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004890 ! right lung accessory lobe -relationship: inheres_in UBERON:0004890 ! right lung accessory lobe +intersection_of: RO:0000052 UBERON:0004890 ! inheres in right lung accessory lobe +relationship: RO:0000052 UBERON:0004890 ! inheres in right lung accessory lobe [Term] id: OBA:0004779 @@ -145115,8 +244469,8 @@ def: "The morphology of a upper lobe of right lung." [AUTO:patterns/patterns/ent synonym: "morphology of upper lobe of right lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005289 ! lobe of lung morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002170 ! upper lobe of right lung -relationship: inheres_in UBERON:0002170 ! upper lobe of right lung +intersection_of: RO:0000052 UBERON:0002170 ! inheres in upper lobe of right lung +relationship: RO:0000052 UBERON:0002170 ! inheres in upper lobe of right lung [Term] id: OBA:0004780 @@ -145125,8 +244479,8 @@ def: "The morphology of a middle lobe of right lung." [AUTO:patterns/patterns/en synonym: "morphology of middle lobe of right lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005289 ! lobe of lung morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002174 ! middle lobe of right lung -relationship: inheres_in UBERON:0002174 ! middle lobe of right lung +intersection_of: RO:0000052 UBERON:0002174 ! inheres in middle lobe of right lung +relationship: RO:0000052 UBERON:0002174 ! inheres in middle lobe of right lung [Term] id: OBA:0004781 @@ -145135,8 +244489,8 @@ def: "The morphology of a lower lobe of right lung." [AUTO:patterns/patterns/ent synonym: "morphology of lower lobe of right lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005289 ! lobe of lung morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002171 ! lower lobe of right lung -relationship: inheres_in UBERON:0002171 ! lower lobe of right lung +intersection_of: RO:0000052 UBERON:0002171 ! inheres in lower lobe of right lung +relationship: RO:0000052 UBERON:0002171 ! inheres in lower lobe of right lung [Term] id: OBA:0004782 @@ -145145,8 +244499,8 @@ def: "The morphology of a pubic symphysis." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pubic symphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003754 ! skeletal joint morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003699 ! pubic symphysis -relationship: inheres_in UBERON:0003699 ! pubic symphysis +intersection_of: RO:0000052 UBERON:0003699 ! inheres in pubic symphysis +relationship: RO:0000052 UBERON:0003699 ! inheres in pubic symphysis [Term] id: OBA:0004783 @@ -145156,7 +244510,7 @@ synonym: "amount of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005382 ! head trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:0004784 @@ -145166,7 +244520,7 @@ synonym: "rate of keratinocyte apoptotic process" EXACT [AUTO:patterns/patterns/ is_a: OBA:0004174 ! apoptotic process rate is_a: OBA:1000750 ! keratinocyte apoptotic process quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0097283 ! keratinocyte apoptotic process +intersection_of: RO:0000052 GO:0097283 ! inheres in keratinocyte apoptotic process [Term] id: OBA:0004785 @@ -145175,8 +244529,8 @@ def: "The rate of a keratinocyte proliferation." [AUTO:patterns/patterns/entity_ synonym: "rate of keratinocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0043616 ! keratinocyte proliferation -relationship: inheres_in GO:0043616 ! keratinocyte proliferation +intersection_of: RO:0000052 GO:0043616 ! inheres in keratinocyte proliferation +relationship: RO:0000052 GO:0043616 ! inheres in keratinocyte proliferation [Term] id: OBA:0004786 @@ -145186,8 +244540,8 @@ synonym: "displaced of bone element" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:0004787 @@ -145197,8 +244551,8 @@ synonym: "amount of chorion membrane" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003124 ! chorion membrane -relationship: inheres_in UBERON:0003124 ! chorion membrane +intersection_of: RO:0000052 UBERON:0003124 ! inheres in chorion membrane +relationship: RO:0000052 UBERON:0003124 ! inheres in chorion membrane [Term] id: OBA:0004788 @@ -145207,8 +244561,8 @@ def: "The morphology of a cornified envelope." [AUTO:patterns/patterns/entity_at synonym: "morphology of cornified envelope" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000089 ! plasma membrane morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0001533 ! cornified envelope -relationship: inheres_in GO:0001533 ! cornified envelope +intersection_of: RO:0000052 GO:0001533 ! inheres in cornified envelope +relationship: RO:0000052 GO:0001533 ! inheres in cornified envelope [Term] id: OBA:0004789 @@ -145218,7 +244572,7 @@ synonym: "size of cornified envelope" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000057 ! cellular component size is_a: OBA:0004788 ! cornified envelope morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0001533 ! cornified envelope +intersection_of: RO:0000052 GO:0001533 ! inheres in cornified envelope [Term] id: OBA:0004790 @@ -145228,7 +244582,7 @@ synonym: "size of stratum granulosum of epidermis" EXACT [AUTO:patterns/patterns is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001239 ! epidermis stratum granulosum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002069 ! stratum granulosum of epidermis +intersection_of: RO:0000052 UBERON:0002069 ! inheres in stratum granulosum of epidermis [Term] id: OBA:0004791 @@ -145238,8 +244592,8 @@ synonym: "amount of basioccipital bone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001692 ! basioccipital bone -relationship: inheres_in UBERON:0001692 ! basioccipital bone +intersection_of: RO:0000052 UBERON:0001692 ! inheres in basioccipital bone +relationship: RO:0000052 UBERON:0001692 ! inheres in basioccipital bone [Term] id: OBA:0004792 @@ -145249,7 +244603,7 @@ synonym: "size of epidermis suprabasal layer" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0003622 ! epidermis suprabasal layer morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010402 ! epidermis suprabasal layer +intersection_of: RO:0000052 UBERON:0010402 ! inheres in epidermis suprabasal layer [Term] id: OBA:0004793 @@ -145259,8 +244613,8 @@ synonym: "amount of stratum spinosum of epidermis" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002026 ! stratum spinosum of epidermis -relationship: inheres_in UBERON:0002026 ! stratum spinosum of epidermis +intersection_of: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis +relationship: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis [Term] id: OBA:0004794 @@ -145270,8 +244624,8 @@ synonym: "morphology of primary vitreous" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005746 ! primary vitreous -relationship: inheres_in UBERON:0005746 ! primary vitreous +intersection_of: RO:0000052 UBERON:0005746 ! inheres in primary vitreous +relationship: RO:0000052 UBERON:0005746 ! inheres in primary vitreous [Term] id: OBA:0004795 @@ -145281,7 +244635,7 @@ synonym: "size of primary vitreous" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004794 ! primary vitreous morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005746 ! primary vitreous +intersection_of: RO:0000052 UBERON:0005746 ! inheres in primary vitreous [Term] id: OBA:0004796 @@ -145290,8 +244644,8 @@ def: "The amount of a inguinal lymph node." [AUTO:patterns/patterns/entity_attri synonym: "amount of inguinal lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004424 ! peripheral lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001542 ! inguinal lymph node -relationship: inheres_in UBERON:0001542 ! inguinal lymph node +intersection_of: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node +relationship: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node [Term] id: OBA:0004797 @@ -145300,8 +244654,8 @@ def: "The amount of a brachial lymph node." [AUTO:patterns/patterns/entity_attri synonym: "amount of brachial lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003538 ! lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002525 ! brachial lymph node -relationship: inheres_in UBERON:0002525 ! brachial lymph node +intersection_of: RO:0000052 UBERON:0002525 ! inheres in brachial lymph node +relationship: RO:0000052 UBERON:0002525 ! inheres in brachial lymph node [Term] id: OBA:0004798 @@ -145310,8 +244664,8 @@ def: "The amount of a axillary lymph node." [AUTO:patterns/patterns/entity_attri synonym: "amount of axillary lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004424 ! peripheral lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001097 ! axillary lymph node -relationship: inheres_in UBERON:0001097 ! axillary lymph node +intersection_of: RO:0000052 UBERON:0001097 ! inheres in axillary lymph node +relationship: RO:0000052 UBERON:0001097 ! inheres in axillary lymph node [Term] id: OBA:0004799 @@ -145320,8 +244674,8 @@ def: "The amount of a cervical lymph node." [AUTO:patterns/patterns/entity_attri synonym: "amount of cervical lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003538 ! lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002429 ! cervical lymph node -relationship: inheres_in UBERON:0002429 ! cervical lymph node +intersection_of: RO:0000052 UBERON:0002429 ! inheres in cervical lymph node +relationship: RO:0000052 UBERON:0002429 ! inheres in cervical lymph node [Term] id: OBA:0004800 @@ -145330,8 +244684,8 @@ def: "The amount of a popliteal lymph node." [AUTO:patterns/patterns/entity_attr synonym: "amount of popliteal lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004424 ! peripheral lymph node amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001543 ! popliteal lymph node -relationship: inheres_in UBERON:0001543 ! popliteal lymph node +intersection_of: RO:0000052 UBERON:0001543 ! inheres in popliteal lymph node +relationship: RO:0000052 UBERON:0001543 ! inheres in popliteal lymph node [Term] id: OBA:0004801 @@ -145341,8 +244695,8 @@ synonym: "morphology of pretectal region" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001944 ! pretectal region -relationship: inheres_in UBERON:0001944 ! pretectal region +intersection_of: RO:0000052 UBERON:0001944 ! inheres in pretectal region +relationship: RO:0000052 UBERON:0001944 ! inheres in pretectal region [Term] id: OBA:0004802 @@ -145352,8 +244706,8 @@ synonym: "morphology of olivary pretectal nucleus" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002565 ! olivary pretectal nucleus -relationship: inheres_in UBERON:0002565 ! olivary pretectal nucleus +intersection_of: RO:0000052 UBERON:0002565 ! inheres in olivary pretectal nucleus +relationship: RO:0000052 UBERON:0002565 ! inheres in olivary pretectal nucleus [Term] id: OBA:0004803 @@ -145362,8 +244716,8 @@ def: "The morphology of a nephron tubule epithelium." [AUTO:patterns/patterns/en synonym: "morphology of nephron tubule epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004810 ! nephron tubule epithelium -relationship: inheres_in UBERON:0004810 ! nephron tubule epithelium +intersection_of: RO:0000052 UBERON:0004810 ! inheres in nephron tubule epithelium +relationship: RO:0000052 UBERON:0004810 ! inheres in nephron tubule epithelium [Term] id: OBA:0004804 @@ -145373,7 +244727,7 @@ synonym: "degeneration of kidney" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002000 ! kidney structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:0004805 @@ -145383,7 +244737,7 @@ synonym: "frequency of fertilization" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003462 ! fertilization rate is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency -intersection_of: inheres_in GO:0009566 ! fertilization +intersection_of: RO:0000052 GO:0009566 ! inheres in fertilization [Term] id: OBA:0004806 @@ -145393,7 +244747,7 @@ synonym: "onset quality of embryo implantation" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0001727 ! embryo implantation trait is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007566 ! embryo implantation +intersection_of: RO:0000052 GO:0007566 ! inheres in embryo implantation [Term] id: OBA:0004807 @@ -145403,8 +244757,8 @@ synonym: "morphology of transverse palatine fold" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008799 ! transverse palatine fold -relationship: inheres_in UBERON:0008799 ! transverse palatine fold +intersection_of: RO:0000052 UBERON:0008799 ! inheres in transverse palatine fold +relationship: RO:0000052 UBERON:0008799 ! inheres in transverse palatine fold [Term] id: OBA:0004808 @@ -145414,7 +244768,7 @@ synonym: "shape of coat of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003645 ! coat of hair morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair [Term] id: OBA:0004809 @@ -145424,8 +244778,8 @@ synonym: "functionality of uterus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000995 ! uterus -relationship: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus +relationship: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:0004810 @@ -145435,8 +244789,8 @@ synonym: "morphology of spinal cord lateral column" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005374 ! spinal cord lateral column -relationship: inheres_in UBERON:0005374 ! spinal cord lateral column +intersection_of: RO:0000052 UBERON:0005374 ! inheres in spinal cord lateral column +relationship: RO:0000052 UBERON:0005374 ! inheres in spinal cord lateral column [Term] id: OBA:0004811 @@ -145446,8 +244800,8 @@ synonym: "morphology of spinal cord ventral column" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005375 ! spinal cord ventral column -relationship: inheres_in UBERON:0005375 ! spinal cord ventral column +intersection_of: RO:0000052 UBERON:0005375 ! inheres in spinal cord ventral column +relationship: RO:0000052 UBERON:0005375 ! inheres in spinal cord ventral column [Term] id: OBA:0004812 @@ -145457,8 +244811,8 @@ synonym: "morphology of medulla oblongata anterior median fissure" EXACT [AUTO:p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003989 ! medulla oblongata anterior median fissure -relationship: inheres_in UBERON:0003989 ! medulla oblongata anterior median fissure +intersection_of: RO:0000052 UBERON:0003989 ! inheres in medulla oblongata anterior median fissure +relationship: RO:0000052 UBERON:0003989 ! inheres in medulla oblongata anterior median fissure [Term] id: OBA:0004813 @@ -145468,8 +244822,8 @@ synonym: "morphology of pyramidal decussation" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002755 ! pyramidal decussation -relationship: inheres_in UBERON:0002755 ! pyramidal decussation +intersection_of: RO:0000052 UBERON:0002755 ! inheres in pyramidal decussation +relationship: RO:0000052 UBERON:0002755 ! inheres in pyramidal decussation [Term] id: OBA:0004814 @@ -145478,8 +244832,8 @@ def: "The morphology of a ventral corticospinal tract." [AUTO:patterns/patterns/ synonym: "morphology of ventral corticospinal tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002760 ! ventral corticospinal tract -relationship: inheres_in UBERON:0002760 ! ventral corticospinal tract +intersection_of: RO:0000052 UBERON:0002760 ! inheres in ventral corticospinal tract +relationship: RO:0000052 UBERON:0002760 ! inheres in ventral corticospinal tract [Term] id: OBA:0004815 @@ -145488,8 +244842,8 @@ def: "The morphology of a lateral corticospinal tract." [AUTO:patterns/patterns/ synonym: "morphology of lateral corticospinal tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002589 ! lateral corticospinal tract -relationship: inheres_in UBERON:0002589 ! lateral corticospinal tract +intersection_of: RO:0000052 UBERON:0002589 ! inheres in lateral corticospinal tract +relationship: RO:0000052 UBERON:0002589 ! inheres in lateral corticospinal tract [Term] id: OBA:0004816 @@ -145499,8 +244853,8 @@ synonym: "morphology of spinal cord lateral motor column" EXACT [AUTO:patterns/p is_a: OBA:0004810 ! spinal cord lateral column morphology is_a: OBA:0004817 ! spinal cord motor column morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010405 ! spinal cord lateral motor column -relationship: inheres_in UBERON:0010405 ! spinal cord lateral motor column +intersection_of: RO:0000052 UBERON:0010405 ! inheres in spinal cord lateral motor column +relationship: RO:0000052 UBERON:0010405 ! inheres in spinal cord lateral motor column [Term] id: OBA:0004817 @@ -145510,8 +244864,8 @@ synonym: "morphology of spinal cord motor column" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003990 ! spinal cord motor column -relationship: inheres_in UBERON:0003990 ! spinal cord motor column +intersection_of: RO:0000052 UBERON:0003990 ! inheres in spinal cord motor column +relationship: RO:0000052 UBERON:0003990 ! inheres in spinal cord motor column [Term] id: OBA:0004818 @@ -145520,8 +244874,8 @@ def: "The morphology of a spinal cord medial motor column." [AUTO:patterns/patte synonym: "morphology of spinal cord medial motor column" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004817 ! spinal cord motor column morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004059 ! spinal cord medial motor column -relationship: inheres_in UBERON:0004059 ! spinal cord medial motor column +intersection_of: RO:0000052 UBERON:0004059 ! inheres in spinal cord medial motor column +relationship: RO:0000052 UBERON:0004059 ! inheres in spinal cord medial motor column [Term] id: OBA:0004819 @@ -145531,8 +244885,8 @@ synonym: "morphology of central canal of spinal cord" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002291 ! central canal of spinal cord -relationship: inheres_in UBERON:0002291 ! central canal of spinal cord +intersection_of: RO:0000052 UBERON:0002291 ! inheres in central canal of spinal cord +relationship: RO:0000052 UBERON:0002291 ! inheres in central canal of spinal cord [Term] id: OBA:0004820 @@ -145541,8 +244895,8 @@ def: "The morphology of a neural tube ventricular layer." [AUTO:patterns/pattern synonym: "morphology of neural tube ventricular layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004060 ! neural tube ventricular layer -relationship: inheres_in UBERON:0004060 ! neural tube ventricular layer +intersection_of: RO:0000052 UBERON:0004060 ! inheres in neural tube ventricular layer +relationship: RO:0000052 UBERON:0004060 ! inheres in neural tube ventricular layer [Term] id: OBA:0004821 @@ -145551,8 +244905,8 @@ def: "The morphology of a neural tube mantle layer." [AUTO:patterns/patterns/ent synonym: "morphology of neural tube mantle layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004061 ! neural tube mantle layer -relationship: inheres_in UBERON:0004061 ! neural tube mantle layer +intersection_of: RO:0000052 UBERON:0004061 ! inheres in neural tube mantle layer +relationship: RO:0000052 UBERON:0004061 ! inheres in neural tube mantle layer [Term] id: OBA:0004822 @@ -145562,8 +244916,8 @@ synonym: "morphology of neural tube marginal layer" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004062 ! neural tube marginal layer -relationship: inheres_in UBERON:0004062 ! neural tube marginal layer +intersection_of: RO:0000052 UBERON:0004062 ! inheres in neural tube marginal layer +relationship: RO:0000052 UBERON:0004062 ! inheres in neural tube marginal layer [Term] id: OBA:0004823 @@ -145573,8 +244927,8 @@ synonym: "morphology of spinal cord alar plate" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004063 ! spinal cord alar plate -relationship: inheres_in UBERON:0004063 ! spinal cord alar plate +intersection_of: RO:0000052 UBERON:0004063 ! inheres in spinal cord alar plate +relationship: RO:0000052 UBERON:0004063 ! inheres in spinal cord alar plate [Term] id: OBA:0004824 @@ -145583,8 +244937,8 @@ def: "The morphology of a neural tube basal plate." [AUTO:patterns/patterns/enti synonym: "morphology of neural tube basal plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004064 ! neural tube basal plate -relationship: inheres_in UBERON:0004064 ! neural tube basal plate +intersection_of: RO:0000052 UBERON:0004064 ! inheres in neural tube basal plate +relationship: RO:0000052 UBERON:0004064 ! inheres in neural tube basal plate [Term] id: OBA:0004825 @@ -145593,8 +244947,8 @@ def: "The morphology of a spinal cord commissure." [AUTO:patterns/patterns/entit synonym: "morphology of spinal cord commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008882 ! spinal cord commissure -relationship: inheres_in UBERON:0008882 ! spinal cord commissure +intersection_of: RO:0000052 UBERON:0008882 ! inheres in spinal cord commissure +relationship: RO:0000052 UBERON:0008882 ! inheres in spinal cord commissure [Term] id: OBA:0004826 @@ -145603,8 +244957,8 @@ def: "The morphology of a spinal cord ventral commissure." [AUTO:patterns/patter synonym: "morphology of spinal cord ventral commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004825 ! spinal cord commissure morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004170 ! spinal cord ventral commissure -relationship: inheres_in UBERON:0004170 ! spinal cord ventral commissure +intersection_of: RO:0000052 UBERON:0004170 ! inheres in spinal cord ventral commissure +relationship: RO:0000052 UBERON:0004170 ! inheres in spinal cord ventral commissure [Term] id: OBA:0004827 @@ -145614,8 +244968,8 @@ synonym: "morphology of spinal cord gray commissure" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004677 ! spinal cord gray commissure -relationship: inheres_in UBERON:0004677 ! spinal cord gray commissure +intersection_of: RO:0000052 UBERON:0004677 ! inheres in spinal cord gray commissure +relationship: RO:0000052 UBERON:0004677 ! inheres in spinal cord gray commissure [Term] id: OBA:0004828 @@ -145625,8 +244979,8 @@ synonym: "morphology of midgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001045 ! midgut -relationship: inheres_in UBERON:0001045 ! midgut +intersection_of: RO:0000052 UBERON:0001045 ! inheres in midgut +relationship: RO:0000052 UBERON:0001045 ! inheres in midgut [Term] id: OBA:0004829 @@ -145636,8 +244990,8 @@ synonym: "amount of midgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001045 ! midgut -relationship: inheres_in UBERON:0001045 ! midgut +intersection_of: RO:0000052 UBERON:0001045 ! inheres in midgut +relationship: RO:0000052 UBERON:0001045 ! inheres in midgut [Term] id: OBA:0004830 @@ -145647,7 +245001,7 @@ synonym: "amount of external acoustic meatus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000704 ! external acoustic meatus quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001352 ! external acoustic meatus +intersection_of: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus [Term] id: OBA:0004831 @@ -145657,7 +245011,7 @@ synonym: "size of stratum basale of epidermis" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001231 ! epidermis stratum basale morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002025 ! stratum basale of epidermis +intersection_of: RO:0000052 UBERON:0002025 ! inheres in stratum basale of epidermis [Term] id: OBA:0004832 @@ -145666,8 +245020,8 @@ def: "The morphology of a subcommissural organ." [AUTO:patterns/patterns/entity_ synonym: "morphology of subcommissural organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005867 ! secretory circumventricular organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002139 ! subcommissural organ -relationship: inheres_in UBERON:0002139 ! subcommissural organ +intersection_of: RO:0000052 UBERON:0002139 ! inheres in subcommissural organ +relationship: RO:0000052 UBERON:0002139 ! inheres in subcommissural organ [Term] id: OBA:0004833 @@ -145677,8 +245031,8 @@ synonym: "amount of subcommissural organ" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002139 ! subcommissural organ -relationship: inheres_in UBERON:0002139 ! subcommissural organ +intersection_of: RO:0000052 UBERON:0002139 ! inheres in subcommissural organ +relationship: RO:0000052 UBERON:0002139 ! inheres in subcommissural organ [Term] id: OBA:0004834 @@ -145688,7 +245042,7 @@ synonym: "amount of Purkinje cell layer of cerebellar cortex" EXACT [AUTO:patter is_a: OBA:1000783 ! Purkinje cell layer of cerebellar cortex quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002979 ! Purkinje cell layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002979 ! inheres in Purkinje cell layer of cerebellar cortex [Term] id: OBA:0004835 @@ -145698,7 +245052,7 @@ synonym: "spatial pattern of mammary gland" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0000627 ! mammary gland morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:0004836 @@ -145708,8 +245062,8 @@ synonym: "amount of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:0004837 @@ -145719,7 +245073,7 @@ synonym: "displaced of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002336 ! nipple position is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:0004838 @@ -145729,8 +245083,8 @@ synonym: "amount of lens vesicle" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005426 ! lens vesicle -relationship: inheres_in UBERON:0005426 ! lens vesicle +intersection_of: RO:0000052 UBERON:0005426 ! inheres in lens vesicle +relationship: RO:0000052 UBERON:0005426 ! inheres in lens vesicle [Term] id: OBA:0004839 @@ -145740,8 +245094,8 @@ synonym: "morphology of future meninx" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007645 ! future meninx -relationship: inheres_in UBERON:0007645 ! future meninx +intersection_of: RO:0000052 UBERON:0007645 ! inheres in future meninx +relationship: RO:0000052 UBERON:0007645 ! inheres in future meninx [Term] id: OBA:0004840 @@ -145751,7 +245105,7 @@ synonym: "morphology of navicular bone of pes" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002810 ! tarsal bone morphology is_a: OBA:1000189 ! navicular bone of pes quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001451 ! navicular bone of pes +intersection_of: RO:0000052 UBERON:0001451 ! inheres in navicular bone of pes [Term] id: OBA:0004841 @@ -145761,8 +245115,8 @@ synonym: "amount of tarsal skeleton" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009879 ! tarsal skeleton -relationship: inheres_in UBERON:0009879 ! tarsal skeleton +intersection_of: RO:0000052 UBERON:0009879 ! inheres in tarsal skeleton +relationship: RO:0000052 UBERON:0009879 ! inheres in tarsal skeleton [Term] id: OBA:0004842 @@ -145772,8 +245126,8 @@ synonym: "morphology of prostate duct" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002485 ! prostate duct -relationship: inheres_in UBERON:0002485 ! prostate duct +intersection_of: RO:0000052 UBERON:0002485 ! inheres in prostate duct +relationship: RO:0000052 UBERON:0002485 ! inheres in prostate duct [Term] id: OBA:0004843 @@ -145783,7 +245137,7 @@ synonym: "structure of prostate gland" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0001158 ! prostate morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002367 ! prostate gland +intersection_of: RO:0000052 UBERON:0002367 ! inheres in prostate gland [Term] id: OBA:0004844 @@ -145792,8 +245146,8 @@ def: "The size of a prostate gland anterior lobe." [AUTO:patterns/patterns/entit synonym: "size of prostate gland anterior lobe" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001329 ! prostate gland anterior lobe -relationship: inheres_in UBERON:0001329 ! prostate gland anterior lobe +intersection_of: RO:0000052 UBERON:0001329 ! inheres in prostate gland anterior lobe +relationship: RO:0000052 UBERON:0001329 ! inheres in prostate gland anterior lobe [Term] id: OBA:0004845 @@ -145803,8 +245157,8 @@ synonym: "displaced of mammary gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000057 ! gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:0004846 @@ -145814,8 +245168,8 @@ synonym: "morphology of hair follicle bulge" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005975 ! hair follicle bulge -relationship: inheres_in UBERON:0005975 ! hair follicle bulge +intersection_of: RO:0000052 UBERON:0005975 ! inheres in hair follicle bulge +relationship: RO:0000052 UBERON:0005975 ! inheres in hair follicle bulge [Term] id: OBA:0004847 @@ -145825,8 +245179,8 @@ synonym: "deviation (from_normal) of mitotic spindle" EXACT [AUTO:patterns/patte is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in GO:0072686 ! mitotic spindle -relationship: inheres_in GO:0072686 ! mitotic spindle +intersection_of: RO:0000052 GO:0072686 ! inheres in mitotic spindle +relationship: RO:0000052 GO:0072686 ! inheres in mitotic spindle [Term] id: OBA:0004848 @@ -145836,8 +245190,8 @@ synonym: "deviation (from_normal) of meiotic spindle" EXACT [AUTO:patterns/patte is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in GO:0072687 ! meiotic spindle -relationship: inheres_in GO:0072687 ! meiotic spindle +intersection_of: RO:0000052 GO:0072687 ! inheres in meiotic spindle +relationship: RO:0000052 GO:0072687 ! inheres in meiotic spindle [Term] id: OBA:0004849 @@ -145847,8 +245201,8 @@ synonym: "morphology of optic chiasma" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000959 ! optic chiasma -relationship: inheres_in UBERON:0000959 ! optic chiasma +intersection_of: RO:0000052 UBERON:0000959 ! inheres in optic chiasma +relationship: RO:0000052 UBERON:0000959 ! inheres in optic chiasma [Term] id: OBA:0004850 @@ -145858,8 +245212,8 @@ synonym: "amount of optic chiasma" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000959 ! optic chiasma -relationship: inheres_in UBERON:0000959 ! optic chiasma +intersection_of: RO:0000052 UBERON:0000959 ! inheres in optic chiasma +relationship: RO:0000052 UBERON:0000959 ! inheres in optic chiasma [Term] id: OBA:0004851 @@ -145869,8 +245223,8 @@ synonym: "amount of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000966 ! retina -relationship: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina +relationship: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:0004852 @@ -145879,8 +245233,8 @@ def: "The functionality of a chondrocyte." [AUTO:patterns/patterns/entity_attrib synonym: "functionality of chondrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000138 ! chondrocyte -relationship: inheres_in CL:0000138 ! chondrocyte +intersection_of: RO:0000052 CL:0000138 ! inheres in chondrocyte +relationship: RO:0000052 CL:0000138 ! inheres in chondrocyte [Term] id: OBA:0004853 @@ -145890,7 +245244,7 @@ synonym: "orientation of basicranium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000249 ! basicranium quality is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002517 ! basicranium +intersection_of: RO:0000052 UBERON:0002517 ! inheres in basicranium [Term] id: OBA:0004854 @@ -145899,8 +245253,8 @@ def: "The morphology of a melanoblast." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of melanoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000541 ! melanoblast -relationship: inheres_in CL:0000541 ! melanoblast +intersection_of: RO:0000052 CL:0000541 ! inheres in melanoblast +relationship: RO:0000052 CL:0000541 ! inheres in melanoblast [Term] id: OBA:0004855 @@ -145910,8 +245264,8 @@ synonym: "morphology of ophthalmic nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000348 ! ophthalmic nerve -relationship: inheres_in UBERON:0000348 ! ophthalmic nerve +intersection_of: RO:0000052 UBERON:0000348 ! inheres in ophthalmic nerve +relationship: RO:0000052 UBERON:0000348 ! inheres in ophthalmic nerve [Term] id: OBA:0004856 @@ -145921,8 +245275,8 @@ synonym: "morphology of maxillary nerve" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000377 ! maxillary nerve -relationship: inheres_in UBERON:0000377 ! maxillary nerve +intersection_of: RO:0000052 UBERON:0000377 ! inheres in maxillary nerve +relationship: RO:0000052 UBERON:0000377 ! inheres in maxillary nerve [Term] id: OBA:0004857 @@ -145932,8 +245286,8 @@ synonym: "morphology of fourth ventricle median aperture" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003991 ! fourth ventricle median aperture -relationship: inheres_in UBERON:0003991 ! fourth ventricle median aperture +intersection_of: RO:0000052 UBERON:0003991 ! inheres in fourth ventricle median aperture +relationship: RO:0000052 UBERON:0003991 ! inheres in fourth ventricle median aperture [Term] id: OBA:0004858 @@ -145943,8 +245297,8 @@ synonym: "morphology of fourth ventricle lateral aperture" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003992 ! fourth ventricle lateral aperture -relationship: inheres_in UBERON:0003992 ! fourth ventricle lateral aperture +intersection_of: RO:0000052 UBERON:0003992 ! inheres in fourth ventricle lateral aperture +relationship: RO:0000052 UBERON:0003992 ! inheres in fourth ventricle lateral aperture [Term] id: OBA:0004859 @@ -145954,8 +245308,8 @@ synonym: "morphology of interventricular foramen of CNS" EXACT [AUTO:patterns/pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003993 ! interventricular foramen of CNS -relationship: inheres_in UBERON:0003993 ! interventricular foramen of CNS +intersection_of: RO:0000052 UBERON:0003993 ! inheres in interventricular foramen of CNS +relationship: RO:0000052 UBERON:0003993 ! inheres in interventricular foramen of CNS [Term] id: OBA:0004860 @@ -145965,8 +245319,8 @@ synonym: "amount of fourth ventricle median aperture" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003991 ! fourth ventricle median aperture -relationship: inheres_in UBERON:0003991 ! fourth ventricle median aperture +intersection_of: RO:0000052 UBERON:0003991 ! inheres in fourth ventricle median aperture +relationship: RO:0000052 UBERON:0003991 ! inheres in fourth ventricle median aperture [Term] id: OBA:0004861 @@ -145975,8 +245329,8 @@ def: "The morphology of a pelvic ligament." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pelvic ligament" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003994 ! pelvic ligament -relationship: inheres_in UBERON:0003994 ! pelvic ligament +intersection_of: RO:0000052 UBERON:0003994 ! inheres in pelvic ligament +relationship: RO:0000052 UBERON:0003994 ! inheres in pelvic ligament [Term] id: OBA:0004862 @@ -145986,7 +245340,7 @@ synonym: "amount of oligodendrocyte" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000238 ! oligodendrocyte quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:0004863 @@ -145996,7 +245350,7 @@ synonym: "size of anterior chamber of eyeball" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005205 ! eye anterior chamber morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001766 ! anterior chamber of eyeball +intersection_of: RO:0000052 UBERON:0001766 ! inheres in anterior chamber of eyeball [Term] id: OBA:0004864 @@ -146006,8 +245360,8 @@ synonym: "morphology of sperm connecting piece" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097224 ! sperm connecting piece -relationship: inheres_in GO:0097224 ! sperm connecting piece +intersection_of: RO:0000052 GO:0097224 ! inheres in sperm connecting piece +relationship: RO:0000052 GO:0097224 ! inheres in sperm connecting piece [Term] id: OBA:0004865 @@ -146017,8 +245371,8 @@ synonym: "morphology of sperm midpiece" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097225 ! sperm midpiece -relationship: inheres_in GO:0097225 ! sperm midpiece +intersection_of: RO:0000052 GO:0097225 ! inheres in sperm midpiece +relationship: RO:0000052 GO:0097225 ! inheres in sperm midpiece [Term] id: OBA:0004866 @@ -146028,8 +245382,8 @@ synonym: "morphology of sperm mitochondrial sheath" EXACT [AUTO:patterns/pattern is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097226 ! sperm mitochondrial sheath -relationship: inheres_in GO:0097226 ! sperm mitochondrial sheath +intersection_of: RO:0000052 GO:0097226 ! inheres in sperm mitochondrial sheath +relationship: RO:0000052 GO:0097226 ! inheres in sperm mitochondrial sheath [Term] id: OBA:0004867 @@ -146039,8 +245393,8 @@ synonym: "morphology of sperm annulus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097227 ! sperm annulus -relationship: inheres_in GO:0097227 ! sperm annulus +intersection_of: RO:0000052 GO:0097227 ! inheres in sperm annulus +relationship: RO:0000052 GO:0097227 ! inheres in sperm annulus [Term] id: OBA:0004868 @@ -146050,8 +245404,8 @@ synonym: "amount of sperm annulus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0097227 ! sperm annulus -relationship: inheres_in GO:0097227 ! sperm annulus +intersection_of: RO:0000052 GO:0097227 ! inheres in sperm annulus +relationship: RO:0000052 GO:0097227 ! inheres in sperm annulus [Term] id: OBA:0004869 @@ -146061,8 +245415,8 @@ synonym: "morphology of sperm principal piece" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097228 ! sperm principal piece -relationship: inheres_in GO:0097228 ! sperm principal piece +intersection_of: RO:0000052 GO:0097228 ! inheres in sperm principal piece +relationship: RO:0000052 GO:0097228 ! inheres in sperm principal piece [Term] id: OBA:0004870 @@ -146072,8 +245426,8 @@ synonym: "morphology of sperm end piece" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097229 ! sperm end piece -relationship: inheres_in GO:0097229 ! sperm end piece +intersection_of: RO:0000052 GO:0097229 ! inheres in sperm end piece +relationship: RO:0000052 GO:0097229 ! inheres in sperm end piece [Term] id: OBA:0004871 @@ -146082,8 +245436,8 @@ def: "The morphology of a foam cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of foam cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000891 ! foam cell -relationship: inheres_in CL:0000891 ! foam cell +intersection_of: RO:0000052 CL:0000891 ! inheres in foam cell +relationship: RO:0000052 CL:0000891 ! inheres in foam cell [Term] id: OBA:0004872 @@ -146093,7 +245447,7 @@ synonym: "altered number of of foam cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004871 ! foam cell morphology is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0000891 ! foam cell +intersection_of: RO:0000052 CL:0000891 ! inheres in foam cell [Term] id: OBA:0004873 @@ -146102,8 +245456,8 @@ def: "The morphology of a migratory neural crest cell." [AUTO:patterns/patterns/ synonym: "morphology of migratory neural crest cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002400 ! multipotent stem cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000333 ! migratory neural crest cell -relationship: inheres_in CL:0000333 ! migratory neural crest cell +intersection_of: RO:0000052 CL:0000333 ! inheres in migratory neural crest cell +relationship: RO:0000052 CL:0000333 ! inheres in migratory neural crest cell [Term] id: OBA:0004874 @@ -146112,8 +245466,8 @@ def: "The morphology of a neural crest." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of neural crest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002342 ! neural crest -relationship: inheres_in UBERON:0002342 ! neural crest +intersection_of: RO:0000052 UBERON:0002342 ! inheres in neural crest +relationship: RO:0000052 UBERON:0002342 ! inheres in neural crest [Term] id: OBA:0004875 @@ -146123,8 +245477,8 @@ synonym: "onset quality of gastric emptying" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0035483 ! gastric emptying -relationship: inheres_in GO:0035483 ! gastric emptying +intersection_of: RO:0000052 GO:0035483 ! inheres in gastric emptying +relationship: RO:0000052 GO:0035483 ! inheres in gastric emptying [Term] id: OBA:0004876 @@ -146134,7 +245488,7 @@ synonym: "amount of cortex of kidney" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000169 ! cortex of kidney quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001225 ! cortex of kidney +intersection_of: RO:0000052 UBERON:0001225 ! inheres in cortex of kidney [Term] id: OBA:0004877 @@ -146144,8 +245498,8 @@ synonym: "opacity of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:0004878 @@ -146154,8 +245508,8 @@ def: "The morphology of a pyloric sphincter." [AUTO:patterns/patterns/entity_att synonym: "morphology of pyloric sphincter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001202 ! pyloric sphincter -relationship: inheres_in UBERON:0001202 ! pyloric sphincter +intersection_of: RO:0000052 UBERON:0001202 ! inheres in pyloric sphincter +relationship: RO:0000052 UBERON:0001202 ! inheres in pyloric sphincter [Term] id: OBA:0004879 @@ -146164,8 +245518,8 @@ def: "The morphology of a heart elastic tissue." [AUTO:patterns/patterns/entity_ synonym: "morphology of heart elastic tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003610 ! heart elastic tissue -relationship: inheres_in UBERON:0003610 ! heart elastic tissue +intersection_of: RO:0000052 UBERON:0003610 ! inheres in heart elastic tissue +relationship: RO:0000052 UBERON:0003610 ! inheres in heart elastic tissue [Term] id: OBA:0004880 @@ -146174,8 +245528,8 @@ def: "The morphology of a aorta endothelium." [AUTO:patterns/patterns/entity_att synonym: "morphology of aorta endothelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004739 ! blood vessel endothelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004851 ! aorta endothelium -relationship: inheres_in UBERON:0004851 ! aorta endothelium +intersection_of: RO:0000052 UBERON:0004851 ! inheres in aorta endothelium +relationship: RO:0000052 UBERON:0004851 ! inheres in aorta endothelium [Term] id: OBA:0004881 @@ -146184,8 +245538,8 @@ def: "The morphology of a aorta smooth muscle tissue." [AUTO:patterns/patterns/e synonym: "morphology of aorta smooth muscle tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005592 ! blood vessel smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004178 ! aorta smooth muscle tissue -relationship: inheres_in UBERON:0004178 ! aorta smooth muscle tissue +intersection_of: RO:0000052 UBERON:0004178 ! inheres in aorta smooth muscle tissue +relationship: RO:0000052 UBERON:0004178 ! inheres in aorta smooth muscle tissue [Term] id: OBA:0004882 @@ -146195,8 +245549,8 @@ synonym: "morphology of aorta wall" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004663 ! aorta wall -relationship: inheres_in UBERON:0004663 ! aorta wall +intersection_of: RO:0000052 UBERON:0004663 ! inheres in aorta wall +relationship: RO:0000052 UBERON:0004663 ! inheres in aorta wall [Term] id: OBA:0004883 @@ -146205,8 +245559,8 @@ def: "The morphology of a ascending aorta." [AUTO:patterns/patterns/entity_attri synonym: "morphology of ascending aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010567 ! thoracic aorta morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001496 ! ascending aorta -relationship: inheres_in UBERON:0001496 ! ascending aorta +intersection_of: RO:0000052 UBERON:0001496 ! inheres in ascending aorta +relationship: RO:0000052 UBERON:0001496 ! inheres in ascending aorta [Term] id: OBA:0004884 @@ -146216,8 +245570,8 @@ synonym: "morphology of descending thoracic aorta" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002345 ! descending thoracic aorta -relationship: inheres_in UBERON:0002345 ! descending thoracic aorta +intersection_of: RO:0000052 UBERON:0002345 ! inheres in descending thoracic aorta +relationship: RO:0000052 UBERON:0002345 ! inheres in descending thoracic aorta [Term] id: OBA:0004885 @@ -146227,8 +245581,8 @@ synonym: "morphology of descending aorta" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001514 ! descending aorta -relationship: inheres_in UBERON:0001514 ! descending aorta +intersection_of: RO:0000052 UBERON:0001514 ! inheres in descending aorta +relationship: RO:0000052 UBERON:0001514 ! inheres in descending aorta [Term] id: OBA:0004886 @@ -146238,8 +245592,8 @@ synonym: "morphology of abdominal aorta" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001516 ! abdominal aorta -relationship: inheres_in UBERON:0001516 ! abdominal aorta +intersection_of: RO:0000052 UBERON:0001516 ! inheres in abdominal aorta +relationship: RO:0000052 UBERON:0001516 ! inheres in abdominal aorta [Term] id: OBA:0004887 @@ -146249,8 +245603,8 @@ synonym: "morphology of aorta tunica adventitia" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004664 ! aorta tunica adventitia -relationship: inheres_in UBERON:0004664 ! aorta tunica adventitia +intersection_of: RO:0000052 UBERON:0004664 ! inheres in aorta tunica adventitia +relationship: RO:0000052 UBERON:0004664 ! inheres in aorta tunica adventitia [Term] id: OBA:0004888 @@ -146260,8 +245614,8 @@ synonym: "morphology of aorta tunica intima" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003619 ! aorta tunica intima -relationship: inheres_in UBERON:0003619 ! aorta tunica intima +intersection_of: RO:0000052 UBERON:0003619 ! inheres in aorta tunica intima +relationship: RO:0000052 UBERON:0003619 ! inheres in aorta tunica intima [Term] id: OBA:0004889 @@ -146271,8 +245625,8 @@ synonym: "morphology of aorta tunica media" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003618 ! aorta tunica media -relationship: inheres_in UBERON:0003618 ! aorta tunica media +intersection_of: RO:0000052 UBERON:0003618 ! inheres in aorta tunica media +relationship: RO:0000052 UBERON:0003618 ! inheres in aorta tunica media [Term] id: OBA:0004890 @@ -146282,8 +245636,8 @@ synonym: "morphology of cervical vertebra 1 arcus anterior" EXACT [AUTO:patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003996 ! cervical vertebra 1 arcus anterior -relationship: inheres_in UBERON:0003996 ! cervical vertebra 1 arcus anterior +intersection_of: RO:0000052 UBERON:0003996 ! inheres in cervical vertebra 1 arcus anterior +relationship: RO:0000052 UBERON:0003996 ! inheres in cervical vertebra 1 arcus anterior [Term] id: OBA:0004891 @@ -146293,8 +245647,8 @@ synonym: "amount of secondary palatal shelf" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005619 ! secondary palatal shelf -relationship: inheres_in UBERON:0005619 ! secondary palatal shelf +intersection_of: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf +relationship: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf [Term] id: OBA:0004892 @@ -146304,7 +245658,7 @@ synonym: "size of secondary palatal shelf" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000431 ! palatine shelf morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005619 ! secondary palatal shelf +intersection_of: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf [Term] id: OBA:0004893 @@ -146314,8 +245668,8 @@ synonym: "elevation of secondary palatal shelf" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001687 ! elevation intersection_of: PATO:0001687 ! elevation -intersection_of: inheres_in UBERON:0005619 ! secondary palatal shelf -relationship: inheres_in UBERON:0005619 ! secondary palatal shelf +intersection_of: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf +relationship: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf [Term] id: OBA:0004894 @@ -146325,7 +245679,7 @@ synonym: "shape of secondary palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0003755 ! palate morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:0004895 @@ -146336,8 +245690,8 @@ is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000138 ! bone element size is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012071 ! palate bone -relationship: inheres_in UBERON:0012071 ! palate bone +intersection_of: RO:0000052 UBERON:0012071 ! inheres in palate bone +relationship: RO:0000052 UBERON:0012071 ! inheres in palate bone [Term] id: OBA:0004896 @@ -146347,7 +245701,7 @@ synonym: "shape of primary palate" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000832 ! primary palate quality is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0005620 ! primary palate +intersection_of: RO:0000052 UBERON:0005620 ! inheres in primary palate [Term] id: OBA:0004897 @@ -146357,7 +245711,7 @@ synonym: "size of palatine bone horizontal plate" EXACT [AUTO:patterns/patterns/ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004004 ! palatine bone horizontal plate morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0018242 ! palatine bone horizontal plate +intersection_of: RO:0000052 UBERON:0018242 ! inheres in palatine bone horizontal plate [Term] id: OBA:0004898 @@ -146367,7 +245721,7 @@ synonym: "size of palatine process of maxilla" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000430 ! palatine process morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005871 ! palatine process of maxilla +intersection_of: RO:0000052 UBERON:0005871 ! inheres in palatine process of maxilla [Term] id: OBA:0004899 @@ -146377,7 +245731,7 @@ synonym: "size of hyoid bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0003056 ! hyoid bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001685 ! hyoid bone +intersection_of: RO:0000052 UBERON:0001685 ! inheres in hyoid bone [Term] id: OBA:0004900 @@ -146387,7 +245741,7 @@ synonym: "size of vomer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004895 ! palate bone size is_a: OBA:VT0000098 ! vomer bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002396 ! vomer +intersection_of: RO:0000052 UBERON:0002396 ! inheres in vomer [Term] id: OBA:0004901 @@ -146397,8 +245751,8 @@ synonym: "morphology of frontonasal prominence" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004066 ! frontonasal prominence -relationship: inheres_in UBERON:0004066 ! frontonasal prominence +intersection_of: RO:0000052 UBERON:0004066 ! inheres in frontonasal prominence +relationship: RO:0000052 UBERON:0004066 ! inheres in frontonasal prominence [Term] id: OBA:0004902 @@ -146408,8 +245762,8 @@ synonym: "morphology of lateral nasal prominence" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004067 ! lateral nasal prominence -relationship: inheres_in UBERON:0004067 ! lateral nasal prominence +intersection_of: RO:0000052 UBERON:0004067 ! inheres in lateral nasal prominence +relationship: RO:0000052 UBERON:0004067 ! inheres in lateral nasal prominence [Term] id: OBA:0004903 @@ -146419,8 +245773,8 @@ synonym: "morphology of medial nasal prominence" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004068 ! medial nasal prominence -relationship: inheres_in UBERON:0004068 ! medial nasal prominence +intersection_of: RO:0000052 UBERON:0004068 ! inheres in medial nasal prominence +relationship: RO:0000052 UBERON:0004068 ! inheres in medial nasal prominence [Term] id: OBA:0004904 @@ -146430,8 +245784,8 @@ synonym: "amount of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001723 ! tongue -relationship: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue +relationship: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0004905 @@ -146441,7 +245795,7 @@ synonym: "branchiness of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000762 ! tongue morphology trait is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:0004906 @@ -146451,8 +245805,8 @@ synonym: "morphology of hyoid bone greater horn" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003997 ! hyoid bone greater horn -relationship: inheres_in UBERON:0003997 ! hyoid bone greater horn +intersection_of: RO:0000052 UBERON:0003997 ! inheres in hyoid bone greater horn +relationship: RO:0000052 UBERON:0003997 ! inheres in hyoid bone greater horn [Term] id: OBA:0004907 @@ -146462,8 +245816,8 @@ synonym: "morphology of hyoid bone lesser horn" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003998 ! hyoid bone lesser horn -relationship: inheres_in UBERON:0003998 ! hyoid bone lesser horn +intersection_of: RO:0000052 UBERON:0003998 ! inheres in hyoid bone lesser horn +relationship: RO:0000052 UBERON:0003998 ! inheres in hyoid bone lesser horn [Term] id: OBA:0004908 @@ -146473,8 +245827,8 @@ synonym: "amount of hyoid bone lesser horn" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003998 ! hyoid bone lesser horn -relationship: inheres_in UBERON:0003998 ! hyoid bone lesser horn +intersection_of: RO:0000052 UBERON:0003998 ! inheres in hyoid bone lesser horn +relationship: RO:0000052 UBERON:0003998 ! inheres in hyoid bone lesser horn [Term] id: OBA:0004909 @@ -146484,8 +245838,8 @@ synonym: "amount of hyoid bone greater horn" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003997 ! hyoid bone greater horn -relationship: inheres_in UBERON:0003997 ! hyoid bone greater horn +intersection_of: RO:0000052 UBERON:0003997 ! inheres in hyoid bone greater horn +relationship: RO:0000052 UBERON:0003997 ! inheres in hyoid bone greater horn [Term] id: OBA:0004910 @@ -146495,8 +245849,8 @@ synonym: "morphology of hyoid bone body" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003999 ! hyoid bone body -relationship: inheres_in UBERON:0003999 ! hyoid bone body +intersection_of: RO:0000052 UBERON:0003999 ! inheres in hyoid bone body +relationship: RO:0000052 UBERON:0003999 ! inheres in hyoid bone body [Term] id: OBA:0004911 @@ -146505,8 +245859,8 @@ def: "The morphology of a stylohyoid ligament." [AUTO:patterns/patterns/entity_a synonym: "morphology of stylohyoid ligament" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004361 ! stylohyoid ligament -relationship: inheres_in UBERON:0004361 ! stylohyoid ligament +intersection_of: RO:0000052 UBERON:0004361 ! inheres in stylohyoid ligament +relationship: RO:0000052 UBERON:0004361 ! inheres in stylohyoid ligament [Term] id: OBA:0004912 @@ -146515,8 +245869,8 @@ def: "The amount of a T1 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of T1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004320 ! transitional stage B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000958 ! T1 B cell -relationship: inheres_in CL:0000958 ! T1 B cell +intersection_of: RO:0000052 CL:0000958 ! inheres in T1 B cell +relationship: RO:0000052 CL:0000958 ! inheres in T1 B cell [Term] id: OBA:0004913 @@ -146525,8 +245879,8 @@ def: "The amount of a T2 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of T2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004320 ! transitional stage B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000959 ! T2 B cell -relationship: inheres_in CL:0000959 ! T2 B cell +intersection_of: RO:0000052 CL:0000959 ! inheres in T2 B cell +relationship: RO:0000052 CL:0000959 ! inheres in T2 B cell [Term] id: OBA:0004914 @@ -146536,8 +245890,8 @@ synonym: "morphology of tarsal gland acinus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004000 ! tarsal gland acinus -relationship: inheres_in UBERON:0004000 ! tarsal gland acinus +intersection_of: RO:0000052 UBERON:0004000 ! inheres in tarsal gland acinus +relationship: RO:0000052 UBERON:0004000 ! inheres in tarsal gland acinus [Term] id: OBA:0004915 @@ -146546,8 +245900,8 @@ def: "The morphology of a dendritic spine." [AUTO:patterns/patterns/entity_attri synonym: "morphology of dendritic spine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015108 ! neurite morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0043197 ! dendritic spine -relationship: inheres_in GO:0043197 ! dendritic spine +intersection_of: RO:0000052 GO:0043197 ! inheres in dendritic spine +relationship: RO:0000052 GO:0043197 ! inheres in dendritic spine [Term] id: OBA:0004916 @@ -146555,10 +245909,10 @@ name: hippocampal granule cell morphology def: "The morphology of a hippocampal granule cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hippocampal granule cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000922 ! granule cell quality -is_a: OBA:VT0002882 ! neuron morphology trait +is_a: OBA:VT0015046 ! hippocampus neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0001033 ! hippocampal granule cell -relationship: inheres_in CL:0001033 ! hippocampal granule cell +intersection_of: RO:0000052 CL:0001033 ! inheres in hippocampal granule cell +relationship: RO:0000052 CL:0001033 ! inheres in hippocampal granule cell [Term] id: OBA:0004917 @@ -146566,10 +245920,10 @@ name: periglomerular cell morphology def: "The morphology of a periglomerular cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of periglomerular cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait -is_a: OBA:VT0006004 ! interneuron morphology trait +is_a: OBA:VT0004101 ! brain interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001435 ! periglomerular cell -relationship: inheres_in CL:1001435 ! periglomerular cell +intersection_of: RO:0000052 CL:1001435 ! inheres in periglomerular cell +relationship: RO:0000052 CL:1001435 ! inheres in periglomerular cell [Term] id: OBA:0004918 @@ -146579,8 +245933,8 @@ synonym: "morphology of accessory olfactory bulb" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004069 ! accessory olfactory bulb -relationship: inheres_in UBERON:0004069 ! accessory olfactory bulb +intersection_of: RO:0000052 UBERON:0004069 ! inheres in accessory olfactory bulb +relationship: RO:0000052 UBERON:0004069 ! inheres in accessory olfactory bulb [Term] id: OBA:0004919 @@ -146590,8 +245944,8 @@ synonym: "morphology of olfactory bulb layer" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004001 ! olfactory bulb layer -relationship: inheres_in UBERON:0004001 ! olfactory bulb layer +intersection_of: RO:0000052 UBERON:0004001 ! inheres in olfactory bulb layer +relationship: RO:0000052 UBERON:0004001 ! inheres in olfactory bulb layer [Term] id: OBA:0004920 @@ -146600,8 +245954,8 @@ def: "The morphology of a olfactory bulb external plexiform layer." [AUTO:patter synonym: "morphology of olfactory bulb external plexiform layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005376 ! olfactory bulb external plexiform layer -relationship: inheres_in UBERON:0005376 ! olfactory bulb external plexiform layer +intersection_of: RO:0000052 UBERON:0005376 ! inheres in olfactory bulb external plexiform layer +relationship: RO:0000052 UBERON:0005376 ! inheres in olfactory bulb external plexiform layer [Term] id: OBA:0004921 @@ -146610,8 +245964,8 @@ def: "The morphology of a olfactory bulb glomerular layer." [AUTO:patterns/patte synonym: "morphology of olfactory bulb glomerular layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005377 ! olfactory bulb glomerular layer -relationship: inheres_in UBERON:0005377 ! olfactory bulb glomerular layer +intersection_of: RO:0000052 UBERON:0005377 ! inheres in olfactory bulb glomerular layer +relationship: RO:0000052 UBERON:0005377 ! inheres in olfactory bulb glomerular layer [Term] id: OBA:0004922 @@ -146620,8 +245974,8 @@ def: "The morphology of a olfactory bulb granule cell layer." [AUTO:patterns/pat synonym: "morphology of olfactory bulb granule cell layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005378 ! olfactory bulb granule cell layer -relationship: inheres_in UBERON:0005378 ! olfactory bulb granule cell layer +intersection_of: RO:0000052 UBERON:0005378 ! inheres in olfactory bulb granule cell layer +relationship: RO:0000052 UBERON:0005378 ! inheres in olfactory bulb granule cell layer [Term] id: OBA:0004923 @@ -146630,8 +245984,8 @@ def: "The morphology of a olfactory bulb internal plexiform layer." [AUTO:patter synonym: "morphology of olfactory bulb internal plexiform layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005379 ! olfactory bulb internal plexiform layer -relationship: inheres_in UBERON:0005379 ! olfactory bulb internal plexiform layer +intersection_of: RO:0000052 UBERON:0005379 ! inheres in olfactory bulb internal plexiform layer +relationship: RO:0000052 UBERON:0005379 ! inheres in olfactory bulb internal plexiform layer [Term] id: OBA:0004924 @@ -146640,8 +245994,8 @@ def: "The morphology of a olfactory bulb mitral cell layer." [AUTO:patterns/patt synonym: "morphology of olfactory bulb mitral cell layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004186 ! olfactory bulb mitral cell layer -relationship: inheres_in UBERON:0004186 ! olfactory bulb mitral cell layer +intersection_of: RO:0000052 UBERON:0004186 ! inheres in olfactory bulb mitral cell layer +relationship: RO:0000052 UBERON:0004186 ! inheres in olfactory bulb mitral cell layer [Term] id: OBA:0004925 @@ -146650,8 +246004,8 @@ def: "The morphology of a olfactory bulb subependymal zone." [AUTO:patterns/patt synonym: "morphology of olfactory bulb subependymal zone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005380 ! olfactory bulb subependymal zone -relationship: inheres_in UBERON:0005380 ! olfactory bulb subependymal zone +intersection_of: RO:0000052 UBERON:0005380 ! inheres in olfactory bulb subependymal zone +relationship: RO:0000052 UBERON:0005380 ! inheres in olfactory bulb subependymal zone [Term] id: OBA:0004926 @@ -146661,8 +246015,8 @@ synonym: "morphology of olfactory tubercle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001883 ! olfactory tubercle -relationship: inheres_in UBERON:0001883 ! olfactory tubercle +intersection_of: RO:0000052 UBERON:0001883 ! inheres in olfactory tubercle +relationship: RO:0000052 UBERON:0001883 ! inheres in olfactory tubercle [Term] id: OBA:0004927 @@ -146670,10 +246024,10 @@ name: mitral cell morphology def: "The morphology of a mitral cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of mitral cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait -is_a: OBA:VT0006004 ! interneuron morphology trait +is_a: OBA:VT0004101 ! brain interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001502 ! mitral cell -relationship: inheres_in CL:1001502 ! mitral cell +intersection_of: RO:0000052 CL:1001502 ! inheres in mitral cell +relationship: RO:0000052 CL:1001502 ! inheres in mitral cell [Term] id: OBA:0004928 @@ -146682,8 +246036,8 @@ def: "The morphology of a olfactory bulb tufted cell." [AUTO:patterns/patterns/e synonym: "morphology of olfactory bulb tufted cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001503 ! olfactory bulb tufted cell -relationship: inheres_in CL:1001503 ! olfactory bulb tufted cell +intersection_of: RO:0000052 CL:1001503 ! inheres in olfactory bulb tufted cell +relationship: RO:0000052 CL:1001503 ! inheres in olfactory bulb tufted cell [Term] id: OBA:0004929 @@ -146693,8 +246047,8 @@ synonym: "morphology of cerebellar layer" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004130 ! cerebellar layer -relationship: inheres_in UBERON:0004130 ! cerebellar layer +intersection_of: RO:0000052 UBERON:0004130 ! inheres in cerebellar layer +relationship: RO:0000052 UBERON:0004130 ! inheres in cerebellar layer [Term] id: OBA:0004930 @@ -146703,8 +246057,8 @@ def: "The amount of a cerebellar granule cell." [AUTO:patterns/patterns/entity_a synonym: "amount of cerebellar granule cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004534 ! granule cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0001031 ! cerebellar granule cell -relationship: inheres_in CL:0001031 ! cerebellar granule cell +intersection_of: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell +relationship: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell [Term] id: OBA:0004931 @@ -146714,8 +246068,8 @@ synonym: "morphology of cerebellar hemisphere" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002245 ! cerebellar hemisphere -relationship: inheres_in UBERON:0002245 ! cerebellar hemisphere +intersection_of: RO:0000052 UBERON:0002245 ! inheres in cerebellar hemisphere +relationship: RO:0000052 UBERON:0002245 ! inheres in cerebellar hemisphere [Term] id: OBA:0004932 @@ -146725,8 +246079,8 @@ synonym: "morphology of anterior lobe of cerebellum" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002131 ! anterior lobe of cerebellum -relationship: inheres_in UBERON:0002131 ! anterior lobe of cerebellum +intersection_of: RO:0000052 UBERON:0002131 ! inheres in anterior lobe of cerebellum +relationship: RO:0000052 UBERON:0002131 ! inheres in anterior lobe of cerebellum [Term] id: OBA:0004933 @@ -146736,8 +246090,8 @@ synonym: "morphology of flocculonodular lobe" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003012 ! flocculonodular lobe -relationship: inheres_in UBERON:0003012 ! flocculonodular lobe +intersection_of: RO:0000052 UBERON:0003012 ! inheres in flocculonodular lobe +relationship: RO:0000052 UBERON:0003012 ! inheres in flocculonodular lobe [Term] id: OBA:0004934 @@ -146747,8 +246101,8 @@ synonym: "morphology of posterior lobe of cerebellum" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004002 ! posterior lobe of cerebellum -relationship: inheres_in UBERON:0004002 ! posterior lobe of cerebellum +intersection_of: RO:0000052 UBERON:0004002 ! inheres in posterior lobe of cerebellum +relationship: RO:0000052 UBERON:0004002 ! inheres in posterior lobe of cerebellum [Term] id: OBA:0004935 @@ -146757,8 +246111,8 @@ def: "The morphology of a cerebellum hemisphere lobule." [AUTO:patterns/patterns synonym: "morphology of cerebellum hemisphere lobule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004936 ! cerebellum lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004003 ! cerebellum hemisphere lobule -relationship: inheres_in UBERON:0004003 ! cerebellum hemisphere lobule +intersection_of: RO:0000052 UBERON:0004003 ! inheres in cerebellum hemisphere lobule +relationship: RO:0000052 UBERON:0004003 ! inheres in cerebellum hemisphere lobule [Term] id: OBA:0004936 @@ -146768,8 +246122,8 @@ synonym: "morphology of cerebellum lobule" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004004 ! cerebellum lobule -relationship: inheres_in UBERON:0004004 ! cerebellum lobule +intersection_of: RO:0000052 UBERON:0004004 ! inheres in cerebellum lobule +relationship: RO:0000052 UBERON:0004004 ! inheres in cerebellum lobule [Term] id: OBA:0004937 @@ -146779,8 +246133,8 @@ synonym: "morphology of cerebrocerebellum" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014644 ! cerebrocerebellum -relationship: inheres_in UBERON:0014644 ! cerebrocerebellum +intersection_of: RO:0000052 UBERON:0014644 ! inheres in cerebrocerebellum +relationship: RO:0000052 UBERON:0014644 ! inheres in cerebrocerebellum [Term] id: OBA:0004938 @@ -146790,8 +246144,8 @@ synonym: "morphology of cerebellum intermediate zone" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004006 ! cerebellum intermediate zone -relationship: inheres_in UBERON:0004006 ! cerebellum intermediate zone +intersection_of: RO:0000052 UBERON:0004006 ! inheres in cerebellum intermediate zone +relationship: RO:0000052 UBERON:0004006 ! inheres in cerebellum intermediate zone [Term] id: OBA:0004939 @@ -146801,7 +246155,7 @@ synonym: "morphology of cerebellar peduncle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0004276 ! brain white matter morphology is_a: OBA:1000442 ! cerebellar peduncle quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007416 ! cerebellar peduncle +intersection_of: RO:0000052 UBERON:0007416 ! inheres in cerebellar peduncle [Term] id: OBA:0004940 @@ -146811,8 +246165,8 @@ synonym: "morphology of white matter of cerebellum" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002317 ! white matter of cerebellum -relationship: inheres_in UBERON:0002317 ! white matter of cerebellum +intersection_of: RO:0000052 UBERON:0002317 ! inheres in white matter of cerebellum +relationship: RO:0000052 UBERON:0002317 ! inheres in white matter of cerebellum [Term] id: OBA:0004941 @@ -146822,8 +246176,8 @@ synonym: "morphology of nucleus of cerebellar nuclear complex" EXACT [AUTO:patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008995 ! nucleus of cerebellar nuclear complex -relationship: inheres_in UBERON:0008995 ! nucleus of cerebellar nuclear complex +intersection_of: RO:0000052 UBERON:0008995 ! inheres in nucleus of cerebellar nuclear complex +relationship: RO:0000052 UBERON:0008995 ! inheres in nucleus of cerebellar nuclear complex [Term] id: OBA:0004942 @@ -146833,7 +246187,7 @@ synonym: "morphology of dentate nucleus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004941 ! nucleus of cerebellar nuclear complex morphology is_a: OBA:1000206 ! dentate nucleus quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002132 ! dentate nucleus +intersection_of: RO:0000052 UBERON:0002132 ! inheres in dentate nucleus [Term] id: OBA:0004943 @@ -146842,8 +246196,8 @@ def: "The morphology of a emboliform nucleus." [AUTO:patterns/patterns/entity_at synonym: "morphology of emboliform nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004946 ! cerebellum interpositus nucleus morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002602 ! emboliform nucleus -relationship: inheres_in UBERON:0002602 ! emboliform nucleus +intersection_of: RO:0000052 UBERON:0002602 ! inheres in emboliform nucleus +relationship: RO:0000052 UBERON:0002602 ! inheres in emboliform nucleus [Term] id: OBA:0004944 @@ -146852,8 +246206,8 @@ def: "The morphology of a cerebellum globose nucleus." [AUTO:patterns/patterns/e synonym: "morphology of cerebellum globose nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004946 ! cerebellum interpositus nucleus morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002613 ! cerebellum globose nucleus -relationship: inheres_in UBERON:0002613 ! cerebellum globose nucleus +intersection_of: RO:0000052 UBERON:0002613 ! inheres in cerebellum globose nucleus +relationship: RO:0000052 UBERON:0002613 ! inheres in cerebellum globose nucleus [Term] id: OBA:0004945 @@ -146862,8 +246216,8 @@ def: "The morphology of a fastigial nucleus." [AUTO:patterns/patterns/entity_att synonym: "morphology of fastigial nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004941 ! nucleus of cerebellar nuclear complex morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002153 ! fastigial nucleus -relationship: inheres_in UBERON:0002153 ! fastigial nucleus +intersection_of: RO:0000052 UBERON:0002153 ! inheres in fastigial nucleus +relationship: RO:0000052 UBERON:0002153 ! inheres in fastigial nucleus [Term] id: OBA:0004946 @@ -146872,8 +246226,8 @@ def: "The morphology of a cerebellum interpositus nucleus." [AUTO:patterns/patte synonym: "morphology of cerebellum interpositus nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004941 ! nucleus of cerebellar nuclear complex morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004073 ! cerebellum interpositus nucleus -relationship: inheres_in UBERON:0004073 ! cerebellum interpositus nucleus +intersection_of: RO:0000052 UBERON:0004073 ! inheres in cerebellum interpositus nucleus +relationship: RO:0000052 UBERON:0004073 ! inheres in cerebellum interpositus nucleus [Term] id: OBA:0004947 @@ -146882,8 +246236,8 @@ def: "The morphology of a inferior cerebellar peduncle." [AUTO:patterns/patterns synonym: "morphology of inferior cerebellar peduncle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004939 ! cerebellar peduncle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002163 ! inferior cerebellar peduncle -relationship: inheres_in UBERON:0002163 ! inferior cerebellar peduncle +intersection_of: RO:0000052 UBERON:0002163 ! inheres in inferior cerebellar peduncle +relationship: RO:0000052 UBERON:0002163 ! inheres in inferior cerebellar peduncle [Term] id: OBA:0004948 @@ -146892,8 +246246,8 @@ def: "The morphology of a middle cerebellar peduncle." [AUTO:patterns/patterns/e synonym: "morphology of middle cerebellar peduncle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004939 ! cerebellar peduncle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002152 ! middle cerebellar peduncle -relationship: inheres_in UBERON:0002152 ! middle cerebellar peduncle +intersection_of: RO:0000052 UBERON:0002152 ! inheres in middle cerebellar peduncle +relationship: RO:0000052 UBERON:0002152 ! inheres in middle cerebellar peduncle [Term] id: OBA:0004949 @@ -146902,8 +246256,8 @@ def: "The morphology of a superior cerebellar peduncle." [AUTO:patterns/patterns synonym: "morphology of superior cerebellar peduncle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004939 ! cerebellar peduncle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002150 ! superior cerebellar peduncle -relationship: inheres_in UBERON:0002150 ! superior cerebellar peduncle +intersection_of: RO:0000052 UBERON:0002150 ! inheres in superior cerebellar peduncle +relationship: RO:0000052 UBERON:0002150 ! inheres in superior cerebellar peduncle [Term] id: OBA:0004950 @@ -146912,8 +246266,8 @@ def: "The morphology of a cerebellum vermis lobule I." [AUTO:patterns/patterns/e synonym: "morphology of cerebellum vermis lobule I" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004074 ! cerebellum vermis lobule I -relationship: inheres_in UBERON:0004074 ! cerebellum vermis lobule I +intersection_of: RO:0000052 UBERON:0004074 ! inheres in cerebellum vermis lobule I +relationship: RO:0000052 UBERON:0004074 ! inheres in cerebellum vermis lobule I [Term] id: OBA:0004951 @@ -146922,8 +246276,8 @@ def: "The morphology of a cerebellum vermis lobule II." [AUTO:patterns/patterns/ synonym: "morphology of cerebellum vermis lobule II" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004075 ! cerebellum vermis lobule II -relationship: inheres_in UBERON:0004075 ! cerebellum vermis lobule II +intersection_of: RO:0000052 UBERON:0004075 ! inheres in cerebellum vermis lobule II +relationship: RO:0000052 UBERON:0004075 ! inheres in cerebellum vermis lobule II [Term] id: OBA:0004952 @@ -146932,8 +246286,8 @@ def: "The morphology of a cerebellum vermis lobule III." [AUTO:patterns/patterns synonym: "morphology of cerebellum vermis lobule III" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004076 ! cerebellum vermis lobule III -relationship: inheres_in UBERON:0004076 ! cerebellum vermis lobule III +intersection_of: RO:0000052 UBERON:0004076 ! inheres in cerebellum vermis lobule III +relationship: RO:0000052 UBERON:0004076 ! inheres in cerebellum vermis lobule III [Term] id: OBA:0004953 @@ -146942,8 +246296,8 @@ def: "The morphology of a cerebellum vermis lobule IV." [AUTO:patterns/patterns/ synonym: "morphology of cerebellum vermis lobule IV" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004077 ! cerebellum vermis lobule IV -relationship: inheres_in UBERON:0004077 ! cerebellum vermis lobule IV +intersection_of: RO:0000052 UBERON:0004077 ! inheres in cerebellum vermis lobule IV +relationship: RO:0000052 UBERON:0004077 ! inheres in cerebellum vermis lobule IV [Term] id: OBA:0004954 @@ -146952,8 +246306,8 @@ def: "The morphology of a cerebellum vermis lobule V." [AUTO:patterns/patterns/e synonym: "morphology of cerebellum vermis lobule V" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004079 ! cerebellum vermis lobule V -relationship: inheres_in UBERON:0004079 ! cerebellum vermis lobule V +intersection_of: RO:0000052 UBERON:0004079 ! inheres in cerebellum vermis lobule V +relationship: RO:0000052 UBERON:0004079 ! inheres in cerebellum vermis lobule V [Term] id: OBA:0004955 @@ -146962,8 +246316,8 @@ def: "The morphology of a cerebellum vermis lobule VI." [AUTO:patterns/patterns/ synonym: "morphology of cerebellum vermis lobule VI" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004080 ! cerebellum vermis lobule VI -relationship: inheres_in UBERON:0004080 ! cerebellum vermis lobule VI +intersection_of: RO:0000052 UBERON:0004080 ! inheres in cerebellum vermis lobule VI +relationship: RO:0000052 UBERON:0004080 ! inheres in cerebellum vermis lobule VI [Term] id: OBA:0004956 @@ -146972,8 +246326,8 @@ def: "The morphology of a cerebellum vermis lobule VII." [AUTO:patterns/patterns synonym: "morphology of cerebellum vermis lobule VII" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004081 ! cerebellum vermis lobule VII -relationship: inheres_in UBERON:0004081 ! cerebellum vermis lobule VII +intersection_of: RO:0000052 UBERON:0004081 ! inheres in cerebellum vermis lobule VII +relationship: RO:0000052 UBERON:0004081 ! inheres in cerebellum vermis lobule VII [Term] id: OBA:0004957 @@ -146982,8 +246336,8 @@ def: "The morphology of a cerebellum vermis lobule X." [AUTO:patterns/patterns/e synonym: "morphology of cerebellum vermis lobule X" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004083 ! cerebellum vermis lobule X -relationship: inheres_in UBERON:0004083 ! cerebellum vermis lobule X +intersection_of: RO:0000052 UBERON:0004083 ! inheres in cerebellum vermis lobule X +relationship: RO:0000052 UBERON:0004083 ! inheres in cerebellum vermis lobule X [Term] id: OBA:0004958 @@ -146992,8 +246346,8 @@ def: "The morphology of a cerebellum vermis lobule VIIA." [AUTO:patterns/pattern synonym: "morphology of cerebellum vermis lobule VIIA" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004956 ! cerebellum vermis lobule VII morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005345 ! cerebellum vermis lobule VIIA -relationship: inheres_in UBERON:0005345 ! cerebellum vermis lobule VIIA +intersection_of: RO:0000052 UBERON:0005345 ! inheres in cerebellum vermis lobule VIIA +relationship: RO:0000052 UBERON:0005345 ! inheres in cerebellum vermis lobule VIIA [Term] id: OBA:0004959 @@ -147002,8 +246356,8 @@ def: "The morphology of a cerebellum vermis lobule VIIB." [AUTO:patterns/pattern synonym: "morphology of cerebellum vermis lobule VIIB" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004956 ! cerebellum vermis lobule VII morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005346 ! cerebellum vermis lobule VIIB -relationship: inheres_in UBERON:0005346 ! cerebellum vermis lobule VIIB +intersection_of: RO:0000052 UBERON:0005346 ! inheres in cerebellum vermis lobule VIIB +relationship: RO:0000052 UBERON:0005346 ! inheres in cerebellum vermis lobule VIIB [Term] id: OBA:0004960 @@ -147012,8 +246366,8 @@ def: "The morphology of a copula pyramidis." [AUTO:patterns/patterns/entity_attr synonym: "morphology of copula pyramidis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004935 ! cerebellum hemisphere lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005347 ! copula pyramidis -relationship: inheres_in UBERON:0005347 ! copula pyramidis +intersection_of: RO:0000052 UBERON:0005347 ! inheres in copula pyramidis +relationship: RO:0000052 UBERON:0005347 ! inheres in copula pyramidis [Term] id: OBA:0004961 @@ -147022,8 +246376,8 @@ def: "The morphology of a ansiform lobule." [AUTO:patterns/patterns/entity_attri synonym: "morphology of ansiform lobule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004935 ! cerebellum hemisphere lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005348 ! ansiform lobule -relationship: inheres_in UBERON:0005348 ! ansiform lobule +intersection_of: RO:0000052 UBERON:0005348 ! inheres in ansiform lobule +relationship: RO:0000052 UBERON:0005348 ! inheres in ansiform lobule [Term] id: OBA:0004962 @@ -147032,8 +246386,8 @@ def: "The morphology of a ansiform lobule crus I." [AUTO:patterns/patterns/entit synonym: "morphology of ansiform lobule crus I" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004961 ! ansiform lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005976 ! ansiform lobule crus I -relationship: inheres_in UBERON:0005976 ! ansiform lobule crus I +intersection_of: RO:0000052 UBERON:0005976 ! inheres in ansiform lobule crus I +relationship: RO:0000052 UBERON:0005976 ! inheres in ansiform lobule crus I [Term] id: OBA:0004963 @@ -147042,8 +246396,8 @@ def: "The morphology of a ansiform lobule crus II." [AUTO:patterns/patterns/enti synonym: "morphology of ansiform lobule crus II" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004961 ! ansiform lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005977 ! ansiform lobule crus II -relationship: inheres_in UBERON:0005977 ! ansiform lobule crus II +intersection_of: RO:0000052 UBERON:0005977 ! inheres in ansiform lobule crus II +relationship: RO:0000052 UBERON:0005977 ! inheres in ansiform lobule crus II [Term] id: OBA:0004964 @@ -147052,8 +246406,8 @@ def: "The morphology of a paramedian lobule." [AUTO:patterns/patterns/entity_att synonym: "morphology of paramedian lobule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005349 ! paramedian lobule -relationship: inheres_in UBERON:0005349 ! paramedian lobule +intersection_of: RO:0000052 UBERON:0005349 ! inheres in paramedian lobule +relationship: RO:0000052 UBERON:0005349 ! inheres in paramedian lobule [Term] id: OBA:0004965 @@ -147062,8 +246416,8 @@ def: "The morphology of a lobule simplex." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of lobule simplex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004935 ! cerebellum hemisphere lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005350 ! lobule simplex -relationship: inheres_in UBERON:0005350 ! lobule simplex +intersection_of: RO:0000052 UBERON:0005350 ! inheres in lobule simplex +relationship: RO:0000052 UBERON:0005350 ! inheres in lobule simplex [Term] id: OBA:0004966 @@ -147073,8 +246427,8 @@ synonym: "morphology of flocculus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001063 ! flocculus -relationship: inheres_in UBERON:0001063 ! flocculus +intersection_of: RO:0000052 UBERON:0001063 ! inheres in flocculus +relationship: RO:0000052 UBERON:0001063 ! inheres in flocculus [Term] id: OBA:0004967 @@ -147083,8 +246437,8 @@ def: "The morphology of a paraflocculus." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of paraflocculus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004935 ! cerebellum hemisphere lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005351 ! paraflocculus -relationship: inheres_in UBERON:0005351 ! paraflocculus +intersection_of: RO:0000052 UBERON:0005351 ! inheres in paraflocculus +relationship: RO:0000052 UBERON:0005351 ! inheres in paraflocculus [Term] id: OBA:0004968 @@ -147094,8 +246448,8 @@ synonym: "morphology of piriform cortex" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004725 ! piriform cortex -relationship: inheres_in UBERON:0004725 ! piriform cortex +intersection_of: RO:0000052 UBERON:0004725 ! inheres in piriform cortex +relationship: RO:0000052 UBERON:0004725 ! inheres in piriform cortex [Term] id: OBA:0004969 @@ -147105,18 +246459,18 @@ synonym: "morphology of island of Calleja" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001881 ! island of Calleja -relationship: inheres_in UBERON:0001881 ! island of Calleja +intersection_of: RO:0000052 UBERON:0001881 ! inheres in island of Calleja +relationship: RO:0000052 UBERON:0001881 ! inheres in island of Calleja [Term] id: OBA:0004970 name: hippocampal pyramidal neuron displaced def: "The displaced of a hippocampal pyramidal neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "displaced of hippocampal pyramidal neuron" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0005527 ! neuron displaced +is_a: OBA:0005528 ! cerebral cortex neuron displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:1001571 ! hippocampal pyramidal neuron -relationship: inheres_in CL:1001571 ! hippocampal pyramidal neuron +intersection_of: RO:0000052 CL:1001571 ! inheres in hippocampal pyramidal neuron +relationship: RO:0000052 CL:1001571 ! inheres in hippocampal pyramidal neuron [Term] id: OBA:0004971 @@ -147126,8 +246480,8 @@ synonym: "morphology of cuticular plate" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0032437 ! cuticular plate -relationship: inheres_in GO:0032437 ! cuticular plate +intersection_of: RO:0000052 GO:0032437 ! inheres in cuticular plate +relationship: RO:0000052 GO:0032437 ! inheres in cuticular plate [Term] id: OBA:0004972 @@ -147137,7 +246491,7 @@ synonym: "structure of lung blood vessel" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003463 ! blood vessel structure is_a: OBA:VT0004007 ! lung blood vessel morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003512 ! lung blood vessel +intersection_of: RO:0000052 UBERON:0003512 ! inheres in lung blood vessel [Term] id: OBA:0004973 @@ -147147,8 +246501,8 @@ synonym: "structure of heart blood vessel" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003463 ! blood vessel structure is_a: OBA:0005089 ! coronary vessel morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003498 ! heart blood vessel -relationship: inheres_in UBERON:0003498 ! heart blood vessel +intersection_of: RO:0000052 UBERON:0003498 ! inheres in heart blood vessel +relationship: RO:0000052 UBERON:0003498 ! inheres in heart blood vessel [Term] id: OBA:0004974 @@ -147157,8 +246511,8 @@ def: "The structure of a brain blood vessel." [AUTO:patterns/patterns/entity_att synonym: "structure of brain blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003463 ! blood vessel structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0003499 ! brain blood vessel -relationship: inheres_in UBERON:0003499 ! brain blood vessel +intersection_of: RO:0000052 UBERON:0003499 ! inheres in brain blood vessel +relationship: RO:0000052 UBERON:0003499 ! inheres in brain blood vessel [Term] id: OBA:0004975 @@ -147168,18 +246522,18 @@ synonym: "displaced of melanocyte" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000076 ! attribute of cell is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000148 ! melanocyte -relationship: inheres_in CL:0000148 ! melanocyte +intersection_of: RO:0000052 CL:0000148 ! inheres in melanocyte +relationship: RO:0000052 CL:0000148 ! inheres in melanocyte [Term] id: OBA:0004976 name: hepatic oval stem cell morphology def: "The morphology of a hepatic oval stem cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hepatic oval stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:VT0002400 ! multipotent stem cell morphology trait +is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002196 ! hepatic oval stem cell -relationship: inheres_in CL:0002196 ! hepatic oval stem cell +intersection_of: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell +relationship: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell [Term] id: OBA:0004977 @@ -147189,8 +246543,8 @@ synonym: "amount of hepatic oval stem cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002196 ! hepatic oval stem cell -relationship: inheres_in CL:0002196 ! hepatic oval stem cell +intersection_of: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell +relationship: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell [Term] id: OBA:0004978 @@ -147199,8 +246553,8 @@ def: "The functionality of a hepatic oval stem cell." [AUTO:patterns/patterns/en synonym: "functionality of hepatic oval stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002196 ! hepatic oval stem cell -relationship: inheres_in CL:0002196 ! hepatic oval stem cell +intersection_of: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell +relationship: RO:0000052 CL:0002196 ! inheres in hepatic oval stem cell [Term] id: OBA:0004979 @@ -147209,8 +246563,8 @@ def: "The morphology of a frontonasal suture." [AUTO:patterns/patterns/entity_at synonym: "morphology of frontonasal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003754 ! skeletal joint morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005404 ! frontonasal suture -relationship: inheres_in UBERON:0005404 ! frontonasal suture +intersection_of: RO:0000052 UBERON:0005404 ! inheres in frontonasal suture +relationship: RO:0000052 UBERON:0005404 ! inheres in frontonasal suture [Term] id: OBA:0004980 @@ -147219,8 +246573,8 @@ def: "The morphology of a omental fat pad." [AUTO:patterns/patterns/entity_attri synonym: "morphology of omental fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005337 ! retroperitoneal fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010414 ! omental fat pad -relationship: inheres_in UBERON:0010414 ! omental fat pad +intersection_of: RO:0000052 UBERON:0010414 ! inheres in omental fat pad +relationship: RO:0000052 UBERON:0010414 ! inheres in omental fat pad [Term] id: OBA:0004981 @@ -147229,8 +246583,8 @@ def: "The mass of a omental fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of omental fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010430 ! retroperitoneal fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0010414 ! omental fat pad -relationship: inheres_in UBERON:0010414 ! omental fat pad +intersection_of: RO:0000052 UBERON:0010414 ! inheres in omental fat pad +relationship: RO:0000052 UBERON:0010414 ! inheres in omental fat pad [Term] id: OBA:0004982 @@ -147240,7 +246594,7 @@ synonym: "convex 3-D shape of axon" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000117 ! axon shape is_a: PATO:0002007 ! convex 3-D shape intersection_of: PATO:0002007 ! convex 3-D shape -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon [Term] id: OBA:0004983 @@ -147249,8 +246603,8 @@ def: "The functionality of a sensory neuron." [AUTO:patterns/patterns/entity_att synonym: "functionality of sensory neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004072 ! neuron functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000101 ! sensory neuron -relationship: inheres_in CL:0000101 ! sensory neuron +intersection_of: RO:0000052 CL:0000101 ! inheres in sensory neuron +relationship: RO:0000052 CL:0000101 ! inheres in sensory neuron [Term] id: OBA:0004984 @@ -147260,8 +246614,8 @@ synonym: "displaced of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue -relationship: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue +relationship: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:0004985 @@ -147270,8 +246624,8 @@ def: "The morphology of a olfactory bulb outer nerve layer." [AUTO:patterns/patt synonym: "morphology of olfactory bulb outer nerve layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004919 ! olfactory bulb layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005978 ! olfactory bulb outer nerve layer -relationship: inheres_in UBERON:0005978 ! olfactory bulb outer nerve layer +intersection_of: RO:0000052 UBERON:0005978 ! inheres in olfactory bulb outer nerve layer +relationship: RO:0000052 UBERON:0005978 ! inheres in olfactory bulb outer nerve layer [Term] id: OBA:0004986 @@ -147280,8 +246634,8 @@ def: "The functionality of a hepatocyte." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of hepatocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000182 ! hepatocyte -relationship: inheres_in CL:0000182 ! hepatocyte +intersection_of: RO:0000052 CL:0000182 ! inheres in hepatocyte +relationship: RO:0000052 CL:0000182 ! inheres in hepatocyte [Term] id: OBA:0004987 @@ -147291,7 +246645,7 @@ synonym: "color of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003214 ! calcareous tooth color is_a: OBA:VT0005358 ! incisor morphology trait intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:0004988 @@ -147301,7 +246655,7 @@ synonym: "spatial pattern of retina blood vessel" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0002792 ! retina blood vessel morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0003501 ! retina blood vessel +intersection_of: RO:0000052 UBERON:0003501 ! inheres in retina blood vessel [Term] id: OBA:0004989 @@ -147312,7 +246666,7 @@ is_a: OBA:0003760 ! cervical vertebra morphology is_a: OBA:VT0000461 ! presacral vertebra quantity is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0002413 ! cervical vertebra +intersection_of: RO:0000052 UBERON:0002413 ! inheres in cervical vertebra [Term] id: OBA:0004990 @@ -147323,7 +246677,7 @@ is_a: OBA:VT0001539 ! caudal vertebra quantity is_a: OBA:VT0002759 ! caudal vertebra morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0001095 ! caudal vertebra +intersection_of: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra [Term] id: OBA:0004991 @@ -147333,7 +246687,7 @@ synonym: "size of thoracic rib cage" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010092 ! thoracic cage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003252 ! thoracic rib cage +intersection_of: RO:0000052 UBERON:0003252 ! inheres in thoracic rib cage [Term] id: OBA:0004992 @@ -147342,8 +246696,8 @@ def: "The morphology of a sublingual ganglion." [AUTO:patterns/patterns/entity_a synonym: "morphology of sublingual ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005407 ! sublingual ganglion -relationship: inheres_in UBERON:0005407 ! sublingual ganglion +intersection_of: RO:0000052 UBERON:0005407 ! inheres in sublingual ganglion +relationship: RO:0000052 UBERON:0005407 ! inheres in sublingual ganglion [Term] id: OBA:0004993 @@ -147352,8 +246706,8 @@ def: "The morphology of a fused sacrum." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of fused sacrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003690 ! fused sacrum -relationship: inheres_in UBERON:0003690 ! fused sacrum +intersection_of: RO:0000052 UBERON:0003690 ! inheres in fused sacrum +relationship: RO:0000052 UBERON:0003690 ! inheres in fused sacrum [Term] id: OBA:0004994 @@ -147362,8 +246716,8 @@ def: "The morphology of a bone of tail." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of bone of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006068 ! bone of tail -relationship: inheres_in UBERON:0006068 ! bone of tail +intersection_of: RO:0000052 UBERON:0006068 ! inheres in bone of tail +relationship: RO:0000052 UBERON:0006068 ! inheres in bone of tail [Term] id: OBA:0004995 @@ -147372,8 +246726,8 @@ def: "The morphology of a embryonic cloaca." [AUTO:patterns/patterns/entity_attr synonym: "morphology of embryonic cloaca" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015055 ! cloaca morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000163 ! embryonic cloaca -relationship: inheres_in UBERON:0000163 ! embryonic cloaca +intersection_of: RO:0000052 UBERON:0000163 ! inheres in embryonic cloaca +relationship: RO:0000052 UBERON:0000163 ! inheres in embryonic cloaca [Term] id: OBA:0004996 @@ -147383,18 +246737,19 @@ synonym: "morphology of primitive urogenital sinus" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000164 ! primitive urogenital sinus -relationship: inheres_in UBERON:0000164 ! primitive urogenital sinus +intersection_of: RO:0000052 UBERON:0000164 ! inheres in primitive urogenital sinus +relationship: RO:0000052 UBERON:0000164 ! inheres in primitive urogenital sinus [Term] id: OBA:0004997 name: parvocellular neurosecretory cell morphology def: "The morphology of a parvocellular neurosecretory cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of parvocellular neurosecretory cell" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:VT0002181 ! brain cell morphology trait is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001505 ! parvocellular neurosecretory cell -relationship: inheres_in CL:1001505 ! parvocellular neurosecretory cell +intersection_of: RO:0000052 CL:1001505 ! inheres in parvocellular neurosecretory cell +relationship: RO:0000052 CL:1001505 ! inheres in parvocellular neurosecretory cell [Term] id: OBA:0004998 @@ -147403,8 +246758,8 @@ def: "The morphology of a distal visceral endoderm." [AUTO:patterns/patterns/ent synonym: "morphology of distal visceral endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001724 ! extraembryonic endoderm morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004878 ! distal visceral endoderm -relationship: inheres_in UBERON:0004878 ! distal visceral endoderm +intersection_of: RO:0000052 UBERON:0004878 ! inheres in distal visceral endoderm +relationship: RO:0000052 UBERON:0004878 ! inheres in distal visceral endoderm [Term] id: OBA:0004999 @@ -147414,7 +246769,7 @@ synonym: "size of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000067 ! blood morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:0005000 @@ -147424,7 +246779,7 @@ synonym: "organization quality of hair shaft" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0003809 ! hair shaft morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0002074 ! hair shaft +intersection_of: RO:0000052 UBERON:0002074 ! inheres in hair shaft [Term] id: OBA:0005001 @@ -147434,8 +246789,8 @@ synonym: "morphology of spermatic cord" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005352 ! spermatic cord -relationship: inheres_in UBERON:0005352 ! spermatic cord +intersection_of: RO:0000052 UBERON:0005352 ! inheres in spermatic cord +relationship: RO:0000052 UBERON:0005352 ! inheres in spermatic cord [Term] id: OBA:0005002 @@ -147445,7 +246800,7 @@ synonym: "morphology of mandibular ramus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000293 ! mandibular ramus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000401 ! mandibular ramus +intersection_of: RO:0000052 UBERON:0000401 ! inheres in mandibular ramus [Term] id: OBA:0005003 @@ -147454,8 +246809,8 @@ def: "The morphology of a spinal cord ependyma." [AUTO:patterns/patterns/entity_ synonym: "morphology of spinal cord ependyma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002653 ! ependyma morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005359 ! spinal cord ependyma -relationship: inheres_in UBERON:0005359 ! spinal cord ependyma +intersection_of: RO:0000052 UBERON:0005359 ! inheres in spinal cord ependyma +relationship: RO:0000052 UBERON:0005359 ! inheres in spinal cord ependyma [Term] id: OBA:0005004 @@ -147464,8 +246819,8 @@ def: "The morphology of a brain ependyma." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of brain ependyma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002653 ! ependyma morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005357 ! brain ependyma -relationship: inheres_in UBERON:0005357 ! brain ependyma +intersection_of: RO:0000052 UBERON:0005357 ! inheres in brain ependyma +relationship: RO:0000052 UBERON:0005357 ! inheres in brain ependyma [Term] id: OBA:0005005 @@ -147474,8 +246829,8 @@ def: "The morphology of a gastroesophageal sphincter." [AUTO:patterns/patterns/e synonym: "morphology of gastroesophageal sphincter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004550 ! gastroesophageal sphincter -relationship: inheres_in UBERON:0004550 ! gastroesophageal sphincter +intersection_of: RO:0000052 UBERON:0004550 ! inheres in gastroesophageal sphincter +relationship: RO:0000052 UBERON:0004550 ! inheres in gastroesophageal sphincter [Term] id: OBA:0005006 @@ -147484,8 +246839,8 @@ def: "The functionality of a gastroesophageal sphincter." [AUTO:patterns/pattern synonym: "functionality of gastroesophageal sphincter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003691 ! muscle organ functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004550 ! gastroesophageal sphincter -relationship: inheres_in UBERON:0004550 ! gastroesophageal sphincter +intersection_of: RO:0000052 UBERON:0004550 ! inheres in gastroesophageal sphincter +relationship: RO:0000052 UBERON:0004550 ! inheres in gastroesophageal sphincter [Term] id: OBA:0005007 @@ -147495,8 +246850,8 @@ synonym: "functionality of intestine" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000160 ! intestine -relationship: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine +relationship: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0005008 @@ -147505,8 +246860,8 @@ def: "The functionality of a crypt of Lieberkuhn of small intestine." [AUTO:patt synonym: "functionality of crypt of Lieberkuhn of small intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002164 ! gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001241 ! crypt of Lieberkuhn of small intestine -relationship: inheres_in UBERON:0001241 ! crypt of Lieberkuhn of small intestine +intersection_of: RO:0000052 UBERON:0001241 ! inheres in crypt of Lieberkuhn of small intestine +relationship: RO:0000052 UBERON:0001241 ! inheres in crypt of Lieberkuhn of small intestine [Term] id: OBA:0005009 @@ -147516,8 +246871,8 @@ synonym: "amount of CD4-positive, CD25-positive, alpha-beta regulatory T cell" E is_a: OBA:0004108 ! regulatory T cell amount is_a: OBA:0004294 ! CD4-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell -relationship: inheres_in CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell +intersection_of: RO:0000052 CL:0000792 ! inheres in CD4-positive, CD25-positive, alpha-beta regulatory T cell +relationship: RO:0000052 CL:0000792 ! inheres in CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: OBA:0005010 @@ -147526,8 +246881,8 @@ def: "The morphology of a pancreatic centro-acinar cell." [AUTO:patterns/pattern synonym: "morphology of pancreatic centro-acinar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002080 ! pancreatic centro-acinar cell -relationship: inheres_in CL:0002080 ! pancreatic centro-acinar cell +intersection_of: RO:0000052 CL:0002080 ! inheres in pancreatic centro-acinar cell +relationship: RO:0000052 CL:0002080 ! inheres in pancreatic centro-acinar cell [Term] id: OBA:0005011 @@ -147537,8 +246892,8 @@ synonym: "functionality of epithelium of mammary gland" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0003244 ! epithelium of mammary gland -relationship: inheres_in UBERON:0003244 ! epithelium of mammary gland +intersection_of: RO:0000052 UBERON:0003244 ! inheres in epithelium of mammary gland +relationship: RO:0000052 UBERON:0003244 ! inheres in epithelium of mammary gland [Term] id: OBA:0005012 @@ -147547,8 +246902,8 @@ def: "The rate of a mammary gland epithelial cell proliferation." [AUTO:patterns synonym: "rate of mammary gland epithelial cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0033598 ! mammary gland epithelial cell proliferation -relationship: inheres_in GO:0033598 ! mammary gland epithelial cell proliferation +intersection_of: RO:0000052 GO:0033598 ! inheres in mammary gland epithelial cell proliferation +relationship: RO:0000052 GO:0033598 ! inheres in mammary gland epithelial cell proliferation [Term] id: OBA:0005013 @@ -147558,7 +246913,7 @@ synonym: "texture of coat of hair" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003645 ! coat of hair morphology is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair [Term] id: OBA:0005014 @@ -147567,8 +246922,8 @@ def: "The morphology of a CD4-positive helper T cell." [AUTO:patterns/patterns/e synonym: "morphology of CD4-positive helper T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003713 ! CD4-positive, alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000492 ! CD4-positive helper T cell -relationship: inheres_in CL:0000492 ! CD4-positive helper T cell +intersection_of: RO:0000052 CL:0000492 ! inheres in CD4-positive helper T cell +relationship: RO:0000052 CL:0000492 ! inheres in CD4-positive helper T cell [Term] id: OBA:0005015 @@ -147577,8 +246932,8 @@ def: "The morphology of a T follicular helper cell." [AUTO:patterns/patterns/ent synonym: "morphology of T follicular helper cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005014 ! CD4-positive helper T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002038 ! T follicular helper cell -relationship: inheres_in CL:0002038 ! T follicular helper cell +intersection_of: RO:0000052 CL:0002038 ! inheres in T follicular helper cell +relationship: RO:0000052 CL:0002038 ! inheres in T follicular helper cell [Term] id: OBA:0005016 @@ -147587,8 +246942,8 @@ def: "The amount of a T follicular helper cell." [AUTO:patterns/patterns/entity_ synonym: "amount of T follicular helper cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002637 ! CD4-positive helper T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002038 ! T follicular helper cell -relationship: inheres_in CL:0002038 ! T follicular helper cell +intersection_of: RO:0000052 CL:0002038 ! inheres in T follicular helper cell +relationship: RO:0000052 CL:0002038 ! inheres in T follicular helper cell [Term] id: OBA:0005017 @@ -147597,8 +246952,8 @@ def: "The functionality of a T follicular helper cell." [AUTO:patterns/patterns/ synonym: "functionality of T follicular helper cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004148 ! CD4-positive, alpha-beta T cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002038 ! T follicular helper cell -relationship: inheres_in CL:0002038 ! T follicular helper cell +intersection_of: RO:0000052 CL:0002038 ! inheres in T follicular helper cell +relationship: RO:0000052 CL:0002038 ! inheres in T follicular helper cell [Term] id: OBA:0005018 @@ -147607,8 +246962,8 @@ def: "The morphology of a retinal melanocyte." [AUTO:patterns/patterns/entity_at synonym: "morphology of retinal melanocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003749 ! melanocyte morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002485 ! retinal melanocyte -relationship: inheres_in CL:0002485 ! retinal melanocyte +intersection_of: RO:0000052 CL:0002485 ! inheres in retinal melanocyte +relationship: RO:0000052 CL:0002485 ! inheres in retinal melanocyte [Term] id: OBA:0005019 @@ -147618,7 +246973,7 @@ synonym: "amount of lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000145 ! lymphatic vessel quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel [Term] id: OBA:0005020 @@ -147628,8 +246983,8 @@ synonym: "morphology of lymphatic vessel endothelium" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002042 ! lymphatic vessel endothelium -relationship: inheres_in UBERON:0002042 ! lymphatic vessel endothelium +intersection_of: RO:0000052 UBERON:0002042 ! inheres in lymphatic vessel endothelium +relationship: RO:0000052 UBERON:0002042 ! inheres in lymphatic vessel endothelium [Term] id: OBA:0005021 @@ -147638,8 +246993,8 @@ def: "The morphology of a lymphatic vessel smooth muscle." [AUTO:patterns/patter synonym: "morphology of lymphatic vessel smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004232 ! lymphatic vessel smooth muscle -relationship: inheres_in UBERON:0004232 ! lymphatic vessel smooth muscle +intersection_of: RO:0000052 UBERON:0004232 ! inheres in lymphatic vessel smooth muscle +relationship: RO:0000052 UBERON:0004232 ! inheres in lymphatic vessel smooth muscle [Term] id: OBA:0005022 @@ -147649,8 +247004,8 @@ synonym: "morphology of chromosome, telomeric region" EXACT [AUTO:patterns/patte is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region -relationship: inheres_in GO:0000781 ! chromosome, telomeric region +intersection_of: RO:0000052 GO:0000781 ! inheres in chromosome, telomeric region +relationship: RO:0000052 GO:0000781 ! inheres in chromosome, telomeric region [Term] id: OBA:0005023 @@ -147660,7 +247015,7 @@ synonym: "prominence of mandible" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002063 ! mandible position is_a: PATO:0015007 ! prominence intersection_of: PATO:0015007 ! prominence -intersection_of: inheres_in UBERON:0001684 ! mandible +intersection_of: RO:0000052 UBERON:0001684 ! inheres in mandible [Term] id: OBA:0005024 @@ -147669,8 +247024,8 @@ def: "The morphology of a T-helper 17 cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of T-helper 17 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005014 ! CD4-positive helper T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000899 ! T-helper 17 cell -relationship: inheres_in CL:0000899 ! T-helper 17 cell +intersection_of: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell +relationship: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell [Term] id: OBA:0005025 @@ -147679,8 +247034,8 @@ def: "The amount of a T-helper 17 cell." [AUTO:patterns/patterns/entity_attribut synonym: "amount of T-helper 17 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002637 ! CD4-positive helper T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000899 ! T-helper 17 cell -relationship: inheres_in CL:0000899 ! T-helper 17 cell +intersection_of: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell +relationship: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell [Term] id: OBA:0005026 @@ -147689,8 +247044,8 @@ def: "The functionality of a T-helper 17 cell." [AUTO:patterns/patterns/entity_a synonym: "functionality of T-helper 17 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004148 ! CD4-positive, alpha-beta T cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000899 ! T-helper 17 cell -relationship: inheres_in CL:0000899 ! T-helper 17 cell +intersection_of: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell +relationship: RO:0000052 CL:0000899 ! inheres in T-helper 17 cell [Term] id: OBA:0005027 @@ -147699,8 +247054,8 @@ def: "The mass of a quadriceps femoris." [AUTO:patterns/patterns/entity_attribut synonym: "mass of quadriceps femoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001377 ! quadriceps femoris -relationship: inheres_in UBERON:0001377 ! quadriceps femoris +intersection_of: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris +relationship: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris [Term] id: OBA:0005028 @@ -147709,8 +247064,8 @@ def: "The amount of a T3 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of T3 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004320 ! transitional stage B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000960 ! T3 B cell -relationship: inheres_in CL:0000960 ! T3 B cell +intersection_of: RO:0000052 CL:0000960 ! inheres in T3 B cell +relationship: RO:0000052 CL:0000960 ! inheres in T3 B cell [Term] id: OBA:0005029 @@ -147720,7 +247075,7 @@ synonym: "pilosity of post-anal tail" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003693 ! post-anal tail morphology is_a: PATO:0000066 ! pilosity intersection_of: PATO:0000066 ! pilosity -intersection_of: inheres_in UBERON:0007812 ! post-anal tail +intersection_of: RO:0000052 UBERON:0007812 ! inheres in post-anal tail [Term] id: OBA:0005030 @@ -147729,8 +247084,8 @@ def: "The morphology of a vibrissa follicle." [AUTO:patterns/patterns/entity_att synonym: "morphology of vibrissa follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002076 ! hair follicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010419 ! vibrissa follicle -relationship: inheres_in UBERON:0010419 ! vibrissa follicle +intersection_of: RO:0000052 UBERON:0010419 ! inheres in vibrissa follicle +relationship: RO:0000052 UBERON:0010419 ! inheres in vibrissa follicle [Term] id: OBA:0005031 @@ -147739,8 +247094,8 @@ def: "The morphology of a inner limiting layer of retina." [AUTO:patterns/patter synonym: "morphology of inner limiting layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001794 ! inner limiting layer of retina -relationship: inheres_in UBERON:0001794 ! inner limiting layer of retina +intersection_of: RO:0000052 UBERON:0001794 ! inheres in inner limiting layer of retina +relationship: RO:0000052 UBERON:0001794 ! inheres in inner limiting layer of retina [Term] id: OBA:0005032 @@ -147749,8 +247104,8 @@ def: "The morphology of a outer limiting layer of retina." [AUTO:patterns/patter synonym: "morphology of outer limiting layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001788 ! outer limiting layer of retina -relationship: inheres_in UBERON:0001788 ! outer limiting layer of retina +intersection_of: RO:0000052 UBERON:0001788 ! inheres in outer limiting layer of retina +relationship: RO:0000052 UBERON:0001788 ! inheres in outer limiting layer of retina [Term] id: OBA:0005033 @@ -147760,8 +247115,8 @@ synonym: "morphology of spleen perifollicular zone" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005353 ! spleen perifollicular zone -relationship: inheres_in UBERON:0005353 ! spleen perifollicular zone +intersection_of: RO:0000052 UBERON:0005353 ! inheres in spleen perifollicular zone +relationship: RO:0000052 UBERON:0005353 ! inheres in spleen perifollicular zone [Term] id: OBA:0005034 @@ -147771,7 +247126,7 @@ synonym: "amount of lactation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001882 ! lactation trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0007595 ! lactation +intersection_of: RO:0000052 GO:0007595 ! inheres in lactation [Term] id: OBA:0005035 @@ -147781,8 +247136,8 @@ synonym: "amount of cortex of thymus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002123 ! cortex of thymus -relationship: inheres_in UBERON:0002123 ! cortex of thymus +intersection_of: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus +relationship: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus [Term] id: OBA:0005036 @@ -147792,8 +247147,8 @@ synonym: "morphology of malleus processus brevis" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005354 ! malleus processus brevis -relationship: inheres_in UBERON:0005354 ! malleus processus brevis +intersection_of: RO:0000052 UBERON:0005354 ! inheres in malleus processus brevis +relationship: RO:0000052 UBERON:0005354 ! inheres in malleus processus brevis [Term] id: OBA:0005037 @@ -147803,8 +247158,8 @@ synonym: "morphology of malleus head" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005342 ! malleus head -relationship: inheres_in UBERON:0005342 ! malleus head +intersection_of: RO:0000052 UBERON:0005342 ! inheres in malleus head +relationship: RO:0000052 UBERON:0005342 ! inheres in malleus head [Term] id: OBA:0005038 @@ -147814,8 +247169,8 @@ synonym: "morphology of malleus neck" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005355 ! malleus neck -relationship: inheres_in UBERON:0005355 ! malleus neck +intersection_of: RO:0000052 UBERON:0005355 ! inheres in malleus neck +relationship: RO:0000052 UBERON:0005355 ! inheres in malleus neck [Term] id: OBA:0005039 @@ -147825,7 +247180,7 @@ synonym: "size of malleus neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005038 ! malleus neck morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005355 ! malleus neck +intersection_of: RO:0000052 UBERON:0005355 ! inheres in malleus neck [Term] id: OBA:0005040 @@ -147835,7 +247190,7 @@ synonym: "structure of pharyngeal arch 1" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0004228 ! pharyngeal arch 1 morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004362 ! pharyngeal arch 1 +intersection_of: RO:0000052 UBERON:0004362 ! inheres in pharyngeal arch 1 [Term] id: OBA:0005041 @@ -147844,8 +247199,8 @@ def: "The morphology of a pharyngeal arch artery 1." [AUTO:patterns/patterns/ent synonym: "morphology of pharyngeal arch artery 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003118 ! pharyngeal arch artery 1 -relationship: inheres_in UBERON:0003118 ! pharyngeal arch artery 1 +intersection_of: RO:0000052 UBERON:0003118 ! inheres in pharyngeal arch artery 1 +relationship: RO:0000052 UBERON:0003118 ! inheres in pharyngeal arch artery 1 [Term] id: OBA:0005042 @@ -147854,8 +247209,8 @@ def: "The morphology of a pharyngeal arch artery 2." [AUTO:patterns/patterns/ent synonym: "morphology of pharyngeal arch artery 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003119 ! pharyngeal arch artery 2 -relationship: inheres_in UBERON:0003119 ! pharyngeal arch artery 2 +intersection_of: RO:0000052 UBERON:0003119 ! inheres in pharyngeal arch artery 2 +relationship: RO:0000052 UBERON:0003119 ! inheres in pharyngeal arch artery 2 [Term] id: OBA:0005043 @@ -147865,7 +247220,7 @@ synonym: "functionality of lymphatic part of lymphoid system" EXACT [AUTO:patter is_a: OBA:1000506 ! lymphatic part of lymphoid system quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0006558 ! lymphatic part of lymphoid system +intersection_of: RO:0000052 UBERON:0006558 ! inheres in lymphatic part of lymphoid system [Term] id: OBA:0005044 @@ -147875,8 +247230,8 @@ synonym: "morphology of throat" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000341 ! throat -relationship: inheres_in UBERON:0000341 ! throat +intersection_of: RO:0000052 UBERON:0000341 ! inheres in throat +relationship: RO:0000052 UBERON:0000341 ! inheres in throat [Term] id: OBA:0005045 @@ -147885,8 +247240,8 @@ def: "The morphology of a glycinergic neuron." [AUTO:patterns/patterns/entity_at synonym: "morphology of glycinergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001509 ! glycinergic neuron -relationship: inheres_in CL:1001509 ! glycinergic neuron +intersection_of: RO:0000052 CL:1001509 ! inheres in glycinergic neuron +relationship: RO:0000052 CL:1001509 ! inheres in glycinergic neuron [Term] id: OBA:0005046 @@ -147895,8 +247250,8 @@ def: "The morphology of a Bergmann glial cell." [AUTO:patterns/patterns/entity_a synonym: "morphology of Bergmann glial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002182 ! astrocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000644 ! Bergmann glial cell -relationship: inheres_in CL:0000644 ! Bergmann glial cell +intersection_of: RO:0000052 CL:0000644 ! inheres in Bergmann glial cell +relationship: RO:0000052 CL:0000644 ! inheres in Bergmann glial cell [Term] id: OBA:0005047 @@ -147906,8 +247261,8 @@ synonym: "displaced of pharyngeal arch" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0002539 ! pharyngeal arch -relationship: inheres_in UBERON:0002539 ! pharyngeal arch +intersection_of: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch +relationship: RO:0000052 UBERON:0002539 ! inheres in pharyngeal arch [Term] id: OBA:0005048 @@ -147917,7 +247272,7 @@ synonym: "amount of interatrial septum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000157 ! interatrial septum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002085 ! interatrial septum +intersection_of: RO:0000052 UBERON:0002085 ! inheres in interatrial septum [Term] id: OBA:0005049 @@ -147926,8 +247281,8 @@ def: "The morphology of a outflow part of right ventricle." [AUTO:patterns/patte synonym: "morphology of outflow part of right ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000135 ! outflow tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005953 ! outflow part of right ventricle -relationship: inheres_in UBERON:0005953 ! outflow part of right ventricle +intersection_of: RO:0000052 UBERON:0005953 ! inheres in outflow part of right ventricle +relationship: RO:0000052 UBERON:0005953 ! inheres in outflow part of right ventricle [Term] id: OBA:0005050 @@ -147937,7 +247292,7 @@ synonym: "morphology of outflow part of left ventricle" EXACT [AUTO:patterns/pat is_a: OBA:1000444 ! outflow part of left ventricle quality is_a: OBA:VT0000135 ! outflow tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005956 ! outflow part of left ventricle +intersection_of: RO:0000052 UBERON:0005956 ! inheres in outflow part of left ventricle [Term] id: OBA:0005051 @@ -147947,7 +247302,7 @@ synonym: "amount of interventricular septum" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000639 ! interventricular septum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:0005052 @@ -147958,7 +247313,7 @@ is_a: OBA:0005089 ! coronary vessel morphology is_a: OBA:1000517 ! coronary sinus quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005438 ! coronary sinus +intersection_of: RO:0000052 UBERON:0005438 ! inheres in coronary sinus [Term] id: OBA:0005053 @@ -147968,7 +247323,7 @@ synonym: "amount of coronary sinus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005093 ! coronary vessel amount is_a: OBA:1000517 ! coronary sinus quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005438 ! coronary sinus +intersection_of: RO:0000052 UBERON:0005438 ! inheres in coronary sinus [Term] id: OBA:0005054 @@ -147978,7 +247333,7 @@ synonym: "structure of pulmonary vein" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003463 ! blood vessel structure is_a: OBA:VT0002726 ! pulmonary vein morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002016 ! pulmonary vein +intersection_of: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein [Term] id: OBA:0005055 @@ -147987,8 +247342,8 @@ def: "The morphology of a hepatic vein." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of hepatic vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001143 ! hepatic vein -relationship: inheres_in UBERON:0001143 ! hepatic vein +intersection_of: RO:0000052 UBERON:0001143 ! inheres in hepatic vein +relationship: RO:0000052 UBERON:0001143 ! inheres in hepatic vein [Term] id: OBA:0005056 @@ -147998,7 +247353,7 @@ synonym: "structure of outflow part of left ventricle" EXACT [AUTO:patterns/patt is_a: OBA:0005050 ! outflow part of left ventricle morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0005956 ! outflow part of left ventricle +intersection_of: RO:0000052 UBERON:0005956 ! inheres in outflow part of left ventricle [Term] id: OBA:0005057 @@ -148008,7 +247363,7 @@ synonym: "structure of outflow part of right ventricle" EXACT [AUTO:patterns/pat is_a: OBA:0005049 ! outflow part of right ventricle morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0005953 ! outflow part of right ventricle +intersection_of: RO:0000052 UBERON:0005953 ! inheres in outflow part of right ventricle [Term] id: OBA:0005058 @@ -148018,8 +247373,8 @@ synonym: "morphology of cardiac vein" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0005089 ! coronary vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004148 ! cardiac vein -relationship: inheres_in UBERON:0004148 ! cardiac vein +intersection_of: RO:0000052 UBERON:0004148 ! inheres in cardiac vein +relationship: RO:0000052 UBERON:0004148 ! inheres in cardiac vein [Term] id: OBA:0005059 @@ -148029,7 +247384,7 @@ synonym: "size of pulmonary trunk" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000032 ! blood vessel size is_a: OBA:0003510 ! pulmonary trunk morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002333 ! pulmonary trunk +intersection_of: RO:0000052 UBERON:0002333 ! inheres in pulmonary trunk [Term] id: OBA:0005060 @@ -148039,8 +247394,8 @@ synonym: "occurrence of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery -relationship: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery +relationship: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:0005061 @@ -148050,7 +247405,7 @@ synonym: "structure of ascending aorta" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004883 ! ascending aorta morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001496 ! ascending aorta +intersection_of: RO:0000052 UBERON:0001496 ! inheres in ascending aorta [Term] id: OBA:0005062 @@ -148060,7 +247415,7 @@ synonym: "size of descending aorta" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004885 ! descending aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001514 ! descending aorta +intersection_of: RO:0000052 UBERON:0001514 ! inheres in descending aorta [Term] id: OBA:0005063 @@ -148070,8 +247425,8 @@ synonym: "morphology of sinus of Valsalva" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003707 ! sinus of Valsalva -relationship: inheres_in UBERON:0003707 ! sinus of Valsalva +intersection_of: RO:0000052 UBERON:0003707 ! inheres in sinus of Valsalva +relationship: RO:0000052 UBERON:0003707 ! inheres in sinus of Valsalva [Term] id: OBA:0005064 @@ -148081,7 +247436,7 @@ synonym: "size of pharyngeal arch artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004363 ! pharyngeal arch artery +intersection_of: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery [Term] id: OBA:0005065 @@ -148091,8 +247446,8 @@ synonym: "amount of right subclavian artery" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001534 ! right subclavian artery -relationship: inheres_in UBERON:0001534 ! right subclavian artery +intersection_of: RO:0000052 UBERON:0001534 ! inheres in right subclavian artery +relationship: RO:0000052 UBERON:0001534 ! inheres in right subclavian artery [Term] id: OBA:0005066 @@ -148101,8 +247456,8 @@ def: "The morphology of a right subclavian artery." [AUTO:patterns/patterns/enti synonym: "morphology of right subclavian artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003812 ! subclavian artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001534 ! right subclavian artery -relationship: inheres_in UBERON:0001534 ! right subclavian artery +intersection_of: RO:0000052 UBERON:0001534 ! inheres in right subclavian artery +relationship: RO:0000052 UBERON:0001534 ! inheres in right subclavian artery [Term] id: OBA:0005067 @@ -148111,8 +247466,8 @@ def: "The morphology of a left subclavian artery." [AUTO:patterns/patterns/entit synonym: "morphology of left subclavian artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003812 ! subclavian artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001584 ! left subclavian artery -relationship: inheres_in UBERON:0001584 ! left subclavian artery +intersection_of: RO:0000052 UBERON:0001584 ! inheres in left subclavian artery +relationship: RO:0000052 UBERON:0001584 ! inheres in left subclavian artery [Term] id: OBA:0005068 @@ -148121,8 +247476,8 @@ def: "The morphology of a valve of inferior vena cava." [AUTO:patterns/patterns/ synonym: "morphology of valve of inferior vena cava" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005485 ! valve of inferior vena cava -relationship: inheres_in UBERON:0005485 ! valve of inferior vena cava +intersection_of: RO:0000052 UBERON:0005485 ! inheres in valve of inferior vena cava +relationship: RO:0000052 UBERON:0005485 ! inheres in valve of inferior vena cava [Term] id: OBA:0005069 @@ -148131,8 +247486,8 @@ def: "The morphology of a coronary sinus valve." [AUTO:patterns/patterns/entity_ synonym: "morphology of coronary sinus valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004150 ! coronary sinus valve -relationship: inheres_in UBERON:0004150 ! coronary sinus valve +intersection_of: RO:0000052 UBERON:0004150 ! inheres in coronary sinus valve +relationship: RO:0000052 UBERON:0004150 ! inheres in coronary sinus valve [Term] id: OBA:0005070 @@ -148141,8 +247496,8 @@ def: "The morphology of a endocardium of atrium." [AUTO:patterns/patterns/entity synonym: "morphology of endocardium of atrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003974 ! endocardium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002166 ! endocardium of atrium -relationship: inheres_in UBERON:0002166 ! endocardium of atrium +intersection_of: RO:0000052 UBERON:0002166 ! inheres in endocardium of atrium +relationship: RO:0000052 UBERON:0002166 ! inheres in endocardium of atrium [Term] id: OBA:0005071 @@ -148151,8 +247506,8 @@ def: "The morphology of a myocardium of atrium." [AUTO:patterns/patterns/entity_ synonym: "morphology of myocardium of atrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005329 ! heart muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002302 ! myocardium of atrium -relationship: inheres_in UBERON:0002302 ! myocardium of atrium +intersection_of: RO:0000052 UBERON:0002302 ! inheres in myocardium of atrium +relationship: RO:0000052 UBERON:0002302 ! inheres in myocardium of atrium [Term] id: OBA:0005072 @@ -148161,8 +247516,8 @@ def: "The morphology of a endocardium of ventricle." [AUTO:patterns/patterns/ent synonym: "morphology of endocardium of ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003974 ! endocardium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001081 ! endocardium of ventricle -relationship: inheres_in UBERON:0001081 ! endocardium of ventricle +intersection_of: RO:0000052 UBERON:0001081 ! inheres in endocardium of ventricle +relationship: RO:0000052 UBERON:0001081 ! inheres in endocardium of ventricle [Term] id: OBA:0005073 @@ -148172,8 +247527,8 @@ synonym: "morphology of crista terminalis" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005979 ! crista terminalis -relationship: inheres_in UBERON:0005979 ! crista terminalis +intersection_of: RO:0000052 UBERON:0005979 ! inheres in crista terminalis +relationship: RO:0000052 UBERON:0005979 ! inheres in crista terminalis [Term] id: OBA:0005074 @@ -148183,8 +247538,8 @@ synonym: "morphology of pectinate muscle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005980 ! pectinate muscle -relationship: inheres_in UBERON:0005980 ! pectinate muscle +intersection_of: RO:0000052 UBERON:0005980 ! inheres in pectinate muscle +relationship: RO:0000052 UBERON:0005980 ! inheres in pectinate muscle [Term] id: OBA:0005075 @@ -148194,8 +247549,8 @@ synonym: "morphology of vena cava sinus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005981 ! vena cava sinus -relationship: inheres_in UBERON:0005981 ! vena cava sinus +intersection_of: RO:0000052 UBERON:0005981 ! inheres in vena cava sinus +relationship: RO:0000052 UBERON:0005981 ! inheres in vena cava sinus [Term] id: OBA:0005076 @@ -148205,8 +247560,8 @@ synonym: "morphology of interventricular septum muscular part" EXACT [AUTO:patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004667 ! interventricular septum muscular part -relationship: inheres_in UBERON:0004667 ! interventricular septum muscular part +intersection_of: RO:0000052 UBERON:0004667 ! inheres in interventricular septum muscular part +relationship: RO:0000052 UBERON:0004667 ! inheres in interventricular septum muscular part [Term] id: OBA:0005077 @@ -148215,8 +247570,8 @@ def: "The morphology of a myocardium of ventricle." [AUTO:patterns/patterns/enti synonym: "morphology of myocardium of ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005329 ! heart muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001083 ! myocardium of ventricle -relationship: inheres_in UBERON:0001083 ! myocardium of ventricle +intersection_of: RO:0000052 UBERON:0001083 ! inheres in myocardium of ventricle +relationship: RO:0000052 UBERON:0001083 ! inheres in myocardium of ventricle [Term] id: OBA:0005078 @@ -148226,7 +247581,7 @@ synonym: "size of myocardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005329 ! heart muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:0005079 @@ -148236,7 +247591,7 @@ synonym: "size of myocardium of ventricle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005077 ! myocardium of ventricle morphology is_a: OBA:0005078 ! myocardium size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001083 ! myocardium of ventricle +intersection_of: RO:0000052 UBERON:0001083 ! inheres in myocardium of ventricle [Term] id: OBA:0005080 @@ -148245,8 +247600,8 @@ def: "The morphology of a Bachmann's bundle." [AUTO:patterns/patterns/entity_att synonym: "morphology of Bachmann's bundle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005982 ! Bachmann's bundle -relationship: inheres_in UBERON:0005982 ! Bachmann's bundle +intersection_of: RO:0000052 UBERON:0005982 ! inheres in Bachmann's bundle +relationship: RO:0000052 UBERON:0005982 ! inheres in Bachmann's bundle [Term] id: OBA:0005081 @@ -148256,7 +247611,7 @@ synonym: "size of atrioventricular node" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003726 ! cardiac muscle tissue of myocardium size is_a: OBA:VT0004114 ! atrioventricular node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002352 ! atrioventricular node +intersection_of: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node [Term] id: OBA:0005082 @@ -148265,8 +247620,8 @@ def: "The size of a right ventricle myocardium." [AUTO:patterns/patterns/entity_ synonym: "size of right ventricle myocardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005079 ! myocardium of ventricle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006567 ! right ventricle myocardium -relationship: inheres_in UBERON:0006567 ! right ventricle myocardium +intersection_of: RO:0000052 UBERON:0006567 ! inheres in right ventricle myocardium +relationship: RO:0000052 UBERON:0006567 ! inheres in right ventricle myocardium [Term] id: OBA:0005083 @@ -148276,7 +247631,7 @@ synonym: "closure of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003467 ! blood vessel closure is_a: OBA:VT0000272 ! aorta morphology trait intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:0005084 @@ -148286,8 +247641,8 @@ synonym: "morphology of heart layer" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005983 ! heart layer -relationship: inheres_in UBERON:0005983 ! heart layer +intersection_of: RO:0000052 UBERON:0005983 ! inheres in heart layer +relationship: RO:0000052 UBERON:0005983 ! inheres in heart layer [Term] id: OBA:0005085 @@ -148296,8 +247651,8 @@ def: "The morphology of a subendocardium layer." [AUTO:patterns/patterns/entity_ synonym: "morphology of subendocardium layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005984 ! subendocardium layer -relationship: inheres_in UBERON:0005984 ! subendocardium layer +intersection_of: RO:0000052 UBERON:0005984 ! inheres in subendocardium layer +relationship: RO:0000052 UBERON:0005984 ! inheres in subendocardium layer [Term] id: OBA:0005086 @@ -148307,8 +247662,8 @@ synonym: "morphology of mesocardium" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010277 ! mesocardium -relationship: inheres_in UBERON:0010277 ! mesocardium +intersection_of: RO:0000052 UBERON:0010277 ! inheres in mesocardium +relationship: RO:0000052 UBERON:0010277 ! inheres in mesocardium [Term] id: OBA:0005087 @@ -148317,8 +247672,8 @@ def: "The morphology of a dorsal mesocardium." [AUTO:patterns/patterns/entity_at synonym: "morphology of dorsal mesocardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005086 ! mesocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005601 ! dorsal mesocardium -relationship: inheres_in UBERON:0005601 ! dorsal mesocardium +intersection_of: RO:0000052 UBERON:0005601 ! inheres in dorsal mesocardium +relationship: RO:0000052 UBERON:0005601 ! inheres in dorsal mesocardium [Term] id: OBA:0005088 @@ -148328,8 +247683,8 @@ synonym: "amount of dorsal mesocardium" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005601 ! dorsal mesocardium -relationship: inheres_in UBERON:0005601 ! dorsal mesocardium +intersection_of: RO:0000052 UBERON:0005601 ! inheres in dorsal mesocardium +relationship: RO:0000052 UBERON:0005601 ! inheres in dorsal mesocardium [Term] id: OBA:0005089 @@ -148339,8 +247694,8 @@ synonym: "morphology of coronary vessel" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005985 ! coronary vessel -relationship: inheres_in UBERON:0005985 ! coronary vessel +intersection_of: RO:0000052 UBERON:0005985 ! inheres in coronary vessel +relationship: RO:0000052 UBERON:0005985 ! inheres in coronary vessel [Term] id: OBA:0005090 @@ -148350,8 +247705,8 @@ synonym: "amount of epicardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002348 ! epicardium -relationship: inheres_in UBERON:0002348 ! epicardium +intersection_of: RO:0000052 UBERON:0002348 ! inheres in epicardium +relationship: RO:0000052 UBERON:0002348 ! inheres in epicardium [Term] id: OBA:0005091 @@ -148360,8 +247715,8 @@ def: "The size of a compact layer of ventricle." [AUTO:patterns/patterns/entity_ synonym: "size of compact layer of ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003904 ! myocardial compact layer size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004127 ! compact layer of ventricle -relationship: inheres_in UBERON:0004127 ! compact layer of ventricle +intersection_of: RO:0000052 UBERON:0004127 ! inheres in compact layer of ventricle +relationship: RO:0000052 UBERON:0004127 ! inheres in compact layer of ventricle [Term] id: OBA:0005092 @@ -148371,7 +247726,7 @@ synonym: "size of sinus venosus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003228 ! sinus venosus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002063 ! sinus venosus +intersection_of: RO:0000052 UBERON:0002063 ! inheres in sinus venosus [Term] id: OBA:0005093 @@ -148381,8 +247736,8 @@ synonym: "amount of coronary vessel" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005985 ! coronary vessel -relationship: inheres_in UBERON:0005985 ! coronary vessel +intersection_of: RO:0000052 UBERON:0005985 ! inheres in coronary vessel +relationship: RO:0000052 UBERON:0005985 ! inheres in coronary vessel [Term] id: OBA:0005094 @@ -148392,8 +247747,8 @@ synonym: "amount of sinus venosus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002063 ! sinus venosus -relationship: inheres_in UBERON:0002063 ! sinus venosus +intersection_of: RO:0000052 UBERON:0002063 ! inheres in sinus venosus +relationship: RO:0000052 UBERON:0002063 ! inheres in sinus venosus [Term] id: OBA:0005095 @@ -148403,8 +247758,8 @@ synonym: "morphology of ductus arteriosus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005089 ! coronary vessel morphology is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005440 ! ductus arteriosus -relationship: inheres_in UBERON:0005440 ! ductus arteriosus +intersection_of: RO:0000052 UBERON:0005440 ! inheres in ductus arteriosus +relationship: RO:0000052 UBERON:0005440 ! inheres in ductus arteriosus [Term] id: OBA:0005096 @@ -148413,8 +247768,8 @@ def: "The amount of a ductus arteriosus." [AUTO:patterns/patterns/entity_attribu synonym: "amount of ductus arteriosus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005093 ! coronary vessel amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005440 ! ductus arteriosus -relationship: inheres_in UBERON:0005440 ! ductus arteriosus +intersection_of: RO:0000052 UBERON:0005440 ! inheres in ductus arteriosus +relationship: RO:0000052 UBERON:0005440 ! inheres in ductus arteriosus [Term] id: OBA:0005097 @@ -148423,8 +247778,8 @@ def: "The morphology of a left bundle branch." [AUTO:patterns/patterns/entity_at synonym: "morphology of left bundle branch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005986 ! left bundle branch -relationship: inheres_in UBERON:0005986 ! left bundle branch +intersection_of: RO:0000052 UBERON:0005986 ! inheres in left bundle branch +relationship: RO:0000052 UBERON:0005986 ! inheres in left bundle branch [Term] id: OBA:0005098 @@ -148433,8 +247788,8 @@ def: "The morphology of a right bundle branch." [AUTO:patterns/patterns/entity_a synonym: "morphology of right bundle branch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005987 ! right bundle branch -relationship: inheres_in UBERON:0005987 ! right bundle branch +intersection_of: RO:0000052 UBERON:0005987 ! inheres in right bundle branch +relationship: RO:0000052 UBERON:0005987 ! inheres in right bundle branch [Term] id: OBA:0005099 @@ -148444,8 +247799,8 @@ synonym: "morphology of bulbus cordis" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004706 ! bulbus cordis -relationship: inheres_in UBERON:0004706 ! bulbus cordis +intersection_of: RO:0000052 UBERON:0004706 ! inheres in bulbus cordis +relationship: RO:0000052 UBERON:0004706 ! inheres in bulbus cordis [Term] id: OBA:0005100 @@ -148455,8 +247810,8 @@ synonym: "morphology of atrium myocardial trabecula" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005988 ! atrium myocardial trabecula -relationship: inheres_in UBERON:0005988 ! atrium myocardial trabecula +intersection_of: RO:0000052 UBERON:0005988 ! inheres in atrium myocardial trabecula +relationship: RO:0000052 UBERON:0005988 ! inheres in atrium myocardial trabecula [Term] id: OBA:0005101 @@ -148466,8 +247821,8 @@ synonym: "morphology of conotruncus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006060 ! conotruncus -relationship: inheres_in UBERON:0006060 ! conotruncus +intersection_of: RO:0000052 UBERON:0006060 ! inheres in conotruncus +relationship: RO:0000052 UBERON:0006060 ! inheres in conotruncus [Term] id: OBA:0005102 @@ -148477,8 +247832,8 @@ synonym: "morphology of conotruncal ridge" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0005373 ! cardiac mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005967 ! conotruncal ridge -relationship: inheres_in UBERON:0005967 ! conotruncal ridge +intersection_of: RO:0000052 UBERON:0005967 ! inheres in conotruncal ridge +relationship: RO:0000052 UBERON:0005967 ! inheres in conotruncal ridge [Term] id: OBA:0005103 @@ -148488,8 +247843,8 @@ synonym: "amount of conotruncal ridge" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005967 ! conotruncal ridge -relationship: inheres_in UBERON:0005967 ! conotruncal ridge +intersection_of: RO:0000052 UBERON:0005967 ! inheres in conotruncal ridge +relationship: RO:0000052 UBERON:0005967 ! inheres in conotruncal ridge [Term] id: OBA:0005104 @@ -148499,7 +247854,7 @@ synonym: "size of conotruncal ridge" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005102 ! conotruncal ridge morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005967 ! conotruncal ridge +intersection_of: RO:0000052 UBERON:0005967 ! inheres in conotruncal ridge [Term] id: OBA:0005105 @@ -148509,7 +247864,7 @@ synonym: "size of aortic valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003470 ! cardial valve size is_a: OBA:VT0000040 ! aortic valve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:0005106 @@ -148518,8 +247873,8 @@ def: "The morphology of a atrioventricular septum." [AUTO:patterns/patterns/enti synonym: "morphology of atrioventricular septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006113 ! heart septum morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005989 ! atrioventricular septum -relationship: inheres_in UBERON:0005989 ! atrioventricular septum +intersection_of: RO:0000052 UBERON:0005989 ! inheres in atrioventricular septum +relationship: RO:0000052 UBERON:0005989 ! inheres in atrioventricular septum [Term] id: OBA:0005107 @@ -148528,8 +247883,8 @@ def: "The size of a aortic valve leaflet." [AUTO:patterns/patterns/entity_attrib synonym: "size of aortic valve leaflet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011742 ! aortic valve leaflet -relationship: inheres_in UBERON:0011742 ! aortic valve leaflet +intersection_of: RO:0000052 UBERON:0011742 ! inheres in aortic valve leaflet +relationship: RO:0000052 UBERON:0011742 ! inheres in aortic valve leaflet [Term] id: OBA:0005108 @@ -148539,8 +247894,8 @@ synonym: "morphology of aortic valve cusp" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005990 ! aortic valve cusp -relationship: inheres_in UBERON:0005990 ! aortic valve cusp +intersection_of: RO:0000052 UBERON:0005990 ! inheres in aortic valve cusp +relationship: RO:0000052 UBERON:0005990 ! inheres in aortic valve cusp [Term] id: OBA:0005109 @@ -148550,8 +247905,8 @@ synonym: "amount of aortic valve cusp" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005990 ! aortic valve cusp -relationship: inheres_in UBERON:0005990 ! aortic valve cusp +intersection_of: RO:0000052 UBERON:0005990 ! inheres in aortic valve cusp +relationship: RO:0000052 UBERON:0005990 ! inheres in aortic valve cusp [Term] id: OBA:0005110 @@ -148560,8 +247915,8 @@ def: "The morphology of a aortic valve anulus." [AUTO:patterns/patterns/entity_a synonym: "morphology of aortic valve anulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004270 ! fibrocartilage morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005991 ! aortic valve anulus -relationship: inheres_in UBERON:0005991 ! aortic valve anulus +intersection_of: RO:0000052 UBERON:0005991 ! inheres in aortic valve anulus +relationship: RO:0000052 UBERON:0005991 ! inheres in aortic valve anulus [Term] id: OBA:0005111 @@ -148571,7 +247926,7 @@ synonym: "size of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003470 ! cardial valve size is_a: OBA:VT0000044 ! pulmonary valve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:0005112 @@ -148581,8 +247936,8 @@ synonym: "morphology of pulmonary valve cusp" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005992 ! pulmonary valve cusp -relationship: inheres_in UBERON:0005992 ! pulmonary valve cusp +intersection_of: RO:0000052 UBERON:0005992 ! inheres in pulmonary valve cusp +relationship: RO:0000052 UBERON:0005992 ! inheres in pulmonary valve cusp [Term] id: OBA:0005113 @@ -148592,8 +247947,8 @@ synonym: "amount of pulmonary valve cusp" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005992 ! pulmonary valve cusp -relationship: inheres_in UBERON:0005992 ! pulmonary valve cusp +intersection_of: RO:0000052 UBERON:0005992 ! inheres in pulmonary valve cusp +relationship: RO:0000052 UBERON:0005992 ! inheres in pulmonary valve cusp [Term] id: OBA:0005114 @@ -148602,8 +247957,8 @@ def: "The size of a pulmonary valve leaflets." [AUTO:patterns/patterns/entity_at synonym: "size of pulmonary valve leaflets" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011745 ! pulmonary valve leaflets -relationship: inheres_in UBERON:0011745 ! pulmonary valve leaflets +intersection_of: RO:0000052 UBERON:0011745 ! inheres in pulmonary valve leaflets +relationship: RO:0000052 UBERON:0011745 ! inheres in pulmonary valve leaflets [Term] id: OBA:0005115 @@ -148612,8 +247967,8 @@ def: "The morphology of a pulmonary valve anulus." [AUTO:patterns/patterns/entit synonym: "morphology of pulmonary valve anulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004270 ! fibrocartilage morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005993 ! pulmonary valve anulus -relationship: inheres_in UBERON:0005993 ! pulmonary valve anulus +intersection_of: RO:0000052 UBERON:0005993 ! inheres in pulmonary valve anulus +relationship: RO:0000052 UBERON:0005993 ! inheres in pulmonary valve anulus [Term] id: OBA:0005116 @@ -148622,8 +247977,8 @@ def: "The morphology of a chorda tendineae." [AUTO:patterns/patterns/entity_attr synonym: "morphology of chorda tendineae" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005994 ! chorda tendineae -relationship: inheres_in UBERON:0005994 ! chorda tendineae +intersection_of: RO:0000052 UBERON:0005994 ! inheres in chorda tendineae +relationship: RO:0000052 UBERON:0005994 ! inheres in chorda tendineae [Term] id: OBA:0005117 @@ -148633,8 +247988,8 @@ synonym: "amount of chorda tendineae" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005994 ! chorda tendineae -relationship: inheres_in UBERON:0005994 ! chorda tendineae +intersection_of: RO:0000052 UBERON:0005994 ! inheres in chorda tendineae +relationship: RO:0000052 UBERON:0005994 ! inheres in chorda tendineae [Term] id: OBA:0005118 @@ -148643,8 +247998,8 @@ def: "The morphology of a mitral valve anulus." [AUTO:patterns/patterns/entity_a synonym: "morphology of mitral valve anulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004270 ! fibrocartilage morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005995 ! mitral valve anulus -relationship: inheres_in UBERON:0005995 ! mitral valve anulus +intersection_of: RO:0000052 UBERON:0005995 ! inheres in mitral valve anulus +relationship: RO:0000052 UBERON:0005995 ! inheres in mitral valve anulus [Term] id: OBA:0005119 @@ -148654,8 +248009,8 @@ synonym: "morphology of mitral valve cusp" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005996 ! mitral valve cusp -relationship: inheres_in UBERON:0005996 ! mitral valve cusp +intersection_of: RO:0000052 UBERON:0005996 ! inheres in mitral valve cusp +relationship: RO:0000052 UBERON:0005996 ! inheres in mitral valve cusp [Term] id: OBA:0005120 @@ -148665,8 +248020,8 @@ synonym: "amount of mitral valve cusp" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005996 ! mitral valve cusp -relationship: inheres_in UBERON:0005996 ! mitral valve cusp +intersection_of: RO:0000052 UBERON:0005996 ! inheres in mitral valve cusp +relationship: RO:0000052 UBERON:0005996 ! inheres in mitral valve cusp [Term] id: OBA:0005121 @@ -148675,8 +248030,8 @@ def: "The size of a mitral valve leaflet." [AUTO:patterns/patterns/entity_attrib synonym: "size of mitral valve leaflet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007151 ! mitral valve leaflet -relationship: inheres_in UBERON:0007151 ! mitral valve leaflet +intersection_of: RO:0000052 UBERON:0007151 ! inheres in mitral valve leaflet +relationship: RO:0000052 UBERON:0007151 ! inheres in mitral valve leaflet [Term] id: OBA:0005122 @@ -148686,7 +248041,7 @@ synonym: "size of mitral valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003470 ! cardial valve size is_a: OBA:VT0000033 ! mitral valve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:0005123 @@ -148695,8 +248050,8 @@ def: "The morphology of a tricuspid valve anulus." [AUTO:patterns/patterns/entit synonym: "morphology of tricuspid valve anulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004270 ! fibrocartilage morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005997 ! tricuspid valve anulus -relationship: inheres_in UBERON:0005997 ! tricuspid valve anulus +intersection_of: RO:0000052 UBERON:0005997 ! inheres in tricuspid valve anulus +relationship: RO:0000052 UBERON:0005997 ! inheres in tricuspid valve anulus [Term] id: OBA:0005124 @@ -148706,8 +248061,8 @@ synonym: "morphology of tricuspid valve cusp" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005998 ! tricuspid valve cusp -relationship: inheres_in UBERON:0005998 ! tricuspid valve cusp +intersection_of: RO:0000052 UBERON:0005998 ! inheres in tricuspid valve cusp +relationship: RO:0000052 UBERON:0005998 ! inheres in tricuspid valve cusp [Term] id: OBA:0005125 @@ -148718,7 +248073,7 @@ is_a: OBA:VT0000036 ! tricuspid valve morphology trait is_a: OBA:VT0000285 ! heart valve morphology trait is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0005126 @@ -148728,8 +248083,8 @@ synonym: "amount of tricuspid valve cusp" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005998 ! tricuspid valve cusp -relationship: inheres_in UBERON:0005998 ! tricuspid valve cusp +intersection_of: RO:0000052 UBERON:0005998 ! inheres in tricuspid valve cusp +relationship: RO:0000052 UBERON:0005998 ! inheres in tricuspid valve cusp [Term] id: OBA:0005127 @@ -148738,8 +248093,8 @@ def: "The size of a tricuspid valve leaflet." [AUTO:patterns/patterns/entity_att synonym: "size of tricuspid valve leaflet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005484 ! tricuspid valve leaflet -relationship: inheres_in UBERON:0005484 ! tricuspid valve leaflet +intersection_of: RO:0000052 UBERON:0005484 ! inheres in tricuspid valve leaflet +relationship: RO:0000052 UBERON:0005484 ! inheres in tricuspid valve leaflet [Term] id: OBA:0005128 @@ -148749,7 +248104,7 @@ synonym: "size of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003470 ! cardial valve size is_a: OBA:VT0000036 ! tricuspid valve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:0005129 @@ -148759,8 +248114,8 @@ synonym: "morphology of cardiac muscle tissue of myocardium" EXACT [AUTO:pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004493 ! cardiac muscle tissue of myocardium -relationship: inheres_in UBERON:0004493 ! cardiac muscle tissue of myocardium +intersection_of: RO:0000052 UBERON:0004493 ! inheres in cardiac muscle tissue of myocardium +relationship: RO:0000052 UBERON:0004493 ! inheres in cardiac muscle tissue of myocardium [Term] id: OBA:0005130 @@ -148770,8 +248125,8 @@ synonym: "amount of intercalated disc" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0014704 ! intercalated disc -relationship: inheres_in GO:0014704 ! intercalated disc +intersection_of: RO:0000052 GO:0014704 ! inheres in intercalated disc +relationship: RO:0000052 GO:0014704 ! inheres in intercalated disc [Term] id: OBA:0005131 @@ -148781,7 +248136,7 @@ synonym: "structure of descending aorta" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004885 ! descending aorta morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001514 ! descending aorta +intersection_of: RO:0000052 UBERON:0001514 ! inheres in descending aorta [Term] id: OBA:0005132 @@ -148790,8 +248145,8 @@ def: "The amount of a pharyngeal arch 3." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pharyngeal arch 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003882 ! pharyngeal arch amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003114 ! pharyngeal arch 3 -relationship: inheres_in UBERON:0003114 ! pharyngeal arch 3 +intersection_of: RO:0000052 UBERON:0003114 ! inheres in pharyngeal arch 3 +relationship: RO:0000052 UBERON:0003114 ! inheres in pharyngeal arch 3 [Term] id: OBA:0005133 @@ -148800,8 +248155,8 @@ def: "The amount of a pharyngeal arch 4." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pharyngeal arch 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003882 ! pharyngeal arch amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003115 ! pharyngeal arch 4 -relationship: inheres_in UBERON:0003115 ! pharyngeal arch 4 +intersection_of: RO:0000052 UBERON:0003115 ! inheres in pharyngeal arch 4 +relationship: RO:0000052 UBERON:0003115 ! inheres in pharyngeal arch 4 [Term] id: OBA:0005134 @@ -148810,8 +248165,8 @@ def: "The amount of a pharyngeal arch 6." [AUTO:patterns/patterns/entity_attribu synonym: "amount of pharyngeal arch 6" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003882 ! pharyngeal arch amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003117 ! pharyngeal arch 6 -relationship: inheres_in UBERON:0003117 ! pharyngeal arch 6 +intersection_of: RO:0000052 UBERON:0003117 ! inheres in pharyngeal arch 6 +relationship: RO:0000052 UBERON:0003117 ! inheres in pharyngeal arch 6 [Term] id: OBA:0005135 @@ -148821,7 +248176,7 @@ synonym: "amount of pulmonary vein" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000485 ! pulmonary vein quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002016 ! pulmonary vein +intersection_of: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein [Term] id: OBA:0005136 @@ -148830,8 +248185,8 @@ def: "The morphology of a aortico-pulmonary spiral septum." [AUTO:patterns/patte synonym: "morphology of aortico-pulmonary spiral septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006113 ! heart septum morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006207 ! aortico-pulmonary spiral septum -relationship: inheres_in UBERON:0006207 ! aortico-pulmonary spiral septum +intersection_of: RO:0000052 UBERON:0006207 ! inheres in aortico-pulmonary spiral septum +relationship: RO:0000052 UBERON:0006207 ! inheres in aortico-pulmonary spiral septum [Term] id: OBA:0005137 @@ -148841,8 +248196,8 @@ synonym: "amount of aortico-pulmonary spiral septum" EXACT [AUTO:patterns/patter is_a: OBA:1000251 ! cardiac septum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006207 ! aortico-pulmonary spiral septum -relationship: inheres_in UBERON:0006207 ! aortico-pulmonary spiral septum +intersection_of: RO:0000052 UBERON:0006207 ! inheres in aortico-pulmonary spiral septum +relationship: RO:0000052 UBERON:0006207 ! inheres in aortico-pulmonary spiral septum [Term] id: OBA:0005138 @@ -148852,8 +248207,8 @@ synonym: "amount of cardiac jelly" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003906 ! cardiac jelly -relationship: inheres_in UBERON:0003906 ! cardiac jelly +intersection_of: RO:0000052 UBERON:0003906 ! inheres in cardiac jelly +relationship: RO:0000052 UBERON:0003906 ! inheres in cardiac jelly [Term] id: OBA:0005139 @@ -148863,8 +248218,8 @@ synonym: "amount of pulmonary trunk" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002333 ! pulmonary trunk -relationship: inheres_in UBERON:0002333 ! pulmonary trunk +intersection_of: RO:0000052 UBERON:0002333 ! inheres in pulmonary trunk +relationship: RO:0000052 UBERON:0002333 ! inheres in pulmonary trunk [Term] id: OBA:0005140 @@ -148874,8 +248229,8 @@ synonym: "morphology of intersomitic artery" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0005637 ! intersomitic vessel morphology is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002457 ! intersomitic artery -relationship: inheres_in UBERON:0002457 ! intersomitic artery +intersection_of: RO:0000052 UBERON:0002457 ! inheres in intersomitic artery +relationship: RO:0000052 UBERON:0002457 ! inheres in intersomitic artery [Term] id: OBA:0005141 @@ -148884,8 +248239,8 @@ def: "The morphology of a brachiocephalic artery." [AUTO:patterns/patterns/entit synonym: "morphology of brachiocephalic artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001529 ! brachiocephalic artery -relationship: inheres_in UBERON:0001529 ! brachiocephalic artery +intersection_of: RO:0000052 UBERON:0001529 ! inheres in brachiocephalic artery +relationship: RO:0000052 UBERON:0001529 ! inheres in brachiocephalic artery [Term] id: OBA:0005142 @@ -148894,8 +248249,8 @@ def: "The morphology of a vitelline artery." [AUTO:patterns/patterns/entity_attr synonym: "morphology of vitelline artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006002 ! vitelline artery -relationship: inheres_in UBERON:0006002 ! vitelline artery +intersection_of: RO:0000052 UBERON:0006002 ! inheres in vitelline artery +relationship: RO:0000052 UBERON:0006002 ! inheres in vitelline artery [Term] id: OBA:0005143 @@ -148904,8 +248259,8 @@ def: "The morphology of a vitelline vein." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of vitelline vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005487 ! vitelline vein -relationship: inheres_in UBERON:0005487 ! vitelline vein +intersection_of: RO:0000052 UBERON:0005487 ! inheres in vitelline vein +relationship: RO:0000052 UBERON:0005487 ! inheres in vitelline vein [Term] id: OBA:0005144 @@ -148915,8 +248270,8 @@ synonym: "morphology of umbilical vein" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0005645 ! umbilical blood vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002066 ! umbilical vein -relationship: inheres_in UBERON:0002066 ! umbilical vein +intersection_of: RO:0000052 UBERON:0002066 ! inheres in umbilical vein +relationship: RO:0000052 UBERON:0002066 ! inheres in umbilical vein [Term] id: OBA:0005145 @@ -148925,8 +248280,8 @@ def: "The morphology of a hepatic portal vein." [AUTO:patterns/patterns/entity_a synonym: "morphology of hepatic portal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001639 ! hepatic portal vein -relationship: inheres_in UBERON:0001639 ! hepatic portal vein +intersection_of: RO:0000052 UBERON:0001639 ! inheres in hepatic portal vein +relationship: RO:0000052 UBERON:0001639 ! inheres in hepatic portal vein [Term] id: OBA:0005146 @@ -148935,8 +248290,8 @@ def: "The morphology of a Tc17 cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of Tc17 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004117 ! CD8-positive, alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002128 ! Tc17 cell -relationship: inheres_in CL:0002128 ! Tc17 cell +intersection_of: RO:0000052 CL:0002128 ! inheres in Tc17 cell +relationship: RO:0000052 CL:0002128 ! inheres in Tc17 cell [Term] id: OBA:0005147 @@ -148945,8 +248300,8 @@ def: "The rate of a activation-induced cell death of T cells." [AUTO:patterns/pa synonym: "rate of activation-induced cell death of T cells" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004259 ! T cell apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0006924 ! activation-induced cell death of T cells -relationship: inheres_in GO:0006924 ! activation-induced cell death of T cells +intersection_of: RO:0000052 GO:0006924 ! inheres in activation-induced cell death of T cells +relationship: RO:0000052 GO:0006924 ! inheres in activation-induced cell death of T cells [Term] id: OBA:0005148 @@ -148956,8 +248311,8 @@ synonym: "morphology of integumentary adnexa" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006003 ! integumentary adnexa -relationship: inheres_in UBERON:0006003 ! integumentary adnexa +intersection_of: RO:0000052 UBERON:0006003 ! inheres in integumentary adnexa +relationship: RO:0000052 UBERON:0006003 ! inheres in integumentary adnexa [Term] id: OBA:0005149 @@ -148966,8 +248321,8 @@ def: "The morphology of a arrector muscle of hair." [AUTO:patterns/patterns/enti synonym: "morphology of arrector muscle of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002033 ! arrector muscle of hair -relationship: inheres_in UBERON:0002033 ! arrector muscle of hair +intersection_of: RO:0000052 UBERON:0002033 ! inheres in arrector muscle of hair +relationship: RO:0000052 UBERON:0002033 ! inheres in arrector muscle of hair [Term] id: OBA:0005150 @@ -148977,8 +248332,8 @@ synonym: "functionality of integumentary adnexa" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0006003 ! integumentary adnexa -relationship: inheres_in UBERON:0006003 ! integumentary adnexa +intersection_of: RO:0000052 UBERON:0006003 ! inheres in integumentary adnexa +relationship: RO:0000052 UBERON:0006003 ! inheres in integumentary adnexa [Term] id: OBA:0005151 @@ -148988,8 +248343,8 @@ synonym: "morphology of bulb of hair follicle" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005932 ! bulb of hair follicle -relationship: inheres_in UBERON:0005932 ! bulb of hair follicle +intersection_of: RO:0000052 UBERON:0005932 ! inheres in bulb of hair follicle +relationship: RO:0000052 UBERON:0005932 ! inheres in bulb of hair follicle [Term] id: OBA:0005152 @@ -148999,8 +248354,8 @@ synonym: "morphology of infundibulum of hair follicle" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005968 ! infundibulum of hair follicle -relationship: inheres_in UBERON:0005968 ! infundibulum of hair follicle +intersection_of: RO:0000052 UBERON:0005968 ! inheres in infundibulum of hair follicle +relationship: RO:0000052 UBERON:0005968 ! inheres in infundibulum of hair follicle [Term] id: OBA:0005153 @@ -149010,7 +248365,7 @@ synonym: "size of infundibulum of hair follicle" EXACT [AUTO:patterns/patterns/e is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005152 ! infundibulum of hair follicle morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005968 ! infundibulum of hair follicle +intersection_of: RO:0000052 UBERON:0005968 ! inheres in infundibulum of hair follicle [Term] id: OBA:0005154 @@ -149020,8 +248375,8 @@ synonym: "morphology of hair outer root sheath" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005942 ! hair outer root sheath -relationship: inheres_in UBERON:0005942 ! hair outer root sheath +intersection_of: RO:0000052 UBERON:0005942 ! inheres in hair outer root sheath +relationship: RO:0000052 UBERON:0005942 ! inheres in hair outer root sheath [Term] id: OBA:0005155 @@ -149031,8 +248386,8 @@ synonym: "morphology of hair inner root sheath" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005941 ! hair inner root sheath -relationship: inheres_in UBERON:0005941 ! hair inner root sheath +intersection_of: RO:0000052 UBERON:0005941 ! inheres in hair inner root sheath +relationship: RO:0000052 UBERON:0005941 ! inheres in hair inner root sheath [Term] id: OBA:0005156 @@ -149042,8 +248397,8 @@ synonym: "morphology of hair follicle matrix region" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006004 ! hair follicle matrix region -relationship: inheres_in UBERON:0006004 ! hair follicle matrix region +intersection_of: RO:0000052 UBERON:0006004 ! inheres in hair follicle matrix region +relationship: RO:0000052 UBERON:0006004 ! inheres in hair follicle matrix region [Term] id: OBA:0005157 @@ -149053,7 +248408,7 @@ synonym: "amount of dermal papilla" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000812 ! dermal papilla quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000412 ! dermal papilla +intersection_of: RO:0000052 UBERON:0000412 ! inheres in dermal papilla [Term] id: OBA:0005158 @@ -149063,8 +248418,8 @@ synonym: "morphology of hair follicle isthmus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006005 ! hair follicle isthmus -relationship: inheres_in UBERON:0006005 ! hair follicle isthmus +intersection_of: RO:0000052 UBERON:0006005 ! inheres in hair follicle isthmus +relationship: RO:0000052 UBERON:0006005 ! inheres in hair follicle isthmus [Term] id: OBA:0005159 @@ -149075,7 +248430,7 @@ is_a: OBA:0002829 ! vertebra shape is_a: OBA:0004026 ! vertebral bone 1 morphology is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0000052 UBERON:0001092 ! inheres in vertebral bone 1 [Term] id: OBA:0005160 @@ -149086,7 +248441,7 @@ is_a: OBA:0002829 ! vertebra shape is_a: OBA:0004027 ! vertebral bone 2 morphology is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0001093 ! vertebral bone 2 +intersection_of: RO:0000052 UBERON:0001093 ! inheres in vertebral bone 2 [Term] id: OBA:0005161 @@ -149096,8 +248451,8 @@ synonym: "morphology of optic foramen" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005745 ! optic foramen -relationship: inheres_in UBERON:0005745 ! optic foramen +intersection_of: RO:0000052 UBERON:0005745 ! inheres in optic foramen +relationship: RO:0000052 UBERON:0005745 ! inheres in optic foramen [Term] id: OBA:0005162 @@ -149107,8 +248462,8 @@ synonym: "amount of metoptic pillar" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006006 ! metoptic pillar -relationship: inheres_in UBERON:0006006 ! metoptic pillar +intersection_of: RO:0000052 UBERON:0006006 ! inheres in metoptic pillar +relationship: RO:0000052 UBERON:0006006 ! inheres in metoptic pillar [Term] id: OBA:0005163 @@ -149118,7 +248473,7 @@ synonym: "spatial pattern of lens of camera-type eye" EXACT [AUTO:patterns/patte is_a: OBA:VT0001303 ! lens morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:0005164 @@ -149128,7 +248483,7 @@ synonym: "amount of anterior chamber of eyeball" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000241 ! anterior chamber of eyeball quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001766 ! anterior chamber of eyeball +intersection_of: RO:0000052 UBERON:0001766 ! inheres in anterior chamber of eyeball [Term] id: OBA:0005165 @@ -149138,8 +248493,8 @@ synonym: "amount of sclera" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001773 ! sclera -relationship: inheres_in UBERON:0001773 ! sclera +intersection_of: RO:0000052 UBERON:0001773 ! inheres in sclera +relationship: RO:0000052 UBERON:0001773 ! inheres in sclera [Term] id: OBA:0005166 @@ -149149,8 +248504,8 @@ synonym: "amount of nasolacrimal duct" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002392 ! nasolacrimal duct -relationship: inheres_in UBERON:0002392 ! nasolacrimal duct +intersection_of: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct +relationship: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct [Term] id: OBA:0005167 @@ -149160,8 +248515,8 @@ synonym: "amount of sublingual duct" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001838 ! sublingual duct -relationship: inheres_in UBERON:0001838 ! sublingual duct +intersection_of: RO:0000052 UBERON:0001838 ! inheres in sublingual duct +relationship: RO:0000052 UBERON:0001838 ! inheres in sublingual duct [Term] id: OBA:0005168 @@ -149172,7 +248527,7 @@ is_a: OBA:0003531 ! duct of salivary gland size is_a: OBA:0004762 ! sublingual duct morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001838 ! sublingual duct +intersection_of: RO:0000052 UBERON:0001838 ! inheres in sublingual duct [Term] id: OBA:0005169 @@ -149182,7 +248537,7 @@ synonym: "size of interventricular septum" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0007082 ! ventricle septum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:0005170 @@ -149192,8 +248547,8 @@ synonym: "amount of cervical vertebra 1 arcus anterior" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003996 ! cervical vertebra 1 arcus anterior -relationship: inheres_in UBERON:0003996 ! cervical vertebra 1 arcus anterior +intersection_of: RO:0000052 UBERON:0003996 ! inheres in cervical vertebra 1 arcus anterior +relationship: RO:0000052 UBERON:0003996 ! inheres in cervical vertebra 1 arcus anterior [Term] id: OBA:0005171 @@ -149203,7 +248558,7 @@ synonym: "amount of odontoid process of cervical vertebra 2" EXACT [AUTO:pattern is_a: OBA:1000235 ! odontoid process of cervical vertebra 2 quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004096 ! odontoid process of cervical vertebra 2 +intersection_of: RO:0000052 UBERON:0004096 ! inheres in odontoid process of cervical vertebra 2 [Term] id: OBA:0005172 @@ -149213,7 +248568,7 @@ synonym: "amount of cervical vertebra 1 anterior tubercle" EXACT [AUTO:patterns/ is_a: OBA:1000646 ! cervical vertebra 1 anterior tubercle quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005810 ! cervical vertebra 1 anterior tubercle +intersection_of: RO:0000052 UBERON:0005810 ! inheres in cervical vertebra 1 anterior tubercle [Term] id: OBA:0005173 @@ -149223,8 +248578,8 @@ synonym: "morphology of node of Ranvier" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0033268 ! node of Ranvier -relationship: inheres_in GO:0033268 ! node of Ranvier +intersection_of: RO:0000052 GO:0033268 ! inheres in node of Ranvier +relationship: RO:0000052 GO:0033268 ! inheres in node of Ranvier [Term] id: OBA:0005174 @@ -149234,8 +248589,8 @@ synonym: "morphology of axon initial segment" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0043194 ! axon initial segment -relationship: inheres_in GO:0043194 ! axon initial segment +intersection_of: RO:0000052 GO:0043194 ! inheres in axon initial segment +relationship: RO:0000052 GO:0043194 ! inheres in axon initial segment [Term] id: OBA:0005175 @@ -149245,8 +248600,8 @@ synonym: "morphology of paranode region of axon" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0033270 ! paranode region of axon -relationship: inheres_in GO:0033270 ! paranode region of axon +intersection_of: RO:0000052 GO:0033270 ! inheres in paranode region of axon +relationship: RO:0000052 GO:0033270 ! inheres in paranode region of axon [Term] id: OBA:0005176 @@ -149255,8 +248610,8 @@ def: "The morphology of a extraembryonic ectoderm." [AUTO:patterns/patterns/enti synonym: "morphology of extraembryonic ectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004366 ! extraembryonic ectoderm -relationship: inheres_in UBERON:0004366 ! extraembryonic ectoderm +intersection_of: RO:0000052 UBERON:0004366 ! inheres in extraembryonic ectoderm +relationship: RO:0000052 UBERON:0004366 ! inheres in extraembryonic ectoderm [Term] id: OBA:0005177 @@ -149266,8 +248621,8 @@ synonym: "morphology of juxtaparanode region of axon" EXACT [AUTO:patterns/patte is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0044224 ! juxtaparanode region of axon -relationship: inheres_in GO:0044224 ! juxtaparanode region of axon +intersection_of: RO:0000052 GO:0044224 ! inheres in juxtaparanode region of axon +relationship: RO:0000052 GO:0044224 ! inheres in juxtaparanode region of axon [Term] id: OBA:0005178 @@ -149277,8 +248632,8 @@ synonym: "morphology of internode region of axon" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0033269 ! internode region of axon -relationship: inheres_in GO:0033269 ! internode region of axon +intersection_of: RO:0000052 GO:0033269 ! inheres in internode region of axon +relationship: RO:0000052 GO:0033269 ! inheres in internode region of axon [Term] id: OBA:0005179 @@ -149287,8 +248642,8 @@ def: "The morphology of a axolemma." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of axolemma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000091 ! membrane morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030673 ! axolemma -relationship: inheres_in GO:0030673 ! axolemma +intersection_of: RO:0000052 GO:0030673 ! inheres in axolemma +relationship: RO:0000052 GO:0030673 ! inheres in axolemma [Term] id: OBA:0005180 @@ -149298,8 +248653,8 @@ synonym: "amount of Schwann cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000236 ! glial cell quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002573 ! Schwann cell -relationship: inheres_in CL:0002573 ! Schwann cell +intersection_of: RO:0000052 CL:0002573 ! inheres in Schwann cell +relationship: RO:0000052 CL:0002573 ! inheres in Schwann cell [Term] id: OBA:0005181 @@ -149309,8 +248664,8 @@ synonym: "deviation (from_normal) of cervical flexure" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in UBERON:0005819 ! cervical flexure -relationship: inheres_in UBERON:0005819 ! cervical flexure +intersection_of: RO:0000052 UBERON:0005819 ! inheres in cervical flexure +relationship: RO:0000052 UBERON:0005819 ! inheres in cervical flexure [Term] id: OBA:0005182 @@ -149320,8 +248675,8 @@ synonym: "morphology of pre-Botzinger complex" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006007 ! pre-Botzinger complex -relationship: inheres_in UBERON:0006007 ! pre-Botzinger complex +intersection_of: RO:0000052 UBERON:0006007 ! inheres in pre-Botzinger complex +relationship: RO:0000052 UBERON:0006007 ! inheres in pre-Botzinger complex [Term] id: OBA:0005183 @@ -149331,8 +248686,8 @@ synonym: "functionality of pre-Botzinger complex" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0006007 ! pre-Botzinger complex -relationship: inheres_in UBERON:0006007 ! pre-Botzinger complex +intersection_of: RO:0000052 UBERON:0006007 ! inheres in pre-Botzinger complex +relationship: RO:0000052 UBERON:0006007 ! inheres in pre-Botzinger complex [Term] id: OBA:0005184 @@ -149342,8 +248697,8 @@ synonym: "morphology of tooth enamel organ" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005176 ! tooth enamel organ -relationship: inheres_in UBERON:0005176 ! tooth enamel organ +intersection_of: RO:0000052 UBERON:0005176 ! inheres in tooth enamel organ +relationship: RO:0000052 UBERON:0005176 ! inheres in tooth enamel organ [Term] id: OBA:0005185 @@ -149352,8 +248707,8 @@ def: "The functionality of a hematopoietic stem cell." [AUTO:patterns/patterns/e synonym: "functionality of hematopoietic stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000037 ! hematopoietic stem cell -relationship: inheres_in CL:0000037 ! hematopoietic stem cell +intersection_of: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell +relationship: RO:0000052 CL:0000037 ! inheres in hematopoietic stem cell [Term] id: OBA:0005186 @@ -149363,8 +248718,8 @@ synonym: "occurrence of granulocyte chemotaxis" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0003156 ! leukocyte migration trait is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0071621 ! granulocyte chemotaxis -relationship: inheres_in GO:0071621 ! granulocyte chemotaxis +intersection_of: RO:0000052 GO:0071621 ! inheres in granulocyte chemotaxis +relationship: RO:0000052 GO:0071621 ! inheres in granulocyte chemotaxis [Term] id: OBA:0005187 @@ -149373,8 +248728,8 @@ def: "The deviation (from_normal) of a life span." [AUTO:patterns/patterns/entit synonym: "deviation (from_normal) of life span" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000069 ! deviation (from_normal) -intersection_of: inheres_in PATO:0000050 ! life span -relationship: inheres_in PATO:0000050 ! life span +intersection_of: RO:0000052 PATO:0000050 ! inheres in life span +relationship: RO:0000052 PATO:0000050 ! inheres in life span [Term] id: OBA:0005188 @@ -149383,8 +248738,8 @@ def: "The morphology of a manual digit 1." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of manual digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002110 ! digit morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001463 ! manual digit 1 -relationship: inheres_in UBERON:0001463 ! manual digit 1 +intersection_of: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 +relationship: RO:0000052 UBERON:0001463 ! inheres in manual digit 1 [Term] id: OBA:0005189 @@ -149394,8 +248749,8 @@ synonym: "morphology of lymph node germinal center mantle zone" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010420 ! lymph node germinal center mantle zone -relationship: inheres_in UBERON:0010420 ! lymph node germinal center mantle zone +intersection_of: RO:0000052 UBERON:0010420 ! inheres in lymph node germinal center mantle zone +relationship: RO:0000052 UBERON:0010420 ! inheres in lymph node germinal center mantle zone [Term] id: OBA:0005190 @@ -149404,8 +248759,8 @@ def: "The morphology of a radiale." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of radiale" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003518 ! carpal bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001427 ! radiale -relationship: inheres_in UBERON:0001427 ! radiale +intersection_of: RO:0000052 UBERON:0001427 ! inheres in radiale +relationship: RO:0000052 UBERON:0001427 ! inheres in radiale [Term] id: OBA:0005191 @@ -149414,8 +248769,8 @@ def: "The morphology of a placenta metrial gland." [AUTO:patterns/patterns/entit synonym: "morphology of placenta metrial gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005808 ! female reproductive gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008855 ! placenta metrial gland -relationship: inheres_in UBERON:0008855 ! placenta metrial gland +intersection_of: RO:0000052 UBERON:0008855 ! inheres in placenta metrial gland +relationship: RO:0000052 UBERON:0008855 ! inheres in placenta metrial gland [Term] id: OBA:0005192 @@ -149425,8 +248780,8 @@ synonym: "amount of placenta metrial gland" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008855 ! placenta metrial gland -relationship: inheres_in UBERON:0008855 ! placenta metrial gland +intersection_of: RO:0000052 UBERON:0008855 ! inheres in placenta metrial gland +relationship: RO:0000052 UBERON:0008855 ! inheres in placenta metrial gland [Term] id: OBA:0005193 @@ -149436,8 +248791,8 @@ synonym: "morphology of fundus of stomach" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001160 ! fundus of stomach -relationship: inheres_in UBERON:0001160 ! fundus of stomach +intersection_of: RO:0000052 UBERON:0001160 ! inheres in fundus of stomach +relationship: RO:0000052 UBERON:0001160 ! inheres in fundus of stomach [Term] id: OBA:0005194 @@ -149447,8 +248802,8 @@ synonym: "morphology of stomach muscularis externa" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008856 ! stomach muscularis externa -relationship: inheres_in UBERON:0008856 ! stomach muscularis externa +intersection_of: RO:0000052 UBERON:0008856 ! inheres in stomach muscularis externa +relationship: RO:0000052 UBERON:0008856 ! inheres in stomach muscularis externa [Term] id: OBA:0005195 @@ -149458,8 +248813,8 @@ synonym: "morphology of stomach smooth muscle circular layer" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008857 ! stomach smooth muscle circular layer -relationship: inheres_in UBERON:0008857 ! stomach smooth muscle circular layer +intersection_of: RO:0000052 UBERON:0008857 ! inheres in stomach smooth muscle circular layer +relationship: RO:0000052 UBERON:0008857 ! inheres in stomach smooth muscle circular layer [Term] id: OBA:0005196 @@ -149469,8 +248824,8 @@ synonym: "morphology of wall of stomach" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001167 ! wall of stomach -relationship: inheres_in UBERON:0001167 ! wall of stomach +intersection_of: RO:0000052 UBERON:0001167 ! inheres in wall of stomach +relationship: RO:0000052 UBERON:0001167 ! inheres in wall of stomach [Term] id: OBA:0005197 @@ -149480,8 +248835,8 @@ synonym: "morphology of murine forestomach" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008827 ! murine forestomach -relationship: inheres_in UBERON:0008827 ! murine forestomach +intersection_of: RO:0000052 UBERON:0008827 ! inheres in murine forestomach +relationship: RO:0000052 UBERON:0008827 ! inheres in murine forestomach [Term] id: OBA:0005198 @@ -149491,8 +248846,8 @@ synonym: "morphology of pylorus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001166 ! pylorus -relationship: inheres_in UBERON:0001166 ! pylorus +intersection_of: RO:0000052 UBERON:0001166 ! inheres in pylorus +relationship: RO:0000052 UBERON:0001166 ! inheres in pylorus [Term] id: OBA:0005199 @@ -149502,7 +248857,7 @@ synonym: "size of fundus of stomach" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005193 ! fundus of stomach morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001160 ! fundus of stomach +intersection_of: RO:0000052 UBERON:0001160 ! inheres in fundus of stomach [Term] id: OBA:0005200 @@ -149511,8 +248866,8 @@ def: "The morphology of a mesentery of stomach." [AUTO:patterns/patterns/entity_ synonym: "morphology of mesentery of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001045 ! mesentery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003281 ! mesentery of stomach -relationship: inheres_in UBERON:0003281 ! mesentery of stomach +intersection_of: RO:0000052 UBERON:0003281 ! inheres in mesentery of stomach +relationship: RO:0000052 UBERON:0003281 ! inheres in mesentery of stomach [Term] id: OBA:0005201 @@ -149522,8 +248877,8 @@ synonym: "morphology of pyloric antrum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001165 ! pyloric antrum -relationship: inheres_in UBERON:0001165 ! pyloric antrum +intersection_of: RO:0000052 UBERON:0001165 ! inheres in pyloric antrum +relationship: RO:0000052 UBERON:0001165 ! inheres in pyloric antrum [Term] id: OBA:0005202 @@ -149533,8 +248888,8 @@ synonym: "morphology of pyloric canal" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008858 ! pyloric canal -relationship: inheres_in UBERON:0008858 ! pyloric canal +intersection_of: RO:0000052 UBERON:0008858 ! inheres in pyloric canal +relationship: RO:0000052 UBERON:0008858 ! inheres in pyloric canal [Term] id: OBA:0005203 @@ -149544,8 +248899,8 @@ synonym: "morphology of serosa of stomach" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001201 ! serosa of stomach -relationship: inheres_in UBERON:0001201 ! serosa of stomach +intersection_of: RO:0000052 UBERON:0001201 ! inheres in serosa of stomach +relationship: RO:0000052 UBERON:0001201 ! inheres in serosa of stomach [Term] id: OBA:0005204 @@ -149555,8 +248910,8 @@ synonym: "morphology of submucosa of stomach" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001200 ! submucosa of stomach -relationship: inheres_in UBERON:0001200 ! submucosa of stomach +intersection_of: RO:0000052 UBERON:0001200 ! inheres in submucosa of stomach +relationship: RO:0000052 UBERON:0001200 ! inheres in submucosa of stomach [Term] id: OBA:0005205 @@ -149566,8 +248921,8 @@ synonym: "morphology of cardiac gastric gland" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0003892 ! gastric gland morphology trait is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008859 ! cardiac gastric gland -relationship: inheres_in UBERON:0008859 ! cardiac gastric gland +intersection_of: RO:0000052 UBERON:0008859 ! inheres in cardiac gastric gland +relationship: RO:0000052 UBERON:0008859 ! inheres in cardiac gastric gland [Term] id: OBA:0005206 @@ -149577,8 +248932,8 @@ synonym: "morphology of intermediate gastric gland" EXACT [AUTO:patterns/pattern is_a: OBA:VT0003892 ! gastric gland morphology trait is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008860 ! intermediate gastric gland -relationship: inheres_in UBERON:0008860 ! intermediate gastric gland +intersection_of: RO:0000052 UBERON:0008860 ! inheres in intermediate gastric gland +relationship: RO:0000052 UBERON:0008860 ! inheres in intermediate gastric gland [Term] id: OBA:0005207 @@ -149588,8 +248943,8 @@ synonym: "morphology of pyloric gastric gland" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0003892 ! gastric gland morphology trait is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008861 ! pyloric gastric gland -relationship: inheres_in UBERON:0008861 ! pyloric gastric gland +intersection_of: RO:0000052 UBERON:0008861 ! inheres in pyloric gastric gland +relationship: RO:0000052 UBERON:0008861 ! inheres in pyloric gastric gland [Term] id: OBA:0005208 @@ -149599,8 +248954,8 @@ synonym: "morphology of cardia of stomach" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001162 ! cardia of stomach -relationship: inheres_in UBERON:0001162 ! cardia of stomach +intersection_of: RO:0000052 UBERON:0001162 ! inheres in cardia of stomach +relationship: RO:0000052 UBERON:0001162 ! inheres in cardia of stomach [Term] id: OBA:0005209 @@ -149610,7 +248965,7 @@ synonym: "size of mucosa of stomach" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005209 ! gastric mucosa morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001199 ! mucosa of stomach +intersection_of: RO:0000052 UBERON:0001199 ! inheres in mucosa of stomach [Term] id: OBA:0005210 @@ -149620,8 +248975,8 @@ synonym: "morphology of submucous nerve plexus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005304 ! submucous nerve plexus -relationship: inheres_in UBERON:0005304 ! submucous nerve plexus +intersection_of: RO:0000052 UBERON:0005304 ! inheres in submucous nerve plexus +relationship: RO:0000052 UBERON:0005304 ! inheres in submucous nerve plexus [Term] id: OBA:0005211 @@ -149631,8 +248986,8 @@ synonym: "morphology of myenteric nerve plexus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002439 ! myenteric nerve plexus -relationship: inheres_in UBERON:0002439 ! myenteric nerve plexus +intersection_of: RO:0000052 UBERON:0002439 ! inheres in myenteric nerve plexus +relationship: RO:0000052 UBERON:0002439 ! inheres in myenteric nerve plexus [Term] id: OBA:0005212 @@ -149641,8 +248996,8 @@ def: "The morphology of a intestinal enteroendocrine cell." [AUTO:patterns/patte synonym: "morphology of intestinal enteroendocrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001516 ! intestinal enteroendocrine cell -relationship: inheres_in CL:1001516 ! intestinal enteroendocrine cell +intersection_of: RO:0000052 CL:1001516 ! inheres in intestinal enteroendocrine cell +relationship: RO:0000052 CL:1001516 ! inheres in intestinal enteroendocrine cell [Term] id: OBA:0005213 @@ -149651,8 +249006,8 @@ def: "The morphology of a stomach enteroendocrine cell." [AUTO:patterns/patterns synonym: "morphology of stomach enteroendocrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001517 ! stomach enteroendocrine cell -relationship: inheres_in CL:1001517 ! stomach enteroendocrine cell +intersection_of: RO:0000052 CL:1001517 ! inheres in stomach enteroendocrine cell +relationship: RO:0000052 CL:1001517 ! inheres in stomach enteroendocrine cell [Term] id: OBA:0005214 @@ -149662,8 +249017,8 @@ synonym: "morphology of stomach smooth muscle inner oblique layer" EXACT [AUTO:p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008862 ! stomach smooth muscle inner oblique layer -relationship: inheres_in UBERON:0008862 ! stomach smooth muscle inner oblique layer +intersection_of: RO:0000052 UBERON:0008862 ! inheres in stomach smooth muscle inner oblique layer +relationship: RO:0000052 UBERON:0008862 ! inheres in stomach smooth muscle inner oblique layer [Term] id: OBA:0005215 @@ -149673,8 +249028,8 @@ synonym: "morphology of stomach smooth muscle outer longitudinal layer" EXACT [A is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008863 ! stomach smooth muscle outer longitudinal layer -relationship: inheres_in UBERON:0008863 ! stomach smooth muscle outer longitudinal layer +intersection_of: RO:0000052 UBERON:0008863 ! inheres in stomach smooth muscle outer longitudinal layer +relationship: RO:0000052 UBERON:0008863 ! inheres in stomach smooth muscle outer longitudinal layer [Term] id: OBA:0005216 @@ -149683,8 +249038,8 @@ def: "The morphology of a muscularis mucosae of stomach." [AUTO:patterns/pattern synonym: "morphology of muscularis mucosae of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001203 ! muscularis mucosae of stomach -relationship: inheres_in UBERON:0001203 ! muscularis mucosae of stomach +intersection_of: RO:0000052 UBERON:0001203 ! inheres in muscularis mucosae of stomach +relationship: RO:0000052 UBERON:0001203 ! inheres in muscularis mucosae of stomach [Term] id: OBA:0005217 @@ -149693,8 +249048,8 @@ def: "The position of a stomach." [AUTO:patterns/patterns/entity_attribute] synonym: "position of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000945 ! stomach -relationship: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach +relationship: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:0005218 @@ -149703,8 +249058,8 @@ def: "The morphology of a club cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of club cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000158 ! club cell -relationship: inheres_in CL:0000158 ! club cell +intersection_of: RO:0000052 CL:0000158 ! inheres in club cell +relationship: RO:0000052 CL:0000158 ! inheres in club cell [Term] id: OBA:0005219 @@ -149714,8 +249069,8 @@ synonym: "amount of type II pneumocyte" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002063 ! type II pneumocyte -relationship: inheres_in CL:0002063 ! type II pneumocyte +intersection_of: RO:0000052 CL:0002063 ! inheres in type II pneumocyte +relationship: RO:0000052 CL:0002063 ! inheres in type II pneumocyte [Term] id: OBA:0005220 @@ -149725,8 +249080,8 @@ synonym: "morphology of alveolar lamellar body" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097208 ! alveolar lamellar body -relationship: inheres_in GO:0097208 ! alveolar lamellar body +intersection_of: RO:0000052 GO:0097208 ! inheres in alveolar lamellar body +relationship: RO:0000052 GO:0097208 ! inheres in alveolar lamellar body [Term] id: OBA:0005221 @@ -149736,8 +249091,8 @@ synonym: "amount of type I pneumocyte" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002062 ! type I pneumocyte -relationship: inheres_in CL:0002062 ! type I pneumocyte +intersection_of: RO:0000052 CL:0002062 ! inheres in type I pneumocyte +relationship: RO:0000052 CL:0002062 ! inheres in type I pneumocyte [Term] id: OBA:0005222 @@ -149747,8 +249102,8 @@ synonym: "morphology of pleura" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000977 ! pleura -relationship: inheres_in UBERON:0000977 ! pleura +intersection_of: RO:0000052 UBERON:0000977 ! inheres in pleura +relationship: RO:0000052 UBERON:0000977 ! inheres in pleura [Term] id: OBA:0005223 @@ -149758,8 +249113,8 @@ synonym: "morphology of visceral pleura" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002401 ! visceral pleura -relationship: inheres_in UBERON:0002401 ! visceral pleura +intersection_of: RO:0000052 UBERON:0002401 ! inheres in visceral pleura +relationship: RO:0000052 UBERON:0002401 ! inheres in visceral pleura [Term] id: OBA:0005224 @@ -149769,8 +249124,8 @@ synonym: "morphology of parietal pleura" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002400 ! parietal pleura -relationship: inheres_in UBERON:0002400 ! parietal pleura +intersection_of: RO:0000052 UBERON:0002400 ! inheres in parietal pleura +relationship: RO:0000052 UBERON:0002400 ! inheres in parietal pleura [Term] id: OBA:0005225 @@ -149780,8 +249135,8 @@ synonym: "amount of right lung accessory lobe" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004890 ! right lung accessory lobe -relationship: inheres_in UBERON:0004890 ! right lung accessory lobe +intersection_of: RO:0000052 UBERON:0004890 ! inheres in right lung accessory lobe +relationship: RO:0000052 UBERON:0004890 ! inheres in right lung accessory lobe [Term] id: OBA:0005226 @@ -149791,8 +249146,8 @@ synonym: "morphology of lung saccule" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000116 ! lung saccule -relationship: inheres_in UBERON:0000116 ! lung saccule +intersection_of: RO:0000052 UBERON:0000116 ! inheres in lung saccule +relationship: RO:0000052 UBERON:0000116 ! inheres in lung saccule [Term] id: OBA:0005227 @@ -149802,8 +249157,8 @@ synonym: "amount of lung saccule" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000116 ! lung saccule -relationship: inheres_in UBERON:0000116 ! lung saccule +intersection_of: RO:0000052 UBERON:0000116 ! inheres in lung saccule +relationship: RO:0000052 UBERON:0000116 ! inheres in lung saccule [Term] id: OBA:0005228 @@ -149813,7 +249168,7 @@ synonym: "size of lung saccule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005226 ! lung saccule morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000116 ! lung saccule +intersection_of: RO:0000052 UBERON:0000116 ! inheres in lung saccule [Term] id: OBA:0005229 @@ -149822,8 +249177,8 @@ def: "The morphology of a bronchioalveolar stem cell." [AUTO:patterns/patterns/e synonym: "morphology of bronchioalveolar stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005306 ! respiratory basal cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002638 ! bronchioalveolar stem cell -relationship: inheres_in CL:0002638 ! bronchioalveolar stem cell +intersection_of: RO:0000052 CL:0002638 ! inheres in bronchioalveolar stem cell +relationship: RO:0000052 CL:0002638 ! inheres in bronchioalveolar stem cell [Term] id: OBA:0005230 @@ -149833,8 +249188,8 @@ synonym: "amount of bronchioalveolar stem cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005307 ! respiratory basal cell amount is_a: OBA:VT0005488 ! bronchial epithelial cell quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002638 ! bronchioalveolar stem cell -relationship: inheres_in CL:0002638 ! bronchioalveolar stem cell +intersection_of: RO:0000052 CL:0002638 ! inheres in bronchioalveolar stem cell +relationship: RO:0000052 CL:0002638 ! inheres in bronchioalveolar stem cell [Term] id: OBA:0005231 @@ -149844,8 +249199,8 @@ synonym: "morphology of CD4-positive, alpha-beta memory T cell" EXACT [AUTO:patt is_a: OBA:0003713 ! CD4-positive, alpha-beta T cell morphology is_a: OBA:VT0006385 ! memory T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000897 ! CD4-positive, alpha-beta memory T cell -relationship: inheres_in CL:0000897 ! CD4-positive, alpha-beta memory T cell +intersection_of: RO:0000052 CL:0000897 ! inheres in CD4-positive, alpha-beta memory T cell +relationship: RO:0000052 CL:0000897 ! inheres in CD4-positive, alpha-beta memory T cell [Term] id: OBA:0005232 @@ -149855,8 +249210,8 @@ synonym: "amount of CD4-positive, alpha-beta memory T cell" EXACT [AUTO:patterns is_a: OBA:0004284 ! memory T cell amount is_a: OBA:0004294 ! CD4-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000897 ! CD4-positive, alpha-beta memory T cell -relationship: inheres_in CL:0000897 ! CD4-positive, alpha-beta memory T cell +intersection_of: RO:0000052 CL:0000897 ! inheres in CD4-positive, alpha-beta memory T cell +relationship: RO:0000052 CL:0000897 ! inheres in CD4-positive, alpha-beta memory T cell [Term] id: OBA:0005233 @@ -149866,8 +249221,8 @@ synonym: "morphology of CD8-positive, alpha-beta memory T cell" EXACT [AUTO:patt is_a: OBA:0004117 ! CD8-positive, alpha-beta T cell morphology is_a: OBA:VT0006385 ! memory T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000909 ! CD8-positive, alpha-beta memory T cell -relationship: inheres_in CL:0000909 ! CD8-positive, alpha-beta memory T cell +intersection_of: RO:0000052 CL:0000909 ! inheres in CD8-positive, alpha-beta memory T cell +relationship: RO:0000052 CL:0000909 ! inheres in CD8-positive, alpha-beta memory T cell [Term] id: OBA:0005234 @@ -149877,8 +249232,8 @@ synonym: "amount of CD8-positive, alpha-beta memory T cell" EXACT [AUTO:patterns is_a: OBA:0004284 ! memory T cell amount is_a: OBA:0004295 ! CD8-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000909 ! CD8-positive, alpha-beta memory T cell -relationship: inheres_in CL:0000909 ! CD8-positive, alpha-beta memory T cell +intersection_of: RO:0000052 CL:0000909 ! inheres in CD8-positive, alpha-beta memory T cell +relationship: RO:0000052 CL:0000909 ! inheres in CD8-positive, alpha-beta memory T cell [Term] id: OBA:0005235 @@ -149887,8 +249242,8 @@ def: "The morphology of a central memory CD4-positive, alpha-beta T cell." [AUTO synonym: "morphology of central memory CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005231 ! CD4-positive, alpha-beta memory T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000904 ! central memory CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000904 ! central memory CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000904 ! inheres in central memory CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000904 ! inheres in central memory CD4-positive, alpha-beta T cell [Term] id: OBA:0005236 @@ -149897,8 +249252,8 @@ def: "The amount of a central memory CD4-positive, alpha-beta T cell." [AUTO:pat synonym: "amount of central memory CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005232 ! CD4-positive, alpha-beta memory T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000904 ! central memory CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000904 ! central memory CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000904 ! inheres in central memory CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000904 ! inheres in central memory CD4-positive, alpha-beta T cell [Term] id: OBA:0005237 @@ -149907,8 +249262,8 @@ def: "The morphology of a effector memory CD4-positive, alpha-beta T cell." [AUT synonym: "morphology of effector memory CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005231 ! CD4-positive, alpha-beta memory T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000905 ! effector memory CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000905 ! effector memory CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000905 ! inheres in effector memory CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000905 ! inheres in effector memory CD4-positive, alpha-beta T cell [Term] id: OBA:0005238 @@ -149917,8 +249272,8 @@ def: "The amount of a effector memory CD4-positive, alpha-beta T cell." [AUTO:pa synonym: "amount of effector memory CD4-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005232 ! CD4-positive, alpha-beta memory T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000905 ! effector memory CD4-positive, alpha-beta T cell -relationship: inheres_in CL:0000905 ! effector memory CD4-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000905 ! inheres in effector memory CD4-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000905 ! inheres in effector memory CD4-positive, alpha-beta T cell [Term] id: OBA:0005239 @@ -149927,8 +249282,8 @@ def: "The morphology of a central memory CD8-positive, alpha-beta T cell." [AUTO synonym: "morphology of central memory CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005233 ! CD8-positive, alpha-beta memory T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000907 ! central memory CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000907 ! central memory CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000907 ! inheres in central memory CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000907 ! inheres in central memory CD8-positive, alpha-beta T cell [Term] id: OBA:0005240 @@ -149937,8 +249292,8 @@ def: "The amount of a central memory CD8-positive, alpha-beta T cell." [AUTO:pat synonym: "amount of central memory CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005234 ! CD8-positive, alpha-beta memory T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000907 ! central memory CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000907 ! central memory CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000907 ! inheres in central memory CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000907 ! inheres in central memory CD8-positive, alpha-beta T cell [Term] id: OBA:0005241 @@ -149947,8 +249302,8 @@ def: "The morphology of a effector memory CD8-positive, alpha-beta T cell." [AUT synonym: "morphology of effector memory CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005233 ! CD8-positive, alpha-beta memory T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000913 ! effector memory CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000913 ! effector memory CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000913 ! inheres in effector memory CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000913 ! inheres in effector memory CD8-positive, alpha-beta T cell [Term] id: OBA:0005242 @@ -149957,8 +249312,8 @@ def: "The amount of a effector memory CD8-positive, alpha-beta T cell." [AUTO:pa synonym: "amount of effector memory CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005234 ! CD8-positive, alpha-beta memory T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000913 ! effector memory CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000913 ! effector memory CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000913 ! inheres in effector memory CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000913 ! inheres in effector memory CD8-positive, alpha-beta T cell [Term] id: OBA:0005243 @@ -149967,8 +249322,8 @@ def: "The morphology of a anterior commissure anterior part." [AUTO:patterns/pat synonym: "morphology of anterior commissure anterior part" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002199 ! brain commissure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003039 ! anterior commissure anterior part -relationship: inheres_in UBERON:0003039 ! anterior commissure anterior part +intersection_of: RO:0000052 UBERON:0003039 ! inheres in anterior commissure anterior part +relationship: RO:0000052 UBERON:0003039 ! inheres in anterior commissure anterior part [Term] id: OBA:0005244 @@ -149977,8 +249332,8 @@ def: "The morphology of a posterior part of anterior commissure." [AUTO:patterns synonym: "morphology of posterior part of anterior commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002199 ! brain commissure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003043 ! posterior part of anterior commissure -relationship: inheres_in UBERON:0003043 ! posterior part of anterior commissure +intersection_of: RO:0000052 UBERON:0003043 ! inheres in posterior part of anterior commissure +relationship: RO:0000052 UBERON:0003043 ! inheres in posterior part of anterior commissure [Term] id: OBA:0005245 @@ -149988,8 +249343,8 @@ synonym: "amount of respiratory goblet cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002370 ! respiratory goblet cell -relationship: inheres_in CL:0002370 ! respiratory goblet cell +intersection_of: RO:0000052 CL:0002370 ! inheres in respiratory goblet cell +relationship: RO:0000052 CL:0002370 ! inheres in respiratory goblet cell [Term] id: OBA:0005246 @@ -149999,8 +249354,8 @@ synonym: "morphology of enamel knot" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008866 ! enamel knot -relationship: inheres_in UBERON:0008866 ! enamel knot +intersection_of: RO:0000052 UBERON:0008866 ! inheres in enamel knot +relationship: RO:0000052 UBERON:0008866 ! inheres in enamel knot [Term] id: OBA:0005247 @@ -150010,8 +249365,8 @@ synonym: "amount of trabecular network of bone" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008867 ! trabecular network of bone -relationship: inheres_in UBERON:0008867 ! trabecular network of bone +intersection_of: RO:0000052 UBERON:0008867 ! inheres in trabecular network of bone +relationship: RO:0000052 UBERON:0008867 ! inheres in trabecular network of bone [Term] id: OBA:0005248 @@ -150021,8 +249376,8 @@ synonym: "mass of trabecular bone tissue" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002483 ! trabecular bone tissue -relationship: inheres_in UBERON:0002483 ! trabecular bone tissue +intersection_of: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue +relationship: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue [Term] id: OBA:0005249 @@ -150032,8 +249387,8 @@ synonym: "amount of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003126 ! trachea -relationship: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea +relationship: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0005250 @@ -150043,8 +249398,8 @@ synonym: "amount of minor salivary gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001830 ! minor salivary gland -relationship: inheres_in UBERON:0001830 ! minor salivary gland +intersection_of: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland +relationship: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland [Term] id: OBA:0005251 @@ -150054,8 +249409,8 @@ synonym: "color saturation of lung" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0002048 ! lung -relationship: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung +relationship: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:0005252 @@ -150065,8 +249420,8 @@ synonym: "amount of alveolar lamellar body" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0097208 ! alveolar lamellar body -relationship: inheres_in GO:0097208 ! alveolar lamellar body +intersection_of: RO:0000052 GO:0097208 ! inheres in alveolar lamellar body +relationship: RO:0000052 GO:0097208 ! inheres in alveolar lamellar body [Term] id: OBA:0005253 @@ -150075,8 +249430,8 @@ def: "The morphology of a posterior commissure." [AUTO:patterns/patterns/entity_ synonym: "morphology of posterior commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002199 ! brain commissure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000936 ! posterior commissure -relationship: inheres_in UBERON:0000936 ! posterior commissure +intersection_of: RO:0000052 UBERON:0000936 ! inheres in posterior commissure +relationship: RO:0000052 UBERON:0000936 ! inheres in posterior commissure [Term] id: OBA:0005254 @@ -150086,8 +249441,8 @@ synonym: "morphology of epithelium of bronchiole" EXACT [AUTO:patterns/patterns/ is_a: OBA:0004249 ! lung epithelium morphology is_a: OBA:0005280 ! epithelium of bronchus morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002051 ! epithelium of bronchiole -relationship: inheres_in UBERON:0002051 ! epithelium of bronchiole +intersection_of: RO:0000052 UBERON:0002051 ! inheres in epithelium of bronchiole +relationship: RO:0000052 UBERON:0002051 ! inheres in epithelium of bronchiole [Term] id: OBA:0005255 @@ -150096,8 +249451,8 @@ def: "The morphology of a pulmonary alveolus epithelium." [AUTO:patterns/pattern synonym: "morphology of pulmonary alveolus epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004249 ! lung epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004821 ! pulmonary alveolus epithelium -relationship: inheres_in UBERON:0004821 ! pulmonary alveolus epithelium +intersection_of: RO:0000052 UBERON:0004821 ! inheres in pulmonary alveolus epithelium +relationship: RO:0000052 UBERON:0004821 ! inheres in pulmonary alveolus epithelium [Term] id: OBA:0005256 @@ -150107,8 +249462,8 @@ synonym: "morphology of alveolar system" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006524 ! alveolar system -relationship: inheres_in UBERON:0006524 ! alveolar system +intersection_of: RO:0000052 UBERON:0006524 ! inheres in alveolar system +relationship: RO:0000052 UBERON:0006524 ! inheres in alveolar system [Term] id: OBA:0005257 @@ -150118,8 +249473,8 @@ synonym: "morphology of interalveolar septum" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004893 ! interalveolar septum -relationship: inheres_in UBERON:0004893 ! interalveolar septum +intersection_of: RO:0000052 UBERON:0004893 ! inheres in interalveolar septum +relationship: RO:0000052 UBERON:0004893 ! inheres in interalveolar septum [Term] id: OBA:0005258 @@ -150129,8 +249484,8 @@ synonym: "morphology of pulmonary alveolar parenchyma" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008870 ! pulmonary alveolar parenchyma -relationship: inheres_in UBERON:0008870 ! pulmonary alveolar parenchyma +intersection_of: RO:0000052 UBERON:0008870 ! inheres in pulmonary alveolar parenchyma +relationship: RO:0000052 UBERON:0008870 ! inheres in pulmonary alveolar parenchyma [Term] id: OBA:0005259 @@ -150140,8 +249495,8 @@ synonym: "morphology of alveolar sac" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0004249 ! lung epithelium morphology is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002169 ! alveolar sac -relationship: inheres_in UBERON:0002169 ! alveolar sac +intersection_of: RO:0000052 UBERON:0002169 ! inheres in alveolar sac +relationship: RO:0000052 UBERON:0002169 ! inheres in alveolar sac [Term] id: OBA:0005260 @@ -150151,8 +249506,8 @@ synonym: "morphology of alveolar wall" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004894 ! alveolar wall -relationship: inheres_in UBERON:0004894 ! alveolar wall +intersection_of: RO:0000052 UBERON:0004894 ! inheres in alveolar wall +relationship: RO:0000052 UBERON:0004894 ! inheres in alveolar wall [Term] id: OBA:0005261 @@ -150162,8 +249517,8 @@ synonym: "morphology of alveolar pore" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008873 ! alveolar pore -relationship: inheres_in UBERON:0008873 ! alveolar pore +intersection_of: RO:0000052 UBERON:0008873 ! inheres in alveolar pore +relationship: RO:0000052 UBERON:0008873 ! inheres in alveolar pore [Term] id: OBA:0005262 @@ -150173,8 +249528,8 @@ synonym: "amount of alveolar pore" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008873 ! alveolar pore -relationship: inheres_in UBERON:0008873 ! alveolar pore +intersection_of: RO:0000052 UBERON:0008873 ! inheres in alveolar pore +relationship: RO:0000052 UBERON:0008873 ! inheres in alveolar pore [Term] id: OBA:0005263 @@ -150184,8 +249539,8 @@ synonym: "morphology of lung bud" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000118 ! lung bud -relationship: inheres_in UBERON:0000118 ! lung bud +intersection_of: RO:0000052 UBERON:0000118 ! inheres in lung bud +relationship: RO:0000052 UBERON:0000118 ! inheres in lung bud [Term] id: OBA:0005264 @@ -150195,8 +249550,8 @@ synonym: "amount of lung bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000118 ! lung bud -relationship: inheres_in UBERON:0000118 ! lung bud +intersection_of: RO:0000052 UBERON:0000118 ! inheres in lung bud +relationship: RO:0000052 UBERON:0000118 ! inheres in lung bud [Term] id: OBA:0005265 @@ -150206,7 +249561,7 @@ synonym: "size of epithelium of bronchiole" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0005254 ! epithelium of bronchiole morphology is_a: OBA:0005282 ! lung epithelium size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002051 ! epithelium of bronchiole +intersection_of: RO:0000052 UBERON:0002051 ! inheres in epithelium of bronchiole [Term] id: OBA:0005266 @@ -150216,8 +249571,8 @@ synonym: "morphology of pulmonary acinus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008874 ! pulmonary acinus -relationship: inheres_in UBERON:0008874 ! pulmonary acinus +intersection_of: RO:0000052 UBERON:0008874 ! inheres in pulmonary acinus +relationship: RO:0000052 UBERON:0008874 ! inheres in pulmonary acinus [Term] id: OBA:0005267 @@ -150227,7 +249582,7 @@ synonym: "position of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position is_a: OBA:1000635 ! liver quality intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:0005268 @@ -150236,8 +249591,8 @@ def: "The morphology of a neuroendocrine cell." [AUTO:patterns/patterns/entity_a synonym: "morphology of neuroendocrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000165 ! neuroendocrine cell -relationship: inheres_in CL:0000165 ! neuroendocrine cell +intersection_of: RO:0000052 CL:0000165 ! inheres in neuroendocrine cell +relationship: RO:0000052 CL:0000165 ! inheres in neuroendocrine cell [Term] id: OBA:0005269 @@ -150246,8 +249601,8 @@ def: "The morphology of a Feyrter cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of Feyrter cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005268 ! neuroendocrine cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002066 ! Feyrter cell -relationship: inheres_in CL:0002066 ! Feyrter cell +intersection_of: RO:0000052 CL:0002066 ! inheres in Feyrter cell +relationship: RO:0000052 CL:0002066 ! inheres in Feyrter cell [Term] id: OBA:0005270 @@ -150257,8 +249612,8 @@ synonym: "amount of Feyrter cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002066 ! Feyrter cell -relationship: inheres_in CL:0002066 ! Feyrter cell +intersection_of: RO:0000052 CL:0002066 ! inheres in Feyrter cell +relationship: RO:0000052 CL:0002066 ! inheres in Feyrter cell [Term] id: OBA:0005271 @@ -150268,8 +249623,8 @@ synonym: "morphology of pulmonary neuroendocrine body" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010002 ! pulmonary neuroendocrine body -relationship: inheres_in UBERON:0010002 ! pulmonary neuroendocrine body +intersection_of: RO:0000052 UBERON:0010002 ! inheres in pulmonary neuroendocrine body +relationship: RO:0000052 UBERON:0010002 ! inheres in pulmonary neuroendocrine body [Term] id: OBA:0005272 @@ -150279,8 +249634,8 @@ synonym: "amount of pulmonary neuroendocrine body" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0010002 ! pulmonary neuroendocrine body -relationship: inheres_in UBERON:0010002 ! pulmonary neuroendocrine body +intersection_of: RO:0000052 UBERON:0010002 ! inheres in pulmonary neuroendocrine body +relationship: RO:0000052 UBERON:0010002 ! inheres in pulmonary neuroendocrine body [Term] id: OBA:0005273 @@ -150290,7 +249645,7 @@ synonym: "composition of alveolus of lung" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002270 ! respiratory alveoli morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002299 ! alveolus of lung +intersection_of: RO:0000052 UBERON:0002299 ! inheres in alveolus of lung [Term] id: OBA:0005274 @@ -150299,8 +249654,8 @@ def: "The morphology of a osteoid." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of osteoid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008883 ! osteoid -relationship: inheres_in UBERON:0008883 ! osteoid +intersection_of: RO:0000052 UBERON:0008883 ! inheres in osteoid +relationship: RO:0000052 UBERON:0008883 ! inheres in osteoid [Term] id: OBA:0005275 @@ -150310,7 +249665,7 @@ synonym: "size of osteoid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005274 ! osteoid morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008883 ! osteoid +intersection_of: RO:0000052 UBERON:0008883 ! inheres in osteoid [Term] id: OBA:0005276 @@ -150320,8 +249675,8 @@ synonym: "morphology of mandibular prominence" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005867 ! mandibular prominence -relationship: inheres_in UBERON:0005867 ! mandibular prominence +intersection_of: RO:0000052 UBERON:0005867 ! inheres in mandibular prominence +relationship: RO:0000052 UBERON:0005867 ! inheres in mandibular prominence [Term] id: OBA:0005277 @@ -150331,8 +249686,8 @@ synonym: "morphology of maxillary prominence" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005868 ! maxillary prominence -relationship: inheres_in UBERON:0005868 ! maxillary prominence +intersection_of: RO:0000052 UBERON:0005868 ! inheres in maxillary prominence +relationship: RO:0000052 UBERON:0005868 ! inheres in maxillary prominence [Term] id: OBA:0005278 @@ -150342,8 +249697,8 @@ synonym: "morphology of foramen magnum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003687 ! foramen magnum -relationship: inheres_in UBERON:0003687 ! foramen magnum +intersection_of: RO:0000052 UBERON:0003687 ! inheres in foramen magnum +relationship: RO:0000052 UBERON:0003687 ! inheres in foramen magnum [Term] id: OBA:0005279 @@ -150352,8 +249707,8 @@ def: "The morphology of a respiratory tract epithelium." [AUTO:patterns/patterns synonym: "morphology of respiratory tract epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003297 ! respiratory system epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004802 ! respiratory tract epithelium -relationship: inheres_in UBERON:0004802 ! respiratory tract epithelium +intersection_of: RO:0000052 UBERON:0004802 ! inheres in respiratory tract epithelium +relationship: RO:0000052 UBERON:0004802 ! inheres in respiratory tract epithelium [Term] id: OBA:0005280 @@ -150362,8 +249717,8 @@ def: "The morphology of a epithelium of bronchus." [AUTO:patterns/patterns/entit synonym: "morphology of epithelium of bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002031 ! epithelium of bronchus -relationship: inheres_in UBERON:0002031 ! epithelium of bronchus +intersection_of: RO:0000052 UBERON:0002031 ! inheres in epithelium of bronchus +relationship: RO:0000052 UBERON:0002031 ! inheres in epithelium of bronchus [Term] id: OBA:0005281 @@ -150373,7 +249728,7 @@ synonym: "size of respiratory tract epithelium" EXACT [AUTO:patterns/patterns/en is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004802 ! respiratory tract epithelium +intersection_of: RO:0000052 UBERON:0004802 ! inheres in respiratory tract epithelium [Term] id: OBA:0005282 @@ -150383,7 +249738,7 @@ synonym: "size of lung epithelium" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0004249 ! lung epithelium morphology is_a: OBA:0005281 ! respiratory tract epithelium size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000115 ! lung epithelium +intersection_of: RO:0000052 UBERON:0000115 ! inheres in lung epithelium [Term] id: OBA:0005283 @@ -150392,8 +249747,8 @@ def: "The amount of a club cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of club cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005488 ! bronchial epithelial cell quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000158 ! club cell -relationship: inheres_in CL:0000158 ! club cell +intersection_of: RO:0000052 CL:0000158 ! inheres in club cell +relationship: RO:0000052 CL:0000158 ! inheres in club cell [Term] id: OBA:0005284 @@ -150403,8 +249758,8 @@ synonym: "mass of compact bone tissue" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001439 ! compact bone tissue -relationship: inheres_in UBERON:0001439 ! compact bone tissue +intersection_of: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue +relationship: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue [Term] id: OBA:0005285 @@ -150414,8 +249769,8 @@ synonym: "amount of compact bone tissue" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001439 ! compact bone tissue -relationship: inheres_in UBERON:0001439 ! compact bone tissue +intersection_of: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue +relationship: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue [Term] id: OBA:0005286 @@ -150425,7 +249780,7 @@ synonym: "morphology of periosteum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000192 ! periosteum quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002515 ! periosteum +intersection_of: RO:0000052 UBERON:0002515 ! inheres in periosteum [Term] id: OBA:0005287 @@ -150435,7 +249790,7 @@ synonym: "amount of periosteum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000192 ! periosteum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002515 ! periosteum +intersection_of: RO:0000052 UBERON:0002515 ! inheres in periosteum [Term] id: OBA:0005288 @@ -150445,7 +249800,7 @@ synonym: "size of periosteum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005286 ! periosteum morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002515 ! periosteum +intersection_of: RO:0000052 UBERON:0002515 ! inheres in periosteum [Term] id: OBA:0005289 @@ -150455,8 +249810,8 @@ synonym: "morphology of lobe of lung" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000101 ! lobe of lung -relationship: inheres_in UBERON:0000101 ! lobe of lung +intersection_of: RO:0000052 UBERON:0000101 ! inheres in lobe of lung +relationship: RO:0000052 UBERON:0000101 ! inheres in lobe of lung [Term] id: OBA:0005290 @@ -150466,7 +249821,7 @@ synonym: "size of lobe of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005289 ! lobe of lung morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000101 ! lobe of lung +intersection_of: RO:0000052 UBERON:0000101 ! inheres in lobe of lung [Term] id: OBA:0005291 @@ -150476,8 +249831,8 @@ synonym: "amount of ureteric bud" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000084 ! ureteric bud -relationship: inheres_in UBERON:0000084 ! ureteric bud +intersection_of: RO:0000052 UBERON:0000084 ! inheres in ureteric bud +relationship: RO:0000052 UBERON:0000084 ! inheres in ureteric bud [Term] id: OBA:0005292 @@ -150488,7 +249843,7 @@ is_a: OBA:0000172 ! tube size is_a: OBA:0004106 ! kidney epithelium size is_a: OBA:VT0006032 ! ureteric bud morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000084 ! ureteric bud +intersection_of: RO:0000052 UBERON:0000084 ! inheres in ureteric bud [Term] id: OBA:0005293 @@ -150498,8 +249853,8 @@ synonym: "displaced of ureteric bud" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000084 ! ureteric bud -relationship: inheres_in UBERON:0000084 ! ureteric bud +intersection_of: RO:0000052 UBERON:0000084 ! inheres in ureteric bud +relationship: RO:0000052 UBERON:0000084 ! inheres in ureteric bud [Term] id: OBA:0005294 @@ -150509,8 +249864,8 @@ synonym: "morphology of metanephric mesenchyme" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0005295 ! kidney mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003220 ! metanephric mesenchyme -relationship: inheres_in UBERON:0003220 ! metanephric mesenchyme +intersection_of: RO:0000052 UBERON:0003220 ! inheres in metanephric mesenchyme +relationship: RO:0000052 UBERON:0003220 ! inheres in metanephric mesenchyme [Term] id: OBA:0005295 @@ -150519,8 +249874,8 @@ def: "The morphology of a kidney mesenchyme." [AUTO:patterns/patterns/entity_att synonym: "morphology of kidney mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003918 ! kidney mesenchyme -relationship: inheres_in UBERON:0003918 ! kidney mesenchyme +intersection_of: RO:0000052 UBERON:0003918 ! inheres in kidney mesenchyme +relationship: RO:0000052 UBERON:0003918 ! inheres in kidney mesenchyme [Term] id: OBA:0005296 @@ -150529,8 +249884,8 @@ def: "The morphology of a mesonephric mesenchyme." [AUTO:patterns/patterns/entit synonym: "morphology of mesonephric mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005323 ! mesonephric mesenchyme -relationship: inheres_in UBERON:0005323 ! mesonephric mesenchyme +intersection_of: RO:0000052 UBERON:0005323 ! inheres in mesonephric mesenchyme +relationship: RO:0000052 UBERON:0005323 ! inheres in mesonephric mesenchyme [Term] id: OBA:0005297 @@ -150539,8 +249894,8 @@ def: "The morphology of a cartilage of bronchus." [AUTO:patterns/patterns/entity synonym: "morphology of cartilage of bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001956 ! cartilage of bronchus -relationship: inheres_in UBERON:0001956 ! cartilage of bronchus +intersection_of: RO:0000052 UBERON:0001956 ! inheres in cartilage of bronchus +relationship: RO:0000052 UBERON:0001956 ! inheres in cartilage of bronchus [Term] id: OBA:0005298 @@ -150550,7 +249905,7 @@ synonym: "size of aorta wall" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004882 ! aorta wall morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004663 ! aorta wall +intersection_of: RO:0000052 UBERON:0004663 ! inheres in aorta wall [Term] id: OBA:0005299 @@ -150559,8 +249914,8 @@ def: "The morphology of a stem cell of epidermis." [AUTO:patterns/patterns/entit synonym: "morphology of stem cell of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000428 ! stem cell of epidermis -relationship: inheres_in CL:1000428 ! stem cell of epidermis +intersection_of: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis +relationship: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis [Term] id: OBA:0005300 @@ -150569,8 +249924,8 @@ def: "The functionality of a stem cell of epidermis." [AUTO:patterns/patterns/en synonym: "functionality of stem cell of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:1000428 ! stem cell of epidermis -relationship: inheres_in CL:1000428 ! stem cell of epidermis +intersection_of: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis +relationship: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis [Term] id: OBA:0005301 @@ -150580,8 +249935,8 @@ synonym: "occurrence of lung lobe morphogenesis" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0060463 ! lung lobe morphogenesis -relationship: inheres_in GO:0060463 ! lung lobe morphogenesis +intersection_of: RO:0000052 GO:0060463 ! inheres in lung lobe morphogenesis +relationship: RO:0000052 GO:0060463 ! inheres in lung lobe morphogenesis [Term] id: OBA:0005302 @@ -150591,8 +249946,8 @@ synonym: "elasticity of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001031 ! elasticity intersection_of: PATO:0001031 ! elasticity -intersection_of: inheres_in UBERON:0002048 ! lung -relationship: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung +relationship: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:0005303 @@ -150602,8 +249957,8 @@ synonym: "morphology of kinocilium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005768 ! non-motile cilium morphology is_a: OBA:VT0015108 ! neurite morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0060091 ! kinocilium -relationship: inheres_in GO:0060091 ! kinocilium +intersection_of: RO:0000052 GO:0060091 ! inheres in kinocilium +relationship: RO:0000052 GO:0060091 ! inheres in kinocilium [Term] id: OBA:0005304 @@ -150613,8 +249968,8 @@ synonym: "rate of macrophage cytokine production" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0010934 ! macrophage cytokine production -relationship: inheres_in GO:0010934 ! macrophage cytokine production +intersection_of: RO:0000052 GO:0010934 ! inheres in macrophage cytokine production +relationship: RO:0000052 GO:0010934 ! inheres in macrophage cytokine production [Term] id: OBA:0005305 @@ -150623,8 +249978,8 @@ def: "The rate of a macrophage apoptotic process." [AUTO:patterns/patterns/entit synonym: "rate of macrophage apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004174 ! apoptotic process rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0071888 ! macrophage apoptotic process -relationship: inheres_in GO:0071888 ! macrophage apoptotic process +intersection_of: RO:0000052 GO:0071888 ! inheres in macrophage apoptotic process +relationship: RO:0000052 GO:0071888 ! inheres in macrophage apoptotic process [Term] id: OBA:0005306 @@ -150633,8 +249988,8 @@ def: "The morphology of a respiratory basal cell." [AUTO:patterns/patterns/entit synonym: "morphology of respiratory basal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002633 ! respiratory basal cell -relationship: inheres_in CL:0002633 ! respiratory basal cell +intersection_of: RO:0000052 CL:0002633 ! inheres in respiratory basal cell +relationship: RO:0000052 CL:0002633 ! inheres in respiratory basal cell [Term] id: OBA:0005307 @@ -150644,8 +249999,8 @@ synonym: "amount of respiratory basal cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002633 ! respiratory basal cell -relationship: inheres_in CL:0002633 ! respiratory basal cell +intersection_of: RO:0000052 CL:0002633 ! inheres in respiratory basal cell +relationship: RO:0000052 CL:0002633 ! inheres in respiratory basal cell [Term] id: OBA:0005308 @@ -150655,8 +250010,8 @@ synonym: "amount of Reichert's membrane" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004369 ! Reichert's membrane -relationship: inheres_in UBERON:0004369 ! Reichert's membrane +intersection_of: RO:0000052 UBERON:0004369 ! inheres in Reichert's membrane +relationship: RO:0000052 UBERON:0004369 ! inheres in Reichert's membrane [Term] id: OBA:0005309 @@ -150665,8 +250020,8 @@ def: "The amount of a primordial ovarian follicle." [AUTO:patterns/patterns/enti synonym: "amount of primordial ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004516 ! ovarian follicle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003981 ! primordial ovarian follicle -relationship: inheres_in UBERON:0003981 ! primordial ovarian follicle +intersection_of: RO:0000052 UBERON:0003981 ! inheres in primordial ovarian follicle +relationship: RO:0000052 UBERON:0003981 ! inheres in primordial ovarian follicle [Term] id: OBA:0005310 @@ -150675,8 +250030,8 @@ def: "The amount of a primary ovarian follicle." [AUTO:patterns/patterns/entity_ synonym: "amount of primary ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004516 ! ovarian follicle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000035 ! primary ovarian follicle -relationship: inheres_in UBERON:0000035 ! primary ovarian follicle +intersection_of: RO:0000052 UBERON:0000035 ! inheres in primary ovarian follicle +relationship: RO:0000052 UBERON:0000035 ! inheres in primary ovarian follicle [Term] id: OBA:0005311 @@ -150685,8 +250040,8 @@ def: "The amount of a tertiary ovarian follicle." [AUTO:patterns/patterns/entity synonym: "amount of tertiary ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004516 ! ovarian follicle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000037 ! tertiary ovarian follicle -relationship: inheres_in UBERON:0000037 ! tertiary ovarian follicle +intersection_of: RO:0000052 UBERON:0000037 ! inheres in tertiary ovarian follicle +relationship: RO:0000052 UBERON:0000037 ! inheres in tertiary ovarian follicle [Term] id: OBA:0005312 @@ -150695,8 +250050,8 @@ def: "The amount of a secondary ovarian follicle." [AUTO:patterns/patterns/entit synonym: "amount of secondary ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004516 ! ovarian follicle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000036 ! secondary ovarian follicle -relationship: inheres_in UBERON:0000036 ! secondary ovarian follicle +intersection_of: RO:0000052 UBERON:0000036 ! inheres in secondary ovarian follicle +relationship: RO:0000052 UBERON:0000036 ! inheres in secondary ovarian follicle [Term] id: OBA:0005313 @@ -150705,8 +250060,8 @@ def: "The functionality of a lung endothelial cell." [AUTO:patterns/patterns/ent synonym: "functionality of lung endothelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:1001567 ! lung endothelial cell -relationship: inheres_in CL:1001567 ! lung endothelial cell +intersection_of: RO:0000052 CL:1001567 ! inheres in lung endothelial cell +relationship: RO:0000052 CL:1001567 ! inheres in lung endothelial cell [Term] id: OBA:0005314 @@ -150716,8 +250071,8 @@ synonym: "size of lung mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004883 ! lung mesenchyme -relationship: inheres_in UBERON:0004883 ! lung mesenchyme +intersection_of: RO:0000052 UBERON:0004883 ! inheres in lung mesenchyme +relationship: RO:0000052 UBERON:0004883 ! inheres in lung mesenchyme [Term] id: OBA:0005315 @@ -150727,8 +250082,8 @@ synonym: "amount of lung mesenchyme" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004883 ! lung mesenchyme -relationship: inheres_in UBERON:0004883 ! lung mesenchyme +intersection_of: RO:0000052 UBERON:0004883 ! inheres in lung mesenchyme +relationship: RO:0000052 UBERON:0004883 ! inheres in lung mesenchyme [Term] id: OBA:0005316 @@ -150737,8 +250092,8 @@ def: "The rate of a mesenchymal cell proliferation involved in lung development. synonym: "rate of mesenchymal cell proliferation involved in lung development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060916 ! mesenchymal cell proliferation involved in lung development -relationship: inheres_in GO:0060916 ! mesenchymal cell proliferation involved in lung development +intersection_of: RO:0000052 GO:0060916 ! inheres in mesenchymal cell proliferation involved in lung development +relationship: RO:0000052 GO:0060916 ! inheres in mesenchymal cell proliferation involved in lung development [Term] id: OBA:0005317 @@ -150747,8 +250102,8 @@ def: "The morphology of a hippocampus stratum lacunosum." [AUTO:patterns/pattern synonym: "morphology of hippocampus stratum lacunosum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000813 ! hippocampus layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005370 ! hippocampus stratum lacunosum -relationship: inheres_in UBERON:0005370 ! hippocampus stratum lacunosum +intersection_of: RO:0000052 UBERON:0005370 ! inheres in hippocampus stratum lacunosum +relationship: RO:0000052 UBERON:0005370 ! inheres in hippocampus stratum lacunosum [Term] id: OBA:0005318 @@ -150757,8 +250112,8 @@ def: "The morphology of a hippocampus stratum oriens." [AUTO:patterns/patterns/e synonym: "morphology of hippocampus stratum oriens" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000813 ! hippocampus layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005371 ! hippocampus stratum oriens -relationship: inheres_in UBERON:0005371 ! hippocampus stratum oriens +intersection_of: RO:0000052 UBERON:0005371 ! inheres in hippocampus stratum oriens +relationship: RO:0000052 UBERON:0005371 ! inheres in hippocampus stratum oriens [Term] id: OBA:0005319 @@ -150767,8 +250122,8 @@ def: "The morphology of a hippocampus stratum radiatum." [AUTO:patterns/patterns synonym: "morphology of hippocampus stratum radiatum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000813 ! hippocampus layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005372 ! hippocampus stratum radiatum -relationship: inheres_in UBERON:0005372 ! hippocampus stratum radiatum +intersection_of: RO:0000052 UBERON:0005372 ! inheres in hippocampus stratum radiatum +relationship: RO:0000052 UBERON:0005372 ! inheres in hippocampus stratum radiatum [Term] id: OBA:0005320 @@ -150778,7 +250133,7 @@ synonym: "size of hippocampus molecular layer" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0004353 ! hippocampus molecular layer morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005368 ! hippocampus molecular layer +intersection_of: RO:0000052 UBERON:0005368 ! inheres in hippocampus molecular layer [Term] id: OBA:0005321 @@ -150788,7 +250143,7 @@ synonym: "size of hippocampus stratum oriens" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0005318 ! hippocampus stratum oriens morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005371 ! hippocampus stratum oriens +intersection_of: RO:0000052 UBERON:0005371 ! inheres in hippocampus stratum oriens [Term] id: OBA:0005322 @@ -150798,7 +250153,7 @@ synonym: "size of hippocampus stratum radiatum" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005319 ! hippocampus stratum radiatum morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005372 ! hippocampus stratum radiatum +intersection_of: RO:0000052 UBERON:0005372 ! inheres in hippocampus stratum radiatum [Term] id: OBA:0005323 @@ -150808,8 +250163,8 @@ synonym: "amount of hippocampus stratum oriens" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005371 ! hippocampus stratum oriens -relationship: inheres_in UBERON:0005371 ! hippocampus stratum oriens +intersection_of: RO:0000052 UBERON:0005371 ! inheres in hippocampus stratum oriens +relationship: RO:0000052 UBERON:0005371 ! inheres in hippocampus stratum oriens [Term] id: OBA:0005324 @@ -150819,7 +250174,7 @@ synonym: "morphology of subcutaneous adipose tissue" EXACT [AUTO:patterns/patter is_a: OBA:1000023 ! subcutaneous adipose tissue quality is_a: OBA:VT0000003 ! adipose morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue [Term] id: OBA:0005325 @@ -150828,8 +250183,8 @@ def: "The morphology of a hypodermis skeletal muscle layer." [AUTO:patterns/patt synonym: "morphology of hypodermis skeletal muscle layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008876 ! hypodermis skeletal muscle layer -relationship: inheres_in UBERON:0008876 ! hypodermis skeletal muscle layer +intersection_of: RO:0000052 UBERON:0008876 ! inheres in hypodermis skeletal muscle layer +relationship: RO:0000052 UBERON:0008876 ! inheres in hypodermis skeletal muscle layer [Term] id: OBA:0005326 @@ -150839,8 +250194,8 @@ synonym: "amount of hypodermis skeletal muscle layer" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008876 ! hypodermis skeletal muscle layer -relationship: inheres_in UBERON:0008876 ! hypodermis skeletal muscle layer +intersection_of: RO:0000052 UBERON:0008876 ! inheres in hypodermis skeletal muscle layer +relationship: RO:0000052 UBERON:0008876 ! inheres in hypodermis skeletal muscle layer [Term] id: OBA:0005327 @@ -150850,8 +250205,8 @@ synonym: "morphology of epidermal-dermal junction" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008877 ! epidermal-dermal junction -relationship: inheres_in UBERON:0008877 ! epidermal-dermal junction +intersection_of: RO:0000052 UBERON:0008877 ! inheres in epidermal-dermal junction +relationship: RO:0000052 UBERON:0008877 ! inheres in epidermal-dermal junction [Term] id: OBA:0005329 @@ -150861,8 +250216,8 @@ synonym: "amount of root of molar tooth" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000486 ! tooth root quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008854 ! root of molar tooth -relationship: inheres_in UBERON:0008854 ! root of molar tooth +intersection_of: RO:0000052 UBERON:0008854 ! inheres in root of molar tooth +relationship: RO:0000052 UBERON:0008854 ! inheres in root of molar tooth [Term] id: OBA:0005330 @@ -150872,8 +250227,8 @@ synonym: "morphology of otic pit" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006273 ! otic pit -relationship: inheres_in UBERON:0006273 ! otic pit +intersection_of: RO:0000052 UBERON:0006273 ! inheres in otic pit +relationship: RO:0000052 UBERON:0006273 ! inheres in otic pit [Term] id: OBA:0005331 @@ -150883,8 +250238,8 @@ synonym: "morphology of otic placode" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003069 ! otic placode -relationship: inheres_in UBERON:0003069 ! otic placode +intersection_of: RO:0000052 UBERON:0003069 ! inheres in otic placode +relationship: RO:0000052 UBERON:0003069 ! inheres in otic placode [Term] id: OBA:0005332 @@ -150894,7 +250249,7 @@ synonym: "curvature of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002829 ! vertebra shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:0005333 @@ -150904,8 +250259,8 @@ synonym: "amount of hematopoietic cell" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000988 ! hematopoietic cell -relationship: inheres_in CL:0000988 ! hematopoietic cell +intersection_of: RO:0000052 CL:0000988 ! inheres in hematopoietic cell +relationship: RO:0000052 CL:0000988 ! inheres in hematopoietic cell [Term] id: OBA:0005334 @@ -150915,8 +250270,8 @@ synonym: "morphology of inner cell mass derived hypoblast" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008776 ! inner cell mass derived hypoblast -relationship: inheres_in UBERON:0008776 ! inner cell mass derived hypoblast +intersection_of: RO:0000052 UBERON:0008776 ! inheres in inner cell mass derived hypoblast +relationship: RO:0000052 UBERON:0008776 ! inheres in inner cell mass derived hypoblast [Term] id: OBA:0005335 @@ -150926,8 +250281,8 @@ synonym: "amount of inner cell mass derived epiblast" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008780 ! inner cell mass derived epiblast -relationship: inheres_in UBERON:0008780 ! inner cell mass derived epiblast +intersection_of: RO:0000052 UBERON:0008780 ! inheres in inner cell mass derived epiblast +relationship: RO:0000052 UBERON:0008780 ! inheres in inner cell mass derived epiblast [Term] id: OBA:0005336 @@ -150937,8 +250292,8 @@ synonym: "amount of pigmented ciliary epithelial cell" EXACT [AUTO:patterns/patt is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002303 ! pigmented ciliary epithelial cell -relationship: inheres_in CL:0002303 ! pigmented ciliary epithelial cell +intersection_of: RO:0000052 CL:0002303 ! inheres in pigmented ciliary epithelial cell +relationship: RO:0000052 CL:0002303 ! inheres in pigmented ciliary epithelial cell [Term] id: OBA:0005337 @@ -150947,8 +250302,8 @@ def: "The morphology of a parietal endoderm." [AUTO:patterns/patterns/entity_att synonym: "morphology of parietal endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008800 ! parietal endoderm -relationship: inheres_in UBERON:0008800 ! parietal endoderm +intersection_of: RO:0000052 UBERON:0008800 ! inheres in parietal endoderm +relationship: RO:0000052 UBERON:0008800 ! inheres in parietal endoderm [Term] id: OBA:0005338 @@ -150958,7 +250313,7 @@ synonym: "size of inner cell mass derived epiblast" EXACT [AUTO:patterns/pattern is_a: OBA:VT0003886 ! embryonic epiblast morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008780 ! inner cell mass derived epiblast +intersection_of: RO:0000052 UBERON:0008780 ! inheres in inner cell mass derived epiblast [Term] id: OBA:0005339 @@ -150968,8 +250323,8 @@ synonym: "functionality of hair follicle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002073 ! hair follicle -relationship: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle +relationship: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:0005340 @@ -150979,8 +250334,8 @@ synonym: "morphology of proamniotic cavity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009742 ! proamniotic cavity -relationship: inheres_in UBERON:0009742 ! proamniotic cavity +intersection_of: RO:0000052 UBERON:0009742 ! inheres in proamniotic cavity +relationship: RO:0000052 UBERON:0009742 ! inheres in proamniotic cavity [Term] id: OBA:0005341 @@ -150990,8 +250345,8 @@ synonym: "amount of proamniotic cavity" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009742 ! proamniotic cavity -relationship: inheres_in UBERON:0009742 ! proamniotic cavity +intersection_of: RO:0000052 UBERON:0009742 ! inheres in proamniotic cavity +relationship: RO:0000052 UBERON:0009742 ! inheres in proamniotic cavity [Term] id: OBA:0005342 @@ -151001,8 +250356,8 @@ synonym: "morphology of amniotic cavity" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000301 ! amniotic cavity -relationship: inheres_in UBERON:0000301 ! amniotic cavity +intersection_of: RO:0000052 UBERON:0000301 ! inheres in amniotic cavity +relationship: RO:0000052 UBERON:0000301 ! inheres in amniotic cavity [Term] id: OBA:0005343 @@ -151012,8 +250367,8 @@ synonym: "morphology of extraembryonic coelomic cavity" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003888 ! extraembryonic coelomic cavity -relationship: inheres_in UBERON:0003888 ! extraembryonic coelomic cavity +intersection_of: RO:0000052 UBERON:0003888 ! inheres in extraembryonic coelomic cavity +relationship: RO:0000052 UBERON:0003888 ! inheres in extraembryonic coelomic cavity [Term] id: OBA:0005344 @@ -151023,8 +250378,8 @@ synonym: "morphology of visceral yolk sac cavity" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009743 ! visceral yolk sac cavity -relationship: inheres_in UBERON:0009743 ! visceral yolk sac cavity +intersection_of: RO:0000052 UBERON:0009743 ! inheres in visceral yolk sac cavity +relationship: RO:0000052 UBERON:0009743 ! inheres in visceral yolk sac cavity [Term] id: OBA:0005345 @@ -151034,8 +250389,8 @@ synonym: "morphology of ectoplacental cavity" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008851 ! ectoplacental cavity -relationship: inheres_in UBERON:0008851 ! ectoplacental cavity +intersection_of: RO:0000052 UBERON:0008851 ! inheres in ectoplacental cavity +relationship: RO:0000052 UBERON:0008851 ! inheres in ectoplacental cavity [Term] id: OBA:0005346 @@ -151044,8 +250399,8 @@ def: "The morphology of a parietal yolk sac." [AUTO:patterns/patterns/entity_att synonym: "morphology of parietal yolk sac" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001718 ! yolk sac morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008853 ! parietal yolk sac -relationship: inheres_in UBERON:0008853 ! parietal yolk sac +intersection_of: RO:0000052 UBERON:0008853 ! inheres in parietal yolk sac +relationship: RO:0000052 UBERON:0008853 ! inheres in parietal yolk sac [Term] id: OBA:0005347 @@ -151055,8 +250410,8 @@ synonym: "morphology of yolk sac blood island" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0001721 ! blood island morphology trait is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011919 ! yolk sac blood island -relationship: inheres_in UBERON:0011919 ! yolk sac blood island +intersection_of: RO:0000052 UBERON:0011919 ! inheres in yolk sac blood island +relationship: RO:0000052 UBERON:0011919 ! inheres in yolk sac blood island [Term] id: OBA:0005348 @@ -151066,8 +250421,8 @@ synonym: "surface feature shape of visceral yolk sac" EXACT [AUTO:patterns/patte is_a: OBA:VT0001718 ! yolk sac morphology trait is_a: PATO:0001925 ! surface feature shape intersection_of: PATO:0001925 ! surface feature shape -intersection_of: inheres_in UBERON:0008852 ! visceral yolk sac -relationship: inheres_in UBERON:0008852 ! visceral yolk sac +intersection_of: RO:0000052 UBERON:0008852 ! inheres in visceral yolk sac +relationship: RO:0000052 UBERON:0008852 ! inheres in visceral yolk sac [Term] id: OBA:0005349 @@ -151077,8 +250432,8 @@ synonym: "amount of visceral yolk sac" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008852 ! visceral yolk sac -relationship: inheres_in UBERON:0008852 ! visceral yolk sac +intersection_of: RO:0000052 UBERON:0008852 ! inheres in visceral yolk sac +relationship: RO:0000052 UBERON:0008852 ! inheres in visceral yolk sac [Term] id: OBA:0005350 @@ -151088,8 +250443,8 @@ synonym: "amount of ectoplacental cavity" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008851 ! ectoplacental cavity -relationship: inheres_in UBERON:0008851 ! ectoplacental cavity +intersection_of: RO:0000052 UBERON:0008851 ! inheres in ectoplacental cavity +relationship: RO:0000052 UBERON:0008851 ! inheres in ectoplacental cavity [Term] id: OBA:0005351 @@ -151099,7 +250454,7 @@ synonym: "size of proamniotic cavity" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0005340 ! proamniotic cavity morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009742 ! proamniotic cavity +intersection_of: RO:0000052 UBERON:0009742 ! inheres in proamniotic cavity [Term] id: OBA:0005352 @@ -151109,8 +250464,8 @@ synonym: "amount of extraembryonic coelomic cavity" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003888 ! extraembryonic coelomic cavity -relationship: inheres_in UBERON:0003888 ! extraembryonic coelomic cavity +intersection_of: RO:0000052 UBERON:0003888 ! inheres in extraembryonic coelomic cavity +relationship: RO:0000052 UBERON:0003888 ! inheres in extraembryonic coelomic cavity [Term] id: OBA:0005353 @@ -151120,7 +250475,7 @@ synonym: "morphology of temporomandibular joint" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003754 ! skeletal joint morphology is_a: OBA:1000417 ! temporomandibular joint quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003700 ! temporomandibular joint +intersection_of: RO:0000052 UBERON:0003700 ! inheres in temporomandibular joint [Term] id: OBA:0005354 @@ -151130,8 +250485,8 @@ synonym: "morphology of common fibular nerve" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001324 ! common fibular nerve -relationship: inheres_in UBERON:0001324 ! common fibular nerve +intersection_of: RO:0000052 UBERON:0001324 ! inheres in common fibular nerve +relationship: RO:0000052 UBERON:0001324 ! inheres in common fibular nerve [Term] id: OBA:0005355 @@ -151141,8 +250496,8 @@ synonym: "amount of common fibular nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000471 ! nerve quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001324 ! common fibular nerve -relationship: inheres_in UBERON:0001324 ! common fibular nerve +intersection_of: RO:0000052 UBERON:0001324 ! inheres in common fibular nerve +relationship: RO:0000052 UBERON:0001324 ! inheres in common fibular nerve [Term] id: OBA:0005356 @@ -151152,8 +250507,8 @@ synonym: "morphology of lymph node medullary sinus" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009744 ! lymph node medullary sinus -relationship: inheres_in UBERON:0009744 ! lymph node medullary sinus +intersection_of: RO:0000052 UBERON:0009744 ! inheres in lymph node medullary sinus +relationship: RO:0000052 UBERON:0009744 ! inheres in lymph node medullary sinus [Term] id: OBA:0005357 @@ -151163,7 +250518,7 @@ synonym: "size of lymph node medullary sinus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005356 ! lymph node medullary sinus morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009744 ! lymph node medullary sinus +intersection_of: RO:0000052 UBERON:0009744 ! inheres in lymph node medullary sinus [Term] id: OBA:0005358 @@ -151173,8 +250528,8 @@ synonym: "morphology of lymph node medullary cord" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009745 ! lymph node medullary cord -relationship: inheres_in UBERON:0009745 ! lymph node medullary cord +intersection_of: RO:0000052 UBERON:0009745 ! inheres in lymph node medullary cord +relationship: RO:0000052 UBERON:0009745 ! inheres in lymph node medullary cord [Term] id: OBA:0005359 @@ -151184,7 +250539,7 @@ synonym: "size of lymph node medullary cord" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005358 ! lymph node medullary cord morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009745 ! lymph node medullary cord +intersection_of: RO:0000052 UBERON:0009745 ! inheres in lymph node medullary cord [Term] id: OBA:0005360 @@ -151193,8 +250548,8 @@ def: "The morphology of a fetal derived definitive erythrocyte." [AUTO:patterns/ synonym: "morphology of fetal derived definitive erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002447 ! erythrocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002357 ! fetal derived definitive erythrocyte -relationship: inheres_in CL:0002357 ! fetal derived definitive erythrocyte +intersection_of: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte +relationship: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte [Term] id: OBA:0005361 @@ -151203,8 +250558,8 @@ def: "The amount of a fetal derived definitive erythrocyte." [AUTO:patterns/patt synonym: "amount of fetal derived definitive erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001586 ! erythrocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002357 ! fetal derived definitive erythrocyte -relationship: inheres_in CL:0002357 ! fetal derived definitive erythrocyte +intersection_of: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte +relationship: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte [Term] id: OBA:0005362 @@ -151213,8 +250568,8 @@ def: "The functionality of a fetal derived definitive erythrocyte." [AUTO:patter synonym: "functionality of fetal derived definitive erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003656 ! erythrocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002357 ! fetal derived definitive erythrocyte -relationship: inheres_in CL:0002357 ! fetal derived definitive erythrocyte +intersection_of: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte +relationship: RO:0000052 CL:0002357 ! inheres in fetal derived definitive erythrocyte [Term] id: OBA:0005363 @@ -151223,8 +250578,8 @@ def: "The morphology of a fetal liver hematopoietic progenitor cell." [AUTO:patt synonym: "morphology of fetal liver hematopoietic progenitor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004070 ! hematopoietic stem cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002353 ! fetal liver hematopoietic progenitor cell -relationship: inheres_in CL:0002353 ! fetal liver hematopoietic progenitor cell +intersection_of: RO:0000052 CL:0002353 ! inheres in fetal liver hematopoietic progenitor cell +relationship: RO:0000052 CL:0002353 ! inheres in fetal liver hematopoietic progenitor cell [Term] id: OBA:0005364 @@ -151233,8 +250588,8 @@ def: "The morphology of a yolk sac hematopoietic stem cell." [AUTO:patterns/patt synonym: "morphology of yolk sac hematopoietic stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004070 ! hematopoietic stem cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002354 ! yolk sac hematopoietic stem cell -relationship: inheres_in CL:0002354 ! yolk sac hematopoietic stem cell +intersection_of: RO:0000052 CL:0002354 ! inheres in yolk sac hematopoietic stem cell +relationship: RO:0000052 CL:0002354 ! inheres in yolk sac hematopoietic stem cell [Term] id: OBA:0005365 @@ -151243,8 +250598,8 @@ def: "The morphology of a neural fold." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of neural fold" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005062 ! neural fold -relationship: inheres_in UBERON:0005062 ! neural fold +intersection_of: RO:0000052 UBERON:0005062 ! inheres in neural fold +relationship: RO:0000052 UBERON:0005062 ! inheres in neural fold [Term] id: OBA:0005366 @@ -151253,8 +250608,8 @@ def: "The morphology of a head fold of embryonic disc." [AUTO:patterns/patterns/ synonym: "morphology of head fold of embryonic disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009746 ! head fold of embryonic disc -relationship: inheres_in UBERON:0009746 ! head fold of embryonic disc +intersection_of: RO:0000052 UBERON:0009746 ! inheres in head fold of embryonic disc +relationship: RO:0000052 UBERON:0009746 ! inheres in head fold of embryonic disc [Term] id: OBA:0005367 @@ -151263,8 +250618,8 @@ def: "The morphology of a tail fold of embryonic disc." [AUTO:patterns/patterns/ synonym: "morphology of tail fold of embryonic disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009747 ! tail fold of embryonic disc -relationship: inheres_in UBERON:0009747 ! tail fold of embryonic disc +intersection_of: RO:0000052 UBERON:0009747 ! inheres in tail fold of embryonic disc +relationship: RO:0000052 UBERON:0009747 ! inheres in tail fold of embryonic disc [Term] id: OBA:0005368 @@ -151273,8 +250628,8 @@ def: "The morphology of a cephalic neural fold." [AUTO:patterns/patterns/entity_ synonym: "morphology of cephalic neural fold" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005365 ! neural fold morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009748 ! cephalic neural fold -relationship: inheres_in UBERON:0009748 ! cephalic neural fold +intersection_of: RO:0000052 UBERON:0009748 ! inheres in cephalic neural fold +relationship: RO:0000052 UBERON:0009748 ! inheres in cephalic neural fold [Term] id: OBA:0005369 @@ -151284,8 +250639,8 @@ synonym: "morphology of head mesenchyme" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005253 ! head mesenchyme -relationship: inheres_in UBERON:0005253 ! head mesenchyme +intersection_of: RO:0000052 UBERON:0005253 ! inheres in head mesenchyme +relationship: RO:0000052 UBERON:0005253 ! inheres in head mesenchyme [Term] id: OBA:0005370 @@ -151294,8 +250649,8 @@ def: "The morphology of a limb mesenchyme." [AUTO:patterns/patterns/entity_attri synonym: "morphology of limb mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009749 ! limb mesenchyme -relationship: inheres_in UBERON:0009749 ! limb mesenchyme +intersection_of: RO:0000052 UBERON:0009749 ! inheres in limb mesenchyme +relationship: RO:0000052 UBERON:0009749 ! inheres in limb mesenchyme [Term] id: OBA:0005371 @@ -151304,8 +250659,8 @@ def: "The morphology of a pharyngeal arch mesenchymal region." [AUTO:patterns/pa synonym: "morphology of pharyngeal arch mesenchymal region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005369 ! head mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009494 ! pharyngeal arch mesenchymal region -relationship: inheres_in UBERON:0009494 ! pharyngeal arch mesenchymal region +intersection_of: RO:0000052 UBERON:0009494 ! inheres in pharyngeal arch mesenchymal region +relationship: RO:0000052 UBERON:0009494 ! inheres in pharyngeal arch mesenchymal region [Term] id: OBA:0005372 @@ -151315,8 +250670,8 @@ synonym: "morphology of spleen primordium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006293 ! spleen primordium -relationship: inheres_in UBERON:0006293 ! spleen primordium +intersection_of: RO:0000052 UBERON:0006293 ! inheres in spleen primordium +relationship: RO:0000052 UBERON:0006293 ! inheres in spleen primordium [Term] id: OBA:0005373 @@ -151325,8 +250680,8 @@ def: "The morphology of a cardiac mesenchyme." [AUTO:patterns/patterns/entity_at synonym: "morphology of cardiac mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009751 ! cardiac mesenchyme -relationship: inheres_in UBERON:0009751 ! cardiac mesenchyme +intersection_of: RO:0000052 UBERON:0009751 ! inheres in cardiac mesenchyme +relationship: RO:0000052 UBERON:0009751 ! inheres in cardiac mesenchyme [Term] id: OBA:0005374 @@ -151335,8 +250690,8 @@ def: "The morphology of a pancreas mesenchyme." [AUTO:patterns/patterns/entity_a synonym: "morphology of pancreas mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009752 ! pancreas mesenchyme -relationship: inheres_in UBERON:0009752 ! pancreas mesenchyme +intersection_of: RO:0000052 UBERON:0009752 ! inheres in pancreas mesenchyme +relationship: RO:0000052 UBERON:0009752 ! inheres in pancreas mesenchyme [Term] id: OBA:0005375 @@ -151345,8 +250700,8 @@ def: "The morphology of a mesenchyme of fronto-nasal process." [AUTO:patterns/pa synonym: "morphology of mesenchyme of fronto-nasal process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005369 ! head mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009501 ! mesenchyme of fronto-nasal process -relationship: inheres_in UBERON:0009501 ! mesenchyme of fronto-nasal process +intersection_of: RO:0000052 UBERON:0009501 ! inheres in mesenchyme of fronto-nasal process +relationship: RO:0000052 UBERON:0009501 ! inheres in mesenchyme of fronto-nasal process [Term] id: OBA:0005376 @@ -151356,8 +250711,8 @@ synonym: "amount of nephron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001285 ! nephron -relationship: inheres_in UBERON:0001285 ! nephron +intersection_of: RO:0000052 UBERON:0001285 ! inheres in nephron +relationship: RO:0000052 UBERON:0001285 ! inheres in nephron [Term] id: OBA:0005377 @@ -151367,7 +250722,7 @@ synonym: "size of nephron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003881 ! nephron morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001285 ! nephron +intersection_of: RO:0000052 UBERON:0001285 ! inheres in nephron [Term] id: OBA:0005378 @@ -151376,8 +250731,8 @@ def: "The morphology of a macula densa." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of macula densa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002335 ! macula densa -relationship: inheres_in UBERON:0002335 ! macula densa +intersection_of: RO:0000052 UBERON:0002335 ! inheres in macula densa +relationship: RO:0000052 UBERON:0002335 ! inheres in macula densa [Term] id: OBA:0005379 @@ -151386,8 +250741,8 @@ def: "The morphology of a kidney granular cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of kidney granular cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004087 ! muscle cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000648 ! kidney granular cell -relationship: inheres_in CL:0000648 ! kidney granular cell +intersection_of: RO:0000052 CL:0000648 ! inheres in kidney granular cell +relationship: RO:0000052 CL:0000648 ! inheres in kidney granular cell [Term] id: OBA:0005380 @@ -151396,8 +250751,8 @@ def: "The morphology of a extraglomerular mesangial cell." [AUTO:patterns/patter synonym: "morphology of extraglomerular mesangial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005327 ! mesangial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002173 ! extraglomerular mesangial cell -relationship: inheres_in CL:0002173 ! extraglomerular mesangial cell +intersection_of: RO:0000052 CL:0002173 ! inheres in extraglomerular mesangial cell +relationship: RO:0000052 CL:0002173 ! inheres in extraglomerular mesangial cell [Term] id: OBA:0005381 @@ -151407,8 +250762,8 @@ synonym: "amount of renal papilla" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001228 ! renal papilla -relationship: inheres_in UBERON:0001228 ! renal papilla +intersection_of: RO:0000052 UBERON:0001228 ! inheres in renal papilla +relationship: RO:0000052 UBERON:0001228 ! inheres in renal papilla [Term] id: OBA:0005382 @@ -151418,7 +250773,7 @@ synonym: "size of renal papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004193 ! kidney papilla morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001228 ! renal papilla +intersection_of: RO:0000052 UBERON:0001228 ! inheres in renal papilla [Term] id: OBA:0005383 @@ -151428,7 +250783,7 @@ synonym: "size of kidney calyx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004195 ! calyx morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006517 ! kidney calyx +intersection_of: RO:0000052 UBERON:0006517 ! inheres in kidney calyx [Term] id: OBA:0005384 @@ -151438,7 +250793,7 @@ synonym: "amount of renal pelvis" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000327 ! renal pelvis quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001224 ! renal pelvis +intersection_of: RO:0000052 UBERON:0001224 ! inheres in renal pelvis [Term] id: OBA:0005385 @@ -151447,8 +250802,8 @@ def: "The morphology of a kidney arterial blood vessel." [AUTO:patterns/patterns synonym: "morphology of kidney arterial blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000530 ! kidney blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003644 ! kidney arterial blood vessel -relationship: inheres_in UBERON:0003644 ! kidney arterial blood vessel +intersection_of: RO:0000052 UBERON:0003644 ! inheres in kidney arterial blood vessel +relationship: RO:0000052 UBERON:0003644 ! inheres in kidney arterial blood vessel [Term] id: OBA:0005386 @@ -151458,8 +250813,8 @@ synonym: "morphology of kidney capillary" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000087 ! capillary morphology trait is_a: OBA:VT0000530 ! kidney blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003527 ! kidney capillary -relationship: inheres_in UBERON:0003527 ! kidney capillary +intersection_of: RO:0000052 UBERON:0003527 ! inheres in kidney capillary +relationship: RO:0000052 UBERON:0003527 ! inheres in kidney capillary [Term] id: OBA:0005387 @@ -151468,8 +250823,8 @@ def: "The morphology of a renal venous blood vessel." [AUTO:patterns/patterns/en synonym: "morphology of renal venous blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000530 ! kidney blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014401 ! renal venous blood vessel -relationship: inheres_in UBERON:0014401 ! renal venous blood vessel +intersection_of: RO:0000052 UBERON:0014401 ! inheres in renal venous blood vessel +relationship: RO:0000052 UBERON:0014401 ! inheres in renal venous blood vessel [Term] id: OBA:0005388 @@ -151480,8 +250835,8 @@ is_a: OBA:0003912 ! arteriole morphology is_a: OBA:0005385 ! kidney arterial blood vessel morphology is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004639 ! renal afferent arteriole -relationship: inheres_in UBERON:0004639 ! renal afferent arteriole +intersection_of: RO:0000052 UBERON:0004639 ! inheres in renal afferent arteriole +relationship: RO:0000052 UBERON:0004639 ! inheres in renal afferent arteriole [Term] id: OBA:0005389 @@ -151491,8 +250846,8 @@ synonym: "morphology of renal efferent arteriole" EXACT [AUTO:patterns/patterns/ is_a: OBA:0003912 ! arteriole morphology is_a: OBA:0005385 ! kidney arterial blood vessel morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004640 ! renal efferent arteriole -relationship: inheres_in UBERON:0004640 ! renal efferent arteriole +intersection_of: RO:0000052 UBERON:0004640 ! inheres in renal efferent arteriole +relationship: RO:0000052 UBERON:0004640 ! inheres in renal efferent arteriole [Term] id: OBA:0005390 @@ -151502,8 +250857,8 @@ synonym: "morphology of renal cortex artery" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0005385 ! kidney arterial blood vessel morphology is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005268 ! renal cortex artery -relationship: inheres_in UBERON:0005268 ! renal cortex artery +intersection_of: RO:0000052 UBERON:0005268 ! inheres in renal cortex artery +relationship: RO:0000052 UBERON:0005268 ! inheres in renal cortex artery [Term] id: OBA:0005391 @@ -151513,8 +250868,8 @@ synonym: "morphology of kidney arcuate artery" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0005385 ! kidney arterial blood vessel morphology is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001552 ! kidney arcuate artery -relationship: inheres_in UBERON:0001552 ! kidney arcuate artery +intersection_of: RO:0000052 UBERON:0001552 ! inheres in kidney arcuate artery +relationship: RO:0000052 UBERON:0001552 ! inheres in kidney arcuate artery [Term] id: OBA:0005392 @@ -151523,8 +250878,8 @@ def: "The morphology of a interlobular artery." [AUTO:patterns/patterns/entity_a synonym: "morphology of interlobular artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005385 ! kidney arterial blood vessel morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004723 ! interlobular artery -relationship: inheres_in UBERON:0004723 ! interlobular artery +intersection_of: RO:0000052 UBERON:0004723 ! inheres in interlobular artery +relationship: RO:0000052 UBERON:0004723 ! inheres in interlobular artery [Term] id: OBA:0005393 @@ -151533,8 +250888,8 @@ def: "The morphology of a right renal artery." [AUTO:patterns/patterns/entity_at synonym: "morphology of right renal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010641 ! renal artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001185 ! right renal artery -relationship: inheres_in UBERON:0001185 ! right renal artery +intersection_of: RO:0000052 UBERON:0001185 ! inheres in right renal artery +relationship: RO:0000052 UBERON:0001185 ! inheres in right renal artery [Term] id: OBA:0005394 @@ -151543,8 +250898,8 @@ def: "The morphology of a left renal artery." [AUTO:patterns/patterns/entity_att synonym: "morphology of left renal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010641 ! renal artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001186 ! left renal artery -relationship: inheres_in UBERON:0001186 ! left renal artery +intersection_of: RO:0000052 UBERON:0001186 ! inheres in left renal artery +relationship: RO:0000052 UBERON:0001186 ! inheres in left renal artery [Term] id: OBA:0005395 @@ -151553,8 +250908,8 @@ def: "The morphology of a peritubular capillary." [AUTO:patterns/patterns/entity synonym: "morphology of peritubular capillary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005386 ! kidney capillary morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005272 ! peritubular capillary -relationship: inheres_in UBERON:0005272 ! peritubular capillary +intersection_of: RO:0000052 UBERON:0005272 ! inheres in peritubular capillary +relationship: RO:0000052 UBERON:0005272 ! inheres in peritubular capillary [Term] id: OBA:0005396 @@ -151564,8 +250919,8 @@ synonym: "morphology of renal cortex vein" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005387 ! renal venous blood vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005269 ! renal cortex vein -relationship: inheres_in UBERON:0005269 ! renal cortex vein +intersection_of: RO:0000052 UBERON:0005269 ! inheres in renal cortex vein +relationship: RO:0000052 UBERON:0005269 ! inheres in renal cortex vein [Term] id: OBA:0005397 @@ -151574,8 +250929,8 @@ def: "The morphology of a renal vein." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of renal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001140 ! renal vein -relationship: inheres_in UBERON:0001140 ! renal vein +intersection_of: RO:0000052 UBERON:0001140 ! inheres in renal vein +relationship: RO:0000052 UBERON:0001140 ! inheres in renal vein [Term] id: OBA:0005398 @@ -151584,8 +250939,8 @@ def: "The morphology of a vasa recta." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of vasa recta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005397 ! renal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004726 ! vasa recta -relationship: inheres_in UBERON:0004726 ! vasa recta +intersection_of: RO:0000052 UBERON:0004726 ! inheres in vasa recta +relationship: RO:0000052 UBERON:0004726 ! inheres in vasa recta [Term] id: OBA:0005399 @@ -151595,8 +250950,8 @@ synonym: "morphology of kidney arcuate vein" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0005387 ! renal venous blood vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004719 ! kidney arcuate vein -relationship: inheres_in UBERON:0004719 ! kidney arcuate vein +intersection_of: RO:0000052 UBERON:0004719 ! inheres in kidney arcuate vein +relationship: RO:0000052 UBERON:0004719 ! inheres in kidney arcuate vein [Term] id: OBA:0005400 @@ -151606,8 +250961,8 @@ synonym: "morphology of renal interlobular vein" EXACT [AUTO:patterns/patterns/e is_a: OBA:0005387 ! renal venous blood vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005168 ! renal interlobular vein -relationship: inheres_in UBERON:0005168 ! renal interlobular vein +intersection_of: RO:0000052 UBERON:0005168 ! inheres in renal interlobular vein +relationship: RO:0000052 UBERON:0005168 ! inheres in renal interlobular vein [Term] id: OBA:0005401 @@ -151616,8 +250971,8 @@ def: "The morphology of a left renal vein." [AUTO:patterns/patterns/entity_attri synonym: "morphology of left renal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005397 ! renal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001142 ! left renal vein -relationship: inheres_in UBERON:0001142 ! left renal vein +intersection_of: RO:0000052 UBERON:0001142 ! inheres in left renal vein +relationship: RO:0000052 UBERON:0001142 ! inheres in left renal vein [Term] id: OBA:0005402 @@ -151626,8 +250981,8 @@ def: "The morphology of a right renal vein." [AUTO:patterns/patterns/entity_attr synonym: "morphology of right renal vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005397 ! renal vein morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001141 ! right renal vein -relationship: inheres_in UBERON:0001141 ! right renal vein +intersection_of: RO:0000052 UBERON:0001141 ! inheres in right renal vein +relationship: RO:0000052 UBERON:0001141 ! inheres in right renal vein [Term] id: OBA:0005403 @@ -151637,8 +250992,8 @@ synonym: "morphology of inner renal medulla vasa recta" EXACT [AUTO:patterns/pat is_a: OBA:0005387 ! renal venous blood vessel morphology is_a: OBA:0005398 ! vasa recta morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004776 ! inner renal medulla vasa recta -relationship: inheres_in UBERON:0004776 ! inner renal medulla vasa recta +intersection_of: RO:0000052 UBERON:0004776 ! inheres in inner renal medulla vasa recta +relationship: RO:0000052 UBERON:0004776 ! inheres in inner renal medulla vasa recta [Term] id: OBA:0005404 @@ -151648,8 +251003,8 @@ synonym: "morphology of outer renal medulla vasa recta" EXACT [AUTO:patterns/pat is_a: OBA:0005387 ! renal venous blood vessel morphology is_a: OBA:0005398 ! vasa recta morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004775 ! outer renal medulla vasa recta -relationship: inheres_in UBERON:0004775 ! outer renal medulla vasa recta +intersection_of: RO:0000052 UBERON:0004775 ! inheres in outer renal medulla vasa recta +relationship: RO:0000052 UBERON:0004775 ! inheres in outer renal medulla vasa recta [Term] id: OBA:0005405 @@ -151658,8 +251013,8 @@ def: "The morphology of a papillary duct." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of papillary duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010068 ! kidney collecting duct morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005167 ! papillary duct -relationship: inheres_in UBERON:0005167 ! papillary duct +intersection_of: RO:0000052 UBERON:0005167 ! inheres in papillary duct +relationship: RO:0000052 UBERON:0005167 ! inheres in papillary duct [Term] id: OBA:0005406 @@ -151669,8 +251024,8 @@ synonym: "morphology of outer medulla of kidney" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001293 ! outer medulla of kidney -relationship: inheres_in UBERON:0001293 ! outer medulla of kidney +intersection_of: RO:0000052 UBERON:0001293 ! inheres in outer medulla of kidney +relationship: RO:0000052 UBERON:0001293 ! inheres in outer medulla of kidney [Term] id: OBA:0005407 @@ -151680,8 +251035,8 @@ synonym: "morphology of inner medulla of kidney" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001294 ! inner medulla of kidney -relationship: inheres_in UBERON:0001294 ! inner medulla of kidney +intersection_of: RO:0000052 UBERON:0001294 ! inheres in inner medulla of kidney +relationship: RO:0000052 UBERON:0001294 ! inheres in inner medulla of kidney [Term] id: OBA:0005408 @@ -151691,8 +251046,8 @@ synonym: "morphology of nephrogenic zone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009871 ! nephrogenic zone -relationship: inheres_in UBERON:0009871 ! nephrogenic zone +intersection_of: RO:0000052 UBERON:0009871 ! inheres in nephrogenic zone +relationship: RO:0000052 UBERON:0009871 ! inheres in nephrogenic zone [Term] id: OBA:0005409 @@ -151701,8 +251056,8 @@ def: "The morphology of a kidney pelvis smooth muscle." [AUTO:patterns/patterns/ synonym: "morphology of kidney pelvis smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004227 ! kidney pelvis smooth muscle -relationship: inheres_in UBERON:0004227 ! kidney pelvis smooth muscle +intersection_of: RO:0000052 UBERON:0004227 ! inheres in kidney pelvis smooth muscle +relationship: RO:0000052 UBERON:0004227 ! inheres in kidney pelvis smooth muscle [Term] id: OBA:0005410 @@ -151712,8 +251067,8 @@ synonym: "morphology of kidney pelvis urothelium" EXACT [AUTO:patterns/patterns/ is_a: OBA:0004105 ! kidney epithelium morphology is_a: OBA:VT0003630 ! urothelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004788 ! kidney pelvis urothelium -relationship: inheres_in UBERON:0004788 ! kidney pelvis urothelium +intersection_of: RO:0000052 UBERON:0004788 ! inheres in kidney pelvis urothelium +relationship: RO:0000052 UBERON:0004788 ! inheres in kidney pelvis urothelium [Term] id: OBA:0005411 @@ -151722,8 +251077,8 @@ def: "The morphology of a perihilar interstitium." [AUTO:patterns/patterns/entit synonym: "morphology of perihilar interstitium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005444 ! kidney interstitium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006373 ! perihilar interstitium -relationship: inheres_in UBERON:0006373 ! perihilar interstitium +intersection_of: RO:0000052 UBERON:0006373 ! inheres in perihilar interstitium +relationship: RO:0000052 UBERON:0006373 ! inheres in perihilar interstitium [Term] id: OBA:0005412 @@ -151733,8 +251088,8 @@ synonym: "morphology of glomerular mesangium" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002320 ! glomerular mesangium -relationship: inheres_in UBERON:0002320 ! glomerular mesangium +intersection_of: RO:0000052 UBERON:0002320 ! inheres in glomerular mesangium +relationship: RO:0000052 UBERON:0002320 ! inheres in glomerular mesangium [Term] id: OBA:0005413 @@ -151744,8 +251099,8 @@ synonym: "morphology of extraglomerular mesangium" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002321 ! extraglomerular mesangium -relationship: inheres_in UBERON:0002321 ! extraglomerular mesangium +intersection_of: RO:0000052 UBERON:0002321 ! inheres in extraglomerular mesangium +relationship: RO:0000052 UBERON:0002321 ! inheres in extraglomerular mesangium [Term] id: OBA:0005414 @@ -151754,8 +251109,8 @@ def: "The morphology of a descending limb of loop of Henle." [AUTO:patterns/patt synonym: "morphology of descending limb of loop of Henle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001289 ! descending limb of loop of Henle -relationship: inheres_in UBERON:0001289 ! descending limb of loop of Henle +intersection_of: RO:0000052 UBERON:0001289 ! inheres in descending limb of loop of Henle +relationship: RO:0000052 UBERON:0001289 ! inheres in descending limb of loop of Henle [Term] id: OBA:0005415 @@ -151764,8 +251119,8 @@ def: "The morphology of a ascending limb of loop of Henle." [AUTO:patterns/patte synonym: "morphology of ascending limb of loop of Henle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005164 ! ascending limb of loop of Henle -relationship: inheres_in UBERON:0005164 ! ascending limb of loop of Henle +intersection_of: RO:0000052 UBERON:0005164 ! inheres in ascending limb of loop of Henle +relationship: RO:0000052 UBERON:0005164 ! inheres in ascending limb of loop of Henle [Term] id: OBA:0005416 @@ -151774,8 +251129,8 @@ def: "The morphology of a loop of Henle ascending limb thin segment." [AUTO:patt synonym: "morphology of loop of Henle ascending limb thin segment" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004193 ! loop of Henle ascending limb thin segment -relationship: inheres_in UBERON:0004193 ! loop of Henle ascending limb thin segment +intersection_of: RO:0000052 UBERON:0004193 ! inheres in loop of Henle ascending limb thin segment +relationship: RO:0000052 UBERON:0004193 ! inheres in loop of Henle ascending limb thin segment [Term] id: OBA:0005417 @@ -151784,8 +251139,8 @@ def: "The morphology of a thick ascending limb of loop of Henle." [AUTO:patterns synonym: "morphology of thick ascending limb of loop of Henle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001291 ! thick ascending limb of loop of Henle -relationship: inheres_in UBERON:0001291 ! thick ascending limb of loop of Henle +intersection_of: RO:0000052 UBERON:0001291 ! inheres in thick ascending limb of loop of Henle +relationship: RO:0000052 UBERON:0001291 ! inheres in thick ascending limb of loop of Henle [Term] id: OBA:0005418 @@ -151795,7 +251150,7 @@ synonym: "shape of loop of Henle" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0010066 ! Henle's loop morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001288 ! loop of Henle +intersection_of: RO:0000052 UBERON:0001288 ! inheres in loop of Henle [Term] id: OBA:0005419 @@ -151805,8 +251160,8 @@ synonym: "morphology of medullary ray" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009883 ! medullary ray -relationship: inheres_in UBERON:0009883 ! medullary ray +intersection_of: RO:0000052 UBERON:0009883 ! inheres in medullary ray +relationship: RO:0000052 UBERON:0009883 ! inheres in medullary ray [Term] id: OBA:0005420 @@ -151816,8 +251171,8 @@ synonym: "morphology of glomerular basement membrane" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005777 ! glomerular basement membrane -relationship: inheres_in UBERON:0005777 ! glomerular basement membrane +intersection_of: RO:0000052 UBERON:0005777 ! inheres in glomerular basement membrane +relationship: RO:0000052 UBERON:0005777 ! inheres in glomerular basement membrane [Term] id: OBA:0005421 @@ -151827,7 +251182,7 @@ synonym: "size of mesangial matrix" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000880 ! mesangial matrix quality is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012352 ! mesangial matrix +intersection_of: RO:0000052 UBERON:0012352 ! inheres in mesangial matrix [Term] id: OBA:0005422 @@ -151837,8 +251192,8 @@ synonym: "amount of glomerular tuft" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005749 ! glomerular tuft -relationship: inheres_in UBERON:0005749 ! glomerular tuft +intersection_of: RO:0000052 UBERON:0005749 ! inheres in glomerular tuft +relationship: RO:0000052 UBERON:0005749 ! inheres in glomerular tuft [Term] id: OBA:0005423 @@ -151847,8 +251202,8 @@ def: "The morphology of a interlobar artery." [AUTO:patterns/patterns/entity_att synonym: "morphology of interlobar artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009885 ! interlobar artery -relationship: inheres_in UBERON:0009885 ! interlobar artery +intersection_of: RO:0000052 UBERON:0009885 ! inheres in interlobar artery +relationship: RO:0000052 UBERON:0009885 ! inheres in interlobar artery [Term] id: OBA:0005424 @@ -151858,8 +251213,8 @@ synonym: "amount of renal artery" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001184 ! renal artery -relationship: inheres_in UBERON:0001184 ! renal artery +intersection_of: RO:0000052 UBERON:0001184 ! inheres in renal artery +relationship: RO:0000052 UBERON:0001184 ! inheres in renal artery [Term] id: OBA:0005425 @@ -151868,8 +251223,8 @@ def: "The morphology of a metanephros." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of metanephros" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002135 ! kidney morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000081 ! metanephros -relationship: inheres_in UBERON:0000081 ! metanephros +intersection_of: RO:0000052 UBERON:0000081 ! inheres in metanephros +relationship: RO:0000052 UBERON:0000081 ! inheres in metanephros [Term] id: OBA:0005426 @@ -151878,8 +251233,8 @@ def: "The amount of a metanephros." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of metanephros" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002012 ! kidney amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000081 ! metanephros -relationship: inheres_in UBERON:0000081 ! metanephros +intersection_of: RO:0000052 UBERON:0000081 ! inheres in metanephros +relationship: RO:0000052 UBERON:0000081 ! inheres in metanephros [Term] id: OBA:0005427 @@ -151889,8 +251244,8 @@ synonym: "morphology of kidney corticomedullary boundary" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009917 ! kidney corticomedullary boundary -relationship: inheres_in UBERON:0009917 ! kidney corticomedullary boundary +intersection_of: RO:0000052 UBERON:0009917 ! inheres in kidney corticomedullary boundary +relationship: RO:0000052 UBERON:0009917 ! inheres in kidney corticomedullary boundary [Term] id: OBA:0005428 @@ -151900,8 +251255,8 @@ synonym: "morphology of kidney outer medulla inner stripe" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004201 ! kidney outer medulla inner stripe -relationship: inheres_in UBERON:0004201 ! kidney outer medulla inner stripe +intersection_of: RO:0000052 UBERON:0004201 ! inheres in kidney outer medulla inner stripe +relationship: RO:0000052 UBERON:0004201 ! inheres in kidney outer medulla inner stripe [Term] id: OBA:0005429 @@ -151911,8 +251266,8 @@ synonym: "morphology of kidney outer medulla outer stripe" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004202 ! kidney outer medulla outer stripe -relationship: inheres_in UBERON:0004202 ! kidney outer medulla outer stripe +intersection_of: RO:0000052 UBERON:0004202 ! inheres in kidney outer medulla outer stripe +relationship: RO:0000052 UBERON:0004202 ! inheres in kidney outer medulla outer stripe [Term] id: OBA:0005430 @@ -151922,8 +251277,8 @@ synonym: "morphology of renal lobe" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009913 ! renal lobe -relationship: inheres_in UBERON:0009913 ! renal lobe +intersection_of: RO:0000052 UBERON:0009913 ! inheres in renal lobe +relationship: RO:0000052 UBERON:0009913 ! inheres in renal lobe [Term] id: OBA:0005431 @@ -151933,8 +251288,8 @@ synonym: "morphology of renal lobule" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009914 ! renal lobule -relationship: inheres_in UBERON:0009914 ! renal lobule +intersection_of: RO:0000052 UBERON:0009914 ! inheres in renal lobule +relationship: RO:0000052 UBERON:0009914 ! inheres in renal lobule [Term] id: OBA:0005432 @@ -151943,8 +251298,8 @@ def: "The morphology of a kidney capsule." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of kidney capsule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002015 ! kidney capsule -relationship: inheres_in UBERON:0002015 ! kidney capsule +intersection_of: RO:0000052 UBERON:0002015 ! inheres in kidney capsule +relationship: RO:0000052 UBERON:0002015 ! inheres in kidney capsule [Term] id: OBA:0005433 @@ -151954,8 +251309,8 @@ synonym: "amount of metanephric mesenchyme" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003220 ! metanephric mesenchyme -relationship: inheres_in UBERON:0003220 ! metanephric mesenchyme +intersection_of: RO:0000052 UBERON:0003220 ! inheres in metanephric mesenchyme +relationship: RO:0000052 UBERON:0003220 ! inheres in metanephric mesenchyme [Term] id: OBA:0005434 @@ -151965,8 +251320,8 @@ synonym: "amount of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000948 ! heart -relationship: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart +relationship: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:0005435 @@ -151976,7 +251331,7 @@ synonym: "amount of optic disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000929 ! optic disc quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001783 ! optic disc +intersection_of: RO:0000052 UBERON:0001783 ! inheres in optic disc [Term] id: OBA:0005436 @@ -151985,8 +251340,8 @@ def: "The functionality of a fetal cardiomyocyte." [AUTO:patterns/patterns/entit synonym: "functionality of fetal cardiomyocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003932 ! cardiac muscle cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002495 ! fetal cardiomyocyte -relationship: inheres_in CL:0002495 ! fetal cardiomyocyte +intersection_of: RO:0000052 CL:0002495 ! inheres in fetal cardiomyocyte +relationship: RO:0000052 CL:0002495 ! inheres in fetal cardiomyocyte [Term] id: OBA:0005437 @@ -151996,8 +251351,8 @@ synonym: "pressure of endoneurial fluid" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001025 ! pressure intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0011893 ! endoneurial fluid -relationship: inheres_in UBERON:0011893 ! endoneurial fluid +intersection_of: RO:0000052 UBERON:0011893 ! inheres in endoneurial fluid +relationship: RO:0000052 UBERON:0011893 ! inheres in endoneurial fluid [Term] id: OBA:0005438 @@ -152007,8 +251362,8 @@ synonym: "morphology of retrotrapezoid nucleus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009918 ! retrotrapezoid nucleus -relationship: inheres_in UBERON:0009918 ! retrotrapezoid nucleus +intersection_of: RO:0000052 UBERON:0009918 ! inheres in retrotrapezoid nucleus +relationship: RO:0000052 UBERON:0009918 ! inheres in retrotrapezoid nucleus [Term] id: OBA:0005439 @@ -152018,8 +251373,8 @@ synonym: "amount of nephrogenic zone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0009871 ! nephrogenic zone -relationship: inheres_in UBERON:0009871 ! nephrogenic zone +intersection_of: RO:0000052 UBERON:0009871 ! inheres in nephrogenic zone +relationship: RO:0000052 UBERON:0009871 ! inheres in nephrogenic zone [Term] id: OBA:0005440 @@ -152029,8 +251384,8 @@ synonym: "morphology of gonadal ridge" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005294 ! gonadal ridge -relationship: inheres_in UBERON:0005294 ! gonadal ridge +intersection_of: RO:0000052 UBERON:0005294 ! inheres in gonadal ridge +relationship: RO:0000052 UBERON:0005294 ! inheres in gonadal ridge [Term] id: OBA:0005441 @@ -152040,7 +251395,7 @@ synonym: "size of gonadal ridge" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005440 ! gonadal ridge morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005294 ! gonadal ridge +intersection_of: RO:0000052 UBERON:0005294 ! inheres in gonadal ridge [Term] id: OBA:0005442 @@ -152050,7 +251405,7 @@ synonym: "color pattern of urine" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000056 ! urine trait is_a: PATO:0000019 ! color pattern intersection_of: PATO:0000019 ! color pattern -intersection_of: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:0005443 @@ -152060,8 +251415,8 @@ synonym: "morphology of Leydig cell region of testis" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005212 ! Leydig cell region of testis -relationship: inheres_in UBERON:0005212 ! Leydig cell region of testis +intersection_of: RO:0000052 UBERON:0005212 ! inheres in Leydig cell region of testis +relationship: RO:0000052 UBERON:0005212 ! inheres in Leydig cell region of testis [Term] id: OBA:0005444 @@ -152071,8 +251426,8 @@ synonym: "morphology of kidney interstitium" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005215 ! kidney interstitium -relationship: inheres_in UBERON:0005215 ! kidney interstitium +intersection_of: RO:0000052 UBERON:0005215 ! inheres in kidney interstitium +relationship: RO:0000052 UBERON:0005215 ! inheres in kidney interstitium [Term] id: OBA:0005445 @@ -152081,8 +251436,8 @@ def: "The morphology of a ureter smooth muscle." [AUTO:patterns/patterns/entity_ synonym: "morphology of ureter smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009919 ! ureter smooth muscle -relationship: inheres_in UBERON:0009919 ! ureter smooth muscle +intersection_of: RO:0000052 UBERON:0009919 ! inheres in ureter smooth muscle +relationship: RO:0000052 UBERON:0009919 ! inheres in ureter smooth muscle [Term] id: OBA:0005446 @@ -152092,7 +251447,7 @@ synonym: "size of mesangial cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000055 ! cell size is_a: OBA:VT0005327 ! mesangial cell morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000650 ! mesangial cell +intersection_of: RO:0000052 CL:0000650 ! inheres in mesangial cell [Term] id: OBA:0005447 @@ -152102,7 +251457,7 @@ synonym: "amount of mesangial cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000663 ! mesangial cell quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000650 ! mesangial cell +intersection_of: RO:0000052 CL:0000650 ! inheres in mesangial cell [Term] id: OBA:0005448 @@ -152112,7 +251467,7 @@ synonym: "degeneration of mesangial cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0005327 ! mesangial cell morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in CL:0000650 ! mesangial cell +intersection_of: RO:0000052 CL:0000650 ! inheres in mesangial cell [Term] id: OBA:0005449 @@ -152122,8 +251477,8 @@ synonym: "amount of renal medulla" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000362 ! renal medulla -relationship: inheres_in UBERON:0000362 ! renal medulla +intersection_of: RO:0000052 UBERON:0000362 ! inheres in renal medulla +relationship: RO:0000052 UBERON:0000362 ! inheres in renal medulla [Term] id: OBA:0005450 @@ -152132,8 +251487,8 @@ def: "The amount of a dopaminergic neuron." [AUTO:patterns/patterns/entity_attri synonym: "amount of dopaminergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000700 ! dopaminergic neuron -relationship: inheres_in CL:0000700 ! dopaminergic neuron +intersection_of: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron +relationship: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron [Term] id: OBA:0005451 @@ -152142,8 +251497,8 @@ def: "The displaced of a dopaminergic neuron." [AUTO:patterns/patterns/entity_at synonym: "displaced of dopaminergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005527 ! neuron displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000700 ! dopaminergic neuron -relationship: inheres_in CL:0000700 ! dopaminergic neuron +intersection_of: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron +relationship: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron [Term] id: OBA:0005452 @@ -152153,8 +251508,8 @@ synonym: "morphology of glomerular capillary endothelium" EXACT [AUTO:patterns/p is_a: OBA:0004105 ! kidney epithelium morphology is_a: OBA:0004739 ! blood vessel endothelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004294 ! glomerular capillary endothelium -relationship: inheres_in UBERON:0004294 ! glomerular capillary endothelium +intersection_of: RO:0000052 UBERON:0004294 ! inheres in glomerular capillary endothelium +relationship: RO:0000052 UBERON:0004294 ! inheres in glomerular capillary endothelium [Term] id: OBA:0005453 @@ -152164,8 +251519,8 @@ synonym: "morphology of glomerular endothelium fenestra" EXACT [AUTO:patterns/pa is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0036053 ! glomerular endothelium fenestra -relationship: inheres_in GO:0036053 ! glomerular endothelium fenestra +intersection_of: RO:0000052 GO:0036053 ! inheres in glomerular endothelium fenestra +relationship: RO:0000052 GO:0036053 ! inheres in glomerular endothelium fenestra [Term] id: OBA:0005454 @@ -152175,8 +251530,8 @@ synonym: "amount of glomerular endothelium fenestra" EXACT [AUTO:patterns/patter is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0036053 ! glomerular endothelium fenestra -relationship: inheres_in GO:0036053 ! glomerular endothelium fenestra +intersection_of: RO:0000052 GO:0036053 ! inheres in glomerular endothelium fenestra +relationship: RO:0000052 GO:0036053 ! inheres in glomerular endothelium fenestra [Term] id: OBA:0005455 @@ -152186,8 +251541,8 @@ synonym: "occurrence of ureteric peristalsis" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0072105 ! ureteric peristalsis -relationship: inheres_in GO:0072105 ! ureteric peristalsis +intersection_of: RO:0000052 GO:0072105 ! inheres in ureteric peristalsis +relationship: RO:0000052 GO:0072105 ! inheres in ureteric peristalsis [Term] id: OBA:0005456 @@ -152196,8 +251551,8 @@ def: "The morphology of a urothelium of ureter." [AUTO:patterns/patterns/entity_ synonym: "morphology of urothelium of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003630 ! urothelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001254 ! urothelium of ureter -relationship: inheres_in UBERON:0001254 ! urothelium of ureter +intersection_of: RO:0000052 UBERON:0001254 ! inheres in urothelium of ureter +relationship: RO:0000052 UBERON:0001254 ! inheres in urothelium of ureter [Term] id: OBA:0005457 @@ -152206,8 +251561,8 @@ def: "The morphology of a urethra urothelium." [AUTO:patterns/patterns/entity_at synonym: "morphology of urethra urothelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003630 ! urothelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004787 ! urethra urothelium -relationship: inheres_in UBERON:0004787 ! urethra urothelium +intersection_of: RO:0000052 UBERON:0004787 ! inheres in urethra urothelium +relationship: RO:0000052 UBERON:0004787 ! inheres in urethra urothelium [Term] id: OBA:0005458 @@ -152217,8 +251572,8 @@ synonym: "displaced of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000056 ! ureter -relationship: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter +relationship: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0005459 @@ -152228,8 +251583,8 @@ synonym: "morphology of ureteropelvic junction" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009972 ! ureteropelvic junction -relationship: inheres_in UBERON:0009972 ! ureteropelvic junction +intersection_of: RO:0000052 UBERON:0009972 ! inheres in ureteropelvic junction +relationship: RO:0000052 UBERON:0009972 ! inheres in ureteropelvic junction [Term] id: OBA:0005460 @@ -152239,8 +251594,8 @@ synonym: "morphology of ureterovesical junction" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009973 ! ureterovesical junction -relationship: inheres_in UBERON:0009973 ! ureterovesical junction +intersection_of: RO:0000052 UBERON:0009973 ! inheres in ureterovesical junction +relationship: RO:0000052 UBERON:0009973 ! inheres in ureterovesical junction [Term] id: OBA:0005461 @@ -152250,7 +251605,7 @@ synonym: "closure of ureteropelvic junction" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0005459 ! ureteropelvic junction morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0009972 ! ureteropelvic junction +intersection_of: RO:0000052 UBERON:0009972 ! inheres in ureteropelvic junction [Term] id: OBA:0005462 @@ -152260,7 +251615,7 @@ synonym: "structure of ureteropelvic junction" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0005459 ! ureteropelvic junction morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0009972 ! ureteropelvic junction +intersection_of: RO:0000052 UBERON:0009972 ! inheres in ureteropelvic junction [Term] id: OBA:0005463 @@ -152270,18 +251625,18 @@ synonym: "amount of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000056 ! ureter -relationship: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter +relationship: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:0005464 -name: visceral layer of glomerular capsule morphology -def: "The morphology of a visceral layer of glomerular capsule." [AUTO:patterns/patterns/entity_attribute] -synonym: "morphology of visceral layer of glomerular capsule" EXACT [AUTO:patterns/patterns/entity_attribute] +name: glomerular visceral epithelium morphology +def: "The morphology of a glomerular visceral epithelium." [AUTO:patterns/patterns/entity_attribute] +synonym: "morphology of glomerular visceral epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005751 ! visceral layer of glomerular capsule -relationship: inheres_in UBERON:0005751 ! visceral layer of glomerular capsule +intersection_of: RO:0000052 UBERON:0005751 ! inheres in glomerular visceral epithelium +relationship: RO:0000052 UBERON:0005751 ! inheres in glomerular visceral epithelium [Term] id: OBA:0005465 @@ -152290,8 +251645,8 @@ def: "The morphology of a glomerular parietal epithelium." [AUTO:patterns/patter synonym: "morphology of glomerular parietal epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005750 ! glomerular parietal epithelium -relationship: inheres_in UBERON:0005750 ! glomerular parietal epithelium +intersection_of: RO:0000052 UBERON:0005750 ! inheres in glomerular parietal epithelium +relationship: RO:0000052 UBERON:0005750 ! inheres in glomerular parietal epithelium [Term] id: OBA:0005466 @@ -152301,8 +251656,8 @@ synonym: "morphology of Bowman's space" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001286 ! Bowman's space -relationship: inheres_in UBERON:0001286 ! Bowman's space +intersection_of: RO:0000052 UBERON:0001286 ! inheres in Bowman's space +relationship: RO:0000052 UBERON:0001286 ! inheres in Bowman's space [Term] id: OBA:0005467 @@ -152312,7 +251667,7 @@ synonym: "size of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004002 ! jejunum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002115 ! jejunum +intersection_of: RO:0000052 UBERON:0002115 ! inheres in jejunum [Term] id: OBA:0005468 @@ -152323,8 +251678,8 @@ is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0003723 ! long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003606 ! limb long bone -relationship: inheres_in UBERON:0003606 ! limb long bone +intersection_of: RO:0000052 UBERON:0003606 ! inheres in limb long bone +relationship: RO:0000052 UBERON:0003606 ! inheres in limb long bone [Term] id: OBA:0005469 @@ -152334,7 +251689,7 @@ synonym: "shape of limb long bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002163 ! long bone shape is_a: OBA:0005468 ! limb long bone morphology intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0003606 ! limb long bone +intersection_of: RO:0000052 UBERON:0003606 ! inheres in limb long bone [Term] id: OBA:0005470 @@ -152344,7 +251699,7 @@ synonym: "size of glomerular capillary" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0005325 ! glomerulus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004212 ! glomerular capillary +intersection_of: RO:0000052 UBERON:0004212 ! inheres in glomerular capillary [Term] id: OBA:0005471 @@ -152354,7 +251709,7 @@ synonym: "morphology of vertebral artery" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0005507 ! systemic artery morphology is_a: OBA:1000530 ! vertebral artery quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001535 ! vertebral artery +intersection_of: RO:0000052 UBERON:0001535 ! inheres in vertebral artery [Term] id: OBA:0005472 @@ -152364,8 +251719,8 @@ synonym: "morphology of placental labyrinth villous" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010005 ! placental labyrinth villous -relationship: inheres_in UBERON:0010005 ! placental labyrinth villous +intersection_of: RO:0000052 UBERON:0010005 ! inheres in placental labyrinth villous +relationship: RO:0000052 UBERON:0010005 ! inheres in placental labyrinth villous [Term] id: OBA:0005473 @@ -152375,8 +251730,8 @@ synonym: "morphology of placenta intervillous maternal lacunae" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010006 ! placenta intervillous maternal lacunae -relationship: inheres_in UBERON:0010006 ! placenta intervillous maternal lacunae +intersection_of: RO:0000052 UBERON:0010006 ! inheres in placenta intervillous maternal lacunae +relationship: RO:0000052 UBERON:0010006 ! inheres in placenta intervillous maternal lacunae [Term] id: OBA:0005474 @@ -152386,8 +251741,8 @@ synonym: "morphology of placenta fetal blood space" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010007 ! placenta fetal blood space -relationship: inheres_in UBERON:0010007 ! placenta fetal blood space +intersection_of: RO:0000052 UBERON:0010007 ! inheres in placenta fetal blood space +relationship: RO:0000052 UBERON:0010007 ! inheres in placenta fetal blood space [Term] id: OBA:0005475 @@ -152397,7 +251752,7 @@ synonym: "organization quality of placenta labyrinth" EXACT [AUTO:patterns/patte is_a: OBA:VT0001716 ! placenta labyrinth morphology trait is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in UBERON:0003946 ! placenta labyrinth +intersection_of: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth [Term] id: OBA:0005476 @@ -152407,7 +251762,7 @@ synonym: "size of placenta intervillous maternal lacunae" EXACT [AUTO:patterns/p is_a: OBA:0005473 ! placenta intervillous maternal lacunae morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010006 ! placenta intervillous maternal lacunae +intersection_of: RO:0000052 UBERON:0010006 ! inheres in placenta intervillous maternal lacunae [Term] id: OBA:0005477 @@ -152416,8 +251771,8 @@ def: "The morphology of a syncytiotrophoblast cell." [AUTO:patterns/patterns/ent synonym: "morphology of syncytiotrophoblast cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000525 ! syncytiotrophoblast cell -relationship: inheres_in CL:0000525 ! syncytiotrophoblast cell +intersection_of: RO:0000052 CL:0000525 ! inheres in syncytiotrophoblast cell +relationship: RO:0000052 CL:0000525 ! inheres in syncytiotrophoblast cell [Term] id: OBA:0005478 @@ -152426,8 +251781,8 @@ def: "The morphology of a azygos vein." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of azygos vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001594 ! azygos vein -relationship: inheres_in UBERON:0001594 ! azygos vein +intersection_of: RO:0000052 UBERON:0001594 ! inheres in azygos vein +relationship: RO:0000052 UBERON:0001594 ! inheres in azygos vein [Term] id: OBA:0005479 @@ -152437,7 +251792,7 @@ synonym: "size of valve of inferior vena cava" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003470 ! cardial valve size is_a: OBA:0005068 ! valve of inferior vena cava morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005485 ! valve of inferior vena cava +intersection_of: RO:0000052 UBERON:0005485 ! inheres in valve of inferior vena cava [Term] id: OBA:0005480 @@ -152447,8 +251802,8 @@ synonym: "morphology of bulb of aorta" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010172 ! bulb of aorta -relationship: inheres_in UBERON:0010172 ! bulb of aorta +intersection_of: RO:0000052 UBERON:0010172 ! inheres in bulb of aorta +relationship: RO:0000052 UBERON:0010172 ! inheres in bulb of aorta [Term] id: OBA:0005481 @@ -152458,8 +251813,8 @@ synonym: "morphology of sinotubular junction" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010173 ! sinotubular junction -relationship: inheres_in UBERON:0010173 ! sinotubular junction +intersection_of: RO:0000052 UBERON:0010173 ! inheres in sinotubular junction +relationship: RO:0000052 UBERON:0010173 ! inheres in sinotubular junction [Term] id: OBA:0005482 @@ -152469,7 +251824,7 @@ synonym: "size of sinotubular junction" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005481 ! sinotubular junction morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010173 ! sinotubular junction +intersection_of: RO:0000052 UBERON:0010173 ! inheres in sinotubular junction [Term] id: OBA:0005483 @@ -152479,7 +251834,7 @@ synonym: "size of bulb of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005480 ! bulb of aorta morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0010172 ! bulb of aorta +intersection_of: RO:0000052 UBERON:0010172 ! inheres in bulb of aorta [Term] id: OBA:0005484 @@ -152488,8 +251843,8 @@ def: "The amount of a vertebral bone 1." [AUTO:patterns/patterns/entity_attribut synonym: "amount of vertebral bone 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002371 ! vertebra amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001092 ! vertebral bone 1 -relationship: inheres_in UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0000052 UBERON:0001092 ! inheres in vertebral bone 1 +relationship: RO:0000052 UBERON:0001092 ! inheres in vertebral bone 1 [Term] id: OBA:0005485 @@ -152499,7 +251854,7 @@ synonym: "rate of lipoprotein lipase activity" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0005486 ! triglyceride lipase activity rate is_a: OBA:1000849 ! lipoprotein lipase activity quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004465 ! lipoprotein lipase activity +intersection_of: RO:0000052 GO:0004465 ! inheres in lipoprotein lipase activity [Term] id: OBA:0005486 @@ -152509,7 +251864,7 @@ synonym: "rate of triglyceride lipase activity" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000909 ! triglyceride lipase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004806 ! triglyceride lipase activity +intersection_of: RO:0000052 GO:0004806 ! inheres in triglyceride lipase activity [Term] id: OBA:0005487 @@ -152519,7 +251874,7 @@ synonym: "rate of alkaline phosphatase activity" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000448 ! alkaline phosphatase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004035 ! alkaline phosphatase activity +intersection_of: RO:0000052 GO:0004035 ! inheres in alkaline phosphatase activity [Term] id: OBA:0005488 @@ -152529,7 +251884,7 @@ synonym: "rate of ornithine carbamoyltransferase activity" EXACT [AUTO:patterns/ is_a: OBA:1000655 ! ornithine carbamoyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity +intersection_of: RO:0000052 GO:0004585 ! inheres in ornithine carbamoyltransferase activity [Term] id: OBA:0005489 @@ -152539,7 +251894,7 @@ synonym: "rate of purine-nucleoside phosphorylase activity" EXACT [AUTO:patterns is_a: OBA:1000703 ! purine-nucleoside phosphorylase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004731 ! purine-nucleoside phosphorylase activity +intersection_of: RO:0000052 GO:0004731 ! inheres in purine-nucleoside phosphorylase activity [Term] id: OBA:0005490 @@ -152549,7 +251904,7 @@ synonym: "rate of phosphatidylcholine-sterol O-acyltransferase activity" EXACT [ is_a: OBA:1000904 ! phosphatidylcholine-sterol O-acyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004607 ! phosphatidylcholine-sterol O-acyltransferase activity +intersection_of: RO:0000052 GO:0004607 ! inheres in phosphatidylcholine-sterol O-acyltransferase activity [Term] id: OBA:0005491 @@ -152559,7 +251914,7 @@ synonym: "rate of glutathione peroxidase activity" EXACT [AUTO:patterns/patterns is_a: OBA:0005697 ! peroxidase activity rate is_a: OBA:1000797 ! glutathione peroxidase activity quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004602 ! glutathione peroxidase activity +intersection_of: RO:0000052 GO:0004602 ! inheres in glutathione peroxidase activity [Term] id: OBA:0005492 @@ -152569,7 +251924,7 @@ synonym: "rate of glucokinase activity" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000732 ! glucokinase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004340 ! glucokinase activity +intersection_of: RO:0000052 GO:0004340 ! inheres in glucokinase activity [Term] id: OBA:0005493 @@ -152579,7 +251934,7 @@ synonym: "rate of glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylati is_a: OBA:1000789 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity +intersection_of: RO:0000052 GO:0004365 ! inheres in glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Term] id: OBA:0005494 @@ -152589,8 +251944,8 @@ synonym: "rate of aging" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0007568 ! aging -relationship: inheres_in GO:0007568 ! aging +intersection_of: RO:0000052 GO:0007568 ! inheres in aging +relationship: RO:0000052 GO:0007568 ! inheres in aging [Term] id: OBA:0005495 @@ -152600,7 +251955,7 @@ synonym: "size of mitochondrion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:0002821 ! mitochondrion morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0005739 ! mitochondrion +intersection_of: RO:0000052 GO:0005739 ! inheres in mitochondrion [Term] id: OBA:0005496 @@ -152609,8 +251964,8 @@ def: "The morphology of a mitochondrial inner membrane." [AUTO:patterns/patterns synonym: "morphology of mitochondrial inner membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000091 ! membrane morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005743 ! mitochondrial inner membrane -relationship: inheres_in GO:0005743 ! mitochondrial inner membrane +intersection_of: RO:0000052 GO:0005743 ! inheres in mitochondrial inner membrane +relationship: RO:0000052 GO:0005743 ! inheres in mitochondrial inner membrane [Term] id: OBA:0005497 @@ -152620,8 +251975,8 @@ synonym: "morphology of mitochondrial crista" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030061 ! mitochondrial crista -relationship: inheres_in GO:0030061 ! mitochondrial crista +intersection_of: RO:0000052 GO:0030061 ! inheres in mitochondrial crista +relationship: RO:0000052 GO:0030061 ! inheres in mitochondrial crista [Term] id: OBA:0005498 @@ -152631,7 +251986,7 @@ synonym: "organization quality of mitochondrial crista" EXACT [AUTO:patterns/pat is_a: OBA:0005497 ! mitochondrial crista morphology is_a: PATO:0002264 ! organization quality intersection_of: PATO:0002264 ! organization quality -intersection_of: inheres_in GO:0030061 ! mitochondrial crista +intersection_of: RO:0000052 GO:0030061 ! inheres in mitochondrial crista [Term] id: OBA:0005499 @@ -152641,8 +251996,8 @@ synonym: "morphology of mitochondrial matrix" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005759 ! mitochondrial matrix -relationship: inheres_in GO:0005759 ! mitochondrial matrix +intersection_of: RO:0000052 GO:0005759 ! inheres in mitochondrial matrix +relationship: RO:0000052 GO:0005759 ! inheres in mitochondrial matrix [Term] id: OBA:0005500 @@ -152651,8 +252006,8 @@ def: "The morphology of a mitochondrial chromosome." [AUTO:patterns/patterns/ent synonym: "morphology of mitochondrial chromosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003856 ! chromosome morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0000262 ! mitochondrial chromosome -relationship: inheres_in GO:0000262 ! mitochondrial chromosome +intersection_of: RO:0000052 GO:0000262 ! inheres in mitochondrial chromosome +relationship: RO:0000052 GO:0000262 ! inheres in mitochondrial chromosome [Term] id: OBA:0005501 @@ -152662,8 +252017,8 @@ synonym: "morphology of aorta collagen fibril" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011861 ! aorta collagen fibril -relationship: inheres_in UBERON:0011861 ! aorta collagen fibril +intersection_of: RO:0000052 UBERON:0011861 ! inheres in aorta collagen fibril +relationship: RO:0000052 UBERON:0011861 ! inheres in aorta collagen fibril [Term] id: OBA:0005502 @@ -152673,8 +252028,8 @@ synonym: "morphology of pulmonary collagen fibril" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011862 ! pulmonary collagen fibril -relationship: inheres_in UBERON:0011862 ! pulmonary collagen fibril +intersection_of: RO:0000052 UBERON:0011862 ! inheres in pulmonary collagen fibril +relationship: RO:0000052 UBERON:0011862 ! inheres in pulmonary collagen fibril [Term] id: OBA:0005503 @@ -152684,8 +252039,8 @@ synonym: "morphology of tendon collagen fibril" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011864 ! tendon collagen fibril -relationship: inheres_in UBERON:0011864 ! tendon collagen fibril +intersection_of: RO:0000052 UBERON:0011864 ! inheres in tendon collagen fibril +relationship: RO:0000052 UBERON:0011864 ! inheres in tendon collagen fibril [Term] id: OBA:0005504 @@ -152694,8 +252049,8 @@ def: "The morphology of a sinoatrial valve." [AUTO:patterns/patterns/entity_attr synonym: "morphology of sinoatrial valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002086 ! sinoatrial valve -relationship: inheres_in UBERON:0002086 ! sinoatrial valve +intersection_of: RO:0000052 UBERON:0002086 ! inheres in sinoatrial valve +relationship: RO:0000052 UBERON:0002086 ! inheres in sinoatrial valve [Term] id: OBA:0005505 @@ -152705,8 +252060,8 @@ synonym: "amount of sinoatrial valve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002086 ! sinoatrial valve -relationship: inheres_in UBERON:0002086 ! sinoatrial valve +intersection_of: RO:0000052 UBERON:0002086 ! inheres in sinoatrial valve +relationship: RO:0000052 UBERON:0002086 ! inheres in sinoatrial valve [Term] id: OBA:0005506 @@ -152716,8 +252071,8 @@ synonym: "morphology of corneal stroma collagen fibril" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011865 ! corneal stroma collagen fibril -relationship: inheres_in UBERON:0011865 ! corneal stroma collagen fibril +intersection_of: RO:0000052 UBERON:0011865 ! inheres in corneal stroma collagen fibril +relationship: RO:0000052 UBERON:0011865 ! inheres in corneal stroma collagen fibril [Term] id: OBA:0005507 @@ -152726,8 +252081,8 @@ def: "The morphology of a systemic artery." [AUTO:patterns/patterns/entity_attri synonym: "morphology of systemic artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004573 ! systemic artery -relationship: inheres_in UBERON:0004573 ! systemic artery +intersection_of: RO:0000052 UBERON:0004573 ! inheres in systemic artery +relationship: RO:0000052 UBERON:0004573 ! inheres in systemic artery [Term] id: OBA:0005508 @@ -152736,8 +252091,8 @@ def: "The functionality of a olfactory receptor cell." [AUTO:patterns/patterns/e synonym: "functionality of olfactory receptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004983 ! sensory neuron functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000207 ! olfactory receptor cell -relationship: inheres_in CL:0000207 ! olfactory receptor cell +intersection_of: RO:0000052 CL:0000207 ! inheres in olfactory receptor cell +relationship: RO:0000052 CL:0000207 ! inheres in olfactory receptor cell [Term] id: OBA:0005509 @@ -152746,8 +252101,8 @@ def: "The functionality of a vomeronasal sensory neuron." [AUTO:patterns/pattern synonym: "functionality of vomeronasal sensory neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004983 ! sensory neuron functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:1001561 ! vomeronasal sensory neuron -relationship: inheres_in CL:1001561 ! vomeronasal sensory neuron +intersection_of: RO:0000052 CL:1001561 ! inheres in vomeronasal sensory neuron +relationship: RO:0000052 CL:1001561 ! inheres in vomeronasal sensory neuron [Term] id: OBA:0005510 @@ -152756,8 +252111,8 @@ def: "The morphology of a vomeronasal sensory neuron." [AUTO:patterns/patterns/e synonym: "morphology of vomeronasal sensory neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001561 ! vomeronasal sensory neuron -relationship: inheres_in CL:1001561 ! vomeronasal sensory neuron +intersection_of: RO:0000052 CL:1001561 ! inheres in vomeronasal sensory neuron +relationship: RO:0000052 CL:1001561 ! inheres in vomeronasal sensory neuron [Term] id: OBA:0005511 @@ -152767,7 +252122,7 @@ synonym: "structure of cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0003105 ! heart atrium morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002081 ! cardiac atrium +intersection_of: RO:0000052 UBERON:0002081 ! inheres in cardiac atrium [Term] id: OBA:0005512 @@ -152777,8 +252132,8 @@ synonym: "amount of posterior vena cava" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000524 ! vena cava quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001072 ! posterior vena cava -relationship: inheres_in UBERON:0001072 ! posterior vena cava +intersection_of: RO:0000052 UBERON:0001072 ! inheres in posterior vena cava +relationship: RO:0000052 UBERON:0001072 ! inheres in posterior vena cava [Term] id: OBA:0005513 @@ -152788,8 +252143,8 @@ synonym: "morphology of limb paddle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012300 ! limb paddle -relationship: inheres_in UBERON:0012300 ! limb paddle +intersection_of: RO:0000052 UBERON:0012300 ! inheres in limb paddle +relationship: RO:0000052 UBERON:0012300 ! inheres in limb paddle [Term] id: OBA:0005514 @@ -152799,8 +252154,8 @@ synonym: "amount of stem cell of epidermis" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1000428 ! stem cell of epidermis -relationship: inheres_in CL:1000428 ! stem cell of epidermis +intersection_of: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis +relationship: RO:0000052 CL:1000428 ! inheres in stem cell of epidermis [Term] id: OBA:0005515 @@ -152810,8 +252165,8 @@ synonym: "amount of bronchioalveolar stem cells" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1001566 ! bronchioalveolar stem cells -relationship: inheres_in CL:1001566 ! bronchioalveolar stem cells +intersection_of: RO:0000052 CL:1001566 ! inheres in bronchioalveolar stem cells +relationship: RO:0000052 CL:1001566 ! inheres in bronchioalveolar stem cells [Term] id: OBA:0005516 @@ -152821,7 +252176,7 @@ synonym: "structure of lens of camera-type eye" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0001303 ! lens morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:0005517 @@ -152830,8 +252185,8 @@ def: "The functionality of a brown adipose tissue." [AUTO:patterns/patterns/enti synonym: "functionality of brown adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004166 ! adipose tissue functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001348 ! brown adipose tissue -relationship: inheres_in UBERON:0001348 ! brown adipose tissue +intersection_of: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue +relationship: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue [Term] id: OBA:0005518 @@ -152841,7 +252196,7 @@ synonym: "rate of ovarian cumulus expansion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002215 ! growth rate is_a: OBA:1000902 ! ovarian cumulus expansion quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001550 ! ovarian cumulus expansion +intersection_of: RO:0000052 GO:0001550 ! inheres in ovarian cumulus expansion [Term] id: OBA:0005519 @@ -152851,7 +252206,7 @@ synonym: "occurrence of ovarian cumulus expansion" EXACT [AUTO:patterns/patterns is_a: OBA:1000902 ! ovarian cumulus expansion quality is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0001550 ! ovarian cumulus expansion +intersection_of: RO:0000052 GO:0001550 ! inheres in ovarian cumulus expansion [Term] id: OBA:0005520 @@ -152860,8 +252215,8 @@ def: "The rate of a fibroblast proliferation." [AUTO:patterns/patterns/entity_at synonym: "rate of fibroblast proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048144 ! fibroblast proliferation -relationship: inheres_in GO:0048144 ! fibroblast proliferation +intersection_of: RO:0000052 GO:0048144 ! inheres in fibroblast proliferation +relationship: RO:0000052 GO:0048144 ! inheres in fibroblast proliferation [Term] id: OBA:0005521 @@ -152871,8 +252226,8 @@ synonym: "amount of fibroblast proliferation" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0048144 ! fibroblast proliferation -relationship: inheres_in GO:0048144 ! fibroblast proliferation +intersection_of: RO:0000052 GO:0048144 ! inheres in fibroblast proliferation +relationship: RO:0000052 GO:0048144 ! inheres in fibroblast proliferation [Term] id: OBA:0005522 @@ -152882,8 +252237,8 @@ synonym: "occurrence of fibroblast migration" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0010761 ! fibroblast migration -relationship: inheres_in GO:0010761 ! fibroblast migration +intersection_of: RO:0000052 GO:0010761 ! inheres in fibroblast migration +relationship: RO:0000052 GO:0010761 ! inheres in fibroblast migration [Term] id: OBA:0005523 @@ -152892,8 +252247,8 @@ def: "The rate of a fibroblast migration." [AUTO:patterns/patterns/entity_attrib synonym: "rate of fibroblast migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005563 ! cell migration rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0010761 ! fibroblast migration -relationship: inheres_in GO:0010761 ! fibroblast migration +intersection_of: RO:0000052 GO:0010761 ! inheres in fibroblast migration +relationship: RO:0000052 GO:0010761 ! inheres in fibroblast migration [Term] id: OBA:0005524 @@ -152903,8 +252258,8 @@ synonym: "rate of osteoblast differentiation" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001649 ! osteoblast differentiation -relationship: inheres_in GO:0001649 ! osteoblast differentiation +intersection_of: RO:0000052 GO:0001649 ! inheres in osteoblast differentiation +relationship: RO:0000052 GO:0001649 ! inheres in osteoblast differentiation [Term] id: OBA:0005525 @@ -152914,8 +252269,8 @@ synonym: "amount of osteoblast differentiation" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001649 ! osteoblast differentiation -relationship: inheres_in GO:0001649 ! osteoblast differentiation +intersection_of: RO:0000052 GO:0001649 ! inheres in osteoblast differentiation +relationship: RO:0000052 GO:0001649 ! inheres in osteoblast differentiation [Term] id: OBA:0005526 @@ -152925,8 +252280,8 @@ synonym: "rate of interleukin-8 production" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0032637 ! interleukin-8 production -relationship: inheres_in GO:0032637 ! interleukin-8 production +intersection_of: RO:0000052 GO:0032637 ! inheres in interleukin-8 production +relationship: RO:0000052 GO:0032637 ! inheres in interleukin-8 production [Term] id: OBA:0005527 @@ -152935,18 +252290,18 @@ def: "The displaced of a neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "displaced of neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002311 ! neural cell displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000540 ! neuron -relationship: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron +relationship: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:0005528 -name: obsolete neuron of cerebral cortex displaced -def: "The displaced of a obsolete neuron of cerebral cortex." [AUTO:patterns/patterns/entity_attribute] -synonym: "displaced of obsolete neuron of cerebral cortex" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: PATO:0002181 ! displaced +name: cerebral cortex neuron displaced +def: "The displaced of a cerebral cortex neuron." [AUTO:patterns/patterns/entity_attribute] +synonym: "displaced of cerebral cortex neuron" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0005527 ! neuron displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0002609 ! obsolete neuron of cerebral cortex -relationship: inheres_in CL:0002609 ! obsolete neuron of cerebral cortex +intersection_of: RO:0000052 CL:0010012 ! inheres in cerebral cortex neuron +relationship: RO:0000052 CL:0010012 ! inheres in cerebral cortex neuron [Term] id: OBA:0005529 @@ -152955,8 +252310,8 @@ def: "The displaced of a Cajal-Retzius cell." [AUTO:patterns/patterns/entity_att synonym: "displaced of Cajal-Retzius cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005527 ! neuron displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000695 ! Cajal-Retzius cell -relationship: inheres_in CL:0000695 ! Cajal-Retzius cell +intersection_of: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell +relationship: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell [Term] id: OBA:0005530 @@ -152966,7 +252321,7 @@ synonym: "displaced of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000545 ! ovary quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:0005531 @@ -152976,7 +252331,7 @@ synonym: "size of myelin sheath" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:0003880 ! myelin sheath morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0043209 ! myelin sheath +intersection_of: RO:0000052 GO:0043209 ! inheres in myelin sheath [Term] id: OBA:0005532 @@ -152985,8 +252340,8 @@ def: "The morphology of a Boettcher cell." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of Boettcher cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002084 ! Boettcher cell -relationship: inheres_in CL:0002084 ! Boettcher cell +intersection_of: RO:0000052 CL:0002084 ! inheres in Boettcher cell +relationship: RO:0000052 CL:0002084 ! inheres in Boettcher cell [Term] id: OBA:0005533 @@ -152996,8 +252351,8 @@ synonym: "morphology of seminiferous tubule epithelium" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004813 ! seminiferous tubule epithelium -relationship: inheres_in UBERON:0004813 ! seminiferous tubule epithelium +intersection_of: RO:0000052 UBERON:0004813 ! inheres in seminiferous tubule epithelium +relationship: RO:0000052 UBERON:0004813 ! inheres in seminiferous tubule epithelium [Term] id: OBA:0005534 @@ -153006,8 +252361,8 @@ def: "The morphology of a kidney collecting duct intercalated cell." [AUTO:patte synonym: "morphology of kidney collecting duct intercalated cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001432 ! kidney collecting duct intercalated cell -relationship: inheres_in CL:1001432 ! kidney collecting duct intercalated cell +intersection_of: RO:0000052 CL:1001432 ! inheres in kidney collecting duct intercalated cell +relationship: RO:0000052 CL:1001432 ! inheres in kidney collecting duct intercalated cell [Term] id: OBA:0005535 @@ -153016,8 +252371,8 @@ def: "The morphology of a kidney collecting duct principal cell." [AUTO:patterns synonym: "morphology of kidney collecting duct principal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001431 ! kidney collecting duct principal cell -relationship: inheres_in CL:1001431 ! kidney collecting duct principal cell +intersection_of: RO:0000052 CL:1001431 ! inheres in kidney collecting duct principal cell +relationship: RO:0000052 CL:1001431 ! inheres in kidney collecting duct principal cell [Term] id: OBA:0005536 @@ -153027,7 +252382,7 @@ synonym: "amount of Rathke's pouch" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000758 ! Rathke's pouch quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005356 ! Rathke's pouch +intersection_of: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch [Term] id: OBA:0005537 @@ -153036,8 +252391,8 @@ def: "The morphology of a ureteric bud tip." [AUTO:patterns/patterns/entity_attr synonym: "morphology of ureteric bud tip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006364 ! ureteric bud tip -relationship: inheres_in UBERON:0006364 ! ureteric bud tip +intersection_of: RO:0000052 UBERON:0006364 ! inheres in ureteric bud tip +relationship: RO:0000052 UBERON:0006364 ! inheres in ureteric bud tip [Term] id: OBA:0005538 @@ -153046,8 +252401,8 @@ def: "The morphology of a ureteric bud trunk." [AUTO:patterns/patterns/entity_at synonym: "morphology of ureteric bud trunk" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012238 ! ureteric bud trunk -relationship: inheres_in UBERON:0012238 ! ureteric bud trunk +intersection_of: RO:0000052 UBERON:0012238 ! inheres in ureteric bud trunk +relationship: RO:0000052 UBERON:0012238 ! inheres in ureteric bud trunk [Term] id: OBA:0005539 @@ -153057,8 +252412,8 @@ synonym: "morphology of mucosa of urinary bladder" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001259 ! mucosa of urinary bladder -relationship: inheres_in UBERON:0001259 ! mucosa of urinary bladder +intersection_of: RO:0000052 UBERON:0001259 ! inheres in mucosa of urinary bladder +relationship: RO:0000052 UBERON:0001259 ! inheres in mucosa of urinary bladder [Term] id: OBA:0005540 @@ -153068,8 +252423,8 @@ synonym: "morphology of trigone of urinary bladder" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001257 ! trigone of urinary bladder -relationship: inheres_in UBERON:0001257 ! trigone of urinary bladder +intersection_of: RO:0000052 UBERON:0001257 ! inheres in trigone of urinary bladder +relationship: RO:0000052 UBERON:0001257 ! inheres in trigone of urinary bladder [Term] id: OBA:0005541 @@ -153079,8 +252434,8 @@ synonym: "morphology of undifferentiated genital tubercle" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005876 ! undifferentiated genital tubercle -relationship: inheres_in UBERON:0005876 ! undifferentiated genital tubercle +intersection_of: RO:0000052 UBERON:0005876 ! inheres in undifferentiated genital tubercle +relationship: RO:0000052 UBERON:0005876 ! inheres in undifferentiated genital tubercle [Term] id: OBA:0005542 @@ -153090,7 +252445,7 @@ synonym: "size of undifferentiated genital tubercle" EXACT [AUTO:patterns/patter is_a: OBA:0005541 ! undifferentiated genital tubercle morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005876 ! undifferentiated genital tubercle +intersection_of: RO:0000052 UBERON:0005876 ! inheres in undifferentiated genital tubercle [Term] id: OBA:0005543 @@ -153100,8 +252455,8 @@ synonym: "morphology of urinary bladder vasculature" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012239 ! urinary bladder vasculature -relationship: inheres_in UBERON:0012239 ! urinary bladder vasculature +intersection_of: RO:0000052 UBERON:0012239 ! inheres in urinary bladder vasculature +relationship: RO:0000052 UBERON:0012239 ! inheres in urinary bladder vasculature [Term] id: OBA:0005544 @@ -153110,8 +252465,8 @@ def: "The morphology of a urinary bladder detrusor smooth muscle." [AUTO:pattern synonym: "morphology of urinary bladder detrusor smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000381 ! urinary bladder detrusor smooth muscle -relationship: inheres_in UBERON:0000381 ! urinary bladder detrusor smooth muscle +intersection_of: RO:0000052 UBERON:0000381 ! inheres in urinary bladder detrusor smooth muscle +relationship: RO:0000052 UBERON:0000381 ! inheres in urinary bladder detrusor smooth muscle [Term] id: OBA:0005545 @@ -153121,7 +252476,7 @@ synonym: "structure of rectum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000492 ! rectum morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001052 ! rectum +intersection_of: RO:0000052 UBERON:0001052 ! inheres in rectum [Term] id: OBA:0005546 @@ -153130,8 +252485,8 @@ def: "The morphology of a male urethra." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of male urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000537 ! urethra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001333 ! male urethra -relationship: inheres_in UBERON:0001333 ! male urethra +intersection_of: RO:0000052 UBERON:0001333 ! inheres in male urethra +relationship: RO:0000052 UBERON:0001333 ! inheres in male urethra [Term] id: OBA:0005547 @@ -153141,8 +252496,8 @@ synonym: "morphology of prostatic urethra" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001335 ! prostatic urethra -relationship: inheres_in UBERON:0001335 ! prostatic urethra +intersection_of: RO:0000052 UBERON:0001335 ! inheres in prostatic urethra +relationship: RO:0000052 UBERON:0001335 ! inheres in prostatic urethra [Term] id: OBA:0005548 @@ -153152,8 +252507,8 @@ synonym: "morphology of male membranous urethra" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012302 ! male membranous urethra -relationship: inheres_in UBERON:0012302 ! male membranous urethra +intersection_of: RO:0000052 UBERON:0012302 ! inheres in male membranous urethra +relationship: RO:0000052 UBERON:0012302 ! inheres in male membranous urethra [Term] id: OBA:0005549 @@ -153163,8 +252518,8 @@ synonym: "morphology of spongiose part of urethra" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001337 ! spongiose part of urethra -relationship: inheres_in UBERON:0001337 ! spongiose part of urethra +intersection_of: RO:0000052 UBERON:0001337 ! inheres in spongiose part of urethra +relationship: RO:0000052 UBERON:0001337 ! inheres in spongiose part of urethra [Term] id: OBA:0005550 @@ -153173,8 +252528,8 @@ def: "The morphology of a female urethra." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of female urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000537 ! urethra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001334 ! female urethra -relationship: inheres_in UBERON:0001334 ! female urethra +intersection_of: RO:0000052 UBERON:0001334 ! inheres in female urethra +relationship: RO:0000052 UBERON:0001334 ! inheres in female urethra [Term] id: OBA:0005551 @@ -153184,8 +252539,8 @@ synonym: "functionality of bulbo-urethral gland" EXACT [AUTO:patterns/patterns/e is_a: OBA:0005811 ! male reproductive gland functionality is_a: OBA:0005998 ! mucous gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002366 ! bulbo-urethral gland -relationship: inheres_in UBERON:0002366 ! bulbo-urethral gland +intersection_of: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland +relationship: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland [Term] id: OBA:0005552 @@ -153195,8 +252550,8 @@ synonym: "morphology of internal urethral orifice" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012242 ! internal urethral orifice -relationship: inheres_in UBERON:0012242 ! internal urethral orifice +intersection_of: RO:0000052 UBERON:0012242 ! inheres in internal urethral orifice +relationship: RO:0000052 UBERON:0012242 ! inheres in internal urethral orifice [Term] id: OBA:0005553 @@ -153206,8 +252561,8 @@ synonym: "morphology of ureteral orifice" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012303 ! ureteral orifice -relationship: inheres_in UBERON:0012303 ! ureteral orifice +intersection_of: RO:0000052 UBERON:0012303 ! inheres in ureteral orifice +relationship: RO:0000052 UBERON:0012303 ! inheres in ureteral orifice [Term] id: OBA:0005554 @@ -153217,8 +252572,8 @@ synonym: "morphology of neck of urinary bladder" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001258 ! neck of urinary bladder -relationship: inheres_in UBERON:0001258 ! neck of urinary bladder +intersection_of: RO:0000052 UBERON:0001258 ! inheres in neck of urinary bladder +relationship: RO:0000052 UBERON:0001258 ! inheres in neck of urinary bladder [Term] id: OBA:0005555 @@ -153228,8 +252583,8 @@ synonym: "morphology of fundus of urinary bladder" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006082 ! fundus of urinary bladder -relationship: inheres_in UBERON:0006082 ! fundus of urinary bladder +intersection_of: RO:0000052 UBERON:0006082 ! inheres in fundus of urinary bladder +relationship: RO:0000052 UBERON:0006082 ! inheres in fundus of urinary bladder [Term] id: OBA:0005556 @@ -153239,8 +252594,8 @@ synonym: "morphology of major vestibular gland" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005808 ! female reproductive gland morphology is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000460 ! major vestibular gland -relationship: inheres_in UBERON:0000460 ! major vestibular gland +intersection_of: RO:0000052 UBERON:0000460 ! inheres in major vestibular gland +relationship: RO:0000052 UBERON:0000460 ! inheres in major vestibular gland [Term] id: OBA:0005557 @@ -153250,8 +252605,8 @@ synonym: "amount of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000057 ! urethra -relationship: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra +relationship: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:0005558 @@ -153260,8 +252615,8 @@ def: "The morphology of a urethral gland." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of urethral gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001338 ! urethral gland -relationship: inheres_in UBERON:0001338 ! urethral gland +intersection_of: RO:0000052 UBERON:0001338 ! inheres in urethral gland +relationship: RO:0000052 UBERON:0001338 ! inheres in urethral gland [Term] id: OBA:0005559 @@ -153270,8 +252625,8 @@ def: "The morphology of a paraurethral gland." [AUTO:patterns/patterns/entity_at synonym: "morphology of paraurethral gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005808 ! female reproductive gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010145 ! paraurethral gland -relationship: inheres_in UBERON:0010145 ! paraurethral gland +intersection_of: RO:0000052 UBERON:0010145 ! inheres in paraurethral gland +relationship: RO:0000052 UBERON:0010145 ! inheres in paraurethral gland [Term] id: OBA:0005560 @@ -153280,8 +252635,8 @@ def: "The morphology of a male urethral gland." [AUTO:patterns/patterns/entity_a synonym: "morphology of male urethral gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005558 ! urethral gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010186 ! male urethral gland -relationship: inheres_in UBERON:0010186 ! male urethral gland +intersection_of: RO:0000052 UBERON:0010186 ! inheres in male urethral gland +relationship: RO:0000052 UBERON:0010186 ! inheres in male urethral gland [Term] id: OBA:0005561 @@ -153291,8 +252646,8 @@ synonym: "morphology of urethral meatus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012240 ! urethral meatus -relationship: inheres_in UBERON:0012240 ! urethral meatus +intersection_of: RO:0000052 UBERON:0012240 ! inheres in urethral meatus +relationship: RO:0000052 UBERON:0012240 ! inheres in urethral meatus [Term] id: OBA:0005562 @@ -153302,8 +252657,8 @@ synonym: "mass of urinary bladder" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001255 ! urinary bladder -relationship: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder +relationship: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:0005563 @@ -153313,8 +252668,8 @@ synonym: "rate of cell migration" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0016477 ! cell migration -relationship: inheres_in GO:0016477 ! cell migration +intersection_of: RO:0000052 GO:0016477 ! inheres in cell migration +relationship: RO:0000052 GO:0016477 ! inheres in cell migration [Term] id: OBA:0005564 @@ -153324,7 +252679,7 @@ synonym: "length of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010613 ! cranium size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:0005565 @@ -153333,8 +252688,8 @@ def: "The morphology of a Fraction A pre-pro B cell." [AUTO:patterns/patterns/en synonym: "morphology of Fraction A pre-pro B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005432 ! pro-B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002045 ! Fraction A pre-pro B cell -relationship: inheres_in CL:0002045 ! Fraction A pre-pro B cell +intersection_of: RO:0000052 CL:0002045 ! inheres in Fraction A pre-pro B cell +relationship: RO:0000052 CL:0002045 ! inheres in Fraction A pre-pro B cell [Term] id: OBA:0005566 @@ -153343,8 +252698,8 @@ def: "The rate of a type B pancreatic cell proliferation." [AUTO:patterns/patter synonym: "rate of type B pancreatic cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0044342 ! type B pancreatic cell proliferation -relationship: inheres_in GO:0044342 ! type B pancreatic cell proliferation +intersection_of: RO:0000052 GO:0044342 ! inheres in type B pancreatic cell proliferation +relationship: RO:0000052 GO:0044342 ! inheres in type B pancreatic cell proliferation [Term] id: OBA:0005567 @@ -153353,8 +252708,8 @@ def: "The rate of a cell chemotaxis." [AUTO:patterns/patterns/entity_attribute] synonym: "rate of cell chemotaxis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005563 ! cell migration rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060326 ! cell chemotaxis -relationship: inheres_in GO:0060326 ! cell chemotaxis +intersection_of: RO:0000052 GO:0060326 ! inheres in cell chemotaxis +relationship: RO:0000052 GO:0060326 ! inheres in cell chemotaxis [Term] id: OBA:0005568 @@ -153364,8 +252719,8 @@ synonym: "rate of lymphocyte chemotaxis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005567 ! cell chemotaxis rate is_a: OBA:VT0003156 ! leukocyte migration trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0048247 ! lymphocyte chemotaxis -relationship: inheres_in GO:0048247 ! lymphocyte chemotaxis +intersection_of: RO:0000052 GO:0048247 ! inheres in lymphocyte chemotaxis +relationship: RO:0000052 GO:0048247 ! inheres in lymphocyte chemotaxis [Term] id: OBA:0005569 @@ -153375,8 +252730,8 @@ synonym: "occurrence of neuron differentiation" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence -intersection_of: inheres_in GO:0030182 ! neuron differentiation -relationship: inheres_in GO:0030182 ! neuron differentiation +intersection_of: RO:0000052 GO:0030182 ! inheres in neuron differentiation +relationship: RO:0000052 GO:0030182 ! inheres in neuron differentiation [Term] id: OBA:0005570 @@ -153386,7 +252741,7 @@ synonym: "structure of urinary bladder" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000538 ! urinary bladder morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:0005571 @@ -153395,8 +252750,8 @@ def: "The morphology of a cremaster muscle." [AUTO:patterns/patterns/entity_attr synonym: "morphology of cremaster muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008488 ! cremaster muscle -relationship: inheres_in UBERON:0008488 ! cremaster muscle +intersection_of: RO:0000052 UBERON:0008488 ! inheres in cremaster muscle +relationship: RO:0000052 UBERON:0008488 ! inheres in cremaster muscle [Term] id: OBA:0005572 @@ -153406,8 +252761,8 @@ synonym: "morphology of female preputial gland" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005808 ! female reproductive gland morphology is_a: OBA:VT0002717 ! preputial gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005302 ! female preputial gland -relationship: inheres_in UBERON:0005302 ! female preputial gland +intersection_of: RO:0000052 UBERON:0005302 ! inheres in female preputial gland +relationship: RO:0000052 UBERON:0005302 ! inheres in female preputial gland [Term] id: OBA:0005573 @@ -153417,8 +252772,8 @@ synonym: "morphology of urogenital fold" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004876 ! urogenital fold -relationship: inheres_in UBERON:0004876 ! urogenital fold +intersection_of: RO:0000052 UBERON:0004876 ! inheres in urogenital fold +relationship: RO:0000052 UBERON:0004876 ! inheres in urogenital fold [Term] id: OBA:0005574 @@ -153428,8 +252783,8 @@ synonym: "morphology of cloacal membrane" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006217 ! cloacal membrane -relationship: inheres_in UBERON:0006217 ! cloacal membrane +intersection_of: RO:0000052 UBERON:0006217 ! inheres in cloacal membrane +relationship: RO:0000052 UBERON:0006217 ! inheres in cloacal membrane [Term] id: OBA:0005575 @@ -153439,8 +252794,8 @@ synonym: "morphology of navicular fossa of spongiose part of urethra" EXACT [AUT is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012294 ! navicular fossa of spongiose part of urethra -relationship: inheres_in UBERON:0012294 ! navicular fossa of spongiose part of urethra +intersection_of: RO:0000052 UBERON:0012294 ! inheres in navicular fossa of spongiose part of urethra +relationship: RO:0000052 UBERON:0012294 ! inheres in navicular fossa of spongiose part of urethra [Term] id: OBA:0005576 @@ -153450,8 +252805,8 @@ synonym: "morphology of Guérin's valve" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012295 ! Guérin's valve -relationship: inheres_in UBERON:0012295 ! Guérin's valve +intersection_of: RO:0000052 UBERON:0012295 ! inheres in Guérin's valve +relationship: RO:0000052 UBERON:0012295 ! inheres in Guérin's valve [Term] id: OBA:0005577 @@ -153461,8 +252816,8 @@ synonym: "morphology of urethral crest" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012296 ! urethral crest -relationship: inheres_in UBERON:0012296 ! urethral crest +intersection_of: RO:0000052 UBERON:0012296 ! inheres in urethral crest +relationship: RO:0000052 UBERON:0012296 ! inheres in urethral crest [Term] id: OBA:0005578 @@ -153471,8 +252826,8 @@ def: "The morphology of a male urethral crest." [AUTO:patterns/patterns/entity_a synonym: "morphology of male urethral crest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005577 ! urethral crest morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012297 ! male urethral crest -relationship: inheres_in UBERON:0012297 ! male urethral crest +intersection_of: RO:0000052 UBERON:0012297 ! inheres in male urethral crest +relationship: RO:0000052 UBERON:0012297 ! inheres in male urethral crest [Term] id: OBA:0005579 @@ -153481,8 +252836,8 @@ def: "The morphology of a female urethral crest." [AUTO:patterns/patterns/entity synonym: "morphology of female urethral crest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005577 ! urethral crest morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012298 ! female urethral crest -relationship: inheres_in UBERON:0012298 ! female urethral crest +intersection_of: RO:0000052 UBERON:0012298 ! inheres in female urethral crest +relationship: RO:0000052 UBERON:0012298 ! inheres in female urethral crest [Term] id: OBA:0005580 @@ -153491,8 +252846,8 @@ def: "The morphology of a kidney collecting duct epithelium." [AUTO:patterns/pat synonym: "morphology of kidney collecting duct epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014388 ! kidney collecting duct epithelium -relationship: inheres_in UBERON:0014388 ! kidney collecting duct epithelium +intersection_of: RO:0000052 UBERON:0014388 ! inheres in kidney collecting duct epithelium +relationship: RO:0000052 UBERON:0014388 ! inheres in kidney collecting duct epithelium [Term] id: OBA:0005581 @@ -153501,8 +252856,8 @@ def: "The morphology of a vestibule of vagina." [AUTO:patterns/patterns/entity_a synonym: "morphology of vestibule of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000034 ! vestibule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008330 ! vestibule of vagina -relationship: inheres_in UBERON:0008330 ! vestibule of vagina +intersection_of: RO:0000052 UBERON:0008330 ! inheres in vestibule of vagina +relationship: RO:0000052 UBERON:0008330 ! inheres in vestibule of vagina [Term] id: OBA:0005582 @@ -153511,8 +252866,8 @@ def: "The morphology of a os clitoris." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of os clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0006101 ! bone of reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006440 ! os clitoris -relationship: inheres_in UBERON:0006440 ! os clitoris +intersection_of: RO:0000052 UBERON:0006440 ! inheres in os clitoris +relationship: RO:0000052 UBERON:0006440 ! inheres in os clitoris [Term] id: OBA:0005583 @@ -153522,8 +252877,8 @@ synonym: "amount of os clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006440 ! os clitoris -relationship: inheres_in UBERON:0006440 ! os clitoris +intersection_of: RO:0000052 UBERON:0006440 ! inheres in os clitoris +relationship: RO:0000052 UBERON:0006440 ! inheres in os clitoris [Term] id: OBA:0005584 @@ -153533,8 +252888,8 @@ synonym: "morphology of urorectal septum" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005760 ! urorectal septum -relationship: inheres_in UBERON:0005760 ! urorectal septum +intersection_of: RO:0000052 UBERON:0005760 ! inheres in urorectal septum +relationship: RO:0000052 UBERON:0005760 ! inheres in urorectal septum [Term] id: OBA:0005585 @@ -153544,8 +252899,8 @@ synonym: "amount of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000945 ! stomach -relationship: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach +relationship: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:0005586 @@ -153555,7 +252910,7 @@ synonym: "altered number of of diaphragm" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0002279 ! diaphragm morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:0005587 @@ -153565,8 +252920,8 @@ synonym: "amount of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001155 ! colon -relationship: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon +relationship: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:0005588 @@ -153575,8 +252930,8 @@ def: "The rate of a hematopoietic stem cell proliferation." [AUTO:patterns/patte synonym: "rate of hematopoietic stem cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0071425 ! hematopoietic stem cell proliferation -relationship: inheres_in GO:0071425 ! hematopoietic stem cell proliferation +intersection_of: RO:0000052 GO:0071425 ! inheres in hematopoietic stem cell proliferation +relationship: RO:0000052 GO:0071425 ! inheres in hematopoietic stem cell proliferation [Term] id: OBA:0005589 @@ -153585,8 +252940,8 @@ def: "The rate of a Schwann cell proliferation." [AUTO:patterns/patterns/entity_ synonym: "rate of Schwann cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0014010 ! Schwann cell proliferation -relationship: inheres_in GO:0014010 ! Schwann cell proliferation +intersection_of: RO:0000052 GO:0014010 ! inheres in Schwann cell proliferation +relationship: RO:0000052 GO:0014010 ! inheres in Schwann cell proliferation [Term] id: OBA:0005590 @@ -153596,8 +252951,8 @@ synonym: "morphology of zona intermedia of adrenal gland" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013745 ! zona intermedia of adrenal gland -relationship: inheres_in UBERON:0013745 ! zona intermedia of adrenal gland +intersection_of: RO:0000052 UBERON:0013745 ! inheres in zona intermedia of adrenal gland +relationship: RO:0000052 UBERON:0013745 ! inheres in zona intermedia of adrenal gland [Term] id: OBA:0005591 @@ -153607,7 +252962,7 @@ synonym: "structure of intestine" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000477 ! intestine morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:0005592 @@ -153617,8 +252972,8 @@ synonym: "rate of macrophage proliferation" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003479 ! cell population proliferation rate is_a: OBA:VT0010417 ! leukocyte proliferation trait intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0061517 ! macrophage proliferation -relationship: inheres_in GO:0061517 ! macrophage proliferation +intersection_of: RO:0000052 GO:0061517 ! inheres in macrophage proliferation +relationship: RO:0000052 GO:0061517 ! inheres in macrophage proliferation [Term] id: OBA:0005593 @@ -153628,8 +252983,8 @@ synonym: "morphology of septum of telencephalon" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000446 ! septum of telencephalon -relationship: inheres_in UBERON:0000446 ! septum of telencephalon +intersection_of: RO:0000052 UBERON:0000446 ! inheres in septum of telencephalon +relationship: RO:0000052 UBERON:0000446 ! inheres in septum of telencephalon [Term] id: OBA:0005594 @@ -153639,8 +252994,8 @@ synonym: "morphology of septum pellucidum" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004714 ! septum pellucidum -relationship: inheres_in UBERON:0004714 ! septum pellucidum +intersection_of: RO:0000052 UBERON:0004714 ! inheres in septum pellucidum +relationship: RO:0000052 UBERON:0004714 ! inheres in septum pellucidum [Term] id: OBA:0005595 @@ -153650,8 +253005,8 @@ synonym: "functionality of olfactory epithelium" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001997 ! olfactory epithelium -relationship: inheres_in UBERON:0001997 ! olfactory epithelium +intersection_of: RO:0000052 UBERON:0001997 ! inheres in olfactory epithelium +relationship: RO:0000052 UBERON:0001997 ! inheres in olfactory epithelium [Term] id: OBA:0005596 @@ -153661,8 +253016,8 @@ synonym: "morphology of comma-shaped body" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004198 ! comma-shaped body -relationship: inheres_in UBERON:0004198 ! comma-shaped body +intersection_of: RO:0000052 UBERON:0004198 ! inheres in comma-shaped body +relationship: RO:0000052 UBERON:0004198 ! inheres in comma-shaped body [Term] id: OBA:0005597 @@ -153672,8 +253027,8 @@ synonym: "morphology of S-shaped body" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004199 ! S-shaped body -relationship: inheres_in UBERON:0004199 ! S-shaped body +intersection_of: RO:0000052 UBERON:0004199 ! inheres in S-shaped body +relationship: RO:0000052 UBERON:0004199 ! inheres in S-shaped body [Term] id: OBA:0005598 @@ -153682,8 +253037,8 @@ def: "The morphology of a morula." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of morula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001076 ! embryo morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000085 ! morula -relationship: inheres_in UBERON:0000085 ! morula +intersection_of: RO:0000052 UBERON:0000085 ! inheres in morula +relationship: RO:0000052 UBERON:0000085 ! inheres in morula [Term] id: OBA:0005599 @@ -153692,8 +253047,8 @@ def: "The morphology of a central tendon of diaphragm." [AUTO:patterns/patterns/ synonym: "morphology of central tendon of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005503 ! tendon morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006670 ! central tendon of diaphragm -relationship: inheres_in UBERON:0006670 ! central tendon of diaphragm +intersection_of: RO:0000052 UBERON:0006670 ! inheres in central tendon of diaphragm +relationship: RO:0000052 UBERON:0006670 ! inheres in central tendon of diaphragm [Term] id: OBA:0005600 @@ -153703,7 +253058,7 @@ synonym: "amount of astrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000381 ! astrocyte quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000127 ! astrocyte +intersection_of: RO:0000052 CL:0000127 ! inheres in astrocyte [Term] id: OBA:0005601 @@ -153713,7 +253068,7 @@ synonym: "altered number of of astrocyte" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0002182 ! astrocyte morphology trait is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of -intersection_of: inheres_in CL:0000127 ! astrocyte +intersection_of: RO:0000052 CL:0000127 ! inheres in astrocyte [Term] id: OBA:0005602 @@ -153722,8 +253077,8 @@ def: "The morphology of a olfactory gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of olfactory gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005878 ! gland of nasal mucosa morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002232 ! olfactory gland -relationship: inheres_in UBERON:0002232 ! olfactory gland +intersection_of: RO:0000052 UBERON:0002232 ! inheres in olfactory gland +relationship: RO:0000052 UBERON:0002232 ! inheres in olfactory gland [Term] id: OBA:0005603 @@ -153732,8 +253087,8 @@ def: "The morphology of a globose cell of olfactory epithelium." [AUTO:patterns/ synonym: "morphology of globose cell of olfactory epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002171 ! globose cell of olfactory epithelium -relationship: inheres_in CL:0002171 ! globose cell of olfactory epithelium +intersection_of: RO:0000052 CL:0002171 ! inheres in globose cell of olfactory epithelium +relationship: RO:0000052 CL:0002171 ! inheres in globose cell of olfactory epithelium [Term] id: OBA:0005604 @@ -153742,8 +253097,8 @@ def: "The morphology of a basal proper cell of olfactory epithelium." [AUTO:patt synonym: "morphology of basal proper cell of olfactory epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002184 ! basal proper cell of olfactory epithelium -relationship: inheres_in CL:0002184 ! basal proper cell of olfactory epithelium +intersection_of: RO:0000052 CL:0002184 ! inheres in basal proper cell of olfactory epithelium +relationship: RO:0000052 CL:0002184 ! inheres in basal proper cell of olfactory epithelium [Term] id: OBA:0005605 @@ -153753,7 +253108,7 @@ synonym: "onset quality of heart development" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0000267 ! heart development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007507 ! heart development +intersection_of: RO:0000052 GO:0007507 ! inheres in heart development [Term] id: OBA:0005606 @@ -153763,8 +253118,8 @@ synonym: "amount of foregut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001041 ! foregut -relationship: inheres_in UBERON:0001041 ! foregut +intersection_of: RO:0000052 UBERON:0001041 ! inheres in foregut +relationship: RO:0000052 UBERON:0001041 ! inheres in foregut [Term] id: OBA:0005607 @@ -153774,8 +253129,8 @@ synonym: "amount of hindgut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001046 ! hindgut -relationship: inheres_in UBERON:0001046 ! hindgut +intersection_of: RO:0000052 UBERON:0001046 ! inheres in hindgut +relationship: RO:0000052 UBERON:0001046 ! inheres in hindgut [Term] id: OBA:0005608 @@ -153785,8 +253140,8 @@ synonym: "amount of trophectoderm" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004345 ! trophectoderm -relationship: inheres_in UBERON:0004345 ! trophectoderm +intersection_of: RO:0000052 UBERON:0004345 ! inheres in trophectoderm +relationship: RO:0000052 UBERON:0004345 ! inheres in trophectoderm [Term] id: OBA:0005609 @@ -153796,8 +253151,8 @@ synonym: "morphology of bilaminar disc" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000091 ! bilaminar disc -relationship: inheres_in UBERON:0000091 ! bilaminar disc +intersection_of: RO:0000052 UBERON:0000091 ! inheres in bilaminar disc +relationship: RO:0000052 UBERON:0000091 ! inheres in bilaminar disc [Term] id: OBA:0005610 @@ -153807,7 +253162,7 @@ synonym: "onset quality of gastrulation" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0001695 ! gastrulation trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007369 ! gastrulation +intersection_of: RO:0000052 GO:0007369 ! inheres in gastrulation [Term] id: OBA:0005611 @@ -153816,8 +253171,8 @@ def: "The rate of a inner cell mass cell proliferation." [AUTO:patterns/patterns synonym: "rate of inner cell mass cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001833 ! inner cell mass cell proliferation -relationship: inheres_in GO:0001833 ! inner cell mass cell proliferation +intersection_of: RO:0000052 GO:0001833 ! inheres in inner cell mass cell proliferation +relationship: RO:0000052 GO:0001833 ! inheres in inner cell mass cell proliferation [Term] id: OBA:0005612 @@ -153827,8 +253182,8 @@ synonym: "amount of inner cell mass cell proliferation" EXACT [AUTO:patterns/pat is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001833 ! inner cell mass cell proliferation -relationship: inheres_in GO:0001833 ! inner cell mass cell proliferation +intersection_of: RO:0000052 GO:0001833 ! inheres in inner cell mass cell proliferation +relationship: RO:0000052 GO:0001833 ! inheres in inner cell mass cell proliferation [Term] id: OBA:0005613 @@ -153837,8 +253192,8 @@ def: "The rate of a trophectodermal cell proliferation." [AUTO:patterns/patterns synonym: "rate of trophectodermal cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001834 ! trophectodermal cell proliferation -relationship: inheres_in GO:0001834 ! trophectodermal cell proliferation +intersection_of: RO:0000052 GO:0001834 ! inheres in trophectodermal cell proliferation +relationship: RO:0000052 GO:0001834 ! inheres in trophectodermal cell proliferation [Term] id: OBA:0005614 @@ -153848,8 +253203,8 @@ synonym: "amount of trophectodermal cell proliferation" EXACT [AUTO:patterns/pat is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001834 ! trophectodermal cell proliferation -relationship: inheres_in GO:0001834 ! trophectodermal cell proliferation +intersection_of: RO:0000052 GO:0001834 ! inheres in trophectodermal cell proliferation +relationship: RO:0000052 GO:0001834 ! inheres in trophectodermal cell proliferation [Term] id: OBA:0005615 @@ -153859,8 +253214,8 @@ synonym: "morphology of midbrain-hindbrain boundary" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003052 ! midbrain-hindbrain boundary -relationship: inheres_in UBERON:0003052 ! midbrain-hindbrain boundary +intersection_of: RO:0000052 UBERON:0003052 ! inheres in midbrain-hindbrain boundary +relationship: RO:0000052 UBERON:0003052 ! inheres in midbrain-hindbrain boundary [Term] id: OBA:0005616 @@ -153870,8 +253225,8 @@ synonym: "amount of forebrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001890 ! forebrain -relationship: inheres_in UBERON:0001890 ! forebrain +intersection_of: RO:0000052 UBERON:0001890 ! inheres in forebrain +relationship: RO:0000052 UBERON:0001890 ! inheres in forebrain [Term] id: OBA:0005617 @@ -153881,8 +253236,8 @@ synonym: "amount of visceral endoderm" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004877 ! visceral endoderm -relationship: inheres_in UBERON:0004877 ! visceral endoderm +intersection_of: RO:0000052 UBERON:0004877 ! inheres in visceral endoderm +relationship: RO:0000052 UBERON:0004877 ! inheres in visceral endoderm [Term] id: OBA:0005618 @@ -153891,8 +253246,8 @@ def: "The amount of a anterior visceral endoderm." [AUTO:patterns/patterns/entit synonym: "amount of anterior visceral endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005617 ! visceral endoderm amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004044 ! anterior visceral endoderm -relationship: inheres_in UBERON:0004044 ! anterior visceral endoderm +intersection_of: RO:0000052 UBERON:0004044 ! inheres in anterior visceral endoderm +relationship: RO:0000052 UBERON:0004044 ! inheres in anterior visceral endoderm [Term] id: OBA:0005619 @@ -153902,8 +253257,8 @@ synonym: "amount of parietal endoderm" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008800 ! parietal endoderm -relationship: inheres_in UBERON:0008800 ! parietal endoderm +intersection_of: RO:0000052 UBERON:0008800 ! inheres in parietal endoderm +relationship: RO:0000052 UBERON:0008800 ! inheres in parietal endoderm [Term] id: OBA:0005620 @@ -153913,8 +253268,8 @@ synonym: "morphology of lens placode" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003073 ! lens placode -relationship: inheres_in UBERON:0003073 ! lens placode +intersection_of: RO:0000052 UBERON:0003073 ! inheres in lens placode +relationship: RO:0000052 UBERON:0003073 ! inheres in lens placode [Term] id: OBA:0005621 @@ -153924,7 +253279,7 @@ synonym: "composition of amniotic fluid" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000263 ! amniotic fluid quality is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000173 ! amniotic fluid +intersection_of: RO:0000052 UBERON:0000173 ! inheres in amniotic fluid [Term] id: OBA:0005622 @@ -153934,7 +253289,7 @@ synonym: "onset quality of head development" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0015047 ! head development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060322 ! head development +intersection_of: RO:0000052 GO:0060322 ! inheres in head development [Term] id: OBA:0005623 @@ -153944,8 +253299,8 @@ synonym: "morphology of presomitic mesoderm" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003059 ! presomitic mesoderm -relationship: inheres_in UBERON:0003059 ! presomitic mesoderm +intersection_of: RO:0000052 UBERON:0003059 ! inheres in presomitic mesoderm +relationship: RO:0000052 UBERON:0003059 ! inheres in presomitic mesoderm [Term] id: OBA:0005624 @@ -153954,8 +253309,8 @@ def: "The morphology of a muscle precursor cell." [AUTO:patterns/patterns/entity synonym: "morphology of muscle precursor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000680 ! muscle precursor cell -relationship: inheres_in CL:0000680 ! muscle precursor cell +intersection_of: RO:0000052 CL:0000680 ! inheres in muscle precursor cell +relationship: RO:0000052 CL:0000680 ! inheres in muscle precursor cell [Term] id: OBA:0005625 @@ -153965,8 +253320,8 @@ synonym: "morphology of intraembryonic coelom" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003887 ! intraembryonic coelom -relationship: inheres_in UBERON:0003887 ! intraembryonic coelom +intersection_of: RO:0000052 UBERON:0003887 ! inheres in intraembryonic coelom +relationship: RO:0000052 UBERON:0003887 ! inheres in intraembryonic coelom [Term] id: OBA:0005626 @@ -153975,8 +253330,8 @@ def: "The rate of a keratinocyte migration." [AUTO:patterns/patterns/entity_attr synonym: "rate of keratinocyte migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005563 ! cell migration rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0051546 ! keratinocyte migration -relationship: inheres_in GO:0051546 ! keratinocyte migration +intersection_of: RO:0000052 GO:0051546 ! inheres in keratinocyte migration +relationship: RO:0000052 GO:0051546 ! inheres in keratinocyte migration [Term] id: OBA:0005627 @@ -153986,8 +253341,8 @@ synonym: "rate of myofibroblast differentiation" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0036446 ! myofibroblast differentiation -relationship: inheres_in GO:0036446 ! myofibroblast differentiation +intersection_of: RO:0000052 GO:0036446 ! inheres in myofibroblast differentiation +relationship: RO:0000052 GO:0036446 ! inheres in myofibroblast differentiation [Term] id: OBA:0005628 @@ -153996,8 +253351,8 @@ def: "The rate of a endothelial cell proliferation." [AUTO:patterns/patterns/ent synonym: "rate of endothelial cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001935 ! endothelial cell proliferation -relationship: inheres_in GO:0001935 ! endothelial cell proliferation +intersection_of: RO:0000052 GO:0001935 ! inheres in endothelial cell proliferation +relationship: RO:0000052 GO:0001935 ! inheres in endothelial cell proliferation [Term] id: OBA:0005629 @@ -154006,8 +253361,8 @@ def: "The morphology of a neuronal stem cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of neuronal stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002400 ! multipotent stem cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000047 ! neuronal stem cell -relationship: inheres_in CL:0000047 ! neuronal stem cell +intersection_of: RO:0000052 CL:0000047 ! inheres in neuronal stem cell +relationship: RO:0000052 CL:0000047 ! inheres in neuronal stem cell [Term] id: OBA:0005630 @@ -154016,8 +253371,8 @@ def: "The morphology of a hepatic diverticulum." [AUTO:patterns/patterns/entity_ synonym: "morphology of hepatic diverticulum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008835 ! hepatic diverticulum -relationship: inheres_in UBERON:0008835 ! hepatic diverticulum +intersection_of: RO:0000052 UBERON:0008835 ! inheres in hepatic diverticulum +relationship: RO:0000052 UBERON:0008835 ! inheres in hepatic diverticulum [Term] id: OBA:0005631 @@ -154026,8 +253381,8 @@ def: "The morphology of a liver primordium." [AUTO:patterns/patterns/entity_attr synonym: "morphology of liver primordium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003894 ! liver primordium -relationship: inheres_in UBERON:0003894 ! liver primordium +intersection_of: RO:0000052 UBERON:0003894 ! inheres in liver primordium +relationship: RO:0000052 UBERON:0003894 ! inheres in liver primordium [Term] id: OBA:0005632 @@ -154036,8 +253391,8 @@ def: "The morphology of a cholangiocyte." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of cholangiocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000488 ! cholangiocyte -relationship: inheres_in CL:1000488 ! cholangiocyte +intersection_of: RO:0000052 CL:1000488 ! inheres in cholangiocyte +relationship: RO:0000052 CL:1000488 ! inheres in cholangiocyte [Term] id: OBA:0005633 @@ -154046,8 +253401,8 @@ def: "The morphology of a hepatoblast." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of hepatoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002400 ! multipotent stem cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0005026 ! hepatoblast -relationship: inheres_in CL:0005026 ! hepatoblast +intersection_of: RO:0000052 CL:0005026 ! inheres in hepatoblast +relationship: RO:0000052 CL:0005026 ! inheres in hepatoblast [Term] id: OBA:0005634 @@ -154057,8 +253412,8 @@ synonym: "amount of hepatoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0005026 ! hepatoblast -relationship: inheres_in CL:0005026 ! hepatoblast +intersection_of: RO:0000052 CL:0005026 ! inheres in hepatoblast +relationship: RO:0000052 CL:0005026 ! inheres in hepatoblast [Term] id: OBA:0005635 @@ -154068,8 +253423,8 @@ synonym: "morphology of hepatic cord" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005452 ! hepatic cord -relationship: inheres_in UBERON:0005452 ! hepatic cord +intersection_of: RO:0000052 UBERON:0005452 ! inheres in hepatic cord +relationship: RO:0000052 UBERON:0005452 ! inheres in hepatic cord [Term] id: OBA:0005636 @@ -154078,8 +253433,8 @@ def: "The morphology of a septum transversum." [AUTO:patterns/patterns/entity_at synonym: "morphology of septum transversum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004161 ! septum transversum -relationship: inheres_in UBERON:0004161 ! septum transversum +intersection_of: RO:0000052 UBERON:0004161 ! inheres in septum transversum +relationship: RO:0000052 UBERON:0004161 ! inheres in septum transversum [Term] id: OBA:0005637 @@ -154088,8 +253443,8 @@ def: "The morphology of a intersomitic vessel." [AUTO:patterns/patterns/entity_a synonym: "morphology of intersomitic vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014907 ! intersomitic vessel -relationship: inheres_in UBERON:0014907 ! intersomitic vessel +intersection_of: RO:0000052 UBERON:0014907 ! inheres in intersomitic vessel +relationship: RO:0000052 UBERON:0014907 ! inheres in intersomitic vessel [Term] id: OBA:0005638 @@ -154099,8 +253454,8 @@ synonym: "morphology of intersomitic vein" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005637 ! intersomitic vessel morphology is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007679 ! intersomitic vein -relationship: inheres_in UBERON:0007679 ! intersomitic vein +intersection_of: RO:0000052 UBERON:0007679 ! inheres in intersomitic vein +relationship: RO:0000052 UBERON:0007679 ! inheres in intersomitic vein [Term] id: OBA:0005639 @@ -154110,7 +253465,7 @@ synonym: "morphology of philtrum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000163 ! philtrum quality is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum [Term] id: OBA:0005640 @@ -154120,7 +253475,7 @@ synonym: "amount of philtrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000163 ! philtrum quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum [Term] id: OBA:0005641 @@ -154130,7 +253485,7 @@ synonym: "size of hindbrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000841 ! hindbrain morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002028 ! hindbrain +intersection_of: RO:0000052 UBERON:0002028 ! inheres in hindbrain [Term] id: OBA:0005642 @@ -154140,8 +253495,8 @@ synonym: "morphology of red nucleus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001947 ! red nucleus -relationship: inheres_in UBERON:0001947 ! red nucleus +intersection_of: RO:0000052 UBERON:0001947 ! inheres in red nucleus +relationship: RO:0000052 UBERON:0001947 ! inheres in red nucleus [Term] id: OBA:0005643 @@ -154151,8 +253506,8 @@ synonym: "morphology of chordamesoderm" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004880 ! chordamesoderm -relationship: inheres_in UBERON:0004880 ! chordamesoderm +intersection_of: RO:0000052 UBERON:0004880 ! inheres in chordamesoderm +relationship: RO:0000052 UBERON:0004880 ! inheres in chordamesoderm [Term] id: OBA:0005644 @@ -154161,8 +253516,8 @@ def: "The morphology of a cardiogenic splanchnic mesoderm." [AUTO:patterns/patte synonym: "morphology of cardiogenic splanchnic mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007005 ! cardiogenic splanchnic mesoderm -relationship: inheres_in UBERON:0007005 ! cardiogenic splanchnic mesoderm +intersection_of: RO:0000052 UBERON:0007005 ! inheres in cardiogenic splanchnic mesoderm +relationship: RO:0000052 UBERON:0007005 ! inheres in cardiogenic splanchnic mesoderm [Term] id: OBA:0005645 @@ -154172,7 +253527,7 @@ synonym: "morphology of umbilical blood vessel" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000414 ! umbilical blood vessel quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010260 ! umbilical blood vessel +intersection_of: RO:0000052 UBERON:0010260 ! inheres in umbilical blood vessel [Term] id: OBA:0005646 @@ -154183,7 +253538,7 @@ is_a: OBA:0003389 ! artery structure is_a: OBA:0005645 ! umbilical blood vessel morphology is_a: OBA:1000745 ! umbilical artery quality intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001310 ! umbilical artery +intersection_of: RO:0000052 UBERON:0001310 ! inheres in umbilical artery [Term] id: OBA:0005647 @@ -154193,7 +253548,7 @@ synonym: "structure of umbilical vein" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003463 ! blood vessel structure is_a: OBA:0005144 ! umbilical vein morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002066 ! umbilical vein +intersection_of: RO:0000052 UBERON:0002066 ! inheres in umbilical vein [Term] id: OBA:0005648 @@ -154202,8 +253557,8 @@ def: "The morphology of a carotid duct." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of carotid duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010198 ! carotid duct -relationship: inheres_in UBERON:0010198 ! carotid duct +intersection_of: RO:0000052 UBERON:0010198 ! inheres in carotid duct +relationship: RO:0000052 UBERON:0010198 ! inheres in carotid duct [Term] id: OBA:0005649 @@ -154212,8 +253567,8 @@ def: "The morphology of a nail bed." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of nail bed" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005273 ! nail bed -relationship: inheres_in UBERON:0005273 ! nail bed +intersection_of: RO:0000052 UBERON:0005273 ! inheres in nail bed +relationship: RO:0000052 UBERON:0005273 ! inheres in nail bed [Term] id: OBA:0005650 @@ -154223,7 +253578,7 @@ synonym: "size of primary motor cortex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000800 ! prefrontal gyrus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001384 ! primary motor cortex +intersection_of: RO:0000052 UBERON:0001384 ! inheres in primary motor cortex [Term] id: OBA:0005651 @@ -154233,8 +253588,8 @@ synonym: "morphology of retrosplenial granular cortex" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014918 ! retrosplenial granular cortex -relationship: inheres_in UBERON:0014918 ! retrosplenial granular cortex +intersection_of: RO:0000052 UBERON:0014918 ! inheres in retrosplenial granular cortex +relationship: RO:0000052 UBERON:0014918 ! inheres in retrosplenial granular cortex [Term] id: OBA:0005652 @@ -154244,7 +253599,7 @@ synonym: "size of retrosplenial granular cortex" EXACT [AUTO:patterns/patterns/e is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005651 ! retrosplenial granular cortex morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014918 ! retrosplenial granular cortex +intersection_of: RO:0000052 UBERON:0014918 ! inheres in retrosplenial granular cortex [Term] id: OBA:0005653 @@ -154253,8 +253608,8 @@ def: "The morphology of a mammillothalamic tract of hypothalamus." [AUTO:pattern synonym: "morphology of mammillothalamic tract of hypothalamus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002990 ! mammillothalamic tract of hypothalamus -relationship: inheres_in UBERON:0002990 ! mammillothalamic tract of hypothalamus +intersection_of: RO:0000052 UBERON:0002990 ! inheres in mammillothalamic tract of hypothalamus +relationship: RO:0000052 UBERON:0002990 ! inheres in mammillothalamic tract of hypothalamus [Term] id: OBA:0005654 @@ -154264,7 +253619,7 @@ synonym: "size of mammillothalamic tract of hypothalamus" EXACT [AUTO:patterns/p is_a: OBA:0005653 ! mammillothalamic tract of hypothalamus morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002990 ! mammillothalamic tract of hypothalamus +intersection_of: RO:0000052 UBERON:0002990 ! inheres in mammillothalamic tract of hypothalamus [Term] id: OBA:0005655 @@ -154274,7 +253629,7 @@ synonym: "size of dentate gyrus of hippocampal formation" EXACT [AUTO:patterns/p is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000812 ! dentate gyrus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001885 ! dentate gyrus of hippocampal formation +intersection_of: RO:0000052 UBERON:0001885 ! inheres in dentate gyrus of hippocampal formation [Term] id: OBA:0005656 @@ -154284,7 +253639,7 @@ synonym: "size of internal capsule of telencephalon" EXACT [AUTO:patterns/patter is_a: OBA:0004307 ! internal capsule of telencephalon morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001887 ! internal capsule of telencephalon +intersection_of: RO:0000052 UBERON:0001887 ! inheres in internal capsule of telencephalon [Term] id: OBA:0005657 @@ -154294,7 +253649,7 @@ synonym: "size of hippocampus fimbria" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0003005 ! hippocampus fimbria morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002310 ! hippocampus fimbria +intersection_of: RO:0000052 UBERON:0002310 ! inheres in hippocampus fimbria [Term] id: OBA:0005658 @@ -154304,7 +253659,7 @@ synonym: "size of striatum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004077 ! striatum morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002435 ! striatum +intersection_of: RO:0000052 UBERON:0002435 ! inheres in striatum [Term] id: OBA:0005659 @@ -154314,8 +253669,8 @@ synonym: "size of genu of facial nerve" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000778 ! nervous system tract morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014915 ! genu of facial nerve -relationship: inheres_in UBERON:0014915 ! genu of facial nerve +intersection_of: RO:0000052 UBERON:0014915 ! inheres in genu of facial nerve +relationship: RO:0000052 UBERON:0014915 ! inheres in genu of facial nerve [Term] id: OBA:0005660 @@ -154325,7 +253680,7 @@ synonym: "size of cerebellum interpositus nucleus" EXACT [AUTO:patterns/patterns is_a: OBA:0004946 ! cerebellum interpositus nucleus morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004073 ! cerebellum interpositus nucleus +intersection_of: RO:0000052 UBERON:0004073 ! inheres in cerebellum interpositus nucleus [Term] id: OBA:0005661 @@ -154335,7 +253690,7 @@ synonym: "size of piriform cortex" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004968 ! piriform cortex morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004725 ! piriform cortex +intersection_of: RO:0000052 UBERON:0004725 ! inheres in piriform cortex [Term] id: OBA:0005662 @@ -154345,7 +253700,7 @@ synonym: "size of secondary somatosensory cortex" EXACT [AUTO:patterns/patterns/ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000863 ! secondary somatosensory cortex morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008934 ! secondary somatosensory cortex +intersection_of: RO:0000052 UBERON:0008934 ! inheres in secondary somatosensory cortex [Term] id: OBA:0005663 @@ -154355,7 +253710,7 @@ synonym: "size of amygdala" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002761 ! basal ganglion size is_a: OBA:VT0000818 ! amygdala morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001876 ! amygdala +intersection_of: RO:0000052 UBERON:0001876 ! inheres in amygdala [Term] id: OBA:0005664 @@ -154365,7 +253720,7 @@ synonym: "size of habenula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004082 ! habenula morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001904 ! habenula +intersection_of: RO:0000052 UBERON:0001904 ! inheres in habenula [Term] id: OBA:0005665 @@ -154375,7 +253730,7 @@ synonym: "size of cochlear nucleus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005668 ! cochlear nucleus morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001720 ! cochlear nucleus +intersection_of: RO:0000052 UBERON:0001720 ! inheres in cochlear nucleus [Term] id: OBA:0005666 @@ -154385,7 +253740,7 @@ synonym: "size of dentate nucleus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0004942 ! dentate nucleus morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002132 ! dentate nucleus +intersection_of: RO:0000052 UBERON:0002132 ! inheres in dentate nucleus [Term] id: OBA:0005667 @@ -154395,8 +253750,8 @@ synonym: "morphology of retrosplenial region" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013531 ! retrosplenial region -relationship: inheres_in UBERON:0013531 ! retrosplenial region +intersection_of: RO:0000052 UBERON:0013531 ! inheres in retrosplenial region +relationship: RO:0000052 UBERON:0013531 ! inheres in retrosplenial region [Term] id: OBA:0005668 @@ -154406,8 +253761,8 @@ synonym: "morphology of cochlear nucleus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001720 ! cochlear nucleus -relationship: inheres_in UBERON:0001720 ! cochlear nucleus +intersection_of: RO:0000052 UBERON:0001720 ! inheres in cochlear nucleus +relationship: RO:0000052 UBERON:0001720 ! inheres in cochlear nucleus [Term] id: OBA:0005669 @@ -154417,8 +253772,8 @@ synonym: "amount of pharyngeal arch artery" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000301 ! head blood vessel quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004363 ! pharyngeal arch artery -relationship: inheres_in UBERON:0004363 ! pharyngeal arch artery +intersection_of: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery +relationship: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery [Term] id: OBA:0005670 @@ -154428,7 +253783,7 @@ synonym: "structure of pharyngeal arch artery" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003389 ! artery structure is_a: OBA:VT0004113 ! aortic arch morphology trait intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004363 ! pharyngeal arch artery +intersection_of: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery [Term] id: OBA:0005671 @@ -154438,8 +253793,8 @@ synonym: "morphology of cardiogenic plate" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004139 ! cardiogenic plate -relationship: inheres_in UBERON:0004139 ! cardiogenic plate +intersection_of: RO:0000052 UBERON:0004139 ! inheres in cardiogenic plate +relationship: RO:0000052 UBERON:0004139 ! inheres in cardiogenic plate [Term] id: OBA:0005672 @@ -154449,8 +253804,8 @@ synonym: "morphology of pericardial cavity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001074 ! pericardial cavity -relationship: inheres_in UBERON:0001074 ! pericardial cavity +intersection_of: RO:0000052 UBERON:0001074 ! inheres in pericardial cavity +relationship: RO:0000052 UBERON:0001074 ! inheres in pericardial cavity [Term] id: OBA:0005673 @@ -154460,8 +253815,8 @@ synonym: "morphology of aortic sac" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005089 ! coronary vessel morphology is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005432 ! aortic sac -relationship: inheres_in UBERON:0005432 ! aortic sac +intersection_of: RO:0000052 UBERON:0005432 ! inheres in aortic sac +relationship: RO:0000052 UBERON:0005432 ! inheres in aortic sac [Term] id: OBA:0005674 @@ -154471,8 +253826,8 @@ synonym: "morphology of apex of heart" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002098 ! apex of heart -relationship: inheres_in UBERON:0002098 ! apex of heart +intersection_of: RO:0000052 UBERON:0002098 ! inheres in apex of heart +relationship: RO:0000052 UBERON:0002098 ! inheres in apex of heart [Term] id: OBA:0005675 @@ -154482,7 +253837,7 @@ synonym: "amount of diencephalon" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000412 ! diencephalon quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001894 ! diencephalon +intersection_of: RO:0000052 UBERON:0001894 ! inheres in diencephalon [Term] id: OBA:0005676 @@ -154491,8 +253846,8 @@ def: "The morphology of a duodenal gland." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of duodenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0006000 ! submucosal gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001212 ! duodenal gland -relationship: inheres_in UBERON:0001212 ! duodenal gland +intersection_of: RO:0000052 UBERON:0001212 ! inheres in duodenal gland +relationship: RO:0000052 UBERON:0001212 ! inheres in duodenal gland [Term] id: OBA:0005677 @@ -154502,7 +253857,7 @@ synonym: "size of duodenal gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005676 ! duodenal gland morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001212 ! duodenal gland +intersection_of: RO:0000052 UBERON:0001212 ! inheres in duodenal gland [Term] id: OBA:0005678 @@ -154512,8 +253867,8 @@ synonym: "amount of duodenal gland" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001212 ! duodenal gland -relationship: inheres_in UBERON:0001212 ! duodenal gland +intersection_of: RO:0000052 UBERON:0001212 ! inheres in duodenal gland +relationship: RO:0000052 UBERON:0001212 ! inheres in duodenal gland [Term] id: OBA:0005679 @@ -154523,8 +253878,8 @@ synonym: "morphology of buccopharyngeal membrane" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006211 ! buccopharyngeal membrane -relationship: inheres_in UBERON:0006211 ! buccopharyngeal membrane +intersection_of: RO:0000052 UBERON:0006211 ! inheres in buccopharyngeal membrane +relationship: RO:0000052 UBERON:0006211 ! inheres in buccopharyngeal membrane [Term] id: OBA:0005680 @@ -154534,8 +253889,8 @@ synonym: "morphology of stomodeum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000930 ! stomodeum -relationship: inheres_in UBERON:0000930 ! stomodeum +intersection_of: RO:0000052 UBERON:0000930 ! inheres in stomodeum +relationship: RO:0000052 UBERON:0000930 ! inheres in stomodeum [Term] id: OBA:0005681 @@ -154544,8 +253899,8 @@ def: "The morphology of a upper lip." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of upper lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003769 ! lip morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001834 ! upper lip -relationship: inheres_in UBERON:0001834 ! upper lip +intersection_of: RO:0000052 UBERON:0001834 ! inheres in upper lip +relationship: RO:0000052 UBERON:0001834 ! inheres in upper lip [Term] id: OBA:0005682 @@ -154554,8 +253909,8 @@ def: "The morphology of a lower lip." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of lower lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003769 ! lip morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001835 ! lower lip -relationship: inheres_in UBERON:0001835 ! lower lip +intersection_of: RO:0000052 UBERON:0001835 ! inheres in lower lip +relationship: RO:0000052 UBERON:0001835 ! inheres in lower lip [Term] id: OBA:0005683 @@ -154565,8 +253920,8 @@ synonym: "morphology of rhombic lip" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006215 ! rhombic lip -relationship: inheres_in UBERON:0006215 ! rhombic lip +intersection_of: RO:0000052 UBERON:0006215 ! inheres in rhombic lip +relationship: RO:0000052 UBERON:0006215 ! inheres in rhombic lip [Term] id: OBA:0005684 @@ -154576,8 +253931,8 @@ synonym: "morphology of upper rhombic lip" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009841 ! upper rhombic lip -relationship: inheres_in UBERON:0009841 ! upper rhombic lip +intersection_of: RO:0000052 UBERON:0009841 ! inheres in upper rhombic lip +relationship: RO:0000052 UBERON:0009841 ! inheres in upper rhombic lip [Term] id: OBA:0005685 @@ -154587,8 +253942,8 @@ synonym: "morphology of lower rhombic lip" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009840 ! lower rhombic lip -relationship: inheres_in UBERON:0009840 ! lower rhombic lip +intersection_of: RO:0000052 UBERON:0009840 ! inheres in lower rhombic lip +relationship: RO:0000052 UBERON:0009840 ! inheres in lower rhombic lip [Term] id: OBA:0005686 @@ -154598,8 +253953,8 @@ synonym: "morphology of zone of polarizing activity" EXACT [AUTO:patterns/patter is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005414 ! zone of polarizing activity -relationship: inheres_in UBERON:0005414 ! zone of polarizing activity +intersection_of: RO:0000052 UBERON:0005414 ! inheres in zone of polarizing activity +relationship: RO:0000052 UBERON:0005414 ! inheres in zone of polarizing activity [Term] id: OBA:0005687 @@ -154608,8 +253963,8 @@ def: "The morphology of a decidua basalis." [AUTO:patterns/patterns/entity_attri synonym: "morphology of decidua basalis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000453 ! decidua basalis -relationship: inheres_in UBERON:0000453 ! decidua basalis +intersection_of: RO:0000052 UBERON:0000453 ! inheres in decidua basalis +relationship: RO:0000052 UBERON:0000453 ! inheres in decidua basalis [Term] id: OBA:0005688 @@ -154618,8 +253973,8 @@ def: "The morphology of a decidua capsularis." [AUTO:patterns/patterns/entity_at synonym: "morphology of decidua capsularis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004547 ! decidua capsularis -relationship: inheres_in UBERON:0004547 ! decidua capsularis +intersection_of: RO:0000052 UBERON:0004547 ! inheres in decidua capsularis +relationship: RO:0000052 UBERON:0004547 ! inheres in decidua capsularis [Term] id: OBA:0005689 @@ -154629,7 +253984,7 @@ synonym: "onset quality of limb development" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0002199 ! developmental process onset quality is_a: OBA:VT0006279 ! limb development trait intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0060173 ! limb development +intersection_of: RO:0000052 GO:0060173 ! inheres in limb development [Term] id: OBA:0005690 @@ -154638,8 +253993,8 @@ def: "The morphology of a external ectoderm." [AUTO:patterns/patterns/entity_att synonym: "morphology of external ectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000076 ! external ectoderm -relationship: inheres_in UBERON:0000076 ! external ectoderm +intersection_of: RO:0000052 UBERON:0000076 ! inheres in external ectoderm +relationship: RO:0000052 UBERON:0000076 ! inheres in external ectoderm [Term] id: OBA:0005691 @@ -154648,8 +254003,8 @@ def: "The morphology of a optic fissure." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of optic fissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005412 ! optic fissure -relationship: inheres_in UBERON:0005412 ! optic fissure +intersection_of: RO:0000052 UBERON:0005412 ! inheres in optic fissure +relationship: RO:0000052 UBERON:0005412 ! inheres in optic fissure [Term] id: OBA:0005692 @@ -154659,8 +254014,8 @@ synonym: "morphology of hyaloid artery" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002270 ! hyaloid artery -relationship: inheres_in UBERON:0002270 ! hyaloid artery +intersection_of: RO:0000052 UBERON:0002270 ! inheres in hyaloid artery +relationship: RO:0000052 UBERON:0002270 ! inheres in hyaloid artery [Term] id: OBA:0005693 @@ -154670,8 +254025,8 @@ synonym: "morphology of neuropore" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005077 ! neuropore -relationship: inheres_in UBERON:0005077 ! neuropore +intersection_of: RO:0000052 UBERON:0005077 ! inheres in neuropore +relationship: RO:0000052 UBERON:0005077 ! inheres in neuropore [Term] id: OBA:0005694 @@ -154680,8 +254035,8 @@ def: "The morphology of a anterior neuropore." [AUTO:patterns/patterns/entity_at synonym: "morphology of anterior neuropore" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005693 ! neuropore morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005070 ! anterior neuropore -relationship: inheres_in UBERON:0005070 ! anterior neuropore +intersection_of: RO:0000052 UBERON:0005070 ! inheres in anterior neuropore +relationship: RO:0000052 UBERON:0005070 ! inheres in anterior neuropore [Term] id: OBA:0005695 @@ -154690,8 +254045,8 @@ def: "The morphology of a posterior neuropore." [AUTO:patterns/patterns/entity_a synonym: "morphology of posterior neuropore" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005693 ! neuropore morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005071 ! posterior neuropore -relationship: inheres_in UBERON:0005071 ! posterior neuropore +intersection_of: RO:0000052 UBERON:0005071 ! inheres in posterior neuropore +relationship: RO:0000052 UBERON:0005071 ! inheres in posterior neuropore [Term] id: OBA:0005696 @@ -154701,8 +254056,8 @@ synonym: "rate of cell death" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008219 ! cell death -relationship: inheres_in GO:0008219 ! cell death +intersection_of: RO:0000052 GO:0008219 ! inheres in cell death +relationship: RO:0000052 GO:0008219 ! inheres in cell death [Term] id: OBA:0005697 @@ -154712,7 +254067,7 @@ synonym: "rate of peroxidase activity" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000714 ! peroxidase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004601 ! peroxidase activity +intersection_of: RO:0000052 GO:0004601 ! inheres in peroxidase activity [Term] id: OBA:0005698 @@ -154722,7 +254077,7 @@ synonym: "rate of catechol O-methyltransferase activity" EXACT [AUTO:patterns/pa is_a: OBA:1000766 ! catechol O-methyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0016206 ! catechol O-methyltransferase activity +intersection_of: RO:0000052 GO:0016206 ! inheres in catechol O-methyltransferase activity [Term] id: OBA:0005699 @@ -154732,7 +254087,7 @@ synonym: "rate of choline O-acetyltransferase activity" EXACT [AUTO:patterns/pat is_a: OBA:1000776 ! choline O-acetyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004102 ! choline O-acetyltransferase activity +intersection_of: RO:0000052 GO:0004102 ! inheres in choline O-acetyltransferase activity [Term] id: OBA:0005700 @@ -154742,7 +254097,7 @@ synonym: "rate of glutamate decarboxylase activity" EXACT [AUTO:patterns/pattern is_a: OBA:1000744 ! glutamate decarboxylase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004351 ! glutamate decarboxylase activity +intersection_of: RO:0000052 GO:0004351 ! inheres in glutamate decarboxylase activity [Term] id: OBA:0005701 @@ -154752,7 +254107,7 @@ synonym: "rate of nicotinamide N-methyltransferase activity" EXACT [AUTO:pattern is_a: OBA:1000894 ! nicotinamide N-methyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008112 ! nicotinamide N-methyltransferase activity +intersection_of: RO:0000052 GO:0008112 ! inheres in nicotinamide N-methyltransferase activity [Term] id: OBA:0005702 @@ -154762,7 +254117,7 @@ synonym: "rate of acetylcholinesterase activity" EXACT [AUTO:patterns/patterns/e is_a: OBA:0006015 ! cholinesterase activity rate is_a: OBA:1000926 ! acetylcholinesterase activity quality intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0003990 ! acetylcholinesterase activity +intersection_of: RO:0000052 GO:0003990 ! inheres in acetylcholinesterase activity [Term] id: OBA:0005703 @@ -154772,7 +254127,7 @@ synonym: "rate of monoamine oxidase activity" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000811 ! monoamine oxidase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0097621 ! monoamine oxidase activity +intersection_of: RO:0000052 GO:0097621 ! inheres in monoamine oxidase activity [Term] id: OBA:0005704 @@ -154782,7 +254137,7 @@ synonym: "rate of 5-aminolevulinate synthase activity" EXACT [AUTO:patterns/patt is_a: OBA:1000716 ! 5-aminolevulinate synthase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0003870 ! 5-aminolevulinate synthase activity +intersection_of: RO:0000052 GO:0003870 ! inheres in 5-aminolevulinate synthase activity [Term] id: OBA:0005705 @@ -154792,7 +254147,7 @@ synonym: "structure of brain ventricle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000822 ! brain ventricle morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0004086 ! brain ventricle +intersection_of: RO:0000052 UBERON:0004086 ! inheres in brain ventricle [Term] id: OBA:0005706 @@ -154802,8 +254157,8 @@ synonym: "morphology of pleural cavity" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002402 ! pleural cavity -relationship: inheres_in UBERON:0002402 ! pleural cavity +intersection_of: RO:0000052 UBERON:0002402 ! inheres in pleural cavity +relationship: RO:0000052 UBERON:0002402 ! inheres in pleural cavity [Term] id: OBA:0005707 @@ -154817,8 +254172,8 @@ def: "The morphology of a hemangioblast." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of hemangioblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002418 ! hemangioblast -relationship: inheres_in CL:0002418 ! hemangioblast +intersection_of: RO:0000052 CL:0002418 ! inheres in hemangioblast +relationship: RO:0000052 CL:0002418 ! inheres in hemangioblast [Term] id: OBA:0005709 @@ -154828,8 +254183,8 @@ synonym: "amount of hemangioblast" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002418 ! hemangioblast -relationship: inheres_in CL:0002418 ! hemangioblast +intersection_of: RO:0000052 CL:0002418 ! inheres in hemangioblast +relationship: RO:0000052 CL:0002418 ! inheres in hemangioblast [Term] id: OBA:0005710 @@ -154839,8 +254194,8 @@ synonym: "morphology of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000974 ! neck -relationship: inheres_in UBERON:0000974 ! neck +intersection_of: RO:0000052 UBERON:0000974 ! inheres in neck +relationship: RO:0000052 UBERON:0000974 ! inheres in neck [Term] id: OBA:0005711 @@ -154849,8 +254204,8 @@ def: "The morphology of a uterine spiral artery." [AUTO:patterns/patterns/entity synonym: "morphology of uterine spiral artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0015171 ! uterine spiral artery -relationship: inheres_in UBERON:0015171 ! uterine spiral artery +intersection_of: RO:0000052 UBERON:0015171 ! inheres in uterine spiral artery +relationship: RO:0000052 UBERON:0015171 ! inheres in uterine spiral artery [Term] id: OBA:0005712 @@ -154860,8 +254215,8 @@ synonym: "morphology of somite border" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0015178 ! somite border -relationship: inheres_in UBERON:0015178 ! somite border +intersection_of: RO:0000052 UBERON:0015178 ! inheres in somite border +relationship: RO:0000052 UBERON:0015178 ! inheres in somite border [Term] id: OBA:0005713 @@ -154871,7 +254226,7 @@ synonym: "morphology of internal carotid artery" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003926 ! carotid artery segment morphology is_a: OBA:1000374 ! internal carotid artery quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001532 ! internal carotid artery +intersection_of: RO:0000052 UBERON:0001532 ! inheres in internal carotid artery [Term] id: OBA:0005714 @@ -154881,7 +254236,7 @@ synonym: "morphology of external carotid artery" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003926 ! carotid artery segment morphology is_a: OBA:1000287 ! external carotid artery quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001070 ! external carotid artery +intersection_of: RO:0000052 UBERON:0001070 ! inheres in external carotid artery [Term] id: OBA:0005715 @@ -154890,8 +254245,8 @@ def: "The morphology of a polar body." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of polar body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004240 ! female germ cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002090 ! polar body -relationship: inheres_in CL:0002090 ! polar body +intersection_of: RO:0000052 CL:0002090 ! inheres in polar body +relationship: RO:0000052 CL:0002090 ! inheres in polar body [Term] id: OBA:0005716 @@ -154900,8 +254255,8 @@ def: "The morphology of a migratory cranial neural crest cell." [AUTO:patterns/p synonym: "morphology of migratory cranial neural crest cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004873 ! migratory neural crest cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000008 ! migratory cranial neural crest cell -relationship: inheres_in CL:0000008 ! migratory cranial neural crest cell +intersection_of: RO:0000052 CL:0000008 ! inheres in migratory cranial neural crest cell +relationship: RO:0000052 CL:0000008 ! inheres in migratory cranial neural crest cell [Term] id: OBA:0005717 @@ -154910,8 +254265,8 @@ def: "The morphology of a alpha-beta T cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000789 ! alpha-beta T cell -relationship: inheres_in CL:0000789 ! alpha-beta T cell +intersection_of: RO:0000052 CL:0000789 ! inheres in alpha-beta T cell +relationship: RO:0000052 CL:0000789 ! inheres in alpha-beta T cell [Term] id: OBA:0005718 @@ -154920,8 +254275,8 @@ def: "The amount of a alpha-beta T cell." [AUTO:patterns/patterns/entity_attribu synonym: "amount of alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000789 ! alpha-beta T cell -relationship: inheres_in CL:0000789 ! alpha-beta T cell +intersection_of: RO:0000052 CL:0000789 ! inheres in alpha-beta T cell +relationship: RO:0000052 CL:0000789 ! inheres in alpha-beta T cell [Term] id: OBA:0005719 @@ -154930,8 +254285,8 @@ def: "The morphology of a rhombomere 1." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005499 ! rhombomere 1 -relationship: inheres_in UBERON:0005499 ! rhombomere 1 +intersection_of: RO:0000052 UBERON:0005499 ! inheres in rhombomere 1 +relationship: RO:0000052 UBERON:0005499 ! inheres in rhombomere 1 [Term] id: OBA:0005720 @@ -154941,7 +254296,7 @@ synonym: "size of rhombomere 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005719 ! rhombomere 1 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005499 ! rhombomere 1 +intersection_of: RO:0000052 UBERON:0005499 ! inheres in rhombomere 1 [Term] id: OBA:0005721 @@ -154951,8 +254306,8 @@ synonym: "amount of rhombomere 1" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005499 ! rhombomere 1 -relationship: inheres_in UBERON:0005499 ! rhombomere 1 +intersection_of: RO:0000052 UBERON:0005499 ! inheres in rhombomere 1 +relationship: RO:0000052 UBERON:0005499 ! inheres in rhombomere 1 [Term] id: OBA:0005722 @@ -154961,8 +254316,8 @@ def: "The morphology of a rhombomere 2." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005569 ! rhombomere 2 -relationship: inheres_in UBERON:0005569 ! rhombomere 2 +intersection_of: RO:0000052 UBERON:0005569 ! inheres in rhombomere 2 +relationship: RO:0000052 UBERON:0005569 ! inheres in rhombomere 2 [Term] id: OBA:0005723 @@ -154972,7 +254327,7 @@ synonym: "size of rhombomere 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005722 ! rhombomere 2 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005569 ! rhombomere 2 +intersection_of: RO:0000052 UBERON:0005569 ! inheres in rhombomere 2 [Term] id: OBA:0005724 @@ -154982,8 +254337,8 @@ synonym: "amount of rhombomere 2" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005569 ! rhombomere 2 -relationship: inheres_in UBERON:0005569 ! rhombomere 2 +intersection_of: RO:0000052 UBERON:0005569 ! inheres in rhombomere 2 +relationship: RO:0000052 UBERON:0005569 ! inheres in rhombomere 2 [Term] id: OBA:0005725 @@ -154992,8 +254347,8 @@ def: "The morphology of a rhombomere 3." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005507 ! rhombomere 3 -relationship: inheres_in UBERON:0005507 ! rhombomere 3 +intersection_of: RO:0000052 UBERON:0005507 ! inheres in rhombomere 3 +relationship: RO:0000052 UBERON:0005507 ! inheres in rhombomere 3 [Term] id: OBA:0005726 @@ -155003,7 +254358,7 @@ synonym: "size of rhombomere 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005725 ! rhombomere 3 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005507 ! rhombomere 3 +intersection_of: RO:0000052 UBERON:0005507 ! inheres in rhombomere 3 [Term] id: OBA:0005727 @@ -155013,8 +254368,8 @@ synonym: "amount of rhombomere 3" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005507 ! rhombomere 3 -relationship: inheres_in UBERON:0005507 ! rhombomere 3 +intersection_of: RO:0000052 UBERON:0005507 ! inheres in rhombomere 3 +relationship: RO:0000052 UBERON:0005507 ! inheres in rhombomere 3 [Term] id: OBA:0005728 @@ -155023,8 +254378,8 @@ def: "The morphology of a rhombomere 4." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005511 ! rhombomere 4 -relationship: inheres_in UBERON:0005511 ! rhombomere 4 +intersection_of: RO:0000052 UBERON:0005511 ! inheres in rhombomere 4 +relationship: RO:0000052 UBERON:0005511 ! inheres in rhombomere 4 [Term] id: OBA:0005729 @@ -155034,7 +254389,7 @@ synonym: "size of rhombomere 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005728 ! rhombomere 4 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005511 ! rhombomere 4 +intersection_of: RO:0000052 UBERON:0005511 ! inheres in rhombomere 4 [Term] id: OBA:0005730 @@ -155044,8 +254399,8 @@ synonym: "amount of rhombomere 4" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005511 ! rhombomere 4 -relationship: inheres_in UBERON:0005511 ! rhombomere 4 +intersection_of: RO:0000052 UBERON:0005511 ! inheres in rhombomere 4 +relationship: RO:0000052 UBERON:0005511 ! inheres in rhombomere 4 [Term] id: OBA:0005731 @@ -155054,8 +254409,8 @@ def: "The morphology of a rhombomere 5." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005515 ! rhombomere 5 -relationship: inheres_in UBERON:0005515 ! rhombomere 5 +intersection_of: RO:0000052 UBERON:0005515 ! inheres in rhombomere 5 +relationship: RO:0000052 UBERON:0005515 ! inheres in rhombomere 5 [Term] id: OBA:0005732 @@ -155065,7 +254420,7 @@ synonym: "size of rhombomere 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005731 ! rhombomere 5 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005515 ! rhombomere 5 +intersection_of: RO:0000052 UBERON:0005515 ! inheres in rhombomere 5 [Term] id: OBA:0005733 @@ -155075,8 +254430,8 @@ synonym: "amount of rhombomere 5" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005515 ! rhombomere 5 -relationship: inheres_in UBERON:0005515 ! rhombomere 5 +intersection_of: RO:0000052 UBERON:0005515 ! inheres in rhombomere 5 +relationship: RO:0000052 UBERON:0005515 ! inheres in rhombomere 5 [Term] id: OBA:0005734 @@ -155085,8 +254440,8 @@ def: "The morphology of a rhombomere 6." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 6" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005519 ! rhombomere 6 -relationship: inheres_in UBERON:0005519 ! rhombomere 6 +intersection_of: RO:0000052 UBERON:0005519 ! inheres in rhombomere 6 +relationship: RO:0000052 UBERON:0005519 ! inheres in rhombomere 6 [Term] id: OBA:0005735 @@ -155096,7 +254451,7 @@ synonym: "size of rhombomere 6" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005734 ! rhombomere 6 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005519 ! rhombomere 6 +intersection_of: RO:0000052 UBERON:0005519 ! inheres in rhombomere 6 [Term] id: OBA:0005736 @@ -155106,8 +254461,8 @@ synonym: "amount of rhombomere 6" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005519 ! rhombomere 6 -relationship: inheres_in UBERON:0005519 ! rhombomere 6 +intersection_of: RO:0000052 UBERON:0005519 ! inheres in rhombomere 6 +relationship: RO:0000052 UBERON:0005519 ! inheres in rhombomere 6 [Term] id: OBA:0005737 @@ -155116,8 +254471,8 @@ def: "The morphology of a rhombomere 7." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 7" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005523 ! rhombomere 7 -relationship: inheres_in UBERON:0005523 ! rhombomere 7 +intersection_of: RO:0000052 UBERON:0005523 ! inheres in rhombomere 7 +relationship: RO:0000052 UBERON:0005523 ! inheres in rhombomere 7 [Term] id: OBA:0005738 @@ -155127,7 +254482,7 @@ synonym: "size of rhombomere 7" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005737 ! rhombomere 7 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005523 ! rhombomere 7 +intersection_of: RO:0000052 UBERON:0005523 ! inheres in rhombomere 7 [Term] id: OBA:0005739 @@ -155137,8 +254492,8 @@ synonym: "amount of rhombomere 7" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005523 ! rhombomere 7 -relationship: inheres_in UBERON:0005523 ! rhombomere 7 +intersection_of: RO:0000052 UBERON:0005523 ! inheres in rhombomere 7 +relationship: RO:0000052 UBERON:0005523 ! inheres in rhombomere 7 [Term] id: OBA:0005740 @@ -155147,8 +254502,8 @@ def: "The morphology of a rhombomere 8." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of rhombomere 8" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000933 ! rhombomere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005527 ! rhombomere 8 -relationship: inheres_in UBERON:0005527 ! rhombomere 8 +intersection_of: RO:0000052 UBERON:0005527 ! inheres in rhombomere 8 +relationship: RO:0000052 UBERON:0005527 ! inheres in rhombomere 8 [Term] id: OBA:0005741 @@ -155158,7 +254513,7 @@ synonym: "size of rhombomere 8" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005740 ! rhombomere 8 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005527 ! rhombomere 8 +intersection_of: RO:0000052 UBERON:0005527 ! inheres in rhombomere 8 [Term] id: OBA:0005742 @@ -155168,8 +254523,8 @@ synonym: "amount of rhombomere 8" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005527 ! rhombomere 8 -relationship: inheres_in UBERON:0005527 ! rhombomere 8 +intersection_of: RO:0000052 UBERON:0005527 ! inheres in rhombomere 8 +relationship: RO:0000052 UBERON:0005527 ! inheres in rhombomere 8 [Term] id: OBA:0005743 @@ -155178,8 +254533,8 @@ def: "The morphology of a migratory trunk neural crest cell." [AUTO:patterns/pat synonym: "morphology of migratory trunk neural crest cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004873 ! migratory neural crest cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000011 ! migratory trunk neural crest cell -relationship: inheres_in CL:0000011 ! migratory trunk neural crest cell +intersection_of: RO:0000052 CL:0000011 ! inheres in migratory trunk neural crest cell +relationship: RO:0000052 CL:0000011 ! inheres in migratory trunk neural crest cell [Term] id: OBA:0005744 @@ -155190,7 +254545,7 @@ is_a: OBA:1000188 ! gingiva quality is_a: OBA:VT0003745 ! mouth mucosa morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001828 ! gingiva +intersection_of: RO:0000052 UBERON:0001828 ! inheres in gingiva [Term] id: OBA:0005745 @@ -155200,7 +254555,7 @@ synonym: "color saturation of gingiva" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000188 ! gingiva quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0001828 ! gingiva +intersection_of: RO:0000052 UBERON:0001828 ! inheres in gingiva [Term] id: OBA:0005746 @@ -155209,8 +254564,8 @@ def: "The morphology of a forelimb bud." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of forelimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005650 ! limb bud morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005417 ! forelimb bud -relationship: inheres_in UBERON:0005417 ! forelimb bud +intersection_of: RO:0000052 UBERON:0005417 ! inheres in forelimb bud +relationship: RO:0000052 UBERON:0005417 ! inheres in forelimb bud [Term] id: OBA:0005747 @@ -155219,8 +254574,8 @@ def: "The amount of a forelimb bud." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of forelimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004017 ! limb bud amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005417 ! forelimb bud -relationship: inheres_in UBERON:0005417 ! forelimb bud +intersection_of: RO:0000052 UBERON:0005417 ! inheres in forelimb bud +relationship: RO:0000052 UBERON:0005417 ! inheres in forelimb bud [Term] id: OBA:0005748 @@ -155230,7 +254585,7 @@ synonym: "size of forelimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004018 ! limb bud size is_a: OBA:0005746 ! forelimb bud morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005417 ! forelimb bud +intersection_of: RO:0000052 UBERON:0005417 ! inheres in forelimb bud [Term] id: OBA:0005749 @@ -155239,8 +254594,8 @@ def: "The morphology of a hindlimb bud." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of hindlimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005650 ! limb bud morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005418 ! hindlimb bud -relationship: inheres_in UBERON:0005418 ! hindlimb bud +intersection_of: RO:0000052 UBERON:0005418 ! inheres in hindlimb bud +relationship: RO:0000052 UBERON:0005418 ! inheres in hindlimb bud [Term] id: OBA:0005750 @@ -155249,8 +254604,8 @@ def: "The amount of a hindlimb bud." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of hindlimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004017 ! limb bud amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005418 ! hindlimb bud -relationship: inheres_in UBERON:0005418 ! hindlimb bud +intersection_of: RO:0000052 UBERON:0005418 ! inheres in hindlimb bud +relationship: RO:0000052 UBERON:0005418 ! inheres in hindlimb bud [Term] id: OBA:0005751 @@ -155260,7 +254615,7 @@ synonym: "size of hindlimb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004018 ! limb bud size is_a: OBA:0005749 ! hindlimb bud morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005418 ! hindlimb bud +intersection_of: RO:0000052 UBERON:0005418 ! inheres in hindlimb bud [Term] id: OBA:0005752 @@ -155270,7 +254625,7 @@ synonym: "degeneration of trigeminal ganglion" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0001092 ! trigeminal ganglion morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001675 ! trigeminal ganglion +intersection_of: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion [Term] id: OBA:0005753 @@ -155280,7 +254635,7 @@ synonym: "structure of chordate pharynx" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0002234 ! pharynx morphology trait is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001042 ! chordate pharynx +intersection_of: RO:0000052 UBERON:0001042 ! inheres in chordate pharynx [Term] id: OBA:0005754 @@ -155290,7 +254645,7 @@ synonym: "branchiness of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003051 ! tail shape trait is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:0005755 @@ -155300,8 +254655,8 @@ synonym: "position of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002415 ! tail -relationship: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail +relationship: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:0005756 @@ -155311,8 +254666,8 @@ synonym: "morphology of post-anal tail tip" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010162 ! post-anal tail tip -relationship: inheres_in UBERON:0010162 ! post-anal tail tip +intersection_of: RO:0000052 UBERON:0010162 ! inheres in post-anal tail tip +relationship: RO:0000052 UBERON:0010162 ! inheres in post-anal tail tip [Term] id: OBA:0005757 @@ -155322,7 +254677,7 @@ synonym: "length of post-anal tail bud" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0003401 ! tail bud size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002533 ! post-anal tail bud +intersection_of: RO:0000052 UBERON:0002533 ! inheres in post-anal tail bud [Term] id: OBA:0005758 @@ -155332,7 +254687,7 @@ synonym: "amount of placenta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000620 ! placenta quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:0005759 @@ -155342,8 +254697,8 @@ synonym: "amount of trigeminal ganglion" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000203 ! cranial ganglion quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001675 ! trigeminal ganglion -relationship: inheres_in UBERON:0001675 ! trigeminal ganglion +intersection_of: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion +relationship: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion [Term] id: OBA:0005760 @@ -155353,8 +254708,8 @@ synonym: "amount of anterior definitive endoderm" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0004046 ! anterior definitive endoderm -relationship: inheres_in UBERON:0004046 ! anterior definitive endoderm +intersection_of: RO:0000052 UBERON:0004046 ! inheres in anterior definitive endoderm +relationship: RO:0000052 UBERON:0004046 ! inheres in anterior definitive endoderm [Term] id: OBA:0005761 @@ -155364,8 +254719,8 @@ synonym: "morphology of basilar artery" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0005507 ! systemic artery morphology is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001633 ! basilar artery -relationship: inheres_in UBERON:0001633 ! basilar artery +intersection_of: RO:0000052 UBERON:0001633 ! inheres in basilar artery +relationship: RO:0000052 UBERON:0001633 ! inheres in basilar artery [Term] id: OBA:0005762 @@ -155375,7 +254730,7 @@ synonym: "size of basilar artery" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000032 ! blood vessel size is_a: OBA:0005761 ! basilar artery morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001633 ! basilar artery +intersection_of: RO:0000052 UBERON:0001633 ! inheres in basilar artery [Term] id: OBA:0005763 @@ -155385,8 +254740,8 @@ synonym: "amount of sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001821 ! sebaceous gland -relationship: inheres_in UBERON:0001821 ! sebaceous gland +intersection_of: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland +relationship: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland [Term] id: OBA:0005764 @@ -155396,8 +254751,8 @@ synonym: "amount of head mesenchyme" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005253 ! head mesenchyme -relationship: inheres_in UBERON:0005253 ! head mesenchyme +intersection_of: RO:0000052 UBERON:0005253 ! inheres in head mesenchyme +relationship: RO:0000052 UBERON:0005253 ! inheres in head mesenchyme [Term] id: OBA:0005765 @@ -155407,7 +254762,7 @@ synonym: "size of head mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005369 ! head mesenchyme morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005253 ! head mesenchyme +intersection_of: RO:0000052 UBERON:0005253 ! inheres in head mesenchyme [Term] id: OBA:0005766 @@ -155417,8 +254772,8 @@ synonym: "morphology of cilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005929 ! cilium -relationship: inheres_in GO:0005929 ! cilium +intersection_of: RO:0000052 GO:0005929 ! inheres in cilium +relationship: RO:0000052 GO:0005929 ! inheres in cilium [Term] id: OBA:0005767 @@ -155432,8 +254787,8 @@ def: "The morphology of a non-motile cilium." [AUTO:patterns/patterns/entity_att synonym: "morphology of non-motile cilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005766 ! cilium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097730 ! non-motile cilium -relationship: inheres_in GO:0097730 ! non-motile cilium +intersection_of: RO:0000052 GO:0097730 ! inheres in non-motile cilium +relationship: RO:0000052 GO:0097730 ! inheres in non-motile cilium [Term] id: OBA:0005769 @@ -155442,8 +254797,8 @@ def: "The morphology of a motile cilium." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of motile cilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005766 ! cilium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0031514 ! motile cilium -relationship: inheres_in GO:0031514 ! motile cilium +intersection_of: RO:0000052 GO:0031514 ! inheres in motile cilium +relationship: RO:0000052 GO:0031514 ! inheres in motile cilium [Term] id: OBA:0005770 @@ -155453,8 +254808,8 @@ synonym: "amount of endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000925 ! endoderm -relationship: inheres_in UBERON:0000925 ! endoderm +intersection_of: RO:0000052 UBERON:0000925 ! inheres in endoderm +relationship: RO:0000052 UBERON:0000925 ! inheres in endoderm [Term] id: OBA:0005771 @@ -155464,8 +254819,8 @@ synonym: "functionality of cilium" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0005929 ! cilium -relationship: inheres_in GO:0005929 ! cilium +intersection_of: RO:0000052 GO:0005929 ! inheres in cilium +relationship: RO:0000052 GO:0005929 ! inheres in cilium [Term] id: OBA:0005772 @@ -155474,8 +254829,8 @@ def: "The functionality of a motile cilium." [AUTO:patterns/patterns/entity_attr synonym: "functionality of motile cilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005771 ! cilium functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0031514 ! motile cilium -relationship: inheres_in GO:0031514 ! motile cilium +intersection_of: RO:0000052 GO:0031514 ! inheres in motile cilium +relationship: RO:0000052 GO:0031514 ! inheres in motile cilium [Term] id: OBA:0005773 @@ -155489,8 +254844,8 @@ def: "The functionality of a non-motile cilium." [AUTO:patterns/patterns/entity_ synonym: "functionality of non-motile cilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005771 ! cilium functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0097730 ! non-motile cilium -relationship: inheres_in GO:0097730 ! non-motile cilium +intersection_of: RO:0000052 GO:0097730 ! inheres in non-motile cilium +relationship: RO:0000052 GO:0097730 ! inheres in non-motile cilium [Term] id: OBA:0005775 @@ -155500,8 +254855,8 @@ synonym: "amount of ectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000924 ! ectoderm -relationship: inheres_in UBERON:0000924 ! ectoderm +intersection_of: RO:0000052 UBERON:0000924 ! inheres in ectoderm +relationship: RO:0000052 UBERON:0000924 ! inheres in ectoderm [Term] id: OBA:0005776 @@ -155511,8 +254866,8 @@ synonym: "morphology of substantia nigra pars reticulata" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001966 ! substantia nigra pars reticulata -relationship: inheres_in UBERON:0001966 ! substantia nigra pars reticulata +intersection_of: RO:0000052 UBERON:0001966 ! inheres in substantia nigra pars reticulata +relationship: RO:0000052 UBERON:0001966 ! inheres in substantia nigra pars reticulata [Term] id: OBA:0005777 @@ -155522,8 +254877,8 @@ synonym: "morphology of substantia nigra pars compacta" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001965 ! substantia nigra pars compacta -relationship: inheres_in UBERON:0001965 ! substantia nigra pars compacta +intersection_of: RO:0000052 UBERON:0001965 ! inheres in substantia nigra pars compacta +relationship: RO:0000052 UBERON:0001965 ! inheres in substantia nigra pars compacta [Term] id: OBA:0005778 @@ -155532,8 +254887,8 @@ def: "The morphology of a pharyngeal pouch 1." [AUTO:patterns/patterns/entity_at synonym: "morphology of pharyngeal pouch 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006031 ! branchial pouch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007122 ! pharyngeal pouch 1 -relationship: inheres_in UBERON:0007122 ! pharyngeal pouch 1 +intersection_of: RO:0000052 UBERON:0007122 ! inheres in pharyngeal pouch 1 +relationship: RO:0000052 UBERON:0007122 ! inheres in pharyngeal pouch 1 [Term] id: OBA:0005779 @@ -155542,8 +254897,8 @@ def: "The morphology of a pharyngeal pouch 2." [AUTO:patterns/patterns/entity_at synonym: "morphology of pharyngeal pouch 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006031 ! branchial pouch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007123 ! pharyngeal pouch 2 -relationship: inheres_in UBERON:0007123 ! pharyngeal pouch 2 +intersection_of: RO:0000052 UBERON:0007123 ! inheres in pharyngeal pouch 2 +relationship: RO:0000052 UBERON:0007123 ! inheres in pharyngeal pouch 2 [Term] id: OBA:0005780 @@ -155553,8 +254908,8 @@ synonym: "amount of pharyngeal pouch 2" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007123 ! pharyngeal pouch 2 -relationship: inheres_in UBERON:0007123 ! pharyngeal pouch 2 +intersection_of: RO:0000052 UBERON:0007123 ! inheres in pharyngeal pouch 2 +relationship: RO:0000052 UBERON:0007123 ! inheres in pharyngeal pouch 2 [Term] id: OBA:0005781 @@ -155563,8 +254918,8 @@ def: "The morphology of a pharyngeal pouch 3." [AUTO:patterns/patterns/entity_at synonym: "morphology of pharyngeal pouch 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006031 ! branchial pouch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007124 ! pharyngeal pouch 3 -relationship: inheres_in UBERON:0007124 ! pharyngeal pouch 3 +intersection_of: RO:0000052 UBERON:0007124 ! inheres in pharyngeal pouch 3 +relationship: RO:0000052 UBERON:0007124 ! inheres in pharyngeal pouch 3 [Term] id: OBA:0005782 @@ -155574,8 +254929,8 @@ synonym: "amount of pharyngeal pouch 3" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007124 ! pharyngeal pouch 3 -relationship: inheres_in UBERON:0007124 ! pharyngeal pouch 3 +intersection_of: RO:0000052 UBERON:0007124 ! inheres in pharyngeal pouch 3 +relationship: RO:0000052 UBERON:0007124 ! inheres in pharyngeal pouch 3 [Term] id: OBA:0005783 @@ -155586,8 +254941,8 @@ is_a: OBA:0003297 ! respiratory system epithelium morphology is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005879 ! pharyngeal cleft -relationship: inheres_in UBERON:0005879 ! pharyngeal cleft +intersection_of: RO:0000052 UBERON:0005879 ! inheres in pharyngeal cleft +relationship: RO:0000052 UBERON:0005879 ! inheres in pharyngeal cleft [Term] id: OBA:0005784 @@ -155597,8 +254952,8 @@ synonym: "morphology of pharyngeal membrane" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009210 ! pharyngeal membrane -relationship: inheres_in UBERON:0009210 ! pharyngeal membrane +intersection_of: RO:0000052 UBERON:0009210 ! inheres in pharyngeal membrane +relationship: RO:0000052 UBERON:0009210 ! inheres in pharyngeal membrane [Term] id: OBA:0005785 @@ -155608,8 +254963,8 @@ synonym: "morphology of foramen cecum of tongue" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006699 ! foramen cecum of tongue -relationship: inheres_in UBERON:0006699 ! foramen cecum of tongue +intersection_of: RO:0000052 UBERON:0006699 ! inheres in foramen cecum of tongue +relationship: RO:0000052 UBERON:0006699 ! inheres in foramen cecum of tongue [Term] id: OBA:0005786 @@ -155619,8 +254974,8 @@ synonym: "morphology of thyroglossal duct" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002254 ! thyroglossal duct -relationship: inheres_in UBERON:0002254 ! thyroglossal duct +intersection_of: RO:0000052 UBERON:0002254 ! inheres in thyroglossal duct +relationship: RO:0000052 UBERON:0002254 ! inheres in thyroglossal duct [Term] id: OBA:0005787 @@ -155630,7 +254985,7 @@ synonym: "degeneration of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002021 ! ovary structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:0005788 @@ -155639,8 +254994,8 @@ def: "The rate of a skeletal muscle tissue regeneration." [AUTO:patterns/pattern synonym: "rate of skeletal muscle tissue regeneration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002215 ! growth rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0043403 ! skeletal muscle tissue regeneration -relationship: inheres_in GO:0043403 ! skeletal muscle tissue regeneration +intersection_of: RO:0000052 GO:0043403 ! inheres in skeletal muscle tissue regeneration +relationship: RO:0000052 GO:0043403 ! inheres in skeletal muscle tissue regeneration [Term] id: OBA:0005789 @@ -155649,8 +255004,8 @@ def: "The rate of a cardiac muscle tissue regeneration." [AUTO:patterns/patterns synonym: "rate of cardiac muscle tissue regeneration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002215 ! growth rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0061026 ! cardiac muscle tissue regeneration -relationship: inheres_in GO:0061026 ! cardiac muscle tissue regeneration +intersection_of: RO:0000052 GO:0061026 ! inheres in cardiac muscle tissue regeneration +relationship: RO:0000052 GO:0061026 ! inheres in cardiac muscle tissue regeneration [Term] id: OBA:0005790 @@ -155659,8 +255014,8 @@ def: "The morphology of a dental pulp." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of dental pulp" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001754 ! dental pulp -relationship: inheres_in UBERON:0001754 ! dental pulp +intersection_of: RO:0000052 UBERON:0001754 ! inheres in dental pulp +relationship: RO:0000052 UBERON:0001754 ! inheres in dental pulp [Term] id: OBA:0005791 @@ -155670,8 +255025,8 @@ synonym: "morphology of extracellular matrix" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0031012 ! extracellular matrix -relationship: inheres_in GO:0031012 ! extracellular matrix +intersection_of: RO:0000052 GO:0031012 ! inheres in extracellular matrix +relationship: RO:0000052 GO:0031012 ! inheres in extracellular matrix [Term] id: OBA:0005792 @@ -155681,8 +255036,8 @@ synonym: "morphology of mouth floor" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003679 ! mouth floor -relationship: inheres_in UBERON:0003679 ! mouth floor +intersection_of: RO:0000052 UBERON:0003679 ! inheres in mouth floor +relationship: RO:0000052 UBERON:0003679 ! inheres in mouth floor [Term] id: OBA:0005793 @@ -155692,7 +255047,7 @@ synonym: "morphology of frenulum of tongue" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000514 ! frenulum of tongue quality is_a: OBA:VT0003745 ! mouth mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006689 ! frenulum of tongue +intersection_of: RO:0000052 UBERON:0006689 ! inheres in frenulum of tongue [Term] id: OBA:0005794 @@ -155701,8 +255056,8 @@ def: "The morphology of a pharyngeal pouch 4." [AUTO:patterns/patterns/entity_at synonym: "morphology of pharyngeal pouch 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006031 ! branchial pouch morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007125 ! pharyngeal pouch 4 -relationship: inheres_in UBERON:0007125 ! pharyngeal pouch 4 +intersection_of: RO:0000052 UBERON:0007125 ! inheres in pharyngeal pouch 4 +relationship: RO:0000052 UBERON:0007125 ! inheres in pharyngeal pouch 4 [Term] id: OBA:0005795 @@ -155712,8 +255067,8 @@ synonym: "amount of pharyngeal pouch 4" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0007125 ! pharyngeal pouch 4 -relationship: inheres_in UBERON:0007125 ! pharyngeal pouch 4 +intersection_of: RO:0000052 UBERON:0007125 ! inheres in pharyngeal pouch 4 +relationship: RO:0000052 UBERON:0007125 ! inheres in pharyngeal pouch 4 [Term] id: OBA:0005796 @@ -155723,7 +255078,7 @@ synonym: "size of pharyngeal arch 3" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003881 ! pharyngeal arch size is_a: OBA:0004230 ! pharyngeal arch 3 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003114 ! pharyngeal arch 3 +intersection_of: RO:0000052 UBERON:0003114 ! inheres in pharyngeal arch 3 [Term] id: OBA:0005797 @@ -155733,7 +255088,7 @@ synonym: "size of pharyngeal arch 4" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003881 ! pharyngeal arch size is_a: OBA:0004236 ! pharyngeal arch 4 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003115 ! pharyngeal arch 4 +intersection_of: RO:0000052 UBERON:0003115 ! inheres in pharyngeal arch 4 [Term] id: OBA:0005798 @@ -155743,7 +255098,7 @@ synonym: "size of pharyngeal arch 6" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003881 ! pharyngeal arch size is_a: OBA:0004231 ! pharyngeal arch 6 morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003117 ! pharyngeal arch 6 +intersection_of: RO:0000052 UBERON:0003117 ! inheres in pharyngeal arch 6 [Term] id: OBA:0005799 @@ -155753,8 +255108,8 @@ synonym: "amount of T cell mediated cytotoxicity" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0010139 ! immune response trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0001913 ! T cell mediated cytotoxicity -relationship: inheres_in GO:0001913 ! T cell mediated cytotoxicity +intersection_of: RO:0000052 GO:0001913 ! inheres in T cell mediated cytotoxicity +relationship: RO:0000052 GO:0001913 ! inheres in T cell mediated cytotoxicity [Term] id: OBA:0005800 @@ -155764,8 +255119,8 @@ synonym: "onset quality of acrosome reaction" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0007340 ! acrosome reaction -relationship: inheres_in GO:0007340 ! acrosome reaction +intersection_of: RO:0000052 GO:0007340 ! inheres in acrosome reaction +relationship: RO:0000052 GO:0007340 ! inheres in acrosome reaction [Term] id: OBA:0005801 @@ -155775,7 +255130,7 @@ synonym: "displaced of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005976 ! pancreas position is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:0005802 @@ -155784,8 +255139,8 @@ def: "The functionality of a submandibular gland." [AUTO:patterns/patterns/entit synonym: "functionality of submandibular gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005852 ! major salivary gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001736 ! submandibular gland -relationship: inheres_in UBERON:0001736 ! submandibular gland +intersection_of: RO:0000052 UBERON:0001736 ! inheres in submandibular gland +relationship: RO:0000052 UBERON:0001736 ! inheres in submandibular gland [Term] id: OBA:0005803 @@ -155795,8 +255150,8 @@ synonym: "morphology of tela choroidea" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005283 ! tela choroidea -relationship: inheres_in UBERON:0005283 ! tela choroidea +intersection_of: RO:0000052 UBERON:0005283 ! inheres in tela choroidea +relationship: RO:0000052 UBERON:0005283 ! inheres in tela choroidea [Term] id: OBA:0005804 @@ -155806,8 +255161,8 @@ synonym: "morphology of capsule of ovary" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001307 ! capsule of ovary -relationship: inheres_in UBERON:0001307 ! capsule of ovary +intersection_of: RO:0000052 UBERON:0001307 ! inheres in capsule of ovary +relationship: RO:0000052 UBERON:0001307 ! inheres in capsule of ovary [Term] id: OBA:0005805 @@ -155817,8 +255172,8 @@ synonym: "amount of capsule of ovary" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001307 ! capsule of ovary -relationship: inheres_in UBERON:0001307 ! capsule of ovary +intersection_of: RO:0000052 UBERON:0001307 ! inheres in capsule of ovary +relationship: RO:0000052 UBERON:0001307 ! inheres in capsule of ovary [Term] id: OBA:0005806 @@ -155828,7 +255183,7 @@ synonym: "size of female preputial gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0005572 ! female preputial gland morphology is_a: OBA:VT0002716 ! preputial gland size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005302 ! female preputial gland +intersection_of: RO:0000052 UBERON:0005302 ! inheres in female preputial gland [Term] id: OBA:0005807 @@ -155837,8 +255192,8 @@ def: "The morphology of a ampullary gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of ampullary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005809 ! male reproductive gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009645 ! ampullary gland -relationship: inheres_in UBERON:0009645 ! ampullary gland +intersection_of: RO:0000052 UBERON:0009645 ! inheres in ampullary gland +relationship: RO:0000052 UBERON:0009645 ! inheres in ampullary gland [Term] id: OBA:0005808 @@ -155847,8 +255202,8 @@ def: "The morphology of a female reproductive gland." [AUTO:patterns/patterns/en synonym: "morphology of female reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000653 ! sex gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005398 ! female reproductive gland -relationship: inheres_in UBERON:0005398 ! female reproductive gland +intersection_of: RO:0000052 UBERON:0005398 ! inheres in female reproductive gland +relationship: RO:0000052 UBERON:0005398 ! inheres in female reproductive gland [Term] id: OBA:0005809 @@ -155857,8 +255212,8 @@ def: "The morphology of a male reproductive gland." [AUTO:patterns/patterns/enti synonym: "morphology of male reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000653 ! sex gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005399 ! male reproductive gland -relationship: inheres_in UBERON:0005399 ! male reproductive gland +intersection_of: RO:0000052 UBERON:0005399 ! inheres in male reproductive gland +relationship: RO:0000052 UBERON:0005399 ! inheres in male reproductive gland [Term] id: OBA:0005810 @@ -155867,8 +255222,8 @@ def: "The functionality of a female reproductive gland." [AUTO:patterns/patterns synonym: "functionality of female reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005647 ! sex gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005398 ! female reproductive gland -relationship: inheres_in UBERON:0005398 ! female reproductive gland +intersection_of: RO:0000052 UBERON:0005398 ! inheres in female reproductive gland +relationship: RO:0000052 UBERON:0005398 ! inheres in female reproductive gland [Term] id: OBA:0005811 @@ -155877,8 +255232,8 @@ def: "The functionality of a male reproductive gland." [AUTO:patterns/patterns/e synonym: "functionality of male reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005647 ! sex gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0005399 ! male reproductive gland -relationship: inheres_in UBERON:0005399 ! male reproductive gland +intersection_of: RO:0000052 UBERON:0005399 ! inheres in male reproductive gland +relationship: RO:0000052 UBERON:0005399 ! inheres in male reproductive gland [Term] id: OBA:0005812 @@ -155887,8 +255242,8 @@ def: "The size of a abdominal viscera." [AUTO:patterns/patterns/entity_attribute synonym: "size of abdominal viscera" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0017672 ! abdominal viscera -relationship: inheres_in UBERON:0017672 ! abdominal viscera +intersection_of: RO:0000052 UBERON:0017672 ! inheres in abdominal viscera +relationship: RO:0000052 UBERON:0017672 ! inheres in abdominal viscera [Term] id: OBA:0005813 @@ -155897,18 +255252,19 @@ def: "The morphology of a male accessory sex gland." [AUTO:patterns/patterns/ent synonym: "morphology of male accessory sex gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005809 ! male reproductive gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010147 ! male accessory sex gland -relationship: inheres_in UBERON:0010147 ! male accessory sex gland +intersection_of: RO:0000052 UBERON:0010147 ! inheres in male accessory sex gland +relationship: RO:0000052 UBERON:0010147 ! inheres in male accessory sex gland [Term] id: OBA:0005814 name: pituicyte morphology def: "The morphology of a pituicyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of pituicyte" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:VT0002181 ! brain cell morphology trait is_a: OBA:VT0002182 ! astrocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000645 ! pituicyte -relationship: inheres_in CL:0000645 ! pituicyte +intersection_of: RO:0000052 CL:0000645 ! inheres in pituicyte +relationship: RO:0000052 CL:0000645 ! inheres in pituicyte [Term] id: OBA:0005815 @@ -155917,8 +255273,8 @@ def: "The morphology of a folliculostellate cell." [AUTO:patterns/patterns/entit synonym: "morphology of folliculostellate cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000642 ! folliculostellate cell -relationship: inheres_in CL:0000642 ! folliculostellate cell +intersection_of: RO:0000052 CL:0000642 ! inheres in folliculostellate cell +relationship: RO:0000052 CL:0000642 ! inheres in folliculostellate cell [Term] id: OBA:0005816 @@ -155928,7 +255284,7 @@ synonym: "branchiness of Rathke's pouch" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0003817 ! Rathke's pouch morphology trait is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0005356 ! Rathke's pouch +intersection_of: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch [Term] id: OBA:0005817 @@ -155938,7 +255294,7 @@ synonym: "size of Rathke's pouch" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000172 ! tube size is_a: OBA:VT0003817 ! Rathke's pouch morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005356 ! Rathke's pouch +intersection_of: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch [Term] id: OBA:0005818 @@ -155948,17 +255304,17 @@ synonym: "displaced of pituitary gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000518 ! pituitary gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:0005819 name: pinealocyte morphology def: "The morphology of a pinealocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of pinealocyte" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1001065 ! cell morphology +is_a: OBA:VT0002181 ! brain cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000652 ! pinealocyte -relationship: inheres_in CL:0000652 ! pinealocyte +intersection_of: RO:0000052 CL:0000652 ! inheres in pinealocyte +relationship: RO:0000052 CL:0000652 ! inheres in pinealocyte [Term] id: OBA:0005820 @@ -155968,8 +255324,8 @@ synonym: "amount of pineal body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001905 ! pineal body -relationship: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body +relationship: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:0005821 @@ -155979,8 +255335,8 @@ synonym: "functionality of sweat gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0005150 ! integumentary adnexa functionality is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001820 ! sweat gland -relationship: inheres_in UBERON:0001820 ! sweat gland +intersection_of: RO:0000052 UBERON:0001820 ! inheres in sweat gland +relationship: RO:0000052 UBERON:0001820 ! inheres in sweat gland [Term] id: OBA:0005822 @@ -155989,8 +255345,8 @@ def: "The morphology of a acinar cell of sebaceous gland." [AUTO:patterns/patter synonym: "morphology of acinar cell of sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002140 ! acinar cell of sebaceous gland -relationship: inheres_in CL:0002140 ! acinar cell of sebaceous gland +intersection_of: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland +relationship: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland [Term] id: OBA:0005823 @@ -156000,8 +255356,8 @@ synonym: "amount of acinar cell of sebaceous gland" EXACT [AUTO:patterns/pattern is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002140 ! acinar cell of sebaceous gland -relationship: inheres_in CL:0002140 ! acinar cell of sebaceous gland +intersection_of: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland +relationship: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland [Term] id: OBA:0005824 @@ -156010,8 +255366,8 @@ def: "The morphology of a perianal sebaceous gland." [AUTO:patterns/patterns/ent synonym: "morphology of perianal sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000647 ! sebaceous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012281 ! perianal sebaceous gland -relationship: inheres_in UBERON:0012281 ! perianal sebaceous gland +intersection_of: RO:0000052 UBERON:0012281 ! inheres in perianal sebaceous gland +relationship: RO:0000052 UBERON:0012281 ! inheres in perianal sebaceous gland [Term] id: OBA:0005825 @@ -156021,7 +255377,7 @@ synonym: "size of perianal sebaceous gland" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0005824 ! perianal sebaceous gland morphology is_a: OBA:VT0000652 ! sebaceous gland size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012281 ! perianal sebaceous gland +intersection_of: RO:0000052 UBERON:0012281 ! inheres in perianal sebaceous gland [Term] id: OBA:0005826 @@ -156030,8 +255386,8 @@ def: "The functionality of a tarsal gland." [AUTO:patterns/patterns/entity_attri synonym: "functionality of tarsal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002991 ! sebaceous gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001818 ! tarsal gland -relationship: inheres_in UBERON:0001818 ! tarsal gland +intersection_of: RO:0000052 UBERON:0001818 ! inheres in tarsal gland +relationship: RO:0000052 UBERON:0001818 ! inheres in tarsal gland [Term] id: OBA:0005827 @@ -156041,8 +255397,8 @@ synonym: "morphology of palpebral conjunctiva" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001812 ! palpebral conjunctiva -relationship: inheres_in UBERON:0001812 ! palpebral conjunctiva +intersection_of: RO:0000052 UBERON:0001812 ! inheres in palpebral conjunctiva +relationship: RO:0000052 UBERON:0001812 ! inheres in palpebral conjunctiva [Term] id: OBA:0005828 @@ -156051,8 +255407,8 @@ def: "The morphology of a gland of Zeis." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of gland of Zeis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004769 ! skin sebaceous gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0018233 ! gland of Zeis -relationship: inheres_in UBERON:0018233 ! gland of Zeis +intersection_of: RO:0000052 UBERON:0018233 ! inheres in gland of Zeis +relationship: RO:0000052 UBERON:0018233 ! inheres in gland of Zeis [Term] id: OBA:0005829 @@ -156062,8 +255418,8 @@ synonym: "morphology of bulbar conjunctiva" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010306 ! bulbar conjunctiva -relationship: inheres_in UBERON:0010306 ! bulbar conjunctiva +intersection_of: RO:0000052 UBERON:0010306 ! inheres in bulbar conjunctiva +relationship: RO:0000052 UBERON:0010306 ! inheres in bulbar conjunctiva [Term] id: OBA:0005830 @@ -156072,8 +255428,8 @@ def: "The morphology of a dendritic epidermal T cell." [AUTO:patterns/patterns/e synonym: "morphology of dendritic epidermal T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008344 ! mature gamma-delta T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000916 ! dendritic epidermal T cell -relationship: inheres_in CL:0000916 ! dendritic epidermal T cell +intersection_of: RO:0000052 CL:0000916 ! inheres in dendritic epidermal T cell +relationship: RO:0000052 CL:0000916 ! inheres in dendritic epidermal T cell [Term] id: OBA:0005831 @@ -156082,8 +255438,8 @@ def: "The amount of a dendritic epidermal T cell." [AUTO:patterns/patterns/entit synonym: "amount of dendritic epidermal T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004382 ! mature gamma-delta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000916 ! dendritic epidermal T cell -relationship: inheres_in CL:0000916 ! dendritic epidermal T cell +intersection_of: RO:0000052 CL:0000916 ! inheres in dendritic epidermal T cell +relationship: RO:0000052 CL:0000916 ! inheres in dendritic epidermal T cell [Term] id: OBA:0005832 @@ -156092,8 +255448,8 @@ def: "The amount of a naive thymus-derived CD8-positive, alpha-beta T cell." [AU synonym: "amount of naive thymus-derived CD8-positive, alpha-beta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004295 ! CD8-positive, alpha-beta T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell -relationship: inheres_in CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell +intersection_of: RO:0000052 CL:0000900 ! inheres in naive thymus-derived CD8-positive, alpha-beta T cell +relationship: RO:0000052 CL:0000900 ! inheres in naive thymus-derived CD8-positive, alpha-beta T cell [Term] id: OBA:0005833 @@ -156103,7 +255459,7 @@ synonym: "size of Harderian gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005248 ! Harderian gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004187 ! Harderian gland +intersection_of: RO:0000052 UBERON:0004187 ! inheres in Harderian gland [Term] id: OBA:0005834 @@ -156113,8 +255469,8 @@ synonym: "functionality of lacrimal apparatus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001750 ! lacrimal apparatus -relationship: inheres_in UBERON:0001750 ! lacrimal apparatus +intersection_of: RO:0000052 UBERON:0001750 ! inheres in lacrimal apparatus +relationship: RO:0000052 UBERON:0001750 ! inheres in lacrimal apparatus [Term] id: OBA:0005835 @@ -156124,7 +255480,7 @@ synonym: "closure of nasolacrimal duct" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004549 ! nasolacrimal duct morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0002392 ! nasolacrimal duct +intersection_of: RO:0000052 UBERON:0002392 ! inheres in nasolacrimal duct [Term] id: OBA:0005836 @@ -156133,8 +255489,8 @@ def: "The amount of a eccrine sweat gland." [AUTO:patterns/patterns/entity_attri synonym: "amount of eccrine sweat gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002776 ! sweat gland amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000423 ! eccrine sweat gland -relationship: inheres_in UBERON:0000423 ! eccrine sweat gland +intersection_of: RO:0000052 UBERON:0000423 ! inheres in eccrine sweat gland +relationship: RO:0000052 UBERON:0000423 ! inheres in eccrine sweat gland [Term] id: OBA:0005837 @@ -156144,8 +255500,8 @@ synonym: "morphology of conjunctival fornix" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010307 ! conjunctival fornix -relationship: inheres_in UBERON:0010307 ! conjunctival fornix +intersection_of: RO:0000052 UBERON:0010307 ! inheres in conjunctival fornix +relationship: RO:0000052 UBERON:0010307 ! inheres in conjunctival fornix [Term] id: OBA:0005838 @@ -156155,8 +255511,8 @@ synonym: "morphology of corneo-scleral junction" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006761 ! corneo-scleral junction -relationship: inheres_in UBERON:0006761 ! corneo-scleral junction +intersection_of: RO:0000052 UBERON:0006761 ! inheres in corneo-scleral junction +relationship: RO:0000052 UBERON:0006761 ! inheres in corneo-scleral junction [Term] id: OBA:0005839 @@ -156165,8 +255521,8 @@ def: "The morphology of a crypt of Lieberkuhn of ileum." [AUTO:patterns/patterns synonym: "morphology of crypt of Lieberkuhn of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004076 ! crypt of Lieberkuhn of small intestine morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013481 ! crypt of Lieberkuhn of ileum -relationship: inheres_in UBERON:0013481 ! crypt of Lieberkuhn of ileum +intersection_of: RO:0000052 UBERON:0013481 ! inheres in crypt of Lieberkuhn of ileum +relationship: RO:0000052 UBERON:0013481 ! inheres in crypt of Lieberkuhn of ileum [Term] id: OBA:0005840 @@ -156175,8 +255531,8 @@ def: "The morphology of a crypt of Lieberkuhn of duodenum." [AUTO:patterns/patte synonym: "morphology of crypt of Lieberkuhn of duodenum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004076 ! crypt of Lieberkuhn of small intestine morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013482 ! crypt of Lieberkuhn of duodenum -relationship: inheres_in UBERON:0013482 ! crypt of Lieberkuhn of duodenum +intersection_of: RO:0000052 UBERON:0013482 ! inheres in crypt of Lieberkuhn of duodenum +relationship: RO:0000052 UBERON:0013482 ! inheres in crypt of Lieberkuhn of duodenum [Term] id: OBA:0005841 @@ -156185,8 +255541,8 @@ def: "The morphology of a crypt of Lieberkuhn of jejunum." [AUTO:patterns/patter synonym: "morphology of crypt of Lieberkuhn of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004076 ! crypt of Lieberkuhn of small intestine morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013483 ! crypt of Lieberkuhn of jejunum -relationship: inheres_in UBERON:0013483 ! crypt of Lieberkuhn of jejunum +intersection_of: RO:0000052 UBERON:0013483 ! inheres in crypt of Lieberkuhn of jejunum +relationship: RO:0000052 UBERON:0013483 ! inheres in crypt of Lieberkuhn of jejunum [Term] id: OBA:0005842 @@ -156196,8 +255552,8 @@ synonym: "amount of paneth cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000510 ! paneth cell -relationship: inheres_in CL:0000510 ! paneth cell +intersection_of: RO:0000052 CL:0000510 ! inheres in paneth cell +relationship: RO:0000052 CL:0000510 ! inheres in paneth cell [Term] id: OBA:0005843 @@ -156206,8 +255562,8 @@ def: "The functionality of a paneth cell." [AUTO:patterns/patterns/entity_attrib synonym: "functionality of paneth cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000510 ! paneth cell -relationship: inheres_in CL:0000510 ! paneth cell +intersection_of: RO:0000052 CL:0000510 ! inheres in paneth cell +relationship: RO:0000052 CL:0000510 ! inheres in paneth cell [Term] id: OBA:0005844 @@ -156216,8 +255572,8 @@ def: "The morphology of a infundibular recess of 3rd ventricle." [AUTO:patterns/ synonym: "morphology of infundibular recess of 3rd ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006250 ! infundibular recess of 3rd ventricle -relationship: inheres_in UBERON:0006250 ! infundibular recess of 3rd ventricle +intersection_of: RO:0000052 UBERON:0006250 ! inheres in infundibular recess of 3rd ventricle +relationship: RO:0000052 UBERON:0006250 ! inheres in infundibular recess of 3rd ventricle [Term] id: OBA:0005845 @@ -156227,8 +255583,8 @@ synonym: "amount of infundibular recess of 3rd ventricle" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006250 ! infundibular recess of 3rd ventricle -relationship: inheres_in UBERON:0006250 ! infundibular recess of 3rd ventricle +intersection_of: RO:0000052 UBERON:0006250 ! inheres in infundibular recess of 3rd ventricle +relationship: RO:0000052 UBERON:0006250 ! inheres in infundibular recess of 3rd ventricle [Term] id: OBA:0005846 @@ -156238,8 +255594,8 @@ synonym: "morphology of submucosa of trachea" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002202 ! submucosa of trachea -relationship: inheres_in UBERON:0002202 ! submucosa of trachea +intersection_of: RO:0000052 UBERON:0002202 ! inheres in submucosa of trachea +relationship: RO:0000052 UBERON:0002202 ! inheres in submucosa of trachea [Term] id: OBA:0005847 @@ -156248,8 +255604,8 @@ def: "The morphology of a trachea gland." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of trachea gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0006000 ! submucosal gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005203 ! trachea gland -relationship: inheres_in UBERON:0005203 ! trachea gland +intersection_of: RO:0000052 UBERON:0005203 ! inheres in trachea gland +relationship: RO:0000052 UBERON:0005203 ! inheres in trachea gland [Term] id: OBA:0005848 @@ -156259,8 +255615,8 @@ synonym: "amount of trachea gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005203 ! trachea gland -relationship: inheres_in UBERON:0005203 ! trachea gland +intersection_of: RO:0000052 UBERON:0005203 ! inheres in trachea gland +relationship: RO:0000052 UBERON:0005203 ! inheres in trachea gland [Term] id: OBA:0005849 @@ -156270,7 +255626,7 @@ synonym: "closure of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002282 ! trachea morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:0005850 @@ -156280,8 +255636,8 @@ synonym: "morphology of periderm" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003055 ! periderm -relationship: inheres_in UBERON:0003055 ! periderm +intersection_of: RO:0000052 UBERON:0003055 ! inheres in periderm +relationship: RO:0000052 UBERON:0003055 ! inheres in periderm [Term] id: OBA:0005851 @@ -156290,8 +255646,8 @@ def: "The functionality of a parotid gland." [AUTO:patterns/patterns/entity_attr synonym: "functionality of parotid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005852 ! major salivary gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001831 ! parotid gland -relationship: inheres_in UBERON:0001831 ! parotid gland +intersection_of: RO:0000052 UBERON:0001831 ! inheres in parotid gland +relationship: RO:0000052 UBERON:0001831 ! inheres in parotid gland [Term] id: OBA:0005852 @@ -156300,8 +255656,8 @@ def: "The functionality of a major salivary gland." [AUTO:patterns/patterns/enti synonym: "functionality of major salivary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005310 ! salivary gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001829 ! major salivary gland -relationship: inheres_in UBERON:0001829 ! major salivary gland +intersection_of: RO:0000052 UBERON:0001829 ! inheres in major salivary gland +relationship: RO:0000052 UBERON:0001829 ! inheres in major salivary gland [Term] id: OBA:0005853 @@ -156310,8 +255666,8 @@ def: "The functionality of a minor salivary gland." [AUTO:patterns/patterns/enti synonym: "functionality of minor salivary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005310 ! salivary gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001830 ! minor salivary gland -relationship: inheres_in UBERON:0001830 ! minor salivary gland +intersection_of: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland +relationship: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland [Term] id: OBA:0005854 @@ -156320,8 +255676,8 @@ def: "The functionality of a sublingual gland." [AUTO:patterns/patterns/entity_a synonym: "functionality of sublingual gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005852 ! major salivary gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001832 ! sublingual gland -relationship: inheres_in UBERON:0001832 ! sublingual gland +intersection_of: RO:0000052 UBERON:0001832 ! inheres in sublingual gland +relationship: RO:0000052 UBERON:0001832 ! inheres in sublingual gland [Term] id: OBA:0005855 @@ -156330,8 +255686,8 @@ def: "The morphology of a holocrine gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of holocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012344 ! holocrine gland -relationship: inheres_in UBERON:0012344 ! holocrine gland +intersection_of: RO:0000052 UBERON:0012344 ! inheres in holocrine gland +relationship: RO:0000052 UBERON:0012344 ! inheres in holocrine gland [Term] id: OBA:0005856 @@ -156340,8 +255696,8 @@ def: "The morphology of a merocrine gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of merocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010243 ! merocrine gland -relationship: inheres_in UBERON:0010243 ! merocrine gland +intersection_of: RO:0000052 UBERON:0010243 ! inheres in merocrine gland +relationship: RO:0000052 UBERON:0010243 ! inheres in merocrine gland [Term] id: OBA:0005857 @@ -156350,8 +255706,8 @@ def: "The rate of a cerebellar granule cell precursor proliferation." [AUTO:patt synonym: "rate of cerebellar granule cell precursor proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0021930 ! cerebellar granule cell precursor proliferation -relationship: inheres_in GO:0021930 ! cerebellar granule cell precursor proliferation +intersection_of: RO:0000052 GO:0021930 ! inheres in cerebellar granule cell precursor proliferation +relationship: RO:0000052 GO:0021930 ! inheres in cerebellar granule cell precursor proliferation [Term] id: OBA:0005858 @@ -156360,8 +255716,8 @@ def: "The morphology of a apocrine gland." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of apocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008974 ! apocrine gland -relationship: inheres_in UBERON:0008974 ! apocrine gland +intersection_of: RO:0000052 UBERON:0008974 ! inheres in apocrine gland +relationship: RO:0000052 UBERON:0008974 ! inheres in apocrine gland [Term] id: OBA:0005859 @@ -156370,8 +255726,8 @@ def: "The functionality of a apocrine gland." [AUTO:patterns/patterns/entity_att synonym: "functionality of apocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0008974 ! apocrine gland -relationship: inheres_in UBERON:0008974 ! apocrine gland +intersection_of: RO:0000052 UBERON:0008974 ! inheres in apocrine gland +relationship: RO:0000052 UBERON:0008974 ! inheres in apocrine gland [Term] id: OBA:0005860 @@ -156380,8 +255736,8 @@ def: "The functionality of a holocrine gland." [AUTO:patterns/patterns/entity_at synonym: "functionality of holocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0012344 ! holocrine gland -relationship: inheres_in UBERON:0012344 ! holocrine gland +intersection_of: RO:0000052 UBERON:0012344 ! inheres in holocrine gland +relationship: RO:0000052 UBERON:0012344 ! inheres in holocrine gland [Term] id: OBA:0005861 @@ -156390,8 +255746,8 @@ def: "The functionality of a merocrine gland." [AUTO:patterns/patterns/entity_at synonym: "functionality of merocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0010243 ! merocrine gland -relationship: inheres_in UBERON:0010243 ! merocrine gland +intersection_of: RO:0000052 UBERON:0010243 ! inheres in merocrine gland +relationship: RO:0000052 UBERON:0010243 ! inheres in merocrine gland [Term] id: OBA:0005862 @@ -156400,8 +255756,8 @@ def: "The morphology of a exocrine gland." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of exocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002163 ! gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002365 ! exocrine gland -relationship: inheres_in UBERON:0002365 ! exocrine gland +intersection_of: RO:0000052 UBERON:0002365 ! inheres in exocrine gland +relationship: RO:0000052 UBERON:0002365 ! inheres in exocrine gland [Term] id: OBA:0005863 @@ -156410,8 +255766,8 @@ def: "The functionality of a exocrine gland." [AUTO:patterns/patterns/entity_att synonym: "functionality of exocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002164 ! gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002365 ! exocrine gland -relationship: inheres_in UBERON:0002365 ! exocrine gland +intersection_of: RO:0000052 UBERON:0002365 ! inheres in exocrine gland +relationship: RO:0000052 UBERON:0002365 ! inheres in exocrine gland [Term] id: OBA:0005864 @@ -156420,8 +255776,8 @@ def: "The morphology of a endocrine gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of endocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002163 ! gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002368 ! endocrine gland -relationship: inheres_in UBERON:0002368 ! endocrine gland +intersection_of: RO:0000052 UBERON:0002368 ! inheres in endocrine gland +relationship: RO:0000052 UBERON:0002368 ! inheres in endocrine gland [Term] id: OBA:0005865 @@ -156430,8 +255786,8 @@ def: "The functionality of a endocrine gland." [AUTO:patterns/patterns/entity_at synonym: "functionality of endocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002164 ! gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002368 ! endocrine gland -relationship: inheres_in UBERON:0002368 ! endocrine gland +intersection_of: RO:0000052 UBERON:0002368 ! inheres in endocrine gland +relationship: RO:0000052 UBERON:0002368 ! inheres in endocrine gland [Term] id: OBA:0005866 @@ -156441,8 +255797,8 @@ synonym: "morphology of circumventricular organ" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005408 ! circumventricular organ -relationship: inheres_in UBERON:0005408 ! circumventricular organ +intersection_of: RO:0000052 UBERON:0005408 ! inheres in circumventricular organ +relationship: RO:0000052 UBERON:0005408 ! inheres in circumventricular organ [Term] id: OBA:0005867 @@ -156452,8 +255808,8 @@ synonym: "morphology of secretory circumventricular organ" EXACT [AUTO:patterns/ is_a: OBA:0005866 ! circumventricular organ morphology is_a: OBA:VT0000631 ! neuroendocrine gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010134 ! secretory circumventricular organ -relationship: inheres_in UBERON:0010134 ! secretory circumventricular organ +intersection_of: RO:0000052 UBERON:0010134 ! inheres in secretory circumventricular organ +relationship: RO:0000052 UBERON:0010134 ! inheres in secretory circumventricular organ [Term] id: OBA:0005868 @@ -156462,8 +255818,8 @@ def: "The morphology of a sensory circumventricular organ." [AUTO:patterns/patte synonym: "morphology of sensory circumventricular organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005866 ! circumventricular organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010135 ! sensory circumventricular organ -relationship: inheres_in UBERON:0010135 ! sensory circumventricular organ +intersection_of: RO:0000052 UBERON:0010135 ! inheres in sensory circumventricular organ +relationship: RO:0000052 UBERON:0010135 ! inheres in sensory circumventricular organ [Term] id: OBA:0005869 @@ -156473,8 +255829,8 @@ synonym: "morphology of adrenal gland capsule" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002052 ! adrenal gland capsule -relationship: inheres_in UBERON:0002052 ! adrenal gland capsule +intersection_of: RO:0000052 UBERON:0002052 ! inheres in adrenal gland capsule +relationship: RO:0000052 UBERON:0002052 ! inheres in adrenal gland capsule [Term] id: OBA:0005870 @@ -156484,7 +255840,7 @@ synonym: "size of gastric gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003892 ! gastric gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000325 ! gastric gland +intersection_of: RO:0000052 UBERON:0000325 ! inheres in gastric gland [Term] id: OBA:0005871 @@ -156494,7 +255850,7 @@ synonym: "degeneration of gastric gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0003892 ! gastric gland morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000325 ! gastric gland +intersection_of: RO:0000052 UBERON:0000325 ! inheres in gastric gland [Term] id: OBA:0005872 @@ -156503,8 +255859,8 @@ def: "The functionality of a neuroendocrine gland." [AUTO:patterns/patterns/enti synonym: "functionality of neuroendocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005865 ! endocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0010133 ! neuroendocrine gland -relationship: inheres_in UBERON:0010133 ! neuroendocrine gland +intersection_of: RO:0000052 UBERON:0010133 ! inheres in neuroendocrine gland +relationship: RO:0000052 UBERON:0010133 ! inheres in neuroendocrine gland [Term] id: OBA:0005873 @@ -156514,8 +255870,8 @@ synonym: "morphology of capsule of parathyroid gland" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001748 ! capsule of parathyroid gland -relationship: inheres_in UBERON:0001748 ! capsule of parathyroid gland +intersection_of: RO:0000052 UBERON:0001748 ! inheres in capsule of parathyroid gland +relationship: RO:0000052 UBERON:0001748 ! inheres in capsule of parathyroid gland [Term] id: OBA:0005874 @@ -156525,8 +255881,8 @@ synonym: "displaced of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000057 ! gland quality is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland -relationship: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland +relationship: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:0005875 @@ -156536,8 +255892,8 @@ synonym: "morphology of forestomach-glandular stomach junction" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012270 ! forestomach-glandular stomach junction -relationship: inheres_in UBERON:0012270 ! forestomach-glandular stomach junction +intersection_of: RO:0000052 UBERON:0012270 ! inheres in forestomach-glandular stomach junction +relationship: RO:0000052 UBERON:0012270 ! inheres in forestomach-glandular stomach junction [Term] id: OBA:0005876 @@ -156547,7 +255903,7 @@ synonym: "size of murine forestomach" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005197 ! murine forestomach morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008827 ! murine forestomach +intersection_of: RO:0000052 UBERON:0008827 ! inheres in murine forestomach [Term] id: OBA:0005877 @@ -156557,8 +255913,8 @@ synonym: "morphology of stomach glandular region" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011953 ! stomach glandular region -relationship: inheres_in UBERON:0011953 ! stomach glandular region +intersection_of: RO:0000052 UBERON:0011953 ! inheres in stomach glandular region +relationship: RO:0000052 UBERON:0011953 ! inheres in stomach glandular region [Term] id: OBA:0005878 @@ -156567,8 +255923,8 @@ def: "The morphology of a gland of nasal mucosa." [AUTO:patterns/patterns/entity synonym: "morphology of gland of nasal mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012278 ! gland of nasal mucosa -relationship: inheres_in UBERON:0012278 ! gland of nasal mucosa +intersection_of: RO:0000052 UBERON:0012278 ! inheres in gland of nasal mucosa +relationship: RO:0000052 UBERON:0012278 ! inheres in gland of nasal mucosa [Term] id: OBA:0005879 @@ -156578,7 +255934,7 @@ synonym: "degeneration of gland of nasal mucosa" EXACT [AUTO:patterns/patterns/e is_a: OBA:0005878 ! gland of nasal mucosa morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0012278 ! gland of nasal mucosa +intersection_of: RO:0000052 UBERON:0012278 ! inheres in gland of nasal mucosa [Term] id: OBA:0005880 @@ -156588,7 +255944,7 @@ synonym: "degeneration of saliva-secreting gland" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0000613 ! salivary gland morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001044 ! saliva-secreting gland +intersection_of: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland [Term] id: OBA:0005881 @@ -156598,7 +255954,7 @@ synonym: "degeneration of pancreas" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002612 ! pancreas structure is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:0005882 @@ -156608,7 +255964,7 @@ synonym: "size of medulla of thymus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002375 ! thymus medulla morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002124 ! medulla of thymus +intersection_of: RO:0000052 UBERON:0002124 ! inheres in medulla of thymus [Term] id: OBA:0005883 @@ -156618,8 +255974,8 @@ synonym: "amount of medulla of thymus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002124 ! medulla of thymus -relationship: inheres_in UBERON:0002124 ! medulla of thymus +intersection_of: RO:0000052 UBERON:0002124 ! inheres in medulla of thymus +relationship: RO:0000052 UBERON:0002124 ! inheres in medulla of thymus [Term] id: OBA:0005884 @@ -156629,8 +255985,8 @@ synonym: "morphology of acinus of parotid gland" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011847 ! acinus of parotid gland -relationship: inheres_in UBERON:0011847 ! acinus of parotid gland +intersection_of: RO:0000052 UBERON:0011847 ! inheres in acinus of parotid gland +relationship: RO:0000052 UBERON:0011847 ! inheres in acinus of parotid gland [Term] id: OBA:0005885 @@ -156640,8 +255996,8 @@ synonym: "amount of vomeronasal organ" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002255 ! vomeronasal organ -relationship: inheres_in UBERON:0002255 ! vomeronasal organ +intersection_of: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ +relationship: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ [Term] id: OBA:0005886 @@ -156651,8 +256007,8 @@ synonym: "functionality of vomeronasal organ" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002255 ! vomeronasal organ -relationship: inheres_in UBERON:0002255 ! vomeronasal organ +intersection_of: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ +relationship: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ [Term] id: OBA:0005887 @@ -156662,7 +256018,7 @@ synonym: "size of vomeronasal organ" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002243 ! vomeronasal organ morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002255 ! vomeronasal organ +intersection_of: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ [Term] id: OBA:0005888 @@ -156673,7 +256029,7 @@ is_a: OBA:0002016 ! gonad structure is_a: OBA:VT0001146 ! testes morphology trait is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:0005889 @@ -156682,8 +256038,8 @@ def: "The morphology of a ovarian bursa." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of ovarian bursa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010684 ! peritoneum morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012333 ! ovarian bursa -relationship: inheres_in UBERON:0012333 ! ovarian bursa +intersection_of: RO:0000052 UBERON:0012333 ! inheres in ovarian bursa +relationship: RO:0000052 UBERON:0012333 ! inheres in ovarian bursa [Term] id: OBA:0005890 @@ -156693,8 +256049,8 @@ synonym: "morphology of ovarian fossa" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0016883 ! ovarian fossa -relationship: inheres_in UBERON:0016883 ! ovarian fossa +intersection_of: RO:0000052 UBERON:0016883 ! inheres in ovarian fossa +relationship: RO:0000052 UBERON:0016883 ! inheres in ovarian fossa [Term] id: OBA:0005891 @@ -156704,8 +256060,8 @@ synonym: "morphology of ovarian cortex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013191 ! ovarian cortex -relationship: inheres_in UBERON:0013191 ! ovarian cortex +intersection_of: RO:0000052 UBERON:0013191 ! inheres in ovarian cortex +relationship: RO:0000052 UBERON:0013191 ! inheres in ovarian cortex [Term] id: OBA:0005892 @@ -156715,8 +256071,8 @@ synonym: "morphology of ovarian medulla" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013192 ! ovarian medulla -relationship: inheres_in UBERON:0013192 ! ovarian medulla +intersection_of: RO:0000052 UBERON:0013192 ! inheres in ovarian medulla +relationship: RO:0000052 UBERON:0013192 ! inheres in ovarian medulla [Term] id: OBA:0005893 @@ -156726,8 +256082,8 @@ synonym: "morphology of rete ovarii" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010185 ! rete ovarii -relationship: inheres_in UBERON:0010185 ! rete ovarii +intersection_of: RO:0000052 UBERON:0010185 ! inheres in rete ovarii +relationship: RO:0000052 UBERON:0010185 ! inheres in rete ovarii [Term] id: OBA:0005894 @@ -156737,8 +256093,8 @@ synonym: "morphology of bile duct epithelium" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004820 ! bile duct epithelium -relationship: inheres_in UBERON:0004820 ! bile duct epithelium +intersection_of: RO:0000052 UBERON:0004820 ! inheres in bile duct epithelium +relationship: RO:0000052 UBERON:0004820 ! inheres in bile duct epithelium [Term] id: OBA:0005895 @@ -156747,8 +256103,8 @@ def: "The morphology of a hematopoietic cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of hematopoietic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000988 ! hematopoietic cell -relationship: inheres_in CL:0000988 ! hematopoietic cell +intersection_of: RO:0000052 CL:0000988 ! inheres in hematopoietic cell +relationship: RO:0000052 CL:0000988 ! inheres in hematopoietic cell [Term] id: OBA:0005896 @@ -156757,8 +256113,8 @@ def: "The morphology of a myeloid cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of myeloid cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005895 ! hematopoietic cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000763 ! myeloid cell -relationship: inheres_in CL:0000763 ! myeloid cell +intersection_of: RO:0000052 CL:0000763 ! inheres in myeloid cell +relationship: RO:0000052 CL:0000763 ! inheres in myeloid cell [Term] id: OBA:0005897 @@ -156767,8 +256123,8 @@ def: "The morphology of a erythroid lineage cell." [AUTO:patterns/patterns/entit synonym: "morphology of erythroid lineage cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005896 ! myeloid cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000764 ! erythroid lineage cell -relationship: inheres_in CL:0000764 ! erythroid lineage cell +intersection_of: RO:0000052 CL:0000764 ! inheres in erythroid lineage cell +relationship: RO:0000052 CL:0000764 ! inheres in erythroid lineage cell [Term] id: OBA:0005898 @@ -156778,8 +256134,8 @@ synonym: "morphology of bone marrow hematopoietic cell" EXACT [AUTO:patterns/pat is_a: OBA:0005895 ! hematopoietic cell morphology is_a: OBA:VT0002398 ! bone marrow cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001610 ! bone marrow hematopoietic cell -relationship: inheres_in CL:1001610 ! bone marrow hematopoietic cell +intersection_of: RO:0000052 CL:1001610 ! inheres in bone marrow hematopoietic cell +relationship: RO:0000052 CL:1001610 ! inheres in bone marrow hematopoietic cell [Term] id: OBA:0005899 @@ -156788,8 +256144,8 @@ def: "The amount of a myeloid cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of myeloid cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005333 ! hematopoietic cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000763 ! myeloid cell -relationship: inheres_in CL:0000763 ! myeloid cell +intersection_of: RO:0000052 CL:0000763 ! inheres in myeloid cell +relationship: RO:0000052 CL:0000763 ! inheres in myeloid cell [Term] id: OBA:0005900 @@ -156798,8 +256154,8 @@ def: "The amount of a immature natural killer cell." [AUTO:patterns/patterns/ent synonym: "amount of immature natural killer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003353 ! natural killer cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000823 ! immature natural killer cell -relationship: inheres_in CL:0000823 ! immature natural killer cell +intersection_of: RO:0000052 CL:0000823 ! inheres in immature natural killer cell +relationship: RO:0000052 CL:0000823 ! inheres in immature natural killer cell [Term] id: OBA:0005901 @@ -156808,8 +256164,8 @@ def: "The amount of a mature natural killer cell." [AUTO:patterns/patterns/entit synonym: "amount of mature natural killer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003353 ! natural killer cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000824 ! mature natural killer cell -relationship: inheres_in CL:0000824 ! mature natural killer cell +intersection_of: RO:0000052 CL:0000824 ! inheres in mature natural killer cell +relationship: RO:0000052 CL:0000824 ! inheres in mature natural killer cell [Term] id: OBA:0005902 @@ -156820,8 +256176,8 @@ is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:0005898 ! bone marrow hematopoietic cell morphology is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000557 ! granulocyte monocyte progenitor cell -relationship: inheres_in CL:0000557 ! granulocyte monocyte progenitor cell +intersection_of: RO:0000052 CL:0000557 ! inheres in granulocyte monocyte progenitor cell +relationship: RO:0000052 CL:0000557 ! inheres in granulocyte monocyte progenitor cell [Term] id: OBA:0005903 @@ -156832,8 +256188,8 @@ is_a: OBA:0003458 ! bone marrow cell amount is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000557 ! granulocyte monocyte progenitor cell -relationship: inheres_in CL:0000557 ! granulocyte monocyte progenitor cell +intersection_of: RO:0000052 CL:0000557 ! inheres in granulocyte monocyte progenitor cell +relationship: RO:0000052 CL:0000557 ! inheres in granulocyte monocyte progenitor cell [Term] id: OBA:0005904 @@ -156842,8 +256198,8 @@ def: "The morphology of a immature natural killer cell." [AUTO:patterns/patterns synonym: "morphology of immature natural killer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005068 ! NK cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000823 ! immature natural killer cell -relationship: inheres_in CL:0000823 ! immature natural killer cell +intersection_of: RO:0000052 CL:0000823 ! inheres in immature natural killer cell +relationship: RO:0000052 CL:0000823 ! inheres in immature natural killer cell [Term] id: OBA:0005905 @@ -156852,8 +256208,8 @@ def: "The morphology of a mature natural killer cell." [AUTO:patterns/patterns/e synonym: "morphology of mature natural killer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005068 ! NK cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000824 ! mature natural killer cell -relationship: inheres_in CL:0000824 ! mature natural killer cell +intersection_of: RO:0000052 CL:0000824 ! inheres in mature natural killer cell +relationship: RO:0000052 CL:0000824 ! inheres in mature natural killer cell [Term] id: OBA:0005906 @@ -156863,8 +256219,8 @@ synonym: "morphology of megakaryocyte-erythroid progenitor cell" EXACT [AUTO:pat is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000050 ! megakaryocyte-erythroid progenitor cell -relationship: inheres_in CL:0000050 ! megakaryocyte-erythroid progenitor cell +intersection_of: RO:0000052 CL:0000050 ! inheres in megakaryocyte-erythroid progenitor cell +relationship: RO:0000052 CL:0000050 ! inheres in megakaryocyte-erythroid progenitor cell [Term] id: OBA:0005907 @@ -156874,8 +256230,8 @@ synonym: "amount of megakaryocyte-erythroid progenitor cell" EXACT [AUTO:pattern is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000050 ! megakaryocyte-erythroid progenitor cell -relationship: inheres_in CL:0000050 ! megakaryocyte-erythroid progenitor cell +intersection_of: RO:0000052 CL:0000050 ! inheres in megakaryocyte-erythroid progenitor cell +relationship: RO:0000052 CL:0000050 ! inheres in megakaryocyte-erythroid progenitor cell [Term] id: OBA:0005908 @@ -156884,8 +256240,8 @@ def: "The morphology of a hematopoietic precursor cell." [AUTO:patterns/patterns synonym: "morphology of hematopoietic precursor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005895 ! hematopoietic cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0008001 ! hematopoietic precursor cell -relationship: inheres_in CL:0008001 ! hematopoietic precursor cell +intersection_of: RO:0000052 CL:0008001 ! inheres in hematopoietic precursor cell +relationship: RO:0000052 CL:0008001 ! inheres in hematopoietic precursor cell [Term] id: OBA:0005909 @@ -156894,8 +256250,8 @@ def: "The amount of a hematopoietic precursor cell." [AUTO:patterns/patterns/ent synonym: "amount of hematopoietic precursor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005333 ! hematopoietic cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0008001 ! hematopoietic precursor cell -relationship: inheres_in CL:0008001 ! hematopoietic precursor cell +intersection_of: RO:0000052 CL:0008001 ! inheres in hematopoietic precursor cell +relationship: RO:0000052 CL:0008001 ! inheres in hematopoietic precursor cell [Term] id: OBA:0005910 @@ -156904,8 +256260,8 @@ def: "The morphology of a cervical mammary gland." [AUTO:patterns/patterns/entit synonym: "morphology of cervical mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000627 ! mammary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005199 ! cervical mammary gland -relationship: inheres_in UBERON:0005199 ! cervical mammary gland +intersection_of: RO:0000052 UBERON:0005199 ! inheres in cervical mammary gland +relationship: RO:0000052 UBERON:0005199 ! inheres in cervical mammary gland [Term] id: OBA:0005911 @@ -156914,8 +256270,8 @@ def: "The morphology of a abdominal mammary gland." [AUTO:patterns/patterns/enti synonym: "morphology of abdominal mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000627 ! mammary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003488 ! abdominal mammary gland -relationship: inheres_in UBERON:0003488 ! abdominal mammary gland +intersection_of: RO:0000052 UBERON:0003488 ! inheres in abdominal mammary gland +relationship: RO:0000052 UBERON:0003488 ! inheres in abdominal mammary gland [Term] id: OBA:0005912 @@ -156924,8 +256280,8 @@ def: "The morphology of a inguinal mammary gland." [AUTO:patterns/patterns/entit synonym: "morphology of inguinal mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000627 ! mammary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008424 ! inguinal mammary gland -relationship: inheres_in UBERON:0008424 ! inguinal mammary gland +intersection_of: RO:0000052 UBERON:0008424 ! inheres in inguinal mammary gland +relationship: RO:0000052 UBERON:0008424 ! inheres in inguinal mammary gland [Term] id: OBA:0005913 @@ -156934,8 +256290,8 @@ def: "The morphology of a thoracic mammary gland." [AUTO:patterns/patterns/entit synonym: "morphology of thoracic mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000627 ! mammary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005200 ! thoracic mammary gland -relationship: inheres_in UBERON:0005200 ! thoracic mammary gland +intersection_of: RO:0000052 UBERON:0005200 ! inheres in thoracic mammary gland +relationship: RO:0000052 UBERON:0005200 ! inheres in thoracic mammary gland [Term] id: OBA:0005914 @@ -156945,7 +256301,7 @@ synonym: "amount of milk ejection reflex" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0002202 ! reflex amount is_a: OBA:1000807 ! milk ejection reflex quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0060156 ! milk ejection reflex +intersection_of: RO:0000052 GO:0060156 ! inheres in milk ejection reflex [Term] id: OBA:0005915 @@ -156955,8 +256311,8 @@ synonym: "color saturation of mammary gland" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000057 ! gland quality is_a: PATO:0000017 ! color saturation intersection_of: PATO:0000017 ! color saturation -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:0005916 @@ -156966,8 +256322,8 @@ synonym: "morphology of mammary ridge" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008425 ! mammary ridge -relationship: inheres_in UBERON:0008425 ! mammary ridge +intersection_of: RO:0000052 UBERON:0008425 ! inheres in mammary ridge +relationship: RO:0000052 UBERON:0008425 ! inheres in mammary ridge [Term] id: OBA:0005917 @@ -156977,8 +256333,8 @@ synonym: "morphology of mammary placode" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005311 ! mammary placode -relationship: inheres_in UBERON:0005311 ! mammary placode +intersection_of: RO:0000052 UBERON:0005311 ! inheres in mammary placode +relationship: RO:0000052 UBERON:0005311 ! inheres in mammary placode [Term] id: OBA:0005918 @@ -156987,8 +256343,8 @@ def: "The morphology of a mammary gland cord." [AUTO:patterns/patterns/entity_at synonym: "morphology of mammary gland cord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004750 ! epithelium of mammary gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004182 ! mammary gland cord -relationship: inheres_in UBERON:0004182 ! mammary gland cord +intersection_of: RO:0000052 UBERON:0004182 ! inheres in mammary gland cord +relationship: RO:0000052 UBERON:0004182 ! inheres in mammary gland cord [Term] id: OBA:0005919 @@ -156997,8 +256353,8 @@ def: "The morphology of a nipple sheath." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of nipple sheath" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001216 ! epidermis morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005083 ! nipple sheath -relationship: inheres_in UBERON:0005083 ! nipple sheath +intersection_of: RO:0000052 UBERON:0005083 ! inheres in nipple sheath +relationship: RO:0000052 UBERON:0005083 ! inheres in nipple sheath [Term] id: OBA:0005920 @@ -157008,8 +256364,8 @@ synonym: "amount of nipple sheath" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005083 ! nipple sheath -relationship: inheres_in UBERON:0005083 ! nipple sheath +intersection_of: RO:0000052 UBERON:0005083 ! inheres in nipple sheath +relationship: RO:0000052 UBERON:0005083 ! inheres in nipple sheath [Term] id: OBA:0005921 @@ -157019,8 +256375,8 @@ synonym: "morphology of tunica albuginea of testis" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006643 ! tunica albuginea of testis -relationship: inheres_in UBERON:0006643 ! tunica albuginea of testis +intersection_of: RO:0000052 UBERON:0006643 ! inheres in tunica albuginea of testis +relationship: RO:0000052 UBERON:0006643 ! inheres in tunica albuginea of testis [Term] id: OBA:0005922 @@ -157030,8 +256386,8 @@ synonym: "morphology of tunica vaginalis testis" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006650 ! tunica vaginalis testis -relationship: inheres_in UBERON:0006650 ! tunica vaginalis testis +intersection_of: RO:0000052 UBERON:0006650 ! inheres in tunica vaginalis testis +relationship: RO:0000052 UBERON:0006650 ! inheres in tunica vaginalis testis [Term] id: OBA:0005923 @@ -157041,8 +256397,8 @@ synonym: "morphology of conjunctival sac" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005908 ! conjunctival sac -relationship: inheres_in UBERON:0005908 ! conjunctival sac +intersection_of: RO:0000052 UBERON:0005908 ! inheres in conjunctival sac +relationship: RO:0000052 UBERON:0005908 ! inheres in conjunctival sac [Term] id: OBA:0005924 @@ -157052,8 +256408,8 @@ synonym: "morphology of margin of eyelid" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0034772 ! margin of eyelid -relationship: inheres_in UBERON:0034772 ! margin of eyelid +intersection_of: RO:0000052 UBERON:0034772 ! inheres in margin of eyelid +relationship: RO:0000052 UBERON:0034772 ! inheres in margin of eyelid [Term] id: OBA:0005925 @@ -157063,8 +256419,8 @@ synonym: "elasticity of trachea cartilage" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001031 ! elasticity intersection_of: PATO:0001031 ! elasticity -intersection_of: inheres_in UBERON:0003604 ! trachea cartilage -relationship: inheres_in UBERON:0003604 ! trachea cartilage +intersection_of: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage +relationship: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage [Term] id: OBA:0005926 @@ -157074,8 +256430,8 @@ synonym: "morphology of ocular surface region" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010409 ! ocular surface region -relationship: inheres_in UBERON:0010409 ! ocular surface region +intersection_of: RO:0000052 UBERON:0010409 ! inheres in ocular surface region +relationship: RO:0000052 UBERON:0010409 ! inheres in ocular surface region [Term] id: OBA:0005927 @@ -157085,8 +256441,8 @@ synonym: "rate of intestinal phytosterol absorption" EXACT [AUTO:patterns/patter is_a: OBA:1000642 ! intestinal absorption quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060752 ! intestinal phytosterol absorption -relationship: inheres_in GO:0060752 ! intestinal phytosterol absorption +intersection_of: RO:0000052 GO:0060752 ! inheres in intestinal phytosterol absorption +relationship: RO:0000052 GO:0060752 ! inheres in intestinal phytosterol absorption [Term] id: OBA:0005928 @@ -157096,8 +256452,8 @@ synonym: "rate of intestinal D-glucose absorption" EXACT [AUTO:patterns/patterns is_a: OBA:1000642 ! intestinal absorption quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0001951 ! intestinal D-glucose absorption -relationship: inheres_in GO:0001951 ! intestinal D-glucose absorption +intersection_of: RO:0000052 GO:0001951 ! inheres in intestinal D-glucose absorption +relationship: RO:0000052 GO:0001951 ! inheres in intestinal D-glucose absorption [Term] id: OBA:0005929 @@ -157106,8 +256462,8 @@ def: "The morphology of a helper T cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of helper T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002435 ! effector T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000912 ! helper T cell -relationship: inheres_in CL:0000912 ! helper T cell +intersection_of: RO:0000052 CL:0000912 ! inheres in helper T cell +relationship: RO:0000052 CL:0000912 ! inheres in helper T cell [Term] id: OBA:0005930 @@ -157116,8 +256472,8 @@ def: "The amount of a effector T cell." [AUTO:patterns/patterns/entity_attribute synonym: "amount of effector T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002636 ! T cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000911 ! effector T cell -relationship: inheres_in CL:0000911 ! effector T cell +intersection_of: RO:0000052 CL:0000911 ! inheres in effector T cell +relationship: RO:0000052 CL:0000911 ! inheres in effector T cell [Term] id: OBA:0005931 @@ -157127,8 +256483,8 @@ synonym: "amount of transverse palatine fold" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0008799 ! transverse palatine fold -relationship: inheres_in UBERON:0008799 ! transverse palatine fold +intersection_of: RO:0000052 UBERON:0008799 ! inheres in transverse palatine fold +relationship: RO:0000052 UBERON:0008799 ! inheres in transverse palatine fold [Term] id: OBA:0005932 @@ -157138,8 +256494,8 @@ synonym: "amount of bone marrow development" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0048539 ! bone marrow development -relationship: inheres_in GO:0048539 ! bone marrow development +intersection_of: RO:0000052 GO:0048539 ! inheres in bone marrow development +relationship: RO:0000052 GO:0048539 ! inheres in bone marrow development [Term] id: OBA:0005933 @@ -157148,8 +256504,8 @@ def: "The morphology of a mammary gland myoepithelium." [AUTO:patterns/patterns/ synonym: "morphology of mammary gland myoepithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004750 ! epithelium of mammary gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006954 ! mammary gland myoepithelium -relationship: inheres_in UBERON:0006954 ! mammary gland myoepithelium +intersection_of: RO:0000052 UBERON:0006954 ! inheres in mammary gland myoepithelium +relationship: RO:0000052 UBERON:0006954 ! inheres in mammary gland myoepithelium [Term] id: OBA:0005934 @@ -157158,8 +256514,8 @@ def: "The functionality of a mammary gland myoepithelium." [AUTO:patterns/patter synonym: "functionality of mammary gland myoepithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005011 ! epithelium of mammary gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0006954 ! mammary gland myoepithelium -relationship: inheres_in UBERON:0006954 ! mammary gland myoepithelium +intersection_of: RO:0000052 UBERON:0006954 ! inheres in mammary gland myoepithelium +relationship: RO:0000052 UBERON:0006954 ! inheres in mammary gland myoepithelium [Term] id: OBA:0005935 @@ -157169,8 +256525,8 @@ synonym: "morphology of mammary gland luminal epithelium" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011950 ! mammary gland luminal epithelium -relationship: inheres_in UBERON:0011950 ! mammary gland luminal epithelium +intersection_of: RO:0000052 UBERON:0011950 ! inheres in mammary gland luminal epithelium +relationship: RO:0000052 UBERON:0011950 ! inheres in mammary gland luminal epithelium [Term] id: OBA:0005936 @@ -157179,8 +256535,8 @@ def: "The morphology of a mammary duct terminal end bud." [AUTO:patterns/pattern synonym: "morphology of mammary duct terminal end bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004750 ! epithelium of mammary gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005313 ! mammary duct terminal end bud -relationship: inheres_in UBERON:0005313 ! mammary duct terminal end bud +intersection_of: RO:0000052 UBERON:0005313 ! inheres in mammary duct terminal end bud +relationship: RO:0000052 UBERON:0005313 ! inheres in mammary duct terminal end bud [Term] id: OBA:0005937 @@ -157190,8 +256546,8 @@ synonym: "morphology of mammary bud" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005333 ! mammary bud -relationship: inheres_in UBERON:0005333 ! mammary bud +intersection_of: RO:0000052 UBERON:0005333 ! inheres in mammary bud +relationship: RO:0000052 UBERON:0005333 ! inheres in mammary bud [Term] id: OBA:0005938 @@ -157201,7 +256557,7 @@ synonym: "closure of external naris" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0002235 ! external nares morphology trait is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:0005939 @@ -157210,8 +256566,8 @@ def: "The morphology of a small intestine goblet cell." [AUTO:patterns/patterns/ synonym: "morphology of small intestine goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000495 ! small intestine goblet cell -relationship: inheres_in CL:1000495 ! small intestine goblet cell +intersection_of: RO:0000052 CL:1000495 ! inheres in small intestine goblet cell +relationship: RO:0000052 CL:1000495 ! inheres in small intestine goblet cell [Term] id: OBA:0005940 @@ -157220,8 +256576,8 @@ def: "The morphology of a large intestine goblet cell." [AUTO:patterns/patterns/ synonym: "morphology of large intestine goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000320 ! large intestine goblet cell -relationship: inheres_in CL:1000320 ! large intestine goblet cell +intersection_of: RO:0000052 CL:1000320 ! inheres in large intestine goblet cell +relationship: RO:0000052 CL:1000320 ! inheres in large intestine goblet cell [Term] id: OBA:0005941 @@ -157230,8 +256586,8 @@ def: "The morphology of a intestinal villus goblet cell." [AUTO:patterns/pattern synonym: "morphology of intestinal villus goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005939 ! small intestine goblet cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000317 ! intestinal villus goblet cell -relationship: inheres_in CL:1000317 ! intestinal villus goblet cell +intersection_of: RO:0000052 CL:1000317 ! inheres in intestinal villus goblet cell +relationship: RO:0000052 CL:1000317 ! inheres in intestinal villus goblet cell [Term] id: OBA:0005942 @@ -157240,8 +256596,8 @@ def: "The morphology of a duodenal goblet cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of duodenal goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005941 ! intestinal villus goblet cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000324 ! duodenal goblet cell -relationship: inheres_in CL:1000324 ! duodenal goblet cell +intersection_of: RO:0000052 CL:1000324 ! inheres in duodenal goblet cell +relationship: RO:0000052 CL:1000324 ! inheres in duodenal goblet cell [Term] id: OBA:0005943 @@ -157250,8 +256606,8 @@ def: "The morphology of a ileal goblet cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of ileal goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005941 ! intestinal villus goblet cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000326 ! ileal goblet cell -relationship: inheres_in CL:1000326 ! ileal goblet cell +intersection_of: RO:0000052 CL:1000326 ! inheres in ileal goblet cell +relationship: RO:0000052 CL:1000326 ! inheres in ileal goblet cell [Term] id: OBA:0005944 @@ -157260,8 +256616,8 @@ def: "The morphology of a jejunal goblet cell." [AUTO:patterns/patterns/entity_a synonym: "morphology of jejunal goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005941 ! intestinal villus goblet cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000325 ! jejunal goblet cell -relationship: inheres_in CL:1000325 ! jejunal goblet cell +intersection_of: RO:0000052 CL:1000325 ! inheres in jejunal goblet cell +relationship: RO:0000052 CL:1000325 ! inheres in jejunal goblet cell [Term] id: OBA:0005945 @@ -157271,8 +256627,8 @@ synonym: "amount of pectinate muscle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005980 ! pectinate muscle -relationship: inheres_in UBERON:0005980 ! pectinate muscle +intersection_of: RO:0000052 UBERON:0005980 ! inheres in pectinate muscle +relationship: RO:0000052 UBERON:0005980 ! inheres in pectinate muscle [Term] id: OBA:0005946 @@ -157282,8 +256638,8 @@ synonym: "amount of brachiocephalic artery" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001529 ! brachiocephalic artery -relationship: inheres_in UBERON:0001529 ! brachiocephalic artery +intersection_of: RO:0000052 UBERON:0001529 ! inheres in brachiocephalic artery +relationship: RO:0000052 UBERON:0001529 ! inheres in brachiocephalic artery [Term] id: OBA:0005947 @@ -157293,7 +256649,7 @@ synonym: "size of hepatic portal vein" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000032 ! blood vessel size is_a: OBA:0005145 ! hepatic portal vein morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001639 ! hepatic portal vein +intersection_of: RO:0000052 UBERON:0001639 ! inheres in hepatic portal vein [Term] id: OBA:0005948 @@ -157303,7 +256659,7 @@ synonym: "amount of nasal cavity" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000277 ! nasal cavity quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001707 ! nasal cavity +intersection_of: RO:0000052 UBERON:0001707 ! inheres in nasal cavity [Term] id: OBA:0005949 @@ -157313,8 +256669,8 @@ synonym: "morphology of oral cavity" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000167 ! oral cavity -relationship: inheres_in UBERON:0000167 ! oral cavity +intersection_of: RO:0000052 UBERON:0000167 ! inheres in oral cavity +relationship: RO:0000052 UBERON:0000167 ! inheres in oral cavity [Term] id: OBA:0005950 @@ -157324,8 +256680,8 @@ synonym: "morphology of acromioclavicular joint" EXACT [AUTO:patterns/patterns/e is_a: OBA:0003754 ! skeletal joint morphology is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003692 ! acromioclavicular joint -relationship: inheres_in UBERON:0003692 ! acromioclavicular joint +intersection_of: RO:0000052 UBERON:0003692 ! inheres in acromioclavicular joint +relationship: RO:0000052 UBERON:0003692 ! inheres in acromioclavicular joint [Term] id: OBA:0005951 @@ -157335,8 +256691,8 @@ synonym: "amount of optic cup" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003072 ! optic cup -relationship: inheres_in UBERON:0003072 ! optic cup +intersection_of: RO:0000052 UBERON:0003072 ! inheres in optic cup +relationship: RO:0000052 UBERON:0003072 ! inheres in optic cup [Term] id: OBA:0005952 @@ -157346,7 +256702,7 @@ synonym: "morphology of cerebral artery" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005507 ! systemic artery morphology is_a: OBA:1000168 ! cerebral artery quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004449 ! cerebral artery +intersection_of: RO:0000052 UBERON:0004449 ! inheres in cerebral artery [Term] id: OBA:0005953 @@ -157356,8 +256712,8 @@ synonym: "morphology of hypoglossal canal" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006682 ! hypoglossal canal -relationship: inheres_in UBERON:0006682 ! hypoglossal canal +intersection_of: RO:0000052 UBERON:0006682 ! inheres in hypoglossal canal +relationship: RO:0000052 UBERON:0006682 ! inheres in hypoglossal canal [Term] id: OBA:0005954 @@ -157367,7 +256723,7 @@ synonym: "size of hypoglossal canal" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0005953 ! hypoglossal canal morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006682 ! hypoglossal canal +intersection_of: RO:0000052 UBERON:0006682 ! inheres in hypoglossal canal [Term] id: OBA:0005955 @@ -157377,8 +256733,8 @@ synonym: "amount of hypoglossal canal" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006682 ! hypoglossal canal -relationship: inheres_in UBERON:0006682 ! hypoglossal canal +intersection_of: RO:0000052 UBERON:0006682 ! inheres in hypoglossal canal +relationship: RO:0000052 UBERON:0006682 ! inheres in hypoglossal canal [Term] id: OBA:0005956 @@ -157388,7 +256744,7 @@ synonym: "size of facial nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001071 ! facial nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001647 ! facial nerve +intersection_of: RO:0000052 UBERON:0001647 ! inheres in facial nerve [Term] id: OBA:0005957 @@ -157398,7 +256754,7 @@ synonym: "size of splanchnic nerve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003316 ! nerve size is_a: OBA:0004366 ! splanchnic nerve morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003715 ! splanchnic nerve +intersection_of: RO:0000052 UBERON:0003715 ! inheres in splanchnic nerve [Term] id: OBA:0005958 @@ -157408,8 +256764,8 @@ synonym: "position of vagus nerve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000471 ! nerve quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001759 ! vagus nerve -relationship: inheres_in UBERON:0001759 ! vagus nerve +intersection_of: RO:0000052 UBERON:0001759 ! inheres in vagus nerve +relationship: RO:0000052 UBERON:0001759 ! inheres in vagus nerve [Term] id: OBA:0005959 @@ -157419,7 +256775,7 @@ synonym: "curvature of vagus nerve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0001074 ! vagus nerve morphology trait is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001759 ! vagus nerve +intersection_of: RO:0000052 UBERON:0001759 ! inheres in vagus nerve [Term] id: OBA:0005960 @@ -157429,7 +256785,7 @@ synonym: "size of vagus nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001074 ! vagus nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001759 ! vagus nerve +intersection_of: RO:0000052 UBERON:0001759 ! inheres in vagus nerve [Term] id: OBA:0005961 @@ -157439,7 +256795,7 @@ synonym: "size of hypoglossal nerve" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001076 ! hypoglossal nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001650 ! hypoglossal nerve +intersection_of: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve [Term] id: OBA:0005962 @@ -157449,7 +256805,7 @@ synonym: "amount of hypoglossal nerve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000360 ! hypoglossal nerve quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001650 ! hypoglossal nerve +intersection_of: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve [Term] id: OBA:0005963 @@ -157459,7 +256815,7 @@ synonym: "position of hypoglossal nerve" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000360 ! hypoglossal nerve quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001650 ! hypoglossal nerve +intersection_of: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve [Term] id: OBA:0005964 @@ -157469,7 +256825,7 @@ synonym: "structure of ductus venosus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003463 ! blood vessel structure is_a: OBA:0005983 ! ductus venosus morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002083 ! ductus venosus +intersection_of: RO:0000052 UBERON:0002083 ! inheres in ductus venosus [Term] id: OBA:0005965 @@ -157479,7 +256835,7 @@ synonym: "structure of hepatic portal vein" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003463 ! blood vessel structure is_a: OBA:0005145 ! hepatic portal vein morphology intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0001639 ! hepatic portal vein +intersection_of: RO:0000052 UBERON:0001639 ! inheres in hepatic portal vein [Term] id: OBA:0005966 @@ -157489,8 +256845,8 @@ synonym: "position of eye muscle" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0004277 ! eye muscle -relationship: inheres_in UBERON:0004277 ! eye muscle +intersection_of: RO:0000052 UBERON:0004277 ! inheres in eye muscle +relationship: RO:0000052 UBERON:0004277 ! inheres in eye muscle [Term] id: OBA:0005967 @@ -157500,7 +256856,7 @@ synonym: "composition of hypodermis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0003705 ! hypodermis morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0002072 ! hypodermis +intersection_of: RO:0000052 UBERON:0002072 ! inheres in hypodermis [Term] id: OBA:0005968 @@ -157510,7 +256866,7 @@ synonym: "amount of abducens nerve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000548 ! abducens nerve quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001646 ! abducens nerve +intersection_of: RO:0000052 UBERON:0001646 ! inheres in abducens nerve [Term] id: OBA:0005969 @@ -157520,8 +256876,8 @@ synonym: "amount of posterior commissure" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0000936 ! posterior commissure -relationship: inheres_in UBERON:0000936 ! posterior commissure +intersection_of: RO:0000052 UBERON:0000936 ! inheres in posterior commissure +relationship: RO:0000052 UBERON:0000936 ! inheres in posterior commissure [Term] id: OBA:0005970 @@ -157531,8 +256887,8 @@ synonym: "position of mesonephric duct" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0003074 ! mesonephric duct -relationship: inheres_in UBERON:0003074 ! mesonephric duct +intersection_of: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct +relationship: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct [Term] id: OBA:0005971 @@ -157542,7 +256898,7 @@ synonym: "morphology of celiac artery" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0005507 ! systemic artery morphology is_a: OBA:1000176 ! celiac artery quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001640 ! celiac artery +intersection_of: RO:0000052 UBERON:0001640 ! inheres in celiac artery [Term] id: OBA:0005972 @@ -157552,7 +256908,7 @@ synonym: "amount of celiac artery" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000176 ! celiac artery quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001640 ! celiac artery +intersection_of: RO:0000052 UBERON:0001640 ! inheres in celiac artery [Term] id: OBA:0005973 @@ -157562,7 +256918,7 @@ synonym: "curvature of celiac artery" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0005971 ! celiac artery morphology is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001640 ! celiac artery +intersection_of: RO:0000052 UBERON:0001640 ! inheres in celiac artery [Term] id: OBA:0005974 @@ -157571,8 +256927,8 @@ def: "The morphology of a muscle of abdomen." [AUTO:patterns/patterns/entity_att synonym: "morphology of muscle of abdomen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002378 ! muscle of abdomen -relationship: inheres_in UBERON:0002378 ! muscle of abdomen +intersection_of: RO:0000052 UBERON:0002378 ! inheres in muscle of abdomen +relationship: RO:0000052 UBERON:0002378 ! inheres in muscle of abdomen [Term] id: OBA:0005975 @@ -157582,8 +256938,8 @@ synonym: "position of azygos vein" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000292 ! vein quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001594 ! azygos vein -relationship: inheres_in UBERON:0001594 ! azygos vein +intersection_of: RO:0000052 UBERON:0001594 ! inheres in azygos vein +relationship: RO:0000052 UBERON:0001594 ! inheres in azygos vein [Term] id: OBA:0005976 @@ -157593,8 +256949,8 @@ synonym: "position of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001264 ! pancreas -relationship: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas +relationship: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:0005977 @@ -157604,8 +256960,8 @@ synonym: "orientation of dorsal pancreatic bud" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0003923 ! dorsal pancreatic bud -relationship: inheres_in UBERON:0003923 ! dorsal pancreatic bud +intersection_of: RO:0000052 UBERON:0003923 ! inheres in dorsal pancreatic bud +relationship: RO:0000052 UBERON:0003923 ! inheres in dorsal pancreatic bud [Term] id: OBA:0005978 @@ -157614,8 +256970,8 @@ def: "The morphology of a dorsal pancreatic bud." [AUTO:patterns/patterns/entity synonym: "morphology of dorsal pancreatic bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003923 ! dorsal pancreatic bud -relationship: inheres_in UBERON:0003923 ! dorsal pancreatic bud +intersection_of: RO:0000052 UBERON:0003923 ! inheres in dorsal pancreatic bud +relationship: RO:0000052 UBERON:0003923 ! inheres in dorsal pancreatic bud [Term] id: OBA:0005979 @@ -157624,8 +256980,8 @@ def: "The morphology of a ventral pancreatic bud." [AUTO:patterns/patterns/entit synonym: "morphology of ventral pancreatic bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003924 ! ventral pancreatic bud -relationship: inheres_in UBERON:0003924 ! ventral pancreatic bud +intersection_of: RO:0000052 UBERON:0003924 ! inheres in ventral pancreatic bud +relationship: RO:0000052 UBERON:0003924 ! inheres in ventral pancreatic bud [Term] id: OBA:0005980 @@ -157635,8 +256991,8 @@ synonym: "orientation of ventral pancreatic bud" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0003924 ! ventral pancreatic bud -relationship: inheres_in UBERON:0003924 ! ventral pancreatic bud +intersection_of: RO:0000052 UBERON:0003924 ! inheres in ventral pancreatic bud +relationship: RO:0000052 UBERON:0003924 ! inheres in ventral pancreatic bud [Term] id: OBA:0005981 @@ -157646,8 +257002,8 @@ synonym: "position of stapedial artery" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000301 ! head blood vessel quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0006345 ! stapedial artery -relationship: inheres_in UBERON:0006345 ! stapedial artery +intersection_of: RO:0000052 UBERON:0006345 ! inheres in stapedial artery +relationship: RO:0000052 UBERON:0006345 ! inheres in stapedial artery [Term] id: OBA:0005982 @@ -157657,7 +257013,7 @@ synonym: "morphology of jugular vein" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000252 ! jugular vein quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004711 ! jugular vein +intersection_of: RO:0000052 UBERON:0004711 ! inheres in jugular vein [Term] id: OBA:0005983 @@ -157666,8 +257022,8 @@ def: "The morphology of a ductus venosus." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of ductus venosus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002083 ! ductus venosus -relationship: inheres_in UBERON:0002083 ! ductus venosus +intersection_of: RO:0000052 UBERON:0002083 ! inheres in ductus venosus +relationship: RO:0000052 UBERON:0002083 ! inheres in ductus venosus [Term] id: OBA:0005984 @@ -157677,8 +257033,8 @@ synonym: "position of ductus venosus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000292 ! vein quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002083 ! ductus venosus -relationship: inheres_in UBERON:0002083 ! ductus venosus +intersection_of: RO:0000052 UBERON:0002083 ! inheres in ductus venosus +relationship: RO:0000052 UBERON:0002083 ! inheres in ductus venosus [Term] id: OBA:0005985 @@ -157688,8 +257044,8 @@ synonym: "amount of ductus venosus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000292 ! vein quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002083 ! ductus venosus -relationship: inheres_in UBERON:0002083 ! ductus venosus +intersection_of: RO:0000052 UBERON:0002083 ! inheres in ductus venosus +relationship: RO:0000052 UBERON:0002083 ! inheres in ductus venosus [Term] id: OBA:0005986 @@ -157698,8 +257054,8 @@ def: "The amount of a common lymphoid progenitor." [AUTO:patterns/patterns/entit synonym: "amount of common lymphoid progenitor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005909 ! hematopoietic precursor cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000051 ! common lymphoid progenitor -relationship: inheres_in CL:0000051 ! common lymphoid progenitor +intersection_of: RO:0000052 CL:0000051 ! inheres in common lymphoid progenitor +relationship: RO:0000052 CL:0000051 ! inheres in common lymphoid progenitor [Term] id: OBA:0005987 @@ -157709,8 +257065,8 @@ synonym: "morphology of seminal vesicle epithelium" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004805 ! seminal vesicle epithelium -relationship: inheres_in UBERON:0004805 ! seminal vesicle epithelium +intersection_of: RO:0000052 UBERON:0004805 ! inheres in seminal vesicle epithelium +relationship: RO:0000052 UBERON:0004805 ! inheres in seminal vesicle epithelium [Term] id: OBA:0005988 @@ -157720,7 +257076,7 @@ synonym: "degeneration of seminal vesicle epithelium" EXACT [AUTO:patterns/patte is_a: OBA:0005987 ! seminal vesicle epithelium morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0004805 ! seminal vesicle epithelium +intersection_of: RO:0000052 UBERON:0004805 ! inheres in seminal vesicle epithelium [Term] id: OBA:0005989 @@ -157729,8 +257085,8 @@ def: "The amount of a female preputial gland." [AUTO:patterns/patterns/entity_at synonym: "amount of female preputial gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004256 ! preputial gland amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005302 ! female preputial gland -relationship: inheres_in UBERON:0005302 ! female preputial gland +intersection_of: RO:0000052 UBERON:0005302 ! inheres in female preputial gland +relationship: RO:0000052 UBERON:0005302 ! inheres in female preputial gland [Term] id: OBA:0005990 @@ -157739,8 +257095,8 @@ def: "The functionality of a seminal vesicle." [AUTO:patterns/patterns/entity_at synonym: "functionality of seminal vesicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005811 ! male reproductive gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000998 ! seminal vesicle -relationship: inheres_in UBERON:0000998 ! seminal vesicle +intersection_of: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle +relationship: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle [Term] id: OBA:0005991 @@ -157750,8 +257106,8 @@ synonym: "composition of seminal vesicle fluid" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0010143 ! seminal vesicle fluid -relationship: inheres_in UBERON:0010143 ! seminal vesicle fluid +intersection_of: RO:0000052 UBERON:0010143 ! inheres in seminal vesicle fluid +relationship: RO:0000052 UBERON:0010143 ! inheres in seminal vesicle fluid [Term] id: OBA:0005992 @@ -157761,8 +257117,8 @@ synonym: "morphology of muscular coat of seminal vesicle" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004665 ! muscular coat of seminal vesicle -relationship: inheres_in UBERON:0004665 ! muscular coat of seminal vesicle +intersection_of: RO:0000052 UBERON:0004665 ! inheres in muscular coat of seminal vesicle +relationship: RO:0000052 UBERON:0004665 ! inheres in muscular coat of seminal vesicle [Term] id: OBA:0005993 @@ -157772,8 +257128,8 @@ synonym: "position of endolymphatic sac" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002223 ! endolymphatic sac -relationship: inheres_in UBERON:0002223 ! endolymphatic sac +intersection_of: RO:0000052 UBERON:0002223 ! inheres in endolymphatic sac +relationship: RO:0000052 UBERON:0002223 ! inheres in endolymphatic sac [Term] id: OBA:0005994 @@ -157783,8 +257139,8 @@ synonym: "rate of response to electrical stimulus" EXACT [AUTO:patterns/patterns is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0051602 ! response to electrical stimulus -relationship: inheres_in GO:0051602 ! response to electrical stimulus +intersection_of: RO:0000052 GO:0051602 ! inheres in response to electrical stimulus +relationship: RO:0000052 GO:0051602 ! inheres in response to electrical stimulus [Term] id: OBA:0005995 @@ -157793,8 +257149,8 @@ def: "The morphology of a plasmablast." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of plasmablast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000980 ! plasmablast -relationship: inheres_in CL:0000980 ! plasmablast +intersection_of: RO:0000052 CL:0000980 ! inheres in plasmablast +relationship: RO:0000052 CL:0000980 ! inheres in plasmablast [Term] id: OBA:0005996 @@ -157803,8 +257159,8 @@ def: "The amount of a plasmablast." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of plasmablast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004324 ! mature B cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000980 ! plasmablast -relationship: inheres_in CL:0000980 ! plasmablast +intersection_of: RO:0000052 CL:0000980 ! inheres in plasmablast +relationship: RO:0000052 CL:0000980 ! inheres in plasmablast [Term] id: OBA:0005997 @@ -157814,8 +257170,8 @@ synonym: "morphology of peroxisome" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005777 ! peroxisome -relationship: inheres_in GO:0005777 ! peroxisome +intersection_of: RO:0000052 GO:0005777 ! inheres in peroxisome +relationship: RO:0000052 GO:0005777 ! inheres in peroxisome [Term] id: OBA:0005998 @@ -157824,8 +257180,8 @@ def: "The functionality of a mucous gland." [AUTO:patterns/patterns/entity_attri synonym: "functionality of mucous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000414 ! mucous gland -relationship: inheres_in UBERON:0000414 ! mucous gland +intersection_of: RO:0000052 UBERON:0000414 ! inheres in mucous gland +relationship: RO:0000052 UBERON:0000414 ! inheres in mucous gland [Term] id: OBA:0005999 @@ -157834,8 +257190,8 @@ def: "The functionality of a submucosal gland." [AUTO:patterns/patterns/entity_a synonym: "functionality of submucosal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005998 ! mucous gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0011148 ! submucosal gland -relationship: inheres_in UBERON:0011148 ! submucosal gland +intersection_of: RO:0000052 UBERON:0011148 ! inheres in submucosal gland +relationship: RO:0000052 UBERON:0011148 ! inheres in submucosal gland [Term] id: OBA:0006000 @@ -157844,8 +257200,8 @@ def: "The morphology of a submucosal gland." [AUTO:patterns/patterns/entity_attr synonym: "morphology of submucosal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011148 ! submucosal gland -relationship: inheres_in UBERON:0011148 ! submucosal gland +intersection_of: RO:0000052 UBERON:0011148 ! inheres in submucosal gland +relationship: RO:0000052 UBERON:0011148 ! inheres in submucosal gland [Term] id: OBA:0006001 @@ -157855,8 +257211,8 @@ synonym: "functionality of gut-associated lymphoid tissue" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001962 ! gut-associated lymphoid tissue -relationship: inheres_in UBERON:0001962 ! gut-associated lymphoid tissue +intersection_of: RO:0000052 UBERON:0001962 ! inheres in gut-associated lymphoid tissue +relationship: RO:0000052 UBERON:0001962 ! inheres in gut-associated lymphoid tissue [Term] id: OBA:0006002 @@ -157865,8 +257221,8 @@ def: "The functionality of a acinar cell of sebaceous gland." [AUTO:patterns/pat synonym: "functionality of acinar cell of sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0002140 ! acinar cell of sebaceous gland -relationship: inheres_in CL:0002140 ! acinar cell of sebaceous gland +intersection_of: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland +relationship: RO:0000052 CL:0002140 ! inheres in acinar cell of sebaceous gland [Term] id: OBA:0006003 @@ -157876,8 +257232,8 @@ synonym: "morphology of photoreceptor connecting cilium" EXACT [AUTO:patterns/pa is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0032391 ! photoreceptor connecting cilium -relationship: inheres_in GO:0032391 ! photoreceptor connecting cilium +intersection_of: RO:0000052 GO:0032391 ! inheres in photoreceptor connecting cilium +relationship: RO:0000052 GO:0032391 ! inheres in photoreceptor connecting cilium [Term] id: OBA:0006004 @@ -157887,8 +257243,8 @@ synonym: "displaced of paneth cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000076 ! attribute of cell is_a: PATO:0002181 ! displaced intersection_of: PATO:0002181 ! displaced -intersection_of: inheres_in CL:0000510 ! paneth cell -relationship: inheres_in CL:0000510 ! paneth cell +intersection_of: RO:0000052 CL:0000510 ! inheres in paneth cell +relationship: RO:0000052 CL:0000510 ! inheres in paneth cell [Term] id: OBA:0006005 @@ -157898,8 +257254,8 @@ synonym: "amount of intestinal villus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001213 ! intestinal villus -relationship: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus +relationship: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0006006 @@ -157909,7 +257265,7 @@ synonym: "branchiness of intestinal villus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0006009 ! intestinal villus shape is_a: PATO:0002009 ! branchiness intersection_of: PATO:0002009 ! branchiness -intersection_of: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0006007 @@ -157919,7 +257275,7 @@ synonym: "height of intestinal villus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003258 ! intestinal villus size is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0006008 @@ -157929,7 +257285,7 @@ synonym: "sharpness of intestinal villus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0006009 ! intestinal villus shape is_a: PATO:0000944 ! sharpness intersection_of: PATO:0000944 ! sharpness -intersection_of: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0006009 @@ -157939,7 +257295,7 @@ synonym: "shape of intestinal villus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0003257 ! intestinal villus morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001213 ! intestinal villus +intersection_of: RO:0000052 UBERON:0001213 ! inheres in intestinal villus [Term] id: OBA:0006010 @@ -157948,8 +257304,8 @@ def: "The rate of a chondrocyte proliferation." [AUTO:patterns/patterns/entity_a synonym: "rate of chondrocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003479 ! cell population proliferation rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0035988 ! chondrocyte proliferation -relationship: inheres_in GO:0035988 ! chondrocyte proliferation +intersection_of: RO:0000052 GO:0035988 ! inheres in chondrocyte proliferation +relationship: RO:0000052 GO:0035988 ! inheres in chondrocyte proliferation [Term] id: OBA:0006011 @@ -157958,8 +257314,8 @@ def: "The onset quality of a chondrocyte differentiation." [AUTO:patterns/patter synonym: "onset quality of chondrocyte differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002199 ! developmental process onset quality intersection_of: PATO:0002325 ! onset quality -intersection_of: inheres_in GO:0002062 ! chondrocyte differentiation -relationship: inheres_in GO:0002062 ! chondrocyte differentiation +intersection_of: RO:0000052 GO:0002062 ! inheres in chondrocyte differentiation +relationship: RO:0000052 GO:0002062 ! inheres in chondrocyte differentiation [Term] id: OBA:0006012 @@ -157969,7 +257325,7 @@ synonym: "size of ventral pancreatic bud" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000172 ! tube size is_a: OBA:0005979 ! ventral pancreatic bud morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003924 ! ventral pancreatic bud +intersection_of: RO:0000052 UBERON:0003924 ! inheres in ventral pancreatic bud [Term] id: OBA:0006013 @@ -157979,7 +257335,7 @@ synonym: "size of dorsal pancreatic bud" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0000172 ! tube size is_a: OBA:0005978 ! dorsal pancreatic bud morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003923 ! dorsal pancreatic bud +intersection_of: RO:0000052 UBERON:0003923 ! inheres in dorsal pancreatic bud [Term] id: OBA:0006014 @@ -157989,7 +257345,7 @@ synonym: "rate of phenylalanine decarboxylase activity" EXACT [AUTO:patterns/pat is_a: OBA:1000898 ! phenylalanine decarboxylase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0050174 ! phenylalanine decarboxylase activity +intersection_of: RO:0000052 GO:0050174 ! inheres in phenylalanine decarboxylase activity [Term] id: OBA:0006015 @@ -157999,7 +257355,7 @@ synonym: "rate of cholinesterase activity" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000658 ! cholinesterase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004104 ! cholinesterase activity +intersection_of: RO:0000052 GO:0004104 ! inheres in cholinesterase activity [Term] id: OBA:0006016 @@ -158009,7 +257365,7 @@ synonym: "rate of L-tyrosine aminotransferase activity" EXACT [AUTO:patterns/pat is_a: OBA:1000847 ! L-tyrosine aminotransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0070547 ! L-tyrosine aminotransferase activity +intersection_of: RO:0000052 GO:0070547 ! inheres in L-tyrosine aminotransferase activity [Term] id: OBA:0006017 @@ -158019,7 +257375,7 @@ synonym: "rate of procollagen-proline 4-dioxygenase activity" EXACT [AUTO:patter is_a: OBA:1000692 ! procollagen-proline 4-dioxygenase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004656 ! procollagen-proline 4-dioxygenase activity +intersection_of: RO:0000052 GO:0004656 ! inheres in procollagen-proline 4-dioxygenase activity [Term] id: OBA:0006018 @@ -158029,7 +257385,7 @@ synonym: "rate of thiopurine S-methyltransferase activity" EXACT [AUTO:patterns/ is_a: OBA:1000800 ! thiopurine S-methyltransferase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0008119 ! thiopurine S-methyltransferase activity +intersection_of: RO:0000052 GO:0008119 ! inheres in thiopurine S-methyltransferase activity [Term] id: OBA:0006019 @@ -158039,7 +257395,7 @@ synonym: "rate of tyrosine 3-monooxygenase activity" EXACT [AUTO:patterns/patter is_a: OBA:1000662 ! tyrosine 3-monooxygenase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004511 ! tyrosine 3-monooxygenase activity +intersection_of: RO:0000052 GO:0004511 ! inheres in tyrosine 3-monooxygenase activity [Term] id: OBA:0006020 @@ -158049,7 +257405,7 @@ synonym: "thickness of heart ventricle wall" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003468 ! heart ventricle wall size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0004784 ! heart ventricle wall +intersection_of: RO:0000052 UBERON:0004784 ! inheres in heart ventricle wall [Term] id: OBA:0006021 @@ -158059,7 +257415,7 @@ synonym: "thickness of interventricular septum" EXACT [AUTO:patterns/patterns/en is_a: OBA:0005169 ! interventricular septum size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:0006022 @@ -158069,7 +257425,7 @@ synonym: "size of adrenal gland X zone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004360 ! adrenal gland X zone morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0009024 ! adrenal gland X zone +intersection_of: RO:0000052 UBERON:0009024 ! inheres in adrenal gland X zone [Term] id: OBA:0006023 @@ -158079,7 +257435,7 @@ synonym: "rate of proline oxidase activity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000857 ! proline oxidase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0051699 ! proline oxidase activity +intersection_of: RO:0000052 GO:0051699 ! inheres in proline oxidase activity [Term] id: OBA:0006024 @@ -158089,7 +257445,7 @@ synonym: "degeneration of subcutaneous adipose tissue" EXACT [AUTO:patterns/patt is_a: OBA:0005324 ! subcutaneous adipose tissue morphology is_a: PATO:0002037 ! degeneration intersection_of: PATO:0002037 ! degeneration -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue [Term] id: OBA:0006025 @@ -158099,7 +257455,7 @@ synonym: "rate of pyruvate kinase activity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000728 ! pyruvate kinase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004743 ! pyruvate kinase activity +intersection_of: RO:0000052 GO:0004743 ! inheres in pyruvate kinase activity [Term] id: OBA:0006026 @@ -158109,8 +257465,8 @@ synonym: "amount of creatine kinase complex" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0002185 ! creatine kinase complex -relationship: inheres_in GO:0002185 ! creatine kinase complex +intersection_of: RO:0000052 GO:0002185 ! inheres in creatine kinase complex +relationship: RO:0000052 GO:0002185 ! inheres in creatine kinase complex [Term] id: OBA:0006027 @@ -158120,8 +257476,8 @@ synonym: "amount of limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002101 ! limb -relationship: inheres_in UBERON:0002101 ! limb +intersection_of: RO:0000052 UBERON:0002101 ! inheres in limb +relationship: RO:0000052 UBERON:0002101 ! inheres in limb [Term] id: OBA:0006028 @@ -158132,7 +257488,7 @@ is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0004136 ! tongue muscle morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000378 ! tongue muscle +intersection_of: RO:0000052 UBERON:0000378 ! inheres in tongue muscle [Term] id: OBA:0006029 @@ -158142,7 +257498,7 @@ synonym: "size of horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0006030 ! horn morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006967 ! horn +intersection_of: RO:0000052 UBERON:0006967 ! inheres in horn [Term] id: OBA:0006030 @@ -158152,8 +257508,8 @@ synonym: "morphology of horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006967 ! horn -relationship: inheres_in UBERON:0006967 ! horn +intersection_of: RO:0000052 UBERON:0006967 ! inheres in horn +relationship: RO:0000052 UBERON:0006967 ! inheres in horn [Term] id: OBA:0006031 @@ -158163,8 +257519,8 @@ synonym: "amount of horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006967 ! horn -relationship: inheres_in UBERON:0006967 ! horn +intersection_of: RO:0000052 UBERON:0006967 ! inheres in horn +relationship: RO:0000052 UBERON:0006967 ! inheres in horn [Term] id: OBA:0006032 @@ -158174,7 +257530,7 @@ synonym: "rate of creatine kinase activity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000667 ! creatine kinase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004111 ! creatine kinase activity +intersection_of: RO:0000052 GO:0004111 ! inheres in creatine kinase activity [Term] id: OBA:0006033 @@ -158184,7 +257540,7 @@ synonym: "rate of hydroxymethylbilane synthase activity" EXACT [AUTO:patterns/pa is_a: OBA:1000706 ! hydroxymethylbilane synthase activity quality is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0004418 ! hydroxymethylbilane synthase activity +intersection_of: RO:0000052 GO:0004418 ! inheres in hydroxymethylbilane synthase activity [Term] id: OBA:0006034 @@ -158193,8 +257549,8 @@ def: "The morphology of a gastrula." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of gastrula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001076 ! embryo morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004734 ! gastrula -relationship: inheres_in UBERON:0004734 ! gastrula +intersection_of: RO:0000052 UBERON:0004734 ! inheres in gastrula +relationship: RO:0000052 UBERON:0004734 ! inheres in gastrula [Term] id: OBA:0006035 @@ -158204,8 +257560,8 @@ synonym: "morphology of gustatory gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004285 ! serous gland morphology is_a: OBA:VT0000613 ! salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013475 ! gustatory gland -relationship: inheres_in UBERON:0013475 ! gustatory gland +intersection_of: RO:0000052 UBERON:0013475 ! inheres in gustatory gland +relationship: RO:0000052 UBERON:0013475 ! inheres in gustatory gland [Term] id: OBA:0006036 @@ -158214,8 +257570,8 @@ def: "The morphology of a nictitating membrane." [AUTO:patterns/patterns/entity_ synonym: "morphology of nictitating membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001340 ! eyelid morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010207 ! nictitating membrane -relationship: inheres_in UBERON:0010207 ! nictitating membrane +intersection_of: RO:0000052 UBERON:0010207 ! inheres in nictitating membrane +relationship: RO:0000052 UBERON:0010207 ! inheres in nictitating membrane [Term] id: OBA:0006037 @@ -158225,7 +257581,7 @@ synonym: "morphology of lacrimal sac" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000288 ! lacrimal sac quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001351 ! lacrimal sac +intersection_of: RO:0000052 UBERON:0001351 ! inheres in lacrimal sac [Term] id: OBA:0006038 @@ -158248,8 +257604,8 @@ def: "The morphology of a bone of reproductive organ." [AUTO:patterns/patterns/e synonym: "morphology of bone of reproductive organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007719 ! bone of reproductive organ -relationship: inheres_in UBERON:0007719 ! bone of reproductive organ +intersection_of: RO:0000052 UBERON:0007719 ! inheres in bone of reproductive organ +relationship: RO:0000052 UBERON:0007719 ! inheres in bone of reproductive organ [Term] id: OBA:0006102 @@ -158259,7 +257615,7 @@ synonym: "shape of bone of reproductive organ" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0006101 ! bone of reproductive organ morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0007719 ! bone of reproductive organ +intersection_of: RO:0000052 UBERON:0007719 ! inheres in bone of reproductive organ [Term] id: OBA:0006103 @@ -158270,7 +257626,7 @@ is_a: OBA:0006101 ! bone of reproductive organ morphology is_a: OBA:1000138 ! bone element size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0007719 ! bone of reproductive organ +intersection_of: RO:0000052 UBERON:0007719 ! inheres in bone of reproductive organ [Term] id: OBA:0006104 @@ -158281,7 +257637,7 @@ is_a: OBA:0006101 ! bone of reproductive organ morphology is_a: OBA:1000138 ! bone element size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0007719 ! bone of reproductive organ +intersection_of: RO:0000052 UBERON:0007719 ! inheres in bone of reproductive organ [Term] id: OBA:0006112 @@ -158291,7 +257647,7 @@ synonym: "shape of os penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004611 ! os penis morphology is_a: OBA:0006102 ! bone of reproductive organ shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006435 ! os penis +intersection_of: RO:0000052 UBERON:0006435 ! inheres in os penis [Term] id: OBA:0006113 @@ -158301,7 +257657,7 @@ synonym: "width of os penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004612 ! os penis size is_a: OBA:0006103 ! bone of reproductive organ width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0006435 ! os penis +intersection_of: RO:0000052 UBERON:0006435 ! inheres in os penis [Term] id: OBA:0006114 @@ -158311,7 +257667,7 @@ synonym: "length of os penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004612 ! os penis size is_a: OBA:0006104 ! bone of reproductive organ length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006435 ! os penis +intersection_of: RO:0000052 UBERON:0006435 ! inheres in os penis [Term] id: OBA:0006122 @@ -158321,7 +257677,7 @@ synonym: "shape of os clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005582 ! os clitoris morphology is_a: OBA:0006102 ! bone of reproductive organ shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006440 ! os clitoris +intersection_of: RO:0000052 UBERON:0006440 ! inheres in os clitoris [Term] id: OBA:0006123 @@ -158331,7 +257687,7 @@ synonym: "width of os clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005582 ! os clitoris morphology is_a: OBA:0006103 ! bone of reproductive organ width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0006440 ! os clitoris +intersection_of: RO:0000052 UBERON:0006440 ! inheres in os clitoris [Term] id: OBA:0006124 @@ -158341,7 +257697,7 @@ synonym: "length of os clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005582 ! os clitoris morphology is_a: OBA:0006104 ! bone of reproductive organ length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006440 ! os clitoris +intersection_of: RO:0000052 UBERON:0006440 ! inheres in os clitoris [Term] id: OBA:0007000 @@ -158350,8 +257706,8 @@ def: "The macromolecular stability of a DNA." [AUTO:patterns/patterns/entity_att synonym: "macromolecular stability of DNA" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0001001 ! macromolecular stability intersection_of: OBA:0001001 ! macromolecular stability -intersection_of: inheres_in SO:0000352 ! DNA -relationship: inheres_in SO:0000352 ! DNA +intersection_of: RO:0000052 SO:0000352 ! inheres in DNA +relationship: RO:0000052 SO:0000352 ! inheres in DNA [Term] id: OBA:0100001 @@ -158360,8 +257716,8 @@ def: "The quality of a cellular_component." [AUTO:patterns/patterns/entity_attri synonym: "quality of cellular_component" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000001 {is_asserted="true"} ! biological attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005575 ! cellular_component -relationship: inheres_in GO:0005575 ! cellular_component +intersection_of: RO:0000052 GO:0005575 ! inheres in cellular_component +relationship: RO:0000052 GO:0005575 ! inheres in cellular_component [Term] id: OBA:0100002 @@ -158370,8 +257726,8 @@ def: "The quality of a biological_process." [AUTO:patterns/patterns/entity_attri synonym: "quality of biological_process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000001 {is_asserted="true"} ! biological attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008150 ! biological_process -relationship: inheres_in GO:0008150 ! biological_process +intersection_of: RO:0000052 GO:0008150 ! inheres in biological_process +relationship: RO:0000052 GO:0008150 ! inheres in biological_process [Term] id: OBA:0100003 @@ -158380,8 +257736,8 @@ def: "The quality of a anatomical entity." [AUTO:patterns/patterns/entity_attrib synonym: "quality of anatomical entity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000001 {is_asserted="true"} ! biological attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001062 ! anatomical entity -relationship: inheres_in UBERON:0001062 ! anatomical entity +intersection_of: RO:0000052 UBERON:0001062 ! inheres in anatomical entity +relationship: RO:0000052 UBERON:0001062 ! inheres in anatomical entity [Term] id: OBA:0100004 @@ -158390,8 +257746,8 @@ def: "The quality of a chemical entity." [AUTO:patterns/patterns/entity_attribut synonym: "quality of chemical entity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000001 {is_asserted="true"} ! biological attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CHEBI:24431 ! chemical entity -relationship: inheres_in CHEBI:24431 ! chemical entity +intersection_of: RO:0000052 CHEBI:24431 ! inheres in chemical entity +relationship: RO:0000052 CHEBI:24431 ! inheres in chemical entity [Term] id: OBA:0100005 @@ -158400,8 +257756,8 @@ def: "The quality of a protein." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of protein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PR:000000001 ! protein -relationship: inheres_in PR:000000001 ! protein +intersection_of: RO:0000052 PR:000000001 ! inheres in protein +relationship: RO:0000052 PR:000000001 ! inheres in protein [Term] id: OBA:1000001 @@ -158412,7 +257768,7 @@ synonym: "permeability of blood brain barrier" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0000075 ! blood-brain barrier morphology trait is_a: PATO:0000970 ! permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in UBERON:0000120 ! blood brain barrier +intersection_of: RO:0000052 UBERON:0000120 ! inheres in blood brain barrier created_by: cjmungall creation_date: 2013-05-15T00:36:22Z @@ -158425,8 +257781,8 @@ synonym: "length of line connecting laterally paired nipples" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0013771 ! line connecting laterally paired nipples -relationship: inheres_in UBERON:0013771 ! line connecting laterally paired nipples +intersection_of: RO:0000052 UBERON:0013771 ! inheres in line connecting laterally paired nipples +relationship: RO:0000052 UBERON:0013771 ! inheres in line connecting laterally paired nipples created_by: cjmungall creation_date: 2013-05-15T00:42:06Z @@ -158439,8 +257795,8 @@ synonym: "length of anatomical line between inner canthi" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0013678 ! anatomical line between inner canthi -relationship: inheres_in UBERON:0013678 ! anatomical line between inner canthi +intersection_of: RO:0000052 UBERON:0013678 ! inheres in anatomical line between inner canthi +relationship: RO:0000052 UBERON:0013678 ! inheres in anatomical line between inner canthi created_by: cjmungall creation_date: 2013-05-15T00:42:08Z @@ -158453,8 +257809,8 @@ synonym: "length of anatomical line between outer ears" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0010231 ! anatomical line between outer ears -relationship: inheres_in UBERON:0010231 ! anatomical line between outer ears +intersection_of: RO:0000052 UBERON:0010231 ! inheres in anatomical line between outer ears +relationship: RO:0000052 UBERON:0010231 ! inheres in anatomical line between outer ears created_by: cjmungall creation_date: 2013-05-15T00:42:11Z @@ -158467,8 +257823,8 @@ synonym: "length of anatomical line between pupils" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0010222 ! anatomical line between pupils -relationship: inheres_in UBERON:0010222 ! anatomical line between pupils +intersection_of: RO:0000052 UBERON:0010222 ! inheres in anatomical line between pupils +relationship: RO:0000052 UBERON:0010222 ! inheres in anatomical line between pupils created_by: cjmungall creation_date: 2013-05-15T00:42:13Z @@ -158482,7 +257838,7 @@ is_a: OBA:0000051 ! cell projection size is_a: OBA:0005766 ! cilium morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005929 ! cilium +intersection_of: RO:0000052 GO:0005929 ! inheres in cilium created_by: cjmungall creation_date: 2013-05-15T00:55:27Z @@ -158495,7 +257851,7 @@ synonym: "length of dendrite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000123 ! dendrite size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2013-05-15T00:55:30Z @@ -158508,8 +257864,8 @@ synonym: "microtubule length trait" EXACT [GOC:TermGenie] is_a: OBA:0000057 ! cellular component size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005874 ! microtubule -relationship: inheres_in GO:0005874 ! microtubule +intersection_of: RO:0000052 GO:0005874 ! inheres in microtubule +relationship: RO:0000052 GO:0005874 ! inheres in microtubule created_by: cjmungall creation_date: 2013-05-15T05:48:55Z @@ -158522,8 +257878,8 @@ synonym: "size of mitochondrial nucleoid" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0042645 ! mitochondrial nucleoid -relationship: inheres_in GO:0042645 ! mitochondrial nucleoid +intersection_of: RO:0000052 GO:0042645 ! inheres in mitochondrial nucleoid +relationship: RO:0000052 GO:0042645 ! inheres in mitochondrial nucleoid created_by: cjmungall creation_date: 2013-05-15T05:48:58Z @@ -158537,8 +257893,8 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005819 ! spindle -relationship: inheres_in GO:0005819 ! spindle +intersection_of: RO:0000052 GO:0005819 ! inheres in spindle +relationship: RO:0000052 GO:0005819 ! inheres in spindle created_by: cjmungall creation_date: 2013-05-15T05:49:01Z @@ -158551,8 +257907,8 @@ synonym: "morphology of Golgi apparatus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005794 ! Golgi apparatus -relationship: inheres_in GO:0005794 ! Golgi apparatus +intersection_of: RO:0000052 GO:0005794 ! inheres in Golgi apparatus +relationship: RO:0000052 GO:0005794 ! inheres in Golgi apparatus created_by: cjmungall creation_date: 2013-05-15T05:49:03Z @@ -158566,8 +257922,8 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:1000013 ! cytoskeleton morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0032172 ! germ tube septin ring -relationship: inheres_in GO:0032172 ! germ tube septin ring +intersection_of: RO:0000052 GO:0032172 ! inheres in germ tube septin ring +relationship: RO:0000052 GO:0032172 ! inheres in germ tube septin ring created_by: cjmungall creation_date: 2013-05-15T05:49:06Z @@ -158580,8 +257936,8 @@ synonym: "morphology of cytoskeleton" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005856 ! cytoskeleton -relationship: inheres_in GO:0005856 ! cytoskeleton +intersection_of: RO:0000052 GO:0005856 ! inheres in cytoskeleton +relationship: RO:0000052 GO:0005856 ! inheres in cytoskeleton created_by: cjmungall creation_date: 2013-05-15T05:53:18Z @@ -158594,8 +257950,8 @@ synonym: "morphology of endomembrane system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0012505 ! endomembrane system -relationship: inheres_in GO:0012505 ! endomembrane system +intersection_of: RO:0000052 GO:0012505 ! inheres in endomembrane system +relationship: RO:0000052 GO:0012505 ! inheres in endomembrane system created_by: cjmungall creation_date: 2013-05-15T05:53:21Z @@ -158608,8 +257964,8 @@ synonym: "morphology of lipid droplet" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005811 ! lipid droplet -relationship: inheres_in GO:0005811 ! lipid droplet +intersection_of: RO:0000052 GO:0005811 ! inheres in lipid droplet +relationship: RO:0000052 GO:0005811 ! inheres in lipid droplet created_by: cjmungall creation_date: 2013-05-15T05:53:24Z @@ -158622,8 +257978,8 @@ synonym: "morphology of mating projection" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005937 ! mating projection -relationship: inheres_in GO:0005937 ! mating projection +intersection_of: RO:0000052 GO:0005937 ! inheres in mating projection +relationship: RO:0000052 GO:0005937 ! inheres in mating projection created_by: cjmungall creation_date: 2013-05-15T05:53:26Z @@ -158636,8 +257992,8 @@ synonym: "mating projection tip length trait" EXACT [GOC:TermGenie] is_a: OBA:0000057 ! cellular component size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0043332 ! mating projection tip -relationship: inheres_in GO:0043332 ! mating projection tip +intersection_of: RO:0000052 GO:0043332 ! inheres in mating projection tip +relationship: RO:0000052 GO:0043332 ! inheres in mating projection tip created_by: cjmungall creation_date: 2013-05-15T05:53:29Z @@ -158650,7 +258006,7 @@ synonym: "shape of nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000019 ! nucleus morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus created_by: cjmungall creation_date: 2013-05-15T05:55:08Z @@ -158663,8 +258019,8 @@ synonym: "nucleus morphology trait" EXACT [GOC:TermGenie] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005634 ! nucleus -relationship: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus +relationship: RO:0000052 GO:0005634 ! inheres in nucleus created_by: cjmungall creation_date: 2013-05-15T05:56:08Z @@ -158676,8 +258032,8 @@ synonym: "cotyledon size trait" EXACT [GOC:TermGenie] synonym: "size of cotyledon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in PO:0020030 ! cotyledon -relationship: inheres_in PO:0020030 ! cotyledon +intersection_of: RO:0000052 PO:0020030 ! inheres in cotyledon +relationship: RO:0000052 PO:0020030 ! inheres in cotyledon created_by: cjmungall creation_date: 2013-05-15T17:27:00Z @@ -158689,8 +258045,8 @@ synonym: "quality of subcutaneous adipose tissue" EXACT [AUTO:patterns/patterns/ synonym: "subcutaneous adipose tissue quality trait" EXACT [GOC:TermGenie] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue -relationship: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue +relationship: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue created_by: cjmungall creation_date: 2013-06-05T19:18:57Z @@ -158703,7 +258059,7 @@ synonym: "subcutaneous adipose tissue proportionality to trait" EXACT [GOC:TermG is_a: OBA:1000023 ! subcutaneous adipose tissue quality is_a: PATO:0001470 ! proportionality to intersection_of: PATO:0001470 ! proportionality to -intersection_of: inheres_in UBERON:0002190 ! subcutaneous adipose tissue +intersection_of: RO:0000052 UBERON:0002190 ! inheres in subcutaneous adipose tissue created_by: cjmungall creation_date: 2013-06-05T19:19:33Z @@ -158715,8 +258071,8 @@ synonym: "breast size trait" EXACT [GOC:TermGenie] synonym: "size of breast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000310 ! breast -relationship: inheres_in UBERON:0000310 ! breast +intersection_of: RO:0000052 UBERON:0000310 ! inheres in breast +relationship: RO:0000052 UBERON:0000310 ! inheres in breast created_by: cjmungall creation_date: 2013-06-05T19:22:16Z @@ -158728,8 +258084,8 @@ synonym: "intervertebral disk of lumbar vertebra morphology trait" EXACT [GOC:Te synonym: "morphology of intervertebral disk of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004173 ! intervertebral disk morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007255 ! intervertebral disk of lumbar vertebra -relationship: inheres_in UBERON:0007255 ! intervertebral disk of lumbar vertebra +intersection_of: RO:0000052 UBERON:0007255 ! inheres in intervertebral disk of lumbar vertebra +relationship: RO:0000052 UBERON:0007255 ! inheres in intervertebral disk of lumbar vertebra created_by: cjmungall creation_date: 2013-06-05T19:26:27Z @@ -158742,7 +258098,7 @@ synonym: "volume of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0005355 ! thyroid gland size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland created_by: cjmungall creation_date: 2013-06-05T19:26:29Z @@ -158755,7 +258111,7 @@ synonym: "permeability of membrane" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000091 ! membrane morphology is_a: PATO:0000970 ! permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in GO:0016020 ! membrane +intersection_of: RO:0000052 GO:0016020 ! inheres in membrane created_by: cjmungall creation_date: 2013-06-11T07:21:47Z @@ -158768,7 +258124,7 @@ synonym: "shape of cerebellum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000849 ! cerebellum morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002037 ! cerebellum +intersection_of: RO:0000052 UBERON:0002037 ! inheres in cerebellum created_by: vasilevs creation_date: 2013-06-12T22:46:08Z @@ -158782,7 +258138,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003854 ! forelimb stylopod morphology trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0003822 ! forelimb stylopod +intersection_of: RO:0000052 UBERON:0003822 ! inheres in forelimb stylopod created_by: cjmungall creation_date: 2013-06-17T17:53:31Z @@ -158795,7 +258151,7 @@ synonym: "neck circumference trait" EXACT [GOC:TermGenie] is_a: OBA:0002103 ! neck size is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0000974 ! neck +intersection_of: RO:0000052 UBERON:0000974 ! inheres in neck created_by: cjmungall creation_date: 2013-06-17T17:53:34Z @@ -158809,8 +258165,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0001464 ! hip -relationship: inheres_in UBERON:0001464 ! hip +intersection_of: RO:0000052 UBERON:0001464 ! inheres in hip +relationship: RO:0000052 UBERON:0001464 ! inheres in hip created_by: cjmungall creation_date: 2013-06-17T17:53:37Z @@ -158824,7 +258180,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003856 ! hindlimb stylopod morphology trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0000376 ! hindlimb stylopod +intersection_of: RO:0000052 UBERON:0000376 ! inheres in hindlimb stylopod created_by: cjmungall creation_date: 2013-06-17T17:53:39Z @@ -158838,7 +258194,7 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:1000087 ! cell surface morphology is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in GO:0009986 ! cell surface +intersection_of: RO:0000052 GO:0009986 ! inheres in cell surface relationship: http://purl.org/pav/providedBy http://eol.org created_by: jen.hammock creation_date: 2013-08-06T20:05:54Z @@ -158854,7 +258210,7 @@ synonym: "opacity of lens of camera-type eye" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000227 ! lens of camera-type eye quality is_a: PATO:0000957 ! opacity intersection_of: PATO:0000957 ! opacity -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye created_by: cjmungall creation_date: 2013-09-25T23:32:06Z @@ -158867,7 +258223,7 @@ synonym: "mass of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell relationship: http://purl.org/pav/providedBy http://eol.org created_by: jen.hammock creation_date: 2013-09-30T20:01:39Z @@ -158880,9 +258236,9 @@ synonym: "adult organism mass trait" EXACT [GOC:TermGenie] synonym: "mass of adult organism" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001259 ! body mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007023 ! adult organism +intersection_of: RO:0000052 UBERON:0007023 ! inheres in adult organism relationship: http://purl.org/pav/providedBy http://eol.org -relationship: inheres_in UBERON:0007023 ! adult organism +relationship: RO:0000052 UBERON:0007023 ! inheres in adult organism created_by: jen.hammock creation_date: 2013-10-08T20:29:11Z @@ -158895,7 +258251,7 @@ synonym: "mollusc shell height trait" EXACT [GOC:TermGenie] is_a: OBA:1000051 ! mollusc shell quality is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0008270 ! mollusc shell +intersection_of: RO:0000052 UBERON:0008270 ! inheres in mollusc shell relationship: http://purl.org/pav/providedBy http://eol.org created_by: jen.hammock creation_date: 2013-10-08T21:19:32Z @@ -158909,7 +258265,7 @@ synonym: "mollusc shell length trait" EXACT [GOC:TermGenie] is_a: OBA:1000051 ! mollusc shell quality is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008270 ! mollusc shell +intersection_of: RO:0000052 UBERON:0008270 ! inheres in mollusc shell relationship: http://purl.org/pav/providedBy http://eol.org created_by: jen.hammock creation_date: 2013-10-08T21:21:38Z @@ -158922,8 +258278,8 @@ synonym: "secondary xylem volumetric density trait" EXACT [GOC:TermGenie] synonym: "volumetric density of secondary xylem" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0001353 ! volumetric density intersection_of: PATO:0001353 ! volumetric density -intersection_of: inheres_in PO:0005848 ! secondary xylem -relationship: inheres_in PO:0005848 ! secondary xylem +intersection_of: RO:0000052 PO:0005848 ! inheres in secondary xylem +relationship: RO:0000052 PO:0005848 ! inheres in secondary xylem created_by: eolspecies creation_date: 2013-10-22T16:26:19Z @@ -158935,8 +258291,8 @@ synonym: "color of cotyledonary node" EXACT [AUTO:patterns/patterns/entity_attri synonym: "cotyledonary node color trait" EXACT [GOC:TermGenie] is_a: OBA:1000043 ! shoot node color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in PO:0025321 ! cotyledonary node -relationship: inheres_in PO:0025321 ! cotyledonary node +intersection_of: RO:0000052 PO:0025321 ! inheres in cotyledonary node +relationship: RO:0000052 PO:0025321 ! inheres in cotyledonary node created_by: cjmungall creation_date: 2013-10-29T21:11:53Z @@ -158948,8 +258304,8 @@ synonym: "color of scutellar node" EXACT [AUTO:patterns/patterns/entity_attribut synonym: "scutellar node color trait" EXACT [GOC:TermGenie] is_a: OBA:1000043 ! shoot node color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in PO:0004708 ! scutellar node -relationship: inheres_in PO:0004708 ! scutellar node +intersection_of: RO:0000052 PO:0004708 ! inheres in scutellar node +relationship: RO:0000052 PO:0004708 ! inheres in scutellar node created_by: cjmungall creation_date: 2013-10-29T21:11:59Z @@ -158961,8 +258317,8 @@ synonym: "color of shoot axis node" EXACT [AUTO:patterns/patterns/entity_attribu synonym: "shoot node color trait" EXACT [GOC:TermGenie] is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in PO:0005004 ! shoot axis node -relationship: inheres_in PO:0005004 ! shoot axis node +intersection_of: RO:0000052 PO:0005004 ! inheres in shoot axis node +relationship: RO:0000052 PO:0005004 ! inheres in shoot axis node created_by: cjmungall creation_date: 2013-10-29T21:15:42Z @@ -158977,7 +258333,7 @@ synonym: "iris color trait" EXACT [GOC:TermGenie] is_a: OBA:VT0001322 ! iris morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris created_by: cjmungall creation_date: 2014-01-21T22:46:17Z @@ -158990,7 +258346,7 @@ synonym: "philtrum length trait" EXACT [GOC:TermGenie] is_a: OBA:0002061 ! philtrum size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum created_by: cjmungall creation_date: 2014-01-27T23:37:06Z @@ -159003,7 +258359,7 @@ synonym: "palpebral fissure length trait" EXACT [GOC:TermGenie] is_a: OBA:0002118 ! palpebral fissure size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001819 ! palpebral fissure +intersection_of: RO:0000052 UBERON:0001819 ! inheres in palpebral fissure created_by: cjmungall creation_date: 2014-01-27T23:50:54Z @@ -159017,7 +258373,7 @@ synonym: "manus length trait" EXACT [GOC:TermGenie] is_a: OBA:0002188 ! manus size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002398 ! manus +intersection_of: RO:0000052 UBERON:0002398 ! inheres in manus created_by: cjmungall creation_date: 2014-01-27T23:51:00Z @@ -159031,7 +258387,7 @@ synonym: "pes length trait" EXACT [GOC:TermGenie] is_a: OBA:VT0000573 ! hind paw size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002387 ! pes +intersection_of: RO:0000052 UBERON:0002387 ! inheres in pes created_by: cjmungall creation_date: 2014-01-27T23:51:06Z @@ -159045,7 +258401,7 @@ synonym: "palmar part of manus length trait" EXACT [GOC:TermGenie] is_a: OBA:0002187 ! palmar part of manus size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008878 ! palmar part of manus +intersection_of: RO:0000052 UBERON:0008878 ! inheres in palmar part of manus created_by: cjmungall creation_date: 2014-01-27T23:51:13Z @@ -159057,8 +258413,8 @@ synonym: "mollusc shell quality trait" EXACT [GOC:TermGenie] synonym: "quality of mollusc shell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008270 ! mollusc shell -relationship: inheres_in UBERON:0008270 ! mollusc shell +intersection_of: RO:0000052 UBERON:0008270 ! inheres in mollusc shell +relationship: RO:0000052 UBERON:0008270 ! inheres in mollusc shell created_by: cjmungall creation_date: 2014-02-02T00:49:01Z @@ -159070,8 +258426,8 @@ synonym: "columnella quality trait" EXACT [GOC:TermGenie] synonym: "quality of columnella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008283 ! columnella -relationship: inheres_in UBERON:0008283 ! columnella +intersection_of: RO:0000052 UBERON:0008283 ! inheres in columnella +relationship: RO:0000052 UBERON:0008283 ! inheres in columnella created_by: cjmungall creation_date: 2014-02-02T00:49:08Z @@ -159083,8 +258439,8 @@ synonym: "albumen gland quality trait" EXACT [GOC:TermGenie] synonym: "quality of gastropod albumen gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008935 ! gastropod albumen gland -relationship: inheres_in UBERON:0008935 ! gastropod albumen gland +intersection_of: RO:0000052 UBERON:0008935 ! inheres in gastropod albumen gland +relationship: RO:0000052 UBERON:0008935 ! inheres in gastropod albumen gland created_by: cjmungall creation_date: 2014-02-02T00:49:14Z @@ -159096,8 +258452,8 @@ synonym: "headfoot quality trait" EXACT [GOC:TermGenie] synonym: "quality of headfoot" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008943 ! headfoot -relationship: inheres_in UBERON:0008943 ! headfoot +intersection_of: RO:0000052 UBERON:0008943 ! inheres in headfoot +relationship: RO:0000052 UBERON:0008943 ! inheres in headfoot created_by: cjmungall creation_date: 2014-02-02T00:49:20Z @@ -159109,8 +258465,8 @@ synonym: "osphradium quality trait" EXACT [GOC:TermGenie] synonym: "quality of osphradium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007770 ! osphradium -relationship: inheres_in UBERON:0007770 ! osphradium +intersection_of: RO:0000052 UBERON:0007770 ! inheres in osphradium +relationship: RO:0000052 UBERON:0007770 ! inheres in osphradium created_by: cjmungall creation_date: 2014-02-02T00:49:26Z @@ -159122,8 +258478,8 @@ synonym: "nacre quality trait" EXACT [GOC:TermGenie] synonym: "quality of nacre" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008269 ! nacre -relationship: inheres_in UBERON:0008269 ! nacre +intersection_of: RO:0000052 UBERON:0008269 ! inheres in nacre +relationship: RO:0000052 UBERON:0008269 ! inheres in nacre created_by: cjmungall creation_date: 2014-02-02T00:49:32Z @@ -159135,8 +258491,8 @@ synonym: "gland quality trait" EXACT [GOC:TermGenie] synonym: "quality of gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002530 ! gland -relationship: inheres_in UBERON:0002530 ! gland +intersection_of: RO:0000052 UBERON:0002530 ! inheres in gland +relationship: RO:0000052 UBERON:0002530 ! inheres in gland created_by: cjmungall creation_date: 2014-02-02T00:49:38Z @@ -159148,8 +258504,8 @@ synonym: "quality of visceral hump" EXACT [AUTO:patterns/patterns/entity_attribu synonym: "visceral hump quality trait" EXACT [GOC:TermGenie] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008937 ! visceral hump -relationship: inheres_in UBERON:0008937 ! visceral hump +intersection_of: RO:0000052 UBERON:0008937 ! inheres in visceral hump +relationship: RO:0000052 UBERON:0008937 ! inheres in visceral hump created_by: cjmungall creation_date: 2014-02-02T00:49:45Z @@ -159161,8 +258517,8 @@ synonym: "parapodium quality trait" EXACT [GOC:TermGenie] synonym: "quality of parapodium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0009473 ! parapodium -relationship: inheres_in UBERON:0009473 ! parapodium +intersection_of: RO:0000052 UBERON:0009473 ! inheres in parapodium +relationship: RO:0000052 UBERON:0009473 ! inheres in parapodium created_by: cjmungall creation_date: 2014-02-02T01:20:31Z @@ -159174,8 +258530,8 @@ synonym: "prostomium quality trait" EXACT [GOC:TermGenie] synonym: "quality of prostomium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008834 ! prostomium -relationship: inheres_in UBERON:0008834 ! prostomium +intersection_of: RO:0000052 UBERON:0008834 ! inheres in prostomium +relationship: RO:0000052 UBERON:0008834 ! inheres in prostomium created_by: cjmungall creation_date: 2014-02-02T01:20:37Z @@ -159187,8 +258543,8 @@ synonym: "quality of vestimentum muscle" EXACT [AUTO:patterns/patterns/entity_at synonym: "vestimentum muscle quality trait" EXACT [GOC:TermGenie] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0012642 ! vestimentum muscle -relationship: inheres_in UBERON:0012642 ! vestimentum muscle +intersection_of: RO:0000052 UBERON:0012642 ! inheres in vestimentum muscle +relationship: RO:0000052 UBERON:0012642 ! inheres in vestimentum muscle created_by: cjmungall creation_date: 2014-02-02T01:20:43Z @@ -159200,8 +258556,8 @@ synonym: "quality of trophosome" EXACT [AUTO:patterns/patterns/entity_attribute] synonym: "trophosome quality trait" EXACT [GOC:TermGenie] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0012644 ! trophosome -relationship: inheres_in UBERON:0012644 ! trophosome +intersection_of: RO:0000052 UBERON:0012644 ! inheres in trophosome +relationship: RO:0000052 UBERON:0012644 ! inheres in trophosome created_by: cjmungall creation_date: 2014-02-02T01:20:49Z @@ -159213,8 +258569,8 @@ synonym: "opisthosome quality trait" EXACT [GOC:TermGenie] synonym: "quality of opisthosome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0012645 ! opisthosome -relationship: inheres_in UBERON:0012645 ! opisthosome +intersection_of: RO:0000052 UBERON:0012645 ! inheres in opisthosome +relationship: RO:0000052 UBERON:0012645 ! inheres in opisthosome created_by: cjmungall creation_date: 2014-02-02T01:20:55Z @@ -159226,8 +258582,8 @@ synonym: "dermal bone quality trait" EXACT [GOC:TermGenie] synonym: "quality of dermal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008907 ! dermal bone -relationship: inheres_in UBERON:0008907 ! dermal bone +intersection_of: RO:0000052 UBERON:0008907 ! inheres in dermal bone +relationship: RO:0000052 UBERON:0008907 ! inheres in dermal bone created_by: cjmungall creation_date: 2014-02-22T16:19:16Z @@ -159240,7 +258596,7 @@ synonym: "morphology of dermal bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000064 ! dermal bone quality is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008907 ! dermal bone +intersection_of: RO:0000052 UBERON:0008907 ! inheres in dermal bone created_by: cjmungall creation_date: 2014-02-22T16:24:50Z @@ -159253,7 +258609,7 @@ synonym: "morphology of endochondral bone" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002513 ! endochondral bone +intersection_of: RO:0000052 UBERON:0002513 ! inheres in endochondral bone created_by: cjmungall creation_date: 2014-02-22T16:24:56Z @@ -159265,8 +258621,8 @@ synonym: "endochondral bone quality trait" EXACT [GOC:TermGenie] synonym: "quality of endochondral bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002513 ! endochondral bone -relationship: inheres_in UBERON:0002513 ! endochondral bone +intersection_of: RO:0000052 UBERON:0002513 ! inheres in endochondral bone +relationship: RO:0000052 UBERON:0002513 ! inheres in endochondral bone created_by: cjmungall creation_date: 2014-02-22T16:25:02Z @@ -159279,8 +258635,8 @@ synonym: "size of epiplastron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011658 ! epiplastron -relationship: inheres_in UBERON:0011658 ! epiplastron +intersection_of: RO:0000052 UBERON:0011658 ! inheres in epiplastron +relationship: RO:0000052 UBERON:0011658 ! inheres in epiplastron created_by: cjmungall creation_date: 2014-02-22T16:56:12Z @@ -159293,8 +258649,8 @@ synonym: "mass of epiplastron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000064 ! dermal bone quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0011658 ! epiplastron -relationship: inheres_in UBERON:0011658 ! epiplastron +intersection_of: RO:0000052 UBERON:0011658 ! inheres in epiplastron +relationship: RO:0000052 UBERON:0011658 ! inheres in epiplastron created_by: cjmungall creation_date: 2014-02-22T16:56:18Z @@ -159307,8 +258663,8 @@ synonym: "xiphiplastron size trait" EXACT [GOC:TermGenie] is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000138 ! bone element size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0011661 ! xiphiplastron -relationship: inheres_in UBERON:0011661 ! xiphiplastron +intersection_of: RO:0000052 UBERON:0011661 ! inheres in xiphiplastron +relationship: RO:0000052 UBERON:0011661 ! inheres in xiphiplastron created_by: cjmungall creation_date: 2014-02-22T16:56:25Z @@ -159321,7 +258677,7 @@ synonym: "color of coat of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003645 ! coat of hair morphology is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair created_by: cjmungall creation_date: 2014-03-06T04:45:10Z @@ -159334,7 +258690,7 @@ synonym: "color pattern of coat of hair" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000073 ! coat spatial pattern is_a: PATO:0000019 ! color pattern intersection_of: PATO:0000019 ! color pattern -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair created_by: cjmungall creation_date: 2014-03-06T04:45:14Z @@ -159347,7 +258703,7 @@ synonym: "spatial pattern of coat of hair" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003645 ! coat of hair morphology is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0010166 ! coat of hair +intersection_of: RO:0000052 UBERON:0010166 ! inheres in coat of hair created_by: cjmungall creation_date: 2014-03-06T04:45:18Z @@ -159359,8 +258715,8 @@ synonym: "size of antenna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015071 ! appendage morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000972 ! antenna -relationship: inheres_in UBERON:0000972 ! antenna +intersection_of: RO:0000052 UBERON:0000972 ! inheres in antenna +relationship: RO:0000052 UBERON:0000972 ! inheres in antenna created_by: caripark creation_date: 2014-04-11T18:52:34Z @@ -159373,7 +258729,7 @@ synonym: "cytosol color trait" EXACT [GOC:TermGenie] is_a: OBA:1000077 ! attribute of cytosol is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in GO:0005829 ! cytosol +intersection_of: RO:0000052 GO:0005829 ! inheres in cytosol relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-06-04T18:58:27Z @@ -159386,8 +258742,8 @@ synonym: "cell quality trait" EXACT [GOC:TermGenie] synonym: "quality of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000000 ! cell -relationship: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell +relationship: RO:0000052 CL:0000000 ! inheres in cell created_by: cjmungall creation_date: 2014-06-04T19:24:06Z @@ -159399,8 +258755,8 @@ synonym: "cytosol quality trait" EXACT [GOC:TermGenie] synonym: "quality of cytosol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005829 ! cytosol -relationship: inheres_in GO:0005829 ! cytosol +intersection_of: RO:0000052 GO:0005829 ! inheres in cytosol +relationship: RO:0000052 GO:0005829 ! inheres in cytosol created_by: cjmungall creation_date: 2014-06-04T19:24:09Z @@ -159412,8 +258768,8 @@ synonym: "organelle quality trait" EXACT [GOC:TermGenie] synonym: "quality of organelle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043226 ! organelle -relationship: inheres_in GO:0043226 ! organelle +intersection_of: RO:0000052 GO:0043226 ! inheres in organelle +relationship: RO:0000052 GO:0043226 ! inheres in organelle created_by: cjmungall creation_date: 2014-06-04T19:24:13Z @@ -159426,8 +258782,8 @@ synonym: "strength of muscle organ" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ created_by: cjmungall creation_date: 2014-06-04T19:27:04Z @@ -159439,8 +258795,8 @@ synonym: "skeletal muscle organ strength trait" EXACT [GOC:TermGenie] synonym: "strength of skeletal muscle organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000079 ! muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0014892 ! skeletal muscle organ -relationship: inheres_in UBERON:0014892 ! skeletal muscle organ +intersection_of: RO:0000052 UBERON:0014892 ! inheres in skeletal muscle organ +relationship: RO:0000052 UBERON:0014892 ! inheres in skeletal muscle organ created_by: cjmungall creation_date: 2014-06-04T19:27:08Z @@ -159452,8 +258808,8 @@ synonym: "forelimb muscle strength trait" EXACT [GOC:TermGenie] synonym: "strength of forelimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000080 ! skeletal muscle organ strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0003662 ! forelimb muscle -relationship: inheres_in UBERON:0003662 ! forelimb muscle +intersection_of: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle +relationship: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle created_by: cjmungall creation_date: 2014-06-04T19:27:11Z @@ -159465,8 +258821,8 @@ synonym: "hindlimb muscle strength trait" EXACT [GOC:TermGenie] synonym: "strength of hindlimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002770 ! pelvic complex muscle strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0003663 ! hindlimb muscle -relationship: inheres_in UBERON:0003663 ! hindlimb muscle +intersection_of: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle +relationship: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle created_by: cjmungall creation_date: 2014-06-04T19:27:15Z @@ -159479,7 +258835,7 @@ synonym: "nucleus length trait" EXACT [GOC:TermGenie] is_a: OBA:0000117 ! nuclear size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-06-04T19:31:50Z @@ -159493,7 +258849,7 @@ synonym: "texture of cell surface" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000087 ! cell surface morphology is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in GO:0009986 ! cell surface +intersection_of: RO:0000052 GO:0009986 ! inheres in cell surface relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-06-04T19:42:11Z @@ -159507,7 +258863,7 @@ synonym: "width of nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000117 ! nuclear size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-06-04T20:31:38Z @@ -159520,8 +258876,8 @@ synonym: "cell surface quality trait" EXACT [GOC:TermGenie] synonym: "quality of cell surface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009986 ! cell surface -relationship: inheres_in GO:0009986 ! cell surface +intersection_of: RO:0000052 GO:0009986 ! inheres in cell surface +relationship: RO:0000052 GO:0009986 ! inheres in cell surface created_by: cjmungall creation_date: 2014-06-06T16:11:26Z @@ -159534,7 +258890,7 @@ synonym: "morphology of cell surface" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000086 ! cell surface quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0009986 ! cell surface +intersection_of: RO:0000052 GO:0009986 ! inheres in cell surface created_by: cjmungall creation_date: 2014-06-06T16:11:30Z @@ -159546,8 +258902,8 @@ synonym: "plasma membrane quality trait" EXACT [GOC:TermGenie] synonym: "quality of plasma membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000090 ! membrane quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005886 ! plasma membrane -relationship: inheres_in GO:0005886 ! plasma membrane +intersection_of: RO:0000052 GO:0005886 ! inheres in plasma membrane +relationship: RO:0000052 GO:0005886 ! inheres in plasma membrane created_by: cjmungall creation_date: 2014-06-06T16:11:34Z @@ -159560,7 +258916,7 @@ synonym: "plasma membrane morphology trait" EXACT [GOC:TermGenie] is_a: OBA:1000088 ! plasma membrane quality is_a: OBA:1000091 ! membrane morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005886 ! plasma membrane +intersection_of: RO:0000052 GO:0005886 ! inheres in plasma membrane created_by: cjmungall creation_date: 2014-06-06T16:11:38Z @@ -159572,8 +258928,8 @@ synonym: "membrane quality trait" EXACT [GOC:TermGenie] synonym: "quality of membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0016020 ! membrane -relationship: inheres_in GO:0016020 ! membrane +intersection_of: RO:0000052 GO:0016020 ! inheres in membrane +relationship: RO:0000052 GO:0016020 ! inheres in membrane created_by: cjmungall creation_date: 2014-06-06T16:11:41Z @@ -159586,7 +258942,7 @@ synonym: "morphology of membrane" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000090 ! membrane quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0016020 ! membrane +intersection_of: RO:0000052 GO:0016020 ! inheres in membrane created_by: cjmungall creation_date: 2014-06-06T16:11:45Z @@ -159599,9 +258955,9 @@ synonym: "shape of dinoflagellate cingulum" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097611 ! dinoflagellate cingulum +intersection_of: RO:0000052 GO:0097611 ! inheres in dinoflagellate cingulum relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097611 ! dinoflagellate cingulum +relationship: RO:0000052 GO:0097611 ! inheres in dinoflagellate cingulum created_by: annethessen creation_date: 2014-06-25T00:10:46Z @@ -159614,9 +258970,9 @@ synonym: "shape of dinoflagellate sulcus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097612 ! dinoflagellate sulcus +intersection_of: RO:0000052 GO:0097612 ! inheres in dinoflagellate sulcus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097612 ! dinoflagellate sulcus +relationship: RO:0000052 GO:0097612 ! inheres in dinoflagellate sulcus created_by: annethessen creation_date: 2014-06-27T17:49:26Z @@ -159629,9 +258985,9 @@ synonym: "shape of chloroplast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0009507 ! chloroplast +intersection_of: RO:0000052 GO:0009507 ! inheres in chloroplast relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0009507 ! chloroplast +relationship: RO:0000052 GO:0009507 ! inheres in chloroplast created_by: annethessen creation_date: 2014-07-01T14:09:53Z @@ -159644,9 +259000,9 @@ synonym: "spatial pattern of chloroplast" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in GO:0009507 ! chloroplast +intersection_of: RO:0000052 GO:0009507 ! inheres in chloroplast relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0009507 ! chloroplast +relationship: RO:0000052 GO:0009507 ! inheres in chloroplast created_by: annethessen creation_date: 2014-07-01T14:46:16Z @@ -159659,9 +259015,9 @@ synonym: "color of chloroplast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in GO:0009507 ! chloroplast +intersection_of: RO:0000052 GO:0009507 ! inheres in chloroplast relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0009507 ! chloroplast +relationship: RO:0000052 GO:0009507 ! inheres in chloroplast created_by: annethessen creation_date: 2014-07-01T15:18:01Z @@ -159674,9 +259030,9 @@ synonym: "size of chloroplast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0009507 ! chloroplast +intersection_of: RO:0000052 GO:0009507 ! inheres in chloroplast relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0009507 ! chloroplast +relationship: RO:0000052 GO:0009507 ! inheres in chloroplast created_by: annethessen creation_date: 2014-07-01T17:59:40Z @@ -159689,9 +259045,9 @@ synonym: "width of dinoflagellate sulcus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000057 ! cellular component size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in GO:0097612 ! dinoflagellate sulcus +intersection_of: RO:0000052 GO:0097612 ! inheres in dinoflagellate sulcus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097612 ! dinoflagellate sulcus +relationship: RO:0000052 GO:0097612 ! inheres in dinoflagellate sulcus created_by: annethessen creation_date: 2014-07-01T20:43:17Z @@ -159703,8 +259059,8 @@ synonym: "appendage quality trait" EXACT [GOC:TermGenie] synonym: "quality of appendage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000026 ! appendage -relationship: inheres_in UBERON:0000026 ! appendage +intersection_of: RO:0000052 UBERON:0000026 ! inheres in appendage +relationship: RO:0000052 UBERON:0000026 ! inheres in appendage created_by: cjmungall creation_date: 2014-07-07T02:17:51Z @@ -159716,8 +259072,8 @@ synonym: "paired fin quality trait" EXACT [GOC:TermGenie] synonym: "quality of paired fin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002534 ! paired fin -relationship: inheres_in UBERON:0002534 ! paired fin +intersection_of: RO:0000052 UBERON:0002534 ! inheres in paired fin +relationship: RO:0000052 UBERON:0002534 ! inheres in paired fin created_by: cjmungall creation_date: 2014-07-07T02:17:54Z @@ -159730,7 +259086,7 @@ synonym: "length of axial skeleton plus cranial skeleton" EXACT [AUTO:patterns/p is_a: OBA:0003443 ! axial skeleton plus cranial skeleton size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0005944 ! axial skeleton plus cranial skeleton +intersection_of: RO:0000052 UBERON:0005944 ! inheres in axial skeleton plus cranial skeleton created_by: cjmungall creation_date: 2014-07-07T02:21:22Z @@ -159744,7 +259100,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010086 ! vertebral column morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column created_by: cjmungall creation_date: 2014-07-07T02:21:25Z @@ -159756,8 +259112,8 @@ synonym: "cervical region of vertebral column length trait" EXACT [GOC:TermGenie synonym: "length of cervical region of vertebral column" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000104 ! subdivision of vertebral column length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006072 ! cervical region of vertebral column -relationship: inheres_in UBERON:0006072 ! cervical region of vertebral column +intersection_of: RO:0000052 UBERON:0006072 ! inheres in cervical region of vertebral column +relationship: RO:0000052 UBERON:0006072 ! inheres in cervical region of vertebral column created_by: cjmungall creation_date: 2014-07-07T02:21:29Z @@ -159770,8 +259126,8 @@ synonym: "subdivision of vertebral column length trait" EXACT [GOC:TermGenie] is_a: OBA:0000015 ! anatomical structure size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006077 ! subdivision of vertebral column -relationship: inheres_in UBERON:0006077 ! subdivision of vertebral column +intersection_of: RO:0000052 UBERON:0006077 ! inheres in subdivision of vertebral column +relationship: RO:0000052 UBERON:0006077 ! inheres in subdivision of vertebral column created_by: cjmungall creation_date: 2014-07-07T02:21:32Z @@ -159784,8 +259140,8 @@ synonym: "tissue composition trait" EXACT [GOC:TermGenie] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0000479 ! tissue -relationship: inheres_in UBERON:0000479 ! tissue +intersection_of: RO:0000052 UBERON:0000479 ! inheres in tissue +relationship: RO:0000052 UBERON:0000479 ! inheres in tissue created_by: cjmungall creation_date: 2014-07-12T22:00:01Z @@ -159798,8 +259154,8 @@ synonym: "skeletal tissue composition trait" EXACT [GOC:TermGenie] is_a: OBA:1000105 ! tissue composition is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0004755 ! skeletal tissue -relationship: inheres_in UBERON:0004755 ! skeletal tissue +intersection_of: RO:0000052 UBERON:0004755 ! inheres in skeletal tissue +relationship: RO:0000052 UBERON:0004755 ! inheres in skeletal tissue created_by: cjmungall creation_date: 2014-07-12T22:00:04Z @@ -159812,8 +259168,8 @@ synonym: "testis position trait" EXACT [GOC:TermGenie] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis created_by: cjmungall creation_date: 2014-07-15T22:55:29Z @@ -159825,8 +259181,8 @@ synonym: "hoof quality trait" EXACT [GOC:TermGenie] synonym: "quality of hoof" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008963 ! hoof -relationship: inheres_in UBERON:0008963 ! hoof +intersection_of: RO:0000052 UBERON:0008963 ! inheres in hoof +relationship: RO:0000052 UBERON:0008963 ! inheres in hoof created_by: cjmungall creation_date: 2014-07-18T16:52:08Z @@ -159839,8 +259195,8 @@ synonym: "degree of pigmentation of anatomical structure" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002247 ! degree of pigmentation intersection_of: PATO:0002247 ! degree of pigmentation -intersection_of: inheres_in UBERON:0000061 ! anatomical structure -relationship: inheres_in UBERON:0000061 ! anatomical structure +intersection_of: RO:0000052 UBERON:0000061 ! inheres in anatomical structure +relationship: RO:0000052 UBERON:0000061 ! inheres in anatomical structure created_by: cjmungall creation_date: 2014-07-18T16:52:11Z @@ -159853,8 +259209,8 @@ synonym: "mass density of bone tissue" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0002481 ! bone tissue -relationship: inheres_in UBERON:0002481 ! bone tissue +intersection_of: RO:0000052 UBERON:0002481 ! inheres in bone tissue +relationship: RO:0000052 UBERON:0002481 ! inheres in bone tissue created_by: cjmungall creation_date: 2014-07-25T16:15:45Z @@ -159867,7 +259223,7 @@ synonym: "size of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000639 ! adrenal gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland created_by: cjmungall creation_date: 2014-07-27T01:19:14Z @@ -159880,7 +259236,7 @@ synonym: "size of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002100 ! tooth morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth created_by: cjmungall creation_date: 2014-07-27T01:19:07Z @@ -159893,7 +259249,7 @@ synonym: "size of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000112 ! tooth size is_a: OBA:VT0005358 ! incisor morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth created_by: cjmungall creation_date: 2014-07-27T01:19:11Z @@ -159906,8 +259262,8 @@ synonym: "orientation of axon terminus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in GO:0043679 ! axon terminus -relationship: inheres_in GO:0043679 ! axon terminus +intersection_of: RO:0000052 GO:0043679 ! inheres in axon terminus +relationship: RO:0000052 GO:0043679 ! inheres in axon terminus created_by: cjmungall creation_date: 2014-07-29T01:00:41Z @@ -159920,7 +259276,7 @@ synonym: "length of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003797 ! axon size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon created_by: cjmungall creation_date: 2014-07-29T01:00:44Z @@ -159933,8 +259289,8 @@ synonym: "located in of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0002261 ! located in intersection_of: PATO:0002261 ! located in -intersection_of: inheres_in GO:0030424 ! axon -relationship: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon +relationship: RO:0000052 GO:0030424 ! inheres in axon created_by: cjmungall creation_date: 2014-07-29T01:00:47Z @@ -159947,7 +259303,7 @@ synonym: "shape of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005404 ! axon morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon created_by: cjmungall creation_date: 2014-07-29T01:00:50Z @@ -159960,8 +259316,8 @@ synonym: "dendrite count trait" EXACT [GOC:TermGenie] is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0030425 ! dendrite -relationship: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite +relationship: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2014-07-29T01:00:53Z @@ -159974,7 +259330,7 @@ synonym: "thickness of dendrite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000123 ! dendrite size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2014-07-29T01:00:56Z @@ -159987,8 +259343,8 @@ synonym: "orientation of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in GO:0030424 ! axon -relationship: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon +relationship: RO:0000052 GO:0030424 ! inheres in axon created_by: cjmungall creation_date: 2014-07-29T01:00:59Z @@ -160001,8 +259357,8 @@ synonym: "orientation of dendrite" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in GO:0030425 ! dendrite -relationship: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite +relationship: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2014-07-29T01:01:02Z @@ -160015,7 +259371,7 @@ synonym: "shape of dendrite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015109 ! dendrite morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2014-07-29T01:01:05Z @@ -160028,7 +259384,7 @@ synonym: "size of dendrite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000051 ! cell projection size is_a: OBA:VT0015109 ! dendrite morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite created_by: cjmungall creation_date: 2014-07-29T01:01:08Z @@ -160042,7 +259398,7 @@ synonym: "blue of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000045 ! iris color is_a: PATO:0000318 ! blue intersection_of: PATO:0000318 ! blue -intersection_of: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris created_by: vasilevs creation_date: 2014-10-07T20:39:39Z @@ -160056,7 +259412,7 @@ synonym: "brown strand of hair  trait" EXACT [GOC:TermGenie] is_a: OBA:0002313 ! strand of hair color is_a: PATO:0000952 ! brown intersection_of: PATO:0000952 ! brown -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair created_by: vasilevs creation_date: 2014-10-07T20:41:50Z @@ -160069,9 +259425,9 @@ synonym: "length of dinoflagellate epicone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000057 ! cellular component size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0097613 ! dinoflagellate epicone +intersection_of: RO:0000052 GO:0097613 ! inheres in dinoflagellate epicone relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097613 ! dinoflagellate epicone +relationship: RO:0000052 GO:0097613 ! inheres in dinoflagellate epicone created_by: annethessen creation_date: 2014-12-02T18:49:09Z @@ -160084,9 +259440,9 @@ synonym: "length of dinoflagellate hypocone" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000057 ! cellular component size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0097614 ! dinoflagellate hypocone +intersection_of: RO:0000052 GO:0097614 ! inheres in dinoflagellate hypocone relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097614 ! dinoflagellate hypocone +relationship: RO:0000052 GO:0097614 ! inheres in dinoflagellate hypocone created_by: annethessen creation_date: 2014-12-02T18:53:16Z @@ -160099,9 +259455,9 @@ synonym: "eyespot apparatus color trait" EXACT [GOC:TermGenie] is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in GO:1990413 ! eyespot apparatus +intersection_of: RO:0000052 GO:1990413 ! inheres in eyespot apparatus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:1990413 ! eyespot apparatus +relationship: RO:0000052 GO:1990413 ! inheres in eyespot apparatus created_by: annethessen creation_date: 2014-12-02T19:04:56Z @@ -160114,7 +259470,7 @@ synonym: "color of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-12-02T19:42:39Z @@ -160128,7 +259484,7 @@ synonym: "nucleus diameter trait" EXACT [GOC:TermGenie] is_a: OBA:0000117 ! nuclear size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in GO:0005634 ! nucleus +intersection_of: RO:0000052 GO:0005634 ! inheres in nucleus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 created_by: annethessen creation_date: 2014-12-02T19:49:17Z @@ -160142,9 +259498,9 @@ synonym: "located in of eyespot apparatus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0002261 ! located in intersection_of: PATO:0002261 ! located in -intersection_of: inheres_in GO:1990413 ! eyespot apparatus +intersection_of: RO:0000052 GO:1990413 ! inheres in eyespot apparatus relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:1990413 ! eyespot apparatus +relationship: RO:0000052 GO:1990413 ! inheres in eyespot apparatus created_by: annethessen creation_date: 2014-12-04T14:56:06Z @@ -160156,9 +259512,9 @@ synonym: "dinoflagellate sulcal notch shape trait" EXACT [GOC:TermGenie] synonym: "shape of dinoflagellate sulcal notch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000093 ! dinoflagellate sulcus shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097618 ! dinoflagellate sulcal notch +intersection_of: RO:0000052 GO:0097618 ! inheres in dinoflagellate sulcal notch relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097618 ! dinoflagellate sulcal notch +relationship: RO:0000052 GO:0097618 ! inheres in dinoflagellate sulcal notch created_by: annethessen creation_date: 2014-12-10T15:43:23Z @@ -160171,9 +259527,9 @@ synonym: "shape of dinoflagellate apex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097683 ! dinoflagellate apex +intersection_of: RO:0000052 GO:0097683 ! inheres in dinoflagellate apex relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097683 ! dinoflagellate apex +relationship: RO:0000052 GO:0097683 ! inheres in dinoflagellate apex created_by: annethessen creation_date: 2014-12-19T19:29:50Z @@ -160186,9 +259542,9 @@ synonym: "shape of dinoflagellate antapex" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097684 ! dinoflagellate antapex +intersection_of: RO:0000052 GO:0097684 ! inheres in dinoflagellate antapex relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097684 ! dinoflagellate antapex +relationship: RO:0000052 GO:0097684 ! inheres in dinoflagellate antapex created_by: annethessen creation_date: 2014-12-19T19:31:27Z @@ -160200,9 +259556,9 @@ synonym: "dinoflagellate apical horn shape trait" EXACT [GOC:TermGenie] synonym: "shape of dinoflagellate apical horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000133 ! dinoflagellate apex shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097686 ! dinoflagellate apical horn +intersection_of: RO:0000052 GO:0097686 ! inheres in dinoflagellate apical horn relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097686 ! dinoflagellate apical horn +relationship: RO:0000052 GO:0097686 ! inheres in dinoflagellate apical horn created_by: annethessen creation_date: 2014-12-22T19:25:15Z @@ -160214,9 +259570,9 @@ synonym: "dinoflagellate antapical horn shape trait" EXACT [GOC:TermGenie] synonym: "shape of dinoflagellate antapical horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000134 ! dinoflagellate antapex shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in GO:0097687 ! dinoflagellate antapical horn +intersection_of: RO:0000052 GO:0097687 ! inheres in dinoflagellate antapical horn relationship: dc-contributor http://orcid.org/0000-0002-2908-3327 -relationship: inheres_in GO:0097687 ! dinoflagellate antapical horn +relationship: RO:0000052 GO:0097687 ! inheres in dinoflagellate antapical horn created_by: annethessen creation_date: 2014-12-22T20:37:23Z @@ -160226,11 +259582,10 @@ name: endolymph volume def: "The volume of a endolymph." [AUTO:patterns/patterns/entity_attribute] synonym: "endolymph volume trait" EXACT [GOC:TermGenie] synonym: "volume of endolymph" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0100003 ! anatomical entity attribute -is_a: PATO:0000918 ! volume +is_a: OBA:0000036 ! body fluid levels intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001852 ! endolymph -relationship: inheres_in UBERON:0001852 ! endolymph +intersection_of: RO:0000052 UBERON:0001852 ! inheres in endolymph +relationship: RO:0000052 UBERON:0001852 ! inheres in endolymph created_by: cjmungall creation_date: 2015-01-11T01:04:32Z @@ -160243,7 +259598,7 @@ synonym: "size of bone element" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element created_by: cjmungall creation_date: 2015-03-03T00:34:47Z @@ -160256,8 +259611,8 @@ synonym: "skeletal joint flexibility trait" EXACT [GOC:TermGenie] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001543 ! flexibility intersection_of: PATO:0001543 ! flexibility -intersection_of: inheres_in UBERON:0000982 ! skeletal joint -relationship: inheres_in UBERON:0000982 ! skeletal joint +intersection_of: RO:0000052 UBERON:0000982 ! inheres in skeletal joint +relationship: RO:0000052 UBERON:0000982 ! inheres in skeletal joint created_by: cjmungall creation_date: 2015-03-03T16:41:59Z @@ -160269,8 +259624,8 @@ synonym: "epipubic bone size trait" EXACT [GOC:TermGenie] synonym: "size of epipubic bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002413 ! pelvic girdle bone/zone size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013204 ! epipubic bone -relationship: inheres_in UBERON:0013204 ! epipubic bone +intersection_of: RO:0000052 UBERON:0013204 ! inheres in epipubic bone +relationship: RO:0000052 UBERON:0013204 ! inheres in epipubic bone created_by: cjmungall creation_date: 2015-03-03T23:14:23Z @@ -160282,8 +259637,8 @@ synonym: "epipubic bone mass density trait" EXACT [GOC:TermGenie] synonym: "mass density of epipubic bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005007 ! bone mineral mass intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0013204 ! epipubic bone -relationship: inheres_in UBERON:0013204 ! epipubic bone +intersection_of: RO:0000052 UBERON:0013204 ! inheres in epipubic bone +relationship: RO:0000052 UBERON:0013204 ! inheres in epipubic bone created_by: cjmungall creation_date: 2015-03-03T23:14:26Z @@ -160296,8 +259651,8 @@ synonym: "vesicle size trait" EXACT [GOC:TermGenie] is_a: OBA:0000057 ! cellular component size is_a: OBA:1000078 ! attribute of organelle intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0031982 ! vesicle -relationship: inheres_in GO:0031982 ! vesicle +intersection_of: RO:0000052 GO:0031982 ! inheres in vesicle +relationship: RO:0000052 GO:0031982 ! inheres in vesicle created_by: cjmungall creation_date: 2015-04-14T22:09:46Z @@ -160310,7 +259665,7 @@ synonym: "size of lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001879 ! lymphatic vessel morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel created_by: cjmungall creation_date: 2015-04-14T22:09:50Z @@ -160323,7 +259678,7 @@ synonym: "permeability of lymphatic vessel" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0000174 ! vascular permeability is_a: OBA:VT0001879 ! lymphatic vessel morphology trait intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel created_by: cjmungall creation_date: 2015-04-14T22:09:54Z @@ -160335,8 +259690,8 @@ synonym: "lymphatic vessel quality trait" EXACT [GOC:TermGenie] synonym: "quality of lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel -relationship: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel +relationship: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel created_by: cjmungall creation_date: 2015-04-14T22:09:58Z @@ -160348,8 +259703,8 @@ synonym: "endoplasmic reticulum membrane permeability trait" EXACT [GOC:TermGeni synonym: "permeability of endoplasmic reticulum membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000028 ! membrane permeability intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in GO:0005789 ! endoplasmic reticulum membrane -relationship: inheres_in GO:0005789 ! endoplasmic reticulum membrane +intersection_of: RO:0000052 GO:0005789 ! inheres in endoplasmic reticulum membrane +relationship: RO:0000052 GO:0005789 ! inheres in endoplasmic reticulum membrane created_by: cjmungall creation_date: 2015-09-29T15:36:19Z @@ -160360,8 +259715,8 @@ def: "The quality of a subungual region." [AUTO:patterns/patterns/entity_attribu synonym: "quality of subungual region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004105 ! subungual region -relationship: inheres_in UBERON:0004105 ! subungual region +intersection_of: RO:0000052 UBERON:0004105 ! inheres in subungual region +relationship: RO:0000052 UBERON:0004105 ! inheres in subungual region [Term] id: OBA:1000148 @@ -160370,8 +259725,8 @@ def: "The quality of a proximal epiphysis of tibia." [AUTO:patterns/patterns/ent synonym: "quality of proximal epiphysis of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008772 ! proximal epiphysis of tibia -relationship: inheres_in UBERON:0008772 ! proximal epiphysis of tibia +intersection_of: RO:0000052 UBERON:0008772 ! inheres in proximal epiphysis of tibia +relationship: RO:0000052 UBERON:0008772 ! inheres in proximal epiphysis of tibia [Term] id: OBA:1000149 @@ -160380,8 +259735,8 @@ def: "The quality of a alimentary part of gastrointestinal system." [AUTO:patter synonym: "quality of alimentary part of gastrointestinal system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system -relationship: inheres_in UBERON:0005409 ! alimentary part of gastrointestinal system +intersection_of: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system +relationship: RO:0000052 UBERON:0005409 ! inheres in alimentary part of gastrointestinal system [Term] id: OBA:1000150 @@ -160390,8 +259745,8 @@ def: "The quality of a proximal phalanx of manual digit 5." [AUTO:patterns/patte synonym: "quality of proximal phalanx of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000610 ! proximal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 -relationship: inheres_in UBERON:0004331 ! proximal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 +relationship: RO:0000052 UBERON:0004331 ! inheres in proximal phalanx of manual digit 5 [Term] id: OBA:1000151 @@ -160400,8 +259755,8 @@ def: "The quality of a liposaccharide metabolic process." [AUTO:patterns/pattern synonym: "quality of liposaccharide metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903509 ! liposaccharide metabolic process -relationship: inheres_in GO:1903509 ! liposaccharide metabolic process +intersection_of: RO:0000052 GO:1903509 ! inheres in liposaccharide metabolic process +relationship: RO:0000052 GO:1903509 ! inheres in liposaccharide metabolic process [Term] id: OBA:1000152 @@ -160410,8 +259765,8 @@ def: "The quality of a pyrimidine nucleobase metabolic process." [AUTO:patterns/ synonym: "quality of pyrimidine nucleobase metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006206 ! pyrimidine nucleobase metabolic process -relationship: inheres_in GO:0006206 ! pyrimidine nucleobase metabolic process +intersection_of: RO:0000052 GO:0006206 ! inheres in pyrimidine nucleobase metabolic process +relationship: RO:0000052 GO:0006206 ! inheres in pyrimidine nucleobase metabolic process [Term] id: OBA:1000153 @@ -160420,8 +259775,8 @@ def: "The quality of a tryptophan metabolic process." [AUTO:patterns/patterns/en synonym: "quality of tryptophan metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000348 ! aromatic amino acid family metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006568 ! tryptophan metabolic process -relationship: inheres_in GO:0006568 ! tryptophan metabolic process +intersection_of: RO:0000052 GO:0006568 ! inheres in tryptophan metabolic process +relationship: RO:0000052 GO:0006568 ! inheres in tryptophan metabolic process [Term] id: OBA:1000154 @@ -160430,8 +259785,8 @@ def: "The quality of a ornithine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of ornithine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006591 ! ornithine metabolic process -relationship: inheres_in GO:0006591 ! ornithine metabolic process +intersection_of: RO:0000052 GO:0006591 ! inheres in ornithine metabolic process +relationship: RO:0000052 GO:0006591 ! inheres in ornithine metabolic process [Term] id: OBA:1000155 @@ -160440,8 +259795,8 @@ def: "The quality of a fatty acid metabolic process." [AUTO:patterns/patterns/en synonym: "quality of fatty acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000604 ! monocarboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006631 ! fatty acid metabolic process -relationship: inheres_in GO:0006631 ! fatty acid metabolic process +intersection_of: RO:0000052 GO:0006631 ! inheres in fatty acid metabolic process +relationship: RO:0000052 GO:0006631 ! inheres in fatty acid metabolic process [Term] id: OBA:1000156 @@ -160450,8 +259805,8 @@ def: "The quality of a vasculature of eye." [AUTO:patterns/patterns/entity_attri synonym: "quality of vasculature of eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002203 ! vasculature of eye -relationship: inheres_in UBERON:0002203 ! vasculature of eye +intersection_of: RO:0000052 UBERON:0002203 ! inheres in vasculature of eye +relationship: RO:0000052 UBERON:0002203 ! inheres in vasculature of eye [Term] id: OBA:1000157 @@ -160460,8 +259815,8 @@ def: "The quality of a interatrial septum." [AUTO:patterns/patterns/entity_attri synonym: "quality of interatrial septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000251 ! cardiac septum quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002085 ! interatrial septum -relationship: inheres_in UBERON:0002085 ! interatrial septum +intersection_of: RO:0000052 UBERON:0002085 ! inheres in interatrial septum +relationship: RO:0000052 UBERON:0002085 ! inheres in interatrial septum [Term] id: OBA:1000158 @@ -160470,8 +259825,8 @@ def: "The quality of a manual digit 4 phalanx." [AUTO:patterns/patterns/entity_a synonym: "quality of manual digit 4 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000632 ! phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003638 ! manual digit 4 phalanx -relationship: inheres_in UBERON:0003638 ! manual digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx +relationship: RO:0000052 UBERON:0003638 ! inheres in manual digit 4 phalanx [Term] id: OBA:1000159 @@ -160480,8 +259835,8 @@ def: "The quality of a greater sciatic notch." [AUTO:patterns/patterns/entity_at synonym: "quality of greater sciatic notch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0014411 ! greater sciatic notch -relationship: inheres_in UBERON:0014411 ! greater sciatic notch +intersection_of: RO:0000052 UBERON:0014411 ! inheres in greater sciatic notch +relationship: RO:0000052 UBERON:0014411 ! inheres in greater sciatic notch [Term] id: OBA:1000160 @@ -160490,8 +259845,8 @@ def: "The quality of a frontal process of maxilla." [AUTO:patterns/patterns/enti synonym: "quality of frontal process of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0013767 ! frontal process of maxilla -relationship: inheres_in UBERON:0013767 ! frontal process of maxilla +intersection_of: RO:0000052 UBERON:0013767 ! inheres in frontal process of maxilla +relationship: RO:0000052 UBERON:0013767 ! inheres in frontal process of maxilla [Term] id: OBA:1000161 @@ -160500,8 +259855,8 @@ def: "The quality of a pedal digit 1 phalanx." [AUTO:patterns/patterns/entity_at synonym: "quality of pedal digit 1 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003640 ! pedal digit 1 phalanx -relationship: inheres_in UBERON:0003640 ! pedal digit 1 phalanx +intersection_of: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx +relationship: RO:0000052 UBERON:0003640 ! inheres in pedal digit 1 phalanx [Term] id: OBA:1000162 @@ -160510,8 +259865,8 @@ def: "The quality of a sphenoidal sinus." [AUTO:patterns/patterns/entity_attribu synonym: "quality of sphenoidal sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000172 ! paranasal sinus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001724 ! sphenoidal sinus -relationship: inheres_in UBERON:0001724 ! sphenoidal sinus +intersection_of: RO:0000052 UBERON:0001724 ! inheres in sphenoidal sinus +relationship: RO:0000052 UBERON:0001724 ! inheres in sphenoidal sinus [Term] id: OBA:1000163 @@ -160520,8 +259875,8 @@ def: "The quality of a philtrum." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of philtrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015052 ! surface structure trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005402 ! philtrum -relationship: inheres_in UBERON:0005402 ! philtrum +intersection_of: RO:0000052 UBERON:0005402 ! inheres in philtrum +relationship: RO:0000052 UBERON:0005402 ! inheres in philtrum [Term] id: OBA:1000164 @@ -160530,8 +259885,8 @@ def: "The quality of a musculature of pharynx." [AUTO:patterns/patterns/entity_a synonym: "quality of musculature of pharynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004467 ! musculature of pharynx -relationship: inheres_in UBERON:0004467 ! musculature of pharynx +intersection_of: RO:0000052 UBERON:0004467 ! inheres in musculature of pharynx +relationship: RO:0000052 UBERON:0004467 ! inheres in musculature of pharynx [Term] id: OBA:1000165 @@ -160540,8 +259895,8 @@ def: "The quality of a orotic acid metabolic process." [AUTO:patterns/patterns/e synonym: "quality of orotic acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000604 ! monocarboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903511 ! orotic acid metabolic process -relationship: inheres_in GO:1903511 ! orotic acid metabolic process +intersection_of: RO:0000052 GO:1903511 ! inheres in orotic acid metabolic process +relationship: RO:0000052 GO:1903511 ! inheres in orotic acid metabolic process [Term] id: OBA:1000166 @@ -160550,8 +259905,8 @@ def: "The quality of a cerebrospinal fluid." [AUTO:patterns/patterns/entity_attr synonym: "quality of cerebrospinal fluid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001359 ! cerebrospinal fluid -relationship: inheres_in UBERON:0001359 ! cerebrospinal fluid +intersection_of: RO:0000052 UBERON:0001359 ! inheres in cerebrospinal fluid +relationship: RO:0000052 UBERON:0001359 ! inheres in cerebrospinal fluid [Term] id: OBA:1000167 @@ -160560,8 +259915,8 @@ def: "The quality of a glycine metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of glycine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000220 ! serine family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006544 ! glycine metabolic process -relationship: inheres_in GO:0006544 ! glycine metabolic process +intersection_of: RO:0000052 GO:0006544 ! inheres in glycine metabolic process +relationship: RO:0000052 GO:0006544 ! inheres in glycine metabolic process [Term] id: OBA:1000168 @@ -160570,8 +259925,8 @@ def: "The quality of a cerebral artery." [AUTO:patterns/patterns/entity_attribut synonym: "quality of cerebral artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004449 ! cerebral artery -relationship: inheres_in UBERON:0004449 ! cerebral artery +intersection_of: RO:0000052 UBERON:0004449 ! inheres in cerebral artery +relationship: RO:0000052 UBERON:0004449 ! inheres in cerebral artery [Term] id: OBA:1000169 @@ -160580,8 +259935,8 @@ def: "The quality of a cortex of kidney." [AUTO:patterns/patterns/entity_attribu synonym: "quality of cortex of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001225 ! cortex of kidney -relationship: inheres_in UBERON:0001225 ! cortex of kidney +intersection_of: RO:0000052 UBERON:0001225 ! inheres in cortex of kidney +relationship: RO:0000052 UBERON:0001225 ! inheres in cortex of kidney [Term] id: OBA:1000170 @@ -160591,8 +259946,8 @@ synonym: "quality of proximal phalanx of pedal digit 2" EXACT [AUTO:patterns/pat is_a: OBA:1000212 ! proximal phalanx of pes quality is_a: OBA:1000353 ! pedal digit 2 phalanx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 -relationship: inheres_in UBERON:0004333 ! proximal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 +relationship: RO:0000052 UBERON:0004333 ! inheres in proximal phalanx of pedal digit 2 [Term] id: OBA:1000171 @@ -160601,8 +259956,8 @@ def: "The quality of a forelimb stylopod." [AUTO:patterns/patterns/entity_attrib synonym: "quality of forelimb stylopod" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003822 ! forelimb stylopod -relationship: inheres_in UBERON:0003822 ! forelimb stylopod +intersection_of: RO:0000052 UBERON:0003822 ! inheres in forelimb stylopod +relationship: RO:0000052 UBERON:0003822 ! inheres in forelimb stylopod [Term] id: OBA:1000172 @@ -160611,8 +259966,8 @@ def: "The quality of a paranasal sinus." [AUTO:patterns/patterns/entity_attribut synonym: "quality of paranasal sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001825 ! paranasal sinus -relationship: inheres_in UBERON:0001825 ! paranasal sinus +intersection_of: RO:0000052 UBERON:0001825 ! inheres in paranasal sinus +relationship: RO:0000052 UBERON:0001825 ! inheres in paranasal sinus [Term] id: OBA:1000173 @@ -160621,8 +259976,8 @@ def: "The quality of a risorius muscle." [AUTO:patterns/patterns/entity_attribut synonym: "quality of risorius muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008598 ! risorius muscle -relationship: inheres_in UBERON:0008598 ! risorius muscle +intersection_of: RO:0000052 UBERON:0008598 ! inheres in risorius muscle +relationship: RO:0000052 UBERON:0008598 ! inheres in risorius muscle [Term] id: OBA:1000174 @@ -160631,8 +259986,8 @@ def: "The quality of a uterine cervix." [AUTO:patterns/patterns/entity_attribute synonym: "quality of uterine cervix" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000002 ! uterine cervix -relationship: inheres_in UBERON:0000002 ! uterine cervix +intersection_of: RO:0000052 UBERON:0000002 ! inheres in uterine cervix +relationship: RO:0000052 UBERON:0000002 ! inheres in uterine cervix [Term] id: OBA:1000175 @@ -160642,8 +259997,8 @@ synonym: "quality of middle phalanx of pedal digit 5" EXACT [AUTO:patterns/patte is_a: OBA:1000329 ! pedal digit 5 phalanx quality is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004327 ! middle phalanx of pedal digit 5 -relationship: inheres_in UBERON:0004327 ! middle phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004327 ! inheres in middle phalanx of pedal digit 5 +relationship: RO:0000052 UBERON:0004327 ! inheres in middle phalanx of pedal digit 5 [Term] id: OBA:1000176 @@ -160652,8 +260007,8 @@ def: "The quality of a celiac artery." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of celiac artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001640 ! celiac artery -relationship: inheres_in UBERON:0001640 ! celiac artery +intersection_of: RO:0000052 UBERON:0001640 ! inheres in celiac artery +relationship: RO:0000052 UBERON:0001640 ! inheres in celiac artery [Term] id: OBA:1000177 @@ -160662,8 +260017,8 @@ def: "The quality of a ilium." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ilium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001273 ! ilium -relationship: inheres_in UBERON:0001273 ! ilium +intersection_of: RO:0000052 UBERON:0001273 ! inheres in ilium +relationship: RO:0000052 UBERON:0001273 ! inheres in ilium [Term] id: OBA:1000178 @@ -160672,8 +260027,8 @@ def: "The quality of a proximal phalanx of manual digit 3." [AUTO:patterns/patte synonym: "quality of proximal phalanx of manual digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000610 ! proximal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 -relationship: inheres_in UBERON:0004329 ! proximal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 +relationship: RO:0000052 UBERON:0004329 ! inheres in proximal phalanx of manual digit 3 [Term] id: OBA:1000179 @@ -160682,8 +260037,8 @@ def: "The quality of a mast cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of mast cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000097 ! mast cell -relationship: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell +relationship: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:1000180 @@ -160692,8 +260047,8 @@ def: "The quality of a distal epiphysis of femur." [AUTO:patterns/patterns/entit synonym: "quality of distal epiphysis of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004406 ! distal epiphysis of femur -relationship: inheres_in UBERON:0004406 ! distal epiphysis of femur +intersection_of: RO:0000052 UBERON:0004406 ! inheres in distal epiphysis of femur +relationship: RO:0000052 UBERON:0004406 ! inheres in distal epiphysis of femur [Term] id: OBA:1000181 @@ -160702,8 +260057,8 @@ def: "The quality of a lateral crico-arytenoid." [AUTO:patterns/patterns/entity_ synonym: "quality of lateral crico-arytenoid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008573 ! lateral crico-arytenoid -relationship: inheres_in UBERON:0008573 ! lateral crico-arytenoid +intersection_of: RO:0000052 UBERON:0008573 ! inheres in lateral crico-arytenoid +relationship: RO:0000052 UBERON:0008573 ! inheres in lateral crico-arytenoid [Term] id: OBA:1000182 @@ -160712,8 +260067,8 @@ def: "The quality of a Leydig cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of Leydig cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000178 ! Leydig cell -relationship: inheres_in CL:0000178 ! Leydig cell +intersection_of: RO:0000052 CL:0000178 ! inheres in Leydig cell +relationship: RO:0000052 CL:0000178 ! inheres in Leydig cell [Term] id: OBA:1000183 @@ -160722,8 +260077,8 @@ def: "The quality of a epiphysis of phalanx of manus." [AUTO:patterns/patterns/e synonym: "quality of epiphysis of phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus -relationship: inheres_in UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus +relationship: RO:0000052 UBERON:0004387 ! inheres in epiphysis of phalanx of manus [Term] id: OBA:1000184 @@ -160732,8 +260087,8 @@ def: "The quality of a biliary tree." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of biliary tree" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001173 ! biliary tree -relationship: inheres_in UBERON:0001173 ! biliary tree +intersection_of: RO:0000052 UBERON:0001173 ! inheres in biliary tree +relationship: RO:0000052 UBERON:0001173 ! inheres in biliary tree [Term] id: OBA:1000185 @@ -160742,8 +260097,8 @@ def: "The quality of a striatum." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of striatum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002435 ! striatum -relationship: inheres_in UBERON:0002435 ! striatum +intersection_of: RO:0000052 UBERON:0002435 ! inheres in striatum +relationship: RO:0000052 UBERON:0002435 ! inheres in striatum [Term] id: OBA:1000186 @@ -160753,8 +260108,8 @@ synonym: "quality of malleus bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:1000265 ! auditory ossicle bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001689 ! malleus bone -relationship: inheres_in UBERON:0001689 ! malleus bone +intersection_of: RO:0000052 UBERON:0001689 ! inheres in malleus bone +relationship: RO:0000052 UBERON:0001689 ! inheres in malleus bone [Term] id: OBA:1000187 @@ -160763,8 +260118,8 @@ def: "The quality of a genital labium." [AUTO:patterns/patterns/entity_attribute synonym: "quality of genital labium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004084 ! genital labium -relationship: inheres_in UBERON:0004084 ! genital labium +intersection_of: RO:0000052 UBERON:0004084 ! inheres in genital labium +relationship: RO:0000052 UBERON:0004084 ! inheres in genital labium [Term] id: OBA:1000188 @@ -160773,8 +260128,8 @@ def: "The quality of a gingiva." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of gingiva" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000401 ! mouth mucosa quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001828 ! gingiva -relationship: inheres_in UBERON:0001828 ! gingiva +intersection_of: RO:0000052 UBERON:0001828 ! inheres in gingiva +relationship: RO:0000052 UBERON:0001828 ! inheres in gingiva [Term] id: OBA:1000189 @@ -160783,8 +260138,8 @@ def: "The quality of a navicular bone of pes." [AUTO:patterns/patterns/entity_at synonym: "quality of navicular bone of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000508 ! tarsal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001451 ! navicular bone of pes -relationship: inheres_in UBERON:0001451 ! navicular bone of pes +intersection_of: RO:0000052 UBERON:0001451 ! inheres in navicular bone of pes +relationship: RO:0000052 UBERON:0001451 ! inheres in navicular bone of pes [Term] id: OBA:1000190 @@ -160793,8 +260148,8 @@ def: "The quality of a distal phalanx of manus." [AUTO:patterns/patterns/entity_ synonym: "quality of distal phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000632 ! phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003865 ! distal phalanx of manus -relationship: inheres_in UBERON:0003865 ! distal phalanx of manus +intersection_of: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus +relationship: RO:0000052 UBERON:0003865 ! inheres in distal phalanx of manus [Term] id: OBA:1000191 @@ -160803,8 +260158,8 @@ def: "The quality of a pedal digit 2." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pedal digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003632 ! pedal digit 2 -relationship: inheres_in UBERON:0003632 ! pedal digit 2 +intersection_of: RO:0000052 UBERON:0003632 ! inheres in pedal digit 2 +relationship: RO:0000052 UBERON:0003632 ! inheres in pedal digit 2 [Term] id: OBA:1000192 @@ -160813,8 +260168,8 @@ def: "The quality of a periosteum." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of periosteum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002515 ! periosteum -relationship: inheres_in UBERON:0002515 ! periosteum +intersection_of: RO:0000052 UBERON:0002515 ! inheres in periosteum +relationship: RO:0000052 UBERON:0002515 ! inheres in periosteum [Term] id: OBA:1000193 @@ -160823,8 +260178,8 @@ def: "The quality of a somatic nervous system." [AUTO:patterns/patterns/entity_a synonym: "quality of somatic nervous system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000012 ! somatic nervous system -relationship: inheres_in UBERON:0000012 ! somatic nervous system +intersection_of: RO:0000052 UBERON:0000012 ! inheres in somatic nervous system +relationship: RO:0000052 UBERON:0000012 ! inheres in somatic nervous system [Term] id: OBA:1000194 @@ -160833,8 +260188,8 @@ def: "The quality of a glutamine family amino acid metabolic process." [AUTO:pat synonym: "quality of glutamine family amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009064 ! glutamine family amino acid metabolic process -relationship: inheres_in GO:0009064 ! glutamine family amino acid metabolic process +intersection_of: RO:0000052 GO:0009064 ! inheres in glutamine family amino acid metabolic process +relationship: RO:0000052 GO:0009064 ! inheres in glutamine family amino acid metabolic process [Term] id: OBA:1000195 @@ -160843,8 +260198,8 @@ def: "The quality of a corneal endothelium." [AUTO:patterns/patterns/entity_attr synonym: "quality of corneal endothelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001985 ! corneal endothelium -relationship: inheres_in UBERON:0001985 ! corneal endothelium +intersection_of: RO:0000052 UBERON:0001985 ! inheres in corneal endothelium +relationship: RO:0000052 UBERON:0001985 ! inheres in corneal endothelium [Term] id: OBA:1000196 @@ -160853,8 +260208,8 @@ def: "The quality of a distal epiphysis of tibia." [AUTO:patterns/patterns/entit synonym: "quality of distal epiphysis of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004405 ! distal epiphysis of tibia -relationship: inheres_in UBERON:0004405 ! distal epiphysis of tibia +intersection_of: RO:0000052 UBERON:0004405 ! inheres in distal epiphysis of tibia +relationship: RO:0000052 UBERON:0004405 ! inheres in distal epiphysis of tibia [Term] id: OBA:1000197 @@ -160863,8 +260218,8 @@ def: "The quality of a eye movement." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of eye movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000678 ! body part movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000444 ! eye movement -relationship: inheres_in NBO:0000444 ! eye movement +intersection_of: RO:0000052 NBO:0000444 ! inheres in eye movement +relationship: RO:0000052 NBO:0000444 ! inheres in eye movement [Term] id: OBA:1000198 @@ -160873,8 +260228,8 @@ def: "The quality of a vestibular nerve." [AUTO:patterns/patterns/entity_attribu synonym: "quality of vestibular nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003723 ! vestibular nerve -relationship: inheres_in UBERON:0003723 ! vestibular nerve +intersection_of: RO:0000052 UBERON:0003723 ! inheres in vestibular nerve +relationship: RO:0000052 UBERON:0003723 ! inheres in vestibular nerve [Term] id: OBA:1000199 @@ -160883,8 +260238,8 @@ def: "The quality of a von Willebrand factor." [AUTO:patterns/patterns/entity_at synonym: "quality of von Willebrand factor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100005 ! protein attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PR:000017364 ! von Willebrand factor -relationship: inheres_in PR:000017364 ! von Willebrand factor +intersection_of: RO:0000052 PR:000017364 ! inheres in von Willebrand factor +relationship: RO:0000052 PR:000017364 ! inheres in von Willebrand factor [Term] id: OBA:1000200 @@ -160895,8 +260250,8 @@ is_a: OBA:1000246 ! neck blood vessel quality is_a: OBA:1000292 ! vein quality is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001653 ! facial vein -relationship: inheres_in UBERON:0001653 ! facial vein +intersection_of: RO:0000052 UBERON:0001653 ! inheres in facial vein +relationship: RO:0000052 UBERON:0001653 ! inheres in facial vein [Term] id: OBA:1000201 @@ -160905,8 +260260,8 @@ def: "The quality of a mitochondrial respirasome." [AUTO:patterns/patterns/entit synonym: "quality of mitochondrial respirasome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005746 ! mitochondrial respirasome -relationship: inheres_in GO:0005746 ! mitochondrial respirasome +intersection_of: RO:0000052 GO:0005746 ! inheres in mitochondrial respirasome +relationship: RO:0000052 GO:0005746 ! inheres in mitochondrial respirasome [Term] id: OBA:1000202 @@ -160915,8 +260270,8 @@ def: "The quality of a cartilage of external ear." [AUTO:patterns/patterns/entit synonym: "quality of cartilage of external ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001867 ! cartilage of external ear -relationship: inheres_in UBERON:0001867 ! cartilage of external ear +intersection_of: RO:0000052 UBERON:0001867 ! inheres in cartilage of external ear +relationship: RO:0000052 UBERON:0001867 ! inheres in cartilage of external ear [Term] id: OBA:1000203 @@ -160925,8 +260280,8 @@ def: "The quality of a cranial ganglion." [AUTO:patterns/patterns/entity_attribu synonym: "quality of cranial ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000529 ! ganglion quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001714 ! cranial ganglion -relationship: inheres_in UBERON:0001714 ! cranial ganglion +intersection_of: RO:0000052 UBERON:0001714 ! inheres in cranial ganglion +relationship: RO:0000052 UBERON:0001714 ! inheres in cranial ganglion [Term] id: OBA:1000204 @@ -160936,8 +260291,8 @@ synonym: "quality of proximal phalanx of manual digit 4" EXACT [AUTO:patterns/pa is_a: OBA:1000158 ! manual digit 4 phalanx quality is_a: OBA:1000610 ! proximal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 -relationship: inheres_in UBERON:0004330 ! proximal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 +relationship: RO:0000052 UBERON:0004330 ! inheres in proximal phalanx of manual digit 4 [Term] id: OBA:1000205 @@ -160946,8 +260301,8 @@ def: "The quality of a synovial joint." [AUTO:patterns/patterns/entity_attribute synonym: "quality of synovial joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002217 ! synovial joint -relationship: inheres_in UBERON:0002217 ! synovial joint +intersection_of: RO:0000052 UBERON:0002217 ! inheres in synovial joint +relationship: RO:0000052 UBERON:0002217 ! inheres in synovial joint [Term] id: OBA:1000206 @@ -160956,8 +260311,8 @@ def: "The quality of a dentate nucleus." [AUTO:patterns/patterns/entity_attribut synonym: "quality of dentate nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002132 ! dentate nucleus -relationship: inheres_in UBERON:0002132 ! dentate nucleus +intersection_of: RO:0000052 UBERON:0002132 ! inheres in dentate nucleus +relationship: RO:0000052 UBERON:0002132 ! inheres in dentate nucleus [Term] id: OBA:1000207 @@ -160966,8 +260321,8 @@ def: "The quality of a levator veli palatini." [AUTO:patterns/patterns/entity_at synonym: "quality of levator veli palatini" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008585 ! levator veli palatini -relationship: inheres_in UBERON:0008585 ! levator veli palatini +intersection_of: RO:0000052 UBERON:0008585 ! inheres in levator veli palatini +relationship: RO:0000052 UBERON:0008585 ! inheres in levator veli palatini [Term] id: OBA:1000208 @@ -160977,8 +260332,8 @@ synonym: "quality of middle phalanx of manual digit 4" EXACT [AUTO:patterns/patt is_a: OBA:1000158 ! manual digit 4 phalanx quality is_a: OBA:1000382 ! middle phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 -relationship: inheres_in UBERON:0004322 ! middle phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 +relationship: RO:0000052 UBERON:0004322 ! inheres in middle phalanx of manual digit 4 [Term] id: OBA:1000209 @@ -160987,8 +260342,8 @@ def: "The quality of a spinal cord dorsal column." [AUTO:patterns/patterns/entit synonym: "quality of spinal cord dorsal column" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005373 ! spinal cord dorsal column -relationship: inheres_in UBERON:0005373 ! spinal cord dorsal column +intersection_of: RO:0000052 UBERON:0005373 ! inheres in spinal cord dorsal column +relationship: RO:0000052 UBERON:0005373 ! inheres in spinal cord dorsal column [Term] id: OBA:1000210 @@ -160997,8 +260352,8 @@ def: "The quality of a distal phalanx of manual digit 3." [AUTO:patterns/pattern synonym: "quality of distal phalanx of manual digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000190 ! distal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 -relationship: inheres_in UBERON:0004312 ! distal phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 +relationship: RO:0000052 UBERON:0004312 ! inheres in distal phalanx of manual digit 3 [Term] id: OBA:1000211 @@ -161007,8 +260362,8 @@ def: "The quality of a cranial suture." [AUTO:patterns/patterns/entity_attribute synonym: "quality of cranial suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003685 ! cranial suture -relationship: inheres_in UBERON:0003685 ! cranial suture +intersection_of: RO:0000052 UBERON:0003685 ! inheres in cranial suture +relationship: RO:0000052 UBERON:0003685 ! inheres in cranial suture [Term] id: OBA:1000212 @@ -161017,8 +260372,8 @@ def: "The quality of a proximal phalanx of pes." [AUTO:patterns/patterns/entity_ synonym: "quality of proximal phalanx of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003868 ! proximal phalanx of pes -relationship: inheres_in UBERON:0003868 ! proximal phalanx of pes +intersection_of: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes +relationship: RO:0000052 UBERON:0003868 ! inheres in proximal phalanx of pes [Term] id: OBA:1000213 @@ -161027,8 +260382,8 @@ def: "The quality of a female reproductive system." [AUTO:patterns/patterns/enti synonym: "quality of female reproductive system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005389 ! reproductive system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000474 ! female reproductive system -relationship: inheres_in UBERON:0000474 ! female reproductive system +intersection_of: RO:0000052 UBERON:0000474 ! inheres in female reproductive system +relationship: RO:0000052 UBERON:0000474 ! inheres in female reproductive system [Term] id: OBA:1000214 @@ -161037,8 +260392,8 @@ def: "The quality of a palatoglossus muscle." [AUTO:patterns/patterns/entity_att synonym: "quality of palatoglossus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000261 ! tongue muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001574 ! palatoglossus muscle -relationship: inheres_in UBERON:0001574 ! palatoglossus muscle +intersection_of: RO:0000052 UBERON:0001574 ! inheres in palatoglossus muscle +relationship: RO:0000052 UBERON:0001574 ! inheres in palatoglossus muscle [Term] id: OBA:1000215 @@ -161048,8 +260403,8 @@ synonym: "quality of proximal phalanx of pedal digit 4" EXACT [AUTO:patterns/pat is_a: OBA:1000212 ! proximal phalanx of pes quality is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004335 ! proximal phalanx of pedal digit 4 -relationship: inheres_in UBERON:0004335 ! proximal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004335 ! inheres in proximal phalanx of pedal digit 4 +relationship: RO:0000052 UBERON:0004335 ! inheres in proximal phalanx of pedal digit 4 [Term] id: OBA:1000216 @@ -161058,8 +260413,8 @@ def: "The quality of a metacarpophalangeal joint." [AUTO:patterns/patterns/entit synonym: "quality of metacarpophalangeal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003695 ! metacarpophalangeal joint -relationship: inheres_in UBERON:0003695 ! metacarpophalangeal joint +intersection_of: RO:0000052 UBERON:0003695 ! inheres in metacarpophalangeal joint +relationship: RO:0000052 UBERON:0003695 ! inheres in metacarpophalangeal joint [Term] id: OBA:1000217 @@ -161068,8 +260423,8 @@ def: "The quality of a depressor labii inferioris." [AUTO:patterns/patterns/enti synonym: "quality of depressor labii inferioris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001581 ! depressor labii inferioris -relationship: inheres_in UBERON:0001581 ! depressor labii inferioris +intersection_of: RO:0000052 UBERON:0001581 ! inheres in depressor labii inferioris +relationship: RO:0000052 UBERON:0001581 ! inheres in depressor labii inferioris [Term] id: OBA:1000218 @@ -161078,8 +260433,8 @@ def: "The quality of a nasal hair." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of nasal hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000405 ! hair of head quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011931 ! nasal hair -relationship: inheres_in UBERON:0011931 ! nasal hair +intersection_of: RO:0000052 UBERON:0011931 ! inheres in nasal hair +relationship: RO:0000052 UBERON:0011931 ! inheres in nasal hair [Term] id: OBA:1000219 @@ -161088,8 +260443,8 @@ def: "The quality of a agitation behavior." [AUTO:patterns/patterns/entity_attri synonym: "quality of agitation behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000129 ! agitation behavior -relationship: inheres_in NBO:0000129 ! agitation behavior +intersection_of: RO:0000052 NBO:0000129 ! inheres in agitation behavior +relationship: RO:0000052 NBO:0000129 ! inheres in agitation behavior [Term] id: OBA:1000220 @@ -161098,8 +260453,8 @@ def: "The quality of a serine family amino acid metabolic process." [AUTO:patter synonym: "quality of serine family amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009069 ! serine family amino acid metabolic process -relationship: inheres_in GO:0009069 ! serine family amino acid metabolic process +intersection_of: RO:0000052 GO:0009069 ! inheres in serine family amino acid metabolic process +relationship: RO:0000052 GO:0009069 ! inheres in serine family amino acid metabolic process [Term] id: OBA:1000221 @@ -161108,8 +260463,8 @@ def: "The quality of a epiphysis of metatarsal bone." [AUTO:patterns/patterns/en synonym: "quality of epiphysis of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004389 ! epiphysis of metatarsal bone -relationship: inheres_in UBERON:0004389 ! epiphysis of metatarsal bone +intersection_of: RO:0000052 UBERON:0004389 ! inheres in epiphysis of metatarsal bone +relationship: RO:0000052 UBERON:0004389 ! inheres in epiphysis of metatarsal bone [Term] id: OBA:1000222 @@ -161118,8 +260473,8 @@ def: "The quality of a mentalis muscle." [AUTO:patterns/patterns/entity_attribut synonym: "quality of mentalis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008596 ! mentalis muscle -relationship: inheres_in UBERON:0008596 ! mentalis muscle +intersection_of: RO:0000052 UBERON:0008596 ! inheres in mentalis muscle +relationship: RO:0000052 UBERON:0008596 ! inheres in mentalis muscle [Term] id: OBA:1000223 @@ -161128,8 +260483,8 @@ def: "The quality of a mucopolysaccharide metabolic process." [AUTO:patterns/pat synonym: "quality of mucopolysaccharide metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903510 ! mucopolysaccharide metabolic process -relationship: inheres_in GO:1903510 ! mucopolysaccharide metabolic process +intersection_of: RO:0000052 GO:1903510 ! inheres in mucopolysaccharide metabolic process +relationship: RO:0000052 GO:1903510 ! inheres in mucopolysaccharide metabolic process [Term] id: OBA:1000224 @@ -161138,8 +260493,8 @@ def: "The quality of a falx cerebri." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of falx cerebri" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006059 ! falx cerebri -relationship: inheres_in UBERON:0006059 ! falx cerebri +intersection_of: RO:0000052 UBERON:0006059 ! inheres in falx cerebri +relationship: RO:0000052 UBERON:0006059 ! inheres in falx cerebri [Term] id: OBA:1000225 @@ -161148,8 +260503,8 @@ def: "The quality of a fear/anxiety related behavior." [AUTO:patterns/patterns/e synonym: "quality of fear/anxiety related behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000018 ! fear/anxiety related behavior -relationship: inheres_in NBO:0000018 ! fear/anxiety related behavior +intersection_of: RO:0000052 NBO:0000018 ! inheres in fear/anxiety related behavior +relationship: RO:0000052 NBO:0000018 ! inheres in fear/anxiety related behavior [Term] id: OBA:1000226 @@ -161158,8 +260513,8 @@ def: "The quality of a peripheral nervous system." [AUTO:patterns/patterns/entit synonym: "quality of peripheral nervous system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000010 ! peripheral nervous system -relationship: inheres_in UBERON:0000010 ! peripheral nervous system +intersection_of: RO:0000052 UBERON:0000010 ! inheres in peripheral nervous system +relationship: RO:0000052 UBERON:0000010 ! inheres in peripheral nervous system [Term] id: OBA:1000227 @@ -161168,8 +260523,8 @@ def: "The quality of a lens of camera-type eye." [AUTO:patterns/patterns/entity_ synonym: "quality of lens of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye -relationship: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye +relationship: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:1000228 @@ -161178,8 +260533,8 @@ def: "The quality of a proximal phalanx of manual digit 2." [AUTO:patterns/patte synonym: "quality of proximal phalanx of manual digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000610 ! proximal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 -relationship: inheres_in UBERON:0004328 ! proximal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 +relationship: RO:0000052 UBERON:0004328 ! inheres in proximal phalanx of manual digit 2 [Term] id: OBA:1000229 @@ -161188,8 +260543,8 @@ def: "The quality of a heart left ventricle." [AUTO:patterns/patterns/entity_att synonym: "quality of heart left ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle -relationship: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle +relationship: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:1000230 @@ -161198,8 +260553,8 @@ def: "The quality of a artery of lower lip." [AUTO:patterns/patterns/entity_attr synonym: "quality of artery of lower lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003471 ! artery of lower lip -relationship: inheres_in UBERON:0003471 ! artery of lower lip +intersection_of: RO:0000052 UBERON:0003471 ! inheres in artery of lower lip +relationship: RO:0000052 UBERON:0003471 ! inheres in artery of lower lip [Term] id: OBA:1000231 @@ -161209,8 +260564,8 @@ synonym: "quality of homocysteine metabolic process" EXACT [AUTO:patterns/patter is_a: OBA:1000232 ! cellular amino acid metabolic process quality is_a: OBA:1000499 ! sulfur amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050667 ! homocysteine metabolic process -relationship: inheres_in GO:0050667 ! homocysteine metabolic process +intersection_of: RO:0000052 GO:0050667 ! inheres in homocysteine metabolic process +relationship: RO:0000052 GO:0050667 ! inheres in homocysteine metabolic process [Term] id: OBA:1000232 @@ -161219,8 +260574,8 @@ def: "The quality of a cellular amino acid metabolic process." [AUTO:patterns/pa synonym: "quality of cellular amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000583 ! carboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006520 ! cellular amino acid metabolic process -relationship: inheres_in GO:0006520 ! cellular amino acid metabolic process +intersection_of: RO:0000052 GO:0006520 ! inheres in cellular amino acid metabolic process +relationship: RO:0000052 GO:0006520 ! inheres in cellular amino acid metabolic process [Term] id: OBA:1000233 @@ -161229,8 +260584,8 @@ def: "The quality of a geniohyoid muscle." [AUTO:patterns/patterns/entity_attrib synonym: "quality of geniohyoid muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001565 ! geniohyoid muscle -relationship: inheres_in UBERON:0001565 ! geniohyoid muscle +intersection_of: RO:0000052 UBERON:0001565 ! inheres in geniohyoid muscle +relationship: RO:0000052 UBERON:0001565 ! inheres in geniohyoid muscle [Term] id: OBA:1000234 @@ -161240,8 +260595,8 @@ synonym: "quality of incus bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:1000265 ! auditory ossicle bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001688 ! incus bone -relationship: inheres_in UBERON:0001688 ! incus bone +intersection_of: RO:0000052 UBERON:0001688 ! inheres in incus bone +relationship: RO:0000052 UBERON:0001688 ! inheres in incus bone [Term] id: OBA:1000235 @@ -161250,8 +260605,8 @@ def: "The quality of a odontoid process of cervical vertebra 2." [AUTO:patterns/ synonym: "quality of odontoid process of cervical vertebra 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004096 ! odontoid process of cervical vertebra 2 -relationship: inheres_in UBERON:0004096 ! odontoid process of cervical vertebra 2 +intersection_of: RO:0000052 UBERON:0004096 ! inheres in odontoid process of cervical vertebra 2 +relationship: RO:0000052 UBERON:0004096 ! inheres in odontoid process of cervical vertebra 2 [Term] id: OBA:1000236 @@ -161260,8 +260615,8 @@ def: "The quality of a glial cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of glial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000125 ! glial cell -relationship: inheres_in CL:0000125 ! glial cell +intersection_of: RO:0000052 CL:0000125 ! inheres in glial cell +relationship: RO:0000052 CL:0000125 ! inheres in glial cell [Term] id: OBA:1000237 @@ -161270,8 +260625,8 @@ def: "The quality of a joint space of elbow." [AUTO:patterns/patterns/entity_att synonym: "quality of joint space of elbow" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004099 ! joint space of elbow -relationship: inheres_in UBERON:0004099 ! joint space of elbow +intersection_of: RO:0000052 UBERON:0004099 ! inheres in joint space of elbow +relationship: RO:0000052 UBERON:0004099 ! inheres in joint space of elbow [Term] id: OBA:1000238 @@ -161280,8 +260635,8 @@ def: "The quality of a oligodendrocyte." [AUTO:patterns/patterns/entity_attribut synonym: "quality of oligodendrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000236 ! glial cell quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000128 ! oligodendrocyte -relationship: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte +relationship: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:1000239 @@ -161290,8 +260645,8 @@ def: "The quality of a strand of pubic hair." [AUTO:patterns/patterns/entity_att synonym: "quality of strand of pubic hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0013698 ! strand of pubic hair -relationship: inheres_in UBERON:0013698 ! strand of pubic hair +intersection_of: RO:0000052 UBERON:0013698 ! inheres in strand of pubic hair +relationship: RO:0000052 UBERON:0013698 ! inheres in strand of pubic hair [Term] id: OBA:1000240 @@ -161301,8 +260656,8 @@ synonym: "quality of proximal phalanx of pedal digit 5" EXACT [AUTO:patterns/pat is_a: OBA:1000212 ! proximal phalanx of pes quality is_a: OBA:1000329 ! pedal digit 5 phalanx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004336 ! proximal phalanx of pedal digit 5 -relationship: inheres_in UBERON:0004336 ! proximal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004336 ! inheres in proximal phalanx of pedal digit 5 +relationship: RO:0000052 UBERON:0004336 ! inheres in proximal phalanx of pedal digit 5 [Term] id: OBA:1000241 @@ -161311,8 +260666,8 @@ def: "The quality of a anterior chamber of eyeball." [AUTO:patterns/patterns/ent synonym: "quality of anterior chamber of eyeball" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001766 ! anterior chamber of eyeball -relationship: inheres_in UBERON:0001766 ! anterior chamber of eyeball +intersection_of: RO:0000052 UBERON:0001766 ! inheres in anterior chamber of eyeball +relationship: RO:0000052 UBERON:0001766 ! inheres in anterior chamber of eyeball [Term] id: OBA:1000242 @@ -161326,8 +260681,8 @@ def: "The quality of a myeloid leukocyte." [AUTO:patterns/patterns/entity_attrib synonym: "quality of myeloid leukocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000766 ! myeloid leukocyte -relationship: inheres_in CL:0000766 ! myeloid leukocyte +intersection_of: RO:0000052 CL:0000766 ! inheres in myeloid leukocyte +relationship: RO:0000052 CL:0000766 ! inheres in myeloid leukocyte [Term] id: OBA:1000244 @@ -161336,8 +260691,8 @@ def: "The quality of a tonsil." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002372 ! tonsil -relationship: inheres_in UBERON:0002372 ! tonsil +intersection_of: RO:0000052 UBERON:0002372 ! inheres in tonsil +relationship: RO:0000052 UBERON:0002372 ! inheres in tonsil [Term] id: OBA:1000245 @@ -161346,8 +260701,8 @@ def: "The quality of a facial nerve." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of facial nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001647 ! facial nerve -relationship: inheres_in UBERON:0001647 ! facial nerve +intersection_of: RO:0000052 UBERON:0001647 ! inheres in facial nerve +relationship: RO:0000052 UBERON:0001647 ! inheres in facial nerve [Term] id: OBA:1000246 @@ -161356,8 +260711,8 @@ def: "The quality of a neck blood vessel." [AUTO:patterns/patterns/entity_attrib synonym: "quality of neck blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003502 ! neck blood vessel -relationship: inheres_in UBERON:0003502 ! neck blood vessel +intersection_of: RO:0000052 UBERON:0003502 ! inheres in neck blood vessel +relationship: RO:0000052 UBERON:0003502 ! inheres in neck blood vessel [Term] id: OBA:1000247 @@ -161366,8 +260721,8 @@ def: "The quality of a polysaccharide metabolic process." [AUTO:patterns/pattern synonym: "quality of polysaccharide metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000452 ! carbohydrate metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005976 ! polysaccharide metabolic process -relationship: inheres_in GO:0005976 ! polysaccharide metabolic process +intersection_of: RO:0000052 GO:0005976 ! inheres in polysaccharide metabolic process +relationship: RO:0000052 GO:0005976 ! inheres in polysaccharide metabolic process [Term] id: OBA:1000248 @@ -161376,8 +260731,8 @@ def: "The quality of a nasalis muscle." [AUTO:patterns/patterns/entity_attribute synonym: "quality of nasalis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010953 ! nasalis muscle -relationship: inheres_in UBERON:0010953 ! nasalis muscle +intersection_of: RO:0000052 UBERON:0010953 ! inheres in nasalis muscle +relationship: RO:0000052 UBERON:0010953 ! inheres in nasalis muscle [Term] id: OBA:1000249 @@ -161386,8 +260741,8 @@ def: "The quality of a basicranium." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of basicranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002517 ! basicranium -relationship: inheres_in UBERON:0002517 ! basicranium +intersection_of: RO:0000052 UBERON:0002517 ! inheres in basicranium +relationship: RO:0000052 UBERON:0002517 ! inheres in basicranium [Term] id: OBA:1000250 @@ -161396,8 +260751,8 @@ def: "The quality of a crus of ear." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of crus of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000202 ! cartilage of external ear quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004106 ! crus of ear -relationship: inheres_in UBERON:0004106 ! crus of ear +intersection_of: RO:0000052 UBERON:0004106 ! inheres in crus of ear +relationship: RO:0000052 UBERON:0004106 ! inheres in crus of ear [Term] id: OBA:1000251 @@ -161406,8 +260761,8 @@ def: "The quality of a cardiac septum." [AUTO:patterns/patterns/entity_attribute synonym: "quality of cardiac septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002099 ! cardiac septum -relationship: inheres_in UBERON:0002099 ! cardiac septum +intersection_of: RO:0000052 UBERON:0002099 ! inheres in cardiac septum +relationship: RO:0000052 UBERON:0002099 ! inheres in cardiac septum [Term] id: OBA:1000252 @@ -161417,8 +260772,8 @@ synonym: "quality of jugular vein" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000246 ! neck blood vessel quality is_a: OBA:1000292 ! vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004711 ! jugular vein -relationship: inheres_in UBERON:0004711 ! jugular vein +intersection_of: RO:0000052 UBERON:0004711 ! inheres in jugular vein +relationship: RO:0000052 UBERON:0004711 ! inheres in jugular vein [Term] id: OBA:1000253 @@ -161427,8 +260782,8 @@ def: "The quality of a strand of hair." [AUTO:patterns/patterns/entity_attribute synonym: "quality of strand of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001037 ! strand of hair -relationship: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair +relationship: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:1000254 @@ -161437,8 +260792,8 @@ def: "The quality of a metatarsal bone of digit 5." [AUTO:patterns/patterns/enti synonym: "quality of metatarsal bone of digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003654 ! metatarsal bone of digit 5 -relationship: inheres_in UBERON:0003654 ! metatarsal bone of digit 5 +intersection_of: RO:0000052 UBERON:0003654 ! inheres in metatarsal bone of digit 5 +relationship: RO:0000052 UBERON:0003654 ! inheres in metatarsal bone of digit 5 [Term] id: OBA:1000255 @@ -161447,8 +260802,8 @@ def: "The quality of a dura mater." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of dura mater" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000435 ! meninx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002363 ! dura mater -relationship: inheres_in UBERON:0002363 ! dura mater +intersection_of: RO:0000052 UBERON:0002363 ! inheres in dura mater +relationship: RO:0000052 UBERON:0002363 ! inheres in dura mater [Term] id: OBA:1000256 @@ -161457,8 +260812,8 @@ def: "The quality of a glutamine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of glutamine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000194 ! glutamine family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006541 ! glutamine metabolic process -relationship: inheres_in GO:0006541 ! glutamine metabolic process +intersection_of: RO:0000052 GO:0006541 ! inheres in glutamine metabolic process +relationship: RO:0000052 GO:0006541 ! inheres in glutamine metabolic process [Term] id: OBA:1000257 @@ -161467,8 +260822,8 @@ def: "The quality of a purine nucleobase metabolic process." [AUTO:patterns/patt synonym: "quality of purine nucleobase metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006144 ! purine nucleobase metabolic process -relationship: inheres_in GO:0006144 ! purine nucleobase metabolic process +intersection_of: RO:0000052 GO:0006144 ! inheres in purine nucleobase metabolic process +relationship: RO:0000052 GO:0006144 ! inheres in purine nucleobase metabolic process [Term] id: OBA:1000258 @@ -161477,8 +260832,8 @@ def: "The quality of a blood circulation." [AUTO:patterns/patterns/entity_attrib synonym: "quality of blood circulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008015 ! blood circulation -relationship: inheres_in GO:0008015 ! blood circulation +intersection_of: RO:0000052 GO:0008015 ! inheres in blood circulation +relationship: RO:0000052 GO:0008015 ! inheres in blood circulation [Term] id: OBA:1000259 @@ -161487,8 +260842,8 @@ def: "The quality of a valine metabolic process." [AUTO:patterns/patterns/entity synonym: "quality of valine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000478 ! branched-chain amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006573 ! valine metabolic process -relationship: inheres_in GO:0006573 ! valine metabolic process +intersection_of: RO:0000052 GO:0006573 ! inheres in valine metabolic process +relationship: RO:0000052 GO:0006573 ! inheres in valine metabolic process [Term] id: OBA:1000260 @@ -161497,8 +260852,8 @@ def: "The quality of a odontoid tissue." [AUTO:patterns/patterns/entity_attribut synonym: "quality of odontoid tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010365 ! odontoid tissue -relationship: inheres_in UBERON:0010365 ! odontoid tissue +intersection_of: RO:0000052 UBERON:0010365 ! inheres in odontoid tissue +relationship: RO:0000052 UBERON:0010365 ! inheres in odontoid tissue [Term] id: OBA:1000261 @@ -161507,8 +260862,8 @@ def: "The quality of a tongue muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tongue muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000378 ! tongue muscle -relationship: inheres_in UBERON:0000378 ! tongue muscle +intersection_of: RO:0000052 UBERON:0000378 ! inheres in tongue muscle +relationship: RO:0000052 UBERON:0000378 ! inheres in tongue muscle [Term] id: OBA:1000262 @@ -161517,8 +260872,8 @@ def: "The quality of a greater palatine artery." [AUTO:patterns/patterns/entity_ synonym: "quality of greater palatine artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006664 ! greater palatine artery -relationship: inheres_in UBERON:0006664 ! greater palatine artery +intersection_of: RO:0000052 UBERON:0006664 ! inheres in greater palatine artery +relationship: RO:0000052 UBERON:0006664 ! inheres in greater palatine artery [Term] id: OBA:1000263 @@ -161527,8 +260882,8 @@ def: "The quality of a amniotic fluid." [AUTO:patterns/patterns/entity_attribute synonym: "quality of amniotic fluid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000173 ! amniotic fluid -relationship: inheres_in UBERON:0000173 ! amniotic fluid +intersection_of: RO:0000052 UBERON:0000173 ! inheres in amniotic fluid +relationship: RO:0000052 UBERON:0000173 ! inheres in amniotic fluid [Term] id: OBA:1000264 @@ -161537,8 +260892,8 @@ def: "The quality of a protein glycosylation." [AUTO:patterns/patterns/entity_at synonym: "quality of protein glycosylation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000294 ! glycosylation quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006486 ! protein glycosylation -relationship: inheres_in GO:0006486 ! protein glycosylation +intersection_of: RO:0000052 GO:0006486 ! inheres in protein glycosylation +relationship: RO:0000052 GO:0006486 ! inheres in protein glycosylation [Term] id: OBA:1000265 @@ -161547,8 +260902,8 @@ def: "The quality of a auditory ossicle bone." [AUTO:patterns/patterns/entity_at synonym: "quality of auditory ossicle bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001686 ! auditory ossicle bone -relationship: inheres_in UBERON:0001686 ! auditory ossicle bone +intersection_of: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone +relationship: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone [Term] id: OBA:1000266 @@ -161557,8 +260912,8 @@ def: "The quality of a corneal epithelium." [AUTO:patterns/patterns/entity_attri synonym: "quality of corneal epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001772 ! corneal epithelium -relationship: inheres_in UBERON:0001772 ! corneal epithelium +intersection_of: RO:0000052 UBERON:0001772 ! inheres in corneal epithelium +relationship: RO:0000052 UBERON:0001772 ! inheres in corneal epithelium [Term] id: OBA:1000267 @@ -161567,8 +260922,8 @@ def: "The quality of a meninx of spinal cord." [AUTO:patterns/patterns/entity_at synonym: "quality of meninx of spinal cord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000435 ! meninx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003292 ! meninx of spinal cord -relationship: inheres_in UBERON:0003292 ! meninx of spinal cord +intersection_of: RO:0000052 UBERON:0003292 ! inheres in meninx of spinal cord +relationship: RO:0000052 UBERON:0003292 ! inheres in meninx of spinal cord [Term] id: OBA:1000268 @@ -161577,8 +260932,8 @@ def: "The quality of a cell cycle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of cell cycle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007049 ! cell cycle -relationship: inheres_in GO:0007049 ! cell cycle +intersection_of: RO:0000052 GO:0007049 ! inheres in cell cycle +relationship: RO:0000052 GO:0007049 ! inheres in cell cycle [Term] id: OBA:1000269 @@ -161587,8 +260942,8 @@ def: "The quality of a pedal digit 4." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pedal digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003634 ! pedal digit 4 -relationship: inheres_in UBERON:0003634 ! pedal digit 4 +intersection_of: RO:0000052 UBERON:0003634 ! inheres in pedal digit 4 +relationship: RO:0000052 UBERON:0003634 ! inheres in pedal digit 4 [Term] id: OBA:1000270 @@ -161597,8 +260952,8 @@ def: "The quality of a ganglioside metabolic process." [AUTO:patterns/patterns/e synonym: "quality of ganglioside metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000466 ! glycosphingolipid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001573 ! ganglioside metabolic process -relationship: inheres_in GO:0001573 ! ganglioside metabolic process +intersection_of: RO:0000052 GO:0001573 ! inheres in ganglioside metabolic process +relationship: RO:0000052 GO:0001573 ! inheres in ganglioside metabolic process [Term] id: OBA:1000271 @@ -161607,8 +260962,8 @@ def: "The quality of a distal phalanx of manual digit 5." [AUTO:patterns/pattern synonym: "quality of distal phalanx of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000190 ! distal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 -relationship: inheres_in UBERON:0004314 ! distal phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 +relationship: RO:0000052 UBERON:0004314 ! inheres in distal phalanx of manual digit 5 [Term] id: OBA:1000272 @@ -161617,8 +260972,8 @@ def: "The quality of a deltopectoral crest." [AUTO:patterns/patterns/entity_attr synonym: "quality of deltopectoral crest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002498 ! deltopectoral crest -relationship: inheres_in UBERON:0002498 ! deltopectoral crest +intersection_of: RO:0000052 UBERON:0002498 ! inheres in deltopectoral crest +relationship: RO:0000052 UBERON:0002498 ! inheres in deltopectoral crest [Term] id: OBA:1000273 @@ -161627,8 +260982,8 @@ def: "The quality of a posterior cranial fossa." [AUTO:patterns/patterns/entity_ synonym: "quality of posterior cranial fossa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008788 ! posterior cranial fossa -relationship: inheres_in UBERON:0008788 ! posterior cranial fossa +intersection_of: RO:0000052 UBERON:0008788 ! inheres in posterior cranial fossa +relationship: RO:0000052 UBERON:0008788 ! inheres in posterior cranial fossa [Term] id: OBA:1000274 @@ -161637,8 +260992,8 @@ def: "The quality of a clivus of occipital bone." [AUTO:patterns/patterns/entity synonym: "quality of clivus of occipital bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004108 ! clivus of occipital bone -relationship: inheres_in UBERON:0004108 ! clivus of occipital bone +intersection_of: RO:0000052 UBERON:0004108 ! inheres in clivus of occipital bone +relationship: RO:0000052 UBERON:0004108 ! inheres in clivus of occipital bone [Term] id: OBA:1000275 @@ -161647,8 +261002,8 @@ def: "The quality of a lower urinary tract." [AUTO:patterns/patterns/entity_attr synonym: "quality of lower urinary tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001556 ! lower urinary tract -relationship: inheres_in UBERON:0001556 ! lower urinary tract +intersection_of: RO:0000052 UBERON:0001556 ! inheres in lower urinary tract +relationship: RO:0000052 UBERON:0001556 ! inheres in lower urinary tract [Term] id: OBA:1000276 @@ -161657,8 +261012,8 @@ def: "The quality of a intrinsic muscle of tongue." [AUTO:patterns/patterns/enti synonym: "quality of intrinsic muscle of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000261 ! tongue muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001576 ! intrinsic muscle of tongue -relationship: inheres_in UBERON:0001576 ! intrinsic muscle of tongue +intersection_of: RO:0000052 UBERON:0001576 ! inheres in intrinsic muscle of tongue +relationship: RO:0000052 UBERON:0001576 ! inheres in intrinsic muscle of tongue [Term] id: OBA:1000277 @@ -161667,8 +261022,8 @@ def: "The quality of a nasal cavity." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of nasal cavity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001707 ! nasal cavity -relationship: inheres_in UBERON:0001707 ! nasal cavity +intersection_of: RO:0000052 UBERON:0001707 ! inheres in nasal cavity +relationship: RO:0000052 UBERON:0001707 ! inheres in nasal cavity [Term] id: OBA:1000278 @@ -161677,8 +261032,8 @@ def: "The quality of a social inhibition." [AUTO:patterns/patterns/entity_attrib synonym: "quality of social inhibition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000604 ! social inhibition -relationship: inheres_in NBO:0000604 ! social inhibition +intersection_of: RO:0000052 NBO:0000604 ! inheres in social inhibition +relationship: RO:0000052 NBO:0000604 ! inheres in social inhibition [Term] id: OBA:1000279 @@ -161687,8 +261042,8 @@ def: "The quality of a styloid process of ulna." [AUTO:patterns/patterns/entity_ synonym: "quality of styloid process of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011575 ! styloid process of ulna -relationship: inheres_in UBERON:0011575 ! styloid process of ulna +intersection_of: RO:0000052 UBERON:0011575 ! inheres in styloid process of ulna +relationship: RO:0000052 UBERON:0011575 ! inheres in styloid process of ulna [Term] id: OBA:1000280 @@ -161697,8 +261052,8 @@ def: "The quality of a heart right ventricle." [AUTO:patterns/patterns/entity_at synonym: "quality of heart right ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle -relationship: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle +relationship: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:1000281 @@ -161707,8 +261062,8 @@ def: "The quality of a ocular fundus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ocular fundus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003951 ! ocular fundus -relationship: inheres_in UBERON:0003951 ! ocular fundus +intersection_of: RO:0000052 UBERON:0003951 ! inheres in ocular fundus +relationship: RO:0000052 UBERON:0003951 ! inheres in ocular fundus [Term] id: OBA:1000282 @@ -161717,8 +261072,8 @@ def: "The quality of a upper urinary tract." [AUTO:patterns/patterns/entity_attr synonym: "quality of upper urinary tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011143 ! upper urinary tract -relationship: inheres_in UBERON:0011143 ! upper urinary tract +intersection_of: RO:0000052 UBERON:0011143 ! inheres in upper urinary tract +relationship: RO:0000052 UBERON:0011143 ! inheres in upper urinary tract [Term] id: OBA:1000283 @@ -161728,8 +261083,8 @@ synonym: "quality of distal phalanx of pedal digit 5" EXACT [AUTO:patterns/patte is_a: OBA:1000329 ! pedal digit 5 phalanx quality is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004319 ! distal phalanx of pedal digit 5 -relationship: inheres_in UBERON:0004319 ! distal phalanx of pedal digit 5 +intersection_of: RO:0000052 UBERON:0004319 ! inheres in distal phalanx of pedal digit 5 +relationship: RO:0000052 UBERON:0004319 ! inheres in distal phalanx of pedal digit 5 [Term] id: OBA:1000284 @@ -161738,8 +261093,8 @@ def: "The quality of a phagocyte (sensu Vertebrata)." [AUTO:patterns/patterns/en synonym: "quality of phagocyte (sensu Vertebrata)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000518 ! phagocyte (sensu Vertebrata) -relationship: inheres_in CL:0000518 ! phagocyte (sensu Vertebrata) +intersection_of: RO:0000052 CL:0000518 ! inheres in phagocyte (sensu Vertebrata) +relationship: RO:0000052 CL:0000518 ! inheres in phagocyte (sensu Vertebrata) [Term] id: OBA:1000285 @@ -161748,8 +261103,8 @@ def: "The quality of a brain ventricle." [AUTO:patterns/patterns/entity_attribut synonym: "quality of brain ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004086 ! brain ventricle -relationship: inheres_in UBERON:0004086 ! brain ventricle +intersection_of: RO:0000052 UBERON:0004086 ! inheres in brain ventricle +relationship: RO:0000052 UBERON:0004086 ! inheres in brain ventricle [Term] id: OBA:1000286 @@ -161758,8 +261113,8 @@ def: "The quality of a extrinsic muscle of tongue." [AUTO:patterns/patterns/enti synonym: "quality of extrinsic muscle of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000261 ! tongue muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001575 ! extrinsic muscle of tongue -relationship: inheres_in UBERON:0001575 ! extrinsic muscle of tongue +intersection_of: RO:0000052 UBERON:0001575 ! inheres in extrinsic muscle of tongue +relationship: RO:0000052 UBERON:0001575 ! inheres in extrinsic muscle of tongue [Term] id: OBA:1000287 @@ -161768,8 +261123,8 @@ def: "The quality of a external carotid artery." [AUTO:patterns/patterns/entity_ synonym: "quality of external carotid artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001070 ! external carotid artery -relationship: inheres_in UBERON:0001070 ! external carotid artery +intersection_of: RO:0000052 UBERON:0001070 ! inheres in external carotid artery +relationship: RO:0000052 UBERON:0001070 ! inheres in external carotid artery [Term] id: OBA:1000288 @@ -161778,8 +261133,8 @@ def: "The quality of a lacrimal sac." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of lacrimal sac" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001351 ! lacrimal sac -relationship: inheres_in UBERON:0001351 ! lacrimal sac +intersection_of: RO:0000052 UBERON:0001351 ! inheres in lacrimal sac +relationship: RO:0000052 UBERON:0001351 ! inheres in lacrimal sac [Term] id: OBA:1000289 @@ -161788,8 +261143,8 @@ def: "The quality of a medullary cavity of long bone." [AUTO:patterns/patterns/e synonym: "quality of medullary cavity of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0016413 ! medullary cavity of long bone -relationship: inheres_in UBERON:0016413 ! medullary cavity of long bone +intersection_of: RO:0000052 UBERON:0016413 ! inheres in medullary cavity of long bone +relationship: RO:0000052 UBERON:0016413 ! inheres in medullary cavity of long bone [Term] id: OBA:1000290 @@ -161798,8 +261153,8 @@ def: "The quality of a fallopian tube." [AUTO:patterns/patterns/entity_attribute synonym: "quality of fallopian tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003889 ! fallopian tube -relationship: inheres_in UBERON:0003889 ! fallopian tube +intersection_of: RO:0000052 UBERON:0003889 ! inheres in fallopian tube +relationship: RO:0000052 UBERON:0003889 ! inheres in fallopian tube [Term] id: OBA:1000291 @@ -161809,8 +261164,8 @@ synonym: "quality of distal phalanx of manual digit 4" EXACT [AUTO:patterns/patt is_a: OBA:1000158 ! manual digit 4 phalanx quality is_a: OBA:1000190 ! distal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 -relationship: inheres_in UBERON:0004313 ! distal phalanx of manual digit 4 +intersection_of: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 +relationship: RO:0000052 UBERON:0004313 ! inheres in distal phalanx of manual digit 4 [Term] id: OBA:1000292 @@ -161819,8 +261174,8 @@ def: "The quality of a vein." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001638 ! vein -relationship: inheres_in UBERON:0001638 ! vein +intersection_of: RO:0000052 UBERON:0001638 ! inheres in vein +relationship: RO:0000052 UBERON:0001638 ! inheres in vein [Term] id: OBA:1000293 @@ -161829,8 +261184,8 @@ def: "The quality of a mandibular ramus." [AUTO:patterns/patterns/entity_attribu synonym: "quality of mandibular ramus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000401 ! mandibular ramus -relationship: inheres_in UBERON:0000401 ! mandibular ramus +intersection_of: RO:0000052 UBERON:0000401 ! inheres in mandibular ramus +relationship: RO:0000052 UBERON:0000401 ! inheres in mandibular ramus [Term] id: OBA:1000294 @@ -161839,8 +261194,8 @@ def: "The quality of a glycosylation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of glycosylation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070085 ! glycosylation -relationship: inheres_in GO:0070085 ! glycosylation +intersection_of: RO:0000052 GO:0070085 ! inheres in glycosylation +relationship: RO:0000052 GO:0070085 ! inheres in glycosylation [Term] id: OBA:1000295 @@ -161849,8 +261204,8 @@ def: "The quality of a vestibulocochlear nerve." [AUTO:patterns/patterns/entity_ synonym: "quality of vestibulocochlear nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001648 ! vestibulocochlear nerve -relationship: inheres_in UBERON:0001648 ! vestibulocochlear nerve +intersection_of: RO:0000052 UBERON:0001648 ! inheres in vestibulocochlear nerve +relationship: RO:0000052 UBERON:0001648 ! inheres in vestibulocochlear nerve [Term] id: OBA:1000296 @@ -161859,8 +261214,8 @@ def: "The quality of a distal epiphysis of ulna." [AUTO:patterns/patterns/entity synonym: "quality of distal epiphysis of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004408 ! distal epiphysis of ulna -relationship: inheres_in UBERON:0004408 ! distal epiphysis of ulna +intersection_of: RO:0000052 UBERON:0004408 ! inheres in distal epiphysis of ulna +relationship: RO:0000052 UBERON:0004408 ! inheres in distal epiphysis of ulna [Term] id: OBA:1000297 @@ -161869,8 +261224,8 @@ def: "The quality of a pedal digit 5." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pedal digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003635 ! pedal digit 5 -relationship: inheres_in UBERON:0003635 ! pedal digit 5 +intersection_of: RO:0000052 UBERON:0003635 ! inheres in pedal digit 5 +relationship: RO:0000052 UBERON:0003635 ! inheres in pedal digit 5 [Term] id: OBA:1000298 @@ -161879,8 +261234,8 @@ def: "The quality of a thoracic region of vertebral column." [AUTO:patterns/patt synonym: "quality of thoracic region of vertebral column" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006073 ! thoracic region of vertebral column -relationship: inheres_in UBERON:0006073 ! thoracic region of vertebral column +intersection_of: RO:0000052 UBERON:0006073 ! inheres in thoracic region of vertebral column +relationship: RO:0000052 UBERON:0006073 ! inheres in thoracic region of vertebral column [Term] id: OBA:1000299 @@ -161890,8 +261245,8 @@ synonym: "quality of middle phalanx of pedal digit 4" EXACT [AUTO:patterns/patte is_a: OBA:1000492 ! middle phalanx of pes quality is_a: OBA:1000575 ! pedal digit 4 phalanx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004326 ! middle phalanx of pedal digit 4 -relationship: inheres_in UBERON:0004326 ! middle phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004326 ! inheres in middle phalanx of pedal digit 4 +relationship: RO:0000052 UBERON:0004326 ! inheres in middle phalanx of pedal digit 4 [Term] id: OBA:1000300 @@ -161900,8 +261255,8 @@ def: "The quality of a ulna." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001424 ! ulna -relationship: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna +relationship: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:1000301 @@ -161910,8 +261265,8 @@ def: "The quality of a head blood vessel." [AUTO:patterns/patterns/entity_attrib synonym: "quality of head blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003496 ! head blood vessel -relationship: inheres_in UBERON:0003496 ! head blood vessel +intersection_of: RO:0000052 UBERON:0003496 ! inheres in head blood vessel +relationship: RO:0000052 UBERON:0003496 ! inheres in head blood vessel [Term] id: OBA:1000302 @@ -161920,8 +261275,8 @@ def: "The quality of a sarcosine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of sarcosine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1901052 ! sarcosine metabolic process -relationship: inheres_in GO:1901052 ! sarcosine metabolic process +intersection_of: RO:0000052 GO:1901052 ! inheres in sarcosine metabolic process +relationship: RO:0000052 GO:1901052 ! inheres in sarcosine metabolic process [Term] id: OBA:1000303 @@ -161930,8 +261285,8 @@ def: "The quality of a adenohypophysis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of adenohypophysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002196 ! adenohypophysis -relationship: inheres_in UBERON:0002196 ! adenohypophysis +intersection_of: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis +relationship: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis [Term] id: OBA:1000304 @@ -161940,8 +261295,8 @@ def: "The quality of a proximal epiphysis of radius." [AUTO:patterns/patterns/en synonym: "quality of proximal epiphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004413 ! proximal epiphysis of radius -relationship: inheres_in UBERON:0004413 ! proximal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004413 ! inheres in proximal epiphysis of radius +relationship: RO:0000052 UBERON:0004413 ! inheres in proximal epiphysis of radius [Term] id: OBA:1000305 @@ -161950,8 +261305,8 @@ def: "The quality of a xanthine metabolic process." [AUTO:patterns/patterns/enti synonym: "quality of xanthine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000257 ! purine nucleobase metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0046110 ! xanthine metabolic process -relationship: inheres_in GO:0046110 ! xanthine metabolic process +intersection_of: RO:0000052 GO:0046110 ! inheres in xanthine metabolic process +relationship: RO:0000052 GO:0046110 ! inheres in xanthine metabolic process [Term] id: OBA:1000306 @@ -161960,8 +261315,8 @@ def: "The quality of a great auricular nerve." [AUTO:patterns/patterns/entity_at synonym: "quality of great auricular nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008833 ! great auricular nerve -relationship: inheres_in UBERON:0008833 ! great auricular nerve +intersection_of: RO:0000052 UBERON:0008833 ! inheres in great auricular nerve +relationship: RO:0000052 UBERON:0008833 ! inheres in great auricular nerve [Term] id: OBA:1000307 @@ -161970,8 +261325,8 @@ def: "The quality of a pharyngeal tonsil." [AUTO:patterns/patterns/entity_attrib synonym: "quality of pharyngeal tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000244 ! tonsil quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001732 ! pharyngeal tonsil -relationship: inheres_in UBERON:0001732 ! pharyngeal tonsil +intersection_of: RO:0000052 UBERON:0001732 ! inheres in pharyngeal tonsil +relationship: RO:0000052 UBERON:0001732 ! inheres in pharyngeal tonsil [Term] id: OBA:1000308 @@ -161980,8 +261335,8 @@ def: "The quality of a mediastinum." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of mediastinum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003728 ! mediastinum -relationship: inheres_in UBERON:0003728 ! mediastinum +intersection_of: RO:0000052 UBERON:0003728 ! inheres in mediastinum +relationship: RO:0000052 UBERON:0003728 ! inheres in mediastinum [Term] id: OBA:1000309 @@ -161990,8 +261345,8 @@ def: "The quality of a vestibulo-ocular reflex." [AUTO:patterns/patterns/entity_ synonym: "quality of vestibulo-ocular reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000416 ! vestibulo-ocular reflex -relationship: inheres_in NBO:0000416 ! vestibulo-ocular reflex +intersection_of: RO:0000052 NBO:0000416 ! inheres in vestibulo-ocular reflex +relationship: RO:0000052 NBO:0000416 ! inheres in vestibulo-ocular reflex [Term] id: OBA:1000310 @@ -162000,8 +261355,8 @@ def: "The quality of a clitoris." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002411 ! clitoris -relationship: inheres_in UBERON:0002411 ! clitoris +intersection_of: RO:0000052 UBERON:0002411 ! inheres in clitoris +relationship: RO:0000052 UBERON:0002411 ! inheres in clitoris [Term] id: OBA:1000311 @@ -162010,8 +261365,8 @@ def: "The quality of a chromosome condensation." [AUTO:patterns/patterns/entity_ synonym: "quality of chromosome condensation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030261 ! chromosome condensation -relationship: inheres_in GO:0030261 ! chromosome condensation +intersection_of: RO:0000052 GO:0030261 ! inheres in chromosome condensation +relationship: RO:0000052 GO:0030261 ! inheres in chromosome condensation [Term] id: OBA:1000312 @@ -162020,8 +261375,8 @@ def: "The quality of a vitamin D metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of vitamin D metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042359 ! vitamin D metabolic process -relationship: inheres_in GO:0042359 ! vitamin D metabolic process +intersection_of: RO:0000052 GO:0042359 ! inheres in vitamin D metabolic process +relationship: RO:0000052 GO:0042359 ! inheres in vitamin D metabolic process [Term] id: OBA:1000313 @@ -162030,8 +261385,8 @@ def: "The quality of a procerus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of procerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008588 ! procerus -relationship: inheres_in UBERON:0008588 ! procerus +intersection_of: RO:0000052 UBERON:0008588 ! inheres in procerus +relationship: RO:0000052 UBERON:0008588 ! inheres in procerus [Term] id: OBA:1000314 @@ -162040,8 +261395,8 @@ def: "The quality of a pedal digit." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pedal digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000577 ! digit quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001466 ! pedal digit -relationship: inheres_in UBERON:0001466 ! pedal digit +intersection_of: RO:0000052 UBERON:0001466 ! inheres in pedal digit +relationship: RO:0000052 UBERON:0001466 ! inheres in pedal digit [Term] id: OBA:1000315 @@ -162050,8 +261405,8 @@ def: "The quality of a arginine metabolic process." [AUTO:patterns/patterns/enti synonym: "quality of arginine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000194 ! glutamine family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006525 ! arginine metabolic process -relationship: inheres_in GO:0006525 ! arginine metabolic process +intersection_of: RO:0000052 GO:0006525 ! inheres in arginine metabolic process +relationship: RO:0000052 GO:0006525 ! inheres in arginine metabolic process [Term] id: OBA:1000316 @@ -162060,8 +261415,8 @@ def: "The quality of a jugal bone." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of jugal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000064 ! dermal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001683 ! jugal bone -relationship: inheres_in UBERON:0001683 ! jugal bone +intersection_of: RO:0000052 UBERON:0001683 ! inheres in jugal bone +relationship: RO:0000052 UBERON:0001683 ! inheres in jugal bone [Term] id: OBA:1000317 @@ -162070,8 +261425,8 @@ def: "The quality of a leucine metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of leucine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000478 ! branched-chain amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006551 ! leucine metabolic process -relationship: inheres_in GO:0006551 ! leucine metabolic process +intersection_of: RO:0000052 GO:0006551 ! inheres in leucine metabolic process +relationship: RO:0000052 GO:0006551 ! inheres in leucine metabolic process [Term] id: OBA:1000318 @@ -162080,8 +261435,8 @@ def: "The quality of a lumbosacral nerve plexus." [AUTO:patterns/patterns/entity synonym: "quality of lumbosacral nerve plexus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000638 ! spinal nerve plexus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001815 ! lumbosacral nerve plexus -relationship: inheres_in UBERON:0001815 ! lumbosacral nerve plexus +intersection_of: RO:0000052 UBERON:0001815 ! inheres in lumbosacral nerve plexus +relationship: RO:0000052 UBERON:0001815 ! inheres in lumbosacral nerve plexus [Term] id: OBA:1000319 @@ -162090,8 +261445,8 @@ def: "The quality of a glossopharyngeal nerve." [AUTO:patterns/patterns/entity_a synonym: "quality of glossopharyngeal nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001649 ! glossopharyngeal nerve -relationship: inheres_in UBERON:0001649 ! glossopharyngeal nerve +intersection_of: RO:0000052 UBERON:0001649 ! inheres in glossopharyngeal nerve +relationship: RO:0000052 UBERON:0001649 ! inheres in glossopharyngeal nerve [Term] id: OBA:1000320 @@ -162100,8 +261455,8 @@ def: "The quality of a pulmonary part of lymphatic system." [AUTO:patterns/patte synonym: "quality of pulmonary part of lymphatic system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0018226 ! pulmonary part of lymphatic system -relationship: inheres_in UBERON:0018226 ! pulmonary part of lymphatic system +intersection_of: RO:0000052 UBERON:0018226 ! inheres in pulmonary part of lymphatic system +relationship: RO:0000052 UBERON:0018226 ! inheres in pulmonary part of lymphatic system [Term] id: OBA:1000321 @@ -162110,8 +261465,8 @@ def: "The quality of a trigeminal nerve." [AUTO:patterns/patterns/entity_attribu synonym: "quality of trigeminal nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001645 ! trigeminal nerve -relationship: inheres_in UBERON:0001645 ! trigeminal nerve +intersection_of: RO:0000052 UBERON:0001645 ! inheres in trigeminal nerve +relationship: RO:0000052 UBERON:0001645 ! inheres in trigeminal nerve [Term] id: OBA:1000322 @@ -162120,8 +261475,8 @@ def: "The quality of a masticatory muscle." [AUTO:patterns/patterns/entity_attri synonym: "quality of masticatory muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000425 ! jaw muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003681 ! masticatory muscle -relationship: inheres_in UBERON:0003681 ! masticatory muscle +intersection_of: RO:0000052 UBERON:0003681 ! inheres in masticatory muscle +relationship: RO:0000052 UBERON:0003681 ! inheres in masticatory muscle [Term] id: OBA:1000323 @@ -162130,8 +261485,8 @@ def: "The quality of a divalent inorganic cation homeostasis." [AUTO:patterns/pa synonym: "quality of divalent inorganic cation homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000630 ! cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072507 ! divalent inorganic cation homeostasis -relationship: inheres_in GO:0072507 ! divalent inorganic cation homeostasis +intersection_of: RO:0000052 GO:0072507 ! inheres in divalent inorganic cation homeostasis +relationship: RO:0000052 GO:0072507 ! inheres in divalent inorganic cation homeostasis [Term] id: OBA:1000324 @@ -162140,8 +261495,8 @@ def: "The quality of a central nervous system myelination." [AUTO:patterns/patte synonym: "quality of central nervous system myelination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000920 ! myelination trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0022010 ! central nervous system myelination -relationship: inheres_in GO:0022010 ! central nervous system myelination +intersection_of: RO:0000052 GO:0022010 ! inheres in central nervous system myelination +relationship: RO:0000052 GO:0022010 ! inheres in central nervous system myelination [Term] id: OBA:1000325 @@ -162150,8 +261505,8 @@ def: "The quality of a distal phalanx of manual digit 2." [AUTO:patterns/pattern synonym: "quality of distal phalanx of manual digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000190 ! distal phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 -relationship: inheres_in UBERON:0004311 ! distal phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 +relationship: RO:0000052 UBERON:0004311 ! inheres in distal phalanx of manual digit 2 [Term] id: OBA:1000326 @@ -162160,8 +261515,8 @@ def: "The quality of a humerus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000976 ! humerus -relationship: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus +relationship: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:1000327 @@ -162170,8 +261525,8 @@ def: "The quality of a renal pelvis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of renal pelvis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001224 ! renal pelvis -relationship: inheres_in UBERON:0001224 ! renal pelvis +intersection_of: RO:0000052 UBERON:0001224 ! inheres in renal pelvis +relationship: RO:0000052 UBERON:0001224 ! inheres in renal pelvis [Term] id: OBA:1000328 @@ -162181,8 +261536,8 @@ synonym: "quality of distal phalanx of pedal digit 3" EXACT [AUTO:patterns/patte is_a: OBA:1000378 ! pedal digit 3 phalanx quality is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004317 ! distal phalanx of pedal digit 3 -relationship: inheres_in UBERON:0004317 ! distal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004317 ! inheres in distal phalanx of pedal digit 3 +relationship: RO:0000052 UBERON:0004317 ! inheres in distal phalanx of pedal digit 3 [Term] id: OBA:1000329 @@ -162191,8 +261546,8 @@ def: "The quality of a pedal digit 5 phalanx." [AUTO:patterns/patterns/entity_at synonym: "quality of pedal digit 5 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003863 ! pedal digit 5 phalanx -relationship: inheres_in UBERON:0003863 ! pedal digit 5 phalanx +intersection_of: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx +relationship: RO:0000052 UBERON:0003863 ! inheres in pedal digit 5 phalanx [Term] id: OBA:1000330 @@ -162201,8 +261556,8 @@ def: "The quality of a adrenal cortex." [AUTO:patterns/patterns/entity_attribute synonym: "quality of adrenal cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001235 ! adrenal cortex -relationship: inheres_in UBERON:0001235 ! adrenal cortex +intersection_of: RO:0000052 UBERON:0001235 ! inheres in adrenal cortex +relationship: RO:0000052 UBERON:0001235 ! inheres in adrenal cortex [Term] id: OBA:1000331 @@ -162211,8 +261566,8 @@ def: "The quality of a epiphysis of fibula." [AUTO:patterns/patterns/entity_attr synonym: "quality of epiphysis of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004388 ! epiphysis of fibula -relationship: inheres_in UBERON:0004388 ! epiphysis of fibula +intersection_of: RO:0000052 UBERON:0004388 ! inheres in epiphysis of fibula +relationship: RO:0000052 UBERON:0004388 ! inheres in epiphysis of fibula [Term] id: OBA:1000332 @@ -162221,8 +261576,8 @@ def: "The quality of a kidney pyramid." [AUTO:patterns/patterns/entity_attribute synonym: "quality of kidney pyramid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004200 ! kidney pyramid -relationship: inheres_in UBERON:0004200 ! kidney pyramid +intersection_of: RO:0000052 UBERON:0004200 ! inheres in kidney pyramid +relationship: RO:0000052 UBERON:0004200 ! inheres in kidney pyramid [Term] id: OBA:1000333 @@ -162231,8 +261586,8 @@ def: "The quality of a zygomaticus major muscle." [AUTO:patterns/patterns/entity synonym: "quality of zygomaticus major muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008593 ! zygomaticus major muscle -relationship: inheres_in UBERON:0008593 ! zygomaticus major muscle +intersection_of: RO:0000052 UBERON:0008593 ! inheres in zygomaticus major muscle +relationship: RO:0000052 UBERON:0008593 ! inheres in zygomaticus major muscle [Term] id: OBA:1000334 @@ -162241,8 +261596,8 @@ def: "The quality of a acetabular part of hip bone." [AUTO:patterns/patterns/ent synonym: "quality of acetabular part of hip bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001269 ! acetabular part of hip bone -relationship: inheres_in UBERON:0001269 ! acetabular part of hip bone +intersection_of: RO:0000052 UBERON:0001269 ! inheres in acetabular part of hip bone +relationship: RO:0000052 UBERON:0001269 ! inheres in acetabular part of hip bone [Term] id: OBA:1000335 @@ -162251,8 +261606,8 @@ def: "The quality of a cuspid." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of cuspid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003674 ! cuspid -relationship: inheres_in UBERON:0003674 ! cuspid +intersection_of: RO:0000052 UBERON:0003674 ! inheres in cuspid +relationship: RO:0000052 UBERON:0003674 ! inheres in cuspid [Term] id: OBA:1000336 @@ -162261,8 +261616,8 @@ def: "The quality of a lingual nerve." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of lingual nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003721 ! lingual nerve -relationship: inheres_in UBERON:0003721 ! lingual nerve +intersection_of: RO:0000052 UBERON:0003721 ! inheres in lingual nerve +relationship: RO:0000052 UBERON:0003721 ! inheres in lingual nerve [Term] id: OBA:1000337 @@ -162271,8 +261626,8 @@ def: "The quality of a soft palate." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of soft palate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001733 ! soft palate -relationship: inheres_in UBERON:0001733 ! soft palate +intersection_of: RO:0000052 UBERON:0001733 ! inheres in soft palate +relationship: RO:0000052 UBERON:0001733 ! inheres in soft palate [Term] id: OBA:1000338 @@ -162281,8 +261636,8 @@ def: "The quality of a pyruvate family amino acid metabolic process." [AUTO:patt synonym: "quality of pyruvate family amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009078 ! pyruvate family amino acid metabolic process -relationship: inheres_in GO:0009078 ! pyruvate family amino acid metabolic process +intersection_of: RO:0000052 GO:0009078 ! inheres in pyruvate family amino acid metabolic process +relationship: RO:0000052 GO:0009078 ! inheres in pyruvate family amino acid metabolic process [Term] id: OBA:1000339 @@ -162291,8 +261646,8 @@ def: "The quality of a prepuce of penis." [AUTO:patterns/patterns/entity_attribu synonym: "quality of prepuce of penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001332 ! prepuce of penis -relationship: inheres_in UBERON:0001332 ! prepuce of penis +intersection_of: RO:0000052 UBERON:0001332 ! inheres in prepuce of penis +relationship: RO:0000052 UBERON:0001332 ! inheres in prepuce of penis [Term] id: OBA:1000340 @@ -162301,8 +261656,8 @@ def: "The quality of a tibia." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000979 ! tibia -relationship: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia +relationship: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:1000341 @@ -162311,8 +261666,8 @@ def: "The quality of a hindlimb joint." [AUTO:patterns/patterns/entity_attribute synonym: "quality of hindlimb joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003840 ! hindlimb joint -relationship: inheres_in UBERON:0003840 ! hindlimb joint +intersection_of: RO:0000052 UBERON:0003840 ! inheres in hindlimb joint +relationship: RO:0000052 UBERON:0003840 ! inheres in hindlimb joint [Term] id: OBA:1000342 @@ -162321,8 +261676,8 @@ def: "The quality of a hairline." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hairline" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004104 ! hairline -relationship: inheres_in UBERON:0004104 ! hairline +intersection_of: RO:0000052 UBERON:0004104 ! inheres in hairline +relationship: RO:0000052 UBERON:0004104 ! inheres in hairline [Term] id: OBA:1000343 @@ -162331,8 +261686,8 @@ def: "The quality of a glycolipid metabolic process." [AUTO:patterns/patterns/en synonym: "quality of glycolipid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000151 ! liposaccharide metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006664 ! glycolipid metabolic process -relationship: inheres_in GO:0006664 ! glycolipid metabolic process +intersection_of: RO:0000052 GO:0006664 ! inheres in glycolipid metabolic process +relationship: RO:0000052 GO:0006664 ! inheres in glycolipid metabolic process [Term] id: OBA:1000344 @@ -162341,8 +261696,8 @@ def: "The quality of a labium minora." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of labium minora" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000187 ! genital labium quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004014 ! labium minora -relationship: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora +relationship: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:1000345 @@ -162351,8 +261706,8 @@ def: "The quality of a physiologic nystagmus." [AUTO:patterns/patterns/entity_at synonym: "quality of physiologic nystagmus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000309 ! vestibulo-ocular reflex quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000417 ! physiologic nystagmus -relationship: inheres_in NBO:0000417 ! physiologic nystagmus +intersection_of: RO:0000052 NBO:0000417 ! inheres in physiologic nystagmus +relationship: RO:0000052 NBO:0000417 ! inheres in physiologic nystagmus [Term] id: OBA:1000346 @@ -162361,8 +261716,8 @@ def: "The quality of a hip joint." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hip joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001486 ! hip joint -relationship: inheres_in UBERON:0001486 ! hip joint +intersection_of: RO:0000052 UBERON:0001486 ! inheres in hip joint +relationship: RO:0000052 UBERON:0001486 ! inheres in hip joint [Term] id: OBA:1000347 @@ -162371,8 +261726,8 @@ def: "The quality of a palmar skin crease." [AUTO:patterns/patterns/entity_attri synonym: "quality of palmar skin crease" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015052 ! surface structure trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0019246 ! palmar skin crease -relationship: inheres_in UBERON:0019246 ! palmar skin crease +intersection_of: RO:0000052 UBERON:0019246 ! inheres in palmar skin crease +relationship: RO:0000052 UBERON:0019246 ! inheres in palmar skin crease [Term] id: OBA:1000348 @@ -162381,8 +261736,8 @@ def: "The quality of a aromatic amino acid family metabolic process." [AUTO:patt synonym: "quality of aromatic amino acid family metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009072 ! aromatic amino acid family metabolic process -relationship: inheres_in GO:0009072 ! aromatic amino acid family metabolic process +intersection_of: RO:0000052 GO:0009072 ! inheres in aromatic amino acid family metabolic process +relationship: RO:0000052 GO:0009072 ! inheres in aromatic amino acid family metabolic process [Term] id: OBA:1000349 @@ -162391,18 +261746,18 @@ def: "The quality of a vitamin A metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of vitamin A metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006776 ! vitamin A metabolic process -relationship: inheres_in GO:0006776 ! vitamin A metabolic process +intersection_of: RO:0000052 GO:0006776 ! inheres in vitamin A metabolic process +relationship: RO:0000052 GO:0006776 ! inheres in vitamin A metabolic process [Term] id: OBA:1000350 name: fontanelle quality def: "The quality of a fontanelle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0100003 ! anatomical entity attribute +is_a: OBA:1000211 ! cranial suture quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002221 ! fontanelle -relationship: inheres_in UBERON:0002221 ! fontanelle +intersection_of: RO:0000052 UBERON:0002221 ! inheres in fontanelle +relationship: RO:0000052 UBERON:0002221 ! inheres in fontanelle [Term] id: OBA:1000351 @@ -162411,8 +261766,8 @@ def: "The quality of a levator labii superioris." [AUTO:patterns/patterns/entity synonym: "quality of levator labii superioris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001580 ! levator labii superioris -relationship: inheres_in UBERON:0001580 ! levator labii superioris +intersection_of: RO:0000052 UBERON:0001580 ! inheres in levator labii superioris +relationship: RO:0000052 UBERON:0001580 ! inheres in levator labii superioris [Term] id: OBA:1000352 @@ -162421,8 +261776,8 @@ def: "The quality of a mandible condylar process." [AUTO:patterns/patterns/entit synonym: "quality of mandible condylar process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004657 ! mandible condylar process -relationship: inheres_in UBERON:0004657 ! mandible condylar process +intersection_of: RO:0000052 UBERON:0004657 ! inheres in mandible condylar process +relationship: RO:0000052 UBERON:0004657 ! inheres in mandible condylar process [Term] id: OBA:1000353 @@ -162431,8 +261786,8 @@ def: "The quality of a pedal digit 2 phalanx." [AUTO:patterns/patterns/entity_at synonym: "quality of pedal digit 2 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003641 ! pedal digit 2 phalanx -relationship: inheres_in UBERON:0003641 ! pedal digit 2 phalanx +intersection_of: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx +relationship: RO:0000052 UBERON:0003641 ! inheres in pedal digit 2 phalanx [Term] id: OBA:1000354 @@ -162441,8 +261796,8 @@ def: "The quality of a lysine metabolic process." [AUTO:patterns/patterns/entity synonym: "quality of lysine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000596 ! aspartate family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006553 ! lysine metabolic process -relationship: inheres_in GO:0006553 ! lysine metabolic process +intersection_of: RO:0000052 GO:0006553 ! inheres in lysine metabolic process +relationship: RO:0000052 GO:0006553 ! inheres in lysine metabolic process [Term] id: OBA:1000355 @@ -162451,8 +261806,8 @@ def: "The quality of a lingual tonsil." [AUTO:patterns/patterns/entity_attribute synonym: "quality of lingual tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000244 ! tonsil quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007250 ! lingual tonsil -relationship: inheres_in UBERON:0007250 ! lingual tonsil +intersection_of: RO:0000052 UBERON:0007250 ! inheres in lingual tonsil +relationship: RO:0000052 UBERON:0007250 ! inheres in lingual tonsil [Term] id: OBA:1000356 @@ -162461,8 +261816,8 @@ def: "The quality of a temperature homeostasis." [AUTO:patterns/patterns/entity_ synonym: "quality of temperature homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001764 ! homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001659 ! temperature homeostasis -relationship: inheres_in GO:0001659 ! temperature homeostasis +intersection_of: RO:0000052 GO:0001659 ! inheres in temperature homeostasis +relationship: RO:0000052 GO:0001659 ! inheres in temperature homeostasis [Term] id: OBA:1000357 @@ -162471,8 +261826,8 @@ def: "The quality of a helix of outer ear." [AUTO:patterns/patterns/entity_attri synonym: "quality of helix of outer ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002488 ! helix of outer ear -relationship: inheres_in UBERON:0002488 ! helix of outer ear +intersection_of: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear +relationship: RO:0000052 UBERON:0002488 ! inheres in helix of outer ear [Term] id: OBA:1000358 @@ -162481,8 +261836,8 @@ def: "The quality of a blood coagulation, intrinsic pathway." [AUTO:patterns/pat synonym: "quality of blood coagulation, intrinsic pathway" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007597 ! blood coagulation, intrinsic pathway -relationship: inheres_in GO:0007597 ! blood coagulation, intrinsic pathway +intersection_of: RO:0000052 GO:0007597 ! inheres in blood coagulation, intrinsic pathway +relationship: RO:0000052 GO:0007597 ! inheres in blood coagulation, intrinsic pathway [Term] id: OBA:1000359 @@ -162492,8 +261847,8 @@ synonym: "quality of methionine metabolic process" EXACT [AUTO:patterns/patterns is_a: OBA:1000499 ! sulfur amino acid metabolic process quality is_a: OBA:1000596 ! aspartate family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006555 ! methionine metabolic process -relationship: inheres_in GO:0006555 ! methionine metabolic process +intersection_of: RO:0000052 GO:0006555 ! inheres in methionine metabolic process +relationship: RO:0000052 GO:0006555 ! inheres in methionine metabolic process [Term] id: OBA:1000360 @@ -162502,8 +261857,8 @@ def: "The quality of a hypoglossal nerve." [AUTO:patterns/patterns/entity_attrib synonym: "quality of hypoglossal nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001650 ! hypoglossal nerve -relationship: inheres_in UBERON:0001650 ! hypoglossal nerve +intersection_of: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve +relationship: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve [Term] id: OBA:1000361 @@ -162512,8 +261867,8 @@ def: "The quality of a nasolabial region." [AUTO:patterns/patterns/entity_attrib synonym: "quality of nasolabial region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004101 ! nasolabial region -relationship: inheres_in UBERON:0004101 ! nasolabial region +intersection_of: RO:0000052 UBERON:0004101 ! inheres in nasolabial region +relationship: RO:0000052 UBERON:0004101 ! inheres in nasolabial region [Term] id: OBA:1000362 @@ -162522,8 +261877,8 @@ def: "The quality of a tricarboxylic acid cycle." [AUTO:patterns/patterns/entity synonym: "quality of tricarboxylic acid cycle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006099 ! tricarboxylic acid cycle -relationship: inheres_in GO:0006099 ! tricarboxylic acid cycle +intersection_of: RO:0000052 GO:0006099 ! inheres in tricarboxylic acid cycle +relationship: RO:0000052 GO:0006099 ! inheres in tricarboxylic acid cycle [Term] id: OBA:1000363 @@ -162532,8 +261887,8 @@ def: "The quality of a frontal sinus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of frontal sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000172 ! paranasal sinus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001760 ! frontal sinus -relationship: inheres_in UBERON:0001760 ! frontal sinus +intersection_of: RO:0000052 UBERON:0001760 ! inheres in frontal sinus +relationship: RO:0000052 UBERON:0001760 ! inheres in frontal sinus [Term] id: OBA:1000364 @@ -162542,8 +261897,8 @@ def: "The quality of a third ventricle." [AUTO:patterns/patterns/entity_attribut synonym: "quality of third ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000285 ! brain ventricle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002286 ! third ventricle -relationship: inheres_in UBERON:0002286 ! third ventricle +intersection_of: RO:0000052 UBERON:0002286 ! inheres in third ventricle +relationship: RO:0000052 UBERON:0002286 ! inheres in third ventricle [Term] id: OBA:1000365 @@ -162552,8 +261907,8 @@ def: "The quality of a substantia nigra." [AUTO:patterns/patterns/entity_attribu synonym: "quality of substantia nigra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002038 ! substantia nigra -relationship: inheres_in UBERON:0002038 ! substantia nigra +intersection_of: RO:0000052 UBERON:0002038 ! inheres in substantia nigra +relationship: RO:0000052 UBERON:0002038 ! inheres in substantia nigra [Term] id: OBA:1000366 @@ -162562,8 +261917,8 @@ def: "The quality of a prostaglandin metabolic process." [AUTO:patterns/patterns synonym: "quality of prostaglandin metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000576 ! unsaturated fatty acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006693 ! prostaglandin metabolic process -relationship: inheres_in GO:0006693 ! prostaglandin metabolic process +intersection_of: RO:0000052 GO:0006693 ! inheres in prostaglandin metabolic process +relationship: RO:0000052 GO:0006693 ! inheres in prostaglandin metabolic process [Term] id: OBA:1000367 @@ -162572,8 +261927,8 @@ def: "The quality of a dicarboxylic acid metabolic process." [AUTO:patterns/patt synonym: "quality of dicarboxylic acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000583 ! carboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043648 ! dicarboxylic acid metabolic process -relationship: inheres_in GO:0043648 ! dicarboxylic acid metabolic process +intersection_of: RO:0000052 GO:0043648 ! inheres in dicarboxylic acid metabolic process +relationship: RO:0000052 GO:0043648 ! inheres in dicarboxylic acid metabolic process [Term] id: OBA:1000368 @@ -162582,8 +261937,8 @@ def: "The quality of a micturition." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of micturition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000505 ! renal system process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060073 ! micturition -relationship: inheres_in GO:0060073 ! micturition +intersection_of: RO:0000052 GO:0060073 ! inheres in micturition +relationship: RO:0000052 GO:0060073 ! inheres in micturition [Term] id: OBA:1000369 @@ -162592,8 +261947,8 @@ def: "The quality of a behavior process." [AUTO:patterns/patterns/entity_attribu synonym: "quality of behavior process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000313 ! behavior process -relationship: inheres_in NBO:0000313 ! behavior process +intersection_of: RO:0000052 NBO:0000313 ! inheres in behavior process +relationship: RO:0000052 NBO:0000313 ! inheres in behavior process [Term] id: OBA:1000370 @@ -162602,8 +261957,8 @@ def: "The quality of a infraorbital artery." [AUTO:patterns/patterns/entity_attr synonym: "quality of infraorbital artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004646 ! infraorbital artery -relationship: inheres_in UBERON:0004646 ! infraorbital artery +intersection_of: RO:0000052 UBERON:0004646 ! inheres in infraorbital artery +relationship: RO:0000052 UBERON:0004646 ! inheres in infraorbital artery [Term] id: OBA:1000371 @@ -162612,8 +261967,8 @@ def: "The quality of a mandible coronoid process." [AUTO:patterns/patterns/entit synonym: "quality of mandible coronoid process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004660 ! mandible coronoid process -relationship: inheres_in UBERON:0004660 ! mandible coronoid process +intersection_of: RO:0000052 UBERON:0004660 ! inheres in mandible coronoid process +relationship: RO:0000052 UBERON:0004660 ! inheres in mandible coronoid process [Term] id: OBA:1000372 @@ -162622,8 +261977,8 @@ def: "The quality of a suckling behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of suckling behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000748 ! feeding behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000054 ! suckling behavior -relationship: inheres_in NBO:0000054 ! suckling behavior +intersection_of: RO:0000052 NBO:0000054 ! inheres in suckling behavior +relationship: RO:0000052 NBO:0000054 ! inheres in suckling behavior [Term] id: OBA:1000373 @@ -162632,8 +261987,8 @@ def: "The quality of a neurotransmitter metabolic process." [AUTO:patterns/patte synonym: "quality of neurotransmitter metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042133 ! neurotransmitter metabolic process -relationship: inheres_in GO:0042133 ! neurotransmitter metabolic process +intersection_of: RO:0000052 GO:0042133 ! inheres in neurotransmitter metabolic process +relationship: RO:0000052 GO:0042133 ! inheres in neurotransmitter metabolic process [Term] id: OBA:1000374 @@ -162642,8 +261997,8 @@ def: "The quality of a internal carotid artery." [AUTO:patterns/patterns/entity_ synonym: "quality of internal carotid artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001532 ! internal carotid artery -relationship: inheres_in UBERON:0001532 ! internal carotid artery +intersection_of: RO:0000052 UBERON:0001532 ! inheres in internal carotid artery +relationship: RO:0000052 UBERON:0001532 ! inheres in internal carotid artery [Term] id: OBA:1000375 @@ -162652,8 +262007,8 @@ def: "The quality of a hindlimb zeugopod." [AUTO:patterns/patterns/entity_attrib synonym: "quality of hindlimb zeugopod" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003823 ! hindlimb zeugopod -relationship: inheres_in UBERON:0003823 ! hindlimb zeugopod +intersection_of: RO:0000052 UBERON:0003823 ! inheres in hindlimb zeugopod +relationship: RO:0000052 UBERON:0003823 ! inheres in hindlimb zeugopod [Term] id: OBA:1000376 @@ -162662,8 +262017,8 @@ def: "The quality of a aggressive behavior." [AUTO:patterns/patterns/entity_attr synonym: "quality of aggressive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000015 ! aggressive behavior -relationship: inheres_in NBO:0000015 ! aggressive behavior +intersection_of: RO:0000052 NBO:0000015 ! inheres in aggressive behavior +relationship: RO:0000052 NBO:0000015 ! inheres in aggressive behavior [Term] id: OBA:1000377 @@ -162672,8 +262027,8 @@ def: "The quality of a premaxilla." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of premaxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000064 ! dermal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002244 ! premaxilla -relationship: inheres_in UBERON:0002244 ! premaxilla +intersection_of: RO:0000052 UBERON:0002244 ! inheres in premaxilla +relationship: RO:0000052 UBERON:0002244 ! inheres in premaxilla [Term] id: OBA:1000378 @@ -162682,8 +262037,8 @@ def: "The quality of a pedal digit 3 phalanx." [AUTO:patterns/patterns/entity_at synonym: "quality of pedal digit 3 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003642 ! pedal digit 3 phalanx -relationship: inheres_in UBERON:0003642 ! pedal digit 3 phalanx +intersection_of: RO:0000052 UBERON:0003642 ! inheres in pedal digit 3 phalanx +relationship: RO:0000052 UBERON:0003642 ! inheres in pedal digit 3 phalanx [Term] id: OBA:1000379 @@ -162692,8 +262047,8 @@ def: "The quality of a cartilage of nasal septum." [AUTO:patterns/patterns/entit synonym: "quality of cartilage of nasal septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003407 ! cartilage of nasal septum -relationship: inheres_in UBERON:0003407 ! cartilage of nasal septum +intersection_of: RO:0000052 UBERON:0003407 ! inheres in cartilage of nasal septum +relationship: RO:0000052 UBERON:0003407 ! inheres in cartilage of nasal septum [Term] id: OBA:1000380 @@ -162702,8 +262057,8 @@ def: "The quality of a diaphysis of radius." [AUTO:patterns/patterns/entity_attr synonym: "quality of diaphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000552 ! diaphysis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001028 ! diaphysis of radius -relationship: inheres_in UBERON:0001028 ! diaphysis of radius +intersection_of: RO:0000052 UBERON:0001028 ! inheres in diaphysis of radius +relationship: RO:0000052 UBERON:0001028 ! inheres in diaphysis of radius [Term] id: OBA:1000381 @@ -162712,8 +262067,8 @@ def: "The quality of a astrocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of astrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000236 ! glial cell quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000127 ! astrocyte -relationship: inheres_in CL:0000127 ! astrocyte +intersection_of: RO:0000052 CL:0000127 ! inheres in astrocyte +relationship: RO:0000052 CL:0000127 ! inheres in astrocyte [Term] id: OBA:1000382 @@ -162722,8 +262077,8 @@ def: "The quality of a middle phalanx of manus." [AUTO:patterns/patterns/entity_ synonym: "quality of middle phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000632 ! phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003864 ! middle phalanx of manus -relationship: inheres_in UBERON:0003864 ! middle phalanx of manus +intersection_of: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus +relationship: RO:0000052 UBERON:0003864 ! inheres in middle phalanx of manus [Term] id: OBA:1000383 @@ -162733,8 +262088,8 @@ synonym: "quality of cysteine metabolic process" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000220 ! serine family amino acid metabolic process quality is_a: OBA:1000499 ! sulfur amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006534 ! cysteine metabolic process -relationship: inheres_in GO:0006534 ! cysteine metabolic process +intersection_of: RO:0000052 GO:0006534 ! inheres in cysteine metabolic process +relationship: RO:0000052 GO:0006534 ! inheres in cysteine metabolic process [Term] id: OBA:1000384 @@ -162743,8 +262098,8 @@ def: "The quality of a anxiety-related behavior." [AUTO:patterns/patterns/entity synonym: "quality of anxiety-related behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000225 ! fear/anxiety related behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000092 ! anxiety-related behavior -relationship: inheres_in NBO:0000092 ! anxiety-related behavior +intersection_of: RO:0000052 NBO:0000092 ! inheres in anxiety-related behavior +relationship: RO:0000052 NBO:0000092 ! inheres in anxiety-related behavior [Term] id: OBA:1000385 @@ -162753,8 +262108,8 @@ def: "The quality of a iris." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001769 ! iris -relationship: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris +relationship: RO:0000052 UBERON:0001769 ! inheres in iris [Term] id: OBA:1000386 @@ -162763,8 +262118,8 @@ def: "The quality of a infra-orbital nerve." [AUTO:patterns/patterns/entity_attr synonym: "quality of infra-orbital nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0018408 ! infra-orbital nerve -relationship: inheres_in UBERON:0018408 ! infra-orbital nerve +intersection_of: RO:0000052 UBERON:0018408 ! inheres in infra-orbital nerve +relationship: RO:0000052 UBERON:0018408 ! inheres in infra-orbital nerve [Term] id: OBA:1000387 @@ -162773,8 +262128,8 @@ def: "The quality of a fascia." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fascia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008982 ! fascia -relationship: inheres_in UBERON:0008982 ! fascia +intersection_of: RO:0000052 UBERON:0008982 ! inheres in fascia +relationship: RO:0000052 UBERON:0008982 ! inheres in fascia [Term] id: OBA:1000388 @@ -162783,8 +262138,8 @@ def: "The quality of a levator anguli oris." [AUTO:patterns/patterns/entity_attr synonym: "quality of levator anguli oris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008595 ! levator anguli oris -relationship: inheres_in UBERON:0008595 ! levator anguli oris +intersection_of: RO:0000052 UBERON:0008595 ! inheres in levator anguli oris +relationship: RO:0000052 UBERON:0008595 ! inheres in levator anguli oris [Term] id: OBA:1000389 @@ -162794,8 +262149,8 @@ synonym: "quality of middle phalanx of pedal digit 2" EXACT [AUTO:patterns/patte is_a: OBA:1000353 ! pedal digit 2 phalanx quality is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 -relationship: inheres_in UBERON:0004324 ! middle phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 +relationship: RO:0000052 UBERON:0004324 ! inheres in middle phalanx of pedal digit 2 [Term] id: OBA:1000390 @@ -162804,8 +262159,8 @@ def: "The quality of a anterior segment of eyeball." [AUTO:patterns/patterns/ent synonym: "quality of anterior segment of eyeball" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001801 ! anterior segment of eyeball -relationship: inheres_in UBERON:0001801 ! anterior segment of eyeball +intersection_of: RO:0000052 UBERON:0001801 ! inheres in anterior segment of eyeball +relationship: RO:0000052 UBERON:0001801 ! inheres in anterior segment of eyeball [Term] id: OBA:1000391 @@ -162814,8 +262169,8 @@ def: "The quality of a blood coagulation, extrinsic pathway." [AUTO:patterns/pat synonym: "quality of blood coagulation, extrinsic pathway" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007598 ! blood coagulation, extrinsic pathway -relationship: inheres_in GO:0007598 ! blood coagulation, extrinsic pathway +intersection_of: RO:0000052 GO:0007598 ! inheres in blood coagulation, extrinsic pathway +relationship: RO:0000052 GO:0007598 ! inheres in blood coagulation, extrinsic pathway [Term] id: OBA:1000392 @@ -162824,8 +262179,8 @@ def: "The quality of a long-chain fatty acid metabolic process." [AUTO:patterns/ synonym: "quality of long-chain fatty acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000155 ! fatty acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001676 ! long-chain fatty acid metabolic process -relationship: inheres_in GO:0001676 ! long-chain fatty acid metabolic process +intersection_of: RO:0000052 GO:0001676 ! inheres in long-chain fatty acid metabolic process +relationship: RO:0000052 GO:0001676 ! inheres in long-chain fatty acid metabolic process [Term] id: OBA:1000393 @@ -162834,8 +262189,8 @@ def: "The quality of a lateral rectus extra-ocular muscle." [AUTO:patterns/patte synonym: "quality of lateral rectus extra-ocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001603 ! lateral rectus extra-ocular muscle -relationship: inheres_in UBERON:0001603 ! lateral rectus extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001603 ! inheres in lateral rectus extra-ocular muscle +relationship: RO:0000052 UBERON:0001603 ! inheres in lateral rectus extra-ocular muscle [Term] id: OBA:1000394 @@ -162844,8 +262199,8 @@ def: "The quality of a proximal epiphysis of humerus." [AUTO:patterns/patterns/e synonym: "quality of proximal epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004411 ! proximal epiphysis of humerus -relationship: inheres_in UBERON:0004411 ! proximal epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004411 ! inheres in proximal epiphysis of humerus +relationship: RO:0000052 UBERON:0004411 ! inheres in proximal epiphysis of humerus [Term] id: OBA:1000395 @@ -162854,8 +262209,8 @@ def: "The quality of a threonine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of threonine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000596 ! aspartate family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006566 ! threonine metabolic process -relationship: inheres_in GO:0006566 ! threonine metabolic process +intersection_of: RO:0000052 GO:0006566 ! inheres in threonine metabolic process +relationship: RO:0000052 GO:0006566 ! inheres in threonine metabolic process [Term] id: OBA:1000396 @@ -162864,8 +262219,8 @@ def: "The quality of a pupil." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001771 ! pupil -relationship: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil +relationship: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:1000397 @@ -162874,8 +262229,8 @@ def: "The quality of a humeroulnar joint." [AUTO:patterns/patterns/entity_attrib synonym: "quality of humeroulnar joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011110 ! humeroulnar joint -relationship: inheres_in UBERON:0011110 ! humeroulnar joint +intersection_of: RO:0000052 UBERON:0011110 ! inheres in humeroulnar joint +relationship: RO:0000052 UBERON:0011110 ! inheres in humeroulnar joint [Term] id: OBA:1000398 @@ -162884,8 +262239,8 @@ def: "The quality of a musculature of neck." [AUTO:patterns/patterns/entity_attr synonym: "quality of musculature of neck" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004465 ! musculature of neck -relationship: inheres_in UBERON:0004465 ! musculature of neck +intersection_of: RO:0000052 UBERON:0004465 ! inheres in musculature of neck +relationship: RO:0000052 UBERON:0004465 ! inheres in musculature of neck [Term] id: OBA:1000399 @@ -162894,8 +262249,8 @@ def: "The quality of a distal epiphysis of fibula." [AUTO:patterns/patterns/enti synonym: "quality of distal epiphysis of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000331 ! epiphysis of fibula quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004410 ! distal epiphysis of fibula -relationship: inheres_in UBERON:0004410 ! distal epiphysis of fibula +intersection_of: RO:0000052 UBERON:0004410 ! inheres in distal epiphysis of fibula +relationship: RO:0000052 UBERON:0004410 ! inheres in distal epiphysis of fibula [Term] id: OBA:1000400 @@ -162905,8 +262260,8 @@ synonym: "quality of irritability behavior" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000407 ! social behavior quality is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000128 ! irritability behavior -relationship: inheres_in NBO:0000128 ! irritability behavior +intersection_of: RO:0000052 NBO:0000128 ! inheres in irritability behavior +relationship: RO:0000052 NBO:0000128 ! inheres in irritability behavior [Term] id: OBA:1000401 @@ -162915,8 +262270,8 @@ def: "The quality of a mouth mucosa." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of mouth mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003729 ! mouth mucosa -relationship: inheres_in UBERON:0003729 ! mouth mucosa +intersection_of: RO:0000052 UBERON:0003729 ! inheres in mouth mucosa +relationship: RO:0000052 UBERON:0003729 ! inheres in mouth mucosa [Term] id: OBA:1000402 @@ -162925,8 +262280,8 @@ def: "The quality of a mastoid process of temporal bone." [AUTO:patterns/pattern synonym: "quality of mastoid process of temporal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011220 ! mastoid process of temporal bone -relationship: inheres_in UBERON:0011220 ! mastoid process of temporal bone +intersection_of: RO:0000052 UBERON:0011220 ! inheres in mastoid process of temporal bone +relationship: RO:0000052 UBERON:0011220 ! inheres in mastoid process of temporal bone [Term] id: OBA:1000403 @@ -162935,8 +262290,8 @@ def: "The quality of a lobule of pinna." [AUTO:patterns/patterns/entity_attribut synonym: "quality of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna -relationship: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna +relationship: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:1000404 @@ -162945,8 +262300,8 @@ def: "The quality of a proteoglycan metabolic process." [AUTO:patterns/patterns/ synonym: "quality of proteoglycan metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006029 ! proteoglycan metabolic process -relationship: inheres_in GO:0006029 ! proteoglycan metabolic process +intersection_of: RO:0000052 GO:0006029 ! inheres in proteoglycan metabolic process +relationship: RO:0000052 GO:0006029 ! inheres in proteoglycan metabolic process [Term] id: OBA:1000405 @@ -162955,8 +262310,8 @@ def: "The quality of a hair of head." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hair of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0016446 ! hair of head -relationship: inheres_in UBERON:0016446 ! hair of head +intersection_of: RO:0000052 UBERON:0016446 ! inheres in hair of head +relationship: RO:0000052 UBERON:0016446 ! inheres in hair of head [Term] id: OBA:1000406 @@ -162965,8 +262320,8 @@ def: "The quality of a metencephalon." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of metencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001895 ! metencephalon -relationship: inheres_in UBERON:0001895 ! metencephalon +intersection_of: RO:0000052 UBERON:0001895 ! inheres in metencephalon +relationship: RO:0000052 UBERON:0001895 ! inheres in metencephalon [Term] id: OBA:1000407 @@ -162975,8 +262330,8 @@ def: "The quality of a social behavior." [AUTO:patterns/patterns/entity_attribut synonym: "quality of social behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000011 ! social behavior -relationship: inheres_in NBO:0000011 ! social behavior +intersection_of: RO:0000052 NBO:0000011 ! inheres in social behavior +relationship: RO:0000052 NBO:0000011 ! inheres in social behavior [Term] id: OBA:1000408 @@ -162985,8 +262340,8 @@ def: "The quality of a superior cerebellar peduncle of pons." [AUTO:patterns/pat synonym: "quality of superior cerebellar peduncle of pons" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007709 ! superior cerebellar peduncle of pons -relationship: inheres_in UBERON:0007709 ! superior cerebellar peduncle of pons +intersection_of: RO:0000052 UBERON:0007709 ! inheres in superior cerebellar peduncle of pons +relationship: RO:0000052 UBERON:0007709 ! inheres in superior cerebellar peduncle of pons [Term] id: OBA:1000409 @@ -162995,8 +262350,8 @@ def: "The quality of a glenoid fossa." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of glenoid fossa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006657 ! glenoid fossa -relationship: inheres_in UBERON:0006657 ! glenoid fossa +intersection_of: RO:0000052 UBERON:0006657 ! inheres in glenoid fossa +relationship: RO:0000052 UBERON:0006657 ! inheres in glenoid fossa [Term] id: OBA:1000410 @@ -163005,8 +262360,8 @@ def: "The quality of a iliac blade." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of iliac blade" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010746 ! iliac blade -relationship: inheres_in UBERON:0010746 ! iliac blade +intersection_of: RO:0000052 UBERON:0010746 ! inheres in iliac blade +relationship: RO:0000052 UBERON:0010746 ! inheres in iliac blade [Term] id: OBA:1000411 @@ -163015,8 +262370,8 @@ def: "The quality of a palatopharyngeus muscle." [AUTO:patterns/patterns/entity_ synonym: "quality of palatopharyngeus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010234 ! palatopharyngeus muscle -relationship: inheres_in UBERON:0010234 ! palatopharyngeus muscle +intersection_of: RO:0000052 UBERON:0010234 ! inheres in palatopharyngeus muscle +relationship: RO:0000052 UBERON:0010234 ! inheres in palatopharyngeus muscle [Term] id: OBA:1000412 @@ -163025,8 +262380,8 @@ def: "The quality of a diencephalon." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of diencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001894 ! diencephalon -relationship: inheres_in UBERON:0001894 ! diencephalon +intersection_of: RO:0000052 UBERON:0001894 ! inheres in diencephalon +relationship: RO:0000052 UBERON:0001894 ! inheres in diencephalon [Term] id: OBA:1000413 @@ -163035,8 +262390,8 @@ def: "The quality of a metatarsal bone of digit 3." [AUTO:patterns/patterns/enti synonym: "quality of metatarsal bone of digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003652 ! metatarsal bone of digit 3 -relationship: inheres_in UBERON:0003652 ! metatarsal bone of digit 3 +intersection_of: RO:0000052 UBERON:0003652 ! inheres in metatarsal bone of digit 3 +relationship: RO:0000052 UBERON:0003652 ! inheres in metatarsal bone of digit 3 [Term] id: OBA:1000414 @@ -163045,8 +262400,8 @@ def: "The quality of a umbilical blood vessel." [AUTO:patterns/patterns/entity_a synonym: "quality of umbilical blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010260 ! umbilical blood vessel -relationship: inheres_in UBERON:0010260 ! umbilical blood vessel +intersection_of: RO:0000052 UBERON:0010260 ! inheres in umbilical blood vessel +relationship: RO:0000052 UBERON:0010260 ! inheres in umbilical blood vessel [Term] id: OBA:1000415 @@ -163055,8 +262410,8 @@ def: "The quality of a DNA repair." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of DNA repair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006281 ! DNA repair -relationship: inheres_in GO:0006281 ! DNA repair +intersection_of: RO:0000052 GO:0006281 ! inheres in DNA repair +relationship: RO:0000052 GO:0006281 ! inheres in DNA repair [Term] id: OBA:1000416 @@ -163065,8 +262420,8 @@ def: "The quality of a ischium." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ischium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001274 ! ischium -relationship: inheres_in UBERON:0001274 ! ischium +intersection_of: RO:0000052 UBERON:0001274 ! inheres in ischium +relationship: RO:0000052 UBERON:0001274 ! inheres in ischium [Term] id: OBA:1000417 @@ -163075,8 +262430,8 @@ def: "The quality of a temporomandibular joint." [AUTO:patterns/patterns/entity_ synonym: "quality of temporomandibular joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003700 ! temporomandibular joint -relationship: inheres_in UBERON:0003700 ! temporomandibular joint +intersection_of: RO:0000052 UBERON:0003700 ! inheres in temporomandibular joint +relationship: RO:0000052 UBERON:0003700 ! inheres in temporomandibular joint [Term] id: OBA:1000418 @@ -163085,8 +262440,8 @@ def: "The quality of a T cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000084 ! T cell -relationship: inheres_in CL:0000084 ! T cell +intersection_of: RO:0000052 CL:0000084 ! inheres in T cell +relationship: RO:0000052 CL:0000084 ! inheres in T cell [Term] id: OBA:1000419 @@ -163096,8 +262451,8 @@ synonym: "quality of middle phalanx of pedal digit 3" EXACT [AUTO:patterns/patte is_a: OBA:1000378 ! pedal digit 3 phalanx quality is_a: OBA:1000492 ! middle phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004325 ! middle phalanx of pedal digit 3 -relationship: inheres_in UBERON:0004325 ! middle phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004325 ! inheres in middle phalanx of pedal digit 3 +relationship: RO:0000052 UBERON:0004325 ! inheres in middle phalanx of pedal digit 3 [Term] id: OBA:1000420 @@ -163106,18 +262461,18 @@ def: "The quality of a inferior alveolar nerve." [AUTO:patterns/patterns/entity_ synonym: "quality of inferior alveolar nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0018405 ! inferior alveolar nerve -relationship: inheres_in UBERON:0018405 ! inferior alveolar nerve +intersection_of: RO:0000052 UBERON:0018405 ! inheres in inferior alveolar nerve +relationship: RO:0000052 UBERON:0018405 ! inheres in inferior alveolar nerve [Term] id: OBA:1000421 -name: chromosome breakage quality -def: "The quality of a chromosome breakage." [AUTO:patterns/patterns/entity_attribute] -synonym: "quality of chromosome breakage" EXACT [AUTO:patterns/patterns/entity_attribute] +name: programmed DNA elimination by chromosome breakage quality +def: "The quality of a programmed DNA elimination by chromosome breakage." [AUTO:patterns/patterns/entity_attribute] +synonym: "quality of programmed DNA elimination by chromosome breakage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0031052 ! chromosome breakage -relationship: inheres_in GO:0031052 ! chromosome breakage +intersection_of: RO:0000052 GO:0031052 ! inheres in programmed DNA elimination by chromosome breakage +relationship: RO:0000052 GO:0031052 ! inheres in programmed DNA elimination by chromosome breakage [Term] id: OBA:1000422 @@ -163127,8 +262482,8 @@ synonym: "quality of proximal phalanx of pedal digit 3" EXACT [AUTO:patterns/pat is_a: OBA:1000212 ! proximal phalanx of pes quality is_a: OBA:1000378 ! pedal digit 3 phalanx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004334 ! proximal phalanx of pedal digit 3 -relationship: inheres_in UBERON:0004334 ! proximal phalanx of pedal digit 3 +intersection_of: RO:0000052 UBERON:0004334 ! inheres in proximal phalanx of pedal digit 3 +relationship: RO:0000052 UBERON:0004334 ! inheres in proximal phalanx of pedal digit 3 [Term] id: OBA:1000423 @@ -163137,8 +262492,8 @@ def: "The quality of a distal segment of manual digit." [AUTO:patterns/patterns/ synonym: "quality of distal segment of manual digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0009552 ! distal segment of manual digit -relationship: inheres_in UBERON:0009552 ! distal segment of manual digit +intersection_of: RO:0000052 UBERON:0009552 ! inheres in distal segment of manual digit +relationship: RO:0000052 UBERON:0009552 ! inheres in distal segment of manual digit [Term] id: OBA:1000424 @@ -163147,8 +262502,8 @@ def: "The quality of a lacrimal punctum." [AUTO:patterns/patterns/entity_attribu synonym: "quality of lacrimal punctum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010284 ! lacrimal punctum -relationship: inheres_in UBERON:0010284 ! lacrimal punctum +intersection_of: RO:0000052 UBERON:0010284 ! inheres in lacrimal punctum +relationship: RO:0000052 UBERON:0010284 ! inheres in lacrimal punctum [Term] id: OBA:1000425 @@ -163157,8 +262512,8 @@ def: "The quality of a jaw muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of jaw muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011648 ! jaw muscle -relationship: inheres_in UBERON:0011648 ! jaw muscle +intersection_of: RO:0000052 UBERON:0011648 ! inheres in jaw muscle +relationship: RO:0000052 UBERON:0011648 ! inheres in jaw muscle [Term] id: OBA:1000426 @@ -163167,8 +262522,8 @@ def: "The quality of a neurohypophysis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis -relationship: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis +relationship: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:1000427 @@ -163178,8 +262533,8 @@ synonym: "quality of distal phalanx of pedal digit 2" EXACT [AUTO:patterns/patte is_a: OBA:1000353 ! pedal digit 2 phalanx quality is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 -relationship: inheres_in UBERON:0004316 ! distal phalanx of pedal digit 2 +intersection_of: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 +relationship: RO:0000052 UBERON:0004316 ! inheres in distal phalanx of pedal digit 2 [Term] id: OBA:1000428 @@ -163188,8 +262543,8 @@ def: "The quality of a L-phenylalanine metabolic process." [AUTO:patterns/patter synonym: "quality of L-phenylalanine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000348 ! aromatic amino acid family metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006558 ! L-phenylalanine metabolic process -relationship: inheres_in GO:0006558 ! L-phenylalanine metabolic process +intersection_of: RO:0000052 GO:0006558 ! inheres in L-phenylalanine metabolic process +relationship: RO:0000052 GO:0006558 ! inheres in L-phenylalanine metabolic process [Term] id: OBA:1000429 @@ -163198,8 +262553,8 @@ def: "The quality of a skull." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of skull" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003129 ! skull -relationship: inheres_in UBERON:0003129 ! skull +intersection_of: RO:0000052 UBERON:0003129 ! inheres in skull +relationship: RO:0000052 UBERON:0003129 ! inheres in skull [Term] id: OBA:1000430 @@ -163208,8 +262563,8 @@ def: "The quality of a masseter muscle." [AUTO:patterns/patterns/entity_attribut synonym: "quality of masseter muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000322 ! masticatory muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001597 ! masseter muscle -relationship: inheres_in UBERON:0001597 ! masseter muscle +intersection_of: RO:0000052 UBERON:0001597 ! inheres in masseter muscle +relationship: RO:0000052 UBERON:0001597 ! inheres in masseter muscle [Term] id: OBA:1000431 @@ -163218,8 +262573,8 @@ def: "The quality of a cochlear nerve." [AUTO:patterns/patterns/entity_attribute synonym: "quality of cochlear nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004727 ! cochlear nerve -relationship: inheres_in UBERON:0004727 ! cochlear nerve +intersection_of: RO:0000052 UBERON:0004727 ! inheres in cochlear nerve +relationship: RO:0000052 UBERON:0004727 ! inheres in cochlear nerve [Term] id: OBA:1000432 @@ -163228,8 +262583,8 @@ def: "The quality of a internal jugular vein." [AUTO:patterns/patterns/entity_at synonym: "quality of internal jugular vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000252 ! jugular vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001586 ! internal jugular vein -relationship: inheres_in UBERON:0001586 ! internal jugular vein +intersection_of: RO:0000052 UBERON:0001586 ! inheres in internal jugular vein +relationship: RO:0000052 UBERON:0001586 ! inheres in internal jugular vein [Term] id: OBA:1000433 @@ -163238,8 +262593,8 @@ def: "The quality of a lateral pterygoid muscle." [AUTO:patterns/patterns/entity synonym: "quality of lateral pterygoid muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000322 ! masticatory muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006719 ! lateral pterygoid muscle -relationship: inheres_in UBERON:0006719 ! lateral pterygoid muscle +intersection_of: RO:0000052 UBERON:0006719 ! inheres in lateral pterygoid muscle +relationship: RO:0000052 UBERON:0006719 ! inheres in lateral pterygoid muscle [Term] id: OBA:1000434 @@ -163248,8 +262603,8 @@ def: "The quality of a chloride ion homeostasis." [AUTO:patterns/patterns/entity synonym: "quality of chloride ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001765 ! ion homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055064 ! chloride ion homeostasis -relationship: inheres_in GO:0055064 ! chloride ion homeostasis +intersection_of: RO:0000052 GO:0055064 ! inheres in chloride ion homeostasis +relationship: RO:0000052 GO:0055064 ! inheres in chloride ion homeostasis [Term] id: OBA:1000435 @@ -163258,8 +262613,8 @@ def: "The quality of a meninx." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of meninx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002360 ! meninx -relationship: inheres_in UBERON:0002360 ! meninx +intersection_of: RO:0000052 UBERON:0002360 ! inheres in meninx +relationship: RO:0000052 UBERON:0002360 ! inheres in meninx [Term] id: OBA:1000436 @@ -163268,8 +262623,8 @@ def: "The quality of a molar tooth." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of molar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003655 ! molar tooth -relationship: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth +relationship: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:1000437 @@ -163278,8 +262633,8 @@ def: "The quality of a lacrimal gland." [AUTO:patterns/patterns/entity_attribute synonym: "quality of lacrimal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001817 ! lacrimal gland -relationship: inheres_in UBERON:0001817 ! lacrimal gland +intersection_of: RO:0000052 UBERON:0001817 ! inheres in lacrimal gland +relationship: RO:0000052 UBERON:0001817 ! inheres in lacrimal gland [Term] id: OBA:1000438 @@ -163288,8 +262643,8 @@ def: "The quality of a intrahepatic bile duct." [AUTO:patterns/patterns/entity_a synonym: "quality of intrahepatic bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003704 ! intrahepatic bile duct -relationship: inheres_in UBERON:0003704 ! intrahepatic bile duct +intersection_of: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct +relationship: RO:0000052 UBERON:0003704 ! inheres in intrahepatic bile duct [Term] id: OBA:1000439 @@ -163298,8 +262653,8 @@ def: "The quality of a Descemet's membrane." [AUTO:patterns/patterns/entity_attr synonym: "quality of Descemet's membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004367 ! Descemet's membrane -relationship: inheres_in UBERON:0004367 ! Descemet's membrane +intersection_of: RO:0000052 UBERON:0004367 ! inheres in Descemet's membrane +relationship: RO:0000052 UBERON:0004367 ! inheres in Descemet's membrane [Term] id: OBA:1000440 @@ -163308,8 +262663,8 @@ def: "The quality of a interphalangeal joint of manus." [AUTO:patterns/patterns/ synonym: "quality of interphalangeal joint of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000699 ! interphalangeal joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007722 ! interphalangeal joint of manus -relationship: inheres_in UBERON:0007722 ! interphalangeal joint of manus +intersection_of: RO:0000052 UBERON:0007722 ! inheres in interphalangeal joint of manus +relationship: RO:0000052 UBERON:0007722 ! inheres in interphalangeal joint of manus [Term] id: OBA:1000441 @@ -163323,8 +262678,8 @@ def: "The quality of a cerebellar peduncle." [AUTO:patterns/patterns/entity_attr synonym: "quality of cerebellar peduncle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007416 ! cerebellar peduncle -relationship: inheres_in UBERON:0007416 ! cerebellar peduncle +intersection_of: RO:0000052 UBERON:0007416 ! inheres in cerebellar peduncle +relationship: RO:0000052 UBERON:0007416 ! inheres in cerebellar peduncle [Term] id: OBA:1000443 @@ -163333,8 +262688,8 @@ def: "The quality of a physical aggression behavior." [AUTO:patterns/patterns/en synonym: "quality of physical aggression behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000376 ! aggressive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000120 ! physical aggression behavior -relationship: inheres_in NBO:0000120 ! physical aggression behavior +intersection_of: RO:0000052 NBO:0000120 ! inheres in physical aggression behavior +relationship: RO:0000052 NBO:0000120 ! inheres in physical aggression behavior [Term] id: OBA:1000444 @@ -163343,8 +262698,8 @@ def: "The quality of a outflow part of left ventricle." [AUTO:patterns/patterns/ synonym: "quality of outflow part of left ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005956 ! outflow part of left ventricle -relationship: inheres_in UBERON:0005956 ! outflow part of left ventricle +intersection_of: RO:0000052 UBERON:0005956 ! inheres in outflow part of left ventricle +relationship: RO:0000052 UBERON:0005956 ! inheres in outflow part of left ventricle [Term] id: OBA:1000445 @@ -163353,8 +262708,8 @@ def: "The quality of a tibial plateaux." [AUTO:patterns/patterns/entity_attribut synonym: "quality of tibial plateaux" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004098 ! tibial plateaux -relationship: inheres_in UBERON:0004098 ! tibial plateaux +intersection_of: RO:0000052 UBERON:0004098 ! inheres in tibial plateaux +relationship: RO:0000052 UBERON:0004098 ! inheres in tibial plateaux [Term] id: OBA:1000446 @@ -163363,8 +262718,8 @@ def: "The quality of a pedal digit 3." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pedal digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000314 ! pedal digit quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003633 ! pedal digit 3 -relationship: inheres_in UBERON:0003633 ! pedal digit 3 +intersection_of: RO:0000052 UBERON:0003633 ! inheres in pedal digit 3 +relationship: RO:0000052 UBERON:0003633 ! inheres in pedal digit 3 [Term] id: OBA:1000447 @@ -163373,8 +262728,8 @@ def: "The quality of a plantar part of pes." [AUTO:patterns/patterns/entity_attr synonym: "quality of plantar part of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008338 ! plantar part of pes -relationship: inheres_in UBERON:0008338 ! plantar part of pes +intersection_of: RO:0000052 UBERON:0008338 ! inheres in plantar part of pes +relationship: RO:0000052 UBERON:0008338 ! inheres in plantar part of pes [Term] id: OBA:1000448 @@ -163383,8 +262738,8 @@ def: "The quality of a alkaline phosphatase activity." [AUTO:patterns/patterns/e synonym: "quality of alkaline phosphatase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004035 ! alkaline phosphatase activity -relationship: inheres_in GO:0004035 ! alkaline phosphatase activity +intersection_of: RO:0000052 GO:0004035 ! inheres in alkaline phosphatase activity +relationship: RO:0000052 GO:0004035 ! inheres in alkaline phosphatase activity [Term] id: OBA:1000449 @@ -163393,8 +262748,8 @@ def: "The quality of a talus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of talus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000508 ! tarsal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002395 ! talus -relationship: inheres_in UBERON:0002395 ! talus +intersection_of: RO:0000052 UBERON:0002395 ! inheres in talus +relationship: RO:0000052 UBERON:0002395 ! inheres in talus [Term] id: OBA:1000450 @@ -163403,8 +262758,8 @@ def: "The quality of a facial skeleton." [AUTO:patterns/patterns/entity_attribut synonym: "quality of facial skeleton" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011156 ! facial skeleton -relationship: inheres_in UBERON:0011156 ! facial skeleton +intersection_of: RO:0000052 UBERON:0011156 ! inheres in facial skeleton +relationship: RO:0000052 UBERON:0011156 ! inheres in facial skeleton [Term] id: OBA:1000451 @@ -163414,8 +262769,8 @@ synonym: "quality of main ciliary ganglion" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000203 ! cranial ganglion quality is_a: OBA:1000531 ! ganglion of peripheral nervous system quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002058 ! main ciliary ganglion -relationship: inheres_in UBERON:0002058 ! main ciliary ganglion +intersection_of: RO:0000052 UBERON:0002058 ! inheres in main ciliary ganglion +relationship: RO:0000052 UBERON:0002058 ! inheres in main ciliary ganglion [Term] id: OBA:1000452 @@ -163424,8 +262779,8 @@ def: "The quality of a carbohydrate metabolic process." [AUTO:patterns/patterns/ synonym: "quality of carbohydrate metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005975 ! carbohydrate metabolic process -relationship: inheres_in GO:0005975 ! carbohydrate metabolic process +intersection_of: RO:0000052 GO:0005975 ! inheres in carbohydrate metabolic process +relationship: RO:0000052 GO:0005975 ! inheres in carbohydrate metabolic process [Term] id: OBA:1000453 @@ -163434,8 +262789,8 @@ def: "The quality of a internal acoustic meatus." [AUTO:patterns/patterns/entity synonym: "quality of internal acoustic meatus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011859 ! internal acoustic meatus -relationship: inheres_in UBERON:0011859 ! internal acoustic meatus +intersection_of: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus +relationship: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus [Term] id: OBA:1000454 @@ -163444,8 +262799,8 @@ def: "The quality of a nasal bone." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of nasal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000064 ! dermal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001681 ! nasal bone -relationship: inheres_in UBERON:0001681 ! nasal bone +intersection_of: RO:0000052 UBERON:0001681 ! inheres in nasal bone +relationship: RO:0000052 UBERON:0001681 ! inheres in nasal bone [Term] id: OBA:1000455 @@ -163454,8 +262809,8 @@ def: "The quality of a zinc ion homeostasis." [AUTO:patterns/patterns/entity_att synonym: "quality of zinc ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000323 ! divalent inorganic cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055069 ! zinc ion homeostasis -relationship: inheres_in GO:0055069 ! zinc ion homeostasis +intersection_of: RO:0000052 GO:0055069 ! inheres in zinc ion homeostasis +relationship: RO:0000052 GO:0055069 ! inheres in zinc ion homeostasis [Term] id: OBA:1000456 @@ -163464,8 +262819,8 @@ def: "The quality of a corpus cavernosum." [AUTO:patterns/patterns/entity_attrib synonym: "quality of corpus cavernosum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006609 ! corpus cavernosum -relationship: inheres_in UBERON:0006609 ! corpus cavernosum +intersection_of: RO:0000052 UBERON:0006609 ! inheres in corpus cavernosum +relationship: RO:0000052 UBERON:0006609 ! inheres in corpus cavernosum [Term] id: OBA:1000457 @@ -163474,8 +262829,8 @@ def: "The quality of a zygomaticus minor muscle." [AUTO:patterns/patterns/entity synonym: "quality of zygomaticus minor muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008594 ! zygomaticus minor muscle -relationship: inheres_in UBERON:0008594 ! zygomaticus minor muscle +intersection_of: RO:0000052 UBERON:0008594 ! inheres in zygomaticus minor muscle +relationship: RO:0000052 UBERON:0008594 ! inheres in zygomaticus minor muscle [Term] id: OBA:1000458 @@ -163484,8 +262839,8 @@ def: "The quality of a hindlimb zeugopod muscle." [AUTO:patterns/patterns/entity synonym: "quality of hindlimb zeugopod muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004256 ! hindlimb zeugopod muscle -relationship: inheres_in UBERON:0004256 ! hindlimb zeugopod muscle +intersection_of: RO:0000052 UBERON:0004256 ! inheres in hindlimb zeugopod muscle +relationship: RO:0000052 UBERON:0004256 ! inheres in hindlimb zeugopod muscle [Term] id: OBA:1000459 @@ -163494,8 +262849,8 @@ def: "The quality of a skin of body." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of skin of body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002097 ! skin of body -relationship: inheres_in UBERON:0002097 ! skin of body +intersection_of: RO:0000052 UBERON:0002097 ! inheres in skin of body +relationship: RO:0000052 UBERON:0002097 ! inheres in skin of body [Term] id: OBA:1000460 @@ -163504,8 +262859,8 @@ def: "The quality of a vasculature of iris." [AUTO:patterns/patterns/entity_attr synonym: "quality of vasculature of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000156 ! vasculature of eye quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004118 ! vasculature of iris -relationship: inheres_in UBERON:0004118 ! vasculature of iris +intersection_of: RO:0000052 UBERON:0004118 ! inheres in vasculature of iris +relationship: RO:0000052 UBERON:0004118 ! inheres in vasculature of iris [Term] id: OBA:1000461 @@ -163515,8 +262870,8 @@ synonym: "quality of proximal phalanx of pedal digit 1" EXACT [AUTO:patterns/pat is_a: OBA:1000161 ! pedal digit 1 phalanx quality is_a: OBA:1000212 ! proximal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 -relationship: inheres_in UBERON:0004332 ! proximal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 +relationship: RO:0000052 UBERON:0004332 ! inheres in proximal phalanx of pedal digit 1 [Term] id: OBA:1000462 @@ -163525,8 +262880,8 @@ def: "The quality of a hard palate." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hard palate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003216 ! hard palate -relationship: inheres_in UBERON:0003216 ! hard palate +intersection_of: RO:0000052 UBERON:0003216 ! inheres in hard palate +relationship: RO:0000052 UBERON:0003216 ! inheres in hard palate [Term] id: OBA:1000463 @@ -163535,8 +262890,8 @@ def: "The quality of a arch of aorta." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of arch of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001508 ! arch of aorta -relationship: inheres_in UBERON:0001508 ! arch of aorta +intersection_of: RO:0000052 UBERON:0001508 ! inheres in arch of aorta +relationship: RO:0000052 UBERON:0001508 ! inheres in arch of aorta [Term] id: OBA:1000464 @@ -163545,8 +262900,8 @@ def: "The quality of a impulsive behavior." [AUTO:patterns/patterns/entity_attri synonym: "quality of impulsive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000119 ! impulsive behavior -relationship: inheres_in NBO:0000119 ! impulsive behavior +intersection_of: RO:0000052 NBO:0000119 ! inheres in impulsive behavior +relationship: RO:0000052 NBO:0000119 ! inheres in impulsive behavior [Term] id: OBA:1000465 @@ -163555,8 +262910,8 @@ def: "The quality of a upper respiratory tract." [AUTO:patterns/patterns/entity_ synonym: "quality of upper respiratory tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001557 ! upper respiratory tract -relationship: inheres_in UBERON:0001557 ! upper respiratory tract +intersection_of: RO:0000052 UBERON:0001557 ! inheres in upper respiratory tract +relationship: RO:0000052 UBERON:0001557 ! inheres in upper respiratory tract [Term] id: OBA:1000466 @@ -163565,8 +262920,8 @@ def: "The quality of a glycosphingolipid metabolic process." [AUTO:patterns/patt synonym: "quality of glycosphingolipid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000343 ! glycolipid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006687 ! glycosphingolipid metabolic process -relationship: inheres_in GO:0006687 ! glycosphingolipid metabolic process +intersection_of: RO:0000052 GO:0006687 ! inheres in glycosphingolipid metabolic process +relationship: RO:0000052 GO:0006687 ! inheres in glycosphingolipid metabolic process [Term] id: OBA:1000467 @@ -163575,8 +262930,8 @@ def: "The quality of a fourth ventricle." [AUTO:patterns/patterns/entity_attribu synonym: "quality of fourth ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000285 ! brain ventricle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002422 ! fourth ventricle -relationship: inheres_in UBERON:0002422 ! fourth ventricle +intersection_of: RO:0000052 UBERON:0002422 ! inheres in fourth ventricle +relationship: RO:0000052 UBERON:0002422 ! inheres in fourth ventricle [Term] id: OBA:1000468 @@ -163586,8 +262941,8 @@ synonym: "quality of distal phalanx of pedal digit 4" EXACT [AUTO:patterns/patte is_a: OBA:1000575 ! pedal digit 4 phalanx quality is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004318 ! distal phalanx of pedal digit 4 -relationship: inheres_in UBERON:0004318 ! distal phalanx of pedal digit 4 +intersection_of: RO:0000052 UBERON:0004318 ! inheres in distal phalanx of pedal digit 4 +relationship: RO:0000052 UBERON:0004318 ! inheres in distal phalanx of pedal digit 4 [Term] id: OBA:1000469 @@ -163596,8 +262951,8 @@ def: "The quality of a buccinator muscle." [AUTO:patterns/patterns/entity_attrib synonym: "quality of buccinator muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001582 ! buccinator muscle -relationship: inheres_in UBERON:0001582 ! buccinator muscle +intersection_of: RO:0000052 UBERON:0001582 ! inheres in buccinator muscle +relationship: RO:0000052 UBERON:0001582 ! inheres in buccinator muscle [Term] id: OBA:1000470 @@ -163606,8 +262961,8 @@ def: "The quality of a radio-ulnar joint." [AUTO:patterns/patterns/entity_attrib synonym: "quality of radio-ulnar joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001528 ! radio-ulnar joint -relationship: inheres_in UBERON:0001528 ! radio-ulnar joint +intersection_of: RO:0000052 UBERON:0001528 ! inheres in radio-ulnar joint +relationship: RO:0000052 UBERON:0001528 ! inheres in radio-ulnar joint [Term] id: OBA:1000471 @@ -163616,8 +262971,8 @@ def: "The quality of a nerve." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001021 ! nerve -relationship: inheres_in UBERON:0001021 ! nerve +intersection_of: RO:0000052 UBERON:0001021 ! inheres in nerve +relationship: RO:0000052 UBERON:0001021 ! inheres in nerve [Term] id: OBA:1000472 @@ -163626,8 +262981,8 @@ def: "The quality of a histidine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of histidine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006547 ! histidine metabolic process -relationship: inheres_in GO:0006547 ! histidine metabolic process +intersection_of: RO:0000052 GO:0006547 ! inheres in histidine metabolic process +relationship: RO:0000052 GO:0006547 ! inheres in histidine metabolic process [Term] id: OBA:1000473 @@ -163636,8 +262991,8 @@ def: "The quality of a menstruation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of menstruation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042703 ! menstruation -relationship: inheres_in GO:0042703 ! menstruation +intersection_of: RO:0000052 GO:0042703 ! inheres in menstruation +relationship: RO:0000052 GO:0042703 ! inheres in menstruation [Term] id: OBA:1000474 @@ -163646,8 +263001,8 @@ def: "The quality of a lip." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015052 ! surface structure trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001833 ! lip -relationship: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip +relationship: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:1000475 @@ -163656,8 +263011,8 @@ def: "The quality of a frontalis muscle belly." [AUTO:patterns/patterns/entity_a synonym: "quality of frontalis muscle belly" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010952 ! frontalis muscle belly -relationship: inheres_in UBERON:0010952 ! frontalis muscle belly +intersection_of: RO:0000052 UBERON:0010952 ! inheres in frontalis muscle belly +relationship: RO:0000052 UBERON:0010952 ! inheres in frontalis muscle belly [Term] id: OBA:1000476 @@ -163666,8 +263021,8 @@ def: "The quality of a inferior alveolar artery." [AUTO:patterns/patterns/entity synonym: "quality of inferior alveolar artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0014693 ! inferior alveolar artery -relationship: inheres_in UBERON:0014693 ! inferior alveolar artery +intersection_of: RO:0000052 UBERON:0014693 ! inheres in inferior alveolar artery +relationship: RO:0000052 UBERON:0014693 ! inheres in inferior alveolar artery [Term] id: OBA:1000477 @@ -163676,8 +263031,8 @@ def: "The quality of a conjunctiva." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of conjunctiva" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001811 ! conjunctiva -relationship: inheres_in UBERON:0001811 ! conjunctiva +intersection_of: RO:0000052 UBERON:0001811 ! inheres in conjunctiva +relationship: RO:0000052 UBERON:0001811 ! inheres in conjunctiva [Term] id: OBA:1000478 @@ -163686,8 +263041,8 @@ def: "The quality of a branched-chain amino acid metabolic process." [AUTO:patte synonym: "quality of branched-chain amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009081 ! branched-chain amino acid metabolic process -relationship: inheres_in GO:0009081 ! branched-chain amino acid metabolic process +intersection_of: RO:0000052 GO:0009081 ! inheres in branched-chain amino acid metabolic process +relationship: RO:0000052 GO:0009081 ! inheres in branched-chain amino acid metabolic process [Term] id: OBA:1000479 @@ -163696,8 +263051,8 @@ def: "The quality of a vertebral endplate." [AUTO:patterns/patterns/entity_attri synonym: "quality of vertebral endplate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0014386 ! vertebral endplate -relationship: inheres_in UBERON:0014386 ! vertebral endplate +intersection_of: RO:0000052 UBERON:0014386 ! inheres in vertebral endplate +relationship: RO:0000052 UBERON:0014386 ! inheres in vertebral endplate [Term] id: OBA:1000480 @@ -163708,8 +263063,8 @@ is_a: OBA:1000452 ! carbohydrate metabolic process quality is_a: OBA:1000583 ! carboxylic acid metabolic process quality is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0019852 ! L-ascorbic acid metabolic process -relationship: inheres_in GO:0019852 ! L-ascorbic acid metabolic process +intersection_of: RO:0000052 GO:0019852 ! inheres in L-ascorbic acid metabolic process +relationship: RO:0000052 GO:0019852 ! inheres in L-ascorbic acid metabolic process [Term] id: OBA:1000481 @@ -163718,8 +263073,8 @@ def: "The quality of a placental membrane." [AUTO:patterns/patterns/entity_attri synonym: "quality of placental membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0009002 ! placental membrane -relationship: inheres_in UBERON:0009002 ! placental membrane +intersection_of: RO:0000052 UBERON:0009002 ! inheres in placental membrane +relationship: RO:0000052 UBERON:0009002 ! inheres in placental membrane [Term] id: OBA:1000482 @@ -163728,8 +263083,8 @@ def: "The quality of a myelinating Schwann cell." [AUTO:patterns/patterns/entity synonym: "quality of myelinating Schwann cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000236 ! glial cell quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000218 ! myelinating Schwann cell -relationship: inheres_in CL:0000218 ! myelinating Schwann cell +intersection_of: RO:0000052 CL:0000218 ! inheres in myelinating Schwann cell +relationship: RO:0000052 CL:0000218 ! inheres in myelinating Schwann cell [Term] id: OBA:1000483 @@ -163738,8 +263093,8 @@ def: "The quality of a ophthalmic artery." [AUTO:patterns/patterns/entity_attrib synonym: "quality of ophthalmic artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001619 ! ophthalmic artery -relationship: inheres_in UBERON:0001619 ! ophthalmic artery +intersection_of: RO:0000052 UBERON:0001619 ! inheres in ophthalmic artery +relationship: RO:0000052 UBERON:0001619 ! inheres in ophthalmic artery [Term] id: OBA:1000484 @@ -163748,8 +263103,8 @@ def: "The quality of a humeroradial joint." [AUTO:patterns/patterns/entity_attri synonym: "quality of humeroradial joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0011111 ! humeroradial joint -relationship: inheres_in UBERON:0011111 ! humeroradial joint +intersection_of: RO:0000052 UBERON:0011111 ! inheres in humeroradial joint +relationship: RO:0000052 UBERON:0011111 ! inheres in humeroradial joint [Term] id: OBA:1000485 @@ -163758,8 +263113,8 @@ def: "The quality of a pulmonary vein." [AUTO:patterns/patterns/entity_attribute synonym: "quality of pulmonary vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000292 ! vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002016 ! pulmonary vein -relationship: inheres_in UBERON:0002016 ! pulmonary vein +intersection_of: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein +relationship: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein [Term] id: OBA:1000486 @@ -163768,8 +263123,8 @@ def: "The quality of a tooth root." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tooth root" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003677 ! tooth root -relationship: inheres_in UBERON:0003677 ! tooth root +intersection_of: RO:0000052 UBERON:0003677 ! inheres in tooth root +relationship: RO:0000052 UBERON:0003677 ! inheres in tooth root [Term] id: OBA:1000487 @@ -163778,8 +263133,8 @@ def: "The quality of a palmar part of manus." [AUTO:patterns/patterns/entity_att synonym: "quality of palmar part of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008878 ! palmar part of manus -relationship: inheres_in UBERON:0008878 ! palmar part of manus +intersection_of: RO:0000052 UBERON:0008878 ! inheres in palmar part of manus +relationship: RO:0000052 UBERON:0008878 ! inheres in palmar part of manus [Term] id: OBA:1000488 @@ -163788,8 +263143,8 @@ def: "The quality of a calcium ion homeostasis." [AUTO:patterns/patterns/entity_ synonym: "quality of calcium ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000323 ! divalent inorganic cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055074 ! calcium ion homeostasis -relationship: inheres_in GO:0055074 ! calcium ion homeostasis +intersection_of: RO:0000052 GO:0055074 ! inheres in calcium ion homeostasis +relationship: RO:0000052 GO:0055074 ! inheres in calcium ion homeostasis [Term] id: OBA:1000489 @@ -163798,8 +263153,8 @@ def: "The quality of a central retinal artery." [AUTO:patterns/patterns/entity_a synonym: "quality of central retinal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001620 ! central retinal artery -relationship: inheres_in UBERON:0001620 ! central retinal artery +intersection_of: RO:0000052 UBERON:0001620 ! inheres in central retinal artery +relationship: RO:0000052 UBERON:0001620 ! inheres in central retinal artery [Term] id: OBA:1000490 @@ -163808,8 +263163,8 @@ def: "The quality of a corticospinal tract." [AUTO:patterns/patterns/entity_attr synonym: "quality of corticospinal tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002707 ! corticospinal tract -relationship: inheres_in UBERON:0002707 ! corticospinal tract +intersection_of: RO:0000052 UBERON:0002707 ! inheres in corticospinal tract +relationship: RO:0000052 UBERON:0002707 ! inheres in corticospinal tract [Term] id: OBA:1000491 @@ -163818,8 +263173,8 @@ def: "The quality of a metatarsal bone of digit 2." [AUTO:patterns/patterns/enti synonym: "quality of metatarsal bone of digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003651 ! metatarsal bone of digit 2 -relationship: inheres_in UBERON:0003651 ! metatarsal bone of digit 2 +intersection_of: RO:0000052 UBERON:0003651 ! inheres in metatarsal bone of digit 2 +relationship: RO:0000052 UBERON:0003651 ! inheres in metatarsal bone of digit 2 [Term] id: OBA:1000492 @@ -163828,8 +263183,8 @@ def: "The quality of a middle phalanx of pes." [AUTO:patterns/patterns/entity_at synonym: "quality of middle phalanx of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003866 ! middle phalanx of pes -relationship: inheres_in UBERON:0003866 ! middle phalanx of pes +intersection_of: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes +relationship: RO:0000052 UBERON:0003866 ! inheres in middle phalanx of pes [Term] id: OBA:1000493 @@ -163839,8 +263194,8 @@ synonym: "quality of visual pursuit" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000678 ! body part movement quality is_a: OBA:VT0002090 ! vision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000446 ! visual pursuit -relationship: inheres_in NBO:0000446 ! visual pursuit +intersection_of: RO:0000052 NBO:0000446 ! inheres in visual pursuit +relationship: RO:0000052 NBO:0000446 ! inheres in visual pursuit [Term] id: OBA:1000494 @@ -163849,8 +263204,8 @@ def: "The quality of a protein O-linked glycosylation." [AUTO:patterns/patterns/ synonym: "quality of protein O-linked glycosylation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000264 ! protein glycosylation quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006493 ! protein O-linked glycosylation -relationship: inheres_in GO:0006493 ! protein O-linked glycosylation +intersection_of: RO:0000052 GO:0006493 ! inheres in protein O-linked glycosylation +relationship: RO:0000052 GO:0006493 ! inheres in protein O-linked glycosylation [Term] id: OBA:1000495 @@ -163859,8 +263214,8 @@ def: "The quality of a circle of Willis." [AUTO:patterns/patterns/entity_attribu synonym: "quality of circle of Willis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003709 ! circle of Willis -relationship: inheres_in UBERON:0003709 ! circle of Willis +intersection_of: RO:0000052 UBERON:0003709 ! inheres in circle of Willis +relationship: RO:0000052 UBERON:0003709 ! inheres in circle of Willis [Term] id: OBA:1000496 @@ -163869,8 +263224,8 @@ def: "The quality of a midface." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of midface" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004089 ! midface -relationship: inheres_in UBERON:0004089 ! midface +intersection_of: RO:0000052 UBERON:0004089 ! inheres in midface +relationship: RO:0000052 UBERON:0004089 ! inheres in midface [Term] id: OBA:1000497 @@ -163879,8 +263234,8 @@ def: "The quality of a platysma." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of platysma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005467 ! platysma -relationship: inheres_in UBERON:0005467 ! platysma +intersection_of: RO:0000052 UBERON:0005467 ! inheres in platysma +relationship: RO:0000052 UBERON:0005467 ! inheres in platysma [Term] id: OBA:1000498 @@ -163889,8 +263244,8 @@ def: "The quality of a tyrosine metabolic process." [AUTO:patterns/patterns/enti synonym: "quality of tyrosine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000348 ! aromatic amino acid family metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006570 ! tyrosine metabolic process -relationship: inheres_in GO:0006570 ! tyrosine metabolic process +intersection_of: RO:0000052 GO:0006570 ! inheres in tyrosine metabolic process +relationship: RO:0000052 GO:0006570 ! inheres in tyrosine metabolic process [Term] id: OBA:1000499 @@ -163899,8 +263254,8 @@ def: "The quality of a sulfur amino acid metabolic process." [AUTO:patterns/patt synonym: "quality of sulfur amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0000096 ! sulfur amino acid metabolic process -relationship: inheres_in GO:0000096 ! sulfur amino acid metabolic process +intersection_of: RO:0000052 GO:0000096 ! inheres in sulfur amino acid metabolic process +relationship: RO:0000052 GO:0000096 ! inheres in sulfur amino acid metabolic process [Term] id: OBA:1000500 @@ -163909,8 +263264,8 @@ def: "The quality of a monovalent inorganic cation homeostasis." [AUTO:patterns/ synonym: "quality of monovalent inorganic cation homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000630 ! cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055067 ! monovalent inorganic cation homeostasis -relationship: inheres_in GO:0055067 ! monovalent inorganic cation homeostasis +intersection_of: RO:0000052 GO:0055067 ! inheres in monovalent inorganic cation homeostasis +relationship: RO:0000052 GO:0055067 ! inheres in monovalent inorganic cation homeostasis [Term] id: OBA:1000501 @@ -163919,8 +263274,8 @@ def: "The quality of a phalanx of pes." [AUTO:patterns/patterns/entity_attribute synonym: "quality of phalanx of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001449 ! phalanx of pes -relationship: inheres_in UBERON:0001449 ! phalanx of pes +intersection_of: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes +relationship: RO:0000052 UBERON:0001449 ! inheres in phalanx of pes [Term] id: OBA:1000502 @@ -163929,8 +263284,8 @@ def: "The quality of a isoleucine metabolic process." [AUTO:patterns/patterns/en synonym: "quality of isoleucine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000478 ! branched-chain amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006549 ! isoleucine metabolic process -relationship: inheres_in GO:0006549 ! isoleucine metabolic process +intersection_of: RO:0000052 GO:0006549 ! inheres in isoleucine metabolic process +relationship: RO:0000052 GO:0006549 ! inheres in isoleucine metabolic process [Term] id: OBA:1000503 @@ -163939,8 +263294,8 @@ def: "The quality of a hyoglossus muscle." [AUTO:patterns/patterns/entity_attrib synonym: "quality of hyoglossus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000286 ! extrinsic muscle of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001572 ! hyoglossus muscle -relationship: inheres_in UBERON:0001572 ! hyoglossus muscle +intersection_of: RO:0000052 UBERON:0001572 ! inheres in hyoglossus muscle +relationship: RO:0000052 UBERON:0001572 ! inheres in hyoglossus muscle [Term] id: OBA:1000504 @@ -163949,8 +263304,8 @@ def: "The quality of a temporalis muscle." [AUTO:patterns/patterns/entity_attrib synonym: "quality of temporalis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000322 ! masticatory muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001598 ! temporalis muscle -relationship: inheres_in UBERON:0001598 ! temporalis muscle +intersection_of: RO:0000052 UBERON:0001598 ! inheres in temporalis muscle +relationship: RO:0000052 UBERON:0001598 ! inheres in temporalis muscle [Term] id: OBA:1000505 @@ -163959,8 +263314,8 @@ def: "The quality of a renal system process." [AUTO:patterns/patterns/entity_att synonym: "quality of renal system process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003014 ! renal system process -relationship: inheres_in GO:0003014 ! renal system process +intersection_of: RO:0000052 GO:0003014 ! inheres in renal system process +relationship: RO:0000052 GO:0003014 ! inheres in renal system process [Term] id: OBA:1000506 @@ -163969,8 +263324,8 @@ def: "The quality of a lymphatic part of lymphoid system." [AUTO:patterns/patter synonym: "quality of lymphatic part of lymphoid system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006558 ! lymphatic part of lymphoid system -relationship: inheres_in UBERON:0006558 ! lymphatic part of lymphoid system +intersection_of: RO:0000052 UBERON:0006558 ! inheres in lymphatic part of lymphoid system +relationship: RO:0000052 UBERON:0006558 ! inheres in lymphatic part of lymphoid system [Term] id: OBA:1000507 @@ -163979,8 +263334,8 @@ def: "The quality of a facial artery." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of facial artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001612 ! facial artery -relationship: inheres_in UBERON:0001612 ! facial artery +intersection_of: RO:0000052 UBERON:0001612 ! inheres in facial artery +relationship: RO:0000052 UBERON:0001612 ! inheres in facial artery [Term] id: OBA:1000508 @@ -163989,8 +263344,8 @@ def: "The quality of a tarsal bone." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tarsal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001447 ! tarsal bone -relationship: inheres_in UBERON:0001447 ! tarsal bone +intersection_of: RO:0000052 UBERON:0001447 ! inheres in tarsal bone +relationship: RO:0000052 UBERON:0001447 ! inheres in tarsal bone [Term] id: OBA:1000509 @@ -163999,8 +263354,8 @@ def: "The quality of a vasculature of retina." [AUTO:patterns/patterns/entity_at synonym: "quality of vasculature of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000156 ! vasculature of eye quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004864 ! vasculature of retina -relationship: inheres_in UBERON:0004864 ! vasculature of retina +intersection_of: RO:0000052 UBERON:0004864 ! inheres in vasculature of retina +relationship: RO:0000052 UBERON:0004864 ! inheres in vasculature of retina [Term] id: OBA:1000510 @@ -164009,8 +263364,8 @@ def: "The quality of a middle phalanx of manual digit 2." [AUTO:patterns/pattern synonym: "quality of middle phalanx of manual digit 2" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000382 ! middle phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 -relationship: inheres_in UBERON:0004320 ! middle phalanx of manual digit 2 +intersection_of: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 +relationship: RO:0000052 UBERON:0004320 ! inheres in middle phalanx of manual digit 2 [Term] id: OBA:1000511 @@ -164019,8 +263374,8 @@ def: "The quality of a zygomatic arch." [AUTO:patterns/patterns/entity_attribute synonym: "quality of zygomatic arch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002500 ! zygomatic arch -relationship: inheres_in UBERON:0002500 ! zygomatic arch +intersection_of: RO:0000052 UBERON:0002500 ! inheres in zygomatic arch +relationship: RO:0000052 UBERON:0002500 ! inheres in zygomatic arch [Term] id: OBA:1000512 @@ -164029,8 +263384,8 @@ def: "The quality of a ethmoid sinus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ethmoid sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000172 ! paranasal sinus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002453 ! ethmoid sinus -relationship: inheres_in UBERON:0002453 ! ethmoid sinus +intersection_of: RO:0000052 UBERON:0002453 ! inheres in ethmoid sinus +relationship: RO:0000052 UBERON:0002453 ! inheres in ethmoid sinus [Term] id: OBA:1000513 @@ -164039,8 +263394,8 @@ def: "The quality of a anterior ethmoidal artery." [AUTO:patterns/patterns/entit synonym: "quality of anterior ethmoidal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0012318 ! anterior ethmoidal artery -relationship: inheres_in UBERON:0012318 ! anterior ethmoidal artery +intersection_of: RO:0000052 UBERON:0012318 ! inheres in anterior ethmoidal artery +relationship: RO:0000052 UBERON:0012318 ! inheres in anterior ethmoidal artery [Term] id: OBA:1000514 @@ -164049,8 +263404,8 @@ def: "The quality of a frenulum of tongue." [AUTO:patterns/patterns/entity_attri synonym: "quality of frenulum of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000401 ! mouth mucosa quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006689 ! frenulum of tongue -relationship: inheres_in UBERON:0006689 ! frenulum of tongue +intersection_of: RO:0000052 UBERON:0006689 ! inheres in frenulum of tongue +relationship: RO:0000052 UBERON:0006689 ! inheres in frenulum of tongue [Term] id: OBA:1000515 @@ -164059,8 +263414,8 @@ def: "The quality of a vitamin K metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of vitamin K metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042373 ! vitamin K metabolic process -relationship: inheres_in GO:0042373 ! vitamin K metabolic process +intersection_of: RO:0000052 GO:0042373 ! inheres in vitamin K metabolic process +relationship: RO:0000052 GO:0042373 ! inheres in vitamin K metabolic process [Term] id: OBA:1000516 @@ -164069,8 +263424,8 @@ def: "The quality of a inferior rectus extraocular muscle." [AUTO:patterns/patte synonym: "quality of inferior rectus extraocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006322 ! inferior rectus extraocular muscle -relationship: inheres_in UBERON:0006322 ! inferior rectus extraocular muscle +intersection_of: RO:0000052 UBERON:0006322 ! inheres in inferior rectus extraocular muscle +relationship: RO:0000052 UBERON:0006322 ! inheres in inferior rectus extraocular muscle [Term] id: OBA:1000517 @@ -164079,8 +263434,8 @@ def: "The quality of a coronary sinus." [AUTO:patterns/patterns/entity_attribute synonym: "quality of coronary sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005438 ! coronary sinus -relationship: inheres_in UBERON:0005438 ! coronary sinus +intersection_of: RO:0000052 UBERON:0005438 ! inheres in coronary sinus +relationship: RO:0000052 UBERON:0005438 ! inheres in coronary sinus [Term] id: OBA:1000518 @@ -164089,8 +263444,8 @@ def: "The quality of a pituitary gland." [AUTO:patterns/patterns/entity_attribut synonym: "quality of pituitary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000007 ! pituitary gland -relationship: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland +relationship: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:1000519 @@ -164099,8 +263454,8 @@ def: "The quality of a proline metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of proline metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000194 ! glutamine family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006560 ! proline metabolic process -relationship: inheres_in GO:0006560 ! proline metabolic process +intersection_of: RO:0000052 GO:0006560 ! inheres in proline metabolic process +relationship: RO:0000052 GO:0006560 ! inheres in proline metabolic process [Term] id: OBA:1000520 @@ -164109,8 +263464,8 @@ def: "The quality of a tetrapod parietal bone." [AUTO:patterns/patterns/entity_a synonym: "quality of tetrapod parietal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000210 ! tetrapod parietal bone -relationship: inheres_in UBERON:0000210 ! tetrapod parietal bone +intersection_of: RO:0000052 UBERON:0000210 ! inheres in tetrapod parietal bone +relationship: RO:0000052 UBERON:0000210 ! inheres in tetrapod parietal bone [Term] id: OBA:1000521 @@ -164119,8 +263474,8 @@ def: "The quality of a male reproductive system." [AUTO:patterns/patterns/entity synonym: "quality of male reproductive system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005389 ! reproductive system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000079 ! male reproductive system -relationship: inheres_in UBERON:0000079 ! male reproductive system +intersection_of: RO:0000052 UBERON:0000079 ! inheres in male reproductive system +relationship: RO:0000052 UBERON:0000079 ! inheres in male reproductive system [Term] id: OBA:1000522 @@ -164129,8 +263484,8 @@ def: "The quality of a L-serine metabolic process." [AUTO:patterns/patterns/enti synonym: "quality of L-serine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000220 ! serine family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006563 ! L-serine metabolic process -relationship: inheres_in GO:0006563 ! L-serine metabolic process +intersection_of: RO:0000052 GO:0006563 ! inheres in L-serine metabolic process +relationship: RO:0000052 GO:0006563 ! inheres in L-serine metabolic process [Term] id: OBA:1000523 @@ -164139,8 +263494,8 @@ def: "The quality of a common bile duct." [AUTO:patterns/patterns/entity_attribu synonym: "quality of common bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001174 ! common bile duct -relationship: inheres_in UBERON:0001174 ! common bile duct +intersection_of: RO:0000052 UBERON:0001174 ! inheres in common bile duct +relationship: RO:0000052 UBERON:0001174 ! inheres in common bile duct [Term] id: OBA:1000524 @@ -164149,8 +263504,8 @@ def: "The quality of a vena cava." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of vena cava" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000292 ! vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004087 ! vena cava -relationship: inheres_in UBERON:0004087 ! vena cava +intersection_of: RO:0000052 UBERON:0004087 ! inheres in vena cava +relationship: RO:0000052 UBERON:0004087 ! inheres in vena cava [Term] id: OBA:1000525 @@ -164159,8 +263514,8 @@ def: "The quality of a medulla oblongata." [AUTO:patterns/patterns/entity_attrib synonym: "quality of medulla oblongata" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001896 ! medulla oblongata -relationship: inheres_in UBERON:0001896 ! medulla oblongata +intersection_of: RO:0000052 UBERON:0001896 ! inheres in medulla oblongata +relationship: RO:0000052 UBERON:0001896 ! inheres in medulla oblongata [Term] id: OBA:1000526 @@ -164169,8 +263524,8 @@ def: "The quality of a middle phalanx of manual digit 3." [AUTO:patterns/pattern synonym: "quality of middle phalanx of manual digit 3" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000382 ! middle phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 -relationship: inheres_in UBERON:0004321 ! middle phalanx of manual digit 3 +intersection_of: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 +relationship: RO:0000052 UBERON:0004321 ! inheres in middle phalanx of manual digit 3 [Term] id: OBA:1000527 @@ -164179,8 +263534,8 @@ def: "The quality of a inferior thyroid vein." [AUTO:patterns/patterns/entity_at synonym: "quality of inferior thyroid vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000292 ! vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007156 ! inferior thyroid vein -relationship: inheres_in UBERON:0007156 ! inferior thyroid vein +intersection_of: RO:0000052 UBERON:0007156 ! inheres in inferior thyroid vein +relationship: RO:0000052 UBERON:0007156 ! inheres in inferior thyroid vein [Term] id: OBA:1000528 @@ -164189,8 +263544,8 @@ def: "The quality of a glucose homeostasis." [AUTO:patterns/patterns/entity_attr synonym: "quality of glucose homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042593 ! glucose homeostasis -relationship: inheres_in GO:0042593 ! glucose homeostasis +intersection_of: RO:0000052 GO:0042593 ! inheres in glucose homeostasis +relationship: RO:0000052 GO:0042593 ! inheres in glucose homeostasis [Term] id: OBA:1000529 @@ -164199,8 +263554,8 @@ def: "The quality of a ganglion." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000045 ! ganglion -relationship: inheres_in UBERON:0000045 ! ganglion +intersection_of: RO:0000052 UBERON:0000045 ! inheres in ganglion +relationship: RO:0000052 UBERON:0000045 ! inheres in ganglion [Term] id: OBA:1000530 @@ -164209,8 +263564,8 @@ def: "The quality of a vertebral artery." [AUTO:patterns/patterns/entity_attribu synonym: "quality of vertebral artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001535 ! vertebral artery -relationship: inheres_in UBERON:0001535 ! vertebral artery +intersection_of: RO:0000052 UBERON:0001535 ! inheres in vertebral artery +relationship: RO:0000052 UBERON:0001535 ! inheres in vertebral artery [Term] id: OBA:1000531 @@ -164219,8 +263574,8 @@ def: "The quality of a ganglion of peripheral nervous system." [AUTO:patterns/pa synonym: "quality of ganglion of peripheral nervous system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000529 ! ganglion quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003338 ! ganglion of peripheral nervous system -relationship: inheres_in UBERON:0003338 ! ganglion of peripheral nervous system +intersection_of: RO:0000052 UBERON:0003338 ! inheres in ganglion of peripheral nervous system +relationship: RO:0000052 UBERON:0003338 ! inheres in ganglion of peripheral nervous system [Term] id: OBA:1000532 @@ -164229,8 +263584,8 @@ def: "The quality of a styloglossus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of styloglossus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000286 ! extrinsic muscle of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001573 ! styloglossus -relationship: inheres_in UBERON:0001573 ! styloglossus +intersection_of: RO:0000052 UBERON:0001573 ! inheres in styloglossus +relationship: RO:0000052 UBERON:0001573 ! inheres in styloglossus [Term] id: OBA:1000533 @@ -164239,8 +263594,8 @@ def: "The quality of a labium majora." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of labium majora" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000187 ! genital labium quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004085 ! labium majora -relationship: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora +relationship: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:1000534 @@ -164249,8 +263604,8 @@ def: "The quality of a rib." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002228 ! rib -relationship: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib +relationship: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:1000535 @@ -164259,8 +263614,8 @@ def: "The quality of a sacro-iliac joint." [AUTO:patterns/patterns/entity_attrib synonym: "quality of sacro-iliac joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001365 ! sacro-iliac joint -relationship: inheres_in UBERON:0001365 ! sacro-iliac joint +intersection_of: RO:0000052 UBERON:0001365 ! inheres in sacro-iliac joint +relationship: RO:0000052 UBERON:0001365 ! inheres in sacro-iliac joint [Term] id: OBA:1000536 @@ -164269,8 +263624,8 @@ def: "The quality of a cornea." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015052 ! surface structure trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000964 ! cornea -relationship: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea +relationship: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:1000537 @@ -164279,8 +263634,8 @@ def: "The quality of a occipitofrontalis muscle." [AUTO:patterns/patterns/entity synonym: "quality of occipitofrontalis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010946 ! occipitofrontalis muscle -relationship: inheres_in UBERON:0010946 ! occipitofrontalis muscle +intersection_of: RO:0000052 UBERON:0010946 ! inheres in occipitofrontalis muscle +relationship: RO:0000052 UBERON:0010946 ! inheres in occipitofrontalis muscle [Term] id: OBA:1000538 @@ -164289,8 +263644,8 @@ def: "The quality of a magnesium ion homeostasis." [AUTO:patterns/patterns/entit synonym: "quality of magnesium ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000323 ! divalent inorganic cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0010960 ! magnesium ion homeostasis -relationship: inheres_in GO:0010960 ! magnesium ion homeostasis +intersection_of: RO:0000052 GO:0010960 ! inheres in magnesium ion homeostasis +relationship: RO:0000052 GO:0010960 ! inheres in magnesium ion homeostasis [Term] id: OBA:1000539 @@ -164299,8 +263654,8 @@ def: "The quality of a sexual inhibition." [AUTO:patterns/patterns/entity_attrib synonym: "quality of sexual inhibition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000605 ! sexual inhibition -relationship: inheres_in NBO:0000605 ! sexual inhibition +intersection_of: RO:0000052 NBO:0000605 ! inheres in sexual inhibition +relationship: RO:0000052 NBO:0000605 ! inheres in sexual inhibition [Term] id: OBA:1000540 @@ -164309,8 +263664,8 @@ def: "The quality of a dorsal nasal artery." [AUTO:patterns/patterns/entity_attr synonym: "quality of dorsal nasal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001623 ! dorsal nasal artery -relationship: inheres_in UBERON:0001623 ! dorsal nasal artery +intersection_of: RO:0000052 UBERON:0001623 ! inheres in dorsal nasal artery +relationship: RO:0000052 UBERON:0001623 ! inheres in dorsal nasal artery [Term] id: OBA:1000541 @@ -164319,8 +263674,8 @@ def: "The quality of a lumbar region of vertebral column." [AUTO:patterns/patter synonym: "quality of lumbar region of vertebral column" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006074 ! lumbar region of vertebral column -relationship: inheres_in UBERON:0006074 ! lumbar region of vertebral column +intersection_of: RO:0000052 UBERON:0006074 ! inheres in lumbar region of vertebral column +relationship: RO:0000052 UBERON:0006074 ! inheres in lumbar region of vertebral column [Term] id: OBA:1000542 @@ -164329,8 +263684,8 @@ def: "The quality of a cobalamin metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of cobalamin metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009235 ! cobalamin metabolic process -relationship: inheres_in GO:0009235 ! cobalamin metabolic process +intersection_of: RO:0000052 GO:0009235 ! inheres in cobalamin metabolic process +relationship: RO:0000052 GO:0009235 ! inheres in cobalamin metabolic process [Term] id: OBA:1000543 @@ -164339,8 +263694,8 @@ def: "The quality of a uvular muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of uvular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010235 ! uvular muscle -relationship: inheres_in UBERON:0010235 ! uvular muscle +intersection_of: RO:0000052 UBERON:0010235 ! inheres in uvular muscle +relationship: RO:0000052 UBERON:0010235 ! inheres in uvular muscle [Term] id: OBA:1000544 @@ -164350,8 +263705,8 @@ synonym: "quality of voluntary movement behavior" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000678 ! body part movement quality is_a: OBA:1000727 ! multicellular organismal movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000403 ! voluntary movement behavior -relationship: inheres_in NBO:0000403 ! voluntary movement behavior +intersection_of: RO:0000052 NBO:0000403 ! inheres in voluntary movement behavior +relationship: RO:0000052 NBO:0000403 ! inheres in voluntary movement behavior [Term] id: OBA:1000545 @@ -164360,8 +263715,8 @@ def: "The quality of a ovary." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000992 ! ovary -relationship: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary +relationship: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:1000546 @@ -164370,8 +263725,8 @@ def: "The quality of a endometrium." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of endometrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001295 ! endometrium -relationship: inheres_in UBERON:0001295 ! endometrium +intersection_of: RO:0000052 UBERON:0001295 ! inheres in endometrium +relationship: RO:0000052 UBERON:0001295 ! inheres in endometrium [Term] id: OBA:1000547 @@ -164380,8 +263735,8 @@ def: "The quality of a posterior segment of eyeball." [AUTO:patterns/patterns/en synonym: "quality of posterior segment of eyeball" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001802 ! posterior segment of eyeball -relationship: inheres_in UBERON:0001802 ! posterior segment of eyeball +intersection_of: RO:0000052 UBERON:0001802 ! inheres in posterior segment of eyeball +relationship: RO:0000052 UBERON:0001802 ! inheres in posterior segment of eyeball [Term] id: OBA:1000548 @@ -164390,8 +263745,8 @@ def: "The quality of a abducens nerve." [AUTO:patterns/patterns/entity_attribute synonym: "quality of abducens nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001646 ! abducens nerve -relationship: inheres_in UBERON:0001646 ! abducens nerve +intersection_of: RO:0000052 UBERON:0001646 ! inheres in abducens nerve +relationship: RO:0000052 UBERON:0001646 ! inheres in abducens nerve [Term] id: OBA:1000549 @@ -164400,8 +263755,8 @@ def: "The quality of a strand of axillary hair." [AUTO:patterns/patterns/entity_ synonym: "quality of strand of axillary hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0013699 ! strand of axillary hair -relationship: inheres_in UBERON:0013699 ! strand of axillary hair +intersection_of: RO:0000052 UBERON:0013699 ! inheres in strand of axillary hair +relationship: RO:0000052 UBERON:0013699 ! inheres in strand of axillary hair [Term] id: OBA:1000550 @@ -164410,8 +263765,8 @@ def: "The quality of a vitamin E metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of vitamin E metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015087 ! vitamin metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042360 ! vitamin E metabolic process -relationship: inheres_in GO:0042360 ! vitamin E metabolic process +intersection_of: RO:0000052 GO:0042360 ! inheres in vitamin E metabolic process +relationship: RO:0000052 GO:0042360 ! inheres in vitamin E metabolic process [Term] id: OBA:1000551 @@ -164420,8 +263775,8 @@ def: "The quality of a substantia propria of cornea." [AUTO:patterns/patterns/en synonym: "quality of substantia propria of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea -relationship: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea +relationship: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:1000552 @@ -164430,8 +263785,8 @@ def: "The quality of a diaphysis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of diaphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004769 ! diaphysis -relationship: inheres_in UBERON:0004769 ! diaphysis +intersection_of: RO:0000052 UBERON:0004769 ! inheres in diaphysis +relationship: RO:0000052 UBERON:0004769 ! inheres in diaphysis [Term] id: OBA:1000553 @@ -164440,8 +263795,8 @@ def: "The quality of a protein O-linked fucosylation." [AUTO:patterns/patterns/e synonym: "quality of protein O-linked fucosylation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000494 ! protein O-linked glycosylation quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0036066 ! protein O-linked fucosylation -relationship: inheres_in GO:0036066 ! protein O-linked fucosylation +intersection_of: RO:0000052 GO:0036066 ! inheres in protein O-linked fucosylation +relationship: RO:0000052 GO:0036066 ! inheres in protein O-linked fucosylation [Term] id: OBA:1000554 @@ -164450,8 +263805,8 @@ def: "The quality of a systemic arterial system." [AUTO:patterns/patterns/entity synonym: "quality of systemic arterial system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004571 ! systemic arterial system -relationship: inheres_in UBERON:0004571 ! systemic arterial system +intersection_of: RO:0000052 UBERON:0004571 ! inheres in systemic arterial system +relationship: RO:0000052 UBERON:0004571 ! inheres in systemic arterial system [Term] id: OBA:1000555 @@ -164460,8 +263815,8 @@ def: "The quality of a middle phalanx of manual digit 5." [AUTO:patterns/pattern synonym: "quality of middle phalanx of manual digit 5" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000382 ! middle phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 -relationship: inheres_in UBERON:0004323 ! middle phalanx of manual digit 5 +intersection_of: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 +relationship: RO:0000052 UBERON:0004323 ! inheres in middle phalanx of manual digit 5 [Term] id: OBA:1000556 @@ -164470,8 +263825,8 @@ def: "The quality of a dorsum of nose." [AUTO:patterns/patterns/entity_attribute synonym: "quality of dorsum of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0016464 ! dorsum of nose -relationship: inheres_in UBERON:0016464 ! dorsum of nose +intersection_of: RO:0000052 UBERON:0016464 ! inheres in dorsum of nose +relationship: RO:0000052 UBERON:0016464 ! inheres in dorsum of nose [Term] id: OBA:1000557 @@ -164480,8 +263835,8 @@ def: "The quality of a lingual artery." [AUTO:patterns/patterns/entity_attribute synonym: "quality of lingual artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001610 ! lingual artery -relationship: inheres_in UBERON:0001610 ! lingual artery +intersection_of: RO:0000052 UBERON:0001610 ! inheres in lingual artery +relationship: RO:0000052 UBERON:0001610 ! inheres in lingual artery [Term] id: OBA:1000558 @@ -164490,8 +263845,8 @@ def: "The quality of a myelination in peripheral nervous system." [AUTO:patterns synonym: "quality of myelination in peripheral nervous system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000920 ! myelination trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0022011 ! myelination in peripheral nervous system -relationship: inheres_in GO:0022011 ! myelination in peripheral nervous system +intersection_of: RO:0000052 GO:0022011 ! inheres in myelination in peripheral nervous system +relationship: RO:0000052 GO:0022011 ! inheres in myelination in peripheral nervous system [Term] id: OBA:1000559 @@ -164500,8 +263855,8 @@ def: "The quality of a natural killer cell." [AUTO:patterns/patterns/entity_attr synonym: "quality of natural killer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000623 ! natural killer cell -relationship: inheres_in CL:0000623 ! natural killer cell +intersection_of: RO:0000052 CL:0000623 ! inheres in natural killer cell +relationship: RO:0000052 CL:0000623 ! inheres in natural killer cell [Term] id: OBA:1000560 @@ -164510,8 +263865,8 @@ def: "The quality of a proximal epiphysis of fibula." [AUTO:patterns/patterns/en synonym: "quality of proximal epiphysis of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000331 ! epiphysis of fibula quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008775 ! proximal epiphysis of fibula -relationship: inheres_in UBERON:0008775 ! proximal epiphysis of fibula +intersection_of: RO:0000052 UBERON:0008775 ! inheres in proximal epiphysis of fibula +relationship: RO:0000052 UBERON:0008775 ! inheres in proximal epiphysis of fibula [Term] id: OBA:1000561 @@ -164520,8 +263875,8 @@ def: "The quality of a abdominal wall." [AUTO:patterns/patterns/entity_attribute synonym: "quality of abdominal wall" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003697 ! abdominal wall -relationship: inheres_in UBERON:0003697 ! abdominal wall +intersection_of: RO:0000052 UBERON:0003697 ! inheres in abdominal wall +relationship: RO:0000052 UBERON:0003697 ! inheres in abdominal wall [Term] id: OBA:1000562 @@ -164530,8 +263885,8 @@ def: "The quality of a glabella region of bone." [AUTO:patterns/patterns/entity_ synonym: "quality of glabella region of bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0016440 ! glabella region of bone -relationship: inheres_in UBERON:0016440 ! glabella region of bone +intersection_of: RO:0000052 UBERON:0016440 ! inheres in glabella region of bone +relationship: RO:0000052 UBERON:0016440 ! inheres in glabella region of bone [Term] id: OBA:1000563 @@ -164540,8 +263895,8 @@ def: "The quality of a cerebral vein." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of cerebral vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000292 ! vein quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001663 ! cerebral vein -relationship: inheres_in UBERON:0001663 ! cerebral vein +intersection_of: RO:0000052 UBERON:0001663 ! inheres in cerebral vein +relationship: RO:0000052 UBERON:0001663 ! inheres in cerebral vein [Term] id: OBA:1000564 @@ -164551,8 +263906,8 @@ synonym: "quality of microglial cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000236 ! glial cell quality is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000129 ! microglial cell -relationship: inheres_in CL:0000129 ! microglial cell +intersection_of: RO:0000052 CL:0000129 ! inheres in microglial cell +relationship: RO:0000052 CL:0000129 ! inheres in microglial cell [Term] id: OBA:1000565 @@ -164561,8 +263916,8 @@ def: "The quality of a genioglossus muscle." [AUTO:patterns/patterns/entity_attr synonym: "quality of genioglossus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000286 ! extrinsic muscle of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001571 ! genioglossus muscle -relationship: inheres_in UBERON:0001571 ! genioglossus muscle +intersection_of: RO:0000052 UBERON:0001571 ! inheres in genioglossus muscle +relationship: RO:0000052 UBERON:0001571 ! inheres in genioglossus muscle [Term] id: OBA:1000566 @@ -164571,8 +263926,8 @@ def: "The quality of a periorbital region." [AUTO:patterns/patterns/entity_attri synonym: "quality of periorbital region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004090 ! periorbital region -relationship: inheres_in UBERON:0004090 ! periorbital region +intersection_of: RO:0000052 UBERON:0004090 ! inheres in periorbital region +relationship: RO:0000052 UBERON:0004090 ! inheres in periorbital region [Term] id: OBA:1000567 @@ -164581,8 +263936,8 @@ def: "The quality of a accessory XI nerve." [AUTO:patterns/patterns/entity_attri synonym: "quality of accessory XI nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002019 ! accessory XI nerve -relationship: inheres_in UBERON:0002019 ! accessory XI nerve +intersection_of: RO:0000052 UBERON:0002019 ! inheres in accessory XI nerve +relationship: RO:0000052 UBERON:0002019 ! inheres in accessory XI nerve [Term] id: OBA:1000568 @@ -164591,8 +263946,8 @@ def: "The quality of a distal epiphysis of humerus." [AUTO:patterns/patterns/ent synonym: "quality of distal epiphysis of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004404 ! distal epiphysis of humerus -relationship: inheres_in UBERON:0004404 ! distal epiphysis of humerus +intersection_of: RO:0000052 UBERON:0004404 ! inheres in distal epiphysis of humerus +relationship: RO:0000052 UBERON:0004404 ! inheres in distal epiphysis of humerus [Term] id: OBA:1000569 @@ -164601,8 +263956,8 @@ def: "The quality of a mylohyoid muscle." [AUTO:patterns/patterns/entity_attribu synonym: "quality of mylohyoid muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001564 ! mylohyoid muscle -relationship: inheres_in UBERON:0001564 ! mylohyoid muscle +intersection_of: RO:0000052 UBERON:0001564 ! inheres in mylohyoid muscle +relationship: RO:0000052 UBERON:0001564 ! inheres in mylohyoid muscle [Term] id: OBA:1000570 @@ -164611,8 +263966,8 @@ def: "The quality of a hypopharynx." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hypopharynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001051 ! hypopharynx -relationship: inheres_in UBERON:0001051 ! hypopharynx +intersection_of: RO:0000052 UBERON:0001051 ! inheres in hypopharynx +relationship: RO:0000052 UBERON:0001051 ! inheres in hypopharynx [Term] id: OBA:1000571 @@ -164622,8 +263977,8 @@ synonym: "quality of distal phalanx of pedal digit 1" EXACT [AUTO:patterns/patte is_a: OBA:1000161 ! pedal digit 1 phalanx quality is_a: OBA:1000628 ! distal phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 -relationship: inheres_in UBERON:0004315 ! distal phalanx of pedal digit 1 +intersection_of: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 +relationship: RO:0000052 UBERON:0004315 ! inheres in distal phalanx of pedal digit 1 [Term] id: OBA:1000572 @@ -164632,8 +263987,8 @@ def: "The quality of a fibula." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001446 ! fibula -relationship: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula +relationship: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:1000573 @@ -164642,8 +263997,8 @@ def: "The quality of a phosphate ion homeostasis." [AUTO:patterns/patterns/entit synonym: "quality of phosphate ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001765 ! ion homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055062 ! phosphate ion homeostasis -relationship: inheres_in GO:0055062 ! phosphate ion homeostasis +intersection_of: RO:0000052 GO:0055062 ! inheres in phosphate ion homeostasis +relationship: RO:0000052 GO:0055062 ! inheres in phosphate ion homeostasis [Term] id: OBA:1000574 @@ -164652,8 +264007,8 @@ def: "The quality of a B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000236 ! B cell -relationship: inheres_in CL:0000236 ! B cell +intersection_of: RO:0000052 CL:0000236 ! inheres in B cell +relationship: RO:0000052 CL:0000236 ! inheres in B cell [Term] id: OBA:1000575 @@ -164662,8 +264017,8 @@ def: "The quality of a pedal digit 4 phalanx." [AUTO:patterns/patterns/entity_at synonym: "quality of pedal digit 4 phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003862 ! pedal digit 4 phalanx -relationship: inheres_in UBERON:0003862 ! pedal digit 4 phalanx +intersection_of: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx +relationship: RO:0000052 UBERON:0003862 ! inheres in pedal digit 4 phalanx [Term] id: OBA:1000576 @@ -164672,8 +264027,8 @@ def: "The quality of a unsaturated fatty acid metabolic process." [AUTO:patterns synonym: "quality of unsaturated fatty acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000155 ! fatty acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033559 ! unsaturated fatty acid metabolic process -relationship: inheres_in GO:0033559 ! unsaturated fatty acid metabolic process +intersection_of: RO:0000052 GO:0033559 ! inheres in unsaturated fatty acid metabolic process +relationship: RO:0000052 GO:0033559 ! inheres in unsaturated fatty acid metabolic process [Term] id: OBA:1000577 @@ -164682,8 +264037,8 @@ def: "The quality of a digit." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002544 ! digit -relationship: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit +relationship: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:1000578 @@ -164692,8 +264047,8 @@ def: "The quality of a incisor tooth." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001098 ! incisor tooth -relationship: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth +relationship: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:1000579 @@ -164702,8 +264057,8 @@ def: "The quality of a citrulline metabolic process." [AUTO:patterns/patterns/en synonym: "quality of citrulline metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0000052 ! citrulline metabolic process -relationship: inheres_in GO:0000052 ! citrulline metabolic process +intersection_of: RO:0000052 GO:0000052 ! inheres in citrulline metabolic process +relationship: RO:0000052 GO:0000052 ! inheres in citrulline metabolic process [Term] id: OBA:1000580 @@ -164712,8 +264067,8 @@ def: "The quality of a brachial nerve plexus." [AUTO:patterns/patterns/entity_at synonym: "quality of brachial nerve plexus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000638 ! spinal nerve plexus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001814 ! brachial nerve plexus -relationship: inheres_in UBERON:0001814 ! brachial nerve plexus +intersection_of: RO:0000052 UBERON:0001814 ! inheres in brachial nerve plexus +relationship: RO:0000052 UBERON:0001814 ! inheres in brachial nerve plexus [Term] id: OBA:1000581 @@ -164722,8 +264077,8 @@ def: "The quality of a lacrimal drainage system." [AUTO:patterns/patterns/entity synonym: "quality of lacrimal drainage system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001850 ! lacrimal drainage system -relationship: inheres_in UBERON:0001850 ! lacrimal drainage system +intersection_of: RO:0000052 UBERON:0001850 ! inheres in lacrimal drainage system +relationship: RO:0000052 UBERON:0001850 ! inheres in lacrimal drainage system [Term] id: OBA:1000582 @@ -164732,8 +264087,8 @@ def: "The quality of a carnitine metabolic process." [AUTO:patterns/patterns/ent synonym: "quality of carnitine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009437 ! carnitine metabolic process -relationship: inheres_in GO:0009437 ! carnitine metabolic process +intersection_of: RO:0000052 GO:0009437 ! inheres in carnitine metabolic process +relationship: RO:0000052 GO:0009437 ! inheres in carnitine metabolic process [Term] id: OBA:1000583 @@ -164742,8 +264097,8 @@ def: "The quality of a carboxylic acid metabolic process." [AUTO:patterns/patter synonym: "quality of carboxylic acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0019752 ! carboxylic acid metabolic process -relationship: inheres_in GO:0019752 ! carboxylic acid metabolic process +intersection_of: RO:0000052 GO:0019752 ! inheres in carboxylic acid metabolic process +relationship: RO:0000052 GO:0019752 ! inheres in carboxylic acid metabolic process [Term] id: OBA:1000584 @@ -164757,8 +264112,8 @@ def: "The quality of a superoxide metabolic process." [AUTO:patterns/patterns/en synonym: "quality of superoxide metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006801 ! superoxide metabolic process -relationship: inheres_in GO:0006801 ! superoxide metabolic process +intersection_of: RO:0000052 GO:0006801 ! inheres in superoxide metabolic process +relationship: RO:0000052 GO:0006801 ! inheres in superoxide metabolic process [Term] id: OBA:1000586 @@ -164767,8 +264122,8 @@ def: "The quality of a cricoid cartilage." [AUTO:patterns/patterns/entity_attrib synonym: "quality of cricoid cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002375 ! cricoid cartilage -relationship: inheres_in UBERON:0002375 ! cricoid cartilage +intersection_of: RO:0000052 UBERON:0002375 ! inheres in cricoid cartilage +relationship: RO:0000052 UBERON:0002375 ! inheres in cricoid cartilage [Term] id: OBA:1000587 @@ -164777,8 +264132,8 @@ def: "The quality of a renal collecting system." [AUTO:patterns/patterns/entity_ synonym: "quality of renal collecting system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004100 ! renal collecting system -relationship: inheres_in UBERON:0004100 ! renal collecting system +intersection_of: RO:0000052 UBERON:0004100 ! inheres in renal collecting system +relationship: RO:0000052 UBERON:0004100 ! inheres in renal collecting system [Term] id: OBA:1000588 @@ -164787,8 +264142,8 @@ def: "The quality of a laughing behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of laughing behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000617 ! laughing behavior -relationship: inheres_in NBO:0000617 ! laughing behavior +intersection_of: RO:0000052 NBO:0000617 ! inheres in laughing behavior +relationship: RO:0000052 NBO:0000617 ! inheres in laughing behavior [Term] id: OBA:1000589 @@ -164797,8 +264152,8 @@ def: "The quality of a creatine metabolic process." [AUTO:patterns/patterns/enti synonym: "quality of creatine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000604 ! monocarboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006600 ! creatine metabolic process -relationship: inheres_in GO:0006600 ! creatine metabolic process +intersection_of: RO:0000052 GO:0006600 ! inheres in creatine metabolic process +relationship: RO:0000052 GO:0006600 ! inheres in creatine metabolic process [Term] id: OBA:1000590 @@ -164807,8 +264162,8 @@ def: "The quality of a epiphysis of first metatarsal bone." [AUTO:patterns/patte synonym: "quality of epiphysis of first metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000221 ! epiphysis of metatarsal bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone -relationship: inheres_in UBERON:0004395 ! epiphysis of first metatarsal bone +intersection_of: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone +relationship: RO:0000052 UBERON:0004395 ! inheres in epiphysis of first metatarsal bone [Term] id: OBA:1000591 @@ -164817,8 +264172,8 @@ def: "The quality of a radius bone." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of radius bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001423 ! radius bone -relationship: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone +relationship: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:1000592 @@ -164827,8 +264182,8 @@ def: "The quality of a neural spine." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of neural spine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001076 ! neural spine -relationship: inheres_in UBERON:0001076 ! neural spine +intersection_of: RO:0000052 UBERON:0001076 ! inheres in neural spine +relationship: RO:0000052 UBERON:0001076 ! inheres in neural spine [Term] id: OBA:1000593 @@ -164837,8 +264192,8 @@ def: "The quality of a premolar tooth." [AUTO:patterns/patterns/entity_attribute synonym: "quality of premolar tooth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0007120 ! premolar tooth -relationship: inheres_in UBERON:0007120 ! premolar tooth +intersection_of: RO:0000052 UBERON:0007120 ! inheres in premolar tooth +relationship: RO:0000052 UBERON:0007120 ! inheres in premolar tooth [Term] id: OBA:1000594 @@ -164847,8 +264202,8 @@ def: "The quality of a xiphoid process." [AUTO:patterns/patterns/entity_attribut synonym: "quality of xiphoid process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002207 ! xiphoid process -relationship: inheres_in UBERON:0002207 ! xiphoid process +intersection_of: RO:0000052 UBERON:0002207 ! inheres in xiphoid process +relationship: RO:0000052 UBERON:0002207 ! inheres in xiphoid process [Term] id: OBA:1000595 @@ -164857,8 +264212,8 @@ def: "The quality of a proximal epiphysis of ulna." [AUTO:patterns/patterns/enti synonym: "quality of proximal epiphysis of ulna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006822 ! proximal epiphysis of ulna -relationship: inheres_in UBERON:0006822 ! proximal epiphysis of ulna +intersection_of: RO:0000052 UBERON:0006822 ! inheres in proximal epiphysis of ulna +relationship: RO:0000052 UBERON:0006822 ! inheres in proximal epiphysis of ulna [Term] id: OBA:1000596 @@ -164867,8 +264222,8 @@ def: "The quality of a aspartate family amino acid metabolic process." [AUTO:pat synonym: "quality of aspartate family amino acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000232 ! cellular amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009066 ! aspartate family amino acid metabolic process -relationship: inheres_in GO:0009066 ! aspartate family amino acid metabolic process +intersection_of: RO:0000052 GO:0009066 ! inheres in aspartate family amino acid metabolic process +relationship: RO:0000052 GO:0009066 ! inheres in aspartate family amino acid metabolic process [Term] id: OBA:1000597 @@ -164877,8 +264232,8 @@ def: "The quality of a metatarsal bone of digit 1." [AUTO:patterns/patterns/enti synonym: "quality of metatarsal bone of digit 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 -relationship: inheres_in UBERON:0003650 ! metatarsal bone of digit 1 +intersection_of: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 +relationship: RO:0000052 UBERON:0003650 ! inheres in metatarsal bone of digit 1 [Term] id: OBA:1000598 @@ -164887,8 +264242,8 @@ def: "The quality of a costochondral joint." [AUTO:patterns/patterns/entity_attr synonym: "quality of costochondral joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000695 ! synchondrosis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002293 ! costochondral joint -relationship: inheres_in UBERON:0002293 ! costochondral joint +intersection_of: RO:0000052 UBERON:0002293 ! inheres in costochondral joint +relationship: RO:0000052 UBERON:0002293 ! inheres in costochondral joint [Term] id: OBA:1000599 @@ -164897,8 +264252,8 @@ def: "The quality of a spinocerebellar tract." [AUTO:patterns/patterns/entity_at synonym: "quality of spinocerebellar tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005413 ! spinocerebellar tract -relationship: inheres_in UBERON:0005413 ! spinocerebellar tract +intersection_of: RO:0000052 UBERON:0005413 ! inheres in spinocerebellar tract +relationship: RO:0000052 UBERON:0005413 ! inheres in spinocerebellar tract [Term] id: OBA:1000600 @@ -164907,8 +264262,8 @@ def: "The quality of a distal epiphysis of radius." [AUTO:patterns/patterns/enti synonym: "quality of distal epiphysis of radius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004407 ! distal epiphysis of radius -relationship: inheres_in UBERON:0004407 ! distal epiphysis of radius +intersection_of: RO:0000052 UBERON:0004407 ! inheres in distal epiphysis of radius +relationship: RO:0000052 UBERON:0004407 ! inheres in distal epiphysis of radius [Term] id: OBA:1000601 @@ -164917,8 +264272,8 @@ def: "The quality of a medial pterygoid muscle." [AUTO:patterns/patterns/entity_ synonym: "quality of medial pterygoid muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000322 ! masticatory muscle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006718 ! medial pterygoid muscle -relationship: inheres_in UBERON:0006718 ! medial pterygoid muscle +intersection_of: RO:0000052 UBERON:0006718 ! inheres in medial pterygoid muscle +relationship: RO:0000052 UBERON:0006718 ! inheres in medial pterygoid muscle [Term] id: OBA:1000602 @@ -164927,8 +264282,8 @@ def: "The quality of a neural tube closure." [AUTO:patterns/patterns/entity_attr synonym: "quality of neural tube closure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001843 ! neural tube closure -relationship: inheres_in GO:0001843 ! neural tube closure +intersection_of: RO:0000052 GO:0001843 ! inheres in neural tube closure +relationship: RO:0000052 GO:0001843 ! inheres in neural tube closure [Term] id: OBA:1000603 @@ -164937,8 +264292,8 @@ def: "The quality of a emotional behavior." [AUTO:patterns/patterns/entity_attri synonym: "quality of emotional behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000003 ! emotional behavior -relationship: inheres_in NBO:0000003 ! emotional behavior +intersection_of: RO:0000052 NBO:0000003 ! inheres in emotional behavior +relationship: RO:0000052 NBO:0000003 ! inheres in emotional behavior [Term] id: OBA:1000604 @@ -164947,8 +264302,8 @@ def: "The quality of a monocarboxylic acid metabolic process." [AUTO:patterns/pa synonym: "quality of monocarboxylic acid metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000583 ! carboxylic acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032787 ! monocarboxylic acid metabolic process -relationship: inheres_in GO:0032787 ! monocarboxylic acid metabolic process +intersection_of: RO:0000052 GO:0032787 ! inheres in monocarboxylic acid metabolic process +relationship: RO:0000052 GO:0032787 ! inheres in monocarboxylic acid metabolic process [Term] id: OBA:1000605 @@ -164957,8 +264312,8 @@ def: "The quality of a arachnoid mater." [AUTO:patterns/patterns/entity_attribut synonym: "quality of arachnoid mater" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000435 ! meninx quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002362 ! arachnoid mater -relationship: inheres_in UBERON:0002362 ! arachnoid mater +intersection_of: RO:0000052 UBERON:0002362 ! inheres in arachnoid mater +relationship: RO:0000052 UBERON:0002362 ! inheres in arachnoid mater [Term] id: OBA:1000606 @@ -164967,8 +264322,8 @@ def: "The quality of a late embryo." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of late embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000069 ! embryo trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000323 ! late embryo -relationship: inheres_in UBERON:0000323 ! late embryo +intersection_of: RO:0000052 UBERON:0000323 ! inheres in late embryo +relationship: RO:0000052 UBERON:0000323 ! inheres in late embryo [Term] id: OBA:1000607 @@ -164977,8 +264332,8 @@ def: "The quality of a inferior oblique extraocular muscle." [AUTO:patterns/patt synonym: "quality of inferior oblique extraocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006320 ! inferior oblique extraocular muscle -relationship: inheres_in UBERON:0006320 ! inferior oblique extraocular muscle +intersection_of: RO:0000052 UBERON:0006320 ! inheres in inferior oblique extraocular muscle +relationship: RO:0000052 UBERON:0006320 ! inheres in inferior oblique extraocular muscle [Term] id: OBA:1000608 @@ -164987,8 +264342,8 @@ def: "The quality of a eyeball of camera-type eye." [AUTO:patterns/patterns/enti synonym: "quality of eyeball of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye -relationship: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye +relationship: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:1000609 @@ -164997,8 +264352,8 @@ def: "The quality of a renal absorption." [AUTO:patterns/patterns/entity_attribu synonym: "quality of renal absorption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000505 ! renal system process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070293 ! renal absorption -relationship: inheres_in GO:0070293 ! renal absorption +intersection_of: RO:0000052 GO:0070293 ! inheres in renal absorption +relationship: RO:0000052 GO:0070293 ! inheres in renal absorption [Term] id: OBA:1000610 @@ -165007,8 +264362,8 @@ def: "The quality of a proximal phalanx of manus." [AUTO:patterns/patterns/entit synonym: "quality of proximal phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000632 ! phalanx of manus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002234 ! proximal phalanx of manus -relationship: inheres_in UBERON:0002234 ! proximal phalanx of manus +intersection_of: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus +relationship: RO:0000052 UBERON:0002234 ! inheres in proximal phalanx of manus [Term] id: OBA:1000611 @@ -165017,8 +264372,8 @@ def: "The quality of a metatarsal bone of digit 4." [AUTO:patterns/patterns/enti synonym: "quality of metatarsal bone of digit 4" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003653 ! metatarsal bone of digit 4 -relationship: inheres_in UBERON:0003653 ! metatarsal bone of digit 4 +intersection_of: RO:0000052 UBERON:0003653 ! inheres in metatarsal bone of digit 4 +relationship: RO:0000052 UBERON:0003653 ! inheres in metatarsal bone of digit 4 [Term] id: OBA:1000612 @@ -165027,8 +264382,8 @@ def: "The quality of a voluntary skeletal muscle contraction." [AUTO:patterns/pa synonym: "quality of voluntary skeletal muscle contraction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003010 ! voluntary skeletal muscle contraction -relationship: inheres_in GO:0003010 ! voluntary skeletal muscle contraction +intersection_of: RO:0000052 GO:0003010 ! inheres in voluntary skeletal muscle contraction +relationship: RO:0000052 GO:0003010 ! inheres in voluntary skeletal muscle contraction [Term] id: OBA:1000613 @@ -165037,8 +264392,8 @@ def: "The quality of a cervical nerve plexus." [AUTO:patterns/patterns/entity_at synonym: "quality of cervical nerve plexus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000638 ! spinal nerve plexus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003725 ! cervical nerve plexus -relationship: inheres_in UBERON:0003725 ! cervical nerve plexus +intersection_of: RO:0000052 UBERON:0003725 ! inheres in cervical nerve plexus +relationship: RO:0000052 UBERON:0003725 ! inheres in cervical nerve plexus [Term] id: OBA:1000614 @@ -165047,8 +264402,8 @@ def: "The quality of a abdomen musculature." [AUTO:patterns/patterns/entity_attr synonym: "quality of abdomen musculature" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002343 ! abdomen musculature -relationship: inheres_in UBERON:0002343 ! abdomen musculature +intersection_of: RO:0000052 UBERON:0002343 ! inheres in abdomen musculature +relationship: RO:0000052 UBERON:0002343 ! inheres in abdomen musculature [Term] id: OBA:1000615 @@ -165057,8 +264412,8 @@ def: "The quality of a orbit of skull." [AUTO:patterns/patterns/entity_attribute synonym: "quality of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001697 ! orbit of skull -relationship: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull +relationship: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:1000616 @@ -165067,8 +264422,8 @@ def: "The quality of a alanine metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of alanine metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000338 ! pyruvate family amino acid metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006522 ! alanine metabolic process -relationship: inheres_in GO:0006522 ! alanine metabolic process +intersection_of: RO:0000052 GO:0006522 ! inheres in alanine metabolic process +relationship: RO:0000052 GO:0006522 ! inheres in alanine metabolic process [Term] id: OBA:1000617 @@ -165077,8 +264432,8 @@ def: "The quality of a hematopoietic system." [AUTO:patterns/patterns/entity_att synonym: "quality of hematopoietic system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002390 ! hematopoietic system -relationship: inheres_in UBERON:0002390 ! hematopoietic system +intersection_of: RO:0000052 UBERON:0002390 ! inheres in hematopoietic system +relationship: RO:0000052 UBERON:0002390 ! inheres in hematopoietic system [Term] id: OBA:1000618 @@ -165087,8 +264442,8 @@ def: "The quality of a occipital bone." [AUTO:patterns/patterns/entity_attribute synonym: "quality of occipital bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001676 ! occipital bone -relationship: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone +relationship: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:1000619 @@ -165097,8 +264452,8 @@ def: "The quality of a protein N-linked glycosylation." [AUTO:patterns/patterns/ synonym: "quality of protein N-linked glycosylation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000264 ! protein glycosylation quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006487 ! protein N-linked glycosylation -relationship: inheres_in GO:0006487 ! protein N-linked glycosylation +intersection_of: RO:0000052 GO:0006487 ! inheres in protein N-linked glycosylation +relationship: RO:0000052 GO:0006487 ! inheres in protein N-linked glycosylation [Term] id: OBA:1000620 @@ -165107,8 +264462,8 @@ def: "The quality of a placenta." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of placenta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001987 ! placenta -relationship: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta +relationship: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:1000621 @@ -165117,8 +264472,8 @@ def: "The quality of a femur." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000981 ! femur -relationship: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur +relationship: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:1000622 @@ -165127,8 +264482,8 @@ def: "The quality of a lacrimal artery." [AUTO:patterns/patterns/entity_attribut synonym: "quality of lacrimal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001622 ! lacrimal artery -relationship: inheres_in UBERON:0001622 ! lacrimal artery +intersection_of: RO:0000052 UBERON:0001622 ! inheres in lacrimal artery +relationship: RO:0000052 UBERON:0001622 ! inheres in lacrimal artery [Term] id: OBA:1000623 @@ -165137,8 +264492,8 @@ def: "The quality of a thoracic cavity." [AUTO:patterns/patterns/entity_attribut synonym: "quality of thoracic cavity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002224 ! thoracic cavity -relationship: inheres_in UBERON:0002224 ! thoracic cavity +intersection_of: RO:0000052 UBERON:0002224 ! inheres in thoracic cavity +relationship: RO:0000052 UBERON:0002224 ! inheres in thoracic cavity [Term] id: OBA:1000624 @@ -165147,8 +264502,8 @@ def: "The quality of a sperm ejaculation." [AUTO:patterns/patterns/entity_attrib synonym: "quality of sperm ejaculation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042713 ! sperm ejaculation -relationship: inheres_in GO:0042713 ! sperm ejaculation +intersection_of: RO:0000052 GO:0042713 ! inheres in sperm ejaculation +relationship: RO:0000052 GO:0042713 ! inheres in sperm ejaculation [Term] id: OBA:1000625 @@ -165157,8 +264512,8 @@ def: "The quality of a abdomen." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of abdomen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000916 ! abdomen -relationship: inheres_in UBERON:0000916 ! abdomen +intersection_of: RO:0000052 UBERON:0000916 ! inheres in abdomen +relationship: RO:0000052 UBERON:0000916 ! inheres in abdomen [Term] id: OBA:1000626 @@ -165167,8 +264522,8 @@ def: "The quality of a umbilical cord." [AUTO:patterns/patterns/entity_attribute synonym: "quality of umbilical cord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002331 ! umbilical cord -relationship: inheres_in UBERON:0002331 ! umbilical cord +intersection_of: RO:0000052 UBERON:0002331 ! inheres in umbilical cord +relationship: RO:0000052 UBERON:0002331 ! inheres in umbilical cord [Term] id: OBA:1000627 @@ -165177,8 +264532,8 @@ def: "The quality of a ocular angle artery." [AUTO:patterns/patterns/entity_attr synonym: "quality of ocular angle artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010408 ! ocular angle artery -relationship: inheres_in UBERON:0010408 ! ocular angle artery +intersection_of: RO:0000052 UBERON:0010408 ! inheres in ocular angle artery +relationship: RO:0000052 UBERON:0010408 ! inheres in ocular angle artery [Term] id: OBA:1000628 @@ -165187,8 +264542,8 @@ def: "The quality of a distal phalanx of pes." [AUTO:patterns/patterns/entity_at synonym: "quality of distal phalanx of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000501 ! phalanx of pes quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003867 ! distal phalanx of pes -relationship: inheres_in UBERON:0003867 ! distal phalanx of pes +intersection_of: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes +relationship: RO:0000052 UBERON:0003867 ! inheres in distal phalanx of pes [Term] id: OBA:1000629 @@ -165197,8 +264552,8 @@ def: "The quality of a hypothalamus-pituitary axis." [AUTO:patterns/patterns/ent synonym: "quality of hypothalamus-pituitary axis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004092 ! hypothalamus-pituitary axis -relationship: inheres_in UBERON:0004092 ! hypothalamus-pituitary axis +intersection_of: RO:0000052 UBERON:0004092 ! inheres in hypothalamus-pituitary axis +relationship: RO:0000052 UBERON:0004092 ! inheres in hypothalamus-pituitary axis [Term] id: OBA:1000630 @@ -165207,8 +264562,8 @@ def: "The quality of a cation homeostasis." [AUTO:patterns/patterns/entity_attri synonym: "quality of cation homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001765 ! ion homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055080 ! cation homeostasis -relationship: inheres_in GO:0055080 ! cation homeostasis +intersection_of: RO:0000052 GO:0055080 ! inheres in cation homeostasis +relationship: RO:0000052 GO:0055080 ! inheres in cation homeostasis [Term] id: OBA:1000631 @@ -165217,8 +264572,8 @@ def: "The quality of a maxillary sinus." [AUTO:patterns/patterns/entity_attribut synonym: "quality of maxillary sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000172 ! paranasal sinus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001764 ! maxillary sinus -relationship: inheres_in UBERON:0001764 ! maxillary sinus +intersection_of: RO:0000052 UBERON:0001764 ! inheres in maxillary sinus +relationship: RO:0000052 UBERON:0001764 ! inheres in maxillary sinus [Term] id: OBA:1000632 @@ -165227,8 +264582,8 @@ def: "The quality of a phalanx of manus." [AUTO:patterns/patterns/entity_attribu synonym: "quality of phalanx of manus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001436 ! phalanx of manus -relationship: inheres_in UBERON:0001436 ! phalanx of manus +intersection_of: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus +relationship: RO:0000052 UBERON:0001436 ! inheres in phalanx of manus [Term] id: OBA:1000633 @@ -165237,8 +264592,8 @@ def: "The quality of a heme biosynthetic process." [AUTO:patterns/patterns/entit synonym: "quality of heme biosynthetic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006783 ! heme biosynthetic process -relationship: inheres_in GO:0006783 ! heme biosynthetic process +intersection_of: RO:0000052 GO:0006783 ! inheres in heme biosynthetic process +relationship: RO:0000052 GO:0006783 ! inheres in heme biosynthetic process [Term] id: OBA:1000634 @@ -165247,8 +264602,8 @@ def: "The quality of a lung lobe formation." [AUTO:patterns/patterns/entity_attr synonym: "quality of lung lobe formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060464 ! lung lobe formation -relationship: inheres_in GO:0060464 ! lung lobe formation +intersection_of: RO:0000052 GO:0060464 ! inheres in lung lobe formation +relationship: RO:0000052 GO:0060464 ! inheres in lung lobe formation [Term] id: OBA:1000635 @@ -165257,8 +264612,8 @@ def: "The quality of a liver." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002107 ! liver -relationship: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver +relationship: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:1000636 @@ -165267,8 +264622,8 @@ def: "The quality of a orbicularis oris muscle." [AUTO:patterns/patterns/entity_ synonym: "quality of orbicularis oris muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010933 ! orbicularis oris muscle -relationship: inheres_in UBERON:0010933 ! orbicularis oris muscle +intersection_of: RO:0000052 UBERON:0010933 ! inheres in orbicularis oris muscle +relationship: RO:0000052 UBERON:0010933 ! inheres in orbicularis oris muscle [Term] id: OBA:1000637 @@ -165277,8 +264632,8 @@ def: "The quality of a levator palpebrae superioris." [AUTO:patterns/patterns/en synonym: "quality of levator palpebrae superioris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001604 ! levator palpebrae superioris -relationship: inheres_in UBERON:0001604 ! levator palpebrae superioris +intersection_of: RO:0000052 UBERON:0001604 ! inheres in levator palpebrae superioris +relationship: RO:0000052 UBERON:0001604 ! inheres in levator palpebrae superioris [Term] id: OBA:1000638 @@ -165287,8 +264642,8 @@ def: "The quality of a spinal nerve plexus." [AUTO:patterns/patterns/entity_attr synonym: "quality of spinal nerve plexus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001813 ! spinal nerve plexus -relationship: inheres_in UBERON:0001813 ! spinal nerve plexus +intersection_of: RO:0000052 UBERON:0001813 ! inheres in spinal nerve plexus +relationship: RO:0000052 UBERON:0001813 ! inheres in spinal nerve plexus [Term] id: OBA:1000639 @@ -165297,8 +264652,8 @@ def: "The quality of a interventricular septum." [AUTO:patterns/patterns/entity_ synonym: "quality of interventricular septum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000251 ! cardiac septum quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002094 ! interventricular septum -relationship: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum +relationship: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:1000640 @@ -165307,8 +264662,8 @@ def: "The quality of a dorsal thalamus." [AUTO:patterns/patterns/entity_attribut synonym: "quality of dorsal thalamus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004703 ! dorsal thalamus -relationship: inheres_in UBERON:0004703 ! dorsal thalamus +intersection_of: RO:0000052 UBERON:0004703 ! inheres in dorsal thalamus +relationship: RO:0000052 UBERON:0004703 ! inheres in dorsal thalamus [Term] id: OBA:1000641 @@ -165317,8 +264672,8 @@ def: "The quality of a blood coagulation, common pathway." [AUTO:patterns/patter synonym: "quality of blood coagulation, common pathway" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072377 ! blood coagulation, common pathway -relationship: inheres_in GO:0072377 ! blood coagulation, common pathway +intersection_of: RO:0000052 GO:0072377 ! inheres in blood coagulation, common pathway +relationship: RO:0000052 GO:0072377 ! inheres in blood coagulation, common pathway [Term] id: OBA:1000642 @@ -165327,8 +264682,8 @@ def: "The quality of a intestinal absorption." [AUTO:patterns/patterns/entity_at synonym: "quality of intestinal absorption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050892 ! intestinal absorption -relationship: inheres_in GO:0050892 ! intestinal absorption +intersection_of: RO:0000052 GO:0050892 ! inheres in intestinal absorption +relationship: RO:0000052 GO:0050892 ! inheres in intestinal absorption [Term] id: OBA:1000643 @@ -165337,8 +264692,8 @@ def: "The quality of a cementum." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of cementum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000260 ! odontoid tissue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001753 ! cementum -relationship: inheres_in UBERON:0001753 ! cementum +intersection_of: RO:0000052 UBERON:0001753 ! inheres in cementum +relationship: RO:0000052 UBERON:0001753 ! inheres in cementum [Term] id: OBA:1000644 @@ -165347,8 +264702,8 @@ def: "The quality of a gluteal muscle." [AUTO:patterns/patterns/entity_attribute synonym: "quality of gluteal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002000 ! gluteal muscle -relationship: inheres_in UBERON:0002000 ! gluteal muscle +intersection_of: RO:0000052 UBERON:0002000 ! inheres in gluteal muscle +relationship: RO:0000052 UBERON:0002000 ! inheres in gluteal muscle [Term] id: OBA:1000645 @@ -165357,8 +264712,8 @@ def: "The quality of a depressor anguli oris muscle." [AUTO:patterns/patterns/en synonym: "quality of depressor anguli oris muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0008597 ! depressor anguli oris muscle -relationship: inheres_in UBERON:0008597 ! depressor anguli oris muscle +intersection_of: RO:0000052 UBERON:0008597 ! inheres in depressor anguli oris muscle +relationship: RO:0000052 UBERON:0008597 ! inheres in depressor anguli oris muscle [Term] id: OBA:1000646 @@ -165367,8 +264722,8 @@ def: "The quality of a cervical vertebra 1 anterior tubercle." [AUTO:patterns/pa synonym: "quality of cervical vertebra 1 anterior tubercle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005810 ! cervical vertebra 1 anterior tubercle -relationship: inheres_in UBERON:0005810 ! cervical vertebra 1 anterior tubercle +intersection_of: RO:0000052 UBERON:0005810 ! inheres in cervical vertebra 1 anterior tubercle +relationship: RO:0000052 UBERON:0005810 ! inheres in cervical vertebra 1 anterior tubercle [Term] id: OBA:1000647 @@ -165377,8 +264732,8 @@ def: "The quality of a associative learning behavior." [AUTO:patterns/patterns/e synonym: "quality of associative learning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000171 ! associative learning behavior -relationship: inheres_in NBO:0000171 ! associative learning behavior +intersection_of: RO:0000052 NBO:0000171 ! inheres in associative learning behavior +relationship: RO:0000052 NBO:0000171 ! inheres in associative learning behavior [Term] id: OBA:1000648 @@ -165387,8 +264742,8 @@ def: "The quality of a chemical nociceptive behavior." [AUTO:patterns/patterns/e synonym: "quality of chemical nociceptive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000746 ! nociceptive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000333 ! chemical nociceptive behavior -relationship: inheres_in NBO:0000333 ! chemical nociceptive behavior +intersection_of: RO:0000052 NBO:0000333 ! inheres in chemical nociceptive behavior +relationship: RO:0000052 NBO:0000333 ! inheres in chemical nociceptive behavior [Term] id: OBA:1000649 @@ -165397,8 +264752,8 @@ def: "The quality of a anagen." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of anagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042640 ! anagen -relationship: inheres_in GO:0042640 ! anagen +intersection_of: RO:0000052 GO:0042640 ! inheres in anagen +relationship: RO:0000052 GO:0042640 ! inheres in anagen [Term] id: OBA:1000650 @@ -165407,8 +264762,8 @@ def: "The quality of a catalase activity." [AUTO:patterns/patterns/entity_attrib synonym: "quality of catalase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000714 ! peroxidase activity quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004096 ! catalase activity -relationship: inheres_in GO:0004096 ! catalase activity +intersection_of: RO:0000052 GO:0004096 ! inheres in catalase activity +relationship: RO:0000052 GO:0004096 ! inheres in catalase activity [Term] id: OBA:1000651 @@ -165417,8 +264772,8 @@ def: "The quality of a type IV hypersensitivity." [AUTO:patterns/patterns/entity synonym: "quality of type IV hypersensitivity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010139 ! immune response trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001806 ! type IV hypersensitivity -relationship: inheres_in GO:0001806 ! type IV hypersensitivity +intersection_of: RO:0000052 GO:0001806 ! inheres in type IV hypersensitivity +relationship: RO:0000052 GO:0001806 ! inheres in type IV hypersensitivity [Term] id: OBA:1000652 @@ -165428,8 +264783,8 @@ synonym: "quality of spatial working memory" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000858 ! spatial memory quality is_a: OBA:1000895 ! short-term memory quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000555 ! spatial working memory -relationship: inheres_in NBO:0000555 ! spatial working memory +intersection_of: RO:0000052 NBO:0000555 ! inheres in spatial working memory +relationship: RO:0000052 NBO:0000555 ! inheres in spatial working memory [Term] id: OBA:1000653 @@ -165438,8 +264793,8 @@ def: "The quality of a xiphoid cartilage." [AUTO:patterns/patterns/entity_attrib synonym: "quality of xiphoid cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006430 ! xiphoid cartilage -relationship: inheres_in UBERON:0006430 ! xiphoid cartilage +intersection_of: RO:0000052 UBERON:0006430 ! inheres in xiphoid cartilage +relationship: RO:0000052 UBERON:0006430 ! inheres in xiphoid cartilage [Term] id: OBA:1000654 @@ -165448,8 +264803,8 @@ def: "The quality of a saccharin consumption." [AUTO:patterns/patterns/entity_at synonym: "quality of saccharin consumption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000690 ! food consumption quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000136 ! saccharin consumption -relationship: inheres_in NBO:0000136 ! saccharin consumption +intersection_of: RO:0000052 NBO:0000136 ! inheres in saccharin consumption +relationship: RO:0000052 NBO:0000136 ! inheres in saccharin consumption [Term] id: OBA:1000655 @@ -165458,8 +264813,8 @@ def: "The quality of a ornithine carbamoyltransferase activity." [AUTO:patterns/ synonym: "quality of ornithine carbamoyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity -relationship: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity +intersection_of: RO:0000052 GO:0004585 ! inheres in ornithine carbamoyltransferase activity +relationship: RO:0000052 GO:0004585 ! inheres in ornithine carbamoyltransferase activity [Term] id: OBA:1000656 @@ -165468,8 +264823,8 @@ def: "The quality of a social grooming." [AUTO:patterns/patterns/entity_attribut synonym: "quality of social grooming" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000450 ! social grooming -relationship: inheres_in NBO:0000450 ! social grooming +intersection_of: RO:0000052 NBO:0000450 ! inheres in social grooming +relationship: RO:0000052 NBO:0000450 ! inheres in social grooming [Term] id: OBA:1000657 @@ -165478,8 +264833,8 @@ def: "The quality of a response to novel object." [AUTO:patterns/patterns/entity synonym: "quality of response to novel object" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000891 ! novelty response behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000098 ! response to novel object -relationship: inheres_in NBO:0000098 ! response to novel object +intersection_of: RO:0000052 NBO:0000098 ! inheres in response to novel object +relationship: RO:0000052 NBO:0000098 ! inheres in response to novel object [Term] id: OBA:1000658 @@ -165488,8 +264843,8 @@ def: "The quality of a cholinesterase activity." [AUTO:patterns/patterns/entity_ synonym: "quality of cholinesterase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004104 ! cholinesterase activity -relationship: inheres_in GO:0004104 ! cholinesterase activity +intersection_of: RO:0000052 GO:0004104 ! inheres in cholinesterase activity +relationship: RO:0000052 GO:0004104 ! inheres in cholinesterase activity [Term] id: OBA:1000659 @@ -165498,8 +264853,8 @@ def: "The quality of a molecular layer of cerebellar cortex." [AUTO:patterns/pat synonym: "quality of molecular layer of cerebellar cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002974 ! molecular layer of cerebellar cortex -relationship: inheres_in UBERON:0002974 ! molecular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002974 ! inheres in molecular layer of cerebellar cortex +relationship: RO:0000052 UBERON:0002974 ! inheres in molecular layer of cerebellar cortex [Term] id: OBA:1000660 @@ -165508,8 +264863,8 @@ def: "The quality of a trunk or cervical vertebra." [AUTO:patterns/patterns/enti synonym: "quality of trunk or cervical vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004451 ! trunk or cervical vertebra -relationship: inheres_in UBERON:0004451 ! trunk or cervical vertebra +intersection_of: RO:0000052 UBERON:0004451 ! inheres in trunk or cervical vertebra +relationship: RO:0000052 UBERON:0004451 ! inheres in trunk or cervical vertebra [Term] id: OBA:1000661 @@ -165518,8 +264873,8 @@ def: "The quality of a choroidal blood vessel." [AUTO:patterns/patterns/entity_a synonym: "quality of choroidal blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000301 ! head blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002443 ! choroidal blood vessel -relationship: inheres_in UBERON:0002443 ! choroidal blood vessel +intersection_of: RO:0000052 UBERON:0002443 ! inheres in choroidal blood vessel +relationship: RO:0000052 UBERON:0002443 ! inheres in choroidal blood vessel [Term] id: OBA:1000662 @@ -165528,8 +264883,8 @@ def: "The quality of a tyrosine 3-monooxygenase activity." [AUTO:patterns/patter synonym: "quality of tyrosine 3-monooxygenase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004511 ! tyrosine 3-monooxygenase activity -relationship: inheres_in GO:0004511 ! tyrosine 3-monooxygenase activity +intersection_of: RO:0000052 GO:0004511 ! inheres in tyrosine 3-monooxygenase activity +relationship: RO:0000052 GO:0004511 ! inheres in tyrosine 3-monooxygenase activity [Term] id: OBA:1000663 @@ -165538,8 +264893,8 @@ def: "The quality of a mesangial cell." [AUTO:patterns/patterns/entity_attribute synonym: "quality of mesangial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000650 ! mesangial cell -relationship: inheres_in CL:0000650 ! mesangial cell +intersection_of: RO:0000052 CL:0000650 ! inheres in mesangial cell +relationship: RO:0000052 CL:0000650 ! inheres in mesangial cell [Term] id: OBA:1000664 @@ -165548,8 +264903,8 @@ def: "The quality of a barbering behavior." [AUTO:patterns/patterns/entity_attri synonym: "quality of barbering behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000560 ! barbering behavior -relationship: inheres_in NBO:0000560 ! barbering behavior +intersection_of: RO:0000052 NBO:0000560 ! inheres in barbering behavior +relationship: RO:0000052 NBO:0000560 ! inheres in barbering behavior [Term] id: OBA:1000665 @@ -165558,8 +264913,8 @@ def: "The quality of a strand of auchene hair." [AUTO:patterns/patterns/entity_a synonym: "quality of strand of auchene hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010510 ! strand of auchene hair -relationship: inheres_in UBERON:0010510 ! strand of auchene hair +intersection_of: RO:0000052 UBERON:0010510 ! inheres in strand of auchene hair +relationship: RO:0000052 UBERON:0010510 ! inheres in strand of auchene hair [Term] id: OBA:1000666 @@ -165568,8 +264923,8 @@ def: "The quality of a tongue taste bud." [AUTO:patterns/patterns/entity_attribu synonym: "quality of tongue taste bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0014451 ! tongue taste bud -relationship: inheres_in UBERON:0014451 ! tongue taste bud +intersection_of: RO:0000052 UBERON:0014451 ! inheres in tongue taste bud +relationship: RO:0000052 UBERON:0014451 ! inheres in tongue taste bud [Term] id: OBA:1000667 @@ -165578,8 +264933,8 @@ def: "The quality of a creatine kinase activity." [AUTO:patterns/patterns/entity synonym: "quality of creatine kinase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004111 ! creatine kinase activity -relationship: inheres_in GO:0004111 ! creatine kinase activity +intersection_of: RO:0000052 GO:0004111 ! inheres in creatine kinase activity +relationship: RO:0000052 GO:0004111 ! inheres in creatine kinase activity [Term] id: OBA:1000668 @@ -165589,8 +264944,8 @@ synonym: "quality of behavioral response to light" EXACT [AUTO:patterns/patterns is_a: OBA:1000369 ! behavior process quality is_a: OBA:1000743 ! response to light stimulus quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0001571 ! behavioral response to light -relationship: inheres_in NBO:0001571 ! behavioral response to light +intersection_of: RO:0000052 NBO:0001571 ! inheres in behavioral response to light +relationship: RO:0000052 NBO:0001571 ! inheres in behavioral response to light [Term] id: OBA:1000669 @@ -165599,8 +264954,8 @@ def: "The quality of a branching involved in ureteric bud morphogenesis." [AUTO: synonym: "quality of branching involved in ureteric bud morphogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001658 ! branching involved in ureteric bud morphogenesis -relationship: inheres_in GO:0001658 ! branching involved in ureteric bud morphogenesis +intersection_of: RO:0000052 GO:0001658 ! inheres in branching involved in ureteric bud morphogenesis +relationship: RO:0000052 GO:0001658 ! inheres in branching involved in ureteric bud morphogenesis [Term] id: OBA:1000670 @@ -165609,8 +264964,8 @@ def: "The quality of a intramembranous ossification." [AUTO:patterns/patterns/en synonym: "quality of intramembranous ossification" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000057 ! ossification trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001957 ! intramembranous ossification -relationship: inheres_in GO:0001957 ! intramembranous ossification +intersection_of: RO:0000052 GO:0001957 ! inheres in intramembranous ossification +relationship: RO:0000052 GO:0001957 ! inheres in intramembranous ossification [Term] id: OBA:1000671 @@ -165619,8 +264974,8 @@ def: "The quality of a lymph node secondary follicle." [AUTO:patterns/patterns/e synonym: "quality of lymph node secondary follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010753 ! lymph node secondary follicle -relationship: inheres_in UBERON:0010753 ! lymph node secondary follicle +intersection_of: RO:0000052 UBERON:0010753 ! inheres in lymph node secondary follicle +relationship: RO:0000052 UBERON:0010753 ! inheres in lymph node secondary follicle [Term] id: OBA:1000672 @@ -165629,8 +264984,8 @@ def: "The quality of a melanosome transport." [AUTO:patterns/patterns/entity_att synonym: "quality of melanosome transport" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032402 ! melanosome transport -relationship: inheres_in GO:0032402 ! melanosome transport +intersection_of: RO:0000052 GO:0032402 ! inheres in melanosome transport +relationship: RO:0000052 GO:0032402 ! inheres in melanosome transport [Term] id: OBA:1000673 @@ -165639,8 +264994,8 @@ def: "The quality of a neuromuscular process controlling balance." [AUTO:pattern synonym: "quality of neuromuscular process controlling balance" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050885 ! neuromuscular process controlling balance -relationship: inheres_in GO:0050885 ! neuromuscular process controlling balance +intersection_of: RO:0000052 GO:0050885 ! inheres in neuromuscular process controlling balance +relationship: RO:0000052 GO:0050885 ! inheres in neuromuscular process controlling balance [Term] id: OBA:1000674 @@ -165649,8 +265004,8 @@ def: "The quality of a strand of awl hair." [AUTO:patterns/patterns/entity_attri synonym: "quality of strand of awl hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010511 ! strand of awl hair -relationship: inheres_in UBERON:0010511 ! strand of awl hair +intersection_of: RO:0000052 UBERON:0010511 ! inheres in strand of awl hair +relationship: RO:0000052 UBERON:0010511 ! inheres in strand of awl hair [Term] id: OBA:1000675 @@ -165659,8 +265014,8 @@ def: "The quality of a transverse process of vertebra." [AUTO:patterns/patterns/ synonym: "quality of transverse process of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001077 ! transverse process of vertebra -relationship: inheres_in UBERON:0001077 ! transverse process of vertebra +intersection_of: RO:0000052 UBERON:0001077 ! inheres in transverse process of vertebra +relationship: RO:0000052 UBERON:0001077 ! inheres in transverse process of vertebra [Term] id: OBA:1000676 @@ -165669,8 +265024,8 @@ def: "The quality of a uterine gland development." [AUTO:patterns/patterns/entit synonym: "quality of uterine gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903709 ! uterine gland development -relationship: inheres_in GO:1903709 ! uterine gland development +intersection_of: RO:0000052 GO:1903709 ! inheres in uterine gland development +relationship: RO:0000052 GO:1903709 ! inheres in uterine gland development [Term] id: OBA:1000677 @@ -165679,8 +265034,8 @@ def: "The quality of a bony labyrinth." [AUTO:patterns/patterns/entity_attribute synonym: "quality of bony labyrinth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001839 ! bony labyrinth -relationship: inheres_in UBERON:0001839 ! bony labyrinth +intersection_of: RO:0000052 UBERON:0001839 ! inheres in bony labyrinth +relationship: RO:0000052 UBERON:0001839 ! inheres in bony labyrinth [Term] id: OBA:1000678 @@ -165689,8 +265044,8 @@ def: "The quality of a body part movement." [AUTO:patterns/patterns/entity_attri synonym: "quality of body part movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000001 ! body part movement -relationship: inheres_in NBO:0000001 ! body part movement +intersection_of: RO:0000052 NBO:0000001 ! inheres in body part movement +relationship: RO:0000052 NBO:0000001 ! inheres in body part movement [Term] id: OBA:1000679 @@ -165699,8 +265054,8 @@ def: "The quality of a cocaine consumption." [AUTO:patterns/patterns/entity_attr synonym: "quality of cocaine consumption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0001915 ! cocaine consumption -relationship: inheres_in NBO:0001915 ! cocaine consumption +intersection_of: RO:0000052 NBO:0001915 ! inheres in cocaine consumption +relationship: RO:0000052 NBO:0001915 ! inheres in cocaine consumption [Term] id: OBA:1000680 @@ -165709,8 +265064,8 @@ def: "The quality of a hormone-sensitive lipase activity." [AUTO:patterns/patter synonym: "quality of hormone-sensitive lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033878 ! hormone-sensitive lipase activity -relationship: inheres_in GO:0033878 ! hormone-sensitive lipase activity +intersection_of: RO:0000052 GO:0033878 ! inheres in hormone-sensitive lipase activity +relationship: RO:0000052 GO:0033878 ! inheres in hormone-sensitive lipase activity [Term] id: OBA:1000681 @@ -165719,8 +265074,8 @@ def: "The quality of a head bobbing." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of head bobbing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000726 ! head movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000570 ! head bobbing -relationship: inheres_in NBO:0000570 ! head bobbing +intersection_of: RO:0000052 NBO:0000570 ! inheres in head bobbing +relationship: RO:0000052 NBO:0000570 ! inheres in head bobbing [Term] id: OBA:1000682 @@ -165729,8 +265084,8 @@ def: "The quality of a hippocampus granule cell layer." [AUTO:patterns/patterns/ synonym: "quality of hippocampus granule cell layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005367 ! hippocampus granule cell layer -relationship: inheres_in UBERON:0005367 ! hippocampus granule cell layer +intersection_of: RO:0000052 UBERON:0005367 ! inheres in hippocampus granule cell layer +relationship: RO:0000052 UBERON:0005367 ! inheres in hippocampus granule cell layer [Term] id: OBA:1000683 @@ -165739,8 +265094,8 @@ def: "The quality of a development of secondary sexual characteristics." [AUTO:p synonym: "quality of development of secondary sexual characteristics" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045136 ! development of secondary sexual characteristics -relationship: inheres_in GO:0045136 ! development of secondary sexual characteristics +intersection_of: RO:0000052 GO:0045136 ! inheres in development of secondary sexual characteristics +relationship: RO:0000052 GO:0045136 ! inheres in development of secondary sexual characteristics [Term] id: OBA:1000684 @@ -165749,8 +265104,8 @@ def: "The quality of a locomotory behavior." [AUTO:patterns/patterns/entity_attr synonym: "quality of locomotory behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000013 ! locomotory behavior -relationship: inheres_in NBO:0000013 ! locomotory behavior +intersection_of: RO:0000052 NBO:0000013 ! inheres in locomotory behavior +relationship: RO:0000052 NBO:0000013 ! inheres in locomotory behavior [Term] id: OBA:1000685 @@ -165759,8 +265114,8 @@ def: "The quality of a conditioned taste aversion." [AUTO:patterns/patterns/enti synonym: "quality of conditioned taste aversion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000211 ! conditioned taste aversion -relationship: inheres_in NBO:0000211 ! conditioned taste aversion +intersection_of: RO:0000052 NBO:0000211 ! inheres in conditioned taste aversion +relationship: RO:0000052 NBO:0000211 ! inheres in conditioned taste aversion [Term] id: OBA:1000686 @@ -165769,8 +265124,8 @@ def: "The quality of a vitreous body." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of vitreous body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001798 ! vitreous body -relationship: inheres_in UBERON:0001798 ! vitreous body +intersection_of: RO:0000052 UBERON:0001798 ! inheres in vitreous body +relationship: RO:0000052 UBERON:0001798 ! inheres in vitreous body [Term] id: OBA:1000687 @@ -165779,8 +265134,8 @@ def: "The quality of a maternal nurturing behavior." [AUTO:patterns/patterns/ent synonym: "quality of maternal nurturing behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000753 ! maternal behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000152 ! maternal nurturing behavior -relationship: inheres_in NBO:0000152 ! maternal nurturing behavior +intersection_of: RO:0000052 NBO:0000152 ! inheres in maternal nurturing behavior +relationship: RO:0000052 NBO:0000152 ! inheres in maternal nurturing behavior [Term] id: OBA:1000688 @@ -165789,8 +265144,8 @@ def: "The quality of a type III hypersensitivity." [AUTO:patterns/patterns/entit synonym: "quality of type III hypersensitivity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010139 ! immune response trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001802 ! type III hypersensitivity -relationship: inheres_in GO:0001802 ! type III hypersensitivity +intersection_of: RO:0000052 GO:0001802 ! inheres in type III hypersensitivity +relationship: RO:0000052 GO:0001802 ! inheres in type III hypersensitivity [Term] id: OBA:1000689 @@ -165799,8 +265154,8 @@ def: "The quality of a aldehyde oxidase activity." [AUTO:patterns/patterns/entit synonym: "quality of aldehyde oxidase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004031 ! aldehyde oxidase activity -relationship: inheres_in GO:0004031 ! aldehyde oxidase activity +intersection_of: RO:0000052 GO:0004031 ! inheres in aldehyde oxidase activity +relationship: RO:0000052 GO:0004031 ! inheres in aldehyde oxidase activity [Term] id: OBA:1000690 @@ -165809,8 +265164,8 @@ def: "The quality of a food consumption." [AUTO:patterns/patterns/entity_attribu synonym: "quality of food consumption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000748 ! feeding behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000134 ! food consumption -relationship: inheres_in NBO:0000134 ! food consumption +intersection_of: RO:0000052 NBO:0000134 ! inheres in food consumption +relationship: RO:0000052 NBO:0000134 ! inheres in food consumption [Term] id: OBA:1000691 @@ -165820,8 +265175,8 @@ synonym: "quality of circadian rhythm" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000369 ! behavior process quality is_a: OBA:VT0010455 ! rhythmic behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000166 ! circadian rhythm -relationship: inheres_in NBO:0000166 ! circadian rhythm +intersection_of: RO:0000052 NBO:0000166 ! inheres in circadian rhythm +relationship: RO:0000052 NBO:0000166 ! inheres in circadian rhythm [Term] id: OBA:1000692 @@ -165830,8 +265185,8 @@ def: "The quality of a procollagen-proline 4-dioxygenase activity." [AUTO:patter synonym: "quality of procollagen-proline 4-dioxygenase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004656 ! procollagen-proline 4-dioxygenase activity -relationship: inheres_in GO:0004656 ! procollagen-proline 4-dioxygenase activity +intersection_of: RO:0000052 GO:0004656 ! inheres in procollagen-proline 4-dioxygenase activity +relationship: RO:0000052 GO:0004656 ! inheres in procollagen-proline 4-dioxygenase activity [Term] id: OBA:1000693 @@ -165840,8 +265195,8 @@ def: "The quality of a mechanical nociceptive behavior." [AUTO:patterns/patterns synonym: "quality of mechanical nociceptive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000746 ! nociceptive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000334 ! mechanical nociceptive behavior -relationship: inheres_in NBO:0000334 ! mechanical nociceptive behavior +intersection_of: RO:0000052 NBO:0000334 ! inheres in mechanical nociceptive behavior +relationship: RO:0000052 NBO:0000334 ! inheres in mechanical nociceptive behavior [Term] id: OBA:1000694 @@ -165850,8 +265205,8 @@ def: "The quality of a venous sinus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of venous sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006615 ! venous sinus -relationship: inheres_in UBERON:0006615 ! venous sinus +intersection_of: RO:0000052 UBERON:0006615 ! inheres in venous sinus +relationship: RO:0000052 UBERON:0006615 ! inheres in venous sinus [Term] id: OBA:1000695 @@ -165860,8 +265215,8 @@ def: "The quality of a synchondrosis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of synchondrosis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002215 ! synchondrosis -relationship: inheres_in UBERON:0002215 ! synchondrosis +intersection_of: RO:0000052 UBERON:0002215 ! inheres in synchondrosis +relationship: RO:0000052 UBERON:0002215 ! inheres in synchondrosis [Term] id: OBA:1000696 @@ -165870,8 +265225,8 @@ def: "The quality of a paraxial mesoderm formation." [AUTO:patterns/patterns/ent synonym: "quality of paraxial mesoderm formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048341 ! paraxial mesoderm formation -relationship: inheres_in GO:0048341 ! paraxial mesoderm formation +intersection_of: RO:0000052 GO:0048341 ! inheres in paraxial mesoderm formation +relationship: RO:0000052 GO:0048341 ! inheres in paraxial mesoderm formation [Term] id: OBA:1000697 @@ -165880,8 +265235,8 @@ def: "The quality of a vestibular labyrinth." [AUTO:patterns/patterns/entity_att synonym: "quality of vestibular labyrinth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001862 ! vestibular labyrinth -relationship: inheres_in UBERON:0001862 ! vestibular labyrinth +intersection_of: RO:0000052 UBERON:0001862 ! inheres in vestibular labyrinth +relationship: RO:0000052 UBERON:0001862 ! inheres in vestibular labyrinth [Term] id: OBA:1000698 @@ -165890,8 +265245,8 @@ def: "The quality of a splanchnic layer of lateral plate mesoderm." [AUTO:patter synonym: "quality of splanchnic layer of lateral plate mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004872 ! splanchnic layer of lateral plate mesoderm -relationship: inheres_in UBERON:0004872 ! splanchnic layer of lateral plate mesoderm +intersection_of: RO:0000052 UBERON:0004872 ! inheres in splanchnic layer of lateral plate mesoderm +relationship: RO:0000052 UBERON:0004872 ! inheres in splanchnic layer of lateral plate mesoderm [Term] id: OBA:1000699 @@ -165900,8 +265255,8 @@ def: "The quality of a interphalangeal joint." [AUTO:patterns/patterns/entity_at synonym: "quality of interphalangeal joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000205 ! synovial joint quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006658 ! interphalangeal joint -relationship: inheres_in UBERON:0006658 ! interphalangeal joint +intersection_of: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint +relationship: RO:0000052 UBERON:0006658 ! inheres in interphalangeal joint [Term] id: OBA:1000700 @@ -165910,8 +265265,8 @@ def: "The quality of a renal system development." [AUTO:patterns/patterns/entity synonym: "quality of renal system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072001 ! renal system development -relationship: inheres_in GO:0072001 ! renal system development +intersection_of: RO:0000052 GO:0072001 ! inheres in renal system development +relationship: RO:0000052 GO:0072001 ! inheres in renal system development [Term] id: OBA:1000701 @@ -165920,8 +265275,8 @@ def: "The quality of a Z disc." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of Z disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030018 ! Z disc -relationship: inheres_in GO:0030018 ! Z disc +intersection_of: RO:0000052 GO:0030018 ! inheres in Z disc +relationship: RO:0000052 GO:0030018 ! inheres in Z disc [Term] id: OBA:1000702 @@ -165930,8 +265285,8 @@ def: "The quality of a tarsal gland development." [AUTO:patterns/patterns/entity synonym: "quality of tarsal gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903699 ! tarsal gland development -relationship: inheres_in GO:1903699 ! tarsal gland development +intersection_of: RO:0000052 GO:1903699 ! inheres in tarsal gland development +relationship: RO:0000052 GO:1903699 ! inheres in tarsal gland development [Term] id: OBA:1000703 @@ -165940,8 +265295,8 @@ def: "The quality of a purine-nucleoside phosphorylase activity." [AUTO:patterns synonym: "quality of purine-nucleoside phosphorylase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004731 ! purine-nucleoside phosphorylase activity -relationship: inheres_in GO:0004731 ! purine-nucleoside phosphorylase activity +intersection_of: RO:0000052 GO:0004731 ! inheres in purine-nucleoside phosphorylase activity +relationship: RO:0000052 GO:0004731 ! inheres in purine-nucleoside phosphorylase activity [Term] id: OBA:1000704 @@ -165950,8 +265305,8 @@ def: "The quality of a external acoustic meatus." [AUTO:patterns/patterns/entity synonym: "quality of external acoustic meatus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001352 ! external acoustic meatus -relationship: inheres_in UBERON:0001352 ! external acoustic meatus +intersection_of: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus +relationship: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus [Term] id: OBA:1000705 @@ -165960,8 +265315,8 @@ def: "The quality of a energy homeostasis." [AUTO:patterns/patterns/entity_attri synonym: "quality of energy homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001764 ! homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097009 ! energy homeostasis -relationship: inheres_in GO:0097009 ! energy homeostasis +intersection_of: RO:0000052 GO:0097009 ! inheres in energy homeostasis +relationship: RO:0000052 GO:0097009 ! inheres in energy homeostasis [Term] id: OBA:1000706 @@ -165970,8 +265325,8 @@ def: "The quality of a hydroxymethylbilane synthase activity." [AUTO:patterns/pa synonym: "quality of hydroxymethylbilane synthase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004418 ! hydroxymethylbilane synthase activity -relationship: inheres_in GO:0004418 ! hydroxymethylbilane synthase activity +intersection_of: RO:0000052 GO:0004418 ! inheres in hydroxymethylbilane synthase activity +relationship: RO:0000052 GO:0004418 ! inheres in hydroxymethylbilane synthase activity [Term] id: OBA:1000707 @@ -165980,8 +265335,8 @@ def: "The quality of a coping behavior." [AUTO:patterns/patterns/entity_attribut synonym: "quality of coping behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000103 ! coping behavior -relationship: inheres_in NBO:0000103 ! coping behavior +intersection_of: RO:0000052 NBO:0000103 ! inheres in coping behavior +relationship: RO:0000052 NBO:0000103 ! inheres in coping behavior [Term] id: OBA:1000708 @@ -165990,8 +265345,8 @@ def: "The quality of a clutching reflex." [AUTO:patterns/patterns/entity_attribu synonym: "quality of clutching reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000584 ! clutching reflex -relationship: inheres_in NBO:0000584 ! clutching reflex +intersection_of: RO:0000052 NBO:0000584 ! inheres in clutching reflex +relationship: RO:0000052 NBO:0000584 ! inheres in clutching reflex [Term] id: OBA:1000709 @@ -166000,8 +265355,8 @@ def: "The quality of a fibrinolysis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fibrinolysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001784 ! fluid regulation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042730 ! fibrinolysis -relationship: inheres_in GO:0042730 ! fibrinolysis +intersection_of: RO:0000052 GO:0042730 ! inheres in fibrinolysis +relationship: RO:0000052 GO:0042730 ! inheres in fibrinolysis [Term] id: OBA:1000710 @@ -166010,8 +265365,8 @@ def: "The quality of a trabecula of lymph node." [AUTO:patterns/patterns/entity_ synonym: "quality of trabecula of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002195 ! trabecula of lymph node -relationship: inheres_in UBERON:0002195 ! trabecula of lymph node +intersection_of: RO:0000052 UBERON:0002195 ! inheres in trabecula of lymph node +relationship: RO:0000052 UBERON:0002195 ! inheres in trabecula of lymph node [Term] id: OBA:1000711 @@ -166020,8 +265375,8 @@ def: "The quality of a chemically-elicited antinociceptive behavior." [AUTO:patt synonym: "quality of chemically-elicited antinociceptive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000746 ! nociceptive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000336 ! chemically-elicited antinociceptive behavior -relationship: inheres_in NBO:0000336 ! chemically-elicited antinociceptive behavior +intersection_of: RO:0000052 NBO:0000336 ! inheres in chemically-elicited antinociceptive behavior +relationship: RO:0000052 NBO:0000336 ! inheres in chemically-elicited antinociceptive behavior [Term] id: OBA:1000712 @@ -166030,8 +265385,8 @@ def: "The quality of a locomotor activation behavior." [AUTO:patterns/patterns/e synonym: "quality of locomotor activation behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000447 ! locomotor activation behavior -relationship: inheres_in NBO:0000447 ! locomotor activation behavior +intersection_of: RO:0000052 NBO:0000447 ! inheres in locomotor activation behavior +relationship: RO:0000052 NBO:0000447 ! inheres in locomotor activation behavior [Term] id: OBA:1000713 @@ -166040,8 +265395,8 @@ def: "The quality of a cutaneous sensation behavior." [AUTO:patterns/patterns/en synonym: "quality of cutaneous sensation behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000330 ! cutaneous sensation behavior -relationship: inheres_in NBO:0000330 ! cutaneous sensation behavior +intersection_of: RO:0000052 NBO:0000330 ! inheres in cutaneous sensation behavior +relationship: RO:0000052 NBO:0000330 ! inheres in cutaneous sensation behavior [Term] id: OBA:1000714 @@ -166050,8 +265405,8 @@ def: "The quality of a peroxidase activity." [AUTO:patterns/patterns/entity_attr synonym: "quality of peroxidase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004601 ! peroxidase activity -relationship: inheres_in GO:0004601 ! peroxidase activity +intersection_of: RO:0000052 GO:0004601 ! inheres in peroxidase activity +relationship: RO:0000052 GO:0004601 ! inheres in peroxidase activity [Term] id: OBA:1000715 @@ -166060,8 +265415,8 @@ def: "The quality of a lens induction in camera-type eye." [AUTO:patterns/patter synonym: "quality of lens induction in camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060235 ! lens induction in camera-type eye -relationship: inheres_in GO:0060235 ! lens induction in camera-type eye +intersection_of: RO:0000052 GO:0060235 ! inheres in lens induction in camera-type eye +relationship: RO:0000052 GO:0060235 ! inheres in lens induction in camera-type eye [Term] id: OBA:1000716 @@ -166070,8 +265425,8 @@ def: "The quality of a 5-aminolevulinate synthase activity." [AUTO:patterns/patt synonym: "quality of 5-aminolevulinate synthase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003870 ! 5-aminolevulinate synthase activity -relationship: inheres_in GO:0003870 ! 5-aminolevulinate synthase activity +intersection_of: RO:0000052 GO:0003870 ! inheres in 5-aminolevulinate synthase activity +relationship: RO:0000052 GO:0003870 ! inheres in 5-aminolevulinate synthase activity [Term] id: OBA:1000717 @@ -166080,8 +265435,8 @@ def: "The quality of a behavioral response to addictive substance." [AUTO:patter synonym: "quality of behavioral response to addictive substance" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000724 ! behavioral response to xenobiotics quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0001728 ! behavioral response to addictive substance -relationship: inheres_in NBO:0001728 ! behavioral response to addictive substance +intersection_of: RO:0000052 NBO:0001728 ! inheres in behavioral response to addictive substance +relationship: RO:0000052 NBO:0001728 ! inheres in behavioral response to addictive substance [Term] id: OBA:1000718 @@ -166090,8 +265445,8 @@ def: "The quality of a optokinetic reflex." [AUTO:patterns/patterns/entity_attri synonym: "quality of optokinetic reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000574 ! optokinetic reflex -relationship: inheres_in NBO:0000574 ! optokinetic reflex +intersection_of: RO:0000052 NBO:0000574 ! inheres in optokinetic reflex +relationship: RO:0000052 NBO:0000574 ! inheres in optokinetic reflex [Term] id: OBA:1000719 @@ -166100,8 +265455,8 @@ def: "The quality of a female meiotic nuclear division." [AUTO:patterns/patterns synonym: "quality of female meiotic nuclear division" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007143 ! female meiotic nuclear division -relationship: inheres_in GO:0007143 ! female meiotic nuclear division +intersection_of: RO:0000052 GO:0007143 ! inheres in female meiotic nuclear division +relationship: RO:0000052 GO:0007143 ! inheres in female meiotic nuclear division [Term] id: OBA:1000720 @@ -166110,8 +265465,8 @@ def: "The quality of a innervation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of innervation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060384 ! innervation -relationship: inheres_in GO:0060384 ! innervation +intersection_of: RO:0000052 GO:0060384 ! inheres in innervation +relationship: RO:0000052 GO:0060384 ! inheres in innervation [Term] id: OBA:1000721 @@ -166120,8 +265475,8 @@ def: "The quality of a catagen." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of catagen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042637 ! catagen -relationship: inheres_in GO:0042637 ! catagen +intersection_of: RO:0000052 GO:0042637 ! inheres in catagen +relationship: RO:0000052 GO:0042637 ! inheres in catagen [Term] id: OBA:1000722 @@ -166130,8 +265485,8 @@ def: "The quality of a gamete." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of gamete" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000300 ! gamete -relationship: inheres_in CL:0000300 ! gamete +intersection_of: RO:0000052 CL:0000300 ! inheres in gamete +relationship: RO:0000052 CL:0000300 ! inheres in gamete [Term] id: OBA:1000723 @@ -166140,8 +265495,8 @@ def: "The quality of a olfactory learning behavior." [AUTO:patterns/patterns/ent synonym: "quality of olfactory learning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000779 ! discrimination learning quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000172 ! olfactory learning behavior -relationship: inheres_in NBO:0000172 ! olfactory learning behavior +intersection_of: RO:0000052 NBO:0000172 ! inheres in olfactory learning behavior +relationship: RO:0000052 NBO:0000172 ! inheres in olfactory learning behavior [Term] id: OBA:1000724 @@ -166150,8 +265505,8 @@ def: "The quality of a behavioral response to xenobiotics." [AUTO:patterns/patte synonym: "quality of behavioral response to xenobiotics" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0001679 ! behavioral response to xenobiotics -relationship: inheres_in NBO:0001679 ! behavioral response to xenobiotics +intersection_of: RO:0000052 NBO:0001679 ! inheres in behavioral response to xenobiotics +relationship: RO:0000052 NBO:0001679 ! inheres in behavioral response to xenobiotics [Term] id: OBA:1000725 @@ -166160,8 +265515,8 @@ def: "The quality of a efferent duct." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of efferent duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006946 ! efferent duct -relationship: inheres_in UBERON:0006946 ! efferent duct +intersection_of: RO:0000052 UBERON:0006946 ! inheres in efferent duct +relationship: RO:0000052 UBERON:0006946 ! inheres in efferent duct [Term] id: OBA:1000726 @@ -166170,8 +265525,8 @@ def: "The quality of a head movement." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of head movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000678 ! body part movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000020 ! head movement -relationship: inheres_in NBO:0000020 ! head movement +intersection_of: RO:0000052 NBO:0000020 ! inheres in head movement +relationship: RO:0000052 NBO:0000020 ! inheres in head movement [Term] id: OBA:1000727 @@ -166180,8 +265535,8 @@ def: "The quality of a multicellular organismal movement." [AUTO:patterns/patter synonym: "quality of multicellular organismal movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050879 ! multicellular organismal movement -relationship: inheres_in GO:0050879 ! multicellular organismal movement +intersection_of: RO:0000052 GO:0050879 ! inheres in multicellular organismal movement +relationship: RO:0000052 GO:0050879 ! inheres in multicellular organismal movement [Term] id: OBA:1000728 @@ -166190,8 +265545,8 @@ def: "The quality of a pyruvate kinase activity." [AUTO:patterns/patterns/entity synonym: "quality of pyruvate kinase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004743 ! pyruvate kinase activity -relationship: inheres_in GO:0004743 ! pyruvate kinase activity +intersection_of: RO:0000052 GO:0004743 ! inheres in pyruvate kinase activity +relationship: RO:0000052 GO:0004743 ! inheres in pyruvate kinase activity [Term] id: OBA:1000729 @@ -166200,8 +265555,8 @@ def: "The quality of a long term object recognition memory." [AUTO:patterns/patt synonym: "quality of long term object recognition memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000862 ! visual object recognition quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000552 ! long term object recognition memory -relationship: inheres_in NBO:0000552 ! long term object recognition memory +intersection_of: RO:0000052 NBO:0000552 ! inheres in long term object recognition memory +relationship: RO:0000052 NBO:0000552 ! inheres in long term object recognition memory [Term] id: OBA:1000730 @@ -166210,8 +265565,8 @@ def: "The quality of a cortex of lymph node." [AUTO:patterns/patterns/entity_att synonym: "quality of cortex of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002006 ! cortex of lymph node -relationship: inheres_in UBERON:0002006 ! cortex of lymph node +intersection_of: RO:0000052 UBERON:0002006 ! inheres in cortex of lymph node +relationship: RO:0000052 UBERON:0002006 ! inheres in cortex of lymph node [Term] id: OBA:1000731 @@ -166220,8 +265575,8 @@ def: "The quality of a nest building behavior." [AUTO:patterns/patterns/entity_a synonym: "quality of nest building behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000157 ! nest building behavior -relationship: inheres_in NBO:0000157 ! nest building behavior +intersection_of: RO:0000052 NBO:0000157 ! inheres in nest building behavior +relationship: RO:0000052 NBO:0000157 ! inheres in nest building behavior [Term] id: OBA:1000732 @@ -166230,8 +265585,8 @@ def: "The quality of a glucokinase activity." [AUTO:patterns/patterns/entity_att synonym: "quality of glucokinase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004340 ! glucokinase activity -relationship: inheres_in GO:0004340 ! glucokinase activity +intersection_of: RO:0000052 GO:0004340 ! inheres in glucokinase activity +relationship: RO:0000052 GO:0004340 ! inheres in glucokinase activity [Term] id: OBA:1000733 @@ -166240,8 +265595,8 @@ def: "The quality of a response to novel environment." [AUTO:patterns/patterns/e synonym: "quality of response to novel environment" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000891 ! novelty response behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000097 ! response to novel environment -relationship: inheres_in NBO:0000097 ! response to novel environment +intersection_of: RO:0000052 NBO:0000097 ! inheres in response to novel environment +relationship: RO:0000052 NBO:0000097 ! inheres in response to novel environment [Term] id: OBA:1000734 @@ -166250,8 +265605,8 @@ def: "The quality of a male meiotic nuclear division." [AUTO:patterns/patterns/e synonym: "quality of male meiotic nuclear division" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007140 ! male meiotic nuclear division -relationship: inheres_in GO:0007140 ! male meiotic nuclear division +intersection_of: RO:0000052 GO:0007140 ! inheres in male meiotic nuclear division +relationship: RO:0000052 GO:0007140 ! inheres in male meiotic nuclear division [Term] id: OBA:1000735 @@ -166260,8 +265615,8 @@ def: "The quality of a head shaking." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of head shaking" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000726 ! head movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000023 ! head shaking -relationship: inheres_in NBO:0000023 ! head shaking +intersection_of: RO:0000052 NBO:0000023 ! inheres in head shaking +relationship: RO:0000052 NBO:0000023 ! inheres in head shaking [Term] id: OBA:1000736 @@ -166270,8 +265625,8 @@ def: "The quality of a lymph node T cell domain." [AUTO:patterns/patterns/entity synonym: "quality of lymph node T cell domain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010417 ! lymph node T cell domain -relationship: inheres_in UBERON:0010417 ! lymph node T cell domain +intersection_of: RO:0000052 UBERON:0010417 ! inheres in lymph node T cell domain +relationship: RO:0000052 UBERON:0010417 ! inheres in lymph node T cell domain [Term] id: OBA:1000737 @@ -166280,8 +265635,8 @@ def: "The quality of a pinna reflex." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of pinna reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000576 ! pinna reflex -relationship: inheres_in NBO:0000576 ! pinna reflex +intersection_of: RO:0000052 NBO:0000576 ! inheres in pinna reflex +relationship: RO:0000052 NBO:0000576 ! inheres in pinna reflex [Term] id: OBA:1000738 @@ -166290,8 +265645,8 @@ def: "The quality of a fornix of brain." [AUTO:patterns/patterns/entity_attribut synonym: "quality of fornix of brain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000052 ! fornix of brain -relationship: inheres_in UBERON:0000052 ! fornix of brain +intersection_of: RO:0000052 UBERON:0000052 ! inheres in fornix of brain +relationship: RO:0000052 UBERON:0000052 ! inheres in fornix of brain [Term] id: OBA:1000739 @@ -166300,8 +265655,8 @@ def: "The quality of a mating receptivity." [AUTO:patterns/patterns/entity_attri synonym: "quality of mating receptivity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000809 ! mating behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000146 ! mating receptivity -relationship: inheres_in NBO:0000146 ! mating receptivity +intersection_of: RO:0000052 NBO:0000146 ! inheres in mating receptivity +relationship: RO:0000052 NBO:0000146 ! inheres in mating receptivity [Term] id: OBA:1000740 @@ -166310,8 +265665,8 @@ def: "The quality of a pharyngotympanic tube." [AUTO:patterns/patterns/entity_at synonym: "quality of pharyngotympanic tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002393 ! pharyngotympanic tube -relationship: inheres_in UBERON:0002393 ! pharyngotympanic tube +intersection_of: RO:0000052 UBERON:0002393 ! inheres in pharyngotympanic tube +relationship: RO:0000052 UBERON:0002393 ! inheres in pharyngotympanic tube [Term] id: OBA:1000741 @@ -166320,8 +265675,8 @@ def: "The quality of a reflexive behavior." [AUTO:patterns/patterns/entity_attri synonym: "quality of reflexive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000885 ! involuntary movement behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000389 ! reflexive behavior -relationship: inheres_in NBO:0000389 ! reflexive behavior +intersection_of: RO:0000052 NBO:0000389 ! inheres in reflexive behavior +relationship: RO:0000052 NBO:0000389 ! inheres in reflexive behavior [Term] id: OBA:1000742 @@ -166330,8 +265685,8 @@ def: "The quality of a nitric oxide homeostasis." [AUTO:patterns/patterns/entity synonym: "quality of nitric oxide homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000846 ! gas homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033484 ! nitric oxide homeostasis -relationship: inheres_in GO:0033484 ! nitric oxide homeostasis +intersection_of: RO:0000052 GO:0033484 ! inheres in nitric oxide homeostasis +relationship: RO:0000052 GO:0033484 ! inheres in nitric oxide homeostasis [Term] id: OBA:1000743 @@ -166340,8 +265695,8 @@ def: "The quality of a response to light stimulus." [AUTO:patterns/patterns/enti synonym: "quality of response to light stimulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009416 ! response to light stimulus -relationship: inheres_in GO:0009416 ! response to light stimulus +intersection_of: RO:0000052 GO:0009416 ! inheres in response to light stimulus +relationship: RO:0000052 GO:0009416 ! inheres in response to light stimulus [Term] id: OBA:1000744 @@ -166350,8 +265705,8 @@ def: "The quality of a glutamate decarboxylase activity." [AUTO:patterns/pattern synonym: "quality of glutamate decarboxylase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004351 ! glutamate decarboxylase activity -relationship: inheres_in GO:0004351 ! glutamate decarboxylase activity +intersection_of: RO:0000052 GO:0004351 ! inheres in glutamate decarboxylase activity +relationship: RO:0000052 GO:0004351 ! inheres in glutamate decarboxylase activity [Term] id: OBA:1000745 @@ -166360,8 +265715,8 @@ def: "The quality of a umbilical artery." [AUTO:patterns/patterns/entity_attribu synonym: "quality of umbilical artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000414 ! umbilical blood vessel quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001310 ! umbilical artery -relationship: inheres_in UBERON:0001310 ! umbilical artery +intersection_of: RO:0000052 UBERON:0001310 ! inheres in umbilical artery +relationship: RO:0000052 UBERON:0001310 ! inheres in umbilical artery [Term] id: OBA:1000746 @@ -166370,8 +265725,8 @@ def: "The quality of a nociceptive behavior." [AUTO:patterns/patterns/entity_att synonym: "quality of nociceptive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000713 ! cutaneous sensation behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000331 ! nociceptive behavior -relationship: inheres_in NBO:0000331 ! nociceptive behavior +intersection_of: RO:0000052 NBO:0000331 ! inheres in nociceptive behavior +relationship: RO:0000052 NBO:0000331 ! inheres in nociceptive behavior [Term] id: OBA:1000747 @@ -166381,8 +265736,8 @@ synonym: "quality of maternal grooming" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000656 ! social grooming quality is_a: OBA:1000687 ! maternal nurturing behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000559 ! maternal grooming -relationship: inheres_in NBO:0000559 ! maternal grooming +intersection_of: RO:0000052 NBO:0000559 ! inheres in maternal grooming +relationship: RO:0000052 NBO:0000559 ! inheres in maternal grooming [Term] id: OBA:1000748 @@ -166391,8 +265746,8 @@ def: "The quality of a feeding behavior." [AUTO:patterns/patterns/entity_attribu synonym: "quality of feeding behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000079 ! feeding behavior -relationship: inheres_in NBO:0000079 ! feeding behavior +intersection_of: RO:0000052 NBO:0000079 ! inheres in feeding behavior +relationship: RO:0000052 NBO:0000079 ! inheres in feeding behavior [Term] id: OBA:1000749 @@ -166401,8 +265756,8 @@ def: "The quality of a foliate papilla." [AUTO:patterns/patterns/entity_attribut synonym: "quality of foliate papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000878 ! papilla of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002468 ! foliate papilla -relationship: inheres_in UBERON:0002468 ! foliate papilla +intersection_of: RO:0000052 UBERON:0002468 ! inheres in foliate papilla +relationship: RO:0000052 UBERON:0002468 ! inheres in foliate papilla [Term] id: OBA:1000750 @@ -166411,8 +265766,8 @@ def: "The quality of a keratinocyte apoptotic process." [AUTO:patterns/patterns/ synonym: "quality of keratinocyte apoptotic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097283 ! keratinocyte apoptotic process -relationship: inheres_in GO:0097283 ! keratinocyte apoptotic process +intersection_of: RO:0000052 GO:0097283 ! inheres in keratinocyte apoptotic process +relationship: RO:0000052 GO:0097283 ! inheres in keratinocyte apoptotic process [Term] id: OBA:1000751 @@ -166421,8 +265776,8 @@ def: "The quality of a wound healing." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of wound healing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042060 ! wound healing -relationship: inheres_in GO:0042060 ! wound healing +intersection_of: RO:0000052 GO:0042060 ! inheres in wound healing +relationship: RO:0000052 GO:0042060 ! inheres in wound healing [Term] id: OBA:1000752 @@ -166431,8 +265786,8 @@ def: "The quality of a proestrus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of proestrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060208 ! proestrus -relationship: inheres_in GO:0060208 ! proestrus +intersection_of: RO:0000052 GO:0060208 ! inheres in proestrus +relationship: RO:0000052 GO:0060208 ! inheres in proestrus [Term] id: OBA:1000753 @@ -166441,8 +265796,8 @@ def: "The quality of a maternal behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of maternal behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000150 ! maternal behavior -relationship: inheres_in NBO:0000150 ! maternal behavior +intersection_of: RO:0000052 NBO:0000150 ! inheres in maternal behavior +relationship: RO:0000052 NBO:0000150 ! inheres in maternal behavior [Term] id: OBA:1000754 @@ -166451,8 +265806,8 @@ def: "The quality of a basilar membrane of cochlea." [AUTO:patterns/patterns/ent synonym: "quality of basilar membrane of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002226 ! basilar membrane of cochlea -relationship: inheres_in UBERON:0002226 ! basilar membrane of cochlea +intersection_of: RO:0000052 UBERON:0002226 ! inheres in basilar membrane of cochlea +relationship: RO:0000052 UBERON:0002226 ! inheres in basilar membrane of cochlea [Term] id: OBA:1000755 @@ -166461,8 +265816,8 @@ def: "The quality of a zona pellucida." [AUTO:patterns/patterns/entity_attribute synonym: "quality of zona pellucida" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000086 ! zona pellucida -relationship: inheres_in UBERON:0000086 ! zona pellucida +intersection_of: RO:0000052 UBERON:0000086 ! inheres in zona pellucida +relationship: RO:0000052 UBERON:0000086 ! inheres in zona pellucida [Term] id: OBA:1000756 @@ -166471,8 +265826,8 @@ def: "The quality of a endochondral ossification." [AUTO:patterns/patterns/entit synonym: "quality of endochondral ossification" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000057 ! ossification trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001958 ! endochondral ossification -relationship: inheres_in GO:0001958 ! endochondral ossification +intersection_of: RO:0000052 GO:0001958 ! inheres in endochondral ossification +relationship: RO:0000052 GO:0001958 ! inheres in endochondral ossification [Term] id: OBA:1000757 @@ -166481,8 +265836,8 @@ def: "The quality of a posture." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of posture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000355 ! posture -relationship: inheres_in NBO:0000355 ! posture +intersection_of: RO:0000052 NBO:0000355 ! inheres in posture +relationship: RO:0000052 NBO:0000355 ! inheres in posture [Term] id: OBA:1000758 @@ -166491,8 +265846,8 @@ def: "The quality of a Rathke's pouch." [AUTO:patterns/patterns/entity_attribute synonym: "quality of Rathke's pouch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005356 ! Rathke's pouch -relationship: inheres_in UBERON:0005356 ! Rathke's pouch +intersection_of: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch +relationship: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch [Term] id: OBA:1000759 @@ -166501,8 +265856,8 @@ def: "The quality of a inferior olivary complex." [AUTO:patterns/patterns/entity synonym: "quality of inferior olivary complex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002127 ! inferior olivary complex -relationship: inheres_in UBERON:0002127 ! inferior olivary complex +intersection_of: RO:0000052 UBERON:0002127 ! inheres in inferior olivary complex +relationship: RO:0000052 UBERON:0002127 ! inheres in inferior olivary complex [Term] id: OBA:1000760 @@ -166512,8 +265867,8 @@ synonym: "quality of submissive behavior towards male mice" EXACT [AUTO:patterns is_a: OBA:1000407 ! social behavior quality is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000125 ! submissive behavior towards male mice -relationship: inheres_in NBO:0000125 ! submissive behavior towards male mice +intersection_of: RO:0000052 NBO:0000125 ! inheres in submissive behavior towards male mice +relationship: RO:0000052 NBO:0000125 ! inheres in submissive behavior towards male mice [Term] id: OBA:1000761 @@ -166522,8 +265877,8 @@ def: "The quality of a gastric gland." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of gastric gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000325 ! gastric gland -relationship: inheres_in UBERON:0000325 ! gastric gland +intersection_of: RO:0000052 UBERON:0000325 ! inheres in gastric gland +relationship: RO:0000052 UBERON:0000325 ! inheres in gastric gland [Term] id: OBA:1000762 @@ -166532,8 +265887,8 @@ def: "The quality of a neuronal ion channel clustering." [AUTO:patterns/patterns synonym: "quality of neuronal ion channel clustering" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045161 ! neuronal ion channel clustering -relationship: inheres_in GO:0045161 ! neuronal ion channel clustering +intersection_of: RO:0000052 GO:0045161 ! inheres in neuronal ion channel clustering +relationship: RO:0000052 GO:0045161 ! inheres in neuronal ion channel clustering [Term] id: OBA:1000763 @@ -166542,8 +265897,8 @@ def: "The quality of a photoreceptor outer segment." [AUTO:patterns/patterns/ent synonym: "quality of photoreceptor outer segment" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment -relationship: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment +relationship: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:1000764 @@ -166552,8 +265907,8 @@ def: "The quality of a bone marrow cell." [AUTO:patterns/patterns/entity_attribu synonym: "quality of bone marrow cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0002092 ! bone marrow cell -relationship: inheres_in CL:0002092 ! bone marrow cell +intersection_of: RO:0000052 CL:0002092 ! inheres in bone marrow cell +relationship: RO:0000052 CL:0002092 ! inheres in bone marrow cell [Term] id: OBA:1000765 @@ -166563,8 +265918,8 @@ synonym: "quality of circadian regulation of systemic arterial blood pressure" E is_a: OBA:1000369 ! behavior process quality is_a: OBA:VT0010455 ! rhythmic behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000537 ! circadian regulation of systemic arterial blood pressure -relationship: inheres_in NBO:0000537 ! circadian regulation of systemic arterial blood pressure +intersection_of: RO:0000052 NBO:0000537 ! inheres in circadian regulation of systemic arterial blood pressure +relationship: RO:0000052 NBO:0000537 ! inheres in circadian regulation of systemic arterial blood pressure [Term] id: OBA:1000766 @@ -166573,8 +265928,8 @@ def: "The quality of a catechol O-methyltransferase activity." [AUTO:patterns/pa synonym: "quality of catechol O-methyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0016206 ! catechol O-methyltransferase activity -relationship: inheres_in GO:0016206 ! catechol O-methyltransferase activity +intersection_of: RO:0000052 GO:0016206 ! inheres in catechol O-methyltransferase activity +relationship: RO:0000052 GO:0016206 ! inheres in catechol O-methyltransferase activity [Term] id: OBA:1000767 @@ -166583,8 +265938,8 @@ def: "The quality of a depression behavior." [AUTO:patterns/patterns/entity_attr synonym: "quality of depression behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000085 ! depression behavior -relationship: inheres_in NBO:0000085 ! depression behavior +intersection_of: RO:0000052 NBO:0000085 ! inheres in depression behavior +relationship: RO:0000052 NBO:0000085 ! inheres in depression behavior [Term] id: OBA:1000768 @@ -166593,8 +265948,8 @@ def: "The quality of a active avoidance learning behavior." [AUTO:patterns/patte synonym: "quality of active avoidance learning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000845 ! avoidance learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000217 ! active avoidance learning behavior -relationship: inheres_in NBO:0000217 ! active avoidance learning behavior +intersection_of: RO:0000052 NBO:0000217 ! inheres in active avoidance learning behavior +relationship: RO:0000052 NBO:0000217 ! inheres in active avoidance learning behavior [Term] id: OBA:1000769 @@ -166603,8 +265958,8 @@ def: "The quality of a diestrus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of diestrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060207 ! diestrus -relationship: inheres_in GO:0060207 ! diestrus +intersection_of: RO:0000052 GO:0060207 ! inheres in diestrus +relationship: RO:0000052 GO:0060207 ! inheres in diestrus [Term] id: OBA:1000770 @@ -166613,8 +265968,8 @@ def: "The quality of a palmitoyl-(protein) hydrolase activity." [AUTO:patterns/p synonym: "quality of palmitoyl-(protein) hydrolase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008474 ! palmitoyl-(protein) hydrolase activity -relationship: inheres_in GO:0008474 ! palmitoyl-(protein) hydrolase activity +intersection_of: RO:0000052 GO:0008474 ! inheres in palmitoyl-(protein) hydrolase activity +relationship: RO:0000052 GO:0008474 ! inheres in palmitoyl-(protein) hydrolase activity [Term] id: OBA:1000771 @@ -166623,8 +265978,8 @@ def: "The quality of a multidirectional head movement." [AUTO:patterns/patterns/ synonym: "quality of multidirectional head movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000726 ! head movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000571 ! multidirectional head movement -relationship: inheres_in NBO:0000571 ! multidirectional head movement +intersection_of: RO:0000052 NBO:0000571 ! inheres in multidirectional head movement +relationship: RO:0000052 NBO:0000571 ! inheres in multidirectional head movement [Term] id: OBA:1000772 @@ -166633,8 +265988,8 @@ def: "The quality of a post-anal tail morphogenesis." [AUTO:patterns/patterns/en synonym: "quality of post-anal tail morphogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0036342 ! post-anal tail morphogenesis -relationship: inheres_in GO:0036342 ! post-anal tail morphogenesis +intersection_of: RO:0000052 GO:0036342 ! inheres in post-anal tail morphogenesis +relationship: RO:0000052 GO:0036342 ! inheres in post-anal tail morphogenesis [Term] id: OBA:1000773 @@ -166643,8 +265998,8 @@ def: "The quality of a corneocyte desquamation." [AUTO:patterns/patterns/entity_ synonym: "quality of corneocyte desquamation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003336 ! corneocyte desquamation -relationship: inheres_in GO:0003336 ! corneocyte desquamation +intersection_of: RO:0000052 GO:0003336 ! inheres in corneocyte desquamation +relationship: RO:0000052 GO:0003336 ! inheres in corneocyte desquamation [Term] id: OBA:1000774 @@ -166653,8 +266008,8 @@ def: "The quality of a vestibulocollic reflex." [AUTO:patterns/patterns/entity_a synonym: "quality of vestibulocollic reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000871 ! postural reflex quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000581 ! vestibulocollic reflex -relationship: inheres_in NBO:0000581 ! vestibulocollic reflex +intersection_of: RO:0000052 NBO:0000581 ! inheres in vestibulocollic reflex +relationship: RO:0000052 NBO:0000581 ! inheres in vestibulocollic reflex [Term] id: OBA:1000775 @@ -166663,8 +266018,8 @@ def: "The quality of a motor coordination." [AUTO:patterns/patterns/entity_attri synonym: "quality of motor coordination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000339 ! motor coordination -relationship: inheres_in NBO:0000339 ! motor coordination +intersection_of: RO:0000052 NBO:0000339 ! inheres in motor coordination +relationship: RO:0000052 NBO:0000339 ! inheres in motor coordination [Term] id: OBA:1000776 @@ -166673,8 +266028,8 @@ def: "The quality of a choline O-acetyltransferase activity." [AUTO:patterns/pat synonym: "quality of choline O-acetyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004102 ! choline O-acetyltransferase activity -relationship: inheres_in GO:0004102 ! choline O-acetyltransferase activity +intersection_of: RO:0000052 GO:0004102 ! inheres in choline O-acetyltransferase activity +relationship: RO:0000052 GO:0004102 ! inheres in choline O-acetyltransferase activity [Term] id: OBA:1000777 @@ -166683,8 +266038,8 @@ def: "The quality of a hair medulla." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hair medulla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005184 ! hair medulla -relationship: inheres_in UBERON:0005184 ! hair medulla +intersection_of: RO:0000052 UBERON:0005184 ! inheres in hair medulla +relationship: RO:0000052 UBERON:0005184 ! inheres in hair medulla [Term] id: OBA:1000778 @@ -166693,8 +266048,8 @@ def: "The quality of a epididymal fat pad." [AUTO:patterns/patterns/entity_attri synonym: "quality of epididymal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010412 ! epididymal fat pad -relationship: inheres_in UBERON:0010412 ! epididymal fat pad +intersection_of: RO:0000052 UBERON:0010412 ! inheres in epididymal fat pad +relationship: RO:0000052 UBERON:0010412 ! inheres in epididymal fat pad [Term] id: OBA:1000779 @@ -166703,8 +266058,8 @@ def: "The quality of a discrimination learning." [AUTO:patterns/patterns/entity_ synonym: "quality of discrimination learning" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000641 ! discrimination learning -relationship: inheres_in NBO:0000641 ! discrimination learning +intersection_of: RO:0000052 NBO:0000641 ! inheres in discrimination learning +relationship: RO:0000052 NBO:0000641 ! inheres in discrimination learning [Term] id: OBA:1000780 @@ -166713,8 +266068,8 @@ def: "The quality of a posterior semicircular canal." [AUTO:patterns/patterns/en synonym: "quality of posterior semicircular canal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001842 ! posterior semicircular canal -relationship: inheres_in UBERON:0001842 ! posterior semicircular canal +intersection_of: RO:0000052 UBERON:0001842 ! inheres in posterior semicircular canal +relationship: RO:0000052 UBERON:0001842 ! inheres in posterior semicircular canal [Term] id: OBA:1000781 @@ -166723,8 +266078,8 @@ def: "The quality of a axo-dendritic transport." [AUTO:patterns/patterns/entity_ synonym: "quality of axo-dendritic transport" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008088 ! axo-dendritic transport -relationship: inheres_in GO:0008088 ! axo-dendritic transport +intersection_of: RO:0000052 GO:0008088 ! inheres in axo-dendritic transport +relationship: RO:0000052 GO:0008088 ! inheres in axo-dendritic transport [Term] id: OBA:1000782 @@ -166733,8 +266088,8 @@ def: "The quality of a otolith organ." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of otolith organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002518 ! otolith organ -relationship: inheres_in UBERON:0002518 ! otolith organ +intersection_of: RO:0000052 UBERON:0002518 ! inheres in otolith organ +relationship: RO:0000052 UBERON:0002518 ! inheres in otolith organ [Term] id: OBA:1000783 @@ -166743,8 +266098,8 @@ def: "The quality of a Purkinje cell layer of cerebellar cortex." [AUTO:patterns synonym: "quality of Purkinje cell layer of cerebellar cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002979 ! Purkinje cell layer of cerebellar cortex -relationship: inheres_in UBERON:0002979 ! Purkinje cell layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002979 ! inheres in Purkinje cell layer of cerebellar cortex +relationship: RO:0000052 UBERON:0002979 ! inheres in Purkinje cell layer of cerebellar cortex [Term] id: OBA:1000784 @@ -166753,8 +266108,8 @@ def: "The quality of a limb posture." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of limb posture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000757 ! posture quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000357 ! limb posture -relationship: inheres_in NBO:0000357 ! limb posture +intersection_of: RO:0000052 NBO:0000357 ! inheres in limb posture +relationship: RO:0000052 NBO:0000357 ! inheres in limb posture [Term] id: OBA:1000785 @@ -166763,8 +266118,8 @@ def: "The quality of a postzygapophysis." [AUTO:patterns/patterns/entity_attribu synonym: "quality of postzygapophysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001080 ! postzygapophysis -relationship: inheres_in UBERON:0001080 ! postzygapophysis +intersection_of: RO:0000052 UBERON:0001080 ! inheres in postzygapophysis +relationship: RO:0000052 UBERON:0001080 ! inheres in postzygapophysis [Term] id: OBA:1000786 @@ -166773,8 +266128,8 @@ def: "The quality of a long-term spatial memory." [AUTO:patterns/patterns/entity synonym: "quality of long-term spatial memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000858 ! spatial memory quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000599 ! long-term spatial memory -relationship: inheres_in NBO:0000599 ! long-term spatial memory +intersection_of: RO:0000052 NBO:0000599 ! inheres in long-term spatial memory +relationship: RO:0000052 NBO:0000599 ! inheres in long-term spatial memory [Term] id: OBA:1000787 @@ -166783,8 +266138,8 @@ def: "The quality of a lymph node primary follicle." [AUTO:patterns/patterns/ent synonym: "quality of lymph node primary follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010395 ! lymph node primary follicle -relationship: inheres_in UBERON:0010395 ! lymph node primary follicle +intersection_of: RO:0000052 UBERON:0010395 ! inheres in lymph node primary follicle +relationship: RO:0000052 UBERON:0010395 ! inheres in lymph node primary follicle [Term] id: OBA:1000788 @@ -166793,8 +266148,8 @@ def: "The quality of a cued conditioning behavior." [AUTO:patterns/patterns/enti synonym: "quality of cued conditioning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000224 ! cued conditioning behavior -relationship: inheres_in NBO:0000224 ! cued conditioning behavior +intersection_of: RO:0000052 NBO:0000224 ! inheres in cued conditioning behavior +relationship: RO:0000052 NBO:0000224 ! inheres in cued conditioning behavior [Term] id: OBA:1000789 @@ -166803,8 +266158,8 @@ def: "The quality of a glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphor synonym: "quality of glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity -relationship: inheres_in GO:0004365 ! glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity +intersection_of: RO:0000052 GO:0004365 ! inheres in glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity +relationship: RO:0000052 GO:0004365 ! inheres in glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [Term] id: OBA:1000790 @@ -166813,8 +266168,8 @@ def: "The quality of a sciatic nerve." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of sciatic nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000471 ! nerve quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001322 ! sciatic nerve -relationship: inheres_in UBERON:0001322 ! sciatic nerve +intersection_of: RO:0000052 UBERON:0001322 ! inheres in sciatic nerve +relationship: RO:0000052 UBERON:0001322 ! inheres in sciatic nerve [Term] id: OBA:1000791 @@ -166828,8 +266183,8 @@ def: "The quality of a vitelline vasculature." [AUTO:patterns/patterns/entity_at synonym: "quality of vitelline vasculature" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004374 ! vitelline vasculature -relationship: inheres_in UBERON:0004374 ! vitelline vasculature +intersection_of: RO:0000052 UBERON:0004374 ! inheres in vitelline vasculature +relationship: RO:0000052 UBERON:0004374 ! inheres in vitelline vasculature [Term] id: OBA:1000793 @@ -166838,8 +266193,8 @@ def: "The quality of a pupillary light reflex." [AUTO:patterns/patterns/entity_a synonym: "quality of pupillary light reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000412 ! pupillary light reflex -relationship: inheres_in NBO:0000412 ! pupillary light reflex +intersection_of: RO:0000052 NBO:0000412 ! inheres in pupillary light reflex +relationship: RO:0000052 NBO:0000412 ! inheres in pupillary light reflex [Term] id: OBA:1000794 @@ -166848,8 +266203,8 @@ def: "The quality of a penile erection." [AUTO:patterns/patterns/entity_attribut synonym: "quality of penile erection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043084 ! penile erection -relationship: inheres_in GO:0043084 ! penile erection +intersection_of: RO:0000052 GO:0043084 ! inheres in penile erection +relationship: RO:0000052 GO:0043084 ! inheres in penile erection [Term] id: OBA:1000795 @@ -166858,8 +266213,8 @@ def: "The quality of a somatic layer of lateral plate mesoderm." [AUTO:patterns/ synonym: "quality of somatic layer of lateral plate mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004871 ! somatic layer of lateral plate mesoderm -relationship: inheres_in UBERON:0004871 ! somatic layer of lateral plate mesoderm +intersection_of: RO:0000052 UBERON:0004871 ! inheres in somatic layer of lateral plate mesoderm +relationship: RO:0000052 UBERON:0004871 ! inheres in somatic layer of lateral plate mesoderm [Term] id: OBA:1000796 @@ -166868,8 +266223,8 @@ def: "The quality of a cloaca development." [AUTO:patterns/patterns/entity_attri synonym: "quality of cloaca development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0035844 ! cloaca development -relationship: inheres_in GO:0035844 ! cloaca development +intersection_of: RO:0000052 GO:0035844 ! inheres in cloaca development +relationship: RO:0000052 GO:0035844 ! inheres in cloaca development [Term] id: OBA:1000797 @@ -166878,8 +266233,8 @@ def: "The quality of a glutathione peroxidase activity." [AUTO:patterns/patterns synonym: "quality of glutathione peroxidase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000714 ! peroxidase activity quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004602 ! glutathione peroxidase activity -relationship: inheres_in GO:0004602 ! glutathione peroxidase activity +intersection_of: RO:0000052 GO:0004602 ! inheres in glutathione peroxidase activity +relationship: RO:0000052 GO:0004602 ! inheres in glutathione peroxidase activity [Term] id: OBA:1000798 @@ -166888,8 +266243,8 @@ def: "The quality of a blood vessel elastic tissue." [AUTO:patterns/patterns/ent synonym: "quality of blood vessel elastic tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100002 ! connective tissue trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003614 ! blood vessel elastic tissue -relationship: inheres_in UBERON:0003614 ! blood vessel elastic tissue +intersection_of: RO:0000052 UBERON:0003614 ! inheres in blood vessel elastic tissue +relationship: RO:0000052 UBERON:0003614 ! inheres in blood vessel elastic tissue [Term] id: OBA:1000799 @@ -166898,8 +266253,8 @@ def: "The quality of a behavioral response to anesthetic." [AUTO:patterns/patter synonym: "quality of behavioral response to anesthetic" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000724 ! behavioral response to xenobiotics quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0002362 ! behavioral response to anesthetic -relationship: inheres_in NBO:0002362 ! behavioral response to anesthetic +intersection_of: RO:0000052 NBO:0002362 ! inheres in behavioral response to anesthetic +relationship: RO:0000052 NBO:0002362 ! inheres in behavioral response to anesthetic [Term] id: OBA:1000800 @@ -166908,8 +266263,8 @@ def: "The quality of a thiopurine S-methyltransferase activity." [AUTO:patterns/ synonym: "quality of thiopurine S-methyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008119 ! thiopurine S-methyltransferase activity -relationship: inheres_in GO:0008119 ! thiopurine S-methyltransferase activity +intersection_of: RO:0000052 GO:0008119 ! inheres in thiopurine S-methyltransferase activity +relationship: RO:0000052 GO:0008119 ! inheres in thiopurine S-methyltransferase activity [Term] id: OBA:1000801 @@ -166918,8 +266273,8 @@ def: "The quality of a vallate papilla." [AUTO:patterns/patterns/entity_attribut synonym: "quality of vallate papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000878 ! papilla of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000396 ! vallate papilla -relationship: inheres_in UBERON:0000396 ! vallate papilla +intersection_of: RO:0000052 UBERON:0000396 ! inheres in vallate papilla +relationship: RO:0000052 UBERON:0000396 ! inheres in vallate papilla [Term] id: OBA:1000802 @@ -166928,8 +266283,8 @@ def: "The quality of a anterior semicircular canal." [AUTO:patterns/patterns/ent synonym: "quality of anterior semicircular canal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001841 ! anterior semicircular canal -relationship: inheres_in UBERON:0001841 ! anterior semicircular canal +intersection_of: RO:0000052 UBERON:0001841 ! inheres in anterior semicircular canal +relationship: RO:0000052 UBERON:0001841 ! inheres in anterior semicircular canal [Term] id: OBA:1000803 @@ -166943,8 +266298,8 @@ def: "The quality of a spatial learning." [AUTO:patterns/patterns/entity_attribu synonym: "quality of spatial learning" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000175 ! spatial learning -relationship: inheres_in NBO:0000175 ! spatial learning +intersection_of: RO:0000052 NBO:0000175 ! inheres in spatial learning +relationship: RO:0000052 NBO:0000175 ! inheres in spatial learning [Term] id: OBA:1000805 @@ -166953,8 +266308,8 @@ def: "The quality of a respiratory gaseous exchange by respiratory system." [AUT synonym: "quality of respiratory gaseous exchange by respiratory system" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007585 ! respiratory gaseous exchange by respiratory system -relationship: inheres_in GO:0007585 ! respiratory gaseous exchange by respiratory system +intersection_of: RO:0000052 GO:0007585 ! inheres in respiratory gaseous exchange by respiratory system +relationship: RO:0000052 GO:0007585 ! inheres in respiratory gaseous exchange by respiratory system [Term] id: OBA:1000806 @@ -166963,8 +266318,8 @@ def: "The quality of a myeloblast." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of myeloblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000835 ! myeloblast -relationship: inheres_in CL:0000835 ! myeloblast +intersection_of: RO:0000052 CL:0000835 ! inheres in myeloblast +relationship: RO:0000052 CL:0000835 ! inheres in myeloblast [Term] id: OBA:1000807 @@ -166974,8 +266329,8 @@ synonym: "quality of milk ejection reflex" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0001784 ! fluid regulation trait is_a: OBA:VT0001961 ! reflex trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060156 ! milk ejection reflex -relationship: inheres_in GO:0060156 ! milk ejection reflex +intersection_of: RO:0000052 GO:0060156 ! inheres in milk ejection reflex +relationship: RO:0000052 GO:0060156 ! inheres in milk ejection reflex [Term] id: OBA:1000808 @@ -166984,8 +266339,8 @@ def: "The quality of a midbrain cerebral aqueduct." [AUTO:patterns/patterns/enti synonym: "quality of midbrain cerebral aqueduct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000285 ! brain ventricle quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002289 ! midbrain cerebral aqueduct -relationship: inheres_in UBERON:0002289 ! midbrain cerebral aqueduct +intersection_of: RO:0000052 UBERON:0002289 ! inheres in midbrain cerebral aqueduct +relationship: RO:0000052 UBERON:0002289 ! inheres in midbrain cerebral aqueduct [Term] id: OBA:1000809 @@ -166994,8 +266349,8 @@ def: "The quality of a mating behavior." [AUTO:patterns/patterns/entity_attribut synonym: "quality of mating behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000014 ! mating behavior -relationship: inheres_in NBO:0000014 ! mating behavior +intersection_of: RO:0000052 NBO:0000014 ! inheres in mating behavior +relationship: RO:0000052 NBO:0000014 ! inheres in mating behavior [Term] id: OBA:1000810 @@ -167004,8 +266359,8 @@ def: "The quality of a superior colliculus." [AUTO:patterns/patterns/entity_attr synonym: "quality of superior colliculus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001945 ! superior colliculus -relationship: inheres_in UBERON:0001945 ! superior colliculus +intersection_of: RO:0000052 UBERON:0001945 ! inheres in superior colliculus +relationship: RO:0000052 UBERON:0001945 ! inheres in superior colliculus [Term] id: OBA:1000811 @@ -167014,8 +266369,8 @@ def: "The quality of a monoamine oxidase activity." [AUTO:patterns/patterns/enti synonym: "quality of monoamine oxidase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097621 ! monoamine oxidase activity -relationship: inheres_in GO:0097621 ! monoamine oxidase activity +intersection_of: RO:0000052 GO:0097621 ! inheres in monoamine oxidase activity +relationship: RO:0000052 GO:0097621 ! inheres in monoamine oxidase activity [Term] id: OBA:1000812 @@ -167024,8 +266379,8 @@ def: "The quality of a dermal papilla." [AUTO:patterns/patterns/entity_attribute synonym: "quality of dermal papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000412 ! dermal papilla -relationship: inheres_in UBERON:0000412 ! dermal papilla +intersection_of: RO:0000052 UBERON:0000412 ! inheres in dermal papilla +relationship: RO:0000052 UBERON:0000412 ! inheres in dermal papilla [Term] id: OBA:1000813 @@ -167034,8 +266389,8 @@ def: "The quality of a strand of zigzag hair." [AUTO:patterns/patterns/entity_at synonym: "quality of strand of zigzag hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010513 ! strand of zigzag hair -relationship: inheres_in UBERON:0010513 ! strand of zigzag hair +intersection_of: RO:0000052 UBERON:0010513 ! inheres in strand of zigzag hair +relationship: RO:0000052 UBERON:0010513 ! inheres in strand of zigzag hair [Term] id: OBA:1000814 @@ -167044,18 +266399,13 @@ def: "The quality of a nephron morphogenesis." [AUTO:patterns/patterns/entity_at synonym: "quality of nephron morphogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072028 ! nephron morphogenesis -relationship: inheres_in GO:0072028 ! nephron morphogenesis +intersection_of: RO:0000052 GO:0072028 ! inheres in nephron morphogenesis +relationship: RO:0000052 GO:0072028 ! inheres in nephron morphogenesis [Term] id: OBA:1000815 -name: subarachnoid space development quality -def: "The quality of a subarachnoid space development." [AUTO:patterns/patterns/entity_attribute] -synonym: "quality of subarachnoid space development" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0100002 ! biological process attribute -intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903374 ! subarachnoid space development -relationship: inheres_in GO:1903374 ! subarachnoid space development +comment: Reason for obsoletion: [This term was obsoleted because it does not represent a real process. While subarachnoid space is a valid anatomical structure, it is formed by the development of the structures that surround it.](https://www.ebi.ac.uk/QuickGO/term/GO:1903374) +is_obsolete: true [Term] id: OBA:1000816 @@ -167064,8 +266414,8 @@ def: "The quality of a neuron fate specification." [AUTO:patterns/patterns/entit synonym: "quality of neuron fate specification" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048665 ! neuron fate specification -relationship: inheres_in GO:0048665 ! neuron fate specification +intersection_of: RO:0000052 GO:0048665 ! inheres in neuron fate specification +relationship: RO:0000052 GO:0048665 ! inheres in neuron fate specification [Term] id: OBA:1000817 @@ -167074,8 +266424,8 @@ def: "The quality of a conditioned place preference behavior." [AUTO:patterns/pa synonym: "quality of conditioned place preference behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000222 ! conditioned place preference behavior -relationship: inheres_in NBO:0000222 ! conditioned place preference behavior +intersection_of: RO:0000052 NBO:0000222 ! inheres in conditioned place preference behavior +relationship: RO:0000052 NBO:0000222 ! inheres in conditioned place preference behavior [Term] id: OBA:1000818 @@ -167084,8 +266434,8 @@ def: "The quality of a kidney blood vessel." [AUTO:patterns/patterns/entity_attr synonym: "quality of kidney blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003517 ! kidney blood vessel -relationship: inheres_in UBERON:0003517 ! kidney blood vessel +intersection_of: RO:0000052 UBERON:0003517 ! inheres in kidney blood vessel +relationship: RO:0000052 UBERON:0003517 ! inheres in kidney blood vessel [Term] id: OBA:1000819 @@ -167094,8 +266444,8 @@ def: "The quality of a corneal reflex." [AUTO:patterns/patterns/entity_attribute synonym: "quality of corneal reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000415 ! corneal reflex -relationship: inheres_in NBO:0000415 ! corneal reflex +intersection_of: RO:0000052 NBO:0000415 ! inheres in corneal reflex +relationship: RO:0000052 NBO:0000415 ! inheres in corneal reflex [Term] id: OBA:1000820 @@ -167104,8 +266454,8 @@ def: "The quality of a neural fold elevation formation." [AUTO:patterns/patterns synonym: "quality of neural fold elevation formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021502 ! neural fold elevation formation -relationship: inheres_in GO:0021502 ! neural fold elevation formation +intersection_of: RO:0000052 GO:0021502 ! inheres in neural fold elevation formation +relationship: RO:0000052 GO:0021502 ! inheres in neural fold elevation formation [Term] id: OBA:1000821 @@ -167114,8 +266464,8 @@ def: "The quality of a resting posture." [AUTO:patterns/patterns/entity_attribut synonym: "quality of resting posture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000757 ! posture quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000358 ! resting posture -relationship: inheres_in NBO:0000358 ! resting posture +intersection_of: RO:0000052 NBO:0000358 ! inheres in resting posture +relationship: RO:0000052 NBO:0000358 ! inheres in resting posture [Term] id: OBA:1000822 @@ -167124,8 +266474,8 @@ def: "The quality of a lymph node B cell domain." [AUTO:patterns/patterns/entity synonym: "quality of lymph node B cell domain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010416 ! lymph node B cell domain -relationship: inheres_in UBERON:0010416 ! lymph node B cell domain +intersection_of: RO:0000052 UBERON:0010416 ! inheres in lymph node B cell domain +relationship: RO:0000052 UBERON:0010416 ! inheres in lymph node B cell domain [Term] id: OBA:1000823 @@ -167134,8 +266484,8 @@ def: "The quality of a type I hypersensitivity." [AUTO:patterns/patterns/entity_ synonym: "quality of type I hypersensitivity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010139 ! immune response trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0016068 ! type I hypersensitivity -relationship: inheres_in GO:0016068 ! type I hypersensitivity +intersection_of: RO:0000052 GO:0016068 ! inheres in type I hypersensitivity +relationship: RO:0000052 GO:0016068 ! inheres in type I hypersensitivity [Term] id: OBA:1000824 @@ -167144,8 +266494,8 @@ def: "The quality of a granular layer of cerebellar cortex." [AUTO:patterns/patt synonym: "quality of granular layer of cerebellar cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002956 ! granular layer of cerebellar cortex -relationship: inheres_in UBERON:0002956 ! granular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002956 ! inheres in granular layer of cerebellar cortex +relationship: RO:0000052 UBERON:0002956 ! inheres in granular layer of cerebellar cortex [Term] id: OBA:1000825 @@ -167154,8 +266504,8 @@ def: "The quality of a ovulation from ovarian follicle." [AUTO:patterns/patterns synonym: "quality of ovulation from ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001928 ! ovulation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001542 ! ovulation from ovarian follicle -relationship: inheres_in GO:0001542 ! ovulation from ovarian follicle +intersection_of: RO:0000052 GO:0001542 ! inheres in ovulation from ovarian follicle +relationship: RO:0000052 GO:0001542 ! inheres in ovulation from ovarian follicle [Term] id: OBA:1000826 @@ -167164,8 +266514,8 @@ def: "The quality of a cervical sinus of His." [AUTO:patterns/patterns/entity_at synonym: "quality of cervical sinus of His" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006216 ! cervical sinus of His -relationship: inheres_in UBERON:0006216 ! cervical sinus of His +intersection_of: RO:0000052 UBERON:0006216 ! inheres in cervical sinus of His +relationship: RO:0000052 UBERON:0006216 ! inheres in cervical sinus of His [Term] id: OBA:1000827 @@ -167174,8 +266524,8 @@ def: "The quality of a cerebellum formation." [AUTO:patterns/patterns/entity_att synonym: "quality of cerebellum formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021588 ! cerebellum formation -relationship: inheres_in GO:0021588 ! cerebellum formation +intersection_of: RO:0000052 GO:0021588 ! inheres in cerebellum formation +relationship: RO:0000052 GO:0021588 ! inheres in cerebellum formation [Term] id: OBA:1000828 @@ -167184,8 +266534,8 @@ def: "The quality of a neural fold formation." [AUTO:patterns/patterns/entity_at synonym: "quality of neural fold formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001842 ! neural fold formation -relationship: inheres_in GO:0001842 ! neural fold formation +intersection_of: RO:0000052 GO:0001842 ! inheres in neural fold formation +relationship: RO:0000052 GO:0001842 ! inheres in neural fold formation [Term] id: OBA:1000829 @@ -167194,8 +266544,8 @@ def: "The quality of a thyroid hormone secreting cell." [AUTO:patterns/patterns/ synonym: "quality of thyroid hormone secreting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000452 ! thyroid hormone secreting cell -relationship: inheres_in CL:0000452 ! thyroid hormone secreting cell +intersection_of: RO:0000052 CL:0000452 ! inheres in thyroid hormone secreting cell +relationship: RO:0000052 CL:0000452 ! inheres in thyroid hormone secreting cell [Term] id: OBA:1000830 @@ -167204,8 +266554,8 @@ def: "The quality of a eye blink conditioning behavior." [AUTO:patterns/patterns synonym: "quality of eye blink conditioning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000227 ! eye blink conditioning behavior -relationship: inheres_in NBO:0000227 ! eye blink conditioning behavior +intersection_of: RO:0000052 NBO:0000227 ! inheres in eye blink conditioning behavior +relationship: RO:0000052 NBO:0000227 ! inheres in eye blink conditioning behavior [Term] id: OBA:1000831 @@ -167214,8 +266564,8 @@ def: "The quality of a otolithic part of statoconial membrane." [AUTO:patterns/p synonym: "quality of otolithic part of statoconial membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002519 ! otolithic part of statoconial membrane -relationship: inheres_in UBERON:0002519 ! otolithic part of statoconial membrane +intersection_of: RO:0000052 UBERON:0002519 ! inheres in otolithic part of statoconial membrane +relationship: RO:0000052 UBERON:0002519 ! inheres in otolithic part of statoconial membrane [Term] id: OBA:1000832 @@ -167224,8 +266574,8 @@ def: "The quality of a primary palate." [AUTO:patterns/patterns/entity_attribute synonym: "quality of primary palate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005620 ! primary palate -relationship: inheres_in UBERON:0005620 ! primary palate +intersection_of: RO:0000052 UBERON:0005620 ! inheres in primary palate +relationship: RO:0000052 UBERON:0005620 ! inheres in primary palate [Term] id: OBA:1000833 @@ -167234,8 +266584,8 @@ def: "The quality of a axial mesoderm formation." [AUTO:patterns/patterns/entity synonym: "quality of axial mesoderm formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048320 ! axial mesoderm formation -relationship: inheres_in GO:0048320 ! axial mesoderm formation +intersection_of: RO:0000052 GO:0048320 ! inheres in axial mesoderm formation +relationship: RO:0000052 GO:0048320 ! inheres in axial mesoderm formation [Term] id: OBA:1000834 @@ -167244,8 +266594,8 @@ def: "The quality of a parathyroid gland development." [AUTO:patterns/patterns/e synonym: "quality of parathyroid gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060017 ! parathyroid gland development -relationship: inheres_in GO:0060017 ! parathyroid gland development +intersection_of: RO:0000052 GO:0060017 ! inheres in parathyroid gland development +relationship: RO:0000052 GO:0060017 ! inheres in parathyroid gland development [Term] id: OBA:1000835 @@ -167254,8 +266604,8 @@ def: "The quality of a lateral semicircular canal." [AUTO:patterns/patterns/enti synonym: "quality of lateral semicircular canal" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001843 ! lateral semicircular canal -relationship: inheres_in UBERON:0001843 ! lateral semicircular canal +intersection_of: RO:0000052 UBERON:0001843 ! inheres in lateral semicircular canal +relationship: RO:0000052 UBERON:0001843 ! inheres in lateral semicircular canal [Term] id: OBA:1000836 @@ -167264,8 +266614,8 @@ def: "The quality of a medulla of lymph node." [AUTO:patterns/patterns/entity_at synonym: "quality of medulla of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002007 ! medulla of lymph node -relationship: inheres_in UBERON:0002007 ! medulla of lymph node +intersection_of: RO:0000052 UBERON:0002007 ! inheres in medulla of lymph node +relationship: RO:0000052 UBERON:0002007 ! inheres in medulla of lymph node [Term] id: OBA:1000837 @@ -167274,8 +266624,8 @@ def: "The quality of a righting reflex." [AUTO:patterns/patterns/entity_attribut synonym: "quality of righting reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000871 ! postural reflex quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000578 ! righting reflex -relationship: inheres_in NBO:0000578 ! righting reflex +intersection_of: RO:0000052 NBO:0000578 ! inheres in righting reflex +relationship: RO:0000052 NBO:0000578 ! inheres in righting reflex [Term] id: OBA:1000838 @@ -167284,8 +266634,8 @@ def: "The quality of a thermal nociceptive behavior." [AUTO:patterns/patterns/en synonym: "quality of thermal nociceptive behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000746 ! nociceptive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000335 ! thermal nociceptive behavior -relationship: inheres_in NBO:0000335 ! thermal nociceptive behavior +intersection_of: RO:0000052 NBO:0000335 ! inheres in thermal nociceptive behavior +relationship: RO:0000052 NBO:0000335 ! inheres in thermal nociceptive behavior [Term] id: OBA:1000839 @@ -167294,8 +266644,8 @@ def: "The quality of a vibrissae reflex." [AUTO:patterns/patterns/entity_attribu synonym: "quality of vibrissae reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000583 ! vibrissae reflex -relationship: inheres_in NBO:0000583 ! vibrissae reflex +intersection_of: RO:0000052 NBO:0000583 ! inheres in vibrissae reflex +relationship: RO:0000052 NBO:0000583 ! inheres in vibrissae reflex [Term] id: OBA:1000840 @@ -167304,8 +266654,8 @@ def: "The quality of a alcohol consumption." [AUTO:patterns/patterns/entity_attr synonym: "quality of alcohol consumption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000748 ! feeding behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000131 ! alcohol consumption -relationship: inheres_in NBO:0000131 ! alcohol consumption +intersection_of: RO:0000052 NBO:0000131 ! inheres in alcohol consumption +relationship: RO:0000052 NBO:0000131 ! inheres in alcohol consumption [Term] id: OBA:1000841 @@ -167314,8 +266664,8 @@ def: "The quality of a type II hypersensitivity." [AUTO:patterns/patterns/entity synonym: "quality of type II hypersensitivity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010139 ! immune response trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002445 ! type II hypersensitivity -relationship: inheres_in GO:0002445 ! type II hypersensitivity +intersection_of: RO:0000052 GO:0002445 ! inheres in type II hypersensitivity +relationship: RO:0000052 GO:0002445 ! inheres in type II hypersensitivity [Term] id: OBA:1000842 @@ -167324,8 +266674,8 @@ def: "The quality of a membranous labyrinth." [AUTO:patterns/patterns/entity_att synonym: "quality of membranous labyrinth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001849 ! membranous labyrinth -relationship: inheres_in UBERON:0001849 ! membranous labyrinth +intersection_of: RO:0000052 UBERON:0001849 ! inheres in membranous labyrinth +relationship: RO:0000052 UBERON:0001849 ! inheres in membranous labyrinth [Term] id: OBA:1000843 @@ -167334,18 +266684,18 @@ def: "The quality of a skeletal system development." [AUTO:patterns/patterns/ent synonym: "quality of skeletal system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001501 ! skeletal system development -relationship: inheres_in GO:0001501 ! skeletal system development +intersection_of: RO:0000052 GO:0001501 ! inheres in skeletal system development +relationship: RO:0000052 GO:0001501 ! inheres in skeletal system development [Term] id: OBA:1000844 -name: glomerular visceral epithelial cell quality -def: "The quality of a glomerular visceral epithelial cell." [AUTO:patterns/patterns/entity_attribute] -synonym: "quality of glomerular visceral epithelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] +name: podocyte quality +def: "The quality of a podocyte." [AUTO:patterns/patterns/entity_attribute] +synonym: "quality of podocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000653 ! glomerular visceral epithelial cell -relationship: inheres_in CL:0000653 ! glomerular visceral epithelial cell +intersection_of: RO:0000052 CL:0000653 ! inheres in podocyte +relationship: RO:0000052 CL:0000653 ! inheres in podocyte [Term] id: OBA:1000845 @@ -167354,8 +266704,8 @@ def: "The quality of a avoidance learning behavior." [AUTO:patterns/patterns/ent synonym: "quality of avoidance learning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000210 ! avoidance learning behavior -relationship: inheres_in NBO:0000210 ! avoidance learning behavior +intersection_of: RO:0000052 NBO:0000210 ! inheres in avoidance learning behavior +relationship: RO:0000052 NBO:0000210 ! inheres in avoidance learning behavior [Term] id: OBA:1000846 @@ -167364,8 +266714,8 @@ def: "The quality of a gas homeostasis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of gas homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033483 ! gas homeostasis -relationship: inheres_in GO:0033483 ! gas homeostasis +intersection_of: RO:0000052 GO:0033483 ! inheres in gas homeostasis +relationship: RO:0000052 GO:0033483 ! inheres in gas homeostasis [Term] id: OBA:1000847 @@ -167374,8 +266724,8 @@ def: "The quality of a L-tyrosine aminotransferase activity." [AUTO:patterns/pat synonym: "quality of L-tyrosine aminotransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070547 ! L-tyrosine aminotransferase activity -relationship: inheres_in GO:0070547 ! L-tyrosine aminotransferase activity +intersection_of: RO:0000052 GO:0070547 ! inheres in L-tyrosine aminotransferase activity +relationship: RO:0000052 GO:0070547 ! inheres in L-tyrosine aminotransferase activity [Term] id: OBA:1000848 @@ -167384,8 +266734,8 @@ def: "The quality of a nephrogenic mesenchyme morphogenesis." [AUTO:patterns/pat synonym: "quality of nephrogenic mesenchyme morphogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072134 ! nephrogenic mesenchyme morphogenesis -relationship: inheres_in GO:0072134 ! nephrogenic mesenchyme morphogenesis +intersection_of: RO:0000052 GO:0072134 ! inheres in nephrogenic mesenchyme morphogenesis +relationship: RO:0000052 GO:0072134 ! inheres in nephrogenic mesenchyme morphogenesis [Term] id: OBA:1000849 @@ -167394,8 +266744,8 @@ def: "The quality of a lipoprotein lipase activity." [AUTO:patterns/patterns/ent synonym: "quality of lipoprotein lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000909 ! triglyceride lipase activity quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004465 ! lipoprotein lipase activity -relationship: inheres_in GO:0004465 ! lipoprotein lipase activity +intersection_of: RO:0000052 GO:0004465 ! inheres in lipoprotein lipase activity +relationship: RO:0000052 GO:0004465 ! inheres in lipoprotein lipase activity [Term] id: OBA:1000850 @@ -167404,8 +266754,8 @@ def: "The quality of a nipple sheath formation." [AUTO:patterns/patterns/entity_ synonym: "quality of nipple sheath formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060659 ! nipple sheath formation -relationship: inheres_in GO:0060659 ! nipple sheath formation +intersection_of: RO:0000052 GO:0060659 ! inheres in nipple sheath formation +relationship: RO:0000052 GO:0060659 ! inheres in nipple sheath formation [Term] id: OBA:1000851 @@ -167414,8 +266764,8 @@ def: "The quality of a stria vascularis of cochlear duct." [AUTO:patterns/patter synonym: "quality of stria vascularis of cochlear duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002282 ! stria vascularis of cochlear duct -relationship: inheres_in UBERON:0002282 ! stria vascularis of cochlear duct +intersection_of: RO:0000052 UBERON:0002282 ! inheres in stria vascularis of cochlear duct +relationship: RO:0000052 UBERON:0002282 ! inheres in stria vascularis of cochlear duct [Term] id: OBA:1000852 @@ -167424,8 +266774,8 @@ def: "The quality of a parafollicular cell." [AUTO:patterns/patterns/entity_attr synonym: "quality of parafollicular cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000570 ! parafollicular cell -relationship: inheres_in CL:0000570 ! parafollicular cell +intersection_of: RO:0000052 CL:0000570 ! inheres in parafollicular cell +relationship: RO:0000052 CL:0000570 ! inheres in parafollicular cell [Term] id: OBA:1000853 @@ -167434,8 +266784,8 @@ def: "The quality of a primary sex determination." [AUTO:patterns/patterns/entit synonym: "quality of primary sex determination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002210 ! sex determination trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007538 ! primary sex determination -relationship: inheres_in GO:0007538 ! primary sex determination +intersection_of: RO:0000052 GO:0007538 ! inheres in primary sex determination +relationship: RO:0000052 GO:0007538 ! inheres in primary sex determination [Term] id: OBA:1000854 @@ -167444,8 +266794,8 @@ def: "The quality of a renal filtration." [AUTO:patterns/patterns/entity_attribu synonym: "quality of renal filtration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000505 ! renal system process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097205 ! renal filtration -relationship: inheres_in GO:0097205 ! renal filtration +intersection_of: RO:0000052 GO:0097205 ! inheres in renal filtration +relationship: RO:0000052 GO:0097205 ! inheres in renal filtration [Term] id: OBA:1000855 @@ -167454,8 +266804,8 @@ def: "The quality of a auditory receptor cell development." [AUTO:patterns/patte synonym: "quality of auditory receptor cell development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060117 ! auditory receptor cell development -relationship: inheres_in GO:0060117 ! auditory receptor cell development +intersection_of: RO:0000052 GO:0060117 ! inheres in auditory receptor cell development +relationship: RO:0000052 GO:0060117 ! inheres in auditory receptor cell development [Term] id: OBA:1000856 @@ -167464,8 +266814,8 @@ def: "The quality of a short term spatial memory." [AUTO:patterns/patterns/entit synonym: "quality of short term spatial memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000858 ! spatial memory quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000557 ! short term spatial memory -relationship: inheres_in NBO:0000557 ! short term spatial memory +intersection_of: RO:0000052 NBO:0000557 ! inheres in short term spatial memory +relationship: RO:0000052 NBO:0000557 ! inheres in short term spatial memory [Term] id: OBA:1000857 @@ -167474,8 +266824,8 @@ def: "The quality of a proline oxidase activity." [AUTO:patterns/patterns/entity synonym: "quality of proline oxidase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0051699 ! proline oxidase activity -relationship: inheres_in GO:0051699 ! proline oxidase activity +intersection_of: RO:0000052 GO:0051699 ! inheres in proline oxidase activity +relationship: RO:0000052 GO:0051699 ! inheres in proline oxidase activity [Term] id: OBA:1000858 @@ -167484,8 +266834,8 @@ def: "The quality of a spatial memory." [AUTO:patterns/patterns/entity_attribute synonym: "quality of spatial memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000556 ! spatial memory -relationship: inheres_in NBO:0000556 ! spatial memory +intersection_of: RO:0000052 NBO:0000556 ! inheres in spatial memory +relationship: RO:0000052 NBO:0000556 ! inheres in spatial memory [Term] id: OBA:1000859 @@ -167494,8 +266844,8 @@ def: "The quality of a brood size." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of brood size" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PATO:0000276 ! brood size -relationship: inheres_in PATO:0000276 ! brood size +intersection_of: RO:0000052 PATO:0000276 ! inheres in brood size +relationship: RO:0000052 PATO:0000276 ! inheres in brood size [Term] id: OBA:1000860 @@ -167504,8 +266854,8 @@ def: "The quality of a meiotic spindle assembly checkpoint signaling." [AUTO:pat synonym: "quality of meiotic spindle assembly checkpoint signaling" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033316 ! meiotic spindle assembly checkpoint signaling -relationship: inheres_in GO:0033316 ! meiotic spindle assembly checkpoint signaling +intersection_of: RO:0000052 GO:0033316 ! inheres in meiotic spindle assembly checkpoint signaling +relationship: RO:0000052 GO:0033316 ! inheres in meiotic spindle assembly checkpoint signaling [Term] id: OBA:1000861 @@ -167514,8 +266864,8 @@ def: "The quality of a contextual conditioning behavior." [AUTO:patterns/pattern synonym: "quality of contextual conditioning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000223 ! contextual conditioning behavior -relationship: inheres_in NBO:0000223 ! contextual conditioning behavior +intersection_of: RO:0000052 NBO:0000223 ! inheres in contextual conditioning behavior +relationship: RO:0000052 NBO:0000223 ! inheres in contextual conditioning behavior [Term] id: OBA:1000862 @@ -167524,8 +266874,8 @@ def: "The quality of a visual object recognition." [AUTO:patterns/patterns/entit synonym: "quality of visual object recognition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000551 ! visual object recognition -relationship: inheres_in NBO:0000551 ! visual object recognition +intersection_of: RO:0000052 NBO:0000551 ! inheres in visual object recognition +relationship: RO:0000052 NBO:0000551 ! inheres in visual object recognition [Term] id: OBA:1000863 @@ -167534,8 +266884,8 @@ def: "The quality of a caecum development." [AUTO:patterns/patterns/entity_attri synonym: "quality of caecum development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903700 ! caecum development -relationship: inheres_in GO:1903700 ! caecum development +intersection_of: RO:0000052 GO:1903700 ! inheres in caecum development +relationship: RO:0000052 GO:1903700 ! inheres in caecum development [Term] id: OBA:1000864 @@ -167544,8 +266894,8 @@ def: "The quality of a optic vesicle formation." [AUTO:patterns/patterns/entity_ synonym: "quality of optic vesicle formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003403 ! optic vesicle formation -relationship: inheres_in GO:0003403 ! optic vesicle formation +intersection_of: RO:0000052 GO:0003403 ! inheres in optic vesicle formation +relationship: RO:0000052 GO:0003403 ! inheres in optic vesicle formation [Term] id: OBA:1000865 @@ -167554,8 +266904,8 @@ def: "The quality of a huddling behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of huddling behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000052 ! huddling behavior -relationship: inheres_in NBO:0000052 ! huddling behavior +intersection_of: RO:0000052 NBO:0000052 ! inheres in huddling behavior +relationship: RO:0000052 NBO:0000052 ! inheres in huddling behavior [Term] id: OBA:1000866 @@ -167564,8 +266914,8 @@ def: "The quality of a blood cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of blood cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000081 ! blood cell -relationship: inheres_in CL:0000081 ! blood cell +intersection_of: RO:0000052 CL:0000081 ! inheres in blood cell +relationship: RO:0000052 CL:0000081 ! inheres in blood cell [Term] id: OBA:1000867 @@ -167574,8 +266924,8 @@ def: "The quality of a cortex of hair." [AUTO:patterns/patterns/entity_attribute synonym: "quality of cortex of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002077 ! cortex of hair -relationship: inheres_in UBERON:0002077 ! cortex of hair +intersection_of: RO:0000052 UBERON:0002077 ! inheres in cortex of hair +relationship: RO:0000052 UBERON:0002077 ! inheres in cortex of hair [Term] id: OBA:1000868 @@ -167584,8 +266934,8 @@ def: "The quality of a metestrus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of metestrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060210 ! metestrus -relationship: inheres_in GO:0060210 ! metestrus +intersection_of: RO:0000052 GO:0060210 ! inheres in metestrus +relationship: RO:0000052 GO:0060210 ! inheres in metestrus [Term] id: OBA:1000869 @@ -167594,8 +266944,8 @@ def: "The quality of a gait." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of gait" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000775 ! motor coordination quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000361 ! gait -relationship: inheres_in NBO:0000361 ! gait +intersection_of: RO:0000052 NBO:0000361 ! inheres in gait +relationship: RO:0000052 NBO:0000361 ! inheres in gait [Term] id: OBA:1000870 @@ -167609,8 +266959,8 @@ def: "The quality of a postural reflex." [AUTO:patterns/patterns/entity_attribut synonym: "quality of postural reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000577 ! postural reflex -relationship: inheres_in NBO:0000577 ! postural reflex +intersection_of: RO:0000052 NBO:0000577 ! inheres in postural reflex +relationship: RO:0000052 NBO:0000577 ! inheres in postural reflex [Term] id: OBA:1000872 @@ -167619,8 +266969,8 @@ def: "The quality of a Leydig cell differentiation." [AUTO:patterns/patterns/ent synonym: "quality of Leydig cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033327 ! Leydig cell differentiation -relationship: inheres_in GO:0033327 ! Leydig cell differentiation +intersection_of: RO:0000052 GO:0033327 ! inheres in Leydig cell differentiation +relationship: RO:0000052 GO:0033327 ! inheres in Leydig cell differentiation [Term] id: OBA:1000873 @@ -167634,8 +266984,8 @@ def: "The quality of a passive avoidance learning behavior." [AUTO:patterns/patt synonym: "quality of passive avoidance learning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000845 ! avoidance learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000218 ! passive avoidance learning behavior -relationship: inheres_in NBO:0000218 ! passive avoidance learning behavior +intersection_of: RO:0000052 NBO:0000218 ! inheres in passive avoidance learning behavior +relationship: RO:0000052 NBO:0000218 ! inheres in passive avoidance learning behavior [Term] id: OBA:1000875 @@ -167644,8 +266994,8 @@ def: "The quality of a substantia propria of cornea development." [AUTO:patterns synonym: "quality of substantia propria of cornea development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:1903701 ! substantia propria of cornea development -relationship: inheres_in GO:1903701 ! substantia propria of cornea development +intersection_of: RO:0000052 GO:1903701 ! inheres in substantia propria of cornea development +relationship: RO:0000052 GO:1903701 ! inheres in substantia propria of cornea development [Term] id: OBA:1000876 @@ -167654,8 +267004,8 @@ def: "The quality of a perilymph." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of perilymph" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001845 ! perilymph -relationship: inheres_in UBERON:0001845 ! perilymph +intersection_of: RO:0000052 UBERON:0001845 ! inheres in perilymph +relationship: RO:0000052 UBERON:0001845 ! inheres in perilymph [Term] id: OBA:1000877 @@ -167664,8 +267014,8 @@ def: "The quality of a alveolar process of maxilla." [AUTO:patterns/patterns/ent synonym: "quality of alveolar process of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004527 ! alveolar process of maxilla -relationship: inheres_in UBERON:0004527 ! alveolar process of maxilla +intersection_of: RO:0000052 UBERON:0004527 ! inheres in alveolar process of maxilla +relationship: RO:0000052 UBERON:0004527 ! inheres in alveolar process of maxilla [Term] id: OBA:1000878 @@ -167674,8 +267024,8 @@ def: "The quality of a papilla of tongue." [AUTO:patterns/patterns/entity_attrib synonym: "quality of papilla of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001726 ! papilla of tongue -relationship: inheres_in UBERON:0001726 ! papilla of tongue +intersection_of: RO:0000052 UBERON:0001726 ! inheres in papilla of tongue +relationship: RO:0000052 UBERON:0001726 ! inheres in papilla of tongue [Term] id: OBA:1000879 @@ -167684,8 +267034,8 @@ def: "The quality of a operant conditioning behavior." [AUTO:patterns/patterns/e synonym: "quality of operant conditioning behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000212 ! operant conditioning behavior -relationship: inheres_in NBO:0000212 ! operant conditioning behavior +intersection_of: RO:0000052 NBO:0000212 ! inheres in operant conditioning behavior +relationship: RO:0000052 NBO:0000212 ! inheres in operant conditioning behavior [Term] id: OBA:1000880 @@ -167694,8 +267044,8 @@ def: "The quality of a mesangial matrix." [AUTO:patterns/patterns/entity_attribu synonym: "quality of mesangial matrix" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0012352 ! mesangial matrix -relationship: inheres_in UBERON:0012352 ! mesangial matrix +intersection_of: RO:0000052 UBERON:0012352 ! inheres in mesangial matrix +relationship: RO:0000052 UBERON:0012352 ! inheres in mesangial matrix [Term] id: OBA:1000881 @@ -167704,8 +267054,8 @@ def: "The quality of a strand of duvet hair." [AUTO:patterns/patterns/entity_att synonym: "quality of strand of duvet hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010514 ! strand of duvet hair -relationship: inheres_in UBERON:0010514 ! strand of duvet hair +intersection_of: RO:0000052 UBERON:0010514 ! inheres in strand of duvet hair +relationship: RO:0000052 UBERON:0010514 ! inheres in strand of duvet hair [Term] id: OBA:1000882 @@ -167714,8 +267064,8 @@ def: "The quality of a M band." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of M band" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0031430 ! M band -relationship: inheres_in GO:0031430 ! M band +intersection_of: RO:0000052 GO:0031430 ! inheres in M band +relationship: RO:0000052 GO:0031430 ! inheres in M band [Term] id: OBA:1000883 @@ -167724,8 +267074,8 @@ def: "The quality of a synaptonemal complex." [AUTO:patterns/patterns/entity_att synonym: "quality of synaptonemal complex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0000795 ! synaptonemal complex -relationship: inheres_in GO:0000795 ! synaptonemal complex +intersection_of: RO:0000052 GO:0000795 ! inheres in synaptonemal complex +relationship: RO:0000052 GO:0000795 ! inheres in synaptonemal complex [Term] id: OBA:1000884 @@ -167734,8 +267084,8 @@ def: "The quality of a galactose homeostasis." [AUTO:patterns/patterns/entity_at synonym: "quality of galactose homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033501 ! galactose homeostasis -relationship: inheres_in GO:0033501 ! galactose homeostasis +intersection_of: RO:0000052 GO:0033501 ! inheres in galactose homeostasis +relationship: RO:0000052 GO:0033501 ! inheres in galactose homeostasis [Term] id: OBA:1000885 @@ -167744,8 +267094,8 @@ def: "The quality of a involuntary movement behavior." [AUTO:patterns/patterns/e synonym: "quality of involuntary movement behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000678 ! body part movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000388 ! involuntary movement behavior -relationship: inheres_in NBO:0000388 ! involuntary movement behavior +intersection_of: RO:0000052 NBO:0000388 ! inheres in involuntary movement behavior +relationship: RO:0000052 NBO:0000388 ! inheres in involuntary movement behavior [Term] id: OBA:1000886 @@ -167754,8 +267104,8 @@ def: "The quality of a DN2 thymocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of DN2 thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000418 ! T cell quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000806 ! DN2 thymocyte -relationship: inheres_in CL:0000806 ! DN2 thymocyte +intersection_of: RO:0000052 CL:0000806 ! inheres in DN2 thymocyte +relationship: RO:0000052 CL:0000806 ! inheres in DN2 thymocyte [Term] id: OBA:1000887 @@ -167764,8 +267114,8 @@ def: "The quality of a vestibular aqueduct." [AUTO:patterns/patterns/entity_attr synonym: "quality of vestibular aqueduct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002279 ! vestibular aqueduct -relationship: inheres_in UBERON:0002279 ! vestibular aqueduct +intersection_of: RO:0000052 UBERON:0002279 ! inheres in vestibular aqueduct +relationship: RO:0000052 UBERON:0002279 ! inheres in vestibular aqueduct [Term] id: OBA:1000888 @@ -167774,8 +267124,8 @@ def: "The quality of a glomerular filtration." [AUTO:patterns/patterns/entity_at synonym: "quality of glomerular filtration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000854 ! renal filtration quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003094 ! glomerular filtration -relationship: inheres_in GO:0003094 ! glomerular filtration +intersection_of: RO:0000052 GO:0003094 ! inheres in glomerular filtration +relationship: RO:0000052 GO:0003094 ! inheres in glomerular filtration [Term] id: OBA:1000889 @@ -167784,8 +267134,8 @@ def: "The quality of a urothelium." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of urothelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000365 ! urothelium -relationship: inheres_in UBERON:0000365 ! urothelium +intersection_of: RO:0000052 UBERON:0000365 ! inheres in urothelium +relationship: RO:0000052 UBERON:0000365 ! inheres in urothelium [Term] id: OBA:1000890 @@ -167794,8 +267144,8 @@ def: "The quality of a motor learning." [AUTO:patterns/patterns/entity_attribute synonym: "quality of motor learning" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000647 ! associative learning behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000174 ! motor learning -relationship: inheres_in NBO:0000174 ! motor learning +intersection_of: RO:0000052 NBO:0000174 ! inheres in motor learning +relationship: RO:0000052 NBO:0000174 ! inheres in motor learning [Term] id: OBA:1000891 @@ -167804,8 +267154,8 @@ def: "The quality of a novelty response behavior." [AUTO:patterns/patterns/entit synonym: "quality of novelty response behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000603 ! emotional behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000086 ! novelty response behavior -relationship: inheres_in NBO:0000086 ! novelty response behavior +intersection_of: RO:0000052 NBO:0000086 ! inheres in novelty response behavior +relationship: RO:0000052 NBO:0000086 ! inheres in novelty response behavior [Term] id: OBA:1000892 @@ -167814,8 +267164,8 @@ def: "The quality of a thermoception." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of thermoception" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050955 ! thermoception -relationship: inheres_in GO:0050955 ! thermoception +intersection_of: RO:0000052 GO:0050955 ! inheres in thermoception +relationship: RO:0000052 GO:0050955 ! inheres in thermoception [Term] id: OBA:1000893 @@ -167824,8 +267174,8 @@ def: "The quality of a pilomotor reflex." [AUTO:patterns/patterns/entity_attribu synonym: "quality of pilomotor reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000575 ! pilomotor reflex -relationship: inheres_in NBO:0000575 ! pilomotor reflex +intersection_of: RO:0000052 NBO:0000575 ! inheres in pilomotor reflex +relationship: RO:0000052 NBO:0000575 ! inheres in pilomotor reflex [Term] id: OBA:1000894 @@ -167834,8 +267184,8 @@ def: "The quality of a nicotinamide N-methyltransferase activity." [AUTO:pattern synonym: "quality of nicotinamide N-methyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008112 ! nicotinamide N-methyltransferase activity -relationship: inheres_in GO:0008112 ! nicotinamide N-methyltransferase activity +intersection_of: RO:0000052 GO:0008112 ! inheres in nicotinamide N-methyltransferase activity +relationship: RO:0000052 GO:0008112 ! inheres in nicotinamide N-methyltransferase activity [Term] id: OBA:1000895 @@ -167844,8 +267194,8 @@ def: "The quality of a short-term memory." [AUTO:patterns/patterns/entity_attrib synonym: "quality of short-term memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000180 ! short-term memory -relationship: inheres_in NBO:0000180 ! short-term memory +intersection_of: RO:0000052 NBO:0000180 ! inheres in short-term memory +relationship: RO:0000052 NBO:0000180 ! inheres in short-term memory [Term] id: OBA:1000896 @@ -167854,8 +267204,8 @@ def: "The quality of a Harderian gland development." [AUTO:patterns/patterns/ent synonym: "quality of Harderian gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070384 ! Harderian gland development -relationship: inheres_in GO:0070384 ! Harderian gland development +intersection_of: RO:0000052 GO:0070384 ! inheres in Harderian gland development +relationship: RO:0000052 GO:0070384 ! inheres in Harderian gland development [Term] id: OBA:1000897 @@ -167864,8 +267214,8 @@ def: "The quality of a inferior colliculus." [AUTO:patterns/patterns/entity_attr synonym: "quality of inferior colliculus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001946 ! inferior colliculus -relationship: inheres_in UBERON:0001946 ! inferior colliculus +intersection_of: RO:0000052 UBERON:0001946 ! inheres in inferior colliculus +relationship: RO:0000052 UBERON:0001946 ! inheres in inferior colliculus [Term] id: OBA:1000898 @@ -167874,8 +267224,8 @@ def: "The quality of a phenylalanine decarboxylase activity." [AUTO:patterns/pat synonym: "quality of phenylalanine decarboxylase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050174 ! phenylalanine decarboxylase activity -relationship: inheres_in GO:0050174 ! phenylalanine decarboxylase activity +intersection_of: RO:0000052 GO:0050174 ! inheres in phenylalanine decarboxylase activity +relationship: RO:0000052 GO:0050174 ! inheres in phenylalanine decarboxylase activity [Term] id: OBA:1000899 @@ -167884,8 +267234,8 @@ def: "The quality of a mammary gland branching involved in pregnancy." [AUTO:pat synonym: "quality of mammary gland branching involved in pregnancy" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060745 ! mammary gland branching involved in pregnancy -relationship: inheres_in GO:0060745 ! mammary gland branching involved in pregnancy +intersection_of: RO:0000052 GO:0060745 ! inheres in mammary gland branching involved in pregnancy +relationship: RO:0000052 GO:0060745 ! inheres in mammary gland branching involved in pregnancy [Term] id: OBA:1000900 @@ -167894,8 +267244,8 @@ def: "The quality of a bone resorption." [AUTO:patterns/patterns/entity_attribut synonym: "quality of bone resorption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001764 ! homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045453 ! bone resorption -relationship: inheres_in GO:0045453 ! bone resorption +intersection_of: RO:0000052 GO:0045453 ! inheres in bone resorption +relationship: RO:0000052 GO:0045453 ! inheres in bone resorption [Term] id: OBA:1000901 @@ -167904,8 +267254,8 @@ def: "The quality of a trachea development." [AUTO:patterns/patterns/entity_attr synonym: "quality of trachea development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060438 ! trachea development -relationship: inheres_in GO:0060438 ! trachea development +intersection_of: RO:0000052 GO:0060438 ! inheres in trachea development +relationship: RO:0000052 GO:0060438 ! inheres in trachea development [Term] id: OBA:1000902 @@ -167914,8 +267264,8 @@ def: "The quality of a ovarian cumulus expansion." [AUTO:patterns/patterns/entit synonym: "quality of ovarian cumulus expansion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001550 ! ovarian cumulus expansion -relationship: inheres_in GO:0001550 ! ovarian cumulus expansion +intersection_of: RO:0000052 GO:0001550 ! inheres in ovarian cumulus expansion +relationship: RO:0000052 GO:0001550 ! inheres in ovarian cumulus expansion [Term] id: OBA:1000903 @@ -167924,8 +267274,8 @@ def: "The quality of a hetero-barbering." [AUTO:patterns/patterns/entity_attribu synonym: "quality of hetero-barbering" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000664 ! barbering behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000561 ! hetero-barbering -relationship: inheres_in NBO:0000561 ! hetero-barbering +intersection_of: RO:0000052 NBO:0000561 ! inheres in hetero-barbering +relationship: RO:0000052 NBO:0000561 ! inheres in hetero-barbering [Term] id: OBA:1000904 @@ -167934,8 +267284,8 @@ def: "The quality of a phosphatidylcholine-sterol O-acyltransferase activity." [ synonym: "quality of phosphatidylcholine-sterol O-acyltransferase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004607 ! phosphatidylcholine-sterol O-acyltransferase activity -relationship: inheres_in GO:0004607 ! phosphatidylcholine-sterol O-acyltransferase activity +intersection_of: RO:0000052 GO:0004607 ! inheres in phosphatidylcholine-sterol O-acyltransferase activity +relationship: RO:0000052 GO:0004607 ! inheres in phosphatidylcholine-sterol O-acyltransferase activity [Term] id: OBA:1000905 @@ -167944,8 +267294,8 @@ def: "The quality of a sleeping behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of sleeping behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000369 ! behavior process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000024 ! sleeping behavior -relationship: inheres_in NBO:0000024 ! sleeping behavior +intersection_of: RO:0000052 NBO:0000024 ! inheres in sleeping behavior +relationship: RO:0000052 NBO:0000024 ! inheres in sleeping behavior [Term] id: OBA:1000906 @@ -167954,8 +267304,8 @@ def: "The quality of a ureteric bud invasion." [AUTO:patterns/patterns/entity_at synonym: "quality of ureteric bud invasion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072092 ! ureteric bud invasion -relationship: inheres_in GO:0072092 ! ureteric bud invasion +intersection_of: RO:0000052 GO:0072092 ! inheres in ureteric bud invasion +relationship: RO:0000052 GO:0072092 ! inheres in ureteric bud invasion [Term] id: OBA:1000907 @@ -167964,8 +267314,8 @@ def: "The quality of a melanin biosynthetic process." [AUTO:patterns/patterns/en synonym: "quality of melanin biosynthetic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042438 ! melanin biosynthetic process -relationship: inheres_in GO:0042438 ! melanin biosynthetic process +intersection_of: RO:0000052 GO:0042438 ! inheres in melanin biosynthetic process +relationship: RO:0000052 GO:0042438 ! inheres in melanin biosynthetic process [Term] id: OBA:1000908 @@ -167974,8 +267324,8 @@ def: "The quality of a papillary layer of dermis." [AUTO:patterns/patterns/entit synonym: "quality of papillary layer of dermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001992 ! papillary layer of dermis -relationship: inheres_in UBERON:0001992 ! papillary layer of dermis +intersection_of: RO:0000052 UBERON:0001992 ! inheres in papillary layer of dermis +relationship: RO:0000052 UBERON:0001992 ! inheres in papillary layer of dermis [Term] id: OBA:1000909 @@ -167984,8 +267334,8 @@ def: "The quality of a triglyceride lipase activity." [AUTO:patterns/patterns/en synonym: "quality of triglyceride lipase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005584 ! enzyme/coenzyme activity trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0004806 ! triglyceride lipase activity -relationship: inheres_in GO:0004806 ! triglyceride lipase activity +intersection_of: RO:0000052 GO:0004806 ! inheres in triglyceride lipase activity +relationship: RO:0000052 GO:0004806 ! inheres in triglyceride lipase activity [Term] id: OBA:1000910 @@ -167994,8 +267344,8 @@ def: "The quality of a estrus." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of estrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060209 ! estrus -relationship: inheres_in GO:0060209 ! estrus +intersection_of: RO:0000052 GO:0060209 ! inheres in estrus +relationship: RO:0000052 GO:0060209 ! inheres in estrus [Term] id: OBA:1000911 @@ -168004,8 +267354,8 @@ def: "The quality of a fungiform papilla." [AUTO:patterns/patterns/entity_attrib synonym: "quality of fungiform papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000878 ! papilla of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002448 ! fungiform papilla -relationship: inheres_in UBERON:0002448 ! fungiform papilla +intersection_of: RO:0000052 UBERON:0002448 ! inheres in fungiform papilla +relationship: RO:0000052 UBERON:0002448 ! inheres in fungiform papilla [Term] id: OBA:1000912 @@ -168015,8 +267365,8 @@ synonym: "quality of circadian temperature homeostasis" EXACT [AUTO:patterns/pat is_a: OBA:1000369 ! behavior process quality is_a: OBA:VT0010455 ! rhythmic behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000538 ! circadian temperature homeostasis -relationship: inheres_in NBO:0000538 ! circadian temperature homeostasis +intersection_of: RO:0000052 NBO:0000538 ! inheres in circadian temperature homeostasis +relationship: RO:0000052 NBO:0000538 ! inheres in circadian temperature homeostasis [Term] id: OBA:1000913 @@ -168025,8 +267375,8 @@ def: "The quality of a vasculogenesis." [AUTO:patterns/patterns/entity_attribute synonym: "quality of vasculogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001570 ! vasculogenesis -relationship: inheres_in GO:0001570 ! vasculogenesis +intersection_of: RO:0000052 GO:0001570 ! inheres in vasculogenesis +relationship: RO:0000052 GO:0001570 ! inheres in vasculogenesis [Term] id: OBA:1000914 @@ -168035,8 +267385,8 @@ def: "The quality of a hippocampus fimbria." [AUTO:patterns/patterns/entity_attr synonym: "quality of hippocampus fimbria" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002310 ! hippocampus fimbria -relationship: inheres_in UBERON:0002310 ! hippocampus fimbria +intersection_of: RO:0000052 UBERON:0002310 ! inheres in hippocampus fimbria +relationship: RO:0000052 UBERON:0002310 ! inheres in hippocampus fimbria [Term] id: OBA:1000915 @@ -168045,8 +267395,8 @@ def: "The quality of a lacrimal gland development." [AUTO:patterns/patterns/enti synonym: "quality of lacrimal gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032808 ! lacrimal gland development -relationship: inheres_in GO:0032808 ! lacrimal gland development +intersection_of: RO:0000052 GO:0032808 ! inheres in lacrimal gland development +relationship: RO:0000052 GO:0032808 ! inheres in lacrimal gland development [Term] id: OBA:1000916 @@ -168055,8 +267405,8 @@ def: "The quality of a mandibular symphysis." [AUTO:patterns/patterns/entity_att synonym: "quality of mandibular symphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0006606 ! mandibular symphysis -relationship: inheres_in UBERON:0006606 ! mandibular symphysis +intersection_of: RO:0000052 UBERON:0006606 ! inheres in mandibular symphysis +relationship: RO:0000052 UBERON:0006606 ! inheres in mandibular symphysis [Term] id: OBA:1000917 @@ -168065,8 +267415,8 @@ def: "The quality of a photoreceptor inner segment." [AUTO:patterns/patterns/ent synonym: "quality of photoreceptor inner segment" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100001 ! cellular component attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment -relationship: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment +relationship: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:1000918 @@ -168075,8 +267425,8 @@ def: "The quality of a startle reflex." [AUTO:patterns/patterns/entity_attribute synonym: "quality of startle reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000741 ! reflexive behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000391 ! startle reflex -relationship: inheres_in NBO:0000391 ! startle reflex +intersection_of: RO:0000052 NBO:0000391 ! inheres in startle reflex +relationship: RO:0000052 NBO:0000391 ! inheres in startle reflex [Term] id: OBA:1000919 @@ -168085,8 +267435,8 @@ def: "The quality of a chewing." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of chewing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000678 ! body part movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000073 ! chewing -relationship: inheres_in NBO:0000073 ! chewing +intersection_of: RO:0000052 NBO:0000073 ! inheres in chewing +relationship: RO:0000052 NBO:0000073 ! inheres in chewing [Term] id: OBA:1000920 @@ -168095,8 +267445,8 @@ def: "The quality of a ureteric bud elongation." [AUTO:patterns/patterns/entity_ synonym: "quality of ureteric bud elongation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060677 ! ureteric bud elongation -relationship: inheres_in GO:0060677 ! ureteric bud elongation +intersection_of: RO:0000052 GO:0060677 ! inheres in ureteric bud elongation +relationship: RO:0000052 GO:0060677 ! inheres in ureteric bud elongation [Term] id: OBA:1000921 @@ -168105,8 +267455,8 @@ def: "The quality of a filiform papilla." [AUTO:patterns/patterns/entity_attribu synonym: "quality of filiform papilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000878 ! papilla of tongue quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002467 ! filiform papilla -relationship: inheres_in UBERON:0002467 ! filiform papilla +intersection_of: RO:0000052 UBERON:0002467 ! inheres in filiform papilla +relationship: RO:0000052 UBERON:0002467 ! inheres in filiform papilla [Term] id: OBA:1000922 @@ -168115,8 +267465,8 @@ def: "The quality of a granule cell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of granule cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in CL:0000120 ! granule cell -relationship: inheres_in CL:0000120 ! granule cell +intersection_of: RO:0000052 CL:0000120 ! inheres in granule cell +relationship: RO:0000052 CL:0000120 ! inheres in granule cell [Term] id: OBA:1000923 @@ -168125,8 +267475,8 @@ def: "The quality of a offspring retrieval." [AUTO:patterns/patterns/entity_attr synonym: "quality of offspring retrieval" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000155 ! offspring retrieval -relationship: inheres_in NBO:0000155 ! offspring retrieval +intersection_of: RO:0000052 NBO:0000155 ! inheres in offspring retrieval +relationship: RO:0000052 NBO:0000155 ! inheres in offspring retrieval [Term] id: OBA:1000924 @@ -168135,8 +267485,8 @@ def: "The quality of a tail movement." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of tail movement" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000678 ! body part movement quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000445 ! tail movement -relationship: inheres_in NBO:0000445 ! tail movement +intersection_of: RO:0000052 NBO:0000445 ! inheres in tail movement +relationship: RO:0000052 NBO:0000445 ! inheres in tail movement [Term] id: OBA:1000925 @@ -168145,8 +267495,8 @@ def: "The quality of a angiogenesis involved in wound healing." [AUTO:patterns/p synonym: "quality of angiogenesis involved in wound healing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060055 ! angiogenesis involved in wound healing -relationship: inheres_in GO:0060055 ! angiogenesis involved in wound healing +intersection_of: RO:0000052 GO:0060055 ! inheres in angiogenesis involved in wound healing +relationship: RO:0000052 GO:0060055 ! inheres in angiogenesis involved in wound healing [Term] id: OBA:1000926 @@ -168155,8 +267505,8 @@ def: "The quality of a acetylcholinesterase activity." [AUTO:patterns/patterns/e synonym: "quality of acetylcholinesterase activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000658 ! cholinesterase activity quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003990 ! acetylcholinesterase activity -relationship: inheres_in GO:0003990 ! acetylcholinesterase activity +intersection_of: RO:0000052 GO:0003990 ! inheres in acetylcholinesterase activity +relationship: RO:0000052 GO:0003990 ! inheres in acetylcholinesterase activity [Term] id: OBA:1000927 @@ -168165,8 +267515,8 @@ def: "The quality of a ovarian follicle." [AUTO:patterns/patterns/entity_attribu synonym: "quality of ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001305 ! ovarian follicle -relationship: inheres_in UBERON:0001305 ! ovarian follicle +intersection_of: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle +relationship: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle [Term] id: OBA:1000928 @@ -168175,8 +267525,8 @@ def: "The quality of a social investigation." [AUTO:patterns/patterns/entity_att synonym: "quality of social investigation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000407 ! social behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000148 ! social investigation -relationship: inheres_in NBO:0000148 ! social investigation +intersection_of: RO:0000052 NBO:0000148 ! inheres in social investigation +relationship: RO:0000052 NBO:0000148 ! inheres in social investigation [Term] id: OBA:1000929 @@ -168185,8 +267535,8 @@ def: "The quality of a optic disc." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of optic disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001783 ! optic disc -relationship: inheres_in UBERON:0001783 ! optic disc +intersection_of: RO:0000052 UBERON:0001783 ! inheres in optic disc +relationship: RO:0000052 UBERON:0001783 ! inheres in optic disc [Term] id: OBA:1000930 @@ -168195,8 +267545,8 @@ def: "The quality of a juxtaglomerular apparatus." [AUTO:patterns/patterns/entit synonym: "quality of juxtaglomerular apparatus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002303 ! juxtaglomerular apparatus -relationship: inheres_in UBERON:0002303 ! juxtaglomerular apparatus +intersection_of: RO:0000052 UBERON:0002303 ! inheres in juxtaglomerular apparatus +relationship: RO:0000052 UBERON:0002303 ! inheres in juxtaglomerular apparatus [Term] id: OBA:1000931 @@ -168205,8 +267555,8 @@ def: "The quality of a sensory perception of sound." [AUTO:patterns/patterns/ent synonym: "quality of sensory perception of sound" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007605 ! sensory perception of sound -relationship: inheres_in GO:0007605 ! sensory perception of sound +intersection_of: RO:0000052 GO:0007605 ! inheres in sensory perception of sound +relationship: RO:0000052 GO:0007605 ! inheres in sensory perception of sound [Term] id: OBA:1000932 @@ -168215,8 +267565,8 @@ def: "The quality of a cuticle of hair." [AUTO:patterns/patterns/entity_attribut synonym: "quality of cuticle of hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002076 ! cuticle of hair -relationship: inheres_in UBERON:0002076 ! cuticle of hair +intersection_of: RO:0000052 UBERON:0002076 ! inheres in cuticle of hair +relationship: RO:0000052 UBERON:0002076 ! inheres in cuticle of hair [Term] id: OBA:1000933 @@ -168225,8 +267575,8 @@ def: "The quality of a short term object recognition memory." [AUTO:patterns/pat synonym: "quality of short term object recognition memory" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000895 ! short-term memory quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000553 ! short term object recognition memory -relationship: inheres_in NBO:0000553 ! short term object recognition memory +intersection_of: RO:0000052 NBO:0000553 ! inheres in short term object recognition memory +relationship: RO:0000052 NBO:0000553 ! inheres in short term object recognition memory [Term] id: OBA:1000934 @@ -168235,8 +267585,8 @@ def: "The quality of a strand of guard hair." [AUTO:patterns/patterns/entity_att synonym: "quality of strand of guard hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0010512 ! strand of guard hair -relationship: inheres_in UBERON:0010512 ! strand of guard hair +intersection_of: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair +relationship: RO:0000052 UBERON:0010512 ! inheres in strand of guard hair [Term] id: OBA:1000935 @@ -168245,8 +267595,8 @@ def: "The quality of a response to novel odor." [AUTO:patterns/patterns/entity_a synonym: "quality of response to novel odor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000891 ! novelty response behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000099 ! response to novel odor -relationship: inheres_in NBO:0000099 ! response to novel odor +intersection_of: RO:0000052 NBO:0000099 ! inheres in response to novel odor +relationship: RO:0000052 NBO:0000099 ! inheres in response to novel odor [Term] id: OBA:1000936 @@ -168255,8 +267605,8 @@ def: "The quality of a cloacal septation." [AUTO:patterns/patterns/entity_attrib synonym: "quality of cloacal septation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060197 ! cloacal septation -relationship: inheres_in GO:0060197 ! cloacal septation +intersection_of: RO:0000052 GO:0060197 ! inheres in cloacal septation +relationship: RO:0000052 GO:0060197 ! inheres in cloacal septation [Term] id: OBA:1000937 @@ -168265,8 +267615,8 @@ def: "The quality of a fear-related behavior." [AUTO:patterns/patterns/entity_at synonym: "quality of fear-related behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000225 ! fear/anxiety related behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000091 ! fear-related behavior -relationship: inheres_in NBO:0000091 ! fear-related behavior +intersection_of: RO:0000052 NBO:0000091 ! inheres in fear-related behavior +relationship: RO:0000052 NBO:0000091 ! inheres in fear-related behavior [Term] id: OBA:1000938 @@ -168275,8 +267625,8 @@ def: "The quality of a touch related behavior." [AUTO:patterns/patterns/entity_a synonym: "quality of touch related behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000713 ! cutaneous sensation behavior quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in NBO:0000332 ! touch related behavior -relationship: inheres_in NBO:0000332 ! touch related behavior +intersection_of: RO:0000052 NBO:0000332 ! inheres in touch related behavior +relationship: RO:0000052 NBO:0000332 ! inheres in touch related behavior [Term] id: OBA:1000939 @@ -168285,19 +267635,18 @@ def: "The quality of a otic vesicle formation." [AUTO:patterns/patterns/entity_a synonym: "quality of otic vesicle formation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030916 ! otic vesicle formation -relationship: inheres_in GO:0030916 ! otic vesicle formation +intersection_of: RO:0000052 GO:0030916 ! inheres in otic vesicle formation +relationship: RO:0000052 GO:0030916 ! inheres in otic vesicle formation [Term] id: OBA:1000940 name: monoatomic ion amount def: "The amount of a monoatomic ion." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of monoatomic ion" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0100004 ! chemical entity attribute -is_a: PATO:0000070 ! amount +is_a: OBA:VT0000192 ! mineral amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:24867 ! monoatomic ion -relationship: inheres_in CHEBI:24867 ! monoatomic ion +intersection_of: RO:0000052 CHEBI:24867 ! inheres in monoatomic ion +relationship: RO:0000052 CHEBI:24867 ! inheres in monoatomic ion [Term] id: OBA:1000941 @@ -168306,8 +267655,8 @@ def: "The amount of a insulin gene translation product." [AUTO:patterns/patterns synonym: "amount of insulin gene translation product" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000009054 ! insulin gene translation product -relationship: inheres_in PR:000009054 ! insulin gene translation product +intersection_of: RO:0000052 PR:000009054 ! inheres in insulin gene translation product +relationship: RO:0000052 PR:000009054 ! inheres in insulin gene translation product [Term] id: OBA:1000942 @@ -168316,8 +267665,8 @@ def: "The amount of a alpha-fetoprotein." [AUTO:patterns/patterns/entity_attribu synonym: "amount of alpha-fetoprotein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000003809 ! alpha-fetoprotein -relationship: inheres_in PR:000003809 ! alpha-fetoprotein +intersection_of: RO:0000052 PR:000003809 ! inheres in alpha-fetoprotein +relationship: RO:0000052 PR:000003809 ! inheres in alpha-fetoprotein [Term] id: OBA:1000943 @@ -168326,8 +267675,8 @@ def: "The amount of a copper atom." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of copper atom" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000182 ! nutrient level intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:28694 ! copper atom -relationship: inheres_in CHEBI:28694 ! copper atom +intersection_of: RO:0000052 CHEBI:28694 ! inheres in copper atom +relationship: RO:0000052 CHEBI:28694 ! inheres in copper atom [Term] id: OBA:1000944 @@ -168336,8 +267685,8 @@ def: "The amount of a neopterins." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of neopterins" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:25500 ! neopterins -relationship: inheres_in CHEBI:25500 ! neopterins +intersection_of: RO:0000052 CHEBI:25500 ! inheres in neopterins +relationship: RO:0000052 CHEBI:25500 ! inheres in neopterins [Term] id: OBA:1000945 @@ -168346,8 +267695,8 @@ def: "The amount of a biopterins." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of biopterins" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:22881 ! biopterins -relationship: inheres_in CHEBI:22881 ! biopterins +intersection_of: RO:0000052 CHEBI:22881 ! inheres in biopterins +relationship: RO:0000052 CHEBI:22881 ! inheres in biopterins [Term] id: OBA:1000946 @@ -168356,8 +267705,8 @@ def: "The amount of a iron cation." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of iron cation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000940 ! monoatomic ion amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:24875 ! iron cation -relationship: inheres_in CHEBI:24875 ! iron cation +intersection_of: RO:0000052 CHEBI:24875 ! inheres in iron cation +relationship: RO:0000052 CHEBI:24875 ! inheres in iron cation [Term] id: OBA:1000947 @@ -168367,8 +267716,8 @@ synonym: "amount of nitrogen molecular entity" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:51143 ! nitrogen molecular entity -relationship: inheres_in CHEBI:51143 ! nitrogen molecular entity +intersection_of: RO:0000052 CHEBI:51143 ! inheres in nitrogen molecular entity +relationship: RO:0000052 CHEBI:51143 ! inheres in nitrogen molecular entity [Term] id: OBA:1000948 @@ -168377,8 +267726,8 @@ def: "The amount of a potassium(1+)." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of potassium(1+)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000940 ! monoatomic ion amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:29103 ! potassium(1+) -relationship: inheres_in CHEBI:29103 ! potassium(1+) +intersection_of: RO:0000052 CHEBI:29103 ! inheres in potassium(1+) +relationship: RO:0000052 CHEBI:29103 ! inheres in potassium(1+) [Term] id: OBA:1000949 @@ -168387,8 +267736,8 @@ def: "The amount of a sodium(1+)." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of sodium(1+)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000940 ! monoatomic ion amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:29101 ! sodium(1+) -relationship: inheres_in CHEBI:29101 ! sodium(1+) +intersection_of: RO:0000052 CHEBI:29101 ! inheres in sodium(1+) +relationship: RO:0000052 CHEBI:29101 ! inheres in sodium(1+) [Term] id: OBA:1000950 @@ -168398,8 +267747,8 @@ synonym: "amount of sulfoglycosphingolipid" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000974 ! acidic glycosphingolipid amount is_a: OBA:1000997 ! sulfolipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:36477 ! sulfoglycosphingolipid -relationship: inheres_in CHEBI:36477 ! sulfoglycosphingolipid +intersection_of: RO:0000052 CHEBI:36477 ! inheres in sulfoglycosphingolipid +relationship: RO:0000052 CHEBI:36477 ! inheres in sulfoglycosphingolipid [Term] id: OBA:1000951 @@ -168408,8 +267757,8 @@ def: "The amount of a ceramide." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of ceramide" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000965 ! sphingolipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17761 ! ceramide -relationship: inheres_in CHEBI:17761 ! ceramide +intersection_of: RO:0000052 CHEBI:17761 ! inheres in ceramide +relationship: RO:0000052 CHEBI:17761 ! inheres in ceramide [Term] id: OBA:1000952 @@ -168418,8 +267767,8 @@ def: "The amount of a prolactin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of prolactin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000013246 ! prolactin -relationship: inheres_in PR:000013246 ! prolactin +intersection_of: RO:0000052 PR:000013246 ! inheres in prolactin +relationship: RO:0000052 PR:000013246 ! inheres in prolactin [Term] id: OBA:1000953 @@ -168428,8 +267777,8 @@ def: "The amount of a bradykinin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of bradykinin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:3165 ! bradykinin -relationship: inheres_in CHEBI:3165 ! bradykinin +intersection_of: RO:0000052 CHEBI:3165 ! inheres in bradykinin +relationship: RO:0000052 CHEBI:3165 ! inheres in bradykinin [Term] id: OBA:1000954 @@ -168438,18 +267787,18 @@ def: "The amount of a proline." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of proline" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001001 ! amino acid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26271 ! proline -relationship: inheres_in CHEBI:26271 ! proline +intersection_of: RO:0000052 CHEBI:26271 ! inheres in proline +relationship: RO:0000052 CHEBI:26271 ! inheres in proline [Term] id: OBA:1000955 name: vitamin E amount def: "The amount of a vitamin E." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of vitamin E" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:33234 ! vitamin E -relationship: inheres_in CHEBI:33234 ! vitamin E +intersection_of: RO:0000052 CHEBI:33234 ! inheres in vitamin E +relationship: RO:0000052 CHEBI:33234 ! inheres in vitamin E [Term] id: OBA:1000956 @@ -168458,8 +267807,8 @@ def: "The amount of a somatostatin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of somatostatin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000015665 ! somatostatin -relationship: inheres_in PR:000015665 ! somatostatin +intersection_of: RO:0000052 PR:000015665 ! inheres in somatostatin +relationship: RO:0000052 PR:000015665 ! inheres in somatostatin [Term] id: OBA:1000957 @@ -168469,8 +267818,8 @@ synonym: "amount of carbon dioxide" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16526 ! carbon dioxide -relationship: inheres_in CHEBI:16526 ! carbon dioxide +intersection_of: RO:0000052 CHEBI:16526 ! inheres in carbon dioxide +relationship: RO:0000052 CHEBI:16526 ! inheres in carbon dioxide [Term] id: OBA:1000958 @@ -168479,8 +267828,8 @@ def: "The amount of a adrenaline." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of adrenaline" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000984 ! catecholamine amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:33568 ! adrenaline -relationship: inheres_in CHEBI:33568 ! adrenaline +intersection_of: RO:0000052 CHEBI:33568 ! inheres in adrenaline +relationship: RO:0000052 CHEBI:33568 ! inheres in adrenaline [Term] id: OBA:1000959 @@ -168489,8 +267838,8 @@ def: "The amount of a chloride." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of chloride" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000940 ! monoatomic ion amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17996 ! chloride -relationship: inheres_in CHEBI:17996 ! chloride +intersection_of: RO:0000052 CHEBI:17996 ! inheres in chloride +relationship: RO:0000052 CHEBI:17996 ! inheres in chloride [Term] id: OBA:1000960 @@ -168500,8 +267849,8 @@ synonym: "amount of 3,3',5-triiodo-L-thyronine" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000972 ! thyroid hormone amount is_a: OBA:1001001 ! amino acid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:18258 ! 3,3',5-triiodo-L-thyronine -relationship: inheres_in CHEBI:18258 ! 3,3',5-triiodo-L-thyronine +intersection_of: RO:0000052 CHEBI:18258 ! inheres in 3,3',5-triiodo-L-thyronine +relationship: RO:0000052 CHEBI:18258 ! inheres in 3,3',5-triiodo-L-thyronine [Term] id: OBA:1000961 @@ -168510,8 +267859,8 @@ def: "The amount of a ether lipid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of ether lipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:64611 ! ether lipid -relationship: inheres_in CHEBI:64611 ! ether lipid +intersection_of: RO:0000052 CHEBI:64611 ! inheres in ether lipid +relationship: RO:0000052 CHEBI:64611 ! inheres in ether lipid [Term] id: OBA:1000962 @@ -168520,8 +267869,8 @@ def: "The amount of a biopterin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of biopterin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000945 ! biopterins amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:15373 ! biopterin -relationship: inheres_in CHEBI:15373 ! biopterin +intersection_of: RO:0000052 CHEBI:15373 ! inheres in biopterin +relationship: RO:0000052 CHEBI:15373 ! inheres in biopterin [Term] id: OBA:1000963 @@ -168530,8 +267879,8 @@ def: "The amount of a prostaglandin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of prostaglandin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26333 ! prostaglandin -relationship: inheres_in CHEBI:26333 ! prostaglandin +intersection_of: RO:0000052 CHEBI:26333 ! inheres in prostaglandin +relationship: RO:0000052 CHEBI:26333 ! inheres in prostaglandin [Term] id: OBA:1000964 @@ -168541,8 +267890,8 @@ synonym: "amount of testosterone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000079 ! hormone levels is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17347 ! testosterone -relationship: inheres_in CHEBI:17347 ! testosterone +intersection_of: RO:0000052 CHEBI:17347 ! inheres in testosterone +relationship: RO:0000052 CHEBI:17347 ! inheres in testosterone [Term] id: OBA:1000965 @@ -168552,8 +267901,8 @@ synonym: "amount of sphingolipid" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000947 ! nitrogen molecular entity amount is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26739 ! sphingolipid -relationship: inheres_in CHEBI:26739 ! sphingolipid +intersection_of: RO:0000052 CHEBI:26739 ! inheres in sphingolipid +relationship: RO:0000052 CHEBI:26739 ! inheres in sphingolipid [Term] id: OBA:1000966 @@ -168563,8 +267912,8 @@ synonym: "amount of glycerol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17754 ! glycerol -relationship: inheres_in CHEBI:17754 ! glycerol +intersection_of: RO:0000052 CHEBI:17754 ! inheres in glycerol +relationship: RO:0000052 CHEBI:17754 ! inheres in glycerol [Term] id: OBA:1000967 @@ -168573,19 +267922,19 @@ def: "The amount of a adiponectin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of adiponectin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000003777 ! adiponectin -relationship: inheres_in PR:000003777 ! adiponectin +intersection_of: RO:0000052 PR:000003777 ! inheres in adiponectin +relationship: RO:0000052 PR:000003777 ! inheres in adiponectin [Term] id: OBA:1000968 name: vitamin D amount def: "The amount of a vitamin D." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of vitamin D" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:27300 ! vitamin D -relationship: inheres_in CHEBI:27300 ! vitamin D +intersection_of: RO:0000052 CHEBI:27300 ! inheres in vitamin D +relationship: RO:0000052 CHEBI:27300 ! inheres in vitamin D [Term] id: OBA:1000969 @@ -168594,8 +267943,8 @@ def: "The amount of a insulin-like growth factor I." [AUTO:patterns/patterns/ent synonym: "amount of insulin-like growth factor I" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000009182 ! insulin-like growth factor I -relationship: inheres_in PR:000009182 ! insulin-like growth factor I +intersection_of: RO:0000052 PR:000009182 ! inheres in insulin-like growth factor I +relationship: RO:0000052 PR:000009182 ! inheres in insulin-like growth factor I [Term] id: OBA:1000970 @@ -168604,8 +267953,8 @@ def: "The amount of a sphingosine." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of sphingosine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000965 ! sphingolipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16393 ! sphingosine -relationship: inheres_in CHEBI:16393 ! sphingosine +intersection_of: RO:0000052 CHEBI:16393 ! inheres in sphingosine +relationship: RO:0000052 CHEBI:16393 ! inheres in sphingosine [Term] id: OBA:1000971 @@ -168614,8 +267963,8 @@ def: "The amount of a glycosaminoglycan." [AUTO:patterns/patterns/entity_attribu synonym: "amount of glycosaminoglycan" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:18085 ! glycosaminoglycan -relationship: inheres_in CHEBI:18085 ! glycosaminoglycan +intersection_of: RO:0000052 CHEBI:18085 ! inheres in glycosaminoglycan +relationship: RO:0000052 CHEBI:18085 ! inheres in glycosaminoglycan [Term] id: OBA:1000972 @@ -168631,8 +267980,8 @@ def: "The amount of a sterol." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of sterol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:15889 ! sterol -relationship: inheres_in CHEBI:15889 ! sterol +intersection_of: RO:0000052 CHEBI:15889 ! inheres in sterol +relationship: RO:0000052 CHEBI:15889 ! inheres in sterol [Term] id: OBA:1000974 @@ -168641,18 +267990,18 @@ def: "The amount of a acidic glycosphingolipid." [AUTO:patterns/patterns/entity_ synonym: "amount of acidic glycosphingolipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000987 ! glycosphingolipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:36526 ! acidic glycosphingolipid -relationship: inheres_in CHEBI:36526 ! acidic glycosphingolipid +intersection_of: RO:0000052 CHEBI:36526 ! inheres in acidic glycosphingolipid +relationship: RO:0000052 CHEBI:36526 ! inheres in acidic glycosphingolipid [Term] id: OBA:1000975 name: L-ascorbic acid amount def: "The amount of a L-ascorbic acid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of L-ascorbic acid" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:29073 ! L-ascorbic acid -relationship: inheres_in CHEBI:29073 ! L-ascorbic acid +intersection_of: RO:0000052 CHEBI:29073 ! inheres in L-ascorbic acid +relationship: RO:0000052 CHEBI:29073 ! inheres in L-ascorbic acid [Term] id: OBA:1000976 @@ -168661,8 +268010,8 @@ def: "The amount of a fat-soluble vitamin (role)." [AUTO:patterns/patterns/entit synonym: "amount of fat-soluble vitamin (role)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:24020 ! fat-soluble vitamin (role) -relationship: inheres_in CHEBI:24020 ! fat-soluble vitamin (role) +intersection_of: RO:0000052 CHEBI:24020 ! inheres in fat-soluble vitamin (role) +relationship: RO:0000052 CHEBI:24020 ! inheres in fat-soluble vitamin (role) [Term] id: OBA:1000977 @@ -168672,8 +268021,8 @@ synonym: "amount of serotonin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount is_a: OBA:1000993 ! neurotransmitter amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:28790 ! serotonin -relationship: inheres_in CHEBI:28790 ! serotonin +intersection_of: RO:0000052 CHEBI:28790 ! inheres in serotonin +relationship: RO:0000052 CHEBI:28790 ! inheres in serotonin [Term] id: OBA:1000978 @@ -168682,8 +268031,8 @@ def: "The amount of a TGF-beta." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of TGF-beta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000000046 ! TGF-beta -relationship: inheres_in PR:000000046 ! TGF-beta +intersection_of: RO:0000052 PR:000000046 ! inheres in TGF-beta +relationship: RO:0000052 PR:000000046 ! inheres in TGF-beta [Term] id: OBA:1000979 @@ -168693,8 +268042,8 @@ synonym: "amount of radial glial cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000236 ! glial cell quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000681 ! radial glial cell -relationship: inheres_in CL:0000681 ! radial glial cell +intersection_of: RO:0000052 CL:0000681 ! inheres in radial glial cell +relationship: RO:0000052 CL:0000681 ! inheres in radial glial cell [Term] id: OBA:1000980 @@ -168703,8 +268052,8 @@ def: "The amount of a leukotriene." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of leukotriene" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:25029 ! leukotriene -relationship: inheres_in CHEBI:25029 ! leukotriene +intersection_of: RO:0000052 CHEBI:25029 ! inheres in leukotriene +relationship: RO:0000052 CHEBI:25029 ! inheres in leukotriene [Term] id: OBA:1000981 @@ -168713,14 +268062,14 @@ def: "The amount of a oxygen atom." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of oxygen atom" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000182 ! nutrient level intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:25805 ! oxygen atom -relationship: inheres_in CHEBI:25805 ! oxygen atom +intersection_of: RO:0000052 CHEBI:25805 ! inheres in oxygen atom +relationship: RO:0000052 CHEBI:25805 ! inheres in oxygen atom [Term] id: OBA:1000982 -name: vitamin (role) amount -def: "The amount of vitamin (role)." [AUTO:patterns/patterns/chemical_role_attribute] -synonym: "amount of vitamin (role)" EXACT [AUTO:patterns/patterns/chemical_role_attribute] +name: vitamin amount +def: "The amount of vitamin." [AUTO:patterns/patterns/chemical_role_attribute] +synonym: "amount of vitamin" EXACT [AUTO:patterns/patterns/chemical_role_attribute] is_a: OBA:0000182 ! nutrient level [Term] @@ -168730,8 +268079,8 @@ def: "The amount of a thyroid stimulating hormone." [AUTO:patterns/patterns/enti synonym: "amount of thyroid stimulating hormone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:81567 ! thyroid stimulating hormone -relationship: inheres_in CHEBI:81567 ! thyroid stimulating hormone +intersection_of: RO:0000052 CHEBI:81567 ! inheres in thyroid stimulating hormone +relationship: RO:0000052 CHEBI:81567 ! inheres in thyroid stimulating hormone [Term] id: OBA:1000984 @@ -168740,8 +268089,8 @@ def: "The amount of a catecholamine." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of catecholamine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:33567 ! catecholamine -relationship: inheres_in CHEBI:33567 ! catecholamine +intersection_of: RO:0000052 CHEBI:33567 ! inheres in catecholamine +relationship: RO:0000052 CHEBI:33567 ! inheres in catecholamine [Term] id: OBA:1000985 @@ -168750,8 +268099,8 @@ def: "The amount of a noradrenaline." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of noradrenaline" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000984 ! catecholamine amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:33569 ! noradrenaline -relationship: inheres_in CHEBI:33569 ! noradrenaline +intersection_of: RO:0000052 CHEBI:33569 ! inheres in noradrenaline +relationship: RO:0000052 CHEBI:33569 ! inheres in noradrenaline [Term] id: OBA:1000986 @@ -168759,10 +268108,10 @@ name: vitamin B1 amount def: "The amount of a vitamin B1." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of vitamin B1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26948 ! vitamin B1 -relationship: inheres_in CHEBI:26948 ! vitamin B1 +intersection_of: RO:0000052 CHEBI:26948 ! inheres in vitamin B1 +relationship: RO:0000052 CHEBI:26948 ! inheres in vitamin B1 [Term] id: OBA:1000987 @@ -168771,8 +268120,8 @@ def: "The amount of a glycosphingolipid." [AUTO:patterns/patterns/entity_attribu synonym: "amount of glycosphingolipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000965 ! sphingolipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:24402 ! glycosphingolipid -relationship: inheres_in CHEBI:24402 ! glycosphingolipid +intersection_of: RO:0000052 CHEBI:24402 ! inheres in glycosphingolipid +relationship: RO:0000052 CHEBI:24402 ! inheres in glycosphingolipid [Term] id: OBA:1000988 @@ -168782,8 +268131,8 @@ synonym: "amount of corticotropin" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000079 ! hormone levels is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:3892 ! corticotropin -relationship: inheres_in CHEBI:3892 ! corticotropin +intersection_of: RO:0000052 CHEBI:3892 ! inheres in corticotropin +relationship: RO:0000052 CHEBI:3892 ! inheres in corticotropin [Term] id: OBA:1000989 @@ -168792,8 +268141,8 @@ def: "The amount of a apolipoprotein." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of apolipoprotein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:39015 ! apolipoprotein -relationship: inheres_in CHEBI:39015 ! apolipoprotein +intersection_of: RO:0000052 CHEBI:39015 ! inheres in apolipoprotein +relationship: RO:0000052 CHEBI:39015 ! inheres in apolipoprotein [Term] id: OBA:1000990 @@ -168803,8 +268152,8 @@ synonym: "amount of aldosterone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000079 ! hormone levels is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:27584 ! aldosterone -relationship: inheres_in CHEBI:27584 ! aldosterone +intersection_of: RO:0000052 CHEBI:27584 ! inheres in aldosterone +relationship: RO:0000052 CHEBI:27584 ! inheres in aldosterone [Term] id: OBA:1000991 @@ -168813,8 +268162,8 @@ def: "The amount of a thromboxane." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of thromboxane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26995 ! thromboxane -relationship: inheres_in CHEBI:26995 ! thromboxane +intersection_of: RO:0000052 CHEBI:26995 ! inheres in thromboxane +relationship: RO:0000052 CHEBI:26995 ! inheres in thromboxane [Term] id: OBA:1000992 @@ -168824,8 +268173,8 @@ synonym: "amount of Follicle stimulating hormone" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:81569 ! Follicle stimulating hormone -relationship: inheres_in CHEBI:81569 ! Follicle stimulating hormone +intersection_of: RO:0000052 CHEBI:81569 ! inheres in Follicle stimulating hormone +relationship: RO:0000052 CHEBI:81569 ! inheres in Follicle stimulating hormone [Term] id: OBA:1000993 @@ -168843,8 +268192,8 @@ synonym: "amount of progesterone" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000079 ! hormone levels is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17026 ! progesterone -relationship: inheres_in CHEBI:17026 ! progesterone +intersection_of: RO:0000052 CHEBI:17026 ! inheres in progesterone +relationship: RO:0000052 CHEBI:17026 ! inheres in progesterone [Term] id: OBA:1000995 @@ -168853,19 +268202,19 @@ def: "The amount of a retinol." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of retinol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:50211 ! retinol -relationship: inheres_in CHEBI:50211 ! retinol +intersection_of: RO:0000052 CHEBI:50211 ! inheres in retinol +relationship: RO:0000052 CHEBI:50211 ! inheres in retinol [Term] id: OBA:1000996 name: vitamin A amount def: "The amount of a vitamin A." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of vitamin A" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:12777 ! vitamin A -relationship: inheres_in CHEBI:12777 ! vitamin A +intersection_of: RO:0000052 CHEBI:12777 ! inheres in vitamin A +relationship: RO:0000052 CHEBI:12777 ! inheres in vitamin A [Term] id: OBA:1000997 @@ -168874,8 +268223,8 @@ def: "The amount of a sulfolipid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of sulfolipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:61384 ! sulfolipid -relationship: inheres_in CHEBI:61384 ! sulfolipid +intersection_of: RO:0000052 CHEBI:61384 ! inheres in sulfolipid +relationship: RO:0000052 CHEBI:61384 ! inheres in sulfolipid [Term] id: OBA:1000998 @@ -168884,8 +268233,8 @@ def: "The amount of a bile salt." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of bile salt" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:22868 ! bile salt -relationship: inheres_in CHEBI:22868 ! bile salt +intersection_of: RO:0000052 CHEBI:22868 ! inheres in bile salt +relationship: RO:0000052 CHEBI:22868 ! inheres in bile salt [Term] id: OBA:1000999 @@ -168895,8 +268244,8 @@ synonym: "amount of corticosterone" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000079 ! hormone levels is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16827 ! corticosterone -relationship: inheres_in CHEBI:16827 ! corticosterone +intersection_of: RO:0000052 CHEBI:16827 ! inheres in corticosterone +relationship: RO:0000052 CHEBI:16827 ! inheres in corticosterone [Term] id: OBA:1001000 @@ -168905,8 +268254,8 @@ def: "The amount of a erythropoietin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of erythropoietin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000007141 ! erythropoietin -relationship: inheres_in PR:000007141 ! erythropoietin +intersection_of: RO:0000052 PR:000007141 ! inheres in erythropoietin +relationship: RO:0000052 PR:000007141 ! inheres in erythropoietin [Term] id: OBA:1001001 @@ -168915,8 +268264,8 @@ def: "The amount of a amino acid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of amino acid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:33709 ! amino acid -relationship: inheres_in CHEBI:33709 ! amino acid +intersection_of: RO:0000052 CHEBI:33709 ! inheres in amino acid +relationship: RO:0000052 CHEBI:33709 ! inheres in amino acid [Term] id: OBA:1001002 @@ -168925,8 +268274,8 @@ def: "The amount of a primate-type serum amyloid A-2 protein." [AUTO:patterns/pa synonym: "amount of primate-type serum amyloid A-2 protein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000025853 ! primate-type serum amyloid A-2 protein -relationship: inheres_in PR:000025853 ! primate-type serum amyloid A-2 protein +intersection_of: RO:0000052 PR:000025853 ! inheres in primate-type serum amyloid A-2 protein +relationship: RO:0000052 PR:000025853 ! inheres in primate-type serum amyloid A-2 protein [Term] id: OBA:1001003 @@ -168935,8 +268284,8 @@ def: "The amount of a galactolipid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of galactolipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:5254 ! galactolipid -relationship: inheres_in CHEBI:5254 ! galactolipid +intersection_of: RO:0000052 CHEBI:5254 ! inheres in galactolipid +relationship: RO:0000052 CHEBI:5254 ! inheres in galactolipid [Term] id: OBA:1001004 @@ -168952,8 +268301,8 @@ def: "The amount of a creatine." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of creatine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16919 ! creatine -relationship: inheres_in CHEBI:16919 ! creatine +intersection_of: RO:0000052 CHEBI:16919 ! inheres in creatine +relationship: RO:0000052 CHEBI:16919 ! inheres in creatine [Term] id: OBA:1001006 @@ -168962,8 +268311,8 @@ def: "The amount of a glutamate decarboxylase 1." [AUTO:patterns/patterns/entity synonym: "amount of glutamate decarboxylase 1" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000007785 ! glutamate decarboxylase 1 -relationship: inheres_in PR:000007785 ! glutamate decarboxylase 1 +intersection_of: RO:0000052 PR:000007785 ! inheres in glutamate decarboxylase 1 +relationship: RO:0000052 PR:000007785 ! inheres in glutamate decarboxylase 1 [Term] id: OBA:1001007 @@ -168972,8 +268321,8 @@ def: "The amount of a glutathione." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of glutathione" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16856 ! glutathione -relationship: inheres_in CHEBI:16856 ! glutathione +intersection_of: RO:0000052 CHEBI:16856 ! inheres in glutathione +relationship: RO:0000052 CHEBI:16856 ! inheres in glutathione [Term] id: OBA:1001008 @@ -168982,8 +268331,8 @@ def: "The amount of a phytosterols." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of phytosterols" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000973 ! sterol amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:26125 ! phytosterols -relationship: inheres_in CHEBI:26125 ! phytosterols +intersection_of: RO:0000052 CHEBI:26125 ! inheres in phytosterols +relationship: RO:0000052 CHEBI:26125 ! inheres in phytosterols [Term] id: OBA:1001009 @@ -168993,8 +268342,8 @@ synonym: "amount of Luteinizing hormone" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:81568 ! Luteinizing hormone -relationship: inheres_in CHEBI:81568 ! Luteinizing hormone +intersection_of: RO:0000052 CHEBI:81568 ! inheres in Luteinizing hormone +relationship: RO:0000052 CHEBI:81568 ! inheres in Luteinizing hormone [Term] id: OBA:1001010 @@ -169003,8 +268352,8 @@ def: "The amount of a thyroxine." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of thyroxine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001001 ! amino acid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:30660 ! thyroxine -relationship: inheres_in CHEBI:30660 ! thyroxine +intersection_of: RO:0000052 CHEBI:30660 ! inheres in thyroxine +relationship: RO:0000052 CHEBI:30660 ! inheres in thyroxine [Term] id: OBA:1001011 @@ -169013,8 +268362,8 @@ def: "The amount of a phospholipid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of phospholipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16247 ! phospholipid -relationship: inheres_in CHEBI:16247 ! phospholipid +intersection_of: RO:0000052 CHEBI:16247 ! inheres in phospholipid +relationship: RO:0000052 CHEBI:16247 ! inheres in phospholipid [Term] id: OBA:1001012 @@ -169023,18 +268372,18 @@ def: "The amount of a neopterin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of neopterin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000944 ! neopterins amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:28670 ! neopterin -relationship: inheres_in CHEBI:28670 ! neopterin +intersection_of: RO:0000052 CHEBI:28670 ! inheres in neopterin +relationship: RO:0000052 CHEBI:28670 ! inheres in neopterin [Term] id: OBA:1001013 -name: tumor necrosis factor amount +name: tumor necrosis factor alpha amount def: "The amount of a tumor necrosis factor." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of tumor necrosis factor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000000134 ! tumor necrosis factor -relationship: inheres_in PR:000000134 ! tumor necrosis factor +intersection_of: RO:0000052 PR:000000134 ! inheres in tumor necrosis factor +relationship: RO:0000052 PR:000000134 ! inheres in tumor necrosis factor [Term] id: OBA:1001014 @@ -169044,8 +268393,8 @@ synonym: "amount of sphingomyelin" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000965 ! sphingolipid amount is_a: OBA:1001011 ! phospholipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:64583 ! sphingomyelin -relationship: inheres_in CHEBI:64583 ! sphingomyelin +intersection_of: RO:0000052 CHEBI:64583 ! inheres in sphingomyelin +relationship: RO:0000052 CHEBI:64583 ! inheres in sphingomyelin [Term] id: OBA:1001015 @@ -169053,10 +268402,10 @@ name: folic acid amount def: "The amount of a folic acid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of folic acid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount -is_a: OBA:1000982 ! vitamin (role) amount +is_a: OBA:1000982 ! vitamin amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:27470 ! folic acid -relationship: inheres_in CHEBI:27470 ! folic acid +intersection_of: RO:0000052 CHEBI:27470 ! inheres in folic acid +relationship: RO:0000052 CHEBI:27470 ! inheres in folic acid [Term] id: OBA:1001016 @@ -169070,8 +268419,8 @@ def: "The amount of a lipoprotein." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of lipoprotein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:6495 ! lipoprotein -relationship: inheres_in CHEBI:6495 ! lipoprotein +intersection_of: RO:0000052 CHEBI:6495 ! inheres in lipoprotein +relationship: RO:0000052 CHEBI:6495 ! inheres in lipoprotein [Term] id: OBA:1001018 @@ -169216,8 +268565,8 @@ synonym: "morphology of mesentery" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002095 ! mesentery -relationship: inheres_in UBERON:0002095 ! mesentery +intersection_of: RO:0000052 UBERON:0002095 ! inheres in mesentery +relationship: RO:0000052 UBERON:0002095 ! inheres in mesentery [Term] id: OBA:1001046 @@ -169227,8 +268576,8 @@ synonym: "morphology of ocular adnexa" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0035639 ! ocular adnexa -relationship: inheres_in UBERON:0035639 ! ocular adnexa +intersection_of: RO:0000052 UBERON:0035639 ! inheres in ocular adnexa +relationship: RO:0000052 UBERON:0035639 ! inheres in ocular adnexa [Term] id: OBA:1001047 @@ -169238,8 +268587,8 @@ synonym: "morphology of common tendinous ring" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014796 ! common tendinous ring -relationship: inheres_in UBERON:0014796 ! common tendinous ring +intersection_of: RO:0000052 UBERON:0014796 ! inheres in common tendinous ring +relationship: RO:0000052 UBERON:0014796 ! inheres in common tendinous ring [Term] id: OBA:1001048 @@ -169248,8 +268597,8 @@ def: "The morphology of a common iliac artery." [AUTO:patterns/patterns/entity_a synonym: "morphology of common iliac artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010643 ! iliac artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001191 ! common iliac artery -relationship: inheres_in UBERON:0001191 ! common iliac artery +intersection_of: RO:0000052 UBERON:0001191 ! inheres in common iliac artery +relationship: RO:0000052 UBERON:0001191 ! inheres in common iliac artery [Term] id: OBA:1001049 @@ -169258,8 +268607,8 @@ def: "The morphology of a external capsule of telencephalon." [AUTO:patterns/pat synonym: "morphology of external capsule of telencephalon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004276 ! brain white matter morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004545 ! external capsule of telencephalon -relationship: inheres_in UBERON:0004545 ! external capsule of telencephalon +intersection_of: RO:0000052 UBERON:0004545 ! inheres in external capsule of telencephalon +relationship: RO:0000052 UBERON:0004545 ! inheres in external capsule of telencephalon [Term] id: OBA:1001050 @@ -169268,8 +268617,8 @@ def: "The morphology of a ectoderm." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of ectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001060 ! germ layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000924 ! ectoderm -relationship: inheres_in UBERON:0000924 ! ectoderm +intersection_of: RO:0000052 UBERON:0000924 ! inheres in ectoderm +relationship: RO:0000052 UBERON:0000924 ! inheres in ectoderm [Term] id: OBA:1001051 @@ -169278,8 +268627,8 @@ def: "The morphology of a mural trophectoderm." [AUTO:patterns/patterns/entity_a synonym: "morphology of mural trophectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006265 ! mural trophectoderm -relationship: inheres_in UBERON:0006265 ! mural trophectoderm +intersection_of: RO:0000052 UBERON:0006265 ! inheres in mural trophectoderm +relationship: RO:0000052 UBERON:0006265 ! inheres in mural trophectoderm [Term] id: OBA:1001052 @@ -169289,8 +268638,8 @@ synonym: "morphology of sternocostal joint" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000205 ! synovial joint quality is_a: OBA:1001080 ! joint of rib morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001998 ! sternocostal joint -relationship: inheres_in UBERON:0001998 ! sternocostal joint +intersection_of: RO:0000052 UBERON:0001998 ! inheres in sternocostal joint +relationship: RO:0000052 UBERON:0001998 ! inheres in sternocostal joint [Term] id: OBA:1001053 @@ -169300,8 +268649,8 @@ synonym: "morphology of pleuropericardial folds" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006278 ! pleuropericardial folds -relationship: inheres_in UBERON:0006278 ! pleuropericardial folds +intersection_of: RO:0000052 UBERON:0006278 ! inheres in pleuropericardial folds +relationship: RO:0000052 UBERON:0006278 ! inheres in pleuropericardial folds [Term] id: OBA:1001054 @@ -169310,8 +268659,8 @@ def: "The morphology of a neural tube." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of neural tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001049 ! neural tube -relationship: inheres_in UBERON:0001049 ! neural tube +intersection_of: RO:0000052 UBERON:0001049 ! inheres in neural tube +relationship: RO:0000052 UBERON:0001049 ! inheres in neural tube [Term] id: OBA:1001055 @@ -169321,8 +268670,8 @@ synonym: "morphology of ciliary epithelium" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001778 ! ciliary epithelium -relationship: inheres_in UBERON:0001778 ! ciliary epithelium +intersection_of: RO:0000052 UBERON:0001778 ! inheres in ciliary epithelium +relationship: RO:0000052 UBERON:0001778 ! inheres in ciliary epithelium [Term] id: OBA:1001056 @@ -169332,8 +268681,8 @@ synonym: "morphology of embryonic cloacal fold" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012292 ! embryonic cloacal fold -relationship: inheres_in UBERON:0012292 ! embryonic cloacal fold +intersection_of: RO:0000052 UBERON:0012292 ! inheres in embryonic cloacal fold +relationship: RO:0000052 UBERON:0012292 ! inheres in embryonic cloacal fold [Term] id: OBA:1001057 @@ -169343,8 +268692,8 @@ synonym: "morphology of parotid gland myoepithelium" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0035076 ! parotid gland myoepithelium -relationship: inheres_in UBERON:0035076 ! parotid gland myoepithelium +intersection_of: RO:0000052 UBERON:0035076 ! inheres in parotid gland myoepithelium +relationship: RO:0000052 UBERON:0035076 ! inheres in parotid gland myoepithelium [Term] id: OBA:1001058 @@ -169353,8 +268702,8 @@ def: "The morphology of a excitatory synapse." [AUTO:patterns/patterns/entity_at synonym: "morphology of excitatory synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0060076 ! excitatory synapse -relationship: inheres_in GO:0060076 ! excitatory synapse +intersection_of: RO:0000052 GO:0060076 ! inheres in excitatory synapse +relationship: RO:0000052 GO:0060076 ! inheres in excitatory synapse [Term] id: OBA:1001059 @@ -169363,8 +268712,8 @@ def: "The morphology of a polar trophectoderm." [AUTO:patterns/patterns/entity_a synonym: "morphology of polar trophectoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006280 ! polar trophectoderm -relationship: inheres_in UBERON:0006280 ! polar trophectoderm +intersection_of: RO:0000052 UBERON:0006280 ! inheres in polar trophectoderm +relationship: RO:0000052 UBERON:0006280 ! inheres in polar trophectoderm [Term] id: OBA:1001060 @@ -169373,8 +268722,8 @@ def: "The morphology of a germ layer." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of germ layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000923 ! germ layer -relationship: inheres_in UBERON:0000923 ! germ layer +intersection_of: RO:0000052 UBERON:0000923 ! inheres in germ layer +relationship: RO:0000052 UBERON:0000923 ! inheres in germ layer [Term] id: OBA:1001061 @@ -169383,8 +268732,8 @@ def: "The morphology of a mesoderm." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001060 ! germ layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000926 ! mesoderm -relationship: inheres_in UBERON:0000926 ! mesoderm +intersection_of: RO:0000052 UBERON:0000926 ! inheres in mesoderm +relationship: RO:0000052 UBERON:0000926 ! inheres in mesoderm [Term] id: OBA:1001062 @@ -169394,8 +268743,8 @@ synonym: "morphology of hemotrichorial placental membrane" EXACT [AUTO:patterns/ is_a: OBA:1000481 ! placental membrane quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014849 ! hemotrichorial placental membrane -relationship: inheres_in UBERON:0014849 ! hemotrichorial placental membrane +intersection_of: RO:0000052 UBERON:0014849 ! inheres in hemotrichorial placental membrane +relationship: RO:0000052 UBERON:0014849 ! inheres in hemotrichorial placental membrane [Term] id: OBA:1001063 @@ -169405,8 +268754,8 @@ synonym: "morphology of platelet alpha granule" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000078 ! attribute of organelle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0031091 ! platelet alpha granule -relationship: inheres_in GO:0031091 ! platelet alpha granule +intersection_of: RO:0000052 GO:0031091 ! inheres in platelet alpha granule +relationship: RO:0000052 GO:0031091 ! inheres in platelet alpha granule [Term] id: OBA:1001064 @@ -169415,8 +268764,8 @@ def: "The morphology of a extraembryonic mesoderm." [AUTO:patterns/patterns/enti synonym: "morphology of extraembryonic mesoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005728 ! extraembryonic mesoderm -relationship: inheres_in UBERON:0005728 ! extraembryonic mesoderm +intersection_of: RO:0000052 UBERON:0005728 ! inheres in extraembryonic mesoderm +relationship: RO:0000052 UBERON:0005728 ! inheres in extraembryonic mesoderm [Term] id: OBA:1001065 @@ -169426,7 +268775,7 @@ synonym: "morphology of cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000000 ! cell +intersection_of: RO:0000052 CL:0000000 ! inheres in cell [Term] id: OBA:1001066 @@ -169435,8 +268784,8 @@ def: "The morphology of a melanophage." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of melanophage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002060 ! melanophage -relationship: inheres_in CL:0002060 ! melanophage +intersection_of: RO:0000052 CL:0002060 ! inheres in melanophage +relationship: RO:0000052 CL:0002060 ! inheres in melanophage [Term] id: OBA:1001067 @@ -169445,8 +268794,8 @@ def: "The morphology of a costotransverse joint." [AUTO:patterns/patterns/entity synonym: "morphology of costotransverse joint" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001082 ! costovertebral joint morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011967 ! costotransverse joint -relationship: inheres_in UBERON:0011967 ! costotransverse joint +intersection_of: RO:0000052 UBERON:0011967 ! inheres in costotransverse joint +relationship: RO:0000052 UBERON:0011967 ! inheres in costotransverse joint [Term] id: OBA:1001069 @@ -169455,8 +268804,8 @@ def: "The morphology of a symmetric synapse." [AUTO:patterns/patterns/entity_att synonym: "morphology of symmetric synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0032280 ! symmetric synapse -relationship: inheres_in GO:0032280 ! symmetric synapse +intersection_of: RO:0000052 GO:0032280 ! inheres in symmetric synapse +relationship: RO:0000052 GO:0032280 ! inheres in symmetric synapse [Term] id: OBA:1001070 @@ -169466,8 +268815,8 @@ synonym: "morphology of rhombomere boundary" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0018239 ! rhombomere boundary -relationship: inheres_in UBERON:0018239 ! rhombomere boundary +intersection_of: RO:0000052 UBERON:0018239 ! inheres in rhombomere boundary +relationship: RO:0000052 UBERON:0018239 ! inheres in rhombomere boundary [Term] id: OBA:1001071 @@ -169476,8 +268825,8 @@ def: "The morphology of a asymmetric synapse." [AUTO:patterns/patterns/entity_at synonym: "morphology of asymmetric synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0032279 ! asymmetric synapse -relationship: inheres_in GO:0032279 ! asymmetric synapse +intersection_of: RO:0000052 GO:0032279 ! inheres in asymmetric synapse +relationship: RO:0000052 GO:0032279 ! inheres in asymmetric synapse [Term] id: OBA:1001072 @@ -169486,8 +268835,8 @@ def: "The morphology of a ribbon synapse." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of ribbon synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097470 ! ribbon synapse -relationship: inheres_in GO:0097470 ! ribbon synapse +intersection_of: RO:0000052 GO:0097470 ! inheres in ribbon synapse +relationship: RO:0000052 GO:0097470 ! inheres in ribbon synapse [Term] id: OBA:1001073 @@ -169497,8 +268846,8 @@ synonym: "morphology of urachus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002068 ! urachus -relationship: inheres_in UBERON:0002068 ! urachus +intersection_of: RO:0000052 UBERON:0002068 ! inheres in urachus +relationship: RO:0000052 UBERON:0002068 ! inheres in urachus [Term] id: OBA:1001074 @@ -169507,8 +268856,8 @@ def: "The morphology of a endoderm." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of endoderm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001060 ! germ layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000925 ! endoderm -relationship: inheres_in UBERON:0000925 ! endoderm +intersection_of: RO:0000052 UBERON:0000925 ! inheres in endoderm +relationship: RO:0000052 UBERON:0000925 ! inheres in endoderm [Term] id: OBA:1001075 @@ -169517,8 +268866,8 @@ def: "The morphology of a uncondensed odontogenic mesenchyme." [AUTO:patterns/pa synonym: "morphology of uncondensed odontogenic mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005369 ! head mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003856 ! uncondensed odontogenic mesenchyme -relationship: inheres_in UBERON:0003856 ! uncondensed odontogenic mesenchyme +intersection_of: RO:0000052 UBERON:0003856 ! inheres in uncondensed odontogenic mesenchyme +relationship: RO:0000052 UBERON:0003856 ! inheres in uncondensed odontogenic mesenchyme [Term] id: OBA:1001076 @@ -169528,7 +268877,7 @@ synonym: "morphology of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000069 ! embryo trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:1001077 @@ -169537,8 +268886,8 @@ def: "The morphology of a lamina terminalis of neural tube." [AUTO:patterns/patt synonym: "morphology of lamina terminalis of neural tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005078 ! lamina terminalis of neural tube -relationship: inheres_in UBERON:0005078 ! lamina terminalis of neural tube +intersection_of: RO:0000052 UBERON:0005078 ! inheres in lamina terminalis of neural tube +relationship: RO:0000052 UBERON:0005078 ! inheres in lamina terminalis of neural tube [Term] id: OBA:1001078 @@ -169547,8 +268896,8 @@ def: "The morphology of a beige adipocyte." [AUTO:patterns/patterns/entity_attri synonym: "morphology of beige adipocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004128 ! adipocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0001070 ! beige adipocyte -relationship: inheres_in CL:0001070 ! beige adipocyte +intersection_of: RO:0000052 CL:0001070 ! inheres in beige adipocyte +relationship: RO:0000052 CL:0001070 ! inheres in beige adipocyte [Term] id: OBA:1001079 @@ -169557,8 +268906,8 @@ def: "The morphology of a inhibitory synapse." [AUTO:patterns/patterns/entity_at synonym: "morphology of inhibitory synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0060077 ! inhibitory synapse -relationship: inheres_in GO:0060077 ! inhibitory synapse +intersection_of: RO:0000052 GO:0060077 ! inheres in inhibitory synapse +relationship: RO:0000052 GO:0060077 ! inheres in inhibitory synapse [Term] id: OBA:1001080 @@ -169567,8 +268916,8 @@ def: "The morphology of a joint of rib." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of joint of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003754 ! skeletal joint morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002001 ! joint of rib -relationship: inheres_in UBERON:0002001 ! joint of rib +intersection_of: RO:0000052 UBERON:0002001 ! inheres in joint of rib +relationship: RO:0000052 UBERON:0002001 ! inheres in joint of rib [Term] id: OBA:1001081 @@ -169578,8 +268927,8 @@ synonym: "morphology of blastocyst" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000358 ! blastocyst -relationship: inheres_in UBERON:0000358 ! blastocyst +intersection_of: RO:0000052 UBERON:0000358 ! inheres in blastocyst +relationship: RO:0000052 UBERON:0000358 ! inheres in blastocyst [Term] id: OBA:1001082 @@ -169589,8 +268938,8 @@ synonym: "morphology of costovertebral joint" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000205 ! synovial joint quality is_a: OBA:1001080 ! joint of rib morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002292 ! costovertebral joint -relationship: inheres_in UBERON:0002292 ! costovertebral joint +intersection_of: RO:0000052 UBERON:0002292 ! inheres in costovertebral joint +relationship: RO:0000052 UBERON:0002292 ! inheres in costovertebral joint [Term] id: OBA:1001083 @@ -169600,7 +268949,7 @@ synonym: "morphology of circle of Willis" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0005507 ! systemic artery morphology is_a: OBA:1000495 ! circle of Willis quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003709 ! circle of Willis +intersection_of: RO:0000052 UBERON:0003709 ! inheres in circle of Willis [Term] id: OBA:1001084 @@ -169610,8 +268959,8 @@ synonym: "osmolality of feces" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0002027 ! osmolality intersection_of: PATO:0002027 ! osmolality -intersection_of: inheres_in UBERON:0001988 ! feces -relationship: inheres_in UBERON:0001988 ! feces +intersection_of: RO:0000052 UBERON:0001988 ! inheres in feces +relationship: RO:0000052 UBERON:0001988 ! inheres in feces [Term] id: OBA:1001085 @@ -169622,8 +268971,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0002417 ! abdominal segment of trunk -relationship: inheres_in UBERON:0002417 ! abdominal segment of trunk +intersection_of: RO:0000052 UBERON:0002417 ! inheres in abdominal segment of trunk +relationship: RO:0000052 UBERON:0002417 ! inheres in abdominal segment of trunk [Term] id: OBA:1001086 @@ -169632,8 +268981,8 @@ def: "The duration of a http://purl.obolibrary.org/obo/EFO_0005054." [AUTO:patte synonym: "duration of http://purl.obolibrary.org/obo/EFO_0005054" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in EFO:0005054 -relationship: inheres_in EFO:0005054 +intersection_of: RO:0000052 EFO:0005054 ! inheres in +relationship: RO:0000052 EFO:0005054 ! inheres in [Term] id: OBA:1001087 @@ -169643,8 +268992,8 @@ synonym: "rate of heart contraction" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate -intersection_of: inheres_in GO:0060047 ! heart contraction -relationship: inheres_in GO:0060047 ! heart contraction +intersection_of: RO:0000052 GO:0060047 ! inheres in heart contraction +relationship: RO:0000052 GO:0060047 ! inheres in heart contraction [Term] id: OBA:1001088 @@ -169659,7 +269008,7 @@ synonym: "biological sex of multicellular organism" EXACT [AUTO:patterns/pattern is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000047 ! biological sex intersection_of: PATO:0000047 ! biological sex -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:1001090 @@ -169669,7 +269018,7 @@ synonym: "color of feather" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT1000664 ! feather morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0000022 ! feather +intersection_of: RO:0000052 UBERON:0000022 ! inheres in feather [Term] id: OBA:1001091 @@ -169678,8 +269027,8 @@ def: "The quality of a eggshell." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of eggshell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005079 ! eggshell -relationship: inheres_in UBERON:0005079 ! eggshell +intersection_of: RO:0000052 UBERON:0005079 ! inheres in eggshell +relationship: RO:0000052 UBERON:0005079 ! inheres in eggshell [Term] id: OBA:1001092 @@ -169689,7 +269038,1809 @@ synonym: "color of eggshell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001091 ! egg shell trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0005079 ! eggshell +intersection_of: RO:0000052 UBERON:0005079 ! inheres in eggshell + +[Term] +id: OBA:2001000 +name: age of onset of Alzheimer disease +def: "The age at which Alzheimer disease manifestations first appear." [] +synonym: "age Alzheimer disease symptoms begin" EXACT [] +synonym: "age at onset of Alzheimer disease" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004975 ! inheres in Alzheimer disease +relationship: RO:0000052 MONDO:0004975 ! inheres in Alzheimer disease + +[Term] +id: OBA:2001001 +name: age of onset of asthma +def: "The age at which asthma manifestations first appear." [] +synonym: "age asthma symptoms begin" EXACT [] +synonym: "age at onset of asthma" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004979 ! inheres in asthma +relationship: RO:0000052 MONDO:0004979 ! inheres in asthma + +[Term] +id: OBA:2001002 +name: age of onset of urinary bladder carcinoma +def: "The age at which urinary bladder carcinoma manifestations first appear." [] +synonym: "age at onset of urinary bladder carcinoma" EXACT [] +synonym: "age urinary bladder carcinoma symptoms begin" EXACT [] +is_a: OBA:2040153 ! age of onset of cancer +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004986 ! inheres in urinary bladder carcinoma +relationship: RO:0000052 MONDO:0004986 ! inheres in urinary bladder carcinoma + +[Term] +id: OBA:2001004 +name: age of onset of cataract +def: "The age at which cataract manifestations first appear." [] +synonym: "age at onset of cataract" EXACT [] +synonym: "age cataract symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005129 ! inheres in cataract +relationship: RO:0000052 MONDO:0005129 ! inheres in cataract + +[Term] +id: OBA:2001007 +name: age of onset of hyperlipidemia +def: "The age at which hyperlipidemia manifestations first appear." [] +synonym: "age at onset of hyperlipidemia" EXACT [] +synonym: "age hyperlipidemia symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0021187 ! inheres in hyperlipidemia +relationship: RO:0000052 MONDO:0021187 ! inheres in hyperlipidemia + +[Term] +id: OBA:2001008 +name: age of onset of osteoarthritis +def: "The age at which osteoarthritis manifestations first appear." [] +synonym: "age at onset of osteoarthritis" EXACT [] +synonym: "age osteoarthritis symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005178 ! inheres in osteoarthritis +relationship: RO:0000052 MONDO:0005178 ! inheres in osteoarthritis + +[Term] +id: OBA:2001009 +name: age of onset of Parkinson disease +def: "The age at which Parkinson disease manifestations first appear." [] +synonym: "age at onset of Parkinson disease" EXACT [] +synonym: "age Parkinson disease symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005180 ! inheres in Parkinson disease +relationship: RO:0000052 MONDO:0005180 ! inheres in Parkinson disease + +[Term] +id: OBA:2001010 +name: age of onset of essential hypertension +def: "The age at which essential hypertension manifestations first appear." [] +synonym: "age at onset of essential hypertension" EXACT [] +synonym: "age essential hypertension symptoms begin" EXACT [] +is_a: OBA:2040159 ! age of onset of hypertensive disorder +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0001134 ! inheres in essential hypertension +relationship: RO:0000052 MONDO:0001134 ! inheres in essential hypertension + +[Term] +id: OBA:2001011 +name: age of onset of schizophrenia +def: "The age at which schizophrenia manifestations first appear." [] +synonym: "age at onset of schizophrenia" EXACT [] +synonym: "age schizophrenia symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005090 ! inheres in schizophrenia +relationship: RO:0000052 MONDO:0005090 ! inheres in schizophrenia + +[Term] +id: OBA:2001012 +name: age of onset of type 1 diabetes mellitus +def: "The age at which type 1 diabetes mellitus manifestations first appear." [] +synonym: "age at onset of type 1 diabetes mellitus" EXACT [] +synonym: "age type 1 diabetes mellitus symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005147 ! inheres in type 1 diabetes mellitus +relationship: RO:0000052 MONDO:0005147 ! inheres in type 1 diabetes mellitus + +[Term] +id: OBA:2001013 +name: age of onset of type 2 diabetes mellitus +def: "The age at which type 2 diabetes mellitus manifestations first appear." [] +synonym: "age at onset of type 2 diabetes mellitus" EXACT [] +synonym: "age type 2 diabetes mellitus symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005148 ! inheres in type 2 diabetes mellitus +relationship: RO:0000052 MONDO:0005148 ! inheres in type 2 diabetes mellitus + +[Term] +id: OBA:2001015 +name: age of onset of childhood onset asthma +def: "The age at which childhood onset asthma manifestations first appear." [] +synonym: "age at onset of childhood onset asthma" EXACT [] +synonym: "age childhood onset asthma symptoms begin" EXACT [] +is_a: OBA:2001001 ! age of onset of asthma +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005405 ! inheres in childhood onset asthma +relationship: RO:0000052 MONDO:0005405 ! inheres in childhood onset asthma + +[Term] +id: OBA:2001016 +name: age of onset of alcohol dependence +def: "The age at which alcohol dependence manifestations first appear." [] +synonym: "age alcohol dependence symptoms begin" EXACT [] +synonym: "age at onset of alcohol dependence" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0007079 ! inheres in alcohol dependence +relationship: RO:0000052 MONDO:0007079 ! inheres in alcohol dependence + +[Term] +id: OBA:2001017 +name: age of onset of allergic disease +def: "The age at which allergic disease manifestations first appear." [] +synonym: "age allergic disease symptoms begin" EXACT [] +synonym: "age at onset of allergic disease" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005271 ! inheres in allergic disease +relationship: RO:0000052 MONDO:0005271 ! inheres in allergic disease + +[Term] +id: OBA:2001018 +name: age of onset of amyotrophic lateral sclerosis +def: "The age at which amyotrophic lateral sclerosis manifestations first appear." [] +synonym: "age amyotrophic lateral sclerosis symptoms begin" EXACT [] +synonym: "age at onset of amyotrophic lateral sclerosis" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004976 ! inheres in amyotrophic lateral sclerosis +relationship: RO:0000052 MONDO:0004976 ! inheres in amyotrophic lateral sclerosis + +[Term] +id: OBA:2001019 +name: age of onset of bipolar disorder +def: "The age at which bipolar disorder manifestations first appear." [] +synonym: "age at onset of bipolar disorder" EXACT [] +synonym: "age bipolar disorder symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004985 ! inheres in bipolar disorder +relationship: RO:0000052 MONDO:0004985 ! inheres in bipolar disorder + +[Term] +id: OBA:2001020 +name: age of onset of Buruli ulcer disease +def: "The age at which Buruli ulcer disease manifestations first appear." [] +synonym: "age at onset of Buruli ulcer disease" EXACT [] +synonym: "age Buruli ulcer disease symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0000327 ! inheres in Buruli ulcer disease +relationship: RO:0000052 MONDO:0000327 ! inheres in Buruli ulcer disease + +[Term] +id: OBA:2001022 +name: age of onset of frontotemporal dementia +def: "The age at which frontotemporal dementia manifestations first appear." [] +synonym: "age at onset of frontotemporal dementia" EXACT [] +synonym: "age frontotemporal dementia symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0017276 ! inheres in frontotemporal dementia +relationship: RO:0000052 MONDO:0017276 ! inheres in frontotemporal dementia + +[Term] +id: OBA:2001024 +name: age of onset of Huntington disease +def: "The age at which Huntington disease manifestations first appear." [] +synonym: "age at onset of Huntington disease" EXACT [] +synonym: "age Huntington disease symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0007739 ! inheres in Huntington disease +relationship: RO:0000052 MONDO:0007739 ! inheres in Huntington disease + +[Term] +id: OBA:2001026 +name: age of onset of migraine disorder +def: "The age at which migraine disorder manifestations first appear." [] +synonym: "age at onset of migraine disorder" EXACT [] +synonym: "age migraine disorder symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005277 ! inheres in migraine disorder +relationship: RO:0000052 MONDO:0005277 ! inheres in migraine disorder + +[Term] +id: OBA:2001027 +name: age of onset of migraine with aura +def: "The age at which migraine with aura manifestations first appear." [] +synonym: "age at onset of migraine with aura" EXACT [] +synonym: "age migraine with aura symptoms begin" EXACT [] +is_a: OBA:2001026 ! age of onset of migraine disorder +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005475 ! inheres in migraine with aura +relationship: RO:0000052 MONDO:0005475 ! inheres in migraine with aura + +[Term] +id: OBA:2001028 +name: age of onset of migraine without aura +def: "The age at which migraine without aura manifestations first appear." [] +synonym: "age at onset of migraine without aura" EXACT [] +synonym: "age migraine without aura symptoms begin" EXACT [] +is_a: OBA:2001026 ! age of onset of migraine disorder +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0100431 ! inheres in migraine without aura +relationship: RO:0000052 MONDO:0100431 ! inheres in migraine without aura + +[Term] +id: OBA:2001029 +name: age of onset of multiple sclerosis +def: "The age at which multiple sclerosis manifestations first appear." [] +synonym: "age at onset of multiple sclerosis" EXACT [] +synonym: "age multiple sclerosis symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005301 ! inheres in multiple sclerosis +relationship: RO:0000052 MONDO:0005301 ! inheres in multiple sclerosis + +[Term] +id: OBA:2001030 +name: age of onset of myopia +def: "The age at which myopia manifestations first appear." [] +synonym: "age at onset of myopia" EXACT [] +synonym: "age myopia symptoms begin" EXACT [] +is_a: OBA:2001031 ! age of onset of refractive error +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0001384 ! inheres in myopia +relationship: RO:0000052 MONDO:0001384 ! inheres in myopia + +[Term] +id: OBA:2001031 +name: age of onset of refractive error +def: "The age at which refractive error manifestations first appear." [] +synonym: "age at onset of refractive error" EXACT [] +synonym: "age refractive error symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004892 ! inheres in refractive error +relationship: RO:0000052 MONDO:0004892 ! inheres in refractive error + +[Term] +id: OBA:2001032 +name: age of onset of narcolepsy-cataplexy syndrome +def: "The age at which narcolepsy-cataplexy syndrome manifestations first appear." [] +synonym: "age at onset of narcolepsy-cataplexy syndrome" EXACT [] +synonym: "age narcolepsy-cataplexy syndrome symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0016158 ! inheres in narcolepsy-cataplexy syndrome +relationship: RO:0000052 MONDO:0016158 ! inheres in narcolepsy-cataplexy syndrome + +[Term] +id: OBA:2001033 +name: age of onset of coronary atherosclerosis +def: "The age at which coronary atherosclerosis manifestations first appear." [] +synonym: "age at onset of coronary atherosclerosis" EXACT [] +synonym: "age coronary atherosclerosis symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0021661 ! inheres in coronary atherosclerosis +relationship: RO:0000052 MONDO:0021661 ! inheres in coronary atherosclerosis + +[Term] +id: OBA:2040000 +name: trait in response to warfarin +def: "A trait that affects the response to a stimulus with warfarin." [] +synonym: "response to warfarin trait" EXACT [] +is_a: OBA:2040082 ! trait in response to anticoagulant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040001 +name: trait in response to zileuton +def: "A trait that affects the response to a stimulus with zileuton." [] +synonym: "response to zileuton trait" EXACT [] +is_a: OBA:2040044 ! trait in response to non-steroidal anti-inflammatory drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040002 +name: trait in response to ziprasidone +def: "A trait that affects the response to a stimulus with ziprasidone." [] +synonym: "response to ziprasidone trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040003 +name: trait in response to zonisamide +def: "A trait that affects the response to a stimulus with zonisamide." [] +synonym: "response to zonisamide trait" EXACT [] +is_a: OBA:2040050 ! trait in response to anticonvulsant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040004 +name: trait in response to erlotinib +def: "A trait that affects the response to a stimulus with erlotinib." [] +synonym: "response to erlotinib trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040005 +name: trait in response to efavirenz +def: "A trait that affects the response to a stimulus with efavirenz." [] +synonym: "response to efavirenz trait" EXACT [] +is_a: OBA:2040053 ! trait in response to antiviral drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040006 +name: trait in response to radiosensitizing agent +def: "A trait that affects the response to a stimulus with radiosensitizing agent." [] +synonym: "response to radiosensitizing agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040007 +name: trait in response to tafenoquine +def: "A trait that affects the response to a stimulus with tafenoquine." [] +synonym: "response to tafenoquine trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040008 +name: trait in response to migalastat +def: "A trait that affects the response to a stimulus with migalastat." [] +synonym: "response to migalastat trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040009 +name: trait in response to endocrine disruptor +def: "A trait that affects the response to a stimulus with endocrine disruptor." [] +synonym: "response to endocrine disruptor trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040010 +name: trait in response to acetylsalicylic acid +def: "A trait that affects the response to a stimulus with acetylsalicylic acid." [] +synonym: "response to acetylsalicylic acid trait" EXACT [] +is_a: OBA:2040044 ! trait in response to non-steroidal anti-inflammatory drug +is_a: OBA:2040082 ! trait in response to anticoagulant +is_a: OBA:2040084 ! trait in response to platelet aggregation inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040011 +name: trait in response to mycophenolic acid +def: "A trait that affects the response to a stimulus with mycophenolic acid." [] +synonym: "response to mycophenolic acid trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040012 +name: trait in response to morphine +def: "A trait that affects the response to a stimulus with morphine." [] +synonym: "response to morphine trait" EXACT [] +is_a: OBA:2040018 ! trait in response to isoquinoline alkaloid +is_a: OBA:2040095 ! trait in response to opioid agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040013 +name: trait in response to gemcitabine +def: "A trait that affects the response to a stimulus with gemcitabine." [] +synonym: "response to gemcitabine trait" EXACT [] +is_a: OBA:2040006 ! trait in response to radiosensitizing agent +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +is_a: OBA:2040053 ! trait in response to antiviral drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040014 +name: trait in response to vitamin B3 +def: "A trait that affects the response to a stimulus with vitamin B3." [] +synonym: "response to vitamin B3 trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040035 ! trait in response to vitamin +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040015 +name: trait in response to bleomycin +def: "A trait that affects the response to a stimulus with bleomycin." [] +synonym: "response to bleomycin trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040016 +name: trait in response to drug +def: "A trait that affects the response to a stimulus with drug." [] +synonym: "response to drug trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040017 +name: trait in response to glucocorticoid +def: "A trait that affects the response to a stimulus with glucocorticoid." [] +synonym: "response to glucocorticoid trait" EXACT [] +is_a: OBA:2040088 ! trait in response to corticosteroid +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040018 +name: trait in response to isoquinoline alkaloid +def: "A trait that affects the response to a stimulus with isoquinoline alkaloid." [] +synonym: "response to isoquinoline alkaloid trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040019 +name: trait in response to camptothecin +def: "A trait that affects the response to a stimulus with camptothecin." [] +synonym: "response to camptothecin trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040113 ! trait in response to topoisomerase inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040020 +name: trait in response to cisplatin +def: "A trait that affects the response to a stimulus with cisplatin." [] +synonym: "response to cisplatin trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040021 +name: trait in response to vancomycin +def: "A trait that affects the response to a stimulus with vancomycin." [] +synonym: "response to vancomycin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040022 +name: trait in response to rifampicin +def: "A trait that affects the response to a stimulus with rifampicin." [] +synonym: "response to rifampicin trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040023 +name: trait in response to heparin +def: "A trait that affects the response to a stimulus with heparin." [] +synonym: "response to heparin trait" EXACT [] +is_a: OBA:2040082 ! trait in response to anticoagulant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040024 +name: trait in response to vincristine +def: "A trait that affects the response to a stimulus with vincristine." [] +synonym: "response to vincristine trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040025 +name: trait in response to cytarabine +def: "A trait that affects the response to a stimulus with cytarabine." [] +synonym: "response to cytarabine trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040026 +name: trait in response to doxorubicin +def: "A trait that affects the response to a stimulus with doxorubicin." [] +synonym: "response to doxorubicin trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040027 +name: trait in response to serotonin +def: "A trait that affects the response to a stimulus with serotonin." [] +synonym: "response to serotonin trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040028 +name: trait in response to melphalan +def: "A trait that affects the response to a stimulus with melphalan." [] +synonym: "response to melphalan trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040029 +name: trait in response to silicon dioxide +def: "A trait that affects the response to a stimulus with silicon dioxide." [] +synonym: "response to silicon dioxide trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040030 +name: trait in response to ethanol +def: "A trait that affects the response to a stimulus with ethanol." [] +synonym: "response to ethanol trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040031 +name: trait in response to aripiprazole +def: "A trait that affects the response to a stimulus with aripiprazole." [] +synonym: "response to aripiprazole trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040032 +name: trait in response to carboplatin +def: "A trait that affects the response to a stimulus with carboplatin." [] +synonym: "response to carboplatin trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040033 +name: trait in response to bupropion +def: "A trait that affects the response to a stimulus with bupropion." [] +synonym: "response to bupropion trait" EXACT [] +is_a: OBA:2040043 ! trait in response to antidepressant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040034 +name: trait in response to buspirone +def: "A trait that affects the response to a stimulus with buspirone." [] +synonym: "response to buspirone trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040035 +name: trait in response to vitamin +def: "A trait that affects the response to a stimulus with vitamin." [] +synonym: "response to vitamin trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040036 +name: trait in response to antimicrobial agent +def: "A trait that affects the response to a stimulus with antimicrobial agent." [] +synonym: "response to antimicrobial agent trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040037 +name: trait in response to platinum +def: "A trait that affects the response to a stimulus with platinum." [] +synonym: "response to platinum trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040038 +name: trait in response to candesartan +def: "A trait that affects the response to a stimulus with candesartan." [] +synonym: "response to candesartan trait" EXACT [] +is_a: OBA:2040097 ! trait in response to angiotensin receptor antagonist +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040039 +name: trait in response to carbamazepine +def: "A trait that affects the response to a stimulus with carbamazepine." [] +synonym: "response to carbamazepine trait" EXACT [] +is_a: OBA:2040050 ! trait in response to anticonvulsant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040040 +name: trait in response to antimetabolite +def: "A trait that affects the response to a stimulus with antimetabolite." [] +synonym: "response to antimetabolite trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040041 +name: trait in response to fatty acid +def: "A trait that affects the response to a stimulus with fatty acid." [] +synonym: "response to fatty acid trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040042 +name: trait in response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor +def: "A trait that affects the response to a stimulus with EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor." [] +synonym: "response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040043 +name: trait in response to antidepressant +def: "A trait that affects the response to a stimulus with antidepressant." [] +synonym: "response to antidepressant trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040044 +name: trait in response to non-steroidal anti-inflammatory drug +def: "A trait that affects the response to a stimulus with non-steroidal anti-inflammatory drug." [] +synonym: "response to non-steroidal anti-inflammatory drug trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040045 +name: trait in response to antipsychotic agent +def: "A trait that affects the response to a stimulus with antipsychotic agent." [] +synonym: "response to antipsychotic agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040046 +name: trait in response to diuretic +def: "A trait that affects the response to a stimulus with diuretic." [] +synonym: "response to diuretic trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040047 +name: trait in response to bronchodilator agent +def: "A trait that affects the response to a stimulus with bronchodilator agent." [] +synonym: "response to bronchodilator agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040048 +name: trait in response to beta-adrenergic antagonist +def: "A trait that affects the response to a stimulus with beta-adrenergic antagonist." [] +synonym: "response to beta-adrenergic antagonist trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040049 +name: trait in response to antineoplastic agent +def: "A trait that affects the response to a stimulus with antineoplastic agent." [] +synonym: "response to antineoplastic agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040050 +name: trait in response to anticonvulsant +def: "A trait that affects the response to a stimulus with anticonvulsant." [] +synonym: "response to anticonvulsant trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040051 +name: trait in response to thiopurine +def: "A trait that affects the response to a stimulus with thiopurine." [] +synonym: "response to thiopurine trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040052 +name: trait in response to immunosuppressive agent +def: "A trait that affects the response to a stimulus with immunosuppressive agent." [] +synonym: "response to immunosuppressive agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040053 +name: trait in response to antiviral drug +def: "A trait that affects the response to a stimulus with antiviral drug." [] +synonym: "response to antiviral drug trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040054 +name: trait in response to taxane +def: "A trait that affects the response to a stimulus with taxane." [] +synonym: "response to taxane trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040055 +name: trait in response to escitalopram +def: "A trait that affects the response to a stimulus with escitalopram." [] +synonym: "response to escitalopram trait" EXACT [] +is_a: OBA:2040043 ! trait in response to antidepressant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040056 +name: trait in response to duloxetine +def: "A trait that affects the response to a stimulus with duloxetine." [] +synonym: "response to duloxetine trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040057 +name: trait in response to citalopram +def: "A trait that affects the response to a stimulus with citalopram." [] +synonym: "response to citalopram trait" EXACT [] +is_a: OBA:2040043 ! trait in response to antidepressant +is_a: OBA:2040090 ! trait in response to serotonin uptake inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040058 +name: trait in response to clozapine +def: "A trait that affects the response to a stimulus with clozapine." [] +synonym: "response to clozapine trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040059 +name: trait in response to protease inhibitor +def: "A trait that affects the response to a stimulus with protease inhibitor." [] +synonym: "response to protease inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040060 +name: trait in response to EC 3.1.1.8 (cholinesterase) inhibitor +def: "A trait that affects the response to a stimulus with EC 3.1.1.8 (cholinesterase) inhibitor." [] +synonym: "response to EC 3.1.1.8 (cholinesterase) inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040061 +name: trait in response to growth hormone +def: "A trait that affects the response to a stimulus with growth hormone." [] +synonym: "response to growth hormone trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040062 +name: trait in response to clopidogrel +def: "A trait that affects the response to a stimulus with clopidogrel." [] +synonym: "response to clopidogrel trait" EXACT [] +is_a: OBA:2040082 ! trait in response to anticoagulant +is_a: OBA:2040084 ! trait in response to platelet aggregation inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040063 +name: trait in response to calcium channel blocker +def: "A trait that affects the response to a stimulus with calcium channel blocker." [] +synonym: "response to calcium channel blocker trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040064 +name: trait in response to tyrosine kinase inhibitor +def: "A trait that affects the response to a stimulus with tyrosine kinase inhibitor." [] +synonym: "response to tyrosine kinase inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040065 +name: trait in response to atorvastatin +def: "A trait that affects the response to a stimulus with atorvastatin." [] +synonym: "response to atorvastatin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040066 +name: trait in response to cyclophosphamide +def: "A trait that affects the response to a stimulus with cyclophosphamide." [] +synonym: "response to cyclophosphamide trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040067 +name: trait in response to allopurinol +def: "A trait that affects the response to a stimulus with allopurinol." [] +synonym: "response to allopurinol trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040040 ! trait in response to antimetabolite +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040068 +name: trait in response to cyclosporin A +def: "A trait that affects the response to a stimulus with cyclosporin A." [] +synonym: "response to cyclosporin A trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040069 +name: trait in response to tamoxifen +def: "A trait that affects the response to a stimulus with tamoxifen." [] +synonym: "response to tamoxifen trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040070 +name: trait in response to dexamethasone +def: "A trait that affects the response to a stimulus with dexamethasone." [] +synonym: "response to dexamethasone trait" EXACT [] +is_a: OBA:2040017 ! trait in response to glucocorticoid +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040071 +name: trait in response to abacavir +def: "A trait that affects the response to a stimulus with abacavir." [] +synonym: "response to abacavir trait" EXACT [] +is_a: OBA:2040053 ! trait in response to antiviral drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040072 +name: trait in response to methotrexate +def: "A trait that affects the response to a stimulus with methotrexate." [] +synonym: "response to methotrexate trait" EXACT [] +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040073 +name: trait in response to paclitaxel +def: "A trait that affects the response to a stimulus with paclitaxel." [] +synonym: "response to paclitaxel trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040074 +name: trait in response to 5-fluorouracil +def: "A trait that affects the response to a stimulus with 5-fluorouracil." [] +synonym: "response to 5-fluorouracil trait" EXACT [] +is_a: OBA:2040006 ! trait in response to radiosensitizing agent +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040075 +name: trait in response to diclofenac +def: "A trait that affects the response to a stimulus with diclofenac." [] +synonym: "response to diclofenac trait" EXACT [] +is_a: OBA:2040044 ! trait in response to non-steroidal anti-inflammatory drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040076 +name: trait in response to etoposide +def: "A trait that affects the response to a stimulus with etoposide." [] +synonym: "response to etoposide trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040077 +name: trait in response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor +def: "A trait that affects the response to a stimulus with EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor." [] +synonym: "response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040078 +name: trait in response to lapatinib +def: "A trait that affects the response to a stimulus with lapatinib." [] +synonym: "response to lapatinib trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040064 ! trait in response to tyrosine kinase inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040079 +name: trait in response to gefitinib +def: "A trait that affects the response to a stimulus with gefitinib." [] +synonym: "response to gefitinib trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040080 +name: trait in response to lithium(1+) +def: "A trait that affects the response to a stimulus with lithium(1+)." [] +synonym: "response to lithium(1+) trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040081 +name: trait in response to fenofibrate +def: "A trait that affects the response to a stimulus with fenofibrate." [] +synonym: "response to fenofibrate trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040082 +name: trait in response to anticoagulant +def: "A trait that affects the response to a stimulus with anticoagulant." [] +synonym: "response to anticoagulant trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040083 +name: trait in response to thiazide +def: "A trait that affects the response to a stimulus with thiazide." [] +synonym: "response to thiazide trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040084 +name: trait in response to platelet aggregation inhibitor +def: "A trait that affects the response to a stimulus with platelet aggregation inhibitor." [] +synonym: "response to platelet aggregation inhibitor trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040085 +name: trait in response to mercaptopurine +def: "A trait that affects the response to a stimulus with mercaptopurine." [] +synonym: "response to mercaptopurine trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040086 +name: trait in response to montelukast +def: "A trait that affects the response to a stimulus with montelukast." [] +synonym: "response to montelukast trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040087 +name: trait in response to EC 1.14.14.14 (aromatase) inhibitor +def: "A trait that affects the response to a stimulus with EC 1.14.14.14 (aromatase) inhibitor." [] +synonym: "response to EC 1.14.14.14 (aromatase) inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040088 +name: trait in response to corticosteroid +def: "A trait that affects the response to a stimulus with corticosteroid." [] +synonym: "response to corticosteroid trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040089 +name: trait in response to tetracyclic antidepressant +def: "A trait that affects the response to a stimulus with tetracyclic antidepressant." [] +synonym: "response to tetracyclic antidepressant trait" EXACT [] +is_a: OBA:2040043 ! trait in response to antidepressant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040090 +name: trait in response to serotonin uptake inhibitor +def: "A trait that affects the response to a stimulus with serotonin uptake inhibitor." [] +synonym: "response to serotonin uptake inhibitor trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040091 +name: trait in response to bortezomib +def: "A trait that affects the response to a stimulus with bortezomib." [] +synonym: "response to bortezomib trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040059 ! trait in response to protease inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040092 +name: trait in response to haloperidol +def: "A trait that affects the response to a stimulus with haloperidol." [] +synonym: "response to haloperidol trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040093 +name: trait in response to hydrochlorothiazide +def: "A trait that affects the response to a stimulus with hydrochlorothiazide." [] +synonym: "response to hydrochlorothiazide trait" EXACT [] +is_a: OBA:2040046 ! trait in response to diuretic +is_a: OBA:2040083 ! trait in response to thiazide +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040094 +name: trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +def: "A trait that affects the response to a stimulus with EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor." [] +synonym: "response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040095 +name: trait in response to opioid agent +def: "A trait that affects the response to a stimulus with opioid agent." [] +synonym: "response to opioid agent trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040096 +name: trait in response to floxuridine +def: "A trait that affects the response to a stimulus with floxuridine." [] +synonym: "response to floxuridine trait" EXACT [] +is_a: OBA:2040006 ! trait in response to radiosensitizing agent +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040053 ! trait in response to antiviral drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040097 +name: trait in response to angiotensin receptor antagonist +def: "A trait that affects the response to a stimulus with angiotensin receptor antagonist." [] +synonym: "response to angiotensin receptor antagonist trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040098 +name: trait in response to tacrolimus hydrate +def: "A trait that affects the response to a stimulus with tacrolimus hydrate." [] +synonym: "response to tacrolimus hydrate trait" EXACT [] +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040099 +name: trait in response to metamizole +def: "A trait that affects the response to a stimulus with metamizole." [] +synonym: "response to metamizole trait" EXACT [] +is_a: OBA:2040044 ! trait in response to non-steroidal anti-inflammatory drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040100 +name: trait in response to ribavirin +def: "A trait that affects the response to a stimulus with ribavirin." [] +synonym: "response to ribavirin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040094 ! trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040101 +name: trait in response to stavudine +def: "A trait that affects the response to a stimulus with stavudine." [] +synonym: "response to stavudine trait" EXACT [] +is_a: OBA:2040040 ! trait in response to antimetabolite +is_a: OBA:2040094 ! trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040102 +name: trait in response to sotalol +def: "A trait that affects the response to a stimulus with sotalol." [] +synonym: "response to sotalol trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040048 ! trait in response to beta-adrenergic antagonist +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040103 +name: trait in response to tenofovir (anhydrous) +def: "A trait that affects the response to a stimulus with tenofovir (anhydrous)." [] +synonym: "response to tenofovir (anhydrous) trait" EXACT [] +is_a: OBA:2040053 ! trait in response to antiviral drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040104 +name: trait in response to lamotrigine +def: "A trait that affects the response to a stimulus with lamotrigine." [] +synonym: "response to lamotrigine trait" EXACT [] +is_a: OBA:2040043 ! trait in response to antidepressant +is_a: OBA:2040050 ! trait in response to anticonvulsant +is_a: OBA:2040063 ! trait in response to calcium channel blocker +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040105 +name: trait in response to amisulpride +def: "A trait that affects the response to a stimulus with amisulpride." [] +synonym: "response to amisulpride trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040106 +name: trait in response to ximelagatran +def: "A trait that affects the response to a stimulus with ximelagatran." [] +synonym: "response to ximelagatran trait" EXACT [] +is_a: OBA:2040059 ! trait in response to protease inhibitor +is_a: OBA:2040082 ! trait in response to anticoagulant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040107 +name: trait in response to iloperidone +def: "A trait that affects the response to a stimulus with iloperidone." [] +synonym: "response to iloperidone trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040108 +name: trait in response to losartan +def: "A trait that affects the response to a stimulus with losartan." [] +synonym: "response to losartan trait" EXACT [] +is_a: OBA:2040097 ! trait in response to angiotensin receptor antagonist +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040109 +name: trait in response to ivacaftor +def: "A trait that affects the response to a stimulus with ivacaftor." [] +synonym: "response to ivacaftor trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040110 +name: trait in response to metformin +def: "A trait that affects the response to a stimulus with metformin." [] +synonym: "response to metformin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040111 +name: trait in response to mTOR inhibitor +def: "A trait that affects the response to a stimulus with mTOR inhibitor." [] +synonym: "response to mTOR inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040112 +name: trait in response to methylphenidate +def: "A trait that affects the response to a stimulus with methylphenidate." [] +synonym: "response to methylphenidate trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040113 +name: trait in response to topoisomerase inhibitor +def: "A trait that affects the response to a stimulus with topoisomerase inhibitor." [] +synonym: "response to topoisomerase inhibitor trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040114 +name: trait in response to dabigatran etexilate +def: "A trait that affects the response to a stimulus with dabigatran etexilate." [] +synonym: "response to dabigatran etexilate trait" EXACT [] +is_a: OBA:2040082 ! trait in response to anticoagulant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040115 +name: trait in response to omacetaxine mepesuccinate +def: "A trait that affects the response to a stimulus with omacetaxine mepesuccinate." [] +synonym: "response to omacetaxine mepesuccinate trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040116 +name: trait in response to tofacitinib +def: "A trait that affects the response to a stimulus with tofacitinib." [] +synonym: "response to tofacitinib trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040064 ! trait in response to tyrosine kinase inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040117 +name: trait in response to pazopanib +def: "A trait that affects the response to a stimulus with pazopanib." [] +synonym: "response to pazopanib trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040064 ! trait in response to tyrosine kinase inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040118 +name: trait in response to nitrofurantoin +def: "A trait that affects the response to a stimulus with nitrofurantoin." [] +synonym: "response to nitrofurantoin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040119 +name: trait in response to triamcinolone acetonide +def: "A trait that affects the response to a stimulus with triamcinolone acetonide." [] +synonym: "response to triamcinolone acetonide trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040017 ! trait in response to glucocorticoid +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040120 +name: trait in response to temozolomide +def: "A trait that affects the response to a stimulus with temozolomide." [] +synonym: "response to temozolomide trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040121 +name: trait in response to dabrafenib +def: "A trait that affects the response to a stimulus with dabrafenib." [] +synonym: "response to dabrafenib trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040122 +name: trait in response to trametinib +def: "A trait that affects the response to a stimulus with trametinib." [] +synonym: "response to trametinib trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040123 +name: trait in response to dimethyl fumarate +def: "A trait that affects the response to a stimulus with dimethyl fumarate." [] +synonym: "response to dimethyl fumarate trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040124 +name: trait in response to dolutegravir +def: "A trait that affects the response to a stimulus with dolutegravir." [] +synonym: "response to dolutegravir trait" EXACT [] +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040125 +name: trait in response to olanzapine +def: "A trait that affects the response to a stimulus with olanzapine." [] +synonym: "response to olanzapine trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +is_a: OBA:2040090 ! trait in response to serotonin uptake inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040126 +name: trait in response to oxcarbazepine +def: "A trait that affects the response to a stimulus with oxcarbazepine." [] +synonym: "response to oxcarbazepine trait" EXACT [] +is_a: OBA:2040050 ! trait in response to anticonvulsant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040127 +name: trait in response to perphenazine +def: "A trait that affects the response to a stimulus with perphenazine." [] +synonym: "response to perphenazine trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040128 +name: trait in response to irinotecan +def: "A trait that affects the response to a stimulus with irinotecan." [] +synonym: "response to irinotecan trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040113 ! trait in response to topoisomerase inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040129 +name: trait in response to phenylephrine +def: "A trait that affects the response to a stimulus with phenylephrine." [] +synonym: "response to phenylephrine trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040130 +name: trait in response to phenytoin +def: "A trait that affects the response to a stimulus with phenytoin." [] +synonym: "response to phenytoin trait" EXACT [] +is_a: OBA:2040050 ! trait in response to anticonvulsant +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040131 +name: trait in response to 4-(4-Hydroxyphenyl)-2-butanol +def: "A trait that affects the response to a stimulus with 4-(4-Hydroxyphenyl)-2-butanol." [] +synonym: "response to 4-(4-Hydroxyphenyl)-2-butanol trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040132 +name: trait in response to paliperidone +def: "A trait that affects the response to a stimulus with paliperidone." [] +synonym: "response to paliperidone trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040133 +name: trait in response to prednisolone +def: "A trait that affects the response to a stimulus with prednisolone." [] +synonym: "response to prednisolone trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040017 ! trait in response to glucocorticoid +is_a: OBA:2040049 ! trait in response to antineoplastic agent +is_a: OBA:2040052 ! trait in response to immunosuppressive agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040134 +name: trait in response to quetiapine +def: "A trait that affects the response to a stimulus with quetiapine." [] +synonym: "response to quetiapine trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040135 +name: trait in response to risperidone +def: "A trait that affects the response to a stimulus with risperidone." [] +synonym: "response to risperidone trait" EXACT [] +is_a: OBA:2040045 ! trait in response to antipsychotic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040136 +name: trait in response to simvastatin +def: "A trait that affects the response to a stimulus with simvastatin." [] +synonym: "response to simvastatin trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040059 ! trait in response to protease inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040137 +name: trait in response to sulfasalazine +def: "A trait that affects the response to a stimulus with sulfasalazine." [] +synonym: "response to sulfasalazine trait" EXACT [] +is_a: OBA:2040044 ! trait in response to non-steroidal anti-inflammatory drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040138 +name: trait in response to tamsulosin +def: "A trait that affects the response to a stimulus with tamsulosin." [] +synonym: "response to tamsulosin trait" EXACT [] +is_a: OBA:2040049 ! trait in response to antineoplastic agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040139 +name: trait in response to terbinafine +def: "A trait that affects the response to a stimulus with terbinafine." [] +synonym: "response to terbinafine trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +is_a: OBA:2040036 ! trait in response to antimicrobial agent +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040140 +name: trait in response to Triptolide +def: "A trait that affects the response to a stimulus with Triptolide." [] +synonym: "response to Triptolide trait" EXACT [] +is_a: OBA:0100002 ! biological process attribute +is_a: PATO:0001236 ! process quality +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040141 +name: trait in response to venlafaxine +def: "A trait that affects the response to a stimulus with venlafaxine." [] +synonym: "response to venlafaxine trait" EXACT [] +is_a: ENVO:09200002 ! environmental system process quality +is_a: OBA:2040043 ! trait in response to antidepressant +is_a: OBA:2040090 ! trait in response to serotonin uptake inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040153 +name: age of onset of cancer +def: "The age at which cancer manifestations first appear." [] +synonym: "age at onset of cancer" EXACT [] +synonym: "age cancer symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0004992 ! inheres in cancer +relationship: RO:0000052 MONDO:0004992 ! inheres in cancer + +[Term] +id: OBA:2040154 +name: age of onset of glaucoma +def: "The age at which glaucoma manifestations first appear." [] +synonym: "age at onset of glaucoma" EXACT [] +synonym: "age glaucoma symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005041 ! inheres in glaucoma +relationship: RO:0000052 MONDO:0005041 ! inheres in glaucoma + +[Term] +id: OBA:2040155 +name: age of onset of stroke disorder +def: "The age at which stroke disorder manifestations first appear." [] +synonym: "age at onset of stroke disorder" EXACT [] +synonym: "age stroke disorder symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005098 ! inheres in stroke disorder +relationship: RO:0000052 MONDO:0005098 ! inheres in stroke disorder + +[Term] +id: OBA:2040156 +name: age of onset of coronary stenosis +def: "The age at which coronary stenosis manifestations first appear." [] +synonym: "age at onset of coronary stenosis" EXACT [] +synonym: "age coronary stenosis symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0006715 ! inheres in coronary stenosis +relationship: RO:0000052 MONDO:0006715 ! inheres in coronary stenosis + +[Term] +id: OBA:2040157 +name: age of onset of glioblastoma +def: "The age at which glioblastoma manifestations first appear." [] +synonym: "age at onset of glioblastoma" EXACT [] +synonym: "age glioblastoma symptoms begin" EXACT [] +is_a: OBA:2040153 ! age of onset of cancer +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0018177 ! inheres in glioblastoma +relationship: RO:0000052 MONDO:0018177 ! inheres in glioblastoma + +[Term] +id: OBA:2040158 +name: age of onset of systemic lupus erythematosus +def: "The age at which systemic lupus erythematosus manifestations first appear." [] +synonym: "age at onset of systemic lupus erythematosus" EXACT [] +synonym: "age systemic lupus erythematosus symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0007915 ! inheres in systemic lupus erythematosus +relationship: RO:0000052 MONDO:0007915 ! inheres in systemic lupus erythematosus + +[Term] +id: OBA:2040159 +name: age of onset of hypertensive disorder +def: "The age at which hypertensive disorder manifestations first appear." [] +synonym: "age at onset of hypertensive disorder" EXACT [] +synonym: "age hypertensive disorder symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0005044 ! inheres in hypertensive disorder +relationship: RO:0000052 MONDO:0005044 ! inheres in hypertensive disorder + +[Term] +id: OBA:2040160 +name: age of onset of Machado-Joseph disease +def: "The age at which Machado-Joseph disease manifestations first appear." [] +synonym: "age at onset of Machado-Joseph disease" EXACT [] +synonym: "age Machado-Joseph disease symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0007182 ! inheres in Machado-Joseph disease +relationship: RO:0000052 MONDO:0007182 ! inheres in Machado-Joseph disease + +[Term] +id: OBA:2040161 +name: age of onset of major depressive disorder +def: "The age at which major depressive disorder manifestations first appear." [] +synonym: "age at onset of major depressive disorder" EXACT [] +synonym: "age major depressive disorder symptoms begin" EXACT [] +is_a: HP:0003674 ! Onset +intersection_of: HP:0003674 ! Onset +intersection_of: RO:0000052 MONDO:0002009 ! inheres in major depressive disorder +relationship: RO:0000052 MONDO:0002009 ! inheres in major depressive disorder + +[Term] +id: OBA:2040162 +name: trait in response to methamphetamine +def: "A trait that affects the response to a stimulus with methamphetamine." [] +synonym: "response to methamphetamine trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040163 +name: trait in response to cocaine +def: "A trait that affects the response to a stimulus with cocaine." [] +synonym: "response to cocaine trait" EXACT [] +is_a: OBA:2040090 ! trait in response to serotonin uptake inhibitor +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string + +[Term] +id: OBA:2040164 +name: trait in response to nicotine +def: "A trait that affects the response to a stimulus with nicotine." [] +synonym: "response to nicotine trait" EXACT [] +is_a: OBA:2040016 ! trait in response to drug +property_value: dc-contributor https://orcid.org/0000-0001-8314-2140 xsd:string +property_value: dc-contributor https://orcid.org/0000-0002-7073-9172 xsd:string [Term] id: OBA:VT0000000 @@ -169699,8 +270850,8 @@ synonym: "morphology of mammary gland fluid/secretion" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006539 ! mammary gland fluid/secretion -relationship: inheres_in UBERON:0006539 ! mammary gland fluid/secretion +intersection_of: RO:0000052 UBERON:0006539 ! inheres in mammary gland fluid/secretion +relationship: RO:0000052 UBERON:0006539 ! inheres in mammary gland fluid/secretion [Term] id: OBA:VT0000002 @@ -169710,7 +270861,7 @@ synonym: "size of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000432 ! head morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0000003 @@ -169719,8 +270870,8 @@ def: "The morphology of a adipose tissue." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001013 ! adipose tissue -relationship: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue +relationship: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:VT0000005 @@ -169730,7 +270881,7 @@ synonym: "size of right cardiac atrium" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000019 ! right atrium morphology trait is_a: OBA:VT0003140 ! heart atrium size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002078 ! right cardiac atrium +intersection_of: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium [Term] id: OBA:VT0000006 @@ -169740,7 +270891,7 @@ synonym: "size of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000467 ! esophagus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:VT0000010 @@ -169749,8 +270900,8 @@ def: "The morphology of a abdominal fat pad." [AUTO:patterns/patterns/entity_att synonym: "morphology of abdominal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003427 ! abdominal fat pad -relationship: inheres_in UBERON:0003427 ! abdominal fat pad +intersection_of: RO:0000052 UBERON:0003427 ! inheres in abdominal fat pad +relationship: RO:0000052 UBERON:0003427 ! inheres in abdominal fat pad [Term] id: OBA:VT0000012 @@ -169760,7 +270911,7 @@ synonym: "size of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000020 ! left atrium morphology trait is_a: OBA:VT0003140 ! heart atrium size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:VT0000013 @@ -169770,7 +270921,7 @@ synonym: "spatial pattern of adipose tissue" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000003 ! adipose morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:VT0000017 @@ -169780,7 +270931,7 @@ synonym: "size of external ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0002845 ! external ear morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:VT0000018 @@ -169789,8 +270940,8 @@ def: "The morphology of a interventricular septum membranous part." [AUTO:patter synonym: "morphology of interventricular septum membranous part" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004666 ! interventricular septum membranous part -relationship: inheres_in UBERON:0004666 ! interventricular septum membranous part +intersection_of: RO:0000052 UBERON:0004666 ! inheres in interventricular septum membranous part +relationship: RO:0000052 UBERON:0004666 ! inheres in interventricular septum membranous part [Term] id: OBA:VT0000019 @@ -169799,8 +270950,8 @@ def: "The morphology of a right cardiac atrium." [AUTO:patterns/patterns/entity_ synonym: "morphology of right cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003105 ! heart atrium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002078 ! right cardiac atrium -relationship: inheres_in UBERON:0002078 ! right cardiac atrium +intersection_of: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium +relationship: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium [Term] id: OBA:VT0000020 @@ -169809,8 +270960,8 @@ def: "The morphology of a left cardiac atrium." [AUTO:patterns/patterns/entity_a synonym: "morphology of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003105 ! heart atrium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium -relationship: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium +relationship: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:VT0000022 @@ -169820,7 +270971,7 @@ synonym: "shape of external ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002845 ! external ear morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:VT0000024 @@ -169830,8 +270981,8 @@ synonym: "morphology of atrium auricular region" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006618 ! atrium auricular region -relationship: inheres_in UBERON:0006618 ! atrium auricular region +intersection_of: RO:0000052 UBERON:0006618 ! inheres in atrium auricular region +relationship: RO:0000052 UBERON:0006618 ! inheres in atrium auricular region [Term] id: OBA:VT0000025 @@ -169840,8 +270991,8 @@ def: "The morphology of a atrioventricular valve." [AUTO:patterns/patterns/entit synonym: "morphology of atrioventricular valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002133 ! atrioventricular valve -relationship: inheres_in UBERON:0002133 ! atrioventricular valve +intersection_of: RO:0000052 UBERON:0002133 ! inheres in atrioventricular valve +relationship: RO:0000052 UBERON:0002133 ! inheres in atrioventricular valve [Term] id: OBA:VT0000026 @@ -169851,8 +271002,8 @@ synonym: "morphology of internal ear" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001846 ! internal ear -relationship: inheres_in UBERON:0001846 ! internal ear +intersection_of: RO:0000052 UBERON:0001846 ! inheres in internal ear +relationship: RO:0000052 UBERON:0001846 ! inheres in internal ear [Term] id: OBA:VT0000027 @@ -169862,7 +271013,7 @@ synonym: "width of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000002 ! head size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0000028 @@ -169872,8 +271023,8 @@ synonym: "morphology of superior part of vestibular ganglion" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002825 ! superior part of vestibular ganglion -relationship: inheres_in UBERON:0002825 ! superior part of vestibular ganglion +intersection_of: RO:0000052 UBERON:0002825 ! inheres in superior part of vestibular ganglion +relationship: RO:0000052 UBERON:0002825 ! inheres in superior part of vestibular ganglion [Term] id: OBA:VT0000029 @@ -169884,7 +271035,7 @@ is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000186 ! malleus bone quality is_a: OBA:VT0005105 ! auditory ossicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001689 ! malleus bone +intersection_of: RO:0000052 UBERON:0001689 ! inheres in malleus bone [Term] id: OBA:VT0000030 @@ -169893,8 +271044,8 @@ def: "The morphology of a tympanic ring." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of tympanic ring" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002218 ! tympanic ring -relationship: inheres_in UBERON:0002218 ! tympanic ring +intersection_of: RO:0000052 UBERON:0002218 ! inheres in tympanic ring +relationship: RO:0000052 UBERON:0002218 ! inheres in tympanic ring [Term] id: OBA:VT0000031 @@ -169904,8 +271055,8 @@ synonym: "morphology of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001844 ! cochlea -relationship: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea +relationship: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:VT0000033 @@ -169914,8 +271065,8 @@ def: "The morphology of a mitral valve." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of mitral valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000025 ! atrioventricular valve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002135 ! mitral valve -relationship: inheres_in UBERON:0002135 ! mitral valve +intersection_of: RO:0000052 UBERON:0002135 ! inheres in mitral valve +relationship: RO:0000052 UBERON:0002135 ! inheres in mitral valve [Term] id: OBA:VT0000034 @@ -169925,8 +271076,8 @@ synonym: "morphology of externally connecting tube lumen" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001349 ! externally connecting tube lumen -relationship: inheres_in UBERON:0001349 ! externally connecting tube lumen +intersection_of: RO:0000052 UBERON:0001349 ! inheres in externally connecting tube lumen +relationship: RO:0000052 UBERON:0001349 ! inheres in externally connecting tube lumen [Term] id: OBA:VT0000035 @@ -169936,7 +271087,7 @@ synonym: "morphology of membranous labyrinth" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000842 ! membranous labyrinth quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001849 ! membranous labyrinth +intersection_of: RO:0000052 UBERON:0001849 ! inheres in membranous labyrinth [Term] id: OBA:VT0000036 @@ -169945,8 +271096,8 @@ def: "The morphology of a tricuspid valve." [AUTO:patterns/patterns/entity_attri synonym: "morphology of tricuspid valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000025 ! atrioventricular valve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002134 ! tricuspid valve -relationship: inheres_in UBERON:0002134 ! tricuspid valve +intersection_of: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve +relationship: RO:0000052 UBERON:0002134 ! inheres in tricuspid valve [Term] id: OBA:VT0000037 @@ -169956,7 +271107,7 @@ synonym: "morphology of lateral semicircular canal" EXACT [AUTO:patterns/pattern is_a: OBA:1000835 ! lateral semicircular canal quality is_a: OBA:VT0002428 ! semicircular canal morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001843 ! lateral semicircular canal +intersection_of: RO:0000052 UBERON:0001843 ! inheres in lateral semicircular canal [Term] id: OBA:VT0000038 @@ -169966,7 +271117,7 @@ synonym: "length of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000002 ! head size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0000039 @@ -169976,8 +271127,8 @@ synonym: "morphology of otic capsule" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004637 ! otic capsule -relationship: inheres_in UBERON:0004637 ! otic capsule +intersection_of: RO:0000052 UBERON:0004637 ! inheres in otic capsule +relationship: RO:0000052 UBERON:0004637 ! inheres in otic capsule [Term] id: OBA:VT0000040 @@ -169986,8 +271137,8 @@ def: "The morphology of a aortic valve." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of aortic valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002746 ! semilunar valve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002137 ! aortic valve -relationship: inheres_in UBERON:0002137 ! aortic valve +intersection_of: RO:0000052 UBERON:0002137 ! inheres in aortic valve +relationship: RO:0000052 UBERON:0002137 ! inheres in aortic valve [Term] id: OBA:VT0000041 @@ -169997,7 +271148,7 @@ synonym: "size of endolymphatic duct" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000172 ! tube size is_a: OBA:VT0006011 ! endolymphatic duct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001860 ! endolymphatic duct +intersection_of: RO:0000052 UBERON:0001860 ! inheres in endolymphatic duct [Term] id: OBA:VT0000042 @@ -170007,8 +271158,8 @@ synonym: "morphology of spiral organ of cochlea" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002227 ! spiral organ of cochlea -relationship: inheres_in UBERON:0002227 ! spiral organ of cochlea +intersection_of: RO:0000052 UBERON:0002227 ! inheres in spiral organ of cochlea +relationship: RO:0000052 UBERON:0002227 ! inheres in spiral organ of cochlea [Term] id: OBA:VT0000044 @@ -170017,8 +271168,8 @@ def: "The morphology of a pulmonary valve." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pulmonary valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002746 ! semilunar valve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002146 ! pulmonary valve -relationship: inheres_in UBERON:0002146 ! pulmonary valve +intersection_of: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve +relationship: RO:0000052 UBERON:0002146 ! inheres in pulmonary valve [Term] id: OBA:VT0000045 @@ -170027,8 +271178,8 @@ def: "The morphology of a sensory hair cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of sensory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000855 ! sensory hair cell -relationship: inheres_in CL:0000855 ! sensory hair cell +intersection_of: RO:0000052 CL:0000855 ! inheres in sensory hair cell +relationship: RO:0000052 CL:0000855 ! inheres in sensory hair cell [Term] id: OBA:VT0000046 @@ -170038,8 +271189,8 @@ synonym: "morphology of sulcus ampullaris" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009038 ! sulcus ampullaris -relationship: inheres_in UBERON:0009038 ! sulcus ampullaris +intersection_of: RO:0000052 UBERON:0009038 ! inheres in sulcus ampullaris +relationship: RO:0000052 UBERON:0009038 ! inheres in sulcus ampullaris [Term] id: OBA:VT0000047 @@ -170049,7 +271200,7 @@ synonym: "circumference of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000002 ! head size trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0000048 @@ -170059,7 +271210,7 @@ synonym: "morphology of stria vascularis of cochlear duct" EXACT [AUTO:patterns/ is_a: OBA:1000851 ! stria vascularis of cochlear duct quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002282 ! stria vascularis of cochlear duct +intersection_of: RO:0000052 UBERON:0002282 ! inheres in stria vascularis of cochlear duct [Term] id: OBA:VT0000049 @@ -170069,8 +271220,8 @@ synonym: "morphology of middle ear" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001756 ! middle ear -relationship: inheres_in UBERON:0001756 ! middle ear +intersection_of: RO:0000052 UBERON:0001756 ! inheres in middle ear +relationship: RO:0000052 UBERON:0001756 ! inheres in middle ear [Term] id: OBA:VT0000051 @@ -170080,8 +271231,8 @@ synonym: "functionality of testis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:VT0000056 @@ -170090,8 +271241,8 @@ def: "The quality when measured in urine." [AUTO:patterns/patterns/attribute_loc synonym: "urine quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001088 ! urine -relationship: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine +relationship: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:VT0000057 @@ -170100,8 +271251,8 @@ def: "The quality of a ossification." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ossification" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001503 ! ossification -relationship: inheres_in GO:0001503 ! ossification +intersection_of: RO:0000052 GO:0001503 ! inheres in ossification +relationship: RO:0000052 GO:0001503 ! inheres in ossification [Term] id: OBA:VT0000058 @@ -170110,8 +271261,8 @@ def: "The morphology of a myocardial compact layer." [AUTO:patterns/patterns/ent synonym: "morphology of myocardial compact layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004125 ! myocardial compact layer -relationship: inheres_in UBERON:0004125 ! myocardial compact layer +intersection_of: RO:0000052 UBERON:0004125 ! inheres in myocardial compact layer +relationship: RO:0000052 UBERON:0004125 ! inheres in myocardial compact layer [Term] id: OBA:VT0000059 @@ -170120,8 +271271,8 @@ def: "The quality of a osteoclast development." [AUTO:patterns/patterns/entity_a synonym: "quality of osteoclast development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001601 ! myelopoiesis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0036035 ! osteoclast development -relationship: inheres_in GO:0036035 ! osteoclast development +intersection_of: RO:0000052 GO:0036035 ! inheres in osteoclast development +relationship: RO:0000052 GO:0036035 ! inheres in osteoclast development [Term] id: OBA:VT0000061 @@ -170130,8 +271281,8 @@ def: "The morphology of a cardiac muscle cell." [AUTO:patterns/patterns/entity_a synonym: "morphology of cardiac muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004087 ! muscle cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell -relationship: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell +relationship: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:VT0000062 @@ -170140,8 +271291,8 @@ def: "The morphology of a myocardium trabecular layer." [AUTO:patterns/patterns/ synonym: "morphology of myocardium trabecular layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004124 ! myocardium trabecular layer -relationship: inheres_in UBERON:0004124 ! myocardium trabecular layer +intersection_of: RO:0000052 UBERON:0004124 ! inheres in myocardium trabecular layer +relationship: RO:0000052 UBERON:0004124 ! inheres in myocardium trabecular layer [Term] id: OBA:VT0000063 @@ -170151,8 +271302,8 @@ synonym: "morphology of papillary muscle of heart" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002494 ! papillary muscle of heart -relationship: inheres_in UBERON:0002494 ! papillary muscle of heart +intersection_of: RO:0000052 UBERON:0002494 ! inheres in papillary muscle of heart +relationship: RO:0000052 UBERON:0002494 ! inheres in papillary muscle of heart [Term] id: OBA:VT0000065 @@ -170162,8 +271313,8 @@ synonym: "morphology of bone marrow cavity" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002484 ! bone marrow cavity -relationship: inheres_in UBERON:0002484 ! bone marrow cavity +intersection_of: RO:0000052 UBERON:0002484 ! inheres in bone marrow cavity +relationship: RO:0000052 UBERON:0002484 ! inheres in bone marrow cavity [Term] id: OBA:VT0000067 @@ -170173,8 +271324,8 @@ synonym: "morphology of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:VT0000068 @@ -170190,8 +271341,8 @@ def: "The quality when measured in embryo." [AUTO:patterns/patterns/attribute_lo synonym: "embryo quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0010454 ! organism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000922 ! embryo -relationship: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo +relationship: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:VT0000072 @@ -170201,8 +271352,8 @@ synonym: "elasticity of bone element" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001031 ! elasticity intersection_of: PATO:0001031 ! elasticity -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:VT0000074 @@ -170212,8 +271363,8 @@ synonym: "morphology of neurocranium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001703 ! neurocranium -relationship: inheres_in UBERON:0001703 ! neurocranium +intersection_of: RO:0000052 UBERON:0001703 ! inheres in neurocranium +relationship: RO:0000052 UBERON:0001703 ! inheres in neurocranium [Term] id: OBA:VT0000075 @@ -170223,8 +271374,8 @@ synonym: "morphology of blood brain barrier" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000120 ! blood brain barrier -relationship: inheres_in UBERON:0000120 ! blood brain barrier +intersection_of: RO:0000052 UBERON:0000120 ! inheres in blood brain barrier +relationship: RO:0000052 UBERON:0000120 ! inheres in blood brain barrier [Term] id: OBA:VT0000076 @@ -170234,8 +271385,8 @@ synonym: "morphology of vault of skull" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004339 ! vault of skull -relationship: inheres_in UBERON:0004339 ! vault of skull +intersection_of: RO:0000052 UBERON:0004339 ! inheres in vault of skull +relationship: RO:0000052 UBERON:0004339 ! inheres in vault of skull [Term] id: OBA:VT0000077 @@ -170245,8 +271396,8 @@ synonym: "morphology of interparietal bone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002229 ! interparietal bone -relationship: inheres_in UBERON:0002229 ! interparietal bone +intersection_of: RO:0000052 UBERON:0002229 ! inheres in interparietal bone +relationship: RO:0000052 UBERON:0002229 ! inheres in interparietal bone [Term] id: OBA:VT0000078 @@ -170256,8 +271407,8 @@ synonym: "morphology of supraoccipital bone" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004747 ! supraoccipital bone -relationship: inheres_in UBERON:0004747 ! supraoccipital bone +intersection_of: RO:0000052 UBERON:0004747 ! inheres in supraoccipital bone +relationship: RO:0000052 UBERON:0004747 ! inheres in supraoccipital bone [Term] id: OBA:VT0000079 @@ -170267,8 +271418,8 @@ synonym: "morphology of basioccipital bone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001692 ! basioccipital bone -relationship: inheres_in UBERON:0001692 ! basioccipital bone +intersection_of: RO:0000052 UBERON:0001692 ! inheres in basioccipital bone +relationship: RO:0000052 UBERON:0001692 ! inheres in basioccipital bone [Term] id: OBA:VT0000080 @@ -170278,8 +271429,8 @@ synonym: "morphology of exoccipital bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001693 ! exoccipital bone -relationship: inheres_in UBERON:0001693 ! exoccipital bone +intersection_of: RO:0000052 UBERON:0001693 ! inheres in exoccipital bone +relationship: RO:0000052 UBERON:0001693 ! inheres in exoccipital bone [Term] id: OBA:VT0000084 @@ -170287,9 +271438,9 @@ name: fontanelle morphology trait def: "The morphology of a fontanelle." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of fontanelle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000350 ! fontanelle quality -is_a: PATO:0000051 ! morphology +is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002221 ! fontanelle +intersection_of: RO:0000052 UBERON:0002221 ! inheres in fontanelle [Term] id: OBA:VT0000085 @@ -170299,8 +271450,8 @@ synonym: "morphology of blood-cerebrospinal fluid barrier" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003210 ! blood-cerebrospinal fluid barrier -relationship: inheres_in UBERON:0003210 ! blood-cerebrospinal fluid barrier +intersection_of: RO:0000052 UBERON:0003210 ! inheres in blood-cerebrospinal fluid barrier +relationship: RO:0000052 UBERON:0003210 ! inheres in blood-cerebrospinal fluid barrier [Term] id: OBA:VT0000087 @@ -170309,8 +271460,8 @@ def: "The morphology of a capillary." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of capillary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001982 ! capillary -relationship: inheres_in UBERON:0001982 ! capillary +intersection_of: RO:0000052 UBERON:0001982 ! inheres in capillary +relationship: RO:0000052 UBERON:0001982 ! inheres in capillary [Term] id: OBA:VT0000098 @@ -170320,8 +271471,8 @@ synonym: "morphology of vomer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002396 ! vomer -relationship: inheres_in UBERON:0002396 ! vomer +intersection_of: RO:0000052 UBERON:0002396 ! inheres in vomer +relationship: RO:0000052 UBERON:0002396 ! inheres in vomer [Term] id: OBA:VT0000100 @@ -170331,8 +271482,8 @@ synonym: "morphology of ethmoid bone" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001679 ! ethmoid bone -relationship: inheres_in UBERON:0001679 ! ethmoid bone +intersection_of: RO:0000052 UBERON:0001679 ! inheres in ethmoid bone +relationship: RO:0000052 UBERON:0001679 ! inheres in ethmoid bone [Term] id: OBA:VT0000102 @@ -170343,7 +271494,7 @@ is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000454 ! nasal bone quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001681 ! nasal bone +intersection_of: RO:0000052 UBERON:0001681 ! inheres in nasal bone [Term] id: OBA:VT0000104 @@ -170353,8 +271504,8 @@ synonym: "morphology of sphenoid bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001677 ! sphenoid bone -relationship: inheres_in UBERON:0001677 ! sphenoid bone +intersection_of: RO:0000052 UBERON:0001677 ! inheres in sphenoid bone +relationship: RO:0000052 UBERON:0001677 ! inheres in sphenoid bone [Term] id: OBA:VT0000106 @@ -170364,8 +271515,8 @@ synonym: "morphology of basisphenoid bone" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006428 ! basisphenoid bone -relationship: inheres_in UBERON:0006428 ! basisphenoid bone +intersection_of: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone +relationship: RO:0000052 UBERON:0006428 ! inheres in basisphenoid bone [Term] id: OBA:VT0000107 @@ -170375,8 +271526,8 @@ synonym: "morphology of tetrapod frontal bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000209 ! tetrapod frontal bone -relationship: inheres_in UBERON:0000209 ! tetrapod frontal bone +intersection_of: RO:0000052 UBERON:0000209 ! inheres in tetrapod frontal bone +relationship: RO:0000052 UBERON:0000209 ! inheres in tetrapod frontal bone [Term] id: OBA:VT0000109 @@ -170386,7 +271537,7 @@ synonym: "morphology of tetrapod parietal bone" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000520 ! tetrapod parietal bone quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000210 ! tetrapod parietal bone +intersection_of: RO:0000052 UBERON:0000210 ! inheres in tetrapod parietal bone [Term] id: OBA:VT0000116 @@ -170395,8 +271546,8 @@ def: "The quality of a odontogenesis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of odontogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042476 ! odontogenesis -relationship: inheres_in GO:0042476 ! odontogenesis +intersection_of: RO:0000052 GO:0042476 ! inheres in odontogenesis +relationship: RO:0000052 GO:0042476 ! inheres in odontogenesis [Term] id: OBA:VT0000119 @@ -170405,8 +271556,8 @@ def: "The quality of a tooth eruption." [AUTO:patterns/patterns/entity_attribute synonym: "quality of tooth eruption" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0044691 ! tooth eruption -relationship: inheres_in GO:0044691 ! tooth eruption +intersection_of: RO:0000052 GO:0044691 ! inheres in tooth eruption +relationship: RO:0000052 GO:0044691 ! inheres in tooth eruption [Term] id: OBA:VT0000121 @@ -170415,8 +271566,8 @@ def: "The quality of a http://purl.obolibrary.org/obo/GO_0072358." [AUTO:pattern synonym: "quality of http://purl.obolibrary.org/obo/GO_0072358" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072358 -relationship: inheres_in GO:0072358 +intersection_of: RO:0000052 GO:0072358 ! inheres in +relationship: RO:0000052 GO:0072358 ! inheres in [Term] id: OBA:VT0000122 @@ -170425,8 +271576,8 @@ def: "The quality of a blood vessel development." [AUTO:patterns/patterns/entity synonym: "quality of blood vessel development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001568 ! blood vessel development -relationship: inheres_in GO:0001568 ! blood vessel development +intersection_of: RO:0000052 GO:0001568 ! inheres in blood vessel development +relationship: RO:0000052 GO:0001568 ! inheres in blood vessel development [Term] id: OBA:VT0000124 @@ -170436,8 +271587,8 @@ synonym: "has number of of calcareous tooth" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth -relationship: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth +relationship: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:VT0000125 @@ -170446,8 +271597,8 @@ def: "The morphology of a heart tube." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of heart tube" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004141 ! heart tube -relationship: inheres_in UBERON:0004141 ! heart tube +intersection_of: RO:0000052 UBERON:0004141 ! inheres in heart tube +relationship: RO:0000052 UBERON:0004141 ! inheres in heart tube [Term] id: OBA:VT0000126 @@ -170457,8 +271608,8 @@ synonym: "strength of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth -relationship: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth +relationship: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:VT0000130 @@ -170467,8 +271618,8 @@ def: "The morphology of a trabecular bone tissue." [AUTO:patterns/patterns/entit synonym: "morphology of trabecular bone tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002483 ! trabecular bone tissue -relationship: inheres_in UBERON:0002483 ! trabecular bone tissue +intersection_of: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue +relationship: RO:0000052 UBERON:0002483 ! inheres in trabecular bone tissue [Term] id: OBA:VT0000131 @@ -170478,8 +271629,8 @@ synonym: "morphology of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001437 ! epiphysis -relationship: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis +relationship: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:VT0000132 @@ -170489,7 +271640,7 @@ synonym: "width of epiphysis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003163 ! epiphysis size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001437 ! epiphysis +intersection_of: RO:0000052 UBERON:0001437 ! inheres in epiphysis [Term] id: OBA:VT0000133 @@ -170499,8 +271650,8 @@ synonym: "morphology of metaphysis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001438 ! metaphysis -relationship: inheres_in UBERON:0001438 ! metaphysis +intersection_of: RO:0000052 UBERON:0001438 ! inheres in metaphysis +relationship: RO:0000052 UBERON:0001438 ! inheres in metaphysis [Term] id: OBA:VT0000134 @@ -170510,7 +271661,7 @@ synonym: "thickness of compact bone tissue" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0002354 ! compact bone tissue size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001439 ! compact bone tissue +intersection_of: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue [Term] id: OBA:VT0000135 @@ -170520,8 +271671,8 @@ synonym: "morphology of outflow tract" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004145 ! outflow tract -relationship: inheres_in UBERON:0004145 ! outflow tract +intersection_of: RO:0000052 UBERON:0004145 ! inheres in outflow tract +relationship: RO:0000052 UBERON:0004145 ! inheres in outflow tract [Term] id: OBA:VT0000136 @@ -170532,7 +271683,7 @@ is_a: OBA:1000564 ! microglial cell quality is_a: OBA:VT0002446 ! macrophage morphology trait is_a: OBA:VT0003634 ! glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000129 ! microglial cell +intersection_of: RO:0000052 CL:0000129 ! inheres in microglial cell [Term] id: OBA:VT0000137 @@ -170541,8 +271692,8 @@ def: "The morphology of a vertebra." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002412 ! vertebra -relationship: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra +relationship: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:VT0000138 @@ -170552,8 +271703,8 @@ synonym: "has number of of vertebra" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002412 ! vertebra -relationship: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra +relationship: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:VT0000139 @@ -170563,8 +271714,8 @@ synonym: "morphology of parapophysis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000675 ! transverse process of vertebra quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003109 ! parapophysis -relationship: inheres_in UBERON:0003109 ! parapophysis +intersection_of: RO:0000052 UBERON:0003109 ! inheres in parapophysis +relationship: RO:0000052 UBERON:0003109 ! inheres in parapophysis [Term] id: OBA:VT0000140 @@ -170574,8 +271725,8 @@ synonym: "morphology of pedicle of vertebra" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001078 ! pedicle of vertebra -relationship: inheres_in UBERON:0001078 ! pedicle of vertebra +intersection_of: RO:0000052 UBERON:0001078 ! inheres in pedicle of vertebra +relationship: RO:0000052 UBERON:0001078 ! inheres in pedicle of vertebra [Term] id: OBA:VT0000141 @@ -170584,8 +271735,8 @@ def: "The morphology of a bony vertebral centrum." [AUTO:patterns/patterns/entit synonym: "morphology of bony vertebral centrum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001075 ! bony vertebral centrum -relationship: inheres_in UBERON:0001075 ! bony vertebral centrum +intersection_of: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum +relationship: RO:0000052 UBERON:0001075 ! inheres in bony vertebral centrum [Term] id: OBA:VT0000142 @@ -170595,7 +271746,7 @@ synonym: "thickness of external ear" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000017 ! outer ear size trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:VT0000149 @@ -170605,8 +271756,8 @@ synonym: "morphology of scapula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006849 ! scapula -relationship: inheres_in UBERON:0006849 ! scapula +intersection_of: RO:0000052 UBERON:0006849 ! inheres in scapula +relationship: RO:0000052 UBERON:0006849 ! inheres in scapula [Term] id: OBA:VT0000150 @@ -170616,7 +271767,7 @@ synonym: "morphology of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000534 ! rib quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:VT0000152 @@ -170626,8 +271777,8 @@ synonym: "morphology of proximal segment of rib" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010388 ! proximal segment of rib -relationship: inheres_in UBERON:0010388 ! proximal segment of rib +intersection_of: RO:0000052 UBERON:0010388 ! inheres in proximal segment of rib +relationship: RO:0000052 UBERON:0010388 ! inheres in proximal segment of rib [Term] id: OBA:VT0000157 @@ -170637,8 +271788,8 @@ synonym: "morphology of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000975 ! sternum -relationship: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum +relationship: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:VT0000159 @@ -170648,7 +271799,7 @@ synonym: "morphology of xiphoid process" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000594 ! xiphoid process quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002207 ! xiphoid process +intersection_of: RO:0000052 UBERON:0002207 ! inheres in xiphoid process [Term] id: OBA:VT0000163 @@ -170657,8 +271808,8 @@ def: "The morphology of a cartilage tissue." [AUTO:patterns/patterns/entity_attr synonym: "morphology of cartilage tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002418 ! cartilage tissue -relationship: inheres_in UBERON:0002418 ! cartilage tissue +intersection_of: RO:0000052 UBERON:0002418 ! inheres in cartilage tissue +relationship: RO:0000052 UBERON:0002418 ! inheres in cartilage tissue [Term] id: OBA:VT0000164 @@ -170667,8 +271818,8 @@ def: "The quality of a cartilage development." [AUTO:patterns/patterns/entity_at synonym: "quality of cartilage development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0051216 ! cartilage development -relationship: inheres_in GO:0051216 ! cartilage development +intersection_of: RO:0000052 GO:0051216 ! inheres in cartilage development +relationship: RO:0000052 GO:0051216 ! inheres in cartilage development [Term] id: OBA:VT0000165 @@ -170677,8 +271828,8 @@ def: "The morphology of a long bone epiphyseal plate hypertrophic zone." [AUTO:p synonym: "morphology of long bone epiphyseal plate hypertrophic zone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006772 ! long bone epiphyseal plate hypertrophic zone -relationship: inheres_in UBERON:0006772 ! long bone epiphyseal plate hypertrophic zone +intersection_of: RO:0000052 UBERON:0006772 ! inheres in long bone epiphyseal plate hypertrophic zone +relationship: RO:0000052 UBERON:0006772 ! inheres in long bone epiphyseal plate hypertrophic zone [Term] id: OBA:VT0000166 @@ -170687,8 +271838,8 @@ def: "The morphology of a chondrocyte." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of chondrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000138 ! chondrocyte -relationship: inheres_in CL:0000138 ! chondrocyte +intersection_of: RO:0000052 CL:0000138 ! inheres in chondrocyte +relationship: RO:0000052 CL:0000138 ! inheres in chondrocyte [Term] id: OBA:VT0000167 @@ -170698,8 +271849,8 @@ synonym: "has number of of chondrocyte" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000138 ! chondrocyte -relationship: inheres_in CL:0000138 ! chondrocyte +intersection_of: RO:0000052 CL:0000138 ! inheres in chondrocyte +relationship: RO:0000052 CL:0000138 ! inheres in chondrocyte [Term] id: OBA:VT0000170 @@ -170709,8 +271860,8 @@ synonym: "functionality of blood vessel" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001981 ! blood vessel -relationship: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel +relationship: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:VT0000171 @@ -170720,8 +271871,8 @@ synonym: "functionality of blood" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:VT0000173 @@ -170731,7 +271882,7 @@ synonym: "functionality of lymphatic vessel" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000145 ! lymphatic vessel quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel [Term] id: OBA:VT0000174 @@ -170741,8 +271892,8 @@ synonym: "functionality of lymph" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002391 ! lymph -relationship: inheres_in UBERON:0002391 ! lymph +intersection_of: RO:0000052 UBERON:0002391 ! inheres in lymph +relationship: RO:0000052 UBERON:0002391 ! inheres in lymph [Term] id: OBA:VT0000180 @@ -170767,8 +271918,8 @@ synonym: "flow rate of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001574 ! flow rate intersection_of: PATO:0001574 ! flow rate -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:VT0000183 @@ -170778,8 +271929,8 @@ synonym: "pressure of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001025 ! pressure intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:VT0000184 @@ -170795,8 +271946,8 @@ def: "The amount of a triglyceride." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of triglyceride" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:17855 ! triglyceride -relationship: inheres_in CHEBI:17855 ! triglyceride +intersection_of: RO:0000052 CHEBI:17855 ! inheres in triglyceride +relationship: RO:0000052 CHEBI:17855 ! inheres in triglyceride [Term] id: OBA:VT0000188 @@ -170814,7 +271965,7 @@ synonym: "permeability of blood vessel" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000174 ! vascular permeability is_a: OBA:0003463 ! blood vessel structure intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:VT0000192 @@ -170824,8 +271975,8 @@ synonym: "amount of mineral" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:46662 ! mineral -relationship: inheres_in CHEBI:46662 ! mineral +intersection_of: RO:0000052 CHEBI:46662 ! inheres in mineral +relationship: RO:0000052 CHEBI:46662 ! inheres in mineral [Term] id: OBA:VT0000197 @@ -170834,8 +271985,8 @@ def: "The quality of a vasodilation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of vasodilation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042311 ! vasodilation -relationship: inheres_in GO:0042311 ! vasodilation +intersection_of: RO:0000052 GO:0042311 ! inheres in vasodilation +relationship: RO:0000052 GO:0042311 ! inheres in vasodilation [Term] id: OBA:VT0000198 @@ -170844,8 +271995,8 @@ def: "The quality of a vasoconstriction." [AUTO:patterns/patterns/entity_attribu synonym: "quality of vasoconstriction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042310 ! vasoconstriction -relationship: inheres_in GO:0042310 ! vasoconstriction +intersection_of: RO:0000052 GO:0042310 ! inheres in vasoconstriction +relationship: RO:0000052 GO:0042310 ! inheres in vasoconstriction [Term] id: OBA:VT0000202 @@ -170861,8 +272012,8 @@ def: "The amount of a leukocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of leukocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005333 ! hematopoietic cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000738 ! leukocyte -relationship: inheres_in CL:0000738 ! leukocyte +intersection_of: RO:0000052 CL:0000738 ! inheres in leukocyte +relationship: RO:0000052 CL:0000738 ! inheres in leukocyte [Term] id: OBA:VT0000222 @@ -170871,8 +272022,8 @@ def: "The amount of a neutrophil." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of neutrophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003294 ! granulocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000775 ! neutrophil -relationship: inheres_in CL:0000775 ! neutrophil +intersection_of: RO:0000052 CL:0000775 ! inheres in neutrophil +relationship: RO:0000052 CL:0000775 ! inheres in neutrophil [Term] id: OBA:VT0000223 @@ -170883,8 +272034,8 @@ is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000576 ! monocyte -relationship: inheres_in CL:0000576 ! monocyte +intersection_of: RO:0000052 CL:0000576 ! inheres in monocyte +relationship: RO:0000052 CL:0000576 ! inheres in monocyte [Term] id: OBA:VT0000229 @@ -170893,8 +272044,8 @@ def: "The quality of a megakaryocyte development." [AUTO:patterns/patterns/entit synonym: "quality of megakaryocyte development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001601 ! myelopoiesis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0035855 ! megakaryocyte development -relationship: inheres_in GO:0035855 ! megakaryocyte development +intersection_of: RO:0000052 GO:0035855 ! inheres in megakaryocyte development +relationship: RO:0000052 GO:0035855 ! inheres in megakaryocyte development [Term] id: OBA:VT0000237 @@ -170904,8 +272055,8 @@ synonym: "has number of of hematopoietic cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000988 ! hematopoietic cell -relationship: inheres_in CL:0000988 ! hematopoietic cell +intersection_of: RO:0000052 CL:0000988 ! inheres in hematopoietic cell +relationship: RO:0000052 CL:0000988 ! inheres in hematopoietic cell [Term] id: OBA:VT0000240 @@ -170915,7 +272066,7 @@ synonym: "position of hemopoiesis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0002123 ! hematopoiesis trait is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in GO:0030097 ! hemopoiesis +intersection_of: RO:0000052 GO:0030097 ! inheres in hemopoiesis [Term] id: OBA:VT0000245 @@ -170924,8 +272075,8 @@ def: "The quality of a erythrocyte differentiation." [AUTO:patterns/patterns/ent synonym: "quality of erythrocyte differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030218 ! erythrocyte differentiation -relationship: inheres_in GO:0030218 ! erythrocyte differentiation +intersection_of: RO:0000052 GO:0030218 ! inheres in erythrocyte differentiation +relationship: RO:0000052 GO:0030218 ! inheres in erythrocyte differentiation [Term] id: OBA:VT0000248 @@ -170935,17 +272086,17 @@ synonym: "size of erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0002447 ! erythrocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:VT0000254 name: cerebrospinal fluid amount def: "The volume of a cerebrospinal fluid." [AUTO:patterns/patterns/entity_attribute] synonym: "volume of cerebrospinal fluid" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0000036 ! body fluid levels is_a: OBA:1000166 ! cerebrospinal fluid quality -is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001359 ! cerebrospinal fluid +intersection_of: RO:0000052 UBERON:0001359 ! inheres in cerebrospinal fluid [Term] id: OBA:VT0000259 @@ -170955,7 +272106,7 @@ synonym: "permeability of capillary" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000087 ! capillary morphology trait is_a: OBA:VT0000190 ! blood vessel permeability trait intersection_of: PATO:0000970 ! permeability -intersection_of: inheres_in UBERON:0001982 ! capillary +intersection_of: RO:0000052 UBERON:0001982 ! inheres in capillary [Term] id: OBA:VT0000260 @@ -170964,8 +272115,8 @@ def: "The quality of a hemostasis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hemostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001784 ! fluid regulation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007599 ! hemostasis -relationship: inheres_in GO:0007599 ! hemostasis +intersection_of: RO:0000052 GO:0007599 ! inheres in hemostasis +relationship: RO:0000052 GO:0007599 ! inheres in hemostasis [Term] id: OBA:VT0000266 @@ -170975,8 +272126,8 @@ synonym: "morphology of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000948 ! heart -relationship: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart +relationship: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:VT0000267 @@ -170985,8 +272136,8 @@ def: "The quality of a heart development." [AUTO:patterns/patterns/entity_attrib synonym: "quality of heart development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007507 ! heart development -relationship: inheres_in GO:0007507 ! heart development +intersection_of: RO:0000052 GO:0007507 ! inheres in heart development +relationship: RO:0000052 GO:0007507 ! inheres in heart development [Term] id: OBA:VT0000268 @@ -170996,7 +272147,7 @@ synonym: "amount of strand of hair" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0000272 @@ -171005,8 +272156,8 @@ def: "The morphology of a aorta." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000947 ! aorta -relationship: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta +relationship: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:VT0000277 @@ -171016,7 +272167,7 @@ synonym: "shape of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000266 ! heart morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:VT0000285 @@ -171026,7 +272177,7 @@ synonym: "shape of cardial valve" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003469 ! cardial valve morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000946 ! cardial valve +intersection_of: RO:0000052 UBERON:0000946 ! inheres in cardial valve [Term] id: OBA:VT0000288 @@ -171036,8 +272187,8 @@ synonym: "morphology of pericardium" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002407 ! pericardium -relationship: inheres_in UBERON:0002407 ! pericardium +intersection_of: RO:0000052 UBERON:0002407 ! inheres in pericardium +relationship: RO:0000052 UBERON:0002407 ! inheres in pericardium [Term] id: OBA:VT0000315 @@ -171055,8 +272206,8 @@ synonym: "functionality of endolymph" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001852 ! endolymph -relationship: inheres_in UBERON:0001852 ! endolymph +intersection_of: RO:0000052 UBERON:0001852 ! inheres in endolymph +relationship: RO:0000052 UBERON:0001852 ! inheres in endolymph [Term] id: OBA:VT0000334 @@ -171067,8 +272218,8 @@ is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:1000866 ! blood cell quality is_a: OBA:VT0010191 ! immune system cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000094 ! granulocyte -relationship: inheres_in CL:0000094 ! granulocyte +intersection_of: RO:0000052 CL:0000094 ! inheres in granulocyte +relationship: RO:0000052 CL:0000094 ! inheres in granulocyte [Term] id: OBA:VT0000336 @@ -171078,7 +272229,7 @@ synonym: "has number of of mast cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000179 ! mast cell quality is_a: OBA:VT0010191 ! immune system cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:VT0000340 @@ -171088,7 +272239,7 @@ synonym: "functionality of perilymph" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000876 ! perilymph quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001845 ! perilymph +intersection_of: RO:0000052 UBERON:0001845 ! inheres in perilymph [Term] id: OBA:VT0000341 @@ -171098,8 +272249,8 @@ synonym: "color of bile" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001970 ! bile -relationship: inheres_in UBERON:0001970 ! bile +intersection_of: RO:0000052 UBERON:0001970 ! inheres in bile +relationship: RO:0000052 UBERON:0001970 ! inheres in bile [Term] id: OBA:VT0000344 @@ -171108,8 +272259,8 @@ def: "The morphology of a Cajal-Retzius cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of Cajal-Retzius cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000695 ! Cajal-Retzius cell -relationship: inheres_in CL:0000695 ! Cajal-Retzius cell +intersection_of: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell +relationship: RO:0000052 CL:0000695 ! inheres in Cajal-Retzius cell [Term] id: OBA:VT0000353 @@ -171119,7 +272270,7 @@ synonym: "functionality of vestibular system" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0015094 ! equilibrioception system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004681 ! vestibular system +intersection_of: RO:0000052 UBERON:0004681 ! inheres in vestibular system [Term] id: OBA:VT0000357 @@ -171129,8 +272280,8 @@ synonym: "has number of of limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002101 ! limb -relationship: inheres_in UBERON:0002101 ! limb +intersection_of: RO:0000052 UBERON:0002101 ! inheres in limb +relationship: RO:0000052 UBERON:0002101 ! inheres in limb [Term] id: OBA:VT0000359 @@ -171140,7 +272291,7 @@ synonym: "morphology of mast cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0004339 ! myeloid leukocyte morphology is_a: OBA:1000179 ! mast cell quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:VT0000367 @@ -171150,7 +272301,7 @@ synonym: "morphology of strand of hair" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000253 ! strand of hair quality is_a: OBA:VT0010007 ! skin adnexa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0000379 @@ -171160,8 +272311,8 @@ synonym: "has number of of hair follicle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002073 ! hair follicle -relationship: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle +relationship: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:VT0000383 @@ -171171,7 +272322,7 @@ synonym: "orientation of hair follicle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003482 ! hair follicle position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:VT0000384 @@ -171181,7 +272332,7 @@ synonym: "spatial pattern of hair follicle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0002076 ! hair follicle morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:VT0000385 @@ -171191,7 +272342,7 @@ synonym: "size of hair follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002076 ! hair follicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:VT0000413 @@ -171201,8 +272352,8 @@ synonym: "has number of of phalanx" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000067 ! endochondral bone quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0003221 ! phalanx -relationship: inheres_in UBERON:0003221 ! phalanx +intersection_of: RO:0000052 UBERON:0003221 ! inheres in phalanx +relationship: RO:0000052 UBERON:0003221 ! inheres in phalanx [Term] id: OBA:VT0000416 @@ -171212,7 +272363,7 @@ synonym: "mass density of strand of hair" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0000417 @@ -171223,7 +272374,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0000424 @@ -171233,7 +272384,7 @@ synonym: "growth rate of strand of hair" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0001492 ! growth rate intersection_of: PATO:0001492 ! growth rate -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0000427 @@ -171242,8 +272393,8 @@ def: "The quality of a hair cycle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hair cycle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042633 ! hair cycle -relationship: inheres_in GO:0042633 ! hair cycle +intersection_of: RO:0000052 GO:0042633 ! inheres in hair cycle +relationship: RO:0000052 GO:0042633 ! inheres in hair cycle [Term] id: OBA:VT0000430 @@ -171253,8 +272404,8 @@ synonym: "morphology of palatine process of maxilla" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005871 ! palatine process of maxilla -relationship: inheres_in UBERON:0005871 ! palatine process of maxilla +intersection_of: RO:0000052 UBERON:0005871 ! inheres in palatine process of maxilla +relationship: RO:0000052 UBERON:0005871 ! inheres in palatine process of maxilla [Term] id: OBA:VT0000431 @@ -171264,8 +272415,8 @@ synonym: "morphology of secondary palatal shelf" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005619 ! secondary palatal shelf -relationship: inheres_in UBERON:0005619 ! secondary palatal shelf +intersection_of: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf +relationship: RO:0000052 UBERON:0005619 ! inheres in secondary palatal shelf [Term] id: OBA:VT0000432 @@ -171275,7 +272426,7 @@ synonym: "morphology of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005382 ! head trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0000438 @@ -171285,7 +272436,7 @@ synonym: "morphology of skull" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000429 ! skull quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003129 ! skull +intersection_of: RO:0000052 UBERON:0003129 ! inheres in skull [Term] id: OBA:VT0000443 @@ -171295,8 +272446,8 @@ synonym: "morphology of snout" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006333 ! snout -relationship: inheres_in UBERON:0006333 ! snout +intersection_of: RO:0000052 UBERON:0006333 ! inheres in snout +relationship: RO:0000052 UBERON:0006333 ! inheres in snout [Term] id: OBA:VT0000444 @@ -171306,7 +272457,7 @@ synonym: "shape of snout" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000443 ! snout morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006333 ! snout +intersection_of: RO:0000052 UBERON:0006333 ! inheres in snout [Term] id: OBA:VT0000446 @@ -171317,7 +272468,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000443 ! snout morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006333 ! snout +intersection_of: RO:0000052 UBERON:0006333 ! inheres in snout [Term] id: OBA:VT0000449 @@ -171327,7 +272478,7 @@ synonym: "width of nasal bridge" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002088 ! nasal bridge size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0008340 ! nasal bridge +intersection_of: RO:0000052 UBERON:0008340 ! inheres in nasal bridge [Term] id: OBA:VT0000452 @@ -171337,8 +272488,8 @@ synonym: "morphology of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000165 ! mouth -relationship: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth +relationship: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:VT0000454 @@ -171348,8 +272499,8 @@ synonym: "morphology of jaw skeleton" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001708 ! jaw skeleton -relationship: inheres_in UBERON:0001708 ! jaw skeleton +intersection_of: RO:0000052 UBERON:0001708 ! inheres in jaw skeleton +relationship: RO:0000052 UBERON:0001708 ! inheres in jaw skeleton [Term] id: OBA:VT0000455 @@ -171359,8 +272510,8 @@ synonym: "morphology of maxilla" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002397 ! maxilla -relationship: inheres_in UBERON:0002397 ! maxilla +intersection_of: RO:0000052 UBERON:0002397 ! inheres in maxilla +relationship: RO:0000052 UBERON:0002397 ! inheres in maxilla [Term] id: OBA:VT0000458 @@ -171370,8 +272521,8 @@ synonym: "morphology of lower jaw region" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001710 ! lower jaw region -relationship: inheres_in UBERON:0001710 ! lower jaw region +intersection_of: RO:0000052 UBERON:0001710 ! inheres in lower jaw region +relationship: RO:0000052 UBERON:0001710 ! inheres in lower jaw region [Term] id: OBA:VT0000461 @@ -171381,7 +272532,7 @@ synonym: "has number of of trunk or cervical vertebra" EXACT [AUTO:patterns/patt is_a: OBA:1000660 ! trunk or cervical vertebra quality is_a: OBA:VT0000138 ! vertebra quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0004451 ! trunk or cervical vertebra +intersection_of: RO:0000052 UBERON:0004451 ! inheres in trunk or cervical vertebra [Term] id: OBA:VT0000462 @@ -171391,7 +272542,7 @@ synonym: "morphology of digestive system" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT1000776 ! alimentary system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001007 ! digestive system +intersection_of: RO:0000052 UBERON:0001007 ! inheres in digestive system [Term] id: OBA:VT0000467 @@ -171401,8 +272552,8 @@ synonym: "morphology of esophagus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001043 ! esophagus -relationship: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus +relationship: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:VT0000468 @@ -171412,8 +272563,8 @@ synonym: "morphology of epithelium of esophagus" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001976 ! epithelium of esophagus -relationship: inheres_in UBERON:0001976 ! epithelium of esophagus +intersection_of: RO:0000052 UBERON:0001976 ! inheres in epithelium of esophagus +relationship: RO:0000052 UBERON:0001976 ! inheres in epithelium of esophagus [Term] id: OBA:VT0000469 @@ -171422,8 +272573,8 @@ def: "The morphology of a esophagus squamous epithelium." [AUTO:patterns/pattern synonym: "morphology of esophagus squamous epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000468 ! esophageal epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006920 ! esophagus squamous epithelium -relationship: inheres_in UBERON:0006920 ! esophagus squamous epithelium +intersection_of: RO:0000052 UBERON:0006920 ! inheres in esophagus squamous epithelium +relationship: RO:0000052 UBERON:0006920 ! inheres in esophagus squamous epithelium [Term] id: OBA:VT0000470 @@ -171433,8 +272584,8 @@ synonym: "morphology of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000945 ! stomach -relationship: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach +relationship: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:VT0000471 @@ -171444,8 +272595,8 @@ synonym: "morphology of epithelium of stomach" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001276 ! epithelium of stomach -relationship: inheres_in UBERON:0001276 ! epithelium of stomach +intersection_of: RO:0000052 UBERON:0001276 ! inheres in epithelium of stomach +relationship: RO:0000052 UBERON:0001276 ! inheres in epithelium of stomach [Term] id: OBA:VT0000472 @@ -171454,8 +272605,8 @@ def: "The morphology of a stomach squamous epithelium." [AUTO:patterns/patterns/ synonym: "morphology of stomach squamous epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000471 ! stomach epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006921 ! stomach squamous epithelium -relationship: inheres_in UBERON:0006921 ! stomach squamous epithelium +intersection_of: RO:0000052 UBERON:0006921 ! inheres in stomach squamous epithelium +relationship: RO:0000052 UBERON:0006921 ! inheres in stomach squamous epithelium [Term] id: OBA:VT0000473 @@ -171464,8 +272615,8 @@ def: "The morphology of a stomach glandular epithelium." [AUTO:patterns/patterns synonym: "morphology of stomach glandular epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000471 ! stomach epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006924 ! stomach glandular epithelium -relationship: inheres_in UBERON:0006924 ! stomach glandular epithelium +intersection_of: RO:0000052 UBERON:0006924 ! inheres in stomach glandular epithelium +relationship: RO:0000052 UBERON:0006924 ! inheres in stomach glandular epithelium [Term] id: OBA:VT0000474 @@ -171475,8 +272626,8 @@ synonym: "morphology of foregut" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001041 ! foregut -relationship: inheres_in UBERON:0001041 ! foregut +intersection_of: RO:0000052 UBERON:0001041 ! inheres in foregut +relationship: RO:0000052 UBERON:0001041 ! inheres in foregut [Term] id: OBA:VT0000477 @@ -171486,8 +272637,8 @@ synonym: "morphology of intestine" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000160 ! intestine -relationship: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine +relationship: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:VT0000479 @@ -171496,8 +272647,8 @@ def: "The morphology of a enterocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of enterocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000584 ! enterocyte -relationship: inheres_in CL:0000584 ! enterocyte +intersection_of: RO:0000052 CL:0000584 ! inheres in enterocyte +relationship: RO:0000052 CL:0000584 ! inheres in enterocyte [Term] id: OBA:VT0000481 @@ -171507,8 +272658,8 @@ synonym: "has number of of enterocyte" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000584 ! enterocyte -relationship: inheres_in CL:0000584 ! enterocyte +intersection_of: RO:0000052 CL:0000584 ! inheres in enterocyte +relationship: RO:0000052 CL:0000584 ! inheres in enterocyte [Term] id: OBA:VT0000482 @@ -171518,7 +272669,7 @@ synonym: "length of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002381 ! long bone length is_a: OBA:0002384 ! fibula size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:VT0000484 @@ -171527,8 +272678,8 @@ def: "The morphology of a pulmonary artery." [AUTO:patterns/patterns/entity_attr synonym: "morphology of pulmonary artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002012 ! pulmonary artery -relationship: inheres_in UBERON:0002012 ! pulmonary artery +intersection_of: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery +relationship: RO:0000052 UBERON:0002012 ! inheres in pulmonary artery [Term] id: OBA:VT0000488 @@ -171538,8 +272689,8 @@ synonym: "morphology of intestinal epithelium" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001277 ! intestinal epithelium -relationship: inheres_in UBERON:0001277 ! intestinal epithelium +intersection_of: RO:0000052 UBERON:0001277 ! inheres in intestinal epithelium +relationship: RO:0000052 UBERON:0001277 ! inheres in intestinal epithelium [Term] id: OBA:VT0000489 @@ -171549,8 +272700,8 @@ synonym: "morphology of large intestine" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000059 ! large intestine -relationship: inheres_in UBERON:0000059 ! large intestine +intersection_of: RO:0000052 UBERON:0000059 ! inheres in large intestine +relationship: RO:0000052 UBERON:0000059 ! inheres in large intestine [Term] id: OBA:VT0000490 @@ -171559,8 +272710,8 @@ def: "The morphology of a crypt of Lieberkuhn." [AUTO:patterns/patterns/entity_a synonym: "morphology of crypt of Lieberkuhn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002163 ! gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001983 ! crypt of Lieberkuhn -relationship: inheres_in UBERON:0001983 ! crypt of Lieberkuhn +intersection_of: RO:0000052 UBERON:0001983 ! inheres in crypt of Lieberkuhn +relationship: RO:0000052 UBERON:0001983 ! inheres in crypt of Lieberkuhn [Term] id: OBA:VT0000492 @@ -171570,8 +272721,8 @@ synonym: "morphology of rectum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001052 ! rectum -relationship: inheres_in UBERON:0001052 ! rectum +intersection_of: RO:0000052 UBERON:0001052 ! inheres in rectum +relationship: RO:0000052 UBERON:0001052 ! inheres in rectum [Term] id: OBA:VT0000494 @@ -171581,8 +272732,8 @@ synonym: "morphology of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001153 ! caecum -relationship: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum +relationship: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:VT0000495 @@ -171592,8 +272743,8 @@ synonym: "morphology of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001155 ! colon -relationship: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon +relationship: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:VT0000496 @@ -171603,8 +272754,8 @@ synonym: "morphology of small intestine" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002108 ! small intestine -relationship: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine +relationship: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:VT0000497 @@ -171613,8 +272764,8 @@ def: "The position of a small intestine." [AUTO:patterns/patterns/entity_attribu synonym: "position of small intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002108 ! small intestine -relationship: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine +relationship: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:VT0000511 @@ -171624,8 +272775,8 @@ synonym: "morphology of intestinal mucosa" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001242 ! intestinal mucosa -relationship: inheres_in UBERON:0001242 ! intestinal mucosa +intersection_of: RO:0000052 UBERON:0001242 ! inheres in intestinal mucosa +relationship: RO:0000052 UBERON:0001242 ! inheres in intestinal mucosa [Term] id: OBA:VT0000516 @@ -171635,7 +272786,7 @@ synonym: "morphology of renal system" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT1000777 ! urinary system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001008 ! renal system +intersection_of: RO:0000052 UBERON:0001008 ! inheres in renal system [Term] id: OBA:VT0000521 @@ -171645,7 +272796,7 @@ synonym: "morphology of cortex of kidney" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000169 ! cortex of kidney quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001225 ! cortex of kidney +intersection_of: RO:0000052 UBERON:0001225 ! inheres in cortex of kidney [Term] id: OBA:VT0000524 @@ -171655,8 +272806,8 @@ synonym: "has number of of nephron tubule" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001231 ! nephron tubule -relationship: inheres_in UBERON:0001231 ! nephron tubule +intersection_of: RO:0000052 UBERON:0001231 ! inheres in nephron tubule +relationship: RO:0000052 UBERON:0001231 ! inheres in nephron tubule [Term] id: OBA:VT0000526 @@ -171666,7 +272817,7 @@ synonym: "size of kidney pyramid" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004192 ! kidney pyramid morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004200 ! kidney pyramid +intersection_of: RO:0000052 UBERON:0004200 ! inheres in kidney pyramid [Term] id: OBA:VT0000527 @@ -171675,8 +272826,8 @@ def: "The quality of a kidney development." [AUTO:patterns/patterns/entity_attri synonym: "quality of kidney development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001822 ! kidney development -relationship: inheres_in GO:0001822 ! kidney development +intersection_of: RO:0000052 GO:0001822 ! inheres in kidney development +relationship: RO:0000052 GO:0001822 ! inheres in kidney development [Term] id: OBA:VT0000530 @@ -171686,7 +272837,7 @@ synonym: "morphology of kidney blood vessel" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000818 ! kidney blood vessel quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003517 ! kidney blood vessel +intersection_of: RO:0000052 UBERON:0003517 ! inheres in kidney blood vessel [Term] id: OBA:VT0000534 @@ -171696,8 +272847,8 @@ synonym: "morphology of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000056 ! ureter -relationship: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter +relationship: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0000537 @@ -171707,8 +272858,8 @@ synonym: "morphology of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000057 ! urethra -relationship: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra +relationship: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:VT0000538 @@ -171718,8 +272869,8 @@ synonym: "morphology of urinary bladder" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001255 ! urinary bladder -relationship: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder +relationship: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:VT0000539 @@ -171729,7 +272880,7 @@ synonym: "size of urinary bladder" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000538 ! urinary bladder morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:VT0000541 @@ -171738,8 +272889,8 @@ def: "The morphology of a urinary bladder urothelium." [AUTO:patterns/patterns/e synonym: "morphology of urinary bladder urothelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003630 ! urothelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004645 ! urinary bladder urothelium -relationship: inheres_in UBERON:0004645 ! urinary bladder urothelium +intersection_of: RO:0000052 UBERON:0004645 ! inheres in urinary bladder urothelium +relationship: RO:0000052 UBERON:0004645 ! inheres in urinary bladder urothelium [Term] id: OBA:VT0000544 @@ -171749,7 +272900,7 @@ synonym: "thickness of urinary bladder urothelium" EXACT [AUTO:patterns/patterns is_a: OBA:0003517 ! urinary bladder urothelium size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0004645 ! urinary bladder urothelium +intersection_of: RO:0000052 UBERON:0004645 ! inheres in urinary bladder urothelium [Term] id: OBA:VT0000548 @@ -171760,7 +272911,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002109 ! limb morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002101 ! limb +intersection_of: RO:0000052 UBERON:0002101 ! inheres in limb [Term] id: OBA:VT0000550 @@ -171769,8 +272920,8 @@ def: "The morphology of a forelimb." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of forelimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002109 ! limb morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002102 ! forelimb -relationship: inheres_in UBERON:0002102 ! forelimb +intersection_of: RO:0000052 UBERON:0002102 ! inheres in forelimb +relationship: RO:0000052 UBERON:0002102 ! inheres in forelimb [Term] id: OBA:VT0000552 @@ -171781,7 +272932,7 @@ is_a: OBA:0002478 ! forelimb zeugopod bone morphology is_a: OBA:1000591 ! radius bone quality is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:VT0000554 @@ -171791,8 +272942,8 @@ synonym: "morphology of carpal region" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004452 ! carpal region -relationship: inheres_in UBERON:0004452 ! carpal region +intersection_of: RO:0000052 UBERON:0004452 ! inheres in carpal region +relationship: RO:0000052 UBERON:0004452 ! inheres in carpal region [Term] id: OBA:VT0000556 @@ -171801,8 +272952,8 @@ def: "The morphology of a hindlimb." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hindlimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002109 ! limb morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002103 ! hindlimb -relationship: inheres_in UBERON:0002103 ! hindlimb +intersection_of: RO:0000052 UBERON:0002103 ! inheres in hindlimb +relationship: RO:0000052 UBERON:0002103 ! inheres in hindlimb [Term] id: OBA:VT0000558 @@ -171812,7 +272963,7 @@ synonym: "morphology of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000340 ! tibia quality is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT0000559 @@ -171822,7 +272973,7 @@ synonym: "morphology of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000621 ! femur quality is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0000572 @@ -171832,8 +272983,8 @@ synonym: "morphology of autopod region" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002470 ! autopod region -relationship: inheres_in UBERON:0002470 ! autopod region +intersection_of: RO:0000052 UBERON:0002470 ! inheres in autopod region +relationship: RO:0000052 UBERON:0002470 ! inheres in autopod region [Term] id: OBA:VT0000573 @@ -171843,8 +272994,8 @@ synonym: "size of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000572 ! autopod morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002387 ! pes -relationship: inheres_in UBERON:0002387 ! pes +intersection_of: RO:0000052 UBERON:0002387 ! inheres in pes +relationship: RO:0000052 UBERON:0002387 ! inheres in pes [Term] id: OBA:VT0000574 @@ -171853,8 +273004,8 @@ def: "The morphology of a metapodial pad." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of metapodial pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008838 ! metapodial pad -relationship: inheres_in UBERON:0008838 ! metapodial pad +intersection_of: RO:0000052 UBERON:0008838 ! inheres in metapodial pad +relationship: RO:0000052 UBERON:0008838 ! inheres in metapodial pad [Term] id: OBA:VT0000579 @@ -171863,8 +273014,8 @@ def: "The morphology of a nail." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005148 ! integumentary adnexa morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001705 ! nail -relationship: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail +relationship: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:VT0000580 @@ -171874,7 +273025,7 @@ synonym: "shape of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000579 ! nail morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:VT0000583 @@ -171884,7 +273035,7 @@ synonym: "length of nail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002254 ! nail size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001705 ! nail +intersection_of: RO:0000052 UBERON:0001705 ! inheres in nail [Term] id: OBA:VT0000588 @@ -171894,7 +273045,7 @@ synonym: "diameter of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003456 ! tail size trait is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:VT0000596 @@ -171903,8 +273054,8 @@ def: "The quality of a liver development." [AUTO:patterns/patterns/entity_attrib synonym: "quality of liver development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001889 ! liver development -relationship: inheres_in GO:0001889 ! liver development +intersection_of: RO:0000052 GO:0001889 ! inheres in liver development +relationship: RO:0000052 GO:0001889 ! inheres in liver development [Term] id: OBA:VT0000598 @@ -171915,7 +273066,7 @@ is_a: OBA:0005862 ! exocrine gland morphology is_a: OBA:0005864 ! endocrine gland morphology is_a: OBA:1000635 ! liver quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:VT0000599 @@ -171925,7 +273076,7 @@ synonym: "size of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000598 ! liver morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:VT0000602 @@ -171935,8 +273086,8 @@ synonym: "size of sinusoidal space" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0014399 ! sinusoidal space -relationship: inheres_in UBERON:0014399 ! sinusoidal space +intersection_of: RO:0000052 UBERON:0014399 ! inheres in sinusoidal space +relationship: RO:0000052 UBERON:0014399 ! inheres in sinusoidal space [Term] id: OBA:VT0000603 @@ -171946,7 +273097,7 @@ synonym: "color of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000598 ! liver morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:VT0000606 @@ -171956,8 +273107,8 @@ synonym: "has number of of hepatocyte" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000182 ! hepatocyte -relationship: inheres_in CL:0000182 ! hepatocyte +intersection_of: RO:0000052 CL:0000182 ! inheres in hepatocyte +relationship: RO:0000052 CL:0000182 ! inheres in hepatocyte [Term] id: OBA:VT0000607 @@ -171966,8 +273117,8 @@ def: "The morphology of a hepatocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hepatocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000182 ! hepatocyte -relationship: inheres_in CL:0000182 ! hepatocyte +intersection_of: RO:0000052 CL:0000182 ! inheres in hepatocyte +relationship: RO:0000052 CL:0000182 ! inheres in hepatocyte [Term] id: OBA:VT0000609 @@ -171978,7 +273129,7 @@ is_a: OBA:0005863 ! exocrine gland functionality is_a: OBA:0005865 ! endocrine gland functionality is_a: OBA:1000635 ! liver quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:VT0000613 @@ -171987,8 +273138,8 @@ def: "The morphology of a saliva-secreting gland." [AUTO:patterns/patterns/entit synonym: "morphology of saliva-secreting gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001044 ! saliva-secreting gland -relationship: inheres_in UBERON:0001044 ! saliva-secreting gland +intersection_of: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland +relationship: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland [Term] id: OBA:VT0000615 @@ -171998,8 +273149,8 @@ synonym: "morphology of palatine gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0003791 ! minor salivary gland morphology trait is_a: OBA:VT4000012 ! mucous gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002447 ! palatine gland -relationship: inheres_in UBERON:0002447 ! palatine gland +intersection_of: RO:0000052 UBERON:0002447 ! inheres in palatine gland +relationship: RO:0000052 UBERON:0002447 ! inheres in palatine gland [Term] id: OBA:VT0000620 @@ -172009,8 +273160,8 @@ synonym: "morphology of duct of salivary gland" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001837 ! duct of salivary gland -relationship: inheres_in UBERON:0001837 ! duct of salivary gland +intersection_of: RO:0000052 UBERON:0001837 ! inheres in duct of salivary gland +relationship: RO:0000052 UBERON:0001837 ! inheres in duct of salivary gland [Term] id: OBA:VT0000623 @@ -172019,8 +273170,8 @@ def: "The quality of a saliva secretion." [AUTO:patterns/patterns/entity_attribu synonym: "quality of saliva secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001784 ! fluid regulation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0046541 ! saliva secretion -relationship: inheres_in GO:0046541 ! saliva secretion +intersection_of: RO:0000052 GO:0046541 ! inheres in saliva secretion +relationship: RO:0000052 GO:0046541 ! inheres in saliva secretion [Term] id: OBA:VT0000627 @@ -172029,8 +273180,8 @@ def: "The morphology of a mammary gland." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0000628 @@ -172039,8 +273190,8 @@ def: "The quality of a mammary gland development." [AUTO:patterns/patterns/entit synonym: "quality of mammary gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030879 ! mammary gland development -relationship: inheres_in GO:0030879 ! mammary gland development +intersection_of: RO:0000052 GO:0030879 ! inheres in mammary gland development +relationship: RO:0000052 GO:0030879 ! inheres in mammary gland development [Term] id: OBA:VT0000631 @@ -172049,8 +273200,8 @@ def: "The morphology of a neuroendocrine gland." [AUTO:patterns/patterns/entity_ synonym: "morphology of neuroendocrine gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010133 ! neuroendocrine gland -relationship: inheres_in UBERON:0010133 ! neuroendocrine gland +intersection_of: RO:0000052 UBERON:0010133 ! inheres in neuroendocrine gland +relationship: RO:0000052 UBERON:0010133 ! inheres in neuroendocrine gland [Term] id: OBA:VT0000632 @@ -172059,8 +273210,8 @@ def: "The morphology of a pineal body." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of pineal body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005867 ! secretory circumventricular organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001905 ! pineal body -relationship: inheres_in UBERON:0001905 ! pineal body +intersection_of: RO:0000052 UBERON:0001905 ! inheres in pineal body +relationship: RO:0000052 UBERON:0001905 ! inheres in pineal body [Term] id: OBA:VT0000633 @@ -172070,7 +273221,7 @@ synonym: "morphology of pituitary gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000518 ! pituitary gland quality is_a: OBA:VT0000631 ! neuroendocrine gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:VT0000639 @@ -172079,8 +273230,8 @@ def: "The morphology of a adrenal gland." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002369 ! adrenal gland -relationship: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland +relationship: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:VT0000643 @@ -172090,8 +273241,8 @@ synonym: "morphology of adrenal medulla" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001236 ! adrenal medulla -relationship: inheres_in UBERON:0001236 ! adrenal medulla +intersection_of: RO:0000052 UBERON:0001236 ! inheres in adrenal medulla +relationship: RO:0000052 UBERON:0001236 ! inheres in adrenal medulla [Term] id: OBA:VT0000646 @@ -172100,8 +273251,8 @@ def: "The morphology of a cortical cell of adrenal gland." [AUTO:patterns/patter synonym: "morphology of cortical cell of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002097 ! cortical cell of adrenal gland -relationship: inheres_in CL:0002097 ! cortical cell of adrenal gland +intersection_of: RO:0000052 CL:0002097 ! inheres in cortical cell of adrenal gland +relationship: RO:0000052 CL:0002097 ! inheres in cortical cell of adrenal gland [Term] id: OBA:VT0000647 @@ -172111,8 +273262,8 @@ synonym: "morphology of sebaceous gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005148 ! integumentary adnexa morphology is_a: OBA:0005855 ! holocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001821 ! sebaceous gland -relationship: inheres_in UBERON:0001821 ! sebaceous gland +intersection_of: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland +relationship: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland [Term] id: OBA:VT0000652 @@ -172122,7 +273273,7 @@ synonym: "size of sebaceous gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000647 ! sebaceous gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001821 ! sebaceous gland +intersection_of: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland [Term] id: OBA:VT0000653 @@ -172131,8 +273282,8 @@ def: "The morphology of a reproductive gland." [AUTO:patterns/patterns/entity_at synonym: "morphology of reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002163 ! gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003937 ! reproductive gland -relationship: inheres_in UBERON:0003937 ! reproductive gland +intersection_of: RO:0000052 UBERON:0003937 ! inheres in reproductive gland +relationship: RO:0000052 UBERON:0003937 ! inheres in reproductive gland [Term] id: OBA:VT0000655 @@ -172142,7 +273293,7 @@ synonym: "size of reproductive gland" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000653 ! sex gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003937 ! reproductive gland +intersection_of: RO:0000052 UBERON:0003937 ! inheres in reproductive gland [Term] id: OBA:VT0000659 @@ -172152,7 +273303,7 @@ synonym: "size of prostate gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0001158 ! prostate morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002367 ! prostate gland +intersection_of: RO:0000052 UBERON:0002367 ! inheres in prostate gland [Term] id: OBA:VT0000660 @@ -172161,8 +273312,8 @@ def: "The size of a prostate gland lateral lobe." [AUTO:patterns/patterns/entity synonym: "size of prostate gland lateral lobe" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013637 ! prostate gland lateral lobe -relationship: inheres_in UBERON:0013637 ! prostate gland lateral lobe +intersection_of: RO:0000052 UBERON:0013637 ! inheres in prostate gland lateral lobe +relationship: RO:0000052 UBERON:0013637 ! inheres in prostate gland lateral lobe [Term] id: OBA:VT0000661 @@ -172172,7 +273323,7 @@ synonym: "size of prostate gland ventral lobe" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004708 ! prostate gland ventral lobe morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0007615 ! prostate gland ventral lobe +intersection_of: RO:0000052 UBERON:0007615 ! inheres in prostate gland ventral lobe [Term] id: OBA:VT0000666 @@ -172182,8 +273333,8 @@ synonym: "amount of prostate duct" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002485 ! prostate duct -relationship: inheres_in UBERON:0002485 ! prostate duct +intersection_of: RO:0000052 UBERON:0002485 ! inheres in prostate duct +relationship: RO:0000052 UBERON:0002485 ! inheres in prostate duct [Term] id: OBA:VT0000674 @@ -172193,8 +273344,8 @@ synonym: "morphology of sweat gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0005148 ! integumentary adnexa morphology is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001820 ! sweat gland -relationship: inheres_in UBERON:0001820 ! sweat gland +intersection_of: RO:0000052 UBERON:0001820 ! inheres in sweat gland +relationship: RO:0000052 UBERON:0001820 ! inheres in sweat gland [Term] id: OBA:VT0000678 @@ -172203,8 +273354,8 @@ def: "The morphology of a parathyroid gland." [AUTO:patterns/patterns/entity_att synonym: "morphology of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland -relationship: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland +relationship: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:VT0000681 @@ -172213,8 +273364,8 @@ def: "The morphology of a thyroid gland." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002046 ! thyroid gland -relationship: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland +relationship: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:VT0000685 @@ -172224,7 +273375,7 @@ synonym: "morphology of immune system" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT1000783 ! immune system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002405 ! immune system +intersection_of: RO:0000052 UBERON:0002405 ! inheres in immune system [Term] id: OBA:VT0000689 @@ -172234,7 +273385,7 @@ synonym: "structure of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003537 ! spleen morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:VT0000696 @@ -172243,8 +273394,8 @@ def: "The morphology of a Peyer's patch." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of Peyer's patch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002378 ! gut-associated lymphoid tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001211 ! Peyer's patch -relationship: inheres_in UBERON:0001211 ! Peyer's patch +intersection_of: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch +relationship: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch [Term] id: OBA:VT0000700 @@ -172254,8 +273405,8 @@ synonym: "has number of of lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0000029 ! lymph node -relationship: inheres_in UBERON:0000029 ! lymph node +intersection_of: RO:0000052 UBERON:0000029 ! inheres in lymph node +relationship: RO:0000052 UBERON:0000029 ! inheres in lymph node [Term] id: OBA:VT0000701 @@ -172265,7 +273416,7 @@ synonym: "size of lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003703 ! lymph node morphology is_a: OBA:VT0002221 ! immune system organ size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000029 ! lymph node +intersection_of: RO:0000052 UBERON:0000029 ! inheres in lymph node [Term] id: OBA:VT0000703 @@ -172275,7 +273426,7 @@ synonym: "structure of thymus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003539 ! thymus morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:VT0000704 @@ -172284,8 +273435,8 @@ def: "The quality of a thymus development." [AUTO:patterns/patterns/entity_attri synonym: "quality of thymus development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048538 ! thymus development -relationship: inheres_in GO:0048538 ! thymus development +intersection_of: RO:0000052 GO:0048538 ! inheres in thymus development +relationship: RO:0000052 GO:0048538 ! inheres in thymus development [Term] id: OBA:VT0000712 @@ -172294,8 +273445,8 @@ def: "The quality of a vestibular receptor cell development." [AUTO:patterns/pat synonym: "quality of vestibular receptor cell development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060118 ! vestibular receptor cell development -relationship: inheres_in GO:0060118 ! vestibular receptor cell development +intersection_of: RO:0000052 GO:0060118 ! inheres in vestibular receptor cell development +relationship: RO:0000052 GO:0060118 ! inheres in vestibular receptor cell development [Term] id: OBA:VT0000715 @@ -172304,8 +273455,8 @@ def: "The has number of of a thymocyte." [AUTO:patterns/patterns/entity_attribut synonym: "has number of of thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000893 ! thymocyte -relationship: inheres_in CL:0000893 ! thymocyte +intersection_of: RO:0000052 CL:0000893 ! inheres in thymocyte +relationship: RO:0000052 CL:0000893 ! inheres in thymocyte [Term] id: OBA:VT0000716 @@ -172321,8 +273472,8 @@ def: "The has number of of a lymphocyte." [AUTO:patterns/patterns/entity_attribu synonym: "has number of of lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010191 ! immune system cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000542 ! lymphocyte -relationship: inheres_in CL:0000542 ! lymphocyte +intersection_of: RO:0000052 CL:0000542 ! inheres in lymphocyte +relationship: RO:0000052 CL:0000542 ! inheres in lymphocyte [Term] id: OBA:VT0000737 @@ -172331,8 +273482,8 @@ def: "The quality of a myotome development." [AUTO:patterns/patterns/entity_attr synonym: "quality of myotome development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061055 ! myotome development -relationship: inheres_in GO:0061055 ! myotome development +intersection_of: RO:0000052 GO:0061055 ! inheres in myotome development +relationship: RO:0000052 GO:0061055 ! inheres in myotome development [Term] id: OBA:VT0000740 @@ -172342,8 +273493,8 @@ synonym: "contractility of smooth muscle tissue" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0001135 ! smooth muscle tissue -relationship: inheres_in UBERON:0001135 ! smooth muscle tissue +intersection_of: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue +relationship: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue [Term] id: OBA:VT0000741 @@ -172352,8 +273503,8 @@ def: "The contractility of a urinary bladder detrusor smooth muscle." [AUTO:patt synonym: "contractility of urinary bladder detrusor smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000740 ! smooth muscle contractility trait intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0000381 ! urinary bladder detrusor smooth muscle -relationship: inheres_in UBERON:0000381 ! urinary bladder detrusor smooth muscle +intersection_of: RO:0000052 UBERON:0000381 ! inheres in urinary bladder detrusor smooth muscle +relationship: RO:0000052 UBERON:0000381 ! inheres in urinary bladder detrusor smooth muscle [Term] id: OBA:VT0000742 @@ -172363,8 +273514,8 @@ synonym: "contractility of muscle layer of ileum" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0014390 ! muscle layer of ileum -relationship: inheres_in UBERON:0014390 ! muscle layer of ileum +intersection_of: RO:0000052 UBERON:0014390 ! inheres in muscle layer of ileum +relationship: RO:0000052 UBERON:0014390 ! inheres in muscle layer of ileum [Term] id: OBA:VT0000759 @@ -172374,8 +273525,8 @@ synonym: "morphology of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue -relationship: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue +relationship: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:VT0000761 @@ -172385,7 +273536,7 @@ synonym: "thickness of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0010115 ! diaphragm size trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:VT0000762 @@ -172395,8 +273546,8 @@ synonym: "morphology of tongue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001723 ! tongue -relationship: inheres_in UBERON:0001723 ! tongue +intersection_of: RO:0000052 UBERON:0001723 ! inheres in tongue +relationship: RO:0000052 UBERON:0001723 ! inheres in tongue [Term] id: OBA:VT0000763 @@ -172406,7 +273557,7 @@ synonym: "morphology of filiform papilla" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000921 ! filiform papilla quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002467 ! filiform papilla +intersection_of: RO:0000052 UBERON:0002467 ! inheres in filiform papilla [Term] id: OBA:VT0000764 @@ -172416,8 +273567,8 @@ synonym: "morphology of epithelium of tongue" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003357 ! epithelium of tongue -relationship: inheres_in UBERON:0003357 ! epithelium of tongue +intersection_of: RO:0000052 UBERON:0003357 ! inheres in epithelium of tongue +relationship: RO:0000052 UBERON:0003357 ! inheres in epithelium of tongue [Term] id: OBA:VT0000765 @@ -172426,8 +273577,8 @@ def: "The morphology of a tongue squamous epithelium." [AUTO:patterns/patterns/e synonym: "morphology of tongue squamous epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000764 ! tongue epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006919 ! tongue squamous epithelium -relationship: inheres_in UBERON:0006919 ! tongue squamous epithelium +intersection_of: RO:0000052 UBERON:0006919 ! inheres in tongue squamous epithelium +relationship: RO:0000052 UBERON:0006919 ! inheres in tongue squamous epithelium [Term] id: OBA:VT0000767 @@ -172437,8 +273588,8 @@ synonym: "morphology of smooth muscle tissue" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001135 ! smooth muscle tissue -relationship: inheres_in UBERON:0001135 ! smooth muscle tissue +intersection_of: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue +relationship: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue [Term] id: OBA:VT0000768 @@ -172448,8 +273599,8 @@ synonym: "morphology of common crus of semicircular duct" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013764 ! common crus of semicircular duct -relationship: inheres_in UBERON:0013764 ! common crus of semicircular duct +intersection_of: RO:0000052 UBERON:0013764 ! inheres in common crus of semicircular duct +relationship: RO:0000052 UBERON:0013764 ! inheres in common crus of semicircular duct [Term] id: OBA:VT0000771 @@ -172459,7 +273610,7 @@ synonym: "size of brain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002152 ! brain morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000955 ! brain +intersection_of: RO:0000052 UBERON:0000955 ! inheres in brain [Term] id: OBA:VT0000776 @@ -172469,7 +273620,7 @@ synonym: "morphology of inferior colliculus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000897 ! inferior colliculus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001946 ! inferior colliculus +intersection_of: RO:0000052 UBERON:0001946 ! inheres in inferior colliculus [Term] id: OBA:VT0000777 @@ -172479,7 +273630,7 @@ synonym: "size of inferior colliculus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000776 ! inferior colliculus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001946 ! inferior colliculus +intersection_of: RO:0000052 UBERON:0001946 ! inheres in inferior colliculus [Term] id: OBA:VT0000778 @@ -172489,8 +273640,8 @@ synonym: "morphology of axon tract" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001018 ! axon tract -relationship: inheres_in UBERON:0001018 ! axon tract +intersection_of: RO:0000052 UBERON:0001018 ! inheres in axon tract +relationship: RO:0000052 UBERON:0001018 ! inheres in axon tract [Term] id: OBA:VT0000779 @@ -172500,8 +273651,8 @@ synonym: "morphology of cochlear basement membrane" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011922 ! cochlear basement membrane -relationship: inheres_in UBERON:0011922 ! cochlear basement membrane +intersection_of: RO:0000052 UBERON:0011922 ! inheres in cochlear basement membrane +relationship: RO:0000052 UBERON:0011922 ! inheres in cochlear basement membrane [Term] id: OBA:VT0000780 @@ -172510,8 +273661,8 @@ def: "The morphology of a corpus callosum." [AUTO:patterns/patterns/entity_attri synonym: "morphology of corpus callosum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004326 ! dorsal telencephalic commissure morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002336 ! corpus callosum -relationship: inheres_in UBERON:0002336 ! corpus callosum +intersection_of: RO:0000052 UBERON:0002336 ! inheres in corpus callosum +relationship: RO:0000052 UBERON:0002336 ! inheres in corpus callosum [Term] id: OBA:VT0000781 @@ -172521,7 +273672,7 @@ synonym: "size of corpus callosum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000780 ! corpus callosum morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002336 ! corpus callosum +intersection_of: RO:0000052 UBERON:0002336 ! inheres in corpus callosum [Term] id: OBA:VT0000783 @@ -172531,8 +273682,8 @@ synonym: "morphology of forebrain" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001890 ! forebrain -relationship: inheres_in UBERON:0001890 ! forebrain +intersection_of: RO:0000052 UBERON:0001890 ! inheres in forebrain +relationship: RO:0000052 UBERON:0001890 ! inheres in forebrain [Term] id: OBA:VT0000787 @@ -172542,8 +273693,8 @@ synonym: "morphology of future telencephalon" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014371 ! future telencephalon -relationship: inheres_in UBERON:0014371 ! future telencephalon +intersection_of: RO:0000052 UBERON:0014371 ! inheres in future telencephalon +relationship: RO:0000052 UBERON:0014371 ! inheres in future telencephalon [Term] id: OBA:VT0000788 @@ -172553,8 +273704,8 @@ synonym: "morphology of cerebral cortex" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000956 ! cerebral cortex -relationship: inheres_in UBERON:0000956 ! cerebral cortex +intersection_of: RO:0000052 UBERON:0000956 ! inheres in cerebral cortex +relationship: RO:0000052 UBERON:0000956 ! inheres in cerebral cortex [Term] id: OBA:VT0000789 @@ -172565,7 +273716,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0015106 ! neocortex morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001950 ! neocortex +intersection_of: RO:0000052 UBERON:0001950 ! inheres in neocortex [Term] id: OBA:VT0000791 @@ -172575,8 +273726,8 @@ synonym: "morphology of layer of neocortex" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002301 ! layer of neocortex -relationship: inheres_in UBERON:0002301 ! layer of neocortex +intersection_of: RO:0000052 UBERON:0002301 ! inheres in layer of neocortex +relationship: RO:0000052 UBERON:0002301 ! inheres in layer of neocortex [Term] id: OBA:VT0000792 @@ -172586,8 +273737,8 @@ synonym: "morphology of brain marginal zone" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010403 ! brain marginal zone -relationship: inheres_in UBERON:0010403 ! brain marginal zone +intersection_of: RO:0000052 UBERON:0010403 ! inheres in brain marginal zone +relationship: RO:0000052 UBERON:0010403 ! inheres in brain marginal zone [Term] id: OBA:VT0000794 @@ -172597,8 +273748,8 @@ synonym: "morphology of parietal lobe" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001872 ! parietal lobe -relationship: inheres_in UBERON:0001872 ! parietal lobe +intersection_of: RO:0000052 UBERON:0001872 ! inheres in parietal lobe +relationship: RO:0000052 UBERON:0001872 ! inheres in parietal lobe [Term] id: OBA:VT0000795 @@ -172608,8 +273759,8 @@ synonym: "morphology of postcentral gyrus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002581 ! postcentral gyrus -relationship: inheres_in UBERON:0002581 ! postcentral gyrus +intersection_of: RO:0000052 UBERON:0002581 ! inheres in postcentral gyrus +relationship: RO:0000052 UBERON:0002581 ! inheres in postcentral gyrus [Term] id: OBA:VT0000796 @@ -172619,8 +273770,8 @@ synonym: "morphology of sensory dissociation area" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003938 ! sensory dissociation area -relationship: inheres_in UBERON:0003938 ! sensory dissociation area +intersection_of: RO:0000052 UBERON:0003938 ! inheres in sensory dissociation area +relationship: RO:0000052 UBERON:0003938 ! inheres in sensory dissociation area [Term] id: OBA:VT0000797 @@ -172630,8 +273781,8 @@ synonym: "morphology of supramarginal gyrus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002688 ! supramarginal gyrus -relationship: inheres_in UBERON:0002688 ! supramarginal gyrus +intersection_of: RO:0000052 UBERON:0002688 ! inheres in supramarginal gyrus +relationship: RO:0000052 UBERON:0002688 ! inheres in supramarginal gyrus [Term] id: OBA:VT0000798 @@ -172641,8 +273792,8 @@ synonym: "morphology of frontal cortex" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001870 ! frontal cortex -relationship: inheres_in UBERON:0001870 ! frontal cortex +intersection_of: RO:0000052 UBERON:0001870 ! inheres in frontal cortex +relationship: RO:0000052 UBERON:0001870 ! inheres in frontal cortex [Term] id: OBA:VT0000799 @@ -172652,8 +273803,8 @@ synonym: "morphology of precentral gyrus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002703 ! precentral gyrus -relationship: inheres_in UBERON:0002703 ! precentral gyrus +intersection_of: RO:0000052 UBERON:0002703 ! inheres in precentral gyrus +relationship: RO:0000052 UBERON:0002703 ! inheres in precentral gyrus [Term] id: OBA:VT0000800 @@ -172663,8 +273814,8 @@ synonym: "morphology of primary motor cortex" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001384 ! primary motor cortex -relationship: inheres_in UBERON:0001384 ! primary motor cortex +intersection_of: RO:0000052 UBERON:0001384 ! inheres in primary motor cortex +relationship: RO:0000052 UBERON:0001384 ! inheres in primary motor cortex [Term] id: OBA:VT0000801 @@ -172674,8 +273825,8 @@ synonym: "morphology of temporal lobe" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001871 ! temporal lobe -relationship: inheres_in UBERON:0001871 ! temporal lobe +intersection_of: RO:0000052 UBERON:0001871 ! inheres in temporal lobe +relationship: RO:0000052 UBERON:0001871 ! inheres in temporal lobe [Term] id: OBA:VT0000802 @@ -172685,8 +273836,8 @@ synonym: "morphology of superior temporal gyrus" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002769 ! superior temporal gyrus -relationship: inheres_in UBERON:0002769 ! superior temporal gyrus +intersection_of: RO:0000052 UBERON:0002769 ! inheres in superior temporal gyrus +relationship: RO:0000052 UBERON:0002769 ! inheres in superior temporal gyrus [Term] id: OBA:VT0000803 @@ -172696,8 +273847,8 @@ synonym: "morphology of transverse gyrus of Heschl" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003939 ! transverse gyrus of Heschl -relationship: inheres_in UBERON:0003939 ! transverse gyrus of Heschl +intersection_of: RO:0000052 UBERON:0003939 ! inheres in transverse gyrus of Heschl +relationship: RO:0000052 UBERON:0003939 ! inheres in transverse gyrus of Heschl [Term] id: OBA:VT0000804 @@ -172707,8 +273858,8 @@ synonym: "morphology of occipital lobe" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002021 ! occipital lobe -relationship: inheres_in UBERON:0002021 ! occipital lobe +intersection_of: RO:0000052 UBERON:0002021 ! inheres in occipital lobe +relationship: RO:0000052 UBERON:0002021 ! inheres in occipital lobe [Term] id: OBA:VT0000805 @@ -172718,8 +273869,8 @@ synonym: "morphology of primary visual cortex" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002436 ! primary visual cortex -relationship: inheres_in UBERON:0002436 ! primary visual cortex +intersection_of: RO:0000052 UBERON:0002436 ! inheres in primary visual cortex +relationship: RO:0000052 UBERON:0002436 ! inheres in primary visual cortex [Term] id: OBA:VT0000807 @@ -172729,8 +273880,8 @@ synonym: "morphology of hippocampal formation" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002421 ! hippocampal formation -relationship: inheres_in UBERON:0002421 ! hippocampal formation +intersection_of: RO:0000052 UBERON:0002421 ! inheres in hippocampal formation +relationship: RO:0000052 UBERON:0002421 ! inheres in hippocampal formation [Term] id: OBA:VT0000808 @@ -172739,8 +273890,8 @@ def: "The quality of a hippocampus development." [AUTO:patterns/patterns/entity_ synonym: "quality of hippocampus development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021766 ! hippocampus development -relationship: inheres_in GO:0021766 ! hippocampus development +intersection_of: RO:0000052 GO:0021766 ! inheres in hippocampus development +relationship: RO:0000052 GO:0021766 ! inheres in hippocampus development [Term] id: OBA:VT0000812 @@ -172750,8 +273901,8 @@ synonym: "morphology of dentate gyrus of hippocampal formation" EXACT [AUTO:patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001885 ! dentate gyrus of hippocampal formation -relationship: inheres_in UBERON:0001885 ! dentate gyrus of hippocampal formation +intersection_of: RO:0000052 UBERON:0001885 ! inheres in dentate gyrus of hippocampal formation +relationship: RO:0000052 UBERON:0001885 ! inheres in dentate gyrus of hippocampal formation [Term] id: OBA:VT0000813 @@ -172761,8 +273912,8 @@ synonym: "morphology of layer of hippocampus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002305 ! layer of hippocampus -relationship: inheres_in UBERON:0002305 ! layer of hippocampus +intersection_of: RO:0000052 UBERON:0002305 ! inheres in layer of hippocampus +relationship: RO:0000052 UBERON:0002305 ! inheres in layer of hippocampus [Term] id: OBA:VT0000815 @@ -172772,8 +273923,8 @@ synonym: "morphology of Ammon's horn" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001954 ! Ammon's horn -relationship: inheres_in UBERON:0001954 ! Ammon's horn +intersection_of: RO:0000052 UBERON:0001954 ! inheres in Ammon's horn +relationship: RO:0000052 UBERON:0001954 ! inheres in Ammon's horn [Term] id: OBA:VT0000818 @@ -172782,8 +273933,8 @@ def: "The morphology of a amygdala." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of amygdala" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006007 ! basal ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001876 ! amygdala -relationship: inheres_in UBERON:0001876 ! amygdala +intersection_of: RO:0000052 UBERON:0001876 ! inheres in amygdala +relationship: RO:0000052 UBERON:0001876 ! inheres in amygdala [Term] id: OBA:VT0000819 @@ -172793,8 +273944,8 @@ synonym: "morphology of olfactory bulb" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002264 ! olfactory bulb -relationship: inheres_in UBERON:0002264 ! olfactory bulb +intersection_of: RO:0000052 UBERON:0002264 ! inheres in olfactory bulb +relationship: RO:0000052 UBERON:0002264 ! inheres in olfactory bulb [Term] id: OBA:VT0000820 @@ -172803,8 +273954,8 @@ def: "The morphology of a choroid plexus." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of choroid plexus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002200 ! brain ventricle/choroid plexus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001886 ! choroid plexus -relationship: inheres_in UBERON:0001886 ! choroid plexus +intersection_of: RO:0000052 UBERON:0001886 ! inheres in choroid plexus +relationship: RO:0000052 UBERON:0001886 ! inheres in choroid plexus [Term] id: OBA:VT0000822 @@ -172814,7 +273965,7 @@ synonym: "morphology of brain ventricle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000285 ! brain ventricle quality is_a: OBA:VT0002200 ! brain ventricle/choroid plexus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004086 ! brain ventricle +intersection_of: RO:0000052 UBERON:0004086 ! inheres in brain ventricle [Term] id: OBA:VT0000823 @@ -172823,8 +273974,8 @@ def: "The morphology of a telencephalic ventricle." [AUTO:patterns/patterns/enti synonym: "morphology of telencephalic ventricle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000822 ! brain ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002285 ! telencephalic ventricle -relationship: inheres_in UBERON:0002285 ! telencephalic ventricle +intersection_of: RO:0000052 UBERON:0002285 ! inheres in telencephalic ventricle +relationship: RO:0000052 UBERON:0002285 ! inheres in telencephalic ventricle [Term] id: OBA:VT0000825 @@ -172834,7 +273985,7 @@ synonym: "size of telencephalic ventricle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0002294 ! brain ventricle size is_a: OBA:VT0000823 ! lateral ventricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002285 ! telencephalic ventricle +intersection_of: RO:0000052 UBERON:0002285 ! inheres in telencephalic ventricle [Term] id: OBA:VT0000826 @@ -172844,7 +273995,7 @@ synonym: "morphology of third ventricle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000364 ! third ventricle quality is_a: OBA:VT0000822 ! brain ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002286 ! third ventricle +intersection_of: RO:0000052 UBERON:0002286 ! inheres in third ventricle [Term] id: OBA:VT0000827 @@ -172854,7 +274005,7 @@ synonym: "size of third ventricle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002294 ! brain ventricle size is_a: OBA:VT0000826 ! third ventricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002286 ! third ventricle +intersection_of: RO:0000052 UBERON:0002286 ! inheres in third ventricle [Term] id: OBA:VT0000828 @@ -172864,7 +274015,7 @@ synonym: "morphology of fourth ventricle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000467 ! fourth ventricle quality is_a: OBA:VT0000822 ! brain ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002422 ! fourth ventricle +intersection_of: RO:0000052 UBERON:0002422 ! inheres in fourth ventricle [Term] id: OBA:VT0000829 @@ -172874,7 +274025,7 @@ synonym: "size of fourth ventricle" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0002294 ! brain ventricle size is_a: OBA:VT0000828 ! fourth ventricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002422 ! fourth ventricle +intersection_of: RO:0000052 UBERON:0002422 ! inheres in fourth ventricle [Term] id: OBA:VT0000830 @@ -172884,7 +274035,7 @@ synonym: "morphology of diencephalon" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000412 ! diencephalon quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001894 ! diencephalon +intersection_of: RO:0000052 UBERON:0001894 ! inheres in diencephalon [Term] id: OBA:VT0000832 @@ -172894,8 +274045,8 @@ synonym: "morphology of dorsal plus ventral thalamus" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001897 ! dorsal plus ventral thalamus -relationship: inheres_in UBERON:0001897 ! dorsal plus ventral thalamus +intersection_of: RO:0000052 UBERON:0001897 ! inheres in dorsal plus ventral thalamus +relationship: RO:0000052 UBERON:0001897 ! inheres in dorsal plus ventral thalamus [Term] id: OBA:VT0000834 @@ -172905,8 +274056,8 @@ synonym: "morphology of ventral thalamus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001900 ! ventral thalamus -relationship: inheres_in UBERON:0001900 ! ventral thalamus +intersection_of: RO:0000052 UBERON:0001900 ! inheres in ventral thalamus +relationship: RO:0000052 UBERON:0001900 ! inheres in ventral thalamus [Term] id: OBA:VT0000835 @@ -172916,8 +274067,8 @@ synonym: "morphology of subthalamic nucleus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001906 ! subthalamic nucleus -relationship: inheres_in UBERON:0001906 ! subthalamic nucleus +intersection_of: RO:0000052 UBERON:0001906 ! inheres in subthalamic nucleus +relationship: RO:0000052 UBERON:0001906 ! inheres in subthalamic nucleus [Term] id: OBA:VT0000836 @@ -172927,7 +274078,7 @@ synonym: "morphology of substantia nigra" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000365 ! substantia nigra quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002038 ! substantia nigra +intersection_of: RO:0000052 UBERON:0002038 ! inheres in substantia nigra [Term] id: OBA:VT0000837 @@ -172937,8 +274088,8 @@ synonym: "morphology of hypothalamus" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001898 ! hypothalamus -relationship: inheres_in UBERON:0001898 ! hypothalamus +intersection_of: RO:0000052 UBERON:0001898 ! inheres in hypothalamus +relationship: RO:0000052 UBERON:0001898 ! inheres in hypothalamus [Term] id: OBA:VT0000840 @@ -172948,8 +274099,8 @@ synonym: "morphology of epithalamus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001899 ! epithalamus -relationship: inheres_in UBERON:0001899 ! epithalamus +intersection_of: RO:0000052 UBERON:0001899 ! inheres in epithalamus +relationship: RO:0000052 UBERON:0001899 ! inheres in epithalamus [Term] id: OBA:VT0000841 @@ -172959,8 +274110,8 @@ synonym: "morphology of hindbrain" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002028 ! hindbrain -relationship: inheres_in UBERON:0002028 ! hindbrain +intersection_of: RO:0000052 UBERON:0002028 ! inheres in hindbrain +relationship: RO:0000052 UBERON:0002028 ! inheres in hindbrain [Term] id: OBA:VT0000842 @@ -172970,8 +274121,8 @@ synonym: "morphology of superior olivary complex" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002128 ! superior olivary complex -relationship: inheres_in UBERON:0002128 ! superior olivary complex +intersection_of: RO:0000052 UBERON:0002128 ! inheres in superior olivary complex +relationship: RO:0000052 UBERON:0002128 ! inheres in superior olivary complex [Term] id: OBA:VT0000844 @@ -172981,8 +274132,8 @@ synonym: "morphology of pontine flexure" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005820 ! pontine flexure -relationship: inheres_in UBERON:0005820 ! pontine flexure +intersection_of: RO:0000052 UBERON:0005820 ! inheres in pontine flexure +relationship: RO:0000052 UBERON:0005820 ! inheres in pontine flexure [Term] id: OBA:VT0000846 @@ -172992,7 +274143,7 @@ synonym: "morphology of medulla oblongata" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000525 ! medulla oblongata quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001896 ! medulla oblongata +intersection_of: RO:0000052 UBERON:0001896 ! inheres in medulla oblongata [Term] id: OBA:VT0000847 @@ -173002,7 +274153,7 @@ synonym: "morphology of metencephalon" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000406 ! metencephalon quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001895 ! metencephalon +intersection_of: RO:0000052 UBERON:0001895 ! inheres in metencephalon [Term] id: OBA:VT0000848 @@ -173012,8 +274163,8 @@ synonym: "morphology of pons" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000988 ! pons -relationship: inheres_in UBERON:0000988 ! pons +intersection_of: RO:0000052 UBERON:0000988 ! inheres in pons +relationship: RO:0000052 UBERON:0000988 ! inheres in pons [Term] id: OBA:VT0000849 @@ -173023,8 +274174,8 @@ synonym: "morphology of cerebellum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002037 ! cerebellum -relationship: inheres_in UBERON:0002037 ! cerebellum +intersection_of: RO:0000052 UBERON:0002037 ! inheres in cerebellum +relationship: RO:0000052 UBERON:0002037 ! inheres in cerebellum [Term] id: OBA:VT0000852 @@ -173034,7 +274185,7 @@ synonym: "size of cerebellum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000849 ! cerebellum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002037 ! cerebellum +intersection_of: RO:0000052 UBERON:0002037 ! inheres in cerebellum [Term] id: OBA:VT0000854 @@ -173043,8 +274194,8 @@ def: "The quality of a cerebellum development." [AUTO:patterns/patterns/entity_a synonym: "quality of cerebellum development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021549 ! cerebellum development -relationship: inheres_in GO:0021549 ! cerebellum development +intersection_of: RO:0000052 GO:0021549 ! inheres in cerebellum development +relationship: RO:0000052 GO:0021549 ! inheres in cerebellum development [Term] id: OBA:VT0000856 @@ -173053,8 +274204,8 @@ def: "The morphology of a cerebellar plate." [AUTO:patterns/patterns/entity_attr synonym: "morphology of cerebellar plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004008 ! cerebellar plate -relationship: inheres_in UBERON:0004008 ! cerebellar plate +intersection_of: RO:0000052 UBERON:0004008 ! inheres in cerebellar plate +relationship: RO:0000052 UBERON:0004008 ! inheres in cerebellar plate [Term] id: OBA:VT0000859 @@ -173064,8 +274215,8 @@ synonym: "morphology of somatosensory cortex" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008930 ! somatosensory cortex -relationship: inheres_in UBERON:0008930 ! somatosensory cortex +intersection_of: RO:0000052 UBERON:0008930 ! inheres in somatosensory cortex +relationship: RO:0000052 UBERON:0008930 ! inheres in somatosensory cortex [Term] id: OBA:VT0000860 @@ -173074,8 +274225,8 @@ def: "The morphology of a primary somatosensory cortex." [AUTO:patterns/patterns synonym: "morphology of primary somatosensory cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000859 ! somatosensory cortex morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008933 ! primary somatosensory cortex -relationship: inheres_in UBERON:0008933 ! primary somatosensory cortex +intersection_of: RO:0000052 UBERON:0008933 ! inheres in primary somatosensory cortex +relationship: RO:0000052 UBERON:0008933 ! inheres in primary somatosensory cortex [Term] id: OBA:VT0000863 @@ -173084,8 +274235,8 @@ def: "The morphology of a secondary somatosensory cortex." [AUTO:patterns/patter synonym: "morphology of secondary somatosensory cortex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000859 ! somatosensory cortex morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008934 ! secondary somatosensory cortex -relationship: inheres_in UBERON:0008934 ! secondary somatosensory cortex +intersection_of: RO:0000052 UBERON:0008934 ! inheres in secondary somatosensory cortex +relationship: RO:0000052 UBERON:0008934 ! inheres in secondary somatosensory cortex [Term] id: OBA:VT0000864 @@ -173095,8 +274246,8 @@ synonym: "morphology of cerebellar vermis" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004720 ! cerebellar vermis -relationship: inheres_in UBERON:0004720 ! cerebellar vermis +intersection_of: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis +relationship: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis [Term] id: OBA:VT0000865 @@ -173106,7 +274257,7 @@ synonym: "size of cerebellar vermis" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000864 ! cerebellum vermis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004720 ! cerebellar vermis +intersection_of: RO:0000052 UBERON:0004720 ! inheres in cerebellar vermis [Term] id: OBA:VT0000867 @@ -173115,8 +274266,8 @@ def: "The morphology of a cerebellum anterior vermis." [AUTO:patterns/patterns/e synonym: "morphology of cerebellum anterior vermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000864 ! cerebellum vermis morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003941 ! cerebellum anterior vermis -relationship: inheres_in UBERON:0003941 ! cerebellum anterior vermis +intersection_of: RO:0000052 UBERON:0003941 ! inheres in cerebellum anterior vermis +relationship: RO:0000052 UBERON:0003941 ! inheres in cerebellum anterior vermis [Term] id: OBA:VT0000868 @@ -173126,7 +274277,7 @@ synonym: "size of cerebellum anterior vermis" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0000865 ! cerebellum vermis size trait is_a: OBA:VT0000867 ! cerebellum anterior vermis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003941 ! cerebellum anterior vermis +intersection_of: RO:0000052 UBERON:0003941 ! inheres in cerebellum anterior vermis [Term] id: OBA:VT0000869 @@ -173135,8 +274286,8 @@ def: "The morphology of a cerebellum posterior vermis." [AUTO:patterns/patterns/ synonym: "morphology of cerebellum posterior vermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000864 ! cerebellum vermis morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004009 ! cerebellum posterior vermis -relationship: inheres_in UBERON:0004009 ! cerebellum posterior vermis +intersection_of: RO:0000052 UBERON:0004009 ! inheres in cerebellum posterior vermis +relationship: RO:0000052 UBERON:0004009 ! inheres in cerebellum posterior vermis [Term] id: OBA:VT0000870 @@ -173145,8 +274296,8 @@ def: "The morphology of a cerebellum vermis lobule VIII." [AUTO:patterns/pattern synonym: "morphology of cerebellum vermis lobule VIII" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004082 ! cerebellum vermis lobule VIII -relationship: inheres_in UBERON:0004082 ! cerebellum vermis lobule VIII +intersection_of: RO:0000052 UBERON:0004082 ! inheres in cerebellum vermis lobule VIII +relationship: RO:0000052 UBERON:0004082 ! inheres in cerebellum vermis lobule VIII [Term] id: OBA:VT0000871 @@ -173155,8 +274306,8 @@ def: "The morphology of a cerebellum vermis lobule IX." [AUTO:patterns/patterns/ synonym: "morphology of cerebellum vermis lobule IX" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015085 ! cerebellum vermis lobule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004078 ! cerebellum vermis lobule IX -relationship: inheres_in UBERON:0004078 ! cerebellum vermis lobule IX +intersection_of: RO:0000052 UBERON:0004078 ! inheres in cerebellum vermis lobule IX +relationship: RO:0000052 UBERON:0004078 ! inheres in cerebellum vermis lobule IX [Term] id: OBA:VT0000872 @@ -173165,8 +274316,8 @@ def: "The morphology of a cerebellum external granule cell layer." [AUTO:pattern synonym: "morphology of cerebellum external granule cell layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000886 ! cerebellar granule layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008829 ! cerebellum external granule cell layer -relationship: inheres_in UBERON:0008829 ! cerebellum external granule cell layer +intersection_of: RO:0000052 UBERON:0008829 ! inheres in cerebellum external granule cell layer +relationship: RO:0000052 UBERON:0008829 ! inheres in cerebellum external granule cell layer [Term] id: OBA:VT0000873 @@ -173176,7 +274327,7 @@ synonym: "thickness of cerebellum external granule cell layer" EXACT [AUTO:patte is_a: OBA:0003558 ! cerebellum external granule cell layer size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0008829 ! cerebellum external granule cell layer +intersection_of: RO:0000052 UBERON:0008829 ! inheres in cerebellum external granule cell layer [Term] id: OBA:VT0000875 @@ -173186,7 +274337,7 @@ synonym: "morphology of Purkinje cell layer of cerebellar cortex" EXACT [AUTO:pa is_a: OBA:0004929 ! cerebellar layer morphology is_a: OBA:1000783 ! Purkinje cell layer of cerebellar cortex quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002979 ! Purkinje cell layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002979 ! inheres in Purkinje cell layer of cerebellar cortex [Term] id: OBA:VT0000877 @@ -173195,8 +274346,8 @@ def: "The morphology of a Purkinje cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of Purkinje cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000121 ! Purkinje cell -relationship: inheres_in CL:0000121 ! Purkinje cell +intersection_of: RO:0000052 CL:0000121 ! inheres in Purkinje cell +relationship: RO:0000052 CL:0000121 ! inheres in Purkinje cell [Term] id: OBA:VT0000878 @@ -173206,8 +274357,8 @@ synonym: "has number of of Purkinje cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000121 ! Purkinje cell -relationship: inheres_in CL:0000121 ! Purkinje cell +intersection_of: RO:0000052 CL:0000121 ! inheres in Purkinje cell +relationship: RO:0000052 CL:0000121 ! inheres in Purkinje cell [Term] id: OBA:VT0000886 @@ -173217,7 +274368,7 @@ synonym: "morphology of granular layer of cerebellar cortex" EXACT [AUTO:pattern is_a: OBA:0004929 ! cerebellar layer morphology is_a: OBA:1000824 ! granular layer of cerebellar cortex quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002956 ! granular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002956 ! inheres in granular layer of cerebellar cortex [Term] id: OBA:VT0000889 @@ -173227,7 +274378,7 @@ synonym: "morphology of molecular layer of cerebellar cortex" EXACT [AUTO:patter is_a: OBA:0004929 ! cerebellar layer morphology is_a: OBA:1000659 ! molecular layer of cerebellar cortex quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002974 ! molecular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002974 ! inheres in molecular layer of cerebellar cortex [Term] id: OBA:VT0000890 @@ -173237,7 +274388,7 @@ synonym: "thickness of molecular layer of cerebellar cortex" EXACT [AUTO:pattern is_a: OBA:0003564 ! molecular layer of cerebellar cortex size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002974 ! molecular layer of cerebellar cortex +intersection_of: RO:0000052 UBERON:0002974 ! inheres in molecular layer of cerebellar cortex [Term] id: OBA:VT0000897 @@ -173247,8 +274398,8 @@ synonym: "morphology of midbrain" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001891 ! midbrain -relationship: inheres_in UBERON:0001891 ! midbrain +intersection_of: RO:0000052 UBERON:0001891 ! inheres in midbrain +relationship: RO:0000052 UBERON:0001891 ! inheres in midbrain [Term] id: OBA:VT0000899 @@ -173258,8 +274409,8 @@ synonym: "morphology of corpora quadrigemina" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002259 ! corpora quadrigemina -relationship: inheres_in UBERON:0002259 ! corpora quadrigemina +intersection_of: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina +relationship: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina [Term] id: OBA:VT0000900 @@ -173269,7 +274420,7 @@ synonym: "size of corpora quadrigemina" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000899 ! corpora quadrigemina morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002259 ! corpora quadrigemina +intersection_of: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina [Term] id: OBA:VT0000901 @@ -173279,8 +274430,8 @@ synonym: "position of corpora quadrigemina" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0002259 ! corpora quadrigemina -relationship: inheres_in UBERON:0002259 ! corpora quadrigemina +intersection_of: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina +relationship: RO:0000052 UBERON:0002259 ! inheres in corpora quadrigemina [Term] id: OBA:VT0000904 @@ -173290,7 +274441,7 @@ synonym: "morphology of superior colliculus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000810 ! superior colliculus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001945 ! superior colliculus +intersection_of: RO:0000052 UBERON:0001945 ! inheres in superior colliculus [Term] id: OBA:VT0000905 @@ -173300,7 +274451,7 @@ synonym: "size of superior colliculus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000904 ! superior colliculus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001945 ! superior colliculus +intersection_of: RO:0000052 UBERON:0001945 ! inheres in superior colliculus [Term] id: OBA:VT0000906 @@ -173310,8 +274461,8 @@ synonym: "morphology of mesencephalic nucleus of trigeminal nerve" EXACT [AUTO:p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001718 ! mesencephalic nucleus of trigeminal nerve -relationship: inheres_in UBERON:0001718 ! mesencephalic nucleus of trigeminal nerve +intersection_of: RO:0000052 UBERON:0001718 ! inheres in mesencephalic nucleus of trigeminal nerve +relationship: RO:0000052 UBERON:0001718 ! inheres in mesencephalic nucleus of trigeminal nerve [Term] id: OBA:VT0000907 @@ -173321,7 +274472,7 @@ synonym: "size of mesencephalic nucleus of trigeminal nerve" EXACT [AUTO:pattern is_a: OBA:VT0000906 ! trigeminal V mesencephalic nucleus morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001718 ! mesencephalic nucleus of trigeminal nerve +intersection_of: RO:0000052 UBERON:0001718 ! inheres in mesencephalic nucleus of trigeminal nerve [Term] id: OBA:VT0000909 @@ -173330,8 +274481,8 @@ def: "The morphology of a facial motor nucleus." [AUTO:patterns/patterns/entity_ synonym: "morphology of facial motor nucleus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003566 ! facial nucleus morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003011 ! facial motor nucleus -relationship: inheres_in UBERON:0003011 ! facial motor nucleus +intersection_of: RO:0000052 UBERON:0003011 ! inheres in facial motor nucleus +relationship: RO:0000052 UBERON:0003011 ! inheres in facial motor nucleus [Term] id: OBA:VT0000910 @@ -173341,7 +274492,7 @@ synonym: "size of facial motor nucleus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003567 ! facial nucleus size is_a: OBA:VT0000909 ! facial motor nucleus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003011 ! facial motor nucleus +intersection_of: RO:0000052 UBERON:0003011 ! inheres in facial motor nucleus [Term] id: OBA:VT0000911 @@ -173351,8 +274502,8 @@ synonym: "morphology of motor nucleus of trigeminal nerve" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002633 ! motor nucleus of trigeminal nerve -relationship: inheres_in UBERON:0002633 ! motor nucleus of trigeminal nerve +intersection_of: RO:0000052 UBERON:0002633 ! inheres in motor nucleus of trigeminal nerve +relationship: RO:0000052 UBERON:0002633 ! inheres in motor nucleus of trigeminal nerve [Term] id: OBA:VT0000912 @@ -173362,7 +274513,7 @@ synonym: "size of motor nucleus of trigeminal nerve" EXACT [AUTO:patterns/patter is_a: OBA:VT0000911 ! trigeminal motor nucleus morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002633 ! motor nucleus of trigeminal nerve +intersection_of: RO:0000052 UBERON:0002633 ! inheres in motor nucleus of trigeminal nerve [Term] id: OBA:VT0000913 @@ -173371,8 +274522,8 @@ def: "The quality of a brain development." [AUTO:patterns/patterns/entity_attrib synonym: "quality of brain development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007420 ! brain development -relationship: inheres_in GO:0007420 ! brain development +intersection_of: RO:0000052 GO:0007420 ! inheres in brain development +relationship: RO:0000052 GO:0007420 ! inheres in brain development [Term] id: OBA:VT0000920 @@ -173381,8 +274532,8 @@ def: "The quality of a myelination." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of myelination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042552 ! myelination -relationship: inheres_in GO:0042552 ! myelination +intersection_of: RO:0000052 GO:0042552 ! inheres in myelination +relationship: RO:0000052 GO:0042552 ! inheres in myelination [Term] id: OBA:VT0000923 @@ -173391,8 +274542,8 @@ def: "The morphology of a roof plate." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of roof plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003054 ! roof plate -relationship: inheres_in UBERON:0003054 ! roof plate +intersection_of: RO:0000052 UBERON:0003054 ! inheres in roof plate +relationship: RO:0000052 UBERON:0003054 ! inheres in roof plate [Term] id: OBA:VT0000925 @@ -173401,8 +274552,8 @@ def: "The morphology of a floor plate." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of floor plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003079 ! floor plate -relationship: inheres_in UBERON:0003079 ! floor plate +intersection_of: RO:0000052 UBERON:0003079 ! inheres in floor plate +relationship: RO:0000052 UBERON:0003079 ! inheres in floor plate [Term] id: OBA:VT0000927 @@ -173412,7 +274563,7 @@ synonym: "size of floor plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000925 ! floor plate morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003079 ! floor plate +intersection_of: RO:0000052 UBERON:0003079 ! inheres in floor plate [Term] id: OBA:VT0000933 @@ -173421,8 +274572,8 @@ def: "The morphology of a rhombomere." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of rhombomere" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003208 ! neuromere morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001892 ! rhombomere -relationship: inheres_in UBERON:0001892 ! rhombomere +intersection_of: RO:0000052 UBERON:0001892 ! inheres in rhombomere +relationship: RO:0000052 UBERON:0001892 ! inheres in rhombomere [Term] id: OBA:VT0000934 @@ -173431,8 +274582,8 @@ def: "The quality of a telencephalon development." [AUTO:patterns/patterns/entit synonym: "quality of telencephalon development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021537 ! telencephalon development -relationship: inheres_in GO:0021537 ! telencephalon development +intersection_of: RO:0000052 GO:0021537 ! inheres in telencephalon development +relationship: RO:0000052 GO:0021537 ! inheres in telencephalon development [Term] id: OBA:VT0000936 @@ -173442,7 +274593,7 @@ synonym: "size of cerebral hemisphere" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:0004450 ! cerebral hemisphere morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001869 ! cerebral hemisphere +intersection_of: RO:0000052 UBERON:0001869 ! inheres in cerebral hemisphere [Term] id: OBA:VT0000937 @@ -173451,8 +274602,8 @@ def: "The morphology of a motor neuron." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of motor neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000100 ! motor neuron -relationship: inheres_in CL:0000100 ! motor neuron +intersection_of: RO:0000052 CL:0000100 ! inheres in motor neuron +relationship: RO:0000052 CL:0000100 ! inheres in motor neuron [Term] id: OBA:VT0000939 @@ -173462,8 +274613,8 @@ synonym: "has number of of motor neuron" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000100 ! motor neuron -relationship: inheres_in CL:0000100 ! motor neuron +intersection_of: RO:0000052 CL:0000100 ! inheres in motor neuron +relationship: RO:0000052 CL:0000100 ! inheres in motor neuron [Term] id: OBA:VT0000953 @@ -173473,7 +274624,7 @@ synonym: "morphology of oligodendrocyte" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000238 ! oligodendrocyte quality is_a: OBA:VT0003634 ! glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:VT0000955 @@ -173483,8 +274634,8 @@ synonym: "morphology of spinal cord" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002240 ! spinal cord -relationship: inheres_in UBERON:0002240 ! spinal cord +intersection_of: RO:0000052 UBERON:0002240 ! inheres in spinal cord +relationship: RO:0000052 UBERON:0002240 ! inheres in spinal cord [Term] id: OBA:VT0000959 @@ -173494,8 +274645,8 @@ synonym: "morphology of somatic sensory system" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003942 ! somatic sensory system -relationship: inheres_in UBERON:0003942 ! somatic sensory system +intersection_of: RO:0000052 UBERON:0003942 ! inheres in somatic sensory system +relationship: RO:0000052 UBERON:0003942 ! inheres in somatic sensory system [Term] id: OBA:VT0000960 @@ -173505,8 +274656,8 @@ synonym: "morphology of sensory ganglion" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000529 ! ganglion quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001800 ! sensory ganglion -relationship: inheres_in UBERON:0001800 ! sensory ganglion +intersection_of: RO:0000052 UBERON:0001800 ! inheres in sensory ganglion +relationship: RO:0000052 UBERON:0001800 ! inheres in sensory ganglion [Term] id: OBA:VT0000961 @@ -173515,8 +274666,8 @@ def: "The morphology of a dorsal root ganglion." [AUTO:patterns/patterns/entity_ synonym: "morphology of dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000960 ! sensory ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000044 ! dorsal root ganglion -relationship: inheres_in UBERON:0000044 ! dorsal root ganglion +intersection_of: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion +relationship: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion [Term] id: OBA:VT0000964 @@ -173526,7 +274677,7 @@ synonym: "size of dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000961 ! dorsal root ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000044 ! dorsal root ganglion +intersection_of: RO:0000052 UBERON:0000044 ! inheres in dorsal root ganglion [Term] id: OBA:VT0000965 @@ -173535,8 +274686,8 @@ def: "The morphology of a sensory neuron." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of sensory neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000101 ! sensory neuron -relationship: inheres_in CL:0000101 ! sensory neuron +intersection_of: RO:0000052 CL:0000101 ! inheres in sensory neuron +relationship: RO:0000052 CL:0000101 ! inheres in sensory neuron [Term] id: OBA:VT0000969 @@ -173545,8 +274696,8 @@ def: "The morphology of a pain receptor cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of pain receptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000198 ! pain receptor cell -relationship: inheres_in CL:0000198 ! pain receptor cell +intersection_of: RO:0000052 CL:0000198 ! inheres in pain receptor cell +relationship: RO:0000052 CL:0000198 ! inheres in pain receptor cell [Term] id: OBA:VT0000971 @@ -173556,8 +274707,8 @@ synonym: "morphology of thermoreceptor" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0035018 ! thermoreceptor -relationship: inheres_in UBERON:0035018 ! thermoreceptor +intersection_of: RO:0000052 UBERON:0035018 ! inheres in thermoreceptor +relationship: RO:0000052 UBERON:0035018 ! inheres in thermoreceptor [Term] id: OBA:VT0000972 @@ -173567,8 +274718,8 @@ synonym: "morphology of mechanoreceptor" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012449 ! mechanoreceptor -relationship: inheres_in UBERON:0012449 ! mechanoreceptor +intersection_of: RO:0000052 UBERON:0012449 ! inheres in mechanoreceptor +relationship: RO:0000052 UBERON:0012449 ! inheres in mechanoreceptor [Term] id: OBA:VT0000982 @@ -173577,8 +274728,8 @@ def: "The morphology of a Meissner's corpuscle." [AUTO:patterns/patterns/entity_ synonym: "morphology of Meissner's corpuscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000972 ! mechanoreceptor morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012450 ! Meissner's corpuscle -relationship: inheres_in UBERON:0012450 ! Meissner's corpuscle +intersection_of: RO:0000052 UBERON:0012450 ! inheres in Meissner's corpuscle +relationship: RO:0000052 UBERON:0012450 ! inheres in Meissner's corpuscle [Term] id: OBA:VT0000983 @@ -173588,7 +274739,7 @@ synonym: "size of Meissner's corpuscle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000982 ! Meissner's corpuscle morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012450 ! Meissner's corpuscle +intersection_of: RO:0000052 UBERON:0012450 ! inheres in Meissner's corpuscle [Term] id: OBA:VT0000985 @@ -173597,8 +274748,8 @@ def: "The morphology of a Merkel nerve ending." [AUTO:patterns/patterns/entity_a synonym: "morphology of Merkel nerve ending" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000972 ! mechanoreceptor morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012456 ! Merkel nerve ending -relationship: inheres_in UBERON:0012456 ! Merkel nerve ending +intersection_of: RO:0000052 UBERON:0012456 ! inheres in Merkel nerve ending +relationship: RO:0000052 UBERON:0012456 ! inheres in Merkel nerve ending [Term] id: OBA:VT0000986 @@ -173608,8 +274759,8 @@ synonym: "amount of Merkel nerve ending" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0012456 ! Merkel nerve ending -relationship: inheres_in UBERON:0012456 ! Merkel nerve ending +intersection_of: RO:0000052 UBERON:0012456 ! inheres in Merkel nerve ending +relationship: RO:0000052 UBERON:0012456 ! inheres in Merkel nerve ending [Term] id: OBA:VT0000988 @@ -173618,8 +274769,8 @@ def: "The morphology of a Pacinian corpuscle." [AUTO:patterns/patterns/entity_at synonym: "morphology of Pacinian corpuscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000972 ! mechanoreceptor morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003719 ! Pacinian corpuscle -relationship: inheres_in UBERON:0003719 ! Pacinian corpuscle +intersection_of: RO:0000052 UBERON:0003719 ! inheres in Pacinian corpuscle +relationship: RO:0000052 UBERON:0003719 ! inheres in Pacinian corpuscle [Term] id: OBA:VT0000989 @@ -173628,8 +274779,8 @@ def: "The morphology of a Ruffini nerve ending." [AUTO:patterns/patterns/entity_ synonym: "morphology of Ruffini nerve ending" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000972 ! mechanoreceptor morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012457 ! Ruffini nerve ending -relationship: inheres_in UBERON:0012457 ! Ruffini nerve ending +intersection_of: RO:0000052 UBERON:0012457 ! inheres in Ruffini nerve ending +relationship: RO:0000052 UBERON:0012457 ! inheres in Ruffini nerve ending [Term] id: OBA:VT0000991 @@ -173638,8 +274789,8 @@ def: "The morphology of a primary muscle spindle." [AUTO:patterns/patterns/entit synonym: "morphology of primary muscle spindle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004069 ! muscle spindle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004010 ! primary muscle spindle -relationship: inheres_in UBERON:0004010 ! primary muscle spindle +intersection_of: RO:0000052 UBERON:0004010 ! inheres in primary muscle spindle +relationship: RO:0000052 UBERON:0004010 ! inheres in primary muscle spindle [Term] id: OBA:VT0000992 @@ -173649,7 +274800,7 @@ synonym: "size of primary muscle spindle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000991 ! primary muscle spindle morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004010 ! primary muscle spindle +intersection_of: RO:0000052 UBERON:0004010 ! inheres in primary muscle spindle [Term] id: OBA:VT0000994 @@ -173658,8 +274809,8 @@ def: "The morphology of a secondary muscle spindle." [AUTO:patterns/patterns/ent synonym: "morphology of secondary muscle spindle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004069 ! muscle spindle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004011 ! secondary muscle spindle -relationship: inheres_in UBERON:0004011 ! secondary muscle spindle +intersection_of: RO:0000052 UBERON:0004011 ! inheres in secondary muscle spindle +relationship: RO:0000052 UBERON:0004011 ! inheres in secondary muscle spindle [Term] id: OBA:VT0000995 @@ -173669,7 +274820,7 @@ synonym: "size of secondary muscle spindle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0000994 ! secondary muscle spindle morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004011 ! secondary muscle spindle +intersection_of: RO:0000052 UBERON:0004011 ! inheres in secondary muscle spindle [Term] id: OBA:VT0000997 @@ -173679,8 +274830,8 @@ synonym: "morphology of articular capsule" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001484 ! articular capsule -relationship: inheres_in UBERON:0001484 ! articular capsule +intersection_of: RO:0000052 UBERON:0001484 ! inheres in articular capsule +relationship: RO:0000052 UBERON:0001484 ! inheres in articular capsule [Term] id: OBA:VT0000999 @@ -173690,8 +274841,8 @@ synonym: "morphology of golgi tendon organ" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004012 ! golgi tendon organ -relationship: inheres_in UBERON:0004012 ! golgi tendon organ +intersection_of: RO:0000052 UBERON:0004012 ! inheres in golgi tendon organ +relationship: RO:0000052 UBERON:0004012 ! inheres in golgi tendon organ [Term] id: OBA:VT0001001 @@ -173701,8 +274852,8 @@ synonym: "morphology of chemoreceptor" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0018391 ! chemoreceptor -relationship: inheres_in UBERON:0018391 ! chemoreceptor +intersection_of: RO:0000052 UBERON:0018391 ! inheres in chemoreceptor +relationship: RO:0000052 UBERON:0018391 ! inheres in chemoreceptor [Term] id: OBA:VT0001002 @@ -173711,8 +274862,8 @@ def: "The morphology of a taste bud." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of taste bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005499 ! olfactory system morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001727 ! taste bud -relationship: inheres_in UBERON:0001727 ! taste bud +intersection_of: RO:0000052 UBERON:0001727 ! inheres in taste bud +relationship: RO:0000052 UBERON:0001727 ! inheres in taste bud [Term] id: OBA:VT0001005 @@ -173721,8 +274872,8 @@ def: "The morphology of a retinal rod cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of retinal rod cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003590 ! eye photoreceptor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000604 ! retinal rod cell -relationship: inheres_in CL:0000604 ! retinal rod cell +intersection_of: RO:0000052 CL:0000604 ! inheres in retinal rod cell +relationship: RO:0000052 CL:0000604 ! inheres in retinal rod cell [Term] id: OBA:VT0001006 @@ -173731,8 +274882,8 @@ def: "The morphology of a retinal cone cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of retinal cone cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003590 ! eye photoreceptor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000573 ! retinal cone cell -relationship: inheres_in CL:0000573 ! retinal cone cell +intersection_of: RO:0000052 CL:0000573 ! inheres in retinal cone cell +relationship: RO:0000052 CL:0000573 ! inheres in retinal cone cell [Term] id: OBA:VT0001007 @@ -173742,8 +274893,8 @@ synonym: "morphology of sympathetic nervous system" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000013 ! sympathetic nervous system -relationship: inheres_in UBERON:0000013 ! sympathetic nervous system +intersection_of: RO:0000052 UBERON:0000013 ! inheres in sympathetic nervous system +relationship: RO:0000052 UBERON:0000013 ! inheres in sympathetic nervous system [Term] id: OBA:VT0001008 @@ -173753,8 +274904,8 @@ synonym: "morphology of sympathetic ganglion" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000531 ! ganglion of peripheral nervous system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001806 ! sympathetic ganglion -relationship: inheres_in UBERON:0001806 ! sympathetic ganglion +intersection_of: RO:0000052 UBERON:0001806 ! inheres in sympathetic ganglion +relationship: RO:0000052 UBERON:0001806 ! inheres in sympathetic ganglion [Term] id: OBA:VT0001011 @@ -173763,8 +274914,8 @@ def: "The morphology of a superior cervical ganglion." [AUTO:patterns/patterns/e synonym: "morphology of superior cervical ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015050 ! paravertebral ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001989 ! superior cervical ganglion -relationship: inheres_in UBERON:0001989 ! superior cervical ganglion +intersection_of: RO:0000052 UBERON:0001989 ! inheres in superior cervical ganglion +relationship: RO:0000052 UBERON:0001989 ! inheres in superior cervical ganglion [Term] id: OBA:VT0001013 @@ -173774,7 +274925,7 @@ synonym: "size of superior cervical ganglion" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001011 ! superior cervical ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001989 ! superior cervical ganglion +intersection_of: RO:0000052 UBERON:0001989 ! inheres in superior cervical ganglion [Term] id: OBA:VT0001016 @@ -173783,8 +274934,8 @@ def: "The morphology of a middle cervical ganglion." [AUTO:patterns/patterns/ent synonym: "morphology of middle cervical ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015050 ! paravertebral ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001990 ! middle cervical ganglion -relationship: inheres_in UBERON:0001990 ! middle cervical ganglion +intersection_of: RO:0000052 UBERON:0001990 ! inheres in middle cervical ganglion +relationship: RO:0000052 UBERON:0001990 ! inheres in middle cervical ganglion [Term] id: OBA:VT0001017 @@ -173793,8 +274944,8 @@ def: "The morphology of a cervicothoracic ganglion." [AUTO:patterns/patterns/ent synonym: "morphology of cervicothoracic ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015050 ! paravertebral ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002441 ! cervicothoracic ganglion -relationship: inheres_in UBERON:0002441 ! cervicothoracic ganglion +intersection_of: RO:0000052 UBERON:0002441 ! inheres in cervicothoracic ganglion +relationship: RO:0000052 UBERON:0002441 ! inheres in cervicothoracic ganglion [Term] id: OBA:VT0001019 @@ -173803,8 +274954,8 @@ def: "The morphology of a fourth lumbar dorsal root ganglion." [AUTO:patterns/pa synonym: "morphology of fourth lumbar dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015054 ! lumbar dorsal root ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003943 ! fourth lumbar dorsal root ganglion -relationship: inheres_in UBERON:0003943 ! fourth lumbar dorsal root ganglion +intersection_of: RO:0000052 UBERON:0003943 ! inheres in fourth lumbar dorsal root ganglion +relationship: RO:0000052 UBERON:0003943 ! inheres in fourth lumbar dorsal root ganglion [Term] id: OBA:VT0001020 @@ -173814,7 +274965,7 @@ synonym: "size of fourth lumbar dorsal root ganglion" EXACT [AUTO:patterns/patte is_a: OBA:VT0000964 ! dorsal root ganglion size trait is_a: OBA:VT0001019 ! L4 dorsal root ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003943 ! fourth lumbar dorsal root ganglion +intersection_of: RO:0000052 UBERON:0003943 ! inheres in fourth lumbar dorsal root ganglion [Term] id: OBA:VT0001022 @@ -173823,8 +274974,8 @@ def: "The morphology of a fifth lumbar dorsal root ganglion." [AUTO:patterns/pat synonym: "morphology of fifth lumbar dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015054 ! lumbar dorsal root ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002859 ! fifth lumbar dorsal root ganglion -relationship: inheres_in UBERON:0002859 ! fifth lumbar dorsal root ganglion +intersection_of: RO:0000052 UBERON:0002859 ! inheres in fifth lumbar dorsal root ganglion +relationship: RO:0000052 UBERON:0002859 ! inheres in fifth lumbar dorsal root ganglion [Term] id: OBA:VT0001023 @@ -173834,7 +274985,7 @@ synonym: "size of fifth lumbar dorsal root ganglion" EXACT [AUTO:patterns/patter is_a: OBA:VT0000964 ! dorsal root ganglion size trait is_a: OBA:VT0001022 ! L5 dorsal root ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002859 ! fifth lumbar dorsal root ganglion +intersection_of: RO:0000052 UBERON:0002859 ! inheres in fifth lumbar dorsal root ganglion [Term] id: OBA:VT0001026 @@ -173843,8 +274994,8 @@ def: "The morphology of a adrenergic neuron." [AUTO:patterns/patterns/entity_att synonym: "morphology of adrenergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000109 ! adrenergic neuron -relationship: inheres_in CL:0000109 ! adrenergic neuron +intersection_of: RO:0000052 CL:0000109 ! inheres in adrenergic neuron +relationship: RO:0000052 CL:0000109 ! inheres in adrenergic neuron [Term] id: OBA:VT0001032 @@ -173853,8 +275004,8 @@ def: "The morphology of a peptidergic neuron." [AUTO:patterns/patterns/entity_at synonym: "morphology of peptidergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000110 ! peptidergic neuron -relationship: inheres_in CL:0000110 ! peptidergic neuron +intersection_of: RO:0000052 CL:0000110 ! inheres in peptidergic neuron +relationship: RO:0000052 CL:0000110 ! inheres in peptidergic neuron [Term] id: OBA:VT0001033 @@ -173864,8 +275015,8 @@ synonym: "morphology of parasympathetic nervous system" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000011 ! parasympathetic nervous system -relationship: inheres_in UBERON:0000011 ! parasympathetic nervous system +intersection_of: RO:0000052 UBERON:0000011 ! inheres in parasympathetic nervous system +relationship: RO:0000052 UBERON:0000011 ! inheres in parasympathetic nervous system [Term] id: OBA:VT0001034 @@ -173875,8 +275026,8 @@ synonym: "morphology of parasympathetic ganglion" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000531 ! ganglion of peripheral nervous system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001808 ! parasympathetic ganglion -relationship: inheres_in UBERON:0001808 ! parasympathetic ganglion +intersection_of: RO:0000052 UBERON:0001808 ! inheres in parasympathetic ganglion +relationship: RO:0000052 UBERON:0001808 ! inheres in parasympathetic ganglion [Term] id: OBA:VT0001035 @@ -173885,8 +275036,8 @@ def: "The morphology of a submandibular ganglion." [AUTO:patterns/patterns/entit synonym: "morphology of submandibular ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002059 ! submandibular ganglion -relationship: inheres_in UBERON:0002059 ! submandibular ganglion +intersection_of: RO:0000052 UBERON:0002059 ! inheres in submandibular ganglion +relationship: RO:0000052 UBERON:0002059 ! inheres in submandibular ganglion [Term] id: OBA:VT0001036 @@ -173896,7 +275047,7 @@ synonym: "size of submandibular ganglion" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001035 ! submandibular ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002059 ! submandibular ganglion +intersection_of: RO:0000052 UBERON:0002059 ! inheres in submandibular ganglion [Term] id: OBA:VT0001038 @@ -173905,8 +275056,8 @@ def: "The morphology of a cholinergic neuron." [AUTO:patterns/patterns/entity_at synonym: "morphology of cholinergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000108 ! cholinergic neuron -relationship: inheres_in CL:0000108 ! cholinergic neuron +intersection_of: RO:0000052 CL:0000108 ! inheres in cholinergic neuron +relationship: RO:0000052 CL:0000108 ! inheres in cholinergic neuron [Term] id: OBA:VT0001044 @@ -173916,8 +275067,8 @@ synonym: "morphology of enteric nervous system" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002005 ! enteric nervous system -relationship: inheres_in UBERON:0002005 ! enteric nervous system +intersection_of: RO:0000052 UBERON:0002005 ! inheres in enteric nervous system +relationship: RO:0000052 UBERON:0002005 ! inheres in enteric nervous system [Term] id: OBA:VT0001045 @@ -173926,8 +275077,8 @@ def: "The morphology of a enteric ganglion." [AUTO:patterns/patterns/entity_attr synonym: "morphology of enteric ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001809 ! enteric ganglion -relationship: inheres_in UBERON:0001809 ! enteric ganglion +intersection_of: RO:0000052 UBERON:0001809 ! inheres in enteric ganglion +relationship: RO:0000052 UBERON:0001809 ! inheres in enteric ganglion [Term] id: OBA:VT0001046 @@ -173936,8 +275087,8 @@ def: "The morphology of a enteric neuron." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of enteric neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003592 ! autonomic neuron morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0007011 ! enteric neuron -relationship: inheres_in CL:0007011 ! enteric neuron +intersection_of: RO:0000052 CL:0007011 ! inheres in enteric neuron +relationship: RO:0000052 CL:0007011 ! inheres in enteric neuron [Term] id: OBA:VT0001048 @@ -173946,8 +275097,8 @@ def: "The amount of a enteric neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of enteric neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0007011 ! enteric neuron -relationship: inheres_in CL:0007011 ! enteric neuron +intersection_of: RO:0000052 CL:0007011 ! inheres in enteric neuron +relationship: RO:0000052 CL:0007011 ! inheres in enteric neuron [Term] id: OBA:VT0001051 @@ -173957,8 +275108,8 @@ synonym: "morphology of somatic motor system" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003945 ! somatic motor system -relationship: inheres_in UBERON:0003945 ! somatic motor system +intersection_of: RO:0000052 UBERON:0003945 ! inheres in somatic motor system +relationship: RO:0000052 UBERON:0003945 ! inheres in somatic motor system [Term] id: OBA:VT0001053 @@ -173967,8 +275118,8 @@ def: "The morphology of a neuromuscular junction." [AUTO:patterns/patterns/entit synonym: "morphology of neuromuscular junction" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015110 ! synapse morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0031594 ! neuromuscular junction -relationship: inheres_in GO:0031594 ! neuromuscular junction +intersection_of: RO:0000052 GO:0031594 ! inheres in neuromuscular junction +relationship: RO:0000052 GO:0031594 ! inheres in neuromuscular junction [Term] id: OBA:VT0001056 @@ -173978,8 +275129,8 @@ synonym: "morphology of cranial nerve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001785 ! cranial nerve -relationship: inheres_in UBERON:0001785 ! cranial nerve +intersection_of: RO:0000052 UBERON:0001785 ! inheres in cranial nerve +relationship: RO:0000052 UBERON:0001785 ! inheres in cranial nerve [Term] id: OBA:VT0001059 @@ -173989,7 +275140,7 @@ synonym: "size of neuron projection bundle connecting eye with brain" EXACT [AUT is_a: OBA:VT0001330 ! optic nerve morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004904 ! neuron projection bundle connecting eye with brain +intersection_of: RO:0000052 UBERON:0004904 ! inheres in neuron projection bundle connecting eye with brain [Term] id: OBA:VT0001061 @@ -173998,8 +275149,8 @@ def: "The morphology of a oculomotor nerve." [AUTO:patterns/patterns/entity_attr synonym: "morphology of oculomotor nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001643 ! oculomotor nerve -relationship: inheres_in UBERON:0001643 ! oculomotor nerve +intersection_of: RO:0000052 UBERON:0001643 ! inheres in oculomotor nerve +relationship: RO:0000052 UBERON:0001643 ! inheres in oculomotor nerve [Term] id: OBA:VT0001062 @@ -174009,7 +275160,7 @@ synonym: "size of oculomotor nerve" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001061 ! oculomotor nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001643 ! oculomotor nerve +intersection_of: RO:0000052 UBERON:0001643 ! inheres in oculomotor nerve [Term] id: OBA:VT0001063 @@ -174018,8 +275169,8 @@ def: "The morphology of a trochlear nerve." [AUTO:patterns/patterns/entity_attri synonym: "morphology of trochlear nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001644 ! trochlear nerve -relationship: inheres_in UBERON:0001644 ! trochlear nerve +intersection_of: RO:0000052 UBERON:0001644 ! inheres in trochlear nerve +relationship: RO:0000052 UBERON:0001644 ! inheres in trochlear nerve [Term] id: OBA:VT0001064 @@ -174029,7 +275180,7 @@ synonym: "size of trochlear nerve" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003316 ! nerve size is_a: OBA:VT0001063 ! trochlear nerve morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001644 ! trochlear nerve +intersection_of: RO:0000052 UBERON:0001644 ! inheres in trochlear nerve [Term] id: OBA:VT0001065 @@ -174039,7 +275190,7 @@ synonym: "morphology of trigeminal nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000321 ! trigeminal nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001645 ! trigeminal nerve +intersection_of: RO:0000052 UBERON:0001645 ! inheres in trigeminal nerve [Term] id: OBA:VT0001067 @@ -174049,8 +275200,8 @@ synonym: "morphology of mandibular nerve" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000375 ! mandibular nerve -relationship: inheres_in UBERON:0000375 ! mandibular nerve +intersection_of: RO:0000052 UBERON:0000375 ! inheres in mandibular nerve +relationship: RO:0000052 UBERON:0000375 ! inheres in mandibular nerve [Term] id: OBA:VT0001070 @@ -174060,7 +275211,7 @@ synonym: "morphology of abducens nerve" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000548 ! abducens nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001646 ! abducens nerve +intersection_of: RO:0000052 UBERON:0001646 ! inheres in abducens nerve [Term] id: OBA:VT0001071 @@ -174070,7 +275221,7 @@ synonym: "morphology of facial nerve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000245 ! facial nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001647 ! facial nerve +intersection_of: RO:0000052 UBERON:0001647 ! inheres in facial nerve [Term] id: OBA:VT0001072 @@ -174080,7 +275231,7 @@ synonym: "morphology of vestibulocochlear nerve" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000295 ! vestibulocochlear nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001648 ! vestibulocochlear nerve +intersection_of: RO:0000052 UBERON:0001648 ! inheres in vestibulocochlear nerve [Term] id: OBA:VT0001073 @@ -174090,7 +275241,7 @@ synonym: "morphology of glossopharyngeal nerve" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000319 ! glossopharyngeal nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001649 ! glossopharyngeal nerve +intersection_of: RO:0000052 UBERON:0001649 ! inheres in glossopharyngeal nerve [Term] id: OBA:VT0001074 @@ -174099,8 +275250,8 @@ def: "The morphology of a vagus nerve." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of vagus nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001759 ! vagus nerve -relationship: inheres_in UBERON:0001759 ! vagus nerve +intersection_of: RO:0000052 UBERON:0001759 ! inheres in vagus nerve +relationship: RO:0000052 UBERON:0001759 ! inheres in vagus nerve [Term] id: OBA:VT0001075 @@ -174110,7 +275261,7 @@ synonym: "morphology of accessory XI nerve" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000567 ! accessory XI nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002019 ! accessory XI nerve +intersection_of: RO:0000052 UBERON:0002019 ! inheres in accessory XI nerve [Term] id: OBA:VT0001076 @@ -174120,7 +275271,7 @@ synonym: "morphology of hypoglossal nerve" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000360 ! hypoglossal nerve quality is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001650 ! hypoglossal nerve +intersection_of: RO:0000052 UBERON:0001650 ! inheres in hypoglossal nerve [Term] id: OBA:VT0001077 @@ -174130,8 +275281,8 @@ synonym: "morphology of spinal nerve" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000471 ! nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001780 ! spinal nerve -relationship: inheres_in UBERON:0001780 ! spinal nerve +intersection_of: RO:0000052 UBERON:0001780 ! inheres in spinal nerve +relationship: RO:0000052 UBERON:0001780 ! inheres in spinal nerve [Term] id: OBA:VT0001078 @@ -174141,8 +275292,8 @@ synonym: "morphology of phrenic nerve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000471 ! nerve quality is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001884 ! phrenic nerve -relationship: inheres_in UBERON:0001884 ! phrenic nerve +intersection_of: RO:0000052 UBERON:0001884 ! inheres in phrenic nerve +relationship: RO:0000052 UBERON:0001884 ! inheres in phrenic nerve [Term] id: OBA:VT0001081 @@ -174152,7 +275303,7 @@ synonym: "morphology of cranial ganglion" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000203 ! cranial ganglion quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001714 ! cranial ganglion +intersection_of: RO:0000052 UBERON:0001714 ! inheres in cranial ganglion [Term] id: OBA:VT0001082 @@ -174162,8 +275313,8 @@ synonym: "morphology of geniculate ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000960 ! sensory ganglion morphology trait is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001700 ! geniculate ganglion -relationship: inheres_in UBERON:0001700 ! geniculate ganglion +intersection_of: RO:0000052 UBERON:0001700 ! inheres in geniculate ganglion +relationship: RO:0000052 UBERON:0001700 ! inheres in geniculate ganglion [Term] id: OBA:VT0001083 @@ -174173,7 +275324,7 @@ synonym: "size of geniculate ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001082 ! geniculate ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001700 ! geniculate ganglion +intersection_of: RO:0000052 UBERON:0001700 ! inheres in geniculate ganglion [Term] id: OBA:VT0001084 @@ -174182,8 +275333,8 @@ def: "The morphology of a inferior glossopharyngeal IX ganglion." [AUTO:patterns synonym: "morphology of inferior glossopharyngeal IX ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001096 ! glossopharyngeal ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005360 ! inferior glossopharyngeal IX ganglion -relationship: inheres_in UBERON:0005360 ! inferior glossopharyngeal IX ganglion +intersection_of: RO:0000052 UBERON:0005360 ! inheres in inferior glossopharyngeal IX ganglion +relationship: RO:0000052 UBERON:0005360 ! inheres in inferior glossopharyngeal IX ganglion [Term] id: OBA:VT0001085 @@ -174193,7 +275344,7 @@ synonym: "size of glossopharyngeal ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001096 ! glossopharyngeal ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001701 ! glossopharyngeal ganglion +intersection_of: RO:0000052 UBERON:0001701 ! inheres in glossopharyngeal ganglion [Term] id: OBA:VT0001087 @@ -174202,8 +275353,8 @@ def: "The morphology of a inferior vagus X ganglion." [AUTO:patterns/patterns/en synonym: "morphology of inferior vagus X ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001100 ! vagus ganglion morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005363 ! inferior vagus X ganglion -relationship: inheres_in UBERON:0005363 ! inferior vagus X ganglion +intersection_of: RO:0000052 UBERON:0005363 ! inheres in inferior vagus X ganglion +relationship: RO:0000052 UBERON:0005363 ! inheres in inferior vagus X ganglion [Term] id: OBA:VT0001088 @@ -174213,7 +275364,7 @@ synonym: "size of inferior vagus X ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001087 ! nodose ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005363 ! inferior vagus X ganglion +intersection_of: RO:0000052 UBERON:0005363 ! inheres in inferior vagus X ganglion [Term] id: OBA:VT0001092 @@ -174223,8 +275374,8 @@ synonym: "morphology of trigeminal ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000960 ! sensory ganglion morphology trait is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001675 ! trigeminal ganglion -relationship: inheres_in UBERON:0001675 ! trigeminal ganglion +intersection_of: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion +relationship: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion [Term] id: OBA:VT0001095 @@ -174234,7 +275385,7 @@ synonym: "size of trigeminal ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001092 ! trigeminal ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001675 ! trigeminal ganglion +intersection_of: RO:0000052 UBERON:0001675 ! inheres in trigeminal ganglion [Term] id: OBA:VT0001096 @@ -174243,8 +275394,8 @@ def: "The morphology of a glossopharyngeal ganglion." [AUTO:patterns/patterns/en synonym: "morphology of glossopharyngeal ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001701 ! glossopharyngeal ganglion -relationship: inheres_in UBERON:0001701 ! glossopharyngeal ganglion +intersection_of: RO:0000052 UBERON:0001701 ! inheres in glossopharyngeal ganglion +relationship: RO:0000052 UBERON:0001701 ! inheres in glossopharyngeal ganglion [Term] id: OBA:VT0001097 @@ -174253,8 +275404,8 @@ def: "The morphology of a superior glossopharyngeal IX ganglion." [AUTO:patterns synonym: "morphology of superior glossopharyngeal IX ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001096 ! glossopharyngeal ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005361 ! superior glossopharyngeal IX ganglion -relationship: inheres_in UBERON:0005361 ! superior glossopharyngeal IX ganglion +intersection_of: RO:0000052 UBERON:0005361 ! inheres in superior glossopharyngeal IX ganglion +relationship: RO:0000052 UBERON:0005361 ! inheres in superior glossopharyngeal IX ganglion [Term] id: OBA:VT0001098 @@ -174264,7 +275415,7 @@ synonym: "size of superior glossopharyngeal IX ganglion" EXACT [AUTO:patterns/pa is_a: OBA:VT0001085 ! petrosal ganglion size trait is_a: OBA:VT0001097 ! superior glossopharyngeal ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005361 ! superior glossopharyngeal IX ganglion +intersection_of: RO:0000052 UBERON:0005361 ! inheres in superior glossopharyngeal IX ganglion [Term] id: OBA:VT0001100 @@ -174273,8 +275424,8 @@ def: "The morphology of a vagus X ganglion." [AUTO:patterns/patterns/entity_attr synonym: "morphology of vagus X ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005362 ! vagus X ganglion -relationship: inheres_in UBERON:0005362 ! vagus X ganglion +intersection_of: RO:0000052 UBERON:0005362 ! inheres in vagus X ganglion +relationship: RO:0000052 UBERON:0005362 ! inheres in vagus X ganglion [Term] id: OBA:VT0001101 @@ -174283,8 +275434,8 @@ def: "The morphology of a superior vagus X ganglion." [AUTO:patterns/patterns/en synonym: "morphology of superior vagus X ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001100 ! vagus ganglion morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005364 ! superior vagus X ganglion -relationship: inheres_in UBERON:0005364 ! superior vagus X ganglion +intersection_of: RO:0000052 UBERON:0005364 ! inheres in superior vagus X ganglion +relationship: RO:0000052 UBERON:0005364 ! inheres in superior vagus X ganglion [Term] id: OBA:VT0001102 @@ -174294,7 +275445,7 @@ synonym: "size of superior vagus X ganglion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001101 ! superior vagus ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005364 ! superior vagus X ganglion +intersection_of: RO:0000052 UBERON:0005364 ! inheres in superior vagus X ganglion [Term] id: OBA:VT0001105 @@ -174311,7 +275462,7 @@ synonym: "morphology of myelinating Schwann cell" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000482 ! myelinating Schwann cell quality is_a: OBA:VT0001105 ! peripheral nervous system glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000218 ! myelinating Schwann cell +intersection_of: RO:0000052 CL:0000218 ! inheres in myelinating Schwann cell [Term] id: OBA:VT0001107 @@ -174321,7 +275472,7 @@ synonym: "has number of of myelinating Schwann cell" EXACT [AUTO:patterns/patter is_a: OBA:1000482 ! myelinating Schwann cell quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000218 ! myelinating Schwann cell +intersection_of: RO:0000052 CL:0000218 ! inheres in myelinating Schwann cell [Term] id: OBA:VT0001119 @@ -174331,7 +275482,7 @@ synonym: "morphology of female reproductive system" EXACT [AUTO:patterns/pattern is_a: OBA:1000213 ! female reproductive system quality is_a: OBA:VT0002160 ! reproductive system morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000474 ! female reproductive system +intersection_of: RO:0000052 UBERON:0000474 ! inheres in female reproductive system [Term] id: OBA:VT0001120 @@ -174341,8 +275492,8 @@ synonym: "morphology of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000995 ! uterus -relationship: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus +relationship: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:VT0001125 @@ -174351,8 +275502,8 @@ def: "The morphology of a oocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of oocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004240 ! female germ cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000023 ! oocyte -relationship: inheres_in CL:0000023 ! oocyte +intersection_of: RO:0000052 CL:0000023 ! inheres in oocyte +relationship: RO:0000052 CL:0000023 ! inheres in oocyte [Term] id: OBA:VT0001126 @@ -174362,7 +275513,7 @@ synonym: "morphology of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004650 ! female reproductive organ morphology is_a: OBA:1000545 ! ovary quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:VT0001127 @@ -174372,7 +275523,7 @@ synonym: "size of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002017 ! gonad size is_a: OBA:VT0001126 ! ovary morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:VT0001131 @@ -174382,7 +275533,7 @@ synonym: "morphology of ovarian follicle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000927 ! ovarian follicle quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001305 ! ovarian follicle +intersection_of: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle [Term] id: OBA:VT0001135 @@ -174392,7 +275543,7 @@ synonym: "morphology of uterine cervix" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000174 ! uterine cervix quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000002 ! uterine cervix +intersection_of: RO:0000052 UBERON:0000002 ! inheres in uterine cervix [Term] id: OBA:VT0001137 @@ -174402,8 +275553,8 @@ synonym: "morphology of cervix epithelium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004801 ! cervix epithelium -relationship: inheres_in UBERON:0004801 ! cervix epithelium +intersection_of: RO:0000052 UBERON:0004801 ! inheres in cervix epithelium +relationship: RO:0000052 UBERON:0004801 ! inheres in cervix epithelium [Term] id: OBA:VT0001138 @@ -174412,8 +275563,8 @@ def: "The morphology of a cervix squamous epithelium." [AUTO:patterns/patterns/e synonym: "morphology of cervix squamous epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001137 ! cervical epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006922 ! cervix squamous epithelium -relationship: inheres_in UBERON:0006922 ! cervix squamous epithelium +intersection_of: RO:0000052 UBERON:0006922 ! inheres in cervix squamous epithelium +relationship: RO:0000052 UBERON:0006922 ! inheres in cervix squamous epithelium [Term] id: OBA:VT0001139 @@ -174423,8 +275574,8 @@ synonym: "morphology of vagina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000996 ! vagina -relationship: inheres_in UBERON:0000996 ! vagina +intersection_of: RO:0000052 UBERON:0000996 ! inheres in vagina +relationship: RO:0000052 UBERON:0000996 ! inheres in vagina [Term] id: OBA:VT0001140 @@ -174434,8 +275585,8 @@ synonym: "morphology of epithelium of vagina" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001344 ! epithelium of vagina -relationship: inheres_in UBERON:0001344 ! epithelium of vagina +intersection_of: RO:0000052 UBERON:0001344 ! inheres in epithelium of vagina +relationship: RO:0000052 UBERON:0001344 ! inheres in epithelium of vagina [Term] id: OBA:VT0001141 @@ -174445,7 +275596,7 @@ synonym: "thickness of epithelium of vagina" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003602 ! epithelium of vagina size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001344 ! epithelium of vagina +intersection_of: RO:0000052 UBERON:0001344 ! inheres in epithelium of vagina [Term] id: OBA:VT0001142 @@ -174455,8 +275606,8 @@ synonym: "morphology of vagina orifice" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012317 ! vagina orifice -relationship: inheres_in UBERON:0012317 ! vagina orifice +intersection_of: RO:0000052 UBERON:0012317 ! inheres in vagina orifice +relationship: RO:0000052 UBERON:0012317 ! inheres in vagina orifice [Term] id: OBA:VT0001143 @@ -174466,7 +275617,7 @@ synonym: "size of vagina orifice" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001142 ! vaginal opening morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012317 ! vagina orifice +intersection_of: RO:0000052 UBERON:0012317 ! inheres in vagina orifice [Term] id: OBA:VT0001145 @@ -174476,7 +275627,7 @@ synonym: "morphology of male reproductive system" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000521 ! male reproductive system quality is_a: OBA:VT0002160 ! reproductive system morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000079 ! male reproductive system +intersection_of: RO:0000052 UBERON:0000079 ! inheres in male reproductive system [Term] id: OBA:VT0001146 @@ -174485,8 +275636,8 @@ def: "The morphology of a testis." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004643 ! male reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:VT0001148 @@ -174496,7 +275647,7 @@ synonym: "size of testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002017 ! gonad size is_a: OBA:VT0001146 ! testes morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:VT0001150 @@ -174506,7 +275657,7 @@ synonym: "size of scrotum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002669 ! scrotum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001300 ! scrotum +intersection_of: RO:0000052 UBERON:0001300 ! inheres in scrotum [Term] id: OBA:VT0001151 @@ -174516,7 +275667,7 @@ synonym: "size of prepuce of penis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003553 ! foreskin morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001332 ! prepuce of penis +intersection_of: RO:0000052 UBERON:0001332 ! inheres in prepuce of penis [Term] id: OBA:VT0001153 @@ -174526,7 +275677,7 @@ synonym: "size of seminiferous tubule of testis" EXACT [AUTO:patterns/patterns/e is_a: OBA:0000172 ! tube size is_a: OBA:VT0002216 ! seminiferous tubule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001343 ! seminiferous tubule of testis +intersection_of: RO:0000052 UBERON:0001343 ! inheres in seminiferous tubule of testis [Term] id: OBA:VT0001156 @@ -174535,8 +275686,8 @@ def: "The quality of a spermatogenesis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of spermatogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007283 ! spermatogenesis -relationship: inheres_in GO:0007283 ! spermatogenesis +intersection_of: RO:0000052 GO:0007283 ! inheres in spermatogenesis +relationship: RO:0000052 GO:0007283 ! inheres in spermatogenesis [Term] id: OBA:VT0001158 @@ -174545,8 +275696,8 @@ def: "The morphology of a prostate gland." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of prostate gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005813 ! male accessory sex gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002367 ! prostate gland -relationship: inheres_in UBERON:0002367 ! prostate gland +intersection_of: RO:0000052 UBERON:0002367 ! inheres in prostate gland +relationship: RO:0000052 UBERON:0002367 ! inheres in prostate gland [Term] id: OBA:VT0001163 @@ -174555,8 +275706,8 @@ def: "The morphology of a coagulating gland." [AUTO:patterns/patterns/entity_att synonym: "morphology of coagulating gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005813 ! male accessory sex gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008807 ! coagulating gland -relationship: inheres_in UBERON:0008807 ! coagulating gland +intersection_of: RO:0000052 UBERON:0008807 ! inheres in coagulating gland +relationship: RO:0000052 UBERON:0008807 ! inheres in coagulating gland [Term] id: OBA:VT0001168 @@ -174566,8 +275717,8 @@ synonym: "morphology of prostate epithelium" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000428 ! prostate epithelium -relationship: inheres_in UBERON:0000428 ! prostate epithelium +intersection_of: RO:0000052 UBERON:0000428 ! inheres in prostate epithelium +relationship: RO:0000052 UBERON:0000428 ! inheres in prostate epithelium [Term] id: OBA:VT0001169 @@ -174577,8 +275728,8 @@ synonym: "morphology of bulbo-urethral gland" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0005560 ! male urethral gland morphology is_a: OBA:0005813 ! male accessory sex gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002366 ! bulbo-urethral gland -relationship: inheres_in UBERON:0002366 ! bulbo-urethral gland +intersection_of: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland +relationship: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland [Term] id: OBA:VT0001170 @@ -174588,7 +275739,7 @@ synonym: "size of bulbo-urethral gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0001169 ! bulbourethral gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002366 ! bulbo-urethral gland +intersection_of: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland [Term] id: OBA:VT0001175 @@ -174598,8 +275749,8 @@ synonym: "morphology of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002048 ! lung -relationship: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung +relationship: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:VT0001176 @@ -174608,8 +275759,8 @@ def: "The quality of a lung development." [AUTO:patterns/patterns/entity_attribu synonym: "quality of lung development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030324 ! lung development -relationship: inheres_in GO:0030324 ! lung development +intersection_of: RO:0000052 GO:0030324 ! inheres in lung development +relationship: RO:0000052 GO:0030324 ! inheres in lung development [Term] id: OBA:VT0001179 @@ -174619,7 +275770,7 @@ synonym: "thickness of interalveolar septum" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003610 ! interalveolar septum size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0004893 ! interalveolar septum +intersection_of: RO:0000052 UBERON:0004893 ! inheres in interalveolar septum [Term] id: OBA:VT0001183 @@ -174629,7 +275780,7 @@ synonym: "size of alveolus of lung" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002270 ! respiratory alveoli morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002299 ! alveolus of lung +intersection_of: RO:0000052 UBERON:0002299 ! inheres in alveolus of lung [Term] id: OBA:VT0001200 @@ -174639,7 +275790,7 @@ synonym: "thickness of zone of skin" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003618 ! zone of skin size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:VT0001216 @@ -174648,8 +275799,8 @@ def: "The morphology of a skin epidermis." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of skin epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001003 ! skin epidermis -relationship: inheres_in UBERON:0001003 ! skin epidermis +intersection_of: RO:0000052 UBERON:0001003 ! inheres in skin epidermis +relationship: RO:0000052 UBERON:0001003 ! inheres in skin epidermis [Term] id: OBA:VT0001219 @@ -174659,7 +275810,7 @@ synonym: "thickness of skin epidermis" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0002167 ! skin epidermis size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001003 ! skin epidermis +intersection_of: RO:0000052 UBERON:0001003 ! inheres in skin epidermis [Term] id: OBA:VT0001225 @@ -174668,8 +275819,8 @@ def: "The quality of a epidermis development." [AUTO:patterns/patterns/entity_at synonym: "quality of epidermis development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008544 ! epidermis development -relationship: inheres_in GO:0008544 ! epidermis development +intersection_of: RO:0000052 GO:0008544 ! inheres in epidermis development +relationship: RO:0000052 GO:0008544 ! inheres in epidermis development [Term] id: OBA:VT0001231 @@ -174678,8 +275829,8 @@ def: "The morphology of a stratum basale of epidermis." [AUTO:patterns/patterns/ synonym: "morphology of stratum basale of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002025 ! stratum basale of epidermis -relationship: inheres_in UBERON:0002025 ! stratum basale of epidermis +intersection_of: RO:0000052 UBERON:0002025 ! inheres in stratum basale of epidermis +relationship: RO:0000052 UBERON:0002025 ! inheres in stratum basale of epidermis [Term] id: OBA:VT0001236 @@ -174688,8 +275839,8 @@ def: "The morphology of a stratum spinosum of epidermis." [AUTO:patterns/pattern synonym: "morphology of stratum spinosum of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002026 ! stratum spinosum of epidermis -relationship: inheres_in UBERON:0002026 ! stratum spinosum of epidermis +intersection_of: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis +relationship: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis [Term] id: OBA:VT0001237 @@ -174699,8 +275850,8 @@ synonym: "size of prickle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0002655 ! keratinocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000649 ! prickle cell -relationship: inheres_in CL:0000649 ! prickle cell +intersection_of: RO:0000052 CL:0000649 ! inheres in prickle cell +relationship: RO:0000052 CL:0000649 ! inheres in prickle cell [Term] id: OBA:VT0001238 @@ -174710,7 +275861,7 @@ synonym: "thickness of stratum spinosum of epidermis" EXACT [AUTO:patterns/patte is_a: OBA:0003624 ! stratum spinosum of epidermis size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002026 ! stratum spinosum of epidermis +intersection_of: RO:0000052 UBERON:0002026 ! inheres in stratum spinosum of epidermis [Term] id: OBA:VT0001239 @@ -174719,8 +275870,8 @@ def: "The morphology of a stratum granulosum of epidermis." [AUTO:patterns/patte synonym: "morphology of stratum granulosum of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002069 ! stratum granulosum of epidermis -relationship: inheres_in UBERON:0002069 ! stratum granulosum of epidermis +intersection_of: RO:0000052 UBERON:0002069 ! inheres in stratum granulosum of epidermis +relationship: RO:0000052 UBERON:0002069 ! inheres in stratum granulosum of epidermis [Term] id: OBA:VT0001240 @@ -174730,8 +275881,8 @@ synonym: "morphology of stratum corneum of epidermis" EXACT [AUTO:patterns/patte is_a: OBA:0005850 ! periderm morphology is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002027 ! stratum corneum of epidermis -relationship: inheres_in UBERON:0002027 ! stratum corneum of epidermis +intersection_of: RO:0000052 UBERON:0002027 ! inheres in stratum corneum of epidermis +relationship: RO:0000052 UBERON:0002027 ! inheres in stratum corneum of epidermis [Term] id: OBA:VT0001242 @@ -174741,7 +275892,7 @@ synonym: "thickness of stratum corneum of epidermis" EXACT [AUTO:patterns/patter is_a: OBA:0002778 ! stratum corneum of epidermis size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002027 ! stratum corneum of epidermis +intersection_of: RO:0000052 UBERON:0002027 ! inheres in stratum corneum of epidermis [Term] id: OBA:VT0001243 @@ -174750,8 +275901,8 @@ def: "The morphology of a dermis." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of dermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002067 ! dermis -relationship: inheres_in UBERON:0002067 ! dermis +intersection_of: RO:0000052 UBERON:0002067 ! inheres in dermis +relationship: RO:0000052 UBERON:0002067 ! inheres in dermis [Term] id: OBA:VT0001245 @@ -174761,7 +275912,7 @@ synonym: "thickness of dermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003625 ! dermis size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002067 ! dermis +intersection_of: RO:0000052 UBERON:0002067 ! inheres in dermis [Term] id: OBA:VT0001248 @@ -174771,7 +275922,7 @@ synonym: "morphology of connective tissue" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002384 ! connective tissue +intersection_of: RO:0000052 UBERON:0002384 ! inheres in connective tissue [Term] id: OBA:VT0001250 @@ -174781,7 +275932,7 @@ synonym: "morphology of papillary layer of dermis" EXACT [AUTO:patterns/patterns is_a: OBA:1000908 ! papillary layer of dermis quality is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001992 ! papillary layer of dermis +intersection_of: RO:0000052 UBERON:0001992 ! inheres in papillary layer of dermis [Term] id: OBA:VT0001253 @@ -174791,7 +275942,7 @@ synonym: "height of multicellular organism" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0100005 ! body size trait is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0001256 @@ -174801,7 +275952,7 @@ synonym: "length of multicellular organism" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0100005 ! body size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0001259 @@ -174811,7 +275962,7 @@ synonym: "mass of multicellular organism" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0001274 @@ -174821,7 +275972,7 @@ synonym: "shape of strand of vibrissa hair" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003493 ! strand of hair shape is_a: OBA:VT0002098 ! vibrissa morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0006378 ! strand of vibrissa hair +intersection_of: RO:0000052 UBERON:0006378 ! inheres in strand of vibrissa hair [Term] id: OBA:VT0001277 @@ -174831,7 +275982,7 @@ synonym: "spatial pattern of strand of vibrissa hair" EXACT [AUTO:patterns/patte is_a: OBA:0002806 ! strand of hair spatial pattern is_a: OBA:VT0002098 ! vibrissa morphology trait intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in UBERON:0006378 ! strand of vibrissa hair +intersection_of: RO:0000052 UBERON:0006378 ! inheres in strand of vibrissa hair [Term] id: OBA:VT0001281 @@ -174841,7 +275992,7 @@ synonym: "length of strand of vibrissa hair" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0000417 ! hair length is_a: OBA:VT0002098 ! vibrissa morphology trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006378 ! strand of vibrissa hair +intersection_of: RO:0000052 UBERON:0006378 ! inheres in strand of vibrissa hair [Term] id: OBA:VT0001286 @@ -174850,8 +276001,8 @@ def: "The quality of a eye development." [AUTO:patterns/patterns/entity_attribut synonym: "quality of eye development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001654 ! eye development -relationship: inheres_in GO:0001654 ! eye development +intersection_of: RO:0000052 GO:0001654 ! inheres in eye development +relationship: RO:0000052 GO:0001654 ! inheres in eye development [Term] id: OBA:VT0001299 @@ -174861,7 +276012,7 @@ synonym: "orientation of camera-type eye" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003631 ! camera-type eye position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:VT0001303 @@ -174871,7 +276022,7 @@ synonym: "morphology of lens of camera-type eye" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000227 ! lens of camera-type eye quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:VT0001305 @@ -174881,7 +276032,7 @@ synonym: "size of lens of camera-type eye" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001303 ! lens morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:VT0001308 @@ -174891,7 +276042,7 @@ synonym: "polarity of lens of camera-type eye" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000227 ! lens of camera-type eye quality is_a: PATO:0002186 ! polarity intersection_of: PATO:0002186 ! polarity -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:VT0001310 @@ -174901,7 +276052,7 @@ synonym: "morphology of conjunctiva" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000477 ! conjunctiva quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001811 ! conjunctiva +intersection_of: RO:0000052 UBERON:0001811 ! inheres in conjunctiva [Term] id: OBA:VT0001312 @@ -174911,7 +276062,7 @@ synonym: "morphology of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000536 ! cornea quality is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:VT0001317 @@ -174921,7 +276072,7 @@ synonym: "morphology of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000396 ! pupil quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:VT0001319 @@ -174931,7 +276082,7 @@ synonym: "shape of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001317 ! pupil morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:VT0001321 @@ -174941,7 +276092,7 @@ synonym: "size of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001317 ! pupil morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:VT0001322 @@ -174951,7 +276102,7 @@ synonym: "morphology of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000385 ! iris quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris [Term] id: OBA:VT0001324 @@ -174960,8 +276111,8 @@ def: "The quality of a eye pigmentation." [AUTO:patterns/patterns/entity_attribu synonym: "quality of eye pigmentation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048069 ! eye pigmentation -relationship: inheres_in GO:0048069 ! eye pigmentation +intersection_of: RO:0000052 GO:0048069 ! inheres in eye pigmentation +relationship: RO:0000052 GO:0048069 ! inheres in eye pigmentation [Term] id: OBA:VT0001325 @@ -174971,8 +276122,8 @@ synonym: "morphology of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000966 ! retina -relationship: inheres_in UBERON:0000966 ! retina +intersection_of: RO:0000052 UBERON:0000966 ! inheres in retina +relationship: RO:0000052 UBERON:0000966 ! inheres in retina [Term] id: OBA:VT0001329 @@ -174982,8 +276133,8 @@ synonym: "amount of retinal cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0009004 ! retinal cell -relationship: inheres_in CL:0009004 ! retinal cell +intersection_of: RO:0000052 CL:0009004 ! inheres in retinal cell +relationship: RO:0000052 CL:0009004 ! inheres in retinal cell [Term] id: OBA:VT0001330 @@ -174993,8 +276144,8 @@ synonym: "morphology of neuron projection bundle connecting eye with brain" EXAC is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004904 ! neuron projection bundle connecting eye with brain -relationship: inheres_in UBERON:0004904 ! neuron projection bundle connecting eye with brain +intersection_of: RO:0000052 UBERON:0004904 ! inheres in neuron projection bundle connecting eye with brain +relationship: RO:0000052 UBERON:0004904 ! inheres in neuron projection bundle connecting eye with brain [Term] id: OBA:VT0001334 @@ -175004,7 +276155,7 @@ synonym: "size of optic tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004267 ! optic tract morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001908 ! optic tract +intersection_of: RO:0000052 UBERON:0001908 ! inheres in optic tract [Term] id: OBA:VT0001340 @@ -175014,8 +276165,8 @@ synonym: "morphology of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001711 ! eyelid -relationship: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid +relationship: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:VT0001345 @@ -175025,7 +276176,7 @@ synonym: "size of tarsal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000652 ! sebaceous gland size trait is_a: OBA:VT0005252 ! meibomian gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001818 ! tarsal gland +intersection_of: RO:0000052 UBERON:0001818 ! inheres in tarsal gland [Term] id: OBA:VT0001346 @@ -175035,7 +276186,7 @@ synonym: "morphology of lacrimal gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0005862 ! exocrine gland morphology is_a: OBA:1000437 ! lacrimal gland quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001817 ! lacrimal gland +intersection_of: RO:0000052 UBERON:0001817 ! inheres in lacrimal gland [Term] id: OBA:VT0001348 @@ -175045,7 +276196,7 @@ synonym: "functionality of lacrimal gland" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005863 ! exocrine gland functionality is_a: OBA:1000437 ! lacrimal gland quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001817 ! lacrimal gland +intersection_of: RO:0000052 UBERON:0001817 ! inheres in lacrimal gland [Term] id: OBA:VT0001365 @@ -175054,8 +276205,8 @@ def: "The amount of a Deiter's cell." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of Deiter's cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003947 ! organ of Corti supporting cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000635 ! Deiter's cell -relationship: inheres_in CL:0000635 ! Deiter's cell +intersection_of: RO:0000052 CL:0000635 ! inheres in Deiter's cell +relationship: RO:0000052 CL:0000635 ! inheres in Deiter's cell [Term] id: OBA:VT0001366 @@ -175065,8 +276216,8 @@ synonym: "has number of of pillar cell" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:1000191 ! pillar cell -relationship: inheres_in CL:1000191 ! pillar cell +intersection_of: RO:0000052 CL:1000191 ! inheres in pillar cell +relationship: RO:0000052 CL:1000191 ! inheres in pillar cell [Term] id: OBA:VT0001387 @@ -175076,7 +276227,7 @@ synonym: "size of spiral ligament" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004288 ! spiral ligament morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006725 ! spiral ligament +intersection_of: RO:0000052 UBERON:0006725 ! inheres in spiral ligament [Term] id: OBA:VT0001416 @@ -175086,8 +276237,8 @@ synonym: "amount of strial marginal cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002492 ! strial marginal cell -relationship: inheres_in CL:0002492 ! strial marginal cell +intersection_of: RO:0000052 CL:0002492 ! inheres in strial marginal cell +relationship: RO:0000052 CL:0002492 ! inheres in strial marginal cell [Term] id: OBA:VT0001418 @@ -175097,7 +276248,7 @@ synonym: "size of tectorial membrane of cochlea" EXACT [AUTO:patterns/patterns/e is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003149 ! tectorial membrane morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002233 ! tectorial membrane of cochlea +intersection_of: RO:0000052 UBERON:0002233 ! inheres in tectorial membrane of cochlea [Term] id: OBA:VT0001421 @@ -175107,7 +276258,7 @@ synonym: "size of scala media" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0003169 ! scala media morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002295 ! scala media +intersection_of: RO:0000052 UBERON:0002295 ! inheres in scala media [Term] id: OBA:VT0001422 @@ -175116,8 +276267,8 @@ def: "The quality of a drinking behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of drinking behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042756 ! drinking behavior -relationship: inheres_in GO:0042756 ! drinking behavior +intersection_of: RO:0000052 GO:0042756 ! inheres in drinking behavior +relationship: RO:0000052 GO:0042756 ! inheres in drinking behavior [Term] id: OBA:VT0001431 @@ -175126,8 +276277,8 @@ def: "The quality of a eating behavior." [AUTO:patterns/patterns/entity_attribut synonym: "quality of eating behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042755 ! eating behavior -relationship: inheres_in GO:0042755 ! eating behavior +intersection_of: RO:0000052 GO:0042755 ! inheres in eating behavior +relationship: RO:0000052 GO:0042755 ! inheres in eating behavior [Term] id: OBA:VT0001440 @@ -175136,8 +276287,8 @@ def: "The quality of a grooming behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of grooming behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007625 ! grooming behavior -relationship: inheres_in GO:0007625 ! grooming behavior +intersection_of: RO:0000052 GO:0007625 ! inheres in grooming behavior +relationship: RO:0000052 GO:0007625 ! inheres in grooming behavior [Term] id: OBA:VT0001444 @@ -175147,7 +276298,7 @@ synonym: "size of scala tympani" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0003167 ! scala tympani morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001864 ! scala tympani +intersection_of: RO:0000052 UBERON:0001864 ! inheres in scala tympani [Term] id: OBA:VT0001456 @@ -175157,7 +276308,7 @@ synonym: "size of otic capsule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000039 ! otic capsule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004637 ! otic capsule +intersection_of: RO:0000052 UBERON:0004637 ! inheres in otic capsule [Term] id: OBA:VT0001457 @@ -175166,8 +276317,8 @@ def: "The morphology of a vestibular dark cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of vestibular dark cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000846 ! vestibular dark cell -relationship: inheres_in CL:0000846 ! vestibular dark cell +intersection_of: RO:0000052 CL:0000846 ! inheres in vestibular dark cell +relationship: RO:0000052 CL:0000846 ! inheres in vestibular dark cell [Term] id: OBA:VT0001459 @@ -175177,7 +276328,7 @@ synonym: "size of externally connecting tube lumen" EXACT [AUTO:patterns/pattern is_a: OBA:VT0000034 ! vestibule morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001349 ! externally connecting tube lumen +intersection_of: RO:0000052 UBERON:0001349 ! inheres in externally connecting tube lumen [Term] id: OBA:VT0001464 @@ -175187,7 +276338,7 @@ synonym: "size of incus bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003739 ! auditory ossicle size trait is_a: OBA:VT0005106 ! incus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001688 ! incus bone +intersection_of: RO:0000052 UBERON:0001688 ! inheres in incus bone [Term] id: OBA:VT0001465 @@ -175197,7 +276348,7 @@ synonym: "size of malleus bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000029 ! malleus morphology trait is_a: OBA:VT0003739 ! auditory ossicle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001689 ! malleus bone +intersection_of: RO:0000052 UBERON:0001689 ! inheres in malleus bone [Term] id: OBA:VT0001501 @@ -175207,8 +276358,8 @@ synonym: "spatial pattern of sleep" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in GO:0030431 ! sleep -relationship: inheres_in GO:0030431 ! sleep +intersection_of: RO:0000052 GO:0030431 ! inheres in sleep +relationship: RO:0000052 GO:0030431 ! inheres in sleep [Term] id: OBA:VT0001525 @@ -175218,7 +276369,7 @@ synonym: "balance of multicellular organism" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000185 ! balance intersection_of: PATO:0000185 ! balance -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0001529 @@ -175227,8 +276378,8 @@ def: "The quality of a vocalization behavior." [AUTO:patterns/patterns/entity_at synonym: "quality of vocalization behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0071625 ! vocalization behavior -relationship: inheres_in GO:0071625 ! vocalization behavior +intersection_of: RO:0000052 GO:0071625 ! inheres in vocalization behavior +relationship: RO:0000052 GO:0071625 ! inheres in vocalization behavior [Term] id: OBA:VT0001539 @@ -175237,8 +276388,8 @@ def: "The has number of of a caudal vertebra." [AUTO:patterns/patterns/entity_at synonym: "has number of of caudal vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000138 ! vertebra quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001095 ! caudal vertebra -relationship: inheres_in UBERON:0001095 ! caudal vertebra +intersection_of: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra +relationship: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra [Term] id: OBA:VT0001541 @@ -175248,8 +276399,8 @@ synonym: "functionality of osteoclast" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0002442 ! leukocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000092 ! osteoclast -relationship: inheres_in CL:0000092 ! osteoclast +intersection_of: RO:0000052 CL:0000092 ! inheres in osteoclast +relationship: RO:0000052 CL:0000092 ! inheres in osteoclast [Term] id: OBA:VT0001542 @@ -175259,8 +276410,8 @@ synonym: "strength of bone element" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001230 ! strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:VT0001544 @@ -175270,8 +276421,8 @@ synonym: "functionality of cardiovascular system" EXACT [AUTO:patterns/patterns/ is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004535 ! cardiovascular system -relationship: inheres_in UBERON:0004535 ! cardiovascular system +intersection_of: RO:0000052 UBERON:0004535 ! inheres in cardiovascular system +relationship: RO:0000052 UBERON:0004535 ! inheres in cardiovascular system [Term] id: OBA:VT0001547 @@ -175281,8 +276432,8 @@ synonym: "amount of lipid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:18059 ! lipid -relationship: inheres_in CHEBI:18059 ! lipid +intersection_of: RO:0000052 CHEBI:18059 ! inheres in lipid +relationship: RO:0000052 CHEBI:18059 ! inheres in lipid [Term] id: OBA:VT0001560 @@ -175322,8 +276473,8 @@ synonym: "amount of erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000866 ! blood cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000232 ! erythrocyte -relationship: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte +relationship: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:VT0001588 @@ -175332,8 +276483,8 @@ def: "The amount of a hemoglobin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of hemoglobin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010120 ! protein amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:35143 ! hemoglobin -relationship: inheres_in CHEBI:35143 ! hemoglobin +intersection_of: RO:0000052 CHEBI:35143 ! inheres in hemoglobin +relationship: RO:0000052 CHEBI:35143 ! inheres in hemoglobin [Term] id: OBA:VT0001601 @@ -175342,8 +276493,8 @@ def: "The quality of a myeloid cell development." [AUTO:patterns/patterns/entity synonym: "quality of myeloid cell development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061515 ! myeloid cell development -relationship: inheres_in GO:0061515 ! myeloid cell development +intersection_of: RO:0000052 GO:0061515 ! inheres in myeloid cell development +relationship: RO:0000052 GO:0061515 ! inheres in myeloid cell development [Term] id: OBA:VT0001614 @@ -175353,8 +276504,8 @@ synonym: "morphology of blood vessel" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001981 ! blood vessel -relationship: inheres_in UBERON:0001981 ! blood vessel +intersection_of: RO:0000052 UBERON:0001981 ! inheres in blood vessel +relationship: RO:0000052 UBERON:0001981 ! inheres in blood vessel [Term] id: OBA:VT0001649 @@ -175364,7 +276515,7 @@ synonym: "morphology of mandibular symphysis" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003754 ! skeletal joint morphology is_a: OBA:1000916 ! mandibular symphysis quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006606 ! mandibular symphysis +intersection_of: RO:0000052 UBERON:0006606 ! inheres in mandibular symphysis [Term] id: OBA:VT0001663 @@ -175374,7 +276525,7 @@ synonym: "functionality of digestive system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT1000776 ! alimentary system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001007 ! digestive system +intersection_of: RO:0000052 UBERON:0001007 ! inheres in digestive system [Term] id: OBA:VT0001664 @@ -175383,8 +276534,8 @@ def: "The quality of a digestion." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of digestion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007586 ! digestion -relationship: inheres_in GO:0007586 ! digestion +intersection_of: RO:0000052 GO:0007586 ! inheres in digestion +relationship: RO:0000052 GO:0007586 ! inheres in digestion [Term] id: OBA:VT0001675 @@ -175393,8 +276544,8 @@ def: "The quality of a ectoderm development." [AUTO:patterns/patterns/entity_att synonym: "quality of ectoderm development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007398 ! ectoderm development -relationship: inheres_in GO:0007398 ! ectoderm development +intersection_of: RO:0000052 GO:0007398 ! inheres in ectoderm development +relationship: RO:0000052 GO:0007398 ! inheres in ectoderm development [Term] id: OBA:VT0001680 @@ -175403,8 +276554,8 @@ def: "The quality of a mesoderm development." [AUTO:patterns/patterns/entity_att synonym: "quality of mesoderm development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007498 ! mesoderm development -relationship: inheres_in GO:0007498 ! mesoderm development +intersection_of: RO:0000052 GO:0007498 ! inheres in mesoderm development +relationship: RO:0000052 GO:0007498 ! inheres in mesoderm development [Term] id: OBA:VT0001684 @@ -175414,7 +276565,7 @@ synonym: "axial to of mesoderm development" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0001680 ! mesoderm development trait is_a: PATO:0002036 ! axial to intersection_of: PATO:0002036 ! axial to -intersection_of: inheres_in GO:0007498 ! mesoderm development +intersection_of: RO:0000052 GO:0007498 ! inheres in mesoderm development [Term] id: OBA:VT0001685 @@ -175423,8 +276574,8 @@ def: "The quality of a endoderm development." [AUTO:patterns/patterns/entity_att synonym: "quality of endoderm development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007492 ! endoderm development -relationship: inheres_in GO:0007492 ! endoderm development +intersection_of: RO:0000052 GO:0007492 ! inheres in endoderm development +relationship: RO:0000052 GO:0007492 ! inheres in endoderm development [Term] id: OBA:VT0001688 @@ -175433,8 +276584,8 @@ def: "The quality of a somite development." [AUTO:patterns/patterns/entity_attri synonym: "quality of somite development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061053 ! somite development -relationship: inheres_in GO:0061053 ! somite development +intersection_of: RO:0000052 GO:0061053 ! inheres in somite development +relationship: RO:0000052 GO:0061053 ! inheres in somite development [Term] id: OBA:VT0001691 @@ -175444,7 +276595,7 @@ synonym: "shape of somite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010122 ! somite morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002329 ! somite +intersection_of: RO:0000052 UBERON:0002329 ! inheres in somite [Term] id: OBA:VT0001695 @@ -175453,8 +276604,8 @@ def: "The quality of a gastrulation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of gastrulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007369 ! gastrulation -relationship: inheres_in GO:0007369 ! gastrulation +intersection_of: RO:0000052 GO:0007369 ! inheres in gastrulation +relationship: RO:0000052 GO:0007369 ! inheres in gastrulation [Term] id: OBA:VT0001697 @@ -175464,7 +276615,7 @@ synonym: "size of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001076 ! embryo morphology is_a: OBA:VT0100005 ! body size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:VT0001710 @@ -175473,8 +276624,8 @@ def: "The morphology of a amniotic fold." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of amniotic fold" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005971 ! amniotic fold -relationship: inheres_in UBERON:0005971 ! amniotic fold +intersection_of: RO:0000052 UBERON:0005971 ! inheres in amniotic fold +relationship: RO:0000052 UBERON:0005971 ! inheres in amniotic fold [Term] id: OBA:VT0001711 @@ -175484,7 +276635,7 @@ synonym: "morphology of placenta" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000620 ! placenta quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:VT0001712 @@ -175493,8 +276644,8 @@ def: "The quality of a placenta development." [AUTO:patterns/patterns/entity_att synonym: "quality of placenta development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001890 ! placenta development -relationship: inheres_in GO:0001890 ! placenta development +intersection_of: RO:0000052 GO:0001890 ! inheres in placenta development +relationship: RO:0000052 GO:0001890 ! inheres in placenta development [Term] id: OBA:VT0001716 @@ -175504,8 +276655,8 @@ synonym: "morphology of placenta labyrinth" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003946 ! placenta labyrinth -relationship: inheres_in UBERON:0003946 ! placenta labyrinth +intersection_of: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth +relationship: RO:0000052 UBERON:0003946 ! inheres in placenta labyrinth [Term] id: OBA:VT0001718 @@ -175515,8 +276666,8 @@ synonym: "morphology of yolk sac" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001040 ! yolk sac -relationship: inheres_in UBERON:0001040 ! yolk sac +intersection_of: RO:0000052 UBERON:0001040 ! inheres in yolk sac +relationship: RO:0000052 UBERON:0001040 ! inheres in yolk sac [Term] id: OBA:VT0001721 @@ -175526,8 +276677,8 @@ synonym: "morphology of blood island" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003061 ! blood island -relationship: inheres_in UBERON:0003061 ! blood island +intersection_of: RO:0000052 UBERON:0003061 ! inheres in blood island +relationship: RO:0000052 UBERON:0003061 ! inheres in blood island [Term] id: OBA:VT0001722 @@ -175537,7 +276688,7 @@ synonym: "color of yolk sac" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001718 ! yolk sac morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001040 ! yolk sac +intersection_of: RO:0000052 UBERON:0001040 ! inheres in yolk sac [Term] id: OBA:VT0001724 @@ -175547,8 +276698,8 @@ synonym: "morphology of visceral endoderm" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004877 ! visceral endoderm -relationship: inheres_in UBERON:0004877 ! visceral endoderm +intersection_of: RO:0000052 UBERON:0004877 ! inheres in visceral endoderm +relationship: RO:0000052 UBERON:0004877 ! inheres in visceral endoderm [Term] id: OBA:VT0001725 @@ -175558,7 +276709,7 @@ synonym: "morphology of umbilical cord" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000626 ! umbilical cord quality is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002331 ! umbilical cord +intersection_of: RO:0000052 UBERON:0002331 ! inheres in umbilical cord [Term] id: OBA:VT0001726 @@ -175568,8 +276719,8 @@ synonym: "morphology of allantois" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004340 ! allantois -relationship: inheres_in UBERON:0004340 ! allantois +intersection_of: RO:0000052 UBERON:0004340 ! inheres in allantois +relationship: RO:0000052 UBERON:0004340 ! inheres in allantois [Term] id: OBA:VT0001727 @@ -175578,8 +276729,8 @@ def: "The quality of a embryo implantation." [AUTO:patterns/patterns/entity_attr synonym: "quality of embryo implantation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007566 ! embryo implantation -relationship: inheres_in GO:0007566 ! embryo implantation +intersection_of: RO:0000052 GO:0007566 ! inheres in embryo implantation +relationship: RO:0000052 GO:0007566 ! inheres in embryo implantation [Term] id: OBA:VT0001740 @@ -175588,8 +276739,8 @@ def: "The quality of a epinephrine secretion." [AUTO:patterns/patterns/entity_at synonym: "quality of epinephrine secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048242 ! epinephrine secretion -relationship: inheres_in GO:0048242 ! epinephrine secretion +intersection_of: RO:0000052 GO:0048242 ! inheres in epinephrine secretion +relationship: RO:0000052 GO:0048242 ! inheres in epinephrine secretion [Term] id: OBA:VT0001744 @@ -175598,8 +276749,8 @@ def: "The quality of a corticosterone secretion." [AUTO:patterns/patterns/entity synonym: "quality of corticosterone secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0035934 ! corticosterone secretion -relationship: inheres_in GO:0035934 ! corticosterone secretion +intersection_of: RO:0000052 GO:0035934 ! inheres in corticosterone secretion +relationship: RO:0000052 GO:0035934 ! inheres in corticosterone secretion [Term] id: OBA:VT0001754 @@ -175625,8 +276776,8 @@ def: "The quality of a homeostatic process." [AUTO:patterns/patterns/entity_attr synonym: "quality of homeostatic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042592 ! homeostatic process -relationship: inheres_in GO:0042592 ! homeostatic process +intersection_of: RO:0000052 GO:0042592 ! inheres in homeostatic process +relationship: RO:0000052 GO:0042592 ! inheres in homeostatic process [Term] id: OBA:VT0001765 @@ -175635,8 +276786,8 @@ def: "The quality of a ion homeostasis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of ion homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050801 ! ion homeostasis -relationship: inheres_in GO:0050801 ! ion homeostasis +intersection_of: RO:0000052 GO:0050801 ! inheres in ion homeostasis +relationship: RO:0000052 GO:0050801 ! inheres in ion homeostasis [Term] id: OBA:VT0001770 @@ -175645,8 +276796,8 @@ def: "The amount of a iron atom." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of iron atom" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000182 ! nutrient level intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:18248 ! iron atom -relationship: inheres_in CHEBI:18248 ! iron atom +intersection_of: RO:0000052 CHEBI:18248 ! inheres in iron atom +relationship: RO:0000052 CHEBI:18248 ! inheres in iron atom [Term] id: OBA:VT0001771 @@ -175662,8 +276813,8 @@ def: "The amount of a selenium atom." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of selenium atom" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000182 ! nutrient level intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:27568 ! selenium atom -relationship: inheres_in CHEBI:27568 ! selenium atom +intersection_of: RO:0000052 CHEBI:27568 ! inheres in selenium atom +relationship: RO:0000052 CHEBI:27568 ! inheres in selenium atom [Term] id: OBA:VT0001776 @@ -175679,8 +276830,8 @@ def: "The amount of a brown adipose tissue." [AUTO:patterns/patterns/entity_attr synonym: "amount of brown adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005452 ! adipose amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001348 ! brown adipose tissue -relationship: inheres_in UBERON:0001348 ! brown adipose tissue +intersection_of: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue +relationship: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue [Term] id: OBA:VT0001781 @@ -175689,8 +276840,8 @@ def: "The amount of a white adipose tissue." [AUTO:patterns/patterns/entity_attr synonym: "amount of white adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005452 ! adipose amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001347 ! white adipose tissue -relationship: inheres_in UBERON:0001347 ! white adipose tissue +intersection_of: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue +relationship: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue [Term] id: OBA:VT0001784 @@ -175699,8 +276850,8 @@ def: "The quality of a regulation of body fluid levels." [AUTO:patterns/patterns synonym: "quality of regulation of body fluid levels" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050878 ! regulation of body fluid levels -relationship: inheres_in GO:0050878 ! regulation of body fluid levels +intersection_of: RO:0000052 GO:0050878 ! inheres in regulation of body fluid levels +relationship: RO:0000052 GO:0050878 ! inheres in regulation of body fluid levels [Term] id: OBA:VT0001790 @@ -175710,7 +276861,7 @@ synonym: "functionality of immune system" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT1000783 ! immune system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002405 ! immune system +intersection_of: RO:0000052 UBERON:0002405 ! inheres in immune system [Term] id: OBA:VT0001830 @@ -175719,8 +276870,8 @@ def: "The has number of of a effector T cell." [AUTO:patterns/patterns/entity_at synonym: "has number of of effector T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000911 ! effector T cell -relationship: inheres_in CL:0000911 ! effector T cell +intersection_of: RO:0000052 CL:0000911 ! inheres in effector T cell +relationship: RO:0000052 CL:0000911 ! inheres in effector T cell [Term] id: OBA:VT0001835 @@ -175729,8 +276880,8 @@ def: "The quality of a antigen processing and presentation." [AUTO:patterns/patt synonym: "quality of antigen processing and presentation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0019882 ! antigen processing and presentation -relationship: inheres_in GO:0019882 ! antigen processing and presentation +intersection_of: RO:0000052 GO:0019882 ! inheres in antigen processing and presentation +relationship: RO:0000052 GO:0019882 ! inheres in antigen processing and presentation [Term] id: OBA:VT0001879 @@ -175740,7 +276891,7 @@ synonym: "morphology of lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000145 ! lymphatic vessel quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001473 ! lymphatic vessel +intersection_of: RO:0000052 UBERON:0001473 ! inheres in lymphatic vessel [Term] id: OBA:VT0001881 @@ -175749,8 +276900,8 @@ def: "The functionality of a mammary gland." [AUTO:patterns/patterns/entity_attr synonym: "functionality of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0001882 @@ -175759,8 +276910,8 @@ def: "The quality of a lactation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of lactation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001784 ! fluid regulation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007595 ! lactation -relationship: inheres_in GO:0007595 ! lactation +intersection_of: RO:0000052 GO:0007595 ! inheres in lactation +relationship: RO:0000052 GO:0007595 ! inheres in lactation [Term] id: OBA:VT0001884 @@ -175770,8 +276921,8 @@ synonym: "morphology of mammary gland alveolus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003214 ! mammary gland alveolus -relationship: inheres_in UBERON:0003214 ! mammary gland alveolus +intersection_of: RO:0000052 UBERON:0003214 ! inheres in mammary gland alveolus +relationship: RO:0000052 UBERON:0003214 ! inheres in mammary gland alveolus [Term] id: OBA:VT0001885 @@ -175780,8 +276931,8 @@ def: "The morphology of a mammary duct." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of mammary duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004750 ! epithelium of mammary gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001765 ! mammary duct -relationship: inheres_in UBERON:0001765 ! mammary duct +intersection_of: RO:0000052 UBERON:0001765 ! inheres in mammary duct +relationship: RO:0000052 UBERON:0001765 ! inheres in mammary duct [Term] id: OBA:VT0001905 @@ -175790,8 +276941,8 @@ def: "The amount of a dopamine." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of dopamine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000984 ! catecholamine amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:18243 ! dopamine -relationship: inheres_in CHEBI:18243 ! dopamine +intersection_of: RO:0000052 CHEBI:18243 ! inheres in dopamine +relationship: RO:0000052 CHEBI:18243 ! inheres in dopamine [Term] id: OBA:VT0001919 @@ -175801,7 +276952,7 @@ synonym: "functionality of reproductive system" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0005389 ! reproductive system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000990 ! reproductive system +intersection_of: RO:0000052 UBERON:0000990 ! inheres in reproductive system [Term] id: OBA:VT0001922 @@ -175811,8 +276962,8 @@ synonym: "fertility of maleate(2-)" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000274 ! fertility intersection_of: PATO:0000274 ! fertility -intersection_of: inheres_in CHEBI:30780 ! maleate(2-) -relationship: inheres_in CHEBI:30780 ! maleate(2-) +intersection_of: RO:0000052 CHEBI:30780 ! inheres in maleate(2-) +relationship: RO:0000052 CHEBI:30780 ! inheres in maleate(2-) [Term] id: OBA:VT0001923 @@ -175821,8 +276972,8 @@ def: "The quality of a female fertility." [AUTO:patterns/patterns/entity_attribu synonym: "quality of female fertility" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010464 ! fertility trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PATO:0000277 ! female fertility -relationship: inheres_in PATO:0000277 ! female fertility +intersection_of: RO:0000052 PATO:0000277 ! inheres in female fertility +relationship: RO:0000052 PATO:0000277 ! inheres in female fertility [Term] id: OBA:VT0001928 @@ -175831,8 +276982,8 @@ def: "The quality of a ovulation." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of ovulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030728 ! ovulation -relationship: inheres_in GO:0030728 ! ovulation +intersection_of: RO:0000052 GO:0030728 ! inheres in ovulation +relationship: RO:0000052 GO:0030728 ! inheres in ovulation [Term] id: OBA:VT0001930 @@ -175841,8 +276992,8 @@ def: "The quality of a http://purl.obolibrary.org/obo/GO_0007126." [AUTO:pattern synonym: "quality of http://purl.obolibrary.org/obo/GO_0007126" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007126 -relationship: inheres_in GO:0007126 +intersection_of: RO:0000052 GO:0007126 ! inheres in +relationship: RO:0000052 GO:0007126 ! inheres in [Term] id: OBA:VT0001931 @@ -175851,8 +277002,8 @@ def: "The quality of a oogenesis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of oogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048477 ! oogenesis -relationship: inheres_in GO:0048477 ! oogenesis +intersection_of: RO:0000052 GO:0048477 ! inheres in oogenesis +relationship: RO:0000052 GO:0048477 ! inheres in oogenesis [Term] id: OBA:VT0001932 @@ -175861,8 +277012,8 @@ def: "The quality of a spermatid development." [AUTO:patterns/patterns/entity_at synonym: "quality of spermatid development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007286 ! spermatid development -relationship: inheres_in GO:0007286 ! spermatid development +intersection_of: RO:0000052 GO:0007286 ! inheres in spermatid development +relationship: RO:0000052 GO:0007286 ! inheres in spermatid development [Term] id: OBA:VT0001942 @@ -175872,7 +277023,7 @@ synonym: "volume of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003641 ! lung size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:VT0001944 @@ -175882,8 +277033,8 @@ synonym: "morphology of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001264 ! pancreas -relationship: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas +relationship: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:VT0001961 @@ -175892,8 +277043,8 @@ def: "The quality of a reflex." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of reflex" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060004 ! reflex -relationship: inheres_in GO:0060004 ! reflex +intersection_of: RO:0000052 GO:0060004 ! inheres in reflex +relationship: RO:0000052 GO:0060004 ! inheres in reflex [Term] id: OBA:VT0001983 @@ -175903,8 +277054,8 @@ synonym: "functionality of chemosensory organ" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000005 ! chemosensory organ -relationship: inheres_in UBERON:0000005 ! chemosensory organ +intersection_of: RO:0000052 UBERON:0000005 ! inheres in chemosensory organ +relationship: RO:0000052 UBERON:0000005 ! inheres in chemosensory organ [Term] id: OBA:VT0001984 @@ -175913,8 +277064,8 @@ def: "The quality of a sensory perception of smell." [AUTO:patterns/patterns/ent synonym: "quality of sensory perception of smell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007608 ! sensory perception of smell -relationship: inheres_in GO:0007608 ! sensory perception of smell +intersection_of: RO:0000052 GO:0007608 ! inheres in sensory perception of smell +relationship: RO:0000052 GO:0007608 ! inheres in sensory perception of smell [Term] id: OBA:VT0001985 @@ -175924,7 +277075,7 @@ synonym: "functionality of gustatory system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0015065 ! gustatory system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001033 ! gustatory system +intersection_of: RO:0000052 UBERON:0001033 ! inheres in gustatory system [Term] id: OBA:VT0001986 @@ -175934,8 +277085,8 @@ synonym: "sensitivity toward of sensory perception of taste" EXACT [AUTO:pattern is_a: OBA:VT0015095 ! sensory trait is_a: PATO:0000085 ! sensitivity toward intersection_of: PATO:0000085 ! sensitivity toward -intersection_of: inheres_in GO:0050909 ! sensory perception of taste -relationship: inheres_in GO:0050909 ! sensory perception of taste +intersection_of: RO:0000052 GO:0050909 ! inheres in sensory perception of taste +relationship: RO:0000052 GO:0050909 ! inheres in sensory perception of taste [Term] id: OBA:VT0002059 @@ -175944,8 +277095,8 @@ def: "The morphology of a seminal vesicle." [AUTO:patterns/patterns/entity_attri synonym: "morphology of seminal vesicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005809 ! male reproductive gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000998 ! seminal vesicle -relationship: inheres_in UBERON:0000998 ! seminal vesicle +intersection_of: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle +relationship: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle [Term] id: OBA:VT0002068 @@ -175954,8 +277105,8 @@ def: "The quality of a parental behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of parental behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060746 ! parental behavior -relationship: inheres_in GO:0060746 ! parental behavior +intersection_of: RO:0000052 GO:0060746 ! inheres in parental behavior +relationship: RO:0000052 GO:0060746 ! inheres in parental behavior [Term] id: OBA:VT0002074 @@ -175965,7 +277116,7 @@ synonym: "texture of strand of hair" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000367 ! coat/hair morphology trait is_a: PATO:0000150 ! texture intersection_of: PATO:0000150 ! texture -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0002076 @@ -175975,8 +277126,8 @@ synonym: "morphology of hair follicle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002073 ! hair follicle -relationship: inheres_in UBERON:0002073 ! hair follicle +intersection_of: RO:0000052 UBERON:0002073 ! inheres in hair follicle +relationship: RO:0000052 UBERON:0002073 ! inheres in hair follicle [Term] id: OBA:VT0002086 @@ -175986,8 +277137,8 @@ synonym: "morphology of extraembryonic structure" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000478 ! extraembryonic structure -relationship: inheres_in UBERON:0000478 ! extraembryonic structure +intersection_of: RO:0000052 UBERON:0000478 ! inheres in extraembryonic structure +relationship: RO:0000052 UBERON:0000478 ! inheres in extraembryonic structure [Term] id: OBA:VT0002090 @@ -175996,8 +277147,8 @@ def: "The quality of a visual perception." [AUTO:patterns/patterns/entity_attrib synonym: "quality of visual perception" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007601 ! visual perception -relationship: inheres_in GO:0007601 ! visual perception +intersection_of: RO:0000052 GO:0007601 ! inheres in visual perception +relationship: RO:0000052 GO:0007601 ! inheres in visual perception [Term] id: OBA:VT0002092 @@ -176007,8 +277158,8 @@ synonym: "morphology of camera-type eye" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:VT0002096 @@ -176018,8 +277169,8 @@ synonym: "morphology of zone of skin" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:VT0002098 @@ -176028,8 +277179,8 @@ def: "The morphology of a strand of vibrissa hair." [AUTO:patterns/patterns/enti synonym: "morphology of strand of vibrissa hair" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000367 ! coat/hair morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006378 ! strand of vibrissa hair -relationship: inheres_in UBERON:0006378 ! strand of vibrissa hair +intersection_of: RO:0000052 UBERON:0006378 ! inheres in strand of vibrissa hair +relationship: RO:0000052 UBERON:0006378 ! inheres in strand of vibrissa hair [Term] id: OBA:VT0002100 @@ -176039,8 +277190,8 @@ synonym: "morphology of calcareous tooth" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001091 ! calcareous tooth -relationship: inheres_in UBERON:0001091 ! calcareous tooth +intersection_of: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth +relationship: RO:0000052 UBERON:0001091 ! inheres in calcareous tooth [Term] id: OBA:VT0002102 @@ -176050,8 +277201,8 @@ synonym: "morphology of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001690 ! ear -relationship: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear +relationship: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:VT0002104 @@ -176061,7 +277212,7 @@ synonym: "functionality of sensory perception of sound" EXACT [AUTO:patterns/pat is_a: OBA:1000931 ! sensory perception of sound quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in GO:0007605 ! sensory perception of sound +intersection_of: RO:0000052 GO:0007605 ! inheres in sensory perception of sound [Term] id: OBA:VT0002106 @@ -176071,7 +277222,7 @@ synonym: "functionality of musculature of body" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0005369 ! muscular system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000383 ! musculature of body +intersection_of: RO:0000052 UBERON:0000383 ! inheres in musculature of body [Term] id: OBA:VT0002108 @@ -176081,7 +277232,7 @@ synonym: "morphology of musculature of body" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0005369 ! muscular system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000383 ! musculature of body +intersection_of: RO:0000052 UBERON:0000383 ! inheres in musculature of body [Term] id: OBA:VT0002109 @@ -176090,8 +277241,8 @@ def: "The morphology of a limb." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of limb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015071 ! appendage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002101 ! limb -relationship: inheres_in UBERON:0002101 ! limb +intersection_of: RO:0000052 UBERON:0002101 ! inheres in limb +relationship: RO:0000052 UBERON:0002101 ! inheres in limb [Term] id: OBA:VT0002110 @@ -176101,7 +277252,7 @@ synonym: "morphology of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000577 ! digit quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:VT0002111 @@ -176111,8 +277262,8 @@ synonym: "morphology of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002415 ! tail -relationship: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail +relationship: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:VT0002114 @@ -176122,8 +277273,8 @@ synonym: "morphology of postcranial axial skeleton" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002090 ! postcranial axial skeleton -relationship: inheres_in UBERON:0002090 ! postcranial axial skeleton +intersection_of: RO:0000052 UBERON:0002090 ! inheres in postcranial axial skeleton +relationship: RO:0000052 UBERON:0002090 ! inheres in postcranial axial skeleton [Term] id: OBA:VT0002116 @@ -176132,8 +277283,8 @@ def: "The morphology of a head bone." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of head bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003457 ! head bone -relationship: inheres_in UBERON:0003457 ! head bone +intersection_of: RO:0000052 UBERON:0003457 ! inheres in head bone +relationship: RO:0000052 UBERON:0003457 ! inheres in head bone [Term] id: OBA:VT0002118 @@ -176142,8 +277293,8 @@ def: "The quality of a lipid homeostasis." [AUTO:patterns/patterns/entity_attrib synonym: "quality of lipid homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055088 ! lipid homeostasis -relationship: inheres_in GO:0055088 ! lipid homeostasis +intersection_of: RO:0000052 GO:0055088 ! inheres in lipid homeostasis +relationship: RO:0000052 GO:0055088 ! inheres in lipid homeostasis [Term] id: OBA:VT0002121 @@ -176152,8 +277303,8 @@ def: "The quality of a metabolic process." [AUTO:patterns/patterns/entity_attrib synonym: "quality of metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008152 ! metabolic process -relationship: inheres_in GO:0008152 ! metabolic process +intersection_of: RO:0000052 GO:0008152 ! inheres in metabolic process +relationship: RO:0000052 GO:0008152 ! inheres in metabolic process [Term] id: OBA:VT0002123 @@ -176162,8 +277313,8 @@ def: "The quality of a hemopoiesis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of hemopoiesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030097 ! hemopoiesis -relationship: inheres_in GO:0030097 ! hemopoiesis +intersection_of: RO:0000052 GO:0030097 ! inheres in hemopoiesis +relationship: RO:0000052 GO:0030097 ! inheres in hemopoiesis [Term] id: OBA:VT0002127 @@ -176173,8 +277324,8 @@ synonym: "morphology of cardiovascular system" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004535 ! cardiovascular system -relationship: inheres_in UBERON:0004535 ! cardiovascular system +intersection_of: RO:0000052 UBERON:0004535 ! inheres in cardiovascular system +relationship: RO:0000052 UBERON:0004535 ! inheres in cardiovascular system [Term] id: OBA:VT0002132 @@ -176184,7 +277335,7 @@ synonym: "morphology of respiratory system" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0005388 ! respiratory system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001004 ! respiratory system +intersection_of: RO:0000052 UBERON:0001004 ! inheres in respiratory system [Term] id: OBA:VT0002133 @@ -176194,7 +277345,7 @@ synonym: "functionality of respiratory system" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0005388 ! respiratory system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001004 ! respiratory system +intersection_of: RO:0000052 UBERON:0001004 ! inheres in respiratory system [Term] id: OBA:VT0002135 @@ -176204,8 +277355,8 @@ synonym: "morphology of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:VT0002136 @@ -176215,8 +277366,8 @@ synonym: "functionality of kidney" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:VT0002138 @@ -176226,8 +277377,8 @@ synonym: "morphology of hepatobiliary system" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002423 ! hepatobiliary system -relationship: inheres_in UBERON:0002423 ! hepatobiliary system +intersection_of: RO:0000052 UBERON:0002423 ! inheres in hepatobiliary system +relationship: RO:0000052 UBERON:0002423 ! inheres in hepatobiliary system [Term] id: OBA:VT0002139 @@ -176237,8 +277388,8 @@ synonym: "functionality of hepatobiliary system" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002423 ! hepatobiliary system -relationship: inheres_in UBERON:0002423 ! hepatobiliary system +intersection_of: RO:0000052 UBERON:0002423 ! inheres in hepatobiliary system +relationship: RO:0000052 UBERON:0002423 ! inheres in hepatobiliary system [Term] id: OBA:VT0002144 @@ -176247,8 +277398,8 @@ def: "The quality of a B cell differentiation." [AUTO:patterns/patterns/entity_a synonym: "quality of B cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030183 ! B cell differentiation -relationship: inheres_in GO:0030183 ! B cell differentiation +intersection_of: RO:0000052 GO:0030183 ! inheres in B cell differentiation +relationship: RO:0000052 GO:0030183 ! inheres in B cell differentiation [Term] id: OBA:VT0002145 @@ -176257,8 +277408,8 @@ def: "The quality of a T cell differentiation." [AUTO:patterns/patterns/entity_a synonym: "quality of T cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030217 ! T cell differentiation -relationship: inheres_in GO:0030217 ! T cell differentiation +intersection_of: RO:0000052 GO:0030217 ! inheres in T cell differentiation +relationship: RO:0000052 GO:0030217 ! inheres in T cell differentiation [Term] id: OBA:VT0002152 @@ -176268,8 +277419,8 @@ synonym: "morphology of brain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000955 ! brain -relationship: inheres_in UBERON:0000955 ! brain +intersection_of: RO:0000052 UBERON:0000955 ! inheres in brain +relationship: RO:0000052 UBERON:0000955 ! inheres in brain [Term] id: OBA:VT0002160 @@ -176279,7 +277430,7 @@ synonym: "morphology of reproductive system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0005389 ! reproductive system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000990 ! reproductive system +intersection_of: RO:0000052 UBERON:0000990 ! inheres in reproductive system [Term] id: OBA:VT0002163 @@ -176289,7 +277440,7 @@ synonym: "morphology of gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002530 ! gland +intersection_of: RO:0000052 UBERON:0002530 ! inheres in gland [Term] id: OBA:VT0002164 @@ -176299,7 +277450,7 @@ synonym: "functionality of gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000057 ! gland quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002530 ! gland +intersection_of: RO:0000052 UBERON:0002530 ! inheres in gland [Term] id: OBA:VT0002176 @@ -176309,8 +277460,8 @@ synonym: "mass of brain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000955 ! brain -relationship: inheres_in UBERON:0000955 ! brain +intersection_of: RO:0000052 UBERON:0000955 ! inheres in brain +relationship: RO:0000052 UBERON:0000955 ! inheres in brain [Term] id: OBA:VT0002177 @@ -176320,8 +277471,8 @@ synonym: "morphology of pinna" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001757 ! pinna -relationship: inheres_in UBERON:0001757 ! pinna +intersection_of: RO:0000052 UBERON:0001757 ! inheres in pinna +relationship: RO:0000052 UBERON:0001757 ! inheres in pinna [Term] id: OBA:VT0002181 @@ -176338,7 +277489,7 @@ synonym: "morphology of astrocyte" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000381 ! astrocyte quality is_a: OBA:VT0003634 ! glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000127 ! astrocyte +intersection_of: RO:0000052 CL:0000127 ! inheres in astrocyte [Term] id: OBA:VT0002184 @@ -176348,7 +277499,7 @@ synonym: "morphology of innervation" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000720 ! innervation quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0060384 ! innervation +intersection_of: RO:0000052 GO:0060384 ! inheres in innervation [Term] id: OBA:VT0002187 @@ -176358,7 +277509,7 @@ synonym: "morphology of fibula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000572 ! fibula quality is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:VT0002191 @@ -176367,8 +277518,8 @@ def: "The morphology of a artery." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001637 ! artery -relationship: inheres_in UBERON:0001637 ! artery +intersection_of: RO:0000052 UBERON:0001637 ! inheres in artery +relationship: RO:0000052 UBERON:0001637 ! inheres in artery [Term] id: OBA:VT0002199 @@ -176377,8 +277528,8 @@ def: "The morphology of a brain commissure." [AUTO:patterns/patterns/entity_attr synonym: "morphology of brain commissure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005970 ! brain commissure -relationship: inheres_in UBERON:0005970 ! brain commissure +intersection_of: RO:0000052 UBERON:0005970 ! inheres in brain commissure +relationship: RO:0000052 UBERON:0005970 ! inheres in brain commissure [Term] id: OBA:VT0002200 @@ -176388,8 +277539,8 @@ synonym: "morphology of brain ventricle/choroid plexus" EXACT [AUTO:patterns/pat is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003947 ! brain ventricle/choroid plexus -relationship: inheres_in UBERON:0003947 ! brain ventricle/choroid plexus +intersection_of: RO:0000052 UBERON:0003947 ! inheres in brain ventricle/choroid plexus +relationship: RO:0000052 UBERON:0003947 ! inheres in brain ventricle/choroid plexus [Term] id: OBA:VT0002208 @@ -176398,8 +277549,8 @@ def: "The morphology of a germ cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of germ cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000586 ! germ cell -relationship: inheres_in CL:0000586 ! germ cell +intersection_of: RO:0000052 CL:0000586 ! inheres in germ cell +relationship: RO:0000052 CL:0000586 ! inheres in germ cell [Term] id: OBA:VT0002209 @@ -176409,8 +277560,8 @@ synonym: "has number of of germ cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000586 ! germ cell -relationship: inheres_in CL:0000586 ! germ cell +intersection_of: RO:0000052 CL:0000586 ! inheres in germ cell +relationship: RO:0000052 CL:0000586 ! inheres in germ cell [Term] id: OBA:VT0002210 @@ -176419,8 +277570,8 @@ def: "The quality of a sex determination." [AUTO:patterns/patterns/entity_attrib synonym: "quality of sex determination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007530 ! sex determination -relationship: inheres_in GO:0007530 ! sex determination +intersection_of: RO:0000052 GO:0007530 ! inheres in sex determination +relationship: RO:0000052 GO:0007530 ! inheres in sex determination [Term] id: OBA:VT0002211 @@ -176429,8 +277580,8 @@ def: "The quality of a gonad development." [AUTO:patterns/patterns/entity_attrib synonym: "quality of gonad development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008406 ! gonad development -relationship: inheres_in GO:0008406 ! gonad development +intersection_of: RO:0000052 GO:0008406 ! inheres in gonad development +relationship: RO:0000052 GO:0008406 ! inheres in gonad development [Term] id: OBA:VT0002216 @@ -176440,8 +277591,8 @@ synonym: "morphology of seminiferous tubule of testis" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001343 ! seminiferous tubule of testis -relationship: inheres_in UBERON:0001343 ! seminiferous tubule of testis +intersection_of: RO:0000052 UBERON:0001343 ! inheres in seminiferous tubule of testis +relationship: RO:0000052 UBERON:0001343 ! inheres in seminiferous tubule of testis [Term] id: OBA:VT0002221 @@ -176451,7 +277602,7 @@ synonym: "size of immune organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005057 ! immune organ +intersection_of: RO:0000052 UBERON:0005057 ! inheres in immune organ [Term] id: OBA:VT0002224 @@ -176463,7 +277614,7 @@ is_a: OBA:0003537 ! spleen morphology is_a: OBA:0005812 ! abdominal viscera size is_a: OBA:VT0002221 ! immune system organ size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:VT0002227 @@ -176473,8 +277624,8 @@ synonym: "morphology of spleen capsule" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004641 ! spleen capsule -relationship: inheres_in UBERON:0004641 ! spleen capsule +intersection_of: RO:0000052 UBERON:0004641 ! inheres in spleen capsule +relationship: RO:0000052 UBERON:0004641 ! inheres in spleen capsule [Term] id: OBA:VT0002228 @@ -176483,8 +277634,8 @@ def: "The morphology of a spleen trabecular vein." [AUTO:patterns/patterns/entit synonym: "morphology of spleen trabecular vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010400 ! spleen trabecular vein -relationship: inheres_in UBERON:0010400 ! spleen trabecular vein +intersection_of: RO:0000052 UBERON:0010400 ! inheres in spleen trabecular vein +relationship: RO:0000052 UBERON:0010400 ! inheres in spleen trabecular vein [Term] id: OBA:VT0002231 @@ -176493,8 +277644,8 @@ def: "The morphology of a primitive streak." [AUTO:patterns/patterns/entity_attr synonym: "morphology of primitive streak" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004341 ! primitive streak -relationship: inheres_in UBERON:0004341 ! primitive streak +intersection_of: RO:0000052 UBERON:0004341 ! inheres in primitive streak +relationship: RO:0000052 UBERON:0004341 ! inheres in primitive streak [Term] id: OBA:VT0002233 @@ -176504,8 +277655,8 @@ synonym: "morphology of nose" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000004 ! nose -relationship: inheres_in UBERON:0000004 ! nose +intersection_of: RO:0000052 UBERON:0000004 ! inheres in nose +relationship: RO:0000052 UBERON:0000004 ! inheres in nose [Term] id: OBA:VT0002234 @@ -176515,8 +277666,8 @@ synonym: "morphology of chordate pharynx" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001042 ! chordate pharynx -relationship: inheres_in UBERON:0001042 ! chordate pharynx +intersection_of: RO:0000052 UBERON:0001042 ! inheres in chordate pharynx +relationship: RO:0000052 UBERON:0001042 ! inheres in chordate pharynx [Term] id: OBA:VT0002235 @@ -176525,8 +277676,8 @@ def: "The morphology of a external naris." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of external naris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005928 ! external naris -relationship: inheres_in UBERON:0005928 ! external naris +intersection_of: RO:0000052 UBERON:0005928 ! inheres in external naris +relationship: RO:0000052 UBERON:0005928 ! inheres in external naris [Term] id: OBA:VT0002236 @@ -176536,8 +277687,8 @@ synonym: "morphology of posterior nasal aperture" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004771 ! posterior nasal aperture -relationship: inheres_in UBERON:0004771 ! posterior nasal aperture +intersection_of: RO:0000052 UBERON:0004771 ! inheres in posterior nasal aperture +relationship: RO:0000052 UBERON:0004771 ! inheres in posterior nasal aperture [Term] id: OBA:VT0002237 @@ -176547,7 +277698,7 @@ synonym: "morphology of nasal cavity" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000277 ! nasal cavity quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001707 ! nasal cavity +intersection_of: RO:0000052 UBERON:0001707 ! inheres in nasal cavity [Term] id: OBA:VT0002238 @@ -176556,8 +277707,8 @@ def: "The morphology of a nasal cavity epithelium." [AUTO:patterns/patterns/enti synonym: "morphology of nasal cavity epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005279 ! respiratory tract epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005384 ! nasal cavity epithelium -relationship: inheres_in UBERON:0005384 ! nasal cavity epithelium +intersection_of: RO:0000052 UBERON:0005384 ! inheres in nasal cavity epithelium +relationship: RO:0000052 UBERON:0005384 ! inheres in nasal cavity epithelium [Term] id: OBA:VT0002239 @@ -176567,8 +277718,8 @@ synonym: "morphology of nasal septum" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001706 ! nasal septum -relationship: inheres_in UBERON:0001706 ! nasal septum +intersection_of: RO:0000052 UBERON:0001706 ! inheres in nasal septum +relationship: RO:0000052 UBERON:0001706 ! inheres in nasal septum [Term] id: OBA:VT0002240 @@ -176578,7 +277729,7 @@ synonym: "morphology of paranasal sinus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000172 ! paranasal sinus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001825 ! paranasal sinus +intersection_of: RO:0000052 UBERON:0001825 ! inheres in paranasal sinus [Term] id: OBA:VT0002242 @@ -176587,8 +277738,8 @@ def: "The morphology of a olfactory segment of nasal mucosa." [AUTO:patterns/pat synonym: "morphology of olfactory segment of nasal mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002277 ! respiratory mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005386 ! olfactory segment of nasal mucosa -relationship: inheres_in UBERON:0005386 ! olfactory segment of nasal mucosa +intersection_of: RO:0000052 UBERON:0005386 ! inheres in olfactory segment of nasal mucosa +relationship: RO:0000052 UBERON:0005386 ! inheres in olfactory segment of nasal mucosa [Term] id: OBA:VT0002243 @@ -176598,8 +277749,8 @@ synonym: "morphology of vomeronasal organ" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002255 ! vomeronasal organ -relationship: inheres_in UBERON:0002255 ! vomeronasal organ +intersection_of: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ +relationship: RO:0000052 UBERON:0002255 ! inheres in vomeronasal organ [Term] id: OBA:VT0002244 @@ -176609,8 +277760,8 @@ synonym: "morphology of turbinate bone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001762 ! turbinate bone -relationship: inheres_in UBERON:0001762 ! turbinate bone +intersection_of: RO:0000052 UBERON:0001762 ! inheres in turbinate bone +relationship: RO:0000052 UBERON:0001762 ! inheres in turbinate bone [Term] id: OBA:VT0002245 @@ -176620,7 +277771,7 @@ synonym: "morphology of ethmoid sinus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000512 ! ethmoid sinus quality is_a: OBA:VT0002240 ! paranasal sinus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002453 ! ethmoid sinus +intersection_of: RO:0000052 UBERON:0002453 ! inheres in ethmoid sinus [Term] id: OBA:VT0002246 @@ -176630,7 +277781,7 @@ synonym: "morphology of frontal sinus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000363 ! frontal sinus quality is_a: OBA:VT0002240 ! paranasal sinus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001760 ! frontal sinus +intersection_of: RO:0000052 UBERON:0001760 ! inheres in frontal sinus [Term] id: OBA:VT0002248 @@ -176640,7 +277791,7 @@ synonym: "morphology of sphenoidal sinus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000162 ! sphenoidal sinus quality is_a: OBA:VT0002240 ! paranasal sinus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001724 ! sphenoidal sinus +intersection_of: RO:0000052 UBERON:0001724 ! inheres in sphenoidal sinus [Term] id: OBA:VT0002249 @@ -176650,8 +277801,8 @@ synonym: "morphology of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001737 ! larynx -relationship: inheres_in UBERON:0001737 ! larynx +intersection_of: RO:0000052 UBERON:0001737 ! inheres in larynx +relationship: RO:0000052 UBERON:0001737 ! inheres in larynx [Term] id: OBA:VT0002250 @@ -176661,7 +277812,7 @@ synonym: "morphology of hypopharynx" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000570 ! hypopharynx quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001051 ! hypopharynx +intersection_of: RO:0000052 UBERON:0001051 ! inheres in hypopharynx [Term] id: OBA:VT0002251 @@ -176671,8 +277822,8 @@ synonym: "morphology of nasopharynx" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001728 ! nasopharynx -relationship: inheres_in UBERON:0001728 ! nasopharynx +intersection_of: RO:0000052 UBERON:0001728 ! inheres in nasopharynx +relationship: RO:0000052 UBERON:0001728 ! inheres in nasopharynx [Term] id: OBA:VT0002252 @@ -176682,8 +277833,8 @@ synonym: "morphology of oropharynx" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001729 ! oropharynx -relationship: inheres_in UBERON:0001729 ! oropharynx +intersection_of: RO:0000052 UBERON:0001729 ! inheres in oropharynx +relationship: RO:0000052 UBERON:0001729 ! inheres in oropharynx [Term] id: OBA:VT0002253 @@ -176692,8 +277843,8 @@ def: "The morphology of a pharyngeal muscle." [AUTO:patterns/patterns/entity_att synonym: "morphology of pharyngeal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000933 ! pharyngeal muscle -relationship: inheres_in UBERON:0000933 ! pharyngeal muscle +intersection_of: RO:0000052 UBERON:0000933 ! inheres in pharyngeal muscle +relationship: RO:0000052 UBERON:0000933 ! inheres in pharyngeal muscle [Term] id: OBA:VT0002255 @@ -176703,8 +277854,8 @@ synonym: "morphology of glottis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002486 ! glottis -relationship: inheres_in UBERON:0002486 ! glottis +intersection_of: RO:0000052 UBERON:0002486 ! inheres in glottis +relationship: RO:0000052 UBERON:0002486 ! inheres in glottis [Term] id: OBA:VT0002256 @@ -176713,8 +277864,8 @@ def: "The morphology of a laryngeal cartilage." [AUTO:patterns/patterns/entity_a synonym: "morphology of laryngeal cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001739 ! laryngeal cartilage -relationship: inheres_in UBERON:0001739 ! laryngeal cartilage +intersection_of: RO:0000052 UBERON:0001739 ! inheres in laryngeal cartilage +relationship: RO:0000052 UBERON:0001739 ! inheres in laryngeal cartilage [Term] id: OBA:VT0002257 @@ -176723,8 +277874,8 @@ def: "The morphology of a arytenoid cartilage." [AUTO:patterns/patterns/entity_a synonym: "morphology of arytenoid cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002256 ! laryngeal cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001740 ! arytenoid cartilage -relationship: inheres_in UBERON:0001740 ! arytenoid cartilage +intersection_of: RO:0000052 UBERON:0001740 ! inheres in arytenoid cartilage +relationship: RO:0000052 UBERON:0001740 ! inheres in arytenoid cartilage [Term] id: OBA:VT0002258 @@ -176734,7 +277885,7 @@ synonym: "morphology of cricoid cartilage" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000586 ! cricoid cartilage quality is_a: OBA:VT0002256 ! laryngeal cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002375 ! cricoid cartilage +intersection_of: RO:0000052 UBERON:0002375 ! inheres in cricoid cartilage [Term] id: OBA:VT0002259 @@ -176744,8 +277895,8 @@ synonym: "morphology of epiglottis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000388 ! epiglottis -relationship: inheres_in UBERON:0000388 ! epiglottis +intersection_of: RO:0000052 UBERON:0000388 ! inheres in epiglottis +relationship: RO:0000052 UBERON:0000388 ! inheres in epiglottis [Term] id: OBA:VT0002260 @@ -176754,8 +277905,8 @@ def: "The morphology of a thyroid cartilage." [AUTO:patterns/patterns/entity_att synonym: "morphology of thyroid cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002256 ! laryngeal cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001738 ! thyroid cartilage -relationship: inheres_in UBERON:0001738 ! thyroid cartilage +intersection_of: RO:0000052 UBERON:0001738 ! inheres in thyroid cartilage +relationship: RO:0000052 UBERON:0001738 ! inheres in thyroid cartilage [Term] id: OBA:VT0002261 @@ -176764,8 +277915,8 @@ def: "The morphology of a mucosa of larynx." [AUTO:patterns/patterns/entity_attr synonym: "morphology of mucosa of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002277 ! respiratory mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001824 ! mucosa of larynx -relationship: inheres_in UBERON:0001824 ! mucosa of larynx +intersection_of: RO:0000052 UBERON:0001824 ! inheres in mucosa of larynx +relationship: RO:0000052 UBERON:0001824 ! inheres in mucosa of larynx [Term] id: OBA:VT0002262 @@ -176774,8 +277925,8 @@ def: "The morphology of a nasal mucosa goblet cell." [AUTO:patterns/patterns/ent synonym: "morphology of nasal mucosa goblet cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002480 ! nasal mucosa goblet cell -relationship: inheres_in CL:0002480 ! nasal mucosa goblet cell +intersection_of: RO:0000052 CL:0002480 ! inheres in nasal mucosa goblet cell +relationship: RO:0000052 CL:0002480 ! inheres in nasal mucosa goblet cell [Term] id: OBA:VT0002263 @@ -176784,8 +277935,8 @@ def: "The morphology of a muscle of larynx." [AUTO:patterns/patterns/entity_attr synonym: "morphology of muscle of larynx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001568 ! muscle of larynx -relationship: inheres_in UBERON:0001568 ! muscle of larynx +intersection_of: RO:0000052 UBERON:0001568 ! inheres in muscle of larynx +relationship: RO:0000052 UBERON:0001568 ! inheres in muscle of larynx [Term] id: OBA:VT0002264 @@ -176794,8 +277945,8 @@ def: "The morphology of a bronchus." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002185 ! bronchus -relationship: inheres_in UBERON:0002185 ! bronchus +intersection_of: RO:0000052 UBERON:0002185 ! inheres in bronchus +relationship: RO:0000052 UBERON:0002185 ! inheres in bronchus [Term] id: OBA:VT0002265 @@ -176804,8 +277955,8 @@ def: "The morphology of a left main bronchus." [AUTO:patterns/patterns/entity_at synonym: "morphology of left main bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002264 ! bronchus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002178 ! left main bronchus -relationship: inheres_in UBERON:0002178 ! left main bronchus +intersection_of: RO:0000052 UBERON:0002178 ! inheres in left main bronchus +relationship: RO:0000052 UBERON:0002178 ! inheres in left main bronchus [Term] id: OBA:VT0002266 @@ -176814,8 +277965,8 @@ def: "The morphology of a right main bronchus." [AUTO:patterns/patterns/entity_a synonym: "morphology of right main bronchus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002264 ! bronchus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002177 ! right main bronchus -relationship: inheres_in UBERON:0002177 ! right main bronchus +intersection_of: RO:0000052 UBERON:0002177 ! inheres in right main bronchus +relationship: RO:0000052 UBERON:0002177 ! inheres in right main bronchus [Term] id: OBA:VT0002267 @@ -176824,8 +277975,8 @@ def: "The morphology of a bronchiole." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of bronchiole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002186 ! bronchiole -relationship: inheres_in UBERON:0002186 ! bronchiole +intersection_of: RO:0000052 UBERON:0002186 ! inheres in bronchiole +relationship: RO:0000052 UBERON:0002186 ! inheres in bronchiole [Term] id: OBA:VT0002268 @@ -176834,8 +277985,8 @@ def: "The morphology of a terminal bronchiole." [AUTO:patterns/patterns/entity_a synonym: "morphology of terminal bronchiole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002267 ! bronchiole morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002187 ! terminal bronchiole -relationship: inheres_in UBERON:0002187 ! terminal bronchiole +intersection_of: RO:0000052 UBERON:0002187 ! inheres in terminal bronchiole +relationship: RO:0000052 UBERON:0002187 ! inheres in terminal bronchiole [Term] id: OBA:VT0002270 @@ -176845,8 +277996,8 @@ synonym: "morphology of alveolus of lung" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002299 ! alveolus of lung -relationship: inheres_in UBERON:0002299 ! alveolus of lung +intersection_of: RO:0000052 UBERON:0002299 ! inheres in alveolus of lung +relationship: RO:0000052 UBERON:0002299 ! inheres in alveolus of lung [Term] id: OBA:VT0002271 @@ -176855,8 +278006,8 @@ def: "The morphology of a pulmonary alveolar duct." [AUTO:patterns/patterns/enti synonym: "morphology of pulmonary alveolar duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002173 ! pulmonary alveolar duct -relationship: inheres_in UBERON:0002173 ! pulmonary alveolar duct +intersection_of: RO:0000052 UBERON:0002173 ! inheres in pulmonary alveolar duct +relationship: RO:0000052 UBERON:0002173 ! inheres in pulmonary alveolar duct [Term] id: OBA:VT0002273 @@ -176865,8 +278016,8 @@ def: "The morphology of a pneumocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of pneumocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000322 ! pneumocyte -relationship: inheres_in CL:0000322 ! pneumocyte +intersection_of: RO:0000052 CL:0000322 ! inheres in pneumocyte +relationship: RO:0000052 CL:0000322 ! inheres in pneumocyte [Term] id: OBA:VT0002274 @@ -176875,8 +278026,8 @@ def: "The morphology of a type I pneumocyte." [AUTO:patterns/patterns/entity_att synonym: "morphology of type I pneumocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002273 ! respiratory alveolar epithelial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002062 ! type I pneumocyte -relationship: inheres_in CL:0002062 ! type I pneumocyte +intersection_of: RO:0000052 CL:0002062 ! inheres in type I pneumocyte +relationship: RO:0000052 CL:0002062 ! inheres in type I pneumocyte [Term] id: OBA:VT0002275 @@ -176885,8 +278036,8 @@ def: "The morphology of a type II pneumocyte." [AUTO:patterns/patterns/entity_at synonym: "morphology of type II pneumocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002273 ! respiratory alveolar epithelial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002063 ! type II pneumocyte -relationship: inheres_in CL:0002063 ! type II pneumocyte +intersection_of: RO:0000052 CL:0002063 ! inheres in type II pneumocyte +relationship: RO:0000052 CL:0002063 ! inheres in type II pneumocyte [Term] id: OBA:VT0002276 @@ -176895,8 +278046,8 @@ def: "The morphology of a lung connective tissue." [AUTO:patterns/patterns/entit synonym: "morphology of lung connective tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000114 ! lung connective tissue -relationship: inheres_in UBERON:0000114 ! lung connective tissue +intersection_of: RO:0000052 UBERON:0000114 ! inheres in lung connective tissue +relationship: RO:0000052 UBERON:0000114 ! inheres in lung connective tissue [Term] id: OBA:VT0002277 @@ -176906,8 +278057,8 @@ synonym: "morphology of respiratory system mucosa" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004785 ! respiratory system mucosa -relationship: inheres_in UBERON:0004785 ! respiratory system mucosa +intersection_of: RO:0000052 UBERON:0004785 ! inheres in respiratory system mucosa +relationship: RO:0000052 UBERON:0004785 ! inheres in respiratory system mucosa [Term] id: OBA:VT0002278 @@ -176916,8 +278067,8 @@ def: "The morphology of a respiratory muscle." [AUTO:patterns/patterns/entity_at synonym: "morphology of respiratory muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014398 ! respiratory muscle -relationship: inheres_in UBERON:0014398 ! respiratory muscle +intersection_of: RO:0000052 UBERON:0014398 ! inheres in respiratory muscle +relationship: RO:0000052 UBERON:0014398 ! inheres in respiratory muscle [Term] id: OBA:VT0002279 @@ -176926,8 +278077,8 @@ def: "The morphology of a diaphragm." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:VT0002280 @@ -176936,8 +278087,8 @@ def: "The morphology of a intercostal muscle." [AUTO:patterns/patterns/entity_at synonym: "morphology of intercostal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001111 ! intercostal muscle -relationship: inheres_in UBERON:0001111 ! intercostal muscle +intersection_of: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle +relationship: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle [Term] id: OBA:VT0002282 @@ -176946,8 +278097,8 @@ def: "The morphology of a trachea." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004391 ! respiratory conducting tube morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003126 ! trachea -relationship: inheres_in UBERON:0003126 ! trachea +intersection_of: RO:0000052 UBERON:0003126 ! inheres in trachea +relationship: RO:0000052 UBERON:0003126 ! inheres in trachea [Term] id: OBA:VT0002284 @@ -176956,8 +278107,8 @@ def: "The morphology of a smooth muscle of trachea." [AUTO:patterns/patterns/ent synonym: "morphology of smooth muscle of trachea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003387 ! smooth muscle of trachea -relationship: inheres_in UBERON:0003387 ! smooth muscle of trachea +intersection_of: RO:0000052 UBERON:0003387 ! inheres in smooth muscle of trachea +relationship: RO:0000052 UBERON:0003387 ! inheres in smooth muscle of trachea [Term] id: OBA:VT0002292 @@ -176967,8 +278118,8 @@ synonym: "duration of female pregnancy" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100002 ! biological process attribute is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration -intersection_of: inheres_in GO:0007565 ! female pregnancy -relationship: inheres_in GO:0007565 ! female pregnancy +intersection_of: RO:0000052 GO:0007565 ! inheres in female pregnancy +relationship: RO:0000052 GO:0007565 ! inheres in female pregnancy [Term] id: OBA:VT0002324 @@ -176978,8 +278129,8 @@ synonym: "morphology of blood-air barrier" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003948 ! blood-air barrier -relationship: inheres_in UBERON:0003948 ! blood-air barrier +intersection_of: RO:0000052 UBERON:0003948 ! inheres in blood-air barrier +relationship: RO:0000052 UBERON:0003948 ! inheres in blood-air barrier [Term] id: OBA:VT0002339 @@ -176989,7 +278140,7 @@ synonym: "structure of lymph node" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003703 ! lymph node morphology is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure -intersection_of: inheres_in UBERON:0000029 ! lymph node +intersection_of: RO:0000052 UBERON:0000029 ! inheres in lymph node [Term] id: OBA:VT0002340 @@ -176998,8 +278149,8 @@ def: "The morphology of a axillary lymph node." [AUTO:patterns/patterns/entity_a synonym: "morphology of axillary lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008463 ! peripheral lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001097 ! axillary lymph node -relationship: inheres_in UBERON:0001097 ! axillary lymph node +intersection_of: RO:0000052 UBERON:0001097 ! inheres in axillary lymph node +relationship: RO:0000052 UBERON:0001097 ! inheres in axillary lymph node [Term] id: OBA:VT0002342 @@ -177009,7 +278160,7 @@ synonym: "morphology of trabecula of lymph node" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000710 ! trabecula of lymph node quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002195 ! trabecula of lymph node +intersection_of: RO:0000052 UBERON:0002195 ! inheres in trabecula of lymph node [Term] id: OBA:VT0002343 @@ -177019,7 +278170,7 @@ synonym: "morphology of cortex of lymph node" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000730 ! cortex of lymph node quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002006 ! cortex of lymph node +intersection_of: RO:0000052 UBERON:0002006 ! inheres in cortex of lymph node [Term] id: OBA:VT0002344 @@ -177029,7 +278180,7 @@ synonym: "morphology of lymph node B cell domain" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000822 ! lymph node B cell domain quality is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010416 ! lymph node B cell domain +intersection_of: RO:0000052 UBERON:0010416 ! inheres in lymph node B cell domain [Term] id: OBA:VT0002345 @@ -177039,7 +278190,7 @@ synonym: "morphology of lymph node primary follicle" EXACT [AUTO:patterns/patter is_a: OBA:1000787 ! lymph node primary follicle quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010395 ! lymph node primary follicle +intersection_of: RO:0000052 UBERON:0010395 ! inheres in lymph node primary follicle [Term] id: OBA:VT0002346 @@ -177049,8 +278200,8 @@ synonym: "morphology of secondary nodular lymphoid tissue" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001745 ! secondary nodular lymphoid tissue -relationship: inheres_in UBERON:0001745 ! secondary nodular lymphoid tissue +intersection_of: RO:0000052 UBERON:0001745 ! inheres in secondary nodular lymphoid tissue +relationship: RO:0000052 UBERON:0001745 ! inheres in secondary nodular lymphoid tissue [Term] id: OBA:VT0002347 @@ -177060,7 +278211,7 @@ synonym: "morphology of lymph node T cell domain" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000736 ! lymph node T cell domain quality is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010417 ! lymph node T cell domain +intersection_of: RO:0000052 UBERON:0010417 ! inheres in lymph node T cell domain [Term] id: OBA:VT0002348 @@ -177070,7 +278221,7 @@ synonym: "morphology of medulla of lymph node" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000836 ! medulla of lymph node quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002007 ! medulla of lymph node +intersection_of: RO:0000052 UBERON:0002007 ! inheres in medulla of lymph node [Term] id: OBA:VT0002349 @@ -177079,8 +278230,8 @@ def: "The morphology of a afferent lymphatic vessel." [AUTO:patterns/patterns/en synonym: "morphology of afferent lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001879 ! lymphatic vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010396 ! afferent lymphatic vessel -relationship: inheres_in UBERON:0010396 ! afferent lymphatic vessel +intersection_of: RO:0000052 UBERON:0010396 ! inheres in afferent lymphatic vessel +relationship: RO:0000052 UBERON:0010396 ! inheres in afferent lymphatic vessel [Term] id: OBA:VT0002350 @@ -177089,8 +278240,8 @@ def: "The morphology of a efferent lymphatic vessel." [AUTO:patterns/patterns/en synonym: "morphology of efferent lymphatic vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001879 ! lymphatic vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010397 ! efferent lymphatic vessel -relationship: inheres_in UBERON:0010397 ! efferent lymphatic vessel +intersection_of: RO:0000052 UBERON:0010397 ! inheres in efferent lymphatic vessel +relationship: RO:0000052 UBERON:0010397 ! inheres in efferent lymphatic vessel [Term] id: OBA:VT0002351 @@ -177099,8 +278250,8 @@ def: "The morphology of a cervical lymph node." [AUTO:patterns/patterns/entity_a synonym: "morphology of cervical lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003703 ! lymph node morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002429 ! cervical lymph node -relationship: inheres_in UBERON:0002429 ! cervical lymph node +intersection_of: RO:0000052 UBERON:0002429 ! inheres in cervical lymph node +relationship: RO:0000052 UBERON:0002429 ! inheres in cervical lymph node [Term] id: OBA:VT0002352 @@ -177109,8 +278260,8 @@ def: "The morphology of a popliteal lymph node." [AUTO:patterns/patterns/entity_ synonym: "morphology of popliteal lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008463 ! peripheral lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001543 ! popliteal lymph node -relationship: inheres_in UBERON:0001543 ! popliteal lymph node +intersection_of: RO:0000052 UBERON:0001543 ! inheres in popliteal lymph node +relationship: RO:0000052 UBERON:0001543 ! inheres in popliteal lymph node [Term] id: OBA:VT0002353 @@ -177119,8 +278270,8 @@ def: "The morphology of a inguinal lymph node." [AUTO:patterns/patterns/entity_a synonym: "morphology of inguinal lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008463 ! peripheral lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001542 ! inguinal lymph node -relationship: inheres_in UBERON:0001542 ! inguinal lymph node +intersection_of: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node +relationship: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node [Term] id: OBA:VT0002354 @@ -177129,8 +278280,8 @@ def: "The morphology of a spleen trabecular artery." [AUTO:patterns/patterns/ent synonym: "morphology of spleen trabecular artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010399 ! spleen trabecular artery -relationship: inheres_in UBERON:0010399 ! spleen trabecular artery +intersection_of: RO:0000052 UBERON:0010399 ! inheres in spleen trabecular artery +relationship: RO:0000052 UBERON:0010399 ! inheres in spleen trabecular artery [Term] id: OBA:VT0002356 @@ -177140,8 +278291,8 @@ synonym: "morphology of red pulp of spleen" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001250 ! red pulp of spleen -relationship: inheres_in UBERON:0001250 ! red pulp of spleen +intersection_of: RO:0000052 UBERON:0001250 ! inheres in red pulp of spleen +relationship: RO:0000052 UBERON:0001250 ! inheres in red pulp of spleen [Term] id: OBA:VT0002357 @@ -177151,8 +278302,8 @@ synonym: "morphology of white pulp of spleen" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001959 ! white pulp of spleen -relationship: inheres_in UBERON:0001959 ! white pulp of spleen +intersection_of: RO:0000052 UBERON:0001959 ! inheres in white pulp of spleen +relationship: RO:0000052 UBERON:0001959 ! inheres in white pulp of spleen [Term] id: OBA:VT0002358 @@ -177162,8 +278313,8 @@ synonym: "morphology of periarterial lymphatic sheath" EXACT [AUTO:patterns/patt is_a: OBA:0003737 ! hemopoietic organ morphology is_a: OBA:VT0002722 ! immune system organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001960 ! periarterial lymphatic sheath -relationship: inheres_in UBERON:0001960 ! periarterial lymphatic sheath +intersection_of: RO:0000052 UBERON:0001960 ! inheres in periarterial lymphatic sheath +relationship: RO:0000052 UBERON:0001960 ! inheres in periarterial lymphatic sheath [Term] id: OBA:VT0002359 @@ -177173,8 +278324,8 @@ synonym: "morphology of spleen germinal center" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005196 ! spleen germinal center -relationship: inheres_in UBERON:0005196 ! spleen germinal center +intersection_of: RO:0000052 UBERON:0005196 ! inheres in spleen germinal center +relationship: RO:0000052 UBERON:0005196 ! inheres in spleen germinal center [Term] id: OBA:VT0002360 @@ -177184,8 +278335,8 @@ synonym: "morphology of spleen B cell corona" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010421 ! spleen B cell corona -relationship: inheres_in UBERON:0010421 ! spleen B cell corona +intersection_of: RO:0000052 UBERON:0010421 ! inheres in spleen B cell corona +relationship: RO:0000052 UBERON:0010421 ! inheres in spleen B cell corona [Term] id: OBA:VT0002361 @@ -177194,8 +278345,8 @@ def: "The morphology of a spleen central arteriole." [AUTO:patterns/patterns/ent synonym: "morphology of spleen central arteriole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003912 ! arteriole morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010401 ! spleen central arteriole -relationship: inheres_in UBERON:0010401 ! spleen central arteriole +intersection_of: RO:0000052 UBERON:0010401 ! inheres in spleen central arteriole +relationship: RO:0000052 UBERON:0010401 ! inheres in spleen central arteriole [Term] id: OBA:VT0002362 @@ -177205,8 +278356,8 @@ synonym: "morphology of marginal zone of spleen" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001251 ! marginal zone of spleen -relationship: inheres_in UBERON:0001251 ! marginal zone of spleen +intersection_of: RO:0000052 UBERON:0001251 ! inheres in marginal zone of spleen +relationship: RO:0000052 UBERON:0001251 ! inheres in marginal zone of spleen [Term] id: OBA:VT0002363 @@ -177215,8 +278366,8 @@ def: "The morphology of a spleen marginal sinus." [AUTO:patterns/patterns/entity synonym: "morphology of spleen marginal sinus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002357 ! spleen white pulp morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010398 ! spleen marginal sinus -relationship: inheres_in UBERON:0010398 ! spleen marginal sinus +intersection_of: RO:0000052 UBERON:0010398 ! inheres in spleen marginal sinus +relationship: RO:0000052 UBERON:0010398 ! inheres in spleen marginal sinus [Term] id: OBA:VT0002364 @@ -177227,7 +278378,7 @@ is_a: OBA:0003535 ! hemopoietic organ size is_a: OBA:0003539 ! thymus morphology is_a: OBA:VT0002221 ! immune system organ size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:VT0002367 @@ -177237,8 +278388,8 @@ synonym: "morphology of thymus lobule" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002125 ! thymus lobule -relationship: inheres_in UBERON:0002125 ! thymus lobule +intersection_of: RO:0000052 UBERON:0002125 ! inheres in thymus lobule +relationship: RO:0000052 UBERON:0002125 ! inheres in thymus lobule [Term] id: OBA:VT0002368 @@ -177248,8 +278399,8 @@ synonym: "morphology of capsule of thymus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002122 ! capsule of thymus -relationship: inheres_in UBERON:0002122 ! capsule of thymus +intersection_of: RO:0000052 UBERON:0002122 ! inheres in capsule of thymus +relationship: RO:0000052 UBERON:0002122 ! inheres in capsule of thymus [Term] id: OBA:VT0002369 @@ -177258,8 +278409,8 @@ def: "The morphology of a thymus subcapsular epithelium." [AUTO:patterns/pattern synonym: "morphology of thymus subcapsular epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0009544 ! thymus epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006936 ! thymus subcapsular epithelium -relationship: inheres_in UBERON:0006936 ! thymus subcapsular epithelium +intersection_of: RO:0000052 UBERON:0006936 ! inheres in thymus subcapsular epithelium +relationship: RO:0000052 UBERON:0006936 ! inheres in thymus subcapsular epithelium [Term] id: OBA:VT0002370 @@ -177269,8 +278420,8 @@ synonym: "morphology of thymus trabecula" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004791 ! thymus trabecula -relationship: inheres_in UBERON:0004791 ! thymus trabecula +intersection_of: RO:0000052 UBERON:0004791 ! inheres in thymus trabecula +relationship: RO:0000052 UBERON:0004791 ! inheres in thymus trabecula [Term] id: OBA:VT0002371 @@ -177280,8 +278431,8 @@ synonym: "morphology of cortex of thymus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002123 ! cortex of thymus -relationship: inheres_in UBERON:0002123 ! cortex of thymus +intersection_of: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus +relationship: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus [Term] id: OBA:VT0002375 @@ -177291,8 +278442,8 @@ synonym: "morphology of medulla of thymus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002124 ! medulla of thymus -relationship: inheres_in UBERON:0002124 ! medulla of thymus +intersection_of: RO:0000052 UBERON:0002124 ! inheres in medulla of thymus +relationship: RO:0000052 UBERON:0002124 ! inheres in medulla of thymus [Term] id: OBA:VT0002376 @@ -177302,8 +278453,8 @@ synonym: "dendritic of cellular process" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100002 ! biological process attribute is_a: PATO:0002045 ! dendritic intersection_of: PATO:0002045 ! dendritic -intersection_of: inheres_in GO:0009987 ! cellular process -relationship: inheres_in GO:0009987 ! cellular process +intersection_of: RO:0000052 GO:0009987 ! inheres in cellular process +relationship: RO:0000052 GO:0009987 ! inheres in cellular process [Term] id: OBA:VT0002377 @@ -177313,8 +278464,8 @@ synonym: "morphology of mucosa-associated lymphoid tissue" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001961 ! mucosa-associated lymphoid tissue -relationship: inheres_in UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: RO:0000052 UBERON:0001961 ! inheres in mucosa-associated lymphoid tissue +relationship: RO:0000052 UBERON:0001961 ! inheres in mucosa-associated lymphoid tissue [Term] id: OBA:VT0002378 @@ -177323,8 +278474,8 @@ def: "The morphology of a gut-associated lymphoid tissue." [AUTO:patterns/patter synonym: "morphology of gut-associated lymphoid tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002377 ! mucosa-associated lymphoid tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001962 ! gut-associated lymphoid tissue -relationship: inheres_in UBERON:0001962 ! gut-associated lymphoid tissue +intersection_of: RO:0000052 UBERON:0001962 ! inheres in gut-associated lymphoid tissue +relationship: RO:0000052 UBERON:0001962 ! inheres in gut-associated lymphoid tissue [Term] id: OBA:VT0002379 @@ -177333,8 +278484,8 @@ def: "The morphology of a tonsillar ring." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of tonsillar ring" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002378 ! gut-associated lymphoid tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001735 ! tonsillar ring -relationship: inheres_in UBERON:0001735 ! tonsillar ring +intersection_of: RO:0000052 UBERON:0001735 ! inheres in tonsillar ring +relationship: RO:0000052 UBERON:0001735 ! inheres in tonsillar ring [Term] id: OBA:VT0002380 @@ -177343,8 +278494,8 @@ def: "The morphology of a palatine tonsil." [AUTO:patterns/patterns/entity_attri synonym: "morphology of palatine tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003705 ! tonsil morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002373 ! palatine tonsil -relationship: inheres_in UBERON:0002373 ! palatine tonsil +intersection_of: RO:0000052 UBERON:0002373 ! inheres in palatine tonsil +relationship: RO:0000052 UBERON:0002373 ! inheres in palatine tonsil [Term] id: OBA:VT0002384 @@ -177354,7 +278505,7 @@ synonym: "morphology of pharyngeal tonsil" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0003705 ! tonsil morphology is_a: OBA:1000307 ! pharyngeal tonsil quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001732 ! pharyngeal tonsil +intersection_of: RO:0000052 UBERON:0001732 ! inheres in pharyngeal tonsil [Term] id: OBA:VT0002385 @@ -177364,7 +278515,7 @@ synonym: "morphology of lingual tonsil" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003705 ! tonsil morphology is_a: OBA:1000355 ! lingual tonsil quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007250 ! lingual tonsil +intersection_of: RO:0000052 UBERON:0007250 ! inheres in lingual tonsil [Term] id: OBA:VT0002386 @@ -177373,8 +278524,8 @@ def: "The morphology of a tubal tonsil." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of tubal tonsil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003705 ! tonsil morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003949 ! tubal tonsil -relationship: inheres_in UBERON:0003949 ! tubal tonsil +intersection_of: RO:0000052 UBERON:0003949 ! inheres in tubal tonsil +relationship: RO:0000052 UBERON:0003949 ! inheres in tubal tonsil [Term] id: OBA:VT0002388 @@ -177383,8 +278534,8 @@ def: "The morphology of a Peyer's patch epithelium." [AUTO:patterns/patterns/ent synonym: "morphology of Peyer's patch epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000488 ! intestinal epithelium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004693 ! Peyer's patch epithelium -relationship: inheres_in UBERON:0004693 ! Peyer's patch epithelium +intersection_of: RO:0000052 UBERON:0004693 ! inheres in Peyer's patch epithelium +relationship: RO:0000052 UBERON:0004693 ! inheres in Peyer's patch epithelium [Term] id: OBA:VT0002389 @@ -177394,8 +278545,8 @@ synonym: "morphology of Peyer's patch follicle" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010386 ! Peyer's patch follicle -relationship: inheres_in UBERON:0010386 ! Peyer's patch follicle +intersection_of: RO:0000052 UBERON:0010386 ! inheres in Peyer's patch follicle +relationship: RO:0000052 UBERON:0010386 ! inheres in Peyer's patch follicle [Term] id: OBA:VT0002391 @@ -177405,8 +278556,8 @@ synonym: "morphology of Peyer's patch germinal center" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004697 ! Peyer's patch germinal center -relationship: inheres_in UBERON:0004697 ! Peyer's patch germinal center +intersection_of: RO:0000052 UBERON:0004697 ! inheres in Peyer's patch germinal center +relationship: RO:0000052 UBERON:0004697 ! inheres in Peyer's patch germinal center [Term] id: OBA:VT0002393 @@ -177415,8 +278566,8 @@ def: "The morphology of a bronchial-associated lymphoid tissue." [AUTO:patterns/ synonym: "morphology of bronchial-associated lymphoid tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002377 ! mucosa-associated lymphoid tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001963 ! bronchial-associated lymphoid tissue -relationship: inheres_in UBERON:0001963 ! bronchial-associated lymphoid tissue +intersection_of: RO:0000052 UBERON:0001963 ! inheres in bronchial-associated lymphoid tissue +relationship: RO:0000052 UBERON:0001963 ! inheres in bronchial-associated lymphoid tissue [Term] id: OBA:VT0002398 @@ -177426,7 +278577,7 @@ synonym: "morphology of bone marrow cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000764 ! bone marrow cell quality is_a: OBA:VT0000716 ! immune system cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002092 ! bone marrow cell +intersection_of: RO:0000052 CL:0002092 ! inheres in bone marrow cell [Term] id: OBA:VT0002400 @@ -177435,8 +278586,8 @@ def: "The morphology of a multi fate stem cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of multi fate stem cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000048 ! multi fate stem cell -relationship: inheres_in CL:0000048 ! multi fate stem cell +intersection_of: RO:0000052 CL:0000048 ! inheres in multi fate stem cell +relationship: RO:0000052 CL:0000048 ! inheres in multi fate stem cell [Term] id: OBA:VT0002407 @@ -177445,8 +278596,8 @@ def: "The morphology of a double negative thymocyte." [AUTO:patterns/patterns/en synonym: "morphology of double negative thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002489 ! double negative thymocyte -relationship: inheres_in CL:0002489 ! double negative thymocyte +intersection_of: RO:0000052 CL:0002489 ! inheres in double negative thymocyte +relationship: RO:0000052 CL:0002489 ! inheres in double negative thymocyte [Term] id: OBA:VT0002414 @@ -177457,7 +278608,7 @@ is_a: OBA:0005896 ! myeloid cell morphology is_a: OBA:0005908 ! hematopoietic precursor cell morphology is_a: OBA:1000806 ! myeloblast quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000835 ! myeloblast +intersection_of: RO:0000052 CL:0000835 ! inheres in myeloblast [Term] id: OBA:VT0002416 @@ -177466,8 +278617,8 @@ def: "The morphology of a erythroblast." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of erythroblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005897 ! erythroid lineage cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000765 ! erythroblast -relationship: inheres_in CL:0000765 ! erythroblast +intersection_of: RO:0000052 CL:0000765 ! inheres in erythroblast +relationship: RO:0000052 CL:0000765 ! inheres in erythroblast [Term] id: OBA:VT0002419 @@ -177476,8 +278627,8 @@ def: "The quality of a innate immune response." [AUTO:patterns/patterns/entity_a synonym: "quality of innate immune response" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010139 ! immune response trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045087 ! innate immune response -relationship: inheres_in GO:0045087 ! innate immune response +intersection_of: RO:0000052 GO:0045087 ! inheres in innate immune response +relationship: RO:0000052 GO:0045087 ! inheres in innate immune response [Term] id: OBA:VT0002422 @@ -177486,8 +278637,8 @@ def: "The morphology of a basophil." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of basophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002441 ! granulocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000767 ! basophil -relationship: inheres_in CL:0000767 ! basophil +intersection_of: RO:0000052 CL:0000767 ! inheres in basophil +relationship: RO:0000052 CL:0000767 ! inheres in basophil [Term] id: OBA:VT0002423 @@ -177497,7 +278648,7 @@ synonym: "functionality of mast cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000179 ! mast cell quality is_a: OBA:VT0002442 ! leukocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000097 ! mast cell +intersection_of: RO:0000052 CL:0000097 ! inheres in mast cell [Term] id: OBA:VT0002424 @@ -177506,8 +278657,8 @@ def: "The morphology of a reticulocyte." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of reticulocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005897 ! erythroid lineage cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000558 ! reticulocyte -relationship: inheres_in CL:0000558 ! reticulocyte +intersection_of: RO:0000052 CL:0000558 ! inheres in reticulocyte +relationship: RO:0000052 CL:0000558 ! inheres in reticulocyte [Term] id: OBA:VT0002428 @@ -177517,8 +278668,8 @@ synonym: "morphology of semicircular canal" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001840 ! semicircular canal -relationship: inheres_in UBERON:0001840 ! semicircular canal +intersection_of: RO:0000052 UBERON:0001840 ! inheres in semicircular canal +relationship: RO:0000052 UBERON:0001840 ! inheres in semicircular canal [Term] id: OBA:VT0002429 @@ -177528,7 +278679,7 @@ synonym: "morphology of blood cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0005895 ! hematopoietic cell morphology is_a: OBA:1000866 ! blood cell quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000081 ! blood cell +intersection_of: RO:0000052 CL:0000081 ! inheres in blood cell [Term] id: OBA:VT0002433 @@ -177537,8 +278688,8 @@ def: "The morphology of a T-helper 1 cell." [AUTO:patterns/patterns/entity_attri synonym: "morphology of T-helper 1 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005014 ! CD4-positive helper T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000545 ! T-helper 1 cell -relationship: inheres_in CL:0000545 ! T-helper 1 cell +intersection_of: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell +relationship: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell [Term] id: OBA:VT0002434 @@ -177547,8 +278698,8 @@ def: "The morphology of a T-helper 2 cell." [AUTO:patterns/patterns/entity_attri synonym: "morphology of T-helper 2 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005014 ! CD4-positive helper T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000546 ! T-helper 2 cell -relationship: inheres_in CL:0000546 ! T-helper 2 cell +intersection_of: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell +relationship: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell [Term] id: OBA:VT0002435 @@ -177557,8 +278708,8 @@ def: "The morphology of a effector T cell." [AUTO:patterns/patterns/entity_attri synonym: "morphology of effector T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000911 ! effector T cell -relationship: inheres_in CL:0000911 ! effector T cell +intersection_of: RO:0000052 CL:0000911 ! inheres in effector T cell +relationship: RO:0000052 CL:0000911 ! inheres in effector T cell [Term] id: OBA:VT0002436 @@ -177567,8 +278718,8 @@ def: "The morphology of a CD8-positive, alpha-beta cytotoxic T cell." [AUTO:patt synonym: "morphology of CD8-positive, alpha-beta cytotoxic T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004117 ! CD8-positive, alpha-beta T cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000794 ! CD8-positive, alpha-beta cytotoxic T cell -relationship: inheres_in CL:0000794 ! CD8-positive, alpha-beta cytotoxic T cell +intersection_of: RO:0000052 CL:0000794 ! inheres in CD8-positive, alpha-beta cytotoxic T cell +relationship: RO:0000052 CL:0000794 ! inheres in CD8-positive, alpha-beta cytotoxic T cell [Term] id: OBA:VT0002439 @@ -177577,8 +278728,8 @@ def: "The morphology of a plasma cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of plasma cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002619 ! lymphocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000786 ! plasma cell -relationship: inheres_in CL:0000786 ! plasma cell +intersection_of: RO:0000052 CL:0000786 ! inheres in plasma cell +relationship: RO:0000052 CL:0000786 ! inheres in plasma cell [Term] id: OBA:VT0002440 @@ -177587,8 +278738,8 @@ def: "The morphology of a memory B cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of memory B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000787 ! memory B cell -relationship: inheres_in CL:0000787 ! memory B cell +intersection_of: RO:0000052 CL:0000787 ! inheres in memory B cell +relationship: RO:0000052 CL:0000787 ! inheres in memory B cell [Term] id: OBA:VT0002441 @@ -177598,8 +278749,8 @@ synonym: "morphology of granulocyte" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004339 ! myeloid leukocyte morphology is_a: OBA:VT0002429 ! blood cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000094 ! granulocyte -relationship: inheres_in CL:0000094 ! granulocyte +intersection_of: RO:0000052 CL:0000094 ! inheres in granulocyte +relationship: RO:0000052 CL:0000094 ! inheres in granulocyte [Term] id: OBA:VT0002442 @@ -177608,8 +278759,8 @@ def: "The functionality of a leukocyte." [AUTO:patterns/patterns/entity_attribut synonym: "functionality of leukocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000738 ! leukocyte -relationship: inheres_in CL:0000738 ! leukocyte +intersection_of: RO:0000052 CL:0000738 ! inheres in leukocyte +relationship: RO:0000052 CL:0000738 ! inheres in leukocyte [Term] id: OBA:VT0002444 @@ -177619,7 +278770,7 @@ synonym: "functionality of T cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000418 ! T cell quality is_a: OBA:VT0003945 ! lymphocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000084 ! T cell +intersection_of: RO:0000052 CL:0000084 ! inheres in T cell [Term] id: OBA:VT0002446 @@ -177630,8 +278781,8 @@ is_a: OBA:0004321 ! professional antigen presenting cell morphology is_a: OBA:0004339 ! myeloid leukocyte morphology is_a: OBA:VT0008251 ! phagocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000235 ! macrophage -relationship: inheres_in CL:0000235 ! macrophage +intersection_of: RO:0000052 CL:0000235 ! inheres in macrophage +relationship: RO:0000052 CL:0000235 ! inheres in macrophage [Term] id: OBA:VT0002447 @@ -177641,8 +278792,8 @@ synonym: "morphology of erythrocyte" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0005897 ! erythroid lineage cell morphology is_a: OBA:VT0002429 ! blood cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000232 ! erythrocyte -relationship: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte +relationship: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:VT0002451 @@ -177652,8 +278803,8 @@ synonym: "functionality of macrophage" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003714 ! professional antigen presenting cell functionality is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000235 ! macrophage -relationship: inheres_in CL:0000235 ! macrophage +intersection_of: RO:0000052 CL:0000235 ! inheres in macrophage +relationship: RO:0000052 CL:0000235 ! inheres in macrophage [Term] id: OBA:VT0002455 @@ -177671,7 +278822,7 @@ synonym: "has number of of B cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000574 ! B cell quality is_a: OBA:VT0000717 ! lymphocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000236 ! B cell +intersection_of: RO:0000052 CL:0000236 ! inheres in B cell [Term] id: OBA:VT0002459 @@ -177681,7 +278832,7 @@ synonym: "functionality of B cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000574 ! B cell quality is_a: OBA:VT0003945 ! lymphocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000236 ! B cell +intersection_of: RO:0000052 CL:0000236 ! inheres in B cell [Term] id: OBA:VT0002460 @@ -177691,8 +278842,8 @@ synonym: "amount of immunoglobulin complex" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0019814 ! immunoglobulin complex -relationship: inheres_in GO:0019814 ! immunoglobulin complex +intersection_of: RO:0000052 GO:0019814 ! inheres in immunoglobulin complex +relationship: RO:0000052 GO:0019814 ! inheres in immunoglobulin complex [Term] id: OBA:VT0002462 @@ -177703,8 +278854,8 @@ is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:1000866 ! blood cell quality is_a: OBA:VT0002442 ! leukocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000094 ! granulocyte -relationship: inheres_in CL:0000094 ! granulocyte +intersection_of: RO:0000052 CL:0000094 ! inheres in granulocyte +relationship: RO:0000052 CL:0000094 ! inheres in granulocyte [Term] id: OBA:VT0002463 @@ -177713,8 +278864,8 @@ def: "The functionality of a neutrophil." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of neutrophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002462 ! granulocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000775 ! neutrophil -relationship: inheres_in CL:0000775 ! neutrophil +intersection_of: RO:0000052 CL:0000775 ! inheres in neutrophil +relationship: RO:0000052 CL:0000775 ! inheres in neutrophil [Term] id: OBA:VT0002464 @@ -177723,8 +278874,8 @@ def: "The functionality of a basophil." [AUTO:patterns/patterns/entity_attribute synonym: "functionality of basophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002462 ! granulocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000767 ! basophil -relationship: inheres_in CL:0000767 ! basophil +intersection_of: RO:0000052 CL:0000767 ! inheres in basophil +relationship: RO:0000052 CL:0000767 ! inheres in basophil [Term] id: OBA:VT0002465 @@ -177733,8 +278884,8 @@ def: "The functionality of a eosinophil." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of eosinophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002462 ! granulocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000771 ! eosinophil -relationship: inheres_in CL:0000771 ! eosinophil +intersection_of: RO:0000052 CL:0000771 ! inheres in eosinophil +relationship: RO:0000052 CL:0000771 ! inheres in eosinophil [Term] id: OBA:VT0002504 @@ -177744,8 +278895,8 @@ synonym: "functionality of serotonin" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CHEBI:28790 ! serotonin -relationship: inheres_in CHEBI:28790 ! serotonin +intersection_of: RO:0000052 CHEBI:28790 ! inheres in serotonin +relationship: RO:0000052 CHEBI:28790 ! inheres in serotonin [Term] id: OBA:VT0002543 @@ -177755,7 +278906,7 @@ synonym: "length of phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002381 ! long bone length is_a: OBA:0002674 ! phalanx size intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003221 ! phalanx +intersection_of: RO:0000052 UBERON:0003221 ! inheres in phalanx [Term] id: OBA:VT0002544 @@ -177766,7 +278917,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002110 ! digit morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:VT0002551 @@ -177775,8 +278926,8 @@ def: "The quality of a blood coagulation." [AUTO:patterns/patterns/entity_attrib synonym: "quality of blood coagulation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000260 ! hemostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007596 ! blood coagulation -relationship: inheres_in GO:0007596 ! blood coagulation +intersection_of: RO:0000052 GO:0007596 ! inheres in blood coagulation +relationship: RO:0000052 GO:0007596 ! inheres in blood coagulation [Term] id: OBA:VT0002576 @@ -177785,8 +278936,8 @@ def: "The morphology of a enamel." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003889 ! odontoid tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001752 ! enamel -relationship: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel +relationship: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:VT0002579 @@ -177795,8 +278946,8 @@ def: "The morphology of a secondary lens fiber." [AUTO:patterns/patterns/entity_ synonym: "morphology of secondary lens fiber" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002225 ! secondary lens fiber -relationship: inheres_in CL:0002225 ! secondary lens fiber +intersection_of: RO:0000052 CL:0002225 ! inheres in secondary lens fiber +relationship: RO:0000052 CL:0002225 ! inheres in secondary lens fiber [Term] id: OBA:VT0002581 @@ -177806,8 +278957,8 @@ synonym: "morphology of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002116 ! ileum -relationship: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum +relationship: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:VT0002602 @@ -177816,8 +278967,8 @@ def: "The amount of a eosinophil." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of eosinophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003294 ! granulocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000771 ! eosinophil -relationship: inheres_in CL:0000771 ! eosinophil +intersection_of: RO:0000052 CL:0000771 ! inheres in eosinophil +relationship: RO:0000052 CL:0000771 ! inheres in eosinophil [Term] id: OBA:VT0002607 @@ -177826,8 +278977,8 @@ def: "The amount of a basophil." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of basophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003294 ! granulocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000767 ! basophil -relationship: inheres_in CL:0000767 ! basophil +intersection_of: RO:0000052 CL:0000767 ! inheres in basophil +relationship: RO:0000052 CL:0000767 ! inheres in basophil [Term] id: OBA:VT0002619 @@ -177836,8 +278987,8 @@ def: "The morphology of a lymphocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004338 ! mononuclear cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000542 ! lymphocyte -relationship: inheres_in CL:0000542 ! lymphocyte +intersection_of: RO:0000052 CL:0000542 ! inheres in lymphocyte +relationship: RO:0000052 CL:0000542 ! inheres in lymphocyte [Term] id: OBA:VT0002620 @@ -177847,8 +278998,8 @@ synonym: "morphology of monocyte" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004338 ! mononuclear cell morphology is_a: OBA:0004339 ! myeloid leukocyte morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000576 ! monocyte -relationship: inheres_in CL:0000576 ! monocyte +intersection_of: RO:0000052 CL:0000576 ! inheres in monocyte +relationship: RO:0000052 CL:0000576 ! inheres in monocyte [Term] id: OBA:VT0002622 @@ -177857,8 +279008,8 @@ def: "The morphology of a auditory hair cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of auditory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000045 ! hair cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000202 ! auditory hair cell -relationship: inheres_in CL:0000202 ! auditory hair cell +intersection_of: RO:0000052 CL:0000202 ! inheres in auditory hair cell +relationship: RO:0000052 CL:0000202 ! inheres in auditory hair cell [Term] id: OBA:VT0002623 @@ -177867,8 +279018,8 @@ def: "The morphology of a vestibular hair cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of vestibular hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000045 ! hair cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000609 ! vestibular hair cell -relationship: inheres_in CL:0000609 ! vestibular hair cell +intersection_of: RO:0000052 CL:0000609 ! inheres in vestibular hair cell +relationship: RO:0000052 CL:0000609 ! inheres in vestibular hair cell [Term] id: OBA:VT0002631 @@ -177878,8 +279029,8 @@ synonym: "morphology of epididymis" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001301 ! epididymis -relationship: inheres_in UBERON:0001301 ! epididymis +intersection_of: RO:0000052 UBERON:0001301 ! inheres in epididymis +relationship: RO:0000052 UBERON:0001301 ! inheres in epididymis [Term] id: OBA:VT0002637 @@ -177889,7 +279040,7 @@ synonym: "size of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001120 ! uterus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:VT0002641 @@ -177899,7 +279050,7 @@ synonym: "shape of erythrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000052 ! cell shape is_a: OBA:VT0002447 ! erythrocyte morphology trait intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:VT0002644 @@ -177917,7 +279068,7 @@ synonym: "delaminated of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002138 ! enamel structure is_a: PATO:0001514 ! delaminated intersection_of: PATO:0001514 ! delaminated -intersection_of: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:VT0002651 @@ -177927,7 +279078,7 @@ synonym: "morphology of sciatic nerve" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000790 ! sciatic nerve quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001322 ! sciatic nerve +intersection_of: RO:0000052 UBERON:0001322 ! inheres in sciatic nerve [Term] id: OBA:VT0002653 @@ -177937,8 +279088,8 @@ synonym: "morphology of ependyma" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004670 ! ependyma -relationship: inheres_in UBERON:0004670 ! ependyma +intersection_of: RO:0000052 UBERON:0004670 ! inheres in ependyma +relationship: RO:0000052 UBERON:0004670 ! inheres in ependyma [Term] id: OBA:VT0002655 @@ -177947,8 +279098,8 @@ def: "The morphology of a keratinocyte." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of keratinocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000312 ! keratinocyte -relationship: inheres_in CL:0000312 ! keratinocyte +intersection_of: RO:0000052 CL:0000312 ! inheres in keratinocyte +relationship: RO:0000052 CL:0000312 ! inheres in keratinocyte [Term] id: OBA:VT0002656 @@ -177957,8 +279108,8 @@ def: "The quality of a keratinocyte development." [AUTO:patterns/patterns/entity synonym: "quality of keratinocyte development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003334 ! keratinocyte development -relationship: inheres_in GO:0003334 ! keratinocyte development +intersection_of: RO:0000052 GO:0003334 ! inheres in keratinocyte development +relationship: RO:0000052 GO:0003334 ! inheres in keratinocyte development [Term] id: OBA:VT0002658 @@ -177967,8 +279118,8 @@ def: "The quality of a liver regeneration." [AUTO:patterns/patterns/entity_attri synonym: "quality of liver regeneration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000596 ! liver development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097421 ! liver regeneration -relationship: inheres_in GO:0097421 ! liver regeneration +intersection_of: RO:0000052 GO:0097421 ! inheres in liver regeneration +relationship: RO:0000052 GO:0097421 ! inheres in liver regeneration [Term] id: OBA:VT0002660 @@ -177978,8 +279129,8 @@ synonym: "morphology of caput epididymis" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004358 ! caput epididymis -relationship: inheres_in UBERON:0004358 ! caput epididymis +intersection_of: RO:0000052 UBERON:0004358 ! inheres in caput epididymis +relationship: RO:0000052 UBERON:0004358 ! inheres in caput epididymis [Term] id: OBA:VT0002661 @@ -177989,8 +279140,8 @@ synonym: "morphology of corpus epididymis" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004359 ! corpus epididymis -relationship: inheres_in UBERON:0004359 ! corpus epididymis +intersection_of: RO:0000052 UBERON:0004359 ! inheres in corpus epididymis +relationship: RO:0000052 UBERON:0004359 ! inheres in corpus epididymis [Term] id: OBA:VT0002662 @@ -178000,8 +279151,8 @@ synonym: "morphology of cauda epididymis" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004360 ! cauda epididymis -relationship: inheres_in UBERON:0004360 ! cauda epididymis +intersection_of: RO:0000052 UBERON:0004360 ! inheres in cauda epididymis +relationship: RO:0000052 UBERON:0004360 ! inheres in cauda epididymis [Term] id: OBA:VT0002664 @@ -178026,8 +279177,8 @@ synonym: "morphology of scrotum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001300 ! scrotum -relationship: inheres_in UBERON:0001300 ! scrotum +intersection_of: RO:0000052 UBERON:0001300 ! inheres in scrotum +relationship: RO:0000052 UBERON:0001300 ! inheres in scrotum [Term] id: OBA:VT0002673 @@ -178037,8 +279188,8 @@ synonym: "amount of sperm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003699 ! germ cell amount is_a: OBA:1000722 ! gamete quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000019 ! sperm -relationship: inheres_in CL:0000019 ! sperm +intersection_of: RO:0000052 CL:0000019 ! inheres in sperm +relationship: RO:0000052 CL:0000019 ! inheres in sperm [Term] id: OBA:VT0002674 @@ -178047,8 +279198,8 @@ def: "The quality of a flagellated sperm motility." [AUTO:patterns/patterns/enti synonym: "quality of flagellated sperm motility" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030317 ! flagellated sperm motility -relationship: inheres_in GO:0030317 ! flagellated sperm motility +intersection_of: RO:0000052 GO:0030317 ! inheres in flagellated sperm motility +relationship: RO:0000052 GO:0030317 ! inheres in flagellated sperm motility [Term] id: OBA:VT0002679 @@ -178058,8 +279209,8 @@ synonym: "morphology of corpus luteum" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0005808 ! female reproductive gland morphology is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002512 ! corpus luteum -relationship: inheres_in UBERON:0002512 ! corpus luteum +intersection_of: RO:0000052 UBERON:0002512 ! inheres in corpus luteum +relationship: RO:0000052 UBERON:0002512 ! inheres in corpus luteum [Term] id: OBA:VT0002680 @@ -178069,8 +279220,8 @@ synonym: "amount of corpus luteum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002512 ! corpus luteum -relationship: inheres_in UBERON:0002512 ! corpus luteum +intersection_of: RO:0000052 UBERON:0002512 ! inheres in corpus luteum +relationship: RO:0000052 UBERON:0002512 ! inheres in corpus luteum [Term] id: OBA:VT0002682 @@ -178079,8 +279230,8 @@ def: "The amount of a mature ovarian follicle." [AUTO:patterns/patterns/entity_a synonym: "amount of mature ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004516 ! ovarian follicle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0003982 ! mature ovarian follicle -relationship: inheres_in UBERON:0003982 ! mature ovarian follicle +intersection_of: RO:0000052 UBERON:0003982 ! inheres in mature ovarian follicle +relationship: RO:0000052 UBERON:0003982 ! inheres in mature ovarian follicle [Term] id: OBA:VT0002689 @@ -178090,7 +279241,7 @@ synonym: "morphology of molar tooth" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000436 ! molar tooth quality is_a: OBA:VT0002100 ! tooth morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003655 ! molar tooth +intersection_of: RO:0000052 UBERON:0003655 ! inheres in molar tooth [Term] id: OBA:VT0002693 @@ -178100,8 +279251,8 @@ synonym: "functionality of pancreas" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001264 ! pancreas -relationship: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas +relationship: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:VT0002694 @@ -178111,8 +279262,8 @@ synonym: "aggregated of pancreas secretion" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001629 ! aggregated intersection_of: PATO:0001629 ! aggregated -intersection_of: inheres_in UBERON:0004795 ! pancreas secretion -relationship: inheres_in UBERON:0004795 ! pancreas secretion +intersection_of: RO:0000052 UBERON:0004795 ! inheres in pancreas secretion +relationship: RO:0000052 UBERON:0004795 ! inheres in pancreas secretion [Term] id: OBA:VT0002695 @@ -178130,7 +279281,7 @@ synonym: "size of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002092 ! eye morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:VT0002698 @@ -178140,8 +279291,8 @@ synonym: "morphology of sclera" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001773 ! sclera -relationship: inheres_in UBERON:0001773 ! sclera +intersection_of: RO:0000052 UBERON:0001773 ! inheres in sclera +relationship: RO:0000052 UBERON:0001773 ! inheres in sclera [Term] id: OBA:VT0002699 @@ -178151,7 +279302,7 @@ synonym: "morphology of vitreous body" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000686 ! vitreous body quality is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001798 ! vitreous body +intersection_of: RO:0000052 UBERON:0001798 ! inheres in vitreous body [Term] id: OBA:VT0002703 @@ -178160,8 +279311,8 @@ def: "The morphology of a nephron tubule." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of nephron tubule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001231 ! nephron tubule -relationship: inheres_in UBERON:0001231 ! nephron tubule +intersection_of: RO:0000052 UBERON:0001231 ! inheres in nephron tubule +relationship: RO:0000052 UBERON:0001231 ! inheres in nephron tubule [Term] id: OBA:VT0002705 @@ -178172,7 +279323,7 @@ is_a: OBA:0000172 ! tube size is_a: OBA:0004106 ! kidney epithelium size is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001231 ! nephron tubule +intersection_of: RO:0000052 UBERON:0001231 ! inheres in nephron tubule [Term] id: OBA:VT0002706 @@ -178182,7 +279333,7 @@ synonym: "size of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002135 ! kidney morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:VT0002707 @@ -178192,8 +279343,8 @@ synonym: "mass of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002113 ! kidney -relationship: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney +relationship: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:VT0002713 @@ -178202,8 +279353,8 @@ def: "The quality of a glycogen catabolic process." [AUTO:patterns/patterns/enti synonym: "quality of glycogen catabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000247 ! polysaccharide metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0005980 ! glycogen catabolic process -relationship: inheres_in GO:0005980 ! glycogen catabolic process +intersection_of: RO:0000052 GO:0005980 ! inheres in glycogen catabolic process +relationship: RO:0000052 GO:0005980 ! inheres in glycogen catabolic process [Term] id: OBA:VT0002716 @@ -178214,7 +279365,7 @@ is_a: OBA:VT0000652 ! sebaceous gland size trait is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0002717 ! preputial gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000359 ! preputial gland +intersection_of: RO:0000052 UBERON:0000359 ! inheres in preputial gland [Term] id: OBA:VT0002717 @@ -178224,8 +279375,8 @@ synonym: "morphology of preputial gland" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000647 ! sebaceous gland morphology trait is_a: OBA:VT0000653 ! sex gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000359 ! preputial gland -relationship: inheres_in UBERON:0000359 ! preputial gland +intersection_of: RO:0000052 UBERON:0000359 ! inheres in preputial gland +relationship: RO:0000052 UBERON:0000359 ! inheres in preputial gland [Term] id: OBA:VT0002718 @@ -178235,8 +279386,8 @@ synonym: "morphology of inner cell mass" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000087 ! inner cell mass -relationship: inheres_in UBERON:0000087 ! inner cell mass +intersection_of: RO:0000052 UBERON:0000087 ! inheres in inner cell mass +relationship: RO:0000052 UBERON:0000087 ! inheres in inner cell mass [Term] id: OBA:VT0002722 @@ -178246,8 +279397,8 @@ synonym: "morphology of immune organ" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005057 ! immune organ -relationship: inheres_in UBERON:0005057 ! immune organ +intersection_of: RO:0000052 UBERON:0005057 ! inheres in immune organ +relationship: RO:0000052 UBERON:0005057 ! inheres in immune organ [Term] id: OBA:VT0002725 @@ -178257,7 +279408,7 @@ synonym: "morphology of vein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000292 ! vein quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001638 ! vein +intersection_of: RO:0000052 UBERON:0001638 ! inheres in vein [Term] id: OBA:VT0002726 @@ -178267,7 +279418,7 @@ synonym: "morphology of pulmonary vein" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000485 ! pulmonary vein quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002016 ! pulmonary vein +intersection_of: RO:0000052 UBERON:0002016 ! inheres in pulmonary vein [Term] id: OBA:VT0002729 @@ -178277,8 +279428,8 @@ synonym: "morphology of inner ear canal" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003950 ! inner ear canal -relationship: inheres_in UBERON:0003950 ! inner ear canal +intersection_of: RO:0000052 UBERON:0003950 ! inheres in inner ear canal +relationship: RO:0000052 UBERON:0003950 ! inheres in inner ear canal [Term] id: OBA:VT0002731 @@ -178288,7 +279439,7 @@ synonym: "size of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000495 ! colon morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:VT0002733 @@ -178297,8 +279448,8 @@ def: "The quality of a detection of temperature stimulus involved in sensory per synonym: "quality of detection of temperature stimulus involved in sensory perception of pain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050965 ! detection of temperature stimulus involved in sensory perception of pain -relationship: inheres_in GO:0050965 ! detection of temperature stimulus involved in sensory perception of pain +intersection_of: RO:0000052 GO:0050965 ! inheres in detection of temperature stimulus involved in sensory perception of pain +relationship: RO:0000052 GO:0050965 ! inheres in detection of temperature stimulus involved in sensory perception of pain [Term] id: OBA:VT0002734 @@ -178307,8 +279458,8 @@ def: "The quality of a detection of mechanical stimulus involved in sensory perc synonym: "quality of detection of mechanical stimulus involved in sensory perception of pain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050966 ! detection of mechanical stimulus involved in sensory perception of pain -relationship: inheres_in GO:0050966 ! detection of mechanical stimulus involved in sensory perception of pain +intersection_of: RO:0000052 GO:0050966 ! inheres in detection of mechanical stimulus involved in sensory perception of pain +relationship: RO:0000052 GO:0050966 ! inheres in detection of mechanical stimulus involved in sensory perception of pain [Term] id: OBA:VT0002735 @@ -178317,8 +279468,8 @@ def: "The quality of a detection of chemical stimulus involved in sensory percep synonym: "quality of detection of chemical stimulus involved in sensory perception of pain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050968 ! detection of chemical stimulus involved in sensory perception of pain -relationship: inheres_in GO:0050968 ! detection of chemical stimulus involved in sensory perception of pain +intersection_of: RO:0000052 GO:0050968 ! inheres in detection of chemical stimulus involved in sensory perception of pain +relationship: RO:0000052 GO:0050968 ! inheres in detection of chemical stimulus involved in sensory perception of pain [Term] id: OBA:VT0002739 @@ -178327,8 +279478,8 @@ def: "The quality of a olfactory bulb development." [AUTO:patterns/patterns/enti synonym: "quality of olfactory bulb development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021772 ! olfactory bulb development -relationship: inheres_in GO:0021772 ! olfactory bulb development +intersection_of: RO:0000052 GO:0021772 ! inheres in olfactory bulb development +relationship: RO:0000052 GO:0021772 ! inheres in olfactory bulb development [Term] id: OBA:VT0002741 @@ -178338,7 +279489,7 @@ synonym: "size of olfactory bulb" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000819 ! olfactory bulb morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002264 ! olfactory bulb +intersection_of: RO:0000052 UBERON:0002264 ! inheres in olfactory bulb [Term] id: OBA:VT0002742 @@ -178348,7 +279499,7 @@ synonym: "size of submandibular lymph node" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0009627 ! submandibular lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002520 ! submandibular lymph node +intersection_of: RO:0000052 UBERON:0002520 ! inheres in submandibular lymph node [Term] id: OBA:VT0002746 @@ -178357,8 +279508,8 @@ def: "The morphology of a semi-lunar valve." [AUTO:patterns/patterns/entity_attr synonym: "morphology of semi-lunar valve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003469 ! cardial valve morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005623 ! semi-lunar valve -relationship: inheres_in UBERON:0005623 ! semi-lunar valve +intersection_of: RO:0000052 UBERON:0005623 ! inheres in semi-lunar valve +relationship: RO:0000052 UBERON:0005623 ! inheres in semi-lunar valve [Term] id: OBA:VT0002751 @@ -178368,8 +279519,8 @@ synonym: "morphology of autonomic nervous system" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002410 ! autonomic nervous system -relationship: inheres_in UBERON:0002410 ! autonomic nervous system +intersection_of: RO:0000052 UBERON:0002410 ! inheres in autonomic nervous system +relationship: RO:0000052 UBERON:0002410 ! inheres in autonomic nervous system [Term] id: OBA:VT0002752 @@ -178379,7 +279530,7 @@ synonym: "morphology of somatic nervous system" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000193 ! somatic nervous system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000012 ! somatic nervous system +intersection_of: RO:0000052 UBERON:0000012 ! inheres in somatic nervous system [Term] id: OBA:VT0002753 @@ -178389,7 +279540,7 @@ synonym: "size of heart left ventricle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0003921 ! left ventricle morphology trait is_a: OBA:VT0010298 ! heart ventricle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:VT0002754 @@ -178399,7 +279550,7 @@ synonym: "size of heart right ventricle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0003920 ! right ventricle morphology trait is_a: OBA:VT0010298 ! heart ventricle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:VT0002758 @@ -178409,7 +279560,7 @@ synonym: "length of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003456 ! tail size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:VT0002759 @@ -178418,8 +279569,8 @@ def: "The morphology of a caudal vertebra." [AUTO:patterns/patterns/entity_attri synonym: "morphology of caudal vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001095 ! caudal vertebra -relationship: inheres_in UBERON:0001095 ! caudal vertebra +intersection_of: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra +relationship: RO:0000052 UBERON:0001095 ! inheres in caudal vertebra [Term] id: OBA:VT0002761 @@ -178428,8 +279579,8 @@ def: "The morphology of a hippocampal mossy fiber." [AUTO:patterns/patterns/enti synonym: "morphology of hippocampal mossy fiber" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005404 ! axon morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0097457 ! hippocampal mossy fiber -relationship: inheres_in GO:0097457 ! hippocampal mossy fiber +intersection_of: RO:0000052 GO:0097457 ! inheres in hippocampal mossy fiber +relationship: RO:0000052 GO:0097457 ! inheres in hippocampal mossy fiber [Term] id: OBA:VT0002769 @@ -178439,8 +279590,8 @@ synonym: "morphology of vas deferens" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001000 ! vas deferens -relationship: inheres_in UBERON:0001000 ! vas deferens +intersection_of: RO:0000052 UBERON:0001000 ! inheres in vas deferens +relationship: RO:0000052 UBERON:0001000 ! inheres in vas deferens [Term] id: OBA:VT0002784 @@ -178449,8 +279600,8 @@ def: "The morphology of a Sertoli cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of Sertoli cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000216 ! Sertoli cell -relationship: inheres_in CL:0000216 ! Sertoli cell +intersection_of: RO:0000052 CL:0000216 ! inheres in Sertoli cell +relationship: RO:0000052 CL:0000216 ! inheres in Sertoli cell [Term] id: OBA:VT0002785 @@ -178460,7 +279611,7 @@ synonym: "has number of of Leydig cell" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000182 ! Leydig cell quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000178 ! Leydig cell +intersection_of: RO:0000052 CL:0000178 ! inheres in Leydig cell [Term] id: OBA:VT0002786 @@ -178470,7 +279621,7 @@ synonym: "morphology of Leydig cell" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000182 ! Leydig cell quality is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000178 ! Leydig cell +intersection_of: RO:0000052 CL:0000178 ! inheres in Leydig cell [Term] id: OBA:VT0002792 @@ -178480,8 +279631,8 @@ synonym: "morphology of retina blood vessel" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003501 ! retina blood vessel -relationship: inheres_in UBERON:0003501 ! retina blood vessel +intersection_of: RO:0000052 UBERON:0003501 ! inheres in retina blood vessel +relationship: RO:0000052 UBERON:0003501 ! inheres in retina blood vessel [Term] id: OBA:VT0002796 @@ -178491,8 +279642,8 @@ synonym: "quality of regulation of water loss via skin" EXACT [AUTO:patterns/pat is_a: OBA:VT0001784 ! fluid regulation trait is_a: OBA:VT0015077 ! molecule homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033561 ! regulation of water loss via skin -relationship: inheres_in GO:0033561 ! regulation of water loss via skin +intersection_of: RO:0000052 GO:0033561 ! inheres in regulation of water loss via skin +relationship: RO:0000052 GO:0033561 ! inheres in regulation of water loss via skin [Term] id: OBA:VT0002809 @@ -178502,7 +279653,7 @@ synonym: "size of spinal cord" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000955 ! spinal cord morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002240 ! spinal cord +intersection_of: RO:0000052 UBERON:0002240 ! inheres in spinal cord [Term] id: OBA:VT0002817 @@ -178511,8 +279662,8 @@ def: "The quality of a tooth mineralization." [AUTO:patterns/patterns/entity_att synonym: "quality of tooth mineralization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0034505 ! tooth mineralization -relationship: inheres_in GO:0034505 ! tooth mineralization +intersection_of: RO:0000052 GO:0034505 ! inheres in tooth mineralization +relationship: RO:0000052 GO:0034505 ! inheres in tooth mineralization [Term] id: OBA:VT0002818 @@ -178521,8 +279672,8 @@ def: "The morphology of a dentine." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of dentine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003889 ! odontoid tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001751 ! dentine -relationship: inheres_in UBERON:0001751 ! dentine +intersection_of: RO:0000052 UBERON:0001751 ! inheres in dentine +relationship: RO:0000052 UBERON:0001751 ! inheres in dentine [Term] id: OBA:VT0002819 @@ -178532,8 +279683,8 @@ synonym: "morphology of tooth cavity" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002487 ! tooth cavity -relationship: inheres_in UBERON:0002487 ! tooth cavity +intersection_of: RO:0000052 UBERON:0002487 ! inheres in tooth cavity +relationship: RO:0000052 UBERON:0002487 ! inheres in tooth cavity [Term] id: OBA:VT0002820 @@ -178544,7 +279695,7 @@ is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000377 ! premaxilla quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002244 ! premaxilla +intersection_of: RO:0000052 UBERON:0002244 ! inheres in premaxilla [Term] id: OBA:VT0002825 @@ -178554,8 +279705,8 @@ synonym: "morphology of notochord" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002328 ! notochord -relationship: inheres_in UBERON:0002328 ! notochord +intersection_of: RO:0000052 UBERON:0002328 ! inheres in notochord +relationship: RO:0000052 UBERON:0002328 ! inheres in notochord [Term] id: OBA:VT0002827 @@ -178565,8 +279716,8 @@ synonym: "morphology of renal corpuscle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001229 ! renal corpuscle -relationship: inheres_in UBERON:0001229 ! renal corpuscle +intersection_of: RO:0000052 UBERON:0001229 ! inheres in renal corpuscle +relationship: RO:0000052 UBERON:0001229 ! inheres in renal corpuscle [Term] id: OBA:VT0002828 @@ -178576,8 +279727,8 @@ synonym: "morphology of glomerular capsule" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001230 ! glomerular capsule -relationship: inheres_in UBERON:0001230 ! glomerular capsule +intersection_of: RO:0000052 UBERON:0001230 ! inheres in glomerular capsule +relationship: RO:0000052 UBERON:0001230 ! inheres in glomerular capsule [Term] id: OBA:VT0002829 @@ -178587,7 +279738,7 @@ synonym: "morphology of juxtaglomerular apparatus" EXACT [AUTO:patterns/patterns is_a: OBA:1000930 ! juxtaglomerular apparatus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002303 ! juxtaglomerular apparatus +intersection_of: RO:0000052 UBERON:0002303 ! inheres in juxtaglomerular apparatus [Term] id: OBA:VT0002835 @@ -178597,7 +279748,7 @@ synonym: "morphology of cranial suture" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003754 ! skeletal joint morphology is_a: OBA:1000211 ! cranial suture quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003685 ! cranial suture +intersection_of: RO:0000052 UBERON:0003685 ! inheres in cranial suture [Term] id: OBA:VT0002836 @@ -178607,8 +279758,8 @@ synonym: "morphology of chorion membrane" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003124 ! chorion membrane -relationship: inheres_in UBERON:0003124 ! chorion membrane +intersection_of: RO:0000052 UBERON:0003124 ! inheres in chorion membrane +relationship: RO:0000052 UBERON:0003124 ! inheres in chorion membrane [Term] id: OBA:VT0002840 @@ -178618,8 +279769,8 @@ synonym: "morphology of lens fiber" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002444 ! lens fiber -relationship: inheres_in UBERON:0002444 ! lens fiber +intersection_of: RO:0000052 UBERON:0002444 ! inheres in lens fiber +relationship: RO:0000052 UBERON:0002444 ! inheres in lens fiber [Term] id: OBA:VT0002845 @@ -178629,8 +279780,8 @@ synonym: "mass of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000947 ! aorta -relationship: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta +relationship: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:VT0002846 @@ -178640,7 +279791,7 @@ synonym: "volume of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0007090 ! aorta size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:VT0002847 @@ -178650,7 +279801,7 @@ synonym: "proportionality to of glomerular filtration" EXACT [AUTO:patterns/patt is_a: OBA:1000888 ! glomerular filtration quality is_a: PATO:0001470 ! proportionality to intersection_of: PATO:0001470 ! proportionality to -intersection_of: inheres_in GO:0003094 ! glomerular filtration +intersection_of: RO:0000052 GO:0003094 ! inheres in glomerular filtration [Term] id: OBA:VT0002851 @@ -178667,8 +279818,8 @@ def: "The morphology of a vestibulocochlear ganglion." [AUTO:patterns/patterns/e synonym: "morphology of vestibulocochlear ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002827 ! vestibulocochlear ganglion -relationship: inheres_in UBERON:0002827 ! vestibulocochlear ganglion +intersection_of: RO:0000052 UBERON:0002827 ! inheres in vestibulocochlear ganglion +relationship: RO:0000052 UBERON:0002827 ! inheres in vestibulocochlear ganglion [Term] id: OBA:VT0002856 @@ -178679,8 +279830,8 @@ is_a: OBA:1000531 ! ganglion of peripheral nervous system quality is_a: OBA:VT0000960 ! sensory ganglion morphology trait is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002824 ! vestibular ganglion -relationship: inheres_in UBERON:0002824 ! vestibular ganglion +intersection_of: RO:0000052 UBERON:0002824 ! inheres in vestibular ganglion +relationship: RO:0000052 UBERON:0002824 ! inheres in vestibular ganglion [Term] id: OBA:VT0002858 @@ -178690,7 +279841,7 @@ synonym: "morphology of posterior semicircular canal" EXACT [AUTO:patterns/patte is_a: OBA:1000780 ! posterior semicircular canal quality is_a: OBA:VT0002428 ! semicircular canal morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001842 ! posterior semicircular canal +intersection_of: RO:0000052 UBERON:0001842 ! inheres in posterior semicircular canal [Term] id: OBA:VT0002861 @@ -178700,8 +279851,8 @@ synonym: "morphology of post-anal tail bud" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002533 ! post-anal tail bud -relationship: inheres_in UBERON:0002533 ! post-anal tail bud +intersection_of: RO:0000052 UBERON:0002533 ! inheres in post-anal tail bud +relationship: RO:0000052 UBERON:0002533 ! inheres in post-anal tail bud [Term] id: OBA:VT0002864 @@ -178711,7 +279862,7 @@ synonym: "morphology of ocular fundus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000281 ! ocular fundus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003951 ! ocular fundus +intersection_of: RO:0000052 UBERON:0003951 ! inheres in ocular fundus [Term] id: OBA:VT0002876 @@ -178720,8 +279871,8 @@ def: "The functionality of a thyroid gland." [AUTO:patterns/patterns/entity_attr synonym: "functionality of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005865 ! endocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002046 ! thyroid gland -relationship: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland +relationship: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:VT0002878 @@ -178731,7 +279882,7 @@ synonym: "morphology of corticospinal tract" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000490 ! corticospinal tract quality is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002707 ! corticospinal tract +intersection_of: RO:0000052 UBERON:0002707 ! inheres in corticospinal tract [Term] id: OBA:VT0002882 @@ -178740,8 +279891,8 @@ def: "The morphology of a neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000540 ! neuron -relationship: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron +relationship: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:VT0002894 @@ -178751,8 +279902,8 @@ synonym: "morphology of otolith" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002280 ! otolith -relationship: inheres_in UBERON:0002280 ! otolith +intersection_of: RO:0000052 UBERON:0002280 ! inheres in otolith +relationship: RO:0000052 UBERON:0002280 ! inheres in otolith [Term] id: OBA:VT0002895 @@ -178762,7 +279913,7 @@ synonym: "morphology of otolithic part of statoconial membrane" EXACT [AUTO:patt is_a: OBA:1000831 ! otolithic part of statoconial membrane quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002519 ! otolithic part of statoconial membrane +intersection_of: RO:0000052 UBERON:0002519 ! inheres in otolithic part of statoconial membrane [Term] id: OBA:VT0002896 @@ -178771,8 +279922,8 @@ def: "The quality of a bone mineralization." [AUTO:patterns/patterns/entity_attr synonym: "quality of bone mineralization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030282 ! bone mineralization -relationship: inheres_in GO:0030282 ! bone mineralization +intersection_of: RO:0000052 GO:0030282 ! inheres in bone mineralization +relationship: RO:0000052 GO:0030282 ! inheres in bone mineralization [Term] id: OBA:VT0002900 @@ -178796,8 +279947,8 @@ def: "The quality of a parturition." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of parturition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007567 ! parturition -relationship: inheres_in GO:0007567 ! parturition +intersection_of: RO:0000052 GO:0007567 ! inheres in parturition +relationship: RO:0000052 GO:0007567 ! inheres in parturition [Term] id: OBA:VT0002909 @@ -178806,8 +279957,8 @@ def: "The functionality of a adrenal gland." [AUTO:patterns/patterns/entity_attr synonym: "functionality of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005865 ! endocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002369 ! adrenal gland -relationship: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland +relationship: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:VT0002918 @@ -178817,8 +279968,8 @@ synonym: "aggregated of 2,5-diphenylfuran" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0001629 ! aggregated intersection_of: PATO:0001629 ! aggregated -intersection_of: inheres_in CHEBI:50459 ! 2,5-diphenylfuran -relationship: inheres_in CHEBI:50459 ! 2,5-diphenylfuran +intersection_of: RO:0000052 CHEBI:50459 ! inheres in 2,5-diphenylfuran +relationship: RO:0000052 CHEBI:50459 ! inheres in 2,5-diphenylfuran [Term] id: OBA:VT0002928 @@ -178828,8 +279979,8 @@ synonym: "morphology of bile duct" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002394 ! bile duct -relationship: inheres_in UBERON:0002394 ! bile duct +intersection_of: RO:0000052 UBERON:0002394 ! inheres in bile duct +relationship: RO:0000052 UBERON:0002394 ! inheres in bile duct [Term] id: OBA:VT0002929 @@ -178838,8 +279989,8 @@ def: "The quality of a common bile duct development." [AUTO:patterns/patterns/en synonym: "quality of common bile duct development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061009 ! common bile duct development -relationship: inheres_in GO:0061009 ! common bile duct development +intersection_of: RO:0000052 GO:0061009 ! inheres in common bile duct development +relationship: RO:0000052 GO:0061009 ! inheres in common bile duct development [Term] id: OBA:VT0002932 @@ -178849,8 +280000,8 @@ synonym: "morphology of articulation" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004905 ! articulation -relationship: inheres_in UBERON:0004905 ! articulation +intersection_of: RO:0000052 UBERON:0004905 ! inheres in articulation +relationship: RO:0000052 UBERON:0004905 ! inheres in articulation [Term] id: OBA:VT0002949 @@ -178859,8 +280010,8 @@ def: "The quality of a neural crest cell development." [AUTO:patterns/patterns/e synonym: "quality of neural crest cell development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0014032 ! neural crest cell development -relationship: inheres_in GO:0014032 ! neural crest cell development +intersection_of: RO:0000052 GO:0014032 ! inheres in neural crest cell development +relationship: RO:0000052 GO:0014032 ! inheres in neural crest cell development [Term] id: OBA:VT0002950 @@ -178869,8 +280020,8 @@ def: "The quality of a neural crest cell migration." [AUTO:patterns/patterns/ent synonym: "quality of neural crest cell migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001755 ! neural crest cell migration -relationship: inheres_in GO:0001755 ! neural crest cell migration +intersection_of: RO:0000052 GO:0001755 ! inheres in neural crest cell migration +relationship: RO:0000052 GO:0001755 ! inheres in neural crest cell migration [Term] id: OBA:VT0002961 @@ -178879,8 +280030,8 @@ def: "The quality of a axon guidance." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of axon guidance" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007411 ! axon guidance -relationship: inheres_in GO:0007411 ! axon guidance +intersection_of: RO:0000052 GO:0007411 ! inheres in axon guidance +relationship: RO:0000052 GO:0007411 ! inheres in axon guidance [Term] id: OBA:VT0002970 @@ -178889,8 +280040,8 @@ def: "The morphology of a white adipose tissue." [AUTO:patterns/patterns/entity_ synonym: "morphology of white adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000003 ! adipose morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001347 ! white adipose tissue -relationship: inheres_in UBERON:0001347 ! white adipose tissue +intersection_of: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue +relationship: RO:0000052 UBERON:0001347 ! inheres in white adipose tissue [Term] id: OBA:VT0002971 @@ -178899,8 +280050,8 @@ def: "The morphology of a brown adipose tissue." [AUTO:patterns/patterns/entity_ synonym: "morphology of brown adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000003 ! adipose morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001348 ! brown adipose tissue -relationship: inheres_in UBERON:0001348 ! brown adipose tissue +intersection_of: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue +relationship: RO:0000052 UBERON:0001348 ! inheres in brown adipose tissue [Term] id: OBA:VT0002975 @@ -178910,7 +280061,7 @@ synonym: "size of blood vessel smooth muscle" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005592 ! blood vessel smooth muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004237 ! blood vessel smooth muscle +intersection_of: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle [Term] id: OBA:VT0002982 @@ -178919,8 +280070,8 @@ def: "The quality of a germ cell migration." [AUTO:patterns/patterns/entity_attr synonym: "quality of germ cell migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008354 ! germ cell migration -relationship: inheres_in GO:0008354 ! germ cell migration +intersection_of: RO:0000052 GO:0008354 ! inheres in germ cell migration +relationship: RO:0000052 GO:0008354 ! inheres in germ cell migration [Term] id: OBA:VT0002983 @@ -178930,8 +280081,8 @@ synonym: "has number of of retinal ganglion cell" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000740 ! retinal ganglion cell -relationship: inheres_in CL:0000740 ! retinal ganglion cell +intersection_of: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell +relationship: RO:0000052 CL:0000740 ! inheres in retinal ganglion cell [Term] id: OBA:VT0002985 @@ -178948,7 +280099,7 @@ synonym: "osmolarity of urine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000056 ! urine trait is_a: PATO:0001655 ! osmolarity intersection_of: PATO:0001655 ! osmolarity -intersection_of: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:VT0002990 @@ -178958,7 +280109,7 @@ synonym: "length of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003585 ! ureter size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0002991 @@ -178968,8 +280119,8 @@ synonym: "functionality of sebaceous gland" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0005150 ! integumentary adnexa functionality is_a: OBA:0005860 ! holocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001821 ! sebaceous gland -relationship: inheres_in UBERON:0001821 ! sebaceous gland +intersection_of: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland +relationship: RO:0000052 UBERON:0001821 ! inheres in sebaceous gland [Term] id: OBA:VT0002997 @@ -178979,7 +280130,7 @@ synonym: "size of seminal vesicle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0002059 ! seminal gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000998 ! seminal vesicle +intersection_of: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle [Term] id: OBA:VT0002998 @@ -178988,8 +280139,8 @@ def: "The quality of a bone remodeling." [AUTO:patterns/patterns/entity_attribut synonym: "quality of bone remodeling" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0046849 ! bone remodeling -relationship: inheres_in GO:0046849 ! bone remodeling +intersection_of: RO:0000052 GO:0046849 ! inheres in bone remodeling +relationship: RO:0000052 GO:0046849 ! inheres in bone remodeling [Term] id: OBA:VT0003005 @@ -178999,7 +280150,7 @@ synonym: "morphology of hippocampus fimbria" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000914 ! hippocampus fimbria quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002310 ! hippocampus fimbria +intersection_of: RO:0000052 UBERON:0002310 ! inheres in hippocampus fimbria [Term] id: OBA:VT0003006 @@ -179009,7 +280160,7 @@ synonym: "morphology of fornix of brain" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000738 ! fornix of brain quality is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000052 ! fornix of brain +intersection_of: RO:0000052 UBERON:0000052 ! inheres in fornix of brain [Term] id: OBA:VT0003009 @@ -179018,8 +280169,8 @@ def: "The quality of a http://purl.obolibrary.org/obo/GO_0050663." [AUTO:pattern synonym: "quality of http://purl.obolibrary.org/obo/GO_0050663" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050663 -relationship: inheres_in GO:0050663 +intersection_of: RO:0000052 GO:0050663 ! inheres in +relationship: RO:0000052 GO:0050663 ! inheres in [Term] id: OBA:VT0003014 @@ -179029,8 +280180,8 @@ synonym: "morphology of renal medulla" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000362 ! renal medulla -relationship: inheres_in UBERON:0000362 ! renal medulla +intersection_of: RO:0000052 UBERON:0000362 ! inheres in renal medulla +relationship: RO:0000052 UBERON:0000362 ! inheres in renal medulla [Term] id: OBA:VT0003015 @@ -179046,6 +280197,7 @@ name: blood chloride amount def: "The amount of a chloride when measured in blood." [AUTO:patterns/patterns/entity_attribute_location] synonym: "blood chloride amount" EXACT [AUTO:patterns/patterns/entity_attribute_location] is_a: OBA:1000959 ! chloride amount +is_a: OBA:VT0000068 ! blood mineral amount [Term] id: OBA:VT0003047 @@ -179054,8 +280206,8 @@ def: "The morphology of a thoracic vertebra." [AUTO:patterns/patterns/entity_att synonym: "morphology of thoracic vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002347 ! thoracic vertebra -relationship: inheres_in UBERON:0002347 ! thoracic vertebra +intersection_of: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra +relationship: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra [Term] id: OBA:VT0003051 @@ -179065,7 +280217,7 @@ synonym: "shape of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002111 ! tail morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:VT0003055 @@ -179074,8 +280226,8 @@ def: "The morphology of a epiphyseal plate." [AUTO:patterns/patterns/entity_attr synonym: "morphology of epiphyseal plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004268 ! hyaline cartilage tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002516 ! epiphyseal plate -relationship: inheres_in UBERON:0002516 ! epiphyseal plate +intersection_of: RO:0000052 UBERON:0002516 ! inheres in epiphyseal plate +relationship: RO:0000052 UBERON:0002516 ! inheres in epiphyseal plate [Term] id: OBA:VT0003056 @@ -179084,8 +280236,8 @@ def: "The morphology of a hyoid bone." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hyoid bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001685 ! hyoid bone -relationship: inheres_in UBERON:0001685 ! hyoid bone +intersection_of: RO:0000052 UBERON:0001685 ! inheres in hyoid bone +relationship: RO:0000052 UBERON:0001685 ! inheres in hyoid bone [Term] id: OBA:VT0003057 @@ -179095,8 +280247,8 @@ synonym: "morphology of epicardium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002348 ! epicardium -relationship: inheres_in UBERON:0002348 ! epicardium +intersection_of: RO:0000052 UBERON:0002348 ! inheres in epicardium +relationship: RO:0000052 UBERON:0002348 ! inheres in epicardium [Term] id: OBA:VT0003069 @@ -179106,7 +280258,7 @@ synonym: "morphology of anterior semicircular canal" EXACT [AUTO:patterns/patter is_a: OBA:1000802 ! anterior semicircular canal quality is_a: OBA:VT0002428 ! semicircular canal morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001841 ! anterior semicircular canal +intersection_of: RO:0000052 UBERON:0001841 ! inheres in anterior semicircular canal [Term] id: OBA:VT0003072 @@ -179115,8 +280267,8 @@ def: "The morphology of a metatarsal bone." [AUTO:patterns/patterns/entity_attri synonym: "morphology of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010105 ! hindlimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001448 ! metatarsal bone -relationship: inheres_in UBERON:0001448 ! metatarsal bone +intersection_of: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone +relationship: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone [Term] id: OBA:VT0003073 @@ -179126,8 +280278,8 @@ synonym: "morphology of metacarpus region" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004453 ! metacarpus region -relationship: inheres_in UBERON:0004453 ! metacarpus region +intersection_of: RO:0000052 UBERON:0004453 ! inheres in metacarpus region +relationship: RO:0000052 UBERON:0004453 ! inheres in metacarpus region [Term] id: OBA:VT0003074 @@ -179137,8 +280289,8 @@ synonym: "has number of of metacarpus region" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0004453 ! metacarpus region -relationship: inheres_in UBERON:0004453 ! metacarpus region +intersection_of: RO:0000052 UBERON:0004453 ! inheres in metacarpus region +relationship: RO:0000052 UBERON:0004453 ! inheres in metacarpus region [Term] id: OBA:VT0003081 @@ -179148,8 +280300,8 @@ synonym: "morphology of soleus muscle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001389 ! soleus muscle -relationship: inheres_in UBERON:0001389 ! soleus muscle +intersection_of: RO:0000052 UBERON:0001389 ! inheres in soleus muscle +relationship: RO:0000052 UBERON:0001389 ! inheres in soleus muscle [Term] id: OBA:VT0003082 @@ -179159,8 +280311,8 @@ synonym: "morphology of gastrocnemius" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001388 ! gastrocnemius -relationship: inheres_in UBERON:0001388 ! gastrocnemius +intersection_of: RO:0000052 UBERON:0001388 ! inheres in gastrocnemius +relationship: RO:0000052 UBERON:0001388 ! inheres in gastrocnemius [Term] id: OBA:VT0003083 @@ -179170,8 +280322,8 @@ synonym: "morphology of tibialis anterior" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000458 ! hindlimb zeugopod muscle quality is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001385 ! tibialis anterior -relationship: inheres_in UBERON:0001385 ! tibialis anterior +intersection_of: RO:0000052 UBERON:0001385 ! inheres in tibialis anterior +relationship: RO:0000052 UBERON:0001385 ! inheres in tibialis anterior [Term] id: OBA:VT0003084 @@ -179180,8 +280332,8 @@ def: "The morphology of a cell of skeletal muscle." [AUTO:patterns/patterns/enti synonym: "morphology of cell of skeletal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle -relationship: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle +relationship: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:VT0003085 @@ -179190,8 +280342,8 @@ def: "The morphology of a egg cylinder." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of egg cylinder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004013 ! egg cylinder -relationship: inheres_in UBERON:0004013 ! egg cylinder +intersection_of: RO:0000052 UBERON:0004013 ! inheres in egg cylinder +relationship: RO:0000052 UBERON:0004013 ! inheres in egg cylinder [Term] id: OBA:VT0003088 @@ -179200,8 +280352,8 @@ def: "The quality of a prepulse inhibition." [AUTO:patterns/patterns/entity_attr synonym: "quality of prepulse inhibition" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060134 ! prepulse inhibition -relationship: inheres_in GO:0060134 ! prepulse inhibition +intersection_of: RO:0000052 GO:0060134 ! inheres in prepulse inhibition +relationship: RO:0000052 GO:0060134 ! inheres in prepulse inhibition [Term] id: OBA:VT0003092 @@ -179211,7 +280363,7 @@ synonym: "thickness of substantia propria of cornea" EXACT [AUTO:patterns/patter is_a: OBA:0003768 ! substantia propria of cornea size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:VT0003093 @@ -179220,8 +280372,8 @@ def: "The morphology of a anterior stroma of cornea." [AUTO:patterns/patterns/en synonym: "morphology of anterior stroma of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003952 ! anterior stroma of cornea -relationship: inheres_in UBERON:0003952 ! anterior stroma of cornea +intersection_of: RO:0000052 UBERON:0003952 ! inheres in anterior stroma of cornea +relationship: RO:0000052 UBERON:0003952 ! inheres in anterior stroma of cornea [Term] id: OBA:VT0003094 @@ -179230,8 +280382,8 @@ def: "The morphology of a posterior stroma of cornea." [AUTO:patterns/patterns/e synonym: "morphology of posterior stroma of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003953 ! posterior stroma of cornea -relationship: inheres_in UBERON:0003953 ! posterior stroma of cornea +intersection_of: RO:0000052 UBERON:0003953 ! inheres in posterior stroma of cornea +relationship: RO:0000052 UBERON:0003953 ! inheres in posterior stroma of cornea [Term] id: OBA:VT0003102 @@ -179241,7 +280393,7 @@ synonym: "thickness of sclera" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002120 ! sclera size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001773 ! sclera +intersection_of: RO:0000052 UBERON:0001773 ! inheres in sclera [Term] id: OBA:VT0003104 @@ -179251,7 +280403,7 @@ synonym: "size of skull" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000438 ! skull morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003129 ! skull +intersection_of: RO:0000052 UBERON:0003129 ! inheres in skull [Term] id: OBA:VT0003105 @@ -179261,8 +280413,8 @@ synonym: "morphology of cardiac atrium" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002081 ! cardiac atrium -relationship: inheres_in UBERON:0002081 ! cardiac atrium +intersection_of: RO:0000052 UBERON:0002081 ! inheres in cardiac atrium +relationship: RO:0000052 UBERON:0002081 ! inheres in cardiac atrium [Term] id: OBA:VT0003110 @@ -179272,8 +280424,8 @@ synonym: "morphology of lateral process of malleus" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014397 ! lateral process of malleus -relationship: inheres_in UBERON:0014397 ! lateral process of malleus +intersection_of: RO:0000052 UBERON:0014397 ! inheres in lateral process of malleus +relationship: RO:0000052 UBERON:0014397 ! inheres in lateral process of malleus [Term] id: OBA:VT0003112 @@ -179283,7 +280435,7 @@ synonym: "size of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000678 ! parathyroid gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:VT0003115 @@ -179292,8 +280444,8 @@ def: "The quality of a respiratory system development." [AUTO:patterns/patterns/ synonym: "quality of respiratory system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060541 ! respiratory system development -relationship: inheres_in GO:0060541 ! respiratory system development +intersection_of: RO:0000052 GO:0060541 ! inheres in respiratory system development +relationship: RO:0000052 GO:0060541 ! inheres in respiratory system development [Term] id: OBA:VT0003120 @@ -179302,8 +280454,8 @@ def: "The morphology of a trachea cartilage." [AUTO:patterns/patterns/entity_att synonym: "morphology of trachea cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003604 ! trachea cartilage -relationship: inheres_in UBERON:0003604 ! trachea cartilage +intersection_of: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage +relationship: RO:0000052 UBERON:0003604 ! inheres in trachea cartilage [Term] id: OBA:VT0003126 @@ -179313,8 +280465,8 @@ synonym: "morphology of mammalian vulva" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000997 ! mammalian vulva -relationship: inheres_in UBERON:0000997 ! mammalian vulva +intersection_of: RO:0000052 UBERON:0000997 ! inheres in mammalian vulva +relationship: RO:0000052 UBERON:0000997 ! inheres in mammalian vulva [Term] id: OBA:VT0003127 @@ -179324,7 +280476,7 @@ synonym: "morphology of clitoris" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000310 ! clitoris quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002411 ! clitoris +intersection_of: RO:0000052 UBERON:0002411 ! inheres in clitoris [Term] id: OBA:VT0003135 @@ -179333,8 +280485,8 @@ def: "The has number of of a reticulocyte." [AUTO:patterns/patterns/entity_attri synonym: "has number of of reticulocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000237 ! blood cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000558 ! reticulocyte -relationship: inheres_in CL:0000558 ! reticulocyte +intersection_of: RO:0000052 CL:0000558 ! inheres in reticulocyte +relationship: RO:0000052 CL:0000558 ! inheres in reticulocyte [Term] id: OBA:VT0003140 @@ -179344,7 +280496,7 @@ synonym: "size of cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003105 ! heart atrium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002081 ! cardiac atrium +intersection_of: RO:0000052 UBERON:0002081 ! inheres in cardiac atrium [Term] id: OBA:VT0003143 @@ -179354,7 +280506,7 @@ synonym: "size of otolith" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002894 ! otolith morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002280 ! otolith +intersection_of: RO:0000052 UBERON:0002280 ! inheres in otolith [Term] id: OBA:VT0003144 @@ -179364,8 +280516,8 @@ synonym: "has number of of otolith" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002280 ! otolith -relationship: inheres_in UBERON:0002280 ! otolith +intersection_of: RO:0000052 UBERON:0002280 ! inheres in otolith +relationship: RO:0000052 UBERON:0002280 ! inheres in otolith [Term] id: OBA:VT0003149 @@ -179375,8 +280527,8 @@ synonym: "morphology of tectorial membrane of cochlea" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002233 ! tectorial membrane of cochlea -relationship: inheres_in UBERON:0002233 ! tectorial membrane of cochlea +intersection_of: RO:0000052 UBERON:0002233 ! inheres in tectorial membrane of cochlea +relationship: RO:0000052 UBERON:0002233 ! inheres in tectorial membrane of cochlea [Term] id: OBA:VT0003151 @@ -179386,8 +280538,8 @@ synonym: "morphology of tunnel of Corti" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005972 ! tunnel of Corti -relationship: inheres_in UBERON:0005972 ! tunnel of Corti +intersection_of: RO:0000052 UBERON:0005972 ! inheres in tunnel of Corti +relationship: RO:0000052 UBERON:0005972 ! inheres in tunnel of Corti [Term] id: OBA:VT0003154 @@ -179397,7 +280549,7 @@ synonym: "morphology of soft palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000337 ! soft palate quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001733 ! soft palate +intersection_of: RO:0000052 UBERON:0001733 ! inheres in soft palate [Term] id: OBA:VT0003156 @@ -179406,8 +280558,8 @@ def: "The quality of a leukocyte migration." [AUTO:patterns/patterns/entity_attr synonym: "quality of leukocyte migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050900 ! leukocyte migration -relationship: inheres_in GO:0050900 ! leukocyte migration +intersection_of: RO:0000052 GO:0050900 ! inheres in leukocyte migration +relationship: RO:0000052 GO:0050900 ! inheres in leukocyte migration [Term] id: OBA:VT0003159 @@ -179416,8 +280568,8 @@ def: "The morphology of a smooth muscle of esophagus." [AUTO:patterns/patterns/e synonym: "morphology of smooth muscle of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002112 ! smooth muscle of esophagus -relationship: inheres_in UBERON:0002112 ! smooth muscle of esophagus +intersection_of: RO:0000052 UBERON:0002112 ! inheres in smooth muscle of esophagus +relationship: RO:0000052 UBERON:0002112 ! inheres in smooth muscle of esophagus [Term] id: OBA:VT0003162 @@ -179427,7 +280579,7 @@ synonym: "size of lateral semicircular canal" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003245 ! semicircular canal size is_a: OBA:VT0000037 ! lateral semicircular canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001843 ! lateral semicircular canal +intersection_of: RO:0000052 UBERON:0001843 ! inheres in lateral semicircular canal [Term] id: OBA:VT0003164 @@ -179437,7 +280589,7 @@ synonym: "size of posterior semicircular canal" EXACT [AUTO:patterns/patterns/en is_a: OBA:0003245 ! semicircular canal size is_a: OBA:VT0002858 ! posterior semicircular canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001842 ! posterior semicircular canal +intersection_of: RO:0000052 UBERON:0001842 ! inheres in posterior semicircular canal [Term] id: OBA:VT0003166 @@ -179447,7 +280599,7 @@ synonym: "size of anterior semicircular canal" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0003245 ! semicircular canal size is_a: OBA:VT0003069 ! superior semicircular canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001841 ! anterior semicircular canal +intersection_of: RO:0000052 UBERON:0001841 ! inheres in anterior semicircular canal [Term] id: OBA:VT0003167 @@ -179457,8 +280609,8 @@ synonym: "morphology of scala tympani" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001864 ! scala tympani -relationship: inheres_in UBERON:0001864 ! scala tympani +intersection_of: RO:0000052 UBERON:0001864 ! inheres in scala tympani +relationship: RO:0000052 UBERON:0001864 ! inheres in scala tympani [Term] id: OBA:VT0003168 @@ -179468,8 +280620,8 @@ synonym: "morphology of perilymphatic space" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002278 ! perilymphatic space -relationship: inheres_in UBERON:0002278 ! perilymphatic space +intersection_of: RO:0000052 UBERON:0002278 ! inheres in perilymphatic space +relationship: RO:0000052 UBERON:0002278 ! inheres in perilymphatic space [Term] id: OBA:VT0003169 @@ -179479,8 +280631,8 @@ synonym: "morphology of scala media" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002295 ! scala media -relationship: inheres_in UBERON:0002295 ! scala media +intersection_of: RO:0000052 UBERON:0002295 ! inheres in scala media +relationship: RO:0000052 UBERON:0002295 ! inheres in scala media [Term] id: OBA:VT0003179 @@ -179490,8 +280642,8 @@ synonym: "amount of platelet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000866 ! blood cell quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000233 ! platelet -relationship: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet +relationship: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:VT0003208 @@ -179501,8 +280653,8 @@ synonym: "morphology of neuromere" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004731 ! neuromere -relationship: inheres_in UBERON:0004731 ! neuromere +intersection_of: RO:0000052 UBERON:0004731 ! inheres in neuromere +relationship: RO:0000052 UBERON:0004731 ! inheres in neuromere [Term] id: OBA:VT0003209 @@ -179511,8 +280663,8 @@ def: "The morphology of a lung elastic tissue." [AUTO:patterns/patterns/entity_a synonym: "morphology of lung elastic tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002276 ! lung interstitium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003615 ! lung elastic tissue -relationship: inheres_in UBERON:0003615 ! lung elastic tissue +intersection_of: RO:0000052 UBERON:0003615 ! inheres in lung elastic tissue +relationship: RO:0000052 UBERON:0003615 ! inheres in lung elastic tissue [Term] id: OBA:VT0003211 @@ -179521,8 +280673,8 @@ def: "The morphology of a aorta elastic tissue." [AUTO:patterns/patterns/entity_ synonym: "morphology of aorta elastic tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006083 ! blood vessel elastic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003609 ! aorta elastic tissue -relationship: inheres_in UBERON:0003609 ! aorta elastic tissue +intersection_of: RO:0000052 UBERON:0003609 ! inheres in aorta elastic tissue +relationship: RO:0000052 UBERON:0003609 ! inheres in aorta elastic tissue [Term] id: OBA:VT0003228 @@ -179532,8 +280684,8 @@ synonym: "morphology of sinus venosus" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002063 ! sinus venosus -relationship: inheres_in UBERON:0002063 ! sinus venosus +intersection_of: RO:0000052 UBERON:0002063 ! inheres in sinus venosus +relationship: RO:0000052 UBERON:0002063 ! inheres in sinus venosus [Term] id: OBA:VT0003231 @@ -179543,8 +280695,8 @@ synonym: "morphology of placental labyrinth vasculature" EXACT [AUTO:patterns/pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003970 ! placental labyrinth vasculature -relationship: inheres_in UBERON:0003970 ! placental labyrinth vasculature +intersection_of: RO:0000052 UBERON:0003970 ! inheres in placental labyrinth vasculature +relationship: RO:0000052 UBERON:0003970 ! inheres in placental labyrinth vasculature [Term] id: OBA:VT0003232 @@ -179553,8 +280705,8 @@ def: "The quality of a forebrain development." [AUTO:patterns/patterns/entity_at synonym: "quality of forebrain development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030900 ! forebrain development -relationship: inheres_in GO:0030900 ! forebrain development +intersection_of: RO:0000052 GO:0030900 ! inheres in forebrain development +relationship: RO:0000052 GO:0030900 ! inheres in forebrain development [Term] id: OBA:VT0003235 @@ -179564,8 +280716,8 @@ synonym: "morphology of alisphenoid bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006721 ! alisphenoid bone -relationship: inheres_in UBERON:0006721 ! alisphenoid bone +intersection_of: RO:0000052 UBERON:0006721 ! inheres in alisphenoid bone +relationship: RO:0000052 UBERON:0006721 ! inheres in alisphenoid bone [Term] id: OBA:VT0003236 @@ -179575,8 +280727,8 @@ synonym: "morphology of capsule of lens" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001804 ! capsule of lens -relationship: inheres_in UBERON:0001804 ! capsule of lens +intersection_of: RO:0000052 UBERON:0001804 ! inheres in capsule of lens +relationship: RO:0000052 UBERON:0001804 ! inheres in capsule of lens [Term] id: OBA:VT0003237 @@ -179586,8 +280738,8 @@ synonym: "morphology of epithelium of lens" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001803 ! epithelium of lens -relationship: inheres_in UBERON:0001803 ! epithelium of lens +intersection_of: RO:0000052 UBERON:0001803 ! inheres in epithelium of lens +relationship: RO:0000052 UBERON:0001803 ! inheres in epithelium of lens [Term] id: OBA:VT0003240 @@ -179596,8 +280748,8 @@ def: "The amount of a hippocampal neuron." [AUTO:patterns/patterns/entity_attrib synonym: "amount of hippocampal neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002608 ! hippocampal neuron -relationship: inheres_in CL:0002608 ! hippocampal neuron +intersection_of: RO:0000052 CL:0002608 ! inheres in hippocampal neuron +relationship: RO:0000052 CL:0002608 ! inheres in hippocampal neuron [Term] id: OBA:VT0003243 @@ -179606,8 +280758,8 @@ def: "The morphology of a dopaminergic neuron." [AUTO:patterns/patterns/entity_a synonym: "morphology of dopaminergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000700 ! dopaminergic neuron -relationship: inheres_in CL:0000700 ! dopaminergic neuron +intersection_of: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron +relationship: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron [Term] id: OBA:VT0003244 @@ -179617,8 +280769,8 @@ synonym: "has number of of dopaminergic neuron" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000700 ! dopaminergic neuron -relationship: inheres_in CL:0000700 ! dopaminergic neuron +intersection_of: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron +relationship: RO:0000052 CL:0000700 ! inheres in dopaminergic neuron [Term] id: OBA:VT0003252 @@ -179628,8 +280780,8 @@ synonym: "functionality of bile duct" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002394 ! bile duct -relationship: inheres_in UBERON:0002394 ! bile duct +intersection_of: RO:0000052 UBERON:0002394 ! inheres in bile duct +relationship: RO:0000052 UBERON:0002394 ! inheres in bile duct [Term] id: OBA:VT0003253 @@ -179639,7 +280791,7 @@ synonym: "size of bile duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0002928 ! bile duct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002394 ! bile duct +intersection_of: RO:0000052 UBERON:0002394 ! inheres in bile duct [Term] id: OBA:VT0003257 @@ -179649,7 +280801,7 @@ synonym: "morphology of abdominal wall" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000561 ! abdominal wall quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003697 ! abdominal wall +intersection_of: RO:0000052 UBERON:0003697 ! inheres in abdominal wall [Term] id: OBA:VT0003271 @@ -179659,8 +280811,8 @@ synonym: "morphology of duodenum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002114 ! duodenum -relationship: inheres_in UBERON:0002114 ! duodenum +intersection_of: RO:0000052 UBERON:0002114 ! inheres in duodenum +relationship: RO:0000052 UBERON:0002114 ! inheres in duodenum [Term] id: OBA:VT0003283 @@ -179670,7 +280822,7 @@ synonym: "orientation of digestive system element" EXACT [AUTO:patterns/patterns is_a: OBA:0003802 ! digestive system element position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0013765 ! digestive system element +intersection_of: RO:0000052 UBERON:0013765 ! inheres in digestive system element [Term] id: OBA:VT0003284 @@ -179679,8 +280831,8 @@ def: "The position of a large intestine." [AUTO:patterns/patterns/entity_attribu synonym: "position of large intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003802 ! digestive system element position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000059 ! large intestine -relationship: inheres_in UBERON:0000059 ! large intestine +intersection_of: RO:0000052 UBERON:0000059 ! inheres in large intestine +relationship: RO:0000052 UBERON:0000059 ! inheres in large intestine [Term] id: OBA:VT0003308 @@ -179689,8 +280841,8 @@ def: "The morphology of a obsolete sensory epithelium of spiral organ." [AUTO:pa synonym: "morphology of obsolete sensory epithelium of spiral organ" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013763 ! obsolete sensory epithelium of spiral organ -relationship: inheres_in UBERON:0013763 ! obsolete sensory epithelium of spiral organ +intersection_of: RO:0000052 UBERON:0013763 ! inheres in obsolete sensory epithelium of spiral organ +relationship: RO:0000052 UBERON:0013763 ! inheres in obsolete sensory epithelium of spiral organ [Term] id: OBA:VT0003309 @@ -179700,8 +280852,8 @@ synonym: "morphology of cochlear modiolus" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006723 ! cochlear modiolus -relationship: inheres_in UBERON:0006723 ! cochlear modiolus +intersection_of: RO:0000052 UBERON:0006723 ! inheres in cochlear modiolus +relationship: RO:0000052 UBERON:0006723 ! inheres in cochlear modiolus [Term] id: OBA:VT0003310 @@ -179711,7 +280863,7 @@ synonym: "size of cochlear modiolus" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003309 ! modiolus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006723 ! cochlear modiolus +intersection_of: RO:0000052 UBERON:0006723 ! inheres in cochlear modiolus [Term] id: OBA:VT0003311 @@ -179728,8 +280880,8 @@ synonym: "morphology of perineum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002356 ! perineum -relationship: inheres_in UBERON:0002356 ! perineum +intersection_of: RO:0000052 UBERON:0002356 ! inheres in perineum +relationship: RO:0000052 UBERON:0002356 ! inheres in perineum [Term] id: OBA:VT0003330 @@ -179739,7 +280891,7 @@ synonym: "morphology of pharyngotympanic tube" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000740 ! pharyngotympanic tube quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002393 ! pharyngotympanic tube +intersection_of: RO:0000052 UBERON:0002393 ! inheres in pharyngotympanic tube [Term] id: OBA:VT0003339 @@ -179749,8 +280901,8 @@ synonym: "has number of of type B pancreatic cell" EXACT [AUTO:patterns/patterns is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000169 ! type B pancreatic cell -relationship: inheres_in CL:0000169 ! type B pancreatic cell +intersection_of: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell +relationship: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell [Term] id: OBA:VT0003345 @@ -179760,7 +280912,7 @@ synonym: "has number of of rib" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000534 ! rib quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002228 ! rib +intersection_of: RO:0000052 UBERON:0002228 ! inheres in rib [Term] id: OBA:VT0003346 @@ -179769,8 +280921,8 @@ def: "The morphology of a pectoral muscle." [AUTO:patterns/patterns/entity_attri synonym: "morphology of pectoral muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001495 ! pectoral muscle -relationship: inheres_in UBERON:0001495 ! pectoral muscle +intersection_of: RO:0000052 UBERON:0001495 ! inheres in pectoral muscle +relationship: RO:0000052 UBERON:0001495 ! inheres in pectoral muscle [Term] id: OBA:VT0003349 @@ -179794,8 +280946,8 @@ def: "The quality of a luteinization." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of luteinization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001553 ! luteinization -relationship: inheres_in GO:0001553 ! luteinization +intersection_of: RO:0000052 GO:0001553 ! inheres in luteinization +relationship: RO:0000052 GO:0001553 ! inheres in luteinization [Term] id: OBA:VT0003357 @@ -179804,8 +280956,8 @@ def: "The quality of a granulosa cell differentiation." [AUTO:patterns/patterns/ synonym: "quality of granulosa cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060014 ! granulosa cell differentiation -relationship: inheres_in GO:0060014 ! granulosa cell differentiation +intersection_of: RO:0000052 GO:0060014 ! inheres in granulosa cell differentiation +relationship: RO:0000052 GO:0060014 ! inheres in granulosa cell differentiation [Term] id: OBA:VT0003358 @@ -179814,8 +280966,8 @@ def: "The morphology of a hypaxial myotome region." [AUTO:patterns/patterns/enti synonym: "morphology of hypaxial myotome region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000759 ! skeletal muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003895 ! hypaxial myotome region -relationship: inheres_in UBERON:0003895 ! hypaxial myotome region +intersection_of: RO:0000052 UBERON:0003895 ! inheres in hypaxial myotome region +relationship: RO:0000052 UBERON:0003895 ! inheres in hypaxial myotome region [Term] id: OBA:VT0003366 @@ -179839,8 +280991,8 @@ def: "The quality of a gluconeogenesis." [AUTO:patterns/patterns/entity_attribut synonym: "quality of gluconeogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015088 ! glucose metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006094 ! gluconeogenesis -relationship: inheres_in GO:0006094 ! gluconeogenesis +intersection_of: RO:0000052 GO:0006094 ! inheres in gluconeogenesis +relationship: RO:0000052 GO:0006094 ! inheres in gluconeogenesis [Term] id: OBA:VT0003384 @@ -179849,8 +281001,8 @@ def: "The morphology of a ventral body wall." [AUTO:patterns/patterns/entity_att synonym: "morphology of ventral body wall" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003385 ! body wall morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0017648 ! ventral body wall -relationship: inheres_in UBERON:0017648 ! ventral body wall +intersection_of: RO:0000052 UBERON:0017648 ! inheres in ventral body wall +relationship: RO:0000052 UBERON:0017648 ! inheres in ventral body wall [Term] id: OBA:VT0003385 @@ -179860,8 +281012,8 @@ synonym: "morphology of body wall" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000309 ! body wall -relationship: inheres_in UBERON:0000309 ! body wall +intersection_of: RO:0000052 UBERON:0000309 ! inheres in body wall +relationship: RO:0000052 UBERON:0000309 ! inheres in body wall [Term] id: OBA:VT0003396 @@ -179870,8 +281022,8 @@ def: "The quality of a embryonic hemopoiesis." [AUTO:patterns/patterns/entity_at synonym: "quality of embryonic hemopoiesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002123 ! hematopoiesis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0035162 ! embryonic hemopoiesis -relationship: inheres_in GO:0035162 ! embryonic hemopoiesis +intersection_of: RO:0000052 GO:0035162 ! inheres in embryonic hemopoiesis +relationship: RO:0000052 GO:0035162 ! inheres in embryonic hemopoiesis [Term] id: OBA:VT0003398 @@ -179881,7 +281033,7 @@ synonym: "size of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000759 ! skeletal muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:VT0003399 @@ -179891,7 +281043,7 @@ synonym: "size of cell of skeletal muscle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000055 ! cell size is_a: OBA:VT0003084 ! skeletal muscle fiber morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:VT0003401 @@ -179901,7 +281053,7 @@ synonym: "size of post-anal tail bud" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0002861 ! tail bud morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002533 ! post-anal tail bud +intersection_of: RO:0000052 UBERON:0002533 ! inheres in post-anal tail bud [Term] id: OBA:VT0003402 @@ -179911,7 +281063,7 @@ synonym: "mass of liver" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000635 ! liver quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002107 ! liver +intersection_of: RO:0000052 UBERON:0002107 ! inheres in liver [Term] id: OBA:VT0003405 @@ -179921,7 +281073,7 @@ synonym: "shape of platelet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000052 ! cell shape is_a: OBA:0003276 ! platelet morphology intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:VT0003409 @@ -179932,7 +281084,7 @@ is_a: OBA:0003727 ! cartilage tissue size is_a: OBA:VT0000165 ! hypertrophic chondrocyte zone morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0006772 ! long bone epiphyseal plate hypertrophic zone +intersection_of: RO:0000052 UBERON:0006772 ! inheres in long bone epiphyseal plate hypertrophic zone [Term] id: OBA:VT0003421 @@ -179941,8 +281093,8 @@ def: "The quality of a thyroid gland development." [AUTO:patterns/patterns/entit synonym: "quality of thyroid gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030878 ! thyroid gland development -relationship: inheres_in GO:0030878 ! thyroid gland development +intersection_of: RO:0000052 GO:0030878 ! inheres in thyroid gland development +relationship: RO:0000052 GO:0030878 ! inheres in thyroid gland development [Term] id: OBA:VT0003431 @@ -179951,8 +281103,8 @@ def: "The functionality of a parathyroid gland." [AUTO:patterns/patterns/entity_ synonym: "functionality of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005865 ! endocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001132 ! parathyroid gland -relationship: inheres_in UBERON:0001132 ! parathyroid gland +intersection_of: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland +relationship: RO:0000052 UBERON:0001132 ! inheres in parathyroid gland [Term] id: OBA:VT0003437 @@ -179962,8 +281114,8 @@ synonym: "morphology of carotid body" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001629 ! carotid body -relationship: inheres_in UBERON:0001629 ! carotid body +intersection_of: RO:0000052 UBERON:0001629 ! inheres in carotid body +relationship: RO:0000052 UBERON:0001629 ! inheres in carotid body [Term] id: OBA:VT0003442 @@ -179979,8 +281131,8 @@ def: "The quality of a neurotransmitter uptake." [AUTO:patterns/patterns/entity_ synonym: "quality of neurotransmitter uptake" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001504 ! neurotransmitter uptake -relationship: inheres_in GO:0001504 ! neurotransmitter uptake +intersection_of: RO:0000052 GO:0001504 ! inheres in neurotransmitter uptake +relationship: RO:0000052 GO:0001504 ! inheres in neurotransmitter uptake [Term] id: OBA:VT0003446 @@ -179990,8 +281142,8 @@ synonym: "amount of kidney cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1000497 ! kidney cell -relationship: inheres_in CL:1000497 ! kidney cell +intersection_of: RO:0000052 CL:1000497 ! inheres in kidney cell +relationship: RO:0000052 CL:1000497 ! inheres in kidney cell [Term] id: OBA:VT0003450 @@ -180001,7 +281153,7 @@ synonym: "size of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001944 ! pancreas morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:VT0003452 @@ -180011,8 +281163,8 @@ synonym: "morphology of parotid gland" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0004285 ! serous gland morphology is_a: OBA:VT0003792 ! major salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001831 ! parotid gland -relationship: inheres_in UBERON:0001831 ! parotid gland +intersection_of: RO:0000052 UBERON:0001831 ! inheres in parotid gland +relationship: RO:0000052 UBERON:0001831 ! inheres in parotid gland [Term] id: OBA:VT0003456 @@ -180022,7 +281174,7 @@ synonym: "size of tail" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002111 ! tail morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002415 ! tail +intersection_of: RO:0000052 UBERON:0002415 ! inheres in tail [Term] id: OBA:VT0003501 @@ -180031,8 +281183,8 @@ def: "The quality of a iodide oxidation." [AUTO:patterns/patterns/entity_attribu synonym: "quality of iodide oxidation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070277 ! iodide oxidation -relationship: inheres_in GO:0070277 ! iodide oxidation +intersection_of: RO:0000052 GO:0070277 ! inheres in iodide oxidation +relationship: RO:0000052 GO:0070277 ! inheres in iodide oxidation [Term] id: OBA:VT0003506 @@ -180041,8 +281193,8 @@ def: "The quality of a growth hormone secretion." [AUTO:patterns/patterns/entity synonym: "quality of growth hormone secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030252 ! growth hormone secretion -relationship: inheres_in GO:0030252 ! growth hormone secretion +intersection_of: RO:0000052 GO:0030252 ! inheres in growth hormone secretion +relationship: RO:0000052 GO:0030252 ! inheres in growth hormone secretion [Term] id: OBA:VT0003507 @@ -180052,7 +281204,7 @@ synonym: "functionality of ovary" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000545 ! ovary quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:VT0003508 @@ -180070,7 +281222,7 @@ synonym: "morphology of genital labium" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000187 ! genital labium quality is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004084 ! genital labium +intersection_of: RO:0000052 UBERON:0004084 ! inheres in genital labium [Term] id: OBA:VT0003512 @@ -180080,7 +281232,7 @@ synonym: "size of genital labium" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003618 ! zone of skin size is_a: OBA:VT0003511 ! labium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004084 ! genital labium +intersection_of: RO:0000052 UBERON:0004084 ! inheres in genital labium [Term] id: OBA:VT0003515 @@ -180090,7 +281242,7 @@ synonym: "morphology of labium majora" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000533 ! labium majora quality is_a: OBA:VT0003511 ! labium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:VT0003517 @@ -180100,7 +281252,7 @@ synonym: "size of labium majora" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003512 ! labia size trait is_a: OBA:VT0003515 ! labia majora morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:VT0003519 @@ -180110,7 +281262,7 @@ synonym: "shape of labium majora" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0003515 ! labia majora morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004085 ! labium majora +intersection_of: RO:0000052 UBERON:0004085 ! inheres in labium majora [Term] id: OBA:VT0003520 @@ -180120,7 +281272,7 @@ synonym: "morphology of labium minora" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000344 ! labium minora quality is_a: OBA:VT0003511 ! labium morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:VT0003522 @@ -180130,7 +281282,7 @@ synonym: "size of labium minora" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003512 ! labia size trait is_a: OBA:VT0003520 ! labia minora morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:VT0003524 @@ -180140,7 +281292,7 @@ synonym: "shape of labium minora" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0003520 ! labia minora morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0004014 ! labium minora +intersection_of: RO:0000052 UBERON:0004014 ! inheres in labium minora [Term] id: OBA:VT0003528 @@ -180150,7 +281302,7 @@ synonym: "size of mammalian vulva" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003126 ! vulva morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000997 ! mammalian vulva +intersection_of: RO:0000052 UBERON:0000997 ! inheres in mammalian vulva [Term] id: OBA:VT0003529 @@ -180160,7 +281312,7 @@ synonym: "size of clitoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003127 ! clitoris morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002411 ! clitoris +intersection_of: RO:0000052 UBERON:0002411 ! inheres in clitoris [Term] id: OBA:VT0003531 @@ -180169,8 +281321,8 @@ def: "The quality of a vagina development." [AUTO:patterns/patterns/entity_attri synonym: "quality of vagina development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060068 ! vagina development -relationship: inheres_in GO:0060068 ! vagina development +intersection_of: RO:0000052 GO:0060068 ! inheres in vagina development +relationship: RO:0000052 GO:0060068 ! inheres in vagina development [Term] id: OBA:VT0003553 @@ -180180,7 +281332,7 @@ synonym: "morphology of prepuce of penis" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000339 ! prepuce of penis quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001332 ! prepuce of penis +intersection_of: RO:0000052 UBERON:0001332 ! inheres in prepuce of penis [Term] id: OBA:VT0003562 @@ -180189,8 +281341,8 @@ def: "The functionality of a type B pancreatic cell." [AUTO:patterns/patterns/en synonym: "functionality of type B pancreatic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000169 ! type B pancreatic cell -relationship: inheres_in CL:0000169 ! type B pancreatic cell +intersection_of: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell +relationship: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell [Term] id: OBA:VT0003563 @@ -180199,8 +281351,8 @@ def: "The functionality of a pancreatic A cell." [AUTO:patterns/patterns/entity_ synonym: "functionality of pancreatic A cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000171 ! pancreatic A cell -relationship: inheres_in CL:0000171 ! pancreatic A cell +intersection_of: RO:0000052 CL:0000171 ! inheres in pancreatic A cell +relationship: RO:0000052 CL:0000171 ! inheres in pancreatic A cell [Term] id: OBA:VT0003564 @@ -180209,8 +281361,8 @@ def: "The quality of a insulin secretion." [AUTO:patterns/patterns/entity_attrib synonym: "quality of insulin secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030073 ! insulin secretion -relationship: inheres_in GO:0030073 ! insulin secretion +intersection_of: RO:0000052 GO:0030073 ! inheres in insulin secretion +relationship: RO:0000052 GO:0030073 ! inheres in insulin secretion [Term] id: OBA:VT0003565 @@ -180219,8 +281371,8 @@ def: "The quality of a glucagon secretion." [AUTO:patterns/patterns/entity_attri synonym: "quality of glucagon secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070091 ! glucagon secretion -relationship: inheres_in GO:0070091 ! glucagon secretion +intersection_of: RO:0000052 GO:0070091 ! inheres in glucagon secretion +relationship: RO:0000052 GO:0070091 ! inheres in glucagon secretion [Term] id: OBA:VT0003568 @@ -180230,8 +281382,8 @@ synonym: "morphology of uterine lumen" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013769 ! uterine lumen -relationship: inheres_in UBERON:0013769 ! uterine lumen +intersection_of: RO:0000052 UBERON:0013769 ! inheres in uterine lumen +relationship: RO:0000052 UBERON:0013769 ! inheres in uterine lumen [Term] id: OBA:VT0003572 @@ -180240,8 +281392,8 @@ def: "The quality of a uterus development." [AUTO:patterns/patterns/entity_attri synonym: "quality of uterus development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060065 ! uterus development -relationship: inheres_in GO:0060065 ! uterus development +intersection_of: RO:0000052 GO:0060065 ! inheres in uterus development +relationship: RO:0000052 GO:0060065 ! inheres in uterus development [Term] id: OBA:VT0003574 @@ -180251,7 +281403,7 @@ synonym: "morphology of fallopian tube" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000290 ! fallopian tube quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003889 ! fallopian tube +intersection_of: RO:0000052 UBERON:0003889 ! inheres in fallopian tube [Term] id: OBA:VT0003576 @@ -180261,7 +281413,7 @@ synonym: "size of fallopian tube" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003574 ! oviduct morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003889 ! fallopian tube +intersection_of: RO:0000052 UBERON:0003889 ! inheres in fallopian tube [Term] id: OBA:VT0003585 @@ -180271,7 +281423,7 @@ synonym: "size of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0000534 ! ureter morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0003588 @@ -180281,7 +281433,7 @@ synonym: "width of ureter" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003585 ! ureter size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0003589 @@ -180291,8 +281443,8 @@ synonym: "functionality of ureter" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000056 ! ureter -relationship: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter +relationship: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0003592 @@ -180302,7 +281454,7 @@ synonym: "width of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003594 ! urethra size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:VT0003594 @@ -180312,7 +281464,7 @@ synonym: "size of urethra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000537 ! urethra morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000057 ! urethra +intersection_of: RO:0000052 UBERON:0000057 ! inheres in urethra [Term] id: OBA:VT0003599 @@ -180322,7 +281474,7 @@ synonym: "size of penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005187 ! penis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000989 ! penis +intersection_of: RO:0000052 UBERON:0000989 ! inheres in penis [Term] id: OBA:VT0003606 @@ -180332,8 +281484,8 @@ synonym: "functionality of nephron" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001285 ! nephron -relationship: inheres_in UBERON:0001285 ! nephron +intersection_of: RO:0000052 UBERON:0001285 ! inheres in nephron +relationship: RO:0000052 UBERON:0001285 ! inheres in nephron [Term] id: OBA:VT0003607 @@ -180342,8 +281494,8 @@ def: "The functionality of a prostate gland." [AUTO:patterns/patterns/entity_att synonym: "functionality of prostate gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005811 ! male reproductive gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002367 ! prostate gland -relationship: inheres_in UBERON:0002367 ! prostate gland +intersection_of: RO:0000052 UBERON:0002367 ! inheres in prostate gland +relationship: RO:0000052 UBERON:0002367 ! inheres in prostate gland [Term] id: OBA:VT0003618 @@ -180352,8 +281504,8 @@ def: "The size of a cervical os." [AUTO:patterns/patterns/entity_attribute] synonym: "size of cervical os" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013758 ! cervical os -relationship: inheres_in UBERON:0013758 ! cervical os +intersection_of: RO:0000052 UBERON:0013758 ! inheres in cervical os +relationship: RO:0000052 UBERON:0013758 ! inheres in cervical os [Term] id: OBA:VT0003619 @@ -180363,7 +281515,7 @@ synonym: "color of urine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000056 ! urine trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001088 ! urine +intersection_of: RO:0000052 UBERON:0001088 ! inheres in urine [Term] id: OBA:VT0003626 @@ -180372,8 +281524,8 @@ def: "The amount of a kidney medulla cell." [AUTO:patterns/patterns/entity_attri synonym: "amount of kidney medulla cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003446 ! kidney cell quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:1000504 ! kidney medulla cell -relationship: inheres_in CL:1000504 ! kidney medulla cell +intersection_of: RO:0000052 CL:1000504 ! inheres in kidney medulla cell +relationship: RO:0000052 CL:1000504 ! inheres in kidney medulla cell [Term] id: OBA:VT0003627 @@ -180382,8 +281534,8 @@ def: "The quality of a leukocyte tethering or rolling." [AUTO:patterns/patterns/ synonym: "quality of leukocyte tethering or rolling" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003628 ! leukocyte adhesion trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050901 ! leukocyte tethering or rolling -relationship: inheres_in GO:0050901 ! leukocyte tethering or rolling +intersection_of: RO:0000052 GO:0050901 ! inheres in leukocyte tethering or rolling +relationship: RO:0000052 GO:0050901 ! inheres in leukocyte tethering or rolling [Term] id: OBA:VT0003628 @@ -180392,8 +281544,8 @@ def: "The quality of a leukocyte cell-cell adhesion." [AUTO:patterns/patterns/en synonym: "quality of leukocyte cell-cell adhesion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007159 ! leukocyte cell-cell adhesion -relationship: inheres_in GO:0007159 ! leukocyte cell-cell adhesion +intersection_of: RO:0000052 GO:0007159 ! inheres in leukocyte cell-cell adhesion +relationship: RO:0000052 GO:0007159 ! inheres in leukocyte cell-cell adhesion [Term] id: OBA:VT0003630 @@ -180403,7 +281555,7 @@ synonym: "morphology of urothelium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000889 ! urothelium quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000365 ! urothelium +intersection_of: RO:0000052 UBERON:0000365 ! inheres in urothelium [Term] id: OBA:VT0003632 @@ -180413,7 +281565,7 @@ synonym: "morphology of nervous system" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT1000781 ! nervous/sensory system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001016 ! nervous system +intersection_of: RO:0000052 UBERON:0001016 ! inheres in nervous system [Term] id: OBA:VT0003633 @@ -180423,7 +281575,7 @@ synonym: "functionality of nervous system" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT1000781 ! nervous/sensory system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001016 ! nervous system +intersection_of: RO:0000052 UBERON:0001016 ! inheres in nervous system [Term] id: OBA:VT0003634 @@ -180433,7 +281585,7 @@ synonym: "morphology of glial cell" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000236 ! glial cell quality is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000125 ! glial cell +intersection_of: RO:0000052 CL:0000125 ! inheres in glial cell [Term] id: OBA:VT0003635 @@ -180442,8 +281594,8 @@ def: "The quality of a chemical synaptic transmission." [AUTO:patterns/patterns/ synonym: "quality of chemical synaptic transmission" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007268 ! chemical synaptic transmission -relationship: inheres_in GO:0007268 ! chemical synaptic transmission +intersection_of: RO:0000052 GO:0007268 ! inheres in chemical synaptic transmission +relationship: RO:0000052 GO:0007268 ! inheres in chemical synaptic transmission [Term] id: OBA:VT0003641 @@ -180453,7 +281605,7 @@ synonym: "size of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001175 ! lung morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:VT0003646 @@ -180463,7 +281615,7 @@ synonym: "fatigability of muscle organ" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000079 ! muscle organ strength is_a: PATO:0001815 ! fatigability intersection_of: PATO:0001815 ! fatigability -intersection_of: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:VT0003647 @@ -180473,7 +281625,7 @@ synonym: "has number of of oligodendrocyte" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000238 ! oligodendrocyte quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000128 ! oligodendrocyte +intersection_of: RO:0000052 CL:0000128 ! inheres in oligodendrocyte [Term] id: OBA:VT0003648 @@ -180482,8 +281634,8 @@ def: "The morphology of a radial glial cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of radial glial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003634 ! glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000681 ! radial glial cell -relationship: inheres_in CL:0000681 ! radial glial cell +intersection_of: RO:0000052 CL:0000681 ! inheres in radial glial cell +relationship: RO:0000052 CL:0000681 ! inheres in radial glial cell [Term] id: OBA:VT0003650 @@ -180493,7 +281645,7 @@ synonym: "shape of kidney" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002135 ! kidney morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002113 ! kidney +intersection_of: RO:0000052 UBERON:0002113 ! inheres in kidney [Term] id: OBA:VT0003652 @@ -180503,7 +281655,7 @@ synonym: "turgor of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0002096 ! skin morphology trait is_a: PATO:0001620 ! turgor intersection_of: PATO:0001620 ! turgor -intersection_of: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:VT0003656 @@ -180513,8 +281665,8 @@ synonym: "functionality of erythrocyte" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0003194 ! cell functionality is_a: OBA:1000866 ! blood cell quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000232 ! erythrocyte -relationship: inheres_in CL:0000232 ! erythrocyte +intersection_of: RO:0000052 CL:0000232 ! inheres in erythrocyte +relationship: RO:0000052 CL:0000232 ! inheres in erythrocyte [Term] id: OBA:VT0003661 @@ -180524,8 +281676,8 @@ synonym: "morphology of locus ceruleus" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002148 ! locus ceruleus -relationship: inheres_in UBERON:0002148 ! locus ceruleus +intersection_of: RO:0000052 UBERON:0002148 ! inheres in locus ceruleus +relationship: RO:0000052 UBERON:0002148 ! inheres in locus ceruleus [Term] id: OBA:VT0003662 @@ -180534,8 +281686,8 @@ def: "The morphology of a long bone epiphyseal plate proliferative zone." [AUTO: synonym: "morphology of long bone epiphyseal plate proliferative zone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000163 ! cartilage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006771 ! long bone epiphyseal plate proliferative zone -relationship: inheres_in UBERON:0006771 ! long bone epiphyseal plate proliferative zone +intersection_of: RO:0000052 UBERON:0006771 ! inheres in long bone epiphyseal plate proliferative zone +relationship: RO:0000052 UBERON:0006771 ! inheres in long bone epiphyseal plate proliferative zone [Term] id: OBA:VT0003666 @@ -180544,8 +281696,8 @@ def: "The quality of a sperm capacitation." [AUTO:patterns/patterns/entity_attri synonym: "quality of sperm capacitation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048240 ! sperm capacitation -relationship: inheres_in GO:0048240 ! sperm capacitation +intersection_of: RO:0000052 GO:0048240 ! inheres in sperm capacitation +relationship: RO:0000052 GO:0048240 ! inheres in sperm capacitation [Term] id: OBA:VT0003668 @@ -180555,8 +281707,8 @@ synonym: "morphology of periodontium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001758 ! periodontium -relationship: inheres_in UBERON:0001758 ! periodontium +intersection_of: RO:0000052 UBERON:0001758 ! inheres in periodontium +relationship: RO:0000052 UBERON:0001758 ! inheres in periodontium [Term] id: OBA:VT0003670 @@ -180566,7 +281718,7 @@ synonym: "size of glomerular capsule" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002828 ! glomerular capsule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001230 ! glomerular capsule +intersection_of: RO:0000052 UBERON:0001230 ! inheres in glomerular capsule [Term] id: OBA:VT0003672 @@ -180575,8 +281727,8 @@ def: "The quality of a ureter development." [AUTO:patterns/patterns/entity_attri synonym: "quality of ureter development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072189 ! ureter development -relationship: inheres_in GO:0072189 ! ureter development +intersection_of: RO:0000052 GO:0072189 ! inheres in ureter development +relationship: RO:0000052 GO:0072189 ! inheres in ureter development [Term] id: OBA:VT0003673 @@ -180586,8 +281738,8 @@ synonym: "morphology of inguinal canal" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003702 ! inguinal canal -relationship: inheres_in UBERON:0003702 ! inguinal canal +intersection_of: RO:0000052 UBERON:0003702 ! inheres in inguinal canal +relationship: RO:0000052 UBERON:0003702 ! inheres in inguinal canal [Term] id: OBA:VT0003677 @@ -180597,7 +281749,7 @@ synonym: "morphology of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000403 ! lobule of pinna quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:VT0003679 @@ -180607,7 +281759,7 @@ synonym: "size of lobule of pinna" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003677 ! ear lobe morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001847 ! lobule of pinna +intersection_of: RO:0000052 UBERON:0001847 ! inheres in lobule of pinna [Term] id: OBA:VT0003684 @@ -180617,7 +281769,7 @@ synonym: "morphology of inferior olivary complex" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000759 ! inferior olivary complex quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002127 ! inferior olivary complex +intersection_of: RO:0000052 UBERON:0002127 ! inheres in inferior olivary complex [Term] id: OBA:VT0003685 @@ -180626,8 +281778,8 @@ def: "The morphology of a cardiac ganglion." [AUTO:patterns/patterns/entity_attr synonym: "morphology of cardiac ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001034 ! parasympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014463 ! cardiac ganglion -relationship: inheres_in UBERON:0014463 ! cardiac ganglion +intersection_of: RO:0000052 UBERON:0014463 ! inheres in cardiac ganglion +relationship: RO:0000052 UBERON:0014463 ! inheres in cardiac ganglion [Term] id: OBA:VT0003686 @@ -180636,8 +281788,8 @@ def: "The morphology of a eye muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of eye muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004277 ! eye muscle -relationship: inheres_in UBERON:0004277 ! eye muscle +intersection_of: RO:0000052 UBERON:0004277 ! inheres in eye muscle +relationship: RO:0000052 UBERON:0004277 ! inheres in eye muscle [Term] id: OBA:VT0003690 @@ -180647,7 +281799,7 @@ synonym: "functionality of glial cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003194 ! cell functionality is_a: OBA:1000236 ! glial cell quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000125 ! glial cell +intersection_of: RO:0000052 CL:0000125 ! inheres in glial cell [Term] id: OBA:VT0003691 @@ -180658,7 +281810,7 @@ is_a: OBA:1000564 ! microglial cell quality is_a: OBA:VT0002451 ! macrophage physiology trait is_a: OBA:VT0003690 ! glia physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000129 ! microglial cell +intersection_of: RO:0000052 CL:0000129 ! inheres in microglial cell [Term] id: OBA:VT0003696 @@ -180668,7 +281820,7 @@ synonym: "morphology of zona pellucida" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000755 ! zona pellucida quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000086 ! zona pellucida +intersection_of: RO:0000052 UBERON:0000086 ! inheres in zona pellucida [Term] id: OBA:VT0003698 @@ -180678,7 +281830,7 @@ synonym: "functionality of male reproductive system" EXACT [AUTO:patterns/patter is_a: OBA:1000521 ! male reproductive system quality is_a: OBA:VT0001919 ! reproductive system physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000079 ! male reproductive system +intersection_of: RO:0000052 UBERON:0000079 ! inheres in male reproductive system [Term] id: OBA:VT0003699 @@ -180688,7 +281840,7 @@ synonym: "functionality of female reproductive system" EXACT [AUTO:patterns/patt is_a: OBA:1000213 ! female reproductive system quality is_a: OBA:VT0001919 ! reproductive system physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000474 ! female reproductive system +intersection_of: RO:0000052 UBERON:0000474 ! inheres in female reproductive system [Term] id: OBA:VT0003703 @@ -180697,8 +281849,8 @@ def: "The morphology of a cochlear ganglion." [AUTO:patterns/patterns/entity_att synonym: "morphology of cochlear ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001081 ! cranial ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000395 ! cochlear ganglion -relationship: inheres_in UBERON:0000395 ! cochlear ganglion +intersection_of: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion +relationship: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion [Term] id: OBA:VT0003704 @@ -180707,8 +281859,8 @@ def: "The quality of a hair follicle development." [AUTO:patterns/patterns/entit synonym: "quality of hair follicle development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001942 ! hair follicle development -relationship: inheres_in GO:0001942 ! hair follicle development +intersection_of: RO:0000052 GO:0001942 ! inheres in hair follicle development +relationship: RO:0000052 GO:0001942 ! inheres in hair follicle development [Term] id: OBA:VT0003705 @@ -180717,8 +281869,8 @@ def: "The morphology of a hypodermis." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hypodermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002072 ! hypodermis -relationship: inheres_in UBERON:0002072 ! hypodermis +intersection_of: RO:0000052 UBERON:0002072 ! inheres in hypodermis +relationship: RO:0000052 UBERON:0002072 ! inheres in hypodermis [Term] id: OBA:VT0003713 @@ -180728,7 +281880,7 @@ synonym: "rotated of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002102 ! ear morphology trait is_a: PATO:0001599 ! rotated intersection_of: PATO:0001599 ! rotated -intersection_of: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:VT0003720 @@ -180738,7 +281890,7 @@ synonym: "closure of neural tube" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1001054 ! neural tube morphology is_a: PATO:0000136 ! closure intersection_of: PATO:0000136 ! closure -intersection_of: inheres_in UBERON:0001049 ! neural tube +intersection_of: RO:0000052 UBERON:0001049 ! inheres in neural tube [Term] id: OBA:VT0003722 @@ -180748,8 +281900,8 @@ synonym: "has number of of ureter" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0000056 ! ureter -relationship: inheres_in UBERON:0000056 ! ureter +intersection_of: RO:0000052 UBERON:0000056 ! inheres in ureter +relationship: RO:0000052 UBERON:0000056 ! inheres in ureter [Term] id: OBA:VT0003723 @@ -180758,8 +281910,8 @@ def: "The morphology of a long bone." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002495 ! long bone -relationship: inheres_in UBERON:0002495 ! long bone +intersection_of: RO:0000052 UBERON:0002495 ! inheres in long bone +relationship: RO:0000052 UBERON:0002495 ! inheres in long bone [Term] id: OBA:VT0003727 @@ -180769,8 +281921,8 @@ synonym: "morphology of layer of retina" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001781 ! layer of retina -relationship: inheres_in UBERON:0001781 ! layer of retina +intersection_of: RO:0000052 UBERON:0001781 ! inheres in layer of retina +relationship: RO:0000052 UBERON:0001781 ! inheres in layer of retina [Term] id: OBA:VT0003728 @@ -180779,8 +281931,8 @@ def: "The morphology of a photoreceptor layer of retina." [AUTO:patterns/pattern synonym: "morphology of photoreceptor layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001787 ! photoreceptor layer of retina -relationship: inheres_in UBERON:0001787 ! photoreceptor layer of retina +intersection_of: RO:0000052 UBERON:0001787 ! inheres in photoreceptor layer of retina +relationship: RO:0000052 UBERON:0001787 ! inheres in photoreceptor layer of retina [Term] id: OBA:VT0003729 @@ -180790,7 +281942,7 @@ synonym: "morphology of photoreceptor outer segment" EXACT [AUTO:patterns/patter is_a: OBA:1000763 ! photoreceptor outer segment quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0001750 ! photoreceptor outer segment +intersection_of: RO:0000052 GO:0001750 ! inheres in photoreceptor outer segment [Term] id: OBA:VT0003730 @@ -180800,7 +281952,7 @@ synonym: "morphology of photoreceptor inner segment" EXACT [AUTO:patterns/patter is_a: OBA:1000917 ! photoreceptor inner segment quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0001917 ! photoreceptor inner segment +intersection_of: RO:0000052 GO:0001917 ! inheres in photoreceptor inner segment [Term] id: OBA:VT0003731 @@ -180809,8 +281961,8 @@ def: "The morphology of a outer nuclear layer of retina." [AUTO:patterns/pattern synonym: "morphology of outer nuclear layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001789 ! outer nuclear layer of retina -relationship: inheres_in UBERON:0001789 ! outer nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001789 ! inheres in outer nuclear layer of retina +relationship: RO:0000052 UBERON:0001789 ! inheres in outer nuclear layer of retina [Term] id: OBA:VT0003732 @@ -180819,8 +281971,8 @@ def: "The morphology of a outer plexiform layer of retina." [AUTO:patterns/patte synonym: "morphology of outer plexiform layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001790 ! outer plexiform layer of retina -relationship: inheres_in UBERON:0001790 ! outer plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001790 ! inheres in outer plexiform layer of retina +relationship: RO:0000052 UBERON:0001790 ! inheres in outer plexiform layer of retina [Term] id: OBA:VT0003733 @@ -180829,8 +281981,8 @@ def: "The morphology of a inner nuclear layer of retina." [AUTO:patterns/pattern synonym: "morphology of inner nuclear layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001791 ! inner nuclear layer of retina -relationship: inheres_in UBERON:0001791 ! inner nuclear layer of retina +intersection_of: RO:0000052 UBERON:0001791 ! inheres in inner nuclear layer of retina +relationship: RO:0000052 UBERON:0001791 ! inheres in inner nuclear layer of retina [Term] id: OBA:VT0003734 @@ -180839,8 +281991,8 @@ def: "The morphology of a inner plexiform layer of retina." [AUTO:patterns/patte synonym: "morphology of inner plexiform layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001795 ! inner plexiform layer of retina -relationship: inheres_in UBERON:0001795 ! inner plexiform layer of retina +intersection_of: RO:0000052 UBERON:0001795 ! inheres in inner plexiform layer of retina +relationship: RO:0000052 UBERON:0001795 ! inheres in inner plexiform layer of retina [Term] id: OBA:VT0003737 @@ -180850,7 +282002,7 @@ synonym: "morphology of cartilage of external ear" EXACT [AUTO:patterns/patterns is_a: OBA:0002355 ! cartilage element morphology is_a: OBA:1000202 ! cartilage of external ear quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001867 ! cartilage of external ear +intersection_of: RO:0000052 UBERON:0001867 ! inheres in cartilage of external ear [Term] id: OBA:VT0003739 @@ -180860,7 +282012,7 @@ synonym: "size of auditory ossicle bone" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000138 ! bone element size is_a: OBA:VT0005105 ! auditory ossicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001686 ! auditory ossicle bone +intersection_of: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone [Term] id: OBA:VT0003743 @@ -180870,8 +282022,8 @@ synonym: "morphology of face" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001456 ! face -relationship: inheres_in UBERON:0001456 ! face +intersection_of: RO:0000052 UBERON:0001456 ! inheres in face +relationship: RO:0000052 UBERON:0001456 ! inheres in face [Term] id: OBA:VT0003745 @@ -180881,7 +282033,7 @@ synonym: "morphology of mouth mucosa" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000401 ! mouth mucosa quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003729 ! mouth mucosa +intersection_of: RO:0000052 UBERON:0003729 ! inheres in mouth mucosa [Term] id: OBA:VT0003749 @@ -180891,7 +282043,7 @@ synonym: "shape of mouth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000452 ! mouth morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000165 ! mouth +intersection_of: RO:0000052 UBERON:0000165 ! inheres in mouth [Term] id: OBA:VT0003755 @@ -180901,8 +282053,8 @@ synonym: "morphology of secondary palate" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001716 ! secondary palate -relationship: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate +relationship: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:VT0003756 @@ -180912,7 +282064,7 @@ synonym: "morphology of hard palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000462 ! hard palate quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003216 ! hard palate +intersection_of: RO:0000052 UBERON:0003216 ! inheres in hard palate [Term] id: OBA:VT0003759 @@ -180922,7 +282074,7 @@ synonym: "width of secondary palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002033 ! secondary palate size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:VT0003760 @@ -180932,7 +282084,7 @@ synonym: "length of secondary palate" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002033 ! secondary palate size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:VT0003763 @@ -180942,8 +282094,8 @@ synonym: "functionality of thymus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003866 ! immune organ functionality is_a: OBA:0005865 ! endocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002370 ! thymus -relationship: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus +relationship: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:VT0003764 @@ -180953,7 +282105,7 @@ synonym: "depth of secondary palate" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002033 ! secondary palate size is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0001716 ! secondary palate +intersection_of: RO:0000052 UBERON:0001716 ! inheres in secondary palate [Term] id: OBA:VT0003769 @@ -180963,7 +282115,7 @@ synonym: "morphology of lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000474 ! lip quality is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:VT0003771 @@ -180973,7 +282125,7 @@ synonym: "shape of lip" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003769 ! lip morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0001833 ! lip +intersection_of: RO:0000052 UBERON:0001833 ! inheres in lip [Term] id: OBA:VT0003791 @@ -180982,8 +282134,8 @@ def: "The morphology of a minor salivary gland." [AUTO:patterns/patterns/entity_ synonym: "morphology of minor salivary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000613 ! salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001830 ! minor salivary gland -relationship: inheres_in UBERON:0001830 ! minor salivary gland +intersection_of: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland +relationship: RO:0000052 UBERON:0001830 ! inheres in minor salivary gland [Term] id: OBA:VT0003792 @@ -180992,8 +282144,8 @@ def: "The morphology of a major salivary gland." [AUTO:patterns/patterns/entity_ synonym: "morphology of major salivary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000613 ! salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001829 ! major salivary gland -relationship: inheres_in UBERON:0001829 ! major salivary gland +intersection_of: RO:0000052 UBERON:0001829 ! inheres in major salivary gland +relationship: RO:0000052 UBERON:0001829 ! inheres in major salivary gland [Term] id: OBA:VT0003793 @@ -181002,8 +282154,8 @@ def: "The morphology of a submandibular gland." [AUTO:patterns/patterns/entity_a synonym: "morphology of submandibular gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003792 ! major salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001736 ! submandibular gland -relationship: inheres_in UBERON:0001736 ! submandibular gland +intersection_of: RO:0000052 UBERON:0001736 ! inheres in submandibular gland +relationship: RO:0000052 UBERON:0001736 ! inheres in submandibular gland [Term] id: OBA:VT0003796 @@ -181012,8 +282164,8 @@ def: "The morphology of a compact bone tissue." [AUTO:patterns/patterns/entity_a synonym: "morphology of compact bone tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001439 ! compact bone tissue -relationship: inheres_in UBERON:0001439 ! compact bone tissue +intersection_of: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue +relationship: RO:0000052 UBERON:0001439 ! inheres in compact bone tissue [Term] id: OBA:VT0003797 @@ -181022,8 +282174,8 @@ def: "The morphology of a lamellar bone." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of lamellar bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002482 ! lamellar bone -relationship: inheres_in UBERON:0002482 ! lamellar bone +intersection_of: RO:0000052 UBERON:0002482 ! inheres in lamellar bone +relationship: RO:0000052 UBERON:0002482 ! inheres in lamellar bone [Term] id: OBA:VT0003800 @@ -181033,7 +282185,7 @@ synonym: "amount of digit" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000577 ! digit quality is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002544 ! digit +intersection_of: RO:0000052 UBERON:0002544 ! inheres in digit [Term] id: OBA:VT0003806 @@ -181042,8 +282194,8 @@ def: "The quality of a nucleotide metabolic process." [AUTO:patterns/patterns/en synonym: "quality of nucleotide metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009117 ! nucleotide metabolic process -relationship: inheres_in GO:0009117 ! nucleotide metabolic process +intersection_of: RO:0000052 GO:0009117 ! inheres in nucleotide metabolic process +relationship: RO:0000052 GO:0009117 ! inheres in nucleotide metabolic process [Term] id: OBA:VT0003809 @@ -181052,8 +282204,8 @@ def: "The morphology of a hair shaft." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hair shaft" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010007 ! skin adnexa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002074 ! hair shaft -relationship: inheres_in UBERON:0002074 ! hair shaft +intersection_of: RO:0000052 UBERON:0002074 ! inheres in hair shaft +relationship: RO:0000052 UBERON:0002074 ! inheres in hair shaft [Term] id: OBA:VT0003810 @@ -181063,7 +282215,7 @@ synonym: "morphology of cuticle of hair" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000932 ! cuticle of hair quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002076 ! cuticle of hair +intersection_of: RO:0000052 UBERON:0002076 ! inheres in cuticle of hair [Term] id: OBA:VT0003811 @@ -181073,7 +282225,7 @@ synonym: "morphology of cortex of hair" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000867 ! cortex of hair quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002077 ! cortex of hair +intersection_of: RO:0000052 UBERON:0002077 ! inheres in cortex of hair [Term] id: OBA:VT0003812 @@ -181083,7 +282235,7 @@ synonym: "morphology of hair medulla" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000777 ! hair medulla quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005184 ! hair medulla +intersection_of: RO:0000052 UBERON:0005184 ! inheres in hair medulla [Term] id: OBA:VT0003815 @@ -181093,7 +282245,7 @@ synonym: "has number of of strand of hair" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000253 ! strand of hair quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT0003816 @@ -181102,8 +282254,8 @@ def: "The quality of a pituitary gland development." [AUTO:patterns/patterns/ent synonym: "quality of pituitary gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015037 ! gland development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021983 ! pituitary gland development -relationship: inheres_in GO:0021983 ! pituitary gland development +intersection_of: RO:0000052 GO:0021983 ! inheres in pituitary gland development +relationship: RO:0000052 GO:0021983 ! inheres in pituitary gland development [Term] id: OBA:VT0003817 @@ -181113,7 +282265,7 @@ synonym: "morphology of Rathke's pouch" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000758 ! Rathke's pouch quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005356 ! Rathke's pouch +intersection_of: RO:0000052 UBERON:0005356 ! inheres in Rathke's pouch [Term] id: OBA:VT0003825 @@ -181122,8 +282274,8 @@ def: "The morphology of a pillar cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of pillar cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004300 ! organ of Corti supporting cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1000191 ! pillar cell -relationship: inheres_in CL:1000191 ! pillar cell +intersection_of: RO:0000052 CL:1000191 ! inheres in pillar cell +relationship: RO:0000052 CL:1000191 ! inheres in pillar cell [Term] id: OBA:VT0003826 @@ -181133,8 +282285,8 @@ synonym: "morphology of Mullerian duct" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003890 ! Mullerian duct -relationship: inheres_in UBERON:0003890 ! Mullerian duct +intersection_of: RO:0000052 UBERON:0003890 ! inheres in Mullerian duct +relationship: RO:0000052 UBERON:0003890 ! inheres in Mullerian duct [Term] id: OBA:VT0003827 @@ -181143,8 +282295,8 @@ def: "The morphology of a mesonephric duct." [AUTO:patterns/patterns/entity_attr synonym: "morphology of mesonephric duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003074 ! mesonephric duct -relationship: inheres_in UBERON:0003074 ! mesonephric duct +intersection_of: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct +relationship: RO:0000052 UBERON:0003074 ! inheres in mesonephric duct [Term] id: OBA:VT0003840 @@ -181153,8 +282305,8 @@ def: "The morphology of a coronal suture." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of coronal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002489 ! coronal suture -relationship: inheres_in UBERON:0002489 ! coronal suture +intersection_of: RO:0000052 UBERON:0002489 ! inheres in coronal suture +relationship: RO:0000052 UBERON:0002489 ! inheres in coronal suture [Term] id: OBA:VT0003841 @@ -181163,8 +282315,8 @@ def: "The morphology of a lambdoid suture." [AUTO:patterns/patterns/entity_attri synonym: "morphology of lambdoid suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002491 ! lambdoid suture -relationship: inheres_in UBERON:0002491 ! lambdoid suture +intersection_of: RO:0000052 UBERON:0002491 ! inheres in lambdoid suture +relationship: RO:0000052 UBERON:0002491 ! inheres in lambdoid suture [Term] id: OBA:VT0003842 @@ -181173,8 +282325,8 @@ def: "The morphology of a frontal suture." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of frontal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002490 ! frontal suture -relationship: inheres_in UBERON:0002490 ! frontal suture +intersection_of: RO:0000052 UBERON:0002490 ! inheres in frontal suture +relationship: RO:0000052 UBERON:0002490 ! inheres in frontal suture [Term] id: OBA:VT0003843 @@ -181183,8 +282335,8 @@ def: "The morphology of a sagittal suture." [AUTO:patterns/patterns/entity_attri synonym: "morphology of sagittal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002492 ! sagittal suture -relationship: inheres_in UBERON:0002492 ! sagittal suture +intersection_of: RO:0000052 UBERON:0002492 ! inheres in sagittal suture +relationship: RO:0000052 UBERON:0002492 ! inheres in sagittal suture [Term] id: OBA:VT0003844 @@ -181193,8 +282345,8 @@ def: "The morphology of a squamoparietal suture." [AUTO:patterns/patterns/entity synonym: "morphology of squamoparietal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003954 ! squamoparietal suture -relationship: inheres_in UBERON:0003954 ! squamoparietal suture +intersection_of: RO:0000052 UBERON:0003954 ! inheres in squamoparietal suture +relationship: RO:0000052 UBERON:0003954 ! inheres in squamoparietal suture [Term] id: OBA:VT0003853 @@ -181211,7 +282363,7 @@ synonym: "morphology of forelimb stylopod" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000171 ! forelimb stylopod quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003822 ! forelimb stylopod +intersection_of: RO:0000052 UBERON:0003822 ! inheres in forelimb stylopod [Term] id: OBA:VT0003855 @@ -181221,8 +282373,8 @@ synonym: "morphology of forelimb zeugopod" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002386 ! forelimb zeugopod -relationship: inheres_in UBERON:0002386 ! forelimb zeugopod +intersection_of: RO:0000052 UBERON:0002386 ! inheres in forelimb zeugopod +relationship: RO:0000052 UBERON:0002386 ! inheres in forelimb zeugopod [Term] id: OBA:VT0003856 @@ -181232,8 +282384,8 @@ synonym: "morphology of hindlimb stylopod" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000376 ! hindlimb stylopod -relationship: inheres_in UBERON:0000376 ! hindlimb stylopod +intersection_of: RO:0000052 UBERON:0000376 ! inheres in hindlimb stylopod +relationship: RO:0000052 UBERON:0000376 ! inheres in hindlimb stylopod [Term] id: OBA:VT0003857 @@ -181243,7 +282395,7 @@ synonym: "morphology of hindlimb zeugopod" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000375 ! hindlimb zeugopod quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003823 ! hindlimb zeugopod +intersection_of: RO:0000052 UBERON:0003823 ! inheres in hindlimb zeugopod [Term] id: OBA:VT0003859 @@ -181252,8 +282404,8 @@ def: "The functionality of a Harderian gland." [AUTO:patterns/patterns/entity_at synonym: "functionality of Harderian gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004187 ! Harderian gland -relationship: inheres_in UBERON:0004187 ! Harderian gland +intersection_of: RO:0000052 UBERON:0004187 ! inheres in Harderian gland +relationship: RO:0000052 UBERON:0004187 ! inheres in Harderian gland [Term] id: OBA:VT0003861 @@ -181262,8 +282414,8 @@ def: "The quality of a nervous system development." [AUTO:patterns/patterns/enti synonym: "quality of nervous system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007399 ! nervous system development -relationship: inheres_in GO:0007399 ! nervous system development +intersection_of: RO:0000052 GO:0007399 ! inheres in nervous system development +relationship: RO:0000052 GO:0007399 ! inheres in nervous system development [Term] id: OBA:VT0003864 @@ -181272,8 +282424,8 @@ def: "The quality of a midbrain development." [AUTO:patterns/patterns/entity_att synonym: "quality of midbrain development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030901 ! midbrain development -relationship: inheres_in GO:0030901 ! midbrain development +intersection_of: RO:0000052 GO:0030901 ! inheres in midbrain development +relationship: RO:0000052 GO:0030901 ! inheres in midbrain development [Term] id: OBA:VT0003871 @@ -181283,8 +282435,8 @@ synonym: "morphology of entire myelin sheath" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000347 ! entire myelin sheath -relationship: inheres_in UBERON:0000347 ! entire myelin sheath +intersection_of: RO:0000052 UBERON:0000347 ! inheres in entire myelin sheath +relationship: RO:0000052 UBERON:0000347 ! inheres in entire myelin sheath [Term] id: OBA:VT0003877 @@ -181293,8 +282445,8 @@ def: "The morphology of a serotonergic neuron." [AUTO:patterns/patterns/entity_a synonym: "morphology of serotonergic neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000850 ! serotonergic neuron -relationship: inheres_in CL:0000850 ! serotonergic neuron +intersection_of: RO:0000052 CL:0000850 ! inheres in serotonergic neuron +relationship: RO:0000052 CL:0000850 ! inheres in serotonergic neuron [Term] id: OBA:VT0003878 @@ -181304,8 +282456,8 @@ synonym: "functionality of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001690 ! ear -relationship: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear +relationship: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:VT0003879 @@ -181314,8 +282466,8 @@ def: "The functionality of a sensory hair cell." [AUTO:patterns/patterns/entity_ synonym: "functionality of sensory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004983 ! sensory neuron functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000855 ! sensory hair cell -relationship: inheres_in CL:0000855 ! sensory hair cell +intersection_of: RO:0000052 CL:0000855 ! inheres in sensory hair cell +relationship: RO:0000052 CL:0000855 ! inheres in sensory hair cell [Term] id: OBA:VT0003881 @@ -181325,8 +282477,8 @@ synonym: "morphology of nephron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001285 ! nephron -relationship: inheres_in UBERON:0001285 ! nephron +intersection_of: RO:0000052 UBERON:0001285 ! inheres in nephron +relationship: RO:0000052 UBERON:0001285 ! inheres in nephron [Term] id: OBA:VT0003883 @@ -181336,7 +282488,7 @@ synonym: "size of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000470 ! stomach morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:VT0003886 @@ -181346,8 +282498,8 @@ synonym: "morphology of inner cell mass derived epiblast" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008780 ! inner cell mass derived epiblast -relationship: inheres_in UBERON:0008780 ! inner cell mass derived epiblast +intersection_of: RO:0000052 UBERON:0008780 ! inheres in inner cell mass derived epiblast +relationship: RO:0000052 UBERON:0008780 ! inheres in inner cell mass derived epiblast [Term] id: OBA:VT0003890 @@ -181357,8 +282509,8 @@ synonym: "morphology of embryonic-extraembryonic boundary" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004015 ! embryonic-extraembryonic boundary -relationship: inheres_in UBERON:0004015 ! embryonic-extraembryonic boundary +intersection_of: RO:0000052 UBERON:0004015 ! inheres in embryonic-extraembryonic boundary +relationship: RO:0000052 UBERON:0004015 ! inheres in embryonic-extraembryonic boundary [Term] id: OBA:VT0003892 @@ -181368,7 +282520,7 @@ synonym: "morphology of gastric gland" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0005862 ! exocrine gland morphology is_a: OBA:1000761 ! gastric gland quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000325 ! gastric gland +intersection_of: RO:0000052 UBERON:0000325 ! inheres in gastric gland [Term] id: OBA:VT0003893 @@ -181377,8 +282529,8 @@ def: "The quality of a hepatocyte proliferation." [AUTO:patterns/patterns/entity synonym: "quality of hepatocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072574 ! hepatocyte proliferation -relationship: inheres_in GO:0072574 ! hepatocyte proliferation +intersection_of: RO:0000052 GO:0072574 ! inheres in hepatocyte proliferation +relationship: RO:0000052 GO:0072574 ! inheres in hepatocyte proliferation [Term] id: OBA:VT0003920 @@ -181388,7 +282540,7 @@ synonym: "morphology of heart right ventricle" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000280 ! heart right ventricle quality is_a: OBA:VT0005294 ! heart ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:VT0003921 @@ -181398,7 +282550,7 @@ synonym: "morphology of heart left ventricle" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000229 ! heart left ventricle quality is_a: OBA:VT0005294 ! heart ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:VT0003932 @@ -181408,8 +282560,8 @@ synonym: "morphology of molar crown" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003955 ! molar crown -relationship: inheres_in UBERON:0003955 ! molar crown +intersection_of: RO:0000052 UBERON:0003955 ! inheres in molar crown +relationship: RO:0000052 UBERON:0003955 ! inheres in molar crown [Term] id: OBA:VT0003933 @@ -181419,7 +282571,7 @@ synonym: "morphology of cementum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0003889 ! odontoid tissue morphology is_a: OBA:1000643 ! cementum quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001753 ! cementum +intersection_of: RO:0000052 UBERON:0001753 ! inheres in cementum [Term] id: OBA:VT0003934 @@ -181428,8 +282580,8 @@ def: "The quality of a pancreas development." [AUTO:patterns/patterns/entity_att synonym: "quality of pancreas development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0031016 ! pancreas development -relationship: inheres_in GO:0031016 ! pancreas development +intersection_of: RO:0000052 GO:0031016 ! inheres in pancreas development +relationship: RO:0000052 GO:0031016 ! inheres in pancreas development [Term] id: OBA:VT0003936 @@ -181438,8 +282590,8 @@ def: "The quality of a reproductive system development." [AUTO:patterns/patterns synonym: "quality of reproductive system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061458 ! reproductive system development -relationship: inheres_in GO:0061458 ! reproductive system development +intersection_of: RO:0000052 GO:0061458 ! inheres in reproductive system development +relationship: RO:0000052 GO:0061458 ! inheres in reproductive system development [Term] id: OBA:VT0003938 @@ -181448,8 +282600,8 @@ def: "The quality of a ear development." [AUTO:patterns/patterns/entity_attribut synonym: "quality of ear development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043583 ! ear development -relationship: inheres_in GO:0043583 ! ear development +intersection_of: RO:0000052 GO:0043583 ! inheres in ear development +relationship: RO:0000052 GO:0043583 ! inheres in ear development [Term] id: OBA:VT0003939 @@ -181459,8 +282611,8 @@ synonym: "morphology of myotome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003082 ! myotome -relationship: inheres_in UBERON:0003082 ! myotome +intersection_of: RO:0000052 UBERON:0003082 ! inheres in myotome +relationship: RO:0000052 UBERON:0003082 ! inheres in myotome [Term] id: OBA:VT0003940 @@ -181470,8 +282622,8 @@ synonym: "morphology of dermatome" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004016 ! dermatome -relationship: inheres_in UBERON:0004016 ! dermatome +intersection_of: RO:0000052 UBERON:0004016 ! inheres in dermatome +relationship: RO:0000052 UBERON:0004016 ! inheres in dermatome [Term] id: OBA:VT0003941 @@ -181480,8 +282632,8 @@ def: "The quality of a skin development." [AUTO:patterns/patterns/entity_attribu synonym: "quality of skin development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043588 ! skin development -relationship: inheres_in GO:0043588 ! skin development +intersection_of: RO:0000052 GO:0043588 ! inheres in skin development +relationship: RO:0000052 GO:0043588 ! inheres in skin development [Term] id: OBA:VT0003943 @@ -181490,8 +282642,8 @@ def: "The quality of a hepaticobiliary system development." [AUTO:patterns/patte synonym: "quality of hepaticobiliary system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061008 ! hepaticobiliary system development -relationship: inheres_in GO:0061008 ! hepaticobiliary system development +intersection_of: RO:0000052 GO:0061008 ! inheres in hepaticobiliary system development +relationship: RO:0000052 GO:0061008 ! inheres in hepaticobiliary system development [Term] id: OBA:VT0003945 @@ -181500,8 +282652,8 @@ def: "The functionality of a lymphocyte." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002442 ! leukocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000542 ! lymphocyte -relationship: inheres_in CL:0000542 ! lymphocyte +intersection_of: RO:0000052 CL:0000542 ! inheres in lymphocyte +relationship: RO:0000052 CL:0000542 ! inheres in lymphocyte [Term] id: OBA:VT0003947 @@ -181510,8 +282662,8 @@ def: "The amount of a cholesterol." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of cholesterol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000973 ! sterol amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:16113 ! cholesterol -relationship: inheres_in CHEBI:16113 ! cholesterol +intersection_of: RO:0000052 CHEBI:16113 ! inheres in cholesterol +relationship: RO:0000052 CHEBI:16113 ! inheres in cholesterol [Term] id: OBA:VT0003949 @@ -181528,8 +282680,8 @@ synonym: "amount of copper(0)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:30052 ! copper(0) -relationship: inheres_in CHEBI:30052 ! copper(0) +intersection_of: RO:0000052 CHEBI:30052 ! inheres in copper(0) +relationship: RO:0000052 CHEBI:30052 ! inheres in copper(0) [Term] id: OBA:VT0003954 @@ -181539,8 +282691,8 @@ synonym: "morphology of Reichert's membrane" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004369 ! Reichert's membrane -relationship: inheres_in UBERON:0004369 ! Reichert's membrane +intersection_of: RO:0000052 UBERON:0004369 ! inheres in Reichert's membrane +relationship: RO:0000052 UBERON:0004369 ! inheres in Reichert's membrane [Term] id: OBA:VT0003955 @@ -181549,8 +282701,8 @@ def: "The morphology of a ultimobranchial body." [AUTO:patterns/patterns/entity_ synonym: "morphology of ultimobranchial body" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005864 ! endocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003092 ! ultimobranchial body -relationship: inheres_in UBERON:0003092 ! ultimobranchial body +intersection_of: RO:0000052 UBERON:0003092 ! inheres in ultimobranchial body +relationship: RO:0000052 UBERON:0003092 ! inheres in ultimobranchial body [Term] id: OBA:VT0003974 @@ -181559,8 +282711,8 @@ def: "The morphology of a endocardium." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of endocardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002165 ! endocardium -relationship: inheres_in UBERON:0002165 ! endocardium +intersection_of: RO:0000052 UBERON:0002165 ! inheres in endocardium +relationship: RO:0000052 UBERON:0002165 ! inheres in endocardium [Term] id: OBA:VT0003977 @@ -181577,7 +282729,7 @@ synonym: "growth rate of embryo" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000069 ! embryo trait is_a: PATO:0001492 ! growth rate intersection_of: PATO:0001492 ! growth rate -intersection_of: inheres_in UBERON:0000922 ! embryo +intersection_of: RO:0000052 UBERON:0000922 ! inheres in embryo [Term] id: OBA:VT0003986 @@ -181587,7 +282739,7 @@ synonym: "size of cochlear ganglion" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003703 ! vestibulocochlear ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000395 ! cochlear ganglion +intersection_of: RO:0000052 UBERON:0000395 ! inheres in cochlear ganglion [Term] id: OBA:VT0003987 @@ -181597,7 +282749,7 @@ synonym: "size of vestibular ganglion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002856 ! vestibular ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002824 ! vestibular ganglion +intersection_of: RO:0000052 UBERON:0002824 ! inheres in vestibular ganglion [Term] id: OBA:VT0003989 @@ -181607,8 +282759,8 @@ synonym: "morphology of barrel cortex" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010415 ! barrel cortex -relationship: inheres_in UBERON:0010415 ! barrel cortex +intersection_of: RO:0000052 UBERON:0010415 ! inheres in barrel cortex +relationship: RO:0000052 UBERON:0010415 ! inheres in barrel cortex [Term] id: OBA:VT0003993 @@ -181618,8 +282770,8 @@ synonym: "morphology of ventral root of spinal cord" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002260 ! ventral root of spinal cord -relationship: inheres_in UBERON:0002260 ! ventral root of spinal cord +intersection_of: RO:0000052 UBERON:0002260 ! inheres in ventral root of spinal cord +relationship: RO:0000052 UBERON:0002260 ! inheres in ventral root of spinal cord [Term] id: OBA:VT0003994 @@ -181629,8 +282781,8 @@ synonym: "morphology of dorsal root of spinal cord" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002261 ! dorsal root of spinal cord -relationship: inheres_in UBERON:0002261 ! dorsal root of spinal cord +intersection_of: RO:0000052 UBERON:0002261 ! inheres in dorsal root of spinal cord +relationship: RO:0000052 UBERON:0002261 ! inheres in dorsal root of spinal cord [Term] id: OBA:VT0004002 @@ -181640,8 +282792,8 @@ synonym: "morphology of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002115 ! jejunum -relationship: inheres_in UBERON:0002115 ! jejunum +intersection_of: RO:0000052 UBERON:0002115 ! inheres in jejunum +relationship: RO:0000052 UBERON:0002115 ! inheres in jejunum [Term] id: OBA:VT0004005 @@ -181650,8 +282802,8 @@ def: "The contractility of a intestine smooth muscle." [AUTO:patterns/patterns/e synonym: "contractility of intestine smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000740 ! smooth muscle contractility trait intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0004221 ! intestine smooth muscle -relationship: inheres_in UBERON:0004221 ! intestine smooth muscle +intersection_of: RO:0000052 UBERON:0004221 ! inheres in intestine smooth muscle +relationship: RO:0000052 UBERON:0004221 ! inheres in intestine smooth muscle [Term] id: OBA:VT0004006 @@ -181661,8 +282813,8 @@ synonym: "contractility of muscle layer of jejunum" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0012377 ! muscle layer of jejunum -relationship: inheres_in UBERON:0012377 ! muscle layer of jejunum +intersection_of: RO:0000052 UBERON:0012377 ! inheres in muscle layer of jejunum +relationship: RO:0000052 UBERON:0012377 ! inheres in muscle layer of jejunum [Term] id: OBA:VT0004007 @@ -181671,8 +282823,8 @@ def: "The morphology of a lung blood vessel." [AUTO:patterns/patterns/entity_att synonym: "morphology of lung blood vessel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003512 ! lung blood vessel -relationship: inheres_in UBERON:0003512 ! lung blood vessel +intersection_of: RO:0000052 UBERON:0003512 ! inheres in lung blood vessel +relationship: RO:0000052 UBERON:0003512 ! inheres in lung blood vessel [Term] id: OBA:VT0004020 @@ -181682,7 +282834,7 @@ synonym: "volume of amniotic fluid" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000263 ! amniotic fluid quality is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0000173 ! amniotic fluid +intersection_of: RO:0000052 UBERON:0000173 ! inheres in amniotic fluid [Term] id: OBA:VT0004032 @@ -181691,8 +282843,8 @@ def: "The morphology of a interventricular groove." [AUTO:patterns/patterns/enti synonym: "morphology of interventricular groove" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005455 ! interventricular groove -relationship: inheres_in UBERON:0005455 ! interventricular groove +intersection_of: RO:0000052 UBERON:0005455 ! inheres in interventricular groove +relationship: RO:0000052 UBERON:0005455 ! inheres in interventricular groove [Term] id: OBA:VT0004035 @@ -181701,8 +282853,8 @@ def: "The morphology of a sublingual gland." [AUTO:patterns/patterns/entity_attr synonym: "morphology of sublingual gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003792 ! major salivary gland morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001832 ! sublingual gland -relationship: inheres_in UBERON:0001832 ! sublingual gland +intersection_of: RO:0000052 UBERON:0001832 ! inheres in sublingual gland +relationship: RO:0000052 UBERON:0001832 ! inheres in sublingual gland [Term] id: OBA:VT0004043 @@ -181711,8 +282863,8 @@ def: "The quality of a regulation of pH." [AUTO:patterns/patterns/entity_attribu synonym: "quality of regulation of pH" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000500 ! monovalent inorganic cation homeostasis quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006885 ! regulation of pH -relationship: inheres_in GO:0006885 ! regulation of pH +intersection_of: RO:0000052 GO:0006885 ! inheres in regulation of pH +relationship: RO:0000052 GO:0006885 ! inheres in regulation of pH [Term] id: OBA:VT0004047 @@ -181722,8 +282874,8 @@ synonym: "composition of milk" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000000 ! mammary gland secreted fluid morphology trait is_a: PATO:0000025 ! composition intersection_of: PATO:0000025 ! composition -intersection_of: inheres_in UBERON:0001913 ! milk -relationship: inheres_in UBERON:0001913 ! milk +intersection_of: RO:0000052 UBERON:0001913 ! inheres in milk +relationship: RO:0000052 UBERON:0001913 ! inheres in milk [Term] id: OBA:VT0004054 @@ -181732,8 +282884,8 @@ def: "The morphology of a periocular mesenchyme." [AUTO:patterns/patterns/entity synonym: "morphology of periocular mesenchyme" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004017 ! periocular mesenchyme -relationship: inheres_in UBERON:0004017 ! periocular mesenchyme +intersection_of: RO:0000052 UBERON:0004017 ! inheres in periocular mesenchyme +relationship: RO:0000052 UBERON:0004017 ! inheres in periocular mesenchyme [Term] id: OBA:VT0004062 @@ -181743,7 +282895,7 @@ synonym: "volume of right cardiac atrium" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000005 ! right atrium size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002078 ! right cardiac atrium +intersection_of: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium [Term] id: OBA:VT0004063 @@ -181753,7 +282905,7 @@ synonym: "volume of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000012 ! left atrium size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:VT0004066 @@ -181763,8 +282915,8 @@ synonym: "morphology of primitive knot" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003062 ! primitive knot -relationship: inheres_in UBERON:0003062 ! primitive knot +intersection_of: RO:0000052 UBERON:0003062 ! inheres in primitive knot +relationship: RO:0000052 UBERON:0003062 ! inheres in primitive knot [Term] id: OBA:VT0004069 @@ -181774,8 +282926,8 @@ synonym: "morphology of muscle spindle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003718 ! muscle spindle -relationship: inheres_in UBERON:0003718 ! muscle spindle +intersection_of: RO:0000052 UBERON:0003718 ! inheres in muscle spindle +relationship: RO:0000052 UBERON:0003718 ! inheres in muscle spindle [Term] id: OBA:VT0004074 @@ -181784,8 +282936,8 @@ def: "The morphology of a Schwann cell precursor." [AUTO:patterns/patterns/entit synonym: "morphology of Schwann cell precursor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002375 ! Schwann cell precursor -relationship: inheres_in CL:0002375 ! Schwann cell precursor +intersection_of: RO:0000052 CL:0002375 ! inheres in Schwann cell precursor +relationship: RO:0000052 CL:0002375 ! inheres in Schwann cell precursor [Term] id: OBA:VT0004075 @@ -181795,8 +282947,8 @@ synonym: "amount of Schwann cell precursor" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002375 ! Schwann cell precursor -relationship: inheres_in CL:0002375 ! Schwann cell precursor +intersection_of: RO:0000052 CL:0002375 ! inheres in Schwann cell precursor +relationship: RO:0000052 CL:0002375 ! inheres in Schwann cell precursor [Term] id: OBA:VT0004077 @@ -181806,7 +282958,7 @@ synonym: "morphology of striatum" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000185 ! striatum quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002435 ! striatum +intersection_of: RO:0000052 UBERON:0002435 ! inheres in striatum [Term] id: OBA:VT0004078 @@ -181816,8 +282968,8 @@ synonym: "morphology of caudate nucleus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001873 ! caudate nucleus -relationship: inheres_in UBERON:0001873 ! caudate nucleus +intersection_of: RO:0000052 UBERON:0001873 ! inheres in caudate nucleus +relationship: RO:0000052 UBERON:0001873 ! inheres in caudate nucleus [Term] id: OBA:VT0004079 @@ -181827,8 +282979,8 @@ synonym: "morphology of putamen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001874 ! putamen -relationship: inheres_in UBERON:0001874 ! putamen +intersection_of: RO:0000052 UBERON:0001874 ! inheres in putamen +relationship: RO:0000052 UBERON:0001874 ! inheres in putamen [Term] id: OBA:VT0004080 @@ -181838,8 +282990,8 @@ synonym: "morphology of nucleus accumbens" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001882 ! nucleus accumbens -relationship: inheres_in UBERON:0001882 ! nucleus accumbens +intersection_of: RO:0000052 UBERON:0001882 ! inheres in nucleus accumbens +relationship: RO:0000052 UBERON:0001882 ! inheres in nucleus accumbens [Term] id: OBA:VT0004081 @@ -181849,8 +283001,8 @@ synonym: "morphology of globus pallidus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001875 ! globus pallidus -relationship: inheres_in UBERON:0001875 ! globus pallidus +intersection_of: RO:0000052 UBERON:0001875 ! inheres in globus pallidus +relationship: RO:0000052 UBERON:0001875 ! inheres in globus pallidus [Term] id: OBA:VT0004082 @@ -181860,8 +283012,8 @@ synonym: "morphology of habenula" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001904 ! habenula -relationship: inheres_in UBERON:0001904 ! habenula +intersection_of: RO:0000052 UBERON:0001904 ! inheres in habenula +relationship: RO:0000052 UBERON:0001904 ! inheres in habenula [Term] id: OBA:VT0004087 @@ -181870,8 +283022,8 @@ def: "The morphology of a muscle cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000187 ! muscle cell -relationship: inheres_in CL:0000187 ! muscle cell +intersection_of: RO:0000052 CL:0000187 ! inheres in muscle cell +relationship: RO:0000052 CL:0000187 ! inheres in muscle cell [Term] id: OBA:VT0004088 @@ -181880,8 +283032,8 @@ def: "The morphology of a sarcoplasmic reticulum." [AUTO:patterns/patterns/entit synonym: "morphology of sarcoplasmic reticulum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004707 ! endoplasmic reticulum morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0016529 ! sarcoplasmic reticulum -relationship: inheres_in GO:0016529 ! sarcoplasmic reticulum +intersection_of: RO:0000052 GO:0016529 ! inheres in sarcoplasmic reticulum +relationship: RO:0000052 GO:0016529 ! inheres in sarcoplasmic reticulum [Term] id: OBA:VT0004090 @@ -181891,8 +283043,8 @@ synonym: "morphology of sarcomere" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030017 ! sarcomere -relationship: inheres_in GO:0030017 ! sarcomere +intersection_of: RO:0000052 GO:0030017 ! inheres in sarcomere +relationship: RO:0000052 GO:0030017 ! inheres in sarcomere [Term] id: OBA:VT0004091 @@ -181902,7 +283054,7 @@ synonym: "morphology of Z disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000701 ! Z disc quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030018 ! Z disc +intersection_of: RO:0000052 GO:0030018 ! inheres in Z disc [Term] id: OBA:VT0004093 @@ -181912,7 +283064,7 @@ synonym: "spatial pattern of Z disc" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0004091 ! Z line morphology trait is_a: PATO:0000060 ! spatial pattern intersection_of: PATO:0000060 ! spatial pattern -intersection_of: inheres_in GO:0030018 ! Z disc +intersection_of: RO:0000052 GO:0030018 ! inheres in Z disc [Term] id: OBA:VT0004094 @@ -181922,7 +283074,7 @@ synonym: "morphology of M band" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000882 ! M band quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0031430 ! M band +intersection_of: RO:0000052 GO:0031430 ! inheres in M band [Term] id: OBA:VT0004095 @@ -181931,8 +283083,8 @@ def: "The morphology of a eyelash." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of eyelash" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000367 ! coat/hair morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001702 ! eyelash -relationship: inheres_in UBERON:0001702 ! eyelash +intersection_of: RO:0000052 UBERON:0001702 ! inheres in eyelash +relationship: RO:0000052 UBERON:0001702 ! inheres in eyelash [Term] id: OBA:VT0004096 @@ -181941,8 +283093,8 @@ def: "The quality of a midbrain-hindbrain boundary development." [AUTO:patterns/ synonym: "quality of midbrain-hindbrain boundary development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030917 ! midbrain-hindbrain boundary development -relationship: inheres_in GO:0030917 ! midbrain-hindbrain boundary development +intersection_of: RO:0000052 GO:0030917 ! inheres in midbrain-hindbrain boundary development +relationship: RO:0000052 GO:0030917 ! inheres in midbrain-hindbrain boundary development [Term] id: OBA:VT0004097 @@ -181952,8 +283104,8 @@ synonym: "morphology of cerebellar cortex" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002129 ! cerebellar cortex -relationship: inheres_in UBERON:0002129 ! cerebellar cortex +intersection_of: RO:0000052 UBERON:0002129 ! inheres in cerebellar cortex +relationship: RO:0000052 UBERON:0002129 ! inheres in cerebellar cortex [Term] id: OBA:VT0004098 @@ -181961,10 +283113,11 @@ name: cerebellar granule cell morphology trait def: "The morphology of a cerebellar granule cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of cerebellar granule cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000922 ! granule cell quality +is_a: OBA:VT0002181 ! brain cell morphology trait is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0001031 ! cerebellar granule cell -relationship: inheres_in CL:0001031 ! cerebellar granule cell +intersection_of: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell +relationship: RO:0000052 CL:0001031 ! inheres in cerebellar granule cell [Term] id: OBA:VT0004099 @@ -181974,8 +283127,8 @@ synonym: "morphology of cerebellar glomerulus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011915 ! cerebellar glomerulus -relationship: inheres_in UBERON:0011915 ! cerebellar glomerulus +intersection_of: RO:0000052 UBERON:0011915 ! inheres in cerebellar glomerulus +relationship: RO:0000052 UBERON:0011915 ! inheres in cerebellar glomerulus [Term] id: OBA:VT0004100 @@ -181984,8 +283137,8 @@ def: "The morphology of a spinal cord interneuron." [AUTO:patterns/patterns/enti synonym: "morphology of spinal cord interneuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006004 ! interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0005000 ! spinal cord interneuron -relationship: inheres_in CL:0005000 ! spinal cord interneuron +intersection_of: RO:0000052 CL:0005000 ! inheres in spinal cord interneuron +relationship: RO:0000052 CL:0005000 ! inheres in spinal cord interneuron [Term] id: OBA:VT0004101 @@ -182003,8 +283156,8 @@ synonym: "morphology of caudate-putamen" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005383 ! caudate-putamen -relationship: inheres_in UBERON:0005383 ! caudate-putamen +intersection_of: RO:0000052 UBERON:0005383 ! inheres in caudate-putamen +relationship: RO:0000052 UBERON:0005383 ! inheres in caudate-putamen [Term] id: OBA:VT0004103 @@ -182014,8 +283167,8 @@ synonym: "morphology of ventral striatum" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005403 ! ventral striatum -relationship: inheres_in UBERON:0005403 ! ventral striatum +intersection_of: RO:0000052 UBERON:0005403 ! inheres in ventral striatum +relationship: RO:0000052 UBERON:0005403 ! inheres in ventral striatum [Term] id: OBA:VT0004104 @@ -182025,7 +283178,7 @@ synonym: "shape of camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0002092 ! eye morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:VT0004107 @@ -182034,8 +283187,8 @@ def: "The morphology of a thoracic duct." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of thoracic duct" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001879 ! lymphatic vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001631 ! thoracic duct -relationship: inheres_in UBERON:0001631 ! thoracic duct +intersection_of: RO:0000052 UBERON:0001631 ! inheres in thoracic duct +relationship: RO:0000052 UBERON:0001631 ! inheres in thoracic duct [Term] id: OBA:VT0004109 @@ -182044,8 +283197,8 @@ def: "The quality of a Sertoli cell development." [AUTO:patterns/patterns/entity synonym: "quality of Sertoli cell development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060009 ! Sertoli cell development -relationship: inheres_in GO:0060009 ! Sertoli cell development +intersection_of: RO:0000052 GO:0060009 ! inheres in Sertoli cell development +relationship: RO:0000052 GO:0060009 ! inheres in Sertoli cell development [Term] id: OBA:VT0004111 @@ -182055,8 +283208,8 @@ synonym: "morphology of coronary artery" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005089 ! coronary vessel morphology is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001621 ! coronary artery -relationship: inheres_in UBERON:0001621 ! coronary artery +intersection_of: RO:0000052 UBERON:0001621 ! inheres in coronary artery +relationship: RO:0000052 UBERON:0001621 ! inheres in coronary artery [Term] id: OBA:VT0004113 @@ -182066,8 +283219,8 @@ synonym: "morphology of pharyngeal arch artery" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002191 ! artery morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004363 ! pharyngeal arch artery -relationship: inheres_in UBERON:0004363 ! pharyngeal arch artery +intersection_of: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery +relationship: RO:0000052 UBERON:0004363 ! inheres in pharyngeal arch artery [Term] id: OBA:VT0004114 @@ -182076,8 +283229,8 @@ def: "The morphology of a atrioventricular node." [AUTO:patterns/patterns/entity synonym: "morphology of atrioventricular node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002352 ! atrioventricular node -relationship: inheres_in UBERON:0002352 ! atrioventricular node +intersection_of: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node +relationship: RO:0000052 UBERON:0002352 ! inheres in atrioventricular node [Term] id: OBA:VT0004115 @@ -182086,8 +283239,8 @@ def: "The morphology of a sinoatrial node." [AUTO:patterns/patterns/entity_attri synonym: "morphology of sinoatrial node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002351 ! sinoatrial node -relationship: inheres_in UBERON:0002351 ! sinoatrial node +intersection_of: RO:0000052 UBERON:0002351 ! inheres in sinoatrial node +relationship: RO:0000052 UBERON:0002351 ! inheres in sinoatrial node [Term] id: OBA:VT0004117 @@ -182096,8 +283249,8 @@ def: "The morphology of a bundle of His." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of bundle of His" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002353 ! bundle of His -relationship: inheres_in UBERON:0002353 ! bundle of His +intersection_of: RO:0000052 UBERON:0002353 ! inheres in bundle of His +relationship: RO:0000052 UBERON:0002353 ! inheres in bundle of His [Term] id: OBA:VT0004118 @@ -182107,8 +283260,8 @@ synonym: "morphology of baroreceptor" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004019 ! baroreceptor -relationship: inheres_in UBERON:0004019 ! baroreceptor +intersection_of: RO:0000052 UBERON:0004019 ! inheres in baroreceptor +relationship: RO:0000052 UBERON:0004019 ! inheres in baroreceptor [Term] id: OBA:VT0004121 @@ -182117,8 +283270,8 @@ def: "The morphology of a sarcolemma." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of sarcolemma" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000089 ! plasma membrane morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0042383 ! sarcolemma -relationship: inheres_in GO:0042383 ! sarcolemma +intersection_of: RO:0000052 GO:0042383 ! inheres in sarcolemma +relationship: RO:0000052 GO:0042383 ! inheres in sarcolemma [Term] id: OBA:VT0004123 @@ -182127,8 +283280,8 @@ def: "The morphology of a conducting system of heart." [AUTO:patterns/patterns/e synonym: "morphology of conducting system of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002350 ! conducting system of heart -relationship: inheres_in UBERON:0002350 ! conducting system of heart +intersection_of: RO:0000052 UBERON:0002350 ! inheres in conducting system of heart +relationship: RO:0000052 UBERON:0002350 ! inheres in conducting system of heart [Term] id: OBA:VT0004124 @@ -182137,8 +283290,8 @@ def: "The morphology of a cardiac Purkinje fiber." [AUTO:patterns/patterns/entit synonym: "morphology of cardiac Purkinje fiber" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005129 ! cardiac muscle tissue of myocardium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002354 ! cardiac Purkinje fiber -relationship: inheres_in UBERON:0002354 ! cardiac Purkinje fiber +intersection_of: RO:0000052 UBERON:0002354 ! inheres in cardiac Purkinje fiber +relationship: RO:0000052 UBERON:0002354 ! inheres in cardiac Purkinje fiber [Term] id: OBA:VT0004127 @@ -182148,7 +283301,7 @@ synonym: "thickness of hypodermis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0003916 ! hypodermis size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002072 ! hypodermis +intersection_of: RO:0000052 UBERON:0002072 ! inheres in hypodermis [Term] id: OBA:VT0004128 @@ -182157,8 +283310,8 @@ def: "The morphology of a fat cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of fat cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000136 ! fat cell -relationship: inheres_in CL:0000136 ! fat cell +intersection_of: RO:0000052 CL:0000136 ! inheres in fat cell +relationship: RO:0000052 CL:0000136 ! inheres in fat cell [Term] id: OBA:VT0004134 @@ -182168,7 +283321,7 @@ synonym: "morphology of thoracic segment of trunk" EXACT [AUTO:patterns/patterns is_a: OBA:VT0015059 ! thorax trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000915 ! thoracic segment of trunk +intersection_of: RO:0000052 UBERON:0000915 ! inheres in thoracic segment of trunk [Term] id: OBA:VT0004136 @@ -182178,7 +283331,7 @@ synonym: "morphology of tongue muscle" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003692 ! muscle organ morphology is_a: OBA:1000261 ! tongue muscle quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000378 ! tongue muscle +intersection_of: RO:0000052 UBERON:0000378 ! inheres in tongue muscle [Term] id: OBA:VT0004138 @@ -182187,8 +283340,8 @@ def: "The morphology of a mucous neck cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of mucous neck cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000651 ! mucous neck cell -relationship: inheres_in CL:0000651 ! mucous neck cell +intersection_of: RO:0000052 CL:0000651 ! inheres in mucous neck cell +relationship: RO:0000052 CL:0000651 ! inheres in mucous neck cell [Term] id: OBA:VT0004140 @@ -182197,8 +283350,8 @@ def: "The morphology of a chief cell of parathyroid gland." [AUTO:patterns/patte synonym: "morphology of chief cell of parathyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000446 ! chief cell of parathyroid gland -relationship: inheres_in CL:0000446 ! chief cell of parathyroid gland +intersection_of: RO:0000052 CL:0000446 ! inheres in chief cell of parathyroid gland +relationship: RO:0000052 CL:0000446 ! inheres in chief cell of parathyroid gland [Term] id: OBA:VT0004141 @@ -182207,8 +283360,8 @@ def: "The morphology of a enteroendocrine cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of enteroendocrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000164 ! enteroendocrine cell -relationship: inheres_in CL:0000164 ! enteroendocrine cell +intersection_of: RO:0000052 CL:0000164 ! inheres in enteroendocrine cell +relationship: RO:0000052 CL:0000164 ! inheres in enteroendocrine cell [Term] id: OBA:VT0004142 @@ -182218,7 +283371,7 @@ synonym: "tonicity of muscle organ" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0004162 ! muscle organ contractility is_a: PATO:0001439 ! tonicity intersection_of: PATO:0001439 ! tonicity -intersection_of: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:VT0004147 @@ -182227,8 +283380,8 @@ def: "The amount of a porphyrin." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of porphyrin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:8337 ! porphyrin -relationship: inheres_in CHEBI:8337 ! porphyrin +intersection_of: RO:0000052 CHEBI:8337 ! inheres in porphyrin +relationship: RO:0000052 CHEBI:8337 ! inheres in porphyrin [Term] id: OBA:VT0004152 @@ -182245,8 +283398,8 @@ synonym: "morphology of mammillary body" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002206 ! mammillary body -relationship: inheres_in UBERON:0002206 ! mammillary body +intersection_of: RO:0000052 UBERON:0002206 ! inheres in mammillary body +relationship: RO:0000052 UBERON:0002206 ! inheres in mammillary body [Term] id: OBA:VT0004163 @@ -182256,7 +283409,7 @@ synonym: "morphology of adenohypophysis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000303 ! adenohypophysis quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002196 ! adenohypophysis +intersection_of: RO:0000052 UBERON:0002196 ! inheres in adenohypophysis [Term] id: OBA:VT0004164 @@ -182266,7 +283419,7 @@ synonym: "morphology of neurohypophysis" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0005867 ! secretory circumventricular organ morphology is_a: OBA:1000426 ! neurohypophysis quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002198 ! neurohypophysis +intersection_of: RO:0000052 UBERON:0002198 ! inheres in neurohypophysis [Term] id: OBA:VT0004165 @@ -182276,8 +283429,8 @@ synonym: "morphology of lateral geniculate body" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001926 ! lateral geniculate body -relationship: inheres_in UBERON:0001926 ! lateral geniculate body +intersection_of: RO:0000052 UBERON:0001926 ! inheres in lateral geniculate body +relationship: RO:0000052 UBERON:0001926 ! inheres in lateral geniculate body [Term] id: OBA:VT0004166 @@ -182287,8 +283440,8 @@ synonym: "morphology of limbic system" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000349 ! limbic system -relationship: inheres_in UBERON:0000349 ! limbic system +intersection_of: RO:0000052 UBERON:0000349 ! inheres in limbic system +relationship: RO:0000052 UBERON:0000349 ! inheres in limbic system [Term] id: OBA:VT0004167 @@ -182298,8 +283451,8 @@ synonym: "morphology of cingulate gyrus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002967 ! cingulate gyrus -relationship: inheres_in UBERON:0002967 ! cingulate gyrus +intersection_of: RO:0000052 UBERON:0002967 ! inheres in cingulate gyrus +relationship: RO:0000052 UBERON:0002967 ! inheres in cingulate gyrus [Term] id: OBA:VT0004168 @@ -182309,8 +283462,8 @@ synonym: "morphology of parahippocampal gyrus" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002973 ! parahippocampal gyrus -relationship: inheres_in UBERON:0002973 ! parahippocampal gyrus +intersection_of: RO:0000052 UBERON:0002973 ! inheres in parahippocampal gyrus +relationship: RO:0000052 UBERON:0002973 ! inheres in parahippocampal gyrus [Term] id: OBA:VT0004169 @@ -182320,8 +283473,8 @@ synonym: "morphology of limbic lobe" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002600 ! limbic lobe -relationship: inheres_in UBERON:0002600 ! limbic lobe +intersection_of: RO:0000052 UBERON:0002600 ! inheres in limbic lobe +relationship: RO:0000052 UBERON:0002600 ! inheres in limbic lobe [Term] id: OBA:VT0004170 @@ -182331,8 +283484,8 @@ synonym: "morphology of orbitofrontal cortex" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004167 ! orbitofrontal cortex -relationship: inheres_in UBERON:0004167 ! orbitofrontal cortex +intersection_of: RO:0000052 UBERON:0004167 ! inheres in orbitofrontal cortex +relationship: RO:0000052 UBERON:0004167 ! inheres in orbitofrontal cortex [Term] id: OBA:VT0004171 @@ -182341,8 +283494,8 @@ def: "The quality of a pallium development." [AUTO:patterns/patterns/entity_attr synonym: "quality of pallium development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021543 ! pallium development -relationship: inheres_in GO:0021543 ! pallium development +intersection_of: RO:0000052 GO:0021543 ! inheres in pallium development +relationship: RO:0000052 GO:0021543 ! inheres in pallium development [Term] id: OBA:VT0004172 @@ -182351,8 +283504,8 @@ def: "The quality of a subpallium development." [AUTO:patterns/patterns/entity_a synonym: "quality of subpallium development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0021544 ! subpallium development -relationship: inheres_in GO:0021544 ! subpallium development +intersection_of: RO:0000052 GO:0021544 ! inheres in subpallium development +relationship: RO:0000052 GO:0021544 ! inheres in subpallium development [Term] id: OBA:VT0004173 @@ -182361,8 +283514,8 @@ def: "The morphology of a intervertebral disk." [AUTO:patterns/patterns/entity_a synonym: "morphology of intervertebral disk" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001066 ! intervertebral disk -relationship: inheres_in UBERON:0001066 ! intervertebral disk +intersection_of: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk +relationship: RO:0000052 UBERON:0001066 ! inheres in intervertebral disk [Term] id: OBA:VT0004174 @@ -182372,7 +283525,7 @@ synonym: "curvature of vertebral column" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004488 ! vertebral column shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column [Term] id: OBA:VT0004183 @@ -182382,8 +283535,8 @@ synonym: "functionality of sympathetic nervous system" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000013 ! sympathetic nervous system -relationship: inheres_in UBERON:0000013 ! sympathetic nervous system +intersection_of: RO:0000052 UBERON:0000013 ! inheres in sympathetic nervous system +relationship: RO:0000052 UBERON:0000013 ! inheres in sympathetic nervous system [Term] id: OBA:VT0004184 @@ -182393,8 +283546,8 @@ synonym: "functionality of baroreceptor" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0004019 ! baroreceptor -relationship: inheres_in UBERON:0004019 ! baroreceptor +intersection_of: RO:0000052 UBERON:0004019 ! inheres in baroreceptor +relationship: RO:0000052 UBERON:0004019 ! inheres in baroreceptor [Term] id: OBA:VT0004186 @@ -182403,8 +283556,8 @@ def: "The morphology of a area postrema." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of area postrema" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005868 ! sensory circumventricular organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002162 ! area postrema -relationship: inheres_in UBERON:0002162 ! area postrema +intersection_of: RO:0000052 UBERON:0002162 ! inheres in area postrema +relationship: RO:0000052 UBERON:0002162 ! inheres in area postrema [Term] id: OBA:VT0004189 @@ -182414,8 +283567,8 @@ synonym: "morphology of alveolar ridge" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004103 ! alveolar ridge -relationship: inheres_in UBERON:0004103 ! alveolar ridge +intersection_of: RO:0000052 UBERON:0004103 ! inheres in alveolar ridge +relationship: RO:0000052 UBERON:0004103 ! inheres in alveolar ridge [Term] id: OBA:VT0004192 @@ -182425,7 +283578,7 @@ synonym: "morphology of kidney pyramid" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000332 ! kidney pyramid quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004200 ! kidney pyramid +intersection_of: RO:0000052 UBERON:0004200 ! inheres in kidney pyramid [Term] id: OBA:VT0004193 @@ -182435,8 +283588,8 @@ synonym: "morphology of renal papilla" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001228 ! renal papilla -relationship: inheres_in UBERON:0001228 ! renal papilla +intersection_of: RO:0000052 UBERON:0001228 ! inheres in renal papilla +relationship: RO:0000052 UBERON:0001228 ! inheres in renal papilla [Term] id: OBA:VT0004194 @@ -182446,7 +283599,7 @@ synonym: "morphology of renal pelvis" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000327 ! renal pelvis quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001224 ! renal pelvis +intersection_of: RO:0000052 UBERON:0001224 ! inheres in renal pelvis [Term] id: OBA:VT0004195 @@ -182456,8 +283609,8 @@ synonym: "morphology of kidney calyx" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006517 ! kidney calyx -relationship: inheres_in UBERON:0006517 ! kidney calyx +intersection_of: RO:0000052 UBERON:0006517 ! inheres in kidney calyx +relationship: RO:0000052 UBERON:0006517 ! inheres in kidney calyx [Term] id: OBA:VT0004203 @@ -182467,8 +283620,8 @@ synonym: "morphology of cephalic midbrain flexure" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005818 ! cephalic midbrain flexure -relationship: inheres_in UBERON:0005818 ! cephalic midbrain flexure +intersection_of: RO:0000052 UBERON:0005818 ! inheres in cephalic midbrain flexure +relationship: RO:0000052 UBERON:0005818 ! inheres in cephalic midbrain flexure [Term] id: OBA:VT0004204 @@ -182478,7 +283631,7 @@ synonym: "size of stapes bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003739 ! auditory ossicle size trait is_a: OBA:VT0005107 ! stapes morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001687 ! stapes bone +intersection_of: RO:0000052 UBERON:0001687 ! inheres in stapes bone [Term] id: OBA:VT0004209 @@ -182487,8 +283640,8 @@ def: "The quality of a sensory perception of sweet taste." [AUTO:patterns/patter synonym: "quality of sensory perception of sweet taste" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050916 ! sensory perception of sweet taste -relationship: inheres_in GO:0050916 ! sensory perception of sweet taste +intersection_of: RO:0000052 GO:0050916 ! inheres in sensory perception of sweet taste +relationship: RO:0000052 GO:0050916 ! inheres in sensory perception of sweet taste [Term] id: OBA:VT0004210 @@ -182497,8 +283650,8 @@ def: "The quality of a sensory perception of bitter taste." [AUTO:patterns/patte synonym: "quality of sensory perception of bitter taste" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050913 ! sensory perception of bitter taste -relationship: inheres_in GO:0050913 ! sensory perception of bitter taste +intersection_of: RO:0000052 GO:0050913 ! inheres in sensory perception of bitter taste +relationship: RO:0000052 GO:0050913 ! inheres in sensory perception of bitter taste [Term] id: OBA:VT0004211 @@ -182507,8 +283660,8 @@ def: "The quality of a sensory perception of sour taste." [AUTO:patterns/pattern synonym: "quality of sensory perception of sour taste" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050915 ! sensory perception of sour taste -relationship: inheres_in GO:0050915 ! sensory perception of sour taste +intersection_of: RO:0000052 GO:0050915 ! inheres in sensory perception of sour taste +relationship: RO:0000052 GO:0050915 ! inheres in sensory perception of sour taste [Term] id: OBA:VT0004212 @@ -182517,8 +283670,8 @@ def: "The quality of a sensory perception of salty taste." [AUTO:patterns/patter synonym: "quality of sensory perception of salty taste" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050914 ! sensory perception of salty taste -relationship: inheres_in GO:0050914 ! sensory perception of salty taste +intersection_of: RO:0000052 GO:0050914 ! inheres in sensory perception of salty taste +relationship: RO:0000052 GO:0050914 ! inheres in sensory perception of salty taste [Term] id: OBA:VT0004213 @@ -182527,8 +283680,8 @@ def: "The quality of a sensory perception of umami taste." [AUTO:patterns/patter synonym: "quality of sensory perception of umami taste" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050917 ! sensory perception of umami taste -relationship: inheres_in GO:0050917 ! sensory perception of umami taste +intersection_of: RO:0000052 GO:0050917 ! inheres in sensory perception of umami taste +relationship: RO:0000052 GO:0050917 ! inheres in sensory perception of umami taste [Term] id: OBA:VT0004214 @@ -182538,7 +283691,7 @@ synonym: "morphology of diaphysis" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000552 ! diaphysis quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004769 ! diaphysis +intersection_of: RO:0000052 UBERON:0004769 ! inheres in diaphysis [Term] id: OBA:VT0004221 @@ -182548,8 +283701,8 @@ synonym: "morphology of iridocorneal angle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006206 ! iridocorneal angle -relationship: inheres_in UBERON:0006206 ! iridocorneal angle +intersection_of: RO:0000052 UBERON:0006206 ! inheres in iridocorneal angle +relationship: RO:0000052 UBERON:0006206 ! inheres in iridocorneal angle [Term] id: OBA:VT0004223 @@ -182559,7 +283712,7 @@ synonym: "size of eye trabecular meshwork" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005203 ! trabecular meshwork morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005969 ! eye trabecular meshwork +intersection_of: RO:0000052 UBERON:0005969 ! inheres in eye trabecular meshwork [Term] id: OBA:VT0004226 @@ -182569,7 +283722,7 @@ synonym: "size of canal of Schlemm" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0005204 ! canal of Schlemm morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0004029 ! canal of Schlemm +intersection_of: RO:0000052 UBERON:0004029 ! inheres in canal of Schlemm [Term] id: OBA:VT0004230 @@ -182578,8 +283731,8 @@ def: "The morphology of a primitive red blood cell." [AUTO:patterns/patterns/ent synonym: "morphology of primitive red blood cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005897 ! erythroid lineage cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002355 ! primitive red blood cell -relationship: inheres_in CL:0002355 ! primitive red blood cell +intersection_of: RO:0000052 CL:0002355 ! inheres in primitive red blood cell +relationship: RO:0000052 CL:0002355 ! inheres in primitive red blood cell [Term] id: OBA:VT0004234 @@ -182589,7 +283742,7 @@ synonym: "morphology of masticatory muscle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003692 ! muscle organ morphology is_a: OBA:1000322 ! masticatory muscle quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003681 ! masticatory muscle +intersection_of: RO:0000052 UBERON:0003681 ! inheres in masticatory muscle [Term] id: OBA:VT0004235 @@ -182599,7 +283752,7 @@ synonym: "morphology of masseter muscle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000430 ! masseter muscle quality is_a: OBA:VT0004234 ! masticatory muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001597 ! masseter muscle +intersection_of: RO:0000052 UBERON:0001597 ! inheres in masseter muscle [Term] id: OBA:VT0004236 @@ -182609,7 +283762,7 @@ synonym: "size of masseter muscle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0004235 ! masseter muscle morphology trait is_a: OBA:VT0010113 ! masticatory muscle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001597 ! masseter muscle +intersection_of: RO:0000052 UBERON:0001597 ! inheres in masseter muscle [Term] id: OBA:VT0004237 @@ -182618,8 +283771,8 @@ def: "The morphology of a pterygoid muscle." [AUTO:patterns/patterns/entity_attr synonym: "morphology of pterygoid muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004234 ! masticatory muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006720 ! pterygoid muscle -relationship: inheres_in UBERON:0006720 ! pterygoid muscle +intersection_of: RO:0000052 UBERON:0006720 ! inheres in pterygoid muscle +relationship: RO:0000052 UBERON:0006720 ! inheres in pterygoid muscle [Term] id: OBA:VT0004238 @@ -182629,7 +283782,7 @@ synonym: "size of pterygoid muscle" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0004237 ! pterygoid muscle morphology trait is_a: OBA:VT0010113 ! masticatory muscle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006720 ! pterygoid muscle +intersection_of: RO:0000052 UBERON:0006720 ! inheres in pterygoid muscle [Term] id: OBA:VT0004239 @@ -182639,7 +283792,7 @@ synonym: "morphology of temporalis muscle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000504 ! temporalis muscle quality is_a: OBA:VT0004234 ! masticatory muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001598 ! temporalis muscle +intersection_of: RO:0000052 UBERON:0001598 ! inheres in temporalis muscle [Term] id: OBA:VT0004240 @@ -182649,7 +283802,7 @@ synonym: "size of temporalis muscle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0004239 ! temporalis muscle morphology trait is_a: OBA:VT0010113 ! masticatory muscle size trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001598 ! temporalis muscle +intersection_of: RO:0000052 UBERON:0001598 ! inheres in temporalis muscle [Term] id: OBA:VT0004242 @@ -182658,8 +283811,8 @@ def: "The morphology of a plasmacytoid dendritic cell." [AUTO:patterns/patterns/ synonym: "morphology of plasmacytoid dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005461 ! dendritic cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000784 ! plasmacytoid dendritic cell -relationship: inheres_in CL:0000784 ! plasmacytoid dendritic cell +intersection_of: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell +relationship: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell [Term] id: OBA:VT0004246 @@ -182668,8 +283821,8 @@ def: "The morphology of a extensor digitorum longus." [AUTO:patterns/patterns/en synonym: "morphology of extensor digitorum longus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001386 ! extensor digitorum longus -relationship: inheres_in UBERON:0001386 ! extensor digitorum longus +intersection_of: RO:0000052 UBERON:0001386 ! inheres in extensor digitorum longus +relationship: RO:0000052 UBERON:0001386 ! inheres in extensor digitorum longus [Term] id: OBA:VT0004248 @@ -182678,8 +283831,8 @@ def: "The morphology of a epaxial myotome region." [AUTO:patterns/patterns/entit synonym: "morphology of epaxial myotome region" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000759 ! skeletal muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003900 ! epaxial myotome region -relationship: inheres_in UBERON:0003900 ! epaxial myotome region +intersection_of: RO:0000052 UBERON:0003900 ! inheres in epaxial myotome region +relationship: RO:0000052 UBERON:0003900 ! inheres in epaxial myotome region [Term] id: OBA:VT0004249 @@ -182689,8 +283842,8 @@ synonym: "morphology of crista ampullaris" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004721 ! crista ampullaris -relationship: inheres_in UBERON:0004721 ! crista ampullaris +intersection_of: RO:0000052 UBERON:0004721 ! inheres in crista ampullaris +relationship: RO:0000052 UBERON:0004721 ! inheres in crista ampullaris [Term] id: OBA:VT0004252 @@ -182700,8 +283853,8 @@ synonym: "direction of heart looping" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100002 ! biological process attribute is_a: PATO:0000039 ! direction intersection_of: PATO:0000039 ! direction -intersection_of: inheres_in GO:0001947 ! heart looping -relationship: inheres_in GO:0001947 ! heart looping +intersection_of: RO:0000052 GO:0001947 ! inheres in heart looping +relationship: RO:0000052 GO:0001947 ! inheres in heart looping [Term] id: OBA:VT0004256 @@ -182710,8 +283863,8 @@ def: "The morphology of a decidua." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of decidua" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002086 ! extraembryonic tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002450 ! decidua -relationship: inheres_in UBERON:0002450 ! decidua +intersection_of: RO:0000052 UBERON:0002450 ! inheres in decidua +relationship: RO:0000052 UBERON:0002450 ! inheres in decidua [Term] id: OBA:VT0004257 @@ -182721,7 +283874,7 @@ synonym: "mass of placenta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000620 ! placenta quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:VT0004258 @@ -182731,7 +283884,7 @@ synonym: "size of placenta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001711 ! placenta morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:VT0004261 @@ -182740,8 +283893,8 @@ def: "The morphology of a germinal neuroepithelium." [AUTO:patterns/patterns/ent synonym: "morphology of germinal neuroepithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004022 ! germinal neuroepithelium -relationship: inheres_in UBERON:0004022 ! germinal neuroepithelium +intersection_of: RO:0000052 UBERON:0004022 ! inheres in germinal neuroepithelium +relationship: RO:0000052 UBERON:0004022 ! inheres in germinal neuroepithelium [Term] id: OBA:VT0004264 @@ -182751,8 +283904,8 @@ synonym: "functionality of extraembryonic structure" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000478 ! extraembryonic structure -relationship: inheres_in UBERON:0000478 ! extraembryonic structure +intersection_of: RO:0000052 UBERON:0000478 ! inheres in extraembryonic structure +relationship: RO:0000052 UBERON:0000478 ! inheres in extraembryonic structure [Term] id: OBA:VT0004266 @@ -182762,7 +283915,7 @@ synonym: "color of placenta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001711 ! placenta morphology trait is_a: PATO:0000014 ! color intersection_of: PATO:0000014 ! color -intersection_of: inheres_in UBERON:0001987 ! placenta +intersection_of: RO:0000052 UBERON:0001987 ! inheres in placenta [Term] id: OBA:VT0004267 @@ -182771,8 +283924,8 @@ def: "The morphology of a optic tract." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of optic tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001908 ! optic tract -relationship: inheres_in UBERON:0001908 ! optic tract +intersection_of: RO:0000052 UBERON:0001908 ! inheres in optic tract +relationship: RO:0000052 UBERON:0001908 ! inheres in optic tract [Term] id: OBA:VT0004268 @@ -182782,8 +283935,8 @@ synonym: "morphology of optic stalk" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003098 ! optic stalk -relationship: inheres_in UBERON:0003098 ! optic stalk +intersection_of: RO:0000052 UBERON:0003098 ! inheres in optic stalk +relationship: RO:0000052 UBERON:0003098 ! inheres in optic stalk [Term] id: OBA:VT0004269 @@ -182793,8 +283946,8 @@ synonym: "morphology of optic cup" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003072 ! optic cup -relationship: inheres_in UBERON:0003072 ! optic cup +intersection_of: RO:0000052 UBERON:0003072 ! inheres in optic cup +relationship: RO:0000052 UBERON:0003072 ! inheres in optic cup [Term] id: OBA:VT0004271 @@ -182808,8 +283961,8 @@ def: "The morphology of a basement membrane." [AUTO:patterns/patterns/entity_att synonym: "morphology of basement membrane" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005791 ! extracellular matrix morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0005604 ! basement membrane -relationship: inheres_in GO:0005604 ! basement membrane +intersection_of: RO:0000052 GO:0005604 ! inheres in basement membrane +relationship: RO:0000052 GO:0005604 ! inheres in basement membrane [Term] id: OBA:VT0004273 @@ -182819,8 +283972,8 @@ synonym: "morphology of basal lamina of epithelium" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000482 ! basal lamina of epithelium -relationship: inheres_in UBERON:0000482 ! basal lamina of epithelium +intersection_of: RO:0000052 UBERON:0000482 ! inheres in basal lamina of epithelium +relationship: RO:0000052 UBERON:0000482 ! inheres in basal lamina of epithelium [Term] id: OBA:VT0004274 @@ -182830,8 +283983,8 @@ synonym: "morphology of ganglionic eminence" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004023 ! ganglionic eminence -relationship: inheres_in UBERON:0004023 ! ganglionic eminence +intersection_of: RO:0000052 UBERON:0004023 ! inheres in ganglionic eminence +relationship: RO:0000052 UBERON:0004023 ! inheres in ganglionic eminence [Term] id: OBA:VT0004275 @@ -182841,8 +283994,8 @@ synonym: "morphology of postnatal subventricular zone" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004922 ! postnatal subventricular zone -relationship: inheres_in UBERON:0004922 ! postnatal subventricular zone +intersection_of: RO:0000052 UBERON:0004922 ! inheres in postnatal subventricular zone +relationship: RO:0000052 UBERON:0004922 ! inheres in postnatal subventricular zone [Term] id: OBA:VT0004276 @@ -182852,8 +284005,8 @@ synonym: "morphology of medial ganglionic eminence" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004024 ! medial ganglionic eminence -relationship: inheres_in UBERON:0004024 ! medial ganglionic eminence +intersection_of: RO:0000052 UBERON:0004024 ! inheres in medial ganglionic eminence +relationship: RO:0000052 UBERON:0004024 ! inheres in medial ganglionic eminence [Term] id: OBA:VT0004277 @@ -182863,8 +284016,8 @@ synonym: "morphology of lateral ganglionic eminence" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004025 ! lateral ganglionic eminence -relationship: inheres_in UBERON:0004025 ! lateral ganglionic eminence +intersection_of: RO:0000052 UBERON:0004025 ! inheres in lateral ganglionic eminence +relationship: RO:0000052 UBERON:0004025 ! inheres in lateral ganglionic eminence [Term] id: OBA:VT0004278 @@ -182874,8 +284027,8 @@ synonym: "morphology of caudal ganglionic eminence" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004026 ! caudal ganglionic eminence -relationship: inheres_in UBERON:0004026 ! caudal ganglionic eminence +intersection_of: RO:0000052 UBERON:0004026 ! inheres in caudal ganglionic eminence +relationship: RO:0000052 UBERON:0004026 ! inheres in caudal ganglionic eminence [Term] id: OBA:VT0004280 @@ -182885,8 +284038,8 @@ synonym: "morphology of oculomotor nuclear complex" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001715 ! oculomotor nuclear complex -relationship: inheres_in UBERON:0001715 ! oculomotor nuclear complex +intersection_of: RO:0000052 UBERON:0001715 ! inheres in oculomotor nuclear complex +relationship: RO:0000052 UBERON:0001715 ! inheres in oculomotor nuclear complex [Term] id: OBA:VT0004281 @@ -182896,8 +284049,8 @@ synonym: "morphology of hypoglossal nucleus" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002871 ! hypoglossal nucleus -relationship: inheres_in UBERON:0002871 ! hypoglossal nucleus +intersection_of: RO:0000052 UBERON:0002871 ! inheres in hypoglossal nucleus +relationship: RO:0000052 UBERON:0002871 ! inheres in hypoglossal nucleus [Term] id: OBA:VT0004284 @@ -182907,7 +284060,7 @@ synonym: "morphology of Descemet's membrane" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000439 ! Descemet's membrane quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004367 ! Descemet's membrane +intersection_of: RO:0000052 UBERON:0004367 ! inheres in Descemet's membrane [Term] id: OBA:VT0004286 @@ -182917,7 +284070,7 @@ synonym: "morphology of internal acoustic meatus" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000453 ! internal acoustic meatus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011859 ! internal acoustic meatus +intersection_of: RO:0000052 UBERON:0011859 ! inheres in internal acoustic meatus [Term] id: OBA:VT0004287 @@ -182927,8 +284080,8 @@ synonym: "morphology of lamina of spiral limbus" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002276 ! lamina of spiral limbus -relationship: inheres_in UBERON:0002276 ! lamina of spiral limbus +intersection_of: RO:0000052 UBERON:0002276 ! inheres in lamina of spiral limbus +relationship: RO:0000052 UBERON:0002276 ! inheres in lamina of spiral limbus [Term] id: OBA:VT0004288 @@ -182937,8 +284090,8 @@ def: "The morphology of a spiral ligament." [AUTO:patterns/patterns/entity_attri synonym: "morphology of spiral ligament" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006725 ! spiral ligament -relationship: inheres_in UBERON:0006725 ! spiral ligament +intersection_of: RO:0000052 UBERON:0006725 ! inheres in spiral ligament +relationship: RO:0000052 UBERON:0006725 ! inheres in spiral ligament [Term] id: OBA:VT0004289 @@ -182948,7 +284101,7 @@ synonym: "morphology of bony labyrinth" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000677 ! bony labyrinth quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001839 ! bony labyrinth +intersection_of: RO:0000052 UBERON:0001839 ! inheres in bony labyrinth [Term] id: OBA:VT0004290 @@ -182958,8 +284111,8 @@ synonym: "morphology of stapes base" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002496 ! stapes base -relationship: inheres_in UBERON:0002496 ! stapes base +intersection_of: RO:0000052 UBERON:0002496 ! inheres in stapes base +relationship: RO:0000052 UBERON:0002496 ! inheres in stapes base [Term] id: OBA:VT0004293 @@ -182968,8 +284121,8 @@ def: "The morphology of a type 1 otic fibrocyte." [AUTO:patterns/patterns/entity synonym: "morphology of type 1 otic fibrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002670 ! type 1 otic fibrocyte -relationship: inheres_in CL:0002670 ! type 1 otic fibrocyte +intersection_of: RO:0000052 CL:0002670 ! inheres in type 1 otic fibrocyte +relationship: RO:0000052 CL:0002670 ! inheres in type 1 otic fibrocyte [Term] id: OBA:VT0004294 @@ -182978,8 +284131,8 @@ def: "The morphology of a type 2 otic fibrocyte." [AUTO:patterns/patterns/entity synonym: "morphology of type 2 otic fibrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002666 ! type 2 otic fibrocyte -relationship: inheres_in CL:0002666 ! type 2 otic fibrocyte +intersection_of: RO:0000052 CL:0002666 ! inheres in type 2 otic fibrocyte +relationship: RO:0000052 CL:0002666 ! inheres in type 2 otic fibrocyte [Term] id: OBA:VT0004295 @@ -182988,8 +284141,8 @@ def: "The morphology of a type 3 otic fibrocyte." [AUTO:patterns/patterns/entity synonym: "morphology of type 3 otic fibrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002669 ! type 3 otic fibrocyte -relationship: inheres_in CL:0002669 ! type 3 otic fibrocyte +intersection_of: RO:0000052 CL:0002669 ! inheres in type 3 otic fibrocyte +relationship: RO:0000052 CL:0002669 ! inheres in type 3 otic fibrocyte [Term] id: OBA:VT0004296 @@ -182998,8 +284151,8 @@ def: "The morphology of a type 4 otic fibrocyte." [AUTO:patterns/patterns/entity synonym: "morphology of type 4 otic fibrocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002668 ! type 4 otic fibrocyte -relationship: inheres_in CL:0002668 ! type 4 otic fibrocyte +intersection_of: RO:0000052 CL:0002668 ! inheres in type 4 otic fibrocyte +relationship: RO:0000052 CL:0002668 ! inheres in type 4 otic fibrocyte [Term] id: OBA:VT0004297 @@ -183008,8 +284161,8 @@ def: "The morphology of a sensory neuron of dorsal root ganglion." [AUTO:pattern synonym: "morphology of sensory neuron of dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000965 ! sensory neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001451 ! sensory neuron of dorsal root ganglion -relationship: inheres_in CL:1001451 ! sensory neuron of dorsal root ganglion +intersection_of: RO:0000052 CL:1001451 ! inheres in sensory neuron of dorsal root ganglion +relationship: RO:0000052 CL:1001451 ! inheres in sensory neuron of dorsal root ganglion [Term] id: OBA:VT0004300 @@ -183018,8 +284171,8 @@ def: "The morphology of a organ of Corti supporting cell." [AUTO:patterns/patter synonym: "morphology of organ of Corti supporting cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002490 ! organ of Corti supporting cell -relationship: inheres_in CL:0002490 ! organ of Corti supporting cell +intersection_of: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell +relationship: RO:0000052 CL:0002490 ! inheres in organ of Corti supporting cell [Term] id: OBA:VT0004302 @@ -183028,8 +284181,8 @@ def: "The morphology of a Deiter's cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of Deiter's cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004300 ! organ of Corti supporting cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000635 ! Deiter's cell -relationship: inheres_in CL:0000635 ! Deiter's cell +intersection_of: RO:0000052 CL:0000635 ! inheres in Deiter's cell +relationship: RO:0000052 CL:0000635 ! inheres in Deiter's cell [Term] id: OBA:VT0004303 @@ -183038,8 +284191,8 @@ def: "The morphology of a Hensen cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of Hensen cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004300 ! organ of Corti supporting cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000633 ! Hensen cell -relationship: inheres_in CL:0000633 ! Hensen cell +intersection_of: RO:0000052 CL:0000633 ! inheres in Hensen cell +relationship: RO:0000052 CL:0000633 ! inheres in Hensen cell [Term] id: OBA:VT0004305 @@ -183049,8 +284202,8 @@ synonym: "morphology of cochlear canal" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006106 ! cochlear canal -relationship: inheres_in UBERON:0006106 ! cochlear canal +intersection_of: RO:0000052 UBERON:0006106 ! inheres in cochlear canal +relationship: RO:0000052 UBERON:0006106 ! inheres in cochlear canal [Term] id: OBA:VT0004306 @@ -183060,7 +284213,7 @@ synonym: "size of cochlear canal" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0004305 ! Rosenthal canal morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006106 ! cochlear canal +intersection_of: RO:0000052 UBERON:0006106 ! inheres in cochlear canal [Term] id: OBA:VT0004308 @@ -183070,7 +284223,7 @@ synonym: "morphology of basilar membrane of cochlea" EXACT [AUTO:patterns/patter is_a: OBA:1000754 ! basilar membrane of cochlea quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002226 ! basilar membrane of cochlea +intersection_of: RO:0000052 UBERON:0002226 ! inheres in basilar membrane of cochlea [Term] id: OBA:VT0004310 @@ -183080,7 +284233,7 @@ synonym: "size of ear vesicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000172 ! tube size is_a: OBA:VT0006030 ! otic vesicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003051 ! ear vesicle +intersection_of: RO:0000052 UBERON:0003051 ! inheres in ear vesicle [Term] id: OBA:VT0004313 @@ -183090,7 +284243,7 @@ synonym: "size of vestibulocochlear ganglion" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0002855 ! cochlear ganglion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002827 ! vestibulocochlear ganglion +intersection_of: RO:0000052 UBERON:0002827 ! inheres in vestibulocochlear ganglion [Term] id: OBA:VT0004316 @@ -183100,7 +284253,7 @@ synonym: "size of saccule of membranous labyrinth" EXACT [AUTO:patterns/patterns is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006089 ! saccule morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001854 ! saccule of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001854 ! inheres in saccule of membranous labyrinth [Term] id: OBA:VT0004320 @@ -183110,7 +284263,7 @@ synonym: "shape of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000157 ! sternum morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:VT0004321 @@ -183120,7 +284273,7 @@ synonym: "length of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004323 ! sternum size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:VT0004322 @@ -183129,8 +284282,8 @@ def: "The morphology of a sternebra." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of sternebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002208 ! sternebra -relationship: inheres_in UBERON:0002208 ! sternebra +intersection_of: RO:0000052 UBERON:0002208 ! inheres in sternebra +relationship: RO:0000052 UBERON:0002208 ! inheres in sternebra [Term] id: OBA:VT0004323 @@ -183140,7 +284293,7 @@ synonym: "size of sternum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000157 ! sternum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000975 ! sternum +intersection_of: RO:0000052 UBERON:0000975 ! inheres in sternum [Term] id: OBA:VT0004326 @@ -183149,8 +284302,8 @@ def: "The has number of of a vestibular hair cell." [AUTO:patterns/patterns/enti synonym: "has number of of vestibular hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006006 ! sensory neuron quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000609 ! vestibular hair cell -relationship: inheres_in CL:0000609 ! vestibular hair cell +intersection_of: RO:0000052 CL:0000609 ! inheres in vestibular hair cell +relationship: RO:0000052 CL:0000609 ! inheres in vestibular hair cell [Term] id: OBA:VT0004330 @@ -183160,8 +284313,8 @@ synonym: "morphology of macula of saccule of membranous labyrinth" EXACT [AUTO:p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002212 ! macula of saccule of membranous labyrinth -relationship: inheres_in UBERON:0002212 ! macula of saccule of membranous labyrinth +intersection_of: RO:0000052 UBERON:0002212 ! inheres in macula of saccule of membranous labyrinth +relationship: RO:0000052 UBERON:0002212 ! inheres in macula of saccule of membranous labyrinth [Term] id: OBA:VT0004333 @@ -183171,8 +284324,8 @@ synonym: "morphology of macula of utricle of membranous labyrinth" EXACT [AUTO:p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002214 ! macula of utricle of membranous labyrinth -relationship: inheres_in UBERON:0002214 ! macula of utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0002214 ! inheres in macula of utricle of membranous labyrinth +relationship: RO:0000052 UBERON:0002214 ! inheres in macula of utricle of membranous labyrinth [Term] id: OBA:VT0004335 @@ -183182,7 +284335,7 @@ synonym: "size of utricle of membranous labyrinth" EXACT [AUTO:patterns/patterns is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006090 ! utricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001853 ! utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth [Term] id: OBA:VT0004338 @@ -183192,7 +284345,7 @@ synonym: "size of clavicle bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0005298 ! clavicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001105 ! clavicle bone +intersection_of: RO:0000052 UBERON:0001105 ! inheres in clavicle bone [Term] id: OBA:VT0004340 @@ -183202,7 +284355,7 @@ synonym: "length of scapula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004343 ! scapula size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0006849 ! scapula +intersection_of: RO:0000052 UBERON:0006849 ! inheres in scapula [Term] id: OBA:VT0004343 @@ -183212,7 +284365,7 @@ synonym: "size of scapula" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000149 ! scapula morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0006849 ! scapula +intersection_of: RO:0000052 UBERON:0006849 ! inheres in scapula [Term] id: OBA:VT0004345 @@ -183222,8 +284375,8 @@ synonym: "morphology of acromion" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002497 ! acromion -relationship: inheres_in UBERON:0002497 ! acromion +intersection_of: RO:0000052 UBERON:0002497 ! inheres in acromion +relationship: RO:0000052 UBERON:0002497 ! inheres in acromion [Term] id: OBA:VT0004347 @@ -183233,8 +284386,8 @@ synonym: "morphology of scapula spine" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004651 ! scapula spine -relationship: inheres_in UBERON:0004651 ! scapula spine +intersection_of: RO:0000052 UBERON:0004651 ! inheres in scapula spine +relationship: RO:0000052 UBERON:0004651 ! inheres in scapula spine [Term] id: OBA:VT0004348 @@ -183244,7 +284397,7 @@ synonym: "length of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002381 ! long bone length is_a: OBA:VT1000369 ! femur size trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0004350 @@ -183254,7 +284407,7 @@ synonym: "length of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002381 ! long bone length is_a: OBA:VT0100000 ! humerus size trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0004353 @@ -183264,7 +284417,7 @@ synonym: "morphology of deltopectoral crest" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000272 ! deltopectoral crest quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002498 ! deltopectoral crest +intersection_of: RO:0000052 UBERON:0002498 ! inheres in deltopectoral crest [Term] id: OBA:VT0004355 @@ -183275,7 +284428,7 @@ is_a: OBA:0002374 ! radius bone size is_a: OBA:0002381 ! long bone length is_a: OBA:0003005 ! forelimb zeugopod bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:VT0004357 @@ -183285,7 +284438,7 @@ synonym: "length of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002381 ! long bone length is_a: OBA:VT0100001 ! tibia size trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT0004358 @@ -183296,7 +284449,7 @@ is_a: OBA:0002732 ! long bone curvature is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0000558 ! tibia morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT0004361 @@ -183307,7 +284460,7 @@ is_a: OBA:0002477 ! forelimb zeugopod bone curvature is_a: OBA:0002489 ! ulna shape is_a: OBA:0002732 ! long bone curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:VT0004364 @@ -183317,7 +284470,7 @@ synonym: "size of stria vascularis of cochlear duct" EXACT [AUTO:patterns/patter is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000048 ! stria vascularis morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002282 ! stria vascularis of cochlear duct +intersection_of: RO:0000052 UBERON:0002282 ! inheres in stria vascularis of cochlear duct [Term] id: OBA:VT0004365 @@ -183326,8 +284479,8 @@ def: "The morphology of a strial basal cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of strial basal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002493 ! strial basal cell -relationship: inheres_in CL:0002493 ! strial basal cell +intersection_of: RO:0000052 CL:0002493 ! inheres in strial basal cell +relationship: RO:0000052 CL:0002493 ! inheres in strial basal cell [Term] id: OBA:VT0004366 @@ -183336,8 +284489,8 @@ def: "The morphology of a strial marginal cell." [AUTO:patterns/patterns/entity_ synonym: "morphology of strial marginal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002492 ! strial marginal cell -relationship: inheres_in CL:0002492 ! strial marginal cell +intersection_of: RO:0000052 CL:0002492 ! inheres in strial marginal cell +relationship: RO:0000052 CL:0002492 ! inheres in strial marginal cell [Term] id: OBA:VT0004367 @@ -183346,8 +284499,8 @@ def: "The morphology of a strial intermediate cell." [AUTO:patterns/patterns/ent synonym: "morphology of strial intermediate cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003749 ! melanocyte morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002486 ! strial intermediate cell -relationship: inheres_in CL:0002486 ! strial intermediate cell +intersection_of: RO:0000052 CL:0002486 ! inheres in strial intermediate cell +relationship: RO:0000052 CL:0002486 ! inheres in strial intermediate cell [Term] id: OBA:VT0004368 @@ -183366,7 +284519,7 @@ is_a: OBA:0002379 ! ulna size is_a: OBA:0002381 ! long bone length is_a: OBA:0003005 ! forelimb zeugopod bone length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:VT0004371 @@ -183377,7 +284530,7 @@ is_a: OBA:0002732 ! long bone curvature is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0000559 ! femur morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0004372 @@ -183388,7 +284541,7 @@ is_a: OBA:0002732 ! long bone curvature is_a: OBA:0005469 ! limb long bone shape is_a: OBA:VT0002187 ! fibula morphology trait intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001446 ! fibula +intersection_of: RO:0000052 UBERON:0001446 ! inheres in fibula [Term] id: OBA:VT0004373 @@ -183398,7 +284551,7 @@ synonym: "curvature of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002459 ! humerus shape is_a: OBA:0002732 ! long bone curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0004374 @@ -183409,7 +284562,7 @@ is_a: OBA:0002477 ! forelimb zeugopod bone curvature is_a: OBA:0002732 ! long bone curvature is_a: OBA:0003351 ! radius bone shape intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0001423 ! radius bone +intersection_of: RO:0000052 UBERON:0001423 ! inheres in radius bone [Term] id: OBA:VT0004387 @@ -183419,8 +284572,8 @@ synonym: "morphology of prechordal plate" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003063 ! prechordal plate -relationship: inheres_in UBERON:0003063 ! prechordal plate +intersection_of: RO:0000052 UBERON:0003063 ! inheres in prechordal plate +relationship: RO:0000052 UBERON:0003063 ! inheres in prechordal plate [Term] id: OBA:VT0004389 @@ -183429,8 +284582,8 @@ def: "The morphology of a respiratory bronchiole." [AUTO:patterns/patterns/entit synonym: "morphology of respiratory bronchiole" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002267 ! bronchiole morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002188 ! respiratory bronchiole -relationship: inheres_in UBERON:0002188 ! respiratory bronchiole +intersection_of: RO:0000052 UBERON:0002188 ! inheres in respiratory bronchiole +relationship: RO:0000052 UBERON:0002188 ! inheres in respiratory bronchiole [Term] id: OBA:VT0004390 @@ -183440,8 +284593,8 @@ synonym: "morphology of bronchoalveolar duct junction" EXACT [AUTO:patterns/patt is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004903 ! bronchoalveolar duct junction -relationship: inheres_in UBERON:0004903 ! bronchoalveolar duct junction +intersection_of: RO:0000052 UBERON:0004903 ! inheres in bronchoalveolar duct junction +relationship: RO:0000052 UBERON:0004903 ! inheres in bronchoalveolar duct junction [Term] id: OBA:VT0004391 @@ -183451,8 +284604,8 @@ synonym: "morphology of respiratory tube" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000117 ! respiratory tube -relationship: inheres_in UBERON:0000117 ! respiratory tube +intersection_of: RO:0000052 UBERON:0000117 ! inheres in respiratory tube +relationship: RO:0000052 UBERON:0000117 ! inheres in respiratory tube [Term] id: OBA:VT0004393 @@ -183461,8 +284614,8 @@ def: "The morphology of a cochlear inner hair cell." [AUTO:patterns/patterns/ent synonym: "morphology of cochlear inner hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002622 ! cochlear hair cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000589 ! cochlear inner hair cell -relationship: inheres_in CL:0000589 ! cochlear inner hair cell +intersection_of: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell +relationship: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell [Term] id: OBA:VT0004394 @@ -183471,8 +284624,8 @@ def: "The has number of of a cochlear inner hair cell." [AUTO:patterns/patterns/ synonym: "has number of of cochlear inner hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004406 ! cochlear hair cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000589 ! cochlear inner hair cell -relationship: inheres_in CL:0000589 ! cochlear inner hair cell +intersection_of: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell +relationship: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell [Term] id: OBA:VT0004399 @@ -183481,8 +284634,8 @@ def: "The morphology of a cochlear outer hair cell." [AUTO:patterns/patterns/ent synonym: "morphology of cochlear outer hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002622 ! cochlear hair cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell -relationship: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell +relationship: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:VT0004400 @@ -183491,8 +284644,8 @@ def: "The has number of of a cochlear outer hair cell." [AUTO:patterns/patterns/ synonym: "has number of of cochlear outer hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004406 ! cochlear hair cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell -relationship: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell +relationship: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:VT0004406 @@ -183501,8 +284654,8 @@ def: "The has number of of a auditory hair cell." [AUTO:patterns/patterns/entity synonym: "has number of of auditory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006006 ! sensory neuron quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000202 ! auditory hair cell -relationship: inheres_in CL:0000202 ! auditory hair cell +intersection_of: RO:0000052 CL:0000202 ! inheres in auditory hair cell +relationship: RO:0000052 CL:0000202 ! inheres in auditory hair cell [Term] id: OBA:VT0004409 @@ -183511,8 +284664,8 @@ def: "The morphology of a crista ampullaris neuroepithelium." [AUTO:patterns/pat synonym: "morphology of crista ampullaris neuroepithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003432 ! inner ear epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006935 ! crista ampullaris neuroepithelium -relationship: inheres_in UBERON:0006935 ! crista ampullaris neuroepithelium +intersection_of: RO:0000052 UBERON:0006935 ! inheres in crista ampullaris neuroepithelium +relationship: RO:0000052 UBERON:0006935 ! inheres in crista ampullaris neuroepithelium [Term] id: OBA:VT0004423 @@ -183522,8 +284675,8 @@ synonym: "morphology of squamous part of temporal bone" EXACT [AUTO:patterns/pat is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001695 ! squamous part of temporal bone -relationship: inheres_in UBERON:0001695 ! squamous part of temporal bone +intersection_of: RO:0000052 UBERON:0001695 ! inheres in squamous part of temporal bone +relationship: RO:0000052 UBERON:0001695 ! inheres in squamous part of temporal bone [Term] id: OBA:VT0004425 @@ -183533,7 +284686,7 @@ synonym: "morphology of otolith organ" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000782 ! otolith organ quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002518 ! otolith organ +intersection_of: RO:0000052 UBERON:0002518 ! inheres in otolith organ [Term] id: OBA:VT0004426 @@ -183543,8 +284696,8 @@ synonym: "morphology of cochlear labyrinth" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002499 ! cochlear labyrinth -relationship: inheres_in UBERON:0002499 ! cochlear labyrinth +intersection_of: RO:0000052 UBERON:0002499 ! inheres in cochlear labyrinth +relationship: RO:0000052 UBERON:0002499 ! inheres in cochlear labyrinth [Term] id: OBA:VT0004427 @@ -183554,7 +284707,7 @@ synonym: "morphology of vestibular labyrinth" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000697 ! vestibular labyrinth quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001862 ! vestibular labyrinth +intersection_of: RO:0000052 UBERON:0001862 ! inheres in vestibular labyrinth [Term] id: OBA:VT0004430 @@ -183563,8 +284716,8 @@ def: "The morphology of a Claudius cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of Claudius cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000634 ! Claudius cell -relationship: inheres_in CL:0000634 ! Claudius cell +intersection_of: RO:0000052 CL:0000634 ! inheres in Claudius cell +relationship: RO:0000052 CL:0000634 ! inheres in Claudius cell [Term] id: OBA:VT0004432 @@ -183573,8 +284726,8 @@ def: "The functionality of a auditory hair cell." [AUTO:patterns/patterns/entity synonym: "functionality of auditory hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003879 ! hair cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000202 ! auditory hair cell -relationship: inheres_in CL:0000202 ! auditory hair cell +intersection_of: RO:0000052 CL:0000202 ! inheres in auditory hair cell +relationship: RO:0000052 CL:0000202 ! inheres in auditory hair cell [Term] id: OBA:VT0004433 @@ -183583,8 +284736,8 @@ def: "The functionality of a cochlear inner hair cell." [AUTO:patterns/patterns/ synonym: "functionality of cochlear inner hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004432 ! cochlear hair cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000589 ! cochlear inner hair cell -relationship: inheres_in CL:0000589 ! cochlear inner hair cell +intersection_of: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell +relationship: RO:0000052 CL:0000589 ! inheres in cochlear inner hair cell [Term] id: OBA:VT0004434 @@ -183593,8 +284746,8 @@ def: "The functionality of a cochlear outer hair cell." [AUTO:patterns/patterns/ synonym: "functionality of cochlear outer hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004432 ! cochlear hair cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell -relationship: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell +relationship: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:VT0004438 @@ -183603,8 +284756,8 @@ def: "The functionality of a vestibular hair cell." [AUTO:patterns/patterns/enti synonym: "functionality of vestibular hair cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003879 ! hair cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000609 ! vestibular hair cell -relationship: inheres_in CL:0000609 ! vestibular hair cell +intersection_of: RO:0000052 CL:0000609 ! inheres in vestibular hair cell +relationship: RO:0000052 CL:0000609 ! inheres in vestibular hair cell [Term] id: OBA:VT0004448 @@ -183614,8 +284767,8 @@ synonym: "morphology of presphenoid bone" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008828 ! presphenoid bone -relationship: inheres_in UBERON:0008828 ! presphenoid bone +intersection_of: RO:0000052 UBERON:0008828 ! inheres in presphenoid bone +relationship: RO:0000052 UBERON:0008828 ! inheres in presphenoid bone [Term] id: OBA:VT0004452 @@ -183625,8 +284778,8 @@ synonym: "morphology of sphenoid bone pterygoid process" EXACT [AUTO:patterns/pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004649 ! sphenoid bone pterygoid process -relationship: inheres_in UBERON:0004649 ! sphenoid bone pterygoid process +intersection_of: RO:0000052 UBERON:0004649 ! inheres in sphenoid bone pterygoid process +relationship: RO:0000052 UBERON:0004649 ! inheres in sphenoid bone pterygoid process [Term] id: OBA:VT0004453 @@ -183637,8 +284790,8 @@ is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010389 ! pterygoid bone -relationship: inheres_in UBERON:0010389 ! pterygoid bone +intersection_of: RO:0000052 UBERON:0010389 ! inheres in pterygoid bone +relationship: RO:0000052 UBERON:0010389 ! inheres in pterygoid bone [Term] id: OBA:VT0004457 @@ -183648,8 +284801,8 @@ synonym: "morphology of orbitosphenoid" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002478 ! orbitosphenoid -relationship: inheres_in UBERON:0002478 ! orbitosphenoid +intersection_of: RO:0000052 UBERON:0002478 ! inheres in orbitosphenoid +relationship: RO:0000052 UBERON:0002478 ! inheres in orbitosphenoid [Term] id: OBA:VT0004466 @@ -183660,7 +284813,7 @@ is_a: OBA:VT0004399 ! cochlear outer hair cell morphology trait is_a: OBA:VT0005603 ! neuron size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in CL:0000601 ! cochlear outer hair cell +intersection_of: RO:0000052 CL:0000601 ! inheres in cochlear outer hair cell [Term] id: OBA:VT0004469 @@ -183670,7 +284823,7 @@ synonym: "morphology of zygomatic arch" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000511 ! zygomatic arch quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002500 ! zygomatic arch +intersection_of: RO:0000052 UBERON:0002500 ! inheres in zygomatic arch [Term] id: OBA:VT0004479 @@ -183680,8 +284833,8 @@ synonym: "morphology of oval window" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002501 ! oval window -relationship: inheres_in UBERON:0002501 ! oval window +intersection_of: RO:0000052 UBERON:0002501 ! inheres in oval window +relationship: RO:0000052 UBERON:0002501 ! inheres in oval window [Term] id: OBA:VT0004480 @@ -183691,8 +284844,8 @@ synonym: "morphology of round window of inner ear" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002502 ! round window of inner ear -relationship: inheres_in UBERON:0002502 ! round window of inner ear +intersection_of: RO:0000052 UBERON:0002502 ! inheres in round window of inner ear +relationship: RO:0000052 UBERON:0002502 ! inheres in round window of inner ear [Term] id: OBA:VT0004481 @@ -183702,8 +284855,8 @@ synonym: "morphology of epithelium of conjunctiva" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006763 ! epithelium of conjunctiva -relationship: inheres_in UBERON:0006763 ! epithelium of conjunctiva +intersection_of: RO:0000052 UBERON:0006763 ! inheres in epithelium of conjunctiva +relationship: RO:0000052 UBERON:0006763 ! inheres in epithelium of conjunctiva [Term] id: OBA:VT0004482 @@ -183712,8 +284865,8 @@ def: "The morphology of a interdental cell of cochlea." [AUTO:patterns/patterns/ synonym: "morphology of interdental cell of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002172 ! interdental cell of cochlea -relationship: inheres_in CL:0002172 ! interdental cell of cochlea +intersection_of: RO:0000052 CL:0002172 ! inheres in interdental cell of cochlea +relationship: RO:0000052 CL:0002172 ! inheres in interdental cell of cochlea [Term] id: OBA:VT0004493 @@ -183723,7 +284876,7 @@ synonym: "size of cochlea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000031 ! cochlea morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001844 ! cochlea +intersection_of: RO:0000052 UBERON:0001844 ! inheres in cochlea [Term] id: OBA:VT0004816 @@ -183732,8 +284885,8 @@ def: "The quality of a isotype switching." [AUTO:patterns/patterns/entity_attrib synonym: "quality of isotype switching" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045190 ! isotype switching -relationship: inheres_in GO:0045190 ! isotype switching +intersection_of: RO:0000052 GO:0045190 ! inheres in isotype switching +relationship: RO:0000052 GO:0045190 ! inheres in isotype switching [Term] id: OBA:VT0004917 @@ -183742,8 +284895,8 @@ def: "The quality of a T cell selection." [AUTO:patterns/patterns/entity_attribu synonym: "quality of T cell selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045058 ! T cell selection -relationship: inheres_in GO:0045058 ! T cell selection +intersection_of: RO:0000052 GO:0045058 ! inheres in T cell selection +relationship: RO:0000052 GO:0045058 ! inheres in T cell selection [Term] id: OBA:VT0004918 @@ -183752,8 +284905,8 @@ def: "The quality of a negative T cell selection." [AUTO:patterns/patterns/entit synonym: "quality of negative T cell selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004917 ! T cell selection trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043383 ! negative T cell selection -relationship: inheres_in GO:0043383 ! negative T cell selection +intersection_of: RO:0000052 GO:0043383 ! inheres in negative T cell selection +relationship: RO:0000052 GO:0043383 ! inheres in negative T cell selection [Term] id: OBA:VT0004919 @@ -183762,8 +284915,8 @@ def: "The quality of a positive T cell selection." [AUTO:patterns/patterns/entit synonym: "quality of positive T cell selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004917 ! T cell selection trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0043368 ! positive T cell selection -relationship: inheres_in GO:0043368 ! positive T cell selection +intersection_of: RO:0000052 GO:0043368 ! inheres in positive T cell selection +relationship: RO:0000052 GO:0043368 ! inheres in positive T cell selection [Term] id: OBA:VT0004939 @@ -183773,7 +284926,7 @@ synonym: "morphology of B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000574 ! B cell quality is_a: OBA:VT0002619 ! lymphocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000236 ! B cell +intersection_of: RO:0000052 CL:0000236 ! inheres in B cell [Term] id: OBA:VT0004940 @@ -183782,8 +284935,8 @@ def: "The morphology of a B-1 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of B-1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000819 ! B-1 B cell -relationship: inheres_in CL:0000819 ! B-1 B cell +intersection_of: RO:0000052 CL:0000819 ! inheres in B-1 B cell +relationship: RO:0000052 CL:0000819 ! inheres in B-1 B cell [Term] id: OBA:VT0004941 @@ -183792,8 +284945,8 @@ def: "The morphology of a regulatory T cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of regulatory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000815 ! regulatory T cell -relationship: inheres_in CL:0000815 ! regulatory T cell +intersection_of: RO:0000052 CL:0000815 ! inheres in regulatory T cell +relationship: RO:0000052 CL:0000815 ! inheres in regulatory T cell [Term] id: OBA:VT0004942 @@ -183802,8 +284955,8 @@ def: "The quality of a B cell selection." [AUTO:patterns/patterns/entity_attribu synonym: "quality of B cell selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002339 ! B cell selection -relationship: inheres_in GO:0002339 ! B cell selection +intersection_of: RO:0000052 GO:0002339 ! inheres in B cell selection +relationship: RO:0000052 GO:0002339 ! inheres in B cell selection [Term] id: OBA:VT0004943 @@ -183812,8 +284965,8 @@ def: "The quality of a B cell positive selection." [AUTO:patterns/patterns/entit synonym: "quality of B cell positive selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004942 ! B cell selection trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002346 ! B cell positive selection -relationship: inheres_in GO:0002346 ! B cell positive selection +intersection_of: RO:0000052 GO:0002346 ! inheres in B cell positive selection +relationship: RO:0000052 GO:0002346 ! inheres in B cell positive selection [Term] id: OBA:VT0004944 @@ -183822,8 +284975,8 @@ def: "The quality of a B cell negative selection." [AUTO:patterns/patterns/entit synonym: "quality of B cell negative selection" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004942 ! B cell selection trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002352 ! B cell negative selection -relationship: inheres_in GO:0002352 ! B cell negative selection +intersection_of: RO:0000052 GO:0002352 ! inheres in B cell negative selection +relationship: RO:0000052 GO:0002352 ! inheres in B cell negative selection [Term] id: OBA:VT0004946 @@ -183832,8 +284985,8 @@ def: "The functionality of a regulatory T cell." [AUTO:patterns/patterns/entity_ synonym: "functionality of regulatory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000815 ! regulatory T cell -relationship: inheres_in CL:0000815 ! regulatory T cell +intersection_of: RO:0000052 CL:0000815 ! inheres in regulatory T cell +relationship: RO:0000052 CL:0000815 ! inheres in regulatory T cell [Term] id: OBA:VT0004951 @@ -183843,8 +284996,8 @@ synonym: "mass of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:VT0004954 @@ -183854,8 +285007,8 @@ synonym: "mass of thymus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002370 ! thymus -relationship: inheres_in UBERON:0002370 ! thymus +intersection_of: RO:0000052 UBERON:0002370 ! inheres in thymus +relationship: RO:0000052 UBERON:0002370 ! inheres in thymus [Term] id: OBA:VT0004972 @@ -183864,8 +285017,8 @@ def: "The has number of of a regulatory T cell." [AUTO:patterns/patterns/entity_ synonym: "has number of of regulatory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000815 ! regulatory T cell -relationship: inheres_in CL:0000815 ! regulatory T cell +intersection_of: RO:0000052 CL:0000815 ! inheres in regulatory T cell +relationship: RO:0000052 CL:0000815 ! inheres in regulatory T cell [Term] id: OBA:VT0004976 @@ -183874,8 +285027,8 @@ def: "The has number of of a B-1 B cell." [AUTO:patterns/patterns/entity_attribu synonym: "has number of of B-1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000819 ! B-1 B cell -relationship: inheres_in CL:0000819 ! B-1 B cell +intersection_of: RO:0000052 CL:0000819 ! inheres in B-1 B cell +relationship: RO:0000052 CL:0000819 ! inheres in B-1 B cell [Term] id: OBA:VT0005004 @@ -183884,8 +285037,8 @@ def: "The quality of a lymphocyte anergy." [AUTO:patterns/patterns/entity_attrib synonym: "quality of lymphocyte anergy" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002249 ! lymphocyte anergy -relationship: inheres_in GO:0002249 ! lymphocyte anergy +intersection_of: RO:0000052 GO:0002249 ! inheres in lymphocyte anergy +relationship: RO:0000052 GO:0002249 ! inheres in lymphocyte anergy [Term] id: OBA:VT0005006 @@ -183894,8 +285047,8 @@ def: "The functionality of a osteoblast." [AUTO:patterns/patterns/entity_attribu synonym: "functionality of osteoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000062 ! osteoblast -relationship: inheres_in CL:0000062 ! osteoblast +intersection_of: RO:0000052 CL:0000062 ! inheres in osteoblast +relationship: RO:0000052 CL:0000062 ! inheres in osteoblast [Term] id: OBA:VT0005007 @@ -183905,8 +285058,8 @@ synonym: "mass density of bone element" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001019 ! mass density intersection_of: PATO:0001019 ! mass density -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:VT0005008 @@ -183915,8 +285068,8 @@ def: "The quality of a osteoblast development." [AUTO:patterns/patterns/entity_a synonym: "quality of osteoblast development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002076 ! osteoblast development -relationship: inheres_in GO:0002076 ! osteoblast development +intersection_of: RO:0000052 GO:0002076 ! inheres in osteoblast development +relationship: RO:0000052 GO:0002076 ! inheres in osteoblast development [Term] id: OBA:VT0005019 @@ -183925,8 +285078,8 @@ def: "The morphology of a early pro-B cell." [AUTO:patterns/patterns/entity_attr synonym: "morphology of early pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005432 ! pro-B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002046 ! early pro-B cell -relationship: inheres_in CL:0002046 ! early pro-B cell +intersection_of: RO:0000052 CL:0002046 ! inheres in early pro-B cell +relationship: RO:0000052 CL:0002046 ! inheres in early pro-B cell [Term] id: OBA:VT0005020 @@ -183935,8 +285088,8 @@ def: "The morphology of a late pro-B cell." [AUTO:patterns/patterns/entity_attri synonym: "morphology of late pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004939 ! B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002048 ! late pro-B cell -relationship: inheres_in CL:0002048 ! late pro-B cell +intersection_of: RO:0000052 CL:0002048 ! inheres in late pro-B cell +relationship: RO:0000052 CL:0002048 ! inheres in late pro-B cell [Term] id: OBA:VT0005022 @@ -183945,8 +285098,8 @@ def: "The morphology of a immature B cell." [AUTO:patterns/patterns/entity_attri synonym: "morphology of immature B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004939 ! B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000816 ! immature B cell -relationship: inheres_in CL:0000816 ! immature B cell +intersection_of: RO:0000052 CL:0000816 ! inheres in immature B cell +relationship: RO:0000052 CL:0000816 ! inheres in immature B cell [Term] id: OBA:VT0005028 @@ -183956,8 +285109,8 @@ synonym: "morphology of trophectoderm" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004345 ! trophectoderm -relationship: inheres_in UBERON:0004345 ! trophectoderm +intersection_of: RO:0000052 UBERON:0004345 ! inheres in trophectoderm +relationship: RO:0000052 UBERON:0004345 ! inheres in trophectoderm [Term] id: OBA:VT0005029 @@ -183967,8 +285120,8 @@ synonym: "morphology of amnion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000305 ! amnion -relationship: inheres_in UBERON:0000305 ! amnion +intersection_of: RO:0000052 UBERON:0000305 ! inheres in amnion +relationship: RO:0000052 UBERON:0000305 ! inheres in amnion [Term] id: OBA:VT0005031 @@ -183978,8 +285131,8 @@ synonym: "morphology of trophoblast" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000088 ! trophoblast -relationship: inheres_in UBERON:0000088 ! trophoblast +intersection_of: RO:0000052 UBERON:0000088 ! inheres in trophoblast +relationship: RO:0000052 UBERON:0000088 ! inheres in trophoblast [Term] id: OBA:VT0005032 @@ -183989,8 +285142,8 @@ synonym: "morphology of ectoplacental cone" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004364 ! ectoplacental cone -relationship: inheres_in UBERON:0004364 ! ectoplacental cone +intersection_of: RO:0000052 UBERON:0004364 ! inheres in ectoplacental cone +relationship: RO:0000052 UBERON:0004364 ! inheres in ectoplacental cone [Term] id: OBA:VT0005033 @@ -183999,8 +285152,8 @@ def: "The morphology of a trophoblast giant cell." [AUTO:patterns/patterns/entit synonym: "morphology of trophoblast giant cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002488 ! trophoblast giant cell -relationship: inheres_in CL:0002488 ! trophoblast giant cell +intersection_of: RO:0000052 CL:0002488 ! inheres in trophoblast giant cell +relationship: RO:0000052 CL:0002488 ! inheres in trophoblast giant cell [Term] id: OBA:VT0005034 @@ -184010,8 +285163,8 @@ synonym: "morphology of anus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001245 ! anus -relationship: inheres_in UBERON:0001245 ! anus +intersection_of: RO:0000052 UBERON:0001245 ! inheres in anus +relationship: RO:0000052 UBERON:0001245 ! inheres in anus [Term] id: OBA:VT0005045 @@ -184021,7 +285174,7 @@ synonym: "area of cortex of thymus" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0003540 ! cortex of thymus size is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0002123 ! cortex of thymus +intersection_of: RO:0000052 UBERON:0002123 ! inheres in cortex of thymus [Term] id: OBA:VT0005061 @@ -184030,8 +285183,8 @@ def: "The morphology of a eosinophil." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of eosinophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002441 ! granulocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000771 ! eosinophil -relationship: inheres_in CL:0000771 ! eosinophil +intersection_of: RO:0000052 CL:0000771 ! inheres in eosinophil +relationship: RO:0000052 CL:0000771 ! inheres in eosinophil [Term] id: OBA:VT0005065 @@ -184040,8 +285193,8 @@ def: "The morphology of a neutrophil." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of neutrophil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002441 ! granulocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000775 ! neutrophil -relationship: inheres_in CL:0000775 ! neutrophil +intersection_of: RO:0000052 CL:0000775 ! inheres in neutrophil +relationship: RO:0000052 CL:0000775 ! inheres in neutrophil [Term] id: OBA:VT0005068 @@ -184051,7 +285204,7 @@ synonym: "morphology of natural killer cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000559 ! natural killer cell quality is_a: OBA:VT0002619 ! lymphocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000623 ! natural killer cell +intersection_of: RO:0000052 CL:0000623 ! inheres in natural killer cell [Term] id: OBA:VT0005069 @@ -184061,7 +285214,7 @@ synonym: "functionality of natural killer cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000559 ! natural killer cell quality is_a: OBA:VT0003945 ! lymphocyte physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000623 ! natural killer cell +intersection_of: RO:0000052 CL:0000623 ! inheres in natural killer cell [Term] id: OBA:VT0005078 @@ -184070,8 +285223,8 @@ def: "The functionality of a cytotoxic T cell." [AUTO:patterns/patterns/entity_a synonym: "functionality of cytotoxic T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000910 ! cytotoxic T cell -relationship: inheres_in CL:0000910 ! cytotoxic T cell +intersection_of: RO:0000052 CL:0000910 ! inheres in cytotoxic T cell +relationship: RO:0000052 CL:0000910 ! inheres in cytotoxic T cell [Term] id: OBA:VT0005081 @@ -184080,8 +285233,8 @@ def: "The morphology of a reticular layer of dermis." [AUTO:patterns/patterns/en synonym: "morphology of reticular layer of dermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001993 ! reticular layer of dermis -relationship: inheres_in UBERON:0001993 ! reticular layer of dermis +intersection_of: RO:0000052 UBERON:0001993 ! inheres in reticular layer of dermis +relationship: RO:0000052 UBERON:0001993 ! inheres in reticular layer of dermis [Term] id: OBA:VT0005082 @@ -184090,8 +285243,8 @@ def: "The morphology of a stratum lucidum of epidermis." [AUTO:patterns/patterns synonym: "morphology of stratum lucidum of epidermis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT4000009 ! skin layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002071 ! stratum lucidum of epidermis -relationship: inheres_in UBERON:0002071 ! stratum lucidum of epidermis +intersection_of: RO:0000052 UBERON:0002071 ! inheres in stratum lucidum of epidermis +relationship: RO:0000052 UBERON:0002071 ! inheres in stratum lucidum of epidermis [Term] id: OBA:VT0005083 @@ -184101,7 +285254,7 @@ synonym: "morphology of biliary tree" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000184 ! biliary tree quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001173 ! biliary tree +intersection_of: RO:0000052 UBERON:0001173 ! inheres in biliary tree [Term] id: OBA:VT0005084 @@ -184111,8 +285264,8 @@ synonym: "morphology of gall bladder" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002110 ! gall bladder -relationship: inheres_in UBERON:0002110 ! gall bladder +intersection_of: RO:0000052 UBERON:0002110 ! inheres in gall bladder +relationship: RO:0000052 UBERON:0002110 ! inheres in gall bladder [Term] id: OBA:VT0005085 @@ -184122,19 +285275,18 @@ synonym: "functionality of gall bladder" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002110 ! gall bladder -relationship: inheres_in UBERON:0002110 ! gall bladder +intersection_of: RO:0000052 UBERON:0002110 ! inheres in gall bladder +relationship: RO:0000052 UBERON:0002110 ! inheres in gall bladder [Term] id: OBA:VT0005086 name: bile amount def: "The volume of a bile." [AUTO:patterns/patterns/entity_attribute] synonym: "volume of bile" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0100003 ! anatomical entity attribute -is_a: PATO:0000918 ! volume +is_a: OBA:0000036 ! body fluid levels intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001970 ! bile -relationship: inheres_in UBERON:0001970 ! bile +intersection_of: RO:0000052 UBERON:0001970 ! inheres in bile +relationship: RO:0000052 UBERON:0001970 ! inheres in bile [Term] id: OBA:VT0005089 @@ -184143,8 +285295,8 @@ def: "The amount of a double negative thymocyte." [AUTO:patterns/patterns/entity synonym: "amount of double negative thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003541 ! thymocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002489 ! double negative thymocyte -relationship: inheres_in CL:0002489 ! double negative thymocyte +intersection_of: RO:0000052 CL:0002489 ! inheres in double negative thymocyte +relationship: RO:0000052 CL:0002489 ! inheres in double negative thymocyte [Term] id: OBA:VT0005096 @@ -184153,8 +285305,8 @@ def: "The amount of a erythroblast." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of erythroblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005899 ! myeloid cell amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000765 ! erythroblast -relationship: inheres_in CL:0000765 ! erythroblast +intersection_of: RO:0000052 CL:0000765 ! inheres in erythroblast +relationship: RO:0000052 CL:0000765 ! inheres in erythroblast [Term] id: OBA:VT0005098 @@ -184164,8 +285316,8 @@ synonym: "morphology of optic choroid" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000156 ! vasculature of eye quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001776 ! optic choroid -relationship: inheres_in UBERON:0001776 ! optic choroid +intersection_of: RO:0000052 UBERON:0001776 ! inheres in optic choroid +relationship: RO:0000052 UBERON:0001776 ! inheres in optic choroid [Term] id: OBA:VT0005099 @@ -184175,8 +285327,8 @@ synonym: "morphology of ciliary body" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001775 ! ciliary body -relationship: inheres_in UBERON:0001775 ! ciliary body +intersection_of: RO:0000052 UBERON:0001775 ! inheres in ciliary body +relationship: RO:0000052 UBERON:0001775 ! inheres in ciliary body [Term] id: OBA:VT0005104 @@ -184186,8 +285338,8 @@ synonym: "morphology of tarsal region" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004454 ! tarsal region -relationship: inheres_in UBERON:0004454 ! tarsal region +intersection_of: RO:0000052 UBERON:0004454 ! inheres in tarsal region +relationship: RO:0000052 UBERON:0004454 ! inheres in tarsal region [Term] id: OBA:VT0005105 @@ -184197,7 +285349,7 @@ synonym: "morphology of auditory ossicle bone" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000265 ! auditory ossicle bone quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001686 ! auditory ossicle bone +intersection_of: RO:0000052 UBERON:0001686 ! inheres in auditory ossicle bone [Term] id: OBA:VT0005106 @@ -184208,7 +285360,7 @@ is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000234 ! incus bone quality is_a: OBA:VT0005105 ! auditory ossicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001688 ! incus bone +intersection_of: RO:0000052 UBERON:0001688 ! inheres in incus bone [Term] id: OBA:VT0005107 @@ -184218,8 +285370,8 @@ synonym: "morphology of stapes bone" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:VT0005105 ! auditory ossicle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001687 ! stapes bone -relationship: inheres_in UBERON:0001687 ! stapes bone +intersection_of: RO:0000052 UBERON:0001687 ! inheres in stapes bone +relationship: RO:0000052 UBERON:0001687 ! inheres in stapes bone [Term] id: OBA:VT0005108 @@ -184230,7 +285382,7 @@ is_a: OBA:0002478 ! forelimb zeugopod bone morphology is_a: OBA:1000300 ! ulna quality is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001424 ! ulna +intersection_of: RO:0000052 UBERON:0001424 ! inheres in ulna [Term] id: OBA:VT0005109 @@ -184240,7 +285392,7 @@ synonym: "morphology of talus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002810 ! tarsal bone morphology is_a: OBA:1000449 ! talus quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002395 ! talus +intersection_of: RO:0000052 UBERON:0002395 ! inheres in talus [Term] id: OBA:VT0005110 @@ -184250,7 +285402,7 @@ synonym: "size of talus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002564 ! tarsal bone size is_a: OBA:VT0005109 ! talus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002395 ! talus +intersection_of: RO:0000052 UBERON:0002395 ! inheres in talus [Term] id: OBA:VT0005112 @@ -184260,8 +285412,8 @@ synonym: "morphology of ventral horn of spinal cord" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002257 ! ventral horn of spinal cord -relationship: inheres_in UBERON:0002257 ! ventral horn of spinal cord +intersection_of: RO:0000052 UBERON:0002257 ! inheres in ventral horn of spinal cord +relationship: RO:0000052 UBERON:0002257 ! inheres in ventral horn of spinal cord [Term] id: OBA:VT0005113 @@ -184270,8 +285422,8 @@ def: "The amount of a motor neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of motor neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015026 ! neuron quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000100 ! motor neuron -relationship: inheres_in CL:0000100 ! motor neuron +intersection_of: RO:0000052 CL:0000100 ! inheres in motor neuron +relationship: RO:0000052 CL:0000100 ! inheres in motor neuron [Term] id: OBA:VT0005120 @@ -184295,8 +285447,8 @@ def: "The morphology of a gubernaculum (male or female)." [AUTO:patterns/pattern synonym: "morphology of gubernaculum (male or female)" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005504 ! ligament morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004346 ! gubernaculum (male or female) -relationship: inheres_in UBERON:0004346 ! gubernaculum (male or female) +intersection_of: RO:0000052 UBERON:0004346 ! inheres in gubernaculum (male or female) +relationship: RO:0000052 UBERON:0004346 ! inheres in gubernaculum (male or female) [Term] id: OBA:VT0005153 @@ -184305,8 +285457,8 @@ def: "The quality of a B cell proliferation." [AUTO:patterns/patterns/entity_att synonym: "quality of B cell proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010184 ! lymphocyte proliferation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042100 ! B cell proliferation -relationship: inheres_in GO:0042100 ! B cell proliferation +intersection_of: RO:0000052 GO:0042100 ! inheres in B cell proliferation +relationship: RO:0000052 GO:0042100 ! inheres in B cell proliferation [Term] id: OBA:VT0005160 @@ -184323,7 +285475,7 @@ synonym: "female of http://purl.obolibrary.org/obo/GO_0007126" EXACT [AUTO:patte is_a: OBA:VT0001930 ! meiosis trait is_a: PATO:0000383 ! female intersection_of: PATO:0000383 ! female -intersection_of: inheres_in GO:0007126 +intersection_of: RO:0000052 GO:0007126 ! inheres in [Term] id: OBA:VT0005169 @@ -184333,7 +285485,7 @@ synonym: "male of http://purl.obolibrary.org/obo/GO_0007126" EXACT [AUTO:pattern is_a: OBA:VT0001930 ! meiosis trait is_a: PATO:0000384 ! male intersection_of: PATO:0000384 ! male -intersection_of: inheres_in GO:0007126 +intersection_of: RO:0000052 GO:0007126 ! inheres in [Term] id: OBA:VT0005180 @@ -184368,8 +285520,8 @@ def: "The morphology of a penis." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of penis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004643 ! male reproductive organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000989 ! penis -relationship: inheres_in UBERON:0000989 ! penis +intersection_of: RO:0000052 UBERON:0000989 ! inheres in penis +relationship: RO:0000052 UBERON:0000989 ! inheres in penis [Term] id: OBA:VT0005189 @@ -184380,7 +285532,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003315 ! perineum morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002356 ! perineum +intersection_of: RO:0000052 UBERON:0002356 ! inheres in perineum [Term] id: OBA:VT0005193 @@ -184390,7 +285542,7 @@ synonym: "morphology of anterior segment of eyeball" EXACT [AUTO:patterns/patter is_a: OBA:1000390 ! anterior segment of eyeball quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001801 ! anterior segment of eyeball +intersection_of: RO:0000052 UBERON:0001801 ! inheres in anterior segment of eyeball [Term] id: OBA:VT0005194 @@ -184400,8 +285552,8 @@ synonym: "morphology of anterior uvea" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011892 ! anterior uvea -relationship: inheres_in UBERON:0011892 ! anterior uvea +intersection_of: RO:0000052 UBERON:0011892 ! inheres in anterior uvea +relationship: RO:0000052 UBERON:0011892 ! inheres in anterior uvea [Term] id: OBA:VT0005195 @@ -184411,7 +285563,7 @@ synonym: "morphology of posterior segment of eyeball" EXACT [AUTO:patterns/patte is_a: OBA:1000547 ! posterior segment of eyeball quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001802 ! posterior segment of eyeball +intersection_of: RO:0000052 UBERON:0001802 ! inheres in posterior segment of eyeball [Term] id: OBA:VT0005197 @@ -184421,8 +285573,8 @@ synonym: "morphology of uvea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001768 ! uvea -relationship: inheres_in UBERON:0001768 ! uvea +intersection_of: RO:0000052 UBERON:0001768 ! inheres in uvea +relationship: RO:0000052 UBERON:0001768 ! inheres in uvea [Term] id: OBA:VT0005198 @@ -184432,8 +285584,8 @@ synonym: "morphology of aqueous drainage system" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0015074 ! organ system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003956 ! aqueous drainage system -relationship: inheres_in UBERON:0003956 ! aqueous drainage system +intersection_of: RO:0000052 UBERON:0003956 ! inheres in aqueous drainage system +relationship: RO:0000052 UBERON:0003956 ! inheres in aqueous drainage system [Term] id: OBA:VT0005201 @@ -184442,8 +285594,8 @@ def: "The morphology of a pigmented layer of retina." [AUTO:patterns/patterns/en synonym: "morphology of pigmented layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001782 ! pigmented layer of retina -relationship: inheres_in UBERON:0001782 ! pigmented layer of retina +intersection_of: RO:0000052 UBERON:0001782 ! inheres in pigmented layer of retina +relationship: RO:0000052 UBERON:0001782 ! inheres in pigmented layer of retina [Term] id: OBA:VT0005203 @@ -184453,8 +285605,8 @@ synonym: "morphology of eye trabecular meshwork" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005969 ! eye trabecular meshwork -relationship: inheres_in UBERON:0005969 ! eye trabecular meshwork +intersection_of: RO:0000052 UBERON:0005969 ! inheres in eye trabecular meshwork +relationship: RO:0000052 UBERON:0005969 ! inheres in eye trabecular meshwork [Term] id: OBA:VT0005204 @@ -184464,8 +285616,8 @@ synonym: "morphology of canal of Schlemm" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004029 ! canal of Schlemm -relationship: inheres_in UBERON:0004029 ! canal of Schlemm +intersection_of: RO:0000052 UBERON:0004029 ! inheres in canal of Schlemm +relationship: RO:0000052 UBERON:0004029 ! inheres in canal of Schlemm [Term] id: OBA:VT0005205 @@ -184475,7 +285627,7 @@ synonym: "morphology of anterior chamber of eyeball" EXACT [AUTO:patterns/patter is_a: OBA:1000241 ! anterior chamber of eyeball quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001766 ! anterior chamber of eyeball +intersection_of: RO:0000052 UBERON:0001766 ! inheres in anterior chamber of eyeball [Term] id: OBA:VT0005206 @@ -184485,8 +285637,8 @@ synonym: "morphology of aqueous humor of eyeball" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001796 ! aqueous humor of eyeball -relationship: inheres_in UBERON:0001796 ! aqueous humor of eyeball +intersection_of: RO:0000052 UBERON:0001796 ! inheres in aqueous humor of eyeball +relationship: RO:0000052 UBERON:0001796 ! inheres in aqueous humor of eyeball [Term] id: OBA:VT0005207 @@ -184496,8 +285648,8 @@ synonym: "morphology of aqueous vein" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004030 ! aqueous vein -relationship: inheres_in UBERON:0004030 ! aqueous vein +intersection_of: RO:0000052 UBERON:0004030 ! inheres in aqueous vein +relationship: RO:0000052 UBERON:0004030 ! inheres in aqueous vein [Term] id: OBA:VT0005208 @@ -184507,8 +285659,8 @@ synonym: "morphology of iris stroma" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001779 ! iris stroma -relationship: inheres_in UBERON:0001779 ! iris stroma +intersection_of: RO:0000052 UBERON:0001779 ! inheres in iris stroma +relationship: RO:0000052 UBERON:0001779 ! inheres in iris stroma [Term] id: OBA:VT0005209 @@ -184518,8 +285670,8 @@ synonym: "morphology of mucosa of stomach" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001199 ! mucosa of stomach -relationship: inheres_in UBERON:0001199 ! mucosa of stomach +intersection_of: RO:0000052 UBERON:0001199 ! inheres in mucosa of stomach +relationship: RO:0000052 UBERON:0001199 ! inheres in mucosa of stomach [Term] id: OBA:VT0005211 @@ -184529,7 +285681,7 @@ synonym: "thickness of mucosa of stomach" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0005209 ! mucosa of stomach size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001199 ! mucosa of stomach +intersection_of: RO:0000052 UBERON:0001199 ! inheres in mucosa of stomach [Term] id: OBA:VT0005215 @@ -184539,8 +285691,8 @@ synonym: "morphology of islet of Langerhans" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000006 ! islet of Langerhans -relationship: inheres_in UBERON:0000006 ! islet of Langerhans +intersection_of: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans +relationship: RO:0000052 UBERON:0000006 ! inheres in islet of Langerhans [Term] id: OBA:VT0005216 @@ -184549,8 +285701,8 @@ def: "The morphology of a pancreatic A cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of pancreatic A cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000171 ! pancreatic A cell -relationship: inheres_in CL:0000171 ! pancreatic A cell +intersection_of: RO:0000052 CL:0000171 ! inheres in pancreatic A cell +relationship: RO:0000052 CL:0000171 ! inheres in pancreatic A cell [Term] id: OBA:VT0005217 @@ -184559,8 +285711,8 @@ def: "The morphology of a type B pancreatic cell." [AUTO:patterns/patterns/entit synonym: "morphology of type B pancreatic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000169 ! type B pancreatic cell -relationship: inheres_in CL:0000169 ! type B pancreatic cell +intersection_of: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell +relationship: RO:0000052 CL:0000169 ! inheres in type B pancreatic cell [Term] id: OBA:VT0005218 @@ -184569,8 +285721,8 @@ def: "The morphology of a pancreatic D cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of pancreatic D cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004141 ! enteroendocrine cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000173 ! pancreatic D cell -relationship: inheres_in CL:0000173 ! pancreatic D cell +intersection_of: RO:0000052 CL:0000173 ! inheres in pancreatic D cell +relationship: RO:0000052 CL:0000173 ! inheres in pancreatic D cell [Term] id: OBA:VT0005220 @@ -184579,8 +285731,8 @@ def: "The morphology of a exocrine pancreas." [AUTO:patterns/patterns/entity_att synonym: "morphology of exocrine pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004285 ! serous gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000017 ! exocrine pancreas -relationship: inheres_in UBERON:0000017 ! exocrine pancreas +intersection_of: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas +relationship: RO:0000052 UBERON:0000017 ! inheres in exocrine pancreas [Term] id: OBA:VT0005222 @@ -184590,7 +285742,7 @@ synonym: "size of somite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010122 ! somite morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002329 ! somite +intersection_of: RO:0000052 UBERON:0002329 ! inheres in somite [Term] id: OBA:VT0005231 @@ -184599,8 +285751,8 @@ def: "The morphology of a brachial lymph node." [AUTO:patterns/patterns/entity_a synonym: "morphology of brachial lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003703 ! lymph node morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002525 ! brachial lymph node -relationship: inheres_in UBERON:0002525 ! brachial lymph node +intersection_of: RO:0000052 UBERON:0002525 ! inheres in brachial lymph node +relationship: RO:0000052 UBERON:0002525 ! inheres in brachial lymph node [Term] id: OBA:VT0005232 @@ -184609,8 +285761,8 @@ def: "The morphology of a mesenteric lymph node." [AUTO:patterns/patterns/entity synonym: "morphology of mesenteric lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0009625 ! abdominal lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002509 ! mesenteric lymph node -relationship: inheres_in UBERON:0002509 ! mesenteric lymph node +intersection_of: RO:0000052 UBERON:0002509 ! inheres in mesenteric lymph node +relationship: RO:0000052 UBERON:0002509 ! inheres in mesenteric lymph node [Term] id: OBA:VT0005235 @@ -184620,8 +285772,8 @@ synonym: "morphology of olfactory lobe" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005366 ! olfactory lobe -relationship: inheres_in UBERON:0005366 ! olfactory lobe +intersection_of: RO:0000052 UBERON:0005366 ! inheres in olfactory lobe +relationship: RO:0000052 UBERON:0005366 ! inheres in olfactory lobe [Term] id: OBA:VT0005236 @@ -184630,8 +285782,8 @@ def: "The morphology of a olfactory nerve." [AUTO:patterns/patterns/entity_attri synonym: "morphology of olfactory nerve" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001056 ! cranial nerve morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001579 ! olfactory nerve -relationship: inheres_in UBERON:0001579 ! olfactory nerve +intersection_of: RO:0000052 UBERON:0001579 ! inheres in olfactory nerve +relationship: RO:0000052 UBERON:0001579 ! inheres in olfactory nerve [Term] id: OBA:VT0005237 @@ -184640,8 +285792,8 @@ def: "The morphology of a olfactory tract." [AUTO:patterns/patterns/entity_attri synonym: "morphology of olfactory tract" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000778 ! nervous system tract morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002265 ! olfactory tract -relationship: inheres_in UBERON:0002265 ! olfactory tract +intersection_of: RO:0000052 UBERON:0002265 ! inheres in olfactory tract +relationship: RO:0000052 UBERON:0002265 ! inheres in olfactory tract [Term] id: OBA:VT0005239 @@ -184651,8 +285803,8 @@ synonym: "morphology of Bruch's membrane" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003957 ! Bruch's membrane -relationship: inheres_in UBERON:0003957 ! Bruch's membrane +intersection_of: RO:0000052 UBERON:0003957 ! inheres in Bruch's membrane +relationship: RO:0000052 UBERON:0003957 ! inheres in Bruch's membrane [Term] id: OBA:VT0005240 @@ -184661,8 +285813,8 @@ def: "The morphology of a amacrine cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of amacrine cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006004 ! interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000561 ! amacrine cell -relationship: inheres_in CL:0000561 ! amacrine cell +intersection_of: RO:0000052 CL:0000561 ! inheres in amacrine cell +relationship: RO:0000052 CL:0000561 ! inheres in amacrine cell [Term] id: OBA:VT0005241 @@ -184671,8 +285823,8 @@ def: "The morphology of a ganglionic layer of retina." [AUTO:patterns/patterns/e synonym: "morphology of ganglionic layer of retina" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001792 ! ganglionic layer of retina -relationship: inheres_in UBERON:0001792 ! ganglionic layer of retina +intersection_of: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina +relationship: RO:0000052 UBERON:0001792 ! inheres in ganglionic layer of retina [Term] id: OBA:VT0005246 @@ -184682,7 +285834,7 @@ synonym: "morphology of orbit of skull" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000615 ! orbit of skull quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:VT0005247 @@ -184691,8 +285843,8 @@ def: "The morphology of a extra-ocular muscle." [AUTO:patterns/patterns/entity_a synonym: "morphology of extra-ocular muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003686 ! eye muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001601 ! extra-ocular muscle -relationship: inheres_in UBERON:0001601 ! extra-ocular muscle +intersection_of: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle +relationship: RO:0000052 UBERON:0001601 ! inheres in extra-ocular muscle [Term] id: OBA:VT0005248 @@ -184701,8 +285853,8 @@ def: "The morphology of a Harderian gland." [AUTO:patterns/patterns/entity_attri synonym: "morphology of Harderian gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004187 ! Harderian gland -relationship: inheres_in UBERON:0004187 ! Harderian gland +intersection_of: RO:0000052 UBERON:0004187 ! inheres in Harderian gland +relationship: RO:0000052 UBERON:0004187 ! inheres in Harderian gland [Term] id: OBA:VT0005249 @@ -184712,8 +285864,8 @@ synonym: "morphology of palatine bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001682 ! palatine bone -relationship: inheres_in UBERON:0001682 ! palatine bone +intersection_of: RO:0000052 UBERON:0001682 ! inheres in palatine bone +relationship: RO:0000052 UBERON:0001682 ! inheres in palatine bone [Term] id: OBA:VT0005250 @@ -184723,8 +285875,8 @@ synonym: "has number of of Sertoli cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000216 ! Sertoli cell -relationship: inheres_in CL:0000216 ! Sertoli cell +intersection_of: RO:0000052 CL:0000216 ! inheres in Sertoli cell +relationship: RO:0000052 CL:0000216 ! inheres in Sertoli cell [Term] id: OBA:VT0005252 @@ -184733,8 +285885,8 @@ def: "The morphology of a tarsal gland." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of tarsal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004769 ! skin sebaceous gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001818 ! tarsal gland -relationship: inheres_in UBERON:0001818 ! tarsal gland +intersection_of: RO:0000052 UBERON:0001818 ! inheres in tarsal gland +relationship: RO:0000052 UBERON:0001818 ! inheres in tarsal gland [Term] id: OBA:VT0005253 @@ -184744,8 +285896,8 @@ synonym: "functionality of camera-type eye" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000019 ! camera-type eye -relationship: inheres_in UBERON:0000019 ! camera-type eye +intersection_of: RO:0000052 UBERON:0000019 ! inheres in camera-type eye +relationship: RO:0000052 UBERON:0000019 ! inheres in camera-type eye [Term] id: OBA:VT0005267 @@ -184755,8 +285907,8 @@ synonym: "morphology of olfactory cortex" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002894 ! olfactory cortex -relationship: inheres_in UBERON:0002894 ! olfactory cortex +intersection_of: RO:0000052 UBERON:0002894 ! inheres in olfactory cortex +relationship: RO:0000052 UBERON:0002894 ! inheres in olfactory cortex [Term] id: OBA:VT0005269 @@ -184766,7 +285918,7 @@ synonym: "morphology of occipital bone" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000618 ! occipital bone quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001676 ! occipital bone +intersection_of: RO:0000052 UBERON:0001676 ! inheres in occipital bone [Term] id: OBA:VT0005270 @@ -184777,7 +285929,7 @@ is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:1000316 ! jugal bone quality is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001683 ! jugal bone +intersection_of: RO:0000052 UBERON:0001683 ! inheres in jugal bone [Term] id: OBA:VT0005271 @@ -184787,8 +285939,8 @@ synonym: "morphology of lacrimal bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000065 ! dermal bone morphology is_a: OBA:VT0002116 ! craniofacial bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001680 ! lacrimal bone -relationship: inheres_in UBERON:0001680 ! lacrimal bone +intersection_of: RO:0000052 UBERON:0001680 ! inheres in lacrimal bone +relationship: RO:0000052 UBERON:0001680 ! inheres in lacrimal bone [Term] id: OBA:VT0005272 @@ -184797,8 +285949,8 @@ def: "The morphology of a temporal bone." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of temporal bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010003 ! bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001678 ! temporal bone -relationship: inheres_in UBERON:0001678 ! temporal bone +intersection_of: RO:0000052 UBERON:0001678 ! inheres in temporal bone +relationship: RO:0000052 UBERON:0001678 ! inheres in temporal bone [Term] id: OBA:VT0005273 @@ -184808,7 +285960,7 @@ synonym: "morphology of basicranium" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:1000249 ! basicranium quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002517 ! basicranium +intersection_of: RO:0000052 UBERON:0002517 ! inheres in basicranium [Term] id: OBA:VT0005274 @@ -184818,7 +285970,7 @@ synonym: "morphology of facial skeleton" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000450 ! facial skeleton quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011156 ! facial skeleton +intersection_of: RO:0000052 UBERON:0011156 ! inheres in facial skeleton [Term] id: OBA:VT0005277 @@ -184828,8 +285980,8 @@ synonym: "morphology of brainstem" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002298 ! brainstem -relationship: inheres_in UBERON:0002298 ! brainstem +intersection_of: RO:0000052 UBERON:0002298 ! inheres in brainstem +relationship: RO:0000052 UBERON:0002298 ! inheres in brainstem [Term] id: OBA:VT0005278 @@ -184838,8 +285990,8 @@ def: "The quality of a cholesterol homeostasis." [AUTO:patterns/patterns/entity_ synonym: "quality of cholesterol homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015079 ! sterol homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042632 ! cholesterol homeostasis -relationship: inheres_in GO:0042632 ! cholesterol homeostasis +intersection_of: RO:0000052 GO:0042632 ! inheres in cholesterol homeostasis +relationship: RO:0000052 GO:0042632 ! inheres in cholesterol homeostasis [Term] id: OBA:VT0005280 @@ -184870,8 +286022,8 @@ synonym: "morphology of cardiac ventricle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002082 ! cardiac ventricle -relationship: inheres_in UBERON:0002082 ! cardiac ventricle +intersection_of: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle +relationship: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle [Term] id: OBA:VT0005296 @@ -184882,7 +286034,7 @@ is_a: OBA:0004002 ! shoulder bone morphology is_a: OBA:1000326 ! humerus quality is_a: OBA:VT0010104 ! forelimb long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0005298 @@ -184892,8 +286044,8 @@ synonym: "morphology of clavicle bone" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:VT0003723 ! long bone morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001105 ! clavicle bone -relationship: inheres_in UBERON:0001105 ! clavicle bone +intersection_of: RO:0000052 UBERON:0001105 ! inheres in clavicle bone +relationship: RO:0000052 UBERON:0001105 ! inheres in clavicle bone [Term] id: OBA:VT0005299 @@ -184903,8 +286055,8 @@ synonym: "morphology of posterior chamber of eyeball" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001767 ! posterior chamber of eyeball -relationship: inheres_in UBERON:0001767 ! posterior chamber of eyeball +intersection_of: RO:0000052 UBERON:0001767 ! inheres in posterior chamber of eyeball +relationship: RO:0000052 UBERON:0001767 ! inheres in posterior chamber of eyeball [Term] id: OBA:VT0005300 @@ -184914,7 +286066,7 @@ synonym: "morphology of substantia propria of cornea" EXACT [AUTO:patterns/patte is_a: OBA:1000551 ! substantia propria of cornea quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001777 ! substantia propria of cornea +intersection_of: RO:0000052 UBERON:0001777 ! inheres in substantia propria of cornea [Term] id: OBA:VT0005301 @@ -184924,7 +286076,7 @@ synonym: "morphology of corneal endothelium" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000195 ! corneal endothelium quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001985 ! corneal endothelium +intersection_of: RO:0000052 UBERON:0001985 ! inheres in corneal endothelium [Term] id: OBA:VT0005303 @@ -184934,8 +286086,8 @@ synonym: "functionality of urinary bladder" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001255 ! urinary bladder -relationship: inheres_in UBERON:0001255 ! urinary bladder +intersection_of: RO:0000052 UBERON:0001255 ! inheres in urinary bladder +relationship: RO:0000052 UBERON:0001255 ! inheres in urinary bladder [Term] id: OBA:VT0005305 @@ -184945,7 +286097,7 @@ synonym: "size of coagulating gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0001163 ! coagulating gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0008807 ! coagulating gland +intersection_of: RO:0000052 UBERON:0008807 ! inheres in coagulating gland [Term] id: OBA:VT0005306 @@ -184954,8 +286106,8 @@ def: "The morphology of a phalanx." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of phalanx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005468 ! limb long bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003221 ! phalanx -relationship: inheres_in UBERON:0003221 ! phalanx +intersection_of: RO:0000052 UBERON:0003221 ! inheres in phalanx +relationship: RO:0000052 UBERON:0003221 ! inheres in phalanx [Term] id: OBA:VT0005308 @@ -184971,8 +286123,8 @@ def: "The functionality of a saliva-secreting gland." [AUTO:patterns/patterns/en synonym: "functionality of saliva-secreting gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005863 ! exocrine gland functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001044 ! saliva-secreting gland -relationship: inheres_in UBERON:0001044 ! saliva-secreting gland +intersection_of: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland +relationship: RO:0000052 UBERON:0001044 ! inheres in saliva-secreting gland [Term] id: OBA:VT0005311 @@ -184988,8 +286140,8 @@ def: "The quality of a sensory perception of touch." [AUTO:patterns/patterns/ent synonym: "quality of sensory perception of touch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050975 ! sensory perception of touch -relationship: inheres_in GO:0050975 ! sensory perception of touch +intersection_of: RO:0000052 GO:0050975 ! inheres in sensory perception of touch +relationship: RO:0000052 GO:0050975 ! inheres in sensory perception of touch [Term] id: OBA:VT0005325 @@ -184998,28 +286150,28 @@ def: "The morphology of a glomerular capillary." [AUTO:patterns/patterns/entity_ synonym: "morphology of glomerular capillary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005386 ! kidney capillary morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004212 ! glomerular capillary -relationship: inheres_in UBERON:0004212 ! glomerular capillary +intersection_of: RO:0000052 UBERON:0004212 ! inheres in glomerular capillary +relationship: RO:0000052 UBERON:0004212 ! inheres in glomerular capillary [Term] id: OBA:VT0005326 name: podocyte morphology trait -def: "The morphology of a glomerular visceral epithelial cell." [AUTO:patterns/patterns/entity_attribute] -synonym: "morphology of glomerular visceral epithelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:1000844 ! glomerular visceral epithelial cell quality +def: "The morphology of a podocyte." [AUTO:patterns/patterns/entity_attribute] +synonym: "morphology of podocyte" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:1000844 ! podocyte quality is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000653 ! glomerular visceral epithelial cell +intersection_of: RO:0000052 CL:0000653 ! inheres in podocyte [Term] id: OBA:VT0005327 name: mesangial cell morphology trait def: "The morphology of a mesangial cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of mesangial cell" EXACT [AUTO:patterns/patterns/entity_attribute] -is_a: OBA:0003861 ! pericyte cell morphology +is_a: OBA:0003861 ! pericyte morphology is_a: OBA:1000663 ! mesangial cell quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000650 ! mesangial cell +intersection_of: RO:0000052 CL:0000650 ! inheres in mesangial cell [Term] id: OBA:VT0005328 @@ -185035,8 +286187,8 @@ def: "The morphology of a myocardium." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of myocardium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005084 ! heart layer morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002349 ! myocardium -relationship: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium +relationship: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:VT0005334 @@ -185045,8 +286197,8 @@ def: "The morphology of a fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000003 ! adipose morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003916 ! fat pad -relationship: inheres_in UBERON:0003916 ! fat pad +intersection_of: RO:0000052 UBERON:0003916 ! inheres in fat pad +relationship: RO:0000052 UBERON:0003916 ! inheres in fat pad [Term] id: OBA:VT0005335 @@ -185055,8 +286207,8 @@ def: "The morphology of a gonadal fat pad." [AUTO:patterns/patterns/entity_attri synonym: "morphology of gonadal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003428 ! gonadal fat pad -relationship: inheres_in UBERON:0003428 ! gonadal fat pad +intersection_of: RO:0000052 UBERON:0003428 ! inheres in gonadal fat pad +relationship: RO:0000052 UBERON:0003428 ! inheres in gonadal fat pad [Term] id: OBA:VT0005336 @@ -185065,8 +286217,8 @@ def: "The morphology of a inguinal fat pad." [AUTO:patterns/patterns/entity_attr synonym: "morphology of inguinal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010410 ! inguinal fat pad -relationship: inheres_in UBERON:0010410 ! inguinal fat pad +intersection_of: RO:0000052 UBERON:0010410 ! inheres in inguinal fat pad +relationship: RO:0000052 UBERON:0010410 ! inheres in inguinal fat pad [Term] id: OBA:VT0005337 @@ -185075,8 +286227,8 @@ def: "The morphology of a retroperitoneal fat pad." [AUTO:patterns/patterns/enti synonym: "morphology of retroperitoneal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000010 ! abdominal fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010411 ! retroperitoneal fat pad -relationship: inheres_in UBERON:0010411 ! retroperitoneal fat pad +intersection_of: RO:0000052 UBERON:0010411 ! inheres in retroperitoneal fat pad +relationship: RO:0000052 UBERON:0010411 ! inheres in retroperitoneal fat pad [Term] id: OBA:VT0005345 @@ -185103,8 +286255,8 @@ synonym: "morphology of patella" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002446 ! patella -relationship: inheres_in UBERON:0002446 ! patella +intersection_of: RO:0000052 UBERON:0002446 ! inheres in patella +relationship: RO:0000052 UBERON:0002446 ! inheres in patella [Term] id: OBA:VT0005354 @@ -185115,7 +286267,7 @@ is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000177 ! ilium quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001273 ! ilium +intersection_of: RO:0000052 UBERON:0001273 ! inheres in ilium [Term] id: OBA:VT0005355 @@ -185125,7 +286277,7 @@ synonym: "size of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000681 ! thyroid gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:VT0005358 @@ -185135,7 +286287,7 @@ synonym: "morphology of incisor tooth" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000578 ! incisor tooth quality is_a: OBA:VT0002100 ! tooth morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001098 ! incisor tooth +intersection_of: RO:0000052 UBERON:0001098 ! inheres in incisor tooth [Term] id: OBA:VT0005361 @@ -185145,7 +286297,7 @@ synonym: "size of pituitary gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000633 ! pituitary gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:VT0005362 @@ -185155,8 +286307,8 @@ synonym: "functionality of Langerhans cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0003704 ! dendritic cell functionality is_a: OBA:1000243 ! myeloid leukocyte quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000453 ! Langerhans cell -relationship: inheres_in CL:0000453 ! Langerhans cell +intersection_of: RO:0000052 CL:0000453 ! inheres in Langerhans cell +relationship: RO:0000052 CL:0000453 ! inheres in Langerhans cell [Term] id: OBA:VT0005369 @@ -185165,8 +286317,8 @@ def: "The quality when measured in musculature of body." [AUTO:patterns/patterns synonym: "musculature of body quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000383 ! musculature of body -relationship: inheres_in UBERON:0000383 ! musculature of body +intersection_of: RO:0000052 UBERON:0000383 ! inheres in musculature of body +relationship: RO:0000052 UBERON:0000383 ! inheres in musculature of body [Term] id: OBA:VT0005372 @@ -185175,8 +286327,8 @@ def: "The quality of a life cycle." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of life cycle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000104 ! life cycle -relationship: inheres_in UBERON:0000104 ! life cycle +intersection_of: RO:0000052 UBERON:0000104 ! inheres in life cycle +relationship: RO:0000052 UBERON:0000104 ! inheres in life cycle [Term] id: OBA:VT0005380 @@ -185185,8 +286337,8 @@ def: "The quality of a embryo development." [AUTO:patterns/patterns/entity_attri synonym: "quality of embryo development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009790 ! embryo development -relationship: inheres_in GO:0009790 ! embryo development +intersection_of: RO:0000052 GO:0009790 ! inheres in embryo development +relationship: RO:0000052 GO:0009790 ! inheres in embryo development [Term] id: OBA:VT0005382 @@ -185195,8 +286347,8 @@ def: "The quality of a head." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000033 ! head -relationship: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head +relationship: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0005388 @@ -185205,8 +286357,8 @@ def: "The quality when measured in respiratory system." [AUTO:patterns/patterns/ synonym: "respiratory system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001004 ! respiratory system -relationship: inheres_in UBERON:0001004 ! respiratory system +intersection_of: RO:0000052 UBERON:0001004 ! inheres in respiratory system +relationship: RO:0000052 UBERON:0001004 ! inheres in respiratory system [Term] id: OBA:VT0005389 @@ -185215,8 +286367,8 @@ def: "The quality when measured in reproductive system." [AUTO:patterns/patterns synonym: "reproductive system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000990 ! reproductive system -relationship: inheres_in UBERON:0000990 ! reproductive system +intersection_of: RO:0000052 UBERON:0000990 ! inheres in reproductive system +relationship: RO:0000052 UBERON:0000990 ! inheres in reproductive system [Term] id: OBA:VT0005394 @@ -185225,8 +286377,8 @@ def: "The quality when measured in olfactory system." [AUTO:patterns/patterns/at synonym: "olfactory system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005725 ! olfactory system -relationship: inheres_in UBERON:0005725 ! olfactory system +intersection_of: RO:0000052 UBERON:0005725 ! inheres in olfactory system +relationship: RO:0000052 UBERON:0005725 ! inheres in olfactory system [Term] id: OBA:VT0005402 @@ -185235,8 +286387,8 @@ def: "The quality of a action potential." [AUTO:patterns/patterns/entity_attribu synonym: "quality of action potential" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PATO:0001463 ! action potential -relationship: inheres_in PATO:0001463 ! action potential +intersection_of: RO:0000052 PATO:0001463 ! inheres in action potential +relationship: RO:0000052 PATO:0001463 ! inheres in action potential [Term] id: OBA:VT0005404 @@ -185245,8 +286397,8 @@ def: "The morphology of a axon." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of axon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015108 ! neurite morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030424 ! axon -relationship: inheres_in GO:0030424 ! axon +intersection_of: RO:0000052 GO:0030424 ! inheres in axon +relationship: RO:0000052 GO:0030424 ! inheres in axon [Term] id: OBA:VT0005406 @@ -185256,7 +286408,7 @@ synonym: "size of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000266 ! heart morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:VT0005410 @@ -185265,8 +286417,8 @@ def: "The quality of a fertilization." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fertilization" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009566 ! fertilization -relationship: inheres_in GO:0009566 ! fertilization +intersection_of: RO:0000052 GO:0009566 ! inheres in fertilization +relationship: RO:0000052 GO:0009566 ! inheres in fertilization [Term] id: OBA:VT0005416 @@ -185290,7 +286442,7 @@ synonym: "functionality of somatic nervous system" EXACT [AUTO:patterns/patterns is_a: OBA:1000193 ! somatic nervous system quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000012 ! somatic nervous system +intersection_of: RO:0000052 UBERON:0000012 ! inheres in somatic nervous system [Term] id: OBA:VT0005425 @@ -185301,8 +286453,8 @@ is_a: OBA:0005899 ! myeloid cell amount is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0000217 ! leukocyte quantity intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000235 ! macrophage -relationship: inheres_in CL:0000235 ! macrophage +intersection_of: RO:0000052 CL:0000235 ! inheres in macrophage +relationship: RO:0000052 CL:0000235 ! inheres in macrophage [Term] id: OBA:VT0005431 @@ -185311,8 +286463,8 @@ def: "The has number of of a oocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "has number of of oocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002209 ! germ cell quanitity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000023 ! oocyte -relationship: inheres_in CL:0000023 ! oocyte +intersection_of: RO:0000052 CL:0000023 ! inheres in oocyte +relationship: RO:0000052 CL:0000023 ! inheres in oocyte [Term] id: OBA:VT0005432 @@ -185321,8 +286473,8 @@ def: "The morphology of a pro-B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000826 ! pro-B cell -relationship: inheres_in CL:0000826 ! pro-B cell +intersection_of: RO:0000052 CL:0000826 ! inheres in pro-B cell +relationship: RO:0000052 CL:0000826 ! inheres in pro-B cell [Term] id: OBA:VT0005437 @@ -185332,8 +286484,8 @@ synonym: "amount of glycogen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100004 ! chemical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:28087 ! glycogen -relationship: inheres_in CHEBI:28087 ! glycogen +intersection_of: RO:0000052 CHEBI:28087 ! inheres in glycogen +relationship: RO:0000052 CHEBI:28087 ! inheres in glycogen [Term] id: OBA:VT0005443 @@ -185342,8 +286494,8 @@ def: "The quality of a ethanol metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of ethanol metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015089 ! alcohol metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006067 ! ethanol metabolic process -relationship: inheres_in GO:0006067 ! ethanol metabolic process +intersection_of: RO:0000052 GO:0006067 ! inheres in ethanol metabolic process +relationship: RO:0000052 GO:0006067 ! inheres in ethanol metabolic process [Term] id: OBA:VT0005444 @@ -185352,8 +286504,8 @@ def: "The quality of a retinol metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of retinol metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015089 ! alcohol metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0042572 ! retinol metabolic process -relationship: inheres_in GO:0042572 ! retinol metabolic process +intersection_of: RO:0000052 GO:0042572 ! inheres in retinol metabolic process +relationship: RO:0000052 GO:0042572 ! inheres in retinol metabolic process [Term] id: OBA:VT0005445 @@ -185362,8 +286514,8 @@ def: "The quality of a neurotransmitter secretion." [AUTO:patterns/patterns/enti synonym: "quality of neurotransmitter secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007269 ! neurotransmitter secretion -relationship: inheres_in GO:0007269 ! neurotransmitter secretion +intersection_of: RO:0000052 GO:0007269 ! inheres in neurotransmitter secretion +relationship: RO:0000052 GO:0007269 ! inheres in neurotransmitter secretion [Term] id: OBA:VT0005450 @@ -185373,7 +286525,7 @@ synonym: "energy of metabolic process" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0002121 ! metabolism trait is_a: PATO:0001021 ! energy intersection_of: PATO:0001021 ! energy -intersection_of: inheres_in GO:0008152 ! metabolic process +intersection_of: RO:0000052 GO:0008152 ! inheres in metabolic process [Term] id: OBA:VT0005452 @@ -185383,8 +286535,8 @@ synonym: "amount of adipose tissue" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0001013 ! adipose tissue -relationship: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue +relationship: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:VT0005461 @@ -185394,8 +286546,8 @@ synonym: "morphology of dendritic cell" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0004321 ! professional antigen presenting cell morphology is_a: OBA:0004338 ! mononuclear cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000451 ! dendritic cell -relationship: inheres_in CL:0000451 ! dendritic cell +intersection_of: RO:0000052 CL:0000451 ! inheres in dendritic cell +relationship: RO:0000052 CL:0000451 ! inheres in dendritic cell [Term] id: OBA:VT0005464 @@ -185405,8 +286557,8 @@ synonym: "functionality of platelet" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003194 ! cell functionality is_a: OBA:1000866 ! blood cell quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000233 ! platelet -relationship: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet +relationship: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:VT0005475 @@ -185433,8 +286585,8 @@ synonym: "amount of bronchial epithelial cell" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002328 ! bronchial epithelial cell -relationship: inheres_in CL:0002328 ! bronchial epithelial cell +intersection_of: RO:0000052 CL:0002328 ! inheres in bronchial epithelial cell +relationship: RO:0000052 CL:0002328 ! inheres in bronchial epithelial cell [Term] id: OBA:VT0005490 @@ -185444,8 +286596,8 @@ synonym: "has number of of club cell" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000158 ! club cell -relationship: inheres_in CL:0000158 ! club cell +intersection_of: RO:0000052 CL:0000158 ! inheres in club cell +relationship: RO:0000052 CL:0000158 ! inheres in club cell [Term] id: OBA:VT0005499 @@ -185455,8 +286607,8 @@ synonym: "morphology of chemosensory organ" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000005 ! chemosensory organ -relationship: inheres_in UBERON:0000005 ! chemosensory organ +intersection_of: RO:0000052 UBERON:0000005 ! inheres in chemosensory organ +relationship: RO:0000052 UBERON:0000005 ! inheres in chemosensory organ [Term] id: OBA:VT0005500 @@ -185466,7 +286618,7 @@ synonym: "morphology of gustatory system" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0015065 ! gustatory system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001033 ! gustatory system +intersection_of: RO:0000052 UBERON:0001033 ! inheres in gustatory system [Term] id: OBA:VT0005501 @@ -185476,8 +286628,8 @@ synonym: "functionality of zone of skin" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:VT0005502 @@ -185487,7 +286639,7 @@ synonym: "functionality of renal system" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT1000777 ! urinary system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001008 ! renal system +intersection_of: RO:0000052 UBERON:0001008 ! inheres in renal system [Term] id: OBA:VT0005503 @@ -185496,8 +286648,8 @@ def: "The morphology of a tendon." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of tendon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000043 ! tendon -relationship: inheres_in UBERON:0000043 ! tendon +intersection_of: RO:0000052 UBERON:0000043 ! inheres in tendon +relationship: RO:0000052 UBERON:0000043 ! inheres in tendon [Term] id: OBA:VT0005504 @@ -185507,8 +286659,8 @@ synonym: "morphology of ligament" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000211 ! ligament -relationship: inheres_in UBERON:0000211 ! ligament +intersection_of: RO:0000052 UBERON:0000211 ! inheres in ligament +relationship: RO:0000052 UBERON:0000211 ! inheres in ligament [Term] id: OBA:VT0005521 @@ -185525,7 +286677,7 @@ synonym: "temperature of multicellular organism" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0010454 ! organism trait is_a: PATO:0000146 ! temperature intersection_of: PATO:0000146 ! temperature -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0005537 @@ -185535,7 +286687,7 @@ synonym: "morphology of midbrain cerebral aqueduct" EXACT [AUTO:patterns/pattern is_a: OBA:1000808 ! midbrain cerebral aqueduct quality is_a: OBA:VT0000822 ! brain ventricle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002289 ! midbrain cerebral aqueduct +intersection_of: RO:0000052 UBERON:0002289 ! inheres in midbrain cerebral aqueduct [Term] id: OBA:VT0005543 @@ -185545,7 +286697,7 @@ synonym: "thickness of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002104 ! cornea size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:VT0005545 @@ -185554,8 +286706,8 @@ def: "The quality of a lens development in camera-type eye." [AUTO:patterns/patt synonym: "quality of lens development in camera-type eye" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002088 ! lens development in camera-type eye -relationship: inheres_in GO:0002088 ! lens development in camera-type eye +intersection_of: RO:0000052 GO:0002088 ! inheres in lens development in camera-type eye +relationship: RO:0000052 GO:0002088 ! inheres in lens development in camera-type eye [Term] id: OBA:VT0005547 @@ -185564,8 +286716,8 @@ def: "The morphology of a Mueller cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of Mueller cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003648 ! radial glial cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000636 ! Mueller cell -relationship: inheres_in CL:0000636 ! Mueller cell +intersection_of: RO:0000052 CL:0000636 ! inheres in Mueller cell +relationship: RO:0000052 CL:0000636 ! inheres in Mueller cell [Term] id: OBA:VT0005584 @@ -185574,8 +286726,8 @@ def: "The quality of a catalytic activity." [AUTO:patterns/patterns/entity_attri synonym: "quality of catalytic activity" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0003824 ! catalytic activity -relationship: inheres_in GO:0003824 ! catalytic activity +intersection_of: RO:0000052 GO:0003824 ! inheres in catalytic activity +relationship: RO:0000052 GO:0003824 ! inheres in catalytic activity [Term] id: OBA:VT0005592 @@ -185584,8 +286736,8 @@ def: "The morphology of a blood vessel smooth muscle." [AUTO:patterns/patterns/e synonym: "morphology of blood vessel smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000767 ! smooth muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004237 ! blood vessel smooth muscle -relationship: inheres_in UBERON:0004237 ! blood vessel smooth muscle +intersection_of: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle +relationship: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle [Term] id: OBA:VT0005593 @@ -185594,8 +286746,8 @@ def: "The contractility of a blood vessel smooth muscle." [AUTO:patterns/pattern synonym: "contractility of blood vessel smooth muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000740 ! smooth muscle contractility trait intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0004237 ! blood vessel smooth muscle -relationship: inheres_in UBERON:0004237 ! blood vessel smooth muscle +intersection_of: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle +relationship: RO:0000052 UBERON:0004237 ! inheres in blood vessel smooth muscle [Term] id: OBA:VT0005603 @@ -185605,7 +286757,7 @@ synonym: "size of neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:VT0005609 @@ -185623,7 +286775,7 @@ synonym: "morphology of meninx" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000435 ! meninx quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002360 ! meninx +intersection_of: RO:0000052 UBERON:0002360 ! inheres in meninx [Term] id: OBA:VT0005629 @@ -185633,8 +286785,8 @@ synonym: "mass of lung" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002048 ! lung -relationship: inheres_in UBERON:0002048 ! lung +intersection_of: RO:0000052 UBERON:0002048 ! inheres in lung +relationship: RO:0000052 UBERON:0002048 ! inheres in lung [Term] id: OBA:VT0005645 @@ -185644,8 +286796,8 @@ synonym: "functionality of hypothalamus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001898 ! hypothalamus -relationship: inheres_in UBERON:0001898 ! hypothalamus +intersection_of: RO:0000052 UBERON:0001898 ! inheres in hypothalamus +relationship: RO:0000052 UBERON:0001898 ! inheres in hypothalamus [Term] id: OBA:VT0005646 @@ -185655,7 +286807,7 @@ synonym: "functionality of pituitary gland" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0005872 ! neuroendocrine gland functionality is_a: OBA:1000518 ! pituitary gland quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:VT0005647 @@ -185664,8 +286816,8 @@ def: "The functionality of a reproductive gland." [AUTO:patterns/patterns/entity synonym: "functionality of reproductive gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002164 ! gland physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0003937 ! reproductive gland -relationship: inheres_in UBERON:0003937 ! reproductive gland +intersection_of: RO:0000052 UBERON:0003937 ! inheres in reproductive gland +relationship: RO:0000052 UBERON:0003937 ! inheres in reproductive gland [Term] id: OBA:VT0005650 @@ -185674,8 +286826,8 @@ def: "The morphology of a limb bud." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of limb bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004347 ! limb bud -relationship: inheres_in UBERON:0004347 ! limb bud +intersection_of: RO:0000052 UBERON:0004347 ! inheres in limb bud +relationship: RO:0000052 UBERON:0004347 ! inheres in limb bud [Term] id: OBA:VT0005651 @@ -185685,8 +286837,8 @@ synonym: "morphology of indifferent gonad" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009117 ! indifferent gonad -relationship: inheres_in UBERON:0009117 ! indifferent gonad +intersection_of: RO:0000052 UBERON:0009117 ! inheres in indifferent gonad +relationship: RO:0000052 UBERON:0009117 ! inheres in indifferent gonad [Term] id: OBA:VT0005657 @@ -185695,8 +286847,8 @@ def: "The morphology of a neural plate." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of neural plate" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003075 ! neural plate -relationship: inheres_in UBERON:0003075 ! neural plate +intersection_of: RO:0000052 UBERON:0003075 ! inheres in neural plate +relationship: RO:0000052 UBERON:0003075 ! inheres in neural plate [Term] id: OBA:VT0005660 @@ -185729,7 +286881,7 @@ synonym: "size of gall bladder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005812 ! abdominal viscera size is_a: OBA:VT0005084 ! gall bladder morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002110 ! gall bladder +intersection_of: RO:0000052 UBERON:0002110 ! inheres in gall bladder [Term] id: OBA:VT0006000 @@ -185739,7 +286891,7 @@ synonym: "morphology of corneal epithelium" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000266 ! corneal epithelium quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001772 ! corneal epithelium +intersection_of: RO:0000052 UBERON:0001772 ! inheres in corneal epithelium [Term] id: OBA:VT0006004 @@ -185748,8 +286900,8 @@ def: "The morphology of a interneuron." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of interneuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000099 ! interneuron -relationship: inheres_in CL:0000099 ! interneuron +intersection_of: RO:0000052 CL:0000099 ! inheres in interneuron +relationship: RO:0000052 CL:0000099 ! inheres in interneuron [Term] id: OBA:VT0006005 @@ -185759,8 +286911,8 @@ synonym: "has number of of interneuron" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000099 ! interneuron -relationship: inheres_in CL:0000099 ! interneuron +intersection_of: RO:0000052 CL:0000099 ! inheres in interneuron +relationship: RO:0000052 CL:0000099 ! inheres in interneuron [Term] id: OBA:VT0006006 @@ -185770,8 +286922,8 @@ synonym: "has number of of sensory neuron" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000101 ! sensory neuron -relationship: inheres_in CL:0000101 ! sensory neuron +intersection_of: RO:0000052 CL:0000101 ! inheres in sensory neuron +relationship: RO:0000052 CL:0000101 ! inheres in sensory neuron [Term] id: OBA:VT0006007 @@ -185781,8 +286933,8 @@ synonym: "morphology of basal ganglion" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002420 ! basal ganglion -relationship: inheres_in UBERON:0002420 ! basal ganglion +intersection_of: RO:0000052 UBERON:0002420 ! inheres in basal ganglion +relationship: RO:0000052 UBERON:0002420 ! inheres in basal ganglion [Term] id: OBA:VT0006008 @@ -185791,8 +286943,8 @@ def: "The quality of a neurogenesis." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of neurogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0022008 ! neurogenesis -relationship: inheres_in GO:0022008 ! neurogenesis +intersection_of: RO:0000052 GO:0022008 ! inheres in neurogenesis +relationship: RO:0000052 GO:0022008 ! inheres in neurogenesis [Term] id: OBA:VT0006009 @@ -185801,8 +286953,8 @@ def: "The quality of a neuron migration." [AUTO:patterns/patterns/entity_attribu synonym: "quality of neuron migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001764 ! neuron migration -relationship: inheres_in GO:0001764 ! neuron migration +intersection_of: RO:0000052 GO:0001764 ! inheres in neuron migration +relationship: RO:0000052 GO:0001764 ! inheres in neuron migration [Term] id: OBA:VT0006011 @@ -185812,8 +286964,8 @@ synonym: "morphology of endolymphatic duct" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001860 ! endolymphatic duct -relationship: inheres_in UBERON:0001860 ! endolymphatic duct +intersection_of: RO:0000052 UBERON:0001860 ! inheres in endolymphatic duct +relationship: RO:0000052 UBERON:0001860 ! inheres in endolymphatic duct [Term] id: OBA:VT0006014 @@ -185823,8 +286975,8 @@ synonym: "size of endolymphatic sac" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000172 ! tube size is_a: OBA:0003432 ! inner ear epithelium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002223 ! endolymphatic sac -relationship: inheres_in UBERON:0002223 ! endolymphatic sac +intersection_of: RO:0000052 UBERON:0002223 ! inheres in endolymphatic sac +relationship: RO:0000052 UBERON:0002223 ! inheres in endolymphatic sac [Term] id: OBA:VT0006018 @@ -185834,8 +286986,8 @@ synonym: "morphology of tympanic membrane" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002364 ! tympanic membrane -relationship: inheres_in UBERON:0002364 ! tympanic membrane +intersection_of: RO:0000052 UBERON:0002364 ! inheres in tympanic membrane +relationship: RO:0000052 UBERON:0002364 ! inheres in tympanic membrane [Term] id: OBA:VT0006019 @@ -185845,7 +286997,7 @@ synonym: "size of tympanic membrane" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006018 ! tympanic membrane morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002364 ! tympanic membrane +intersection_of: RO:0000052 UBERON:0002364 ! inheres in tympanic membrane [Term] id: OBA:VT0006020 @@ -185855,7 +287007,7 @@ synonym: "size of tympanic ring" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000138 ! bone element size is_a: OBA:VT0000030 ! tympanic ring morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002218 ! tympanic ring +intersection_of: RO:0000052 UBERON:0002218 ! inheres in tympanic ring [Term] id: OBA:VT0006021 @@ -185865,8 +287017,8 @@ synonym: "morphology of vestibular membrane of cochlear duct" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002281 ! vestibular membrane of cochlear duct -relationship: inheres_in UBERON:0002281 ! vestibular membrane of cochlear duct +intersection_of: RO:0000052 UBERON:0002281 ! inheres in vestibular membrane of cochlear duct +relationship: RO:0000052 UBERON:0002281 ! inheres in vestibular membrane of cochlear duct [Term] id: OBA:VT0006025 @@ -185876,7 +287028,7 @@ synonym: "size of vestibular membrane of cochlear duct" EXACT [AUTO:patterns/pat is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006021 ! Reissner membrane morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002281 ! vestibular membrane of cochlear duct +intersection_of: RO:0000052 UBERON:0002281 ! inheres in vestibular membrane of cochlear duct [Term] id: OBA:VT0006026 @@ -185886,7 +287038,7 @@ synonym: "size of terminal bronchiole" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000168 ! tracheal tube size is_a: OBA:VT0002268 ! terminal bronchiole morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002187 ! terminal bronchiole +intersection_of: RO:0000052 UBERON:0002187 ! inheres in terminal bronchiole [Term] id: OBA:VT0006029 @@ -185895,8 +287047,8 @@ def: "The morphology of a sclerotome." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of sclerotome" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004221 ! mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003089 ! sclerotome -relationship: inheres_in UBERON:0003089 ! sclerotome +intersection_of: RO:0000052 UBERON:0003089 ! inheres in sclerotome +relationship: RO:0000052 UBERON:0003089 ! inheres in sclerotome [Term] id: OBA:VT0006030 @@ -185905,8 +287057,8 @@ def: "The morphology of a ear vesicle." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of ear vesicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003051 ! ear vesicle -relationship: inheres_in UBERON:0003051 ! ear vesicle +intersection_of: RO:0000052 UBERON:0003051 ! inheres in ear vesicle +relationship: RO:0000052 UBERON:0003051 ! inheres in ear vesicle [Term] id: OBA:VT0006031 @@ -185915,8 +287067,8 @@ def: "The morphology of a pharyngeal pouch." [AUTO:patterns/patterns/entity_attr synonym: "morphology of pharyngeal pouch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004117 ! pharyngeal pouch -relationship: inheres_in UBERON:0004117 ! pharyngeal pouch +intersection_of: RO:0000052 UBERON:0004117 ! inheres in pharyngeal pouch +relationship: RO:0000052 UBERON:0004117 ! inheres in pharyngeal pouch [Term] id: OBA:VT0006032 @@ -185925,8 +287077,8 @@ def: "The morphology of a ureteric bud." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of ureteric bud" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004105 ! kidney epithelium morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000084 ! ureteric bud -relationship: inheres_in UBERON:0000084 ! ureteric bud +intersection_of: RO:0000052 UBERON:0000084 ! inheres in ureteric bud +relationship: RO:0000052 UBERON:0000084 ! inheres in ureteric bud [Term] id: OBA:VT0006033 @@ -185936,7 +287088,7 @@ synonym: "morphology of external acoustic meatus" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000704 ! external acoustic meatus quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001352 ! external acoustic meatus +intersection_of: RO:0000052 UBERON:0001352 ! inheres in external acoustic meatus [Term] id: OBA:VT0006034 @@ -185952,8 +287104,8 @@ def: "The morphology of a blood vessel endothelial cell." [AUTO:patterns/pattern synonym: "morphology of blood vessel endothelial cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004177 ! endothelial cell of vascular tree morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000071 ! blood vessel endothelial cell -relationship: inheres_in CL:0000071 ! blood vessel endothelial cell +intersection_of: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell +relationship: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell [Term] id: OBA:VT0006057 @@ -185963,8 +287115,8 @@ synonym: "has number of of blood vessel endothelial cell" EXACT [AUTO:patterns/p is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000071 ! blood vessel endothelial cell -relationship: inheres_in CL:0000071 ! blood vessel endothelial cell +intersection_of: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell +relationship: RO:0000052 CL:0000071 ! inheres in blood vessel endothelial cell [Term] id: OBA:VT0006061 @@ -185974,7 +287126,7 @@ synonym: "symmetry of cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0003105 ! heart atrium morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0002081 ! cardiac atrium +intersection_of: RO:0000052 UBERON:0002081 ! inheres in cardiac atrium [Term] id: OBA:VT0006062 @@ -185984,7 +287136,7 @@ synonym: "morphology of vena cava" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000524 ! vena cava quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004087 ! vena cava +intersection_of: RO:0000052 UBERON:0004087 ! inheres in vena cava [Term] id: OBA:VT0006063 @@ -185993,8 +287145,8 @@ def: "The morphology of a posterior vena cava." [AUTO:patterns/patterns/entity_a synonym: "morphology of posterior vena cava" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006062 ! vena cava morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001072 ! posterior vena cava -relationship: inheres_in UBERON:0001072 ! posterior vena cava +intersection_of: RO:0000052 UBERON:0001072 ! inheres in posterior vena cava +relationship: RO:0000052 UBERON:0001072 ! inheres in posterior vena cava [Term] id: OBA:VT0006064 @@ -186003,8 +287155,8 @@ def: "The morphology of a anterior vena cava." [AUTO:patterns/patterns/entity_at synonym: "morphology of anterior vena cava" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006062 ! vena cava morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001585 ! anterior vena cava -relationship: inheres_in UBERON:0001585 ! anterior vena cava +intersection_of: RO:0000052 UBERON:0001585 ! inheres in anterior vena cava +relationship: RO:0000052 UBERON:0001585 ! inheres in anterior vena cava [Term] id: OBA:VT0006065 @@ -186014,8 +287166,8 @@ synonym: "position of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000948 ! heart -relationship: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart +relationship: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:VT0006068 @@ -186024,8 +287176,8 @@ def: "The morphology of a retina horizontal cell." [AUTO:patterns/patterns/entit synonym: "morphology of retina horizontal cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006004 ! interneuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000745 ! retina horizontal cell -relationship: inheres_in CL:0000745 ! retina horizontal cell +intersection_of: RO:0000052 CL:0000745 ! inheres in retina horizontal cell +relationship: RO:0000052 CL:0000745 ! inheres in retina horizontal cell [Term] id: OBA:VT0006069 @@ -186034,8 +287186,8 @@ def: "The morphology of a retinal neural layer." [AUTO:patterns/patterns/entity_ synonym: "morphology of retinal neural layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003727 ! retinal layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003902 ! retinal neural layer -relationship: inheres_in UBERON:0003902 ! retinal neural layer +intersection_of: RO:0000052 UBERON:0003902 ! inheres in retinal neural layer +relationship: RO:0000052 UBERON:0003902 ! inheres in retinal neural layer [Term] id: OBA:VT0006076 @@ -186052,8 +287204,8 @@ synonym: "morphology of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002030 ! nipple -relationship: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple +relationship: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT0006083 @@ -186063,7 +287215,7 @@ synonym: "morphology of blood vessel elastic tissue" EXACT [AUTO:patterns/patter is_a: OBA:1000798 ! blood vessel elastic tissue quality is_a: OBA:VT0001248 ! connective tissue morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003614 ! blood vessel elastic tissue +intersection_of: RO:0000052 UBERON:0003614 ! inheres in blood vessel elastic tissue [Term] id: OBA:VT0006084 @@ -186081,8 +287233,8 @@ def: "The morphology of a saccule of membranous labyrinth." [AUTO:patterns/patte synonym: "morphology of saccule of membranous labyrinth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004425 ! otolith organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001854 ! saccule of membranous labyrinth -relationship: inheres_in UBERON:0001854 ! saccule of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001854 ! inheres in saccule of membranous labyrinth +relationship: RO:0000052 UBERON:0001854 ! inheres in saccule of membranous labyrinth [Term] id: OBA:VT0006090 @@ -186091,8 +287243,8 @@ def: "The morphology of a utricle of membranous labyrinth." [AUTO:patterns/patte synonym: "morphology of utricle of membranous labyrinth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004425 ! otolith organ morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001853 ! utricle of membranous labyrinth -relationship: inheres_in UBERON:0001853 ! utricle of membranous labyrinth +intersection_of: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth +relationship: RO:0000052 UBERON:0001853 ! inheres in utricle of membranous labyrinth [Term] id: OBA:VT0006091 @@ -186101,8 +287253,8 @@ def: "The morphology of a olfactory epithelium." [AUTO:patterns/patterns/entity_ synonym: "morphology of olfactory epithelium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002238 ! nasal mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001997 ! olfactory epithelium -relationship: inheres_in UBERON:0001997 ! olfactory epithelium +intersection_of: RO:0000052 UBERON:0001997 ! inheres in olfactory epithelium +relationship: RO:0000052 UBERON:0001997 ! inheres in olfactory epithelium [Term] id: OBA:VT0006092 @@ -186111,8 +287263,8 @@ def: "The morphology of a olfactory receptor cell." [AUTO:patterns/patterns/enti synonym: "morphology of olfactory receptor cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003589 ! chemoreceptor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000207 ! olfactory receptor cell -relationship: inheres_in CL:0000207 ! olfactory receptor cell +intersection_of: RO:0000052 CL:0000207 ! inheres in olfactory receptor cell +relationship: RO:0000052 CL:0000207 ! inheres in olfactory receptor cell [Term] id: OBA:VT0006099 @@ -186122,8 +287274,8 @@ synonym: "thickness of cortical layer II" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0000791 ! cerebral cortex layer morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0005391 ! cortical layer II -relationship: inheres_in UBERON:0005391 ! cortical layer II +intersection_of: RO:0000052 UBERON:0005391 ! inheres in cortical layer II +relationship: RO:0000052 UBERON:0005391 ! inheres in cortical layer II [Term] id: OBA:VT0006100 @@ -186133,8 +287285,8 @@ synonym: "morphology of midbrain tegmentum" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001943 ! midbrain tegmentum -relationship: inheres_in UBERON:0001943 ! midbrain tegmentum +intersection_of: RO:0000052 UBERON:0001943 ! inheres in midbrain tegmentum +relationship: RO:0000052 UBERON:0001943 ! inheres in midbrain tegmentum [Term] id: OBA:VT0006102 @@ -186144,7 +287296,7 @@ synonym: "size of midbrain tegmentum" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006100 ! tegmentum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001943 ! midbrain tegmentum +intersection_of: RO:0000052 UBERON:0001943 ! inheres in midbrain tegmentum [Term] id: OBA:VT0006103 @@ -186153,8 +287305,8 @@ def: "The morphology of a roof plate of midbrain." [AUTO:patterns/patterns/entit synonym: "morphology of roof plate of midbrain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003689 ! embryonic tissue morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003299 ! roof plate of midbrain -relationship: inheres_in UBERON:0003299 ! roof plate of midbrain +intersection_of: RO:0000052 UBERON:0003299 ! inheres in roof plate of midbrain +relationship: RO:0000052 UBERON:0003299 ! inheres in roof plate of midbrain [Term] id: OBA:VT0006104 @@ -186164,8 +287316,8 @@ synonym: "morphology of midbrain tectum" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002314 ! midbrain tectum -relationship: inheres_in UBERON:0002314 ! midbrain tectum +intersection_of: RO:0000052 UBERON:0002314 ! inheres in midbrain tectum +relationship: RO:0000052 UBERON:0002314 ! inheres in midbrain tectum [Term] id: OBA:VT0006105 @@ -186175,7 +287327,7 @@ synonym: "size of midbrain tectum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006104 ! tectum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002314 ! midbrain tectum +intersection_of: RO:0000052 UBERON:0002314 ! inheres in midbrain tectum [Term] id: OBA:VT0006107 @@ -186185,8 +287337,8 @@ synonym: "morphology of atrioventricular canal" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002087 ! atrioventricular canal -relationship: inheres_in UBERON:0002087 ! atrioventricular canal +intersection_of: RO:0000052 UBERON:0002087 ! inheres in atrioventricular canal +relationship: RO:0000052 UBERON:0002087 ! inheres in atrioventricular canal [Term] id: OBA:VT0006108 @@ -186195,8 +287347,8 @@ def: "The quality of a hindbrain development." [AUTO:patterns/patterns/entity_at synonym: "quality of hindbrain development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030902 ! hindbrain development -relationship: inheres_in GO:0030902 ! hindbrain development +intersection_of: RO:0000052 GO:0030902 ! inheres in hindbrain development +relationship: RO:0000052 GO:0030902 ! inheres in hindbrain development [Term] id: OBA:VT0006113 @@ -186206,7 +287358,7 @@ synonym: "morphology of cardiac septum" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000251 ! cardiac septum quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002099 ! cardiac septum +intersection_of: RO:0000052 UBERON:0002099 ! inheres in cardiac septum [Term] id: OBA:VT0006127 @@ -186216,8 +287368,8 @@ synonym: "orientation of great vessel of heart" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0013768 ! great vessel of heart -relationship: inheres_in UBERON:0013768 ! great vessel of heart +intersection_of: RO:0000052 UBERON:0013768 ! inheres in great vessel of heart +relationship: RO:0000052 UBERON:0013768 ! inheres in great vessel of heart [Term] id: OBA:VT0006151 @@ -186227,7 +287379,7 @@ synonym: "curvature of cornea" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003344 ! cornea shape is_a: PATO:0001591 ! curvature intersection_of: PATO:0001591 ! curvature -intersection_of: inheres_in UBERON:0000964 ! cornea +intersection_of: RO:0000052 UBERON:0000964 ! inheres in cornea [Term] id: OBA:VT0006162 @@ -186237,7 +287389,7 @@ synonym: "thickness of eyelid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003431 ! eyelid size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001711 ! eyelid +intersection_of: RO:0000052 UBERON:0001711 ! inheres in eyelid [Term] id: OBA:VT0006168 @@ -186246,8 +287398,8 @@ def: "The morphology of a epicanthal fold." [AUTO:patterns/patterns/entity_attri synonym: "morphology of epicanthal fold" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002096 ! skin morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013766 ! epicanthal fold -relationship: inheres_in UBERON:0013766 ! epicanthal fold +intersection_of: RO:0000052 UBERON:0013766 ! inheres in epicanthal fold +relationship: RO:0000052 UBERON:0013766 ! inheres in epicanthal fold [Term] id: OBA:VT0006173 @@ -186257,8 +287409,8 @@ synonym: "morphology of myeloid dendritic cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:0004339 ! myeloid leukocyte morphology is_a: OBA:VT0005461 ! dendritic cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000782 ! myeloid dendritic cell -relationship: inheres_in CL:0000782 ! myeloid dendritic cell +intersection_of: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell +relationship: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell [Term] id: OBA:VT0006175 @@ -186268,7 +287420,7 @@ synonym: "size of optic choroid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005098 ! choroid morphology trait is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001776 ! optic choroid +intersection_of: RO:0000052 UBERON:0001776 ! inheres in optic choroid [Term] id: OBA:VT0006192 @@ -186278,8 +287430,8 @@ synonym: "morphology of conjunctival vein" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000301 ! head blood vessel quality is_a: OBA:VT0002725 ! vein morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010367 ! conjunctival vein -relationship: inheres_in UBERON:0010367 ! conjunctival vein +intersection_of: RO:0000052 UBERON:0010367 ! inheres in conjunctival vein +relationship: RO:0000052 UBERON:0010367 ! inheres in conjunctival vein [Term] id: OBA:VT0006195 @@ -186289,7 +287441,7 @@ synonym: "orientation of eyeball of camera-type eye" EXACT [AUTO:patterns/patter is_a: OBA:0002106 ! eyeball of camera-type eye position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0010230 ! eyeball of camera-type eye +intersection_of: RO:0000052 UBERON:0010230 ! inheres in eyeball of camera-type eye [Term] id: OBA:VT0006210 @@ -186299,7 +287451,7 @@ synonym: "size of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005246 ! orbit morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:VT0006212 @@ -186309,7 +287461,7 @@ synonym: "width of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0006210 ! orbit size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:VT0006213 @@ -186319,7 +287471,7 @@ synonym: "depth of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0006210 ! orbit size trait is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:VT0006214 @@ -186329,7 +287481,7 @@ synonym: "symmetry of orbit of skull" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:VT0005246 ! orbit morphology trait is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001697 ! orbit of skull +intersection_of: RO:0000052 UBERON:0001697 ! inheres in orbit of skull [Term] id: OBA:VT0006215 @@ -186339,7 +287491,7 @@ synonym: "morphology of optic disc" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000929 ! optic disc quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001783 ! optic disc +intersection_of: RO:0000052 UBERON:0001783 ! inheres in optic disc [Term] id: OBA:VT0006216 @@ -186349,7 +287501,7 @@ synonym: "size of optic disc" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0006215 ! optic disc morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001783 ! optic disc +intersection_of: RO:0000052 UBERON:0001783 ! inheres in optic disc [Term] id: OBA:VT0006228 @@ -186359,7 +287511,7 @@ synonym: "size of iris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001322 ! iris morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001769 ! iris +intersection_of: RO:0000052 UBERON:0001769 ! inheres in iris [Term] id: OBA:VT0006235 @@ -186369,7 +287521,7 @@ synonym: "has number of of pupil" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000396 ! pupil quality is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:VT0006237 @@ -186379,7 +287531,7 @@ synonym: "morphology of choroidal blood vessel" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000661 ! choroidal blood vessel quality is_a: OBA:VT0001614 ! blood vessel morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002443 ! choroidal blood vessel +intersection_of: RO:0000052 UBERON:0002443 ! inheres in choroidal blood vessel [Term] id: OBA:VT0006241 @@ -186389,7 +287541,7 @@ synonym: "position of pupil" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000396 ! pupil quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0001771 ! pupil +intersection_of: RO:0000052 UBERON:0001771 ! inheres in pupil [Term] id: OBA:VT0006245 @@ -186399,7 +287551,7 @@ synonym: "position of lens of camera-type eye" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000227 ! lens of camera-type eye quality is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position -intersection_of: inheres_in UBERON:0000965 ! lens of camera-type eye +intersection_of: RO:0000052 UBERON:0000965 ! inheres in lens of camera-type eye [Term] id: OBA:VT0006250 @@ -186409,8 +287561,8 @@ synonym: "morphology of line of Schwalbe" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011918 ! line of Schwalbe -relationship: inheres_in UBERON:0011918 ! line of Schwalbe +intersection_of: RO:0000052 UBERON:0011918 ! inheres in line of Schwalbe +relationship: RO:0000052 UBERON:0011918 ! inheres in line of Schwalbe [Term] id: OBA:VT0006256 @@ -186420,8 +287572,8 @@ synonym: "morphology of gustatory papilla of tongue" EXACT [AUTO:patterns/patter is_a: OBA:1000878 ! papilla of tongue quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014389 ! gustatory papilla of tongue -relationship: inheres_in UBERON:0014389 ! gustatory papilla of tongue +intersection_of: RO:0000052 UBERON:0014389 ! inheres in gustatory papilla of tongue +relationship: RO:0000052 UBERON:0014389 ! inheres in gustatory papilla of tongue [Term] id: OBA:VT0006257 @@ -186431,7 +287583,7 @@ synonym: "morphology of fungiform papilla" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:1000911 ! fungiform papilla quality is_a: OBA:VT0006256 ! gustatory papillae morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002448 ! fungiform papilla +intersection_of: RO:0000052 UBERON:0002448 ! inheres in fungiform papilla [Term] id: OBA:VT0006258 @@ -186441,7 +287593,7 @@ synonym: "morphology of vallate papilla" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000801 ! vallate papilla quality is_a: OBA:VT0006256 ! gustatory papillae morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000396 ! vallate papilla +intersection_of: RO:0000052 UBERON:0000396 ! inheres in vallate papilla [Term] id: OBA:VT0006259 @@ -186451,7 +287603,7 @@ synonym: "morphology of foliate papilla" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000749 ! foliate papilla quality is_a: OBA:VT0006256 ! gustatory papillae morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002468 ! foliate papilla +intersection_of: RO:0000052 UBERON:0002468 ! inheres in foliate papilla [Term] id: OBA:VT0006260 @@ -186461,7 +287613,7 @@ synonym: "morphology of tongue taste bud" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000666 ! tongue taste bud quality is_a: OBA:VT0001002 ! taste bud morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014451 ! tongue taste bud +intersection_of: RO:0000052 UBERON:0014451 ! inheres in tongue taste bud [Term] id: OBA:VT0006274 @@ -186478,8 +287630,8 @@ synonym: "functionality of autonomic nervous system" EXACT [AUTO:patterns/patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002410 ! autonomic nervous system -relationship: inheres_in UBERON:0002410 ! autonomic nervous system +intersection_of: RO:0000052 UBERON:0002410 ! inheres in autonomic nervous system +relationship: RO:0000052 UBERON:0002410 ! inheres in autonomic nervous system [Term] id: OBA:VT0006277 @@ -186489,8 +287641,8 @@ synonym: "functionality of parasympathetic nervous system" EXACT [AUTO:patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000011 ! parasympathetic nervous system -relationship: inheres_in UBERON:0000011 ! parasympathetic nervous system +intersection_of: RO:0000052 UBERON:0000011 ! inheres in parasympathetic nervous system +relationship: RO:0000052 UBERON:0000011 ! inheres in parasympathetic nervous system [Term] id: OBA:VT0006279 @@ -186499,8 +287651,8 @@ def: "The quality of a limb development." [AUTO:patterns/patterns/entity_attribu synonym: "quality of limb development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015069 ! appendage development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060173 ! limb development -relationship: inheres_in GO:0060173 ! limb development +intersection_of: RO:0000052 GO:0060173 ! inheres in limb development +relationship: RO:0000052 GO:0060173 ! inheres in limb development [Term] id: OBA:VT0006282 @@ -186510,7 +287662,7 @@ synonym: "morphology of spinal cord dorsal column" EXACT [AUTO:patterns/patterns is_a: OBA:1000209 ! spinal cord dorsal column quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005373 ! spinal cord dorsal column +intersection_of: RO:0000052 UBERON:0005373 ! inheres in spinal cord dorsal column [Term] id: OBA:VT0006385 @@ -186519,8 +287671,8 @@ def: "The morphology of a memory T cell." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of memory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000813 ! memory T cell -relationship: inheres_in CL:0000813 ! memory T cell +intersection_of: RO:0000052 CL:0000813 ! inheres in memory T cell +relationship: RO:0000052 CL:0000813 ! inheres in memory T cell [Term] id: OBA:VT0006387 @@ -186530,7 +287682,7 @@ synonym: "has number of of T cell" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000418 ! T cell quality is_a: OBA:VT0000717 ! lymphocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000084 ! T cell +intersection_of: RO:0000052 CL:0000084 ! inheres in T cell [Term] id: OBA:VT0007000 @@ -186540,8 +287692,8 @@ synonym: "orientation of apex of heart" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002098 ! apex of heart -relationship: inheres_in UBERON:0002098 ! apex of heart +intersection_of: RO:0000052 UBERON:0002098 ! inheres in apex of heart +relationship: RO:0000052 UBERON:0002098 ! inheres in apex of heart [Term] id: OBA:VT0007001 @@ -186551,8 +287703,8 @@ synonym: "morphology of endocardial cushion" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0003689 ! embryonic tissue morphology is_a: OBA:0005373 ! cardiac mesenchyme morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002062 ! endocardial cushion -relationship: inheres_in UBERON:0002062 ! endocardial cushion +intersection_of: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion +relationship: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion [Term] id: OBA:VT0007002 @@ -186562,7 +287714,7 @@ synonym: "size of endocardial cushion" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0007001 ! endocardial cushion morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002062 ! endocardial cushion +intersection_of: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion [Term] id: OBA:VT0007003 @@ -186572,7 +287724,7 @@ synonym: "thickness of endocardial cushion" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0007002 ! endocardial cushion size trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0002062 ! endocardial cushion +intersection_of: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion [Term] id: OBA:VT0007010 @@ -186582,8 +287734,8 @@ synonym: "has number of of cardiac muscle cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000746 ! cardiac muscle cell -relationship: inheres_in CL:0000746 ! cardiac muscle cell +intersection_of: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell +relationship: RO:0000052 CL:0000746 ! inheres in cardiac muscle cell [Term] id: OBA:VT0007026 @@ -186593,8 +287745,8 @@ synonym: "mass of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium -relationship: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium +relationship: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:VT0007027 @@ -186604,8 +287756,8 @@ synonym: "mass of right cardiac atrium" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002078 ! right cardiac atrium -relationship: inheres_in UBERON:0002078 ! right cardiac atrium +intersection_of: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium +relationship: RO:0000052 UBERON:0002078 ! inheres in right cardiac atrium [Term] id: OBA:VT0007028 @@ -186615,8 +287767,8 @@ synonym: "mass of heart" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000948 ! heart -relationship: inheres_in UBERON:0000948 ! heart +intersection_of: RO:0000052 UBERON:0000948 ! inheres in heart +relationship: RO:0000052 UBERON:0000948 ! inheres in heart [Term] id: OBA:VT0007030 @@ -186626,7 +287778,7 @@ synonym: "volume of heart left ventricle" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0002753 ! left ventricle size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:VT0007031 @@ -186636,7 +287788,7 @@ synonym: "mass of heart left ventricle" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000229 ! heart left ventricle quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:VT0007032 @@ -186646,7 +287798,7 @@ synonym: "volume of heart right ventricle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0002754 ! right ventricle size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:VT0007033 @@ -186656,7 +287808,7 @@ synonym: "mass of heart right ventricle" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000280 ! heart right ventricle quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002080 ! heart right ventricle +intersection_of: RO:0000052 UBERON:0002080 ! inheres in heart right ventricle [Term] id: OBA:VT0007036 @@ -186666,8 +287818,8 @@ synonym: "orientation of pericardium" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002407 ! pericardium -relationship: inheres_in UBERON:0002407 ! pericardium +intersection_of: RO:0000052 UBERON:0002407 ! inheres in pericardium +relationship: RO:0000052 UBERON:0002407 ! inheres in pericardium [Term] id: OBA:VT0007038 @@ -186677,8 +287829,8 @@ synonym: "orientation of endocardial cushion" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002062 ! endocardial cushion -relationship: inheres_in UBERON:0002062 ! endocardial cushion +intersection_of: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion +relationship: RO:0000052 UBERON:0002062 ! inheres in endocardial cushion [Term] id: OBA:VT0007041 @@ -186688,8 +287840,8 @@ synonym: "orientation of heart tube" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0004141 ! heart tube -relationship: inheres_in UBERON:0004141 ! heart tube +intersection_of: RO:0000052 UBERON:0004141 ! inheres in heart tube +relationship: RO:0000052 UBERON:0004141 ! inheres in heart tube [Term] id: OBA:VT0007081 @@ -186699,7 +287851,7 @@ synonym: "morphology of interatrial septum" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000157 ! interatrial septum quality is_a: OBA:VT0006113 ! heart septum morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002085 ! interatrial septum +intersection_of: RO:0000052 UBERON:0002085 ! inheres in interatrial septum [Term] id: OBA:VT0007082 @@ -186709,7 +287861,7 @@ synonym: "morphology of interventricular septum" EXACT [AUTO:patterns/patterns/e is_a: OBA:1000639 ! interventricular septum quality is_a: OBA:VT0006113 ! heart septum morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002094 ! interventricular septum +intersection_of: RO:0000052 UBERON:0002094 ! inheres in interventricular septum [Term] id: OBA:VT0007090 @@ -186719,7 +287871,7 @@ synonym: "size of aorta" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000032 ! blood vessel size is_a: OBA:VT0000272 ! aorta morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000947 ! aorta +intersection_of: RO:0000052 UBERON:0000947 ! inheres in aorta [Term] id: OBA:VT0007091 @@ -186729,7 +287881,7 @@ synonym: "diameter of bulb of aorta" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0005483 ! bulb of aorta size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0010172 ! bulb of aorta +intersection_of: RO:0000052 UBERON:0010172 ! inheres in bulb of aorta [Term] id: OBA:VT0008037 @@ -186739,7 +287891,7 @@ synonym: "morphology of T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000418 ! T cell quality is_a: OBA:VT0002619 ! lymphocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000084 ! T cell +intersection_of: RO:0000052 CL:0000084 ! inheres in T cell [Term] id: OBA:VT0008043 @@ -186749,7 +287901,7 @@ synonym: "has number of of natural killer cell" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000559 ! natural killer cell quality is_a: OBA:VT0000717 ! lymphocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000623 ! natural killer cell +intersection_of: RO:0000052 CL:0000623 ! inheres in natural killer cell [Term] id: OBA:VT0008048 @@ -186758,8 +287910,8 @@ def: "The has number of of a memory T cell." [AUTO:patterns/patterns/entity_attr synonym: "has number of of memory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000813 ! memory T cell -relationship: inheres_in CL:0000813 ! memory T cell +intersection_of: RO:0000052 CL:0000813 ! inheres in memory T cell +relationship: RO:0000052 CL:0000813 ! inheres in memory T cell [Term] id: OBA:VT0008051 @@ -186768,8 +287920,8 @@ def: "The functionality of a memory T cell." [AUTO:patterns/patterns/entity_attr synonym: "functionality of memory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002444 ! T cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000813 ! memory T cell -relationship: inheres_in CL:0000813 ! memory T cell +intersection_of: RO:0000052 CL:0000813 ! inheres in memory T cell +relationship: RO:0000052 CL:0000813 ! inheres in memory T cell [Term] id: OBA:VT0008085 @@ -186778,8 +287930,8 @@ def: "The has number of of a T-helper 1 cell." [AUTO:patterns/patterns/entity_at synonym: "has number of of T-helper 1 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000545 ! T-helper 1 cell -relationship: inheres_in CL:0000545 ! T-helper 1 cell +intersection_of: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell +relationship: RO:0000052 CL:0000545 ! inheres in T-helper 1 cell [Term] id: OBA:VT0008088 @@ -186788,8 +287940,8 @@ def: "The quality of a T-helper 1 cell differentiation." [AUTO:patterns/patterns synonym: "quality of T-helper 1 cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002145 ! T cell development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045063 ! T-helper 1 cell differentiation -relationship: inheres_in GO:0045063 ! T-helper 1 cell differentiation +intersection_of: RO:0000052 GO:0045063 ! inheres in T-helper 1 cell differentiation +relationship: RO:0000052 GO:0045063 ! inheres in T-helper 1 cell differentiation [Term] id: OBA:VT0008089 @@ -186798,8 +287950,8 @@ def: "The has number of of a T-helper 2 cell." [AUTO:patterns/patterns/entity_at synonym: "has number of of T-helper 2 cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000546 ! T-helper 2 cell -relationship: inheres_in CL:0000546 ! T-helper 2 cell +intersection_of: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell +relationship: RO:0000052 CL:0000546 ! inheres in T-helper 2 cell [Term] id: OBA:VT0008092 @@ -186808,8 +287960,8 @@ def: "The quality of a T-helper 2 cell differentiation." [AUTO:patterns/patterns synonym: "quality of T-helper 2 cell differentiation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002145 ! T cell development trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045064 ! T-helper 2 cell differentiation -relationship: inheres_in GO:0045064 ! T-helper 2 cell differentiation +intersection_of: RO:0000052 GO:0045064 ! inheres in T-helper 2 cell differentiation +relationship: RO:0000052 GO:0045064 ! inheres in T-helper 2 cell differentiation [Term] id: OBA:VT0008093 @@ -186818,8 +287970,8 @@ def: "The has number of of a memory B cell." [AUTO:patterns/patterns/entity_attr synonym: "has number of of memory B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000787 ! memory B cell -relationship: inheres_in CL:0000787 ! memory B cell +intersection_of: RO:0000052 CL:0000787 ! inheres in memory B cell +relationship: RO:0000052 CL:0000787 ! inheres in memory B cell [Term] id: OBA:VT0008096 @@ -186828,8 +287980,8 @@ def: "The has number of of a plasma cell." [AUTO:patterns/patterns/entity_attrib synonym: "has number of of plasma cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000717 ! lymphocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000786 ! plasma cell -relationship: inheres_in CL:0000786 ! plasma cell +intersection_of: RO:0000052 CL:0000786 ! inheres in plasma cell +relationship: RO:0000052 CL:0000786 ! inheres in plasma cell [Term] id: OBA:VT0008114 @@ -186838,8 +287990,8 @@ def: "The morphology of a Kupffer cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of Kupffer cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000091 ! Kupffer cell -relationship: inheres_in CL:0000091 ! Kupffer cell +intersection_of: RO:0000052 CL:0000091 ! inheres in Kupffer cell +relationship: RO:0000052 CL:0000091 ! inheres in Kupffer cell [Term] id: OBA:VT0008115 @@ -186848,8 +288000,8 @@ def: "The dendritic of a cell maturation." [AUTO:patterns/patterns/entity_attrib synonym: "dendritic of cell maturation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002376 ! dendritic cell physiology trait intersection_of: PATO:0002045 ! dendritic -intersection_of: inheres_in GO:0048469 ! cell maturation -relationship: inheres_in GO:0048469 ! cell maturation +intersection_of: RO:0000052 GO:0048469 ! inheres in cell maturation +relationship: RO:0000052 GO:0048469 ! inheres in cell maturation [Term] id: OBA:VT0008117 @@ -186859,8 +288011,8 @@ synonym: "morphology of Langerhans cell" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004339 ! myeloid leukocyte morphology is_a: OBA:VT0005461 ! dendritic cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000453 ! Langerhans cell -relationship: inheres_in CL:0000453 ! Langerhans cell +intersection_of: RO:0000052 CL:0000453 ! inheres in Langerhans cell +relationship: RO:0000052 CL:0000453 ! inheres in Langerhans cell [Term] id: OBA:VT0008119 @@ -186870,8 +288022,8 @@ synonym: "has number of of Langerhans cell" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0008125 ! dendritic cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000453 ! Langerhans cell -relationship: inheres_in CL:0000453 ! Langerhans cell +intersection_of: RO:0000052 CL:0000453 ! inheres in Langerhans cell +relationship: RO:0000052 CL:0000453 ! inheres in Langerhans cell [Term] id: OBA:VT0008120 @@ -186881,8 +288033,8 @@ synonym: "has number of of myeloid dendritic cell" EXACT [AUTO:patterns/patterns is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0008125 ! dendritic cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000782 ! myeloid dendritic cell -relationship: inheres_in CL:0000782 ! myeloid dendritic cell +intersection_of: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell +relationship: RO:0000052 CL:0000782 ! inheres in myeloid dendritic cell [Term] id: OBA:VT0008123 @@ -186891,8 +288043,8 @@ def: "The has number of of a plasmacytoid dendritic cell." [AUTO:patterns/patter synonym: "has number of of plasmacytoid dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008125 ! dendritic cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000784 ! plasmacytoid dendritic cell -relationship: inheres_in CL:0000784 ! plasmacytoid dendritic cell +intersection_of: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell +relationship: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell [Term] id: OBA:VT0008125 @@ -186901,8 +288053,8 @@ def: "The has number of of a dendritic cell." [AUTO:patterns/patterns/entity_att synonym: "has number of of dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010191 ! immune system cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000451 ! dendritic cell -relationship: inheres_in CL:0000451 ! dendritic cell +intersection_of: RO:0000052 CL:0000451 ! inheres in dendritic cell +relationship: RO:0000052 CL:0000451 ! inheres in dendritic cell [Term] id: OBA:VT0008131 @@ -186912,8 +288064,8 @@ synonym: "has number of of Peyer's patch" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0001211 ! Peyer's patch -relationship: inheres_in UBERON:0001211 ! Peyer's patch +intersection_of: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch +relationship: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch [Term] id: OBA:VT0008134 @@ -186923,7 +288075,7 @@ synonym: "size of Peyer's patch" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003536 ! lymphoid tissue size is_a: OBA:VT0000696 ! Peyer's patch morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001211 ! Peyer's patch +intersection_of: RO:0000052 UBERON:0001211 ! inheres in Peyer's patch [Term] id: OBA:VT0008164 @@ -186932,8 +288084,8 @@ def: "The morphology of a B-1a B cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of B-1a B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004940 ! B-1 B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000820 ! B-1a B cell -relationship: inheres_in CL:0000820 ! B-1a B cell +intersection_of: RO:0000052 CL:0000820 ! inheres in B-1a B cell +relationship: RO:0000052 CL:0000820 ! inheres in B-1a B cell [Term] id: OBA:VT0008165 @@ -186942,8 +288094,8 @@ def: "The morphology of a B-1b B cell." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of B-1b B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004940 ! B-1 B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000821 ! B-1b B cell -relationship: inheres_in CL:0000821 ! B-1b B cell +intersection_of: RO:0000052 CL:0000821 ! inheres in B-1b B cell +relationship: RO:0000052 CL:0000821 ! inheres in B-1b B cell [Term] id: OBA:VT0008166 @@ -186952,8 +288104,8 @@ def: "The morphology of a B-2 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of B-2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000822 ! B-2 B cell -relationship: inheres_in CL:0000822 ! B-2 B cell +intersection_of: RO:0000052 CL:0000822 ! inheres in B-2 B cell +relationship: RO:0000052 CL:0000822 ! inheres in B-2 B cell [Term] id: OBA:VT0008167 @@ -186962,8 +288114,8 @@ def: "The has number of of a B-1a B cell." [AUTO:patterns/patterns/entity_attrib synonym: "has number of of B-1a B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004976 ! B-1 B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000820 ! B-1a B cell -relationship: inheres_in CL:0000820 ! B-1a B cell +intersection_of: RO:0000052 CL:0000820 ! inheres in B-1a B cell +relationship: RO:0000052 CL:0000820 ! inheres in B-1a B cell [Term] id: OBA:VT0008169 @@ -186972,8 +288124,8 @@ def: "The has number of of a B-1b B cell." [AUTO:patterns/patterns/entity_attrib synonym: "has number of of B-1b B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004976 ! B-1 B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000821 ! B-1b B cell -relationship: inheres_in CL:0000821 ! B-1b B cell +intersection_of: RO:0000052 CL:0000821 ! inheres in B-1b B cell +relationship: RO:0000052 CL:0000821 ! inheres in B-1b B cell [Term] id: OBA:VT0008171 @@ -186983,8 +288135,8 @@ synonym: "morphology of mature B cell" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0004321 ! professional antigen presenting cell morphology is_a: OBA:VT0004939 ! B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000785 ! mature B cell -relationship: inheres_in CL:0000785 ! mature B cell +intersection_of: RO:0000052 CL:0000785 ! inheres in mature B cell +relationship: RO:0000052 CL:0000785 ! inheres in mature B cell [Term] id: OBA:VT0008172 @@ -186993,8 +288145,8 @@ def: "The morphology of a follicular B cell." [AUTO:patterns/patterns/entity_att synonym: "morphology of follicular B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008166 ! B-2 B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000843 ! follicular B cell -relationship: inheres_in CL:0000843 ! follicular B cell +intersection_of: RO:0000052 CL:0000843 ! inheres in follicular B cell +relationship: RO:0000052 CL:0000843 ! inheres in follicular B cell [Term] id: OBA:VT0008174 @@ -187003,8 +288155,8 @@ def: "The has number of of a follicular B cell." [AUTO:patterns/patterns/entity_ synonym: "has number of of follicular B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008207 ! B-2 B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000843 ! follicular B cell -relationship: inheres_in CL:0000843 ! follicular B cell +intersection_of: RO:0000052 CL:0000843 ! inheres in follicular B cell +relationship: RO:0000052 CL:0000843 ! inheres in follicular B cell [Term] id: OBA:VT0008176 @@ -187013,8 +288165,8 @@ def: "The morphology of a germinal center B cell." [AUTO:patterns/patterns/entit synonym: "morphology of germinal center B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000844 ! germinal center B cell -relationship: inheres_in CL:0000844 ! germinal center B cell +intersection_of: RO:0000052 CL:0000844 ! inheres in germinal center B cell +relationship: RO:0000052 CL:0000844 ! inheres in germinal center B cell [Term] id: OBA:VT0008178 @@ -187023,8 +288175,8 @@ def: "The has number of of a germinal center B cell." [AUTO:patterns/patterns/en synonym: "has number of of germinal center B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000844 ! germinal center B cell -relationship: inheres_in CL:0000844 ! germinal center B cell +intersection_of: RO:0000052 CL:0000844 ! inheres in germinal center B cell +relationship: RO:0000052 CL:0000844 ! inheres in germinal center B cell [Term] id: OBA:VT0008180 @@ -187033,8 +288185,8 @@ def: "The morphology of a marginal zone B cell of spleen." [AUTO:patterns/patter synonym: "morphology of marginal zone B cell of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000845 ! marginal zone B cell of spleen -relationship: inheres_in CL:0000845 ! marginal zone B cell of spleen +intersection_of: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen +relationship: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen [Term] id: OBA:VT0008182 @@ -187043,8 +288195,8 @@ def: "The has number of of a marginal zone B cell of spleen." [AUTO:patterns/pat synonym: "has number of of marginal zone B cell of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000845 ! marginal zone B cell of spleen -relationship: inheres_in CL:0000845 ! marginal zone B cell of spleen +intersection_of: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen +relationship: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen [Term] id: OBA:VT0008184 @@ -187053,8 +288205,8 @@ def: "The morphology of a naive B cell." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of naive B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008171 ! mature B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000788 ! naive B cell -relationship: inheres_in CL:0000788 ! naive B cell +intersection_of: RO:0000052 CL:0000788 ! inheres in naive B cell +relationship: RO:0000052 CL:0000788 ! inheres in naive B cell [Term] id: OBA:VT0008185 @@ -187063,8 +288215,8 @@ def: "The has number of of a naive B cell." [AUTO:patterns/patterns/entity_attri synonym: "has number of of naive B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000788 ! naive B cell -relationship: inheres_in CL:0000788 ! naive B cell +intersection_of: RO:0000052 CL:0000788 ! inheres in naive B cell +relationship: RO:0000052 CL:0000788 ! inheres in naive B cell [Term] id: OBA:VT0008188 @@ -187073,8 +288225,8 @@ def: "The morphology of a transitional stage B cell." [AUTO:patterns/patterns/en synonym: "morphology of transitional stage B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004939 ! B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000818 ! transitional stage B cell -relationship: inheres_in CL:0000818 ! transitional stage B cell +intersection_of: RO:0000052 CL:0000818 ! inheres in transitional stage B cell +relationship: RO:0000052 CL:0000818 ! inheres in transitional stage B cell [Term] id: OBA:VT0008190 @@ -187083,8 +288235,8 @@ def: "The has number of of a transitional stage B cell." [AUTO:patterns/patterns synonym: "has number of of transitional stage B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000818 ! transitional stage B cell -relationship: inheres_in CL:0000818 ! transitional stage B cell +intersection_of: RO:0000052 CL:0000818 ! inheres in transitional stage B cell +relationship: RO:0000052 CL:0000818 ! inheres in transitional stage B cell [Term] id: OBA:VT0008191 @@ -187094,8 +288246,8 @@ synonym: "functionality of follicular B cell" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0003714 ! professional antigen presenting cell functionality is_a: OBA:VT0002459 ! B cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000843 ! follicular B cell -relationship: inheres_in CL:0000843 ! follicular B cell +intersection_of: RO:0000052 CL:0000843 ! inheres in follicular B cell +relationship: RO:0000052 CL:0000843 ! inheres in follicular B cell [Term] id: OBA:VT0008192 @@ -187105,8 +288257,8 @@ synonym: "functionality of germinal center B cell" EXACT [AUTO:patterns/patterns is_a: OBA:0003714 ! professional antigen presenting cell functionality is_a: OBA:VT0002459 ! B cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000844 ! germinal center B cell -relationship: inheres_in CL:0000844 ! germinal center B cell +intersection_of: RO:0000052 CL:0000844 ! inheres in germinal center B cell +relationship: RO:0000052 CL:0000844 ! inheres in germinal center B cell [Term] id: OBA:VT0008193 @@ -187116,8 +288268,8 @@ synonym: "functionality of marginal zone B cell of spleen" EXACT [AUTO:patterns/ is_a: OBA:0003714 ! professional antigen presenting cell functionality is_a: OBA:VT0002459 ! B cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000845 ! marginal zone B cell of spleen -relationship: inheres_in CL:0000845 ! marginal zone B cell of spleen +intersection_of: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen +relationship: RO:0000052 CL:0000845 ! inheres in marginal zone B cell of spleen [Term] id: OBA:VT0008194 @@ -187127,8 +288279,8 @@ synonym: "functionality of memory B cell" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003714 ! professional antigen presenting cell functionality is_a: OBA:VT0002459 ! B cell physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000787 ! memory B cell -relationship: inheres_in CL:0000787 ! memory B cell +intersection_of: RO:0000052 CL:0000787 ! inheres in memory B cell +relationship: RO:0000052 CL:0000787 ! inheres in memory B cell [Term] id: OBA:VT0008196 @@ -187137,8 +288289,8 @@ def: "The morphology of a follicular dendritic cell." [AUTO:patterns/patterns/en synonym: "morphology of follicular dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000442 ! follicular dendritic cell -relationship: inheres_in CL:0000442 ! follicular dendritic cell +intersection_of: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell +relationship: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell [Term] id: OBA:VT0008197 @@ -187147,8 +288299,8 @@ def: "The functionality of a follicular dendritic cell." [AUTO:patterns/patterns synonym: "functionality of follicular dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003194 ! cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000442 ! follicular dendritic cell -relationship: inheres_in CL:0000442 ! follicular dendritic cell +intersection_of: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell +relationship: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell [Term] id: OBA:VT0008200 @@ -187158,8 +288310,8 @@ synonym: "has number of of follicular dendritic cell" EXACT [AUTO:patterns/patte is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000442 ! follicular dendritic cell -relationship: inheres_in CL:0000442 ! follicular dendritic cell +intersection_of: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell +relationship: RO:0000052 CL:0000442 ! inheres in follicular dendritic cell [Term] id: OBA:VT0008207 @@ -187168,8 +288320,8 @@ def: "The has number of of a B-2 B cell." [AUTO:patterns/patterns/entity_attribu synonym: "has number of of B-2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000822 ! B-2 B cell -relationship: inheres_in CL:0000822 ! B-2 B cell +intersection_of: RO:0000052 CL:0000822 ! inheres in B-2 B cell +relationship: RO:0000052 CL:0000822 ! inheres in B-2 B cell [Term] id: OBA:VT0008208 @@ -187178,8 +288330,8 @@ def: "The has number of of a pro-B cell." [AUTO:patterns/patterns/entity_attribu synonym: "has number of of pro-B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000237 ! blood cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000826 ! pro-B cell -relationship: inheres_in CL:0000826 ! pro-B cell +intersection_of: RO:0000052 CL:0000826 ! inheres in pro-B cell +relationship: RO:0000052 CL:0000826 ! inheres in pro-B cell [Term] id: OBA:VT0008211 @@ -187189,7 +288341,7 @@ synonym: "decreased amount of mature B cell" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0004324 ! mature B cell amount is_a: PATO:0001997 ! decreased amount intersection_of: PATO:0001997 ! decreased amount -intersection_of: inheres_in CL:0000785 ! mature B cell +intersection_of: RO:0000052 CL:0000785 ! inheres in mature B cell [Term] id: OBA:VT0008215 @@ -187198,8 +288350,8 @@ def: "The has number of of a immature B cell." [AUTO:patterns/patterns/entity_at synonym: "has number of of immature B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002458 ! B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000816 ! immature B cell -relationship: inheres_in CL:0000816 ! immature B cell +intersection_of: RO:0000052 CL:0000816 ! inheres in immature B cell +relationship: RO:0000052 CL:0000816 ! inheres in immature B cell [Term] id: OBA:VT0008240 @@ -187208,8 +288360,8 @@ def: "The morphology of a splenic marginal zone macrophage." [AUTO:patterns/patt synonym: "morphology of splenic marginal zone macrophage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000872 ! splenic marginal zone macrophage -relationship: inheres_in CL:0000872 ! splenic marginal zone macrophage +intersection_of: RO:0000052 CL:0000872 ! inheres in splenic marginal zone macrophage +relationship: RO:0000052 CL:0000872 ! inheres in splenic marginal zone macrophage [Term] id: OBA:VT0008242 @@ -187218,8 +288370,8 @@ def: "The morphology of a perivascular macrophage." [AUTO:patterns/patterns/enti synonym: "morphology of perivascular macrophage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000881 ! perivascular macrophage -relationship: inheres_in CL:0000881 ! perivascular macrophage +intersection_of: RO:0000052 CL:0000881 ! inheres in perivascular macrophage +relationship: RO:0000052 CL:0000881 ! inheres in perivascular macrophage [Term] id: OBA:VT0008244 @@ -187228,8 +288380,8 @@ def: "The morphology of a peritoneal macrophage." [AUTO:patterns/patterns/entity synonym: "morphology of peritoneal macrophage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000581 ! peritoneal macrophage -relationship: inheres_in CL:0000581 ! peritoneal macrophage +intersection_of: RO:0000052 CL:0000581 ! inheres in peritoneal macrophage +relationship: RO:0000052 CL:0000581 ! inheres in peritoneal macrophage [Term] id: OBA:VT0008245 @@ -187238,8 +288390,8 @@ def: "The morphology of a alveolar macrophage." [AUTO:patterns/patterns/entity_a synonym: "morphology of alveolar macrophage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002446 ! macrophage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000583 ! alveolar macrophage -relationship: inheres_in CL:0000583 ! alveolar macrophage +intersection_of: RO:0000052 CL:0000583 ! inheres in alveolar macrophage +relationship: RO:0000052 CL:0000583 ! inheres in alveolar macrophage [Term] id: OBA:VT0008246 @@ -187249,8 +288401,8 @@ synonym: "morphology of leukocyte" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0005895 ! hematopoietic cell morphology is_a: OBA:VT0000716 ! immune system cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000738 ! leukocyte -relationship: inheres_in CL:0000738 ! leukocyte +intersection_of: RO:0000052 CL:0000738 ! inheres in leukocyte +relationship: RO:0000052 CL:0000738 ! inheres in leukocyte [Term] id: OBA:VT0008248 @@ -187260,8 +288412,8 @@ synonym: "morphology of mononuclear phagocyte" EXACT [AUTO:patterns/patterns/ent is_a: OBA:1000284 ! phagocyte (sensu Vertebrata) quality is_a: OBA:VT0008251 ! phagocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000113 ! mononuclear phagocyte -relationship: inheres_in CL:0000113 ! mononuclear phagocyte +intersection_of: RO:0000052 CL:0000113 ! inheres in mononuclear phagocyte +relationship: RO:0000052 CL:0000113 ! inheres in mononuclear phagocyte [Term] id: OBA:VT0008249 @@ -187270,8 +288422,8 @@ def: "The morphology of a common lymphoid progenitor." [AUTO:patterns/patterns/e synonym: "morphology of common lymphoid progenitor" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005908 ! hematopoietic precursor cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000051 ! common lymphoid progenitor -relationship: inheres_in CL:0000051 ! common lymphoid progenitor +intersection_of: RO:0000052 CL:0000051 ! inheres in common lymphoid progenitor +relationship: RO:0000052 CL:0000051 ! inheres in common lymphoid progenitor [Term] id: OBA:VT0008251 @@ -187280,8 +288432,8 @@ def: "The morphology of a phagocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of phagocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000234 ! phagocyte -relationship: inheres_in CL:0000234 ! phagocyte +intersection_of: RO:0000052 CL:0000234 ! inheres in phagocyte +relationship: RO:0000052 CL:0000234 ! inheres in phagocyte [Term] id: OBA:VT0008252 @@ -187291,8 +288443,8 @@ synonym: "morphology of multinucleated phagocyte" EXACT [AUTO:patterns/patterns/ is_a: OBA:1000284 ! phagocyte (sensu Vertebrata) quality is_a: OBA:VT0008251 ! phagocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000783 ! multinucleated phagocyte -relationship: inheres_in CL:0000783 ! multinucleated phagocyte +intersection_of: RO:0000052 CL:0000783 ! inheres in multinucleated phagocyte +relationship: RO:0000052 CL:0000783 ! inheres in multinucleated phagocyte [Term] id: OBA:VT0008343 @@ -187301,8 +288453,8 @@ def: "The morphology of a gamma-delta T cell." [AUTO:patterns/patterns/entity_at synonym: "morphology of gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000798 ! gamma-delta T cell -relationship: inheres_in CL:0000798 ! gamma-delta T cell +intersection_of: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell +relationship: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell [Term] id: OBA:VT0008344 @@ -187311,8 +288463,8 @@ def: "The morphology of a mature gamma-delta T cell." [AUTO:patterns/patterns/en synonym: "morphology of mature gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008343 ! gamma-delta T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000800 ! mature gamma-delta T cell -relationship: inheres_in CL:0000800 ! mature gamma-delta T cell +intersection_of: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell +relationship: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell [Term] id: OBA:VT0008345 @@ -187321,8 +288473,8 @@ def: "The has number of of a gamma-delta T cell." [AUTO:patterns/patterns/entity synonym: "has number of of gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006387 ! T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000798 ! gamma-delta T cell -relationship: inheres_in CL:0000798 ! gamma-delta T cell +intersection_of: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell +relationship: RO:0000052 CL:0000798 ! inheres in gamma-delta T cell [Term] id: OBA:VT0008349 @@ -187332,8 +288484,8 @@ synonym: "morphology of gamma-delta intraepithelial T cell" EXACT [AUTO:patterns is_a: OBA:VT0008344 ! mature gamma-delta T cell morphology trait is_a: OBA:VT0008894 ! intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell [Term] id: OBA:VT0008351 @@ -187342,8 +288494,8 @@ def: "The has number of of a gamma-delta intraepithelial T cell." [AUTO:patterns synonym: "has number of of gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008354 ! mature gamma-delta T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000801 ! gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000801 ! inheres in gamma-delta intraepithelial T cell [Term] id: OBA:VT0008354 @@ -187352,8 +288504,8 @@ def: "The has number of of a mature gamma-delta T cell." [AUTO:patterns/patterns synonym: "has number of of mature gamma-delta T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008345 ! gamma-delta T cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000800 ! mature gamma-delta T cell -relationship: inheres_in CL:0000800 ! mature gamma-delta T cell +intersection_of: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell +relationship: RO:0000052 CL:0000800 ! inheres in mature gamma-delta T cell [Term] id: OBA:VT0008357 @@ -187362,8 +288514,8 @@ def: "The morphology of a CD4-negative CD8-negative gamma-delta intraepithelial synonym: "morphology of CD4-negative CD8-negative gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008349 ! gamma-delta intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000803 ! CD4-negative CD8-negative gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000803 ! CD4-negative CD8-negative gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000803 ! inheres in CD4-negative CD8-negative gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000803 ! inheres in CD4-negative CD8-negative gamma-delta intraepithelial T cell [Term] id: OBA:VT0008361 @@ -187372,8 +288524,8 @@ def: "The morphology of a CD8-alpha alpha positive, gamma-delta intraepithelial synonym: "morphology of CD8-alpha alpha positive, gamma-delta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008349 ! gamma-delta intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell -relationship: inheres_in CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell +intersection_of: RO:0000052 CL:0000802 ! inheres in CD8-alpha alpha positive, gamma-delta intraepithelial T cell +relationship: RO:0000052 CL:0000802 ! inheres in CD8-alpha alpha positive, gamma-delta intraepithelial T cell [Term] id: OBA:VT0008397 @@ -187383,8 +288535,8 @@ synonym: "morphology of CD4-positive, CD25-positive, alpha-beta regulatory T cel is_a: OBA:0003713 ! CD4-positive, alpha-beta T cell morphology is_a: OBA:VT0004941 ! regulatory T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell -relationship: inheres_in CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell +intersection_of: RO:0000052 CL:0000792 ! inheres in CD4-positive, CD25-positive, alpha-beta regulatory T cell +relationship: RO:0000052 CL:0000792 ! inheres in CD4-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: OBA:VT0008398 @@ -187394,8 +288546,8 @@ synonym: "morphology of CD8-positive, alpha-beta regulatory T cell" EXACT [AUTO: is_a: OBA:0004117 ! CD8-positive, alpha-beta T cell morphology is_a: OBA:VT0004941 ! regulatory T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000795 ! CD8-positive, alpha-beta regulatory T cell -relationship: inheres_in CL:0000795 ! CD8-positive, alpha-beta regulatory T cell +intersection_of: RO:0000052 CL:0000795 ! inheres in CD8-positive, alpha-beta regulatory T cell +relationship: RO:0000052 CL:0000795 ! inheres in CD8-positive, alpha-beta regulatory T cell [Term] id: OBA:VT0008399 @@ -187405,8 +288557,8 @@ synonym: "morphology of alpha-beta intraepithelial T cell" EXACT [AUTO:patterns/ is_a: OBA:0005717 ! alpha-beta T cell morphology is_a: OBA:VT0008894 ! intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000797 ! alpha-beta intraepithelial T cell -relationship: inheres_in CL:0000797 ! alpha-beta intraepithelial T cell +intersection_of: RO:0000052 CL:0000797 ! inheres in alpha-beta intraepithelial T cell +relationship: RO:0000052 CL:0000797 ! inheres in alpha-beta intraepithelial T cell [Term] id: OBA:VT0008400 @@ -187416,8 +288568,8 @@ synonym: "morphology of CD4-positive, alpha-beta intraepithelial T cell" EXACT [ is_a: OBA:0003713 ! CD4-positive, alpha-beta T cell morphology is_a: OBA:VT0008399 ! alpha-beta intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell -relationship: inheres_in CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell +intersection_of: RO:0000052 CL:0000793 ! inheres in CD4-positive, alpha-beta intraepithelial T cell +relationship: RO:0000052 CL:0000793 ! inheres in CD4-positive, alpha-beta intraepithelial T cell [Term] id: OBA:VT0008401 @@ -187426,8 +288578,8 @@ def: "The morphology of a CD8-alpha-beta-positive, alpha-beta intraepithelial T synonym: "morphology of CD8-alpha-beta-positive, alpha-beta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008399 ! alpha-beta intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000796 ! CD8-alpha-beta-positive, alpha-beta intraepithelial T cell -relationship: inheres_in CL:0000796 ! CD8-alpha-beta-positive, alpha-beta intraepithelial T cell +intersection_of: RO:0000052 CL:0000796 ! inheres in CD8-alpha-beta-positive, alpha-beta intraepithelial T cell +relationship: RO:0000052 CL:0000796 ! inheres in CD8-alpha-beta-positive, alpha-beta intraepithelial T cell [Term] id: OBA:VT0008463 @@ -187436,8 +288588,8 @@ def: "The morphology of a peripheral lymph node." [AUTO:patterns/patterns/entity synonym: "morphology of peripheral lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003703 ! lymph node morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003968 ! peripheral lymph node -relationship: inheres_in UBERON:0003968 ! peripheral lymph node +intersection_of: RO:0000052 UBERON:0003968 ! inheres in peripheral lymph node +relationship: RO:0000052 UBERON:0003968 ! inheres in peripheral lymph node [Term] id: OBA:VT0008466 @@ -187447,7 +288599,7 @@ synonym: "size of mesenteric lymph node" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0005232 ! mesenteric lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002509 ! mesenteric lymph node +intersection_of: RO:0000052 UBERON:0002509 ! inheres in mesenteric lymph node [Term] id: OBA:VT0008470 @@ -187457,8 +288609,8 @@ synonym: "morphology of spleen lymphoid follicle" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001249 ! spleen lymphoid follicle -relationship: inheres_in UBERON:0001249 ! spleen lymphoid follicle +intersection_of: RO:0000052 UBERON:0001249 ! inheres in spleen lymphoid follicle +relationship: RO:0000052 UBERON:0001249 ! inheres in spleen lymphoid follicle [Term] id: OBA:VT0008471 @@ -187467,8 +288619,8 @@ def: "The morphology of a spleen primary B follicle." [AUTO:patterns/patterns/en synonym: "morphology of spleen primary B follicle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008470 ! splenic B cell follicle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004041 ! spleen primary B follicle -relationship: inheres_in UBERON:0004041 ! spleen primary B follicle +intersection_of: RO:0000052 UBERON:0004041 ! inheres in spleen primary B follicle +relationship: RO:0000052 UBERON:0004041 ! inheres in spleen primary B follicle [Term] id: OBA:VT0008472 @@ -187478,8 +288630,8 @@ synonym: "morphology of spleen secondary B follicle" EXACT [AUTO:patterns/patter is_a: OBA:VT0002346 ! lymph node secondary follicle morphology trait is_a: OBA:VT0008470 ! splenic B cell follicle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004042 ! spleen secondary B follicle -relationship: inheres_in UBERON:0004042 ! spleen secondary B follicle +intersection_of: RO:0000052 UBERON:0004042 ! inheres in spleen secondary B follicle +relationship: RO:0000052 UBERON:0004042 ! inheres in spleen secondary B follicle [Term] id: OBA:VT0008473 @@ -187489,8 +288641,8 @@ synonym: "morphology of spleen follicular dendritic cell network" EXACT [AUTO:pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010756 ! spleen follicular dendritic cell network -relationship: inheres_in UBERON:0010756 ! spleen follicular dendritic cell network +intersection_of: RO:0000052 UBERON:0010756 ! inheres in spleen follicular dendritic cell network +relationship: RO:0000052 UBERON:0010756 ! inheres in spleen follicular dendritic cell network [Term] id: OBA:VT0008482 @@ -187500,8 +288652,8 @@ synonym: "amount of spleen germinal center" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0005196 ! spleen germinal center -relationship: inheres_in UBERON:0005196 ! spleen germinal center +intersection_of: RO:0000052 UBERON:0005196 ! inheres in spleen germinal center +relationship: RO:0000052 UBERON:0005196 ! inheres in spleen germinal center [Term] id: OBA:VT0008484 @@ -187511,7 +288663,7 @@ synonym: "size of spleen germinal center" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0003536 ! lymphoid tissue size is_a: OBA:VT0002359 ! spleen germinal center morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0005196 ! spleen germinal center +intersection_of: RO:0000052 UBERON:0005196 ! inheres in spleen germinal center [Term] id: OBA:VT0008522 @@ -187521,8 +288673,8 @@ synonym: "morphology of lymph node germinal center" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0009039 ! lymph node germinal center -relationship: inheres_in UBERON:0009039 ! lymph node germinal center +intersection_of: RO:0000052 UBERON:0009039 ! inheres in lymph node germinal center +relationship: RO:0000052 UBERON:0009039 ! inheres in lymph node germinal center [Term] id: OBA:VT0008542 @@ -187532,7 +288684,7 @@ synonym: "size of cervical lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0002351 ! cervical lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002429 ! cervical lymph node +intersection_of: RO:0000052 UBERON:0002429 ! inheres in cervical lymph node [Term] id: OBA:VT0008557 @@ -187541,8 +288693,8 @@ def: "The quality of a interferon-alpha production." [AUTO:patterns/patterns/ent synonym: "quality of interferon-alpha production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032607 ! interferon-alpha production -relationship: inheres_in GO:0032607 ! interferon-alpha production +intersection_of: RO:0000052 GO:0032607 ! inheres in interferon-alpha production +relationship: RO:0000052 GO:0032607 ! inheres in interferon-alpha production [Term] id: OBA:VT0008558 @@ -187551,8 +288703,8 @@ def: "The quality of a interferon-beta production." [AUTO:patterns/patterns/enti synonym: "quality of interferon-beta production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032608 ! interferon-beta production -relationship: inheres_in GO:0032608 ! interferon-beta production +intersection_of: RO:0000052 GO:0032608 ! inheres in interferon-beta production +relationship: RO:0000052 GO:0032608 ! inheres in interferon-beta production [Term] id: OBA:VT0008559 @@ -187561,8 +288713,8 @@ def: "The quality of a interferon-gamma production." [AUTO:patterns/patterns/ent synonym: "quality of interferon-gamma production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032609 ! interferon-gamma production -relationship: inheres_in GO:0032609 ! interferon-gamma production +intersection_of: RO:0000052 GO:0032609 ! inheres in interferon-gamma production +relationship: RO:0000052 GO:0032609 ! inheres in interferon-gamma production [Term] id: OBA:VT0008589 @@ -187683,8 +288835,8 @@ def: "The quality of a interleukin-1 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-1 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032612 ! interleukin-1 production -relationship: inheres_in GO:0032612 ! interleukin-1 production +intersection_of: RO:0000052 GO:0032612 ! inheres in interleukin-1 production +relationship: RO:0000052 GO:0032612 ! inheres in interleukin-1 production [Term] id: OBA:VT0008653 @@ -187693,8 +288845,8 @@ def: "The quality of a interleukin-1 alpha production." [AUTO:patterns/patterns/ synonym: "quality of interleukin-1 alpha production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008650 ! interleukin-1 secretion trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032610 ! interleukin-1 alpha production -relationship: inheres_in GO:0032610 ! interleukin-1 alpha production +intersection_of: RO:0000052 GO:0032610 ! inheres in interleukin-1 alpha production +relationship: RO:0000052 GO:0032610 ! inheres in interleukin-1 alpha production [Term] id: OBA:VT0008656 @@ -187703,8 +288855,8 @@ def: "The quality of a interleukin-1 beta production." [AUTO:patterns/patterns/e synonym: "quality of interleukin-1 beta production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008650 ! interleukin-1 secretion trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032611 ! interleukin-1 beta production -relationship: inheres_in GO:0032611 ! interleukin-1 beta production +intersection_of: RO:0000052 GO:0032611 ! inheres in interleukin-1 beta production +relationship: RO:0000052 GO:0032611 ! inheres in interleukin-1 beta production [Term] id: OBA:VT0008659 @@ -187713,8 +288865,8 @@ def: "The quality of a interleukin-10 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-10 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032613 ! interleukin-10 production -relationship: inheres_in GO:0032613 ! interleukin-10 production +intersection_of: RO:0000052 GO:0032613 ! inheres in interleukin-10 production +relationship: RO:0000052 GO:0032613 ! inheres in interleukin-10 production [Term] id: OBA:VT0008662 @@ -187723,8 +288875,8 @@ def: "The quality of a interleukin-12 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-12 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032615 ! interleukin-12 production -relationship: inheres_in GO:0032615 ! interleukin-12 production +intersection_of: RO:0000052 GO:0032615 ! inheres in interleukin-12 production +relationship: RO:0000052 GO:0032615 ! inheres in interleukin-12 production [Term] id: OBA:VT0008671 @@ -187733,8 +288885,8 @@ def: "The quality of a interleukin-13 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-13 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032616 ! interleukin-13 production -relationship: inheres_in GO:0032616 ! interleukin-13 production +intersection_of: RO:0000052 GO:0032616 ! inheres in interleukin-13 production +relationship: RO:0000052 GO:0032616 ! inheres in interleukin-13 production [Term] id: OBA:VT0008674 @@ -187743,8 +288895,8 @@ def: "The quality of a interleukin-15 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-15 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032618 ! interleukin-15 production -relationship: inheres_in GO:0032618 ! interleukin-15 production +intersection_of: RO:0000052 GO:0032618 ! inheres in interleukin-15 production +relationship: RO:0000052 GO:0032618 ! inheres in interleukin-15 production [Term] id: OBA:VT0008677 @@ -187753,8 +288905,8 @@ def: "The quality of a interleukin-16 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-16 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032619 ! interleukin-16 production -relationship: inheres_in GO:0032619 ! interleukin-16 production +intersection_of: RO:0000052 GO:0032619 ! inheres in interleukin-16 production +relationship: RO:0000052 GO:0032619 ! inheres in interleukin-16 production [Term] id: OBA:VT0008680 @@ -187763,8 +288915,8 @@ def: "The quality of a interleukin-17 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-17 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032620 ! interleukin-17 production -relationship: inheres_in GO:0032620 ! interleukin-17 production +intersection_of: RO:0000052 GO:0032620 ! inheres in interleukin-17 production +relationship: RO:0000052 GO:0032620 ! inheres in interleukin-17 production [Term] id: OBA:VT0008683 @@ -187773,8 +288925,8 @@ def: "The quality of a interleukin-18 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-18 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032621 ! interleukin-18 production -relationship: inheres_in GO:0032621 ! interleukin-18 production +intersection_of: RO:0000052 GO:0032621 ! inheres in interleukin-18 production +relationship: RO:0000052 GO:0032621 ! inheres in interleukin-18 production [Term] id: OBA:VT0008686 @@ -187783,8 +288935,8 @@ def: "The quality of a interleukin-2 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-2 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032623 ! interleukin-2 production -relationship: inheres_in GO:0032623 ! interleukin-2 production +intersection_of: RO:0000052 GO:0032623 ! inheres in interleukin-2 production +relationship: RO:0000052 GO:0032623 ! inheres in interleukin-2 production [Term] id: OBA:VT0008689 @@ -187793,8 +288945,8 @@ def: "The quality of a interleukin-23 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-23 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032627 ! interleukin-23 production -relationship: inheres_in GO:0032627 ! interleukin-23 production +intersection_of: RO:0000052 GO:0032627 ! inheres in interleukin-23 production +relationship: RO:0000052 GO:0032627 ! inheres in interleukin-23 production [Term] id: OBA:VT0008695 @@ -187803,8 +288955,8 @@ def: "The quality of a interleukin-3 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-3 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032632 ! interleukin-3 production -relationship: inheres_in GO:0032632 ! interleukin-3 production +intersection_of: RO:0000052 GO:0032632 ! inheres in interleukin-3 production +relationship: RO:0000052 GO:0032632 ! inheres in interleukin-3 production [Term] id: OBA:VT0008698 @@ -187813,8 +288965,8 @@ def: "The quality of a interleukin-4 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-4 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032633 ! interleukin-4 production -relationship: inheres_in GO:0032633 ! interleukin-4 production +intersection_of: RO:0000052 GO:0032633 ! inheres in interleukin-4 production +relationship: RO:0000052 GO:0032633 ! inheres in interleukin-4 production [Term] id: OBA:VT0008701 @@ -187823,8 +288975,8 @@ def: "The quality of a interleukin-5 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-5 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032634 ! interleukin-5 production -relationship: inheres_in GO:0032634 ! interleukin-5 production +intersection_of: RO:0000052 GO:0032634 ! inheres in interleukin-5 production +relationship: RO:0000052 GO:0032634 ! inheres in interleukin-5 production [Term] id: OBA:VT0008704 @@ -187833,8 +288985,8 @@ def: "The quality of a interleukin-6 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-6 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032635 ! interleukin-6 production -relationship: inheres_in GO:0032635 ! interleukin-6 production +intersection_of: RO:0000052 GO:0032635 ! inheres in interleukin-6 production +relationship: RO:0000052 GO:0032635 ! inheres in interleukin-6 production [Term] id: OBA:VT0008707 @@ -187843,8 +288995,8 @@ def: "The quality of a interleukin-7 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-7 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032636 ! interleukin-7 production -relationship: inheres_in GO:0032636 ! interleukin-7 production +intersection_of: RO:0000052 GO:0032636 ! inheres in interleukin-7 production +relationship: RO:0000052 GO:0032636 ! inheres in interleukin-7 production [Term] id: OBA:VT0008710 @@ -187853,8 +289005,8 @@ def: "The quality of a interleukin-9 production." [AUTO:patterns/patterns/entity synonym: "quality of interleukin-9 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032638 ! interleukin-9 production -relationship: inheres_in GO:0032638 ! interleukin-9 production +intersection_of: RO:0000052 GO:0032638 ! inheres in interleukin-9 production +relationship: RO:0000052 GO:0032638 ! inheres in interleukin-9 production [Term] id: OBA:VT0008724 @@ -187863,8 +289015,8 @@ def: "The quality of a eosinophil migration." [AUTO:patterns/patterns/entity_att synonym: "quality of eosinophil migration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003156 ! leukocyte migration trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072677 ! eosinophil migration -relationship: inheres_in GO:0072677 ! eosinophil migration +intersection_of: RO:0000052 GO:0072677 ! inheres in eosinophil migration +relationship: RO:0000052 GO:0072677 ! inheres in eosinophil migration [Term] id: OBA:VT0008737 @@ -187873,8 +289025,8 @@ def: "The functionality of a spleen." [AUTO:patterns/patterns/entity_attribute] synonym: "functionality of spleen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003866 ! immune organ functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002106 ! spleen -relationship: inheres_in UBERON:0002106 ! spleen +intersection_of: RO:0000052 UBERON:0002106 ! inheres in spleen +relationship: RO:0000052 UBERON:0002106 ! inheres in spleen [Term] id: OBA:VT0008739 @@ -187890,8 +289042,8 @@ def: "The quality of a B cell anergy." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of B cell anergy" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005004 ! lymphocyte anergy trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002515 ! B cell anergy -relationship: inheres_in GO:0002515 ! B cell anergy +intersection_of: RO:0000052 GO:0002515 ! inheres in B cell anergy +relationship: RO:0000052 GO:0002515 ! inheres in B cell anergy [Term] id: OBA:VT0008745 @@ -187900,8 +289052,8 @@ def: "The quality of a central B cell anergy." [AUTO:patterns/patterns/entity_at synonym: "quality of central B cell anergy" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008744 ! B cell anergy trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002341 ! central B cell anergy -relationship: inheres_in GO:0002341 ! central B cell anergy +intersection_of: RO:0000052 GO:0002341 ! inheres in central B cell anergy +relationship: RO:0000052 GO:0002341 ! inheres in central B cell anergy [Term] id: OBA:VT0008746 @@ -187911,7 +289063,7 @@ synonym: "peripheral of B cell anergy" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0008744 ! B cell anergy trait is_a: PATO:0002107 ! peripheral intersection_of: PATO:0002107 ! peripheral -intersection_of: inheres_in GO:0002515 ! B cell anergy +intersection_of: RO:0000052 GO:0002515 ! inheres in B cell anergy [Term] id: OBA:VT0008747 @@ -187920,8 +289072,8 @@ def: "The quality of a T cell anergy." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of T cell anergy" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005004 ! lymphocyte anergy trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002870 ! T cell anergy -relationship: inheres_in GO:0002870 ! T cell anergy +intersection_of: RO:0000052 GO:0002870 ! inheres in T cell anergy +relationship: RO:0000052 GO:0002870 ! inheres in T cell anergy [Term] id: OBA:VT0008749 @@ -187931,7 +289083,7 @@ synonym: "peripheral of T cell anergy" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0004485 ! T cell anergy position is_a: PATO:0002107 ! peripheral intersection_of: PATO:0002107 ! peripheral -intersection_of: inheres_in GO:0002870 ! T cell anergy +intersection_of: RO:0000052 GO:0002870 ! inheres in T cell anergy [Term] id: OBA:VT0008752 @@ -187940,8 +289092,8 @@ def: "The amount of a tumor necrosis factor receptor binding." [AUTO:patterns/pa synonym: "amount of tumor necrosis factor receptor binding" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in GO:0005164 ! tumor necrosis factor receptor binding -relationship: inheres_in GO:0005164 ! tumor necrosis factor receptor binding +intersection_of: RO:0000052 GO:0005164 ! inheres in tumor necrosis factor receptor binding +relationship: RO:0000052 GO:0005164 ! inheres in tumor necrosis factor receptor binding [Term] id: OBA:VT0008754 @@ -187950,8 +289102,8 @@ def: "The quality of a T cell receptor V(D)J recombination." [AUTO:patterns/patt synonym: "quality of T cell receptor V(D)J recombination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033153 ! T cell receptor V(D)J recombination -relationship: inheres_in GO:0033153 ! T cell receptor V(D)J recombination +intersection_of: RO:0000052 GO:0033153 ! inheres in T cell receptor V(D)J recombination +relationship: RO:0000052 GO:0033153 ! inheres in T cell receptor V(D)J recombination [Term] id: OBA:VT0008755 @@ -187960,8 +289112,8 @@ def: "The quality of a immunoglobulin V(D)J recombination." [AUTO:patterns/patte synonym: "quality of immunoglobulin V(D)J recombination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0033152 ! immunoglobulin V(D)J recombination -relationship: inheres_in GO:0033152 ! immunoglobulin V(D)J recombination +intersection_of: RO:0000052 GO:0033152 ! inheres in immunoglobulin V(D)J recombination +relationship: RO:0000052 GO:0033152 ! inheres in immunoglobulin V(D)J recombination [Term] id: OBA:VT0008761 @@ -187970,8 +289122,8 @@ def: "The quality of a immunoglobulin light chain V-J recombination." [AUTO:patt synonym: "quality of immunoglobulin light chain V-J recombination" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008755 ! immunoglobulin V(D)J recombination trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0071708 ! immunoglobulin light chain V-J recombination -relationship: inheres_in GO:0071708 ! immunoglobulin light chain V-J recombination +intersection_of: RO:0000052 GO:0071708 ! inheres in immunoglobulin light chain V-J recombination +relationship: RO:0000052 GO:0071708 ! inheres in immunoglobulin light chain V-J recombination [Term] id: OBA:VT0008766 @@ -187980,8 +289132,8 @@ def: "The quality of a B cell receptor editing." [AUTO:patterns/patterns/entity_ synonym: "quality of B cell receptor editing" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002452 ! B cell receptor editing -relationship: inheres_in GO:0002452 ! B cell receptor editing +intersection_of: RO:0000052 GO:0002452 ! inheres in B cell receptor editing +relationship: RO:0000052 GO:0002452 ! inheres in B cell receptor editing [Term] id: OBA:VT0008769 @@ -187990,8 +289142,8 @@ def: "The functionality of a plasmacytoid dendritic cell." [AUTO:patterns/patter synonym: "functionality of plasmacytoid dendritic cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003704 ! dendritic cell functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000784 ! plasmacytoid dendritic cell -relationship: inheres_in CL:0000784 ! plasmacytoid dendritic cell +intersection_of: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell +relationship: RO:0000052 CL:0000784 ! inheres in plasmacytoid dendritic cell [Term] id: OBA:VT0008778 @@ -188000,8 +289152,8 @@ def: "The quality of a lymphangiogenesis." [AUTO:patterns/patterns/entity_attrib synonym: "quality of lymphangiogenesis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0001946 ! lymphangiogenesis -relationship: inheres_in GO:0001946 ! lymphangiogenesis +intersection_of: RO:0000052 GO:0001946 ! inheres in lymphangiogenesis +relationship: RO:0000052 GO:0001946 ! inheres in lymphangiogenesis [Term] id: OBA:VT0008894 @@ -188010,8 +289162,8 @@ def: "The morphology of a intraepithelial lymphocyte." [AUTO:patterns/patterns/e synonym: "morphology of intraepithelial lymphocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008037 ! T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002496 ! intraepithelial lymphocyte -relationship: inheres_in CL:0002496 ! intraepithelial lymphocyte +intersection_of: RO:0000052 CL:0002496 ! inheres in intraepithelial lymphocyte +relationship: RO:0000052 CL:0002496 ! inheres in intraepithelial lymphocyte [Term] id: OBA:VT0008895 @@ -188021,8 +289173,8 @@ synonym: "amount of CD4-positive, alpha-beta intraepithelial T cell" EXACT [AUTO is_a: OBA:0004294 ! CD4-positive, alpha-beta T cell amount is_a: OBA:0004525 ! intraepithelial lymphocyte amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell -relationship: inheres_in CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell +intersection_of: RO:0000052 CL:0000793 ! inheres in CD4-positive, alpha-beta intraepithelial T cell +relationship: RO:0000052 CL:0000793 ! inheres in CD4-positive, alpha-beta intraepithelial T cell [Term] id: OBA:VT0009056 @@ -188031,8 +289183,8 @@ def: "The quality of a interleukin-21 production." [AUTO:patterns/patterns/entit synonym: "quality of interleukin-21 production" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032625 ! interleukin-21 production -relationship: inheres_in GO:0032625 ! interleukin-21 production +intersection_of: RO:0000052 GO:0032625 ! inheres in interleukin-21 production +relationship: RO:0000052 GO:0032625 ! inheres in interleukin-21 production [Term] id: OBA:VT0009059 @@ -188048,8 +289200,8 @@ def: "The quality of a spleen development." [AUTO:patterns/patterns/entity_attri synonym: "quality of spleen development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048536 ! spleen development -relationship: inheres_in GO:0048536 ! spleen development +intersection_of: RO:0000052 GO:0048536 ! inheres in spleen development +relationship: RO:0000052 GO:0048536 ! inheres in spleen development [Term] id: OBA:VT0009539 @@ -188059,8 +289211,8 @@ synonym: "morphology of Hassall's corpuscle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003987 ! Hassall's corpuscle -relationship: inheres_in UBERON:0003987 ! Hassall's corpuscle +intersection_of: RO:0000052 UBERON:0003987 ! inheres in Hassall's corpuscle +relationship: RO:0000052 UBERON:0003987 ! inheres in Hassall's corpuscle [Term] id: OBA:VT0009543 @@ -188070,8 +289222,8 @@ synonym: "morphology of thymus corticomedullary boundary" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003988 ! thymus corticomedullary boundary -relationship: inheres_in UBERON:0003988 ! thymus corticomedullary boundary +intersection_of: RO:0000052 UBERON:0003988 ! inheres in thymus corticomedullary boundary +relationship: RO:0000052 UBERON:0003988 ! inheres in thymus corticomedullary boundary [Term] id: OBA:VT0009544 @@ -188081,8 +289233,8 @@ synonym: "morphology of thymus epithelium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003846 ! thymus epithelium -relationship: inheres_in UBERON:0003846 ! thymus epithelium +intersection_of: RO:0000052 UBERON:0003846 ! inheres in thymus epithelium +relationship: RO:0000052 UBERON:0003846 ! inheres in thymus epithelium [Term] id: OBA:VT0009623 @@ -188092,7 +289244,7 @@ synonym: "size of inguinal lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0002353 ! inguinal lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001542 ! inguinal lymph node +intersection_of: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node [Term] id: OBA:VT0009625 @@ -188101,8 +289253,8 @@ def: "The morphology of a abdominal lymph node." [AUTO:patterns/patterns/entity_ synonym: "morphology of abdominal lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003703 ! lymph node morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002507 ! abdominal lymph node -relationship: inheres_in UBERON:0002507 ! abdominal lymph node +intersection_of: RO:0000052 UBERON:0002507 ! inheres in abdominal lymph node +relationship: RO:0000052 UBERON:0002507 ! inheres in abdominal lymph node [Term] id: OBA:VT0009626 @@ -188111,8 +289263,8 @@ def: "The morphology of a celiac lymph node." [AUTO:patterns/patterns/entity_att synonym: "morphology of celiac lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0009625 ! abdominal lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002508 ! celiac lymph node -relationship: inheres_in UBERON:0002508 ! celiac lymph node +intersection_of: RO:0000052 UBERON:0002508 ! inheres in celiac lymph node +relationship: RO:0000052 UBERON:0002508 ! inheres in celiac lymph node [Term] id: OBA:VT0009627 @@ -188121,8 +289273,8 @@ def: "The morphology of a submandibular lymph node." [AUTO:patterns/patterns/ent synonym: "morphology of submandibular lymph node" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008463 ! peripheral lymph node morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002520 ! submandibular lymph node -relationship: inheres_in UBERON:0002520 ! submandibular lymph node +intersection_of: RO:0000052 UBERON:0002520 ! inheres in submandibular lymph node +relationship: RO:0000052 UBERON:0002520 ! inheres in submandibular lymph node [Term] id: OBA:VT0009629 @@ -188132,7 +289284,7 @@ synonym: "size of brachial lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0005231 ! brachial lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002525 ! brachial lymph node +intersection_of: RO:0000052 UBERON:0002525 ! inheres in brachial lymph node [Term] id: OBA:VT0009631 @@ -188142,7 +289294,7 @@ synonym: "size of axillary lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0002340 ! axillary lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001097 ! axillary lymph node +intersection_of: RO:0000052 UBERON:0001097 ! inheres in axillary lymph node [Term] id: OBA:VT0009635 @@ -188152,7 +289304,7 @@ synonym: "size of popliteal lymph node" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0002352 ! popliteal lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001543 ! popliteal lymph node +intersection_of: RO:0000052 UBERON:0001543 ! inheres in popliteal lymph node [Term] id: OBA:VT0009858 @@ -188161,8 +289313,8 @@ def: "The quality of a cellular extravasation." [AUTO:patterns/patterns/entity_a synonym: "quality of cellular extravasation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003156 ! leukocyte migration trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0045123 ! cellular extravasation -relationship: inheres_in GO:0045123 ! cellular extravasation +intersection_of: RO:0000052 GO:0045123 ! inheres in cellular extravasation +relationship: RO:0000052 GO:0045123 ! inheres in cellular extravasation [Term] id: OBA:VT0009919 @@ -188171,8 +289323,8 @@ def: "The morphology of a T1 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of T1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008188 ! transitional stage B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000958 ! T1 B cell -relationship: inheres_in CL:0000958 ! T1 B cell +intersection_of: RO:0000052 CL:0000958 ! inheres in T1 B cell +relationship: RO:0000052 CL:0000958 ! inheres in T1 B cell [Term] id: OBA:VT0009920 @@ -188181,8 +289333,8 @@ def: "The morphology of a T2 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of T2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008188 ! transitional stage B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000959 ! T2 B cell -relationship: inheres_in CL:0000959 ! T2 B cell +intersection_of: RO:0000052 CL:0000959 ! inheres in T2 B cell +relationship: RO:0000052 CL:0000959 ! inheres in T2 B cell [Term] id: OBA:VT0009921 @@ -188191,8 +289343,8 @@ def: "The morphology of a T3 B cell." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of T3 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008188 ! transitional stage B cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000960 ! T3 B cell -relationship: inheres_in CL:0000960 ! T3 B cell +intersection_of: RO:0000052 CL:0000960 ! inheres in T3 B cell +relationship: RO:0000052 CL:0000960 ! inheres in T3 B cell [Term] id: OBA:VT0009923 @@ -188201,8 +289353,8 @@ def: "The has number of of a T1 B cell." [AUTO:patterns/patterns/entity_attribut synonym: "has number of of T1 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008190 ! transitional stage B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000958 ! T1 B cell -relationship: inheres_in CL:0000958 ! T1 B cell +intersection_of: RO:0000052 CL:0000958 ! inheres in T1 B cell +relationship: RO:0000052 CL:0000958 ! inheres in T1 B cell [Term] id: OBA:VT0009926 @@ -188211,8 +289363,8 @@ def: "The has number of of a T2 B cell." [AUTO:patterns/patterns/entity_attribut synonym: "has number of of T2 B cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008190 ! transitional stage B cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000959 ! T2 B cell -relationship: inheres_in CL:0000959 ! T2 B cell +intersection_of: RO:0000052 CL:0000959 ! inheres in T2 B cell +relationship: RO:0000052 CL:0000959 ! inheres in T2 B cell [Term] id: OBA:VT0010002 @@ -188222,7 +289374,7 @@ synonym: "size of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000627 ! mammary gland morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0010003 @@ -188232,8 +289384,8 @@ synonym: "morphology of bone element" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:VT0010005 @@ -188242,8 +289394,8 @@ def: "The quality of a bone development." [AUTO:patterns/patterns/entity_attribu synonym: "quality of bone development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060348 ! bone development -relationship: inheres_in GO:0060348 ! bone development +intersection_of: RO:0000052 GO:0060348 ! inheres in bone development +relationship: RO:0000052 GO:0060348 ! inheres in bone development [Term] id: OBA:VT0010007 @@ -188252,8 +289404,8 @@ def: "The morphology of a cutaneous appendage." [AUTO:patterns/patterns/entity_a synonym: "morphology of cutaneous appendage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005148 ! integumentary adnexa morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000021 ! cutaneous appendage -relationship: inheres_in UBERON:0000021 ! cutaneous appendage +intersection_of: RO:0000052 UBERON:0000021 ! inheres in cutaneous appendage +relationship: RO:0000052 UBERON:0000021 ! inheres in cutaneous appendage [Term] id: OBA:VT0010009 @@ -188263,7 +289415,7 @@ synonym: "mass of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000621 ! femur quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0010010 @@ -188273,7 +289425,7 @@ synonym: "strength of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000621 ! femur quality is_a: OBA:VT0001542 ! bone strength trait intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0010012 @@ -188283,7 +289435,7 @@ synonym: "strength of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000326 ! humerus quality is_a: OBA:VT0001542 ! bone strength trait intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0010013 @@ -188293,7 +289445,7 @@ synonym: "mass of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000326 ! humerus quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0010014 @@ -188303,7 +289455,7 @@ synonym: "circumference of femur" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT1000369 ! femur size trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT0010015 @@ -188313,7 +289465,7 @@ synonym: "mass of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000340 ! tibia quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT0010018 @@ -188323,7 +289475,7 @@ synonym: "symmetry of mammary gland" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004835 ! mammary gland spatial pattern is_a: PATO:0000965 ! symmetry intersection_of: PATO:0000965 ! symmetry -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0010019 @@ -188333,8 +289485,8 @@ synonym: "mass of epididymis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001301 ! epididymis -relationship: inheres_in UBERON:0001301 ! epididymis +intersection_of: RO:0000052 UBERON:0001301 ! inheres in epididymis +relationship: RO:0000052 UBERON:0001301 ! inheres in epididymis [Term] id: OBA:VT0010020 @@ -188344,7 +289496,7 @@ synonym: "diameter of seminiferous tubule of testis" EXACT [AUTO:patterns/patter is_a: OBA:0000171 ! tube diameter is_a: OBA:VT0001153 ! seminiferous tubule size trait intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0001343 ! seminiferous tubule of testis +intersection_of: RO:0000052 UBERON:0001343 ! inheres in seminiferous tubule of testis [Term] id: OBA:VT0010022 @@ -188355,7 +289507,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003073 ! metacarpus morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0004453 ! metacarpus region +intersection_of: RO:0000052 UBERON:0004453 ! inheres in metacarpus region [Term] id: OBA:VT0010023 @@ -188365,7 +289517,7 @@ synonym: "length of forelimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000548 ! limb length is_a: OBA:VT0000550 ! forelimb morphology trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002102 ! forelimb +intersection_of: RO:0000052 UBERON:0002102 ! inheres in forelimb [Term] id: OBA:VT0010024 @@ -188375,7 +289527,7 @@ synonym: "length of hindlimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000548 ! limb length is_a: OBA:VT0000556 ! hindlimb morphology trait intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002103 ! hindlimb +intersection_of: RO:0000052 UBERON:0002103 ! inheres in hindlimb [Term] id: OBA:VT0010025 @@ -188406,7 +289558,7 @@ synonym: "height of udder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100035 ! udder size trait is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0013216 ! udder +intersection_of: RO:0000052 UBERON:0013216 ! inheres in udder [Term] id: OBA:VT0010032 @@ -188415,8 +289567,8 @@ def: "The quality of a http://purl.obolibrary.org/obo/GO_0090195." [AUTO:pattern synonym: "quality of http://purl.obolibrary.org/obo/GO_0090195" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0090195 -relationship: inheres_in GO:0090195 +intersection_of: RO:0000052 GO:0090195 ! inheres in +relationship: RO:0000052 GO:0090195 ! inheres in [Term] id: OBA:VT0010042 @@ -188426,8 +289578,8 @@ synonym: "morphology of sperm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003333 ! male germ cell morphology is_a: OBA:1000722 ! gamete quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000019 ! sperm -relationship: inheres_in CL:0000019 ! sperm +intersection_of: RO:0000052 CL:0000019 ! inheres in sperm +relationship: RO:0000052 CL:0000019 ! inheres in sperm [Term] id: OBA:VT0010043 @@ -188437,7 +289589,7 @@ synonym: "functionality of ovarian follicle" EXACT [AUTO:patterns/patterns/entit is_a: OBA:1000927 ! ovarian follicle quality is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001305 ! ovarian follicle +intersection_of: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle [Term] id: OBA:VT0010046 @@ -188446,8 +289598,8 @@ def: "The amount of a fatty acid." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of fatty acid" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001547 ! lipid amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:35366 ! fatty acid -relationship: inheres_in CHEBI:35366 ! fatty acid +intersection_of: RO:0000052 CHEBI:35366 ! inheres in fatty acid +relationship: RO:0000052 CHEBI:35366 ! inheres in fatty acid [Term] id: OBA:VT0010047 @@ -188456,8 +289608,8 @@ def: "The functionality of a tendon." [AUTO:patterns/patterns/entity_attribute] synonym: "functionality of tendon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010064 ! connective tissue physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000043 ! tendon -relationship: inheres_in UBERON:0000043 ! tendon +intersection_of: RO:0000052 UBERON:0000043 ! inheres in tendon +relationship: RO:0000052 UBERON:0000043 ! inheres in tendon [Term] id: OBA:VT0010048 @@ -188482,8 +289634,8 @@ def: "The morphology of a brown fat cell." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of brown fat cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004128 ! adipocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000449 ! brown fat cell -relationship: inheres_in CL:0000449 ! brown fat cell +intersection_of: RO:0000052 CL:0000449 ! inheres in brown fat cell +relationship: RO:0000052 CL:0000449 ! inheres in brown fat cell [Term] id: OBA:VT0010064 @@ -188493,7 +289645,7 @@ synonym: "functionality of connective tissue" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002384 ! connective tissue +intersection_of: RO:0000052 UBERON:0002384 ! inheres in connective tissue [Term] id: OBA:VT0010065 @@ -188502,8 +289654,8 @@ def: "The quality of a connective tissue development." [AUTO:patterns/patterns/e synonym: "quality of connective tissue development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0061448 ! connective tissue development -relationship: inheres_in GO:0061448 ! connective tissue development +intersection_of: RO:0000052 GO:0061448 ! inheres in connective tissue development +relationship: RO:0000052 GO:0061448 ! inheres in connective tissue development [Term] id: OBA:VT0010066 @@ -188512,8 +289664,8 @@ def: "The morphology of a loop of Henle." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of loop of Henle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001288 ! loop of Henle -relationship: inheres_in UBERON:0001288 ! loop of Henle +intersection_of: RO:0000052 UBERON:0001288 ! inheres in loop of Henle +relationship: RO:0000052 UBERON:0001288 ! inheres in loop of Henle [Term] id: OBA:VT0010067 @@ -188522,8 +289674,8 @@ def: "The morphology of a renal convoluted tubule." [AUTO:patterns/patterns/enti synonym: "morphology of renal convoluted tubule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002703 ! kidney tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006534 ! renal convoluted tubule -relationship: inheres_in UBERON:0006534 ! renal convoluted tubule +intersection_of: RO:0000052 UBERON:0006534 ! inheres in renal convoluted tubule +relationship: RO:0000052 UBERON:0006534 ! inheres in renal convoluted tubule [Term] id: OBA:VT0010068 @@ -188533,8 +289685,8 @@ synonym: "morphology of collecting duct of renal tubule" EXACT [AUTO:patterns/pa is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001232 ! collecting duct of renal tubule -relationship: inheres_in UBERON:0001232 ! collecting duct of renal tubule +intersection_of: RO:0000052 UBERON:0001232 ! inheres in collecting duct of renal tubule +relationship: RO:0000052 UBERON:0001232 ! inheres in collecting duct of renal tubule [Term] id: OBA:VT0010069 @@ -188543,8 +289695,8 @@ def: "The morphology of a proximal convoluted tubule." [AUTO:patterns/patterns/e synonym: "morphology of proximal convoluted tubule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010067 ! convoluted tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001287 ! proximal convoluted tubule -relationship: inheres_in UBERON:0001287 ! proximal convoluted tubule +intersection_of: RO:0000052 UBERON:0001287 ! inheres in proximal convoluted tubule +relationship: RO:0000052 UBERON:0001287 ! inheres in proximal convoluted tubule [Term] id: OBA:VT0010070 @@ -188553,8 +289705,8 @@ def: "The morphology of a distal convoluted tubule." [AUTO:patterns/patterns/ent synonym: "morphology of distal convoluted tubule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010067 ! convoluted tubule morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001292 ! distal convoluted tubule -relationship: inheres_in UBERON:0001292 ! distal convoluted tubule +intersection_of: RO:0000052 UBERON:0001292 ! inheres in distal convoluted tubule +relationship: RO:0000052 UBERON:0001292 ! inheres in distal convoluted tubule [Term] id: OBA:VT0010071 @@ -188564,7 +289716,7 @@ synonym: "morphology of lymphatic part of lymphoid system" EXACT [AUTO:patterns/ is_a: OBA:1000506 ! lymphatic part of lymphoid system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0006558 ! lymphatic part of lymphoid system +intersection_of: RO:0000052 UBERON:0006558 ! inheres in lymphatic part of lymphoid system [Term] id: OBA:VT0010073 @@ -188574,7 +289726,7 @@ synonym: "length of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000006 ! esophagus size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:VT0010075 @@ -188583,8 +289735,8 @@ def: "The morphology of a occipitomastoid suture." [AUTO:patterns/patterns/entit synonym: "morphology of occipitomastoid suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010159 ! occipitomastoid suture -relationship: inheres_in UBERON:0010159 ! occipitomastoid suture +intersection_of: RO:0000052 UBERON:0010159 ! inheres in occipitomastoid suture +relationship: RO:0000052 UBERON:0010159 ! inheres in occipitomastoid suture [Term] id: OBA:VT0010076 @@ -188593,8 +289745,8 @@ def: "The morphology of a parietomastoid suture." [AUTO:patterns/patterns/entity synonym: "morphology of parietomastoid suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010155 ! parietomastoid suture -relationship: inheres_in UBERON:0010155 ! parietomastoid suture +intersection_of: RO:0000052 UBERON:0010155 ! inheres in parietomastoid suture +relationship: RO:0000052 UBERON:0010155 ! inheres in parietomastoid suture [Term] id: OBA:VT0010077 @@ -188603,8 +289755,8 @@ def: "The morphology of a sphenofrontal suture." [AUTO:patterns/patterns/entity_ synonym: "morphology of sphenofrontal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010156 ! sphenofrontal suture -relationship: inheres_in UBERON:0010156 ! sphenofrontal suture +intersection_of: RO:0000052 UBERON:0010156 ! inheres in sphenofrontal suture +relationship: RO:0000052 UBERON:0010156 ! inheres in sphenofrontal suture [Term] id: OBA:VT0010078 @@ -188613,8 +289765,8 @@ def: "The morphology of a sphenoparietal suture." [AUTO:patterns/patterns/entity synonym: "morphology of sphenoparietal suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010157 ! sphenoparietal suture -relationship: inheres_in UBERON:0010157 ! sphenoparietal suture +intersection_of: RO:0000052 UBERON:0010157 ! inheres in sphenoparietal suture +relationship: RO:0000052 UBERON:0010157 ! inheres in sphenoparietal suture [Term] id: OBA:VT0010079 @@ -188623,8 +289775,8 @@ def: "The morphology of a sphenozygomatic suture." [AUTO:patterns/patterns/entit synonym: "morphology of sphenozygomatic suture" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002835 ! cranial suture morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010158 ! sphenozygomatic suture -relationship: inheres_in UBERON:0010158 ! sphenozygomatic suture +intersection_of: RO:0000052 UBERON:0010158 ! inheres in sphenozygomatic suture +relationship: RO:0000052 UBERON:0010158 ! inheres in sphenozygomatic suture [Term] id: OBA:VT0010080 @@ -188634,8 +289786,8 @@ synonym: "functionality of skeletal muscle tissue" EXACT [AUTO:patterns/patterns is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue -relationship: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue +relationship: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:VT0010081 @@ -188645,7 +289797,7 @@ synonym: "morphology of maxillary sinus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000631 ! maxillary sinus quality is_a: OBA:VT0002240 ! paranasal sinus morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001764 ! maxillary sinus +intersection_of: RO:0000052 UBERON:0001764 ! inheres in maxillary sinus [Term] id: OBA:VT0010082 @@ -188655,8 +289807,8 @@ synonym: "morphology of zygomatic process of maxilla" EXACT [AUTO:patterns/patte is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0016477 ! zygomatic process of maxilla -relationship: inheres_in UBERON:0016477 ! zygomatic process of maxilla +intersection_of: RO:0000052 UBERON:0016477 ! inheres in zygomatic process of maxilla +relationship: RO:0000052 UBERON:0016477 ! inheres in zygomatic process of maxilla [Term] id: OBA:VT0010083 @@ -188666,7 +289818,7 @@ synonym: "morphology of frontal process of maxilla" EXACT [AUTO:patterns/pattern is_a: OBA:1000160 ! frontal process of maxilla quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013767 ! frontal process of maxilla +intersection_of: RO:0000052 UBERON:0013767 ! inheres in frontal process of maxilla [Term] id: OBA:VT0010084 @@ -188675,8 +289827,8 @@ def: "The morphology of a long lived plasma cell." [AUTO:patterns/patterns/entit synonym: "morphology of long lived plasma cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002439 ! plasma cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000974 ! long lived plasma cell -relationship: inheres_in CL:0000974 ! long lived plasma cell +intersection_of: RO:0000052 CL:0000974 ! inheres in long lived plasma cell +relationship: RO:0000052 CL:0000974 ! inheres in long lived plasma cell [Term] id: OBA:VT0010085 @@ -188685,8 +289837,8 @@ def: "The morphology of a short lived plasma cell." [AUTO:patterns/patterns/enti synonym: "morphology of short lived plasma cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002439 ! plasma cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000975 ! short lived plasma cell -relationship: inheres_in CL:0000975 ! short lived plasma cell +intersection_of: RO:0000052 CL:0000975 ! inheres in short lived plasma cell +relationship: RO:0000052 CL:0000975 ! inheres in short lived plasma cell [Term] id: OBA:VT0010086 @@ -188696,8 +289848,8 @@ synonym: "morphology of vertebral column" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001130 ! vertebral column -relationship: inheres_in UBERON:0001130 ! vertebral column +intersection_of: RO:0000052 UBERON:0001130 ! inheres in vertebral column +relationship: RO:0000052 UBERON:0001130 ! inheres in vertebral column [Term] id: OBA:VT0010087 @@ -188708,7 +289860,7 @@ is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: OBA:1000066 ! endochondral bone morphology is_a: OBA:1000416 ! ischium quality intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001274 ! ischium +intersection_of: RO:0000052 UBERON:0001274 ! inheres in ischium [Term] id: OBA:VT0010088 @@ -188718,8 +289870,8 @@ synonym: "morphology of pubis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003356 ! pelvic girdle bone/zone morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001275 ! pubis -relationship: inheres_in UBERON:0001275 ! pubis +intersection_of: RO:0000052 UBERON:0001275 ! inheres in pubis +relationship: RO:0000052 UBERON:0001275 ! inheres in pubis [Term] id: OBA:VT0010089 @@ -188729,8 +289881,8 @@ synonym: "morphology of pectoral girdle region" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001421 ! pectoral girdle region -relationship: inheres_in UBERON:0001421 ! pectoral girdle region +intersection_of: RO:0000052 UBERON:0001421 ! inheres in pectoral girdle region +relationship: RO:0000052 UBERON:0001421 ! inheres in pectoral girdle region [Term] id: OBA:VT0010090 @@ -188740,8 +289892,8 @@ synonym: "morphology of pelvic girdle region" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001271 ! pelvic girdle region -relationship: inheres_in UBERON:0001271 ! pelvic girdle region +intersection_of: RO:0000052 UBERON:0001271 ! inheres in pelvic girdle region +relationship: RO:0000052 UBERON:0001271 ! inheres in pelvic girdle region [Term] id: OBA:VT0010091 @@ -188751,8 +289903,8 @@ synonym: "morphology of appendicular skeleton" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002091 ! appendicular skeleton -relationship: inheres_in UBERON:0002091 ! appendicular skeleton +intersection_of: RO:0000052 UBERON:0002091 ! inheres in appendicular skeleton +relationship: RO:0000052 UBERON:0002091 ! inheres in appendicular skeleton [Term] id: OBA:VT0010092 @@ -188762,8 +289914,8 @@ synonym: "morphology of thoracic rib cage" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003252 ! thoracic rib cage -relationship: inheres_in UBERON:0003252 ! thoracic rib cage +intersection_of: RO:0000052 UBERON:0003252 ! inheres in thoracic rib cage +relationship: RO:0000052 UBERON:0003252 ! inheres in thoracic rib cage [Term] id: OBA:VT0010093 @@ -188772,8 +289924,8 @@ def: "The morphology of a costal cartilage." [AUTO:patterns/patterns/entity_attr synonym: "morphology of costal cartilage" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002355 ! cartilage element morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002236 ! costal cartilage -relationship: inheres_in UBERON:0002236 ! costal cartilage +intersection_of: RO:0000052 UBERON:0002236 ! inheres in costal cartilage +relationship: RO:0000052 UBERON:0002236 ! inheres in costal cartilage [Term] id: OBA:VT0010094 @@ -188782,8 +289934,8 @@ def: "The morphology of a osteoblast." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of osteoblast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000062 ! osteoblast -relationship: inheres_in CL:0000062 ! osteoblast +intersection_of: RO:0000052 CL:0000062 ! inheres in osteoblast +relationship: RO:0000052 CL:0000062 ! inheres in osteoblast [Term] id: OBA:VT0010095 @@ -188792,8 +289944,8 @@ def: "The morphology of a osteoclast." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of osteoclast" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004339 ! myeloid leukocyte morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000092 ! osteoclast -relationship: inheres_in CL:0000092 ! osteoclast +intersection_of: RO:0000052 CL:0000092 ! inheres in osteoclast +relationship: RO:0000052 CL:0000092 ! inheres in osteoclast [Term] id: OBA:VT0010096 @@ -188803,8 +289955,8 @@ synonym: "has number of of osteoblast" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000062 ! osteoblast -relationship: inheres_in CL:0000062 ! osteoblast +intersection_of: RO:0000052 CL:0000062 ! inheres in osteoblast +relationship: RO:0000052 CL:0000062 ! inheres in osteoblast [Term] id: OBA:VT0010097 @@ -188813,8 +289965,8 @@ def: "The morphology of a osteocyte." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of osteocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1001065 ! cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000137 ! osteocyte -relationship: inheres_in CL:0000137 ! osteocyte +intersection_of: RO:0000052 CL:0000137 ! inheres in osteocyte +relationship: RO:0000052 CL:0000137 ! inheres in osteocyte [Term] id: OBA:VT0010098 @@ -188824,8 +289976,8 @@ synonym: "has number of of osteoclast" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:1000243 ! myeloid leukocyte quality is_a: OBA:VT0010191 ! immune system cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000092 ! osteoclast -relationship: inheres_in CL:0000092 ! osteoclast +intersection_of: RO:0000052 CL:0000092 ! inheres in osteoclast +relationship: RO:0000052 CL:0000092 ! inheres in osteoclast [Term] id: OBA:VT0010099 @@ -188835,8 +289987,8 @@ synonym: "functionality of egg cell" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0003194 ! cell functionality is_a: OBA:1000722 ! gamete quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in CL:0000025 ! egg cell -relationship: inheres_in CL:0000025 ! egg cell +intersection_of: RO:0000052 CL:0000025 ! inheres in egg cell +relationship: RO:0000052 CL:0000025 ! inheres in egg cell [Term] id: OBA:VT0010104 @@ -188845,8 +289997,8 @@ def: "The morphology of a forelimb long bone." [AUTO:patterns/patterns/entity_at synonym: "morphology of forelimb long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005468 ! limb long bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003607 ! forelimb long bone -relationship: inheres_in UBERON:0003607 ! forelimb long bone +intersection_of: RO:0000052 UBERON:0003607 ! inheres in forelimb long bone +relationship: RO:0000052 UBERON:0003607 ! inheres in forelimb long bone [Term] id: OBA:VT0010105 @@ -188855,8 +290007,8 @@ def: "The morphology of a hindlimb long bone." [AUTO:patterns/patterns/entity_at synonym: "morphology of hindlimb long bone" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005468 ! limb long bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003608 ! hindlimb long bone -relationship: inheres_in UBERON:0003608 ! hindlimb long bone +intersection_of: RO:0000052 UBERON:0003608 ! inheres in hindlimb long bone +relationship: RO:0000052 UBERON:0003608 ! inheres in hindlimb long bone [Term] id: OBA:VT0010106 @@ -188865,8 +290017,8 @@ def: "The morphology of a limb muscle." [AUTO:patterns/patterns/entity_attribute synonym: "morphology of limb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003661 ! limb muscle -relationship: inheres_in UBERON:0003661 ! limb muscle +intersection_of: RO:0000052 UBERON:0003661 ! inheres in limb muscle +relationship: RO:0000052 UBERON:0003661 ! inheres in limb muscle [Term] id: OBA:VT0010107 @@ -188875,8 +290027,8 @@ def: "The morphology of a hindlimb muscle." [AUTO:patterns/patterns/entity_attri synonym: "morphology of hindlimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010106 ! limb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003663 ! hindlimb muscle -relationship: inheres_in UBERON:0003663 ! hindlimb muscle +intersection_of: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle +relationship: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle [Term] id: OBA:VT0010108 @@ -188885,8 +290037,8 @@ def: "The morphology of a hippocampal pyramidal neuron." [AUTO:patterns/patterns synonym: "morphology of hippocampal pyramidal neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:1001571 ! hippocampal pyramidal neuron -relationship: inheres_in CL:1001571 ! hippocampal pyramidal neuron +intersection_of: RO:0000052 CL:1001571 ! inheres in hippocampal pyramidal neuron +relationship: RO:0000052 CL:1001571 ! inheres in hippocampal pyramidal neuron [Term] id: OBA:VT0010110 @@ -188896,8 +290048,8 @@ synonym: "functionality of myocardium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002349 ! myocardium -relationship: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium +relationship: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:VT0010111 @@ -188907,8 +290059,8 @@ synonym: "functionality of smooth muscle tissue" EXACT [AUTO:patterns/patterns/e is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001135 ! smooth muscle tissue -relationship: inheres_in UBERON:0001135 ! smooth muscle tissue +intersection_of: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue +relationship: RO:0000052 UBERON:0001135 ! inheres in smooth muscle tissue [Term] id: OBA:VT0010112 @@ -188918,8 +290070,8 @@ synonym: "morphology of intercalated disc" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0014704 ! intercalated disc -relationship: inheres_in GO:0014704 ! intercalated disc +intersection_of: RO:0000052 GO:0014704 ! inheres in intercalated disc +relationship: RO:0000052 GO:0014704 ! inheres in intercalated disc [Term] id: OBA:VT0010113 @@ -188929,7 +290081,7 @@ synonym: "size of masticatory muscle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0004234 ! masticatory muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003681 ! masticatory muscle +intersection_of: RO:0000052 UBERON:0003681 ! inheres in masticatory muscle [Term] id: OBA:VT0010114 @@ -188939,7 +290091,7 @@ synonym: "size of intercostal muscle" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0002280 ! intercostal muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001111 ! intercostal muscle +intersection_of: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle [Term] id: OBA:VT0010115 @@ -188949,7 +290101,7 @@ synonym: "size of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0002279 ! diaphragm morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:VT0010116 @@ -188959,7 +290111,7 @@ synonym: "size of pectoral muscle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0003346 ! pectoralis muscle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001495 ! pectoral muscle +intersection_of: RO:0000052 UBERON:0001495 ! inheres in pectoral muscle [Term] id: OBA:VT0010117 @@ -188969,7 +290121,7 @@ synonym: "size of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT1000706 ! longissimus dorsi morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT0010120 @@ -188979,7 +290131,7 @@ synonym: "amount of protein" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100005 ! protein attribute is_a: OBA:1000947 ! nitrogen molecular entity amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in PR:000000001 ! protein +intersection_of: RO:0000052 PR:000000001 ! inheres in protein [Term] id: OBA:VT0010122 @@ -188989,8 +290141,8 @@ synonym: "morphology of somite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002329 ! somite -relationship: inheres_in UBERON:0002329 ! somite +intersection_of: RO:0000052 UBERON:0002329 ! inheres in somite +relationship: RO:0000052 UBERON:0002329 ! inheres in somite [Term] id: OBA:VT0010125 @@ -189000,7 +290152,7 @@ synonym: "size of celiac lymph node" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:VT0000701 ! lymph node size trait is_a: OBA:VT0009626 ! celiac lymph node morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002508 ! celiac lymph node +intersection_of: RO:0000052 UBERON:0002508 ! inheres in celiac lymph node [Term] id: OBA:VT0010127 @@ -189009,8 +290161,8 @@ def: "The size of a bursa of Fabricius." [AUTO:patterns/patterns/entity_attribut synonym: "size of bursa of Fabricius" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003535 ! hemopoietic organ size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003903 ! bursa of Fabricius -relationship: inheres_in UBERON:0003903 ! bursa of Fabricius +intersection_of: RO:0000052 UBERON:0003903 ! inheres in bursa of Fabricius +relationship: RO:0000052 UBERON:0003903 ! inheres in bursa of Fabricius [Term] id: OBA:VT0010129 @@ -189020,8 +290172,8 @@ synonym: "mass of esophagus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001043 ! esophagus -relationship: inheres_in UBERON:0001043 ! esophagus +intersection_of: RO:0000052 UBERON:0001043 ! inheres in esophagus +relationship: RO:0000052 UBERON:0001043 ! inheres in esophagus [Term] id: OBA:VT0010130 @@ -189030,8 +290182,8 @@ def: "The has number of of a DN1 thymic pro-T cell." [AUTO:patterns/patterns/ent synonym: "has number of of DN1 thymic pro-T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000237 ! blood cell quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000894 ! DN1 thymic pro-T cell -relationship: inheres_in CL:0000894 ! DN1 thymic pro-T cell +intersection_of: RO:0000052 CL:0000894 ! inheres in DN1 thymic pro-T cell +relationship: RO:0000052 CL:0000894 ! inheres in DN1 thymic pro-T cell [Term] id: OBA:VT0010131 @@ -189041,8 +290193,8 @@ synonym: "mass of caecum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001153 ! caecum -relationship: inheres_in UBERON:0001153 ! caecum +intersection_of: RO:0000052 UBERON:0001153 ! inheres in caecum +relationship: RO:0000052 UBERON:0001153 ! inheres in caecum [Term] id: OBA:VT0010132 @@ -189052,7 +290204,7 @@ synonym: "has number of of DN2 thymocyte" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:1000886 ! DN2 thymocyte quality is_a: OBA:VT0000715 ! thymocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000806 ! DN2 thymocyte +intersection_of: RO:0000052 CL:0000806 ! inheres in DN2 thymocyte [Term] id: OBA:VT0010133 @@ -189062,7 +290214,7 @@ synonym: "volume of gizzard" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010199 ! stomach capacity is_a: OBA:VT1000667 ! gizzard morphology trait intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0005052 ! gizzard +intersection_of: RO:0000052 UBERON:0005052 ! inheres in gizzard [Term] id: OBA:VT0010134 @@ -189071,8 +290223,8 @@ def: "The has number of of a DN3 thymocyte." [AUTO:patterns/patterns/entity_attr synonym: "has number of of DN3 thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000715 ! thymocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000807 ! DN3 thymocyte -relationship: inheres_in CL:0000807 ! DN3 thymocyte +intersection_of: RO:0000052 CL:0000807 ! inheres in DN3 thymocyte +relationship: RO:0000052 CL:0000807 ! inheres in DN3 thymocyte [Term] id: OBA:VT0010136 @@ -189081,8 +290233,8 @@ def: "The has number of of a DN4 thymocyte." [AUTO:patterns/patterns/entity_attr synonym: "has number of of DN4 thymocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000715 ! thymocyte quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000808 ! DN4 thymocyte -relationship: inheres_in CL:0000808 ! DN4 thymocyte +intersection_of: RO:0000052 CL:0000808 ! inheres in DN4 thymocyte +relationship: RO:0000052 CL:0000808 ! inheres in DN4 thymocyte [Term] id: OBA:VT0010139 @@ -189091,8 +290243,8 @@ def: "The quality of a immune response." [AUTO:patterns/patterns/entity_attribut synonym: "quality of immune response" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006955 ! immune response -relationship: inheres_in GO:0006955 ! immune response +intersection_of: RO:0000052 GO:0006955 ! inheres in immune response +relationship: RO:0000052 GO:0006955 ! inheres in immune response [Term] id: OBA:VT0010140 @@ -189102,8 +290254,8 @@ synonym: "mass of small intestine" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002108 ! small intestine -relationship: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine +relationship: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:VT0010143 @@ -189113,8 +290265,8 @@ synonym: "amount of nerve fiber" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0006134 ! nerve fiber -relationship: inheres_in UBERON:0006134 ! nerve fiber +intersection_of: RO:0000052 UBERON:0006134 ! inheres in nerve fiber +relationship: RO:0000052 UBERON:0006134 ! inheres in nerve fiber [Term] id: OBA:VT0010144 @@ -189124,8 +290276,8 @@ synonym: "mass of pancreas" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001264 ! pancreas -relationship: inheres_in UBERON:0001264 ! pancreas +intersection_of: RO:0000052 UBERON:0001264 ! inheres in pancreas +relationship: RO:0000052 UBERON:0001264 ! inheres in pancreas [Term] id: OBA:VT0010145 @@ -189135,8 +290287,8 @@ synonym: "mass of rectum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001052 ! rectum -relationship: inheres_in UBERON:0001052 ! rectum +intersection_of: RO:0000052 UBERON:0001052 ! inheres in rectum +relationship: RO:0000052 UBERON:0001052 ! inheres in rectum [Term] id: OBA:VT0010162 @@ -189146,8 +290298,8 @@ synonym: "functionality of interleukin-10" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100005 ! protein attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in PR:000001471 ! interleukin-10 -relationship: inheres_in PR:000001471 ! interleukin-10 +intersection_of: RO:0000052 PR:000001471 ! inheres in interleukin-10 +relationship: RO:0000052 PR:000001471 ! inheres in interleukin-10 [Term] id: OBA:VT0010179 @@ -189156,8 +290308,8 @@ def: "The quality of a immune system development." [AUTO:patterns/patterns/entit synonym: "quality of immune system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0002520 ! immune system development -relationship: inheres_in GO:0002520 ! immune system development +intersection_of: RO:0000052 GO:0002520 ! inheres in immune system development +relationship: RO:0000052 GO:0002520 ! inheres in immune system development [Term] id: OBA:VT0010183 @@ -189166,8 +290318,8 @@ def: "The morphology of a nucleated thrombocyte." [AUTO:patterns/patterns/entity synonym: "morphology of nucleated thrombocyte" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005896 ! myeloid cell morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000762 ! nucleated thrombocyte -relationship: inheres_in CL:0000762 ! nucleated thrombocyte +intersection_of: RO:0000052 CL:0000762 ! inheres in nucleated thrombocyte +relationship: RO:0000052 CL:0000762 ! inheres in nucleated thrombocyte [Term] id: OBA:VT0010184 @@ -189176,8 +290328,8 @@ def: "The quality of a lymphocyte proliferation." [AUTO:patterns/patterns/entity synonym: "quality of lymphocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010417 ! leukocyte proliferation trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0046651 ! lymphocyte proliferation -relationship: inheres_in GO:0046651 ! lymphocyte proliferation +intersection_of: RO:0000052 GO:0046651 ! inheres in lymphocyte proliferation +relationship: RO:0000052 GO:0046651 ! inheres in lymphocyte proliferation [Term] id: OBA:VT0010191 @@ -189193,8 +290345,8 @@ def: "The morphology of a CD4-negative, CD8-negative, alpha-beta intraepithelial synonym: "morphology of CD4-negative, CD8-negative, alpha-beta intraepithelial T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008399 ! alpha-beta intraepithelial T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000935 ! CD4-negative, CD8-negative, alpha-beta intraepithelial T cell -relationship: inheres_in CL:0000935 ! CD4-negative, CD8-negative, alpha-beta intraepithelial T cell +intersection_of: RO:0000052 CL:0000935 ! inheres in CD4-negative, CD8-negative, alpha-beta intraepithelial T cell +relationship: RO:0000052 CL:0000935 ! inheres in CD4-negative, CD8-negative, alpha-beta intraepithelial T cell [Term] id: OBA:VT0010193 @@ -189204,7 +290356,7 @@ synonym: "length of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002731 ! colon size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:VT0010194 @@ -189214,8 +290366,8 @@ synonym: "mass of colon" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001155 ! colon -relationship: inheres_in UBERON:0001155 ! colon +intersection_of: RO:0000052 UBERON:0001155 ! inheres in colon +relationship: RO:0000052 UBERON:0001155 ! inheres in colon [Term] id: OBA:VT0010195 @@ -189225,7 +290377,7 @@ synonym: "length of intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002616 ! intestine size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:VT0010196 @@ -189235,8 +290387,8 @@ synonym: "mass of intestine" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000160 ! intestine -relationship: inheres_in UBERON:0000160 ! intestine +intersection_of: RO:0000052 UBERON:0000160 ! inheres in intestine +relationship: RO:0000052 UBERON:0000160 ! inheres in intestine [Term] id: OBA:VT0010197 @@ -189247,7 +290399,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0003271 ! duodenum morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002114 ! duodenum +intersection_of: RO:0000052 UBERON:0002114 ! inheres in duodenum [Term] id: OBA:VT0010198 @@ -189257,8 +290409,8 @@ synonym: "mass of duodenum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002114 ! duodenum -relationship: inheres_in UBERON:0002114 ! duodenum +intersection_of: RO:0000052 UBERON:0002114 ! inheres in duodenum +relationship: RO:0000052 UBERON:0002114 ! inheres in duodenum [Term] id: OBA:VT0010199 @@ -189268,7 +290420,7 @@ synonym: "volume of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0003883 ! stomach size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:VT0010200 @@ -189278,8 +290430,8 @@ synonym: "mass of stomach" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000945 ! stomach -relationship: inheres_in UBERON:0000945 ! stomach +intersection_of: RO:0000052 UBERON:0000945 ! inheres in stomach +relationship: RO:0000052 UBERON:0000945 ! inheres in stomach [Term] id: OBA:VT0010201 @@ -189290,8 +290442,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000767 ! smooth muscle morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0004222 ! stomach smooth muscle -relationship: inheres_in UBERON:0004222 ! stomach smooth muscle +intersection_of: RO:0000052 UBERON:0004222 ! inheres in stomach smooth muscle +relationship: RO:0000052 UBERON:0004222 ! inheres in stomach smooth muscle [Term] id: OBA:VT0010202 @@ -189301,7 +290453,7 @@ synonym: "thickness of epithelium of stomach" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0004139 ! epithelium of stomach size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001276 ! epithelium of stomach +intersection_of: RO:0000052 UBERON:0001276 ! inheres in epithelium of stomach [Term] id: OBA:VT0010203 @@ -189310,8 +290462,8 @@ def: "The morphology of a proventriculus." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of proventriculus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005877 ! stomach glandular region morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007357 ! proventriculus -relationship: inheres_in UBERON:0007357 ! proventriculus +intersection_of: RO:0000052 UBERON:0007357 ! inheres in proventriculus +relationship: RO:0000052 UBERON:0007357 ! inheres in proventriculus [Term] id: OBA:VT0010204 @@ -189322,7 +290474,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010203 ! proventriculus morphology trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0007357 ! proventriculus +intersection_of: RO:0000052 UBERON:0007357 ! inheres in proventriculus [Term] id: OBA:VT0010205 @@ -189332,8 +290484,8 @@ synonym: "mass of proventriculus" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007357 ! proventriculus -relationship: inheres_in UBERON:0007357 ! proventriculus +intersection_of: RO:0000052 UBERON:0007357 ! inheres in proventriculus +relationship: RO:0000052 UBERON:0007357 ! inheres in proventriculus [Term] id: OBA:VT0010208 @@ -189344,7 +290496,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010221 ! duodenum mucosa morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000320 ! duodenal mucosa +intersection_of: RO:0000052 UBERON:0000320 ! inheres in duodenal mucosa [Term] id: OBA:VT0010212 @@ -189354,7 +290506,7 @@ synonym: "length of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005467 ! jejunum size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002115 ! jejunum +intersection_of: RO:0000052 UBERON:0002115 ! inheres in jejunum [Term] id: OBA:VT0010213 @@ -189364,8 +290516,8 @@ synonym: "mass of jejunum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002115 ! jejunum -relationship: inheres_in UBERON:0002115 ! jejunum +intersection_of: RO:0000052 UBERON:0002115 ! inheres in jejunum +relationship: RO:0000052 UBERON:0002115 ! inheres in jejunum [Term] id: OBA:VT0010215 @@ -189376,7 +290528,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010222 ! jejunum mucosa morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000399 ! jejunal mucosa +intersection_of: RO:0000052 UBERON:0000399 ! inheres in jejunal mucosa [Term] id: OBA:VT0010219 @@ -189387,7 +290539,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000489 ! large intestine morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000059 ! large intestine +intersection_of: RO:0000052 UBERON:0000059 ! inheres in large intestine [Term] id: OBA:VT0010220 @@ -189397,8 +290549,8 @@ synonym: "mass of large intestine" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000059 ! large intestine -relationship: inheres_in UBERON:0000059 ! large intestine +intersection_of: RO:0000052 UBERON:0000059 ! inheres in large intestine +relationship: RO:0000052 UBERON:0000059 ! inheres in large intestine [Term] id: OBA:VT0010221 @@ -189407,8 +290559,8 @@ def: "The morphology of a duodenal mucosa." [AUTO:patterns/patterns/entity_attri synonym: "morphology of duodenal mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000511 ! intestinal mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000320 ! duodenal mucosa -relationship: inheres_in UBERON:0000320 ! duodenal mucosa +intersection_of: RO:0000052 UBERON:0000320 ! inheres in duodenal mucosa +relationship: RO:0000052 UBERON:0000320 ! inheres in duodenal mucosa [Term] id: OBA:VT0010222 @@ -189417,8 +290569,8 @@ def: "The morphology of a jejunal mucosa." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of jejunal mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000511 ! intestinal mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000399 ! jejunal mucosa -relationship: inheres_in UBERON:0000399 ! jejunal mucosa +intersection_of: RO:0000052 UBERON:0000399 ! inheres in jejunal mucosa +relationship: RO:0000052 UBERON:0000399 ! inheres in jejunal mucosa [Term] id: OBA:VT0010223 @@ -189427,8 +290579,8 @@ def: "The morphology of a ileal mucosa." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of ileal mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000511 ! intestinal mucosa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000331 ! ileal mucosa -relationship: inheres_in UBERON:0000331 ! ileal mucosa +intersection_of: RO:0000052 UBERON:0000331 ! inheres in ileal mucosa +relationship: RO:0000052 UBERON:0000331 ! inheres in ileal mucosa [Term] id: OBA:VT0010224 @@ -189438,7 +290590,7 @@ synonym: "length of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004737 ! ileum size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:VT0010225 @@ -189448,8 +290600,8 @@ synonym: "mass of ileum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002116 ! ileum -relationship: inheres_in UBERON:0002116 ! ileum +intersection_of: RO:0000052 UBERON:0002116 ! inheres in ileum +relationship: RO:0000052 UBERON:0002116 ! inheres in ileum [Term] id: OBA:VT0010227 @@ -189460,7 +290612,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010223 ! ileum mucosa morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000331 ! ileal mucosa +intersection_of: RO:0000052 UBERON:0000331 ! inheres in ileal mucosa [Term] id: OBA:VT0010232 @@ -189471,8 +290623,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000511 ! intestinal mucosa morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000317 ! colonic mucosa -relationship: inheres_in UBERON:0000317 ! colonic mucosa +intersection_of: RO:0000052 UBERON:0000317 ! inheres in colonic mucosa +relationship: RO:0000052 UBERON:0000317 ! inheres in colonic mucosa [Term] id: OBA:VT0010234 @@ -189481,8 +290633,8 @@ def: "The thickness of a cecum mucosa." [AUTO:patterns/patterns/entity_attribute synonym: "thickness of cecum mucosa" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010232 ! colon mucosa thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0000314 ! cecum mucosa -relationship: inheres_in UBERON:0000314 ! cecum mucosa +intersection_of: RO:0000052 UBERON:0000314 ! inheres in cecum mucosa +relationship: RO:0000052 UBERON:0000314 ! inheres in cecum mucosa [Term] id: OBA:VT0010235 @@ -189492,8 +290644,8 @@ synonym: "morphology of ruminant forestomach" EXACT [AUTO:patterns/patterns/enti is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007359 ! ruminant forestomach -relationship: inheres_in UBERON:0007359 ! ruminant forestomach +intersection_of: RO:0000052 UBERON:0007359 ! inheres in ruminant forestomach +relationship: RO:0000052 UBERON:0007359 ! inheres in ruminant forestomach [Term] id: OBA:VT0010236 @@ -189504,7 +290656,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010235 ! forestomach morphology trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0007359 ! ruminant forestomach +intersection_of: RO:0000052 UBERON:0007359 ! inheres in ruminant forestomach [Term] id: OBA:VT0010237 @@ -189514,8 +290666,8 @@ synonym: "mass of ruminant forestomach" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007359 ! ruminant forestomach -relationship: inheres_in UBERON:0007359 ! ruminant forestomach +intersection_of: RO:0000052 UBERON:0007359 ! inheres in ruminant forestomach +relationship: RO:0000052 UBERON:0007359 ! inheres in ruminant forestomach [Term] id: OBA:VT0010238 @@ -189525,8 +290677,8 @@ synonym: "morphology of crop" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007356 ! crop -relationship: inheres_in UBERON:0007356 ! crop +intersection_of: RO:0000052 UBERON:0007356 ! inheres in crop +relationship: RO:0000052 UBERON:0007356 ! inheres in crop [Term] id: OBA:VT0010239 @@ -189536,8 +290688,8 @@ synonym: "mass of crop" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007356 ! crop -relationship: inheres_in UBERON:0007356 ! crop +intersection_of: RO:0000052 UBERON:0007356 ! inheres in crop +relationship: RO:0000052 UBERON:0007356 ! inheres in crop [Term] id: OBA:VT0010240 @@ -189547,8 +290699,8 @@ synonym: "morphology of reticulorumen" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007364 ! reticulorumen -relationship: inheres_in UBERON:0007364 ! reticulorumen +intersection_of: RO:0000052 UBERON:0007364 ! inheres in reticulorumen +relationship: RO:0000052 UBERON:0007364 ! inheres in reticulorumen [Term] id: OBA:VT0010241 @@ -189559,7 +290711,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010240 ! reticulo-rumen morphology trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0007364 ! reticulorumen +intersection_of: RO:0000052 UBERON:0007364 ! inheres in reticulorumen [Term] id: OBA:VT0010242 @@ -189569,8 +290721,8 @@ synonym: "mass of reticulorumen" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007364 ! reticulorumen -relationship: inheres_in UBERON:0007364 ! reticulorumen +intersection_of: RO:0000052 UBERON:0007364 ! inheres in reticulorumen +relationship: RO:0000052 UBERON:0007364 ! inheres in reticulorumen [Term] id: OBA:VT0010244 @@ -189580,8 +290732,8 @@ synonym: "morphology of rumen papilla" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010153 ! rumen papilla -relationship: inheres_in UBERON:0010153 ! rumen papilla +intersection_of: RO:0000052 UBERON:0010153 ! inheres in rumen papilla +relationship: RO:0000052 UBERON:0010153 ! inheres in rumen papilla [Term] id: OBA:VT0010245 @@ -189591,8 +290743,8 @@ synonym: "morphology of omasum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0007362 ! omasum -relationship: inheres_in UBERON:0007362 ! omasum +intersection_of: RO:0000052 UBERON:0007362 ! inheres in omasum +relationship: RO:0000052 UBERON:0007362 ! inheres in omasum [Term] id: OBA:VT0010246 @@ -189603,7 +290755,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010245 ! omasum morphology trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0007362 ! omasum +intersection_of: RO:0000052 UBERON:0007362 ! inheres in omasum [Term] id: OBA:VT0010247 @@ -189613,8 +290765,8 @@ synonym: "mass of omasum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007362 ! omasum -relationship: inheres_in UBERON:0007362 ! omasum +intersection_of: RO:0000052 UBERON:0007362 ! inheres in omasum +relationship: RO:0000052 UBERON:0007362 ! inheres in omasum [Term] id: OBA:VT0010248 @@ -189623,8 +290775,8 @@ def: "The quality when measured in hemolymphoid system." [AUTO:patterns/patterns synonym: "hemolymphoid system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002193 ! hemolymphoid system -relationship: inheres_in UBERON:0002193 ! hemolymphoid system +intersection_of: RO:0000052 UBERON:0002193 ! inheres in hemolymphoid system +relationship: RO:0000052 UBERON:0002193 ! inheres in hemolymphoid system [Term] id: OBA:VT0010250 @@ -189634,7 +290786,7 @@ synonym: "morphology of hematopoietic system" EXACT [AUTO:patterns/patterns/enti is_a: OBA:1000617 ! hematopoietic system quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002390 ! hematopoietic system +intersection_of: RO:0000052 UBERON:0002390 ! inheres in hematopoietic system [Term] id: OBA:VT0010252 @@ -189644,7 +290796,7 @@ synonym: "morphology of hemolymphoid system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0010248 ! hemolymphoid system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002193 ! hemolymphoid system +intersection_of: RO:0000052 UBERON:0002193 ! inheres in hemolymphoid system [Term] id: OBA:VT0010256 @@ -189653,8 +290805,8 @@ def: "The quality when measured in colostrum." [AUTO:patterns/patterns/attribute synonym: "colostrum quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001914 ! colostrum -relationship: inheres_in UBERON:0001914 ! colostrum +intersection_of: RO:0000052 UBERON:0001914 ! inheres in colostrum +relationship: RO:0000052 UBERON:0001914 ! inheres in colostrum [Term] id: OBA:VT0010264 @@ -189665,7 +290817,7 @@ is_a: OBA:VT0000000 ! mammary gland secreted fluid morphology trait is_a: OBA:VT0010256 ! colostrum trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001914 ! colostrum +intersection_of: RO:0000052 UBERON:0001914 ! inheres in colostrum [Term] id: OBA:VT0010267 @@ -189710,7 +290862,7 @@ synonym: "orientation of ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002074 ! ear position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0001690 ! ear +intersection_of: RO:0000052 UBERON:0001690 ! inheres in ear [Term] id: OBA:VT0010275 @@ -189803,6 +290955,7 @@ name: milk chloride amount def: "The amount of a chloride when measured in milk." [AUTO:patterns/patterns/entity_attribute_location] synonym: "milk chloride amount" EXACT [AUTO:patterns/patterns/entity_attribute_location] is_a: OBA:1000959 ! chloride amount +is_a: OBA:VT0010288 ! milk mineral amount [Term] id: OBA:VT0010295 @@ -189819,7 +290972,7 @@ synonym: "size of cardiac ventricle" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0005294 ! heart ventricle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002082 ! cardiac ventricle +intersection_of: RO:0000052 UBERON:0002082 ! inheres in cardiac ventricle [Term] id: OBA:VT0010302 @@ -189899,7 +291052,7 @@ synonym: "diameter of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001127 ! ovary size trait is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:VT0010380 @@ -189938,7 +291091,7 @@ synonym: "length of fallopian tube" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0003576 ! oviduct size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0003889 ! fallopian tube +intersection_of: RO:0000052 UBERON:0003889 ! inheres in fallopian tube [Term] id: OBA:VT0010385 @@ -189984,8 +291137,8 @@ synonym: "morphology of uterine horn" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002247 ! uterine horn -relationship: inheres_in UBERON:0002247 ! uterine horn +intersection_of: RO:0000052 UBERON:0002247 ! inheres in uterine horn +relationship: RO:0000052 UBERON:0002247 ! inheres in uterine horn [Term] id: OBA:VT0010395 @@ -189995,7 +291148,7 @@ synonym: "thickness of endometrium" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0004342 ! endometrium size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001295 ! endometrium +intersection_of: RO:0000052 UBERON:0001295 ! inheres in endometrium [Term] id: OBA:VT0010399 @@ -190019,7 +291172,7 @@ synonym: "size of ovarian follicle" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001131 ! ovarian follicle morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001305 ! ovarian follicle +intersection_of: RO:0000052 UBERON:0001305 ! inheres in ovarian follicle [Term] id: OBA:VT0010402 @@ -190029,7 +291182,7 @@ synonym: "size of corpus luteum" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000655 ! sex gland size trait is_a: OBA:VT0002679 ! corpus luteum morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002512 ! corpus luteum +intersection_of: RO:0000052 UBERON:0002512 ! inheres in corpus luteum [Term] id: OBA:VT0010403 @@ -190039,8 +291192,8 @@ synonym: "shape of cervical os" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0013758 ! cervical os -relationship: inheres_in UBERON:0013758 ! cervical os +intersection_of: RO:0000052 UBERON:0013758 ! inheres in cervical os +relationship: RO:0000052 UBERON:0013758 ! inheres in cervical os [Term] id: OBA:VT0010405 @@ -190050,7 +291203,7 @@ synonym: "size of sperm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004085 ! male germ cell size is_a: OBA:VT0010042 ! sperm morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000019 ! sperm +intersection_of: RO:0000052 CL:0000019 ! inheres in sperm [Term] id: OBA:VT0010406 @@ -190060,7 +291213,7 @@ synonym: "size of sperm flagellum" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0000051 ! cell projection size is_a: OBA:0004523 ! sperm flagellum morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in GO:0036126 ! sperm flagellum +intersection_of: RO:0000052 GO:0036126 ! inheres in sperm flagellum [Term] id: OBA:VT0010413 @@ -190069,8 +291222,8 @@ def: "The quality of a luteinizing hormone secretion." [AUTO:patterns/patterns/e synonym: "quality of luteinizing hormone secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0032275 ! luteinizing hormone secretion -relationship: inheres_in GO:0032275 ! luteinizing hormone secretion +intersection_of: RO:0000052 GO:0032275 ! inheres in luteinizing hormone secretion +relationship: RO:0000052 GO:0032275 ! inheres in luteinizing hormone secretion [Term] id: OBA:VT0010414 @@ -190079,8 +291232,8 @@ def: "The quality of a follicle-stimulating hormone secretion." [AUTO:patterns/p synonym: "quality of follicle-stimulating hormone secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0046884 ! follicle-stimulating hormone secretion -relationship: inheres_in GO:0046884 ! follicle-stimulating hormone secretion +intersection_of: RO:0000052 GO:0046884 ! inheres in follicle-stimulating hormone secretion +relationship: RO:0000052 GO:0046884 ! inheres in follicle-stimulating hormone secretion [Term] id: OBA:VT0010415 @@ -190089,8 +291242,8 @@ def: "The quality of a prolactin secretion." [AUTO:patterns/patterns/entity_attr synonym: "quality of prolactin secretion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070459 ! prolactin secretion -relationship: inheres_in GO:0070459 ! prolactin secretion +intersection_of: RO:0000052 GO:0070459 ! inheres in prolactin secretion +relationship: RO:0000052 GO:0070459 ! inheres in prolactin secretion [Term] id: OBA:VT0010417 @@ -190099,8 +291252,8 @@ def: "The quality of a leukocyte proliferation." [AUTO:patterns/patterns/entity_ synonym: "quality of leukocyte proliferation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070661 ! leukocyte proliferation -relationship: inheres_in GO:0070661 ! leukocyte proliferation +intersection_of: RO:0000052 GO:0070661 ! inheres in leukocyte proliferation +relationship: RO:0000052 GO:0070661 ! inheres in leukocyte proliferation [Term] id: OBA:VT0010418 @@ -190109,8 +291262,8 @@ def: "The morphology of a CD8-positive, CD25-positive, alpha-beta regulatory T c synonym: "morphology of CD8-positive, CD25-positive, alpha-beta regulatory T cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0008398 ! CD8-positive, alpha-beta regulatory T cell morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000919 ! CD8-positive, CD25-positive, alpha-beta regulatory T cell -relationship: inheres_in CL:0000919 ! CD8-positive, CD25-positive, alpha-beta regulatory T cell +intersection_of: RO:0000052 CL:0000919 ! inheres in CD8-positive, CD25-positive, alpha-beta regulatory T cell +relationship: RO:0000052 CL:0000919 ! inheres in CD8-positive, CD25-positive, alpha-beta regulatory T cell [Term] id: OBA:VT0010420 @@ -190120,8 +291273,8 @@ synonym: "mass of adrenal gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002369 ! adrenal gland -relationship: inheres_in UBERON:0002369 ! adrenal gland +intersection_of: RO:0000052 UBERON:0002369 ! inheres in adrenal gland +relationship: RO:0000052 UBERON:0002369 ! inheres in adrenal gland [Term] id: OBA:VT0010421 @@ -190131,7 +291284,7 @@ synonym: "mass of epididymal fat pad" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:0004528 ! fat pad mass is_a: OBA:1000778 ! epididymal fat pad quality intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0010412 ! epididymal fat pad +intersection_of: RO:0000052 UBERON:0010412 ! inheres in epididymal fat pad [Term] id: OBA:VT0010422 @@ -190140,8 +291293,8 @@ def: "The mass of a femoral fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of femoral fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0012283 ! femoral fat pad -relationship: inheres_in UBERON:0012283 ! femoral fat pad +intersection_of: RO:0000052 UBERON:0012283 ! inheres in femoral fat pad +relationship: RO:0000052 UBERON:0012283 ! inheres in femoral fat pad [Term] id: OBA:VT0010423 @@ -190150,8 +291303,8 @@ def: "The mass of a gonadal fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of gonadal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003428 ! gonadal fat pad -relationship: inheres_in UBERON:0003428 ! gonadal fat pad +intersection_of: RO:0000052 UBERON:0003428 ! inheres in gonadal fat pad +relationship: RO:0000052 UBERON:0003428 ! inheres in gonadal fat pad [Term] id: OBA:VT0010424 @@ -190160,8 +291313,8 @@ def: "The mass of a inguinal fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of inguinal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0010410 ! inguinal fat pad -relationship: inheres_in UBERON:0010410 ! inguinal fat pad +intersection_of: RO:0000052 UBERON:0010410 ! inheres in inguinal fat pad +relationship: RO:0000052 UBERON:0010410 ! inheres in inguinal fat pad [Term] id: OBA:VT0010425 @@ -190170,8 +291323,8 @@ def: "The mass of a interscapular fat pad." [AUTO:patterns/patterns/entity_attri synonym: "mass of interscapular fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0014396 ! interscapular fat pad -relationship: inheres_in UBERON:0014396 ! interscapular fat pad +intersection_of: RO:0000052 UBERON:0014396 ! inheres in interscapular fat pad +relationship: RO:0000052 UBERON:0014396 ! inheres in interscapular fat pad [Term] id: OBA:VT0010426 @@ -190180,8 +291333,8 @@ def: "The mass of a mammary fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of mammary fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0012282 ! mammary fat pad -relationship: inheres_in UBERON:0012282 ! mammary fat pad +intersection_of: RO:0000052 UBERON:0012282 ! inheres in mammary fat pad +relationship: RO:0000052 UBERON:0012282 ! inheres in mammary fat pad [Term] id: OBA:VT0010427 @@ -190190,8 +291343,8 @@ def: "The mass of a mesenteric fat pad." [AUTO:patterns/patterns/entity_attribut synonym: "mass of mesenteric fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0015143 ! mesenteric fat pad -relationship: inheres_in UBERON:0015143 ! mesenteric fat pad +intersection_of: RO:0000052 UBERON:0015143 ! inheres in mesenteric fat pad +relationship: RO:0000052 UBERON:0015143 ! inheres in mesenteric fat pad [Term] id: OBA:VT0010428 @@ -190201,8 +291354,8 @@ synonym: "mass of parametrial fat pad" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0010427 ! mesenteric fat pad mass is_a: OBA:VT0010431 ! uterine fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0010413 ! parametrial fat pad -relationship: inheres_in UBERON:0010413 ! parametrial fat pad +intersection_of: RO:0000052 UBERON:0010413 ! inheres in parametrial fat pad +relationship: RO:0000052 UBERON:0010413 ! inheres in parametrial fat pad [Term] id: OBA:VT0010429 @@ -190211,8 +291364,8 @@ def: "The mass of a renal fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of renal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT1000711 ! abdominal fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0014464 ! renal fat pad -relationship: inheres_in UBERON:0014464 ! renal fat pad +intersection_of: RO:0000052 UBERON:0014464 ! inheres in renal fat pad +relationship: RO:0000052 UBERON:0014464 ! inheres in renal fat pad [Term] id: OBA:VT0010430 @@ -190221,8 +291374,8 @@ def: "The mass of a retroperitoneal fat pad." [AUTO:patterns/patterns/entity_att synonym: "mass of retroperitoneal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT1000711 ! abdominal fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0010411 ! retroperitoneal fat pad -relationship: inheres_in UBERON:0010411 ! retroperitoneal fat pad +intersection_of: RO:0000052 UBERON:0010411 ! inheres in retroperitoneal fat pad +relationship: RO:0000052 UBERON:0010411 ! inheres in retroperitoneal fat pad [Term] id: OBA:VT0010431 @@ -190231,8 +291384,8 @@ def: "The mass of a uterine fat pad." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of uterine fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004528 ! fat pad mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0014394 ! uterine fat pad -relationship: inheres_in UBERON:0014394 ! uterine fat pad +intersection_of: RO:0000052 UBERON:0014394 ! inheres in uterine fat pad +relationship: RO:0000052 UBERON:0014394 ! inheres in uterine fat pad [Term] id: OBA:VT0010442 @@ -190241,8 +291394,8 @@ def: "The quality of a behavior." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007610 ! behavior -relationship: inheres_in GO:0007610 ! behavior +intersection_of: RO:0000052 GO:0007610 ! inheres in behavior +relationship: RO:0000052 GO:0007610 ! inheres in behavior [Term] id: OBA:VT0010448 @@ -190251,8 +291404,8 @@ def: "The mass of a forelimb muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of forelimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003662 ! forelimb muscle -relationship: inheres_in UBERON:0003662 ! forelimb muscle +intersection_of: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle +relationship: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle [Term] id: OBA:VT0010449 @@ -190261,8 +291414,8 @@ def: "The mass of a hindlimb muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of hindlimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003663 ! hindlimb muscle -relationship: inheres_in UBERON:0003663 ! hindlimb muscle +intersection_of: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle +relationship: RO:0000052 UBERON:0003663 ! inheres in hindlimb muscle [Term] id: OBA:VT0010453 @@ -190272,7 +291425,7 @@ synonym: "mass of abdominal wall" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000561 ! abdominal wall quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003697 ! abdominal wall +intersection_of: RO:0000052 UBERON:0003697 ! inheres in abdominal wall [Term] id: OBA:VT0010454 @@ -190281,8 +291434,8 @@ def: "The quality when measured in multicellular organism." [AUTO:patterns/patte synonym: "multicellular organism quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000468 ! multicellular organism -relationship: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism +relationship: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0010455 @@ -190291,8 +291444,8 @@ def: "The quality of a rhythmic behavior." [AUTO:patterns/patterns/entity_attrib synonym: "quality of rhythmic behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007622 ! rhythmic behavior -relationship: inheres_in GO:0007622 ! rhythmic behavior +intersection_of: RO:0000052 GO:0007622 ! inheres in rhythmic behavior +relationship: RO:0000052 GO:0007622 ! inheres in rhythmic behavior [Term] id: OBA:VT0010456 @@ -190309,7 +291462,7 @@ synonym: "size of platelet" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000055 ! cell size is_a: OBA:0003276 ! platelet morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000233 ! platelet +intersection_of: RO:0000052 CL:0000233 ! inheres in platelet [Term] id: OBA:VT0010458 @@ -190319,7 +291472,7 @@ synonym: "area of external ear" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000017 ! outer ear size trait is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0001691 ! external ear +intersection_of: RO:0000052 UBERON:0001691 ! inheres in external ear [Term] id: OBA:VT0010464 @@ -190328,8 +291481,8 @@ def: "The quality of a fertility." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of fertility" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in PATO:0000274 ! fertility -relationship: inheres_in PATO:0000274 ! fertility +intersection_of: RO:0000052 PATO:0000274 ! inheres in fertility +relationship: RO:0000052 PATO:0000274 ! inheres in fertility [Term] id: OBA:VT0010466 @@ -190339,8 +291492,8 @@ synonym: "mass of prostate gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002367 ! prostate gland -relationship: inheres_in UBERON:0002367 ! prostate gland +intersection_of: RO:0000052 UBERON:0002367 ! inheres in prostate gland +relationship: RO:0000052 UBERON:0002367 ! inheres in prostate gland [Term] id: OBA:VT0010467 @@ -190350,8 +291503,8 @@ synonym: "mass of prostate gland lateral lobe" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0013637 ! prostate gland lateral lobe -relationship: inheres_in UBERON:0013637 ! prostate gland lateral lobe +intersection_of: RO:0000052 UBERON:0013637 ! inheres in prostate gland lateral lobe +relationship: RO:0000052 UBERON:0013637 ! inheres in prostate gland lateral lobe [Term] id: OBA:VT0010468 @@ -190361,8 +291514,8 @@ synonym: "mass of prostate gland ventral lobe" EXACT [AUTO:patterns/patterns/ent is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007615 ! prostate gland ventral lobe -relationship: inheres_in UBERON:0007615 ! prostate gland ventral lobe +intersection_of: RO:0000052 UBERON:0007615 ! inheres in prostate gland ventral lobe +relationship: RO:0000052 UBERON:0007615 ! inheres in prostate gland ventral lobe [Term] id: OBA:VT0010470 @@ -190379,8 +291532,8 @@ def: "The quality of a exploration behavior." [AUTO:patterns/patterns/entity_att synonym: "quality of exploration behavior" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0035640 ! exploration behavior -relationship: inheres_in GO:0035640 ! exploration behavior +intersection_of: RO:0000052 GO:0035640 ! inheres in exploration behavior +relationship: RO:0000052 GO:0035640 ! inheres in exploration behavior [Term] id: OBA:VT0010484 @@ -190396,8 +291549,8 @@ def: "The quality of a response to xenobiotic stimulus." [AUTO:patterns/patterns synonym: "quality of response to xenobiotic stimulus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0009410 ! response to xenobiotic stimulus -relationship: inheres_in GO:0009410 ! response to xenobiotic stimulus +intersection_of: RO:0000052 GO:0009410 ! inheres in response to xenobiotic stimulus +relationship: RO:0000052 GO:0009410 ! inheres in response to xenobiotic stimulus [Term] id: OBA:VT0010489 @@ -190406,8 +291559,8 @@ def: "The quality of a response to alcohol." [AUTO:patterns/patterns/entity_attr synonym: "quality of response to alcohol" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0097305 ! response to alcohol -relationship: inheres_in GO:0097305 ! response to alcohol +intersection_of: RO:0000052 GO:0097305 ! inheres in response to alcohol +relationship: RO:0000052 GO:0097305 ! inheres in response to alcohol [Term] id: OBA:VT0010492 @@ -190417,7 +291570,7 @@ synonym: "diameter of heart left ventricle" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0002753 ! left ventricle size trait is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0002084 ! heart left ventricle +intersection_of: RO:0000052 UBERON:0002084 ! inheres in heart left ventricle [Term] id: OBA:VT0010493 @@ -190427,7 +291580,7 @@ synonym: "diameter of left cardiac atrium" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0000012 ! left atrium size trait is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0002079 ! left cardiac atrium +intersection_of: RO:0000052 UBERON:0002079 ! inheres in left cardiac atrium [Term] id: OBA:VT0010494 @@ -190436,8 +291589,8 @@ def: "The morphology of a lumbar vertebra." [AUTO:patterns/patterns/entity_attri synonym: "morphology of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000137 ! vertebra morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra -relationship: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra +relationship: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT0010495 @@ -190447,8 +291600,8 @@ synonym: "mass of inguinal lymph node" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001542 ! inguinal lymph node -relationship: inheres_in UBERON:0001542 ! inguinal lymph node +intersection_of: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node +relationship: RO:0000052 UBERON:0001542 ! inheres in inguinal lymph node [Term] id: OBA:VT0010496 @@ -190458,7 +291611,7 @@ synonym: "mass of pituitary gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000518 ! pituitary gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000007 ! pituitary gland +intersection_of: RO:0000052 UBERON:0000007 ! inheres in pituitary gland [Term] id: OBA:VT0010498 @@ -190474,8 +291627,8 @@ def: "The amount of a calcium atom." [AUTO:patterns/patterns/entity_attribute] synonym: "amount of calcium atom" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000182 ! nutrient level intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CHEBI:22984 ! calcium atom -relationship: inheres_in CHEBI:22984 ! calcium atom +intersection_of: RO:0000052 CHEBI:22984 ! inheres in calcium atom +relationship: RO:0000052 CHEBI:22984 ! inheres in calcium atom [Term] id: OBA:VT0010502 @@ -190492,8 +291645,8 @@ synonym: "mass of neurocranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001703 ! neurocranium -relationship: inheres_in UBERON:0001703 ! neurocranium +intersection_of: RO:0000052 UBERON:0001703 ! inheres in neurocranium +relationship: RO:0000052 UBERON:0001703 ! inheres in neurocranium [Term] id: OBA:VT0010510 @@ -190503,8 +291656,8 @@ synonym: "mass of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra -relationship: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra +relationship: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT0010514 @@ -190535,7 +291688,7 @@ synonym: "size of neurocranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000074 ! neurocranium morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001703 ! neurocranium +intersection_of: RO:0000052 UBERON:0001703 ! inheres in neurocranium [Term] id: OBA:VT0010518 @@ -190545,7 +291698,7 @@ synonym: "size of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0002823 ! vertebra size is_a: OBA:VT0010494 ! lumbar vertebra morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT0010519 @@ -190562,8 +291715,8 @@ synonym: "mass of seminal vesicle" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000998 ! seminal vesicle -relationship: inheres_in UBERON:0000998 ! seminal vesicle +intersection_of: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle +relationship: RO:0000052 UBERON:0000998 ! inheres in seminal vesicle [Term] id: OBA:VT0010527 @@ -190572,8 +291725,8 @@ def: "The quality of a associative learning." [AUTO:patterns/patterns/entity_att synonym: "quality of associative learning" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010442 ! behavior trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0008306 ! associative learning -relationship: inheres_in GO:0008306 ! associative learning +intersection_of: RO:0000052 GO:0008306 ! inheres in associative learning +relationship: RO:0000052 GO:0008306 ! inheres in associative learning [Term] id: OBA:VT0010536 @@ -190583,8 +291736,8 @@ synonym: "morphology of rostral migratory stream" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008881 ! rostral migratory stream -relationship: inheres_in UBERON:0008881 ! rostral migratory stream +intersection_of: RO:0000052 UBERON:0008881 ! inheres in rostral migratory stream +relationship: RO:0000052 UBERON:0008881 ! inheres in rostral migratory stream [Term] id: OBA:VT0010537 @@ -190594,8 +291747,8 @@ synonym: "morphology of lateral septal nucleus" EXACT [AUTO:patterns/patterns/en is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002667 ! lateral septal nucleus -relationship: inheres_in UBERON:0002667 ! lateral septal nucleus +intersection_of: RO:0000052 UBERON:0002667 ! inheres in lateral septal nucleus +relationship: RO:0000052 UBERON:0002667 ! inheres in lateral septal nucleus [Term] id: OBA:VT0010538 @@ -190605,7 +291758,7 @@ synonym: "size of lateral septal nucleus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0010537 ! lateral septum morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0002667 ! lateral septal nucleus +intersection_of: RO:0000052 UBERON:0002667 ! inheres in lateral septal nucleus [Term] id: OBA:VT0010542 @@ -190615,7 +291768,7 @@ synonym: "thickness of enamel" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002702 ! enamel size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001752 ! enamel +intersection_of: RO:0000052 UBERON:0001752 ! inheres in enamel [Term] id: OBA:VT0010567 @@ -190625,8 +291778,8 @@ synonym: "morphology of thoracic aorta" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001515 ! thoracic aorta -relationship: inheres_in UBERON:0001515 ! thoracic aorta +intersection_of: RO:0000052 UBERON:0001515 ! inheres in thoracic aorta +relationship: RO:0000052 UBERON:0001515 ! inheres in thoracic aorta [Term] id: OBA:VT0010569 @@ -190635,8 +291788,8 @@ def: "The morphology of a quadriceps femoris." [AUTO:patterns/patterns/entity_at synonym: "morphology of quadriceps femoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010107 ! hindlimb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001377 ! quadriceps femoris -relationship: inheres_in UBERON:0001377 ! quadriceps femoris +intersection_of: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris +relationship: RO:0000052 UBERON:0001377 ! inheres in quadriceps femoris [Term] id: OBA:VT0010570 @@ -190646,7 +291799,7 @@ synonym: "area of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0010518 ! lumbar vertebra size trait is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT0010573 @@ -190656,8 +291809,8 @@ synonym: "strength of vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT0001542 ! bone strength trait intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0002412 ! vertebra -relationship: inheres_in UBERON:0002412 ! vertebra +intersection_of: RO:0000052 UBERON:0002412 ! inheres in vertebra +relationship: RO:0000052 UBERON:0002412 ! inheres in vertebra [Term] id: OBA:VT0010574 @@ -190666,8 +291819,8 @@ def: "The strength of a lumbar vertebra." [AUTO:patterns/patterns/entity_attribu synonym: "strength of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010573 ! vertebra strength intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra -relationship: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra +relationship: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT0010608 @@ -190677,8 +291830,8 @@ synonym: "mass of thyroid gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002046 ! thyroid gland -relationship: inheres_in UBERON:0002046 ! thyroid gland +intersection_of: RO:0000052 UBERON:0002046 ! inheres in thyroid gland +relationship: RO:0000052 UBERON:0002046 ! inheres in thyroid gland [Term] id: OBA:VT0010609 @@ -190688,8 +291841,8 @@ synonym: "morphology of areola" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002032 ! areola -relationship: inheres_in UBERON:0002032 ! areola +intersection_of: RO:0000052 UBERON:0002032 ! inheres in areola +relationship: RO:0000052 UBERON:0002032 ! inheres in areola [Term] id: OBA:VT0010610 @@ -190699,8 +291852,8 @@ synonym: "amount of areola" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in UBERON:0002032 ! areola -relationship: inheres_in UBERON:0002032 ! areola +intersection_of: RO:0000052 UBERON:0002032 ! inheres in areola +relationship: RO:0000052 UBERON:0002032 ! inheres in areola [Term] id: OBA:VT0010611 @@ -190710,8 +291863,8 @@ synonym: "mass of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000995 ! uterus -relationship: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus +relationship: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:VT0010612 @@ -190721,8 +291874,8 @@ synonym: "morphology of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003128 ! cranium -relationship: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium +relationship: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:VT0010613 @@ -190732,7 +291885,7 @@ synonym: "size of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010612 ! cranium morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:VT0010614 @@ -190742,8 +291895,8 @@ synonym: "mass of cranium" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003128 ! cranium -relationship: inheres_in UBERON:0003128 ! cranium +intersection_of: RO:0000052 UBERON:0003128 ! inheres in cranium +relationship: RO:0000052 UBERON:0003128 ! inheres in cranium [Term] id: OBA:VT0010629 @@ -190753,8 +291906,8 @@ synonym: "mass of bulbo-urethral gland" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002366 ! bulbo-urethral gland -relationship: inheres_in UBERON:0002366 ! bulbo-urethral gland +intersection_of: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland +relationship: RO:0000052 UBERON:0002366 ! inheres in bulbo-urethral gland [Term] id: OBA:VT0010641 @@ -190763,8 +291916,8 @@ def: "The morphology of a renal artery." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of renal artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001184 ! renal artery -relationship: inheres_in UBERON:0001184 ! renal artery +intersection_of: RO:0000052 UBERON:0001184 ! inheres in renal artery +relationship: RO:0000052 UBERON:0001184 ! inheres in renal artery [Term] id: OBA:VT0010643 @@ -190773,8 +291926,8 @@ def: "The morphology of a iliac artery." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of iliac artery" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005507 ! systemic artery morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005609 ! iliac artery -relationship: inheres_in UBERON:0005609 ! iliac artery +intersection_of: RO:0000052 UBERON:0005609 ! inheres in iliac artery +relationship: RO:0000052 UBERON:0005609 ! inheres in iliac artery [Term] id: OBA:VT0010645 @@ -190783,8 +291936,8 @@ def: "The mass of a biceps brachii." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of biceps brachii" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010448 ! forelimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001507 ! biceps brachii -relationship: inheres_in UBERON:0001507 ! biceps brachii +intersection_of: RO:0000052 UBERON:0001507 ! inheres in biceps brachii +relationship: RO:0000052 UBERON:0001507 ! inheres in biceps brachii [Term] id: OBA:VT0010646 @@ -190793,8 +291946,8 @@ def: "The mass of a biceps femoris." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of biceps femoris" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001374 ! biceps femoris -relationship: inheres_in UBERON:0001374 ! biceps femoris +intersection_of: RO:0000052 UBERON:0001374 ! inheres in biceps femoris +relationship: RO:0000052 UBERON:0001374 ! inheres in biceps femoris [Term] id: OBA:VT0010647 @@ -190803,8 +291956,8 @@ def: "The morphology of a forelimb muscle." [AUTO:patterns/patterns/entity_attri synonym: "morphology of forelimb muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010106 ! limb muscle morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003662 ! forelimb muscle -relationship: inheres_in UBERON:0003662 ! forelimb muscle +intersection_of: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle +relationship: RO:0000052 UBERON:0003662 ! inheres in forelimb muscle [Term] id: OBA:VT0010655 @@ -190815,7 +291968,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT1000664 ! feather morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000022 ! feather +intersection_of: RO:0000052 UBERON:0000022 ! inheres in feather [Term] id: OBA:VT0010656 @@ -190824,8 +291977,8 @@ def: "The morphology of a comb." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of comb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010007 ! skin adnexa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012176 ! comb -relationship: inheres_in UBERON:0012176 ! comb +intersection_of: RO:0000052 UBERON:0012176 ! inheres in comb +relationship: RO:0000052 UBERON:0012176 ! inheres in comb [Term] id: OBA:VT0010657 @@ -190835,7 +291988,7 @@ synonym: "size of comb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010656 ! comb morphology intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0012176 ! comb +intersection_of: RO:0000052 UBERON:0012176 ! inheres in comb [Term] id: OBA:VT0010658 @@ -190845,7 +291998,7 @@ synonym: "shape of comb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010656 ! comb morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0012176 ! comb +intersection_of: RO:0000052 UBERON:0012176 ! inheres in comb [Term] id: OBA:VT0010659 @@ -190855,8 +292008,8 @@ synonym: "morphology of row of feathers" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013512 ! row of feathers -relationship: inheres_in UBERON:0013512 ! row of feathers +intersection_of: RO:0000052 UBERON:0013512 ! inheres in row of feathers +relationship: RO:0000052 UBERON:0013512 ! inheres in row of feathers [Term] id: OBA:VT0010660 @@ -190866,7 +292019,7 @@ synonym: "width of row of feathers" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0010659 ! feather tract morphology is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0013512 ! row of feathers +intersection_of: RO:0000052 UBERON:0013512 ! inheres in row of feathers [Term] id: OBA:VT0010664 @@ -190875,8 +292028,8 @@ def: "The mass of a semimembranosus muscle." [AUTO:patterns/patterns/entity_attr synonym: "mass of semimembranosus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010449 ! hindlimb muscle mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001381 ! semimembranosus muscle -relationship: inheres_in UBERON:0001381 ! semimembranosus muscle +intersection_of: RO:0000052 UBERON:0001381 ! inheres in semimembranosus muscle +relationship: RO:0000052 UBERON:0001381 ! inheres in semimembranosus muscle [Term] id: OBA:VT0010665 @@ -190886,8 +292039,8 @@ synonym: "mass of gluteus medius" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002401 ! muscle organ mass is_a: OBA:1000644 ! gluteal muscle quality intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001371 ! gluteus medius -relationship: inheres_in UBERON:0001371 ! gluteus medius +intersection_of: RO:0000052 UBERON:0001371 ! inheres in gluteus medius +relationship: RO:0000052 UBERON:0001371 ! inheres in gluteus medius [Term] id: OBA:VT0010669 @@ -190897,7 +292050,7 @@ synonym: "width of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT0010117 ! longissimus dorsi size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT0010671 @@ -190907,8 +292060,8 @@ synonym: "morphology of tarsometatarsus" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0003695 ! bone of appendage girdle complex morphology is_a: OBA:1000066 ! endochondral bone morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0008195 ! tarsometatarsus -relationship: inheres_in UBERON:0008195 ! tarsometatarsus +intersection_of: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus +relationship: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus [Term] id: OBA:VT0010672 @@ -190918,8 +292071,8 @@ synonym: "mass of tarsometatarsus" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0008195 ! tarsometatarsus -relationship: inheres_in UBERON:0008195 ! tarsometatarsus +intersection_of: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus +relationship: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus [Term] id: OBA:VT0010673 @@ -190930,7 +292083,7 @@ is_a: OBA:1000138 ! bone element size is_a: OBA:VT0010671 ! tarsometatarsus morphology is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0008195 ! tarsometatarsus +intersection_of: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus [Term] id: OBA:VT0010674 @@ -190941,7 +292094,7 @@ is_a: OBA:1000138 ! bone element size is_a: OBA:VT0010671 ! tarsometatarsus morphology is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0008195 ! tarsometatarsus +intersection_of: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus [Term] id: OBA:VT0010675 @@ -190950,8 +292103,8 @@ def: "The size of a semimembranosus muscle." [AUTO:patterns/patterns/entity_attr synonym: "size of semimembranosus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002449 ! hindlimb stylopod muscle size intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0001381 ! semimembranosus muscle -relationship: inheres_in UBERON:0001381 ! semimembranosus muscle +intersection_of: RO:0000052 UBERON:0001381 ! inheres in semimembranosus muscle +relationship: RO:0000052 UBERON:0001381 ! inheres in semimembranosus muscle [Term] id: OBA:VT0010676 @@ -190961,7 +292114,7 @@ synonym: "width of semimembranosus muscle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0010675 ! semimembranosus size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001381 ! semimembranosus muscle +intersection_of: RO:0000052 UBERON:0001381 ! inheres in semimembranosus muscle [Term] id: OBA:VT0010679 @@ -190972,7 +292125,7 @@ is_a: OBA:1000138 ! bone element size is_a: OBA:VT0010671 ! tarsometatarsus morphology is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0008195 ! tarsometatarsus +intersection_of: RO:0000052 UBERON:0008195 ! inheres in tarsometatarsus [Term] id: OBA:VT0010684 @@ -190982,8 +292135,8 @@ synonym: "morphology of peritoneum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002358 ! peritoneum -relationship: inheres_in UBERON:0002358 ! peritoneum +intersection_of: RO:0000052 UBERON:0002358 ! inheres in peritoneum +relationship: RO:0000052 UBERON:0002358 ! inheres in peritoneum [Term] id: OBA:VT0010693 @@ -190992,8 +292145,8 @@ def: "The morphology of a longissimus muscle." [AUTO:patterns/patterns/entity_at synonym: "morphology of longissimus muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003692 ! muscle organ morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000392 ! longissimus muscle -relationship: inheres_in UBERON:0000392 ! longissimus muscle +intersection_of: RO:0000052 UBERON:0000392 ! inheres in longissimus muscle +relationship: RO:0000052 UBERON:0000392 ! inheres in longissimus muscle [Term] id: OBA:VT0015000 @@ -191003,7 +292156,7 @@ synonym: "morphology of epididymal fat pad" EXACT [AUTO:patterns/patterns/entity is_a: OBA:1000778 ! epididymal fat pad quality is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010412 ! epididymal fat pad +intersection_of: RO:0000052 UBERON:0010412 ! inheres in epididymal fat pad [Term] id: OBA:VT0015001 @@ -191012,8 +292165,8 @@ def: "The morphology of a femoral fat pad." [AUTO:patterns/patterns/entity_attri synonym: "morphology of femoral fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012283 ! femoral fat pad -relationship: inheres_in UBERON:0012283 ! femoral fat pad +intersection_of: RO:0000052 UBERON:0012283 ! inheres in femoral fat pad +relationship: RO:0000052 UBERON:0012283 ! inheres in femoral fat pad [Term] id: OBA:VT0015002 @@ -191022,8 +292175,8 @@ def: "The morphology of a interscapular fat pad." [AUTO:patterns/patterns/entity synonym: "morphology of interscapular fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014396 ! interscapular fat pad -relationship: inheres_in UBERON:0014396 ! interscapular fat pad +intersection_of: RO:0000052 UBERON:0014396 ! inheres in interscapular fat pad +relationship: RO:0000052 UBERON:0014396 ! inheres in interscapular fat pad [Term] id: OBA:VT0015003 @@ -191033,8 +292186,8 @@ synonym: "morphology of mammary fat pad" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0004752 ! mammary gland connective tissue morphology is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0012282 ! mammary fat pad -relationship: inheres_in UBERON:0012282 ! mammary fat pad +intersection_of: RO:0000052 UBERON:0012282 ! inheres in mammary fat pad +relationship: RO:0000052 UBERON:0012282 ! inheres in mammary fat pad [Term] id: OBA:VT0015004 @@ -191043,8 +292196,8 @@ def: "The morphology of a mesenteric fat pad." [AUTO:patterns/patterns/entity_at synonym: "morphology of mesenteric fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0015143 ! mesenteric fat pad -relationship: inheres_in UBERON:0015143 ! mesenteric fat pad +intersection_of: RO:0000052 UBERON:0015143 ! inheres in mesenteric fat pad +relationship: RO:0000052 UBERON:0015143 ! inheres in mesenteric fat pad [Term] id: OBA:VT0015005 @@ -191054,8 +292207,8 @@ synonym: "morphology of parametrial fat pad" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT0015004 ! mesenteric fat pad morphology is_a: OBA:VT0015007 ! uterine fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0010413 ! parametrial fat pad -relationship: inheres_in UBERON:0010413 ! parametrial fat pad +intersection_of: RO:0000052 UBERON:0010413 ! inheres in parametrial fat pad +relationship: RO:0000052 UBERON:0010413 ! inheres in parametrial fat pad [Term] id: OBA:VT0015006 @@ -191064,8 +292217,8 @@ def: "The morphology of a renal fat pad." [AUTO:patterns/patterns/entity_attribu synonym: "morphology of renal fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000010 ! abdominal fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014464 ! renal fat pad -relationship: inheres_in UBERON:0014464 ! renal fat pad +intersection_of: RO:0000052 UBERON:0014464 ! inheres in renal fat pad +relationship: RO:0000052 UBERON:0014464 ! inheres in renal fat pad [Term] id: OBA:VT0015007 @@ -191074,8 +292227,8 @@ def: "The morphology of a uterine fat pad." [AUTO:patterns/patterns/entity_attri synonym: "morphology of uterine fat pad" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005334 ! fat pad morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0014394 ! uterine fat pad -relationship: inheres_in UBERON:0014394 ! uterine fat pad +intersection_of: RO:0000052 UBERON:0014394 ! inheres in uterine fat pad +relationship: RO:0000052 UBERON:0014394 ! inheres in uterine fat pad [Term] id: OBA:VT0015009 @@ -191084,8 +292237,8 @@ def: "The morphology of a white fat cell." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of white fat cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0004128 ! adipocyte morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0000448 ! white fat cell -relationship: inheres_in CL:0000448 ! white fat cell +intersection_of: RO:0000052 CL:0000448 ! inheres in white fat cell +relationship: RO:0000052 CL:0000448 ! inheres in white fat cell [Term] id: OBA:VT0015011 @@ -191095,7 +292248,7 @@ synonym: "size of white fat cell" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004185 ! fat cell size is_a: OBA:VT0015009 ! white adipocyte morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in CL:0000448 ! white fat cell +intersection_of: RO:0000052 CL:0000448 ! inheres in white fat cell [Term] id: OBA:VT0015026 @@ -191105,8 +292258,8 @@ synonym: "amount of neuron" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000076 ! attribute of cell is_a: PATO:0000070 ! amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000540 ! neuron -relationship: inheres_in CL:0000540 ! neuron +intersection_of: RO:0000052 CL:0000540 ! inheres in neuron +relationship: RO:0000052 CL:0000540 ! inheres in neuron [Term] id: OBA:VT0015035 @@ -191116,8 +292269,8 @@ synonym: "morphology of auditory cortex" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001393 ! auditory cortex -relationship: inheres_in UBERON:0001393 ! auditory cortex +intersection_of: RO:0000052 UBERON:0001393 ! inheres in auditory cortex +relationship: RO:0000052 UBERON:0001393 ! inheres in auditory cortex [Term] id: OBA:VT0015037 @@ -191126,8 +292279,8 @@ def: "The quality of a gland development." [AUTO:patterns/patterns/entity_attrib synonym: "quality of gland development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048732 ! gland development -relationship: inheres_in GO:0048732 ! gland development +intersection_of: RO:0000052 GO:0048732 ! inheres in gland development +relationship: RO:0000052 GO:0048732 ! inheres in gland development [Term] id: OBA:VT0015039 @@ -191137,18 +292290,18 @@ synonym: "width of multicellular organism" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0100005 ! body size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0015043 name: milk amount def: "The volume of a milk." [AUTO:patterns/patterns/entity_attribute] synonym: "volume of milk" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:0000036 ! body fluid levels is_a: OBA:VT0000000 ! mammary gland secreted fluid morphology trait -is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0001913 ! milk -relationship: inheres_in UBERON:0001913 ! milk +intersection_of: RO:0000052 UBERON:0001913 ! inheres in milk +relationship: RO:0000052 UBERON:0001913 ! inheres in milk [Term] id: OBA:VT0015044 @@ -191157,8 +292310,8 @@ def: "The morphology of a beak." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of beak" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005094 ! beak -relationship: inheres_in UBERON:0005094 ! beak +intersection_of: RO:0000052 UBERON:0005094 ! inheres in beak +relationship: RO:0000052 UBERON:0005094 ! inheres in beak [Term] id: OBA:VT0015045 @@ -191168,17 +292321,18 @@ synonym: "morphology of thoracic cavity" EXACT [AUTO:patterns/patterns/entity_at is_a: OBA:1000623 ! thoracic cavity quality is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002224 ! thoracic cavity +intersection_of: RO:0000052 UBERON:0002224 ! inheres in thoracic cavity [Term] id: OBA:VT0015046 name: hippocampus neuron morphology trait def: "The morphology of a hippocampal neuron." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of hippocampal neuron" EXACT [AUTO:patterns/patterns/entity_attribute] +is_a: OBA:VT0002181 ! brain cell morphology trait is_a: OBA:VT0002882 ! neuron morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in CL:0002608 ! hippocampal neuron -relationship: inheres_in CL:0002608 ! hippocampal neuron +intersection_of: RO:0000052 CL:0002608 ! inheres in hippocampal neuron +relationship: RO:0000052 CL:0002608 ! inheres in hippocampal neuron [Term] id: OBA:VT0015047 @@ -191187,8 +292341,8 @@ def: "The quality of a head development." [AUTO:patterns/patterns/entity_attribu synonym: "quality of head development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0060322 ! head development -relationship: inheres_in GO:0060322 ! head development +intersection_of: RO:0000052 GO:0060322 ! inheres in head development +relationship: RO:0000052 GO:0060322 ! inheres in head development [Term] id: OBA:VT0015050 @@ -191197,8 +292351,8 @@ def: "The morphology of a paravertebral ganglion." [AUTO:patterns/patterns/entit synonym: "morphology of paravertebral ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001008 ! sympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001807 ! paravertebral ganglion -relationship: inheres_in UBERON:0001807 ! paravertebral ganglion +intersection_of: RO:0000052 UBERON:0001807 ! inheres in paravertebral ganglion +relationship: RO:0000052 UBERON:0001807 ! inheres in paravertebral ganglion [Term] id: OBA:VT0015051 @@ -191207,8 +292361,8 @@ def: "The morphology of a prevertebral ganglion." [AUTO:patterns/patterns/entity synonym: "morphology of prevertebral ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001008 ! sympathetic ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003964 ! prevertebral ganglion -relationship: inheres_in UBERON:0003964 ! prevertebral ganglion +intersection_of: RO:0000052 UBERON:0003964 ! inheres in prevertebral ganglion +relationship: RO:0000052 UBERON:0003964 ! inheres in prevertebral ganglion [Term] id: OBA:VT0015052 @@ -191217,8 +292371,8 @@ def: "The quality of a surface structure." [AUTO:patterns/patterns/entity_attrib synonym: "quality of surface structure" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0003102 ! surface structure -relationship: inheres_in UBERON:0003102 ! surface structure +intersection_of: RO:0000052 UBERON:0003102 ! inheres in surface structure +relationship: RO:0000052 UBERON:0003102 ! inheres in surface structure [Term] id: OBA:VT0015053 @@ -191227,8 +292381,8 @@ def: "The morphology of a opercular flap." [AUTO:patterns/patterns/entity_attrib synonym: "morphology of opercular flap" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015066 ! surface structure morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:2000555 ! opercular flap -relationship: inheres_in UBERON:2000555 ! opercular flap +intersection_of: RO:0000052 UBERON:2000555 ! inheres in opercular flap +relationship: RO:0000052 UBERON:2000555 ! inheres in opercular flap [Term] id: OBA:VT0015054 @@ -191237,8 +292391,8 @@ def: "The morphology of a lumbar dorsal root ganglion." [AUTO:patterns/patterns/ synonym: "morphology of lumbar dorsal root ganglion" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000961 ! dorsal root ganglion morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002836 ! lumbar dorsal root ganglion -relationship: inheres_in UBERON:0002836 ! lumbar dorsal root ganglion +intersection_of: RO:0000052 UBERON:0002836 ! inheres in lumbar dorsal root ganglion +relationship: RO:0000052 UBERON:0002836 ! inheres in lumbar dorsal root ganglion [Term] id: OBA:VT0015055 @@ -191248,8 +292402,8 @@ synonym: "morphology of cloaca" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000162 ! cloaca -relationship: inheres_in UBERON:0000162 ! cloaca +intersection_of: RO:0000052 UBERON:0000162 ! inheres in cloaca +relationship: RO:0000052 UBERON:0000162 ! inheres in cloaca [Term] id: OBA:VT0015057 @@ -191259,7 +292413,7 @@ synonym: "functionality of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005382 ! head trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT0015058 @@ -191269,8 +292423,8 @@ synonym: "functionality of brain" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000955 ! brain -relationship: inheres_in UBERON:0000955 ! brain +intersection_of: RO:0000052 UBERON:0000955 ! inheres in brain +relationship: RO:0000052 UBERON:0000955 ! inheres in brain [Term] id: OBA:VT0015059 @@ -191279,8 +292433,8 @@ def: "The quality of a thoracic segment of trunk." [AUTO:patterns/patterns/entit synonym: "quality of thoracic segment of trunk" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000915 ! thoracic segment of trunk -relationship: inheres_in UBERON:0000915 ! thoracic segment of trunk +intersection_of: RO:0000052 UBERON:0000915 ! inheres in thoracic segment of trunk +relationship: RO:0000052 UBERON:0000915 ! inheres in thoracic segment of trunk [Term] id: OBA:VT0015060 @@ -191289,8 +292443,8 @@ def: "The quality when measured in sacral region." [AUTO:patterns/patterns/attri synonym: "sacral region quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0100003 ! organism subdivision trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0005473 ! sacral region -relationship: inheres_in UBERON:0005473 ! sacral region +intersection_of: RO:0000052 UBERON:0005473 ! inheres in sacral region +relationship: RO:0000052 UBERON:0005473 ! inheres in sacral region [Term] id: OBA:VT0015063 @@ -191300,8 +292454,8 @@ synonym: "morphology of postganglionic parasympathetic fiber" EXACT [AUTO:patter is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011929 ! postganglionic parasympathetic fiber -relationship: inheres_in UBERON:0011929 ! postganglionic parasympathetic fiber +intersection_of: RO:0000052 UBERON:0011929 ! inheres in postganglionic parasympathetic fiber +relationship: RO:0000052 UBERON:0011929 ! inheres in postganglionic parasympathetic fiber [Term] id: OBA:VT0015064 @@ -191311,8 +292465,8 @@ synonym: "morphology of preganglionic parasympathetic fiber" EXACT [AUTO:pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0011930 ! preganglionic parasympathetic fiber -relationship: inheres_in UBERON:0011930 ! preganglionic parasympathetic fiber +intersection_of: RO:0000052 UBERON:0011930 ! inheres in preganglionic parasympathetic fiber +relationship: RO:0000052 UBERON:0011930 ! inheres in preganglionic parasympathetic fiber [Term] id: OBA:VT0015065 @@ -191321,8 +292475,8 @@ def: "The quality when measured in gustatory system." [AUTO:patterns/patterns/at synonym: "gustatory system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001033 ! gustatory system -relationship: inheres_in UBERON:0001033 ! gustatory system +intersection_of: RO:0000052 UBERON:0001033 ! inheres in gustatory system +relationship: RO:0000052 UBERON:0001033 ! inheres in gustatory system [Term] id: OBA:VT0015066 @@ -191332,7 +292486,7 @@ synonym: "morphology of surface structure" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003102 ! surface structure +intersection_of: RO:0000052 UBERON:0003102 ! inheres in surface structure [Term] id: OBA:VT0015068 @@ -191342,7 +292496,7 @@ synonym: "functionality of surface structure" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0015052 ! surface structure trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0003102 ! surface structure +intersection_of: RO:0000052 UBERON:0003102 ! inheres in surface structure [Term] id: OBA:VT0015069 @@ -191351,8 +292505,8 @@ def: "The quality of a appendage development." [AUTO:patterns/patterns/entity_at synonym: "quality of appendage development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048736 ! appendage development -relationship: inheres_in GO:0048736 ! appendage development +intersection_of: RO:0000052 GO:0048736 ! inheres in appendage development +relationship: RO:0000052 GO:0048736 ! inheres in appendage development [Term] id: OBA:VT0015070 @@ -191362,7 +292516,7 @@ synonym: "functionality of appendage" EXACT [AUTO:patterns/patterns/entity_attri is_a: OBA:1000099 ! appendage trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0000026 ! appendage +intersection_of: RO:0000052 UBERON:0000026 ! inheres in appendage [Term] id: OBA:VT0015071 @@ -191372,7 +292526,7 @@ synonym: "morphology of appendage" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000099 ! appendage trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000026 ! appendage +intersection_of: RO:0000052 UBERON:0000026 ! inheres in appendage [Term] id: OBA:VT0015072 @@ -191382,7 +292536,7 @@ synonym: "morphology of paired fin" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:1000100 ! paired fin trait is_a: OBA:VT0015071 ! appendage morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002534 ! paired fin +intersection_of: RO:0000052 UBERON:0002534 ! inheres in paired fin [Term] id: OBA:VT0015073 @@ -191391,8 +292545,8 @@ def: "The quality of a fin regeneration." [AUTO:patterns/patterns/entity_attribu synonym: "quality of fin regeneration" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100007 ! growth trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0031101 ! fin regeneration -relationship: inheres_in GO:0031101 ! fin regeneration +intersection_of: RO:0000052 GO:0031101 ! inheres in fin regeneration +relationship: RO:0000052 GO:0031101 ! inheres in fin regeneration [Term] id: OBA:VT0015074 @@ -191401,8 +292555,8 @@ def: "The quality when measured in anatomical system." [AUTO:patterns/patterns/a synonym: "anatomical system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000467 ! anatomical system -relationship: inheres_in UBERON:0000467 ! anatomical system +intersection_of: RO:0000052 UBERON:0000467 ! inheres in anatomical system +relationship: RO:0000052 UBERON:0000467 ! inheres in anatomical system [Term] id: OBA:VT0015075 @@ -191412,8 +292566,8 @@ synonym: "morphology of styloid process of temporal bone" EXACT [AUTO:patterns/p is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003960 ! styloid process of temporal bone -relationship: inheres_in UBERON:0003960 ! styloid process of temporal bone +intersection_of: RO:0000052 UBERON:0003960 ! inheres in styloid process of temporal bone +relationship: RO:0000052 UBERON:0003960 ! inheres in styloid process of temporal bone [Term] id: OBA:VT0015076 @@ -191423,8 +292577,8 @@ synonym: "morphology of subarcuate fossa" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0003995 ! subarcuate fossa -relationship: inheres_in UBERON:0003995 ! subarcuate fossa +intersection_of: RO:0000052 UBERON:0003995 ! inheres in subarcuate fossa +relationship: RO:0000052 UBERON:0003995 ! inheres in subarcuate fossa [Term] id: OBA:VT0015077 @@ -191433,8 +292587,8 @@ def: "The quality of a chemical homeostasis." [AUTO:patterns/patterns/entity_att synonym: "quality of chemical homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001764 ! homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048878 ! chemical homeostasis -relationship: inheres_in GO:0048878 ! chemical homeostasis +intersection_of: RO:0000052 GO:0048878 ! inheres in chemical homeostasis +relationship: RO:0000052 GO:0048878 ! inheres in chemical homeostasis [Term] id: OBA:VT0015079 @@ -191443,8 +292597,8 @@ def: "The quality of a sterol homeostasis." [AUTO:patterns/patterns/entity_attri synonym: "quality of sterol homeostasis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002118 ! lipid homeostasis trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0055092 ! sterol homeostasis -relationship: inheres_in GO:0055092 ! sterol homeostasis +intersection_of: RO:0000052 GO:0055092 ! inheres in sterol homeostasis +relationship: RO:0000052 GO:0055092 ! inheres in sterol homeostasis [Term] id: OBA:VT0015085 @@ -191453,8 +292607,8 @@ def: "The morphology of a cerebellum vermis lobule." [AUTO:patterns/patterns/ent synonym: "morphology of cerebellum vermis lobule" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004936 ! cerebellum lobule morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004070 ! cerebellum vermis lobule -relationship: inheres_in UBERON:0004070 ! cerebellum vermis lobule +intersection_of: RO:0000052 UBERON:0004070 ! inheres in cerebellum vermis lobule +relationship: RO:0000052 UBERON:0004070 ! inheres in cerebellum vermis lobule [Term] id: OBA:VT0015086 @@ -191470,8 +292624,8 @@ def: "The quality of a vitamin metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of vitamin metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006766 ! vitamin metabolic process -relationship: inheres_in GO:0006766 ! vitamin metabolic process +intersection_of: RO:0000052 GO:0006766 ! inheres in vitamin metabolic process +relationship: RO:0000052 GO:0006766 ! inheres in vitamin metabolic process [Term] id: OBA:VT0015088 @@ -191480,8 +292634,8 @@ def: "The quality of a glucose metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of glucose metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000452 ! carbohydrate metabolic process quality intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006006 ! glucose metabolic process -relationship: inheres_in GO:0006006 ! glucose metabolic process +intersection_of: RO:0000052 GO:0006006 ! inheres in glucose metabolic process +relationship: RO:0000052 GO:0006006 ! inheres in glucose metabolic process [Term] id: OBA:VT0015089 @@ -191490,8 +292644,8 @@ def: "The quality of a alcohol metabolic process." [AUTO:patterns/patterns/entit synonym: "quality of alcohol metabolic process" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002121 ! metabolism trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0006066 ! alcohol metabolic process -relationship: inheres_in GO:0006066 ! alcohol metabolic process +intersection_of: RO:0000052 GO:0006066 ! inheres in alcohol metabolic process +relationship: RO:0000052 GO:0006066 ! inheres in alcohol metabolic process [Term] id: OBA:VT0015094 @@ -191500,8 +292654,8 @@ def: "The quality when measured in vestibular system." [AUTO:patterns/patterns/a synonym: "vestibular system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0004681 ! vestibular system -relationship: inheres_in UBERON:0004681 ! vestibular system +intersection_of: RO:0000052 UBERON:0004681 ! inheres in vestibular system +relationship: RO:0000052 UBERON:0004681 ! inheres in vestibular system [Term] id: OBA:VT0015095 @@ -191510,8 +292664,8 @@ def: "The quality of a sensory perception." [AUTO:patterns/patterns/entity_attri synonym: "quality of sensory perception" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0007600 ! sensory perception -relationship: inheres_in GO:0007600 ! sensory perception +intersection_of: RO:0000052 GO:0007600 ! inheres in sensory perception +relationship: RO:0000052 GO:0007600 ! inheres in sensory perception [Term] id: OBA:VT0015096 @@ -191521,7 +292675,7 @@ synonym: "morphology of vestibular system" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0015094 ! equilibrioception system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0004681 ! vestibular system +intersection_of: RO:0000052 UBERON:0004681 ! inheres in vestibular system [Term] id: OBA:VT0015097 @@ -191530,8 +292684,8 @@ def: "The quality of a equilibrioception." [AUTO:patterns/patterns/entity_attrib synonym: "quality of equilibrioception" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0050957 ! equilibrioception -relationship: inheres_in GO:0050957 ! equilibrioception +intersection_of: RO:0000052 GO:0050957 ! inheres in equilibrioception +relationship: RO:0000052 GO:0050957 ! inheres in equilibrioception [Term] id: OBA:VT0015100 @@ -191540,8 +292694,8 @@ def: "The quality of a sensory perception of pain." [AUTO:patterns/patterns/enti synonym: "quality of sensory perception of pain" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015095 ! sensory trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0019233 ! sensory perception of pain -relationship: inheres_in GO:0019233 ! sensory perception of pain +intersection_of: RO:0000052 GO:0019233 ! inheres in sensory perception of pain +relationship: RO:0000052 GO:0019233 ! inheres in sensory perception of pain [Term] id: OBA:VT0015104 @@ -191550,8 +292704,8 @@ def: "The morphology of a hippocampus pyramidal layer." [AUTO:patterns/patterns/ synonym: "morphology of hippocampus pyramidal layer" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000813 ! hippocampus layer morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002313 ! hippocampus pyramidal layer -relationship: inheres_in UBERON:0002313 ! hippocampus pyramidal layer +intersection_of: RO:0000052 UBERON:0002313 ! inheres in hippocampus pyramidal layer +relationship: RO:0000052 UBERON:0002313 ! inheres in hippocampus pyramidal layer [Term] id: OBA:VT0015105 @@ -191561,8 +292715,8 @@ synonym: "morphology of telencephalon" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001893 ! telencephalon -relationship: inheres_in UBERON:0001893 ! telencephalon +intersection_of: RO:0000052 UBERON:0001893 ! inheres in telencephalon +relationship: RO:0000052 UBERON:0001893 ! inheres in telencephalon [Term] id: OBA:VT0015106 @@ -191572,8 +292726,8 @@ synonym: "morphology of neocortex" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001950 ! neocortex -relationship: inheres_in UBERON:0001950 ! neocortex +intersection_of: RO:0000052 UBERON:0001950 ! inheres in neocortex +relationship: RO:0000052 UBERON:0001950 ! inheres in neocortex [Term] id: OBA:VT0015108 @@ -191583,8 +292737,8 @@ synonym: "morphology of neuron projection" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0100001 ! cellular component attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0043005 ! neuron projection -relationship: inheres_in GO:0043005 ! neuron projection +intersection_of: RO:0000052 GO:0043005 ! inheres in neuron projection +relationship: RO:0000052 GO:0043005 ! inheres in neuron projection [Term] id: OBA:VT0015109 @@ -191593,8 +292747,8 @@ def: "The morphology of a dendrite." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of dendrite" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0015108 ! neurite morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0030425 ! dendrite -relationship: inheres_in GO:0030425 ! dendrite +intersection_of: RO:0000052 GO:0030425 ! inheres in dendrite +relationship: RO:0000052 GO:0030425 ! inheres in dendrite [Term] id: OBA:VT0015110 @@ -191604,7 +292758,7 @@ synonym: "morphology of synapse" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000139 ! synapse structure and activity is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in GO:0045202 ! synapse +intersection_of: RO:0000052 GO:0045202 ! inheres in synapse [Term] id: OBA:VT0015111 @@ -191613,8 +292767,8 @@ def: "The quality of a inner ear development." [AUTO:patterns/patterns/entity_at synonym: "quality of inner ear development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0048839 ! inner ear development -relationship: inheres_in GO:0048839 ! inner ear development +intersection_of: RO:0000052 GO:0048839 ! inheres in inner ear development +relationship: RO:0000052 GO:0048839 ! inheres in inner ear development [Term] id: OBA:VT0100000 @@ -191624,7 +292778,7 @@ synonym: "size of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0005296 ! humerus morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT0100001 @@ -191634,7 +292788,7 @@ synonym: "size of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0000558 ! tibia morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT0100002 @@ -191643,8 +292797,8 @@ def: "The quality of a connective tissue." [AUTO:patterns/patterns/entity_attrib synonym: "quality of connective tissue" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002384 ! connective tissue -relationship: inheres_in UBERON:0002384 ! connective tissue +intersection_of: RO:0000052 UBERON:0002384 ! inheres in connective tissue +relationship: RO:0000052 UBERON:0002384 ! inheres in connective tissue [Term] id: OBA:VT0100003 @@ -191653,8 +292807,8 @@ def: "The quality of a organism subdivision." [AUTO:patterns/patterns/entity_att synonym: "quality of organism subdivision" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0000475 ! organism subdivision -relationship: inheres_in UBERON:0000475 ! organism subdivision +intersection_of: RO:0000052 UBERON:0000475 ! inheres in organism subdivision +relationship: RO:0000052 UBERON:0000475 ! inheres in organism subdivision [Term] id: OBA:VT0100005 @@ -191664,7 +292818,7 @@ synonym: "size of multicellular organism" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0010454 ! organism trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000468 ! multicellular organism +intersection_of: RO:0000052 UBERON:0000468 ! inheres in multicellular organism [Term] id: OBA:VT0100007 @@ -191673,8 +292827,8 @@ def: "The quality of a growth." [AUTO:patterns/patterns/entity_attribute] synonym: "quality of growth" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0040007 ! growth -relationship: inheres_in GO:0040007 ! growth +intersection_of: RO:0000052 GO:0040007 ! inheres in growth +relationship: RO:0000052 GO:0040007 ! inheres in growth [Term] id: OBA:VT0100012 @@ -191684,7 +292838,7 @@ synonym: "functionality of kidney blood vessel" EXACT [AUTO:patterns/patterns/en is_a: OBA:1000818 ! kidney blood vessel quality is_a: OBA:VT0000170 ! blood vessel physiology trait intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0003517 ! kidney blood vessel +intersection_of: RO:0000052 UBERON:0003517 ! inheres in kidney blood vessel [Term] id: OBA:VT0100015 @@ -191693,8 +292847,8 @@ def: "The quality of a circulatory system development." [AUTO:patterns/patterns/ synonym: "quality of circulatory system development" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0072359 ! circulatory system development -relationship: inheres_in GO:0072359 ! circulatory system development +intersection_of: RO:0000052 GO:0072359 ! inheres in circulatory system development +relationship: RO:0000052 GO:0072359 ! inheres in circulatory system development [Term] id: OBA:VT0100016 @@ -191704,7 +292858,7 @@ synonym: "morphology of circulatory system" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT1000784 ! circulatory system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001009 ! circulatory system +intersection_of: RO:0000052 UBERON:0001009 ! inheres in circulatory system [Term] id: OBA:VT0100017 @@ -191714,7 +292868,7 @@ synonym: "functionality of circulatory system" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT1000784 ! circulatory system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001009 ! circulatory system +intersection_of: RO:0000052 UBERON:0001009 ! inheres in circulatory system [Term] id: OBA:VT0100019 @@ -191724,7 +292878,7 @@ synonym: "functionality of integumental system" EXACT [AUTO:patterns/patterns/en is_a: OBA:VT1000775 ! integumentary system trait is_a: PATO:0001509 ! functionality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0002416 ! integumental system +intersection_of: RO:0000052 UBERON:0002416 ! inheres in integumental system [Term] id: OBA:VT0100020 @@ -191734,7 +292888,7 @@ synonym: "morphology of integumental system" EXACT [AUTO:patterns/patterns/entit is_a: OBA:VT1000775 ! integumentary system trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0002416 ! integumental system +intersection_of: RO:0000052 UBERON:0002416 ! inheres in integumental system [Term] id: OBA:VT0100021 @@ -191744,7 +292898,7 @@ synonym: "size of mammary gland alveolus" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0001884 ! mammary alveoli morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0003214 ! mammary gland alveolus +intersection_of: RO:0000052 UBERON:0003214 ! inheres in mammary gland alveolus [Term] id: OBA:VT0100022 @@ -191754,7 +292908,7 @@ synonym: "diameter of mammary gland alveolus" EXACT [AUTO:patterns/patterns/enti is_a: OBA:VT0100021 ! mammary alveoli size trait is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0003214 ! mammary gland alveolus +intersection_of: RO:0000052 UBERON:0003214 ! inheres in mammary gland alveolus [Term] id: OBA:VT0100027 @@ -191764,7 +292918,7 @@ synonym: "shape of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0006078 ! nipple morphology trait is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT0100028 @@ -191774,7 +292928,7 @@ synonym: "diameter of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002334 ! nipple size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT0100030 @@ -191784,7 +292938,7 @@ synonym: "orientation of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002336 ! nipple position is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT0100033 @@ -191794,7 +292948,7 @@ synonym: "circumference of mammary gland" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:VT0010002 ! mammary gland size trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0100034 @@ -191804,8 +292958,8 @@ synonym: "mass of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000057 ! gland quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001911 ! mammary gland -relationship: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland +relationship: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT0100035 @@ -191815,7 +292969,7 @@ synonym: "size of udder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT1000067 ! udder morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0013216 ! udder +intersection_of: RO:0000052 UBERON:0013216 ! inheres in udder [Term] id: OBA:VT0100036 @@ -191825,7 +292979,7 @@ synonym: "volume of mammary gland alveolus" EXACT [AUTO:patterns/patterns/entity is_a: OBA:VT0100021 ! mammary alveoli size trait is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: inheres_in UBERON:0003214 ! mammary gland alveolus +intersection_of: RO:0000052 UBERON:0003214 ! inheres in mammary gland alveolus [Term] id: OBA:VT1000062 @@ -191835,7 +292989,7 @@ synonym: "circumference of chest" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0002620 ! chest size is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:VT1000066 @@ -191846,8 +293000,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001464 ! hip -relationship: inheres_in UBERON:0001464 ! hip +intersection_of: RO:0000052 UBERON:0001464 ! inheres in hip +relationship: RO:0000052 UBERON:0001464 ! inheres in hip [Term] id: OBA:VT1000067 @@ -191857,8 +293011,8 @@ synonym: "morphology of udder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013216 ! udder -relationship: inheres_in UBERON:0013216 ! udder +intersection_of: RO:0000052 UBERON:0013216 ! inheres in udder +relationship: RO:0000052 UBERON:0013216 ! inheres in udder [Term] id: OBA:VT1000111 @@ -191868,8 +293022,8 @@ synonym: "mass of bone element" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001474 ! bone element -relationship: inheres_in UBERON:0001474 ! bone element +intersection_of: RO:0000052 UBERON:0001474 ! inheres in bone element +relationship: RO:0000052 UBERON:0001474 ! inheres in bone element [Term] id: OBA:VT1000120 @@ -191879,7 +293033,7 @@ synonym: "thickness of intercostal muscle" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:VT0010114 ! intercostal muscle size trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001111 ! intercostal muscle +intersection_of: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle [Term] id: OBA:VT1000121 @@ -191888,8 +293042,8 @@ def: "The has number of of a lumbar vertebra." [AUTO:patterns/patterns/entity_at synonym: "has number of of lumbar vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000138 ! vertebra quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002414 ! lumbar vertebra -relationship: inheres_in UBERON:0002414 ! lumbar vertebra +intersection_of: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra +relationship: RO:0000052 UBERON:0002414 ! inheres in lumbar vertebra [Term] id: OBA:VT1000122 @@ -191898,8 +293052,8 @@ def: "The has number of of a thoracic vertebra." [AUTO:patterns/patterns/entity_ synonym: "has number of of thoracic vertebra" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000138 ! vertebra quantity intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002347 ! thoracic vertebra -relationship: inheres_in UBERON:0002347 ! thoracic vertebra +intersection_of: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra +relationship: RO:0000052 UBERON:0002347 ! inheres in thoracic vertebra [Term] id: OBA:VT1000126 @@ -191910,7 +293064,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0000003 ! adipose morphology trait is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: inheres_in UBERON:0001013 ! adipose tissue +intersection_of: RO:0000052 UBERON:0001013 ! inheres in adipose tissue [Term] id: OBA:VT1000146 @@ -191919,8 +293073,8 @@ def: "The mass of a longissimus thoracis muscle." [AUTO:patterns/patterns/entity synonym: "mass of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle -relationship: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle +relationship: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT1000149 @@ -191929,8 +293083,8 @@ def: "The mass of a intercostal muscle." [AUTO:patterns/patterns/entity_attribut synonym: "mass of intercostal muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001111 ! intercostal muscle -relationship: inheres_in UBERON:0001111 ! intercostal muscle +intersection_of: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle +relationship: RO:0000052 UBERON:0001111 ! inheres in intercostal muscle [Term] id: OBA:VT1000165 @@ -191947,7 +293101,7 @@ synonym: "intensity of estrus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000910 ! estrus quality is_a: PATO:0000049 ! intensity intersection_of: PATO:0000049 ! intensity -intersection_of: inheres_in GO:0060209 ! estrus +intersection_of: RO:0000052 GO:0060209 ! inheres in estrus [Term] id: OBA:VT1000205 @@ -191957,7 +293111,7 @@ synonym: "length of nipple" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002334 ! nipple size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT1000206 @@ -191967,8 +293121,8 @@ synonym: "has number of of nipple" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in UBERON:0002030 ! nipple -relationship: inheres_in UBERON:0002030 ! nipple +intersection_of: RO:0000052 UBERON:0002030 ! inheres in nipple +relationship: RO:0000052 UBERON:0002030 ! inheres in nipple [Term] id: OBA:VT1000210 @@ -191978,7 +293132,7 @@ synonym: "circumference of scrotum" EXACT [AUTO:patterns/patterns/entity_attribu is_a: OBA:VT0001150 ! scrotum size trait is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0001300 ! scrotum +intersection_of: RO:0000052 UBERON:0001300 ! inheres in scrotum [Term] id: OBA:VT1000220 @@ -191988,8 +293142,8 @@ synonym: "mass of adipose tissue of abdominal region" EXACT [AUTO:patterns/patte is_a: OBA:VT0100002 ! connective tissue trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0007808 ! adipose tissue of abdominal region -relationship: inheres_in UBERON:0007808 ! adipose tissue of abdominal region +intersection_of: RO:0000052 UBERON:0007808 ! inheres in adipose tissue of abdominal region +relationship: RO:0000052 UBERON:0007808 ! inheres in adipose tissue of abdominal region [Term] id: OBA:VT1000223 @@ -191998,8 +293152,8 @@ def: "The mass of a pectoral muscle." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of pectoral muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001495 ! pectoral muscle -relationship: inheres_in UBERON:0001495 ! pectoral muscle +intersection_of: RO:0000052 UBERON:0001495 ! inheres in pectoral muscle +relationship: RO:0000052 UBERON:0001495 ! inheres in pectoral muscle [Term] id: OBA:VT1000226 @@ -192008,8 +293162,8 @@ def: "The mass of a gizzard." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of gizzard" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010200 ! stomach mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0005052 ! gizzard -relationship: inheres_in UBERON:0005052 ! gizzard +intersection_of: RO:0000052 UBERON:0005052 ! inheres in gizzard +relationship: RO:0000052 UBERON:0005052 ! inheres in gizzard [Term] id: OBA:VT1000276 @@ -192019,7 +293173,7 @@ synonym: "area of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100000 ! humerus size trait is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT1000280 @@ -192029,7 +293183,7 @@ synonym: "width of humerus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100000 ! humerus size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000976 ! humerus +intersection_of: RO:0000052 UBERON:0000976 ! inheres in humerus [Term] id: OBA:VT1000281 @@ -192039,7 +293193,7 @@ synonym: "area of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100001 ! tibia size trait is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT1000284 @@ -192049,7 +293203,7 @@ synonym: "strength of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000340 ! tibia quality is_a: OBA:VT0001542 ! bone strength trait intersection_of: PATO:0001230 ! strength -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT1000286 @@ -192059,7 +293213,7 @@ synonym: "elasticity of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000340 ! tibia quality is_a: OBA:VT0000072 ! bone elasticity trait intersection_of: PATO:0001031 ! elasticity -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT1000289 @@ -192069,7 +293223,7 @@ synonym: "width of tibia" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100001 ! tibia size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000979 ! tibia +intersection_of: RO:0000052 UBERON:0000979 ! inheres in tibia [Term] id: OBA:VT1000294 @@ -192079,8 +293233,8 @@ synonym: "amount of egg cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0003699 ! germ cell amount is_a: OBA:1000722 ! gamete quality intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0000025 ! egg cell -relationship: inheres_in CL:0000025 ! egg cell +intersection_of: RO:0000052 CL:0000025 ! inheres in egg cell +relationship: RO:0000052 CL:0000025 ! inheres in egg cell [Term] id: OBA:VT1000361 @@ -192090,8 +293244,8 @@ synonym: "circumference of metacarpal bone of digit 3" EXACT [AUTO:patterns/patt is_a: OBA:0002195 ! metacarpal bone size is_a: PATO:0001648 ! circumference intersection_of: PATO:0001648 ! circumference -intersection_of: inheres_in UBERON:0003647 ! metacarpal bone of digit 3 -relationship: inheres_in UBERON:0003647 ! metacarpal bone of digit 3 +intersection_of: RO:0000052 UBERON:0003647 ! inheres in metacarpal bone of digit 3 +relationship: RO:0000052 UBERON:0003647 ! inheres in metacarpal bone of digit 3 [Term] id: OBA:VT1000369 @@ -192101,7 +293255,7 @@ synonym: "size of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002651 ! long bone size is_a: OBA:VT0000559 ! femur morphology trait intersection_of: PATO:0000117 ! size -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT1000401 @@ -192117,8 +293271,8 @@ def: "The mass of a diaphragm." [AUTO:patterns/patterns/entity_attribute] synonym: "mass of diaphragm" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002401 ! muscle organ mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001103 ! diaphragm -relationship: inheres_in UBERON:0001103 ! diaphragm +intersection_of: RO:0000052 UBERON:0001103 ! inheres in diaphragm +relationship: RO:0000052 UBERON:0001103 ! inheres in diaphragm [Term] id: OBA:VT1000420 @@ -192128,7 +293282,7 @@ synonym: "mass of head" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0005382 ! head trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000033 ! head +intersection_of: RO:0000052 UBERON:0000033 ! inheres in head [Term] id: OBA:VT1000421 @@ -192138,7 +293292,7 @@ synonym: "length of small intestine" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0002572 ! small intestine size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002108 ! small intestine +intersection_of: RO:0000052 UBERON:0002108 ! inheres in small intestine [Term] id: OBA:VT1000425 @@ -192148,8 +293302,8 @@ synonym: "mass of zone of skin" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000014 ! zone of skin -relationship: inheres_in UBERON:0000014 ! zone of skin +intersection_of: RO:0000052 UBERON:0000014 ! inheres in zone of skin +relationship: RO:0000052 UBERON:0000014 ! inheres in zone of skin [Term] id: OBA:VT1000429 @@ -192203,8 +293357,8 @@ synonym: "conductivity of muscle organ" EXACT [AUTO:patterns/patterns/entity_att is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0001630 ! muscle organ -relationship: inheres_in UBERON:0001630 ! muscle organ +intersection_of: RO:0000052 UBERON:0001630 ! inheres in muscle organ +relationship: RO:0000052 UBERON:0001630 ! inheres in muscle organ [Term] id: OBA:VT1000436 @@ -192214,8 +293368,8 @@ synonym: "conductivity of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/ is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001585 ! conductivity intersection_of: PATO:0001585 ! conductivity -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue -relationship: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue +relationship: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:VT1000444 @@ -192239,7 +293393,7 @@ synonym: "area of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/ent is_a: OBA:VT0010117 ! longissimus dorsi size trait is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT1000575 @@ -192250,7 +293404,7 @@ is_a: OBA:0002879 ! muscle organ size is_a: OBA:VT0003686 ! eye muscle morphology trait is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0004277 ! eye muscle +intersection_of: RO:0000052 UBERON:0004277 ! inheres in eye muscle [Term] id: OBA:VT1000578 @@ -192260,7 +293414,7 @@ synonym: "length of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/e is_a: OBA:VT0010117 ! longissimus dorsi size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT1000612 @@ -192269,8 +293423,8 @@ def: "The amount of a type IIb muscle cell." [AUTO:patterns/patterns/entity_attr synonym: "amount of type IIb muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004713 ! cell of skeletal muscle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002215 ! type IIb muscle cell -relationship: inheres_in CL:0002215 ! type IIb muscle cell +intersection_of: RO:0000052 CL:0002215 ! inheres in type IIb muscle cell +relationship: RO:0000052 CL:0002215 ! inheres in type IIb muscle cell [Term] id: OBA:VT1000639 @@ -192280,7 +293434,7 @@ synonym: "length of uterine horn" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:0004605 ! uterine horn size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0002247 ! uterine horn +intersection_of: RO:0000052 UBERON:0002247 ! inheres in uterine horn [Term] id: OBA:VT1000640 @@ -192290,8 +293444,8 @@ synonym: "mass of uterine horn" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002247 ! uterine horn -relationship: inheres_in UBERON:0002247 ! uterine horn +intersection_of: RO:0000052 UBERON:0002247 ! inheres in uterine horn +relationship: RO:0000052 UBERON:0002247 ! inheres in uterine horn [Term] id: OBA:VT1000641 @@ -192301,7 +293455,7 @@ synonym: "mass of ovary" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000545 ! ovary quality is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000992 ! ovary +intersection_of: RO:0000052 UBERON:0000992 ! inheres in ovary [Term] id: OBA:VT1000642 @@ -192311,7 +293465,7 @@ synonym: "length of uterus" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0002637 ! uterus size trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in UBERON:0000995 ! uterus +intersection_of: RO:0000052 UBERON:0000995 ! inheres in uterus [Term] id: OBA:VT1000644 @@ -192321,8 +293475,8 @@ synonym: "mass of testis" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0000473 ! testis -relationship: inheres_in UBERON:0000473 ! testis +intersection_of: RO:0000052 UBERON:0000473 ! inheres in testis +relationship: RO:0000052 UBERON:0000473 ! inheres in testis [Term] id: OBA:VT1000653 @@ -192332,7 +293486,7 @@ synonym: "length of lactation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0001882 ! lactation trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0007595 ! lactation +intersection_of: RO:0000052 GO:0007595 ! inheres in lactation [Term] id: OBA:VT1000664 @@ -192341,8 +293495,8 @@ def: "The morphology of a feather." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of feather" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010007 ! skin adnexa morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000022 ! feather -relationship: inheres_in UBERON:0000022 ! feather +intersection_of: RO:0000052 UBERON:0000022 ! inheres in feather +relationship: RO:0000052 UBERON:0000022 ! inheres in feather [Term] id: OBA:VT1000666 @@ -192352,7 +293506,7 @@ synonym: "width of femur" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT1000369 ! femur size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0000981 ! femur +intersection_of: RO:0000052 UBERON:0000981 ! inheres in femur [Term] id: OBA:VT1000667 @@ -192361,8 +293515,8 @@ def: "The morphology of a gizzard." [AUTO:patterns/patterns/entity_attribute] synonym: "morphology of gizzard" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000470 ! stomach morphology trait intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005052 ! gizzard -relationship: inheres_in UBERON:0005052 ! gizzard +intersection_of: RO:0000052 UBERON:0005052 ! inheres in gizzard +relationship: RO:0000052 UBERON:0005052 ! inheres in gizzard [Term] id: OBA:VT1000670 @@ -192379,8 +293533,8 @@ synonym: "mass of autopod region" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002470 ! autopod region -relationship: inheres_in UBERON:0002470 ! autopod region +intersection_of: RO:0000052 UBERON:0002470 ! inheres in autopod region +relationship: RO:0000052 UBERON:0002470 ! inheres in autopod region [Term] id: OBA:VT1000687 @@ -192390,8 +293544,8 @@ synonym: "mass of forelimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002102 ! forelimb -relationship: inheres_in UBERON:0002102 ! forelimb +intersection_of: RO:0000052 UBERON:0002102 ! inheres in forelimb +relationship: RO:0000052 UBERON:0002102 ! inheres in forelimb [Term] id: OBA:VT1000688 @@ -192401,8 +293555,8 @@ synonym: "mass of metatarsal bone" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:1000067 ! endochondral bone quality is_a: OBA:VT1000111 ! bone mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001448 ! metatarsal bone -relationship: inheres_in UBERON:0001448 ! metatarsal bone +intersection_of: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone +relationship: RO:0000052 UBERON:0001448 ! inheres in metatarsal bone [Term] id: OBA:VT1000689 @@ -192412,8 +293566,8 @@ synonym: "mass of hindlimb" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:1000099 ! appendage trait is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0002103 ! hindlimb -relationship: inheres_in UBERON:0002103 ! hindlimb +intersection_of: RO:0000052 UBERON:0002103 ! inheres in hindlimb +relationship: RO:0000052 UBERON:0002103 ! inheres in hindlimb [Term] id: OBA:VT1000703 @@ -192423,7 +293577,7 @@ synonym: "depth of udder" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100035 ! udder size trait is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0013216 ! udder +intersection_of: RO:0000052 UBERON:0013216 ! inheres in udder [Term] id: OBA:VT1000704 @@ -192433,7 +293587,7 @@ synonym: "height of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribut is_a: OBA:VT0010002 ! mammary gland size trait is_a: PATO:0000119 ! height intersection_of: PATO:0000119 ! height -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT1000705 @@ -192443,7 +293597,7 @@ synonym: "width of mammary gland" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0010002 ! mammary gland size trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001911 ! mammary gland +intersection_of: RO:0000052 UBERON:0001911 ! inheres in mammary gland [Term] id: OBA:VT1000706 @@ -192452,8 +293606,8 @@ def: "The morphology of a longissimus thoracis muscle." [AUTO:patterns/patterns/ synonym: "morphology of longissimus thoracis muscle" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0010693 ! longissimus muscle morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0001401 ! longissimus thoracis muscle -relationship: inheres_in UBERON:0001401 ! longissimus thoracis muscle +intersection_of: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle +relationship: RO:0000052 UBERON:0001401 ! inheres in longissimus thoracis muscle [Term] id: OBA:VT1000711 @@ -192463,8 +293617,8 @@ synonym: "mass of abdominal fat pad" EXACT [AUTO:patterns/patterns/entity_attrib is_a: OBA:0004528 ! fat pad mass is_a: OBA:VT1000220 ! abdominal adipose amount intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0003427 ! abdominal fat pad -relationship: inheres_in UBERON:0003427 ! abdominal fat pad +intersection_of: RO:0000052 UBERON:0003427 ! inheres in abdominal fat pad +relationship: RO:0000052 UBERON:0003427 ! inheres in abdominal fat pad [Term] id: OBA:VT1000712 @@ -192474,8 +293628,8 @@ synonym: "mass of skeletal muscle tissue" EXACT [AUTO:patterns/patterns/entity_a is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000125 ! mass intersection_of: PATO:0000125 ! mass -intersection_of: inheres_in UBERON:0001134 ! skeletal muscle tissue -relationship: inheres_in UBERON:0001134 ! skeletal muscle tissue +intersection_of: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue +relationship: RO:0000052 UBERON:0001134 ! inheres in skeletal muscle tissue [Term] id: OBA:VT1000731 @@ -192485,7 +293639,7 @@ synonym: "width of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002620 ! chest size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:VT1000732 @@ -192495,7 +293649,7 @@ synonym: "depth of chest" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0002620 ! chest size is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0001443 ! chest +intersection_of: RO:0000052 UBERON:0001443 ! inheres in chest [Term] id: OBA:VT1000733 @@ -192506,8 +293660,8 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: inheres_in UBERON:0015875 ! heel -relationship: inheres_in UBERON:0015875 ! heel +intersection_of: RO:0000052 UBERON:0015875 ! inheres in heel +relationship: RO:0000052 UBERON:0015875 ! inheres in heel [Term] id: OBA:VT1000735 @@ -192517,8 +293671,8 @@ synonym: "orientation of pes" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0100003 ! organism subdivision trait is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation -intersection_of: inheres_in UBERON:0002387 ! pes -relationship: inheres_in UBERON:0002387 ! pes +intersection_of: RO:0000052 UBERON:0002387 ! inheres in pes +relationship: RO:0000052 UBERON:0002387 ! inheres in pes [Term] id: OBA:VT1000739 @@ -192528,7 +293682,7 @@ synonym: "morphology of sacral region" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:VT0015060 ! rump trait is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0005473 ! sacral region +intersection_of: RO:0000052 UBERON:0005473 ! inheres in sacral region [Term] id: OBA:VT1000740 @@ -192539,7 +293693,7 @@ is_a: OBA:0000015 ! anatomical structure size is_a: OBA:VT1000739 ! rump morphology trait is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: inheres_in UBERON:0005473 ! sacral region +intersection_of: RO:0000052 UBERON:0005473 ! inheres in sacral region [Term] id: OBA:VT1000741 @@ -192549,7 +293703,7 @@ synonym: "angle of sacral region" EXACT [AUTO:patterns/patterns/entity_attribute is_a: OBA:VT0015060 ! rump trait is_a: PATO:0002326 ! angle intersection_of: PATO:0002326 ! angle -intersection_of: inheres_in UBERON:0005473 ! sacral region +intersection_of: RO:0000052 UBERON:0005473 ! inheres in sacral region [Term] id: OBA:VT1000742 @@ -192560,7 +293714,7 @@ is_a: OBA:0000057 ! cellular component size is_a: OBA:VT0004090 ! sarcomere morphology trait is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length -intersection_of: inheres_in GO:0030017 ! sarcomere +intersection_of: RO:0000052 GO:0030017 ! inheres in sarcomere [Term] id: OBA:VT1000743 @@ -192570,8 +293724,8 @@ synonym: "has number of of cell of skeletal muscle" EXACT [AUTO:patterns/pattern is_a: OBA:1000076 ! attribute of cell is_a: PATO:0001555 ! has number of intersection_of: PATO:0001555 ! has number of -intersection_of: inheres_in CL:0000188 ! cell of skeletal muscle -relationship: inheres_in CL:0000188 ! cell of skeletal muscle +intersection_of: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle +relationship: RO:0000052 CL:0000188 ! inheres in cell of skeletal muscle [Term] id: OBA:VT1000747 @@ -192580,8 +293734,8 @@ def: "The amount of a type I muscle cell." [AUTO:patterns/patterns/entity_attrib synonym: "amount of type I muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004713 ! cell of skeletal muscle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002211 ! type I muscle cell -relationship: inheres_in CL:0002211 ! type I muscle cell +intersection_of: RO:0000052 CL:0002211 ! inheres in type I muscle cell +relationship: RO:0000052 CL:0002211 ! inheres in type I muscle cell [Term] id: OBA:VT1000748 @@ -192590,8 +293744,8 @@ def: "The amount of a type IIa muscle cell." [AUTO:patterns/patterns/entity_attr synonym: "amount of type IIa muscle cell" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0004713 ! cell of skeletal muscle amount intersection_of: PATO:0000070 ! amount -intersection_of: inheres_in CL:0002214 ! type IIa muscle cell -relationship: inheres_in CL:0002214 ! type IIa muscle cell +intersection_of: RO:0000052 CL:0002214 ! inheres in type IIa muscle cell +relationship: RO:0000052 CL:0002214 ! inheres in type IIa muscle cell [Term] id: OBA:VT1000761 @@ -192599,6 +293753,7 @@ name: muscle nitrogen amount def: "The amount of a dinitrogen when measured in muscle organ." [AUTO:patterns/patterns/entity_attribute_location] synonym: "muscle organ dinitrogen amount" EXACT [AUTO:patterns/patterns/entity_attribute_location] is_a: OBA:1000947 ! nitrogen molecular entity amount +is_a: OBA:VT0000192 ! mineral amount [Term] id: OBA:VT1000764 @@ -192614,8 +293769,8 @@ def: "The quality when measured in integumental system." [AUTO:patterns/patterns synonym: "integumental system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002416 ! integumental system -relationship: inheres_in UBERON:0002416 ! integumental system +intersection_of: RO:0000052 UBERON:0002416 ! inheres in integumental system +relationship: RO:0000052 UBERON:0002416 ! inheres in integumental system [Term] id: OBA:VT1000776 @@ -192624,8 +293779,8 @@ def: "The quality when measured in digestive system." [AUTO:patterns/patterns/at synonym: "digestive system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001007 ! digestive system -relationship: inheres_in UBERON:0001007 ! digestive system +intersection_of: RO:0000052 UBERON:0001007 ! inheres in digestive system +relationship: RO:0000052 UBERON:0001007 ! inheres in digestive system [Term] id: OBA:VT1000777 @@ -192634,8 +293789,8 @@ def: "The quality when measured in renal system." [AUTO:patterns/patterns/attrib synonym: "renal system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001008 ! renal system -relationship: inheres_in UBERON:0001008 ! renal system +intersection_of: RO:0000052 UBERON:0001008 ! inheres in renal system +relationship: RO:0000052 UBERON:0001008 ! inheres in renal system [Term] id: OBA:VT1000781 @@ -192644,8 +293799,8 @@ def: "The quality when measured in nervous system." [AUTO:patterns/patterns/attr synonym: "nervous system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001016 ! nervous system -relationship: inheres_in UBERON:0001016 ! nervous system +intersection_of: RO:0000052 UBERON:0001016 ! inheres in nervous system +relationship: RO:0000052 UBERON:0001016 ! inheres in nervous system [Term] id: OBA:VT1000783 @@ -192654,8 +293809,8 @@ def: "The quality when measured in immune system." [AUTO:patterns/patterns/attri synonym: "immune system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0002405 ! immune system -relationship: inheres_in UBERON:0002405 ! immune system +intersection_of: RO:0000052 UBERON:0002405 ! inheres in immune system +relationship: RO:0000052 UBERON:0002405 ! inheres in immune system [Term] id: OBA:VT1000784 @@ -192664,8 +293819,8 @@ def: "The quality when measured in circulatory system." [AUTO:patterns/patterns/ synonym: "circulatory system quality" EXACT [AUTO:patterns/patterns/attribute_location] is_a: OBA:VT0015074 ! organ system trait intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in UBERON:0001009 ! circulatory system -relationship: inheres_in UBERON:0001009 ! circulatory system +intersection_of: RO:0000052 UBERON:0001009 ! inheres in circulatory system +relationship: RO:0000052 UBERON:0001009 ! inheres in circulatory system [Term] id: OBA:VT2000000 @@ -192674,8 +293829,8 @@ def: "The pressure of a arterial blood." [AUTO:patterns/patterns/entity_attribut synonym: "pressure of arterial blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000183 ! blood pressure trait intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0013755 ! arterial blood -relationship: inheres_in UBERON:0013755 ! arterial blood +intersection_of: RO:0000052 UBERON:0013755 ! inheres in arterial blood +relationship: RO:0000052 UBERON:0013755 ! inheres in arterial blood [Term] id: OBA:VT2000001 @@ -192684,8 +293839,8 @@ def: "The pressure of a capillary blood." [AUTO:patterns/patterns/entity_attribu synonym: "pressure of capillary blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000183 ! blood pressure trait intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0013757 ! capillary blood -relationship: inheres_in UBERON:0013757 ! capillary blood +intersection_of: RO:0000052 UBERON:0013757 ! inheres in capillary blood +relationship: RO:0000052 UBERON:0013757 ! inheres in capillary blood [Term] id: OBA:VT2000002 @@ -192694,8 +293849,8 @@ def: "The pressure of a venous blood." [AUTO:patterns/patterns/entity_attribute] synonym: "pressure of venous blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:VT0000183 ! blood pressure trait intersection_of: PATO:0001025 ! pressure -intersection_of: inheres_in UBERON:0013756 ! venous blood -relationship: inheres_in UBERON:0013756 ! venous blood +intersection_of: RO:0000052 UBERON:0013756 ! inheres in venous blood +relationship: RO:0000052 UBERON:0013756 ! inheres in venous blood [Term] id: OBA:VT2000018 @@ -192705,8 +293860,8 @@ synonym: "contractility of myocardium" EXACT [AUTO:patterns/patterns/entity_attr is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0001579 ! contractility intersection_of: PATO:0001579 ! contractility -intersection_of: inheres_in UBERON:0002349 ! myocardium -relationship: inheres_in UBERON:0002349 ! myocardium +intersection_of: RO:0000052 UBERON:0002349 ! inheres in myocardium +relationship: RO:0000052 UBERON:0002349 ! inheres in myocardium [Term] id: OBA:VT3000001 @@ -192715,8 +293870,8 @@ def: "The quality of a platelet activation." [AUTO:patterns/patterns/entity_attr synonym: "quality of platelet activation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0030168 ! platelet activation -relationship: inheres_in GO:0030168 ! platelet activation +intersection_of: RO:0000052 GO:0030168 ! inheres in platelet activation +relationship: RO:0000052 GO:0030168 ! inheres in platelet activation [Term] id: OBA:VT3000002 @@ -192725,8 +293880,8 @@ def: "The quality of a platelet aggregation." [AUTO:patterns/patterns/entity_att synonym: "quality of platelet aggregation" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100002 ! biological process attribute intersection_of: PATO:0000001 ! quality -intersection_of: inheres_in GO:0070527 ! platelet aggregation -relationship: inheres_in GO:0070527 ! platelet aggregation +intersection_of: RO:0000052 GO:0070527 ! inheres in platelet aggregation +relationship: RO:0000052 GO:0070527 ! inheres in platelet aggregation [Term] id: OBA:VT3000004 @@ -192736,8 +293891,8 @@ synonym: "viscosity of blood" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000992 ! viscosity intersection_of: PATO:0000992 ! viscosity -intersection_of: inheres_in UBERON:0000178 ! blood -relationship: inheres_in UBERON:0000178 ! blood +intersection_of: RO:0000052 UBERON:0000178 ! inheres in blood +relationship: RO:0000052 UBERON:0000178 ! inheres in blood [Term] id: OBA:VT4000007 @@ -192747,7 +293902,7 @@ synonym: "functionality of strand of hair" EXACT [AUTO:patterns/patterns/entity_ is_a: OBA:0005150 ! integumentary adnexa functionality is_a: OBA:1000253 ! strand of hair quality intersection_of: PATO:0001509 ! functionality -intersection_of: inheres_in UBERON:0001037 ! strand of hair +intersection_of: RO:0000052 UBERON:0001037 ! inheres in strand of hair [Term] id: OBA:VT4000009 @@ -192757,8 +293912,8 @@ synonym: "morphology of integumentary system layer" EXACT [AUTO:patterns/pattern is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0013754 ! integumentary system layer -relationship: inheres_in UBERON:0013754 ! integumentary system layer +intersection_of: RO:0000052 UBERON:0013754 ! inheres in integumentary system layer +relationship: RO:0000052 UBERON:0013754 ! inheres in integumentary system layer [Term] id: OBA:VT4000011 @@ -192768,8 +293923,8 @@ synonym: "morphology of endocrine pancreas" EXACT [AUTO:patterns/patterns/entity is_a: OBA:0100003 ! anatomical entity attribute is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000016 ! endocrine pancreas -relationship: inheres_in UBERON:0000016 ! endocrine pancreas +intersection_of: RO:0000052 UBERON:0000016 ! inheres in endocrine pancreas +relationship: RO:0000052 UBERON:0000016 ! inheres in endocrine pancreas [Term] id: OBA:VT4000012 @@ -192778,8 +293933,91 @@ def: "The morphology of a mucous gland." [AUTO:patterns/patterns/entity_attribut synonym: "morphology of mucous gland" EXACT [AUTO:patterns/patterns/entity_attribute] is_a: OBA:0005862 ! exocrine gland morphology intersection_of: PATO:0000051 ! morphology -intersection_of: inheres_in UBERON:0000414 ! mucous gland -relationship: inheres_in UBERON:0000414 ! mucous gland +intersection_of: RO:0000052 UBERON:0000414 ! inheres in mucous gland +relationship: RO:0000052 UBERON:0000414 ! inheres in mucous gland + +[Term] +id: OBI:0000011 +name: planned process +def: "A process that realizes a plan which is the concretization of a plan specification." [] +def: "A processual entity that realizes a plan which is the concretization of a plan specification." [] +is_a: BFO:0000015 ! process + +[Term] +id: OBI:0000112 +name: specimen role +def: "a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation" [] +is_a: BFO:0000023 ! role +is_a: CHEBI:50906 ! role + +[Term] +id: OBI:0000659 +name: specimen collection process +def: "A planned process with the objective of collecting a specimen." [] +is_a: OBI:0000011 ! planned process +intersection_of: OBI:0000011 ! planned process +intersection_of: OBI:0000417 OBI:0000684 ! achieves_planned_objective specimen collection objective +relationship: OBI:0000293 BFO:0000040 ! has_specified_input material entity +relationship: OBI:0000299 OBI:0100051 ! has_specified_output specimen +relationship: OBI:0000417 OBI:0000684 ! achieves_planned_objective specimen collection objective + +[Term] +id: OBI:0000684 +name: specimen collection objective +def: "A objective specification to obtain a material entity for potential use as an input during an investigation." [] +is_a: IAO:0000005 ! objective specification + +[Term] +id: OBI:0002076 +name: collection of specimens +def: "A material entity that has two or more specimens as its parts." [] +is_a: BFO:0000040 ! material entity +intersection_of: BFO:0000040 ! material entity +intersection_of: has_member OBI:0100051 {all_only="true"} ! specimen + +[Term] +id: OBI:0100026 +name: organism +def: "A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs." [] +is_a: BFO:0000040 ! material entity +union_of: NCBITaxon:10239 ! Viruses +union_of: NCBITaxon:2 ! Bacteria +union_of: NCBITaxon:2157 ! Archaea +union_of: NCBITaxon:2759 ! Eukaryota +property_value: IAO:0000111 "organism" xsd:string +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000119 "WEB: http://en.wikipedia.org/wiki/Organism" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl + +[Term] +id: OBI:0100051 +name: specimen +def: "A material entity that has the specimen role." [] +is_a: BFO:0000040 ! material entity +intersection_of: BFO:0000040 ! material entity +intersection_of: has_role OBI:0000112 ! specimen role +relationship: has_role OBI:0000112 ! specimen role + +[Term] +id: OGMS:0000060 +name: bodily process +def: "A process in which at least one bodily component of an organsim participates." [] +comment: From OGMS: http://purl.obolibrary.org/obo/OGMS_0000060 +is_a: BFO:0000015 ! process +relationship: BFO:0000167 OGMS:0000087 ! has participant at all times extended organism +property_value: IAO:0000117 "Albert Goldfain" xsd:string +property_value: IAO:0000119 http://www.jbiomedsem.com/content/1/1/10 xsd:string +property_value: IAO:0000232 "creation date: 2009-06-23T11:53:49Z" xsd:string + +[Term] +id: OGMS:0000087 +name: extended organism +def: "An object aggregate consisting of an organism and all material entities located within the organism, overlapping the organism, or occupying sites formed in part by the organism." [] +comment: From OGMS: http://purl.obolibrary.org/obo/OGMS_0000087 +is_a: BFO:0000040 ! material entity +property_value: IAO:0000117 "Albert Goldfain" xsd:string +property_value: IAO:0000119 http://code.google.com/p/ogms/issues/detail?id=3 xsd:string +property_value: IAO:0000232 "creation date: 2010-01-25T04:51:11Z" xsd:string [Term] id: PATO:0000001 @@ -192788,6 +294026,7 @@ namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] is_a: BFO:0000020 ! specifically dependent continuant +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl property_value: IAO:0000589 "quality (PATO)" xsd:string [Term] @@ -192938,7 +294177,6 @@ name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim -is_a: BFO:0000019 ! quality is_a: PATO:0001241 ! physical object quality [Term] @@ -193020,6 +294258,7 @@ synonym: "presence or absence in organism" EXACT [] synonym: "quantitative" EXACT [] is_a: PATO:0000068 ! qualitative relationship: reciprocal_of PATO:0001555 ! has number of +relationship: RO:0015012 PATO:0001555 ! reciprocal of has number of [Term] id: PATO:0000077 @@ -193093,10 +294332,12 @@ id: PATO:0000122 name: length namespace: quality def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG] +comment: Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion. subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent +property_value: seeAlso https://github.com/pato-ontology/pato/issues/337 xsd:string [Term] id: PATO:0000125 @@ -193228,6 +294469,14 @@ def: "An organismal quality inhering in a bearer by virtue of the bearer's behav synonym: "behavioural quality" EXACT [] is_a: PATO:0001995 ! organismal quality +[Term] +id: PATO:0000261 +name: maturity +namespace: quality +def: "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." [Merriam-Webster:Merriam-Webster] +subset: attribute_slim +is_a: PATO:0001995 ! organismal quality + [Term] id: PATO:0000273 name: fecundity @@ -193286,7 +294535,7 @@ synonym: "high speed" EXACT [] is_a: PATO:0000008 ! speed is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000008 ! speed -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000304 [Term] @@ -193300,7 +294549,7 @@ synonym: "slow speed" EXACT [] is_a: PATO:0000008 ! speed is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000008 ! speed -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000303 [Term] @@ -193335,7 +294584,7 @@ synonym: "high frequency" EXACT [] is_a: PATO:0000044 ! frequency is_a: PATO:0055003 ! increased rate of occurrence intersection_of: PATO:0000044 ! frequency -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000381 [Term] @@ -193350,7 +294599,9 @@ synonym: "low frequency" EXACT [] is_a: PATO:0000044 ! frequency is_a: PATO:0055004 ! decreased rate of occurrence intersection_of: PATO:0000044 ! frequency +intersection_of: PATO:0000044 ! frequency intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000380 [Term] @@ -193385,7 +294636,9 @@ synonym: "tough" RELATED [] is_a: PATO:0000048 ! hardness is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000048 ! hardness +intersection_of: PATO:0000048 ! hardness intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000387 [Term] @@ -193399,9 +294652,17 @@ subset: value_slim is_a: PATO:0000048 ! hardness is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000048 ! hardness +intersection_of: PATO:0000048 ! hardness intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000386 +[Term] +id: PATO:0000389 +name: acute +def: "A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course." [] +is_a: PATO:0001309 ! duration + [Term] id: PATO:0000402 name: branched @@ -193415,6 +294676,17 @@ synonym: "ramiform" EXACT [] is_a: PATO:0002009 ! branchiness property_value: RO:0002604 PATO:0000414 +[Term] +id: PATO:0000406 +name: curved +namespace: quality +def: "A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend." [WordNet:WordNet] +subset: cell_quality +subset: value_slim +synonym: "bowing" NARROW [] +synonym: "curled" RELATED [] +is_a: PATO:0001591 ! curvature + [Term] id: PATO:0000407 name: flat @@ -193449,6 +294721,16 @@ subset: value_slim is_a: PATO:0000060 ! spatial pattern property_value: RO:0002604 PATO:0000330 +[Term] +id: PATO:0000460 +name: abnormal +def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [] +synonym: "aberrant" RELATED [] +synonym: "atypia" RELATED [] +synonym: "atypical" RELATED [] +synonym: "defective" RELATED [] +is_a: PATO:0000069 ! deviation (from_normal) + [Term] id: PATO:0000461 name: normal @@ -193488,7 +294770,9 @@ synonym: "supernumerary" EXACT [] is_a: PATO:0000467 ! present is_a: PATO:0002300 ! increased quality intersection_of: PATO:0000070 ! amount +intersection_of: PATO:0000070 ! amount intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001997 [Term] @@ -193507,7 +294791,9 @@ synonym: "slow time" RELATED [] is_a: PATO:0001309 ! duration is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001309 ! duration +intersection_of: PATO:0001309 ! duration intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000499 [Term] @@ -193525,7 +294811,9 @@ synonym: "shortened period" EXACT [] is_a: PATO:0001309 ! duration is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001309 ! duration +intersection_of: PATO:0001309 ! duration intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000498 [Term] @@ -193538,7 +294826,7 @@ synonym: "short" RELATED [] is_a: PATO:0000119 ! height is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000119 ! height -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000570 [Term] @@ -193551,7 +294839,7 @@ synonym: "tall" RELATED [] is_a: PATO:0000119 ! height is_a: PATO:0000586 ! increased size intersection_of: PATO:0000119 ! height -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000569 [Term] @@ -193564,7 +294852,7 @@ synonym: "long" EXACT [] is_a: PATO:0000122 ! length is_a: PATO:0000586 ! increased size intersection_of: PATO:0000122 ! length -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000574 [Term] @@ -193579,7 +294867,7 @@ synonym: "stubby" RELATED [] is_a: PATO:0000122 ! length is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000122 ! length -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000573 [Term] @@ -193597,7 +294885,9 @@ synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size +intersection_of: PATO:0000117 ! size intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000587 [Term] @@ -193614,7 +294904,9 @@ synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size +intersection_of: PATO:0000117 ! size intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000586 [Term] @@ -193631,7 +294923,7 @@ synonym: "thickened" EXACT [] is_a: PATO:0000586 ! increased size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000592 [Term] @@ -193647,7 +294939,7 @@ synonym: "thin" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000591 [Term] @@ -193662,7 +294954,7 @@ synonym: "large volume" RELATED [] is_a: PATO:0000586 ! increased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000596 [Term] @@ -193677,7 +294969,7 @@ synonym: "small volume" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000595 [Term] @@ -193690,7 +294982,7 @@ synonym: "narrow" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000600 [Term] @@ -193705,9 +294997,26 @@ synonym: "wide/broad" RELATED [] is_a: PATO:0000586 ! increased size is_a: PATO:0000921 ! width intersection_of: PATO:0000921 ! width -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000599 +[Term] +id: PATO:0000608 +name: closed +namespace: quality +def: "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." [answers.com:answers.com] +subset: value_slim +synonym: "blocked" RELATED [] +is_a: PATO:0000136 ! closure +disjoint_from: PATO:0000610 ! open +property_value: RO:0002604 PATO:0000610 + +[Term] +id: PATO:0000610 +name: open +def: "A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view." [] +is_a: PATO:0000136 ! closure + [Term] id: PATO:0000614 name: oriented @@ -193730,7 +295039,7 @@ synonym: "high threshold" EXACT [] is_a: PATO:0000152 ! threshold is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000152 ! threshold -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000708 [Term] @@ -193746,7 +295055,7 @@ synonym: "low threshold" EXACT [] is_a: PATO:0000152 ! threshold is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000152 ! threshold -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000706 [Term] @@ -193760,7 +295069,9 @@ synonym: "slow rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000161 ! rate +intersection_of: PATO:0000161 ! rate intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000912 [Term] @@ -193775,7 +295086,7 @@ synonym: "high rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000161 ! rate -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0000911 [Term] @@ -193783,9 +295094,11 @@ id: PATO:0000915 name: thickness namespace: quality def: "A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width." [WordNet:WordNet] +comment: Thickness often refers to the smallest 1-D extent compared to the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion. subset: attribute_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent +property_value: seeAlso https://github.com/pato-ontology/pato/issues/337 xsd:string [Term] id: PATO:0000918 @@ -193802,10 +295115,12 @@ id: PATO:0000921 name: width namespace: quality def: "A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite." [PATOC:GVG] +comment: Width often refers to the dimension that is greater than the extent in only one of the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion. subset: attribute_slim subset: scalar_slim synonym: "breadth" RELATED [] is_a: PATO:0001708 ! 1-D extent +property_value: seeAlso https://github.com/pato-ontology/pato/issues/337 xsd:string [Term] id: PATO:0000927 @@ -193907,10 +295222,21 @@ id: PATO:0000992 name: viscosity namespace: quality def: "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." [PATOC:GVG] +def: "A physical quality of a liquid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." [] subset: attribute_slim subset: disposition_slim is_a: PATO:0001548 ! quality of a liquid +[Term] +id: PATO:0000998 +name: viscous +namespace: quality +def: "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." [PATOC:GVG] +subset: disposition_slim +subset: mpath_slim +subset: value_slim +is_a: PATO:0000992 ! viscosity + [Term] id: PATO:0001018 name: physical quality @@ -193921,6 +295247,7 @@ subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001019 @@ -193988,6 +295315,15 @@ subset: value_slim is_a: PATO:0001031 ! elasticity property_value: RO:0002604 PATO:0001172 +[Term] +id: PATO:0001190 +name: juvenile +namespace: quality +def: "A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed." [thefreedictionary.com:thefreedictionary.com] +subset: mpath_slim +subset: value_slim +is_a: PATO:0000261 ! maturity + [Term] id: PATO:0001230 name: strength @@ -194029,7 +295365,9 @@ synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality +is_a: BFO:0000019 ! quality is_a: PATO:0000001 ! quality +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001291 @@ -194039,6 +295377,24 @@ def: "A physical quality that inheres in an bearer by virtue of how that bearer subset: attribute_slim is_a: PATO:0001739 ! radiation quality +[Term] +id: PATO:0001292 +name: full-spectrum EM radiation quality +def: "An EM radiation quality that is independent of the EM wavelength range." [] +is_a: PATO:0001291 ! electromagnetic (EM) radiation quality + +[Term] +id: PATO:0001294 +name: radiation reflective quality +def: "A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation." [] +is_a: PATO:0001292 ! full-spectrum EM radiation quality + +[Term] +id: PATO:0001297 +name: reflectivity +def: "A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface." [] +is_a: PATO:0001294 ! radiation reflective quality + [Term] id: PATO:0001300 name: optical quality @@ -194046,6 +295402,7 @@ namespace: quality def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001291 ! electromagnetic (EM) radiation quality +is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation [Term] id: PATO:0001301 @@ -194087,7 +295444,9 @@ synonym: "hot" EXACT [] is_a: PATO:0000146 ! temperature is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000146 ! temperature +intersection_of: PATO:0000146 ! temperature intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001306 [Term] @@ -194102,7 +295461,9 @@ synonym: "low temperature" EXACT [] is_a: PATO:0000146 ! temperature is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000146 ! temperature +intersection_of: PATO:0000146 ! temperature intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001305 [Term] @@ -194154,6 +295515,15 @@ def: "A cellular quality inhering in a bearer by virtue of the bearer's number o subset: attribute_slim is_a: PATO:0001396 ! cellular quality +[Term] +id: PATO:0001375 +name: haploid +namespace: quality +def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Haploid] +subset: cell_quality +subset: value_slim +is_a: PATO:0001393 ! euploid + [Term] id: PATO:0001393 name: euploid @@ -194163,12 +295533,18 @@ subset: cell_quality subset: value_slim is_a: PATO:0001374 ! ploidy +[Term] +id: PATO:0001394 +name: diploid +def: "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." [] +is_a: PATO:0001393 ! euploid + [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] -is_a: PATO:0001241 ! physical object quality +is_a: PATO:0070044 ! anatomical structure quality [Term] id: PATO:0001397 @@ -194391,7 +295767,9 @@ synonym: "shallow" EXACT [] is_a: PATO:0000587 ! decreased size is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth +intersection_of: PATO:0001595 ! depth intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001596 [Term] @@ -194404,7 +295782,9 @@ synonym: "high position" RELATED [] is_a: PATO:0000140 ! position is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000140 ! position +intersection_of: PATO:0000140 ! position intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001476 [Term] @@ -194417,7 +295797,9 @@ synonym: "low position" RELATED [] is_a: PATO:0000140 ! position is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000140 ! position +intersection_of: PATO:0000140 ! position intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001475 [Term] @@ -194448,6 +295830,13 @@ def: "A reproductive quality inhering in the young of an animal by virtue of the subset: attribute_slim is_a: PATO:0001434 ! reproductive quality +[Term] +id: PATO:0001501 +name: immature +def: "A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development." [] +synonym: "underdeveloped" RELATED [] +is_a: PATO:0000261 ! maturity + [Term] id: PATO:0001509 name: functionality @@ -194476,6 +295865,13 @@ subset: attribute_slim subset: disposition_slim is_a: PATO:0001546 ! quality of a solid +[Term] +id: PATO:0001544 +name: flexible +def: "A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking." [] +synonym: "bendy" EXACT [] +is_a: PATO:0001543 ! flexibility + [Term] id: PATO:0001546 name: quality of a solid @@ -194502,6 +295898,7 @@ def: "A physical quality inhering in an entity exhibiting the physical character subset: attribute_slim synonym: "liquidity" EXACT [] is_a: PATO:0002198 ! quality of a substance +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001551 @@ -194515,7 +295912,7 @@ synonym: "increased sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001457 ! sensitivity of a process -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001552 [Term] @@ -194530,7 +295927,7 @@ synonym: "low sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001457 ! sensitivity of a process -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001551 [Term] @@ -194549,6 +295946,7 @@ synonym: "number of" EXACT [] xref: OBO_REL:has_part is_a: PATO:0001241 ! physical object quality relationship: reciprocal_of PATO:0000070 ! amount +relationship: RO:0015012 PATO:0000070 ! reciprocal of amount [Term] id: PATO:0001559 @@ -194561,7 +295959,7 @@ synonym: "having supernumerary functions" EXACT [] is_a: PATO:0001509 ! functionality is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001509 ! functionality -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal [Term] id: PATO:0001562 @@ -194575,7 +295973,9 @@ synonym: "small mass" EXACT [] is_a: PATO:0000125 ! mass is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000125 ! mass +intersection_of: PATO:0000125 ! mass intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001563 [Term] @@ -194590,7 +295990,9 @@ synonym: "large mass" EXACT [] is_a: PATO:0000125 ! mass is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000125 ! mass +intersection_of: PATO:0000125 ! mass intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001562 [Term] @@ -194612,7 +296014,9 @@ synonym: "low pressure" EXACT [] is_a: PATO:0001025 ! pressure is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001025 ! pressure +intersection_of: PATO:0001025 ! pressure intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001576 [Term] @@ -194625,7 +296029,9 @@ synonym: "high pressure" EXACT [] is_a: PATO:0001025 ! pressure is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001025 ! pressure +intersection_of: PATO:0001025 ! pressure intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001575 [Term] @@ -194649,7 +296055,9 @@ synonym: "high contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001690 ! contractile +intersection_of: PATO:0001690 ! contractile intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001581 [Term] @@ -194663,7 +296071,9 @@ synonym: "low contractility" EXACT [] is_a: PATO:0001690 ! contractile is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001690 ! contractile +intersection_of: PATO:0001690 ! contractile intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001580 [Term] @@ -194685,6 +296095,34 @@ def: "A surface shape quality inhering in a bearer by virtue of the bearer's exh subset: attribute_slim is_a: PATO:0000052 ! shape +[Term] +id: PATO:0001592 +name: increased curvature +namespace: quality +def: "A curvature which is relatively high." [PATO:GVG] +subset: value_slim +is_a: PATO:0000406 ! curved +is_a: PATO:0002305 ! increased object quality +intersection_of: PATO:0000406 ! curved +intersection_of: PATO:0000406 ! curved +intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +property_value: RO:0002604 PATO:0001593 + +[Term] +id: PATO:0001593 +name: decreased curvature +namespace: quality +def: "A curvature which is relatively low." [PATO:GVG] +subset: value_slim +is_a: PATO:0000406 ! curved +is_a: PATO:0002303 ! decreased object quality +intersection_of: PATO:0000406 ! curved +intersection_of: PATO:0000406 ! curved +intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +property_value: RO:0002604 PATO:0001592 + [Term] id: PATO:0001595 name: depth @@ -194706,7 +296144,7 @@ synonym: "deep" EXACT [] is_a: PATO:0000586 ! increased size is_a: PATO:0001595 ! depth intersection_of: PATO:0001595 ! depth -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001472 [Term] @@ -194728,7 +296166,7 @@ synonym: "high life span" EXACT [] is_a: PATO:0000050 ! life span is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000050 ! life span -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001604 [Term] @@ -194740,7 +296178,7 @@ synonym: "low life span" EXACT [] is_a: PATO:0000050 ! life span is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000050 ! life span -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001603 [Term] @@ -194763,7 +296201,7 @@ synonym: "high tonicity" EXACT [] is_a: PATO:0001439 ! tonicity is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001439 ! tonicity -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001619 [Term] @@ -194777,7 +296215,7 @@ synonym: "low tonicity" EXACT [] is_a: PATO:0001439 ! tonicity is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001439 ! tonicity -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001618 [Term] @@ -194800,7 +296238,7 @@ synonym: "low turgor" EXACT [] is_a: PATO:0001620 ! turgor is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001620 ! turgor -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001622 [Term] @@ -194814,7 +296252,7 @@ synonym: "high turgor" EXACT [] is_a: PATO:0001620 ! turgor is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001620 ! turgor -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001621 [Term] @@ -194878,7 +296316,9 @@ synonym: "low osmolarity" EXACT [] is_a: PATO:0001655 ! osmolarity is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001655 ! osmolarity +intersection_of: PATO:0001655 ! osmolarity intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001657 [Term] @@ -194892,7 +296332,9 @@ synonym: "high osmolarity" EXACT [] is_a: PATO:0001655 ! osmolarity is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001655 ! osmolarity +intersection_of: PATO:0001655 ! osmolarity intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001656 [Term] @@ -194924,7 +296366,9 @@ synonym: "high elevation" EXACT [] is_a: PATO:0001475 ! increased position is_a: PATO:0001687 ! elevation intersection_of: PATO:0001687 ! elevation +intersection_of: PATO:0001687 ! elevation intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001689 [Term] @@ -194937,7 +296381,9 @@ synonym: "low elevation" EXACT [] is_a: PATO:0001476 ! decreased position is_a: PATO:0001687 ! elevation intersection_of: PATO:0001687 ! elevation +intersection_of: PATO:0001687 ! elevation intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001688 [Term] @@ -194951,6 +296397,38 @@ subset: value_slim is_a: PATO:0001579 ! contractility property_value: RO:0002604 PATO:0001691 +[Term] +id: PATO:0001693 +name: increased viscosity +namespace: quality +def: "A viscosity which relatively high." [PATOC:GVG] +subset: disposition_slim +subset: value_slim +synonym: "high viscosity" EXACT [] +is_a: PATO:0000998 ! viscous +is_a: PATO:0002305 ! increased object quality +intersection_of: PATO:0000998 ! viscous +intersection_of: PATO:0000998 ! viscous +intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +property_value: RO:0002604 PATO:0001694 + +[Term] +id: PATO:0001694 +name: decreased viscosity +namespace: quality +def: "A viscosity which relatively low." [PATOC:GVG] +subset: disposition_slim +subset: value_slim +synonym: "low viscosity" EXACT [] +is_a: PATO:0000998 ! viscous +is_a: PATO:0002303 ! decreased object quality +intersection_of: PATO:0000998 ! viscous +intersection_of: PATO:0000998 ! viscous +intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +property_value: RO:0002604 PATO:0001693 + [Term] id: PATO:0001695 name: increased fecundity @@ -194962,7 +296440,7 @@ synonym: "high fecundity" EXACT [] is_a: PATO:0000273 ! fecundity is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000273 ! fecundity -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001696 [Term] @@ -194976,7 +296454,7 @@ synonym: "low fecundity" EXACT [] is_a: PATO:0000273 ! fecundity is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000273 ! fecundity -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001695 [Term] @@ -195024,7 +296502,7 @@ subset: value_slim is_a: PATO:0000573 ! increased length is_a: PATO:0001711 ! perimeter intersection_of: PATO:0001711 ! perimeter -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001713 [Term] @@ -195036,7 +296514,7 @@ subset: value_slim is_a: PATO:0000574 ! decreased length is_a: PATO:0001711 ! perimeter intersection_of: PATO:0001711 ! perimeter -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001712 [Term] @@ -195048,7 +296526,7 @@ subset: value_slim is_a: PATO:0000586 ! increased size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001715 [Term] @@ -195060,7 +296538,7 @@ subset: value_slim is_a: PATO:0000587 ! decreased size is_a: PATO:0001334 ! diameter intersection_of: PATO:0001334 ! diameter -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001714 [Term] @@ -195098,6 +296576,26 @@ subset: mpath_slim subset: value_slim is_a: PATO:0001857 ! concave +[Term] +id: PATO:0001776 +name: increased flexibility +def: "A flexibility which is relatively high." [] +synonym: "high flexibility" EXACT [] +is_a: PATO:0001544 ! flexible +is_a: PATO:0002305 ! increased object quality +intersection_of: PATO:0001544 ! flexible +intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal + +[Term] +id: PATO:0001777 +name: decreased flexibility +def: "A flexibility which is relatively low." [] +synonym: "low flexibility" EXACT [] +is_a: PATO:0001544 ! flexible +is_a: PATO:0002303 ! decreased object quality +intersection_of: PATO:0001544 ! flexible +intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal + [Term] id: PATO:0001778 name: increased strength @@ -195108,7 +296606,7 @@ synonym: "high strength" EXACT [] is_a: PATO:0001230 ! strength is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001230 ! strength -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001779 [Term] @@ -195121,7 +296619,7 @@ synonym: "weak" EXACT [] is_a: PATO:0001230 ! strength is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001230 ! strength -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001778 [Term] @@ -195134,7 +296632,7 @@ synonym: "high intensity" EXACT [] is_a: PATO:0000049 ! intensity is_a: PATO:0002300 ! increased quality intersection_of: PATO:0000049 ! intensity -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001783 [Term] @@ -195147,9 +296645,19 @@ synonym: "low intensity" EXACT [] is_a: PATO:0000049 ! intensity is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0000049 ! intensity -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001782 +[Term] +id: PATO:0001789 +name: domed +namespace: quality +def: "A curvature quality inhering in a bearer by virtue of the bearer's having a shape resembling a dome." [PATOC:GVG] +subset: cell_quality +subset: mpath_slim +subset: value_slim +is_a: PATO:0000406 ! curved + [Term] id: PATO:0001794 name: coiling @@ -195178,7 +296686,7 @@ synonym: "dry" RELATED [] is_a: PATO:0001800 ! water composition is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001800 ! water composition -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal [Term] id: PATO:0001806 @@ -195201,7 +296709,7 @@ synonym: "low sensitivity to irradiation" EXACT [] is_a: PATO:0001806 ! sensitivity to irradiation is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001806 ! sensitivity to irradiation -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001808 [Term] @@ -195215,7 +296723,7 @@ synonym: "high sensitivity to irradiation" EXACT [] is_a: PATO:0001806 ! sensitivity to irradiation is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001806 ! sensitivity to irradiation -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001807 [Term] @@ -195258,7 +296766,7 @@ synonym: "low acidity" EXACT [] is_a: PATO:0001842 ! acidity is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001842 ! acidity -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001844 [Term] @@ -195271,7 +296779,7 @@ synonym: "high acidity" EXACT [] is_a: PATO:0001842 ! acidity is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001842 ! acidity -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001843 [Term] @@ -195284,6 +296792,12 @@ subset: value_slim is_a: PATO:0002005 ! concavity property_value: RO:0002604 PATO:0001355 +[Term] +id: PATO:0001863 +name: chronic +def: "A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration." [] +is_a: PATO:0001309 ! duration + [Term] id: PATO:0001873 name: cylindrical @@ -195297,6 +296811,15 @@ synonym: "rod-shaped" EXACT [] synonym: "tubulate" NARROW [] is_a: PATO:0002007 ! convex 3-D shape relationship: has_cross_section PATO:0000411 ! circular +relationship: RO:0015011 PATO:0000411 ! has cross section circular + +[Term] +id: PATO:0001874 +name: discoid +def: "A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter." [] +synonym: "disc-shaped" EXACT [] +synonym: "disk-shaped" EXACT [] +is_a: PATO:0001873 ! cylindrical [Term] id: PATO:0001894 @@ -195315,7 +296838,7 @@ subset: value_slim is_a: PATO:0001648 ! circumference is_a: PATO:0001712 ! increased perimeter intersection_of: PATO:0001648 ! circumference -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001899 [Term] @@ -195327,7 +296850,7 @@ subset: value_slim is_a: PATO:0001648 ! circumference is_a: PATO:0001713 ! decreased perimeter intersection_of: PATO:0001648 ! circumference -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001898 [Term] @@ -195347,6 +296870,14 @@ subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated +[Term] +id: PATO:0001910 +name: folded +namespace: quality +def: "A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part." [PATOC:cjm] +subset: value_slim +is_a: PATO:0001925 ! surface feature shape + [Term] id: PATO:0001925 name: surface feature shape @@ -195375,7 +296906,7 @@ synonym: "low variability of size" EXACT [] is_a: PATO:0001956 ! variability of size is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001956 ! variability of size -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0001958 [Term] @@ -195388,9 +296919,18 @@ synonym: "high variability of size" EXACT [] is_a: PATO:0001956 ! variability of size is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001956 ! variability of size -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0001957 +[Term] +id: PATO:0001987 +name: saccular +namespace: quality +def: "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." [PATOC:MAH] +subset: value_slim +synonym: "sacular" EXACT [] +is_a: PATO:0002014 ! structure, cavities + [Term] id: PATO:0001992 name: cellularity @@ -195431,7 +296971,9 @@ synonym: "subnumerary" RELATED [] is_a: PATO:0000467 ! present is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0000070 ! amount +intersection_of: PATO:0000070 ! amount intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0000470 [Term] @@ -195450,7 +296992,7 @@ synonym: "increased number of" EXACT [] is_a: PATO:0002083 ! altered number of is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002083 ! altered number of -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0002001 [Term] @@ -195481,6 +297023,7 @@ subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: has_cross_section PATO:0002006 ! 2-D shape +relationship: RO:0015011 PATO:0002006 ! has cross section 2-D shape property_value: RO:0002604 PATO:0002008 [Term] @@ -195492,6 +297035,13 @@ subset: attribute_slim subset: cell_quality is_a: PATO:0000052 ! shape +[Term] +id: PATO:0002011 +name: neoplastic +def: "A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells." [] +synonym: "tumorous" EXACT [] +is_a: PATO:0000141 ! structure + [Term] id: PATO:0002014 name: structure, cavities @@ -195509,7 +297059,7 @@ subset: attribute_slim subset: relational_slim subset: scalar_slim is_a: PATO:0000033 ! concentration of -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-01-27T10:53:11Z [Term] @@ -195523,8 +297073,8 @@ synonym: "low osmolality" EXACT [] is_a: PATO:0002027 ! osmolality is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0002027 ! osmolality -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002029 creation_date: 2009-01-27T10:55:33Z @@ -195539,8 +297089,8 @@ synonym: "high osmolality" EXACT [] is_a: PATO:0002027 ! osmolality is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002027 ! osmolality -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002028 creation_date: 2009-01-27T10:56:19Z @@ -195553,7 +297103,7 @@ subset: mpath_slim subset: relational_slim subset: value_slim is_a: PATO:0000140 ! position -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-02-01T02:06:20Z [Term] @@ -195564,7 +297114,7 @@ def: "A structural quality inhering in a bearer by virtue of the bearer exhibiti subset: attribute_slim subset: scalar_slim is_a: PATO:0000141 ! structure -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-02-03T11:13:19Z [Term] @@ -195586,7 +297136,7 @@ synonym: "dendriform" EXACT [] synonym: "dendroid" EXACT [] synonym: "dendroidal" EXACT [] is_a: PATO:0000402 ! branched -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-02-15T08:11:41Z [Term] @@ -195598,8 +297148,8 @@ synonym: "increased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000057 ! occurrence -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002052 creation_date: 2009-03-26T11:10:11Z @@ -195612,8 +297162,8 @@ synonym: "decreased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000057 ! occurrence -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002051 creation_date: 2009-03-26T11:12:35Z @@ -195626,8 +297176,8 @@ subset: value_slim is_a: PATO:0000586 ! increased size is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002058 creation_date: 2009-03-30T04:11:43Z @@ -195640,8 +297190,8 @@ subset: value_slim is_a: PATO:0000587 ! decreased size is_a: PATO:0001323 ! area intersection_of: PATO:0001323 ! area -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002057 creation_date: 2009-03-30T04:12:11Z @@ -195651,7 +297201,7 @@ name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X created_by: george creation_date: 2009-06-05T09:16:46Z @@ -195662,53 +297212,32 @@ namespace: quality def: "A spatial pattern inhering in a bearer by virtue of the bearer's layered configuration." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000060 ! spatial pattern -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-07-01T02:30:45Z [Term] id: PATO:0002070 name: affinity -namespace: quality -def: "A molecular quality that arises from the molecular attraction exerted between two atoms or compounds." [PATOC:GVG] -subset: attribute_slim -subset: disposition_slim -subset: relational_slim -subset: scalar_slim +def: "A molecular quality that arises from the molecular attraction exerted between two atoms or compounds." [] is_a: PATO:0002182 ! molecular quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X -creation_date: 2009-09-18T01:16:16Z [Term] id: PATO:0002071 name: increased affinity -namespace: quality -def: "An affinity which is relatively high." [PATOC:GVG] -subset: disposition_slim -subset: relational_slim -subset: value_slim +def: "An affinity which is relatively high." [] is_a: PATO:0002070 ! affinity is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002070 ! affinity intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X -property_value: RO:0002604 PATO:0002072 -creation_date: 2009-09-18T01:29:42Z [Term] id: PATO:0002072 name: decreased affinity -namespace: quality -def: "An affinity which is relatively low." [PATOC:GVG] -subset: disposition_slim -subset: relational_slim -subset: value_slim +def: "An affinity which is relatively low." [] is_a: PATO:0002070 ! affinity is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0002070 ! affinity intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X -property_value: RO:0002604 PATO:0002071 -creation_date: 2009-09-18T01:30:11Z [Term] id: PATO:0002076 @@ -195718,7 +297247,7 @@ def: "A behavioral quality inhering in a bearer by virtue of the bearer's moveme subset: attribute_slim synonym: "movement behavioural quality" EXACT [] is_a: PATO:0000186 ! behavioral quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-09-18T02:04:48Z [Term] @@ -195728,7 +297257,7 @@ namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." [url:http\://www.merriam-webster.com/dictionary/hollow] subset: value_slim is_a: PATO:0002014 ! structure, cavities -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-09-18T02:19:20Z [Term] @@ -195740,7 +297269,7 @@ subset: attribute_slim subset: relational_slim is_a: PATO:0000051 ! morphology is_a: PATO:0001555 ! has number of -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X created_by: George Gkoutos creation_date: 2009-09-21T10:41:58Z @@ -195748,14 +297277,31 @@ creation_date: 2009-09-21T10:41:58Z id: PATO:0002094 name: basophilic namespace: quality -def: "An affinity inhering in a tissue constituent by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG] +def: "An affinity inhering in a tissue constituent by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [] +def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG] subset: disposition_slim subset: mpath_slim subset: value_slim is_a: PATO:0002070 ! affinity -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +is_a: PATO:0070045 ! anatomical histological quality +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-05T12:05:23Z +[Term] +id: PATO:0002096 +name: neoplastic, non-malignant +def: "A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize." [] +synonym: "benign" RELATED [] +is_a: PATO:0002011 ! neoplastic +disjoint_from: PATO:0002097 ! neoplastic, malignant +disjoint_from: PATO:0002129 ! neoplastic, invasive + +[Term] +id: PATO:0002097 +name: neoplastic, malignant +def: "A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize." [] +is_a: PATO:0002011 ! neoplastic + [Term] id: PATO:0002107 name: peripheral @@ -195765,7 +297311,7 @@ subset: mpath_slim subset: relational_slim subset: value_slim is_a: PATO:0000140 ! position -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-05T02:58:16Z [Term] @@ -195776,9 +297322,15 @@ def: "A quality inhering in a bearer by virtue of the bearer's processing the fo subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2009-10-06T04:37:14Z +[Term] +id: PATO:0002129 +name: neoplastic, invasive +def: "A disposition inhering in a tumour by virtue of the bearer's disposition to invade surrounding tissues." [] +is_a: PATO:0002011 ! neoplastic + [Term] id: PATO:0002175 name: deviation @@ -195786,7 +297338,7 @@ namespace: quality def: "A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity." [PATO:GVG] subset: attribute_slim is_a: PATO:0000060 ! spatial pattern -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-02-25T09:14:42Z [Term] @@ -195796,7 +297348,7 @@ namespace: quality def: "A positional quality inhering in a bearer by virtue the bearer's being changed in position." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000140 ! position -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-01T02:56:33Z [Term] @@ -195807,7 +297359,7 @@ alt_id: PATO:0002061 def: "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." [PATOC:GVG] synonym: "relational molecular quality" EXACT [] is_a: PATO:0001241 ! physical object quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-10T03:18:15Z [Term] @@ -195818,7 +297370,7 @@ def: "A molecular quality that inheres in a molecular entity by virtue of whethe subset: attribute_slim subset: scalar_slim is_a: PATO:0002182 ! molecular quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-03-10T03:22:04Z [Term] @@ -195828,7 +297380,8 @@ namespace: quality def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001018 ! physical quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X +property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2010-03-15T04:35:27Z @@ -195839,7 +297392,7 @@ namespace: quality def: "A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical." [url:http\://www.thefreedictionary.com/Subcylindrical] subset: value_slim is_a: PATO:0001873 ! cylindrical -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-07-13T04:22:30Z [Term] @@ -195852,8 +297405,8 @@ synonym: "increased force amplitude" EXACT [] is_a: PATO:0001035 ! force is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001035 ! force -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002246 creation_date: 2010-08-04T11:12:20Z @@ -195867,8 +297420,8 @@ synonym: "decreased force amplitude" EXACT [] is_a: PATO:0001035 ! force is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001035 ! force -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002245 creation_date: 2010-08-04T11:13:13Z @@ -195880,8 +297433,8 @@ def: "A quality inhering in a bearer by virtue of the bearer's having or lacking subset: attribute_slim subset: scalar_slim is_a: PATO:0000141 ! structure +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X relationship: RO:0002610 PATO:0000014 ! correlated with color -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-08-09T04:14:00Z [Term] @@ -195893,7 +297446,7 @@ comment: Becoming flat but not necessarily completely flat. subset: value_slim synonym: "compressed" RELATED [] is_a: PATO:0001591 ! curvature -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-08-16T03:59:34Z [Term] @@ -195905,7 +297458,7 @@ subset: value_slim synonym: "channeled" RELATED [] synonym: "creased" RELATED [] is_a: PATO:0000150 ! texture -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-01T10:27:48Z [Term] @@ -195916,7 +297469,7 @@ def: "A spatial quality inhering in a bearer by virtue of the bearer's location subset: relational_slim subset: value_slim is_a: PATO:0000140 ! position -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-09T09:36:56Z [Term] @@ -195926,7 +297479,7 @@ namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's being arranged in a systematic fashion." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000141 ! structure -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-16T10:22:52Z [Term] @@ -195938,7 +297491,7 @@ subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0000186 ! behavioral quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-09-21T06:56:58Z [Term] @@ -195947,7 +297500,7 @@ name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2010-10-05T12:31:16Z [Term] @@ -195959,8 +297512,10 @@ subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001171 ! elastic +intersection_of: PATO:0001171 ! elastic intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002288 creation_date: 2011-03-30T11:50:21Z @@ -195973,8 +297528,10 @@ subset: value_slim is_a: PATO:0001171 ! elastic is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001171 ! elastic +intersection_of: PATO:0001171 ! elastic intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002287 creation_date: 2011-03-30T11:50:39Z @@ -195987,7 +297544,7 @@ subset: value_slim is_a: PATO:0001488 ! cellular motility is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001488 ! cellular motility -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0002298 [Term] @@ -195999,7 +297556,7 @@ subset: value_slim is_a: PATO:0001488 ! cellular motility is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001488 ! cellular motility -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0002297 [Term] @@ -196012,7 +297569,7 @@ synonym: "tube-shaped" EXACT [] synonym: "tubulate" EXACT [] is_a: PATO:0001873 ! cylindrical is_a: PATO:0002078 ! hollow -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-06-08T06:33:50Z [Term] @@ -196022,9 +297579,12 @@ namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality +intersection_of: PATO:0000001 ! quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal property_value: RO:0002604 PATO:0002301 creation_date: 2011-06-16T06:39:43Z @@ -196035,9 +297595,12 @@ namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation (from_normal) intersection_of: PATO:0000001 ! quality +intersection_of: PATO:0000001 ! quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal property_value: RO:0002604 PATO:0002300 created_by: George Gkoutos creation_date: 2011-06-16T06:40:15Z @@ -196050,8 +297613,10 @@ def: "A quality of a process that has a value that is decreased compared to norm is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality +intersection_of: PATO:0001236 ! process quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002304 created_by: George Gkoutos creation_date: 2011-06-16T06:50:59Z @@ -196064,8 +297629,10 @@ def: "A quality of an object that has a value that is decreased compared to norm is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality +intersection_of: PATO:0001241 ! physical object quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002305 created_by: George Gkoutos creation_date: 2011-06-16T06:51:54Z @@ -196078,8 +297645,10 @@ def: "A quality of a process that has a value that is increased compared to norm is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality +intersection_of: PATO:0001236 ! process quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002302 creation_date: 2011-06-16T06:53:08Z @@ -196091,8 +297660,10 @@ def: "A quality of an object that has a value that is increased compared to norm is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality +intersection_of: PATO:0001241 ! physical object quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002303 creation_date: 2011-06-16T06:54:01Z @@ -196104,7 +297675,7 @@ def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's comment: Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope). subset: value_slim is_a: PATO:0002226 ! subcylindrical -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-09-09T04:50:10Z [Term] @@ -196114,7 +297685,7 @@ namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-10-12T12:45:16Z [Term] @@ -196124,7 +297695,7 @@ namespace: quality def: "A temporal distribution pattern of process occurrences within a regulation/reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002062 ! physical quality of a process -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-22T01:12:28Z [Term] @@ -196135,7 +297706,7 @@ def: "The temporal relation between the start of the process with respect to a r subset: attribute_slim synonym: "initiation" RELATED [] is_a: PATO:0002323 ! temporal distribution quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-23T11:47:34Z [Term] @@ -196146,7 +297717,7 @@ def: "An orientation inhering in a bearer by virtue of the bearer's placement at subset: attribute_slim subset: relational_slim is_a: PATO:0000133 ! orientation -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2011-11-23T12:06:09Z [Term] @@ -196159,8 +297730,8 @@ subset: value_slim is_a: PATO:0001475 ! increased position is_a: PATO:0002326 ! angle intersection_of: PATO:0002326 ! angle -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002328 creation_date: 2011-11-23T12:06:38Z @@ -196174,11 +297745,22 @@ subset: value_slim is_a: PATO:0001476 ! decreased position is_a: PATO:0002326 ! angle intersection_of: PATO:0002326 ! angle -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X property_value: RO:0002604 PATO:0002327 creation_date: 2011-11-23T12:06:54Z +[Term] +id: PATO:0002418 +name: acidophilic +namespace: quality +def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." [PATOC:GVG] +subset: mpath_slim +subset: value_slim +is_a: PATO:0070045 ! anatomical histological quality +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X +creation_date: 2012-12-17T03:01:19Z + [Term] id: PATO:0002422 name: acinar @@ -196188,9 +297770,15 @@ comment: Acinus is Latin for berry. subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2012-12-17T03:11:10Z +[Term] +id: PATO:0002444 +name: mineralized +def: "A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material." [] +is_a: PATO:0000025 ! composition + [Term] id: PATO:0002462 name: collagenous @@ -196198,9 +297786,19 @@ namespace: quality def: "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." [PATOC:WD] subset: value_slim is_a: PATO:0000025 ! composition -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T11:34:15Z +[Term] +id: PATO:0002468 +name: distensible +namespace: quality +def: "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." [PATOC:WD] +subset: value_slim +is_a: PATO:0015008 ! distensibility +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X +creation_date: 2013-09-15T11:48:26Z + [Term] id: PATO:0002478 name: transversely striated @@ -196210,7 +297808,7 @@ subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001410 ! striated -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-09-15T12:29:15Z [Term] @@ -196221,9 +297819,21 @@ def: "A nucleate quality inhering in a bearer by virtue of the bearer's having o subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-2061-091X +relationship: dc-contributor https://orcid.org/0000-0002-2061-091X creation_date: 2013-10-21T05:44:34Z +[Term] +id: PATO:0002507 +name: keratinous +def: "A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin." [] +is_a: PATO:0000025 ! composition + +[Term] +id: PATO:0010001 +name: disconnected +def: "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." [] +is_a: PATO:0000141 ! structure + [Term] id: PATO:0010006 name: cell morphology @@ -196231,7 +297841,7 @@ namespace: quality def: "A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure." [ORCID:0000-0002-7073-9172] comment: Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts. is_a: PATO:0000051 ! morphology -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0002-7073-9172 +relationship: dc-contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2021-01-23T11:31:53Z [Term] @@ -196251,6 +297861,40 @@ def: "A quality inhering in a bearer by virtue of the degree to which the bearer subset: attribute_slim is_a: PATO:0000140 ! position +[Term] +id: PATO:0015008 +name: distensibility +namespace: quality +def: "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." [GOC:CJM] +subset: attribute_slim +is_a: PATO:0000141 ! structure + +[Term] +id: PATO:0015021 +name: combustibility +def: "The propensity of a material to undergo combustion. Combustion encompasses smouldering and flaming combustion. Combustibility is usually applied to solids." [] +is_a: PATO:0001018 ! physical quality + +[Term] +id: PATO:0015022 +name: increased combustibility +def: "An increase in combustibility." [] +synonym: "combustible" EXACT [] +is_a: PATO:0002305 ! increased object quality +is_a: PATO:0015021 ! combustibility +intersection_of: PATO:0015021 ! combustibility +intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal + +[Term] +id: PATO:0015023 +name: decreased combustibility +def: "An decrease in combustibility." [] +synonym: "noncombustible" RELATED [] +is_a: PATO:0002303 ! decreased object quality +is_a: PATO:0015021 ! combustibility +intersection_of: PATO:0015021 ! combustibility +intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal + [Term] id: PATO:0050000 name: rate of occurence @@ -196273,9 +297917,9 @@ def: "A rate of occurrence that is relatively high." [https://orcid.org/0000-000 is_a: PATO:0000912 ! increased rate is_a: PATO:0050000 ! rate of occurence intersection_of: PATO:0050000 ! rate of occurence -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0003-4148-4606 property_value: http://purl.org/dc/elements/1.1/date 2020-08-19T09:23:19Z xsd:dateTime -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-4148-4606 [Term] id: PATO:0055004 @@ -196285,9 +297929,9 @@ def: "A rate of occurrence that is relatively low." [https://orcid.org/0000-0003 is_a: PATO:0000911 ! decreased rate is_a: PATO:0050000 ! rate of occurence intersection_of: PATO:0050000 ! rate of occurence -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0003-4148-4606 property_value: http://purl.org/dc/elements/1.1/date 2020-08-19T09:24:35Z xsd:dateTime -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-4148-4606 [Term] id: PATO:0055005 @@ -196297,9 +297941,9 @@ def: "A rate of output of a continuous process that is relatively high." [https: is_a: PATO:0000912 ! increased rate is_a: PATO:0050001 ! rate of continuous process intersection_of: PATO:0050001 ! rate of continuous process -intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0003-4148-4606 property_value: http://purl.org/dc/elements/1.1/date 2020-08-19T09:24:56Z xsd:dateTime -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-4148-4606 [Term] id: PATO:0055006 @@ -196309,21 +297953,35 @@ def: "A rate of output of a continuous process that is relatively low." [https:/ is_a: PATO:0000911 ! decreased rate is_a: PATO:0050001 ! rate of continuous process intersection_of: PATO:0050001 ! rate of continuous process -intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal +intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal +relationship: dc-contributor https://orcid.org/0000-0003-4148-4606 property_value: http://purl.org/dc/elements/1.1/date 2020-08-19T09:25:07Z xsd:dateTime -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0003-4148-4606 + +[Term] +id: PATO:0070002 +name: basket cell morphology +def: "A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells." [] +is_a: PATO:0070026 ! multipolar neuron morphology [Term] id: PATO:0070006 +name: bipolar morphology name: cortical bipolar morphology namespace: quality def: "A cell morphology that inheres in neurons which have two principal dendrites that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." [doi:10.1016/b978-0-12-369497-3.10004-4, PMID:18568015] +def: "A cell morphology that inheres in neurons which have two principal fibres (dendrites or axon) that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma." [] comment: This is specific to cortical bipolar cells and are distinguished from retinal bipolar cell morphology which has an axon and dendrite emerging from opposite ends of the soma. xref: ILX:0101312 xref: ilxtr:BipolarPhenotype xref: nifext:2 is_a: PATO:0070027 ! bitufted dendrite cell morphology -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-7258-9596 +relationship: dc-contributor https://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070026 +name: multipolar neuron morphology +def: "A cell morphology that inheres in neurons which possess a single axon and many dendrites and dendritic branches." [] +is_a: PATO:0010006 ! cell morphology [Term] id: PATO:0070027 @@ -196332,7 +297990,84 @@ namespace: quality def: "A cell morphology that inheres in neurons with dendrites that are bidirectional, emerging from opposite ends of the soma, with the two arbors extending in radial or tangential directions." [PMID:18568015] comment: This morphology type is distinct from bitufted cell morphology in that it refers to bitufted dendrite morphology rather than bitufted cell morphology. is_a: PATO:0010006 ! cell morphology -property_value: http://purl.org/dc/terms/contributor https://orcid.org/0000-0001-7258-9596 +relationship: dc-contributor https://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070044 +name: anatomical structure quality +namespace: quality +def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." [] +is_a: PATO:0001241 ! physical object quality +created_by: http://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070045 +name: anatomical histological quality +namespace: quality +def: "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." [] +is_a: PATO:0070044 ! anatomical structure quality +created_by: http://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070046 +name: neutrophillic +namespace: quality +def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." [GOC:add] +is_a: PATO:0070045 ! anatomical histological quality +created_by: http://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070047 +name: polychromatophilic +namespace: quality +def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." [GOC:add] +is_a: PATO:0070045 ! anatomical histological quality +created_by: http://orcid.org/0000-0001-7258-9596 + +[Term] +id: PATO:0070060 +name: quality of interaction of a substance with electromagnetic radiation +namespace: quality +def: "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." [https://orcid.org/0000-0002-5111-7263] +subset: attribute_slim +is_a: PATO:0002198 ! quality of a substance + +[Term] +id: PCO:0000000 +name: collection of organisms +def: "A material entity that consists of two or more organisms, viruses, or viroids." [] +is_a: PCO:0000031 ! organismal entity + +[Term] +id: PCO:0000001 +name: population of organisms +def: "A collection of organisms, all of the same species, that live in the same place." [] +is_a: CARO:0001010 ! organism or virus or viroid +is_a: PCO:0000018 ! single-species collection of organisms +relationship: RO:0002303 ENVO:01000739 ! has habitat habitat + +[Term] +id: PCO:0000002 +name: ecological community +def: "A multi-species collection of organisms of at least two different species, living in a particular area. Must have at least two populations of different species as members." [] +is_a: PCO:0000029 ! multi-species collection of organisms + +[Term] +id: PCO:0000018 +name: single-species collection of organisms +def: "A material entity that has as parts two or more organisms, viruses, or viroids of the same species and no members of any other species." [] +is_a: PCO:0000000 ! collection of organisms + +[Term] +id: PCO:0000029 +name: multi-species collection of organisms +def: "A collection of organisms that consists of two or more organisms from at least two species." [] +is_a: PCO:0000000 ! collection of organisms + +[Term] +id: PCO:0000031 +name: organismal entity +def: "A material entity that is one or more organisms, viruses or viroids." [] [Term] id: PO:0000003 @@ -196367,7 +298102,9 @@ synonym: "woody clump (narrow)" NARROW [FNA:c1ccca7d-2a98-4a9d-8603-c34b551935e0 synonym: "植物体全体 (Japanese, exact)" EXACT Japanese [NIG:Yukiko_Yamazaki] xref: PO_GIT:538 xref: PO_GIT:69 +is_a: FOODON:03411564 ! food product organismal source is_a: PO:0009011 ! plant structure +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl [Term] id: PO:0000015 @@ -196676,7 +298413,9 @@ subset: TraitNet synonym: "estructura vegetal (Spanish, exact)" EXACT Spanish [POC:Maria_Alejandra_Gandolfo] synonym: "植物 構造 (Japanese, exact)" EXACT Japanese [NIG:Yukiko_Yamazaki] xref: PO_GIT:57 +is_a: FOODON:03420116 ! part of organism is_a: PO:0025131 ! plant anatomical entity +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl [Term] id: PO:0009012 @@ -197043,6 +298782,7 @@ synonym: "植物 解剖学（形態）的実体 (Japanese, exact)" EXACT Japanes xref: PO_GIT:224 is_a: BFO:0000040 ! material entity relationship: only_in_taxon NCBITaxon:33090 {source="cjm"} ! Viridiplantae +property_value: IAO:0000412 http://purl.obolibrary.org/obo/po.owl created_by: rwalls creation_date: 2010-11-15T11:41:38Z @@ -197349,7 +299089,7 @@ name: receptor-type tyrosine-protein phosphatase C namespace: protein def: "A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule." [PMID:1351092, PRO:CNA] comment: Category=gene. Requested by=CL. -synonym: "CD45" EXACT [] +synonym: "CD45" RELATED Gene-based [] synonym: "L-CA" EXACT [] synonym: "leukocyte common antigen" EXACT [] synonym: "ly-5" EXACT [] @@ -197399,7 +299139,7 @@ is_a: PR:000001005 ! integrin alpha with A domain id: PR:000001014 name: receptor-type tyrosine-protein phosphatase C isoform CD45RABC namespace: protein -def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] +def: "A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] comment: Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exons 4(A), 5(B), and 6(C). synonym: "B220" RELATED [] synonym: "CD45R" RELATED [] @@ -197411,7 +299151,7 @@ is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C id: PR:000001015 name: receptor-type tyrosine-protein phosphatase C isoform CD45RA namespace: protein -def: "A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] +def: "A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof." [PMID:1351092, PRO:CNA, PRO:DAN] comment: Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C). synonym: "CD45RA" EXACT [] synonym: "PTPRC/iso:CD45RA" EXACT PRO-short-label [PRO:DNx] @@ -197581,7 +299321,7 @@ synonym: "B-cell surface antigen CD20" EXACT [] synonym: "B-lymphocyte antigen CD20" EXACT [] synonym: "B-lymphocyte surface antigen B1" EXACT [] synonym: "Bp35" EXACT [] -synonym: "CD20" EXACT [] +synonym: "CD20" RELATED Gene-based [] synonym: "leukocyte surface antigen Leu-16" EXACT [] synonym: "Ly-44" RELATED Gene-based [] synonym: "lymphocyte antigen 44" EXACT [] @@ -197989,8 +299729,9 @@ is_a: PR:000001785 ! prominin id: PR:000001809 name: CD59-like glycoprotein namespace: protein -def: "A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof. This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues." [PRO:WCB] -comment: Category=gene. Requested by=CL. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). +def: "A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof." [PRO:WCB] +comment: Category=gene. Requested by=CL. Pro-orthology refers to, in this case, after-speciation gene duplication in the non-human species (aka 1:many orthology). This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues. +synonym: "CD59-like" EXACT PRO-short-label [PRO:DNx] xref: PIRSF:PIRSF038782 is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein @@ -198166,7 +299907,7 @@ namespace: protein def: "A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "B-cell differentiation antigen LP-3" EXACT [] -synonym: "CD43" EXACT [] +synonym: "CD43" RELATED Gene-based [] synonym: "galactoglycoprotein" EXACT [] synonym: "GALGP" EXACT [] synonym: "leukocyte sialoglycoprotein" EXACT [] @@ -198294,7 +300035,7 @@ synonym: "TfR" EXACT [] synonym: "TfR1" EXACT [] synonym: "TFRC" EXACT PRO-short-label [PRO:DNx] synonym: "TR" RELATED [] -synonym: "Trfr" EXACT [] +synonym: "Trfr" RELATED Gene-based [] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein @@ -198348,7 +300089,7 @@ name: receptor-type tyrosine-protein kinase FLT3 namespace: protein def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. -synonym: "CD135" EXACT [] +synonym: "CD135" RELATED Gene-based [] synonym: "fetal liver kinase 2" EXACT [] synonym: "FL cytokine receptor" EXACT [] synonym: "FLK-2" EXACT [] @@ -198394,7 +300135,7 @@ comment: Category=gene. Requested by=CL. synonym: "CD117" EXACT [] synonym: "KIT" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-Kit" EXACT [] -synonym: "SCFR" EXACT [] +synonym: "SCFR" RELATED Gene-based [] synonym: "Sl" RELATED Gene-based [] synonym: "tyrosine-protein kinase Kit" EXACT [] xref: IUPHARobj:1805 @@ -198595,6 +300336,21 @@ synonym: "epoetin" EXACT [] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein +[Term] +id: PR:000007499 +name: fibroblast growth factor 8 +namespace: protein +def: "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." [PRO:DNx] +comment: Category=gene. +synonym: "AIGF" RELATED Gene-based [] +synonym: "androgen-induced growth factor" EXACT [] +synonym: "FGF-8" EXACT [] +synonym: "FGF8" EXACT PRO-short-label [PRO:DNx] +synonym: "HBGF-8" RELATED [] +synonym: "heparin-binding growth factor 8" RELATED [] +is_a: CHEBI:36080 ! protein +is_a: PR:000000001 ! protein + [Term] id: PR:000007581 name: fibronectin @@ -198610,7 +300366,7 @@ is_a: PR:000000001 ! protein [Term] id: PR:000007597 -name: proto-oncogene c-Fos +name: protein c-Fos namespace: protein def: "A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. Requested by=CL. @@ -198619,6 +300375,7 @@ synonym: "FOS" EXACT PRO-short-label [PRO:DNx] synonym: "G0/G1 switch regulatory protein 7" EXACT [] synonym: "G0S7" RELATED Gene-based [] synonym: "proto-oncogene protein c-fos" EXACT [] +synonym: "transcription factor AP-1 subunit c-Fos" EXACT [] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein @@ -198878,7 +300635,7 @@ synonym: "PRO1400" RELATED Gene-based [] synonym: "siderophilin" EXACT [] synonym: "TF" EXACT PRO-short-label [PRO:DNx] synonym: "transferrin" EXACT [] -synonym: "Trf" RELATED [] +synonym: "Trf" RELATED Gene-based [] is_a: CHEBI:36080 ! protein is_a: PR:000000001 ! protein @@ -199459,6 +301216,7 @@ name: integrin alpha lacking A domain namespace: protein def: "An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains." [PRO:DAN] comment: Category=family. +synonym: "fam:ITGAsansA" EXACT PRO-short-label [PRO:DAN] xref: PIRSF:PIRSF005666 is_a: PR:000025796 ! integrin alpha @@ -199665,17 +301423,19 @@ intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:P01101 -name: proto-oncogene c-Fos (mouse) +name: protein c-Fos (mouse) namespace: protein -def: "A proto-oncogene c-Fos that is encoded in the genome of mouse." [OMA:P01101, PRO:DNx] +def: "A protein c-Fos that is encoded in the genome of mouse." [OMA:P01101, PRO:DNx] comment: Category=organism-gene. synonym: "cellular oncogene fos (mouse)" EXACT [UniProtKB:P01101] +synonym: "FBJ osteosarcoma oncogene (mouse)" EXACT [UniProtKB:P01101] synonym: "Fos" RELATED Gene-based [UniProtKB:P01101] synonym: "mFOS" EXACT PRO-short-label [PRO:DNx] +synonym: "transcription factor AP-1 subunit c-Fos (mouse)" EXACT [UniProtKB:P01101] xref: UniProtKB:P01101 -is_a: PR:000007597 ! proto-oncogene c-Fos +is_a: PR:000007597 ! protein c-Fos is_a: PR:000029032 ! Mus musculus protein -intersection_of: PR:000007597 ! proto-oncogene c-Fos +intersection_of: PR:000007597 ! protein c-Fos intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] @@ -199756,7 +301516,7 @@ intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus id: PR:P05555 name: integrin alpha-M (mouse) namespace: protein -def: "An integrin alpha-M that is encoded in the genome of mouse." [OMA:P05555, PRO:DNx] +def: "An integrin alpha-M that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P05555] comment: Category=organism-gene. synonym: "CD11 antigen-like family member B (mouse)" EXACT [UniProtKB:P05555] synonym: "CD11b (mouse)" EXACT [UniProtKB:P05555] @@ -199788,6 +301548,26 @@ is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000001004 ! CD4 molecule intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus +[Term] +id: PR:P06800 +name: receptor-type tyrosine-protein phosphatase C (mouse) +namespace: protein +def: "A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of mouse." [OMA:P06800, PRO:DNx] +comment: Category=organism-gene. +synonym: "CD45 (mouse)" EXACT [UniProtKB:P06800] +synonym: "L-CA (mouse)" EXACT [UniProtKB:P06800] +synonym: "leukocyte common antigen (mouse)" EXACT [UniProtKB:P06800] +synonym: "Ly-5" RELATED Gene-based [UniProtKB:P06800] +synonym: "lymphocyte antigen 5 (mouse)" EXACT [UniProtKB:P06800] +synonym: "mPTPRC" EXACT PRO-short-label [PRO:DNx] +synonym: "Ptprc" RELATED Gene-based [UniProtKB:P06800] +synonym: "T200 (mouse)" EXACT [UniProtKB:P06800] +xref: UniProtKB:P06800 +is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C +is_a: PR:000029032 ! Mus musculus protein +intersection_of: PR:000001006 ! receptor-type tyrosine-protein phosphatase C +intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus + [Term] id: PR:P08071 name: lactotransferrin (mouse) @@ -200231,6 +302011,26 @@ is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus +[Term] +id: PR:P37237 +name: fibroblast growth factor 8 (mouse) +namespace: protein +def: "A fibroblast growth factor 8 that is encoded in the genome of mouse." [OMA:P37237, PRO:DNx] +comment: Category=organism-gene. +synonym: "Aigf" RELATED Gene-based [UniProtKB:P37237] +synonym: "AIGF (mouse)" EXACT [UniProtKB:P37237] +synonym: "androgen-induced growth factor (mouse)" EXACT [UniProtKB:P37237] +synonym: "FGF-8 (mouse)" EXACT [UniProtKB:P37237] +synonym: "Fgf8" RELATED Gene-based [UniProtKB:P37237] +synonym: "HBGF-8 (mouse)" RELATED [UniProtKB:P37237] +synonym: "heparin-binding growth factor 8 (mouse)" RELATED [UniProtKB:P37237] +synonym: "mFGF8" EXACT PRO-short-label [PRO:DNx] +xref: UniProtKB:P37237 +is_a: PR:000007499 ! fibroblast growth factor 8 +is_a: PR:000029032 ! Mus musculus protein +intersection_of: PR:000007499 ! fibroblast growth factor 8 +intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus + [Term] id: PR:P50283 name: T-cell antigen CD7 (mouse) @@ -200464,7 +302264,7 @@ intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus id: PR:Q63994 name: myeloid cell surface antigen CD33 (mouse) namespace: protein -def: "A CD33 molecule that is encoded in the genome of mouse." [OMA:Q63994, PRO:DNx] +def: "A CD33 molecule that is encoded in the genome of mouse." [PRO:WCB] comment: Category=organism-gene. synonym: "Cd33" RELATED Gene-based [UniProtKB:Q63994] synonym: "CD33 (mouse)" EXACT [UniProtKB:Q63994] @@ -200562,6 +302362,12 @@ is_a: PR:000029032 ! Mus musculus protein intersection_of: PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus +[Term] +id: RO:0002310 +name: exposure event or process +def: "A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism." [] +is_a: BFO:0000015 ! process + [Term] id: RO:0002577 name: system @@ -200797,6 +302603,10 @@ subset: SOFA synonym: "gene group" EXACT [] is_a: SO:0001411 ! biological_region +[Term] +id: Subset +is_a: IAO:0000102 ! data about an ontology part + [Term] id: UBERON:0000000 name: processual entity @@ -200811,6 +302621,7 @@ name: uterine cervix namespace: uberon def: "Lower, narrow portion of the uterus where it joins with the top end of the vagina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cervix] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "canalis cervicis uteri" EXACT LATIN [FMA:17740, FMA:TA] @@ -200843,7 +302654,13 @@ xref: Wikipedia:Cervix is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: continuous_with UBERON:0000996 ! vagina +intersection_of: part_of UBERON:0000995 ! uterus +relationship: continuous_with UBERON:0000996 ! vagina +relationship: contributes_to_morphology_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001359", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/uterine+cervix"} property_value: UBPROP:0000003 "The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001359", ontology="VHOG", source="DOI:10.1098/rspb.2004.2848 Lynch VJ, Roth JJ, Takahashi K, Dunn CW, Nonaka DF, Stopper GF, Wagner GP, Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals. Proceedings of the Royal Society of London, Series B (2004)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "cervical" xsd:string @@ -200864,6 +302681,11 @@ xref: MA:0000282 xref: SCTID:272650008 xref: VHOG:0000663 is_a: UBERON:0000161 ! orifice +intersection_of: UBERON:0000161 ! orifice +intersection_of: connects UBERON:0001707 ! nasal cavity +intersection_of: part_of UBERON:0005725 ! olfactory system +relationship: connects UBERON:0001707 ! nasal cavity +relationship: only_in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0000033 {source="ZFA"} ! head relationship: part_of UBERON:0005725 ! olfactory system property_value: UBPROP:0000001 "One of paired external openings of the nasal chamber.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000311", ontology="AAO", source="AAO:EJS"} @@ -200908,11 +302730,17 @@ xref: TAO:0000047 xref: UMLS:C0028429 {source="ncithesaurus:Nose"} xref: Wikipedia:Nose xref: ZFA:0000047 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0002268 ! olfactory organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: capable_of_part_of GO:0007608 ! sensory perception of smell +relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system +relationship: contributes_to_morphology_of UBERON:0001456 ! face relationship: develops_from UBERON:0003050 {source="ZFA"} ! olfactory placode +relationship: has_skeleton UBERON:0006813 ! nasal skeleton +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001456 {source="FMA", source="ZFA-def"} ! face property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg xsd:anyURI property_value: UBPROP:0000001 "a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]." xsd:string {source="Wikipedia:Nose"} @@ -200942,6 +302770,7 @@ name: islet of Langerhans namespace: uberon def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "island of Langerhans" RELATED [BTO:0000991] @@ -200968,8 +302797,14 @@ xref: Wikipedia:Islets_of_Langerhans xref: XAO:0000159 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0034922 ! cell cluster +relationship: contributes_to_morphology_of UBERON:0000016 ! endocrine pancreas +relationship: has_part CL:0000168 {source="PMID:16417468"} ! insulin secreting cell +relationship: has_part CL:0000172 {source="PMID:16417468"} ! somatostatin secreting cell +relationship: has_part CL:0000696 {gci_filler="NCBITaxon:117570", gci_relation="part_of", source="PMID:16417468"} ! PP cell +relationship: has_part CL:0002067 {source="PMID:16417468"} ! type A enteroendocrine cell relationship: part_of UBERON:0000016 ! endocrine pancreas property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010406", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000646", ontology="VHOG", source="PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" xsd:string {source="PMID:16417468"} @@ -201009,12 +302844,12 @@ xref: EV:0100132 xref: FMA:13889 xref: GAID:457 xref: HBA:4634 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=399 {source="BIRNLEX:1353"} xref: MA:0000176 xref: MAT:0000077 xref: MESH:D010902 xref: MIAA:0000077 xref: NCIT:C12399 +xref: neuronames:399 {source="BIRNLEX:1353"} xref: OpenCyc:Mx4rv6NQYJwpEbGdrcN5Y29ycA xref: SCTID:181125003 xref: TAO:0000118 @@ -201026,7 +302861,13 @@ xref: XAO:0000017 xref: ZFA:0000118 is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010133 ! neuroendocrine gland -relationship: immediate_transformation_of UBERON:0034875 {source="BGEE:ANN"} ! future pituitary gland +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: capable_of_part_of GO:0007276 ! gamete generation +relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon +relationship: has_part UBERON:0002196 ! adenohypophysis +relationship: has_part UBERON:0002198 ! neurohypophysis +relationship: immediate_transformation_of UBERON:0034875 {source="https://orcid.org/0000-0003-3308-6245"} ! future pituitary gland +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png xsd:anyURI property_value: UBPROP:0000001 "An endocrine gland derived from infundibulum of the floor of the diencephalon and an ectodermal dorsal protrusion from the buccal cavity which controls the secretion of many hormones influencing the function of various organs of the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010536", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000118", ontology="TAO", source="ZFIN:curator"} @@ -201058,7 +302899,6 @@ xref: NCIT:C13167 xref: SCTID:68439008 xref: UMLS:C0225344 {source="ncithesaurus:Submucosa"} xref: Wikipedia:Submucosa -is_a: BFO:0000040 ! material entity is_a: UBERON:0004923 ! organ component layer relationship: composed_primarily_of UBERON:0002384 ! connective tissue relationship: immediately_deep_to UBERON:0000344 ! mucosa @@ -201074,6 +302914,7 @@ namespace: uberon def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422] subset: cumbo subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -201106,6 +302947,7 @@ xref: MAT:0000338 xref: MESH:D017933 xref: MIAA:0000338 xref: NCIT:C12465 +xref: neuronames:3232 xref: SCTID:362292005 xref: TAO:0000142 xref: UMLS:C0206417 {source="ncithesaurus:Peripheral_Nervous_System"} @@ -201119,7 +302961,7 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: part_of UBERON:0001016 ! nervous system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png xsd:anyURI -property_value: RO:0002171 UBERON:0001017 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000142", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000429", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"} @@ -201299,6 +303141,7 @@ name: endocrine pancreas namespace: uberon def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -201322,10 +303165,16 @@ xref: Wikipedia:Islets_of_Langerhans xref: ZFA:0001260 is_a: UBERON:0000471 {source="ZFA"} ! compound organ component is_a: UBERON:0004119 ! endoderm-derived structure +relationship: capable_of GO:0030073 {source="GO"} ! insulin secretion +relationship: capable_of GO:0070091 {source="GO"} ! glucagon secretion +relationship: capable_of GO:0070253 {source="GO"} ! somatostatin secretion +relationship: composed_primarily_of UBERON:0000006 ! islet of Langerhans +relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas relationship: develops_from UBERON:0003923 ! dorsal pancreatic bud relationship: part_of UBERON:0000949 {source="AAO", source="FMA", source="XAO"} ! endocrine system relationship: part_of UBERON:0001264 ! pancreas property_value: editor_note "create a separate class for distributed pancreas, eg cyclostomes?" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"} property_value: UBPROP:0000001 "The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001260", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} @@ -201336,6 +303185,7 @@ id: UBERON:0000017 name: exocrine pancreas namespace: uberon def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -201351,6 +303201,7 @@ xref: EMAPA:35328 xref: EV:0100093 xref: FMA:16017 xref: MA:0002415 +xref: MESH:D046790 xref: NCIT:C32546 xref: SCTID:248202004 xref: TAO:0001249 @@ -201362,8 +303213,13 @@ xref: ZFA:0001249 is_a: UBERON:0000409 ! serous gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005177 ! trunk region element +relationship: capable_of_part_of GO:0007586 ! digestion +relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas relationship: develops_from UBERON:0003924 ! ventral pancreatic bud +relationship: has_part UBERON:0001263 ! pancreatic acinus +relationship: has_part UBERON:0007329 ! pancreatic duct relationship: part_of UBERON:0001264 ! pancreas +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001249", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} @@ -201500,7 +303356,9 @@ synonym: "skin appendage" EXACT [FMA:71012] xref: CALOHA:TS-0051 xref: FMA:71012 xref: SCTID:276160000 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0013703 ! integumentary projection +relationship: attaches_to UBERON:0002097 ! skin of body property_value: editor_note "Mammary glands develop by similar mechanisms, and there is an argument for including them here (e.g. http://www.ncbi.nlm.nih.gov/pubmed/20484386), but these structures do not fit the current definition (lactiferous glands are part of the integumentary system in FMA). Note the FMA class is a subdivision of epidermis, which may be too restrictive for our purposes here." xsd:string [Term] @@ -201522,6 +303380,7 @@ is_a: UBERON:0000021 ! cutaneous appendage is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0001003 ! skin epidermis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/41/Parts_of_feather_modified.jpg xsd:anyURI +property_value: RO:0002161 NCBITaxon:314146 property_value: seeAlso http://xkcd.com/1104/ xsd:anyURI property_value: UBPROP:0000008 "Among the characteristics that distinguish the extant Aves from other living groups. Feathers have also been noticed in those Theropoda which have been termed feathered dinosaurs. Although feathers cover most parts of the body of birds, they arise only from certain well-defined tracts on the skin. They aid in flight, thermal insulation, waterproofing and coloration that helps in communication and protection" xsd:string property_value: UBPROP:0000010 "The beta-keratins in feathers, beaks and claws - and the claws, scales and shells of reptiles - are composed of protein strands hydrogen-bonded into beta-pleated sheets, which are then further twisted and crosslinked by disulfide bridges into structures even tougher than the alpha-keratins of mammalian hair, horns and hoof." xsd:string @@ -201620,6 +303479,7 @@ name: lymph node namespace: uberon def: "Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph." [BTO:0000784] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -201647,11 +303507,20 @@ xref: Wikipedia:Lymph_node xref: ZFA_RETIRED:0005318 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005057 ! immune organ +intersection_of: UBERON:0000062 ! organ +intersection_of: composed_primarily_of UBERON:0001744 ! lymphoid tissue +intersection_of: continuous_with UBERON:0001473 ! lymphatic vessel +relationship: composed_primarily_of UBERON:0001744 ! lymphoid tissue +relationship: continuous_with UBERON:0001473 ! lymphatic vessel relationship: develops_from UBERON:0034953 ! embryonic lymph sac +relationship: has_part UBERON:0002006 ! cortex of lymph node +relationship: has_part UBERON:0002007 ! medulla of lymph node +relationship: has_part UBERON:0002194 ! capsule of lymph node +relationship: has_part UBERON:0002391 ! lymph +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of UBERON:0002465 ! lymphoid system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png xsd:anyURI -property_value: RO:0002161 NCBITaxon:32443 {source="DOI:10.1177/0192623311409597", source="ZFA:0005318"} -property_value: RO:0002161 NCBITaxon:8570 {source="Wikipedia"} +property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/650 xsd:anyURI property_value: UBPROP:0000003 "Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001273", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.630", source="http://bgee.unil.ch/"} @@ -201674,12 +303543,12 @@ xref: NCIT:C32918 xref: SCTID:298225002 xref: UMLS:C1179187 {source="ncithesaurus:Lamina_Propria"} xref: Wikipedia:Lamina_propria -is_a: BFO:0000040 ! material entity is_a: UBERON:0004923 ! organ component layer relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue relationship: immediately_deep_to UBERON:0000483 ! epithelium relationship: part_of UBERON:0000344 ! mucosa property_value: depicted:by GI:Organization.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg xsd:anyURI [Term] id: UBERON:0000031 @@ -201771,6 +303640,7 @@ id: UBERON:0000035 name: primary ovarian follicle namespace: uberon def: "An ovarian follicle that has one layer of granulosa cells." [GO:0001545, GOC:mtg_mpo, http://ovary.stanford.edu] +subset: human_reference_atlas subset: pheno_slim synonym: "folliculus ovaricus primarius" EXACT LATIN [FMA:18634] synonym: "ovary primary follicle" EXACT [MA:0002907] @@ -201787,12 +303657,14 @@ xref: MA:0002907 xref: SCTID:258665002 is_a: UBERON:0001305 ! ovarian follicle relationship: develops_from UBERON:0003981 ! primordial ovarian follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000036 name: secondary ovarian follicle namespace: uberon def: "A maturing ovarian follicle that has two more more layers of granulosa cells, up to the onset of antrum formation." [GO:0001546, http://ovary.stanford.edu, http://www.repropedia.org/secondary-ovarian-follicle] +subset: human_reference_atlas subset: pheno_slim synonym: "antral follicle of ovary" RELATED [FMA:18637] synonym: "folliculus ovaricus secondarius" EXACT [] @@ -201809,6 +303681,7 @@ xref: MA:0002908 is_a: UBERON:0001305 ! ovarian follicle relationship: develops_from UBERON:0000035 ! primary ovarian follicle property_value: editor_note "consider adopting distinction in MA" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000037 @@ -201837,7 +303710,30 @@ xref: SCTID:362261008 xref: UMLS:C0600225 {source="ncithesaurus:Graafian_Follicle"} is_a: UBERON:0001305 ! ovarian follicle relationship: develops_from UBERON:0000036 ! secondary ovarian follicle -property_value: depicted:by Primary:follicle-4.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG xsd:anyURI + +[Term] +id: UBERON:0000038 +name: follicular fluid +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000463 ! organism substance +relationship: has_part CHEBI:17089 ! glycoprotein +relationship: has_part UBERON:0000456 ! secretion of exocrine gland +relationship: has_part UBERON:0007779 ! transudate +relationship: located_in UBERON:0000039 ! follicular antrum +relationship: part_of UBERON:0001305 ! ovarian follicle +relationship: surrounds CL:0000025 ! egg cell + +[Term] +id: UBERON:0000039 +name: follicular antrum +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: location_of UBERON:0000038 ! follicular fluid +intersection_of: part_of UBERON:0001305 ! ovarian follicle +relationship: location_of UBERON:0000038 ! follicular fluid +relationship: part_of UBERON:0001305 ! ovarian follicle [Term] id: UBERON:0000042 @@ -201910,7 +303806,7 @@ is_a: UBERON:0007846 {source="VSAO"} ! dense regular connective tissue relationship: connects UBERON:0001474 ! bone element relationship: connects UBERON:0001630 ! muscle organ relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg xsd:anyURI property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"} @@ -201998,7 +303894,6 @@ xref: EHDAA:5621 xref: EHDAA:918 xref: EMAPA:32846 xref: EV:0100372 -xref: FBbt:00005137 xref: FMA:5884 xref: MA:0002406 xref: MAT:0000207 @@ -202047,6 +303942,7 @@ id: UBERON:0000052 name: fornix of brain namespace: uberon def: "A C-shaped bundle of fibres (axons) in the brain, and carries signals from the hippocampus to the mammillary bodies and septal nuclei. It is typically divided into the columns (crus), body, commissure and the pre-commissural and post-commissural fornix (MM)." [BIRNLEX:705] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brain fornix" EXACT [] @@ -202067,9 +303963,9 @@ xref: EMAPA:35352 xref: FMA:61965 {notes="inferred"} xref: FMA:83865 xref: HBA:9249 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=268 {source="BIRNLEX:705"} xref: MA:0002747 xref: NCIT:C32289 +xref: neuronames:268 {source="BIRNLEX:705"} xref: SCTID:279302004 xref: UMLS:C0152334 {source="BIRNLEX:705"} xref: UMLS:C0458370 {source="ncithesaurus:Cerebral_Fornix"} @@ -202077,6 +303973,7 @@ xref: Wikipedia:fornix_of_brain is_a: UBERON:0007702 ! tract of brain relationship: part_of UBERON:0002421 {source="NIFSTD"} ! hippocampal formation property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/21/Gray747.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000053 @@ -202140,9 +304037,11 @@ name: vessel namespace: uberon def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165] subset: grouping_class +subset: human_reference_atlas subset: pheno_slim is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0006314 ! bodily fluid +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000056 @@ -202151,6 +304050,7 @@ namespace: uberon def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." [GO:0090189, Wikipedia:Ureter] def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." [GO:0090189, http://en.wikipedia.org/wiki/Ureter] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -202191,7 +304091,9 @@ relationship: channels_into UBERON:0001255 ! urinary bladder relationship: develops_from UBERON:0005081 {source="GO"} ! ureter ureteric bud relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism relationship: part_of UBERON:0036295 ! renal pelvis/ureter +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg xsd:anyURI property_value: depicted:by Urinary:system.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010254", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -202237,6 +304139,7 @@ xref: XAO:0000153 is_a: UBERON:0000062 ! organ is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: capable_of_part_of GO:0060073 ! micturition relationship: channel_for UBERON:0001088 ! urine relationship: channels_from UBERON:0001255 ! urinary bladder relationship: continuous_with UBERON:0001255 ! urinary bladder @@ -202244,6 +304147,7 @@ relationship: develops_from UBERON:0000164 {notes="pelvic part of UG sinus gives relationship: develops_from UBERON:0013241 {source="Wikipedia"} ! embryonic urethral groove relationship: part_of UBERON:0001556 ! lower urinary tract property_value: depicted:by Female:anatomy.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI property_value: UBPROP:0000007 "urethral" xsd:string property_value: UBPROP:0000008 "In human males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening." xsd:string @@ -202285,6 +304189,7 @@ namespace: uberon def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [http://en.wikipedia.org/wiki/Large_intestine_(anatomy), ISBN:0073040584] def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -202303,6 +304208,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0021851 xref: http://www.snomedbrowser.com/Codes/Details/181254001 xref: MA:0000333 xref: MESH:A03.492.411.495 +xref: MESH:D007420 xref: MIAA:0000046 xref: NCIT:C12379 xref: OpenCyc:Mx4rvVkF5pwpEbGdrcN5Y29ycA @@ -202314,8 +304220,10 @@ xref: XAO:0000131 is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element relationship: contributes_to_morphology_of UBERON:0000160 ! intestine +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0004907 ! lower digestive tract +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000054", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000054", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566"} @@ -202366,7 +304274,6 @@ xref: TGMA:0001823 xref: VHOG:0001759 xref: XAO:0003000 xref: ZFA:0000037 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000465 ! material anatomical entity relationship: existence_ends_during_or_before UBERON:0000071 ! death stage relationship: existence_starts_during_or_after UBERON:0000106 ! zygote stage @@ -202398,8 +304305,8 @@ xref: SCTID:272625005 xref: UMLS:C0178784 {source="ncithesaurus:Organ"} xref: WBbt:0003760 xref: Wikipedia:Organ_(anatomy) -is_a: BFO:0000040 ! material entity is_a: UBERON:0010000 ! multicellular anatomical structure +disjoint_from: UBERON:0002095 {source="PMID:28192867"} ! mesentery disjoint_from: UBERON:0034921 ! multi organ part structure relationship: capable_of GO:0008150 ! biological_process relationship: existence_starts_during_or_after UBERON:0000111 ! organogenesis stage @@ -202451,6 +304358,7 @@ id: UBERON:0000065 name: respiratory tract namespace: uberon def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas xref: EHDAA2:0001606 xref: EHDAA:1568 xref: EHDAA:2219 @@ -202463,6 +304371,7 @@ is_a: UBERON:0001005 ! respiratory airway is_a: UBERON:0004119 ! endoderm-derived structure relationship: develops_from UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut relationship: develops_from UBERON:0008947 ! respiratory primordium +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000066 @@ -202563,6 +304472,7 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0001016 ! nervous system +relationship: dc-contributor https://orcid.org/0000-0001-9114-8737 relationship: part_of UBERON:0001016 ! nervous system created_by: Melissa Haendel creation_date: 2009-06-18T09:00:04Z @@ -202600,12 +304510,13 @@ xref: Wikipedia:Glomerulus xref: ZFA:0001288 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: dc-contributor https://orcid.org/0000-0001-9114-8737 relationship: develops_from UBERON:0005749 ! glomerular tuft relationship: part_of UBERON:0001229 {source="FMA", source="MA"} ! renal corpuscle +relationship: surrounded_by UBERON:0001230 ! glomerular capsule property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg xsd:anyURI -property_value: depicted:by Renal:corpuscle.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg xsd:anyURI property_value: UBPROP:0000012 "ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule?" xsd:string {external_ontology="ZFA"} -created_by: Melissa Haendel creation_date: 2009-06-18T09:26:37Z [Term] @@ -202624,7 +304535,6 @@ xref: http://www.snomedbrowser.com/Codes/Details/118966000 xref: NCIT:C34076 xref: SCTID:118966000 xref: UMLS:C1519343 {source="ncithesaurus:Skeletal_System_Part"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: composed_primarily_of UBERON:0004765 ! skeletal element relationship: only_in_taxon NCBITaxon:7711 ! Chordata @@ -202729,6 +304639,9 @@ xref: VHOG:0000725 xref: Wikipedia:Male_reproductive_system_(human) xref: XAO:0000155 is_a: UBERON:0000990 ! reproductive system +intersection_of: UBERON:0000990 ! reproductive system +intersection_of: part_of UBERON:0003101 ! male organism +disjoint_from: UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0003101 ! male organism property_value: UBPROP:0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000725", ontology="VHOG", source="ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", source="http://bgee.unil.ch/"} @@ -202887,6 +304800,7 @@ xref: UMLS:C1284058 {source="ncithesaurus:Metanephric_Diverticulum"} xref: Ureteric:bud xref: VHOG:0000541 xref: Wikipedia:Ureteric_bud +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000083 ! mesonephric tubule is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac is_a: UBERON:0034969 ! epithelial layer of duct @@ -202910,14 +304824,18 @@ xref: BTO:0001508 xref: EHDAA2:0000005 xref: FMA:292334 xref: GAID:1295 -xref: MESH:A16.254.270.550 +xref: MESH:D009028 xref: NCIT:C34212 xref: SCTID:361474003 xref: UMLS:C0026573 {source="ncithesaurus:Morula"} xref: Wikipedia:Morula is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000922 ! embryo +relationship: existence_ends_during UBERON:0000107 ! cleavage stage +relationship: existence_starts_during UBERON:0000107 ! cleavage stage +relationship: has_part CL:0000353 ! blastoderm cell relationship: part_of UBERON:0004716 {source="EHDAA2"} ! conceptus +relationship: surrounded_by UBERON:0000086 ! zona pellucida property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png xsd:anyURI property_value: UBPROP:0000012 "EHDAA2 has embryo starting later" xsd:string {external_ontology="EHDAA2"} @@ -202926,6 +304844,7 @@ id: UBERON:0000086 name: zona pellucida namespace: uberon def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "oolemma" RELATED [BTO:0003135] @@ -202953,8 +304872,11 @@ xref: Wikipedia:Zona_pellucida xref: ZFA:0001111 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000476 ! acellular anatomical structure +relationship: bounding_layer_of CL:0000023 ! oocyte +relationship: has_part CHEBI:17089 ! glycoprotein relationship: part_of UBERON:0000992 ! ovary property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000720", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159", source="http://bgee.unil.ch/"} [Term] @@ -202983,7 +304905,8 @@ xref: Wikipedia:Inner_cell_mass is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000358 {source="Wikipedia"} ! blastocyst -property_value: depicted:by Blastocyst:English.svg xsd:anyURI +relationship: surrounded_by UBERON:0000088 {source="Wikipedia"} ! trophoblast +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI property_value: UBPROP:0000001 "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass]" xsd:string @@ -202995,6 +304918,7 @@ namespace: uberon def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031] comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] subset: early_development +subset: human_reference_atlas subset: pheno_slim synonym: "massa cellularis externa" RELATED LATIN [Wikipedia:Trophoblast] synonym: "trophoblast layer" EXACT [MP:0005031] @@ -203005,16 +304929,18 @@ xref: CALOHA:TS-1070 xref: EV:0100120 xref: FMA:83029 xref: GAID:1152 -xref: MESH:A11.936 +xref: MESH:D014327 xref: NCIT:C93292 xref: SCTID:362839005 xref: UMLS:C0041178 {source="ncithesaurus:Trophoblast"} xref: Wikipedia:Trophoblast is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure +relationship: composed_primarily_of CL:0000351 ! trophoblast cell relationship: develops_from UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! trophectoderm relationship: part_of UBERON:0000358 ! blastocyst -property_value: depicted:by Blastocyst:English.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" xsd:string {date_retrieved="2012-08-23", external_class="MP:0005031", external_class_label="trophoblast layer", ontology="MP", source="ISBN:0-683-40008-8"} property_value: UBPROP:0000007 "trophoblastic" xsd:string property_value: UBPROP:0000011 "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" xsd:string {source="PMID:19829370"} @@ -203146,7 +305072,7 @@ subset: grouping_class subset: non_informative xref: Wikipedia:Sulcus_(anatomy) is_a: UBERON:0000464 ! anatomical space -created_by: cjm +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 creation_date: 2009-04-09T06:23:22Z [Term] @@ -203160,6 +305086,7 @@ synonym: "membrane of organ" EXACT [] xref: FMA:7145 is_a: UBERON:0000062 ! organ relationship: composed_primarily_of UBERON:0011823 {source="FMA-def"} ! dense connective tissue +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 created_by: cjm creation_date: 2009-07-30T05:19:13Z @@ -203177,11 +305104,11 @@ xref: XAO:0004190 xref: ZFA:0001648 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 relationship: overlaps UBERON:0005428 {source="Wikipedia"} ! vagal neural crest relationship: part_of UBERON:0002342 ! neural crest property_value: UBPROP:0000001 "A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]." xsd:string {source="DOI:10.1242/dev.091751"} property_value: UBPROP:0000012 "ZFA treats this as a subtype of NC." xsd:string {external_ontology="ZFA"} -created_by: cjm creation_date: 2009-07-30T07:57:38Z [Term] @@ -203189,6 +305116,7 @@ id: UBERON:0000101 name: lobe of lung namespace: uberon def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO] +subset: human_reference_atlas subset: pheno_slim synonym: "lung lobe" EXACT [] synonym: "pulminory lobe" EXACT [] @@ -203203,7 +305131,9 @@ xref: SCTID:245524004 xref: UMLS:C0225752 {source="ncithesaurus:Lung_Lobe"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe +relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000102 @@ -203259,6 +305189,7 @@ xref: EFO:0000399 xref: FBdv:00007012 xref: FMA:24120 xref: HsapDv:0000000 +xref: MESH:D008018 xref: MmusDv:0000000 xref: ncithesaurus:Developmental_Stage xref: OlatDv:0000010 @@ -203321,6 +305252,7 @@ xref: Cleavage:(embryo) xref: EFO:0001290 xref: FBdv:00000054 xref: MESH:A16.254.270 +xref: MESH:D002970 xref: MmusDv:0000004 xref: OGES:000015 xref: OGES:000020 @@ -203435,11 +305367,58 @@ relationship: preceded_by UBERON:0000110 ! neurula stage relationship: simultaneous_with GO:0048513 ! animal organ development property_value: seeAlso https://github.com/obophenotype/uberon/issues/533 xsd:anyURI +[Term] +id: UBERON:0000112 +name: sexually immature stage +namespace: uberon +subset: efo_slim +synonym: "immature stage" EXACT [VHOG:FB] +synonym: "juvenile stage" NARROW [XAO:1000010] +synonym: "subadult stage" RELATED [http://eol.org/schema/terms/subadult] +xref: BILS:0000112 +xref: BTO:0002168 +xref: EFO:0001300 +xref: EV:0300051 +xref: MmusDv:0000043 +xref: OGES:000009 +xref: XAO:1000010 +xref: XtroDO:0000083 +xref: ZFS:0000051 +is_a: BFO:0000003 ! occurrent +is_a: UBERON:0000105 ! life cycle stage +relationship: part_of UBERON:0000066 ! fully formed stage +property_value: seeAlso https://github.com/obophenotype/uberon/issues/427 xsd:anyURI +property_value: UBPROP:0000001 "The stage of being a sexually immature adult animal[XAO:1000010]." xsd:string {source="XAO:1000010"} +property_value: UBPROP:0000008 "In mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother)" xsd:string + +[Term] +id: UBERON:0000113 +name: post-juvenile adult stage +namespace: uberon +def: "The stage of being a sexually mature adult animal." [https://orcid.org/0000-0002-6601-2165] +synonym: "adult stage" BROAD [] +xref: BILS:0000113 +xref: EV:0300064 +xref: EV:0300070 +xref: MIAA:0000403 +xref: MmusDv:0000110 +xref: OGES:000026 +xref: OGES:000027 +xref: XAO:1000093 +xref: ZFS:0000044 +is_a: BFO:0000003 ! occurrent +is_a: UBERON:0000105 ! life cycle stage +relationship: part_of UBERON:0000066 ! fully formed stage +relationship: preceded_by UBERON:0000112 ! sexually immature stage +property_value: seeAlso https://github.com/obophenotype/uberon/issues/345 xsd:anyURI +property_value: seeAlso https://github.com/obophenotype/uberon/issues/499 xsd:anyURI + [Term] id: UBERON:0000114 name: lung connective tissue namespace: uberon def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660] +subset: human_reference_atlas subset: pheno_slim synonym: "connective tissue of lung" EXACT [OBOL:automatic] synonym: "lung interstitial tissue" RELATED [MA:0001782] @@ -203459,6 +305438,7 @@ intersection_of: part_of UBERON:0002048 ! lung relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung relationship: transformation_of UBERON:0004883 ! lung mesenchyme +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" xsd:string [Term] @@ -203561,6 +305541,7 @@ def: "Cell layer consisting of lining cells that separates the central nervous s synonym: "BBB" RELATED [] synonym: "blood-brain barrier" EXACT [] xref: http://uri.neuinfo.org/nif/nifstd/nlx_subcell_100205 +xref: MESH:D001812 xref: NCIT:C13194 xref: UMLS:C0005854 {source="ncithesaurus:Blood-Brain_Barrier"} xref: Wikipedia:Blood-brain_barrier @@ -203568,6 +305549,16 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000119 ! cell layer relationship: part_of UBERON:0001016 ! nervous system +[Term] +id: UBERON:0000121 +name: perineurium +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0011822 ! dense irregular connective tissue +relationship: bounding_layer_of UBERON:0001019 ! nerve fasciculus +relationship: has_part GO:0005581 ! collagen trimer +relationship: located_in UBERON:0000124 ! epineurium +relationship: part_of UBERON:0001016 ! nervous system + [Term] id: UBERON:0000122 name: neuron projection bundle @@ -203602,6 +305593,14 @@ is_a: UBERON:0006804 {source="FMA"} ! reticular tissue relationship: part_of UBERON:0000010 ! peripheral nervous system property_value: UBPROP:0000001 "a layer of delicate connective tissue that encloses the myelin sheath of a nerve fiber within a funiculus[Wikipedia:Endodeurium]." xsd:string {source="Wikipedia:Endodeurium"} +[Term] +id: UBERON:0000124 +name: epineurium +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0011822 ! dense irregular connective tissue +relationship: part_of UBERON:0000010 ! peripheral nervous system +relationship: surrounds UBERON:0001021 ! nerve + [Term] id: UBERON:0000125 name: neural nucleus @@ -203664,6 +305663,7 @@ xref: EMAPA:35338 xref: EV:0100267 xref: FMA:54572 xref: MA:0001014 +xref: MESH:D065828 xref: NCIT:C12898 xref: SCTID:280166009 xref: UMLS:C0228740 {source="ncithesaurus:Facial_Nerve_Nucleus"} @@ -203671,6 +305671,10 @@ xref: VHOG:0001412 is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus +intersection_of: UBERON:0000126 ! cranial nerve nucleus +intersection_of: extends_fibers_into UBERON:0001647 ! facial nerve +relationship: contributes_to_morphology_of UBERON:0000988 ! pons +relationship: extends_fibers_into UBERON:0001647 ! facial nerve relationship: immediate_transformation_of UBERON:0010123 {evidence="definitional"} ! future facial nucleus relationship: part_of UBERON:0000988 ! pons property_value: UBPROP:0000012 "FMA has 3 subclasses - left, right and motor nucleus of facial nerve, but no defs. It's not clear how facial nucleus is distinct from facial motor nucleus." xsd:string {external_ontology="FMA"} @@ -203716,6 +305720,7 @@ name: theca cell layer namespace: uberon def: "A layer of the ovarian follicle that consists of theca cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "layer of theca cells" EXACT [] @@ -203740,6 +305745,7 @@ is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0001305 ! ovarian follicle +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "The theca folliculi are responsible for the production of testosterone from androstenedione in females, and indirectly the production of estrogens by supplying the neighboring granulosa cells with androstenedione that can then be used as a substrate for aromatase. [Wikipedia:Theca_of_follicle]" xsd:string [Term] @@ -203748,6 +305754,7 @@ name: theca externa namespace: uberon alt_id: UBERON:0005182 def: "The theca externa is the outer layers of the theca folliculi. It contains abundant collagen and is mainly supportive." [Wikipedia:Theca_externa] +subset: human_reference_atlas subset: pheno_slim synonym: "external coat of theca folliculi" RELATED [BTO:0002852] synonym: "ovary theca externa" EXACT [MA:0001713] @@ -203764,6 +305771,7 @@ is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/50/Mature_Graffian_follicle.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000157 @@ -203771,6 +305779,7 @@ name: theca interna namespace: uberon alt_id: UBERON:0005183 def: "Theca interna cells express receptors for luteinizing hormone, which when activated will stimulate the production of androstenedione from cholesterol by the enzyme desmolase. Androstenedione ultimately gives the granulosa cells the precursor substrate for estrogen manufacturing." [Wikipedia:Theca_externa#Theca_interna] +subset: human_reference_atlas subset: pheno_slim synonym: "internal coat of capsule of Graafian follicle" RELATED [BTO:0002851] synonym: "ovary theca interna" EXACT [MA:0001714] @@ -203786,6 +305795,7 @@ is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure relationship: part_of UBERON:0000155 ! theca cell layer +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000158 @@ -203797,7 +305807,6 @@ xref: FMA:30322 xref: FMA:82500 xref: MESH:D008566 xref: NCIT:C12749 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004923 ! organ component layer relationship: bounding_layer_of UBERON:0000064 ! organ part property_value: UBPROP:0000001 "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures." xsd:string {source="ncithesaurus:Membrane"} @@ -203808,6 +305817,7 @@ name: anal canal namespace: uberon def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [http://en.wikipedia.org/wiki/Anal_canal] def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "anal canal" EXACT [] @@ -203831,6 +305841,7 @@ xref: galen:AnalCanal xref: http://linkedlifedata.com/resource/umls/id/C0227411 xref: http://www.snomedbrowser.com/Codes/Details/245438008 xref: MA:0000330 +xref: MESH:D001003 xref: NCIT:C12375 xref: SCTID:245438008 xref: UMLS:C0227411 {source="ncithesaurus:Anal_Canal"} @@ -203845,6 +305856,7 @@ relationship: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001353 ! anal region property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png xsd:anyURI property_value: editor_note "requires alignment with EHDAA2 and complete developmental relationships" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000160 @@ -203875,6 +305887,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/256876008 xref: MA:0000328 xref: MA:0001524 xref: MESH:A03.492.411 +xref: MESH:D007422 xref: MIAA:0000043 xref: NCIT:C12736 xref: SCTID:256876008 @@ -203935,6 +305948,7 @@ xref: XAO:0000244 xref: ZFA:0005781 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0013522 ! subdivision of tube +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001555 {source="ZFA"} ! digestive tract relationship: part_of UBERON:0004122 {source="AAO"} ! genitourinary system property_value: editor_note "adding df link to embryonic cloaca leads to a cycle in uberon-simple, as cloaca is a suberclass of embryonic cloaca" xsd:string @@ -203996,6 +306010,7 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: contributes_to_morphology_of UBERON:0000163 ! embryonic cloaca relationship: develops_from UBERON:0003064 ! intermediate mesoderm +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000163 {source="MP-def"} ! embryonic cloaca property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png xsd:anyURI property_value: UBPROP:0000001 "The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000414", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/urogenital+sinus"} @@ -204096,8 +306111,8 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000161 {source="FMA"} ! orifice relationship: overlaps UBERON:0001004 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! respiratory system relationship: part_of UBERON:0000165 ! mouth -property_value: UBPROP:0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000280", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)"} property_value: UBPROP:0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000280", ontology="VHOG", source="DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)", source="http://bgee.unil.ch/"} +property_value: UBPROP:0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000280", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)"} [Term] id: UBERON:0000167 @@ -204167,6 +306182,7 @@ id: UBERON:0000170 name: pair of lungs namespace: uberon def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim synonym: "lungs" EXACT [] synonym: "lungs pair" EXACT [] @@ -204174,7 +306190,6 @@ synonym: "pulmones" EXACT LATIN [FMA:68877, FMA:TA] synonym: "set of lungs" EXACT [] xref: FMA:68877 xref: OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection @@ -204186,6 +306201,7 @@ relationship: has_member UBERON:0002168 ! left lung relationship: has_member UBERON:0002168 {cardinality="1"} ! left lung relationship: located_in UBERON:0002224 ! thoracic cavity relationship: part_of UBERON:0001558 {source="FMA-abduced"} ! lower respiratory tract +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000171 @@ -204232,6 +306248,10 @@ xref: NCIT:C13188 xref: UMLS:C0002638 {source="ncithesaurus:Amniotic_Fluid"} xref: VHOG:0001267 is_a: UBERON:0000463 ! organism substance +relationship: functionally_related_to GO:0001701 ! in utero embryonic development +relationship: located_in UBERON:0000305 ! amnion +relationship: only_in_taxon NCBITaxon:32524 ! Amniota +relationship: surrounds UBERON:0000922 ! embryo [Term] id: UBERON:0000174 @@ -204252,6 +306272,9 @@ xref: ENVO:02000022 xref: FMA:9674 xref: galen:Excretion is_a: UBERON:0000463 ! organism substance +intersection_of: UBERON:0000463 ! organism substance +intersection_of: output_of GO:0007588 ! excretion +relationship: output_of GO:0007588 ! excretion [Term] id: UBERON:0000178 @@ -204260,6 +306283,7 @@ namespace: uberon def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://en.wikipedia.org/wiki/Blood, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9] def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -204291,7 +306315,6 @@ xref: VHOG:0000224 xref: Wikipedia:Blood xref: XAO:0000124 xref: ZFA:0000007 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000179 ! haemolymphatic fluid relationship: dc-contributor https://github.com/cmungall @@ -204304,6 +306327,7 @@ relationship: located_in UBERON:0002049 {source="https://github.com/obophenotype relationship: located_in UBERON:0002049 {source="https://github.com/obophenotype/uberon/issues/1330"} ! vasculature relationship: part_of UBERON:0002390 ! hematopoietic system property_value: IAO:0000232 "This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000007", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO"} @@ -204321,6 +306345,7 @@ xref: CARO:0000081 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: part_of UBERON:0002193 ! hemolymphoid system +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0002193 ! hemolymphoid system created_by: cjm @@ -204340,6 +306365,8 @@ xref: SCTID:181942005 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005055 ! zone of long bone is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0001423 ! radius bone relationship: part_of UBERON:0004413 {source="FMA"} ! proximal epiphysis of radius [Term] @@ -204360,8 +306387,8 @@ synonym: "gyrus of neuraxis" EXACT [FMA:83874] synonym: "neuraxis gyrus" EXACT [FMA:83874] xref: BTO:0002495 xref: FMA:83874 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1211 xref: NCIT:C32290 +xref: neuronames:1211 xref: SCTID:279165009 xref: UMLS:C0458308 {source="ncithesaurus:Cerebral_Gyrus"} xref: Wikipedia:Gyrus @@ -204388,7 +306415,7 @@ synonym: "dorsal telencephalon" EXACT [ZFA:0000505] xref: BTO:0003399 xref: DMBA:15903 xref: EFO:0003534 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3240 +xref: neuronames:3240 xref: SCTID:369224000 xref: TAO:0000505 xref: TAO:0007007 @@ -204397,12 +306424,12 @@ xref: Wikipedia:Pallium_(neuroanatomy) xref: ZFA:0000505 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 relationship: part_of UBERON:0001893 ! telencephalon property_value: RO:0002175 NCBITaxon:7762 {source="PMID:8932866"} property_value: seeAlso https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/87 xsd:anyURI property_value: UBPROP:0000003 "In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume." xsd:string {source="Wikipedia:Avian_pallium", taxon="NCBITaxon:8782"} property_value: UBPROP:0000008 "In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus" xsd:string {source="WP"} -created_by: cjm creation_date: 2009-04-18T12:03:09Z [Term] @@ -204423,9 +306450,9 @@ xref: TAO:0000304 xref: ZFA:0000304 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: dc-contributor https://orcid.org/0000-0002-6601-2165 relationship: part_of UBERON:0001893 ! telencephalon property_value: UBPROP:0000012 "BTO term refers specifically to the avian structure" xsd:string {external_ontology="BTO"} -created_by: cjm creation_date: 2009-04-18T12:12:27Z [Term] @@ -204456,8 +306483,8 @@ is_a: UBERON:0008907 ! dermal bone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: part_of UBERON:0003113 {source="cjm"} ! dermatocranium -property_value: depicted:by Frontal:bone.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png xsd:anyURI property_value: UBPROP:0000008 "fused in humans, paired in other animals" xsd:string property_value: UBPROP:0000011 "In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993)." xsd:string @@ -204521,7 +306548,9 @@ xref: Wikipedia:Ligament xref: XAO:0004031 xref: ZFA:0001675 is_a: UBERON:0000062 ! organ -property_value: depicted:by Knee:diagram.svg xsd:anyURI +relationship: has_part UBERON:0002384 ! connective tissue +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg xsd:anyURI property_value: UBPROP:0000001 "Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496]." xsd:string {source="FMA:21496"} property_value: UBPROP:0000001 "Portion of connective tissue that connects bone or cartilage.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001682", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000003 "Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001272", ontology="VHOG", source="PMID:8710894 Ohno S, The notion of the Cambrian pananimalia genome. PNAS (1996)", source="http://bgee.unil.ch/"} @@ -204546,8 +306575,10 @@ xref: VHOG:0000855 xref: Wikipedia:Amniotic_cavity is_a: UBERON:0012466 ! extraembryonic cavity is_a: UBERON:0012467 ! enclosed anatomical space +relationship: contains UBERON:0000173 ! amniotic fluid relationship: develops_from UBERON:0000087 {source="EHDAA2"} ! inner cell mass relationship: develops_from UBERON:0009742 {source="cjm"} ! proamniotic cavity +relationship: surrounded_by UBERON:0005971 ! amniotic fold property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png xsd:anyURI property_value: UBPROP:0000001 "The closed sac between the embryo and the amnion, containing the amniotic fluid. [Free_Online_Medical_Dictionary]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000855", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/amniotic+cavity"} @@ -204565,7 +306596,6 @@ xref: NCIT:C96299 xref: SCTID:361885006 xref: UMLS:C0224856 {source="ncithesaurus:Tendon_Sheath"} xref: Wikipedia:Tendon_sheath -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -204580,6 +306610,7 @@ id: UBERON:0000305 name: amnion namespace: uberon def: "The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected." [MGI:csmith, MP:0005029] +subset: human_reference_atlas subset: pheno_slim synonym: "amnios" EXACT [http://placentation.ucsd.edu/glossfs.html] xref: BTO:0000065 @@ -204590,7 +306621,7 @@ xref: EMAPA:16109 xref: EV:0100122 xref: FMA:80223 xref: GAID:1298 -xref: MESH:A16.254.403.277 +xref: MESH:D000650 xref: NCIT:C12365 xref: SCTID:181457005 xref: UMLS:C0002630 {source="ncithesaurus:Amnion"} @@ -204599,7 +306630,14 @@ xref: Wikipedia:Amnion is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0005971 {source="ISBN:0073040584"} ! amniotic fold +relationship: has_developmental_contribution_from UBERON:0000924 ! ectoderm +relationship: has_developmental_contribution_from UBERON:0004871 ! somatic layer of lateral plate mesoderm +relationship: has_part UBERON:0003254 ! amniotic ectoderm +relationship: has_part UBERON:0003262 ! amniotic mesoderm +relationship: only_in_taxon NCBITaxon:32524 ! Amniota +relationship: surrounds UBERON:0000922 ! embryo property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000721", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000721", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "amniotic" xsd:string @@ -204620,6 +306658,7 @@ xref: BTO:0000128 xref: GAID:1294 xref: http://en.wikipedia.org/wiki/Blastula xref: MESH:A16.254.270.274 +xref: MESH:D036703 xref: OGEM:000006 xref: OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg xref: Wikipedia:Blastula @@ -204691,11 +306730,21 @@ is_a: UBERON:0014892 ! skeletal muscle organ relationship: develops_from UBERON:0010962 ! extensor pre-muscle mass relationship: part_of UBERON:0000026 ! appendage +[Term] +id: UBERON:0000313 +name: portion of cartilage tissue in tibia +is_a: UBERON:0004270 ! lower leg connective tissue +is_a: UBERON:0007391 ! pelvic appendage cartilage tissue +intersection_of: UBERON:0002418 ! cartilage tissue +intersection_of: part_of UBERON:0000979 ! tibia +relationship: part_of UBERON:0000979 ! tibia + [Term] id: UBERON:0000314 name: cecum mucosa namespace: uberon def: "A mucosa that is part of a cecum [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "caecum mucosa" EXACT [OBOL:automatic] synonym: "caecum mucosa of organ" EXACT [OBOL:automatic] synonym: "caecum mucous membrane" EXACT [OBOL:automatic] @@ -204723,7 +306772,10 @@ synonym: "organ mucosa of intestinum crassum caecum" EXACT [OBOL:automatic] xref: BTO:0000213 xref: FMA:14998 is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001153 ! caecum relationship: part_of UBERON:0001153 ! caecum +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000315 @@ -204737,6 +306789,9 @@ synonym: "spatium leptomeningeum" RELATED LATIN [BTO:0000230] synonym: "spatium subarachnoideum" RELATED LATIN [BTO:0000230] synonym: "spatium subarachnoideum" RELATED LATIN [Wikipedia:Subarachnoid_space] synonym: "subarachnoid cavity" RELATED [BTO:0000230] +synonym: "subarachnoid space of central nervous system" EXACT [] +synonym: "subarachnoid space of CNS" EXACT [] +synonym: "subarachnoid space of neuraxis" EXACT [FMA:322060] xref: BTO:0000230 xref: EMAPA:32666 xref: FMA:83716 @@ -204746,10 +306801,26 @@ xref: SCTID:362311001 xref: Wikipedia:Subarachnoid_space is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: adjacent_to UBERON:0002361 ! pia mater +intersection_of: adjacent_to UBERON:0002362 ! arachnoid mater +relationship: adjacent_to UBERON:0002361 ! pia mater +relationship: adjacent_to UBERON:0002362 ! arachnoid mater +relationship: contains UBERON:0001359 ! cerebrospinal fluid +relationship: contains UBERON:0001981 ! blood vessel relationship: part_of UBERON:0000955 ! brain +relationship: part_of UBERON:0010743 ! meningeal cluster property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray769-en.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray769.png xsd:anyURI +[Term] +id: UBERON:0000316 +name: cervical mucus +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: produced_by UBERON:0000002 ! uterine cervix +relationship: produced_by UBERON:0000002 ! uterine cervix + [Term] id: UBERON:0000317 name: colonic mucosa @@ -204758,6 +306829,7 @@ alt_id: UBERON:0003347 alt_id: UBERON:0004981 def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas synonym: "colon mucosa" EXACT [FMA:14984] synonym: "colon mucous membrane" EXACT [OBOL:automatic] synonym: "colonic mucosa" EXACT [] @@ -204778,6 +306850,7 @@ is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000320 @@ -204785,6 +306858,7 @@ name: duodenal mucosa namespace: uberon alt_id: UBERON:0003348 def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "doudenal mucosa" EXACT [FMA:14942] synonym: "duodenal mucous membrane" EXACT [FMA:14942] synonym: "duodenum mucosa" RELATED [BTO:0000367] @@ -204797,13 +306871,16 @@ xref: FMA:14942 xref: MA:0003207 xref: SCTID:362146003 is_a: UBERON:0001204 ! mucosa of small intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0002114 ! duodenum +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000323 name: late embryo namespace: uberon -def: "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." [BGEE:ANiknejad] +def: "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." [https://orcid.org/0000-0003-3308-6245] subset: efo_slim subset: pheno_slim synonym: "embryo late growth stage" RELATED [BTO:0000449] @@ -204821,6 +306898,9 @@ xref: OpenCyc:Mx4rvZfC2ZwpEbGdrcN5Y29ycA xref: SCTID:83418008 xref: UMLS:C0015965 {source="ncithesaurus:Fetus"} is_a: UBERON:0000922 ! embryo +intersection_of: UBERON:0000922 ! embryo +intersection_of: existence_starts_and_ends_during UBERON:0007220 ! late embryonic stage +relationship: existence_starts_and_ends_during UBERON:0007220 ! late embryonic stage property_value: editor_note "TODO - check fetus/embryo. WP: An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus." xsd:string property_value: UBPROP:0000001 "Fetal structure, which is a developmental form of a vertebrate animal at any given time point from 8 weeks of gestation to birth (or hatching). Examples: There is only one fetus[FMA:63919]." xsd:string {source="FMA:63919"} @@ -204838,6 +306918,24 @@ is_a: UBERON:0002365 {source="cjm"} ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: part_of UBERON:0006924 {source="ISBN:0073040584"} ! stomach glandular epithelium +[Term] +id: UBERON:0000326 +name: pancreatic juice +namespace: uberon +def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157] +synonym: "pancreatic fluid" RELATED [] +synonym: "pancreatic secretion" RELATED [] +synonym: "succus pancreaticus" RELATED [BTO:0000504] +xref: BTO:0000504 +xref: CALOHA:TS-2235 +xref: FMA:62973 +xref: GAID:1166 +xref: MESH:D010189 +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0001264 ! pancreas +relationship: produced_by UBERON:0001264 ! pancreas + [Term] id: UBERON:0000328 name: gut wall @@ -204861,6 +306959,7 @@ id: UBERON:0000331 name: ileal mucosa namespace: uberon def: "A mucosa that is part of a ileum [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "ileal mucous membrane" EXACT [FMA:14956] synonym: "ileum mucosa" EXACT [FMA:14956] synonym: "ileum mucosa" EXACT [OBOL:automatic] @@ -204878,7 +306977,10 @@ xref: FMA:14956 xref: MA:0003216 xref: SCTID:85458007 is_a: UBERON:0001204 ! mucosa of small intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000332 @@ -204892,7 +306994,6 @@ xref: BTO:0000635 xref: FMA:74596 xref: SCTID:328639002 xref: SCTID:5023006 -is_a: BFO:0000040 ! material entity is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: composed_primarily_of CL:0000136 ! fat cell @@ -204967,7 +307068,7 @@ xref: UMLS:C0230069 {source="ncithesaurus:Throat"} xref: Wikipedia:Throat is_a: UBERON:0034929 ! external soft tissue zone relationship: part_of UBERON:0000974 ! neck -property_value: depicted:by Throat:Diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/1/16/Throat_Diagram.png xsd:anyURI property_value: UBPROP:0000007 "gular" xsd:string property_value: UBPROP:0000008 "The hyoid bone and the clavicle are the only bones located in the throat of mammals." xsd:string @@ -205039,6 +307140,7 @@ name: ophthalmic nerve namespace: uberon def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead." [MP:0009798, Wikipedia:Ophthalmic_nerve] comment: Terminology notes. This nerve is known by a ridiculous number of names[http://palaeos.com/vertebrates/glossary/glossaryPo.html] +subset: human_reference_atlas subset: pheno_slim synonym: "ciliary nerve" RELATED [http://palaeos.com/vertebrates/glossary/glossaryPo.html] synonym: "cranial nerve V, branch V1" EXACT [http://orcid.org/0000-0002-6601-2165] @@ -205082,8 +307184,12 @@ xref: SCTID:280210000 xref: UMLS:C0029082 {source="ncithesaurus:Ophthalmic_Nerve"} xref: VHOG:0001349 xref: Wikipedia:Ophthalmic_nerve +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011779 ! nerve of head region +relationship: branching_part_of UBERON:0001645 ! trigeminal nerve relationship: develops_from UBERON:0035597 ! profundal placode +relationship: innervates UBERON:1000021 ! skin of face +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Sensory medial ramus of the trigeminal nerve.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010648", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The profundus nerve is a distinct nerve only in fishes. (...) In mammals, the profundus nerve is the same as the most rostral (ophthalmic) branch of the trigeminal nerve.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001349", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.177", source="http://bgee.unil.ch/"} @@ -205100,9 +307206,9 @@ xref: BTO:0000928 xref: CALOHA:TS-1307 xref: FMA:242000 xref: GAID:615 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2055 -xref: MESH:A08.186.211.577 +xref: MESH:D008032 xref: NCIT:C94541 +xref: neuronames:2055 xref: OpenCyc:Mx4rwAeba5wpEbGdrcN5Y29ycA xref: SCTID:361342009 xref: UMLS:C0023715 {source="ncithesaurus:Limbic_System"} @@ -205110,9 +307216,19 @@ xref: Wikipedia:Limbic_system is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001890 ! forebrain -property_value: depicted:by Brain:limbicsystem.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg xsd:anyURI property_value: editor_note "obsoletion proposes. The current part_of children were chosen as the intersection of what is stated in wikipedia and in the FMA. NIF: We are including Limbic System because it is still used by neuroscientists and others, but as a data annotation term, it is very poor because it is not a clearly defined entity." xsd:string +[Term] +id: UBERON:0000351 +name: nuchal ligament +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0008846 ! skeletal ligament +relationship: attaches_to UBERON:0001676 ! occipital bone +relationship: attaches_to UBERON:0002413 ! cervical vertebra +relationship: part_of UBERON:0012477 ! dorsal part of neck + [Term] id: UBERON:0000353 name: parenchyma @@ -205134,7 +307250,6 @@ xref: FMA:45732 xref: NCIT:C74601 xref: UMLS:C0933845 {source="ncithesaurus:Parenchyma"} xref: Wikipedia:Parenchyma -is_a: BFO:0000040 ! material entity is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: capable_of GO:0032501 ! multicellular organismal process @@ -205188,7 +307303,7 @@ xref: EMAPA:36035 xref: EV:0100394 xref: FMA:83041 xref: GAID:1153 -xref: MESH:A16.254.085 +xref: MESH:D001755 xref: NCIT:C13739 xref: SCTID:308837009 xref: UMLS:C1281743 {source="ncithesaurus:Blastocyst"} @@ -205196,8 +307311,12 @@ xref: Wikipedia:Blastocyst is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0000085 ! morula +relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage +relationship: has_part UBERON:0000087 ! inner cell mass +relationship: has_part UBERON:0000088 ! trophoblast +relationship: only_in_taxon NCBITaxon:32525 ! Theria relationship: part_of UBERON:0000307 ! blastula -property_value: depicted:by Blastocyst:English.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg xsd:anyURI property_value: editor_note "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" xsd:string [Term] @@ -205238,7 +307357,6 @@ xref: BTO:0001160 xref: FMA:74595 xref: SCTID:328538003 xref: SCTID:75330005 -is_a: BFO:0000040 ! material entity is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: composed_primarily_of CL:0000988 ! hematopoietic cell @@ -205250,6 +307368,8 @@ id: UBERON:0000362 name: renal medulla namespace: uberon def: "The inner portion of the kidney consisting of the renal pyramids." [ISBN:0-683-40008-8, MGI:smb, MP:0003014] +comment: Note that 'renal medulla' is not synonymous with 'medullary region of kidney'. The former is composed of kidney pyramids only, while the latter covers kidney pyramids and renal columns, which are histologically different. +subset: human_reference_atlas subset: pheno_slim synonym: "kidney medulla" EXACT [OBOL:automatic] synonym: "medulla of kidney" EXACT [OBOL:automatic] @@ -205274,8 +307394,14 @@ xref: UMLS:C0022664 {source="ncithesaurus:Renal_Medulla"} xref: Wikipedia:Renal_medulla is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000958 ! medulla of organ +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0002113 ! kidney +relationship: capable_of_part_of GO:0070295 ! renal water absorption +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney +relationship: has_part UBERON:0004200 ! kidney pyramid relationship: part_of UBERON:0002113 ! kidney -property_value: depicted:by Illu:kidney.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the arcuate arterioles. The arcuate arterioles each in turn branch into interlobular arterioles, which finally reach the glomeruli. At the glomerulus the blood reaches a highly disfavourable pressure gradient and a large exchange surface area, which forces the serum portion of the blood out of the vessel into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, and finally leaves the kidney by means of the collecting duct, leading to the renal ureter. The renal medulla contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. The renal medulla is hypertonic to the filtrate in the nephron and aids in the reabsorption of water" xsd:string [Term] @@ -205306,7 +307432,7 @@ xref: Wikipedia:Urothelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium relationship: part_of UBERON:0001008 ! renal system -property_value: depicted:by Harnblase:Urothel.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/91/Harnblase_Urothel.png xsd:anyURI property_value: UBPROP:0000007 "urothelial" xsd:string [Term] @@ -205346,9 +307472,9 @@ xref: EMAPA:17549 xref: EV:0100184 xref: FMA:77616 xref: GAID:667 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2339 -xref: MESH:A08.186.211.730.885.105.487 +xref: MESH:D003342 xref: NCIT:C12448 +xref: neuronames:2339 xref: SCTID:279318005 xref: UMLS:C0010097 {source="ncithesaurus:Corpus_Striatum"} xref: VHOG:0001175 @@ -205364,6 +307490,7 @@ id: UBERON:0000375 name: mandibular nerve namespace: uberon def: "The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini." [MP:0009800, Wikipedia:Mandibular_nerve] +subset: human_reference_atlas subset: pheno_slim synonym: "inferior maxillary nerve" EXACT [FMA:52996] synonym: "mandibular division [V3]" EXACT [FMA:52996] @@ -205400,6 +307527,7 @@ xref: Wikipedia:Mandibular_nerve is_a: UBERON:0011779 ! nerve of head region relationship: branching_part_of UBERON:0001645 ! trigeminal nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000376 @@ -205441,6 +307569,10 @@ xref: VHOG:0000349 xref: Wikipedia:Thigh is_a: UBERON:0002472 ! stylopod is_a: UBERON:0008784 ! lower limb segment +intersection_of: UBERON:0002472 ! stylopod +intersection_of: part_of UBERON:0002103 ! hindlimb +relationship: contributes_to_morphology_of UBERON:0002103 ! hindlimb +relationship: has_skeleton UBERON:0015052 ! femur endochondral element relationship: part_of UBERON:0000978 {source="MA"} ! leg property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4b/Gray1238.png xsd:anyURI property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000349", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} @@ -205451,6 +307583,7 @@ id: UBERON:0000377 name: maxillary nerve namespace: uberon def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve] +subset: human_reference_atlas subset: pheno_slim synonym: "maxillary division [V2]" EXACT [FMA:52724] synonym: "maxillary division [Vb]" EXACT [FMA:52724] @@ -205483,6 +307616,7 @@ xref: Wikipedia:Maxillary_nerve is_a: UBERON:0011779 ! nerve of head region relationship: branching_part_of UBERON:0001645 ! trigeminal nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Medial ramus (sensory) of the trigeminal nerve.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000002 "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO"} @@ -205511,6 +307645,7 @@ xref: UMLS:C0448325 {source="ncithesaurus:Tongue_Muscle"} xref: UMLS:C1710437 {source="ncithesaurus:Tongue_Skeletal_Muscle_Tissue"} xref: VHOG:0001390 xref: Wikipedia:Muscles_of_tongue +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010959 ! craniocervical muscle is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0014892 ! skeletal muscle organ @@ -205562,6 +307697,7 @@ id: UBERON:0000381 name: urinary bladder detrusor smooth muscle namespace: uberon def: "Bundles of smooth muscle fibers forming the muscular wall of the urinary bladder, which are arranged in a longitudinal and a circular layer and, on contraction, serve to expel urine[MP]." [MP:0011774, Wikipedia:Detrusor_urinae_muscle] +subset: human_reference_atlas subset: pheno_slim synonym: "detrusor" EXACT [FMA:68018] synonym: "detrusor muscle" EXACT [BTO:0001453] @@ -205583,7 +307719,15 @@ xref: SCTID:279414008 xref: Wikipedia:Detrusor_urinae_muscle is_a: UBERON:0004228 ! urinary bladder smooth muscle relationship: part_of UBERON:0012378 {source="FMA"} ! muscle layer of urinary bladder -property_value: depicted:by Illu:bladder.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0000382 +name: apocrine sweat gland +is_a: UBERON:0001820 ! sweat gland +is_a: UBERON:0010243 ! merocrine gland +disjoint_from: UBERON:0000423 ! eccrine sweat gland [Term] id: UBERON:0000383 @@ -205613,7 +307757,6 @@ xref: MAT:0000025 xref: MIAA:0000025 xref: VSAO:0000033 xref: XAO:0004042 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision @@ -205638,7 +307781,7 @@ xref: EHDAA2:0004081 xref: EMAPA:18289 xref: FMA:55130 xref: GAID:111 -xref: MESH:A02.165.507.411 +xref: MESH:D004825 xref: NCIT:C12709 xref: OpenCyc:Mx4rvVjxE5wpEbGdrcN5Y29ycA xref: SCTID:245502004 @@ -205647,6 +307790,8 @@ xref: Wikipedia:Epiglottis is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013522 ! subdivision of tube relationship: develops_from UBERON:0003115 {source="EHDAA2"} ! pharyngeal arch 4 +relationship: has_component UBERON:0001742 ! epiglottic cartilage +relationship: has_component UBERON:0004982 ! mucosa of epiglottis relationship: part_of UBERON:0001051 ! hypopharynx property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e2/Gray958.png xsd:anyURI property_value: RO:0002161 NCBITaxon:8782 @@ -205658,12 +307803,14 @@ name: lens cortex namespace: uberon def: "Tissue that surrounds the lens nucleus" [http://www.thefreedictionary.com/lens+cortex] def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex] +subset: human_reference_atlas synonym: "cortex of lens" EXACT [FMA:58970] xref: BTO:0001632 xref: CALOHA:TS-0542 xref: FMA:58970 xref: http://www.snomedbrowser.com/Codes/Details/280626006 xref: MESH:A09.371.509.225 +xref: MESH:D007904 xref: SCTID:280626006 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure @@ -205673,17 +307820,20 @@ intersection_of: surrounds UBERON:0000390 ! lens nucleus relationship: develops_from UBERON:0005614 ! lens anterior epithelium relationship: part_of UBERON:0000965 ! lens of camera-type eye relationship: surrounds UBERON:0000390 ! lens nucleus +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000390 name: lens nucleus namespace: uberon def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633] +subset: human_reference_atlas synonym: "nucleus of lens" EXACT [FMA:58971] xref: BTO:0001633 xref: FMA:58971 xref: http://www.snomedbrowser.com/Codes/Details/280628007 xref: MESH:A09.371.509.670 +xref: MESH:D007907 xref: SCTID:280628007 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -205693,6 +307843,7 @@ intersection_of: surrounded_by UBERON:0000389 ! lens cortex relationship: develops_from UBERON:0005614 ! lens anterior epithelium relationship: part_of UBERON:0000965 ! lens of camera-type eye relationship: surrounded_by UBERON:0000389 ! lens cortex +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000391 @@ -205708,8 +307859,8 @@ synonym: "pia-arachnoid of neuraxis" RELATED [FMA:231515] xref: BTO:0001634 xref: CALOHA:TS-0546 xref: FMA:231515 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2347 xref: NCIT:C32979 +xref: neuronames:2347 xref: NLXANAT:090207 xref: SCTID:362303006 xref: UMLS:C0228126 {source="ncithesaurus:Leptomeninges"} @@ -205760,14 +307911,18 @@ xref: EHDAA2:0002198 xref: EMAPA:17572 xref: FMA:53445 xref: GAID:722 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1405 xref: MA:0001085 xref: MESH:D013136 +xref: neuronames:1405 xref: SCTID:368955007 xref: VHOG:0001183 xref: Wikipedia:Spiral_ganglion is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001714 ! cranial ganglion +intersection_of: extends_fibers_into UBERON:0004727 ! cochlear nerve +relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve +relationship: located_in UBERON:0006723 ! cochlear modiolus relationship: part_of UBERON:0002827 ! vestibulocochlear ganglion relationship: part_of UBERON:0016490 ! auditory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray903.png xsd:anyURI @@ -205806,6 +307961,7 @@ id: UBERON:0000397 name: colonic epithelium namespace: uberon def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: vertebrate_core synonym: "colon epithelial tissue" EXACT [OBOL:automatic] synonym: "colon epithelium" EXACT [FMA:17302] @@ -205823,12 +307979,14 @@ xref: EMAPA:18941 xref: FMA:17302 xref: http://www.snomedbrowser.com/Codes/Details/42978003 xref: MA:0003195 +xref: SCTID:42978003 xref: TAO:0005128 xref: ZFA:0005128 is_a: UBERON:0001278 ! epithelium of large intestine intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Intestinal epithelium which lines the lumen of the posterior intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005128", ontology="TAO", source="ZFIN:curator"} [Term] @@ -205841,6 +307999,8 @@ synonym: "cartilage of sternum" EXACT [FMA:32567] xref: FMA:32567 is_a: UBERON:0002418 ! cartilage tissue is_a: UBERON:0003837 ! thoracic segment connective tissue +intersection_of: UBERON:0002418 ! cartilage tissue +intersection_of: part_of UBERON:0000975 ! sternum relationship: part_of UBERON:0000975 ! sternum [Term] @@ -205848,6 +308008,7 @@ id: UBERON:0000399 name: jejunal mucosa namespace: uberon def: "A mucosa that is part of a jejunum [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "jejunal mucous membrane" EXACT [FMA:14949] synonym: "jejunum mucosa" EXACT [FMA:14949] synonym: "jejunum mucosa of organ" EXACT [OBOL:automatic] @@ -205864,7 +308025,18 @@ xref: FMA:14949 xref: MA:0003214 xref: SCTID:362151009 is_a: UBERON:0001204 ! mucosa of small intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0000400 +name: jejunal epithelium +is_a: UBERON:0013636 ! epithelium of intestinal villus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002115 ! jejunum +relationship: part_of UBERON:0008343 ! intestinal villus of jejunum [Term] id: UBERON:0000401 @@ -205889,6 +308061,13 @@ is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001684 ! mandible property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png xsd:anyURI +[Term] +id: UBERON:0000402 +name: nasal vestibule +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +relationship: part_of UBERON:0001707 ! nasal cavity + [Term] id: UBERON:0000407 name: sympathetic trunk @@ -205970,14 +308149,16 @@ xref: FMA:62652 xref: SCTID:30802009 is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] id: UBERON:0000411 name: visual cortex namespace: uberon -def: "The part of the cerebral cortex responsible for processing visual information." [Wikipedia:Visual_cortex] -comment: The visual cortex is made up of Brodmann area 17 (the primary visual cortex), and Brodmann area 18 and Brodmann area 19, the extrastriate cortical areas. +def: "The part of the occipital lobe responsible for processing visual information." [Wikipedia:Visual_cortex] +comment: The visual cortex is made up of Brodmann area 17 (the primary visual cortex), and Brodmann area 18 and Brodmann area 19, the extrastriate cortical areas, in humans. subset: efo_slim synonym: "higher-order visual cortex" RELATED [FMA:242644] synonym: "visual areas" RELATED [BAMS:VIS] @@ -205989,13 +308170,12 @@ xref: EMAPA:36446 xref: EV:0100171 xref: FMA:242644 xref: GAID:679 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1911 xref: MBA:669 -xref: MESH:A08.186.211.730.885.213.571.735 +xref: MESH:D014793 +xref: neuronames:1911 xref: Wikipedia:Visual_cortex -is_a: UBERON:0010314 ! structure with developmental contribution from neural crest -is_a: UBERON:0035014 {source="cjm"} ! functional part of brain -relationship: part_of UBERON:0016540 {source="tgbugs"} ! occipital cortex +is_a: UBERON:8440011 ! cortical visual area +relationship: part_of UBERON:0002021 ! occipital lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/70/Brodmann_areas_17_18_19.png xsd:anyURI [Term] @@ -206052,6 +308232,10 @@ xref: FMA:62888 xref: Mucous:gland xref: Wikipedia:Mucous_gland is_a: UBERON:0002365 ! exocrine gland +intersection_of: UBERON:0002365 ! exocrine gland +intersection_of: has_part CL:0000319 ! mucus secreting cell +relationship: capable_of GO:0070254 ! mucus secretion +relationship: has_part CL:0000319 ! mucus secreting cell relationship: produces UBERON:0000912 ! mucus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png xsd:anyURI property_value: UBPROP:0000008 "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" xsd:string {scope="NCBITaxon:8292", source="ISBN:0073040584"} @@ -206088,6 +308272,7 @@ id: UBERON:0000423 name: eccrine sweat gland namespace: uberon def: "A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Eccrine_sweat_gland] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "eccrine gland" RELATED [FMA:59154] @@ -206105,6 +308290,7 @@ xref: UMLS:C0013492 {source="ncithesaurus:Eccrine_Sweat_Gland"} xref: Wikipedia:Eccrine_sweat_gland is_a: UBERON:0001820 ! sweat gland is_a: UBERON:0010243 {source="MGI:anna"} ! merocrine gland +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in mice, found only on footpads; in humans, entire body including soles and palms" xsd:string [Term] @@ -206113,6 +308299,7 @@ name: prostate epithelium namespace: uberon alt_id: UBERON:0002452 def: "The prostate epithelium." [MP:0001168] +subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of prostate" EXACT [OBOL:automatic] synonym: "epithelial tissue of prostate gland" EXACT [OBOL:automatic] @@ -206137,8 +308324,11 @@ is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland property_value: editor_note "TODO - check 2 FMA IDs" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000429 @@ -206159,6 +308349,16 @@ is_a: UBERON:0001816 ! autonomic nerve plexus is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0002005 ! enteric nervous system +[Term] +id: UBERON:0000439 +name: arachnoid trabecula +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0002362 ! arachnoid mater +relationship: has_part GO:0005581 ! collagen trimer +relationship: part_of UBERON:0002362 ! arachnoid mater + [Term] id: UBERON:0000440 name: trabecula @@ -206166,12 +308366,34 @@ namespace: uberon def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula] subset: grouping_class subset: pheno_slim +synonym: "trabeculae" EXACT PLURAL [] xref: BTO:0002501 xref: FMA:85273 xref: Wikipedia:Trabecula is_a: UBERON:0000064 ! organ part +relationship: has_part UBERON:0002384 ! connective tissue +relationship: has_quality PATO:0001873 ! cylindrical property_value: UBPROP:0000007 "trabecular" xsd:string +[Term] +id: UBERON:0000442 +name: right testicular vein +is_a: UBERON:0001144 ! testicular vein +intersection_of: UBERON:0001144 ! testicular vein +intersection_of: drains UBERON:0004534 ! right testis +relationship: connected_to UBERON:0001142 ! left renal vein +relationship: drains UBERON:0004534 ! right testis +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0000443 +name: left testicular vein +is_a: UBERON:0001144 ! testicular vein +intersection_of: UBERON:0001144 ! testicular vein +intersection_of: drains UBERON:0004533 ! left testis +relationship: drains UBERON:0004533 ! left testis +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + [Term] id: UBERON:0000444 name: lymphoid follicle @@ -206180,7 +308402,7 @@ def: "." [https://github.com/obophenotype/uberon/issues/6, https://github.com/ob synonym: "folliculus lymphaticus" RELATED [BTO:0002684] synonym: "lymphatic follicle" RELATED [BTO:0002684] synonym: "lymphatic nodule" RELATED [BTO:0002684] -synonym: "lymphoid nodule" EXACT [FMA:55222] +synonym: "lymphoid nodule" RELATED [FMA:55222] synonym: "nodular lymphoid tissue" EXACT [FMA:55222] synonym: "nodulus lymphaticus" RELATED [BTO:0002684] synonym: "nodulus lymphoideus" RELATED [BTO:0002684] @@ -206217,9 +308439,8 @@ xref: BM:Tel-Spt xref: BTO:0002705 xref: EMAPA:32837 xref: FMA:61842 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=255 {source="BIRNLEX:963"} xref: MA:0000924 -xref: MESH:A08.186.211.577.750 +xref: neuronames:255 {source="BIRNLEX:963"} xref: UMLS:C0752060 {source="BIRNLEX:963"} is_a: UBERON:0005401 ! cerebral hemisphere gray matter property_value: UBPROP:0000001 "Subdivision of the telencephalon on the midline between the lateral ventricles which contains the septum pellucidum and the septal nuclei[FMA][FMA:61842]." xsd:string {source="FMA:61842"} @@ -206286,7 +308507,6 @@ xref: MA:0002504 xref: MESH:D012634 xref: NCIT:C34062 xref: UMLS:C1516992 {source="ncithesaurus:Exocrine_Gland_Fluid_or_Secretion"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0002365 ! exocrine gland @@ -206311,6 +308531,17 @@ intersection_of: supplies UBERON:0001675 ! trigeminal ganglion relationship: branching_part_of UBERON:0001532 ! internal carotid artery relationship: supplies UBERON:0001675 ! trigeminal ganglion +[Term] +id: UBERON:0000458 +name: endocervix +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000064 ! organ part +intersection_of: proximalmost_part_of UBERON:0000002 ! uterine cervix +relationship: has_part UBERON:0000485 ! simple columnar epithelium +relationship: proximalmost_part_of UBERON:0000002 ! uterine cervix + [Term] id: UBERON:0000459 name: uterine wall @@ -206326,6 +308557,8 @@ xref: SCTID:245485002 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] @@ -206358,6 +308591,8 @@ is_a: UBERON:0011826 ! vestibular gland is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0019319 ! exocrine gland of integumental system relationship: develops_from UBERON:0000164 {source="Wikipedia"} ! primitive urogenital sinus +relationship: in_lateral_side_of UBERON:0005056 ! external female genitalia +relationship: sexually_homologous_to UBERON:0002366 ! bulbo-urethral gland property_value: editor_note "resolve difference in WP vs MP, superficial vs deep perineal pouch" xsd:string [Term] @@ -206365,6 +308600,7 @@ id: UBERON:0000463 name: organism substance namespace: uberon def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737] +def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [] subset: pheno_slim subset: upper_level synonym: "body fluid or substance" EXACT [MA:0002450] @@ -206391,10 +308627,11 @@ xref: TGMA:0001824 xref: VHOG:0001726 xref: XAO:0004001 xref: ZFA:0001487 -is_a: BFO:0000004 ! independent continuant +is_a: FOODON:03420122 ! nonmeat part of animal is_a: UBERON:0000465 ! material anatomical entity relationship: has_quality PATO:0002198 ! quality of a substance relationship: part_of UBERON:0000468 {notes="this relationship may be too strong and may be weakened in future"} ! multicellular organism +relationship: produced_by OBI:0100026 ! organism [Term] id: UBERON:0000464 @@ -206422,8 +308659,8 @@ xref: UMLS:C0524461 {source="ncithesaurus:Lumen_Space"} xref: VHOG:0001728 xref: XAO:0003190 xref: ZFA:0001643 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000466 ! immaterial anatomical entity +disjoint_from: UBERON:0006800 ! anatomical line relationship: surrounded_by UBERON:0000061 ! anatomical structure [Term] @@ -206443,6 +308680,7 @@ xref: HAO:0000006 xref: TAO:0001836 xref: TGMA:0001826 xref: VHOG:0001721 +is_a: BFO:0000040 ! material entity is_a: UBERON:0001062 ! anatomical entity [Term] @@ -206509,7 +308747,6 @@ xref: WBbt:0005763 xref: Wikipedia:Organ_system xref: XAO:0003002 xref: ZFA:0001439 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000061 ! anatomical structure relationship: existence_starts_during_or_after UBERON:0000111 ! organogenesis stage relationship: has_part UBERON:0000062 ! organ @@ -206531,7 +308768,9 @@ synonym: "body" RELATED [AEO:0000103, BIRNLEX:18, FMA:256135, NCIT:C13041] synonym: "Koerper" RELATED [BTO:0001489] synonym: "multi-cellular organism" EXACT [CARO:0000012] synonym: "organism" BROAD [FBbt:00000001, VHOG:0000671, WBbt:0007833] +synonym: "organism" EXACT [] synonym: "whole body" RELATED [BTO:0001489] +synonym: "whole organism" EXACT [] synonym: "whole organism" RELATED [FBbt:00000001] xref: AAO:0010026 xref: AEO:0000191 @@ -206565,6 +308804,7 @@ xref: XAO:0003004 xref: ZFA:0001094 is_a: UBERON:0010000 ! multicellular anatomical structure property_value: editor_note "TODO - split body and mc organism? body continues after death stage" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl property_value: UBPROP:0000007 "organismal" xsd:string [Term] @@ -206637,6 +308877,10 @@ xref: XAO:0000157 xref: ZFA:0000598 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003135 ! male reproductive organ +intersection_of: UBERON:0000991 ! gonad +intersection_of: part_of UBERON:0000079 ! male reproductive system +disjoint_from: UBERON:0000992 ! ovary +disjoint_from: UBERON:0009117 ! indifferent gonad relationship: develops_from UBERON:0009117 ! indifferent gonad property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png xsd:anyURI property_value: UBPROP:0000001 "Male reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000598", ontology="TAO", source="ZFIN:curator"} @@ -206923,7 +309167,7 @@ xref: XAO:0003163 xref: ZFA:0001485 is_a: UBERON:0005764 {source="FMA"} ! acellular membrane relationship: part_of UBERON:0005769 {source="FMA"} ! basement membrane of epithelium -property_value: depicted:by Basal:lamina.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/65/Basal_lamina.jpg xsd:anyURI property_value: IAO:0000232 "this class represents a continuous sheet of basal lamina which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal lamina' represents a portion of substance on the scale of a single cell." xsd:string property_value: UBPROP:0000003 "A basal lamina is certainly present in Bilateria and was evaluated as an autapomorphy of this taxon.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001592", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.57", source="http://bgee.unil.ch/"} @@ -206965,7 +309209,6 @@ xref: VHOG:0000387 xref: Wikipedia:Epithelium xref: XAO:0003045 xref: ZFA:0001486 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of CL:0000066 ! epithelial cell @@ -206975,6 +309218,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell relationship: has_part GO:0005911 ! cell-cell junction relationship: has_part UBERON:0005769 ! basement membrane of epithelium relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg xsd:anyURI property_value: depicted:by Tkanka:nablonkowa.png xsd:anyURI property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59"} @@ -207107,6 +309351,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: has_part CL:0000076 ! squamous epithelial cell +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg xsd:anyURI property_value: depicted:by Illu:epithelium.jpg xsd:anyURI property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="http://orcid.org/0000-0001-9114-8737", source="FMA:45565"} property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"} @@ -207192,7 +309437,6 @@ property_value: UBPROP:0000001 "Epithelium that consists of a single layer of ep id: UBERON:0000908 name: hippocampal commissure namespace: uberon -alt_id: UBERON:Commissure-MA_0002723 def: "The triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side." [ISBN:0-683-40008-8, MP:0008221] subset: pheno_slim subset: uberon_slim @@ -207218,9 +309462,9 @@ xref: DMBA:17769 xref: EMAPA:35404 xref: FMA:61970 xref: HBA:9228 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=273 xref: MA:0002723 xref: MBA:618 +xref: neuronames:273 xref: SCTID:369115003 xref: UMLS:C0228287 {source="BIRNLEX:746"} xref: Wikipedia:Commissure_of_fornix @@ -207233,6 +309477,7 @@ id: UBERON:0000912 name: mucus namespace: uberon def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [http://en.wikipedia.org/wiki/Mucus] +def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus] xref: CALOHA:TS-2144 xref: ENVO:02000040 xref: FMA:66938 @@ -207244,8 +309489,11 @@ xref: MESH:D009093 xref: NCIT:C13259 xref: OpenCyc:Mx4rvVjHq5wpEbGdrcN5Y29ycA xref: UMLS:C0026727 {source="ncithesaurus:Mucus"} +xref: Wikipedia:Mucus is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid +relationship: has_part CHEBI:37395 ! mucopolysaccharide +relationship: has_quality PATO:0000998 ! viscous relationship: produced_by UBERON:0000344 ! mucosa property_value: UBPROP:0000007 "mucoid" xsd:string property_value: UBPROP:0000007 "mucous" xsd:string @@ -207263,7 +309511,9 @@ xref: FMA:9673 xref: NCIT:C120839 xref: Wikipedia:Interstitial_fluid is_a: UBERON:0000463 ! organism substance +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000479 ! tissue +relationship: surrounds CL:0000000 ! cell property_value: RO:0002171 UBERON:0001969 [Term] @@ -207300,6 +309550,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/302551006 xref: MA:0000022 xref: SCTID:302551006 xref: Wikipedia:Thorax +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis @@ -207336,12 +309587,13 @@ xref: http://www.snomedbrowser.com/Codes/Details/302553009 xref: MA:0000029 xref: MAT:0000298 xref: MESH:A01.047 +xref: MESH:D000005 xref: MIAA:0000298 xref: OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA xref: SCTID:302553009 xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002417 {source="MA"} ! abdominal segment of trunk property_value: editor_note "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" xsd:string property_value: UBPROP:0000007 "abdominal" xsd:string @@ -207397,6 +309649,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage intersection_of: existence_starts_with UBERON:0000068 ! embryo stage relationship: existence_ends_with UBERON:0000068 ! embryo stage relationship: existence_starts_with UBERON:0000068 ! embryo stage +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg xsd:anyURI property_value: depicted:by Wrinkledfrog:embryos.jpg xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/503 xsd:anyURI property_value: UBPROP:0000007 "embryonic" xsd:string @@ -207427,6 +309680,7 @@ xref: Germ:layer xref: http://linkedlifedata.com/resource/umls/id/C0920502 xref: http://linkedlifedata.com/resource/umls/id/C1708239 xref: MESH:A16.254.425 +xref: MESH:D005855 xref: NCIT:C12950 xref: NCIT:C54105 xref: TAO:0001122 @@ -207469,6 +309723,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/362851007 xref: MAT:0000155 xref: MAT:0000173 xref: MESH:A16.254.425.273 +xref: MESH:D004475 xref: MIAA:0000173 xref: NCIT:C12703 xref: SCTID:362851007 @@ -207516,6 +309771,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0014144 xref: http://www.snomedbrowser.com/Codes/Details/362855003 xref: MAT:0000175 xref: MESH:A16.254.425.407 +xref: MESH:D004707 xref: MIAA:0000175 xref: NCIT:C12706 xref: SCTID:362855003 @@ -207569,6 +309825,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0025485 xref: http://www.snomedbrowser.com/Codes/Details/362854004 xref: MAT:0000174 xref: MESH:A16.254.425.660 +xref: MESH:D008648 xref: MIAA:0000174 xref: NCIT:C12750 xref: SCTID:362854004 @@ -207591,6 +309848,14 @@ property_value: UBPROP:0000007 "mesodermal" xsd:string property_value: UBPROP:0000008 "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" xsd:string {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} property_value: UBPROP:0000008 "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" xsd:string {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} +[Term] +id: UBERON:0000929 +name: pharyngeal branch of vagus nerve +is_a: UBERON:0011779 ! nerve of head region +relationship: branching_part_of UBERON:0001759 ! vagus nerve +relationship: extends_fibers_into UBERON:0005363 ! inferior vagus X ganglion +relationship: part_of UBERON:0001005 ! respiratory airway + [Term] id: UBERON:0000930 name: stomodeum @@ -207669,6 +309934,7 @@ relationship: dc-contributor https://github.com/mmc46 relationship: develops_from UBERON:0000924 ! ectoderm relationship: has_potential_to_develop_into UBERON:0001353 ! anal region relationship: located_in UBERON:0012469 {source="EHDAA2"} ! external anal region +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0007026 ! presumptive gut property_value: editor_note "removed WBbt:0006795 'proctodeum' - junction between the alimentary and genital tracts in the male." xsd:string property_value: seeAlso https://github.com/obophenotype/uberon/issues/685 xsd:anyURI @@ -207707,6 +309973,9 @@ xref: UMLS:C0031346 {source="ncithesaurus:Pharyngeal_Muscle"} xref: Wikipedia:Pharyngeal_muscles xref: ZFA:0000172 is_a: UBERON:0001630 ! muscle organ +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: part_of UBERON:0004467 ! musculature of pharynx +relationship: contributes_to_morphology_of UBERON:0001015 ! musculature relationship: part_of UBERON:0004467 ! musculature of pharynx property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/35/Gray1030.png xsd:anyURI property_value: UBPROP:0000001 "A pharyngeal muscle is any muscle that forms part of the pharynx[GO]." xsd:string {date_retrieved="2012-06-30", external_class="GO:0043282", notes="does not quite work for some muscles such as stylopharyngeus", ontology="GO", source="GOC:go_curators"} @@ -207717,6 +309986,7 @@ id: UBERON:0000935 name: anterior commissure namespace: uberon def: "A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris)." [BTO:0002169] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -207742,9 +310012,9 @@ xref: DMBA:17751 xref: EMAPA:19038 xref: FMA:61961 xref: HBA:9221 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=205 xref: MA:0002722 xref: NCIT:C32086 +xref: neuronames:205 xref: NLX:144088 xref: SCTID:279313001 xref: SCTID:369119009 @@ -207757,6 +310027,7 @@ xref: ZFA:0001108 is_a: UBERON:0002473 {source="FMA", source="MA"} ! intercerebral commissure is_a: UBERON:0005341 {source="MP"} ! ventral commissure property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray744.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "In all vertebrates the thin structure that connects the two halves of the telencephalon shows a ridge-like thickening at the basal side known as the anterior commissure.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001558", ontology="VHOG", source="DOI:10.1111/j.1749-6632.1969.tb20432.x", source="http://bgee.unil.ch/"} [Term] @@ -207782,10 +310053,10 @@ xref: DMBA:17787 xref: EMAPA:35695 xref: FMA:62072 xref: HBA:9229 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=484 {source="BIRNLEX:1026"} xref: MA:0002743 xref: MBA:158 xref: NCIT:C33356 +xref: neuronames:484 {source="BIRNLEX:1026"} xref: TAO:0000320 xref: UMLS:C0152327 {source="BIRNLEX:1026"} xref: UMLS:C0152327 {source="ncithesaurus:Posterior_Commissure"} @@ -207807,6 +310078,7 @@ synonym: "imaginal disk" RELATED [] xref: BTO:0004658 xref: FBbt:00001761 xref: MAT:0000064 +xref: MESH:D060227 xref: MIAA:0000064 xref: Wikipedia:Imaginal_disc is_a: UBERON:0007499 {source="FBbt text definition"} ! epithelial sac @@ -207848,11 +310120,11 @@ xref: EMAPA:17575 xref: FMA:50863 xref: GAID:831 xref: HBA:9307 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=289 {source="BIRNLEX:1640"} xref: MA:0001097 xref: MBA:848 xref: MESH:D009900 xref: NCIT:C12761 +xref: neuronames:289 {source="BIRNLEX:1640"} xref: OpenCyc:Mx4rvVjLm5wpEbGdrcN5Y29ycA xref: SCTID:180938001 xref: TAO:0000435 @@ -207862,9 +310134,16 @@ xref: VHOG:0000543 xref: Wikipedia:Optic_nerve xref: XAO:0000188 xref: ZFA:0000435 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: extends_fibers_into UBERON:0000959 ! optic chiasma +intersection_of: innervates UBERON:0000966 ! retina relationship: develops_from UBERON:0003902 {source="EHDAA2"} ! retinal neural layer +relationship: extends_fibers_into UBERON:0000959 ! optic chiasma +relationship: extends_fibers_into UBERON:0003098 ! optic stalk +relationship: innervates UBERON:0000966 ! retina relationship: part_of UBERON:0002104 ! visual system property_value: editor_note "Do not classify under 'cranial nerve', as this is not a true nerve - should be classified as evaginated sensory afferent[ISBN:0471888893]" xsd:string property_value: UBPROP:0000001 "A collection of nerve cells that project visual information from the eyes to the brain. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000435", ontology="TAO", source="ZFIN:curator"} @@ -207902,7 +310181,7 @@ xref: GAID:293 xref: galen:Stomach xref: MA:0000353 xref: MAT:0000051 -xref: MESH:A03.492.766 +xref: MESH:D013270 xref: MIAA:0000051 xref: NCIT:C12391 xref: OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA @@ -207918,7 +310197,7 @@ relationship: capable_of GO:0001696 {evidence="ISBN:0486692132"} ! gastric acid relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system relationship: only_in_taxon NCBITaxon:7776 {notes="absent in lampreys and hagfishes", source="ISBN:0073040584"} ! Gnathostomata relationship: part_of UBERON:0001041 ! foregut -property_value: depicted:by Stomach:diagram.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:7864 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7878 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:7955 {source="ZFA"} @@ -207932,6 +310211,7 @@ id: UBERON:0000946 name: cardial valve namespace: uberon def: "A membranous fold of the heart that prevents reflux of fluid." [MESH:A07.541.510, MP:0000285, PMID:7926784] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -207964,6 +310244,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0002062 {source="PMID:15797462"} ! endocardial cushion relationship: part_of UBERON:0000948 ! heart +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "One of the four structures within the heart that prevent backflow of blood by opening and closing with each heartbeat. The valves include two semilunar valves, the aortic and pulmonary; the mitral or bicuspid valve; and the tricuspid valve. The valves permit blood flow in only one direction. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000818", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/heart+valve"} property_value: UBPROP:0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000818", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "Rector et al: One might be tempted to define 'heart valve' equivalently to 'valve in the heart', and 'valve' as a 'structure which functions as a valve'. But this combination results in the 'foramen ovale' being classified as a kind of 'heart valve', since it is undoubtedly located in the heart and functions as a valve" xsd:string @@ -207975,6 +310256,7 @@ namespace: uberon def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta] subset: efo_slim subset: grouping_class +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria maxima" RELATED LATIN [Wikipedia:Aorta] @@ -208004,9 +310286,11 @@ xref: XAO:0003010 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel is_a: UBERON:0003519 ! thoracic cavity blood vessel is_a: UBERON:0013768 ! great vessel of heart +relationship: connected_to UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0010191 {source="EHDAA2"} ! aortic system -property_value: depicted:by Aorta:scheme.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg xsd:anyURI property_value: editor_note "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." xsd:string {source="WP"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010213", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001523", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "aortic" xsd:string @@ -208020,6 +310304,7 @@ def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascul def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart] comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -208067,10 +310352,11 @@ intersection_of: has_part UBERON:0004151 ! cardiac chamber relationship: contributes_to_morphology_of UBERON:0004535 ! cardiovascular system relationship: develops_from UBERON:0004141 ! heart tube relationship: has_part UBERON:0004151 ! cardiac chamber -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0015410 {source="MA"} ! heart plus pericardium property_value: RO:0002161 NCBITaxon:6239 property_value: RO:0002161 NCBITaxon:7227 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000114", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO"} @@ -208115,15 +310401,18 @@ intersection_of: capable_of GO:0050886 ! endocrine process disjoint_from: UBERON:0000990 ! reproductive system disjoint_from: UBERON:0001004 ! respiratory system disjoint_from: UBERON:0001007 ! digestive system +disjoint_from: UBERON:0001008 ! renal system disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0050886 ! endocrine process relationship: composed_primarily_of UBERON:0002368 ! endocrine gland @@ -208133,6 +310422,19 @@ property_value: UBPROP:0000001 "Anatomical system containing glands which regula property_value: UBPROP:0000003 "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000098", ontology="VHOG", source="DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "endocrine" xsd:string +[Term] +id: UBERON:0000951 +name: rotator muscle of the vertebral column +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0001630 ! muscle organ +is_a: UBERON:0005174 ! dorsal region element +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: has_muscle_insertion UBERON:0001076 ! neural spine +intersection_of: has_muscle_origin UBERON:0001077 ! transverse process of vertebra +intersection_of: part_of UBERON:0001137 ! dorsum +relationship: has_muscle_insertion UBERON:0001076 ! neural spine +relationship: has_muscle_origin UBERON:0001077 ! transverse process of vertebra + [Term] id: UBERON:0000955 name: brain @@ -208141,6 +310443,7 @@ def: "The brain is the center of the nervous system in all vertebrate, and most def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [http://en.wikipedia.org/wiki/Brain, https://github.com/obophenotype/uberon/issues/300] subset: cumbo subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim @@ -208183,6 +310486,7 @@ xref: MBA:997 xref: MESH:D001921 xref: MIAA:0000098 xref: NCIT:C12439 +xref: neuronames:21 {source="BIRNLEX:796"} xref: OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA xref: PBA:3999 xref: SCTID:258335003 @@ -208206,6 +310510,7 @@ relationship: immediate_transformation_of UBERON:0006238 {source="Bgee:AN"} ! fu relationship: in_anterior_side_of UBERON:0000468 ! multicellular organism relationship: part_of UBERON:0001017 {source="FMA"} ! central nervous system property_value: editor_note "requires review for applicability to invertebrate structures, e.g. synganglion" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000008", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010478", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)" xsd:string {source="Cumbo:terms"} @@ -208219,6 +310524,7 @@ name: cerebral cortex namespace: uberon def: "The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex." [BIRNLEX:1494] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brain cortex" RELATED [BTO:0000233] @@ -208245,13 +310551,13 @@ xref: EV:0100166 xref: FMA:61830 xref: GAID:629 xref: HBA:4008 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39 {source="BIRNLEX:1494"} xref: MA:0000185 xref: MAT:0000108 xref: MBA:688 -xref: MESH:A08.186.211.730.885.213 +xref: MESH:D002540 xref: MIAA:0000108 xref: NCIT:C12443 +xref: neuronames:39 {source="BIRNLEX:1494"} xref: PBA:128011354 xref: SCTID:362880003 xref: UMLS:C0007776 {source="BIRNLEX:1494"} @@ -208270,6 +310576,7 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7b/C property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg xsd:anyURI property_value: IAO:0000232 "We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus)." xsd:string property_value: RO:0002175 NCBITaxon:117569 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]." xsd:string {source="Wikipedia:Cerebral_cortex"} property_value: UBPROP:0000003 "Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000722", ontology="VHOG", source="DOI:10.1111/j.1749-6632.1969.tb20437.x Kruger L, Experimental analyses of the reptilian nervous system. Annals of the New York Academy of Sciences (1969)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743]" xsd:string @@ -208302,6 +310609,8 @@ synonym: "medulla" EXACT [FMA:61108] xref: FMA:61108 xref: galen:Medulla is_a: UBERON:0000471 ! compound organ component +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: surrounded_by UBERON:0001851 ! cortex property_value: IAO:0000232 "this class is used in a very general sense" xsd:string property_value: UBPROP:0000007 "medullary" xsd:string @@ -208334,11 +310643,11 @@ xref: EMAPA:17603 xref: FMA:62045 xref: GAID:832 xref: HBA:9310 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=459 {source="BIRNLEX:1416"} xref: MA:0001098 xref: MBA:117 xref: MESH:D009897 xref: NCIT:C90609 +xref: neuronames:459 {source="BIRNLEX:1416"} xref: SCTID:244453006 xref: TAO:0000556 xref: UMLS:C0029126 {source="BIRNLEX:1416"} @@ -208348,6 +310657,12 @@ xref: Wikipedia:Optic_chiasm xref: XAO:0004071 xref: ZFA:0000556 is_a: UBERON:0007425 ! decussation of diencephalon +intersection_of: UBERON:0007418 ! neural decussation +intersection_of: extends_fibers_into UBERON:0000941 ! cranial nerve II +intersection_of: extends_fibers_into UBERON:0001908 ! optic tract +intersection_of: part_of UBERON:0001894 ! diencephalon +relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II +relationship: extends_fibers_into UBERON:0001908 ! optic tract property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg xsd:anyURI property_value: UBPROP:0000001 "The point at which fibers of the optic nerves cross.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010622", ontology="AAO", source="AAO:DSM"} property_value: UBPROP:0000003 "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000190", ontology="VHOG", source="DOI:10.1016/j.preteyeres.2005.04.005 Jeffery G, Erskine L, Variations in the architecture and development of the vertebrate optic chiasm. Progress in retinal and eye research (2005)", source="http://bgee.unil.ch/"} @@ -208365,8 +310680,8 @@ synonym: "cervical spinal nerve" EXACT [] synonym: "nervus cervicalis" EXACT LATIN [FMA:5859, FMA:TA] xref: BAMS:cern xref: FMA:5859 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2351 xref: NCIT:C32299 +xref: neuronames:2351 xref: NLXANAT:20090207 xref: SCTID:360497008 xref: UMLS:C0228815 {source="ncithesaurus:Cervical_Nerve"} @@ -208397,6 +310712,7 @@ namespace: uberon def: "the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure" [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -208427,6 +310743,7 @@ xref: VHOG:0000164 xref: Wikipedia:Cornea xref: XAO:0000180 xref: ZFA:0000640 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0003102 {source="XAO"} ! surface structure is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure @@ -208442,6 +310759,7 @@ relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "corneal" xsd:string property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string @@ -208452,6 +310770,7 @@ namespace: uberon def: "Transparent part of camera-type eye that helps to refract light to be focused on the retina." [http://en.wikipedia.org/wiki/Lens_(anatomy), http://orcid.org/0000-0002-6601-2165] def: "Transparent part of camera-type eye that helps to refract light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)] comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -208476,6 +310795,7 @@ xref: Lens:(anatomy) xref: MA:0000275 xref: MAT:0000141 xref: MESH:A09.371.509 +xref: MESH:D007908 xref: MIAA:0000141 xref: NCIT:C12743 xref: OpenCyc:Mx4rvVj0fZwpEbGdrcN5Y29ycA @@ -208487,6 +310807,7 @@ xref: VHOG:0000169 xref: Wikipedia:Lens_(anatomy) xref: XAO:0000008 xref: ZFA:0000035 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005389 ! transparent eye structure relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball @@ -208494,6 +310815,7 @@ relationship: developmentally_induced_by UBERON:0003902 ! retinal neural layer relationship: develops_from UBERON:0005426 ! lens vesicle relationship: part_of UBERON:0001801 ! anterior segment of eyeball property_value: RO:0002171 UBERON:0002049 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000169", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000169", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)"} property_value: UBPROP:0000008 "This class excludes compound eye corneal lenses." xsd:string @@ -208506,6 +310828,7 @@ def: "The retina is the innermost layer or coating at the back of the eyeball, w def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [http://en.wikipedia.org/wiki/Retina, ZFIN:curator] comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -208537,6 +310860,7 @@ xref: MBA:304325711 xref: MESH:D012160 xref: MIAA:0000142 xref: NCIT:C12343 +xref: neuronames:1862 xref: NIFSTD_RETIRED:birnlex_1156 xref: OpenCyc:Mx4rvViTfpwpEbGdrcN5Y29ycA xref: SCTID:181171005 @@ -208558,6 +310882,7 @@ relationship: part_of UBERON:0001802 ! posterior segment of eyeball relationship: part_of UBERON:0019207 ! chorioretinal region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png xsd:anyURI property_value: RO:0002161 NCBITaxon:6656 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)"} @@ -208570,6 +310895,7 @@ namespace: uberon def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim subset: functional_classification +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: uberon_slim @@ -208595,6 +310921,7 @@ relationship: has_part CL:0000149 {source="PMID:21062451"} ! visual pigment cell relationship: has_part CL:0000210 {source="PMID:21062451"} ! photoreceptor cell relationship: part_of UBERON:0002104 ! visual system property_value: IAO:0000232 "This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "ocular" xsd:string property_value: UBPROP:0000007 "optic" xsd:string property_value: UBPROP:0000010 "Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva," xsd:string @@ -208682,6 +311009,7 @@ relationship: only_in_taxon NCBITaxon:8287 ! Sarcopterygii relationship: part_of UBERON:0007811 ! craniocervical region relationship: posteriorly_connected_to UBERON:0002100 ! trunk property_value: depicted:by Female:neck.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg xsd:anyURI property_value: IAO:0000232 "true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck." xsd:string property_value: RO:0002174 NCBITaxon:32443 {source="ISBN:9780674021839"} property_value: UBPROP:0000007 "cervical" xsd:string @@ -208715,6 +311043,10 @@ xref: Wikipedia:Sternum is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0010363 {source="ISBN:0073040584"} ! endochondral element +relationship: connected_to UBERON:0002228 ! rib +relationship: connected_to UBERON:0007831 ! pectoral girdle skeleton +relationship: contributes_to_morphology_of UBERON:0003252 ! thoracic rib cage +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of UBERON:0003252 {source="FMA"} ! thoracic rib cage property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg xsd:anyURI property_value: editor_note "in EMAPA and EHDAA2 this is part of the skeleton of pectoral girdle; the classic def of pectoral girdle (see WP) excludes the rib cage and sternum" xsd:string @@ -208748,7 +311080,7 @@ xref: FMA:13303 xref: GAID:183 xref: galen:Humerus xref: MA:0001356 -xref: MESH:A02.835.232.087.412 +xref: MESH:D006811 xref: NCIT:C12731 xref: SCTID:181923006 xref: UMLS:C0020164 {source="ncithesaurus:Humerus"} @@ -208759,7 +311091,11 @@ is_a: UBERON:0003461 ! shoulder bone is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0004250 ! upper arm bone is_a: UBERON:0015053 ! humerus endochondral element +intersection_of: UBERON:0015053 ! humerus endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0006245 {evidence="definitional"} ! humerus cartilage element +relationship: overlaps UBERON:0001470 ! glenohumeral joint +relationship: proximally_connected_to UBERON:0007831 ! pectoral girdle skeleton property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg xsd:anyURI property_value: UBPROP:0000001 "Paired, elongate, cylindrical bones of endochondral origin that extend from the pectoral girdle to the elbows.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000679", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001158", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} @@ -208805,7 +311141,7 @@ relationship: has_quality PATO:0001748 ! invaginated relationship: only_in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0009778 {source="https://github.com/obophenotype/uberon/issues/86"} ! pleural sac property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png xsd:anyURI -property_value: RO:0002175 NCBITaxon:8782 {source="BGEE:AN", source="ISBN:978-0030223693"} +property_value: RO:0002175 NCBITaxon:8782 {source="ISBN:978-0030223693", source="https://orcid.org/0000-0003-3308-6245"} property_value: UBPROP:0000001 "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000394", ontology="VHOG", source="ISBN:0124020607", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pleural" xsd:string property_value: UBPROP:0000012 "In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86" xsd:string @@ -208837,6 +311173,8 @@ xref: VHOG:0000345 xref: Wikipedia:Leg#Limb is_a: UBERON:0006058 ! multi-limb segment region is_a: UBERON:0008784 ! lower limb segment +relationship: distally_connected_to UBERON:0002387 ! pes +relationship: proximally_connected_to UBERON:0001464 ! hip property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000345", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "The term leg can mean: [1] an appendage on which an animal walks [2] the entire hindlimb of a tetrapod [3] the segment of a human leg between knee and ankle (cf FMA) [4] the region of a hindlimb include the stylopod and zeugopod, but excluding the autopod. We define this class as [4], and thus 'leg' is compltely analagous to 'arm'. For [1], see the class 'locomotive weight-bearing appendage'. For [2] we use 'hindlimb'. For" xsd:string {source="3"} @@ -208859,7 +311197,7 @@ xref: FMA:24476 xref: GAID:204 xref: galen:Tibia xref: MA:0001361 -xref: MESH:A02.835.232.500.883 +xref: MESH:D013977 xref: NCIT:C12800 xref: OpenCyc:Mx4rvtq3-ZwpEbGdrcN5Y29ycA xref: SCTID:182061009 @@ -208868,6 +311206,9 @@ xref: Wikipedia:Tibia is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004251 ! hindlimb zeugopod bone is_a: UBERON:0015004 ! tibia endochondral element +intersection_of: UBERON:0015004 ! tibia endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: BSPO:0001113 UBERON:0010720 ! hindlimb zeugopod skeleton relationship: develops_from UBERON:0010849 ! tibia cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray260.png xsd:anyURI property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a straight, simple bone whose section is more or less rectangular at the ends and circular at its central portion.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000890", ontology="AAO", source="AAO:LAP"} @@ -208920,7 +311261,7 @@ xref: FMA:9611 xref: GAID:199 xref: galen:Femur xref: MA:0001359 -xref: MESH:A02.835.232.500.247 +xref: MESH:D005269 xref: NCIT:C12717 xref: OpenCyc:Mx4rvVjOJJwpEbGdrcN5Y29ycA xref: SCTID:182046008 @@ -208933,7 +311274,10 @@ is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0003826 ! upper leg bone is_a: UBERON:0008202 {source="MA"} ! bone of hip region is_a: UBERON:0015052 ! femur endochondral element +intersection_of: UBERON:0015052 ! femur endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010129 {evidence="definitional"} ! femur cartilage element +relationship: proximally_connected_to UBERON:0007832 ! pelvic girdle skeleton property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/73/Gray252.png xsd:anyURI property_value: UBPROP:0000001 "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000186", ontology="VSAO", source="VSAO:NI"} property_value: UBPROP:0000001 "Paired, elongate, cylindrical bones of endochondral origin that form the thighs, extending from the pelvic girdles to the knees.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000889", ontology="AAO", source="AAO:LAP"} @@ -209010,6 +311354,9 @@ xref: SCTID:280711000 xref: SCTID:370639003 is_a: UBERON:0008784 ! lower limb segment is_a: UBERON:0009877 ! metapodium region +intersection_of: UBERON:0009877 ! metapodium region +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_skeleton UBERON:0010545 ! metatarsus skeleton relationship: part_of UBERON:0012142 {source="PHENOSCAPE:ni"} ! pedal digitopodium region property_value: UBPROP:0000012 "mammalian and non-mammalian AOs differ in whether they consider this a part of the skeleton" xsd:string @@ -209032,12 +311379,22 @@ is_a: UBERON:0000023 ! wing relationship: develops_from UBERON:0000939 ! imaginal disc property_value: editor_note "TODO - review. hymenoptera thorax = fusion of thorax and mesosoma/metasoma" xsd:string +[Term] +id: UBERON:0000985 +name: axillary vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0009472 ! axilla +relationship: drains UBERON:0009472 ! axilla +relationship: part_of UBERON:0001467 ! shoulder + [Term] id: UBERON:0000988 name: pons namespace: uberon def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pons cerebri" RELATED LATIN [NeuroNames:547] @@ -209057,13 +311414,13 @@ xref: EV:0100253 xref: FMA:67943 xref: GAID:578 xref: HBA:9131 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=547 {source="BIRNLEX:733"} xref: MA:0000204 xref: MAT:0000115 xref: MBA:771 xref: MESH:D011149 xref: MIAA:0000115 xref: NCIT:C12511 +xref: neuronames:547 {source="BIRNLEX:733"} xref: SCTID:279103004 xref: UMLS:C0032639 {source="BIRNLEX:733"} xref: UMLS:C0032639 {source="ncithesaurus:Pons_Varolii"} @@ -209074,12 +311431,13 @@ is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: contributes_to_morphology_of UBERON:0001895 ! metencephalon relationship: contributes_to_morphology_of UBERON:0002298 ! brainstem -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001895 {source="neuronames"} ! metencephalon relationship: part_of UBERON:0002298 ! brainstem property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png xsd:anyURI property_value: editor_note "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" xsd:string property_value: RO:0002174 NCBITaxon:7955 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pons"} property_value: UBPROP:0000003 "During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.474", source="http://bgee.unil.ch/"} @@ -209186,10 +311544,12 @@ disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of_part_of GO:0000003 ! reproduction relationship: existence_ends_during UBERON:0000066 ! fully formed stage @@ -209258,6 +311618,7 @@ name: ovary namespace: uberon def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -209320,8 +311681,9 @@ disjoint_from: UBERON:0009117 ! indifferent gonad relationship: develops_from UBERON:0009117 ! indifferent gonad relationship: in_lateral_side_of UBERON:0003975 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA-abduced-lr"} ! internal female genitalia relationship: only_in_taxon NCBITaxon:33208 ! Metazoa -property_value: depicted:by Female:anatomy.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000371", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Female reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000403", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000251", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"} @@ -209362,6 +311724,9 @@ xref: XAO:0003052 xref: ZFA:0000560 is_a: UBERON:0000025 ! tube is_a: UBERON:0005156 ! reproductive structure +relationship: connects UBERON:0000992 ! ovary +relationship: connects UBERON:0013514 ! space surrounding organism +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa relationship: part_of UBERON:0000474 ! female reproductive system property_value: IAO:0000232 "sometimes oviduct is used interchangeably with follaopian tube. Here they are different - the oviduct connects the gonad to the outside in a variety of animals. The mammal-class fallopian tube is derived from the mullerian duct and connects the gonads/infubdibulum to the uterus" xsd:string property_value: UBPROP:0000001 "A passage through which ova leave the maternal body or pass to an organ communicating with the exterior of the body. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001136", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/oviduct"} @@ -209375,6 +311740,7 @@ name: uterus namespace: uberon def: "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." [MGI:csmith, MP:0001120] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -209399,9 +311765,11 @@ xref: Wikipedia:Uterus is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct relationship: immediate_transformation_of UBERON:0005795 ! embryonic uterus +relationship: only_in_taxon NCBITaxon:32525 ! Theria relationship: part_of UBERON:0004175 ! internal genitalia -property_value: depicted:by Female:anatomy.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/uterus"} property_value: UBPROP:0000003 "An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.678", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "uterine" xsd:string @@ -209439,6 +311807,7 @@ xref: VHOG:0001138 xref: Wikipedia:Vagina is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct +relationship: contributes_to_morphology_of UBERON:0003975 ! internal female genitalia relationship: develops_from UBERON:0000164 {source="Wikipedia"} ! primitive urogenital sinus relationship: part_of UBERON:0003975 {source="FMA"} ! internal female genitalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1b/Illu_repdt_female.jpg xsd:anyURI @@ -209457,15 +311826,13 @@ def: "External genital organs of the female mammal[WP]." [Wikipedia:Vulva] subset: efo_slim subset: pheno_slim subset: uberon_slim -synonym: "female pudendum" EXACT [BTO:0003101, FMA:20462] +synonym: "female pudendum" EXACT DEPRECATED [BTO:0003101, doi:10.1002/ca.23705, FMA:20462] synonym: "mammalian vulva" EXACT [] synonym: "puboperineal region" EXACT [FMA:20462] -synonym: "pudendum" RELATED [BTO:0003101] -synonym: "pudendum femininum" EXACT LATIN [FMA:20462, FMA:TA] -synonym: "pudendum femininum" RELATED LATIN [Wikipedia:Vulva] -synonym: "pudendum muliebre" RELATED [BTO:0003101] -synonym: "skin of female pudendum" EXACT [] -synonym: "skin of vulva" EXACT [] +synonym: "pudendum" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705] +synonym: "pudendum femininum" EXACT DEPRECATED [doi:10.1002/ca.23705, FMA:20462, FMA:TA] +synonym: "pudendum femininum" RELATED DEPRECATED [doi:10.1002/ca.23705, Wikipedia:Vulva] +synonym: "pudendum muliebre" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705] synonym: "vulva" EXACT [MA:0000395] xref: BTO:0003101 xref: CALOHA:TS-1168 @@ -209487,6 +311854,7 @@ xref: VHOG:0001458 xref: Wikipedia:Vulva is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0005056 ! external female genitalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg xsd:anyURI property_value: UBPROP:0000001 "The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001458", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vulva"} @@ -209534,13 +311902,30 @@ xref: VHOG:0001379 xref: Wikipedia:Seminal_vesicle is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006868 ! seminal fluid secreting gland +relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia relationship: develops_from UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000473 ! testis +relationship: produces UBERON:0010143 ! seminal vesicle fluid property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg xsd:anyURI property_value: UBPROP:0000001 "Either of a pair of pouchlike glands situated on each side of the male urinary bladder that secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/prominence"} property_value: UBPROP:0000003 "(In mammalian testis) Along the way (the sperm travel), three accessory sex glands, the seminal vesicle, prostate, and bulbourethral (Cowper's) gland, respectively, add their secretions as sperm move from the testes to the urethra.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.556", source="http://bgee.unil.ch/"} property_value: UBPROP:0000009 "The seminal vesicles secrete a significant proportion of the fluid that ultimately becomes semen. Lipofuscin granules from dead epithelial cells give the secretion its yellowish color. About 50-70% of the seminal fluid in humans originates from the seminal vesicles, but is not expelled in the first ejaculate fractions which are dominated by spermatozoa and zinc-rich prostatic fluid." xsd:string +[Term] +id: UBERON:0000999 +name: ejaculatory duct +is_a: UBERON:0000025 ! tube +is_a: UBERON:0005904 ! duct of male reproductive system +is_a: UBERON:0015212 ! lateral structure +relationship: capable_of_part_of GO:0042713 ! sperm ejaculation +relationship: channel_for UBERON:0001968 ! semen +relationship: channel_for UBERON:0010143 ! seminal vesicle fluid +relationship: channels_from UBERON:0000998 ! seminal vesicle +relationship: channels_from UBERON:0001000 ! vas deferens +relationship: channels_into UBERON:0000057 ! urethra +relationship: in_lateral_side_of UBERON:0000079 ! male reproductive system +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata + [Term] id: UBERON:0001000 name: vas deferens @@ -209574,6 +311959,11 @@ xref: VHOG:0001135 xref: Wikipedia:Vas_deferens is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system +relationship: channel_for UBERON:0001968 ! semen +relationship: channels_from UBERON:0001301 ! epididymis +relationship: channels_into UBERON:0000999 ! ejaculatory duct +relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia +relationship: only_in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0005352 {source="FMA"} ! spermatic cord relationship: part_of UBERON:0006947 ! male genital duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg xsd:anyURI @@ -209586,6 +311976,7 @@ name: skin epidermis namespace: uberon def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -209622,6 +312013,7 @@ intersection_of: part_of UBERON:0002097 ! skin of body relationship: adjacent_to UBERON:0002067 ! dermis relationship: developmentally_replaces UBERON:0003055 ! periderm relationship: part_of UBERON:0002097 ! skin of body +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000105", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship loss: subclass external integument structures (AAO:0000961)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO"} @@ -209638,6 +312030,7 @@ def: "Functional system which consists of structures involved in respiration." [ def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system] subset: efo_slim subset: functional_classification +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -209645,8 +312038,8 @@ synonym: "apparatus respiratorius" EXACT [] synonym: "apparatus respiratorius" RELATED [BTO:0000203] synonym: "Atmungssystem" RELATED [BTO:0000203] synonym: "respiratory system" EXACT [] -synonym: "systema respiratorium" RELATED LATIN [Wikipedia:Respiratory_system] synonym: "systema respiratorium" RELATED LATIN [http://en.wikipedia.org/wiki/Respiratory_system] +synonym: "systema respiratorium" RELATED LATIN [Wikipedia:Respiratory_system] xref: AAO:0000541 xref: BTO:0000203 xref: CALOHA:TS-1319 @@ -209683,10 +312076,12 @@ disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0003016 ! respiratory system process relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system @@ -209694,6 +312089,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: only_in_taxon NCBITaxon:33213 ! Bilateria property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000541", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000202", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000202", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23"} @@ -209763,10 +312159,12 @@ disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0022600 ! digestive system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage @@ -209824,15 +312222,23 @@ xref: Wikipedia:Excretory_system xref: XAO:0000143 xref: ZFA:0000163 is_a: UBERON:0000467 ! anatomical system +intersection_of: UBERON:0000467 ! anatomical system +intersection_of: capable_of GO:0007588 ! excretion disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system +disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system +disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system +relationship: capable_of GO:0007588 ! excretion relationship: existence_ends_during UBERON:0000066 ! fully formed stage +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa property_value: editor_note "In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here" xsd:string property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"} property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"} @@ -209864,10 +312270,12 @@ disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0003013 ! circulatory system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage @@ -209899,6 +312307,8 @@ xref: SCTID:302520004 xref: Wikipedia:Body_of_ulna is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0001424 ! ulna relationship: part_of UBERON:0001424 ! ulna [Term] @@ -209926,6 +312336,7 @@ namespace: uberon def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue" [http://en.wikipedia.org/wiki/Adipose_tissue, http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003] def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -209968,6 +312379,7 @@ intersection_of: UBERON:0002384 ! connective tissue intersection_of: composed_primarily_of CL:0000136 ! fat cell disjoint_from: UBERON:0003714 ! neural tissue relationship: composed_primarily_of CL:0000136 ! fat cell +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Connective tissue in which fat is stored.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002134", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO"} @@ -210013,7 +312425,6 @@ xref: VSAO:0005038 xref: WBbt:0005737 xref: Wikipedia:Muscular_system xref: ZFA:0000548 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 ! organ system subdivision relationship: composed_primarily_of UBERON:0001630 ! muscle organ @@ -210060,6 +312471,7 @@ xref: MESH:D009420 xref: MIAA:0000026 xref: NCIT:C12755 xref: Nervous:system +xref: neuronames:3236 xref: OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA xref: SCTID:278196006 xref: TAO:0000396 @@ -210074,10 +312486,12 @@ is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001033 ! gustatory system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0050877 ! nervous system process relationship: composed_primarily_of CL:0002319 ! neural cell @@ -210133,6 +312547,7 @@ xref: MA:0000167 xref: MAT:0000457 xref: MESH:D002490 xref: NCIT:C12438 +xref: neuronames:854 xref: OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA xref: SCTID:278199004 xref: TAO:0000012 @@ -210214,7 +312629,6 @@ synonym: "commissure" BROAD [] synonym: "commissure of neuraxis" EXACT [FMA:83906] synonym: "neuraxis commissure" EXACT [FMA:83906] synonym: "white matter commissure" NARROW [CUMBO:CUMBO] -xref: FBbt:00005103 xref: FMA:83906 xref: NCIT:C32349 xref: NLX:110 @@ -210224,6 +312638,7 @@ xref: TADS:0000201 xref: UMLS:C1185742 {source="ncithesaurus:Commissure"} xref: Wikipedia:Commissure is_a: UBERON:0001018 ! axon tract +relationship: BSPO:0005001 UBERON:0001016 ! nervous system property_value: UBPROP:0000001 "White matter fiber bundle that crosses the midline of the brain or spinal cord, that connects similar structures on both sides. (CUMBO; Heimer, L. The Human Brain, 2nd ed., 1995, pg 6)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"} property_value: UBPROP:0000007 "commissural" xsd:string @@ -210232,6 +312647,7 @@ id: UBERON:0001021 name: nerve namespace: uberon def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -210280,6 +312696,7 @@ is_a: UBERON:0000122 {source="FBbt"} ! neuron projection bundle relationship: has_developmental_contribution_from UBERON:0002342 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neural crest relationship: has_quality PATO:0002045 ! dendritic relationship: part_of UBERON:0000010 ! peripheral nervous system +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A portion of tissue which is a fasiculated group of axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007009", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000007 "nervous" xsd:string @@ -210319,6 +312736,8 @@ xref: SCTID:302518002 xref: Wikipedia:Body_of_radius is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0001423 ! radius bone relationship: part_of UBERON:0001423 ! radius bone property_value: UBPROP:0000001 "The body of the radius (or shaft of radius) is prismoid in form, narrower above than below, and slightly curved, so as to be convex lateralward. It presents three borders and three surfaces[Wikipedia:Body_of_radius]." xsd:string {source="Wikipedia:Body_of_radius"} @@ -210384,10 +312803,10 @@ xref: AAO:0010577 xref: BILA:0000143 xref: EFO:0000830 xref: FMA:7194 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2889 xref: MA:0002446 xref: MAT:0000275 xref: MIAA:0000275 +xref: neuronames:2889 xref: NLXANAT:090803 xref: SCTID:423940004 xref: TAO:0001101 @@ -210399,10 +312818,12 @@ intersection_of: UBERON:0000467 ! anatomical system intersection_of: capable_of_part_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of_part_of GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: existence_ends_during UBERON:0000066 ! fully formed stage @@ -210450,6 +312871,8 @@ is_a: UBERON:0000021 {source="FMA"} ! cutaneous appendage is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0002073 ! hair follicle +relationship: has_part GO:0045095 ! keratin filament +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0001003 {source="FMA"} ! skin epidermis relationship: part_of UBERON:0011932 {source="FMA"} ! pilosebaceous unit property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/25/Gray945.png xsd:anyURI @@ -210474,7 +312897,7 @@ xref: EHDAA:164 xref: EMAPA:16085 xref: FMA:87180 xref: GAID:1301 -xref: MESH:A16.254.403.981 +xref: MESH:D015017 xref: NCIT:C14128 xref: SCTID:362845002 xref: UMLS:C0043425 {source="ncithesaurus:Yolk_Sac"} @@ -210483,6 +312906,8 @@ xref: Wikipedia:Yolk_sac is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005631 {seeAlso="https://github.com/obophenotype/uberon/issues/635"} ! extraembryonic membrane is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac +relationship: has_developmental_contribution_from UBERON:0000925 {source="ISBN:0073040584"} ! endoderm +relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png xsd:anyURI property_value: editor_note "consider splitting class" xsd:string property_value: UBPROP:0000001 "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/yolk+sac"} @@ -210555,6 +312980,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0031354 xref: http://www.snomedbrowser.com/Codes/Details/181211006 xref: MA:0000432 xref: MESH:A03.867 +xref: MESH:D010614 xref: NCIT:C12425 xref: OpenCyc:Mx4rvViv7ZwpEbGdrcN5Y29ycA xref: SCTID:181211006 @@ -210610,7 +313036,7 @@ xref: GAID:291 xref: galen:Esophagus xref: MA:0000352 xref: MAT:0000048 -xref: MESH:A03.365 +xref: MESH:D004947 xref: MIAA:0000048 xref: NCIT:C12389 xref: OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA @@ -210668,6 +313094,13 @@ xref: UMLS:C0036098 {source="ncithesaurus:Salivary_Gland"} xref: VHOG:0000376 xref: Wikipedia:Salivary_gland is_a: UBERON:0010047 ! oral gland +intersection_of: UBERON:0002530 ! gland +intersection_of: produces UBERON:0001836 ! saliva +relationship: capable_of GO:0046541 ! saliva secretion +relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system +relationship: located_in UBERON:0000167 ! oral cavity +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria +relationship: produces UBERON:0001836 ! saliva property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg xsd:anyURI property_value: IAO:0000232 "currently we define saliva and salivary glands very generally in functional terms but it may be more appropriate to split this class. From WP: In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals." xsd:string {source="3"} property_value: UBPROP:0000001 "A gland that produces the saliva. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000376", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -210757,7 +313190,6 @@ property_value: UBPROP:0000012 "in FMA this class has no children. In MA it has id: UBERON:0001047 name: neural glomerulus namespace: uberon -alt_id: UBERON:FBbt_00005386 def: "Large synaptic bouton found in areas like olfactory bulb, cerebellar cortex and thalamus, that contacts many post-synaptic targets[NIF]." [http://ccdb.ucsd.edu/SAO/images/glomerulus_sw_512x512.jpg, http://flybrain.uni-freiburg.de/Flybrain/html/terms/terms.html] comment: isa or partof neuropil? TODO. Add to GO-CC? subset: uberon_slim @@ -210823,9 +313255,11 @@ xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1365 xref: http://linkedlifedata.com/resource/umls/id/C0231024 xref: http://www.snomedbrowser.com/Codes/Details/362852000 xref: MAT:0000069 +xref: MESH:D054259 xref: MIAA:0000069 xref: NCIT:C34226 xref: Neural:tube +xref: neuronames:1365 xref: SCTID:362852000 xref: TAO:0001135 xref: UMLS:C0231024 {source="ncithesaurus:Neural_Tube"} @@ -210866,7 +313300,7 @@ xref: EV:0100068 xref: FMA:54880 xref: GAID:338 xref: MA:0001796 -xref: MESH:A03.867.490 +xref: MESH:D007013 xref: NCIT:C12246 xref: OpenCyc:Mx4rvq5O0JwpEbGdrcN5Y29ycA xref: SCTID:281490009 @@ -210875,8 +313309,10 @@ xref: VHOG:0000445 xref: Wikipedia:Hypopharynx is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0013522 ! subdivision of tube +relationship: continuous_with UBERON:0013472 ! upper esophagus +relationship: contributes_to_morphology_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx -property_value: depicted:by Illu:pharynx.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg xsd:anyURI property_value: UBPROP:0000001 "The inferior portion of the pharynx, between the epiglottis and the larynx. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000445", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/hypopharynx"} property_value: UBPROP:0000007 "hypopharyngeal" xsd:string @@ -210887,6 +313323,7 @@ namespace: uberon def: "the terminal portion of the intestinal tube, terminating with the anus" [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "intestinum rectum" RELATED [BTO:0001158] @@ -210910,6 +313347,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/181261002 xref: MA:0000336 xref: MAT:0000050 xref: MESH:A03.492.411.495.767 +xref: MESH:D012007 xref: MIAA:0000050 xref: NCIT:C12390 xref: OpenCyc:Mx4rvVjaU5wpEbGdrcN5Y29ycA @@ -210926,6 +313364,7 @@ relationship: part_of UBERON:0000059 {source="MA"} ! large intestine relationship: part_of UBERON:0006866 ! terminal part of digestive tract relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001751", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001751", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "rectal" xsd:string @@ -210981,12 +313420,12 @@ xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance xref: WBbt:0000100 xref: XAO:0000000 xref: ZFA:0100000 +is_a: BFO:0000004 ! independent continuant [Term] id: UBERON:0001063 name: flocculus namespace: uberon -alt_id: UBERON:Flocculus-MA_0000992 def: "The small lobe of the cerebellum at the posterior border of the middle cerebellar peduncle anterior to the biventer lobule that receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance." [http://orcid.org/0000-0002-6601-2165, ISBN:0838580343, MGI:csmith, MP:0010006, Wikipedia:Flocculus_(cerebellar)] subset: pheno_slim subset: uberon_slim @@ -211004,9 +313443,9 @@ xref: DMBA:16946 xref: EMAPA:35346 xref: FMA:83881 xref: HBA:12945 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=680 xref: MA:0000992 xref: MBA:1049 +xref: neuronames:680 xref: SCTID:279368002 xref: SCTID:30711003 xref: Wikipedia:Flocculus_(cerebellar) @@ -211020,6 +313459,47 @@ property_value: UBPROP:0000008 "enlarged in pterosaurs" xsd:string {source="PMID property_value: UBPROP:0000009 "At its base, the flocculus receives input from the middle ears vestibular system and regulates balance. Many floccular projections descend to the spinal cord and connect to the motor nuclei involved in control of eye movement." xsd:string {source="WP"} property_value: UBPROP:0000012 "flocculus is an exact label for two distinct classes in NIF." xsd:string {external_ontology="NIF"} +[Term] +id: UBERON:0001064 +name: ventral pancreatic duct +namespace: uberon +alt_id: UBERON:0005627 +def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct] +subset: human_reference_atlas +subset: uberon_slim +synonym: "canal of Wirsung" RELATED [BTO:0002362] +synonym: "chief pancreatic duct" EXACT [FMA:16003] +synonym: "duct of Wirsung" EXACT [Wikipedia:Pancreatic_duct] +synonym: "ductus pancreatis ventralis" RELATED [] +synonym: "hepaticopancreatic duct" RELATED [BTO:0002362] +synonym: "main pancreatic duct" EXACT [MA:0000126] +synonym: "pancreatic duct" BROAD [MESH:A03.734.667] +xref: BTO:0002362 +xref: EHDAA2:0001396 +xref: EHDAA:6905 +xref: EMAPA:17510 +xref: FMA:16003 +xref: GAID:337 +xref: MA:0000126 +xref: MESH:D010183 +xref: NCIT:C12272 +xref: RETIRED_EHDAA2:0002177 +xref: SCTID:245385001 +xref: UMLS:C0030288 {source="ncithesaurus:Pancreatic_Duct"} +xref: VHOG:0000256 +xref: Wikipedia:Pancreatic_duct +is_a: UBERON:0000025 ! tube +is_a: UBERON:0007329 {source="FMA"} ! pancreatic duct +relationship: channel_for UBERON:0001970 ! bile +relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla +relationship: continuous_with UBERON:0001174 ! common bile duct +relationship: develops_from UBERON:0003924 {source="EHDAA2"} ! ventral pancreatic bud +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png xsd:anyURI +property_value: editor_note "in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue" xsd:string +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000256", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"} +property_value: UBPROP:0000011 "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." xsd:string {source="WP"} + [Term] id: UBERON:0001065 name: parotid main excretory duct @@ -211073,13 +313553,16 @@ xref: EMAPA:32739 xref: FMA:10446 xref: GAID:105 xref: MA:0000110 -xref: MESH:A02.165.410 +xref: MESH:D007403 xref: NCIT:C49571 xref: OpenCyc:Mx4rv11AcpwpEbGdrcN5Y29ycA xref: SCTID:244570000 xref: UMLS:C0021815 {source="ncithesaurus:Intervertebral_Disc"} xref: Wikipedia:Intervertebral_disk is_a: UBERON:0011135 ! intervertebral cartilage +intersection_of: UBERON:0011135 ! intervertebral cartilage +intersection_of: has_part UBERON:0002242 ! nucleus pulposus +relationship: has_part UBERON:0002242 ! nucleus pulposus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/92/Gray301.png xsd:anyURI property_value: UBPROP:0000008 "strictly speaking the term intervertebral disk [applies to intervertebral cartilage]" xsd:string @@ -211139,6 +313622,7 @@ name: external carotid artery namespace: uberon def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -211167,6 +313651,7 @@ relationship: branching_part_of UBERON:0001530 {source="FMA"} ! common carotid a relationship: develops_from UBERON:0001530 {source="EHDAA2"} ! common carotid artery plus branches relationship: part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722 xsd:anyURI property_value: UBPROP:0000008 "not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO" xsd:string @@ -211177,6 +313662,7 @@ namespace: uberon def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [http://en.wikipedia.org/wiki/Superficial_part_of_transverse_cervical_artery] def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery] comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] +subset: human_reference_atlas subset: uberon_slim synonym: "superficial branch of transverse cervical artery" EXACT [http://en.wikipedia.org/wiki/Superficial_part_of_transverse_cervical_artery] synonym: "superficial branch of transverse cervical artery" EXACT [Wikipedia:Superficial_part_of_transverse_cervical_artery] @@ -211193,7 +313679,9 @@ xref: Wikipedia:Superficial_part_of_transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: part_of UBERON:0035549 ! vasculature of integument +relationship: connected_to UBERON:0012324 ! transverse cervical artery relationship: part_of UBERON:0035549 ! vasculature of integument +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001072 @@ -211201,6 +313689,7 @@ name: posterior vena cava namespace: uberon def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava] def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://en.wikipedia.org/wiki/Inferior_vena_cava, http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "caudal vena cava" RELATED [VHOG:0001194] @@ -211235,12 +313724,34 @@ is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: drains UBERON:0000154 ! posterior region of body disjoint_from: UBERON:0001585 {source="lexical"} ! anterior vena cava +relationship: channels_into UBERON:0002078 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! right cardiac atrium +relationship: connected_to UBERON:0002078 ! right cardiac atrium +relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein relationship: drains UBERON:0000154 ! posterior region of body property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." xsd:string {source="FMA:10951"} property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001194", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455"} property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001194", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001073 +name: ileocecal junction +namespace: uberon +def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539] +synonym: "ileocaecal junction" EXACT [] +xref: EMAPA:37601 {source="MA:th"} +xref: FMA:11338 +xref: MA:0000332 +xref: SCTID:264021000 +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0000059 ! large intestine +intersection_of: connects UBERON:0002108 ! small intestine +relationship: connects UBERON:0000059 ! large intestine +relationship: connects UBERON:0002108 ! small intestine +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata + [Term] id: UBERON:0001074 name: pericardial cavity @@ -211321,6 +313832,8 @@ xref: Wikipedia:Body_of_vertebra xref: ZFA:0000126 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0016491 ! vertebral centrum element +intersection_of: UBERON:0016491 ! vertebral centrum element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: part_of UBERON:0002412 ! vertebra property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/63/Corpusvertebrae.png xsd:anyURI property_value: UBPROP:0000001 "Centra are represented by mineralized, calcified, or ossified portions that surround the notochord. The autocentrum, present in Danio and all other living teleosts, is formed by direct ossification outside the elastica externa of the notochord (Arratia, 1999).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000126", ontology="TAO", source="ZFIN:curator"} @@ -211617,13 +314130,22 @@ xref: NCIT:C13283 xref: OpenCyc:Mx4rvVjGppwpEbGdrcN5Y29ycA xref: UMLS:C0042036 {source="ncithesaurus:Urine"} xref: Wikipedia:Urine -is_a: BFO:0000040 ! material entity is_a: UBERON:0000174 ! excreta intersection_of: UBERON:0000174 ! excreta intersection_of: produced_by UBERON:0002113 ! kidney +relationship: has_quality PATO:0001548 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! quality of a liquid relationship: produced_by UBERON:0002113 ! kidney property_value: UBPROP:0000008 "kidney excreta from some taxa (e.g. in aves) may not be liquid" xsd:string +[Term] +id: UBERON:0001089 +name: sweat +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0001820 ! sweat gland +relationship: produced_by UBERON:0001820 ! sweat gland + [Term] id: UBERON:0001090 name: synovial fluid @@ -211682,7 +314204,7 @@ xref: FMA:12516 xref: GAID:1260 xref: MA:0000348 xref: MAT:0000041 -xref: MESH:A14.254.860 +xref: MESH:D014070 xref: MIAA:0000041 xref: NCIT:C12506 xref: OpenCyc:Mx4rvVjUEZwpEbGdrcN5Y29ycA @@ -211696,7 +314218,11 @@ xref: ZFA:0000694 is_a: UBERON:0003913 ! tooth-like structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: has_developmental_contribution_from UBERON:0000930 ! stomodeum +relationship: has_developmental_contribution_from UBERON:0005176 ! tooth enamel organ +relationship: has_part UBERON:0001751 ! dentine relationship: immediate_transformation_of UBERON:0008281 {source="cjm"} ! tooth bud +relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg xsd:anyURI property_value: editor_note "we place ZFA ctb 5 tooth here for now. Consider changing name from calcaeeous tooth. Note that sea cucumbers develop calcareous tooth-like structures" xsd:string property_value: RO:0002161 NCBITaxon:189497 {source="Wikipedia"} @@ -211731,7 +314257,7 @@ xref: EMAPA:19431 xref: FMA:12519 xref: GAID:236 xref: MA:0001421 -xref: MESH:A02.835.232.834.151.213 +xref: MESH:D001270 xref: NCIT:C32239 xref: SCTID:181818007 xref: TAO:0001167 @@ -211792,9 +314318,9 @@ xref: AAO:0000552 xref: EMAPA:18336 xref: FMA:12526 xref: galen:SacralVertebra -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1706 xref: MA:0000313 xref: NCIT:C12853 +xref: neuronames:1706 xref: OpenCyc:Mx4rv-ZsXpwpEbGdrcN5Y29ycA xref: SCTID:361773005 xref: UMLS:C1261045 {source="ncithesaurus:Sacral_Vertebra"} @@ -211804,6 +314330,8 @@ is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015010 ! sacral vertebra endochondral element +intersection_of: UBERON:0015010 ! sacral vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010745 ! sacral vertebra cartilage element property_value: editor_note "todo - AAO placement to be confirmed by AAO curators (the AAO class may also include modified ribs)" xsd:string property_value: UBPROP:0000001 "Enlarged vertebra with transverse processes (diapophyses), and ocassionally ribs, that are modified and elaborated for support of the pelvic girdle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000552", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} @@ -211843,6 +314371,8 @@ xref: ZFA:0000326 is_a: UBERON:0002412 ! vertebra is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue property_value: UBPROP:0000001 "Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000326", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000012 "we deliberately merge the MA classes as we believe them equivalent" xsd:string {external_ontology="MA"} @@ -211906,7 +314436,7 @@ xref: EMAPA:32889 xref: FMA:12823 xref: GAID:1263 xref: MA:0000349 -xref: MESH:A14.254.860.425 +xref: MESH:D007180 xref: NCIT:C32769 xref: OpenCyc:Mx4rwP1ch5wpEbGdrcN5Y29ycA xref: SCTID:420856006 @@ -211939,7 +314469,15 @@ xref: UMLS:C0224347 {source="ncithesaurus:Pectoralis_Minor"} xref: VHOG:0000902 xref: Wikipedia:Pectoralis_minor_muscle is_a: UBERON:0001495 {source="FMA"} ! pectoral muscle -property_value: depicted:by Pectoralis:minor.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png xsd:anyURI + +[Term] +id: UBERON:0001102 +name: cartilage of main bronchus +is_a: UBERON:0001956 ! cartilage of bronchus +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus [Term] id: UBERON:0001103 @@ -211972,6 +314510,7 @@ xref: SCTID:181614006 xref: UMLS:C0011980 {source="ncithesaurus:Diaphragm"} xref: VHOG:0000713 xref: Wikipedia:Thoracid_diaphragm +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: immediate_transformation_of UBERON:0010084 {evidence="definitional"} ! future diaphragm @@ -212014,11 +314553,15 @@ xref: VHOG:0000849 xref: VSAO:0005031 xref: Wikipedia:Clavicle is_a: UBERON:0002495 {source="FMA"} ! long bone +is_a: UBERON:0003461 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! shoulder bone is_a: UBERON:0007829 ! pectoral girdle bone is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure relationship: develops_from UBERON:0010905 {editor="mah", source="ISBN:978-0-12-319060-4"} ! clavicle bone primordium -property_value: depicted:by Pectoral:girdles-en.svg xsd:anyURI +relationship: has_developmental_contribution_from UBERON:0010843 ! clavicle cartilage element +relationship: in_lateral_side_of UBERON:0002091 ! appendicular skeleton +relationship: overlaps UBERON:0001469 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! sternoclavicular joint +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg xsd:anyURI property_value: UBPROP:0000001 "Slender, paired bones of intramembranous origin that invest the anterior margins of the procoracoids.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000761", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: part_of zonal element (AAO:0000936)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000761", ontology="AAO"} property_value: UBPROP:0000003 "In early tetrapods, the connecting skull bone, the posttemporal, and adjoining shoulder bones, supracleithrum and postcleithrum (=anocleithrum), are absent, leaving a dermal shoulder girdle composed of the remaining ventral elements: the paired cleithrum and clavicle, and an unpaired midventral interclavicle that joins both halves of the girdle across the midline. (...) Several dermal elements of the shoulder persist in early synapsids. The clavicle and interclavicle are present in therapsids and monotremes, but in marsupials and placentals, the interclavicle is absent, the clavicle often is reduced in size, and the scapula becomes the predominant shoulder element.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000849", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.330-333 and Figure 9.18", source="http://bgee.unil.ch/"} @@ -212090,10 +314633,120 @@ is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034908 ! scapular muscle relationship: develops_from UBERON:0010982 {source="EHDAA2"} ! latissimus dorsi pre-muscle mass +relationship: has_muscle_antagonist UBERON:0001476 ! deltoid +relationship: has_muscle_antagonist UBERON:0002380 ! trapezius muscle +relationship: has_muscle_insertion UBERON:0000976 ! humerus +relationship: has_muscle_origin UBERON:0006849 ! scapula +relationship: has_muscle_origin UBERON:0007175 ! inferior angle of scapula relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle -property_value: depicted:by Latissimus:dorsi.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png xsd:anyURI property_value: UBPROP:0000008 "In humans it inserts along a roughened line deep in the groove. In other mammals (most, I believe) it is an actual projection, the latissimus dorsi process [FEED:rd] [https://github.com/obophenotype/uberon/issues/1192]" xsd:string +[Term] +id: UBERON:0001113 +name: lobe of liver +namespace: uberon +def: "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." [Wikipedia:Liver#Lobes] +synonym: "hepatic lobe" EXACT [] +synonym: "liver lobe" EXACT [] +synonym: "lobus hepatis" EXACT [] +xref: EMAPA:18306 +xref: FMA:13361 +xref: MA:0000360 +xref: NCIT:C49579 +xref: SCTID:245378000 +xref: UMLS:C0447541 {source="ncithesaurus:Liver_Lobe"} +xref: Wikipedia:Liver#Lobes +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe +relationship: part_of UBERON:0002107 ! liver +property_value: editor_note "some work needs to be done to ensure the child terms of this class have correct isa/partof placement. in MA they are subclasses, in FMA they are parts" xsd:string + +[Term] +id: UBERON:0001114 +name: right lobe of liver +namespace: uberon +def: "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." [Wikipedia:Right_lobe_of_liver] +subset: uberon_slim +subset: vertebrate_core +synonym: "2nd lobe" RELATED [TAO:0005173] +synonym: "gall bladder lobe" RELATED SENSU [ZFA:0005173] +synonym: "liver right lobe" EXACT [] +synonym: "lobus hepaticus dexter" EXACT LATIN [] +synonym: "lobus hepatis dexter" RELATED LATIN [Wikipedia:Right_lobe_of_liver] +synonym: "right hepatic lobe" RELATED [EMAPA:18311] +synonym: "right liver lobe" EXACT [ZFA:0005173] +synonym: "second lobe" RELATED [TAO:0005173] +xref: EHDAA2:0001008 +xref: EHDAA:4001 +xref: EMAPA:18311 +xref: FMA:13362 +xref: MA:0000363 +xref: NCIT:C33481 +xref: SCTID:362182008 +xref: TAO:0005173 +xref: UMLS:C0227481 {source="ncithesaurus:Right_Lobe_of_the_Liver"} +xref: VHOG:0001424 +xref: Wikipedia:Right_lobe_of_liver +xref: ZFA:0005173 +is_a: UBERON:0001113 ! lobe of liver +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png xsd:anyURI +property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005173", ontology="TAO", source="ZFIN:curator"} + +[Term] +id: UBERON:0001115 +name: left lobe of liver +namespace: uberon +def: "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." [Wikipedia:Left_lobe_of_liver] +subset: uberon_slim +subset: vertebrate_core +synonym: "left hepatic lobe" RELATED [EMAPA:18307] +synonym: "left liver lobe" EXACT [] +synonym: "liver left lobe" EXACT [] +synonym: "lobus hepaticus sinister" EXACT LATIN [] +synonym: "lobus hepatis sinister" RELATED LATIN [Wikipedia:Left_lobe_of_liver] +xref: EHDAA2:0001000 +xref: EHDAA:3995 +xref: EMAPA:18307 +xref: FMA:13363 +xref: MA:0000361 +xref: NCIT:C32965 +xref: SCTID:362183003 +xref: TAO:0005172 +xref: UMLS:C0227486 {source="ncithesaurus:Left_Lobe_of_the_Liver"} +xref: VHOG:0001423 +xref: Wikipedia:Left_lobe_of_liver +xref: ZFA:0005172 +is_a: UBERON:0001113 ! lobe of liver +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png xsd:anyURI +property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's left side.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005172", ontology="TAO", source="ZFIN:curator"} + +[Term] +id: UBERON:0001118 +name: lobe of thyroid gland +is_a: UBERON:0009912 ! anatomical lobe +is_a: UBERON:0015212 ! lateral structure +is_a: UBERON:0035075 ! thymus subunit +intersection_of: UBERON:0009912 ! anatomical lobe +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: in_lateral_side_of UBERON:0002046 ! thyroid gland + +[Term] +id: UBERON:0001119 +name: right lobe of thyroid gland +is_a: UBERON:0001118 ! lobe of thyroid gland +intersection_of: UBERON:0001118 ! lobe of thyroid gland +intersection_of: in_right_side_of UBERON:0002046 ! thyroid gland +relationship: in_right_side_of UBERON:0002046 ! thyroid gland + +[Term] +id: UBERON:0001120 +name: left lobe of thyroid gland +is_a: UBERON:0001118 ! lobe of thyroid gland +intersection_of: UBERON:0001118 ! lobe of thyroid gland +intersection_of: in_left_side_of UBERON:0002046 ! thyroid gland +relationship: in_left_side_of UBERON:0002046 ! thyroid gland + [Term] id: UBERON:0001125 name: serratus ventralis @@ -212121,7 +314774,11 @@ xref: Wikipedia:Serratus_anterior_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0034908 ! scapular muscle relationship: develops_from UBERON:0010986 {source="EHDAA2"} ! serratus ventralis pre-muscle mass -property_value: depicted:by Serratus:anterior.png xsd:anyURI +relationship: has_muscle_antagonist UBERON:0002380 ! trapezius muscle +relationship: has_muscle_insertion UBERON:0006849 ! scapula +relationship: has_muscle_origin UBERON:0002228 ! rib +relationship: innervated_by UBERON:0003726 ! thoracic nerve +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png xsd:anyURI [Term] id: UBERON:0001130 @@ -212167,13 +314824,31 @@ xref: XAO:0003074 xref: ZFA:0001559 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: composed_primarily_of UBERON:0010913 ! vertebral element +relationship: composed_primarily_of UBERON:0010913 ! vertebral element +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0011138 {source="cjm"} ! postcranial axial skeletal system +relationship: protects UBERON:0002240 ! spinal cord property_value: editor_note "Note that in contrast to VSAO, this is a subset of the skeletal system, and thus includes intervertebral joints, cartilage and ligaments etc. Some ontologies such as AAO seem to purely refer to the skeleton" xsd:string property_value: RO:0002161 NCBITaxon:7762 property_value: UBPROP:0000001 "Anatomical cluster that consists of all the vertebra in the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000185", ontology="VSAO", source="VSAO:curator"} property_value: UBPROP:0000001 "The vertebral column consists of a series of vertebrae connected by ligaments. It provides a supporting axis for the body and protects the spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001142", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vertebral+column"} property_value: UBPROP:0000003 "Vertebrata is characterized by three synapomorphies. First, vertebrates have a backbone composed of vertebrae (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001142", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.53", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001131 +name: vertebral foramen +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0004111 ! anatomical conduit +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: conduit_for UBERON:0002240 ! spinal cord +intersection_of: lumen_of UBERON:0010913 ! vertebral element +relationship: conduit_for UBERON:0002240 ! spinal cord +relationship: lumen_of UBERON:0010913 ! vertebral element +relationship: part_of UBERON:0006692 ! vertebral canal +relationship: part_of UBERON:0010913 ! vertebral element + [Term] id: UBERON:0001132 name: parathyroid gland @@ -212204,6 +314879,9 @@ xref: VHOG:0001188 xref: Wikipedia:Parathyroid_gland xref: XAO:0000167 is_a: UBERON:0002368 ! endocrine gland +relationship: capable_of GO:0035898 ! parathyroid hormone secretion +relationship: capable_of_part_of GO:0055074 ! calcium ion homeostasis +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda property_value: UBPROP:0000001 "Any one of several small structures, usually four, attached to the dorsal surfaces of the lateral lobes of the thyroid gland. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001188", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/parathyroid+gland"} property_value: UBPROP:0000001 "Either of the two pairs of small, spherical, encapsulated glands which develop from ventral growths of the third and fourth pharyngeal pouches and are closely associated with the external jugular veins. Calcitonin and parathyroid hormone are secreted by these glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010545", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "The evolution of the tetrapods, and the shift from an aquatic to a terrestrial environment, was believed to have required new controls for regulating calcium homeostasis, and thus the evolution of parathyroid glands (...) both the tetrapod parathyroid and the gills of fish contribute to the regulation of extracellular calcium levels. It is therefore reasonable to suggest that the parathyroid gland evolved as a result of the transformation of the gills into the parathyroid glands of tetrapods and the transition from an aquatic to a terrestrial environment. This interpretation would also explain the positioning of the parathyroid gland within the pharynx in the tetrapod body. Were the parathyroid gland to have emerged de novo with the evolution of the tetrapods it could, as an endocrine organ, have been placed anywhere in the body and still exert its effect.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001188", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M, Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} @@ -212291,7 +314969,7 @@ intersection_of: composed_primarily_of CL:0008002 ! skeletal muscle fiber relationship: composed_primarily_of CL:0008002 ! skeletal muscle fiber relationship: develops_from UBERON:0003082 ! myotome relationship: part_of UBERON:0014892 ! skeletal muscle organ -property_value: depicted:by Skeletal:muscle.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg xsd:anyURI property_value: editor_note "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string property_value: UBPROP:0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005277", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" xsd:string {external_class="FMA:14069", ontology="FMA"} @@ -212351,6 +315029,7 @@ relationship: composed_primarily_of CL:0000192 ! smooth muscle cell relationship: has_part CL:0000192 ! smooth muscle cell relationship: has_part GO:0071953 ! elastic fiber property_value: depicted:by Glatte:Muskelzellen.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg xsd:anyURI property_value: UBPROP:0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005274", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010244", ontology="AAO", source="AAO:CAM"} property_value: UBPROP:0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001246", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)"} @@ -212414,6 +315093,7 @@ xref: galen:Back xref: http://linkedlifedata.com/resource/umls/id/C0004600 xref: http://www.snomedbrowser.com/Codes/Details/123961009 xref: MESH:A01.176 +xref: MESH:D001415 xref: NCIT:C13062 xref: OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA xref: SCTID:123961009 @@ -212425,11 +315105,43 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/4 property_value: UBPROP:0000007 "dorsal" xsd:string property_value: UBPROP:0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" xsd:string +[Term] +id: UBERON:0001138 +name: superior mesenteric vein +namespace: uberon +def: "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Superior_mesenteric_vein] +subset: human_reference_atlas +subset: uberon_slim +synonym: "upper mesenteric vein" RELATED [BTO:0002783] +synonym: "vena mesenterica superior" RELATED LATIN [Wikipedia:Superior_mesenteric_vein] +xref: BTO:0002783 +xref: EHDAA2:0001951 +xref: EHDAA:5414 +xref: EMAPA:18643 +xref: FMA:14332 +xref: MA:0002179 +xref: NCIT:C33687 +xref: OpenCyc:Mx4rwFjmM5wpEbGdrcN5Y29ycA +xref: SCTID:278031001 +xref: UMLS:C0226742 {source="ncithesaurus:Superior_Mesenteric_Vein"} +xref: VHOG:0000552 +xref: Wikipedia:Superior_mesenteric_vein +is_a: UBERON:0005617 ! mesenteric vein +intersection_of: UBERON:0005617 ! mesenteric vein +intersection_of: drains UBERON:0002108 ! small intestine +relationship: connected_to UBERON:0001639 ! hepatic portal vein +relationship: develops_from UBERON:0005487 {source="Wikipedia:Vitelline_vein"} ! vitelline vein +relationship: drains UBERON:0002108 ! small intestine +relationship: part_of UBERON:0005806 ! portal system +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0001140 name: renal vein namespace: uberon def: "Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava." [ISBN:0-683-40008-8, MGI:csmith, MP:0011323] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney vein" EXACT [OBOL:automatic] @@ -212461,6 +315173,7 @@ relationship: drains UBERON:0002113 ! kidney relationship: part_of UBERON:0001072 ! posterior vena cava relationship: tributary_of UBERON:0001072 ! posterior vena cava property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]." xsd:string {source="Renal:vein"} property_value: UBPROP:0000001 "The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]." xsd:string {source="Wikipedia:Renal_vein"} property_value: UBPROP:0000012 "in EHDAA2, the renal vein is part of the kidney" xsd:string {external_ontology="EHDAA2"} @@ -212470,6 +315183,7 @@ id: UBERON:0001141 name: right renal vein namespace: uberon def: "A renal vein that drains the right kidney." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37381 {source="MA:th"} xref: FMA:14335 @@ -212479,6 +315193,10 @@ xref: OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvdUXKJwpEbGdrcN5Y29ycA xref: SCTID:116357001 xref: UMLS:C0508000 {source="ncithesaurus:Right_Renal_Vein"} is_a: UBERON:0001140 ! renal vein +intersection_of: UBERON:0001140 ! renal vein +intersection_of: drains UBERON:0004539 ! right kidney +relationship: drains UBERON:0004539 ! right kidney +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A vein that drains blood from the right kidney into the inferior vena cava[ncithesaurus]." xsd:string {source="ncithesaurus:Right_Renal_Vein"} [Term] @@ -212486,6 +315204,7 @@ id: UBERON:0001142 name: left renal vein namespace: uberon def: "A renal vein that drains the left kidney." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37166 {source="MA:th"} xref: FMA:14336 @@ -212495,7 +315214,11 @@ xref: OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvdUXKJwpEbGdrcN5Y29ycA xref: SCTID:116356005 xref: UMLS:C0508001 {source="ncithesaurus:Left_Renal_Vein"} is_a: UBERON:0001140 ! renal vein +intersection_of: UBERON:0001140 ! renal vein +intersection_of: drains UBERON:0004538 ! left kidney +relationship: drains UBERON:0004538 ! left kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A vein that drains blood from the left kidney into the inferior vena cava[ncithesaurus]." xsd:string {source="ncithesaurus:Left_Renal_Vein"} [Term] @@ -212528,10 +315251,29 @@ xref: XAO:0000387 xref: ZFA:0000670 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002107 ! liver +disjoint_from: UBERON:0001639 ! hepatic portal vein +relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein +relationship: drains UBERON:0002107 ! liver relationship: part_of UBERON:0006877 ! vasculature of liver +relationship: tributary_of UBERON:0001072 {source="FMA-abduced-lr"} ! posterior vena cava property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png xsd:anyURI property_value: editor_note "todo - add developmental relationships for other taxa" xsd:string +[Term] +id: UBERON:0001144 +name: testicular vein +is_a: UBERON:0001638 ! vein +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0000473 ! testis +relationship: connected_to UBERON:0001072 ! posterior vena cava +relationship: connected_to UBERON:0001330 ! pampiniform plexus +relationship: drains UBERON:0000473 ! testis +relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism +relationship: sexually_homologous_to UBERON:0001145 ! ovarian vein + [Term] id: UBERON:0001145 name: ovarian vein @@ -212566,6 +315308,14 @@ relationship: drains UBERON:0000992 ! ovary relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg xsd:anyURI +[Term] +id: UBERON:0001146 +name: suprarenal vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002369 ! adrenal gland +relationship: drains UBERON:0002369 ! adrenal gland + [Term] id: UBERON:0001152 name: cystic duct @@ -212582,7 +315332,7 @@ xref: FMA:14539 xref: GAID:290 xref: galen:CysticDuct xref: MA:0000355 -xref: MESH:A03.159.183.419 +xref: MESH:D003549 xref: NCIT:C32421 xref: OpenCyc:Mx4rveBeC5wpEbGdrcN5Y29ycA xref: SCTID:245398005 @@ -212592,6 +315342,13 @@ xref: VHOG:0000213 xref: Wikipedia:Cystic_duct xref: ZFA:0005166 is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: continuous_with UBERON:0001174 ! common bile duct +intersection_of: continuous_with UBERON:0002110 ! gall bladder +disjoint_from: UBERON:0005171 ! hepatic duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: continuous_with UBERON:0001174 ! common bile duct +relationship: continuous_with UBERON:0002110 ! gall bladder relationship: develops_from UBERON:0005604 {source="EHDAA2"} ! extrahepatic part of hepatic duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI @@ -212605,6 +315362,7 @@ namespace: uberon def: "A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction." [Wikipedia:Cecum] comment: Taxon notes: in some herbivorous lizards, a cecum is present between small and large intestines[Kardong] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "blind intestine" RELATED [BTO:0000166] @@ -212627,7 +315385,7 @@ xref: FMA:14541 xref: GAID:307 xref: galen:Cecum xref: MA:0000334 -xref: MESH:A03.492.411.495.209 +xref: MESH:D002432 xref: MIAA:0000288 xref: NCIT:C12381 xref: OpenCyc:Mx4rve6u4JwpEbGdrcN5Y29ycA @@ -212636,13 +315394,26 @@ xref: UMLS:C0007531 {source="ncithesaurus:Cecum"} xref: VHOG:0001559 xref: Wikipedia:Cecum is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: continuous_with UBERON:0001156 ! ascending colon +relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of UBERON:0001155 {source="EHDAA2"} ! colon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:32443 {source="Wikipedia"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "caecal" xsd:string property_value: UBPROP:0000008 "A cecum is present in most amniote species, and also in lungfish, but not in any living species of amphibian. In reptiles, it is usually a single median structure, arising from the dorsal side of the large intestine. Birds typically have two paired ceca, as, unlike other mammals, do hyraxes. Most mammalian herbivores have a relatively large cecum, hosting a large number of bacteria, which aid in the enzymatic breakdown of plant materials such as cellulose; in many species, it is considerably wider than the colon. In contrast, obligatory carnivores, whose diets contain little or no plant material, have a reduced cecum, which is often partially or wholly replaced by the vermiform appendix. Many fish have a number of small outpocketings, called pyloric ceca, along their intestine; despite the name they are not homologous with the cecum of amniotes, and their purpose is to increase the overall area of the digestive epithelium.[2] Some invertebrates, such as squid,[3] may also have structures with the same name, but these have no relationship with those of vertebrates." xsd:string {source="WP"} +[Term] +id: UBERON:0001154 +name: vermiform appendix +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0013765 ! digestive system element +relationship: continuous_with UBERON:0001153 ! caecum +relationship: develops_from UBERON:0001045 ! midgut +relationship: part_of UBERON:0000059 ! large intestine + [Term] id: UBERON:0001155 name: colon @@ -212672,6 +315443,7 @@ xref: MA:0000335 xref: MAP:0000001 xref: MAT:0000526 xref: MESH:A03.492.411.495.356 +xref: MESH:D003106 xref: NCIT:C12382 xref: OpenCyc:Mx4rvgLEM5wpEbGdrcN5Y29ycA xref: SCTID:302508007 @@ -212683,6 +315455,7 @@ xref: XAO:0000243 xref: ZFA:0000706 is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000059 {source="FMA"} ! large intestine property_value: editor_note "Some references do not consider the caecum to be part of the colon." xsd:string {xref="http://orcid.org/0000-0002-1572-1316"} property_value: editor_note "TODO - abstract this such that it legitimately covers all vertebrates" xsd:string @@ -212695,14 +315468,38 @@ property_value: UBPROP:0000008 "In mammals, the colon consists of four sections: property_value: UBPROP:0000008 "In zebrafish, the posterior intestine has short longitudinally arranged epithelial folds which are similar to the colon of higher vertebrates[ZFIN]" xsd:string property_value: UBPROP:0000009 "it extracts water and salt from solid wastes before they are eliminated from the body[WP]" xsd:string +[Term] +id: UBERON:0001156 +name: ascending colon +is_a: UBERON:0000168 ! proximal-distal subdivision of colon +relationship: continuous_with UBERON:0001157 ! transverse colon +relationship: develops_from UBERON:0001045 ! midgut + +[Term] +id: UBERON:0001157 +name: transverse colon +is_a: UBERON:0000168 ! proximal-distal subdivision of colon +relationship: continuous_with UBERON:0001158 ! descending colon +relationship: develops_from UBERON:0001045 ! midgut + +[Term] +id: UBERON:0001158 +name: descending colon +is_a: UBERON:0000168 ! proximal-distal subdivision of colon +relationship: continuous_with UBERON:0001159 ! sigmoid colon +relationship: develops_from UBERON:0001046 ! hindgut + [Term] id: UBERON:0001159 name: sigmoid colon namespace: uberon +def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [Wikipedia:Sigmoid_colon] def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [http://en.wikipedia.org/wiki/Sigmoid_colon] subset: efo_slim +subset: human_reference_atlas subset: uberon_slim synonym: "colon sigmoideum" RELATED LATIN [http://en.wikipedia.org/wiki/Sigmoid_colon] +synonym: "colon sigmoideum" RELATED LATIN [Wikipedia:Sigmoid_colon] synonym: "pelvic colon" RELATED [] synonym: "sigmoid colon" RELATED [] synonym: "sigmoid flexure" RELATED [] @@ -212717,17 +315514,21 @@ xref: http://linkedlifedata.com/resource/umls/id/C0682612 xref: http://www.snomedbrowser.com/Codes/Details/362166007 xref: MAT:0000314 xref: MESH:A03.492.411.495.356.668 +xref: MESH:D012809 xref: MIAA:0000314 xref: NCIT:C12384 xref: NCIT:C33550 xref: OpenCyc:Mx4rwHX_-5wpEbGdrcN5Y29ycA +xref: SCTID:362166007 xref: Sigmoid:colon xref: UMLS:C0227391 {source="ncithesaurus:Sigmoid_Colon"} xref: UMLS:C0682612 {source="ncithesaurus:Sigmoid_Flexure"} +xref: Wikipedia:Sigmoid_colon is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon relationship: continuous_with UBERON:0001052 ! rectum relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001160 @@ -212753,17 +315554,46 @@ xref: FMA:14559 xref: GAID:320 xref: galen:GastricFundus xref: MA:0001612 -xref: MESH:A03.492.766.419 +xref: MESH:D005748 xref: NCIT:C12257 xref: SCTID:362139007 xref: UMLS:C0017129 {source="ncithesaurus:Fundus_of_the_Stomach"} xref: VHOG:0000421 xref: Wikipedia:Fundus_(stomach) is_a: UBERON:0009870 ! zone of stomach +relationship: contributes_to_morphology_of UBERON:0000945 ! stomach +relationship: has_part UBERON:0010038 ! fundic gastric gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI property_value: UBPROP:0000001 "The greater curvature of the stomach. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000421", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000421", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001161 +name: body of stomach +namespace: uberon +def: "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." [GO:0014845, Wikipedia:Body_of_stomach] +subset: uberon_slim +synonym: "corpus gastricum" RELATED [BTO:0000505] +synonym: "corpus gastricum" RELATED LATIN [Wikipedia:Body_of_stomach] +synonym: "corpus gastricum (ventriculare)" EXACT [] +synonym: "corpus ventriculare" RELATED [BTO:0000505] +synonym: "corpus ventriculi" RELATED [BTO:0000505] +synonym: "gastric body" EXACT [] +synonym: "gastric corpus" RELATED [] +synonym: "stomach body" EXACT [] +xref: BTO:0000505 +xref: EMAPA:35810 +xref: FMA:14560 +xref: galen:GastricCorpus +xref: MA:0002559 +xref: NCIT:C12258 +xref: SCTID:362140009 +xref: UMLS:C0227230 {source="ncithesaurus:Body_of_Stomach"} +xref: Wikipedia:Body_of_stomach +is_a: UBERON:0009870 {source="FMA"} ! zone of stomach +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI +property_value: editor_note "we include this as zone of stomach even though it is not distinguished by gland type" xsd:string + [Term] id: UBERON:0001162 name: cardia of stomach @@ -212787,16 +315617,28 @@ xref: EMAPA:35811 xref: FMA:14561 xref: GAID:319 xref: MA:0001609 -xref: MESH:A03.492.766.163 +xref: MESH:D002299 xref: NCIT:C12256 xref: SCTID:362138004 xref: UMLS:C0007144 {source="ncithesaurus:Cardia"} xref: Wikipedia:Cardia is_a: UBERON:0009870 ! zone of stomach -property_value: depicted:by Illu:stomach.jpg xsd:anyURI +intersection_of: UBERON:0009870 ! zone of stomach +intersection_of: has_part UBERON:0008859 ! cardiac gastric gland +relationship: continuous_with UBERON:0001043 ! esophagus +relationship: continuous_with UBERON:0001161 ! body of stomach +relationship: contributes_to_morphology_of UBERON:0000945 ! stomach +relationship: has_part UBERON:0008859 ! cardiac gastric gland +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg xsd:anyURI property_value: editor_note "There were previously conflicting statements in the academic anatomy community[10][11][12] over whether the cardia is part of the stomach, part of the esophagus or a distinct entity. Modern surgical and medical textbooks have agreed that 'The gastric cardia is now clearly considered to be part of the stomach'[13][14]. Classical anatomy textbooks, and some other resources[15], describe the cardia as the first of 4 regions of the stomach. This makes sense histologically because the mucosa of the cardia is the same as that of the stomach[WP]" xsd:string property_value: editor_note "We follow Kardong in defining stomach regions by glands." xsd:string +[Term] +id: UBERON:0001164 +name: greater curvature of stomach +is_a: UBERON:0009870 ! zone of stomach + [Term] id: UBERON:0001165 name: pyloric antrum @@ -212821,12 +315663,16 @@ xref: FMA:14579 xref: GAID:332 xref: galen:PyloricAntrum xref: MA:0001624 -xref: MESH:A03.492.766.716 +xref: MESH:D011706 xref: NCIT:C12259 xref: SCTID:362142001 xref: UMLS:C0034193 {source="ncithesaurus:Antrum_Pylori"} xref: Wikipedia:Pyloric_antrum is_a: UBERON:0009870 {source="FMA"} ! zone of stomach +relationship: continuous_with UBERON:0001161 ! body of stomach +relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus +relationship: has_part CL:0000502 ! type D enteroendocrine cell +relationship: has_part CL:0000508 ! type G enteroendocrine cell relationship: part_of UBERON:0001166 {source="Wikipedia"} ! pylorus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI @@ -212851,13 +315697,21 @@ xref: FMA:14581 xref: GAID:333 xref: galen:Pylorus xref: MA:0002560 -xref: MESH:A03.492.766.799 +xref: MESH:D011708 xref: NCIT:C12260 xref: SCTID:362143006 xref: UMLS:C0034196 {source="ncithesaurus:Pylorus"} xref: VHOG:0000420 xref: Wikipedia:Pylorus is_a: UBERON:0009870 ! zone of stomach +intersection_of: UBERON:0009870 ! zone of stomach +intersection_of: has_part UBERON:0001165 ! pyloric antrum +intersection_of: has_part UBERON:0008858 ! pyloric canal +intersection_of: has_part UBERON:0008861 ! pyloric gastric gland +relationship: contributes_to_morphology_of UBERON:0000945 ! stomach +relationship: has_part UBERON:0001165 ! pyloric antrum +relationship: has_part UBERON:0008858 ! pyloric canal +relationship: has_part UBERON:0008861 ! pyloric gastric gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg xsd:anyURI property_value: editor_note "We follow Kardong in defining stomach regions by glands" xsd:string property_value: UBPROP:0000001 "The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000420", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -212908,6 +315762,8 @@ xref: MA:0002696 xref: NCIT:C33573 xref: UMLS:C1519375 {source="ncithesaurus:Small_Intestinal_Wall_Tissue"} is_a: UBERON:0001262 ! wall of intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine [Term] @@ -212927,6 +315783,26 @@ intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine +[Term] +id: UBERON:0001170 +name: mesentery of small intestine +namespace: uberon +def: "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." [Wikipedia:Mesentery#Mesentery_.28proper.29] +synonym: "mesentery (proper)" EXACT [Wikipedia:Mesentery] +synonym: "mesentery proper" EXACT [FMA:14643] +synonym: "small intestinal mesentery" EXACT [FMA:14643] +synonym: "small intestine mesentery" EXACT [OBOL:automatic] +xref: EMAPA:37745 {source="MA:th"} +xref: FMA:14643 +xref: MA:0001555 +xref: SCTID:245456008 +xref: Wikipedia:Mesentery#Mesentery_.28proper.29 +is_a: UBERON:0001206 ! serosa of small intestine +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 {source="FMA"} ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0002108 ! small intestine + [Term] id: UBERON:0001171 name: portal lobule @@ -212939,6 +315815,7 @@ xref: NCIT:C33341 xref: UMLS:C0682620 {source="ncithesaurus:Portal_Lobule"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009911 {source="FMA"} ! lobule +relationship: contributes_to_morphology_of UBERON:0001280 ! liver parenchyma relationship: part_of UBERON:0001280 {source="MA", source="MP"} ! liver parenchyma [Term] @@ -212956,6 +315833,8 @@ xref: SCTID:272214009 xref: UMLS:C0227519 {source="ncithesaurus:Liver_Acinus"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011858 ! acinus of exocrine gland +relationship: overlaps UBERON:0001171 ! portal lobule +relationship: overlaps UBERON:0004647 ! liver lobule relationship: part_of UBERON:0001280 {source="cjm"} ! liver parenchyma [Term] @@ -212977,7 +315856,15 @@ xref: Wikipedia:Biliary_tract xref: XAO:0000455 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0000062 ! organ +intersection_of: composed_primarily_of UBERON:0002394 ! bile duct +intersection_of: part_of UBERON:0002294 ! biliary system +relationship: composed_primarily_of UBERON:0002394 ! bile duct +relationship: contributes_to_morphology_of UBERON:0002423 ! hepatobiliary system relationship: develops_from UBERON:0004912 ! biliary bud +relationship: has_part UBERON:0001246 ! interlobular bile duct +relationship: has_part UBERON:0001282 ! intralobular bile duct +relationship: has_part UBERON:0003703 ! extrahepatic bile duct relationship: part_of UBERON:0002294 ! biliary system property_value: RO:0002171 UBERON:0002110 property_value: UBPROP:0000001 "Hollow tree organ, the organ parts of which consist of the bile ducts.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011020", ontology="AAO", source="UBERON:0001173"} @@ -212987,6 +315874,7 @@ id: UBERON:0001174 name: common bile duct namespace: uberon def: "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." [MGI:csmith, MP:0009495] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -213008,7 +315896,11 @@ xref: VHOG:0000214 xref: Wikipedia:Common_bile_duct xref: ZFA:0005165 is_a: UBERON:0003703 ! extrahepatic bile duct +relationship: channels_into UBERON:0001064 ! ventral pancreatic duct +relationship: continuous_with UBERON:0001152 ! cystic duct +relationship: continuous_with UBERON:0001175 ! common hepatic duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005165", ontology="TAO", source="ZFIN:Curator"} property_value: UBPROP:0000001 "The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000214", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -213032,12 +315924,59 @@ xref: UMLS:C0019149 {source="ncithesaurus:Common_Hepatic_Duct"} xref: VHOG:0000220 xref: Wikipedia:Common_hepatic_duct is_a: UBERON:0003703 {source="FMA"} ! extrahepatic bile duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: continuous_with UBERON:0001176 {source="Wikipedia"} ! right hepatic duct +relationship: continuous_with UBERON:0001177 {source="Wikipedia"} ! left hepatic duct relationship: immediate_transformation_of UBERON:0010081 {evidence="definitional"} ! future common hepatic duct relationship: part_of UBERON:0005604 {source="MA"} ! extrahepatic part of hepatic duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg xsd:anyURI property_value: editor_note "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part" xsd:string property_value: UBPROP:0000001 "The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000220", ontology="VHOG", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001176 +name: right hepatic duct +namespace: uberon +def: "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26034] +synonym: "ductus hepaticus dexter" RELATED LATIN [] +xref: EHDAA2:0001727 +xref: EHDAA:3992 +xref: EMAPA:32797 +xref: FMA:14669 +xref: MA:0001639 +xref: NCIT:C33476 +xref: SCTID:245401008 +xref: UMLS:C0227557 {source="ncithesaurus:Right_Hepatic_Duct"} +xref: VHOG:0000217 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: continuous_with UBERON:0001114 ! right lobe of liver +relationship: continuous_with UBERON:0001114 ! right lobe of liver +relationship: part_of UBERON:0005171 ! hepatic duct +property_value: UBPROP:0000001 "The duct which drains bile from the right half of the liver and unites with the left hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000217", ontology="VHOG", source="http://bgee.unil.ch/"} + +[Term] +id: UBERON:0001177 +name: left hepatic duct +namespace: uberon +def: "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26035] +synonym: "ductus hepaticus sinister" RELATED LATIN [] +xref: EHDAA2:0000941 +xref: EHDAA:3990 +xref: EMAPA:32795 +xref: FMA:14670 +xref: MA:0001638 +xref: NCIT:C32960 +xref: SCTID:245400009 +xref: UMLS:C0227560 {source="ncithesaurus:Left_Hepatic_Duct"} +xref: VHOG:0000218 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: continuous_with UBERON:0001115 ! left lobe of liver +relationship: continuous_with UBERON:0001115 ! left lobe of liver +relationship: part_of UBERON:0005171 ! hepatic duct +property_value: UBPROP:0000001 "The duct which drains bile from the left half of the liver and unites with the right hepatic duct to form the common hepatic duct. [adapted_from_http://www.medterms.com/script/main/art.asp?articlekey=26032][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000218", ontology="VHOG", source="http://bgee.unil.ch/"} + [Term] id: UBERON:0001178 name: visceral peritoneum @@ -213075,7 +316014,7 @@ xref: EMAPA:16138 xref: FMA:14704 xref: GAID:24 xref: MA:0000054 -xref: MESH:A01.047.025.600.678 +xref: MESH:D010529 xref: NCIT:C12769 xref: SCTID:181616008 xref: UMLS:C1704247 {source="ncithesaurus:Peritoneal_Cavity"} @@ -213100,6 +316039,7 @@ id: UBERON:0001182 name: superior mesenteric artery namespace: uberon def: "Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra." [MESH:A07.231.114.565.755] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria mesenterica superior" RELATED LATIN [Wikipedia:Superior_mesenteric_artery] @@ -213122,8 +316062,14 @@ xref: UMLS:C0162861 {source="ncithesaurus:Superior_Mesenteric_Artery"} xref: VHOG:0000754 xref: Wikipedia:Superior_mesenteric_artery is_a: UBERON:0005616 ! mesenteric artery +intersection_of: UBERON:0005616 ! mesenteric artery +intersection_of: supplies UBERON:0002115 ! jejunum +intersection_of: supplies UBERON:0002116 ! ileum +relationship: supplies UBERON:0002115 ! jejunum +relationship: supplies UBERON:0002116 ! ileum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/68/Gray1099.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c0/Superior_mesenteric_a.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon" xsd:string {source="BTO"} [Term] @@ -213131,6 +316077,7 @@ id: UBERON:0001183 name: inferior mesenteric artery namespace: uberon def: "Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_artery] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria mesenterica inferior" RELATED LATIN [Wikipedia:Inferior_mesenteric_artery] @@ -213154,7 +316101,14 @@ xref: VHOG:0001116 xref: Wikipedia:Inferior_mesenteric_artery is_a: UBERON:0005616 ! mesenteric artery is_a: UBERON:0035039 ! rectal artery +intersection_of: UBERON:0005616 ! mesenteric artery +intersection_of: supplies UBERON:0001052 ! rectum +intersection_of: supplies UBERON:0001158 ! descending colon +intersection_of: supplies UBERON:0001159 ! sigmoid colon +relationship: supplies UBERON:0001158 ! descending colon +relationship: supplies UBERON:0001159 ! sigmoid colon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e4/Gray538.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001184 @@ -213162,6 +316116,7 @@ name: renal artery namespace: uberon def: "One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates." [ISBN:0073040584, Wikipedia:Renal_artery] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -213189,8 +316144,12 @@ xref: UMLS:C0035065 {source="ncithesaurus:Renal_Artery"} xref: Wikipedia:Renal_artery xref: ZFA:0000420 is_a: UBERON:0012254 ! abdominal aorta artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002113 ! kidney +relationship: supplies UBERON:0002113 ! kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png xsd:anyURI property_value: editor_note "renal arteries vary widely even in humans. Sub-structures should be checked for taxon variability." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery which supplies blood via branches to the gonads, oviducts, and kidneys.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010223", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The renal arteries normally arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood. Each is directed across the crus of the diaphragm, so as to form nearly a right angle with the aorta. The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys. The arterial supply of the kidneys is variable and there may be one or more renal arteries supplying each kidney. It is located above the renal vein. It has a radius of approximately 0.25cm, 0.26 cm at the root. The measured mean diameter can differ depending on the imaging method used. For example, the diameter was found to be 5.04 ± 0.74 mm using ultrasound, but 5.68 ± 1.19 mm using angiography. [WP,unvetted].[Wikipedia]" xsd:string {ontology="Wikipedia", source="Wikipedia:Renal_artery"} @@ -213200,6 +316159,7 @@ name: right renal artery namespace: uberon def: "Renal artery that supplies the right kidney." [https://orcid.org/0000-0002-6601-2165] comment: The right [renal artery] passes behind the inferior vena cava, the right renal vein, the head of the pancreas, and the descending part of the duodenum[WP] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "right renal arterial tree" EXACT [] @@ -213212,7 +316172,11 @@ xref: OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rveOFHpwpEbGdrcN5Y29ycA xref: SCTID:36800007 xref: UMLS:C0226332 {source="ncithesaurus:Right_Renal_Artery"} is_a: UBERON:0001184 ! renal artery +intersection_of: UBERON:0001184 ! renal artery +intersection_of: supplies UBERON:0004539 ! right kidney +relationship: supplies UBERON:0004539 ! right kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001186 @@ -213220,6 +316184,7 @@ name: left renal artery namespace: uberon def: "Renal artery that supplies the left kidney." [https://orcid.org/0000-0002-6601-2165] comment: The left [renal artery] is somewhat higher than the right; it lies behind the left renal vein, the body of the pancreas and the splenic vein, and is crossed by the inferior mesenteric vein[WP] +subset: human_reference_atlas subset: pheno_slim synonym: "left renal arterial tree" EXACT [] xref: EMAPA:37098 {source="MA:th"} @@ -213231,12 +316196,45 @@ xref: OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rveOFHpwpEbGdrcN5Y29ycA xref: SCTID:19215005 xref: UMLS:C0226333 {source="ncithesaurus:Left_Renal_Artery"} is_a: UBERON:0001184 ! renal artery +intersection_of: UBERON:0001184 ! renal artery +intersection_of: supplies UBERON:0004538 ! left kidney +relationship: supplies UBERON:0004538 ! left kidney +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001187 +name: testicular artery +is_a: UBERON:0010192 ! genital artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0000473 ! testis +relationship: supplies UBERON:0000473 ! testis + +[Term] +id: UBERON:0001188 +name: right testicular artery +is_a: UBERON:0001187 ! testicular artery +is_a: UBERON:0003468 ! ureteric segment of renal artery +intersection_of: UBERON:0001187 ! testicular artery +intersection_of: supplies UBERON:0004534 ! right testis +relationship: supplies UBERON:0001222 ! right ureter +relationship: supplies UBERON:0004534 ! right testis + +[Term] +id: UBERON:0001189 +name: left testicular artery +is_a: UBERON:0001187 ! testicular artery +is_a: UBERON:0003468 ! ureteric segment of renal artery +intersection_of: UBERON:0001187 ! testicular artery +intersection_of: supplies UBERON:0004533 ! left testis +relationship: supplies UBERON:0001223 ! left ureter +relationship: supplies UBERON:0004533 ! left testis [Term] id: UBERON:0001190 name: ovarian artery namespace: uberon def: "An artery that supplies an ovary." [OBOL:automatic] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria ovarica" RELATED LATIN [Wikipedia:Ovarian_artery] synonym: "ovarian arterial tree" EXACT [] @@ -213251,8 +316249,10 @@ xref: Wikipedia:Ovarian_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0000992 ! ovary +relationship: connected_to UBERON:0001516 ! abdominal aorta relationship: supplies UBERON:0000992 ! ovary property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]." xsd:string {source="Wikipedia:Ovarian_artery"} [Term] @@ -213261,6 +316261,7 @@ name: common iliac artery namespace: uberon def: "The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted]." [Wikipedia:Common_iliac_artery] comment: See notes for parent class +subset: human_reference_atlas subset: uberon_slim synonym: "arteria iliaca communis" RELATED LATIN [Wikipedia:Common_iliac_artery] synonym: "common iliac arterial tree" EXACT [] @@ -213277,6 +316278,95 @@ xref: Wikipedia:Common_iliac_artery is_a: UBERON:0005609 {source="MA"} ! iliac artery is_a: UBERON:0012254 ! abdominal aorta artery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6e/Iliac_artery_bifurcation_and_aorta.PNG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001193 +name: hepatic artery +namespace: uberon +def: "An artery that supplies the liver." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Hepatic_artery_proper] +subset: human_reference_atlas +subset: uberon_slim +subset: vertebrate_core +synonym: "arteria hepatica" RELATED [BTO:0004307] +synonym: "arteria hepatica propria" EXACT LATIN [] +xref: BTO:0004307 +xref: EMAPA:17859 +xref: FMA:14769 +xref: GAID:496 +xref: galen:HepaticArtery +xref: MA:0001963 +xref: MESH:D006499 +xref: NCIT:C32729 +xref: OpenCyc:Mx4rvzKtFpwpEbGdrcN5Y29ycA +xref: SCTID:76015000 +xref: TAO:0005161 +xref: UMLS:C0019145 {source="ncithesaurus:Hepatic_Artery"} +xref: ZFA:0005161 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002107 ! liver +relationship: supplies UBERON:0002107 ! liver +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png xsd:anyURI +property_value: IAO:0000232 "currently defined in a generic fashion." xsd:string +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000001 "Artery that supplies blood to the liver.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005161", ontology="TAO", source="ZFIN:curator"} + +[Term] +id: UBERON:0001194 +name: splenic artery +namespace: uberon +def: "An artery that supplies the spleen." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas +subset: uberon_slim +synonym: "arteria lienalis" RELATED LATIN [Wikipedia:Splenic_artery] +synonym: "arteria splenica" EXACT LATIN [Wikipedia:Splenic_artery] +synonym: "lienal artery" EXACT [MA:0001991] +xref: EMAPA:19216 +xref: FMA:14773 +xref: GAID:510 +xref: galen:SplenicArtery +xref: MA:0001991 +xref: MA:0003177 +xref: MESH:D013157 +xref: NCIT:C33597 +xref: OpenCyc:Mx4rv0cb2ZwpEbGdrcN5Y29ycA +xref: SCTID:244266009 +xref: UMLS:C0037996 {source="ncithesaurus:Splenic_Artery"} +xref: Wikipedia:Splenic_artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002106 ! spleen +disjoint_from: UBERON:0001640 ! celiac artery +relationship: branching_part_of UBERON:0001640 ! celiac artery +relationship: supplies UBERON:0002106 ! spleen +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 +property_value: seeAlso https://github.com/obophenotype/uberon/issues/268 xsd:anyURI + +[Term] +id: UBERON:0001196 +name: middle colic artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001182 ! superior mesenteric artery +intersection_of: supplies UBERON:0001157 ! transverse colon +relationship: branching_part_of UBERON:0001182 ! superior mesenteric artery +relationship: supplies UBERON:0001157 ! transverse colon + +[Term] +id: UBERON:0001197 +name: ileocolic artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001182 ! superior mesenteric artery +intersection_of: supplies UBERON:0001153 ! caecum +intersection_of: supplies UBERON:0001154 ! vermiform appendix +intersection_of: supplies UBERON:0002116 ! ileum +relationship: branching_part_of UBERON:0001182 ! superior mesenteric artery +relationship: supplies UBERON:0001153 ! caecum +relationship: supplies UBERON:0001154 ! vermiform appendix +relationship: supplies UBERON:0002116 ! ileum [Term] id: UBERON:0001199 @@ -213314,7 +316404,7 @@ xref: FMA:14907 xref: GAID:321 xref: galen:GastricMucosa xref: MA:0002683 -xref: MESH:A03.492.766.440 +xref: MESH:D005753 xref: NCIT:C32656 xref: OpenCyc:Mx8NhB4rvcD6KJwpEbGdrcN5Y29ycB4rvmKNOpwpEbGdrcN5Y29ycB4rvVj5FpwpEbGdrcN5Y29ycB4rvVjlqpwpEbGdrcN5Y29ycA xref: SCTID:362131005 @@ -213326,7 +316416,7 @@ intersection_of: part_of UBERON:0000945 ! stomach relationship: capable_of GO:0001696 ! gastric acid secretion relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0001167 ! wall of stomach -property_value: depicted:by Wikipedia:File:Normal_gastric_mucosa_intermed_mag.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg xsd:anyURI property_value: UBPROP:0000001 "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]." xsd:string {source="Wikipedia:Gastric_mucosa"} [Term] @@ -213436,6 +316526,11 @@ xref: UMLS:C0227238 {source="ncithesaurus:Pyloric_Sphincter"} xref: VHOG:0001466 xref: XAO:0000457 is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0001166 ! pylorus +relationship: adjacent_to UBERON:0002114 ! duodenum +relationship: continuous_with UBERON:0008858 ! pyloric canal +relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus property_value: RO:0002161 NCBITaxon:8355 property_value: UBPROP:0000003 "(...) the adult Xenopus stomach exhibits both glandular and aglandular regions and a distinct pyloric sphincter similar to that of the amniotic vertebrates (...).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001466", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00076.x", source="http://bgee.unil.ch/"} @@ -213496,8 +316591,62 @@ xref: NCIT:C33568 xref: SCTID:362144000 xref: UMLS:C0227261 {source="ncithesaurus:Small_Intestinal_Mucosa"} is_a: UBERON:0001242 ! intestinal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 ! wall of small intestine +[Term] +id: UBERON:0001205 +name: submucosa of small intestine +namespace: uberon +def: "Submucosal tissue in the small intestines." [Wikipedia:Small_intestinal_submucosa] +subset: uberon_slim +synonym: "small bowel submucosa" EXACT [OBOL:automatic] +synonym: "small intestinal submucosa" EXACT [] +synonym: "small intestine submucosa" EXACT [] +synonym: "submucosa of small bowel" EXACT [OBOL:automatic] +synonym: "tela submucosa (intestinum tenue)" EXACT [] +synonym: "tela submucosa intestini tenuis" EXACT LATIN [BTO:0002112] +xref: BTO:0002112 +xref: EMAPA:37564 {source="MA:th"} +xref: FMA:14934 +xref: MA:0001562 +xref: NCIT:C33572 +xref: SCTID:691000 +xref: UMLS:C0227268 {source="ncithesaurus:Small_Intestinal_Submucosa"} +xref: Wikipedia:Small_intestinal_submucosa +is_a: UBERON:0009566 ! intestinal submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0001168 ! wall of small intestine + +[Term] +id: UBERON:0001206 +name: serosa of small intestine +namespace: uberon +def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +synonym: "serosa of small bowel" EXACT [OBOL:automatic] +synonym: "serous coat of small intestine" EXACT [] +synonym: "serous membrane of small bowel" EXACT [OBOL:automatic] +synonym: "serous membrane of small intestine" EXACT [OBOL:automatic] +synonym: "small bowel serosa" EXACT [OBOL:automatic] +synonym: "small bowel serous membrane" EXACT [OBOL:automatic] +synonym: "small intestinal serosa" EXACT [] +synonym: "small intestine serosa" EXACT [] +synonym: "small intestine serous membrane" EXACT [OBOL:automatic] +synonym: "tunica serosa (intestinum tenue)" EXACT [] +synonym: "tunica serosa intestini tenuis" EXACT LATIN [FMA:14938, FMA:TA] +synonym: "visceral peritoneum of small intestine" EXACT [] +xref: EMAPA:37561 {source="MA:th"} +xref: FMA:14938 +xref: MA:0001558 +xref: SCTID:8266009 +is_a: UBERON:0001243 ! serosa of intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0001168 ! wall of small intestine +property_value: UBPROP:0000010 "duodenum, 1st part serosa, 2nd - 4th adventitia" xsd:string + [Term] id: UBERON:0001207 name: mucosa of large intestine @@ -213588,7 +316737,7 @@ xref: EFO:0001381 xref: EMAPA:19028 xref: GAID:950 xref: MA:0000137 -xref: MESH:A10.549.598 +xref: MESH:D010581 xref: NCIT:C12771 xref: UMLS:C0031272 {source="ncithesaurus:Peyer_s_Patch"} xref: Wikipedia:Peyer's_patch @@ -213618,13 +316767,17 @@ xref: EMAPA:36522 xref: FMA:15060 xref: GAID:314 xref: MA:0001551 -xref: MESH:A03.492.411.620.270.322 +xref: MESH:D002011 xref: NCIT:C13010 xref: SCTID:41298001 xref: UMLS:C0006323 {source="ncithesaurus:Brunner_s_Gland"} xref: Wikipedia:Brunner's_glands is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0011148 {notes="compound tubular"} ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: located_in UBERON:0003332 {source="FMA, modified"} ! submucosa of duodenum +relationship: only_in_taxon NCBITaxon:40674 {notes="unclear for Aves", source="ISBN:9780521617147"} ! Mammalia relationship: part_of UBERON:0002114 ! duodenum property_value: editor_note "currently defined as equivalent to any submucosal gland in the duodenum." xsd:string property_value: UBPROP:0000008 "Said to be absent outside mammlian (Andrew 1959) but Ziswiler and Farner (1972) noted similar glands at the gastroduodenal junction of some birds" xsd:string {source="ISBN:9780521617147"} @@ -213660,6 +316813,8 @@ xref: Wikipedia:Intestinal_villus xref: ZFA:0005125 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 {source="FMA"} ! organ component layer +relationship: has_part UBERON:0001981 ! blood vessel +relationship: has_part UBERON:0012425 ! striated border microvillus layer relationship: part_of UBERON:0001277 {source="ZFA"} ! intestinal epithelium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg xsd:anyURI property_value: editor_note "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine" xsd:string @@ -213670,9 +316825,12 @@ property_value: UBPROP:0000012 "the BTO class refers to a generic villous" xsd:s id: UBERON:0001215 name: inferior mesenteric vein namespace: uberon +def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_vein] def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [http://en.wikipedia.org/wiki/Inferior_mesenteric_vein] +subset: human_reference_atlas subset: uberon_slim synonym: "lower mesenteric vein" RELATED [BTO:0002782] +synonym: "vena mesenterica inferior" RELATED LATIN [Wikipedia:Inferior_mesenteric_vein] synonym: "vena mesenterica inferior" RELATED LATIN [http://en.wikipedia.org/wiki/Inferior_mesenteric_vein] xref: BTO:0002782 xref: EHDAA2:0000819 @@ -213685,8 +316843,10 @@ xref: http://www.snomedbrowser.com/Codes/Details/281055007 xref: MA:0002178 xref: NCIT:C32782 xref: OpenCyc:Mx4rvcV53ZwpEbGdrcN5Y29ycA +xref: SCTID:281055007 xref: UMLS:C0226754 {source="ncithesaurus:Inferior_Mesenteric_Vein"} xref: VHOG:0001118 +xref: Wikipedia:Inferior_mesenteric_vein is_a: UBERON:0005617 ! mesenteric vein intersection_of: UBERON:0005617 ! mesenteric vein intersection_of: drains UBERON:0000059 ! large intestine @@ -213694,6 +316854,64 @@ relationship: drains UBERON:0000059 ! large intestine relationship: part_of UBERON:0003713 ! splenic vein relationship: tributary_of UBERON:0003713 {source="FMA/obol"} ! splenic vein property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001216 +name: jejunal vein +is_a: UBERON:0002017 ! portal vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002115 ! jejunum +relationship: drains UBERON:0002115 ! jejunum +relationship: tributary_of UBERON:0001138 ! superior mesenteric vein + +[Term] +id: UBERON:0001217 +name: ileal vein +is_a: UBERON:0002017 ! portal vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002116 ! ileum +relationship: drains UBERON:0002116 ! ileum +relationship: part_of UBERON:0001138 ! superior mesenteric vein +relationship: tributary_of UBERON:0001138 ! superior mesenteric vein + +[Term] +id: UBERON:0001218 +name: middle colic vein +is_a: UBERON:0002017 ! portal vein +intersection_of: UBERON:0002017 ! portal vein +intersection_of: drains UBERON:0001157 ! transverse colon +intersection_of: tributary_of UBERON:0001138 ! superior mesenteric vein +relationship: drains UBERON:0001157 ! transverse colon +relationship: tributary_of UBERON:0001138 ! superior mesenteric vein + +[Term] +id: UBERON:0001219 +name: ileocolic vein +is_a: UBERON:0001217 ! ileal vein +intersection_of: UBERON:0002017 ! portal vein +intersection_of: drains UBERON:0001153 ! caecum +intersection_of: drains UBERON:0001155 ! colon +intersection_of: drains UBERON:0002116 ! ileum +intersection_of: tributary_of UBERON:0001138 ! superior mesenteric vein +relationship: drains UBERON:0001153 ! caecum +relationship: drains UBERON:0001155 ! colon + +[Term] +id: UBERON:0001222 +name: right ureter +is_a: UBERON:0000056 ! ureter +intersection_of: UBERON:0000056 ! ureter +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0001223 +name: left ureter +is_a: UBERON:0000056 ! ureter +intersection_of: UBERON:0000056 ! ureter +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism [Term] id: UBERON:0001224 @@ -213701,6 +316919,7 @@ name: renal pelvis namespace: uberon def: "A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]." [MP:0004194] comment: In this ontology, the renal pelvis is represented as the area of part-overlap between the kidney and the ureter +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney pelvis" EXACT [] @@ -213733,13 +316952,16 @@ relationship: continuous_with UBERON:0000056 {source="FMA"} ! ureter relationship: contributes_to_morphology_of UBERON:0000056 ! ureter relationship: part_of UBERON:0002113 {source="MA"} ! kidney relationship: part_of UBERON:0036295 ! renal pelvis/ureter +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg xsd:anyURI property_value: depicted:by Illu:kidney2.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001225 name: cortex of kidney namespace: uberon def: "Outer cortical portion of the kidney, between the renal capsule and the renal medulla." [Wikipedia:Renal_cortex] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex renalis" EXACT LATIN [FMA:15581, FMA:TA] @@ -213759,8 +316981,12 @@ xref: UMLS:C0022655 {source="ncithesaurus:Renal_Cortex"} xref: Wikipedia:Renal_cortex is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001851 ! cortex +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0002113 ! kidney +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0008987 {source="FMA"} ! renal parenchyma -property_value: depicted:by Illu:kidney.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "In the adult metanephros, it forms a continuous smooth outer zone with a number of projections that extend down between the pyramids. It contains the renal corpuscles and the renal tubules except for parts of the loop of Henle which descend into the renal medulla. It also contains blood vessels and cortical collecting ducts. The renal cortex is the part of the kidney where ultrafiltration occurs.[WP]" xsd:string [Term] @@ -213768,6 +316994,7 @@ id: UBERON:0001228 name: renal papilla namespace: uberon def: "Tip of renal pyramid projecting into a minor calyx." [http://anatomy.uams.edu/anatomyhtml/kidney.html] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "kidney papilla" EXACT [MP:0011303] @@ -213783,9 +317010,11 @@ xref: UMLS:C0022666 {source="ncithesaurus:Renal_Papilla"} xref: Wikipedia:Renal_papilla is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: contributes_to_morphology_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001294 ! inner medulla of kidney -property_value: depicted:by Kidney:PioM.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001229 @@ -213793,6 +317022,7 @@ name: renal corpuscle namespace: uberon def: "The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron." [ISBN:0-683-40008-8, MP:0002827] comment: Together, the Bowmans capsule and the glomerulus comprise the definitive renal corpuscle. http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -213818,9 +317048,12 @@ xref: Wikipedia:Renal_corpuscle xref: ZFA:0005281 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000063 ! organ subunit +relationship: contributes_to_morphology_of UBERON:0001225 ! cortex of kidney +relationship: contributes_to_morphology_of UBERON:0001285 ! nephron relationship: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001285 {source="MA", source="ZFA"} ! nephron -property_value: depicted:by Renal:corpuscle.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney[BTO]" xsd:string {date_retrieved="2012-11-28", external_class="BTO:0000333", ontology="BTO", source="BTO:curator"} property_value: UBPROP:0000001 "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated. Paired highly vascularized structures of the pronephros, responsible for blood filtration.[XAO]" xsd:string {date_retrieved="2012-11-28", external_class="XAO:0000146", ontology="XAO", source="XAO:curator"} property_value: UBPROP:0000001 "The part of the nephron that filters blood.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005281", ontology="TAO", source="ZFIN:curator"} @@ -213839,7 +317072,7 @@ synonym: "Bowmans capsule" EXACT [KUPO:0001001] synonym: "capsula glomerularis" EXACT LATIN [] synonym: "capsula glomeruli" RELATED LATIN [] synonym: "Malphigian capsule" RELATED MISSPELLING [BTO:0002297] -synonym: "Malpighian capsule" RELATED [UBERO:cjm] +synonym: "Malpighian capsule" RELATED [UBERON:cjm] synonym: "Mueller capsule" RELATED [BTO:0002297] synonym: "Muellerian capsule" RELATED [BTO:0002297] synonym: "pronephric glomerular capsule" RELATED [TAO:0005310] @@ -213861,6 +317094,9 @@ xref: ZFA:0005254 xref: ZFA:0005310 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +disjoint_from: UBERON:0002015 ! kidney capsule +relationship: capable_of_part_of GO:0003094 ! glomerular filtration +relationship: contributes_to_morphology_of UBERON:0001229 ! renal corpuscle relationship: develops_from UBERON:0004199 ! S-shaped body relationship: part_of UBERON:0001229 ! renal corpuscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg xsd:anyURI @@ -213875,6 +317111,7 @@ namespace: uberon alt_id: UBERON:0004210 def: "An epithelial tube that is part of the nephron, the functional part of the kidney." [GO:0072078, Wikipedia:Renal_tubule] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -213899,7 +317136,9 @@ xref: Wikipedia:Renal_tubule xref: ZFA:0001287 is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0009773 {source="GO"} ! renal tubule +relationship: contributes_to_morphology_of UBERON:0001285 ! nephron relationship: develops_from UBERON:0003918 {notes="checkme"} ! kidney mesenchyme +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "note that in ISBN:0073040584 (Vertebrates, Kardong), the uriniferous tubule contains the nephron, so we have a separate class, rather than using a synonym, as in MA" xsd:string {external_ontology="MA"} [Term] @@ -213907,6 +317146,7 @@ id: UBERON:0001232 name: collecting duct of renal tubule namespace: uberon def: "The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient." [GO:0072044, Wikipedia:Collecting_tubule] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -213935,11 +317175,29 @@ xref: Wikipedia:Collecting_tubule xref: ZFA:0005294 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0006555 ! excretory tube +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0001285 {notes="checkme", source="GO"} ! nephron relationship: part_of UBERON:0004100 ! renal collecting system +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Renal duct that collects the output from renal tubules.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005294", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000012 "in ISBN:0073040584 (Vertebrates, Kardong), the nephron is adjacent to the collecting tubule, consistent with FMA, but not GO. Wikipedia says: Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0001233 +name: right adrenal gland +is_a: UBERON:0002369 ! adrenal gland +intersection_of: UBERON:0002369 ! adrenal gland +intersection_of: in_right_side_of UBERON:0000916 ! abdomen +relationship: in_right_side_of UBERON:0000916 ! abdomen + +[Term] +id: UBERON:0001234 +name: left adrenal gland +is_a: UBERON:0002369 ! adrenal gland +intersection_of: UBERON:0002369 ! adrenal gland +intersection_of: in_left_side_of UBERON:0000916 ! abdomen +relationship: in_left_side_of UBERON:0000916 ! abdomen + [Term] id: UBERON:0001235 name: adrenal cortex @@ -213976,6 +317234,12 @@ xref: XAO:0000165 is_a: UBERON:0001851 ! cortex is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0002369 ! adrenal gland +relationship: capable_of GO:0006704 ! glucocorticoid biosynthetic process +relationship: capable_of GO:0006705 ! mineralocorticoid biosynthetic process +relationship: capable_of GO:0035932 ! aldosterone secretion +relationship: contributes_to_morphology_of UBERON:0002369 ! adrenal gland relationship: part_of UBERON:0002369 ! adrenal gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png xsd:anyURI property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001481", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"} @@ -214018,10 +317282,43 @@ xref: XAO:0000166 is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0002369 ! adrenal gland +relationship: contributes_to_morphology_of UBERON:0002369 ! adrenal gland +relationship: has_part CL:1000426 ! chromaffin cell of adrenal gland relationship: part_of UBERON:0002369 ! adrenal gland +relationship: surrounded_by UBERON:0001235 ! adrenal cortex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png xsd:anyURI property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001378", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001238 +name: lamina propria of small intestine +namespace: uberon +def: "Lamina propria that is part_of the small intestine." [GOC:Obol] +synonym: "lamina propria mucosa of small bowel" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of small intestine" EXACT [OBOL:automatic] +synonym: "lamina propria mucosae of small bowel" EXACT [OBOL:automatic] +synonym: "lamina propria mucosae of small intestine" EXACT [] +synonym: "lamina propria of mucosa of small intestine" EXACT [] +synonym: "lamina propria of small bowel" EXACT [OBOL:automatic] +synonym: "small bowel lamina propria" EXACT [OBOL:automatic] +synonym: "small bowel lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "small bowel lamina propria mucosae" EXACT [OBOL:automatic] +synonym: "small intestine lamina propria" EXACT [] +synonym: "small intestine lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "small intestine lamina propria mucosae" EXACT [OBOL:automatic] +xref: EMAPA:35779 +xref: FMA:15651 +xref: MA:0001554 +xref: NCIT:C49297 +xref: SCTID:63588008 +xref: UMLS:C1711325 {source="ncithesaurus:Small_Intestinal_Lamina_Propria"} +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0001204 ! mucosa of small intestine + [Term] id: UBERON:0001241 name: crypt of Lieberkuhn of small intestine @@ -214082,6 +317379,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0021839 xref: http://www.snomedbrowser.com/Codes/Details/362080002 xref: MA:0001537 xref: MESH:A03.492.411.369 +xref: MESH:D007413 xref: NCIT:C49241 xref: SCTID:362080002 xref: UMLS:C0021839 {source="ncithesaurus:Intestinal_Mucosa"} @@ -214172,6 +317470,7 @@ name: anus namespace: uberon def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [Wikipedia:Anus, ZFIN:curator] def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [http://en.wikipedia.org/wiki/Anus, ZFIN:curator] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "anal opening" EXACT [] @@ -214182,6 +317481,7 @@ xref: BTO:0001680 xref: CALOHA:TS-2005 xref: EV:0100082 xref: FBbt:00003148 +xref: FBbt:00047153 xref: FMA:15711 xref: GAID:312 xref: galen:Anus @@ -214207,6 +317507,7 @@ relationship: distalmost_part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "anal" xsd:string property_value: UBPROP:0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" xsd:string @@ -214224,8 +317525,24 @@ xref: SCTID:83488001 xref: UMLS:C0227515 {source="ncithesaurus:Interlobular_Bile_Duct"} xref: Wikipedia:Interlobular_bile_ducts is_a: UBERON:0003704 {source="FMA", source="MA-part-of"} ! intrahepatic bile duct +relationship: connects UBERON:0004058 ! biliary ductule +relationship: connects UBERON:0014719 ! intralobular duct +relationship: contributes_to_morphology_of UBERON:0001279 ! portal triad relationship: part_of UBERON:0001279 {source="FMA", source="MA", source="MP"} ! portal triad +[Term] +id: UBERON:0001247 +name: falciform ligament +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0013139 ! ligament of liver +intersection_of: UBERON:0008845 ! nonskeletal ligament +intersection_of: attaches_to UBERON:0000309 ! body wall +intersection_of: attaches_to UBERON:0002107 ! liver +relationship: attaches_to UBERON:0000309 ! body wall +relationship: attaches_to UBERON:0002107 ! liver +relationship: part_of UBERON:0005626 ! ventral mesogastrium + [Term] id: UBERON:0001249 name: spleen lymphoid follicle @@ -214258,6 +317575,7 @@ id: UBERON:0001250 name: red pulp of spleen namespace: uberon def: "The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation." [MGI:csmith, MP:0002356] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pulpa rubra" EXACT LATIN [FMA:15844, FMA:TA] @@ -214274,14 +317592,18 @@ xref: SCTID:27579002 xref: UMLS:C0229687 {source="ncithesaurus:Splenic_Red_Pulp"} xref: Wikipedia:Red_pulp is_a: UBERON:1000023 ! spleen pulp +relationship: composed_primarily_of CL:0000542 ! lymphocyte +relationship: contributes_to_morphology_of UBERON:0002106 ! spleen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001251 name: marginal zone of spleen namespace: uberon def: "The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens." [ISBN:0-683-40008-8, MP:0002362] +subset: human_reference_atlas subset: pheno_slim synonym: "junctional zone of spleen" EXACT [] synonym: "marginal zone" BROAD [Wikipedia:Marginal_zone] @@ -214295,8 +317617,11 @@ xref: UMLS:C1711368 {source="ncithesaurus:Marginal_Zone"} xref: Wikipedia:Marginal_zone is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: adjacent_to UBERON:0001250 ! red pulp of spleen +relationship: adjacent_to UBERON:0001959 ! white pulp of spleen relationship: part_of UBERON:0002106 ! spleen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line." xsd:string {external_ontology="FMA"} [Term] @@ -214345,6 +317670,7 @@ id: UBERON:0001254 name: urothelium of ureter namespace: uberon def: "The luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder[MP]." [MP:0000535] +subset: human_reference_atlas subset: pheno_slim synonym: "transitional epithelium of ureter" EXACT [] synonym: "ureter luminal urothelium" RELATED INCONSISTENT [MP:0000535] @@ -214356,7 +317682,11 @@ xref: MA:0002655 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000365 ! urothelium +intersection_of: part_of UBERON:0000056 ! ureter +relationship: contributes_to_morphology_of UBERON:0000056 ! ureter relationship: part_of UBERON:0000056 ! ureter +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "MP treats ureter urothelium and ureter luminal urothelium as exact synonyms, yes MA treats these as distinct; see also: transitional epithelium vs urothelium" xsd:string {external_ontology="MP"} [Term] @@ -214366,6 +317696,7 @@ namespace: uberon def: "Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." [MGI:anna, Wikipedia:Urinary_bladder] def: "distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]." [http://en.wikipedia.org/wiki/Urinary_bladder, MGI:anna] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -214392,6 +317723,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/302512001 xref: MA:0000380 xref: MAT:0000122 xref: MESH:A05.810.161 +xref: MESH:D001743 xref: MIAA:0000122 xref: NCIT:C12414 xref: OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA @@ -214406,8 +317738,10 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0018707 {source="BTO"} ! bladder organ relationship: develops_from UBERON:0000164 {notes="upper part of UG sinus"} ! primitive urogenital sinus relationship: part_of UBERON:0001556 {source="FMA"} ! lower urinary tract +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg xsd:anyURI property_value: depicted:by Urinary:system.svg xsd:anyURI -property_value: RO:0002161 NCBITaxon:8782 {editor="BGEE:Ann", id="GOTAX:0010073", source="https://github.com/obophenotype/uberon/issues/454"} +property_value: RO:0002161 NCBITaxon:8782 {editor="https://orcid.org/0000-0003-3308-6245", id="GOTAX:0010073", source="https://github.com/obophenotype/uberon/issues/454"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000740", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000740", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000623", ontology="AAO", source="AAO:BJB"} @@ -214421,6 +317755,7 @@ id: UBERON:0001256 name: wall of urinary bladder namespace: uberon def: "An anatomical wall that lines the insider of a urinary bladder." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim synonym: "anatomical wall of bladder" EXACT [OBOL:automatic] synonym: "anatomical wall of urinary bladder" EXACT [OBOL:automatic] @@ -214443,12 +317778,14 @@ is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001257 name: trigone of urinary bladder namespace: uberon def: "The smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa." [MGI:anna, MP:0011768] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bladder trigone" EXACT [] @@ -214471,8 +317808,10 @@ xref: UMLS:C0447586 {source="ncithesaurus:Bladder_Trigone"} xref: Wikipedia:Trigone_of_urinary_bladder is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0006082 ! fundus of urinary bladder -property_value: depicted:by Illu:bladder.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "The area is very sensitive to expansion and once stretched to a certain degree, the urinary bladder signals the brain of its need to empty. The signals become stronger as the bladder continues to fill." xsd:string property_value: UBPROP:0000011 "Embryologically, the trigone of the bladder is derived from the caudal end of mesonephric ducts, which is of mesodermal origin (the rest of the bladder is endodermal). In the female the mesonephric ducts regresses, causing the trigone to be less prominent, but still present" xsd:string {source="WP"} @@ -214500,6 +317839,9 @@ xref: UMLS:C0227716 {source="ncithesaurus:Bladder_Neck"} xref: Wikipedia:Neck_of_urinary_bladder is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0001255 ! urinary bladder +relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png xsd:anyURI @@ -214510,6 +317852,7 @@ namespace: uberon def: "the mucous membrane lining the urinary bladder" [MGI:anna, MP:0011766] def: "The mucous membrane lining the urinary bladder." [MGI:anna, MP:0011766] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim synonym: "bladder mucosa" EXACT [] synonym: "bladder mucous membrane" EXACT [OBOL:automatic] @@ -214538,6 +317881,7 @@ intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 ! wall of urinary bladder +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001260 @@ -214628,10 +317972,11 @@ id: UBERON:0001263 name: pancreatic acinus namespace: uberon def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [MP:0009145] +subset: human_reference_atlas subset: pheno_slim synonym: "acinus pancreaticus" EXACT LATIN [FMA:16011] synonym: "pancreas acinus" EXACT [] -synonym: "pancreatic acinar" RELATED [TEMP:MP] +synonym: "pancreatic acinar" RELATED [] synonym: "pancreatic acini" RELATED PLURAL [] xref: EMAPA:35651 xref: FMA:16011 @@ -214641,7 +317986,12 @@ xref: SCTID:247604006 xref: UMLS:C0227578 {source="ncithesaurus:Pancreatic_Acinus"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013232 ! serous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0000017 ! exocrine pancreas +relationship: composed_primarily_of CL:0002064 ! pancreatic acinar cell +relationship: contributes_to_morphology_of UBERON:0000017 ! exocrine pancreas relationship: part_of UBERON:0007324 {source="FMA"} ! pancreatic lobule +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001264 @@ -214649,6 +317999,7 @@ name: pancreas namespace: uberon def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]." [GO:0031016] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -214678,8 +318029,15 @@ xref: VHOG:0000050 xref: Wikipedia:Pancreas xref: XAO:0000136 xref: ZFA:0000140 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002075 ! viscus +relationship: has_developmental_contribution_from UBERON:0003923 {source="Wikipedia"} ! dorsal pancreatic bud +relationship: has_developmental_contribution_from UBERON:0003924 {source="Wikipedia"} ! ventral pancreatic bud +relationship: has_part UBERON:0000016 ! endocrine pancreas +relationship: has_part UBERON:0000017 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! exocrine pancreas +relationship: only_in_taxon NCBITaxon:7742 {source="PMID:16417468"} ! Vertebrata property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010112", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000050", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "pancreatic" xsd:string @@ -214692,8 +318050,10 @@ id: UBERON:0001265 name: trabecula of spleen namespace: uberon def: "A trabecula that is part of a spleen." [OBOL:automatic] +subset: human_reference_atlas synonym: "spleen trabeculum" EXACT [] synonym: "splenic trabecula" EXACT [] +synonym: "trabeculae of spleen" EXACT PLURAL [] xref: EMAPA:35808 xref: FMA:16027 xref: MA:0000758 @@ -214703,7 +318063,10 @@ xref: UMLS:C0229688 {source="ncithesaurus:Splenic_Trabecula"} xref: Wikipedia:Trabeculae_of_spleen is_a: UBERON:0000440 ! trabecula is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:1000024 {source="FMA"} ! parenchyma of spleen +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001268 @@ -214740,7 +318103,7 @@ xref: EMAPA:18346 xref: FMA:16579 xref: GAID:206 xref: MA:0001335 -xref: MESH:A02.835.232.611.108 +xref: MESH:D000077 xref: NCIT:C32042 xref: OpenCyc:Mx4rwJlP9ZwpEbGdrcN5Y29ycA xref: RETIRED_EHDAA2:0001427 @@ -214767,7 +318130,12 @@ synonym: "pelvis ossea" EXACT [] synonym: "skeletal system of pelvis" EXACT [FMA:16580] xref: FMA:16580 xref: SCTID:46633002 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system +disjoint_from: UBERON:0002355 ! pelvic region of trunk +relationship: has_part UBERON:0001274 ! ischium +relationship: has_part UBERON:0001275 ! pubis +relationship: has_part UBERON:0003690 ! fused sacrum property_value: editor_note "TODO add taxon-specific part of relations connecting sub-structures to this." xsd:string property_value: UBPROP:0000012 "in FMA, this is part of the axial skeletal system" xsd:string {external_ontology="FMA"} @@ -214776,7 +318144,7 @@ id: UBERON:0001271 name: pelvic girdle region namespace: uberon def: "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [FMA:16581, FMA:23217, https://doi.org/10.1002/dvdy.22617, https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] -def: "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [DOI:10.1002/dvdy.22617, FMA:16581, FMA:23217, https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +def: "The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions." [DOI:10.1002/dvdy.22617, FMA:16581, FMA:23217, https://groups.google.com/d/topic/obo-anatomy/h4R4xKmINrw/discussion, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] subset: uberon_slim subset: vertebrate_core synonym: "girdle - pelvic" RELATED [] @@ -214806,7 +318174,7 @@ property_value: UBPROP:0000001 "Subdivision of lower limb or fin which links the id: UBERON:0001272 name: innominate bone namespace: uberon -def: "A fused bone consisting of the ilium, ischium and and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]." [https://github.com/obophenotype/uberon/issues/290, https://orcid.org/0000-0002-6601-2165, Wikipedia:Hip_bone] +def: "A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]." [https://github.com/obophenotype/uberon/issues/290, https://orcid.org/0000-0002-6601-2165, Wikipedia:Hip_bone] subset: uberon_slim synonym: "basipterygium" RELATED [] synonym: "bone of pelvic girdle" BROAD [FMA:16585] @@ -214820,12 +318188,12 @@ synonym: "os innominatum" RELATED LATIN [Wikipedia:Hip_bone] synonym: "pelvic bone" EXACT [FMA:16585] xref: FMA:16585 xref: GAID:205 -xref: MESH:A02.835.232.611 xref: SCTID:361776002 xref: Wikipedia:Hip_bone is_a: UBERON:0007830 ! pelvic girdle bone/zone is_a: UBERON:0010428 {source="FMA"} ! flat bone is_a: UBERON:0015212 ! lateral structure +relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton relationship: part_of UBERON:0001464 {source="FMA"} ! hip property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png xsd:anyURI property_value: editor_note "currently this class is restricted to exclude the teleost bone as the definition mentions ilium, ischium and pubis. In future we may add a grouping class for girdle bones that supports the appendage" xsd:string @@ -214854,7 +318222,7 @@ xref: FMA:16589 xref: GAID:207 xref: galen:Ilium xref: MA:0001336 -xref: MESH:A02.835.232.611.434 +xref: MESH:D007085 xref: NCIT:C32765 xref: OpenCyc:Mx4rvhwFJ5wpEbGdrcN5Y29ycA xref: SCTID:182029005 @@ -214864,7 +318232,11 @@ is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0007830 ! pelvic girdle bone/zone is_a: UBERON:0015054 ! iliac endochondral element is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0015054 ! iliac endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: contributes_to_morphology_of UBERON:0007830 ! pelvic girdle bone/zone relationship: develops_from UBERON:0010714 {source="cjm"} ! iliac cartilage element +relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton relationship: part_of UBERON:0001272 {source="FMA"} ! innominate bone property_value: RO:0002161 NCBITaxon:32443 {source="Wikipedia"} property_value: RO:0002174 NCBITaxon:8570 {source="Wikipedia"} @@ -214890,7 +318262,7 @@ xref: FMA:16592 xref: GAID:208 xref: galen:Ischium xref: MA:0001337 -xref: MESH:A02.835.232.611.548 +xref: MESH:D007512 xref: NCIT:C32884 xref: OpenCyc:Mx4rvlzMKpwpEbGdrcN5Y29ycA xref: SCTID:182025004 @@ -214902,7 +318274,11 @@ is_a: UBERON:0007830 {source="MA"} ! pelvic girdle bone/zone is_a: UBERON:0008202 {source="MA"} ! bone of hip region is_a: UBERON:0015056 ! ischial endochondral element is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0015056 ! ischial endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: contributes_to_morphology_of UBERON:0007830 ! pelvic girdle bone/zone relationship: develops_from UBERON:0006254 {source="cjm"} ! ischial cartilage element +relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton relationship: part_of UBERON:0001272 ! innominate bone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg xsd:anyURI property_value: UBPROP:0000001 "Paired bones of endochondral origin that constitute the posterior elements of the pelvic girdle. They are synostotically fused to each other and form the posterior part of the acetabulum.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000860", ontology="AAO", source="AAO:LAP"} @@ -214924,7 +318300,7 @@ xref: EMAPA:18728 xref: FMA:16595 xref: galen:Pubis xref: MA:0001338 -xref: MESH:A02.835.232.611.781 +xref: MESH:D011630 xref: NCIT:C33423 xref: SCTID:182035005 xref: UMLS:C0034014 {source="ncithesaurus:Pubic_Bone"} @@ -214934,7 +318310,11 @@ is_a: UBERON:0007830 {source="MA"} ! pelvic girdle bone/zone is_a: UBERON:0008202 {source="MA"} ! bone of hip region is_a: UBERON:0015055 ! pubic endochondral element is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0015055 ! pubic endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: contributes_to_morphology_of UBERON:0007830 ! pelvic girdle bone/zone relationship: develops_from UBERON:0010718 ! pubic cartilage element +relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton relationship: part_of UBERON:0001272 {source="FMA"} ! innominate bone property_value: UBPROP:0000001 "Paired, cartilaginous (ocassionally calcified) elements that form the ventral portion of the pelvic girdle. Each is located ventral to the acetabulum between the anteroventral margin of the ischium and the posteroventral margin of the illium. When the element calcifies or ossifies, its articulation with adjacent elements is difficult to distinguish. Both pubes are synchondrotically fused to one another.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000861", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000012 "isa bone zone in FMA" xsd:string {external_ontology="FMA"} @@ -215034,6 +318414,7 @@ id: UBERON:0001279 name: portal triad namespace: uberon def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:csmith, MP:0008993] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "trias hepatica" EXACT [] @@ -215046,8 +318427,13 @@ xref: UMLS:C0227514 {source="ncithesaurus:Portal_Triad"} xref: Wikipedia:Portal_triad is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0034921 ! multi organ part structure +relationship: contributes_to_morphology_of UBERON:0001171 ! portal lobule +relationship: has_part UBERON:0001193 ! hepatic artery +relationship: has_part UBERON:0002017 ! portal vein +relationship: has_part UBERON:0003704 ! intrahepatic bile duct relationship: part_of UBERON:0001172 ! hepatic acinus -property_value: depicted:by Portal:triad.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000013 "The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver." xsd:string [Term] @@ -215074,6 +318460,9 @@ xref: VHOG:0000539 xref: XAO:0000454 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0002107 ! liver +relationship: contributes_to_morphology_of UBERON:0002107 ! liver relationship: develops_from UBERON:0008835 {source="XAO"} ! hepatic diverticulum relationship: part_of UBERON:0002107 ! liver property_value: UBPROP:0000003 "the (liver) tubular structure (dual layered parenchyma) appears to be conserved among all embryonic vertebrates (...) it is not unlikely that all vertebrate livers share the same fundamental functional unit.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000539", ontology="VHOG", source="DOI:10.1002/ar.20524 Hardman RC, Volz DC, Kullman SW, Hinton DE, An in vivo look at vertebrate liver architecture: three-dimensional reconstruction from Medaka (Oryzias latipes). The Anatomical Record (2007)", source="http://bgee.unil.ch/"} @@ -215084,6 +318473,7 @@ name: hepatic sinusoid namespace: uberon alt_id: UBERON:0003275 def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [Wikipedia:Hepatic_sinusoid, ZFIN:curator] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -215109,8 +318499,14 @@ xref: ZFA:0005091 is_a: UBERON:0003909 ! sinusoid is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0003909 ! sinusoid +intersection_of: part_of UBERON:0002107 ! liver +relationship: connected_to UBERON:0006841 ! central vein of liver +relationship: contributes_to_morphology_of UBERON:0004647 ! liver lobule +relationship: develops_in UBERON:0001113 ! lobe of liver relationship: part_of UBERON:0004647 ! liver lobule relationship: part_of UBERON:0006877 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! vasculature of liver +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000708", ontology="VHOG", source="DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", source="http://bgee.unil.ch/"} [Term] @@ -215118,6 +318514,7 @@ id: UBERON:0001282 name: intralobular bile duct namespace: uberon def: "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." [MGI:csmith, MP:0009499] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "canal of Hering" RELATED [] @@ -215136,9 +318533,13 @@ xref: UMLS:C0227517 {source="ncithesaurus:Canal_of_Hering"} xref: Wikipedia:Canals_of_Hering is_a: UBERON:0003704 {source="FMA"} ! intrahepatic bile duct is_a: UBERON:0014716 ! interlobular duct +relationship: contributes_to_morphology_of UBERON:0004647 ! liver lobule +relationship: has_part CL:0000182 ! hepatocyte +relationship: has_part CL:1000488 ! cholangiocyte relationship: part_of UBERON:0001172 {source="FMA"} ! hepatic acinus relationship: part_of UBERON:0004647 {source="FMA"} ! liver lobule property_value: editor_note "Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct)" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001283 @@ -215176,6 +318577,7 @@ id: UBERON:0001285 name: nephron namespace: uberon def: "The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]." [PMID:9268568, Wikipedia:Nephron] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -215199,11 +318601,13 @@ xref: Wikipedia:Nephron xref: ZFA:0005282 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: develops_from UBERON:0004208 {evidence="definitional"} ! nephrogenic mesenchyme relationship: immediate_transformation_of UBERON:0010532 {source="Bgee:AN"} ! primitive nephron relationship: part_of UBERON:0007684 {source="FMA"} ! uriniferous tubule property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI property_value: editor_note "kidney terms require review for cross-vertebrate compatibility and developmental relationships." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Functional unit of the kidney that filters waste.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002153", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "In the avian kidney, three types of nephron are identified: mammalian-type nephrons with long and short loops of Henle, and reptilian type nephrons (Gambaryan, 1992)" xsd:string {source="GO"} @@ -215276,6 +318680,9 @@ xref: ZFA:0005290 is_a: UBERON:0006534 {source="MA"} ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0012275 ! meso-epithelium +relationship: continuous_with UBERON:0001230 ! glomerular capsule +relationship: continuous_with UBERON:0001290 ! proximal straight tubule +relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule relationship: develops_from UBERON:0003220 {source="Wikipedia"} ! metanephric mesenchyme relationship: part_of UBERON:0004134 {notes="MA uses subclass", source="GOC:mtg_kidney_jan10"} ! proximal tubule property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI @@ -215304,6 +318711,12 @@ xref: UMLS:C0023986 {source="ncithesaurus:Loop_of_Henle"} xref: VHOG:0001270 xref: Wikipedia:Loop_of_Henle is_a: UBERON:0007685 ! region of nephron tubule +intersection_of: UBERON:0007685 ! region of nephron tubule +intersection_of: continuous_with UBERON:0001287 ! proximal convoluted tubule +intersection_of: continuous_with UBERON:0001292 ! distal convoluted tubule +relationship: continuous_with UBERON:0001287 ! proximal convoluted tubule +relationship: continuous_with UBERON:0001292 ! distal convoluted tubule +relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI property_value: editor_note "the definitions of some kidney parts (e.g. proximal straight tubule) refer to Henle's loop, even in species where this may not be present. Requires review." xsd:string property_value: RO:0002174 NCBITaxon:8353 @@ -215317,6 +318730,7 @@ id: UBERON:0001289 name: descending limb of loop of Henle namespace: uberon def: "The portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure." [MGI:anna, MP:0011341] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "descending limb" BROAD [] @@ -215330,14 +318744,28 @@ xref: SCTID:245350001 xref: UMLS:C0227657 {source="ncithesaurus:Descending_Limb_of_the_Henle_s_Loop"} xref: Wikipedia:Descending_limb_of_loop_of_henle is_a: UBERON:0007685 {source="FMA"} ! region of nephron tubule +relationship: contributes_to_morphology_of UBERON:0001288 ! loop of Henle relationship: part_of UBERON:0001288 {source="FMA"} ! loop of Henle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001290 +name: proximal straight tubule +is_a: UBERON:0006853 ! renal cortex tubule +is_a: UBERON:0009035 ! renal straight tubule +relationship: continuous_with UBERON:0001287 ! proximal convoluted tubule +relationship: continuous_with UBERON:0005096 ! descending thin limb +relationship: part_of UBERON:0001289 ! descending limb of loop of Henle +relationship: part_of UBERON:0004134 ! proximal tubule +relationship: part_of UBERON:0006542 ! outer medulla outer stripe loop of Henle [Term] id: UBERON:0001291 name: thick ascending limb of loop of Henle namespace: uberon def: "The distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule." [MGI:anna, MP:0011344] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ascending thick limb" EXACT [] @@ -215361,12 +318789,14 @@ is_a: UBERON:0009035 {source="MA"} ! renal straight tubule relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI property_value: editor_note "TODO - thick/thin check. Also - does the loop of Henle overlap the distal convoluted tubule? FMA divides DCT into straight and convoluted portions" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001292 name: distal convoluted tubule namespace: uberon def: "The first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa." [GO:0072025] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "distal convoluted renal tubule" EXACT [] @@ -215385,9 +318815,11 @@ xref: Wikipedia:Distal_convoluted_tubule is_a: UBERON:0006534 {source="MA"} ! renal convoluted tubule is_a: UBERON:0006853 ! renal cortex tubule is_a: UBERON:0012275 ! meso-epithelium +relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule relationship: develops_from UBERON:0003220 ! metanephric mesenchyme relationship: part_of UBERON:0004135 {source="EMAPA", source="GO", source="MA-modified-from-isa"} ! distal tubule -property_value: depicted:by Kidney:nephron.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "a portion of kidney nephron between the loop of Henle and the collecting duct system[Wikipedia:Distal_convoluted_tubule]." xsd:string {source="Wikipedia:Distal_convoluted_tubule"} property_value: UBPROP:0000009 "in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." xsd:string @@ -215412,6 +318844,7 @@ xref: FMA:17733 xref: MA:0001653 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: contributes_to_morphology_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla [Term] @@ -215419,6 +318852,7 @@ id: UBERON:0001294 name: inner medulla of kidney namespace: uberon def: "Innermost region of the mammalian kidney." [GO:0072053] +subset: human_reference_atlas subset: pheno_slim synonym: "inner renal medulla" EXACT [] synonym: "inner zone of medulla of kidney" EXACT [] @@ -215435,7 +318869,10 @@ xref: FMA:17734 xref: MA:0001652 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: contributes_to_morphology_of UBERON:0000362 ! renal medulla +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000362 ! renal medulla +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "unique to mammals" xsd:string {source="GO:0072053"} [Term] @@ -215444,6 +318881,7 @@ name: endometrium namespace: uberon def: "The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy." [MESH:A05.360.319.679.490, MGI:smb, MP:0004896] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "tunica mucosa (endometrium)" EXACT [FMA:17742] @@ -215469,8 +318907,13 @@ xref: VHOG:0001285 xref: Wikipedia:Endometrium is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000995 ! uterus +relationship: contributes_to_morphology_of UBERON:0000995 ! uterus +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000459 {source="FMA"} ! uterine wall -property_value: depicted:by Illu:cervix.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The mucous membrane lining the uterus. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001285", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Endometrium"} property_value: UBPROP:0000003 "The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001285", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "endometrial" xsd:string @@ -215505,8 +318948,11 @@ xref: VHOG:0001281 xref: Wikipedia:Myometrium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034933 ! layer of smooth muscle tissue +relationship: contributes_to_morphology_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000459 {source="FMA"} ! uterine wall -property_value: depicted:by Illu:cervix.jpg xsd:anyURI +relationship: surrounded_by UBERON:0001297 ! serosa of uterus +relationship: surrounds UBERON:0001295 ! endometrium +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg xsd:anyURI property_value: UBPROP:0000001 "The muscular wall of the uterus. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001281", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/myometrium"} property_value: UBPROP:0000003 "In all mammals, the uterus develops as a specialization of the paramesonephric or Müllerian ducts, which gives rise to the infundibula, oviducts, uterus, cervix, and anterior vagina. Morphogenetic events common to development of all uteri include: 1) differentiation and growth of the myometrium, 2) differentiation and morphogenesis of the endometrial glands, and 3) organization and stratification of endometrial stroma. Uterine development is initiated in the fetus, but is only completed postnatally with differentiation and development of the endometrial glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001281", ontology="VHOG", source="PMID:15471813 Spencer TE, Bazer FW, Uterine and placental factors regulating conceptus growth in domestic animals. Journal of Animal Science (2004)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "myometrial" xsd:string @@ -215535,8 +318981,10 @@ xref: UMLS:C0227824 {source="ncithesaurus:Perimetrium"} xref: Wikipedia:Perimetrium is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000459 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! uterine wall -property_value: depicted:by Illu:cervix.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg xsd:anyURI property_value: editor_note "TODO - check for parallel structure with peritoneum" xsd:string [Term] @@ -215562,10 +319010,14 @@ xref: UMLS:C0227948 {source="ncithesaurus:Glans_Penis"} xref: VHOG:0001475 xref: Wikipedia:Glans_penis is_a: UBERON:0035651 ! glans +intersection_of: UBERON:0035651 ! glans +intersection_of: part_of UBERON:0000989 ! penis +relationship: contributes_to_morphology_of UBERON:0000989 ! penis relationship: immediate_transformation_of UBERON:0013239 {source="Bgee:AN"} ! future glans penis relationship: part_of UBERON:0000989 ! penis +relationship: sexually_homologous_to UBERON:0006653 ! glans clitoris property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg xsd:anyURI -property_value: depicted:by Male:anatomy.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png xsd:anyURI [Term] id: UBERON:0001300 @@ -215591,6 +319043,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034929 ! external soft tissue zone relationship: develops_from UBERON:0011756 {source="Wikipedia"} ! male genital swelling +relationship: only_in_taxon NCBITaxon:32525 ! Theria relationship: part_of UBERON:0004053 ! external male genitalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a6/Scrotum_warm_and_cold.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/en/thumb/3/3e/HairedHumanScrotum.png/200px-HairedHumanScrotum.png xsd:anyURI @@ -215620,7 +319073,7 @@ xref: GAID:397 xref: galen:Epididymis xref: MA:0000397 xref: MAT:0000130 -xref: MESH:A05.360.444.849.286 +xref: MESH:D004822 xref: MIAA:0000130 xref: NCIT:C12328 xref: SCTID:181432000 @@ -215630,7 +319083,12 @@ xref: Wikipedia:Epididymis is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system +relationship: channel_for CL:0000019 ! sperm +relationship: channels_from UBERON:0006946 ! efferent duct +relationship: channels_into UBERON:0001000 ! vas deferens +relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia relationship: develops_from UBERON:0003074 {source="Wikipedia"} ! mesonephric duct +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0006947 {source="FMA"} ! male genital duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_testis_surface.jpg xsd:anyURI property_value: editor_note "Kardong has epididymis in elasmobranch" xsd:string @@ -215638,11 +319096,60 @@ property_value: UBPROP:0000007 "epididymal" xsd:string property_value: UBPROP:0000008 "A similar, but probably non-homologous, structure is found in cartilaginous fishes" xsd:string {source="WP"} property_value: UBPROP:0000010 "Typically divided into three main regions. In reptiles, there is an additional canal between the testis and the head of the epididymis, which receives the various efferent ducts. This is, however, absent in all birds and mammals. The epididymis is covered by a two layered pseudostratified epithelium. The epithelium is separated by a basement membrane from the connective tissue wall which has smooth muscle cells." xsd:string +[Term] +id: UBERON:0001302 +name: right uterine tube +namespace: uberon +def: "A fallopian tube that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] +synonym: "right fallopian tube" EXACT [] +synonym: "right oviduct" EXACT [] +xref: EMAPA:37369 {source="MA:th"} +xref: FMA:18483 +xref: MA:0001717 +xref: NCIT:C33475 +xref: SCTID:280106006 +xref: UMLS:C0227900 {source="ncithesaurus:Right_Fallopian_Tube"} +is_a: UBERON:0003889 ! fallopian tube +intersection_of: UBERON:0003889 ! fallopian tube +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI +property_value: UBPROP:0000008 "non-functional in monotremes[ISBN:978-0226870137]" xsd:string + +[Term] +id: UBERON:0001303 +name: left uterine tube +namespace: uberon +def: "A fallopian tube that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] +synonym: "left fallopian tube" EXACT [] +synonym: "left oviduct" EXACT [] +xref: EMAPA:37368 {source="MA:th"} +xref: FMA:18484 +xref: MA:0001716 +xref: NCIT:C32959 +xref: SCTID:280107002 +xref: UMLS:C0227902 {source="ncithesaurus:Left_Fallopian_Tube"} +is_a: UBERON:0003889 ! fallopian tube +intersection_of: UBERON:0003889 ! fallopian tube +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI + +[Term] +id: UBERON:0001304 +name: germinal epithelium of ovary +is_a: UBERON:0000484 ! simple cuboidal epithelium +is_a: UBERON:0004911 ! epithelium of female gonad +intersection_of: UBERON:0000484 ! simple cuboidal epithelium +intersection_of: part_of UBERON:0001307 ! capsule of ovary +relationship: part_of UBERON:0001307 ! capsule of ovary + [Term] id: UBERON:0001305 name: ovarian follicle namespace: uberon def: "A spherical aggregation of cells in the ovary that contains a single oocyte[WP,modified]." [http://www.repropedia.org/ovarian-follicle, Wikipedia:Ovarian_follicle] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -215667,14 +319174,16 @@ xref: UMLS:C0018120 {source="ncithesaurus:Ovarian_Follicle"} xref: VHOG:0001536 xref: Wikipedia:Ovarian_follicle xref: ZFA:0001110 -is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure -is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:8450001 ! egg follicle relationship: develops_from UBERON:0005296 {source="Wikipedia"} ! ovary sex cord -relationship: part_of UBERON:0000992 ! ovary +relationship: has_part CL:0000023 ! oocyte +relationship: has_part CL:0002174 ! follicular cell of ovary +relationship: has_part UBERON:0000038 ! follicular fluid property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ca/Human_ovarian_follicle.jpg xsd:anyURI -property_value: depicted:by Primary:follicle-4.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG xsd:anyURI property_value: editor_note "TODO - align subtypes based on staging, which is taxon-specific" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Oocyte development of zebrafish has been divided into five stages based on morphological criteria and on physiological and biochemical events. Stage I follicles (less than 140 microns) are primary growth stage, stage II follicles (140-340 microns) are cortical alveolus stage, stage III (340-690 microns) are vitellogenesis, stage IV (690-730 microns) are oocyte maturation, and stage V follicles are matured egg. Selman et al, 1993.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001110", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001536", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. These eggs/ova are only developed once every menstrual cycle (e.g. once a month in humans)" xsd:string @@ -215694,14 +319203,31 @@ xref: MA:0001706 xref: NCIT:C49265 xref: SCTID:258491008 xref: UMLS:C0227877 {source="ncithesaurus:Ovarian_Capsule"} +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003893 ! capsule is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0000992 ! ovary +relationship: bounding_layer_of UBERON:0000992 ! ovary + +[Term] +id: UBERON:0001308 +name: external iliac artery +is_a: UBERON:0005609 ! iliac artery +relationship: part_of UBERON:0001191 ! common iliac artery + +[Term] +id: UBERON:0001309 +name: internal iliac artery +is_a: UBERON:0005609 ! iliac artery +relationship: part_of UBERON:0001191 ! common iliac artery [Term] id: UBERON:0001310 name: umbilical artery namespace: uberon def: "The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]." [https://github.com/obophenotype/uberon/issues/328, Wikipedia:Umbilical_artery] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "a. umbilicalis" RELATED LATIN [Wikipedia:Umbilical_artery] @@ -215725,8 +319251,30 @@ is_a: UBERON:0001637 ! artery is_a: UBERON:0010260 ! umbilical blood vessel property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png xsd:anyURI property_value: editor_note "todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/328 xsd:anyURI +[Term] +id: UBERON:0001311 +name: inferior vesical artery +is_a: UBERON:0004573 ! systemic artery +is_a: UBERON:0009027 ! vesical artery +intersection_of: UBERON:0009027 ! vesical artery +intersection_of: supplies UBERON:0006082 ! fundus of urinary bladder +relationship: branching_part_of UBERON:0001309 ! internal iliac artery +relationship: supplies UBERON:0000998 {gci_filler="UBERON:0003101", gci_relation="part_of"} ! seminal vesicle +relationship: supplies UBERON:0001000 {gci_filler="UBERON:0003101", gci_relation="part_of"} ! vas deferens +relationship: supplies UBERON:0002367 {gci_filler="UBERON:0003101", gci_relation="part_of"} ! prostate gland +relationship: supplies UBERON:0006082 ! fundus of urinary bladder + +[Term] +id: UBERON:0001312 +name: superior vesical artery +is_a: UBERON:0003468 ! ureteric segment of renal artery +is_a: UBERON:0009027 ! vesical artery +intersection_of: UBERON:0009027 ! vesical artery +intersection_of: supplies UBERON:0000056 ! ureter + [Term] id: UBERON:0001317 name: internal iliac vein @@ -215752,12 +319300,31 @@ is_a: UBERON:0005610 {source="MA"} ! iliac vein relationship: drains UBERON:0005179 ! pelvic region element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cb/Internaliliacv.png xsd:anyURI +[Term] +id: UBERON:0001318 +name: inferior vesical vein +is_a: UBERON:0002460 ! vesical vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0006082 ! fundus of urinary bladder +relationship: drains UBERON:0006082 ! fundus of urinary bladder + +[Term] +id: UBERON:0001319 +name: vaginal vein +is_a: UBERON:0001638 ! vein +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina +relationship: tributary_of UBERON:0001317 ! internal iliac vein + [Term] id: UBERON:0001322 name: sciatic nerve namespace: uberon def: "A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb." [Wikipedia:Sciatic_nerve] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "ischiadic nerve" RELATED [Wikipedia:Sciatic_nerve] @@ -215783,11 +319350,21 @@ xref: UMLS:C0036394 {source="BIRNLEX:1133"} xref: UMLS:C0036394 {source="ncithesaurus:Sciatic_Nerve"} xref: VHOG:0000894 xref: Wikipedia:Sciatic_nerve +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001021 ! nerve +relationship: innervates UBERON:0001511 ! skin of leg +relationship: overlaps UBERON:0000978 ! leg relationship: part_of UBERON:0001815 ! lumbosacral nerve plexus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "mouse sciatic nerve origins predominantly from the third lumbar (L3) and L4 spinal nerves, unlike the L4 and L5 in rats - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700063/" xsd:string +[Term] +id: UBERON:0001323 +name: tibial nerve +is_a: UBERON:0003431 ! leg nerve +relationship: branching_part_of UBERON:0001322 ! sciatic nerve + [Term] id: UBERON:0001324 name: common fibular nerve @@ -215815,6 +319392,7 @@ xref: UMLS:C0031173 {source="ncithesaurus:Peroneal_Nerve"} xref: Wikipedia:Common_fibular_nerve is_a: UBERON:0003431 ! leg nerve is_a: UBERON:0035652 ! fibular nerve +relationship: branching_part_of UBERON:0001322 ! sciatic nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9d/Gray832.png xsd:anyURI property_value: UBPROP:0000010 "derives into deep and superficial branches" xsd:string @@ -215835,6 +319413,8 @@ xref: FMA:19086 xref: MA:0000534 is_a: UBERON:0003833 {source="MA"} ! abdominal segment muscle is_a: UBERON:0005179 ! pelvic region element +intersection_of: UBERON:0014892 {source="FMAdef"} ! skeletal muscle organ +intersection_of: part_of UBERON:0002355 {source="FMAdef"} ! pelvic region of trunk [Term] id: UBERON:0001328 @@ -215854,6 +319434,8 @@ xref: UMLS:C0227970 {source="ncithesaurus:Prostate_Gland_Lobe"} is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0009912 ! anatomical lobe +intersection_of: UBERON:0009912 ! anatomical lobe +intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland property_value: UBPROP:0000008 "Anatomically, the human prostate gland is located between the base of the bladder and the rectum, and it completely surrounds the proximal urethra (Fig. 1A). It is a single alobular structure with central (CZ), peripheral (PZ) and transitional (TZ) zones. In contrast, the mouse prostate is not merged into one compact anatomical structure. It comprises four paired lobes situated circumferentially around the urethra, immediately caudal to the urinary bladder-namely, anterior (AP), dorsal (DP), lateral (LP), and ventral (VP) prostate (Fig. 1B). Often, the dorsal and the lateral lobes are thought of in combination and referred to as the dorsolateral (DLP) lobe as they share a ductal system. The mouse AP is considered analogous to the human CZ, which is rarely a site of neoplastic transformation in humans. The mouse DLP is considered most similar to the human PZ, which is the zone in which most carcinomas arise (Xue et al. 1997). These analogies, however, are limited as they are based solely on descriptive data and need to be re-evaluated using molecular techniques before the relationship between specific mouse prostate lobes and the human prostate zones is definitively asserted (Abate-Shen & Shen 2000). The mouse VP does not have a human homologue, and the human TZ does not have a murine homologue" xsd:string {source="PMID:15163300", source="https://github.com/obophenotype/uberon/issues/665"} @@ -215882,6 +319464,12 @@ is_a: UBERON:0001328 ! lobe of prostate property_value: editor_note "consider splitting and having distinct classes for mouse coagulating gland and human anterior prostate. See https://github.com/obophenotype/uberon/issues/665" xsd:string property_value: editor_note "TODO - check - see comments from http://www.ncbi.nlm.nih.gov/pubmed/15163300" xsd:string +[Term] +id: UBERON:0001330 +name: pampiniform plexus +is_a: UBERON:0001593 ! venous plexus +relationship: located_in UBERON:0005352 ! spermatic cord + [Term] id: UBERON:0001331 name: skin of penis @@ -215898,6 +319486,9 @@ xref: SCTID:35900000 is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0000989 ! penis +relationship: continuous_with UBERON:0001085 ! skin of trunk relationship: part_of UBERON:0000989 ! penis [Term] @@ -215929,10 +319520,13 @@ xref: SCTID:181426005 xref: UMLS:C0227952 {source="ncithesaurus:Male_Prepuce"} xref: Wikipedia:Foreskin is_a: UBERON:0011374 ! prepuce +intersection_of: UBERON:0011374 ! prepuce +intersection_of: part_of UBERON:0000989 ! penis +relationship: adjacent_to UBERON:0001299 ! glans penis relationship: part_of UBERON:0000989 ! penis relationship: transformation_of UBERON:0035005 ! preputial swelling of male -property_value: depicted:by Foreskin:CloseupV2.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg xsd:anyURI [Term] id: UBERON:0001333 @@ -215950,8 +319544,10 @@ xref: SCTID:264085007 xref: UMLS:C0458452 {source="ncithesaurus:Male_Urethra"} xref: Wikipedia:Male_urethra is_a: UBERON:0000057 ! urethra +intersection_of: UBERON:0000057 ! urethra +intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0003101 ! male organism -property_value: depicted:by Female:anatomy.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI [Term] id: UBERON:0001334 @@ -215971,14 +319567,17 @@ xref: SCTID:264469008 xref: UMLS:C0458485 {source="ncithesaurus:Female_Urethra"} xref: Wikipedia:Female_urethra is_a: UBERON:0000057 ! urethra +intersection_of: UBERON:0000057 ! urethra +intersection_of: part_of UBERON:0003100 ! female organism relationship: part_of UBERON:0003100 ! female organism -property_value: depicted:by Female:anatomy.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png xsd:anyURI [Term] id: UBERON:0001335 name: prostatic urethra namespace: uberon def: "The widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum)." [MGI:anna, MP:0011777] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "male prostatic urethra" EXACT [MP:0011777] @@ -215997,8 +319596,11 @@ xref: UMLS:C0458450 {source="ncithesaurus:Prostatic_Portion_of_the_Male_Urethra" xref: Wikipedia:Prostatic_urethra is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube +relationship: contributes_to_morphology_of UBERON:0001333 ! male urethra +relationship: located_in UBERON:0002367 ! prostate gland relationship: part_of UBERON:0001333 {source="FMA", source="MA"} ! male urethra property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray1142.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001336 @@ -216070,6 +319672,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000057 ! urethra relationship: contributes_to_morphology_of UBERON:0000057 ! urethra +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000057 ! urethra property_value: UBPROP:0000012 "NCIT:C12339 paraurethral gland belongs here" xsd:string {external_ontology="NCIT"} @@ -216109,6 +319712,10 @@ xref: XAO:0003088 is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system +relationship: channel_for CL:0000019 ! sperm +relationship: channels_into UBERON:0003959 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! rete testis +relationship: contains_process GO:0007283 ! spermatogenesis +relationship: contains_process GO:0051321 ! meiotic cell cycle relationship: develops_from UBERON:0005297 {source="Wikipedia"} ! testis sex cord relationship: part_of UBERON:0000473 ! testis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/49/Seminiferous_tubule_and_sperm_low_mag.jpg xsd:anyURI @@ -216137,6 +319744,9 @@ xref: NCIT:C49313 xref: UMLS:C0920840 {source="ncithesaurus:Vaginal_Epithelium"} is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0004804 ! oviduct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000996 ! vagina +relationship: contributes_to_morphology_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina property_value: UBPROP:0000012 "FMA: nonkeratinizing stratified squamous epithelium; BTO: Vaginal epithelium is stratified squamous epithelium having a thickness of 15-200 microns; MA has single subclass (squamous)" xsd:string {external_ontology="FMA"} @@ -216185,6 +319795,7 @@ xref: EMAPA:35926 xref: FMA:20117 xref: MA:0000058 xref: MAT:0000199 +xref: MESH:D052436 xref: MIAA:0000199 xref: NCIT:C33889 xref: UMLS:C1704223 {source="ncithesaurus:White_Adipose_Tissue"} @@ -216221,7 +319832,7 @@ xref: SCTID:15965003 xref: UMLS:C0006298 {source="ncithesaurus:Brown_Adipose_Tissue"} xref: Wikipedia:Brown_adipose_tissue is_a: UBERON:0001013 ! adipose tissue -property_value: depicted:by Brownfat:PETCT.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/69/Brownfat_PETCT.jpg xsd:anyURI property_value: UBPROP:0000001 "Adipose tissue, cells of which contain multiple small lipid droplets.[FMA]" xsd:string {source="FMA"} property_value: UBPROP:0000008 "especially abundant in newborns and in hibernating mammals" xsd:string property_value: UBPROP:0000009 "thermogenesis" xsd:string @@ -216267,8 +319878,12 @@ xref: Wikipedia:Coccyx is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0006076 ! caudal region of vertebral column is_a: UBERON:0008001 {source="FMA"} ! irregular bone +intersection_of: UBERON:0006076 ! caudal region of vertebral column +intersection_of: part_of UBERON:0001270 ! bony pelvis +intersection_of: RO:0002374 UBERON:0001095 ! derived from ancestral fusion of caudal vertebra relationship: develops_from UBERON:0007144 ! embryonic post-anal tail relationship: part_of UBERON:0001270 {source="FMA"} ! bony pelvis +relationship: RO:0002374 UBERON:0001095 ! derived from ancestral fusion of caudal vertebra property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/91/Gray100.png xsd:anyURI property_value: UBPROP:0000001 "Small, bony element consisting of several fused, rudimentary caudal vertebrae; near metamorphosis the hypochord fuses to the coccyx, thereby forming the urostyle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000731", ontology="AAO", source="AAO:Pugener_2002", source="AAO:Pugener_and_Maglia_2008"} property_value: UBPROP:0000007 "coccygeal" xsd:string @@ -216328,8 +319943,10 @@ xref: Wikipedia:External_acoustic_meatus is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: capable_of_part_of GO:0055127 ! vibrational conductance of sound to the inner ear relationship: develops_from UBERON:0005872 {source="PMID:11237469"} ! 1st arch pharyngeal cleft relationship: part_of UBERON:0001691 {source="FMA"} ! external ear +relationship: surrounded_by UBERON:0010065 ! auditory meatus epithelium property_value: editor_note "consider revisiting superclass after refinement of CARO/EAO, conduit may not be quite correct." xsd:string property_value: UBPROP:0000011 "tympanic ring, which serves as support for the tympanic membrane, directs invagination of the first pharingeal cleft ectoderm to form the external acoustic meatus (EAM), which provides the outer layer of the membrane[PMID 11237469]" xsd:string property_value: UBPROP:0000012 "subdivision of head in FMA." xsd:string {external_ontology="FMA"} @@ -216361,11 +319978,31 @@ xref: VHOG:0000395 xref: WBbt:0006919 is_a: UBERON:0000475 ! organism subdivision relationship: has_developmental_contribution_from UBERON:0000931 {evidence="cjm"} ! proctodeum +relationship: overlaps UBERON:0006866 ! terminal part of digestive tract property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/507 xsd:anyURI property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000395", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000395", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11"} +[Term] +id: UBERON:0001355 +name: deep femoral artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0002060 ! femoral artery +intersection_of: part_of UBERON:0035551 ! deep vasculature +relationship: branching_part_of UBERON:0002060 ! femoral artery +relationship: part_of UBERON:0035551 ! deep vasculature + +[Term] +id: UBERON:0001356 +name: medial circumflex femoral artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0007119 ! neck of femur +relationship: branching_part_of UBERON:0001355 ! deep femoral artery +relationship: supplies UBERON:0007119 ! neck of femur + [Term] id: UBERON:0001359 name: cerebrospinal fluid @@ -216390,7 +320027,7 @@ xref: FMA:20935 xref: GAID:1181 xref: MA:0002503 xref: MAT:0000499 -xref: MESH:A12.207.268 +xref: MESH:D002555 xref: NCIT:C12692 xref: TAO:0002184 xref: UMLS:C0007806 {source="BIRNLEX:1798"} @@ -216400,6 +320037,8 @@ xref: Wikipedia:Cerebrospinal_fluid xref: ZFA:0001626 is_a: UBERON:0007779 {source="Wikipedia"} ! transudate relationship: develops_from UBERON:0002307 {notes="see notes", source="EHDAA2"} ! choroid plexus of lateral ventricle +relationship: filtered_through UBERON:0001886 ! choroid plexus +relationship: located_in UBERON:0005281 ! ventricular system of central nervous system property_value: editor_note "many sources state the CP as sole producer of CSF, but this is disputed [DOI:10.1007/s11064-015-1581-6]" xsd:string property_value: UBPROP:0000001 "Portion of organism substance that is a clear fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002184", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "In vertebrates, at early stages of Central Nervous System (CNS) development, the architecture of the brain primordium reveals the presence of the cavity of brain vesicles, which is filled by Embryonic Cerebro-Spinal Fluid (E-CSF). (...) Rat and chick E-CSF proteomes are similar, although rat is more complex in certain groups of proteins, e.g., apolipoproteins, which may be involved in the control of neural diversity, and has soluble enzymes present, just like adult human CSF, but unlike chick E-CSF, revealing phylogenetic brain differences between these groups of vertebrates.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001278", ontology="VHOG", source="DOI:10.1021/pr050213t Parada C, Gato A, Bueno D, Mammalian embryonic cerebrospinal fluid proteome has greater apolipoprotein and enzyme pattern complexity than the avian proteome. Journal of Proteome Research (2005)", source="http://bgee.unil.ch/"} @@ -216426,6 +320065,12 @@ xref: UMLS:C0036036 {source="ncithesaurus:Sacroiliac_Joint"} xref: Wikipedia:Sacroiliac_joint is_a: UBERON:0011107 {source="FMA"} ! synovial joint of pelvic girdle is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001273 ! ilium +intersection_of: connects UBERON:0003690 ! fused sacrum +relationship: connects UBERON:0001273 ! ilium +relationship: connects UBERON:0003690 ! fused sacrum +relationship: in_lateral_side_of UBERON:0002355 ! pelvic region of trunk relationship: part_of UBERON:0001270 ! bony pelvis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray319.png xsd:anyURI property_value: UBPROP:0000008 "In humans, the sacrum supports the spine and is supported in turn by an ilium on each side" xsd:string @@ -216448,6 +320093,7 @@ xref: TAO:0005131 xref: VHOG:0001527 xref: Wikipedia:Parietal_peritoneum xref: ZFA:0005131 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: part_of UBERON:0002358 ! peritoneum @@ -216461,6 +320107,8 @@ id: UBERON:0001367 name: external anal sphincter namespace: uberon def: "The Sphincter ani externus (external anal sphincter) is a flat plane of muscular fibers, elliptical in shape and intimately adherent to the integument surrounding the margin of the anus. [WP,unvetted]." [Wikipedia:Sphincter_ani_externus_muscle] +comment: Some literature reports don't consider the external anal sphincter to be a true sphincter muscle. +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "external sphincter ani" EXACT [] @@ -216474,9 +320122,13 @@ xref: SCTID:244969008 xref: UMLS:C0224395 {source="ncithesaurus:External_Anal_Sphincter"} xref: Wikipedia:Sphincter_ani_externus_muscle is_a: UBERON:0003898 ! skeletal muscle tissue of trunk +is_a: UBERON:0004519 ! muscle of anal triangle is_a: UBERON:0004832 {source="MA"} ! anal region skeletal muscle -relationship: part_of UBERON:0006867 {source="FMA"} ! anal part of perineum +is_a: UBERON:0004916 ! anal sphincter +is_a: UBERON:0007522 ! striated muscle sphincter property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 +property_value: seeAlso https://github.com/obophenotype/uberon/issues/2344 xsd:string [Term] id: UBERON:0001371 @@ -216572,7 +320224,7 @@ xref: NCIT:C52987 xref: UMLS:C0224452 {source="ncithesaurus:Semimembranosus"} xref: Wikipedia:Semimembranosus is_a: UBERON:0002463 {source="cjm"} ! muscle of posterior compartment of hindlimb stylopod -property_value: depicted:by Semimembranosus:muscle.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/bf/Semimembranosus_muscle.PNG xsd:anyURI [Term] id: UBERON:0001383 @@ -216600,6 +320252,8 @@ xref: MA:0000672 xref: RETIRED_EHDAA2:0000974 xref: Wikipedia:Leg_muscle is_a: UBERON:0003663 ! hindlimb muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0000978 ! leg relationship: part_of UBERON:0004466 {source="prolog"} ! musculature of leg property_value: UBPROP:0000013 "see notes on UBERON:0000978 for possible confusion over the term 'leg'." xsd:string @@ -216609,6 +320263,7 @@ name: primary motor cortex namespace: uberon def: "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html." [NLX:143555] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "excitable area" RELATED [BTO:0004348] @@ -216629,20 +320284,23 @@ xref: DHBA:10162 xref: EFO:0002472 xref: EMAPA:35704 xref: FMA:224854 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1910 xref: MA:0000907 xref: MBA:985 -xref: MESH:A08.186.211.730.885.213.270.548 +xref: MESH:D009044 xref: NCIT:C97339 +xref: neuronames:1910 xref: NLX:143555 xref: SCTID:11931008 xref: UMLS:C0026607 {source="ncithesaurus:Primary_Motor_Cortex"} xref: Wikipedia:Primary_motor_cortex is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0000956 ! cerebral cortex +relationship: contributes_to_morphology_of UBERON:0001870 ! frontal cortex relationship: part_of UBERON:0001870 {source="MA", source="Wikipedia"} ! frontal cortex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png xsd:anyURI property_value: editor_note "TODO - in MA this is asserted to be part_of BOTH frontal and parietal cortex. in ABA these are disjoint. FMA makes no commitment beyond cerebral cortex. Wikipedia says frontal lobe. Check if species difference or difference in definition. Removed relationship: part_of UBERON:0001872 parietal lobe" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP]" xsd:string {date_retrieved="2012-08-31", external_class="MP:0000800", ontology="MP", source="MGI:csmith"} property_value: UBPROP:0000001 "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html" xsd:string {source="NLX:143555"} @@ -216781,11 +320439,11 @@ xref: BTO:0004343 xref: EMAPA:35156 xref: FMA:226221 xref: GAID:682 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1556 xref: MA:0000942 xref: MBA:247 -xref: MESH:A08.186.211.730.885.213.863.297 +xref: MESH:D001303 xref: NCIT:C52712 +xref: neuronames:1556 xref: UMLS:C0004302 {source="ncithesaurus:Auditory_Cortex"} xref: Wikipedia:Auditory_cortex is_a: UBERON:0002616 ! regional part of brain @@ -216794,6 +320452,15 @@ relationship: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0001871 {source="MA"} ! temporal lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/81/Brodmann_41_42.png xsd:anyURI +[Term] +id: UBERON:0001394 +name: axillary artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0009472 ! axilla +relationship: part_of UBERON:0001467 ! shoulder +relationship: supplies UBERON:0009472 ! axilla + [Term] id: UBERON:0001401 name: longissimus thoracis muscle @@ -216966,6 +320633,15 @@ property_value: UBPROP:0000001 "An organism subdivision that includes the pector property_value: UBPROP:0000001 "An organism subdivision that includes the pectoral girdle skeleton. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There is only one instance of the pectoral girdle region per organism.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000305", ontology="VSAO", source="https://orcid.org/0000-0002-6601-2165"} property_value: UBPROP:0000005 "Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO]" xsd:string {date_retrieved="2012-09-06", external_class="VSAO:0000305", ontology="VSAO", source="Curator"} +[Term] +id: UBERON:0001422 +name: facial lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0001456 ! face +relationship: part_of UBERON:0001456 ! face +relationship: part_of UBERON:0011363 ! cranial lymph vasculature + [Term] id: UBERON:0001423 name: radius bone @@ -216982,7 +320658,7 @@ xref: FMA:23463 xref: GAID:185 xref: galen:Radius xref: MA:0001357 -xref: MESH:A02.835.232.087.702 +xref: MESH:D011884 xref: NCIT:C12777 xref: OpenCyc:Mx4rwUsDcZwpEbGdrcN5Y29ycA xref: SCTID:181940002 @@ -216992,6 +320668,9 @@ xref: Wikipedia:Radius_(bone) is_a: UBERON:0003466 ! forelimb zeugopod bone is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0015001 ! radius endochondral element +intersection_of: UBERON:0015001 ! radius endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: BSPO:0001113 UBERON:0010703 ! forelimb zeugopod skeleton relationship: develops_from UBERON:0006286 {evidence="definitional"} ! radius cartilage element property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the lateral side of the ulna. Its upper end articulates with both the humerus and the ulna, whereas the lower articulates with the carpals.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000788", ontology="AAO", source="AAO:LAP"} @@ -217009,7 +320688,7 @@ xref: FMA:23466 xref: GAID:188 xref: galen:Ulna xref: MA:0001358 -xref: MESH:A02.835.232.087.911 +xref: MESH:D014457 xref: NCIT:C12809 xref: OpenCyc:Mx4rwPtIM5wpEbGdrcN5Y29ycA xref: SCTID:181948009 @@ -217019,11 +320698,22 @@ xref: Wikipedia:Ulna is_a: UBERON:0003466 ! forelimb zeugopod bone is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0015003 ! ulna endochondral element +intersection_of: UBERON:0015003 ! ulna endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: BSPO:0001115 UBERON:0010703 ! forelimb zeugopod skeleton relationship: develops_from UBERON:0006306 {evidence="definitional"} ! ulna cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg xsd:anyURI property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the fore-epipodium; it is located on the medial (inner) side of the radius. The upper end of the ulna articulates with the lower end of the humerus forming a strong hinge joint with the carpals, whereas the lower articulates with the carpals.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000789", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000007 "ulnar" xsd:string +[Term] +id: UBERON:0001425 +name: pectoral lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0001421 ! pectoral girdle region +relationship: part_of UBERON:0001421 ! pectoral girdle region + [Term] id: UBERON:0001427 name: radiale @@ -217048,7 +320738,7 @@ xref: FMA:23709 xref: GAID:180 xref: galen:Scaphoid xref: MA:0002555 -xref: MESH:A02.835.232.087.144.650 +xref: MESH:D021361 xref: NCIT:C12854 xref: OpenCyc:Mx4rwAwWe5wpEbGdrcN5Y29ycA xref: SCTID:181958008 @@ -217084,7 +320774,7 @@ xref: FMA:23712 xref: GAID:181 xref: galen:Lunate xref: MA:0002556 -xref: MESH:A02.835.232.087.144.663 +xref: MESH:D012667 xref: NCIT:C12786 xref: SCTID:181959000 xref: UMLS:C0036624 {source="ncithesaurus:Lunate_Bone"} @@ -217262,17 +320952,18 @@ xref: VHOG:0001254 xref: VSAO:0000027 xref: XAO:0003060 xref: ZFA:0000434 -is_a: BFO:0000040 ! material entity is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: has_part UBERON:0004288 ! skeleton intersection_of: has_part UBERON:0004770 ! articular system disjoint_from: UBERON:0001474 ! bone element disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0004288 ! skeleton @@ -217304,7 +320995,7 @@ xref: FMA:23889 xref: GAID:179 xref: galen:CarpalBone xref: MA:0000296 -xref: MESH:A02.835.232.087.144 +xref: MESH:D002348 xref: NCIT:C12688 xref: SCTID:83936004 xref: UMLS:C0007285 {source="ncithesaurus:Carpal_Bone"} @@ -217312,6 +321003,9 @@ xref: Wikipedia:Carpus is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0005897 ! manus bone is_a: UBERON:0015049 ! carpus endochondral element +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0004452 ! carpal region +disjoint_from: UBERON:0012358 ! manual digitopodium bone relationship: develops_from UBERON:0006213 ! carpus cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg xsd:anyURI property_value: UBPROP:0000008 "In tetrapods, the carpals is the sole cluster of the bones in the wrist between the radius and ulna and the metacarpus. The bones of the carpus do not belong to individual fingers (or toes in quadrupeds), whereas those of the metacarpus do. The corresponding part of the foot is the tarsus. The carpal bones allow the wrist to move and rotate vertically, horizontally and laterally. In human anatomy, the main role of the carpus is to facilitate effective positioning of the hand and powerful use of the extensors and flexors of the forearm, but the mobility of individual carpal bones increase the freedom of movements at the wrist." xsd:string {source="Wikipedia:Carpus"} @@ -217351,6 +321045,8 @@ is_a: UBERON:0003221 ! phalanx is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0004249 ! manual digit bone is_a: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0002389 ! manual digit relationship: develops_from UBERON:0010686 ! manual digit phalanx cartilage element property_value: UBPROP:0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the four digits of the manus. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the manus, in a medial to lateral sequence, is 2-2-3-3.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000947", ontology="AAO", source="AAO:LAP"} @@ -217359,6 +321055,7 @@ id: UBERON:0001437 name: epiphysis namespace: uberon def: "The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified]." [http://orcid.org/0000-0002-6601-2165, MESH:A02.835.232.251] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bone epiphysis" EXACT [] @@ -217377,7 +321074,9 @@ xref: SCTID:244701002 xref: UMLS:C1708734 {source="ncithesaurus:Long_Bone_Epiphysis"} xref: Wikipedia:Epiphysis is_a: UBERON:0005055 ! zone of long bone +relationship: contributes_to_morphology_of UBERON:0002495 ! long bone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso UBERON:0006776 property_value: UBPROP:0000001 "Cartilaginous expansion at the distal end of an anterior rib or transverse process that serves for the attachment of muscles suspending the pectoral girdle to the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000742", ontology="AAO", source="AAO:Pugener_2002"} property_value: UBPROP:0000001 "Subdivision of long bone which forms its expanded proximal or distal articular end; together with other the subdivisions of long bone, it constitutes the long bone. Examples: proximal epiphysis of humerus, distal epiphysis of femur." xsd:string {source="FMA:24012"} @@ -217402,6 +321101,8 @@ xref: SCTID:304581004 xref: UMLS:C0222671 {source="ncithesaurus:Metaphysis"} xref: Wikipedia:Metaphysis is_a: UBERON:0005055 ! zone of long bone +relationship: adjacent_to UBERON:0006861 ! diaphysis proper +relationship: contributes_to_morphology_of UBERON:0002495 ! long bone relationship: part_of UBERON:0004769 ! diaphysis property_value: editor_note "todo - decide - adjacent to or containing epiphyseal plate? AO Notes: FMA the metaphysis is part of the diaphysis, but not in MA." xsd:string property_value: UBPROP:0000001 "Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA]" xsd:string {source="FMA:24014"} @@ -217539,8 +321240,11 @@ xref: FMA:24159 xref: OpenCyc:Mx4rvdHPJJwpEbGdrcN5Y29ycA xref: VSAO:0005020 is_a: UBERON:0006717 ! autopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002398 ! manus relationship: part_of UBERON:0001440 {source="EHDAA2"} ! forelimb skeleton relationship: part_of UBERON:0002398 ! manus +relationship: skeleton_of UBERON:0002398 ! manus property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI [Term] @@ -217569,7 +321273,7 @@ xref: galen:Chest xref: galen:Thorax xref: MA:0000031 xref: MAT:0000295 -xref: MESH:A01.911 +xref: MESH:D013909 xref: MIAA:0000295 xref: NCIT:C12799 xref: NCIT:C25389 @@ -217620,8 +321324,11 @@ xref: EHDAA2:0002228 xref: FMA:24222 xref: VSAO:0005021 is_a: UBERON:0006717 ! autopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002387 ! pes relationship: part_of UBERON:0001441 {source="EHDAA2"} ! hindlimb skeleton relationship: part_of UBERON:0002387 ! pes +relationship: skeleton_of UBERON:0002387 ! pes property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI [Term] @@ -217641,7 +321348,7 @@ xref: FMA:24479 xref: GAID:202 xref: galen:Fibula xref: MA:0001360 -xref: MESH:A02.835.232.500.321 +xref: MESH:D005360 xref: NCIT:C12718 xref: SCTID:302529003 xref: UMLS:C0016068 {source="ncithesaurus:Fibula"} @@ -217649,6 +321356,9 @@ xref: Wikipedia:Fibula is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004251 ! hindlimb zeugopod bone is_a: UBERON:0015013 ! fibula endochondral element +intersection_of: UBERON:0015013 ! fibula endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: BSPO:0001115 UBERON:0010720 ! hindlimb zeugopod skeleton relationship: develops_from UBERON:0010851 ! fibula cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/16/Illu_lower_extremity.jpg xsd:anyURI property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a rather more slender bone than the tibia but of about the same length.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000891", ontology="AAO", source="AAO:LAP"} @@ -217677,15 +321387,18 @@ xref: FMA:24491 xref: GAID:194 xref: galen:TarsalBone xref: MA:0000297 -xref: MESH:A02.835.232.300.710 +xref: MESH:D013639 xref: NCIT:C12796 xref: SCTID:108372004 xref: UMLS:C0039316 {source="ncithesaurus:Tarsal_Bone"} is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0005899 ! pes bone is_a: UBERON:0015050 ! tarsus endochondral element +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0004454 ! tarsal region +disjoint_from: UBERON:0012359 ! pedal digitopodium bone relationship: develops_from UBERON:0010541 ! tarsus cartilage element -property_value: depicted:by Ankle:en.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg xsd:anyURI property_value: UBPROP:0000008 "In primitive tetrapods, such as Trematops, the tarsus consists of three rows of bones. There are three proximal tarsals, the tibiale, intermedium, and fibulare, named for their points of articulation with the bones of the lower limb. These are followed by a second row of four bones, referred to as the centralia (singular: centrale), and then a row of five distal tarsals, each articulating with a single metatarsal. In the great majority of tetrapods, including all of those alive today, this simple pattern is modified by the loss and fusion of various of the bones.[3] In reptiles and mammals, there are normally just two proximal tarsals, the calcaneus (equivalent to the amphibian fibulare) and the talus (probably derived from a fusion of multiple bones). In mammals, including humans, the talus forms a hinge joint with the tibia, a feature especially well developed in the artiodactyls. The calcaneus is also modified, forming a heel for the attachment of the Achilles tendon. Neither of these adaptations is found in reptiles, which have a relatively simple structure to both bones.[3] The fifth distal tarsal disappears relatively early in evolution, with the remainder becoming the cuneiform and cuboid bones. Reptiles usually retain two centralia, while mammals typically have only one (the navicular).[3] In birds, the tarsus has disappeared, with the proximal tarsals having fused with the tibia, the centralia having disappeared, and the distal bones having fused with the metatarsals to form a single tarsometatarsus bone, effectively giving the leg a third segment" xsd:string {source="Wikipedia:Tarsus_(skeleton)"} [Term] @@ -217705,7 +321418,7 @@ xref: FMA:24492 xref: GAID:193 xref: galen:Metatarsal xref: MA:0000303 -xref: MESH:A02.835.232.300.492 +xref: MESH:D008682 xref: NCIT:C12752 xref: SCTID:302532000 xref: UMLS:C0025584 {source="ncithesaurus:Metatarsal_Bone"} @@ -217714,6 +321427,10 @@ is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0003821 {is_inferred="true"} ! metapodium bone is_a: UBERON:0012359 ! pedal digitopodium bone is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0000983 ! metatarsus region +relationship: connected_to UBERON:0001447 ! tarsal bone +relationship: connected_to UBERON:0001449 ! phalanx of pes relationship: part_of UBERON:0010545 ! metatarsus skeleton property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png xsd:anyURI @@ -217751,6 +321468,8 @@ is_a: UBERON:0003221 ! phalanx is_a: UBERON:0003608 ! hindlimb long bone is_a: UBERON:0004248 ! pedal digit bone is_a: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0002387 ! pes relationship: develops_from UBERON:0010685 ! pedal digit phalanx cartilage element property_value: UBPROP:0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that make the five digits of the pes. The terminal phalanges are much smaller than the proximal and penultimate phalanges. The typical phalangeal formula of the pes, in a medial to lateral sequence, is 2(1)-2-3-4(3)-3(2).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000930", ontology="AAO", source="AAO:LAP"} @@ -217774,7 +321493,7 @@ xref: EMAPA:19134 xref: FMA:24496 xref: galen:Calcaneum xref: MA:0001348 -xref: MESH:A02.835.232.300.710.300 +xref: MESH:D002111 xref: NCIT:C32250 xref: SCTID:182099002 xref: UMLS:C0006655 {source="ncithesaurus:Calcaneum"} @@ -217782,8 +321501,11 @@ xref: VSAO:0005016 xref: Wikipedia:Calcaneus is_a: UBERON:0011679 ! proximal tarsal bone is_a: UBERON:0015014 ! calcaneum endochondral element +intersection_of: UBERON:0015014 ! calcaneum endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: BSPO:0001115 UBERON:0009879 ! tarsal skeleton relationship: develops_from UBERON:0010842 ! calcaneum cartilage element -property_value: depicted:by Subtalar:Joint.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG xsd:anyURI property_value: UBPROP:0000007 "calcaneal" xsd:string property_value: UBPROP:0000008 "synonymous with the fibulare of basal tetrapods." xsd:string @@ -217880,6 +321602,8 @@ xref: NCIT:C52718 xref: SCTID:245947005 xref: UMLS:C0222088 {source="ncithesaurus:Eyelid_Skin"} is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] @@ -217904,6 +321628,15 @@ intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0001833 ! lip relationship: part_of UBERON:0001833 ! lip +[Term] +id: UBERON:0001459 +name: skin of external ear +is_a: UBERON:0001084 ! skin of head +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001691 ! external ear +relationship: part_of UBERON:0001757 ! pinna + [Term] id: UBERON:0001460 name: arm @@ -217924,13 +321657,14 @@ xref: EHDAA:8275 xref: EMAPA:17413 xref: GAID:52 xref: MA:0000033 -xref: MESH:A01.378.800 xref: MESH:D001132 xref: OpenCyc:Mx4rvVjp5ZwpEbGdrcN5Y29ycA xref: VHOG:0000339 xref: Wikipedia:Arm is_a: UBERON:0006058 ! multi-limb segment region is_a: UBERON:0008785 ! upper limb segment +relationship: distally_connected_to UBERON:0002398 ! manus +relationship: proximally_connected_to UBERON:0001467 ! shoulder property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Upperarm.jpg xsd:anyURI property_value: editor_note "currently declared as overlapping hand, as AOs disagree over whether some wrist parts are in the arm or hand" xsd:string property_value: IAO:0000232 "this class refers to the combination of the stylopod and zeugopod of a forelimb. Sometimes (cf FMA), 'arm' denotes the stylopod only; sometimes (cf MA), 'arm' denotes the part of the forelimb covering both (i.e. shoulder to hand). Also note distinction between arm and forelimb: hand is part of forelimb, but not part of arm" xsd:string @@ -217965,7 +321699,7 @@ xref: VHOG:0000340 xref: Wikipedia:Elbow is_a: UBERON:0008785 ! upper limb segment relationship: part_of UBERON:0001460 {source="EHDAA2"} ! arm -property_value: depicted:by Elbow:coude.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG xsd:anyURI property_value: UBPROP:0000007 "cubital" xsd:string property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group" xsd:string @@ -218010,9 +321744,12 @@ xref: UMLS:C0040067 {source="ncithesaurus:Hand_Digit_1"} xref: Wikipedia:Thumb is_a: UBERON:0006048 ! digit 1 is_a: UBERON:0019231 ! manual digit 1 or 5 +intersection_of: UBERON:0006048 ! digit 1 +intersection_of: part_of UBERON:0002398 ! manus +relationship: BSPO:0001113 UBERON:0002398 ! manus relationship: part_of UBERON:5001463 ! manual digit 1 plus metapodial segment property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Thumb-up.jpg xsd:anyURI -property_value: depicted:by Thumbs:up.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2c/Thumbs_up.jpg xsd:anyURI property_value: RO:0002173 NCBITaxon:8782 property_value: UBPROP:0000008 "Not present in Anurans (Phenotype RCN Oct 2012)" xsd:string property_value: UBPROP:0000008 "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." xsd:string {scope="NCBITaxon:8782", seeAlso="UBERON:0012260", source="PMID:10220427", source="PhenoscapeRCN"} @@ -218047,6 +321784,7 @@ xref: UMLS:C0019552 {source="ncithesaurus:Hip"} xref: VHOG:0000346 xref: Wikipedia:Hip is_a: UBERON:0000475 ! organism subdivision +relationship: overlaps UBERON:0001271 ! pelvic girdle region relationship: part_of UBERON:0010709 ! pelvic complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Hip.jpg xsd:anyURI property_value: UBPROP:0000003 "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000346", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.333", source="http://bgee.unil.ch/"} @@ -218059,6 +321797,7 @@ name: knee namespace: uberon def: "A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod." [https://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "knee region" EXACT [] @@ -218079,6 +321818,7 @@ xref: VHOG:0000347 is_a: UBERON:0008784 ! lower limb segment relationship: part_of UBERON:0000978 ! leg property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8d/Male_Knee_by_David_Shankbone.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001466 @@ -218115,6 +321855,8 @@ xref: UMLS:C0040357 {source="ncithesaurus:Toe"} xref: Wikipedia:Toe xref: XAO:0003035 is_a: UBERON:0002544 ! digit +intersection_of: UBERON:0002544 ! digit +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0012142 {source="PHENOSCAPE:ni"} ! pedal digitopodium region relationship: part_of UBERON:5001466 ! pedal digit plus metapodial segment property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5e/Toes.jpg xsd:anyURI @@ -218147,6 +321889,9 @@ xref: UMLS:C0037004 {source="ncithesaurus:Shoulder"} xref: VHOG:0000342 xref: Wikipedia:Shoulder is_a: UBERON:0000475 ! organism subdivision +relationship: has_part UBERON:0016884 ! shoulder joint +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda +relationship: overlaps UBERON:0001421 ! pectoral girdle region relationship: part_of UBERON:0010708 ! pectoral complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/90/Shoulderjoint.PNG xsd:anyURI property_value: UBPROP:0000003 "(...) endochondral elements of the early tetrapod shoulder develop from two centers of ossification, giving rise to a scapula and a 'coracoid'.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000342", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.332", source="http://bgee.unil.ch/"} @@ -218169,9 +321914,36 @@ xref: NCIT:C49577 xref: SCTID:244512000 xref: UMLS:C1182940 {source="ncithesaurus:Vertebral_Joint"} is_a: UBERON:0002216 {source="FMA"} ! symphysis +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001075 {cardinality="2"} ! bony vertebral centrum +relationship: connects UBERON:0001075 ! bony vertebral centrum relationship: part_of UBERON:0001130 {source="FMA"} ! vertebral column property_value: UBPROP:0000012 "FMA has 'intervertebral joint' as a GAT, and has two distinct classes 'intervertebral symphysis' and 'intervertebral syndesmosis', but note that the latter do not connect the centra" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0001469 +name: sternoclavicular joint +is_a: UBERON:0011108 ! synovial joint of pectoral girdle +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000975 ! sternum +intersection_of: connects UBERON:0001105 ! clavicle bone +relationship: connects UBERON:0000975 ! sternum +relationship: connects UBERON:0001105 ! clavicle bone + +[Term] +id: UBERON:0001470 +name: glenohumeral joint +is_a: UBERON:0011108 ! synovial joint of pectoral girdle +is_a: UBERON:0011139 ! synovial limb joint +is_a: UBERON:0016884 ! shoulder joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000976 ! humerus +intersection_of: connects UBERON:0006849 ! scapula +relationship: adjacent_to UBERON:0006657 ! glenoid fossa +relationship: connects UBERON:0000976 ! humerus +relationship: connects UBERON:0006849 ! scapula +relationship: part_of UBERON:0004753 ! scapulocoracoid + [Term] id: UBERON:0001471 name: skin of prepuce of penis @@ -218187,14 +321959,27 @@ xref: MA:0001744 xref: SCTID:39059001 xref: VHOG:0001342 is_a: UBERON:0001331 ! skin of penis +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001332 ! prepuce of penis +relationship: contributes_to_morphology_of UBERON:0000989 ! penis relationship: part_of UBERON:0001332 ! prepuce of penis +[Term] +id: UBERON:0001472 +name: vaginal venous plexus +is_a: UBERON:0001593 ! venous plexus +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0001593 ! venous plexus +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + [Term] id: UBERON:0001473 name: lymphatic vessel namespace: uberon def: "A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]." [BTO:0000752, Wikipedia:Lymphatic_vessel] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -218208,6 +321993,7 @@ xref: EMAPA:35532 xref: FMA:30315 xref: MA:0000138 xref: MAT:0000443 +xref: MESH:D042601 xref: NCIT:C33038 xref: OpenCyc:Mx4rwA1fYZwpEbGdrcN5Y29ycA xref: SCTID:279089004 @@ -218216,10 +322002,17 @@ xref: UMLS:C0229889 {source="ncithesaurus:Lymphatic_Vessel"} xref: VHOG:0001249 xref: Wikipedia:Lymphatic_vessel xref: XAO:0000375 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000055 ! vessel +intersection_of: UBERON:0000055 ! vessel +intersection_of: part_of UBERON:0004536 ! lymph vasculature +disjoint_from: UBERON:0001981 ! blood vessel +relationship: contributes_to_morphology_of UBERON:0002405 ! immune system +relationship: has_part UBERON:0002391 ! lymph relationship: part_of UBERON:0004536 ! lymph vasculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg xsd:anyURI property_value: RO:0002174 NCBITaxon:8342 {source="DOI:10.1152/japplphysiol.00201.2013"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005105", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "A vessel that contains or conveys lymph.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011005", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001249", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627", source="http://bgee.unil.ch/"} @@ -218274,8 +322067,9 @@ intersection_of: UBERON:0004765 ! skeletal element intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue disjoint_from: UBERON:0001630 ! muscle organ disjoint_from: UBERON:0005090 ! muscle structure +disjoint_from: UBERON:0010538 ! paired limb/fin segment relationship: composed_primarily_of UBERON:0002481 {source="VSAO-modified"} ! bone tissue -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: RO:0002171 UBERON:0001015 property_value: RO:0002171 UBERON:0001630 property_value: RO:0002171 UBERON:0002385 @@ -218317,7 +322111,20 @@ xref: Wikipedia:Deltoid_muscle is_a: UBERON:0001482 {source="FMA"} ! muscle of shoulder is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034908 ! scapular muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0000976 ! humerus +intersection_of: attaches_to UBERON:0001105 ! clavicle bone +intersection_of: attaches_to UBERON:0006849 ! scapula +relationship: attaches_to UBERON:0000976 ! humerus +relationship: attaches_to UBERON:0001105 ! clavicle bone +relationship: attaches_to UBERON:0002498 ! deltopectoral crest relationship: develops_from UBERON:0006219 {source="EHDAA2"} ! deltoid pre-muscle mass +relationship: has_muscle_antagonist UBERON:0001112 ! latissimus dorsi muscle +relationship: has_muscle_insertion UBERON:0002498 ! deltopectoral crest +relationship: has_muscle_origin UBERON:0001105 ! clavicle bone +relationship: has_muscle_origin UBERON:0002497 ! acromion +relationship: has_muscle_origin UBERON:0006849 ! scapula +relationship: innervated_by UBERON:0001493 ! axillary nerve relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/93/Deltoideus.png xsd:anyURI property_value: UBPROP:0000001 "Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010716", ontology="AAO", source="AAO:MEJ"} @@ -218345,6 +322152,8 @@ xref: UMLS:C0036846 {source="ncithesaurus:Sesamoid_Bone"} xref: Wikipedia:Sesamoid_bone is_a: UBERON:0013630 {source="UBERON:cjm"} ! short bone is_a: UBERON:0013631 ! sesamoid element +intersection_of: UBERON:0013631 ! sesamoid element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray350.png xsd:anyURI [Term] @@ -218359,6 +322168,8 @@ xref: SCTID:306715004 is_a: UBERON:0001435 ! carpal bone is_a: UBERON:0014395 ! proximal mesopodial bone is_a: UBERON:0015078 ! proximal carpal endochondral element +intersection_of: UBERON:0015078 ! proximal carpal endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0015079 ! proximal carpal cartilage [Term] @@ -218390,9 +322201,22 @@ synonym: "shoulder muscle organ" EXACT [OBOL:automatic] xref: EMAPA:36154 xref: FMA:33531 xref: MA:0000633 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0003461 ! shoulder bone +relationship: attaches_to UBERON:0003461 ! shoulder bone +relationship: overlaps UBERON:0001467 ! shoulder relationship: part_of UBERON:0004476 {source="prolog"} ! musculature of shoulder +[Term] +id: UBERON:0001483 +name: skin of shoulder +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001467 ! shoulder +relationship: part_of UBERON:0001467 ! shoulder + [Term] id: UBERON:0001484 name: articular capsule @@ -218438,6 +322262,7 @@ name: knee joint namespace: uberon def: "The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]." [Wikipedia:Knee] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "articulatio genus" RELATED LATIN [Wikipedia:Knee] @@ -218457,9 +322282,17 @@ xref: VHOG:0001003 xref: Wikipedia:Knee is_a: UBERON:0003840 ! hindlimb joint is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000979 ! tibia +intersection_of: connects UBERON:0000981 ! femur +intersection_of: connects UBERON:0002446 ! patella +relationship: connects UBERON:0000979 ! tibia +relationship: connects UBERON:0000981 ! femur +relationship: connects UBERON:0002446 ! patella relationship: develops_from UBERON:0006256 {evidence="definitional"} ! knee joint primordium relationship: part_of UBERON:0001465 ! knee property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ca/Knee.agr.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001486 @@ -218489,6 +322322,28 @@ is_a: UBERON:0011107 {source="FMA"} ! synovial joint of pelvic girdle relationship: develops_from UBERON:0006244 {evidence="definitional"} ! hip joint primordium relationship: part_of UBERON:0001464 {source="FMA"} ! hip +[Term] +id: UBERON:0001487 +name: pes joint +is_a: UBERON:0003840 ! hindlimb joint +is_a: UBERON:0003841 ! autopod joint +is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes + +[Term] +id: UBERON:0001488 +name: ankle joint +is_a: UBERON:0003840 ! hindlimb joint +is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001445 ! skeleton of pes +intersection_of: connects UBERON:0010720 ! hindlimb zeugopod skeleton +relationship: connects UBERON:0001445 ! skeleton of pes +relationship: connects UBERON:0010720 ! hindlimb zeugopod skeleton +relationship: overlaps UBERON:0002387 ! pes + [Term] id: UBERON:0001489 name: manus joint @@ -218508,6 +322363,8 @@ xref: Wikipedia:Joints_of_hand is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0002398 ! manus property_value: editor_note "TODO check FMA - use the set class for now" xsd:string property_value: UBPROP:0000202 FMA:71345 @@ -218536,10 +322393,44 @@ xref: VHOG:0000997 xref: Wikipedia:Elbow is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000976 ! humerus +intersection_of: connects UBERON:0010703 ! forelimb zeugopod skeleton +relationship: connects UBERON:0000976 ! humerus +relationship: connects UBERON:0010703 ! forelimb zeugopod skeleton relationship: develops_from UBERON:0006224 {evidence="definitional"} ! elbow joint primordium relationship: part_of UBERON:0001461 ! elbow property_value: UBPROP:0000008 "In human anatomy, the elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis" xsd:string {source="HP"} +[Term] +id: UBERON:0001491 +name: wrist joint +is_a: UBERON:0001489 ! manus joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0009880 ! carpal skeleton +intersection_of: connects UBERON:0010703 ! forelimb zeugopod skeleton +relationship: connects UBERON:0009880 ! carpal skeleton +relationship: connects UBERON:0010703 ! forelimb zeugopod skeleton +relationship: part_of UBERON:0004452 ! carpal region + +[Term] +id: UBERON:0001492 +name: radial nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0003433 ! arm nerve +relationship: branching_part_of UBERON:0001814 ! brachial nerve plexus +relationship: innervates UBERON:0001509 ! triceps brachii +relationship: innervates UBERON:0003403 ! skin of forearm +relationship: innervates UBERON:0004487 ! musculature of forelimb zeugopod + +[Term] +id: UBERON:0001493 +name: axillary nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0003433 ! arm nerve +relationship: innervates UBERON:0009472 ! axilla +relationship: part_of UBERON:0001814 ! brachial nerve plexus + [Term] id: UBERON:0001495 name: pectoral muscle @@ -218571,7 +322462,7 @@ is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0008196 {source="FMA"} ! muscle of pectoral girdle relationship: develops_from UBERON:0010984 ! pectoral pre-muscle mass -property_value: depicted:by Pectoralis:major.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png xsd:anyURI property_value: UBPROP:0000001 "Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010727", ontology="AAO", source="AAO:MEJ"} [Term] @@ -218579,6 +322470,7 @@ id: UBERON:0001496 name: ascending aorta namespace: uberon def: "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." [GO:0035905, Wikipedia:Ascending_aorta] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aorta ascendens" RELATED LATIN [Wikipedia:Ascending_aorta] @@ -218597,8 +322489,12 @@ xref: UMLS:C0003956 {source="ncithesaurus:Ascending_Aorta"} xref: Wikipedia:Ascending_aorta is_a: UBERON:0001515 ! thoracic aorta is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: develops_from UBERON:0005338 {source="EHDAA2"} ! outflow tract aortic component +relationship: has_developmental_contribution_from UBERON:0002061 ! truncus arteriosus +relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001497 @@ -218622,9 +322518,19 @@ xref: MA:0000537 xref: RETIRED_EHDAA2:0001430 is_a: UBERON:0001325 ! muscle of pelvis is_a: UBERON:0010890 ! pelvic complex muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001271 ! pelvic girdle region relationship: part_of UBERON:0004470 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! musculature of pelvic girdle property_value: UBPROP:0000012 "Note that in MA, this is a subclass of pelvis muscle; in FMA this is a hindlimb muscle, but recall in FMA hindlimb includes the girdle." xsd:string {external_ontology="MA"} +[Term] +id: UBERON:0001498 +name: muscle of pes +is_a: UBERON:0003663 ! hindlimb muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0004488 ! musculature of pes + [Term] id: UBERON:0001499 name: muscle of arm @@ -218643,6 +322549,8 @@ xref: EMAPA:36053 xref: MA:0000594 xref: RETIRED_EHDAA2:0000142 is_a: UBERON:0003662 ! forelimb muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001460 ! arm relationship: part_of UBERON:0004474 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! musculature of arm property_value: UBPROP:0000013 "See notes on UBERON:0001460 for possible terminological confusion over term 'arm'. MA uses this consistent with uberon (forelimb muscle is subdivided into shoulder, arm and hand)" xsd:string @@ -218661,6 +322569,8 @@ xref: FMA:37372 xref: MA:0000628 xref: SCTID:110540008 is_a: UBERON:0003662 ! forelimb muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0004489 {source="prolog"} ! musculature of manus [Term] @@ -218726,7 +322636,13 @@ xref: SCTID:265802004 xref: UMLS:C0559499 {source="ncithesaurus:Biceps"} xref: VHOG:0000861 xref: Wikipedia:Biceps_brachii_muscle +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004255 ! forelimb stylopod muscle +relationship: has_muscle_antagonist UBERON:0001509 ! triceps brachii +relationship: has_muscle_insertion UBERON:0001423 ! radius bone +relationship: has_muscle_origin UBERON:0006633 ! coracoid process of scapula +relationship: has_muscle_origin UBERON:0010760 ! supraglenoid tubercle +relationship: innervated_by UBERON:0003724 ! musculocutaneous nerve property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/5d/Biceps_brachii_muscle06.png xsd:anyURI [Term] @@ -218734,6 +322650,7 @@ id: UBERON:0001508 name: arch of aorta namespace: uberon def: "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." [ISBN:0-683-40008-8, MP:0004113] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aortic arch" RELATED [FMA:3768] @@ -218751,12 +322668,14 @@ xref: VHOG:0001196 xref: Wikipedia:Arch_of_aorta is_a: UBERON:0001515 ! thoracic aorta is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: connected_to UBERON:0001496 ! ascending aorta relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: develops_from UBERON:0003121 {notes="left arch 4 in human", source="embryology.ch"} ! pharyngeal arch artery 4 relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: IAO:0000232 "Do not confuse with aortic arch" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001196", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/arch+of+aorta"} property_value: UBPROP:0000003 "The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001196", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460 and p.461 Figure 12.20", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "birds have right aortic arch, mammals left." xsd:string @@ -218787,7 +322706,37 @@ xref: Wikipedia:Triceps_brachii_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0004255 ! forelimb stylopod muscle is_a: UBERON:0034908 ! scapular muscle -property_value: depicted:by Triceps:brachii.png xsd:anyURI +relationship: has_muscle_antagonist UBERON:0001507 ! biceps brachii +relationship: has_muscle_insertion UBERON:0006810 ! olecranon +relationship: has_muscle_origin UBERON:0000976 ! humerus +relationship: has_muscle_origin UBERON:0006849 ! scapula +relationship: innervated_by UBERON:0001492 ! radial nerve +relationship: innervated_by UBERON:0001493 ! axillary nerve +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/83/Triceps_brachii.png xsd:anyURI + +[Term] +id: UBERON:0001510 +name: skin of knee +is_a: UBERON:0001511 ! skin of leg +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001465 ! knee +relationship: part_of UBERON:0001465 ! knee + +[Term] +id: UBERON:0001511 +name: skin of leg +is_a: UBERON:0003532 ! hindlimb skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0000978 ! leg +relationship: part_of UBERON:0000978 ! leg + +[Term] +id: UBERON:0001512 +name: skin of ankle +is_a: UBERON:0001513 ! skin of pes +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0004454 ! tarsal region +relationship: part_of UBERON:0004454 ! tarsal region [Term] id: UBERON:0001513 @@ -218806,6 +322755,8 @@ xref: SCTID:181529000 xref: UMLS:C0222289 {source="ncithesaurus:Foot_Skin"} is_a: UBERON:0003532 {source="MA"} ! hindlimb skin is_a: UBERON:0015790 ! autopod skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0002387 ! pes [Term] @@ -218813,6 +322764,7 @@ id: UBERON:0001514 name: descending aorta namespace: uberon def: "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." [GO:0035906, Wikipedia:Descending_aorta] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aorta descendens" RELATED LATIN [Wikipedia:Descending_aorta] @@ -218828,10 +322780,12 @@ xref: SCTID:261399002 xref: UMLS:C0011666 {source="ncithesaurus:Descending_Aorta"} xref: Wikipedia:Descending_aorta is_a: UBERON:0005800 {source="FMA"} ! section of aorta +relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0005805 {source="Wikipedia"} ! dorsal aorta relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta relationship: has_developmental_contribution_from UBERON:0005622 ! right dorsal aorta property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "results from fusion of left and right dorsal aortae" xsd:string [Term] @@ -218872,6 +322826,7 @@ name: abdominal aorta namespace: uberon def: "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." [BTO:0002976, Wikipedia:Abdominal_aorta] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "abdominal part of aorta" EXACT [FMA:3789] @@ -218896,11 +322851,29 @@ xref: SCTID:244231007 xref: UMLS:C0003484 {source="ncithesaurus:Abdominal_Aorta"} xref: Wikipedia:Abdominal_aorta is_a: UBERON:0005800 ! section of aorta +relationship: connected_to UBERON:0002345 ! descending thoracic aorta relationship: contributes_to_morphology_of UBERON:0001514 ! descending aorta relationship: overlaps UBERON:0000916 ! abdomen relationship: part_of UBERON:0001514 {source="FMA"} ! descending aorta property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png xsd:anyURI property_value: editor_note "Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates" xsd:string +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001517 +name: skin of elbow +is_a: UBERON:0002427 ! arm skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001461 ! elbow +relationship: part_of UBERON:0001461 ! elbow + +[Term] +id: UBERON:0001518 +name: skin of wrist +is_a: UBERON:0001519 ! skin of manus +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0004452 ! carpal region +relationship: part_of UBERON:0004452 ! carpal region [Term] id: UBERON:0001519 @@ -218920,6 +322893,8 @@ xref: SCTID:181527003 xref: UMLS:C0222224 {source="ncithesaurus:Hand_Skin"} is_a: UBERON:0003531 ! forelimb skin is_a: UBERON:0015790 ! autopod skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0002398 ! manus [Term] @@ -218939,8 +322914,13 @@ xref: OpenCyc:Mx4rvlO2nJwpEbGdrcN5Y29ycA xref: SCTID:264167003 is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0011139 {source="FMA"} ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001423 ! radius bone +intersection_of: connects UBERON:0001424 ! ulna +relationship: connects UBERON:0001423 ! radius bone +relationship: connects UBERON:0001424 ! ulna relationship: part_of UBERON:0002386 ! forelimb zeugopod -property_value: depicted:by Forearm:labeled.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png xsd:anyURI [Term] id: UBERON:0001529 @@ -218948,6 +322928,7 @@ name: brachiocephalic artery namespace: uberon def: "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." [MGI:csmith, MP:0010663] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brachiocephalic trunk" EXACT [MA:0001922] @@ -218970,14 +322951,17 @@ xref: UMLS:C0006094 {source="ncithesaurus:Innominate_Artery"} xref: Wikipedia:Brachiocephalic_artery is_a: UBERON:0004573 ! systemic artery relationship: channels_from UBERON:0001508 ! arch of aorta +relationship: connected_to UBERON:0001508 ! arch of aorta relationship: part_of UBERON:0007204 ! brachiocephalic vasculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001530 name: common carotid artery plus branches namespace: uberon def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [Wikipedia:Common_carotid_artery] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "a. carotis communis" RELATED LATIN [Wikipedia:Common_carotid_artery] @@ -219000,11 +322984,13 @@ xref: VHOG:0000272 xref: Wikipedia:Common_carotid_artery is_a: UBERON:0004573 {source="FMA"} ! systemic artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0004363 {source="Wikipedia"} ! pharyngeal arch artery relationship: existence_starts_during UBERON:0000068 ! embryo stage property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: editor_note "we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery'" xsd:string property_value: IAO:0000232 "This class represents the adult and developing structures'" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae" xsd:string [Term] @@ -219012,6 +322998,7 @@ id: UBERON:0001531 name: right common carotid artery plus branches namespace: uberon def: "The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk." [UBERON:cjm] +subset: human_reference_atlas subset: uberon_slim synonym: "right common carotid artery" EXACT [MA:0001928] synonym: "right common carotid artery" RELATED [FMA:3941] @@ -219027,7 +323014,9 @@ xref: UMLS:C0226086 {source="ncithesaurus:Right_Common_Carotid_Artery"} xref: Wikipedia:Right_common_carotid_artery is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches relationship: branching_part_of UBERON:0001529 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! brachiocephalic artery +relationship: connected_to UBERON:0001529 ! brachiocephalic artery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" xsd:string [Term] @@ -219036,6 +323025,7 @@ name: internal carotid artery namespace: uberon def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]." [MGI:anna] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -219072,6 +323062,7 @@ relationship: develops_from UBERON:2001053 {source="cjm"} ! future internal caro relationship: supplies UBERON:0000955 ! brain relationship: supplies UBERON:0000970 ! eye property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray513.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Each of two arteries starting at the bifurcation of the common carotid arteries through which blood circulates to many structures and organs in the head. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000267", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Internal+carotid+artery"} property_value: UBPROP:0000001 "One of the major arteries of the head, it is the as the cranial continuation of the aortic arches and the dorsal aorta. It curves ventrally before resuming a dorsal course as it enters the head proper, and it lies ventral to the internal jugular vein. The internal carotid artery gives off palatine, ophthalmic, and cerebral branches by stage NF stage 41.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011054", ontology="AAO", source="PMID:12606281"} @@ -219080,6 +323071,7 @@ id: UBERON:0001533 name: subclavian artery namespace: uberon def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: unverified_taxonomic_grouping @@ -219107,10 +323099,14 @@ xref: Wikipedia:Subclavian_artery xref: XAO:0000365 xref: ZFA:0005086 is_a: UBERON:0004573 ! systemic artery +relationship: connected_to UBERON:0001508 ! arch of aorta relationship: develops_from UBERON:0002457 {source="EHDAA2"} ! intersomitic artery relationship: develops_from UBERON:0005622 {source="EHDAA2"} ! right dorsal aorta +relationship: overlaps UBERON:0000915 ! thoracic segment of trunk +relationship: supplies UBERON:0004710 ! pectoral appendage property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI property_value: editor_note "Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO)" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010232", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP]" xsd:string {source="Wikipedia:Subclavian_artery"} property_value: UBPROP:0000001 "The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005086", ontology="TAO", source="ZFIN:curator"} @@ -219120,6 +323116,7 @@ id: UBERON:0001534 name: right subclavian artery namespace: uberon def: "The subclavian artery that supplies the right pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia dextra" EXACT LATIN [FMA:3953, FMA:TA] @@ -219135,7 +323132,14 @@ xref: UMLS:C0226261 {source="ncithesaurus:Right_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001533 ! subclavian artery +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: branching_part_of UBERON:0001529 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! brachiocephalic artery +relationship: connected_to UBERON:0001529 ! brachiocephalic artery +relationship: develops_from UBERON:0003121 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="right arch 4 in human", source="embryology.ch"} ! pharyngeal arch artery 4 +relationship: in_right_side_of UBERON:0000468 ! multicellular organism property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery" xsd:string property_value: UBPROP:0000011 "proximal part arises from right 4th aortic arch in humans" xsd:string @@ -219145,6 +323149,7 @@ name: vertebral artery namespace: uberon def: "The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck." [ISBN:0-683-40008-8, MP:0011513] comment: The two vertebral arteries and the basilar artery are sometimes together called the vertebrobasilar system, which supplies blood to the posterior part of circle of Willis and anastomoses with blood supplied to the anterior part of the circle of Willis from the carotid arteries. [WP,unvetted] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -219166,13 +323171,16 @@ xref: VHOG:0000263 xref: Wikipedia:Vertebral_artery xref: ZFA:0005033 is_a: UBERON:0002458 ! spinal artery -property_value: depicted:by Vertebral:artery.png xsd:anyURI +relationship: branching_part_of UBERON:0001533 ! subclavian artery +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/ff/Vertebral_artery.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001536 name: left common carotid artery plus branches namespace: uberon def: "The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax." [UBERON:cjm] +subset: human_reference_atlas subset: uberon_slim synonym: "left common carotid artery" EXACT [MA:0001927] synonym: "left common carotid artery" RELATED [FMA:4058] @@ -219188,6 +323196,7 @@ xref: UMLS:C0226087 {source="ncithesaurus:Left_Common_Carotid_Artery"} xref: Wikipedia:Left_common_carotid_artery is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" xsd:string [Term] @@ -219206,6 +323215,8 @@ xref: UMLS:C0729596 {source="ncithesaurus:Inguinal_Lymph_Node"} xref: Wikipedia:Inguinal_lymph_node is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node is_a: UBERON:0005173 ! abdominal segment element +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0008337 ! inguinal part of abdomen relationship: part_of UBERON:0008337 ! inguinal part of abdomen [Term] @@ -219213,6 +323224,7 @@ id: UBERON:0001543 name: popliteal lymph node namespace: uberon def: "The lymph nodes which drain the legs; contained in the popliteal fossa." [MGI:cwg, MP:0002352, Wikipedia:Popliteal_lymph_node] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "popliteal glands" RELATED [Wikipedia:Popliteal_lymph_nodes] @@ -219226,15 +323238,30 @@ xref: UMLS:C0588057 {source="ncithesaurus:Popliteal_Lymph_Node"} xref: Wikipedia:Popliteal_lymph_node is_a: UBERON:0003968 {source="CL:tm"} ! peripheral lymph node is_a: UBERON:0016398 ! lymph node of lower limb +intersection_of: UBERON:0000029 ! lymph node +intersection_of: located_in UBERON:0016400 ! infrapatellar fat pad +intersection_of: part_of UBERON:0001485 ! knee joint +relationship: located_in UBERON:0016400 ! infrapatellar fat pad relationship: part_of UBERON:0001485 ! knee joint property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "In the popliteal fossa between biceps femoris m. and semitendinosus m.." xsd:string {source="PMID:16624319", taxon="NCBITaxon:10090"} +[Term] +id: UBERON:0001549 +name: dorsal metatarsal vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0000983 ! metatarsus region +relationship: drains UBERON:0000983 ! metatarsus region +relationship: tributary_of UBERON:0008783 ! dorsal venous arch + [Term] id: UBERON:0001552 name: kidney arcuate artery namespace: uberon def: "One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries." [MP:0011315, Wikipedia:Arcuate_artery_of_the_foot] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arcuate artery" BROAD [MA:0002583] @@ -219247,6 +323274,15 @@ is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray553.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001554 +name: skin of hip +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001464 ! hip +relationship: part_of UBERON:0001464 ! hip [Term] id: UBERON:0001555 @@ -219335,6 +323371,7 @@ xref: VHOG:0000406 xref: Wikipedia:Upper_respiratory_tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: has_part UBERON:0000004 ! nose property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI property_value: RO:0002171 UBERON:0001558 @@ -219345,6 +323382,7 @@ id: UBERON:0001558 name: lower respiratory tract namespace: uberon def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lower_respiratory_tract] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lower respiratory system" EXACT [] @@ -219356,11 +323394,11 @@ xref: OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g xref: SCTID:281488008 xref: VHOG:0000382 xref: Wikipedia:Lower_respiratory_tract -is_a: BFO:0000040 ! material entity is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: has_part UBERON:0000170 ! pair of lungs property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001560 @@ -219370,6 +323408,7 @@ subset: non_informative synonym: "organ neck" EXACT [] xref: FMA:45733 is_a: UBERON:0034944 {source="FMA"} ! zone of organ +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0001564 @@ -219393,7 +323432,7 @@ xref: UMLS:C0224159 {source="ncithesaurus:Mylohyoid"} xref: Wikipedia:Mylohyoid_muscle is_a: UBERON:0008571 {source="FMA"} ! suprahyoid muscle is_a: UBERON:0018544 ! trigeminal nerve muscle -property_value: depicted:by Mylohyoid:muscle.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/92/Mylohyoid_muscle.PNG xsd:anyURI property_value: UBPROP:0000001 "The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking R and L mylohyoid and the mandible.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} [Term] @@ -219418,7 +323457,7 @@ xref: UMLS:C0224160 {source="ncithesaurus:Geniohyoid"} xref: Wikipedia:Geniohyoid_muscle is_a: UBERON:0008571 {source="FMA"} ! suprahyoid muscle is_a: UBERON:0011151 ! jaw depressor muscle -property_value: depicted:by Geniohyoid:muscle.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2c/Geniohyoid_muscle.PNG xsd:anyURI property_value: UBPROP:0000001 "The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by C1.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} property_value: UBPROP:0000014 "draws hyoid cranially" xsd:string @@ -219446,8 +323485,9 @@ xref: UMLS:C0007966 {source="ncithesaurus:Cheek"} xref: Wikipedia:Cheek is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0034929 ! external soft tissue zone +relationship: in_lateral_side_of UBERON:0001456 ! face relationship: part_of UBERON:0004089 ! midface -property_value: depicted:by Chica:cachetona.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a9/Chica_cachetona.jpg xsd:anyURI property_value: UBPROP:0000001 "Surface structure that includes the scales, skin, and muscles that are located ventral and posterior to the eye.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002113", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000007 "buccal" xsd:string property_value: UBPROP:0000008 "In many animals the inside of the cheek is lined with mucous membrane covered with stratified squamous epithelium and supplied with secretions from buccal glands." xsd:string @@ -219527,7 +323567,7 @@ xref: AAO:0010663 xref: EMAPA:18277 xref: FMA:46691 xref: MA:0002317 -xref: MFMO_0000064 +xref: MFMO:0000064 xref: NCIT:C53161 xref: SCTID:244785008 xref: UMLS:C0224196 {source="ncithesaurus:Hyoglossus_Muscle"} @@ -219675,7 +323715,10 @@ xref: Wikipedia:Facial_muscles xref: XAO:0001013 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015789 ! cranial or facial muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: innervated_by UBERON:0001647 ! facial nerve relationship: develops_from UBERON:0003066 {source="FEED", source="Wikipedia"} ! pharyngeal arch 2 +relationship: innervated_by UBERON:0001647 ! facial nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png xsd:anyURI [Term] @@ -219705,6 +323748,7 @@ id: UBERON:0001579 name: olfactory nerve namespace: uberon def: "Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]." [ISBN:0471209627, Wikipedia:Olfactory_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -219734,11 +323778,11 @@ xref: EMAPA:17797 xref: FMA:46787 xref: GAID:830 xref: HBA:9300 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=32 {source="BIRNLEX:1319"} xref: MA:0001096 xref: MBA:840 xref: MESH:D009832 xref: NCIT:C12759 +xref: neuronames:32 {source="BIRNLEX:1319"} xref: OpenCyc:Mx4rvZuXAJwpEbGdrcN5Y29ycA xref: SCTID:180937006 xref: TAO:0000249 @@ -219749,9 +323793,16 @@ xref: VHOG:0000703 xref: Wikipedia:Olfactory_nerve xref: XAO:0000426 xref: ZFA:0000249 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve +intersection_of: UBERON:0001785 ! cranial nerve +intersection_of: extends_fibers_into UBERON:0002264 ! olfactory bulb +intersection_of: innervates UBERON:0001997 ! olfactory epithelium relationship: develops_from UBERON:0003050 {source="ISBN:0471888893"} ! olfactory placode +relationship: extends_fibers_into UBERON:0002264 ! olfactory bulb +relationship: innervates UBERON:0001997 ! olfactory epithelium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/be/Gray771.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nerve that carries information from the olfactory epithelium through the olfactory bulb to the olfactory cortex of the telencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010088", ontology="AAO", source="AAO:DSM"} property_value: UBPROP:0000001 "Segment of neural tree organ which is continuous with the olfactory epithelium and an olfactory bulb[FMA:46787]." xsd:string {source="FMA:46787"} property_value: UBPROP:0000001 "The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB[MESH:A08.800.800.120.640]." xsd:string {source="MESH:A08.800.800.120.640"} @@ -219821,6 +323872,7 @@ id: UBERON:0001584 name: left subclavian artery namespace: uberon def: "The subclavian artery that supplies the left pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria subclavia (sinistra)" EXACT LATIN [FMA:4694, FMA:TA] @@ -219835,7 +323887,11 @@ xref: UMLS:C0226262 {source="ncithesaurus:Left_Subclavian_Artery"} xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001533 ! subclavian artery +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in humans, branches off the arch of aorta" xsd:string property_value: UBPROP:0000011 "arises from left intersegmental 6th artery in the region of the 6th -7th cervical segment in humans" xsd:string @@ -219845,6 +323901,7 @@ name: anterior vena cava namespace: uberon def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Superior_vena_cava] def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://en.wikipedia.org/wiki/Superior_vena_cava, http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cranial vena cava" RELATED [VHOG:0001195] @@ -219876,8 +323933,10 @@ xref: Wikipedia:Superior_vena_cava is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: drains UBERON:0000153 ! anterior region of body +relationship: connected_to UBERON:0002078 ! right cardiac atrium relationship: drains UBERON:0000153 ! anterior region of body property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001195", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455"} property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001195", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green)." xsd:string @@ -219888,6 +323947,7 @@ name: internal jugular vein namespace: uberon def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [http://en.wikipedia.org/wiki/Internal_jugular_vein] def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [Wikipedia:Internal_jugular_vein] +subset: human_reference_atlas subset: uberon_slim synonym: "internal jugular" EXACT [EHDAA2:0000877] synonym: "internal jugular venous tree" EXACT [] @@ -219911,16 +323971,58 @@ xref: UMLS:C0226550 {source="ncithesaurus:Internal_Jugular_Vein"} xref: Wikipedia:Internal_jugular_vein xref: XAO:0000382 is_a: UBERON:0004711 ! jugular vein +relationship: connected_to UBERON:0003711 ! brachiocephalic vein relationship: drains UBERON:0000955 ! brain relationship: drains UBERON:0001456 ! face property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010236", ontology="AAO", source="AAO:BJB"} +[Term] +id: UBERON:0001591 +name: thymic vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002370 ! thymus +relationship: drains UBERON:0002370 ! thymus +relationship: tributary_of UBERON:0003711 ! brachiocephalic vein + +[Term] +id: UBERON:0001592 +name: bronchial vein +namespace: uberon +def: "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." [Wikipedia:Bronchial_veins] +subset: human_reference_atlas +subset: uberon_slim +synonym: "bronchial venous tree" EXACT [] +xref: EMAPA:36284 +xref: FMA:4749 +xref: MA:0002088 +xref: NCIT:C53031 +xref: SCTID:198293000 +xref: UMLS:C0226650 {source="ncithesaurus:Bronchial_Vein"} +xref: Wikipedia:Bronchial_veins +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002185 ! bronchus +relationship: drains UBERON:0002185 ! bronchus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001593 +name: venous plexus +is_a: UBERON:0004537 ! blood vasculature +is_a: UBERON:0005629 ! vascular plexus +intersection_of: UBERON:0005629 ! vascular plexus +intersection_of: composed_primarily_of UBERON:0001638 ! vein +relationship: composed_primarily_of UBERON:0001638 ! vein + [Term] id: UBERON:0001594 name: azygos vein namespace: uberon def: "An unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava[MP]." [MP:0011569, Wikipedia:Azygos_vein] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "azygos venous tree" EXACT [] @@ -219936,8 +324038,9 @@ xref: UMLS:C0004526 {source="ncithesaurus:Azygos_Vein"} xref: Wikipedia:Azygos_vein is_a: UBERON:0001638 ! vein relationship: develops_from UBERON:0008268 {source="ISBN:0443065837"} ! right supracardinal vein -property_value: depicted:by Azygos:vein.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/b4/Azygos_vein.png xsd:anyURI property_value: editor_note "check development relationships in different species" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001597 @@ -220130,7 +324233,10 @@ xref: NCIT:C52802 xref: SCTID:244774006 xref: UMLS:C0224134 {source="ncithesaurus:Levator_Palpebrae_Superioris"} xref: Wikipedia:Levator_palpebrae_superioris +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001601 {source="FMA"} ! extra-ocular muscle +relationship: has_muscle_insertion UBERON:0004772 ! eyelid tarsus +relationship: has_muscle_origin UBERON:0001677 ! sphenoid bone relationship: part_of UBERON:0001711 {source="FMA"} ! eyelid property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png xsd:anyURI @@ -220190,11 +324296,98 @@ property_value: editor_note "revisit this, see issue #331" xsd:string property_value: UBPROP:0000008 "in aves, stromal mesenchymal cells may migrate to the iris and become skeletal" xsd:string property_value: UBPROP:0000008 "The muscle cells of the iris are smooth muscle in mammals and amphibians, but are striated muscle in birds and reptiles. Many fish have neither, and, as a result, their irides are unable to dilate and contract, so that the pupil always remains of a fixed size[Romer, via WP]" xsd:string +[Term] +id: UBERON:0001607 +name: sphincter pupillae +namespace: uberon +def: "A sphincter muscle that is part of the iris." [Wikipedia:Iris_sphincter_muscle] +subset: uberon_slim +synonym: "circular fibers" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "constrictor pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "iris constrictor" RELATED [] +synonym: "iris constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "iris sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "iris sphincter muscle" EXACT [BTO:0000656] +synonym: "M. sphincter pupillae" EXACT [] +synonym: "m. sphincter pupillae" RELATED LATIN [Wikipedia:Iris_sphincter_muscle] +synonym: "musculus sphincter pupillae" EXACT [BTO:0000656] +synonym: "pupillary constrictor muscle" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "pupillary sphincter" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "pupillary sphincter muscle" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "sphincter muscle of pupil" EXACT [BTO:0000656] +synonym: "sphincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "sphincter pupillae muscle" RELATED [Wikipedia:Iris_sphincter_muscle] +synonym: "spincter pupillae" RELATED [Wikipedia:Iris_sphincter_muscle] +xref: BTO:0000656 +xref: EMAPA:35788 +xref: FMA:49157 +xref: MA:0001289 +xref: NCIT:C33586 +xref: SCTID:280889004 +xref: UMLS:C0229189 {source="ncithesaurus:Sphincter_Pupillae_Muscle"} +xref: Wikipedia:Iris_sphincter_muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0001606 ! muscle of iris +is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle +is_a: UBERON:0007521 ! smooth muscle sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0001769 ! iris +relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm +relationship: has_muscle_antagonist UBERON:0001608 {source="dbpedia"} ! dilatator pupillae +relationship: has_muscle_insertion UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris +relationship: has_muscle_origin UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png xsd:anyURI +property_value: UBPROP:0000008 "In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted]" xsd:string +property_value: UBPROP:0000008 "WP says: It is found in vertebrates and some cephalopods; this class refers to the vertebrate structure" xsd:string +property_value: UBPROP:0000009 "constricts iris" xsd:string + +[Term] +id: UBERON:0001608 +name: dilatator pupillae +namespace: uberon +def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." [Wikipedia:Iris_dilator_muscle] +subset: uberon_slim +synonym: "dilator muscle of pupil" EXACT [] +synonym: "dilator of pupil" EXACT [] +synonym: "dilator pupillae" EXACT [] +synonym: "dilator pupillae muscle" EXACT [Wikipedia:Iris_dilator_muscle] +synonym: "dilator pupillae muscle" RELATED [BTO:0001371] +synonym: "iris dilator" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "iris dilator muscle" EXACT [BTO:0001371] +synonym: "musculus dilatator pupillae" EXACT LATIN [FMA:49158, FMA:TA] +synonym: "musculus dilatator pupillae" RELATED LATIN [Wikipedia:Iris_dilator_muscle] +synonym: "musculus dilator pupillae" RELATED [BTO:0001371] +synonym: "pupil dilator" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "pupil dilator muscle" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "pupillary dilator" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "pupillary dilator muscle" EXACT [Wikipedia:Iris_dilator_muscle] +synonym: "pupillary muscle" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "radial muscle" RELATED [Wikipedia:Iris_dilator_muscle] +synonym: "radial muscle of iris" EXACT [Wikipedia:Iris_dilator_muscle] +synonym: "radiating fibers" RELATED [Wikipedia:Iris_dilator_muscle] +xref: BTO:0001371 +xref: EMAPA:35286 +xref: FMA:49158 +xref: MA:0001288 +xref: NCIT:C32463 +xref: SCTID:280890008 +xref: UMLS:C0229190 {source="ncithesaurus:Dilator_Pupillae_Muscle"} +xref: Wikipedia:Iris_dilator_muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle +relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm +relationship: has_muscle_antagonist UBERON:0001607 {source="dbpedia"} ! sphincter pupillae +relationship: has_muscle_insertion UBERON:0001769 {notes="inner margins of iris", source="dbpedia"} ! iris +relationship: has_muscle_origin UBERON:0001769 {notes="outer margins of iris", source="dbpedia"} ! iris +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png xsd:anyURI +property_value: UBPROP:0000009 "It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on alpha1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina" xsd:string + [Term] id: UBERON:0001610 name: lingual artery namespace: uberon def: "The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP]." [Wikipedia:Lingual_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria lingualis" RELATED LATIN [Wikipedia:Lingual_artery] synonym: "lingual branch of external carotid artery" EXACT [] @@ -220214,15 +324407,28 @@ intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0001723 ! tongue relationship: in_lateral_side_of UBERON:0001723 {source="FMA-abduced-lr"} ! tongue relationship: supplies UBERON:0001723 ! tongue -property_value: depicted:by Lingual:artery.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Part of the external carotid which supplies blood to the tongue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010492", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship loss: part_of external carotid (AAO:0010218)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010492", ontology="AAO"} +[Term] +id: UBERON:0001611 +name: sublingual artery +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0004573 ! systemic artery +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001832 ! sublingual gland +relationship: branching_part_of UBERON:0001610 ! lingual artery +relationship: supplies UBERON:0001832 ! sublingual gland + [Term] id: UBERON:0001612 name: facial artery namespace: uberon def: "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." [Wikipedia:Facial_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria maxillaris externa" RELATED LATIN [Wikipedia:Facial_artery] synonym: "external maxillary artery" RELATED [] @@ -220240,12 +324446,14 @@ intersection_of: branching_part_of UBERON:0001070 ! external carotid artery intersection_of: supplies UBERON:0001456 ! face relationship: supplies UBERON:0001456 ! face property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001616 name: maxillary artery namespace: uberon def: "An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]." [Wikipedia:Maxillary_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria maxillaris" RELATED LATIN [Wikipedia:Maxillary_artery] synonym: "internal maxillary artery" RELATED [] @@ -220265,8 +324473,10 @@ is_a: UBERON:0001637 ! artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001637 ! artery intersection_of: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1 +relationship: connected_to UBERON:0001070 ! external carotid artery relationship: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1 property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries" xsd:string {source="http://download.videohelp.com/vitualis/med/Vascular_Devt.html"} [Term] @@ -220274,6 +324484,7 @@ id: UBERON:0001619 name: ophthalmic artery namespace: uberon def: "The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified]." [Wikipedia:Ophthalmic_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria ophthalmica" RELATED LATIN [Wikipedia:Ophthalmic_artery] synonym: "opthalmic artery" RELATED [Wikipedia:Ophthalmic_artery] @@ -220294,7 +324505,9 @@ xref: XAO:0000368 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004573 ! systemic artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: branching_part_of UBERON:0001532 ! internal carotid artery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Part of internal carotid which carries blood via branches to the eye, the eye muscles, and eyelids.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010497", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship loss: part_of internal carotid (AAO:0010219)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010497", ontology="AAO"} @@ -220303,6 +324516,7 @@ id: UBERON:0001620 name: central retinal artery namespace: uberon def: "The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted]." [Wikipedia:Central_retinal_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria centralis retinae" RELATED [Wikipedia:Central_retinal_artery] synonym: "arteria centralis retinae" RELATED LATIN [Wikipedia:Central_retinal_artery] @@ -220321,7 +324535,10 @@ xref: UMLS:C0035301 {source="ncithesaurus:Retinal_Artery"} xref: Wikipedia:Central_retinal_artery is_a: UBERON:0003501 ! retina blood vessel is_a: UBERON:0004573 ! systemic artery -property_value: depicted:by Gray514:updated.png xsd:anyURI +relationship: branching_part_of UBERON:0001619 ! ophthalmic artery +relationship: supplies UBERON:0000966 ! retina +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/59/Gray514_updated.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001621 @@ -220350,6 +324567,7 @@ xref: Wikipedia:Coronary_circulation#Coronary_anatomy xref: ZFA:0005812 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0004573 ! systemic artery +relationship: supplies UBERON:0002349 ! myocardium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png xsd:anyURI [Term] @@ -220357,6 +324575,7 @@ id: UBERON:0001622 name: lacrimal artery namespace: uberon def: "The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted]." [Wikipedia:Lacrimal_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "a. lacrimalis" RELATED LATIN [Wikipedia:Lacrimal_artery] xref: EMAPA:37094 {source="MA:th"} @@ -220369,13 +324588,19 @@ xref: Wikipedia:Lacrimal_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004573 ! systemic artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001817 ! lacrimal gland +relationship: branching_part_of UBERON:0001619 ! ophthalmic artery +relationship: supplies UBERON:0001817 ! lacrimal gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001623 name: dorsal nasal artery namespace: uberon def: "The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted]." [Wikipedia:Dorsal_nasal_artery] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria dorsalis nasi" RELATED LATIN [Wikipedia:Dorsal_nasal_artery] synonym: "dorsal nasal branch of ophthalmic artery" EXACT [FMA:50000] @@ -220389,12 +324614,14 @@ xref: UMLS:C0226194 {source="ncithesaurus:Dorsal_Nasal_Artery"} xref: Wikipedia:Dorsal_nasal_artery is_a: UBERON:0015156 {source="FMA"} ! terminal branch of ophthalmic artery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/35/Gray515.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001628 name: posterior communicating artery namespace: uberon def: "One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery." [Wikipedia:Posterior_communicating_artery] +subset: human_reference_atlas subset: uberon_slim subset: vertebrate_core synonym: "arteria cerebri communicans posterior" RELATED LATIN [Wikipedia:Posterior_communicating_artery] @@ -220427,6 +324654,7 @@ relationship: branching_part_of UBERON:0001532 {source="FMA", source="ZFA"} ! in relationship: in_lateral_side_of UBERON:0003709 {source="FMA-abduced-lr"} ! circle of Willis relationship: part_of UBERON:0003709 ! circle of Willis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery. Isogai et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005001", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "todo - verify ZFA link: An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery" xsd:string @@ -220445,13 +324673,19 @@ xref: EMAPA:19211 xref: FMA:50095 xref: GAID:813 xref: MA:0002463 -xref: MESH:A08.800.550.700.120.600.150 +xref: MESH:D002344 xref: NCIT:C66852 xref: SCTID:362586000 xref: UMLS:C0007277 {source="ncithesaurus:Carotid_Body"} xref: Wikipedia:Carotid_body is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034979 ! nonchromaffin paraganglion +relationship: capable_of_part_of GO:0003039 ! detection of reduced oxygen by carotid body chemoreceptor signaling +relationship: has_part CL:0000206 ! chemoreceptor cell +relationship: has_part CL:0002081 ! type II cell of carotid body +relationship: has_part CL:0002292 ! type I cell of carotid body +relationship: overlaps UBERON:0001070 ! external carotid artery +relationship: overlaps UBERON:0001532 ! internal carotid artery relationship: part_of UBERON:0001530 ! common carotid artery plus branches property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray1186.png xsd:anyURI @@ -220496,6 +324730,7 @@ id: UBERON:0001631 name: thoracic duct namespace: uberon def: "A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins." [Wikipedia:Thoracic_duct] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220506,7 +324741,7 @@ xref: EMAPA:19310 xref: FMA:5031 xref: GAID:1290 xref: MA:0002801 -xref: MESH:A15.382.520.869 +xref: MESH:D013897 xref: NCIT:C33768 xref: SCTID:362600004 xref: TAO:0005110 @@ -220519,6 +324754,7 @@ relationship: develops_from UBERON:0002065 {source="TAO"} ! posterior cardinal v relationship: develops_from UBERON:0006210 {source="EHDAA2"} ! body-wall mesenchyme property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/75/Gray599.png xsd:anyURI property_value: editor_note "placement of the ZFA class here is dubious" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein." xsd:string {source="FMA:5031"} property_value: UBPROP:0000001 "The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein." xsd:string {source="ZFA:0005110"} @@ -220526,7 +324762,8 @@ property_value: UBPROP:0000001 "The thoracic duct is the first perfused lymphati id: UBERON:0001633 name: basilar artery namespace: uberon -def: "A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain." [BGEE:ann] +def: "A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain." [https://orcid.org/0000-0003-3308-6245] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: unverified_taxonomic_grouping @@ -220551,11 +324788,38 @@ is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0035307 ! branch of vertebral artery relationship: develops_from UBERON:0001535 {source="EHDAA2"} ! vertebral artery relationship: part_of UBERON:0001533 ! subclavian artery +relationship: supplies UBERON:0002028 ! hindbrain property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery that runs along the ventral keel of the hindbrain. It lies between the primordial hindbrain channels(PHBC). It irrigates the hindbrain and is connected, through the hindbrain, to the PHBC by the central arteries." xsd:string {source="ZFA:0005002"} property_value: UBPROP:0000001 "The unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear[MP]." xsd:string {source="MP:0013186"} property_value: UBPROP:0000003 "The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000237", ontology="VHOG", source="DOI:10.1242/dev.058776 Fujita M, Cha YR, Pham VN, Sakurai A, Roman BL, Gutkind JS, Weinstein BM, Assembly and patterning of the vascular network of the vertebrate hindbrain. Development (2011)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0001635 +name: superior cerebellar artery +is_a: UBERON:0003472 ! cerebellar artery +is_a: UBERON:0035489 ! branch of basilar artery +intersection_of: UBERON:0003472 ! cerebellar artery +intersection_of: branching_part_of UBERON:0001633 ! basilar artery +intersection_of: supplies UBERON:0001895 ! metencephalon +intersection_of: supplies UBERON:0001905 ! pineal body +intersection_of: supplies UBERON:0002037 ! cerebellum +relationship: supplies UBERON:0001895 ! metencephalon +relationship: supplies UBERON:0001905 ! pineal body + +[Term] +id: UBERON:0001636 +name: posterior cerebral artery +is_a: UBERON:0004449 ! cerebral artery +is_a: UBERON:0015212 ! lateral structure +is_a: UBERON:0035489 ! branch of basilar artery +intersection_of: UBERON:0004449 ! cerebral artery +intersection_of: branching_part_of UBERON:0001633 ! basilar artery +intersection_of: supplies UBERON:0002021 ! occipital lobe +relationship: in_lateral_side_of UBERON:0001633 ! basilar artery +relationship: supplies UBERON:0002021 ! occipital lobe + [Term] id: UBERON:0001637 name: artery @@ -220605,6 +324869,7 @@ property_value: UBPROP:0000001 "Part of the circulatory system composed of blood property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001251", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001251", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "arterial" xsd:string +property_value: UBPROP:0000012 "Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system." xsd:string property_value: UBPROP:0000202 FMA:63812 [Term] @@ -220669,6 +324934,7 @@ id: UBERON:0001639 name: hepatic portal vein namespace: uberon def: "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." [http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376, ISBN:0073040584, Wikipedia:Hepatic_portal_vein] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220688,8 +324954,12 @@ xref: VHOG:0000642 xref: Wikipedia:Hepatic_portal_vein xref: ZFA:0005090 is_a: UBERON:0002017 {source="MA"} ! portal vein +relationship: channels_into UBERON:0002107 ! liver +relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein +relationship: overlaps UBERON:0002107 ! liver relationship: part_of UBERON:0010194 ! hepatic portal system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000642", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.265", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "In humans A vein in the abdominal cavity that drains blood from the gastrointestinal tract and spleen. It is usually formed by the confluence of the superior mesenteric and splenic veins, and also receives blood from the inferior mesenteric, gastric, and cystic veins. The hepatic portal vein is a major component of the hepatic portal system, one of the main portal venous systems in the body. Conditions involving the hepatic portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the hepatic portal vein. This condition, called portal hypertension, is a major complication of cirrhosis worldwide. [WP,unvetted]" xsd:string @@ -220699,6 +324969,7 @@ name: celiac artery namespace: uberon def: "The first major branch of the abdominal aorta." [Wikipedia:Celiac_artery] comment: dorsal aorta in Kardong +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria coeliaca" RELATED LATIN [Wikipedia:Celiac_artery] @@ -220723,13 +324994,28 @@ xref: SCTID:181340007 xref: UMLS:C0007569 {source="ncithesaurus:Coeliac_Artery"} xref: Wikipedia:Celiac_artery is_a: UBERON:0012254 ! abdominal aorta artery +relationship: develops_from UBERON:0006002 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia"} ! vitelline artery +relationship: indirectly_supplies UBERON:0000160 {source="ISBN:0073040584"} ! intestine +relationship: indirectly_supplies UBERON:0000945 {source="ISBN:0073040584"} ! stomach +relationship: indirectly_supplies UBERON:0002106 {source="ISBN:0073040584"} ! spleen +relationship: indirectly_supplies UBERON:0002107 {source="ISBN:0073040584"} ! liver property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001641 +name: transverse sinus +is_a: UBERON:0017635 ! paired venous dural sinus +intersection_of: UBERON:0017635 ! paired venous dural sinus +intersection_of: tributary_of UBERON:0005475 ! sigmoid sinus +relationship: tributary_of UBERON:0005475 ! sigmoid sinus [Term] id: UBERON:0001643 name: oculomotor nerve namespace: uberon def: "Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles." [ISBN:0471209627, Wikipedia:Oculomotor_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220757,23 +325043,32 @@ xref: EMAPA:17574 xref: FMA:50864 xref: GAID:829 xref: HBA:9316 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=488 {source="BIRNLEX:1646"} xref: MA:0001095 xref: MBA:832 xref: MESH:D009802 xref: NCIT:C12758 +xref: neuronames:488 {source="BIRNLEX:1646"} xref: OpenCyc:Mx4rvj7pZpwpEbGdrcN5Y29ycA xref: SCTID:362456009 xref: TAO:0000405 -xref: UMLS:C0028864 {source="ncithesaurus:Oculomotor_Nerve"} xref: UMLS:C0028864 {source="BIRNLEX:1646"} +xref: UMLS:C0028864 {source="ncithesaurus:Oculomotor_Nerve"} xref: VHOG:0000692 xref: Wikipedia:Oculomotor_nerve xref: XAO:0003090 xref: ZFA:0000405 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve +intersection_of: UBERON:0001785 ! cranial nerve +intersection_of: extends_fibers_into UBERON:0001715 ! oculomotor nuclear complex +intersection_of: innervates UBERON:0001601 ! extra-ocular muscle +intersection_of: innervates UBERON:0011222 ! intra-ocular muscle relationship: develops_from UBERON:0010285 {source="Wikipedia"} ! midbrain basal plate +relationship: extends_fibers_into UBERON:0001715 ! oculomotor nuclear complex +relationship: innervates UBERON:0001601 ! extra-ocular muscle +relationship: innervates UBERON:0011222 ! intra-ocular muscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Somatic efferent fibers which innervate four eye muscles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010468", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000692", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} @@ -220782,6 +325077,7 @@ id: UBERON:0001644 name: trochlear nerve namespace: uberon def: "A cranial nerve that runs to the eye muscles." [ISBN:0471209627, Wikipedia:Trochlear_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220811,11 +325107,11 @@ xref: EMAPA:18218 xref: FMA:50865 xref: GAID:838 xref: HBA:9319 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=466 {source="BIRNLEX:1654"} xref: MA:0001105 xref: MBA:911 xref: MESH:D014321 xref: NCIT:C12808 +xref: neuronames:466 {source="BIRNLEX:1654"} xref: OpenCyc:Mx4rvyeBQ5wpEbGdrcN5Y29ycA xref: SCTID:180939009 xref: TAO:0000600 @@ -220825,8 +325121,15 @@ xref: VHOG:0000705 xref: Wikipedia:Trochlear_nerve xref: XAO:0003091 xref: ZFA:0000600 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve -property_value: depicted:by Trochlear:nerve.png xsd:anyURI +intersection_of: UBERON:0001785 ! cranial nerve +intersection_of: extends_fibers_into UBERON:0002722 ! trochlear nucleus +intersection_of: innervates UBERON:0006321 ! superior oblique extraocular muscle +relationship: extends_fibers_into UBERON:0002722 ! trochlear nucleus +relationship: innervates UBERON:0006321 ! superior oblique extraocular muscle +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/33/Trochlear_nerve.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Somatic efferent nerve which supplies a single eye muscle, the m. obliquus superior.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010469", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000705", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "Homologous trochlear nerves are found in all jawed vertebrates" xsd:string @@ -220838,6 +325141,7 @@ name: trigeminal nerve namespace: uberon def: "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." [ISBN:0471209627, Wikipedia:Trigeminal_nerve] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220868,12 +325172,12 @@ xref: EMAPA:17576 xref: FMA:50866 xref: GAID:726 xref: HBA:9322 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=549 {source="BIRNLEX:869"} xref: MA:0001100 xref: MBA:901 xref: MESH:D014276 xref: MFMO:0000093 xref: NCIT:C12806 +xref: neuronames:549 {source="BIRNLEX:869"} xref: OpenCyc:Mx4rwMF8CJwpEbGdrcN5Y29ycA xref: SCTID:362459002 xref: TAO:0000697 @@ -220883,6 +325187,7 @@ xref: VHOG:0000704 xref: Wikipedia:Trigeminal_nerve xref: XAO:0003092 xref: ZFA:0000697 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus @@ -220894,7 +325199,8 @@ relationship: has_developmental_contribution_from UBERON:0005239 {source="Wikipe relationship: innervates UBERON:0000165 ! mouth relationship: innervates UBERON:0011648 ! jaw muscle relationship: innervates UBERON:1000021 ! skin of face -property_value: depicted:by Gray778:Trigeminal.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010470", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000704", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls" xsd:string {source="ISBN:0471888893"} @@ -220904,6 +325210,7 @@ id: UBERON:0001646 name: abducens nerve namespace: uberon def: "Cranial nerve that runs to the eye muscles." [ISBN:0471209627, Wikipedia:Abducens_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220932,11 +325239,11 @@ xref: EMAPA:18216 xref: FMA:50867 xref: GAID:824 xref: HBA:9325 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=550 {source="BIRNLEX:876"} xref: MA:0001087 xref: MBA:710 xref: MESH:D000010 xref: NCIT:C12665 +xref: neuronames:550 {source="BIRNLEX:876"} xref: OpenCyc:Mx4rvjl41ZwpEbGdrcN5Y29ycA xref: SCTID:180941005 xref: TAO:0000310 @@ -220946,9 +325253,17 @@ xref: VHOG:0000697 xref: Wikipedia:Abducens_nerve xref: XAO:0003093 xref: ZFA:0000310 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve +intersection_of: UBERON:0001785 ! cranial nerve +intersection_of: extends_fibers_into UBERON:0002682 ! abducens nucleus +intersection_of: innervates UBERON:0001601 ! extra-ocular muscle relationship: develops_from UBERON:0005239 {source="Wikipedia"} ! basal plate metencephalon -property_value: depicted:by Abducens:nerve1.png xsd:anyURI +relationship: extends_fibers_into UBERON:0002682 ! abducens nucleus +relationship: innervates UBERON:0001601 ! extra-ocular muscle +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/29/Abducens_nerve1.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Somatic motor nerve which bifurcates innervating m. rectus lateralis and m. retractor bulbi (eye muscles).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010471", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000697", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "Homologous abducens nerves are found in all vertebrates except lampreys and hagfishes.[WP] It controls the movement of a single muscle, the lateral rectus muscle of the eye, in humans. In most other mammals it also innervates the musculus retractor bulbi, which can retract the eye for protection" xsd:string {source="WP"} @@ -220958,6 +325273,7 @@ id: UBERON:0001647 name: facial nerve namespace: uberon def: "Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches)." [ISBN:0471209627, Wikipedia:Facial_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -220991,11 +325307,11 @@ xref: EMAPA:17796 xref: FMA:50868 xref: GAID:719 xref: HBA:9328 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=551 {source="BIRNLEX:827"} xref: MA:0001091 xref: MBA:798 xref: MESH:D005154 xref: NCIT:C12714 +xref: neuronames:551 {source="BIRNLEX:827"} xref: OpenCyc:Mx4rvthgEpwpEbGdrcN5Y29ycA xref: SCTID:362460007 xref: TAO:0000664 @@ -221005,9 +325321,18 @@ xref: VHOG:0000706 xref: Wikipedia:Facial_nerve xref: XAO:0003094 xref: ZFA:0000664 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: extends_fibers_into UBERON:0000127 ! facial nucleus +intersection_of: innervates UBERON:0001577 ! facial muscle +relationship: extends_fibers_into UBERON:0000127 ! facial nucleus +relationship: has_developmental_contribution_from UBERON:0003066 ! pharyngeal arch 2 +relationship: has_developmental_contribution_from UBERON:0005239 ! basal plate metencephalon +relationship: innervates UBERON:0001577 ! facial muscle relationship: part_of UBERON:0001033 {source="ZFA"} ! gustatory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1f/Cranial_nerve_VII.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Slender nerve composed of branchiomotor and visceral efferent fibers innervating the mouth and various muscles within the jaw. Sensory components innervate the bucccal roof and somatomotor components innervate the depressor musculature and muscle interhyoideus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010472", ontology="AAO", source="AAO:DSM"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000706", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} @@ -221016,6 +325341,7 @@ id: UBERON:0001648 name: vestibulocochlear nerve namespace: uberon def: "Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain." [ISBN:0471209627, Wikipedia:Vestibulocochlear_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -221051,11 +325377,11 @@ xref: EMAPA:17801 xref: FMA:50869 xref: GAID:839 xref: HBA:9331 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=553 {source="BIRNLEX:890"} xref: MA:0001109 xref: MBA:933 xref: MESH:D000159 xref: NCIT:C12996 +xref: neuronames:553 {source="BIRNLEX:890"} xref: OpenCyc:Mx4rvVjMFZwpEbGdrcN5Y29ycA xref: SCTID:180945001 xref: TAO:0000247 @@ -221066,10 +325392,17 @@ xref: VHOG:0000695 xref: Wikipedia:Vestibulocochlear_nerve xref: XAO:0003095 xref: ZFA:0000247 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve +intersection_of: UBERON:0001785 ! cranial nerve +intersection_of: extends_fibers_into UBERON:0001720 ! cochlear nucleus +intersection_of: innervates UBERON:0001844 ! cochlea relationship: develops_from UBERON:0003069 {source="ISBN:0471888893"} ! otic placode +relationship: extends_fibers_into UBERON:0001720 ! cochlear nucleus +relationship: innervates UBERON:0001844 ! cochlea relationship: part_of UBERON:0002105 ! vestibulo-auditory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nerve primarily composed of special somatic afferent fibers innervating the inner ear, and is involved in balance, position, and hearing.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010473", ontology="AAO", source="AAO:DSM"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000695", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} @@ -221078,6 +325411,7 @@ id: UBERON:0001649 name: glossopharyngeal nerve namespace: uberon def: "Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult)." [ISBN:0471209627, Wikipedia:Glossopharyngeal_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -221104,21 +325438,22 @@ xref: EMAPA:17268 xref: FMA:50870 xref: GAID:827 xref: HBA:9334 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=701 {source="BIRNLEX:899"} xref: MA:0001093 xref: MBA:808 xref: MESH:D005930 xref: NCIT:C12723 +xref: neuronames:701 {source="BIRNLEX:899"} xref: OpenCyc:Mx4rwIr5X5wpEbGdrcN5Y29ycA xref: SCTID:362465002 xref: TAO:0000668 -xref: UMLS:C0017679 {source="ncithesaurus:Glossopharyngeal_Nerve"} xref: UMLS:C0017679 {source="BIRNLEX:899"} +xref: UMLS:C0017679 {source="ncithesaurus:Glossopharyngeal_Nerve"} xref: UMLS:C1305752 {source="BIRNLEX:899"} xref: VHOG:0000701 xref: Wikipedia:Glossopharyngeal_nerve xref: XAO:0003096 xref: ZFA:0000668 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve relationship: extends_fibers_into UBERON:0001896 ! medulla oblongata relationship: has_developmental_contribution_from UBERON:0005239 {notes="motor", source="Wikipedia"} ! basal plate metencephalon @@ -221126,6 +325461,7 @@ relationship: innervates UBERON:0001727 ! taste bud relationship: innervates UBERON:0006562 ! pharynx relationship: part_of UBERON:0001033 ! gustatory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Small nerve consisting of branchiomotor and visceral efferent and afferent fibers which innervate the m. subarculais rectus I, dorsal buccal mucosa, and the tongue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010474", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000701", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} @@ -221134,6 +325470,7 @@ id: UBERON:0001650 name: hypoglossal nerve namespace: uberon def: "Cranial nerve that innervates the muscles of the tongue." [http://orcid.org/0000-0002-6601-2165, ISBN:080184780X, VHOG:0000693] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "12n" BROAD ABBREVIATION [BIRNLEX:820, NIFSTD:NeuroNames_abbrevSource] @@ -221161,11 +325498,11 @@ xref: EMAPA:17269 xref: FMA:50871 xref: GAID:828 xref: HBA:9343 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=704 {source="BIRNLEX:820"} xref: MA:0001094 xref: MBA:813 xref: MESH:D007002 xref: NCIT:C12732 +xref: neuronames:704 {source="BIRNLEX:820"} xref: OpenCyc:Mx4rv9eWA5wpEbGdrcN5Y29ycA xref: SCTID:362471008 xref: UMLS:C0020614 {source="BIRNLEX:820"} @@ -221173,6 +325510,7 @@ xref: UMLS:C0020614 {source="ncithesaurus:Hypoglossal_Nerve"} xref: VHOG:0000693 xref: Wikipedia:Hypoglossal_nerve xref: XAO:0004215 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002871 ! hypoglossal nucleus @@ -221183,6 +325521,7 @@ relationship: innervates UBERON:0001572 ! hyoglossus muscle relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray794.png xsd:anyURI property_value: RO:0002174 NCBITaxon:8292 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Cranial nerve that innervates muscles in the tongue. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-14, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000693", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "In amphibians, represents the hypoglossal nerve in amniotes. Innverates mm. geniohyoideus, genioglossus, hyoglossus, rectus cervicis" xsd:string {source="ISBN:080184780X"} property_value: UBPROP:0000001 "Nerve which innervates the muscles associated with the tongue including mm geniohyoideus, genioglossus, hyoglossus and rectus cervicis.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010477", ontology="AAO", source="AAO:EJS"} @@ -221194,6 +325533,7 @@ id: UBERON:0001651 name: right pulmonary artery namespace: uberon def: "The pulmonary artery that supplies the right lung." [UBERON:cjm] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria pulmonalis dextra" RELATED LATIN [Wikipedia:Right_pulmonary_artery] synonym: "right main pulmonary artery" EXACT [] @@ -221209,16 +325549,19 @@ xref: Wikipedia:Right_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0002167 ! right lung +relationship: connected_to UBERON:0002333 ! pulmonary trunk relationship: supplies UBERON:0002167 ! right lung -property_value: depicted:by Alveoli:diagram.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001652 name: left pulmonary artery namespace: uberon def: "The pulmonary artery that supplies the left lung." [UBERON:cjm] +subset: human_reference_atlas subset: uberon_slim synonym: "arteria pulmonalis sinistra" RELATED LATIN [Wikipedia:Left_pulmonary_artery] synonym: "left main pulmonary artery" EXACT [] @@ -221234,10 +325577,12 @@ xref: Wikipedia:Left_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0002168 ! left lung +relationship: connected_to UBERON:0002333 ! pulmonary trunk relationship: supplies UBERON:0002168 ! left lung -property_value: depicted:by Alveoli:diagram.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001653 @@ -221245,6 +325590,7 @@ name: facial vein namespace: uberon def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [http://en.wikipedia.org/wiki/Facial_vein] def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [Wikipedia:Facial_vein] +subset: human_reference_atlas subset: uberon_slim synonym: "anterior facial vein" RELATED INCONSISTENT [Wikipedia:Facial_vein] synonym: "anterior facial vein" RELATED INCONSISTENT [http://en.wikipedia.org/wiki/Facial_vein] @@ -221271,6 +325617,7 @@ relationship: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001586 ! internal jugular vein relationship: tributary_of UBERON:0001586 {source="FMA"} ! internal jugular vein property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010513", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000012 "MA and NCITA also has 'anterior facial vein'" xsd:string {external_ontology="MA"} @@ -221319,10 +325666,22 @@ xref: MA:0002400 xref: NCIT:C53181 xref: UMLS:C0224458 {source="ncithesaurus:Triceps_Surae"} xref: Wikipedia:Triceps_surae_muscle +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004256 ! hindlimb zeugopod muscle +relationship: has_muscle_insertion UBERON:0001450 ! calcaneus +relationship: has_muscle_insertion UBERON:0003701 ! calcaneal tendon +relationship: innervated_by UBERON:0001323 ! tibial nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/57/Illu_lower_extremity_muscles.jpg xsd:anyURI property_value: UBPROP:0000012 "A set of muscles in FMA, a single organ in MA" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0001668 +name: cerebellar vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002037 ! cerebellum +relationship: drains UBERON:0002037 ! cerebellum + [Term] id: UBERON:0001675 name: trigeminal ganglion @@ -221358,11 +325717,11 @@ xref: EHDAA:2113 xref: EMAPA:16797 xref: FMA:52618 xref: GAID:725 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1402 xref: MA:0001080 xref: MAT:0000511 xref: MESH:D012668 xref: NCIT:C62642 +xref: neuronames:1402 xref: SCTID:244449009 xref: TAO:0000295 xref: UMLS:C0040995 {source="ncithesaurus:Trigeminal_Ganglion"} @@ -221452,7 +325811,12 @@ is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0008193 {source="FMA"} ! pneumatized bone is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0009193 {source="cjm"} ! sphenoid cartilage element +relationship: overlaps UBERON:0002241 ! chondrocranium +relationship: overlaps UBERON:0003113 ! dermatocranium +relationship: overlaps UBERON:0008895 ! splanchnocranium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg xsd:anyURI property_value: UBPROP:0000012 "part of viscerocranium (facial skeleton) in FMA" xsd:string {external_ontology="FMA"} @@ -221512,6 +325876,7 @@ xref: Wikipedia:Ethmoid_bone is_a: UBERON:0002513 {source="ISBN:0073040584"} ! endochondral bone is_a: UBERON:0003462 ! facial bone is_a: UBERON:0011164 ! neurocranium bone +relationship: contributes_to_morphology_of UBERON:0011156 ! facial skeleton relationship: develops_from UBERON:0006227 {evidence="definitional"} ! ethmoid bone primordium relationship: part_of UBERON:0002517 ! basicranium relationship: part_of UBERON:0011241 ! ethmoid region @@ -221530,7 +325895,7 @@ def: "The irregularly thin plate that forms part of the medial wall of the orbit subset: pheno_slim subset: uberon_slim subset: vertebrate_core -synonym: "infraorbital 1" RELATED SENSU [TODO:TODO, VHOG:0001149, ZFA:0000223] +synonym: "infraorbital 1" RELATED SENSU [VHOG:0001149, ZFA:0000223] synonym: "lachrymal bone" EXACT [] synonym: "lachrymal bone - infraorbital 1" RELATED [VHOG:0001149] synonym: "lacrimal" BROAD [] @@ -221703,6 +326068,7 @@ xref: UMLS:C0024687 {source="ncithesaurus:Mandible"} xref: Wikipedia:Human_mandible is_a: UBERON:0002514 {source="EHDAA2"} ! intramembranous bone is_a: UBERON:0004742 ! dentary +relationship: contributes_to_morphology_of UBERON:0001708 ! jaw skeleton property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png xsd:anyURI property_value: editor_note "consider merging with dentary - for now we make it a mammal-specific subclass." xsd:string property_value: UBPROP:0000007 "mandibular" xsd:string @@ -221776,6 +326142,8 @@ xref: Wikipedia:Auditory_ossicle xref: XAO:0000214 is_a: UBERON:0003457 ! head bone is_a: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b0/Illu_auditory_ossicles.jpg xsd:anyURI property_value: editor_note "This should probably be restricted to mammals - the AAO/XAO structures may group non-homologous structures [Wikipedia:Evolution_of_mammalian_auditory_ossicles] see https://github.com/seger/aao/issues/5." xsd:string property_value: UBPROP:0000001 "The small bones of the middle ear: incus, malleus, and stapes. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000461", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/auditory+ossicles"} @@ -221917,6 +326285,7 @@ xref: Wikipedia:Ear xref: XAO:0000189 is_a: UBERON:0000020 ! sense organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound relationship: part_of UBERON:0000033 ! head relationship: part_of UBERON:0002105 ! vestibulo-auditory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b8/Ear.jpg xsd:anyURI @@ -221961,6 +326330,10 @@ xref: Wikipedia:External_ear xref: XAO:0000190 is_a: UBERON:0001444 ! subdivision of head is_a: UBERON:0015212 ! lateral structure +relationship: contributes_to_morphology_of UBERON:0000033 ! head +relationship: contributes_to_morphology_of UBERON:0001690 ! ear +relationship: in_lateral_side_of UBERON:0000033 ! head +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of UBERON:0001690 ! ear property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/29/Gray907.png xsd:anyURI property_value: RO:0002161 NCBITaxon:9709 {source="Wikipedia"} @@ -222142,6 +326515,8 @@ xref: ZFA:0001410 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton is_a: UBERON:0015212 ! lateral structure +relationship: in_lateral_side_of UBERON:0011156 ! facial skeleton +relationship: location_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0004088 ! orbital region relationship: part_of UBERON:0011156 ! facial skeleton property_value: UBPROP:0000001 "Anatomical cluster that is a anterolateral part of the cranium and structurally supports the eye.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001410", ontology="TAO", source="TAO:MAH"} @@ -222176,10 +326551,10 @@ xref: EHDAA:6644 xref: EMAPA:17569 xref: FMA:53414 xref: GAID:718 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1535 xref: MA:0001076 xref: MESH:D005830 xref: NCIT:C12721 +xref: neuronames:1535 xref: SCTID:279076005 xref: TAO:0001291 xref: UMLS:C0017406 {source="ncithesaurus:Geniculate_Ganglion"} @@ -222189,9 +326564,12 @@ xref: ZFA:0001291 is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion is_a: UBERON:0009127 ! epibranchial ganglion is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001714 ! cranial ganglion +intersection_of: extends_fibers_into UBERON:0001647 ! facial nerve relationship: develops_from UBERON:0009124 {source="EHDAA2:0004623", source="ZFA"} ! geniculate placode relationship: develops_from UBERON:0010258 {source="EHDAA2:0004623"} ! mesenchyme from rhombencephalic neural crest relationship: develops_from UBERON:0012175 {source="EHDAA2:0000491"} ! acoustico-facial VII-VIII ganglion complex +relationship: extends_fibers_into UBERON:0001647 ! facial nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png xsd:anyURI property_value: editor_note "resolve facial VII vs geniculate (see EHDAA2)" xsd:string property_value: UBPROP:0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000707", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} @@ -222321,6 +326699,7 @@ xref: UMLS:C0027342 {source="ncithesaurus:Nail"} xref: VHOG:0001361 xref: Wikipedia:Nail_(anatomy) is_a: UBERON:0009564 ! distal limb integumentary appendage +relationship: composed_primarily_of GO:0045095 ! keratin filament property_value: IAO:0000232 "Use this class for both the nails of primates and the homologous claws of mammals such as mouse." xsd:string property_value: UBPROP:0000008 "A primate's nail consists of the unguis alone; the subunguis has disappeared" xsd:string @@ -222345,7 +326724,7 @@ xref: EMAPA:17608 xref: FMA:54375 xref: GAID:115 xref: MA:0000285 -xref: MESH:A02.165.639 +xref: MESH:D009300 xref: NCIT:C33160 xref: OpenCyc:Mx4rv7e-k5wpEbGdrcN5Y29ycA xref: SCTID:181197004 @@ -222449,7 +326828,7 @@ xref: TAO:0001227 xref: UMLS:C0022359 {source="ncithesaurus:Jaw"} xref: Wikipedia:Jaw xref: ZFA:0001227 -is_a: BFO:0000040 ! material entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -222490,8 +326869,13 @@ xref: ncithesaurus:Upper_Jaw xref: SCTID:362636001 xref: VHOG:0000454 xref: Wikipedia:Upper_jaw +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000475 ! organism subdivision +intersection_of: has_skeleton UBERON:0003277 ! skeleton of upper jaw +disjoint_from: UBERON:0001710 ! lower jaw region +relationship: has_skeleton UBERON:0003277 ! skeleton of upper jaw relationship: part_of UBERON:0004089 ! midface relationship: part_of UBERON:0011595 ! jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png xsd:anyURI @@ -222526,6 +326910,7 @@ xref: ncithesaurus:Lower_Jaw xref: SCTID:362637005 xref: VHOG:0000453 xref: Wikipedia:Lower_jaw +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -222570,8 +326955,11 @@ xref: VHOG:0000016 xref: Wikipedia:Eyelid is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: capable_of GO:0060082 ! eye blink reflex +relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 {source="multiple"} ! camera-type eye -property_value: depicted:by Eye:makeup.jpg xsd:anyURI +relationship: protects UBERON:0010409 ! ocular surface region +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg xsd:anyURI property_value: UBPROP:0000007 "blepharic" xsd:string property_value: UBPROP:0000007 "palpebral" xsd:string property_value: UBPROP:0000008 "In humans the upper and lower eyelid consists of the following layers, starting anteriorly: (1) skin, (2) a layer of subcutaneous connective tissue, (3) a layer of striated muscle fibres of the orbicularis muscle, (4) a layer of submuscular connective tissue, (5) a fibrous layer, including the tarsal plates, (6) a layer of smooth muscle, (7) the palpebral conjunctiva." xsd:string @@ -222598,7 +326986,7 @@ xref: SCTID:244499008 xref: UMLS:C0585636 {source="ncithesaurus:Upper_Eyelid"} xref: VHOG:0000389 is_a: UBERON:0001711 ! eyelid -property_value: depicted:by Eye:makeup.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg xsd:anyURI property_value: UBPROP:0000003 "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000389", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.431", source="http://bgee.unil.ch/"} [Term] @@ -222622,7 +327010,7 @@ xref: UMLS:C0229258 {source="ncithesaurus:Lower_Eyelid"} xref: VHOG:0000388 xref: XAO:0000007 is_a: UBERON:0001711 ! eyelid -property_value: depicted:by Eye:makeup.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg xsd:anyURI property_value: UBPROP:0000003 "A tetrapod's eye usually has one or more eyelids that can move across its surface and protect and cleanse it. The eye of lissamphibians has a stationary upper eyelid but a movable and transparent lower one.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000388", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.431", source="http://bgee.unil.ch/"} [Term] @@ -222703,10 +327091,11 @@ xref: EMAPA:35605 xref: EV:0100250 xref: FMA:54510 xref: HBA:9030 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=492 {source="BIRNLEX:1240"} xref: MA:0001073 xref: MBA:35 +xref: MESH:D065838 xref: NCIT:C12897 +xref: neuronames:492 {source="BIRNLEX:1240"} xref: SCTID:362457000 xref: TAO:0000553 xref: UMLS:C0228686 {source="ncithesaurus:Oculomotor_Nucleus"} @@ -222762,7 +327151,10 @@ xref: UMLS:C1519217 {source="ncithesaurus:Secondary_Palate"} xref: Wikipedia:Secondary_palate is_a: UBERON:0007375 ! roof of mouth is_a: UBERON:0010313 ! neural crest-derived structure +relationship: adjacent_to UBERON:0000167 ! oral cavity +relationship: adjacent_to UBERON:0001707 ! nasal cavity relationship: develops_from UBERON:0005619 {notes="fusion", source="http://www.indiana.edu/~anat550/hnanim/face/face.html"} ! secondary palatal shelf +relationship: only_in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0001709 {source="EMAPA"} ! upper jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Pig_snout_sagittal_cut.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg xsd:anyURI @@ -222804,9 +327196,9 @@ xref: EMAPA:35881 xref: EV:0100252 xref: FMA:54568 xref: HBA:9205 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=558 {source="BIRNLEX:1010"} xref: MA:0001057 xref: MBA:460 +xref: neuronames:558 {source="BIRNLEX:1010"} xref: SCTID:369032001 xref: TAO:0000312 xref: UMLS:C0228702 {source="BIRNLEX:1010"} @@ -222847,6 +327239,10 @@ xref: TAO:0002243 xref: Wikipedia:Cochlear_nucleus xref: ZFA:0001638 is_a: UBERON:0007635 ! nucleus of medulla oblongata +intersection_of: UBERON:0000125 ! neural nucleus +intersection_of: part_of UBERON:0002610 ! cochlear nuclear complex +relationship: contributes_to_morphology_of UBERON:0002298 ! brainstem +relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve relationship: part_of UBERON:0002610 ! cochlear nuclear complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png xsd:anyURI @@ -222927,9 +327323,27 @@ xref: UMLS:C0037885 {source="ncithesaurus:Sphenoid_Sinus"} xref: Wikipedia:Sphenoidal_sinus is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001825 ! paranasal sinus +intersection_of: UBERON:0001825 ! paranasal sinus +intersection_of: part_of UBERON:0009639 ! body of sphenoid +relationship: in_lateral_side_of UBERON:0003129 ! skull +relationship: in_lateral_side_of UBERON:0009639 ! body of sphenoid relationship: part_of UBERON:0009639 ! body of sphenoid property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray856.png xsd:anyURI +[Term] +id: UBERON:0001725 +name: cranial synchondrosis +namespace: uberon +def: "The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis." [http://www.medilexicon.com/medicaldictionary.php?t=87514] +xref: EMAPA:35264 +xref: FMA:54816 +xref: MA:0001502 +xref: SCTID:314228003 +is_a: UBERON:0002215 {source="FMA"} ! synchondrosis +intersection_of: UBERON:0002215 ! synchondrosis +intersection_of: part_of UBERON:0003129 ! skull +relationship: part_of UBERON:0003129 ! skull + [Term] id: UBERON:0001726 name: papilla of tongue @@ -222974,7 +327388,7 @@ xref: FMA:54825 xref: GAID:815 xref: http://uri.neuinfo.org/nif/nifstd/nifext_14 xref: MA:0001591 -xref: MESH:A08.800.550.700.120.800 +xref: MESH:D013650 xref: NCIT:C96518 xref: OpenCyc:Mx4rvVjan5wpEbGdrcN5Y29ycA xref: SCTID:362099006 @@ -223023,7 +327437,7 @@ xref: FMA:54878 xref: GAID:339 xref: MA:0000443 xref: MAT:0000447 -xref: MESH:A03.867.557 +xref: MESH:D009305 xref: NCIT:C12423 xref: OpenCyc:Mx4rwUPoDJwpEbGdrcN5Y29ycA xref: SCTID:181200003 @@ -223031,9 +327445,10 @@ xref: UMLS:C0027442 {source="ncithesaurus:Nasopharynx"} xref: VHOG:0000375 xref: Wikipedia:Nasopharynx is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract +relationship: contributes_to_morphology_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001557 ! upper respiratory tract -property_value: depicted:by Illu:pharynx.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg xsd:anyURI property_value: UBPROP:0000001 "The uppermost of the three regions of the throat (pharynx), situated behind the nasal cavity and extending from the posterior nares to the level above the soft palate. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000375", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/nasopharynx"} property_value: UBPROP:0000007 "nasopharyngeal" xsd:string property_value: UBPROP:0000008 "In humans - in front it communicates through the choanae with the nasal cavities. On its lateral wall is the pharyngeal ostium of the auditory tube, somewhat triangular in shape, and bounded behind by a firm prominence, the torus tubarius or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane" xsd:string @@ -223059,7 +327474,7 @@ xref: FMA:54879 xref: GAID:340 xref: MA:0000351 xref: MAT:0000446 -xref: MESH:A03.867.603 +xref: MESH:D009960 xref: NCIT:C12762 xref: OpenCyc:Mx4rwACoxpwpEbGdrcN5Y29ycA xref: SCTID:263376008 @@ -223070,10 +327485,11 @@ xref: Wikipedia:Oropharynx xref: XAO:0004048 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube +relationship: contributes_to_morphology_of UBERON:0001042 ! chordate pharynx relationship: develops_from UBERON:0010023 {source="ISBN:0073040584-table13.1"} ! dorsal part of pharyngeal pouch 2 relationship: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system -property_value: depicted:by Illu:pharynx.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg xsd:anyURI property_value: UBPROP:0000001 "One of the three anatomic divisions of the pharynx that lies posterior to the mouth and is continuous above with the nasopharynx and below with the laryngopharynx. It extends behind the mouth from the soft palate above to the level of the hyoid bone below and contains the palatine and lingual tonsils. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000457", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/oropharynx"} property_value: UBPROP:0000007 "oropharyngeal" xsd:string @@ -223124,7 +327540,7 @@ xref: EV:0100054 xref: FMA:54970 xref: GAID:1288 xref: MA:0000774 -xref: MESH:A15.382.520.604.084 +xref: MESH:D000234 xref: NCIT:C33318 xref: SCTID:181199001 xref: UMLS:C0001428 {source="ncithesaurus:Pharyngeal_Tonsil"} @@ -223159,7 +327575,7 @@ xref: Wikipedia:Soft_palate is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000477 {source="FMA"} ! anatomical cluster relationship: part_of UBERON:0001716 {source="MA"} ! secondary palate -property_value: depicted:by Tonsils:diagram.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg xsd:anyURI property_value: RO:0002161 NCBITaxon:8782 {source="GOC:fmc"} property_value: UBPROP:0000001 "A muscular arch-shaped structure that is composed of the musculus uvuli and parts of tensor veli palatini, levator veli palatini, palatoglossus and palatopharyngeus and attaches to the hard palate and modulates the connections between the oral cavity and pharynx soft tissue arch .[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} property_value: UBPROP:0000007 "velar" xsd:string @@ -223189,8 +327605,10 @@ xref: UMLS:C0042173 {source="ncithesaurus:Uvula"} xref: Wikipedia:Palatine_uvula is_a: UBERON:0004529 ! anatomical projection is_a: UBERON:0010313 ! neural crest-derived structure +relationship: capable_of_part_of GO:0071625 ! vocalization behavior +relationship: only_in_taxon NCBITaxon:9443 ! Primates relationship: part_of UBERON:0001733 ! soft palate -property_value: depicted:by Tonsils:diagram.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg xsd:anyURI property_value: UBPROP:0000008 "In a study of eight mammals a small underdeveloped uvula was found only in baboons" xsd:string {source="PMID:1408233"} [Term] @@ -223248,6 +327666,8 @@ xref: Wikipedia:Submandibular_gland is_a: UBERON:0001829 ! major salivary gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0006298 ! submandibular gland primordium +relationship: in_lateral_side_of UBERON:0001710 ! lower jaw region +relationship: only_in_taxon NCBITaxon:32524 ! Amniota property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg xsd:anyURI property_value: UBPROP:0000001 "Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000364", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/submandibular+gland"} property_value: UBPROP:0000003 "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000364", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.525", source="http://bgee.unil.ch/"} @@ -223286,6 +327706,7 @@ xref: UMLS:C0023078 {source="ncithesaurus:Larynx"} xref: VHOG:0001279 xref: Wikipedia:Larynx xref: XAO:0003081 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium @@ -223315,7 +327736,7 @@ xref: EMAPA:18698 xref: FMA:55099 xref: GAID:112 xref: MA:0001764 -xref: MESH:A02.165.507.870 +xref: MESH:D013957 xref: NCIT:C33780 xref: SCTID:263483000 xref: UMLS:C0040126 {source="ncithesaurus:Thyroid_Cartilage"} @@ -223342,7 +327763,7 @@ xref: EMAPA:18697 xref: FMA:55108 xref: GAID:107 xref: MA:0001758 -xref: MESH:A02.165.507 +xref: MESH:D007817 xref: NCIT:C12281 xref: SCTID:263482005 xref: UMLS:C0023050 {source="ncithesaurus:Laryngeal_Cartilage"} @@ -223375,7 +327796,7 @@ xref: EMAPA:18695 xref: FMA:55109 xref: GAID:109 xref: MA:0001759 -xref: MESH:A02.165.507.083 +xref: MESH:D001193 xref: NCIT:C32148 xref: SCTID:264446005 xref: UMLS:C0003943 {source="ncithesaurus:Arytenoid_Cartilage"} @@ -223386,6 +327807,35 @@ relationship: develops_from UBERON:0010220 {source="cjm"} ! arytenoid pre-cartil property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray950.png xsd:anyURI property_value: UBPROP:0000001 "Paired, anteroposteriorly elongated cartilages that are associated with the vocal cords. These cartilages are medially separated and hemispherical, and their concave side faces ventromedially.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000674", ontology="AAO", source="AAO:LAP"} +[Term] +id: UBERON:0001742 +name: epiglottic cartilage +is_a: UBERON:0001739 ! laryngeal cartilage +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0001739 ! laryngeal cartilage +intersection_of: part_of UBERON:0000388 ! epiglottis +relationship: composed_primarily_of UBERON:0001996 ! elastic cartilage tissue +relationship: part_of UBERON:0000388 ! epiglottis + +[Term] +id: UBERON:0001743 +name: ligament of larynx +namespace: uberon +def: "A ligament that is part of a larynx and connexts the cartilages of the larynx." [http://education.yahoo.com/reference/gray/subjects/subject/236] +synonym: "laryngeal ligament" EXACT [] +synonym: "larynx ligament" EXACT [MA:0001755] +xref: EMAPA:37626 {source="MA:th"} +xref: FMA:55131 +xref: MA:0001755 +xref: NCIT:C32933 +xref: SCTID:279508004 +xref: UMLS:C0458519 {source="ncithesaurus:Laryngeal_Ligament"} +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0008845 {source="FMA"} ! nonskeletal ligament +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0001737 ! larynx +relationship: part_of UBERON:0001737 ! larynx + [Term] id: UBERON:0001744 name: lymphoid tissue @@ -223406,7 +327856,10 @@ xref: NCIT:C13049 xref: SCTID:181768009 xref: UMLS:C0024296 {source="ncithesaurus:Lymphoid_Tissue"} xref: Wikipedia:Lymphoid_tissue +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034769 {source="FMA"} ! lymphomyeloid tissue +relationship: has_part CL:0000542 ! lymphocyte +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002465 ! lymphoid system property_value: RO:0002174 NCBITaxon:7776 {notes="lampreys lack organized lymphoid tissue", source="NCBIBook:NBK27108"} @@ -223421,11 +327874,28 @@ synonym: "secondary lymphoid nodule" EXACT [] synonym: "secondary lymphoid tissue" EXACT [] xref: FMA:55224 xref: GAID:946 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000444 ! lymphoid follicle relationship: develops_from UBERON:0010422 ! primary nodular lymphoid tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg xsd:anyURI +[Term] +id: UBERON:0001746 +name: capsule of thyroid gland +is_a: UBERON:0003893 ! capsule +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland + +[Term] +id: UBERON:0001747 +name: parenchyma of thyroid gland +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland + [Term] id: UBERON:0001748 name: capsule of parathyroid gland @@ -223439,8 +327909,20 @@ xref: MA:0002676 xref: NCIT:C33265 xref: UMLS:C0927176 {source="ncithesaurus:Parathyroid_Gland_Capsule"} is_a: UBERON:0003893 ! capsule +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0001132 ! parathyroid gland +relationship: bounding_layer_of UBERON:0001132 ! parathyroid gland +relationship: composed_primarily_of UBERON:0011822 ! dense irregular connective tissue relationship: part_of UBERON:0001132 {source="MA"} ! parathyroid gland +[Term] +id: UBERON:0001749 +name: parenchyma of parathyroid gland +is_a: UBERON:0000353 ! parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001132 ! parathyroid gland +relationship: part_of UBERON:0001132 ! parathyroid gland + [Term] id: UBERON:0001750 name: lacrimal apparatus @@ -223468,6 +327950,7 @@ is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region relationship: part_of UBERON:0035639 {source="HPO:pr"} ! ocular adnexa property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png xsd:anyURI @@ -223492,7 +327975,7 @@ xref: EMAPA:35281 xref: FMA:55628 xref: GAID:1272 xref: MA:0002542 -xref: MESH:A14.254.900.280 +xref: MESH:D003804 xref: NCIT:C32453 xref: SCTID:362112004 xref: TAO:0005143 @@ -223504,6 +327987,7 @@ xref: XAO:0004051 xref: ZFA:0005143 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: transformation_of UBERON:0011587 {source="VSAO"} ! pre-dentine property_value: UBPROP:0000001 "Mineralized collagen containing substance that forms the tooth structure.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005143", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Dentine is a bona fide vertebrate novelty, and dentine-secreting odontoblasts represent a cell type that is exclusively derived from the neural crest.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001589", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012)", source="http://bgee.unil.ch/"} @@ -223527,7 +328011,7 @@ xref: CALOHA:TS-1057 xref: EMAPA:35303 xref: FMA:55629 xref: MA:0002543 -xref: MESH:A14.254.900.255 +xref: MESH:D003743 xref: NCIT:C32505 xref: SCTID:362113009 xref: UMLS:C0011350 {source="ncithesaurus:Enamel"} @@ -223536,7 +328020,9 @@ xref: Wikipedia:Enamel_organ xref: XAO:0004198 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue is_a: UBERON:4000013 ! mineralized skeletal tissue +relationship: composed_primarily_of CHEBI:52255 ! hydroxylapatite relationship: develops_from UBERON:0011588 {source="VSAO"} ! pre-enamel +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Enamelorgan11-17-05.jpg xsd:anyURI property_value: editor_note "current classification under substance of tooth may be turned into taxon GCI (e.g. sharks have enamel in dermal denticles)" xsd:string property_value: RO:0002161 NCBITaxon:9359 {source="PMID:19730686"} @@ -223560,7 +328046,7 @@ xref: CALOHA:TS-2163 xref: EMAPA:35203 xref: FMA:55630 xref: MA:0002541 -xref: MESH:A14.254.646.267 +xref: MESH:D003739 xref: NCIT:C32276 xref: SCTID:362114003 xref: UMLS:C0011343 {source="ncithesaurus:Cementum"} @@ -223568,7 +328054,8 @@ xref: VSAO:0000062 xref: Wikipedia:Cementum xref: XAO:0004196 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue -property_value: depicted:by The:Periodontium.jpg xsd:anyURI +relationship: has_developmental_contribution_from UBERON:0008969 ! dental follicle +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg xsd:anyURI property_value: UBPROP:0000001 "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000062", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth[FMA:55630]." xsd:string {source="FMA:55630"} property_value: UBPROP:0000008 "Cementum, the supporting tissue that anchors mammalian and crocodylian teeth into their sockets, differs among species and can have features of dentine, of bone, and of calcified cartilage, as well as unique features. Cementum is deposited by cementoblasts onto existing dentine. As in bone and dentine, cementoblasts produce an organic matrix, the main constituent of which is collagen type I (Bosshardt, 2005), but cementum, dentine, and bone also share a number of important noncollagenous matrix components such as osteopontin, osteocalcin, bone sialoprotein, a2-HS- glycoprotein, dentine matrix protein, dentine sialoprotein, and den- tine phosphoprotein (McKee et al., 1996; Bosshardt, 2005). it has been argued that in all rodents and ruminants, cementum is a form of calcified cartilage[H&W]" xsd:string @@ -223590,7 +328077,7 @@ xref: EMAPA:35274 xref: FMA:55631 xref: GAID:1270 xref: MA:0001599 -xref: MESH:A14.254.900.260 +xref: MESH:D003782 xref: NCIT:C32451 xref: SCTID:362110007 xref: TAO:0005141 @@ -223601,8 +328088,9 @@ xref: ZFA:0005141 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue relationship: develops_from UBERON:0001763 {source="ZFA"} ! odontogenic papilla +relationship: has_part CL:0000060 ! odontoblast relationship: part_of UBERON:0001091 ! calcareous tooth -property_value: depicted:by Tooth:Section.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg xsd:anyURI property_value: UBPROP:0000001 "Material in the center of the dentine of the mature tooth. In secondary teeth the pulp contains blood vessels and odontoblast.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005141", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The oral cavity of vertebrates is generally thought to arise as an ectodermal invagination. Consistent with this, oral teeth are proposed to arise exclusively from ectoderm, contributing to tooth enamel epithelium, and from neural crest derived mesenchyme, contributing to dentin and pulp (reference 1); Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001469", ontology="VHOG", source="DOI:10.1038/nature07304 Soukup V, Epperlein HH, Horacek I, Cerny R, Dual epithelial origin of vertebrate oral teeth. Nature (2008), DOI:10.1186/1471-2148-11-307 The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evolutionary Biology (2011)", source="http://bgee.unil.ch/"} @@ -223639,6 +328127,7 @@ xref: VHOG:0000312 xref: Wikipedia:Middle_ear xref: XAO:0000191 is_a: UBERON:0034921 ! multi organ part structure +relationship: contributes_to_morphology_of UBERON:0001690 ! ear relationship: part_of UBERON:0001690 ! ear property_value: UBPROP:0000001 "The intermediate portion of the ear which consists of a small air-filled and membrane-lined chamber. It is lodged in the temporal bone and continues with the nasopharynx through the Eustachian tube. It is separated from the external ear by the tympanic membrane and from the inner ear by the fenestrae. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000312", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The tympanic cavity and auditory tube of an amniote develop from the first embryonic pharyngeal pouch, so they are homologous to the first gill pouch, or spiracle, of a fish. We are uncertain whether this homology strictly applies to the middle ear cavity and auditory tube of lissamphibians, which show certain peculiarities in their development.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000312", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417", source="http://bgee.unil.ch/"} @@ -223671,7 +328160,10 @@ xref: VHOG:0000460 xref: Wikipedia:Pinna_(anatomy) is_a: UBERON:0001444 ! subdivision of head is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: continuous_with UBERON:0001352 ! external acoustic meatus relationship: develops_from UBERON:0006208 ! auditory hillocks +relationship: has_quality PATO:0001297 ! reflectivity +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0001691 ! external ear property_value: UBPROP:0000001 "The external expanded part of the ear characterized by a funnel-shaped structure through which the sound vibrations are received. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000460", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Mammals have a third type of tympanic ear. An external flap, the auricle or pinna, helps funnel sound waves down the external acoustic meatus to the tympanic membrane.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000460", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.420", source="http://bgee.unil.ch/"} @@ -223691,13 +328183,14 @@ synonym: "tooth supporting structure" RELATED [MESH:A14.254.646] xref: BTO:0001021 xref: CALOHA:TS-2380 xref: GAID:216 -xref: MESH:A14.254.646 +xref: MESH:D010519 xref: NCIT:C33304 xref: UMLS:C0031093 {source="ncithesaurus:Periodontium"} xref: Wikipedia:Periodontium is_a: UBERON:0000479 {source="cjm"} ! tissue +relationship: adjacent_to UBERON:0001091 ! calcareous tooth relationship: part_of UBERON:0003672 {source="cjm"} ! dentition -property_value: depicted:by The:Periodontium.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg xsd:anyURI property_value: UBPROP:0000012 "FMA treats periodontium and periodontal ligament as the same" xsd:string {external_ontology="FMA"} [Term] @@ -223706,6 +328199,7 @@ name: vagus nerve namespace: uberon def: "Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart)." [ISBN:0471209627, Wikipedia:Vagus_nerve] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -223735,11 +328229,11 @@ xref: FMA:5731 xref: GAID:721 xref: galen:VagusNerve xref: HBA:9337 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 {source="BIRNLEX:801"} xref: MA:0001106 xref: MBA:917 xref: MESH:D014630 xref: NCIT:C12812 +xref: neuronames:702 {source="BIRNLEX:801"} xref: OpenCyc:Mx4rviHk2ZwpEbGdrcN5Y29ycA xref: SCTID:362466001 xref: TAO:0000453 @@ -223758,6 +328252,7 @@ relationship: extends_fibers_into UBERON:0011775 ! vagus nerve nucleus relationship: has_developmental_contribution_from UBERON:0005239 {notes="motor", source="Wikipedia"} ! basal plate metencephalon relationship: part_of UBERON:0001033 ! gustatory system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nerve consisting of branchiomotor and visceral efferent fibers which branch and innervate the smooth muscles and glands of the heart, lungs, esophagus, and stomach as well as some throat muscles. Sensory fibers supply mucosa of the mouth and pharynx.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010475", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000737", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"} @@ -223780,7 +328275,7 @@ xref: SCTID:181205008 xref: UMLS:C0016734 {source="ncithesaurus:Frontal_Sinus"} xref: Wikipedia:Frontal_sinus is_a: UBERON:0001825 {source="MA"} ! paranasal sinus -property_value: depicted:by Nnh:front.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg xsd:anyURI property_value: UBPROP:0000008 "A unique feature in the horse is that the frontal sinus communicates with the caudal maxillary sinus via the frontomaxillary opening" xsd:string {source="MURDOCh"} [Term] @@ -223857,7 +328352,7 @@ xref: EMAPA:32892 xref: FMA:57662 xref: GAID:1277 xref: MA:0001598 -xref: MESH:A14.254.900.720.250 +xref: MESH:D003771 xref: TAO:0005140 xref: VHOG:0001465 xref: VSAO:0000025 @@ -223866,7 +328361,12 @@ xref: XAO:0004045 xref: ZFA:0005140 is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0005856 ! developing mesenchymal condensation +intersection_of: composed_primarily_of CL:0007003 ! preodontoblast +intersection_of: part_of UBERON:0008281 ! tooth bud +relationship: composed_primarily_of CL:0007003 ! preodontoblast relationship: develops_from UBERON:0003856 {source="ZFA"} ! uncondensed odontogenic mesenchyme +relationship: immediately_deep_to UBERON:0005176 ! tooth enamel organ relationship: part_of UBERON:0008281 ! tooth bud property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/22/Gray1011.png xsd:anyURI property_value: UBPROP:0000001 "Cell condensation that is a well-defined population of densely organized mesenchymal cells that aggregates adjacent to an epithelium.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000025", ontology="VSAO", source="PSPUB:0000170"} @@ -223897,6 +328397,7 @@ xref: UMLS:C0024957 {source="ncithesaurus:Maxillary_Sinus"} xref: Wikipedia:Maxillary_sinus is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001825 ! paranasal sinus +relationship: in_lateral_side_of UBERON:0000033 ! head relationship: part_of UBERON:0002397 ! maxilla property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray1199.png xsd:anyURI property_value: RO:0002161 NCBITaxon:33554 @@ -223930,6 +328431,10 @@ xref: Wikipedia:Lactiferous_duct is_a: UBERON:0000058 ! duct is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: channel_for UBERON:0001913 ! milk +relationship: channels_into UBERON:0002030 ! nipple property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg xsd:anyURI [Term] @@ -224027,7 +328532,6 @@ xref: NCIT:C12811 xref: SCTID:280648000 xref: UMLS:C0042160 {source="ncithesaurus:Uvea"} xref: Wikipedia:Uvea -is_a: BFO:0000040 ! material entity is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 {source="FMA"} ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -224049,6 +328553,7 @@ namespace: uberon def: "the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [ISBN:0-683-40008-8, MP:0001322] def: "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." [ISBN:0-683-40008-8, MP:0001322] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224082,6 +328587,7 @@ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0011892 ! anterior uvea relationship: develops_from UBERON:0004128 {source="XAO"} ! optic vesicle relationship: part_of UBERON:0011892 ! anterior uvea +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000101", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000101", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000101", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} @@ -224114,8 +328620,9 @@ xref: XAO:0000283 xref: ZFA:0001283 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 {source="AAO", source="FMA"} ! anatomical space +relationship: contributes_to_morphology_of UBERON:0001769 ! iris relationship: part_of UBERON:0001769 ! iris -property_value: depicted:by Eye:iris.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/65/Eye_iris.jpg xsd:anyURI property_value: UBPROP:0000001 "The circular orifice in the centre of the iris, through which light enters into the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000116", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000116", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} @@ -224126,6 +328633,7 @@ namespace: uberon def: "the smooth stratified squamous epithelium that covers the outer surface of the cornea" [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] def: "The smooth stratified squamous epithelium that covers the outer surface of the cornea." [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224172,6 +328680,7 @@ relationship: contributes_to_morphology_of UBERON:0000964 ! cornea relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm relationship: part_of UBERON:0000964 ! cornea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002187", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"} property_value: UBPROP:0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei" xsd:string property_value: UBPROP:0000008 "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" xsd:string @@ -224260,6 +328769,7 @@ name: ciliary body namespace: uberon def: "the thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes" [http://en.wikipedia.org/wiki/Ciliary_body, ISBN:0-683-40008-8, MP:0005099] def: "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." [ISBN:0-683-40008-8, MP:0005099, Wikipedia:Ciliary_body] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224284,12 +328794,12 @@ xref: http://www.snomedbrowser.com/Codes/Details/263340007 xref: MA:0000264 xref: MESH:D002924 xref: NCIT:C12345 +xref: neuronames:1571 xref: SCTID:263340007 xref: UMLS:C0008779 {source="ncithesaurus:Ciliary_Body"} xref: VHOG:0000102 xref: Wikipedia:Ciliary_body xref: XAO:0000186 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0011892 ! anterior uvea @@ -224298,6 +328808,7 @@ relationship: has_part UBERON:0001605 ! ciliary muscle relationship: has_part UBERON:0010427 ! ciliary processes relationship: part_of UBERON:0011892 ! anterior uvea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)"} property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"} @@ -224307,6 +328818,7 @@ name: optic choroid namespace: uberon def: "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [Wikipedia:Choroid] def: "vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [http://en.wikipedia.org/wiki/Choroid] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224351,6 +328863,7 @@ relationship: part_of UBERON:0001768 {source="MA"} ! uvea relationship: part_of UBERON:0019207 ! chorioretinal region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: editor_note "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "choroidal" xsd:string property_value: UBPROP:0000012 "MP treats posterior uvea and optic choroid as distinct" xsd:string {external_ontology="MP"} @@ -224400,6 +328913,7 @@ name: ciliary epithelium namespace: uberon def: "A double layer covering the ciliary body that produces aqueous humor." [Wikipedia:Ciliary_body#Ciliary_epithelium] def: "A double layer covering the ciliary body that produces aqueous humor." [http://en.wikipedia.org/wiki/Ciliary_body#Ciliary_epithelium] +subset: human_reference_atlas synonym: "ciliary body epithelium" EXACT [FMA:58464] synonym: "epithelium of ciliary body" EXACT [FMA:58464] synonym: "ocular ciliary epithelium" EXACT [] @@ -224422,6 +328936,7 @@ intersection_of: part_of UBERON:0001775 ! ciliary body relationship: has_part GO:0048770 {source="MP"} ! pigment granule relationship: part_of UBERON:0001775 {source="MA"} ! ciliary body relationship: produces UBERON:0001796 {source="Wikipedia"} ! aqueous humor of eyeball +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001779 @@ -224452,6 +328967,7 @@ id: UBERON:0001780 name: spinal nerve namespace: uberon def: "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." [MESH:A08.800.800.720, MP:0001077] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "backbone nerve" EXACT [OBOL:automatic] @@ -224472,10 +328988,10 @@ xref: EHDAA2:0001898 xref: EMAPA:16989 xref: FMA:5858 xref: GAID:841 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1228 xref: MA:0000233 xref: MESH:D013127 xref: NCIT:C12792 +xref: neuronames:1228 xref: OpenCyc:Mx4rwK_iFJwpEbGdrcN5Y29ycA xref: SCTID:361099009 xref: UMLS:C0037941 {source="ncithesaurus:Spinal_Nerve"} @@ -224486,7 +329002,8 @@ is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0002240 ! spinal cord -property_value: depicted:by Spinal:nerve.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000824", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/spinal+nerve"} [Term] @@ -224520,6 +329037,7 @@ id: UBERON:0001782 name: pigmented layer of retina namespace: uberon def: "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]." [Wikipedia:Retinal_pigment_epithelium, ZFIN:curator] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224560,8 +329078,14 @@ xref: ZFA:0000144 is_a: UBERON:0000957 ! lamina is_a: UBERON:0001781 ! layer of retina is_a: UBERON:0015808 ! eye epithelium +intersection_of: UBERON:0001781 ! layer of retina +intersection_of: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium +relationship: adjacent_to UBERON:0001787 ! photoreceptor layer of retina +relationship: adjacent_to UBERON:0003902 ! retinal neural layer +relationship: has_part GO:0048770 ! pigment granule relationship: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000144", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The monolayer of pigmented epithelium covering the neural retina.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011096", ontology="AAO", source="ZFA:0000144"} property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000536", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -224596,6 +329120,7 @@ xref: VHOG:0000551 xref: Wikipedia:Optic_disc is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II relationship: part_of UBERON:0000966 ! retina property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ed/Gray879.png xsd:anyURI property_value: UBPROP:0000001 "The small blind spot on the surface of the retina. It is the point where the fibers of the retina leave the eye and become part of the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000551", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+disc"} @@ -224606,6 +329131,7 @@ id: UBERON:0001785 name: cranial nerve namespace: uberon def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." [Wikipedia:Cranial_nerve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224621,11 +329147,11 @@ xref: EMAPA:17264 xref: FMA:5865 xref: GAID:802 xref: HBA:9299 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1227 xref: MA:0000215 xref: MBA:967 xref: MESH:D003391 xref: NCIT:C12700 +xref: neuronames:1227 xref: OpenCyc:Mx4rvWvJVpwpEbGdrcN5Y29ycA xref: SCTID:244447006 xref: TAO:0000641 @@ -224647,6 +329173,7 @@ relationship: has_developmental_contribution_from UBERON:0003099 ! cranial neura property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg xsd:anyURI property_value: editor_note "classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000641", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000279", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6" xsd:string @@ -224712,6 +329239,7 @@ xref: Wikipedia:Layer_of_rods_and_cones xref: XAO:0003215 xref: ZFA:0000143 is_a: UBERON:0001781 ! layer of retina +relationship: adjacent_to UBERON:0001788 ! outer limiting layer of retina relationship: part_of UBERON:0003902 ! retinal neural layer property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png xsd:anyURI property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -224747,12 +329275,14 @@ xref: Wikipedia:External_limiting_membrane xref: XAO:0003224 xref: ZFA:0001331 is_a: UBERON:0007619 {source="MA"} ! limiting membrane of retina +relationship: adjacent_to UBERON:0001789 ! outer nuclear layer of retina [Term] id: UBERON:0001789 name: outer nuclear layer of retina namespace: uberon def: "The layer within the retina where the photoreceptor cell bodies reside." [ZFA:0001464] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "external nuclear layer" RELATED [BTO:0005600] @@ -224780,7 +329310,10 @@ xref: Wikipedia:Outer_nuclear_layer xref: XAO:0003219 xref: ZFA:0001464 is_a: UBERON:0001781 ! layer of retina +relationship: adjacent_to UBERON:0001790 ! outer plexiform layer of retina +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer relationship: part_of UBERON:0003902 ! retinal neural layer +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001170", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} [Term] @@ -224813,6 +329346,8 @@ xref: Wikipedia:Outer_plexiform_layer xref: XAO:0003218 xref: ZFA:0001330 is_a: UBERON:0001781 ! layer of retina +relationship: adjacent_to UBERON:0001791 ! inner nuclear layer of retina +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer relationship: part_of UBERON:0003902 ! retinal neural layer property_value: UBPROP:0000001 "The layer within the retina where the bipolar cells synapse with the photoreceptor cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001330", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001171", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -224823,6 +329358,7 @@ name: inner nuclear layer of retina namespace: uberon def: "Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia)." [NLX:93816] comment: AO notes NLXANAT:1005031 appears to be retired +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "INL" NARROW [] @@ -224851,7 +329387,13 @@ xref: Wikipedia:Inner_nuclear_layer xref: XAO:0003221 xref: ZFA:0000119 is_a: UBERON:0001781 ! layer of retina +relationship: adjacent_to UBERON:0001795 ! inner plexiform layer of retina +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer +relationship: has_part CL:0000561 ! amacrine cell +relationship: has_part CL:0000745 ! retina horizontal cell +relationship: has_part CL:0000748 ! retinal bipolar neuron relationship: part_of UBERON:0003902 ! retinal neural layer +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The layer of the retina composed of the cell bodies of bipolar cells, horizontal cells, and some of the cell bodies of amacrine cells[BTO:0003176]." xsd:string {source="BTO:0003176"} property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001167", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -224860,6 +329402,7 @@ id: UBERON:0001792 name: ganglionic layer of retina namespace: uberon def: "Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer." [NLX:36500] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -224890,8 +329433,12 @@ xref: Wikipedia:Ganglion_cell_layer xref: XAO:0003223 xref: ZFA:0000024 is_a: UBERON:0001781 {source="FMA"} ! layer of retina +relationship: adjacent_to UBERON:0001793 ! nerve fiber layer of retina +relationship: composed_primarily_of CL:0000740 ! retinal ganglion cell +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer relationship: part_of UBERON:0003902 {source="FMA"} ! retinal neural layer property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." xsd:string {source="Wikipedia:Ganglion_cell_layer"} property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" xsd:string {external_ontology="NIF"} @@ -224927,6 +329474,10 @@ xref: Wikipedia:Nervous_system_fiber_layer xref: XAO:0003220 xref: ZFA:0001619 is_a: UBERON:0001781 ! layer of retina +relationship: adjacent_to UBERON:0001794 ! inner limiting layer of retina +relationship: composed_primarily_of GO:0030424 ! axon +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer +relationship: overlaps UBERON:0000941 ! cranial nerve II relationship: part_of UBERON:0003902 {source="FMA"} ! retinal neural layer property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001169", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -224957,6 +329508,10 @@ xref: Wikipedia:Inner_limiting_membrane xref: XAO:0003222 xref: ZFA:0001029 is_a: UBERON:0007619 {source="MA"} ! limiting membrane of retina +relationship: adjacent_to UBERON:0001797 ! vitreous humor +relationship: has_part CL:0000127 ! astrocyte +relationship: has_part GO:0043005 ! neuron projection +relationship: overlaps CL:0000636 ! Mueller cell property_value: editor_note "TODO - check frog/fish" xsd:string property_value: UBPROP:0000001 "Membrane on the apical surface of the retina. The retinal vasculature becomes adhered to the apical surface of the ILM by 30dpf[ZFIN:ZDB-PUB-071023-7, ZFIN:ZDB-PUB-120529-3]." xsd:string {source="ZFIN:ZDB-PUB-071023-7, ZFIN:ZDB-PUB-120529-3"} @@ -224993,6 +329548,15 @@ xref: Wikipedia:Inner_plexiform_layer xref: XAO:0003225 xref: ZFA:0001329 is_a: UBERON:0001781 ! layer of retina +intersection_of: UBERON:0001781 ! layer of retina +intersection_of: adjacent_to UBERON:0001791 ! inner nuclear layer of retina +intersection_of: adjacent_to UBERON:0001792 ! ganglionic layer of retina +relationship: adjacent_to UBERON:0001791 ! inner nuclear layer of retina +relationship: adjacent_to UBERON:0001792 ! ganglionic layer of retina +relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer +relationship: has_part GO:0030425 ! dendrite +relationship: overlaps CL:0000740 ! retinal ganglion cell +relationship: overlaps CL:0000748 ! retinal bipolar neuron relationship: part_of UBERON:0003902 ! retinal neural layer property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png xsd:anyURI property_value: UBPROP:0000001 "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842]." xsd:string {source="GO:0010842"} @@ -225041,6 +329605,14 @@ property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that t property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0001797 +name: vitreous humor +is_a: UBERON:0006312 ! ocular refractive media +relationship: has_quality PATO:0000964 ! transparent +relationship: located_in UBERON:0005606 ! hyaloid cavity +relationship: part_of UBERON:0001798 ! vitreous body + [Term] id: UBERON:0001798 name: vitreous body @@ -225052,13 +329624,15 @@ xref: CALOHA:TS-0308 xref: FMA:58827 xref: GAID:919 xref: MA:0002462 -xref: MESH:A09.371.943 +xref: MESH:D014822 xref: NCIT:C33884 xref: SCTID:181170006 xref: UMLS:C0042905 {source="ncithesaurus:Vitreous_Body"} is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue +relationship: composed_primarily_of UBERON:0001797 ! vitreous humor +relationship: has_developmental_contribution_from UBERON:0002346 ! neurectoderm relationship: part_of UBERON:0001799 ! vitreous chamber of eyeball property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI property_value: editor_note "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" xsd:string @@ -225085,6 +329659,9 @@ xref: NCIT:C33885 xref: UMLS:C0229095 {source="ncithesaurus:Vitreous_Chamber"} xref: Wikipedia:Vitreous_chamber is_a: UBERON:0006311 ! chamber of eyeball +intersection_of: UBERON:0006311 ! chamber of eyeball +intersection_of: location_of UBERON:0001798 ! vitreous body +relationship: location_of UBERON:0001798 ! vitreous body relationship: part_of UBERON:0001802 ! posterior segment of eyeball [Term] @@ -225183,6 +329760,7 @@ id: UBERON:0001803 name: epithelium of lens namespace: uberon def: "A layer of epithelial cells that is part of the eye." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "epithelial tissue of eye lens" EXACT [OBOL:automatic] @@ -225212,6 +329790,7 @@ intersection_of: part_of UBERON:0000965 ! lens of camera-type eye relationship: contributes_to_morphology_of UBERON:0000965 ! lens of camera-type eye relationship: part_of UBERON:0000965 ! lens of camera-type eye property_value: IAO:0000232 "this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001804 @@ -225305,6 +329884,7 @@ xref: EHDAA2:0001969 xref: EMAPA:17157 xref: FMA:5890 xref: MA:0000226 +xref: MESH:D005728 xref: NCIT:C12467 xref: SCTID:362485003 xref: UMLS:C0017071 {source="ncithesaurus:Sympathetic_Ganglion"} @@ -225364,6 +329944,7 @@ xref: EHDAA2:0001400 xref: EMAPA:32813 xref: FMA:5894 xref: MA:0002469 +xref: MESH:D005726 xref: NCIT:C52557 xref: NLXANAT:100303 xref: SCTID:279284004 @@ -225398,7 +329979,8 @@ relationship: part_of UBERON:0002005 ! enteric nervous system id: UBERON:0001810 name: nerve plexus namespace: uberon -def: "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." [FMA:5901, Wikipedia:Nervous_system_plexus] +def: "Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]." [FMA:5901, https://github.com/obophenotype/cell-ontology/issues/1306, Wikipedia:Nervous_system_plexus] +subset: human_reference_atlas subset: uberon_slim synonym: "plexus" BROAD [] xref: AEO:0000138 @@ -225413,7 +329995,9 @@ xref: SCTID:122455009 xref: UMLS:C0501403 {source="ncithesaurus:Nerve_Plexus"} xref: Wikipedia:Nervous_system_plexus is_a: UBERON:0003714 ! neural tissue -property_value: UBPROP:0000012 "in FMA this is a subtype of junction rather than tissue" xsd:string {external_ontology="FMA"} +is_a: UBERON:0007651 ! anatomical junction +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000012 "Made to be a subtype of junction rather than tissue to be consistent with FMA" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0001811 @@ -225436,7 +330020,7 @@ xref: EV:0100340 xref: FMA:59011 xref: GAID:898 xref: MA:0000265 -xref: MESH:A09.371.192 +xref: MESH:D003228 xref: NCIT:C12341 xref: SCTID:181161008 xref: UMLS:C0009758 {source="ncithesaurus:Conjunctiva"} @@ -225444,6 +330028,9 @@ xref: Wikipedia:Conjunctiva xref: XAO:0000182 is_a: UBERON:0000060 {source="FMA"} ! anatomical wall is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: adjacent_to UBERON:0001711 ! eyelid +relationship: adjacent_to UBERON:0001773 ! sclera +relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm relationship: part_of UBERON:0005908 {source="cjm"} ! conjunctival sac relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region @@ -225487,6 +330074,9 @@ xref: SCTID:42280003 xref: UMLS:C0228603 {source="ncithesaurus:Spinal_Nerve_Plexus"} xref: VHOG:0000925 is_a: UBERON:0001810 ! nerve plexus +intersection_of: UBERON:0001810 ! nerve plexus +intersection_of: extends_fibers_into UBERON:0001780 ! spinal nerve +relationship: extends_fibers_into UBERON:0001780 ! spinal nerve property_value: UBPROP:0000003 "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000926", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.436", source="http://bgee.unil.ch/"} [Term] @@ -225494,6 +330084,7 @@ id: UBERON:0001814 name: brachial nerve plexus namespace: uberon def: "An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]." [UBERON:cjm, Wikipedia:Brachial_plexus] +subset: human_reference_atlas subset: uberon_slim synonym: "brachial plexus" EXACT [MA:0001180] synonym: "plexus brachialis" RELATED [Wikipedia:Brachial_plexus] @@ -225511,10 +330102,15 @@ xref: SCTID:181002002 xref: UMLS:C0006090 {source="ncithesaurus:Brachial_Plexus"} xref: VHOG:0000372 xref: Wikipedia:Brachial_plexus +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001813 ! spinal nerve plexus +intersection_of: UBERON:0001813 ! spinal nerve plexus +intersection_of: innervates UBERON:0002102 ! forelimb +relationship: innervates UBERON:0002102 ! forelimb property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c9/Brachial_plexus_color.svg xsd:anyURI property_value: editor_note "check superclass - nerve vs collection of fibers vs junction; note that FMA also has 'brachial autonomic nerve plexus'" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A nerve plexus originating from the anterior branches of the last four cervical and the first thoracic spinal nerves, giving off many of the principal nerves of the shoulder, chest, and arms. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000372", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/brachial+plexus"} property_value: UBPROP:0000003 "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000372", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.436", source="http://bgee.unil.ch/"} @@ -225541,7 +330137,11 @@ xref: SCTID:181049003 xref: UMLS:C0024093 {source="ncithesaurus:Lumbosacral_Plexus"} xref: VHOG:0000926 xref: Wikipedia:Lumbosacral_plexus +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001813 ! spinal nerve plexus +intersection_of: UBERON:0001813 ! spinal nerve plexus +intersection_of: innervates UBERON:0002103 ! hindlimb +relationship: innervates UBERON:0002103 ! hindlimb property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png xsd:anyURI [Term] @@ -225560,6 +330160,8 @@ xref: FMA:5910 xref: MA:0000221 xref: SCTID:362482000 is_a: UBERON:0001810 ! nerve plexus +intersection_of: UBERON:0001810 ! nerve plexus +intersection_of: part_of UBERON:0002410 ! autonomic nervous system relationship: part_of UBERON:0002410 ! autonomic nervous system [Term] @@ -225641,6 +330243,9 @@ xref: Wikipedia:Meibomian_gland is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0013231 ! sebaceous gland of eyelid is_a: UBERON:0015251 {source="ISBN:0123813611", source="MA"} ! modified sebaceous gland +intersection_of: UBERON:0001821 ! sebaceous gland +intersection_of: part_of UBERON:0004772 ! eyelid tarsus +relationship: contributes_to_morphology_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0004772 ! eyelid tarsus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray1205.png xsd:anyURI property_value: UBPROP:0000011 "in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening[PMID:20664693]" xsd:string @@ -225689,7 +330294,12 @@ xref: VHOG:0001467 xref: Wikipedia:Sweat_gland is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0002530 ! gland +intersection_of: produces UBERON:0001089 ! sweat relationship: develops_from UBERON:0005089 {evidence="definitional"} ! sweat gland placode +relationship: has_quality PATO:0002299 ! tubular +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia +relationship: produces UBERON:0001089 ! sweat property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI property_value: editor_note "TODO - check if all sweat glands are epidermal - see EMAPA:29743" xsd:string property_value: UBPROP:0000001 "A gland that secretes sweat, found in the dermis or subcutaneous tissue, opening by a duct on the body surface. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001467", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sweat+gland"} @@ -225701,6 +330311,7 @@ id: UBERON:0001821 name: sebaceous gland namespace: uberon def: "A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]." [MP:0000647, Wikipedia:Sebaceous_gland] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -225724,9 +330335,12 @@ is_a: UBERON:0007771 ! epidermis gland is_a: UBERON:0012344 {source="Wikipedia"} ! holocrine gland is_a: UBERON:0019319 ! exocrine gland of integumental system relationship: develops_from UBERON:0005088 {evidence="definitional"} ! sebaceous gland placode +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0011932 ! pilosebaceous unit +relationship: produces UBERON:0001866 ! sebum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/49/HairFollicle.png xsd:anyURI property_value: IAO:0000232 "sebaceous glands are also found in glabrous areas of eyelids, nose, penis, labia minora and nipples, and do not always secrete into hair follices. This causes some confusion in classification. In addition some structures, such as preputial glands are sometimes called 'modified' sebaceous glands, implying a non-subclass relationship. we follow MP and MA in keeping this class generic and creating a distinct subclass for sebaceuous glands of the skin. The FMA class may be better placed under this subclass." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the numerous holocrine glands in the dermis that empty into a hair follicle and produce and secrete sebum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001468", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sebaceous+gland"} property_value: UBPROP:0000003 "Sebaceous glands are also limited to mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001468", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.102", source="http://bgee.unil.ch/"} @@ -225742,6 +330356,7 @@ xref: CALOHA:TS-0655 xref: EMAPA:37681 {source="MA:th"} xref: FMA:59502 xref: MA:0001883 +xref: MESH:D055171 xref: NCIT:C49593 xref: SCTID:278941001 xref: UMLS:C0225415 {source="ncithesaurus:Nasal_Cartilage"} @@ -225750,6 +330365,9 @@ is_a: UBERON:0002418 {source="MA"} ! cartilage tissue is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007844 ! cartilage element +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0000004 ! nose +relationship: location_of UBERON:0000402 ! nasal vestibule relationship: part_of UBERON:0000004 ! nose property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png xsd:anyURI @@ -225804,9 +330422,11 @@ xref: SCTID:181203001 xref: UMLS:C0030471 {source="ncithesaurus:Paranasal_Sinus"} xref: Wikipedia:Paranasal_sinuses is_a: UBERON:0002553 ! anatomical cavity +relationship: continuous_with UBERON:0001707 ! nasal cavity +relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003129 ! skull -property_value: depicted:by Nnh:front.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg xsd:anyURI property_value: UBPROP:0000011 "Arise as epithelial lined diverticula of the lining of the nasal cavity. The extent of sinus development varies with species, most of the development occurs postnatally" xsd:string property_value: UBPROP:0000202 FMA:76587 @@ -225831,6 +330451,9 @@ xref: Wikipedia:Mucous_membrane_of_nose is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0015788 ! olfactory apparatus chamber +relationship: bounding_layer_of UBERON:0015788 ! olfactory apparatus chamber relationship: part_of UBERON:0015788 ! olfactory apparatus chamber property_value: editor_note "TODO - check lining vs part of. split olfactory and nasal mucosa?" xsd:string @@ -225886,7 +330509,7 @@ xref: FMA:59762 xref: GAID:1257 xref: galen:Gingiva xref: MA:0000342 -xref: MESH:A14.254.646.480 +xref: MESH:D005881 xref: NCIT:C32677 xref: OpenCyc:Mx4rvViWnZwpEbGdrcN5Y29ycA xref: SCTID:181224006 @@ -225894,8 +330517,11 @@ xref: UMLS:C0017562 {source="ncithesaurus:Gingiva"} xref: VHOG:0001269 xref: Wikipedia:Gingiva is_a: UBERON:0003729 ! mouth mucosa +relationship: adjacent_to UBERON:0004103 ! alveolar ridge +relationship: adjacent_to UBERON:0008266 ! periodontal ligament +relationship: continuous_with UBERON:0003729 ! mouth mucosa relationship: part_of UBERON:0011595 ! jaw region -property_value: depicted:by Tooth:Section.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg xsd:anyURI property_value: editor_note "FMA has a 3-level breakdown of jaws into: region, jaw (skeleton+gums), skeleton." xsd:string property_value: UBPROP:0000007 "gingival" xsd:string @@ -225914,6 +330540,7 @@ xref: SCTID:303049006 xref: UMLS:C0930553 {source="ncithesaurus:Major_Salivary_Gland"} is_a: UBERON:0001044 ! saliva-secreting gland is_a: UBERON:0015212 ! lateral structure +relationship: in_lateral_side_of UBERON:0000165 ! mouth property_value: UBPROP:0000008 "There are 3 pairs of major salivary glands in human and mouse" xsd:string {source="ISBN:0123813611"} [Term] @@ -225970,6 +330597,7 @@ is_a: UBERON:0001829 ! major salivary gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0012102 ! buccal salivary gland relationship: develops_from UBERON:0008801 ! parotid gland primordium +relationship: in_lateral_side_of UBERON:0001710 ! lower jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg xsd:anyURI property_value: UBPROP:0000001 "A mammalian salivary gland located caudal to the ear. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-22, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000308", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000308", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.525", source="http://bgee.unil.ch/"} @@ -226002,6 +330630,7 @@ xref: VHOG:0000363 xref: Wikipedia:Sublingual_gland is_a: UBERON:0001829 {source="FMA"} ! major salivary gland relationship: develops_from UBERON:0006297 ! sublingual gland primordium +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png xsd:anyURI property_value: UBPROP:0000001 "One of a pair of small salivary glands situated under the mucous membrane of the floor of the mouth, beneath the tongue. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000363", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sublingual+gland"} property_value: UBPROP:0000003 "Most mammals have well-developed parotid, mandibular, and sublingual glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000363", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.553", source="http://bgee.unil.ch/"} @@ -226039,6 +330668,7 @@ xref: VHOG:0000677 xref: Wikipedia:Lip xref: ZFA:0007006 is_a: UBERON:0003102 {source="ZFA"} ! surface structure +disjoint_from: UBERON:0004084 ! genital labium relationship: contributes_to_morphology_of UBERON:0000165 ! mouth relationship: part_of UBERON:0000165 {source="BTO", source="FMA-implicit", source="VHOG", source="ZFA"} ! mouth relationship: surrounds UBERON:0000166 {source="cjm"} ! oral opening @@ -226071,6 +330701,8 @@ xref: Wikipedia:Upper_lip xref: ZFA:0005226 is_a: UBERON:0001833 ! lip is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001833 ! lip +intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: immediate_transformation_of UBERON:0011592 ! future upper lip relationship: part_of UBERON:0001709 ! upper jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg xsd:anyURI @@ -226113,6 +330745,12 @@ relationship: part_of UBERON:0001710 ! lower jaw region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg xsd:anyURI property_value: UBPROP:0000001 "Lip that covers the lower portion of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002060", ontology="TAO", source="TAO:wd"} +[Term] +id: UBERON:0001836 +name: saliva +is_a: UBERON:0000456 ! secretion of exocrine gland +relationship: capable_of_part_of GO:0007586 ! digestion + [Term] id: UBERON:0001837 name: duct of salivary gland @@ -226135,6 +330773,12 @@ xref: Wikipedia:Salivary_duct is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000025 ! tube is_a: UBERON:0003928 ! digestive system duct +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland +relationship: channel_for UBERON:0001836 ! saliva +relationship: channels_from UBERON:0001044 ! saliva-secreting gland +relationship: channels_into UBERON:0000165 ! mouth +relationship: contributes_to_morphology_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0001044 ! saliva-secreting gland [Term] @@ -226151,6 +330795,10 @@ xref: MA:0002699 xref: SCTID:281000009 xref: Wikipedia:Sublingual_duct is_a: UBERON:0001837 ! duct of salivary gland +intersection_of: UBERON:0001837 ! duct of salivary gland +intersection_of: part_of UBERON:0001832 ! sublingual gland +relationship: channels_from UBERON:0001832 ! sublingual gland +relationship: contributes_to_morphology_of UBERON:0001832 ! sublingual gland relationship: part_of UBERON:0001832 ! sublingual gland [Term] @@ -226356,6 +331004,7 @@ xref: ZFA:0000374 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034921 ! multi organ part structure +relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001839 {source="FMA", source="VHOG", source="XAO", source="ncit"} ! bony labyrinth property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg xsd:anyURI @@ -226380,7 +331029,7 @@ xref: EMAPA:36549 xref: FMA:60908 xref: GAID:1185 xref: MA:0002529 -xref: MESH:A12.207.571.678 +xref: MESH:D010498 xref: NCIT:C33297 xref: TAO:0005413 xref: UMLS:C0031059 {source="ncithesaurus:Perilymph"} @@ -226479,6 +331128,9 @@ xref: MA:0001227 xref: SCTID:279627003 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0034944 ! zone of organ +intersection_of: UBERON:0034944 ! zone of organ +intersection_of: part_of UBERON:0001757 ! pinna +intersection_of: part_of UBERON:0001867 ! cartilage of external ear relationship: part_of UBERON:0001757 ! pinna relationship: part_of UBERON:0001867 ! cartilage of external ear @@ -226509,6 +331161,7 @@ is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003051 ! ear vesicle +relationship: located_in UBERON:0004637 ! otic capsule relationship: part_of UBERON:0001846 {source="FMA", source="MA"} ! internal ear property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray924.png xsd:anyURI property_value: UBPROP:0000001 "A system of communicating epithelial sacs and ducts within the bony labyrinth, containing the endolymph. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000729", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/membranous+labyrinth"} @@ -226531,6 +331184,10 @@ xref: SCTID:280426002 is_a: UBERON:0000062 {source="FMA"} ! organ is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland +relationship: connects UBERON:0001707 ! nasal cavity +relationship: connects UBERON:0010284 ! lacrimal punctum +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of UBERON:0001750 {source="FMA"} ! lacrimal apparatus property_value: editor_note "TODO - resolve lacrimal canaliculus vs larcimal duct" xsd:string property_value: RO:0002161 NCBITaxon:8459 {source="PMID:7559104"} @@ -226552,6 +331209,7 @@ xref: FMA:61109 xref: galen:Cortex xref: Wikipedia:Cortex_(anatomy) is_a: UBERON:0000064 ! organ part +relationship: bounding_layer_of UBERON:0000062 ! organ property_value: UBPROP:0000007 "cortical" xsd:string property_value: UBPROP:0000012 "this class is used more generically than in FMA, and includes e.g. cortex of hair" xsd:string {external_ontology="FMA"} @@ -226571,7 +331229,7 @@ xref: EMAPA:36548 xref: FMA:61112 xref: GAID:1184 xref: MA:0002528 -xref: MESH:A12.207.571.324 +xref: MESH:D004710 xref: NCIT:C32513 xref: TAO:0005414 xref: UMLS:C0014166 {source="ncithesaurus:Endolymph"} @@ -226706,6 +331364,7 @@ synonym: "membranous semicircular canal" RELATED [MA:0000251] xref: EMAPA:32830 xref: FMA:61122 xref: MA:0000251 +xref: MESH:D054776 xref: NCIT:C33528 xref: SCTID:279833009 xref: UMLS:C1323109 {source="ncithesaurus:Semicircular_Duct"} @@ -226764,6 +331423,7 @@ xref: EMAPA:17286 xref: EMAPA:17815 xref: FMA:61255 xref: MA:0000245 +xref: MESH:D014722 xref: NCIT:C33871 xref: SCTID:181188003 xref: UMLS:C0042606 {source="ncithesaurus:Vestibular_Labyrinth"} @@ -226784,6 +331444,7 @@ subset: uberon_slim xref: EMAPA:35753 xref: FMA:61269 xref: MA:0001206 +xref: MESH:D054738 xref: SCTID:362578000 xref: Wikipedia:Scala_vestibuli is_a: UBERON:0011060 {source="MA"} ! perilymphatic channel @@ -226811,6 +331472,15 @@ is_a: UBERON:0013685 ! foramen of skull relationship: part_of UBERON:0001844 {source="FMA"} ! cochlea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png xsd:anyURI +[Term] +id: UBERON:0001866 +name: sebum +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0001821 ! sebaceous gland +relationship: has_part CHEBI:15440 ! squalene +relationship: produced_by UBERON:0001821 ! sebaceous gland + [Term] id: UBERON:0001867 name: cartilage of external ear @@ -226822,12 +331492,23 @@ xref: EMAPA:37706 {source="MA:th"} xref: FMA:61339 xref: GAID:103 xref: MA:0001886 -xref: MESH:A02.165.207 +xref: MESH:D004425 xref: NCIT:C49225 xref: UMLS:C0013445 {source="ncithesaurus:External_Ear_Cartilage"} is_a: UBERON:0007844 ! cartilage element +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0001691 ! external ear +relationship: composed_primarily_of UBERON:0001996 ! elastic cartilage tissue relationship: part_of UBERON:0001691 ! external ear +[Term] +id: UBERON:0001868 +name: skin of chest +is_a: UBERON:0001418 ! skin of thorax +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001443 ! chest +relationship: part_of UBERON:0001443 ! chest + [Term] id: UBERON:0001869 name: cerebral hemisphere @@ -226853,10 +331534,10 @@ xref: EFO:0002521 xref: EMAPA:16653 xref: FMA:61817 xref: galen:CerebralHemisphere -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241 {source="BIRNLEX:1042"} xref: MA:0000133 xref: MBA:403 xref: NCIT:C12351 +xref: neuronames:241 {source="BIRNLEX:1042"} xref: OpenCyc:Mx4rvigx5ZwpEbGdrcN5Y29ycA xref: SCTID:278251007 xref: UMLS:C0228174 {source="ncithesaurus:Cerebral_Hemisphere"} @@ -226897,6 +331578,8 @@ xref: MA:0000905 xref: NLXANAT:20090601 xref: Wikipedia:Frontal_lobe is_a: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: part_of UBERON:0016525 ! frontal lobe relationship: part_of UBERON:0016525 ! frontal lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray729.png xsd:anyURI property_value: UBPROP:0000001 "Anterior portion of the frontal cortex, lying anterior to the central sulcus. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally." xsd:string {source="NLXANAT:20090601"} @@ -226908,6 +331591,7 @@ namespace: uberon def: "Lower lateral part of the cerebral hemisphere. (MSH)." [BIRNLEX:1160] comment: Boundary notes: It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. [Wikipedia:Temporal_lobe] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lobus temporalis" EXACT LATIN [Wikipedia:Temporal_lobe] @@ -226924,10 +331608,10 @@ xref: EV:0100169 xref: FMA:61825 xref: GAID:635 xref: HBA:4132 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=125 {source="BIRNLEX:1160"} xref: MAT:0000508 -xref: MESH:A08.186.211.730.885.213.863 +xref: MESH:D013702 xref: NCIT:C12353 +xref: neuronames:125 {source="BIRNLEX:1160"} xref: OpenCyc:Mx4rwQLi-ZwpEbGdrcN5Y29ycA xref: SCTID:180921000 xref: UMLS:C0039485 {source="ncithesaurus:Temporal_Lobe"} @@ -226935,7 +331619,9 @@ xref: UMLS:C0039485 {source="BIRNLEX:1160"} xref: UMLS:C1268978 {source="BIRNLEX:1160"} xref: Wikipedia:Temporal_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere +relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/91/Gray730.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001872 @@ -226943,6 +331629,7 @@ name: parietal lobe namespace: uberon def: "Upper central part of the cerebral hemisphere. (MSH)." [BIRNLEX:1148] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lobus parietalis" RELATED LATIN [Wikipedia:Parietal_lobe] @@ -226958,17 +331645,20 @@ xref: EV:0100168 xref: FMA:61826 xref: GAID:680 xref: HBA:4084 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=95 {source="BIRNLEX:1148"} xref: MAT:0000506 -xref: MESH:A08.186.211.730.885.213.670 +xref: MESH:D010296 xref: NCIT:C12354 +xref: neuronames:95 {source="BIRNLEX:1148"} xref: OpenCyc:Mx4rvg-typwpEbGdrcN5Y29ycA xref: SCTID:180922007 xref: UMLS:C0030560 {source="BIRNLEX:1148"} xref: UMLS:C0030560 {source="ncithesaurus:Parietal_Lobe_of_the_Brain"} xref: Wikipedia:Parietal_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere +relationship: adjacent_to UBERON:0001871 ! temporal lobe +relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray726_parietal_lobe.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001873 @@ -226999,11 +331689,11 @@ xref: EV:0100185 xref: FMA:61833 xref: GAID:670 xref: HBA:4278 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=226 {source="BIRNLEX:1373"} xref: MA:0000894 xref: MAT:0000513 -xref: MESH:A08.186.211.730.885.105.487.550.184 +xref: MESH:D002421 xref: NCIT:C12451 +xref: neuronames:226 {source="BIRNLEX:1373"} xref: OpenCyc:Mx4rvvyAjJwpEbGdrcN5Y29ycA xref: PBA:10082 xref: SCTID:279297002 @@ -227020,6 +331710,7 @@ id: UBERON:0001874 name: putamen namespace: uberon def: "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion." [BIRNLEX:809] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus putamen" EXACT [] @@ -227035,10 +331726,10 @@ xref: EV:0100187 xref: FMA:61834 xref: GAID:671 xref: HBA:4287 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=230 {source="BIRNLEX:809"} xref: MA:0000895 -xref: MESH:A08.186.211.730.885.105.487.550.784 +xref: MESH:D011699 xref: NCIT:C12452 +xref: neuronames:230 {source="BIRNLEX:809"} xref: PBA:10086 xref: SCTID:281512002 xref: UMLS:C0034169 {source="ncithesaurus:Putamen"} @@ -227049,6 +331740,7 @@ relationship: part_of UBERON:0001869 {source="FMA"} ! cerebral hemisphere relationship: part_of UBERON:0005383 ! caudate-putamen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg xsd:anyURI property_value: editor_note "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]." xsd:string {source="Wikipedia:Putamen"} property_value: UBPROP:0000003 "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001456", ontology="VHOG", source="DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)", source="http://bgee.unil.ch/"} @@ -227078,11 +331770,11 @@ xref: EV:0100188 xref: FMA:61835 xref: GAID:668 xref: HBA:4293 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=231 {source="BIRNLEX:1234"} xref: MA:0000890 xref: MAT:0000510 -xref: MESH:A08.186.211.730.885.105.487.397 +xref: MESH:D005917 xref: NCIT:C12449 +xref: neuronames:231 {source="BIRNLEX:1234"} xref: PBA:10097 xref: SCTID:362361005 xref: UMLS:C0017651 {source="ncithesaurus:Globus_Pallidus"} @@ -227091,7 +331783,7 @@ xref: Wikipedia:Globus_pallidus is_a: UBERON:0009663 ! telencephalic nucleus relationship: part_of UBERON:0001869 ! cerebral hemisphere relationship: part_of UBERON:0006514 {source="MA"} ! pallidum -property_value: depicted:by Brain:structure.gif xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif xsd:anyURI property_value: UBPROP:0000001 "Nucleus of brain which is located medially to the putamen and laterally to the internal capsule[FMA][FMA:61835]." xsd:string {source="FMA:61835"} property_value: UBPROP:0000007 "pallidal" xsd:string @@ -227133,12 +331825,12 @@ xref: EV:0100190 xref: FMA:61841 xref: GAID:616 xref: HBA:4327 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=237 {source="BIRNLEX:1241"} xref: MA:0000887 xref: MAT:0000289 -xref: MESH:A08.186.211.577.090 +xref: MESH:D000679 xref: MIAA:0000289 xref: NCIT:C12440 +xref: neuronames:237 {source="BIRNLEX:1241"} xref: OpenCyc:Mx4rwJC_2ZwpEbGdrcN5Y29ycA xref: PBA:4002 xref: SCTID:279404004 @@ -227179,10 +331871,10 @@ xref: EMAPA:35452 xref: FMA:61888 xref: GAID:632 xref: HBA:265504792 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=276 {source="BIRNLEX:1113"} xref: MA:0000977 xref: MBA:481 -xref: MESH:A08.186.211.577.699.400 +xref: MESH:D020670 +xref: neuronames:276 {source="BIRNLEX:1113"} xref: PBA:10095 xref: UMLS:C0262264 {source="BIRNLEX:1113"} xref: Wikipedia:Islands_of_Calleja @@ -227216,12 +331908,12 @@ xref: EMAPA:32789 xref: FMA:61889 xref: GAID:672 xref: HBA:4290 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=277 {source="BIRNLEX:727"} xref: MA:0000892 xref: MAT:0000512 xref: MBA:56 -xref: MESH:A08.186.211.730.885.105.683 +xref: MESH:D009714 xref: NCIT:C52733 +xref: neuronames:277 {source="BIRNLEX:727"} xref: PBA:10092 xref: SCTID:427667007 xref: UMLS:C0028633 {source="ncithesaurus:Accumbens_Nucleus"} @@ -227257,6 +331949,7 @@ xref: EV:0100177 xref: HBA:10145 xref: MA:0000976 xref: MBA:754 +xref: MESH:D066208 xref: NLXANAT:1005037 xref: PBA:10096 xref: VHOG:0001625 @@ -227274,6 +331967,7 @@ id: UBERON:0001884 name: phrenic nerve namespace: uberon def: "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." [VHOG:0000728] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "diaphragmatic nerve" RELATED [BTO:0001063] @@ -227301,6 +331995,7 @@ intersection_of: supplies UBERON:0001103 ! diaphragm relationship: branching_part_of UBERON:0000962 ! nerve of cervical vertebra relationship: supplies UBERON:0001103 ! diaphragm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000728", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/phrenic+nerve"} [Term] @@ -227333,11 +332028,11 @@ xref: EMAPA:19037 xref: FMA:61922 xref: GAID:624 xref: HBA:12891 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=179 xref: MA:0000190 xref: MBA:726 -xref: MESH:A08.186.211.577.405.200 +xref: MESH:D018891 xref: NCIT:C32452 +xref: neuronames:179 xref: SCTID:279211002 xref: UMLS:C0152314 {source="ncithesaurus:Dentate_Gyrus"} xref: Wikipedia:Dentate_gyrus @@ -227374,11 +332069,11 @@ xref: EFO:0001915 xref: EMAPA:32741 xref: FMA:61934 xref: GAID:607 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1377 xref: MA:0000823 xref: MBA:108 xref: MESH:D002831 xref: NCIT:C12694 +xref: neuronames:1377 xref: SCTID:264450003 xref: TAO:0001443 xref: UMLS:C0008524 {source="ncithesaurus:Choroid_Plexus"} @@ -227389,6 +332084,7 @@ is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005629 ! vascular plexus is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system +relationship: contributes_to_morphology_of UBERON:0003947 ! brain ventricle/choroid plexus relationship: part_of UBERON:0004086 ! brain ventricle relationship: part_of UBERON:0005283 ! tela choroidea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray708.svg xsd:anyURI @@ -227437,6 +332133,7 @@ name: forebrain namespace: uberon def: "The most anterior region of the brain including both the telencephalon and diencephalon." [Wikipedia:Forebrain, ZFIN:ZDB-PUB-961014-576] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -227455,12 +332152,12 @@ xref: EHDAA2:0000556 xref: EHDAA:3470 xref: EMAPA:16895 xref: FMA:61992 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 {source="BIRNLEX:1509"} xref: MA:0000170 xref: MAT:0000105 xref: MESH:D016548 xref: MIAA:0000105 xref: NCIT:C40185 +xref: neuronames:27 {source="BIRNLEX:1509"} xref: SCTID:362291003 xref: TAO:0000109 xref: UMLS:C0085140 {source="ncithesaurus:Fore-Brain"} @@ -227470,10 +332167,12 @@ xref: Wikipedia:Forebrain xref: XAO:0000011 xref: ZFA:0000109 is_a: UBERON:0002616 ! regional part of brain +disjoint_from: UBERON:0002298 ! brainstem relationship: contributes_to_morphology_of UBERON:0000955 ! brain relationship: develops_from UBERON:0003080 ! anterior neural tube relationship: immediate_transformation_of UBERON:0006240 {evidence="definitional"} ! future forebrain property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010147", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO"} @@ -227486,6 +332185,7 @@ name: midbrain namespace: uberon def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [GO:0030901] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -227518,6 +332218,7 @@ xref: MBA:313 xref: MESH:D008636 xref: MIAA:0000106 xref: NCIT:C12510 +xref: neuronames:462 {source="BIRNLEX:1667"} xref: OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA xref: RETIRED_EHDAA2:0001104 xref: SCTID:279099009 @@ -227538,6 +332239,7 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f9/H property_value: editor_note "developmental relationships need revised" xsd:string property_value: RO:0002171 UBERON:0001894 {exceptions="ZFA", exceptions_url="https://github.com/obophenotype/uberon/issues/378", source="ABA", status="pending"} property_value: RO:0002171 UBERON:0002028 {exceptions="ZFA", source="ABA", status="pending"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Middle part of the brain composed of the optic tectum and penducular region.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010149", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000128", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000069", ontology="VHOG", source="DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", source="http://bgee.unil.ch/"} @@ -227595,7 +332297,7 @@ subset: pheno_slim subset: uberon_slim subset: vertebrate_core synonym: "cerebrum" EXACT [BTO:0000239, EMAPA:16910, FMA:62000, https://github.com/obophenotype/uberon/issues/1208, Wikipedia:Talk\:Cerebrum/Archive_1] -synonym: "endbrain" EXACT [http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31, Swanson:2004] +synonym: "endbrain" EXACT [neuronames:31, Swanson:2004] synonym: "supratentorial region" BROAD [Wikipedia:Tentorium_cerebelli] xref: AAO:0010479 xref: BAMS:CB @@ -227614,12 +332316,12 @@ xref: EV:0100165 xref: FMA:62000 xref: GAID:621 xref: HBA:4007 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 {source="BIRNLEX:1115"} xref: MA:0000183 xref: MAT:0000421 xref: MBA:567 xref: MESH:D013687 xref: MIAA:0000421 +xref: neuronames:31 {source="BIRNLEX:1115"} xref: PBA:128011350 xref: SCTID:263353005 xref: TAO:0000079 @@ -227687,13 +332389,13 @@ xref: EV:0100194 xref: FMA:62001 xref: GAID:618 xref: HBA:4391 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288 {source="BIRNLEX:1503"} xref: MA:0000171 xref: MAT:0000420 xref: MBA:1129 -xref: MESH:A08.186.211.730.385 +xref: MESH:D004027 xref: MIAA:0000420 xref: NCIT:C12456 +xref: neuronames:288 {source="BIRNLEX:1503"} xref: OpenCyc:Mx4rwC-V0JwpEbGdrcN5Y29ycA xref: PBA:128013010 xref: SCTID:279328001 @@ -227741,10 +332443,10 @@ xref: EMAPA:17071 xref: FMA:62003 xref: GAID:594 xref: HBA:4833 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543 {source="BIRNLEX:965"} xref: MA:0000197 xref: MESH:D020540 xref: NCIT:C32741 +xref: neuronames:543 {source="BIRNLEX:965"} xref: UMLS:C0376353 {source="BIRNLEX:965"} xref: UMLS:C1516904 {source="ncithesaurus:Epencephalon"} xref: VHOG:0000741 @@ -227765,6 +332467,7 @@ namespace: uberon def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, Wikipedia:Bone_marrow_of_ovary_oblongata] def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, http://en.wikipedia.org/wiki/Bone_marrow_of_ovary_oblongata] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -227802,6 +332505,7 @@ xref: MBA:354 xref: MESH:D008526 xref: MIAA:0000111 xref: NCIT:C12442 +xref: neuronames:698 {source="BIRNLEX:957"} xref: OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA xref: OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA xref: SCTID:279104005 @@ -227813,7 +332517,6 @@ xref: VHOG:0000181 xref: Wikipedia:Bone_marrow_of_ovary_oblongata xref: XAO:0003100 xref: ZFA:0000545 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -227823,6 +332526,7 @@ relationship: capable_of GO:0044058 ! regulation of digestive system process relationship: part_of UBERON:0002298 ! brainstem relationship: part_of UBERON:0005290 ! myelencephalon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010486", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -227858,13 +332562,12 @@ xref: EV:0100195 xref: GAID:656 xref: galen:Thalamus xref: HBA:4392 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=300 {source="BIRNLEX:954"} xref: MA:0000179 xref: MAT:0000109 xref: MBA:549 -xref: MESH:A08.186.211.730.385.826 xref: MIAA:0000109 xref: NCIT:C12459 +xref: neuronames:300 {source="BIRNLEX:954"} xref: OpenCyc:Mx4rwMPQ65wpEbGdrcN5Y29ycA xref: PBA:128013014 xref: SCTID:244433007 @@ -227875,6 +332578,8 @@ xref: VHOG:0000657 xref: Wikipedia:Thalamus xref: ZFA:0001215 is_a: UBERON:0002616 ! regional part of brain +relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon +relationship: in_lateral_side_of UBERON:0010225 ! thalamic complex relationship: part_of UBERON:0010225 ! thalamic complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ce/Brain_chrischan_thalamus.jpg xsd:anyURI property_value: RO:0002171 UBERON:0001898 {source="ABA"} @@ -227889,6 +332594,7 @@ name: hypothalamus namespace: uberon def: "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]." [Wikipedia:Hypothalamus, ZFIN:curator] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -227913,13 +332619,13 @@ xref: FMA:62008 xref: GAID:460 xref: galen:Hypothalamus xref: HBA:4540 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 {source="BIRNLEX:734"} xref: MA:0000173 xref: MAT:0000112 xref: MBA:1097 -xref: MESH:A08.186.211.577.482 +xref: MESH:D007031 xref: MIAA:0000112 xref: NCIT:C12458 +xref: neuronames:292 {source="BIRNLEX:734"} xref: OpenCyc:Mx4rwEgr9JwpEbGdrcN5Y29ycA xref: SCTID:264483005 xref: TAO:0000032 @@ -227930,6 +332636,7 @@ xref: Wikipedia:Hypothalamus xref: XAO:0004070 xref: ZFA:0000032 is_a: UBERON:0002616 ! regional part of brain +relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0000349 ! limbic system relationship: part_of UBERON:0010225 {missing_from="FMA", source="EHDAA2", source="Wikipedia"} ! thalamic complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/LocationOfHypothalamus.jpg xsd:anyURI @@ -227937,6 +332644,7 @@ property_value: RO:0002171 UBERON:0001897 {source="ABA"} property_value: RO:0002174 NCBITaxon:7737 {notes="Lancelets possess a region similar to the hypothalamus (Murakami, 2005)"} property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:7742 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000032", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Part of the diencephalon ventral to the thalamus consisting of connecting fibers and is a center for control of the autonomous nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010484", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "For instance, the vertebrate ventral diencephalon generates the hypothalamus which functions as a major endocrine center in cooperation with the hypophysis, the anterior part of the pituitary gland, located just ventral to the hypothalamus. In the amphioxus brain, the presence of a hypothalamus-like structure has been reported associated with the ventrally located Hatschek's pit, the hypothetical hypophysial homologue. It is thus conceivable that a hypothalamus-like structure originally involved in endocrine functions may have already been present before the establishment of vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000179", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", source="http://bgee.unil.ch/"} @@ -227949,6 +332657,7 @@ name: epithalamus namespace: uberon def: "Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346." [BIRNLEX:1710] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -227972,13 +332681,13 @@ xref: EV:0100220 xref: FMA:62009 xref: GAID:455 xref: HBA:4520 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 {source="BIRNLEX:1710"} xref: MA:0000172 xref: MAT:0000422 xref: MBA:958 -xref: MESH:A08.186.211.577.200 +xref: MESH:D019261 xref: MIAA:0000422 xref: NCIT:C12457 +xref: neuronames:292 {source="BIRNLEX:1710"} xref: OpenCyc:Mx4rvneLQpwpEbGdrcN5Y29ycA xref: PBA:128013147 xref: SCTID:281487003 @@ -227989,12 +332698,14 @@ xref: VHOG:0000178 xref: Wikipedia:Epithalamus xref: ZFA:0000509 is_a: UBERON:0002616 ! regional part of brain +relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cb/Epithalamus.png xsd:anyURI property_value: RO:0002171 UBERON:0001903 {source="ABA"} property_value: RO:0002171 UBERON:0002733 {source="ABA"} property_value: RO:0002171 UBERON:0002736 {source="ABA"} property_value: RO:0002175 NCBITaxon:7742 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Dorsal segment of the diencephalon containing the habenular ganglia, a choroid plexus, and the pineal organ.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010482", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The roof of the diencephalon lying above the thalamus. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-11, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000178", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The epithalamus has been historically conceived as a distinct neuroanatomical moiety within the diencephalon of all vertebrates. (...) The evolutionary origins of epithalamic structures are uncertain but asymmetry in this region is likely to have existed at the origin of the vertebrate, perhaps even the chordate, lineage.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000178", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910063.x Concha ML and Wilson SW, Asymmetry in the epithalamus of vertebrates. J Anat (2001)", source="http://bgee.unil.ch/"} @@ -228006,6 +332717,7 @@ name: ventral thalamus namespace: uberon def: "Anterior part of the diencephalon that lies between the dorsal thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis[GO, modified]." [GO:0021539] comment: Some sources treat the subthalamus as distinct from the thalamus, separated by the zona limitans intrathalamica. In MA, the ventral thalamus is part of the thalamus. Butler Hodos who identify a dorsal to ventral sequence consisting of epithalamus, dorsal thalamus, ventral thalamus and hypothalamus. We solve this by considering dorsal and ventral thalamus distinct, and the label thalamus as being ambiguous w.r.t thalamus proper (dorsal thalamus) or wider thalamus (dorsal plus ventral) +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -228032,10 +332744,10 @@ xref: EV:0100223 xref: FMA:62010 xref: GAID:653 xref: HBA:4504 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=434 {source="BIRNLEX:708"} xref: MA:0000181 -xref: MESH:A08.186.211.730.385.800 +xref: MESH:D020530 xref: NCIT:C52731 +xref: neuronames:434 {source="BIRNLEX:708"} xref: SCTID:279332007 xref: TAO:0000458 xref: UMLS:C0152349 {source="BIRNLEX:708"} @@ -228046,6 +332758,7 @@ is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus property_value: RO:0002175 NCBITaxon:117569 {source="Ariens, p. 1192"} property_value: RO:0002175 NCBITaxon:7742 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "subthalamic" xsd:string [Term] @@ -228054,6 +332767,7 @@ name: epithelium of trachea namespace: uberon alt_id: UBERON:0003227 def: "The epithelial lining of the trachea which contains numerous ciliated cells." [ISBN:0-397-51047-0, MGI:cwg, MP:0002285] +subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of trachea" EXACT [OBOL:automatic] synonym: "epithelial tissue of windpipe" EXACT [OBOL:automatic] @@ -228075,8 +332789,42 @@ xref: NCIT:C33797 xref: UMLS:C1179002 {source="ncithesaurus:Tracheal_Epithelium"} xref: VHOG:0001045 is_a: UBERON:0008397 ! tracheobronchial epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003126 ! trachea +relationship: contributes_to_morphology_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0003258 ! endoderm of foregut relationship: part_of UBERON:0003126 ! trachea +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001902 +name: epithelium of small intestine +namespace: uberon +def: "An epithelium that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +subset: vertebrate_core +synonym: "epithelial tissue of small bowel" EXACT [OBOL:automatic] +synonym: "epithelial tissue of small intestine" EXACT [OBOL:automatic] +synonym: "epithelium of small bowel" EXACT [OBOL:automatic] +synonym: "mid intestine epithelium" EXACT [ZFA:0005127] +synonym: "small bowel epithelial tissue" EXACT [OBOL:automatic] +synonym: "small bowel epithelium" EXACT [OBOL:automatic] +synonym: "small intestinal epithelium" EXACT [] +synonym: "small intestine epithelial tissue" EXACT [OBOL:automatic] +synonym: "small intestine epithelium" EXACT [] +xref: BTO:0001258 +xref: CALOHA:TS-2104 +xref: EMAPA:35778 +xref: FMA:62017 +xref: MA:0001553 +xref: SCTID:45480009 +xref: TAO:0005127 +xref: ZFA:0005127 +is_a: UBERON:0001277 ! intestinal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: has_part CL:0000164 {source="FMA"} ! enteroendocrine cell +relationship: part_of UBERON:0001204 ! mucosa of small intestine +property_value: UBPROP:0000001 "Intestinal epithelium which lines the lumen of the mid intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005127", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0001904 @@ -228105,9 +332853,9 @@ xref: EV:0100222 xref: FMA:62032 xref: GAID:619 xref: HBA:4522 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=294 {source="BIRNLEX:1611"} xref: MA:0000830 -xref: MESH:A08.186.211.577.200.360 +xref: MESH:D019262 +xref: neuronames:294 {source="BIRNLEX:1611"} xref: SCTID:362389008 xref: TAO:0000213 xref: UMLS:C0152362 {source="BIRNLEX:1611"} @@ -228126,6 +332874,7 @@ name: pineal body namespace: uberon def: "A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399)." [BIRNLEX:1184] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -228161,12 +332910,12 @@ xref: FMA:62033 xref: GAID:453 xref: galen:PinealGland xref: HBA:4532 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=297 {source="BIRNLEX:1184"} xref: MA:0000175 xref: MAT:0000448 xref: MBA:953 xref: MESH:D010870 xref: NCIT:C12398 +xref: neuronames:297 {source="BIRNLEX:1184"} xref: NLXANAT:1010009 xref: OpenCyc:Mx4rv2FMGpwpEbGdrcN5Y29ycA xref: SCTID:181126002 @@ -228179,11 +332928,15 @@ xref: XAO:0000160 xref: ZFA:0000019 is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010134 {source="MA"} ! secretory circumventricular organ +relationship: contributes_to_morphology_of UBERON:0001899 ! epithalamus +relationship: has_part CL:0000652 ! pinealocyte +relationship: has_part CL:0002220 ! interstitial cell of pineal gland relationship: part_of UBERON:0015238 {source="ZFA", source="various"} ! pineal complex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg xsd:anyURI property_value: RO:0002171 UBERON:0001941 {source="ABA"} property_value: RO:0002171 UBERON:0001942 {source="ABA"} property_value: RO:0002175 NCBITaxon:117569 {source="Hardisty, p. 310"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A circumscribed swelling, includes the pineal primordium that appears late in the segmentation period in the dorsal midline of the diencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000019", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Anatomical structure which is a medial outgrowth of the thalamus on the dorsal surface of the brain. This structure is light sensitive and secretes melatonin when exposed to prolonged darkness.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010549", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship loss: part_of pineal complex (TAO:0001359)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000019", ontology="TAO"} @@ -228225,11 +332978,11 @@ xref: EV:0100224 xref: FMA:62035 xref: GAID:655 xref: HBA:4518 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=435 xref: MA:0000877 xref: MBA:470 -xref: MESH:A08.186.211.730.385.800.800 +xref: MESH:D020531 xref: NCIT:C12454 +xref: neuronames:435 xref: NLXANAT:1010002 xref: SCTID:361575000 xref: UMLS:C0152355 {source="ncithesaurus:Subthalamic_Nucleus"} @@ -228249,6 +333002,7 @@ id: UBERON:0001908 name: optic tract namespace: uberon def: "Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF]." [NIFSTD, Wikipedia:Optic_tract, ZFIN:curator] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -228267,11 +333021,11 @@ xref: EMAPA:35617 xref: FMA:62046 xref: GAID:735 xref: HBA:9309 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=460 {source="BIRNLEX:1684"} xref: MA:0001099 xref: MBA:125 xref: MESH:D014795 xref: NCIT:C33218 +xref: neuronames:460 {source="BIRNLEX:1684"} xref: SCTID:280952003 xref: TAO:0000252 xref: UMLS:C0152405 {source="BIRNLEX:1684"} @@ -228280,11 +333034,17 @@ xref: VHOG:0001164 xref: Wikipedia:Optic_tract xref: XAO:0004101 xref: ZFA:0000252 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011591 ! tract of diencephalon +relationship: contributes_to_morphology_of UBERON:0003544 ! brain white matter +relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II +relationship: extends_fibers_into UBERON:0000959 ! optic chiasma +relationship: innervates UBERON:0000966 ! retina relationship: part_of UBERON:0002104 ! visual system relationship: part_of UBERON:0003931 ! diencephalic white matter property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png xsd:anyURI property_value: editor_note "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001909 @@ -228311,8 +333071,8 @@ xref: DMBA:17768 xref: EMAPA:37875 {source="MA:th"} xref: FMA:62048 xref: HBA:9227 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=299 {source="BIRNLEX:1609"} xref: MBA:611 +xref: neuronames:299 {source="BIRNLEX:1609"} xref: SCTID:279335009 xref: TAO:0000359 xref: UMLS:C0152363 {source="BIRNLEX:1609"} @@ -228360,11 +333120,18 @@ xref: SCTID:361720005 xref: UMLS:C0929301 {source="ncithesaurus:Mammary_Gland"} xref: VHOG:0000398 xref: Wikipedia:Mammary_gland +is_a: FOODON:03420127 ! animal body or body part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0002530 ! gland +intersection_of: capable_of GO:0007595 ! lactation +relationship: capable_of GO:0007595 ! lactation relationship: develops_from UBERON:0005333 ! mammary bud +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia +relationship: produces UBERON:0001913 ! milk property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg xsd:anyURI property_value: editor_note "Originally this was classified as a female reproductive structure, as it was in the MP in 2011" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl property_value: UBPROP:0000001 "Any of the milk-producing apocrine glands typically occurring in pairs in female mammals and consisting of lobes containing clusters of alveoli with a system of ducts to convey the milk to an external nipple or teat. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000398", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mammary+gland"} property_value: UBPROP:0000003 "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000398", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.224", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "mammary" xsd:string @@ -228395,6 +333162,7 @@ xref: FMA:62090 xref: MA:0000793 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0009911 {source="FMA"} ! lobule +relationship: contributes_to_morphology_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland property_value: editor_note "TODO - ensure correct terminology for lobes/lobules. In mouse there are no distinct lobes (ISBN:0123813611), here lobule appears to be synonymous with acinus" xsd:string @@ -228405,6 +333173,7 @@ namespace: uberon def: "An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim subset: uberon_slim +synonym: "mammal milk" EXACT [] synonym: "mammary gland milk" EXACT [] xref: BTO:0000868 xref: CALOHA:TS-0636 @@ -228416,16 +333185,22 @@ xref: GAID:1230 xref: galen:Milk xref: MA:0002552 xref: MAT:0000056 -xref: MESH:A13.622 +xref: MESH:D008892 xref: MIAA:0000056 xref: NCIT:C13401 xref: OpenCyc:Mx4rvVjGZJwpEbGdrcN5Y29ycA xref: UMLS:C1511310 {source="ncithesaurus:Breast_Fluid_or_Secretion"} xref: VHOG:0001263 xref: Wikipedia:Breast_milk +is_a: ENVO:01000815 ! liquid environmental material +is_a: FOODON:00001257 ! milk or milk based food product +is_a: FOODON:03315150 ! mammalian milk product is_a: UBERON:0006314 ! bodily fluid is_a: UBERON:0006539 ! mammary gland fluid/secretion +relationship: has_part CHEBI:18059 ! lipid +relationship: output_of GO:0007595 ! lactation property_value: editor_note "to axiomatize the different forms of mammary gland secretion an ontology of the phases of pregnancy/lactation is required. Using the existing GO def of lactation is circular." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl property_value: UBPROP:0000003 "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001263", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.224", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "ncit:Milk refers specifically to cow milk" xsd:string {external_ontology="ncit"} @@ -228465,7 +333240,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0006904 xref: MA:0000711 xref: NCIT:C49215 xref: UMLS:C0006904 {source="ncithesaurus:Capillary_Endothelium"} -is_a: UBERON:0004638 ! blood vessel endothelium +is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001982 ! capillary relationship: part_of UBERON:0001982 ! capillary @@ -228482,8 +333257,8 @@ xref: http://linkedlifedata.com/resource/umls/id/C1179024 xref: MA:0000705 xref: NCIT:C49192 xref: UMLS:C1179024 {source="ncithesaurus:Arteriole_Endothelium"} -is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium +is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001980 ! arteriole relationship: part_of UBERON:0001980 ! arteriole @@ -228512,8 +333287,8 @@ intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery property_value: UBPROP:0000001 "The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011013", ontology="AAO", source="XAO:curator"} -property_value: UBPROP:0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001215", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207"} property_value: UBPROP:0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001215", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207", source="http://bgee.unil.ch/"} +property_value: UBPROP:0000003 "Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001215", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207"} [Term] id: UBERON:0001918 @@ -228527,8 +333302,8 @@ xref: http://linkedlifedata.com/resource/umls/id/C1179026 xref: MA:0000716 xref: NCIT:C49319 xref: UMLS:C1179026 {source="ncithesaurus:Venule_Endothelium"} -is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium +is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001979 ! venule relationship: part_of UBERON:0001979 ! venule @@ -228584,9 +333359,9 @@ xref: DHBA:10457 xref: EMAPA:35666 xref: FMA:62152 xref: HBA:4533 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=308 {source="BIRNLEX:764"} xref: MA:0000866 xref: MBA:149 +xref: neuronames:308 {source="BIRNLEX:764"} xref: SCTID:369163000 xref: UMLS:C0175253 {source="BIRNLEX:764"} is_a: UBERON:0015233 ! nucleus of dorsal thalamus @@ -228617,10 +333392,10 @@ xref: EMAPA:35659 xref: EV:0100202 xref: FMA:62166 xref: HBA:4439 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=324 {source="BIRNLEX:952"} xref: MA:0000874 xref: MBA:930 xref: NCIT:C33260 +xref: neuronames:324 {source="BIRNLEX:952"} xref: SCTID:279150008 xref: UMLS:C0228352 {source="ncithesaurus:Parafascicular_Nucleus_of_the_Thalamus"} xref: UMLS:C0228352 {source="BIRNLEX:952"} @@ -228655,9 +333430,9 @@ xref: DHBA:10445 xref: EMAPA:35206 xref: FMA:62171 xref: HBA:4438 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=321 {source="BIRNLEX:971"} xref: MA:0000872 xref: MBA:599 +xref: neuronames:321 {source="BIRNLEX:971"} xref: PBA:128012616 xref: SCTID:279161000 xref: UMLS:C0920328 {source="BIRNLEX:971"} @@ -228696,9 +333471,9 @@ xref: EMAPA:35658 xref: EV:0100204 xref: FMA:62172 xref: HBA:4435 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=322 {source="BIRNLEX:981"} xref: MA:0000873 xref: MBA:907 +xref: neuronames:322 {source="BIRNLEX:981"} xref: SCTID:279152000 xref: UMLS:C0228354 {source="BIRNLEX:981"} is_a: UBERON:0015233 ! nucleus of dorsal thalamus @@ -228739,9 +333514,9 @@ xref: EFO:0001988 xref: EMAPA:35478 xref: EV:0100219 xref: FMA:62209 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=352 {source="BIRNLEX:1662"} xref: MA:0000869 xref: NCIT:C32556 +xref: neuronames:352 {source="BIRNLEX:1662"} xref: PBA:128013070 xref: SCTID:362377006 xref: UMLS:C0086526 {source="BIRNLEX:1662"} @@ -228785,10 +333560,10 @@ xref: EMAPA:35546 xref: EV:0100218 xref: FMA:62211 xref: HBA:12926 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=355 {source="BIRNLEX:1670"} xref: MA:0000870 xref: MBA:475 xref: NCIT:C32843 +xref: neuronames:355 {source="BIRNLEX:1670"} xref: SCTID:362378001 xref: UMLS:C0086596 {source="BIRNLEX:1670"} xref: UMLS:C0086596 {source="ncithesaurus:Internal_Geniculate_Body"} @@ -228831,8 +333606,8 @@ xref: EMAPA:36655 xref: FMA:62313 xref: GAID:644 xref: HBA:4541 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=377 {source="BIRNLEX:1706"} -xref: MESH:A08.186.211.730.385.357.342.450 +xref: MESH:D011301 +xref: neuronames:377 {source="BIRNLEX:1706"} xref: SCTID:362382004 xref: TAO:0000470 xref: UMLS:C0033063 {source="BIRNLEX:1706"} @@ -228877,10 +333652,10 @@ xref: EV:0100227 xref: FMA:62317 xref: GAID:646 xref: HBA:12907 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=385 {source="BIRNLEX:1411"} xref: MA:0000849 xref: MBA:390 -xref: MESH:A08.186.211.730.385.357.342.650 +xref: MESH:D013495 +xref: neuronames:385 {source="BIRNLEX:1411"} xref: SCTID:369130007 xref: UMLS:C0038869 {source="BIRNLEX:1411"} xref: Wikipedia:Supraoptic_nucleus @@ -228927,10 +333702,10 @@ xref: EV:0100229 xref: FMA:62320 xref: GAID:643 xref: HBA:12905 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=387 {source="BIRNLEX:1407"} xref: MA:0000848 xref: MBA:38 -xref: MESH:A08.186.211.730.385.357.342.400 +xref: MESH:D010286 +xref: neuronames:387 {source="BIRNLEX:1407"} xref: SCTID:369131006 xref: UMLS:C0030532 {source="BIRNLEX:1407"} xref: Wikipedia:Paraventricular_nucleus_of_hypothalamus @@ -228949,6 +333724,7 @@ def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [FMA:FMA, http://en.wikipedia.org/wiki/Midbrain_tegmentum, ISBN:0471888893] comment: 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -228975,6 +333751,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/362392007 xref: MA:0000212 xref: MAT:0000452 xref: Midbrain:tegmentum +xref: neuronames:491 {source="BIRNLEX:1200"} xref: SCTID:362392007 xref: TAO:0000160 xref: UMLS:C0039441 {source="BIRNLEX:1200"} @@ -228987,6 +333764,7 @@ relationship: develops_from UBERON:0010285 {source="ZFA"} ! midbrain basal plate relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0002298 ! brainstem property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)"} @@ -228995,6 +333773,7 @@ id: UBERON:0001944 name: pretectal region namespace: uberon def: "Nuclear complex between dorsal thalamus and optic tectum whose nuclei receive afferents primarily from the retina and the optic tectum and are involved in modulating motor behavior in response to visual input." [https://github.com/obophenotype/uberon/issues/361, ISBN:0471888893] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -229018,9 +333797,10 @@ xref: DMBA:16510 xref: EMAPA:32778 xref: FMA:62402 xref: HBA:9079 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=467 {source="BIRNLEX:703"} xref: MA:0001062 xref: MBA:1100 +xref: MESH:D066250 +xref: neuronames:467 {source="BIRNLEX:703"} xref: NLX:59721 xref: SCTID:416333003 xref: TAO:0000418 @@ -229041,6 +333821,7 @@ property_value: RO:0002171 UBERON:0002696 {source="ABA"} property_value: RO:0002171 UBERON:0002722 {source="ABA"} property_value: RO:0002171 UBERON:0002995 {source="ABA"} property_value: RO:0002171 UBERON:0003040 {source="ABA"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light refle[MP:0009637]x" xsd:string {source="MP:0009637"} property_value: UBPROP:0000001 "Region of brain lying between the midbrain tectum and the thalamus (Sefton and Dreher, in Paxinos, G The rat central nervous system, 1995, pg 859), Situated at the level of poterior commissure and just rostral to the superior colliculus (Brodal, Neurological Anatomy, 3rd ed, 1981, pg 542)" xsd:string {source="NLX:59721"} property_value: UBPROP:0000008 "in monotremes, undifferentiated and possesses only a single nucleus[ISBN:0471888893]" xsd:string @@ -229056,6 +333837,7 @@ namespace: uberon def: "Part of the midbrain tecturm consisting of paired bodies that sit caudal to the thalamus and surround the pineal gland in the mesencephalon of vertebrate brains. It comprises the rostral aspect of the midbrain, posterior to the periaqueductal gray and adjacent superior the inferior colliculus. The inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin, quadruplet bodies). It consists of several identified cellular layers and also comprises the brachium of the superior colliculus and commissure of supeior colliculus from Wikipedia.org and Neuronames (MM)." [BIRNLEX:1040] comment: ). In hagfish, lamprey, and shark it is a relatively small structure, but in teleost fish it is greatly expanded, in some cases becoming the largest structure in the brain. (See the adjoining drawing of a codfish brain.) In amphibians, reptiles, and especially birds it is also a very significant component, but in mammals it is dwarfed by the massive expansion of the cerebral cortex. subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -229093,9 +333875,9 @@ xref: EV:0100245 xref: FMA:62403 xref: GAID:576 xref: HBA:9114 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=473 {source="BIRNLEX:1040"} xref: MA:0001068 -xref: MESH:A08.186.211.132.659.237.816 +xref: MESH:D013477 +xref: neuronames:473 {source="BIRNLEX:1040"} xref: TAO:0000445 xref: UMLS:C0228405 {source="BIRNLEX:1040"} xref: Wikipedia:Superior_colliculus @@ -229106,6 +333888,7 @@ is_a: UBERON:0006794 ! visual processing part of nervous system is_a: UBERON:0015212 ! lateral structure relationship: part_of UBERON:0002259 ! corpora quadrigemina property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/da/Cn3nucleus.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The brain structure where the two separate inputs from the two eyes are combined into a single, integrated map.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010609", ontology="AAO", source="PMID:17952453"} property_value: UBPROP:0000001 "The roof of the midbrain, morphologically visible by the end of the segmentation period. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000445", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "The tectum is a layered structure, with a number of layers that vary by species. The superficial layers are sensory-related, and receive input from the eyes as well as other sensory systems.[1] The optic tectum is one of the fundamental components of the vertebrate brain, existing across the full range of species from hagfish to human.[4] (See the brain article for background.) Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic nerve to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish[5]), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow[5]" xsd:string @@ -229117,6 +333900,7 @@ name: inferior colliculus namespace: uberon def: "Part of the midbrain tectum, consisting of paired predominantly gray matter elevations on the dorsal aspect of the midbrain, located caudal to the superior colliculus, dorsal to the periaqueductal gray of the cerebral aqueduct and rostral to the cerebellum. According to Neuronames, the inferior colliculus comprises the central, pericentral and external nucleus and two predominantly white matter structures, the brachium of the inferior colliculus and the commissure of the inferior colliculus (MM)." [BIRNLEX:806] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "caudal colliculus" EXACT [] @@ -229138,22 +333922,24 @@ xref: EV:0100246 xref: FMA:62404 xref: GAID:575 xref: HBA:9102 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=476 {source="BIRNLEX:806"} xref: MA:0001067 xref: MBA:4 -xref: MESH:A08.186.211.132.659.237.364 +xref: MESH:D007245 +xref: neuronames:476 {source="BIRNLEX:806"} xref: UMLS:C0228411 {source="BIRNLEX:806"} xref: Wikipedia:Inferior_colliculus is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0015212 ! lateral structure relationship: part_of UBERON:0002259 ! corpora quadrigemina property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/26/Gray711.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001947 name: red nucleus namespace: uberon def: "Large round nucleus located in the midbrain tegmentum, consisting of a magnocellular and parvicellular portion in most species studied." [BIRNLEX:1478] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus rotundus subthalamo-peduncularis" RELATED LATIN [NeuroNames:505] @@ -229174,10 +333960,10 @@ xref: EV:0100248 xref: FMA:62407 xref: GAID:586 xref: HBA:9053 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=505 {source="BIRNLEX:1478"} xref: MA:0001063 xref: MBA:214 -xref: MESH:A08.186.211.132.659.822.642 +xref: MESH:D012012 +xref: neuronames:505 {source="BIRNLEX:1478"} xref: SCTID:279287006 xref: TAO:0000552 xref: UMLS:C0034910 {source="BIRNLEX:1478"} @@ -229198,6 +333984,7 @@ property_value: RO:0002171 UBERON:0002696 {source="ABA"} property_value: RO:0002171 UBERON:0002722 {source="ABA"} property_value: RO:0002171 UBERON:0002995 {source="ABA"} property_value: RO:0002171 UBERON:0003040 {source="ABA"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "in animals without a significant corticospinal tract, gait is mainly controlled by the red nucleus." xsd:string [Term] @@ -229219,6 +334006,16 @@ intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0001949 +name: gingival epithelium +is_a: UBERON:0002424 ! oral epithelium +is_a: UBERON:0006915 ! stratified squamous epithelium +is_a: UBERON:0035037 ! jaw epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001828 ! gingiva +relationship: part_of UBERON:0001828 ! gingiva + [Term] id: UBERON:0001950 name: neocortex @@ -229248,10 +334045,10 @@ xref: EMAPA:32842 xref: EMAPA:35589 xref: FMA:62429 xref: GAID:677 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 {source="BIRNLEX:2547"} xref: MA:0002754 xref: MBA:315 -xref: MESH:A08.186.211.730.885.213.420 +xref: MESH:D019579 +xref: neuronames:757 {source="BIRNLEX:2547"} xref: PBA:294021746 xref: UMLS:C0175173 {source="BIRNLEX:2547"} xref: Wikipedia:Neocortex @@ -229264,6 +334061,24 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/77/N property_value: RO:0002171 UBERON:0002264 {source="ABA"} property_value: UBPROP:0000003 "The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils" xsd:string {source="PMID:23027930"} +[Term] +id: UBERON:0001951 +name: epithelium of nasopharynx +is_a: UBERON:0003351 ! pharyngeal epithelium +is_a: UBERON:0004814 ! upper respiratory tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx + +[Term] +id: UBERON:0001952 +name: epithelium of oropharynx +is_a: UBERON:0003351 ! pharyngeal epithelium +is_a: UBERON:0004808 ! gastrointestinal system epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx + [Term] id: UBERON:0001954 name: Ammon's horn @@ -229298,15 +334113,15 @@ xref: EMAPA:32845 xref: EV:0100180 xref: FMA:62493 xref: GAID:623 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3157 xref: http://scalablebrainatlas.incf.org/services/thumbnail.php?template=ABA07&size=L&dim=2d3d&format=png®ion=CA xref: MA:0000191 xref: MAT:0000114 xref: MBA:375 -xref: MESH:A08.186.211.577.405 +xref: MESH:D006624 xref: MIAA:0000114 xref: NCIT:C12444 xref: NCIT:C32374 +xref: neuronames:3157 xref: OpenCyc:Mx4rv3piFJwpEbGdrcN5Y29ycA xref: PBA:128012244 xref: SCTID:361561007 @@ -229316,6 +334131,7 @@ xref: VHOG:0001177 xref: Wikipedia:Hippocampus is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000349 {source="FMA"} ! limbic system relationship: part_of UBERON:0002421 {source="ABA"} ! hippocampal formation relationship: part_of UBERON:0002600 {source="FMA"} ! limbic lobe @@ -229325,6 +334141,14 @@ property_value: RO:0002171 UBERON:0002601 {source="ABA"} property_value: UBPROP:0000007 "hippocampal" xsd:string property_value: UBPROP:0000012 "Non-mammalian species do not have a brain structure that looks like the mammalian hippocampus, but they have one that is considered homologous to it. The hippocampus, as pointed out above, is essentially the medial edge of the cortex. Only mammals have a fully developed cortex, but the structure it evolved from, called the pallium, is present in all vertebrates, even the most primitive ones such as the lamprey or hagfish. The pallium is usually divided into three zones: medial, lateral, and dorsal. The medial pallium forms the precursor of the hippocampus. It does not resemble the hippocampus visually, because the layers are not warped into an S shape or enwrapped by the dentate gyrus, but the homology is indicated by strong chemical and functional affinities. There is now evidence that these hippocampal-like structures are involved in spatial cognition in birds, reptiles, and fish. In birds, the correspondence is sufficiently well established that most anatomists refer to the medial pallial zone as the 'avian hippocampus'. The story for fish is more complex. In teleost fish (which make up the great majority of existing species), the forebrain is distorted in comparison to other types of vertebrates: most neuroanatomists believe that the teleost forebrain is essentially everted, like a sock turned inside-out, so that structures that lie in the interior, next to the ventricles, for most vertebrates, are found on the outside in teleost fish, and vice versa. One of the consequences of this is that the medial pallium ('hippocampal' zone) of a typical vertebrate is thought to correspond to the lateral pallium of a typical fish. Several types of fish (particularly goldfish) have been shown experimentally to have strong spatial memory abilities, even forming 'cognitive maps' of the areas they inhabit.[WP]" xsd:string +[Term] +id: UBERON:0001955 +name: epithelium of respiratory bronchiole +is_a: UBERON:0002051 ! epithelium of bronchiole +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002188 ! respiratory bronchiole +relationship: part_of UBERON:0002188 ! respiratory bronchiole + [Term] id: UBERON:0001956 name: cartilage of bronchus @@ -229346,13 +334170,71 @@ xref: NCIT:C49209 xref: SCTID:278980009 xref: UMLS:C0225604 {source="ncithesaurus:Bronchus_Cartilage"} is_a: UBERON:0003603 ! lower respiratory tract cartilage +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: composed_primarily_of UBERON:0001994 {source="MP"} ! hyaline cartilage tissue +relationship: contributes_to_morphology_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus + +[Term] +id: UBERON:0001957 +name: submucosa of bronchus +namespace: uberon +def: "A submucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchi submucosa" EXACT [OBOL:automatic] +synonym: "bronchial submucosa" EXACT [] +synonym: "bronchial trunk submucosa" EXACT [OBOL:automatic] +synonym: "bronchus submucosa" EXACT [] +synonym: "submucosa of bronchi" EXACT [OBOL:automatic] +synonym: "submucosa of bronchial trunk" EXACT [OBOL:automatic] +synonym: "submucous layer of bronchi" RELATED [BTO:0002108] +synonym: "tela submucosa bronchi" EXACT LATIN [FMA:62653, FMA:TA] +xref: BTO:0002108 +xref: EMAPA:37449 {source="MA:th"} +xref: FMA:62653 +xref: MA:0001837 +xref: NCIT:C49214 +xref: SCTID:85546005 +xref: UMLS:C0225601 {source="ncithesaurus:Bronchus_Submucosa"} +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0004777 ! respiratory system submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus +[Term] +id: UBERON:0001958 +name: terminal bronchiole epithelium +namespace: uberon +def: "An epithelium that lines a terminal bronchiole." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas +synonym: "bronchiolus terminalis epithelial tissue" EXACT [OBOL:automatic] +synonym: "bronchiolus terminalis epithelium" EXACT [OBOL:automatic] +synonym: "epithelial tissue of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "epithelial tissue of terminal bronchiole" EXACT [OBOL:automatic] +synonym: "epithelium of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "epithelium of terminal bronchiole" EXACT [FMA:62794] +synonym: "terminal bronchiole epithelial tissue" EXACT [OBOL:automatic] +synonym: "terminal bronchiole epithelium" EXACT [] +xref: EMAPA:36283 +xref: FMA:62794 +xref: MA:0001774 +xref: NCIT:C33755 +xref: UMLS:C1179400 {source="ncithesaurus:Terminal_Bronchiole_Epithelium"} +is_a: UBERON:0002051 ! epithelium of bronchiole +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002187 ! terminal bronchiole +relationship: has_part CL:0000158 {source="FMA"} ! club cell +relationship: part_of UBERON:0002187 ! terminal bronchiole +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" xsd:string + [Term] id: UBERON:0001959 name: white pulp of spleen namespace: uberon def: "The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies." [MGI:csmith, MP:0002357] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "noduli lymphoidei splenici" RELATED LATIN [Wikipedia:White_pulp] @@ -229368,7 +334250,10 @@ xref: NCIT:C12993 xref: UMLS:C0229686 {source="ncithesaurus:Splenic_White_Pulp"} xref: Wikipedia:White_pulp is_a: UBERON:1000023 ! spleen pulp +relationship: composed_primarily_of CL:0000542 ! lymphocyte +relationship: contributes_to_morphology_of UBERON:0002106 ! spleen property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located. [Wikipedia:White_pulp]" xsd:string [Term] @@ -229376,6 +334261,7 @@ id: UBERON:0001960 name: periarterial lymphatic sheath namespace: uberon def: "The area of the spleen in which T cells surround the central arteriole." [MP:0002358] +subset: human_reference_atlas subset: pheno_slim synonym: "PALS" EXACT ABBREVIATION [MP:0002358] synonym: "periarterial lymphoid sheath" EXACT [] @@ -229390,7 +334276,11 @@ is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0010393 ! T cell domain is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0010393 ! T cell domain +intersection_of: part_of UBERON:0001959 ! white pulp of spleen +relationship: contributes_to_morphology_of UBERON:0001959 ! white pulp of spleen relationship: part_of UBERON:0001959 ! white pulp of spleen +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "FMA distinguishes periarterial (PALS) from periarteriolar (FMA:62806)" xsd:string {external_ontology="FMA"} [Term] @@ -229398,6 +334288,7 @@ id: UBERON:0001961 name: mucosa-associated lymphoid tissue namespace: uberon def: "Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]." [Wikipedia:Mucosa-associated_lymphoid_tissue] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "epithelio-lymphoid tissue" EXACT [FMA:62819] @@ -229413,13 +334304,17 @@ xref: NCIT:C12910 xref: UMLS:C0599921 {source="ncithesaurus:Mucosa-Associated_Lymphoid_Tissue"} xref: Wikipedia:Mucosa-associated_lymphoid_tissue is_a: UBERON:0012069 {source="FMA"} ! epithelium-associated lymphoid tissue +relationship: contains_process GO:0046649 ! lymphocyte activation +relationship: overlaps UBERON:0000344 ! mucosa property_value: editor_note "todo - add part relationships to specific layers" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001962 name: gut-associated lymphoid tissue namespace: uberon def: "Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]." [Wikipedia:Gut-associated_lymphoid_tissue] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "GALT" RELATED [] @@ -229429,10 +334324,12 @@ xref: MA:0000136 xref: NCIT:C12936 xref: UMLS:C0596638 {source="ncithesaurus:Gut_Associated_Lymphoid_Tissue"} xref: Wikipedia:Gut-associated_lymphoid_tissue -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract property_value: editor_note "phylogenetic relationships to be added" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "guts of jawless fish contains cells with lymphocyte-like morphology (Mayer 2002)." xsd:string [Term] @@ -229450,6 +334347,9 @@ xref: NCIT:C32234 xref: UMLS:C1179418 {source="ncithesaurus:Bronchus-Associated_Lymphoid_Tissue"} is_a: UBERON:0001961 ! mucosa-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: overlaps UBERON:0001957 ! submucosa of bronchus relationship: part_of UBERON:0002185 ! bronchus [Term] @@ -229480,10 +334380,10 @@ xref: DHBA:12252 xref: EMAPA:35836 xref: FMA:62907 xref: HBA:9074 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 {source="BIRNLEX:990"} xref: MA:0001064 xref: MBA:374 xref: NCIT:C97341 +xref: neuronames:537 {source="BIRNLEX:990"} xref: UMLS:C0175412 {source="BIRNLEX:990"} xref: UMLS:C0175412 {source="ncithesaurus:Pars_Compacta"} xref: Wikipedia:Substantia_nigra_pars_compacta @@ -229526,9 +334426,9 @@ xref: DHBA:12259 xref: EMAPA:35838 xref: FMA:62908 xref: HBA:9075 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 {source="BIRNLEX:968"} xref: MA:0001066 xref: MBA:381 +xref: neuronames:537 {source="BIRNLEX:968"} xref: UMLS:C0175413 {source="BIRNLEX:968"} xref: Wikipedia:Pars_reticulata is_a: UBERON:0000064 ! organ part @@ -229567,7 +334467,11 @@ xref: OpenCyc:Mx4rvgC-zpwpEbGdrcN5Y29ycA xref: UMLS:C1518159 {source="ncithesaurus:Male_Genital_System_Fluid_or_Secretion"} xref: UMLS:C2756969 {source="ncithesaurus:Semen"} xref: Wikipedia:Semen +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000463 ! organism substance +relationship: has_part CL:0000019 ! sperm +relationship: has_part UBERON:0006530 ! seminal fluid +relationship: output_of GO:0042713 ! sperm ejaculation property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/40/Human_semen_in_petri_dish2.jpg xsd:anyURI property_value: UBPROP:0000007 "seminal" xsd:string property_value: UBPROP:0000008 "Note that in this ontology, semen is defined as the sum of sperm and seminal fluid, where seminal fluid is defined in taxonomically generic way (see comments for UBERON:0006530)." xsd:string @@ -229634,6 +334538,14 @@ xref: Wikipedia:Bile xref: ZFA:0005857 is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0002107 ! liver +relationship: capable_of_part_of GO:0007586 ! digestion +relationship: has_part CHEBI:16990 {composition="0.3% in humans"} ! bilirubin IXalpha +relationship: has_part CHEBI:22868 ! bile salt +relationship: has_part CHEBI:36277 ! bile acid salt +relationship: has_quality PATO:0001735 ! liquid configuration +relationship: produced_by UBERON:0002107 ! liver property_value: UBPROP:0000008 "In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum." xsd:string property_value: UBPROP:0000009 "aids the process of digestion of lipids in the small intestine" xsd:string property_value: UBPROP:0000009 "bile salts function to emulsify dietary fats and facilitate their intestinal absorption" xsd:string @@ -229795,12 +334707,31 @@ relationship: part_of UBERON:0002469 {source="FMA"} ! esophagus mucosa property_value: editor_note "TODO check epithelium types: in FMA: Nonkeratinizing stratified squamous epithelium; mouse has basal and squamous subtypes; in ZFA it is columnar" xsd:string property_value: UBPROP:0000001 "Simple columnar epithelium that lines the esophagus. Chen et al, 2007.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001499", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0001978 +name: parenchyma of pancreas +namespace: uberon +subset: human_reference_atlas +synonym: "pancreas parenchyma" EXACT [] +synonym: "pancreatic parenchyma" EXACT [] +xref: EMAPA:32925 +xref: FMA:63120 +xref: MA:0000724 +xref: SCTID:371401008 +xref: VHOG:0001430 +is_a: UBERON:0000353 ! parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0001979 name: venule namespace: uberon def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MESH:A07.231.432.952, MP:0004125] def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." [MESH:A07.231.432.952, MP:0004125] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -229814,6 +334745,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0042520 xref: http://www.snomedbrowser.com/Codes/Details/341687009 xref: MA:0000071 xref: MESH:A07.231.432.952 +xref: MESH:D014699 xref: NCIT:C12818 xref: SCTID:341687009 xref: TAO:0005315 @@ -229822,9 +334754,12 @@ xref: VHOG:0001765 xref: Wikipedia:Venule xref: ZFA:0005315 is_a: UBERON:0003920 ! venous blood vessel +is_a: UBERON:8410081 ! blood microvessel relationship: connects UBERON:0001638 ! vein relationship: connects UBERON:0001982 ! capillary +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg xsd:anyURI property_value: depicted:by Illu:capillary.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005315", ontology="TAO", source="ZFIN:curator"} [Term] @@ -229854,12 +334789,14 @@ xref: VHOG:0001763 xref: Wikipedia:Arteriole xref: ZFA:0005255 is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel +is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: connects UBERON:0001637 ! artery intersection_of: connects UBERON:0001982 ! capillary relationship: connects UBERON:0001637 ! artery relationship: connects UBERON:0001982 ! capillary relationship: contributes_to_morphology_of UBERON:0001637 ! artery +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg xsd:anyURI property_value: depicted:by Illu:capillary.jpg xsd:anyURI property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002138", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Small, terminal branch of an artery which generally connects to capillaries.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010253", ontology="AAO", source="AAO:BJB"} @@ -229907,7 +334844,6 @@ xref: VHOG:0001250 xref: Wikipedia:Blood_vessel xref: XAO:0001011 xref: ZFA:0005314 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: capable_of_part_of GO:0008015 ! blood circulation @@ -229935,6 +334871,7 @@ namespace: uberon def: "Any of the smallest blood vessels connecting arterioles with venules." [http://en.wikipedia.org/wiki/Capillary, https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584] def: "Any of the smallest blood vessels connecting arterioles with venules." [https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584, Wikipedia:Capillary] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -229951,6 +334888,7 @@ xref: http://en.wikipedia.org/wiki/Capillary xref: http://linkedlifedata.com/resource/umls/id/C0935624 xref: MA:0000065 xref: MESH:A07.231.432.410 +xref: MESH:D002196 xref: NCIT:C12685 xref: NLXANAT:090902 xref: OpenCyc:Mx4rvWEU-5wpEbGdrcN5Y29ycA @@ -229960,15 +334898,19 @@ xref: VHOG:0001253 xref: Wikipedia:Capillary xref: XAO:0000116 xref: ZFA:0005250 -is_a: UBERON:0001981 {source="FMA", source="MA", source="XAO"} ! blood vessel -is_a: UBERON:0010523 {source="ZFA"} ! microcirculatory vessel +is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel +intersection_of: UBERON:8410081 ! blood microvessel intersection_of: connects UBERON:0001979 ! venule +intersection_of: connects UBERON:0001979 ! venule +intersection_of: connects UBERON:0001980 ! arteriole intersection_of: connects UBERON:0001980 ! arteriole relationship: connects UBERON:0001979 ! venule relationship: connects UBERON:0001980 ! arteriole property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg xsd:anyURI property_value: editor_note "not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element" xsd:string +property_value: RO:0002175 NCBITaxon:9606 +property_value: seeAlso https://github.com/obophenotype/uberon/issues/2186 xsd:string property_value: UBPROP:0000001 "Any of the tiny blood vessels connecting the arterioles to the venules.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010252", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001253", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001253", ontology="VHOG", source="http://bgee.unil.ch/", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)"} @@ -230033,6 +334975,7 @@ name: corneal endothelium namespace: uberon def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [http://en.wikipedia.org/wiki/Corneal_endothelium] def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [Wikipedia:Corneal_endothelium] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -230064,6 +335007,7 @@ relationship: adjacent_to UBERON:0001766 ! anterior chamber of eyeball relationship: contributes_to_morphology_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001986 @@ -230073,6 +335017,7 @@ def: "A layer of epithelium that lines the heart, blood vessels (endothelium, va def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." [FMA:63916, https://github.com/obophenotype/uberon/issues/225, MESH:A10.272.491] comment: The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) subset: efo_slim +subset: human_reference_atlas subset: uberon_slim xref: BTO:0000393 xref: CALOHA:TS-0278 @@ -230092,7 +335037,8 @@ is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: composed_primarily_of CL:0000115 ! endothelial cell relationship: composed_primarily_of CL:0000115 ! endothelial cell -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "endothelial" xsd:string [Term] @@ -230102,6 +335048,7 @@ namespace: uberon def: "Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell." [http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm, Wikipedia:Placenta] comment: Marsupials possess only a rudimentary yolk-type placenta, with reduced nutrient and oxygen exchanging capabilities. subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -230116,7 +335063,7 @@ xref: FMA:63934 xref: GAID:379 xref: MA:0000386 xref: MAT:0000279 -xref: MESH:A16.759 +xref: MESH:D010920 xref: MIAA:0000279 xref: NCIT:C13272 xref: OpenCyc:Mx4rvv4zZ5wpEbGdrcN5Y29ycA @@ -230130,10 +335077,12 @@ is_a: UBERON:0005156 ! reproductive structure relationship: develops_from UBERON:0000995 {source="ISBN:0073040584"} ! uterus relationship: develops_from UBERON:0003124 {source="Wikipedia"} ! chorion membrane relationship: develops_from UBERON:0004340 {source="ISBN:0073040584"} ! allantois +relationship: only_in_taxon NCBITaxon:32525 {source="https://github.com/obophenotype/uberon/issues/1376"} ! Theria relationship: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0016887 ! entire extraembryonic component property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/66/Placenta.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f1/Placenta.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Phylogenetic analyses of the concatenated data set using maximum parsimony, maximum likelihood and distance based (neighbour joining) methods all converged on a nearly identical, well supported topology defining four principal eutherian lineages. The results affirm monophyly of traditional placental orders (except Artiodactyla and Insectivora), and also support some previously proposed, as well as new, superordinal clades.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001266", ontology="VHOG", source="DOI:10.1038/35054550 Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, O'Brien SJ, Molecular phylogenetics and the origins of placental mammals. Nature (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "placental" xsd:string property_value: UBPROP:0000008 "Eutherians: In eutherians, the chorioallantoic membrane of the fetus establishes intimate contact with the adjacent vascular wall of the mother's uterus to produce the placenta, a composite structure formed in part from tissues of the fetus and in part from tissues of the mother [ISBN:0073040584 (Vertebrates, Kardong)]. TODO - is taxon restriction too strict, even if we restrict def to allantoic placenta? - WP says: also found in some snakes and lizards with varying levels of development up to mammalian levels. Pough et al. 1992. Herpetology: Third Edition. Pearson Prentice Hall:Pearson Education, Inc., 2002. // See also: DOI:10.1002/jmor.11011" xsd:string @@ -230169,6 +335118,7 @@ synonym: "ordure" RELATED [] synonym: "partie de la merde@fr" EXACT [] synonym: "piece of shit" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/23285307] synonym: "piece of shit" EXACT [PMID:23285307] +synonym: "porción de mierda@en" EXACT [] synonym: "porción de mierda@es" EXACT [] synonym: "portion of dung" NARROW [] synonym: "portion of excrement" EXACT [] @@ -230202,6 +335152,9 @@ xref: OpenCyc:Mx4rvVjJMZwpEbGdrcN5Y29ycA xref: UMLS:C0015733 {source="ncithesaurus:Feces"} xref: Wikipedia:Feces is_a: UBERON:0000174 ! excreta +intersection_of: UBERON:0000174 ! excreta +intersection_of: output_of GO:0030421 ! defecation +relationship: output_of GO:0030421 ! defecation property_value: UBPROP:0000001 "Excretion in semisolid state processed by the intestine.[FMA]" xsd:string {source="FMA:64183"} property_value: UBPROP:0000007 "fecal" xsd:string @@ -230361,6 +335314,7 @@ xref: VSAO:0000094 xref: Wikipedia:Hyaline_cartilage xref: XAO:0004029 is_a: UBERON:0002418 {source="FMA"} ! cartilage tissue +relationship: composed_primarily_of GO:0005585 {source="VSAO-text-def"} ! collagen type II trimer property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray292.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg xsd:anyURI property_value: UBPROP:0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel with a perichondrium[FMA:64783]." xsd:string {source="FMA:64783"} @@ -230379,6 +335333,7 @@ synonym: "stratified cartilage tissue" EXACT [http://orcid.org/0000-0002-6601-21 xref: FMA:64784 xref: galen:Fibrocartilage xref: MA:0000108 +xref: MESH:D051445 xref: NCIT:C32599 xref: SCTID:91685003 xref: UMLS:C0684077 {source="ncithesaurus:Fibrocartilage"} @@ -230386,6 +335341,7 @@ xref: VSAO:0000103 xref: Wikipedia:Fibrocartilage xref: XAO:0004028 is_a: UBERON:0002418 ! cartilage tissue +relationship: has_part GO:0005584 ! collagen type I trimer property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray295.png xsd:anyURI property_value: UBPROP:0000001 "A mixture of white fibrous tissue and cartilaginous tissue in various proportions. It owes its flexibility and toughness to the former of these constituents, and its elasticity to the latter. It is the only type of cartilage that contains type I collagen in addition to the normal type I[Wikipedia:Fibrocartilage]I" xsd:string {source="Wikipedia:Fibrocartilage"} property_value: UBPROP:0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which is an amorphous gel without a well-defined perichondrium[FMA:64784]." xsd:string {source="FMA:64784"} @@ -230415,6 +335371,8 @@ xref: Wikipedia:Elastic_cartilage xref: XAO:0004197 is_a: UBERON:0011589 {source="VSAO"} ! non-mineralized cartilage tissue relationship: develops_from UBERON:0005863 {source="VSAO"} ! cartilaginous condensation +relationship: has_part GO:0071953 ! elastic fiber +relationship: has_quality PATO:0001544 ! flexible property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray904.png xsd:anyURI property_value: UBPROP:0000001 "Cartilage (tissue) which consists of chondrocytes and collagen, the intercellular matrix of which consists of elastic fibers[FMA:64785]." xsd:string {source="FMA:64785"} property_value: UBPROP:0000001 "Cartilage tissue that is flexible and contains abundant elastic fibers.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000091", ontology="VSAO", source="PSPUB:0000170"} @@ -230449,10 +335407,10 @@ xref: EHDAA2:0001228 xref: EHDAA:4774 xref: EMAPA:17606 xref: FMA:64803 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1900 {source="BIRNLEX:2703"} xref: MA:0001325 xref: MAT:0000445 xref: NCIT:C33203 +xref: neuronames:1900 {source="BIRNLEX:2703"} xref: SCTID:37623003 xref: TAO:0000554 xref: UMLS:C0599332 {source="BIRNLEX:2703"} @@ -230462,9 +335420,15 @@ xref: Wikipedia:Olfactory_epithelium xref: ZFA:0000554 is_a: UBERON:0005384 ! nasal cavity epithelium is_a: UBERON:0006934 ! sensory epithelium +intersection_of: UBERON:0006934 ! sensory epithelium +intersection_of: part_of UBERON:0005386 ! olfactory segment of nasal mucosa +relationship: capable_of_part_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: contributes_to_morphology_of UBERON:0005725 ! olfactory system +relationship: has_part CL:0000207 ! olfactory receptor cell relationship: immediate_transformation_of UBERON:2001431 ! primitive olfactory epithelium relationship: part_of UBERON:0000012 {source="NIFSTD"} ! somatic nervous system relationship: part_of UBERON:0005386 ! olfactory segment of nasal mucosa +relationship: site_of GO:0022008 ! neurogenesis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray857.png xsd:anyURI property_value: UBPROP:0000001 "Sensory lining of the medial wall, roof and anterior aspects of the main olfactory cavity (cavum principale).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010158", ontology="AAO", source="AAO:DSM"} property_value: UBPROP:0000002 "relationship loss: part_of principal cavity (AAO:0000992)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010158", ontology="AAO"} @@ -230531,6 +335495,9 @@ xref: SCTID:263314001 xref: UMLS:C1261194 {source="ncithesaurus:Joint_of_the_Rib"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000982 ! skeletal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002228 ! rib +relationship: connects UBERON:0002228 ! rib relationship: part_of UBERON:0014478 {source="cjm"} ! rib skeletal system [Term] @@ -230572,6 +335539,7 @@ id: UBERON:0002006 name: cortex of lymph node namespace: uberon def: "Peripheral portion of the lymph node, underneath the capsule[WP]." [Wikipedia:Cortex_of_lymph_node] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex nodi lymphoidei" RELATED LATIN [Wikipedia:Cortex_of_lymph_node] @@ -230584,14 +335552,19 @@ xref: UMLS:C0933402 {source="ncithesaurus:Lymph_Node_Cortex"} xref: Wikipedia:Cortex_of_lymph_node is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001851 ! cortex +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: adjacent_to UBERON:0002194 ! capsule of lymph node relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002007 name: medulla of lymph node namespace: uberon def: "The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lymph_node#Medulla] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lymph node medulla" EXACT [] @@ -230601,7 +335574,29 @@ xref: FMA:66254 xref: MA:0000745 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000958 ! medulla of organ +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: has_part UBERON:0009744 ! lymph node medullary sinus +relationship: has_part UBERON:0009745 ! lymph node medullary cord relationship: part_of UBERON:0000029 ! lymph node +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002008 +name: cardiac nerve plexus +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0001816 ! autonomic nerve plexus +intersection_of: UBERON:0001816 ! autonomic nerve plexus +intersection_of: innervates UBERON:0000948 ! heart +relationship: innervates UBERON:0000948 ! heart + +[Term] +id: UBERON:0002011 +name: thoracodorsal artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001112 ! latissimus dorsi muscle +relationship: supplies UBERON:0001112 ! latissimus dorsi muscle [Term] id: UBERON:0002012 @@ -230609,6 +335604,7 @@ name: pulmonary artery namespace: uberon def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pulmonary_artery] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria pulmonalis" RELATED LATIN [Wikipedia:Pulmonary_artery] @@ -230648,7 +335644,8 @@ relationship: develops_from UBERON:0003123 {source="EHDAA2", source="XAO"} ! pha relationship: develops_from UBERON:0005339 {source="EHDAA2"} ! outflow tract pulmonary component relationship: part_of UBERON:0008886 ! pulmonary vascular system relationship: supplies UBERON:0002048 ! lung -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Major artery which supplies blood to the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010221", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000982", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+artery"} property_value: UBPROP:0000003 "On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000982", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} @@ -230660,6 +335657,7 @@ name: kidney capsule namespace: uberon def: "the tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage" [MGI:anna, MP:0011383] def: "The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage." [MGI:anna, MP:0011383] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "capsula fibrosa renis" EXACT LATIN [FMA:66610, FMA:TA] @@ -230685,7 +335683,9 @@ intersection_of: bounding_layer_of UBERON:0002113 ! kidney relationship: bounding_layer_of UBERON:0002113 ! kidney relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg xsd:anyURI property_value: depicted:by Illu:kidney.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "provides some protection from trauma and damage." xsd:string property_value: UBPROP:0000010 "The renal capsule relates to the other layers in the following order (moving from innermost to outermost): renal medulla renal cortex renal capsule perinephric fat (or 'perirenal fat') renal fascia paranephric fat (or 'pararenal fat') peritoneum (anteriorly), and transversalis fascia (posteriorly).[Wikipedia:Kidney_capsule]" xsd:string @@ -230694,6 +335694,7 @@ id: UBERON:0002016 name: pulmonary vein namespace: uberon def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." [GO:0060577] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pulmonary venous tree organ part" EXACT [] @@ -230720,10 +335721,12 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0002048 ! lung +relationship: connected_to UBERON:0002079 ! left cardiac atrium relationship: develops_from UBERON:0002061 ! truncus arteriosus relationship: drains UBERON:0002048 ! lung relationship: part_of UBERON:0008886 ! pulmonary vascular system -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010521", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001133", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+vein"} property_value: UBPROP:0000001 "the veins that return oxygenated blood from the lungs to the left atrium of the heart" xsd:string {source="MP:0002726,MGI:cwg"} @@ -230735,6 +335738,7 @@ id: UBERON:0002017 name: portal vein namespace: uberon def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." [BTO:0001792] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "portal venous tree organ part" EXACT [FMA:66645] @@ -230757,49 +335761,7 @@ xref: XAO:0000392 is_a: UBERON:0001638 {source="FMA"} ! vein relationship: part_of UBERON:0005806 ! portal system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png xsd:anyURI - -[Term] -id: UBERON:0002018 -name: synovial membrane of synovial joint -namespace: uberon -def: "Soft tissue that lines the non-cartilaginous surfaces within joints with cavities (synovial joints)." [Wikipedia:Synovial_membrane] -subset: efo_slim -subset: uberon_slim -synonym: "membrana synovialis (capsula articularis)" EXACT LATIN [FMA:9865, FMA:TA] -synonym: "membrana synovialis capsulae articularis" EXACT LATIN [Wikipedia:Synovial_membrane] -synonym: "stratum synoviale" EXACT LATIN [FMA:66762, FMA:TA] -synonym: "stratum synoviale (capsula articularis)" EXACT LATIN [FMA:9865, FMA:TA] -synonym: "synovial layer" BROAD [FMA:66762] -synonym: "synovial layer of articular capsule of synovial joint" RELATED [FMA:9865] -synonym: "synovial membrane" BROAD [AEO:0000181] -synonym: "synovial membrane of articular capsule of synovial joint" RELATED [FMA:9865] -synonym: "synovium" BROAD [BTO:0001823, VHOG:0001282] -synonym: "synovium of articular capsule of synovial joint" RELATED [FMA:9865] -xref: AEO:0000181 -xref: BTO:0001823 -xref: EFO:0001393 -xref: EHDAA2_RETIRED:0003181 -xref: EMAPA:37476 {source="MA:th"} -xref: EV:0100143 -xref: FMA:9865 -xref: GAID:264 -xref: galen:SynovialMembrane -xref: MA:0000114 -xref: MESH:D013583 -xref: NCIT:C12473 -xref: SCTID:361828005 -xref: UMLS:C0039099 {source="ncithesaurus:Synovial_Membrane"} -xref: VHOG:0001282 -xref: Wikipedia:Synovial_membrane -is_a: UBERON:0006915 ! stratified squamous epithelium -is_a: UBERON:0007616 {source="FMA"} ! layer of synovial tissue -is_a: UBERON:0012275 ! meso-epithelium -relationship: attaches_to UBERON:0001484 {source="GAID"} ! articular capsule -relationship: has_part CL:0000214 ! synovial cell -relationship: part_of UBERON:0002217 {source="EHDAA2"} ! synovial joint -property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png xsd:anyURI -property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5d/Synovium.png xsd:anyURI -property_value: UBPROP:0000003 "Phylogenetically, synovium is one of the newer attributes of the vertebrate locomotor apparatus. The first synovial joints developed in the piscine jaw of ancestors of modern lungfish by an evolutionary process that modified preexisting fibrous and cartilaginous joints, which were the predominant articulation of the early sea- and land-dwelling vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001282", ontology="VHOG", source="PMID:11068553 O'Connel JX, Pathology of the synovium. American Journal of Clinical Pathology (2000)", source="http://bgee.unil.ch/"} +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002019 @@ -230835,11 +335797,11 @@ xref: FMA:6720 xref: FMA:80284 xref: GAID:825 xref: HBA:9340 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2085 xref: MA:0001088 xref: MBA:717 xref: MESH:D000055 xref: NCIT:C32041 +xref: neuronames:2085 xref: OpenCyc:Mx4rwTEwI5wpEbGdrcN5Y29ycA xref: SCTID:362469008 xref: UMLS:C0000905 {source="ncithesaurus:Accessory_Nerve"} @@ -230890,7 +335852,9 @@ xref: HBA:4006 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2869 xref: http://linkedlifedata.com/resource/umls/id/C0018220 xref: MA:0001112 +xref: MESH:D066128 xref: NCIT:C32695 +xref: neuronames:2869 xref: OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA xref: TAO:0002197 xref: UMLS:C0018220 {source="ncithesaurus:Gray_Matter"} @@ -230899,6 +335863,7 @@ xref: Wikipedia:Gray_matter xref: ZFA:0001681 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: composed_primarily_of GO:0043025 ! neuronal cell body +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: depicted:by Spinal:nerve.svg xsd:anyURI property_value: UBPROP:0000001 "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002197", ontology="TAO", source="ZFIN:curator"} @@ -230907,7 +335872,9 @@ id: UBERON:0002021 name: occipital lobe namespace: uberon def: "Posterior part of the cerebral hemisphere (MSH)." [BIRNLEX:1136] +comment: In some species, parcellations of lobes are not well defined or at all, and therefore the occipital lobe could refer to the most posterior mammalian cerebral cortex. subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lobus occipitalis" RELATED LATIN [Wikipedia:Occipital_lobe] @@ -230923,23 +335890,29 @@ xref: EV:0100170 xref: FMA:67325 xref: GAID:678 xref: HBA:4180 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=140 {source="BIRNLEX:1136"} xref: MAT:0000507 -xref: MESH:A08.186.211.730.885.213.571 +xref: MESH:D009778 xref: NCIT:C12355 +xref: neuronames:140 {source="BIRNLEX:1136"} xref: OpenCyc:Mx4rv9OFy5wpEbGdrcN5Y29ycA xref: SCTID:180923002 xref: UMLS:C0028785 {source="BIRNLEX:1136"} xref: UMLS:C0028785 {source="ncithesaurus:Occipital_Lobe"} xref: Wikipedia:Occipital_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere +relationship: adjacent_to UBERON:0001871 ! temporal lobe +relationship: adjacent_to UBERON:0001872 ! parietal lobe +relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon +relationship: part_of UBERON:0000956 ! cerebral cortex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray727_occipital_lobe.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002025 name: stratum basale of epidermis namespace: uberon def: "The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells." [ISBN:0-683-40008-8, MP:0001231] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "basal cell layer of epidermis" EXACT [FMA:67540] @@ -230973,7 +335946,6 @@ xref: UMLS:C0221925 {source="ncithesaurus:Stratum_Basale"} xref: Wikipedia:Stratum_germinativum xref: XAO:0000041 xref: ZFA:0001180 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer @@ -230983,6 +335955,7 @@ relationship: composed_primarily_of CL:0002187 ! basal cell of epidermis relationship: has_part CL:0000148 ! melanocyte relationship: has_part CL:0000242 ! Merkel cell relationship: part_of UBERON:0001003 ! skin epidermis +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "replaces damaged cells on outside of body" xsd:string property_value: UBPROP:0000010 "consisting of non-keratinized, viable cells, in contrast to the outer (upper) layer of epidermis made up of keratinized, anucleated, non-viable cells" xsd:string @@ -230991,6 +335964,7 @@ id: UBERON:0002026 name: stratum spinosum of epidermis namespace: uberon def: "The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance." [ISBN:0-683-40008-8, MP:0001236] +subset: human_reference_atlas subset: pheno_slim synonym: "epidermis prickle cell layer" RELATED [] synonym: "epidermis stratum spinosum" EXACT [] @@ -231010,7 +335984,14 @@ xref: UMLS:C0221924 {source="ncithesaurus:Stratum_Spinosum"} xref: Wikipedia:Stratum_spinosum is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer +intersection_of: UBERON:0013754 ! integumentary system layer +intersection_of: composed_primarily_of CL:0000649 ! prickle cell +relationship: adjacent_to UBERON:0002025 ! stratum basale of epidermis +relationship: adjacent_to UBERON:0002069 ! stratum granulosum of epidermis +relationship: composed_primarily_of CL:0000649 ! prickle cell +relationship: has_part CL:0000453 ! Langerhans cell relationship: part_of UBERON:0001003 ! skin epidermis +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "Has cells that produce and secrete bipolar lipids which prevent evaporation, helping to 'water-proof' the skin. Keratinization begins in the stratum spinosum. [Wikipedia:Stratum_spinosum]" xsd:string [Term] @@ -231018,6 +335999,7 @@ id: UBERON:0002027 name: stratum corneum of epidermis namespace: uberon def: "The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells." [ISBN:0-683-40008-8, MP:0001240] +subset: human_reference_atlas subset: pheno_slim synonym: "cornified layer" EXACT [] synonym: "epidermis stratum corneum" EXACT [] @@ -231039,8 +336021,11 @@ xref: UMLS:C0221921 {source="ncithesaurus:Stratum_Corneum"} xref: Wikipedia:Stratum_corneum is_a: UBERON:0003055 ! periderm is_a: UBERON:0013754 ! integumentary system layer -property_value: depicted:by Epidermal:layers.png xsd:anyURI +relationship: contains_process GO:0031424 ! keratinization +relationship: superficial_to UBERON:0002069 ! stratum granulosum of epidermis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Skinlayers.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/e/e4/Epidermal_layers.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The keratinized outermost layer of the epidermis, which is periodically shed.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010597", ontology="AAO", source="AAO:CAM"} property_value: UBPROP:0000010 "some oral epitehlium also has cornified layer / stratum corneum" xsd:string @@ -231051,6 +336036,7 @@ namespace: uberon def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [http://en.wikipedia.org/wiki/Rhombencephalon, ZFA:0000029, ZFIN:curator] def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [Wikipedia:Rhombencephalon, ZFA:0000029, ZFIN:curator] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -231080,6 +336066,7 @@ xref: MBA:1065 xref: MESH:D012249 xref: MIAA:0000107 xref: NCIT:C40336 +xref: neuronames:540 {source="BIRNLEX:942"} xref: SCTID:303456008 xref: TAO:0000029 xref: UMLS:C0035507 {source="ncithesaurus:Hind-Brain"} @@ -231101,6 +336088,7 @@ property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", sourc property_value: RO:0002171 UBERON:0001894 {source="ABA"} property_value: RO:0002175 NCBITaxon:7762 {source="PMID:8932866"} property_value: RO:0002175 NCBITaxon:7762 {source="http://www.ncbi.nlm.nih.gov/pubmed/8932866"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010150", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000029", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000029", ontology="TAO"} @@ -231132,6 +336120,9 @@ xref: NCIT:C49227 xref: UMLS:C1180206 {source="ncithesaurus:Gallbladder_Epithelium"} is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: contributes_to_morphology_of UBERON:0002110 ! gall bladder relationship: part_of UBERON:0002110 ! gall bladder [Term] @@ -231164,6 +336155,7 @@ xref: Wikipedia:Nipple is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0004121 ! ectoderm-derived structure relationship: develops_from UBERON:0008425 {source="Stedmans"} ! mammary ridge +relationship: only_in_taxon NCBITaxon:32525 ! Theria property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/59/Female_nipple_profile.jpg xsd:anyURI property_value: UBPROP:0000008 "a male mouse has no nipples - mammary tissue regresses during embryonic development" xsd:string property_value: UBPROP:0000012 "FMA makes this part of the breast, whereas in MA it is part of the mammary gland -" xsd:string {external_ontology="FMA"} @@ -231196,6 +336188,10 @@ xref: MA:0001839 xref: NCIT:C32231 xref: UMLS:C0599333 {source="ncithesaurus:Bronchial_Epithelium"} is_a: UBERON:0008397 ! tracheobronchial epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: contributes_to_morphology_of UBERON:0002185 ! bronchus +relationship: has_part CL:0002209 {source="FMA"} ! intermediate epitheliocyte relationship: part_of UBERON:0002185 ! bronchus [Term] @@ -231216,8 +336212,8 @@ xref: Wikipedia:Areola is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034929 ! external soft tissue zone relationship: part_of UBERON:0001911 {source="MA"} ! mammary gland -property_value: depicted:by Female:Areola.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f4/Brustwarze.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/ad/Female_Areola.jpg xsd:anyURI property_value: UBPROP:0000007 "areolar" xsd:string [Term] @@ -231244,7 +336240,9 @@ xref: FMA:67821 xref: MA:0000778 xref: SCTID:319910005 xref: Wikipedia:Arrector_pili_muscle +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001135 {source="FMA"} ! smooth muscle tissue +relationship: attaches_to UBERON:0002073 ! hair follicle relationship: part_of UBERON:0011932 {source="FMA"} ! pilosebaceous unit property_value: UBPROP:0000009 "When contracted the arrector pili causes the raising of the hair" xsd:string @@ -231278,11 +336276,11 @@ xref: EV:0100228 xref: FMA:67883 xref: GAID:645 xref: HBA:12908 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=384 {source="BIRNLEX:1325"} xref: MA:0000843 xref: MBA:286 -xref: MESH:A08.186.211.730.385.357.342.625 +xref: MESH:D013493 xref: NCIT:C74537 +xref: neuronames:384 {source="BIRNLEX:1325"} xref: SCTID:369132004 xref: TAO:0000441 xref: UMLS:C0038866 {source="ncithesaurus:Suprachiasmatic_Nucleus"} @@ -231338,6 +336336,7 @@ name: cerebellum namespace: uberon def: "Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]." [BTO:0000232, https://sourceforge.net/tracker/index.php?func=detail&aid=3291162&group_id=76834&atid=1205376, ISBN:3764351209, MESH:A08.186.211.132.810.428.200, ZFA:0000100] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -231360,13 +336359,13 @@ xref: EV:0100293 xref: FMA:67944 xref: GAID:595 xref: HBA:4696 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643 {source="BIRNLEX:1489"} xref: MA:0000198 xref: MAT:0000110 xref: MBA:512 xref: MESH:D002531 xref: MIAA:0000110 xref: NCIT:C12445 +xref: neuronames:643 {source="BIRNLEX:1489"} xref: OpenCyc:Mx4rvl1eipwpEbGdrcN5Y29ycA xref: SCTID:180924008 xref: TAO:0000100 @@ -231379,14 +336378,18 @@ xref: XAO:0003098 xref: ZFA:0000100 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: capable_of NBO:0000347 ! gross motor coordination +relationship: contributes_to_morphology_of UBERON:0001895 ! metencephalon relationship: develops_from UBERON:0006215 {evidence="definitional"} ! rhombic lip +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001895 {source="FMA", source="MA"} ! metencephalon -property_value: depicted:by Cerebellum:NIH.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png xsd:anyURI property_value: RO:0002161 NCBITaxon:117565 {source="ISBN:0471888893"} property_value: RO:0002171 UBERON:0001893 {source="ABA"} property_value: RO:0002171 UBERON:0002298 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"} property_value: RO:0002174 NCBITaxon:117569 {source="http://icb.oxfordjournals.org/content/42/4/743.full"} property_value: RO:0002175 NCBITaxon:117569 {source="ISBN:0471888893"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010485", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000100", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000024", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005)", source="http://bgee.unil.ch/"} @@ -231400,6 +336403,7 @@ name: substantia nigra namespace: uberon def: "Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM)." [BIRNLEX:789] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "nucleus of basis pedunculi" EXACT [] @@ -231420,11 +336424,11 @@ xref: EV:0100247 xref: FMA:67947 xref: GAID:581 xref: HBA:9072 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=536 {source="BIRNLEX:789"} xref: MA:0000210 xref: MAT:0000504 -xref: MESH:A08.186.211.132.659.687 +xref: MESH:D013378 xref: NCIT:C12453 +xref: neuronames:536 {source="BIRNLEX:789"} xref: SCTID:279286002 xref: UMLS:C0038590 {source="BIRNLEX:789"} xref: UMLS:C0038590 {source="ncithesaurus:Substantia_Nigra"} @@ -231435,6 +336439,7 @@ is_a: UBERON:0009661 ! midbrain nucleus relationship: part_of UBERON:0002420 {source="NIF"} ! basal ganglion property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Midbraincrosssection.png xsd:anyURI property_value: editor_note "TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Subdivision of the midbrain anterior to the midbrain tegmentum which contains darkly pigmented neurons[FMA][FMA:67947]." xsd:string {source="FMA:67947"} property_value: UBPROP:0000003 "(...) the substantia nigra first appears in reptiles and is best developed in primates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001573", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.336", source="http://bgee.unil.ch/"} @@ -231444,6 +336449,7 @@ name: bronchial artery namespace: uberon def: "A systemic artery that supplies the lung with with oxygenated blood." [UBERON:cjm, Wikipedia:Bronchial_artery] comment: Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. +subset: human_reference_atlas subset: uberon_slim synonym: "arteriae bronchiales" RELATED LATIN [Wikipedia:Bronchial_artery] synonym: "bronchial arterial tree" EXACT [] @@ -231464,12 +336470,14 @@ intersection_of: part_of UBERON:0004571 ! systemic arterial system intersection_of: supplies UBERON:0002048 ! lung relationship: supplies UBERON:0002048 ! lung property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002042 name: lymphatic vessel endothelium namespace: uberon def: "An endothelium that is part of a lymphatic vessel [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "endothelium of lymph vessel" EXACT [OBOL:automatic] @@ -231488,7 +336496,11 @@ xref: TAO:0005258 xref: UMLS:C1180786 {source="ncithesaurus:Lymphatic_Vessel_Endothelium"} xref: ZFA:0005258 is_a: UBERON:0004852 ! cardiovascular system endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0001473 ! lymphatic vessel +relationship: contributes_to_morphology_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The vascular endothelium that lines the lymph vessels.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005258", ontology="TAO", source="ZFIN:curator"} [Term] @@ -231528,6 +336540,9 @@ xref: XAO:0000162 is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: capable_of_part_of GO:0055074 ! calcium ion homeostasis +relationship: contains_process GO:0006590 ! thyroid hormone generation +relationship: only_in_taxon NCBITaxon:7711 ! Chordata relationship: transformation_of UBERON:0007689 ! thyroid diverticulum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg xsd:anyURI @@ -231558,9 +336573,9 @@ xref: DHBA:12471 xref: DHBA:12475 xref: FMA:68875 xref: HBA:9159 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=589 {source="BIRNLEX:1110"} xref: MA:0001022 xref: MBA:238 +xref: neuronames:589 {source="BIRNLEX:1110"} xref: UMLS:C0175423 {source="BIRNLEX:1110"} xref: Wikipedia:Pontine_raphe_nucleus is_a: UBERON:0006331 ! brainstem nucleus @@ -231579,6 +336594,7 @@ namespace: uberon def: "Respiration organ that develops as an outpocketing of the esophagus." [http://orcid.org/0000-0002-6601-2165] comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -231617,8 +336633,9 @@ relationship: develops_from UBERON:0000118 ! lung bud relationship: in_lateral_side_of UBERON:0000170 ! pair of lungs relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of UBERON:0000170 {note="some species only have a single lung"} ! pair of lungs -property_value: RO:0002161 NCBITaxon:32443 {editor="BGEE:fb", source="https://github.com/obophenotype/uberon/issues/701"} -property_value: RO:0002161 NCBITaxon:7777 {editor="BGEE:fb", source="https://github.com/obophenotype/uberon/issues/701"} +property_value: RO:0002161 NCBITaxon:32443 {editor="https://orcid.org/0000-0002-9415-5104", source="https://github.com/obophenotype/uberon/issues/701"} +property_value: RO:0002161 NCBITaxon:7777 {editor="https://orcid.org/0000-0002-9415-5104", source="https://github.com/obophenotype/uberon/issues/701"} +property_value: RO:0002175 NCBITaxon:9606 property_value: seeAlso https://github.com/obophenotype/uberon/issues/701 xsd:anyURI property_value: UBPROP:0000001 "Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010567", ontology="AAO", source="AAO:SBH"} property_value: UBPROP:0000003 "Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000310", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.210, DOI:10.1371/journal.pone.0024019 Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D, Gong Z, Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One (2011)", source="http://bgee.unil.ch/"} @@ -231630,6 +336647,7 @@ id: UBERON:0002049 name: vasculature namespace: uberon def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [ZFA:0005249] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -231645,6 +336663,7 @@ relationship: has_part UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0007798 ! vascular system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg xsd:anyURI property_value: editor_note "see also: vascular system. Consider merging?" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "vascular" xsd:string [Term] @@ -231693,6 +336712,7 @@ id: UBERON:0002051 name: epithelium of bronchiole namespace: uberon def: "An epithelium that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "bronchiolar epithelium" EXACT [BTO:0001866] synonym: "bronchiole epithelial tissue" EXACT [OBOL:automatic] @@ -231713,7 +336733,12 @@ xref: UMLS:C1181296 {source="ncithesaurus:Bronchiole_Epithelium"} is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus is_a: UBERON:0003350 ! epithelium of mucosa +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002186 ! bronchiole +relationship: contributes_to_morphology_of UBERON:0002186 ! bronchiole +relationship: has_part CL:0002145 {source="FMA"} ! ciliated columnar cell of tracheobronchial tree relationship: part_of UBERON:0005039 ! mucosa of bronchiole +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "in FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however there are two distinct terms for the corresponding epithelium." xsd:string {external_ontology="FMA"} [Term] @@ -231731,6 +336756,11 @@ xref: UMLS:C1181304 {source="ncithesaurus:Adrenal_Gland_Capsule"} is_a: UBERON:0003893 ! capsule is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0002369 ! adrenal gland +relationship: bounding_layer_of UBERON:0002369 ! adrenal gland +relationship: composed_primarily_of UBERON:0011822 ! dense irregular connective tissue +relationship: contributes_to_morphology_of UBERON:0001235 ! adrenal cortex [Term] id: UBERON:0002053 @@ -231797,6 +336827,15 @@ xref: Wikipedia:Zona_reticularis is_a: UBERON:0009753 {source="MA"} ! adrenal gland cortex zone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png xsd:anyURI +[Term] +id: UBERON:0002056 +name: inferior suprarenal artery +is_a: UBERON:0004573 ! systemic artery +is_a: UBERON:0005624 ! suprarenal artery +intersection_of: UBERON:0005624 ! suprarenal artery +intersection_of: branching_part_of UBERON:0001184 ! renal artery +relationship: branching_part_of UBERON:0001184 ! renal artery + [Term] id: UBERON:0002057 name: phrenic artery @@ -231868,9 +336907,19 @@ xref: SCTID:279282000 xref: UMLS:C0229063 {source="ncithesaurus:Submandibular_Ganglion"} xref: Wikipedia:Submandibular_ganglion is_a: UBERON:0001808 ! parasympathetic ganglion +intersection_of: UBERON:0000045 ! ganglion +intersection_of: extends_fibers_into UBERON:0001736 ! submandibular gland +relationship: extends_fibers_into UBERON:0001736 ! submandibular gland +relationship: extends_fibers_into UBERON:0003721 ! lingual nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/83/Gray778.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/en/thumb/8/83/Gray778.png/200px-Gray778.png xsd:anyURI +[Term] +id: UBERON:0002060 +name: femoral artery +is_a: UBERON:0004573 ! systemic artery +relationship: branching_part_of UBERON:0001308 ! external iliac artery + [Term] id: UBERON:0002061 name: truncus arteriosus @@ -231918,6 +336967,7 @@ xref: EHDAA:2586 xref: EMAPA:16696 xref: FMA:70302 xref: MA:0000078 +xref: MESH:D054089 xref: TAO:0001317 xref: VHOG:0000932 xref: Wikipedia:Atrioventricular_cushions @@ -231961,6 +337011,7 @@ xref: VHOG:0000177 xref: Wikipedia:Sinus_venosus xref: ZFA:0000154 is_a: UBERON:0004151 ! cardiac chamber +disjoint_from: UBERON:0006615 ! venous sinus relationship: immediate_transformation_of UBERON:0007278 {source="Bgee:AN"} ! presumptive sinus venosus relationship: part_of UBERON:0002350 {source="VHOG"} ! conducting system of heart property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png xsd:anyURI @@ -232049,6 +337100,7 @@ name: umbilical vein namespace: uberon def: "The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted]." [https://github.com/obophenotype/uberon/issues/328, Wikipedia:Umbilical_vein] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "vena umbilicalis" RELATED LATIN [Wikipedia:Umbilical_vein] @@ -232073,6 +337125,7 @@ xref: Wikipedia:Umbilical_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0010260 ! umbilical blood vessel property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002067 @@ -232081,6 +337134,7 @@ namespace: uberon def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [http://en.wikipedia.org/wiki/Dermis, ZFIN:curator] def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -232112,7 +337166,6 @@ xref: VHOG:0000108 xref: Wikipedia:Dermis xref: XAO:0000217 xref: ZFA:0001119 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer @@ -232126,6 +337179,7 @@ relationship: part_of UBERON:0002097 {source="FMA"} ! skin of body relationship: superficial_to UBERON:0002072 ! hypodermis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg xsd:anyURI property_value: editor_note "Consider adding a layer-of-skin grouping class for all skin layers" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001119", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000108", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1"} property_value: UBPROP:0000003 "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000108", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1", source="http://bgee.unil.ch/"} @@ -232145,7 +337199,7 @@ xref: EMAPA:18323 xref: FMA:70343 xref: GAID:1313 xref: MA:0001701 -xref: MESH:A16.254.835 +xref: MESH:D014497 xref: NCIT:C12338 xref: RETIRED_EHDAA2:0002138 xref: SCTID:276858000 @@ -232154,6 +337208,7 @@ xref: VHOG:0000735 xref: Wikipedia:Urachus is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: continuous_with UBERON:0007118 ! umbilicus relationship: develops_from UBERON:0004340 {source="EHDAA2"} ! allantois relationship: part_of UBERON:0001255 {source="EHDAA2"} ! urinary bladder property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png xsd:anyURI @@ -232165,6 +337220,7 @@ id: UBERON:0002069 name: stratum granulosum of epidermis namespace: uberon def: "The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis." [ISBN:0-683-40008-8, MP:0001239] +subset: human_reference_atlas subset: pheno_slim synonym: "epidermis granular layer" RELATED [] synonym: "epidermis stratum granulosum" EXACT [] @@ -232180,7 +337236,12 @@ xref: UMLS:C0221923 {source="ncithesaurus:Stratum_Granulosum"} xref: Wikipedia:Stratum_granulosum is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer +intersection_of: UBERON:0013754 ! integumentary system layer +intersection_of: composed_primarily_of CL:0000712 ! stratum granulosum cell +relationship: BSPO:0015014 UBERON:0002026 ! stratum spinosum of epidermis +relationship: composed_primarily_of CL:0000712 ! stratum granulosum cell relationship: part_of UBERON:0001003 ! skin epidermis +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002071 @@ -232195,10 +337256,10 @@ synonym: "stratum lucidum" BROAD [BTO:0000364] xref: BTO:0000364 xref: EMAPA:35314 xref: FMA:70540 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1777 xref: MA:0000806 xref: NCIT:C33624 xref: NCIT:C33629 +xref: neuronames:1777 xref: SCTID:419156002 xref: UMLS:C0221922 {source="ncithesaurus:Stratum_Lucidum"} xref: UMLS:C1514985 {source="ncithesaurus:Stratum_Conjunctum"} @@ -232213,6 +337274,7 @@ name: hypodermis namespace: uberon def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [http://en.wikipedia.org/wiki/Hypodermis] def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [Wikipedia:Hypodermis] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -232237,7 +337299,6 @@ xref: TAO:0001136 xref: UMLS:C0278403 {source="ncithesaurus:Subcutis"} xref: Wikipedia:Hypodermis xref: ZFA:0001136 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer relationship: composed_primarily_of UBERON:0001013 ! adipose tissue @@ -232246,6 +337307,7 @@ relationship: deep_to UBERON:0002067 ! dermis relationship: part_of UBERON:0002199 {source="ZFA"} ! integument relationship: superficial_to UBERON:0001015 ! musculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001136", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]." xsd:string {source="FMA:70544"} property_value: UBPROP:0000007 "hypodermal" xsd:string @@ -232260,6 +337322,7 @@ namespace: uberon def: "A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]." [Wikipedia:Hair_follicle] comment: Development notes:Formation largely takes place during fetal and perinatal skin development. However, after skin wounding de novo hair follicle formation may also occur in adult mouse and rabbit skin[DOI:10.1016/j.cub.2008.12.005]. subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -232283,9 +337346,11 @@ xref: Wikipedia:Hair_follicle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0036150 ! skin appendage follicle relationship: develops_from UBERON:0005086 ! hair follicle placode +relationship: overlaps UBERON:0001037 ! strand of hair relationship: part_of UBERON:0001003 {source="FMA"} ! skin epidermis relationship: part_of UBERON:0011932 {source="DOI:10.1016/j.cub.2008.12.005"} ! pilosebaceous unit -property_value: depicted:by Hair:follicle-en.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The earliest reliable record of hair is found in a fossil of the Paleocene period, in which the structure of hair cuticles is preserved. Its appearance suggests that the complicated structure of the hair follicle, closely similar to that of present-day mammals, had already appeared at this time.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001268", ontology="VHOG", source="ISBN:978-4431998051 Morioka K, Hair follicle: differentiation under the electron microscope, An atlas (2005) p.3", source="http://bgee.unil.ch/"} [Term] @@ -232362,6 +337427,9 @@ xref: MA:0000157 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000119 ! cell layer +intersection_of: bounding_layer_of UBERON:0002074 ! hair shaft +relationship: bounding_layer_of UBERON:0002074 ! hair shaft relationship: part_of UBERON:0002074 ! hair shaft [Term] @@ -232382,6 +337450,8 @@ xref: SCTID:318832008 is_a: UBERON:0001851 ! cortex is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0001037 ! strand of hair relationship: part_of UBERON:0002074 ! hair shaft [Term] @@ -232389,6 +337459,7 @@ id: UBERON:0002078 name: right cardiac atrium namespace: uberon def: "A cardiac atrium that is in the left side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Right_atrium] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "atrium dextrum" RELATED LATIN [Wikipedia:Right_atrium] @@ -232416,7 +337487,9 @@ is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: in_right_side_of UBERON:0000948 ! heart +relationship: connected_to UBERON:0004537 ! blood vasculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA]" xsd:string {source="FMA:7096"} property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000328", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI @@ -232426,6 +337499,7 @@ id: UBERON:0002079 name: left cardiac atrium namespace: uberon def: "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Left_atrium] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "atrium sinistrum" EXACT LATIN [Wikipedia:Left_atrium] @@ -232453,7 +337527,9 @@ is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: in_left_side_of UBERON:0000948 ! heart +relationship: connected_to UBERON:0004537 ! blood vasculature property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA]" xsd:string {source="FMA:7097"} property_value: UBPROP:0000001 "The chamber of the heart that receives blood from the lungs[XAO:EJS]." xsd:string {source="XAO:EJS"} property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000369", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"} @@ -232464,6 +337540,7 @@ id: UBERON:0002080 name: heart right ventricle namespace: uberon def: "A cardiac ventricle that is in the right side of the heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cardiac right ventricle" EXACT [] @@ -232489,9 +337566,11 @@ is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: in_right_side_of UBERON:0000948 ! heart +relationship: connected_to UBERON:0004537 ! blood vasculature relationship: develops_from UBERON:0009889 {source="PMID:17276708"} ! secondary heart field relationship: has_developmental_contribution_from UBERON:0004706 {source="cjm"} ! bulbus cordis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000717", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI property_value: UBPROP:0000008 "In mammals continuous with the pulmonary arteries" xsd:string @@ -232624,6 +337703,7 @@ id: UBERON:0002084 name: heart left ventricle namespace: uberon def: "A cardiac ventricle that is in the left side of the heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cardiac left ventricle" EXACT [] @@ -232649,9 +337729,11 @@ is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle intersection_of: in_left_side_of UBERON:0000948 ! heart +relationship: connected_to UBERON:0004537 ! blood vasculature relationship: continuous_with UBERON:0000947 ! aorta relationship: develops_from UBERON:0004140 {source="GO"} ! primary heart field property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000718", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000718", ontology="VHOG", source="DOI:10.1126/science.1190181 Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L, Early chordate origins of the vertebrate second heart field. Science (2010)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI @@ -232740,6 +337822,15 @@ property_value: UBPROP:0000009 "In the embryo, the atrioventricular canal delays property_value: UBPROP:0000011 "The right side of the AVC becomes the tricuspid valve whereas the left side of the AVC will become the bicuspid valve" xsd:string property_value: UBPROP:0000012 "this is a lumen in EHDAA2" xsd:string {external_ontology="EHDAA2"} +[Term] +id: UBERON:0002089 +name: thoracodorsal vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001112 ! latissimus dorsi muscle +relationship: drains UBERON:0001112 ! latissimus dorsi muscle +relationship: tributary_of UBERON:0000985 ! axillary vein + [Term] id: UBERON:0002090 name: postcranial axial skeleton @@ -232880,6 +337971,7 @@ name: interventricular septum namespace: uberon def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." [FMA:7133] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "heart interventricular septum" EXACT [MA:0000085] @@ -232912,6 +338004,7 @@ intersection_of: adjacent_to UBERON:0002084 ! heart left ventricle relationship: adjacent_to UBERON:0002080 ! heart right ventricle relationship: adjacent_to UBERON:0002084 ! heart left ventricle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The partition separating the right and left ventricles of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000386", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/interventricular+septum"} property_value: UBPROP:0000003 "The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000386", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.430", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999)" xsd:string {source="ISBN:0124020607"} @@ -232932,12 +338025,13 @@ xref: EV:0100083 xref: FMA:7144 xref: GAID:21 xref: galen:Mesentery -xref: MESH:A01.047.025.600.451 +xref: MESH:D008643 xref: NCIT:C33103 xref: SCTID:362707009 xref: UMLS:C0025474 {source="ncithesaurus:Mesentery"} xref: Wikipedia:Mesentery#Mesentery_.28general.29 is_a: UBERON:0000042 ! serous membrane +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png xsd:anyURI property_value: UBPROP:0000007 "mesenteric" xsd:string property_value: UBPROP:0000012 "in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery." xsd:string {external_ontology="FMA"} @@ -232948,6 +338042,7 @@ name: skin of body namespace: uberon def: "The organ covering the body that consists of the dermis and epidermis." [UBERON:cjm] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim @@ -232983,6 +338078,7 @@ relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embr relationship: part_of UBERON:0002199 ! integument property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg xsd:anyURI property_value: IAO:0000232 "consider 'integumentary system' for invertebrates" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "MA uses the term skin to refer to what is called here: zone of skin" xsd:string {external_ontology="FMA"} [Term] @@ -233129,9 +338225,11 @@ xref: XAO:0003027 is_a: UBERON:0004708 {specialization_within="Sarcopterygians"} ! paired limb/fin intersection_of: UBERON:0000475 ! organism subdivision intersection_of: has_skeleton UBERON:0004381 ! skeleton of limb +relationship: confers_advantage_in ENVO:00000446 ! terrestrial biome relationship: develops_from UBERON:0004347 ! limb bud relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_skeleton UBERON:0004381 ! skeleton of limb +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda property_value: UBPROP:0000001 "Organism subdivision that has as its parts the jointed appendages used for locomotion and manipulation.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010336", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000336", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000336", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268"} @@ -233324,6 +338422,7 @@ name: spleen namespace: uberon def: "The organ that functions to filter blood and to store red corpuscles and platelets." [ISBN:0-683-40008-8, MP:0000689] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -233340,7 +338439,7 @@ xref: GAID:1289 xref: galen:Spleen xref: MA:0000141 xref: MAT:0000085 -xref: MESH:A15.382.520.604.713 +xref: MESH:D013154 xref: MIAA:0000085 xref: NCIT:C12432 xref: OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA @@ -233356,7 +338455,9 @@ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera relationship: develops_from UBERON:0006293 ! spleen primordium -property_value: depicted:by Illu:spleen.jpg xsd:anyURI +relationship: only_in_taxon NCBITaxon:7776 {source="multiple sources - true spleen appear in jawed vertebrates"} ! Gnathostomata +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An organ involved in red blood cell filtration and immune response.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010395", ontology="AAO", source="AAO:BMZ"} property_value: UBPROP:0000003 "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000120", ontology="VHOG", source="ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "lienal" xsd:string @@ -233371,6 +338472,7 @@ name: liver namespace: uberon def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -233406,10 +338508,19 @@ is_a: UBERON:0002365 {source="BTO", source="EHDAA2", source="GO-def"} ! exocrine is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006925 ! digestive system gland +relationship: contributes_to_morphology_of UBERON:0002423 ! hepatobiliary system relationship: develops_from UBERON:0004161 {source="EHDAA2"} ! septum transversum relationship: develops_from UBERON:0008836 {source="http://www.stembook.org/node/512"} ! liver bud +relationship: has_part UBERON:0004647 ! liver lobule +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: overlaps UBERON:0002405 {source="ZFA-weakened"} ! immune system relationship: part_of UBERON:0002423 {source="ZFA"} ! hepatobiliary system -property_value: depicted:by Leber:Schaf.jpg xsd:anyURI +relationship: produces UBERON:0001970 ! bile +relationship: site_of GO:0002384 ! hepatic immune response +relationship: site_of GO:0005978 ! glycogen biosynthetic process +relationship: site_of GO:0005980 ! glycogen catabolic process +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Organ which secretes bile and participates in formation of certain blood proteins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010111", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010111", ontology="AAO"} property_value: UBPROP:0000003 "All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000257", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.526, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} @@ -233425,6 +338536,7 @@ name: small intestine namespace: uberon def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [ISBN:0073040584, Wikipedia:Small_intestine] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -233447,7 +338559,7 @@ xref: GAID:313 xref: galen:SmallIntestine xref: MA:0000337 xref: MAT:0000047 -xref: MESH:A03.492.411.620 +xref: MESH:D007421 xref: MIAA:0000047 xref: NCIT:C12386 xref: OpenCyc:Mx4rvVjlIJwpEbGdrcN5Y29ycA @@ -233460,11 +338572,25 @@ xref: XAO:0000130 xref: ZFA:0001323 is_a: UBERON:0004921 {order="2", source="cjm"} ! subdivision of digestive tract is_a: UBERON:0013765 ! digestive system element +relationship: contributes_to_morphology_of UBERON:0000160 ! intestine +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000160 ! intestine property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001323", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000055", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0002109 +name: pair of nares +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0034925 ! anatomical collection +intersection_of: UBERON:0034925 ! anatomical collection +intersection_of: has_member UBERON:0000003 {cardinality="2"} ! naris +relationship: has_member UBERON:0000003 ! naris +relationship: has_part UBERON:0000003 ! naris +relationship: part_of UBERON:0000004 ! nose + [Term] id: UBERON:0002110 name: gall bladder @@ -233507,11 +338633,12 @@ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013765 ! digestive system element is_a: UBERON:0017672 ! abdominal viscera is_a: UBERON:0018707 {source="BTO"} ! bladder organ +relationship: contributes_to_morphology_of UBERON:0001173 ! biliary tree relationship: develops_from UBERON:0004912 ! biliary bud relationship: develops_from UBERON:0006242 {evidence="definitional"} ! gall bladder primordium relationship: part_of UBERON:0002423 {source="MA", source="ZFA", source="cjm"} ! hepatobiliary system -property_value: depicted:by Abdomal:organs.svg xsd:anyURI property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:10114 {source="ISBN:9780120749034"} property_value: RO:0002161 NCBITaxon:8801 {source="GOC:mr", source="ISBN:9781840761122"} property_value: RO:0002161 NCBITaxon:8930 {source="GOC:mr", source="ISBN:9781840761122"} @@ -233590,6 +338717,7 @@ namespace: uberon def: "A paired organ of the urinary tract which has the production of urine as its primary function." [http://anatomy.uams.edu/anatomyhtml/kidney.html, Wikipedia:Kidney] def: "A paired organ of the urinary tract which has the production of urine as its primary function." [http://anatomy.uams.edu/anatomyhtml/kidney.html, http://en.wikipedia.org/wiki/Kidney] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -233627,8 +338755,10 @@ relationship: contributes_to_morphology_of UBERON:0001008 ! renal system relationship: develops_from UBERON:0003918 {evidence="definitional"} ! kidney mesenchyme relationship: develops_from UBERON:0005095 ! kidney rudiment relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0011143 {source="FMA"} ! upper urinary tract property_value: RO:0002171 UBERON:0000160 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000250", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000007 "renal" xsd:string property_value: UBPROP:0000202 FMA:264815 @@ -233639,6 +338769,7 @@ name: duodenum namespace: uberon def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [ISBN:0815318960, Wikipedia:Duodenum] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -233655,7 +338786,7 @@ xref: GAID:284 xref: galen:Duodenum xref: MA:0000338 xref: MAT:0000044 -xref: MESH:A03.492.411.620.270 +xref: MESH:D004386 xref: MIAA:0000044 xref: NCIT:C12263 xref: OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA @@ -233665,9 +338796,13 @@ xref: VHOG:0000052 xref: Wikipedia:Duodenum xref: XAO:0000236 is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract +relationship: continuous_with UBERON:0001166 ! pylorus +relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine +relationship: proximalmost_part_of UBERON:0002108 ! small intestine property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:7955 {source="ZFA:0000348"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000052", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "duodenal" xsd:string property_value: UBPROP:0000008 "In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum." xsd:string {scope="NCBITaxon:32443", source="Wikipedia:Duodenum"} @@ -233679,6 +338814,7 @@ name: jejunum namespace: uberon def: "The portion of the small intestine that extends from the duodenum to the ileum." [MGI:monikat, MP:0004002] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "intestinum jejunum" RELATED [BTO:0000657] @@ -233694,7 +338830,7 @@ xref: GAID:318 xref: galen:Jejunum xref: MA:0000340 xref: MAT:0000045 -xref: MESH:A03.492.411.620.625 +xref: MESH:D007583 xref: MIAA:0000045 xref: NCIT:C12388 xref: OpenCyc:Mx4rwATkPJwpEbGdrcN5Y29ycA @@ -233703,10 +338839,12 @@ xref: UMLS:C0022378 {source="ncithesaurus:Jejunum"} xref: VHOG:0000053 xref: Wikipedia:Jejunum is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract +relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut relationship: part_of UBERON:0002108 ! small intestine property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg xsd:anyURI property_value: editor_note "TODO consider ZFA:0001323 mid intestine, see also small intestine" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The first two fifth of the small intestine beyond the duodenum. It extends from the end of the duodenum to the ileum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000053", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "jejunal" xsd:string property_value: UBPROP:0000008 "The jejunum is the middle section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms middle intestine or mid-gut may be used instead of jejunum.[Wikipedia:Jejunum]" xsd:string @@ -233717,6 +338855,7 @@ name: ileum namespace: uberon def: "The portion of the small intestine that extends from the jejunum to the colon." [ISBN:0-683-40008-8, MGI:csmith, MP:0002581] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "distal intestine" RELATED [BTO:0000620] @@ -233734,7 +338873,7 @@ xref: GAID:315 xref: galen:Ileum xref: MA:0000339 xref: MAT:0000282 -xref: MESH:A03.492.411.620.484 +xref: MESH:D007082 xref: MIAA:0000282 xref: NCIT:C12387 xref: OpenCyc:Mx4rvdcLHZwpEbGdrcN5Y29ycA @@ -233744,9 +338883,11 @@ xref: VHOG:0000647 xref: Wikipedia:Ileum xref: XAO:0000237 is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract +relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg xsd:anyURI property_value: editor_note "TODO consider ZFA:0000706 posterior intestine, see also colon" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000647", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "ileal" xsd:string property_value: UBPROP:0000008 "The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may be used instead of ileum.[Wikipedia:Ileum]" xsd:string @@ -233814,6 +338955,7 @@ xref: http://en.wikipedia.org/wiki/Pronephros xref: http://linkedlifedata.com/resource/umls/id/C0231048 xref: http://www.snomedbrowser.com/Codes/Details/308804007 xref: MAT:0000117 +xref: MESH:D060910 xref: MIAA:0000117 xref: NCIT:C34280 xref: SCTID:308804007 @@ -233842,6 +338984,7 @@ id: UBERON:0002122 name: capsule of thymus namespace: uberon def: "The fibrous connective tissue surrounding the thymus." [MP:0002368] +subset: human_reference_atlas subset: pheno_slim synonym: "thymic capsule" EXACT [] synonym: "thymus capsule" EXACT [] @@ -233853,12 +338996,17 @@ xref: SCTID:188181003 xref: UMLS:C0229945 {source="ncithesaurus:Thymic_Capsule"} is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003893 ! capsule +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0002370 ! thymus +relationship: bounding_layer_of UBERON:0002370 ! thymus +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002123 name: cortex of thymus namespace: uberon def: "The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes." [ISBN:0-683-40008-8, MP:0002371] +subset: human_reference_atlas subset: pheno_slim synonym: "thymic cortex" EXACT [BTO:0002934] synonym: "thymus cortex" EXACT [MA:0000767] @@ -233872,8 +339020,14 @@ xref: UMLS:C0229948 {source="ncithesaurus:Thymus_Cortex"} xref: Wikipedia:Thymus#Cortex is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001851 ! cortex +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0002370 ! thymus +relationship: capable_of_part_of GO:0045058 ! T cell selection +relationship: has_part CL:0000542 ! lymphocyte +relationship: has_part CL:0002293 ! epithelial cell of thymus relationship: part_of UBERON:0002370 ! thymus property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin[WP]" xsd:string [Term] @@ -233882,6 +339036,7 @@ name: medulla of thymus namespace: uberon def: "Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size." [Wikipedia:Thymus#Medulla] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim synonym: "medulla of thymus gland" EXACT [OBOL:automatic] synonym: "thymus gland medulla" EXACT [OBOL:automatic] @@ -233897,14 +339052,18 @@ xref: UMLS:C0229949 {source="ncithesaurus:Thymus_Medulla"} xref: Wikipedia:Thymus#Medulla is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000958 ! medulla of organ +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002125 name: thymus lobule namespace: uberon def: "A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]." [http://orcid.org/0000-0002-6601-2165, ncithesaurus:Thymic_Lobule] +subset: human_reference_atlas subset: pheno_slim synonym: "lobule of thymus" EXACT [FMA:72215] synonym: "thymic lobule" EXACT [] @@ -233916,7 +339075,14 @@ xref: SCTID:187882006 xref: UMLS:C1522462 {source="ncithesaurus:Thymic_Lobule"} is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0009911 ! lobule +intersection_of: UBERON:0009911 ! lobule +intersection_of: part_of UBERON:0002370 ! thymus +relationship: contributes_to_morphology_of UBERON:0002370 ! thymus +relationship: has_part CL:0000235 ! macrophage +relationship: has_part CL:0000432 ! reticular cell +relationship: has_part CL:0000542 ! lymphocyte relationship: part_of UBERON:0005483 ! thymus lobe +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in the mouse, the lobes of the thymus are not subdivided into lobules but only in the central medulla and a peripheral cortex (i.e. there is no distinct sublobulation). In humans, the two thymus lobes are composed of many lobules of various sizes which contain follicles, each comprising a medulla and a cortex. in the rat, the thymus is partially subdivided into lobules separated by thin bands of connective tissue which are continuous with the thin connective tissue capsule.[MP]" xsd:string property_value: UBPROP:0000010 "Lymphocytes, reticular cells and macrophages are found in the lobules" xsd:string @@ -233952,9 +339118,9 @@ xref: EMAPA:19241 xref: EV:0100277 xref: FMA:72243 xref: HBA:9560 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=748 {source="BIRNLEX:1164"} xref: MA:0001040 xref: MBA:83 +xref: neuronames:748 {source="BIRNLEX:1164"} xref: TAO:0000215 xref: UMLS:C0228540 {source="BIRNLEX:1164"} xref: VHOG:0001627 @@ -233994,9 +339160,10 @@ xref: EMAPA:35840 xref: EV:0100263 xref: FMA:72247 xref: HBA:9177 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=569 {source="BIRNLEX:1307"} xref: MA:0001026 xref: MBA:398 +xref: MESH:D065832 +xref: neuronames:569 {source="BIRNLEX:1307"} xref: UMLS:C0175427 {source="BIRNLEX:1307"} xref: VHOG:0001381 xref: Wikipedia:Superior_olivary_complex @@ -234017,6 +339184,7 @@ name: cerebellar cortex namespace: uberon def: "The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer." [BIRNLEX:1566] comment: The circuits in the cerebellar cortex look similar across all classes of vertebrates, including fish, reptiles, birds, and mammals (e.g., Fig. 2). This has been taken as evidence that the cerebellum performs functions important to all vertebrate species. (Wikipedia) +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cortex cerebellaris" RELATED [BTO:0000043] @@ -234036,11 +339204,11 @@ xref: EV:0100294 xref: FMA:72248 xref: GAID:596 xref: HBA:4697 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=647 {source="BIRNLEX:1566"} xref: MA:0000199 xref: MBA:528 xref: MESH:D002525 xref: NCIT:C49216 +xref: neuronames:647 {source="BIRNLEX:1566"} xref: SCTID:361593004 xref: UMLS:C0007759 {source="ncithesaurus:Cerebellar_Cortex"} xref: UMLS:C0007759 {source="BIRNLEX:1566"} @@ -234048,9 +339216,11 @@ xref: UMLS:C1284087 {source="BIRNLEX:1566"} xref: VHOG:0001597 xref: Wikipedia:Cerebellar_cortex is_a: UBERON:0019263 ! gray matter of hindbrain +relationship: contributes_to_morphology_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum -property_value: depicted:by Cerebellum:NIH.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png xsd:anyURI property_value: RO:0002171 UBERON:0002130 {source="ABA"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function[GO][GO:0021695]." xsd:string {source="GO:0021695"} [Term] @@ -234081,9 +339251,9 @@ xref: EV:0100299 xref: FMA:72249 xref: GAID:599 xref: HBA:4780 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=682 {source="BIRNLEX:1568"} xref: MBA:519 xref: MESH:D002529 +xref: neuronames:682 {source="BIRNLEX:1568"} xref: UMLS:C0007763 {source="BIRNLEX:1568"} xref: Wikipedia:Deep_cerebellar_nuclei is_a: UBERON:0007245 ! nuclear complex of neuraxis @@ -234115,8 +339285,8 @@ xref: DHBA:12838 xref: EMAPA:35215 xref: EV:0100295 xref: FMA:72251 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=650 xref: MA:0000991 +xref: neuronames:650 xref: SCTID:279359004 xref: VHOG:0001598 xref: Wikipedia:Anterior_lobe_of_cerebellum @@ -234151,9 +339321,9 @@ xref: BTO:0003836 xref: EV:0100300 xref: FMA:72260 xref: HBA:12946 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=683 {source="BIRNLEX:1171"} xref: MA:0001008 xref: MBA:846 +xref: neuronames:683 {source="BIRNLEX:1171"} xref: SCTID:279221005 xref: UMLS:C0086120 {source="BIRNLEX:1171"} xref: VHOG:0001700 @@ -234184,7 +339354,12 @@ xref: TAO:0005064 xref: VHOG:0001472 xref: Wikipedia:Heart_valve#Atrioventricular_valves xref: ZFA:0005064 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000946 ! cardial valve +relationship: attaches_to UBERON:0004292 ! cardiac skeleton +relationship: connects UBERON:0002081 ! cardiac atrium +relationship: connects UBERON:0002082 ! cardiac ventricle +relationship: has_part UBERON:0005994 ! chorda tendineae relationship: part_of UBERON:0011820 {source="EHDAA2"} ! atrioventricular region property_value: UBPROP:0000001 "The atrioventricular valve has four distinct leaflets oriented anterior, posterior, left, and right of the atrioventricular orifice. Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005064", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Valve in the heart through which blood flows from the atria to the ventricles. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001472", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/atrioventricular+valve"} @@ -234196,6 +339371,7 @@ id: UBERON:0002134 name: tricuspid valve namespace: uberon def: "An atrioventricular valve that is part of the outflow part of the right atrium." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "right atrioventricular valve" EXACT [FMA:7234] @@ -234218,8 +339394,13 @@ xref: VHOG:0000816 xref: Wikipedia:Tricuspid_valve is_a: UBERON:0002133 ! atrioventricular valve is_a: UBERON:0005208 ! right atrium valve +intersection_of: UBERON:0002133 ! atrioventricular valve +intersection_of: part_of UBERON:0005965 ! outflow part of right atrium +relationship: connects UBERON:0002078 ! right cardiac atrium +relationship: connects UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0005965 ! outflow part of right atrium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The three-segmented valve of the heart that keeps blood in the right ventricle from flowing back into the right atrium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000816", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Tricuspid+valves"} property_value: UBPROP:0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000816", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA part_ofs changed to connects" xsd:string {external_ontology="FMA"} @@ -234230,6 +339411,7 @@ name: mitral valve namespace: uberon def: "An atrioventricular valve that is part of the outflow part of the left atrium." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bicuspid valve" RELATED [] @@ -234251,8 +339433,14 @@ xref: UMLS:C0026264 {source="ncithesaurus:Mitral_Valve"} xref: VHOG:0000817 xref: Wikipedia:Mitral_valve is_a: UBERON:0002133 ! atrioventricular valve +intersection_of: UBERON:0002133 ! atrioventricular valve +intersection_of: part_of UBERON:0005966 ! outflow part of left atrium +relationship: attaches_to UBERON:0005995 ! mitral valve anulus +relationship: connects UBERON:0002079 ! left cardiac atrium +relationship: connects UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0005966 ! outflow part of left atrium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A valve of the heart, composed of two triangular flaps, that is located between the left atrium and left ventricle and regulates blood flow between these chambers. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000817", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mitral+valve"} property_value: UBPROP:0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000817", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA part_ofs changed to connects" xsd:string {external_ontology="FMA"} @@ -234264,6 +339452,7 @@ namespace: uberon def: "Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA]." [FMA:FMA, Wikipedia:Aortic_valve] comment: Human variation: It is normally tricuspid (with three leaflets), although in 1% of the population it is found to be congenitally bicuspid (two leaflets) subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "valva aortae" RELATED LATIN [Wikipedia:Aortic_valve] @@ -234286,6 +339475,7 @@ xref: Wikipedia:Aortic_valve is_a: UBERON:0005623 {source="MA"} ! semi-lunar valve relationship: part_of UBERON:0005956 ! outflow part of left ventricle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The valve between the left ventricle of the heart and the ascending aorta, consisting of three semilunar cusps. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000815", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aortic+valve"} [Term] @@ -234312,9 +339502,9 @@ xref: EMAPA:35828 xref: FMA:72414 xref: GAID:794 xref: HBA:9489 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=483 {source="BIRNLEX:1028"} xref: MA:0002941 -xref: MESH:A08.713.810 +xref: MESH:D013351 +xref: neuronames:483 {source="BIRNLEX:1028"} xref: SCTID:369193006 xref: TAO:0000683 xref: UMLS:C0038533 {source="BIRNLEX:1028"} @@ -234331,6 +339521,7 @@ id: UBERON:0002146 name: pulmonary valve namespace: uberon def: "The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery." [Wikipedia:Pulmonary_valve] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "pulmonic valve" EXACT [] @@ -234350,7 +339541,13 @@ xref: UMLS:C0034086 {source="ncithesaurus:Pulmonary_Valve"} xref: VHOG:0000814 xref: Wikipedia:Pulmonary_valve is_a: UBERON:0005623 ! semi-lunar valve +intersection_of: UBERON:0005623 ! semi-lunar valve +intersection_of: connects UBERON:0002012 ! pulmonary artery +intersection_of: connects UBERON:0002082 ! cardiac ventricle +relationship: connects UBERON:0002012 ! pulmonary artery +relationship: connects UBERON:0002082 ! cardiac ventricle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The valve with semilunar cusps at the entrance to the pulmonary trunk from the right ventricle of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000814", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+valve"} [Term] @@ -234370,6 +339567,7 @@ synonym: "locus cinereus" RELATED [BTO:0001408] synonym: "locus coeruleu" EXACT [] synonym: "locus coeruleus" EXACT [] synonym: "locus coeruleus (Vicq d'Azyr)" RELATED [NeuroNames:583] +synonym: "Noradrenergic cell group A6" EXACT [Noradrenergic_cell_group_A6&oldid=981960774] synonym: "nucleus caeruleus" EXACT LATIN [FMA:72478, FMA:TA] synonym: "nucleus loci caerulei" RELATED LATIN [NeuroNames:583] synonym: "nucleus of locus caeruleus" EXACT [] @@ -234387,11 +339585,11 @@ xref: EMAPA:35502 xref: FMA:72478 xref: GAID:577 xref: HBA:9148 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=583 {source="BIRNLEX:905"} xref: MA:0001017 xref: MBA:147 xref: MESH:D008125 xref: NCIT:C97333 +xref: neuronames:583 {source="BIRNLEX:905"} xref: SCTID:369016004 xref: TAO:0000539 xref: UMLS:C0023951 {source="BIRNLEX:905"} @@ -234400,6 +339598,8 @@ xref: Wikipedia:Locus_ceruleus xref: ZFA:0000539 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:8440015 ! noradrenergic cell groups relationship: capable_of GO:0048243 ! norepinephrine secretion relationship: part_of UBERON:0003023 {notes="check ZFA", source="NIFSTD"} ! pontine tegmentum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png xsd:anyURI @@ -234428,9 +339628,9 @@ xref: EHDAA2:0004646 xref: EMAPA:37756 {source="MA:th"} xref: FMA:72482 xref: HBA:9194 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=590 {source="BIRNLEX:1131"} xref: MA:0001027 xref: MBA:462 +xref: neuronames:590 {source="BIRNLEX:1131"} xref: SCTID:369028007 xref: UMLS:C0175447 {source="BIRNLEX:1131"} xref: Wikipedia:Superior_salivatory_nucleus @@ -234455,6 +339655,7 @@ id: UBERON:0002150 name: superior cerebellar peduncle namespace: uberon def: "A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)." [BIRNLEX:1711] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brachium conjunctivum" EXACT [BIRNLEX:1711] @@ -234477,15 +339678,16 @@ xref: BM:BC xref: DHBA:12354 xref: DMBA:17793 xref: HBA:9297 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1736 {source="BIRNLEX:1711"} xref: MA:0002746 xref: MBA:326 +xref: neuronames:1736 {source="BIRNLEX:1711"} xref: SCTID:279218008 xref: UMLS:C0152391 {source="BIRNLEX:1711"} xref: Wikipedia:Superior_cerebellar_peduncle is_a: UBERON:0007416 ! cerebellar peduncle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray704.png xsd:anyURI property_value: editor_note "we follow NIF in dividing this into 3 parts. This allows for consistency with ABA" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "we make the TAO class disjoint for now as it's not clear if this is the analagous structure" xsd:string {external_ontology="TAO"} [Term] @@ -234493,6 +339695,7 @@ id: UBERON:0002152 name: middle cerebellar peduncle namespace: uberon def: "Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM)." [BIRNLEX:1529] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "brachium pontis" EXACT [BIRNLEX:1529] @@ -234511,9 +339714,10 @@ xref: BM:Pons-BP xref: DHBA:12768 xref: FMA:72515 xref: HBA:9294 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=620 {source="BIRNLEX:1529"} xref: MA:0002745 xref: MBA:78 +xref: MESH:D065837 +xref: neuronames:620 {source="BIRNLEX:1529"} xref: NIFSTD_RETIRED:birnlex_1699 xref: SCTID:279219000 xref: UMLS:C0152392 {source="BIRNLEX:1529"} @@ -234522,6 +339726,7 @@ is_a: UBERON:0007416 ! cerebellar peduncle is_a: UBERON:0019292 ! white matter of pons relationship: part_of UBERON:0002567 {source="FMA"} ! basal part of pons property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray705.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002153 @@ -234553,9 +339758,9 @@ xref: DHBA:12402 xref: DMBA:16823 xref: FMA:72537 xref: HBA:12948 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=690 {source="BIRNLEX:1146"} xref: MA:0001009 xref: MBA:989 +xref: neuronames:690 {source="BIRNLEX:1146"} xref: SCTID:279224002 xref: UMLS:C0175490 {source="BIRNLEX:1146"} xref: VHOG:0001699 @@ -234583,10 +339788,10 @@ xref: EMAPA:35143 xref: FMA:72607 xref: GAID:591 xref: HBA:9522 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=772 {source="BIRNLEX:2636"} xref: MA:0001034 xref: MBA:207 xref: MESH:D031608 +xref: neuronames:772 {source="BIRNLEX:2636"} xref: SCTID:369039005 xref: TAO:0005146 xref: UMLS:C0228530 {source="BIRNLEX:2636"} @@ -234613,6 +339818,7 @@ id: UBERON:0002163 name: inferior cerebellar peduncle namespace: uberon def: "Regional part of medullary white matter (according to Neuronames) primarily found at the level of the open medulla, consisting of a large bundle of fibers projecting to and projecting from the cerebellum. The icp is continuous with the dorsal spinocerebellar tract and also contains a large number of fibers originating in the inferior olivary complex (MM)." [BIRNLEX:1691] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corpus restiforme" EXACT LATIN [FMA:72615, FMA:TA] @@ -234631,9 +339837,9 @@ xref: DHBA:12741 xref: DMBA:17772 xref: FMA:72615 xref: HBA:9291 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=781 {source="BIRNLEX:1691"} xref: MA:0002744 xref: MBA:1123 +xref: neuronames:781 {source="BIRNLEX:1691"} xref: NIFSTD_RETIRED:birnlex_1645 xref: SCTID:362418008 xref: UMLS:C0152393 {source="BIRNLEX:1691"} @@ -234641,6 +339847,7 @@ xref: Wikipedia:Inferior_cerebellar_peduncle is_a: UBERON:0007416 ! cerebellar peduncle is_a: UBERON:0014649 ! white matter of medulla oblongata property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fc/Gray677.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002165 @@ -234800,6 +340007,9 @@ xref: Wikipedia:Alveolar_sac is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000117 ! respiratory tube is_a: UBERON:0007499 ! epithelial sac +intersection_of: UBERON:0007499 ! epithelial sac +intersection_of: part_of UBERON:0008874 ! pulmonary acinus +relationship: contributes_to_morphology_of UBERON:0008874 ! pulmonary acinus relationship: part_of UBERON:0006524 {source="MA"} ! alveolar system relationship: part_of UBERON:0008874 {source="FMA"} ! pulmonary acinus @@ -234864,6 +340074,7 @@ id: UBERON:0002173 name: pulmonary alveolar duct namespace: uberon def: "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli." [ISBN:0-683-40008-8, MGI:cwg, MP:0002271] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "alveolar duct" EXACT [MA:0000417] @@ -234879,6 +340090,7 @@ xref: Wikipedia:Alveolar_duct is_a: UBERON:0000117 ! respiratory tube relationship: part_of UBERON:0006524 ! alveolar system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8f/Gray975.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "In human anatomy, respiratory bronchioles exists proximal to the alveolar ducts. The epithelial lining consists of smooth muscle knobs covered by nonciliated, simple cuboidal cells. The smooth muscle constricts under parasympathetic innervation and relax under sympathetic innervation" xsd:string [Term] @@ -234931,6 +340143,9 @@ xref: SCTID:361955002 xref: UMLS:C0225608 {source="ncithesaurus:Right_Main_Bronchus"} xref: Wikipedia:Right_main_bronchus is_a: UBERON:0002182 ! main bronchus +intersection_of: UBERON:0002182 ! main bronchus +intersection_of: continuous_with UBERON:0006518 ! right lung lobe +relationship: continuous_with UBERON:0006518 ! right lung lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI property_value: UBPROP:0000008 "Divides into 3 lobar bronchi in humans" xsd:string {source="ISBN:0123813611"} @@ -234955,6 +340170,9 @@ xref: SCTID:361959008 xref: UMLS:C0225630 {source="ncithesaurus:Left_Main_Bronchus"} xref: Wikipedia:Left_main_bronchus is_a: UBERON:0002182 ! main bronchus +intersection_of: UBERON:0002182 ! main bronchus +intersection_of: continuous_with UBERON:0008951 ! left lung lobe +relationship: continuous_with UBERON:0008951 ! left lung lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI property_value: UBPROP:0000008 "Divides into 2 lobar bronchi in humans" xsd:string {source="ISBN:0123813611"} @@ -234972,7 +340190,7 @@ synonym: "lateral funiculus" EXACT [ZFA:0000533] synonym: "lateral funiculus of spinal cord" EXACT [] synonym: "lateral white column of spinal cord" EXACT [FMA:74000] xref: FMA:74000 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1673 +xref: neuronames:1673 xref: SCTID:362434006 xref: TAO:0000533 xref: Wikipedia:Lateral_funiculus @@ -234996,13 +340214,14 @@ synonym: "ventral funiculus" EXACT [ZFA:0000605] synonym: "ventral funiculus of spinal cord" EXACT [] synonym: "ventral white column of spinal cord" EXACT [FMA:74003] xref: FMA:74003 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1304 +xref: neuronames:1304 xref: NLX:379 xref: SCTID:362429007 xref: TAO:0000605 xref: Wikipedia:Ventral_funiculus xref: ZFA:0000605 is_a: UBERON:0006127 ! funiculus of spinal cord +relationship: in_lateral_side_of UBERON:0002318 ! white matter of spinal cord property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg xsd:anyURI [Term] @@ -235011,6 +340230,7 @@ name: main bronchus namespace: uberon def: "One of two branches of the trachea." [Wikipedia:Main_bronchus] subset: efo_slim +subset: human_reference_atlas subset: organ_slim subset: uberon_slim synonym: "bronchus principalis" EXACT [FMA:7405] @@ -235033,8 +340253,25 @@ xref: VHOG:0000370 xref: Wikipedia:Main_bronchus is_a: UBERON:0002185 ! bronchus relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium +relationship: distally_connected_to UBERON:0002183 ! lobar bronchus +relationship: proximally_connected_to UBERON:0003126 ! trachea +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "In humans, histologically identical to trachea." xsd:string +[Term] +id: UBERON:0002183 +name: lobar bronchus +is_a: UBERON:0035767 ! intrapulmonary bronchus +relationship: distally_connected_to UBERON:0002184 ! segmental bronchus +relationship: part_of UBERON:0000101 ! lobe of lung + +[Term] +id: UBERON:0002184 +name: segmental bronchus +is_a: UBERON:0035767 ! intrapulmonary bronchus +relationship: part_of UBERON:0000101 ! lobe of lung +relationship: proximally_connected_to UBERON:0002183 ! lobar bronchus + [Term] id: UBERON:0002185 name: bronchus @@ -235065,6 +340302,7 @@ xref: VHOG:0000262 xref: Wikipedia:Bronchus xref: XAO:0000121 is_a: UBERON:0000117 ! respiratory tube +relationship: located_in UBERON:0002224 ! thoracic cavity relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg xsd:anyURI property_value: RO:0002161 NCBITaxon:8507 {source="Wikipedia"} @@ -235091,6 +340329,7 @@ xref: EHDAA:8221 xref: EMAPA:32697 xref: FMA:7410 xref: MA:0000422 +xref: MESH:D055745 xref: NCIT:C12684 xref: OpenCyc:Mx4rvl9iDpwpEbGdrcN5Y29ycA xref: SCTID:278982001 @@ -235098,9 +340337,10 @@ xref: UMLS:C0006270 {source="ncithesaurus:Bronchiole"} xref: VHOG:0000675 xref: Wikipedia:Bronchiole is_a: UBERON:0000117 ! respiratory tube +relationship: branching_part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0007196 {source="FMA"} ! tracheobronchial tree relationship: part_of UBERON:0010368 {source="ncit"} ! pulmonary lobule -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI property_value: UBPROP:0000007 "bronchiolar" xsd:string property_value: UBPROP:0000010 "lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer" xsd:string {source="ISBN:0123813611"} @@ -235109,6 +340349,7 @@ id: UBERON:0002187 name: terminal bronchiole namespace: uberon def: "The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bronchioli terminalis" RELATED LATIN [Wikipedia:Terminal_bronchiole] @@ -235124,13 +340365,15 @@ xref: SCTID:278981008 xref: UMLS:C0225666 {source="ncithesaurus:Terminal_Bronchiole"} xref: Wikipedia:Terminal_bronchiole is_a: UBERON:0002186 ! bronchiole -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002188 name: respiratory bronchiole namespace: uberon def: "A bronchiole that is the first segment of the respiratory zone." [ISBN:0123813611, Wikipedia:Respiratory_bronchiole] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "bronchiolus respiratorii" EXACT LATIN [Wikipedia:Respiratory_bronchiole] @@ -235145,8 +340388,12 @@ xref: SCTID:128517006 xref: UMLS:C1261270 {source="ncithesaurus:Respiratory_Bronchiole"} xref: Wikipedia:Respiratory_bronchiole is_a: UBERON:0002186 ! bronchiole +relationship: contributes_to_morphology_of UBERON:0008874 ! pulmonary acinus +relationship: distally_connected_to UBERON:0002173 ! pulmonary alveolar duct relationship: part_of UBERON:0008874 {source="ISBN:0123813611"} ! pulmonary acinus -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +relationship: proximally_connected_to UBERON:0002187 ! terminal bronchiole +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "mice have few or none of these structures, with the terminal bronchioles transitioning directly to the alveolary ducts" xsd:string {source="ISBN:0123813611"} [Term] @@ -235155,6 +340402,7 @@ name: subcutaneous adipose tissue namespace: uberon alt_id: UBERON:0008875 def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim synonym: "fatty layer of subcutaneous tissue" EXACT [FMA:74315] synonym: "fatty layer of superficial fascia" RELATED [FMA:74315] @@ -235174,6 +340422,7 @@ intersection_of: UBERON:0001013 ! adipose tissue intersection_of: part_of UBERON:0002072 ! hypodermis relationship: contributes_to_morphology_of UBERON:0002072 ! hypodermis relationship: part_of UBERON:0002072 ! hypodermis +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156]" xsd:string {source="MP:0011156"} [Term] @@ -235198,10 +340447,10 @@ xref: DMBA:16163 xref: EMAPA:35832 xref: FMA:74414 xref: HBA:12896 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=188 xref: MA:0000960 xref: MBA:502 xref: NCIT:C33648 +xref: neuronames:188 xref: PBA:10054 xref: PBA:128012354 xref: SCTID:369097009 @@ -235210,7 +340459,7 @@ xref: Wikipedia:Subiculum is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002421 {source="NIFSTD"} ! hippocampal formation -property_value: depicted:by Hippocampus:(brain).jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/99/Hippocampus.gif xsd:anyURI property_value: RO:0002171 UBERON:0001953 {source="ABA"} property_value: RO:0002171 UBERON:0002728 {source="ABA"} property_value: RO:0002171 UBERON:0004683 {source="ABA"} @@ -235235,14 +340484,27 @@ xref: MA:0000013 is_a: UBERON:0000467 {source="MA"} ! anatomical system relationship: only_in_taxon NCBITaxon:33213 ! Bilateria +[Term] +id: UBERON:0002194 +name: capsule of lymph node +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0003893 ! capsule +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0000029 ! lymph node +relationship: bounding_layer_of UBERON:0000029 ! lymph node +relationship: composed_primarily_of UBERON:0002384 ! connective tissue + [Term] id: UBERON:0002195 name: trabecula of lymph node namespace: uberon def: "Membranous process coming from capsule of lymph node[WP]." [Wikipedia:Lymph_node_trabeculae] +subset: human_reference_atlas subset: pheno_slim synonym: "lymph node trabecula" EXACT [] +synonym: "lymph node trabeculae" EXACT PLURAL [] synonym: "lymph node trabeculum" EXACT [] +synonym: "trabeculae of lymph node" EXACT PLURAL [] xref: FMA:74605 xref: MA:0000746 xref: NCIT:C33035 @@ -235250,8 +340512,11 @@ xref: UMLS:C1184179 {source="ncithesaurus:Lymph_Node_Trabecula"} xref: Wikipedia:Lymph_node_trabeculae is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000440 ! trabecula +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002196 @@ -235291,10 +340556,10 @@ xref: EFO:0000230 xref: EHDAA2:0000109 xref: EMAPA:17514 xref: FMA:74627 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=407 {source="BIRNLEX:1581"} xref: MA:0000177 -xref: MESH:A06.407.747.608 +xref: MESH:D010903 xref: NCIT:C12772 +xref: neuronames:407 {source="BIRNLEX:1581"} xref: SCTID:245532007 xref: TAO:0001282 xref: UMLS:C0032008 {source="BIRNLEX:1581"} @@ -235305,7 +340570,12 @@ xref: Wikipedia:Adenohypophysis xref: ZFA:0001282 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0000007 ! pituitary gland relationship: develops_from UBERON:0009122 {source="NCBIBook:NBK53175", source="ZFA"} ! adenohypophyseal placode +relationship: has_part CL:0000438 ! luteinizing hormone secreting cell +relationship: has_part CL:0002312 ! somatotroph +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000007 ! pituitary gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray1181.png xsd:anyURI property_value: UBPROP:0000001 "Region of the pituitary gland derived from the buccal protrusion consisting of three regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010540", ontology="AAO", source="AAO:BJB"} @@ -235345,10 +340615,10 @@ xref: EMAPA:17521 xref: FMA:74634 xref: GAID:463 xref: HBA:12916 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=402 {source="BIRNLEX:925"} xref: MA:0000859 xref: MBA:10671 -xref: MESH:A06.407.747.734.500 +xref: MESH:D008473 +xref: neuronames:402 {source="BIRNLEX:925"} xref: SCTID:369121004 xref: UMLS:C0025056 {source="BIRNLEX:925"} xref: VHOG:0001179 @@ -235402,10 +340672,10 @@ xref: EHDAA2:0001271 xref: EHDAA:7536 xref: EMAPA:17519 xref: FMA:74628 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=401 {source="BIRNLEX:1586"} xref: MA:0000178 -xref: MESH:A06.407.747.734 +xref: MESH:D010904 xref: NCIT:C12773 +xref: neuronames:401 {source="BIRNLEX:1586"} xref: SCTID:245527006 xref: TAO:0001271 xref: UMLS:C0032009 {source="BIRNLEX:1586"} @@ -235417,6 +340687,7 @@ xref: ZFA:0001271 is_a: UBERON:0003296 ! gland of diencephalon is_a: UBERON:0010134 {source="MA"} ! secretory circumventricular organ relationship: develops_from UBERON:0002346 ! neurectoderm +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000007 {source="ZFA"} ! pituitary gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG xsd:anyURI property_value: editor_note "request magnocellular cell from CL. Request oxytocin secretion from GO. Notes: 'The hypophysis or pituitary gland is derived, in part from an ectodermal outpocketing of the stomodeum (Rathke's Pouch) and in part from the floor of the diencephalon'" xsd:string {source="http://syllabus.med.unc.edu/courseware/embryo_images/"} @@ -235455,7 +340726,6 @@ xref: TAO:0000368 xref: VSAO:0000029 xref: Wikipedia:Integument xref: ZFA:0000368 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 {source="FMA"} ! organ system subdivision relationship: bounding_layer_of UBERON:0000468 ! multicellular organism @@ -235521,6 +340791,7 @@ id: UBERON:0002202 name: submucosa of trachea namespace: uberon def: "A submucosa that is part of a trachea." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "submucosa of windpipe" EXACT [OBOL:automatic] synonym: "submucous layer of trachea" RELATED [BTO:0002115] @@ -235536,13 +340807,17 @@ xref: SCTID:4419000 xref: UMLS:C0225586 {source="ncithesaurus:Trachea_Submucosa"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002203 name: vasculature of eye namespace: uberon def: "Vasculature that is part of the eye region." [https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726, OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "eye vascular network" EXACT [OBOL:automatic] @@ -235563,6 +340838,7 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: develops_from UBERON:0003314 {source="ISBN:0781772214"} ! eye mesenchyme relationship: part_of UBERON:0000019 ! camera-type eye +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "not part of the eye in ZFA. Note this changed to a blood vessel in ZFA" xsd:string {external_ontology="ZFA"} [Term] @@ -235593,10 +340869,12 @@ xref: Wikipedia:Musculoskeletal_system xref: XAO:0000168 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of_part_of GO:0040011 ! locomotion relationship: dc-contributor https://github.com/cmungall @@ -235666,11 +340944,11 @@ xref: EMAPA:35542 xref: FMA:74877 xref: GAID:652 xref: HBA:12909 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=412 {source="BIRNLEX:865"} xref: MA:0000174 xref: MBA:331 -xref: MESH:A08.186.211.730.385.357.362.500 +xref: MESH:D008326 xref: NCIT:C33052 +xref: neuronames:412 {source="BIRNLEX:865"} xref: SCTID:279306001 xref: TAO:0000334 xref: UMLS:C0024670 {source="BIRNLEX:865"} @@ -235763,6 +341041,12 @@ is_a: UBERON:0011134 {source="FMA"} ! nonsynovial joint relationship: has_part CL:0002320 {source="AEO"} ! connective tissue cell property_value: UBPROP:0000001 "A joint where fibrous tissue such as ligament connects two calcified tissues.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005156", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0002210 +name: syndesmosis +is_a: UBERON:0002209 ! fibrous joint +is_a: UBERON:0002213 ! cartilaginous joint + [Term] id: UBERON:0002211 name: nerve root @@ -235895,6 +341179,9 @@ xref: SCTID:42903008 xref: Wikipedia:Synchondrosis is_a: UBERON:0002209 ! fibrous joint is_a: UBERON:0002213 ! cartilaginous joint +intersection_of: UBERON:0002209 ! fibrous joint +intersection_of: composed_primarily_of UBERON:0001994 ! hyaline cartilage tissue +relationship: composed_primarily_of UBERON:0001994 ! hyaline cartilage tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/76/Gray297.png xsd:anyURI property_value: editor_note "consider adding link to hyaline cartilage" xsd:string property_value: editor_note "WP considers epiphyseal plates as subtypes of this" xsd:string @@ -235948,7 +341235,7 @@ is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: surrounded_by UBERON:0001484 ! articular capsule disjoint_from: UBERON:0011134 ! nonsynovial joint -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: surrounded_by UBERON:0001484 ! articular capsule property_value: UBPROP:0000001 "Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005153", ontology="TAO", source="ZFIN:Curator"} @@ -235981,7 +341268,7 @@ property_value: UBPROP:0000012 "in FMA, the tympanic ring is an anatomical line. id: UBERON:0002221 name: fontanelle namespace: uberon -def: "Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]." [Wikipedia:Fontanelle] +def: "Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]." [https://orcid.org/0000-0002-2825-0621, Wikipedia:Fontanelle] subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -235997,11 +341284,10 @@ xref: TAO:0001738 xref: UMLS:C0224548 {source="ncithesaurus:Fontanelle"} xref: Wikipedia:Fontanelle xref: ZFA:0005536 -is_a: CARO:0000000 ! anatomical entity -is_a: UBERON:0007651 {source="FMA"} ! anatomical junction +is_a: UBERON:0003685 ! cranial suture relationship: part_of UBERON:0001703 {source="MA", source="ZFA"} ! neurocranium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png xsd:anyURI -property_value: editor_note "TODO - check" xsd:string +property_value: seeAlso https://github.com/obophenotype/uberon/issues/1795 xsd:string property_value: UBPROP:0000001 "Anatomical structure that is a membranous gap between bones of the skull.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001738", ontology="TAO", source="TAO:wd"} [Term] @@ -236079,6 +341365,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0230139 xref: http://www.snomedbrowser.com/Codes/Details/243949006 xref: MA:0000032 xref: MESH:A01.911.800 +xref: MESH:D035423 xref: NCIT:C12905 xref: OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg xref: OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA @@ -236203,6 +341490,8 @@ xref: Wikipedia:Rib xref: ZFA:0000538 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0015019 ! rib endochondral element +intersection_of: UBERON:0015019 ! rib endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0006288 {evidence="definitional"} ! rib cartilage element property_value: UBPROP:0000001 "Endochondral bone that is intersegmental and rod-shaped, forming in the peritoneal membrane and attached to the vertebral parapophyses. Ribs protect and support internal organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000538", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Endochondral, rodlike element that articulates with the transverse process and parapophysis (double-headed rib), or with the transverse process only (single-headed rib); it extends into the body wall and provides a site for muscle attachment.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000545", ontology="AAO", source="AAO:Pugener_2002"} @@ -236278,7 +341567,7 @@ xref: EMAPA:35851 xref: FMA:75805 xref: GAID:876 xref: MA:0001199 -xref: MESH:A09.246.631.246.292.906 +xref: MESH:D013680 xref: NCIT:C33740 xref: SCTID:368960006 xref: UMLS:C0039432 {source="ncithesaurus:Tectorial_Membrane"} @@ -236313,6 +341602,9 @@ xref: SCTID:361325003 xref: UMLS:C0730117 {source="ncithesaurus:Proximal_Phalanx_of_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004302 ! proximal phalanx +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: proximally_connected_to UBERON:0002374 ! metacarpal bone [Term] id: UBERON:0002236 @@ -236328,6 +341620,7 @@ xref: BTO:0001721 xref: EMAPA:35262 xref: FMA:7591 xref: MA:0000106 +xref: MESH:D066186 xref: NCIT:C32391 xref: OpenCyc:Mx4rwP1g3pwpEbGdrcN5Y29ycA xref: SCTID:244703004 @@ -236338,6 +341631,14 @@ relationship: part_of UBERON:0002228 ! rib property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cc/Gray315.png xsd:anyURI property_value: editor_note "we currently model this as part of the rib, is this correct?" xsd:string +[Term] +id: UBERON:0002237 +name: true rib +is_a: UBERON:0002228 ! rib +intersection_of: UBERON:0002228 ! rib +intersection_of: connected_to UBERON:0000975 ! sternum +relationship: connected_to UBERON:0000975 ! sternum + [Term] id: UBERON:0002238 name: false rib @@ -236426,6 +341727,7 @@ xref: MAT:0000183 xref: MESH:D013116 xref: MIAA:0000183 xref: NCIT:C12464 +xref: neuronames:22 {source="BIRNLEX:1709"} xref: OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA xref: SCTID:180959008 xref: Spinal:cord @@ -236497,12 +341799,18 @@ xref: EMAPA:18008 xref: FMA:13550 xref: FMA:76703 xref: MA:0000112 +xref: MESH:D000070614 xref: SCTID:316586000 xref: Wikipedia:Nucleus_pulposus is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0001066 ! intervertebral disk relationship: develops_from UBERON:0002328 {editor="mah", source="ISBN:0073040584", source="Wikipedia"} ! notochord +relationship: has_part CHEBI:37397 ! chondroitin sulfate +relationship: has_part CHEBI:60924 ! keratan sulfate +relationship: has_part CL:0000138 ! chondrocyte +relationship: has_part UBERON:0011860 ! collection of collagen fibrils relationship: part_of UBERON:0001066 ! intervertebral disk property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png xsd:anyURI property_value: UBPROP:0000010 "The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[Wikipedia:Nucleus_pulposus]" xsd:string @@ -236573,10 +341881,10 @@ xref: DMBA:16920 xref: EMAPA:35218 xref: FMA:76925 xref: HBA:12930 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1214 xref: MA:0000200 xref: MBA:1073 xref: NCIT:C32726 +xref: neuronames:1214 xref: SCTID:362411002 xref: UMLS:C0228465 {source="ncithesaurus:Hemisphere_of_the_Cerebellum"} xref: Wikipedia:Cerebellar_hemisphere @@ -236602,6 +341910,9 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0015212 ! lateral structure +relationship: connected_to UBERON:0003889 ! fallopian tube +relationship: contributes_to_morphology_of UBERON:0000995 ! uterus +relationship: in_lateral_side_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 {source="MA"} ! uterus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/27/Illu_female_pelvis.jpg xsd:anyURI property_value: UBPROP:0000008 "The uterine horns are far more prominent in other animals than they are in humans" xsd:string {source="WP"} @@ -236627,7 +341938,7 @@ is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0006590 {source="FMA"} ! remnant of embryonic structure relationship: part_of UBERON:0002046 {source="MA", source="VHOG"} ! thyroid gland -property_value: depicted:by Illu08:thyroid.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fd/Illu08_thyroid.jpg xsd:anyURI property_value: UBPROP:0000001 "An embryonic duct extending between the thyroid primordium and the posterior tongue. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000746", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/thyroglossal+duct"} property_value: UBPROP:0000003 "A duct, called the thyroglossal duct in mammals, is considered to be characteristic of thyroid development. The thyroglossal duct, degenerating in many species during late development, marks the way the thyroid primordium relocates during embryonic development from the pharynx to its position deep in the cervical mesenchyme. We cannot exclude that the duct of the endostyle and the thyroglossal duct may have evolved independently, but as they both represent a more or less persistent connection of the organ to the pharynx, it is likely that they are homologous structures.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000746", ontology="VHOG", source="DOI:10.1007/s00427-004-0450-0 Kluge B, Renault N, Rohr KB, Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution. Development genes and evolution (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "FMA treats this as vestigial" xsd:string {external_ontology="FMA"} @@ -236654,9 +341965,9 @@ xref: EHDAA:7865 xref: EMAPA:17612 xref: FMA:77280 xref: GAID:354 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1566 xref: MA:0000289 -xref: MESH:A04.531.591.940 +xref: MESH:D019147 +xref: neuronames:1566 xref: SCTID:361346007 xref: VHOG:0000665 xref: Wikipedia:Vomeronasal_organ @@ -236705,9 +342016,9 @@ xref: BM:SpC-DH xref: EMAPA:18574 xref: EMAPA:35790 xref: FMA:256530 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1686 xref: MA:0001119 xref: NCIT:C32473 +xref: neuronames:1686 xref: SCTID:180961004 xref: TAO:0000649 xref: UMLS:C0228564 {source="BIRNLEX:2667"} @@ -236752,9 +342063,9 @@ xref: BTO:0005151 xref: EMAPA:18575 xref: EMAPA:35794 xref: FMA:256541 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1751 xref: MA:0001134 xref: NCIT:C33859 +xref: neuronames:1751 xref: SCTID:279443000 xref: TAO:0000702 xref: UMLS:C0228569 {source="BIRNLEX:2668"} @@ -236785,7 +342096,7 @@ synonym: "posterior funiculus" EXACT [] synonym: "posterior funiculus of spinal cord" EXACT [] synonym: "posterior white column of spinal cord" EXACT [FMA:77461] xref: FMA:77461 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1692 +xref: neuronames:1692 xref: SCTID:362432005 xref: TAO:0000501 xref: Wikipedia:Dorsal_funiculus @@ -236811,10 +342122,10 @@ xref: EMAPA:36556 xref: EV:0100244 xref: FMA:242157 xref: GAID:574 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1279 xref: MA:0002567 -xref: MESH:A08.186.211.132.659.237 +xref: MESH:D003336 xref: NCIT:C12461 +xref: neuronames:1279 xref: SCTID:361579006 xref: UMLS:C0010087 {source="ncithesaurus:Corpora_Quadrigemina"} xref: Wikipedia:Corpora_quadrigemina @@ -236855,15 +342166,15 @@ xref: BAMS:vrt xref: BTO:0000865 xref: FMA:5979 xref: FMA:77516 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2620 xref: NCIT:C33860 +xref: neuronames:2620 xref: NLXANAT:20090209 xref: TAO:0000705 xref: UMLS:C0205956 {source="ncithesaurus:Ventral_Nerve_Root"} xref: Wikipedia:Anterior_root_of_spinal_nerve xref: ZFA:0000705 is_a: UBERON:0009623 {different_relation_from="ZFA", source="FMA"} ! spinal nerve root -property_value: depicted:by Spinal:nerve.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: UBPROP:0000001 "The efferent motor root of a spinal nerve. At its distal end, the ventral root joins with the dorsal root to form a mixed spinal nerve[Wikipedia:Anterior_root_of_spinal_nerve]." xsd:string {source="Wikipedia:Anterior_root_of_spinal_nerve"} property_value: UBPROP:0000012 "FMA:77516 xref is a 'general anatomical term'. We xref both to ensure equivalence." xsd:string {external_ontology="FMA"} @@ -236893,8 +342204,8 @@ synonym: "sensory spinal root" RELATED [BTO:0000360] xref: BAMS:drt xref: BTO:0000360 xref: FMA:5980 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1661 xref: NCIT:C32477 +xref: neuronames:1661 xref: NLXANAT:20090208 xref: SCTID:362436008 xref: TAO:0000652 @@ -236902,7 +342213,7 @@ xref: UMLS:C0205955 {source="ncithesaurus:Dorsal_Root_of_the_Spinal_Nerve"} xref: Wikipedia:Posterior_root_of_spinal_nerve xref: ZFA:0000652 is_a: UBERON:0009623 {source="FMA"} ! spinal nerve root -property_value: depicted:by Spinal:nerve.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: UBPROP:0000001 "In anatomy and neurology, the dorsal root (or posterior root) is the afferent sensory root of a spinal nerve. At the distal end of the dorsal root is the dorsal root ganglion, which contains the neuron cell bodies of the nerve fibres conveyed by the root. If the dorsal root of a spinal nerve were severed it would lead to numbness in certain areas of the body. The lateral division of the dorsal root contains lightly myelinated and unmyelinated axons of small diameter. These transmit pain and temperature sensation from the body. These fibers cross through the anterior white commissure to form the Anterior lateral system in the lateral funiculus. The medial division of the dorsal root contains myelinated axons of larger diameter. These transmit information of discriminative touch, pressure, vibration, and conscious proprioception originating from spinal levels C2 through S5. These fibers are pushed in towards the posterior medial sulcus to form the fasciculus gracilis and the fasciculus cuneatus. [WP,unvetted][Wikipedia:Posterior_root_of_spinal_nerve]." xsd:string {source="Wikipedia:Posterior_root_of_spinal_nerve"} [Term] @@ -236910,6 +342221,7 @@ id: UBERON:0002264 name: olfactory bulb namespace: uberon def: "A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]." [BTO:0000961, Wikipedia:Olfactory_bulb] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -236933,10 +342245,10 @@ xref: EV:0100173 xref: FMA:77624 xref: GAID:633 xref: HBA:9303 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 {source="BIRNLEX:1137"} xref: MA:0000194 -xref: MESH:A08.186.211.577.699.573 +xref: MESH:D009830 xref: NCIT:C28401 +xref: neuronames:279 {source="BIRNLEX:1137"} xref: SCTID:279394006 xref: TAO:0000402 xref: UMLS:C0028936 {source="ncithesaurus:Olfactory_Bulb"} @@ -236948,11 +342260,15 @@ xref: ZFA:0000402 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0015212 ! lateral structure +relationship: capable_of GO:0007608 ! sensory perception of smell +relationship: contributes_to_morphology_of UBERON:0005366 ! olfactory lobe +relationship: in_lateral_side_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0005366 ! olfactory lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d2/1543%2CVesalius%27OlfactoryBulbs.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f9/1543,Vesalius%27OlfactoryBulbs.jpg xsd:anyURI property_value: RO:0002171 UBERON:0001950 {source="ABA"} property_value: RO:0002171 UBERON:0002421 {source="ABA"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Part of the rostral part of the cerebrum where axons of olfactory cells from the nasal mucosa terminate. Projects onto olfactory parts of pallium via olfactory tracts" xsd:string {source="ISBN:0471888893"} property_value: UBPROP:0000001 "Part of the telencephalon comprised of anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010165", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "Segment of neural tree organ which is continuous with a set of olfactory nerves and an olfactory tract[FMA:77624]." xsd:string {source="FMA:77624"} @@ -236967,6 +342283,7 @@ id: UBERON:0002265 name: olfactory tract namespace: uberon def: "White matter tract that contains projections from the olfactory bulb to other parts of the brain." [BIRNLEX:1663, http://orcid.org/0000-0002-6601-2165, ISBN:0471888893, Wikipedia:Olfactory_tract] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "olfactory peduncle" RELATED [BTO:0003647] @@ -236983,15 +342300,19 @@ xref: DHBA:12074 xref: EMAPA:35615 xref: FMA:77626 xref: HBA:9302 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=283 {source="BIRNLEX:1663"} xref: MA:0000975 xref: NCIT:C33207 +xref: neuronames:283 {source="BIRNLEX:1663"} xref: SCTID:362356008 xref: UMLS:C0162435 {source="ncithesaurus:Olfactory_Tract"} xref: Wikipedia:Olfactory_tract is_a: UBERON:0007702 ! tract of brain +intersection_of: UBERON:0007702 ! tract of brain +intersection_of: overlaps UBERON:0002264 ! olfactory bulb +relationship: overlaps UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0011299 ! white matter of telencephalon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A nervelike, white band composed primarily of nerve fibres originating from the mitral cells and tufted cells of the olfactory bulb but also containing the scattered cells of the anterior olfactory nucleus[BTO:0003647]." xsd:string {source="BTO:0003647"} property_value: UBPROP:0000001 "The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. It lies in the olfactory sulcus on the inferior surface of the frontal lobe, and divides posteriorly into two striæ, a medial olfactory stria and a lateral olfactory stria.[Wikipedia]." xsd:string {source="Wikipedia:Olfactory_tract"} property_value: UBPROP:0000001 "Tract of brain which is continuous with olfactory bulb and the cerebral cortex.[FMA]" xsd:string {source="FMA"} @@ -237019,7 +342340,13 @@ xref: FBbt:00005158 xref: FMA:77659 xref: VHOG:0000287 xref: XAO:0000273 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000020 ! sense organ +intersection_of: UBERON:0000020 ! sense organ +intersection_of: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: capable_of GO:0050911 ! detection of chemical stimulus involved in sensory perception of smell +relationship: has_part CL:0000207 ! olfactory receptor cell +relationship: overlaps UBERON:0005725 ! olfactory system property_value: editor_note "An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint" xsd:string property_value: UBPROP:0000012 "fma general anatomical term. xao has no subtypes (but Johnstons organ develops from this). An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint" xsd:string @@ -237028,6 +342355,7 @@ id: UBERON:0002270 name: hyaloid artery namespace: uberon def: "An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens." [Wikipedia:Hyaloid_artery] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -237049,8 +342377,13 @@ is_a: UBERON:0001637 {source="ZFA"} ! artery is_a: UBERON:0003499 ! brain blood vessel is_a: UBERON:0005492 ! hyaloid vessel relationship: develops_from UBERON:0001619 {source="EHDAA2"} ! ophthalmic artery +relationship: has_potential_to_develop_into UBERON:0006010 ! hyaloid canal +relationship: located_in UBERON:0005412 ! optic fissure +relationship: located_in UBERON:0005606 ! hyaloid cavity relationship: part_of UBERON:0003098 {source="Wikipedia"} ! optic stalk +relationship: supplies UBERON:0000965 ! lens of camera-type eye property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Artery that is internal to the eye. Isogai et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005045", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000008 "In humans, Usually fully regressed before birth, its purpose is to supply nutrient to the developing lens in the growing fetus. During the tenth week of development the lens grows independent of a blood supply and the hyaloid artery usually regresses. Its proximal portion remains as the central artery of the retina. Regression of the hyaloid artery leaves a clear central zone through the vitreous called the hyaloid canal or Cloquet's canal. Occasionally the artery may not fully regress, resulting in the condition persistent hyaloid artery. More commonly, small remnants of the artery may remain. Free remnants can sometimes be seen as 'floaters'. An anterior remnant of the hyaloid artery can be seen in some people as Mittendorf's dot, a small pinpoint-like scar on the posterior surface of the lens. A posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister's papilla" xsd:string @@ -237064,9 +342397,9 @@ synonym: "zona periventricularis hypothalamicae" EXACT LATIN [FMA:77682, FMA:TA] xref: BAMS:PVZ xref: EMAPA:35421 xref: FMA:77682 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2292 xref: MA:0000846 xref: MBA:157 +xref: neuronames:2292 xref: VHOG:0000623 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure @@ -237085,9 +342418,9 @@ xref: BAMS:MEZ xref: BAMS:MZ xref: EMAPA:35419 xref: FMA:77683 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2291 xref: MA:0000837 xref: MBA:467 +xref: neuronames:2291 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: part_of UBERON:0001898 ! hypothalamus @@ -237106,9 +342439,9 @@ synonym: "reticular formation of the brainstem" EXACT [NeuroNames:1223] xref: BAMS:RET xref: EMAPA:35188 xref: FMA:77719 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1223 xref: MA:0003185 xref: MESH:D012154 +xref: neuronames:1223 xref: NLX:143558 xref: SCTID:361552007 xref: Wikipedia:Reticular_formation @@ -237175,6 +342508,9 @@ xref: Wikipedia:Vestibular_aqueduct is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: conduit_for UBERON:0036074 ! vein of vestibular aqueduct +relationship: conduit_for UBERON:0036074 ! vein of vestibular aqueduct relationship: part_of UBERON:0005236 ! osseus labyrinth vestibule property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png xsd:anyURI @@ -237285,6 +342621,7 @@ namespace: uberon def: "A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Lateral_ventricle] comment: modeled as space in EHDAA2 subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -237314,11 +342651,11 @@ xref: EV:0100307 xref: FMA:78448 xref: GAID:611 xref: HBA:9419 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=209 xref: MA:0000192 xref: MBA:81 xref: MESH:D020547 xref: NCIT:C12834 +xref: neuronames:209 xref: OpenCyc:Mx4rvYsFdZwpEbGdrcN5Y29ycA xref: SCTID:180930008 xref: TAO:0000696 @@ -237329,9 +342666,12 @@ xref: Wikipedia:Lateral_ventricle xref: ZFA:0000696 is_a: UBERON:0004086 ! brain ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0004086 ! brain ventricle +intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon relationship: transformation_of UBERON:0009676 {notes="material to immaterial", source="EHDAA2"} ! early telencephalic vesicle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The lateral ventricles are part of the ventricular system of the brain. Classified as part of the telencephalon, they are the largest of the ventricles. The lateral ventricles connect to the central third ventricle through the interventricular foramina of Monro[WP]." xsd:string {source="Wikipedia:Lateral_ventricle"} property_value: UBPROP:0000001 "The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle[GO]." xsd:string {source="GO:0021670"} property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000643", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"} @@ -237361,11 +342701,11 @@ xref: EV:0100308 xref: FMA:78454 xref: GAID:614 xref: HBA:9420 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=446 xref: MA:0000182 xref: MBA:129 xref: MESH:D020542 xref: NCIT:C12827 +xref: neuronames:446 xref: OpenCyc:Mx4rvakhcJwpEbGdrcN5Y29ycA xref: SCTID:180931007 xref: TAO:0000161 @@ -237375,6 +342715,7 @@ xref: VHOG:0000007 xref: Wikipedia:Third_ventricle xref: ZFA:0000161 is_a: UBERON:0004086 ! brain ventricle +relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon relationship: develops_from UBERON:0006284 {source="EHDAA2"} ! early prosencephalic vesicle relationship: part_of UBERON:0001894 ! diencephalon property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png xsd:anyURI @@ -237383,6 +342724,14 @@ property_value: UBPROP:0000001 "Fluid-filled brain cavity. Kimmel et al, 1995.[T property_value: UBPROP:0000002 "relationship loss: develops_from forebrain ventricle (TAO:0001259)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000161", ontology="TAO"} property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000007", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0002288 +name: choroid plexus of third ventricle +is_a: UBERON:0001886 ! choroid plexus +intersection_of: UBERON:0001886 ! choroid plexus +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002286 ! third ventricle + [Term] id: UBERON:0002289 name: midbrain cerebral aqueduct @@ -237390,6 +342739,7 @@ namespace: uberon alt_id: UBERON:0005684 def: "Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone)." [BIRNLEX:1261] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -237427,12 +342777,12 @@ xref: EV:0100309 xref: FMA:78467 xref: GAID:583 xref: HBA:265505702 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=509 xref: MA:0000208 xref: MBA:140 -xref: MESH:A08.186.211.132.659.822.187 +xref: MESH:D002535 xref: NCIT:C32135 xref: ncithesaurus:Cerebral_Aqueduct +xref: neuronames:509 xref: SCTID:279249003 xref: TAO:0000159 xref: UMLS:C0007769 {source="BIRNLEX:1261"} @@ -237445,9 +342795,20 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre relationship: develops_from UBERON:0013148 {source="EHDAA2"} ! early midbrain vesicle relationship: part_of UBERON:0001891 ! midbrain property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/da/Cn3nucleus.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000832", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "Two distinct classes in ncit. We classify this as a brain ventricle even though it is not classifically regarded as one (3rd = diencephalon, 4th = hindbrains)" xsd:string {external_ontology="ncit"} +[Term] +id: UBERON:0002290 +name: choroid plexus of fourth ventricle +is_a: UBERON:0001886 ! choroid plexus +is_a: UBERON:0006694 ! cerebellum vasculature +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001886 ! choroid plexus +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002422 ! fourth ventricle + [Term] id: UBERON:0002291 name: central canal of spinal cord @@ -237455,6 +342816,7 @@ namespace: uberon alt_id: UBERON:0002220 def: "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [PMID:23409159, ZFIN:curator] comment: previously mapped to FMA:75364. Note some ontologies (NIF, SNOMED) subdivide this into lumbar, thoracic, etc. Note we follow FMA in distinguishing between the canal and the lumen +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -237473,10 +342835,10 @@ xref: EHDAA2:0004361 xref: EMAPA:35789 xref: FMA:78497 xref: HBA:9422 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1733 xref: MA:0001117 xref: MBA:164 xref: NCIT:C12891 +xref: neuronames:1733 xref: SCTID:279447004 xref: TAO:0000938 xref: UMLS:C0459414 {source="ncithesaurus:Central_Canal"} @@ -237485,10 +342847,14 @@ xref: ZFA:0000938 is_a: UBERON:0004111 {source="cjm"} ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: channel_for UBERON:0001359 ! cerebrospinal fluid +relationship: contributes_to_morphology_of UBERON:0002240 ! spinal cord relationship: develops_from UBERON:0001049 ! neural tube +relationship: has_part UBERON:0001359 ! cerebrospinal fluid relationship: part_of UBERON:0002240 {source="MA"} ! spinal cord relationship: part_of UBERON:0005281 {source="FMA"} ! ventricular system of central nervous system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002292 @@ -237535,6 +342901,11 @@ xref: UMLS:C0224683 {source="ncithesaurus:Costochondral_Joint"} xref: Wikipedia:Costochondral_joint is_a: UBERON:0002001 {source="MA"} ! joint of rib is_a: UBERON:0002215 ! synchondrosis +intersection_of: UBERON:0002215 ! synchondrosis +intersection_of: connects UBERON:0002236 ! costal cartilage +intersection_of: connects UBERON:0010424 ! distal segment of rib +relationship: connects UBERON:0002236 ! costal cartilage +relationship: connects UBERON:0010424 ! distal segment of rib property_value: UBPROP:0000008 "In humans, Joints between costal cartilages of ribs 6-9 are plane synovial joints. Articulation between costal cartilage of rib 9 and rib 10 is fibrous" xsd:string [Term] @@ -237553,7 +342924,21 @@ xref: MESH:D001659 xref: NCIT:C12678 xref: SCTID:361354009 xref: Wikipedia:Biliary_system +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 ! organ system subdivision +intersection_of: UBERON:0011216 ! organ system subdivision +intersection_of: capable_of GO:0006699 ! bile acid biosynthetic process +intersection_of: capable_of GO:0015721 ! bile acid and bile salt transport +intersection_of: has_part UBERON:0001173 ! biliary tree +disjoint_from: UBERON:0002330 ! exocrine system +disjoint_from: UBERON:0002390 ! hematopoietic system +disjoint_from: UBERON:0002405 ! immune system +disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system +disjoint_from: UBERON:0004456 ! entire sense organ system +relationship: capable_of GO:0006699 ! bile acid biosynthetic process +relationship: capable_of GO:0015721 ! bile acid and bile salt transport +relationship: has_part UBERON:0001173 ! biliary tree relationship: part_of UBERON:0002423 ! hepatobiliary system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI property_value: RO:0002171 UBERON:0016478 @@ -237600,6 +342985,7 @@ xref: TAO:0005130 xref: Wikipedia:Mesentery#Development xref: ZFA:0005130 is_a: UBERON:0006598 ! presumptive structure +relationship: has_potential_to_develop_into UBERON:0002095 ! mesentery relationship: part_of UBERON:0009664 {source="EHDAA2"} ! gut mesentery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png xsd:anyURI property_value: UBPROP:0000001 "The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005130", ontology="TAO", source="ZFIN:curator"} @@ -237641,6 +343027,7 @@ xref: MA:0000169 xref: MBA:343 xref: MESH:D001933 xref: NCIT:C12441 +xref: neuronames:236 {source="BIRNLEX:1565"} xref: SCTID:180925009 xref: TAO:0002156 xref: UMLS:C0006121 {source="ncithesaurus:Brain_Stem"} @@ -237668,6 +343055,7 @@ name: alveolus of lung namespace: uberon def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." [Wikipedia:Pulmonary_alveolus] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "alveoli" RELATED PLURAL [BTO:0000060] @@ -237692,8 +343080,14 @@ xref: VHOG:0001445 xref: Wikipedia:Pulmonary_alveolus is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003215 ! alveolus +intersection_of: part_of UBERON:0002048 ! lung +relationship: contains_process GO:0007585 ! respiratory gaseous exchange by respiratory system +relationship: contributes_to_morphology_of UBERON:0008874 ! pulmonary acinus +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0002169 {source="FMA"} ! alveolar sac -property_value: depicted:by Alveolus:diagram.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002301 @@ -237713,7 +343107,6 @@ is_a: UBERON:0022303 ! nervous system cell part layer is_a: UBERON:8440004 ! laminar subdivision of the cortex intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: part_of UBERON:0001950 ! neocortex -relationship: part_of UBERON:0001950 ! neocortex [Term] id: UBERON:0002302 @@ -237779,6 +343172,8 @@ xref: FMA:83678 xref: MA:0002429 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer +intersection_of: UBERON:0022303 ! nervous system cell part layer +intersection_of: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation relationship: part_of UBERON:0001885 ! dentate gyrus of hippocampal formation property_value: UBPROP:0000008 "the basic trilaminar structure of the dentate gyrus is common across all species studied, with relatively minimal phylogenetic variation[PMC2492885]" xsd:string @@ -237800,6 +343195,9 @@ xref: MA:0002427 xref: Wikipedia:Hippocampus_anatomy#Hippocampal_Cells_and_Layers is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer +intersection_of: UBERON:0016548 ! central nervous system gray matter layer +intersection_of: part_of UBERON:0002421 ! hippocampal formation +relationship: contributes_to_morphology_of UBERON:0002421 ! hippocampal formation relationship: part_of UBERON:0002421 ! hippocampal formation property_value: editor_note "TODO - check NIF xref" xsd:string @@ -237820,9 +343218,9 @@ xref: EHDAA2:0004449 xref: EMAPA:17769 xref: FMA:83711 xref: HBA:9708 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=218 xref: MA:0000961 xref: NCIT:C32309 +xref: neuronames:218 xref: NLX:32548 xref: SCTID:70064002 xref: TAO:0001447 @@ -237831,6 +343229,8 @@ xref: VHOG:0001376 xref: ZFA:0001447 is_a: UBERON:0001886 ! choroid plexus is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001886 ! choroid plexus +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle relationship: part_of UBERON:0002285 ! telencephalic ventricle [Term] @@ -237880,10 +343280,10 @@ xref: DMBA:17766 xref: EMAPA:35345 xref: FMA:83866 xref: HBA:9253 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=187 {source="BIRNLEX:1502"} xref: MA:0000949 xref: MBA:603 xref: NCIT:C32606 +xref: neuronames:187 {source="BIRNLEX:1502"} xref: SCTID:369096000 xref: UMLS:C0152315 {source="BIRNLEX:1502"} xref: UMLS:C0152315 {source="ncithesaurus:Fimbria"} @@ -237916,8 +343316,8 @@ xref: BIRNLEX:1444 xref: BTO:0001066 xref: EMAPA:35409 xref: FMA:83895 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=156 {source="BIRNLEX:1444"} xref: MA:0000956 +xref: neuronames:156 {source="BIRNLEX:1444"} is_a: UBERON:0002305 ! layer of hippocampus property_value: editor_note "this layer changes in its depthwise spatial relation across its extent" xsd:string @@ -237947,10 +343347,10 @@ xref: EHDAA2:0004474 xref: EMAPA:19051 xref: FMA:83902 xref: HBA:9101 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=465 {source="BIRNLEX:1032"} xref: MA:0000211 xref: MAT:0000451 xref: NCIT:C12460 +xref: neuronames:465 {source="BIRNLEX:1032"} xref: SCTID:362394008 xref: TAO:0001353 xref: UMLS:C0039433 {source="ncithesaurus:Tectum_Mesencephali"} @@ -237987,6 +343387,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0475853 xref: http://www.snomedbrowser.com/Codes/Details/279441003 xref: MA:0000002 xref: NCIT:C32696 +xref: neuronames:2619 xref: NLXANAT:100204 xref: SCTID:279441003 xref: UMLS:C0475853 {source="ncithesaurus:Gray_Matter_of_the_Spinal_Cord"} @@ -238016,9 +343417,10 @@ xref: AEO:0001011 xref: EMAPA:35927 xref: FMA:83929 xref: HBA:9218 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2870 xref: MA:0001135 +xref: MESH:D066127 xref: NCIT:C33892 +xref: neuronames:2870 xref: NLX:412 xref: NLXANAT:101177 xref: OpenCyc:Mx4rwOAsDZwpEbGdrcN5Y29ycA @@ -238033,7 +343435,7 @@ xref: ZFA:0001682 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: composed_primarily_of UBERON:0006135 ! myelinated nerve fiber property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg xsd:anyURI -property_value: depicted:by Spinal:nerve.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg xsd:anyURI property_value: UBPROP:0000001 "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929]." xsd:string {source="FMA:83929"} property_value: UBPROP:0000001 "Multi-tissue structure comprised largely of myelinated axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002142", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001764", ontology="VHOG", source="DOI:10.1038/nature09614 Nave KA, Myelination and support of axonal integrity by glia. Nature (2010)", source="http://bgee.unil.ch/"} @@ -238059,9 +343461,9 @@ xref: DMBA:16926 xref: EMAPA:35235 xref: FMA:83943 xref: HBA:9288 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=691 {source="BIRNLEX:1562"} xref: MA:0002430 xref: NCIT:C49217 +xref: neuronames:691 {source="BIRNLEX:1562"} xref: SCTID:362412009 xref: TAO:0002183 xref: UMLS:C0152381 {source="ncithesaurus:Cerebellum_White_Matter"} @@ -238102,6 +343504,7 @@ id: UBERON:0002319 name: mesangium namespace: uberon def: "The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries." [https://sourceforge.net/p/obo/foundational-model-of-anatomy-fma-requests/13/, Wikipedia:Mesangium] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BTO:0002494 @@ -238116,6 +343519,7 @@ is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0005215 ! kidney interstitium +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "mesangial" xsd:string property_value: UBPROP:0000012 "WP considers this the same as glomerular mesangium. In MA, glomerular and extraglomerular are distingsuished. FMA class has no definition and is a type of stroma, which is inconsistent with our classification of this here." xsd:string {external_ontology="MA"} @@ -238124,6 +343528,7 @@ id: UBERON:0002320 name: glomerular mesangium namespace: uberon def: "A thin membrane which helps to support the capillary loops in a renal glomerulus. It is connective tissue composed of mesangial cells - myofibroblasts phenotypically related to vascular smooth muscle cells (muscle, smooth, vascular), phagocytes and the mesangial extracellular matrix." [MESH:A05.810.453.736.520.380, Wikipedia:Glomerular_mesangium] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: EMAPA:27961 @@ -238131,13 +343536,14 @@ xref: EMAPA:28248 xref: FMA:84140 xref: GAID:430 xref: MA:0002606 -xref: MESH:A05.810.453.736.520.380 +xref: MESH:D005920 xref: SCTID:244574009 xref: Wikipedia:Glomerular_mesangium is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002319 ! mesangium relationship: part_of UBERON:0004190 {source="GO"} ! renal glomerulus vasculature +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002321 @@ -238291,6 +343697,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0028439 xref: http://www.snomedbrowser.com/Codes/Details/308820002 xref: MAT:0000281 xref: MESH:A16.254.610 +xref: MESH:D009672 xref: NCIT:C12463 xref: SCTID:308820002 xref: TAO:0000135 @@ -238300,7 +343707,6 @@ xref: VSAO:0000032 xref: Wikipedia:Notochord xref: XAO:0000055 xref: ZFA:0000135 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000481 {source="VSAO"} ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure @@ -238356,6 +343762,7 @@ xref: http://en.wikipedia.org/wiki/Somite xref: http://linkedlifedata.com/resource/umls/id/C0376449 xref: MAT:0000068 xref: MESH:A16.254.425.660.750 +xref: MESH:D019170 xref: MIAA:0000068 xref: NCIT:C34302 xref: TAO:0000155 @@ -238405,6 +343812,7 @@ is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: composed_primarily_of UBERON:0002365 ! exocrine gland relationship: existence_ends_during UBERON:0000066 ! fully formed stage @@ -238417,6 +343825,7 @@ namespace: uberon def: "The connecting cord from the developing embryo to the placenta." [ISBN:0-683-40008-8, MP:0001725, PMID:9144284, Wikipedia:Umbilical_cord] comment: See notes for connecting stalk subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "birth cord" RELATED [Wikipedia:Umbilical_cord] @@ -238435,7 +343844,7 @@ xref: EV:0100127 xref: FMA:85541 xref: GAID:517 xref: MAT:0000280 -xref: MESH:A16.254.789 +xref: MESH:D014470 xref: MIAA:0000280 xref: NCIT:C34320 xref: OpenCyc:Mx4rvyewDJwpEbGdrcN5Y29ycA @@ -238443,8 +343852,11 @@ xref: SCTID:280644003 xref: UMLS:C0041633 {source="ncithesaurus:Umbilical_Cord"} xref: Wikipedia:Umbilical_cord is_a: UBERON:0000478 ! extraembryonic structure +relationship: connects UBERON:0000922 ! embryo +relationship: connects UBERON:0001987 ! placenta relationship: develops_from UBERON:0007806 ! connecting stalk property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f3/Umbilicalcord.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP]." xsd:string {source="Wikipedia:Umbilical_cord"} property_value: UBPROP:0000007 "umbilical" xsd:string @@ -238454,6 +343866,7 @@ name: pulmonary trunk namespace: uberon def: "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." [http://orcid.org/0000-0002-6601-2165] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "main pulmonary artery" RELATED [Wikipedia:Pulmonary_artery] @@ -238469,10 +343882,12 @@ xref: NCIT:C116918 xref: OpenCyc:Mx4rv-6d0ZwpEbGdrcN5Y29ycA xref: VHOG:0001134 is_a: UBERON:0001637 {source="MA"} ! artery +relationship: connected_to UBERON:0002080 ! heart right ventricle relationship: continuous_with UBERON:0000948 ! heart relationship: continuous_with UBERON:0002080 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! heart right ventricle relationship: part_of UBERON:0008886 ! pulmonary vascular system -property_value: depicted:by Alveoli:diagram.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001134", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+trunk"} property_value: UBPROP:0000003 "As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001134", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"} @@ -238499,6 +343914,10 @@ xref: UMLS:C0227472 {source="ncithesaurus:Submandibular_Duct"} xref: Wikipedia:Submandibular_duct is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001837 ! duct of salivary gland +intersection_of: part_of UBERON:0001736 ! submandibular gland +relationship: channels_from UBERON:0001736 ! submandibular gland +relationship: contributes_to_morphology_of UBERON:0001736 ! submandibular gland relationship: part_of UBERON:0001736 ! submandibular gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray1024.png xsd:anyURI property_value: UBPROP:0000012 "FMA also has 'main submandibular duct' (FMA:59899)" xsd:string {external_ontology="FMA"} @@ -238508,6 +343927,7 @@ id: UBERON:0002335 name: macula densa namespace: uberon def: "The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus[GO]." [GO:0072024, Wikipedia:Macula_densa] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim xref: BTO:0003940 @@ -238521,6 +343941,7 @@ xref: Wikipedia:Macula_densa is_a: UBERON:0004211 ! nephron epithelium relationship: part_of UBERON:0002303 {source="MA"} ! juxtaglomerular apparatus relationship: part_of UBERON:0004135 {source="GO"} ! distal tubule +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "not part of a nephron or distal tubule in MA and FMA" xsd:string {external_ontology="MA"} [Term] @@ -238544,13 +343965,13 @@ xref: EV:0100305 xref: FMA:86464 xref: GAID:683 xref: HBA:9222 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=191 xref: MA:0000188 xref: MAT:0000286 xref: MBA:776 -xref: MESH:A08.186.211.730.885.362 +xref: MESH:D003337 xref: MIAA:0000286 xref: NCIT:C12446 +xref: neuronames:191 xref: OpenCyc:Mx4rvbNzdZwpEbGdrcN5Y29ycA xref: SCTID:362354006 xref: UMLS:C0010090 {source="ncithesaurus:Corpus_Callosum"} @@ -238559,12 +343980,97 @@ xref: VHOG:0001608 xref: Wikipedia:Corpus_callosum is_a: UBERON:0002473 {source="FMA-part_of", source="MA"} ! intercerebral commissure is_a: UBERON:0005340 {source="MP"} ! dorsal telencephalic commissure +relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon +relationship: only_in_taxon NCBITaxon:9347 ! Eutheria property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray733.png xsd:anyURI property_value: RO:0002161 NCBITaxon:9255 {source="Wikipedia"} property_value: UBPROP:0000001 "The largest commissure of the brain connecting the cerebral hemispheres. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001608", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/corpus+callosum"} property_value: UBPROP:0000003 "In addition to the anterior commissure, placental mammals have a phylogenetically new forebrain commissure, the corpus callosum, which primarily interconnects the neocortex of the cerebral hemispheres.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001608", ontology="VHOG", source="DOI:10.1111/j.1749-6632.1969.tb20447.x Ebner FF, A comparison of primitive forebrain organization in metatherian and eutherian mammals. Annals of the New York Academy of Sciences (1969)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "The corpus callosum is found only in placental mammals. other groups do have other brain structures that allow for communication between the two hemispheres, such as the anterior commissure, which serves as the primary mode of interhemispheric communication in marsupials." xsd:string {source="Wikipedia:Corpus_callosum#Species_Differences"} +[Term] +id: UBERON:0002337 +name: endometrial stroma +namespace: uberon +def: "The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle." [ncithesaurus:Endometrial_Stroma] +subset: human_reference_atlas +synonym: "endometrium stroma" EXACT [] +synonym: "stroma of endometrium" EXACT [] +xref: CALOHA:TS-1266 +xref: EMAPA:35310 +xref: FMA:86487 +xref: MA:0002734 +xref: NCIT:C32516 +xref: SCTID:254115004 +xref: UMLS:C0227849 {source="ncithesaurus:Endometrial_Stroma"} +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0001295 ! endometrium +relationship: part_of UBERON:0001295 ! endometrium +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002338 +name: lamina propria of bronchus +namespace: uberon +def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchi lamina propria" EXACT [OBOL:automatic] +synonym: "bronchi lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "bronchi lamina propria mucosae" EXACT [OBOL:automatic] +synonym: "bronchial lamina propria" RELATED [EMAPA:35194] +synonym: "bronchial trunk lamina propria" EXACT [OBOL:automatic] +synonym: "bronchial trunk lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "bronchial trunk lamina propria mucosae" EXACT [OBOL:automatic] +synonym: "bronchus lamina propria" EXACT [] +synonym: "bronchus lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "bronchus lamina propria mucosae" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of bronchi" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of bronchial trunk" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of bronchus" EXACT [OBOL:automatic] +synonym: "lamina propria mucosae of bronchi" EXACT [OBOL:automatic] +synonym: "lamina propria mucosae of bronchial trunk" EXACT [OBOL:automatic] +synonym: "lamina propria mucosae of bronchus" EXACT [OBOL:automatic] +synonym: "lamina propria of bronchi" EXACT [OBOL:automatic] +synonym: "lamina propria of bronchial trunk" EXACT [OBOL:automatic] +xref: EMAPA:35194 +xref: FMA:86619 +xref: MA:0001836 +xref: NCIT:C49212 +xref: UMLS:C1707054 {source="ncithesaurus:Bronchus_Lamina_Propria"} +is_a: UBERON:0000031 ! lamina propria of trachea +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0000410 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! bronchial mucosa + +[Term] +id: UBERON:0002339 +name: epithelium of lobar bronchus +is_a: UBERON:0000115 ! lung epithelium +is_a: UBERON:0002031 ! epithelium of bronchus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus + +[Term] +id: UBERON:0002340 +name: epithelium of main bronchus +is_a: UBERON:0002031 ! epithelium of bronchus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + +[Term] +id: UBERON:0002341 +name: epithelium of segmental bronchus +is_a: UBERON:0000115 ! lung epithelium +is_a: UBERON:0002031 ! epithelium of bronchus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002184 ! segmental bronchus +relationship: part_of UBERON:0002184 ! segmental bronchus + [Term] id: UBERON:0002342 name: neural crest @@ -238590,9 +344096,11 @@ xref: http://linkedlifedata.com/resource/umls/id/C0027789 xref: http://www.snomedbrowser.com/Codes/Details/361462002 xref: MAT:0000066 xref: MESH:A16.254.600 +xref: MESH:D009432 xref: MIAA:0000066 xref: NCIT:C34222 xref: Neural:crest +xref: neuronames:1366 xref: SCTID:361462002 xref: TAO:0000045 xref: UMLS:C0027789 {source="ncithesaurus:Neural_Crest"} @@ -238613,6 +344121,7 @@ relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC relationship: part_of UBERON:0002346 {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest", source="XAO"} ! neurectoderm relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png xsd:anyURI property_value: depicted:by Neural:Crest.png xsd:anyURI property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"} @@ -238653,6 +344162,7 @@ name: descending thoracic aorta namespace: uberon def: "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [MP:0009868] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim xref: EFO:0002527 xref: EMAPA:18605 @@ -238661,8 +344171,11 @@ xref: MA:0002572 xref: SCTID:181301002 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube +relationship: contributes_to_morphology_of UBERON:0001514 ! descending aorta +relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta relationship: part_of UBERON:0001514 ! descending aorta relationship: part_of UBERON:0001515 ! thoracic aorta +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002346 @@ -238687,6 +344200,7 @@ xref: EHDAA:1498 xref: EHDAA:255 xref: EMAPA:16073 xref: EV:0100004 +xref: FBbt:00001057 xref: FBbt:00001061 xref: FMA:87657 xref: http://en.wikipedia.org/wiki/Neuroectoderm @@ -238734,6 +344248,8 @@ is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003827 ! thoracic segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0013507 ! thoracic vertebra cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png xsd:anyURI property_value: UBPROP:0000008 "Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, they are distinguished by the presence of facets on the sides of the bodies for articulation with the heads of the ribs, and facets on the transverse processes of all, except the eleventh and twelfth, for articulation with the tubercles of the ribs" xsd:string @@ -238744,6 +344260,7 @@ name: epicardium namespace: uberon def: "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] def: "a region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -238764,6 +344281,7 @@ xref: VHOG:0000119 xref: Wikipedia:Epicardium xref: XAO:0000316 xref: ZFA:0005057 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: attaches_to UBERON:0002349 {source="FMA"} ! myocardium @@ -238771,6 +344289,7 @@ relationship: develops_from UBERON:0004160 ! proepicardium relationship: part_of UBERON:0000948 {source="multiple"} ! heart relationship: part_of UBERON:0002425 {source="FMA-inferred"} ! visceral serous pericardium property_value: editor_note "TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "External layer of the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005057", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The inner layer of the pericardium that is in contact with the surface of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010409", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000009 "The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium]" xsd:string @@ -238880,6 +344399,7 @@ name: sinoatrial node namespace: uberon def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [GO:0003163, Wikipedia:Sinoatrial_node] comment: WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -238915,10 +344435,11 @@ is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart relationship: capable_of GO:0002027 ! regulation of heart rate relationship: capable_of_part_of GO:0060048 ! cardiac muscle contraction relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart -relationship: in_taxon NCBITaxon:7742 ! Vertebrata +relationship: in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0002350 {source="ZFA"} ! conducting system of heart property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002352 @@ -238926,6 +344447,7 @@ name: atrioventricular node namespace: uberon def: "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." [UBERON:cjm, Wikipedia:Atrioventricular_node] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -238966,6 +344488,7 @@ relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of relationship: part_of UBERON:0002350 ! conducting system of heart property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001474", ontology="VHOG", source="DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", source="http://bgee.unil.ch/"} [Term] @@ -238973,6 +344496,7 @@ id: UBERON:0002353 name: bundle of His namespace: uberon def: "A part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers[GO]." [GO:0003166, GOC:mtg_heart] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "A-V bundle" RELATED [EMAPA:35152] @@ -238998,9 +344522,11 @@ xref: UMLS:C0006382 {source="ncithesaurus:Atrioventricular_Bundle"} xref: Wikipedia:Bundle_of_His is_a: UBERON:0010131 {source="cjm"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle +relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart relationship: part_of UBERON:0004146 {source="GO"} ! His-Purkinje system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b6/ECG_Principle_fast.gif xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002354 @@ -239058,6 +344584,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0030797 xref: http://www.snomedbrowser.com/Codes/Details/229765004 xref: MA:0000030 xref: MESH:A01.673 +xref: MESH:D010388 xref: NCIT:C12767 xref: OpenCyc:Mx4rvVjiTJwpEbGdrcN5Y29ycA xref: SCTID:229765004 @@ -239117,6 +344644,7 @@ xref: MA:0002739 xref: SCTID:243954002 xref: Serous:pericardium xref: Wikipedia:Serous_pericardium +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000042 ! serous membrane relationship: attaches_to UBERON:0002359 {source="FMA"} ! fibrous pericardium relationship: has_part UBERON:0002408 ! parietal serous pericardium @@ -239140,7 +344668,7 @@ xref: FMA:9584 xref: GAID:18 xref: galen:Peritoneum xref: MA:0000449 -xref: MESH:A01.047.025.600 +xref: MESH:D010537 xref: NCIT:C12770 xref: OpenCyc:Mx4rvjJ72ZwpEbGdrcN5Y29ycA xref: TAO:0005120 @@ -239223,7 +344751,7 @@ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: immediate_transformation_of UBERON:0007645 {source="Bgee:AN"} ! future meninx relationship: part_of UBERON:0010743 ! meningeal cluster -property_value: depicted:by Illu:meninges.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg xsd:anyURI property_value: UBPROP:0000001 "Membrane covering the brain and spinal cord. It is represented by a single layer in fishes, two in amphibians, reptiles and birds and three in mammals (named dura mater, arachnoid and pia mater). [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001295", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/meninges"} property_value: UBPROP:0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001295", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "meningeal" xsd:string @@ -239258,10 +344786,10 @@ xref: EMAPA:32663 xref: EV:0100315 xref: FMA:9590 xref: GAID:693 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1463 xref: MA:0001116 xref: MESH:D010841 xref: NCIT:C33321 +xref: neuronames:1463 xref: NLXANAT:090209 xref: OpenCyc:Mx4rvtesBZwpEbGdrcN5Y29ycA xref: RETIRED_EHDAA2:0001464 @@ -239269,6 +344797,8 @@ xref: SCTID:362305004 xref: UMLS:C0031869 {source="ncithesaurus:Pia_Mater"} xref: Wikipedia:Pia_mater is_a: UBERON:0000391 ! leptomeninx +relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/31/Gray770-en.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/65/Gray770.png xsd:anyURI property_value: editor_note "consider adding adjacency relationship to neuraxis (brain+spinal cord); however note that at this time the meninges may be considered part of the nervous system" xsd:string @@ -239291,16 +344821,18 @@ xref: EMAPA:32659 xref: EV:0100314 xref: FMA:9591 xref: GAID:688 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1464 xref: MA:0001114 xref: MESH:D001099 xref: NCIT:C32136 +xref: neuronames:1464 xref: NLXANAT:090208 xref: OpenCyc:Mx4rve5HlJwpEbGdrcN5Y29ycA xref: SCTID:362304000 xref: UMLS:C1510935 {source="ncithesaurus:Arachnoid_Membrane"} xref: Wikipedia:Arachnoid_mater is_a: UBERON:0000391 ! leptomeninx +relationship: composed_primarily_of GO:0071953 ! elastic fiber +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a0/Gray767.png xsd:anyURI property_value: RO:0002171 UBERON:0002049 {source="ISBN:0471888893"} @@ -239321,10 +344853,10 @@ xref: EMAPA:32664 xref: EV:0100313 xref: FMA:9592 xref: GAID:691 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1462 xref: MA:0001115 xref: MESH:D004388 xref: NCIT:C32488 +xref: neuronames:1462 xref: NLXANAT:090206 xref: OpenCyc:Mx4rvvmzqZwpEbGdrcN5Y29ycA xref: SCTID:362301008 @@ -239360,7 +344892,7 @@ xref: EV:0100358 xref: FMA:9595 xref: GAID:870 xref: MA:0000257 -xref: MESH:A09.246.397.873 +xref: MESH:D014432 xref: NCIT:C12502 xref: SCTID:181180005 xref: UMLS:C0041445 {source="ncithesaurus:Tympanic_Membrane"} @@ -239369,7 +344901,14 @@ xref: Wikipedia:Tympanic_membrane xref: XAO:0000212 is_a: UBERON:0000094 {source="FMA"} ! membrane organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: adjacent_to UBERON:0004114 ! tympanic cavity +relationship: contributes_to_morphology_of UBERON:0001756 ! middle ear relationship: develops_from UBERON:0009213 {source="Wikipedia"} ! pharyngeal membrane of 1st arch +relationship: has_part UBERON:0005042 ! inner epithelial layer of tympanic membrane +relationship: has_part UBERON:0010069 ! outer epithelial layer of tympanic membrane +relationship: has_part UBERON:0010070 ! intermediate layer of tympanic membrane +relationship: overlaps UBERON:0001352 ! external acoustic meatus +relationship: overlaps UBERON:0001691 ! external ear relationship: part_of UBERON:0001756 {source="MA"} ! middle ear property_value: RO:0002161 NCBITaxon:8459 {source="Wikipedia"} property_value: UBPROP:0000001 "The thin membrane which closes externally the cavity of the middle ear and is deeply sited at the bottom of the external auditory meatus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001146", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -239441,7 +344980,10 @@ xref: Wikipedia:Bulbourethral_gland is_a: UBERON:0006868 ! seminal fluid secreting gland is_a: UBERON:0010147 ! male accessory sex gland is_a: UBERON:0010186 ! male urethral gland -property_value: depicted:by Male:anatomy.png xsd:anyURI +relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia +relationship: produces UBERON:0004691 ! bulbourethral gland secretion +relationship: sexually_homologous_to UBERON:0000460 ! major vestibular gland +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png xsd:anyURI property_value: UBPROP:0000001 "Either of two small racemose glands that are located below the prostate and discharge a component of the seminal fluid into the urethra. They are homologous to the Bartholin's glands in the female[BTO]." xsd:string {ontology="BTO", source="BTO:0001698"} property_value: UBPROP:0000001 "Lobular organ the parenchyma of which consists of glandular acini which communicate the bulbar part of the urethra. Examples: There only two instances, right and left bulbo-urethral glands[FMA]" xsd:string {ontology="FMA", source="FMA:9599"} property_value: UBPROP:0000010 "The bulbourethral glands are compound tubulo-alveolar glands." xsd:string @@ -239453,6 +344995,7 @@ name: prostate gland namespace: uberon def: "The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [GO:0030850, Wikipedia:Prostate] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -239481,8 +345024,10 @@ xref: Wikipedia:Prostate is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0010147 ! male accessory sex gland relationship: develops_from UBERON:0003820 ! prostate bud +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg xsd:anyURI property_value: editor_note "TODO - FMA treats the gland as part of the prostate - see also FMA:74119." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "prostatic" xsd:string [Term] @@ -239561,6 +345106,8 @@ xref: XAO:0000164 is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0006858 ! adrenal/interrenal gland is_a: UBERON:0015212 ! lateral structure +relationship: has_developmental_contribution_from UBERON:0000926 ! mesoderm +relationship: in_lateral_side_of UBERON:0000949 ! endocrine system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg xsd:anyURI property_value: UBPROP:0000001 "Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010551", ontology="AAO", source="AAO:BJB"} @@ -239574,6 +345121,7 @@ name: thymus namespace: uberon def: "Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop." [NLM:thymus, Wikipedia:Thymus] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: organ_slim subset: pheno_slim @@ -239593,7 +345141,7 @@ xref: FMA:9607 xref: GAID:464 xref: MA:0000142 xref: MAT:0000080 -xref: MESH:A06.407.850 +xref: MESH:D013950 xref: MIAA:0000080 xref: NCIT:C12433 xref: OpenCyc:Mx4rvpIympwpEbGdrcN5Y29ycA @@ -239609,10 +345157,15 @@ is_a: UBERON:0002368 {source="EHDAA2"} ! endocrine gland is_a: UBERON:0004177 ! hemopoietic organ is_a: UBERON:0005057 ! immune organ is_a: UBERON:0005058 ! hemolymphoid system gland +relationship: contains_process GO:0030217 ! T cell differentiation relationship: develops_from UBERON:0005562 {source="ZFA"} ! thymus primordium +relationship: has_part UBERON:0003483 ! thymus lymphoid tissue +relationship: has_part UBERON:0003846 ! thymus epithelium +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata relationship: part_of UBERON:0000153 ! anterior region of body -property_value: depicted:by Illu:thymus.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg xsd:anyURI property_value: editor_note "check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010548", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000003 "A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000253", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.558", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "thymic" xsd:string @@ -239623,6 +345176,7 @@ name: bone marrow namespace: uberon def: "The soft tissue that fills the cavities of bones." [MGI:cwg, MP:0002397] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "medulla of bone" RELATED [BTO:0000141] @@ -239663,6 +345217,7 @@ relationship: part_of UBERON:0002405 ! immune system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg xsd:anyURI property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000009 "In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow]" xsd:string @@ -239682,10 +345237,10 @@ xref: EMAPA:35871 xref: EV:0100052 xref: FMA:9609 xref: GAID:341 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=671 xref: MA:0000143 -xref: MESH:A03.867.603.925 +xref: MESH:D014066 xref: NCIT:C12802 +xref: neuronames:671 xref: OpenCyc:Mx4rvVivrZwpEbGdrcN5Y29ycA xref: UMLS:C0836921 {source="ncithesaurus:Tonsil"} xref: UMLS:C1519547 {source="ncithesaurus:Tonsilar_Tissue"} @@ -239693,6 +345248,8 @@ xref: UMLS:C1519548 {source="ncithesaurus:Tonsillar_Lymphoid_Tissue"} xref: VHOG:0001139 xref: Wikipedia:Tonsil is_a: UBERON:0001962 ! gut-associated lymphoid tissue +relationship: contributes_to_morphology_of UBERON:0001735 ! tonsillar ring +relationship: located_in UBERON:0000167 ! oral cavity relationship: part_of UBERON:0001735 {source="cjm"} ! tonsillar ring property_value: IAO:0000232 "the term 'tonsil' can be ambiguous, sometimes refering specifically to the palatine tonsil, sometimes generically to include the cecal tonsils of avians. This class represents lymphoid tissue that is part of the tonsillar ring, in the mouth/throat region" xsd:string @@ -239713,6 +345270,7 @@ xref: EV:0100393 xref: FMA:9610 xref: MA:0000775 xref: MAT:0000291 +xref: MESH:D014066 xref: MIAA:0000291 xref: NCIT:C33250 xref: SCTID:265787001 @@ -239723,7 +345281,8 @@ is_a: UBERON:0002372 ! tonsil is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0010023 {notes="the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils; in rodents, the ventral portion of the second pouch appears to degenerate whereas the remaining part is incorporated into the lateral border of the pharynx; it appears that rodents no longer require tonsils as their function is carried out by the NALT (Nose/Nasal-Associated Lymphoid Tissue) system in the upper respiratory tract", source="ISBN:1607950324", source="MP:anna", source="PMID:20144910"} ! dorsal part of pharyngeal pouch 2 -property_value: depicted:by Illu:mouth.jpg xsd:anyURI +relationship: has_developmental_contribution_from UBERON:0002539 ! pharyngeal arch +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/f6/Illu_mouth.jpg xsd:anyURI property_value: RO:0002174 NCBITaxon:9989 {source="PMID:20144910"} property_value: UBPROP:0000011 "tonsillar fossa develops from dorsal portion of pouch 2. Note that pharyngeal and lingual tonsils do not develop from pharyngeal pouches" xsd:string {source="ISBN:1607950324"} @@ -239751,8 +345310,12 @@ is_a: UBERON:0003607 ! forelimb long bone is_a: UBERON:0003821 {is_inferred="true"} ! metapodium bone is_a: UBERON:0012358 ! manual digitopodium bone is_a: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0004453 ! metacarpus region +relationship: connected_to UBERON:0001435 ! carpal bone +relationship: connected_to UBERON:0001436 ! phalanx of manus relationship: part_of UBERON:0010544 ! metacarpus skeleton -property_value: depicted:by Metacarpals:numbered-en.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg xsd:anyURI [Term] id: UBERON:0002375 @@ -239776,7 +345339,7 @@ xref: EMAPA:18696 xref: FMA:9615 xref: GAID:110 xref: MA:0001762 -xref: MESH:A02.165.507.211 +xref: MESH:D003413 xref: NCIT:C32400 xref: SCTID:263484006 xref: UMLS:C0010323 {source="ncithesaurus:Cricoid_Cartilage"} @@ -239819,6 +345382,7 @@ xref: FMA:9616 xref: MA:0000578 xref: SCTID:244718003 xref: ZFA:0001652 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ @@ -239884,6 +345448,38 @@ intersection_of: part_of UBERON:0000916 ! abdomen relationship: part_of UBERON:0002343 {source="prolog"} ! abdomen musculature relationship: part_of UBERON:0003697 ! abdominal wall +[Term] +id: UBERON:0002379 +name: perineal muscle +namespace: uberon +def: "Any muscle organ that is part of a perineum [Automatically generated definition]." [OBOL:automatic] +synonym: "muscle of perineum" EXACT [] +synonym: "muscle organ of perineal region" EXACT [OBOL:automatic] +synonym: "muscle organ of perineum" EXACT [OBOL:automatic] +synonym: "perineal region muscle organ" EXACT [OBOL:automatic] +synonym: "perineum muscle organ" EXACT [OBOL:automatic] +xref: EMAPA:36629 +xref: FMA:9623 +xref: MA:0000538 +xref: NCIT:C33300 +xref: UMLS:C0224382 {source="ncithesaurus:Perineal_Muscle"} +is_a: UBERON:0001325 ! muscle of pelvis +relationship: part_of UBERON:0004486 {source="prolog"} ! musculature of perineum + +[Term] +id: UBERON:0002380 +name: trapezius muscle +is_a: UBERON:0001482 ! muscle of shoulder +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010313 ! neural crest-derived structure +relationship: develops_from UBERON:0010955 ! trapezius pre-muscle mass +relationship: has_muscle_antagonist UBERON:0001112 ! latissimus dorsi muscle +relationship: has_muscle_antagonist UBERON:0001125 ! serratus ventralis +relationship: has_muscle_insertion UBERON:0002497 ! acromion +relationship: has_muscle_insertion UBERON:0007173 ! lateral border of scapula +relationship: has_muscle_origin UBERON:0000351 ! nuchal ligament +relationship: has_muscle_origin UBERON:0001076 ! neural spine + [Term] id: UBERON:0002381 name: pectoralis major @@ -239908,7 +345504,7 @@ xref: Wikipedia:Pectoralis_major_muscle is_a: UBERON:0001482 ! muscle of shoulder is_a: UBERON:0001495 {source="FMA"} ! pectoral muscle is_a: UBERON:0003897 ! axial muscle -property_value: depicted:by Pectoralis:major.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png xsd:anyURI [Term] id: UBERON:0002382 @@ -239939,7 +345535,7 @@ is_a: UBERON:0002461 ! anterior abdominal wall muscle is_a: UBERON:0003897 ! axial muscle is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0008777 {source="XAO"} ! hypaxial musculature -property_value: depicted:by Rectus:abdominis.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/95/Rectus_abdominis.png xsd:anyURI property_value: UBPROP:0000008 "While the 'sixpack' is by far the most common configuration of the muscle bellies of the rectus, there exist rare anatomic variations which result in the appearance of eight ('eightpack'), ten, or-even rarer-asymmetrically arranged segments. All these variations are functionally equivalent" xsd:string [Term] @@ -239947,6 +345543,7 @@ id: UBERON:0002384 name: connective tissue namespace: uberon def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/23, PSPUB:0000170, VSAO:0000017] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -239979,6 +345576,7 @@ is_a: UBERON:0000479 ! tissue relationship: dc-contributor https://github.com/cmungall relationship: dc-contributor https://github.com/wdahdul relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000098", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001641", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000001 "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000017", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} @@ -240011,7 +345609,6 @@ xref: NCIT:C12435 xref: SCTID:91727004 xref: UMLS:C2328219 {source="ncithesaurus:Muscle_Tissue"} xref: Wikipedia:Muscle_tissue -is_a: BFO:0000040 ! material entity is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -240080,9 +345677,12 @@ xref: VSAO:0005058 xref: Wikipedia:Forearm is_a: UBERON:0002471 ! zeugopod is_a: UBERON:0008785 ! upper limb segment +intersection_of: UBERON:0002471 ! zeugopod +intersection_of: part_of UBERON:0002102 ! forelimb +relationship: has_skeleton UBERON:0010703 ! forelimb zeugopod skeleton relationship: part_of UBERON:0001460 {source="MA"} ! arm -property_value: depicted:by Forearm:labeled.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png xsd:anyURI property_value: UBPROP:0000001 "The middle forelimb region. [Evolution, Fourth_Edition_(2006)_Boston_etc.:_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.321, see_Kardong_KV][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000341", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000341", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group. TODO - add distinct term for skeleton and place AAO class here" xsd:string @@ -240127,7 +345727,10 @@ xref: VHOG:0000350 xref: Wikipedia:Pes_(anatomy) is_a: UBERON:0002470 ! autopod region is_a: UBERON:0008784 ! lower limb segment +intersection_of: UBERON:0002470 ! autopod region +intersection_of: part_of UBERON:0002103 ! hindlimb relationship: develops_from UBERON:0006871 ! embryonic footplate +relationship: has_skeleton UBERON:0001445 ! skeleton of pes property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ae/Male_Right_Foot_1.jpg xsd:anyURI property_value: UBPROP:0000007 "pedal" xsd:string @@ -240164,6 +345767,8 @@ xref: UMLS:C0016129 {source="ncithesaurus:Finger"} xref: Wikipedia:Finger xref: XAO:0003036 is_a: UBERON:0002544 ! digit +intersection_of: UBERON:0002544 ! digit +intersection_of: part_of UBERON:0002102 ! forelimb relationship: part_of UBERON:0012141 {source="PHENOSCAPE:ni"} ! manual digitopodium region relationship: part_of UBERON:5002389 ! manual digit plus metapodial segment property_value: UBPROP:0000001 "One of the fingers of the manus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000857", ontology="AAO", source="AAO:LAP"} @@ -240213,6 +345818,7 @@ is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: develops_from UBERON:0003061 {evidence="definitional"} ! blood island relationship: only_in_taxon NCBITaxon:7711 ! Chordata @@ -240242,7 +345848,7 @@ xref: GAID:1186 xref: galen:Lymph xref: MA:0002520 xref: MAT:0000055 -xref: MESH:A12.207.630 +xref: MESH:D008196 xref: MIAA:0000055 xref: NCIT:C13252 xref: OpenCyc:Mx4rvpDOU5wpEbGdrcN5Y29ycA @@ -240285,7 +345891,13 @@ is_a: UBERON:0000025 ! tube is_a: UBERON:0000058 ! duct is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland +relationship: connects UBERON:0001351 ! lacrimal sac +relationship: connects UBERON:0001707 ! nasal cavity +relationship: contributes_to_morphology_of UBERON:0001750 ! lacrimal apparatus relationship: develops_from UBERON:0006266 ! nasolacrimal groove +relationship: has_part CL:0000160 ! goblet cell +relationship: has_part UBERON:0007602 ! stratified columnar epithelium relationship: part_of UBERON:0001850 ! lacrimal drainage system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png xsd:anyURI property_value: UBPROP:0000003 "The nasolacrimal duct is probably homologous to the posterior (excurrent) naris of actinopterygian fishes.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000664", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.256", source="http://bgee.unil.ch/"} @@ -240321,6 +345933,8 @@ xref: Wikipedia:Eustachian_tube xref: XAO:0000213 is_a: UBERON:0000062 {source="FMA"} ! organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: has_developmental_contribution_from UBERON:0010020 ! tubotympanic recess epithelium +relationship: has_part UBERON:0010062 ! pharyngotympanic tube epithelium relationship: part_of UBERON:0001756 ! middle ear property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/40/Ear-anatomy-text-small-en.svg xsd:anyURI property_value: editor_note "we follow FMA in making this an organ, but include a separate class for the part that is epithelium, which is equivalent to the EHDAA2 structure. From this we infer the developmental relationship" xsd:string @@ -240362,6 +345976,10 @@ xref: ZFA:0001100 is_a: UBERON:0000025 ! tube is_a: UBERON:0003928 ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0001173 ! biliary tree +relationship: channel_for UBERON:0001970 ! bile +relationship: contributes_to_morphology_of UBERON:0001173 ! biliary tree relationship: develops_from UBERON:0008835 {source="XAO"} ! hepatic diverticulum relationship: part_of UBERON:0001173 {source="EMAPA", source="MA"} ! biliary tree property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png xsd:anyURI @@ -240389,13 +346007,13 @@ xref: FMA:9708 xref: GAID:196 xref: galen:Talus xref: MA:0001351 -xref: MESH:A02.835.232.300.710.780 +xref: MESH:D013628 xref: NCIT:C52799 xref: SCTID:182098005 xref: UMLS:C0039277 {source="ncithesaurus:Talus"} xref: Wikipedia:Talus_bone is_a: UBERON:0011679 ! proximal tarsal bone -property_value: depicted:by Subtalar:Joint.PNG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG xsd:anyURI property_value: UBPROP:0000008 "The talus is apparently derived from the fusion of three separate bones in the feet of primitive amphibians; the tibiale, articulating with tibia, the intermedium, between the bases of the tibia and fibula, and the fourth centrale, lying in the mid-part of the tarsus. These bones are still partially separate in modern amphibians, which therefore do not have a true talus. The talus forms a considerably more flexible joint in mammals than it does in reptiles. This reaches its greatest extent in artiodactyls, where the distal surface of the bone has a smooth keel to allow greater freedom of movement of the foot, and thus increase running speed" xsd:string {source="WP"} [Term] @@ -240411,6 +346029,7 @@ synonym: "vomer bone" EXACT [] xref: AAO:0000633 xref: FMA:9710 xref: MA:0001496 +xref: MESH:D055172 xref: NCIT:C33888 xref: OpenCyc:Mx4rv6jKWZwpEbGdrcN5Y29ycA xref: SCTID:272678009 @@ -240465,7 +346084,10 @@ is_a: UBERON:0008193 {source="FMA"} ! pneumatized bone is_a: UBERON:0008907 {source="VSAO"} ! dermal bone is_a: UBERON:0011597 ! bone of upper jaw is_a: UBERON:0015212 ! lateral structure +relationship: adjacent_to UBERON:0002244 ! premaxilla +relationship: contributes_to_morphology_of UBERON:0001708 ! jaw skeleton relationship: develops_from UBERON:0010334 {source="EHDAA2"} ! maxillary process mesenchyme from neural crest +relationship: in_lateral_side_of UBERON:0011156 ! facial skeleton relationship: part_of UBERON:0003113 {notes="facial series", source="ISBN:0073040584"} ! dermatocranium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png xsd:anyURI property_value: UBPROP:0000001 "Dermal bone that forms part of the upper jaw, located antero-ventral to the premaxilla. The maxilla is a paired bone.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000270", ontology="TAO", source="TAO:GA_TG"} @@ -240513,7 +346135,10 @@ xref: VHOG:0000344 xref: Wikipedia:Manus_(anatomy) is_a: UBERON:0002470 ! autopod region is_a: UBERON:0008785 ! upper limb segment +intersection_of: UBERON:0002470 ! autopod region +intersection_of: part_of UBERON:0002102 ! forelimb relationship: develops_from UBERON:0006875 ! embryonic handplate +relationship: has_skeleton UBERON:0001442 ! skeleton of manus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/76/LeftHand0.jpg xsd:anyURI property_value: IAO:0000232 "like all limb segments, this class encompasses both the unformed hand region of the embryo to the fully formed structure complete with skeleton" xsd:string property_value: UBPROP:0000007 "manual" xsd:string @@ -240536,6 +346161,7 @@ xref: SCTID:361998003 xref: UMLS:C0225777 {source="ncithesaurus:Parietal_Pleura"} xref: VHOG:0001495 xref: Wikipedia:Parietal_pleura +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -240551,6 +346177,7 @@ id: UBERON:0002401 name: visceral pleura namespace: uberon def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "lung mesothelium" RELATED [EHDAA2:0002205] @@ -240569,6 +346196,7 @@ xref: OpenCyc:Mx4rwNFqppwpEbGdrcN5Y29ycA xref: SCTID:361997008 xref: UMLS:C0225776 {source="ncithesaurus:Visceral_Pleura"} xref: VHOG:0001496 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0004923 ! organ component layer @@ -240579,6 +346207,7 @@ relationship: attaches_to UBERON:0008946 ! lung parenchyma relationship: contributes_to_morphology_of UBERON:0000977 ! pleura relationship: part_of UBERON:0000977 ! pleura relationship: part_of UBERON:0002048 {source="FMA"} ! lung +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]." xsd:string {source="Wikipedia:Visceral_pleura"} property_value: UBPROP:0000012 "FMA treats this as part of the lungs" xsd:string {external_ontology="FMA"} @@ -240599,7 +346228,7 @@ xref: EMAPA:16774 xref: FMA:9740 xref: GAID:95 xref: MA:0000055 -xref: MESH:A01.911.800.650 +xref: MESH:D035422 xref: NCIT:C12840 xref: OpenCyc:Mx4rwCKAppwpEbGdrcN5Y29ycA xref: SCTID:361999006 @@ -240624,6 +346253,7 @@ id: UBERON:0002405 name: immune system namespace: uberon def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [Wikipedia:Immune_system] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -240645,10 +346275,12 @@ xref: XAO:0003152 xref: ZFA:0001159 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: capable_of GO:0002376 ! immune system process relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: protects UBERON:0000468 ! multicellular organism +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001247", ontology="VHOG", source="PMID:21046016 Dzik JM, The ancestry and cumulative evolution of immune reactions. Acta biochimica Polonica (2010)", source="http://bgee.unil.ch/"} [Term] @@ -240713,7 +346345,6 @@ xref: VHOG:0001280 xref: Wikipedia:Pericardium xref: XAO:0004182 xref: ZFA:0000054 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000481 ! multi-tissue structure relationship: has_part UBERON:0002359 ! fibrous pericardium @@ -240770,6 +346401,7 @@ subset: uberon_slim xref: BTO:0001016 xref: FMA:9887 xref: MA:0002530 +xref: MESH:D000069236 xref: Pericardial:fluid xref: Wikipedia:Pericardial_fluid is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland @@ -240805,10 +346437,10 @@ xref: EHDAA:3767 xref: EMAPA:16984 xref: FMA:65553 xref: GAID:706 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2054 xref: MA:0000219 xref: MESH:D001341 xref: NCIT:C12673 +xref: neuronames:2054 xref: SCTID:362481007 xref: TAO:0001574 xref: UMLS:C0004388 {source="ncithesaurus:Autonomic_Nervous_System"} @@ -240820,7 +346452,7 @@ xref: ZFA:0001574 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000010 {source="EMAPA", source="MA", source="NIFSTD", source="ZFA-modified-from-isa"} ! peripheral nervous system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png xsd:anyURI property_value: UBPROP:0000001 "Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000396", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -240854,7 +346486,9 @@ xref: Wikipedia:Clitoris is_a: UBERON:0000062 {source="Wikipedia"} ! organ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +relationship: contributes_to_morphology_of UBERON:0005056 ! external female genitalia relationship: develops_from UBERON:0005876 {source="EHDAA2", source="Wikipedia"} ! undifferentiated genital tubercle +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000997 {source="MA"} ! mammalian vulva property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/cf/Clitoris_anatomy_labeled-en.svg xsd:anyURI property_value: UBPROP:0000007 "clitoral" xsd:string @@ -240888,6 +346522,8 @@ xref: ZFA:0001189 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0008001 {source="FMA"} ! irregular bone is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0011094 ! vertebra cartilage element property_value: editor_note "Consider changing name to make distinction from inferred superclass 'vertebral element' clear" xsd:string property_value: editor_note "we follow FMA in making this an irregular bone - however vertebra have 'epiphyses' which are currently classified as belonging to long bones" xsd:string @@ -240918,6 +346554,8 @@ is_a: UBERON:0003458 ! neck bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0004451 {is_inferred="true"} ! trunk or cervical vertebra is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0013505 ! cervical vertebra cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg xsd:anyURI property_value: UBPROP:0000008 "In some species, some parts of the skull may be composed of vertebra-like elements, e.g. the occipital bone in humans is composed of four vertebra-like segments. In many vertebrate species, cervical vertebrae are variable in number; however, almost all mammals have seven (including those with very short necks relative to body size, such as elephants or whales, and those with very long necks, such as giraffes). The few exceptions include the manatee and the sloths, of which the two-toed sloth has six cervical vertebrae and the three-toed sloth has up to nine cervical vertebrae. In many species, though not in mammals, the cervical vertebrae bear ribs. In many other groups, such as lizards and saurischian dinosaurs, the cervical ribs are large; in birds they are small and completely fused to the vertebrae. The transverse processes of mammals are homologous to the cervical ribs of other amniotes. Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, cervical vertebrae are the smallest of the true vertebrae, and can be readily distinguished from those of the thoracic or lumbar regions by the presence of a foramen (hole) in each transverse process, through which passes the vertebral artery." xsd:string @@ -240945,6 +346583,8 @@ is_a: UBERON:0002412 ! vertebra is_a: UBERON:0003828 ! abdominal segment bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0015009 ! lumbar vertebra endochondral element +intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0013509 ! lumbar vertebra cartilage element property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c8/Gray93.png xsd:anyURI property_value: UBPROP:0000008 "Whereas all rats had six lumbar vertebrae, variable patterns in mice included mostly five vertebrae in DBA/2J, mostly six vertebrae in C57BL/6J, and a mix in B6129PF2/J" xsd:string {source="PMCID:PMC2700063"} @@ -240972,6 +346612,7 @@ xref: OpenCyc:Mx4rvVjiC5wpEbGdrcN5Y29ycA xref: WBbt:0005741 xref: Wikipedia:Tail is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria relationship: part_of UBERON:0000154 ! posterior region of body property_value: editor_note "Note we also have a subclass post-anal tail, for the chordate specific structure. currently defined very generally, inclusive of caudal fin" xsd:string property_value: RO:0002161 NCBITaxon:9606 @@ -241023,6 +346664,7 @@ xref: Wikipedia:Integumentary_system xref: XAO:0000176 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system relationship: bounding_layer_of UBERON:0000468 ! multicellular organism relationship: dc-contributor https://github.com/cmungall @@ -241097,7 +346739,6 @@ xref: VSAO:0000040 xref: Wikipedia:Cartilage xref: XAO:0000170 xref: ZFA:0005622 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0002481 {source="https://github.com/obophenotype/uberon/issues/117"} ! bone tissue disjoint_from: UBERON:0002481 {source="https://github.com/obophenotype/uberon/issues/117"} ! bone tissue @@ -241186,15 +346827,16 @@ xref: DHBA:10294 xref: EMAPA:35405 xref: FMA:74038 xref: HBA:4249 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=177 {source="BIRNLEX:715"} xref: MA:0000189 xref: MBA:1089 +xref: neuronames:177 {source="BIRNLEX:715"} xref: PBA:4003 xref: SCTID:422867004 xref: UMLS:C0175202 {source="BIRNLEX:715"} xref: Wikipedia:Hippocampal_formation is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000956 {source="MBA-indirect", source="NIFSTD"} ! cerebral cortex property_value: IAO:0000232 "The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum" xsd:string {source="NIF"} property_value: RO:0002171 UBERON:0002264 {source="ABA"} @@ -241205,6 +346847,7 @@ id: UBERON:0002422 name: fourth ventricle namespace: uberon def: "Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures." [BIRNLEX:1256] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -241235,11 +346878,11 @@ xref: EV:0100310 xref: FMA:78469 xref: GAID:610 xref: HBA:9421 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=621 xref: MA:0000196 xref: MBA:145 xref: MESH:D020546 xref: NCIT:C12828 +xref: neuronames:621 xref: OpenCyc:Mx4rv-7Q6pwpEbGdrcN5Y29ycA xref: SCTID:180932000 xref: TAO:0000110 @@ -241250,9 +346893,13 @@ xref: XAO:0003099 xref: ZFA:0000110 is_a: UBERON:0004086 ! brain ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0004086 ! brain ventricle +intersection_of: part_of UBERON:0002028 ! hindbrain +relationship: contributes_to_morphology_of UBERON:0002028 ! hindbrain relationship: develops_from UBERON:0013149 {source="EHDAA2"} ! hindbrain vesicle relationship: part_of UBERON:0002028 ! hindbrain property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000110", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "Irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011043", ontology="AAO", source="UBERON:0002422"} property_value: UBPROP:0000001 "The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space[GO][GO:0021592]." xsd:string {source="GO:0021592"} @@ -241287,7 +346934,14 @@ xref: VHOG:0000294 xref: Wikipedia:Hepatobiliary_system xref: XAO:0000132 xref: ZFA:0000036 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011216 ! organ system subdivision +disjoint_from: UBERON:0004456 ! entire sense organ system +relationship: capable_of GO:0061007 ! hepaticobiliary system process +relationship: existence_ends_during UBERON:0000066 ! fully formed stage +relationship: has_part UBERON:0002107 ! liver +relationship: has_part UBERON:0002294 ! biliary system +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001007 ! digestive system property_value: UBPROP:0000001 "System responsible for the production and movement of bile[ZFIN:curator]." xsd:string {source="ZFIN:curator"} property_value: UBPROP:0000009 "The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. The parts are: liver, bile duct, gall bladder and hepatic duct [GO:0061008]" xsd:string @@ -241353,6 +347007,7 @@ xref: SCTID:243955001 xref: VHOG:0000538 xref: Visceral:pericardium xref: Wikipedia:Visceral_pericardium +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: part_of UBERON:0002357 ! serous pericardium @@ -241361,6 +347016,22 @@ relationship: contributes_to_morphology_of UBERON:0002407 ! pericardium relationship: has_part UBERON:0002348 {source="cjm"} ! epicardium relationship: part_of UBERON:0002357 ! serous pericardium +[Term] +id: UBERON:0002426 +name: chest muscle +is_a: UBERON:0003830 ! thoracic segment muscle +is_a: UBERON:0005175 ! chest organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001443 ! chest + +[Term] +id: UBERON:0002427 +name: arm skin +is_a: UBERON:0003531 ! forelimb skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001460 ! arm +relationship: part_of UBERON:0001460 ! arm + [Term] id: UBERON:0002428 name: limb bone @@ -241403,6 +347074,8 @@ xref: SCTID:181757009 xref: UMLS:C0588054 {source="ncithesaurus:Cervical_Lymph_Node"} xref: Wikipedia:Cervical_lymph_nodes is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg xsd:anyURI @@ -241431,8 +347104,8 @@ xref: EHDAA2:0001417 xref: EHDAA:8765 xref: EMAPA:17516 xref: FMA:74632 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=409 xref: MA:0000855 +xref: neuronames:409 xref: SCTID:245534008 xref: TAO:0001197 xref: VHOG:0001178 @@ -241494,11 +347167,11 @@ xref: EHDAA:7538 xref: EMAPA:17520 xref: FMA:74635 xref: HBA:9358 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=405 {source="BIRNLEX:1248"} -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=408 {source="BIRNLEX:912"} xref: MA:0000858 xref: NCIT:C32228 xref: NCIT:C45912 +xref: neuronames:405 {source="BIRNLEX:1248"} +xref: neuronames:408 {source="BIRNLEX:912"} xref: SCTID:245529009 xref: SCTID:425300001 xref: TAO:0001199 @@ -241511,6 +347184,9 @@ xref: Wikipedia:Pituitary_stalk xref: XAO:0004210 xref: ZFA:0001199 is_a: UBERON:0002616 ! regional part of brain +relationship: connects UBERON:0001898 ! hypothalamus +relationship: connects UBERON:0002198 ! neurohypophysis +relationship: contributes_to_morphology_of UBERON:0002198 ! neurohypophysis relationship: part_of UBERON:0002198 {source="NIFSTD"} ! neurohypophysis relationship: part_of UBERON:0002198 {inconsistent_with="NIFSTD", source="FMA", source="MA", source="ZFA"} ! neurohypophysis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG xsd:anyURI @@ -241548,12 +347224,12 @@ xref: EMAPA:17549 xref: FMA:77618 xref: FMA:83683 xref: HBA:4277 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=225 {source="BIRNLEX:1672"} xref: MA:0000891 xref: MBA:477 -xref: MESH:A08.186.211.730.885.105.487.550 +xref: MESH:D017072 xref: NCIT:C111122 xref: ncithesaurus:Striatum +xref: neuronames:225 {source="BIRNLEX:1672"} xref: PBA:10080 xref: UMLS:C0162512 {source="BIRNLEX:1672"} xref: Wikipedia:Striatum @@ -241570,21 +347246,11 @@ property_value: UBPROP:0000012 "FMA divides 'striatum of neuraxis' into 4, neost id: UBERON:0002436 name: primary visual cortex namespace: uberon -def: "A subdivision of the cytoarchitecturally defined occipital region of cerebral cortex in the human. Defined by the band of Gennari, which gives it the name striate (furrowed) area, it occupies the banks of the calcarine sulcus which are located in the cuneus and the lingual gyrus of the occipital lobe. Cytoarchitecturally it is bounded by the area 18 of Brodmann (human) which surrounds it ( Brodmann-1909 ). In the mouse ( Paxinos-2001 ) and the rat ( Swanson-1998 ) it is located on the dorsolateral surface of the cerebral hemisphere[BrainInfo]." [BrainInfo:2102] +def: "The visual area of the brain that is specialized for processing information about static and moving objects. The primary visual cortex, which is defined by its function or stage in the visual system, is approximately equivalent to the striate cortex, also known as Brodmann area 17, which is defined by its anatomical location." [WikipediaVersioned:Visual_cortex&oldid=1069729211] +comment: In some species, parcellations of lobes are not well defined if at all. The primary visual cortex being part of the occiptal lobe hence could refer to it being part of the most posterior region of the mammalian cerebral cortex. subset: pheno_slim subset: uberon_slim -synonym: "area 17 of Brodmann" RELATED [Wikipedia:Visual_cortex] -synonym: "area 17 of Brodmann-1909" EXACT [BIRNLEX:1748] synonym: "area striata" RELATED [] -synonym: "B09-17" BROAD ABBREVIATION [BIRNLEX:1748, NIFSTD:SumsDB_abbrevSource] -synonym: "b09-17" EXACT [BIRNLEX:1748] -synonym: "BA17" EXACT ABBREVIATION [] -synonym: "BA17" RELATED ABBREVIATION [] -synonym: "BA17" RELATED [Wikipedia:Visual_cortex] -synonym: "Brodmann (1909) area 17" EXACT [BIRNLEX:1748] -synonym: "Brodmann area 17" EXACT [Wikipedia:Visual_cortex] -synonym: "Brodmann area 17" RELATED [Wikipedia:Visual_cortex] -synonym: "Brodmann area 17, striate" EXACT [BIRNLEX:1748] synonym: "calcarine cortex" RELATED [BrainInfo:2102] synonym: "nerve X" RELATED [NeuroNames:702] synonym: "occipital visual neocortex" RELATED [GEO:GSM336648] @@ -241599,26 +347265,19 @@ synonym: "visual association cortex" RELATED [Wikipedia:Visual_cortex] xref: BAMS:17 xref: BAMS:V1 xref: BAMS:VISp -xref: BIRNLEX:1748 xref: BM:Tel-Cx-V1 xref: BTO:0004703 xref: EMAPA:35708 xref: FMA:236871 xref: FMA:68614 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 {source="BIRNLEX:1748"} xref: MA:0000914 xref: MBA:385 xref: NCIT:C97340 +xref: neuronames:702 {source="BIRNLEX:1748"} xref: NLX:143552 -xref: PBA:10026 -xref: SCTID:384772005 xref: UMLS:C0038446 {source="ncithesaurus:Primary_Visual_Cortex"} -xref: UMLS:C1272535 {source="BIRNLEX:1748"} -is_a: UBERON:0013529 {source="FMA"} ! Brodmann area -is_a: UBERON:0035014 {source="NIFSTD"} ! functional part of brain +is_a: UBERON:8440011 ! cortical visual area relationship: part_of UBERON:0000411 {source="WP"} ! visual cortex -property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/70/Brodmann_areas_17_18_19.png xsd:anyURI -property_value: UBPROP:0000012 "We explicitly merge two FMA classes here, as BA17 is equivalent to V1. In future these may be separated into functional and cytoarchitecturally defined regions with an overlaps relationship between them" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0002437 @@ -241640,9 +347299,9 @@ xref: EMAPA:35237 xref: FMA:241998 xref: FMA:256174 xref: FMA:61822 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=189 {source="BIRNLEX:711"} xref: MA:0000945 xref: NCIT:C49347 +xref: neuronames:189 {source="BIRNLEX:711"} xref: SCTID:361691006 xref: UMLS:C0152295 {source="ncithesaurus:Cerebral_White_Matter"} xref: UMLS:C0152295 {source="BIRNLEX:711"} @@ -241659,6 +347318,7 @@ id: UBERON:0002439 name: myenteric nerve plexus namespace: uberon def: "One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility." [NLXANAT:100306] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "Auberbach plexus" EXACT [NLXANAT:100306] @@ -241686,6 +347346,7 @@ xref: UMLS:C0027028 {source="ncithesaurus:Myenteric_Nerve_Plexus"} xref: Wikipedia:Auerbach's_plexus is_a: UBERON:0000429 ! enteric plexus relationship: part_of UBERON:0012367 {source="FMA"} ! muscle layer of intestine +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses[MP][MP:0010801]." xsd:string {source="MP:0010801"} property_value: UBPROP:0000012 "note that FMA uses Meissner's plexus as a synonym, rather than separate class" xsd:string {external_ontology="FMA"} @@ -241745,6 +347406,7 @@ id: UBERON:0002444 name: lens fiber namespace: uberon def: "A region of the lens consisting of packed elongated enucleate cells packed with crystallin." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim synonym: "fibrae lentis" EXACT LATIN [FMA:76827, FMA:TA] synonym: "lens fibers" EXACT [] @@ -241768,15 +347430,26 @@ xref: XAO:0004096 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ relationship: part_of UBERON:0000965 ! lens of camera-type eye +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Fibres resembling a ribbon and arranged in very thin plates in the lens. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000444", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "(...) the line, or Y, or star sutures common to mammalian lenses, including those of primates. In the case of line or Y sutures, the overlapping of lens fibers in each successive shell is coincident and results in the formation of four or six three-dimensional suture planes that extend from the lens nucleus to the periphery.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000444", ontology="VHOG", source="DOI:10.1167/iovs.03-0466 Sivak JG, Through the lens clearly: phylogeny and development, The Proctor lecture. Investigative ophthalmology and visual science (2004)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0002445 +name: ulnare +is_a: UBERON:0001480 ! proximal carpal bone +intersection_of: UBERON:0001480 ! proximal carpal bone +intersection_of: proximally_connected_to UBERON:0001424 ! ulna +relationship: BSPO:0001115 UBERON:0009880 ! carpal skeleton +relationship: proximally_connected_to UBERON:0001424 ! ulna + [Term] id: UBERON:0002446 name: patella namespace: uberon def: "A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad]." [https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=3470151&group_id=76834, PHENOSCAPE:ad] comment: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella. +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "knee bone" RELATED [FMA:24485] @@ -241787,7 +347460,7 @@ xref: FMA:24485 xref: GAID:203 xref: galen:Patella xref: MA:0001374 -xref: MESH:A02.835.232.500.624 +xref: MESH:D010329 xref: NCIT:C33282 xref: SCTID:182083008 xref: UMLS:C0030647 {source="ncithesaurus:Patella"} @@ -241795,8 +347468,14 @@ xref: Wikipedia:Patella is_a: UBERON:0001479 {source="FMA"} ! sesamoid bone is_a: UBERON:0005893 ! leg bone is_a: UBERON:0011141 ! appendicular ossicle +intersection_of: UBERON:0001474 ! bone element +intersection_of: connected_to UBERON:0000981 ! femur +intersection_of: part_of UBERON:0001465 ! knee +relationship: adjacent_to UBERON:0001485 ! knee joint +relationship: connected_to UBERON:0000981 ! femur relationship: part_of UBERON:0001465 ! knee -property_value: depicted:by Knee:diagram.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "patellar" xsd:string [Term] @@ -241853,6 +347532,7 @@ id: UBERON:0002450 name: decidua namespace: uberon def: "The maternal uterine-derived portion of the placenta." [MP:0004256, PMID:11433360] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "decidous membrane" EXACT [FMA:85538] @@ -241884,6 +347564,7 @@ relationship: develops_from UBERON:0000459 ! uterine wall relationship: part_of UBERON:0001987 {component="maternal", source="MA"} ! placenta property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray33.png xsd:anyURI property_value: editor_note "TODO - check mp syn" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000011 "formed under the influence of progesterone and forms highly-characteristic cells. [Wikipedia:Decidua]" xsd:string [Term] @@ -241891,6 +347572,7 @@ id: UBERON:0002451 name: endometrial gland namespace: uberon def: "The mucous secreting gland associated with the mucuous membrane lining the uterus." [Wikipedia:Uterine_glands] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim subset: uberon_slim @@ -241912,8 +347594,12 @@ is_a: UBERON:0000414 {source="MP"} ! mucous gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0005398 ! female reproductive gland +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0001295 ! endometrium +relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular relationship: part_of UBERON:0012276 ! endometrium glandular epithelium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/28/Gray1169.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "simple or branched tubular" xsd:string property_value: UBPROP:0000202 FMA:71647 @@ -241937,7 +347623,15 @@ xref: SCTID:181206009 xref: UMLS:C0015028 {source="ncithesaurus:Ethmoid_Sinus"} xref: Wikipedia:Ethmoid_bone_sinus is_a: UBERON:0001825 {source="FMA"} ! paranasal sinus -property_value: depicted:by Nnh:front.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg xsd:anyURI + +[Term] +id: UBERON:0002456 +name: internal thoracic artery +is_a: UBERON:0004573 ! systemic artery +relationship: branching_part_of UBERON:0001533 ! subclavian artery +relationship: part_of UBERON:0001533 ! subclavian artery +relationship: supplies UBERON:0000310 ! breast [Term] id: UBERON:0002457 @@ -241986,6 +347680,14 @@ intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0002240 ! spinal cord relationship: supplies UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0002459 +name: inferior palpebral vein +is_a: UBERON:0014769 ! palpebral vein +intersection_of: UBERON:0014769 ! palpebral vein +intersection_of: drains UBERON:0001713 ! lower eyelid +relationship: drains UBERON:0001713 ! lower eyelid + [Term] id: UBERON:0002460 name: vesical vein @@ -242136,11 +347838,13 @@ property_value: UBPROP:0000012 "We follow FMA and MA in distinguishing between l id: UBERON:0002466 name: intestine secretion namespace: uberon +def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [Wikipedia:Succus_entericus] def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [http://en.wikipedia.org/wiki/Succus_entericus] subset: pheno_slim subset: uberon_slim synonym: "intestinal juice" RELATED [BTO:0000644] synonym: "intestinal secretion" EXACT [FMA:62974] +synonym: "succus entericus" EXACT [Wikipedia:Succus_entericus] synonym: "succus entericus" EXACT [http://en.wikipedia.org/wiki/Succus_entericus] xref: BTO:0000644 xref: FMA:62974 @@ -242151,6 +347855,7 @@ xref: MESH:D007419 xref: NCIT:C32875 xref: Succus:entericus xref: UMLS:C0021849 {source="ncithesaurus:Intestinal_Secretion"} +xref: Wikipedia:Succus_entericus is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: produced_by UBERON:0000160 ! intestine @@ -242233,6 +347938,7 @@ xref: BTO:0002859 xref: EMAPA:26981 xref: FMA:62996 xref: MA:0002680 +xref: MESH:D000071041 xref: NCIT:C32538 xref: SCTID:362127004 xref: UMLS:C0227176 {source="ncithesaurus:Esophageal_Mucosa"} @@ -242273,8 +347979,14 @@ xref: MIAA:0000091 xref: NCIT:C77660 xref: SCTID:95936004 xref: UMLS:C0687080 {source="ncithesaurus:Paw"} +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: has_skeleton UBERON:0006717 ! autopodial skeleton +relationship: contributes_to_morphology_of UBERON:0002101 ! limb relationship: develops_from UBERON:0010130 {evidence="definitional"} ! embryonic autopod plate +relationship: distally_connected_to UBERON:0002471 ! zeugopod +relationship: has_skeleton UBERON:0006717 ! autopodial skeleton property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group; note that this refers to the limb segment, not just the skeleton." xsd:string [Term] @@ -242301,7 +348013,13 @@ xref: FMA:83016 xref: MA:0002716 xref: MAT:0000092 xref: MIAA:0000092 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: has_skeleton UBERON:0011584 ! zeugopodial skeleton +relationship: distal_to UBERON:0002472 ! stylopod +relationship: has_skeleton UBERON:0011584 ! zeugopodial skeleton +relationship: proximal_to UBERON:0002470 ! autopod region property_value: UBPROP:0000007 "zeugopodial" xsd:string [Term] @@ -242322,7 +348040,12 @@ xref: FMA:83014 xref: MA:0002717 xref: MAT:0000093 xref: MIAA:0000093 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: has_skeleton UBERON:0011583 ! stylopodial skeleton +relationship: has_skeleton UBERON:0011583 ! stylopodial skeleton +relationship: proximal_to UBERON:0002471 ! zeugopod property_value: RO:0002171 UBERON:0002470 property_value: RO:0002171 UBERON:0002471 property_value: UBPROP:0000007 "stylopodial" xsd:string @@ -242338,10 +348061,15 @@ synonym: "inter-hemispheric commissure" RELATED [] synonym: "interhemispheric commissure" RELATED [MA:0002721] xref: EMAPA:35435 xref: FMA:67930 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1559 xref: MA:0002721 +xref: neuronames:1559 xref: SCTID:360567002 is_a: UBERON:0019294 ! commissure of telencephalon +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: connects UBERON:0002812 ! left cerebral hemisphere +intersection_of: connects UBERON:0002813 ! right cerebral hemisphere +relationship: connects UBERON:0002812 ! left cerebral hemisphere +relationship: connects UBERON:0002813 ! right cerebral hemisphere relationship: part_of UBERON:0002437 ! cerebral hemisphere white matter [Term] @@ -242362,8 +348090,8 @@ synonym: "set of cerebellar peduncles" RELATED [FMA:77791] xref: BAMS:cbp xref: BIRNLEX:970 xref: FMA:77791 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 {source="BIRNLEX:970"} xref: MBA:752 +xref: neuronames:224 {source="BIRNLEX:970"} xref: UMLS:C0228514 {source="BIRNLEX:970"} xref: Wikipedia:Cerebellar_peduncle is_a: UBERON:0002616 ! regional part of brain @@ -242402,8 +348130,12 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011164 ! neurocranium bone is_a: UBERON:0015059 ! orbitosphenoid endochondral element is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: contributes_to_morphology_of UBERON:0001677 ! sphenoid bone relationship: develops_from UBERON:0005687 ! orbitosphenoid cartilage element relationship: develops_from UBERON:0009638 ! orbitosphenoid ossification center +relationship: in_lateral_side_of UBERON:0002517 ! basicranium relationship: part_of UBERON:0001677 ! sphenoid bone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png xsd:anyURI property_value: UBPROP:0000001 "Endochondral ossification of the lateral sides of the braincase.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000345", ontology="AAO", source="AAO:LAP"} @@ -242445,7 +348177,7 @@ xref: XAO:0004040 xref: ZFA:0005621 is_a: UBERON:0004755 {source="VSAO"} ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001474 ! bone element property_value: editor_note "see https://github.com/obophenotype/uberon/issues/27" xsd:string property_value: UBPROP:0000001 "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000047", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} @@ -242469,6 +348201,7 @@ name: trabecular bone tissue namespace: uberon def: "Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow." [ISBN:0-683-40008-8, MGI:csmith, MP:0000130] comment: one of the two types of osseous tissue that form bones. Compared to compact bone, which is the other type of osseous tissue, it has a higher surface area but is less dense, softer, weaker, and less stiff. It typically occurs at the ends of long bones, proximal to joints and within the interior of vertebrae. Cancellous bone is highly vascular and frequently contains red bone marrow where hematopoiesis, which is the production of blood cells, occurs. The primary anatomical and functional unit of cancellous bone is the trabecula. +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cancellated bone" RELATED [BTO:0001700] @@ -242491,6 +348224,7 @@ xref: Wikipedia:Trabecular_bone is_a: UBERON:0002481 ! bone tissue relationship: part_of UBERON:0002482 ! lamellar bone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/34/Illu_compact_spongy_bone.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002484 @@ -242532,6 +348266,9 @@ xref: UMLS:C0227965 {source="ncithesaurus:Prostatic_Duct"} xref: Wikipedia:Prostatic_ducts is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005904 ! duct of male reproductive system +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: contributes_to_morphology_of UBERON:0002367 ! prostate gland relationship: develops_from UBERON:0003820 {source="PMID:18977204"} ! prostate bud relationship: part_of UBERON:0002367 ! prostate gland @@ -242554,8 +348291,9 @@ xref: UMLS:C0017681 {source="ncithesaurus:Glottis"} xref: Wikipedia:Glottis is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000477 ! anatomical cluster +relationship: contributes_to_morphology_of UBERON:0001737 ! larynx relationship: part_of UBERON:0001737 ! larynx -property_value: depicted:by Arytenoid:cartilage.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/32/Arytenoid_cartilage.png xsd:anyURI property_value: UBPROP:0000001 "A small, slit-like aperture lying longitudinally on the floor of the pharynx.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010610", ontology="AAO", source="AAO:BMZ"} [Term] @@ -242574,7 +348312,7 @@ synonym: "pulp cavity of tooth" EXACT [] synonym: "tooth pulp cavity" RELATED [MA:0002792] xref: FMA:55660 xref: MA:0002792 -xref: MESH:A14.254.900.265 +xref: MESH:D003786 xref: SCTID:362105008 xref: Wikipedia:Tooth_cavity is_a: CARO:0000000 ! anatomical entity @@ -242623,10 +348361,9 @@ xref: MA:0002795 xref: OpenCyc:Mx4rv2eGHZwpEbGdrcN5Y29ycA xref: SCTID:244510008 xref: Wikipedia:Coronal_suture -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003685 ! cranial suture relationship: part_of UBERON:0004339 ! vault of skull -property_value: depicted:by Gray188-Coronal:suture.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/ae/Gray188-Coronal_suture.png xsd:anyURI [Term] id: UBERON:0002490 @@ -242648,8 +348385,8 @@ xref: MA:0002796 xref: SCTID:136854008 xref: Wikipedia:Frontal_suture is_a: UBERON:0003685 ! cranial suture -property_value: depicted:by Frontal:suture.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png xsd:anyURI property_value: UBPROP:0000008 "in humans, the frontal suture is a dense connective tissue structure that divides the two halves of the frontal bone of the skull in infants and children. It usually disappears by the age of six, with the two halves of the frontal bone being fused together. If it does not disappear it may be called a 'metopic suture' or 'sutura frontalis persistens. ' If the suture is not present at birth (craniosynostosis) it will cause a keel-shaped deformity of the skull called 'trigonocephaly. ' It is present in a fetal skull so that the skull can bend and is very elastic at the time of birth. The baby's head literally bends when coming out of the mother's womb. The space is filled as the child grows older. [WP,unvetted]" xsd:string [Term] @@ -242667,10 +348404,9 @@ xref: FMA:52933 xref: MA:0002797 xref: SCTID:361830007 xref: Wikipedia:Lambdoid_suture -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003685 ! cranial suture relationship: part_of UBERON:0004339 {source="HP"} ! vault of skull -property_value: depicted:by Gray188-Lambdoid:suture.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/3d/Gray188-Lambdoid_suture.png xsd:anyURI [Term] id: UBERON:0002492 @@ -242686,7 +348422,6 @@ xref: FMA:52929 xref: MA:0002798 xref: SCTID:244511007 xref: Wikipedia:Sagittal_suture -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003685 ! cranial suture relationship: part_of UBERON:0004339 ! vault of skull property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/24/Kort-lang-skalle.gif xsd:anyURI @@ -242696,11 +348431,13 @@ id: UBERON:0002493 name: uterine artery namespace: uberon def: "The branch of the internal iliac artery that supplies the uterus and the upper part of the vagina." [MGI:monikat, MP:0003995] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "arteria uterina" RELATED LATIN [Wikipedia:Uterine_artery] xref: FMA:18829 xref: MA:0002799 +xref: MESH:D055988 xref: SCTID:244300003 xref: Wikipedia:Uterine_artery is_a: UBERON:0001190 ! ovarian artery @@ -242708,6 +348445,7 @@ is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0010192 ! genital artery is_a: UBERON:0015212 ! lateral structure property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002494 @@ -242736,7 +348474,7 @@ xref: Wikipedia:Papillary_muscle is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002082 ! cardiac ventricle -property_value: depicted:by Papillary:muscles.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/87/Papillary_muscles.png xsd:anyURI property_value: UBPROP:0000003 "On the internal or parietal surface of the left ventricle in man and in mammals are two papillary muscles, which are almost identical and well developed.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001392", ontology="VHOG", source="DOI:10.1111/j.1368-5031.2005.00345.x", source="http://bgee.unil.ch/"} property_value: UBPROP:0000009 "These muscles contract to tighten the chordae tendineae, which in turn prevent inversion. This occurs in response to pressure gradients. Instead they brace the valves against the high pressure, preventing regurgitation of ventricular blood back into the atrial cavities.[Wikipedia:Papillary_muscle]" xsd:string @@ -242760,6 +348498,7 @@ xref: SCTID:332709000 xref: UMLS:C0222647 {source="ncithesaurus:Long_Bone"} xref: Wikipedia:Long_bone is_a: UBERON:0001474 ! bone element +relationship: contributes_to_morphology_of UBERON:0002091 ! appendicular skeleton relationship: part_of UBERON:0002091 ! appendicular skeleton [Term] @@ -242805,7 +348544,6 @@ xref: SCTID:181911000 xref: UMLS:C0001209 {source="ncithesaurus:Acromion"} xref: VSAO:0005067 xref: Wikipedia:Acromion -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004530 ! bony projection relationship: part_of UBERON:0006849 ! scapula property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/79/Gray206.png xsd:anyURI @@ -242839,6 +348577,7 @@ xref: Wikipedia:Deltoid_tuberosity is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005813 ! tubercle is_a: UBERON:4100000 ! skeletal element projection +relationship: contributes_to_morphology_of UBERON:0000976 ! humerus relationship: part_of UBERON:0004652 ! humerus diaphysis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a7/HumerusFront.png xsd:anyURI property_value: UBPROP:0000008 "In basal Tetrapodomorph lineages often the deltoid process and the pectoral processes are separate and thus should not be made exact synonyms to the deltopectoral crest.[PHENOSCAPE:ad]" xsd:string @@ -242887,7 +348626,7 @@ xref: Wikipedia:Zygomatic_arch is_a: UBERON:0003462 ! facial bone is_a: UBERON:0011164 {source="MA"} ! neurocranium bone is_a: UBERON:0015212 ! lateral structure -property_value: depicted:by Gray188-Sphenozygomatic:suture.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/f4/Gray188-Sphenozygomatic_suture.png xsd:anyURI property_value: UBPROP:0000008 "The zygomatic arch is significant in evolutionary biology, as it is part of the structures derived from the ancestral single temporal fenestra of the synapsid ancestor of mammals." xsd:string property_value: UBPROP:0000010 "The zygomatic process of the temporal arises by two roots: an anterior, directed inward in front of the mandibular fossa, where it expands to form the articular tubercle. a posterior, which runs backward above the external acoustic meatus and is continuous with the supramastoid crest. The upper border of the arch gives attachment to the temporal fascia; the lower border and medial surface give origin to the Masseter" xsd:string property_value: UBPROP:0000013 "The zygomatic arch is occasionally referred to as the zygoma, but this term usually refers to the zygomatic bone or occasionally the zygomatic process." xsd:string @@ -242969,6 +348708,7 @@ id: UBERON:0002505 name: spiral modiolar artery namespace: uberon def: "The artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents." [MP:0004629] +subset: human_reference_atlas subset: pheno_slim xref: FMA:52312 xref: MA:0002824 @@ -242978,12 +348718,14 @@ is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001846 ! internal ear +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002506 name: iris epithelium namespace: uberon def: "An epithelium that is part of a iris [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of iris" EXACT [OBOL:automatic] synonym: "epithelium of iris" EXACT [OBOL:automatic] @@ -243003,6 +348745,7 @@ intersection_of: part_of UBERON:0001769 ! iris relationship: contributes_to_morphology_of UBERON:0001769 ! iris relationship: has_part GO:0048770 {source="MP"} ! pigment granule relationship: part_of UBERON:0001769 {source="MA"} ! iris +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002507 @@ -243019,12 +348762,15 @@ xref: MA:0002827 xref: SCTID:245342005 is_a: UBERON:0000029 ! lymph node is_a: UBERON:0005172 ! abdomen element +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0002508 name: celiac lymph node namespace: uberon def: "The visceral glands that are associated with the branches of the celiac artery, including the gastric, hepatic, and pancreaticolienal (splenic) lymph nodes." [MGI:csmith, MP:0009626] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "aJCC level 20 node" RELATED [FMA:12792] @@ -243044,12 +348790,14 @@ xref: UMLS:C0229766 {source="ncithesaurus:Celiac_Lymph_Node"} xref: Wikipedia:Celiac_lymph_node is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/71/Gray613.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002509 name: mesenteric lymph node namespace: uberon def: "The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group." [MP:0005232] +subset: human_reference_atlas subset: pheno_slim synonym: "mesenteric node" EXACT [] synonym: "nodi lymphoidei mesenterici" RELATED LATIN [BTO:0000767] @@ -243062,7 +348810,10 @@ xref: UMLS:C0229792 {source="ncithesaurus:Mesenteric_Lymph_Node"} xref: Wikipedia:Mesenteric_lymph_nodes is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0015860 {source="FMA"} ! visceral abdominal lymph node +intersection_of: UBERON:0002507 ! abdominal lymph node +intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002510 @@ -243113,6 +348864,7 @@ id: UBERON:0002512 name: corpus luteum namespace: uberon def: "A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]." [PMID:20959416, Wikipedia:Corpus_luteum] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corpora lutea" EXACT PLURAL [] @@ -243133,10 +348885,14 @@ xref: Wikipedia:Corpus_luteum is_a: UBERON:0002368 {source="PMID:20959416"} ! endocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005398 ! female reproductive gland +relationship: capable_of GO:0042701 ! progesterone secretion relationship: develops_from UBERON:0001305 ! ovarian follicle +relationship: has_part CL:0000175 ! luteal cell +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000992 {source="MA"} ! ovary property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/57/Folliclesinovary.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:7762 {source="PMID:20959416"} +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "maintains the endometrium in mammals[WP]. A corpus luteum is known in hagfish (100), Squalus (101), and salamander (100) but not lamprey (102). There are no data for Branchiostoma and Ciona, and given that they are multiple spawners, there is no a priori reason to conclude that they lack a corpus luteum" xsd:string {source="PMID:20959416"} [Term] @@ -243209,8 +348965,9 @@ xref: SCTID:33840008 xref: UMLS:C0031110 {source="ncithesaurus:Periosteum"} xref: Wikipedia:Periosteum is_a: UBERON:0000158 ! membranous layer +relationship: composed_primarily_of UBERON:0011822 ! dense irregular connective tissue relationship: part_of UBERON:0001474 ! bone element -property_value: depicted:by Bone:growth.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png xsd:anyURI property_value: UBPROP:0000007 "periosteal" xsd:string [Term] @@ -243266,6 +349023,7 @@ xref: UMLS:C0149543 {source="ncithesaurus:Base_of_the_Skull"} xref: Wikipedia:Base_of_skull is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: contributes_to_morphology_of UBERON:0003128 ! cranium relationship: part_of UBERON:0001703 ! neurocranium relationship: part_of UBERON:0002241 ! chondrocranium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png xsd:anyURI @@ -243360,7 +349118,6 @@ xref: MESH:D004547 xref: NCIT:C32495 xref: SCTID:27197004 xref: Wikipedia:Elastic_fiber -is_a: BFO:0000040 ! material entity is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: composed_primarily_of GO:0071953 ! elastic fiber @@ -243392,11 +349149,11 @@ xref: SCTID:61695000 xref: Tunica:media xref: UMLS:C0162867 {source="ncithesaurus:Tunica_Media"} xref: Wikipedia:Tunica_media -is_a: BFO:0000040 ! material entity is_a: UBERON:0004797 {source="MA"} ! blood vessel layer relationship: has_part UBERON:0002521 {source="cjm"} ! elastic tissue relationship: has_part UBERON:0004237 {source="cjm"} ! blood vessel smooth muscle relationship: surrounded_by UBERON:0005734 ! tunica adventitia of blood vessel +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg xsd:anyURI property_value: depicted:by Illu:artery.jpg xsd:anyURI [Term] @@ -243429,6 +349186,7 @@ is_a: UBERON:0004923 {source="FMA"} ! organ component layer relationship: adjacent_to UBERON:0010161 {source="ISBN:0073040584"} ! lumen of blood vessel relationship: has_part UBERON:0001986 ! endothelium relationship: surrounded_by UBERON:0002522 {notes="check for exceptions, e.g. capillaries"} ! tunica media +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg xsd:anyURI property_value: depicted:by Illu:artery.jpg xsd:anyURI property_value: editor_note "the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure" xsd:string property_value: editor_note "the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts" xsd:string @@ -243450,6 +349208,23 @@ xref: Wikipedia:Brachial_lymph_nodes is_a: UBERON:0000029 ! lymph node property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/73/Gray607.png xsd:anyURI +[Term] +id: UBERON:0002527 +name: pancreatic lymph node +is_a: UBERON:0002507 ! abdominal lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas + +[Term] +id: UBERON:0002528 +name: sacral lymph node +is_a: UBERON:0000029 ! lymph node +is_a: UBERON:0005179 ! pelvic region element +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0005473 ! sacral region +relationship: part_of UBERON:0005473 ! sacral region + [Term] id: UBERON:0002529 name: limb segment @@ -243466,6 +349241,12 @@ xref: MA:0002889 xref: NCIT:C38630 xref: UMLS:C1268195 {source="ncithesaurus:Extremity_Part"} is_a: UBERON:0010538 ! paired limb/fin segment +intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis +intersection_of: part_of UBERON:0002101 ! limb +disjoint_from: UBERON:0010912 ! subdivision of skeleton +relationship: existence_ends_during UBERON:0000066 ! fully formed stage +relationship: existence_starts_during UBERON:0000068 ! embryo stage +relationship: has_part UBERON:0014892 ! skeletal muscle organ relationship: part_of UBERON:0002101 ! limb property_value: editor_note "TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition" xsd:string property_value: UBPROP:0000012 "FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z" xsd:string {external_ontology="FMA"} @@ -243592,6 +349373,8 @@ xref: VHOG:0000201 xref: XAO:0000107 xref: ZFA:0000077 is_a: UBERON:0006598 ! presumptive structure +relationship: has_potential_to_develop_into UBERON:0007812 ! post-anal tail +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: editor_note "See notes from https://github.com/obophenotype/uberon/wiki/The-neural-crest" xsd:string property_value: UBPROP:0000001 "Rapidly proliferating mass of cells at the caudal extremity of the embryo. Its formation is reflected in a caudal carving of the posterior portion of the archenteric canal at NF stage 22. With its further outgrowth, the postanal gut primordium becomes stretched. Its lumen is in broad communication with the hindgut at NF stage 25.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011104", ontology="AAO", source="ISBN:0815318960", source="OMD:tail+bud"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (5) a larva or embryo with a postanal tail.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000201", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} @@ -243633,6 +349416,17 @@ relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda relationship: part_of UBERON:0001016 ! nervous system property_value: editor_note "this term should be ceded to the arthropod anatomy ontology" xsd:string +[Term] +id: UBERON:0002537 +name: hermaphrodite gonad +is_a: UBERON:0000991 ! gonad +intersection_of: UBERON:0000991 ! gonad +intersection_of: capable_of GO:0007283 ! spermatogenesis +intersection_of: capable_of GO:0048477 ! oogenesis +relationship: capable_of GO:0007283 ! spermatogenesis +relationship: capable_of GO:0048477 ! oogenesis +relationship: part_of UBERON:0007197 ! hermaphroditic organism + [Term] id: UBERON:0002539 name: pharyngeal arch @@ -243659,6 +349453,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0080322 xref: http://www.snomedbrowser.com/Codes/Details/308766004 xref: MAT:0000242 xref: MESH:A16.254.160 +xref: MESH:D001934 xref: MIAA:0000242 xref: NCIT:C34249 xref: Pharyngeal:arch @@ -243669,6 +349464,7 @@ xref: VHOG:0000155 xref: Wikipedia:Pharyngeal_arch xref: XAO:0000096 xref: ZFA:0001306 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -243731,6 +349527,11 @@ xref: VHOG:0000944 xref: Wikipedia:Digit_(anatomy) xref: XAO:0003032 is_a: UBERON:0005881 ! autopodial extension +intersection_of: UBERON:0005881 ! autopodial extension +intersection_of: part_of UBERON:0012354 ! acropodium region +relationship: contributes_to_morphology_of UBERON:0002470 ! autopod region +relationship: has_part UBERON:0015023 ! phalanx endochondral element +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda relationship: part_of UBERON:0012354 ! acropodium region relationship: part_of UBERON:5002544 ! digit plus metapodial segment property_value: IAO:0000232 "this class represents the entire organism subdivision encompassing soft tissue as well as the underlying skeletal framework. The class represents the phalangeal part only - historically the term 'digit' has also been used to represent the unit consisting of a series of phalanges together with a metapodial bone. We may in future relabel this class to avoid confusion with this concept, but the class will continue to represent the phalangeal portion" xsd:string @@ -243790,6 +349591,7 @@ xref: AEO:0000126 xref: BTO:0000707 xref: FBbt:00001727 xref: HAO:0000459 +xref: MESH:D007814 xref: OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA xref: TAO:0002048 xref: Wikipedia:Larva @@ -243812,9 +349614,9 @@ xref: DHBA:266441551 xref: FMA:62027 xref: HBA:12902 xref: HBA:4570 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2381 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=376 {source="BIRNLEX:1005"} -xref: MESH:A08.186.211.730.385.357.342 +xref: MESH:D007032 +xref: neuronames:2381 +xref: neuronames:376 {source="BIRNLEX:1005"} xref: UMLS:C0020653 {source="BIRNLEX:1005"} is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0001898 ! hypothalamus @@ -243896,8 +349698,8 @@ xref: DMBA:16589 xref: EMAPA:37921 {source="MA:th"} xref: FMA:72405 xref: HBA:9086 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472 {source="BIRNLEX:1037"} xref: MBA:706 +xref: neuronames:472 {source="BIRNLEX:1037"} xref: UMLS:C0175359 {source="BIRNLEX:1037"} xref: Wikipedia:Olivary_pretectal_nucleus is_a: UBERON:0011214 {source="FMA"} ! nucleus of midbrain tectum @@ -243932,7 +349734,7 @@ xref: BIRNLEX:1043 xref: DHBA:12405 xref: FMA:72244 xref: HBA:9132 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=616 {source="BIRNLEX:1043"} +xref: neuronames:616 {source="BIRNLEX:1043"} xref: SCTID:361541001 xref: UMLS:C0228427 {source="BIRNLEX:1043"} xref: Wikipedia:Basilar_part_of_pons @@ -243946,6 +349748,7 @@ name: postcentral gyrus namespace: uberon def: "Component of the parietal lobe. The appearance and disappearance of the central sulcus were the rostral and caudal boundaries of the postcentral gyrus respectively. The medial and lateral boundaries were the lateral bank of the precentral gyrus and the lateral fissure and/or the medial bank of the superior parietal gyrus respectively (Christine Fennema-Notestine)." [BIRNLEX:1070] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "gyrus centralis posterior" RELATED LATIN [NeuroNames:105] @@ -243962,15 +349765,16 @@ xref: DHBA:12132 xref: EFO:0001383 xref: FMA:61896 xref: HBA:4085 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=105 {source="BIRNLEX:1070"} xref: NCIT:C33346 +xref: neuronames:105 {source="BIRNLEX:1070"} xref: SCTID:279167001 xref: UMLS:C0152302 {source="ncithesaurus:Postcentral_Gyrus"} xref: UMLS:C0152302 {source="BIRNLEX:1070"} xref: Wikipedia:Postcentral_gyrus is_a: UBERON:0000200 ! gyrus relationship: part_of UBERON:0001872 ! parietal lobe -property_value: depicted:by Postcentral:gyrus.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/66/Postcentral_gyrus.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002589 @@ -243996,9 +349800,9 @@ xref: BIRNLEX:1095 xref: DHBA:12759 xref: EMAPA:37888 {source="MA:th"} xref: FMA:72635 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=801 {source="BIRNLEX:1095"} xref: MBA:1019 xref: NCIT:C32406 +xref: neuronames:801 {source="BIRNLEX:1095"} xref: SCTID:369091005 xref: UMLS:C0152402 {source="BIRNLEX:1095"} xref: Wikipedia:Lateral_corticospinal_tract @@ -244012,6 +349816,7 @@ id: UBERON:0002600 name: limbic lobe namespace: uberon def: "Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem." [BIRNLEX:1128] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "fornicate convolution" RELATED [NeuroNames:834] @@ -244028,12 +349833,14 @@ xref: CALOHA:TS-2061 xref: DHBA:12155 xref: FMA:72719 xref: HBA:4219 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=834 {source="BIRNLEX:1128"} +xref: MESH:D065726 +xref: neuronames:834 {source="BIRNLEX:1128"} xref: SCTID:279215006 xref: UMLS:C0458337 {source="BIRNLEX:1128"} xref: Wikipedia:Limbic_lobe is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7e/Human_brain_inferior-medial_view_description.JPG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002602 @@ -244063,7 +349870,7 @@ xref: DMBA:16930 xref: EMAPA:37821 {source="MA:th"} xref: FMA:72538 xref: HBA:12947 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=688 {source="BIRNLEX:1135"} +xref: neuronames:688 {source="BIRNLEX:1135"} xref: SCTID:279222003 xref: UMLS:C0175488 {source="BIRNLEX:1135"} xref: Wikipedia:Emboliform_nucleus @@ -244107,8 +349914,8 @@ xref: DHBA:12437 xref: EV:0100260 xref: FMA:72240 xref: HBA:9528 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=720 {source="BIRNLEX:1151"} xref: MBA:607 +xref: neuronames:720 {source="BIRNLEX:1151"} xref: UMLS:C0152411 {source="BIRNLEX:1151"} xref: UMLS:C0152411 {source="ncithesaurus:Cochlear_Nuclei"} xref: Wikipedia:Cochlear_nuclei @@ -244151,7 +349958,7 @@ xref: DMBA:16932 xref: EMAPA:37820 {source="MA:th"} xref: FMA:72536 xref: HBA:12949 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=689 {source="BIRNLEX:1158"} +xref: neuronames:689 {source="BIRNLEX:1158"} xref: SCTID:279223008 xref: UMLS:C0175489 {source="BIRNLEX:1158"} xref: Wikipedia:Globose_nucleus @@ -244183,7 +349990,6 @@ xref: http://www.snomedbrowser.com/Codes/Details/384763002 xref: NCIT:C13031 xref: SCTID:384763002 xref: UMLS:C0445620 {source="ncithesaurus:Brain_Part"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure @@ -244224,10 +350030,10 @@ xref: EMAPA:35882 xref: EV:0100273 xref: FMA:54562 xref: HBA:9206 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=559 {source="BIRNLEX:1222"} xref: MA:0001029 xref: MBA:621 xref: NCIT:C33140 +xref: neuronames:559 {source="BIRNLEX:1222"} xref: SCTID:38390003 xref: TAO:0001365 xref: UMLS:C0228700 {source="ncithesaurus:Motor_Nucleus_of_the_Trigeminal_Nerve"} @@ -244281,9 +350087,9 @@ xref: EV:0100231 xref: FMA:62319 xref: GAID:642 xref: HBA:12903 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=386 {source="BIRNLEX:1226"} xref: MBA:88 -xref: MESH:A08.186.211.730.385.357.342.063 +xref: MESH:D007025 +xref: neuronames:386 {source="BIRNLEX:1226"} xref: SCTID:369133009 xref: UMLS:C0020653 {source="BIRNLEX:1226"} xref: Wikipedia:Anterior_hypothalamic_nucleus @@ -244312,9 +350118,9 @@ xref: EMAPA:35763 xref: FMA:61845 xref: GAID:637 xref: HBA:13002 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=259 xref: MA:0002978 -xref: MESH:A08.186.211.577.750.800 +xref: MESH:D012686 +xref: neuronames:259 xref: UMLS:C0036687 {source="BIRNLEX:1313"} xref: Wikipedia:Septal_nuclei is_a: UBERON:0005401 ! cerebral hemisphere gray matter @@ -244345,14 +350151,30 @@ xref: DHBA:10352 xref: EMAPA:35486 xref: FMA:61878 xref: HBA:4303 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=261 {source="BIRNLEX:1321"} xref: MBA:242 +xref: neuronames:261 {source="BIRNLEX:1321"} xref: UMLS:C0175232 {source="BIRNLEX:1321"} is_a: UBERON:0009663 ! telencephalic nucleus relationship: part_of UBERON:0007628 ! lateral septal complex property_value: RO:0002171 UBERON:0001878 {source="ABA"} property_value: RO:0002171 UBERON:0007630 {source="ABA"} +[Term] +id: UBERON:0002673 +name: vestibular nuclear complex +is_a: UBERON:0007245 ! nuclear complex of neuraxis +is_a: UBERON:0019263 ! gray matter of hindbrain +relationship: part_of UBERON:0001896 ! medulla oblongata +relationship: part_of UBERON:0004681 ! vestibular system + +[Term] +id: UBERON:0002682 +name: abducens nucleus +is_a: UBERON:0000126 ! cranial nerve nucleus +is_a: UBERON:0006331 ! brainstem nucleus +is_a: UBERON:0009662 ! hindbrain nucleus +relationship: part_of UBERON:0000988 ! pons + [Term] id: UBERON:0002688 name: supramarginal gyrus @@ -244370,8 +350192,8 @@ xref: BIRNLEX:1381 xref: DHBA:12135 xref: FMA:61897 xref: HBA:4104 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=108 {source="BIRNLEX:1381"} xref: NCIT:C33706 +xref: neuronames:108 {source="BIRNLEX:1381"} xref: SCTID:279185008 xref: UMLS:C0228214 {source="ncithesaurus:Supramarginal_Gyrus"} xref: UMLS:C0228214 {source="BIRNLEX:1381"} @@ -244386,6 +350208,7 @@ name: precentral gyrus namespace: uberon def: "Component of the frontal lobe. The appearance and disappearance of the central sulcus is the rostral and caudal boundaries of the precentral gyrus respectively. The medial boundary is specific frontal gyri (superior, middle and inferior) whereas the lateral boundary is the medial bank of the central sulcus (Christine Fennema-Notestine)." [BIRNLEX:1455] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "anterior central gyrus" RELATED [NeuroNames:89] @@ -244400,13 +350223,14 @@ xref: DHBA:12114 xref: EFO:0001373 xref: FMA:61894 xref: HBA:4010 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=89 {source="BIRNLEX:1455"} xref: NCIT:C33393 +xref: neuronames:89 {source="BIRNLEX:1455"} xref: UMLS:C0152299 {source="BIRNLEX:1455"} xref: UMLS:C0152299 {source="ncithesaurus:Precentral_Gyrus"} xref: Wikipedia:Precentral_gyrus is_a: UBERON:0015593 ! frontal gyrus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002704 @@ -244429,9 +350253,9 @@ xref: BIRNLEX:1461 xref: EMAPA:35376 xref: EV:0100217 xref: FMA:62023 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=351 {source="BIRNLEX:1461"} xref: MA:0000868 xref: MBA:1008 +xref: neuronames:351 {source="BIRNLEX:1461"} xref: SCTID:361550004 xref: Wikipedia:Metathalamus is_a: UBERON:0015233 ! nucleus of dorsal thalamus @@ -244467,9 +350291,9 @@ xref: BIRNLEX:1462 xref: BTO:0002454 xref: EMAPA:35573 xref: FMA:62020 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=306 {source="BIRNLEX:1462"} xref: MA:0000864 xref: MBA:571 +xref: neuronames:306 {source="BIRNLEX:1462"} xref: SCTID:279163002 xref: Wikipedia:Midline_nuclear_group is_a: UBERON:0015233 ! nucleus of dorsal thalamus @@ -244481,6 +350305,7 @@ name: corticospinal tract namespace: uberon alt_id: UBERON:0004095 def: "The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract." [ISBN:0-683-40008-8, MP:0002878] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "corticospinal fibers" EXACT [NeuroNames:1320] @@ -244488,7 +350313,7 @@ synonym: "fasciculus cerebro-spinalis" EXACT LATIN [NeuroNames:1320] synonym: "fasciculus pyramidalis" EXACT LATIN [NeuroNames:800] synonym: "fibrae corticospinales" EXACT LATIN [NeuroNames:1320] synonym: "pyramid (Willis)" EXACT [NeuroNames:800] -synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320, MP:0002878] +synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, MP:0002878, neuronames:1320] synonym: "tractus cortico-spinalis" EXACT LATIN [NeuroNames:1320] synonym: "tractus corticospinalis" EXACT LATIN [NeuroNames:1320] synonym: "tractus corticospinalis" EXACT LATIN [Wikipedia:Corticospinal_tract] @@ -244503,11 +350328,11 @@ xref: EMAPA:36600 xref: FMA:72634 xref: GAID:702 xref: HBA:265505574 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800 {source="BIRNLEX:1464"} xref: MBA:190 xref: MBA:784 xref: MESH:D011712 +xref: neuronames:1320 +xref: neuronames:800 {source="BIRNLEX:1464"} xref: SCTID:362325000 xref: UMLS:C0034229 {source="BIRNLEX:1464"} xref: Wikipedia:Corticospinal_tract @@ -244515,6 +350340,17 @@ is_a: UBERON:0001018 {notes="In NIFSTD this is a tract of brain but this leads t relationship: part_of UBERON:0025525 ! motor system relationship: part_of UBERON:0036224 ! corticobulbar and corticospinal tracts property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002722 +name: trochlear nucleus +is_a: UBERON:0000126 ! cranial nerve nucleus +is_a: UBERON:0006331 ! brainstem nucleus +is_a: UBERON:0007414 ! nucleus of midbrain tegmentum +is_a: UBERON:0009661 ! midbrain nucleus +relationship: extends_fibers_into UBERON:0001644 ! trochlear nerve +relationship: part_of UBERON:0001943 ! midbrain tegmentum [Term] id: UBERON:0002726 @@ -244528,9 +350364,9 @@ synonym: "pars cervicalis medullae spinalis" EXACT LATIN [FMA:71166, FMA:TA] synonym: "segmenta cervicalia medullae spinalis [1-8" EXACT LATIN [FMA:71166, FMA:TA] xref: BIRNLEX:1499 xref: FMA:71166 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1654 xref: MA:0003081 xref: NCIT:C12892 +xref: neuronames:1654 xref: SCTID:180960003 xref: UMLS:C0581619 {source="BIRNLEX:1499"} xref: UMLS:C0581619 {source="ncithesaurus:Cervical_Spinal_Cord"} @@ -244566,11 +350402,11 @@ xref: EFO:0001920 xref: EMAPA:35313 xref: FMA:72356 xref: GAID:636 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=168 {source="BIRNLEX:1508"} xref: MA:0003117 xref: MBA:909 -xref: MESH:A08.186.211.577.710.225 +xref: MESH:D018728 xref: NCIT:C97338 +xref: neuronames:168 {source="BIRNLEX:1508"} xref: PBA:294022158 xref: SCTID:369099007 xref: UMLS:C0175196 {source="BIRNLEX:1508"} @@ -244615,10 +350451,10 @@ xref: DHBA:10442 xref: EMAPA:35445 xref: FMA:62021 xref: GAID:660 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=317 {source="BIRNLEX:1530"} xref: MA:0000871 xref: MBA:51 -xref: MESH:A08.186.211.730.385.826.701.460 +xref: MESH:D020646 +xref: neuronames:317 {source="BIRNLEX:1530"} xref: SCTID:279159009 xref: Wikipedia:Intralaminar_thalamic_nuclei is_a: UBERON:0015233 ! nucleus of dorsal thalamus @@ -244632,6 +350468,7 @@ id: UBERON:0002743 name: basal forebrain namespace: uberon def: "A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert." [BIRNLEX:1560] +subset: human_reference_atlas subset: uberon_slim synonym: "basal forebrain area" RELATED [NeuroNames:1997] synonym: "pars basalis telencephali" RELATED LATIN [Wikipedia:Basal_forebrain] @@ -244643,12 +350480,14 @@ xref: DHBA:10349 xref: EMAPA:35164 xref: FMA:77700 xref: HBA:4300 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1997 {source="BIRNLEX:1560"} +xref: MESH:D066187 +xref: neuronames:1997 {source="BIRNLEX:1560"} xref: PBA:128012976 xref: Wikipedia:Basal_forebrain is_a: UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0001890 {source="BTO"} ! forebrain property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002749 @@ -244662,6 +350501,8 @@ xref: BIRNLEX:1571 xref: FMA:76924 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000481 ! multi-tissue structure +intersection_of: part_of UBERON:0002129 ! cerebellar cortex relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] @@ -244694,8 +350535,8 @@ xref: DMBA:17760 xref: EMAPA:37945 {source="MA:th"} xref: FMA:72633 xref: HBA:12965 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=799 {source="BIRNLEX:1594"} xref: MBA:198 +xref: neuronames:799 {source="BIRNLEX:1594"} xref: SCTID:369058001 xref: UMLS:C0011128 {source="BIRNLEX:1594"} xref: Wikipedia:Decussation_of_pyramids @@ -244733,8 +350574,8 @@ xref: BIRNLEX:1618 xref: DHBA:12798 xref: EMAPA:37889 {source="MA:th"} xref: FMA:72636 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=802 {source="BIRNLEX:1618"} xref: MBA:1028 +xref: neuronames:802 {source="BIRNLEX:1618"} xref: SCTID:369092003 xref: UMLS:C0152403 {source="BIRNLEX:1618"} xref: Wikipedia:Ventral_corticospinal_tract @@ -244748,6 +350589,7 @@ name: superior temporal gyrus namespace: uberon def: "Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the ssuperior temporal sulcus. The caudal boundary is the cauday portion of the superior temporal gyrus (posterior to becoming continuous with the supramarginal gyrus). The medial boundary is the lateral fissure (and when present the supramarginal gyrus), and the lateral boundary is the superior temporal suclus (Christine Fennema-Notestine)." [BIRNLEX:1648] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "gyrus temporalis superior" EXACT [BIRNLEX:1648] @@ -244759,15 +350601,16 @@ xref: DHBA:12140 xref: EFO:0001944 xref: FMA:61905 xref: HBA:4133 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=136 {source="BIRNLEX:1648"} xref: NCIT:C33698 xref: ncithesaurus:Superior_Temporal_Gyrus +xref: neuronames:136 {source="BIRNLEX:1648"} xref: SCTID:362345008 xref: UMLS:C0152309 {source="BIRNLEX:1648"} xref: Wikipedia:Superior_temporal_gyrus is_a: UBERON:0000200 ! gyrus relationship: part_of UBERON:0001871 ! temporal lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1d/Superior_temporal_gyrus.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002770 @@ -244786,8 +350629,8 @@ xref: BIRNLEX:1651 xref: FMA:62029 xref: GAID:651 xref: HBA:4665 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=411 {source="BIRNLEX:1651"} -xref: MESH:A08.186.211.730.385.357.362 +xref: MESH:D007034 +xref: neuronames:411 {source="BIRNLEX:1651"} xref: UMLS:C0020670 {source="BIRNLEX:1651"} xref: Wikipedia:Mammillary_process is_a: UBERON:0002616 ! regional part of brain @@ -244818,8 +350661,8 @@ xref: BTO:0002467 xref: DMBA:16423 xref: EV:0100206 xref: FMA:62022 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=333 {source="BIRNLEX:1669"} xref: MBA:637 +xref: neuronames:333 {source="BIRNLEX:1669"} xref: SCTID:279125005 xref: UMLS:C0228333 {source="BIRNLEX:1669"} xref: Wikipedia:Ventral_nuclear_group @@ -244831,6 +350674,109 @@ property_value: RO:0002171 UBERON:0002704 {source="ABA"} property_value: UBPROP:0000001 "The ventral nuclear group is a collection of nuclei on the ventral side of the thalamus. According to MeSH, it consists of the following: ventral anterior nucleus ventral lateral nucleus ventral posterior nucleus [WP,unvetted][Wikipedia:Ventral_nuclear_group]." xsd:string {source="Wikipedia:Ventral_nuclear_group"} property_value: UBPROP:0000012 "consider splitting nucleus from nuclear group (FMA has 'nucleus of subthalamus') - but note this is also treated as a nucleus (singular) in FMA. ZFA:0005576 represents an individual nucleus within the group" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0002787 +name: decussation of trochlear nerve +is_a: UBERON:0007418 ! neural decussation +intersection_of: UBERON:0007418 ! neural decussation +intersection_of: extends_fibers_into UBERON:0001644 ! trochlear nerve +relationship: extends_fibers_into UBERON:0001644 ! trochlear nerve +relationship: part_of UBERON:0003023 ! pontine tegmentum + +[Term] +id: UBERON:0002792 +name: lumbar spinal cord +is_a: UBERON:0005844 ! spinal cord segment +intersection_of: UBERON:0005844 ! spinal cord segment +intersection_of: part_of UBERON:0005462 ! lower back +relationship: part_of UBERON:0005462 ! lower back + +[Term] +id: UBERON:0002802 +name: left parietal lobe +is_a: UBERON:0001872 ! parietal lobe +intersection_of: UBERON:0001872 ! parietal lobe +intersection_of: part_of UBERON:0002812 ! left cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + +[Term] +id: UBERON:0002803 +name: right parietal lobe +is_a: UBERON:0001872 ! parietal lobe +intersection_of: UBERON:0001872 ! parietal lobe +intersection_of: part_of UBERON:0002813 ! right cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + +[Term] +id: UBERON:0002804 +name: left limbic lobe +is_a: UBERON:0002600 ! limbic lobe +intersection_of: UBERON:0002600 ! limbic lobe +intersection_of: part_of UBERON:0002812 ! left cerebral hemisphere +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + +[Term] +id: UBERON:0002805 +name: right limbic lobe +is_a: UBERON:0002600 ! limbic lobe +intersection_of: UBERON:0002600 ! limbic lobe +intersection_of: part_of UBERON:0002813 ! right cerebral hemisphere +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + +[Term] +id: UBERON:0002806 +name: left occipital lobe +is_a: UBERON:0002021 ! occipital lobe +intersection_of: UBERON:0002021 ! occipital lobe +intersection_of: part_of UBERON:0002812 ! left cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + +[Term] +id: UBERON:0002807 +name: right occipital lobe +is_a: UBERON:0002021 ! occipital lobe +intersection_of: UBERON:0002021 ! occipital lobe +intersection_of: part_of UBERON:0002813 ! right cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + +[Term] +id: UBERON:0002808 +name: left temporal lobe +is_a: UBERON:0001871 ! temporal lobe +intersection_of: UBERON:0001871 ! temporal lobe +intersection_of: part_of UBERON:0002812 ! left cerebral hemisphere +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + +[Term] +id: UBERON:0002809 +name: right temporal lobe +is_a: UBERON:0001871 ! temporal lobe +intersection_of: UBERON:0001871 ! temporal lobe +intersection_of: part_of UBERON:0002813 ! right cerebral hemisphere +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + +[Term] +id: UBERON:0002810 +name: right frontal lobe +is_a: UBERON:0001870 ! frontal cortex +intersection_of: UBERON:0001870 ! frontal cortex +intersection_of: part_of UBERON:0002813 ! right cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + +[Term] +id: UBERON:0002811 +name: left frontal lobe +is_a: UBERON:0001870 ! frontal cortex +intersection_of: UBERON:0001870 ! frontal cortex +intersection_of: part_of UBERON:0002812 ! left cerebral hemisphere +relationship: adjacent_to UBERON:0002921 ! longitudinal fissure +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + [Term] id: UBERON:0002812 name: left cerebral hemisphere @@ -244882,9 +350828,9 @@ xref: BAMS:GvVIII xref: BIRNLEX:2549 xref: EMAPA:17573 xref: FMA:53435 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=495 {source="BIRNLEX:2549"} xref: MA:0001086 xref: NCIT:C33870 +xref: neuronames:495 {source="BIRNLEX:2549"} xref: RETIRED_EHDAA2:0002199 xref: SCTID:244450009 xref: UMLS:C0036286 {source="BIRNLEX:2549"} @@ -244897,6 +350843,9 @@ is_a: UBERON:0001800 {source="ncithesaurus"} ! sensory ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system is_a: UBERON:0006585 ! vestibular organ is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001714 ! cranial ganglion +intersection_of: extends_fibers_into UBERON:0003723 ! vestibular nerve +relationship: extends_fibers_into UBERON:0003723 ! vestibular nerve relationship: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0002827 ! vestibulocochlear ganglion @@ -244948,8 +350897,8 @@ xref: EHDAA:5569 xref: EHDAA:6653 xref: EMAPA:16982 xref: EMAPA:17571 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=496 {source="BIRNLEX:2564"} xref: MA:0001084 +xref: neuronames:496 {source="BIRNLEX:2564"} xref: TAO:0000588 xref: UMLS:C0037959 {source="BIRNLEX:2564"} xref: VHOG:0000696 @@ -245023,11 +350972,11 @@ xref: EMAPA:35416 xref: EV:0100286 xref: FMA:54505 xref: HBA:9557 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 {source="BIRNLEX:2644"} xref: MA:0001039 xref: MBA:773 xref: NCIT:C12899 xref: ncithesaurus:Nucleus_of_the_Hypoglossal_Nerve +xref: neuronames:757 {source="BIRNLEX:2644"} xref: SCTID:47361005 xref: UMLS:C0228802 {source="ncithesaurus:Hypoglossal_Nucleus"} xref: UMLS:C0228802 {source="BIRNLEX:2644"} @@ -245068,8 +351017,9 @@ xref: EHDAA:5482 xref: EMAPA:17779 xref: FMA:276600 xref: HBA:265504406 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2275 xref: MA:0000193 +xref: MESH:D066194 +xref: neuronames:2275 xref: UMLS:C0162434 {source="BIRNLEX:2707"} xref: VHOG:0000325 xref: Wikipedia:Olfactory_cortex @@ -245097,14 +351047,19 @@ xref: BAMS:ccis xref: BIRNLEX:4003 xref: EMAPA:19057 xref: FMA:74515 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=30 {source="BIRNLEX:4003"} xref: NCIT:C32304 +xref: neuronames:30 {source="BIRNLEX:4003"} xref: SCTID:47947006 xref: UMLS:C0228152 {source="ncithesaurus:Chiasmatic_Cistern"} xref: UMLS:C0228152 {source="BIRNLEX:4003"} xref: Wikipedia:Chiasmatic_cistern is_a: UBERON:0004050 ! subarachnoid cistern +[Term] +id: UBERON:0002921 +name: longitudinal fissure +is_a: UBERON:0014466 ! subarachnoid fissure + [Term] id: UBERON:0002925 name: trigeminal nucleus @@ -245152,6 +351107,15 @@ intersection_of: part_of UBERON:0001033 ! gustatory system relationship: part_of UBERON:0000012 {source="NIFSTD"} ! somatic nervous system relationship: part_of UBERON:0001033 ! gustatory system +[Term] +id: UBERON:0002928 +name: dentate gyrus polymorphic layer +is_a: UBERON:0002304 ! layer of dentate gyrus +intersection_of: UBERON:0002304 ! layer of dentate gyrus +intersection_of: immediately_deep_to UBERON:0005381 ! dentate gyrus granule cell layer +relationship: composed_primarily_of CL:0000540 ! neuron +relationship: immediately_deep_to UBERON:0005381 ! dentate gyrus granule cell layer + [Term] id: UBERON:0002956 name: granular layer of cerebellar cortex @@ -245172,12 +351136,18 @@ xref: BTO:0004425 xref: CALOHA:TS-1247 xref: EMAPA:35217 xref: FMA:83140 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=363 {source="BIRNLEX:779"} xref: MA:0000993 xref: MBA:1143 xref: NCIT:C49138 +xref: neuronames:363 {source="BIRNLEX:779"} xref: UMLS:C1708253 {source="ncithesaurus:Granular_Layer_of_the_Cerebellum"} is_a: UBERON:0004130 ! cerebellar layer +intersection_of: UBERON:0004130 ! cerebellar layer +intersection_of: BSPO:0001101 UBERON:0002129 ! cerebellar cortex +relationship: BSPO:0001101 UBERON:0002129 ! cerebellar cortex +relationship: has_part CL:0000119 ! cerebellar Golgi cell +relationship: has_part CL:0000555 ! neuronal brush cell +relationship: has_part CL:0001031 ! cerebellar granule cell property_value: RO:0002171 UBERON:0002979 {source="ABA"} [Term] @@ -245195,7 +351165,7 @@ xref: BIRNLEX:794 xref: DHBA:10443 xref: FMA:62164 xref: HBA:12929 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=318 {source="BIRNLEX:794"} +xref: neuronames:318 {source="BIRNLEX:794"} xref: UMLS:C0175263 {source="BIRNLEX:794"} is_a: UBERON:0015233 ! nucleus of dorsal thalamus relationship: part_of UBERON:0002733 {source="FMA"} ! intralaminar nuclear group @@ -245205,6 +351175,7 @@ id: UBERON:0002967 name: cingulate gyrus namespace: uberon def: "One of the convolutions on the medial surface of the cerebral hemisphere. It surrounds the rostral part of the brain and interhemispheric commissure and forms part of the limbic system. (MSH) One of three essential structures comprising the limbic lobe, the other two being the hippocampus and parahippocampal gyrus. (CSP)." [BIRNLEX:798] +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "cingular gyrus" RELATED [NeuroNames:159] @@ -245221,8 +351192,8 @@ xref: BTO:0003976 xref: DHBA:12156 xref: FMA:62434 xref: HBA:4220 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=159 {source="BIRNLEX:798"} xref: NCIT:C96217 +xref: neuronames:159 {source="BIRNLEX:798"} xref: SCTID:279208003 xref: UMLS:C0018427 {source="BIRNLEX:798"} xref: UMLS:C0018427 {source="ncithesaurus:Cingulate_Gyrus"} @@ -245230,12 +351201,14 @@ xref: Wikipedia:Cingulate_gyrus is_a: UBERON:0000200 ! gyrus relationship: part_of UBERON:0000349 ! limbic system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray727_cingulate_gyrus.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002973 name: parahippocampal gyrus namespace: uberon def: "Component of the temporal lobe on the mesial surface, posterior to the entorhinal cortex. The rostral and caudal boundaries are the posterior end of the netorhinal cortex and the caudal portion of the hippocampus, respectively. The medial boudnary is designated as the medial aspect off the temporal lobe and the lateral boundary is the collateral sulcus (Christine Fennema-Notestine)." [BIRNLEX:807] +subset: human_reference_atlas subset: uberon_slim synonym: "gyrus hippocampi" RELATED LATIN [NeuroNames:164] synonym: "gyrus parahippocampalis" RELATED LATIN [Wikipedia:Parahippocampal_gyrus] @@ -245251,9 +351224,9 @@ xref: EV:0100181 xref: FMA:61918 xref: GAID:634 xref: HBA:4242 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=164 {source="BIRNLEX:807"} -xref: MESH:A08.186.211.577.710 +xref: MESH:D020534 xref: NCIT:C33262 +xref: neuronames:164 {source="BIRNLEX:807"} xref: SCTID:279205000 xref: UMLS:C0228249 {source="ncithesaurus:Parahippocampal_Gyrus"} xref: UMLS:C0228249 {source="BIRNLEX:807"} @@ -245263,6 +351236,7 @@ relationship: part_of UBERON:0000349 {source="FMA"} ! limbic system relationship: part_of UBERON:0001871 {source="FMA"} ! temporal lobe relationship: part_of UBERON:0002600 {source="FMA", source="NIF"} ! limbic lobe property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002974 @@ -245281,10 +351255,10 @@ xref: BIRNLEX:810 xref: CALOHA:TS-1248 xref: EMAPA:35221 xref: FMA:83897 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=366 {source="BIRNLEX:810"} xref: MA:0000996 xref: MBA:1144 xref: NCIT:C49139 +xref: neuronames:366 {source="BIRNLEX:810"} xref: SCTID:369045002 xref: UMLS:C0228469 {source="BIRNLEX:810"} xref: UMLS:C1289474 {source="BIRNLEX:810"} @@ -245313,10 +351287,10 @@ xref: BIRNLEX:818 xref: BTO:0004909 xref: EMAPA:35223 xref: FMA:83896 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=365 {source="BIRNLEX:818"} xref: MA:0000997 xref: MBA:1145 xref: NCIT:C49140 +xref: neuronames:365 {source="BIRNLEX:818"} xref: SCTID:369046001 xref: UMLS:C0228469 {source="BIRNLEX:818"} xref: UMLS:C1289475 {source="BIRNLEX:818"} @@ -245349,7 +351323,7 @@ xref: BAMS:mthh xref: BIRNLEX:855 xref: EMAPA:37904 {source="MA:th"} xref: FMA:62059 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=424 {source="BIRNLEX:855"} +xref: neuronames:424 {source="BIRNLEX:855"} xref: SCTID:369139008 xref: UMLS:C0228375 {source="BIRNLEX:855"} xref: UMLS:C1289566 {source="BIRNLEX:855"} @@ -245382,8 +351356,8 @@ xref: BIRNLEX:903 xref: DMBA:17317 xref: FMA:54582 xref: HBA:9142 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=586 {source="BIRNLEX:903"} xref: MBA:661 +xref: neuronames:586 {source="BIRNLEX:903"} xref: TAO:0000206 xref: UMLS:C0175442 {source="BIRNLEX:903"} xref: Wikipedia:Facial_motor_nucleus @@ -245418,8 +351392,8 @@ xref: DHBA:12852 xref: EV:0100297 xref: FMA:72253 xref: HBA:12944 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=679 xref: MA:0002965 +xref: neuronames:679 xref: SCTID:279361008 xref: Wikipedia:Flocculonodular_lobe is_a: UBERON:0005293 ! cerebellum lobe @@ -245445,8 +351419,8 @@ xref: BAMS:CENT xref: BAMS:CLb xref: BIRNLEX:920 xref: FMA:72519 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=658 xref: MBA:920 +xref: neuronames:658 xref: SCTID:279383007 xref: Wikipedia:Central_lobule is_a: UBERON:0004070 ! cerebellum vermis lobule @@ -245460,6 +351434,7 @@ id: UBERON:0003023 name: pontine tegmentum namespace: uberon def: "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." [BIRNLEX:923] +subset: human_reference_atlas subset: uberon_slim synonym: "dorsal pons" EXACT [] synonym: "dorsal portion of pons" EXACT [FMA:71108] @@ -245474,11 +351449,11 @@ xref: BIRNLEX:923 xref: DHBA:12416 xref: FMA:71108 xref: HBA:9135 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=557 {source="BIRNLEX:923"} +xref: MESH:D065821 +xref: neuronames:557 {source="BIRNLEX:923"} xref: SCTID:362401009 xref: UMLS:C0228426 {source="BIRNLEX:923"} xref: Wikipedia:Pontine_tegmentum -is_a: BFO:0000040 ! material entity is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -245487,7 +351462,8 @@ relationship: has_part UBERON:0002128 ! superior olivary complex relationship: has_part UBERON:0002148 ! locus ceruleus relationship: has_part UBERON:0002149 ! superior salivatory nucleus relationship: part_of UBERON:0000988 ! pons -property_value: depicted:by Brainstem:Abducens.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum]" xsd:string [Term] @@ -245531,7 +351507,6 @@ xref: FMA:86461 xref: http://en.wikipedia.org/wiki/Septum xref: OpenCyc:Mx4rrqot_on_EdaAAAACs0uFOQ xref: Wikipedia:Septum -is_a: BFO:0000040 ! material entity is_a: UBERON:0000061 ! anatomical structure relationship: located_in UBERON:0002553 ! anatomical cavity property_value: UBPROP:0000007 "septal" xsd:string @@ -245550,9 +351525,9 @@ synonym: "thoracic segments of spinal cord [1-12]" EXACT [FMA:71167] synonym: "thoracic spinal cord" EXACT [FMA:71167] xref: BIRNLEX:966 xref: FMA:71167 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1718 xref: MA:0003082 xref: NCIT:C12894 +xref: neuronames:1718 xref: SCTID:278750009 xref: UMLS:C0581620 {source="ncithesaurus:Thoracic_Spinal_Cord"} xref: UMLS:C0581620 {source="BIRNLEX:966"} @@ -245589,8 +351564,8 @@ xref: BAMS:aco xref: BIRNLEX:969 xref: EMAPA:37404 {source="MA:th"} xref: FMA:61963 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=206 xref: MBA:900 +xref: neuronames:206 is_a: UBERON:0019294 ! commissure of telencephalon relationship: part_of UBERON:0000935 ! anterior commissure @@ -245606,7 +351581,7 @@ synonym: "trigeminal nerve tract" EXACT [FMA:72501] xref: BAMS:5nf xref: BIRNLEX:974 xref: FMA:72501 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=607 {source="BIRNLEX:974"} +xref: neuronames:607 {source="BIRNLEX:974"} xref: UMLS:C0175452 {source="BIRNLEX:974"} is_a: UBERON:0006134 ! nerve fiber intersection_of: UBERON:0006134 ! nerve fiber @@ -245634,8 +351609,8 @@ xref: BAMS:act xref: BIRNLEX:977 xref: EMAPA:37410 {source="MA:th"} xref: FMA:61964 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=207 xref: MBA:908 +xref: neuronames:207 xref: UMLS:C0175210 {source="BIRNLEX:977"} is_a: UBERON:0019294 ! commissure of telencephalon relationship: part_of UBERON:0000935 ! anterior commissure @@ -245702,7 +351677,11 @@ is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0007499 ! epithelial sac +intersection_of: has_potential_to_develop_into UBERON:0001846 ! internal ear +intersection_of: part_of UBERON:0000924 ! ectoderm relationship: develops_from UBERON:0006273 ! otic pit +relationship: has_potential_to_develop_into UBERON:0001846 ! internal ear relationship: part_of UBERON:0000924 ! ectoderm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray40.png xsd:anyURI property_value: UBPROP:0000001 "Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000051", ontology="TAO", source="ZFIN:curator"} @@ -245733,6 +351712,7 @@ xref: EHDAA:5789 xref: EMAPA:32857 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2076 xref: NCIT:C93172 +xref: neuronames:2076 xref: TAO:0000042 xref: VHOG:0000649 xref: XAO:0000016 @@ -245774,7 +351754,7 @@ xref: EHDAA:2891 xref: EHDAA:916 xref: EMAPA:16168 xref: EMAPA:35361 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1371 +xref: neuronames:1371 xref: TAO:0001436 xref: TAO:0007058 xref: VHOG:0000303 @@ -245783,6 +351763,8 @@ xref: ZFA:0007058 is_a: UBERON:0000119 ! cell layer is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue +relationship: BSPO:0015101 UBERON:0001049 ! neural tube +relationship: composed_primarily_of CL:0000125 ! glial cell relationship: part_of UBERON:0001049 ! neural tube property_value: editor_note "TODO - Note that although this is classically defined as being located on the neural tube, in many AOs the roof plate continues post-embryonically after the neural tube has ceased to exist. Consider 'roof plate of neural tube'. TODO - alar plate vs roof plate" xsd:string property_value: UBPROP:0000001 "Multi-tissue structure that is the dorsal-most aspect of the devleloping neural tube.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007058", ontology="TAO", source="ZFIN:curator"} @@ -245852,8 +351834,8 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0003075 ! neural plate relationship: posterior_to UBERON:0009615 ! midbrain hindbrain boundary neural plate -property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001201", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001201", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28"} +property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001201", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"} [Term] id: UBERON:0003059 @@ -245998,7 +351980,7 @@ xref: EHDAA:549 xref: EMAPA:16075 xref: FMA:293116 xref: GAID:1312 -xref: MESH:A16.254.650 +xref: MESH:D020897 xref: NCIT:C34266 xref: SCTID:361464001 xref: TAO:0000071 @@ -246296,6 +352278,7 @@ xref: TAO:0001202 xref: UMLS:C0231109 {source="ncithesaurus:Optic_Cup"} xref: VHOG:0000167 xref: ZFA:0001202 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: developmentally_induced_by UBERON:0003073 ! lens placode @@ -246332,6 +352315,7 @@ xref: VHOG:0000166 xref: Wikipedia:Lens_placode xref: XAO:0000240 xref: ZFA:0000122 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye @@ -246372,6 +352356,7 @@ xref: GAID:1315 xref: http://linkedlifedata.com/resource/umls/id/C0043204 xref: http://www.snomedbrowser.com/Codes/Details/308800003 xref: MESH:A16.254.940 +xref: MESH:D014928 xref: Mesonephric:duct xref: NCIT:C26469 xref: SCTID:308800003 @@ -246419,8 +352404,10 @@ xref: EMAPA:35593 xref: FMA:293879 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1362 xref: http://linkedlifedata.com/resource/umls/id/C0920623 +xref: MESH:D054258 xref: NCIT:C34225 xref: Neural:plate +xref: neuronames:1362 xref: RETIRED_EHDAA2:0001252 xref: TAO:0000132 xref: UMLS:C0920623 {source="ncithesaurus:Neural_Plate"} @@ -246428,6 +352415,7 @@ xref: VHOG:0000068 xref: Wikipedia:Neural_plate xref: XAO:0000249 xref: ZFA:0000132 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system @@ -246435,6 +352423,7 @@ relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! n relationship: develops_from UBERON:0007284 ! presumptive neural plate relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png xsd:anyURI property_value: depicted:by Neural:Crest.png xsd:anyURI property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28"} @@ -246677,7 +352666,6 @@ xref: VHOG:0000062 xref: Wikipedia:Trunk_neural_crest xref: XAO:0000319 xref: ZFA:0001024 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -246713,6 +352701,18 @@ property_value: UBPROP:0000001 "Bilateral groups of cells consisting of three ro property_value: UBPROP:0000001 "The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011044", ontology="AAO", source="XAO:curator"} property_value: UBPROP:0000002 "relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000028", ontology="TAO"} +[Term] +id: UBERON:0003086 +name: caudal artery +is_a: UBERON:0003513 ! trunk blood vessel +is_a: UBERON:0003524 ! tail blood vessel +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0005805 ! dorsal aorta +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: branching_part_of UBERON:0005805 ! dorsal aorta +relationship: part_of UBERON:2001073 ! axial vasculature + [Term] id: UBERON:0003087 name: anterior cardinal vein @@ -246773,7 +352773,7 @@ xref: ZFA:0001080 is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite -relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png xsd:anyURI property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"} @@ -246905,7 +352905,6 @@ xref: VHOG:0000063 xref: Wikipedia:Cranial_neural_crest xref: XAO:0001001 xref: ZFA:0001194 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -246937,6 +352936,8 @@ xref: TGMA:0001839 xref: XAO:0003005 xref: ZFA:0000303 is_a: UBERON:0000468 ! multicellular organism +disjoint_from: UBERON:0003101 ! male organism +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl property_value: RO:0002171 UBERON:0003101 [Term] @@ -247045,7 +353046,6 @@ xref: VHOG:0000170 xref: Wikipedia:Mesenchyme xref: XAO:0003046 xref: ZFA:0000393 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell @@ -247290,6 +353290,11 @@ property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is property_value: UBPROP:0000012 "in XAO, called branchial arch 2 and df VP4" xsd:string {external_ontology="XAO"} property_value: UBPROP:0000103 "4" xsd:nonNegativeInteger +[Term] +id: UBERON:0003116 +name: pharyngeal arch 5 +is_a: UBERON:0002539 ! pharyngeal arch + [Term] id: UBERON:0003117 name: pharyngeal arch 6 @@ -247461,6 +353466,14 @@ property_value: UBPROP:0000001 "The forth in a series paired arterial connection property_value: UBPROP:0000001 "The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch; while the fourth left arch constitutes the arch of the aorta between the origin of the left carotid artery and the termination of the ductus arteriosus[WP][Wikipedia:Aortic_arches#Arch_4]." xsd:string {source="Wikipedia:Aortic_arches#Arch_4"} property_value: UBPROP:0000011 "Normally, the left fourth arch becomes the aortic arch, the right fourth arch contributes to the innominate artery[http://emedicine.medscape.com/article/899609-overview] in birds it is the right fourth arch which forms the permanent aorta" xsd:string +[Term] +id: UBERON:0003122 +name: pharyngeal arch artery 5 +is_a: UBERON:0004363 ! pharyngeal arch artery +intersection_of: UBERON:0004363 ! pharyngeal arch artery +intersection_of: part_of UBERON:0003116 ! pharyngeal arch 5 +relationship: part_of UBERON:0003116 ! pharyngeal arch 5 + [Term] id: UBERON:0003123 name: pharyngeal arch artery 6 @@ -247500,8 +353513,10 @@ property_value: UBPROP:0000011 "the distal left sixth arch becomes the ductus ar id: UBERON:0003124 name: chorion membrane namespace: uberon -def: "The outermost extraembryonic membrane." [MESH:A10.615.284.473, MP:0002836] +def: "The outermost extraembryonic membrane of amniotes." [http://orcid.org/0000-0002-6601-2165, https://github.com/geneontology/go-ontology/issues/22603, MESH:A10.615.284.473, MP:0002836] +comment: This term refers to the amniote structure. It is distinct from the concept of chorion in insects subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "chorion" EXACT [] @@ -247520,7 +353535,7 @@ xref: EMAPA:16112 xref: EV:0100121 xref: FMA:80224 xref: GAID:1299 -xref: MESH:A16.254.403.473 +xref: MESH:D002823 xref: NCIT:C34122 xref: NCIT:C34124 xref: UMLS:C0008503 {source="ncithesaurus:Chorion"} @@ -247529,8 +353544,13 @@ xref: VHOG:0000200 xref: Wikipedia:Chorion is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005631 ! extraembryonic membrane +relationship: adjacent_to UBERON:0000922 ! embryo relationship: develops_from UBERON:0005971 {source="ISBN:0073040584"} ! amniotic fold +relationship: has_part UBERON:0003265 ! chorionic mesenchyme +relationship: has_part UBERON:0003374 ! chorionic ectoderm +relationship: only_in_taxon NCBITaxon:32524 {source="Hymans"} ! Amniota property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000200", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/chorion"} property_value: UBPROP:0000001 "The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252]." xsd:string {source="BTO:0000252"} property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000200", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"} @@ -247544,6 +353564,7 @@ name: trachea namespace: uberon def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [GO:0060438, Wikipedia:Vertebrate_trachea] subset: efo_slim +subset: human_reference_atlas subset: major_organ subset: pheno_slim subset: uberon_slim @@ -247573,10 +353594,14 @@ xref: VHOG:0000371 xref: Wikipedia:Vertebrate_trachea xref: XAO:0000118 is_a: UBERON:0000117 ! respiratory tube +relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium +relationship: located_in UBERON:0002224 ! thoracic cavity +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0007196 ! tracheobronchial tree property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "An elongated tube which carries air to and from the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010140", ontology="AAO", source="AAO:BJB"} property_value: UBPROP:0000001 "The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000371", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000371", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.409", source="http://bgee.unil.ch/"} @@ -247741,6 +353766,8 @@ synonym: "sex organ of male organism" EXACT [OBOL:automatic] xref: MA:0000545 xref: WBbt:0008423 is_a: UBERON:0003133 ! reproductive organ +intersection_of: UBERON:0003133 ! reproductive organ +intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0000079 ! male reproductive system [Term] @@ -247795,6 +353822,9 @@ xref: FMA:73285 xref: MA:0002760 is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003215 ! alveolus +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: contributes_to_morphology_of UBERON:0001912 ! lobule of mammary gland relationship: part_of UBERON:0001912 ! lobule of mammary gland [Term] @@ -247836,7 +353866,7 @@ xref: Wikipedia:Hard_palate is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000477 {source="FMA"} ! anatomical cluster relationship: part_of UBERON:0001716 {notes="check this", source="EMAPA"} ! secondary palate -property_value: depicted:by Illu:mouth.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/f6/Illu_mouth.jpg xsd:anyURI property_value: UBPROP:0000012 "in FMA this is divided into bony parts and submucosa" xsd:string {external_ontology="FMA"} [Term] @@ -247874,6 +353904,7 @@ xref: Metanephric:blastema xref: SCTID:361529008 xref: VHOG:0000540 xref: Wikipedia:Metanephric_blastema +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0003918 ! kidney mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -247913,11 +353944,59 @@ xref: Wikipedia:Phalanx_bones is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0012357 ! digitopodium bone is_a: UBERON:0015023 ! phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010701 ! phalanx cartilage element relationship: part_of UBERON:5102544 ! individual digit of digitopodial skeleton property_value: UBPROP:0000007 "phalangeal" xsd:string property_value: UBPROP:0000008 "In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three" xsd:string {source="WP"} +[Term] +id: UBERON:0003229 +name: epithelium of elbow +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001461 ! elbow +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0001461 ! elbow + +[Term] +id: UBERON:0003230 +name: epithelium of carpal region +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0004452 ! carpal region +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0004452 ! carpal region + +[Term] +id: UBERON:0003231 +name: epithelium of hip +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001464 ! hip +relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm +relationship: part_of UBERON:0001464 ! hip + +[Term] +id: UBERON:0003232 +name: epithelium of knee +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001465 ! knee +relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm +relationship: part_of UBERON:0001465 ! knee + +[Term] +id: UBERON:0003233 +name: epithelium of shoulder +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001467 ! shoulder +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0001467 ! shoulder + [Term] id: UBERON:0003235 name: epithelium of upper jaw @@ -247935,6 +354014,8 @@ xref: EHDAA:8027 xref: EMAPA:17943 xref: EMAPA:18971 is_a: UBERON:0035037 ! jaw epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: part_of UBERON:0001709 ! upper jaw region [Term] @@ -247981,9 +354062,42 @@ xref: NCIT:C12937 xref: UMLS:C0596882 {source="ncithesaurus:Mammary_Epithelium"} xref: VHOG:0001088 is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: contributes_to_morphology_of UBERON:0001911 ! mammary gland relationship: develops_from UBERON:0011272 {source="EHDAA2", source="Wikipathways:WP2062"} ! embryonic skin basal layer relationship: part_of UBERON:0001911 ! mammary gland +[Term] +id: UBERON:0003246 +name: epithelium of endolymphatic sac +is_a: UBERON:0006937 ! inner ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: adjacent_to UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0002223 ! endolymphatic sac +relationship: adjacent_to UBERON:0000464 ! anatomical space +relationship: part_of UBERON:0002223 ! endolymphatic sac + +[Term] +id: UBERON:0003247 +name: epithelium of forearm +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0002386 ! forelimb zeugopod + +[Term] +id: UBERON:0003248 +name: epithelium of footplate +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0006871 ! embryonic footplate +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0006871 ! embryonic footplate + [Term] id: UBERON:0003249 name: epithelium of otic placode @@ -248001,6 +354115,8 @@ xref: ZFA:0007068 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0015807 ! ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003069 ! otic placode relationship: part_of UBERON:0003069 ! otic placode property_value: editor_note "check ZFA, placemeant, appears to refer to both adult structures and primordium" xsd:string @@ -248021,11 +354137,46 @@ xref: Wikipedia:Human_rib_cage xref: Wikipedia:Rib_cage is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010912 ! subdivision of skeleton +relationship: contributes_to_morphology_of UBERON:0005944 ! axial skeleton plus cranial skeleton relationship: part_of UBERON:0014477 ! thoracic skeleton relationship: part_of UBERON:0014478 ! rib skeletal system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/88/Gray112.png xsd:anyURI property_value: UBPROP:0000001 "Anatomical cluster that consists of more than one rib in an individual.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002100", ontology="TAO", source="TAO:wd"} +[Term] +id: UBERON:0003253 +name: neck of rib +is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0002228 ! rib +relationship: part_of UBERON:0010388 ! proximal segment of rib + +[Term] +id: UBERON:0003254 +name: amniotic ectoderm +is_a: UBERON:0000478 ! extraembryonic structure +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010303 ! extraembryonic epithelium +is_a: UBERON:0012275 ! meso-epithelium +relationship: part_of UBERON:0000305 ! amnion + +[Term] +id: UBERON:0003257 +name: yolk sac endoderm +namespace: uberon +def: "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." [UBERON:cjm] +xref: EHDAA2:0002215 +xref: EHDAA:166 +xref: EMAPA:16086 +xref: VHOG:0000626 +is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0010303 ! extraembryonic epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: bounding_layer_of UBERON:0001040 ! yolk sac +intersection_of: develops_from UBERON:0000925 ! endoderm +relationship: bounding_layer_of UBERON:0001040 ! yolk sac + [Term] id: UBERON:0003258 name: endoderm of foregut @@ -248076,6 +354227,54 @@ intersection_of: develops_from UBERON:0000925 ! endoderm intersection_of: part_of UBERON:0001046 ! hindgut property_value: editor_note "TODO - check" xsd:string +[Term] +id: UBERON:0003261 +name: thyroid primordium endoderm +is_a: UBERON:0000925 ! endoderm +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000925 ! endoderm +intersection_of: part_of UBERON:0003091 ! thyroid primordium +relationship: develops_from UBERON:0007690 ! early pharyngeal endoderm +relationship: part_of UBERON:0003091 ! thyroid primordium + +[Term] +id: UBERON:0003262 +name: amniotic mesoderm +is_a: UBERON:0000478 ! extraembryonic structure +is_a: UBERON:0007524 ! dense mesenchyme tissue +is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0000305 ! amnion +relationship: part_of UBERON:0000305 ! amnion + +[Term] +id: UBERON:0003265 +name: chorionic mesenchyme +namespace: uberon +alt_id: UBERON:0003423 +def: "A mesenchyme that is part of a chorion." [OBOL:automatic] +subset: human_reference_atlas +synonym: "chorion mesenchyme" EXACT [OBOL:automatic] +synonym: "chorion mesoderm" EXACT [RETIRED_EHDAA2:0000247] +synonym: "chorionic mesenchyme" EXACT [EHDAA2:0003245] +synonym: "mesenchyme of chorion" EXACT [] +synonym: "mesenchyme of chorion (vertebrates)" EXACT [OBOL:automatic] +xref: EHDAA2:0003245 +xref: EHDAA:154 +xref: EMAPA:16114 +xref: EMAPA:16266 +xref: RETIRED_EHDAA2:0000247 +xref: VHOG:0000620 +is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure +is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue +is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003124 ! chorion membrane +relationship: develops_from UBERON:0004871 {source="ISBN:0073040584"} ! somatic layer of lateral plate mesoderm +relationship: part_of UBERON:0003124 ! chorion membrane +property_value: editor_note "TODO - check" xsd:string +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0003267 name: tooth of upper jaw @@ -248089,9 +354288,13 @@ xref: MA:0001909 xref: NCIT:C49792 xref: SCTID:422279005 xref: UMLS:C1710581 {source="ncithesaurus:Upper_Jaw_Tooth"} +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001091 ! calcareous tooth is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: part_of UBERON:0001709 ! upper jaw region +relationship: attaches_to UBERON:0011597 ! bone of upper jaw relationship: part_of UBERON:0009680 ! set of upper jaw teeth property_value: editor_note "Note that we follow EHDAA2 and consider teeth part of the jaw skeleton" xsd:string @@ -248114,9 +354317,13 @@ xref: MA:0001907 xref: NCIT:C49582 xref: SCTID:422032003 xref: UMLS:C1708757 {source="ncithesaurus:Lower_Jaw_Tooth"} +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001091 ! calcareous tooth is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: part_of UBERON:0001710 ! lower jaw region +relationship: attaches_to UBERON:0004768 ! bone of lower jaw relationship: part_of UBERON:0009679 ! set of lower jaw teeth [Term] @@ -248153,10 +354360,14 @@ xref: FMA:54397 xref: MA:0001908 xref: VHOG:0000429 xref: XAO:0003087 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0001709 ! upper jaw region relationship: part_of UBERON:0001708 ! jaw skeleton relationship: part_of UBERON:0001709 ! upper jaw region +relationship: skeleton_of UBERON:0001709 ! upper jaw region property_value: UBPROP:0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000429", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "EMAPA/MA placement unclear. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" xsd:string {external_ontology="EMAPA"} @@ -248183,6 +354394,7 @@ xref: TAO:0001273 xref: VHOG:0000428 xref: XAO:0003084 xref: ZFA:0001273 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -248196,6 +354408,31 @@ property_value: UBPROP:0000003 "The jaw joint of all jawed vertebrates, except f property_value: UBPROP:0000003 "The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000428", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0003279 +name: endothelium of trachea +namespace: uberon +def: "An endothelium that is part of a trachea." [OBOL:automatic] +synonym: "endothelium of windpipe" EXACT [OBOL:automatic] +synonym: "trachea endothelium" EXACT [OBOL:automatic] +synonym: "windpipe endothelium" EXACT [OBOL:automatic] +xref: EHDAA:3082 +xref: RETIRED_EHDAA2:0002068 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001901 ! epithelium of trachea +is_a: UBERON:0001986 ! endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0003126 ! trachea + +[Term] +id: UBERON:0003280 +name: endothelium of main bronchus +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001986 ! endothelium +is_a: UBERON:0002340 ! epithelium of main bronchus +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0002182 ! main bronchus + [Term] id: UBERON:0003281 name: mesentery of stomach @@ -248215,6 +354452,9 @@ xref: MA:0001617 xref: SCTID:261623000 xref: VHOG:0000358 is_a: UBERON:0004854 {source="MA"} ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0000945 ! stomach +relationship: contributes_to_morphology_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 {source="MA"} ! stomach property_value: editor_note "TODO - check primitive vs developed" xsd:string property_value: UBPROP:0000001 "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000358", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mesogastrium"} @@ -248232,8 +354472,50 @@ xref: EMAPA:16212 xref: RETIRED_EHDAA2:0000739 xref: VHOG:0000353 is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart +[Term] +id: UBERON:0003283 +name: mesentery of oesophagus +namespace: uberon +def: "A mesentery that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +synonym: "esophagus mesentery" EXACT [MA:0001569] +synonym: "gullet mesentery" EXACT [OBOL:automatic] +synonym: "mesentery of esophagus" EXACT [OBOL:automatic] +synonym: "mesentery of gullet" EXACT [OBOL:automatic] +synonym: "meso-esophagus" EXACT [] +synonym: "oesophagus mesentery" EXACT [VHOG:0000415] +xref: EHDAA2:0001288 +xref: EHDAA:2943 +xref: EMAPA:16836 +xref: MA:0001569 +xref: VHOG:0000415 +is_a: UBERON:0001975 ! serosa of esophagus +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001043 ! esophagus +property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000415", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} + +[Term] +id: UBERON:0003284 +name: mesentery of midgut +namespace: uberon +def: "A mesentery that is part of a midgut [Automatically generated definition]." [OBOL:automatic] +synonym: "midgut mesentery" EXACT [OBOL:automatic] +xref: EHDAA2:0001202 +xref: EHDAA:3031 +xref: EMAPA:16721 +xref: EMAPA:17039 +xref: EMAPA:17197 +xref: VHOG:0000413 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001045 ! midgut +relationship: part_of UBERON:0001045 ! midgut +property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000413", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} + [Term] id: UBERON:0003288 name: meninx of midbrain @@ -248456,10 +354738,61 @@ xref: VHOG:0000772 xref: ZFA:0000355 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0001891 ! midbrain +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: contributes_to_morphology_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0003054 ! roof plate property_value: UBPROP:0000001 "Roof plate that is part of the midbrain. [Bgee_curator][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000772", ontology="VHOG", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0003300 +name: roof plate of telencephalon +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0001893 ! telencephalon +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: part_of UBERON:0001893 ! telencephalon +relationship: part_of UBERON:0003054 ! roof plate + +[Term] +id: UBERON:0003301 +name: roof plate of diencephalon +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0001894 ! diencephalon +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: part_of UBERON:0001894 ! diencephalon +relationship: part_of UBERON:0003054 ! roof plate + +[Term] +id: UBERON:0003302 +name: roof plate of metencephalon +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0001895 ! metencephalon +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: part_of UBERON:0001895 ! metencephalon +relationship: part_of UBERON:0003054 ! roof plate + +[Term] +id: UBERON:0003303 +name: roof plate of medulla oblongata +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0001896 ! medulla oblongata +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: part_of UBERON:0001896 ! medulla oblongata +relationship: part_of UBERON:0003054 ! roof plate + [Term] id: UBERON:0003304 name: mesoderm blood island @@ -248556,6 +354889,8 @@ xref: EHDAA:8150 xref: EMAPA:35858 xref: VHOG:0001442 is_a: UBERON:0003855 ! gonad mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0000473 ! testis relationship: part_of UBERON:0000473 ! testis [Term] @@ -248613,6 +354948,8 @@ xref: EMAPA:16267 xref: VHOG:0000503 xref: VHOG:0000617 is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001040 ! yolk sac relationship: part_of UBERON:0001040 ! yolk sac [Term] @@ -248629,6 +354966,8 @@ xref: EHDAA:6216 xref: EMAPA:17416 xref: VHOG:0001075 is_a: UBERON:0003859 ! forelimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001461 ! elbow relationship: part_of UBERON:0001461 ! elbow [Term] @@ -248644,6 +354983,8 @@ xref: EHDAA2:0000220 xref: EHDAA:5200 xref: EMAPA:19122 is_a: UBERON:0003859 ! forelimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0004452 ! carpal region relationship: part_of UBERON:0004452 ! carpal region [Term] @@ -248662,6 +355003,8 @@ xref: EHDAA:6182 xref: EMAPA:17492 xref: VHOG:0001029 is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001464 ! hip relationship: part_of UBERON:0001464 ! hip [Term] @@ -248676,6 +355019,8 @@ xref: EHDAA:6188 xref: EMAPA:17495 xref: VHOG:0001070 is_a: UBERON:0003860 ! hindlimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001465 ! knee relationship: part_of UBERON:0001465 ! knee [Term] @@ -248690,8 +355035,21 @@ xref: EHDAA:6232 xref: EMAPA:17423 xref: VHOG:0001035 is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001467 ! shoulder relationship: part_of UBERON:0001467 ! shoulder +[Term] +id: UBERON:0003323 +name: mesenchyme of upper jaw +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0034995 ! jaw mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001709 ! upper jaw region +relationship: develops_from UBERON:0009526 ! maxillary process mesenchyme +relationship: part_of UBERON:0001709 ! upper jaw region + [Term] id: UBERON:0003324 name: mesenchyme of lower jaw @@ -248711,6 +355069,15 @@ intersection_of: part_of UBERON:0001710 ! lower jaw region relationship: develops_from UBERON:0006905 {source="EHDAA2"} ! mandibular process mesenchyme relationship: part_of UBERON:0001710 ! lower jaw region +[Term] +id: UBERON:0003325 +name: mesenchyme of pinna +is_a: UBERON:0005253 ! head mesenchyme +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001757 ! pinna +relationship: part_of UBERON:0001757 ! pinna + [Term] id: UBERON:0003326 name: mesenchyme of mammary gland @@ -248730,6 +355097,8 @@ xref: EMAPA:17761 xref: VHOG:0001087 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland [Term] @@ -248743,6 +355112,8 @@ xref: EHDAA:6222 xref: EMAPA:17419 xref: VHOG:0000504 is_a: UBERON:0003859 ! forelimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod relationship: part_of UBERON:0002386 ! forelimb zeugopod [Term] @@ -248759,6 +355130,8 @@ xref: EMAPA:17252 xref: EMAPA:17488 xref: VHOG_RETIRED:0001055 is_a: UBERON:0010377 ! mesenchyme from somatopleure +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0006871 ! embryonic footplate relationship: develops_from UBERON:0003412 {source="EHDAA2"} ! pelvic appendage bud mesenchyme relationship: part_of UBERON:0006871 ! embryonic footplate property_value: UBPROP:0000012 "We group two EMAPA classes here but these may need to be separated" xsd:string {external_ontology="EMAPA"} @@ -248768,6 +355141,7 @@ id: UBERON:0003329 name: submucosa of anal canal namespace: uberon def: "A submucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "anal canal submucosa" EXACT [OBOL:automatic] synonym: "anal canal viewed anatomically submucosa" EXACT [OBOL:automatic] synonym: "anal region submucosa" EXACT [OBOL:automatic] @@ -248780,11 +355154,13 @@ xref: EMAPA:27227 xref: EMAPA:27535 xref: FMA:85399 xref: http://www.snomedbrowser.com/Codes/Details/7892006 +xref: SCTID:7892006 is_a: UBERON:0001208 ! submucosa of large intestine is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003330 @@ -248798,6 +355174,7 @@ xref: BTO:0002114 xref: EMAPA:27083 xref: FMA:15034 xref: http://www.snomedbrowser.com/Codes/Details/71683001 +xref: SCTID:71683001 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001052 ! rectum @@ -248808,6 +355185,7 @@ id: UBERON:0003331 name: submucosa of colon namespace: uberon def: "A submucosa that is part of a colon [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "colon submucosa" EXACT [OBOL:automatic] synonym: "colonic submucosa" EXACT [FMA:14985] synonym: "large bowel submucosa" EXACT [OBOL:automatic] @@ -248816,10 +355194,41 @@ xref: EMAPA:27379 xref: FMA:14985 xref: http://www.snomedbrowser.com/Codes/Details/61647009 xref: MA:0003200 +xref: SCTID:61647009 is_a: UBERON:0001208 ! submucosa of large intestine intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003332 +name: submucosa of duodenum +namespace: uberon +def: "A submucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas +synonym: "doudenal submucosa" EXACT [FMA:14943] +synonym: "duodenal submucosa" EXACT [FMA:14943] +synonym: "duodenum submucosa" EXACT [OBOL:automatic] +xref: EMAPA:27027 +xref: EMAPA:27097 +xref: EMAPA:27239 +xref: FMA:14943 +xref: MA:0003213 +xref: SCTID:76519004 +is_a: UBERON:0001205 ! submucosa of small intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0002114 ! duodenum +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003333 +name: submucosa of jejunum +is_a: UBERON:0001205 ! submucosa of small intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002115 ! jejunum +relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0003334 @@ -248843,6 +355252,7 @@ id: UBERON:0003335 name: serosa of colon namespace: uberon def: "A serous membrane that is part of a colon [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "colon serosa" EXACT [OBOL:automatic] synonym: "colon serous membrane" EXACT [OBOL:automatic] synonym: "colonic serosa" EXACT [FMA:14990] @@ -248856,10 +355266,41 @@ xref: EMAPA:27387 xref: FMA:14990 xref: http://www.snomedbrowser.com/Codes/Details/90132000 xref: MA:0003199 +xref: SCTID:90132000 is_a: UBERON:0001209 ! serosa of large intestine intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003336 +name: serosa of duodenum +namespace: uberon +def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +synonym: "doudenal serosa" EXACT [FMA:14948] +synonym: "duodenal serosa" EXACT [FMA:14948] +synonym: "duodenum serosa" EXACT [OBOL:automatic] +synonym: "duodenum serous membrane" EXACT [OBOL:automatic] +synonym: "serous membrane of duodenum" EXACT [OBOL:automatic] +synonym: "visceral peritoneum of duodenum" EXACT [FMA:14948] +xref: EMAPA:27247 +xref: FMA:14948 +xref: MA:0003212 +xref: SCTID:1236009 +is_a: UBERON:0001206 ! serosa of small intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0002114 ! duodenum +property_value: UBPROP:0000010 "1st part serosa, 2nd - 4th adventitia" xsd:string + +[Term] +id: UBERON:0003337 +name: serosa of jejunum +is_a: UBERON:0001206 ! serosa of small intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0002115 ! jejunum +relationship: part_of UBERON:0002115 ! jejunum [Term] id: UBERON:0003338 @@ -248901,6 +355342,7 @@ id: UBERON:0003342 name: mucosa of anal canal namespace: uberon def: "A mucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "anal canal mucosa" EXACT [OBOL:automatic] synonym: "anal canal mucosa of organ" EXACT [OBOL:automatic] synonym: "anal canal mucous membrane" EXACT [OBOL:automatic] @@ -248939,12 +355381,14 @@ xref: FMA:74654 xref: http://linkedlifedata.com/resource/umls/id/C0227414 xref: http://www.snomedbrowser.com/Codes/Details/362170004 xref: NCIT:C60784 +xref: SCTID:362170004 xref: UMLS:C0227414 {source="ncithesaurus:Anal_Mucosa"} is_a: UBERON:0001207 ! mucosa of large intestine is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003343 @@ -249009,6 +355453,7 @@ xref: EMAPA:27081 xref: FMA:15033 xref: http://www.snomedbrowser.com/Codes/Details/362167003 xref: MA:0003218 +xref: SCTID:362167003 is_a: UBERON:0001207 ! mucosa of large intestine intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001052 ! rectum @@ -249136,6 +355581,25 @@ intersection_of: part_of UBERON:0001723 ! tongue relationship: contributes_to_morphology_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue +[Term] +id: UBERON:0003358 +name: epithelium of soft palate +is_a: UBERON:0003235 ! epithelium of upper jaw +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0001733 ! soft palate + +[Term] +id: UBERON:0003359 +name: epithelium of submandibular gland +is_a: UBERON:0003236 ! epithelium of lower jaw +is_a: UBERON:0004809 ! salivary gland epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001736 ! submandibular gland +relationship: part_of UBERON:0001736 ! submandibular gland + [Term] id: UBERON:0003360 name: epithelium of parotid gland @@ -249154,8 +355618,26 @@ xref: EMAPA:18538 xref: VHOG:0001434 is_a: UBERON:0003236 ! epithelium of lower jaw is_a: UBERON:0004809 ! salivary gland epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001831 ! parotid gland relationship: part_of UBERON:0001831 ! parotid gland +[Term] +id: UBERON:0003361 +name: epithelium of sublingual gland +is_a: UBERON:0004809 ! salivary gland epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001832 ! sublingual gland +relationship: part_of UBERON:0001832 ! sublingual gland + +[Term] +id: UBERON:0003362 +name: epithelium of endolymphatic duct +is_a: UBERON:0006937 ! inner ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001860 ! endolymphatic duct +relationship: part_of UBERON:0001860 ! endolymphatic duct + [Term] id: UBERON:0003364 name: epithelium of right lung @@ -249186,6 +355668,24 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002168 ! left lung relationship: part_of UBERON:0002168 ! left lung +[Term] +id: UBERON:0003366 +name: epithelium of uterine horn +is_a: UBERON:0006955 ! uterine epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002247 ! uterine horn +relationship: part_of UBERON:0002247 ! uterine horn + +[Term] +id: UBERON:0003368 +name: epithelium of hard palate +is_a: UBERON:0003235 ! epithelium of upper jaw +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003216 ! hard palate +relationship: part_of UBERON:0003216 ! hard palate + [Term] id: UBERON:0003371 name: pelvic appendage bud ectoderm @@ -249239,6 +355739,31 @@ relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm relationship: part_of UBERON:0005419 ! pectoral appendage bud +[Term] +id: UBERON:0003373 +name: ectoderm of footplate +is_a: UBERON:0000924 ! ectoderm +intersection_of: UBERON:0000924 ! ectoderm +intersection_of: part_of UBERON:0006871 ! embryonic footplate +relationship: part_of UBERON:0006871 ! embryonic footplate + +[Term] +id: UBERON:0003374 +name: chorionic ectoderm +namespace: uberon +def: "An extraembryonic structure that develops_from a ectoderm and is part of a chorion." [OBOL:automatic] +synonym: "chorion ectoderm" EXACT [OBOL:automatic] +synonym: "chorion epithelium" RELATED [] +synonym: "chorionic epithelium" RELATED [BTO:0005145] +xref: BTO:0005145 +xref: EMAPA:16113 +is_a: UBERON:0000478 ! extraembryonic structure +intersection_of: UBERON:0000478 ! extraembryonic structure +intersection_of: develops_from UBERON:0000924 ! ectoderm +intersection_of: part_of UBERON:0003124 ! chorion membrane +relationship: develops_from UBERON:0000924 {source="ISBN:0073040584"} ! ectoderm +relationship: part_of UBERON:0003124 ! chorion membrane + [Term] id: UBERON:0003379 name: cardiac muscle of right atrium @@ -249383,6 +355908,7 @@ name: smooth muscle of trachea namespace: uberon alt_id: UBERON:0004244 def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "trachea smooth muscle" EXACT [MA:0001863] synonym: "tracheal smooth muscle" EXACT [BTO:0001391] @@ -249393,7 +355919,11 @@ xref: MA:0001863 xref: NCIT:C49306 xref: UMLS:C1710458 {source="ncithesaurus:Trachea_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0003126 ! trachea +relationship: contributes_to_morphology_of UBERON:0003126 ! trachea relationship: part_of UBERON:0003126 ! trachea +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003388 @@ -249452,6 +355982,113 @@ intersection_of: UBERON:0001136 ! mesothelium intersection_of: located_in UBERON:0002402 ! pleural cavity relationship: located_in UBERON:0002402 ! pleural cavity +[Term] +id: UBERON:0003393 +name: mesentery of urinary system +namespace: uberon +def: "A mesentery that is part of a urinary system [Automatically generated definition]." [OBOL:automatic] +synonym: "excretory system mesentery" EXACT [OBOL:automatic] +synonym: "mesentery of excretory system" EXACT [OBOL:automatic] +synonym: "mesentery of renal system" EXACT [OBOL:automatic] +synonym: "mesentery of systema urinaria" EXACT [OBOL:automatic] +synonym: "renal system mesentery" EXACT [OBOL:automatic] +synonym: "systema urinaria mesentery" EXACT [OBOL:automatic] +synonym: "urinary system mesentery" EXACT [OBOL:automatic] +xref: EMAPA:17367 +xref: MA:0003233 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001008 ! renal system +relationship: part_of UBERON:0001008 ! renal system + +[Term] +id: UBERON:0003394 +name: mesentery of hindgut +namespace: uberon +def: "A mesentery that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +synonym: "hindgut mesentery" EXACT [OBOL:automatic] +xref: EMAPA:16718 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001046 ! hindgut +relationship: part_of UBERON:0001046 ! hindgut + +[Term] +id: UBERON:0003395 +name: mesentery of rectum +namespace: uberon +def: "A mesentery that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +synonym: "rectum mesentery" EXACT [OBOL:automatic] +xref: EMAPA:18664 +is_a: UBERON:0003334 ! serosa of rectum +is_a: UBERON:0004854 ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001052 ! rectum + +[Term] +id: UBERON:0003396 +name: mesentery of colon +namespace: uberon +def: "A mesentery that is part of a colon [Automatically generated definition]." [OBOL:automatic] +synonym: "colon mesentery" EXACT [OBOL:automatic] +synonym: "large bowel mesentery" EXACT [OBOL:automatic] +synonym: "large intestinal mesentery" EXACT [FMA:14645] +synonym: "mesentery of large bowel" EXACT [OBOL:automatic] +synonym: "mesentery of large intestine" EXACT [FMA:14645] +synonym: "mesocolon" EXACT [https://github.com/obophenotype/uberon/issues/1473] +xref: EMAPA:18942 +xref: FMA:14645 +xref: SCTID:245457004 +is_a: UBERON:0003335 ! serosa of colon +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 {source="FMA"} ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001155 ! colon + +[Term] +id: UBERON:0003397 +name: mesentery of duodenum +namespace: uberon +def: "A mesentery that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +synonym: "duodenum mesentery" EXACT [OBOL:automatic] +xref: EMAPA:19081 +is_a: UBERON:0001170 ! mesentery of small intestine +is_a: UBERON:0003336 ! serosa of duodenum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0002114 ! duodenum + +[Term] +id: UBERON:0003398 +name: mesentery of jejunum +is_a: UBERON:0001170 ! mesentery of small intestine +is_a: UBERON:0003337 ! serosa of jejunum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0002115 ! jejunum + +[Term] +id: UBERON:0003403 +name: skin of forearm +is_a: UBERON:0002427 ! arm skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: part_of UBERON:0002386 ! forelimb zeugopod + +[Term] +id: UBERON:0003404 +name: lobar bronchus of right lung +is_a: UBERON:0002183 ! lobar bronchus +intersection_of: UBERON:0002183 ! lobar bronchus +intersection_of: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0006518 ! right lung lobe + +[Term] +id: UBERON:0003405 +name: lobar bronchus of left lung +is_a: UBERON:0002183 ! lobar bronchus +intersection_of: UBERON:0002183 ! lobar bronchus +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0008951 ! left lung lobe + [Term] id: UBERON:0003406 name: cartilage of respiratory system @@ -249516,6 +356153,15 @@ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue +[Term] +id: UBERON:0003410 +name: oropharyngeal gland +is_a: UBERON:0003295 ! pharyngeal gland +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx + [Term] id: UBERON:0003412 name: pelvic appendage bud mesenchyme @@ -249561,6 +356207,16 @@ relationship: develops_from UBERON:0005729 ! pectoral appendage field relationship: part_of UBERON:0005419 ! pectoral appendage bud property_value: UBPROP:0000001 "Mesoderm that is part of the pectoral fin bud.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000789", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0003414 +name: mesenchyme of mandible +is_a: UBERON:0003324 ! mesenchyme of lower jaw +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001684 ! mandible +relationship: part_of UBERON:0001684 ! mandible + [Term] id: UBERON:0003416 name: mesenchyme of tongue @@ -249576,6 +356232,69 @@ intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue property_value: editor_note "TODO - develops_from" xsd:string +[Term] +id: UBERON:0003417 +name: mesenchyme of soft palate +is_a: UBERON:0003323 ! mesenchyme of upper jaw +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0001733 ! soft palate + +[Term] +id: UBERON:0003418 +name: mesenchyme of submandibular gland +is_a: UBERON:0003324 ! mesenchyme of lower jaw +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001736 ! submandibular gland +relationship: part_of UBERON:0001736 ! submandibular gland + +[Term] +id: UBERON:0003419 +name: mesenchyme of parotid +is_a: UBERON:0003324 ! mesenchyme of lower jaw +is_a: UBERON:0009891 ! facial mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001831 ! parotid gland +relationship: part_of UBERON:0001831 ! parotid gland + +[Term] +id: UBERON:0003420 +name: mesenchyme of sublingual gland +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005253 ! head mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001832 ! sublingual gland +relationship: part_of UBERON:0001832 ! sublingual gland + +[Term] +id: UBERON:0003422 +name: mesenchyme of umbilical cord +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005292 ! extraembryonic tissue +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002331 ! umbilical cord +relationship: has_part CHEBI:37395 ! mucopolysaccharide +relationship: part_of UBERON:0002331 ! umbilical cord + +[Term] +id: UBERON:0003424 +name: mesenchyme of hard palate +is_a: UBERON:0003323 ! mesenchyme of upper jaw +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003216 ! hard palate +relationship: part_of UBERON:0003216 ! hard palate + +[Term] +id: UBERON:0003425 +name: renal lymph node +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: located_in UBERON:0002113 ! kidney +relationship: located_in UBERON:0002113 ! kidney + [Term] id: UBERON:0003426 name: dermis adipose tissue @@ -249606,6 +356325,8 @@ xref: EMAPA:36499 xref: MA:0000472 is_a: UBERON:0003916 ! fat pad is_a: UBERON:0007808 ! adipose tissue of abdominal region +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0000916 ! abdomen [Term] id: UBERON:0003428 @@ -249626,6 +356347,8 @@ xref: MA:0002547 xref: XAO:0003050 is_a: UBERON:0003916 ! fat pad is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0000991 ! gonad relationship: part_of UBERON:0000991 ! gonad property_value: editor_note "consider change relationship from part_of" xsd:string property_value: UBPROP:0000001 "Anatomical structure associated with the gonads which vary in form among amphibians but are primarily composed of adipose tissue and are thought to be a source of nutrients for the gonads.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000157", ontology="AAO", source="AAO:BJB"} @@ -249667,8 +356390,50 @@ synonym: "nerve of leg" EXACT [OBOL:automatic] xref: EMAPA:37343 {source="MA:th"} xref: MA:0000673 is_a: UBERON:0003442 ! hindlimb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0000978 ! leg relationship: part_of UBERON:0000978 ! leg +[Term] +id: UBERON:0003432 +name: chest nerve +is_a: UBERON:0003824 ! nerve of thoracic segment +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0001443 ! chest +relationship: part_of UBERON:0001443 ! chest + +[Term] +id: UBERON:0003433 +name: arm nerve +is_a: UBERON:0003441 ! forelimb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0001460 ! arm +relationship: part_of UBERON:0001460 ! arm + +[Term] +id: UBERON:0003434 +name: wrist nerve +is_a: UBERON:0003448 ! manus nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0004452 ! carpal region +relationship: part_of UBERON:0004452 ! carpal region + +[Term] +id: UBERON:0003435 +name: pedal digit nerve +is_a: UBERON:0003445 ! pes nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: part_of UBERON:0001466 ! pedal digit + +[Term] +id: UBERON:0003436 +name: shoulder nerve +is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0001467 ! shoulder +relationship: part_of UBERON:0001467 ! shoulder + [Term] id: UBERON:0003437 name: eyelid nerve @@ -249680,7 +356445,11 @@ synonym: "nerve of eyelid" EXACT [OBOL:automatic] synonym: "palpebral nerve" EXACT [OBOL:automatic] xref: EMAPA:37535 {source="MA:th"} xref: MA:0001255 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0001711 ! eyelid +relationship: innervates UBERON:0001711 ! eyelid [Term] id: UBERON:0003438 @@ -249691,6 +356460,7 @@ synonym: "ciliary nerve" NARROW [] synonym: "nerve of iris" EXACT [OBOL:automatic] xref: EMAPA:35449 xref: MA:0001291 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0001769 ! iris @@ -249725,8 +356495,18 @@ xref: EMAPA:37291 {source="MA:th"} xref: MA:0000693 xref: SCTID:359923002 is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002101 ! limb relationship: part_of UBERON:0002101 ! limb +[Term] +id: UBERON:0003441 +name: forelimb nerve +is_a: UBERON:0003440 ! limb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002102 ! forelimb +relationship: part_of UBERON:0002102 ! forelimb + [Term] id: UBERON:0003442 name: hindlimb nerve @@ -249740,6 +356520,8 @@ synonym: "nerve of lower extremity" EXACT [OBOL:automatic] xref: EMAPA:37342 {source="MA:th"} xref: MA:0000664 is_a: UBERON:0003440 ! limb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002103 ! hindlimb relationship: part_of UBERON:0002103 ! hindlimb [Term] @@ -249764,6 +356546,59 @@ intersection_of: located_in UBERON:0002224 ! thoracic cavity relationship: located_in UBERON:0002224 ! thoracic cavity property_value: editor_note "consider merging with thoracic nerve. In MA the only subclass is the phrenic nerve, which arises from a cervical nerve" xsd:string +[Term] +id: UBERON:0003444 +name: pelvis nerve +namespace: uberon +def: "A nerve that is part of a pelvis [Automatically generated definition]." [OBOL:automatic] +synonym: "nerve of pelvis" EXACT [OBOL:automatic] +xref: EMAPA:37269 {source="MA:th"} +xref: MA:0000542 +is_a: UBERON:0003825 ! nerve of abdominal segment +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002355 ! pelvic region of trunk +relationship: part_of UBERON:0002355 ! pelvic region of trunk + +[Term] +id: UBERON:0003445 +name: pes nerve +is_a: UBERON:0003442 ! hindlimb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes + +[Term] +id: UBERON:0003446 +name: ankle nerve +is_a: UBERON:0003445 ! pes nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0004454 ! tarsal region +relationship: part_of UBERON:0004454 ! tarsal region + +[Term] +id: UBERON:0003447 +name: digit nerve of manus +is_a: UBERON:0003448 ! manus nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: part_of UBERON:0002389 ! manual digit + +[Term] +id: UBERON:0003448 +name: manus nerve +is_a: UBERON:0003441 ! forelimb nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002398 ! manus +relationship: part_of UBERON:0002398 ! manus + +[Term] +id: UBERON:0003449 +name: tail intervertebral disc +is_a: UBERON:0001066 ! intervertebral disk +intersection_of: UBERON:0001066 ! intervertebral disk +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0003450 name: upper jaw incisor @@ -249879,8 +356714,18 @@ synonym: "loop of Henle, inner medullary portion" EXACT [EMAPA:28352] xref: EMAPA:28352 xref: MA:0002623 is_a: UBERON:0034997 ! renal medulla loop of Henle +intersection_of: UBERON:0001288 ! loop of Henle +intersection_of: part_of UBERON:0001294 ! inner medulla of kidney relationship: part_of UBERON:0001294 ! inner medulla of kidney +[Term] +id: UBERON:0003456 +name: respiratory system lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0001004 ! respiratory system +relationship: part_of UBERON:0001004 ! respiratory system + [Term] id: UBERON:0003457 name: head bone @@ -249925,6 +356770,14 @@ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck +[Term] +id: UBERON:0003459 +name: chest bone +is_a: UBERON:0003827 ! thoracic segment bone +is_a: UBERON:0005175 ! chest organ +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0001443 ! chest + [Term] id: UBERON:0003460 name: arm bone @@ -249936,8 +356789,11 @@ synonym: "bone of upper extremity" RELATED [GAID:178] synonym: "bone organ of arm" EXACT [OBOL:automatic] xref: EMAPA:37303 {source="MA:th"} xref: MA:0000592 +xref: MESH:D050280 xref: OpenCyc:Mx4rwKTXoJwpEbGdrcN5Y29ycA is_a: UBERON:0008962 ! forelimb bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0001460 ! arm relationship: part_of UBERON:0001460 ! arm [Term] @@ -249950,6 +356806,9 @@ synonym: "bone of shoulder" EXACT [OBOL:automatic] synonym: "shoulder-articulating bone" EXACT [] xref: MA:0000631 is_a: UBERON:0010741 {notes="UBERONREF:0000003", source="MA"} ! bone of pectoral complex +intersection_of: UBERON:0001474 ! bone element +intersection_of: overlaps UBERON:0016884 ! shoulder joint +relationship: overlaps UBERON:0016884 ! shoulder joint relationship: part_of UBERON:0012475 ! skeleton of pectoral complex property_value: UBPROP:0000012 "this is a forelimb bone in MA, but this would lead to part-disjointness violations." xsd:string {external_ontology="MA"} @@ -249970,6 +356829,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0015455 xref: http://www.snomedbrowser.com/Codes/Details/181799005 xref: MA:0001482 xref: MA:0003159 +xref: MESH:D005147 xref: NCIT:C63706 xref: SCTID:181799005 xref: UMLS:C0015455 {source="ncithesaurus:Facial_Bone"} @@ -250050,6 +356910,8 @@ synonym: "zeugopod bone, upper" EXACT [OBOL:automatic] xref: EMAPA:35347 xref: MA:0000598 is_a: UBERON:0003460 ! arm bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod relationship: part_of UBERON:0010703 ! forelimb zeugopod skeleton [Term] @@ -250073,6 +356935,16 @@ is_a: UBERON:0001479 {source="MA"} ! sesamoid bone is_a: UBERON:0004251 ! hindlimb zeugopod bone is_a: UBERON:0011141 ! appendicular ossicle +[Term] +id: UBERON:0003468 +name: ureteric segment of renal artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0000056 ! ureter +relationship: branching_part_of UBERON:0001184 ! renal artery +relationship: part_of UBERON:0001184 ! renal artery +relationship: supplies UBERON:0000056 ! ureter + [Term] id: UBERON:0003469 name: respiratory system artery @@ -250085,11 +356957,24 @@ is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: part_of UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003470 +name: artery of upper lip +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0004573 ! systemic artery +is_a: UBERON:0009657 ! artery of lip +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001834 ! upper lip +relationship: branching_part_of UBERON:0001612 ! facial artery +relationship: supplies UBERON:0001834 ! upper lip + [Term] id: UBERON:0003471 name: artery of lower lip namespace: uberon def: "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." [Wikipedia:Inferior_labial_artery] +subset: human_reference_atlas synonym: "arteria labialis inferior" EXACT LATIN [Wikipedia:Inferior_labial_artery] synonym: "inferior labial artery" EXACT [FMA:49567] synonym: "inferior labial branch of facial artery" EXACT [FMA:49567] @@ -250108,6 +356993,16 @@ intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0001835 ! lower lip relationship: branching_part_of UBERON:0001612 {source="FMA"} ! facial artery relationship: supplies UBERON:0001835 ! lower lip +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003472 +name: cerebellar artery +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003496 ! head blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002037 ! cerebellum +relationship: supplies UBERON:0002037 ! cerebellum [Term] id: UBERON:0003473 @@ -250171,12 +357066,21 @@ intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0001004 ! respiratory system relationship: drains UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003477 +name: vein of upper lip +is_a: UBERON:0013136 ! vein of lip +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001834 ! upper lip +relationship: drains UBERON:0001834 ! upper lip + [Term] id: UBERON:0003478 name: vein of lower lip namespace: uberon def: "The inferior labial vein is the vein receiving blood from the lower lip." [http://en.wikipedia.org/wiki/Inferior_labial_vein] def: "The inferior labial vein is the vein receiving blood from the lower lip." [Wikipedia:Inferior_labial_vein] +subset: human_reference_atlas synonym: "inferior labial vein" EXACT [FMA:52541] synonym: "lower lip vein" EXACT [OBOL:automatic] synonym: "vena labialis inferior" EXACT LATIN [] @@ -250194,6 +357098,7 @@ intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0001835 ! lower lip relationship: drains UBERON:0001835 ! lower lip property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003479 @@ -250216,6 +357121,33 @@ is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: located_in UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003480 +name: vein of clitoris +is_a: UBERON:0001638 ! vein +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: part_of UBERON:0002411 ! clitoris + +[Term] +id: UBERON:0003481 +name: tail vein +is_a: UBERON:0001638 ! vein +is_a: UBERON:0003524 ! tail blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0003483 +name: thymus lymphoid tissue +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001744 ! lymphoid tissue +intersection_of: UBERON:0001744 ! lymphoid tissue +intersection_of: part_of UBERON:0002370 ! thymus +relationship: has_part CL:0000893 ! thymocyte +relationship: part_of UBERON:0002370 ! thymus + [Term] id: UBERON:0003484 name: eye sebaceous gland @@ -250230,6 +357162,18 @@ xref: EMAPA:37531 {source="MA:th"} xref: MA:0002452 is_a: UBERON:0003487 {source="MA"} ! skin sebaceous gland is_a: UBERON:0003605 ! eye skin gland +intersection_of: UBERON:0001821 ! sebaceous gland +intersection_of: part_of UBERON:0000019 ! camera-type eye + +[Term] +id: UBERON:0003485 +name: vagina sebaceous gland +is_a: UBERON:0001821 ! sebaceous gland +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005398 ! female reproductive gland +intersection_of: UBERON:0001821 ! sebaceous gland +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0003487 @@ -250262,6 +357206,8 @@ xref: SCTID:113191002 xref: SCTID:68037003 is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005172 ! abdomen element +intersection_of: UBERON:0001911 ! mammary gland +intersection_of: part_of UBERON:0000916 ! abdomen property_value: UBPROP:0000008 "Female mice normally have five pairs of nipples and mammary glands, three in the thoracic and two in the abdominal region. (There is an additional abdominal pair in female rats.) http://www.informatics.jax.org/greenbook/chapters/chapter13.shtml" xsd:string [Term] @@ -250451,6 +357397,14 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0000974 ! neck relationship: part_of UBERON:0000974 ! neck +[Term] +id: UBERON:0003503 +name: leg blood vessel +is_a: UBERON:0003516 ! hindlimb blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0000978 ! leg +relationship: part_of UBERON:0000978 ! leg + [Term] id: UBERON:0003504 name: respiratory system blood vessel @@ -250467,6 +357421,47 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003505 +name: trachea blood vessel +namespace: uberon +alt_id: UBERON:0003525 +def: "A blood vessel that is part of a trachea." [OBOL:automatic] +subset: human_reference_atlas +synonym: "blood vessel of trachea" EXACT [OBOL:automatic] +xref: EMAPA:35874 +xref: MA:0001852 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003504 ! respiratory system blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0003126 ! trachea +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003506 +name: chest blood vessel +is_a: UBERON:0003834 ! thoracic segment blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001443 ! chest +relationship: part_of UBERON:0001443 ! chest + +[Term] +id: UBERON:0003507 +name: arm blood vessel +is_a: UBERON:0003515 ! forelimb blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001460 ! arm +relationship: part_of UBERON:0001460 ! arm + +[Term] +id: UBERON:0003508 +name: pedal digit blood vessel +is_a: UBERON:0003521 ! pes blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: part_of UBERON:0001466 ! pedal digit + [Term] id: UBERON:0003509 name: arterial blood vessel @@ -250481,6 +357476,15 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0004572 ! arterial system relationship: part_of UBERON:0004572 ! arterial system +[Term] +id: UBERON:0003510 +name: eyelid blood vessel +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001711 ! eyelid +relationship: part_of UBERON:0001711 ! eyelid + [Term] id: UBERON:0003511 name: iris blood vessel @@ -250597,6 +357601,15 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0006544 ! kidney vasculature +[Term] +id: UBERON:0003518 +name: main bronchus blood vessel +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003504 ! respiratory system blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + [Term] id: UBERON:0003519 name: thoracic cavity blood vessel @@ -250631,6 +357644,38 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0002355 ! pelvic region of trunk relationship: part_of UBERON:0002355 ! pelvic region of trunk +[Term] +id: UBERON:0003521 +name: pes blood vessel +is_a: UBERON:0003516 ! hindlimb blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes + +[Term] +id: UBERON:0003522 +name: manual digit blood vessel +is_a: UBERON:0003523 ! manus blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: part_of UBERON:0002389 ! manual digit + +[Term] +id: UBERON:0003523 +name: manus blood vessel +is_a: UBERON:0003515 ! forelimb blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002398 ! manus +relationship: part_of UBERON:0002398 ! manus + +[Term] +id: UBERON:0003524 +name: tail blood vessel +is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0003526 name: respiratory system capillary @@ -250695,6 +357740,15 @@ intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain +[Term] +id: UBERON:0003529 +name: respiratory system lymphatic vessel endothelium +is_a: UBERON:0002042 ! lymphatic vessel endothelium +is_a: UBERON:0004807 ! respiratory system epithelium +intersection_of: UBERON:0002042 ! lymphatic vessel endothelium +intersection_of: part_of UBERON:0001004 ! respiratory system +relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel + [Term] id: UBERON:0003530 name: pedal digit skin @@ -250722,6 +357776,8 @@ xref: SCTID:181530005 xref: UMLS:C1708089 {source="ncithesaurus:Foot_Digit_Skin"} is_a: UBERON:0001513 ! skin of pes is_a: UBERON:0015249 ! digit skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0001466 ! pedal digit [Term] @@ -250802,8 +357858,120 @@ xref: SCTID:361711001 xref: UMLS:C1708318 {source="ncithesaurus:Hand_Digit_Skin"} is_a: UBERON:0001519 ! skin of manus is_a: UBERON:0015249 ! digit skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0002389 ! manual digit +[Term] +id: UBERON:0003534 +name: tail skin +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0003536 +name: right lung alveolar duct +is_a: UBERON:0002173 ! pulmonary alveolar duct +intersection_of: UBERON:0002173 ! pulmonary alveolar duct +intersection_of: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0006526 ! right lung alveolar system + +[Term] +id: UBERON:0003537 +name: left lung alveolar duct +is_a: UBERON:0002173 ! pulmonary alveolar duct +intersection_of: UBERON:0002173 ! pulmonary alveolar duct +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0006525 ! left lung alveolar system + +[Term] +id: UBERON:0003538 +name: right lung bronchiole +namespace: uberon +def: "A bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiole of right lung" EXACT [OBOL:automatic] +synonym: "lobular bronchiole of right lung" EXACT [OBOL:automatic] +synonym: "right lung lobular bronchiole" EXACT [OBOL:automatic] +xref: EMAPA:35425 +xref: MA:0001787 +xref: NCIT:C49279 +xref: SCTID:200089000 +xref: UMLS:C0225670 {source="ncithesaurus:Right_Lung_Bronchiole"} +is_a: UBERON:0002186 ! bronchiole +intersection_of: UBERON:0002186 ! bronchiole +intersection_of: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0002167 ! right lung + +[Term] +id: UBERON:0003539 +name: left lung bronchiole +namespace: uberon +def: "A bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiole of left lung" EXACT [OBOL:automatic] +synonym: "left lung lobular bronchiole" EXACT [OBOL:automatic] +synonym: "lobular bronchiole of left lung" EXACT [OBOL:automatic] +xref: EMAPA:19000 +xref: MA:0001778 +xref: NCIT:C49252 +xref: SCTID:200484003 +xref: UMLS:C0225674 {source="ncithesaurus:Left_Lung_Bronchiole"} +is_a: UBERON:0002186 ! bronchiole +intersection_of: UBERON:0002186 ! bronchiole +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0002168 ! left lung + +[Term] +id: UBERON:0003540 +name: right lung terminal bronchiole +namespace: uberon +def: "A terminal bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiolus terminalis of right lung" EXACT [OBOL:automatic] +synonym: "right lung bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "terminal bronchiole of right lung" EXACT [OBOL:automatic] +xref: EMAPA:36638 +xref: MA:0001789 +xref: NCIT:C49294 +xref: UMLS:C1709961 {source="ncithesaurus:Right_Lung_Terminal_Bronchiole"} +is_a: UBERON:0002187 ! terminal bronchiole +is_a: UBERON:0003538 ! right lung bronchiole +intersection_of: UBERON:0002187 ! terminal bronchiole +intersection_of: part_of UBERON:0002167 ! right lung + +[Term] +id: UBERON:0003541 +name: left lung terminal bronchiole +namespace: uberon +def: "A terminal bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiolus terminalis of left lung" EXACT [OBOL:automatic] +synonym: "left lung bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "terminal bronchiole of left lung" EXACT [OBOL:automatic] +xref: EMAPA:36636 +xref: MA:0001780 +xref: NCIT:C49255 +xref: UMLS:C1708675 {source="ncithesaurus:Left_Lung_Terminal_Bronchiole"} +is_a: UBERON:0002187 ! terminal bronchiole +is_a: UBERON:0003539 ! left lung bronchiole +intersection_of: UBERON:0002187 ! terminal bronchiole +intersection_of: part_of UBERON:0002168 ! left lung + +[Term] +id: UBERON:0003542 +name: right lung respiratory bronchiole +is_a: UBERON:0002188 ! respiratory bronchiole +is_a: UBERON:0003538 ! right lung bronchiole +intersection_of: UBERON:0002188 ! respiratory bronchiole +intersection_of: part_of UBERON:0002167 ! right lung + +[Term] +id: UBERON:0003543 +name: left lung respiratory bronchiole +is_a: UBERON:0002188 ! respiratory bronchiole +is_a: UBERON:0003539 ! left lung bronchiole +intersection_of: UBERON:0002188 ! respiratory bronchiole +intersection_of: part_of UBERON:0002168 ! left lung + [Term] id: UBERON:0003544 name: brain white matter @@ -250883,9 +358051,99 @@ xref: UMLS:C1706994 {source="ncithesaurus:Brain_Pia_Mater"} xref: VHOG:0000470 is_a: UBERON:0002361 ! pia mater is_a: UBERON:0003547 ! brain meninx +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0000955 ! brain property_value: UBPROP:0000001 "The innermost of the three mammalian meninges covering the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000470", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pia+mater"} property_value: UBPROP:0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000470", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0003550 +name: forebrain pia mater +is_a: UBERON:0003548 ! forebrain meninges +is_a: UBERON:0003549 ! brain pia mater +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0001890 ! forebrain + +[Term] +id: UBERON:0003551 +name: midbrain pia mater +is_a: UBERON:0003288 ! meninx of midbrain +is_a: UBERON:0003549 ! brain pia mater +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0001891 ! midbrain + +[Term] +id: UBERON:0003552 +name: telencephalon pia mater +is_a: UBERON:0003289 ! meninx of telencephalon +is_a: UBERON:0003550 ! forebrain pia mater +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0001893 ! telencephalon + +[Term] +id: UBERON:0003553 +name: diencephalon pia mater +is_a: UBERON:0003290 ! meninx of diencephalon +is_a: UBERON:0003550 ! forebrain pia mater +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0001894 ! diencephalon + +[Term] +id: UBERON:0003554 +name: hindbrain pia mater +is_a: UBERON:0003291 ! meninx of hindbrain +is_a: UBERON:0003549 ! brain pia mater +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0002028 ! hindbrain + +[Term] +id: UBERON:0003555 +name: spinal cord pia mater +is_a: UBERON:0002361 ! pia mater +is_a: UBERON:0003292 ! meninx of spinal cord +intersection_of: UBERON:0002361 ! pia mater +intersection_of: part_of UBERON:0002240 ! spinal cord + +[Term] +id: UBERON:0003556 +name: forebrain arachnoid mater +is_a: UBERON:0002362 ! arachnoid mater +is_a: UBERON:0003548 ! forebrain meninges +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0001890 ! forebrain + +[Term] +id: UBERON:0003557 +name: midbrain arachnoid mater +is_a: UBERON:0002362 ! arachnoid mater +is_a: UBERON:0003288 ! meninx of midbrain +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0001891 ! midbrain + +[Term] +id: UBERON:0003558 +name: diencephalon arachnoid mater +is_a: UBERON:0003290 ! meninx of diencephalon +is_a: UBERON:0003556 ! forebrain arachnoid mater +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0001894 ! diencephalon + +[Term] +id: UBERON:0003559 +name: hindbrain arachnoid mater +is_a: UBERON:0002362 ! arachnoid mater +is_a: UBERON:0003291 ! meninx of hindbrain +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0002028 ! hindbrain + +[Term] +id: UBERON:0003560 +name: spinal cord arachnoid mater +is_a: UBERON:0002362 ! arachnoid mater +is_a: UBERON:0003292 ! meninx of spinal cord +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0002240 ! spinal cord + [Term] id: UBERON:0003561 name: forebrain dura mater @@ -251063,6 +358321,8 @@ synonym: "textus connectivus of leg" EXACT [OBOL:automatic] xref: EMAPA:37324 {source="MA:th"} xref: MA:0000671 is_a: UBERON:0003589 ! hindlimb connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0000978 ! leg relationship: part_of UBERON:0000978 ! leg [Term] @@ -251089,6 +358349,32 @@ intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003571 +name: trachea connective tissue +namespace: uberon +def: "A portion of connective tissue that is part of a trachea." [OBOL:automatic] +subset: human_reference_atlas +synonym: "connective tissue of trachea" EXACT [OBOL:automatic] +synonym: "connective tissue of windpipe" EXACT [OBOL:automatic] +xref: EMAPA:35876 +xref: MA:0001853 +is_a: UBERON:0003580 ! lower respiratory tract connective tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0003126 ! trachea +relationship: transformation_of UBERON:0009505 ! mesenchyme of trachea +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003572 +name: chest connective tissue +is_a: UBERON:0003837 ! thoracic segment connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001443 ! chest +relationship: part_of UBERON:0001443 ! chest + [Term] id: UBERON:0003573 name: arm connective tissue @@ -251097,8 +358383,57 @@ def: "A portion of connective tissue that is part of an arm [Automatically gener xref: EMAPA:37316 {source="MA:th"} xref: MA:0000593 is_a: UBERON:0003588 ! forelimb connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001460 ! arm relationship: part_of UBERON:0001460 ! arm +[Term] +id: UBERON:0003574 +name: elbow connective tissue +is_a: UBERON:0003573 ! arm connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001461 ! elbow +relationship: part_of UBERON:0001461 ! elbow +relationship: transformation_of UBERON:0003318 ! mesenchyme of elbow + +[Term] +id: UBERON:0003575 +name: wrist connective tissue +is_a: UBERON:0003598 ! manus connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0004452 ! carpal region +relationship: part_of UBERON:0004452 ! carpal region +relationship: transformation_of UBERON:0003319 ! mesenchyme of carpal region + +[Term] +id: UBERON:0003576 +name: hip connective tissue +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002384 ! connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001464 ! hip +relationship: part_of UBERON:0001464 ! hip +relationship: transformation_of UBERON:0003320 ! mesenchyme of hip + +[Term] +id: UBERON:0003577 +name: knee connective tissue +is_a: UBERON:0003569 ! leg connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001465 ! knee +relationship: part_of UBERON:0001465 ! knee +relationship: transformation_of UBERON:0003321 ! mesenchyme of knee + +[Term] +id: UBERON:0003578 +name: pedal digit connective tissue +is_a: UBERON:0003595 ! pes connective tissue +is_a: UBERON:0015791 ! digit connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: part_of UBERON:0001466 ! pedal digit +relationship: transformation_of UBERON:0005255 ! pedal digit mesenchyme + [Term] id: UBERON:0003579 name: shoulder connective tissue @@ -251113,6 +358448,8 @@ xref: EMAPA:37315 {source="MA:th"} xref: MA:0000632 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002384 ! connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001467 ! shoulder relationship: part_of UBERON:0001467 ! shoulder relationship: transformation_of UBERON:0003322 ! mesenchyme of shoulder @@ -251148,9 +358485,20 @@ xref: NCIT:C49482 xref: UMLS:C1707989 {source="ncithesaurus:Eyelid_Connective_Tissue"} is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid relationship: transformation_of UBERON:0010330 ! eyelid mesenchyme +[Term] +id: UBERON:0003582 +name: nasopharynx connective tissue +is_a: UBERON:0003570 ! respiratory system connective tissue +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx + [Term] id: UBERON:0003583 name: larynx connective tissue @@ -251194,6 +358542,9 @@ xref: FMA:74483 xref: MA:0002897 is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: contributes_to_morphology_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland relationship: transformation_of UBERON:0003326 ! mesenchyme of mammary gland @@ -251299,6 +358650,61 @@ relationship: develops_from UBERON:0003860 ! hindlimb mesenchyme relationship: part_of UBERON:0002103 ! hindlimb relationship: transformation_of UBERON:0003860 ! hindlimb mesenchyme +[Term] +id: UBERON:0003590 +name: main bronchus connective tissue +is_a: UBERON:0003592 ! bronchus connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus +relationship: transformation_of UBERON:0009504 ! mesenchyme of main bronchus + +[Term] +id: UBERON:0003591 +name: lobar bronchus connective tissue +is_a: UBERON:0000114 ! lung connective tissue +is_a: UBERON:0003592 ! bronchus connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus +relationship: transformation_of UBERON:0004884 ! lobar bronchus mesenchyme + +[Term] +id: UBERON:0003592 +name: bronchus connective tissue +namespace: uberon +def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas +synonym: "bronchi connective tissue" EXACT [OBOL:automatic] +synonym: "bronchi portion of connective tissue" EXACT [OBOL:automatic] +synonym: "bronchi textus connectivus" EXACT [OBOL:automatic] +synonym: "bronchial connective tissue" RELATED [EMAPA:35193] +synonym: "bronchial mesenchyme" RELATED [EMAPA:32690] +synonym: "bronchial trunk connective tissue" EXACT [OBOL:automatic] +synonym: "bronchial trunk portion of connective tissue" EXACT [OBOL:automatic] +synonym: "bronchial trunk textus connectivus" EXACT [OBOL:automatic] +synonym: "bronchus portion of connective tissue" EXACT [OBOL:automatic] +synonym: "bronchus textus connectivus" EXACT [OBOL:automatic] +synonym: "connective tissue of bronchi" EXACT [OBOL:automatic] +synonym: "connective tissue of bronchial trunk" EXACT [OBOL:automatic] +synonym: "connective tissue of bronchus" EXACT [OBOL:automatic] +synonym: "portion of connective tissue of bronchi" EXACT [OBOL:automatic] +synonym: "portion of connective tissue of bronchial trunk" EXACT [OBOL:automatic] +synonym: "portion of connective tissue of bronchus" EXACT [OBOL:automatic] +synonym: "textus connectivus of bronchi" EXACT [OBOL:automatic] +synonym: "textus connectivus of bronchial trunk" EXACT [OBOL:automatic] +synonym: "textus connectivus of bronchus" EXACT [OBOL:automatic] +xref: EMAPA:32690 +xref: EMAPA:35193 +xref: MA:0001831 +xref: NCIT:C49210 +xref: UMLS:C1707052 {source="ncithesaurus:Bronchus_Connective_Tissue"} +is_a: UBERON:0003580 ! lower respiratory tract connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0003593 name: thoracic cavity connective tissue @@ -251335,7 +358741,6 @@ synonym: "thoracic cavity portion of connective tissue" EXACT [OBOL:automatic] synonym: "thoracic cavity textus connectivus" EXACT [OBOL:automatic] xref: EMAPA:37255 {source="MA:th"} xref: MA:0000555 -is_a: BFO:0000040 ! material entity is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: located_in UBERON:0002224 ! thoracic cavity @@ -251358,6 +358763,54 @@ intersection_of: UBERON:0002384 ! connective tissue intersection_of: part_of UBERON:0002355 ! pelvic region of trunk relationship: part_of UBERON:0002355 ! pelvic region of trunk +[Term] +id: UBERON:0003595 +name: pes connective tissue +is_a: UBERON:0003589 ! hindlimb connective tissue +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes +relationship: transformation_of UBERON:0003328 ! mesenchyme of footplate + +[Term] +id: UBERON:0003596 +name: ankle connective tissue +is_a: UBERON:0003595 ! pes connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0004454 ! tarsal region +relationship: part_of UBERON:0004454 ! tarsal region +relationship: transformation_of UBERON:0010695 ! mesenchyme of tarsal region + +[Term] +id: UBERON:0003597 +name: manual digit connective tissue +is_a: UBERON:0003598 ! manus connective tissue +is_a: UBERON:0015791 ! digit connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: part_of UBERON:0002389 ! manual digit +relationship: transformation_of UBERON:0005257 ! manual digit mesenchyme + +[Term] +id: UBERON:0003598 +name: manus connective tissue +is_a: UBERON:0003588 ! forelimb connective tissue +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002398 ! manus +relationship: part_of UBERON:0002398 ! manus +relationship: transformation_of UBERON:0009523 ! mesenchyme of handplate + +[Term] +id: UBERON:0003599 +name: tail connective tissue +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002384 ! connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0003601 name: neck cartilage @@ -251394,6 +358847,7 @@ id: UBERON:0003604 name: trachea cartilage namespace: uberon def: "The ring-shaped cartilaginous structures that support the trachea." [http://orcid.org/0000-0002-6601-2165, J:97123, MGI:smb, MP:0003120] +subset: human_reference_atlas subset: pheno_slim synonym: "cartilage of the trachea" RELATED [Wikipedia:Tracheal_rings] synonym: "cartilage of trachea" EXACT [OBOL:automatic] @@ -251417,10 +358871,13 @@ xref: UMLS:C1710456 {source="ncithesaurus:Trachea_Cartilage"} xref: Wikipedia:Tracheal_rings is_a: UBERON:0003603 ! lower respiratory tract cartilage is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0007267 ! trachea pre-cartilage rings relationship: part_of UBERON:0003126 ! trachea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png xsd:anyURI property_value: editor_note "check whether to classify as part of splanchoncranium" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "in mammals the rings are incomplete, in avians the rings are complete." xsd:string [Term] @@ -251461,6 +358918,8 @@ xref: EMAPA:35495 xref: MA:0000298 is_a: UBERON:0002428 ! limb bone is_a: UBERON:0002495 ! long bone +intersection_of: UBERON:0002495 ! long bone +intersection_of: part_of UBERON:0002101 ! limb [Term] id: UBERON:0003607 @@ -251481,6 +358940,8 @@ xref: EMAPA:35350 xref: MA:0000299 is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0008962 ! forelimb bone +intersection_of: UBERON:0002495 ! long bone +intersection_of: part_of UBERON:0002102 ! forelimb [Term] id: UBERON:0003608 @@ -251498,6 +358959,8 @@ xref: EMAPA:35403 xref: MA:0000300 is_a: UBERON:0003464 ! hindlimb bone is_a: UBERON:0003606 ! limb long bone +intersection_of: UBERON:0002495 ! long bone +intersection_of: part_of UBERON:0002103 ! hindlimb [Term] id: UBERON:0003609 @@ -251643,6 +359106,67 @@ is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: part_of UBERON:0002048 ! lung +[Term] +id: UBERON:0003616 +name: bronchus elastic tissue +namespace: uberon +def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchi elastic connective tissue" EXACT [OBOL:automatic] +synonym: "bronchi elastic tissue" EXACT [OBOL:automatic] +synonym: "bronchi textus connectivus elasticus" EXACT [OBOL:automatic] +synonym: "bronchial trunk elastic connective tissue" EXACT [OBOL:automatic] +synonym: "bronchial trunk elastic tissue" EXACT [OBOL:automatic] +synonym: "bronchial trunk textus connectivus elasticus" EXACT [OBOL:automatic] +synonym: "bronchus elastic connective tissue" EXACT [OBOL:automatic] +synonym: "bronchus textus connectivus elasticus" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of bronchi" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of bronchial trunk" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of bronchus" EXACT [OBOL:automatic] +synonym: "elastic tissue of bronchi" EXACT [OBOL:automatic] +synonym: "elastic tissue of bronchial trunk" EXACT [OBOL:automatic] +synonym: "elastic tissue of bronchus" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of bronchi" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of bronchial trunk" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of bronchus" EXACT [OBOL:automatic] +xref: MA:0001838 +xref: NCIT:C49211 +xref: UMLS:C1707053 {source="ncithesaurus:Bronchus_Elastic_Tissue"} +is_a: UBERON:0003592 ! bronchus connective tissue +is_a: UBERON:0003611 ! respiratory system elastic tissue +intersection_of: UBERON:0002521 ! elastic tissue +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0001957 ! submucosa of bronchus + +[Term] +id: UBERON:0003617 +name: trachea elastic tissue +namespace: uberon +def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +synonym: "cartilaginous trachea elastic connective tissue" EXACT [OBOL:automatic] +synonym: "cartilaginous trachea elastic tissue" EXACT [OBOL:automatic] +synonym: "cartilaginous trachea textus connectivus elasticus" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of cartilaginous trachea" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of vertebrate trachea" EXACT [OBOL:automatic] +synonym: "elastic connective tissue of windpipe" EXACT [OBOL:automatic] +synonym: "elastic tissue of cartilaginous trachea" EXACT [OBOL:automatic] +synonym: "elastic tissue of vertebrate trachea" EXACT [OBOL:automatic] +synonym: "elastic tissue of windpipe" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of cartilaginous trachea" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of vertebrate trachea" EXACT [OBOL:automatic] +synonym: "textus connectivus elasticus of windpipe" EXACT [OBOL:automatic] +synonym: "vertebrate trachea elastic connective tissue" EXACT [OBOL:automatic] +synonym: "vertebrate trachea elastic tissue" EXACT [OBOL:automatic] +synonym: "vertebrate trachea textus connectivus elasticus" EXACT [OBOL:automatic] +synonym: "windpipe elastic connective tissue" EXACT [OBOL:automatic] +synonym: "windpipe elastic tissue" EXACT [OBOL:automatic] +synonym: "windpipe textus connectivus elasticus" EXACT [OBOL:automatic] +xref: MA:0001861 +is_a: UBERON:0003571 ! trachea connective tissue +is_a: UBERON:0003611 ! respiratory system elastic tissue +intersection_of: UBERON:0002521 ! elastic tissue +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0002202 ! submucosa of trachea + [Term] id: UBERON:0003618 name: aorta tunica media @@ -251712,6 +359236,8 @@ xref: SCTID:181975002 xref: UMLS:C1711344 {source="ncithesaurus:Hand_Digit_1_Phalanx"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0015025 ! manual digit 1 phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0001463 ! manual digit 1 relationship: develops_from UBERON:0010675 ! manual digit 1 phalanx cartilage element [Term] @@ -251744,7 +359270,7 @@ xref: Wikipedia:Index_finger is_a: UBERON:0006049 ! digit 2 is_a: UBERON:0019232 ! manual digit 2, 3 or 4 relationship: part_of UBERON:5003622 ! manual digit 2 plus metapodial segment -property_value: depicted:by Index:finger.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/d5/Index_finger.JPG xsd:anyURI property_value: RO:0002173 NCBITaxon:8782 property_value: UBPROP:0000007 "indicis" xsd:string property_value: UBPROP:0000008 "Anurans lack manual digit 1, so manual digit 2 is the digit after the prepollex (Phenotype RCN Oct 2012)" xsd:string @@ -251782,7 +359308,7 @@ xref: Wikipedia:Middle_finger is_a: UBERON:0006050 ! digit 3 is_a: UBERON:0019232 ! manual digit 2, 3 or 4 relationship: part_of UBERON:5003623 ! manual digit 3 plus metapodial segment -property_value: depicted:by Middle:finger.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/f/fd/Middle_finger.jpg xsd:anyURI property_value: RO:0002173 NCBITaxon:8782 property_value: UBPROP:0000008 "This class represents the standard tetrapod configuration. Wagner proposes that avian digits I,II,III develop from C2,C3,C4. To support this scheme we have separate classes representing the avian digits (here called alula, manual digit, major digit)." xsd:string {scope="NCBITaxon:8782", seeAlso="UBERON:0012262", source="PMID:10220427", source="PhenoscapeRCN"} @@ -251817,7 +359343,7 @@ xref: Wikipedia:Ring_finger is_a: UBERON:0006051 ! digit 4 is_a: UBERON:0019232 ! manual digit 2, 3 or 4 relationship: part_of UBERON:5003624 ! manual digit 4 plus metapodial segment -property_value: depicted:by Ring:finger.JPG xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/1/14/Ring_finger.JPG xsd:anyURI property_value: RO:0002173 NCBITaxon:8782 [Term] @@ -251853,6 +359379,8 @@ xref: UMLS:C0230403 {source="ncithesaurus:Hand_Digit_5"} xref: Wikipedia:Little_finger is_a: UBERON:0006052 ! digit 5 is_a: UBERON:0019231 ! manual digit 1 or 5 +intersection_of: UBERON:0006052 ! digit 5 +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:5003625 ! manual digit 5 plus metapodial segment property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ed/Pink.jpg xsd:anyURI @@ -251900,6 +359428,9 @@ xref: VSAO:0000201 xref: Wikipedia:Hallux is_a: UBERON:0006048 ! digit 1 is_a: UBERON:0019241 ! pedal digit 1 or 5 +intersection_of: UBERON:0006048 ! digit 1 +intersection_of: part_of UBERON:0002387 ! pes +relationship: BSPO:0001113 UBERON:0002387 ! pes relationship: part_of UBERON:5003631 ! pedal digit 1 plus metapodial segment property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ab/RightFootToes.jpg xsd:anyURI @@ -252045,6 +359576,8 @@ xref: UMLS:C1708087 {source="ncithesaurus:Foot_Digit_5"} xref: Wikipedia:Fifth_toe is_a: UBERON:0006052 ! digit 5 is_a: UBERON:0019241 ! pedal digit 1 or 5 +intersection_of: UBERON:0006052 ! digit 5 +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:5003635 ! pedal digit 5 plus metapodial segment property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png xsd:anyURI @@ -252230,6 +359763,8 @@ xref: SCTID:361789008 xref: UMLS:C1708317 {source="ncithesaurus:Hand_Digit_5_Phalanx"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0015029 ! manual digit 5 phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0003625 ! manual digit 5 relationship: develops_from UBERON:0010679 ! manual digit 5 phalanx cartilage element [Term] @@ -252266,6 +359801,8 @@ xref: SCTID:361798006 xref: UMLS:C1708080 {source="ncithesaurus:Foot_Digit_1_Phalanx"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0015031 ! pedal digit 1 phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0003631 ! pedal digit 1 relationship: develops_from UBERON:0010680 ! pedal digit 1 phalanx cartilage element [Term] @@ -252384,6 +359921,8 @@ xref: UMLS:C1708987 {source="ncithesaurus:Metacarpal_Bone_Digit_1"} is_a: UBERON:0002374 ! metacarpal bone is_a: UBERON:0013581 ! metapodium bone 1 is_a: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010570 ! manual digit 1 metacarpus cartilage element property_value: UBPROP:0000001 "The first metacarpal bone or the metacarpal bone of the thumb is the first bone of the thumb. It is connected to the trapezium of the carpus at the first carpometacarpal joint and to the proximal thumb phalanx at the first metacarpophalangeal joint[Wikipedia:First_metacarpal_bone]." xsd:string {source="Wikipedia:First_metacarpal_bone"} property_value: UBPROP:0000104 "1" xsd:nonNegativeInteger @@ -252563,6 +360102,8 @@ xref: UMLS:C1711224 {source="ncithesaurus:Metacarpal_Bone_Digit_5"} is_a: UBERON:0002374 ! metacarpal bone is_a: UBERON:0013585 ! metapodium bone 5 is_a: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010574 ! manual digit 5 metacarpus cartilage element property_value: UBPROP:0000001 "Dumb-bell shaped bones of endochondral origin with cartilaginous epiphyses that articulates with carpal 5(4) proximally and with the proximal phalanx of digit V(IV) distally.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000855", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "The fifth metacarpal bone (metacarpal bone of the little finger or pinky finger) is the most lateral metacarpal[Wikipedia:Fifth_metacarpal_bone]." xsd:string {source="Wikipedia:Fifth_metacarpal_bone"} @@ -252597,7 +360138,10 @@ xref: UMLS:C1708999 {source="ncithesaurus:Metatarsal_Bone_Digit_1"} is_a: UBERON:0001448 ! metatarsal bone is_a: UBERON:0013581 ! metapodium bone 1 is_a: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010557 ! pedal digit 1 metatarsal cartilage element +relationship: distally_connected_to UBERON:0004332 ! proximal phalanx of pedal digit 1 property_value: UBPROP:0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with the prepollex and tarsal 1 proximally and with the proximal phalanx of digit I distally.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000925", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "The first metatarsal bone is the bone in the body of the foot just behind the big toe. It is remarkable for its great thickness, and is the shortest of the metatarsal bones. The body is strong, and of well-marked prismoid form. The base presents, as a rule, no articular facets on its sides, but occasionally on the lateral side there is an oval facet, by which it articulates with the second metatarsal. Its proximal articular surface is of large size and kidney-shaped; its circumference is grooved, for the tarsometatarsal ligaments, and medially gives insertion to part of the tendon of the Tibialis anterior; its plantar angle presents a rough oval prominence for the insertion of the tendon of the Peronæus longus. The head is large; on its plantar surface are two grooved facets, on which glide sesamoid bones; the facets are separated by a smooth elevation[Wikipedia:First_metatarsal_bone]." xsd:string {source="Wikipedia:First_metatarsal_bone"} property_value: UBPROP:0000104 "1" xsd:nonNegativeInteger @@ -252722,7 +360266,10 @@ xref: UMLS:C1709003 {source="ncithesaurus:Metatarsal_Bone_Digit_5"} is_a: UBERON:0001448 ! metatarsal bone is_a: UBERON:0013585 ! metapodium bone 5 is_a: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0010561 ! pedal digit 5 metatarsal cartilage element +relationship: distally_connected_to UBERON:0004336 ! proximal phalanx of pedal digit 5 property_value: UBPROP:0000001 "Dumb-bell-shaped bone of endochondral origin with cartilaginous epiphyses that articulates with tarsal 5 or the distal head of the tibiale-fibulare proximally and with the proximal phalanx of digit V distally.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000929", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "The fifth metatarsal bone is recognized by a rough eminence, the tuberosity, on the lateral side of its base. The base articulates behind, by a triangular surface cut obliquely in a transverse direction, with the cuboid; and medially, with the fourth metatarsal. On the medial part of its dorsal surface is inserted the tendon of the Peronæus tertius and on the dorsal surface of the tuberosity that of the Peronæus brevis. A strong band of the plantar aponeurosis connects the projecting part of the tuberosity with the lateral process of the tuberosity of the calcaneus. The plantar surface of the base is grooved for the tendon of the Abductor digiti quinti, and gives origin to the Flexor digiti quinti brevis. The base of the metatarsal is often injured and a particularly notorious fracture is the Jones fracture. When the tuberosity is broken, it is called a pseudo-Jones fracture or a dancer's fracture. This is a common fracture of the fifth metatarsal. Stress fractures are common in the fifth metatarsal among athletes[Wikipedia:Fifth_metatarsal_bone]." xsd:string {source="Wikipedia:Fifth_metatarsal_bone"} property_value: UBPROP:0000104 "5" xsd:nonNegativeInteger @@ -252741,7 +360288,7 @@ xref: CALOHA:TS-0637 xref: EMAPA:32897 xref: FMA:55638 xref: MA:0000350 -xref: MESH:A14.254.860.525 +xref: MESH:D008963 xref: NCIT:C33136 xref: SCTID:362115002 xref: UMLS:C0026367 {source="ncithesaurus:Molar_Tooth"} @@ -252763,6 +360310,8 @@ xref: MA:0000295 xref: Wikipedia:Carpus_and_tarsus_of_land_vertebrates is_a: UBERON:0011250 ! autopod bone is_a: UBERON:0013630 {source="UBERON:cjm"} ! short bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0006716 ! mesopodium region relationship: part_of UBERON:0009878 {notes="https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"} ! mesopodial skeleton property_value: UBPROP:0000008 "The carpus (wrist) and tarsus (ankle) of land vertebrates primitively had three rows of carpal or tarsal bones. Often some of these have become lost or fused in evolution. Three proximals. In the hand humans has all three. In the foot the middle proximal appears in 5-15% of people as an os trigonum. Centrale or os centrale, on the medial side. In humans and our closest relatives the African apes (chimpanzees and gorillas) it fuses to the scaphoid where it forms the articulation with the trapezoid bone; occasionally it stays separate. In Man's foot it is the navicular. Some early land vertebrates had more than one (up to three) os centrale per hand or foot. Distals, one per finger / toe at the base of each metacarpal or metatarsal. In mammals the 4th and 5th fuse. In the horse the 1st is lost" xsd:string {source="Wikipedia:Carpus_and_tarsus_of_land_vertebrates"} @@ -252788,6 +360337,23 @@ intersection_of: UBERON:0000982 ! skeletal joint intersection_of: part_of UBERON:0002101 ! limb relationship: part_of UBERON:0002101 ! limb +[Term] +id: UBERON:0003658 +name: hip muscle +is_a: UBERON:0010890 ! pelvic complex muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001464 ! hip +relationship: part_of UBERON:0001464 ! hip +relationship: part_of UBERON:0004475 ! musculature of hip + +[Term] +id: UBERON:0003659 +name: pedal digit muscle +is_a: UBERON:0001498 ! muscle of pes +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: part_of UBERON:0001466 ! pedal digit + [Term] id: UBERON:0003660 name: eyelid muscle @@ -252800,7 +360366,11 @@ synonym: "muscle organ of eyelid" EXACT [OBOL:automatic] xref: MA:0000269 xref: NCIT:C52803 xref: UMLS:C1707990 {source="ncithesaurus:Eyelid_Muscle"} +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001630 ! muscle organ +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: attaches_to UBERON:0001711 ! eyelid +relationship: attaches_to UBERON:0001711 ! eyelid property_value: UBPROP:0000001 "The muscle in the orbit of the eye that lifts the upper eyelid[ncithesaurus:Eyelid_Muscle]." xsd:string {source="ncithesaurus:Eyelid_Muscle"} [Term] @@ -252815,6 +360385,9 @@ synonym: "muscle organ of limb" EXACT [OBOL:accepted] xref: EMAPA:32700 xref: MA:0000692 is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002101 ! limb +relationship: contributes_to_morphology_of UBERON:0001015 ! musculature relationship: part_of UBERON:0004480 {source="prolog"} ! musculature of limb [Term] @@ -252840,6 +360413,8 @@ xref: EMAPA:36049 xref: FMA:37348 is_a: UBERON:0003661 ! limb muscle is_a: UBERON:0014794 ! pectoral appendage muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002102 ! forelimb relationship: part_of UBERON:0004481 {source="prolog"} ! musculature of upper limb property_value: UBPROP:0000012 "FMA and MA class actually refer to muscles of entire pectoral complex" xsd:string {external_ontology="FMA"} @@ -252866,8 +360441,27 @@ xref: EFO:0001928 xref: FMA:37368 is_a: UBERON:0003661 ! limb muscle is_a: UBERON:0014795 ! pelvic appendage muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002103 ! hindlimb relationship: part_of UBERON:0004482 {source="prolog"} ! musculature of lower limb +[Term] +id: UBERON:0003664 +name: manual digit muscle +is_a: UBERON:0001500 ! muscle of manus +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: part_of UBERON:0002389 ! manual digit + +[Term] +id: UBERON:0003665 +name: post-anal tail muscle +is_a: UBERON:0004518 ! muscle of vertebral column +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0001095 ! caudal vertebra +relationship: attaches_to UBERON:0001095 ! caudal vertebra +relationship: overlaps UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0003672 name: dentition @@ -252883,14 +360477,18 @@ synonym: "teeth set" EXACT [FMA:75150] xref: AAO:0000126 xref: FMA:75150 xref: GAID:1249 -xref: MESH:A14.254 +xref: MESH:D003817 xref: NCIT:C13072 xref: OpenCyc:Mx4rvVi65JwpEbGdrcN5Y29ycA xref: SCTID:245543004 xref: UMLS:C0011443 {source="ncithesaurus:Dentition"} -is_a: BFO:0000004 ! independent continuant +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034925 ! anatomical collection +intersection_of: UBERON:0034925 ! anatomical collection +intersection_of: has_member UBERON:0001091 ! calcareous tooth +relationship: has_member UBERON:0001091 ! calcareous tooth relationship: part_of UBERON:0010323 ! cranial skeletal system +relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! jaw region property_value: UBPROP:0000001 "Dentition refers to set of teeth, especially with regard to their number, kind, and arrangement, in the mouth.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000126", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000001 "The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. (MeSH[ncithesaurus:Dentition])" xsd:string {source="ncithesaurus:Dentition"} property_value: UBPROP:0000012 "In FMA this is an anatomical set" xsd:string {external_ontology="FMA"} @@ -252919,14 +360517,14 @@ synonym: "eyetooth" RELATED [Wikipedia:Canine_tooth] synonym: "fang" RELATED [Wikipedia:Canine_tooth] xref: FMA:55636 xref: GAID:1262 -xref: MESH:A14.254.860.200 +xref: MESH:D003481 xref: NCIT:C32258 xref: SCTID:420817000 xref: SCTID:88719004 xref: UMLS:C0010482 {source="ncithesaurus:Canine_Tooth"} xref: Wikipedia:Canine_tooth is_a: UBERON:0001091 ! calcareous tooth -property_value: depicted:by Azawakh:K9.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/57/Azawakh_K9.jpg xsd:anyURI property_value: RO:0002161 NCBITaxon:337687 {notes="Although there are a few exceptions, the dental formula for the great majority of cricetids is 1.0.0.3", source="Wikipedia:Cricetidae"} property_value: UBPROP:0000008 "Most species that develop them normally have four per individual, two in the upper jaw and two in the lower, separated within each jaw by its incisors; humans and dogs are examples. In most animals, canines are the anterior-most teeth in the maxillary bone. The four canines in humans are the two maxillary canines and the two mandibular canines." xsd:string @@ -252942,7 +360540,7 @@ synonym: "crown of tooth" EXACT [FMA:55623] synonym: "tooth crown" EXACT [FMA:55623] xref: FMA:55623 xref: GAID:1275 -xref: MESH:A14.254.900.710 +xref: MESH:D019228 xref: NCIT:C32375 xref: SCTID:362106009 xref: UMLS:C0226993 {source="ncithesaurus:Corona_Dentis"} @@ -252963,7 +360561,7 @@ synonym: "tooth root" EXACT [FMA:55624] xref: EMAPA:37975 {source="MA:th"} xref: FMA:55624 xref: GAID:1280 -xref: MESH:A14.254.900.750 +xref: MESH:D014092 xref: SCTID:245728004 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure @@ -253042,6 +360640,8 @@ xref: Wikipedia:Muscles_of_soft_palate_and_fauces is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010959 ! craniocervical muscle is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001733 ! soft palate relationship: part_of UBERON:0001733 ! soft palate property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray1028.png xsd:anyURI property_value: editor_note "consider extra class for fauces" xsd:string @@ -253069,6 +360669,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0230168 xref: http://www.snomedbrowser.com/Codes/Details/361294009 xref: MA:0003057 xref: MESH:A01.047.025 +xref: MESH:D034841 xref: NCIT:C12664 xref: OpenCyc:Mx4rvZR1TJwpEbGdrcN5Y29ycA xref: SCTID:361294009 @@ -253105,6 +360706,7 @@ xref: MA:0001475 xref: MESH:D003393 xref: SCTID:244509003 xref: Wikipedia:Suture_(joint) +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0009198 {source="GO"} ! craniofacial suture intersection_of: UBERON:0002209 ! fibrous joint intersection_of: part_of UBERON:0003128 ! cranium @@ -253137,7 +360739,6 @@ xref: TAO:0002045 xref: UMLS:C0016519 {source="ncithesaurus:Foramen_Magnum"} xref: Wikipedia:Foramen_magnum xref: ZFA:0005387 -is_a: BFO:0000040 ! material entity is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: conduit_for UBERON:0001896 ! medulla oblongata @@ -253156,7 +360757,7 @@ xref: EV:0100084 xref: FMA:14650 xref: GAID:23 xref: galen:Omentum -xref: MESH:A01.047.025.600.573 +xref: MESH:D009852 xref: NCIT:C33209 xref: SCTID:362710002 xref: UMLS:C0028977 {source="ncithesaurus:Omentum"} @@ -253193,11 +360794,25 @@ is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0006075 ! sacral region of vertebral column is_a: UBERON:0008001 {source="FMA"} ! irregular bone +intersection_of: UBERON:0006075 ! sacral region of vertebral column +intersection_of: part_of UBERON:0001270 ! bony pelvis +intersection_of: RO:0002374 UBERON:0001094 ! derived from ancestral fusion of sacral vertebra relationship: part_of UBERON:0001270 {source="FMA"} ! bony pelvis +relationship: RO:0002374 UBERON:0001094 ! derived from ancestral fusion of sacral vertebra property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray95.png xsd:anyURI property_value: UBPROP:0000007 "sacral" xsd:string property_value: UBPROP:0000012 "the AAO class 'sacrum' is deliberately placed under 'sacral vertebra' rather than here" xsd:string {external_ontology="AAO"} +[Term] +id: UBERON:0003691 +name: epidural space +is_a: UBERON:0010276 ! space in vertebral column +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0006692 ! vertebral canal +intersection_of: surrounds UBERON:0002363 ! dura mater +relationship: part_of UBERON:0006692 ! vertebral canal +relationship: surrounds UBERON:0002363 ! dura mater + [Term] id: UBERON:0003692 name: acromioclavicular joint @@ -253216,9 +360831,21 @@ xref: UMLS:C0001208 {source="ncithesaurus:Acromioclavicular_Joint"} xref: Wikipedia:Acromioclavicular_joint is_a: UBERON:0011108 {source="FMA"} ! synovial joint of pectoral girdle is_a: UBERON:0016884 ! shoulder joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001105 ! clavicle bone +intersection_of: connects UBERON:0002497 ! acromion +relationship: connects UBERON:0001105 ! clavicle bone +relationship: connects UBERON:0002497 ! acromion property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3b/Gray326.png xsd:anyURI property_value: UBPROP:0000001 "The gliding joint formed by the outer extremity of the clavicle and the inner margin of the acromion process of the scapula." xsd:string {source="MESH:A02.835.583.032"} +[Term] +id: UBERON:0003693 +name: retroperitoneal space +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +relationship: part_of UBERON:0003684 ! abdominal cavity + [Term] id: UBERON:0003695 name: metacarpophalangeal joint @@ -253238,7 +360865,7 @@ xref: FMA:35246 xref: GAID:255 xref: galen:MetacarpoPhalangealJoint xref: MA:0000453 -xref: MESH:A02.835.583.345.512 +xref: MESH:D008662 xref: NCIT:C33106 xref: OpenCyc:Mx4rwNt8wJwpEbGdrcN5Y29ycA xref: SCTID:280995004 @@ -253246,11 +360873,27 @@ xref: SCTID:370651001 xref: UMLS:C0025525 {source="ncithesaurus:Metacarpophalangeal_Joint"} xref: Wikipedia:Metacarpophalangeal_joint is_a: UBERON:0001489 ! manus joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002234 ! proximal phalanx of manus +intersection_of: connects UBERON:0002374 ! metacarpal bone +relationship: connects UBERON:0002234 ! proximal phalanx of manus +relationship: connects UBERON:0002374 ! metacarpal bone relationship: part_of UBERON:0002389 ! manual digit property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/53/Gray337.png xsd:anyURI property_value: editor_note "we follow FMA in making these joints part of digits. We include carpometacarpophalangeal joint as a synonym - these joints connect to the carpometacarpus - this is not necessarily inconsistent with the relationship for this class to metacarpal bone, as the carpometacarpus could be considered to have a metacarpal as part" xsd:string property_value: UBPROP:0000202 FMA:71364 +[Term] +id: UBERON:0003696 +name: metatarsophalangeal joint +is_a: UBERON:0001487 ! pes joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001448 ! metatarsal bone +intersection_of: connects UBERON:0003867 ! distal phalanx of pes +relationship: connects UBERON:0001448 ! metatarsal bone +relationship: connects UBERON:0003867 ! distal phalanx of pes +relationship: part_of UBERON:0001466 ! pedal digit + [Term] id: UBERON:0003697 name: abdominal wall @@ -253274,6 +360917,7 @@ xref: GAID:26 xref: http://linkedlifedata.com/resource/umls/id/C0836916 xref: http://www.snomedbrowser.com/Codes/Details/181613000 xref: MESH:A01.047.050 +xref: MESH:D034861 xref: NCIT:C77608 xref: SCTID:181613000 xref: UMLS:C0836916 {source="ncithesaurus:Abdominal_Wall"} @@ -253374,6 +361018,10 @@ xref: Wikipedia:Achilles_tendon is_a: UBERON:0000043 {source="MA"} ! tendon is_a: UBERON:0004270 ! lower leg connective tissue is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: connects UBERON:0001450 ! calcaneus +relationship: connects UBERON:0001383 ! muscle of leg +relationship: connects UBERON:0001450 ! calcaneus relationship: part_of UBERON:0001665 {source="FMA"} ! triceps surae property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg xsd:anyURI property_value: UBPROP:0000008 "reduced in non-human primates" xsd:string @@ -253391,7 +361039,7 @@ xref: BTO:0005576 xref: EMAPA:37881 {source="MA:th"} xref: FMA:19928 xref: GAID:28 -xref: MESH:A01.047.412 +xref: MESH:D007264 xref: NCIT:C93029 xref: SCTID:243966008 xref: UMLS:C0021445 {source="ncithesaurus:Inguinal_Canal"} @@ -253441,6 +361089,9 @@ xref: TAO:0005169 xref: UMLS:C0005401 {source="ncithesaurus:Intrahepatic_Bile_Duct"} xref: ZFA:0005169 is_a: UBERON:0002394 {source="FMA"} ! bile duct +intersection_of: UBERON:0002394 ! bile duct +intersection_of: part_of UBERON:0002107 ! liver +relationship: contributes_to_morphology_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 {source="MA"} ! liver property_value: editor_note "includes the hepatic duct of the caudate lobe, and the intra- and inter- lobar bile ducts" xsd:string property_value: UBPROP:0000001 "Duct that collects bile from the bile ductules and connects to the extrahepatic bile duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005169", ontology="TAO", source="ZFIN:curator"} @@ -253468,6 +361119,7 @@ xref: SCTID:245504003 xref: UMLS:C0042930 {source="ncithesaurus:Vocal_Cord"} is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0034681 ! vocal organ +relationship: in_lateral_side_of UBERON:0002486 ! glottis relationship: part_of UBERON:0002486 {source="BTO", source="FMA-abduced"} ! glottis property_value: editor_note "we follow FMA in modeling this is mucous membrane plus ligament" xsd:string @@ -253498,6 +361150,7 @@ xref: Wikipedia:Aortic_sinus is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0010172 ! bulb of aorta relationship: part_of UBERON:0010172 {source="FMA", source="MP"} ! bulb of aorta property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/54/Gray497.png xsd:anyURI @@ -253517,8 +361170,8 @@ xref: EHDAA:9758 xref: EMAPA:37829 {source="MA:th"} xref: FMA:50454 xref: GAID:486 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1468 xref: MESH:D002941 +xref: neuronames:1468 xref: OpenCyc:Mx4rwSrCwJwpEbGdrcN5Y29ycA xref: SCTID:362047009 xref: Wikipedia:Circle_of_Willis @@ -253528,12 +361181,48 @@ relationship: overlaps UBERON:0007143 {source="FMA-modified"} ! right internal c property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg xsd:anyURI property_value: UBPROP:0000008 "In zebrafish, the circle of vessels comprised of the basal communicating artery (BCA) and posterior communicating segments (PCS) superficially resemble but are not homologous to the human circle of Willis" xsd:string {source="http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html"} +[Term] +id: UBERON:0003711 +name: brachiocephalic vein +namespace: uberon +def: "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." [Wikipedia:Brachiocephalic_vein] +subset: human_reference_atlas +synonym: "brachiocephalic venous tree" EXACT [FMA:4723] +synonym: "innomiate vein" RELATED [Wikipedia:Brachiocephalic_vein] +synonym: "innominate trunk" RELATED [Wikipedia:Brachiocephalic_vein] +synonym: "innominate vein" EXACT [FMA:4723] +synonym: "innominate vein" RELATED [GAID:529] +synonym: "innominate vein" RELATED [Wikipedia:Brachiocephalic_vein] +synonym: "innominate veins" RELATED [Wikipedia:Brachiocephalic_vein] +synonym: "vena brachiocephalica" RELATED [Wikipedia:Brachiocephalic_vein] +synonym: "vena brachiocephalica" RELATED LATIN [Wikipedia:Brachiocephalic_vein] +synonym: "venae anonyma" RELATED LATIN [Wikipedia:Brachiocephalic_vein] +xref: EHDAA2:0000182 +xref: EHDAA:9868 +xref: FMA:4723 +xref: GAID:529 +xref: galen:BrachiocephalicVein +xref: MESH:D016121 +xref: NCIT:C32816 +xref: OpenCyc:Mx4rvz3aUJwpEbGdrcN5Y29ycA +xref: SCTID:181371003 +xref: UMLS:C0006095 {source="ncithesaurus:Innominate_Vein"} +xref: Wikipedia:Brachiocephalic_vein +is_a: UBERON:0001638 ! vein +relationship: connected_to UBERON:0001585 ! anterior vena cava +relationship: part_of UBERON:0007204 ! brachiocephalic vasculature +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0003713 name: splenic vein namespace: uberon def: "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." [ncithesaurus:Splenic_Vein] +subset: human_reference_atlas synonym: "lienal vein" RELATED [http://en.wikipedia.org/wiki/Splenic_vein, MA:0002164] +synonym: "lienal vein" RELATED [MA:0002164, Wikipedia:Splenic_vein] +synonym: "vena lienalis" RELATED LATIN [Wikipedia:Splenic_vein] synonym: "vena lienalis" RELATED LATIN [http://en.wikipedia.org/wiki/Splenic_vein] synonym: "vena splenica" EXACT LATIN [FMA:14331, FMA:TA] xref: EMAPA:37226 {source="MA:th"} @@ -253546,11 +361235,15 @@ xref: MA:0002164 xref: MESH:D013162 xref: NCIT:C33608 xref: OpenCyc:Mx4rwCt0eZwpEbGdrcN5Y29ycA +xref: SCTID:278029005 xref: Splenic:vein xref: UMLS:C0038001 {source="ncithesaurus:Splenic_Vein"} +xref: Wikipedia:Splenic_vein is_a: UBERON:0001638 ! vein +relationship: connected_to UBERON:0001639 ! hepatic portal vein property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003714 @@ -253572,7 +361265,6 @@ xref: NCIT:C13052 xref: OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ xref: SCTID:91728009 xref: UMLS:C0027757 {source="ncithesaurus:Nervous_Tissue"} -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue @@ -253600,6 +361292,7 @@ xref: GAID:800 xref: MESH:D013153 xref: SCTID:264198001 xref: Wikipedia:Splanchnic_nerves +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0034729 ! sympathetic nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0000916 ! abdomen @@ -253643,7 +361336,7 @@ synonym: "neuromuscular spindle" EXACT [FMA:83607] synonym: "neuromuscular spindle" RELATED [GAID:819] xref: FMA:83607 xref: GAID:819 -xref: MESH:A08.800.550.700.500.500 +xref: MESH:D009470 xref: NCIT:C13824 xref: SCTID:12945004 xref: UMLS:C0027871 {source="ncithesaurus:Muscle_Spindle"} @@ -253677,8 +361370,7 @@ xref: FMA:83604 xref: FMA:83609 xref: GAID:817 xref: GAID:820 -xref: MESH:A08.800.550.700.500.300 -xref: MESH:A08.800.550.700.500.700 +xref: MESH:D010141 xref: NCIT:C13172 xref: NIF_Subcellular:FMA_83604 xref: SCTID:37419002 @@ -253691,6 +361383,11 @@ property_value: UBPROP:0000008 "may also be present in the mesentery of cats, in property_value: UBPROP:0000010 "consists of a nerve fiber, an inner core of modified Schwann cells, a subcapsular space and a capsule [ISBN:9780849388118]" xsd:string property_value: UBPROP:0000012 "FMA treats pacinia and G-M as distinct" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0003720 +name: anterior cranial fossa +is_a: UBERON:0008789 ! cranial fossa + [Term] id: UBERON:0003721 name: lingual nerve @@ -253707,12 +361404,18 @@ xref: MA:0001102 xref: MESH:D008036 xref: SCTID:280260006 xref: Wikipedia:Lingual_nerve +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011779 ! nerve of head region intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0001723 ! tongue relationship: branching_part_of UBERON:0000375 ! mandibular nerve relationship: innervates UBERON:0001723 ! tongue +[Term] +id: UBERON:0003722 +name: middle cranial fossa +is_a: UBERON:0008789 ! cranial fossa + [Term] id: UBERON:0003723 name: vestibular nerve @@ -253734,25 +361437,44 @@ xref: EHDAA:3749 xref: EMAPA:17803 xref: FMA:53401 xref: GAID:840 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1389 xref: MA:0001111 xref: MBA:413 xref: MESH:D014725 xref: NCIT:C12820 +xref: neuronames:1389 xref: OpenCyc:Mx4rvxAWX5wpEbGdrcN5Y29ycA xref: SCTID:362464003 xref: UMLS:C0042598 {source="ncithesaurus:Vestibular_Nerve"} xref: VHOG:0001181 xref: Wikipedia:Vestibular_nerve +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: branching_part_of UBERON:0001648 ! vestibulocochlear nerve +intersection_of: extends_fibers_into UBERON:0007228 ! vestibular nucleus +intersection_of: innervates UBERON:0001840 ! semicircular canal +intersection_of: innervates UBERON:0006585 ! vestibular organ +relationship: branching_part_of UBERON:0001648 ! vestibulocochlear nerve +relationship: extends_fibers_into UBERON:0007228 ! vestibular nucleus +relationship: innervates UBERON:0001840 ! semicircular canal +relationship: innervates UBERON:0006585 ! vestibular organ relationship: part_of UBERON:0004681 ! vestibular system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg xsd:anyURI +[Term] +id: UBERON:0003724 +name: musculocutaneous nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0001021 ! nerve +relationship: branching_part_of UBERON:0001814 ! brachial nerve plexus +relationship: innervates UBERON:0002102 ! forelimb + [Term] id: UBERON:0003725 name: cervical nerve plexus namespace: uberon def: "An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle." [UBERON:cjm] +subset: human_reference_atlas synonym: "cervical nerve plexus" EXACT [FMA:5904] synonym: "cervical plexus" EXACT [FMA:5904] synonym: "plexus cervicalis" EXACT LATIN [FMA:5904, FMA:TA] @@ -253764,8 +361486,13 @@ xref: MESH:D002572 xref: OpenCyc:Mx4rvkEE3JwpEbGdrcN5Y29ycA xref: SCTID:181107005 xref: Wikipedia:Cervical_plexus +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001813 ! spinal nerve plexus +intersection_of: UBERON:0001813 ! spinal nerve plexus +intersection_of: innervates UBERON:0007811 ! craniocervical region +relationship: innervates UBERON:0007811 ! craniocervical region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Gray784.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003726 @@ -253778,8 +361505,8 @@ synonym: "pectoral nerve" RELATED [GAID:857] synonym: "thoracic spinal nerve" EXACT [FMA:5860] xref: FMA:5860 xref: GAID:857 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1725 xref: MESH:D013900 +xref: neuronames:1725 xref: OpenCyc:Mx4rwSJp_ZwpEbGdrcN5Y29ycA xref: SCTID:360498003 xref: Wikipedia:Thoracic_nerves @@ -253824,7 +361551,7 @@ xref: EMAPA:36001 xref: FMA:9826 xref: GAID:94 xref: MA:0003075 -xref: MESH:A01.911.800.500 +xref: MESH:D008482 xref: NCIT:C12748 xref: OpenCyc:Mx4rv2OKJ5wpEbGdrcN5Y29ycA xref: SCTID:181217005 @@ -253833,6 +361560,7 @@ xref: Wikipedia:Mediastinum is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002553 ! anatomical cavity relationship: part_of UBERON:0002224 ! thoracic cavity +relationship: surrounded_by UBERON:0035431 ! mediastinal pleura property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ab/Mediastinum.png xsd:anyURI property_value: UBPROP:0000007 "mediastinal" xsd:string @@ -253867,7 +361595,6 @@ xref: NCIT:C77637 xref: Oral:mucosa xref: UMLS:C0026639 {source="ncithesaurus:Oral_Mucosa"} xref: Wikipedia:Oral_mucosa -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa @@ -253893,7 +361620,10 @@ synonym: "prostatic bud" EXACT [] xref: EMAPA:36141 is_a: UBERON:0004902 ! urogenital sinus epithelium is_a: UBERON:0005153 ! epithelial bud +intersection_of: UBERON:0005153 ! epithelial bud +intersection_of: has_potential_to_develop_into UBERON:0002367 ! prostate gland relationship: develops_from UBERON:0009847 {source="PMID:18977204"} ! prostate field +relationship: has_potential_to_develop_into UBERON:0002367 ! prostate gland property_value: UBPROP:0000009 "AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]" xsd:string [Term] @@ -253911,6 +361641,8 @@ xref: EMAPA:37284 {source="MA:th"} xref: MA:0000301 is_a: UBERON:0003606 ! limb long bone is_a: UBERON:0012357 ! digitopodium bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0009877 ! metapodium region relationship: part_of UBERON:0010546 {notes="https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern"} ! metapodial skeleton [Term] @@ -253949,6 +361681,10 @@ xref: VHOG:0000343 xref: VSAO:0005057 is_a: UBERON:0002472 ! stylopod is_a: UBERON:0008785 ! upper limb segment +intersection_of: UBERON:0002472 ! stylopod +intersection_of: part_of UBERON:0002102 ! forelimb +relationship: contributes_to_morphology_of UBERON:0002102 ! forelimb +relationship: has_skeleton UBERON:0015053 ! humerus endochondral element relationship: part_of UBERON:0001460 {source="MA"} ! arm property_value: UBPROP:0000001 "Segment of the hindleg corresponding to the humerus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000887", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000343", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} @@ -254011,6 +361747,10 @@ xref: VSAO:0005060 xref: Wikipedia:Forearm is_a: UBERON:0002471 ! zeugopod is_a: UBERON:0008784 ! lower limb segment +intersection_of: UBERON:0002471 ! zeugopod +intersection_of: part_of UBERON:0002103 ! hindlimb +relationship: contributes_to_morphology_of UBERON:0002103 ! hindlimb +relationship: has_skeleton UBERON:0010720 ! hindlimb zeugopod skeleton relationship: part_of UBERON:0000978 {source="MA"} ! leg property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000348", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"} property_value: UBPROP:0000007 "sural" xsd:string @@ -254058,6 +361798,8 @@ synonym: "femur" RELATED [https://sourceforge.net/tracker/index.php?func=detail& xref: EMAPA:35893 xref: MA:0000682 is_a: UBERON:0005893 ! leg bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0000376 ! hindlimb stylopod [Term] @@ -254345,6 +362087,8 @@ synonym: "paw joint" RELATED [MA:0002715] xref: EMAPA:35160 xref: MA:0002715 is_a: UBERON:0003657 ! limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: part_of UBERON:0002470 ! autopod region relationship: part_of UBERON:0002470 ! autopod region [Term] @@ -254400,17 +362144,36 @@ xref: XAO:0003203 xref: ZFA:0005134 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0005176 ! tooth enamel organ relationship: develops_from UBERON:0004362 {notes="epithelium", source="JB"} ! pharyngeal arch 1 relationship: part_of UBERON:0005176 ! tooth enamel organ property_value: editor_note "see comments for dental organ." xsd:string property_value: editor_note "todo - full developmental relationships" xsd:string property_value: UBPROP:0000011 "In the developing molar dentition of the mouse, tooth inductive po- tential resides in the dental epithelium until embryonic day (E)12.5 (3). Thereafter, tooth inductive potential shifts to neural crest-derived dental mesenchyme, which acquires the ability to direct tooth formation in nonodontogenic tissues (3, 4)" xsd:string {source="PMID:10954731"} +[Term] +id: UBERON:0003844 +name: upper eyelid epithelium +is_a: UBERON:0035034 ! eyelid epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001712 ! upper eyelid +relationship: part_of UBERON:0001712 ! upper eyelid + +[Term] +id: UBERON:0003845 +name: lower eyelid epithelium +is_a: UBERON:0035034 ! eyelid epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001713 ! lower eyelid +relationship: part_of UBERON:0001713 ! lower eyelid + [Term] id: UBERON:0003846 name: thymus epithelium namespace: uberon def: "An epithelium that is part of a thymus, forming a supporting framework[MP,modified]." [MP:0009544] +subset: human_reference_atlas subset: pheno_slim synonym: "epithelial tissue of thymus" EXACT [OBOL:automatic] synonym: "epithelial tissue of thymus gland" EXACT [OBOL:automatic] @@ -254433,7 +362196,20 @@ xref: ZFA:0005779 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002370 ! thymus +relationship: contributes_to_morphology_of UBERON:0002370 ! thymus +relationship: has_part CL:0002293 ! epithelial cell of thymus relationship: part_of UBERON:0002370 ! thymus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003847 +name: thyroid artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002046 ! thyroid gland +relationship: supplies UBERON:0002046 ! thyroid gland [Term] id: UBERON:0003848 @@ -254453,6 +362229,7 @@ xref: OpenCyc:Mx4rvlWYh5wpEbGdrcN5Y29ycA xref: SCTID:278192008 xref: VHOG:0001340 xref: Wikipedia:Gonadal_vein +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: attaches_to UBERON:0000991 ! gonad @@ -254623,12 +362400,33 @@ xref: VHOG_RETIRED:0001444 xref: ZFA:0005139 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007529 ! loose mesenchyme tissue +intersection_of: UBERON:0007529 ! loose mesenchyme tissue +intersection_of: part_of UBERON:0008281 ! tooth bud +relationship: adjacent_to UBERON:0005176 ! tooth enamel organ relationship: develops_from UBERON:0007213 {notes="see comments"} ! mesenchyme derived from head neural crest relationship: part_of UBERON:0008281 ! tooth bud property_value: editor_note "we follow ZFA in introducing an additional distinction between the dental papilla and the (uncondensed) mesenchyme. Note that in some species such as zebrafish teeth are not part of the mouth, and sharks have dermal denticles which share similar developmental origins with teeth. For now we assume a NC origin for all and add a taxon restriction to 1st arch mesenchyme" xsd:string property_value: UBPROP:0000001 "Mesenchyme enclosed by dental organ.[MP]" xsd:string {ontology="MP", source="J:153554"} property_value: UBPROP:0000001 "Mesenchyme enclosed by dental organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005139", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0003857 +name: upper eyelid mesenchyme +is_a: UBERON:0010330 ! eyelid mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001712 ! upper eyelid +relationship: develops_from UBERON:0000076 ! external ectoderm +relationship: part_of UBERON:0001712 ! upper eyelid + +[Term] +id: UBERON:0003858 +name: lower eyelid mesenchyme +is_a: UBERON:0010330 ! eyelid mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001713 ! lower eyelid +relationship: develops_from UBERON:0000076 ! external ectoderm +relationship: part_of UBERON:0001713 ! lower eyelid + [Term] id: UBERON:0003859 name: forelimb mesenchyme @@ -254764,6 +362562,8 @@ xref: SCTID:361806005 xref: UMLS:C1708088 {source="ncithesaurus:Foot_Digit_5_Phalanx"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0015035 ! pedal digit 5 phalanx endochondral element +intersection_of: UBERON:0003221 ! phalanx +intersection_of: part_of UBERON:0003635 ! pedal digit 5 relationship: develops_from UBERON:0010684 ! pedal digit 5 phalanx cartilage element [Term] @@ -254787,6 +362587,10 @@ xref: SCTID:371230003 xref: UMLS:C0223828 {source="ncithesaurus:Middle_Phalanx_of_the_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004301 ! middle phalanx +intersection_of: UBERON:0004301 ! middle phalanx +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: distally_connected_to UBERON:0001436 ! phalanx of manus +relationship: proximally_connected_to UBERON:0001436 ! phalanx of manus [Term] id: UBERON:0003865 @@ -254812,7 +362616,10 @@ xref: SCTID:361782004 xref: UMLS:C1269782 {source="ncithesaurus:Distal_Phalanx_of_Hand"} is_a: UBERON:0001436 ! phalanx of manus is_a: UBERON:0004300 ! distal phalanx +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0009552 ! distal segment of manual digit +relationship: proximally_connected_to UBERON:0001436 ! phalanx of manus [Term] id: UBERON:0003866 @@ -254831,6 +362638,10 @@ xref: MA:0001386 xref: SCTID:83207005 is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004301 ! middle phalanx +intersection_of: UBERON:0004301 ! middle phalanx +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: distally_connected_to UBERON:0001449 ! phalanx of pes +relationship: proximally_connected_to UBERON:0001449 ! phalanx of pes [Term] id: UBERON:0003867 @@ -254856,7 +362667,10 @@ xref: SCTID:361797001 xref: UMLS:C0224026 {source="ncithesaurus:Distal_Phalanx_of_Foot"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004300 ! distal phalanx +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0009553 ! distal segment of pedal digit +relationship: proximally_connected_to UBERON:0001449 ! phalanx of pes [Term] id: UBERON:0003868 @@ -254880,6 +362694,9 @@ xref: SCTID:85533000 xref: UMLS:C0224020 {source="ncithesaurus:Proximal_Phalanx_of_Foot"} is_a: UBERON:0001449 ! phalanx of pes is_a: UBERON:0004302 ! proximal phalanx +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: proximally_connected_to UBERON:0001448 ! metatarsal bone [Term] id: UBERON:0003869 @@ -254948,10 +362765,11 @@ xref: EFO:0002454 xref: EMAPA:32768 xref: FMA:74042 xref: HBA:12892 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=183 {source="BIRNLEX:1197"} xref: MA:0000950 xref: MBA:382 +xref: MESH:D056547 xref: NCIT:C32246 +xref: neuronames:183 {source="BIRNLEX:1197"} xref: PBA:10058 xref: UMLS:C0694598 {source="BIRNLEX:1197"} xref: UMLS:C0694598 {source="ncithesaurus:CA1_Field_of_the_Cornu_Ammonis"} @@ -254993,10 +362811,11 @@ xref: EFO:0002455 xref: EMAPA:32769 xref: FMA:74044 xref: HBA:12893 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=184 {source="BIRNLEX:1362"} xref: MA:0000951 xref: MBA:423 +xref: MESH:D056651 xref: NCIT:C32247 +xref: neuronames:184 {source="BIRNLEX:1362"} xref: PBA:10063 xref: UMLS:C0694599 {source="BIRNLEX:1362"} xref: UMLS:C0694599 {source="ncithesaurus:CA2_Field_of_the_Cornu_Ammonis"} @@ -255042,10 +362861,11 @@ xref: EFO:0002456 xref: EMAPA:32770 xref: FMA:74045 xref: HBA:12894 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=185 {source="BIRNLEX:1204"} xref: MA:0000952 xref: MBA:463 +xref: MESH:D056654 xref: NCIT:C32248 +xref: neuronames:185 {source="BIRNLEX:1204"} xref: PBA:10068 xref: UMLS:C0694600 {source="ncithesaurus:CA3_Field_of_the_Cornu_Ammonis"} xref: UMLS:C0694600 {source="BIRNLEX:1204"} @@ -255077,9 +362897,9 @@ xref: EFO:0002457 xref: EMAPA:32771 xref: FMA:75741 xref: HBA:12895 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=181 xref: MA:0000953 xref: NCIT:C32249 +xref: neuronames:181 xref: PBA:10074 xref: UMLS:C2328406 {source="ncithesaurus:CA4_Field_of_the_Cornu_Ammonis"} xref: Wikipedia:Region_IV_of_hippocampus_proper @@ -255091,6 +362911,7 @@ id: UBERON:0003885 name: mesometrium namespace: uberon def: "A mesentery that is part of a uterus [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "mesentery of uterus" RELATED [FMA:19816, http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/peritoneum.html, MA:0002931] xref: EMAPA:35562 xref: FMA:19816 @@ -255099,7 +362920,10 @@ xref: SCTID:250172001 xref: Wikipedia:Mesometrium is_a: UBERON:0001297 ! serosa of uterus is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0012332 ! broad ligament of uterus +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003886 @@ -255109,6 +362933,7 @@ def: "An anatomical cavity that has the potential to develop into a coelemic cav subset: grouping_class subset: non_informative synonym: "body cavity precursor" RELATED [] +synonym: "future coelomic cavity lumen" EXACT [] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space @@ -255178,6 +363003,7 @@ name: fallopian tube namespace: uberon def: "Initial section of the oviduct through which the ova pass from the ovary to the uterus." [http://orcid.org/0000-0002-6601-2165, MGI:smb, MP:0003574] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim synonym: "fallopian tubes" RELATED [] @@ -255206,9 +363032,17 @@ xref: Wikipedia:Fallopian_tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013515 ! subdivision of oviduct is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0013515 ! subdivision of oviduct +intersection_of: develops_from UBERON:0003890 ! Mullerian duct +intersection_of: part_of UBERON:0000993 ! oviduct +relationship: connects UBERON:0000995 ! uterus +relationship: connects UBERON:0003984 ! uterine tube infundibulum relationship: develops_from UBERON:0003890 ! Mullerian duct +relationship: in_lateral_side_of UBERON:0003975 {source="FMA-abduced-lr"} ! internal female genitalia +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0002355 ! pelvic region of trunk property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "Homologous to appendix testis" xsd:string {source="Wikipedia:Talk:Fallopian_tube#Homology"} [Term] @@ -255227,7 +363061,7 @@ xref: AAO:0010141 xref: EHDAA2:0004048 xref: EMAPA:27665 xref: GAID:1309 -xref: MESH:A16.254.570 +xref: MESH:D009095 xref: NCIT:C13260 xref: RETIRED_EHDAA2:0001399 xref: SCTID:308802006 @@ -255239,6 +363073,7 @@ is_a: UBERON:0000025 ! tube is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0015212 ! lateral structure relationship: develops_from UBERON:0003064 {source="Wikipedia"} ! intermediate mesoderm +relationship: in_lateral_side_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png xsd:anyURI property_value: UBPROP:0000001 "Either of the paired embryonic ducts developing into the uterine tubes, uterus, and vagina in the female and becoming largely obliterated in the male. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001199", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/paramesonephric+duct"} @@ -255256,7 +363091,6 @@ synonym: "stromal connective tissue" RELATED [] xref: FMA:81494 xref: NCIT:C67387 xref: UMLS:C0927195 {source="ncithesaurus:Stroma_Connective_Tissue"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0000064 ! organ part relationship: composed_primarily_of UBERON:0002384 ! connective tissue relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa @@ -255309,7 +363143,10 @@ is_a: UBERON:0001048 {source="XAO"} ! primordium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0002107 ! liver relationship: develops_from UBERON:0001041 {notes="ventral foregut endoderm", source="Zaret 1996"} ! foregut +relationship: has_potential_to_develop_into UBERON:0002107 ! liver relationship: part_of UBERON:0009550 {source="EHDAA2"} ! endoderm of foregut-midgut junction property_value: editor_note "consider adding further subdivisions of the endoderm, e.g. ventral foregut. Note we place two EFO classes here, it's not clear how they differ" xsd:string @@ -255336,6 +363173,7 @@ xref: EMAPA:18167 xref: MA:0003153 xref: RETIRED_EHDAA2:0000160 xref: TAO:0001954 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0014892 ! skeletal muscle organ intersection_of: UBERON:0014892 ! skeletal muscle organ intersection_of: attaches_to_part_of UBERON:0005944 ! axial skeleton plus cranial skeleton @@ -255402,6 +363240,7 @@ xref: UMLS:C1518263 {source="ncithesaurus:Neural_Retina"} xref: VHOG:0000535 xref: XAO:0003216 xref: ZFA:0000046 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001781 ! layer of retina intersection_of: UBERON:0001781 ! layer of retina intersection_of: immediate_transformation_of UBERON:0005425 ! presumptive neural retina @@ -255484,6 +363323,24 @@ property_value: UBPROP:0000001 "Fenestrated blood vessel endothelium with pores property_value: UBPROP:0000007 "sinusoidal" xsd:string property_value: UBPROP:0000012 "some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined)." xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0003910 +name: splenic sinusoid +is_a: UBERON:0003497 ! abdomen blood vessel +is_a: UBERON:0003909 ! sinusoid +intersection_of: UBERON:0003909 ! sinusoid +intersection_of: part_of UBERON:0001250 ! red pulp of spleen +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia +relationship: part_of UBERON:0001250 ! red pulp of spleen + +[Term] +id: UBERON:0003911 +name: choroid plexus epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001886 ! choroid plexus +relationship: part_of UBERON:0001886 ! choroid plexus + [Term] id: UBERON:0003913 name: tooth-like structure @@ -255494,6 +363351,8 @@ subset: grouping_class synonym: "tooth-like organ" EXACT [http://orcid.org/0000-0002-6601-2165] xref: HAO:0001019 is_a: UBERON:0004765 ! skeletal element +relationship: capable_of_part_of GO:0071626 ! mastication +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0003914 @@ -255533,6 +363392,7 @@ xref: EMAPA:35340 xref: FMA:58616 xref: MA:0002481 is_a: UBERON:0001013 ! adipose tissue +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: UBPROP:0000001 "An accumulation of adipose tissue (fat cells) enclosed in fibrous tissue[BTO]." xsd:string {ontology="BTO"} property_value: UBPROP:0000012 "FMA says isa fascia organ. Note that XAO and AAO have structures called fat pad/body, but these are gonad-associated, so we place them with the gonad-specific subclass" xsd:string {external_ontology="FMA"} @@ -255541,6 +363401,7 @@ id: UBERON:0003918 name: kidney mesenchyme namespace: uberon def: "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." [GO:0072074] +subset: human_reference_atlas subset: pheno_slim synonym: "mesenchyme of kidney" EXACT [] is_a: CARO:0000000 ! anatomical entity @@ -255549,6 +363410,7 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: has_potential_to_develop_into UBERON:0002113 ! kidney relationship: has_potential_to_develop_into UBERON:0002113 ! kidney property_value: editor_note "check this" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003920 @@ -255589,7 +363451,10 @@ xref: XAO:0001101 xref: ZFA:0000254 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001264 ! pancreas relationship: develops_from UBERON:0000925 {source="Wikipedia"} ! endoderm +relationship: has_potential_to_develop_into UBERON:0001264 ! pancreas relationship: part_of UBERON:0007026 ! presumptive gut property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI property_value: UBPROP:0000012 "in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds" xsd:string {external_ontology="EHDAA2"} @@ -255649,6 +363514,8 @@ xref: Wikipedia:Pancreatic_bud xref: XAO:0000467 xref: ZFA:0001370 is_a: UBERON:0003922 ! pancreatic epithelial bud +relationship: developmentally_induced_by UBERON:0002328 {gci_relation="part_of", gci_filler="NCBITaxon:10088", source="PMID:16417468"} ! notochord +relationship: developmentally_induced_by UBERON:0005805 {gci_relation="part_of", gci_filler="NCBITaxon:10088", source="PMID:16417468"} ! dorsal aorta relationship: develops_from UBERON:0001045 {source="XAO"} ! midgut relationship: part_of UBERON:0010375 {source="EHDAA2"} ! pancreas dorsal primordium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png xsd:anyURI @@ -255712,6 +363579,7 @@ synonym: "epithelial tissue of digestive tract" EXACT [OBOL:automatic] synonym: "epithelial tissue of gut" EXACT [OBOL:automatic] synonym: "epithelium of digestive tract" EXACT [OBOL:automatic] synonym: "epithelium of gut" EXACT [OBOL:automatic] +synonym: "gastrodermis" EXACT SENSU [https://orcid.org/0000-0003-3308-6245, NCBITaxon:6073] synonym: "gastrodermis" EXACT SENSU [BGEE:ANN, NCBITaxon:6073] synonym: "gut epithelial tissue" EXACT [OBOL:automatic] synonym: "gut epithelium" EXACT [EHDAA2:0004567, MA:0003201, ZFA:0005123] @@ -255831,7 +363699,7 @@ synonym: "transverse temporal gyri" RELATED PLURAL [Wikipedia:Transverse_tempora synonym: "transverse temporal gyrus" EXACT [Wikipedia:Transverse_temporal_gyrus] xref: BIRNLEX:1389 xref: FMA:273671 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1520 +xref: neuronames:1520 xref: SCTID:314159008 xref: Wikipedia:Transverse_temporal_gyrus is_a: UBERON:0000200 ! gyrus @@ -255855,8 +363723,8 @@ synonym: "vermis of the anterior lobe of the cerebellum" EXACT [BIRNLEX:1185] xref: BIRNLEX:1185 xref: FMA:72255 xref: HBA:4699 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=656 xref: MA:0002969 +xref: neuronames:656 is_a: UBERON:0004720 ! cerebellar vermis relationship: part_of UBERON:0002131 ! anterior lobe of cerebellum @@ -255871,7 +363739,7 @@ synonym: "somatic sensory system" EXACT [] synonym: "somatosensory system" EXACT [NLXANAT:090818] synonym: "system for detection of somatic senses" EXACT [] xref: EMAPA:37954 {source="MA:th"} -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2887 +xref: neuronames:2887 xref: NLXANAT:090818 xref: Wikipedia:Somatosensory_system is_a: UBERON:0001032 ! sensory system @@ -255922,6 +363790,7 @@ synonym: "labyrinthine layer of placenta" EXACT [GO:0060713] synonym: "placental labyrinth" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +relationship: contributes_to_morphology_of UBERON:0001987 ! placenta relationship: part_of UBERON:0001987 ! placenta property_value: RO:0002161 NCBITaxon:9606 {source="http://placentation.ucsd.edu"} property_value: seeAlso http://placentation.ucsd.edu/placenta.html xsd:anyURI @@ -255935,6 +363804,9 @@ def: "The brain ventricles or their associated choroid plexuses." [MP:0002200] subset: pheno_slim is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010000 ! multicellular anatomical structure +union_of: UBERON:0001886 ! choroid plexus +union_of: UBERON:0004086 ! brain ventricle +relationship: contributes_to_morphology_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain property_value: editor_note "TODO - check relationship between CP and BV. If this is part of then this class should be obsoleted" xsd:string property_value: editor_note "TODO merge into BV" xsd:string @@ -256006,6 +363878,7 @@ id: UBERON:0003952 name: anterior stroma of cornea namespace: uberon def: "The anterior segment of the lamellated connective tissue layer of the cornea." [MP:0003093] +subset: human_reference_atlas subset: pheno_slim synonym: "anterior stroma" BROAD [MP:0003093] synonym: "cornea anterior stroma" EXACT [MP:0003093] @@ -256018,6 +363891,7 @@ disjoint_from: UBERON:0003953 {source="lexical"} ! posterior stroma of cornea relationship: contributes_to_morphology_of UBERON:0001777 ! substantia propria of cornea relationship: in_anterior_side_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003953 @@ -256054,7 +363928,7 @@ xref: SCTID:136248004 xref: SCTID:334174000 xref: Wikipedia:Squamosal_suture is_a: UBERON:0003685 ! cranial suture -property_value: depicted:by Gray188-Squamosal:suture.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a8/Gray188-Squamosal_suture.png xsd:anyURI [Term] id: UBERON:0003955 @@ -256105,6 +363979,9 @@ xref: Wikipedia:Bruch's_membrane xref: ZFA:0005562 is_a: UBERON:0000476 {source="ZFA"} ! acellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure +relationship: adjacent_to UBERON:0001782 ! pigmented layer of retina +relationship: has_part GO:0005604 ! basement membrane +relationship: has_part GO:0071953 ! elastic fiber relationship: part_of UBERON:0013399 ! blood vessel layer of choroid property_value: seeAlso https://github.com/obophenotype/uberon/issues/14 xsd:anyURI property_value: UBPROP:0000010 "Bruch's membrane consists of five layers (from inside to outside): 1. the basement membrane of the retinal pigment epithelium; 2. the inner collagenous zone; 3. a central band of elastic fibers; 4. the outer collagenous zone; 5. the basement membrane of the choriocapillaris. The retinal pigment epithelium transports metabolic waste from the photoreceptors across Bruch's membrane to the choroid[WP]" xsd:string @@ -256139,6 +364016,9 @@ xref: Wikipedia:Rete_testis is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +relationship: channel_for CL:0000019 ! sperm +relationship: channels_from UBERON:0001343 ! seminiferous tubule of testis +relationship: channels_into UBERON:0006946 ! efferent duct relationship: develops_from UBERON:0005297 {source="Wikipedia"} ! testis sex cord relationship: part_of UBERON:0005051 ! mediastinum testis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg xsd:anyURI @@ -256185,8 +364065,8 @@ xref: EMAPA:37828 {source="MA:th"} xref: FMA:260761 xref: FMA:83869 xref: HBA:9240 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1445 xref: MBA:940 +xref: neuronames:1445 xref: SCTID:369084007 is_a: UBERON:0007702 ! tract of brain relationship: part_of UBERON:0003544 ! brain white matter @@ -256231,8 +364111,13 @@ xref: EMAPA:36274 xref: FMA:6967 xref: SCTID:279283005 xref: Wikipedia:Otic_ganglion +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001701 ! glossopharyngeal ganglion is_a: UBERON:0001808 ! parasympathetic ganglion +intersection_of: UBERON:0001714 ! cranial ganglion +intersection_of: extends_fibers_into UBERON:0001649 ! glossopharyngeal nerve +intersection_of: innervates UBERON:0001831 ! parotid gland +relationship: innervates UBERON:0001831 ! parotid gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/64/Gray783.png xsd:anyURI [Term] @@ -256315,6 +364200,8 @@ synonym: "placental vasculature" RELATED [OBOL:automatic] synonym: "vasculature of placenta labyrinth" EXACT [] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0003946 ! placenta labyrinth relationship: part_of UBERON:0003946 ! placenta labyrinth [Term] @@ -256439,6 +364326,7 @@ xref: FMA:67611 xref: galen:Valve xref: OpenCyc:Mx4rvqiwE5wpEbGdrcN5Y29ycA is_a: UBERON:0000064 ! organ part +relationship: capable_of GO:0065008 ! regulation of biological quality property_value: UBPROP:0000007 "valvular" xsd:string [Term] @@ -256471,9 +364359,11 @@ xref: DHBA:12828 xref: EMAPA:37818 {source="MA:th"} xref: FMA:321547 xref: HBA:9406 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1213 +xref: neuronames:1213 xref: SCTID:314163001 is_a: UBERON:0014466 ! subarachnoid fissure +intersection_of: UBERON:0014466 ! subarachnoid fissure +intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum property_value: UBPROP:0000202 FMA:77789 @@ -256482,6 +364372,7 @@ id: UBERON:0003981 name: primordial ovarian follicle namespace: uberon def: "Primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles." [MP:0009361] +subset: human_reference_atlas subset: pheno_slim synonym: "ovary primordial follicle" EXACT [MA:0001710] synonym: "primordial follicle" EXACT [] @@ -256490,6 +364381,7 @@ xref: MA:0001710 xref: NCIT:C33400 xref: UMLS:C1514441 {source="ncithesaurus:Primordial_Follicle"} is_a: UBERON:0001305 ! ovarian follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003982 @@ -256497,6 +364389,7 @@ name: mature ovarian follicle namespace: uberon def: "." [MP:0009364] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "antral follicle" RELATED [BTO:0000389] @@ -256512,13 +364405,29 @@ xref: TAO:0001264 xref: ZFA:0001264 is_a: UBERON:0001305 ! ovarian follicle relationship: develops_from UBERON:0003981 ! primordial ovarian follicle +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Stage IV (690-730 microns) are oocyte maturation. Selman et al, 1993.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001264", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0003983 +name: conus arteriosus +namespace: uberon +def: "A conical pouch formed from the upper and left angle of the right ventricle in the chordate heart, from which the pulmonary artery arises[WP]. the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminates in the pulmonary trunk[MP]." [MP:0009464, Wikipedia:Conus_arteriosus] +xref: AAO:0010250 +xref: Wikipedia:Conus_arteriosus +is_a: UBERON:0004151 ! cardiac chamber +relationship: part_of UBERON:0002080 ! heart right ventricle +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png xsd:anyURI +property_value: UBPROP:0000001 "Receives blood from the left atrium and becomes the median truncus arteriosus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010250", ontology="AAO", source="AAO:BJB"} +property_value: UBPROP:0000008 "Kardong says absent in adult tetrapods, check AAO" xsd:string +property_value: UBPROP:0000013 "we use the term CA for the anterior chamber if it is composed of cardiac muscle, contractile, and contains conal valves internally" xsd:string {source="ISBN:0073040584"} + [Term] id: UBERON:0003984 name: uterine tube infundibulum namespace: uberon def: "The funnel-like expansion of the abdominal extremity of the uterine tube[MP]." [MP:0009466, Wikipedia:Infundibulum_of_uterine_tube] +subset: human_reference_atlas subset: pheno_slim synonym: "infundibulum" BROAD INCONSISTENT [] synonym: "infundibulum of fallopian tube" NARROW [FMA:18307] @@ -256530,8 +364439,11 @@ xref: FMA:18307 xref: SCTID:362262001 xref: Wikipedia:Infundibulum_of_uterine_tube is_a: UBERON:0013515 {source="FMA"} ! subdivision of oviduct -property_value: depicted:by Illu:cervix.jpg xsd:anyURI +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: part_of UBERON:0003889 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! fallopian tube +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg xsd:anyURI property_value: RO:0002175 NCBITaxon:8782 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]." xsd:string {source="Wikipedia:Infundibulum_of_uterine_tube"} property_value: UBPROP:0000008 "In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct." xsd:string {xref="https://orcid.org/0000-0002-2825-0621"} @@ -256566,6 +364478,7 @@ id: UBERON:0003987 name: Hassall's corpuscle namespace: uberon def: "The small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages." [MP:0009539] +subset: human_reference_atlas subset: pheno_slim synonym: "capsule of Hassal's corpuscle" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "thymic corpuscle" EXACT [] @@ -256579,12 +364492,14 @@ is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0034922 ! cell cluster relationship: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0003846 ! thymus epithelium +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003988 name: thymus corticomedullary boundary namespace: uberon def: "The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells." [MP:0009543] +subset: human_reference_atlas subset: pheno_slim synonym: "thymic cortico-medullary boundary" EXACT [MP:0009543] synonym: "thymic corticomedullary boundary" EXACT [MP:0009543] @@ -256597,7 +364512,18 @@ synonym: "thymus corticomedullary zone" EXACT [MP:0009543] xref: EMAPA:37974 {source="MA:th"} is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0007651 ! anatomical junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: overlaps UBERON:0002123 ! cortex of thymus +intersection_of: overlaps UBERON:0002124 ! medulla of thymus +relationship: contributes_to_morphology_of UBERON:0002125 ! thymus lobule +relationship: has_part CL:0000451 ! dendritic cell +relationship: has_part CL:0000542 ! lymphocyte +relationship: has_part CL:0000881 ! perivascular macrophage +relationship: has_part UBERON:0001980 ! arteriole +relationship: overlaps UBERON:0002123 ! cortex of thymus +relationship: overlaps UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002125 ! thymus lobule +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003989 @@ -256613,7 +364539,7 @@ synonym: "ventral median fissure of medulla" EXACT [FMA:83734] synonym: "ventral median sulcus" EXACT [FMA:83734] xref: BAMS:amf xref: FMA:83734 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=700 +xref: neuronames:700 xref: SCTID:279288001 xref: Wikipedia:Anterior_median_fissure_of_the_medulla_oblongata is_a: UBERON:0013118 ! sulcus of brain @@ -256644,9 +364570,9 @@ synonym: "median aperture of fourth ventricle" EXACT [FMA:75015] xref: BAMS:MA4V xref: BAMS:MAP xref: FMA:75015 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=641 xref: MA:0002947 xref: NCIT:C32626 +xref: neuronames:641 xref: SCTID:279449001 xref: UMLS:C0152288 {source="ncithesaurus:Foramen_of_Magendie"} xref: Wikipedia:Median_aperture @@ -256671,14 +364597,14 @@ synonym: "lateral aperture of fourth ventricle" EXACT [FMA:78473] xref: BAMS:LA4V xref: BAMS:LAP xref: FMA:78473 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=640 xref: MA:0002946 xref: NCIT:C32625 +xref: neuronames:640 xref: SCTID:63426007 xref: UMLS:C0152287 {source="ncithesaurus:Foramen_of_Luschka"} xref: Wikipedia:Lateral_aperture is_a: UBERON:0004668 ! fourth ventricle aperture -property_value: depicted:by Lateral:ventricle.gif xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/54/Lateral_ventricle.gif xsd:anyURI [Term] id: UBERON:0003993 @@ -256695,9 +364621,9 @@ xref: BAMS:ivf xref: DHBA:10608 xref: EMAPA:36067 xref: FMA:75351 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=447 xref: MBA:124 xref: NCIT:C32627 +xref: neuronames:447 xref: SCTID:279248006 xref: UMLS:C0016520 {source="ncithesaurus:Foramen_of_Monroe"} xref: Wikipedia:Interventricular_foramina_(neural_anatomy) @@ -256748,7 +364674,6 @@ xref: FMA:23976 xref: MA:0002954 xref: SCTID:181891000 xref: Wikipedia:Anterior_arch_of_atlas -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004530 ! bony projection relationship: part_of UBERON:0001092 ! vertebral bone 1 property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9a/Arcusanterioratlantis.png xsd:anyURI @@ -256855,6 +364780,9 @@ synonym: "palpebral gland acinus" RELATED [] xref: EMAPA:37972 {source="MA:th"} is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011846 ! acinus of sebaceous gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0001818 ! tarsal gland +relationship: contributes_to_morphology_of UBERON:0001818 ! tarsal gland relationship: part_of UBERON:0001818 ! tarsal gland [Term] @@ -256868,6 +364796,9 @@ xref: EMAPA:37917 {source="MA:th"} xref: NLXANAT:20090402 is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer +intersection_of: UBERON:0022303 ! nervous system cell part layer +intersection_of: part_of UBERON:0002264 ! olfactory bulb +relationship: contributes_to_morphology_of UBERON:0002264 ! olfactory bulb relationship: part_of UBERON:0002264 ! olfactory bulb property_value: editor_note "TODO - check isa parentage" xsd:string @@ -256890,8 +364821,8 @@ xref: BIRNLEX:911 xref: DHBA:12844 xref: EMAPA:35222 xref: FMA:72252 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=660 xref: MA:0002964 +xref: neuronames:660 xref: SCTID:279360009 xref: Wikipedia:Posterior_lobe_of_cerebellum is_a: UBERON:0005293 ! cerebellum lobe @@ -256941,8 +364872,8 @@ synonym: "paravermis" EXACT [MP:0009966] synonym: "spinocerebellum" RELATED [Wikipedia:Cerebellar_hemisphere] xref: EMAPA:37822 {source="MA:th"} xref: HBA:9611 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2066 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2129 +xref: neuronames:2066 +xref: neuronames:2129 xref: NLXANAT:20081236 xref: PBA:294021942 is_a: UBERON:0002749 ! regional part of cerebellar cortex @@ -256959,7 +364890,7 @@ synonym: "cerebellum plate" EXACT [] synonym: "cerebellum roof plate" RELATED [EHDAA2:0004401] xref: DHBA:12698 xref: EHDAA2:0004401 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1373 +xref: neuronames:1373 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -256982,8 +364913,8 @@ synonym: "vermis of the posterior lobe of the cerebellum" EXACT [NLXANAT:2008124 xref: BAMS:VPLb xref: FMA:72259 xref: HBA:4704 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=673 xref: MA:0002970 +xref: neuronames:673 xref: NLXANAT:20081240 is_a: UBERON:0004720 ! cerebellar vermis relationship: part_of UBERON:0004002 ! posterior lobe of cerebellum @@ -257041,7 +364972,8 @@ synonym: "labia minorum" EXACT [] synonym: "labium minora" EXACT [] synonym: "labium minorum" EXACT [MA:0002845] synonym: "labium minus" EXACT [FMA:20374] -synonym: "labium minus pudendi" RELATED LATIN [Wikipedia:Labia_minora] +synonym: "labium minus pudendi" EXACT LATIN [Wikipedia:Labia_minora] +synonym: "labium minus pudendi" EXACT DEPRECATED [doi:10.1002/ca.23705] xref: FMA:20374 xref: galen:LabiaMinora xref: MA:0002845 @@ -257061,7 +364993,6 @@ namespace: uberon def: "The connection between the embryo proper and extraembryonic tissues" [MP:0003890] def: "The connection between the embryo proper and extraembryonic tissues." [MP:0003890] subset: pheno_slim -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000015 ! non-material anatomical boundary intersection_of: UBERON:0000015 ! non-material anatomical boundary intersection_of: adjacent_to UBERON:0000478 ! extraembryonic structure @@ -257251,6 +365182,7 @@ id: UBERON:0004027 name: chorionic plate namespace: uberon def: "That portion of the chorionic wall in the region of its uterine attachment, which gives rise to chorionic villi; it consists of the mesoderm that lines the chorionic vesicle and, on the maternal side, of the trophoblast that lines the intervillous spaces; in the last half of gestation, the mesodermal connective tissue is largely replaced by fibrinoid material, and the amnionic membrane is adherent to the fetal side of the plate." [http://www.medilexicon.com/medicaldictionary.php?t=69523, MP:0004560] +subset: human_reference_atlas subset: pheno_slim xref: BTO:0002879 xref: EMAPA:31872 @@ -257259,7 +365191,9 @@ xref: SCTID:256391000 xref: UMLS:C0230972 {source="ncithesaurus:Chorionic_Plate"} is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue +relationship: contributes_to_morphology_of UBERON:0003124 ! chorion membrane relationship: part_of UBERON:0003124 ! chorion membrane +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004029 @@ -257352,8 +365286,8 @@ synonym: "subplate" EXACT [] synonym: "subplate zone" EXACT [DHBA:10522] xref: DHBA:10522 xref: EMAPA:32703 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3233 xref: https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png/360px-Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png +xref: neuronames:3233 xref: PBA:294021932 xref: Wikipedia:Subplate is_a: UBERON:0014950 ! layer of developing cerebral cortex @@ -257386,12 +365320,14 @@ id: UBERON:0004041 name: spleen primary B follicle namespace: uberon def: "The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp." [MP:0008471] +subset: human_reference_atlas subset: pheno_slim synonym: "primary spleen B cell follicle" EXACT [CL:tm] xref: EMAPA:37960 {source="MA:th"} xref: FMA:15843 is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0010422 ! primary nodular lymphoid tissue +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "FMA:15843 is classified as primary follicle so it belongs here" xsd:string {external_ontology="FMA"} [Term] @@ -257399,6 +365335,7 @@ id: UBERON:0004042 name: spleen secondary B follicle namespace: uberon def: "The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp." [MP:0008472] +subset: human_reference_atlas subset: pheno_slim synonym: "secondary spleen B cell follicle" EXACT [CL:tm] synonym: "splenic secondary B cell follicle" EXACT [MP:0008472] @@ -257406,6 +365343,7 @@ xref: EMAPA:37961 {source="MA:th"} is_a: UBERON:0001249 ! spleen lymphoid follicle is_a: UBERON:0001745 ! secondary nodular lymphoid tissue relationship: develops_from UBERON:0004041 {source="CL:tm"} ! spleen primary B follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004043 @@ -257473,8 +365411,8 @@ xref: BAMS:icis xref: BAMS:IPCi xref: EMAPA:19056 xref: FMA:83718 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2353 xref: NCIT:C32866 +xref: neuronames:2353 xref: Wikipedia:Interpeduncular_cistern is_a: UBERON:0004050 ! subarachnoid cistern @@ -257489,7 +365427,7 @@ xref: BAMS:pcis xref: BAMS:PoCi xref: EMAPA:18212 xref: FMA:83719 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=556 +xref: neuronames:556 xref: Wikipedia:Pontine_cistern is_a: UBERON:0004050 ! subarachnoid cistern is_a: UBERON:0005219 ! hindbrain subarachnoid space @@ -257506,7 +365444,7 @@ xref: BAMS:cmcis xref: BAMS:GrCi xref: EMAPA:37814 {source="MA:th"} xref: FMA:74517 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=542 +xref: neuronames:542 is_a: UBERON:0004050 ! subarachnoid cistern [Term] @@ -257553,8 +365491,8 @@ synonym: "superior cistern" EXACT [FMA:74511] xref: BAMS:scis xref: EMAPA:37817 {source="MA:th"} xref: FMA:74511 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=26 xref: NCIT:C33444 +xref: neuronames:26 xref: SCTID:56154003 xref: UMLS:C0228150 {source="ncithesaurus:Quadrigeminal_Cistern"} xref: Wikipedia:Cistern_of_great_cerebral_vein @@ -257578,6 +365516,11 @@ xref: galen:MaleExternalGenitalia xref: SCTID:362264000 is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004176 ! external genitalia +intersection_of: UBERON:0004176 ! external genitalia +intersection_of: part_of UBERON:0000079 ! male reproductive system +disjoint_from: UBERON:0005056 ! external female genitalia +disjoint_from: UBERON:0009196 ! indifferent external genitalia +relationship: contributes_to_morphology_of UBERON:0000079 ! male reproductive system [Term] id: UBERON:0004054 @@ -257595,6 +365538,9 @@ xref: FMA:45655 xref: SCTID:310536002 is_a: UBERON:0003135 ! male reproductive organ is_a: UBERON:0004175 ! internal genitalia +intersection_of: UBERON:0004175 ! internal genitalia +intersection_of: part_of UBERON:0000079 ! male reproductive system +relationship: contributes_to_morphology_of UBERON:0000079 ! male reproductive system property_value: editor_note "consider splitting genitalia from genital organ" xsd:string [Term] @@ -257645,6 +365591,7 @@ id: UBERON:0004058 name: biliary ductule namespace: uberon def: "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." [BTO:0002840, MP:0009494] +subset: human_reference_atlas subset: pheno_slim synonym: "bile capillary" RELATED [BTO:0002840] synonym: "bile ductule" EXACT [BTO:0002840] @@ -257659,8 +365606,10 @@ xref: TAO:0005164 xref: ZFA:0005164 is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure +relationship: adjacent_to UBERON:0001175 ! common hepatic duct relationship: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002394 {source="BTO"} ! bile duct +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "In ZFA, Digestive system duct that collects bile from the canaliculus and transports bile through the liver -- (check if the same) // The smallest and the most peripheral branches of the biliary tree consist of a portal part (portal ductule) and an intralobular part (intralobular ductule)" xsd:string {external_ontology="ZFA"} [Term] @@ -257708,6 +365657,7 @@ synonym: "neural tube intermediate zone" EXACT [http://www.ncbi.nlm.nih.gov/book xref: EMAPA:17148 xref: EMAPA:35360 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1367 +xref: neuronames:1367 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034707 {source="NCBIBook:NBK10047"} ! differentiating neuroepithelium @@ -257727,6 +365677,7 @@ synonym: "brain marginal zone" RELATED [] synonym: "neural tube marginal zone" EXACT [MP:0009691] xref: EMAPA:17151 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1368 +xref: neuronames:1368 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005162 ! multi cell part structure relationship: adjacent_to UBERON:0004061 ! neural tube mantle layer @@ -257763,11 +365714,11 @@ synonym: "spinal cord basal plate" NARROW [MP:0009693] synonym: "ventral part of neural tube" RELATED [] xref: AAO:0010561 xref: EFO:0001904 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1372 xref: NCIT:C34111 +xref: neuronames:1372 xref: UMLS:C1511061 {source="ncithesaurus:Basal_Plate"} xref: Wikipedia:Basal_plate_(neural_tube) -is_a: BFO:0000040 ! material entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: contributes_to_morphology_of UBERON:0004061 ! neural tube mantle layer @@ -257798,6 +365749,7 @@ xref: UMLS:C1517321 {source="ncithesaurus:Frontonasal_Prominence"} xref: VHOG:0001319 xref: Wikipedia:Frontonasal_prominence is_a: UBERON:0009292 ! embryonic nasal process +relationship: BSPO:0005001 UBERON:0000033 ! head property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png xsd:anyURI [Term] @@ -257843,6 +365795,7 @@ xref: Wikipedia:Medial_nasal_prominence is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0009292 ! embryonic nasal process relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence +relationship: in_lateral_side_of UBERON:0008816 ! embryonic head relationship: part_of UBERON:0004066 {source="EHDAA2"} ! frontonasal prominence property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png xsd:anyURI property_value: UBPROP:0000011 "Fusion of right and left medial nasal processes forms a primary palate rostrally and the nasal septum caudally. The incisive bone, including upper incisor teeth and the rostral up- per lip, are derived from the primary palate. The nasal septum consists of bone, cartilage, and a patch of soft tissue membrane that separates right & left halves of the nasal cavity." xsd:string @@ -257862,9 +365815,9 @@ xref: BAMS:AOLB xref: BTO:0004797 xref: DMBA:15957 xref: EMAPA:35106 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1565 xref: MA:0000966 xref: MBA:151 +xref: neuronames:1565 xref: NLX:53 xref: NLXANAT:20090453 xref: Wikipedia:Olfactory_bulb#Accessory_olfactory_bulb @@ -257910,7 +365863,7 @@ xref: DHBA:12613 xref: DMBA:16929 xref: EMAPA:37819 {source="MA:th"} xref: HBA:9578 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1243 +xref: neuronames:1243 xref: NLXANAT:20081242 xref: Wikipedia:Interposed_nucleus is_a: UBERON:0008995 ! nucleus of cerebellar nuclear complex @@ -257940,9 +365893,9 @@ xref: BAMS:LING xref: BIRNLEX:932 xref: EMAPA:35225 xref: FMA:83884 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=657 xref: MA:0000998 xref: MBA:912 +xref: neuronames:657 xref: NLXANAT:20081224 xref: SCTID:279380005 xref: SCTID:77232000 @@ -257964,9 +365917,9 @@ synonym: "lobule II of cerebellum vermis" EXACT [] synonym: "vermic lobule II" EXACT [NLXANAT:20081225] xref: EMAPA:35226 xref: FMA:278635 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1054 xref: MA:0000999 xref: MBA:976 +xref: neuronames:1054 xref: NLXANAT:20081225 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: part_of UBERON:0003021 {source="ABA"} ! central lobule @@ -257987,9 +365940,9 @@ xref: DHBA:12841 xref: EMAPA:35227 xref: FMA:278639 xref: HBA:12933 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1844 xref: MA:0001000 xref: MBA:984 +xref: neuronames:1844 xref: NLXANAT:20081226 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: part_of UBERON:0003021 {source="ABA"} ! central lobule @@ -258039,9 +365992,9 @@ xref: DHBA:12851 xref: EMAPA:35229 xref: FMA:83883 xref: HBA:12943 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=678 xref: MA:0001006 xref: MBA:957 +xref: neuronames:678 xref: NLXANAT:20081234 xref: Wikipedia:Uvula_of_cerebellum is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule @@ -258065,9 +366018,9 @@ xref: BAMS:Cul xref: DHBA:12843 xref: EMAPA:35230 xref: HBA:12935 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1766 xref: MA:0001002 xref: MBA:1001 +xref: neuronames:1766 xref: NLXANAT:20081228 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: part_of UBERON:0007763 {source="ABA"} ! cerebellum vermis culmen @@ -258077,7 +366030,6 @@ id: UBERON:0004080 name: cerebellum vermis lobule VI namespace: uberon alt_id: UBERON:0000909 -alt_id: UBERON:Declive-MA_0001003 def: "." [MP:0009994] subset: pheno_slim synonym: "declive" BROAD [MA:0001003] @@ -258096,9 +366048,9 @@ xref: DHBA:12845 xref: EMAPA:35231 xref: FMA:83887 xref: HBA:12937 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=674 xref: MA:0001003 xref: MBA:936 +xref: neuronames:674 xref: NLXANAT:20081229 xref: SCTID:279385000 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule @@ -258116,9 +366068,9 @@ synonym: "vermic lobule VII" EXACT [NLXANAT:20081230] xref: BAMS:FOTU xref: EMAPA:35232 xref: FMA:278651 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2464 xref: MA:0001004 xref: MBA:944 +xref: neuronames:2464 xref: NLXANAT:20081230 xref: SCTID:369044003 xref: Wikipedia:Folium_(vermis) @@ -258150,9 +366102,9 @@ synonym: "vermic lobule VIII" EXACT [NLXANAT:20081233] xref: BAMS:PYR xref: EMAPA:35233 xref: FMA:83888 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=677 xref: MA:0001005 xref: MBA:951 +xref: neuronames:677 xref: NLXANAT:20081233 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: part_of UBERON:0004009 ! cerebellum posterior vermis @@ -258168,7 +366120,7 @@ synonym: "lobule X of vermis of cerebellum" RELATED [FMA:83882] synonym: "neuraxis nodule" EXACT [UBERON:cjm] synonym: "neuraxis nodulus" EXACT [] synonym: "nodule" BROAD [NeuroNames:681] -synonym: "nodulus" BROAD [http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=681, MA:0001007] +synonym: "nodulus" BROAD [MA:0001007, neuronames:681] synonym: "nodulus" RELATED [NLXANAT:20081235] synonym: "nodulus (X)" EXACT [ABA:NOD] synonym: "nodulus of cerebellum" EXACT [] @@ -258179,9 +366131,9 @@ xref: BIRNLEX:1165 xref: EMAPA:35234 xref: FMA:83882 xref: HBA:4713 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=681 xref: MA:0001007 xref: MBA:968 +xref: neuronames:681 xref: NLXANAT:20081235 is_a: UBERON:0004070 {source="MA"} ! cerebellum vermis lobule relationship: part_of UBERON:0003012 {source="NIFSTD"} ! flocculonodular lobe @@ -258205,6 +366157,9 @@ xref: UMLS:C0227759 {source="ncithesaurus:Labium"} is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0015212 ! lateral structure +relationship: contributes_to_morphology_of UBERON:0005056 ! external female genitalia +relationship: in_lateral_side_of UBERON:0005056 ! external female genitalia +relationship: only_in_taxon NCBITaxon:9347 ! Eutheria relationship: part_of UBERON:0000997 {source="MA"} ! mammalian vulva property_value: UBPROP:0000007 "labial" xsd:string @@ -258218,7 +366173,8 @@ synonym: "labia majorum" EXACT [] synonym: "labium majora" EXACT [] synonym: "labium majorum" EXACT [MA:0002844] synonym: "labium majus" EXACT [] -synonym: "labium majus pudendi" RELATED LATIN [Wikipedia:Labia_majora] +synonym: "labium majus pudendi" EXACT LATIN [Wikipedia:Labia_majora] +synonym: "labium majus pudendi" EXACT DEPRECATED [doi:10.1002/ca.23705] xref: FMA:20367 xref: galen:LabiaMajora xref: MA:0002844 @@ -258237,6 +366193,7 @@ name: brain ventricle namespace: uberon def: "One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid." [https://github.com/obophenotype/uberon/issues/300] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim synonym: "brain ventricles" EXACT PLURAL [] synonym: "cerebral ventricle" EXACT [HP:0002118] @@ -258247,16 +366204,17 @@ xref: EFO:0001914 xref: EMAPA:32674 xref: FMA:78447 xref: HBA:9418 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2497 xref: MA:0000818 xref: MESH:D002552 xref: NCIT:C12356 +xref: neuronames:2497 xref: OpenCyc:Mx4rvmTY65wpEbGdrcN5Y29ycA xref: SCTID:180929003 xref: UMLS:C0007799 {source="ncithesaurus:Ventricle_Brain"} is_a: UBERON:0003947 ! brain ventricle/choroid plexus is_a: UBERON:0005358 ! ventricle of nervous system relationship: part_of UBERON:0005282 ! ventricular system of brain +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Organ cavity of the brain which consists of the lateral ventricles, the third and fourth ventricles and the cerebral aqueduct[BIRNLEX:1356]." xsd:string {source="BIRNLEX:1356"} property_value: UBPROP:0000012 "FMA draws the distinction between e.g. 'fourth ventricle' and 'cavity of fourth ventricle'. The latter is a cavity, and part of the former, which is a region. The superclass of 'fourth ventricle' is_a 'region of ventricular system of the brain'. We place this class here, although it is not equivalent to ventricles, as it includes ventricle bodies." xsd:string {external_ontology="FMA"} @@ -258289,6 +366247,7 @@ is_a: UBERON:0003479 ! thoracic cavity vein is_a: UBERON:0013768 ! great vessel of heart property_value: depicted:by Heart:numlabels.png xsd:anyURI property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png xsd:anyURI [Term] id: UBERON:0004088 @@ -258323,6 +366282,8 @@ xref: EMAPA:32806 xref: FMA:285406 xref: MA:0001910 is_a: UBERON:0001444 ! subdivision of head +relationship: contributes_to_morphology_of UBERON:0001456 ! face +relationship: only_in_taxon NCBITaxon:89593 ! Craniata relationship: part_of UBERON:0001456 ! face property_value: editor_note "this class is currently a union of the snout (e.g. in mouse), the midface and the lower face. Note that in MA, snout includes the whole jaw and should thus be more alike the lower face than the midface, so its placement here is not strictly accurate. In future we might introduce specific classes for each of these, and include the full parthood relationships. if this is done, then care should be taken to preserve inferences such as an abnormality of the lower face being an abnormality of the midface." xsd:string property_value: UBPROP:0000007 "midfacial" xsd:string @@ -258379,7 +366340,6 @@ xref: OpenCyc:Mx4rwIYGoJwpEbGdrcN5Y29ycA xref: SCTID:181899003 xref: UMLS:C0028881 {source="ncithesaurus:Odontoid_Process"} xref: Wikipedia:Dens_(anatomy) -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004530 ! bony projection relationship: part_of UBERON:0001093 ! vertebral bone 2 property_value: editor_note "TODO check AAO:0000721 odontoid_process -- Anterior process located between the atlantal cotyles that projects into the foramen magnum of the skull and bears facets that articulate with the lateral walls of the foramen" xsd:string @@ -258390,10 +366350,12 @@ id: UBERON:0004098 name: tibial plateaux namespace: uberon def: "." [HP:0003832] +subset: human_reference_atlas subset: pheno_slim is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005055 ! zone of long bone relationship: part_of UBERON:0000979 ! tibia +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004099 @@ -258403,8 +366365,12 @@ def: "Joint cavity shared by all the joints of the elbow. The elbow joint is a c subset: pheno_slim synonym: "synovial cavity of elbow joint" EXACT [FMA:38911] xref: FMA:38911 +is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001490 ! elbow joint +relationship: luminal_space_of UBERON:0001490 ! elbow joint relationship: part_of UBERON:0001490 ! elbow joint [Term] @@ -258412,6 +366378,7 @@ id: UBERON:0004100 name: renal collecting system namespace: uberon def: "The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone." [HP:0004742, Wikipedia:Collecting_duct_system] +subset: human_reference_atlas subset: pheno_slim synonym: "collecting duct system" EXACT [Wikipedia:Collecting_duct_system] synonym: "kidney collecting duct system" EXACT [Wikipedia:Collecting_duct_system] @@ -258423,6 +366390,7 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000467 ! anatomical system relationship: part_of UBERON:0002113 ! kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004101 @@ -258457,6 +366425,7 @@ xref: UMLS:C0447411 {source="ncithesaurus:Alveolar_Ridge"} xref: Wikipedia:Alveolar_ridge is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010313 ! neural crest-derived structure +relationship: has_developmental_contribution_from UBERON:0008969 ! dental follicle relationship: part_of UBERON:0001708 ! jaw skeleton property_value: UBPROP:0000012 "in BTO, this is part of an embryo" xsd:string {external_ontology="BTO"} @@ -258467,7 +366436,6 @@ namespace: uberon def: "Anatomical line demarcating the boundary between forehead and scalp." [Wikipedia:Hairline] subset: pheno_slim xref: FMA:285412 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006800 ! anatomical line relationship: part_of UBERON:0000033 ! head @@ -258514,12 +366482,14 @@ synonym: "clivus ossis occipitalis" RELATED [FMA:75747] synonym: "occipital bone clivus" EXACT [FMA:75747] synonym: "Wackenheim's clivus line" RELATED [Wikipedia:Clivus_(anatomy)] xref: FMA:75747 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=674 xref: NCIT:C12494 +xref: neuronames:674 xref: SCTID:361736007 xref: UMLS:C0222724 {source="ncithesaurus:Clivus"} xref: Wikipedia:Clivus_(anatomy) is_a: UBERON:0005913 {source="FMA"} ! zone of bone organ +relationship: adjacent_to UBERON:0001677 ! sphenoid bone +relationship: located_in UBERON:0008788 ! posterior cranial fossa relationship: part_of UBERON:0001676 {source="FMA"} ! occipital bone property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c5/Clivus.png xsd:anyURI property_value: editor_note "check relationships." xsd:string @@ -258551,6 +366521,49 @@ relationship: connects UBERON:0000464 {minCardinality="2", maxCardinality="2"} ! relationship: has_part UBERON:0013686 ! anatomical conduit space property_value: UBPROP:0000012 "FMA has both conduit and conduit space. In EHDAA2 this is a surface feature" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0004113 +name: muscle of auditory ossicle +is_a: UBERON:0002376 ! cranial muscle +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: attaches_to UBERON:0001686 ! auditory ossicle bone +relationship: attaches_to UBERON:0001686 ! auditory ossicle bone +relationship: located_in UBERON:0004114 ! tympanic cavity +relationship: part_of UBERON:0001756 ! middle ear + +[Term] +id: UBERON:0004114 +name: tympanic cavity +is_a: BFO:0000141 ! immaterial entity +is_a: UBERON:0002553 ! anatomical cavity +is_a: UBERON:0005082 ! tube lumen +is_a: UBERON:0010064 ! open anatomical space +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0001756 ! middle ear +relationship: developmentally_replaces UBERON:0005625 ! tubotympanic recess lumen +relationship: luminal_space_of UBERON:0001756 ! middle ear +relationship: part_of UBERON:0001756 ! middle ear +relationship: surrounded_by UBERON:0010063 ! tympanic cavity epithelium +relationship: surrounds UBERON:0001686 ! auditory ossicle bone + +[Term] +id: UBERON:0004115 +name: blood vessel of tympanic cavity +is_a: UBERON:0003496 ! head blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: located_in UBERON:0004114 ! tympanic cavity +relationship: located_in UBERON:0004114 ! tympanic cavity +relationship: part_of UBERON:0001756 ! middle ear + +[Term] +id: UBERON:0004116 +name: nerve of tympanic cavity +is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: located_in UBERON:0004114 ! tympanic cavity +relationship: located_in UBERON:0004114 ! tympanic cavity +relationship: part_of UBERON:0001756 ! middle ear + [Term] id: UBERON:0004117 name: pharyngeal pouch @@ -258688,6 +366701,7 @@ is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: has_part UBERON:0000990 ! reproductive system intersection_of: has_part UBERON:0001008 ! renal system +relationship: develops_from UBERON:0003064 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="AAO", source="https://github.com/geneontology/go-ontology/issues/16143"} ! intermediate mesoderm relationship: existence_ends_during UBERON:0000066 ! fully formed stage relationship: has_part UBERON:0000990 ! reproductive system relationship: has_part UBERON:0001008 ! renal system @@ -258710,6 +366724,9 @@ synonym: "myocardium layer" EXACT [] xref: EMAPA:37475 {source="MA:th"} xref: MA:0000080 is_a: UBERON:0005983 ! heart layer +intersection_of: UBERON:0004923 ! organ component layer +intersection_of: layer_part_of UBERON:0002349 ! myocardium +relationship: layer_part_of UBERON:0002349 ! myocardium relationship: part_of UBERON:0002349 ! myocardium [Term] @@ -258731,6 +366748,11 @@ xref: MA:0002866 xref: TAO:0005059 xref: ZFA:0005059 is_a: UBERON:0004123 ! myocardial layer +intersection_of: UBERON:0004123 ! myocardial layer +intersection_of: adjacent_to UBERON:0002165 ! endocardium +intersection_of: composed_primarily_of GO:0036194 ! muscle cell projection +relationship: adjacent_to UBERON:0002165 ! endocardium +relationship: composed_primarily_of GO:0036194 ! muscle cell projection property_value: UBPROP:0000001 "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the the endocardium. Unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae of the zebrafish have more strut-like character, and are more uniform without apparent regional differences Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005059", ontology="TAO", source="ZFIN:curator"} [Term] @@ -258750,6 +366772,14 @@ synonym: "subepicardium layer" RELATED [MP:0004056] xref: MA:0002865 is_a: UBERON:0004123 ! myocardial layer +[Term] +id: UBERON:0004126 +name: trabecular layer of ventricle +is_a: UBERON:0004124 ! myocardium trabecular layer +intersection_of: UBERON:0004124 ! myocardium trabecular layer +intersection_of: part_of UBERON:0002082 ! cardiac ventricle +relationship: part_of UBERON:0001083 ! myocardium of ventricle + [Term] id: UBERON:0004127 name: compact layer of ventricle @@ -258796,6 +366826,7 @@ xref: VHOG:0000165 xref: Wikipedia:Optic_vesicles xref: XAO:0000228 xref: ZFA:0000050 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm @@ -258826,6 +366857,9 @@ xref: SCTID:360478008 xref: UMLS:C1707522 {source="ncithesaurus:Cortical_Cell_Layer_of_the_Cerebellum"} is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0016548 ! central nervous system gray matter layer +intersection_of: UBERON:0016548 ! central nervous system gray matter layer +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: contributes_to_morphology_of UBERON:0002129 ! cerebellar cortex relationship: part_of UBERON:0002129 ! cerebellar cortex [Term] @@ -258865,6 +366899,7 @@ id: UBERON:0004134 name: proximal tubule namespace: uberon def: "In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]." [GO:0072014] +subset: human_reference_atlas synonym: "kidney proximal tubule" EXACT [MA:0002611] synonym: "proximal kidney tubule" EXACT [MESH:A05.810.453.736.560.570] synonym: "renal proximal tubule" EXACT [] @@ -258874,7 +366909,10 @@ xref: EMAPA:28281 xref: MA:0002611 xref: MESH:D007687 is_a: UBERON:0006853 ! renal cortex tubule +relationship: continuous_with UBERON:0001230 ! glomerular capsule +relationship: continuous_with UBERON:0001289 ! descending limb of loop of Henle property_value: editor_note "TODO - ensure definition works across species." xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004135 @@ -258891,6 +366929,12 @@ xref: MESH:D007686 is_a: UBERON:0007685 ! region of nephron tubule property_value: RO:0002171 UBERON:0012424 +[Term] +id: UBERON:0004136 +name: intermediate tubule +is_a: UBERON:0007685 ! region of nephron tubule +relationship: part_of UBERON:0001288 ! loop of Henle + [Term] id: UBERON:0004139 name: cardiogenic plate @@ -258929,6 +366973,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage relationship: part_of UBERON:0003081 {source="GO:0003128"} ! lateral plate mesoderm +relationship: part_of UBERON:0036146 {source="https://orcid.org/0000-0003-3308-6245"} ! cardiopharyngeal field relationship: part_of UBERON:0036146 {source="BGEE:ann"} ! cardiopharyngeal field property_value: UBPROP:0000012 "this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]" xsd:string {external_ontology="GO"} @@ -259136,7 +367181,7 @@ xref: BIRNLEX:1049 xref: DHBA:10194 xref: EFO:0001990 xref: FMA:242003 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=91 +xref: neuronames:91 xref: UMLS:C0152301 {source="BIRNLEX:1049"} xref: Wikipedia:Orbitofrontal_cortex is_a: UBERON:0015593 ! frontal gyrus @@ -259163,9 +367208,9 @@ synonym: "white commissure" RELATED [MP:0009695] xref: BAMS:vc xref: EMAPA:37956 {source="MA:th"} xref: FMA:77035 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1641 xref: MBA:858 xref: NCIT:C33890 +xref: neuronames:1641 xref: SCTID:424149007 xref: UMLS:C1520137 {source="ncithesaurus:White_Commissure"} xref: Wikipedia:Anterior_white_commissure @@ -259203,6 +367248,7 @@ xref: FMA:45643 xref: http://www.snomedbrowser.com/Codes/Details/362207005 xref: SCTID:362207005 is_a: UBERON:0003133 ! reproductive organ +relationship: part_of UBERON:3011048 ! genital system [Term] id: UBERON:0004177 @@ -259293,6 +367339,8 @@ xref: EMAPA:35539 xref: MA:0002911 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003584 ! mammary gland connective tissue +intersection_of: UBERON:0001013 ! adipose tissue +intersection_of: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0004182 @@ -259305,10 +367353,38 @@ synonym: "mammary sprout" RELATED [] is_a: UBERON:0003244 ! epithelium of mammary gland is_a: UBERON:0005154 ! epithelial cord is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0005154 ! epithelial cord +intersection_of: part_of UBERON:0001765 ! mammary duct relationship: develops_from UBERON:0005333 ! mammary bud relationship: part_of UBERON:0001765 ! mammary duct property_value: UBPROP:0000008 "in female mouse embryos, the primary mammary cord (aka 'mammary sprout') is formed between E15.5 and E16.5; once the primary cord reaches the adipocytes of the fat pad (around E16), it begins to branch in a characteristic dichotomous fashion to form the initial ductal tree" xsd:string +[Term] +id: UBERON:0004183 +name: placental labyrinth blood vessel +namespace: uberon +def: "The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GO:0060716] +synonym: "blood vessel of labyrinthine layer" EXACT [OBOL:automatic] +synonym: "blood vessel of labyrinthine layer of placenta" EXACT [OBOL:automatic] +synonym: "blood vessel of placenta labyrinth" EXACT [OBOL:automatic] +synonym: "labyrinthine layer blood vessel" EXACT [GO:0060716] +synonym: "labyrinthine layer of placenta blood vessel" EXACT [OBOL:automatic] +synonym: "placenta labyrinth blood vessel" EXACT [OBOL:automatic] +is_a: UBERON:0022358 ! placenta blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0003946 ! placenta labyrinth +relationship: part_of UBERON:0003970 ! placental labyrinth vasculature + +[Term] +id: UBERON:0004184 +name: prostate gland stroma +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + [Term] id: UBERON:0004185 name: endodermal part of digestive tract @@ -259370,8 +367446,6 @@ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015153 ! medial gland of ocular region relationship: part_of UBERON:0000019 ! camera-type eye -property_value: RO:0002161 NCBITaxon:33554 {source="PMID:7559104"} -property_value: RO:0002161 NCBITaxon:9397 {source="PMID:7559104"} property_value: RO:0002161 NCBITaxon:9443 {source="PMID:7559104"} property_value: RO:0002161 NCBITaxon:9606 {notes="may be transient in embryos", source="PMID:7559104"} property_value: RO:0002161 NCBITaxon:9787 {source="PMID:7559104"} @@ -259395,6 +367469,7 @@ id: UBERON:0004188 name: glomerular epithelium namespace: uberon def: "The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GO:0072010] +subset: human_reference_atlas synonym: "epithelium of glomerulus" EXACT [] synonym: "epithelium of kidney glomerulus" EXACT [] synonym: "epithelium of renal glomerulus" EXACT [] @@ -259405,8 +367480,11 @@ xref: EMAPA:35458 xref: MA:0002847 is_a: UBERON:0004211 ! nephron epithelium is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus property_value: editor_note "TODO - check - GO says outer, BTO says inner. Make this a superclass" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004189 @@ -259418,6 +367496,8 @@ synonym: "renal glomerulus endothelium" EXACT [OBOL:automatic] xref: BTO:0004631 is_a: UBERON:0004188 ! glomerular epithelium is_a: UBERON:0004852 ! cardiovascular system endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0004190 ! renal glomerulus vasculature [Term] @@ -259425,19 +367505,24 @@ id: UBERON:0004190 name: renal glomerulus vasculature namespace: uberon def: "The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GO:0072012] +subset: human_reference_atlas synonym: "glomerulus vasculature" EXACT [OBOL:automatic] synonym: "renal glomerulus vascular network" EXACT [OBOL:automatic] synonym: "renal glomerulus vasculature" EXACT [OBOL:automatic] synonym: "vascular network of renal glomerulus" EXACT [OBOL:automatic] synonym: "vasculature of renal glomerulus" EXACT [OBOL:automatic] is_a: UBERON:0006544 ! kidney vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004193 name: loop of Henle ascending limb thin segment namespace: uberon def: "A sub-portion of the loop of Henle in the nephron of the kidney that is permeable to ions but not to water." [GO:0072021, Wikipedia:Thin_ascending_limb_of_loop_of_Henle] +subset: human_reference_atlas subset: pheno_slim synonym: "ascending limb thin segment of loop of Henle" EXACT [] synonym: "ascending thin limb" EXACT [FMA:17720] @@ -259454,6 +367539,7 @@ relationship: part_of UBERON:0003455 ! inner renal medulla loop of Henle relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI property_value: editor_note "check relationship to distal tubule" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004198 @@ -259492,6 +367578,7 @@ namespace: uberon alt_id: UBERON:0002449 alt_id: UBERON:0005098 def: "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GO:0072056, http://anatomy.uams.edu/anatomyhtml/kidney.html] +subset: human_reference_atlas subset: pheno_slim synonym: "Malphigian pyramid" RELATED MISSPELLING [BTO:0003926] synonym: "Malpighian pyramid" EXACT [Wikipedia:Renal_pyramids] @@ -259515,8 +367602,10 @@ xref: UMLS:C1514613 {source="ncithesaurus:Pyramid_of_Malpighi"} xref: Wikipedia:Renal_pyramids is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: contributes_to_morphology_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla -property_value: depicted:by Kidney:PioM.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "not the same as FMA:50609 Pyramid (which is a volume / dimensional entity)" xsd:string {external_ontology="FMA"} property_value: UBPROP:0000202 FMA:74268 @@ -259525,6 +367614,7 @@ id: UBERON:0004201 name: kidney outer medulla inner stripe namespace: uberon def: "The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thick and thin portions of nephron tubules." [GO:0072057] +subset: human_reference_atlas subset: pheno_slim synonym: "inner stripe" EXACT [GO:0072057] synonym: "inner stripe of medulla of kidney" EXACT [FMA:76663] @@ -259538,12 +367628,14 @@ xref: MA:0002626 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010000 ! multicellular anatomical structure relationship: part_of UBERON:0001293 ! outer medulla of kidney +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004202 name: kidney outer medulla outer stripe namespace: uberon def: "The outer stripe is the region of the kidney that lies distal to the line of termination of the straight renal tubules." [GO:0072058] +subset: human_reference_atlas subset: pheno_slim synonym: "outer medulla outer stripe" EXACT [MA:0002629] synonym: "outer stripe" EXACT [GO:0072058] @@ -259556,8 +367648,37 @@ xref: FMA:76662 xref: MA:0002629 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010000 ! multicellular anatomical structure +relationship: contributes_to_morphology_of UBERON:0001293 ! outer medulla of kidney +relationship: part_of UBERON:0001293 ! outer medulla of kidney +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004203 +name: cortical collecting duct +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0013522 ! subdivision of tube +intersection_of: UBERON:0013522 ! subdivision of tube +intersection_of: part_of UBERON:0001225 ! cortex of kidney +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule +relationship: part_of UBERON:0001225 ! cortex of kidney +relationship: part_of UBERON:0001232 ! collecting duct of renal tubule + +[Term] +id: UBERON:0004204 +name: outer medullary collecting duct +is_a: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: part_of UBERON:0001293 ! outer medulla of kidney relationship: part_of UBERON:0001293 ! outer medulla of kidney +[Term] +id: UBERON:0004205 +name: inner medullary collecting duct +is_a: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: part_of UBERON:0001294 ! inner medulla of kidney +relationship: part_of UBERON:0001294 ! inner medulla of kidney + [Term] id: UBERON:0004208 name: nephrogenic mesenchyme @@ -259566,7 +367687,11 @@ def: "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchy comment: The detailed events associated with the differentiation of the nephrogenic mesenchyme are somewhat complex. It has been suggested that each terminal branch of the ureteric bud stimulates the associated cap mesenchyme tissue to form a renal vesicle (the most primitive stage of nephron development: a stage I nephron). This then elongates, becomes a comma-shaped and then an S-shaped body (stage II nephron), and makes contact with and fuses with the distal component of the ureteric bud. The latter then forms the collecting duct. One fold of the S-shaped body gives rise to Bowman's capsule (also termed the glomerular capsule). Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus. The inner epithelial layer of the Bowman's capsule (also called the visceral epithelium, or podocyte layer because it consists of podocytes) is closely apposed to the endothelial glomerulus. Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle. The rest of the nephron elongates to form components of the proximal tubule, the loop of Henle and the distal tubule. The distal pole of the developing nephron connects to the ureteric bud that induced it at an early stage of nephron/ collecting duct development, before differentiation of the proximal tubule, the loop of Henle and the distal tubule are complete. This connection allows the excretory products produced by the kidney to be removed and subsequently transferred, via the ureter, into the bladder where they are stored until it is appropriate to empty the bladder. [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "mesenchyme of nephron" EXACT [OBOL:automatic] synonym: "nephron mesenchyme" EXACT [OBOL:automatic] +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: has_potential_to_develop_into UBERON:0001285 ! nephron +relationship: has_potential_to_develop_into UBERON:0001285 ! nephron [Term] id: UBERON:0004209 @@ -259574,9 +367699,11 @@ name: renal vesicle namespace: uberon def: "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GO:0072077] synonym: "stage I nephron" EXACT [http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html, ZFA:0005586] -is_a: CARO:0000000 ! anatomical entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle +relationship: developmentally_induced_by UBERON:0000084 ! ureteric bud relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme +relationship: has_potential_to_develop_into UBERON:0004211 ! nephron epithelium relationship: part_of UBERON:0010536 ! nephron progenitor property_value: editor_note "note that this class includes both metanephric and mesonephric vesicles - ZFA and EHDAA2 associations are placed with these classes. TODO - make a more specific develops_from relationship - see UBERON:0005107 ! metanephric cap" xsd:string @@ -259589,6 +367716,8 @@ synonym: "epithelial tissue of nephron" EXACT [OBOL:automatic] synonym: "epithelium of nephron" EXACT [OBOL:automatic] synonym: "nephron epithelial tissue" EXACT [OBOL:automatic] is_a: UBERON:0004819 ! kidney epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001285 ! nephron relationship: part_of UBERON:0001285 ! nephron [Term] @@ -259596,6 +367725,7 @@ id: UBERON:0004212 name: glomerular capillary namespace: uberon def: "The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus." [MGI:csmith, MP:0011320] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "blood capillary of renal glomerulus" EXACT [OBOL:automatic] @@ -259615,9 +367745,21 @@ xref: TAO:0005284 xref: UMLS:C0226356 {source="ncithesaurus:Glomerular_Capillary"} xref: ZFA:0005284 is_a: UBERON:0003527 ! kidney capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: part_of UBERON:0000074 ! renal glomerulus +relationship: contributes_to_morphology_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0004190 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! renal glomerulus vasculature +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Capillary that is part of the renal glomerulus. Glomerular capillary endothelial membranes in zebrafish normally have a fenestrated morphology that is visible at the ultrastructural level.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005284", ontology="TAO", source="ZFIN:ZDB-PUB-000824-1", source="ZFIN:curator"} +[Term] +id: UBERON:0004214 +name: upper leg nerve +is_a: UBERON:0003431 ! leg nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod +relationship: part_of UBERON:0000376 ! hindlimb stylopod + [Term] id: UBERON:0004215 name: back nerve @@ -259631,6 +367773,30 @@ intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum +[Term] +id: UBERON:0004216 +name: lower arm nerve +is_a: UBERON:0003433 ! arm nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: part_of UBERON:0002386 ! forelimb zeugopod + +[Term] +id: UBERON:0004217 +name: upper arm nerve +is_a: UBERON:0003433 ! arm nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0003822 ! forelimb stylopod +relationship: part_of UBERON:0003822 ! forelimb stylopod + +[Term] +id: UBERON:0004218 +name: lower leg nerve +is_a: UBERON:0003431 ! leg nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: part_of UBERON:0003823 ! hindlimb zeugopod + [Term] id: UBERON:0004219 name: urethra smooth muscle layer @@ -259669,6 +367835,7 @@ xref: MA:0001547 is_a: UBERON:0004221 ! intestine smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000059 ! large intestine +relationship: overlaps UBERON:0011198 {notes="consider merging"} ! muscle layer of large intestine relationship: part_of UBERON:0001169 {source="MA"} ! wall of large intestine property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} @@ -259706,6 +367873,7 @@ is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000160 ! intestine relationship: contributes_to_morphology_of UBERON:0000160 ! intestine +relationship: overlaps UBERON:0012367 {notes="consider merging"} ! muscle layer of intestine relationship: part_of UBERON:0001262 ! wall of intestine property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} @@ -259740,6 +367908,25 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0001167 ! wall of stomach +[Term] +id: UBERON:0004223 +name: vagina smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + +[Term] +id: UBERON:0004224 +name: muscular coat of vas deferens +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0006660 ! muscular coat +is_a: UBERON:0034933 ! layer of smooth muscle tissue +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0001000 ! vas deferens +relationship: part_of UBERON:0001000 ! vas deferens + [Term] id: UBERON:0004225 name: respiratory system smooth muscle @@ -259821,6 +368008,22 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder +[Term] +id: UBERON:0004229 +name: urinary bladder trigone smooth muscle +is_a: UBERON:0004228 ! urinary bladder smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder +relationship: part_of UBERON:0001257 ! trigone of urinary bladder + +[Term] +id: UBERON:0004230 +name: urinary bladder neck smooth muscle +is_a: UBERON:0004228 ! urinary bladder smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001258 ! neck of urinary bladder +relationship: part_of UBERON:0001258 ! neck of urinary bladder + [Term] id: UBERON:0004231 name: anal region smooth muscle @@ -259883,6 +368086,9 @@ xref: MA:0000751 xref: NCIT:C49260 xref: UMLS:C1708791 {source="ncithesaurus:Lymphatic_Vessel_Smooth_Muscle_Tissue"} is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001473 ! lymphatic vessel +relationship: contributes_to_morphology_of UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0001473 ! lymphatic vessel [Term] @@ -259928,6 +368134,15 @@ intersection_of: part_of UBERON:0001769 ! iris relationship: part_of UBERON:0001606 ! muscle of iris property_value: editor_note "see notes for muscle of iris." xsd:string +[Term] +id: UBERON:0004235 +name: mammary gland smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0001911 ! mammary gland + [Term] id: UBERON:0004236 name: arteriole smooth muscle @@ -259977,6 +368192,164 @@ intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001981 ! blood vessel property_value: UBPROP:0000009 "Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension." xsd:string +[Term] +id: UBERON:0004238 +name: spleen smooth muscle +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] +synonym: "involuntary muscle of spleen" EXACT [OBOL:automatic] +synonym: "non-striated muscle of spleen" EXACT [OBOL:automatic] +synonym: "smooth muscle of spleen" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of spleen" EXACT [OBOL:automatic] +synonym: "spleen involuntary muscle" EXACT [OBOL:automatic] +synonym: "spleen non-striated muscle" EXACT [OBOL:automatic] +synonym: "spleen smooth muscle tissue" EXACT [OBOL:automatic] +xref: EMAPA:35807 +xref: MA:0000757 +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002106 ! spleen +relationship: part_of UBERON:0002106 ! spleen + +[Term] +id: UBERON:0004239 +name: small intestine smooth muscle +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +subset: pheno_slim +synonym: "involuntary muscle of small bowel" EXACT [OBOL:automatic] +synonym: "involuntary muscle of small intestine" EXACT [OBOL:automatic] +synonym: "non-striated muscle of small bowel" EXACT [OBOL:automatic] +synonym: "non-striated muscle of small intestine" EXACT [OBOL:automatic] +synonym: "small bowel involuntary muscle" EXACT [OBOL:automatic] +synonym: "small bowel non-striated muscle" EXACT [OBOL:automatic] +synonym: "small bowel smooth muscle" EXACT [OBOL:automatic] +synonym: "small bowel smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "small intestine involuntary muscle" EXACT [OBOL:automatic] +synonym: "small intestine non-striated muscle" EXACT [OBOL:automatic] +synonym: "small intestine smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "smooth muscle of small bowel" EXACT [OBOL:automatic] +synonym: "smooth muscle of small intestine" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of small bowel" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of small intestine" EXACT [OBOL:automatic] +xref: EMAPA:35783 +xref: MA:0001559 +is_a: UBERON:0004221 ! intestine smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: overlaps UBERON:0011201 {notes="consider merging"} ! muscle layer of small intestine +relationship: part_of UBERON:0001168 ! wall of small intestine +property_value: UBPROP:0000012 "MA class may specifically mean muscle layer, but we treat as the sum of smooth muscle in both muscle layer and muscularis mucosa" xsd:string {external_ontology="MA"} + +[Term] +id: UBERON:0004240 +name: gall bladder smooth muscle +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +synonym: "biliary smooth muscle" RELATED [MA:0001635] +synonym: "gall bladder involuntary muscle" EXACT [OBOL:automatic] +synonym: "gall bladder non-striated muscle" EXACT [OBOL:automatic] +synonym: "gall bladder smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "gallbladder involuntary muscle" EXACT [OBOL:automatic] +synonym: "gallbladder non-striated muscle" EXACT [OBOL:automatic] +synonym: "gallbladder smooth muscle" EXACT [OBOL:automatic] +synonym: "gallbladder smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "involuntary muscle of gall bladder" EXACT [OBOL:automatic] +synonym: "involuntary muscle of gallbladder" EXACT [OBOL:automatic] +synonym: "non-striated muscle of gall bladder" EXACT [OBOL:automatic] +synonym: "non-striated muscle of gallbladder" EXACT [OBOL:automatic] +synonym: "smooth muscle of gall bladder" EXACT [OBOL:automatic] +synonym: "smooth muscle of gallbladder" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of gall bladder" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of gallbladder" EXACT [OBOL:automatic] +xref: EMAPA:35373 +xref: MA:0001635 +xref: NCIT:C49483 +xref: UMLS:C1708179 {source="ncithesaurus:Gallbladder_Smooth_Muscle_Tissue"} +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder + +[Term] +id: UBERON:0004241 +name: main bronchus smooth muscle +is_a: UBERON:0004242 ! bronchus smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + +[Term] +id: UBERON:0004242 +name: bronchus smooth muscle +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas +synonym: "bronchi involuntary muscle" EXACT [OBOL:automatic] +synonym: "bronchi non-striated muscle" EXACT [OBOL:automatic] +synonym: "bronchi smooth muscle" EXACT [OBOL:automatic] +synonym: "bronchi smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "bronchial smooth muscle" RELATED [EMAPA:35195] +synonym: "bronchial trunk involuntary muscle" EXACT [OBOL:automatic] +synonym: "bronchial trunk non-striated muscle" EXACT [OBOL:automatic] +synonym: "bronchial trunk smooth muscle" EXACT [OBOL:automatic] +synonym: "bronchial trunk smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "bronchus involuntary muscle" EXACT [OBOL:automatic] +synonym: "bronchus non-striated muscle" EXACT [OBOL:automatic] +synonym: "bronchus smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "involuntary muscle of bronchi" EXACT [OBOL:automatic] +synonym: "involuntary muscle of bronchial trunk" EXACT [OBOL:automatic] +synonym: "involuntary muscle of bronchus" EXACT [OBOL:automatic] +synonym: "non-striated muscle of bronchi" EXACT [OBOL:automatic] +synonym: "non-striated muscle of bronchial trunk" EXACT [OBOL:automatic] +synonym: "non-striated muscle of bronchus" EXACT [OBOL:automatic] +synonym: "smooth muscle of bronchi" EXACT [OBOL:automatic] +synonym: "smooth muscle of bronchial trunk" EXACT [OBOL:automatic] +synonym: "smooth muscle of bronchus" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of bronchi" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of bronchial trunk" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of bronchus" EXACT [OBOL:automatic] +xref: BTO:0004401 +xref: EMAPA:35195 +xref: MA:0001840 +xref: NCIT:C49213 +xref: UMLS:C1707055 {source="ncithesaurus:Bronchus_Smooth_Muscle_Tissue"} +is_a: UBERON:0004233 ! lower respiratory tract smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004243 +name: prostate gland smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0008715 ! muscle tissue of prostate +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0004245 +name: oviduct smooth muscle +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition]." [OBOL:automatic] +synonym: "fallopian tube involuntary muscle" EXACT [OBOL:automatic] +synonym: "fallopian tube non-striated muscle" EXACT [OBOL:automatic] +synonym: "fallopian tube smooth muscle" EXACT [OBOL:automatic] +synonym: "fallopian tube smooth muscle tissue" EXACT [OBOL:automatic] +synonym: "involuntary muscle of fallopian tube" EXACT [OBOL:automatic] +synonym: "non-striated muscle of fallopian tube" EXACT [OBOL:automatic] +synonym: "smooth muscle of fallopian tube" EXACT [OBOL:automatic] +synonym: "smooth muscle tissue of fallopian tube" EXACT [OBOL:automatic] +xref: EMAPA:29046 +xref: MA:0001721 +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 ! fallopian tube + [Term] id: UBERON:0004246 name: outflow tract smooth muscle @@ -260034,6 +368407,8 @@ synonym: "toe bone organ" EXACT [OBOL:automatic] xref: EMAPA:37309 {source="MA:th"} xref: MA:0000646 is_a: UBERON:0012359 ! pedal digitopodium bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:5101466 ! pedal digit digitopodial skeleton property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -260052,6 +368427,8 @@ synonym: "hand digit bone" NARROW SENSU [NCBITaxon:9606, OBOL:accepted] xref: EMAPA:37305 {source="MA:th"} xref: MA:0000622 is_a: UBERON:0012358 ! manual digitopodium bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:5102389 ! manual digit digitopodial skeleton property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -260066,6 +368443,8 @@ synonym: "humerus" NARROW [https://sourceforge.net/tracker/index.php?func=detail xref: EMAPA:35892 xref: MA:0000604 is_a: UBERON:0003460 ! arm bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0003822 ! forelimb stylopod relationship: part_of UBERON:0003822 ! forelimb stylopod property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -260152,6 +368531,8 @@ synonym: "zeugopod of lower extremity bone organ" EXACT [OBOL:automatic] xref: EMAPA:35519 xref: MA:0000676 is_a: UBERON:0005893 ! leg bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0003823 ! hindlimb zeugopod property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -260171,6 +368552,8 @@ xref: FMA:22470 xref: MA:0000684 xref: SCTID:245013005 is_a: UBERON:0001383 ! muscle of leg +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0004463 {source="prolog"} ! musculature of hindlimb stylopod [Term] @@ -260195,6 +368578,14 @@ relationship: part_of UBERON:0002416 ! integumental system property_value: editor_note "review as part of general integumentary system review - part of skin, or more generally, integumental system" xsd:string property_value: UBPROP:0000012 "in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only" xsd:string {external_ontology="MA"} +[Term] +id: UBERON:0004254 +name: forelimb zeugopod muscle +is_a: UBERON:0001499 ! muscle of arm +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: part_of UBERON:0004487 ! musculature of forelimb zeugopod + [Term] id: UBERON:0004255 name: forelimb stylopod muscle @@ -260211,6 +368602,8 @@ xref: FMA:37370 xref: MA:0000606 xref: SCTID:244979005 is_a: UBERON:0001499 ! muscle of arm +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0003822 ! forelimb stylopod relationship: part_of UBERON:0014791 {source="prolog"} ! musculature of forelimb stylopod property_value: editor_note "the FMA class 'muscle of arm' belongs here, do not move" xsd:string property_value: UBPROP:0000013 "See notes on UBERON:0001460 for possible terminological confusion over term 'arm'" xsd:string @@ -260229,10 +368622,20 @@ xref: FMA:22471 xref: MA:0000678 xref: SCTID:265806001 is_a: UBERON:0001383 ! muscle of leg +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0006067 {source="prolog"} ! musculature of hindlimb zeugopod property_value: editor_note "the FMA class 'muscle of leg' belongs here, do not move[cjm]" xsd:string property_value: UBPROP:0000013 "See notes on UBERON:0000978 for possible terminological confusion over term 'leg'" xsd:string +[Term] +id: UBERON:0004257 +name: upper leg blood vessel +is_a: UBERON:0003503 ! leg blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod +relationship: part_of UBERON:0000376 ! hindlimb stylopod + [Term] id: UBERON:0004258 name: back blood vessel @@ -260246,6 +368649,54 @@ intersection_of: UBERON:0001981 ! blood vessel intersection_of: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0001137 ! dorsum +[Term] +id: UBERON:0004259 +name: lower arm blood vessel +is_a: UBERON:0003507 ! arm blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: part_of UBERON:0002386 ! forelimb zeugopod + +[Term] +id: UBERON:0004260 +name: upper arm blood vessel +is_a: UBERON:0003507 ! arm blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0003822 ! forelimb stylopod +relationship: part_of UBERON:0003822 ! forelimb stylopod + +[Term] +id: UBERON:0004261 +name: lower leg blood vessel +is_a: UBERON:0003503 ! leg blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: part_of UBERON:0003823 ! hindlimb zeugopod + +[Term] +id: UBERON:0004262 +name: upper leg skin +is_a: UBERON:0001511 ! skin of leg +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod +relationship: part_of UBERON:0000376 ! hindlimb stylopod + +[Term] +id: UBERON:0004263 +name: upper arm skin +is_a: UBERON:0002427 ! arm skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0003822 ! forelimb stylopod +relationship: part_of UBERON:0003822 ! forelimb stylopod + +[Term] +id: UBERON:0004264 +name: lower leg skin +is_a: UBERON:0001511 ! skin of leg +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: part_of UBERON:0003823 ! hindlimb zeugopod + [Term] id: UBERON:0004265 name: outflow tract myocardium @@ -260278,6 +368729,8 @@ def: "A portion of connective tissue that is part of a hindlimb stylopod [Automa xref: EMAPA:37325 {source="MA:th"} xref: MA:0000683 is_a: UBERON:0003569 ! leg connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0000376 ! hindlimb stylopod relationship: transformation_of UBERON:0005254 ! upper leg mesenchyme @@ -260302,9 +368755,20 @@ def: "A portion of connective tissue that is part of a lower arm [Automatically xref: EMAPA:37319 {source="MA:th"} xref: MA:0000599 is_a: UBERON:0003573 ! arm connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod relationship: part_of UBERON:0002386 ! forelimb zeugopod relationship: transformation_of UBERON:0003327 ! mesenchyme of forearm +[Term] +id: UBERON:0004269 +name: upper arm connective tissue +is_a: UBERON:0003573 ! arm connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0003822 ! forelimb stylopod +relationship: part_of UBERON:0003822 ! forelimb stylopod +relationship: transformation_of UBERON:0005258 ! upper arm mesenchyme + [Term] id: UBERON:0004270 name: lower leg connective tissue @@ -260313,6 +368777,8 @@ def: "A portion of connective tissue that is part of a lower leg [Automatically xref: EMAPA:37327 {source="MA:th"} xref: MA:0000677 is_a: UBERON:0003569 ! leg connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0003823 ! hindlimb zeugopod relationship: transformation_of UBERON:0005259 ! lower leg mesenchyme @@ -260362,6 +368828,32 @@ intersection_of: UBERON:0003685 ! cranial suture intersection_of: part_of UBERON:0002213 ! cartilaginous joint relationship: part_of UBERON:0002213 ! cartilaginous joint +[Term] +id: UBERON:0004274 +name: lateral ventricle choroid plexus epithelium +is_a: UBERON:0003911 ! choroid plexus epithelium +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002307 ! choroid plexus of lateral ventricle +relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle + +[Term] +id: UBERON:0004275 +name: third ventricle choroid plexus epithelium +is_a: UBERON:0003911 ! choroid plexus epithelium +intersection_of: UBERON:0003911 ! choroid plexus epithelium +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002288 ! choroid plexus of third ventricle + +[Term] +id: UBERON:0004276 +name: fourth ventricle choroid plexus epithelium +is_a: UBERON:0003911 ! choroid plexus epithelium +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003911 ! choroid plexus epithelium +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle + [Term] id: UBERON:0004277 name: eye muscle @@ -260407,7 +368899,6 @@ xref: SCTID:361378004 xref: VSAO:0000026 xref: Wikipedia:Skeleton xref: XAO:0004053 -is_a: BFO:0000040 ! material entity is_a: UBERON:0034925 ! anatomical collection disjoint_from: UBERON:0004770 ! articular system relationship: has_member UBERON:0004765 ! skeletal element @@ -260518,6 +369009,7 @@ id: UBERON:0004294 name: glomerular capillary endothelium namespace: uberon def: "An endothelium that is part of a glomerular capillary." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "renal glomerulus capillary endothelium" EXACT [OBOL:automatic] xref: MA:0001658 @@ -260526,7 +369018,20 @@ xref: SCTID:243993006 xref: UMLS:C0227647 {source="ncithesaurus:Endothelium_of_the_Glomerular_Capillary"} is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004189 ! glomerular endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0004212 ! glomerular capillary +relationship: contributes_to_morphology_of UBERON:0004212 ! glomerular capillary relationship: part_of UBERON:0004212 ! glomerular capillary +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004296 +name: respiratory system lymphatic vessel smooth muscle +is_a: UBERON:0004225 ! respiratory system smooth muscle +is_a: UBERON:0004232 ! lymphatic vessel smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0003456 ! respiratory system lymphatic vessel +relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel [Term] id: UBERON:0004297 @@ -260558,7 +369063,10 @@ xref: MA:0002914 xref: SCTID:299711006 xref: Wikipedia:Distal_phalanges is_a: UBERON:0003221 ! phalanx +intersection_of: UBERON:0003221 ! phalanx +intersection_of: proximally_connected_to UBERON:0004301 ! middle phalanx relationship: part_of UBERON:0009551 ! distal segment of digit +relationship: proximally_connected_to UBERON:0004301 ! middle phalanx property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ab/Scheme_human_hand_bones-en.svg xsd:anyURI property_value: UBPROP:0000008 "In human anatomy, the distal phalanges of the four fingers and toes articulate proximally with the intermediate phalanges at the distal interphalangeal joints (DIP); in the thumb and big toe, with only two phalanges, the distal phalanges articulate proximally with the proximal phalanges. The distal phalanges carry and shape nails and claws and are therefore occasionally referred to as the ungual phalanges. The distal phalanges are cone-shaped in most mammals, including most primates, but relatively wide and flat in humans." xsd:string @@ -260578,6 +369086,11 @@ xref: MA:0002915 xref: SCTID:299710007 xref: Wikipedia:Intermediate_phalanges is_a: UBERON:0003221 ! phalanx +intersection_of: UBERON:0003221 ! phalanx +intersection_of: distally_connected_to UBERON:0003221 ! phalanx +intersection_of: proximally_connected_to UBERON:0003221 ! phalanx +relationship: distally_connected_to UBERON:0004300 ! distal phalanx +relationship: proximally_connected_to UBERON:0004302 ! proximal phalanx property_value: editor_note "consider using numbering system, and axioms to the effect that there is a single middle phalanx per finger in humans. This should perhaps be renamed 'intermediate phalanx', leaving the term middle phalanx open for the specific intermediate phalanx of a 3-phalanx digit" xsd:string property_value: UBPROP:0000008 "in some groups such as whales, there are multiple intermediate phalanges" xsd:string property_value: UBPROP:0000008 "Intermediate phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones of the finger and toe which lie in the middle, between the two wrinkly joints. The thumb and big toe do not have intermediate phalanges. In most other vertebrates, they have a corresponding place in their limbs, whether they be paw, wing, hoof or fin" xsd:string {source="WP"} @@ -260596,6 +369109,9 @@ xref: MA:0002916 xref: SCTID:299708005 xref: Wikipedia:Proximal_phalanges is_a: UBERON:0003221 ! phalanx +intersection_of: UBERON:0003221 ! phalanx +intersection_of: connected_to UBERON:0003821 ! metapodium bone +relationship: connected_to UBERON:0003821 ! metapodium bone property_value: UBPROP:0000008 "Proximal phalanges are bones found in the limbs of most vertebrates. In humans, they are the bones at the base of a toe or finger, the prominent, knobby ends of which are often called the knuckles. In other vertebrates, proximal phalanges have a similar placement in the corresponding limbs, be they paw, wing or fin. In many species, they are the longest and thickest phalanx ('finger' bone)" xsd:string {source="WP"} property_value: UBPROP:0000105 "1" xsd:nonNegativeInteger @@ -260698,6 +369214,8 @@ xref: SCTID:361790004 is_a: UBERON:0003639 ! manual digit 5 phalanx is_a: UBERON:0003865 ! distal phalanx of manus is_a: UBERON:0014487 ! distal phalanx of digit 5 +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0003625 ! manual digit 5 [Term] id: UBERON:0004315 @@ -260719,6 +369237,8 @@ xref: SCTID:361799003 is_a: UBERON:0003640 ! pedal digit 1 phalanx is_a: UBERON:0003867 ! distal phalanx of pes is_a: UBERON:0014483 ! distal phalanx of digit 1 +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0003631 ! pedal digit 1 [Term] id: UBERON:0004316 @@ -260813,6 +369333,8 @@ xref: SCTID:244674003 is_a: UBERON:0003863 ! pedal digit 5 phalanx is_a: UBERON:0003867 ! distal phalanx of pes is_a: UBERON:0014487 ! distal phalanx of digit 5 +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0003635 ! pedal digit 5 [Term] id: UBERON:0004320 @@ -260940,6 +369462,8 @@ xref: SCTID:263410009 is_a: UBERON:0003639 ! manual digit 5 phalanx is_a: UBERON:0003864 ! middle phalanx of manus is_a: UBERON:0014491 ! middle phalanx of digit 5 +intersection_of: UBERON:0004301 ! middle phalanx +intersection_of: part_of UBERON:0003625 ! manual digit 5 [Term] id: UBERON:0004324 @@ -261042,6 +369566,8 @@ xref: SCTID:244673009 is_a: UBERON:0003863 ! pedal digit 5 phalanx is_a: UBERON:0003866 ! middle phalanx of pes is_a: UBERON:0014491 ! middle phalanx of digit 5 +intersection_of: UBERON:0004301 ! middle phalanx +intersection_of: part_of UBERON:0003635 ! pedal digit 5 [Term] id: UBERON:0004328 @@ -261143,6 +369669,9 @@ xref: SCTID:263406006 is_a: UBERON:0002234 ! proximal phalanx of manus is_a: UBERON:0003639 ! manual digit 5 phalanx is_a: UBERON:0014505 ! proximal phalanx of digit 5 +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0003625 ! manual digit 5 +relationship: proximally_connected_to UBERON:0003649 ! metacarpal bone of digit 5 [Term] id: UBERON:0004332 @@ -261165,6 +369694,9 @@ xref: SCTID:182150003 is_a: UBERON:0003640 ! pedal digit 1 phalanx is_a: UBERON:0003868 ! proximal phalanx of pes is_a: UBERON:0014501 ! proximal phalanx of digit 1 +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0003631 ! pedal digit 1 +relationship: proximally_connected_to UBERON:0003650 ! metatarsal bone of digit 1 [Term] id: UBERON:0004333 @@ -261260,6 +369792,9 @@ xref: SCTID:244672004 is_a: UBERON:0003863 ! pedal digit 5 phalanx is_a: UBERON:0003868 ! proximal phalanx of pes is_a: UBERON:0014505 ! proximal phalanx of digit 5 +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0003635 ! pedal digit 5 +relationship: proximally_connected_to UBERON:0003654 ! metatarsal bone of digit 5 [Term] id: UBERON:0004337 @@ -261280,6 +369815,8 @@ xref: SCTID:182007006 is_a: UBERON:0003620 ! manual digit 1 phalanx is_a: UBERON:0003865 ! distal phalanx of manus is_a: UBERON:0014483 ! distal phalanx of digit 1 +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0001463 ! manual digit 1 property_value: UBPROP:0000008 "The human pollical distal phalanx (PDP) has a pronounced insertion for the flexor pollicis longus (asymmetric towards the radial side), an ungual fossa, and a pair of dissymmetric ungual spines (the ulnar being more prominent). This asymmetry is necessary to ensure that the thumb pulp is always facing the pulps of the other digits, an osteological configuration which provides the maximum contact surface with held objects." xsd:string {source="WP"} [Term] @@ -261300,6 +369837,9 @@ xref: SCTID:181992006 is_a: UBERON:0002234 ! proximal phalanx of manus is_a: UBERON:0003620 ! manual digit 1 phalanx is_a: UBERON:0014501 ! proximal phalanx of digit 1 +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0001463 ! manual digit 1 +relationship: proximally_connected_to UBERON:0003645 ! metacarpal bone of digit 1 [Term] id: UBERON:0004339 @@ -261342,7 +369882,7 @@ xref: BTO:0000474 xref: EHDAA2:0001504 xref: EMAPA:16107 xref: EMAPA_RETIRED:16084 -xref: MESH:A16.254.403.147 +xref: MESH:D000482 xref: NCIT:C34101 xref: RETIRED_EHDAA2:0000114 xref: SCTID:308825007 @@ -261351,6 +369891,10 @@ xref: VHOG:0000738 xref: Wikipedia:Allantois is_a: UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0000162 {source="Hymans"} ! cloaca +relationship: has_developmental_contribution_from UBERON:0000925 {notes="hindgut diverticulum endoderm", source="ISBN:0073040584"} ! endoderm +relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm +relationship: only_in_taxon NCBITaxon:32524 {source="Hymans"} ! Amniota +relationship: overlaps UBERON:0001008 {source="EHDAA2-modified"} ! renal system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray25.png xsd:anyURI property_value: UBPROP:0000001 "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000738", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/allantois"} property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000738", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"} @@ -261373,6 +369917,7 @@ xref: EMAPA:16072 xref: FMA:293110 xref: http://linkedlifedata.com/resource/umls/id/C0033153 xref: http://www.snomedbrowser.com/Codes/Details/361438007 +xref: MESH:D054240 xref: NCIT:C28402 xref: Primitive:streak xref: SCTID:361438007 @@ -261429,6 +369974,7 @@ xref: VHOG:0000979 is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: develops_from UBERON:0000085 {source="EHDAA2"} ! morula +relationship: has_part CL:1000274 ! trophectodermal cell relationship: part_of UBERON:0005631 {source="EHDAA2"} ! extraembryonic membrane property_value: editor_note "distinction between trophectoderm and trophoblast unclear/inconsistent in many sources" xsd:string property_value: UBPROP:0000001 "The outer cellular layer of the mammalian blastocyst. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.750, see_Kardong_KV][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000979", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -261450,10 +369996,12 @@ synonym: "gubernaculum" EXACT [http://orcid.org/0000-0002-6601-2165] xref: NCIT:C82952 xref: UMLS:C0228051 {source="ncithesaurus:Gubernaculum_Testis"} xref: Wikipedia:Gubernaculum +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005172 ! abdomen element is_a: UBERON:0008845 {source="MP"} ! nonskeletal ligament +relationship: attaches_to UBERON:0000991 ! gonad relationship: develops_from UBERON:0003064 {source="Wikipedia"} ! intermediate mesoderm relationship: part_of UBERON:0000323 {source="BTO"} ! late embryo relationship: part_of UBERON:0002358 ! peritoneum @@ -261482,14 +370030,17 @@ xref: GAID:1307 xref: http://linkedlifedata.com/resource/umls/id/C0282505 xref: Limb:bud xref: MESH:A16.254.462 +xref: MESH:D018878 xref: NCIT:C34203 xref: UMLS:C0282505 {source="ncithesaurus:Limb_Bud"} xref: Wikipedia:Limb_bud xref: XAO:0003161 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004357 ! paired limb/fin bud relationship: developmentally_induced_by UBERON:0003081 {source="ISBN:9780878932504"} ! lateral plate mesoderm relationship: has_developmental_contribution_from UBERON:0005733 ! limb field relationship: has_potential_to_develop_into UBERON:0002101 ! limb +relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda property_value: UBPROP:0000001 "Early outgrowth of presumptive limb.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010375", ontology="AAO", source="AAO:EJS"} [Term] @@ -261557,11 +370108,14 @@ xref: UMLS:C1516037 {source="ncithesaurus:Apical_Ectodermal_Ridge"} xref: Wikipedia:Apical_ectodermal_ridge xref: XAO:0004121 xref: ZFA:0001702 -is_a: CARO:0000000 ! anatomical entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002050 ! embryonic structure +relationship: capable_of GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: capable_of GO:0061037 ! negative regulation of cartilage development relationship: developmentally_induced_by UBERON:0003104 ! mesenchyme relationship: part_of UBERON:0000924 ! ectoderm relationship: part_of UBERON:0004357 ! paired limb/fin bud +relationship: produces PR:000007499 ! fibroblast growth factor 8 property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg xsd:anyURI property_value: IAO:0000232 "note that media, dorsal fins etc have AERs." xsd:string property_value: UBPROP:0000001 "Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010760", ontology="AAO", source="AAO:EJS"} @@ -261806,6 +370360,9 @@ def: "Blood vessel that is connected to the yolk sac." [http://orcid.org/0000-00 subset: pheno_slim xref: EMAPA:36494 is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: connected_to UBERON:0001040 ! yolk sac +relationship: connected_to UBERON:0001040 ! yolk sac relationship: part_of UBERON:0004374 ! vitelline vasculature [Term] @@ -261925,6 +370482,7 @@ xref: TAO:0002155 xref: UMLS:C0229127 {source="ncithesaurus:Bowman_s_Membrane"} xref: Wikipedia:Bowman%27s_membrane xref: ZFA:0001684 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0005769 ! basement membrane of epithelium is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -261946,6 +370504,9 @@ synonym: "vitelline bloos vessel system" RELATED [https://orcid.org/0000-0002-66 synonym: "vitelline system" RELATED [https://orcid.org/0000-0002-6601-2165] xref: Wikipedia:Vitelline_circulation is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: connected_to UBERON:0001040 ! yolk sac +relationship: connected_to UBERON:0001040 ! yolk sac [Term] id: UBERON:0004375 @@ -261970,6 +370531,9 @@ def: "A metaphysis that is in the distal side of a diaphysis." [OBOL:automatic] synonym: "distal diaphyseal end of long bone" EXACT [FMA:32824] xref: FMA:32824 is_a: UBERON:0001438 ! metaphysis +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: in_distal_side_of UBERON:0004769 ! diaphysis +relationship: in_distal_side_of UBERON:0004769 ! diaphysis [Term] id: UBERON:0004378 @@ -261979,6 +370543,9 @@ def: "A metaphysis that is in the proximal side of a diaphysis." [OBOL:automatic synonym: "proximal diaphyseal end of long bone" EXACT [FMA:32823] xref: FMA:32823 is_a: UBERON:0001438 ! metaphysis +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: in_proximal_side_of UBERON:0004769 ! diaphysis +relationship: in_proximal_side_of UBERON:0004769 ! diaphysis [Term] id: UBERON:0004379 @@ -261989,6 +370556,10 @@ synonym: "distal end of long bone" EXACT [FMA:32822] xref: FMA:32822 xref: SCTID:279999006 is_a: UBERON:0001437 ! epiphysis +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: in_distal_side_of UBERON:0001474 ! bone element +relationship: adjacent_to UBERON:0004377 ! distal metaphysis +relationship: in_distal_side_of UBERON:0001474 ! bone element [Term] id: UBERON:0004380 @@ -261999,6 +370570,10 @@ synonym: "proximal end of long bone" EXACT [FMA:32821] xref: FMA:32821 xref: SCTID:279998003 is_a: UBERON:0001437 ! epiphysis +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: in_proximal_side_of UBERON:0001474 ! bone element +relationship: adjacent_to UBERON:0004378 ! proximal metaphysis +relationship: in_proximal_side_of UBERON:0001474 ! bone element [Term] id: UBERON:0004381 @@ -262030,6 +370605,8 @@ xref: FMA:32825 xref: SCTID:313054009 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0000976 ! humerus relationship: part_of UBERON:0000976 ! humerus [Term] @@ -262045,6 +370622,8 @@ xref: MA:0003113 xref: SCTID:314626006 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0000979 ! tibia relationship: part_of UBERON:0000979 ! tibia [Term] @@ -262060,6 +370639,8 @@ xref: MA:0003056 xref: SCTID:314625005 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0000981 ! femur [Term] @@ -262073,6 +370654,8 @@ xref: FMA:33770 xref: SCTID:313055005 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0001423 ! radius bone relationship: part_of UBERON:0001423 ! radius bone [Term] @@ -262086,6 +370669,8 @@ xref: FMA:33748 xref: SCTID:313056006 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0001424 ! ulna relationship: part_of UBERON:0001424 ! ulna [Term] @@ -262099,6 +370684,8 @@ synonym: "epiphysis of phalanx of hand" RELATED [FMA:240707] xref: FMA:240707 xref: SCTID:314620000 is_a: UBERON:0004446 ! epiphysis of phalanx +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0001436 ! phalanx of manus relationship: part_of UBERON:0001436 ! phalanx of manus [Term] @@ -262111,6 +370698,8 @@ synonym: "fibula epiphysis" EXACT [FMA:33726] xref: FMA:33726 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0001446 ! fibula relationship: part_of UBERON:0001446 ! fibula [Term] @@ -262126,6 +370715,8 @@ xref: FMA:33814 xref: SCTID:313057002 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0001448 ! metatarsal bone relationship: part_of UBERON:0001448 ! metatarsal bone [Term] @@ -262141,6 +370732,8 @@ xref: FMA:33792 xref: SCTID:314907001 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0002374 ! metacarpal bone relationship: part_of UBERON:0002374 ! metacarpal bone [Term] @@ -262153,6 +370746,8 @@ synonym: "first metacarpal bone epiphysis" EXACT [FMA:33793] synonym: "metacarpal 1 epiphysis" EXACT [] xref: FMA:33793 is_a: UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003645 ! metacarpal bone of digit 1 relationship: part_of UBERON:0003645 ! metacarpal bone of digit 1 [Term] @@ -262165,8 +370760,50 @@ synonym: "first metatarsal bone epiphysis" EXACT [FMA:33815] synonym: "metatarsal 1 epiphysis" EXACT [] xref: FMA:33815 is_a: UBERON:0004389 ! epiphysis of metatarsal bone +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003650 ! metatarsal bone of digit 1 relationship: part_of UBERON:0003650 ! metatarsal bone of digit 1 +[Term] +id: UBERON:0004399 +name: epiphysis of fifth metatarsal bone +is_a: UBERON:0004389 ! epiphysis of metatarsal bone +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003654 ! metatarsal bone of digit 5 +relationship: part_of UBERON:0003654 ! metatarsal bone of digit 5 + +[Term] +id: UBERON:0004400 +name: bone tissue of epiphysis +is_a: UBERON:0005808 ! bone tissue of long bone +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0001437 ! epiphysis +relationship: part_of UBERON:0001437 ! epiphysis + +[Term] +id: UBERON:0004401 +name: bone tissue of distal epiphysis +is_a: UBERON:0004400 ! bone tissue of epiphysis +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0004379 ! distal epiphysis +relationship: part_of UBERON:0004379 ! distal epiphysis + +[Term] +id: UBERON:0004402 +name: bone tissue of proximal epiphysis +is_a: UBERON:0004400 ! bone tissue of epiphysis +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0004380 ! proximal epiphysis +relationship: part_of UBERON:0004380 ! proximal epiphysis + +[Term] +id: UBERON:0004403 +name: periosteum of epiphysis +is_a: UBERON:0016896 ! periosteum of long bone +intersection_of: UBERON:0002515 ! periosteum +intersection_of: part_of UBERON:0001437 ! epiphysis +relationship: part_of UBERON:0001437 ! epiphysis + [Term] id: UBERON:0004404 name: distal epiphysis of humerus @@ -262179,6 +370816,8 @@ xref: FMA:32826 xref: SCTID:310655007 is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004382 ! epiphysis of humerus +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0000976 ! humerus [Term] id: UBERON:0004405 @@ -262193,6 +370832,8 @@ xref: SCTID:302527001 xref: Wikipedia:Lower_extremity_of_tibia is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004383 ! epiphysis of tibia +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0000979 ! tibia [Term] id: UBERON:0004406 @@ -262207,6 +370848,8 @@ xref: FMA:32844 xref: SCTID:280016000 is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004384 ! epiphysis of femur +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0000981 ! femur property_value: UBPROP:0000001 "Head of the femur that articulates with the tibia and fibula.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000893", ontology="AAO", source="AAO:LAP"} [Term] @@ -262222,6 +370865,8 @@ xref: SCTID:280013008 xref: Wikipedia:Lower_extremity_of_radius is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004385 ! epiphysis of radius +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0001423 ! radius bone [Term] id: UBERON:0004408 @@ -262235,6 +370880,16 @@ xref: FMA:33754 xref: SCTID:302521000 is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004386 ! epiphysis of ulna +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0001424 ! ulna + +[Term] +id: UBERON:0004409 +name: distal epiphysis of phalanx of manus +is_a: UBERON:0004387 ! epiphysis of phalanx of manus +is_a: UBERON:0004448 ! distal epiphysis of phalanx +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0001436 ! phalanx of manus [Term] id: UBERON:0004410 @@ -262249,6 +370904,8 @@ xref: SCTID:129111008 xref: SCTID:280018004 is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004388 ! epiphysis of fibula +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0001446 ! fibula [Term] id: UBERON:0004411 @@ -262268,6 +370925,8 @@ xref: SCTID:280028008 xref: Wikipedia:Upper_extremity_of_humerus is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004382 ! epiphysis of humerus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0000976 ! humerus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray207.png xsd:anyURI [Term] @@ -262282,6 +370941,8 @@ xref: FMA:32841 xref: SCTID:244702009 is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004384 ! epiphysis of femur +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0000981 ! femur [Term] id: UBERON:0004413 @@ -262297,6 +370958,125 @@ xref: SCTID:280029000 xref: Wikipedia:Upper_extremity_of_radius is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004385 ! epiphysis of radius +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001423 ! radius bone + +[Term] +id: UBERON:0004414 +name: proximal epiphysis of phalanx of manus +is_a: UBERON:0004387 ! epiphysis of phalanx of manus +is_a: UBERON:0004447 ! proximal epiphysis of phalanx +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001436 ! phalanx of manus + +[Term] +id: UBERON:0004415 +name: proximal epiphysis of metatarsal bone +is_a: UBERON:0004380 ! proximal epiphysis +is_a: UBERON:0004389 ! epiphysis of metatarsal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001448 ! metatarsal bone + +[Term] +id: UBERON:0004416 +name: proximal epiphysis of metacarpal bone +is_a: UBERON:0004380 ! proximal epiphysis +is_a: UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0002374 ! metacarpal bone + +[Term] +id: UBERON:0004417 +name: proximal epiphysis of phalanx of manual digit 1 +is_a: UBERON:0004414 ! proximal epiphysis of phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003620 ! manual digit 1 phalanx +relationship: part_of UBERON:0003620 ! manual digit 1 phalanx + +[Term] +id: UBERON:0004421 +name: proximal epiphysis of phalanx of manual digit 5 +is_a: UBERON:0004414 ! proximal epiphysis of phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003639 ! manual digit 5 phalanx +relationship: part_of UBERON:0003639 ! manual digit 5 phalanx + +[Term] +id: UBERON:0004422 +name: proximal epiphysis of first metacarpal bone +is_a: UBERON:0004391 ! epiphysis of first metacarpal bone +is_a: UBERON:0004416 ! proximal epiphysis of metacarpal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003645 ! metacarpal bone of digit 1 + +[Term] +id: UBERON:0004426 +name: proximal epiphysis of fifth metacarpal bone +is_a: UBERON:0004416 ! proximal epiphysis of metacarpal bone +is_a: UBERON:0011104 ! epiphysis of fifth metacarpal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003649 ! metacarpal bone of digit 5 + +[Term] +id: UBERON:0004427 +name: proximal epiphysis of first metatarsal bone +is_a: UBERON:0004395 ! epiphysis of first metatarsal bone +is_a: UBERON:0004415 ! proximal epiphysis of metatarsal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003650 ! metatarsal bone of digit 1 + +[Term] +id: UBERON:0004431 +name: proximal epiphysis of fifth metatarsal bone +is_a: UBERON:0004399 ! epiphysis of fifth metatarsal bone +is_a: UBERON:0004415 ! proximal epiphysis of metatarsal bone +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003654 ! metatarsal bone of digit 5 + +[Term] +id: UBERON:0004435 +name: proximal epiphysis of distal phalanx of manual digit 5 +is_a: UBERON:0004421 ! proximal epiphysis of phalanx of manual digit 5 +is_a: UBERON:0011979 ! epiphysis of distal phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0004314 ! distal phalanx of manual digit 5 +relationship: part_of UBERON:0004314 ! distal phalanx of manual digit 5 + +[Term] +id: UBERON:0004439 +name: proximal epiphysis of middle phalanx of manual digit 5 +is_a: UBERON:0004421 ! proximal epiphysis of phalanx of manual digit 5 +is_a: UBERON:0011978 ! epiphysis of middle phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0004323 ! middle phalanx of manual digit 5 +relationship: part_of UBERON:0004323 ! middle phalanx of manual digit 5 + +[Term] +id: UBERON:0004443 +name: proximal epiphysis of proximal phalanx of manual digit 5 +is_a: UBERON:0004421 ! proximal epiphysis of phalanx of manual digit 5 +is_a: UBERON:0011977 ! epiphysis of proximal phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0004331 ! proximal phalanx of manual digit 5 +relationship: part_of UBERON:0004331 ! proximal phalanx of manual digit 5 + +[Term] +id: UBERON:0004444 +name: proximal epiphysis of distal phalanx of manual digit 1 +is_a: UBERON:0004417 ! proximal epiphysis of phalanx of manual digit 1 +is_a: UBERON:0011979 ! epiphysis of distal phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0004337 ! distal phalanx of manual digit 1 +relationship: part_of UBERON:0004337 ! distal phalanx of manual digit 1 + +[Term] +id: UBERON:0004445 +name: proximal epiphysis of proximal phalanx of manual digit 1 +is_a: UBERON:0004417 ! proximal epiphysis of phalanx of manual digit 1 +is_a: UBERON:0011977 ! epiphysis of proximal phalanx of manus +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0004338 ! proximal phalanx of manual digit 1 +relationship: part_of UBERON:0004338 ! proximal phalanx of manual digit 1 [Term] id: UBERON:0004446 @@ -262307,8 +371087,26 @@ subset: pheno_slim xref: SCTID:280033007 is_a: UBERON:0001437 ! epiphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003221 ! phalanx relationship: part_of UBERON:0003221 ! phalanx +[Term] +id: UBERON:0004447 +name: proximal epiphysis of phalanx +is_a: UBERON:0004380 ! proximal epiphysis +is_a: UBERON:0004446 ! epiphysis of phalanx +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0003221 ! phalanx + +[Term] +id: UBERON:0004448 +name: distal epiphysis of phalanx +is_a: UBERON:0004379 ! distal epiphysis +is_a: UBERON:0004446 ! epiphysis of phalanx +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0003221 ! phalanx + [Term] id: UBERON:0004449 name: cerebral artery @@ -262349,6 +371147,11 @@ xref: EMAPA:37722 {source="MA:th"} xref: MA:0002869 xref: XAO:0003077 is_a: UBERON:0002412 ! vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: anterior_to UBERON:0001095 ! caudal vertebra +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0011677 ! trunk vertebra +relationship: anterior_to UBERON:0001095 ! caudal vertebra property_value: UBPROP:0000008 "In humans, there are 24 presacral vertebrae (7 cervical, 12 thoracic, and 5 lumbar)" xsd:string property_value: UBPROP:0000012 "it's not clear if the XAO class belongs here or below" xsd:string {external_ontology="XAO"} @@ -262387,9 +371190,14 @@ xref: SCTID:361289009 xref: Wikipedia:Wrist is_a: UBERON:0006716 ! mesopodium region is_a: UBERON:0008785 {source="FMA"} ! upper limb segment +intersection_of: UBERON:0006716 ! mesopodium region +intersection_of: part_of UBERON:0002398 ! manus +relationship: distally_connected_to UBERON:0004453 ! metacarpus region +relationship: has_skeleton UBERON:0009880 ! carpal skeleton relationship: part_of UBERON:0002398 ! manus -property_value: depicted:by Hand:parts.jpg xsd:anyURI -property_value: depicted:by Human:wrist.png xsd:anyURI +relationship: proximally_connected_to UBERON:0002386 ! forelimb zeugopod +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg xsd:anyURI [Term] id: UBERON:0004453 @@ -262411,8 +371219,11 @@ xref: MA:0000042 xref: SCTID:370638006 is_a: UBERON:0005451 {source="FMA"} ! segment of manus is_a: UBERON:0009877 ! metapodium region +intersection_of: UBERON:0009877 ! metapodium region +intersection_of: part_of UBERON:0002398 ! manus +relationship: has_skeleton UBERON:0010544 ! metacarpus skeleton relationship: part_of UBERON:0012141 {source="PHENOSCAPE:ni"} ! manual digitopodium region -property_value: depicted:by Metacarpals:numbered-en.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg xsd:anyURI property_value: editor_note "Note that along with FMA we treat this as a limb segment rather than a purely skeletal element" xsd:string property_value: UBPROP:0000007 "metacarpal" xsd:string property_value: UBPROP:0000012 "Note that mammalian and non-mammalian AOs differ in whether they consider this a part of the skeleton" xsd:string @@ -262440,15 +371251,20 @@ xref: FMA:9665 xref: GAID:41 xref: galen:Ankle xref: MA:0000043 -xref: MESH:A01.378.610.250.149 -xref: MESH:A13.473.821 +xref: MESH:D000842 xref: OpenCyc:Mx4rvVi-R5wpEbGdrcN5Y29ycA xref: SCTID:361292008 xref: Wikipedia:Ankle is_a: UBERON:0006716 ! mesopodium region is_a: UBERON:0008784 ! lower limb segment +intersection_of: UBERON:0006716 ! mesopodium region +intersection_of: part_of UBERON:0002387 ! pes +disjoint_from: UBERON:0004772 ! eyelid tarsus +relationship: distally_connected_to UBERON:0000983 ! metatarsus region +relationship: has_skeleton UBERON:0009879 ! tarsal skeleton relationship: part_of UBERON:0002387 ! pes -property_value: depicted:by Ankle:en.svg xsd:anyURI +relationship: proximally_connected_to UBERON:0003823 ! hindlimb zeugopod +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg xsd:anyURI property_value: IAO:0000232 "this term refers to the limb segment. See also: tarsal bones and tarsal skeleton" xsd:string property_value: UBPROP:0000012 "MA has both tarsus (part of foot, has tarsal bone) and ankle (part of hindlimb, has joint, nerve, skin)." xsd:string {external_ontology="MA"} @@ -262499,6 +371315,7 @@ synonym: "musculi capitis" EXACT LATIN [FMA:71287, FMA:TA] synonym: "set of muscles of head" EXACT [FMA:71287] xref: EMAPA:18171 xref: FMA:71287 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: attaches_to UBERON:0003129 ! skull @@ -262540,6 +371357,8 @@ synonym: "set of muscles of thigh" EXACT [FMA:50208] synonym: "thigh musculature" EXACT [FMA:50208] xref: FMA:50208 is_a: UBERON:0004466 ! musculature of leg +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0000376 ! hindlimb stylopod [Term] @@ -262593,6 +371412,8 @@ def: "Any collection of muscles that is part of a lower leg or upper leg [Automa synonym: "leg muscle system" EXACT [EHDAA2:0000973] xref: EHDAA2:0000973 is_a: UBERON:0004482 ! musculature of lower limb +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0000978 ! leg relationship: part_of UBERON:0000978 ! leg property_value: UBPROP:0000013 "see notes on UBERON:0000978 for possible confusion over the term 'leg'. This class represents the class-union of upper leg musculature and lower leg musculature (and thus may not mean precisely the same thing as the EHDAA2 class)" xsd:string @@ -262609,6 +371430,16 @@ xref: FMA:264609 xref: TAO:0001307 xref: ZFA:0001307 is_a: UBERON:0001015 ! musculature +relationship: overlaps UBERON:0001042 ! chordate pharynx + +[Term] +id: UBERON:0004468 +name: set of muscles of vertebral column +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0001015 ! musculature +intersection_of: UBERON:0001015 ! musculature +intersection_of: attaches_to UBERON:0001130 ! vertebral column +relationship: attaches_to UBERON:0001130 ! vertebral column [Term] id: UBERON:0004469 @@ -262702,8 +371533,20 @@ synonym: "muscle group of arm" EXACT [FMA:50202] synonym: "set of muscles of arm" EXACT [FMA:50202] xref: EHDAA2:0000141 is_a: UBERON:0004481 ! musculature of upper limb +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0001460 ! arm relationship: part_of UBERON:0001460 ! arm +[Term] +id: UBERON:0004475 +name: musculature of hip +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0001015 ! musculature +intersection_of: UBERON:0001015 ! musculature +intersection_of: attaches_to UBERON:0008202 ! bone of hip region +relationship: attaches_to UBERON:0008202 ! bone of hip region +relationship: overlaps UBERON:0001464 ! hip + [Term] id: UBERON:0004476 name: musculature of shoulder @@ -262713,7 +371556,12 @@ subset: pheno_slim synonym: "muscle group of shoulder" EXACT [FMA:50220] synonym: "set of muscles of shoulder" EXACT [FMA:50220] xref: FMA:50220 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001015 ! musculature +intersection_of: UBERON:0001015 ! musculature +intersection_of: attaches_to UBERON:0003461 ! shoulder bone +relationship: attaches_to UBERON:0003461 ! shoulder bone +relationship: overlaps UBERON:0001467 ! shoulder [Term] id: UBERON:0004478 @@ -262811,6 +371659,37 @@ intersection_of: part_of UBERON:0002103 ! hindlimb relationship: part_of UBERON:0002103 ! hindlimb property_value: editor_note "currently defined by location rather than attachment" xsd:string +[Term] +id: UBERON:0004486 +name: musculature of perineum +namespace: uberon +def: "Any collection of muscles that is part of a perineum [Automatically generated definition]." [OBOL:automatic] +synonym: "musculi perinei" EXACT LATIN [FMA:71295, FMA:TA] +synonym: "perineal muscles" EXACT [FMA:71295] +synonym: "perineal muscles set" EXACT [FMA:71295] +synonym: "set of perineal muscles" EXACT [FMA:71295] +xref: EMAPA:36629 +xref: FMA:71295 +is_a: UBERON:0004479 ! musculature of trunk +relationship: part_of UBERON:0002356 ! perineum +property_value: editor_note "currently defined by location rather than attachment" xsd:string + +[Term] +id: UBERON:0004487 +name: musculature of forelimb zeugopod +is_a: UBERON:0004474 ! musculature of arm +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0002386 ! forelimb zeugopod +relationship: part_of UBERON:0002386 ! forelimb zeugopod + +[Term] +id: UBERON:0004488 +name: musculature of pes +is_a: UBERON:0004482 ! musculature of lower limb +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes + [Term] id: UBERON:0004489 name: musculature of manus @@ -262823,6 +371702,8 @@ synonym: "musculature of hand" EXACT [FMA:42368] synonym: "set of muscles of hand" EXACT [FMA:42368] xref: FMA:42368 is_a: UBERON:0004481 ! musculature of upper limb +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0002398 ! manus property_value: editor_note "currently defined by location rather than attachment" xsd:string @@ -262899,6 +371780,76 @@ intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: part_of UBERON:0001103 ! diaphragm relationship: part_of UBERON:0001103 ! diaphragm +[Term] +id: UBERON:0004500 +name: skeletal muscle tissue of deltoid +is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0001476 ! deltoid +relationship: part_of UBERON:0001476 ! deltoid + +[Term] +id: UBERON:0004502 +name: skeletal muscle tissue of biceps brachii +is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0001507 ! biceps brachii +relationship: part_of UBERON:0001507 ! biceps brachii + +[Term] +id: UBERON:0004508 +name: skeletal muscle tissue of levator palpebrae superioris +is_a: UBERON:0003269 ! skeletal muscle tissue of eye +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0001604 ! levator palpebrae superioris +relationship: part_of UBERON:0001604 ! levator palpebrae superioris + +[Term] +id: UBERON:0004509 +name: skeletal muscle tissue of trapezius +is_a: UBERON:0001134 ! skeletal muscle tissue +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0002380 ! trapezius muscle +relationship: part_of UBERON:0002380 ! trapezius muscle + +[Term] +id: UBERON:0004515 +name: smooth muscle tissue of bronchiole +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas +synonym: "smooth muscle tissue of lobular bronchiole" EXACT [FMA:261081] +xref: FMA:261045 +xref: FMA:261081 +is_a: UBERON:0004242 ! bronchus smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002186 ! bronchiole +relationship: part_of UBERON:0002186 ! bronchiole +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004516 +name: smooth muscle tissue of terminal bronchiole +namespace: uberon +def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas +xref: FMA:261051 +is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002187 ! terminal bronchiole +relationship: part_of UBERON:0002187 ! terminal bronchiole +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004517 +name: smooth muscle tissue of respiratory bronchiole +is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002188 ! respiratory bronchiole +relationship: part_of UBERON:0002188 ! respiratory bronchiole + [Term] id: UBERON:0004518 name: muscle of vertebral column @@ -262906,7 +371857,29 @@ namespace: uberon def: "A muscle that is attached to a vertebra of the vertebral column." [https://orcid.org/0000-0002-6601-2165] synonym: "vertebral column muscle" EXACT [FMA:22594] xref: FMA:22594 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0002412 ! vertebra +relationship: attaches_to UBERON:0002412 ! vertebra + +[Term] +id: UBERON:0004519 +name: muscle of anal triangle +namespace: uberon +def: "Any muscle organ that is part of a anal part of perineum." [OBOL:automatic] +synonym: "anal triangle muscle" EXACT [FMA:77304] +xref: FMA:77304 +is_a: UBERON:0002379 {source="FMA"} ! perineal muscle +relationship: part_of UBERON:0006867 ! anal part of perineum + +[Term] +id: UBERON:0004520 +name: striated muscle tissue of prostate +is_a: UBERON:0001134 ! skeletal muscle tissue +is_a: UBERON:0008715 ! muscle tissue of prostate +intersection_of: UBERON:0002036 ! striated muscle tissue +intersection_of: part_of UBERON:0002367 ! prostate gland [Term] id: UBERON:0004521 @@ -262955,6 +371928,8 @@ xref: MA:0001492 xref: SCTID:245795005 xref: Wikipedia:Alveolar_process is_a: UBERON:0004103 ! alveolar ridge +intersection_of: UBERON:0004103 ! alveolar ridge +intersection_of: part_of UBERON:0002397 ! maxilla relationship: part_of UBERON:0002397 ! maxilla property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/71/Gray157.png xsd:anyURI property_value: UBPROP:0000008 "In humans, the tooth-bearing bones are the maxilla and the mandible. The mineral content of alveolar bone is mostly hydroxyapatite, which is also found in enamel as the main inorganic substance" xsd:string {source="WP"} @@ -262977,6 +371952,8 @@ xref: FMA:52832 xref: SCTID:245791001 xref: Wikipedia:Alveolar_part_of_mandible is_a: UBERON:0004103 ! alveolar ridge +intersection_of: UBERON:0004103 ! alveolar ridge +intersection_of: part_of UBERON:0001684 ! mandible relationship: part_of UBERON:0001684 ! mandible property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/9f/Mandibule.jpg xsd:anyURI @@ -263036,7 +372013,30 @@ synonym: "bony projections" RELATED PLURAL [ZFA:0001637] synonym: "projection of bone" EXACT [] xref: FMA:75433 xref: ZFA:0001637 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:4100000 ! skeletal element projection +intersection_of: UBERON:4100000 ! skeletal element projection +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: continuous_with UBERON:0004765 ! skeletal element + +[Term] +id: UBERON:0004533 +name: left testis +is_a: UBERON:0000473 ! testis +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0000473 ! testis +intersection_of: in_left_side_of UBERON:0000990 ! reproductive system +relationship: in_left_side_of UBERON:0000990 ! reproductive system + +[Term] +id: UBERON:0004534 +name: right testis +is_a: UBERON:0000473 ! testis +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0000473 ! testis +intersection_of: in_right_side_of UBERON:0000990 ! reproductive system +relationship: in_right_side_of UBERON:0000990 ! reproductive system [Term] id: UBERON:0004535 @@ -263095,6 +372095,7 @@ id: UBERON:0004536 name: lymph vasculature namespace: uberon def: "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep." [ZFA:0005105] +subset: human_reference_atlas subset: vertebrate_core synonym: "lymph vessels" RELATED PLURAL [ZFA:0005105] synonym: "lymphatic trunks and ducts" EXACT [FMA:63815] @@ -263106,9 +372107,14 @@ synonym: "trunci et ductus lymphatici" EXACT LATIN [FMA:63815, FMA:TA] xref: FMA:63815 xref: TAO:0005105 xref: ZFA:0005105 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: has_part UBERON:0002391 ! lymph +relationship: has_part UBERON:0002391 ! lymph relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system property_value: editor_note "consider merging with parent" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005105", ontology="TAO", source="ZFIN:curator"} [Term] @@ -263116,6 +372122,7 @@ id: UBERON:0004537 name: blood vasculature namespace: uberon def: "A vascular network consisting of blood vessels." [https://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas synonym: "blood system" RELATED [] synonym: "blood vascular network" EXACT [] synonym: "blood vessel system" RELATED [] @@ -263128,6 +372135,23 @@ is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: composed_primarily_of UBERON:0001981 ! blood vessel relationship: composed_primarily_of UBERON:0001981 ! blood vessel +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004538 +name: left kidney +is_a: UBERON:0002113 ! kidney +intersection_of: UBERON:0002113 ! kidney +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0004539 +name: right kidney +is_a: UBERON:0002113 ! kidney +intersection_of: UBERON:0002113 ! kidney +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism [Term] id: UBERON:0004544 @@ -263146,6 +372170,9 @@ is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000485 ! simple columnar epithelium +intersection_of: part_of UBERON:0001301 ! epididymis +relationship: contributes_to_morphology_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] @@ -263164,10 +372191,10 @@ xref: DMBA:17765 xref: EMAPA:35331 xref: FMA:61959 xref: HBA:9243 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=253 xref: MA:0002896 xref: MBA:579 xref: NCIT:C32550 +xref: neuronames:253 xref: NLXANAT:1010013 xref: SCTID:279300007 xref: UMLS:C0152345 {source="ncithesaurus:External_Capsule"} @@ -263265,9 +372292,35 @@ xref: NCIT:C33009 xref: SCTID:267809009 xref: UMLS:C0227192 {source="ncithesaurus:Lower_Esophageal_Sphincter"} is_a: UBERON:0011185 ! gastrointestinal sphincter +relationship: contributes_to_morphology_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach property_value: editor_note "TODO - split? check FMA:63048 ! circular muscle layer of abdominal part of esophagus" xsd:string +[Term] +id: UBERON:0004552 +name: digital artery +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003514 ! limb blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: part_of UBERON:0002544 ! digit +relationship: part_of UBERON:0002544 ! digit + +[Term] +id: UBERON:0004553 +name: forelimb digital artery +is_a: UBERON:0003522 ! manual digit blood vessel +is_a: UBERON:0004552 ! digital artery +intersection_of: UBERON:0004552 ! digital artery +intersection_of: part_of UBERON:0002102 ! forelimb + +[Term] +id: UBERON:0004554 +name: hindlimb digital artery +is_a: UBERON:0003516 ! hindlimb blood vessel +is_a: UBERON:0004552 ! digital artery +intersection_of: UBERON:0004552 ! digital artery +intersection_of: part_of UBERON:0002103 ! hindlimb + [Term] id: UBERON:0004571 name: systemic arterial system @@ -263526,6 +372579,7 @@ id: UBERON:0004639 name: renal afferent arteriole namespace: uberon def: "The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism." [ISBN:0-683-40008-8, MGI:csmith, MP:0011312] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "afferent arteriole" EXACT [MA:0002579] @@ -263547,12 +372601,14 @@ is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001229 ! renal corpuscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004640 name: renal efferent arteriole namespace: uberon def: "The blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule." [ISBN:0-683-40008-8, MGI:csmith, MP:0011313] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "arteriola glomerularis efferens capsulae renalis" RELATED LATIN [Wikipedia:Efferent_arteriole] @@ -263573,12 +372629,14 @@ is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003644 ! kidney arterial blood vessel relationship: part_of UBERON:0001229 ! renal corpuscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004641 name: spleen capsule namespace: uberon def: "The connective tissue that surrounds the spleen." [MGI:cwg, MP:0002227] +subset: human_reference_atlas subset: pheno_slim synonym: "capsula splenica" EXACT LATIN [FMA:15849, FMA:TA] synonym: "capsule of spleen" EXACT [FMA:15849] @@ -263596,13 +372654,44 @@ xref: SCTID:329635002 xref: UMLS:C0229681 {source="ncithesaurus:Splenic_Capsule"} is_a: UBERON:0003893 ! capsule is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: part_of UBERON:0002106 ! spleen +relationship: contributes_to_morphology_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004642 +name: third ventricle ependyma +is_a: UBERON:0005357 ! brain ependyma +intersection_of: UBERON:0004670 ! ependyma +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002286 ! third ventricle + +[Term] +id: UBERON:0004643 +name: lateral ventricle ependyma +is_a: UBERON:0005357 ! brain ependyma +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0004670 ! ependyma +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle +relationship: part_of UBERON:0002285 ! telencephalic ventricle + +[Term] +id: UBERON:0004644 +name: fourth ventricle ependyma +is_a: UBERON:0005357 ! brain ependyma +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0004670 ! ependyma +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002422 ! fourth ventricle [Term] id: UBERON:0004645 name: urinary bladder urothelium namespace: uberon def: "The epithelial lining of the luminal space of the urinary bladder." [MP:0000540] +subset: human_reference_atlas subset: pheno_slim synonym: "bladder transitional cell epithelium" EXACT [FMA:15936] synonym: "epithelium of bladder" RELATED [EMAPA:28601] @@ -263623,7 +372712,11 @@ is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000365 ! urothelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000365 ! urothelium +intersection_of: part_of UBERON:0001255 ! urinary bladder +relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001259 ! mucosa of urinary bladder +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "5-7 cell layers thick in contracted bladder, 2-3 cells thick in distended bladder; lines renal pelvis, ureters, bladder, most of urethra but not distal urethra" xsd:string [Term] @@ -263631,6 +372724,7 @@ id: UBERON:0004646 name: infraorbital artery namespace: uberon def: "The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted]." [Wikipedia:Infraorbital_artery] +subset: human_reference_atlas synonym: "a. infraorbitalis" RELATED LATIN [Wikipedia:Infraorbital_artery] synonym: "infra-orbital artery" EXACT [FMA:49767] xref: EMAPA:37090 {source="MA:th"} @@ -263643,12 +372737,14 @@ xref: Wikipedia:Infraorbital_artery is_a: UBERON:0001637 ! artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray511.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004647 name: liver lobule namespace: uberon def: "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." [ISBN:0-683-40008-8, MP:0008987] +subset: human_reference_atlas subset: pheno_slim synonym: "hepatic lobule" EXACT [FMA:14471] synonym: "lobules of liver" RELATED PLURAL [Wikipedia:Lobules_of_liver] @@ -263664,8 +372760,11 @@ xref: UMLS:C0227518 {source="ncithesaurus:Hepatic_Lobule"} xref: Wikipedia:Lobules_of_liver is_a: UBERON:0000064 {source="FMA"} ! organ part is_a: UBERON:0004119 ! endoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0001280 ! liver parenchyma +relationship: has_part CL:0000182 ! hepatocyte relationship: part_of UBERON:0001280 {source="FMA", source="MA"} ! liver parenchyma property_value: IAO:0000232 "should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.[WP]" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004649 @@ -263698,6 +372797,14 @@ property_value: editor_note "TODO - check AAO:0000521-pterygoid and MA:0001471-p property_value: UBPROP:0000001 "Process that projects from posterior margin of commissure into subocular space.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010086", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000002 "relationship loss: part_of anterior quadratocranial commissure (AAO:0010061)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010086", ontology="AAO"} +[Term] +id: UBERON:0004650 +name: tongue keratinized epithelium +is_a: UBERON:0006919 ! tongue squamous epithelium +is_a: UBERON:0012329 ! keratinized stratified squamous epithelium +intersection_of: UBERON:0012329 ! keratinized stratified squamous epithelium +intersection_of: part_of UBERON:0001723 ! tongue + [Term] id: UBERON:0004651 name: scapula spine @@ -263740,6 +372847,8 @@ xref: SCTID:181927007 xref: Wikipedia:Body_of_humerus is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0000976 ! humerus relationship: part_of UBERON:0000976 ! humerus [Term] @@ -263862,6 +372971,8 @@ xref: MA:0002913 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle [Term] @@ -263891,6 +373002,9 @@ xref: VHOG:0000927 is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005983 ! heart layer is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000158 ! membranous layer +intersection_of: part_of UBERON:0002094 ! interventricular septum +relationship: contributes_to_morphology_of UBERON:0002094 ! interventricular septum relationship: develops_from UBERON:0000095 {source="Wikipedia"} ! cardiac neural crest relationship: part_of UBERON:0002094 ! interventricular septum property_value: UBPROP:0000001 "The membranous septum is the upper part of ventricular septum[GO:0003149]." xsd:string {source="GO:0003149"} @@ -263937,6 +373051,8 @@ xref: MA:0002945 is_a: UBERON:0000161 ! orifice is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000161 ! orifice +intersection_of: part_of UBERON:0002422 ! fourth ventricle relationship: part_of UBERON:0002422 ! fourth ventricle [Term] @@ -263952,14 +373068,18 @@ xref: BTO:0000401 xref: EMAPA:37865 {source="MA:th"} xref: FMA:242791 xref: GAID:608 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1856 xref: MESH:D004805 xref: NCIT:C13078 +xref: neuronames:1856 xref: SCTID:12766003 xref: UMLS:C0014472 {source="ncithesaurus:Ependyma"} xref: Wikipedia:Ependyma is_a: UBERON:0007601 ! ciliated epithelium is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: composed_primarily_of CL:0000065 ! ependymal cell +relationship: composed_primarily_of CL:0000065 ! ependymal cell +relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system relationship: develops_from UBERON:0004060 ! neural tube ventricular layer relationship: part_of UBERON:0005358 ! ventricle of nervous system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray667.png xsd:anyURI @@ -264006,14 +373126,25 @@ xref: EMAPA:37747 {source="MA:th"} xref: FMA:68871 xref: FMA:77036 xref: HBA:9525 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1649 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1702 +xref: neuronames:1649 +xref: neuronames:1702 xref: SCTID:362427009 xref: UMLS:C1512274 {source="BIRNLEX:2669"} xref: Wikipedia:Gray_commissure is_a: UBERON:0016570 {source="FMA"} ! lamina of gray matter of spinal cord property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c0/Medulla_spinalis_-_Substantia_grisea_-_English.svg xsd:anyURI +[Term] +id: UBERON:0004679 +name: dentate gyrus molecular layer +is_a: UBERON:0002304 ! layer of dentate gyrus +intersection_of: UBERON:0002304 ! layer of dentate gyrus +intersection_of: bounding_layer_of UBERON:0001885 ! dentate gyrus of hippocampal formation +relationship: bounding_layer_of UBERON:0001885 ! dentate gyrus of hippocampal formation +relationship: has_part GO:0030425 ! dendrite +relationship: has_part UBERON:0006134 ! nerve fiber +relationship: immediately_deep_to UBERON:0002361 ! pia mater + [Term] id: UBERON:0004681 name: vestibular system @@ -264031,6 +373162,10 @@ xref: NLXANAT:090819 xref: SCTID:361533001 xref: Wikipedia:Vestibular_system is_a: UBERON:0001032 ! sensory system +intersection_of: UBERON:0001032 ! sensory system +intersection_of: capable_of GO:0050957 ! equilibrioception +relationship: capable_of GO:0050957 ! equilibrioception +relationship: capable_of_part_of GO:0060005 ! vestibular reflex relationship: part_of UBERON:0002105 ! vestibulo-auditory system property_value: UBPROP:0000001 "The vestibular system, which contributes to our balance and our sense of spatial orientation, is the sensory system that provides the dominant input about movement and equilibrioception. Together with the cochlea, a part of the auditory system, it constitutes the labyrinth of the inner ear, situated in the vestibulum in the inner ear. As our movements consist of rotations and translations, the vestibular system comprises two components: the semicircular canal system, which indicate rotational movements; and the otoliths, which indicate linear accelerations. The vestibular system sends signals primarily to the neural structures that control our eye movements, and to the muscles that keep us upright. The projections to the former provide the anatomical basis of the vestibulo-ocular reflex, which is required for clear vision; and the projections to the muscles that control our posture are necessary to keep us upright[Wikipedia:Vestibular_system]." xsd:string {source="Wikipedia:Vestibular_system"} property_value: UBPROP:0000012 "FMA and NIF have no part information for this class. This is a GAT in FMA" xsd:string {external_ontology="FMA"} @@ -264054,10 +373189,10 @@ synonym: "set of raphe nuclei" RELATED [FMA:84017] xref: BAMS:RA xref: EMAPA:35721 xref: FMA:84017 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2495 xref: MA:0003147 -xref: MESH:A08.186.211.132.659.632 +xref: MESH:D011903 xref: NCIT:C97335 +xref: neuronames:2495 xref: NLXANAT:20090205 xref: TAO:0001429 xref: UMLS:C0034671 {source="ncithesaurus:Raphe_Nuclei"} @@ -264074,6 +373209,7 @@ name: costo-cervical trunk namespace: uberon def: "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." [http://en.wikipedia.org/wiki/Costocervical_trunk] def: "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." [Wikipedia:Costocervical_trunk] +subset: human_reference_atlas synonym: "costocervical trunk" EXACT [FMA:10636] synonym: "truncus costocervicalis" RELATED LATIN [Wikipedia:Costocervical_trunk] synonym: "truncus costocervicalis" RELATED LATIN [http://en.wikipedia.org/wiki/Costocervical_trunk] @@ -264086,7 +373222,28 @@ xref: MA:0001939 xref: SCTID:244225009 xref: Wikipedia:Costocervical_trunk is_a: UBERON:0001637 ! artery +relationship: connected_to UBERON:0001533 ! subclavian artery property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004691 +name: bulbourethral gland secretion +is_a: UBERON:0006314 ! bodily fluid +is_a: UBERON:0006530 ! seminal fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0002366 ! bulbo-urethral gland +relationship: has_quality PATO:0000998 ! viscous +relationship: produced_by UBERON:0002366 ! bulbo-urethral gland + +[Term] +id: UBERON:0004692 +name: external naris epithelium +is_a: UBERON:0019306 ! nose epithelium +is_a: UBERON:0035036 ! naris epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0005928 ! external naris +relationship: part_of UBERON:0005928 ! external naris [Term] id: UBERON:0004693 @@ -264229,9 +373386,9 @@ xref: EHDAA2:0000692 xref: EMAPA:35295 xref: FMA:62007 xref: HBA:4393 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1455 xref: MA:0000180 xref: ncithesaurus:Dorsal_Thalamus +xref: neuronames:1455 xref: PBA:128013018 xref: TAO:0000653 xref: ZFA:0000653 @@ -264274,7 +373431,7 @@ namespace: uberon def: "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." [ISBN:0-683-40008-8, MP:0010568] subset: pheno_slim subset: vertebrate_core -synonym: "primitive right ventricle endocardium" EXACT [EHDAA2:0000197, JB:def] +synonym: "primitive right ventricle endocardium" EXACT [EHDAA2:0000197] xref: EHDAA2:0000197 xref: EHDAA:438 xref: EHDAA:768 @@ -264291,6 +373448,15 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/c/c9/G property_value: editor_note "TODO - check relationship to bulbus arteriosus" xsd:string property_value: UBPROP:0000001 "A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000173", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0004707 +name: pharyngula stage +is_a: BFO:0000003 ! occurrent +is_a: UBERON:0000105 ! life cycle stage +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: part_of UBERON:0000111 ! organogenesis stage +relationship: preceded_by UBERON:0000110 ! neurula stage + [Term] id: UBERON:0004708 name: paired limb/fin @@ -264306,7 +373472,7 @@ synonym: "paired appendage" NARROW [VSAO:0000067] synonym: "pectoral or pelvic appendage" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "pelvic/pectoral appendage" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0000067 -is_a: BFO:0000040 ! material entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000026 {source="VSAO"} ! appendage intersection_of: UBERON:0000026 ! appendage intersection_of: part_of UBERON:0010707 ! appendage girdle complex @@ -264316,6 +373482,7 @@ relationship: has_part UBERON:0000014 ! zone of skin relationship: has_part UBERON:0001015 ! musculature relationship: has_part UBERON:0002049 ! vasculature relationship: has_skeleton UBERON:0011582 ! paired limb/fin skeleton +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0010707 {source="VSAO"} ! appendage girdle complex property_value: IAO:0000232 "this class is the union of the classes limb, pectoral fin and pelvic fin." xsd:string @@ -264413,10 +373580,10 @@ xref: BIRNLEX:1315 xref: BTO:0003448 xref: DHBA:12098 xref: FMA:61844 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=256 {source="BIRNLEX:1315"} xref: MA:0002979 xref: MESH:D012688 xref: NCIT:C33536 +xref: neuronames:256 {source="BIRNLEX:1315"} xref: SCTID:362313003 xref: UMLS:C0036700 {source="ncithesaurus:Septum_Pellucidum"} xref: UMLS:C0036700 {source="BIRNLEX:1315"} @@ -264428,6 +373595,15 @@ relationship: part_of UBERON:0000446 ! septum of telencephalon relationship: part_of UBERON:0002285 ! telencephalic ventricle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png xsd:anyURI +[Term] +id: UBERON:0004715 +name: annulus fibrosus disci intervertebralis +is_a: UBERON:0006444 ! annulus fibrosus +intersection_of: UBERON:0006444 ! annulus fibrosus +intersection_of: part_of UBERON:0001066 ! intervertebral disk +disjoint_from: UBERON:0006008 ! fibrous ring of heart +relationship: part_of UBERON:0001066 ! intervertebral disk + [Term] id: UBERON:0004716 name: conceptus @@ -264445,7 +373621,6 @@ xref: http://linkedlifedata.com/resource/umls/id/C1516779 xref: NCIT:C34131 xref: UMLS:C1516779 {source="ncithesaurus:Conceptus"} xref: Wikipedia:Conceptus -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000061 ! anatomical structure relationship: develops_from CL:0000365 ! animal zygote @@ -264460,6 +373635,7 @@ id: UBERON:0004719 name: kidney arcuate vein namespace: uberon def: "Any of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins." [ISBN:0-683-40008-8, MP:0011325] +subset: human_reference_atlas subset: pheno_slim synonym: "arciform vein of kidney" EXACT [MP:0011325] synonym: "arcuate vein" BROAD [MA:0002593] @@ -264474,7 +373650,8 @@ xref: MA:0002593 xref: Wikipedia:Arcuate_vein is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel -property_value: depicted:by Kidney:PioM.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000202 FMA:71632 [Term] @@ -264482,6 +373659,7 @@ id: UBERON:0004720 name: cerebellar vermis namespace: uberon def: "A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally)." [BIRNLEX:1106] +subset: human_reference_atlas subset: pheno_slim synonym: "cerebellum vermis" EXACT [FMA:76928] synonym: "vermal parts of the cerebellum" EXACT [BIRNLEX:1175] @@ -264502,18 +373680,24 @@ xref: EMAPA:35214 xref: EV:0100298 xref: FMA:76928 xref: HBA:4698 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2463 xref: MA:0000202 xref: MBA:645 +xref: MESH:D065814 xref: NCIT:C33866 +xref: neuronames:2463 xref: SCTID:279105006 xref: UMLS:C0228482 {source="ncithesaurus:Vermis"} xref: UMLS:C0228482 {source="BIRNLEX:1106"} xref: Wikipedia:Cerebellar_vermis is_a: UBERON:0002749 ! regional part of cerebellar cortex +relationship: BSPO:0005001 UBERON:0002037 ! cerebellum +relationship: capable_of_part_of GO:0040011 ! locomotion +relationship: capable_of_part_of NBO:0000355 ! posture +relationship: contributes_to_morphology_of UBERON:0002129 ! cerebellar cortex relationship: develops_from UBERON:0004008 ! cerebellar plate property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png xsd:anyURI property_value: RO:0002171 UBERON:0002245 +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "In bony fish, or teleosts, it has been proposed that the cerebellar auricles, which receive a large amount of input from the vestibulolateral line system, constitute the vestibulocerebellum and are homologues of the flocculonodular lobe of higher vertebrates along with the corpus cerebelli, which receives spinocerebellar and tectocerebellar fibers. The labyrinth and the lateral line organs of lampreys have structural and functional similarity. An important difference between the two structures is that the arrangement of the lateral line organs are such that they are sensitive to relative motion of the fluid surrounding the animal, whereas the labyrinths, having very similar sensing mechanisms, are sensitive to endolymph, providing information concerning the animal's own equilibrium of the body and orientation in space" xsd:string {source="WP"} property_value: UBPROP:0000012 "we follow MBA and NIFSTD in making this part of the cerebellar cortex, but FMA may handle this differently" xsd:string {external_ontology="NIF"} @@ -264545,6 +373729,7 @@ id: UBERON:0004723 name: interlobular artery namespace: uberon def: "The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule." [MP:0011316, Wikipedia:Interlobular_arteries] +subset: human_reference_atlas subset: pheno_slim synonym: "arteriae corticales radiatae" RELATED LATIN [Wikipedia:Interlobular_arteries] synonym: "arteriae interlobulares renis" RELATED LATIN [Wikipedia:Interlobular_arteries] @@ -264562,12 +373747,14 @@ xref: UMLS:C1512856 {source="ncithesaurus:Interlobular_Artery"} xref: Wikipedia:Interlobular_arteries is_a: UBERON:0003644 ! kidney arterial blood vessel property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004725 name: piriform cortex namespace: uberon def: "The subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions." [MP:0010009, PMID:17714095] +subset: human_reference_atlas subset: pheno_slim synonym: "area prepiriformis" RELATED LATIN [NeuroNames:165] synonym: "cortex piriformis" EXACT LATIN [Wikipedia:Piriform_cortex] @@ -264590,8 +373777,9 @@ xref: DHBA:10311 xref: EMAPA:32767 xref: EV:0100178 xref: HBA:10142 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=165 {source="BIRNLEX:1097"} xref: MA:0000978 +xref: MESH:D066195 +xref: neuronames:165 {source="BIRNLEX:1097"} xref: SCTID:369098004 xref: UMLS:C0228280 {source="BIRNLEX:1097"} xref: Wikipedia:Piriform_cortex @@ -264599,6 +373787,7 @@ is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002894 ! olfactory cortex property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "Piriform cortical regions are present in the brains of amphibians, reptiles and mammals. The piriform cortex is among three areas that emerge in the telencephalon of amphibians, situated caudally to a dorsal area, which is caudal to a hippocampal area. Farther along the phylogenic timeline, the telencephalic bulb of reptiles as viewed in a cross section of the transverse plane extends with the archipallial hippocampus folding toward the midline and down as the dorsal area begins to form a recognizable cortex. As mammalian cerebrums developed, volume of the dorsal cortex increased in slightly greater proportion, as compared proportionally with increased overall brain volume, until it enveloped the hippocampal regions. Recognized as neopallium or neocortex, enlarged dorsal areas envelop the paleopallial piriform cortex in humans and Old World monkeys. Among taxonomic groupings of mammals, the piriform cortex and the olfactory bulb become proportionally smaller in the brains of phylogenically younger species. The piriform cortex occupies a greater proportion of the overall brain and of the telencephalic brains of insectivores than in primates. The piriform cortex continues to occupy a consistent albeit small and declining proportion of the increasingly large telencephalon in the most recent primate species while the volume of the olfactory bulb becomes less in proportion" xsd:string {source="WP"} [Term] @@ -264606,6 +373795,7 @@ id: UBERON:0004726 name: vasa recta namespace: uberon def: "In the blood supply of the kidney, the vasa recta renis (or straight arteries of kidney, or straight arterioles of kidney) form a series of straight capillaries in the medulla. They lie parallel to the loop of Henle. These vessels branch off the efferent arterioles of juxtamedullary nephrons (those nephrons closest to the medulla), enter the medulla, and surround the loop of Henle." [Wikipedia:Vasa_recta] +subset: human_reference_atlas subset: pheno_slim synonym: "arteria recta" RELATED [Wikipedia:Vasa_recta] synonym: "arteriae rectae" RELATED [Wikipedia:Vasa_recta] @@ -264625,8 +373815,9 @@ xref: galen:ArteriaeRectae xref: MA:0002595 xref: Wikipedia:Vasa_recta is_a: UBERON:0001140 ! renal vein -property_value: depicted:by Kidney:nephron.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png xsd:anyURI property_value: editor_note "TODO - is this a vein or set of veins? in MA it is a venous blood vessel" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004727 @@ -264649,17 +373840,25 @@ xref: EHDAA2:0002195 xref: EMAPA:17802 xref: FMA:53431 xref: GAID:723 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1406 xref: MA:0001110 xref: MBA:948 xref: MESH:D003056 xref: NCIT:C12697 +xref: neuronames:1406 xref: OpenCyc:Mx4rwIhQfZwpEbGdrcN5Y29ycA xref: SCTID:280286001 xref: UMLS:C0009201 {source="ncithesaurus:Cochlear_Nerve"} xref: VHOG:0001182 xref: Wikipedia:Cochlear_nerve +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: branching_part_of UBERON:0001648 ! vestibulocochlear nerve +intersection_of: extends_fibers_into UBERON:0001720 ! cochlear nucleus +intersection_of: innervates UBERON:0001844 ! cochlea +relationship: branching_part_of UBERON:0001648 ! vestibulocochlear nerve +relationship: extends_fibers_into UBERON:0001720 ! cochlear nucleus +relationship: innervates UBERON:0001844 ! cochlea [Term] id: UBERON:0004731 @@ -264683,6 +373882,7 @@ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: part_of UBERON:0001049 ! neural tube +relationship: dc-contributor https://orcid.org/0000-0001-9114-8737 relationship: part_of UBERON:0001049 ! neural tube property_value: editor_note "We take the definition of neuromere from Puelles et al, although the existence of mesomeres and prosomeres may not be widely accepted" xsd:string property_value: UBPROP:0000001 "A metameric segment of the central nervous system.[ZFA]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001328", ontology="TAO", source="ZFIN:curator"} @@ -264746,6 +373946,7 @@ xref: http://en.wikipedia.org/wiki/Gastrula xref: http://linkedlifedata.com/resource/umls/id/C0017199 xref: http://linkedlifedata.com/resource/umls/id/C1284022 xref: MESH:A16.254.412 +xref: MESH:D005775 xref: MIAA:0000179 xref: NCIT:C34057 xref: NCIT:C34058 @@ -264762,6 +373963,34 @@ relationship: develops_from UBERON:0000307 ! blastula relationship: existence_starts_and_ends_during UBERON:0000109 ! gastrula stage property_value: UBPROP:0000012 "We explicitly merge the NCITA terms here" xsd:string {external_ontology="NCIT"} +[Term] +id: UBERON:0004736 +name: metanephric glomerulus +is_a: UBERON:0000074 ! renal glomerulus +intersection_of: UBERON:0000074 ! renal glomerulus +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0004737 +name: metanephric collecting duct +is_a: UBERON:0001232 ! collecting duct of renal tubule +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: develops_from UBERON:0003220 ! metanephric mesenchyme +relationship: develops_from UBERON:0014706 ! primitive renal collecting duct system +relationship: part_of UBERON:0005110 ! metanephric nephron + +[Term] +id: UBERON:0004739 +name: pronephric glomerulus +is_a: UBERON:0000074 ! renal glomerulus +intersection_of: UBERON:0000074 ! renal glomerulus +intersection_of: part_of UBERON:0002120 ! pronephros +relationship: develops_from UBERON:0007128 ! glomeral mesenchyme +relationship: part_of UBERON:0002120 ! pronephros + [Term] id: UBERON:0004742 name: dentary @@ -264832,6 +374061,7 @@ synonym: "germinal disc" EXACT [Wikipedia:Germinal_disc] xref: AAO:0000043 xref: BTO:0000494 xref: BTO:0001504 +xref: MESH:D054239 xref: NCIT:C34150 xref: TAO:0001175 xref: Wikipedia:Germinal_disc @@ -264847,7 +374077,7 @@ synonym: "germinal membrane" RELATED [BTO:0000126] synonym: "membrana germinativa" RELATED [BTO:0000126] xref: AAO:0000042 xref: BTO:0000126 -xref: MESH:A16.254.085.067 +xref: MESH:D001756 xref: TAO:0001176 xref: Wikipedia:Blastoderm xref: ZFA:0001176 @@ -264914,14 +374144,72 @@ intersection_of: has_part UBERON:0004755 ! skeletal tissue relationship: develops_from UBERON:0002067 ! dermis relationship: has_part UBERON:0004755 ! skeletal tissue +[Term] +id: UBERON:0004757 +name: rectal salt gland +namespace: uberon +def: "An evagination of the terminal portion of the intestine that is capable of secreting high concentrations of excess sodium chloride." [http://www.briancoad.com/dictionary/complete%20dictionary.htm, UBERON:cjm] +subset: organ_slim +synonym: "digitiform gland" BROAD [http://www.briancoad.com/dictionary/complete%20dictionary.htm] +synonym: "glandula rectalis" BROAD LATIN [http://www.briancoad.com/dictionary/complete%20dictionary.htm] +synonym: "rectal gland" BROAD [] +xref: BTO:0001157 +xref: SCTID:80455007 +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0004758 ! salt gland +intersection_of: UBERON:0002530 ! gland +intersection_of: capable_of GO:0055078 ! sodium ion homeostasis +intersection_of: part_of UBERON:0001052 ! rectum +relationship: confers_advantage_in ENVO:01000048 +relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata +relationship: part_of UBERON:0001052 ! rectum +property_value: RO:0002161 NCBITaxon:32523 +property_value: RO:0002175 NCBITaxon:118072 +property_value: RO:0002175 NCBITaxon:119203 +property_value: UBPROP:0000009 "shark liver produces copious amounts of urea, making the shark hyperosmotic to seawater, & thus a shark acts like a fresh water fish, constantly gaining water. Excess salts are concentrated by the rectal gland and secreted" xsd:string + +[Term] +id: UBERON:0004758 +name: salt gland +namespace: uberon +def: "An organ for excreting excess salts. It is found in elasmobranchs, seabirds, and some reptiles.[WP]." [Wikipedia:Salt_gland] +subset: functional_classification +subset: organ_slim +xref: BTO:0001204 +xref: GAID:1235 +xref: MESH:D012491 +xref: Wikipedia:Salt_gland +is_a: UBERON:0002530 ! gland +intersection_of: UBERON:0002530 ! gland +intersection_of: capable_of GO:0055078 ! sodium ion homeostasis +relationship: capable_of GO:0055078 ! sodium ion homeostasis +relationship: confers_advantage_in ENVO:00000447 +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +property_value: RO:0002161 NCBITaxon:40674 +property_value: UBPROP:0000008 "In sharks, salt glands are found in the rectum, but in birds and reptiles, they are found in or on the skull, in the area of the eyes, nostrils or mouth. In crocodiles, the salt is excreted through the tongue. Such glands work by active transport via sodium-potassium pump that moves salt from the blood into the gland, where it can be excreted as a concentrated solution. Salt glands function to keep salt balance, and allow marine vertebrates to drink seawater" xsd:string + +[Term] +id: UBERON:0004759 +name: cranial salt gland +namespace: uberon +def: "A salt gland located in the cranium or head region." [OBOL:automatic] +subset: organ_slim +is_a: UBERON:0004758 ! salt gland +intersection_of: UBERON:0004758 ! salt gland +intersection_of: part_of UBERON:0000033 ! head +relationship: part_of UBERON:0000033 ! head + [Term] id: UBERON:0004760 name: gland of anal canal namespace: uberon +def: "A gland that is part of an anal canal [Automatically generated definition]." [OBOL:automatic, Wikipedia:Anal_gland] def: "A gland that is part of an anal canal [Automatically generated definition]." [http://en.wikipedia.org/wiki/Anal_gland, OBOL:automatic] +subset: human_reference_atlas subset: organ_slim synonym: "anal gland" RELATED [] synonym: "anal sac" RELATED SENSU [http://en.wikipedia.org/wiki/Anal_gland] +synonym: "anal sac" RELATED SENSU [Wikipedia:Anal_gland] synonym: "gland of anal canal" EXACT [OBOL:automatic] synonym: "gland of anus" RELATED [] synonym: "rectal gland" RELATED [] @@ -264934,12 +374222,15 @@ xref: FMA:15724 xref: http://linkedlifedata.com/resource/umls/id/C0162322 xref: http://www.snomedbrowser.com/Codes/Details/245448005 xref: NCIT:C32068 +xref: SCTID:245448005 xref: UMLS:C0162322 {source="ncithesaurus:Anal_Gland"} +xref: Wikipedia:Anal_gland is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004761 @@ -264970,7 +374261,7 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system relationship: develops_from UBERON:0009617 {source="PMC1571569"} ! head paraxial mesoderm relationship: has_part UBERON:0002418 ! cartilage tissue -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: UBPROP:0000012 "in contrast to chondrocranium, this structure is entirely cartiliginous. In Chondricthyes this is the same as the neurocranium. FMA:76621 is an undefined fetal structure, so we assume the correct placement is here. Note that this is distinct from MA:0000317 which is the uberon:neurocranium (the part of the cranium that encloses the brain)" xsd:string {external_ontology="FMA"} [Term] @@ -265070,7 +374361,6 @@ xref: http://www.snomedbrowser.com/Codes/Details/361827000 xref: MA:0003007 xref: SCTID:361827000 xref: VSAO:0000181 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: has_member UBERON:0000982 ! skeletal joint @@ -265105,6 +374395,10 @@ xref: Wikipedia:Posterior_nasal_apertures xref: XAO:0000277 is_a: UBERON:0010425 ! internal naris is_a: UBERON:0036253 ! orifice of skull +intersection_of: UBERON:0010425 ! internal naris +intersection_of: connects UBERON:0001707 ! nasal cavity +intersection_of: connects UBERON:0001728 ! nasopharynx +relationship: connects UBERON:0001728 ! nasopharynx relationship: part_of UBERON:0003128 ! cranium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/87/Gray855.png xsd:anyURI property_value: UBPROP:0000001 "One of the paired openings from the nasal cavities into the pharynx. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-6, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000545", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -265132,9 +374426,26 @@ xref: UMLS:C0459586 {source="ncithesaurus:Tarsal_Plate"} xref: Wikipedia:Tarsus_(eyelids) is_a: UBERON:0000094 {source="FMA"} ! membrane organ is_a: UBERON:0010313 ! neural crest-derived structure +relationship: has_part CHEBI:18085 ! glycosaminoglycan relationship: part_of UBERON:0003581 {source="cjm"} ! eyelid connective tissue property_value: UBPROP:0000008 "In most taxa (birds, mammals, lizards), the tarsal plate is described as a dense, fibrous connective tissue, possibly including cartilage, present within one or both of the upper and lower eyelids (Gau- thier et al., 1988; Rieppel, 2000). In humans, the tarsal plate of the upper eyelid is composed of collagens types I, III, and V, as well as glycosaminogly- cans (chondroitin sulphate 4 and 6), aggrecan, and cartilage oligomeric matrix proteins but lacks collagen type II as well as chondrocytes (Milz et al., 2005). Thus, for humans, the upper tarsal plate represents neither a truly fibrous nor a truly cartilagi- nous element but instead one that is composed of a unique transitional tissue (Milz et al., 2005). In many birds, lizards, and Sphenodon (the tuatara), the upper eyelid has lim- ited mobility and a putative tarsal plate is instead found within the lower eyelid (Underwood, 1970; Gau- thier et al., 1988)." xsd:string {source="PMID:16496288"} +[Term] +id: UBERON:0004773 +name: superior eyelid tarsus +is_a: UBERON:0004772 ! eyelid tarsus +intersection_of: UBERON:0004772 ! eyelid tarsus +intersection_of: part_of UBERON:0001712 ! upper eyelid +relationship: part_of UBERON:0001712 ! upper eyelid + +[Term] +id: UBERON:0004774 +name: inferior eyelid tarsus +is_a: UBERON:0004772 ! eyelid tarsus +intersection_of: UBERON:0004772 ! eyelid tarsus +intersection_of: part_of UBERON:0001713 ! lower eyelid +relationship: part_of UBERON:0001713 ! lower eyelid + [Term] id: UBERON:0004775 name: outer renal medulla vasa recta @@ -265248,6 +374559,30 @@ intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal sy relationship: part_of UBERON:0004786 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! gastrointestinal system mucosa relationship: part_of UBERON:0004786 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! gastrointestinal system mucosa +[Term] +id: UBERON:0004781 +name: gall bladder lamina propria +namespace: uberon +def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +synonym: "biliary lamina propria" RELATED [MA:0001633] +synonym: "gall bladder lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "gallbladder lamina propria" EXACT [OBOL:automatic] +synonym: "gallbladder lamina propria mucosa" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of gall bladder" EXACT [OBOL:automatic] +synonym: "lamina propria mucosa of gallbladder" EXACT [OBOL:automatic] +synonym: "lamina propria of gall bladder" EXACT [OBOL:automatic] +synonym: "lamina propria of gallbladder" EXACT [OBOL:automatic] +xref: EMAPA:35371 +xref: FMA:278594 +xref: MA:0001633 +xref: NCIT:C49228 +xref: UMLS:C1708175 {source="ncithesaurus:Gallbladder_Lamina_Propria"} +is_a: UBERON:0000030 ! lamina propria +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0005033 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! mucosa of gallbladder + [Term] id: UBERON:0004782 name: gastrointestinal system serosa @@ -265267,6 +374602,32 @@ intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system +[Term] +id: UBERON:0004783 +name: gall bladder serosa +namespace: uberon +def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +synonym: "biliary serosa" RELATED [MA:0001634] +synonym: "gall bladder serous membrane" EXACT [OBOL:automatic] +synonym: "gallbladder serosa" EXACT [OBOL:automatic] +synonym: "gallbladder serous membrane" EXACT [OBOL:automatic] +synonym: "serosa of gall bladder" EXACT [OBOL:automatic] +synonym: "serosa of gallbladder" EXACT [OBOL:automatic] +synonym: "serous coat of gallbladder" EXACT [FMA:14659] +synonym: "serous membrane of gall bladder" EXACT [OBOL:automatic] +synonym: "serous membrane of gallbladder" EXACT [OBOL:automatic] +synonym: "tunica serosa (vesica biliaris)" EXACT [FMA:14659] +synonym: "tunica serosa vesicae biliaris" EXACT LATIN [FMA:14659, FMA:TA] +xref: EMAPA:35372 +xref: FMA:14659 +xref: MA:0001634 +xref: SCTID:362197006 +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder + [Term] id: UBERON:0004784 name: heart ventricle wall @@ -265348,7 +374709,6 @@ xref: EMAPA:36591 xref: http://www.snomedbrowser.com/Codes/Details/410433007 xref: MA:0001521 xref: SCTID:410433007 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa @@ -265375,6 +374735,9 @@ xref: NCIT:C49310 xref: UMLS:C1710585 {source="ncithesaurus:Urethra_Transitional_Cell_Epithelium"} is_a: UBERON:0000365 ! urothelium is_a: UBERON:0002325 ! epithelium of urethra +intersection_of: UBERON:0000365 ! urothelium +intersection_of: part_of UBERON:0000057 ! urethra +relationship: contributes_to_morphology_of UBERON:0000057 ! urethra [Term] id: UBERON:0004788 @@ -265405,8 +374768,26 @@ xref: NCIT:C54556 xref: UMLS:C1709899 {source="ncithesaurus:Renal_Pelvis_Urothelium"} is_a: UBERON:0000365 ! urothelium is_a: UBERON:0004819 ! kidney epithelium +intersection_of: UBERON:0000365 ! urothelium +intersection_of: part_of UBERON:0001224 ! renal pelvis +relationship: contributes_to_morphology_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis +[Term] +id: UBERON:0004789 +name: larynx mucous gland +namespace: uberon +def: "A mucous gland that is part of a larynx [Automatically generated definition]." [OBOL:automatic] +synonym: "mucous gland of larynx" EXACT [OBOL:automatic] +xref: EMAPA:37631 {source="MA:th"} +xref: MA:0001767 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: part_of UBERON:0001737 ! larynx +relationship: part_of UBERON:0001824 ! mucosa of larynx + [Term] id: UBERON:0004790 name: skin mucous gland @@ -265431,9 +374812,11 @@ id: UBERON:0004791 name: thymus trabecula namespace: uberon def: "The thymic connective tissue which extends into the parenchyma." [ISBN:0-397-51047-0, MGI:cwg, MP:0002370] +subset: human_reference_atlas subset: pheno_slim synonym: "thymic trabecula" EXACT [OBOL:automatic] synonym: "thymus gland trabecula" EXACT [OBOL:automatic] +synonym: "thymus trabeculae" EXACT PLURAL [] synonym: "trabecula of thymus" EXACT [OBOL:automatic] synonym: "trabecula of thymus gland" EXACT [OBOL:automatic] xref: MA:0002674 @@ -265441,7 +374824,47 @@ xref: NCIT:C33773 xref: UMLS:C1515431 {source="ncithesaurus:Thymic_Trabecula"} is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000440 ! trabecula +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0002370 ! thymus +relationship: contributes_to_morphology_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 {source="MA"} ! thymus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004792 +name: secretion of endocrine pancreas +namespace: uberon +def: "A secretion that is part of a endocrine pancreas [Automatically generated definition]." [OBOL:automatic] +synonym: "endocrine pancreas secretion" EXACT [OBOL:automatic] +synonym: "pancreatic endocrine secretion" EXACT [ncithesaurus:Pancreatic_Endocrine_Secretion] +synonym: "pars endocrina pancreatis secretion" EXACT [OBOL:automatic] +synonym: "secretion of pars endocrina pancreatis" EXACT [OBOL:automatic] +xref: MA:0002517 +xref: NCIT:C33255 +xref: UMLS:C1518866 {source="ncithesaurus:Pancreatic_Endocrine_Secretion"} +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: part_of UBERON:0000016 ! endocrine pancreas +relationship: part_of UBERON:0000016 ! endocrine pancreas + +[Term] +id: UBERON:0004793 +name: secretion of exocrine pancreas +namespace: uberon +def: "A secretion that is part of a exocrine pancreas [Automatically generated definition]." [OBOL:automatic] +synonym: "exocrine pancreas secretion" EXACT [OBOL:automatic] +synonym: "pancreatic exocrine secretion" EXACT [ncithesaurus:Pancreatic_Exocrine_Secretion] +synonym: "pars exocrina pancreatis secretion" EXACT [OBOL:automatic] +synonym: "secretion of pars exocrina pancreatis" EXACT [OBOL:automatic] +xref: MA:0002518 +xref: NCIT:C33256 +xref: UMLS:C1518867 {source="ncithesaurus:Pancreatic_Exocrine_Secretion"} +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: part_of UBERON:0000017 ! exocrine pancreas +relationship: part_of UBERON:0000017 ! exocrine pancreas [Term] id: UBERON:0004794 @@ -265475,8 +374898,18 @@ xref: MA:0002516 xref: NCIT:C13270 xref: UMLS:C0030296 {source="ncithesaurus:Pancreatic_Secretion"} is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas +[Term] +id: UBERON:0004796 +name: prostate gland secretion +is_a: UBERON:0006530 ! seminal fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0002367 ! prostate gland +relationship: produced_by UBERON:0002367 ! prostate gland + [Term] id: UBERON:0004797 name: blood vessel layer @@ -265490,6 +374923,7 @@ intersection_of: UBERON:0004923 ! organ component layer intersection_of: part_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0035965 ! wall of blood vessel property_value: depicted:by Blood:vessels.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg xsd:anyURI [Term] id: UBERON:0004801 @@ -265497,6 +374931,7 @@ name: cervix epithelium namespace: uberon def: "An epithelium that is part of a uterine cervix [Automatically generated definition]." [OBOL:automatic] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim synonym: "cervical canal epithelial tissue" EXACT [OBOL:automatic] synonym: "cervical canal epithelium" EXACT [OBOL:automatic] @@ -265511,7 +374946,11 @@ xref: MA:0001724 xref: NCIT:C49218 xref: UMLS:C1711358 {source="ncithesaurus:Cervix_Epithelium"} is_a: UBERON:0006955 ! uterine epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: contributes_to_morphology_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "The epithelium of the cervix is varied. The ectocervix (more distal, by the vagina) is composed of nonkeratinized stratified squamous epithelium. The endocervix (more proximal, within the uterus) is composed of simple columnar epithelium" xsd:string {source="Wikipedia:Cervix#Histology"} [Term] @@ -265539,11 +374978,21 @@ intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0000072 ! proximo-distal subdivision of respiratory tract +[Term] +id: UBERON:0004803 +name: penis epithelium +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000989 ! penis +relationship: part_of UBERON:0000989 ! penis + [Term] id: UBERON:0004804 name: oviduct epithelium namespace: uberon def: "An epithelium that is part of a oviduct [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "columnar epithelium of the fallopian tube" RELATED [BTO:0002402] synonym: "columnar epithelium of the oviduct" RELATED [BTO:0002402] synonym: "epithelial tissue of oviduct" EXACT [OBOL:automatic] @@ -265558,7 +375007,10 @@ xref: EMAPA:29043 xref: MA:0001718 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0003889 ! fallopian tube +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" xsd:string {external_ontology="FMA"} [Term] @@ -265581,8 +375033,19 @@ xref: UMLS:C1710049 {source="ncithesaurus:Seminal_Vesicle_Epithelium"} is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0012275 ! meso-epithelium is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000998 ! seminal vesicle relationship: part_of UBERON:0000998 ! seminal vesicle +[Term] +id: UBERON:0004806 +name: vas deferens epithelium +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001000 ! vas deferens +relationship: part_of UBERON:0001000 ! vas deferens + [Term] id: UBERON:0004807 name: respiratory system epithelium @@ -265638,6 +375101,8 @@ xref: CALOHA:TS-2067 xref: EMAPA:32816 xref: MA:0001587 is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0001044 ! saliva-secreting gland [Term] @@ -265653,6 +375118,11 @@ xref: MA:0001681 xref: NCIT:C49276 xref: UMLS:C1709902 {source="ncithesaurus:Renal_Tubule_Epithelium"} is_a: UBERON:0004211 ! nephron epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: adjacent_to UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0001231 ! nephron tubule +relationship: adjacent_to UBERON:0000464 ! anatomical space +relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001231 ! nephron tubule property_value: editor_note "See https://github.com/obophenotype/uberon/issues/1305" xsd:string @@ -265672,9 +375142,19 @@ xref: MA:0002731 xref: SCTID:253526009 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0006955 ! uterine epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium property_value: UBPROP:0000008 "In rodents and primates, the uterine epithelium (the endometrium) is eroded away so that maternal blood comes into direct contact with the trophoblast surface (called haemochorial)" xsd:string {source="PMID:19829370"} +[Term] +id: UBERON:0004812 +name: male prepuce epithelium +is_a: UBERON:0004803 ! penis epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001332 ! prepuce of penis +relationship: part_of UBERON:0001332 ! prepuce of penis + [Term] id: UBERON:0004813 name: seminiferous tubule epithelium @@ -265707,6 +375187,11 @@ xref: Wikipedia:Germinal_epithelium_(male) is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis +relationship: contributes_to_morphology_of UBERON:0001343 ! seminiferous tubule of testis +relationship: has_part CL:0000020 ! spermatogonium +relationship: has_part CL:0000216 ! Sertoli cell relationship: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] @@ -265720,6 +375205,8 @@ synonym: "upper respiratory tract epithelial tissue" EXACT [OBOL:automatic] xref: EMAPA:35894 xref: MA:0001912 is_a: UBERON:0004802 ! respiratory tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract [Term] @@ -265813,6 +375300,9 @@ xref: UMLS:C1711208 {source="ncithesaurus:Bile_Duct_Epithelium"} is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0034932 ! epithelium of biliary system is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002394 ! bile duct +relationship: has_part CL:1000488 ! cholangiocyte relationship: part_of UBERON:0002394 ! bile duct property_value: UBPROP:0000001 "The irregularly shaped proliferating bile ducts are lined by normal cuboidal epithelium." xsd:string {source="BTO:0000417"} @@ -265837,8 +375327,65 @@ xref: MA:0001771 xref: NCIT:C12867 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 {source="FMA"} ! simple squamous epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002299 ! alveolus of lung +relationship: contributes_to_morphology_of UBERON:0000115 ! lung epithelium +relationship: contributes_to_morphology_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0004894 {source="FMA"} ! alveolar wall +[Term] +id: UBERON:0004822 +name: extrahepatic bile duct epithelium +namespace: uberon +def: "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +synonym: "epithelial tissue of extrahepatic bile duct" EXACT [OBOL:automatic] +synonym: "epithelium of extrahepatic bile duct" EXACT [OBOL:automatic] +synonym: "extrahepatic bile duct epithelial tissue" EXACT [OBOL:automatic] +xref: EHDAA2:0000742 +xref: EHDAA:3051 +xref: MA:0002661 +xref: NCIT:C43618 +xref: UMLS:C1711347 {source="ncithesaurus:Extrahepatic_Bile_Duct_Epithelium"} +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003703 ! extrahepatic bile duct +relationship: part_of UBERON:0003703 ! extrahepatic bile duct + +[Term] +id: UBERON:0004823 +name: intrahepatic bile duct epithelium +namespace: uberon +def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +synonym: "epithelial tissue of intrahepatic bile duct" EXACT [OBOL:automatic] +synonym: "epithelium of intrahepatic bile duct" EXACT [OBOL:automatic] +synonym: "intrahepatic bile duct epithelial tissue" EXACT [OBOL:automatic] +xref: EHDAA2:0000743 +xref: EHDAA:3053 +xref: MA:0002662 +xref: NCIT:C43617 +xref: UMLS:C1708552 {source="ncithesaurus:Intrahepatic_Bile_Duct_Epithelium"} +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003704 ! intrahepatic bile duct +relationship: part_of UBERON:0003704 ! intrahepatic bile duct + +[Term] +id: UBERON:0004827 +name: thyroid gland medulla +is_a: UBERON:0000958 ! medulla of organ +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland + +[Term] +id: UBERON:0004829 +name: urethra skeletal muscle tissue +is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0000057 ! urethra +relationship: part_of UBERON:0003829 ! urethra muscle tissue + [Term] id: UBERON:0004830 name: respiratory system skeletal muscle @@ -265890,6 +375437,8 @@ synonym: "skeletal muscle tissue of anal triangle" EXACT [OBOL:automatic] xref: EMAPA:37393 {source="MA:th"} xref: MA:0001530 is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: part_of UBERON:0001353 ! anal region relationship: part_of UBERON:0001353 ! anal region [Term] @@ -265908,11 +375457,34 @@ intersection_of: part_of UBERON:0001833 ! lip relationship: part_of UBERON:0001833 ! lip property_value: editor_note "this class is derived from MA. Consider re-modeling this as being a muscle that acts on the lips. See: Wikipedia:Lip#Muscles_acting_on_the_lips" xsd:string +[Term] +id: UBERON:0004834 +name: hepatic duct smooth muscle +namespace: uberon +def: "Smooth muscle tissue in all or part of a hepatic duct." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:37598 {source="MA:th"} +xref: MA:0001640 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0005171 ! hepatic duct +relationship: part_of UBERON:0005171 ! hepatic duct + +[Term] +id: UBERON:0004835 +name: epididymis smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001301 ! epididymis +relationship: part_of UBERON:0001301 ! epididymis + [Term] id: UBERON:0004848 name: respiratory system arterial endothelium namespace: uberon def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "apparatus respiratorius arterial endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius artery endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius endothelium of artery" EXACT [OBOL:automatic] @@ -265932,12 +375504,14 @@ intersection_of: UBERON:0001917 ! endothelium of artery intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003469 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! respiratory system artery relationship: part_of UBERON:0003469 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! respiratory system artery +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004849 name: respiratory system venous endothelium namespace: uberon def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas synonym: "apparatus respiratorius endothelium of vein" EXACT [OBOL:automatic] synonym: "apparatus respiratorius vein endothelium" EXACT [OBOL:automatic] synonym: "apparatus respiratorius venous endothelium" EXACT [OBOL:automatic] @@ -265956,6 +375530,15 @@ is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001919 ! endothelium of vein intersection_of: part_of UBERON:0001004 ! respiratory system relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004850 +name: lymph node endothelium +is_a: UBERON:0001986 ! endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: part_of UBERON:0000029 ! lymph node [Term] id: UBERON:0004851 @@ -266026,6 +375609,8 @@ xref: EMAPA:37068 {source="MA:th"} xref: MA:0001900 is_a: UBERON:0002095 ! mesentery is_a: UBERON:0004782 ! gastrointestinal system serosa +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system [Term] id: UBERON:0004857 @@ -266068,11 +375653,28 @@ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0000970 ! eye relationship: part_of UBERON:0000970 ! eye +[Term] +id: UBERON:0004861 +name: right lung alveolus +is_a: UBERON:0002299 ! alveolus of lung +intersection_of: UBERON:0003215 ! alveolus +intersection_of: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0006526 ! right lung alveolar system + +[Term] +id: UBERON:0004862 +name: left lung alveolus +is_a: UBERON:0002299 ! alveolus of lung +intersection_of: UBERON:0003215 ! alveolus +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0006525 ! left lung alveolar system + [Term] id: UBERON:0004864 name: vasculature of retina namespace: uberon def: "A vasculature that is part of a retina [Automatically generated definition]." [OBOL:automatic] +subset: human_reference_atlas subset: pheno_slim synonym: "retina vasculature" EXACT [GO:0061298] synonym: "retina vasculature of camera-type eye" EXACT [GO:0061298] @@ -266091,6 +375693,24 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina property_value: RO:0002161 NCBITaxon:8782 {source="PMID:21622558", source="PMID:2772405", submitter="michaelerice"} +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004867 +name: orbital cavity +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0001697 ! orbit of skull +relationship: luminal_space_of UBERON:0001697 ! orbit of skull + +[Term] +id: UBERON:0004869 +name: parietal organ +is_a: UBERON:0003103 ! compound organ +is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: part_of UBERON:0015238 ! pineal complex [Term] id: UBERON:0004871 @@ -266171,6 +375791,7 @@ xref: VHOG:0000557 xref: Wikipedia:Somatopleure is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure +relationship: overlaps UBERON:0000924 ! ectoderm relationship: part_of UBERON:0003081 {source="EHDAA2"} ! lateral plate mesoderm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png xsd:anyURI property_value: UBPROP:0000011 "Gives rise to the paired appendages in jawed vertebrates. a persistent somatopleure through the redistribution and expansion of the lateral plate mesoderm is a synapomorphy for gnathostomes and a critical step in generating a novel developmental module with dramatic evolutionary potentia (Tulenko et al. 2012) http://burkelab.research.wesleyan.edu/current-projects/lamprey/" xsd:string @@ -266267,6 +375888,7 @@ id: UBERON:0004883 name: lung mesenchyme namespace: uberon def: "The mass of tissue made up of mesenchymal cells in the lung." [GO:0060484] +subset: human_reference_atlas subset: pheno_slim synonym: "lung-associated mesenchyme" EXACT [GO:0060484] synonym: "mesenchyme of lung" EXACT [OBOL:automatic] @@ -266278,6 +375900,23 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002048 ! lung relationship: develops_from UBERON:0003081 ! lateral plate mesoderm relationship: part_of UBERON:0002048 ! lung +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004884 +name: lobar bronchus mesenchyme +is_a: UBERON:0004883 ! lung mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus + +[Term] +id: UBERON:0004889 +name: lobar bronchus vasculature +is_a: UBERON:0000102 ! lung vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus [Term] id: UBERON:0004890 @@ -266313,6 +375952,9 @@ xref: UMLS:C1706784 {source="ncithesaurus:Alveolar_Septum"} xref: Wikipedia:Alveolar_septum is_a: UBERON:0003037 ! septum is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003037 ! septum +intersection_of: adjacent_to UBERON:0002299 ! alveolus of lung +relationship: adjacent_to UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0006524 ! alveolar system [Term] @@ -266335,9 +375977,29 @@ xref: SCTID:361965008 xref: UMLS:C0225695 {source="ncithesaurus:Alveolar_Wall"} is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002299 ! alveolus of lung +relationship: contributes_to_morphology_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung property_value: UBPROP:0000012 "part of wall in FMA" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0004895 +name: alveolar smooth muscle +is_a: UBERON:0004233 ! lower respiratory tract smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002299 ! alveolus of lung +relationship: part_of UBERON:0002299 ! alveolus of lung + +[Term] +id: UBERON:0004901 +name: right lung lobar bronchus mesenchyme +is_a: UBERON:0004884 ! lobar bronchus mesenchyme +is_a: UBERON:0009603 ! right lung associated mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002167 ! right lung +intersection_of: part_of UBERON:0002183 ! lobar bronchus + [Term] id: UBERON:0004902 name: urogenital sinus epithelium @@ -266488,8 +376150,9 @@ synonym: "testis epithelium" EXACT [OBOL:automatic] synonym: "testis sheath" NARROW SENSU [FBbt:00004955] xref: BTO:0001364 xref: EMAPA:17973 -xref: FBbt:00004955 is_a: UBERON:0004909 ! epithelium of gonad +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000473 ! testis relationship: part_of UBERON:0000473 ! testis property_value: editor_note "after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts" xsd:string @@ -266502,7 +376165,6 @@ synonym: "ovarian epithelium" EXACT [OBOL:automatic] synonym: "ovarian sheath" NARROW SENSU [FBbt:00004896] synonym: "ovary epithelium" EXACT [OBOL:automatic] xref: BTO:0003661 -xref: FBbt:00004896 is_a: UBERON:0004909 ! epithelium of gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000992 ! ovary @@ -266526,6 +376188,89 @@ relationship: develops_from UBERON:0004161 {source="EHDAA2-modified"} ! septum t relationship: part_of UBERON:0002423 {source="EHDAA2"} ! hepatobiliary system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png xsd:anyURI +[Term] +id: UBERON:0004913 +name: hepatopancreatic ampulla +namespace: uberon +def: "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." [Wikipedia:Ampulla_of_Vater] +subset: human_reference_atlas +subset: vertebrate_core +synonym: "ampulla biliaropancreatica" EXACT LATIN [FMA:15076, FMA:TA] +synonym: "ampulla hepatopancreatica" RELATED LATIN [Wikipedia:Ampulla_of_Vater] +synonym: "ampulla of bile duct" EXACT [FMA:15076] +synonym: "ampulla of Vater" EXACT [] +synonym: "ampulla Vaterii" RELATED LATIN [Wikipedia:Ampulla_of_Vater] +synonym: "biliaropancreatic ampulla" EXACT [] +synonym: "papilla duodeni major" RELATED [ZFA:0005167] +synonym: "papilla Vateri" EXACT [ZFA:0005167] +synonym: "Vater's ampulla" EXACT [] +xref: CALOHA:TS-2348 +xref: FMA:15076 +xref: GAID:283 +xref: galen:AmpullaOfVater +xref: MESH:D014670 +xref: NCIT:C13011 +xref: SCTID:362200007 +xref: TAO:0005167 +xref: UMLS:C0042425 {source="ncithesaurus:Ampulla_of_Vater"} +xref: Wikipedia:Ampulla_of_Vater +xref: ZFA:0005167 +is_a: UBERON:0002394 ! bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0001174 ! common bile duct +intersection_of: part_of UBERON:0004914 ! duodenal papilla +relationship: part_of UBERON:0001174 ! common bile duct +relationship: part_of UBERON:0004914 ! duodenal papilla +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000001 "Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005167", ontology="TAO", source="ZFIN:ZDB-PUB-070212-11", source="ZFIN:ZDB-PUB-080414-12"} + +[Term] +id: UBERON:0004914 +name: duodenal papilla +namespace: uberon +def: "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." [http://medical-dictionary.thefreedictionary.com/duodenal+papilla] +synonym: "papilla duodenalis" EXACT [] +synonym: "papilla duodeni" RELATED LATIN [Wikipedia:Major_duodenal_papilla] +synonym: "papilla of duodenum" EXACT [] +xref: EMAPA:18662 +xref: FMA:15953 +xref: MA:0003107 +xref: NCIT:C119578 +xref: SCTID:245389007 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0034944 ! zone of organ +relationship: part_of UBERON:0000320 ! duodenal mucosa +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png xsd:anyURI + +[Term] +id: UBERON:0004915 +name: sphincter of hepatopancreatic ampulla +namespace: uberon +def: "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." [Wikipedia:Sphincter_of_ampulla] +subset: human_reference_atlas +synonym: "hepatopancreatic ampullary sphincter" EXACT [FMA:15077] +synonym: "musculus sphincter ampullae" EXACT [FMA:15077] +synonym: "musculus sphincter ampullae hepatopancreatica" EXACT LATIN [FMA:15077, FMA:TA] +synonym: "Oddi's sphincter" EXACT [] +synonym: "sphincter of ampulla of vater" EXACT [FMA:15077] +synonym: "sphincter of Oddi" EXACT [] +xref: EMAPA:18663 +xref: FMA:15077 +xref: GAID:285 +xref: MESH:D009803 +xref: NCIT:C13065 +xref: SCTID:181271000 +xref: UMLS:C0028872 {source="ncithesaurus:Sphincter_of_Oddi"} +xref: Wikipedia:Sphincter_of_ampulla +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0004913 ! hepatopancreatic ampulla +relationship: part_of UBERON:0004913 ! hepatopancreatic ampulla +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0004916 name: anal sphincter @@ -266535,8 +376280,19 @@ synonym: "anal region sphincter" EXACT [] synonym: "sphincter analia" EXACT [] xref: EMAPA:36052 is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0001353 ! anal region +relationship: capable_of_part_of GO:0030421 ! defecation relationship: part_of UBERON:0001353 ! anal region +[Term] +id: UBERON:0004917 +name: urethral sphincter +is_a: UBERON:0003829 ! urethra muscle tissue +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0000057 ! urethra + [Term] id: UBERON:0004921 name: subdivision of digestive tract @@ -266581,9 +376337,9 @@ xref: BAMS:SEZ xref: BTO:0003090 xref: DHBA:10536 xref: EMAPA:32804 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1901 xref: MA:0000817 xref: MBA:98 +xref: neuronames:1901 xref: NLX:144262 xref: PBA:294021970 xref: Wikipedia:Subventricular_zone @@ -266630,6 +376386,67 @@ intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001042 ! chordate pharynx relationship: part_of UBERON:0001042 ! chordate pharynx +[Term] +id: UBERON:0004925 +name: submucosa of laryngopharynx +is_a: UBERON:0004924 ! submucosa of pharynx +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001051 ! hypopharynx + +[Term] +id: UBERON:0004926 +name: submucosa of cystic duct +namespace: uberon +def: "A submucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "cystic duct submucosa" EXACT [OBOL:automatic] +synonym: "cystic ductal submucosa" EXACT [FMA:18013] +xref: FMA:18013 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001152 ! cystic duct +relationship: part_of UBERON:0001152 ! cystic duct + +[Term] +id: UBERON:0004927 +name: submucosa of cecum +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001153 ! caecum +relationship: part_of UBERON:0001153 ! caecum + +[Term] +id: UBERON:0004928 +name: submucosa of appendix +is_a: UBERON:0001208 ! submucosa of large intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:0004929 +name: submucosa of ascending colon +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001156 ! ascending colon +relationship: part_of UBERON:0001156 ! ascending colon + +[Term] +id: UBERON:0004930 +name: submucosa of transverse colon +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001157 ! transverse colon +relationship: part_of UBERON:0001157 ! transverse colon + +[Term] +id: UBERON:0004931 +name: submucosa of descending colon +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001158 ! descending colon +relationship: part_of UBERON:0001158 ! descending colon + [Term] id: UBERON:0004932 name: submucosa of sigmoid colon @@ -266642,6 +376459,146 @@ intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001159 ! sigmoid colon relationship: part_of UBERON:0001159 ! sigmoid colon +[Term] +id: UBERON:0004933 +name: submucosa of fundus of stomach +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001160 ! fundus of stomach +relationship: part_of UBERON:0001160 ! fundus of stomach + +[Term] +id: UBERON:0004934 +name: submucosa of body of stomach +namespace: uberon +def: "A submucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +synonym: "body of stomach submucosa" EXACT [OBOL:automatic] +synonym: "corpus gastricum (ventriculare) submucosa" EXACT [OBOL:automatic] +synonym: "gastric body submucosa" EXACT [OBOL:automatic] +synonym: "stomach body submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] +synonym: "submucosa of gastric body" EXACT [OBOL:automatic] +synonym: "submucosa of stomach body" EXACT [OBOL:automatic] +xref: FMA:17059 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001161 ! body of stomach +relationship: part_of UBERON:0001161 ! body of stomach + +[Term] +id: UBERON:0004935 +name: submucosa of cardia of stomach +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001162 ! cardia of stomach +relationship: part_of UBERON:0001162 ! cardia of stomach + +[Term] +id: UBERON:0004936 +name: submucosa of pyloric antrum +namespace: uberon +def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +synonym: "antrum of stomach submucosa" EXACT [OBOL:automatic] +synonym: "pyloric antrum submucosa" EXACT [OBOL:automatic] +synonym: "stomach pyloric antrum submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of antrum of stomach" EXACT [OBOL:automatic] +synonym: "submucosa of stomach pyloric antrum" EXACT [OBOL:automatic] +xref: FMA:17060 +is_a: UBERON:0004937 ! submucosa of pylorus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001165 ! pyloric antrum +relationship: part_of UBERON:0001165 ! pyloric antrum + +[Term] +id: UBERON:0004937 +name: submucosa of pylorus +namespace: uberon +def: "A submucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] +synonym: "pyloric part of stomach submucosa" EXACT [OBOL:automatic] +synonym: "pyloric submucosa" EXACT [] +synonym: "pylorus submucosa" EXACT [OBOL:automatic] +synonym: "pylorus submucosa" EXACT [FMA:17462] +synonym: "stomach pyloric region submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of pyloric part of stomach" EXACT [OBOL:automatic] +synonym: "submucosa of stomach pyloric region" EXACT [OBOL:automatic] +xref: EMAPA:27201 +xref: FMA:17462 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001166 ! pylorus +relationship: part_of UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0004938 +name: submucosa of biliary tree +namespace: uberon +def: "A submucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +synonym: "biliary tract submucosa" EXACT [OBOL:automatic] +synonym: "biliary tree submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of biliary tract" EXACT [OBOL:automatic] +xref: FMA:18009 +is_a: UBERON:0000009 ! submucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001173 ! biliary tree +relationship: part_of UBERON:0001173 ! biliary tree + +[Term] +id: UBERON:0004939 +name: submucosa of common bile duct +namespace: uberon +def: "A submucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +synonym: "common bile duct submucosa" EXACT [OBOL:automatic] +synonym: "common bile ductal submucosa" EXACT [FMA:18011] +synonym: "ductus choledochus (biliaris) submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] +xref: FMA:18011 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001174 ! common bile duct +relationship: part_of UBERON:0001174 ! common bile duct + +[Term] +id: UBERON:0004940 +name: submucosa of common hepatic duct +namespace: uberon +def: "A submucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "common hepatic duct submucosa" EXACT [OBOL:automatic] +synonym: "common hepatic ductal submucosa" EXACT [FMA:18014] +synonym: "hepatic duct submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of hepatic duct" EXACT [OBOL:automatic] +xref: FMA:18014 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001175 ! common hepatic duct +relationship: part_of UBERON:0001175 ! common hepatic duct + +[Term] +id: UBERON:0004941 +name: submucosa of right hepatic duct +namespace: uberon +def: "A submucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "right hepatic duct submucosa" EXACT [OBOL:automatic] +synonym: "right hepatic ductal submucosa" EXACT [FMA:18015] +xref: FMA:18015 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001176 ! right hepatic duct +relationship: part_of UBERON:0001176 ! right hepatic duct + +[Term] +id: UBERON:0004942 +name: submucosa of left hepatic duct +namespace: uberon +def: "A submucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "left hepatic duct submucosa" EXACT [OBOL:automatic] +synonym: "left hepatic ductal submucosa" EXACT [FMA:18017] +xref: FMA:18017 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001177 ! left hepatic duct +relationship: part_of UBERON:0001177 ! left hepatic duct + [Term] id: UBERON:0004943 name: submucosa of urinary bladder @@ -266664,6 +376621,84 @@ intersection_of: UBERON:0000009 ! submucosa intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001256 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! wall of urinary bladder +[Term] +id: UBERON:0004944 +name: submucosa of trigone of urinary bladder +is_a: UBERON:0004943 ! submucosa of urinary bladder +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder +relationship: part_of UBERON:0001257 ! trigone of urinary bladder + +[Term] +id: UBERON:0004945 +name: submucosa of neck of urinary bladder +is_a: UBERON:0004943 ! submucosa of urinary bladder +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0001258 ! neck of urinary bladder +relationship: part_of UBERON:0001258 ! neck of urinary bladder + +[Term] +id: UBERON:0004946 +name: submucosa of ileum +is_a: UBERON:0001205 ! submucosa of small intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002116 ! ileum +relationship: part_of UBERON:0002116 ! ileum + +[Term] +id: UBERON:0004947 +name: submucosa of right main bronchus +is_a: UBERON:0004949 ! submucosa of main bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002177 ! right main bronchus +relationship: part_of UBERON:0002177 ! right main bronchus + +[Term] +id: UBERON:0004948 +name: submucosa of left main bronchus +is_a: UBERON:0004949 ! submucosa of main bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002178 ! left main bronchus +relationship: part_of UBERON:0002178 ! left main bronchus + +[Term] +id: UBERON:0004949 +name: submucosa of main bronchus +is_a: UBERON:0001957 ! submucosa of bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + +[Term] +id: UBERON:0004950 +name: submucosa of lobar bronchus +is_a: UBERON:0001957 ! submucosa of bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus + +[Term] +id: UBERON:0004951 +name: submucosa of segmental bronchus +is_a: UBERON:0001957 ! submucosa of bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002184 ! segmental bronchus +relationship: part_of UBERON:0002184 ! segmental bronchus + +[Term] +id: UBERON:0004952 +name: submucosa of bronchiole +namespace: uberon +def: "A submucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiole submucosa" EXACT [OBOL:automatic] +synonym: "lobular bronchiole submucosa" EXACT [OBOL:automatic] +synonym: "submucosa of lobular bronchiole" EXACT [OBOL:automatic] +xref: FMA:62775 +is_a: UBERON:0001957 ! submucosa of bronchus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0002186 ! bronchiole +relationship: part_of UBERON:0002186 ! bronchiole + [Term] id: UBERON:0004980 name: mucosa of ureter @@ -266690,6 +376725,108 @@ intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0000056 ! ureter relationship: part_of UBERON:0009916 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! wall of ureter +[Term] +id: UBERON:0004982 +name: mucosa of epiglottis +is_a: UBERON:0004987 ! mucosa of laryngopharynx +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000388 ! epiglottis +relationship: part_of UBERON:0000388 ! epiglottis + +[Term] +id: UBERON:0004983 +name: mucosa of vagina +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + +[Term] +id: UBERON:0004984 +name: mucosa of seminal vesicle +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000998 ! seminal vesicle +relationship: part_of UBERON:0000998 ! seminal vesicle + +[Term] +id: UBERON:0004985 +name: mucosa of ejaculatory duct +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000999 ! ejaculatory duct +relationship: part_of UBERON:0000999 ! ejaculatory duct + +[Term] +id: UBERON:0004986 +name: mucosa of deferent duct +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001000 ! vas deferens +relationship: part_of UBERON:0001000 ! vas deferens + +[Term] +id: UBERON:0004987 +name: mucosa of laryngopharynx +is_a: UBERON:0000355 ! pharyngeal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001051 ! hypopharynx + +[Term] +id: UBERON:0004988 +name: mucosa of cystic duct +namespace: uberon +def: "A mucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "cystic duct mucosa" EXACT [OBOL:automatic] +synonym: "cystic duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "cystic duct mucous membrane" EXACT [OBOL:automatic] +synonym: "cystic duct organ mucosa" EXACT [OBOL:automatic] +synonym: "cystic ductal mucosa" EXACT [FMA:14690] +synonym: "mucosa of organ of cystic duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of cystic duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of cystic duct" EXACT [OBOL:automatic] +xref: FMA:14690 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001152 ! cystic duct +relationship: part_of UBERON:0001152 ! cystic duct + +[Term] +id: UBERON:0004989 +name: mucosa of appendix +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:0004990 +name: mucosa of ascending colon +is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001156 ! ascending colon +relationship: part_of UBERON:0001156 ! ascending colon + +[Term] +id: UBERON:0004991 +name: mucosa of transverse colon +is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001157 ! transverse colon +relationship: part_of UBERON:0001157 ! transverse colon + +[Term] +id: UBERON:0004992 +name: mucosa of descending colon +is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001158 ! descending colon +relationship: part_of UBERON:0001158 ! descending colon + [Term] id: UBERON:0004993 name: mucosa of sigmoid colon @@ -266739,8 +376876,52 @@ synonym: "stomach fundus organ mucosa" EXACT [OBOL:automatic] xref: EMAPA:27151 xref: FMA:17053 is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0001160 ! fundus of stomach +[Term] +id: UBERON:0004995 +name: mucosa of body of stomach +namespace: uberon +def: "A mucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +synonym: "body of stomach mucosa" EXACT [OBOL:automatic] +synonym: "body of stomach mucosa of organ" EXACT [OBOL:automatic] +synonym: "body of stomach mucous membrane" EXACT [OBOL:automatic] +synonym: "body of stomach organ mucosa" EXACT [OBOL:automatic] +synonym: "corpus gastricum (ventriculare) mucosa" EXACT [OBOL:automatic] +synonym: "corpus gastricum (ventriculare) mucosa of organ" EXACT [OBOL:automatic] +synonym: "corpus gastricum (ventriculare) mucous membrane" EXACT [OBOL:automatic] +synonym: "corpus gastricum (ventriculare) organ mucosa" EXACT [OBOL:automatic] +synonym: "gastric body mucosa" EXACT [OBOL:automatic] +synonym: "gastric body mucosa of organ" EXACT [OBOL:automatic] +synonym: "gastric body mucous membrane" EXACT [OBOL:automatic] +synonym: "gastric body organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] +synonym: "mucosa of gastric body" EXACT [OBOL:automatic] +synonym: "mucosa of organ of body of stomach" EXACT [OBOL:automatic] +synonym: "mucosa of organ of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] +synonym: "mucosa of organ of gastric body" EXACT [OBOL:automatic] +synonym: "mucosa of organ of stomach body" EXACT [OBOL:automatic] +synonym: "mucosa of stomach body" EXACT [OBOL:automatic] +synonym: "mucous membrane of body of stomach" EXACT [OBOL:automatic] +synonym: "mucous membrane of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] +synonym: "mucous membrane of gastric body" EXACT [OBOL:automatic] +synonym: "mucous membrane of stomach body" EXACT [OBOL:automatic] +synonym: "organ mucosa of body of stomach" EXACT [OBOL:automatic] +synonym: "organ mucosa of corpus gastricum (ventriculare)" EXACT [OBOL:automatic] +synonym: "organ mucosa of gastric body" EXACT [OBOL:automatic] +synonym: "organ mucosa of stomach body" EXACT [OBOL:automatic] +synonym: "stomach body mucosa" EXACT [OBOL:automatic] +synonym: "stomach body mucosa of organ" EXACT [OBOL:automatic] +synonym: "stomach body mucous membrane" EXACT [OBOL:automatic] +synonym: "stomach body organ mucosa" EXACT [OBOL:automatic] +xref: FMA:17054 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001161 ! body of stomach +relationship: part_of UBERON:0001161 ! body of stomach + [Term] id: UBERON:0004996 name: mucosa of cardia of stomach @@ -266787,8 +376968,47 @@ synonym: "stomach cardiac region mucous membrane" EXACT [OBOL:automatic] synonym: "stomach cardiac region organ mucosa" EXACT [OBOL:automatic] xref: FMA:17456 is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0001162 ! cardia of stomach +[Term] +id: UBERON:0004997 +name: mucosa of pyloric antrum +namespace: uberon +def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +synonym: "antral mucosa" EXACT [BTO:0004107] +synonym: "antrum of stomach mucosa" EXACT [OBOL:automatic] +synonym: "antrum of stomach mucosa of organ" EXACT [OBOL:automatic] +synonym: "antrum of stomach mucous membrane" EXACT [OBOL:automatic] +synonym: "antrum of stomach organ mucosa" EXACT [OBOL:automatic] +synonym: "gastric antrum mucosa" RELATED [BTO:0004107] +synonym: "mucosa of antrum of stomach" EXACT [OBOL:automatic] +synonym: "mucosa of organ of antrum of stomach" EXACT [OBOL:automatic] +synonym: "mucosa of organ of pyloric antrum" EXACT [OBOL:automatic] +synonym: "mucosa of organ of stomach pyloric antrum" EXACT [OBOL:automatic] +synonym: "mucosa of stomach pyloric antrum" EXACT [OBOL:automatic] +synonym: "mucous membrane of antrum of stomach" EXACT [OBOL:automatic] +synonym: "mucous membrane of pyloric antrum" EXACT [OBOL:automatic] +synonym: "mucous membrane of stomach pyloric antrum" EXACT [OBOL:automatic] +synonym: "organ mucosa of antrum of stomach" EXACT [OBOL:automatic] +synonym: "organ mucosa of pyloric antrum" EXACT [OBOL:automatic] +synonym: "organ mucosa of stomach pyloric antrum" EXACT [OBOL:automatic] +synonym: "pyloric antrum mucosa" EXACT [OBOL:automatic] +synonym: "pyloric antrum mucosa of organ" EXACT [OBOL:automatic] +synonym: "pyloric antrum mucous membrane" EXACT [OBOL:automatic] +synonym: "pyloric antrum organ mucosa" EXACT [OBOL:automatic] +synonym: "stomach pyloric antrum mucosa" EXACT [OBOL:automatic] +synonym: "stomach pyloric antrum mucosa of organ" EXACT [OBOL:automatic] +synonym: "stomach pyloric antrum mucous membrane" EXACT [OBOL:automatic] +synonym: "stomach pyloric antrum organ mucosa" EXACT [OBOL:automatic] +xref: BTO:0004107 +xref: FMA:17055 +is_a: UBERON:0004998 ! mucosa of pylorus +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001165 ! pyloric antrum +relationship: part_of UBERON:0001165 ! pyloric antrum + [Term] id: UBERON:0004998 name: mucosa of pylorus @@ -266822,8 +377042,145 @@ xref: BTO:0004110 xref: EMAPA:27199 xref: FMA:17461 is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 ! pylorus +[Term] +id: UBERON:0004999 +name: mucosa of biliary tree +namespace: uberon +def: "A mucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +synonym: "biliary tract mucosa" EXACT [OBOL:automatic] +synonym: "biliary tract mucosa of organ" EXACT [OBOL:automatic] +synonym: "biliary tract mucous membrane" EXACT [OBOL:automatic] +synonym: "biliary tract organ mucosa" EXACT [OBOL:automatic] +synonym: "biliary tree mucosa" EXACT [OBOL:automatic] +synonym: "biliary tree mucosa of organ" EXACT [OBOL:automatic] +synonym: "biliary tree mucous membrane" EXACT [OBOL:automatic] +synonym: "biliary tree organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of biliary tract" EXACT [OBOL:automatic] +synonym: "mucosa of organ of biliary tract" EXACT [OBOL:automatic] +synonym: "mucosa of organ of biliary tree" EXACT [OBOL:automatic] +synonym: "mucous membrane of biliary tract" EXACT [OBOL:automatic] +synonym: "mucous membrane of biliary tree" EXACT [OBOL:automatic] +synonym: "organ mucosa of biliary tract" EXACT [OBOL:automatic] +synonym: "organ mucosa of biliary tree" EXACT [OBOL:automatic] +xref: FMA:14695 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001173 ! biliary tree +relationship: part_of UBERON:0001173 ! biliary tree + +[Term] +id: UBERON:0005000 +name: mucosa of common bile duct +namespace: uberon +def: "A mucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +synonym: "common bile duct mucosa" EXACT [OBOL:automatic] +synonym: "common bile duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "common bile duct mucous membrane" EXACT [OBOL:automatic] +synonym: "common bile duct organ mucosa" EXACT [OBOL:automatic] +synonym: "common bile ductal mucosa" EXACT [FMA:14688] +synonym: "ductus choledochus (biliaris) mucosa" EXACT [OBOL:automatic] +synonym: "ductus choledochus (biliaris) mucosa of organ" EXACT [OBOL:automatic] +synonym: "ductus choledochus (biliaris) mucous membrane" EXACT [OBOL:automatic] +synonym: "ductus choledochus (biliaris) organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] +synonym: "mucosa of organ of common bile duct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of ductus choledochus (biliaris)" EXACT [OBOL:automatic] +synonym: "mucous membrane of common bile duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of ductus choledochus (biliaris)" EXACT [OBOL:automatic] +synonym: "organ mucosa of common bile duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of ductus choledochus (biliaris)" EXACT [OBOL:automatic] +xref: FMA:14688 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001174 ! common bile duct +relationship: part_of UBERON:0001174 ! common bile duct + +[Term] +id: UBERON:0005001 +name: mucosa of common hepatic duct +namespace: uberon +def: "A mucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "common hepatic duct mucosa" EXACT [OBOL:automatic] +synonym: "common hepatic duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "common hepatic duct mucous membrane" EXACT [OBOL:automatic] +synonym: "common hepatic duct organ mucosa" EXACT [OBOL:automatic] +synonym: "common hepatic ductal mucosa" EXACT [FMA:14691] +synonym: "hepatic duct mucosa" EXACT [OBOL:automatic] +synonym: "hepatic duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "hepatic duct mucous membrane" EXACT [OBOL:automatic] +synonym: "hepatic duct organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of hepatic duct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of common hepatic duct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of hepatic duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of common hepatic duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of hepatic duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of common hepatic duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of hepatic duct" EXACT [OBOL:automatic] +xref: FMA:14691 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001175 ! common hepatic duct +relationship: part_of UBERON:0001175 ! common hepatic duct + +[Term] +id: UBERON:0005002 +name: mucosa of right hepatic duct +namespace: uberon +def: "A mucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "mucosa of organ of right hepatic duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of right hepatic duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of right hepatic duct" EXACT [OBOL:automatic] +synonym: "right hepatic duct mucosa" EXACT [OBOL:automatic] +synonym: "right hepatic duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "right hepatic duct mucous membrane" EXACT [OBOL:automatic] +synonym: "right hepatic duct organ mucosa" EXACT [OBOL:automatic] +synonym: "right hepatic ductal mucosa" EXACT [FMA:14692] +xref: FMA:14692 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001176 ! right hepatic duct +relationship: part_of UBERON:0001176 ! right hepatic duct + +[Term] +id: UBERON:0005003 +name: mucosa of left hepatic duct +namespace: uberon +def: "A mucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +synonym: "left hepatic duct mucosa" EXACT [OBOL:automatic] +synonym: "left hepatic duct mucosa of organ" EXACT [OBOL:automatic] +synonym: "left hepatic duct mucous membrane" EXACT [OBOL:automatic] +synonym: "left hepatic duct organ mucosa" EXACT [OBOL:automatic] +synonym: "left hepatic ductal mucosa" EXACT [FMA:14693] +synonym: "mucosa of organ of left hepatic duct" EXACT [OBOL:automatic] +synonym: "mucous membrane of left hepatic duct" EXACT [OBOL:automatic] +synonym: "organ mucosa of left hepatic duct" EXACT [OBOL:automatic] +xref: FMA:14693 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001177 ! left hepatic duct +relationship: part_of UBERON:0001177 ! left hepatic duct + +[Term] +id: UBERON:0005004 +name: mucosa of right ureter +is_a: UBERON:0004980 ! mucosa of ureter +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001222 ! right ureter +relationship: part_of UBERON:0001222 ! right ureter + +[Term] +id: UBERON:0005005 +name: mucosa of left ureter +is_a: UBERON:0004980 ! mucosa of ureter +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001223 ! left ureter +relationship: part_of UBERON:0001223 ! left ureter + [Term] id: UBERON:0005006 name: mucosa of renal pelvis @@ -266862,6 +377219,90 @@ intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001224 ! renal pelvis relationship: part_of UBERON:0001224 ! renal pelvis +[Term] +id: UBERON:0005009 +name: mucosa of trigone of urinary bladder +is_a: UBERON:0001259 ! mucosa of urinary bladder +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001257 ! trigone of urinary bladder +relationship: part_of UBERON:0001257 ! trigone of urinary bladder + +[Term] +id: UBERON:0005010 +name: mucosa of neck of urinary bladder +is_a: UBERON:0001259 ! mucosa of urinary bladder +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001258 ! neck of urinary bladder +relationship: part_of UBERON:0001258 ! neck of urinary bladder + +[Term] +id: UBERON:0005011 +name: mucosa of right uterine tube +namespace: uberon +def: "A mucosa that is part of a right uterine tube [Automatically generated definition]." [OBOL:automatic] +synonym: "mucosa of organ of right fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of organ of right oviduct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of right uterine tube" EXACT [OBOL:automatic] +synonym: "mucosa of right fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of right oviduct" EXACT [OBOL:automatic] +synonym: "mucous membrane of right fallopian tube" EXACT [OBOL:automatic] +synonym: "mucous membrane of right oviduct" EXACT [OBOL:automatic] +synonym: "mucous membrane of right uterine tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of right fallopian tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of right oviduct" EXACT [OBOL:automatic] +synonym: "organ mucosa of right uterine tube" EXACT [OBOL:automatic] +synonym: "right fallopian tube mucosa" EXACT [OBOL:automatic] +synonym: "right fallopian tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "right fallopian tube mucous membrane" EXACT [OBOL:automatic] +synonym: "right fallopian tube organ mucosa" EXACT [OBOL:automatic] +synonym: "right oviduct mucosa" EXACT [OBOL:automatic] +synonym: "right oviduct mucosa of organ" EXACT [OBOL:automatic] +synonym: "right oviduct mucous membrane" EXACT [OBOL:automatic] +synonym: "right oviduct organ mucosa" EXACT [OBOL:automatic] +synonym: "right uterine tube mucosa" EXACT [OBOL:automatic] +synonym: "right uterine tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "right uterine tube mucous membrane" EXACT [OBOL:automatic] +synonym: "right uterine tube organ mucosa" EXACT [OBOL:automatic] +xref: FMA:18452 +is_a: UBERON:0005048 ! mucosa of uterine tube +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001302 ! right uterine tube +relationship: part_of UBERON:0001302 ! right uterine tube + +[Term] +id: UBERON:0005012 +name: mucosa of left uterine tube +namespace: uberon +def: "A mucosa that is part of a left uterine tube [Automatically generated definition]." [OBOL:automatic] +synonym: "left fallopian tube mucosa" EXACT [OBOL:automatic] +synonym: "left fallopian tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "left fallopian tube mucous membrane" EXACT [OBOL:automatic] +synonym: "left fallopian tube organ mucosa" EXACT [OBOL:automatic] +synonym: "left oviduct mucosa" EXACT [OBOL:automatic] +synonym: "left oviduct mucosa of organ" EXACT [OBOL:automatic] +synonym: "left oviduct mucous membrane" EXACT [OBOL:automatic] +synonym: "left oviduct organ mucosa" EXACT [OBOL:automatic] +synonym: "left uterine tube mucosa" EXACT [OBOL:automatic] +synonym: "left uterine tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "left uterine tube mucous membrane" EXACT [OBOL:automatic] +synonym: "left uterine tube organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of left fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of left oviduct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of left fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of organ of left oviduct" EXACT [OBOL:automatic] +synonym: "mucosa of organ of left uterine tube" EXACT [OBOL:automatic] +synonym: "mucous membrane of left fallopian tube" EXACT [OBOL:automatic] +synonym: "mucous membrane of left oviduct" EXACT [OBOL:automatic] +synonym: "mucous membrane of left uterine tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of left fallopian tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of left oviduct" EXACT [OBOL:automatic] +synonym: "organ mucosa of left uterine tube" EXACT [OBOL:automatic] +xref: FMA:18453 +is_a: UBERON:0005048 ! mucosa of uterine tube +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001303 ! left uterine tube +relationship: part_of UBERON:0001303 ! left uterine tube + [Term] id: UBERON:0005013 name: mucosa of male urethra @@ -266876,6 +377317,8 @@ synonym: "mucous membrane of male urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of male urethra" EXACT [OBOL:automatic] xref: FMA:239937 is_a: UBERON:0012299 ! mucosa of urethra +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001333 ! male urethra relationship: part_of UBERON:0001333 ! male urethra [Term] @@ -266892,6 +377335,8 @@ synonym: "mucous membrane of female urethra" EXACT [OBOL:automatic] synonym: "organ mucosa of female urethra" EXACT [OBOL:automatic] xref: FMA:239940 is_a: UBERON:0012299 ! mucosa of urethra +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001334 ! female urethra relationship: part_of UBERON:0001334 ! female urethra [Term] @@ -266918,8 +377363,18 @@ synonym: "prostatic urethral mucosa" EXACT [FMA:77079] synonym: "tunica mucosa urethrae prosticae" EXACT LATIN [FMA:77079, FMA:TA] xref: FMA:77079 is_a: UBERON:0005013 ! mucosa of male urethra +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001335 ! prostatic urethra relationship: part_of UBERON:0001335 ! prostatic urethra +[Term] +id: UBERON:0005017 +name: mucosa of lacrimal sac +is_a: UBERON:0005043 ! mucosa of nasolacrimal duct +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001351 ! lacrimal sac +relationship: part_of UBERON:0001351 ! lacrimal sac + [Term] id: UBERON:0005019 name: mucosa of palate @@ -266951,6 +377406,8 @@ synonym: "roof of mouth organ mucosa" EXACT [OBOL:automatic] xref: FMA:59765 is_a: UBERON:0003729 ! mouth mucosa is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001716 ! secondary palate relationship: part_of UBERON:0001716 ! secondary palate [Term] @@ -266976,6 +377433,92 @@ intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001723 ! tongue relationship: part_of UBERON:0001723 ! tongue +[Term] +id: UBERON:0005021 +name: mucosa of sphenoidal sinus +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: located_in UBERON:0001724 ! sphenoidal sinus +relationship: located_in UBERON:0001724 ! sphenoidal sinus +relationship: part_of UBERON:0000033 ! head + +[Term] +id: UBERON:0005022 +name: mucosa of nasopharynx +is_a: UBERON:0000355 ! pharyngeal mucosa +is_a: UBERON:0000379 ! tracheal mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx + +[Term] +id: UBERON:0005023 +name: mucosa of oropharynx +is_a: UBERON:0000355 ! pharyngeal mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0004786 ! gastrointestinal system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx + +[Term] +id: UBERON:0005024 +name: mucosa of soft palate +is_a: UBERON:0005019 ! mucosa of palate +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0001733 ! soft palate + +[Term] +id: UBERON:0005025 +name: mucosa of uvula +is_a: UBERON:0005024 ! mucosa of soft palate +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001734 ! palatine uvula +relationship: part_of UBERON:0001734 ! palatine uvula + +[Term] +id: UBERON:0005026 +name: mucosa of middle ear +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001756 ! middle ear +relationship: part_of UBERON:0001756 ! middle ear + +[Term] +id: UBERON:0005027 +name: mucosa of frontal sinus +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: located_in UBERON:0001760 ! frontal sinus +relationship: located_in UBERON:0001760 ! frontal sinus + +[Term] +id: UBERON:0005028 +name: mucosa of maxillary sinus +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: located_in UBERON:0001764 ! maxillary sinus +relationship: located_in UBERON:0001764 ! maxillary sinus + +[Term] +id: UBERON:0005030 +name: mucosa of paranasal sinus +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: adjacent_to UBERON:0001825 ! paranasal sinus +relationship: adjacent_to UBERON:0001825 ! paranasal sinus + +[Term] +id: UBERON:0005031 +name: mucosa of upper lip +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0036294 ! mucosa of lip +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0001834 ! upper lip +relationship: part_of UBERON:0001834 ! upper lip + [Term] id: UBERON:0005032 name: mucosa of lower lip @@ -267001,6 +377544,76 @@ intersection_of: UBERON:0000344 ! mucosa intersection_of: part_of UBERON:0001835 ! lower lip relationship: part_of UBERON:0001835 ! lower lip +[Term] +id: UBERON:0005033 +name: mucosa of gallbladder +namespace: uberon +def: "A mucosa that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +synonym: "gall bladder mucosa" EXACT [OBOL:automatic] +synonym: "gall bladder mucosa of organ" EXACT [OBOL:automatic] +synonym: "gall bladder mucous membrane" EXACT [OBOL:automatic] +synonym: "gall bladder organ mucosa" EXACT [OBOL:automatic] +synonym: "gallbladder mucosa" EXACT [OBOL:automatic] +synonym: "gallbladder mucosa of organ" EXACT [OBOL:automatic] +synonym: "gallbladder mucous membrane" EXACT [OBOL:automatic] +synonym: "gallbladder organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of gall bladder" EXACT [OBOL:automatic] +synonym: "mucosa of organ of gall bladder" EXACT [OBOL:automatic] +synonym: "mucosa of organ of gallbladder" EXACT [OBOL:automatic] +synonym: "mucous membrane of gall bladder" EXACT [OBOL:automatic] +synonym: "mucous membrane of gallbladder" EXACT [OBOL:automatic] +synonym: "organ mucosa of gall bladder" EXACT [OBOL:automatic] +synonym: "organ mucosa of gallbladder" EXACT [OBOL:automatic] +synonym: "tunica mucosa (vesica biliaris)" EXACT [FMA:14662] +synonym: "tunica mucosa vesicae biliaris" EXACT LATIN [FMA:14662, FMA:TA] +xref: FMA:14662 +xref: SCTID:362196002 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder + +[Term] +id: UBERON:0005034 +name: mucosa of right main bronchus +is_a: UBERON:0005036 ! mucosa of main bronchus +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002177 ! right main bronchus +relationship: part_of UBERON:0002177 ! right main bronchus + +[Term] +id: UBERON:0005035 +name: mucosa of left main bronchus +is_a: UBERON:0005036 ! mucosa of main bronchus +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002178 ! left main bronchus +relationship: part_of UBERON:0002178 ! left main bronchus + +[Term] +id: UBERON:0005036 +name: mucosa of main bronchus +is_a: UBERON:0000410 ! bronchial mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + +[Term] +id: UBERON:0005037 +name: mucosa of lobar bronchus +is_a: UBERON:0000410 ! bronchial mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus + +[Term] +id: UBERON:0005038 +name: mucosa of segmental bronchus +is_a: UBERON:0000410 ! bronchial mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002184 ! segmental bronchus +relationship: part_of UBERON:0002184 ! segmental bronchus + [Term] id: UBERON:0005039 name: mucosa of bronchiole @@ -267025,8 +377638,79 @@ xref: FMA:263230 xref: FMA:62774 xref: SCTID:10887006 is_a: UBERON:0000410 ! bronchial mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002186 ! bronchiole relationship: part_of UBERON:0002186 ! bronchiole +[Term] +id: UBERON:0005040 +name: mucosa of terminal bronchiole +namespace: uberon +def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +synonym: "bronchiolus terminalis mucosa" EXACT [OBOL:automatic] +synonym: "bronchiolus terminalis mucosa of organ" EXACT [OBOL:automatic] +synonym: "bronchiolus terminalis mucous membrane" EXACT [OBOL:automatic] +synonym: "bronchiolus terminalis organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "mucosa of organ of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "mucosa of organ of terminal bronchiole" EXACT [OBOL:automatic] +synonym: "mucous membrane of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "mucous membrane of terminal bronchiole" EXACT [OBOL:automatic] +synonym: "organ mucosa of bronchiolus terminalis" EXACT [OBOL:automatic] +synonym: "organ mucosa of terminal bronchiole" EXACT [OBOL:automatic] +synonym: "terminal bronchiole mucosa" EXACT [OBOL:automatic] +synonym: "terminal bronchiole mucosa of organ" EXACT [OBOL:automatic] +synonym: "terminal bronchiole mucous membrane" EXACT [OBOL:automatic] +synonym: "terminal bronchiole organ mucosa" EXACT [OBOL:automatic] +xref: FMA:263232 +is_a: UBERON:0005039 ! mucosa of bronchiole +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002187 ! terminal bronchiole +relationship: part_of UBERON:0002187 ! terminal bronchiole + +[Term] +id: UBERON:0005041 +name: mucosa of respiratory bronchiole +is_a: UBERON:0005039 ! mucosa of bronchiole +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002188 ! respiratory bronchiole +relationship: part_of UBERON:0002188 ! respiratory bronchiole + +[Term] +id: UBERON:0005042 +name: inner epithelial layer of tympanic membrane +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0009647 ! tympanic membrane epithelium +intersection_of: UBERON:0009647 ! tympanic membrane epithelium +intersection_of: part_of UBERON:0010063 ! tympanic cavity epithelium +relationship: part_of UBERON:0010063 ! tympanic cavity epithelium + +[Term] +id: UBERON:0005043 +name: mucosa of nasolacrimal duct +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002392 ! nasolacrimal duct +relationship: part_of UBERON:0002392 ! nasolacrimal duct + +[Term] +id: UBERON:0005044 +name: mucosa of pharyngotympanic tube +is_a: UBERON:0005026 ! mucosa of middle ear +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: part_of UBERON:0002393 ! pharyngotympanic tube + +[Term] +id: UBERON:0005045 +name: mucosa of ethmoidal sinus +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: located_in UBERON:0002453 ! ethmoid sinus +relationship: located_in UBERON:0002453 ! ethmoid sinus + [Term] id: UBERON:0005046 name: mucosa of hard palate @@ -267039,8 +377723,69 @@ synonym: "organ mucosa of hard palate" EXACT [OBOL:automatic] xref: FMA:59783 xref: SCTID:245841005 is_a: UBERON:0005019 ! mucosa of palate +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0003216 ! hard palate relationship: part_of UBERON:0003216 ! hard palate +[Term] +id: UBERON:0005047 +name: mucosa of vocal fold +is_a: UBERON:0001824 ! mucosa of larynx +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0003706 ! laryngeal vocal fold +relationship: part_of UBERON:0003706 ! laryngeal vocal fold + +[Term] +id: UBERON:0005048 +name: mucosa of uterine tube +namespace: uberon +def: "A mucosa that is part of a fallopian tube [Automatically generated definition]." [OBOL:automatic] +synonym: "fallopian tube mucosa" EXACT [OBOL:automatic] +synonym: "fallopian tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "fallopian tube mucous membrane" EXACT [OBOL:automatic] +synonym: "fallopian tube organ mucosa" EXACT [OBOL:automatic] +synonym: "mucosa of fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of organ of fallopian tube" EXACT [OBOL:automatic] +synonym: "mucosa of organ of uterine tube" EXACT [OBOL:automatic] +synonym: "mucosa of oviduct" EXACT [FMA:18319] +synonym: "mucous membrane of fallopian tube" EXACT [OBOL:automatic] +synonym: "mucous membrane of uterine tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of fallopian tube" EXACT [OBOL:automatic] +synonym: "organ mucosa of uterine tube" EXACT [OBOL:automatic] +synonym: "tunica mucosa tubae uterinae" EXACT LATIN [FMA:18319, FMA:TA] +synonym: "uterine tubal mucosa" EXACT [FMA:18319] +synonym: "uterine tube mucosa" EXACT [OBOL:automatic] +synonym: "uterine tube mucosa of organ" EXACT [OBOL:automatic] +synonym: "uterine tube mucous membrane" EXACT [OBOL:automatic] +synonym: "uterine tube organ mucosa" EXACT [OBOL:automatic] +xref: FMA:18319 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 ! fallopian tube + +[Term] +id: UBERON:0005049 +name: mucosa of infundibulum of uterine tube +namespace: uberon +def: "A mucosa that is part of a uterine tube infundibulum [Automatically generated definition]." [OBOL:automatic] +synonym: "mucosa of infundibulum of fallopian tube" EXACT [FMA:18357] +synonym: "mucosa of infundibulum of oviduct" EXACT [FMA:18357] +synonym: "mucosa of organ of uterine tube infundibulum" EXACT [OBOL:automatic] +synonym: "mucosa of uterine tube infundibulum" EXACT [OBOL:automatic] +synonym: "mucous membrane of uterine tube infundibulum" EXACT [OBOL:automatic] +synonym: "organ mucosa of uterine tube infundibulum" EXACT [OBOL:automatic] +synonym: "uterine tube infundibulum mucosa" EXACT [OBOL:automatic] +synonym: "uterine tube infundibulum mucosa of organ" EXACT [OBOL:automatic] +synonym: "uterine tube infundibulum mucous membrane" EXACT [OBOL:automatic] +synonym: "uterine tube infundibulum organ mucosa" EXACT [OBOL:automatic] +xref: FMA:18357 +is_a: UBERON:0019042 ! reproductive system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0003984 ! uterine tube infundibulum +relationship: part_of UBERON:0003984 ! uterine tube infundibulum + [Term] id: UBERON:0005051 name: mediastinum testis @@ -267057,6 +377802,8 @@ xref: SCTID:362279007 xref: Wikipedia:Mediastinum_testis is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure +relationship: has_part UBERON:0002384 ! connective tissue +relationship: overlaps UBERON:0003728 ! mediastinum relationship: part_of UBERON:0000473 ! testis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg xsd:anyURI @@ -267088,6 +377835,8 @@ subset: uberon_slim synonym: "long bone zone" EXACT [] xref: FMA:24008 is_a: UBERON:0005913 ! zone of bone organ +intersection_of: UBERON:0005913 ! zone of bone organ +intersection_of: part_of UBERON:0002495 ! long bone relationship: part_of UBERON:0002495 ! long bone [Term] @@ -267157,6 +377906,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0814992 xref: http://www.snomedbrowser.com/Codes/Details/361463007 xref: NCIT:C34224 xref: Neural:groove +xref: neuronames:1363 xref: SCTID:361463007 xref: UMLS:C0814992 {source="ncithesaurus:Neural_Groove"} xref: Wikipedia:Neural_groove @@ -267164,8 +377914,8 @@ xref: XAO:0000248 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0003075 ! neural plate -property_value: UBPROP:0000001 "The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]." xsd:string {source="Neural:groove"} property_value: UBPROP:0000001 "The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]." xsd:string {source="Wikipedia:Neural_groove"} +property_value: UBPROP:0000001 "The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]." xsd:string {source="Neural:groove"} [Term] id: UBERON:0005062 @@ -267182,6 +377932,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0814993 xref: http://www.snomedbrowser.com/Codes/Details/361461009 xref: NCIT:C34223 xref: Neural:fold +xref: neuronames:1364 xref: SCTID:361461009 xref: UMLS:C0814993 {source="ncithesaurus:Neural_Fold"} xref: Wikipedia:Neural_fold @@ -267196,6 +377947,22 @@ relationship: part_of UBERON:0005061 ! neural groove property_value: UBPROP:0000001 "In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]." xsd:string {source="Wikipedia:Neural_fold"} property_value: UBPROP:0000001 "In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]." xsd:string {source="Neural:fold"} +[Term] +id: UBERON:0005064 +name: left ventricular trabecular myocardium +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: part_of UBERON:0002084 ! heart left ventricle +relationship: part_of UBERON:0003382 ! cardiac muscle of left ventricle + +[Term] +id: UBERON:0005066 +name: right ventricular trabecular myocardium +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: part_of UBERON:0002080 ! heart right ventricle +relationship: part_of UBERON:0003381 ! cardiac muscle of right ventricle + [Term] id: UBERON:0005068 name: neural rod @@ -267304,7 +378071,7 @@ xref: EHDAA2:0000903 xref: EHDAA:1983 xref: EHDAA:2661 xref: EMAPA:16904 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=208 +xref: neuronames:208 xref: VHOG:0001547 xref: Wikipedia:Lamina_terminalis is_a: UBERON:0005291 ! embryonic tissue @@ -267395,8 +378162,11 @@ synonym: "hair placode" EXACT [DOI:10.1016/j.cub.2008.12.005] synonym: "vibrissa placode" NARROW [] xref: EMAPA:36479 is_a: UBERON:0011817 ! skin appendage placode +intersection_of: UBERON:0005085 ! ectodermal placode +intersection_of: has_potential_to_develop_into UBERON:0002073 ! hair follicle relationship: develops_from UBERON:0001003 ! skin epidermis relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer +relationship: has_potential_to_develop_into UBERON:0002073 ! hair follicle property_value: UBPROP:0000001 "An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud[GO]." xsd:string {source="GO:0060789"} [Term] @@ -267416,6 +378186,11 @@ xref: TAO:0001153 xref: ZFA:0001153 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode +intersection_of: UBERON:0005085 ! ectodermal placode +intersection_of: has_potential_to_develop_into UBERON:0001091 ! calcareous tooth +relationship: has_developmental_contribution_from UBERON:0004362 ! pharyngeal arch 1 +relationship: has_potential_to_develop_into UBERON:0001091 ! calcareous tooth +relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! jaw region property_value: UBPROP:0000001 "Placode that develops into a tooth. The placode is a thickening of the pharyngeal epithelium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001153", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000015 "In mammals this may be located in the alveolar ridges, but note that some species such as zebrafish have ceratobranchial teeth. Sharks have dermal denticles that share developmental origins. Currently we don't include location information due to this diversity, but in future we may include specific subclasses and/or taxon GCIs." xsd:string @@ -267426,7 +378201,10 @@ namespace: uberon def: "A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO]." [GO:0060791] is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode +intersection_of: UBERON:0005085 ! ectodermal placode +intersection_of: has_potential_to_develop_into UBERON:0001821 ! sebaceous gland relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer +relationship: has_potential_to_develop_into UBERON:0001821 ! sebaceous gland property_value: editor_note "TODO - add bud" xsd:string [Term] @@ -267436,7 +378214,10 @@ namespace: uberon def: "An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO]." [GO:0060793] is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode +intersection_of: UBERON:0005085 ! ectodermal placode +intersection_of: has_potential_to_develop_into UBERON:0001820 ! sweat gland relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer +relationship: has_potential_to_develop_into UBERON:0001820 ! sweat gland property_value: editor_note "TODO - add bud" xsd:string [Term] @@ -267466,7 +378247,6 @@ xref: EHDAA:484 xref: EMAPA:16239 xref: FMA:70318 xref: VHOG:0000489 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 {source="FMA"} ! embryonic structure relationship: in_right_side_of UBERON:0002063 ! sinus venosus property_value: UBPROP:0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000489", ontology="VHOG", source="DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003", source="http://bgee.unil.ch/"} @@ -267497,6 +378277,13 @@ is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0007687 {source="GO"} ! kidney field property_value: editor_note "class added for consistency with GO - consider merging with kidney mesenchyme." xsd:string +[Term] +id: UBERON:0005096 +name: descending thin limb +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000064 ! organ part +relationship: part_of UBERON:0004136 ! intermediate tubule + [Term] id: UBERON:0005103 name: mesonephric epithelium @@ -267542,6 +378329,131 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros +[Term] +id: UBERON:0005110 +name: metanephric nephron +is_a: UBERON:0001285 ! nephron +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001285 ! nephron +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: develops_from UBERON:0003220 ! metanephric mesenchyme +relationship: immediate_transformation_of UBERON:0010535 ! primitive metanephric nephron +relationship: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0005111 +name: metanephric pyramid +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004200 ! kidney pyramid +intersection_of: UBERON:0004200 ! kidney pyramid +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0005113 +name: metanephric cortex mesenchyme +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: develops_from UBERON:0010531 ! metanephros induced blastemal cells + +[Term] +id: UBERON:0005115 +name: metanephric cortical collecting duct +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004203 ! cortical collecting duct +intersection_of: UBERON:0004203 ! cortical collecting duct +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0004737 ! metanephric collecting duct +relationship: part_of UBERON:0010533 ! metanephros cortex + +[Term] +id: UBERON:0005116 +name: metanephric descending thin limb +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005096 ! descending thin limb +intersection_of: UBERON:0005096 ! descending thin limb +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005130 ! metanephric loop of Henle + +[Term] +id: UBERON:0005117 +name: metanephric distal convoluted tubule +is_a: UBERON:0001292 ! distal convoluted tubule +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0001292 ! distal convoluted tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0010533 ! metanephros cortex + +[Term] +id: UBERON:0005124 +name: metanephric proximal convoluted tubule +is_a: UBERON:0001287 ! proximal convoluted tubule +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0001287 ! proximal convoluted tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0010533 ! metanephros cortex + +[Term] +id: UBERON:0005125 +name: metanephric proximal straight tubule +is_a: UBERON:0001290 ! proximal straight tubule +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0001290 ! proximal straight tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005151 ! metanephric proximal tubule + +[Term] +id: UBERON:0005129 +name: metanephric distal tubule +is_a: UBERON:0004135 ! distal tubule +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0004135 ! distal tubule +intersection_of: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0005130 +name: metanephric loop of Henle +is_a: UBERON:0001288 ! loop of Henle +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0001288 ! loop of Henle +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0004136 ! intermediate tubule + +[Term] +id: UBERON:0005133 +name: metanephric glomerulus vasculature +is_a: UBERON:0004190 ! renal glomerulus vasculature +intersection_of: UBERON:0004190 ! renal glomerulus vasculature +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0004736 ! metanephric glomerulus + +[Term] +id: UBERON:0005134 +name: metanephric nephron epithelium +is_a: UBERON:0004211 ! nephron epithelium +is_a: UBERON:0005108 ! metanephric epithelium +intersection_of: UBERON:0004211 ! nephron epithelium +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005110 ! metanephric nephron + +[Term] +id: UBERON:0005135 +name: metanephric glomerular epithelium +is_a: UBERON:0004188 ! glomerular epithelium +is_a: UBERON:0005134 ! metanephric nephron epithelium +intersection_of: UBERON:0004188 ! glomerular epithelium +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0004736 ! metanephric glomerulus + +[Term] +id: UBERON:0005136 +name: metanephric glomerular endothelium +is_a: UBERON:0004189 ! glomerular endothelium +is_a: UBERON:0005135 ! metanephric glomerular epithelium +intersection_of: UBERON:0004189 ! glomerular endothelium +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005133 ! metanephric glomerulus vasculature + [Term] id: UBERON:0005137 name: metanephric capsule @@ -267554,6 +378466,60 @@ intersection_of: UBERON:0002015 ! kidney capsule intersection_of: part_of UBERON:0000081 ! metanephros relationship: part_of UBERON:0000081 ! metanephros +[Term] +id: UBERON:0005144 +name: metanephric glomerular capillary +is_a: UBERON:0004212 ! glomerular capillary +intersection_of: UBERON:0004212 ! glomerular capillary +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0004736 ! metanephric glomerulus +relationship: part_of UBERON:0005110 ! metanephric nephron + +[Term] +id: UBERON:0005145 +name: metanephric comma-shaped body +is_a: UBERON:0004198 ! comma-shaped body +intersection_of: UBERON:0004198 ! comma-shaped body +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0005146 +name: metanephric nephron tubule +is_a: UBERON:0001231 ! nephron tubule +is_a: UBERON:0005106 ! metanephric tubule +is_a: UBERON:0005134 ! metanephric nephron epithelium +intersection_of: UBERON:0001231 ! nephron tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: develops_from UBERON:0003220 ! metanephric mesenchyme + +[Term] +id: UBERON:0005147 +name: metanephric renal vesicle +is_a: UBERON:0004209 ! renal vesicle +is_a: UBERON:0005108 ! metanephric epithelium +intersection_of: UBERON:0004209 ! renal vesicle +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme +relationship: has_potential_to_develop_into UBERON:0005134 ! metanephric nephron epithelium + +[Term] +id: UBERON:0005148 +name: metanephric S-shaped body +is_a: UBERON:0004199 ! S-shaped body +intersection_of: UBERON:0004199 ! S-shaped body +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005110 ! metanephric nephron + +[Term] +id: UBERON:0005151 +name: metanephric proximal tubule +is_a: UBERON:0004134 ! proximal tubule +is_a: UBERON:0005146 ! metanephric nephron tubule +intersection_of: UBERON:0004134 ! proximal tubule +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0010533 ! metanephros cortex + [Term] id: UBERON:0005153 name: epithelial bud @@ -267677,6 +378643,7 @@ id: UBERON:0005168 name: renal interlobular vein namespace: uberon def: "Any of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins." [ISBN:0-683-40008-8, MP:0011326] +subset: human_reference_atlas subset: pheno_slim synonym: "interlobular vein" EXACT [MA:0002594] synonym: "interlobular veins of kidney" RELATED [FMA:71634] @@ -267691,18 +378658,21 @@ is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel relationship: part_of UBERON:0001225 ! cortex of kidney property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005169 name: interstitial tissue namespace: uberon def: "Connective tissue between the cellular elements of a structure." [http://medical-dictionary.thefreedictionary.com/tissue] +subset: human_reference_atlas subset: pheno_slim synonym: "interstitium" EXACT [] xref: FMA:86301 xref: SCTID:85293002 is_a: UBERON:0003891 {source="FMA"} ! stroma property_value: editor_note "specify differentia from stroma" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "interstital" xsd:string [Term] @@ -267724,6 +378694,8 @@ xref: SCTID:245399002 xref: UMLS:C0917710 {source="ncithesaurus:Hepatic_Duct"} xref: VHOG:0000219 is_a: UBERON:0002394 ! bile duct +relationship: connects UBERON:0001174 ! common bile duct +relationship: connects UBERON:0002107 ! liver property_value: editor_note "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same" xsd:string property_value: UBPROP:0000001 "A duct that carries bile from the liver to the small intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001100", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000001 "The excretory duct of the liver or one of its branches in the lobes of the liver. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000219", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/hepatic+duct"} @@ -267783,6 +378755,8 @@ subset: organ_slim xref: EMAPA:37272 {source="MA:th"} xref: MA:0000552 is_a: UBERON:0005181 ! thoracic segment organ +intersection_of: UBERON:0000062 ! organ +intersection_of: part_of UBERON:0001443 ! chest relationship: part_of UBERON:0001443 ! chest [Term] @@ -267802,7 +378776,7 @@ xref: CALOHA:TS-0271 xref: EMAPA:32888 xref: FMA:312389 xref: MA:0001604 -xref: MESH:A14.254.900.720.265 +xref: MESH:D004658 xref: SCTID:362863002 xref: TAO:0005138 xref: Wikipedia:Enamel_organ @@ -267894,8 +378868,33 @@ xref: Wikipedia:Bone_marrow_of_ovary_(hair) is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0001037 ! strand of hair relationship: part_of UBERON:0001037 ! strand of hair +[Term] +id: UBERON:0005185 +name: renal medulla collecting duct +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0013522 ! subdivision of tube +intersection_of: UBERON:0013522 ! subdivision of tube +intersection_of: part_of UBERON:0000362 ! renal medulla +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule +relationship: part_of UBERON:0000362 ! renal medulla +relationship: part_of UBERON:0001232 ! collecting duct of renal tubule + +[Term] +id: UBERON:0005192 +name: deferent duct artery +is_a: UBERON:0004573 ! systemic artery +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001000 ! vas deferens +relationship: branching_part_of UBERON:0001310 ! umbilical artery +relationship: branching_part_of UBERON:0001312 ! superior vesical artery +relationship: part_of UBERON:0005352 ! spermatic cord +relationship: supplies UBERON:0001000 ! vas deferens + [Term] id: UBERON:0005193 name: ethmoidal artery @@ -267930,11 +378929,21 @@ is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk +[Term] +id: UBERON:0005195 +name: deferent duct vein +is_a: UBERON:0001638 ! vein +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001000 ! vas deferens +relationship: part_of UBERON:0001000 ! vas deferens + [Term] id: UBERON:0005196 name: spleen germinal center namespace: uberon def: "A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen." [CL:tm, https://github.com/obophenotype/uberon/issues/6] +subset: human_reference_atlas subset: pheno_slim synonym: "germinal center of spleen" EXACT [] synonym: "spleen follicle center" EXACT [MP:0008474] @@ -267947,6 +378956,7 @@ xref: UMLS:C1710156 {source="ncithesaurus:Spleen_Germinal_Center"} is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0004042 {source="CL:tm"} ! spleen secondary B follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005199 @@ -267955,6 +378965,8 @@ namespace: uberon def: "A mammary gland that is part of a cervical region." [OBOL:automatic] xref: MA:0000789 is_a: UBERON:0001911 ! mammary gland +intersection_of: UBERON:0001911 ! mammary gland +intersection_of: part_of UBERON:0005434 ! cervical region relationship: part_of UBERON:0005434 ! cervical region property_value: UBPROP:0000008 "mice have a single pair of cervical mammary glands" xsd:string @@ -267977,6 +378989,8 @@ xref: SCTID:31448001 xref: Wikipedia:Mammary_gland#Other_mammals is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005175 ! chest organ +intersection_of: UBERON:0001911 ! mammary gland +intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0000310 {source="BTO"} ! breast property_value: UBPROP:0000008 "Most primates have one pair of mammary glands, which are thoracic." xsd:string property_value: UBPROP:0000202 FMA:57983 @@ -267986,6 +379000,7 @@ id: UBERON:0005203 name: trachea gland namespace: uberon def: "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://github.com/obophenotype/uberon/issues/1197, ISBN:1451113412, MGI:Anna, PMID:15973734] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "glandula trachealis" EXACT [FMA:7473] @@ -267995,10 +379010,12 @@ xref: EMAPA:36574 xref: FMA:7473 xref: MA:0002937 xref: SCTID:197423006 -is_a: UBERON:0004119 ! endoderm-derived structure -is_a: UBERON:0011148 ! submucosal gland -is_a: UBERON:0036225 ! respiratory system gland +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: has_part CL:0000159 ! seromucus secreting cell +intersection_of: part_of UBERON:0002202 ! submucosa of trachea relationship: part_of UBERON:0002202 ! submucosa of trachea +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "These glands secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents." xsd:string [Term] @@ -268016,6 +379033,36 @@ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0004778 ! larynx submucosa relationship: part_of UBERON:0004778 ! larynx submucosa +[Term] +id: UBERON:0005205 +name: lamina propria of vagina +is_a: UBERON:0000030 ! lamina propria +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + +[Term] +id: UBERON:0005206 +name: choroid plexus stroma +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0001886 ! choroid plexus +relationship: has_part CL:0000235 ! macrophage +relationship: has_part CL:0000451 ! dendritic cell +relationship: part_of UBERON:0001886 ! choroid plexus + +[Term] +id: UBERON:0005207 +name: tonsil capsule +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0003893 ! capsule +intersection_of: UBERON:0003893 ! capsule +intersection_of: part_of UBERON:0002372 ! tonsil +relationship: part_of UBERON:0002372 ! tonsil + [Term] id: UBERON:0005208 name: right atrium valve @@ -268029,8 +379076,19 @@ xref: EMAPA:17327 xref: MA:0001871 is_a: UBERON:0003978 ! valve is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0003978 ! valve +intersection_of: part_of UBERON:0002078 ! right cardiac atrium relationship: part_of UBERON:0002078 ! right cardiac atrium +[Term] +id: UBERON:0005211 +name: renal medulla interstitium +is_a: UBERON:0005215 ! kidney interstitium +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: part_of UBERON:0000362 ! renal medulla +relationship: capable_of_part_of GO:0070295 ! renal water absorption +relationship: part_of UBERON:0000362 ! renal medulla + [Term] id: UBERON:0005212 name: Leydig cell region of testis @@ -268048,13 +379106,36 @@ xref: SCTID:362280005 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0005169 ! interstitial tissue +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: composed_primarily_of CL:0000178 ! Leydig cell +intersection_of: part_of UBERON:0000473 ! testis +relationship: composed_primarily_of CL:0000178 ! Leydig cell +relationship: contributes_to_morphology_of UBERON:0000473 ! testis +relationship: part_of NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000473 ! testis +[Term] +id: UBERON:0005213 +name: outer renal medulla interstitium +is_a: UBERON:0005211 ! renal medulla interstitium +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: part_of UBERON:0001293 ! outer medulla of kidney +relationship: part_of UBERON:0001293 ! outer medulla of kidney + +[Term] +id: UBERON:0005214 +name: inner renal medulla interstitium +is_a: UBERON:0005211 ! renal medulla interstitium +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: part_of UBERON:0001294 ! inner medulla of kidney +relationship: part_of UBERON:0001294 ! inner medulla of kidney + [Term] id: UBERON:0005215 name: kidney interstitium namespace: uberon def: "The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes." [DOI:10.1038/ki.1991.49, http://orcid.org/0000-0002-6601-2165, PMID:18575881] +subset: human_reference_atlas subset: pheno_slim synonym: "interstitial tissue of kidney" EXACT [] synonym: "kidney interstitium group" RELATED [EMAPA:28518] @@ -268069,8 +379150,13 @@ xref: NCIT:C33459 xref: SCTID:362210003 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005169 ! interstitial tissue +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: part_of UBERON:0002113 ! kidney +relationship: composed_primarily_of CL:1000692 ! kidney interstitial fibroblast +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney property_value: editor_note "See https://sourceforge.net/p/geneontology/ontology-requests/10941/" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000009 "The interstitium is necessarily involved in all intrarenal exchange processes since the reabsorption and secretion of fluid and solutes implicates a transit across the interstitial compartment." xsd:string property_value: UBPROP:0000010 "The fibroblasts in the interstitium provide the 'skeleton' of the tissue and maintain the three-dimensional architecture of the tissue." xsd:string @@ -268088,6 +379174,22 @@ intersection_of: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0005234 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! optic eminence ectoderm relationship: part_of UBERON:0005234 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! optic eminence ectoderm +[Term] +id: UBERON:0005217 +name: midbrain subarachnoid space +is_a: UBERON:0000315 ! subarachnoid space +intersection_of: UBERON:0000315 ! subarachnoid space +intersection_of: part_of UBERON:0001891 ! midbrain +relationship: part_of UBERON:0001891 ! midbrain + +[Term] +id: UBERON:0005218 +name: diencephalon subarachnoid space +is_a: UBERON:0000315 ! subarachnoid space +intersection_of: UBERON:0000315 ! subarachnoid space +intersection_of: part_of UBERON:0001894 ! diencephalon +relationship: part_of UBERON:0001894 ! diencephalon + [Term] id: UBERON:0005219 name: hindbrain subarachnoid space @@ -268097,10 +379199,98 @@ synonym: "subarachnoid space hindbrain" EXACT [VHOG:0001303] synonym: "subarachnoid space rhombencephalon" RELATED [VHOG:0001303] xref: EMAPA:18211 xref: VHOG:0001303 -is_a: UBERON:0000315 ! subarachnoid space +is_a: UBERON:0039175 ! subarachnoid space of brain +intersection_of: UBERON:0000315 ! subarachnoid space +intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain property_value: UBPROP:0000001 "Subarachnoid space that is part of the hindbrain. [Bgee_curator][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001303", ontology="VHOG", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005221 +name: liver right lobe parenchyma +namespace: uberon +def: "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." [OBOL:automatic] +synonym: "parenchyma of right lobe of liver" EXACT [FMA:71657] +xref: EHDAA2:0001010 +xref: EMAPA:18317 +xref: FMA:71657 +xref: VHOG:0000840 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001114 ! right lobe of liver +relationship: part_of UBERON:0001114 ! right lobe of liver + +[Term] +id: UBERON:0005222 +name: liver left lobe parenchyma +namespace: uberon +def: "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." [OBOL:automatic] +synonym: "parenchyma of left lobe of liver" EXACT [FMA:71658] +xref: EHDAA2:0001002 +xref: EMAPA:18310 +xref: FMA:71658 +xref: VHOG:0000839 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001115 ! left lobe of liver +relationship: part_of UBERON:0001115 ! left lobe of liver + +[Term] +id: UBERON:0005225 +name: upper leg epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod +relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm +relationship: part_of UBERON:0000376 ! hindlimb stylopod + +[Term] +id: UBERON:0005226 +name: pedal digit epithelium +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: develops_from UBERON:0003248 ! epithelium of footplate +relationship: part_of UBERON:0001466 ! pedal digit + +[Term] +id: UBERON:0005227 +name: manual digit epithelium +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: develops_from UBERON:0010332 ! epithelium of handplate +relationship: part_of UBERON:0002389 ! manual digit + +[Term] +id: UBERON:0005228 +name: upper arm epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003822 ! forelimb stylopod +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0003822 ! forelimb stylopod + +[Term] +id: UBERON:0005229 +name: lower leg epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: develops_from UBERON:0003371 ! pelvic appendage bud ectoderm +relationship: part_of UBERON:0003823 ! hindlimb zeugopod + +[Term] +id: UBERON:0005233 +name: medial-nasal process ectoderm +is_a: UBERON:0000924 ! ectoderm +is_a: UBERON:0014702 ! frontonasal process epithelium +intersection_of: UBERON:0000924 ! ectoderm +intersection_of: part_of UBERON:0004068 ! medial nasal prominence +relationship: part_of UBERON:0004068 ! medial nasal prominence + [Term] id: UBERON:0005234 name: optic eminence ectoderm @@ -268147,6 +379337,7 @@ xref: XAO:0000199 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001839 ! bony labyrinth property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray919.png xsd:anyURI property_value: UBPROP:0000001 "The vestibule is the central part of the osseous labyrinth, and is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals. [Wikipedia:Vestibule_of_the_ear][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001220", ontology="VHOG", source="http://bgee.unil.ch/"} @@ -268221,6 +379412,26 @@ intersection_of: part_of UBERON:0000930 ! stomodeum relationship: part_of UBERON:0000930 ! stomodeum property_value: editor_note "check this" xsd:string +[Term] +id: UBERON:0005251 +name: yolk sac cavity +namespace: uberon +def: "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." [OBOL:automatic] +synonym: "cavity of yolk sac" EXACT [FMA:63942] +synonym: "yolk sac lumen" EXACT [] +synonym: "yolk sac space" RELATED [FMA:63942] +xref: EMAPA:16055 +xref: FMA:63942 +xref: VHOG:0000843 +is_a: UBERON:0002553 ! anatomical cavity +is_a: UBERON:0007473 ! lumen of epithelial sac +is_a: UBERON:0012466 ! extraembryonic cavity +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0001040 ! yolk sac +relationship: luminal_space_of UBERON:0001040 ! yolk sac +property_value: UBPROP:0000008 "In mammals, the yolk sac cavity contains fluid rather than platelets" xsd:string {source="ISBN:0073040584"} +property_value: UBPROP:0000012 "in EHDAA2, there are separate primary and secondary yolk sac cavities" xsd:string {external_ontology="EHDAA2"} + [Term] id: UBERON:0005253 name: head mesenchyme @@ -268258,8 +379469,21 @@ xref: EHDAA2:0002132 xref: EMAPA:17501 xref: VHOG:0000506 is_a: UBERON:0003860 ! hindlimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod relationship: part_of UBERON:0000376 ! hindlimb stylopod +[Term] +id: UBERON:0005255 +name: pedal digit mesenchyme +is_a: UBERON:0003860 ! hindlimb mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010702 ! digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: develops_from UBERON:0003328 ! mesenchyme of footplate +relationship: part_of UBERON:0001466 ! pedal digit + [Term] id: UBERON:0005256 name: trunk mesenchyme @@ -268283,6 +379507,17 @@ intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0009142 {source="EHDAA2"} ! entire embryonic mesenchyme +[Term] +id: UBERON:0005257 +name: manual digit mesenchyme +is_a: UBERON:0003859 ! forelimb mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010702 ! digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: develops_from UBERON:0009523 ! mesenchyme of handplate +relationship: part_of UBERON:0002389 ! manual digit + [Term] id: UBERON:0005258 name: upper arm mesenchyme @@ -268292,6 +379527,8 @@ xref: EHDAA2:0002114 xref: EMAPA:17426 xref: VHOG:0000505 is_a: UBERON:0003859 ! forelimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003822 ! forelimb stylopod relationship: part_of UBERON:0003822 ! forelimb stylopod [Term] @@ -268303,6 +379540,8 @@ xref: EHDAA2:0001032 xref: EMAPA:17498 xref: VHOG:0000752 is_a: UBERON:0003860 ! hindlimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0003823 ! hindlimb zeugopod [Term] @@ -268318,7 +379557,11 @@ xref: EMAPA:28147 xref: MA:0002582 is_a: UBERON:0001637 ! artery is_a: UBERON:0003644 ! kidney arterial blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001225 ! cortex of kidney +relationship: contributes_to_morphology_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney +relationship: supplies UBERON:0001225 ! cortex of kidney [Term] id: UBERON:0005269 @@ -268332,18 +379575,34 @@ xref: EMAPA:28152 xref: MA:0002592 is_a: UBERON:0013126 ! vein of abdomen is_a: UBERON:0014401 ! renal venous blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001225 ! cortex of kidney +relationship: contributes_to_morphology_of UBERON:0001225 ! cortex of kidney +relationship: drains UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney +[Term] +id: UBERON:0005270 +name: renal cortex interstitium +is_a: UBERON:0005215 ! kidney interstitium +intersection_of: UBERON:0005169 ! interstitial tissue +intersection_of: part_of UBERON:0001225 ! cortex of kidney +relationship: has_part CL:0000057 ! fibroblast +relationship: has_part CL:0000451 ! dendritic cell +relationship: part_of UBERON:0001225 ! cortex of kidney + [Term] id: UBERON:0005272 name: peritubular capillary namespace: uberon def: "The tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure." [MGI:csmith, MP:0011321] +subset: human_reference_atlas subset: pheno_slim xref: EMAPA:36558 xref: MA:0002588 xref: Wikipedia:Peritubular_capillaries is_a: UBERON:0003527 ! kidney capillary +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005273 @@ -268380,6 +379639,8 @@ xref: FMA:38320 xref: FMA:60346 is_a: UBERON:0003533 ! manual digit skin is_a: UBERON:0005275 ! dorsal skin of digit +intersection_of: UBERON:0005275 ! dorsal skin of digit +intersection_of: part_of UBERON:0002389 ! manual digit property_value: UBPROP:0000012 "this class is explicitly the union of the two FMA classes" xsd:string {external_ontology="FMA"} [Term] @@ -268394,6 +379655,8 @@ xref: FMA:37868 xref: FMA:60523 is_a: UBERON:0003530 ! pedal digit skin is_a: UBERON:0005275 ! dorsal skin of digit +intersection_of: UBERON:0005275 ! dorsal skin of digit +intersection_of: part_of UBERON:0001466 ! pedal digit property_value: UBPROP:0000012 "this class is explicitly the union of the two FMA classes" xsd:string {external_ontology="FMA"} [Term] @@ -268412,8 +379675,8 @@ xref: EFO:0003650 xref: EHDAA2:0004362 xref: EV:0100306 xref: FMA:242675 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2497 xref: MBA:73 +xref: neuronames:2497 xref: TAO:0001261 xref: Wikipedia:Ventricular_system xref: ZFA:0001261 @@ -268447,17 +379710,48 @@ subset: pheno_slim subset: vertebrate_core synonym: "tela chorioidea" RELATED [FMA:242849] xref: FMA:242849 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1378 +xref: neuronames:1378 xref: TAO:0000447 xref: Wikipedia:Tela_chorioidea xref: ZFA:0000447 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 ! organ component layer +relationship: overlaps UBERON:0001886 ! choroid plexus +relationship: overlaps UBERON:0010743 ! meningeal cluster relationship: part_of UBERON:0005358 {source="FMA"} ! ventricle of nervous system property_value: UBPROP:0000001 "Portion of tissue that is part of the primitive meninx which forms a fold, roofing a ventricle of the brain and supporting the choroid plexus[ZFA:0000447]." xsd:string {source="ZFA:0000447"} property_value: UBPROP:0000010 "Vascularized tela choroidea is choroid plexus." xsd:string property_value: UBPROP:0000012 "Note that the structure in ZFA may be different" xsd:string {external_ontology="ZFA"} +[Term] +id: UBERON:0005287 +name: tela choroidea of fourth ventricle +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005283 ! tela choroidea +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0005283 ! tela choroidea +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002422 ! fourth ventricle + +[Term] +id: UBERON:0005288 +name: tela choroidea of third ventricle +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005283 ! tela choroidea +intersection_of: UBERON:0005283 ! tela choroidea +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002286 ! third ventricle + +[Term] +id: UBERON:0005289 +name: tela choroidea of telencephalic ventricle +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005283 ! tela choroidea +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0005283 ! tela choroidea +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle +relationship: part_of UBERON:0002285 ! telencephalic ventricle + [Term] id: UBERON:0005290 name: myelencephalon @@ -268476,6 +379770,7 @@ xref: EMAPA:17082 xref: HBA:9512 xref: http://en.wikipedia.org/wiki/Myelencephalon xref: MA:0000205 +xref: MESH:D054024 xref: VHOG:0000456 xref: Wikipedia:Myelencephalon is_a: UBERON:0004733 ! segmental subdivision of hindbrain @@ -268613,6 +379908,8 @@ xref: VHOG:0001339 xref: Wikipedia:Cortical_cords is_a: UBERON:0004911 ! epithelium of female gonad is_a: UBERON:0005295 ! sex cord +intersection_of: UBERON:0005295 ! sex cord +intersection_of: part_of UBERON:0000992 ! ovary relationship: develops_from UBERON:0010141 ! primitive sex cord of indifferent gonad property_value: editor_note "TODO check secondary vs cortical vs ovary" xsd:string @@ -268633,9 +379930,31 @@ xref: VHOG:0001321 xref: Wikipedia:Testis_cords is_a: UBERON:0004910 ! epithelium of male gonad is_a: UBERON:0005295 ! sex cord +intersection_of: UBERON:0005295 ! sex cord +intersection_of: part_of UBERON:0000473 ! testis relationship: immediate_transformation_of UBERON:0010141 {source="Bgee:AN"} ! primitive sex cord of indifferent gonad property_value: editor_note "TODO - check primary vs testis" xsd:string +[Term] +id: UBERON:0005298 +name: skin of clitoris +is_a: UBERON:0000014 ! zone of skin +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: part_of UBERON:0002411 ! clitoris + +[Term] +id: UBERON:0005299 +name: prepuce of clitoris +is_a: UBERON:0011374 ! prepuce +intersection_of: UBERON:0011374 ! prepuce +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: adjacent_to UBERON:0006653 ! glans clitoris +relationship: part_of UBERON:0002411 ! clitoris +relationship: transformation_of UBERON:0035006 ! preputial swelling of female + [Term] id: UBERON:0005301 name: male preputial gland @@ -268682,6 +380001,7 @@ id: UBERON:0005304 name: submucous nerve plexus namespace: uberon def: "The gangliated plexus of unmyelinated nerve fibers that ramify the stomach and intestinal submucosa." [ISBN:0-683-40008-8, MP:0010800] +subset: human_reference_atlas subset: pheno_slim synonym: "Henle's plexus" RELATED [MA:0001149] synonym: "Meissner's plexus" RELATED [HP:0002251, MA:0001149] @@ -268697,6 +380017,7 @@ xref: SCTID:322349001 xref: UMLS:C0038564 {source="ncithesaurus:Submucous_Nerve_Plexus"} xref: Wikipedia:Meissner's_plexus is_a: UBERON:0000429 ! enteric plexus +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "in FMA this is part of the esophagus, duodenum and intestine; this violates part-disjointness axioms in uberon" xsd:string {external_ontology="FMA"} [Term] @@ -268721,8 +380042,27 @@ xref: UMLS:C0229577 {source="ncithesaurus:Thyroid_Gland_Follicle"} xref: ZFA:0001072 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland +[Term] +id: UBERON:0005309 +name: pronephric nephron +is_a: UBERON:0001285 ! nephron +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001285 ! nephron +intersection_of: part_of UBERON:0002120 ! pronephros +relationship: part_of UBERON:0002120 ! pronephros + +[Term] +id: UBERON:0005310 +name: pronephric nephron tubule +is_a: UBERON:0001231 ! nephron tubule +is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0001231 ! nephron tubule +intersection_of: part_of UBERON:0005309 ! pronephric nephron +relationship: part_of UBERON:0005309 ! pronephric nephron + [Term] id: UBERON:0005311 name: mammary placode @@ -268775,6 +380115,15 @@ intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 ! pulmonary artery +[Term] +id: UBERON:0005319 +name: mesonephric collecting duct +is_a: UBERON:0001232 ! collecting duct of renal tubule +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001232 ! collecting duct of renal tubule +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0005322 ! mesonephric nephron + [Term] id: UBERON:0005321 name: mesonephric smooth muscle tissue @@ -268785,6 +380134,16 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros +[Term] +id: UBERON:0005322 +name: mesonephric nephron +is_a: UBERON:0001285 ! nephron +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001285 ! nephron +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: develops_from UBERON:0005323 ! mesonephric mesenchyme +relationship: part_of UBERON:0000080 ! mesonephros + [Term] id: UBERON:0005323 name: mesonephric mesenchyme @@ -268801,6 +380160,66 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros +[Term] +id: UBERON:0005325 +name: mesonephric glomerulus +is_a: UBERON:0000074 ! renal glomerulus +intersection_of: UBERON:0000074 ! renal glomerulus +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0000080 ! mesonephros + +[Term] +id: UBERON:0005326 +name: mesonephric glomerulus vasculature +is_a: UBERON:0004190 ! renal glomerulus vasculature +intersection_of: UBERON:0004190 ! renal glomerulus vasculature +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0005325 ! mesonephric glomerulus + +[Term] +id: UBERON:0005327 +name: mesonephric glomerular epithelium +is_a: UBERON:0004188 ! glomerular epithelium +is_a: UBERON:0005330 ! mesonephric nephron epithelium +intersection_of: UBERON:0004188 ! glomerular epithelium +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0005325 ! mesonephric glomerulus + +[Term] +id: UBERON:0005328 +name: mesonephric comma-shaped body +is_a: UBERON:0004198 ! comma-shaped body +intersection_of: UBERON:0004198 ! comma-shaped body +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0000080 ! mesonephros + +[Term] +id: UBERON:0005330 +name: mesonephric nephron epithelium +is_a: UBERON:0004211 ! nephron epithelium +is_a: UBERON:0005103 ! mesonephric epithelium +intersection_of: UBERON:0004211 ! nephron epithelium +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0005322 ! mesonephric nephron + +[Term] +id: UBERON:0005331 +name: mesonephric renal vesicle +is_a: UBERON:0004209 ! renal vesicle +is_a: UBERON:0005103 ! mesonephric epithelium +intersection_of: UBERON:0004209 ! renal vesicle +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: develops_from UBERON:0010534 ! primitive mesonephric nephron +relationship: has_potential_to_develop_into UBERON:0005330 ! mesonephric nephron epithelium + +[Term] +id: UBERON:0005332 +name: mesonephric S-shaped body +is_a: UBERON:0004199 ! S-shaped body +intersection_of: UBERON:0004199 ! S-shaped body +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0000080 ! mesonephros + [Term] id: UBERON:0005333 name: mammary bud @@ -268814,6 +380233,8 @@ synonym: "milk bud" RELATED [] xref: EMAPA:35536 is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0005153 ! epithelial bud +intersection_of: transformation_of UBERON:0005311 ! mammary placode relationship: transformation_of UBERON:0005311 ! mammary placode property_value: UBPROP:0000011 "produced along the length of the embryonic mammary ridge these buds represent the future locations of the mammary glands. Invagination of ectoderm at each bud leads to the development of epithelial diverticula, later maturing as lactiferous ducts" xsd:string {source="http://medical-dictionary.thefreedictionary.com/mammary+bud"} @@ -268883,6 +380304,7 @@ synonym: "dorsal commissure" EXACT [MP:0008219] xref: EMAPA:37844 {source="MA:th"} xref: NLX:147892 is_a: UBERON:0019294 ! commissure of telencephalon +relationship: connects UBERON:0000203 ! pallium [Term] id: UBERON:0005341 @@ -268923,8 +380345,8 @@ synonym: "neocortex cortical plate" EXACT [] xref: BAMS:CTXpl xref: DHBA:10515 xref: EMAPA:32711 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2702 xref: MBA:695 +xref: neuronames:2702 xref: PBA:294021914 is_a: UBERON:0014950 ! layer of developing cerebral cortex relationship: has_potential_to_develop_into UBERON:0001950 {source="NCBIBook:NBK10047"} ! neocortex @@ -268969,7 +380391,7 @@ synonym: "neuraxis folium" RELATED [FMA:83889] synonym: "vermic lobule VIIA" EXACT [NLXANAT:20081231] xref: EMAPA:37823 {source="MA:th"} xref: FMA:83889 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=675 +xref: neuronames:675 xref: NLXANAT:20081231 is_a: UBERON:0004081 {source="NIF"} ! cerebellum vermis lobule VII @@ -268993,7 +380415,7 @@ xref: EMAPA:37824 {source="MA:th"} xref: FMA:83890 xref: HBA:12940 xref: HBA:4708 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=676 +xref: neuronames:676 xref: NLXANAT:20081232 is_a: UBERON:0004081 {source="NIF"} ! cerebellum vermis lobule VII @@ -269004,8 +380426,8 @@ namespace: uberon subset: pheno_slim xref: BAMS:COPY xref: EMAPA:37400 {source="MA:th"} -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1894 xref: MBA:1033 +xref: neuronames:1894 is_a: UBERON:0004003 ! cerebellum hemisphere lobule property_value: RO:0002161 NCBITaxon:9606 {source="MP"} property_value: RO:0002171 UBERON:0001063 {source="ABA"} @@ -269032,8 +380454,8 @@ xref: BAMS:AN xref: BAMS:An xref: EMAPA:37397 {source="MA:th"} xref: FMA:72257 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=666 xref: MBA:1017 +xref: neuronames:666 is_a: UBERON:0004003 ! cerebellum hemisphere lobule property_value: RO:0002171 UBERON:0001063 {source="ABA"} property_value: RO:0002171 UBERON:0005347 {source="ABA"} @@ -269067,8 +380489,8 @@ xref: DMBA:16943 xref: EMAPA:37403 {source="MA:th"} xref: FMA:72523 xref: HBA:12942 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=669 xref: MBA:1025 +xref: neuronames:669 xref: NLXANAT:20081210 is_a: UBERON:0004070 ! cerebellum vermis lobule relationship: part_of UBERON:0004009 ! cerebellum posterior vermis @@ -269108,8 +380530,8 @@ xref: BAMS:SL xref: DMBA:16940 xref: EMAPA:37401 {source="MA:th"} xref: FMA:72522 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=665 xref: MBA:1007 +xref: neuronames:665 xref: NLXANAT:20081206 is_a: UBERON:0004003 ! cerebellum hemisphere lobule is_a: UBERON:0014648 ! hemisphere part of cerebellar posterior lobe @@ -269139,8 +380561,8 @@ xref: DMBA:16945 xref: EMAPA:37402 {source="MA:th"} xref: FMA:278790 xref: FMA:83885 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=672 xref: MBA:1041 +xref: neuronames:672 xref: NLXANAT:20081212 xref: SCTID:314174005 xref: SCTID:51969002 @@ -269172,14 +380594,17 @@ xref: UMLS:C0037855 {source="ncithesaurus:Spermatic_Cord"} xref: Wikipedia:Spermatic_cord is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034921 ! multi organ part structure +relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia +relationship: has_part UBERON:0001000 ! vas deferens relationship: part_of UBERON:0004054 ! internal male genitalia -property_value: depicted:by Male:anatomy.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png xsd:anyURI [Term] id: UBERON:0005353 name: spleen perifollicular zone namespace: uberon def: "The compartment located between the marginal zone and the red pulp harboring scattered B and T lymphocytes[MP]." [MP:0010245] +subset: human_reference_atlas subset: pheno_slim is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010000 ! multicellular anatomical structure @@ -269239,9 +380664,9 @@ xref: AAO:0011094 xref: EHDAA2:0001588 xref: EMAPA:16725 xref: FMA:302929 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1516 xref: NCIT:C34281 xref: NCIT:C54098 +xref: neuronames:1516 xref: SCTID:362583008 xref: SCTID:61127000 xref: UMLS:C0229548 {source="ncithesaurus:Rathke_s_Pouch"} @@ -269273,6 +380698,9 @@ xref: FMA:242837 xref: MA:0000809 xref: MESH:D004805 is_a: UBERON:0004670 ! ependyma +intersection_of: UBERON:0004670 ! ependyma +intersection_of: part_of UBERON:0004086 ! brain ventricle +relationship: contributes_to_morphology_of UBERON:0003947 ! brain ventricle/choroid plexus relationship: part_of UBERON:0004086 ! brain ventricle property_value: UBPROP:0000012 "in FMA this is treated as part of the ependyma, but here we treat ependyma as a portion" xsd:string {external_ontology="FMA"} @@ -269303,6 +380731,9 @@ xref: FMA:242839 xref: MA:0001125 xref: SCTID:369278000 is_a: UBERON:0004670 ! ependyma +intersection_of: UBERON:0004670 ! ependyma +intersection_of: part_of UBERON:0002240 ! spinal cord +relationship: contributes_to_morphology_of UBERON:0002240 ! spinal cord relationship: develops_from UBERON:0034710 ! spinal cord ventricular layer relationship: part_of UBERON:0002291 ! central canal of spinal cord property_value: UBPROP:0000012 "in FMA this is treated as part of the ependyma, but here we treat ependyma as a portion" xsd:string {external_ontology="FMA"} @@ -269475,10 +380906,10 @@ xref: EFO:0000108 xref: EHDAA2_RETIRED:0001294 xref: EHDAA:5480 xref: EMAPA:17778 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2078 xref: MA:0002413 xref: MIAA:0000116 xref: NCIT:C33204 +xref: neuronames:2078 xref: UMLS:C0178780 {source="ncithesaurus:Olfactory_Lobe"} xref: VHOG:0000833 is_a: UBERON:0016526 ! lobe of cerebral hemisphere @@ -269494,6 +380925,9 @@ synonym: "hippocampus granular layer" RELATED [] xref: EMAPA:35406 xref: MA:0000954 is_a: UBERON:0002305 ! layer of hippocampus +intersection_of: UBERON:0002305 ! layer of hippocampus +intersection_of: composed_primarily_of CL:0001033 ! hippocampal granule cell +relationship: composed_primarily_of CL:0001033 ! hippocampal granule cell property_value: editor_note "TODO - check this. The granule layer is typically in the dentate gyrus, under some definitions of hippocampus, the DG is included, thus making this layer a hippocampal layer" xsd:string [Term] @@ -269504,11 +380938,11 @@ def: "The most superficial stratum in the hippocampus. Here the perforant path f subset: pheno_slim synonym: "hippocampal molecular layer" EXACT [BIRNLEX:1211] synonym: "hippocampus stratum moleculare" EXACT [] -synonym: "molecular layer of hippocampus" EXACT [BIRNLEX:1211, http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1742] +synonym: "molecular layer of hippocampus" EXACT [BIRNLEX:1211, neuronames:1742] xref: BIRNLEX:1211 xref: EMAPA:35408 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1742 xref: MA:0000955 +xref: neuronames:1742 is_a: UBERON:0002305 ! layer of hippocampus relationship: part_of UBERON:0007640 ! hippocampus stratum lacunosum moleculare @@ -269543,8 +380977,8 @@ xref: BAMS:Or xref: BIRNLEX:4113 xref: EMAPA:35412 xref: FMA:83893 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 {source="BIRNLEX:4113"} xref: MA:0000958 +xref: neuronames:157 {source="BIRNLEX:4113"} is_a: UBERON:0002305 ! layer of hippocampus [Term] @@ -269561,8 +380995,8 @@ xref: BAMS:Rad xref: BIRNLEX:1298 xref: EMAPA:35413 xref: FMA:83894 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=158 {source="BIRNLEX:1298"} xref: MA:0000959 +xref: neuronames:158 {source="BIRNLEX:1298"} is_a: UBERON:0002305 ! layer of hippocampus property_value: UBPROP:0000010 "contains septal and commissural fibers. It also contains Schaffer collateral fibers, which are the projection forward from CA3 to CA1. Some interneurons that can be found in more superficial layers can also be found here, including basket cells, bistratified cells, and radial trilaminar cells" xsd:string @@ -269580,10 +381014,10 @@ synonym: "posterior column" EXACT [Wikipedia:Posterior_column] synonym: "spinal cord posterior column" EXACT [] xref: BAMS:dc xref: EV:0100317 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2681 xref: MA:0002749 xref: MBA:514 xref: NCIT:C33355 +xref: neuronames:2681 xref: UMLS:C0458459 {source="ncithesaurus:Posterior_Column"} xref: VHOG:0001623 xref: Wikipedia:Posterior_column @@ -269602,8 +381036,8 @@ subset: pheno_slim synonym: "lateral column" RELATED [] synonym: "lateral columns" RELATED PLURAL [ZFA:0000531] xref: EV:0100322 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1673 xref: MA:0002750 +xref: neuronames:1673 xref: TAO:0000531 xref: VHOG:0001621 xref: ZFA:0000531 @@ -269621,10 +381055,11 @@ synonym: "anterior column" EXACT [] synonym: "spinal cord anterior column" EXACT [] synonym: "ventral column" EXACT [] xref: EV:0100326 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=269 xref: MA:0002751 +xref: neuronames:269 xref: VHOG:0001622 is_a: UBERON:0016550 ! spinal cord column +relationship: contributes_to_morphology_of UBERON:0002318 ! white matter of spinal cord relationship: part_of UBERON:0002180 ! ventral funiculus of spinal cord property_value: UBPROP:0000001 "The ventral ridge of gray matter in each half of the spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001622", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/anterior+column+of+spinal+cord"} property_value: UBPROP:0000012 "in MA, this is a subclass of white matter, but in WP/Gray's, the anterior column is a synonym of the grey matter section. is this the same as funiculus? See lateral column." xsd:string {external_ontology="MA"} @@ -269663,9 +381098,9 @@ xref: BAMS:Gl xref: BTO:0001317 xref: DHBA:11327 xref: EMAPA:35608 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2710 xref: MA:0000970 xref: MBA:212 +xref: neuronames:2710 xref: NLXANAT:1005007 xref: TAO:0000357 xref: ZFA:0000357 @@ -269688,9 +381123,9 @@ xref: BAMS:MOBgr xref: BTO:0001327 xref: DMBA:15909 xref: EMAPA:35609 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2714 xref: MA:0000971 xref: MBA:220 +xref: neuronames:2714 xref: NLXANAT:20090404 is_a: UBERON:0004001 ! olfactory bulb layer @@ -269709,9 +381144,9 @@ xref: BTO:0001320 xref: DHBA:11330 xref: DMBA:15910 xref: EMAPA:35610 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2713 xref: MA:0000972 xref: MBA:228 +xref: neuronames:2713 is_a: UBERON:0009950 ! olfactory bulb plexiform layer [Term] @@ -269742,10 +381177,15 @@ xref: BIRNLEX:4129 xref: DMBA:16122 xref: EMAPA:35276 xref: FMA:83146 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2122 xref: MA:0000946 xref: MBA:632 +xref: neuronames:2122 is_a: UBERON:0002304 ! layer of dentate gyrus +intersection_of: UBERON:0002304 ! layer of dentate gyrus +intersection_of: immediately_deep_to UBERON:0004679 ! dentate gyrus molecular layer +relationship: composed_primarily_of CL:0000120 ! granule cell +relationship: immediately_deep_to UBERON:0004679 ! dentate gyrus molecular layer +relationship: overlaps CL:0000118 ! basket cell [Term] id: UBERON:0005382 @@ -269765,9 +381205,9 @@ xref: BAMS:StrD xref: BTO:0004701 xref: EMAPA:36575 xref: FMA:77620 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2340 xref: MA:0002971 xref: MBA:485 +xref: neuronames:2340 xref: NLXANAT:1010001 xref: PBA:10081 xref: Wikipedia:Dorsal_striatum @@ -269777,7 +381217,7 @@ property_value: UBPROP:0000001 "According to BrainInfo it is a part of the basal property_value: UBPROP:0000001 "According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (putamen and the globus pallidus) and the caudate nucleus" xsd:string {source="Wikipedia:Dorsal_striatum"} property_value: UBPROP:0000001 "It may also refer to both the basal ganglia and the internal capsule collectively." xsd:string {source="Wikipedia:Dorsal_striatum"} property_value: UBPROP:0000001 "It may also refer to the putamen and caudate collectively." xsd:string {source="Wikipedia:Dorsal_striatum"} -property_value: UBPROP:0000001 "The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance." xsd:string {source="http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2340"} +property_value: UBPROP:0000001 "The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance." xsd:string {source="neuronames:2340"} [Term] id: UBERON:0005383 @@ -269831,6 +381271,11 @@ xref: VHOG:0000501 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004814 ! upper respiratory tract epithelium is_a: UBERON:0019306 ! nose epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa +relationship: bounding_layer_of UBERON:0015788 ! olfactory apparatus chamber +relationship: contributes_to_morphology_of UBERON:0000004 ! nose +relationship: contributes_to_morphology_of UBERON:0004785 ! respiratory system mucosa relationship: part_of UBERON:0001826 ! nasal cavity mucosa property_value: editor_note "this class may in future be split into the embryonic precursor of the oronasal membrane and the structure that is part of the mucosa in the developed organism" xsd:string @@ -269855,6 +381300,10 @@ xref: NCIT:C33205 xref: UMLS:C0028937 {source="ncithesaurus:Olfactory_Mucosa"} xref: Wikipedia:Olfactory_mucosa is_a: UBERON:0001826 ! nasal cavity mucosa +intersection_of: UBERON:0001826 ! nasal cavity mucosa +intersection_of: has_part UBERON:0001997 ! olfactory epithelium +intersection_of: part_of UBERON:0005725 ! olfactory system +relationship: has_part UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0005725 ! olfactory system property_value: UBPROP:0000001 "The olfactory mucosa is located in the upper region of the nasal cavity and is made up of the olfactory epithelium and the underlying lamina propria, connective tissue containing fibroblasts, blood vessels, Bowman's glands and bundles of fine axons from the olfactory neurons. The mucus protects the olfactory epithelium and allows odors to dissolve so that they can be detected by olfactory receptor neurons. Electron microscopy studies show that Bowman's glands contain cells with large secretory vesicles. The exact composition of the secretions from Bowman's glands is unclear, but there is evidence that Bowman's glands do not produce odorant binding protein[WP][Wikipedia:Olfactory_mucosa]." xsd:string {source="Wikipedia:Olfactory_mucosa"} @@ -269865,7 +381314,6 @@ namespace: uberon def: "An array of photoreceptors and any supporting cells found in an eye." [https://orcid.org/0000-0002-6601-2165] synonym: "light-sensitive tissue" EXACT [] xref: FBbt:00004200 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -269909,9 +381357,9 @@ synonym: "neocortex layer II" EXACT [NLXANAT:090808] xref: ABA:CTX2 xref: EMAPA:35256 xref: FMA:77804 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2446 xref: MA:0000898 xref: NCIT:C32557 +xref: neuronames:2446 xref: NLXANAT:090808 xref: PBA:294021800 xref: UMLS:C1517039 {source="ncithesaurus:External_Granular_Layer"} @@ -269957,6 +381405,15 @@ is_a: UBERON:0004573 {source="FMA"} ! systemic artery property_value: editor_note "This is a generic grouping class that is the superclass of the trunks/branches of the common carotid artery. Note that AOs vary widely in how they divide up and generalize arteries" xsd:string property_value: UBPROP:0000001 "Artery originating at the junction of the first two aortic arches and supplying the anterior brain. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000097", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0005397 +name: brain arachnoid mater +is_a: UBERON:0002362 ! arachnoid mater +is_a: UBERON:0003547 ! brain meninx +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: surrounds UBERON:0000955 ! brain +relationship: surrounds UBERON:0000955 ! brain + [Term] id: UBERON:0005398 name: female reproductive gland @@ -269983,8 +381440,18 @@ xref: BTO:0000080 xref: EMAPA:19285 xref: MA:0000399 is_a: UBERON:0003937 ! reproductive gland +intersection_of: UBERON:0003937 ! reproductive gland +intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system +[Term] +id: UBERON:0005400 +name: telencephalon arachnoid mater +is_a: UBERON:0003289 ! meninx of telencephalon +is_a: UBERON:0003556 ! forebrain arachnoid mater +intersection_of: UBERON:0002362 ! arachnoid mater +intersection_of: part_of UBERON:0001893 ! telencephalon + [Term] id: UBERON:0005401 name: cerebral hemisphere gray matter @@ -270045,15 +381512,16 @@ xref: DMBA:15858 xref: EFO:0001936 xref: EMAPA:36576 xref: FMA:77614 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2341 xref: MA:0002972 xref: MBA:493 +xref: MESH:D066328 +xref: neuronames:2341 xref: NLX:57107 xref: PBA:10091 xref: Wikipedia:Ventral_striatum is_a: UBERON:0011300 ! gray matter of telencephalon relationship: part_of UBERON:0002435 {source="MA"} ! striatum -property_value: UBPROP:0000001 "The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 )." xsd:string {source="http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2341"} +property_value: UBPROP:0000001 "The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 )." xsd:string {source="neuronames:2341"} [Term] id: UBERON:0005404 @@ -270080,6 +381548,9 @@ xref: EHDAA:10101 xref: FMA:77591 xref: MA:0002982 is_a: UBERON:0001808 ! parasympathetic ganglion +intersection_of: UBERON:0000045 ! ganglion +intersection_of: extends_fibers_into UBERON:0001832 ! sublingual gland +relationship: extends_fibers_into UBERON:0001832 ! sublingual gland [Term] id: UBERON:0005408 @@ -270092,8 +381563,9 @@ synonym: "circumventricular organ of neuraxis" EXACT [FMA:84081] synonym: "CVO" EXACT ABBREVIATION [NLXANAT:20090312] xref: EMAPA:35243 xref: FMA:84081 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1242 xref: MA:0002942 +xref: MESH:D066280 +xref: neuronames:1242 xref: NLXANAT:20090312 xref: Wikipedia:Circumventricular_organs is_a: UBERON:0002616 ! regional part of brain @@ -270128,6 +381600,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0012240 xref: http://www.snomedbrowser.com/Codes/Details/373871007 xref: MA:0000323 xref: MESH:A03.492 +xref: MESH:D041981 xref: NCIT:C12378 xref: SCTID:373871007 xref: UMLS:C0012240 {source="ncithesaurus:Gastrointestinal_System"} @@ -270159,6 +381632,8 @@ xref: TAO:0001500 xref: ZFA:0001500 is_a: UBERON:0003932 ! cartilage element of chondrocranium is_a: UBERON:0004637 ! otic capsule +intersection_of: UBERON:0004637 ! otic capsule +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010349 {source="EHDAA2"} ! otic capsule pre-cartilage condensation property_value: UBPROP:0000001 "Bilaterally paired cartilage encasing the semicircular canals of the inner ear.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001500", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000002 "relationship type change: overlaps neurocranium (TAO:0001580) CHANGED TO: develops_from neurocranium (UBERON:0001703)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001500", ontology="TAO"} @@ -270178,6 +381653,8 @@ xref: MA:0000252 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0004637 ! otic capsule is_a: UBERON:0011164 ! neurocranium bone +intersection_of: UBERON:0004637 ! otic capsule +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0005410 ! cartilaginous otic capsule relationship: part_of UBERON:0001694 {source="EHDAA2"} ! petrous part of temporal bone property_value: UBPROP:0000008 "In elasmobranchs, the otic capsule remains cartilaginous in the adult; in the embryos of higher vertebrates, it is cartilaginous at first but later becomes bony (at approximately 23 weeks in humans)" xsd:string @@ -270209,6 +381686,8 @@ xref: XAO:0000474 xref: ZFA:0001284 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006846 {source="ZFA"} ! surface groove +disjoint_from: UBERON:0005745 ! optic foramen +relationship: located_in UBERON:0003098 ! optic stalk relationship: part_of UBERON:0016855 {source="cjm"} ! ventral part of optic cup property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/98/Gray865.png xsd:anyURI property_value: UBPROP:0000001 "A break in the continuity of the optic cup where the two sides of the cup meet.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011026", ontology="AAO", source="ISBN:0815318960"} @@ -270223,9 +381702,9 @@ subset: pheno_slim xref: BAMS:sc xref: DHBA:12749 xref: GAID:733 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1978 xref: MBA:85 xref: MESH:D020824 +xref: neuronames:1978 xref: NLX:60355 xref: NLXANAT:1005036 xref: Wikipedia:Spinocerebellar_tract @@ -270385,8 +381864,10 @@ intersection_of: part_of UBERON:0005419 ! pectoral appendage bud relationship: develops_from UBERON:0003372 {source="EHDAA2"} ! pectoral appendage bud ectoderm relationship: part_of UBERON:0005419 ! pectoral appendage bud property_value: UBPROP:0000001 "An ectodermal thickening at the end of the forelimb bud in the developing embryo. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001064", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge"} +property_value: UBPROP:0000001 "An ectodermal thickening at the end of the forelimb bud in the developing embryo. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001064", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge"} property_value: UBPROP:0000001 "Apical ectodermal ridge that is part of the pectoral fin bud.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000085", ontology="TAO", source="ZFIN:curator"} property_value: UBPROP:0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001064", ontology="VHOG", source="http://bgee.unil.ch/", source="https://doi.org/10.1111/j.1440-169X.2007.00942.x"} +property_value: UBPROP:0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001064", ontology="VHOG", source="DOI:10.1111/j.1440-169X.2007.00942.x", source="http://bgee.unil.ch/"} [Term] id: UBERON:0005422 @@ -270413,8 +381894,10 @@ intersection_of: part_of UBERON:0005420 ! pelvic appendage bud relationship: develops_from UBERON:0003371 {source="EHDAA2"} ! pelvic appendage bud ectoderm relationship: part_of UBERON:0005420 ! pelvic appendage bud property_value: UBPROP:0000001 "An ectodermal thickening at the end of the hindlimb bud in the developing embryo. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001066", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge"} +property_value: UBPROP:0000001 "An ectodermal thickening at the end of the hindlimb bud in the developing embryo. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001066", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/apical+ectodermal+ridge"} property_value: UBPROP:0000001 "Apical ectodermal ridge that is part of the pelvic fin bud.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001385", ontology="TAO", source="ZIFIN:curator"} property_value: UBPROP:0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001066", ontology="VHOG", source="http://bgee.unil.ch/", source="https://doi.org/10.1111/j.1440-169X.2007.00942.x"} +property_value: UBPROP:0000003 "Pectoral and pelvic fins are homologous to the tetrapod fore and hindlimb, respectively. (...) The zebrafish AER [apical ectodermal ridge] is an apical ectodermal thickening at the distal tip of the fin bud and consists of wedge-shaped cells of the basal stratum. The AER is observed only transiently, and from 36 hpf onwards the cells of this region form the apical fold (AF), which consists of a dorsal and a ventral layer of cylindrically-shaped ectodermal cells extending from the anterior to the posterior fin margin. Despite the change in shape, the AF still carries out the same functions as the AER. Indeed, although the AER receives its name from its characteristic shape, being composed of a pseudostratified ectoderm in the chicken and a polystratified ectoderm in the mouse, this independence of AER morphology from its function is also observed in tetrapods. The AF also expresses similar molecular markers to the tetrapod AER, suggesting that it fulfills similar functions in the fin as the AER does in tetrapod limbs.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001066", ontology="VHOG", source="DOI:10.1111/j.1440-169X.2007.00942.x", source="http://bgee.unil.ch/"} [Term] id: UBERON:0005423 @@ -270429,7 +381912,6 @@ xref: EHDAA2:0003125 xref: FBbt:00007006 xref: FMA:292313 xref: MIAA:0000019 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000465 ! material anatomical entity relationship: capable_of GO:0032502 ! developmental process @@ -270455,6 +381937,9 @@ xref: VHOG:0000492 xref: ZFA:0000064 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye +intersection_of: UBERON:0006598 ! presumptive structure +intersection_of: has_potential_to_develop_into UBERON:0001782 ! pigmented layer of retina +relationship: has_potential_to_develop_into UBERON:0001782 ! pigmented layer of retina relationship: part_of UBERON:0003072 ! optic cup property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000492", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"} @@ -270588,11 +382073,33 @@ is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: only_in_taxon NCBITaxon:8287 ! Sarcopterygii relationship: part_of UBERON:0000974 ! neck +[Term] +id: UBERON:0005436 +name: common hepatic artery +namespace: uberon +def: "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:." [Wikipedia:Common_hepatic_artery] +subset: human_reference_atlas +synonym: "arteria hepatica communis" RELATED LATIN [Wikipedia:Common_hepatic_artery] +synonym: "common hepatic" RELATED [Wikipedia:Common_hepatic_artery] +xref: EHDAA2:0000308 +xref: EHDAA:8570 +xref: EMAPA:37206 {source="MA:th"} +xref: FMA:14771 +xref: galen:CommonHepaticArtery +xref: MA:0003094 +xref: SCTID:244263001 +xref: Wikipedia:Common_hepatic_artery +is_a: UBERON:0004573 ! systemic artery +relationship: branching_part_of UBERON:0001640 ! celiac artery +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0005438 name: coronary sinus namespace: uberon def: "The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice." [ISBN:0-683-40008-8, MP:0010436] +subset: human_reference_atlas subset: pheno_slim synonym: "sinus coronarius" EXACT [] synonym: "sinus coronarius" RELATED LATIN [Wikipedia:Coronary_sinus] @@ -270600,6 +382107,7 @@ xref: EHDAA2:0000320 xref: EHDAA:9884 xref: EMAPA:37836 {source="MA:th"} xref: FMA:4706 +xref: MESH:D054326 xref: NCIT:C32378 xref: SCTID:244386006 xref: UMLS:C0456944 {source="ncithesaurus:Coronary_Sinus"} @@ -270608,6 +382116,7 @@ is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0003920 ! venous blood vessel relationship: part_of UBERON:0004581 ! systemic venous system property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray491.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "The sinus, before entering the auricle, is considerably dilated - nearly to the size of the end of the little finger. Its wall is partly muscular, and at its junction with the great coronary vein is somewhat constricted and furnished with a valve consisting of two unequal segments" xsd:string {source="WP"} [Term] @@ -270664,8 +382173,31 @@ xref: FMA:24993 xref: SCTID:362887000 is_a: UBERON:0008784 ! lower limb segment is_a: UBERON:0012139 ! segment of autopod +intersection_of: UBERON:0012139 ! segment of autopod +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0002387 ! pes +[Term] +id: UBERON:0005446 +name: foramen rotundum +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: conduit_for UBERON:0000377 ! maxillary nerve +intersection_of: part_of UBERON:0001677 ! sphenoid bone +relationship: conduit_for UBERON:0000377 ! maxillary nerve +relationship: part_of UBERON:0001677 ! sphenoid bone + +[Term] +id: UBERON:0005448 +name: greater omentum +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0003688 ! omentum +relationship: attaches_to UBERON:0001164 ! greater curvature of stomach +relationship: develops_from UBERON:0002296 ! dorsal mesentery +relationship: develops_from UBERON:0005602 ! dorsal mesogastrium +relationship: located_in UBERON:0003887 ! intraembryonic coelom + [Term] id: UBERON:0005449 name: greater sac @@ -270700,6 +382232,8 @@ xref: FMA:24945 xref: SCTID:127950000 is_a: UBERON:0008785 ! upper limb segment is_a: UBERON:0012139 ! segment of autopod +intersection_of: UBERON:0012139 ! segment of autopod +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0002398 ! manus [Term] @@ -270707,6 +382241,7 @@ id: UBERON:0005452 name: hepatic cord namespace: uberon def: "A three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids." [MGI:anna] +subset: human_reference_atlas subset: pheno_slim synonym: "hepatic lamina" EXACT [FMA:14655] synonym: "hepatic laminae" EXACT PLURAL [MP:MP] @@ -270718,6 +382253,7 @@ xref: FMA:14655 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004923 ! organ component layer relationship: part_of UBERON:0001172 ! hepatic acinus +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005455 @@ -270749,6 +382285,7 @@ xref: EHDAA2:0000893 xref: EHDAA:10631 xref: EMAPA:18713 xref: FMA:56432 +xref: MESH:D000080869 xref: NCIT:C12496 xref: SCTID:361735006 xref: UMLS:C0222712 {source="ncithesaurus:Jugular_Foramen"} @@ -270767,6 +382304,14 @@ property_value: UBPROP:0000001 "Large foramen that houses the glossopharyngeal a property_value: UBPROP:0000001 "One of a pair of openings between the lateral part of the occipital bone and the petrous part of the temporal bones in the skull. The foramen contains the inferior petrosal sinus; the transverse sinus; some meningeal branches of the occipital and ascending pharyngeal arteries; and the glossopharyngeal, vagus, and accessory nerves. [Free_Online_Medical_Dictionary]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001113", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/jugular+foramen"} property_value: UBPROP:0000002 "relationship loss: subclass braincase and otic capsule opening (AAO:0000051)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000249", ontology="AAO"} +[Term] +id: UBERON:0005457 +name: left thymus lobe +is_a: UBERON:0005483 ! thymus lobe +intersection_of: UBERON:0005483 ! thymus lobe +intersection_of: in_left_side_of UBERON:0002370 ! thymus +relationship: in_left_side_of UBERON:0002370 ! thymus + [Term] id: UBERON:0005459 name: left umbilical vein @@ -270781,6 +382326,41 @@ is_a: UBERON:0002066 ! umbilical vein is_a: UBERON:0015212 ! lateral structure property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI +[Term] +id: UBERON:0005460 +name: left vitelline vein +namespace: uberon +def: "A vitelline vein that is in the left side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0000971 +xref: EMAPA:16380 +xref: EMAPA:16698 +xref: FMA:70307 +xref: SCTID:361446008 +is_a: UBERON:0005487 ! vitelline vein +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0005487 ! vitelline vein +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI + +[Term] +id: UBERON:0005461 +name: levator scapulae muscle +is_a: UBERON:0001482 ! muscle of shoulder +is_a: UBERON:0003897 ! axial muscle +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004518 ! muscle of vertebral column +is_a: UBERON:0034908 ! scapular muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0002413 ! cervical vertebra +intersection_of: attaches_to UBERON:0006849 ! scapula +relationship: attaches_to UBERON:0002413 ! cervical vertebra +relationship: develops_from UBERON:0010983 ! levator scapulae pre-muscle mass +relationship: has_muscle_insertion UBERON:0007174 ! medial border of scapula +relationship: has_muscle_origin UBERON:0001077 ! transverse process of vertebra +relationship: innervated_by UBERON:0000962 ! nerve of cervical vertebra +relationship: part_of UBERON:0008713 ! pectoral girdle and thoracic body wall skeletal muscle + [Term] id: UBERON:0005462 name: lower back @@ -270811,6 +382391,19 @@ relationship: part_of UBERON:0001137 ! dorsum relationship: part_of UBERON:0002417 {source="MA"} ! abdominal segment of trunk property_value: UBPROP:0000007 "lumbar" xsd:string +[Term] +id: UBERON:0005463 +name: subcapsular sinus of lymph node +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: adjacent_to UBERON:0002006 ! cortex of lymph node +intersection_of: adjacent_to UBERON:0002194 ! capsule of lymph node +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: adjacent_to UBERON:0002006 ! cortex of lymph node +relationship: adjacent_to UBERON:0002194 ! capsule of lymph node +relationship: part_of UBERON:0000029 ! lymph node + [Term] id: UBERON:0005467 name: platysma @@ -270840,6 +382433,31 @@ property_value: seeAlso https://github.com/obophenotype/uberon/issues/472 xsd:an property_value: UBPROP:0000001 "The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve, and attaches to the skin.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} property_value: UBPROP:0000003 "One of these (facial muscles in mammals), the platysma, is an unspecialized muscle derived from the hyoid arch.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000931", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.398", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005469 +name: right thymus lobe +is_a: UBERON:0005483 ! thymus lobe +intersection_of: UBERON:0005483 ! thymus lobe +intersection_of: in_right_side_of UBERON:0002370 ! thymus +relationship: in_right_side_of UBERON:0002370 ! thymus + +[Term] +id: UBERON:0005472 +name: right vitelline vein +namespace: uberon +def: "A vitelline vein that is in the right side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0001766 +xref: EMAPA:16381 +xref: EMAPA:16699 +xref: FMA:70306 +xref: SCTID:361445007 +is_a: UBERON:0005487 ! vitelline vein +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0005487 ! vitelline vein +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI + [Term] id: UBERON:0005473 name: sacral region @@ -270856,12 +382474,28 @@ synonym: "sacral part of pelvis" EXACT [FMA:24228] xref: FMA:24228 xref: SCTID:182344001 xref: Wikipedia:Sacrum +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: has_skeleton UBERON:0006075 ! sacral region of vertebral column relationship: part_of UBERON:0002355 ! pelvic region of trunk property_value: UBPROP:0000007 "pygal" xsd:string property_value: UBPROP:0000007 "sacral" xsd:string property_value: UBPROP:0000008 "Amphibians - 1 sacral vertebra; Living reptiles & most birds - 2 sacral vertebrae; Most mammals - 3 to 5 sacral vertebrae. TODO - split sacral from sacrococcygeal" xsd:string +[Term] +id: UBERON:0005475 +name: sigmoid sinus +is_a: UBERON:0017635 ! paired venous dural sinus +relationship: tributary_of UBERON:0001586 ! internal jugular vein + +[Term] +id: UBERON:0005477 +name: stomach fundus epithelium +is_a: UBERON:0001276 ! epithelium of stomach +intersection_of: UBERON:0000485 ! simple columnar epithelium +intersection_of: part_of UBERON:0001160 ! fundus of stomach +relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach + [Term] id: UBERON:0005478 name: sulcus limitans of neural tube @@ -270871,7 +382505,7 @@ synonym: "neural tube lateral wall sulcus limitans" EXACT [EHDAA2:0001265] synonym: "sulcus limitans" BROAD [] xref: BAMS:slim xref: BAMS:slm -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=629 +xref: neuronames:629 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006846 ! surface groove relationship: part_of UBERON:0005496 {source="EHDAA2"} ! neural tube lateral wall @@ -270881,6 +382515,7 @@ id: UBERON:0005483 name: thymus lobe namespace: uberon def: "Either of the two lateral lobes that constitute the thymus." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas synonym: "lateral lobe of thymus" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "lobe of thymus" EXACT [FMA:71193] xref: FMA:71193 @@ -270888,7 +382523,11 @@ xref: RETIRED_EHDAA2:0002021 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0009912 ! anatomical lobe is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0009912 ! anatomical lobe +intersection_of: part_of UBERON:0002370 ! thymus +relationship: in_lateral_side_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000010 "each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. Each lobe is composed of numerous lobules held together by delicate areolar tissue; the entire organ being enclosed in an investing capsule of a similar but denser structure. The primary lobules vary in size from that of a pin's head to that of a small pea, and are made up of a number of small nodules or follicles.[WP]" xsd:string [Term] @@ -270907,7 +382546,11 @@ xref: MA:0003180 xref: RETIRED_EHDAA2:0002082 xref: SCTID:276830008 xref: VHOG:0000821 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0011741 ! cardiac valve leaflet +intersection_of: UBERON:0011741 ! cardiac valve leaflet +intersection_of: part_of UBERON:0002134 ! tricuspid valve +relationship: attaches_to UBERON:0014851 ! chorda tendinea of left ventricle relationship: part_of UBERON:0002134 ! tricuspid valve property_value: UBPROP:0000001 "Leaf of caridac valve which has as its parts the anterior, posterior and septal leaflets that is is attached to the chorda tendinea of the right ventricle and the fibrous ring of tricuspid valve." xsd:string {source="FMA:7237"} property_value: UBPROP:0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000821", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} @@ -270937,6 +382580,17 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6c/G property_value: editor_note "this class should be subdivided into the embryonic structure and the vestigial adult remnant, a small endocardialfold" xsd:string property_value: UBPROP:0000001 "Vestigial cardiac valve which is continuous with the valve of the coronary sinus and the crista terminalis." xsd:string {source="FMA:9240"} +[Term] +id: UBERON:0005486 +name: venous dural sinus +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0006615 ! venous sinus +intersection_of: UBERON:0006615 ! venous sinus +intersection_of: located_in UBERON:0002363 ! dura mater +relationship: located_in UBERON:0002363 ! dura mater +relationship: part_of UBERON:0003711 ! brachiocephalic vein +relationship: part_of UBERON:0010743 ! meningeal cluster + [Term] id: UBERON:0005487 name: vitelline vein @@ -270963,6 +382617,9 @@ xref: XAO:0000376 xref: XAO:0004147 is_a: UBERON:0004365 ! vitelline blood vessel is_a: UBERON:0013140 ! systemic vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001040 ! yolk sac +relationship: drains UBERON:0001040 ! yolk sac property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png xsd:anyURI property_value: UBPROP:0000001 "One of two veins that run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.[XAO]" xsd:string {ontology="XAO", source="XAO:0004147"} property_value: UBPROP:0000003 "Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000401", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460", source="http://bgee.unil.ch/"} @@ -270998,6 +382655,7 @@ xref: XAO:0004154 xref: ZFA:0005046 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure +relationship: part_of UBERON:0000922 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! embryo relationship: part_of UBERON:0002203 {source="ZFA-modified"} ! vasculature of eye property_value: editor_note "we are currently conflating vessel and vasculature - we may wish to split this class - see also vascular plexus term. The ZFA class represents the vasculature" xsd:string @@ -271143,6 +382801,8 @@ xref: TAO:0001311 xref: VHOG:0001018 xref: ZFA:0001311 is_a: UBERON:0003054 ! roof plate +intersection_of: UBERON:0003054 ! roof plate +intersection_of: part_of UBERON:0001892 ! rhombomere relationship: part_of UBERON:0001892 ! rhombomere [Term] @@ -271298,6 +382958,7 @@ xref: TAO:0001077 xref: ZFA:0001077 is_a: UBERON:0001048 ! primordium is_a: UBERON:0003351 ! pharyngeal epithelium +relationship: has_developmental_contribution_from UBERON:0005428 ! vagal neural crest relationship: part_of UBERON:0002405 {source="ZFA"} ! immune system relationship: part_of UBERON:0003295 {source="EHDAA2"} ! pharyngeal gland property_value: editor_note "we follow Kardong table 13.1 in having some developmental contribution of pouch 4 in mammals, but this isn't reflected in EHDAA2. Consider adding distinct term for mesenchyme (see EHDAA2), to indicate NC constribution." xsd:string {source="ISBN:0781714125"} @@ -271371,6 +383032,14 @@ is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population relationship: develops_from UBERON:0003849 {source="EHDAA2"} ! mesencephalic neural crest property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000268", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005567 +name: rhombomere 1 lateral wall +is_a: UBERON:0005501 ! rhombomere lateral wall +intersection_of: UBERON:0005501 ! rhombomere lateral wall +intersection_of: part_of UBERON:0005499 ! rhombomere 1 +relationship: part_of UBERON:0005499 ! rhombomere 1 + [Term] id: UBERON:0005568 name: rhombomere 1 roof plate @@ -271384,6 +383053,8 @@ xref: EMAPA:16483 xref: TAO:0001033 xref: ZFA:0001033 is_a: UBERON:0005502 ! rhombomere roof plate +intersection_of: UBERON:0005502 ! rhombomere roof plate +intersection_of: part_of UBERON:0005499 ! rhombomere 1 relationship: part_of UBERON:0005499 ! rhombomere 1 [Term] @@ -271533,6 +383204,14 @@ is_a: UBERON:0002394 ! bile duct relationship: part_of UBERON:0003703 {source="MA"} ! extrahepatic bile duct relationship: part_of UBERON:0005171 {source="MA"} ! hepatic duct +[Term] +id: UBERON:0005606 +name: hyaloid cavity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +is_a: UBERON:0012467 ! enclosed anatomical space +relationship: part_of UBERON:0002203 ! vasculature of eye + [Term] id: UBERON:0005609 name: iliac artery @@ -271553,6 +383232,7 @@ xref: Wikipedia:Iliac_artery xref: XAO:0000361 is_a: UBERON:0004573 ! systemic artery relationship: part_of UBERON:0010709 ! pelvic complex +relationship: supplies UBERON:0002355 ! pelvic region of trunk property_value: IAO:0000232 "this is an extremely loose and flexible grouping class that is the superclass of the mammalian common iliac and its main brahces, together with analagous structures in other tetrapods" xsd:string property_value: UBPROP:0000012 "we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific" xsd:string {external_ontology="XAO"} @@ -271638,12 +383318,16 @@ xref: VHOG:0001117 xref: Wikipedia:Mesenteric_artery xref: XAO:0000370 is_a: UBERON:0012254 ! abdominal aorta artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0000160 ! intestine +relationship: supplies UBERON:0000160 ! intestine property_value: editor_note "includes posterior and anterior mesenteric arteries, which branch from the dorsal aorta (see Kardong), and superior and inferior mesenteric arteries" xsd:string [Term] id: UBERON:0005617 name: mesenteric vein namespace: uberon +def: "A vein that returns blood from the intestines." [MESH:A07.231.908.670.385, Wikipedia:Mesenteric_vein] def: "A vein that returns blood from the intestines." [http://en.wikipedia.org/wiki/Mesenteric_vein, MESH:A07.231.908.670.385] synonym: "intestinal vein" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0002781 @@ -271656,7 +383340,9 @@ xref: Mesenteric:vein xref: MESH:D008642 xref: NCIT:C53055 xref: RETIRED_EHDAA2:0001125 +xref: SCTID:304045008 xref: UMLS:C0025473 {source="ncithesaurus:Mesenteric_Vein"} +xref: Wikipedia:Mesenteric_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0000160 ! intestine @@ -271750,6 +383436,32 @@ is_a: UBERON:0000946 ! cardial valve property_value: UBPROP:0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001393", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000010 "Lacks chordae tendinae" xsd:string +[Term] +id: UBERON:0005624 +name: suprarenal artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002369 ! adrenal gland +relationship: supplies UBERON:0002369 ! adrenal gland + +[Term] +id: UBERON:0005625 +name: tubotympanic recess lumen +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +is_a: UBERON:0007473 ! lumen of epithelial sac +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0010020 ! tubotympanic recess epithelium +relationship: develops_from UBERON:0007122 ! pharyngeal pouch 1 +relationship: luminal_space_of UBERON:0010020 ! tubotympanic recess epithelium +relationship: part_of UBERON:0001756 ! middle ear + +[Term] +id: UBERON:0005626 +name: ventral mesogastrium +is_a: UBERON:0003281 ! mesentery of stomach +relationship: part_of UBERON:0009668 ! ventral mesentery + [Term] id: UBERON:0005629 name: vascular plexus @@ -271761,7 +383473,9 @@ xref: EHDAA2:0004112 xref: EMAPA:35904 xref: FMA:5900 xref: XAO:0004143 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002049 ! vasculature +relationship: has_part UBERON:0001981 ! blood vessel property_value: UBPROP:0000001 "In a vascular plexus, the contents of the vessels mix. A plexus allows blood to flow via multiple routes. If one branch of the plexus is obstructed, the blood may flow via the open branches[Wikipedia:Plexus#Circulatory_system]." xsd:string {source="Wikipedia:Plexus#Circulatory_system"} [Term] @@ -271771,6 +383485,7 @@ namespace: uberon def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." [ISBN:0073040584] xref: EHDAA2:0004714 xref: FMA:305915 +xref: MESH:D005321 xref: SCTID:362840007 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000158 ! membranous layer @@ -271779,6 +383494,27 @@ property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-ext property_value: UBPROP:0000008 "stuctures homologous to the four extraembryonic membranes appear in mammals [ISBN:0073040584 (Vertebrates, Kardong)]" xsd:string property_value: UBPROP:0000012 "EHDAA2 is a mereological sum." xsd:string {external_ontology="EHDAA2"} +[Term] +id: UBERON:0005636 +name: caecum epithelium +is_a: UBERON:0000397 ! colonic epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001153 ! caecum +relationship: part_of UBERON:0001153 ! caecum + +[Term] +id: UBERON:0005637 +name: pyloric region epithelium +namespace: uberon +def: "An epithelium that is part of a pylorus." [OBOL:automatic] +xref: EHDAA2:0001582 +xref: EMAPA:17633 +xref: RETIRED_EHDAA2:0001927 +is_a: UBERON:0001276 ! epithelium of stomach +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001166 ! pylorus +relationship: part_of UBERON:0001166 ! pylorus + [Term] id: UBERON:0005638 name: anterior chamber epithelium @@ -271790,6 +383526,22 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball relationship: part_of UBERON:0001766 ! anterior chamber of eyeball +[Term] +id: UBERON:0005648 +name: manual digit 5 epithelium +is_a: UBERON:0005227 ! manual digit epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003625 ! manual digit 5 +relationship: part_of UBERON:0003625 ! manual digit 5 + +[Term] +id: UBERON:0005652 +name: pedal digit 5 epithelium +is_a: UBERON:0005226 ! pedal digit epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003635 ! pedal digit 5 +relationship: part_of UBERON:0003635 ! pedal digit 5 + [Term] id: UBERON:0005656 name: lens vesicle epithelium @@ -271803,6 +383555,16 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0005426 ! lens vesicle relationship: part_of UBERON:0005426 ! lens vesicle +[Term] +id: UBERON:0005658 +name: secondary palatal shelf epithelium +is_a: UBERON:0003235 ! epithelium of upper jaw +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0005619 ! secondary palatal shelf +relationship: part_of UBERON:0005619 ! secondary palatal shelf + [Term] id: UBERON:0005660 name: 2nd arch ectoderm @@ -271911,6 +383673,13 @@ intersection_of: part_of UBERON:0003115 ! pharyngeal arch 4 relationship: part_of UBERON:0003115 ! pharyngeal arch 4 property_value: UBPROP:0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001092", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005667 +name: connecting stalk mesoderm +is_a: UBERON:0003422 ! mesenchyme of umbilical cord +is_a: UBERON:0007524 ! dense mesenchyme tissue +relationship: develops_from UBERON:0005728 ! extraembryonic mesoderm + [Term] id: UBERON:0005669 name: peritoneal cavity mesothelium @@ -271933,6 +383702,14 @@ intersection_of: located_in UBERON:0001179 ! peritoneal cavity relationship: located_in UBERON:0001179 ! peritoneal cavity property_value: UBPROP:0000012 "we believe that this corresponds to EMAPA:16139 based on synonyms and parenthood" xsd:string {external_ontology="EMAPA"} +[Term] +id: UBERON:0005670 +name: greater omentum mesothelium +is_a: UBERON:0001136 ! mesothelium +intersection_of: UBERON:0001136 ! mesothelium +intersection_of: part_of UBERON:0005448 ! greater omentum +relationship: part_of UBERON:0005448 ! greater omentum + [Term] id: UBERON:0005672 name: right lung endothelium @@ -271957,6 +383734,37 @@ is_a: UBERON:0003365 ! epithelium of left lung intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0002168 ! left lung +[Term] +id: UBERON:0005677 +name: caecum mesentery +is_a: UBERON:0003396 ! mesentery of colon +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0001153 ! caecum +relationship: part_of UBERON:0001153 ! caecum + +[Term] +id: UBERON:0005685 +name: midgut dorsal mesentery +namespace: uberon +def: "A dorsal mesentery that is part of a midgut." [OBOL:automatic] +xref: EMAPA:16722 +xref: EMAPA:17040 +xref: EMAPA:18671 +xref: RETIRED_EHDAA2:0001187 +xref: SCTID:361434009 +is_a: UBERON:0002296 ! dorsal mesentery +intersection_of: UBERON:0002296 ! dorsal mesentery +intersection_of: part_of UBERON:0001045 ! midgut +relationship: part_of UBERON:0001045 ! midgut + +[Term] +id: UBERON:0005686 +name: caecum dorsal mesentery +is_a: UBERON:0002296 ! dorsal mesentery +intersection_of: UBERON:0002296 ! dorsal mesentery +intersection_of: part_of UBERON:0001153 ! caecum +relationship: part_of UBERON:0001153 ! caecum + [Term] id: UBERON:0005687 name: orbitosphenoid cartilage element @@ -271971,6 +383779,8 @@ is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest is_a: UBERON:0015059 ! orbitosphenoid endochondral element +intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010728 {source="EHDAA2"} ! sphenoid lesser wing pre-cartilage condensation relationship: part_of UBERON:0009193 {source="EHDAA2"} ! sphenoid cartilage element @@ -272052,6 +383862,22 @@ intersection_of: part_of UBERON:0003115 ! pharyngeal arch 4 relationship: part_of UBERON:0003115 ! pharyngeal arch 4 property_value: UBPROP:0000003 "In all vertebrates, the pharyngeal apparatus develops from a series of bulges found on the lateral surface of the head, the pharyngeal arches, which consist of a number of different embryonic cell types. Each arch has an external covering of ectoderm and inner covering of endoderm, and between these a mesenchymal filling of neural crest with a central core of mesoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001052", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005695 +name: manual digit 5 mesenchyme +is_a: UBERON:0005257 ! manual digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003625 ! manual digit 5 +relationship: part_of UBERON:0003625 ! manual digit 5 + +[Term] +id: UBERON:0005699 +name: pedal digit 5 mesenchyme +is_a: UBERON:0005255 ! pedal digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003635 ! pedal digit 5 +relationship: part_of UBERON:0003635 ! pedal digit 5 + [Term] id: UBERON:0005702 name: optic eminence mesenchyme @@ -272067,6 +383893,49 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0004348 ! optic eminence relationship: part_of UBERON:0004348 ! optic eminence +[Term] +id: UBERON:0005704 +name: secondary palatal shelf mesenchyme +is_a: UBERON:0003323 ! mesenchyme of upper jaw +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0005619 ! secondary palatal shelf +relationship: part_of UBERON:0005619 ! secondary palatal shelf + +[Term] +id: UBERON:0005711 +name: foregut duodenum mesentery +namespace: uberon +def: "A mesentery of duodenum that is part of a foregut." [OBOL:automatic] +xref: EHDAA2:0000564 +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: part_of UBERON:0001041 ! foregut +relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm +relationship: part_of UBERON:0001041 ! foregut + +[Term] +id: UBERON:0005712 +name: midgut duodenum mesentery +namespace: uberon +def: "A mesentery of duodenum that is part of a midgut." [OBOL:automatic] +xref: EHDAA2:0001193 +is_a: UBERON:0003284 ! mesentery of midgut +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: part_of UBERON:0001045 ! midgut +relationship: develops_from UBERON:0011642 ! oral epithelium from ectoderm + +[Term] +id: UBERON:0005719 +name: footplate apical ectodermal ridge +is_a: UBERON:0004356 ! apical ectodermal ridge +intersection_of: UBERON:0004356 ! apical ectodermal ridge +intersection_of: part_of UBERON:0006871 ! embryonic footplate +relationship: part_of UBERON:0003373 ! ectoderm of footplate + [Term] id: UBERON:0005720 name: hindbrain venous system @@ -272111,6 +383980,17 @@ relationship: immediate_transformation_of UBERON:0007297 {source="Bgee:AN"} ! pr relationship: part_of UBERON:0003064 {source="ZFA"} ! intermediate mesoderm property_value: UBPROP:0000001 "Portion of tissue that consists of the mesenchymal precursor to the pronephric kidney and that begins to separate from the intermediate mesoderm at NF stage 21 and epithelializes by NF stage 30.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011090", ontology="AAO", source="XAO:curator"} +[Term] +id: UBERON:0005724 +name: roof plate spinal cord region +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0002240 ! spinal cord +intersection_of: part_of UBERON:0003054 ! roof plate +relationship: part_of UBERON:0002240 ! spinal cord +relationship: part_of UBERON:0003054 ! roof plate + [Term] id: UBERON:0005725 name: olfactory system @@ -272140,6 +384020,9 @@ xref: Wikipedia:Olfactory_system xref: XAO:0003196 xref: ZFA:0001149 is_a: UBERON:0005726 ! chemosensory system +intersection_of: UBERON:0001032 ! sensory system +intersection_of: capable_of GO:0007608 ! sensory perception of smell +relationship: capable_of GO:0007608 ! sensory perception of smell relationship: existence_ends_during UBERON:0000066 ! fully formed stage property_value: editor_note "consider splitting into main and accessory. See also: vomeronasal organ" xsd:string property_value: editor_note "we make the relationship to nervous system 'overlaps', as the olfactory system includes e.g. apertures in the cranium that are not part of the nervous system" xsd:string @@ -272270,6 +384153,7 @@ is_a: UBERON:0004797 {source="cjm"} ! blood vessel layer is_a: UBERON:0005742 ! adventitia relationship: composed_primarily_of UBERON:0011824 ! fibrous connective tissue relationship: has_quality PATO:0002462 ! collagenous +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg xsd:anyURI property_value: depicted:by Illu:artery.jpg xsd:anyURI property_value: editor_note "TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings" xsd:string property_value: UBPROP:0000001 "The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]." xsd:string {source="http://en.wikipedia.org/wiki/Tunica_externa_(vessels)"} @@ -272301,6 +384185,7 @@ namespace: uberon def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [Wikipedia:Adventitia] def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [http://en.wikipedia.org/wiki/Adventitia] subset: grouping_class +subset: human_reference_atlas synonym: "tunica advetitia" NARROW [http://en.wikipedia.org/wiki/Adventitia] synonym: "tunica advetitia" NARROW [Wikipedia:Adventitia] synonym: "tunica externa" NARROW [FMA:45635] @@ -272308,12 +384193,13 @@ xref: BTO:0002010 xref: FMA:45635 xref: http://en.wikipedia.org/wiki/Adventitia xref: http://www.snomedbrowser.com/Codes/Details/30180000 +xref: MESH:D063194 xref: SCTID:30180000 xref: Wikipedia:Adventitia -is_a: BFO:0000040 ! material entity is_a: UBERON:0004923 ! organ component layer relationship: composed_primarily_of UBERON:0002384 ! connective tissue property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005744 @@ -272364,8 +384250,13 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0013685 ! foramen of skull is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: conduit_for UBERON:0000941 ! cranial nerve II +relationship: conduit_for UBERON:0000941 ! cranial nerve II +relationship: conduit_for UBERON:0001619 ! ophthalmic artery +relationship: in_lateral_side_of UBERON:0001677 ! sphenoid bone relationship: part_of UBERON:0002478 ! orbitosphenoid -property_value: depicted:by Orbita:mensch.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg xsd:anyURI property_value: UBPROP:0000001 "An aperture in the root of the lesser wing of the sphenoid bone transmitting the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001408", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+foramen"} property_value: UBPROP:0000001 "Foramen in the orbital region of the neurocranium for the passage of the optic nerve (cranial nerve II).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002025", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000001 "The short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery" xsd:string {external_class="MP:0010704", ontology="MP"} @@ -272401,6 +384292,7 @@ xref: SCTID:362217000 xref: Wikipedia:Glomerulus is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: capable_of_part_of GO:0003094 ! glomerular filtration relationship: develops_from UBERON:0003220 {source="Wikipedia"} ! metanephric mesenchyme relationship: part_of UBERON:0001230 ! glomerular capsule property_value: UBPROP:0000011 "...Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus" xsd:string {source="GudMap"} @@ -272410,6 +384302,7 @@ id: UBERON:0005750 name: glomerular parietal epithelium namespace: uberon def: "A single layer of simple squamous epithelium in the glomerular capsule. Does not function in filtration[UBERON]. outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium[MP]." [https://orcid.org/0000-0002-6601-2165, MP:0011498] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "Bowman's parietal epithelium" EXACT [MP:0011498] @@ -272440,13 +384333,15 @@ is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0004188 ! glomerular epithelium relationship: part_of UBERON:0001230 ! glomerular capsule property_value: editor_note "TODO - check this. BTO has podocytes under here" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Simple squamous epithelium that lines the capsule of the renal glomerulus.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005253", ontology="TAO", source="ZFIN:curator"} [Term] id: UBERON:0005751 -name: visceral layer of glomerular capsule +name: glomerular visceral epithelium namespace: uberon -def: "The inner, or visceral, layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer, or parietal, layer by the capsular (Bowman's) space[BTO]. Lies just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]." [BTO:0001515, MP:0011497] +def: "The inner (visceral) layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer (parietal) layer by the capsular (Bowman's) space[BTO]. This epithelial layer is superficially adjacent to the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. This inner epithelial layer of the glomerular capsule surrounds the capillary endothelial cells and is composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the inner visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]." [BTO:0001515, MP:0011497] +comment: Formerly had rdfs:label 'visceral layer of glomerular capsule'. The current label 'glomerular visceral epithelium' was copied from UBERON:0006852, which is now obsolete since it represented the same entity as this IRI. subset: inconsistent_with_fma subset: pheno_slim synonym: "Bowman's visceral epithelium" EXACT [MP:0011497] @@ -272457,11 +384352,13 @@ synonym: "visceral epithelium of Bowman's capsule" EXACT [MP:0011497] synonym: "visceral epithelium of Bowman's capsule" EXACT [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron] synonym: "visceral layer of Bowman's capsule" EXACT [MP:0011497] synonym: "visceral layer of glomerular capsule" EXACT [MP:0011497] +xref: EMAPA:28254 xref: FMA:74273 +xref: MA:0002607 xref: NCIT:C33879 xref: SCTID:244093000 xref: UMLS:C0227644 {source="ncithesaurus:Visceral_Layer_of_Bowman_s_Capsule"} -is_a: UBERON:0004211 ! nephron epithelium +is_a: UBERON:0004188 ! glomerular epithelium relationship: part_of UBERON:0001230 ! glomerular capsule property_value: editor_note "TODO - check - the BTO class 'glomerular epithelium' is the visceral layer. But GO uses 'glomerular epithelium' as the mereological sum of P+V layers" xsd:string @@ -272507,6 +384404,7 @@ xref: UMLS:C1519838 {source="ncithesaurus:Urorectal_Septum"} xref: VHOG:0000018 xref: Wikipedia:Urorectal_septum is_a: UBERON:0003037 ! septum +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0001008 {source="MA"} ! renal system relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray992.png xsd:anyURI @@ -272521,7 +384419,6 @@ namespace: uberon def: "A acellular anatomical structure that is the bounding layer of a anatomical structure." [OBOL:automatic] def: "An acellular anatomical structure that is the bounding layer of a anatomical structure." [OBOL:automatic] xref: FMA:63871 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: bounding_layer_of UBERON:0000061 ! anatomical structure @@ -272571,6 +384468,7 @@ xref: EMAPA:28251 xref: EMAPA:30965 xref: FMA:74274 xref: MA:0001659 +xref: MESH:D050533 xref: NCIT:C32683 xref: SCTID:243897006 xref: TAO:0005285 @@ -272579,10 +384477,24 @@ xref: Wikipedia:Glomerular_basement_membrane xref: ZFA:0005285 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005769 ! basement membrane of epithelium +intersection_of: UBERON:0005769 ! basement membrane of epithelium +intersection_of: part_of UBERON:0000074 ! renal glomerulus +relationship: capable_of GO:0003094 ! glomerular filtration relationship: part_of UBERON:0004188 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! glomerular epithelium property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/de/PhysiologieGlom%C3%A9rulaire.png xsd:anyURI property_value: UBPROP:0000001 "Membrane between the mesonephric podocytes and the renal glomerular capillaries. It is a trilaminar structure composed of the fused basement membranes of the glomerular capillaries and basement membrane of the podocytes. The capillary membranes touch the GBM at contact points that are separated by pores. The membrane is semi-permeable allowing water and small molecules to pass into the renal capsular space.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005285", ontology="TAO", source="ZFIN:ZDB-PUB-000824-1"} +[Term] +id: UBERON:0005788 +name: lamina rara interna +is_a: UBERON:0000476 ! acellular anatomical structure +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000476 ! acellular anatomical structure +intersection_of: adjacent_to UBERON:0001230 ! glomerular capsule +intersection_of: part_of UBERON:0005777 ! glomerular basement membrane +relationship: adjacent_to UBERON:0001230 ! glomerular capsule +relationship: part_of UBERON:0005777 ! glomerular basement membrane + [Term] id: UBERON:0005792 name: nephric ridge @@ -272606,6 +384518,7 @@ synonym: "fetal uterus" EXACT [FMA:72173] xref: FMA:72173 xref: SCTID:255782009 is_a: UBERON:0006598 ! presumptive structure +relationship: has_potential_to_develop_into UBERON:0000995 ! uterus [Term] id: UBERON:0005800 @@ -272682,6 +384595,8 @@ synonym: "osseous tissue of long bone" RELATED [FMA:83117] xref: FMA:83117 xref: SCTID:425475006 is_a: UBERON:0002481 ! bone tissue +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0002495 ! long bone relationship: part_of UBERON:0002495 ! long bone [Term] @@ -272755,7 +384670,7 @@ synonym: "flexura mesencephalica" RELATED LATIN [Wikipedia:Cephalic_flexure] synonym: "mesencephalic flexure" EXACT [http://www.dartmouth.edu/~rswenson/NeuroSci/chapter_4.html] synonym: "midbrain flexure" EXACT [MP:0004203] synonym: "ventral flexure" EXACT [ZFA:0001640] -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1360 +xref: neuronames:1360 xref: TAO:0002181 xref: Wikipedia:Cephalic_flexure xref: ZFA:0001640 @@ -272771,7 +384686,7 @@ name: cervical flexure namespace: uberon def: "A ventrally concave flexure of the embryonic brain occurring at the junction of hindbrain and spinal cord[MP]." [MP:0000913] subset: pheno_slim -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1359 +xref: neuronames:1359 is_a: UBERON:0005817 ! neuraxis flexure relationship: part_of UBERON:0007277 ! presumptive hindbrain property_value: UBPROP:0000008 "In humans develops by the 5th week of gestation" xsd:string {source="WP"} @@ -272786,7 +384701,7 @@ synonym: "(embryonic) hindbrain flexure" EXACT [MP:0000844] synonym: "basicranial flexure" EXACT [MP:0000844] synonym: "pontal flexure" EXACT [MP:0000844] synonym: "transverse rhombencephalic flexure" EXACT [MP:0000844] -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1361 +xref: neuronames:1361 xref: Wikipedia:Pontine_flexure is_a: UBERON:0005817 ! neuraxis flexure relationship: part_of UBERON:0007277 ! presumptive hindbrain @@ -272818,6 +384733,14 @@ intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0002316 ! white matter +[Term] +id: UBERON:0005843 +name: sacral spinal cord +is_a: UBERON:0005844 ! spinal cord segment +intersection_of: UBERON:0005844 ! spinal cord segment +intersection_of: adjacent_to UBERON:0005473 ! sacral region +relationship: adjacent_to UBERON:0005473 ! sacral region + [Term] id: UBERON:0005844 name: spinal cord segment @@ -272833,6 +384756,14 @@ xref: SCTID:278748001 is_a: UBERON:0001948 ! regional part of spinal cord property_value: editor_note "This is currently used loosely to refer to cervical, lumbar, etc as well as the metamerically repeated segments, which may correspond more closely with the ZFA neuromere term" xsd:string +[Term] +id: UBERON:0005845 +name: caudal segment of spinal cord +is_a: UBERON:0005844 ! spinal cord segment +intersection_of: UBERON:0005844 ! spinal cord segment +intersection_of: adjacent_to UBERON:0006071 ! caudal region +relationship: adjacent_to UBERON:0006071 ! caudal region + [Term] id: UBERON:0005856 name: developing mesenchymal condensation @@ -272970,6 +384901,7 @@ xref: XAO:0004073 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0016566 {source="EHDAA2"} ! pit relationship: develops_from UBERON:0003050 {source="XAO:0000275 nasal pit"} ! olfactory placode +relationship: located_in UBERON:0005384 ! nasal cavity epithelium relationship: part_of UBERON:0000004 {source="EMAPA"} ! nose relationship: part_of UBERON:0000922 ! embryo property_value: editor_note "we represent the relationship as develops from, though in fact the pit is formed as an indentation in the placode" xsd:string @@ -273018,8 +384950,43 @@ xref: EMAPA:16119 xref: VHOG:0000554 xref: VHOG:0000969 is_a: UBERON:0005879 ! pharyngeal cleft +intersection_of: UBERON:0005879 ! pharyngeal cleft +intersection_of: overlaps UBERON:0003066 ! pharyngeal arch 2 +intersection_of: overlaps UBERON:0004362 ! pharyngeal arch 1 +relationship: overlaps UBERON:0003066 ! pharyngeal arch 2 +relationship: overlaps UBERON:0004362 ! pharyngeal arch 1 property_value: UBPROP:0000003 "In all jawed vertebrates the first arch forms the jaw, while the second arch forms the hyoid apparatus. These two arches are separated by the first pharyngeal pouch and cleft.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000969", ontology="VHOG", source="DOI:10.1016/j.semcdb.2010.01.022 Grevellec A, Tucker AS, The pharyngeal pouches and clefts: development, evolution, structure and derivatives. Seminars in Cell and Developmental Biology (2010)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0005873 +name: 2nd arch pharyngeal cleft +is_a: UBERON:0005879 ! pharyngeal cleft +intersection_of: UBERON:0005879 ! pharyngeal cleft +intersection_of: overlaps UBERON:0003066 ! pharyngeal arch 2 +intersection_of: overlaps UBERON:0003114 ! pharyngeal arch 3 +relationship: overlaps UBERON:0003066 ! pharyngeal arch 2 +relationship: overlaps UBERON:0003114 ! pharyngeal arch 3 + +[Term] +id: UBERON:0005874 +name: 3rd arch pharyngeal cleft +is_a: UBERON:0005879 ! pharyngeal cleft +intersection_of: UBERON:0005879 ! pharyngeal cleft +intersection_of: overlaps UBERON:0003114 ! pharyngeal arch 3 +intersection_of: overlaps UBERON:0003115 ! pharyngeal arch 4 +relationship: overlaps UBERON:0003114 ! pharyngeal arch 3 +relationship: overlaps UBERON:0003115 ! pharyngeal arch 4 + +[Term] +id: UBERON:0005875 +name: 4th arch pharyngeal cleft +is_a: UBERON:0005879 ! pharyngeal cleft +intersection_of: UBERON:0005879 ! pharyngeal cleft +intersection_of: overlaps UBERON:0003115 ! pharyngeal arch 4 +intersection_of: overlaps UBERON:0003116 ! pharyngeal arch 5 +relationship: overlaps UBERON:0003115 ! pharyngeal arch 4 +relationship: overlaps UBERON:0003116 ! pharyngeal arch 5 + [Term] id: UBERON:0005876 name: undifferentiated genital tubercle @@ -273041,6 +385008,8 @@ xref: Wikipedia:Genital_tubercle is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: develops_from UBERON:0004874 ! somatopleure +relationship: has_potential_to_develop_into UBERON:0011757 ! differentiated genital tubercle +relationship: only_in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0009196 {source="EHDAA2"} ! indifferent external genitalia property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d6/Gray1119.png xsd:anyURI property_value: UBPROP:0000001 "embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until ~E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP]" xsd:string {ontology="MP"} @@ -273074,6 +385043,8 @@ xref: UMLS:C1280559 {source="ncithesaurus:Pharyngeal_Groove"} xref: Wikipedia:Pharyngeal_groove is_a: UBERON:0006846 {source="EHDAA2"} ! surface groove is_a: UBERON:0016545 ! pharyngeal ectoderm +relationship: adjacent_to UBERON:0004117 ! pharyngeal pouch +relationship: overlaps UBERON:0002539 ! pharyngeal arch property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/20/Kiemenbogen.jpg xsd:anyURI property_value: editor_note "Note we use overlaps as the relationship to the arches" xsd:string property_value: UBPROP:0000012 "EMAPA distinguishes between the groove ectoderm and epithelium, with the latter arising after the former" xsd:string {external_ontology="EMAPA"} @@ -273101,7 +385072,7 @@ synonym: "dorsal part of neural tube" RELATED [] synonym: "lamina alaris" RELATED LATIN [Wikipedia:Alar_plate] synonym: "lamina dorsolateralis" RELATED LATIN [Wikipedia:Alar_plate] synonym: "sensory part of neural tube" RELATED [] -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1370 +xref: neuronames:1370 xref: Wikipedia:Alar_plate is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure @@ -273139,7 +385110,11 @@ synonym: "celomic epithelium" EXACT [] synonym: "germinal epithelium of Waldeyer" EXACT [Wikipedia:Coelomic_epithelium] xref: Wikipedia:Coelomic_epithelium xref: XAO:0000329 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000483 ! epithelium +relationship: has_developmental_contribution_from UBERON:0004871 ! somatic layer of lateral plate mesoderm +relationship: has_developmental_contribution_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm +relationship: located_in UBERON:0002323 ! coelemic cavity lumen relationship: part_of UBERON:0011997 ! coelom property_value: UBPROP:0000012 "EHDAA2:0004049 used to be called 'coelomic epithelium' but is now 'gonadal ridge mesothelium'" xsd:string {external_ontology="EHDAA2"} @@ -273151,8 +385126,10 @@ def: "A bone that is part of the region of the hindlimb that includes the zeugop subset: grouping_class xref: EMAPA:37304 {source="MA:th"} xref: MA:0000670 -xref: MESH:A02.835.232.500 +xref: MESH:D007867 is_a: UBERON:0003464 ! hindlimb bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0000978 ! leg relationship: part_of UBERON:0000978 ! leg [Term] @@ -273173,6 +385150,8 @@ xref: MA:0000619 xref: SCTID:426741001 is_a: UBERON:0008962 ! forelimb bone is_a: UBERON:0011250 ! autopod bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0001442 ! skeleton of manus property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -273189,13 +385168,15 @@ synonym: "foot bone" EXACT [MA:0000643] xref: EMAPA:35354 xref: GAID:192 xref: MA:0000643 -xref: MESH:A02.835.232.300 +xref: MESH:D005529 xref: NCIT:C13068 xref: OpenCyc:Mx4rv5ridZwpEbGdrcN5Y29ycA xref: SCTID:361371005 xref: UMLS:C0016505 {source="ncithesaurus:Foot_Bone"} is_a: UBERON:0003464 ! hindlimb bone is_a: UBERON:0011250 ! autopod bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0001445 ! skeleton of pes property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -273213,6 +385194,7 @@ xref: BTO:0004675 xref: FMA:49187 xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2431 xref: http://www.snomedbrowser.com/Codes/Details/362618001 +xref: neuronames:2431 xref: SCTID:362618001 xref: TAO:0001414 xref: XAO:0003173 @@ -273223,6 +385205,18 @@ property_value: editor_note "TODO - check" xsd:string property_value: UBPROP:0000001 "An anatomical cluster that is located in the posterior region of the neurocranium and forms the margin of the foramen margin and occipital condyles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010199", ontology="AAO", source="AAO:EJS"} property_value: UBPROP:0000001 "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occiptal condyle.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001414", ontology="TAO", source="TAO:MAH"} +[Term] +id: UBERON:0005903 +name: duct of seminal vesicle +is_a: UBERON:0000025 ! tube +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005904 ! duct of male reproductive system +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0000998 ! seminal vesicle +relationship: channel_for UBERON:0010143 ! seminal vesicle fluid +relationship: channels_into UBERON:0000999 ! ejaculatory duct +relationship: part_of UBERON:0000998 ! seminal vesicle + [Term] id: UBERON:0005904 name: duct of male reproductive system @@ -273231,6 +385225,8 @@ def: "Any of the ducts that are part of a male reproductive system." [http://orc subset: grouping_class is_a: UBERON:0000058 ! duct is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0000079 ! male reproductive system property_value: IAO:0000232 "this class groups the individual ducts in a variety of species" xsd:string @@ -273264,6 +385260,7 @@ xref: FMA:20291 xref: SCTID:362531001 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005906 {source="FMA"} ! serous sac +relationship: adjacent_to UBERON:0001801 ! anterior segment of eyeball relationship: part_of UBERON:0000019 {source="FMA"} ! camera-type eye relationship: part_of UBERON:0035639 {source="HPO:pr"} ! ocular adnexa @@ -273287,7 +385284,6 @@ name: zone of bone organ namespace: uberon synonym: "bone organ zone" EXACT [FMA:10483] xref: FMA:10483 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034944 {source="FMA"} ! zone of organ relationship: composed_primarily_of UBERON:0002481 ! bone tissue @@ -273326,6 +385322,12 @@ xref: ZFA:0000550 is_a: UBERON:0000003 ! naris is_a: UBERON:0003102 {source="ZFA"} ! surface structure is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000003 ! naris +intersection_of: connects UBERON:0001707 ! nasal cavity +intersection_of: connects UBERON:0013514 ! space surrounding organism +relationship: capable_of_part_of GO:0007585 ! respiratory gaseous exchange by respiratory system +relationship: connects UBERON:0013514 ! space surrounding organism +relationship: contributes_to_morphology_of UBERON:0000004 ! nose relationship: part_of UBERON:0000004 ! nose property_value: UBPROP:0000001 "Hole on the nasal capsule that connects the nasal cavity with the exterior.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000024", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: subclass nasal opening (AAO:0000316)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000024", ontology="AAO"} @@ -273438,6 +385440,13 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8b/A property_value: seeAlso http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton xsd:anyURI property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"} +[Term] +id: UBERON:0005945 +name: neurocranial trabecula +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0003932 ! cartilage element of chondrocranium +relationship: part_of UBERON:0003112 ! olfactory region + [Term] id: UBERON:0005946 name: outflow tract of atrium @@ -273625,6 +385634,9 @@ subset: pheno_slim xref: EMAPA:37446 {source="MA:th"} is_a: UBERON:0001020 ! nervous system commissure is_a: UBERON:0007702 ! tract of brain +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: part_of UBERON:0000955 ! brain +relationship: BSPO:0005001 UBERON:0000955 ! brain property_value: UBPROP:0000001 "any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain[MP]" xsd:string {date_retrieved="2012-08-08", external_class="MP:0002199", ontology="MP"} [Term] @@ -273637,6 +385649,7 @@ synonym: "amnionic fold" EXACT [http://placentation.ucsd.edu/glossfs.html] xref: EMAPA:16076 is_a: UBERON:0000478 ! extraembryonic structure relationship: develops_from UBERON:0004874 {source="ISBN:0073040584"} ! somatopleure +relationship: only_in_taxon NCBITaxon:32524 ! Amniota [Term] id: UBERON:0005972 @@ -273661,9 +385674,9 @@ synonym: "cisterna magna" EXACT [MP:0009033] xref: EMAPA:37816 {source="MA:th"} xref: FMA:83721 xref: GAID:690 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=542 xref: MESH:D002946 xref: NCIT:C32324 +xref: neuronames:542 xref: SCTID:280391002 xref: UMLS:C0008841 {source="ncithesaurus:Cisterna_Magna"} xref: Wikipedia:Cisterna_magna @@ -273681,6 +385694,7 @@ synonym: "bulge of hair follicle" EXACT [FMA:70735] xref: BTO:0004904 xref: EMAPA:37876 {source="MA:th"} xref: FMA:70735 +is_a: UBERON:0010188 ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0019204 ! skin epithelium relationship: part_of UBERON:0002073 ! hair follicle @@ -273721,8 +385735,8 @@ xref: BAMS:SSL xref: EMAPA:37398 {source="MA:th"} xref: FMA:72524 xref: HBA:12938 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=667 xref: MBA:1056 +xref: neuronames:667 xref: NLXANAT:20081208 is_a: UBERON:0005348 ! ansiform lobule is_a: UBERON:0014648 ! hemisphere part of cerebellar posterior lobe @@ -273760,8 +385774,8 @@ xref: BAMS:ISL xref: EMAPA:37399 {source="MA:th"} xref: FMA:72525 xref: HBA:12939 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=668 xref: MBA:1064 +xref: neuronames:668 xref: NLXANAT:20081209 is_a: UBERON:0005348 ! ansiform lobule is_a: UBERON:0014648 ! hemisphere part of cerebellar posterior lobe @@ -273876,6 +385890,12 @@ def: "The layer of loose fibrous tissue located between the endocardium and myoc subset: pheno_slim xref: EMAPA:37968 {source="MA:th"} is_a: UBERON:0005983 ! heart layer +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: adjacent_to UBERON:0002165 ! endocardium +relationship: adjacent_to UBERON:0002349 ! myocardium +relationship: composed_primarily_of UBERON:0011824 ! fibrous connective tissue +relationship: has_part CL:0002068 ! Purkinje myocyte +relationship: has_part UBERON:0001021 ! nerve [Term] id: UBERON:0005985 @@ -273959,6 +385979,9 @@ xref: EMAPA:37432 {source="MA:th"} xref: ZFA:0005810 is_a: UBERON:0000440 ! trabecula is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0002302 ! myocardium of atrium +relationship: contributes_to_morphology_of UBERON:0002302 ! myocardium of atrium relationship: part_of UBERON:0002302 ! myocardium of atrium relationship: part_of UBERON:0004124 {source="ZFA"} ! myocardium trabecular layer @@ -273995,6 +386018,9 @@ synonym: "semilunar valvule of aortic valve" EXACT [FMA:7251] xref: FMA:7251 xref: SCTID:362026005 is_a: UBERON:0006009 ! cusp of cardiac valve +intersection_of: UBERON:0006009 ! cusp of cardiac valve +intersection_of: part_of UBERON:0002137 ! aortic valve +relationship: contributes_to_morphology_of UBERON:0002137 ! aortic valve relationship: part_of UBERON:0002137 ! aortic valve [Term] @@ -274011,6 +386037,9 @@ xref: EMAPA:37418 {source="MA:th"} xref: FMA:9502 is_a: UBERON:0006008 ! fibrous ring of heart is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0006008 ! fibrous ring of heart +intersection_of: part_of UBERON:0002137 ! aortic valve +relationship: contributes_to_morphology_of UBERON:0002137 ! aortic valve relationship: part_of UBERON:0002137 ! aortic valve [Term] @@ -274026,6 +386055,9 @@ synonym: "semilunar cusp of pulmonary valve" EXACT [FMA:7248] synonym: "semilunar valvule of pulmonary valve" EXACT [FMA:7248] xref: FMA:7248 is_a: UBERON:0006009 ! cusp of cardiac valve +intersection_of: UBERON:0006009 ! cusp of cardiac valve +intersection_of: part_of UBERON:0002146 ! pulmonary valve +relationship: contributes_to_morphology_of UBERON:0002146 ! pulmonary valve relationship: part_of UBERON:0002146 ! pulmonary valve [Term] @@ -274042,6 +386074,9 @@ xref: EMAPA:37420 {source="MA:th"} xref: FMA:9503 is_a: UBERON:0006008 ! fibrous ring of heart is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0006008 ! fibrous ring of heart +intersection_of: part_of UBERON:0002146 ! pulmonary valve +relationship: contributes_to_morphology_of UBERON:0002146 ! pulmonary valve relationship: part_of UBERON:0002146 ! pulmonary valve [Term] @@ -274060,8 +386095,11 @@ xref: NCIT:C32307 xref: SCTID:279330004 xref: UMLS:C0008484 {source="ncithesaurus:Chordae_Tendineae"} xref: Wikipedia:Chordae_tendineae +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0005983 ! heart layer is_a: UBERON:0010313 ! neural crest-derived structure +relationship: attaches_to UBERON:0005484 ! tricuspid valve leaflet +relationship: contributes_to_morphology_of UBERON:0002133 ! atrioventricular valve relationship: part_of UBERON:0002133 ! atrioventricular valve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png xsd:anyURI @@ -274079,8 +386117,14 @@ synonym: "mitral valvar anulus" EXACT [FMA:9498] xref: EMAPA:37419 {source="MA:th"} xref: FMA:9498 xref: Wikipedia:Mitral_annulus +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0006008 ! fibrous ring of heart is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0006008 ! fibrous ring of heart +intersection_of: attaches_to UBERON:0005996 ! mitral valve cusp +intersection_of: part_of UBERON:0002135 ! mitral valve +relationship: attaches_to UBERON:0005996 ! mitral valve cusp +relationship: contributes_to_morphology_of UBERON:0002135 ! mitral valve relationship: part_of UBERON:0002135 ! mitral valve [Term] @@ -274090,6 +386134,9 @@ namespace: uberon def: "The two fibrous components and associated flaps of the mitral valve." [MP:0010614] subset: pheno_slim is_a: UBERON:0006009 ! cusp of cardiac valve +intersection_of: UBERON:0006009 ! cusp of cardiac valve +intersection_of: part_of UBERON:0002135 ! mitral valve +relationship: contributes_to_morphology_of UBERON:0002135 ! mitral valve relationship: part_of UBERON:0002135 ! mitral valve [Term] @@ -274106,6 +386153,9 @@ xref: EMAPA:37421 {source="MA:th"} xref: FMA:9500 is_a: UBERON:0006008 ! fibrous ring of heart is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0006008 ! fibrous ring of heart +intersection_of: part_of UBERON:0002134 ! tricuspid valve +relationship: contributes_to_morphology_of UBERON:0002134 ! tricuspid valve relationship: part_of UBERON:0002134 ! tricuspid valve [Term] @@ -274118,13 +386168,16 @@ synonym: "cuspis septalis (valva tricuspidalis)" EXACT LATIN [FMA:7240, FMA:TA] synonym: "cuspis septalis valvae atrioventricularis dextrae" EXACT LATIN [FMA:7240, FMA:TA] synonym: "septal cusp of right atrioventricular valve" EXACT [FMA:7240] synonym: "septal cusp of tricuspid valve" EXACT [FMA:7240] -synonym: "septal leaflet of right-sided tricuspid valve" EXACT [BGEE:ANiknejad] +synonym: "septal leaflet of right-sided tricuspid valve" EXACT [https://orcid.org/0000-0003-3308-6245] synonym: "septal leaflet of tricuspid valve" EXACT [FMA:7240] synonym: "septal tricuspid leaflet" EXACT [FMA:7240] xref: FMA:7240 xref: SCTID:261417002 is_a: UBERON:0005484 {source="FMA"} ! tricuspid valve leaflet is_a: UBERON:0006009 ! cusp of cardiac valve +intersection_of: UBERON:0006009 ! cusp of cardiac valve +intersection_of: part_of UBERON:0002134 ! tricuspid valve +relationship: contributes_to_morphology_of UBERON:0002134 ! tricuspid valve property_value: editor_note "check whether we need to separate cusp/leaflet/valve" xsd:string [Term] @@ -274140,6 +386193,10 @@ xref: Wikipedia:Vitelline_arteries is_a: UBERON:0003513 ! trunk blood vessel is_a: UBERON:0004365 ! vitelline blood vessel is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001040 ! yolk sac +relationship: branching_part_of UBERON:0005805 {notes="ventral branch"} ! dorsal aorta +relationship: supplies UBERON:0001040 ! yolk sac property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png xsd:anyURI [Term] @@ -274247,6 +386304,8 @@ xref: Wikipedia:Fibrous_rings_of_heart is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0006444 ! annulus fibrosus +intersection_of: UBERON:0006444 ! annulus fibrosus +intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: editor_note "TODO - compare with ZFA atrioventricular ring, part of the conduction system" xsd:string @@ -274271,6 +386330,16 @@ is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0000946 ! cardial valve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png xsd:anyURI +[Term] +id: UBERON:0006010 +name: hyaloid canal +is_a: UBERON:0004111 ! anatomical conduit +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010313 ! neural crest-derived structure +relationship: develops_from UBERON:0002270 ! hyaloid artery +relationship: located_in UBERON:0001798 ! vitreous body +relationship: part_of UBERON:0001799 ! vitreous chamber of eyeball + [Term] id: UBERON:0006048 name: digit 1 @@ -274284,6 +386353,9 @@ synonym: "limb digit 1" EXACT [MA:0003023] xref: EMAPA:37285 {source="MA:th"} xref: MA:0003023 is_a: UBERON:0019221 ! digit 1 or 5 +intersection_of: UBERON:0002544 ! digit +intersection_of: part_of UBERON:5006048 ! digit 1 plus metapodial segment +relationship: BSPO:0001113 UBERON:0002470 ! autopod region relationship: part_of UBERON:5006048 ! digit 1 plus metapodial segment property_value: UBPROP:0000104 "1" xsd:nonNegativeInteger @@ -274342,6 +386414,8 @@ synonym: "limb digit 5" EXACT [] xref: EMAPA:17441 xref: EMAPA:37289 {source="MA:th"} is_a: UBERON:0019221 ! digit 1 or 5 +intersection_of: UBERON:0002544 ! digit +intersection_of: part_of UBERON:5006052 ! digit 5 plus metapodial segment relationship: part_of UBERON:5006052 ! digit 5 plus metapodial segment property_value: UBPROP:0000104 "5" xsd:nonNegativeInteger @@ -274362,6 +386436,7 @@ namespace: uberon def: "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." [https://orcid.org/0000-0002-6601-2165] subset: non_informative is_a: UBERON:0010758 ! subdivision of organism along appendicular axis +relationship: has_part UBERON:0002529 ! limb segment property_value: seeAlso https://github.com/obophenotype/uberon/issues/514 xsd:anyURI [Term] @@ -274373,8 +386448,8 @@ subset: pheno_slim synonym: "cerebral falx" EXACT [FMA:83967] xref: EMAPA:18551 xref: FMA:83967 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1237 xref: NCIT:C12890 +xref: neuronames:1237 xref: SCTID:279275004 xref: UMLS:C0228120 {source="ncithesaurus:Falx_Cerebri"} xref: Wikipedia:Falx_cerebri @@ -274450,6 +386525,7 @@ def: "One of the cartilaginous structures surrounding the embryonic spinal cord, synonym: "neural arch primordium" RELATED [] xref: BTO:0001763 is_a: UBERON:0010358 ! arch of centrum of vertebra +relationship: has_part UBERON:0002418 ! cartilage tissue relationship: part_of UBERON:0000922 ! embryo [Term] @@ -274463,6 +386539,8 @@ synonym: "muscle group of leg" EXACT [FMA:50211] synonym: "set of muscles of leg" EXACT [FMA:50211] xref: FMA:50211 is_a: UBERON:0004466 ! musculature of leg +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0003823 ! hindlimb zeugopod [Term] @@ -274476,6 +386554,8 @@ synonym: "tail vertebra" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:18042 xref: MA:0000696 is_a: UBERON:0001474 ! bone element +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0007812 ! post-anal tail relationship: part_of UBERON:0007812 ! post-anal tail property_value: UBPROP:0000012 "MA has distinct classes for 'tail bone', 'caudal vertebra' and 'coccygeal vertebra' but these may all be equivalent. This class may be obsoleted in future." xsd:string {external_ontology="MA"} @@ -274489,8 +386569,11 @@ synonym: "post-anal tail region" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "postsacral region" RELATED [AAO:0000082] synonym: "tail region" RELATED [AAO:0000082] xref: XAO:0000087 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: has_skeleton UBERON:0006076 ! caudal region of vertebral column relationship: part_of UBERON:0000154 ! posterior region of body +relationship: posterior_to UBERON:0001245 ! anus property_value: UBPROP:0000008 "This region is reduced in humans and corresponds to the coccyx" xsd:string property_value: UBPROP:0000012 "We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud" xsd:string {external_ontology="XAO"} @@ -274518,8 +386601,11 @@ xref: NCIT:C69313 xref: SCTID:260488005 xref: UMLS:C0728985 {source="ncithesaurus:Cervical_Spine"} is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0005434 ! cervical region relationship: part_of UBERON:0002090 ! postcranial axial skeleton relationship: part_of UBERON:0012477 {source="FMA"} ! dorsal part of neck +relationship: subdivision_of UBERON:0005434 ! cervical region property_value: UBPROP:0000001 "Anterior region of the vertebral column consisting of one to 19 or 20 vertebrae.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000092", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} [Term] @@ -274543,8 +386629,11 @@ xref: NCIT:C69315 xref: SCTID:243931006 xref: UMLS:C0581269 {source="ncithesaurus:Thoracic_Spine"} is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0000915 ! thoracic segment of trunk relationship: part_of UBERON:0008231 {source="FMA"} ! dorsal thoracic segment of trunk relationship: part_of UBERON:0014477 ! thoracic skeleton +relationship: subdivision_of UBERON:0000915 ! thoracic segment of trunk property_value: UBPROP:0000001 "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000612", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} [Term] @@ -274568,8 +386657,11 @@ xref: MA:0003156 xref: NCIT:C69314 xref: SCTID:243932004 is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0005462 ! lower back relationship: part_of UBERON:0002090 ! postcranial axial skeleton relationship: part_of UBERON:0005462 ! lower back +relationship: subdivision_of UBERON:0005462 ! lower back property_value: UBPROP:0000007 "lumbar" xsd:string [Term] @@ -274590,8 +386682,11 @@ xref: MA:0003157 xref: NCIT:C33508 xref: Wikipedia:Sacrum is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0005473 ! sacral region relationship: part_of UBERON:0002090 ! postcranial axial skeleton relationship: part_of UBERON:0005473 ! sacral region +relationship: subdivision_of UBERON:0005473 ! sacral region property_value: UBPROP:0000001 "Region of the vertebral column represented by one or two vertebrae.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000724", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} property_value: UBPROP:0000008 "In adult humans, the sacral skeleton is fused and called the sacrum" xsd:string @@ -274610,8 +386705,11 @@ xref: AAO:0000082 xref: EMAPA:18043 xref: MA:0003158 is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0006071 ! caudal region relationship: part_of UBERON:0002090 ! postcranial axial skeleton relationship: part_of UBERON:0006071 ! caudal region +relationship: subdivision_of UBERON:0006071 ! caudal region property_value: UBPROP:0000001 "Region of the vertebral column posterior to the caudal-sacral region, that may consists of two or three to more than 100 vertebrae. These vertebrae exhibit a gradual reduction in the sizes of their transverse processes and zygapophyses, but these structures are never entirely absent. All caudal vertebrae bear haemal arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000082", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} property_value: UBPROP:0000012 "in AAO, this is posterior to the caudal-sacral region" xsd:string {external_ontology="AAO"} @@ -274630,14 +386728,18 @@ synonym: "vertebral subdivision" RELATED [] xref: FMA:16201 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: subdivision_of UBERON:0001130 ! vertebral column relationship: part_of UBERON:0001130 ! vertebral column relationship: part_of UBERON:0001137 {source="FMA"} ! dorsum +relationship: subdivision_of UBERON:0001130 ! vertebral column [Term] id: UBERON:0006082 name: fundus of urinary bladder namespace: uberon def: "The base or posterior surface of the urinary bladder contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice." [MP:0011785, Wikipedia:Fundus_of_the_urinary_bladder#Fundus] +subset: human_reference_atlas subset: pheno_slim synonym: "base of urinary bladder" EXACT [FMA:15908] synonym: "bladder dome" RELATED [EMAPA:35173] @@ -274659,9 +386761,11 @@ xref: VHOG:0001184 xref: Wikipedia:Fundus_of_the_urinary_bladder#Fundus is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: develops_from UBERON:0005760 {source="EHDAA2-modified"} ! urorectal septum relationship: develops_from UBERON:0009845 {source="EHDAA2"} ! urogenital sinus mesenchyme relationship: part_of UBERON:0001255 ! urinary bladder +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006098 @@ -274678,7 +386782,7 @@ xref: BAMS:BG xref: BAMS:BNC xref: BIRNLEX:1629 xref: EV:0100182 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 {source="BIRNLEX:1629"} +xref: neuronames:224 {source="BIRNLEX:1629"} xref: UMLS:C0004781 {source="BIRNLEX:1629"} is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019264 ! gray matter of forebrain @@ -274712,8 +386816,10 @@ def: "A funiculus of neuraxis that is part of a spinal cord." [OBOL:automatic] synonym: "spinal cord funiculus" EXACT [FMA:77460] synonym: "white column of spinal cord" EXACT [FMA:77460] xref: FMA:77460 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2760 +xref: neuronames:2760 is_a: UBERON:0006133 ! funiculus of neuraxis +intersection_of: UBERON:0006133 ! funiculus of neuraxis +intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002318 ! white matter of spinal cord [Term] @@ -274732,6 +386838,7 @@ id: UBERON:0006134 name: nerve fiber namespace: uberon def: "A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system." [Wikipedia:Nervous_system_fiber] +subset: human_reference_atlas synonym: "nerve fibers" RELATED PLURAL [BAMS:nfi] synonym: "nerve fibre" EXACT [FMA:5914] synonym: "neurofibra" EXACT LATIN [FMA:5914, FMA:TA] @@ -274739,7 +386846,7 @@ synonym: "neurofibra" RELATED LATIN [Wikipedia:Nerve_fiber] synonym: "neurofibrum" EXACT [FMA:5914] xref: BAMS:nfi xref: FMA:5914 -xref: MESH:A08.663.542 +xref: MESH:D009412 xref: SCTID:88545005 xref: Wikipedia:Nervous_system_fiber is_a: CARO:0000000 ! anatomical entity @@ -274749,6 +386856,7 @@ union_of: UBERON:0006136 ! unmyelinated nerve fiber relationship: extends_fibers_into CL:0000540 ! neuron relationship: has_part GO:0030424 ! axon relationship: part_of UBERON:0001019 ! nerve fasciculus +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "neurofibrous" xsd:string [Term] @@ -274759,7 +386867,7 @@ def: "Axons of neurons encased in a lipoproteinaceous material called myelin. (M subset: pheno_slim xref: FMA:5915 xref: GAID:745 -xref: MESH:A08.663.542.512 +xref: MESH:D009413 xref: NCIT:C12627 xref: SCTID:362296008 xref: UMLS:C0027750 {source="ncithesaurus:Myelinated_Nerve_Fiber"} @@ -274779,14 +386887,16 @@ property_value: UBPROP:0000008 "http://www1.pbrc.hawaii.edu/~danh/MyelinEvolutio id: UBERON:0006136 name: unmyelinated nerve fiber namespace: uberon +subset: human_reference_atlas synonym: "non-myelinated nerve fiber" EXACT [FMA:5916] xref: FMA:5916 xref: GAID:767 -xref: MESH:A08.663.542.756 +xref: MESH:D036421 xref: NCIT:C33835 xref: SCTID:46920005 xref: UMLS:C0501409 {source="ncithesaurus:Unmyelinated_Nerve_Fiber"} is_a: UBERON:0006134 ! nerve fiber +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006170 @@ -274799,6 +386909,49 @@ intersection_of: UBERON:0002015 ! kidney capsule intersection_of: part_of UBERON:0000080 ! mesonephros relationship: part_of UBERON:0000080 ! mesonephros +[Term] +id: UBERON:0006173 +name: pronephric proximal tubule +is_a: UBERON:0004134 ! proximal tubule +is_a: UBERON:0005310 ! pronephric nephron tubule +intersection_of: UBERON:0004134 ! proximal tubule +intersection_of: part_of UBERON:0002120 ! pronephros + +[Term] +id: UBERON:0006175 +name: pronephric distal tubule +is_a: UBERON:0004135 ! distal tubule +is_a: UBERON:0005310 ! pronephric nephron tubule +intersection_of: UBERON:0004135 ! distal tubule +intersection_of: part_of UBERON:0002120 ! pronephros + +[Term] +id: UBERON:0006183 +name: mesonephric glomerular capillary +is_a: UBERON:0004212 ! glomerular capillary +intersection_of: UBERON:0004212 ! glomerular capillary +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0005322 ! mesonephric nephron +relationship: part_of UBERON:0005325 ! mesonephric glomerulus + +[Term] +id: UBERON:0006190 +name: mesonephric distal tubule +is_a: UBERON:0000083 ! mesonephric tubule +is_a: UBERON:0004135 ! distal tubule +is_a: UBERON:0005330 ! mesonephric nephron epithelium +intersection_of: UBERON:0004135 ! distal tubule +intersection_of: part_of UBERON:0000080 ! mesonephros + +[Term] +id: UBERON:0006192 +name: mesonephric proximal tubule +is_a: UBERON:0000083 ! mesonephric tubule +is_a: UBERON:0004134 ! proximal tubule +is_a: UBERON:0005330 ! mesonephric nephron epithelium +intersection_of: UBERON:0004134 ! proximal tubule +intersection_of: part_of UBERON:0000080 ! mesonephros + [Term] id: UBERON:0006206 name: iridocorneal angle @@ -274856,7 +387009,6 @@ xref: EHDAA:4685 xref: EMAPA:17280 xref: NCIT:C34110 xref: VHOG:0001364 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0001691 ! external ear @@ -274935,7 +387087,10 @@ is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010377 ! mesenchyme from somatopleure is_a: UBERON:0015049 ! carpus endochondral element +intersection_of: UBERON:0005863 ! cartilaginous condensation +intersection_of: has_potential_to_develop_into UBERON:0001435 ! carpal bone relationship: develops_from UBERON:0006214 ! carpus pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001435 ! carpal bone [Term] id: UBERON:0006214 @@ -274952,7 +387107,10 @@ is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0009523 ! mesenchyme of handplate is_a: UBERON:0015049 ! carpus endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001435 ! carpal bone relationship: develops_from UBERON:0003319 ! mesenchyme of carpal region +relationship: has_potential_to_develop_into UBERON:0001435 ! carpal bone [Term] id: UBERON:0006215 @@ -274978,6 +387136,9 @@ xref: XAO:0004135 xref: ZFA:0001440 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0002037 ! cerebellum +relationship: has_potential_to_develop_into UBERON:0002037 ! cerebellum relationship: part_of UBERON:0010092 {source="EHDAA2", source="Wikipedia"} ! future metencephalon property_value: UBPROP:0000001 "The interface between the dorsal neuroepithelium and the roofplate of the fourth ventricle. The source of a number of migratory neuron populations of the hindbrain.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001440", ontology="TAO", source="ZFIN:curator"} @@ -275098,6 +387259,7 @@ xref: EHDAA:8483 xref: EMAPA:17710 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001048 ! primordium +relationship: has_potential_to_develop_into UBERON:0001490 ! elbow joint relationship: part_of UBERON:0003318 ! mesenchyme of elbow [Term] @@ -275110,6 +387272,7 @@ xref: EMAPA:16994 xref: MA:0000241 xref: VHOG:0000373 is_a: UBERON:0006598 ! presumptive structure +relationship: has_potential_to_develop_into UBERON:0001860 ! endolymphatic duct property_value: UBPROP:0000001 "An outgrowth of the otic vesicle that forms the endolymphatic duct and sac during embryonic development. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000373", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/endolymphatic+appendage"} [Term] @@ -275123,7 +387286,10 @@ xref: EMAPA:18023 xref: FMA:312597 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001679 ! ethmoid bone relationship: develops_from UBERON:0007213 {source="EHDAA2"} ! mesenchyme derived from head neural crest +relationship: has_potential_to_develop_into UBERON:0001679 ! ethmoid bone relationship: part_of UBERON:0002517 {source="FMA"} ! basicranium relationship: part_of UBERON:0011241 {source="AAO"} ! ethmoid region property_value: editor_note "consider obsoleting, the ethmoid is endochondral?" xsd:string @@ -275183,6 +387349,8 @@ xref: EMAPA:18680 xref: RETIRED_EHDAA2:0000500 xref: VHOG:0000666 is_a: UBERON:0011757 ! differentiated genital tubercle +intersection_of: UBERON:0011757 ! differentiated genital tubercle +intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: part_of UBERON:0005056 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! external female genitalia [Term] @@ -275199,6 +387367,9 @@ is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015052 ! femur endochondral element +intersection_of: UBERON:0015052 ! femur endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0000981 ! femur [Term] id: UBERON:0006235 @@ -275212,6 +387383,12 @@ xref: EMAPA:16363 xref: VHOG:0000291 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0001041 ! foregut +intersection_of: connects UBERON:0001045 ! midgut +relationship: connects UBERON:0001041 ! foregut +relationship: connects UBERON:0001045 ! midgut relationship: part_of UBERON:0001555 ! digestive tract property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000291", ontology="VHOG", source="http://bgee.unil.ch/", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11"} property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000291", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} @@ -275327,7 +387504,10 @@ xref: EMAPA:16713 xref: XAO:0004205 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0002110 ! gall bladder relationship: develops_from UBERON:0001152 {source="EHDAA2"} ! cystic duct +relationship: has_potential_to_develop_into UBERON:0002110 ! gall bladder relationship: part_of UBERON:0001173 {source="cjm"} ! biliary tree relationship: part_of UBERON:0004912 {source="EMAPA"} ! biliary bud @@ -275357,7 +387537,10 @@ is_a: UBERON:0005258 ! upper arm mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015053 ! humerus endochondral element +intersection_of: UBERON:0015053 ! humerus endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006246 {source="EHDAA2"} ! humerus pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0000976 ! humerus [Term] id: UBERON:0006246 @@ -275374,6 +387557,9 @@ is_a: UBERON:0005258 ! upper arm mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015053 ! humerus endochondral element +intersection_of: UBERON:0015053 ! humerus endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0000976 ! humerus [Term] id: UBERON:0006247 @@ -275389,6 +387575,9 @@ is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010377 ! mesenchyme from somatopleure is_a: UBERON:0015054 ! iliac endochondral element +intersection_of: UBERON:0015054 ! iliac endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: develops_from UBERON:0006210 {source="EHDAA2"} ! body-wall mesenchyme [Term] @@ -275426,7 +387615,7 @@ xref: EHDAA:4479 xref: EMAPA:16899 xref: EMAPA_RETIRED:16648 xref: FMA:78456 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=458 +xref: neuronames:458 xref: SCTID:369280006 xref: Wikipedia:Infundibular_recess is_a: UBERON:0002050 ! embryonic structure @@ -275464,6 +387653,8 @@ xref: EMAPA:26930 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015056 ! ischial endochondral element +intersection_of: UBERON:0015056 ! ischial endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006255 {source="EHDAA2"} ! ischial pre-cartilage condensation [Term] @@ -275480,6 +387671,9 @@ is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0010377 ! mesenchyme from somatopleure is_a: UBERON:0015056 ! ischial endochondral element +intersection_of: UBERON:0015056 ! ischial endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0006256 @@ -275491,6 +387685,7 @@ xref: EHDAA:8467 xref: EMAPA:17740 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +relationship: has_potential_to_develop_into UBERON:0001485 ! knee joint relationship: part_of UBERON:0003321 ! mesenchyme of knee [Term] @@ -275524,6 +387719,8 @@ xref: EMAPA:17969 xref: RETIRED_EHDAA2:0001048 xref: VHOG:0000667 is_a: UBERON:0011757 ! differentiated genital tubercle +intersection_of: UBERON:0011757 ! differentiated genital tubercle +intersection_of: part_of UBERON:0000079 ! male reproductive system relationship: part_of UBERON:0004053 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! external male genitalia [Term] @@ -275612,6 +387809,8 @@ is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0019306 ! nose epithelium +relationship: adjacent_to UBERON:0004067 ! lateral nasal prominence +relationship: adjacent_to UBERON:0005868 ! maxillary prominence relationship: develops_from UBERON:0012313 {source="EHDAA2"} ! 1st arch maxillary ectoderm relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray163.png xsd:anyURI @@ -275661,6 +387860,24 @@ is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0000924 {source="EHDAA2"} ! ectoderm relationship: only_in_taxon NCBITaxon:7711 ! Chordata +[Term] +id: UBERON:0006271 +name: orbital fissure +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: part_of UBERON:0001697 ! orbit of skull +relationship: part_of UBERON:0001697 ! orbit of skull + +[Term] +id: UBERON:0006272 +name: oronasal cavity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +relationship: developmentally_replaces UBERON:0009672 ! oronasal membrane +relationship: part_of UBERON:0000166 ! oral opening +relationship: part_of UBERON:0000922 ! embryo + [Term] id: UBERON:0006273 name: otic pit @@ -275679,6 +387896,7 @@ xref: VHOG:0001147 xref: Wikipedia:Otic_pit is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0016566 {source="EHDAA2"} ! pit +relationship: has_potential_to_develop_into UBERON:0003051 ! ear vesicle relationship: part_of UBERON:0003069 ! otic placode property_value: UBPROP:0000001 "A depression appearing in each otic placode, marking the beginnning of embryonic development of the internal ear. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001147", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Otic+pit"} @@ -275813,6 +388031,9 @@ is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0010377 ! mesenchyme from somatopleure is_a: UBERON:0015055 ! pubic endochondral element +intersection_of: UBERON:0015055 ! pubic endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0006286 @@ -275825,6 +388046,8 @@ xref: EMAPA:18054 xref: VHOG:0001318 is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015001 ! radius endochondral element +intersection_of: UBERON:0015001 ! radius endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010846 ! radius pre-cartilage condensation relationship: part_of UBERON:0003327 {source="EHDAA2"} ! mesenchyme of forearm @@ -275841,6 +388064,8 @@ is_a: UBERON:0003327 ! mesenchyme of forearm is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation property_value: UBPROP:0000012 "EMAPA has a separate radius-ulna cartilage condensation." xsd:string {external_ontology="EMAPA"} [Term] @@ -275856,7 +388081,10 @@ xref: VHOG:0001122 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015019 ! rib endochondral element +intersection_of: UBERON:0015019 ! rib endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006289 {source="EHDAA2"} ! rib pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002228 ! rib [Term] id: UBERON:0006289 @@ -275870,7 +388098,11 @@ xref: EMAPA:17397 xref: VHOG:0000681 is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0015019 ! rib endochondral element +intersection_of: UBERON:0015019 ! rib endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: develops_from UBERON:0003089 {source="EHDAA2-abduced", source="ZFA"} ! sclerotome +relationship: has_potential_to_develop_into UBERON:0002228 ! rib [Term] id: UBERON:0006290 @@ -275884,7 +388116,10 @@ xref: EMAPA:18343 xref: VHOG:0001125 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015057 ! scapula endochondral element +intersection_of: UBERON:0015057 ! scapula endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006291 {source="EHDAA2"} ! scapula pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0006849 ! scapula relationship: part_of UBERON:0000922 ! embryo [Term] @@ -275899,7 +388134,11 @@ xref: EMAPA:18027 xref: VHOG:0000960 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0015057 ! scapula endochondral element +intersection_of: UBERON:0015057 ! scapula endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: develops_from UBERON:0006210 {source="EHDAA2"} ! body-wall mesenchyme +relationship: has_potential_to_develop_into UBERON:0006849 ! scapula property_value: UBPROP:0000011 "the scapula has been shown to develop from multiple tissues, such as the dermomyotome of the somites, the mesodermal portion of the soma- topleure (a domain of the lateral plate mesoderm or LPM) and neural crest cell-derived mesenchyme (Huang et al., 2000; Matsuoka et al., 2005; Wang et al., 2005)." xsd:string {source="PMID:21455939"} [Term] @@ -275913,6 +388152,7 @@ xref: EMAPA:17712 is_a: UBERON:0003322 ! mesenchyme of shoulder is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation relationship: develops_from UBERON:0003322 {source="EHDAA2"} ! mesenchyme of shoulder +relationship: has_potential_to_develop_into UBERON:0001470 ! glenohumeral joint property_value: UBPROP:0000012 "this is part of the forelimb skeleton in EHDAA2, but this violates part-disjointness" xsd:string {external_ontology="EHDAA2"} [Term] @@ -275980,6 +388220,9 @@ xref: EHDAA2:0001935 xref: EHDAA:7989 xref: EMAPA:17752 is_a: UBERON:0017651 ! salivary gland primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001832 ! sublingual gland +relationship: has_potential_to_develop_into UBERON:0001832 ! sublingual gland [Term] id: UBERON:0006298 @@ -275992,6 +388235,11 @@ xref: EHDAA2:0001939 xref: EHDAA:9255 xref: EMAPA:17755 is_a: UBERON:0017651 ! salivary gland primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001736 ! submandibular gland +relationship: has_developmental_contribution_from UBERON:0002424 ! oral epithelium +relationship: has_developmental_contribution_from UBERON:0006905 ! mandibular process mesenchyme +relationship: has_potential_to_develop_into UBERON:0001736 ! submandibular gland relationship: part_of UBERON:0001710 ! lower jaw region [Term] @@ -276037,6 +388285,8 @@ xref: VHOG:0001155 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015003 ! ulna endochondral element +intersection_of: UBERON:0015003 ! ulna endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010847 ! ulna pre-cartilage condensation relationship: part_of UBERON:0003327 ! mesenchyme of forearm @@ -276098,6 +388348,7 @@ is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: has_quality PATO:0001548 ! quality of a liquid relationship: has_quality PATO:0001548 ! quality of a liquid +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl [Term] id: UBERON:0006320 @@ -276130,6 +388381,15 @@ is_a: UBERON:0006532 {source="MA"} ! oblique extraocular muscle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e8/Eyemuscles.png xsd:anyURI property_value: UBPROP:0000003 "The ability to rotate the eyeball is common to all vertebrates with well-developed eyes, regardless of the habitat in which they live, so these [extrinsic ocular] muscles tend to be conservative. They change little during the course of evolution.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001132", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.331", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0006321 +name: superior oblique extraocular muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0006532 ! oblique extraocular muscle +relationship: has_muscle_insertion UBERON:0010230 ! eyeball of camera-type eye +relationship: has_muscle_origin UBERON:0014796 ! common tendinous ring +relationship: innervated_by UBERON:0001644 ! trochlear nerve + [Term] id: UBERON:0006322 name: inferior rectus extraocular muscle @@ -276275,13 +388535,41 @@ xref: Wikipedia:Snout xref: ZFA:0005496 is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0004089 ! midface +property_value: RO:0002161 NCBITaxon:9606 property_value: UBPROP:0000001 "Surface structure that is the region of the head in front of and between the orbits, and above the lower jaw. Nares are located on the snout[ZFA]." xsd:string {date_retrieved="2012-10-05", ontology="ZFA", ontology_class="ZFA:0005496"} +[Term] +id: UBERON:0006338 +name: lateral ventricle choroid plexus stroma +is_a: UBERON:0005206 ! choroid plexus stroma +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0005206 ! choroid plexus stroma +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle +relationship: part_of UBERON:0002307 ! choroid plexus of lateral ventricle + +[Term] +id: UBERON:0006339 +name: third ventricle choroid plexus stroma +is_a: UBERON:0005206 ! choroid plexus stroma +intersection_of: UBERON:0005206 ! choroid plexus stroma +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002288 ! choroid plexus of third ventricle + +[Term] +id: UBERON:0006340 +name: fourth ventricle choroid plexus stroma +is_a: UBERON:0005206 ! choroid plexus stroma +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0005206 ! choroid plexus stroma +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002290 ! choroid plexus of fourth ventricle + [Term] id: UBERON:0006345 name: stapedial artery namespace: uberon def: "A small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood[MP]." [MP:0004665] +subset: human_reference_atlas subset: pheno_slim synonym: "stapedial" RELATED [EHDAA2:0001908] synonym: "stapedial artery temporary" EXACT [EHDAA2:0001908] @@ -276298,6 +388586,7 @@ is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: develops_from UBERON:0003119 {source="EHDAA2"} ! pharyngeal arch artery 2 relationship: part_of UBERON:0001756 {source="EHDAA2"} ! middle ear +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006347 @@ -276451,6 +388740,9 @@ xref: SCTID:27962002 xref: Wikipedia:Baculum is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007719 ! bone of reproductive organ +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0000989 ! penis +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0000989 ! penis property_value: RO:0002161 NCBITaxon:9606 property_value: UBPROP:0000008 "found in most mammals, with the exception of humans" xsd:string @@ -276469,7 +388761,13 @@ xref: EMAPA:30823 xref: MA:0000387 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007719 ! bone of reproductive organ +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system +relationship: contributes_to_morphology_of UBERON:0002411 ! clitoris +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia relationship: part_of UBERON:0002411 ! clitoris +relationship: sexually_homologous_to UBERON:0006435 ! os penis property_value: RO:0002161 NCBITaxon:9606 [Term] @@ -276485,6 +388783,7 @@ synonym: "fibrous ring" RELATED [BTO:0003627] xref: BTO:0003627 xref: EMAPA:32670 xref: FMA:76704 +xref: MESH:D000070616 is_a: UBERON:0001995 ! fibrocartilage [Term] @@ -276525,9 +388824,9 @@ synonym: "pallidum of neuraxis" EXACT [FMA:83684] xref: BAMS:PAL xref: EMAPA:32780 xref: FMA:83684 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2673 xref: MA:0000889 xref: MBA:803 +xref: neuronames:2673 is_a: UBERON:0003528 ! brain gray matter relationship: part_of UBERON:0002420 {source="MA"} ! basal ganglion property_value: RO:0002171 UBERON:0002435 {source="ABA"} @@ -276537,6 +388836,7 @@ id: UBERON:0006517 name: kidney calyx namespace: uberon def: "Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211)." [MESH:A05.810.453.537.503] +subset: human_reference_atlas subset: pheno_slim synonym: "calices renales" EXACT LATIN [] synonym: "calices renales" RELATED PLURAL [] @@ -276554,6 +388854,7 @@ xref: UMLS:C0022651 {source="ncithesaurus:Renal_Calyx"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000063 ! organ subunit relationship: part_of UBERON:0001224 ! renal pelvis +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "calyceal" xsd:string [Term] @@ -276569,6 +388870,8 @@ xref: NCIT:C48944 xref: SCTID:272654004 xref: UMLS:C1285106 {source="ncithesaurus:Lobe_of_the_Right_Lung"} is_a: UBERON:0000101 ! lobe of lung +intersection_of: UBERON:0000101 ! lobe of lung +intersection_of: part_of UBERON:0002167 ! right lung relationship: part_of UBERON:0002167 ! right lung property_value: UBPROP:0000008 "4 in mice, divided into 3 in human by two interlobal fissures" xsd:string {source="ISBN:0123813611"} @@ -276586,8 +388889,25 @@ xref: EMAPA:32692 xref: MA:0000416 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision +relationship: contributes_to_morphology_of UBERON:0002048 ! lung relationship: part_of UBERON:0002048 ! lung +[Term] +id: UBERON:0006525 +name: left lung alveolar system +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011216 ! organ system subdivision +relationship: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0006524 ! alveolar system + +[Term] +id: UBERON:0006526 +name: right lung alveolar system +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011216 ! organ system subdivision +relationship: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0006524 ! alveolar system + [Term] id: UBERON:0006530 name: seminal fluid @@ -276606,6 +388926,11 @@ xref: MAT:0000057 xref: MIAA:0000057 is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006536 ! male reproductive gland secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: part_of UBERON:0001968 ! semen +intersection_of: produced_by UBERON:0005399 ! male reproductive gland +relationship: capable_of_part_of GO:0048240 ! sperm capacitation +relationship: capable_of_part_of GO:1902093 ! positive regulation of flagellated sperm motility relationship: part_of UBERON:0001968 ! semen property_value: IAO:0000232 "this ontology contains a number of subtypes of seminal fluid, defined according to glands (which are more taxonomically restricted)" xsd:string property_value: IAO:0000232 "we follow FMA and make this class a generic superclass of the secretions of different glands (prostate, bulbo-urethreal, seminal vesicle). MA (and ncit) follows a mixture model, where these secretions are part of the seminal fluid" xsd:string @@ -276667,7 +388992,6 @@ synonym: "skin fluid" RELATED [] synonym: "skin fluid/secretion" EXACT [MA:0002537] synonym: "skin substance" RELATED [] xref: MA:0002537 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0000014 ! zone of skin @@ -276684,6 +389008,9 @@ synonym: "male reproductive system secretion" RELATED [] xref: EMAPA:36541 xref: MA:0002521 is_a: UBERON:0022293 ! reproductive gland secretion +intersection_of: UBERON:0000463 ! organism substance +intersection_of: produced_by UBERON:0005399 ! male reproductive gland +relationship: produced_by UBERON:0005399 ! male reproductive gland [Term] id: UBERON:0006537 @@ -276711,7 +389038,6 @@ xref: http://linkedlifedata.com/resource/umls/id/C1514899 xref: MA:0002533 xref: NCIT:C13722 xref: UMLS:C1514899 {source="ncithesaurus:Respiratory_System_Fluid_or_Secretion"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0001004 ! respiratory system @@ -276731,12 +389057,24 @@ synonym: "secretion of mammary gland" RELATED [] xref: EMAPA:36538 xref: MA:0002505 is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000463 ! organism substance +intersection_of: produced_by UBERON:0001911 ! mammary gland +relationship: produced_by UBERON:0001911 ! mammary gland + +[Term] +id: UBERON:0006542 +name: outer medulla outer stripe loop of Henle +is_a: UBERON:0034996 ! outer renal medulla loop of Henle +intersection_of: UBERON:0001288 ! loop of Henle +intersection_of: part_of UBERON:0004202 ! kidney outer medulla outer stripe +relationship: part_of UBERON:0004202 ! kidney outer medulla outer stripe [Term] id: UBERON:0006544 name: kidney vasculature namespace: uberon def: "A vasculature that is part of a kidney." [OBOL:automatic] +subset: human_reference_atlas subset: vertebrate_core xref: EMAPA:28457 xref: TAO:0005305 @@ -276747,6 +389085,7 @@ is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006553 @@ -276821,6 +389160,7 @@ synonym: "anterior part of foregut" RELATED [] synonym: "pharyngeal tube" RELATED [] xref: FBbt:00005380 xref: MAT:0000049 +xref: MESH:D010614 xref: MIAA:0000049 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: only_in_taxon NCBITaxon:33213 ! Bilateria @@ -276839,11 +389179,20 @@ intersection_of: UBERON:0002522 ! tunica media intersection_of: part_of UBERON:0002333 ! pulmonary trunk relationship: part_of UBERON:0002333 ! pulmonary trunk +[Term] +id: UBERON:0006565 +name: female urethral meatus +is_a: UBERON:0012240 ! urethral meatus +intersection_of: UBERON:0012240 ! urethral meatus +intersection_of: part_of UBERON:0003100 ! female organism +relationship: part_of UBERON:0001334 ! female urethra + [Term] id: UBERON:0006566 name: left ventricle myocardium namespace: uberon def: "A myocardium that is part of a left ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas synonym: "left ventricular myocardium" EXACT [FMA:9558] synonym: "myocardium of left ventricle" EXACT [FMA:9558] xref: EMAPA:17339 @@ -276855,6 +389204,7 @@ intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: continuous_with UBERON:0003618 ! aorta tunica media relationship: part_of UBERON:0002084 ! heart left ventricle +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Myocardium of ventricle which is continuous with the tunica media of aorta." xsd:string {source="FMA:9558"} [Term] @@ -276862,6 +389212,7 @@ id: UBERON:0006567 name: right ventricle myocardium namespace: uberon def: "A myocardium that is part of a right ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas subset: pheno_slim synonym: "myocardium of right ventricle" EXACT [FMA:9535] synonym: "right ventricular myocardium" EXACT [FMA:9535] @@ -276874,6 +389225,7 @@ intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: continuous_with UBERON:0006563 ! tunica media of pulmonary trunk relationship: part_of UBERON:0002080 ! heart right ventricle +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk." xsd:string {source="FMA:9535"} [Term] @@ -276888,6 +389240,8 @@ xref: FMA:258762 xref: MA:0002426 xref: SCTID:279304003 is_a: UBERON:0006569 ! diencephalic nucleus +intersection_of: UBERON:0002308 ! nucleus of brain +intersection_of: part_of UBERON:0001898 ! hypothalamus relationship: part_of UBERON:0001898 ! hypothalamus [Term] @@ -276907,12 +389261,16 @@ id: UBERON:0006574 name: pectinate line namespace: uberon def: "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:" [http://en.wikipedia.org/wiki/Pectinate_line] +def: "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." [Wikipedia:Pectinate_line] +synonym: "dentate line" RELATED [Wikipedia:Pectinate_line] synonym: "dentate line" RELATED [http://en.wikipedia.org/wiki/Pectinate_line] synonym: "Hilton's 'white line'" RELATED [EMAPA:19159] +synonym: "linea anocutanea" RELATED LATIN [Wikipedia:Pectinate_line] synonym: "linea anocutanea" RELATED LATIN [http://en.wikipedia.org/wiki/Pectinate_line] synonym: "linea pectinata canalis analis" EXACT LATIN [FMA:75383, FMA:TA] synonym: "pectinate line of anal canal" EXACT [FMA:75383] synonym: "recto-anal junction" RELATED [http://en.wikipedia.org/wiki/Pectinate_line] +synonym: "recto-anal junction" RELATED [Wikipedia:Pectinate_line] synonym: "site of anal membrane" RELATED [EMAPA:19159] xref: EMAPA:19159 xref: FMA:75383 @@ -276920,14 +389278,21 @@ xref: http://linkedlifedata.com/resource/umls/id/C0821671 xref: http://www.snomedbrowser.com/Codes/Details/245445008 xref: NCIT:C34245 xref: Pectinate:line +xref: SCTID:245445008 xref: UMLS:C0821671 {source="ncithesaurus:Pectinate_Line"} +xref: Wikipedia:Pectinate_line is_a: UBERON:0004121 ! ectoderm-derived structure -is_a: UBERON:0007651 ! anatomical junction +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: adjacent_to UBERON:0000931 ! proctodeum intersection_of: adjacent_to UBERON:0001046 ! hindgut +intersection_of: connects UBERON:0000931 ! proctodeum +intersection_of: connects UBERON:0001046 ! hindgut relationship: adjacent_to UBERON:0000931 ! proctodeum relationship: adjacent_to UBERON:0001046 ! hindgut +relationship: connects UBERON:0000931 ! proctodeum +relationship: connects UBERON:0001046 ! hindgut relationship: part_of UBERON:0000159 ! anal canal property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png xsd:anyURI property_value: UBPROP:0000012 "FMA also has FMA:29321 but it's not clear how this differs" xsd:string {external_ontology="FMA"} @@ -276942,6 +389307,8 @@ xref: BIRNLEX:2519 xref: UMLS:C0682674 {source="BIRNLEX:2519"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000062 ! organ +intersection_of: UBERON:0000062 ! organ +intersection_of: part_of UBERON:0004681 ! vestibular system relationship: part_of UBERON:0000012 {source="NIFSTD"} ! somatic nervous system relationship: part_of UBERON:0004681 ! vestibular system @@ -276955,7 +389322,7 @@ synonym: "labyrinthine fluid" RELATED [MESH:A12.207.571] xref: EMAPA:36547 xref: GAID:1183 xref: MA:0002527 -xref: MESH:A12.207.571 +xref: MESH:D007761 xref: NCIT:C33231 xref: UMLS:C1518679 {source="ncithesaurus:Otolymph"} is_a: UBERON:0007779 {source="FMA-abduced"} ! transudate @@ -277124,12 +389491,17 @@ def: "A rigid covering that envelops an object." [ncithesaurus:Shell, Wikipedia: subset: grouping_class xref: ncithesaurus:Shell xref: Wikipedia:Seashell -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0002416 ! integumental system property_value: editor_note "may be obsoleted after integumental system overhaul" xsd:string property_value: RO:0002161 NCBITaxon:32525 +[Term] +id: UBERON:0006614 +name: aponeurosis +is_a: UBERON:0000158 ! membranous layer +relationship: part_of UBERON:0001630 ! muscle organ + [Term] id: UBERON:0006615 name: venous sinus @@ -277145,6 +389517,22 @@ xref: ZFA:0007072 is_a: UBERON:0003920 ! venous blood vessel property_value: editor_note "check if it is valid to group ZFA class here." xsd:string +[Term] +id: UBERON:0006616 +name: right external ear +is_a: UBERON:0001691 ! external ear +intersection_of: UBERON:0001691 ! external ear +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0006617 +name: left external ear +is_a: UBERON:0001691 ! external ear +intersection_of: UBERON:0001691 ! external ear +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + [Term] id: UBERON:0006618 name: atrium auricular region @@ -277172,6 +389560,22 @@ is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:0002081 ! cardiac atrium +[Term] +id: UBERON:0006632 +name: musculo-phrenic artery +is_a: UBERON:0002057 ! phrenic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0002456 ! internal thoracic artery +intersection_of: supplies UBERON:0001103 ! diaphragm +relationship: branching_part_of UBERON:0002456 ! internal thoracic artery + +[Term] +id: UBERON:0006633 +name: coracoid process of scapula +is_a: UBERON:0005913 ! zone of bone organ +relationship: only_in_taxon NCBITaxon:40674 ! Mammalia +relationship: part_of UBERON:0006849 ! scapula + [Term] id: UBERON:0006635 name: anterior abdominal wall @@ -277187,6 +389591,30 @@ xref: Wikipedia:Abdominal_wall is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0003697 ! abdominal wall +[Term] +id: UBERON:0006642 +name: muscle layer of oviduct +namespace: uberon +def: "A muscle layer that is part of a fallopian tube." [OBOL:automatic] +synonym: "muscle layer of fallopian tube" EXACT [FMA:18318] +synonym: "muscle layer of oviduct" EXACT [FMA:18318] +synonym: "muscle layer of uterine tube" EXACT [FMA:18318] +synonym: "muscular coat of uterine tube" EXACT [FMA:18318] +synonym: "muscular layer of uterine tube" EXACT [FMA:18318] +synonym: "muscularis of uterine tube" EXACT [FMA:18318] +synonym: "tunica muscularis (Tuba uterina)" EXACT [FMA:18318] +synonym: "tunica muscularis tubae uterinae" EXACT LATIN [FMA:18318, FMA:TA] +synonym: "uterine tubal muscularis" EXACT [FMA:18318] +xref: EMAPA:29046 +xref: FMA:18318 +xref: SCTID:259488000 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 ! fallopian tube + [Term] id: UBERON:0006643 name: tunica albuginea of testis @@ -277214,6 +389642,45 @@ relationship: part_of UBERON:0000473 ! testis property_value: UBPROP:0000001 "The layer of connective tissue covering the testicles. [Wikipedia_(15/09/09)][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000801", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "The tunica albuginea testis is the major component of the capsule of mammalian testes. (...) Our results from studying the mole provide evidence that the spatio-temporal pattern of testis development is not perfectly conserved in mammals, since we found differences with respect to the mouse testis organogenesis. This fact is even more significant when we consider that, apart from the mouse, the mole is probably the one of the best-known mammalian species in terms of the genetic control of testis development, implying that more peculiarities would be found if more species were investigated.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000801", ontology="VHOG", source="DOI:10.1387/ijdb.072470fc The spatio-temporal pattern of testis organogenesis in mammals - insights from the mole. The International Journal of Developmental Biology (2009)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0006645 +name: adventitia of epididymis +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0005742 ! adventitia +intersection_of: UBERON:0005742 ! adventitia +intersection_of: part_of UBERON:0001301 ! epididymis +relationship: part_of UBERON:0001301 ! epididymis + +[Term] +id: UBERON:0006646 +name: muscle layer of epididymis +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0001301 ! epididymis +relationship: part_of UBERON:0001301 ! epididymis + +[Term] +id: UBERON:0006647 +name: adventitia of ductus deferens +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0005742 ! adventitia +intersection_of: UBERON:0005742 ! adventitia +intersection_of: part_of UBERON:0001000 ! vas deferens +relationship: part_of UBERON:0001000 ! vas deferens + +[Term] +id: UBERON:0006648 +name: adventitia of seminal vesicle +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0005742 ! adventitia +intersection_of: UBERON:0005742 ! adventitia +intersection_of: part_of UBERON:0000998 ! seminal vesicle +relationship: part_of UBERON:0000998 ! seminal vesicle + [Term] id: UBERON:0006650 name: tunica vaginalis testis @@ -277239,12 +389706,33 @@ is_a: UBERON:0000158 {source="FMA"} ! membranous layer is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure relationship: develops_from UBERON:0005344 {source="Wikipedia"} ! peritoneal vaginal process +relationship: has_part UBERON:0001136 ! mesothelium relationship: part_of UBERON:0000473 {source="EMAPA"} ! testis property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray1148.png xsd:anyURI property_value: UBPROP:0000001 "The tunica vaginalis is the serous covering of the testis. It is a pouch of serous membrane, derived from the saccus vaginalis of the peritoneum, which in the fetus preceded the descent of the testis from the abdomen into the scrotum. After its descent, that portion of the pouch which extends from the abdominal inguinal ring to near the upper part of the gland becomes obliterated; the lower portion remains as a shut sac, which invests the surface of the testis, and is reflected on to the internal surface of the scrotum; hence it may be described as consisting of a visceral and a parietal lamina." xsd:string {source="Wikipedia:Tunica_vaginalis"} property_value: UBPROP:0000010 "tunica vaginalis testis has two layers: visceral and parietal; the visceral layer lies on the anterolateral surface of the testis and epididymis; the parietal layer lines the inner surface of the scrotal sac" xsd:string property_value: UBPROP:0000012 "we follow FMA is classifying as membranous layer - but this does not account for relationship to mesolthelium (subclass or has part?). The FMA also has 'sac of tunica vaginalis', which is a serous sac.[FMA]" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0006652 +name: muscular layer of vagina +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + +[Term] +id: UBERON:0006653 +name: glans clitoris +is_a: UBERON:0008324 ! erectile tissue +is_a: UBERON:0035651 ! glans +intersection_of: UBERON:0035651 ! glans +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: develops_from UBERON:0013240 ! future glans clitoris +relationship: part_of UBERON:0002411 ! clitoris + [Term] id: UBERON:0006657 name: glenoid fossa @@ -277266,6 +389754,7 @@ xref: SCTID:181914008 xref: UMLS:C1261046 {source="ncithesaurus:Glenoid_Fossa"} xref: Wikipedia:Glenoid_cavity is_a: UBERON:0004704 ! bone fossa +relationship: adjacent_to UBERON:0006849 ! scapula relationship: part_of UBERON:0004753 ! scapulocoracoid property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray328.png xsd:anyURI property_value: UBPROP:0000001 "Cavity for the articulation of the forelimb formed by the scapula, coracoid, and clavicle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000749", ontology="AAO", source="AAO:LAP"} @@ -277287,6 +389776,9 @@ xref: galen:InterphalangealJoint xref: NCIT:C101527 is_a: UBERON:0003841 ! autopod joint is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0003221 {cardinality="2"} ! phalanx +relationship: connects UBERON:0003221 ! phalanx relationship: part_of UBERON:0002544 {source="cjm"} ! digit property_value: UBPROP:0000001 "Hinge joints between the phalanges of the hand or foot[ncithesaurus:Interphalangeal_Joint]." xsd:string {source="ncithesaurus:Interphalangeal_Joint"} @@ -277319,6 +389811,7 @@ xref: UMLS:C0225358 {source="ncithesaurus:Muscle_Layer"} xref: Wikipedia:Muscular_layer is_a: UBERON:0018260 ! layer of muscle tissue relationship: adjacent_to UBERON:0000009 ! submucosa +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: editor_note "currently this class conflates a generic layer of muscle and a specific layer found lining the digestive tract (the muscularis externa), typically composed of circular and longitudinal layers (although this varies)" xsd:string property_value: RO:0002171 UBERON:0000009 property_value: RO:0002171 UBERON:0006676 @@ -277330,6 +389823,7 @@ id: UBERON:0006664 name: greater palatine artery namespace: uberon def: "The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity." [Wikipedia:Greater_palatine_artery] +subset: human_reference_atlas synonym: "arteria palatina major" RELATED LATIN [Wikipedia:Greater_palatine_artery] synonym: "major palatine artery" EXACT [MA:0001993] xref: EMAPA:18754 @@ -277340,6 +389834,7 @@ xref: Wikipedia:Greater_palatine_artery is_a: UBERON:0001637 ! artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest property_value: editor_note "TODO - check for synonymy between greater and major; branching_part_of relation is made in FMA at level of descending GPA" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006668 @@ -277373,6 +389868,7 @@ xref: SCTID:244943002 xref: UMLS:C0230162 {source="ncithesaurus:Central_Tendon_of_the_Diaphragm"} xref: VHOG:0001399 xref: Wikipedia:Central_tendon_of_diaphragm +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000043 ! tendon is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue @@ -277381,6 +389877,15 @@ relationship: immediate_transformation_of UBERON:0006239 {evidence="definitional relationship: part_of UBERON:0001103 {source="VHOG"} ! diaphragm property_value: UBPROP:0000003 "In mammals, the diaphragm muscle divides the thoracoabdominal cavity into thorax and abdomen. In most mammals, the diaphragm is a flat sheet with muscle fibers radiating outward from a central tendon, and the diaphragm's apposition to the cranial surface of the liver gives it a dome-shape. Muscle fiber contraction reduces the curvature of the dome, thereby expanding the thoracic cavity and aspirating air into the lungs.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001399", ontology="VHOG", source="DOI:10.1016/j.resp.2006.06.003", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0006671 +name: orbital fat pad +is_a: UBERON:0003566 ! head connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0004088 ! orbital region +relationship: part_of UBERON:0035639 ! ocular adnexa + [Term] id: UBERON:0006675 name: venous valve @@ -277388,6 +389893,7 @@ namespace: uberon def: "A valve that is part of a vein." [OBOL:automatic] synonym: "valve of vein" EXACT [FMA:68095] xref: FMA:68095 +xref: MESH:D055422 is_a: UBERON:0003978 ! valve is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003978 ! valve @@ -277465,6 +389971,14 @@ is_a: UBERON:0002221 ! fontanelle property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png xsd:anyURI property_value: UBPROP:0000008 "In humans it generally closes in 6-8 weeks from birth. A delay in closure is associated with congential hypothyroidism" xsd:string +[Term] +id: UBERON:0006686 +name: spinal vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001130 ! vertebral column +relationship: part_of UBERON:0001130 ! vertebral column + [Term] id: UBERON:0006689 name: frenulum of tongue @@ -277489,6 +390003,28 @@ is_a: UBERON:0005020 ! mucosa of tongue is_a: UBERON:0036293 ! oral frenulum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/13/Gray1202.png xsd:anyURI +[Term] +id: UBERON:0006692 +name: vertebral canal +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0004111 ! anatomical conduit +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: conduit_for UBERON:0002240 ! spinal cord +intersection_of: lumen_of UBERON:0001130 ! vertebral column +relationship: conduit_for UBERON:0002240 ! spinal cord +relationship: lumen_of UBERON:0001130 ! vertebral column +relationship: part_of UBERON:0001130 ! vertebral column +relationship: surrounds UBERON:0002240 ! spinal cord + +[Term] +id: UBERON:0006694 +name: cerebellum vasculature +is_a: UBERON:0006876 ! vasculature of organ +is_a: UBERON:0036303 ! vasculature of central nervous system +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum + [Term] id: UBERON:0006695 name: mammillary axonal complex @@ -277523,9 +390059,20 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre relationship: immediate_transformation_of UBERON:0001761 ! future foramen cecum relationship: part_of UBERON:0003357 {source="EHDAA2"} ! epithelium of tongue relationship: part_of UBERON:0009471 ! dorsum of tongue -property_value: depicted:by Foramen:caecum.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/a/a3/Foramen_caecum.png xsd:anyURI property_value: editor_note "consider merging with FC of thyroid" xsd:string +[Term] +id: UBERON:0006715 +name: radio-ulna +is_a: UBERON:0003466 ! forelimb zeugopod bone +is_a: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: develops_from UBERON:0010848 ! radius-ulna cartilage element +relationship: RO:0002374 UBERON:0001423 ! derived from ancestral fusion of radius bone +relationship: RO:0002374 UBERON:0001424 ! derived from ancestral fusion of ulna + [Term] id: UBERON:0006716 name: mesopodium region @@ -277536,8 +390083,15 @@ synonym: "mesopod" RELATED [] synonym: "mesopodial limb segment" EXACT [MA:th] synonym: "mesopodial segment" EXACT [] xref: Wikipedia:Carpus_and_tarsus_of_land_vertebrates +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: distally_connected_to UBERON:0009877 ! metapodium region +intersection_of: proximally_connected_to UBERON:0002471 ! zeugopod +relationship: distally_connected_to UBERON:0009877 ! metapodium region +relationship: has_skeleton UBERON:0009878 ! mesopodial skeleton relationship: part_of UBERON:0002470 {source="MA:th"} ! autopod region +relationship: proximally_connected_to UBERON:0002471 ! zeugopod property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group" xsd:string [Term] @@ -277551,10 +390105,15 @@ synonym: "autopodium" RELATED [VSAO:0005019, VSAO:NI] synonym: "skeletal parts of autopod" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of autopod" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0005019 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002470 ! autopod region relationship: part_of UBERON:0002470 ! autopod region relationship: part_of UBERON:0004381 ! skeleton of limb +relationship: proximally_connected_to UBERON:0011584 ! zeugopodial skeleton +relationship: skeleton_of UBERON:0002470 ! autopod region property_value: UBPROP:0000001 "Distal section of the limb skeleton, consisting of the anterior autopodium or posterior autopodium.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005019", ontology="VSAO", source="VSAO:NI"} property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group" xsd:string @@ -277714,6 +390273,7 @@ xref: Wikipedia:Modiolus_(cochlea) is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0001844 ! cochlea relationship: part_of UBERON:0007223 {source="MA"} ! osseus cochlea property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png xsd:anyURI @@ -277747,6 +390307,7 @@ id: UBERON:0006729 name: liver perisinusoidal space namespace: uberon def: "The extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma." [ISBN:0-683-40008-8, MP:0008988] +subset: human_reference_atlas subset: pheno_slim synonym: "Disse's space" EXACT [FMA:63162] synonym: "hepatic perisinusoidal space" EXACT [FMA:63162] @@ -277763,6 +390324,7 @@ xref: Wikipedia:Space_of_Disse is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space relationship: part_of UBERON:0004647 ! liver lobule +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006756 @@ -277825,8 +390387,8 @@ synonym: "corneal limbus" EXACT [FMA:58342] synonym: "corneal-scleral limbus" EXACT [PMID:17051547] synonym: "corneal-scleral limbus" EXACT [http://www.ncbi.nlm.nih.gov/pubmed/17051547] synonym: "corneoscleral junction" EXACT [GAID:896] -synonym: "limbus corneae" EXACT LATIN [http://en.wikipedia.org/wiki/Corneal_limbus] synonym: "limbus corneae" EXACT LATIN [Wikipedia:Corneal_limbus] +synonym: "limbus corneae" EXACT LATIN [http://en.wikipedia.org/wiki/Corneal_limbus] synonym: "limbus corneae" RELATED LATIN [http://en.wikipedia.org/wiki/Corneal_limbus] synonym: "limbus corneae" RELATED LATIN [Wikipedia:Corneal_limbus] synonym: "sclerocorneal junction" EXACT [FMA:58342] @@ -277867,6 +390429,8 @@ xref: NCIT:C32365 xref: UMLS:C1179037 {source="ncithesaurus:Conjunctival_Epithelium"} is_a: UBERON:0010304 {source="FMA"} ! non-keratinized stratified squamous epithelium is_a: UBERON:0015808 ! eye epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 {source="BTO"} ! conjunctiva [Term] @@ -277887,7 +390451,7 @@ xref: EMAPA:37541 {source="MA:th"} xref: FMA:32851 xref: galen:FemoralHead xref: MA:0003050 -xref: MESH:A02.835.232.500.247.343 +xref: MESH:D005270 xref: NCIT:C32718 xref: SCTID:361791000 xref: UMLS:C0015813 {source="ncithesaurus:Head_of_the_Femur"} @@ -277943,7 +390507,7 @@ comment: The term "tectal plate" (or "quadrigeminal plate") is used to describe synonym: "lamina quadrigemina" EXACT LATIN [FMA:77488, FMA:TA] synonym: "quadrigeminal plate" EXACT [FMA:77488] xref: FMA:77488 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1374 +xref: neuronames:1374 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure relationship: part_of UBERON:0009616 ! presumptive midbrain @@ -278067,12 +390631,16 @@ synonym: "skeleton of nose" EXACT [FMA:60116] xref: AAO:0000320 xref: FMA:60116 xref: SCTID:281486007 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0000004 ! nose relationship: part_of UBERON:0000004 {source="FMA"} ! nose relationship: part_of UBERON:0003113 {notes="facial series", source="Kardong-abduced"} ! dermatocranium relationship: part_of UBERON:0011156 ! facial skeleton +relationship: skeleton_of UBERON:0000004 ! nose [Term] id: UBERON:0006815 @@ -278112,6 +390680,25 @@ xref: SCTID:304590006 xref: Wikipedia:Head_of_ulna is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004386 ! epiphysis of ulna +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001424 ! ulna + +[Term] +id: UBERON:0006833 +name: lumen of trachea +namespace: uberon +def: "An anatomical space that surrounded_by a trachea." [OBOL:automatic] +synonym: "lumen of cartilaginous trachea" EXACT [OBOL:automatic] +synonym: "tracheal lumen" EXACT [FMA:7469] +xref: FMA:7469 +xref: SCTID:197486000 +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0003126 ! trachea +relationship: luminal_space_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0003126 ! trachea [Term] id: UBERON:0006834 @@ -278131,6 +390718,28 @@ relationship: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: part_of UBERON:0000474 ! female reproductive system relationship: site_of GO:0009790 ! embryo development +[Term] +id: UBERON:0006841 +name: central vein of liver +namespace: uberon +def: "Vein that is central to a lobule in the liver." [ZFA:0005168] +subset: human_reference_atlas +subset: vertebrate_core +synonym: "central vein" BROAD [ZFA:0005168] +synonym: "terminal branch of hepatic vein" EXACT [FMA:17544] +synonym: "terminal hepatic venule" EXACT [FMA:17544] +synonym: "vena centralis (hepar)" EXACT [FMA:17544] +xref: FMA:17544 +xref: NCIT:C32281 +xref: SCTID:272023004 +xref: TAO:0005168 +xref: Wikipedia:Central_veins_of_liver +xref: ZFA:0005168 +is_a: UBERON:0013126 ! vein of abdomen +is_a: UBERON:0015796 ! liver blood vessel +relationship: part_of UBERON:0004647 ! liver lobule +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0006846 name: surface groove @@ -278181,9 +390790,15 @@ xref: ZFA:0000583 is_a: UBERON:0002513 ! endochondral bone is_a: UBERON:0007829 ! pectoral girdle bone is_a: UBERON:0015057 ! scapula endochondral element +intersection_of: UBERON:0015057 ! scapula endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0004753 {source="ZFA"} ! scapulocoracoid relationship: develops_from UBERON:0006290 {evidence="definitional"} ! scapula cartilage element -property_value: depicted:by Pectoral:girdles-en.svg xsd:anyURI +relationship: distally_connected_to UBERON:0000976 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! humerus +relationship: distally_connected_to UBERON:0007272 ! pectoral appendage skeleton +relationship: overlaps UBERON:0001470 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! glenohumeral joint +relationship: overlaps UBERON:0003692 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! acromioclavicular joint +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg xsd:anyURI property_value: UBPROP:0000001 "Endochondral bone that is located medial to the cleithrum, and articulates ventrally with the coracoid, medially with the mesocoracoid when the later is present and posteriorly with the upper one to three proximal radials. The scapula develops from the scapulocoracoid cartilage and belongs to the primary pectoral girdle. It may be perforated by the scapular foramen or it may be notched ventr and forms together with a similar notch of the coracoid the scapulocoracoid foramen[TAO:0000583]." xsd:string {source="TAO:0000583"} property_value: UBPROP:0000001 "Paired bony elements of endochondral origin. They are situated at the level of the jaw articulation, in a vertical position, with the suprascapular margin being dorsal and the glenoid end being ventral.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000751", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000002 "relationship loss: has pars glenoidalis of scapula (AAO:0000753)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000751", ontology="AAO"} @@ -278202,6 +390817,8 @@ synonym: "kidney cortex tubule" EXACT [MA:0002609] xref: EMAPA:18976 xref: MA:0002609 is_a: UBERON:0007685 ! region of nephron tubule +intersection_of: UBERON:0007685 ! region of nephron tubule +intersection_of: part_of UBERON:0001225 ! cortex of kidney relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney [Term] @@ -278242,6 +390859,8 @@ is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: develops_from UBERON:0003064 ! intermediate mesoderm +relationship: has_part CL:0000166 ! chromaffin cell +relationship: has_part CL:0000457 ! biogenic amine secreting cell relationship: part_of UBERON:0010074 ! chromaffin system property_value: editor_note "keep this grouping class so long as it is required for GO" xsd:string property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001141", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"} @@ -278258,6 +390877,7 @@ synonym: "shaft proper of long bone" EXACT [FMA:32688] xref: FMA:32688 xref: MA:0002803 is_a: UBERON:0005055 ! zone of long bone +relationship: contributes_to_morphology_of UBERON:0002495 ! long bone relationship: part_of UBERON:0004769 ! diaphysis property_value: RO:0002171 UBERON:0001438 property_value: UBPROP:0000012 "The MA class is associated with EMAPA:35505 but we associate this with the more precise concept of diaphyseal plate" xsd:string {external_ontology="MA"} @@ -278281,6 +390901,8 @@ xref: SCTID:182048009 xref: Wikipedia:Body_of_femur is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0000981 ! femur property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray244.png xsd:anyURI property_value: UBPROP:0000001 "The body of the femur (or shaft), almost cylindrical in form, is a little broader above than in the center, broadest and somewhat flattened from before backward below. It is slightly arched, so as to be convex in front, and concave behind, where it is strengthened by a prominent longitudinal ridge, the linea aspera. It presents for examination three borders, separating three surfaces. Of the borders, one, the linea aspera, is posterior, one is medial, and the other, lateral[Wikipedia:Body_of_femur]." xsd:string {source="Wikipedia:Body_of_femur"} @@ -278294,6 +390916,8 @@ subset: pheno_slim xref: FMA:32878 is_a: UBERON:0004378 ! proximal metaphysis is_a: UBERON:0006865 ! metaphysis of femur +intersection_of: UBERON:0004378 ! proximal metaphysis +intersection_of: part_of UBERON:0000981 ! femur [Term] id: UBERON:0006864 @@ -278304,6 +390928,8 @@ subset: pheno_slim xref: FMA:32881 is_a: UBERON:0004377 ! distal metaphysis is_a: UBERON:0006865 ! metaphysis of femur +intersection_of: UBERON:0004377 ! distal metaphysis +intersection_of: part_of UBERON:0000981 ! femur [Term] id: UBERON:0006865 @@ -278317,6 +390943,8 @@ xref: FMA:32875 xref: MA:0003052 is_a: UBERON:0001438 ! metaphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0006862 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! diaphysis of femur [Term] @@ -278359,7 +390987,10 @@ subset: organ_slim xref: FBbt:00004958 xref: WBbt:0006870 is_a: UBERON:0005399 ! male reproductive gland +intersection_of: UBERON:0002530 ! gland +intersection_of: produces UBERON:0006530 ! seminal fluid relationship: part_of UBERON:0006947 ! male genital duct +relationship: produces UBERON:0006530 ! seminal fluid [Term] id: UBERON:0006871 @@ -278379,9 +391010,20 @@ xref: FMA:296800 xref: NCIT:C34177 xref: UMLS:C1517291 {source="ncithesaurus:Foot_Plate"} is_a: UBERON:0010130 ! embryonic autopod plate +intersection_of: UBERON:0010130 ! embryonic autopod plate +intersection_of: has_potential_to_develop_into UBERON:0002387 ! pes relationship: develops_from UBERON:0005418 ! hindlimb bud +relationship: has_potential_to_develop_into UBERON:0002387 ! pes property_value: UBPROP:0000012 "EHDAA2 does not have a single class for footplate, but includes epithelium, mesenchyme and AER" xsd:string {external_ontology="EHDAA2"} +[Term] +id: UBERON:0006872 +name: handplate apical ectodermal ridge +is_a: UBERON:0004356 ! apical ectodermal ridge +intersection_of: UBERON:0004356 ! apical ectodermal ridge +intersection_of: part_of UBERON:0006875 ! embryonic handplate +relationship: part_of UBERON:0006875 ! embryonic handplate + [Term] id: UBERON:0006875 name: embryonic handplate @@ -278397,7 +391039,10 @@ xref: FMA:296794 xref: NCIT:C34185 xref: UMLS:C1512334 {source="ncithesaurus:Hand_Plate"} is_a: UBERON:0010130 ! embryonic autopod plate +intersection_of: UBERON:0010130 ! embryonic autopod plate +intersection_of: has_potential_to_develop_into UBERON:0002398 ! manus relationship: develops_from UBERON:0005417 ! forelimb bud +relationship: has_potential_to_develop_into UBERON:0002398 ! manus [Term] id: UBERON:0006876 @@ -278429,6 +391074,8 @@ xref: FMA:73748 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver property_value: UBPROP:0000012 "the EHDAA2 term and the FMA term may not be exact equivalents - check" xsd:string {external_ontology="EHDAA2"} @@ -278577,6 +391224,14 @@ is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000486 ! multilaminar epithelium intersection_of: has_part CL:0000076 ! squamous epithelial cell +[Term] +id: UBERON:0006916 +name: non-keratinized epithelium of tongue +is_a: UBERON:0006919 ! tongue squamous epithelium +is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium +intersection_of: UBERON:0010304 ! non-keratinized stratified squamous epithelium +intersection_of: part_of UBERON:0001723 ! tongue + [Term] id: UBERON:0006919 name: tongue squamous epithelium @@ -278632,6 +391287,7 @@ id: UBERON:0006922 name: cervix squamous epithelium namespace: uberon def: "The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane." [http://www.asccp.org/practicemanagement/cervix/histologyofthenormalcervix/tabid/5842/default.aspx] +subset: human_reference_atlas subset: pheno_slim synonym: "cervical squamous epithelium" EXACT [] xref: MA:0001725 @@ -278639,6 +391295,17 @@ xref: NCIT:C49219 xref: UMLS:C1707351 {source="ncithesaurus:Cervix_Squamous_Epithelium"} is_a: UBERON:0004801 ! cervix epithelium is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium +intersection_of: UBERON:0006914 ! squamous epithelium +intersection_of: part_of UBERON:0000002 ! uterine cervix +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0006923 +name: vagina squamous epithelium +is_a: UBERON:0001344 ! epithelium of vagina +is_a: UBERON:0006915 ! stratified squamous epithelium +intersection_of: UBERON:0006914 ! squamous epithelium +intersection_of: part_of UBERON:0000996 ! vagina [Term] id: UBERON:0006924 @@ -278726,6 +391393,8 @@ xref: MA:0002892 xref: RETIRED_EHDAA2:0000834 is_a: UBERON:0006934 ! sensory epithelium is_a: UBERON:0006937 ! inner ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001862 ! vestibular labyrinth relationship: part_of UBERON:0001862 ! vestibular labyrinth [Term] @@ -278763,11 +391432,16 @@ id: UBERON:0006936 name: thymus subcapsular epithelium namespace: uberon def: "The epithelial cells lining the capsule and trabeculae of the thymus." [ISBN:0-8153-1691-7, MGI:cwg, MP:0002369] +subset: human_reference_atlas subset: pheno_slim xref: MA:0000769 is_a: UBERON:0003846 ! thymus epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002122 ! capsule of thymus +relationship: has_part CL:0002294 ! type-1 epithelial cell of thymus relationship: part_of UBERON:0002122 ! capsule of thymus property_value: editor_note "TODO - check whether this is part of the thymus or borders it" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006937 @@ -278780,8 +391454,19 @@ xref: MA:0001189 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0015807 ! ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001846 ! internal ear +[Term] +id: UBERON:0006938 +name: pinna surface epithelium +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0015814 ! outer ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001757 ! pinna +relationship: part_of UBERON:0001757 ! pinna + [Term] id: UBERON:0006946 name: efferent duct @@ -278803,6 +391488,10 @@ xref: UMLS:C0228013 {source="ncithesaurus:Efferent_Ductule"} xref: Wikipedia:Efferent_ducts is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system +relationship: channel_for CL:0000019 ! sperm +relationship: channels_from UBERON:0003959 ! rete testis +relationship: channels_into UBERON:0001301 ! epididymis +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0006947 {source="FMA"} ! male genital duct property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg xsd:anyURI property_value: UBPROP:0000001 "Any of a group ranging from one to twelve (varies in species) small seminal ducts per testis which transport sperm from the testes to the kidney.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010532", ontology="AAO", source="AAO:BJB"} @@ -278824,10 +391513,31 @@ xref: ZFA:0001268 is_a: UBERON:0000025 ! tube is_a: UBERON:0005904 ! duct of male reproductive system is_a: UBERON:0015212 ! lateral structure +relationship: channel_for UBERON:0001968 ! semen +relationship: channels_from UBERON:0000473 ! testis +relationship: in_lateral_side_of UBERON:0004054 ! internal male genitalia relationship: part_of UBERON:0004054 ! internal male genitalia property_value: UBPROP:0000008 "we use this as a generic grouping class for a number of taxa" xsd:string property_value: UBPROP:0000012 "in FMA includes as parts: seminal vesicle, efferent ductule (vas efferentia), epididymis, deferent duct (vas deferens), ejaculatory duct" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0006948 +name: efferent duct epithelium +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0006946 ! efferent duct +relationship: part_of UBERON:0006946 ! efferent duct + +[Term] +id: UBERON:0006953 +name: ejaculatory duct epithelium +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000999 ! ejaculatory duct +relationship: part_of UBERON:0000999 ! ejaculatory duct + [Term] id: UBERON:0006954 name: mammary gland myoepithelium @@ -278852,8 +391562,19 @@ def: "An epithelium that is part of a uterus." [OBOL:automatic] synonym: "uterus epithelium" RELATED [BTO:0003082] xref: BTO:0003082 is_a: UBERON:0004804 ! oviduct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus +[Term] +id: UBERON:0006957 +name: submandibular gland primordium epithelium +is_a: UBERON:0003236 ! epithelium of lower jaw +is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0006298 ! submandibular gland primordium +relationship: part_of UBERON:0006298 ! submandibular gland primordium + [Term] id: UBERON:0006959 name: mandible angular process @@ -278876,6 +391597,7 @@ id: UBERON:0006960 name: ovary stroma namespace: uberon def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." [Wikipedia:Stroma_of_ovary] +subset: human_reference_atlas synonym: "interstitial tissue of ovary" EXACT [FMA:18626] synonym: "ovarian stroma" EXACT [FMA:18626] synonym: "ovary stroma" EXACT [MA:0002991] @@ -278897,6 +391619,13 @@ intersection_of: UBERON:0003891 ! stroma intersection_of: part_of UBERON:0000992 ! ovary relationship: has_part CL:0002095 {source="FMA"} ! hilus cell of ovary relationship: part_of UBERON:0000992 ! ovary +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0006964 +name: pars distalis of adenohypophysis +is_a: UBERON:0010371 ! ecto-epithelium +relationship: part_of UBERON:0002196 ! adenohypophysis [Term] id: UBERON:0006965 @@ -279002,6 +391731,7 @@ xref: http://www.snomedbrowser.com/Codes/Details/360387000 xref: SCTID:360387000 xref: VHOG:0001641 xref: XAO:0000235 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: developmentally_induced_by UBERON:0009881 ! anterior lateral plate mesoderm @@ -279024,6 +391754,26 @@ intersection_of: existence_starts_with UBERON:0000107 ! cleavage stage relationship: existence_ends_with UBERON:0000107 ! cleavage stage relationship: existence_starts_with UBERON:0000107 ! cleavage stage +[Term] +id: UBERON:0007021 +name: sexually immature organism +namespace: uberon +def: "A multicellular organism that is at the juvenile stage." [OBOL:automatic] +synonym: "juvenile" BROAD [] +synonym: "juvenile organism" EXACT [BILA:0000076] +synonym: "juveniles" EXACT PLURAL [TAO:0002047] +xref: BILA:0000076 +xref: http://neurolex.org/wiki/Category\:Juvenile_organism +xref: TAO:0002047 +is_a: UBERON:0000468 ! multicellular organism +intersection_of: UBERON:0000468 ! multicellular organism +intersection_of: existence_ends_with UBERON:0000112 ! sexually immature stage +intersection_of: existence_starts_with UBERON:0000112 ! sexually immature stage +relationship: existence_ends_with UBERON:0000112 ! sexually immature stage +relationship: existence_starts_with UBERON:0000112 ! sexually immature stage +relationship: has_quality PATO:0001190 ! juvenile +property_value: UBPROP:0000001 "Whole organism that is not fully grown or sexually mature.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002047", ontology="TAO", source="TAO:wd"} + [Term] id: UBERON:0007023 name: adult organism @@ -279040,6 +391790,12 @@ xref: NCIT:C17600 xref: TAO:0002046 xref: UMLS:C0001675 {source="ncithesaurus:Adult"} is_a: UBERON:0000468 ! multicellular organism +intersection_of: UBERON:0000468 ! multicellular organism +intersection_of: existence_ends_with UBERON:0000113 ! post-juvenile adult stage +intersection_of: existence_starts_with UBERON:0000113 ! post-juvenile adult stage +relationship: existence_ends_with UBERON:0000113 ! post-juvenile adult stage +relationship: existence_starts_with UBERON:0000113 ! post-juvenile adult stage +property_value: IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl property_value: UBPROP:0000001 "Whole organism that is fully grown or sexually mature.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002046", ontology="TAO", source="TAO:wd"} [Term] @@ -279123,6 +391879,40 @@ relationship: capable_of GO:0008015 {notes="GO uses blood circulation genericall relationship: has_part CL:0002494 ! cardiocyte property_value: UBPROP:0000008 "note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis" xsd:string +[Term] +id: UBERON:0007106 +name: chorionic villus +namespace: uberon +def: "One of the minute vascular projections of the fetal chorion that combines with maternal uterine tissue to form the placenta." [BTO:0001161, Wikipedia:Chorionic_villi] +subset: human_reference_atlas +synonym: "chorionic villi" RELATED PLURAL [MESH:A16.254.403.473.200] +synonym: "chorionic villous" RELATED [Wikipedia:Chorionic_villi] +synonym: "chorionic villus" RELATED [GAID:1300] +synonym: "embryonic part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] +synonym: "embryonic placenta" RELATED [http://orcid.org/0000-0002-6601-2165] +synonym: "fetal part of placenta" RELATED [http://orcid.org/0000-0002-6601-2165] +synonym: "fetal placenta" RELATED [http://orcid.org/0000-0002-6601-2165] +synonym: "placental villi" RELATED PLURAL [GAID:1300] +synonym: "placental villous" RELATED [] +synonym: "placental villus" RELATED [GAID:1300] +synonym: "villous chorion" RELATED [] +synonym: "villous of placenta" RELATED [] +xref: BTO:0001161 +xref: EHDAA2:0004717 +xref: MESH:D002824 +xref: NCIT:C34125 +xref: SCTID:360403003 +xref: UMLS:C0008508 {source="ncithesaurus:Chorionic_Villus"} +xref: Wikipedia:Chorionic_villi +is_a: UBERON:0000478 ! extraembryonic structure +is_a: UBERON:0002050 ! embryonic structure +relationship: develops_from UBERON:0004027 {source="MP-def"} ! chorionic plate +relationship: part_of UBERON:0003124 {source="BTO"} ! chorion membrane +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray29.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000008 "The mouse and human placentas have labyrinthine and villous types of interdigitation between maternal and fetal tissues, respectively" xsd:string +property_value: UBPROP:0000010 "The bulk of the villi consist of connective tissues in which blood vessels are found. Most of the cells in the connective tissue core of the villi are fibroblasts. Macrophages known as Hofbauer cells are also present." xsd:string + [Term] id: UBERON:0007115 name: deciduous tooth @@ -279135,7 +391925,7 @@ synonym: "primary tooth" EXACT [FMA:55655] synonym: "temporary tooth" EXACT [FMA:55655] xref: FMA:55655 xref: GAID:1266 -xref: MESH:A14.254.860.700 +xref: MESH:D014094 xref: NCIT:C33745 xref: SCTID:245612004 xref: UMLS:C0040455 {source="ncithesaurus:Temporary_Tooth"} @@ -279162,7 +391952,7 @@ synonym: "set of primary teeth" EXACT [FMA:75151] synonym: "tooth of primary dentition" EXACT [] xref: FMA:75151 xref: GAID:1252 -xref: MESH:A14.254.245 +xref: MESH:D014094 is_a: UBERON:0003672 ! dentition [Term] @@ -279177,12 +391967,14 @@ synonym: "umbilical region" EXACT [FMA:61584] xref: FMA:61584 xref: GAID:29 xref: galen:Umbilicus -xref: MESH:A01.047.849 +xref: MESH:D014472 xref: NCIT:C77533 xref: SCTID:243961003 xref: UMLS:C0041638 {source="ncithesaurus:Umbilicus"} xref: Wikipedia:Navel +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000479 ! tissue +relationship: has_developmental_contribution_from UBERON:0002331 ! umbilical cord relationship: part_of UBERON:0000916 ! abdomen property_value: UBPROP:0000007 "omphalo" xsd:string property_value: UBPROP:0000007 "umbilical" xsd:string @@ -279200,7 +391992,7 @@ synonym: "neck of the femur" RELATED [Wikipedia:Femur_neck] xref: FMA:42385 xref: GAID:201 xref: galen:NeckOfFemur -xref: MESH:A02.835.232.500.247.510 +xref: MESH:D005272 xref: NCIT:C61563 xref: SCTID:361792007 xref: UMLS:C0015815 {source="ncithesaurus:Femoral_Neck"} @@ -279208,6 +392000,8 @@ xref: Wikipedia:Femur_neck is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005055 ! zone of long bone is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0000981 ! femur relationship: part_of UBERON:0006863 ! proximal metaphysis of femur property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png xsd:anyURI @@ -279238,7 +392032,7 @@ synonym: "præmolares" RELATED [Wikipedia:Premolar] synonym: "secondary premolar tooth" NARROW [FMA:55637] xref: FMA:55637 xref: GAID:1261 -xref: MESH:A14.254.860.150 +xref: MESH:D001641 xref: NCIT:C32201 xref: SCTID:304572005 xref: UMLS:C1704302 {source="ncithesaurus:Bicuspid_Tooth"} @@ -279419,11 +392213,23 @@ xref: Wikipedia:Pharyngeal_pouch_(embryology)#Fourth_pouch xref: XAO:0000254 xref: ZFA:0001134 is_a: UBERON:0004117 ! pharyngeal pouch +intersection_of: UBERON:0004117 ! pharyngeal pouch +intersection_of: overlaps UBERON:0003115 ! pharyngeal arch 4 +intersection_of: overlaps UBERON:0003116 ! pharyngeal arch 5 +relationship: overlaps UBERON:0003115 ! pharyngeal arch 4 +relationship: overlaps UBERON:0003116 ! pharyngeal arch 5 property_value: UBPROP:0000001 "A pouch that is situated between the 4th and 5th pharyngeal arch. [ISBN:0124020607][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000971", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000001 "Fourth of the pharyngeal (endodermal) evaginations between the visceral arches from which the Eustachian tube is derived; pouches 2-4 open as gill slits.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011117", ontology="AAO", source="ISBN:0-226-55763-4"} property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000971", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000011 "Derivatives include: superior parathyroid glands and ultimobranchial body which forms the parafollicular C-Cells of the thyroid gland. Musculature and cartilage of larynx (along with the sixth pharyngeal pouch)[WP] in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland (the parathyroid glands derived from the third pouches descend with the thymus and are carried to a more inferior position than the parathyroid glands that are derived from the fourth pouches); the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland. In the mouse, but also in the rat and hamster, the dorsal fourth pouch does not generate a parathyroid. Thus, rodents develop only one pair of parathyroid glands." xsd:string {source="MP"} +[Term] +id: UBERON:0007128 +name: glomeral mesenchyme +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002050 ! embryonic structure +relationship: develops_from UBERON:0003064 ! intermediate mesoderm + [Term] id: UBERON:0007134 name: trunk ganglion @@ -279547,7 +392353,12 @@ xref: EMAPA:18628 xref: FMA:7241 xref: SCTID:244353007 xref: VHOG:0000822 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0011741 ! cardiac valve leaflet +intersection_of: UBERON:0011741 ! cardiac valve leaflet +intersection_of: part_of UBERON:0002135 ! mitral valve +relationship: attaches_to UBERON:0005995 ! mitral valve anulus +relationship: attaches_to UBERON:0014851 ! chorda tendinea of left ventricle relationship: part_of UBERON:0002135 ! mitral valve property_value: UBPROP:0000001 "Leaf of cardiac valve which has as its parts the anterior, and posterior leaflets that is attached to the chorda tendinea of left ventricle and to the frbrous ring of mitral valve." xsd:string {source="FMA:7241"} property_value: UBPROP:0000003 "The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000822", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} @@ -279557,6 +392368,7 @@ id: UBERON:0007156 name: inferior thyroid vein namespace: uberon def: "The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins." [Wikipedia:Inferior_thyroid_veins] +subset: human_reference_atlas synonym: "inferior thyroid venous tree" EXACT [FMA:4728] synonym: "vena thyroidea inferioris" EXACT [FMA:4728] xref: EMAPA:18763 @@ -279564,6 +392376,7 @@ xref: FMA:4728 xref: SCTID:303423007 xref: Wikipedia:Inferior_thyroid_veins is_a: UBERON:0018246 ! thyroid vein +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007158 @@ -279591,6 +392404,7 @@ synonym: "colonic lumen" RELATED [FMA:18374] xref: EMAPA:18945 xref: FMA:18374 xref: http://www.snomedbrowser.com/Codes/Details/362156004 +xref: SCTID:362156004 is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space @@ -279599,11 +392413,48 @@ intersection_of: luminal_space_of UBERON:0001155 ! colon relationship: luminal_space_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +[Term] +id: UBERON:0007160 +name: inferior petrosal sinus +is_a: UBERON:0017635 ! paired venous dural sinus + +[Term] +id: UBERON:0007171 +name: border of scapula +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0036304 ! anatomical border +intersection_of: UBERON:0036304 ! anatomical border +intersection_of: part_of UBERON:0006849 ! scapula +relationship: part_of UBERON:0006849 ! scapula + +[Term] +id: UBERON:0007172 +name: angle of scapula +is_a: UBERON:0005913 ! zone of bone organ +relationship: part_of UBERON:0006849 ! scapula + +[Term] +id: UBERON:0007173 +name: lateral border of scapula +is_a: UBERON:0007171 ! border of scapula + +[Term] +id: UBERON:0007174 +name: medial border of scapula +is_a: UBERON:0007171 ! border of scapula +relationship: has_developmental_contribution_from UBERON:0002329 ! somite + +[Term] +id: UBERON:0007175 +name: inferior angle of scapula +is_a: UBERON:0007172 ! angle of scapula + [Term] id: UBERON:0007177 name: lamina propria of mucosa of colon namespace: uberon def: "A lamina propria that is part of a colonic mucosa." [OBOL:automatic] +subset: human_reference_atlas synonym: "colonic lamina propria" EXACT [FMA:15657] synonym: "lamina propria mucosae of colon" EXACT [FMA:15657] synonym: "lamina propria of colonic mucosa" EXACT [FMA:15657] @@ -279612,10 +392463,46 @@ xref: EMAPA:27395 xref: FMA:15657 xref: http://www.snomedbrowser.com/Codes/Details/113284008 xref: MA:0003196 +xref: SCTID:113284008 is_a: UBERON:0011189 ! lamina propria of large intestine intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000317 ! colonic mucosa relationship: part_of UBERON:0000317 ! colonic mucosa +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0007181 +name: serosa of infundibulum of uterine tube +namespace: uberon +def: "A serous membrane that is part of a uterine tube infundibulum." [OBOL:automatic] +synonym: "serosa of infundibulum of fallopian tube" EXACT [FMA:18324] +synonym: "serosa of infundibulum of oviduct" EXACT [FMA:18324] +xref: EMAPA:29903 +xref: FMA:18324 +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0003984 ! uterine tube infundibulum +relationship: part_of UBERON:0003983 ! conus arteriosus +relationship: part_of UBERON:0003984 ! uterine tube infundibulum + +[Term] +id: UBERON:0007182 +name: muscle layer of infundibulum of uterine tube +namespace: uberon +def: "A muscle layer that is part of a uterine tube infundibulum." [OBOL:automatic] +synonym: "muscle layer of infundibulum of fallopian tube" EXACT [FMA:18336] +synonym: "muscle layer of infundibulum of oviduct" EXACT [FMA:18336] +synonym: "muscularis of infundibulum of uterine tube" EXACT [FMA:18336] +xref: EMAPA:31264 +xref: FMA:18336 +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0005983 ! heart layer +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0003984 ! uterine tube infundibulum +relationship: part_of UBERON:0003983 ! conus arteriosus +relationship: part_of UBERON:0003984 ! uterine tube infundibulum [Term] id: UBERON:0007188 @@ -279640,6 +392527,7 @@ id: UBERON:0007195 name: stroma of bone marrow namespace: uberon def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." [Wikipedia:Bone_marrow#Stroma] +subset: human_reference_atlas synonym: "bone marrow stroma" EXACT [FMA:21426] xref: CALOHA:TS-0085 xref: FMA:21426 @@ -279652,6 +392540,7 @@ relationship: has_part CL:0002240 ! marrow fibroblast relationship: has_part UBERON:0000332 ! yellow bone marrow relationship: has_part UBERON:0003909 ! sinusoid relationship: part_of UBERON:0002371 ! bone marrow +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007196 @@ -279659,6 +392548,7 @@ name: tracheobronchial tree namespace: uberon alt_id: UBERON:0004102 def: "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." [Wikipedia:Tracheobronchial_tree] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "arbor tracheobronchialis" EXACT LATIN [FMA:7393, FMA:TA] @@ -279669,7 +392559,24 @@ xref: SCTID:361384001 xref: Wikipedia:Tracheobronchial_tree is_a: UBERON:0000062 ! organ is_a: UBERON:0004119 ! endoderm-derived structure +relationship: has_part UBERON:0002185 ! bronchus +relationship: has_part UBERON:0003126 ! trachea +relationship: has_part UBERON:0007592 {source="Wikipedia"} ! ciliated columnar epithelium relationship: part_of UBERON:0001558 ! lower respiratory tract +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0007197 +name: hermaphroditic organism +is_a: UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0007198 +name: hermaphrodite anatomical structure +is_a: UBERON:0014402 ! sex-specific anatomical structure +intersection_of: UBERON:0014402 ! sex-specific anatomical structure +intersection_of: part_of UBERON:0007197 ! hermaphroditic organism +relationship: part_of UBERON:0007197 ! hermaphroditic organism [Term] id: UBERON:0007204 @@ -279719,6 +392626,15 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: develops_from UBERON:0003083 ! trunk neural crest relationship: develops_from UBERON:0003083 ! trunk neural crest +[Term] +id: UBERON:0007220 +name: late embryonic stage +is_a: BFO:0000003 ! occurrent +is_a: UBERON:0000105 ! life cycle stage +relationship: part_of UBERON:0000068 ! embryo stage +relationship: preceded_by UBERON:0000111 ! organogenesis stage +relationship: preceded_by UBERON:0004707 ! pharyngula stage + [Term] id: UBERON:0007223 name: osseus cochlea @@ -279732,6 +392648,15 @@ is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0001844 ! cochlea property_value: editor_note "TODO - check this. in MA, cochlea is not part of the bony labyrinth" xsd:string +[Term] +id: UBERON:0007228 +name: vestibular nucleus +is_a: UBERON:0007635 ! nucleus of medulla oblongata +intersection_of: UBERON:0000125 ! neural nucleus +intersection_of: part_of UBERON:0002673 ! vestibular nuclear complex +relationship: extends_fibers_into UBERON:0003723 ! vestibular nerve +relationship: part_of UBERON:0002673 ! vestibular nuclear complex + [Term] id: UBERON:0007237 name: 1st arch mandibular component @@ -279903,7 +392828,7 @@ xref: Wikipedia:Lingual_tonsils is_a: UBERON:0002372 ! tonsil is_a: UBERON:0015212 ! lateral structure relationship: part_of UBERON:0001723 ! tongue -property_value: depicted:by Illu04:tongue.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg xsd:anyURI [Term] id: UBERON:0007251 @@ -279916,6 +392841,28 @@ is_a: UBERON:0006569 ! diencephalic nucleus relationship: part_of UBERON:0001928 ! preoptic area property_value: RO:0002175 NCBITaxon:117569 {source="Hardisty, p. 320-1"} +[Term] +id: UBERON:0007252 +name: intervertebral disk of cervical vertebra +is_a: UBERON:0001066 ! intervertebral disk +is_a: UBERON:0003601 ! neck cartilage +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0001066 ! intervertebral disk +intersection_of: part_of UBERON:0006072 ! cervical region of vertebral column +relationship: part_of UBERON:0006072 ! cervical region of vertebral column + +[Term] +id: UBERON:0007254 +name: intervertebral disk of thoracic vertebra +is_a: UBERON:0001066 ! intervertebral disk +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0001066 ! intervertebral disk +intersection_of: part_of UBERON:0006073 ! thoracic region of vertebral column +relationship: part_of UBERON:0006073 ! thoracic region of vertebral column + [Term] id: UBERON:0007255 name: intervertebral disk of lumbar vertebra @@ -279928,8 +392875,21 @@ is_a: UBERON:0001066 ! intervertebral disk is_a: UBERON:0005173 ! abdominal segment element is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0001066 ! intervertebral disk +intersection_of: part_of UBERON:0006074 ! lumbar region of vertebral column relationship: part_of UBERON:0006074 ! lumbar region of vertebral column +[Term] +id: UBERON:0007257 +name: intervertebral disk of sacral vertebra +is_a: UBERON:0001066 ! intervertebral disk +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0005179 ! pelvic region element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0001066 ! intervertebral disk +intersection_of: part_of UBERON:0006075 ! sacral region of vertebral column +relationship: part_of UBERON:0006075 ! sacral region of vertebral column + [Term] id: UBERON:0007267 name: trachea pre-cartilage rings @@ -279939,6 +392899,8 @@ xref: EHDAA2:0002070 xref: EHDAA:7082 is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0009505 ! mesenchyme of trachea +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0009505 {source="EHDAA2"} ! mesenchyme of trachea [Term] @@ -279999,6 +392961,7 @@ xref: VSAO:0005000 is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0004710 ! pectoral appendage +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0004710 {source="VSAO"} ! pectoral appendage relationship: skeleton_of UBERON:0004710 ! pectoral appendage property_value: RO:0002475 UBERON:0007273 @@ -280011,6 +392974,7 @@ def: "The collection of all skeletal elements in a pelvic appendage region." [ht is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0004709 ! pelvic appendage +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0004709 {source="VSAO"} ! pelvic appendage relationship: skeleton_of UBERON:0004709 ! pelvic appendage @@ -280207,6 +393171,9 @@ def: "A presumptive structure that has the potential to develop into a rhombomer xref: TAO:0001207 xref: ZFA:0001207 is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0006598 ! presumptive structure +intersection_of: has_potential_to_develop_into UBERON:0005499 ! rhombomere 1 +relationship: has_potential_to_develop_into UBERON:0005499 ! rhombomere 1 [Term] id: UBERON:0007290 @@ -280298,6 +393265,14 @@ intersection_of: UBERON:0006598 ! presumptive structure intersection_of: has_potential_to_develop_into UBERON:0005721 ! pronephric mesoderm relationship: has_potential_to_develop_into UBERON:0005721 ! pronephric mesoderm +[Term] +id: UBERON:0007298 +name: pronephric proximal convoluted tubule +is_a: UBERON:0001287 ! proximal convoluted tubule +is_a: UBERON:0005310 ! pronephric nephron tubule +intersection_of: UBERON:0001287 ! proximal convoluted tubule +intersection_of: part_of UBERON:0002120 ! pronephros + [Term] id: UBERON:0007300 name: pectoral appendage blood vessel @@ -280366,11 +393341,29 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000026 ! appendage relationship: part_of UBERON:0000026 ! appendage +[Term] +id: UBERON:0007306 +name: pronephric glomerular capillary +is_a: UBERON:0004212 ! glomerular capillary +intersection_of: UBERON:0004212 ! glomerular capillary +intersection_of: part_of UBERON:0002120 ! pronephros +relationship: part_of UBERON:0004739 ! pronephric glomerulus +relationship: part_of UBERON:0005309 ! pronephric nephron + +[Term] +id: UBERON:0007307 +name: pronephric glomerular basement membrane +is_a: UBERON:0005777 ! glomerular basement membrane +intersection_of: UBERON:0005777 ! glomerular basement membrane +intersection_of: part_of UBERON:0002120 ! pronephros +relationship: part_of UBERON:0004739 ! pronephric glomerulus + [Term] id: UBERON:0007324 name: pancreatic lobule namespace: uberon def: "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." [ISBN:0123813611] +subset: human_reference_atlas synonym: "lobulus pancreaticus" EXACT [FMA:16012] synonym: "pancreas lobe" EXACT [MA:0000721] synonym: "pancreatic lobule" EXACT [FMA:16012] @@ -280379,8 +393372,11 @@ xref: FMA:16012 xref: MA:0000721 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure +relationship: has_part UBERON:0001263 ! pancreatic acinus +relationship: has_part UBERON:0014719 ! intralobular duct relationship: part_of UBERON:0000017 ! exocrine pancreas property_value: editor_note "TODO - check" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000008 "In mice many lobules lack islets, in contrast to other mammals including humans" xsd:string [Term] @@ -280388,6 +393384,7 @@ id: UBERON:0007329 name: pancreatic duct namespace: uberon def: "A duct that collects and carries secretions of the exocrine pancreas to the intestine." [GOC:cvs, GOC:ymb, https://github.com/obophenotype/uberon/issues/1250, https://orcid.org/0000-0002-2244-7917, https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-9900-7880, Wikipedia:Pancreatic_duct] +subset: human_reference_atlas subset: pheno_slim subset: vertebrate_core synonym: "duct of pancreas" EXACT [OBOL:accepted] @@ -280397,6 +393394,7 @@ xref: EHDAA:9194 xref: EMAPA:32952 xref: FMA:10419 xref: MA:0000124 +xref: MESH:D010183 xref: SCTID:181278006 xref: TAO:0001372 xref: VHOG:0000254 @@ -280404,14 +393402,37 @@ xref: Wikipedia:Pancreatic_duct xref: ZFA:0001372 is_a: UBERON:0003928 {source="ZFA"} ! digestive system duct is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: connected_to UBERON:0000160 ! intestine +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: connected_to UBERON:0000160 ! intestine +relationship: contributes_to_morphology_of UBERON:0000017 ! exocrine pancreas relationship: develops_from UBERON:0003922 ! pancreatic epithelial bud relationship: part_of UBERON:0000017 {source="MA"} ! exocrine pancreas property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png xsd:anyURI property_value: IAO:0000232 "this class groups together accessory (dorsal) and main (ventral) pancreatic ducts" xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000254", ontology="VHOG", source="http://bgee.unil.ch/"} property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000254", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000012 "in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms" xsd:string {external_ontology="EHDAA2"} +[Term] +id: UBERON:0007354 +name: cartilage of pharyngotympanic tube +is_a: UBERON:0007844 ! cartilage element +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: part_of UBERON:0002393 ! pharyngotympanic tube + +[Term] +id: UBERON:0007355 +name: bony part of pharyngotympanic tube +is_a: UBERON:0002481 ! bone tissue +is_a: UBERON:0003566 ! head connective tissue +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: part_of UBERON:0002393 ! pharyngotympanic tube + [Term] id: UBERON:0007356 name: crop @@ -280456,7 +393477,7 @@ xref: BTO:0000480 is_a: UBERON:0011954 ! stomach non-glandular region relationship: develops_from UBERON:0001041 ! foregut relationship: part_of UBERON:0007366 ! ruminant stomach -property_value: depicted:by Abomasum:(PSF).png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png xsd:anyURI property_value: UBPROP:0000011 "You will still see the statement in some texts that the parts of the forestomach are derived from the embryonic esophagus, and that's the reason why (like the esophagus) they're lined with stratified squamous epithelium. This is open to doubt. While there is no doubt that the rumen, reticulum, and omasum are all derived from the embryonic foregut, there is evidence to indicate that all three come from that an area of the foregut homologous to the part that develops into the single stomach of non-ruminants. If this is so, then the forestomach can be considered diverticula (or derivatives) of the stomach proper, not the esophagus, despite the nature of the lining -- http://www.vetmed.vt.edu/education/curriculum/vm8054/labs/lab21/Examples/exrumen.htm" xsd:string [Term] @@ -280475,7 +393496,7 @@ xref: Wikipedia:Omasum is_a: UBERON:0011954 ! stomach non-glandular region relationship: part_of UBERON:0007359 ! ruminant forestomach relationship: part_of UBERON:0007364 ! reticulorumen -property_value: depicted:by Abomasum:(PSF).png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png xsd:anyURI property_value: UBPROP:0000007 "omasal" xsd:string [Term] @@ -280504,7 +393525,7 @@ xref: Wikipedia:Rumen is_a: UBERON:0011954 ! stomach non-glandular region relationship: part_of UBERON:0007359 ! ruminant forestomach relationship: part_of UBERON:0007364 ! reticulorumen -property_value: depicted:by Abomasum:(PSF).png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png xsd:anyURI property_value: UBPROP:0000007 "ruminal" xsd:string property_value: UBPROP:0000009 "Coarse, partially chewed food is stored and churned in the rumen until the animal finds circumstances convenient for rumination. When this occurs, little balls of food are regurgitated through the esophagus into the mouth, and are subjected to a second more thorough mastication, swallowed, and passed on into other parts of the compound stomach. (From Black's Veterinary Dictionary, 17th ed)" xsd:string property_value: UBPROP:0000010 "There is no muscularis mucosae in the rumen. The rumen is lined by mucous membrane containing no digestive glands, but mucus-secreting glands are present in large numbers" xsd:string @@ -280518,7 +393539,7 @@ synonym: "plurilocular stomach" RELATED [] xref: GAID:1240 xref: MESH:D013279 is_a: UBERON:0000945 ! stomach -property_value: depicted:by Abomasum:(PSF).png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png xsd:anyURI property_value: editor_note "Consider classifying each subdivision as 'stomach chamber'" xsd:string [Term] @@ -280535,6 +393556,22 @@ intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: bounding_layer_of UBERON:0001723 ! tongue relationship: bounding_layer_of UBERON:0001723 ! tongue +[Term] +id: UBERON:0007371 +name: superior surface of tongue +is_a: UBERON:0007367 ! surface of tongue +intersection_of: UBERON:0007367 ! surface of tongue +intersection_of: BSPO:0015101 UBERON:0001723 ! tongue +relationship: BSPO:0015101 UBERON:0001723 ! tongue + +[Term] +id: UBERON:0007373 +name: inferior surface of tongue +is_a: UBERON:0007367 ! surface of tongue +intersection_of: UBERON:0007367 ! surface of tongue +intersection_of: BSPO:0015102 UBERON:0001723 ! tongue +relationship: BSPO:0015102 UBERON:0001723 ! tongue + [Term] id: UBERON:0007374 name: incus cartilage element @@ -280611,6 +393648,31 @@ property_value: UBPROP:0000001 "Outermost monolayer of cells surrounding the emb property_value: UBPROP:0000002 "relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000086", ontology="TAO"} property_value: UBPROP:0000008 "Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm." xsd:string +[Term] +id: UBERON:0007384 +name: appendage lymph vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0004708 ! paired limb/fin +relationship: part_of UBERON:0004708 ! paired limb/fin +relationship: part_of UBERON:0007304 ! appendage vasculature + +[Term] +id: UBERON:0007385 +name: pectoral appendage lymph vessel +is_a: UBERON:0007384 ! appendage lymph vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0004710 ! pectoral appendage +relationship: part_of UBERON:0007302 ! pectoral appendage vasculature + +[Term] +id: UBERON:0007386 +name: pelvic appendage lymph vessel +is_a: UBERON:0007384 ! appendage lymph vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0004709 ! pelvic appendage +relationship: part_of UBERON:0004709 ! pelvic appendage + [Term] id: UBERON:0007389 name: paired limb/fin cartilage @@ -280638,6 +393700,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0004710 ! pectoral appendage +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0007272 ! pectoral appendage skeleton property_value: UBPROP:0000001 "Cartilage which is part of the pectoral fin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000257", ontology="TAO", source="ZFIN:curator"} @@ -280653,6 +393716,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: part_of UBERON:0004709 ! pelvic appendage +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0007273 ! pelvic appendage skeleton property_value: UBPROP:0000001 "Cartilage which is part of the pelvic fin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001459", ontology="TAO", source="ZFIN:curator"} @@ -280682,10 +393746,10 @@ synonym: "cerebellum peduncle" RELATED [EMAPA:35213] xref: BAMS:cbp xref: EMAPA:35213 xref: FMA:272298 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1207 xref: MA:0002742 xref: MBA:752 xref: NCIT:C88147 +xref: neuronames:1207 xref: SCTID:362417003 xref: UMLS:C0228515 {source="ncithesaurus:Cerebellar_Peduncle"} is_a: UBERON:0007417 {source="FMA"} ! peduncle of neuraxis @@ -280728,6 +393792,8 @@ def: "A neural decussation that is part of a diencephalon." [OBOL:automatic] synonym: "diencephalon decussation" EXACT [FMA:62446] xref: FMA:62446 is_a: UBERON:0007418 {source="FMA"} ! neural decussation +intersection_of: UBERON:0007418 ! neural decussation +intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 {source="Obol"} ! diencephalon [Term] @@ -280749,16 +393815,23 @@ relationship: part_of UBERON:0007499 ! epithelial sac id: UBERON:0007475 name: matrix-based tissue namespace: uberon -alt_id: EHDAA2:0003081 def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB] xref: AEO:0000081 xref: EHDAA2:0003081 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: composed_primarily_of GO:0031012 ! extracellular matrix relationship: composed_primarily_of GO:0031012 ! extracellular matrix +[Term] +id: UBERON:0007490 +name: keratin-based acellular structure +is_a: UBERON:0000476 ! acellular anatomical structure +intersection_of: UBERON:0000476 ! acellular anatomical structure +intersection_of: composed_primarily_of GO:0045095 ! keratin filament +relationship: composed_primarily_of GO:0045095 ! keratin filament +relationship: has_quality PATO:0002507 ! keratinous + [Term] id: UBERON:0007499 name: epithelial sac @@ -280768,6 +393841,8 @@ xref: AEO:0000115 xref: EHDAA2:0003115 is_a: UBERON:0003914 {source="AEO"} ! epithelial tube is_a: UBERON:0009856 ! sac +intersection_of: UBERON:0000483 ! epithelium +intersection_of: has_quality PATO:0001987 ! saccular [Term] id: UBERON:0007500 @@ -280778,6 +393853,12 @@ xref: AEO_RETIRED:0000116 xref: RETIRED_EHDAA2:0003116 is_a: UBERON:0003914 {source="AEO"} ! epithelial tube +[Term] +id: UBERON:0007501 +name: arborizing epithelial duct system +is_a: UBERON:0007499 ! epithelial sac +relationship: has_part UBERON:0003914 ! epithelial tube + [Term] id: UBERON:0007503 name: epithelial vesicle @@ -280797,6 +393878,23 @@ xref: AEO:0000143 xref: EHDAA2:0003143 xref: SCTID:362915001 is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: has_part CL:0000192 ! smooth muscle cell +relationship: composed_primarily_of UBERON:0001135 ! smooth muscle tissue +relationship: has_part CL:0000192 ! smooth muscle cell + +[Term] +id: UBERON:0007522 +name: striated muscle sphincter +namespace: uberon +def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB] +xref: AEO:0000144 +xref: EHDAA2:0003144 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: has_part CL:0000737 ! striated muscle cell +relationship: composed_primarily_of UBERON:0002036 ! striated muscle tissue +relationship: has_part CL:0000737 ! striated muscle cell [Term] id: UBERON:0007524 @@ -280814,11 +393912,12 @@ relationship: has_part CL:0000057 {source="AEO"} ! fibroblast id: UBERON:0007529 name: loose mesenchyme tissue namespace: uberon -alt_id: EHDAA2:0003151 def: "Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix." [AEO:JB] xref: AEO:0000151 xref: EHDAA2:0003151 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0003104 {source="AEO"} ! mesenchyme +relationship: has_part CL:0000057 ! fibroblast [Term] id: UBERON:0007530 @@ -280839,14 +393938,31 @@ id: UBERON:0007589 name: ciliated columnar oviduct epithelium namespace: uberon def: "A ciliated columnar epithelium that is part of a oviduct." [OBOL:automatic] +subset: human_reference_atlas synonym: "epithelium of uterine tube" RELATED [FMA:62016] synonym: "uterine tube epithelium" RELATED [FMA:62016] xref: FMA:62016 xref: MA:0001719 is_a: UBERON:0004804 {source="MA"} ! oviduct epithelium is_a: UBERON:0007592 {source="FMA"} ! ciliated columnar epithelium +intersection_of: UBERON:0007592 ! ciliated columnar epithelium +intersection_of: part_of UBERON:0000993 ! oviduct +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0007590 +name: cuboidal oviduct epithelium +namespace: uberon +def: "A cuboidal epithelium that is part of a oviduct." [OBOL:automatic] +subset: human_reference_atlas +xref: MA:0001720 +is_a: UBERON:0004804 {source="MA"} ! oviduct epithelium +is_a: UBERON:0010077 ! cuboidal epithelium +intersection_of: UBERON:0010077 ! cuboidal epithelium +intersection_of: part_of UBERON:0000993 ! oviduct +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0007592 name: ciliated columnar epithelium @@ -280870,6 +393986,20 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: has_part CL:0000067 ! ciliated epithelial cell relationship: has_part CL:0000067 ! ciliated epithelial cell +[Term] +id: UBERON:0007602 +name: stratified columnar epithelium +is_a: UBERON:0000486 ! multilaminar epithelium +is_a: UBERON:0012274 ! columnar epithelium + +[Term] +id: UBERON:0007606 +name: ciliated stratified columnar epithelium +is_a: UBERON:0007601 ! ciliated epithelium +is_a: UBERON:0007602 ! stratified columnar epithelium +intersection_of: UBERON:0007602 ! stratified columnar epithelium +intersection_of: has_part CL:0000067 ! ciliated epithelial cell + [Term] id: UBERON:0007615 name: prostate gland ventral lobe @@ -280896,7 +394026,6 @@ synonym: "synovium" EXACT [CALOHA:TS-0998] xref: BTO:0001338 xref: CALOHA:TS-0998 xref: FMA:66762 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: produces UBERON:0001090 ! synovial fluid @@ -280959,9 +394088,9 @@ synonym: "lateral septum complex" RELATED [BAMS:LSX] xref: BAMS:LSX xref: BTO:0003937 xref: EMAPA:35485 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2672 xref: MA:0000933 xref: MBA:275 +xref: neuronames:2672 is_a: UBERON:0002663 {source="MA"} ! septal nuclear complex relationship: part_of UBERON:0002435 {source="ABA"} ! striatum @@ -280985,11 +394114,11 @@ namespace: uberon def: "Layer of the hippocampus lying just superficial to the stratum radiatum and bounded by the pial surface of the hippocampus. The fibers of the perforant pathway fibers from entorhinal cortex and several other brain areas terminate in this layer. Adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995, pg. 460)." [BIRNLEX:1359] synonym: "lacunar-molecular layer of hippocampus" EXACT [FMA:83149] synonym: "stratum hippocampi moleculare et substratum lacunosum" EXACT LATIN [FMA:83149, FMA:TA] -synonym: "stratum lacunosum moleculare" EXACT [BIRNLEX:1359, http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2456] +synonym: "stratum lacunosum moleculare" EXACT [BIRNLEX:1359, neuronames:2456] synonym: "stratum lacunosum-moleculare" EXACT [ABA:ABA] xref: BIRNLEX:1359 xref: FMA:83149 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2456 {source="https://github.com/obophenotype/uberon/issues/1223"} +xref: neuronames:2456 {source="https://github.com/obophenotype/uberon/issues/1223"} is_a: UBERON:0002305 ! layer of hippocampus property_value: UBPROP:0000010 "Here the perforant path fibers form synapses onto the distal, apical dendrites of pyramidal cells.[WP]" xsd:string @@ -281006,7 +394135,7 @@ xref: CALOHA:TS-2077 xref: DHBA:266441713 xref: FMA:71248 xref: HBA:9203 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2021 +xref: neuronames:2021 xref: UMLS:C0040999 {source="BIRNLEX:4096"} xref: Wikipedia:Trigeminal_nerve_nuclei is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis @@ -281015,6 +394144,14 @@ relationship: overlaps UBERON:0003023 {source="FMA"} ! pontine tegmentum property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png xsd:anyURI property_value: UBPROP:0000012 "in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate." xsd:string {external_ontology="MA"} +[Term] +id: UBERON:0007644 +name: thoracic lymph node +is_a: UBERON:0000029 ! lymph node +is_a: UBERON:0005181 ! thoracic segment organ +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk + [Term] id: UBERON:0007645 name: future meninx @@ -281044,7 +394181,10 @@ def: "The innermost layer of the mesenchymal capsule that surrounds the developi synonym: "future leptomeninges" EXACT [] synonym: "future leptomeninx" EXACT [] is_a: UBERON:0007645 ! future meninx +intersection_of: UBERON:0007645 ! future meninx +intersection_of: has_potential_to_develop_into UBERON:0000391 ! leptomeninx relationship: develops_from UBERON:0007213 {source="ISBN:9781607950325"} ! mesenchyme derived from head neural crest +relationship: has_potential_to_develop_into UBERON:0000391 ! leptomeninx [Term] id: UBERON:0007647 @@ -281075,6 +394215,18 @@ xref: SCTID:91833003 is_a: UBERON:0000061 {source="FMA"} ! anatomical structure relationship: connects UBERON:0000061 {minCardinality="2"} ! anatomical structure +[Term] +id: UBERON:0007652 +name: esophageal sphincter +namespace: uberon +def: "A sphincter that is part of an esophagus." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:277765007 +is_a: UBERON:0003832 ! esophagus muscle +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0001043 ! esophagus +property_value: editor_note "check for specific subtypes across species. Note mammals have upper and lower, but lower is really part of cardia and thus is not classified under here" xsd:string + [Term] id: UBERON:0007679 name: intersomitic vein @@ -281101,6 +394253,8 @@ xref: FMA:17691 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube +relationship: has_part UBERON:0001232 ! collecting duct of renal tubule +relationship: has_part UBERON:0001285 ! nephron [Term] id: UBERON:0007685 @@ -281130,6 +394284,7 @@ relationship: has_potential_to_develop_into UBERON:0002113 ! kidney id: UBERON:0007688 name: anlage namespace: uberon +def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [FBbt:00005426, http://flybase.org/reports/FBrf0178740.html] def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [FBbt:00005426, http://flybase.org/reports/FBrf0178740.html, JB:DEF] subset: efo_slim synonym: "developmental field" EXACT [] @@ -281197,7 +394352,7 @@ intersection_of: UBERON:0000161 ! orifice intersection_of: part_of UBERON:0001727 ! taste bud relationship: continuous_with UBERON:0000167 ! oral cavity relationship: part_of UBERON:0001727 {source="FMA"} ! taste bud -property_value: depicted:by Taste:bud.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/0/0e/Taste_bud.svg xsd:anyURI [Term] id: UBERON:0007692 @@ -281213,6 +394368,8 @@ xref: MA:0002992 xref: SCTID:279115000 xref: Wikipedia:List_of_thalamic_nuclei is_a: UBERON:0006569 ! diencephalic nucleus +intersection_of: UBERON:0002308 ! nucleus of brain +intersection_of: part_of UBERON:0001897 ! dorsal plus ventral thalamus relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus property_value: editor_note "TODO - consider splitting nucleus and complex" xsd:string @@ -281226,6 +394383,8 @@ xref: FMA:75683 xref: NCIT:C12995 xref: UMLS:C1519456 {source="ncithesaurus:Spinal_Cord_Tract"} is_a: UBERON:0001018 ! axon tract +intersection_of: UBERON:0001018 ! axon tract +intersection_of: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002240 ! spinal cord relationship: part_of UBERON:0002316 {source="cjm"} ! white matter @@ -281238,6 +394397,8 @@ synonym: "brain tract" EXACT [FMA:83848] synonym: "landmark tracts" RELATED [DMBA:tracts] xref: FMA:83848 is_a: UBERON:0001018 ! axon tract +intersection_of: UBERON:0001018 ! axon tract +intersection_of: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0000955 ! brain relationship: part_of UBERON:0002316 {source="cjm"} ! white matter property_value: editor_note "the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts" xsd:string @@ -281255,8 +394416,8 @@ synonym: "superior cerebellar peduncle of the pons" RELATED [NeuroNames:833] xref: BAMS:scpp xref: BIRNLEX:1726 xref: FMA:72495 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1007150190 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=833 {source="BIRNLEX:1726"} +xref: neuronames:1007150190 +xref: neuronames:833 {source="BIRNLEX:1726"} is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0002150 ! superior cerebellar peduncle @@ -281277,6 +394438,17 @@ intersection_of: part_of UBERON:0003133 ! reproductive organ relationship: part_of UBERON:0003133 ! reproductive organ property_value: RO:0002161 NCBITaxon:9606 {source="Wikipedia"} +[Term] +id: UBERON:0007721 +name: interphalangeal joint of pes +is_a: UBERON:0001487 ! pes joint +is_a: UBERON:0006658 ! interphalangeal joint +intersection_of: UBERON:0006658 ! interphalangeal joint +intersection_of: part_of UBERON:0001466 ! pedal digit +relationship: connects UBERON:0001449 {cardinality="2"} ! phalanx of pes +relationship: connects UBERON:0001449 ! phalanx of pes +relationship: part_of UBERON:0001466 ! pedal digit + [Term] id: UBERON:0007722 name: interphalangeal joint of manus @@ -281299,9 +394471,40 @@ xref: UMLS:C0016125 {source="ncithesaurus:Interphalangeal_Joint_of_the_Hand"} xref: Wikipedia:Interphalangeal_articulations_of_the_hand is_a: UBERON:0001489 ! manus joint is_a: UBERON:0006658 ! interphalangeal joint +intersection_of: UBERON:0006658 ! interphalangeal joint +intersection_of: part_of UBERON:0002389 ! manual digit +relationship: connects UBERON:0001436 {cardinality="2"} ! phalanx of manus +relationship: connects UBERON:0001436 ! phalanx of manus relationship: part_of UBERON:0002389 ! manual digit property_value: editor_note "consider renaming: 'finger' is ambiguous as the term in some usages excludes the thumb (we include it)" xsd:string +[Term] +id: UBERON:0007723 +name: interphalangeal joint of manual digit 1 +is_a: UBERON:0007722 ! interphalangeal joint of manus +intersection_of: UBERON:0007722 ! interphalangeal joint of manus +intersection_of: part_of UBERON:0001463 ! manual digit 1 +relationship: connects UBERON:0003620 {cardinality="2"} ! manual digit 1 phalanx +relationship: part_of UBERON:0001463 ! manual digit 1 + +[Term] +id: UBERON:0007724 +name: interphalangeal joint of pedal digit 1 +is_a: UBERON:0007721 ! interphalangeal joint of pes +intersection_of: UBERON:0007721 ! interphalangeal joint of pes +intersection_of: part_of UBERON:0003631 ! pedal digit 1 +relationship: connects UBERON:0003640 {cardinality="2"} ! pedal digit 1 phalanx +relationship: part_of UBERON:0003631 ! pedal digit 1 + +[Term] +id: UBERON:0007728 +name: interphalangeal joint of pedal digit 5 +is_a: UBERON:0007721 ! interphalangeal joint of pes +intersection_of: UBERON:0007721 ! interphalangeal joint of pes +intersection_of: part_of UBERON:0003635 ! pedal digit 5 +relationship: connects UBERON:0003863 {cardinality="2"} ! pedal digit 5 phalanx +relationship: part_of UBERON:0003635 ! pedal digit 5 + [Term] id: UBERON:0007732 name: interphalangeal joint of manual digit 5 @@ -281314,8 +394517,51 @@ synonym: "interphalangeal joint of manual digit V" EXACT COMPARATIVE_PREFERRED [ xref: EMAPA:25070 xref: FMA:35407 is_a: UBERON:0007722 ! interphalangeal joint of manus +intersection_of: UBERON:0007722 ! interphalangeal joint of manus +intersection_of: part_of UBERON:0003625 ! manual digit 5 +relationship: connects UBERON:0003863 {cardinality="2"} ! pedal digit 5 phalanx relationship: part_of UBERON:0003625 ! manual digit 5 +[Term] +id: UBERON:0007735 +name: metacarpophalangeal joint of manual digit 1 +is_a: UBERON:0003695 ! metacarpophalangeal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002374 ! metacarpal bone +intersection_of: connects UBERON:0004338 ! proximal phalanx of manual digit 1 +relationship: connects UBERON:0004338 ! proximal phalanx of manual digit 1 +relationship: part_of UBERON:0001463 ! manual digit 1 + +[Term] +id: UBERON:0007747 +name: metacarpophalangeal joint of manual digit 5 +is_a: UBERON:0003695 ! metacarpophalangeal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002374 ! metacarpal bone +intersection_of: connects UBERON:0004331 ! proximal phalanx of manual digit 5 +relationship: connects UBERON:0004331 ! proximal phalanx of manual digit 5 +relationship: part_of UBERON:0003625 ! manual digit 5 + +[Term] +id: UBERON:0007750 +name: metatarsophalangeal joint of pedal digit 1 +is_a: UBERON:0003696 ! metatarsophalangeal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001448 ! metatarsal bone +intersection_of: connects UBERON:0004315 ! distal phalanx of pedal digit 1 +relationship: connects UBERON:0004315 ! distal phalanx of pedal digit 1 +relationship: part_of UBERON:0003631 ! pedal digit 1 + +[Term] +id: UBERON:0007762 +name: metatarsophalangeal joint of pedal digit 5 +is_a: UBERON:0003696 ! metatarsophalangeal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001448 ! metatarsal bone +intersection_of: connects UBERON:0004319 ! distal phalanx of pedal digit 5 +relationship: connects UBERON:0004319 ! distal phalanx of pedal digit 5 +relationship: part_of UBERON:0003635 ! pedal digit 5 + [Term] id: UBERON:0007763 name: cerebellum vermis culmen @@ -281331,8 +394577,8 @@ xref: BAMS:CUL xref: BAMS:Cul xref: BIRNLEX:926 xref: FMA:83886 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=659 xref: MBA:928 +xref: neuronames:659 xref: SCTID:279384001 xref: SCTID:89649002 is_a: UBERON:0004070 {source="ABA"} ! cerebellum vermis lobule @@ -281364,6 +394610,25 @@ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0001003 ! skin epidermis relationship: part_of UBERON:0001003 ! skin epidermis +[Term] +id: UBERON:0007772 +name: scrotal sweat +is_a: UBERON:0001089 ! sweat +is_a: UBERON:0006536 ! male reproductive gland secretion +intersection_of: UBERON:0001089 ! sweat +intersection_of: produced_by UBERON:0007773 ! scrotal sweat gland +relationship: produced_by UBERON:0007773 ! scrotal sweat gland + +[Term] +id: UBERON:0007773 +name: scrotal sweat gland +is_a: UBERON:0001820 ! sweat gland +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005399 ! male reproductive gland +intersection_of: UBERON:0001820 ! sweat gland +intersection_of: part_of UBERON:0001300 ! scrotum +relationship: part_of UBERON:0001300 ! scrotum + [Term] id: UBERON:0007774 name: secondary dentition @@ -281379,7 +394644,7 @@ synonym: "set of permanent teeth" EXACT [FMA:75152] synonym: "set of secondary teeth" EXACT [FMA:75152] xref: FMA:75152 xref: GAID:1251 -xref: MESH:A14.254.237 +xref: MESH:D019229 is_a: UBERON:0003672 {source="FMA"} ! dentition [Term] @@ -281400,6 +394665,14 @@ is_a: UBERON:0001091 ! calcareous tooth relationship: part_of UBERON:0007774 ! secondary dentition property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg xsd:anyURI +[Term] +id: UBERON:0007778 +name: umbilical artery endothelium +is_a: UBERON:0001917 ! endothelium of artery +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0001310 ! umbilical artery +relationship: part_of UBERON:0001310 ! umbilical artery + [Term] id: UBERON:0007779 name: transudate @@ -281419,7 +394692,7 @@ intersection_of: has_quality PATO:0001548 ! quality of a liquid intersection_of: transformation_of UBERON:0001969 ! blood plasma relationship: develops_from UBERON:0001969 ! blood plasma relationship: filtered_through UBERON:0001982 ! capillary -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: transformation_of UBERON:0001969 ! blood plasma property_value: UBPROP:0000007 "transudative" xsd:string property_value: UBPROP:0000010 "characteristically low in protein and cellular content (unless there has been secondary concentration)" xsd:string @@ -281474,6 +394747,16 @@ is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure relationship: develops_from UBERON:0005728 {source="EHDAA2"} ! extraembryonic mesoderm property_value: editor_note "TODO - this is currently defined as a bridge of mesoderm, but in EHDAA2 is extraembryonic structure split into mesoderm and blood vessels" xsd:string +[Term] +id: UBERON:0007807 +name: connecting stalk vasculature +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0007806 ! connecting stalk +relationship: develops_from UBERON:0011921 ! connecting stalk blood islands +relationship: part_of UBERON:0007806 ! connecting stalk + [Term] id: UBERON:0007808 name: adipose tissue of abdominal region @@ -281543,6 +394826,10 @@ xref: UMLS:C0039259 {source="ncithesaurus:Tail"} xref: XAO:0003026 xref: ZFA:0001117 is_a: UBERON:0002415 ! tail +intersection_of: UBERON:0002415 ! tail +intersection_of: part_of UBERON:0006071 ! caudal region +relationship: capable_of_part_of GO:0007626 ! locomotory behavior +relationship: only_in_taxon NCBITaxon:7711 ! Chordata relationship: part_of UBERON:0006071 ! caudal region relationship: transformation_of UBERON:0007144 ! embryonic post-anal tail property_value: RO:0002161 NCBITaxon:314295 @@ -281565,15 +394852,32 @@ synonym: "limb girdle region" RELATED SENSU [] xref: EMAPA:37854 {source="MA:th"} xref: FMA:24874 xref: VSAO:0000303 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: has_skeleton UBERON:0010719 ! girdle skeleton relationship: has_skeleton UBERON:0010719 ! girdle skeleton +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0010707 ! appendage girdle complex property_value: IAO:0000232 "this encompasses non-skeletal tissue" xsd:string property_value: UBPROP:0000001 "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000303", ontology="VSAO", source="https://orcid.org/0000-0002-6601-2165"} property_value: UBPROP:0000001 "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). There are only two instances of appendage girdle regions per organism.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000303", ontology="VSAO", source="https://orcid.org/0000-0002-6601-2165"} +[Term] +id: UBERON:0007826 +name: peritoneal mesentery +namespace: uberon +def: "Mesentery that is located in the peritoneum." [UBERON:cjm] +xref: FMA:20570 +xref: TAO:0005129 +xref: XAO:0000138 +xref: ZFA:0005129 +is_a: UBERON:0002095 ! mesentery +is_a: UBERON:0002358 ! peritoneum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0002358 ! peritoneum +relationship: part_of UBERON:0001178 {source="FMA"} ! visceral peritoneum + [Term] id: UBERON:0007827 name: external nose @@ -281588,6 +394892,10 @@ xref: SCTID:265785009 xref: UMLS:C0458561 {source="ncithesaurus:External_Nose"} is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034929 ! external soft tissue zone +intersection_of: UBERON:0034929 ! external soft tissue zone +intersection_of: has_part UBERON:0005928 ! external naris +intersection_of: part_of UBERON:0000004 ! nose +relationship: has_part UBERON:0005928 ! external naris relationship: part_of UBERON:0000004 ! nose property_value: UBPROP:0000001 "Subdivision of face, the exterior of the nose, which consists of a root, dorsum, tip, columella, and right and left alae[FMA:59515]." xsd:string {source="FMA:59515"} @@ -281866,6 +395174,24 @@ intersection_of: UBERON:0001474 ! bone element intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0007811 {source="MA"} ! craniocervical region +[Term] +id: UBERON:0007997 +name: sesamoid bone of manus +is_a: UBERON:0001479 ! sesamoid bone +is_a: UBERON:0005897 ! manus bone +is_a: UBERON:0011141 ! appendicular ossicle +intersection_of: UBERON:0001479 ! sesamoid bone +intersection_of: part_of UBERON:0002398 ! manus + +[Term] +id: UBERON:0008000 +name: sesamoid bone of pes +is_a: UBERON:0001479 ! sesamoid bone +is_a: UBERON:0005899 ! pes bone +is_a: UBERON:0011141 ! appendicular ossicle +intersection_of: UBERON:0001479 ! sesamoid bone +intersection_of: part_of UBERON:0002387 ! pes + [Term] id: UBERON:0008001 name: irregular bone @@ -281892,6 +395218,7 @@ is_a: UBERON:0000982 {source="MA"} ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: part_of UBERON:0007823 ! appendage girdle region relationship: connects UBERON:0007828 ! girdle bone/zone +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0007823 ! appendage girdle region [Term] @@ -281909,6 +395236,24 @@ intersection_of: bounding_layer_of UBERON:0007844 ! cartilage element relationship: bounding_layer_of UBERON:0007844 ! cartilage element relationship: part_of UBERON:0007844 ! cartilage element +[Term] +id: UBERON:0008188 +name: tendon of biceps brachii +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0000043 ! tendon +intersection_of: UBERON:0000043 ! tendon +intersection_of: attaches_to UBERON:0001507 ! biceps brachii +relationship: attaches_to UBERON:0001507 ! biceps brachii + +[Term] +id: UBERON:0008192 +name: tendon of triceps brachii +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0000043 ! tendon +intersection_of: UBERON:0000043 ! tendon +intersection_of: attaches_to UBERON:0001509 ! triceps brachii +relationship: attaches_to UBERON:0001509 ! triceps brachii + [Term] id: UBERON:0008193 name: pneumatized bone @@ -281950,6 +395295,8 @@ synonym: "pectoral girdle muscle" EXACT [FMA:37347] xref: EMAPA:17748 xref: FMA:37347 is_a: UBERON:0010891 ! pectoral complex muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0001421 ! pectoral girdle region relationship: part_of UBERON:0004471 ! musculature of pectoral girdle property_value: UBPROP:0000012 "EMAPA has both non-skeletal and skeletal types, with the non-skeletal also including a chest muscle, so we place the skeletal class here as the most accurate" xsd:string {external_ontology="EMAPA"} @@ -282015,6 +395362,7 @@ xref: FMA:42854 xref: MA:0000655 xref: SCTID:304907005 is_a: UBERON:0001474 ! bone element +relationship: overlaps UBERON:0001464 ! hip property_value: editor_note "todo - consider obsoletion" xsd:string property_value: UBPROP:0000012 "in MA, this includes the femur. i.e. pelvic girdle bone or femur; note that this makes the ilium etc in MA hindlimb bones. in MA this is a hindlimb bone" xsd:string {external_ontology="MA"} @@ -282023,6 +395371,7 @@ id: UBERON:0008203 name: pelvic cavity namespace: uberon def: "The part of the ventral body cavity that is within the pelvis." [UBERON:cjm] +synonym: "cavitas pelvis" RELATED LATIN [Wikipedia:Pelvic_cavity] synonym: "cavitas pelvis" RELATED LATIN [http://en.wikipedia.org/wiki/Pelvic_cavity] synonym: "space of pelvic compartment" EXACT [FMA:9738] xref: EMAPA:37235 {source="MA:th"} @@ -282030,6 +395379,8 @@ xref: FMA:9738 xref: http://www.snomedbrowser.com/Codes/Details/281903009 xref: MA:0003089 xref: Pelvic:cavity +xref: SCTID:281903009 +xref: Wikipedia:Pelvic_cavity is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002553 ! anatomical cavity @@ -282093,6 +395444,15 @@ relationship: part_of UBERON:0000915 {source="MA"} ! thoracic segment of trunk relationship: part_of UBERON:0000915 {source="FMA"} ! thoracic segment of trunk relationship: part_of UBERON:0011270 {source="FMA"} ! dorsal trunk +[Term] +id: UBERON:0008242 +name: lower back muscle +is_a: UBERON:0002324 ! muscle of back +is_a: UBERON:0003833 ! abdominal segment muscle +intersection_of: UBERON:0002324 ! muscle of back +intersection_of: part_of UBERON:0005462 ! lower back +relationship: part_of UBERON:0005462 ! lower back + [Term] id: UBERON:0008243 name: upper back muscle @@ -282107,6 +395467,22 @@ intersection_of: UBERON:0002324 ! muscle of back intersection_of: part_of UBERON:0008231 ! dorsal thoracic segment of trunk relationship: part_of UBERON:0008231 {source="MA"} ! dorsal thoracic segment of trunk +[Term] +id: UBERON:0008255 +name: right clavicle +is_a: UBERON:0001105 ! clavicle bone +intersection_of: UBERON:0001105 ! clavicle bone +intersection_of: in_right_side_of UBERON:0002091 ! appendicular skeleton +relationship: in_right_side_of UBERON:0002091 ! appendicular skeleton + +[Term] +id: UBERON:0008256 +name: left clavicle +is_a: UBERON:0001105 ! clavicle bone +intersection_of: UBERON:0001105 ! clavicle bone +intersection_of: in_left_side_of UBERON:0002091 ! appendicular skeleton +relationship: in_left_side_of UBERON:0002091 ! appendicular skeleton + [Term] id: UBERON:0008266 name: periodontal ligament @@ -282138,13 +395514,16 @@ xref: EMAPA:35679 xref: FMA:56665 xref: GAID:1259 xref: MA:0002467 +xref: MESH:D010513 xref: SCTID:245775004 xref: Wikipedia:Periodontal_fiber is_a: UBERON:0008846 {source="FMA-moved"} ! skeletal ligament is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0001758 ! periodontium relationship: develops_from UBERON:0008969 {source="PMID:19767574", source="Wikipedia:Dental_follicle"} ! dental follicle relationship: part_of UBERON:0001758 {source="BTO"} ! periodontium -property_value: depicted:by The:Periodontium.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg xsd:anyURI property_value: seeAlso FMA:76870 property_value: UBPROP:0000001 "The collagen fibers, running from the cementum to the alveolar bone, that suspend a tooth in its socket; they include apical, oblique, horizontal, and alveolar crest fibers, indicating that the orientation of the fibers varies at different levels[http://www.drugs.com/dict/desmodentium.html]." xsd:string {source="http://www.drugs.com/dict/desmodentium.html"} property_value: UBPROP:0000001 "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. It consist of cells, extracellular compartment of fibers. The cells are fibroblast, epithelial, undifferentiated mesenchymal cells, bone and cementum cells. The extracellular compartment consists of collagen fibers bundles embedded in ground substance. The PDL substance has been estimated to be 70% water and is thought to have a significant effect on the tooth's ability to withstand stress loads[WP][BTO:0001020, Wikipedia:Periodontal_fiber, https://github.com/obophenotype/uberon/issues/21]." xsd:string {source="Wikipedia:Periodontal_fiber"} @@ -282165,6 +395544,7 @@ name: nacre namespace: uberon def: "An organic-inorganic composite material produced by some mollusks as an inner shell layer; it is also what makes up pearls. It is very strong, resilient, and iridescent. Nacre is found in some ancient lineages of bivalve gastropod and cephalopod. The inner layer in the great majority of mollusk shells is porcellaneous, not nacreous, frequently resulting in a non-iridescent shine or less commonly in non-nacreous iridescence such as flame structure (e.g. conch pearl). Pearls and the inside layer of pearl oyster and freshwater pearl mussel shells are made of nacre. Many other families of mollusk also have a nacreous inner shell layer, including marine gastropods such as the Haliotidae, the Trochidae and the Turbinidae. Nacre is composed of hexagonal platelets of aragonite (a form of calcium carbonate) 10-20 µm wide and 0.5 µm thick arranged in a continuous parallel lamina. These layers are separated by sheets of organic matrix composed of elastic biopolymers (such as chitin, lustrin and silk-like proteins)[WP]." [Wikipedia:Nacre] synonym: "mother of pearl" EXACT [Wikipedia:Nacre] +xref: MESH:D060734 xref: Wikipedia:Nacre is_a: UBERON:0000463 ! organism substance is_a: UBERON:0004755 ! skeletal tissue @@ -282213,13 +395593,14 @@ synonym: "dental germ" EXACT [http://medical-dictionary.thefreedictionary.com/to synonym: "tooth germ" EXACT [Wikipedia:Tooth_development] xref: BTO:0001838 xref: FMA:306006 -xref: MESH:A14.254.900.720 +xref: MESH:D014083 xref: NCIT:C34313 xref: SCTID:53301001 xref: UMLS:C0040442 {source="ncithesaurus:Tooth_Bud"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005423 ! developing anatomical structure relationship: develops_from UBERON:0005087 ! tooth placode +relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! jaw region [Term] id: UBERON:0008283 @@ -282252,6 +395633,15 @@ intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart property_value: IAO:0000232 "this class includes any endothelia that are part of the heart. This might include the endocardial epithelia, as well as endothelia of vessels that are considered strictly part of the heart (e.g. outflow tract). As a grouping class, this may lack utility, and pending review this class may be obsoleted. For annotation consider a more specific class." xsd:string +[Term] +id: UBERON:0008310 +name: nasopharyngeal gland +is_a: UBERON:0003295 ! pharyngeal gland +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx + [Term] id: UBERON:0008324 name: erectile tissue @@ -282260,6 +395650,7 @@ def: "With numerous vascular spaces that may become engorged with blood." [Wikip comment: Examples: corpus cavernosum or penis or clitoris xref: Wikipedia:Erectile_tissue is_a: UBERON:0000479 ! tissue +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0008330 @@ -282273,8 +395664,8 @@ synonym: "vaginal introitus" RELATED [BTO:0003145] synonym: "vaginal vestibule" EXACT [FMA:19970, MP:0011848] synonym: "vestibule of vagina" EXACT [FMA:19970, MP:0011848] synonym: "vestibule of vagina" RELATED [BTO:0003145] -synonym: "vestibulum pudendi" EXACT [MP:0011848] -synonym: "vestibulum pudendi" RELATED [BTO:0003145] +synonym: "vestibulum pudendi" EXACT DEPRECATED [BTO:0003145] +synonym: "vestibulum pudendi" EXACT DEPRECATED [MP:0011848] synonym: "vestibulum vaginae" EXACT LATIN [MP:0011848, Wikipedia:Vulval_vestibule] xref: BTO:0003145 xref: FMA:19970 @@ -282284,6 +395675,15 @@ is_a: UBERON:0001349 {source="FMA"} ! externally connecting tube lumen relationship: part_of UBERON:0000997 {source="BTO"} ! mammalian vulva property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/f3/Scheidenvorhof.jpg xsd:anyURI +[Term] +id: UBERON:0008331 +name: clitoral smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002411 ! clitoris +relationship: part_of UBERON:0002411 ! clitoris + [Term] id: UBERON:0008337 name: inguinal part of abdomen @@ -282306,7 +395706,7 @@ xref: EFO:0001397 xref: FMA:24040 xref: GAID:27 xref: galen:InguinalRegion -xref: MESH:A01.047.365 +xref: MESH:D006119 xref: NCIT:C12726 xref: SCTID:243962005 xref: UMLS:C0018246 {source="ncithesaurus:Inguinal_Region"} @@ -282341,6 +395741,8 @@ xref: UMLS:C0230463 {source="ncithesaurus:Plantar_Region"} xref: Wikipedia:Sole_(foot) is_a: UBERON:0005445 {source="FMA"} ! segment of pes is_a: UBERON:0008837 ! palmar/plantar part of autopod +intersection_of: UBERON:0008837 ! palmar/plantar part of autopod +intersection_of: part_of UBERON:0002387 ! pes property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/4/41/Soles2.jpg xsd:anyURI property_value: UBPROP:0000008 "In humans is the sole of the foot anatomically referred to as the plantar aspect. The equivalent surface in ungulates is the hoof" xsd:string @@ -282349,7 +395751,11 @@ id: UBERON:0008339 name: microvascular endothelium namespace: uberon xref: BTO:0003122 -is_a: UBERON:0004852 {source="BTO"} ! cardiovascular system endothelium +is_a: UBERON:0004638 ! blood vessel endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:8410081 ! blood microvessel +relationship: part_of UBERON:8410081 ! blood microvessel +property_value: seeAlso https://github.com/obophenotype/uberon/issues/2186 xsd:string [Term] id: UBERON:0008340 @@ -282386,6 +395792,8 @@ namespace: uberon def: "An intestinal villus in the duodenum." [OBOL:automatic] xref: FMA:63300 is_a: UBERON:0001213 ! intestinal villus +intersection_of: UBERON:0001213 ! intestinal villus +intersection_of: part_of UBERON:0002114 ! duodenum relationship: part_of UBERON:0000320 ! duodenal mucosa [Term] @@ -282395,6 +395803,8 @@ namespace: uberon def: "An intestinal villus in the jejunum." [OBOL:automatic] xref: FMA:63301 is_a: UBERON:0001213 ! intestinal villus +intersection_of: UBERON:0001213 ! intestinal villus +intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0000399 ! jejunal mucosa [Term] @@ -282404,8 +395814,44 @@ namespace: uberon def: "An intestinal villus in the ileum." [OBOL:automatic] xref: FMA:63302 is_a: UBERON:0001213 ! intestinal villus +intersection_of: UBERON:0001213 ! intestinal villus +intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0000331 ! ileal mucosa +[Term] +id: UBERON:0008345 +name: ileal epithelium +is_a: UBERON:0013636 ! epithelium of intestinal villus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002116 ! ileum +relationship: part_of UBERON:0008344 ! intestinal villus of ileum + +[Term] +id: UBERON:0008346 +name: duodenal epithelium +namespace: uberon +def: "An epithelium that is part of a duodenum." [OBOL:automatic] +subset: human_reference_atlas +synonym: "epithelium of duodenum" EXACT [FMA:17231] +xref: CALOHA:TS-2087 +xref: EMAPA:19078 +xref: FMA:17231 +xref: MA:0003208 +xref: SCTID:66036002 +is_a: UBERON:0013636 ! epithelium of intestinal villus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0008342 {source="FMA"} ! intestinal villus of duodenum +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0008367 +name: breast epithelium +is_a: UBERON:0000483 ! epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000310 ! breast +relationship: part_of UBERON:0000310 ! breast + [Term] id: UBERON:0008397 name: tracheobronchial epithelium @@ -282415,8 +395861,28 @@ synonym: "bronchotracheal epithelium" RELATED [BTO:0002925] xref: BTO:0002925 xref: CALOHA:TS-1063 is_a: UBERON:0004815 ! lower respiratory tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree +[Term] +id: UBERON:0008404 +name: proximal tubular epithelium +is_a: UBERON:0004810 ! nephron tubule epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: adjacent_to UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0004134 ! proximal tubule +relationship: part_of UBERON:0004134 ! proximal tubule + +[Term] +id: UBERON:0008408 +name: distal tubular epithelium +is_a: UBERON:0004810 ! nephron tubule epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: adjacent_to UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0004135 ! distal tubule +relationship: part_of UBERON:0004135 ! distal tubule + [Term] id: UBERON:0008424 name: inguinal mammary gland @@ -282426,6 +395892,8 @@ xref: MA:0000790 xref: SCTID:66519003 is_a: UBERON:0001911 ! mammary gland is_a: UBERON:0005173 ! abdominal segment element +intersection_of: UBERON:0001911 ! mammary gland +intersection_of: part_of UBERON:0008337 ! inguinal part of abdomen relationship: part_of UBERON:0008337 ! inguinal part of abdomen [Term] @@ -282441,12 +395909,60 @@ xref: EMAPA:18541 xref: Wikipedia:Milk_line is_a: UBERON:0006598 ! presumptive structure relationship: develops_from UBERON:0000924 ! ectoderm +relationship: has_potential_to_develop_into UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0000915 {gci_relation="part_of", gci_filler="NCBITaxon:9443"} ! thoracic segment of trunk relationship: part_of UBERON:0002100 ! trunk property_value: editor_note "consider splitting ridge (precursor) and milk line" xsd:string property_value: UBPROP:0000008 "These buds are either located in the thoracic region in primates, in the inguinal area in ungulates or along the entire length of the trunk in rodents and pigs. In humans, milk lines appear in the seventh week of embryonic development" xsd:string property_value: UBPROP:0000011 "in mouse, mammary gland development begins shortly after mid-gestation (about E10.5); epidermal cells within the milk line become columnar and multilayered, defining a ridge that protrudes above and below the plane of the single-layered primitive epidermis or periderm; by E11.5, five pairs of lens-shaped placodes form along the mammary line at the site of each future nipple.[MP]" xsd:string property_value: UBPROP:0000011 "The first manifestation of the mammary gland in many mammals is an elevated ridge or milk line, which then fragments into individual buds in specific regions lateral of the dorsal midline. After initial development of the milk lines they go into remission." xsd:string +[Term] +id: UBERON:0008429 +name: cervical vertebral foramen +is_a: UBERON:0001131 ! vertebral foramen +is_a: UBERON:0005744 ! bone foramen +intersection_of: UBERON:0001131 ! vertebral foramen +intersection_of: part_of UBERON:0002413 ! cervical vertebra +relationship: part_of UBERON:0002413 ! cervical vertebra + +[Term] +id: UBERON:0008430 +name: lumbar vertebral foramen +is_a: UBERON:0001131 ! vertebral foramen +is_a: UBERON:0005744 ! bone foramen +intersection_of: UBERON:0001131 ! vertebral foramen +intersection_of: part_of UBERON:0002414 ! lumbar vertebra +relationship: part_of UBERON:0002414 ! lumbar vertebra + +[Term] +id: UBERON:0008431 +name: sacral foramen +is_a: UBERON:0001131 ! vertebral foramen +is_a: UBERON:0005744 ! bone foramen +intersection_of: UBERON:0001131 ! vertebral foramen +intersection_of: part_of UBERON:0001094 ! sacral vertebra +relationship: part_of UBERON:0001094 ! sacral vertebra + +[Term] +id: UBERON:0008432 +name: thoracic vertebral foramen +is_a: UBERON:0001131 ! vertebral foramen +is_a: UBERON:0005744 ! bone foramen +intersection_of: UBERON:0001131 ! vertebral foramen +intersection_of: part_of UBERON:0002347 ! thoracic vertebra +relationship: part_of UBERON:0002347 ! thoracic vertebra + +[Term] +id: UBERON:0008433 +name: lumbar vertebral arch +is_a: UBERON:0003828 ! abdominal segment bone +is_a: UBERON:0003861 ! neural arch +is_a: UBERON:0004247 ! bone of dorsum +intersection_of: UBERON:0003861 ! neural arch +intersection_of: part_of UBERON:0002414 ! lumbar vertebra +relationship: part_of UBERON:0002414 ! lumbar vertebra + [Term] id: UBERON:0008434 name: cervical vertebral arch @@ -282458,8 +395974,40 @@ xref: SCTID:165269004 is_a: UBERON:0003458 ! neck bone is_a: UBERON:0003861 ! neural arch is_a: UBERON:0004247 ! bone of dorsum +intersection_of: UBERON:0003861 ! neural arch +intersection_of: part_of UBERON:0002413 ! cervical vertebra relationship: part_of UBERON:0002413 ! cervical vertebra +[Term] +id: UBERON:0008435 +name: vertebral arch of sacral segment +is_a: UBERON:0003828 ! abdominal segment bone +is_a: UBERON:0003861 ! neural arch +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0005179 ! pelvic region element +intersection_of: UBERON:0003861 ! neural arch +intersection_of: part_of UBERON:0001094 ! sacral vertebra +relationship: part_of UBERON:0001094 ! sacral vertebra + +[Term] +id: UBERON:0008436 +name: thoracic vertebral arch +is_a: UBERON:0003827 ! thoracic segment bone +is_a: UBERON:0003861 ! neural arch +is_a: UBERON:0004247 ! bone of dorsum +intersection_of: UBERON:0003861 ! neural arch +intersection_of: part_of UBERON:0002347 ! thoracic vertebra +relationship: part_of UBERON:0002347 ! thoracic vertebra + +[Term] +id: UBERON:0008447 +name: intertarsal joint +is_a: UBERON:0001487 ! pes joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001447 {cardinality="2"} ! tarsal bone +relationship: connects UBERON:0001447 ! tarsal bone +relationship: part_of UBERON:0004454 ! tarsal region + [Term] id: UBERON:0008488 name: cremaster muscle @@ -282499,6 +396047,8 @@ xref: SCTID:244730009 xref: UMLS:C0224219 {source="ncithesaurus:Nasal_Muscle"} is_a: UBERON:0001577 {source="FMA"} ! facial muscle is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: part_of UBERON:0000004 ! nose relationship: part_of UBERON:0000004 ! nose [Term] @@ -282513,7 +396063,7 @@ xref: FMA:46290 xref: SCTID:244824003 xref: Wikipedia:Suprahyoid_muscles is_a: UBERON:0005493 ! hyoid muscle -property_value: depicted:by Suprahyoid:muscles.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/5/58/Suprahyoid_muscles.png xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/697 xsd:anyURI [Term] @@ -282684,6 +396234,16 @@ xref: EMAPA:17748 xref: RETIRED_EHDAA2:0001422 is_a: UBERON:0001134 ! skeletal muscle tissue +[Term] +id: UBERON:0008715 +name: muscle tissue of prostate +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0002385 ! muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0002385 ! muscle tissue +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + [Term] id: UBERON:0008772 name: proximal epiphysis of tibia @@ -282701,6 +396261,8 @@ xref: UMLS:C0932431 {source="ncithesaurus:Head_of_the_Tibia"} xref: Wikipedia:Upper_extremity_of_tibia is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004383 ! epiphysis of tibia +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0000979 ! tibia [Term] id: UBERON:0008775 @@ -282722,6 +396284,8 @@ xref: UMLS:C0223908 {source="ncithesaurus:Head_of_the_Fibula"} xref: Wikipedia:Head_of_fibula is_a: UBERON:0004380 ! proximal epiphysis is_a: UBERON:0004388 ! epiphysis of fibula +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001446 ! fibula property_value: UBPROP:0000001 "The upper extremity or head of the fibula is of an irregular quadrate form, presenting above a flattened articular surface, directed upward, forward, and medialward, for articulation with a corresponding surface on the lateral condyle of the tibia. On the lateral side is a thick and rough prominence continued behind into a pointed eminence, the apex, which projects upward from the posterior part of the head. The prominence, at its upper and lateral part, gives attachment to the tendon of the Biceps femoris and to the fibular collateral ligament of the knee-joint, the ligament dividing the tendon into two parts. The remaining part of the circumference of the head is rough, for the attachment of muscles and ligaments. It presents in front a tubercle for the origin of the upper and anterior fibers of the Peronæus longus, and a surface for the attachment of the anterior ligament of the head; and behind, another tubercle, for the attachment of the posterior ligament of the head and the origin of the upper fibers of the Soleus[Wikipedia:Head_of_fibula]." xsd:string {source="Wikipedia:Head_of_fibula"} [Term] @@ -282807,9 +396371,16 @@ xref: NCIT:C34164 xref: UMLS:C1516906 {source="ncithesaurus:Epiblast"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002532 ! epiblast (generic) +intersection_of: UBERON:0002532 ! epiblast (generic) +intersection_of: develops_from UBERON:0000087 ! inner cell mass relationship: develops_from UBERON:0000087 {source="Wikipedia"} ! inner cell mass relationship: part_of UBERON:0000091 ! bilaminar disc +[Term] +id: UBERON:0008783 +name: dorsal venous arch +is_a: UBERON:0001638 ! vein + [Term] id: UBERON:0008784 name: lower limb segment @@ -282821,6 +396392,8 @@ synonym: "segment of free lower limb" EXACT [FMA:24877] synonym: "subdivision of free lower limb" EXACT [FMA:24877] xref: FMA:24877 is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: part_of UBERON:0002103 ! hindlimb relationship: part_of UBERON:0002103 ! hindlimb [Term] @@ -282834,6 +396407,8 @@ synonym: "segment of free upper limb" EXACT [FMA:24876] synonym: "subdivision of free upper limb" EXACT [FMA:24876] xref: FMA:24876 is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: part_of UBERON:0002102 ! forelimb relationship: part_of UBERON:0002102 ! forelimb [Term] @@ -282852,7 +396427,7 @@ xref: NCIT:C33361 xref: UMLS:C0010265 {source="ncithesaurus:Posterior_Fossa"} xref: Wikipedia:Posterior_cranial_fossa is_a: UBERON:0008789 ! cranial fossa -property_value: depicted:by Posterior:fossa.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/c/c2/Posterior_fossa.png xsd:anyURI [Term] id: UBERON:0008789 @@ -282861,6 +396436,8 @@ namespace: uberon def: "Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity." [http://mw1.merriam-webster.com/medical/cranial%20fossa] xref: FMA:321144 is_a: UBERON:0004704 ! bone fossa +intersection_of: UBERON:0004704 ! bone fossa +intersection_of: part_of UBERON:0003128 ! cranium relationship: part_of UBERON:0004766 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! cranial bone property_value: editor_note "todo - review the relationships for this and its subclasses; the relation should be bounded rather than part of, and contains should be used for the brain parts contained by the fossae" xsd:string @@ -282927,6 +396504,14 @@ xref: EHDAA2:0001413 xref: EHDAA:9246 is_a: UBERON:0001048 {source="Obol"} ! primordium +[Term] +id: UBERON:0008803 +name: skin of cheek +is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001567 ! cheek +relationship: part_of UBERON:0001567 ! cheek + [Term] id: UBERON:0008807 name: coagulating gland @@ -282957,6 +396542,17 @@ xref: EMAPA:35710 xref: MA:0001739 is_a: UBERON:0001328 {source="MA"} ! lobe of prostate +[Term] +id: UBERON:0008810 +name: nasopalatine nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: branching_part_of UBERON:0000377 ! maxillary nerve +intersection_of: innervates UBERON:0005046 ! mucosa of hard palate +relationship: branching_part_of UBERON:0000377 ! maxillary nerve +relationship: innervates UBERON:0005046 ! mucosa of hard palate + [Term] id: UBERON:0008811 name: intromittent organ @@ -282974,6 +396570,9 @@ xref: TAO:0002036 xref: TGMA:0000585 xref: Wikipedia:Intromittent_organ is_a: UBERON:0003135 ! male reproductive organ +relationship: capable_of_part_of GO:0007620 ! copulation +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: part_of UBERON:3011048 ! genital system property_value: IAO:0000232 "this is a broad grouping class connecting a number of different analagous organs by their function. We place the insect aedeagus here rather than penis, although this is somewhat arbitrary given the broadness of the current definition" xsd:string property_value: UBPROP:0000001 "Surface structure that is an external structure of a male organism through which sperm is transferred to a female organism during mating.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002036", ontology="TAO", source="TAO:wd"} @@ -283015,6 +396614,16 @@ intersection_of: UBERON:0000033 ! head intersection_of: part_of UBERON:0000922 ! embryo relationship: part_of UBERON:0000922 ! embryo +[Term] +id: UBERON:0008817 +name: thymus primordium endoderm +is_a: UBERON:0000925 ! endoderm +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000925 ! endoderm +intersection_of: part_of UBERON:0005562 ! thymus primordium +relationship: has_developmental_contribution_from UBERON:0007124 ! pharyngeal pouch 3 +relationship: part_of UBERON:0005562 ! thymus primordium + [Term] id: UBERON:0008823 name: neural tube derived brain @@ -283030,6 +396639,16 @@ relationship: part_of UBERON:0000033 {source="FMA"} ! head property_value: editor_note "a reasoner should automatically classify all the vertebrate ontology brain classes here" xsd:string property_value: seeAlso https://github.com/obophenotype/uberon/issues/338 xsd:anyURI +[Term] +id: UBERON:0008824 +name: duct of epididymis +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005904 ! duct of male reproductive system +intersection_of: UBERON:0000058 ! duct +intersection_of: branching_part_of UBERON:0001301 ! epididymis +relationship: branching_part_of UBERON:0001301 ! epididymis +relationship: part_of UBERON:0001301 ! epididymis + [Term] id: UBERON:0008826 name: pulmonary surfactant @@ -283042,10 +396661,15 @@ synonym: "type II pneumocyte secretion" EXACT [] xref: EMAPA:36551 xref: FMA:62780 xref: MA:0002534 +xref: MESH:D011663 xref: NCIT:C13273 xref: UMLS:C0034085 {source="ncithesaurus:Lung_Surfactant"} xref: Wikipedia:Pulmonary_surfactant is_a: UBERON:0006538 ! respiratory system fluid/secretion +intersection_of: UBERON:0006538 ! respiratory system fluid/secretion +intersection_of: produced_by CL:0002063 ! type II pneumocyte +relationship: has_part CHEBI:6495 ! lipoprotein +relationship: produced_by CL:0002063 ! type II pneumocyte property_value: UBPROP:0000009 "surfactant" xsd:string [Term] @@ -283114,6 +396738,7 @@ id: UBERON:0008833 name: great auricular nerve namespace: uberon def: "A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw." [http://medical-dictionary.thefreedictionary.com/great+auricular+nerve, Wikipedia:Great_auricular_nerve] +subset: human_reference_atlas synonym: "great auricular" RELATED [Wikipedia:Great_auricular_nerve] synonym: "greater auricular nerve" RELATED [Wikipedia:Great_auricular_nerve] synonym: "nervus auricularis magnus" EXACT LATIN [Wikipedia:Great_auricular_nerve] @@ -283122,6 +396747,7 @@ xref: SCTID:181110003 xref: Wikipedia:Great_auricular_nerve is_a: UBERON:0035648 ! nerve innervating pinna property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray805.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008834 @@ -283194,6 +396820,27 @@ is_a: UBERON:0012348 ! autopod pad relationship: part_of UBERON:0009877 ! metapodium region property_value: editor_note "check synonyms - re footpad" xsd:string +[Term] +id: UBERON:0008843 +name: gubernaculum testis +is_a: UBERON:0004346 ! gubernaculum (male or female) +intersection_of: UBERON:0004346 ! gubernaculum (male or female) +intersection_of: part_of UBERON:0000079 ! male reproductive system +relationship: attaches_to UBERON:0000473 ! testis +relationship: attaches_to UBERON:0001300 ! scrotum +relationship: attaches_to UBERON:0001301 ! epididymis +relationship: part_of UBERON:0000079 ! male reproductive system + +[Term] +id: UBERON:0008844 +name: gubernaculum (female) +is_a: UBERON:0004346 ! gubernaculum (male or female) +intersection_of: UBERON:0004346 ! gubernaculum (male or female) +intersection_of: part_of UBERON:0000474 ! female reproductive system +relationship: attaches_to UBERON:0000992 ! ovary +relationship: attaches_to UBERON:0000995 ! uterus +relationship: part_of UBERON:0000474 ! female reproductive system + [Term] id: UBERON:0008845 name: nonskeletal ligament @@ -283205,6 +396852,7 @@ xref: FMA:25625 xref: MA:0003004 xref: SCTID:410746001 is_a: UBERON:0000211 {source="cjm"} ! ligament +disjoint_from: UBERON:0008846 ! skeletal ligament property_value: UBPROP:0000001 "Ligament organ that primarily consists of dense connective tissue aggregated into fasciculi which may be admixed with smooth muscle. Examples: ligament of liver, ovarian ligament[FMA:25625]." xsd:string {source="FMA:25625"} property_value: UBPROP:0000012 "this class is used more generally than the FMA class, to include for example folds of mesentery such as the broad ligament of the uterus." xsd:string {external_ontology="FMA"} @@ -283228,9 +396876,17 @@ xref: MA:0003005 xref: SCTID:410744003 xref: VSAO:0000072 xref: Wikipedia:Ligament#Articular_ligaments +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000211 ! ligament +intersection_of: UBERON:0000211 ! ligament +intersection_of: connects UBERON:0004765 ! skeletal element +intersection_of: part_of UBERON:0001434 ! skeletal system +relationship: composed_primarily_of UBERON:0007846 {source="VSAO"} ! dense regular connective tissue +relationship: connects UBERON:0004765 {notes="bones or cartilage organs"} ! skeletal element +relationship: has_part CL:0000057 {source="AEO"} ! fibroblast +relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell relationship: part_of UBERON:0001434 ! skeletal system -property_value: depicted:by Knee:diagram.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg xsd:anyURI property_value: editor_note "logical definition deliberately made strict to avoid classifying MA:spiral ligament as both nonskeletal and skeletal. see https://github.com/obophenotype/mouse-anatomy-ontology/issues/71" xsd:string property_value: UBPROP:0000001 "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000072", ontology="VSAO", source="PSPUB:0000170"} property_value: UBPROP:0000001 "Ligament organ that primarily consists of regular dense connective tissue aggregated into fasciculi; connects bone and cartilage organs. Examples: sutural ligament, ligament of pinna, tarsal ligament[FMA:25624]." xsd:string {source="FMA:25624"} @@ -283314,6 +396970,10 @@ xref: SCTID:362132003 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0018261 ! muscular coat of digestive tract is_a: UBERON:0034933 ! layer of smooth muscle tissue +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0001167 ! wall of stomach +relationship: contributes_to_morphology_of UBERON:0001135 ! smooth muscle tissue +relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach relationship: part_of UBERON:0004222 {source="MA-abduced"} ! stomach smooth muscle property_value: UBPROP:0000010 "the muscularis externa in the stomach differs from that of other GI organs in that it has three layers of smooth muscle instead of two" xsd:string {source="WP"} @@ -283351,8 +397011,11 @@ xref: FMA:14580 xref: SCTID:245417002 xref: Wikipedia:Pyloric_canal is_a: UBERON:0009870 {source="FMA"} ! zone of stomach +relationship: continuous_with UBERON:0001165 ! pyloric antrum +relationship: continuous_with UBERON:0001202 ! pyloric sphincter +relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus relationship: part_of UBERON:0001166 {source="Wikipedia"} ! pylorus -property_value: depicted:by Illu:stomach.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg xsd:anyURI [Term] id: UBERON:0008859 @@ -283373,6 +397036,9 @@ xref: SCTID:8894005 xref: Wikipedia:Cardiac_glands is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 {source="MP"} ! mucous gland +intersection_of: UBERON:0000325 ! gastric gland +intersection_of: part_of UBERON:0001162 ! cardia of stomach +relationship: contributes_to_morphology_of UBERON:0001162 ! cardia of stomach relationship: part_of UBERON:0004996 {source="FMA"} ! mucosa of cardia of stomach property_value: UBPROP:0000001 "The cardiac glands of the stomach secrete primarily mucus. They are few in number and occur close to the cardiac orifice where the esophagus joins the stomach. In general, they are more shallow than those in the other parts of the stomach. They are of two kinds: (1) simple tubular glands resembling those of the pyloric end of the stomach, but with short ducts. (2) compound racemose glands resembling the duodenal glands. The cardiac gland is both innervated by the parasympathetic and symapthetic nerve fibres of the autonomic nervous system[Wikipedia:Cardiac_glands]." xsd:string {source="Wikipedia:Cardiac_glands"} property_value: UBPROP:0000012 "Kardong places this in the glandular epithelium, FMA more generally in the mucosa" xsd:string {external_ontology="FMA"} @@ -283404,6 +397070,10 @@ xref: UMLS:C0227239 {source="ncithesaurus:Pyloric_Gland"} xref: Wikipedia:Pyloric_gland is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 {source="MP"} ! mucous gland +intersection_of: UBERON:0000325 ! gastric gland +intersection_of: part_of UBERON:0001166 ! pylorus +relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus +relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular relationship: part_of UBERON:0004998 ! mucosa of pylorus property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png xsd:anyURI property_value: editor_note "check relationship to pylorus vs antrum" xsd:string @@ -283475,10 +397145,15 @@ id: UBERON:0008870 name: pulmonary alveolar parenchyma namespace: uberon def: "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." [MP:0010901] +subset: human_reference_atlas subset: pheno_slim xref: EMAPA:37942 {source="MA:th"} is_a: UBERON:0008946 ! lung parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0002299 ! alveolus of lung +relationship: contributes_to_morphology_of UBERON:0006524 ! alveolar system relationship: part_of UBERON:0002299 ! alveolus of lung +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008873 @@ -283496,6 +397171,7 @@ id: UBERON:0008874 name: pulmonary acinus namespace: uberon def: "The part of the airway consisting of a respiratory bronchiole and all of its branches." [MP:0010911, Wikipedia:Acinus#The_Lungs] +subset: human_reference_atlas subset: pheno_slim synonym: "acinus pulmonaris" EXACT LATIN [FMA:7313, FMA:TA] synonym: "arbor alveolaris" EXACT LATIN [FMA:7313, FMA:TA] @@ -283509,6 +397185,7 @@ xref: SCTID:361365004 xref: UMLS:C0225696 {source="ncithesaurus:Pulmonary_Acinus"} xref: Wikipedia:Acinus#The_Lungs is_a: UBERON:0010368 {source="FMA"} ! pulmonary lobule +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008876 @@ -283523,6 +397200,7 @@ synonym: "panniculus carnosus" NARROW [MP:0011157] synonym: "superficial fascia muscular layer" EXACT [] xref: EMAPA:18188 xref: MA:0003140 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004253 ! skin muscle is_a: UBERON:0014892 ! skeletal muscle organ @@ -283599,6 +397277,9 @@ subset: pheno_slim xref: EMAPA:37955 {source="MA:th"} is_a: UBERON:0001020 ! nervous system commissure is_a: UBERON:0007699 ! tract of spinal cord +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: part_of UBERON:0002240 ! spinal cord +relationship: contributes_to_morphology_of UBERON:0002240 ! spinal cord [Term] id: UBERON:0008883 @@ -283620,7 +397301,7 @@ xref: VSAO:0000046 xref: Wikipedia:Osteoid xref: XAO:0004035 is_a: UBERON:0002481 {source="VSAO"} ! bone tissue -property_value: depicted:by Active:osteoblasts.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg xsd:anyURI property_value: UBPROP:0000001 "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000046", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"} property_value: UBPROP:0000001 "Newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalci[ISBN:0-683-40008-8]n" xsd:string {reference="ISBN:0-683-40008-8", source="MP:0010924"} property_value: UBPROP:0000012 "Note that in VSAO this was classified both as tissue and acellular extracellular matrix. Consider also the AEO class 'bone condensation'. is_a intercellular matrix in FMA." xsd:string {external_ontology="VSAO"} @@ -283630,6 +397311,7 @@ id: UBERON:0008886 name: pulmonary vascular system namespace: uberon def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." [ISBN:0073040584, Wikipedia:Pulmonary_circulation] +subset: human_reference_atlas synonym: "pulmonary circulatory system" EXACT [FMA:45621] synonym: "pulmonary system" EXACT [ISBN:0073040584] xref: FMA:45621 @@ -283638,8 +397320,17 @@ is_a: UBERON:0007798 {source="Obol"} ! vascular system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: has_part UBERON:0002012 ! pulmonary artery relationship: has_part UBERON:0002016 ! pulmonary vein +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA]" xsd:string {ontology="FMA", source="FMA:45621"} +[Term] +id: UBERON:0008887 +name: rectal venous plexus +is_a: UBERON:0001593 ! venous plexus +intersection_of: UBERON:0001593 ! venous plexus +intersection_of: surrounds UBERON:0001052 ! rectum +relationship: surrounds UBERON:0001052 ! rectum + [Term] id: UBERON:0008895 name: splanchnocranium @@ -283796,9 +397487,9 @@ xref: BTO:0004353 xref: EFO:0001391 xref: FMA:242642 xref: GAID:681 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3241 xref: MBA:453 -xref: MESH:A08.186.211.730.885.213.670.675 +xref: MESH:D013003 +xref: neuronames:3241 xref: SCTID:279252006 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0035014 {source="NIFSTD"} ! functional part of brain @@ -283822,9 +397513,9 @@ xref: BAMS:S1 xref: BAMS:SSp xref: DHBA:10209 xref: EMAPA:35706 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1350 xref: MA:0000908 xref: MBA:322 +xref: neuronames:1350 xref: NLX:143551 is_a: UBERON:0008930 ! somatosensory cortex relationship: part_of UBERON:0016530 {source="DHBA", source="MA", source="NIFSTD"} ! parietal cortex @@ -283842,9 +397533,9 @@ synonym: "supplemental somatosensory area" RELATED [BAMS:SSs] xref: BAMS:S2 xref: BAMS:SSs xref: EMAPA:35756 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1909 xref: MA:0000918 xref: MBA:378 +xref: neuronames:1909 is_a: UBERON:0008930 ! somatosensory cortex relationship: part_of UBERON:0010262 {source="WP"} ! operculum of brain property_value: editor_note "TODO - check brodmann" xsd:string @@ -283937,6 +397628,14 @@ xref: UMLS:C0225758 {source="ncithesaurus:Lung_Lower_Lobe"} is_a: UBERON:0000101 ! lobe of lung property_value: editor_note "defining lobes spatially across species" xsd:string +[Term] +id: UBERON:0008951 +name: left lung lobe +is_a: UBERON:0000101 ! lobe of lung +intersection_of: UBERON:0000101 ! lobe of lung +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0002168 ! left lung + [Term] id: UBERON:0008955 name: middle lobe of lung @@ -283997,6 +397696,7 @@ xref: Wikipedia:Dental_follicle is_a: UBERON:0007499 ! epithelial sac is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010371 ! ecto-epithelium +relationship: has_part CL:0007002 ! precementoblast relationship: part_of UBERON:0008281 ! tooth bud [Term] @@ -284004,15 +397704,18 @@ id: UBERON:0008974 name: apocrine gland namespace: uberon def: "Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk." [MGI:anna] +subset: human_reference_atlas subset: organ_slim subset: pheno_slim synonym: "true apocrine gland" EXACT [] xref: BTO:0001162 xref: EMAPA:35141 xref: MA:0003040 +xref: MESH:D001050 xref: SCTID:361698000 xref: Wikipedia:Apocrine is_a: UBERON:0002365 ! exocrine gland +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000007 "apocrine" xsd:string property_value: UBPROP:0000008 "Mammary glands are modified apocrine glands present in both humans and mice; unlike humans, mice do not have axillary apocrine sweat glands[MGI:anna]" xsd:string @@ -284032,6 +397735,8 @@ xref: SCTID:181772008 xref: UMLS:C0015641 {source="ncithesaurus:Fascia"} xref: Wikipedia:Fascia is_a: UBERON:0007846 {source="Wikipedia"} ! dense regular connective tissue +relationship: connects UBERON:0001630 {cardinality="2"} ! muscle organ +relationship: connects UBERON:0001630 ! muscle organ relationship: part_of UBERON:0002204 ! musculoskeletal system [Term] @@ -284046,8 +397751,34 @@ xref: FMA:15574 xref: SCTID:29704000 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000353 {source="FMA"} ! parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 {source="FMA"} ! kidney +[Term] +id: UBERON:0008989 +name: submucosal esophageal gland +namespace: uberon +def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." [BTO:0003634, Wikipedia:Esophageal_glands] +synonym: "esophageal gland" EXACT [FMA:9404] +synonym: "glandulae oesophageae" EXACT [Wikipedia:Esophageal_glands] +synonym: "mucous gland of submucosa of esophagus" EXACT [FMA:9404] +synonym: "submocosal esophageal gland" RELATED [] +xref: BTO:0003634 +xref: FMA:9404 +xref: NCIT:C32536 +xref: SCTID:322749003 +xref: UMLS:C0227178 {source="ncithesaurus:Esophageal_Gland"} +xref: Wikipedia:Esophageal_glands +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0005178 ! thoracic cavity element +is_a: UBERON:0011148 ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: part_of UBERON:0001043 ! esophagus +relationship: located_in UBERON:0001972 ! submucosa of esophagus +relationship: part_of UBERON:0001043 ! esophagus +property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg xsd:anyURI + [Term] id: UBERON:0008995 name: nucleus of cerebellar nuclear complex @@ -284124,6 +397855,15 @@ intersection_of: surrounds UBERON:0000057 ! urethra relationship: part_of UBERON:0001556 ! lower urinary tract relationship: surrounds UBERON:0000057 ! urethra +[Term] +id: UBERON:0009014 +name: lower back skin +is_a: UBERON:0001068 ! skin of back +is_a: UBERON:0003836 ! abdominal segment skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0005462 ! lower back +relationship: part_of UBERON:0005462 ! lower back + [Term] id: UBERON:0009015 name: upper back skin @@ -284138,6 +397878,22 @@ intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0008231 ! dorsal thoracic segment of trunk relationship: part_of UBERON:0008231 ! dorsal thoracic segment of trunk +[Term] +id: UBERON:0009020 +name: left uterine horn +is_a: UBERON:0002247 ! uterine horn +intersection_of: UBERON:0002247 ! uterine horn +intersection_of: in_left_side_of UBERON:0000995 ! uterus +relationship: in_left_side_of UBERON:0000995 ! uterus + +[Term] +id: UBERON:0009022 +name: right uterine horn +is_a: UBERON:0002247 ! uterine horn +intersection_of: UBERON:0002247 ! uterine horn +intersection_of: in_right_side_of UBERON:0000995 ! uterus +relationship: in_right_side_of UBERON:0000995 ! uterus + [Term] id: UBERON:0009024 name: adrenal gland X zone @@ -284151,6 +397907,14 @@ xref: MA:0001888 xref: SCTID:24306004 is_a: UBERON:0009753 {source="MA"} ! adrenal gland cortex zone +[Term] +id: UBERON:0009027 +name: vesical artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001255 ! urinary bladder +relationship: supplies UBERON:0001255 ! urinary bladder + [Term] id: UBERON:0009030 name: left pulmonary vein @@ -284216,6 +397980,7 @@ id: UBERON:0009039 name: lymph node germinal center namespace: uberon def: "A germinal center that is located in a lymph node." [CL:tm] +subset: human_reference_atlas subset: pheno_slim synonym: "germinal center" BROAD [BTO:0003671] synonym: "lymph node activated zone" RELATED [] @@ -284230,6 +397995,67 @@ xref: NCIT:C49757 xref: SCTID:327147000 is_a: UBERON:0010754 ! germinal center relationship: part_of UBERON:0010753 {source="MA"} ! lymph node secondary follicle +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0009042 +name: prostatic venous plexus +is_a: UBERON:0001593 ! venous plexus +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0001593 ! venous plexus +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0009097 +name: gravid organism +namespace: uberon +def: "An organism containing a developing embryo, fetus, or unborn offspring within the body." [BTO:0004733] +synonym: "gravid" RELATED [BTO:0004733] +synonym: "pregnant adult" RELATED [BTO:0004733] +synonym: "pregnant adult stage" RELATED [BTO:0004733] +synonym: "pregnant organism" RELATED [] +synonym: "pregnant stage" RELATED [BTO:0004733] +xref: BTO:0004733 +is_a: UBERON:0007023 ! adult organism +intersection_of: UBERON:0007023 ! adult organism +intersection_of: has_part UBERON:0000922 ! embryo +relationship: has_part UBERON:0000922 ! embryo +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa +relationship: participates_in GO:0007565 ! female pregnancy + +[Term] +id: UBERON:0009098 +name: gravid uterus +namespace: uberon +def: "The uterus in pregnancy." [http://medical-dictionary.thefreedictionary.com/gravid+uterus] +synonym: "womb" RELATED [] +xref: NCIT:C12406 +xref: ncithesaurus:Gravid_Uterus +xref: SCTID:362253003 +xref: UMLS:C1514389 {source="ncithesaurus:Pregnant_Uterus"} +is_a: UBERON:0000995 ! uterus +intersection_of: UBERON:0000995 ! uterus +intersection_of: location_of UBERON:0000922 ! embryo +relationship: contains_process GO:0007565 ! female pregnancy +relationship: location_of UBERON:0000922 ! embryo +relationship: part_of UBERON:0009097 ! gravid organism + +[Term] +id: UBERON:0009114 +name: cervical thymus +is_a: UBERON:0002370 ! thymus +intersection_of: UBERON:0002370 ! thymus +intersection_of: part_of UBERON:0000974 ! neck +relationship: part_of UBERON:0000974 ! neck + +[Term] +id: UBERON:0009115 +name: thoracic thymus +is_a: UBERON:0002370 ! thymus +is_a: UBERON:0005178 ! thoracic cavity element +intersection_of: UBERON:0002370 ! thymus +intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0009117 @@ -284344,7 +398170,6 @@ xref: VHOG:0001228 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002166 ! endocardium of atrium is_a: UBERON:0005291 ! embryonic tissue -is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0002165 ! endocardium intersection_of: part_of UBERON:0002078 ! right cardiac atrium @@ -284370,7 +398195,10 @@ xref: EHDAA:8297 xref: EMAPA:36251 xref: SCTID:181694005 xref: Wikipedia:Fibularis_muscles +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004256 ! hindlimb zeugopod muscle +relationship: has_muscle_insertion UBERON:0001448 ! metatarsal bone +relationship: has_muscle_origin UBERON:0001446 ! fibula [Term] id: UBERON:0009133 @@ -284449,6 +398277,9 @@ is_a: UBERON:0005866 {source="EHDAA2"} ! pre-cartilage condensation is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: part_of UBERON:0001703 {source="EHDAA2"} ! neurocranium relationship: part_of UBERON:0002241 {source="EHDAA2"} ! chondrocranium @@ -284478,6 +398309,8 @@ is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0009191 ! sphenoid bone pre-cartilage condensation [Term] @@ -284570,6 +398403,32 @@ is_a: UBERON:0034969 ! epithelial layer of duct union_of: UBERON:0003060 ! pronephric duct union_of: UBERON:0003074 ! mesonephric duct +[Term] +id: UBERON:0009204 +name: medial nasal process mesenchyme +is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0004068 ! medial nasal prominence +relationship: part_of UBERON:0004068 ! medial nasal prominence + +[Term] +id: UBERON:0009205 +name: lateral nasal process mesenchyme +is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0004067 ! lateral nasal prominence +relationship: part_of UBERON:0004067 ! lateral nasal prominence + +[Term] +id: UBERON:0009206 +name: lateral nasal process surface ectoderm +is_a: UBERON:0000924 ! ectoderm +is_a: UBERON:0014702 ! frontonasal process epithelium +intersection_of: UBERON:0000924 ! ectoderm +intersection_of: part_of UBERON:0004067 ! lateral nasal prominence +relationship: part_of UBERON:0000076 ! external ectoderm +relationship: part_of UBERON:0004067 ! lateral nasal prominence + [Term] id: UBERON:0009210 name: pharyngeal membrane @@ -284586,6 +398445,10 @@ xref: NCIT:C34251 xref: UMLS:C1519040 {source="ncithesaurus:Pharyngeal_Membrane"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002050 ! embryonic structure +relationship: has_part UBERON:0000924 ! ectoderm +relationship: has_part UBERON:0000925 ! endoderm +relationship: overlaps UBERON:0004117 ! pharyngeal pouch +relationship: overlaps UBERON:0005879 ! pharyngeal cleft relationship: part_of UBERON:0002539 {source="EMAPA"} ! pharyngeal arch property_value: UBPROP:0000003 "In all vertebrates, the endodermal epithelium lining each pouch contacts the surface ectoderm of the clefts to form a series of bilayered branchial membranes, that break down in fish to form the gill openings.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001427", ontology="VHOG", source="ISBN:978-0124020603 Kaufman MH, Bard JBL, The anatomical basis of mouse development (1999) p.72", source="http://bgee.unil.ch/"} @@ -284604,9 +398467,20 @@ xref: EMAPA:16992 xref: EMAPA:17281 xref: VHOG:0001427 is_a: UBERON:0009210 ! pharyngeal membrane +relationship: overlaps UBERON:0005872 ! 1st arch pharyngeal cleft +relationship: overlaps UBERON:0007122 ! pharyngeal pouch 1 relationship: part_of UBERON:0004362 {source="EMAPA"} ! pharyngeal arch 1 property_value: editor_note "check EMAPA - 3 terms appear to match. We follow EMAPA in making each membrane part of the arch with the same number, though in fact it is between these arches" xsd:string +[Term] +id: UBERON:0009291 +name: cartilaginous vertebral centrum +is_a: UBERON:0007844 ! cartilage element +is_a: UBERON:0016491 ! vertebral centrum element +intersection_of: UBERON:0016491 ! vertebral centrum element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +relationship: part_of UBERON:0011094 ! vertebra cartilage element + [Term] id: UBERON:0009292 name: embryonic nasal process @@ -284679,6 +398553,15 @@ xref: Wikipedia:Parapodium is_a: UBERON:0000026 {source="cjm"} ! appendage relationship: part_of UBERON:0000914 ! organismal segment +[Term] +id: UBERON:0009477 +name: associated mesenchyme of otic placode +is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003069 ! otic placode +relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest +relationship: part_of UBERON:0003069 ! otic placode + [Term] id: UBERON:0009479 name: ectoderm of buccopharyngeal membrane @@ -284719,6 +398602,22 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction +[Term] +id: UBERON:0009483 +name: mesentery of foregut-midgut junction +namespace: uberon +def: "A mesentery that is part of a foregut-midgut junction." [OBOL:automatic] +subset: emapa_ehdaa2 +synonym: "foregut-midgut junction mesentery" EXACT [VHOG:0000430] +xref: EHDAA2:0000575 +xref: EMAPA:16365 +xref: VHOG:0000430 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0006235 ! foregut-midgut junction +relationship: part_of UBERON:0006235 ! foregut-midgut junction +property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000430", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"} + [Term] id: UBERON:0009494 name: pharyngeal arch mesenchymal region @@ -284755,6 +398654,16 @@ intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: develops_from UBERON:0009550 {source="EHDAA2"} ! endoderm of foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction +[Term] +id: UBERON:0009500 +name: periotic mesenchyme +is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: surrounds UBERON:0003051 ! ear vesicle +relationship: develops_from UBERON:0009477 ! associated mesenchyme of otic placode +relationship: part_of UBERON:0001444 ! subdivision of head +relationship: surrounds UBERON:0003051 ! ear vesicle + [Term] id: UBERON:0009501 name: mesenchyme of fronto-nasal process @@ -284768,6 +398677,8 @@ xref: EHDAA2:0004109 xref: EMAPA:16683 xref: FMA:295821 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0004066 ! frontonasal prominence relationship: develops_from UBERON:0007213 ! mesenchyme derived from head neural crest relationship: part_of UBERON:0004066 ! frontonasal prominence @@ -284786,6 +398697,15 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0001046 ! hindgut relationship: part_of UBERON:0001046 ! hindgut +[Term] +id: UBERON:0009504 +name: mesenchyme of main bronchus +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + [Term] id: UBERON:0009505 name: mesenchyme of trachea @@ -284798,9 +398718,23 @@ xref: EMAPA:16854 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from UBERON:0002539 ! pharyngeal arch relationship: part_of UBERON:0003126 ! trachea +[Term] +id: UBERON:0009506 +name: mesenchyme of middle ear +is_a: UBERON:0005253 ! head mesenchyme +is_a: UBERON:0007524 ! dense mesenchyme tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001756 ! middle ear +relationship: has_developmental_contribution_from UBERON:0005689 ! 2nd arch mesenchyme +relationship: has_developmental_contribution_from UBERON:0010045 ! 1st arch maxillary mesenchyme +relationship: part_of UBERON:0001756 ! middle ear + [Term] id: UBERON:0009521 name: anal membrane endodermal component @@ -284845,6 +398779,8 @@ xref: EHDAA2:0000731 xref: EMAPA:17248 xref: EMAPA:17457 is_a: UBERON:0010377 ! mesenchyme from somatopleure +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0006875 ! embryonic handplate relationship: develops_from UBERON:0003413 {source="EHDAA2"} ! pectoral appendage bud mesenchyme relationship: part_of UBERON:0006875 ! embryonic handplate property_value: UBPROP:0000012 "We group two EMAPA classes here but these may need to be separated" xsd:string {external_ontology="EMAPA"} @@ -284863,8 +398799,80 @@ xref: FMA:312691 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0005868 ! maxillary prominence relationship: part_of UBERON:0005868 ! maxillary prominence +[Term] +id: UBERON:0009536 +name: vascular element of left lung +is_a: UBERON:0000102 ! lung vasculature +is_a: UBERON:0005629 ! vascular plexus +intersection_of: UBERON:0005629 ! vascular plexus +intersection_of: part_of UBERON:0002168 ! left lung +relationship: part_of UBERON:0002168 ! left lung + +[Term] +id: UBERON:0009537 +name: vascular element of right lung +is_a: UBERON:0000102 ! lung vasculature +is_a: UBERON:0005629 ! vascular plexus +intersection_of: UBERON:0005629 ! vascular plexus +intersection_of: part_of UBERON:0002167 ! right lung +relationship: part_of UBERON:0002167 ! right lung + +[Term] +id: UBERON:0009538 +name: mesenchyme of sublingual gland primordium +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0006297 ! sublingual gland primordium +relationship: develops_from UBERON:0003324 ! mesenchyme of lower jaw +relationship: part_of UBERON:0006297 ! sublingual gland primordium + +[Term] +id: UBERON:0009539 +name: mesenchyme of submandibular gland primordium +is_a: UBERON:0003324 ! mesenchyme of lower jaw +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0006298 ! submandibular gland primordium +relationship: develops_from UBERON:0003324 ! mesenchyme of lower jaw +relationship: part_of UBERON:0006298 ! submandibular gland primordium + +[Term] +id: UBERON:0009548 +name: hepatic sinusoid of left of lobe of liver +namespace: uberon +def: "A hepatic sinusoid that is part of a left lobe of liver." [OBOL:automatic] +subset: emapa_ehdaa2 +synonym: "left lobe hepatic sinusoids" EXACT [VHOG:0000709] +xref: EHDAA2:0001001 +xref: EMAPA:18309 +xref: VHOG:0000709 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: part_of UBERON:0001115 ! left lobe of liver +relationship: develops_in UBERON:0001115 ! left lobe of liver +relationship: part_of UBERON:0001115 ! left lobe of liver + +[Term] +id: UBERON:0009549 +name: hepatic sinusoid of right of lobe of liver +namespace: uberon +def: "A hepatic sinusoid that is part of a right lobe of liver." [OBOL:automatic] +subset: emapa_ehdaa2 +synonym: "right lobe hepatic sinusoids" EXACT [VHOG:0000710] +xref: EHDAA2:0001009 +xref: EMAPA:18316 +xref: VHOG:0000710 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: part_of UBERON:0001114 ! right lobe of liver +relationship: develops_in UBERON:0001114 ! right lobe of liver +relationship: part_of UBERON:0001114 ! right lobe of liver + [Term] id: UBERON:0009550 name: endoderm of foregut-midgut junction @@ -284887,6 +398895,8 @@ synonym: "digit tip" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "distal digit segment" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tip of digit" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002529 ! limb segment +relationship: has_part UBERON:0004300 ! distal phalanx +relationship: overlaps UBERON:0009768 ! distal interphalangeal joint relationship: part_of UBERON:0002544 ! digit property_value: UBPROP:0000011 "Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit tips after their amputation through the distal interphalangeal joint. Regeneration of the digit tip involves the integrated regrowth of multiple tissues within 2-3 months, reaching an external morphology that is cosmetically and functionally similar to normal digits. Most importantly, regeneration of the mouse distal digit shares morphological similarities with clinical cases documenting regrowth of missing distal portions of fingers in both children and adults" xsd:string @@ -284907,6 +398917,8 @@ xref: OpenCyc:Mx4rvVjpf5wpEbGdrcN5Y29ycA xref: SCTID:312543003 is_a: UBERON:0005451 ! segment of manus is_a: UBERON:0009551 ! distal segment of digit +intersection_of: UBERON:0009551 ! distal segment of digit +intersection_of: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0002389 ! manual digit [Term] @@ -284922,8 +398934,22 @@ synonym: "toe digit tip" EXACT [DOI:10.1038/nature10346] synonym: "toe distal segment" EXACT [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005445 ! segment of pes is_a: UBERON:0009551 ! distal segment of digit +intersection_of: UBERON:0009551 ! distal segment of digit +intersection_of: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0001466 ! pedal digit +[Term] +id: UBERON:0009559 +name: metacarpal/tarsal-phalangeal joint +is_a: UBERON:0003841 ! autopod joint +is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0003656 ! mesopodium bone +intersection_of: connects UBERON:0004302 ! proximal phalanx +relationship: connects UBERON:0003656 ! mesopodium bone +relationship: connects UBERON:0004302 ! proximal phalanx +relationship: part_of UBERON:0002544 ! digit + [Term] id: UBERON:0009564 name: distal limb integumentary appendage @@ -284961,6 +398987,8 @@ xref: NCIT:C32609 xref: SCTID:244197001 xref: UMLS:C0222001 {source="ncithesaurus:Fingernail"} is_a: UBERON:0001705 ! nail +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0005276 {source="FMA"} ! dorsal skin of finger relationship: part_of UBERON:0009552 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! distal segment of manual digit @@ -285000,6 +399028,8 @@ xref: SCTID:244198006 xref: UMLS:C0222007 {source="ncithesaurus:Toe_Nail"} xref: XAO:0003103 is_a: UBERON:0001705 ! nail +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0005277 {source="FMA"} ! dorsal skin of toe relationship: part_of UBERON:0009553 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! distal segment of pedal digit @@ -285025,7 +399055,11 @@ xref: FMA:72066 xref: NCIT:C92597 xref: SCTID:281699004 is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: part_of UBERON:0002100 ! trunk +intersection_of: subdivision_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk +relationship: subdivision_of UBERON:0002100 ! trunk property_value: UBPROP:0000001 "Region of the vertebral column between the atlas and the sacrum consisting of seven to 285 vertebrae.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000612", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"} [Term] @@ -285055,6 +399089,19 @@ intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: part_of UBERON:0006241 ! future spinal cord relationship: part_of UBERON:0006241 ! future spinal cord +[Term] +id: UBERON:0009572 +name: lumen of central canal of spinal cord +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0002291 ! central canal of spinal cord +relationship: luminal_space_of UBERON:0002291 ! central canal of spinal cord +relationship: part_of UBERON:0002291 ! central canal of spinal cord +relationship: surrounds UBERON:0001359 ! cerebrospinal fluid +relationship: transformation_of UBERON:0003842 ! neural tube lumen + [Term] id: UBERON:0009576 name: medulla oblongata sulcus limitans @@ -285293,6 +399340,23 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005256 ! trunk mesenchyme relationship: part_of UBERON:0003077 ! paraxial mesoderm +[Term] +id: UBERON:0009621 +name: tail somite +is_a: UBERON:0002329 ! somite +intersection_of: UBERON:0002329 ! somite +intersection_of: part_of UBERON:0002415 ! tail +relationship: part_of UBERON:0002415 ! tail + +[Term] +id: UBERON:0009622 +name: pronephric proximal straight tubule +is_a: UBERON:0001290 ! proximal straight tubule +is_a: UBERON:0005310 ! pronephric nephron tubule +intersection_of: UBERON:0001290 ! proximal straight tubule +intersection_of: part_of UBERON:0002120 ! pronephros +relationship: part_of UBERON:0006173 ! pronephric proximal tubule + [Term] id: UBERON:0009623 name: spinal nerve root @@ -285313,6 +399377,22 @@ xref: ZFA:0005578 is_a: UBERON:0002211 {source="FMA"} ! nerve root property_value: UBPROP:0000012 "ZFA has part_of to spinal cord but this causes spatial disjointness violations (CNS/PNS)" xsd:string {external_ontology="ZFA"} +[Term] +id: UBERON:0009624 +name: lumbar nerve +is_a: UBERON:0001780 ! spinal nerve +intersection_of: UBERON:0001780 ! spinal nerve +intersection_of: extends_fibers_into UBERON:0002792 ! lumbar spinal cord +relationship: extends_fibers_into UBERON:0002792 ! lumbar spinal cord + +[Term] +id: UBERON:0009625 +name: sacral nerve +is_a: UBERON:0001780 ! spinal nerve +intersection_of: UBERON:0001780 ! spinal nerve +intersection_of: extends_fibers_into UBERON:0005843 ! sacral spinal cord +relationship: extends_fibers_into UBERON:0005843 ! sacral spinal cord + [Term] id: UBERON:0009635 name: parachordal cartilage @@ -285380,6 +399460,14 @@ def: "Forms around the developing pituitary, and together with prechordal cartil comment: classified as part of chondrocranium based on developmental relationships is_a: UBERON:0003932 ! cartilage element of chondrocranium +[Term] +id: UBERON:0009644 +name: trachea non-cartilage connective tissue +namespace: uberon +xref: EMAPA:35878 +xref: MA:0001859 +is_a: UBERON:0003571 {source="MA"} ! trachea connective tissue + [Term] id: UBERON:0009645 name: ampullary gland @@ -285400,11 +399488,74 @@ property_value: UBPROP:0000008 "Ampullary glands are situated in an ampulla-like property_value: UBPROP:0000008 "there is no known human counterpart to the ampullary glands of the mouse[MP]" xsd:string property_value: UBPROP:0000010 "usually encapsulated by connective tissue and containing smooth muscle" xsd:string +[Term] +id: UBERON:0009647 +name: tympanic membrane epithelium +is_a: UBERON:0010071 ! layer of tympanic membrane +is_a: UBERON:0015813 ! middle ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002364 ! tympanic membrane +disjoint_from: UBERON:0010070 ! intermediate layer of tympanic membrane + +[Term] +id: UBERON:0009648 +name: eyelid subcutaneous connective tissue +is_a: UBERON:0003581 ! eyelid connective tissue +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0003581 ! eyelid connective tissue +intersection_of: part_of UBERON:0002072 ! hypodermis +relationship: adjacent_to UBERON:0001457 ! skin of eyelid +relationship: part_of UBERON:0002072 ! hypodermis + +[Term] +id: UBERON:0009651 +name: nephron tubule basement membrane +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005769 ! basement membrane of epithelium +intersection_of: UBERON:0005769 ! basement membrane of epithelium +intersection_of: part_of UBERON:0001231 ! nephron tubule +relationship: part_of UBERON:0004810 ! nephron tubule epithelium + +[Term] +id: UBERON:0009652 +name: bronchus basement membrane +namespace: uberon +def: "A basement membrane that is part of a bronchus." [OBOL:automatic] +synonym: "bronchial basement membrane" EXACT [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:37809 {source="MA:th"} +xref: MA:0001832 +xref: NCIT:C49208 +xref: UMLS:C1707051 {source="ncithesaurus:Bronchus_Basement_Membrane"} +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0015329 ! respiratory system basement membrane +intersection_of: UBERON:0005769 ! basement membrane of epithelium +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002031 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! epithelium of bronchus +property_value: UBPROP:0000012 "MA classifies as type of connective tissue: https://github.com/obophenotype/mouse-anatomy-ontology/issues/108" xsd:string {external_ontology="MA"} + +[Term] +id: UBERON:0009653 +name: trachea basement membrane +namespace: uberon +def: "A basement membrane that is part of a trachea." [OBOL:automatic] +xref: EMAPA:37552 {source="MA:th"} +xref: MA:0001854 +xref: NCIT:C49302 +xref: UMLS:C1710455 {source="ncithesaurus:Trachea_Basement_Membrane"} +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0015329 ! respiratory system basement membrane +intersection_of: UBERON:0005769 ! basement membrane of epithelium +intersection_of: part_of UBERON:0003126 ! trachea +relationship: part_of UBERON:0001901 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! epithelium of trachea +relationship: part_of UBERON:0009644 {source="MA-modified"} ! trachea non-cartilage connective tissue + [Term] id: UBERON:0009654 name: alveolar artery namespace: uberon def: "A branch of the maxillary artery that is found in the gingiva, premolars, and molars." [ncithesaurus:Alveolar_Artery] +subset: human_reference_atlas xref: EMAPA:37069 {source="MA:th"} xref: MA:0001913 xref: NCIT:C52848 @@ -285414,12 +399565,21 @@ is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0011595 ! jaw region property_value: editor_note "add child terms" xsd:string +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0009655 +name: auricular artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001691 ! external ear +relationship: supplies UBERON:0001691 ! external ear [Term] id: UBERON:0009657 name: artery of lip namespace: uberon -synonym: "labial artery" EXACT [MA:0001987] +synonym: "labial artery" BROAD [MA:0001987] xref: EMAPA:37092 {source="MA:th"} xref: MA:0001987 xref: NCIT:C52947 @@ -285476,8 +399636,16 @@ xref: EHDAA2:0004566 xref: EMAPA:32911 xref: MA:0003203 is_a: UBERON:0002095 ! mesentery +relationship: located_in UBERON:0001179 {source="EHDAA2"} ! peritoneal cavity property_value: seeAlso https://github.com/obophenotype/uberon/issues/509 xsd:anyURI +[Term] +id: UBERON:0009668 +name: ventral mesentery +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002050 ! embryonic structure +relationship: part_of UBERON:0009664 ! gut mesentery + [Term] id: UBERON:0009669 name: embryonic cloacal lumen @@ -285501,6 +399669,7 @@ xref: EHDAA2:0004587 xref: EMAPA:18388 xref: FMA:14598 xref: http://www.snomedbrowser.com/Codes/Details/259740004 +xref: SCTID:259740004 is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space @@ -285511,6 +399680,24 @@ relationship: luminal_space_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0012465 {source="cjm"} ! lumen of terminal part of digestive tract +[Term] +id: UBERON:0009671 +name: nasal fin +is_a: UBERON:0005384 ! nasal cavity epithelium +is_a: UBERON:0011642 ! oral epithelium from ectoderm +relationship: existence_ends_during UBERON:0000068 ! embryo stage + +[Term] +id: UBERON:0009672 +name: oronasal membrane +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: develops_from UBERON:0009671 ! nasal fin +relationship: part_of UBERON:0000166 ! oral opening +relationship: part_of UBERON:0005384 ! nasal cavity epithelium + [Term] id: UBERON:0009676 name: early telencephalic vesicle @@ -285540,6 +399727,8 @@ xref: TAO:0001667 xref: ZFA:0001642 is_a: UBERON:0003672 ! dentition is_a: UBERON:0034926 ! anatomical row +intersection_of: UBERON:0034926 ! anatomical row +intersection_of: has_member UBERON:0001091 ! calcareous tooth [Term] id: UBERON:0009679 @@ -285554,8 +399743,9 @@ synonym: "mandibular dental arcade" RELATED [FMA:55635] synonym: "set of all lower teeth" EXACT [FMA:55635] xref: EHDAA2:0001029 xref: FMA:55635 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0009678 ! tooth row +intersection_of: UBERON:0009678 ! tooth row +intersection_of: part_of UBERON:0003278 ! skeleton of lower jaw relationship: part_of UBERON:0003278 ! skeleton of lower jaw [Term] @@ -285571,10 +399761,72 @@ synonym: "upper dental arcade" EXACT [FMA:55634] synonym: "upper jaw teeth" EXACT [EHDAA2:0002129] xref: EHDAA2:0002129 xref: FMA:55634 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0009678 ! tooth row +intersection_of: UBERON:0009678 ! tooth row +intersection_of: part_of UBERON:0003277 ! skeleton of upper jaw relationship: part_of UBERON:0003277 ! skeleton of upper jaw +[Term] +id: UBERON:0009692 +name: lumen of pharyngotympanic tube +is_a: UBERON:0002558 ! organ cavity +is_a: UBERON:0005082 ! tube lumen +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: continuous_with UBERON:0010060 ! pharyngeal opening of pharyngotympanic tube +relationship: developmentally_replaces UBERON:0005625 ! tubotympanic recess lumen +relationship: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: surrounded_by UBERON:0010062 ! pharyngotympanic tube epithelium + +[Term] +id: UBERON:0009695 +name: epithelium of laryngopharynx +is_a: UBERON:0003351 ! pharyngeal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001051 ! hypopharynx + +[Term] +id: UBERON:0009697 +name: epithelium of appendix +is_a: UBERON:0001278 ! epithelium of large intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: develops_from UBERON:0005636 ! caecum epithelium +relationship: part_of UBERON:0004989 ! mucosa of appendix + +[Term] +id: UBERON:0009708 +name: dorsal pancreas +namespace: uberon +subset: human_reference_atlas +subset: organ_slim +synonym: "pancreatis dorsalis" RELATED [] +xref: EHDAA2:0001371 +is_a: UBERON:0002365 {source="EHDAA2"} ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: develops_from UBERON:0010375 {source="EHDAA2"} ! pancreas dorsal primordium +relationship: has_developmental_contribution_from UBERON:0003923 {source="cjm"} ! dorsal pancreatic bud +relationship: part_of UBERON:0001264 {source="EHDAA2"} ! pancreas +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0009709 +name: ventral pancreas +namespace: uberon +subset: human_reference_atlas +subset: organ_slim +synonym: "pancreatis ventralis" RELATED [] +xref: EHDAA2:0001393 +is_a: UBERON:0002365 {source="EHDAA2"} ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: develops_from UBERON:0010376 {source="EHDAA2"} ! pancreas ventral primordium +relationship: has_developmental_contribution_from UBERON:0003924 {source="cjm"} ! ventral pancreatic bud +relationship: part_of UBERON:0001264 {source="EHDAA2"} ! pancreas +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0009712 name: endocardium of right ventricle @@ -285590,6 +399842,7 @@ xref: FMA:9536 xref: NCIT:C102343 xref: SCTID:8911002 xref: VHOG:0001235 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001081 ! endocardium of ventricle is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001081 ! endocardium of ventricle @@ -285613,6 +399866,7 @@ xref: EMAPA:17338 xref: FMA:9559 xref: SCTID:191004004 xref: VHOG:0001233 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: part_of UBERON:0002084 ! heart left ventricle @@ -285675,6 +399929,7 @@ def: "The cavity of the developing embryo that is formed within the epiblast tis subset: pheno_slim xref: EMAPA:36038 is_a: UBERON:0002553 ! anatomical cavity +relationship: only_in_taxon NCBITaxon:32524 ! Amniota relationship: part_of UBERON:0000922 ! embryo [Term] @@ -285693,6 +399948,7 @@ name: lymph node medullary sinus namespace: uberon def: "The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels." [MP:0011222] comment: Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells.[WP] +subset: human_reference_atlas subset: pheno_slim synonym: "lymph node medullary sinusoid" RELATED [] synonym: "medullary sinus" BROAD [] @@ -285700,19 +399956,24 @@ xref: EMAPA:37898 {source="MA:th"} xref: FMA:312359 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004111 ! anatomical conduit +relationship: channel_for UBERON:0002391 ! lymph relationship: part_of UBERON:0002007 ! medulla of lymph node +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009745 name: lymph node medullary cord namespace: uberon def: "The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node." [MP:0011224] +subset: human_reference_atlas subset: pheno_slim synonym: "medullary cord" BROAD [] xref: EMAPA:37897 {source="MA:th"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 ! organ part +relationship: adjacent_to UBERON:0009744 ! lymph node medullary sinus relationship: part_of UBERON:0002007 ! medulla of lymph node +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009746 @@ -285785,11 +400046,15 @@ name: pancreas mesenchyme namespace: uberon def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." [MP:0011265] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim xref: EFO:0002557 xref: EMAPA:26220 is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0001264 ! pancreas +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009753 @@ -285828,6 +400093,10 @@ synonym: "PIP joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand xref: FMA:65022 xref: NCIT:C101528 is_a: UBERON:0006658 ! interphalangeal joint +intersection_of: UBERON:0006658 ! interphalangeal joint +intersection_of: connects UBERON:0004302 ! proximal phalanx +relationship: connects UBERON:0004301 ! middle phalanx +relationship: connects UBERON:0004302 ! proximal phalanx [Term] id: UBERON:0009768 @@ -285840,6 +400109,9 @@ synonym: "DIP joint" NARROW [Wikipedia:Interphalangeal_articulations_of_the_hand xref: FMA:65024 xref: NCIT:C101529 is_a: UBERON:0006658 ! interphalangeal joint +intersection_of: UBERON:0006658 ! interphalangeal joint +intersection_of: connects UBERON:0004300 ! distal phalanx +relationship: connects UBERON:0004300 ! distal phalanx [Term] id: UBERON:0009773 @@ -285852,6 +400124,7 @@ synonym: "renal tubule (generic)" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "tubule of excretory system" EXACT [https://orcid.org/0000-0002-6601-2165, OBOL:automatic] is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0006555 ! excretory tube +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria property_value: IAO:0000232 "this class groups vertebrate nephron tubules with analagous structures such as insect Malpighian tubules" xsd:string [Term] @@ -285922,7 +400195,6 @@ synonym: "acinus" BROAD [FMA:55588] xref: FMA:55588 xref: http://en.wikipedia.org/wiki/Acinus xref: Wikipedia:Acinus -is_a: BFO:0000040 ! material entity is_a: UBERON:0034922 ! cell cluster intersection_of: UBERON:0034922 ! cell cluster intersection_of: has_part CL:0000151 ! secretory cell @@ -285934,6 +400206,15 @@ relationship: part_of UBERON:0002530 ! gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png xsd:anyURI property_value: UBPROP:0000007 "acinar" xsd:string +[Term] +id: UBERON:0009843 +name: prostate epithelial cord +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005154 ! epithelial cord +intersection_of: UBERON:0005154 ! epithelial cord +intersection_of: has_potential_to_develop_into UBERON:0002367 ! prostate gland +relationship: has_potential_to_develop_into UBERON:0002367 ! prostate gland + [Term] id: UBERON:0009844 name: urogenital sinus lumen @@ -285985,10 +400266,15 @@ name: prostate field namespace: uberon def: "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GO:0060515, GOC:dph, PMID:18977204] synonym: "prostate primordium" RELATED [] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007688 ! anlage +intersection_of: UBERON:0007688 ! anlage +intersection_of: has_potential_to_develop_into UBERON:0002367 ! prostate gland +relationship: developmentally_induced_by UBERON:0009845 ! urogenital sinus mesenchyme +relationship: has_potential_to_develop_into UBERON:0002367 ! prostate gland relationship: part_of UBERON:0004902 {source="PMID:18977204"} ! urogenital sinus epithelium [Term] @@ -286012,6 +400298,9 @@ synonym: "diverticulum" RELATED [] synonym: "pouch" EXACT [] xref: galen:Diverticulum is_a: UBERON:0000061 ! anatomical structure +intersection_of: UBERON:0000061 ! anatomical structure +intersection_of: has_quality PATO:0001987 ! saccular +relationship: has_quality PATO:0001987 ! saccular [Term] id: UBERON:0009870 @@ -286065,8 +400354,13 @@ synonym: "metacarpus/metatarsus region" EXACT [] synonym: "metapodial segment" EXACT [] synonym: "metapodium" RELATED [] xref: SCTID:370640001 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0002529 ! limb segment +intersection_of: UBERON:0002529 ! limb segment +intersection_of: has_skeleton UBERON:0010546 ! metapodial skeleton +relationship: has_skeleton UBERON:0010546 ! metapodial skeleton relationship: part_of UBERON:0012140 {source="PHENOSCAPE:ni"} ! digitopodium region +relationship: proximally_connected_to UBERON:0006716 ! mesopodium region property_value: editor_note "considering adding 'acropodial region'" xsd:string property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group" xsd:string @@ -286083,10 +400377,16 @@ synonym: "mesopodium" RELATED [VSAO:0005022, VSAO:NI] synonym: "mesopodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeletal parts of mesopodium" EXACT [https://orcid.org/0000-0002-6601-2165] xref: VSAO:0005022 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0006716 ! mesopodium region +relationship: distally_connected_to UBERON:0010546 ! metapodial skeleton relationship: part_of UBERON:0006716 ! mesopodium region relationship: part_of UBERON:0006717 ! autopodial skeleton +relationship: proximally_connected_to UBERON:0011584 ! zeugopodial skeleton +relationship: skeleton_of UBERON:0006716 ! mesopodium region property_value: UBPROP:0000001 "Limb skeleton subdivision consisting of endochondral bones increasing the freedom of movement of the autopodia, and located between zeugopodia and autopodia.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005022", ontology="VSAO", source="VSAO:NI"} property_value: UBPROP:0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005022", ontology="VSAO"} @@ -286119,8 +400419,13 @@ xref: VSAO:0005024 xref: Wikipedia:Tarsus_(skeleton) xref: XAO:0003211 is_a: UBERON:0009878 ! mesopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0004454 ! tarsal region +relationship: distally_connected_to UBERON:0010545 ! metatarsus skeleton relationship: part_of UBERON:0001445 ! skeleton of pes relationship: part_of UBERON:0004454 ! tarsal region +relationship: proximally_connected_to UBERON:0010720 ! hindlimb zeugopod skeleton +relationship: skeleton_of UBERON:0004454 ! tarsal region property_value: UBPROP:0000001 "Segment of the leg corresponding to the tarsus. It consists of several elements that articulate with the tibia and fibula at one end and the metatarsals at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000220", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001160", ontology="VHOG", source="DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", source="http://bgee.unil.ch/"} property_value: UBPROP:0000008 "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present" xsd:string {source="PHENOSCAPE:ad"} @@ -286151,8 +400456,13 @@ xref: VSAO:0005023 xref: Wikipedia:Carpus xref: XAO:0003207 is_a: UBERON:0009878 ! mesopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0004452 ! carpal region +relationship: distally_connected_to UBERON:0010544 ! metacarpus skeleton relationship: part_of UBERON:0001442 ! skeleton of manus relationship: part_of UBERON:0004452 ! carpal region +relationship: proximally_connected_to UBERON:0010703 ! forelimb zeugopod skeleton +relationship: skeleton_of UBERON:0004452 ! carpal region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg xsd:anyURI property_value: UBPROP:0000001 "Segment of the forearm corresponding to the carpus. It consists of several elements that articulate with the radius and ulna at one end and the metacarpals at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000201", ontology="AAO", source="AAO:LAP"} property_value: UBPROP:0000003 "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001161", ontology="VHOG", source="DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", source="http://bgee.unil.ch/"} @@ -286173,11 +400483,30 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: part_of UBERON:0003081 {source="ZFA"} ! lateral plate mesoderm +[Term] +id: UBERON:0009882 +name: anal column +namespace: uberon +def: "One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP]." [Wikipedia:Anal_columns] +synonym: "column of Morgagni" EXACT [FMA:15713] +synonym: "columnae anales" RELATED LATIN [Wikipedia:Anal_columns] +xref: FMA:15713 +xref: NCIT:C32067 +xref: SCTID:245444007 +xref: UMLS:C0227428 {source="ncithesaurus:Anal_Column"} +xref: Wikipedia:Anal_columns +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0034944 ! zone of organ +relationship: has_quality PATO:0001910 ! folded +relationship: part_of UBERON:0000159 ! anal canal +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png xsd:anyURI + [Term] id: UBERON:0009883 name: medullary ray namespace: uberon def: "A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla." [MP:0011347, Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy)] +subset: human_reference_atlas subset: pheno_slim synonym: "Ferrein's pyramid" EXACT [MP:0011347] synonym: "kidney medullary ray" EXACT [MP:0011347] @@ -286188,7 +400517,10 @@ xref: FMA:74299 xref: Wikipedia:Bone_marrow_of_ovaryry_ray_(anatomy) is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000064 {source="FMA"} ! organ part +relationship: contributes_to_morphology_of UBERON:0001225 ! cortex of kidney +relationship: overlaps UBERON:0001231 ! nephron tubule relationship: part_of UBERON:0001225 {source="MP"} ! cortex of kidney +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "FMA says parenchyma, MP says cortex" xsd:string {external_ontology="FMA"} property_value: UBPROP:0000013 "Their name is potentially misleading -- the 'medullary' refers to their destination, not their location. They are located only in the renal cortex, and not in the renal medulla" xsd:string @@ -286197,6 +400529,7 @@ id: UBERON:0009885 name: interlobar artery namespace: uberon def: "An artery that supplies a renal lobe." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Interlobar_arteries] +subset: human_reference_atlas subset: pheno_slim synonym: "arteriae interlobares renis" EXACT PLURAL [FMA:TA] synonym: "arteriae interlobares renis" RELATED LATIN [Wikipedia:Interlobar_arteries] @@ -286210,9 +400543,21 @@ xref: FMA:71637 xref: SCTID:62802007 xref: Wikipedia:Interlobar_arteries is_a: UBERON:0001637 ! artery -property_value: depicted:by Kidney:PioM.png xsd:anyURI +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0009913 ! renal lobe +relationship: supplies UBERON:0009913 ! renal lobe +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png xsd:anyURI +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000012 "FMA only has the set term" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0009887 +name: interlobar vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0009913 ! renal lobe +relationship: drains UBERON:0009913 ! renal lobe + [Term] id: UBERON:0009889 name: secondary heart field @@ -286229,7 +400574,7 @@ is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007688 ! anlage relationship: anterior_to UBERON:0004140 {source="PMID:17276708"} ! primary heart field relationship: dorsal_to UBERON:0004140 {source="PMID:17276708"} ! primary heart field -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0003081 {source="GO:0003129"} ! lateral plate mesoderm property_value: UBPROP:0000001 "extra-cardiac population of mesodermal progenitors that gives rise to the right ventricle and outflow tract[PMID:17276708]." xsd:string {source="PMID:17276708"} property_value: UBPROP:0000008 "In general, the two studies in chick concluded that the contribution of the SHF was to the outflow tract, whereas the mouse work suggested that the second lineage contributed more broadly to the heart, including the outflow tract and much or all of the right ventricle [11-14]. These different conclusions may represent differences in the experimental approaches used or may represent bona fide differences in the contribution of the second lineage to the hearts of birds compared to mammals [11]. Alternatively, the secondary/anterior heart fields described in the chick may represent a subset of a broader field that makes a more substantial contribution to the heart, as the mouse studies suggested" xsd:string {source="PMID:17276708"} @@ -286289,8 +400634,11 @@ xref: UMLS:C0736382 {source="ncithesaurus:Kidney_Lower_Lobe"} xref: Wikipedia:Renal_lobe is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0009912 ! anatomical lobe +intersection_of: UBERON:0009912 ! anatomical lobe +intersection_of: part_of UBERON:0002113 ! kidney +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney -property_value: depicted:by Kidney:PioM.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png xsd:anyURI property_value: editor_note "todo - add has_part relationships." xsd:string property_value: UBPROP:0000008 "human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys" xsd:string {source="MP"} @@ -286316,6 +400664,11 @@ xref: SCTID:361330004 xref: Wikipedia:Cortical_lobule is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0009911 ! lobule +intersection_of: UBERON:0009911 ! lobule +intersection_of: part_of UBERON:0002113 ! kidney +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney +relationship: has_part UBERON:0001285 ! nephron +relationship: has_part UBERON:0009883 ! medullary ray relationship: part_of UBERON:0009913 {source="FMA"} ! renal lobe [Term] @@ -286327,7 +400680,6 @@ synonym: "ureteral wall" EXACT [FMA:15888] xref: FMA:15888 xref: http://www.snomedbrowser.com/Codes/Details/279397004 xref: SCTID:279397004 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -286345,6 +400697,12 @@ subset: pheno_slim xref: EMAPA:37886 {source="MA:th"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0007651 ! anatomical junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: adjacent_to UBERON:0000362 ! renal medulla +intersection_of: adjacent_to UBERON:0001225 ! cortex of kidney +relationship: adjacent_to UBERON:0000362 ! renal medulla +relationship: adjacent_to UBERON:0001225 ! cortex of kidney +relationship: contributes_to_morphology_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 {source="MP"} ! kidney [Term] @@ -286364,6 +400722,7 @@ name: ureter smooth muscle namespace: uberon def: "The smooth muscle tissue surrounding the epithelium of the ureter" [MP:0011426] def: "The smooth muscle tissue surrounding the epithelium of the ureter." [MP:0011426] +subset: human_reference_atlas subset: pheno_slim synonym: "ureteral smooth muscle" EXACT [MP:0011426] synonym: "ureteral smooth muscle layer" EXACT [EMAPA:28844] @@ -286373,6 +400732,7 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0000056 ! ureter relationship: contributes_to_morphology_of UBERON:0000056 ! ureter relationship: part_of UBERON:0006855 ! muscular coat of ureter +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009920 @@ -286466,6 +400826,37 @@ relationship: develops_from UBERON:0009844 {source="EHDAA2"} ! urogenital sinus relationship: luminal_space_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 {source="FMA"} ! urinary bladder +[Term] +id: UBERON:0009959 +name: lumen of oropharynx +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001729 ! oropharynx +relationship: develops_from UBERON:0006272 ! oronasal cavity +relationship: luminal_space_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001731 ! cavity of pharynx + +[Term] +id: UBERON:0009970 +name: epithelium of pancreatic duct +namespace: uberon +def: "An epithelium that is part of a pancreatic duct." [OBOL:automatic] +subset: efo_slim +synonym: "pancreatic duct epithelium" EXACT [FMA:67681] +synonym: "pancreatic ductal epithelium" EXACT [FMA:67681] +xref: EFO:0002556 +xref: FMA:67681 +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0013697 ! exocrine pancreas epithelium +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0007329 ! pancreatic duct +relationship: part_of UBERON:0007329 ! pancreatic duct +property_value: editor_note "in EHDAA2, the embryonic pancreatic ducts (dorsal, ventral) are classified as eithelial sacs, which would render them subclasses of this" xsd:string + [Term] id: UBERON:0009972 name: ureteropelvic junction @@ -286516,6 +400907,18 @@ relationship: connects UBERON:0001255 ! urinary bladder relationship: contributes_to_morphology_of UBERON:0001008 ! renal system relationship: part_of UBERON:0001008 {source="MP"} ! renal system +[Term] +id: UBERON:0009974 +name: lumen of Rathke's pouch +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005082 ! tube lumen +is_a: UBERON:0007473 ! lumen of epithelial sac +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0005356 ! Rathke's pouch +relationship: luminal_space_of UBERON:0005356 ! Rathke's pouch +relationship: part_of UBERON:0005356 ! Rathke's pouch +relationship: surrounded_by UBERON:0012287 ! Rathkes pouch epithelium + [Term] id: UBERON:0010000 name: multicellular anatomical structure @@ -286565,6 +400968,7 @@ subset: pheno_slim synonym: "placental labyrinth villi" RELATED PLURAL [] synonym: "villous of placental labyrinth" EXACT [] is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: contributes_to_morphology_of UBERON:0003946 ! placenta labyrinth relationship: part_of UBERON:0003946 {source="MP"} ! placenta labyrinth [Term] @@ -286598,6 +401002,10 @@ xref: FMA:256381 xref: NLXANAT:20090509 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034923 ! disconnected anatomical group +intersection_of: UBERON:0034923 ! disconnected anatomical group +intersection_of: has_member UBERON:0002616 ! regional part of brain +intersection_of: part_of UBERON:0000955 ! brain +relationship: has_member UBERON:0002616 ! regional part of brain relationship: part_of UBERON:0000955 ! brain property_value: editor_note "May be obsoleted." xsd:string @@ -286606,6 +401014,7 @@ id: UBERON:0010011 name: collection of basal ganglia namespace: uberon def: "Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum." [BIRNLEX:826] +subset: human_reference_atlas subset: pheno_slim synonym: "basal ganglia" EXACT [FMA:84013] synonym: "basal ganglia set" EXACT [FMA:84013] @@ -286624,21 +401033,33 @@ xref: FMA:84013 xref: GAID:617 xref: HBA:4275 xref: HBA:4276 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2677 xref: MA:0000184 xref: MBA:623 -xref: MESH:A08.186.211.730.885.105 +xref: MESH:D001479 xref: NCIT:C12447 +xref: neuronames:2677 xref: PBA:128012596 xref: PBA:4001 xref: UMLS:C0004781 {source="ncithesaurus:Basal_Ganglia"} xref: VHOG:0001696 xref: Wikipedia:Basal_ganglia is_a: UBERON:0010009 {source="FMA"} ! aggregate regional part of brain +relationship: overlaps UBERON:0001891 ! midbrain +relationship: overlaps UBERON:0001893 ! telencephalon relationship: part_of UBERON:0000454 {source="FMA"} ! cerebral subcortex property_value: editor_note "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the collection of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." xsd:string +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000003 "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001696", ontology="VHOG", source="DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0010020 +name: tubotympanic recess epithelium +is_a: UBERON:0005423 ! developing anatomical structure +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0015813 ! middle ear epithelium +relationship: develops_from UBERON:0007122 ! pharyngeal pouch 1 + [Term] id: UBERON:0010023 name: dorsal part of pharyngeal pouch 2 @@ -286695,7 +401116,7 @@ intersection_of: develops_from UBERON:0006260 {source="ISBN:1607950324"} ! lingu intersection_of: part_of UBERON:0001723 {source="ISBN:1607950324"} ! tongue relationship: develops_from UBERON:0006260 ! lingual swellings relationship: part_of UBERON:0001723 ! tongue -property_value: depicted:by Illu04:tongue.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg xsd:anyURI property_value: UBPROP:0000011 "The lateral lingual swellings grow and fuse with eachother, encompassing the tuberculum impar to provide the ectodermally derived mucosa of the anterior 2/3 of the tongue" xsd:string property_value: UBPROP:0000012 "check NCIT" xsd:string {external_ontology="NCIT"} @@ -286728,7 +401149,7 @@ xref: Wikipedia:Posterior_tongue is_a: UBERON:0000064 ! organ part is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0009471 {source="FMA"} ! dorsum of tongue -property_value: depicted:by Illu04:tongue.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg xsd:anyURI [Term] id: UBERON:0010038 @@ -286748,6 +401169,8 @@ xref: UMLS:C0017130 {source="ncithesaurus:Fundic_Gland"} xref: Wikipedia:Fundic_glands is_a: UBERON:0000325 ! gastric gland is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000325 ! gastric gland +intersection_of: part_of UBERON:0001160 ! fundus of stomach relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/d7/Fundic_gland_polyp_%281%29.jpg xsd:anyURI property_value: editor_note "Consider FMA:14923 ! Principal gland of fundus of stomach. Added part_of to mucosa to be consistent with FMA pattern (note that Kardong places this in the glandular epithelium)" xsd:string @@ -286805,6 +401228,8 @@ synonym: "mesenchyme of maxillary component" EXACT [EMAPA:16391] xref: EHDAA2:0000041 xref: EMAPA:16391 is_a: UBERON:0010042 ! 1st arch mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0007238 ! 1st arch maxillary component relationship: part_of UBERON:0007238 ! 1st arch maxillary component [Term] @@ -286911,6 +401336,38 @@ xref: EHDAA2:0004610 is_a: UBERON:0002036 {source="EHDAA2"} ! striated muscle tissue relationship: part_of UBERON:0010056 {source="EHDAA2"} ! future tongue +[Term] +id: UBERON:0010060 +name: pharyngeal opening of pharyngotympanic tube +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +relationship: continuous_with UBERON:0010061 ! lumen of nasopharynx +relationship: part_of UBERON:0001042 ! chordate pharynx + +[Term] +id: UBERON:0010061 +name: lumen of nasopharynx +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +relationship: part_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001731 ! cavity of pharynx + +[Term] +id: UBERON:0010062 +name: pharyngotympanic tube epithelium +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0015813 ! middle ear epithelium +relationship: part_of UBERON:0002393 ! pharyngotympanic tube + +[Term] +id: UBERON:0010063 +name: tympanic cavity epithelium +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0015813 ! middle ear epithelium +relationship: located_in UBERON:0004114 ! tympanic cavity + [Term] id: UBERON:0010064 name: open anatomical space @@ -286919,6 +401376,42 @@ def: "An anatomical space with at least one opening to another space or the exte xref: AEO:0000221 xref: EHDAA2:0004616 is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: has_quality PATO:0000610 ! open +relationship: connected_to UBERON:0000464 ! anatomical space +relationship: has_quality PATO:0000610 ! open + +[Term] +id: UBERON:0010065 +name: auditory meatus epithelium +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0015814 ! outer ear epithelium +relationship: develops_from UBERON:0005872 ! 1st arch pharyngeal cleft + +[Term] +id: UBERON:0010069 +name: outer epithelial layer of tympanic membrane +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0009647 ! tympanic membrane epithelium +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0015814 ! outer ear epithelium +intersection_of: UBERON:0009647 ! tympanic membrane epithelium +intersection_of: part_of UBERON:0001352 ! external acoustic meatus +relationship: part_of UBERON:0001352 ! external acoustic meatus + +[Term] +id: UBERON:0010070 +name: intermediate layer of tympanic membrane +is_a: UBERON:0010071 ! layer of tympanic membrane + +[Term] +id: UBERON:0010071 +name: layer of tympanic membrane +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: part_of UBERON:0002364 ! tympanic membrane [Term] id: UBERON:0010074 @@ -286931,6 +401424,7 @@ xref: FMA:79645 xref: MESH:D002838 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011216 ! organ system subdivision +relationship: composed_primarily_of CL:0000166 ! chromaffin cell relationship: part_of UBERON:0000949 {source="cjm"} ! endocrine system property_value: UBPROP:0000008 "in adult cylostomes and teleosts, the interrenal bodies are separate from chromaffin bodies" xsd:string @@ -286966,10 +401460,11 @@ namespace: uberon def: "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." [OBOL:automatic] xref: EHDAA2:0000595 is_a: UBERON:0003703 ! extrahepatic bile duct -is_a: UBERON:0005911 ! endo-epithelium -is_a: UBERON:0034932 ! epithelium of biliary system -is_a: UBERON:0034969 ! epithelial layer of duct +is_a: UBERON:0004822 ! extrahepatic bile duct epithelium +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: has_potential_to_develop_into UBERON:0001175 ! common hepatic duct relationship: develops_from UBERON:0005604 ! extrahepatic part of hepatic duct +relationship: has_potential_to_develop_into UBERON:0001175 ! common hepatic duct [Term] id: UBERON:0010083 @@ -286993,6 +401488,7 @@ name: future diaphragm namespace: uberon def: "A structure that will develop into a diaphragm." [http://orcid.org/0000-0002-6601-2165] xref: EHDAA2:0000599 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: has_potential_to_develop_into UBERON:0001103 ! diaphragm @@ -287010,6 +401506,9 @@ xref: EHDAA2:0000608 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0007524 ! dense mesenchyme tissue +intersection_of: UBERON:0006598 ! presumptive structure +intersection_of: has_potential_to_develop_into UBERON:0006059 ! falx cerebri +relationship: has_potential_to_develop_into UBERON:0006059 ! falx cerebri [Term] id: UBERON:0010091 @@ -287059,6 +401558,9 @@ namespace: uberon def: "A gray matter that has the potential to develop into a facial nucleus." [OBOL:automatic] xref: EHDAA2:0004639 is_a: UBERON:0002020 ! gray matter +intersection_of: UBERON:0002020 ! gray matter +intersection_of: has_potential_to_develop_into UBERON:0000127 ! facial nucleus +relationship: has_potential_to_develop_into UBERON:0000127 ! facial nucleus [Term] id: UBERON:0010125 @@ -287098,7 +401600,10 @@ is_a: UBERON:0005254 ! upper leg mesenchyme is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015052 ! femur endochondral element +intersection_of: UBERON:0015052 ! femur endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006234 ! femur pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0000981 ! femur property_value: editor_note "TODO - request EHDAA2" xsd:string [Term] @@ -287109,7 +401614,10 @@ def: "The distal elements of the developing limb of vertebrates that will give r synonym: "autopod plate" EXACT [] synonym: "limb plate" EXACT [] is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0002050 ! embryonic structure +intersection_of: has_potential_to_develop_into UBERON:0002470 ! autopod region relationship: develops_from UBERON:0004347 ! limb bud +relationship: has_potential_to_develop_into UBERON:0002470 ! autopod region [Term] id: UBERON:0010131 @@ -287144,10 +401652,12 @@ namespace: uberon def: "A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim xref: EMAPA:35759 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2857 xref: MA:0002943 +xref: neuronames:2857 is_a: UBERON:0005408 {source="MA"} ! circumventricular organ is_a: UBERON:0010133 {source="MA"} ! neuroendocrine gland +intersection_of: UBERON:0005408 ! circumventricular organ +intersection_of: part_of UBERON:0000949 ! endocrine system [Term] id: UBERON:0010135 @@ -287163,9 +401673,11 @@ synonym: "sensitive organs" RELATED PLURAL [NeuroNames:2856] synonym: "sensory circumventricular organs" RELATED [NeuroNames:2856] synonym: "sensory CVOs" RELATED PLURAL [NeuroNames:2856] xref: EMAPA:37741 {source="MA:th"} -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2856 xref: MA:0002944 +xref: neuronames:2856 is_a: UBERON:0005408 ! circumventricular organ +intersection_of: UBERON:0005408 ! circumventricular organ +intersection_of: part_of UBERON:0001032 ! sensory system relationship: part_of UBERON:0001032 ! sensory system [Term] @@ -287214,6 +401726,9 @@ xref: NCIT:C52552 xref: UMLS:C0036614 {source="ncithesaurus:Seminal_Fluid"} xref: UMLS:C0227987 {source="ncithesaurus:Seminal_Vesicle_Secretion"} is_a: UBERON:0006530 {source="FMA"} ! seminal fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: produced_by UBERON:0000998 ! seminal vesicle +relationship: produced_by UBERON:0000998 ! seminal vesicle property_value: UBPROP:0000008 "constitutes 60-70 % of the ejaculate in humans[MP]" xsd:string property_value: UBPROP:0000009 "important for semen coagulation, sperm motility, and stability of sperm chromatin and suppression of the immune activity in the female reproductive tract[MP]" xsd:string property_value: UBPROP:0000012 "in ncit, seminal fluid is a subtype of seminal vesicle secretion" xsd:string {external_ontology="ncit"} @@ -287247,9 +401762,20 @@ xref: UMLS:C0221315 {source="ncithesaurus:Paraurethral_Gland"} xref: Wikipedia:Skene%27s_gland is_a: UBERON:0005398 ! female reproductive gland relationship: part_of UBERON:0000997 {source="FMA"} ! mammalian vulva -property_value: depicted:by Skenes:gland.jpg xsd:anyURI +relationship: sexually_homologous_to UBERON:0002367 ! prostate gland +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/b8/Skenes_gland.jpg xsd:anyURI property_value: UBPROP:0000012 "in MP female urethral gland, Skene gland and paraurethral gland are exact syns. Note that NCITA seems to use the term in a more generic way, as a parent for skene gland, cowper gland (which may be the same as the male bulbo-urethral gland)" xsd:string {external_ontology="MP"} +[Term] +id: UBERON:0010146 +name: paraurethral duct +is_a: UBERON:0000058 ! duct +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0010145 ! paraurethral gland +relationship: part_of UBERON:0010145 ! paraurethral gland +relationship: sexually_homologous_to UBERON:0002485 ! prostate duct + [Term] id: UBERON:0010147 name: male accessory sex gland @@ -287261,6 +401787,25 @@ synonym: "male accessory reproductive gland" RELATED [] xref: BTO:0004798 is_a: UBERON:0005399 {source="BTO"} ! male reproductive gland +[Term] +id: UBERON:0010150 +name: duct of major vestibular gland +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0011831 ! duct of vestibular gland +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0000460 ! major vestibular gland +relationship: part_of UBERON:0000460 ! major vestibular gland +relationship: sexually_homologous_to UBERON:0010151 ! duct of bulbourethral gland + +[Term] +id: UBERON:0010151 +name: duct of bulbourethral gland +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005904 ! duct of male reproductive system +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0002366 ! bulbo-urethral gland +relationship: part_of UBERON:0002366 ! bulbo-urethral gland + [Term] id: UBERON:0010152 name: skin mucus @@ -287353,6 +401898,16 @@ xref: Wikipedia:Occipitomastoid_suture is_a: UBERON:0003685 {source="FMA"} ! cranial suture property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/d/df/Occipitomastoideus.PNG xsd:anyURI +[Term] +id: UBERON:0010160 +name: lumen of lymphatic vessel +is_a: BFO:0000141 ! immaterial entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001473 ! lymphatic vessel +relationship: luminal_space_of UBERON:0001473 ! lymphatic vessel +relationship: part_of UBERON:0001473 ! lymphatic vessel + [Term] id: UBERON:0010161 name: lumen of blood vessel @@ -287382,6 +401937,9 @@ xref: EMAPA:37760 {source="MA:th"} xref: MA:0002848 xref: XAO:0004057 is_a: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: distalmost_part_of UBERON:0007812 ! post-anal tail +relationship: distalmost_part_of UBERON:0007812 ! post-anal tail relationship: part_of UBERON:0007812 {source="MA"} ! post-anal tail [Term] @@ -287400,7 +401958,7 @@ xref: UMLS:C0015420 {source="ncithesaurus:Eyebrow"} xref: Wikipedia:Eyebrow is_a: UBERON:0010165 {source="FMA"} ! collection of hair on face relationship: part_of UBERON:0035639 ! ocular adnexa -property_value: depicted:by Eyes:chris.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/29/Eyes_chris.jpg xsd:anyURI property_value: UBPROP:0000012 "in NCIT, this is an 'eye appendage'" xsd:string {external_ontology="ncit"} [Term] @@ -287413,7 +401971,12 @@ synonym: "hairs set" EXACT [FMA:70752] synonym: "pili" EXACT LATIN [FMA:TA] synonym: "set of hairs" EXACT [FMA:70752] xref: FMA:70752 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034925 ! anatomical collection +intersection_of: UBERON:0034925 ! anatomical collection +intersection_of: has_member UBERON:0001037 ! strand of hair +relationship: has_member UBERON:0001037 ! strand of hair +relationship: has_quality PATO:0010001 ! disconnected [Term] id: UBERON:0010165 @@ -287426,6 +401989,9 @@ synonym: "facial hairs set" EXACT [FMA:70741] synonym: "set of facial hairs" EXACT [FMA:70741] xref: FMA:70741 is_a: UBERON:0014382 ! collection of hairs on head or neck +intersection_of: UBERON:0010164 ! collection of hairs +intersection_of: part_of UBERON:0001456 ! face +relationship: has_member UBERON:0010171 ! strand of hair of face relationship: part_of UBERON:0001456 ! face [Term] @@ -287466,6 +402032,8 @@ synonym: "hair of face" EXACT [FMA:54360] xref: FMA:54360 xref: SCTID:368910000 is_a: UBERON:0016446 ! hair of head +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0001456 ! face relationship: part_of UBERON:0001456 ! face [Term] @@ -287487,6 +402055,7 @@ xref: SCTID:362032000 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: contributes_to_morphology_of UBERON:0001496 ! ascending aorta relationship: part_of UBERON:0001496 {source="FMA"} ! ascending aorta property_value: UBPROP:0000001 "The dilated first part of the aorta containing the aortic semilunar valves and the aortic sinuses." xsd:string {source="http://medical-dictionary.thefreedictionary.com/aortic+bulb"} @@ -287503,6 +402072,15 @@ is_a: UBERON:0007651 ! anatomical junction is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0001496 {source="MP"} ! ascending aorta +[Term] +id: UBERON:0010183 +name: liver trabecula +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: part_of UBERON:0002107 ! liver +relationship: part_of UBERON:0002107 ! liver + [Term] id: UBERON:0010185 name: rete ovarii @@ -287542,8 +402120,18 @@ xref: SCTID:303562001 xref: UMLS:C1314737 {source="ncithesaurus:Urethral_Gland"} xref: Wikipedia:Urethral_gland is_a: UBERON:0001338 ! urethral gland +intersection_of: UBERON:0001338 ! urethral gland +intersection_of: part_of UBERON:0001333 ! male urethra relationship: part_of UBERON:0001333 ! male urethra +[Term] +id: UBERON:0010187 +name: female urethral gland +is_a: UBERON:0001338 ! urethral gland +intersection_of: UBERON:0001338 ! urethral gland +intersection_of: part_of UBERON:0001334 ! female urethra +relationship: part_of UBERON:0001334 ! female urethra + [Term] id: UBERON:0010188 name: protuberance @@ -287555,6 +402143,14 @@ xref: FMA:82506 is_a: UBERON:0034944 {source="FMA"} ! zone of organ property_value: editor_note "requires review" xsd:string +[Term] +id: UBERON:0010189 +name: right atrium venous valve +is_a: UBERON:0005208 ! right atrium valve +is_a: UBERON:0006675 ! venous valve +intersection_of: UBERON:0006675 ! venous valve +intersection_of: part_of UBERON:0002078 ! right cardiac atrium + [Term] id: UBERON:0010190 name: pair of dorsal aortae @@ -287565,7 +402161,9 @@ synonym: "paired dorsal aortae" EXACT [EHDAA2:0000410] xref: EHDAA2:0000410 xref: EMAPA:18606 xref: MA:0000476 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000481 {source="EHDAA2"} ! multi-tissue structure +relationship: has_part UBERON:0005805 ! dorsal aorta relationship: part_of UBERON:0010191 {source="EHDAA2"} ! aortic system [Term] @@ -287574,7 +402172,7 @@ name: aortic system namespace: uberon xref: EHDAA2:0004512 is_a: UBERON:0011216 ! organ system subdivision -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0004571 {source="Wikipedia"} ! systemic arterial system [Term] @@ -287598,6 +402196,8 @@ synonym: "hepatic-portal system" EXACT [AAO:0010225] synonym: "portal system of liver" EXACT [] xref: AAO:0010225 is_a: UBERON:0005806 ! portal system +relationship: connects UBERON:0001555 ! digestive tract +relationship: connects UBERON:0002107 ! liver property_value: UBPROP:0000001 "Part of the circulatory system which includes the ventral abdominal vein, pelvic veins, and portal vein and collects blood from the pelvic region, liver, gall bladder and stomach.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010225", ontology="AAO", source="AAO:BJB"} [Term] @@ -287624,6 +402224,15 @@ subset: upper_level xref: CARO:0001004 is_a: UBERON:0000466 {source="CARO"} ! immaterial anatomical entity +[Term] +id: UBERON:0010204 +name: tail vasculature +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0010207 name: nictitating membrane @@ -287744,10 +402353,30 @@ namespace: uberon subset: pheno_slim synonym: "inter-pupillary line" EXACT [] synonym: "interpupillary line" EXACT [] -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006800 ! anatomical line +intersection_of: UBERON:0006800 ! anatomical line +intersection_of: connects UBERON:0010223 ! left pupil +intersection_of: connects UBERON:0010224 ! right pupil +relationship: connects UBERON:0010223 ! left pupil +relationship: connects UBERON:0010224 ! right pupil relationship: part_of UBERON:0001456 ! face +[Term] +id: UBERON:0010223 +name: left pupil +is_a: UBERON:0001771 ! pupil +intersection_of: UBERON:0001771 ! pupil +intersection_of: part_of UBERON:0004548 ! left eye +relationship: part_of UBERON:0004548 ! left eye + +[Term] +id: UBERON:0010224 +name: right pupil +is_a: UBERON:0001771 ! pupil +intersection_of: UBERON:0001771 ! pupil +intersection_of: part_of UBERON:0004549 ! right eye +relationship: part_of UBERON:0004549 ! right eye + [Term] id: UBERON:0010225 name: thalamic complex @@ -287806,6 +402435,21 @@ synonym: "inter-otic line" RELATED [] synonym: "inter-pinna line" RELATED [] synonym: "otic line" RELATED [] is_a: UBERON:0006800 ! anatomical line +intersection_of: UBERON:0006800 ! anatomical line +intersection_of: connects UBERON:0006616 ! right external ear +intersection_of: connects UBERON:0006617 ! left external ear +relationship: connects UBERON:0006616 ! right external ear +relationship: connects UBERON:0006617 ! left external ear + +[Term] +id: UBERON:0010233 +name: stroma of thyroid gland +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland [Term] id: UBERON:0010234 @@ -287842,7 +402486,14 @@ synonym: "uvular muscle" EXACT [FMA:46733] xref: FMA:46733 xref: SCTID:244797009 xref: Wikipedia:Musculus_uvulae +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0003682 {source="Wikipedia"} ! palatal muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: has_muscle_insertion UBERON:0001734 ! palatine uvula +relationship: has_muscle_insertion UBERON:0001734 ! palatine uvula +relationship: has_muscle_insertion UBERON:0014780 ! palatine aponeurosis +relationship: has_muscle_origin UBERON:0003216 ! hard palate +relationship: innervated_by UBERON:0000929 ! pharyngeal branch of vagus nerve property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray169.png xsd:anyURI property_value: UBPROP:0000001 "The muscle of the uvuli is an integral part of the soft palate and is innervated by Cranial Nerve X .[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} @@ -287892,6 +402543,9 @@ def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch max xref: EHDAA2:0000044 is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: develops_from UBERON:0002342 ! neural crest +intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme [Term] id: UBERON:0010254 @@ -288011,6 +402665,10 @@ synonym: "umbilical vessel" EXACT [] xref: EMAPA:36493 xref: SCTID:408728001 is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: overlaps UBERON:0002331 ! umbilical cord +relationship: located_in UBERON:0003422 ! mesenchyme of umbilical cord +relationship: overlaps UBERON:0002331 ! umbilical cord [Term] id: UBERON:0010262 @@ -288058,8 +402716,19 @@ xref: FMA:59494 xref: SCTID:119534005 is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0005913 ! zone of bone organ +intersection_of: part_of UBERON:0001685 ! hyoid bone relationship: part_of UBERON:0001685 ! hyoid bone +[Term] +id: UBERON:0010276 +name: space in vertebral column +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0001130 ! vertebral column +relationship: part_of UBERON:0001130 ! vertebral column + [Term] id: UBERON:0010277 name: mesocardium @@ -288203,6 +402872,7 @@ synonym: "stratified squamous nonkeratinizing epithelium" EXACT [http://orcid.or xref: FMA:45569 xref: Wikipedia:Stratified_squamous_epithelium#Nonkeratinized is_a: UBERON:0006915 {source="FMA"} ! stratified squamous epithelium +disjoint_from: UBERON:0012329 ! keratinized stratified squamous epithelium [Term] id: UBERON:0010305 @@ -288217,7 +402887,10 @@ xref: SCTID:29445007 xref: Wikipedia:Conjunctiva#Gross_anatomy is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000064 ! organ part +intersection_of: subdivision_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva +relationship: subdivision_of UBERON:0001811 ! conjunctiva [Term] id: UBERON:0010306 @@ -288248,6 +402921,16 @@ xref: SCTID:276831007 is_a: UBERON:0010305 {source="FMA"} ! subdivision of conjunctiva property_value: UBPROP:0000009 "It is loose and flexible, allowing the free movement of the lids and eyeball" xsd:string +[Term] +id: UBERON:0010309 +name: palpebral bone +is_a: UBERON:0003462 ! facial bone +is_a: UBERON:0010321 ! skeletal element of eye region +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0001712 ! upper eyelid +relationship: only_in_taxon NCBITaxon:8457 ! Sauropsida +relationship: part_of UBERON:0001712 ! upper eyelid + [Term] id: UBERON:0010312 name: immature eye @@ -288365,8 +403048,21 @@ namespace: uberon def: "Mesenchyme that is part of a developing eyelid." [OBOL:automatic] xref: EMAPA:32759 is_a: UBERON:0003314 ! eye mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid +[Term] +id: UBERON:0010332 +name: epithelium of handplate +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0006875 ! embryonic handplate +relationship: develops_from UBERON:0003372 ! pectoral appendage bud ectoderm +relationship: part_of UBERON:0006875 ! embryonic handplate + [Term] id: UBERON:0010333 name: extraembryonic membrane mesenchyme @@ -288375,6 +403071,8 @@ def: "Mesenchyme that is part of a extraembryonic membrane." [OBOL:automatic] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0005631 ! extraembryonic membrane relationship: develops_from UBERON:0005728 {source="EHDAA2-abduced"} ! extraembryonic mesoderm relationship: part_of UBERON:0005631 ! extraembryonic membrane @@ -288386,8 +403084,21 @@ def: "Mesenchyme that develops_from a neural crest and is part of a maxillary pr xref: EHDAA2:0004601 is_a: UBERON:0009526 ! maxillary process mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: develops_from UBERON:0002342 ! neural crest +intersection_of: part_of UBERON:0009526 ! maxillary process mesenchyme relationship: develops_from UBERON:0010253 {source="EHDAA2"} ! 1st arch maxillary mesenchyme from neural crest +[Term] +id: UBERON:0010335 +name: maxillary process mesenchyme from head mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0009526 ! maxillary process mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm +intersection_of: part_of UBERON:0009526 ! maxillary process mesenchyme +relationship: develops_from UBERON:0010338 ! 1st arch maxillary mesenchyme from head mesenchyme + [Term] id: UBERON:0010336 name: mandibular process mesenchyme from neural crest @@ -288414,6 +403125,15 @@ intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm intersection_of: part_of UBERON:0006905 ! mandibular process mesenchyme relationship: develops_from UBERON:0010339 {source="EHDAA2"} ! 1st arch mandibular mesenchyme from head mesenchyme +[Term] +id: UBERON:0010338 +name: 1st arch maxillary mesenchyme from head mesenchyme +is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme +is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: develops_from UBERON:0006904 ! head mesenchyme from mesoderm +intersection_of: part_of UBERON:0010045 ! 1st arch maxillary mesenchyme + [Term] id: UBERON:0010339 name: 1st arch mandibular mesenchyme from head mesenchyme @@ -288529,6 +403249,9 @@ def: "An otic capsule endochondral element that is composed primarily of a pre-c synonym: "otic capsule anlage" EXACT [] xref: EHDAA2:0000833 is_a: UBERON:0004637 ! otic capsule +intersection_of: UBERON:0004637 ! otic capsule +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010354 @@ -288619,10 +403342,9 @@ xref: http://en.wikipedia.org/wiki/Endoskeleton xref: VSAO:0000037 xref: Wikipedia:Endoskeleton xref: XAO:0004026 -is_a: BFO:0000040 ! material entity is_a: UBERON:0010912 {source="VSAO"} ! subdivision of skeleton relationship: composed_primarily_of UBERON:0010522 ! replacement element -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: UBPROP:0000001 "An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t" xsd:string {source="Wikipedia:Endoskeleton"} property_value: UBPROP:0000001 "An endoskeleton is an internal support structure of an animal, composed of mineralized tissue. Endoskeleton develops within the skin or in the deeper body tissues. The vertebrate is basically an endoskeleton made up of two types of tissues (bone and cartilage). During early embryonic development the endoskeleton is composed of notochord and cartilage. The notochord in most vertebrates is replaced by vertebral column and cartilage is replaced by bone in most adults. In three phyla and one subclass of animals, endoskeletons of various complexity are found: Chordata, Echinodermata, Porifera, and Coleoidea. An endoskeleton may function purely for support (as in the case of sponges), but often serves as an attachment site for muscle and a mechanism for transmitting muscular forces. A true endoskeleton is derived from mesodermal tissue. Such a skeleton is present in echinoderms and chordates. The poriferan 'skeleton' consists of microscopic calcareous or siliceous spicules or a spongin network. The Coleoidae do not have a true endoskeleton in the evolutionary sense; here, a mollusk exoskeleton evolved into several sorts of internal structure, the 'cuttlebone' of cuttlefish being the best-known version. Yet they do have cartilaginous tissue in their body, even if it is not mineralized, especially in the head, where it forms a primitive cranium. The endoskeleton gives shape,support and protection to the body and provides a mean of locomotion.[Wikipedia:Endoskeleton]t" xsd:string {source="http://en.wikipedia.org/wiki/Endoskeleton"} @@ -288651,7 +403373,7 @@ synonym: "exoskeleton" BROAD INCONSISTENT [VSAO:curator] xref: VSAO:0000035 xref: XAO:0004025 is_a: UBERON:0010912 {source="VSAO"} ! subdivision of skeleton -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0010365 @@ -288677,7 +403399,12 @@ xref: XAO:0004046 xref: ZFA:0005623 is_a: UBERON:0004755 ! skeletal tissue is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0004755 ! skeletal tissue +intersection_of: develops_from UBERON:0001763 ! odontogenic papilla +intersection_of: part_of UBERON:0010364 ! dermal skeleton +relationship: contributes_to_morphology_of UBERON:0001091 ! calcareous tooth relationship: develops_from UBERON:0001763 ! odontogenic papilla +relationship: part_of UBERON:0001091 {gci_relation="part_of", gci_filler="NCBITaxon:32524"} ! calcareous tooth relationship: part_of UBERON:0010364 ! dermal skeleton property_value: UBPROP:0000008 "in many vertebrates, odontoid tissue is not restricted to the teeth" xsd:string property_value: UBPROP:0000012 "Classified as a portion of organism substance in FMA" xsd:string {external_ontology="FMA"} @@ -288693,6 +403420,8 @@ synonym: "set of conjunctival veins" EXACT [FMA:70887] synonym: "venae conjunctivales" EXACT LATIN [FMA:TA] xref: FMA:70887 is_a: UBERON:0002203 ! vasculature of eye +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0001811 ! conjunctiva [Term] @@ -288706,6 +403435,8 @@ xref: SCTID:149885003 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001811 ! conjunctiva relationship: part_of UBERON:0010366 ! conjunctival vasculature [Term] @@ -288718,6 +403449,9 @@ xref: FMA:75739 xref: NCIT:C33428 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009911 ! lobule +intersection_of: UBERON:0009911 ! lobule +intersection_of: part_of UBERON:0002048 ! lung +relationship: has_part UBERON:0002187 ! terminal bronchiole relationship: part_of UBERON:0002048 ! lung [Term] @@ -288742,6 +403476,9 @@ xref: EHDAA2:0001384 xref: FMA:79793 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0009708 ! dorsal pancreas +relationship: has_potential_to_develop_into UBERON:0009708 ! dorsal pancreas relationship: part_of UBERON:0003921 {source="EHDAA2"} ! pancreas primordium property_value: editor_note "consider merging with dorsal pancreatic bud. Starts at CS12 in human (EHDAA2, embryology.ch 'bud anlagen')" xsd:string @@ -288754,6 +403491,9 @@ xref: EHDAA2:0001387 xref: FMA:79794 is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0009709 ! ventral pancreas +relationship: has_potential_to_develop_into UBERON:0009709 ! ventral pancreas relationship: part_of UBERON:0003921 {source="EHDAA2"} ! pancreas primordium property_value: UBPROP:0000008 "Starts at CS14 in human (EHDAA2) or CS13-14 (embryology.ch 'bud anlagen')" xsd:string @@ -288788,6 +403528,19 @@ intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from UBERON:0004873 ! splanchnopleure relationship: part_of UBERON:0009142 {source="EHDAA2"} ! entire embryonic mesenchyme +[Term] +id: UBERON:0010379 +name: superior tarsal muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0003386 ! smooth muscle of eye +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0004773 ! superior eyelid tarsus +relationship: continuous_with UBERON:0001604 ! levator palpebrae superioris +relationship: has_muscle_origin UBERON:0001604 ! levator palpebrae superioris +relationship: innervated_by UBERON:0000013 ! sympathetic nervous system +relationship: part_of UBERON:0004773 ! superior eyelid tarsus + [Term] id: UBERON:0010380 name: enteric nerve @@ -288799,6 +403552,18 @@ xref: MA:0001145 is_a: UBERON:0001021 ! nerve relationship: part_of UBERON:0002005 ! enteric nervous system +[Term] +id: UBERON:0010384 +name: lumen of laryngopharynx +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001051 ! hypopharynx +relationship: luminal_space_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001731 ! cavity of pharynx + [Term] id: UBERON:0010386 name: Peyer's patch follicle @@ -288807,7 +403572,6 @@ def: "A lymphoid follicle that is part of a Peyer's patch." [OBOL:automatic] subset: pheno_slim synonym: "Peyer's patch follicle" EXACT [MA:0000732] xref: MA:0000732 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000444 ! lymphoid follicle relationship: part_of UBERON:0001211 ! Peyer's patch @@ -288838,6 +403602,7 @@ xref: EMAPA:37495 {source="MA:th"} xref: MA:0001400 xref: MA:0001414 is_a: UBERON:0005913 ! zone of bone organ +relationship: connected_to UBERON:0002412 ! vertebra relationship: part_of UBERON:0002228 {source="MA"} ! rib [Term] @@ -288937,6 +403702,7 @@ id: UBERON:0010395 name: lymph node primary follicle namespace: uberon def: "An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex." [https://github.com/obophenotype/uberon/issues/6, MP:0002345] +subset: human_reference_atlas subset: pheno_slim synonym: "primary follicle of lymph node" EXACT [] xref: EMAPA:35530 @@ -288944,32 +403710,36 @@ xref: FMA:312350 xref: MA:0000743 is_a: UBERON:0010422 ! primary nodular lymphoid tissue is_a: UBERON:0010748 ! lymph node follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010396 name: afferent lymphatic vessel namespace: uberon def: "Lymphatic vessel that enters the lymph node. The afferent lymph vessels enter at all parts of the periphery of the lymph node, and after branching and forming a dense plexus in the substance of the capsule, open into the lymph sinuses of the cortical part. In doing this they lose all their coats except their endothelial lining, which is continuous with a layer of similar cells lining the lymph paths." [MP:MP] +subset: human_reference_atlas subset: pheno_slim synonym: "vasa afferentia lymphoglandula" EXACT [Wikipedia:Afferent_lymphatic_vessels] synonym: "vasa afferentia lymphoglandulae" EXACT [Wikipedia:Afferent_lymphatic_vessels] xref: MA:0000748 xref: Wikipedia:File\:Illu_lymph_node_structure.png -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001473 ! lymphatic vessel relationship: part_of UBERON:0000029 ! lymph node +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010397 name: efferent lymphatic vessel namespace: uberon def: "Lymphatic vessel that exits the lymph node. The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes either to veins or greater nodes. Efferent lymphatic vessels are also found in the thymus and spleen. This is in contrast to afferent lymphatic vessels, which are found only in lymph nodes." [MP:MP] +subset: human_reference_atlas subset: pheno_slim synonym: "efferent lymphatic vessel" RELATED [Wikipedia:Efferent_lymph_vessel] synonym: "efferent lymphatic vessels" RELATED [Wikipedia:Efferent_lymph_vessel] xref: MA:0000749 xref: Wikipedia:Efferent_lymph_vessel is_a: UBERON:0001473 ! lymphatic vessel +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010398 @@ -288991,6 +403761,7 @@ id: UBERON:0010399 name: spleen trabecular artery namespace: uberon def: "One of the branches of the splenic artery[MP]." [MP:0002354, Wikipedia:Trabecular_arteries] +subset: human_reference_atlas subset: pheno_slim synonym: "trabecular artery" RELATED [] xref: MA:0000759 @@ -288999,7 +403770,12 @@ xref: UMLS:C1710159 {source="ncithesaurus:Splenic_Trabecular_Artery"} xref: Wikipedia:Trabecular_arteries is_a: UBERON:0003497 ! abdomen blood vessel is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: part_of UBERON:0001265 ! trabecula of spleen +relationship: branching_part_of UBERON:0001194 ! splenic artery +relationship: contributes_to_morphology_of UBERON:0002106 ! spleen relationship: part_of UBERON:0001265 ! trabecula of spleen +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia]" xsd:string {ontology="Wikipedia", source="Wikipedia:Trabecular_arteries"} [Term] @@ -289007,6 +403783,7 @@ id: UBERON:0010400 name: spleen trabecular vein namespace: uberon def: "One of the veins that feed the splenic vein." [MP:0002228, Wikipedia:Trabecular_veins] +subset: human_reference_atlas subset: pheno_slim synonym: "trabecular vein" RELATED [Wikipedia:Trabecular_veins] xref: MA:0000760 @@ -289014,7 +403791,11 @@ xref: NCIT:C49779 xref: UMLS:C1710160 {source="ncithesaurus:Splenic_Trabecular_Vein"} xref: Wikipedia:Trabecular_veins is_a: UBERON:0013126 ! vein of abdomen +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001265 ! trabecula of spleen +relationship: contributes_to_morphology_of UBERON:0002106 ! spleen relationship: part_of UBERON:0001265 ! trabecula of spleen +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia]" xsd:string {ontology="Wikipedia", source="Wikipedia:Trabecular_veins"} [Term] @@ -289022,6 +403803,7 @@ id: UBERON:0010401 name: spleen central arteriole namespace: uberon def: "A blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein." [MP:MP] +subset: human_reference_atlas subset: pheno_slim synonym: "central arteriole" BROAD [] synonym: "follicular arteriole" EXACT [MP:0002361] @@ -289030,6 +403812,7 @@ synonym: "splenic central arteriole" EXACT [MP:0002361] xref: MA:0000763 is_a: UBERON:0022292 ! splenic arteriole relationship: part_of UBERON:0001959 ! white pulp of spleen +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010402 @@ -289106,6 +403889,7 @@ id: UBERON:0010408 name: ocular angle artery namespace: uberon def: "The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein." [MP:MP] +subset: human_reference_atlas synonym: "angular artery" EXACT [FMA:49583] xref: EMAPA:37673 {source="MA:th"} xref: FMA:49583 @@ -289115,6 +403899,7 @@ xref: SCTID:145238006 xref: UMLS:C0226116 {source="ncithesaurus:Angular_Artery"} is_a: UBERON:0004573 ! systemic artery is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010409 @@ -289143,6 +403928,8 @@ synonym: "inguinal fat depot" EXACT [] xref: MA:0002548 is_a: UBERON:0003838 ! abdominal segment connective tissue is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0008337 ! inguinal part of abdomen relationship: part_of UBERON:0008337 ! inguinal part of abdomen [Term] @@ -289155,6 +403942,9 @@ synonym: "retroperitoneal fat depot" EXACT [] xref: MA:0002549 is_a: UBERON:0003427 ! abdominal fat pad is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0002358 ! peritoneum +relationship: located_in UBERON:0003693 ! retroperitoneal space relationship: part_of UBERON:0002358 ! peritoneum [Term] @@ -289169,6 +403959,8 @@ xref: MA:0002550 is_a: UBERON:0003916 ! fat pad is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001301 ! epididymis relationship: part_of UBERON:0001301 ! epididymis [Term] @@ -289184,6 +403976,8 @@ xref: BTO:0005628 xref: MA:0002953 is_a: UBERON:0014394 ! uterine fat pad is_a: UBERON:0015143 ! mesenteric fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0010391 ! parametrium relationship: part_of UBERON:0010391 ! parametrium [Term] @@ -289195,6 +403989,8 @@ subset: pheno_slim synonym: "omental fat depot" EXACT [MP:0010044] xref: MA:0002956 is_a: UBERON:0010411 ! retroperitoneal fat pad +intersection_of: UBERON:0003427 ! abdominal fat pad +intersection_of: part_of UBERON:0003688 ! omentum relationship: part_of UBERON:0003688 ! omentum [Term] @@ -289217,9 +404013,9 @@ synonym: "whisker sensory area" RELATED [NeuroNames:2703] xref: BAMS:SS-bfd xref: BAMS:SSp-bfd xref: EMAPA:35163 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2703 xref: MA:0002712 xref: MBA:329 +xref: neuronames:2703 xref: NLX:81 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0035014 {source="cjm"} ! functional part of brain @@ -289255,6 +404051,8 @@ xref: EMAPA:37663 {source="MA:th"} xref: MA:0002852 xref: SCTID:326870003 is_a: UBERON:0010393 ! T cell domain +intersection_of: UBERON:0010393 ! T cell domain +intersection_of: part_of UBERON:0000029 ! lymph node relationship: part_of UBERON:0002006 {source="MP"} ! cortex of lymph node [Term] @@ -289292,6 +404090,7 @@ id: UBERON:0010420 name: lymph node germinal center mantle zone namespace: uberon def: "A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it." [http://orcid.org/0000-0003-4183-8865/, https://github.com/obophenotype/uberon/issues/7, https://orcid.org/0000-0001-9990-8331, MP:MP, PMID:25656706] +subset: human_reference_atlas subset: pheno_slim synonym: "germinal center mantle zone" BROAD [] synonym: "lymph node B cell corona" EXACT [CL:tm] @@ -289306,12 +404105,14 @@ xref: EMAPA:37661 {source="MA:th"} xref: MA:0002990 is_a: UBERON:0010755 ! secondary follicle corona relationship: part_of UBERON:0010753 {source="MA"} ! lymph node secondary follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010421 name: spleen B cell corona namespace: uberon def: "The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes." [CL:tm, https://github.com/obophenotype/uberon/issues/6, PMID:17495967] +subset: human_reference_atlas subset: pheno_slim synonym: "B cell domain of the spleen" BROAD [MP:0002360] synonym: "B lymphocyte domain of the spleen" BROAD [] @@ -289327,6 +404128,7 @@ xref: EMAPA:37962 {source="MA:th"} is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010755 ! secondary follicle corona relationship: part_of UBERON:0004042 {source="CL:tm"} ! spleen secondary B follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010422 @@ -289340,6 +404142,12 @@ xref: FMA:55223 is_a: UBERON:0000444 {source="FMA"} ! lymphoid follicle property_value: UBPROP:0000015 "The cortex of lymph nodes, the white pulp of spleen, and mucosa associated lymphoid tissue all have these primary follicles" xsd:string +[Term] +id: UBERON:0010424 +name: distal segment of rib +is_a: UBERON:0005913 ! zone of bone organ +relationship: part_of UBERON:0002228 ! rib + [Term] id: UBERON:0010425 name: internal naris @@ -289353,10 +404161,27 @@ synonym: "internal nares" RELATED PLURAL [] synonym: "internal nostril" RELATED [] xref: NCIT:C32856 is_a: UBERON:0000003 ! naris +intersection_of: UBERON:0000003 ! naris +intersection_of: connects UBERON:0001707 ! nasal cavity +intersection_of: connects UBERON:0006562 ! pharynx +relationship: connects UBERON:0006562 ! pharynx +relationship: only_in_taxon NCBITaxon:8287 ! Sarcopterygii property_value: UBPROP:0000007 "choanal" xsd:string property_value: UBPROP:0000008 "In humans the only internal naris is the posterior nasal aperture, which connects to the nasopharynx" xsd:string property_value: UBPROP:0000202 FMA:76585 +[Term] +id: UBERON:0010426 +name: oropharyngeal choana +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010425 ! internal naris +intersection_of: UBERON:0010425 ! internal naris +intersection_of: connects UBERON:0001707 ! nasal cavity +intersection_of: connects UBERON:0001729 ! oropharynx +intersection_of: part_of UBERON:0001716 ! secondary palate +relationship: connects UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001716 ! secondary palate + [Term] id: UBERON:0010427 name: ciliary processes @@ -289385,8 +404210,8 @@ property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/b2/G id: UBERON:0010428 name: flat bone namespace: uberon -def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [http://en.wikipedia.org/wiki/Flat_bone] def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [Wikipedia:Flat_bone] +def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [http://en.wikipedia.org/wiki/Flat_bone] comment: Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs synonym: "os planum" RELATED LATIN [http://en.wikipedia.org/wiki/Flat_bone] synonym: "os planum" RELATED LATIN [Wikipedia:Flat_bone] @@ -289539,6 +404364,7 @@ namespace: uberon def: "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." [http://orcid.org/0000-0002-6601-2165, MESH:A07.231.432, ZFA:0005251] synonym: "microcirculatory vessels" RELATED PLURAL [TAO:0005251] xref: MESH:A07.231.432 +xref: MESH:D055806 xref: TAO:0005251 xref: ZFA:0005251 is_a: UBERON:0000055 ! vessel @@ -289565,6 +404391,16 @@ xref: FMA:24028 is_a: UBERON:0010527 {source="FMA"} ! cavity of bone organ relationship: part_of UBERON:0008193 ! pneumatized bone +[Term] +id: UBERON:0010531 +name: metanephros induced blastemal cells +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0005423 ! developing anatomical structure +relationship: developmentally_induced_by UBERON:0000084 ! ureteric bud +relationship: develops_from UBERON:0003220 ! metanephric mesenchyme +relationship: has_part CL:0000354 ! blastemal cell +relationship: part_of UBERON:0009871 ! nephrogenic zone + [Term] id: UBERON:0010532 name: primitive nephron @@ -289578,15 +404414,55 @@ is_a: UBERON:0003914 {source="EHDAA2-inferred"} ! epithelial tube is_a: UBERON:0004819 ! kidney epithelium is_a: UBERON:0006555 ! excretory tube relationship: develops_from UBERON:0004209 {source="EHDAA2"} ! renal vesicle +relationship: has_potential_to_develop_into UBERON:0001285 ! nephron +relationship: located_in UBERON:0003918 ! kidney mesenchyme property_value: UBPROP:0000012 "EHDAA2 treats this as already having a tubular structure, but in the ZFA representation this is a cluster of cells" xsd:string {external_ontology="EHDAA2"} +[Term] +id: UBERON:0010533 +name: metanephros cortex +is_a: UBERON:0001225 ! cortex of kidney +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001225 ! cortex of kidney +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: develops_from UBERON:0005113 ! metanephric cortex mesenchyme +relationship: part_of UBERON:0000081 ! metanephros + +[Term] +id: UBERON:0010534 +name: primitive mesonephric nephron +is_a: UBERON:0000083 ! mesonephric tubule +is_a: UBERON:0010532 ! primitive nephron +intersection_of: UBERON:0010532 ! primitive nephron +intersection_of: part_of UBERON:0000080 ! mesonephros + +[Term] +id: UBERON:0010535 +name: primitive metanephric nephron +is_a: UBERON:0005106 ! metanephric tubule +is_a: UBERON:0010532 ! primitive nephron +intersection_of: UBERON:0010532 ! primitive nephron +intersection_of: part_of UBERON:0000081 ! metanephros +relationship: part_of UBERON:0005113 ! metanephric cortex mesenchyme + [Term] id: UBERON:0010536 name: nephron progenitor namespace: uberon +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000479 {source="ZFA"} ! tissue +relationship: has_potential_to_develop_into UBERON:0001285 ! nephron relationship: part_of UBERON:0003918 {source="cjm"} ! kidney mesenchyme +[Term] +id: UBERON:0010537 +name: mesonephric nephron progenitor +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010536 ! nephron progenitor +intersection_of: UBERON:0010536 ! nephron progenitor +intersection_of: part_of UBERON:0000080 ! mesonephros +relationship: part_of UBERON:0000080 ! mesonephros + [Term] id: UBERON:0010538 name: paired limb/fin segment @@ -289595,6 +404471,10 @@ def: "An appendage segment that is part of a limb/fin." [OBOL:automatic] subset: homology_grouping synonym: "limb/fin segment" EXACT [] is_a: UBERON:0010758 ! subdivision of organism along appendicular axis +intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis +intersection_of: part_of UBERON:0004708 ! paired limb/fin +disjoint_from: UBERON:0010912 ! subdivision of skeleton +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0004708 ! paired limb/fin [Term] @@ -289607,7 +404487,10 @@ is_a: UBERON:0003328 ! mesenchyme of footplate is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0015050 ! tarsus endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001447 ! tarsal bone relationship: develops_from UBERON:0010695 ! mesenchyme of tarsal region +relationship: has_potential_to_develop_into UBERON:0001447 ! tarsal bone [Term] id: UBERON:0010541 @@ -289619,7 +404502,10 @@ is_a: UBERON:0003328 ! mesenchyme of footplate is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0015050 ! tarsus endochondral element +intersection_of: UBERON:0005863 ! cartilaginous condensation +intersection_of: has_potential_to_develop_into UBERON:0001447 ! tarsal bone relationship: develops_from UBERON:0010540 {source="EHDAA2"} ! tarsus pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001447 ! tarsal bone [Term] id: UBERON:0010543 @@ -289638,10 +404524,16 @@ synonym: "skeletal parts of acropodium" RELATED [] synonym: "skeleton of digits" RELATED [] xref: FMA:231315 xref: VSAO:0005028 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0012354 ! acropodium region +relationship: has_part UBERON:0015023 ! phalanx endochondral element relationship: part_of UBERON:0012150 {source="PHENOSCAPE:ni"} ! skeleton of digitopodium relationship: part_of UBERON:0012354 ! acropodium region +relationship: proximally_connected_to UBERON:0010546 ! metapodial skeleton +relationship: skeleton_of UBERON:0012354 ! acropodium region [Term] id: UBERON:0010544 @@ -289666,14 +404558,18 @@ synonym: "skeleton of metacarpus" EXACT [] xref: AAO:0000946 xref: EMAPA:36158 xref: FMA:71336 -xref: MESH:A02.835.232.087.535 +xref: MESH:D050279 xref: VSAO:0005026 xref: Wikipedia:Metacarpus xref: XAO:0003208 is_a: UBERON:0010546 ! metapodial skeleton is_a: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0004453 ! metacarpus region relationship: develops_from UBERON:0010699 {notes="many to one"} ! manual digit metacarpus cartilage element -property_value: depicted:by Metacarpals:numbered-en.svg xsd:anyURI +relationship: proximally_connected_to UBERON:0009880 ! carpal skeleton +relationship: skeleton_of UBERON:0004453 ! metacarpus region +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg xsd:anyURI property_value: UBPROP:0000001 "Segment of the forearm corresponding to the metacarpus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000946", ontology="AAO", source="AAO:LAP"} [Term] @@ -289702,7 +404598,11 @@ xref: Wikipedia:Metatarsus xref: XAO:0003212 is_a: UBERON:0010546 ! metapodial skeleton is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0000983 ! metatarsus region relationship: develops_from UBERON:0010697 {notes="many to one"} ! pedal digit metatarsal cartilage element +relationship: proximally_connected_to UBERON:0009879 ! tarsal skeleton +relationship: skeleton_of UBERON:0000983 ! metatarsus region property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png xsd:anyURI property_value: UBPROP:0000001 "Segment of the leg corresponding to the metatarsus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000221", ontology="AAO", source="AAO:LAP"} @@ -289718,10 +404618,16 @@ synonym: "metapodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeletal parts of metapodium" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "skeleton of metapodium" EXACT [] xref: VSAO:0005025 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0009877 ! metapodium region +relationship: distally_connected_to UBERON:0010543 ! acropodial skeleton relationship: part_of UBERON:0009877 ! metapodium region relationship: part_of UBERON:0012150 {source="PHENOSCAPE:ni"} ! skeleton of digitopodium +relationship: proximally_connected_to UBERON:0009878 ! mesopodial skeleton +relationship: skeleton_of UBERON:0009877 ! metapodium region property_value: UBPROP:0000001 "Endochondral bone complex located between the mesopodium and the acropodium and consisting of the metacarpals or metatarsals.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005025", ontology="VSAO", source="VSAO:NI"} property_value: UBPROP:0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005025", ontology="VSAO"} property_value: UBPROP:0000002 "relationship type change: subclass skeletal subdivision (VSAO:0000042) CHANGED TO: distally_connected_to subdivision of skeleton (UBERON:0010912)[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0005025", ontology="VSAO"} @@ -289739,6 +404645,8 @@ xref: EHDAA2:0002040 xref: EMAPA:17725 is_a: UBERON:0010687 ! pedal digit metatarsal pre-cartilage condensation is_a: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010548 @@ -289795,6 +404703,8 @@ xref: EHDAA2:0002060 xref: EMAPA:17733 is_a: UBERON:0010687 ! pedal digit metatarsal pre-cartilage condensation is_a: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010557 @@ -289808,6 +404718,8 @@ synonym: "toe 1 metatarsal cartilage condensation" EXACT [] xref: EMAPA:18106 is_a: UBERON:0010697 ! pedal digit metatarsal cartilage element is_a: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: UBERON:0015037 ! pedal digit 1 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010547 ! pedal digit 1 metatarsal pre-cartilage condensation [Term] @@ -289864,8 +404776,26 @@ synonym: "toe 5 metatarsal cartilage element" EXACT [] xref: EMAPA:18126 is_a: UBERON:0010697 ! pedal digit metatarsal cartilage element is_a: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: UBERON:0015041 ! pedal digit 5 metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010551 ! pedal digit 5 metatarsal pre-cartilage condensation +[Term] +id: UBERON:0010562 +name: pedal digit 1 mesenchyme +is_a: UBERON:0005255 ! pedal digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003631 ! pedal digit 1 +relationship: part_of UBERON:0003631 ! pedal digit 1 + +[Term] +id: UBERON:0010564 +name: manual digit 1 mesenchyme +is_a: UBERON:0005257 ! manual digit mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0001463 ! manual digit 1 +relationship: part_of UBERON:0001463 ! manual digit 1 + [Term] id: UBERON:0010565 name: manual digit 1 metacarpus pre-cartilage condensation @@ -289880,6 +404810,8 @@ xref: EHDAA2:0000515 xref: EMAPA:17714 is_a: UBERON:0010698 ! manual digit metacarpus pre-cartilage condensation is_a: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010566 @@ -289940,6 +404872,8 @@ xref: EHDAA2:0000539 xref: EMAPA:17722 is_a: UBERON:0010698 ! manual digit metacarpus pre-cartilage condensation is_a: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010570 @@ -289955,6 +404889,8 @@ xref: EHDAA2:0000514 xref: EMAPA:18065 is_a: UBERON:0010699 ! manual digit metacarpus cartilage element is_a: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: UBERON:0015043 ! manual digit 1 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010565 ! manual digit 1 metacarpus pre-cartilage condensation [Term] @@ -290019,6 +404955,8 @@ xref: EHDAA2:0000538 xref: EMAPA:18085 is_a: UBERON:0010699 ! manual digit metacarpus cartilage element is_a: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: UBERON:0015047 ! manual digit 5 metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010569 ! manual digit 5 metacarpus pre-cartilage condensation [Term] @@ -290033,6 +404971,8 @@ xref: EHDAA2:0000516 xref: EMAPA:17715 is_a: UBERON:0010586 ! manual digit phalanx pre-cartilage condensation is_a: UBERON:0015025 ! manual digit 1 phalanx endochondral element +intersection_of: UBERON:0015025 ! manual digit 1 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010576 @@ -290085,6 +405025,8 @@ xref: EHDAA2:0000540 xref: EMAPA:17723 is_a: UBERON:0010586 ! manual digit phalanx pre-cartilage condensation is_a: UBERON:0015029 ! manual digit 5 phalanx endochondral element +intersection_of: UBERON:0015029 ! manual digit 5 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010580 @@ -290098,6 +405040,8 @@ xref: EHDAA2:0002041 xref: EMAPA:17726 is_a: UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation is_a: UBERON:0015031 ! pedal digit 1 phalanx endochondral element +intersection_of: UBERON:0015031 ! pedal digit 1 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010581 @@ -290150,6 +405094,8 @@ xref: EHDAA2:0002061 xref: EMAPA:17734 is_a: UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation is_a: UBERON:0015035 ! pedal digit 5 phalanx endochondral element +intersection_of: UBERON:0015035 ! pedal digit 5 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010585 @@ -290166,6 +405112,8 @@ xref: VHOG:0000952 is_a: UBERON:0010700 ! phalanx pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010586 @@ -290182,6 +405130,8 @@ xref: VHOG:0000954 is_a: UBERON:0010700 ! phalanx pre-cartilage condensation is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010675 @@ -290194,6 +405144,8 @@ synonym: "manual digit I phalanx cartilage element" EXACT COMPARATIVE_PREFERRED xref: EMAPA:18066 is_a: UBERON:0010686 ! manual digit phalanx cartilage element is_a: UBERON:0015025 ! manual digit 1 phalanx endochondral element +intersection_of: UBERON:0015025 ! manual digit 1 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010575 ! manual digit 1 phalanx pre-cartilage condensation [Term] @@ -290246,6 +405198,8 @@ synonym: "manual digit V phalanx cartilage element" EXACT COMPARATIVE_PREFERRED xref: EMAPA:18086 is_a: UBERON:0010686 ! manual digit phalanx cartilage element is_a: UBERON:0015029 ! manual digit 5 phalanx endochondral element +intersection_of: UBERON:0015029 ! manual digit 5 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010579 ! manual digit 5 phalanx pre-cartilage condensation [Term] @@ -290259,6 +405213,8 @@ synonym: "pedal digit I phalanx cartilage element" EXACT COMPARATIVE_PREFERRED [ xref: EMAPA:18107 is_a: UBERON:0010685 ! pedal digit phalanx cartilage element is_a: UBERON:0015031 ! pedal digit 1 phalanx endochondral element +intersection_of: UBERON:0015031 ! pedal digit 1 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010580 ! pedal digit 1 phalanx pre-cartilage condensation [Term] @@ -290311,6 +405267,8 @@ synonym: "pedal digit V phalanx cartilage element" EXACT COMPARATIVE_PREFERRED [ xref: EMAPA:18127 is_a: UBERON:0010685 ! pedal digit phalanx cartilage element is_a: UBERON:0015035 ! pedal digit 5 phalanx endochondral element +intersection_of: UBERON:0015035 ! pedal digit 5 phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010584 ! pedal digit 5 phalanx pre-cartilage condensation [Term] @@ -290324,6 +405282,8 @@ xref: EMAPA:32948 is_a: UBERON:0010701 ! phalanx cartilage element is_a: UBERON:0015030 ! pedal digit phalanx endochondral element is_a: UBERON:0035129 ! pes cartilage element +intersection_of: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation [Term] @@ -290337,6 +405297,8 @@ xref: EMAPA:32658 is_a: UBERON:0010701 ! phalanx cartilage element is_a: UBERON:0015024 ! manual digit phalanx endochondral element is_a: UBERON:0035128 ! manus cartilage element +intersection_of: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010586 ! manual digit phalanx pre-cartilage condensation [Term] @@ -290355,6 +405317,8 @@ is_a: UBERON:0003860 ! hindlimb mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010688 @@ -290377,7 +405341,26 @@ xref: FMA:71337 xref: VSAO:0005029 xref: Wikipedia:Phalanges_of_the_hand is_a: UBERON:0010543 ! acropodial skeleton +intersection_of: UBERON:0010543 ! acropodial skeleton +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0012151 {source="PHENOSCAPE:ni"} ! skeleton of manual digitopodium +relationship: proximally_connected_to UBERON:0010544 ! metacarpus skeleton + +[Term] +id: UBERON:0010690 +name: manual digit 1 epithelium +is_a: UBERON:0005227 ! manual digit epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001463 ! manual digit 1 +relationship: part_of UBERON:0001463 ! manual digit 1 + +[Term] +id: UBERON:0010693 +name: pedal digit 1 epithelium +is_a: UBERON:0005226 ! pedal digit epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003631 ! pedal digit 1 +relationship: part_of UBERON:0003631 ! pedal digit 1 [Term] id: UBERON:0010695 @@ -290386,6 +405369,8 @@ namespace: uberon def: "Mesenchyme of the carpal region that contributes to the tarsal skeleton." [https://orcid.org/0000-0002-6601-2165] xref: EMAPA:18502 is_a: UBERON:0003860 ! hindlimb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0004454 ! tarsal region relationship: part_of UBERON:0004454 ! tarsal region [Term] @@ -290408,7 +405393,10 @@ xref: FMA:78512 xref: VSAO:0005030 xref: Wikipedia:Phalanges_of_the_foot is_a: UBERON:0010543 ! acropodial skeleton +intersection_of: UBERON:0010543 ! acropodial skeleton +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0012152 {source="PHENOSCAPE:ni"} ! skeleton of pedal digitopodium +relationship: proximally_connected_to UBERON:0010545 ! metatarsus skeleton [Term] id: UBERON:0010697 @@ -290420,6 +405408,8 @@ synonym: "metatarsal cartilage condensation" RELATED [EMAPA:32951] xref: EMAPA:32951 is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element is_a: UBERON:0035129 ! pes cartilage element +intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010687 ! pedal digit metatarsal pre-cartilage condensation property_value: editor_note "EMAPA represents the specific child classes as being part of the digit mesenchyme - we follow this although for the fully formed structure we represent the metatarsals as adjoining rather than being part of the digit skeleton" xsd:string @@ -290436,6 +405426,8 @@ xref: EMAPA:32850 xref: VHOG:0000953 is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010699 @@ -290450,6 +405442,8 @@ synonym: "metacarpus cartilage element" EXACT [] xref: EMAPA:32849 is_a: UBERON:0015042 ! manual digit metacarpus endochondral element is_a: UBERON:0035128 ! manus cartilage element +intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010698 ! manual digit metacarpus pre-cartilage condensation [Term] @@ -290459,6 +405453,8 @@ namespace: uberon xref: EMAPA:32720 is_a: UBERON:0010882 ! limb bone pre-cartilage condensation is_a: UBERON:0015023 ! phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: part_of UBERON:0010702 {source="EMAPA"} ! digit mesenchyme [Term] @@ -290469,6 +405465,8 @@ synonym: "phalanx cartilage condensation" EXACT [EMAPA:32721] xref: EMAPA:32721 is_a: UBERON:0015023 ! phalanx endochondral element is_a: UBERON:0015064 ! autopod cartilage +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010700 ! phalanx pre-cartilage condensation [Term] @@ -290481,6 +405479,8 @@ xref: EMAPA:32719 xref: NCIT:C34141 xref: UMLS:C1511959 is_a: UBERON:0009749 ! limb mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002544 ! digit relationship: part_of UBERON:0002544 ! digit [Term] @@ -290505,8 +405505,11 @@ xref: AAO:0000200 xref: FMA:71199 xref: VSAO:0005011 is_a: UBERON:0011584 ! zeugopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002386 ! forelimb zeugopod relationship: part_of UBERON:0001440 ! forelimb skeleton relationship: part_of UBERON:0002386 ! forelimb zeugopod +relationship: skeleton_of UBERON:0002386 ! forelimb zeugopod property_value: editor_note "adding proxinally_connected_to humerus causes inconsistencies - requires investigation" xsd:string property_value: UBPROP:0000001 "Segment of the forearm corresponding to the radius and ulna.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000200", ontology="AAO", source="AAO:LAP"} @@ -290526,7 +405529,10 @@ xref: FMA:7182 xref: VSAO:0000214 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0015212 ! lateral structure +relationship: dc-contributor https://orcid.org/0000-0001-9114-8737 +relationship: functionally_related_to GO:0040011 ! locomotion relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata property_value: editor_note "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" xsd:string property_value: UBPROP:0000001 "Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000214", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070"} property_value: UBPROP:0000005 "It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO]" xsd:string {date_retrieved="2012-09-06", external_class="VSAO:0000214", ontology="VSAO", source="Curator"} @@ -290551,11 +405557,13 @@ xref: FMA:7183 xref: http://www.snomedbrowser.com/Codes/Details/110716002 xref: SCTID:110716002 xref: VSAO:0000213 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: has_part UBERON:0001421 ! pectoral girdle region relationship: has_part UBERON:0001421 ! pectoral girdle region relationship: has_skeleton UBERON:0012475 ! skeleton of pectoral complex +relationship: part_of UBERON:0000153 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! anterior region of body property_value: UBPROP:0000001 "Appendage girdle complex that when present, encompasses the pectoral appendage and half of the pectoral girdle.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000213", ontology="VSAO", source="VSAO:MAH"} property_value: UBPROP:0000012 "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region)" xsd:string {external_ontology="FMA"} @@ -290576,11 +405584,13 @@ xref: FMA:7184 xref: http://www.snomedbrowser.com/Codes/Details/416631005 xref: SCTID:416631005 xref: VSAO:0000215 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: has_part UBERON:0001271 ! pelvic girdle region relationship: has_part UBERON:0001271 ! pelvic girdle region relationship: has_skeleton UBERON:0012476 ! skeleton of pelvic complex +relationship: part_of UBERON:0000154 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! posterior region of body property_value: RO:0002171 UBERON:0010708 property_value: UBPROP:0000001 "Appendage girdle complex that when present, encompasses the pelvic appendage and the pelvic girdle.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000215", ontology="VSAO", source="VSAO:MAH"} property_value: UBPROP:0000012 "note that the FMA uses the terms 'upper limb' and 'lower limb' to refer to the entire appendage complex (free limb plus girdle region). Note the MA class 'hindlimb' may also belong here" xsd:string {external_ontology="FMA"} @@ -290611,6 +405621,8 @@ xref: VHOG:0001126 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015054 ! iliac endochondral element +intersection_of: UBERON:0015054 ! iliac endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006247 {source="EHDAA2"} ! iliac pre-cartilage condensation [Term] @@ -290624,6 +405636,8 @@ xref: EMAPA:26928 is_a: UBERON:0005863 {source="EHDAA2"} ! cartilaginous condensation is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0015055 ! pubic endochondral element +intersection_of: UBERON:0015055 ! pubic endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0006285 {source="EHDAA2"} ! pubic pre-cartilage condensation [Term] @@ -290634,6 +405648,7 @@ def: "The subdivision of the skeleton of either the pectoral or pelvic girdle." synonym: "skeleton of girdle" EXACT [] xref: AAO:0010686 xref: VSAO:0000302 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0007823 ! appendage girdle region @@ -290662,7 +405677,11 @@ synonym: "skeleton cruris" EXACT LATIN [NominaAnatomicaVeterinaria:2005] xref: AAO:0000216 xref: VSAO:0005014 is_a: UBERON:0011584 ! zeugopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0003823 ! hindlimb zeugopod relationship: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: proximally_connected_to UBERON:0000981 ! femur +relationship: skeleton_of UBERON:0003823 ! hindlimb zeugopod property_value: UBPROP:0000001 "Segment of the leg corresponding to the tibia and fibula.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000216", ontology="AAO", source="AAO:LAP"} [Term] @@ -290676,6 +405695,9 @@ is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0009891 ! facial mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest is_a: UBERON:0015059 ! orbitosphenoid endochondral element +intersection_of: UBERON:0015059 ! orbitosphenoid endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation relationship: develops_from UBERON:0006904 {source="EHDAA2"} ! head mesenchyme from mesoderm relationship: part_of UBERON:0009191 {source="EHDAA2"} ! sphenoid bone pre-cartilage condensation @@ -290777,12 +405799,11 @@ synonym: "meninges" EXACT [FMA:231572] xref: EHDAA2:0004661 xref: EMAPA:32660 xref: FMA:231572 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1465 xref: NCIT:C12349 +xref: neuronames:1465 xref: SCTID:362879001 xref: UMLS:C0228116 xref: Wikipedia:Meninges -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection @@ -290804,6 +405825,8 @@ xref: EHDAA2:0001774 xref: EMAPA:17677 is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015010 ! sacral vertebra endochondral element +intersection_of: UBERON:0015010 ! sacral vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010745 @@ -290817,6 +405840,8 @@ xref: EMAPA:18009 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015010 ! sacral vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015010 ! sacral vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010744 {source="EHDAA2"} ! sacral vertebra pre-cartilage condensation [Term] @@ -290863,7 +405888,6 @@ def: "A lymphoid follicle that is part of a lymph node." [OBOL:automatic] synonym: "follicle of lymph node" EXACT [] xref: EMAPA:35527 xref: MA:0000742 -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000444 ! lymphoid follicle relationship: part_of UBERON:0002006 {notes="issues/7", source="MP-def"} ! cortex of lymph node @@ -290898,6 +405922,7 @@ id: UBERON:0010753 name: lymph node secondary follicle namespace: uberon def: "A secondary follicle that is located in a lymph node." [CL:tm] +subset: human_reference_atlas subset: pheno_slim xref: EMAPA:35531 xref: FMA:312352 @@ -290905,6 +405930,7 @@ xref: MA:0000744 is_a: UBERON:0001745 ! secondary nodular lymphoid tissue is_a: UBERON:0010748 {source="MA"} ! lymph node follicle relationship: develops_from UBERON:0010395 ! lymph node primary follicle +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010754 @@ -290924,10 +405950,9 @@ xref: NCIT:C13337 xref: SCTID:64626006 xref: UMLS:C0282491 {source="ncithesaurus:Germinal_Center"} xref: Wikipedia:Germinal_center -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue -property_value: depicted:by Germinal:center.svg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg xsd:anyURI [Term] id: UBERON:0010755 @@ -290942,7 +405967,6 @@ synonym: "peripheral zone of follicle" EXACT [CL:tm] xref: NCIT:C33053 xref: UMLS:C1512987 {source="ncithesaurus:Mantle_Zone"} xref: Wikipedia:Mantle_zone -is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001744 ! lymphoid tissue relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue property_value: editor_note "consider making terminology consistent amongst subclasses - see https://github.com/obophenotype/uberon/issues/7" xsd:string @@ -290975,6 +405999,14 @@ xref: FBbt:00007018 is_a: UBERON:0000475 ! organism subdivision relationship: part_of UBERON:0000026 ! appendage +[Term] +id: UBERON:0010760 +name: supraglenoid tubercle +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005813 ! tubercle +is_a: UBERON:4100000 ! skeletal element projection +relationship: part_of UBERON:0006633 ! coracoid process of scapula + [Term] id: UBERON:0010801 name: calcaneum pre-cartilage condensation @@ -290986,6 +406018,8 @@ is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015014 ! calcaneum endochondral element +intersection_of: UBERON:0015014 ! calcaneum endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0010842 @@ -290998,8 +406032,29 @@ is_a: UBERON:0005863 ! cartilaginous condensation is_a: UBERON:0010695 ! mesenchyme of tarsal region is_a: UBERON:0015014 ! calcaneum endochondral element is_a: UBERON:0035129 ! pes cartilage element +intersection_of: UBERON:0015014 ! calcaneum endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010801 ! calcaneum pre-cartilage condensation +[Term] +id: UBERON:0010843 +name: clavicle cartilage element +is_a: UBERON:0005863 ! cartilaginous condensation +intersection_of: UBERON:0005863 ! cartilaginous condensation +intersection_of: has_potential_to_develop_into UBERON:0001105 ! clavicle bone +relationship: develops_from UBERON:0010844 ! clavicle pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001105 ! clavicle bone +relationship: part_of UBERON:0007831 ! pectoral girdle skeleton + +[Term] +id: UBERON:0010844 +name: clavicle pre-cartilage condensation +is_a: UBERON:0005866 ! pre-cartilage condensation +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001105 ! clavicle bone +relationship: has_potential_to_develop_into UBERON:0001105 ! clavicle bone +relationship: part_of UBERON:0007831 ! pectoral girdle skeleton + [Term] id: UBERON:0010846 name: radius pre-cartilage condensation @@ -291009,7 +406064,10 @@ xref: EHDAA2:0001586 is_a: UBERON:0003327 ! mesenchyme of forearm is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015001 ! radius endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001423 ! radius bone relationship: develops_from UBERON:0006287 {source="EHDAA2"} ! radius-ulna pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001423 ! radius bone property_value: editor_note "still to decide whether this is a distinct pre-cartilage condensation" xsd:string [Term] @@ -291022,7 +406080,21 @@ xref: EHDAA:6226 is_a: UBERON:0003327 ! mesenchyme of forearm is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015003 ! ulna endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001424 ! ulna relationship: develops_from UBERON:0006287 {source="EHDAA2"} ! radius-ulna pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001424 ! ulna + +[Term] +id: UBERON:0010848 +name: radius-ulna cartilage element +is_a: UBERON:0003327 ! mesenchyme of forearm +is_a: UBERON:0005863 ! cartilaginous condensation +is_a: UBERON:0010883 ! forelimb cartilage element +is_a: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: UBERON:0015002 ! radius-ulna endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +relationship: develops_from UBERON:0006287 ! radius-ulna pre-cartilage condensation [Term] id: UBERON:0010849 @@ -291032,6 +406104,8 @@ def: "A cartilaginous condensation that has the potential to develop into a tibi xref: EMAPA:18155 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015004 ! tibia endochondral element +intersection_of: UBERON:0015004 ! tibia endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010850 ! tibia pre-cartilage condensation relationship: part_of UBERON:0005259 {source="EMAPA"} ! lower leg mesenchyme @@ -291044,6 +406118,9 @@ xref: EHDAA2:0002036 is_a: UBERON:0005259 ! lower leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015004 ! tibia endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0000979 ! tibia +relationship: has_potential_to_develop_into UBERON:0000979 ! tibia [Term] id: UBERON:0010851 @@ -291056,6 +406133,8 @@ synonym: "fibulra cartilage condensation" RELATED [EMAPA:18154] xref: EMAPA:18154 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015013 ! fibula endochondral element +intersection_of: UBERON:0015013 ! fibula endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0010852 ! fibula pre-cartilage condensation relationship: part_of UBERON:0005259 {source="EMAPA"} ! lower leg mesenchyme @@ -291071,6 +406150,18 @@ xref: EHDAA:6196 is_a: UBERON:0005259 ! lower leg mesenchyme is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0015013 ! fibula endochondral element +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0001446 ! fibula +relationship: has_potential_to_develop_into UBERON:0001446 ! fibula + +[Term] +id: UBERON:0010854 +name: skin of front of neck +is_a: UBERON:0001417 ! skin of neck +intersection_of: UBERON:0001417 ! skin of neck +intersection_of: part_of UBERON:0000341 ! throat +relationship: part_of UBERON:0000341 ! throat +relationship: part_of UBERON:0011154 ! gular region [Term] id: UBERON:0010881 @@ -291181,6 +406272,8 @@ xref: EMAPA:32634 xref: FMA:9622 xref: MA:0000663 is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0010709 ! pelvic complex relationship: part_of UBERON:0014792 {source="prolog"} ! musculature of pelvic complex property_value: UBPROP:0000001 "Muscles of the pelvic girdle, thigh, leg (crus), and foot (pes).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000218", ontology="AAO", source="AAO:EJS"} @@ -291199,10 +406292,40 @@ xref: EMAPA:32624 xref: FMA:9621 xref: MA:0000615 is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0010708 ! pectoral complex relationship: part_of UBERON:0014793 {source="prolog"} ! musculature of pectoral complex property_value: editor_note "the MA class belongs here, based on its current child classes" xsd:string property_value: UBPROP:0000001 "Muscles of the pectoral girdle, arm, forearm, and hand (brachium, antebrachium, manus respectively).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010687", ontology="AAO", source="AAO:EJS"} +[Term] +id: UBERON:0010893 +name: median external naris +is_a: UBERON:0005928 ! external naris +intersection_of: UBERON:0005928 ! external naris +intersection_of: BSPO:0005001 UBERON:0000033 ! head +relationship: BSPO:0005001 UBERON:0000033 ! head + +[Term] +id: UBERON:0010894 +name: keratinous tooth +is_a: UBERON:0003913 ! tooth-like structure +intersection_of: UBERON:0003913 ! tooth-like structure +intersection_of: composed_primarily_of GO:0045095 ! keratin filament +relationship: composed_primarily_of GO:0045095 ! keratin filament +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata + +[Term] +id: UBERON:0010899 +name: synchronous hermaphroditic organism +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0007197 ! hermaphroditic organism +intersection_of: UBERON:0000468 ! multicellular organism +intersection_of: has_part UBERON:0000473 ! testis +intersection_of: has_part UBERON:0000992 ! ovary +relationship: has_part UBERON:0000473 ! testis +relationship: has_part UBERON:0000992 ! ovary + [Term] id: UBERON:0010900 name: tarsometatarsus cartilage element @@ -291231,7 +406354,11 @@ synonym: "clavicle primordium" EXACT [] xref: EHDAA2:0000254 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001105 ! clavicle bone relationship: develops_from UBERON:0006210 {source="EHDAA2"} ! body-wall mesenchyme +relationship: has_developmental_contribution_from UBERON:0002342 ! neural crest +relationship: has_potential_to_develop_into UBERON:0001105 ! clavicle bone relationship: part_of UBERON:0007831 {source="EHDAA2"} ! pectoral girdle skeleton [Term] @@ -291320,7 +406447,7 @@ xref: MFMO:0000058 xref: SCTID:244749008 xref: Wikipedia:Orbicularis_oris_muscle is_a: UBERON:0001577 ! facial muscle -property_value: depicted:by Orbicularis:oris.jpg xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/b6/Orbicularis_oris.jpg xsd:anyURI property_value: seeAlso https://github.com/obophenotype/uberon/issues/473 xsd:anyURI property_value: UBPROP:0000001 "The orbicularis oris is a superficial facial muscle that attaches to the skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve .[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"} @@ -291332,7 +406459,7 @@ synonym: "belly" BROAD [FMA:9719] synonym: "belly of muscle" EXACT [] synonym: "venter" BROAD LATIN [FMA:TA] xref: FMA:9719 -xref: STID:29823001 +xref: SCTID:29823001 is_a: UBERON:0000064 ! organ part relationship: part_of UBERON:0001630 {source="FMA"} ! muscle organ @@ -291355,6 +406482,29 @@ relationship: part_of UBERON:0000033 ! head property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png xsd:anyURI property_value: UBPROP:0000012 "A zone of muscle in FMA" xsd:string {external_ontology="FMA"} +[Term] +id: UBERON:0010948 +name: cleidooccipital muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0000933 ! pharyngeal muscle +is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0001105 ! clavicle bone +intersection_of: attaches_to UBERON:0001676 ! occipital bone +relationship: attaches_to UBERON:0001105 ! clavicle bone +relationship: attaches_to UBERON:0001676 ! occipital bone + +[Term] +id: UBERON:0010949 +name: sternooccipital muscle +is_a: UBERON:0002377 ! muscle of neck +is_a: UBERON:0003897 ! axial muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: has_muscle_insertion UBERON:0001676 ! occipital bone +intersection_of: has_muscle_origin UBERON:0000975 ! sternum +relationship: has_muscle_insertion UBERON:0001676 ! occipital bone +relationship: has_muscle_origin UBERON:0000975 ! sternum + [Term] id: UBERON:0010952 name: frontalis muscle belly @@ -291375,7 +406525,7 @@ xref: SCTID:368680005 xref: Wikipedia:Frontalis_muscle is_a: UBERON:0010938 ! muscle belly relationship: part_of UBERON:0010946 {source="FMA"} ! occipitofrontalis muscle -property_value: depicted:by Musculus:frontalis.png xsd:anyURI +property_value: depicted:by https://upload.wikimedia.org/wikipedia/commons/b/be/Musculus_frontalis.png xsd:anyURI [Term] id: UBERON:0010953 @@ -291394,6 +406544,15 @@ is_a: UBERON:0008522 {source="FMA"} ! nasal muscle is_a: UBERON:0015212 ! lateral structure property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/b/bb/Nasalis.png xsd:anyURI +[Term] +id: UBERON:0010955 +name: trapezius pre-muscle mass +is_a: UBERON:0005865 ! pre-muscle condensation +is_a: UBERON:0006904 ! head mesenchyme from mesoderm +is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +relationship: develops_from UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +relationship: part_of UBERON:0008713 ! pectoral girdle and thoracic body wall skeletal muscle + [Term] id: UBERON:0010959 name: craniocervical muscle @@ -291462,6 +406621,14 @@ is_a: UBERON:0005865 {source="EHDAA2"} ! pre-muscle condensation relationship: develops_from UBERON:0010963 {source="EHDAA2"} ! trunk and cervical myotome group relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle +[Term] +id: UBERON:0010983 +name: levator scapulae pre-muscle mass +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005865 ! pre-muscle condensation +relationship: develops_from UBERON:0010963 ! trunk and cervical myotome group +relationship: part_of UBERON:0008713 ! pectoral girdle and thoracic body wall skeletal muscle + [Term] id: UBERON:0010984 name: pectoral pre-muscle mass @@ -291489,6 +406656,7 @@ name: articular cartilage of joint namespace: uberon def: "A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints." [BTO:0001572] subset: efo_slim +subset: human_reference_atlas subset: pheno_slim subset: uberon_slim subset: vertebrate_core @@ -291505,12 +406673,13 @@ xref: FMA:12264 xref: GAID:101 xref: galen:ArticularCartilage xref: MA:0000487 -xref: MESH:A02.165.165 +xref: MESH:D002358 xref: NCIT:C32144 xref: SCTID:305026006 xref: UMLS:C0007303 {source="ncithesaurus:Articular_Cartilage"} is_a: UBERON:0001994 {source="MA"} ! hyaline cartilage tissue relationship: part_of UBERON:0002217 {source="Wikipedia"} ! synovial joint +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011004 @@ -291578,6 +406747,64 @@ relationship: part_of UBERON:0003277 ! skeleton of upper jaw relationship: part_of UBERON:0008895 {source="VHOG"} ! splanchnocranium property_value: UBPROP:0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000511", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"} +[Term] +id: UBERON:0011088 +name: ligament of knee joint +is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0001485 ! knee joint +relationship: part_of UBERON:0001485 ! knee joint + +[Term] +id: UBERON:0011090 +name: skeleton of right pelvic girdle +namespace: uberon +def: "A skeleton of pelvic girdle that is part of a right pelvic girdle region." [OBOL:automatic] +xref: FMA:87593 +is_a: UBERON:0007832 ! pelvic girdle skeleton +intersection_of: UBERON:0007832 ! pelvic girdle skeleton +intersection_of: part_of UBERON:0011092 ! right pelvic girdle region +relationship: part_of UBERON:0011092 ! right pelvic girdle region + +[Term] +id: UBERON:0011091 +name: skeleton of left pelvic girdle +namespace: uberon +def: "A skeleton of pelvic girdle that is part of a left pelvic girdle region." [OBOL:automatic] +xref: FMA:87594 +is_a: UBERON:0007832 ! pelvic girdle skeleton +intersection_of: UBERON:0007832 ! pelvic girdle skeleton +intersection_of: part_of UBERON:0011093 ! left pelvic girdle region +relationship: part_of UBERON:0011093 ! left pelvic girdle region + +[Term] +id: UBERON:0011092 +name: right pelvic girdle region +namespace: uberon +def: "A pelvic girdle region that is in the right side of a multicellular organism." [OBOL:automatic] +synonym: "right pelvic girdle" EXACT INCONSISTENT [FMA:16582] +xref: FMA:16582 +is_a: UBERON:0001271 ! pelvic girdle region +intersection_of: UBERON:0001271 ! pelvic girdle region +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: has_skeleton UBERON:0011090 ! skeleton of right pelvic girdle +relationship: in_right_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI + +[Term] +id: UBERON:0011093 +name: left pelvic girdle region +namespace: uberon +def: "A pelvic girdle region that is in the left side of a multicellular organism." [OBOL:automatic] +synonym: "left pelvic girdle" EXACT INCONSISTENT [FMA:16583] +xref: FMA:16583 +is_a: UBERON:0001271 ! pelvic girdle region +intersection_of: UBERON:0001271 ! pelvic girdle region +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: has_skeleton UBERON:0011091 ! skeleton of left pelvic girdle +relationship: in_left_side_of UBERON:0000468 ! multicellular organism +property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI + [Term] id: UBERON:0011094 name: vertebra cartilage element @@ -291588,7 +406815,10 @@ xref: EMAPA:32669 xref: VHOG:0000584 is_a: UBERON:0007844 ! cartilage element is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0011095 ! vertebra pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002412 ! vertebra property_value: RO:0002175 NCBITaxon:7764 {notes="vertebra-like cartilage in hagfish are homologous to gnathostome vertebrae. mesenchymal cells express Pax1/9 and Twist", source="PMC3157150"} property_value: UBPROP:0000012 "This class is a superclass of individual vertebral cartilage condensations. Note that EHDAA2 represents these as condensation groups" xsd:string {external_ontology="EHDAA2"} @@ -291601,6 +406831,28 @@ synonym: "vertebral pre-cartilage condensation" EXACT [VHOG:0000582] xref: EMAPA:32671 xref: VHOG:0000582 is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002412 ! vertebra + +[Term] +id: UBERON:0011096 +name: lacrimal nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0001817 ! lacrimal gland +relationship: branching_part_of UBERON:0000348 ! ophthalmic nerve +relationship: innervates UBERON:0001817 ! lacrimal gland + +[Term] +id: UBERON:0011104 +name: epiphysis of fifth metacarpal bone +is_a: UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003649 ! metacarpal bone of digit 5 +relationship: part_of UBERON:0003649 ! metacarpal bone of digit 5 [Term] id: UBERON:0011107 @@ -291651,6 +406903,11 @@ xref: SCTID:303064006 xref: Wikipedia:Humeroulnar_joint is_a: UBERON:0003839 ! forelimb joint is_a: UBERON:0011139 ! synovial limb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000976 ! humerus +intersection_of: connects UBERON:0001424 ! ulna +relationship: connects UBERON:0000976 ! humerus +relationship: connects UBERON:0001424 ! ulna relationship: part_of UBERON:0001490 {source="FMA"} ! elbow joint property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray329.png xsd:anyURI @@ -291666,9 +406923,47 @@ xref: FMA:38855 xref: SCTID:182171008 xref: Wikipedia:Humeroradial_joint is_a: UBERON:0003839 ! forelimb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000976 ! humerus +intersection_of: connects UBERON:0001423 ! radius bone +relationship: connects UBERON:0000976 ! humerus +relationship: connects UBERON:0001423 ! radius bone relationship: part_of UBERON:0001490 {source="FMA"} ! elbow joint property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/9/97/Gray329.png xsd:anyURI +[Term] +id: UBERON:0011112 +name: tibiofibular joint +is_a: UBERON:0002210 ! syndesmosis +is_a: UBERON:0003840 ! hindlimb joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0000979 ! tibia +intersection_of: connects UBERON:0001446 ! fibula +intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod +relationship: connects UBERON:0000979 ! tibia +relationship: connects UBERON:0001446 ! fibula +relationship: part_of UBERON:0003823 ! hindlimb zeugopod + +[Term] +id: UBERON:0011118 +name: tarsometatarsal joint +is_a: UBERON:0001487 ! pes joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001447 ! tarsal bone +intersection_of: connects UBERON:0001448 ! metatarsal bone +relationship: connects UBERON:0001447 ! tarsal bone +relationship: connects UBERON:0001448 ! metatarsal bone + +[Term] +id: UBERON:0011119 +name: carpometacarpal joint +is_a: UBERON:0001489 ! manus joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001435 ! carpal bone +intersection_of: connects UBERON:0002374 ! metacarpal bone +relationship: connects UBERON:0001435 ! carpal bone +relationship: connects UBERON:0002374 ! metacarpal bone + [Term] id: UBERON:0011120 name: laryngeal joint @@ -291693,6 +406988,33 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001048 ! primordium relationship: part_of UBERON:0001694 {source="EMAPA"} ! petrous part of temporal bone +[Term] +id: UBERON:0011131 +name: intermetacarpal joint +is_a: UBERON:0001489 ! manus joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002374 {cardinality="2"} ! metacarpal bone +relationship: connects UBERON:0002374 ! metacarpal bone +relationship: part_of UBERON:0004453 ! metacarpus region + +[Term] +id: UBERON:0011132 +name: intercarpal joint +is_a: UBERON:0001489 ! manus joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001435 {cardinality="2"} ! carpal bone +relationship: connects UBERON:0001435 ! carpal bone +relationship: part_of UBERON:0004452 ! carpal region + +[Term] +id: UBERON:0011133 +name: intermetatarsal joint +is_a: UBERON:0001487 ! pes joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001448 {cardinality="2"} ! metatarsal bone +relationship: connects UBERON:0001448 ! metatarsal bone +relationship: part_of UBERON:0000983 ! metatarsus region + [Term] id: UBERON:0011134 name: nonsynovial joint @@ -291709,9 +407031,22 @@ namespace: uberon def: "A cartilage element that lies between two successive vertebral centra." [ISBN:0073040584] xref: AAO:0000795 is_a: UBERON:0007844 ! cartilage element +intersection_of: UBERON:0007844 ! cartilage element +intersection_of: adjacent_to UBERON:0001075 {cardinality="2"} ! bony vertebral centrum +relationship: adjacent_to UBERON:0001075 ! bony vertebral centrum relationship: part_of UBERON:0001468 {source="FMA", source="MA"} ! intervertebral joint property_value: UBPROP:0000001 "Block of cartilage, which usually ossifies, that lies between successive vertebral centra.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000795", ontology="AAO", source="AAO:Trueb_1973"} +[Term] +id: UBERON:0011136 +name: ligament of vertebral column +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: attaches_to UBERON:0001075 ! bony vertebral centrum +relationship: attaches_to UBERON:0001075 ! bony vertebral centrum +relationship: part_of UBERON:0001130 ! vertebral column + [Term] id: UBERON:0011137 name: axial skeletal system @@ -291761,8 +407096,19 @@ synonym: "ossicle of appendicular skeleton" EXACT [OBOL:automatic] xref: VSAO:0000131 xref: XAO:0004194 is_a: UBERON:0010911 ! ossicle +intersection_of: UBERON:0010911 ! ossicle +intersection_of: part_of UBERON:0002091 ! appendicular skeleton relationship: part_of UBERON:0002091 ! appendicular skeleton +[Term] +id: UBERON:0011142 +name: axial ossicle +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0010911 ! ossicle +intersection_of: UBERON:0010911 ! ossicle +intersection_of: part_of UBERON:0002090 ! postcranial axial skeleton +relationship: part_of UBERON:0002090 ! postcranial axial skeleton + [Term] id: UBERON:0011143 name: upper urinary tract @@ -291836,6 +407182,12 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre is_a: UBERON:0010912 ! subdivision of skeleton relationship: part_of UBERON:0005884 {source="AAO"} ! hyoid arch skeleton +[Term] +id: UBERON:0011154 +name: gular region +is_a: UBERON:0003102 ! surface structure +relationship: part_of UBERON:0007811 ! craniocervical region + [Term] id: UBERON:0011156 name: facial skeleton @@ -291847,8 +407199,8 @@ synonym: "facial bone" RELATED [MA:0000318] synonym: "facial skeleton" EXACT [FMA:53673] synonym: "ossa facialia" RELATED LATIN [http://en.wikipedia.org/wiki/Facial_skeleton] synonym: "ossa facialia" RELATED LATIN [Wikipedia:Facial_skeleton] -synonym: "ossa faciei" RELATED LATIN [Wikipedia:Facial_skeleton] synonym: "ossa faciei" RELATED LATIN [http://en.wikipedia.org/wiki/Facial_skeleton] +synonym: "ossa faciei" RELATED LATIN [Wikipedia:Facial_skeleton] synonym: "viscerocranium" RELATED INCONSISTENT [MA:0000318] xref: EHDAA2:0002206 xref: EHDAA:8361 @@ -291934,6 +407286,11 @@ synonym: "craniomandibular joint" NARROW [] synonym: "jaw joint" BROAD [] xref: NCIT:C32888 is_a: UBERON:0002217 {source="abduced"} ! synovial joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0003277 ! skeleton of upper jaw +intersection_of: connects UBERON:0003278 ! skeleton of lower jaw +relationship: connects UBERON:0003277 ! skeleton of upper jaw +relationship: connects UBERON:0003278 ! skeleton of lower jaw property_value: UBPROP:0000008 "Some synapsids retained two pairs of jaw joints - quadrate-articular and tempero-mandibular, but this unusual paired condition did not last long" xsd:string {source="http://evolution.berkeley.edu"} [Term] @@ -291945,6 +407302,8 @@ xref: NCIT:C32669 xref: UMLS:C1517464 {source="ncithesaurus:Gastrointestinal_Sphincter"} is_a: UBERON:0004590 ! sphincter muscle is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0005409 ! alimentary part of gastrointestinal system relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system [Term] @@ -291952,6 +407311,7 @@ id: UBERON:0011189 name: lamina propria of large intestine namespace: uberon def: "A lamina propria that is part of a large intestine." [OBOL:automatic] +subset: human_reference_atlas synonym: "lamina propria of mucosa of large intestine" EXACT [FMA:15654] synonym: "large intestinal lamina propria" EXACT [] synonym: "large intestine lamina propria" EXACT [FMA:15654] @@ -291963,6 +407323,19 @@ is_a: UBERON:0004780 ! gastrointestinal system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001207 {source="FMA"} ! mucosa of large intestine +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0011197 +name: parathyroid epithelium +is_a: UBERON:0000486 ! multilaminar epithelium +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0006799 ! glandular epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001132 ! parathyroid gland +relationship: composed_primarily_of CL:0002260 ! epithelial cell of parathyroid gland +relationship: develops_from UBERON:0004117 ! pharyngeal pouch +relationship: part_of UBERON:0001132 ! parathyroid gland [Term] id: UBERON:0011198 @@ -291982,6 +407355,16 @@ intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0001169 {source="FMA"} ! wall of large intestine +[Term] +id: UBERON:0011200 +name: sacrococcygeal symphysis +is_a: UBERON:0001468 ! intervertebral joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001350 ! coccyx +intersection_of: connects UBERON:0003690 ! fused sacrum +relationship: connects UBERON:0001350 ! coccyx +relationship: connects UBERON:0003690 ! fused sacrum + [Term] id: UBERON:0011201 name: muscle layer of small intestine @@ -291998,8 +407381,29 @@ xref: NCIT:C33569 xref: SCTID:362145004 xref: UMLS:C0227269 {source="ncithesaurus:Small_Intestinal_Muscular_Coat"} is_a: UBERON:0012367 ! muscle layer of intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0001168 {source="FMA"} ! wall of small intestine +[Term] +id: UBERON:0011202 +name: urachus epithelium +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0006555 ! excretory tube +is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002068 ! urachus +relationship: part_of UBERON:0002068 ! urachus + +[Term] +id: UBERON:0011203 +name: urachus mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0007524 ! dense mesenchyme tissue +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0002068 ! urachus +relationship: part_of UBERON:0002068 ! urachus + [Term] id: UBERON:0011214 name: nucleus of midbrain tectum @@ -292091,7 +407495,6 @@ id: UBERON:0011234 name: fibrous membrane of synovial tendon sheath namespace: uberon xref: FMA:40877 -is_a: BFO:0000040 ! material entity is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: bounding_layer_of UBERON:0000304 ! tendon sheath @@ -292107,6 +407510,7 @@ def: "The most anterior region of the braincase. Provides structural support for xref: AAO:0000986 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0034921 ! multi organ part structure +relationship: has_developmental_contribution_from UBERON:0005945 ! neurocranial trabecula relationship: part_of UBERON:0003112 ! olfactory region property_value: IAO:0000232 "currently this is not restricted to skeletal elements, unlike UBERONREF:0000007" xsd:string @@ -292132,6 +407536,8 @@ namespace: uberon def: "A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002428 ! limb bone is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0015063 ! autopod endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0015064 ! autopod cartilage property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern xsd:anyURI @@ -292147,6 +407553,14 @@ is_a: UBERON:0002365 ! exocrine gland property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/85/Civetglands.png xsd:anyURI property_value: UBPROP:0000001 "Exocrine glands in animals which secrete scents which either repel or attract other animals, e.g. perianal glands of skunks, anal glands of weasels, musk glands of foxes, ventral glands of wood rats, and dorsal glands of peccaries[MESH:A13.820]." xsd:string {source="MESH:A13.820"} +[Term] +id: UBERON:0011265 +name: carpometacarpal joint of digit 1 +is_a: UBERON:0011119 ! carpometacarpal joint +intersection_of: UBERON:0011119 ! carpometacarpal joint +intersection_of: connects UBERON:0003645 ! metacarpal bone of digit 1 +relationship: connects UBERON:0003645 ! metacarpal bone of digit 1 + [Term] id: UBERON:0011270 name: dorsal trunk @@ -292194,6 +407608,8 @@ xref: EMAPA:18734 xref: FMA:54329 xref: SCTID:181584008 is_a: UBERON:0009565 {source="FMA"} ! nail of manual digit +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0001463 ! manual digit 1 relationship: part_of UBERON:0001463 ! manual digit 1 [Term] @@ -292212,6 +407628,8 @@ xref: EMAPA:18738 xref: FMA:54341 xref: SCTID:181583002 is_a: UBERON:0009565 {source="FMA"} ! nail of manual digit +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0003625 ! manual digit 5 relationship: part_of UBERON:0003625 ! manual digit 5 [Term] @@ -292231,6 +407649,8 @@ xref: EMAPA:18739 xref: FMA:54344 xref: SCTID:181592004 is_a: UBERON:0009567 {source="FMA"} ! nail of pedal digit +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0003631 ! pedal digit 1 relationship: part_of UBERON:0003631 ! pedal digit 1 [Term] @@ -292249,8 +407669,37 @@ xref: EMAPA:18743 xref: FMA:54356 xref: SCTID:181596001 is_a: UBERON:0009567 {source="FMA"} ! nail of pedal digit +intersection_of: UBERON:0001705 ! nail +intersection_of: part_of UBERON:0003635 ! pedal digit 5 relationship: part_of UBERON:0003635 ! pedal digit 5 +[Term] +id: UBERON:0011289 +name: pharyngobasilar fascia +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0006614 ! aponeurosis +intersection_of: UBERON:0006614 ! aponeurosis +intersection_of: part_of UBERON:0001042 ! chordate pharynx +relationship: part_of UBERON:0001042 ! chordate pharynx + +[Term] +id: UBERON:0011298 +name: submucosa of uterine tube +namespace: uberon +def: "The submucous layer of the wall of the uterine tube." [BTO:0002116] +synonym: "submucosa of fallopian tube" EXACT [] +synonym: "submucous layer of uterine tube" RELATED [BTO:0002116] +synonym: "tela submucosa tubae uterinae" EXACT LATIN [BTO:0002116] +synonym: "uterine submucosa" RELATED [] +xref: BTO:0002116 +xref: SCTID:245489008 +is_a: UBERON:0000009 ! submucosa +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 ! fallopian tube + [Term] id: UBERON:0011299 name: white matter of telencephalon @@ -292310,6 +407759,15 @@ intersection_of: UBERON:0005865 ! pre-muscle condensation intersection_of: has_potential_to_develop_into UBERON:0001575 ! extrinsic muscle of tongue relationship: has_potential_to_develop_into UBERON:0001575 ! extrinsic muscle of tongue +[Term] +id: UBERON:0011342 +name: surface of mandible +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0036215 ! anatomical surface region +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: bounding_layer_of UBERON:0001684 ! mandible +relationship: bounding_layer_of UBERON:0001684 ! mandible + [Term] id: UBERON:0011357 name: Reissner's fiber @@ -292340,6 +407798,52 @@ intersection_of: UBERON:0004537 ! blood vasculature intersection_of: part_of UBERON:0000033 ! head property_value: UBPROP:0000001 "Blood vessel part of cranial vasculature.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005297", ontology="TAO", source="ZFIN:curator"} +[Term] +id: UBERON:0011363 +name: cranial lymph vasculature +is_a: UBERON:0002200 ! vasculature of head +is_a: UBERON:0004536 ! lymph vasculature +intersection_of: UBERON:0004536 ! lymph vasculature +intersection_of: part_of UBERON:0000033 ! head + +[Term] +id: UBERON:0011364 +name: cleidocephalicus muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0001105 ! clavicle bone +intersection_of: attaches_to UBERON:0011220 ! mastoid process of temporal bone +relationship: attaches_to UBERON:0001105 ! clavicle bone +relationship: attaches_to UBERON:0011220 ! mastoid process of temporal bone +relationship: has_muscle_insertion UBERON:0011220 ! mastoid process of temporal bone +relationship: has_muscle_origin UBERON:0001105 ! clavicle bone +relationship: part_of UBERON:0011368 ! brachiocephalic muscle + +[Term] +id: UBERON:0011366 +name: cleidobrachialis muscle +is_a: UBERON:0001482 ! muscle of shoulder +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0000976 ! humerus +intersection_of: attaches_to UBERON:0001105 ! clavicle bone +intersection_of: part_of UBERON:0011364 ! cleidocephalicus muscle +relationship: attaches_to UBERON:0000976 ! humerus +relationship: attaches_to UBERON:0001105 ! clavicle bone +relationship: has_muscle_insertion UBERON:0000976 ! humerus +relationship: has_muscle_origin UBERON:0001105 ! clavicle bone +relationship: part_of UBERON:0011364 ! cleidocephalicus muscle + +[Term] +id: UBERON:0011368 +name: brachiocephalic muscle +is_a: UBERON:0001482 ! muscle of shoulder +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0000976 ! humerus +intersection_of: attaches_to UBERON:0011220 ! mastoid process of temporal bone +relationship: attaches_to UBERON:0000976 ! humerus +relationship: attaches_to UBERON:0011220 ! mastoid process of temporal bone + [Term] id: UBERON:0011374 name: prepuce @@ -292349,11 +407853,20 @@ xref: NCIT:C12323 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0034929 ! external soft tissue zone +relationship: has_part UBERON:0000344 ! mucosa relationship: part_of UBERON:0003133 ! reproductive organ relationship: transformation_of UBERON:0035004 ! preputial swelling property_value: IAO:0000232 "this is a generic sex-neutral grouping class for the male and female prepuce. Note that this structure is a combination of skin and other tissue" xsd:string property_value: UBPROP:0000007 "preputial" xsd:string +[Term] +id: UBERON:0011375 +name: skin of prepuce of clitoris +is_a: UBERON:0005298 ! skin of clitoris +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0005299 ! prepuce of clitoris +relationship: part_of UBERON:0005299 ! prepuce of clitoris + [Term] id: UBERON:0011510 name: cloacal bursa @@ -292488,6 +408001,7 @@ synonym: "limb/fin skeleton" EXACT [VSAO:0000301] synonym: "skeletal parts of limb/fin" EXACT [] synonym: "skeleton of limb/fin" EXACT [] xref: VSAO:0000301 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -292498,6 +408012,19 @@ relationship: part_of UBERON:0004708 ! paired limb/fin relationship: skeleton_of UBERON:0004708 ! paired limb/fin property_value: UBPROP:0000001 "Skeletal subdivision that is part of the paired limb/fin.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000301", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070"} +[Term] +id: UBERON:0011583 +name: stylopodial skeleton +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002472 ! stylopod +relationship: distally_connected_to UBERON:0011584 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! zeugopodial skeleton +relationship: part_of UBERON:0002472 ! stylopod +relationship: part_of UBERON:0004381 ! skeleton of limb +relationship: skeleton_of UBERON:0002472 ! stylopod + [Term] id: UBERON:0011584 name: zeugopodial skeleton @@ -292511,10 +408038,16 @@ synonym: "skeleton of zeugopod" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zeugopod skeleton" EXACT [https://orcid.org/0000-0002-6601-2165] synonym: "zygopodium" RELATED [VSAO:0005010] xref: VSAO:0005010 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0002471 ! zeugopod +relationship: distally_connected_to UBERON:0006717 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! autopodial skeleton relationship: part_of UBERON:0002471 ! zeugopod relationship: part_of UBERON:0004381 {source="VSAO"} ! skeleton of limb +relationship: proximally_connected_to UBERON:0011583 ! stylopodial skeleton +relationship: skeleton_of UBERON:0002471 ! zeugopod property_value: UBPROP:0000007 "zeugopodial" xsd:string property_value: UBPROP:0000007 "zygopodial" xsd:string @@ -292540,6 +408073,7 @@ xref: EMAPA:36439 xref: VSAO:0000071 xref: XAO:0004052 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue +relationship: produced_by CL:0000060 ! odontoblast [Term] id: UBERON:0011588 @@ -292551,6 +408085,7 @@ synonym: "preenamel tissue" EXACT [VSAO:curator] xref: VSAO:0000066 xref: XAO:0004202 is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue +relationship: produced_by CL:0000059 ! ameloblast [Term] id: UBERON:0011589 @@ -292571,6 +408106,8 @@ synonym: "diencephalon commissure" EXACT [FMA:62445] xref: FMA:62445 is_a: UBERON:0005970 ! brain commissure is_a: UBERON:0011591 ! tract of diencephalon +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: part_of UBERON:0001894 ! diencephalon [Term] id: UBERON:0011591 @@ -292580,6 +408117,8 @@ def: "An axon tract that is part of a diencephalon." [OBOL:automatic] synonym: "diencephalon tract" EXACT [FMA:62447] xref: FMA:62447 is_a: UBERON:0007702 ! tract of brain +intersection_of: UBERON:0001018 ! axon tract +intersection_of: part_of UBERON:0001894 ! diencephalon relationship: part_of UBERON:0001894 ! diencephalon [Term] @@ -292594,6 +408133,22 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre relationship: develops_from UBERON:0004068 {notes="fusion"} ! medial nasal prominence relationship: develops_from UBERON:0005868 {notes="fusion"} ! maxillary prominence +[Term] +id: UBERON:0011593 +name: maxillary tooth +is_a: UBERON:0003267 ! tooth of upper jaw +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: attaches_to UBERON:0002397 ! maxilla +relationship: attaches_to UBERON:0002397 ! maxilla + +[Term] +id: UBERON:0011594 +name: dentary tooth +is_a: UBERON:0003268 ! tooth of lower jaw +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: attaches_to UBERON:0004742 ! dentary +relationship: attaches_to UBERON:0004742 ! dentary + [Term] id: UBERON:0011595 name: jaw region @@ -292601,7 +408156,7 @@ namespace: uberon def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:32905 xref: NCIT:C114916 -is_a: BFO:0000040 ! material entity +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -292630,9 +408185,28 @@ def: "Any bone that is part of the upper jaw skeleton. This includes (when prese subset: grouping_class synonym: "upper jaw bone" EXACT [] is_a: UBERON:0012360 ! bone of jaw +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0001709 ! upper jaw region relationship: part_of UBERON:0003277 ! skeleton of upper jaw property_value: editor_note "Do not manually classify under here - bones are automatically classified" xsd:string +[Term] +id: UBERON:0011601 +name: gingiva of upper jaw +is_a: UBERON:0001828 ! gingiva +intersection_of: UBERON:0001828 ! gingiva +intersection_of: part_of UBERON:0001709 ! upper jaw region +relationship: part_of UBERON:0001709 ! upper jaw region + +[Term] +id: UBERON:0011602 +name: gingiva of lower jaw +is_a: UBERON:0001828 ! gingiva +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001828 ! gingiva +intersection_of: part_of UBERON:0001710 ! lower jaw region +relationship: part_of UBERON:0001710 ! lower jaw region + [Term] id: UBERON:0011607 name: hyomandibular cartilage @@ -292700,6 +408274,17 @@ intersection_of: develops_from UBERON:0000924 ! ectoderm intersection_of: part_of UBERON:0002424 ! oral epithelium relationship: develops_from UBERON:0009479 {source="EHDAA2"} ! ectoderm of buccopharyngeal membrane +[Term] +id: UBERON:0011645 +name: iliofemoralis muscle +is_a: CARO:0000003 ! connected anatomical structure +is_a: UBERON:0001325 ! muscle of pelvis +intersection_of: UBERON:0001325 ! muscle of pelvis +intersection_of: has_muscle_insertion UBERON:0000981 ! femur +intersection_of: has_muscle_origin UBERON:0001273 ! ilium +relationship: has_muscle_insertion UBERON:0000981 ! femur +relationship: has_muscle_origin UBERON:0001273 ! ilium + [Term] id: UBERON:0011648 name: jaw muscle @@ -292768,6 +408353,8 @@ synonym: "thoracolumbar vertebra" EXACT [] is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0004247 ! bone of dorsum is_a: UBERON:0004451 {is_inferred="true"} ! trunk or cervical vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: part_of UBERON:0009568 ! trunk region of vertebral column relationship: part_of UBERON:0009568 ! trunk region of vertebral column property_value: UBPROP:0000202 FMA:72066 @@ -292779,6 +408366,8 @@ def: "A tarsal bone that connected_to a hindlimb zeugopod skeleton." [OBOL:autom is_a: UBERON:0001447 ! tarsal bone is_a: UBERON:0014395 ! proximal mesopodial bone is_a: UBERON:0015081 ! proximal tarsal endochondral element +intersection_of: UBERON:0015081 ! proximal tarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0015082 ! proximal tarsal cartilage [Term] @@ -292819,6 +408408,8 @@ synonym: "aortic valve leaflets" EXACT [VHOG:0000819] xref: EMAPA:18627 xref: VHOG:0000819 is_a: UBERON:0011741 ! cardiac valve leaflet +intersection_of: UBERON:0011741 ! cardiac valve leaflet +intersection_of: part_of UBERON:0002137 ! aortic valve relationship: part_of UBERON:0002137 ! aortic valve relationship: part_of UBERON:0010172 {source="MP"} ! bulb of aorta property_value: UBPROP:0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000819", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} @@ -292832,6 +408423,8 @@ subset: pheno_slim xref: EMAPA:18629 xref: VHOG:0000820 is_a: UBERON:0011741 ! cardiac valve leaflet +intersection_of: UBERON:0011741 ! cardiac valve leaflet +intersection_of: part_of UBERON:0002146 ! pulmonary valve relationship: part_of UBERON:0002146 ! pulmonary valve property_value: UBPROP:0000003 "Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000820", ontology="VHOG", source="DOI:10.1161/CIRCRESAHA.109.201566 Combs MD, Yutzey KE, Heart valve development. Circulatory Research (2009)", source="http://bgee.unil.ch/"} @@ -292865,6 +408458,8 @@ xref: EHDAA:9363 xref: EMAPA:18329 xref: EMAPA:30423 is_a: UBERON:0011754 ! genital swelling +intersection_of: UBERON:0011754 ! genital swelling +intersection_of: part_of UBERON:0000474 ! female reproductive system relationship: develops_from UBERON:0006233 ! female genital tubercle relationship: part_of UBERON:0000474 ! female reproductive system @@ -292879,6 +408474,8 @@ synonym: "scrotal primordium" EXACT [] xref: EHDAA2:0001049 xref: EMAPA:30509 is_a: UBERON:0011754 ! genital swelling +intersection_of: UBERON:0011754 ! genital swelling +intersection_of: part_of UBERON:0003135 ! male reproductive organ relationship: develops_from UBERON:0006261 ! male genital tubercle relationship: part_of UBERON:0003135 ! male reproductive organ @@ -292895,6 +408492,8 @@ xref: UMLS:C1514448 {source="ncithesaurus:Primordial_Phallus"} xref: Wikipedia:Primordial_phallus is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005423 ! developing anatomical structure +union_of: UBERON:0006233 ! female genital tubercle +union_of: UBERON:0006261 ! male genital tubercle relationship: develops_from UBERON:0005876 ! undifferentiated genital tubercle relationship: part_of UBERON:0004176 ! external genitalia @@ -292932,6 +408531,15 @@ intersection_of: UBERON:0003716 ! recurrent laryngeal nerve intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism relationship: in_right_side_of UBERON:0000468 ! multicellular organism +[Term] +id: UBERON:0011769 +name: cartilaginous projection +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0004529 ! anatomical projection +intersection_of: UBERON:0004529 ! anatomical projection +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +relationship: composed_primarily_of UBERON:0002418 ! cartilage tissue + [Term] id: UBERON:0011772 name: lower jaw opening @@ -292946,6 +408554,17 @@ intersection_of: luminal_space_of UBERON:0004768 ! bone of lower jaw relationship: luminal_space_of UBERON:0004768 ! bone of lower jaw relationship: part_of UBERON:0004768 ! bone of lower jaw +[Term] +id: UBERON:0011773 +name: upper jaw opening +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0011597 ! bone of upper jaw +relationship: luminal_space_of UBERON:0011597 ! bone of upper jaw +relationship: part_of UBERON:0011597 ! bone of upper jaw + [Term] id: UBERON:0011774 name: utriculosaccular duct @@ -293040,6 +408659,11 @@ synonym: "cutaneous appendage follicle placode" EXACT [] synonym: "skin follicle placode" EXACT [] is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode +intersection_of: UBERON:0005085 ! ectodermal placode +intersection_of: has_potential_to_develop_into UBERON:0036150 ! skin appendage follicle +relationship: has_developmental_contribution_from UBERON:0001003 ! skin epidermis +relationship: has_developmental_contribution_from UBERON:0002067 ! dermis +relationship: has_potential_to_develop_into UBERON:0036150 ! skin appendage follicle [Term] id: UBERON:0011818 @@ -293066,6 +408690,7 @@ id: UBERON:0011820 name: atrioventricular region namespace: uberon def: "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas synonym: "atrial ventricular junction" RELATED [GO:0003294] synonym: "atrioventricular junction" RELATED [FMA:85125, GO:0003294] synonym: "atrioventricular segment" RELATED [PMID:21234997] @@ -293085,6 +408710,7 @@ intersection_of: part_of UBERON:0000948 ! heart relationship: connects UBERON:0002081 ! cardiac atrium relationship: connects UBERON:0002082 ! cardiac ventricle relationship: part_of UBERON:0000948 ! heart +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011821 @@ -293128,7 +408754,6 @@ xref: http://linkedlifedata.com/resource/umls/id/C1511770 xref: NCIT:C32450 xref: UMLS:C1511770 {source="ncithesaurus:Dense_Connective_Tissue"} xref: Wikipedia:Dense_connective_tissue -is_a: BFO:0000040 ! material entity is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: composed_primarily_of UBERON:0011860 ! collection of collagen fibrils @@ -293172,6 +408797,24 @@ xref: Wikipedia:Vestibular_glands is_a: UBERON:0005398 ! female reproductive gland relationship: part_of UBERON:0000997 ! mammalian vulva +[Term] +id: UBERON:0011831 +name: duct of vestibular gland +is_a: UBERON:0000058 ! duct +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0011826 ! vestibular gland +relationship: part_of UBERON:0011826 ! vestibular gland + +[Term] +id: UBERON:0011845 +name: duct of sebaceous gland +is_a: UBERON:0000058 ! duct +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0001821 ! sebaceous gland +relationship: part_of UBERON:0001821 ! sebaceous gland + [Term] id: UBERON:0011846 name: acinus of sebaceous gland @@ -293181,6 +408824,8 @@ synonym: "sebaceous gland acinus" EXACT [FMA:59657] xref: FMA:59657 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011858 ! acinus of exocrine gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] @@ -293196,6 +408841,8 @@ xref: SCTID:46926004 is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011850 ! acinus of salivary gland is_a: UBERON:0013232 ! serous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0001831 ! parotid gland relationship: part_of UBERON:0001831 ! parotid gland [Term] @@ -293207,8 +408854,19 @@ synonym: "salivary gland acinus" EXACT [FMA:59870] xref: FMA:59870 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0011858 ! acinus of exocrine gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland relationship: part_of UBERON:0001044 ! saliva-secreting gland +[Term] +id: UBERON:0011856 +name: acinus of lactiferous gland +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0011858 ! acinus of exocrine gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0001912 ! lobule of mammary gland + [Term] id: UBERON:0011857 name: acinus of lacrimal gland @@ -293254,6 +408912,9 @@ xref: Wikipedia:Internal_auditory_meatus is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: conduit_for UBERON:0001647 ! facial nerve +relationship: conduit_for UBERON:0001648 ! vestibulocochlear nerve +relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear relationship: part_of UBERON:0001846 {source="MP"} ! internal ear [Term] @@ -293264,7 +408925,6 @@ xref: FMA:63212 xref: MESH:D024022 xref: NCIT:C32339 xref: NIF_Subcellular:sao7547390221 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000476 {source="ZFA"} ! acellular anatomical structure relationship: composed_primarily_of GO:0005581 ! collagen trimer relationship: composed_primarily_of GO:0098643 ! banded collagen fibril @@ -293334,6 +408994,45 @@ intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: contributes_to_morphology_of UBERON:0001777 ! substantia propria of cornea relationship: part_of UBERON:0001777 ! substantia propria of cornea +[Term] +id: UBERON:0011875 +name: ligament of sternoclavicular joint +is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: part_of UBERON:0001469 ! sternoclavicular joint +relationship: part_of UBERON:0001469 ! sternoclavicular joint + +[Term] +id: UBERON:0011877 +name: margin of tongue +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0006800 ! anatomical line +intersection_of: UBERON:0006800 ! anatomical line +intersection_of: connects UBERON:0007371 ! superior surface of tongue +intersection_of: connects UBERON:0007373 ! inferior surface of tongue +relationship: connects UBERON:0007371 ! superior surface of tongue +relationship: connects UBERON:0007373 ! inferior surface of tongue +relationship: part_of UBERON:0001723 ! tongue + +[Term] +id: UBERON:0011878 +name: muscle layer of esophagus +namespace: uberon +def: "A muscle layer that is part of a wall of esophagus." [OBOL:automatic] +synonym: "muscle coat of esophagus" EXACT [FMA:62998] +synonym: "muscular coat of oesophagus" EXACT [FMA:62998] +synonym: "muscular layer of oesophagus" EXACT [FMA:62998] +synonym: "tela muscularis (oesophagus)" EXACT LATIN [FMA:62998, FMA:TA] +synonym: "tunica muscularis esophagi" EXACT LATIN [] +synonym: "tunica muscularis oesophageae" EXACT LATIN [FMA:TA] +xref: FMA:62998 +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0001043 ! esophagus +relationship: has_part UBERON:0001134 {notes="upper part", source="Wikipedia:Muscular_layer"} ! skeletal muscle tissue +relationship: part_of UBERON:0001096 ! wall of esophagus +property_value: UBPROP:0000010 "In the upper esophagus, part of the externa is skeletal muscle, rather than smooth muscle" xsd:string {source="WP"} + [Term] id: UBERON:0011892 name: anterior uvea @@ -293352,7 +409051,6 @@ synonym: "ventral uveal tract" EXACT [] xref: EMAPA:37417 {source="MA:th"} xref: http://www.snomedbrowser.com/Codes/Details/280656002 xref: SCTID:280656002 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000481 {source="ZFA"} ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: contributes_to_morphology_of UBERON:0001768 ! uvea @@ -293372,6 +409070,15 @@ is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland relationship: part_of UBERON:0000123 ! endoneurium +[Term] +id: UBERON:0011894 +name: lumen of vagina +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + [Term] id: UBERON:0011899 name: epimysium @@ -293431,9 +409138,20 @@ xref: EHDAA2:0000177 xref: EMAPA:16115 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0003061 ! blood island +intersection_of: UBERON:0003061 ! blood island +intersection_of: part_of UBERON:0003316 ! mesenchyme of yolk sac relationship: develops_from UBERON:0003316 {source="EHDAA2"} ! mesenchyme of yolk sac relationship: part_of UBERON:0003316 ! mesenchyme of yolk sac +[Term] +id: UBERON:0011921 +name: connecting stalk blood islands +is_a: UBERON:0007503 ! epithelial vesicle +is_a: UBERON:0010303 ! extraembryonic epithelium +is_a: UBERON:0012275 ! meso-epithelium +relationship: develops_from UBERON:0005667 ! connecting stalk mesoderm +relationship: part_of UBERON:0002331 ! umbilical cord + [Term] id: UBERON:0011922 name: cochlear basement membrane @@ -293456,7 +409174,7 @@ def: "Nerve fibers which project from cell bodies of autonomic ganglia to synaps synonym: "postganglionic autonomic fibre" RELATED [] synonym: "postganglionic nerve fiber" EXACT [FMA:5924] xref: FMA:5924 -xref: MESH:A08.663.542.100 +xref: MESH:D001338 xref: NCIT:C12648 xref: UMLS:C0004384 {source="ncithesaurus:Postganglionic_Autonomic_Fiber"} xref: Wikipedia:Postganglionic_nerve_fibers @@ -293471,7 +409189,7 @@ def: "Nerve fibers which project from the central nervous system to autonomic ga synonym: "preganglionic autonomic fibre" RELATED [] synonym: "preganglionic nerve fiber" EXACT [FMA:5923] xref: FMA:5923 -xref: MESH:A08.663.542.122 +xref: MESH:D001339 xref: NCIT:C12624 xref: Wikipedia:Preganglionic_nerve_fibers is_a: UBERON:0003041 ! trigeminal nerve fibers @@ -293502,7 +409220,7 @@ name: postganglionic parasympathetic fiber namespace: uberon def: "A cholinergic axonal fiber projecting from a parasympathetic ganglion to an effector organ." [MP:0008313] synonym: "parasympathetic postganglionic fiber" RELATED [MP:0008313] -xref: MESH:A08.663.542.100.700 +xref: MESH:D017777 xref: NCIT:C12649 xref: UMLS:C0206252 {source="ncithesaurus:Postganglionic_Parasympathetic_Fiber"} xref: Wikipedia:Postganglionic_fibers @@ -293536,6 +409254,8 @@ xref: FMA:53670 xref: SCTID:368885003 xref: Wikipedia:Nasal_hair is_a: UBERON:0010171 ! strand of hair of face +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0000004 ! nose relationship: part_of UBERON:0000004 ! nose [Term] @@ -293554,18 +409274,22 @@ xref: FMA:70661 xref: Wikipedia:Pilosebaceous_unit is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +relationship: has_part UBERON:0001821 ! sebaceous gland +relationship: has_part UBERON:0002033 ! arrector muscle of hair +relationship: has_part UBERON:0002073 ! hair follicle relationship: part_of UBERON:0006003 {source="ISBN:0123813611"} ! integumentary adnexa [Term] id: UBERON:0011933 name: vibrissa unit namespace: uberon -def: "A pilosebaceuous unit that contains a strand of virbissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves." [http://orcid.org/0000-0002-6601-2165] +def: "A pilosebaceous unit that contains a strand of vibrissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim synonym: "vibrissa" RELATED [MA:0000163] xref: EMAPA:17529 xref: MA:0000163 is_a: UBERON:0011932 ! pilosebaceous unit +property_value: RO:0002161 NCBITaxon:9606 property_value: UBPROP:0000012 "MA has distinct classes for vibrissa and vibrissa hair - the former includes the follicle and is thus not the hair proper. We model this as the 'vibrissa unit'" xsd:string {external_ontology="MA"} [Term] @@ -293617,7 +409341,6 @@ xref: MA:0001613 xref: NCIT:C77661 xref: SCTID:27633001 xref: UMLS:C0227197 {source="ncithesaurus:Glandular_Stomach"} -is_a: BFO:0000040 ! material entity is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: has_part UBERON:0006924 ! stomach glandular epithelium @@ -293636,6 +409359,47 @@ xref: MA:0001625 xref: NCIT:C77662 is_a: UBERON:0009870 ! zone of stomach +[Term] +id: UBERON:0011955 +name: left hepatic vein +namespace: uberon +def: "A hepatic vein that is part of a left lobe of liver." [OBOL:automatic] +subset: human_reference_atlas +xref: EMAPA:37164 {source="MA:th"} +xref: FMA:14339 +xref: MA:0003032 +xref: SCTID:55188000 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: part_of UBERON:0001115 ! left lobe of liver +relationship: part_of UBERON:0001115 ! left lobe of liver +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0011956 +name: right hepatic vein +namespace: uberon +def: "A hepatic vein that is part of a right lobe of liver." [OBOL:automatic] +subset: human_reference_atlas +xref: EMAPA:37377 {source="MA:th"} +xref: FMA:14338 +xref: MA:0003034 +xref: SCTID:18135006 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: part_of UBERON:0001114 ! right lobe of liver +relationship: part_of UBERON:0001114 ! right lobe of liver +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0011960 +name: articular capsule of glenohumeral joint +is_a: UBERON:0001484 ! articular capsule +intersection_of: UBERON:0001484 ! articular capsule +intersection_of: part_of UBERON:0001470 ! glenohumeral joint +relationship: part_of UBERON:0001470 ! glenohumeral joint +relationship: surrounds UBERON:0001470 ! glenohumeral joint + [Term] id: UBERON:0011967 name: costotransverse joint @@ -293648,6 +409412,36 @@ xref: Wikipedia:Costotransverse_joint is_a: UBERON:0002292 {source="FMA"} ! costovertebral joint relationship: part_of UBERON:0003252 {source="FMA"} ! thoracic rib cage +[Term] +id: UBERON:0011968 +name: radio-carpal joint +is_a: UBERON:0001491 ! wrist joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0001423 ! radius bone +intersection_of: connects UBERON:0009880 ! carpal skeleton +relationship: connects UBERON:0001423 ! radius bone + +[Term] +id: UBERON:0011971 +name: calcaneofibular ligament +is_a: UBERON:0003701 ! calcaneal tendon +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: connects UBERON:0001446 ! fibula +intersection_of: connects UBERON:0001450 ! calcaneus +relationship: connects UBERON:0001446 ! fibula +relationship: part_of UBERON:0001488 ! ankle joint + +[Term] +id: UBERON:0011972 +name: medial ligament of ankle joint +is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: connects UBERON:0000979 ! tibia +intersection_of: connects UBERON:0009879 ! tarsal skeleton +relationship: connects UBERON:0000979 ! tibia +relationship: connects UBERON:0009879 ! tarsal skeleton +relationship: part_of UBERON:0001488 ! ankle joint + [Term] id: UBERON:0011973 name: epiphysis of phalanx of pes @@ -293656,8 +409450,70 @@ def: "An epiphysis that is part of a phalanx of a pes [Automatically generated d synonym: "epiphysis of phalanx of toe" EXACT [] xref: SCTID:314621001 is_a: UBERON:0001437 ! epiphysis +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0002387 ! pes +[Term] +id: UBERON:0011974 +name: epiphysis of proximal phalanx of pes +is_a: UBERON:0004446 ! epiphysis of phalanx +is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003868 ! proximal phalanx of pes +relationship: part_of UBERON:0003868 ! proximal phalanx of pes + +[Term] +id: UBERON:0011975 +name: epiphysis of middle phalanx of pes +is_a: UBERON:0004446 ! epiphysis of phalanx +is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003866 ! middle phalanx of pes +relationship: part_of UBERON:0003866 ! middle phalanx of pes + +[Term] +id: UBERON:0011976 +name: epiphysis of distal phalanx of pes +is_a: UBERON:0004446 ! epiphysis of phalanx +is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003867 ! distal phalanx of pes +relationship: part_of UBERON:0003867 ! distal phalanx of pes + +[Term] +id: UBERON:0011977 +name: epiphysis of proximal phalanx of manus +is_a: UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0002234 ! proximal phalanx of manus +relationship: part_of UBERON:0002234 ! proximal phalanx of manus + +[Term] +id: UBERON:0011978 +name: epiphysis of middle phalanx of manus +is_a: UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003864 ! middle phalanx of manus +relationship: part_of UBERON:0003864 ! middle phalanx of manus + +[Term] +id: UBERON:0011979 +name: epiphysis of distal phalanx of manus +is_a: UBERON:0004387 ! epiphysis of phalanx of manus +intersection_of: UBERON:0001437 ! epiphysis +intersection_of: part_of UBERON:0003865 ! distal phalanx of manus +relationship: part_of UBERON:0003865 ! distal phalanx of manus + +[Term] +id: UBERON:0011980 +name: crurotarsal joint +is_a: UBERON:0001488 ! ankle joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0010720 ! hindlimb zeugopod skeleton +intersection_of: connects UBERON:0011679 ! proximal tarsal bone +relationship: connects UBERON:0011679 ! proximal tarsal bone + [Term] id: UBERON:0011997 name: coelom @@ -293700,6 +409556,14 @@ namespace: uberon xref: FMA:62811 is_a: UBERON:0001744 {source="FMA"} ! lymphoid tissue +[Term] +id: UBERON:0012070 +name: palatal tooth +is_a: UBERON:0003267 ! tooth of upper jaw +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: attaches_to UBERON:0012071 ! palate bone +relationship: attaches_to UBERON:0012071 ! palate bone + [Term] id: UBERON:0012071 name: palate bone @@ -293712,6 +409576,8 @@ xref: NCIT:C33248 xref: UMLS:C1518857 {source="ncithesaurus:Palate_Bone"} is_a: UBERON:0003457 ! head bone is_a: UBERON:0008907 ! dermal bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0007375 ! roof of mouth relationship: part_of UBERON:0012072 ! palatal part of dermatocranium property_value: IAO:0000232 "this is distinct (but not disjoint) from palatine bone" xsd:string @@ -293738,8 +409604,11 @@ xref: EMAPA:37444 {source="MA:th"} xref: FMA:59857 is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: subdivision_of UBERON:0003216 ! hard palate relationship: part_of UBERON:0003216 {source="FMA"} ! hard palate relationship: part_of UBERON:0012072 ! palatal part of dermatocranium +relationship: subdivision_of UBERON:0003216 ! hard palate [Term] id: UBERON:0012075 @@ -293755,6 +409624,75 @@ is_a: UBERON:0010522 {source="ZFA"} ! replacement element property_value: UBPROP:0000001 "Bone that forms as a replacement of another structural tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001637", ontology="TAO", source="TAO:wd"} property_value: UBPROP:0000012 "This class was introduced to be consistent with the ZFA hierarchy. The corresponding TAO term was obsoleted, and never introduced into VSAO. Note that VSAO does have replacement element." xsd:string {external_ontology="ZFA"} +[Term] +id: UBERON:0012080 +name: patella cartilage element +is_a: UBERON:0003860 ! hindlimb mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005863 ! cartilaginous condensation +intersection_of: UBERON:0005863 ! cartilaginous condensation +intersection_of: has_potential_to_develop_into UBERON:0002446 ! patella +relationship: adjacent_to UBERON:0001485 ! knee joint +relationship: develops_from UBERON:0012081 ! patella pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002446 ! patella +relationship: part_of UBERON:0001441 ! hindlimb skeleton + +[Term] +id: UBERON:0012081 +name: patella pre-cartilage condensation +is_a: UBERON:0003321 ! mesenchyme of knee +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005866 ! pre-cartilage condensation +intersection_of: UBERON:0005866 ! pre-cartilage condensation +intersection_of: has_potential_to_develop_into UBERON:0002446 ! patella +relationship: has_potential_to_develop_into UBERON:0002446 ! patella +relationship: part_of UBERON:0001441 ! hindlimb skeleton +relationship: part_of UBERON:0006256 ! knee joint primordium + +[Term] +id: UBERON:0012082 +name: bronchial lumen +namespace: uberon +def: "An anatomical cavity that is part of a bronchus." [OBOL:automatic] +synonym: "bronchial lumen" EXACT [FMA:62646] +synonym: "lumen of bronchus" EXACT [FMA:62646] +xref: FMA:62646 +xref: SCTID:199401001 +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 {source="FMA"} ! anatomical space +intersection_of: luminal_space_of UBERON:0002185 {source="FMA"} ! bronchus +relationship: luminal_space_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 {source="FMA"} ! bronchus + +[Term] +id: UBERON:0012083 +name: lumen of primary bronchus +is_a: UBERON:0012082 ! bronchial lumen +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0002182 ! main bronchus +relationship: luminal_space_of UBERON:0002182 ! main bronchus +relationship: part_of UBERON:0002182 ! main bronchus + +[Term] +id: UBERON:0012084 +name: lumen of secondary bronchus +is_a: UBERON:0012082 ! bronchial lumen +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0002183 ! lobar bronchus +relationship: luminal_space_of UBERON:0002183 ! lobar bronchus +relationship: part_of UBERON:0002183 ! lobar bronchus + +[Term] +id: UBERON:0012085 +name: lumen of tertiary bronchus +is_a: UBERON:0012082 ! bronchial lumen +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0002184 ! segmental bronchus +relationship: luminal_space_of UBERON:0002184 ! segmental bronchus +relationship: part_of UBERON:0002184 ! segmental bronchus + [Term] id: UBERON:0012102 name: buccal salivary gland @@ -293763,6 +409701,8 @@ def: "A salivary gland that is part of a cheek." [OBOL:automatic] xref: FMA:59793 xref: NCIT:C32237 is_a: UBERON:0001044 ! saliva-secreting gland +intersection_of: UBERON:0001044 ! saliva-secreting gland +intersection_of: part_of UBERON:0001567 ! cheek relationship: part_of UBERON:0001567 ! cheek [Term] @@ -293774,7 +409714,7 @@ def: "A space or gap between two consecutive teeth." [UBERON:cjm, Wikipedia:Dias synonym: "diastemata" RELATED PLURAL [] synonym: "interdental space" EXACT [] xref: FMA:77271 -xref: MESH:A14.254.333 +xref: MESH:D003970 xref: SCTID:410003009 xref: Wikipedia:Diastema_(dentistry) is_a: CARO:0000000 ! anatomical entity @@ -293848,7 +409788,12 @@ name: digitopodium region namespace: uberon def: "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." [https://github.com/obophenotype/uberon/issues/131, PHENOSCAPE:ni] synonym: "acropodium (Wagner)" RELATED [] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0012139 ! segment of autopod +intersection_of: UBERON:0012139 ! segment of autopod +intersection_of: has_skeleton UBERON:0012150 ! skeleton of digitopodium +relationship: adjacent_to UBERON:0006716 ! mesopodium region +relationship: has_skeleton UBERON:0012150 ! skeleton of digitopodium property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI property_value: UBPROP:0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:string @@ -293859,6 +409804,9 @@ namespace: uberon def: "A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005451 ! segment of manus is_a: UBERON:0012140 ! digitopodium region +intersection_of: UBERON:0012140 ! digitopodium region +intersection_of: part_of UBERON:0002398 ! manus +relationship: has_skeleton UBERON:0012151 ! skeleton of manual digitopodium property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI property_value: UBPROP:0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:string @@ -293869,6 +409817,9 @@ namespace: uberon def: "A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0005445 ! segment of pes is_a: UBERON:0012140 ! digitopodium region +intersection_of: UBERON:0012140 ! digitopodium region +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_skeleton UBERON:0012152 ! skeleton of pedal digitopodium property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI property_value: UBPROP:0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:string @@ -293879,10 +409830,14 @@ namespace: uberon def: "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." [PHENOSCAPE:ni] synonym: "digitopodium" RELATED [PHENOSCAPE:ni] synonym: "skeleton of digits" RELATED COMPARATIVE_PREFERRED [] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:0012140 ! digitopodium region relationship: part_of UBERON:0006717 ! autopodial skeleton relationship: part_of UBERON:0012140 ! digitopodium region +relationship: skeleton_of UBERON:0012140 ! digitopodium region property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI property_value: UBPROP:0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:string @@ -293893,6 +409848,8 @@ namespace: uberon def: "A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton." [https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:ni] synonym: "manual digitopodium" RELATED [] is_a: UBERON:0012150 ! skeleton of digitopodium +intersection_of: UBERON:0012150 ! skeleton of digitopodium +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0001442 ! skeleton of manus relationship: part_of UBERON:0012141 {source="FMA"} ! manual digitopodium region property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI @@ -293905,11 +409862,31 @@ namespace: uberon def: "A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton." [https://orcid.org/0000-0002-6601-2165, PHENOSCAPE:ni] synonym: "pedal digitopodium" RELATED [] is_a: UBERON:0012150 ! skeleton of digitopodium +intersection_of: UBERON:0012150 ! skeleton of digitopodium +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0001445 ! skeleton of pes relationship: part_of UBERON:0012142 ! pedal digitopodium region property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod xsd:anyURI property_value: UBPROP:0000013 "some sources call this the acropodium. see https://github.com/obophenotype/uberon/wiki/Subdivisions-of-the-autopod" xsd:string +[Term] +id: UBERON:0012167 +name: buccal fat pad +is_a: UBERON:0003566 ! head connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001567 ! cheek +relationship: part_of UBERON:0001567 ! cheek + +[Term] +id: UBERON:0012168 +name: umbilical cord blood +is_a: UBERON:0013755 ! arterial blood +intersection_of: UBERON:0000178 ! blood +intersection_of: located_in UBERON:0001310 ! umbilical artery +relationship: located_in UBERON:0001310 ! umbilical artery +relationship: part_of UBERON:0000323 ! late embryo + [Term] id: UBERON:0012172 name: stomach primordium @@ -293953,6 +409930,15 @@ def: "A vascular, red cutaneous structure attached in a sagittal plane to the do xref: SCTID:3643003 is_a: UBERON:0000021 ! cutaneous appendage +[Term] +id: UBERON:0012177 +name: skin apocrine gland +is_a: UBERON:0002419 ! skin gland +is_a: UBERON:0008974 ! apocrine gland +is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0008974 ! apocrine gland +intersection_of: part_of UBERON:0002097 ! skin of body + [Term] id: UBERON:0012180 name: head or neck skin @@ -294004,6 +409990,7 @@ name: urinary bladder vasculature namespace: uberon def: "network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]" [MP:MP] def: "Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]." [MP:MP] +subset: human_reference_atlas subset: pheno_slim synonym: "bladder vasculature" EXACT [] synonym: "blood vessel of bladder" RELATED [EMAPA:28679] @@ -294017,6 +410004,7 @@ intersection_of: UBERON:0002049 {source="EMAPA"} ! vasculature intersection_of: part_of UBERON:0001255 {source="EMAPA"} ! urinary bladder relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder relationship: part_of UBERON:0001255 ! urinary bladder +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012240 @@ -294050,6 +410038,16 @@ relationship: connects UBERON:0010390 ! lumen of urethra relationship: connects UBERON:0013514 ! space surrounding organism relationship: part_of UBERON:0000057 ! urethra +[Term] +id: UBERON:0012241 +name: male urethral meatus +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0012240 ! urethral meatus +intersection_of: UBERON:0012240 ! urethral meatus +intersection_of: part_of UBERON:0003101 ! male organism +relationship: part_of UBERON:0001299 ! glans penis +relationship: part_of UBERON:0001333 ! male urethra + [Term] id: UBERON:0012242 name: internal urethral orifice @@ -294082,6 +410080,82 @@ relationship: connects UBERON:0009958 ! bladder lumen relationship: connects UBERON:0010390 ! lumen of urethra relationship: part_of UBERON:0000057 ! urethra +[Term] +id: UBERON:0012246 +name: thyroid follicular lumen +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0005305 ! thyroid follicle +relationship: luminal_space_of UBERON:0005305 ! thyroid follicle +relationship: part_of UBERON:0005305 ! thyroid follicle +relationship: surrounded_by UBERON:0012363 ! thyroid follicle epithelium + +[Term] +id: UBERON:0012247 +name: cervical gland +is_a: UBERON:0002451 ! endometrial gland +intersection_of: UBERON:0002365 ! exocrine gland +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: part_of UBERON:0012248 ! cervical mucosa + +[Term] +id: UBERON:0012248 +name: cervical mucosa +is_a: UBERON:0001295 ! endometrium +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: part_of UBERON:0000002 ! uterine cervix + +[Term] +id: UBERON:0012249 +name: ectocervix +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000064 ! organ part +intersection_of: distalmost_part_of UBERON:0000002 ! uterine cervix +relationship: distalmost_part_of UBERON:0000002 ! uterine cervix +relationship: has_part UBERON:0010304 ! non-keratinized stratified squamous epithelium +relationship: part_of UBERON:0000002 ! uterine cervix +relationship: proximal_to UBERON:0000996 ! vagina + +[Term] +id: UBERON:0012250 +name: cervix glandular epithelium +is_a: UBERON:0004801 ! cervix epithelium +is_a: UBERON:0006799 ! glandular epithelium +intersection_of: UBERON:0006799 ! glandular epithelium +intersection_of: part_of UBERON:0000002 ! uterine cervix + +[Term] +id: UBERON:0012251 +name: ectocervical epithelium +is_a: UBERON:0004801 ! cervix epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0012249 ! ectocervix +relationship: part_of UBERON:0012249 ! ectocervix + +[Term] +id: UBERON:0012252 +name: endocervical epithelium +is_a: UBERON:0012250 ! cervix glandular epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000458 ! endocervix +relationship: part_of UBERON:0000458 ! endocervix + +[Term] +id: UBERON:0012253 +name: cervical squamo-columnar junction +is_a: UBERON:0004801 ! cervix epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: continuous_with UBERON:0006922 ! cervix squamous epithelium +intersection_of: continuous_with UBERON:0012250 ! cervix glandular epithelium +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: continuous_with UBERON:0006922 ! cervix squamous epithelium +relationship: continuous_with UBERON:0012250 ! cervix glandular epithelium + [Term] id: UBERON:0012254 name: abdominal aorta artery @@ -294142,6 +410216,7 @@ intersection_of: develops_from UBERON:0000926 ! mesoderm id: UBERON:0012276 name: endometrium glandular epithelium namespace: uberon +subset: human_reference_atlas synonym: "glandular part of endometrium" EXACT [FMA:86488] synonym: "uterine glands" EXACT [] synonym: "uterine glands set" EXACT [] @@ -294151,6 +410226,9 @@ xref: MA:0002732 is_a: UBERON:0004811 ! endometrium epithelium is_a: UBERON:0006929 ! glandular columnar epithelium is_a: UBERON:0007589 ! ciliated columnar oviduct epithelium +intersection_of: UBERON:0006799 ! glandular epithelium +intersection_of: part_of UBERON:0004811 ! endometrium epithelium +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012278 @@ -294171,6 +410249,9 @@ is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0001826 ! nasal cavity mucosa +relationship: has_part CL:0000159 ! seromucus secreting cell relationship: part_of UBERON:0001826 ! nasal cavity mucosa [Term] @@ -294187,6 +410268,9 @@ xref: NCIT:C77620 is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0015251 {source="ISBN:0123813611"} ! modified sebaceous gland is_a: UBERON:0016852 ! skin scent gland +intersection_of: UBERON:0001821 ! sebaceous gland +intersection_of: part_of UBERON:0011932 ! pilosebaceous unit +intersection_of: part_of UBERON:0012336 ! perianal skin relationship: part_of UBERON:0012336 ! perianal skin property_value: RO:0002161 NCBITaxon:9606 @@ -294199,6 +410283,8 @@ subset: pheno_slim xref: EMAPA:37901 {source="MA:th"} is_a: UBERON:0003916 ! fat pad is_a: UBERON:0004180 ! mammary gland fat +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001911 ! mammary gland [Term] id: UBERON:0012283 @@ -294208,6 +410294,21 @@ def: "Encapsulated adipose tissue associated with the femur." [MP:0008905] synonym: "femoral fat depot" EXACT [MP:0008905] is_a: UBERON:0003916 ! fat pad is_a: UBERON:0004266 ! upper leg connective tissue +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0000376 ! hindlimb stylopod + +[Term] +id: UBERON:0012287 +name: Rathkes pouch epithelium +is_a: UBERON:0004906 ! ectodermal part of digestive tract +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009854 ! digestive tract diverticulum +is_a: UBERON:0011642 ! oral epithelium from ectoderm +intersection_of: UBERON:0007499 ! epithelial sac +intersection_of: adjacent_to UBERON:0009974 ! lumen of Rathke's pouch +intersection_of: part_of UBERON:0005356 ! Rathke's pouch +relationship: adjacent_to UBERON:0009974 ! lumen of Rathke's pouch +relationship: part_of UBERON:0005356 ! Rathke's pouch [Term] id: UBERON:0012292 @@ -294362,6 +410463,7 @@ id: UBERON:0012303 name: ureteral orifice namespace: uberon def: "The slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux." [MP:0011783, Wikipedia:Orifice_of_ureter] +subset: human_reference_atlas subset: pheno_slim synonym: "Mercier's bar" EXACT [FMA:77047] synonym: "orifice of ureter" EXACT [FMA:77047] @@ -294381,9 +410483,11 @@ xref: SCTID:181415004 xref: Wikipedia:Orifice_of_ureter is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010418 ! urethral opening +relationship: contributes_to_morphology_of UBERON:0009973 ! ureterovesical junction relationship: part_of UBERON:0006082 ! fundus of urinary bladder relationship: part_of UBERON:0009973 ! ureterovesical junction property_value: editor_note "TODO - add relationship to junction" xsd:string +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012313 @@ -294413,7 +410517,7 @@ xref: FMA:293103 xref: http://www.snomedbrowser.com/Codes/Details/89066004 xref: SCTID:89066004 is_a: UBERON:0002050 ! embryonic structure -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0000033 ! head [Term] @@ -294437,6 +410541,9 @@ xref: Wikipedia:Vaginal_orifice is_a: UBERON:0000161 ! orifice is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000161 ! orifice +intersection_of: part_of UBERON:0000996 ! vagina +relationship: contributes_to_morphology_of UBERON:0000996 ! vagina relationship: part_of UBERON:0000996 ! vagina [Term] @@ -294444,6 +410551,7 @@ id: UBERON:0012318 name: anterior ethmoidal artery namespace: uberon def: "The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP]." [Wikipedia:Anterior_ethmoidal_artery] +subset: human_reference_atlas synonym: "a. ethmoidalis anterior" EXACT LATIN [Wikipedia:Anterior_ethmoidal_artery] synonym: "anterior ethmoid artery" RELATED [Wikipedia:Anterior_ethmoidal_artery] synonym: "anterior meningeal arteries" RELATED [Wikipedia:Anterior_ethmoidal_artery] @@ -294453,6 +410561,7 @@ xref: FMA:49986 xref: SCTID:312160004 xref: Wikipedia:Anterior_ethmoidal_artery is_a: UBERON:0005193 ! ethmoidal artery +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012320 @@ -294473,10 +410582,11 @@ intersection_of: part_of UBERON:0000974 ! neck id: UBERON:0012321 name: deep cervical artery namespace: uberon -def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [Wikipedia:Deep_cervical_artery] def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [http://en.wikipedia.org/wiki/Deep_cervical_artery] -synonym: "profunda cervicalis" RELATED [Wikipedia:Deep_cervical_artery] +def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [Wikipedia:Deep_cervical_artery] +subset: human_reference_atlas synonym: "profunda cervicalis" RELATED [http://en.wikipedia.org/wiki/Deep_cervical_artery] +synonym: "profunda cervicalis" RELATED [Wikipedia:Deep_cervical_artery] xref: FMA:10659 xref: http://en.wikipedia.org/wiki/Deep_cervical_artery xref: http://www.snomedbrowser.com/Codes/Details/244223002 @@ -294488,6 +410598,37 @@ intersection_of: part_of UBERON:0035551 ! deep vasculature relationship: branching_part_of UBERON:0004688 {source="FMA"} ! costo-cervical trunk relationship: part_of UBERON:0004688 ! costo-cervical trunk relationship: part_of UBERON:0035551 ! deep vasculature +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0012324 +name: transverse cervical artery +namespace: uberon +def: "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." [Wikipedia:Transverse_cervical_artery] +subset: human_reference_atlas +synonym: "cervical artery" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "cervical artery" RELATED [MA:0001936] +synonym: "cervical transverse artery" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "descending branch of the transverse cervical" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "transversalis artery colli" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "transversalis colli artery" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "transverse cervical" RELATED [Wikipedia:Transverse_cervical_artery] +synonym: "transverse cervical vessels" RELATED [Wikipedia:Transverse_cervical_artery] +xref: FMA:10664 +xref: MA:0001936 +xref: SCTID:244224008 +xref: Wikipedia:Transverse_cervical_artery +is_a: UBERON:0012320 ! cervical artery +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000012 "Unclear if MA class belongs here or in parent" xsd:string {external_ontology="MA"} + +[Term] +id: UBERON:0012329 +name: keratinized stratified squamous epithelium +is_a: UBERON:0006915 ! stratified squamous epithelium +intersection_of: UBERON:0006915 ! stratified squamous epithelium +intersection_of: has_part GO:0045095 ! keratin filament +relationship: has_part GO:0045095 ! keratin filament [Term] id: UBERON:0012330 @@ -294502,6 +410643,9 @@ xref: NCIT:C77659 xref: UMLS:C2698431 {source="ncithesaurus:Nasal-Associated_Lymphoid_Tissue"} is_a: UBERON:0001962 ! gut-associated lymphoid tissue is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: overlaps UBERON:0005022 ! mucosa of nasopharynx relationship: part_of UBERON:0001728 ! nasopharynx [Term] @@ -294509,6 +410653,7 @@ id: UBERON:0012332 name: broad ligament of uterus namespace: uberon def: "A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis." [MESH:A02.513.170, Wikipedia:Broad_ligament_of_the_uterus] +subset: human_reference_atlas synonym: "broad ligament" RELATED [MESH:A02.513.170] synonym: "broad uterine ligament" EXACT [FMA:16516] synonym: "ligamentum latum uteri" RELATED LATIN [] @@ -294520,7 +410665,10 @@ xref: UMLS:C0006205 {source="ncithesaurus:Broad_Ligament"} xref: Wikipedia:Broad_ligament_of_the_uterus is_a: UBERON:0000211 {source="MESH"} ! ligament is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: connects UBERON:0000459 ! uterine wall +relationship: connects UBERON:0002355 ! pelvic region of trunk relationship: part_of UBERON:0002095 ! mesentery +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012333 @@ -294544,6 +410692,7 @@ xref: FMA:29350 xref: MA:0003046 xref: SCTID:181522009 is_a: UBERON:0001415 ! skin of pelvis +relationship: surrounds UBERON:0001245 ! anus [Term] id: UBERON:0012344 @@ -294566,6 +410715,17 @@ is_a: UBERON:0015790 ! autopod skin property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/8/8d/Paw_and_pads.jpg xsd:anyURI property_value: editor_note "See https://github.com/obophenotype/uberon/issues/1305" xsd:string +[Term] +id: UBERON:0012351 +name: urachal lumen +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0002068 ! urachus +relationship: luminal_space_of UBERON:0002068 ! urachus +relationship: part_of UBERON:0002068 ! urachus + [Term] id: UBERON:0012352 name: mesangial matrix @@ -294587,10 +410747,35 @@ synonym: "acropodial limb segment" EXACT [] synonym: "acropodial region" EXACT [] synonym: "acropodial segment of autopod" EXACT [] synonym: "set of digits" EXACT [] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0012139 ! segment of autopod +intersection_of: UBERON:0012139 ! segment of autopod +intersection_of: has_skeleton UBERON:0010543 ! acropodial skeleton +relationship: distal_to UBERON:0009877 ! metapodium region +relationship: has_skeleton UBERON:0010543 ! acropodial skeleton relationship: part_of UBERON:0012140 ! digitopodium region property_value: IAO:0000232 "class refers to an entire limb segment, not just the bones" xsd:string +[Term] +id: UBERON:0012355 +name: manual acropodium region +is_a: UBERON:0005451 ! segment of manus +is_a: UBERON:0012354 ! acropodium region +intersection_of: UBERON:0012354 ! acropodium region +intersection_of: part_of UBERON:0002398 ! manus +relationship: has_skeleton UBERON:0010688 ! skeleton of manual acropodium +relationship: part_of UBERON:0012141 ! manual digitopodium region + +[Term] +id: UBERON:0012356 +name: pedal acropodium region +is_a: UBERON:0005445 ! segment of pes +is_a: UBERON:0012354 ! acropodium region +intersection_of: UBERON:0012354 ! acropodium region +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_skeleton UBERON:0010696 ! skeleton of pedal acropodium +relationship: part_of UBERON:0012142 ! pedal digitopodium region + [Term] id: UBERON:0012357 name: digitopodium bone @@ -294598,6 +410783,8 @@ namespace: uberon def: "A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton." [https://orcid.org/0000-0002-6601-2165] synonym: "digit bone" RELATED COMPARATIVE_PREFERRED [] is_a: UBERON:0011250 ! autopod bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: part_of UBERON:0012140 ! digitopodium region relationship: part_of UBERON:0012150 ! skeleton of digitopodium property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern @@ -294610,6 +410797,8 @@ synonym: "bone of forelimb digitopodium" EXACT [] xref: SCTID:265809008 is_a: UBERON:0005897 ! manus bone is_a: UBERON:0012357 ! digitopodium bone +intersection_of: UBERON:0012357 ! digitopodium bone +intersection_of: part_of UBERON:0002398 ! manus relationship: part_of UBERON:0012151 ! skeleton of manual digitopodium property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern @@ -294621,6 +410810,8 @@ def: "A bone that is part of a the pedal digitopodium skeleton - i.e. the toes o synonym: "bone of hindlimb digitopodium" EXACT [] is_a: UBERON:0005899 ! pes bone is_a: UBERON:0012357 ! digitopodium bone +intersection_of: UBERON:0012357 ! digitopodium bone +intersection_of: part_of UBERON:0002387 ! pes relationship: part_of UBERON:0012152 ! skeleton of pedal digitopodium property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern @@ -294649,6 +410840,16 @@ xref: EHDAA2:0004588 is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of UBERON:0001353 {source="EHDAA2"} ! anal region +[Term] +id: UBERON:0012363 +name: thyroid follicle epithelium +is_a: UBERON:0000484 ! simple cuboidal epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0005305 ! thyroid follicle +relationship: develops_from UBERON:0007689 ! thyroid diverticulum +relationship: part_of UBERON:0005305 ! thyroid follicle + [Term] id: UBERON:0012367 name: muscle layer of intestine @@ -294691,6 +410892,14 @@ xref: FMA:62900 is_a: UBERON:0034933 ! layer of smooth muscle tissue relationship: part_of UBERON:0006660 ! muscular coat +[Term] +id: UBERON:0012373 +name: sympathetic nerve plexus +is_a: UBERON:0001816 ! autonomic nerve plexus +intersection_of: UBERON:0001810 ! nerve plexus +intersection_of: part_of UBERON:0000013 ! sympathetic nervous system +relationship: part_of UBERON:0000013 ! sympathetic nervous system + [Term] id: UBERON:0012375 name: subserosa @@ -294698,6 +410907,7 @@ namespace: uberon def: "A layer of tissue between the muscularis and serosa." [Wikipedia:Subserosa] def: "A layer of tissue between the muscularis and serosa." [http://en.wikipedia.org/wiki/Subserosa] comment: Contains nerves, blood vessels, lymphatics and lymph nodes +subset: human_reference_atlas xref: FMA:45636 xref: http://en.wikipedia.org/wiki/Subserosa xref: http://linkedlifedata.com/resource/umls/id/C0225334 @@ -294706,7 +410916,6 @@ xref: NCIT:C94494 xref: SCTID:2255006 xref: UMLS:C0225334 {source="ncithesaurus:Subserosa"} xref: Wikipedia:Subserosa -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -294714,26 +410923,32 @@ intersection_of: adjacent_to UBERON:0000042 ! serous membrane intersection_of: composed_primarily_of UBERON:0006815 ! areolar connective tissue relationship: adjacent_to UBERON:0000042 ! serous membrane relationship: composed_primarily_of UBERON:0006815 ! areolar connective tissue -relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012377 name: muscle layer of jejunum namespace: uberon def: "A muscular coat that is part of a jejunum." [OBOL:automatic] +subset: human_reference_atlas synonym: "jejunal smooth muscle" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "muscularis externa of jejunum" EXACT [FMA:14951] synonym: "muscularis propria of jejunum" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "smooth muscle of jejunum" RELATED [https://orcid.org/0000-0002-6601-2165] xref: FMA:14951 is_a: UBERON:0011201 ! muscle layer of small intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0002115 ! jejunum relationship: part_of UBERON:0002115 ! jejunum +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012378 name: muscle layer of urinary bladder namespace: uberon def: "A muscular coat that is part of a urinary bladder." [OBOL:automatic] +subset: human_reference_atlas synonym: "bladder muscular coat" EXACT [] synonym: "muscle layer of urinary bladder" EXACT [FMA:15930] synonym: "muscular coat of bladder" EXACT [FMA:15930] @@ -294752,11 +410967,13 @@ intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0001255 ! urinary bladder relationship: has_part UBERON:0004228 ! urinary bladder smooth muscle relationship: part_of UBERON:0001256 {source="FMA"} ! wall of urinary bladder +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012416 name: respiratory system arterial smooth muscle namespace: uberon +subset: human_reference_atlas xref: EMAPA:37567 {source="MA:th"} xref: MA:0001802 is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle @@ -294764,18 +410981,52 @@ is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003643 ! respiratory system arterial blood vessel relationship: part_of UBERON:0003643 ! respiratory system arterial blood vessel +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012418 name: respiratory system venous smooth muscle namespace: uberon def: "A smooth muscle tissue that is part of a respiratory system venous blood vessel." [OBOL:automatic] +subset: human_reference_atlas xref: EMAPA:37586 {source="MA:th"} xref: MA:0001812 is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0003476 ! respiratory system venous blood vessel relationship: part_of UBERON:0003476 ! respiratory system venous blood vessel +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0012423 +name: layer of microvilli +namespace: uberon +def: "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." [GO:0005902, Wikipedia:Microvillus] +synonym: "microvilli" RELATED [MESH:A11.284.180.565] +synonym: "microvillus" RELATED [FMA:67296] +xref: FMA:67296 +xref: MESH:D008871 +xref: NCIT:C33112 +xref: UMLS:C0026049 {source="ncithesaurus:Microvillus"} +xref: Wikipedia:Microvillus +is_a: UBERON:0005162 ! multi cell part structure +relationship: composed_primarily_of GO:0005902 ! microvillus +property_value: UBPROP:0000009 "a wide variety of physiological and cellular functions including absorption, secretion, cellular adhesion, and mechanotransduction" xsd:string +property_value: UBPROP:0000009 "increases the surface area of a cell lining whilst minimizing increase in volume" xsd:string +property_value: UBPROP:0000012 "FMA class represents an individual microvillus." xsd:string {external_ontology="FMA"} + +[Term] +id: UBERON:0012425 +name: striated border microvillus layer +namespace: uberon +def: "A microvillus layer that is striated and found in the intestine." [http://medical-dictionary.thefreedictionary.com/striated+border, http://orcid.org/0000-0002-6601-2165] +synonym: "striated border" RELATED [FMA:70978] +xref: FMA:70978 +xref: NCIT:C33634 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0012423 ! layer of microvilli +relationship: part_of UBERON:0000160 ! intestine +property_value: UBPROP:0000012 "FMA class represents an individual microvillus" xsd:string {external_ontology="FMA"} [Term] id: UBERON:0012429 @@ -294825,6 +411076,17 @@ relationship: part_of UBERON:0010230 ! eyeball of camera-type eye property_value: RO:0002175 NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"} property_value: RO:0002175 NCBITaxon:7955 {source="https://doi.org/10.1177/0192623311409597"} +[Term] +id: UBERON:0012437 +name: epithelial-mesenchymal boundary +is_a: UBERON:0006800 ! anatomical line +intersection_of: UBERON:0006800 ! anatomical line +intersection_of: adjacent_to UBERON:0000483 ! epithelium +intersection_of: adjacent_to UBERON:0003104 ! mesenchyme +relationship: adjacent_to UBERON:0000483 ! epithelium +relationship: adjacent_to UBERON:0003104 ! mesenchyme +relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa + [Term] id: UBERON:0012449 name: mechanoreceptor @@ -294832,7 +411094,7 @@ namespace: uberon def: "A sensory receptor that responds to mechanical pressure or distortion." [Wikipedia:Mechanoreceptor] comment: Normally there are four main types in glabrous skin: Pacinian corpuscles, Meissner's corpuscles, Merkel's discs, and Ruffini endings. There are also mechanoreceptors in hairy skin, and the hair cells in the cochlea are the most sensitive mechanoreceptors, transducing air pressure waves into nerve signals sent to the brain. In the periodontal ligament, there are some mechanoreceptors, which allow the jaw to relax when biting down on hard objects; the mesencephalic nucleus is responsible for this reflex xref: FMA:86587 -xref: MESH:A08.800.550.700.500 +xref: MESH:D008465 xref: NCIT:C13821 xref: Wikipedia:Mechanoreceptor is_a: UBERON:0012451 ! sensory receptor @@ -294869,7 +411131,7 @@ def: "A sensory nerve ending that responds to a stimulus in the internal or exte synonym: "peripheral ending of sensory neuron" EXACT [FMA:84650] synonym: "sensory nerve ending" RELATED [MESH:A08.800.550.700] xref: FMA:84650 -xref: MESH:A08.800.550.700 +xref: MESH:D011984 xref: NCIT:C13819 xref: SCTID:70402007 xref: UMLS:C0682664 {source="ncithesaurus:Somatosensory_Receptor"} @@ -294938,6 +411200,7 @@ id: UBERON:0012463 name: cloacal lumen namespace: uberon def: "A anatomical space that is enclosed by a cloaca." [OBOL:automatic] +def: "An anatomical space that is enclosed by a cloaca." [OBOL:automatic] synonym: "cloaca lumen" EXACT [ZFA:0000330] synonym: "cloacal chamber" EXACT [ZFA:0000330] xref: TAO:0000330 @@ -294971,6 +411234,7 @@ id: UBERON:0012465 name: lumen of terminal part of digestive tract namespace: uberon def: "A anatomical space that is enclosed by a terminal part of digestive tract." [OBOL:automatic] +def: "An anatomical space that is enclosed by a terminal part of digestive tract." [OBOL:automatic] is_a: BFO:0000141 ! immaterial entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000464 ! anatomical space @@ -295002,6 +411266,18 @@ def: "An anatomical space with no opening to another space or to the exterior." synonym: "closed anatomical space" EXACT [] xref: AEO:0000222 is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: has_quality PATO:0000608 ! closed +relationship: has_quality PATO:0000608 ! closed + +[Term] +id: UBERON:0012468 +name: anal tooth +is_a: UBERON:0003913 ! tooth-like structure +intersection_of: UBERON:0003913 ! tooth-like structure +intersection_of: part_of UBERON:0001353 ! anal region +relationship: only_in_taxon NCBITaxon:7586 ! Echinodermata +relationship: part_of UBERON:0001353 ! anal region [Term] id: UBERON:0012469 @@ -295024,6 +411300,7 @@ synonym: "set of bones of upper limb" RELATED [FMA:24139] synonym: "skeleton of anterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165] synonym: "upper limb skeleton" RELATED [FMA:24139] xref: FMA:24139 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0010708 ! pectoral complex @@ -295044,6 +411321,7 @@ synonym: "pelvic complex skeleton" RELATED [https://orcid.org/0000-0002-6601-216 synonym: "set of bones of lower limb" RELATED [FMA:24140] synonym: "skeleton of posterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165] xref: FMA:24140 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: skeleton_of UBERON:0010709 ! pelvic complex @@ -295073,6 +411351,7 @@ xref: FMA:24189 xref: SCTID:182326009 xref: SCTID:304036007 is_a: UBERON:0005434 {source="FMA"} ! cervical region +relationship: BSPO:0015101 UBERON:0000974 ! neck relationship: part_of UBERON:0001137 {source="FMA"} ! dorsum property_value: UBPROP:0000007 "nuchal" xsd:string @@ -295150,6 +411429,17 @@ intersection_of: UBERON:0000042 ! serous membrane intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca +[Term] +id: UBERON:0012485 +name: cloacal villus +namespace: uberon +synonym: "cloacal villi" EXACT PLURAL [] +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0012423 ! layer of microvilli +intersection_of: UBERON:0012423 ! layer of microvilli +intersection_of: part_of UBERON:0000162 ! cloaca +relationship: part_of UBERON:0000162 ! cloaca + [Term] id: UBERON:0012486 name: muscle layer of cloaca @@ -295162,11 +411452,38 @@ intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0000162 ! cloaca relationship: part_of UBERON:0000162 ! cloaca +[Term] +id: UBERON:0012487 +name: vaginal sphincter +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + +[Term] +id: UBERON:0012488 +name: muscle layer of duodenum +namespace: uberon +def: "A muscular coat that is part of a duodenum." [OBOL:automatic] +synonym: "duodenal muscularis propria" EXACT [FMA:14944] +synonym: "muscularis externa of duodenum" EXACT [FMA:14944] +synonym: "muscularis propria of duodenum" RELATED [https://orcid.org/0000-0002-6601-2165] +synonym: "smooth muscle of duodenum" RELATED [https://orcid.org/0000-0002-6601-2165] +xref: FMA:14944 +xref: SCTID:362147007 +is_a: UBERON:0011201 ! muscle layer of small intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0002114 ! duodenum + [Term] id: UBERON:0012489 name: muscle layer of colon namespace: uberon def: "A muscular coat that is part of a colon." [OBOL:automatic] +subset: human_reference_atlas synonym: "colon muscularis" RELATED [MA:0003198] synonym: "colonic muscularis propria" EXACT [FMA:14986] synonym: "muscular coat of colon" EXACT [FMA:14986] @@ -295177,10 +411494,12 @@ xref: EMAPA:27383 xref: FMA:14986 xref: http://www.snomedbrowser.com/Codes/Details/362158003 xref: MA:0003198 +xref: SCTID:362158003 is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0001155 ! colon relationship: part_of UBERON:0001155 ! colon +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012490 @@ -295195,12 +411514,49 @@ synonym: "muscularis externa of anal canal" EXACT [] synonym: "muscularis propria of anal canal" EXACT [FMA:15708] xref: FMA:15708 xref: http://www.snomedbrowser.com/Codes/Details/362171000 +xref: SCTID:362171000 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011198 ! muscle layer of large intestine intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal +[Term] +id: UBERON:0012498 +name: serosa of appendix +is_a: UBERON:0001209 ! serosa of large intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:0012499 +name: serosa of uterine tube +namespace: uberon +def: "A serous membrane that is part of a fallopian tube." [OBOL:automatic] +synonym: "serosa of fallopian tube" EXACT [FMA:18316] +synonym: "serosa of oviduct" EXACT [FMA:18316] +synonym: "serous coat of uterine tube" EXACT [FMA:18316] +synonym: "tunica serosa (tuba uterina)" EXACT [FMA:18316] +synonym: "tunica serosa tubae uterinae" EXACT [FMA:TA] +synonym: "uterine tubal serosa" EXACT [FMA:18316] +synonym: "uterine tube serosa" EXACT [FMA:18316] +xref: FMA:18316 +xref: SCTID:259593000 +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 ! fallopian tube + +[Term] +id: UBERON:0012503 +name: serosa of fundus of stomach +is_a: UBERON:0001201 ! serosa of stomach +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0001160 ! fundus of stomach +relationship: part_of UBERON:0001160 ! fundus of stomach + [Term] id: UBERON:0012504 name: adventitia of esophagus @@ -295220,6 +411576,15 @@ intersection_of: UBERON:0005742 ! adventitia intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus +[Term] +id: UBERON:0012615 +name: umbilical smooth muscle +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005292 ! extraembryonic tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0002331 ! umbilical cord +relationship: part_of UBERON:0002331 ! umbilical cord + [Term] id: UBERON:0012641 name: body of tubeworm @@ -295255,6 +411620,57 @@ def: "Organ at the distal end of a tubeworm. Helps anchor the tubeworm." [http:/ is_a: UBERON:0000062 ! organ relationship: part_of UBERON:0012641 ! body of tubeworm +[Term] +id: UBERON:0012650 +name: gastroduodenal junction +namespace: uberon +def: "An anatomical junction that connects a stomach and connects a duodenum." [OBOL:automatic] +xref: FMA:17046 +xref: SCTID:264014000 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0000945 ! stomach +intersection_of: connects UBERON:0002114 ! duodenum +relationship: connects UBERON:0000945 ! stomach +relationship: connects UBERON:0002114 ! duodenum +relationship: part_of UBERON:0000945 ! stomach + +[Term] +id: UBERON:0012651 +name: mucosa of gastroduodenal junction +namespace: uberon +def: "A mucosa that is part of a gastroduodenal junction." [OBOL:automatic] +synonym: "gastroduodenal mucosa" EXACT [BTO:0005415] +xref: BTO:0005415 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0012650 ! gastroduodenal junction +relationship: part_of UBERON:0012650 ! gastroduodenal junction + +[Term] +id: UBERON:0012652 +name: colorectum +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: has_part UBERON:0001052 ! rectum +relationship: has_part UBERON:0001155 ! colon +relationship: part_of UBERON:0000059 ! large intestine + +[Term] +id: UBERON:0013067 +name: colorectal mucosa +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: part_of UBERON:0012652 ! colorectum +relationship: part_of UBERON:0012652 ! colorectum + +[Term] +id: UBERON:0013069 +name: popliteal area +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005055 ! zone of long bone +relationship: part_of UBERON:0000981 ! femur + [Term] id: UBERON:0013118 name: sulcus of brain @@ -295269,8 +411685,8 @@ synonym: "sulci & spaces" BROAD PLURAL [HBA:9352] synonym: "sulcus" BROAD [NLX:144078] xref: DHBA:10610 xref: HBA:9352 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1208 xref: NCIT:C32292 +xref: neuronames:1208 xref: SCTID:279337001 xref: Wikipedia:Sulcus_(neuroanatomy) is_a: CARO:0000000 ! anatomical entity @@ -295280,6 +411696,24 @@ property_value: editor_note "sulci are considered absent from lissencephalic mam property_value: RO:0002174 NCBITaxon:10088 property_value: UBPROP:0000001 "Indentation on the surface of the brain or spinal cord that forms a recognizable landmark, e.g., central sulcus, sulcus limitans (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"} +[Term] +id: UBERON:0013121 +name: proximal epiphysis of phalanx of pes +is_a: UBERON:0004447 ! proximal epiphysis of phalanx +is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0004380 ! proximal epiphysis +intersection_of: part_of UBERON:0001449 ! phalanx of pes +relationship: part_of UBERON:0001449 ! phalanx of pes + +[Term] +id: UBERON:0013122 +name: distal epiphysis of phalanx of pes +is_a: UBERON:0004448 ! distal epiphysis of phalanx +is_a: UBERON:0011973 ! epiphysis of phalanx of pes +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0001449 ! phalanx of pes +relationship: part_of UBERON:0001449 ! phalanx of pes + [Term] id: UBERON:0013126 name: vein of abdomen @@ -295316,6 +411750,25 @@ relationship: drains UBERON:0001833 ! lip relationship: part_of UBERON:0001653 ! facial vein relationship: tributary_of UBERON:0001653 {source="FMA"} ! facial vein +[Term] +id: UBERON:0013139 +name: ligament of liver +namespace: uberon +def: "A nonskeletal ligament that is part of a liver." [OBOL:automatic] +synonym: "hepatic ligament" EXACT [FMA:15820] +synonym: "liver ligament" EXACT [] +xref: FMA:15820 +xref: NCIT:C32997 +xref: SCTID:48536008 +xref: UMLS:C0230238 {source="ncithesaurus:Liver_Ligament"} +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005172 ! abdomen element +is_a: UBERON:0008845 ! nonskeletal ligament +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0008845 ! nonskeletal ligament +intersection_of: part_of UBERON:0002107 ! liver +relationship: part_of UBERON:0002107 ! liver + [Term] id: UBERON:0013140 name: systemic vein @@ -295376,8 +411829,8 @@ synonym: "early brain vesicle" EXACT [] synonym: "primary brain vesicle" NARROW [] synonym: "primitive brain vesicle" EXACT [] synonym: "secondary brain vesicle" NARROW [] -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2499 xref: NCIT:C34259 +xref: neuronames:2499 xref: SCTID:360409004 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010064 {source="EHDAA2"} ! open anatomical space @@ -295386,6 +411839,14 @@ relationship: part_of UBERON:0006238 ! future brain property_value: editor_note "consider adding all secondary vesicles (e.g. diencephalic; my/metencephalic. See http://www.dartmouth.edu/~rswenson/NeuroSci/chapter_4.html)." xsd:string property_value: UBPROP:0000012 "Note that some sources may treat the term vesicle as the progenitor of the whole brain region; for example 'The retina develops directly from the neural tube as an outpouching from the diencephalic vesicle'" xsd:string +[Term] +id: UBERON:0013151 +name: choroidal artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001886 ! choroid plexus +relationship: supplies UBERON:0001886 ! choroid plexus + [Term] id: UBERON:0013156 name: 1st arch mandibular endoderm @@ -295412,6 +411873,43 @@ intersection_of: UBERON:0002530 ! gland intersection_of: part_of UBERON:0006235 ! foregut-midgut junction relationship: part_of UBERON:0006235 ! foregut-midgut junction +[Term] +id: UBERON:0013159 +name: epithalamus mantle layer +is_a: UBERON:0004061 ! neural tube mantle layer +intersection_of: UBERON:0004061 ! neural tube mantle layer +intersection_of: part_of UBERON:0001899 ! epithalamus +relationship: develops_from UBERON:0009580 ! diencephalon mantle layer +relationship: part_of UBERON:0001899 ! epithalamus + +[Term] +id: UBERON:0013160 +name: epithalamus ventricular layer +is_a: UBERON:0004060 ! neural tube ventricular layer +intersection_of: UBERON:0004060 ! neural tube ventricular layer +intersection_of: part_of UBERON:0001899 ! epithalamus +relationship: part_of UBERON:0001899 ! epithalamus + +[Term] +id: UBERON:0013161 +name: left lateral ventricle +is_a: UBERON:0002285 ! telencephalic ventricle +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002285 ! telencephalic ventricle +intersection_of: in_left_side_of UBERON:0001893 ! telencephalon +relationship: in_left_side_of UBERON:0001893 ! telencephalon +relationship: part_of UBERON:0002812 ! left cerebral hemisphere + +[Term] +id: UBERON:0013162 +name: right lateral ventricle +is_a: UBERON:0002285 ! telencephalic ventricle +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002285 ! telencephalic ventricle +intersection_of: in_right_side_of UBERON:0001893 ! telencephalon +relationship: in_right_side_of UBERON:0001893 ! telencephalon +relationship: part_of UBERON:0002813 ! right cerebral hemisphere + [Term] id: UBERON:0013164 name: molariform tooth @@ -295427,6 +411925,7 @@ id: UBERON:0013191 name: ovarian cortex namespace: uberon def: "The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles." [MGI:anna] +subset: human_reference_atlas subset: pheno_slim synonym: "cortex of ovary" EXACT [FMA:18613] synonym: "cortex ovarii (zona parenchymatosa)" EXACT [FMA:18613] @@ -295437,7 +411936,10 @@ xref: UMLS:C0227878 {source="ncithesaurus:Ovarian_Cortex"} is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0001851 ! cortex is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0006960 ! ovary stroma +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0013192 @@ -295456,6 +411958,8 @@ xref: Wikipedia:Medulla_of_ovary is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000958 ! medulla of organ is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0000992 ! ovary relationship: part_of UBERON:0000992 ! ovary property_value: UBPROP:0000010 "composed of loose connective tissue that contains blood vessels, lymph vessels and nerves" xsd:string {source="NCIT"} @@ -295484,6 +411988,15 @@ is_a: UBERON:0000481 ! multi-tissue structure relationship: part_of UBERON:0003100 ! female organism property_value: UBPROP:0000001 "An udder is an organ formed of the mammary glands of female quadruped mammals, especially ruminants such as cattle, goats, sheep and deer. The udder is a single mass hanging beneath the animal, consisting of pairs of mammary glands. In cattle there are normally two pairs, in sheep, goats and deer there is one pair, and in some animals such as pigs there are many pairs. Udder care and hygiene in cows is important in milking, aiding uninterrupted and untainted milk production, and preventing mastitis. Products exist to soothe the chapped skin of the udder. This helps prevent bacterial infection, and reduces irritation during milking by the cups, and so the cow is less likely to kick the cups off[Wikipedia:Udder]." xsd:string {source="Wikipedia:Udder"} +[Term] +id: UBERON:0013228 +name: sweat gland of eyelid +is_a: UBERON:0000382 ! apocrine sweat gland +is_a: UBERON:0003605 ! eye skin gland +is_a: UBERON:0013229 ! eyelid gland +intersection_of: UBERON:0000382 ! apocrine sweat gland +intersection_of: part_of UBERON:0001711 ! eyelid + [Term] id: UBERON:0013229 name: eyelid gland @@ -295494,6 +412007,8 @@ xref: SCTID:280574000 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0001711 ! eyelid relationship: part_of UBERON:0001711 ! eyelid [Term] @@ -295503,6 +412018,8 @@ namespace: uberon def: "Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids)." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003484 ! eye sebaceous gland is_a: UBERON:0013229 ! eyelid gland +intersection_of: UBERON:0001821 ! sebaceous gland +intersection_of: part_of UBERON:0001711 ! eyelid [Term] id: UBERON:0013232 @@ -295529,6 +412046,7 @@ synonym: "ventral region" BROAD [] synonym: "ventral region of organism" EXACT [] xref: FMA:259204 is_a: UBERON:0000475 ! organism subdivision +relationship: only_in_taxon NCBITaxon:33213 ! Bilateria property_value: UBPROP:0000007 "ventral" xsd:string [Term] @@ -295537,6 +412055,9 @@ name: future glans namespace: uberon is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0005423 ! developing anatomical structure +union_of: UBERON:0013239 ! future glans penis +union_of: UBERON:0013240 ! future glans clitoris +relationship: has_potential_to_develop_into UBERON:0035651 ! glans relationship: part_of UBERON:0011757 ! differentiated genital tubercle [Term] @@ -295547,8 +412068,18 @@ def: "A future glans that is part of a male genital tubercle." [OBOL:automatic] synonym: "glans of male genital tubercle" EXACT [] xref: EMAPA:29252 is_a: UBERON:0013238 ! future glans +intersection_of: UBERON:0013238 ! future glans +intersection_of: part_of UBERON:0006261 ! male genital tubercle relationship: part_of UBERON:0006261 {source="EMAPA"} ! male genital tubercle +[Term] +id: UBERON:0013240 +name: future glans clitoris +is_a: UBERON:0013238 ! future glans +intersection_of: UBERON:0013238 ! future glans +intersection_of: part_of UBERON:0006233 ! female genital tubercle +relationship: part_of UBERON:0006233 ! female genital tubercle + [Term] id: UBERON:0013241 name: embryonic urethral groove @@ -295569,6 +412100,36 @@ relationship: develops_from UBERON:0004876 {source="Wikipedia"} ! urogenital fol property_value: UBPROP:0000008 "In humans, the urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. It typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week" xsd:string {source="Wikipedia:Urethral_groove"} property_value: UBPROP:0000008 "In humans, the urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. It typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week" xsd:string {source="Urethral:groove"} +[Term] +id: UBERON:0013247 +name: male paramesonephric duct +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0012275 ! meso-epithelium +intersection_of: UBERON:0003914 ! epithelial tube +intersection_of: develops_from UBERON:0003890 ! Mullerian duct +intersection_of: part_of UBERON:0000079 ! male reproductive system +relationship: develops_from UBERON:0003890 ! Mullerian duct +relationship: part_of UBERON:0000079 ! male reproductive system + +[Term] +id: UBERON:0013279 +name: diaphysis of fibula +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0001446 ! fibula +relationship: part_of UBERON:0001446 ! fibula + +[Term] +id: UBERON:0013280 +name: diaphysis of tibia +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0000979 ! tibia +relationship: part_of UBERON:0000979 ! tibia + [Term] id: UBERON:0013399 name: blood vessel layer of choroid @@ -295583,6 +412144,7 @@ synonym: "vessel layer of choroid" EXACT [FMA:58435] xref: FMA:58435 is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010313 ! neural crest-derived structure +relationship: composed_primarily_of UBERON:0001981 ! blood vessel relationship: part_of UBERON:0001776 {source="FMA"} ! optic choroid property_value: UBPROP:0000001 "a layer of medium-diameter blood vessels of the choroid, a layer of the eye[Wikipedia:Sattler's_layer]." xsd:string {source="Wikipedia:Sattler's_layer"} @@ -295604,6 +412166,7 @@ xref: http://linkedlifedata.com/resource/umls/id/C0230041 xref: http://www.snomedbrowser.com/Codes/Details/264452006 xref: MA:0003061 xref: NCIT:C77638 +xref: neuronames:2806 xref: SCTID:264452006 xref: UMLS:C0230041 {source="ncithesaurus:Cranial_Cavity"} xref: Wikipedia:Cranial_cavity @@ -295615,6 +412178,23 @@ relationship: luminal_space_of UBERON:0003129 ! skull relationship: part_of UBERON:0003129 {source="Wikipedia"} ! skull property_value: depicted:by http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg xsd:anyURI +[Term] +id: UBERON:0013455 +name: spheno-petrosal fissure +is_a: UBERON:0006800 ! anatomical line +intersection_of: UBERON:0006800 ! anatomical line +intersection_of: connects UBERON:0001677 ! sphenoid bone +intersection_of: connects UBERON:0001694 ! petrous part of temporal bone +relationship: connects UBERON:0001677 ! sphenoid bone +relationship: connects UBERON:0001694 ! petrous part of temporal bone +relationship: part_of UBERON:0003129 ! skull + +[Term] +id: UBERON:0013472 +name: upper esophagus +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: part_of UBERON:0001043 ! esophagus + [Term] id: UBERON:0013475 name: gustatory gland @@ -295634,6 +412214,15 @@ relationship: part_of UBERON:0010033 ! posterior part of tongue property_value: UBPROP:0000009 "posterior deep lingual glands produce lingual lipase, which hydrolyzes triacylglycerols in the acidic gastric lumen, the first step in the digestion of dietary fat (Hamosh & Scow, 1973; Hamosh & Burns, 1977). In view of their close proximity to the lingual lymphatic tissues, the glands were also thought to be involved in antimicrobial action and local immune response (Nair & Schroeder, 1983)[PMCID:PMC2667924]" xsd:string property_value: UBPROP:0000010 "a group of tubulo-acinar serous glands located beneath the circumvallate and foliate papillae of the tongue and their ducts open into the trough at the base of the papillae. The saliva from posterior deep lingual glands is known to modulate the microenvironment at taste reception sites, and affect chemoreception (Gurkan & Bradley, 1988) and it is an important source of growth factors for taste receptor cells (Morris-Wiman et al. 2000)[PMCID:PMC2667924]" xsd:string +[Term] +id: UBERON:0013478 +name: cecal tonsil +is_a: UBERON:0001962 ! gut-associated lymphoid tissue +intersection_of: UBERON:0001961 ! mucosa-associated lymphoid tissue +intersection_of: part_of UBERON:0001153 ! caecum +relationship: only_in_taxon NCBITaxon:8782 ! Aves +relationship: part_of UBERON:0000314 ! cecum mucosa + [Term] id: UBERON:0013479 name: lung endothelium @@ -295688,6 +412277,71 @@ xref: FMA:269065 is_a: UBERON:0001241 ! crypt of Lieberkuhn of small intestine relationship: part_of UBERON:0008343 {source="FMA"} ! intestinal villus of jejunum +[Term] +id: UBERON:0013491 +name: cervical fascia +is_a: UBERON:0003568 ! neck connective tissue +is_a: UBERON:0008982 ! fascia +intersection_of: UBERON:0008982 ! fascia +intersection_of: part_of UBERON:0000974 ! neck + +[Term] +id: UBERON:0013493 +name: abdominal fascia +is_a: UBERON:0003567 ! abdomen connective tissue +is_a: UBERON:0008982 ! fascia +intersection_of: UBERON:0008982 ! fascia +intersection_of: part_of UBERON:0000916 ! abdomen + +[Term] +id: UBERON:0013498 +name: vestibulo-cochlear VIII ganglion complex +is_a: UBERON:0001714 ! cranial ganglion +intersection_of: UBERON:0001714 ! cranial ganglion +intersection_of: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve +relationship: extends_fibers_into UBERON:0001648 ! vestibulocochlear nerve + +[Term] +id: UBERON:0013501 +name: cloacal sphincter +namespace: uberon +def: "A sphincter muscle that is part of a cloaca." [OBOL:automatic] +comment: the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). +synonym: "sphincter cloacae" EXACT PLURAL [] +xref: NCIT:C34129 +xref: UMLS:C1516658 {source="ncithesaurus:Cloacal_Sphincter"} +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0014783 ! cloacal muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: part_of UBERON:0000162 ! cloaca + +[Term] +id: UBERON:0013502 +name: 5th arch mesenchyme +is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: part_of UBERON:0003116 ! pharyngeal arch 5 +relationship: part_of UBERON:0003116 ! pharyngeal arch 5 + +[Term] +id: UBERON:0013503 +name: caudal vertebra cartilage element +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0018142 ! caudal vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +relationship: develops_from UBERON:0013504 ! caudal vertebra pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0001095 ! caudal vertebra + +[Term] +id: UBERON:0013504 +name: caudal vertebra pre-cartilage condensation +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation + [Term] id: UBERON:0013505 name: cervical vertebra cartilage element @@ -295699,7 +412353,10 @@ is_a: UBERON:0003601 ! neck cartilage is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015007 ! cervical vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0013506 ! cervical vertebra pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002413 ! cervical vertebra [Term] id: UBERON:0013506 @@ -295708,6 +412365,8 @@ namespace: uberon def: "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0013507 @@ -295719,7 +412378,10 @@ xref: EHDAA2:0002014 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015008 ! thoracic vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0013508 ! thoracic vertebra pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002347 ! thoracic vertebra [Term] id: UBERON:0013508 @@ -295728,6 +412390,8 @@ namespace: uberon def: "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0013509 @@ -295739,7 +412403,10 @@ xref: EHDAA2:0001038 is_a: UBERON:0011094 ! vertebra cartilage element is_a: UBERON:0015009 ! lumbar vertebra endochondral element is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0013510 ! lumbar vertebra pre-cartilage condensation +relationship: has_potential_to_develop_into UBERON:0002414 ! lumbar vertebra [Term] id: UBERON:0013510 @@ -295748,6 +412415,8 @@ namespace: uberon def: "A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0011095 ! vertebra pre-cartilage condensation is_a: UBERON:0015009 ! lumbar vertebra endochondral element +intersection_of: UBERON:0015009 ! lumbar vertebra endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0013512 @@ -295784,7 +412453,10 @@ synonym: "zone of uterine tube" EXACT [FMA:18302] xref: FMA:18302 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube +intersection_of: UBERON:0013522 ! subdivision of tube +intersection_of: subdivision_of UBERON:0000993 ! oviduct relationship: part_of UBERON:0000993 ! oviduct +relationship: subdivision_of UBERON:0000993 ! oviduct property_value: UBPROP:0000012 "FMA class may only represent the uterine portion" xsd:string {external_ontology="FMA"} [Term] @@ -295816,24 +412488,16 @@ relationship: part_of UBERON:0011565 {source="FMA"} ! lumen of gastrointestinal property_value: UBPROP:0000001 "Organ cavity which is bound by the internal surface of the wall of stomach. Examples: There is only one cavity of stomach[FMA:14585]." xsd:string {source="FMA:14585"} [Term] -id: UBERON:0013529 -name: Brodmann area -namespace: uberon -def: "A segmentation of the cerebral cortex on the basis of cytoarchitecture as described in Brodmann-1905, Brodmann-1909 and Brodmann-10. Maps for several species were presented. NeuroNames includes only areas in the human and in Old World monkeys. Of the latter, Brodmann studied representatives of several species including guenons (one Cercopithecus mona, one Cercocebus torquatus, and one Cercopithecus otherwise unspecified), which are all closely related African species, and one macaque (Macaca mulatta) an Asian species (Brodmann-1905). The legend to the summary map in Brodmann-1909 ascribes the areas simply to Cercopithecus. Brodmann referenced the areas by name and number. The same area number in humans and monkeys did not necessarily refer to topologically or cytoarchitecturally homologous structures. In NeuroNames the standard term for human areas consists of the English translation of Brodmann's Latin name followed by the number he assigned, e.g., agranular frontal area 6; the standard terms for monkey areas are in the format: area 6 of Brodmann-1909. He mapped a portion of areas limited to the banks of sulci, e.g., area 3 of Brodmann-1909 (Brodmann-1909) onto the adjacent, visible surface. This accounts for the fact that some areas appear larger on his surface map than on maps of other authors, e.g., area 3 of Vogts-1919. (Adapted from NeuroNames)." [BIRNLEX:1731] -synonym: "Brodmann parcellation scheme region" RELATED [BIRNLEX:1731] -synonym: "Brodmann partition scheme region" RELATED [BIRNLEX:1731] -synonym: "Brodmann's areas" RELATED PLURAL [BIRNLEX:1731] -xref: BAMS:VTM -xref: BIRNLEX:1731 -xref: FMA:68596 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1032 {source="tgbugs"} -xref: NCIT:C94868 -xref: SCTID:384717008 -xref: Wikipedia:Brodmann_area -xref: WikipediaCategory:Brodmann_areas -is_a: UBERON:0002616 ! regional part of brain -is_a: UBERON:0010314 ! structure with developmental contribution from neural crest -relationship: part_of UBERON:0000956 {source="FMA", source="Wikipedia"} ! cerebral cortex +id: UBERON:0013526 +name: otocyst lumen +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +is_a: UBERON:0007473 ! lumen of epithelial sac +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0003051 ! ear vesicle +relationship: develops_from UBERON:0006273 ! otic pit +relationship: luminal_space_of UBERON:0003051 ! ear vesicle +relationship: part_of UBERON:0003051 ! ear vesicle [Term] id: UBERON:0013531 @@ -295849,8 +412513,8 @@ xref: BTO:0003977 xref: DHBA:10324 xref: DHBA:266441669 xref: DMBA:16093 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2436 xref: MBA:254 +xref: neuronames:2436 xref: Wikipedia:Retrosplenial_region is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -295864,6 +412528,8 @@ def: "A metapodium bone that is part of a digit 1 plus metapodial segment." [OBO synonym: "metapodium 1" EXACT [] synonym: "metapodium I" EXACT [] is_a: UBERON:0003821 ! metapodium bone +intersection_of: UBERON:0003821 ! metapodium bone +intersection_of: part_of UBERON:5006048 ! digit 1 plus metapodial segment relationship: part_of UBERON:5006048 ! digit 1 plus metapodial segment [Term] @@ -295907,6 +412573,8 @@ def: "A metapodium bone that is part of a digit 5 plus metapodial segment." [OBO synonym: "metapodium 5" EXACT [] synonym: "metapodium V" EXACT [] is_a: UBERON:0003821 ! metapodium bone +intersection_of: UBERON:0003821 ! metapodium bone +intersection_of: part_of UBERON:5006052 ! digit 5 plus metapodial segment relationship: part_of UBERON:5006052 ! digit 5 plus metapodial segment [Term] @@ -295955,7 +412623,32 @@ def: "Ossicle that develops within bands of dense, regular connective tissue (e. comment: Sesamoids are often endochondral replacement elements and in addition to bone tissue, may also be composed of articular cartilage, fibrocartilage, hyaline cartilage, and calcified cartilage. synonym: "sesamoid" EXACT [VSAO:0000137] xref: VSAO:0000137 +is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010911 {source="VSAO"} ! ossicle +relationship: develops_in UBERON:0007846 ! dense regular connective tissue +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata + +[Term] +id: UBERON:0013632 +name: sesamoid cartilage +is_a: UBERON:0007844 ! cartilage element +is_a: UBERON:0013631 ! sesamoid element +intersection_of: UBERON:0013631 ! sesamoid element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue + +[Term] +id: UBERON:0013636 +name: epithelium of intestinal villus +namespace: uberon +def: "An epithelium that is part of a intestinal villus." [OBOL:automatic] +synonym: "intestinal villus epithelium" EXACT [FMA:63587] +synonym: "villous epithelium" RELATED [] +synonym: "villus epithelium" RELATED [] +xref: FMA:63587 +is_a: UBERON:0001902 ! epithelium of small intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001213 ! intestinal villus +relationship: part_of UBERON:0001213 ! intestinal villus [Term] id: UBERON:0013637 @@ -295972,8 +412665,19 @@ xref: MA:0003125 xref: NCIT:C13092 is_a: UBERON:0001328 ! lobe of prostate is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001328 ! lobe of prostate +intersection_of: in_lateral_side_of UBERON:0002367 ! prostate gland +relationship: in_lateral_side_of UBERON:0002367 ! prostate gland property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI +[Term] +id: UBERON:0013645 +name: gular gland +is_a: UBERON:0003297 ! gland of integumental system +intersection_of: UBERON:0002530 ! gland +intersection_of: part_of UBERON:0011154 ! gular region +relationship: part_of UBERON:0011154 ! gular region + [Term] id: UBERON:0013678 name: anatomical line between inner canthi @@ -295985,7 +412689,6 @@ synonym: "inter medial canthal line" EXACT [] synonym: "inter-canthal line" BROAD [] synonym: "intercanthal line" BROAD [] xref: FMA:284806 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006800 ! anatomical line relationship: part_of UBERON:0001456 ! face @@ -295998,8 +412701,8 @@ synonym: "cranial conduit" NARROW [FMA:53165] synonym: "cranial foramen" NARROW [] synonym: "foramen of skull" EXACT [Wikipedia:Foramina_of_the_skull] synonym: "foramen of skull" EXACT [http://en.wikipedia.org/wiki/Foramina_of_the_skull] -synonym: "foramina of the skull" RELATED PLURAL [http://en.wikipedia.org/wiki/Foramina_of_the_skull] synonym: "foramina of the skull" RELATED PLURAL [Wikipedia:Foramina_of_the_skull] +synonym: "foramina of the skull" RELATED PLURAL [http://en.wikipedia.org/wiki/Foramina_of_the_skull] xref: FMA:53165 xref: http://en.wikipedia.org/wiki/Foramina_of_the_skull xref: http://www.snomedbrowser.com/Codes/Details/276742007 @@ -296024,6 +412727,22 @@ relationship: connects UBERON:0000464 {minCardinality="2", maxCardinality="2"} ! relationship: luminal_space_of UBERON:0004111 ! anatomical conduit relationship: part_of UBERON:0004111 ! anatomical conduit +[Term] +id: UBERON:0013687 +name: pericranium +is_a: UBERON:0002515 ! periosteum +intersection_of: UBERON:0002515 ! periosteum +intersection_of: part_of UBERON:0003129 ! skull +relationship: part_of UBERON:0003129 ! skull + +[Term] +id: UBERON:0013689 +name: appendix lymphoid tissue +is_a: UBERON:0001744 ! lymphoid tissue +intersection_of: UBERON:0001744 ! lymphoid tissue +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + [Term] id: UBERON:0013691 name: buttock @@ -296082,6 +412801,27 @@ is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0001155 ! colon +[Term] +id: UBERON:0013696 +name: tonsil epithelium +is_a: UBERON:0003351 ! pharyngeal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002372 ! tonsil +relationship: part_of UBERON:0002372 ! tonsil + +[Term] +id: UBERON:0013697 +name: exocrine pancreas epithelium +namespace: uberon +def: "Epithelium lining the exocrine pancreas." [CALOHA:TS-2108] +synonym: "epithelium of exocrine pancreas" RELATED [CALOHA:TS-2108] +synonym: "exocrine pancreas epithelial cell" RELATED [CALOHA:TS-2108] +xref: CALOHA:TS-2108 +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000017 ! exocrine pancreas +relationship: part_of UBERON:0000017 ! exocrine pancreas + [Term] id: UBERON:0013698 name: strand of pubic hair @@ -296107,6 +412847,8 @@ synonym: "hair of axilla" EXACT [FMA:54253] xref: FMA:54253 xref: SCTID:280911007 is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0009472 ! axilla relationship: part_of UBERON:0009472 ! axilla property_value: UBPROP:0000202 FMA:70756 @@ -296117,6 +412859,7 @@ namespace: uberon def: "Musculature of the head and neck, spine, and ribs." [HP:0003327] xref: EHDAA2:0000159 xref: EMAPA:18166 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: attaches_to UBERON:0005944 ! axial skeleton plus cranial skeleton @@ -296157,6 +412900,8 @@ def: "Anatomical projection that is part of the integumentl system." [http://orc synonym: "skin projection" NARROW [] is_a: UBERON:0004529 ! anatomical projection is_a: UBERON:0006003 ! integumentary adnexa +intersection_of: UBERON:0004529 ! anatomical projection +intersection_of: part_of UBERON:0002416 ! integumental system [Term] id: UBERON:0013704 @@ -296183,7 +412928,6 @@ def: "Fluid contained within the notochordal canal." [http://animaldiversity.org comment: Distinct feature of coelocanths synonym: "notochord fluid" EXACT [] synonym: "portion of notochordal fluid" EXACT [] -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid @@ -296213,6 +412957,8 @@ synonym: "metaphysis of ulna" EXACT [FMA:33767] xref: FMA:33767 is_a: UBERON:0001438 ! metaphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0001424 ! ulna relationship: part_of UBERON:0001010 {source="FMA"} ! diaphysis of ulna [Term] @@ -296226,6 +412972,8 @@ synonym: "humeral metaphysis" EXACT [FMA:32830] xref: FMA:32830 is_a: UBERON:0001438 ! metaphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0000976 ! humerus relationship: part_of UBERON:0000976 ! humerus [Term] @@ -296240,6 +412988,8 @@ xref: FMA:33135 xref: MA:0003106 is_a: UBERON:0001438 ! metaphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0000979 ! tibia relationship: part_of UBERON:0000979 ! tibia [Term] @@ -296252,8 +413002,19 @@ synonym: "radial metaphysis" EXACT [FMA:33789] xref: FMA:33789 is_a: UBERON:0001438 ! metaphysis is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0001423 ! radius bone relationship: part_of UBERON:0001423 ! radius bone +[Term] +id: UBERON:0013752 +name: diaphysis of metacarpal bone +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0002374 ! metacarpal bone +relationship: part_of UBERON:0002374 ! metacarpal bone + [Term] id: UBERON:0013753 name: distal epiphysis of metacarpal bone @@ -296267,6 +413028,8 @@ synonym: "lower end of metacarpal bone" EXACT [FMA:33798] xref: FMA:33798 is_a: UBERON:0004379 ! distal epiphysis is_a: UBERON:0004390 ! epiphysis of metacarpal bone +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0002374 ! metacarpal bone [Term] id: UBERON:0013754 @@ -296296,7 +413059,10 @@ synonym: "portion of arterial blood" EXACT [FMA:83066] xref: FMA:83066 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood +intersection_of: UBERON:0000178 ! blood +intersection_of: located_in UBERON:0001637 ! artery intersection_of: part_of UBERON:0001637 ! artery +relationship: located_in UBERON:0001637 ! artery relationship: part_of UBERON:0001637 ! artery [Term] @@ -296310,7 +413076,10 @@ synonym: "venous blood" EXACT [FMA:83067] xref: FMA:83067 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood +intersection_of: UBERON:0000178 ! blood +intersection_of: located_in UBERON:0001638 ! vein intersection_of: part_of UBERON:0001638 ! vein +relationship: located_in UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein [Term] @@ -296325,7 +413094,10 @@ xref: FMA:263901 xref: NCIT:C32212 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood +intersection_of: UBERON:0000178 ! blood +intersection_of: located_in UBERON:0001982 ! capillary intersection_of: part_of UBERON:0001982 ! capillary +relationship: located_in UBERON:0001982 ! capillary relationship: part_of UBERON:0001982 ! capillary [Term] @@ -296339,8 +413111,31 @@ xref: FMA:20422 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000161 ! orifice is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000161 ! orifice +intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix +[Term] +id: UBERON:0013760 +name: external cervical os +is_a: UBERON:0013758 ! cervical os +intersection_of: UBERON:0013758 ! cervical os +intersection_of: continuous_with UBERON:0000996 ! vagina +relationship: connects UBERON:0000002 ! uterine cervix +relationship: connects UBERON:0000996 ! vagina +relationship: continuous_with UBERON:0000996 ! vagina +relationship: part_of UBERON:0012249 ! ectocervix + +[Term] +id: UBERON:0013761 +name: cervical cavity +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002553 ! anatomical cavity +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: luminal_space_of UBERON:0000002 ! uterine cervix +relationship: luminal_space_of UBERON:0000002 ! uterine cervix + [Term] id: UBERON:0013763 name: obsolete sensory epithelium of spiral organ @@ -296447,6 +413242,8 @@ xref: FMA:17745 xref: Wikipedia:Uterine_cavity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] @@ -296455,17 +413252,45 @@ name: line connecting laterally paired nipples namespace: uberon def: "Line across midline connecting a left and right nipples." [http://orcid.org/0000-0002-6601-2165] synonym: "intermammary line" EXACT [] -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006800 ! anatomical line relationship: part_of UBERON:0002100 ! trunk property_value: UBPROP:0000008 "In mammals with multiple pairs of nipples, this line is only applicable for laterally homologous nipples" xsd:string +[Term] +id: UBERON:0013772 +name: left nipple +is_a: UBERON:0002030 ! nipple +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002030 ! nipple +intersection_of: in_left_side_of UBERON:0013702 ! body proper +relationship: in_left_side_of UBERON:0013702 ! body proper + +[Term] +id: UBERON:0013773 +name: right nipple +is_a: UBERON:0002030 ! nipple +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002030 ! nipple +intersection_of: in_right_side_of UBERON:0013702 ! body proper +relationship: in_right_side_of UBERON:0013702 ! body proper + +[Term] +id: UBERON:0013774 +name: diaphysis of metatarsal bone +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0004769 ! diaphysis +intersection_of: UBERON:0004769 ! diaphysis +intersection_of: part_of UBERON:0001448 ! metatarsal bone +relationship: part_of UBERON:0001448 ! metatarsal bone + [Term] id: UBERON:0013776 name: skin of palmar/plantar part of autopod namespace: uberon def: "A zone of skin that is part of a palmar/plantar part of autopod." [OBOL:automatic] is_a: UBERON:0015790 ! autopod skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0008837 ! palmar/plantar part of autopod relationship: part_of UBERON:0008837 ! palmar/plantar part of autopod [Term] @@ -296480,6 +413305,8 @@ xref: FMA:38301 xref: SCTID:181544004 is_a: UBERON:0001519 ! skin of manus is_a: UBERON:0013776 ! skin of palmar/plantar part of autopod +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0008878 ! palmar part of manus relationship: part_of UBERON:0008878 ! palmar part of manus [Term] @@ -296495,6 +413322,8 @@ xref: FMA:37849 xref: SCTID:181566006 is_a: UBERON:0001513 ! skin of pes is_a: UBERON:0013776 ! skin of palmar/plantar part of autopod +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0008338 ! plantar part of pes relationship: part_of UBERON:0008338 ! plantar part of pes [Term] @@ -296562,8 +413391,9 @@ id: UBERON:0014382 name: collection of hairs on head or neck namespace: uberon def: "A collection of hairs that is part of a craniocervical region." [OBOL:automatic] -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0010164 ! collection of hairs +intersection_of: UBERON:0010164 ! collection of hairs +intersection_of: part_of UBERON:0007811 ! craniocervical region relationship: part_of UBERON:0007811 ! craniocervical region [Term] @@ -296606,6 +413436,9 @@ synonym: "epithelium of renal collecting tubule" EXACT [] xref: EMAPA:37885 {source="MA:th"} is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0004211 ! nephron epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule +relationship: contributes_to_morphology_of UBERON:0001232 ! collecting duct of renal tubule relationship: part_of UBERON:0001232 ! collecting duct of renal tubule property_value: UBPROP:0000008 "In mouse, the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" xsd:string @@ -296619,7 +413452,6 @@ synonym: "gustatory papillae" RELATED PLURAL [] synonym: "taste papilla" EXACT [] synonym: "taste papillae" RELATED PLURAL [] xref: FMA:54822 -is_a: BFO:0000040 ! material entity is_a: UBERON:0001726 ! papilla of tongue intersection_of: UBERON:0001726 ! papilla of tongue intersection_of: has_part UBERON:0001727 ! taste bud @@ -296637,8 +413469,34 @@ synonym: "smooth muscle of ileum" RELATED [https://orcid.org/0000-0002-6601-2165 xref: BTO:0005574 xref: FMA:14958 is_a: UBERON:0011201 ! muscle layer of small intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0002116 ! ileum relationship: part_of UBERON:0002116 ! ileum +[Term] +id: UBERON:0014391 +name: palmar/plantar sweat gland +is_a: UBERON:0000423 ! eccrine sweat gland +intersection_of: UBERON:0001820 ! sweat gland +intersection_of: part_of UBERON:0008837 ! palmar/plantar part of autopod +relationship: part_of UBERON:0008837 ! palmar/plantar part of autopod + +[Term] +id: UBERON:0014392 +name: sweat of palm +is_a: UBERON:0001089 ! sweat +intersection_of: UBERON:0001089 ! sweat +intersection_of: produced_by UBERON:0014391 ! palmar/plantar sweat gland +relationship: produced_by UBERON:0014391 ! palmar/plantar sweat gland + +[Term] +id: UBERON:0014393 +name: sweat of axilla +is_a: UBERON:0001089 ! sweat +intersection_of: UBERON:0001089 ! sweat +intersection_of: produced_by UBERON:0018232 ! axillary sweat gland +relationship: produced_by UBERON:0018232 ! axillary sweat gland + [Term] id: UBERON:0014394 name: uterine fat pad @@ -296651,6 +413509,8 @@ synonym: "uterine fat depot" EXACT [] xref: EMAPA:37979 {source="MA:th"} is_a: UBERON:0003916 ! fat pad is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus [Term] @@ -296660,6 +413520,8 @@ namespace: uberon def: "A proximal mesopodial endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] is_a: UBERON:0003656 ! mesopodium bone is_a: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue relationship: develops_from UBERON:0017751 ! proximal mesopodial cartilage element [Term] @@ -296697,6 +413559,7 @@ name: respiratory muscle namespace: uberon def: "Muscle that is part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] subset: pheno_slim +xref: MESH:D012132 is_a: UBERON:0003831 ! respiratory system muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: capable_of_part_of GO:0007585 ! respiratory gaseous exchange by respiratory system @@ -296718,6 +413581,18 @@ intersection_of: luminal_space_of UBERON:0003909 ! sinusoid relationship: luminal_space_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid +[Term] +id: UBERON:0014400 +name: hepatic sinusoidal space +namespace: uberon +def: "A sinusoidal space that is part of a hepatic sinusoid." [OBOL:automatic] +synonym: "lumen of hepatic sinusoid" EXACT [FMA:262090] +xref: FMA:262090 +is_a: UBERON:0014399 ! sinusoidal space +intersection_of: UBERON:0014399 ! sinusoidal space +intersection_of: part_of UBERON:0001281 ! hepatic sinusoid +relationship: part_of UBERON:0001281 ! hepatic sinusoid + [Term] id: UBERON:0014401 name: renal venous blood vessel @@ -296750,6 +413625,14 @@ intersection_of: UBERON:0000061 ! anatomical structure intersection_of: output_of GO:0007548 ! sex differentiation relationship: output_of GO:0007548 ! sex differentiation +[Term] +id: UBERON:0014403 +name: male anatomical structure +is_a: UBERON:0014402 ! sex-specific anatomical structure +intersection_of: UBERON:0014402 ! sex-specific anatomical structure +intersection_of: part_of UBERON:0003101 ! male organism +relationship: part_of UBERON:0003101 ! male organism + [Term] id: UBERON:0014404 name: female anatomical structure @@ -296861,7 +413744,7 @@ xref: DHBA:12182 xref: EMAPA:37919 {source="MA:th"} xref: FMA:72401 xref: HBA:9083 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=468 {source="BIRNLEX:864"} +xref: neuronames:468 {source="BIRNLEX:864"} xref: SCTID:416164009 xref: UMLS:C0175358 {source="BIRNLEX:864"} is_a: UBERON:0002308 ! nucleus of brain @@ -296899,6 +413782,15 @@ is_a: UBERON:0003357 ! epithelium of tongue intersection_of: UBERON:0002926 ! gustatory epithelium intersection_of: part_of UBERON:0001723 ! tongue +[Term] +id: UBERON:0014453 +name: gustatory epithelium of palate +is_a: UBERON:0002424 ! oral epithelium +is_a: UBERON:0002926 ! gustatory epithelium +intersection_of: UBERON:0002926 ! gustatory epithelium +intersection_of: part_of UBERON:0007375 ! roof of mouth +relationship: part_of UBERON:0007375 ! roof of mouth + [Term] id: UBERON:0014454 name: visceral abdominal adipose tissue @@ -296954,6 +413846,9 @@ xref: EMAPA:36644 xref: FMA:77582 xref: SCTID:57098005 is_a: UBERON:0001808 ! parasympathetic ganglion +intersection_of: UBERON:0001808 ! parasympathetic ganglion +intersection_of: extends_fibers_into UBERON:0002008 ! cardiac nerve plexus +relationship: extends_fibers_into UBERON:0002008 ! cardiac nerve plexus property_value: UBPROP:0000001 "Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery[http://medical-dictionary.thefreedictionary.com/cardiac+ganglion]." xsd:string {source="http://medical-dictionary.thefreedictionary.com/cardiac+ganglion"} [Term] @@ -296964,6 +413859,8 @@ def: "Encapsulated adipose tissue associated with the kidney." [MP:0008902] subset: pheno_slim synonym: "perirenal fat pad" RELATED [MP:0008902] is_a: UBERON:0003427 ! abdominal fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney [Term] @@ -297006,6 +413903,8 @@ xref: FMA:265719 xref: TAO:0002100 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: composed_primarily_of UBERON:0015019 ! rib endochondral element +relationship: has_part UBERON:0003252 ! thoracic rib cage relationship: part_of UBERON:0011138 ! postcranial axial skeletal system property_value: RO:0002161 NCBITaxon:7778 {source="Wikipedia"} @@ -297020,6 +413919,8 @@ synonym: "distal phalanx of digit I" EXACT COMPARATIVE_PREFERRED [https://github synonym: "distal phalanx of first digit" EXACT [] synonym: "first distal phalanx" RELATED [] is_a: UBERON:0004300 ! distal phalanx +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0006048 ! digit 1 relationship: part_of UBERON:0006048 ! digit 1 relationship: part_of UBERON:5106048 ! digit 1 digitopodial skeleton @@ -297109,6 +414010,8 @@ synonym: "distal phalanx of little digit" EXACT [] synonym: "fifth digit distal phalanx" EXACT [] synonym: "fifth distal phalanx" EXACT [] is_a: UBERON:0004300 ! distal phalanx +intersection_of: UBERON:0004300 ! distal phalanx +intersection_of: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:5106052 ! digit 5 digitopodial skeleton @@ -297216,6 +414119,8 @@ synonym: "middle phalanx of digit V" EXACT COMPARATIVE_PREFERRED [https://github synonym: "middle phalanx of fifth digit" EXACT [] synonym: "middle phalanx of little digit" EXACT [] is_a: UBERON:0004301 ! middle phalanx +intersection_of: UBERON:0004301 ! middle phalanx +intersection_of: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:5106052 ! digit 5 digitopodial skeleton @@ -297230,6 +414135,8 @@ synonym: "first proximal phalanx of autopod" EXACT [] synonym: "proximal phalanx of digit I" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] synonym: "proximal phalanx of first digit of autopod" EXACT [] is_a: UBERON:0004302 ! proximal phalanx +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0006048 ! digit 1 relationship: part_of UBERON:0006048 ! digit 1 relationship: part_of UBERON:5106048 ! digit 1 digitopodial skeleton @@ -297320,6 +414227,8 @@ synonym: "proximal phalanx of fifth digit" EXACT [] synonym: "proximal phalanx of fifth digit of autopod" EXACT [] synonym: "proximal phalanx of little digit" EXACT [] is_a: UBERON:0004302 ! proximal phalanx +intersection_of: UBERON:0004302 ! proximal phalanx +intersection_of: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:0006052 ! digit 5 relationship: part_of UBERON:5106052 ! digit 5 digitopodial skeleton @@ -297370,7 +414279,27 @@ synonym: "regional part of spinal cord central canal" EXACT HUMAN_PREFERRED [BIR xref: BIRNLEX:717 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: subdivision_of UBERON:0002291 ! central canal of spinal cord relationship: part_of UBERON:0002291 ! central canal of spinal cord +relationship: subdivision_of UBERON:0002291 ! central canal of spinal cord + +[Term] +id: UBERON:0014540 +name: white matter lamina of cerebellum +is_a: UBERON:0014530 ! white matter lamina of neuraxis +intersection_of: UBERON:0014530 ! white matter lamina of neuraxis +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: immediately_deep_to UBERON:0002956 ! granular layer of cerebellar cortex +relationship: part_of UBERON:0002037 ! cerebellum + +[Term] +id: UBERON:0014541 +name: thoracic division of spinal cord central canal +is_a: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: subdivision_of UBERON:0003038 ! thoracic spinal cord +relationship: subdivision_of UBERON:0003038 ! thoracic spinal cord [Term] id: UBERON:0014542 @@ -297383,6 +414312,9 @@ xref: FMA:321590 xref: SCTID:280403009 xref: UMLS:C0228620 {source="BIRNLEX:1511"} is_a: UBERON:0014538 {source="NIFSTD"} ! subdivision of spinal cord central canal +intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: subdivision_of UBERON:0002726 ! cervical spinal cord +relationship: subdivision_of UBERON:0002726 ! cervical spinal cord [Term] id: UBERON:0014543 @@ -297395,6 +414327,17 @@ xref: FMA:321589 xref: SCTID:280406001 xref: UMLS:C0228644 {source="BIRNLEX:1604"} is_a: UBERON:0014538 {source="NIFSTD"} ! subdivision of spinal cord central canal +intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: subdivision_of UBERON:0002792 ! lumbar spinal cord +relationship: subdivision_of UBERON:0002792 ! lumbar spinal cord + +[Term] +id: UBERON:0014547 +name: sacral division of spinal cord central canal +is_a: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: UBERON:0014538 ! subdivision of spinal cord central canal +intersection_of: subdivision_of UBERON:0005843 ! sacral spinal cord +relationship: subdivision_of UBERON:0005843 ! sacral spinal cord [Term] id: UBERON:0014610 @@ -297523,7 +414466,7 @@ synonym: "cerebrocerebellum" RELATED INCONSISTENT [MP:0009965] synonym: "neocerebellum" EXACT [] synonym: "pontocerebellum" EXACT [] xref: DHBA:12390 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2128 +xref: neuronames:2128 xref: Wikipedia:Cerebellum is_a: UBERON:0002749 ! regional part of cerebellar cortex relationship: part_of UBERON:0002245 ! cerebellar hemisphere @@ -297540,7 +414483,7 @@ synonym: "hemispherium lobus posterior" EXACT LATIN [FMA:72256, FMA:TA] xref: BAMS:HPL xref: FMA:72256 xref: HBA:12936 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=664 +xref: neuronames:664 xref: NLXANAT:20081261 is_a: UBERON:0002749 ! regional part of cerebellar cortex relationship: part_of UBERON:0002245 ! cerebellar hemisphere @@ -297559,20 +414502,95 @@ xref: BAMS:mw xref: BIRNLEX:1024 xref: BIRNLEX:1414 xref: FMA:83944 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=778 +xref: neuronames:778 is_a: UBERON:0014891 ! brainstem white matter is_a: UBERON:0019262 ! white matter of myelencephalon intersection_of: UBERON:0002316 ! white matter intersection_of: part_of UBERON:0001896 ! medulla oblongata relationship: part_of UBERON:0001896 ! medulla oblongata +[Term] +id: UBERON:0014671 +name: distal interphalangeal joint of manural digit 5 +is_a: UBERON:0007732 ! interphalangeal joint of manual digit 5 +is_a: UBERON:0014680 ! distal interphalangeal joint of digit 5 +intersection_of: UBERON:0009768 ! distal interphalangeal joint +intersection_of: part_of UBERON:0003625 ! manual digit 5 + +[Term] +id: UBERON:0014675 +name: distal interphalangeal joint of pedal digit 5 +is_a: UBERON:0007728 ! interphalangeal joint of pedal digit 5 +is_a: UBERON:0014680 ! distal interphalangeal joint of digit 5 +intersection_of: UBERON:0009768 ! distal interphalangeal joint +intersection_of: part_of UBERON:0003635 ! pedal digit 5 + +[Term] +id: UBERON:0014680 +name: distal interphalangeal joint of digit 5 +is_a: UBERON:0009768 ! distal interphalangeal joint +intersection_of: UBERON:0009768 ! distal interphalangeal joint +intersection_of: part_of UBERON:0006052 ! digit 5 +relationship: part_of UBERON:0006052 ! digit 5 + +[Term] +id: UBERON:0014686 +name: angular vein +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0009141 ! craniocervical region vein +relationship: tributary_of UBERON:0001653 ! facial vein + [Term] id: UBERON:0014693 name: inferior alveolar artery namespace: uberon +subset: human_reference_atlas xref: FMA:49695 xref: SCTID:276151008 is_a: UBERON:0009654 ! alveolar artery +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014695 +name: deep auricular artery +is_a: UBERON:0009655 ! auricular artery +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0009655 ! auricular artery +intersection_of: part_of UBERON:0035551 ! deep vasculature +relationship: branching_part_of UBERON:0001616 ! maxillary artery +relationship: part_of UBERON:0035551 ! deep vasculature +relationship: supplies UBERON:0010069 ! outer epithelial layer of tympanic membrane + +[Term] +id: UBERON:0014699 +name: extraembryonic venous system +is_a: UBERON:0004582 ! venous system +is_a: UBERON:0014701 ! extraembryonic vascular system +intersection_of: UBERON:0004582 ! venous system +intersection_of: overlaps UBERON:0002331 ! umbilical cord +intersection_of: part_of UBERON:0016887 ! entire extraembryonic component + +[Term] +id: UBERON:0014701 +name: extraembryonic vascular system +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0007798 ! vascular system +intersection_of: UBERON:0007798 ! vascular system +intersection_of: overlaps UBERON:0002331 ! umbilical cord +intersection_of: part_of UBERON:0016887 ! entire extraembryonic component +relationship: overlaps UBERON:0002331 ! umbilical cord +relationship: part_of UBERON:0016887 ! entire extraembryonic component + +[Term] +id: UBERON:0014702 +name: frontonasal process epithelium +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0004066 ! frontonasal prominence +relationship: develops_from UBERON:0000076 ! external ectoderm +relationship: part_of UBERON:0004066 ! frontonasal prominence [Term] id: UBERON:0014703 @@ -297622,16 +414640,29 @@ intersection_of: part_of UBERON:0006756 ! median lingual swelling relationship: develops_from UBERON:0013156 {source="EHDAA2"} ! 1st arch mandibular endoderm relationship: part_of UBERON:0006756 ! median lingual swelling +[Term] +id: UBERON:0014706 +name: primitive renal collecting duct system +is_a: UBERON:0007501 ! arborizing epithelial duct system +is_a: UBERON:0012275 ! meso-epithelium +relationship: develops_from UBERON:0000084 ! ureteric bud + [Term] id: UBERON:0014716 name: interlobular duct namespace: uberon def: "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." [ncithesaurus:Interlobular_Duct] +subset: human_reference_atlas xref: NCIT:C32828 xref: UMLS:C1512857 xref: Wikipedia:Interlobular_ducts is_a: UBERON:0035050 ! excretory duct +intersection_of: UBERON:0000058 ! duct +intersection_of: connected_to UBERON:0009911 ! lobule +intersection_of: part_of UBERON:0002384 ! connective tissue +relationship: connected_to UBERON:0009911 ! lobule relationship: part_of UBERON:0002384 ! connective tissue +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014717 @@ -297644,8 +414675,63 @@ xref: FMA:86278 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: part_of UBERON:0000414 ! mucous gland +relationship: composed_primarily_of CL:0000319 ! mucus secreting cell relationship: part_of UBERON:0000414 ! mucous gland +[Term] +id: UBERON:0014719 +name: intralobular duct +namespace: uberon +def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." [http://www.siumed.edu/~dking2/intro/glands.htm] +subset: human_reference_atlas +synonym: "intralobular ductule" RELATED [] +xref: SCTID:205214009 +is_a: UBERON:0000058 ! duct +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0009911 ! lobule +relationship: part_of UBERON:0009911 ! lobule +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014720 +name: interlobar duct +namespace: uberon +def: "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." [http://www.siumed.edu/~dking2/intro/glands.htm] +synonym: "intralobular ductule" RELATED [] +is_a: UBERON:0035050 ! excretory duct +intersection_of: UBERON:0000058 ! duct +intersection_of: connects UBERON:0009912 ! anatomical lobe +intersection_of: part_of UBERON:0002384 ! connective tissue +relationship: connects UBERON:0009912 ! anatomical lobe +relationship: part_of UBERON:0002384 ! connective tissue + +[Term] +id: UBERON:0014768 +name: superior palpebral vein +is_a: UBERON:0014769 ! palpebral vein +intersection_of: UBERON:0014769 ! palpebral vein +intersection_of: drains UBERON:0001712 ! upper eyelid +relationship: drains UBERON:0001712 ! upper eyelid + +[Term] +id: UBERON:0014769 +name: palpebral vein +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0009141 ! craniocervical region vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001711 ! eyelid +relationship: drains UBERON:0001711 ! eyelid +relationship: tributary_of UBERON:0014686 ! angular vein + +[Term] +id: UBERON:0014770 +name: palpebral artery +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003496 ! head blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001711 ! eyelid +relationship: supplies UBERON:0001711 ! eyelid + [Term] id: UBERON:0014775 name: prosomere @@ -297697,6 +414783,15 @@ intersection_of: UBERON:0004731 ! neuromere intersection_of: part_of UBERON:0006241 ! future spinal cord relationship: part_of UBERON:0006241 ! future spinal cord +[Term] +id: UBERON:0014780 +name: palatine aponeurosis +is_a: UBERON:0006614 ! aponeurosis +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0006614 ! aponeurosis +intersection_of: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0001733 ! soft palate + [Term] id: UBERON:0014783 name: cloacal muscle @@ -297738,6 +414833,8 @@ synonym: "musculature of arm" RELATED INCONSISTENT [FMA:50202] synonym: "set of muscles of arm" RELATED INCONSISTENT [FMA:50202] xref: FMA:50202 is_a: UBERON:0004474 ! musculature of arm +intersection_of: UBERON:0001015 ! musculature +intersection_of: part_of UBERON:0003822 ! forelimb stylopod relationship: part_of UBERON:0003822 ! forelimb stylopod [Term] @@ -297780,6 +414877,8 @@ name: pectoral appendage muscle namespace: uberon def: "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." [OBOL:automatic] is_a: UBERON:0010891 ! pectoral complex muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0004710 ! pectoral appendage relationship: part_of UBERON:0007269 {source="prolog"} ! pectoral appendage musculature [Term] @@ -297788,6 +414887,8 @@ name: pelvic appendage muscle namespace: uberon def: "Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin)." [OBOL:automatic] is_a: UBERON:0010890 ! pelvic complex muscle +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: part_of UBERON:0004709 ! pelvic appendage relationship: part_of UBERON:0007270 {source="prolog"} ! pelvic appendage musculature [Term] @@ -297809,7 +414910,9 @@ synonym: "tendon of Zinn" RELATED [Wikipedia:Annulus_of_Zinn] xref: FMA:49071 xref: Wikipedia:Annulus_of_Zinn is_a: UBERON:0000481 ! multi-tissue structure +relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata relationship: part_of UBERON:0004088 ! orbital region +relationship: surrounds UBERON:0000941 ! cranial nerve II [Term] id: UBERON:0014849 @@ -297829,6 +414932,8 @@ def: "Chorda tendinea which is attached to the leaflet of mitral valve and is co subset: pheno_slim xref: FMA:9349 is_a: UBERON:0005994 ! chorda tendineae +intersection_of: UBERON:0005994 ! chorda tendineae +intersection_of: part_of UBERON:0002084 ! heart left ventricle relationship: part_of UBERON:0002084 ! heart left ventricle [Term] @@ -297839,8 +414944,68 @@ def: "Chorda tendinea which is attached to the leaflet of tricuspid valve and is subset: pheno_slim xref: FMA:9300 is_a: UBERON:0005994 ! chorda tendineae +intersection_of: UBERON:0005994 ! chorda tendineae +intersection_of: part_of UBERON:0002080 ! heart right ventricle relationship: part_of UBERON:0002080 ! heart right ventricle +[Term] +id: UBERON:0014871 +name: distal epiphysis of distal phalanx of pedal digit 1 +is_a: UBERON:0014876 ! distal epiphysis of distal phalanx of pedal digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0004315 ! distal phalanx of pedal digit 1 +relationship: part_of UBERON:0004315 ! distal phalanx of pedal digit 1 + +[Term] +id: UBERON:0014875 +name: distal epiphysis of distal phalanx of pedal digit 5 +is_a: UBERON:0014876 ! distal epiphysis of distal phalanx of pedal digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0004319 ! distal phalanx of pedal digit 5 +relationship: part_of UBERON:0004319 ! distal phalanx of pedal digit 5 + +[Term] +id: UBERON:0014876 +name: distal epiphysis of distal phalanx of pedal digit +is_a: UBERON:0011976 ! epiphysis of distal phalanx of pes +is_a: UBERON:0013122 ! distal epiphysis of phalanx of pes +is_a: UBERON:0014887 ! distal epiphysis of distal phalanx of digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0003867 ! distal phalanx of pes + +[Term] +id: UBERON:0014881 +name: distal epiphysis of distal phalanx of manual digit 1 +is_a: UBERON:0014886 ! distal epiphysis of distal phalanx of manual digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0004337 ! distal phalanx of manual digit 1 +relationship: part_of UBERON:0004337 ! distal phalanx of manual digit 1 + +[Term] +id: UBERON:0014885 +name: distal epiphysis of distal phalanx of manual digit 5 +is_a: UBERON:0014886 ! distal epiphysis of distal phalanx of manual digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0004314 ! distal phalanx of manual digit 5 +relationship: part_of UBERON:0004314 ! distal phalanx of manual digit 5 + +[Term] +id: UBERON:0014886 +name: distal epiphysis of distal phalanx of manual digit +is_a: UBERON:0004409 ! distal epiphysis of phalanx of manus +is_a: UBERON:0011979 ! epiphysis of distal phalanx of manus +is_a: UBERON:0014887 ! distal epiphysis of distal phalanx of digit +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0003865 ! distal phalanx of manus + +[Term] +id: UBERON:0014887 +name: distal epiphysis of distal phalanx of digit +is_a: UBERON:0004448 ! distal epiphysis of phalanx +intersection_of: UBERON:0004379 ! distal epiphysis +intersection_of: part_of UBERON:0004300 ! distal phalanx +relationship: part_of UBERON:0004300 ! distal phalanx + [Term] id: UBERON:0014891 name: brainstem white matter @@ -297954,8 +415119,8 @@ synonym: "nervus facialis (genu)" RELATED LATIN [NeuroNames:581] xref: DHBA:12738 xref: EMAPA:37870 {source="MA:th"} xref: FMA:72510 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=581 xref: MBA:1116 +xref: neuronames:581 is_a: UBERON:0007702 {source="FMA"} ! tract of brain relationship: part_of UBERON:0003023 {source="FMA"} ! pontine tegmentum @@ -297970,12 +415135,25 @@ synonym: "retrosplenial granular area" RELATED [NeuroNames:1802] synonym: "retrosplenial granular cortex" RELATED [NeuroNames:1802] synonym: "ventral part of the retrosplenial area" RELATED [NeuroNames:1802] xref: EMAPA:37947 {source="MA:th"} -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1802 xref: MBA:886 +xref: neuronames:1802 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: part_of UBERON:0013531 ! retrosplenial region +[Term] +id: UBERON:0014930 +name: perivascular space +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: adjacent_to UBERON:0001981 ! blood vessel +intersection_of: adjacent_to UBERON:0002361 ! pia mater +relationship: adjacent_to UBERON:0001981 ! blood vessel +relationship: adjacent_to UBERON:0002361 ! pia mater +relationship: contains UBERON:0001359 ! cerebrospinal fluid +relationship: part_of UBERON:0010743 ! meningeal cluster + [Term] id: UBERON:0014950 name: layer of developing cerebral cortex @@ -297993,6 +415171,9 @@ def: "The major preaxial endrochondral skeletal element in the anterior zeugopod synonym: "radius element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "radius skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element +union_of: UBERON:0001423 ! radius bone +union_of: UBERON:0006286 ! radius cartilage element +union_of: UBERON:0010846 ! radius pre-cartilage condensation relationship: part_of UBERON:0010703 ! forelimb zeugopod skeleton [Term] @@ -298003,6 +415184,9 @@ def: "A radius-ulna bone or its cartilage or pre-cartilage precursor." [https:// synonym: "radius-ulna element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "radius-ulna skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element +union_of: UBERON:0006287 ! radius-ulna pre-cartilage condensation +union_of: UBERON:0006715 ! radio-ulna +union_of: UBERON:0010848 ! radius-ulna cartilage element relationship: part_of UBERON:0010703 ! forelimb zeugopod skeleton [Term] @@ -298014,6 +415198,9 @@ comment: The corresponding element in the posterior fin/limb is the fibula. synonym: "ulna element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "ulna skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element +union_of: UBERON:0001424 ! ulna +union_of: UBERON:0006306 ! ulna cartilage element +union_of: UBERON:0010847 ! ulna pre-cartilage condensation relationship: part_of UBERON:0010703 ! forelimb zeugopod skeleton [Term] @@ -298024,6 +415211,9 @@ def: "The major preaxial endochondral element in the posterior zeugopod[Phenosca synonym: "tibia element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "tibia skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element +union_of: UBERON:0000979 ! tibia +union_of: UBERON:0010849 ! tibia cartilage element +union_of: UBERON:0010850 ! tibia pre-cartilage condensation relationship: part_of UBERON:0010720 ! hindlimb zeugopod skeleton [Term] @@ -298035,6 +415225,11 @@ synonym: "cervical vertebra element" EXACT [https://github.com/obophenotype/uber synonym: "cervical vertebra skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: part_of UBERON:0006072 ! cervical region of vertebral column +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0013505 ! cervical vertebra cartilage element +union_of: UBERON:0013506 ! cervical vertebra pre-cartilage condensation relationship: part_of UBERON:0006072 ! cervical region of vertebral column [Term] @@ -298047,6 +415242,11 @@ synonym: "thoracic vertebra skeletal element" BROAD [https://github.com/obopheno is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: part_of UBERON:0006073 ! thoracic region of vertebral column +union_of: UBERON:0002347 ! thoracic vertebra +union_of: UBERON:0013507 ! thoracic vertebra cartilage element +union_of: UBERON:0013508 ! thoracic vertebra pre-cartilage condensation relationship: part_of UBERON:0006073 ! thoracic region of vertebral column [Term] @@ -298059,6 +415259,11 @@ synonym: "lumbar vertebra skeletal element" BROAD [https://github.com/obophenoty is_a: UBERON:0005173 ! abdominal segment element is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: part_of UBERON:0006074 ! lumbar region of vertebral column +union_of: UBERON:0002414 ! lumbar vertebra +union_of: UBERON:0013509 ! lumbar vertebra cartilage element +union_of: UBERON:0013510 ! lumbar vertebra pre-cartilage condensation relationship: part_of UBERON:0006074 ! lumbar region of vertebral column [Term] @@ -298071,6 +415276,11 @@ synonym: "sacral vertebra skeletal element" BROAD [https://github.com/obophenoty is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: part_of UBERON:0006075 ! sacral region of vertebral column +union_of: UBERON:0001094 ! sacral vertebra +union_of: UBERON:0010744 ! sacral vertebra pre-cartilage condensation +union_of: UBERON:0010745 ! sacral vertebra cartilage element relationship: part_of UBERON:0006075 ! sacral region of vertebral column [Term] @@ -298092,6 +415302,9 @@ def: "The major postaxial endochondral element in the posterior zeugopod[Phenosc synonym: "fibula element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "fibula skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element +union_of: UBERON:0001446 ! fibula +union_of: UBERON:0010851 ! fibula cartilage element +union_of: UBERON:0010852 ! fibula pre-cartilage condensation relationship: part_of UBERON:0010720 ! hindlimb zeugopod skeleton [Term] @@ -298102,6 +415315,9 @@ def: "A calcaneum bone or its cartilage or pre-cartilage precursor." [https://gi synonym: "calcaneum element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "calcaneum skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015050 ! tarsus endochondral element +union_of: UBERON:0001450 ! calcaneus +union_of: UBERON:0010801 ! calcaneum pre-cartilage condensation +union_of: UBERON:0010842 ! calcaneum cartilage element [Term] id: UBERON:0015015 @@ -298153,6 +415369,9 @@ synonym: "rib element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeli synonym: "rib skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0002228 ! rib +union_of: UBERON:0006288 ! rib cartilage element +union_of: UBERON:0006289 ! rib pre-cartilage condensation relationship: part_of UBERON:0014478 ! rib skeletal system property_value: UBPROP:0000008 "Humans have 24 ribs (12 pairs). The first seven sets of ribs, known as 'true ribs', are directly attached to the sternum through the costal cartilage. The following five sets are known as 'false ribs', three of these sharing a common cartilaginous connection to the sternum, while the last two (eleventh and twelfth ribs) are termed floating ribs (costae fluitantes) or vertebral ribs. They are attached to the vertebrae only, and not to the sternum or cartilage coming off of the sternum. Some people are missing one of the two pairs of floating ribs, while others have a third pair. Rib removal is the surgical excision of ribs for therapeutic or cosmetic reasons. In fish, there are often two sets of ribs attached to the vertebral column. One set, the dorsal ribs, are found in the dividing septum between the upper and lower parts of the main muscle segments, projecting roughly sideways from the vertebral column. The second set, of ventral ribs arise from the vertebral column just below the dorsal ribs, and enclose the lower body, often joining at the tips. Not all species possess both types of rib, with the dorsal ribs being most commonly absent. Sharks, for example, have no dorsal ribs, and only very short ventral ribs, while lampreys have no ribs at all. In some teleosts, there may be additional rib-like bones within the muscle mass. Tetrapods, however, only ever have a single set of ribs which are probably homologous with the dorsal ribs of fishes. In the early tetrapods, every vertebra bore a pair of ribs, although those on the thoracic vertebrae are typically the longest. The sacral ribs were stout and short, since they formed part of the pelvis, connecting the backbone to the hip bones.[1] In most subsequent forms, many of these early ribs have been lost, and in living amphibians and reptiles, there is great variation in rib structure and number. For example, turtles have only eight pairs of ribs, which are developed into a bony or cartilagenous carapace and plastron, while snakes have numerous ribs running along the full length of their trunk. Frogs typically have no ribs, aside from a sacral pair, which form part of the pelvis.[1]. In birds, ribs are present as distinct bones only on the thoracic region, although small fused ribs are present on the cervical vertebrae. The thoracic ribs of birds possess a wide projection to the rear; this uncinate process is an attachment for the shoulder muscles.[1]. Mammals usually also only have distinct ribs on the thoracic vertebra, although fixed cervical ribs are also present in monotremes. In marsupials and placental mammals, the cervical and lumbar ribs are found only as tiny remnants fused to the vertebrae, where they are referred to as transverse processes. In general, the structure and number of the true ribs in humans is similar to that in other mammals. Unlike reptiles, caudal ribs are never found in mammals." xsd:string @@ -298192,6 +415411,9 @@ def: "A phalanx bone or its cartilage or pre-cartilage precursor." [https://gith synonym: "phalanx element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015063 ! autopod endochondral element +union_of: UBERON:0003221 ! phalanx +union_of: UBERON:0010700 ! phalanx pre-cartilage condensation +union_of: UBERON:0010701 ! phalanx cartilage element relationship: part_of UBERON:0002544 ! digit relationship: part_of UBERON:0012150 ! skeleton of digitopodium @@ -298204,6 +415426,11 @@ synonym: "manual digit phalanx element" EXACT [https://github.com/obophenotype/u synonym: "manual digit phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015023 ! phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0002389 ! manual digit +union_of: UBERON:0001436 ! phalanx of manus +union_of: UBERON:0010586 ! manual digit phalanx pre-cartilage condensation +union_of: UBERON:0010686 ! manual digit phalanx cartilage element relationship: part_of UBERON:0002389 ! manual digit relationship: part_of UBERON:0010688 ! skeleton of manual acropodium relationship: part_of UBERON:5102389 ! manual digit digitopodial skeleton @@ -298217,6 +415444,11 @@ synonym: "manual digit 1 phalanx element" EXACT [https://github.com/obophenotype synonym: "manual digit 1 phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit I phalanx endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0001463 ! manual digit 1 +union_of: UBERON:0003620 ! manual digit 1 phalanx +union_of: UBERON:0010575 ! manual digit 1 phalanx pre-cartilage condensation +union_of: UBERON:0010675 ! manual digit 1 phalanx cartilage element relationship: part_of UBERON:0001463 ! manual digit 1 relationship: part_of UBERON:5101463 ! manual digit 1 digitopodial skeleton @@ -298265,6 +415497,11 @@ synonym: "manual digit 5 phalanx element" EXACT [https://github.com/obophenotype synonym: "manual digit 5 phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit V phalanx endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015024 ! manual digit phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0003625 ! manual digit 5 +union_of: UBERON:0003639 ! manual digit 5 phalanx +union_of: UBERON:0010579 ! manual digit 5 phalanx pre-cartilage condensation +union_of: UBERON:0010679 ! manual digit 5 phalanx cartilage element relationship: part_of UBERON:0003625 ! manual digit 5 relationship: part_of UBERON:5103625 ! manual digit 5 digitopodial skeleton @@ -298277,6 +415514,11 @@ synonym: "pedal digit phalanx element" EXACT [https://github.com/obophenotype/ub synonym: "pedal digit phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015023 ! phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0001466 ! pedal digit +union_of: UBERON:0001449 ! phalanx of pes +union_of: UBERON:0010585 ! pedal digit phalanx pre-cartilage condensation +union_of: UBERON:0010685 ! pedal digit phalanx cartilage element relationship: part_of UBERON:0001466 ! pedal digit relationship: part_of UBERON:0010696 ! skeleton of pedal acropodium relationship: part_of UBERON:5101466 ! pedal digit digitopodial skeleton @@ -298290,6 +415532,11 @@ synonym: "pedal digit 1 phalanx element" EXACT [https://github.com/obophenotype/ synonym: "pedal digit 1 phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit I phalanx endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0003631 ! pedal digit 1 +union_of: UBERON:0003640 ! pedal digit 1 phalanx +union_of: UBERON:0010580 ! pedal digit 1 phalanx pre-cartilage condensation +union_of: UBERON:0010680 ! pedal digit 1 phalanx cartilage element relationship: part_of UBERON:0003631 ! pedal digit 1 relationship: part_of UBERON:5103631 ! pedal digit 1 digitopodial skeleton @@ -298338,6 +415585,11 @@ synonym: "pedal digit 5 phalanx element" EXACT [https://github.com/obophenotype/ synonym: "pedal digit 5 phalanx skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit V phalanx endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015030 ! pedal digit phalanx endochondral element +intersection_of: UBERON:0015023 ! phalanx endochondral element +intersection_of: part_of UBERON:0003635 ! pedal digit 5 +union_of: UBERON:0003863 ! pedal digit 5 phalanx +union_of: UBERON:0010584 ! pedal digit 5 phalanx pre-cartilage condensation +union_of: UBERON:0010684 ! pedal digit 5 phalanx cartilage element relationship: part_of UBERON:0003635 ! pedal digit 5 relationship: part_of UBERON:5103635 ! pedal digit 5 digitopodial skeleton @@ -298350,6 +415602,11 @@ synonym: "pedal digit metatarsal element" EXACT [https://github.com/obophenotype synonym: "pedal digit metatarsal skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: part_of UBERON:0000983 ! metatarsus region +union_of: UBERON:0010545 ! metatarsus skeleton +union_of: UBERON:0010687 ! pedal digit metatarsal pre-cartilage condensation +union_of: UBERON:0010697 ! pedal digit metatarsal cartilage element relationship: part_of UBERON:0000983 ! metatarsus region relationship: part_of UBERON:0012152 ! skeleton of pedal digitopodium @@ -298362,6 +415619,11 @@ synonym: "pedal digit 1 metatarsal element" EXACT [https://github.com/obophenoty synonym: "pedal digit 1 metatarsal skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit I metatarsal endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: part_of UBERON:5103631 ! pedal digit 1 digitopodial skeleton +union_of: UBERON:0003650 ! metatarsal bone of digit 1 +union_of: UBERON:0010547 ! pedal digit 1 metatarsal pre-cartilage condensation +union_of: UBERON:0010557 ! pedal digit 1 metatarsal cartilage element relationship: part_of UBERON:5103631 ! pedal digit 1 digitopodial skeleton [Term] @@ -298406,6 +415668,11 @@ synonym: "pedal digit 5 metatarsal element" EXACT [https://github.com/obophenoty synonym: "pedal digit 5 metatarsal skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "pedal digit V metatarsal endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: UBERON:0015036 ! pedal digit metatarsal endochondral element +intersection_of: part_of UBERON:5103635 ! pedal digit 5 digitopodial skeleton +union_of: UBERON:0003654 ! metatarsal bone of digit 5 +union_of: UBERON:0010551 ! pedal digit 5 metatarsal pre-cartilage condensation +union_of: UBERON:0010561 ! pedal digit 5 metatarsal cartilage element relationship: part_of UBERON:5103635 ! pedal digit 5 digitopodial skeleton [Term] @@ -298417,6 +415684,11 @@ synonym: "manual digit metacarpus element" EXACT [https://github.com/obophenotyp synonym: "manual digit metacarpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: part_of UBERON:0004453 ! metacarpus region +union_of: UBERON:0010544 ! metacarpus skeleton +union_of: UBERON:0010698 ! manual digit metacarpus pre-cartilage condensation +union_of: UBERON:0010699 ! manual digit metacarpus cartilage element relationship: part_of UBERON:0004453 ! metacarpus region relationship: part_of UBERON:0012151 ! skeleton of manual digitopodium @@ -298429,6 +415701,11 @@ synonym: "manual digit 1 metacarpus element" EXACT [https://github.com/obophenot synonym: "manual digit 1 metacarpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit I metacarpus endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: part_of UBERON:5101463 ! manual digit 1 digitopodial skeleton +union_of: UBERON:0003645 ! metacarpal bone of digit 1 +union_of: UBERON:0010565 ! manual digit 1 metacarpus pre-cartilage condensation +union_of: UBERON:0010570 ! manual digit 1 metacarpus cartilage element relationship: part_of UBERON:5101463 ! manual digit 1 digitopodial skeleton [Term] @@ -298473,6 +415750,11 @@ synonym: "manual digit 5 metacarpus element" EXACT [https://github.com/obophenot synonym: "manual digit 5 metacarpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "manual digit V metacarpus endochondral element" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: UBERON:0015042 ! manual digit metacarpus endochondral element +intersection_of: part_of UBERON:5103625 ! manual digit 5 digitopodial skeleton +union_of: UBERON:0003649 ! metacarpal bone of digit 5 +union_of: UBERON:0010569 ! manual digit 5 metacarpus pre-cartilage condensation +union_of: UBERON:0010574 ! manual digit 5 metacarpus cartilage element relationship: part_of UBERON:5103625 ! manual digit 5 digitopodial skeleton [Term] @@ -298496,6 +415778,11 @@ synonym: "carpus element" EXACT [https://github.com/obophenotype/uberon/wiki/Mod synonym: "carpus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: part_of UBERON:0004452 ! carpal region +union_of: UBERON:0001435 ! carpal bone +union_of: UBERON:0006213 ! carpus cartilage element +union_of: UBERON:0006214 ! carpus pre-cartilage condensation relationship: part_of UBERON:0009880 ! carpal skeleton [Term] @@ -298507,6 +415794,11 @@ synonym: "tarsus element" EXACT [https://github.com/obophenotype/uberon/wiki/Mod synonym: "tarsus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: part_of UBERON:0004454 ! tarsal region +union_of: UBERON:0001447 ! tarsal bone +union_of: UBERON:0010540 ! tarsus pre-cartilage condensation +union_of: UBERON:0010541 ! tarsus cartilage element relationship: part_of UBERON:0009879 ! tarsal skeleton [Term] @@ -298530,6 +415822,9 @@ def: "A femur bone or its cartilage or pre-cartilage precursor." [https://github synonym: "femur element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "femur skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015022 ! hindlimb endochondral element +union_of: UBERON:0000981 ! femur +union_of: UBERON:0006234 ! femur pre-cartilage condensation +union_of: UBERON:0010129 ! femur cartilage element relationship: part_of UBERON:0000376 ! hindlimb stylopod [Term] @@ -298540,6 +415835,9 @@ def: "A humerus bone or its cartilage or pre-cartilage precursor." [https://gith synonym: "humerus element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "humerus skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0015021 ! forelimb endochondral element +union_of: UBERON:0000976 ! humerus +union_of: UBERON:0006245 ! humerus cartilage element +union_of: UBERON:0006246 ! humerus pre-cartilage condensation relationship: part_of UBERON:0003822 ! forelimb stylopod [Term] @@ -298552,6 +415850,9 @@ synonym: "iliac skeletal element" BROAD [https://github.com/obophenotype/uberon/ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001273 ! ilium +union_of: UBERON:0006247 ! iliac pre-cartilage condensation +union_of: UBERON:0010714 ! iliac cartilage element relationship: part_of UBERON:0007832 ! pelvic girdle skeleton [Term] @@ -298564,6 +415865,9 @@ synonym: "pubic skeletal element" BROAD [https://github.com/obophenotype/uberon/ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001275 ! pubis +union_of: UBERON:0006285 ! pubic pre-cartilage condensation +union_of: UBERON:0010718 ! pubic cartilage element relationship: part_of UBERON:0007832 ! pelvic girdle skeleton [Term] @@ -298576,6 +415880,9 @@ synonym: "ischial skeletal element" BROAD [https://github.com/obophenotype/ubero is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005179 ! pelvic region element is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001274 ! ischium +union_of: UBERON:0006254 ! ischial cartilage element +union_of: UBERON:0006255 ! ischial pre-cartilage condensation relationship: part_of UBERON:0007832 ! pelvic girdle skeleton [Term] @@ -298586,6 +415893,9 @@ def: "A scapula bone or its cartilage or pre-cartilage precursor." [https://gith synonym: "scapula element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] synonym: "scapula skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0006290 ! scapula cartilage element +union_of: UBERON:0006291 ! scapula pre-cartilage condensation +union_of: UBERON:0006849 ! scapula relationship: part_of UBERON:0007831 ! pectoral girdle skeleton [Term] @@ -298608,6 +415918,9 @@ synonym: "orbitosphenoid element" EXACT [https://github.com/obophenotype/uberon/ synonym: "orbitosphenoid skeletal element" BROAD [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0002478 ! orbitosphenoid +union_of: UBERON:0005687 ! orbitosphenoid cartilage element +union_of: UBERON:0010728 ! sphenoid lesser wing pre-cartilage condensation relationship: part_of UBERON:0002517 ! basicranium relationship: part_of UBERON:0003111 ! sphenoid region @@ -298620,6 +415933,9 @@ synonym: "sphenoid bone skeletal element" BROAD [https://github.com/obophenotype synonym: "sphenoid element" EXACT [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001677 ! sphenoid bone +union_of: UBERON:0009191 ! sphenoid bone pre-cartilage condensation +union_of: UBERON:0009193 ! sphenoid cartilage element relationship: part_of UBERON:0011156 ! facial skeleton [Term] @@ -298644,6 +415960,8 @@ name: autopod endochondral element namespace: uberon def: "An endochondral element that is part of a autopod region." [OBOL:automatic] is_a: UBERON:0015061 ! limb endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: part_of UBERON:0002470 ! autopod region relationship: part_of UBERON:0006717 {source="cjm"} ! autopodial skeleton property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern @@ -298654,6 +415972,8 @@ namespace: uberon def: "An autopod endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0010881 ! limb cartilage element is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0015063 ! autopod endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue property_value: UBPROP:0000006 https://github.com/obophenotype/uberon/wiki/Skeleton-partonomy-Design-Pattern [Term] @@ -298704,6 +416024,8 @@ synonym: "proximal carpal" RELATED SYSTEMATIC [UBERON:cjm] synonym: "proximal carpal element" EXACT [UBERON:cjm] is_a: UBERON:0015049 ! carpus endochondral element is_a: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: part_of UBERON:0002102 ! forelimb [Term] id: UBERON:0015079 @@ -298713,6 +416035,8 @@ def: "A proximal carpal endochondral element that is composed primarily of carti is_a: UBERON:0015078 ! proximal carpal endochondral element is_a: UBERON:0017751 ! proximal mesopodial cartilage element is_a: UBERON:0035128 ! manus cartilage element +intersection_of: UBERON:0015078 ! proximal carpal endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0015080 ! proximal carpal bone pre-cartilage condensation [Term] @@ -298722,6 +416046,8 @@ namespace: uberon def: "A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0010884 ! forelimb bone pre-cartilage condensation is_a: UBERON:0015078 ! proximal carpal endochondral element +intersection_of: UBERON:0015078 ! proximal carpal endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0015081 @@ -298731,6 +416057,8 @@ def: "A proximal mesopodial endochondral element that is part of a hindlimb." [O synonym: "proximal tarsal" RELATED SYSTEMATIC [UBERON:cjm] is_a: UBERON:0015050 ! tarsus endochondral element is_a: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: part_of UBERON:0002103 ! hindlimb [Term] id: UBERON:0015082 @@ -298740,6 +416068,8 @@ def: "A proximal tarsal endochondral element that is composed primarily of carti is_a: UBERON:0015081 ! proximal tarsal endochondral element is_a: UBERON:0017751 ! proximal mesopodial cartilage element is_a: UBERON:0035129 ! pes cartilage element +intersection_of: UBERON:0015081 ! proximal tarsal endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue relationship: develops_from UBERON:0015083 ! proximal tarsal bone pre-cartilage condensation [Term] @@ -298749,6 +416079,8 @@ namespace: uberon def: "A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] is_a: UBERON:0010886 ! hindlimb pre-cartilage condensation is_a: UBERON:0015081 ! proximal tarsal endochondral element +intersection_of: UBERON:0015081 ! proximal tarsal endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0015084 @@ -298880,6 +416212,16 @@ relationship: adjacent_to UBERON:0002425 ! visceral serous pericardium relationship: composed_primarily_of CL:1000309 ! epicardial adipocyte relationship: part_of UBERON:0015128 ! subepicardial layer of epicardium +[Term] +id: UBERON:0015130 +name: connective tissue of prostate gland +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0011822 ! dense irregular connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + [Term] id: UBERON:0015139 name: infundibulum of gallbladder @@ -298893,6 +416235,17 @@ is_a: UBERON:0000064 ! organ part is_a: UBERON:0004119 ! endoderm-derived structure relationship: part_of UBERON:0002110 {source="FMA"} ! gall bladder +[Term] +id: UBERON:0015142 +name: falciform fat +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003427 ! abdominal fat pad +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0015143 ! mesenteric fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001247 ! falciform ligament +relationship: part_of UBERON:0001247 ! falciform ligament + [Term] id: UBERON:0015143 name: mesenteric fat pad @@ -298901,8 +416254,66 @@ def: "Encapsulated adipose tissue associated with the mesentery." [MP:0008903] synonym: "mesenteric fat depot" EXACT [MP:0008903] is_a: UBERON:0003916 ! fat pad is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0002095 ! mesentery relationship: part_of UBERON:0002095 ! mesentery +[Term] +id: UBERON:0015144 +name: autopod hair +is_a: UBERON:0037459 ! hair of limb +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002470 ! autopod region +relationship: part_of UBERON:0002470 ! autopod region + +[Term] +id: UBERON:0015145 +name: pes hair +is_a: UBERON:0015144 ! autopod hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002387 ! pes +relationship: part_of UBERON:0002387 ! pes + +[Term] +id: UBERON:0015146 +name: manus hair +is_a: UBERON:0015144 ! autopod hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002398 ! manus +relationship: part_of UBERON:0002398 ! manus + +[Term] +id: UBERON:0015147 +name: pinna hair +is_a: UBERON:0022279 ! strand of hair on external ear +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0001757 ! pinna +relationship: part_of UBERON:0001757 ! pinna + +[Term] +id: UBERON:0015148 +name: tail hair +is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002415 ! tail +relationship: part_of UBERON:0002415 ! tail + +[Term] +id: UBERON:0015149 +name: ventral hair +is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0013235 ! ventrum +relationship: part_of UBERON:0013235 ! ventrum + +[Term] +id: UBERON:0015150 +name: dorsal hair +is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0001137 ! dorsum +relationship: part_of UBERON:0001137 ! dorsum + [Term] id: UBERON:0015152 name: gland of ocular region @@ -298940,6 +416351,17 @@ synonym: "lateral orbital gland" EXACT [] is_a: UBERON:0015152 ! gland of ocular region property_value: IAO:0000232 "The class name or definition should not be taken to mean strictly in the lateral ocular region. We place the extraocular lacrimal glands, even though they are as the name suggests outside the ocular region. The class exists as the division between lateral vs medial (Harderian, nictitans) glands is standard, e.g. http://www.ncbi.nlm.nih.gov/pubmed/7559104" xsd:string +[Term] +id: UBERON:0015155 +name: conjunctival space +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001811 ! conjunctiva +relationship: luminal_space_of UBERON:0001811 ! conjunctiva +relationship: part_of UBERON:0005908 ! conjunctival sac + [Term] id: UBERON:0015156 name: terminal branch of ophthalmic artery @@ -298973,6 +416395,7 @@ id: UBERON:0015171 name: uterine spiral artery namespace: uberon def: "A corkscrew-like artery in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)." [J:100668, J:117841, MGI:anna, MP:0012726] +subset: human_reference_atlas subset: pheno_slim synonym: "endometrial spiral arteriole" EXACT [] synonym: "endometrial spiral artery" EXACT [BTO:0003371] @@ -298987,6 +416410,7 @@ xref: UMLS:C1519470 xref: Wikipedia:Spiral_artery is_a: UBERON:0001637 {source="BTO"} ! artery is_a: UBERON:0015172 ! endometrial blood vessel +property_value: RO:0002175 NCBITaxon:9606 property_value: UBPROP:0000001 "In women, rats and mice, the endometrial vessels are coiled and known as spiral arteries[PMID:16413937]." xsd:string {source="PMID:16413937"} [Term] @@ -298994,11 +416418,15 @@ id: UBERON:0015172 name: endometrial blood vessel namespace: uberon def: "A blood vessel that is part of a endometrium." [OBOL:automatic] +subset: human_reference_atlas synonym: "blood vessel of endometrium" EXACT [] xref: SCTID:254200009 is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0015178 @@ -299053,6 +416481,16 @@ is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0018664 ! neck of bone element relationship: part_of UBERON:0002395 ! talus +[Term] +id: UBERON:0015181 +name: neck of tooth +is_a: UBERON:0001560 ! neck of organ +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0001091 ! calcareous tooth +relationship: part_of UBERON:0001091 ! calcareous tooth + [Term] id: UBERON:0015212 name: lateral structure @@ -299067,6 +416505,20 @@ relationship: in_lateral_side_of UBERON:0000465 ! material anatomical entity relationship: only_in_taxon NCBITaxon:33213 ! Bilateria property_value: IAO:0000232 "This class is primarily to implement taxon constraints. It may be removed in the future." xsd:string +[Term] +id: UBERON:0015214 +name: arcuate ligament +namespace: uberon +def: "A ligament that is part of a diaphragm." [OBOL:automatic] +xref: EMAPA:19236 +xref: FMA:58280 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000211 ! ligament +is_a: UBERON:0005181 ! thoracic segment organ +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0001103 ! diaphragm +relationship: part_of UBERON:0001103 ! diaphragm + [Term] id: UBERON:0015228 name: circulatory organ @@ -299124,6 +416576,8 @@ subset: pheno_slim xref: EMAPA:32615 xref: MA:0003011 is_a: UBERON:0015790 ! autopod skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002544 ! digit relationship: part_of UBERON:0002544 ! digit [Term] @@ -299134,6 +416588,32 @@ xref: EMAPA:37680 {source="MA:th"} xref: MA:0003043 is_a: UBERON:0001821 {source="MA"} ! sebaceous gland +[Term] +id: UBERON:0015280 +name: pancreas left lobe +namespace: uberon +def: "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." [OBOL:automatic] +xref: EMAPA:37711 {source="MA:th"} +xref: MA:0000722 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: in_left_side_of UBERON:0000017 ! exocrine pancreas +relationship: in_left_side_of UBERON:0000017 ! exocrine pancreas + +[Term] +id: UBERON:0015281 +name: pancreas right lobe +namespace: uberon +def: "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." [OBOL:automatic] +xref: EMAPA:37712 {source="MA:th"} +xref: MA:0000723 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: in_right_side_of UBERON:0000017 ! exocrine pancreas +relationship: in_right_side_of UBERON:0000017 ! exocrine pancreas + [Term] id: UBERON:0015329 name: respiratory system basement membrane @@ -299182,8 +416662,128 @@ is_a: UBERON:0003978 ! valve is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003978 ! valve intersection_of: part_of UBERON:0000056 ! ureter +relationship: capable_of GO:0035809 ! regulation of urine volume relationship: part_of UBERON:0000056 ! ureter +[Term] +id: UBERON:0015453 +name: subcutaneous lymph node +is_a: UBERON:0000029 ! lymph node +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0002072 ! hypodermis +relationship: part_of UBERON:0002072 ! hypodermis + +[Term] +id: UBERON:0015454 +name: pancreatic fat pad +is_a: UBERON:0003586 ! trunk connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas + +[Term] +id: UBERON:0015458 +name: mediastinal fat pad +is_a: UBERON:0003593 ! thoracic cavity connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: located_in UBERON:0003728 ! mediastinum +relationship: located_in UBERON:0003728 ! mediastinum + +[Term] +id: UBERON:0015474 +name: axilla skin +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0009472 ! axilla +relationship: part_of UBERON:0009472 ! axilla + +[Term] +id: UBERON:0015476 +name: nose skin +is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0007827 ! external nose +relationship: part_of UBERON:0007827 ! external nose + +[Term] +id: UBERON:0015477 +name: axillary fat pad +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0009472 ! axilla +relationship: part_of UBERON:0009472 ! axilla + +[Term] +id: UBERON:0015479 +name: scrotum skin +is_a: UBERON:0000014 ! zone of skin +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001300 ! scrotum +relationship: part_of UBERON:0001300 ! scrotum + +[Term] +id: UBERON:0015480 +name: proper hepatic artery +namespace: uberon +def: "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." [Wikipedia:Hepatic_artery_proper] +subset: human_reference_atlas +synonym: "hepatic artery proper" EXACT [FMA:14772] +synonym: "proper hepatic" RELATED [Wikipedia:Hepatic_artery_proper] +xref: EMAPA:37217 {source="MA:th"} +xref: FMA:14772 +xref: MA:0003095 +xref: SCTID:244262006 +xref: Wikipedia:Hepatic_artery_proper +is_a: UBERON:0001193 {source="MA"} ! hepatic artery +is_a: UBERON:0004573 ! systemic artery +relationship: branching_part_of UBERON:0005436 {source="FMA"} ! common hepatic artery +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0015481 +name: left hepatic artery +namespace: uberon +def: "A hepatic artery that is part of a left lobe of liver." [OBOL:automatic] +subset: human_reference_atlas +synonym: "left branch of hepatic artery" EXACT [FMA:14779] +synonym: "left part of hepatic artery proper" EXACT [FMA:14779] +synonym: "ramus sinister (arteria hepatica propria)" EXACT LATIN [FMA:14779, FMA:TA] +xref: EMAPA:37096 {source="MA:th"} +xref: FMA:14779 +xref: MA:0003096 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: part_of UBERON:0001115 ! left lobe of liver +relationship: connected_to UBERON:0015480 ! proper hepatic artery +relationship: part_of UBERON:0001115 {source="FMA"} ! left lobe of liver +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0015482 +name: right hepatic artery +namespace: uberon +def: "A hepatic artery that is part of a right lobe of liver." [OBOL:automatic] +subset: human_reference_atlas +synonym: "ramus dexter (arteria hepatica propria)" EXACT LATIN [FMA:14778, FMA:TA] +synonym: "right branch of hepatic artery proper" EXACT [FMA:14778] +synonym: "right part of hepatic artery proper" EXACT [FMA:14778] +xref: EMAPA:37376 {source="MA:th"} +xref: FMA:14778 +xref: MA:0003097 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: part_of UBERON:0001114 ! right lobe of liver +relationship: connected_to UBERON:0015480 ! proper hepatic artery +relationship: part_of UBERON:0001114 {source="FMA"} ! right lobe of liver +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0015484 name: epidermis of metapodial pad @@ -299198,6 +416798,21 @@ is_a: UBERON:0019204 ! skin epithelium relationship: part_of UBERON:0008838 ! metapodial pad property_value: UBPROP:0000012 "MA distinguishes between foot pad and foot pad skin, but its not clear how these differ if foot pads are skin. See https://github.com/obophenotype/uberon/issues/1305" xsd:string {external_ontology="MA"} +[Term] +id: UBERON:0015485 +name: choledocho-duodenal junction +namespace: uberon +def: "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." [http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction] +synonym: "choledochoduodenal junction" EXACT [MA:0003108] +xref: EMAPA:37478 {source="MA:th"} +xref: MA:0003108 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0002114 ! duodenum +intersection_of: connects UBERON:0002394 ! bile duct +relationship: connects UBERON:0002114 ! duodenum +relationship: connects UBERON:0002394 ! bile duct + [Term] id: UBERON:0015593 name: frontal gyrus @@ -299213,6 +416828,8 @@ id: UBERON:0015716 name: anal canal epithelium namespace: uberon def: "A epithelium that is part of a anal canal." [OBOL:automatic] +def: "An epithelium that is part of a anal canal." [OBOL:automatic] +subset: human_reference_atlas synonym: "anal canal epithelium" EXACT [FMA:17511] synonym: "epithelium of anal canal" EXACT [FMA:17511] xref: EMAPA:18835 @@ -299222,6 +416839,25 @@ is_a: UBERON:0014703 ! anal membrane ectodermal component intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000159 ! anal canal relationship: part_of UBERON:0000159 ! anal canal +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0015717 +name: smooth muscle tissue layer of ejaculatory duct +is_a: UBERON:0001135 ! smooth muscle tissue +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0000999 ! ejaculatory duct +relationship: part_of UBERON:0000999 ! ejaculatory duct + +[Term] +id: UBERON:0015751 +name: inferior tarsal muscle +is_a: UBERON:0003386 ! smooth muscle of eye +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0004774 ! inferior eyelid tarsus +relationship: part_of UBERON:0004774 ! inferior eyelid tarsus [Term] id: UBERON:0015757 @@ -299231,6 +416867,23 @@ synonym: "portion of heterogeneous tissue" EXACT [FMA:62798] xref: FMA:62798 is_a: UBERON:0000479 {source="FMA"} ! tissue +[Term] +id: UBERON:0015766 +name: epithelium of duct of salivary gland +is_a: UBERON:0004809 ! salivary gland epithelium +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001837 ! duct of salivary gland +relationship: part_of UBERON:0001837 ! duct of salivary gland + +[Term] +id: UBERON:0015777 +name: transitional epithelium of prostatic urethra +is_a: UBERON:0004787 ! urethra urothelium +is_a: UBERON:0016510 ! epithelium of male urethra +relationship: part_of UBERON:0001335 ! prostatic urethra + [Term] id: UBERON:0015783 name: smooth muscle layer in fatty layer of subcutaneous tissue @@ -299253,6 +416906,8 @@ synonym: "respiratory conduit" RELATED [FMA:265132] xref: FMA:265132 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: part_of UBERON:0001557 ! upper respiratory tract relationship: part_of UBERON:0001557 ! upper respiratory tract property_value: UBPROP:0000001 "Anatomical cluster which consists a segment of the upper respiratory tract[FMA:265132]." xsd:string {source="FMA:265132"} @@ -299290,8 +416945,37 @@ synonym: "paw skin" RELATED [MA:0003120] xref: EMAPA:32723 xref: MA:0003120 is_a: UBERON:0001419 ! skin of limb +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0002470 ! autopod region relationship: part_of UBERON:0002470 ! autopod region +[Term] +id: UBERON:0015791 +name: digit connective tissue +is_a: UBERON:0003587 ! limb connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: part_of UBERON:0002544 ! digit +relationship: part_of UBERON:0002544 ! digit +relationship: transformation_of UBERON:0010702 ! digit mesenchyme + +[Term] +id: UBERON:0015794 +name: left lung lobar bronchus epithelium +is_a: UBERON:0002339 ! epithelium of lobar bronchus +is_a: UBERON:0003365 ! epithelium of left lung +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003405 ! lobar bronchus of left lung +relationship: part_of UBERON:0003405 ! lobar bronchus of left lung + +[Term] +id: UBERON:0015795 +name: right lung lobar bronchus epitheium +is_a: UBERON:0002339 ! epithelium of lobar bronchus +is_a: UBERON:0003364 ! epithelium of right lung +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0003404 ! lobar bronchus of right lung +relationship: part_of UBERON:0003404 ! lobar bronchus of right lung + [Term] id: UBERON:0015796 name: liver blood vessel @@ -299302,6 +416986,8 @@ xref: EMAPA:35498 xref: MA:0003137 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver [Term] @@ -299312,6 +416998,8 @@ def: "An epithelium that is part of a ear." [OBOL:automatic] xref: EMAPA:32800 xref: MA:0003161 is_a: UBERON:0019304 ! sensory organ epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001690 ! ear relationship: part_of UBERON:0001690 ! ear [Term] @@ -299328,6 +417016,22 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000019 ! camera-type eye relationship: part_of UBERON:0000019 ! camera-type eye +[Term] +id: UBERON:0015813 +name: middle ear epithelium +is_a: UBERON:0015807 ! ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001756 ! middle ear +relationship: part_of UBERON:0001756 ! middle ear + +[Term] +id: UBERON:0015814 +name: outer ear epithelium +is_a: UBERON:0015807 ! ear epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001691 ! external ear +relationship: part_of UBERON:0001691 ! external ear + [Term] id: UBERON:0015833 name: foregut epithelium @@ -299341,6 +417045,24 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0001041 ! foregut relationship: part_of UBERON:0001041 ! foregut +[Term] +id: UBERON:0015834 +name: duodenum lamina propria +namespace: uberon +def: "A lamina propria that is part of a duodenum." [OBOL:automatic] +subset: human_reference_atlas +synonym: "duodenal lamina propria" EXACT [FMA:15972] +synonym: "lamina propria mucosae of duodenum" EXACT [FMA:15972] +synonym: "lamina propria of duodenum" EXACT [FMA:15972] +xref: EMAPA:27255 +xref: FMA:15972 +xref: MA:0003209 +is_a: UBERON:0001238 ! lamina propria of small intestine +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0008342 {source="FMA"} ! intestinal villus of duodenum +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0015860 name: visceral abdominal lymph node @@ -299348,6 +417070,30 @@ namespace: uberon xref: FMA:66178 is_a: UBERON:0002507 {source="FMA"} ! abdominal lymph node +[Term] +id: UBERON:0015870 +name: lymph node of head +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0000033 ! head +relationship: part_of UBERON:0000033 ! head + +[Term] +id: UBERON:0015871 +name: facial lymph node +is_a: UBERON:0015870 ! lymph node of head +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0001456 ! face +relationship: part_of UBERON:0001456 ! face + +[Term] +id: UBERON:0015873 +name: heel skin +is_a: UBERON:0001512 ! skin of ankle +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0015875 ! heel +relationship: part_of UBERON:0015875 ! heel + [Term] id: UBERON:0015875 name: heel @@ -299360,9 +417106,29 @@ xref: FMA:24994 xref: MESH:D006365 xref: SCTID:362804005 xref: Wikipedia:Heel +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0005445 ! segment of pes +intersection_of: UBERON:0005445 ! segment of pes +intersection_of: has_skeleton UBERON:0001450 ! calcaneus +relationship: has_skeleton UBERON:0001450 ! calcaneus relationship: part_of UBERON:0004454 ! tarsal region +[Term] +id: UBERON:0015917 +name: superficial lymph node +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0035549 ! vasculature of integument +relationship: part_of UBERON:0035549 ! vasculature of integument + +[Term] +id: UBERON:0015918 +name: deep lymph node +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0035551 ! deep vasculature +relationship: part_of UBERON:0035551 ! deep vasculature + [Term] id: UBERON:0016398 name: lymph node of lower limb @@ -299371,8 +417137,27 @@ def: "A lymph node that is part of a hindlimb." [OBOL:automatic] xref: FMA:44310 xref: SCTID:361109000 is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0002103 ! hindlimb relationship: part_of UBERON:0002103 ! hindlimb +[Term] +id: UBERON:0016399 +name: lymph node of upper limb +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0002102 ! forelimb +relationship: part_of UBERON:0002102 ! forelimb + +[Term] +id: UBERON:0016400 +name: infrapatellar fat pad +is_a: UBERON:0003577 ! knee connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0001465 ! knee +relationship: located_in UBERON:0013069 ! popliteal area + [Term] id: UBERON:0016404 name: cervical vertebral arch joint @@ -299401,6 +417186,14 @@ is_a: UBERON:0003526 ! respiratory system capillary intersection_of: UBERON:0001982 ! capillary intersection_of: part_of UBERON:0002048 ! lung +[Term] +id: UBERON:0016410 +name: male breast +is_a: UBERON:0000310 ! breast +intersection_of: UBERON:0000310 ! breast +intersection_of: part_of UBERON:0003101 ! male organism +relationship: part_of UBERON:0003101 ! male organism + [Term] id: UBERON:0016412 name: central part of body of bony vertebral centrum @@ -299474,6 +417267,16 @@ subset: pheno_slim xref: FMA:35324 is_a: UBERON:0007732 ! interphalangeal joint of manual digit 5 is_a: UBERON:0009767 ! proximal interphalangeal joint +intersection_of: UBERON:0009767 ! proximal interphalangeal joint +intersection_of: part_of UBERON:0003625 ! manual digit 5 + +[Term] +id: UBERON:0016435 +name: chest wall +is_a: UBERON:0000060 ! anatomical wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001443 ! chest +relationship: part_of UBERON:0001443 ! chest [Term] id: UBERON:0016440 @@ -299514,6 +417317,8 @@ synonym: "hair of scalp" NARROW [FMA:54241] synonym: "head hair" EXACT [FMA:54241] xref: FMA:54241 is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head [Term] @@ -299525,6 +417330,8 @@ subset: pheno_slim synonym: "trunk hair" EXACT [FMA:54250] xref: FMA:54250 is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk [Term] @@ -299702,6 +417509,41 @@ xref: SCTID:272684007 xref: Wikipedia:Zygomatic_process_of_maxilla is_a: UBERON:0004529 {source="FMA"} ! anatomical projection +[Term] +id: UBERON:0016478 +name: liver stroma +namespace: uberon +def: "A stroma that is part of a liver." [OBOL:automatic] +subset: human_reference_atlas +synonym: "hepatic stroma" EXACT [FMA:17553] +synonym: "stroma of liver" EXACT [FMA:17553] +xref: FMA:17553 +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0002107 ! liver +relationship: part_of UBERON:0002107 ! liver +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0016479 +name: capsule of liver +is_a: UBERON:0003893 ! capsule +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: bounding_layer_of UBERON:0002107 ! liver +relationship: bounding_layer_of UBERON:0002107 ! liver +relationship: composed_primarily_of UBERON:0018135 ! fibrocollagenous connective tissue + +[Term] +id: UBERON:0016481 +name: bronchial lymph node +is_a: UBERON:0000029 ! lymph node +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: part_of UBERON:0002185 ! bronchus + [Term] id: UBERON:0016490 name: auditory system @@ -299709,9 +417551,9 @@ namespace: uberon def: "Is the sensory system for the sense of hearing." [NLXANAT:090817] xref: EMAPA:36002 xref: FMA:7192 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2888 xref: MA:0002443 xref: NCIT:C12889 +xref: neuronames:2888 xref: NLXANAT:090817 xref: OpenCyc:Mx4rvViwtJwpEbGdrcN5Y29ycA xref: UMLS:C0587901 {source="ncithesaurus:Auditory_System"} @@ -299738,6 +417580,16 @@ property_value: UBPROP:0000001 "Skeletal element that surrounds the notochord.[V property_value: UBPROP:0000001 "the main cylindrical portion of the vertebra ventral to the vertebral canal" xsd:string {source="MP:0000141,ISBN:0-683-40008-8,PMID:10572046"} property_value: UBPROP:0000008 "The vertebral centrum may be cartilaginous, develop as cartilage but be replaced by bone or mineralized, or form directly through intramembranous ossification." xsd:string +[Term] +id: UBERON:0016502 +name: stomach fundus lumen +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001160 ! fundus of stomach +relationship: luminal_space_of UBERON:0001160 ! fundus of stomach + [Term] id: UBERON:0016509 name: cavity of right ventricle @@ -299752,6 +417604,37 @@ intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: luminal_space_of UBERON:0002080 ! heart right ventricle relationship: luminal_space_of UBERON:0002080 ! heart right ventricle +[Term] +id: UBERON:0016510 +name: epithelium of male urethra +is_a: UBERON:0002325 ! epithelium of urethra +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001333 ! male urethra +relationship: part_of UBERON:0001333 ! male urethra + +[Term] +id: UBERON:0016511 +name: lamina propria of fundus of stomach +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0004994 ! mucosa of fundus of stomach +relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach + +[Term] +id: UBERON:0016512 +name: lumen of duodenum +namespace: uberon +def: "An anatomical space that is part of a duodenum." [OBOL:automatic] +synonym: "doudenal lumen" EXACT [FMA:FMA] +synonym: "duodenal lumen" EXACT [FMA:FMA] +xref: EMAPA:19080 +xref: FMA:14589 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0002114 ! duodenum +relationship: part_of UBERON:0002114 ! duodenum + [Term] id: UBERON:0016513 name: cavity of left atrium @@ -299779,6 +417662,40 @@ intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: luminal_space_of UBERON:0002084 ! heart left ventricle relationship: luminal_space_of UBERON:0002084 ! heart left ventricle +[Term] +id: UBERON:0016515 +name: muscular layer of prostatic urethra +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: part_of UBERON:0001335 ! prostatic urethra +relationship: part_of UBERON:0001335 ! prostatic urethra + +[Term] +id: UBERON:0016516 +name: lamina propria of prostatic urethra +is_a: UBERON:0002326 ! lamina propria of urethra +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: part_of UBERON:0001335 ! prostatic urethra +relationship: part_of UBERON:0001335 ! prostatic urethra + +[Term] +id: UBERON:0016517 +name: lumen of jejunum +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: part_of UBERON:0002115 ! jejunum +relationship: part_of UBERON:0002115 ! jejunum + +[Term] +id: UBERON:0016520 +name: epithelium of female urethra +is_a: UBERON:0002325 ! epithelium of urethra +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001334 ! female urethra +relationship: part_of UBERON:0001334 ! female urethra + [Term] id: UBERON:0016522 name: cavity of right atrium @@ -299798,6 +417715,7 @@ name: frontal lobe namespace: uberon def: "Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border." [FMA:61824] subset: efo_slim +subset: human_reference_atlas synonym: "frontal cortex" NARROW [FMA:61824] synonym: "frontal region" BROAD [FMA:61824] synonym: "lobi frontales" EXACT LATIN [NeuroNames:56] @@ -299813,17 +417731,21 @@ xref: EFO:0000913 xref: EV:0100167 xref: FMA:61824 xref: HBA:4009 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=56 {source="BIRNLEX:928"} xref: MAT:0000505 -xref: MESH:A08.186.211.730.885.213.270 +xref: MESH:D005625 xref: NCIT:C12352 +xref: neuronames:56 {source="BIRNLEX:928"} xref: OpenCyc:Mx4rv3OJ8JwpEbGdrcN5Y29ycA xref: SCTID:180920004 xref: UMLS:C0016733 {source="BIRNLEX:928"} xref: UMLS:C0016733 {source="ncithesaurus:Frontal_Lobe"} xref: UMLS:C1268977 {source="BIRNLEX:928"} is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere +relationship: adjacent_to UBERON:0001871 ! temporal lobe +relationship: adjacent_to UBERON:0001872 ! parietal lobe +relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon property_value: editor_note "Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though" xsd:string {source="MM"} +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016526 @@ -299844,7 +417766,7 @@ synonym: "segment of cerebral cortex" RELATED [BIRNLEX:922] xref: BIRNLEX:922 xref: BTO:0000445 xref: FMA:61823 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1210 +xref: neuronames:1210 xref: SCTID:272632001 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure @@ -299852,6 +417774,23 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre relationship: part_of UBERON:0001869 ! cerebral hemisphere property_value: UBPROP:0000202 FMA:77800 +[Term] +id: UBERON:0016527 +name: white matter of cerebral lobe +is_a: UBERON:0002437 ! cerebral hemisphere white matter +intersection_of: UBERON:0002437 ! cerebral hemisphere white matter +intersection_of: part_of UBERON:0016526 ! lobe of cerebral hemisphere +relationship: deep_to UBERON:0016529 ! cortex of cerebral lobe +relationship: part_of UBERON:0016526 ! lobe of cerebral hemisphere + +[Term] +id: UBERON:0016528 +name: white matter of frontal lobe +is_a: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: part_of UBERON:0016525 ! frontal lobe +relationship: part_of UBERON:0016525 ! frontal lobe + [Term] id: UBERON:0016529 name: cortex of cerebral lobe @@ -299863,6 +417802,9 @@ synonym: "gray matter of lobe of cerebral hemisphere" RELATED [FMA:242197] synonym: "neocortical part of cerebral hemisphere" RELATED [] xref: FMA:242197 is_a: UBERON:0005401 ! cerebral hemisphere gray matter +intersection_of: UBERON:0005401 ! cerebral hemisphere gray matter +intersection_of: part_of UBERON:0001950 ! neocortex +intersection_of: part_of UBERON:0016526 ! lobe of cerebral hemisphere relationship: part_of UBERON:0001950 ! neocortex relationship: part_of UBERON:0016526 ! lobe of cerebral hemisphere @@ -299880,28 +417822,61 @@ xref: DHBA:10208 xref: DMBA:16016 xref: EMAPA:35667 xref: FMA:242203 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2473 xref: MA:0000916 +xref: neuronames:2473 xref: NLX:79282 xref: SCTID:369217001 is_a: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: part_of UBERON:0001872 ! parietal lobe relationship: part_of UBERON:0001872 ! parietal lobe +[Term] +id: UBERON:0016531 +name: white matter of parietal lobe +is_a: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: part_of UBERON:0001872 ! parietal lobe +relationship: part_of UBERON:0001872 ! parietal lobe + +[Term] +id: UBERON:0016534 +name: white matter of temporal lobe +is_a: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: part_of UBERON:0001871 ! temporal lobe +relationship: part_of UBERON:0001871 ! temporal lobe + +[Term] +id: UBERON:0016535 +name: white matter of occipital lobe +is_a: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: part_of UBERON:0002021 ! occipital lobe +relationship: part_of UBERON:0002021 ! occipital lobe + +[Term] +id: UBERON:0016536 +name: white matter of limbic lobe +is_a: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: UBERON:0016527 ! white matter of cerebral lobe +intersection_of: part_of UBERON:0002600 ! limbic lobe +relationship: part_of UBERON:0002600 ! limbic lobe + +[Term] +id: UBERON:0016538 +name: temporal cortex +is_a: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: part_of UBERON:0001871 ! temporal lobe +relationship: part_of UBERON:0001871 ! temporal lobe + [Term] id: UBERON:0016540 name: occipital cortex -namespace: uberon -synonym: "cortex of occipital lobe" EXACT [FMA:242205] -synonym: "gray matter of occipital lobe" RELATED [FMA:242205] -synonym: "occipital lobe cortex" EXACT [FMA:242205] -synonym: "occipital neocortex" EXACT [DHBA:10268] -xref: DHBA:10268 -xref: DMBA:16030 -xref: EMAPA:35604 -xref: FMA:242205 -xref: MA:0000913 -xref: PBA:4004 is_a: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: part_of UBERON:0002021 ! occipital lobe relationship: part_of UBERON:0002021 ! occipital lobe [Term] @@ -299913,6 +417888,8 @@ synonym: "gray matter of limbic lobe" RELATED [FMA:242234] synonym: "limbic lobe cortex" EXACT [FMA:242234] xref: FMA:242234 is_a: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: UBERON:0016529 ! cortex of cerebral lobe +intersection_of: part_of UBERON:0002600 ! limbic lobe relationship: part_of UBERON:0002600 ! limbic lobe [Term] @@ -299969,11 +417946,24 @@ namespace: uberon is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: part_of UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0016552 +name: phlegm +namespace: uberon +def: "Mucus produced in the respiratory tract." [http://orcid.org/0000-0002-6601-2165] +xref: NCIT:C93171 +xref: UMLS:C0225378 +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: produced_by UBERON:0000065 ! respiratory tract +relationship: produced_by UBERON:0000065 ! respiratory tract + [Term] id: UBERON:0016553 name: respiratory system mucus namespace: uberon def: "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." [http://en.wikipedia.org/wiki/Nasal_mucus#Respiratory_system, http://orcid.org/0000-0002-6601-2165] +def: "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Nasal_mucus#Respiratory_system] is_a: UBERON:0000912 ! mucus intersection_of: UBERON:0000912 ! mucus intersection_of: produced_by UBERON:0004785 ! respiratory system mucosa @@ -299984,6 +417974,7 @@ id: UBERON:0016554 name: white matter of midbrain namespace: uberon def: "A white matter that is part of the midbrain." [OBOL:automatic] +subset: human_reference_atlas synonym: "mesencephalic white matter" EXACT [HBA:MESWM] xref: DHBA:10650 xref: FMA:83936 @@ -299992,6 +417983,16 @@ is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0016565 +name: cerebral blood vessel +is_a: UBERON:0003499 ! brain blood vessel +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum [Term] id: UBERON:0016566 @@ -300038,6 +418039,9 @@ namespace: uberon def: "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000477 ! anatomical cluster +intersection_of: UBERON:0000477 ! anatomical cluster +intersection_of: develops_from UBERON:0004362 ! pharyngeal arch 1 +intersection_of: part_of UBERON:0006208 ! auditory hillocks relationship: develops_from UBERON:0004362 ! pharyngeal arch 1 relationship: part_of UBERON:0006208 ! auditory hillocks @@ -300048,6 +418052,9 @@ namespace: uberon def: "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle] is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000477 ! anatomical cluster +intersection_of: UBERON:0000477 ! anatomical cluster +intersection_of: develops_from UBERON:0003066 ! pharyngeal arch 2 +intersection_of: part_of UBERON:0006208 ! auditory hillocks relationship: develops_from UBERON:0003066 ! pharyngeal arch 2 relationship: part_of UBERON:0006208 ! auditory hillocks @@ -300065,7 +418072,7 @@ synonym: "supplementary motor area" RELATED [NeuroNames:3176, Wikipedia:Suppleme synonym: "supplementary motor area (M II)" RELATED [NeuroNames:3176] synonym: "supplementary motor cortex" RELATED [NeuroNames:3176] xref: FMA:224858 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3176 +xref: neuronames:3176 xref: Wikipedia:Supplementary_motor_area is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -300081,6 +418088,26 @@ xref: SCTID:67740006 is_a: UBERON:0002419 ! skin gland is_a: UBERON:0011252 ! scent gland is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0011252 ! scent gland +intersection_of: part_of UBERON:0002097 ! skin of body + +[Term] +id: UBERON:0016853 +name: interdigital gland +is_a: UBERON:0016852 ! skin scent gland +intersection_of: UBERON:0016852 ! skin scent gland +intersection_of: part_of UBERON:0012140 ! digitopodium region +relationship: part_of UBERON:0012140 ! digitopodium region + +[Term] +id: UBERON:0016854 +name: dorsal part of optic cup +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000481 ! multi-tissue structure +intersection_of: BSPO:0015101 UBERON:0003072 ! optic cup +relationship: BSPO:0015101 UBERON:0003072 ! optic cup +relationship: part_of UBERON:0003072 ! optic cup [Term] id: UBERON:0016855 @@ -300092,6 +418119,9 @@ synonym: "ventral optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "ventral region of optic cup" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000481 ! multi-tissue structure +intersection_of: BSPO:0015102 UBERON:0003072 ! optic cup +relationship: BSPO:0015102 UBERON:0003072 ! optic cup relationship: part_of UBERON:0003072 ! optic cup [Term] @@ -300146,9 +418176,12 @@ name: shoulder joint namespace: uberon def: "The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints." [http://www.innerbody.com/image/skel17.html] synonym: "joint of shoulder region" EXACT [] +xref: MESH:D012785 xref: SCTID:361835002 is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000982 ! skeletal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: part_of UBERON:0001467 ! shoulder relationship: develops_from UBERON:0006292 {evidence="definitional"} ! shoulder joint primordium relationship: part_of UBERON:0001467 ! shoulder @@ -300201,6 +418234,23 @@ def: "An embryonic anatomical entity that will turn into one or more other anato xref: AEO:0000132 is_a: UBERON:0005423 {source="AEO"} ! developing anatomical structure +[Term] +id: UBERON:0016896 +name: periosteum of long bone +is_a: UBERON:0002515 ! periosteum +intersection_of: UBERON:0002515 ! periosteum +intersection_of: part_of UBERON:0002495 ! long bone +relationship: part_of UBERON:0002495 ! long bone + +[Term] +id: UBERON:0016928 +name: metaphysis of fibula +is_a: UBERON:0001438 ! metaphysis +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001438 ! metaphysis +intersection_of: part_of UBERON:0001446 ! fibula +relationship: part_of UBERON:0001446 ! fibula + [Term] id: UBERON:0016943 name: lower premolar tooth @@ -300223,6 +418273,28 @@ synonym: "upper premolar tooth" EXACT [] is_a: UBERON:0003267 ! tooth of upper jaw is_a: UBERON:0007120 ! premolar tooth +[Term] +id: UBERON:0017163 +name: skin bony tubercle +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0005813 ! tubercle +is_a: UBERON:0013703 ! integumentary projection +intersection_of: UBERON:0005813 ! tubercle +intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue +intersection_of: part_of UBERON:0002199 ! integument +relationship: composed_primarily_of UBERON:0002481 ! bone tissue +relationship: part_of UBERON:0002199 ! integument + +[Term] +id: UBERON:0017261 +name: intertarsal sesamoid +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0011141 ! appendicular ossicle +is_a: UBERON:0013631 ! sesamoid element +intersection_of: UBERON:0013631 ! sesamoid element +intersection_of: part_of UBERON:0009879 ! tarsal skeleton +relationship: part_of UBERON:0009879 ! tarsal skeleton + [Term] id: UBERON:0017270 name: secondary premolar tooth @@ -300234,6 +418306,16 @@ xref: SCTID:422038004 is_a: UBERON:0007120 ! premolar tooth is_a: UBERON:0007775 ! secondary tooth +[Term] +id: UBERON:0017635 +name: paired venous dural sinus +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0005486 ! venous dural sinus +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0005486 ! venous dural sinus +intersection_of: in_lateral_side_of UBERON:0000033 ! head +relationship: in_lateral_side_of UBERON:0000033 ! head + [Term] id: UBERON:0017648 name: ventral body wall @@ -300243,6 +418325,8 @@ synonym: "anterior body wall" RELATED [FMA:86934] xref: EMAPA:37984 {source="MA:th"} xref: FMA:86934 is_a: UBERON:0000309 ! body wall +intersection_of: UBERON:0000309 ! body wall +intersection_of: part_of UBERON:0013235 ! ventrum relationship: part_of UBERON:0013235 ! ventrum [Term] @@ -300273,6 +418357,27 @@ namespace: uberon def: "A primordium that has the potential to develop into a saliva-secreting gland." [OBOL:automatic] is_a: UBERON:0001048 ! primordium is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: has_potential_to_develop_into UBERON:0001044 ! saliva-secreting gland +relationship: has_potential_to_develop_into UBERON:0001044 ! saliva-secreting gland + +[Term] +id: UBERON:0017654 +name: buccal gland +is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: part_of UBERON:0001567 ! cheek +relationship: part_of UBERON:0001567 ! cheek + +[Term] +id: UBERON:0017659 +name: ventral surface of penis +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0036215 ! anatomical surface region +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: BSPO:0015102 UBERON:0000989 ! penis +relationship: BSPO:0015102 UBERON:0000989 ! penis +relationship: part_of UBERON:0000989 ! penis [Term] id: UBERON:0017670 @@ -300400,6 +418505,10 @@ name: proximal mesopodial endochondral element namespace: uberon def: "A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0015063 ! autopod endochondral element +intersection_of: UBERON:0010363 ! endochondral element +intersection_of: connected_to UBERON:0011584 ! zeugopodial skeleton +intersection_of: part_of UBERON:0006716 ! mesopodium region +relationship: connected_to UBERON:0011584 ! zeugopodial skeleton relationship: part_of UBERON:0009878 ! mesopodial skeleton property_value: editor_note "awaiting approval by phenoscape curators" xsd:string @@ -300410,6 +418519,8 @@ namespace: uberon def: "A proximal mesopodial endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] is_a: UBERON:0015064 ! autopod cartilage is_a: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: UBERON:0017750 ! proximal mesopodial endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0018099 @@ -300452,6 +418563,7 @@ id: UBERON:0018111 name: muscle layer of rectum namespace: uberon def: "A muscle layer that is part of the rectum" [http://orcid.org/0000-0002-6601-2165] +def: "A muscle layer that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] synonym: "muscular coat of rectum" EXACT [FMA:15035] synonym: "muscularis externa of rectum" EXACT [FMA:15035] synonym: "rectal muscularis propria" EXACT [FMA:15035] @@ -300468,6 +418580,7 @@ id: UBERON:0018112 name: rectum smooth muscle tissue namespace: uberon def: "Any portion of smooth muscle tissue that is part of the rectum" [http://orcid.org/0000-0002-6601-2165] +def: "Any portion of smooth muscle tissue that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] synonym: "rectal smooth muscle tissue" EXACT [] synonym: "rectum smooth muscle" EXACT [] synonym: "smooth muscle of rectum" EXACT [] @@ -300478,6 +418591,80 @@ intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0001052 ! rectum relationship: part_of UBERON:0001052 ! rectum +[Term] +id: UBERON:0018113 +name: left kidney interstitium +is_a: UBERON:0005215 ! kidney interstitium +intersection_of: UBERON:0005215 ! kidney interstitium +intersection_of: part_of UBERON:0004538 ! left kidney +relationship: part_of UBERON:0004538 ! left kidney + +[Term] +id: UBERON:0018114 +name: right kidney interstitium +is_a: UBERON:0005215 ! kidney interstitium +intersection_of: UBERON:0005215 ! kidney interstitium +intersection_of: part_of UBERON:0004539 ! right kidney +relationship: part_of UBERON:0004539 ! right kidney + +[Term] +id: UBERON:0018115 +name: left renal pelvis +is_a: UBERON:0001224 ! renal pelvis +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001224 ! renal pelvis +intersection_of: part_of UBERON:0001223 ! left ureter +relationship: part_of UBERON:0001223 ! left ureter + +[Term] +id: UBERON:0018116 +name: right renal pelvis +is_a: UBERON:0001224 ! renal pelvis +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0001224 ! renal pelvis +intersection_of: part_of UBERON:0001222 ! right ureter +relationship: part_of UBERON:0001222 ! right ureter + +[Term] +id: UBERON:0018117 +name: left renal cortex interstitium +is_a: UBERON:0005270 ! renal cortex interstitium +is_a: UBERON:0018113 ! left kidney interstitium +intersection_of: UBERON:0005270 ! renal cortex interstitium +intersection_of: part_of UBERON:0004538 ! left kidney + +[Term] +id: UBERON:0018118 +name: right renal cortex interstitium +is_a: UBERON:0005270 ! renal cortex interstitium +is_a: UBERON:0018114 ! right kidney interstitium +intersection_of: UBERON:0005270 ! renal cortex interstitium +intersection_of: part_of UBERON:0004539 ! right kidney + +[Term] +id: UBERON:0018119 +name: left renal medulla interstitium +is_a: UBERON:0005211 ! renal medulla interstitium +is_a: UBERON:0018113 ! left kidney interstitium +intersection_of: UBERON:0005211 ! renal medulla interstitium +intersection_of: part_of UBERON:0004538 ! left kidney + +[Term] +id: UBERON:0018120 +name: right renal medulla interstitium +is_a: UBERON:0005211 ! renal medulla interstitium +is_a: UBERON:0018114 ! right kidney interstitium +intersection_of: UBERON:0005211 ! renal medulla interstitium +intersection_of: part_of UBERON:0004539 ! right kidney + +[Term] +id: UBERON:0018132 +name: tail fat pad +is_a: UBERON:0003599 ! tail connective tissue +is_a: UBERON:0003916 ! fat pad +intersection_of: UBERON:0003916 ! fat pad +intersection_of: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0018135 name: fibrocollagenous connective tissue @@ -300500,8 +418687,47 @@ synonym: "coccyx vertebra element" NARROW [] synonym: "tail vertebra element" EXACT [] is_a: UBERON:0005174 ! dorsal region element is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: part_of UBERON:0006076 ! caudal region of vertebral column +union_of: UBERON:0001095 ! caudal vertebra +union_of: UBERON:0013503 ! caudal vertebra cartilage element +union_of: UBERON:0013504 ! caudal vertebra pre-cartilage condensation relationship: part_of UBERON:0006076 ! caudal region of vertebral column +[Term] +id: UBERON:0018143 +name: transverse process of cervical vertebra +is_a: UBERON:0001077 ! transverse process of vertebra +intersection_of: UBERON:0001077 ! transverse process of vertebra +intersection_of: part_of UBERON:0002413 ! cervical vertebra +relationship: part_of UBERON:0002413 ! cervical vertebra + +[Term] +id: UBERON:0018144 +name: cervical rib +is_a: UBERON:0002228 ! rib +is_a: UBERON:0003458 ! neck bone +intersection_of: UBERON:0002228 ! rib +intersection_of: connected_to UBERON:0002413 ! cervical vertebra +relationship: connected_to UBERON:0002413 ! cervical vertebra +relationship: part_of UBERON:0005434 ! cervical region + +[Term] +id: UBERON:0018145 +name: lumbar rib +is_a: UBERON:0002228 ! rib +intersection_of: UBERON:0002228 ! rib +intersection_of: connected_to UBERON:0002414 ! lumbar vertebra +relationship: connected_to UBERON:0002414 ! lumbar vertebra + +[Term] +id: UBERON:0018146 +name: transverse process of lumbar vertebra +is_a: UBERON:0001077 ! transverse process of vertebra +intersection_of: UBERON:0001077 ! transverse process of vertebra +intersection_of: part_of UBERON:0002414 ! lumbar vertebra +relationship: part_of UBERON:0002414 ! lumbar vertebra + [Term] id: UBERON:0018150 name: skin of lower lip @@ -300517,6 +418743,24 @@ intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0001835 ! lower lip relationship: part_of UBERON:0001835 ! lower lip +[Term] +id: UBERON:0018151 +name: skin of upper lip +is_a: UBERON:0001458 ! skin of lip +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0001834 ! upper lip +relationship: part_of UBERON:0001834 ! upper lip + +[Term] +id: UBERON:0018154 +name: ligament of middle ear +is_a: UBERON:0000211 ! ligament +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0001756 ! middle ear +relationship: part_of UBERON:0001756 ! middle ear + [Term] id: UBERON:0018226 name: pulmonary part of lymphatic system @@ -300528,9 +418772,22 @@ synonym: "pulmonary lymphatic vasculature" RELATED [] xref: FMA:67999 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision +intersection_of: UBERON:0011216 ! organ system subdivision +intersection_of: part_of UBERON:0002048 ! lung +intersection_of: part_of UBERON:0006558 ! lymphatic part of lymphoid system +relationship: has_part UBERON:0018227 ! pulmonary lymphatic vessel relationship: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system +[Term] +id: UBERON:0018227 +name: pulmonary lymphatic vessel +is_a: UBERON:0003456 ! respiratory system lymphatic vessel +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0002048 ! lung +relationship: part_of UBERON:0018226 ! pulmonary part of lymphatic system + [Term] id: UBERON:0018229 name: renin-angiotensin system @@ -300542,11 +418799,19 @@ synonym: "renin angiotensin system" RELATED [MESH:G06.535.805] synonym: "renin-angiotensin system" RELATED [MESH:G06.535.805] synonym: "renin-angiotensin-aldosterone system" RELATED [MESH:G06.535.805] xref: FMA:74787 -xref: MESH:G06.535.805 +xref: MESH:D012084 is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0000949 ! endocrine system property_value: IAO:0000232 "may be replaced by a GO process in future" xsd:string +[Term] +id: UBERON:0018232 +name: axillary sweat gland +is_a: UBERON:0000382 ! apocrine sweat gland +intersection_of: UBERON:0001820 ! sweat gland +intersection_of: part_of UBERON:0009472 ! axilla +relationship: part_of UBERON:0009472 ! axilla + [Term] id: UBERON:0018233 name: gland of Zeis @@ -300562,6 +418827,28 @@ xref: SCTID:281070008 xref: Wikipedia:Gland_of_Zeis is_a: UBERON:0013231 ! sebaceous gland of eyelid +[Term] +id: UBERON:0018234 +name: stroma of pancreas +namespace: uberon +def: "A stroma that is part of a pancreas." [OBOL:automatic] +subset: human_reference_atlas +synonym: "pancreatic stroma" EXACT [FMA:63121] +xref: FMA:63121 +is_a: UBERON:0003891 ! stroma +intersection_of: UBERON:0003891 ! stroma +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0018235 +name: capsule of pancreas +is_a: UBERON:0003893 ! capsule +intersection_of: UBERON:0003893 ! capsule +intersection_of: part_of UBERON:0001264 ! pancreas +relationship: part_of UBERON:0001264 ! pancreas + [Term] id: UBERON:0018239 name: rhombomere boundary @@ -300595,6 +418882,15 @@ is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001682 ! palatine bone +[Term] +id: UBERON:0018243 +name: thymic artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0002370 ! thymus +relationship: branching_part_of UBERON:0002456 ! internal thoracic artery +relationship: supplies UBERON:0002370 ! thymus + [Term] id: UBERON:0018246 name: thyroid vein @@ -300603,6 +418899,17 @@ def: "A vein that drains a thyroid gland." [OBOL:automatic] xref: EMAPA:18648 xref: SCTID:303420005 is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0002046 ! thyroid gland +relationship: drains UBERON:0002046 ! thyroid gland + +[Term] +id: UBERON:0018247 +name: cervical thymic artery +is_a: UBERON:0018243 ! thymic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0009114 ! cervical thymus +relationship: supplies UBERON:0009114 ! cervical thymus [Term] id: UBERON:0018251 @@ -300625,13 +418932,22 @@ subset: grouping_class xref: EHDAA2:0001842 xref: EMAPA:35578 xref: MA:0000165 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0000061 ! anatomical structure relationship: composed_primarily_of UBERON:0014892 ! skeletal muscle organ relationship: part_of UBERON:0000383 {source="MA"} ! musculature of body property_value: editor_note "Added for consistency with MA EMAPA and EHDAA2. See https://github.com/obophenotype/mouse-anatomy-ontology/issues/104" xsd:string +[Term] +id: UBERON:0018255 +name: jejunal artery +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001182 ! superior mesenteric artery +intersection_of: supplies UBERON:0002115 ! jejunum +relationship: branching_part_of UBERON:0001182 ! superior mesenteric artery +relationship: supplies UBERON:0002115 ! jejunum + [Term] id: UBERON:0018256 name: lacrimal vein @@ -300664,7 +418980,6 @@ xref: FMA:45634 xref: http://linkedlifedata.com/resource/umls/id/C0225358 xref: NCIT:C75444 xref: UMLS:C0225358 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -300684,9 +418999,20 @@ synonym: "tunica muscularis of digestive tract" EXACT [] is_a: UBERON:0006660 ! muscular coat intersection_of: UBERON:0006660 ! muscular coat intersection_of: part_of UBERON:0001555 ! digestive tract +relationship: capable_of_part_of GO:0030432 ! peristalsis relationship: part_of UBERON:0001555 ! digestive tract property_value: UBPROP:0000009 "responsible for gut movement, such as peristalsis" xsd:string +[Term] +id: UBERON:0018303 +name: adrenal tissue +is_a: UBERON:0000479 ! tissue +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000479 ! tissue +intersection_of: part_of UBERON:0002369 ! adrenal gland +relationship: part_of UBERON:0002369 ! adrenal gland + [Term] id: UBERON:0018321 name: foramen for glossopharyngeal nerve @@ -300699,6 +419025,18 @@ intersection_of: conduit_for UBERON:0001649 ! glossopharyngeal nerve relationship: conduit_for UBERON:0001649 ! glossopharyngeal nerve relationship: part_of UBERON:0003128 ! cranium +[Term] +id: UBERON:0018326 +name: ilioischiadic foramen +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005744 ! bone foramen +intersection_of: UBERON:0005744 ! bone foramen +intersection_of: conduit_for UBERON:0001322 ! sciatic nerve +relationship: adjacent_to UBERON:0001273 ! ilium +relationship: adjacent_to UBERON:0001274 ! ischium +relationship: conduit_for UBERON:0001322 ! sciatic nerve +relationship: part_of UBERON:0007832 ! pelvic girdle skeleton + [Term] id: UBERON:0018376 name: molar tooth 1 @@ -300730,7 +419068,6 @@ name: chemoreceptor namespace: uberon def: "A sensory receptor that detects chemical stimulus within the body." [http://orcid.org/0000-0002-6601-2165] xref: FMA:85604 -xref: MESH:A08.800.550.700.120 is_a: UBERON:0018389 {source="FMA"} ! interoceptor property_value: UBPROP:0000001 "Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." xsd:string {source="MESH:A08.800.550.700.120"} @@ -300756,6 +419093,34 @@ xref: SCTID:280360008 xref: Wikipedia:Infraorbital_nerve is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0022298 ! lower eyelid nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: branching_part_of UBERON:0000377 ! maxillary nerve +intersection_of: innervates UBERON:0000402 ! nasal vestibule +intersection_of: innervates UBERON:0001713 ! lower eyelid +intersection_of: innervates UBERON:0001834 ! upper lip +intersection_of: innervates UBERON:0011601 ! gingiva of upper jaw +relationship: branching_part_of UBERON:0000377 ! maxillary nerve +relationship: innervates UBERON:0000402 ! nasal vestibule +relationship: innervates UBERON:0001834 ! upper lip +relationship: innervates UBERON:0011601 ! gingiva of upper jaw + +[Term] +id: UBERON:0018413 +name: facial nerve canal +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: conduit_for UBERON:0001647 ! facial nerve +relationship: conduit_for UBERON:0001647 ! facial nerve +relationship: part_of UBERON:0001678 ! temporal bone + +[Term] +id: UBERON:0018415 +name: ethmoid foramen +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: part_of UBERON:0001679 ! ethmoid bone +relationship: part_of UBERON:0001679 ! ethmoid bone [Term] id: UBERON:0018543 @@ -300786,6 +419151,7 @@ def: "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." [MFMO:000007 synonym: "muscle innervated by the trigeminal nerve" EXACT [] synonym: "muscles innervated by the trigeminal nerve" EXACT PLURAL [MFMO:0000072] xref: MFMO:0000072 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0001630 ! muscle organ @@ -301087,6 +419453,26 @@ synonym: "bone neck" EXACT [] synonym: "neck of bone" EXACT [] is_a: UBERON:0001560 ! neck of organ is_a: UBERON:0005913 {notes="https://github.com/obophenotype/uberon/wiki/Hidden-GCIs"} ! zone of bone organ +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0001474 ! bone element + +[Term] +id: UBERON:0018667 +name: neck of scapula +is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0006849 ! scapula +relationship: part_of UBERON:0006849 ! scapula + +[Term] +id: UBERON:0018673 +name: neck of fibula +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005055 ! zone of long bone +is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0001446 ! fibula +relationship: part_of UBERON:0001446 ! fibula [Term] id: UBERON:0018674 @@ -301103,6 +419489,26 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart +[Term] +id: UBERON:0018691 +name: ventral side of post-anal tail +is_a: UBERON:0034929 ! external soft tissue zone +intersection_of: UBERON:0034929 ! external soft tissue zone +intersection_of: BSPO:0015102 UBERON:0007812 ! post-anal tail +relationship: BSPO:0015102 UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0013235 ! ventrum + +[Term] +id: UBERON:0018692 +name: dorsal side of post-anal tail +is_a: UBERON:0034929 ! external soft tissue zone +intersection_of: UBERON:0034929 ! external soft tissue zone +intersection_of: BSPO:0015101 UBERON:0007812 ! post-anal tail +relationship: BSPO:0015101 UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0001137 ! dorsum +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:0018707 name: bladder organ @@ -301112,6 +419518,7 @@ synonym: "bladder" NARROW [BTO:0000123] xref: BTO:0000123 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0009856 ! sac +relationship: has_quality PATO:0002468 ! distensible relationship: location_of UBERON:0000463 ! organism substance [Term] @@ -301149,6 +419556,32 @@ intersection_of: UBERON:0001986 ! endothelium intersection_of: part_of UBERON:0005396 ! carotid artery segment relationship: part_of UBERON:0005396 ! carotid artery segment +[Term] +id: UBERON:0019190 +name: mucous gland of lung +namespace: uberon +synonym: "bronchial gland" EXACT [FMA:13119] +synonym: "bronchial mucous gland" EXACT [FMA:13119] +synonym: "peribronchial gland" EXACT [BTO:0004638] +xref: BTO:0004638 +xref: FMA:13119 +xref: SCTID:88410004 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: part_of UBERON:0002048 ! lung +relationship: part_of UBERON:0002048 ! lung + +[Term] +id: UBERON:0019196 +name: iliac artery endothelium +is_a: UBERON:0001917 ! endothelium of artery +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:0005609 ! iliac artery +relationship: part_of UBERON:0005609 ! iliac artery + [Term] id: UBERON:0019204 name: skin epithelium @@ -301185,7 +419618,6 @@ synonym: "retinachoroid" EXACT [] synonym: "retinachoroidal region" EXACT [] xref: http://www.snomedbrowser.com/Codes/Details/110701000 xref: SCTID:110701000 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -301216,6 +419648,8 @@ synonym: "lateral digit" RELATED HUMAN_PREFERRED [] synonym: "outer digit" RELATED HUMAN_PREFERRED [] synonym: "outermost digit" RELATED HUMAN_PREFERRED [] is_a: UBERON:0002544 ! digit +union_of: UBERON:0006048 ! digit 1 +union_of: UBERON:0006052 ! digit 5 property_value: seeAlso https://github.com/obophenotype/uberon/issues/592 xsd:anyURI [Term] @@ -301239,6 +419673,8 @@ synonym: "outer manual digit" RELATED HUMAN_PREFERRED [] synonym: "outermost manual digit" RELATED HUMAN_PREFERRED [] is_a: UBERON:0002389 ! manual digit is_a: UBERON:0019221 ! digit 1 or 5 +union_of: UBERON:0001463 ! manual digit 1 +union_of: UBERON:0003625 ! manual digit 5 property_value: seeAlso https://github.com/obophenotype/uberon/issues/592 xsd:anyURI [Term] @@ -301263,6 +419699,8 @@ synonym: "outer pedal digit" RELATED HUMAN_PREFERRED [] synonym: "outermost pedal digit" RELATED HUMAN_PREFERRED [] is_a: UBERON:0001466 ! pedal digit is_a: UBERON:0019221 ! digit 1 or 5 +union_of: UBERON:0003631 ! pedal digit 1 +union_of: UBERON:0003635 ! pedal digit 5 property_value: seeAlso https://github.com/obophenotype/uberon/issues/592 xsd:anyURI [Term] @@ -301346,24 +419784,28 @@ id: UBERON:0019258 name: white matter of hindbrain namespace: uberon def: "A white matter that is part of the hindbrain." [OBOL:automatic] +subset: human_reference_atlas xref: DHBA:10668 xref: FMA:268636 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019261 name: white matter of forebrain namespace: uberon def: "A white matter that is part of the forebrain." [OBOL:automatic] +subset: human_reference_atlas xref: DHBA:10557 xref: FMA:268634 is_a: UBERON:0003544 ! brain white matter intersection_of: UBERON:0002316 ! white matter intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019262 @@ -301381,6 +419823,7 @@ relationship: part_of UBERON:0005290 ! myelencephalon id: UBERON:0019263 name: gray matter of hindbrain namespace: uberon +subset: human_reference_atlas synonym: "gray matter of the hindbrain" EXACT [DHBA:HGM] xref: DHBA:10654 xref: FMA:268630 @@ -301388,28 +419831,33 @@ is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0002028 ! hindbrain relationship: part_of UBERON:0002028 ! hindbrain +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019264 name: gray matter of forebrain namespace: uberon +subset: human_reference_atlas xref: DHBA:10157 xref: FMA:268608 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0001890 ! forebrain relationship: part_of UBERON:0001890 ! forebrain +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019267 name: gray matter of midbrain namespace: uberon +subset: human_reference_atlas xref: DHBA:10649 xref: FMA:83913 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: part_of UBERON:0001891 ! midbrain relationship: part_of UBERON:0001891 ! midbrain +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019269 @@ -301468,6 +419916,8 @@ namespace: uberon synonym: "telencephalic commissures" EXACT [HBA:TELCom] xref: HBA:9220 is_a: UBERON:0005970 ! brain commissure +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon [Term] @@ -301489,8 +419939,31 @@ xref: EMAPA:35958 xref: MA:0003171 is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0019304 ! sensory organ epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000004 ! nose relationship: part_of UBERON:0000004 ! nose +[Term] +id: UBERON:0019307 +name: epithelium of external nose +is_a: UBERON:0012329 ! keratinized stratified squamous epithelium +is_a: UBERON:0019306 ! nose epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0007827 ! external nose +relationship: part_of UBERON:0007827 ! external nose + +[Term] +id: UBERON:0019315 +name: meibum +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0001866 ! sebum +intersection_of: UBERON:0001866 ! sebum +intersection_of: produced_by UBERON:0001818 ! tarsal gland +relationship: adjacent_to UBERON:0010230 ! eyeball of camera-type eye +relationship: part_of UBERON:0000019 ! camera-type eye +relationship: produced_by UBERON:0001818 ! tarsal gland +relationship: surrounds UBERON:0022287 ! tear film + [Term] id: UBERON:0019319 name: exocrine gland of integumental system @@ -301519,12 +419992,20 @@ synonym: "nucleus of the spinal accessory nerve" RELATED [NeuroNames:2003] synonym: "spinal accessory nucleus" RELATED [http://orcid.org/0000-0002-6601-2165] xref: EMAPA:37067 {source="MA:th"} xref: FMA:83965 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2003 xref: MA:0001033 +xref: neuronames:2003 xref: Wikipedia:Spinal_accessory_nucleus is_a: UBERON:0000126 {source="FMA"} ! cranial nerve nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata +[Term] +id: UBERON:0020550 +name: auricular blood vessel +is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: connected_to UBERON:0001690 ! ear +relationship: connected_to UBERON:0001690 ! ear + [Term] id: UBERON:0022248 name: cerebral nerve fasciculus @@ -301540,6 +420021,14 @@ intersection_of: UBERON:0001019 ! nerve fasciculus intersection_of: part_of UBERON:0001893 ! telencephalon relationship: part_of UBERON:0001893 ! telencephalon +[Term] +id: UBERON:0022279 +name: strand of hair on external ear +is_a: UBERON:0016446 ! hair of head +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0001691 ! external ear +relationship: part_of UBERON:0001691 ! external ear + [Term] id: UBERON:0022284 name: lacrimal gland bud @@ -301552,6 +420041,18 @@ is_a: UBERON:0015808 ! eye epithelium relationship: part_of UBERON:0001750 ! lacrimal apparatus property_value: UBPROP:0000008 "in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; between E15.5 and E16.5 the bud undergoes branching morphogenesis, forming both a major extra-orbital lobe and a minor intraorbital lobe" xsd:string +[Term] +id: UBERON:0022287 +name: tear film +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +relationship: composed_primarily_of UBERON:0001827 ! secretion of lacrimal gland +relationship: has_quality PATO:0001735 ! liquid configuration +relationship: part_of UBERON:0001801 ! anterior segment of eyeball +relationship: part_of UBERON:0010409 ! ocular surface region +relationship: protects UBERON:0010409 ! ocular surface region + [Term] id: UBERON:0022288 name: surface of eyeball @@ -301573,6 +420074,8 @@ xref: NCIT:C33596 xref: SCTID:282511007 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] @@ -301585,7 +420088,6 @@ synonym: "genital secretion" RELATED [] synonym: "reproductive system fluid" RELATED [] synonym: "reproductive system fluid/secretion" RELATED [] synonym: "reproductive system secretion" RELATED [] -is_a: BFO:0000040 ! material entity is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: produced_by UBERON:0003937 ! reproductive gland @@ -301597,6 +420099,17 @@ name: lower eyelid nerve namespace: uberon def: "A nerve that innervates a lower eyelid." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003437 ! eyelid nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0001713 ! lower eyelid +relationship: innervates UBERON:0001713 ! lower eyelid + +[Term] +id: UBERON:0022299 +name: upper eyelid nerve +is_a: UBERON:0003437 ! eyelid nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0001712 ! upper eyelid +relationship: innervates UBERON:0001712 ! upper eyelid [Term] id: UBERON:0022303 @@ -301648,6 +420161,59 @@ intersection_of: part_of UBERON:0000042 ! serous membrane relationship: adjacent_to UBERON:0002553 ! anatomical cavity relationship: part_of UBERON:0000042 ! serous membrane +[Term] +id: UBERON:0022355 +name: basal layer of endometrium +namespace: uberon +def: "The layer of endometrial epithelium adjacent to the uterine cavity." [Wikipedia:Endometrium#Histology] +subset: human_reference_atlas +synonym: "pars basalis of endometrium" EXACT [] +synonym: "stratum basalis of endometrium" EXACT [FMA:86492] +xref: FMA:86492 +xref: NCIT:C32189 +is_a: UBERON:0004811 ! endometrium epithelium +intersection_of: UBERON:0004811 ! endometrium epithelium +intersection_of: adjacent_to UBERON:0013769 ! uterine lumen +relationship: adjacent_to UBERON:0013769 ! uterine lumen +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0022356 +name: outer layer of endometrium +is_a: UBERON:0004811 ! endometrium epithelium +intersection_of: UBERON:0004811 ! endometrium epithelium +intersection_of: adjacent_to UBERON:0001296 ! myometrium +relationship: adjacent_to UBERON:0001296 ! myometrium + +[Term] +id: UBERON:0022357 +name: mesentery of ileum +is_a: UBERON:0001170 ! mesentery of small intestine +intersection_of: UBERON:0002095 ! mesentery +intersection_of: part_of UBERON:0002116 ! ileum +relationship: part_of UBERON:0002116 ! ileum + +[Term] +id: UBERON:0022358 +name: placenta blood vessel +namespace: uberon +def: "A blood vessel of the placenta." [GO:0060674] +synonym: "placental vessel" BROAD [] +xref: SCTID:280716005 +is_a: UBERON:0001981 ! blood vessel +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: part_of UBERON:0001987 ! placenta +relationship: part_of UBERON:0001987 ! placenta + +[Term] +id: UBERON:0022360 +name: male mammary gland duct +is_a: UBERON:0001765 ! mammary duct +intersection_of: UBERON:0001765 ! mammary duct +intersection_of: part_of UBERON:0003101 ! male organism +relationship: part_of UBERON:0003101 ! male organism + [Term] id: UBERON:0022361 name: lung field @@ -301674,6 +420240,14 @@ is_a: UBERON:0011216 ! organ system subdivision relationship: part_of UBERON:0001016 ! nervous system property_value: editor_note "this class was inherited from NIFSTD as part of the replacement of NIFSTD with Uberon. It may be obsoleted in the future" xsd:string +[Term] +id: UBERON:0024045 +name: white matter of the cerebellar cortex +is_a: UBERON:0019291 ! white matter of metencephalon +intersection_of: UBERON:0002316 ! white matter +intersection_of: part_of UBERON:0002129 ! cerebellar cortex +relationship: part_of UBERON:0002129 ! cerebellar cortex + [Term] id: UBERON:0025261 name: thalamic fiber tract @@ -301682,6 +420256,8 @@ synonym: "thalamic fiber tracts" EXACT [BIRNLEX:749] synonym: "thalamic fiber tracts" EXACT HUMAN_PREFERRED [BIRNLEX:749] xref: BIRNLEX:749 is_a: UBERON:0011591 ! tract of diencephalon +intersection_of: UBERON:0001018 ! axon tract +intersection_of: part_of UBERON:0001897 ! dorsal plus ventral thalamus relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus [Term] @@ -301694,6 +420270,22 @@ synonym: "motor system" EXACT [NLXANAT:090805] xref: NLXANAT:090805 is_a: UBERON:0023879 {source="NIFSTD"} ! neural system +[Term] +id: UBERON:0026246 +name: sacral spinal cord white matter +is_a: UBERON:0002318 ! white matter of spinal cord +intersection_of: UBERON:0002316 ! white matter +intersection_of: part_of UBERON:0005843 ! sacral spinal cord +relationship: part_of UBERON:0005843 ! sacral spinal cord + +[Term] +id: UBERON:0026386 +name: lumbar spinal cord white matter +is_a: UBERON:0002318 ! white matter of spinal cord +intersection_of: UBERON:0002316 ! white matter +intersection_of: part_of UBERON:0002792 ! lumbar spinal cord +relationship: part_of UBERON:0002792 ! lumbar spinal cord + [Term] id: UBERON:0027331 name: flocculonodular lobe, hemisphere portion @@ -301704,12 +420296,58 @@ is_a: UBERON:0002749 ! regional part of cerebellar cortex relationship: part_of UBERON:0002245 ! cerebellar hemisphere relationship: part_of UBERON:0003012 ! flocculonodular lobe +[Term] +id: UBERON:0029503 +name: sacral spinal cord gray matter +is_a: UBERON:0002315 ! gray matter of spinal cord +intersection_of: UBERON:0002020 ! gray matter +intersection_of: part_of UBERON:0005843 ! sacral spinal cord +relationship: part_of UBERON:0005843 ! sacral spinal cord + +[Term] +id: UBERON:0029636 +name: lumbar spinal cord gray matter +is_a: UBERON:0002315 ! gray matter of spinal cord +intersection_of: UBERON:0002020 ! gray matter +intersection_of: part_of UBERON:0002792 ! lumbar spinal cord +relationship: part_of UBERON:0002792 ! lumbar spinal cord + +[Term] +id: UBERON:0030276 +name: lumbar spinal cord ventral horn +is_a: UBERON:0002257 ! ventral horn of spinal cord +intersection_of: UBERON:0002257 ! ventral horn of spinal cord +intersection_of: part_of UBERON:0002792 ! lumbar spinal cord +relationship: part_of UBERON:0029636 ! lumbar spinal cord gray matter + +[Term] +id: UBERON:0032748 +name: sacral spinal cord ventral horn +is_a: UBERON:0002257 ! ventral horn of spinal cord +intersection_of: UBERON:0002257 ! ventral horn of spinal cord +intersection_of: part_of UBERON:0005843 ! sacral spinal cord +relationship: part_of UBERON:0029503 ! sacral spinal cord gray matter + +[Term] +id: UBERON:0034670 +name: palatal taste bud +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013765 ! digestive system element +is_a: UBERON:0034722 ! mouth roof taste bud +intersection_of: UBERON:0001727 ! taste bud +intersection_of: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0001733 ! soft palate +relationship: part_of UBERON:0014453 ! gustatory epithelium of palate + [Term] id: UBERON:0034681 name: vocal organ namespace: uberon def: "Any organ that is the primary organ of vocalization behavior. Examples: The laryngeal vocal cord (humans), the syrinx (birds)." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000062 ! organ +intersection_of: UBERON:0000062 ! organ +intersection_of: capable_of_part_of GO:0071625 ! vocalization behavior +relationship: capable_of_part_of GO:0071625 ! vocalization behavior [Term] id: UBERON:0034696 @@ -301755,6 +420393,14 @@ xref: AEO:0001010 is_a: UBERON:0034705 {source="AEO"} ! developing neuroepithelium relationship: has_part CL:0000031 ! neuroblast (sensu Vertebrata) +[Term] +id: UBERON:0034708 +name: cerebellum marginal layer +is_a: UBERON:0034709 ! hindbrain marginal layer +intersection_of: UBERON:0004062 ! neural tube marginal layer +intersection_of: part_of UBERON:0002037 ! cerebellum +relationship: part_of UBERON:0002037 ! cerebellum + [Term] id: UBERON:0034709 name: hindbrain marginal layer @@ -301804,6 +420450,29 @@ relationship: extends_fibers_into UBERON:0000955 ! brain relationship: in_lateral_side_of UBERON:0000033 ! head relationship: only_in_taxon NCBITaxon:89593 ! Craniata +[Term] +id: UBERON:0034714 +name: epiphyseal tract +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0011215 ! central nervous system cell part cluster +is_a: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: innervates UBERON:0004869 ! parietal organ +relationship: extends_fibers_into UBERON:0001899 ! epithalamus +relationship: innervates UBERON:0004869 ! parietal organ + +[Term] +id: UBERON:0034715 +name: pineal tract +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0011215 ! central nervous system cell part cluster +is_a: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: UBERON:0034713 ! cranial neuron projection bundle +intersection_of: innervates UBERON:0001905 ! pineal body +relationship: branching_part_of UBERON:0034714 ! epiphyseal tract +relationship: extends_fibers_into UBERON:0001899 ! epithalamus +relationship: innervates UBERON:0001905 ! pineal body + [Term] id: UBERON:0034717 name: integumental taste bud @@ -301849,6 +420518,14 @@ intersection_of: part_of UBERON:0006562 ! pharynx relationship: part_of UBERON:0000355 ! pharyngeal mucosa property_value: RO:0002175 NCBITaxon:7778 +[Term] +id: UBERON:0034722 +name: mouth roof taste bud +is_a: UBERON:0001727 ! taste bud +intersection_of: UBERON:0001727 ! taste bud +intersection_of: part_of UBERON:0007375 ! roof of mouth +relationship: part_of UBERON:0007375 ! roof of mouth + [Term] id: UBERON:0034724 name: esophageal taste bud @@ -301895,6 +420572,7 @@ relationship: part_of UBERON:0002410 ! autonomic nervous system id: UBERON:0034729 name: sympathetic nerve namespace: uberon +subset: human_reference_atlas xref: EMAPA:37958 {source="MA:th"} xref: SCTID:181098007 is_a: UBERON:0001021 ! nerve @@ -301902,6 +420580,34 @@ intersection_of: UBERON:0001021 ! nerve intersection_of: part_of UBERON:0000013 ! sympathetic nervous system relationship: extends_fibers_into UBERON:0001806 ! sympathetic ganglion relationship: part_of UBERON:0000013 ! sympathetic nervous system +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0034730 +name: olfactory tract linking bulb to ipsilateral dorsal telencephalon +is_a: UBERON:0002265 ! olfactory tract +intersection_of: UBERON:0002265 ! olfactory tract +intersection_of: overlaps UBERON:0000203 ! pallium +relationship: overlaps UBERON:0000203 ! pallium + +[Term] +id: UBERON:0034736 +name: coracoclavicular ligament +is_a: UBERON:0008846 ! skeletal ligament +intersection_of: UBERON:0008846 ! skeletal ligament +intersection_of: connects UBERON:0001105 ! clavicle bone +intersection_of: connects UBERON:0006633 ! coracoid process of scapula +relationship: connects UBERON:0001105 ! clavicle bone +relationship: connects UBERON:0006633 ! coracoid process of scapula +relationship: part_of UBERON:0003692 ! acromioclavicular joint + +[Term] +id: UBERON:0034763 +name: hindbrain commissure +is_a: UBERON:0005970 ! brain commissure +intersection_of: UBERON:0001020 ! nervous system commissure +intersection_of: part_of UBERON:0002028 ! hindbrain +relationship: part_of UBERON:0002028 ! hindbrain [Term] id: UBERON:0034766 @@ -301920,6 +420626,7 @@ name: morphological feature namespace: uberon def: "A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure +relationship: has_quality PATO:0000052 ! shape relationship: part_of UBERON:0000468 ! multicellular organism [Term] @@ -301930,6 +420637,16 @@ xref: FMA:79770 xref: NCIT:C41168 is_a: UBERON:0015757 {source="FMA"} ! heterogeneous tissue +[Term] +id: UBERON:0034770 +name: bulbourethral gland epithelium +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0016510 ! epithelium of male urethra +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002366 ! bulbo-urethral gland +relationship: part_of UBERON:0002366 ! bulbo-urethral gland + [Term] id: UBERON:0034772 name: margin of eyelid @@ -301978,20 +420695,25 @@ synonym: "pituitary primordium" EXACT [EHDAA2:0001472] xref: EHDAA2:0001472 xref: EMAPA:32796 is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0006598 ! presumptive structure +intersection_of: has_potential_to_develop_into UBERON:0000007 ! pituitary gland relationship: develops_from UBERON:0000924 {source="Wikipedia"} ! ectoderm +relationship: has_potential_to_develop_into UBERON:0000007 ! pituitary gland relationship: part_of UBERON:0000033 {source="EMAPA"} ! head [Term] id: UBERON:0034876 name: future neurohypophysis namespace: uberon -alt_id: EMAPA:16647 def: "The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland." [https://sourceforge.net/p/obo/mammalian-phenotype-requests/1930/, MP:0013339] synonym: "neurohypohysial region" RELATED [EHDAA2:0004434] synonym: "neurohypophyseal bud" RELATED [MP:0013339] xref: EHDAA2:0004434 xref: EMAPA:16647 is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0006598 ! presumptive structure +intersection_of: has_potential_to_develop_into UBERON:0002198 ! neurohypophysis +relationship: has_potential_to_develop_into UBERON:0002198 ! neurohypophysis relationship: part_of UBERON:0001894 {source="EMAPA"} ! diencephalon relationship: part_of UBERON:0034875 {source="EMAPA"} ! future pituitary gland @@ -302010,6 +420732,14 @@ intersection_of: part_of UBERON:0003068 ! axial mesoderm relationship: has_potential_to_develop_into UBERON:0003063 ! prechordal plate relationship: part_of UBERON:0003068 ! axial mesoderm +[Term] +id: UBERON:0034898 +name: alveolar ridge of premaxilla +is_a: UBERON:0004103 ! alveolar ridge +intersection_of: UBERON:0004103 ! alveolar ridge +intersection_of: part_of UBERON:0002244 ! premaxilla +relationship: part_of UBERON:0002244 ! premaxilla + [Term] id: UBERON:0034903 name: left atrium endocardium @@ -302039,12 +420769,34 @@ intersection_of: luminal_space_of UBERON:0002530 ! gland relationship: luminal_space_of UBERON:0002530 ! gland relationship: part_of UBERON:0002530 ! gland +[Term] +id: UBERON:0034907 +name: pineal parenchyma +is_a: UBERON:0005158 ! parenchyma of central nervous system +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001905 ! pineal body +relationship: part_of UBERON:0001905 ! pineal body + [Term] id: UBERON:0034908 name: scapular muscle namespace: uberon def: "Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle." [HPO:curators] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0014892 ! skeletal muscle organ +intersection_of: UBERON:0014892 ! skeletal muscle organ +intersection_of: attaches_to UBERON:0006849 ! scapula +relationship: attaches_to UBERON:0006849 ! scapula + +[Term] +id: UBERON:0034909 +name: intermaxillary suture +is_a: UBERON:0003685 ! cranial suture +is_a: UBERON:0009199 ! facial suture +intersection_of: UBERON:0003685 ! cranial suture +intersection_of: connects UBERON:0002397 {cardinality="2"} ! maxilla +relationship: connects UBERON:0002397 ! maxilla +relationship: part_of UBERON:0001709 ! upper jaw region [Term] id: UBERON:0034921 @@ -302053,7 +420805,6 @@ namespace: uberon def: "An multicellular anatomical structure that has subparts of multiple organs as a part." [CARO:0020001] synonym: "anatomical cluster" RELATED [CARO:0020001] xref: CARO:0020001 -is_a: BFO:0000040 ! material entity is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure relationship: composed_primarily_of UBERON:0000064 ! organ part @@ -302073,7 +420824,11 @@ name: disconnected anatomical group namespace: uberon def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." [CARO:0020000] xref: CARO:0020000 +xref: FBbt:00007276 is_a: UBERON:0000465 {source="CARO"} ! material anatomical entity +relationship: composed_primarily_of UBERON:0000061 ! anatomical structure +relationship: has_component UBERON:0000061 {minCardinality="2"} ! anatomical structure +relationship: has_quality PATO:0010001 ! disconnected [Term] id: UBERON:0034925 @@ -302093,12 +420848,21 @@ xref: FBbt:00100152 is_a: UBERON:0034925 ! anatomical collection property_value: editor_note "resolve if this should be a subclass of or merged with aligned anatomical group." xsd:string +[Term] +id: UBERON:0034928 +name: dorsal surface of penis +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0036215 ! anatomical surface region +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: BSPO:0015101 UBERON:0000989 ! penis +relationship: BSPO:0015101 UBERON:0000989 ! penis +relationship: part_of UBERON:0000989 ! penis + [Term] id: UBERON:0034929 name: external soft tissue zone namespace: uberon def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." [http://orcid.org/0000-0002-6601-2165] -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0010000 ! multicellular anatomical structure relationship: has_part UBERON:0000014 ! zone of skin @@ -302117,6 +420881,8 @@ synonym: "biliary system epithelium" EXACT [http://orcid.org/0000-0002-6601-2165 synonym: "biliary tract epithelium" RELATED [http://orcid.org/0000-0002-6601-2165] xref: BTO:0001513 is_a: UBERON:0000483 ! epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0002294 ! biliary system relationship: part_of UBERON:0002294 ! biliary system [Term] @@ -302129,6 +420895,14 @@ intersection_of: UBERON:0004923 ! organ component layer intersection_of: composed_primarily_of UBERON:0001135 ! smooth muscle tissue relationship: composed_primarily_of UBERON:0001135 ! smooth muscle tissue +[Term] +id: UBERON:0034940 +name: venous sinus cavity +is_a: UBERON:0010161 ! lumen of blood vessel +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0006615 ! venous sinus +relationship: luminal_space_of UBERON:0006615 ! venous sinus + [Term] id: UBERON:0034944 name: zone of organ @@ -302140,6 +420914,31 @@ synonym: "organ zone" EXACT [FMA:55268] xref: FMA:55268 is_a: UBERON:0000064 ! organ part +[Term] +id: UBERON:0034945 +name: excreted gas +namespace: uberon +def: "Any gaseous product of an excretory process." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000174 ! excreta +is_a: UBERON:0034873 ! bodily gas +intersection_of: UBERON:0034873 ! bodily gas +intersection_of: output_of GO:0007588 ! excretion + +[Term] +id: UBERON:0034946 +name: gas excreted from digestive tract +namespace: uberon +def: "Any excreted gas that is produced by the digestive tract." [http://orcid.org/0000-0002-6601-2165] +comment: In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum +synonym: "flatulence" NARROW [FMA:78440] +synonym: "flatus" NARROW LATIN [Wikipedia:Flatulence] +synonym: "intestinal gas" NARROW [] +xref: FMA:78440 +is_a: UBERON:0034945 ! excreted gas +intersection_of: UBERON:0034945 ! excreted gas +intersection_of: produced_by UBERON:0001555 ! digestive tract +relationship: produced_by UBERON:0001555 ! digestive tract + [Term] id: UBERON:0034947 name: gas in respiratory system @@ -302147,7 +420946,6 @@ namespace: uberon def: "Any portion of gas located in a part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] synonym: "respiratory gas" EXACT [] synonym: "respiratory system gas" EXACT [] -is_a: BFO:0000040 ! material entity is_a: UBERON:0034873 ! bodily gas intersection_of: UBERON:0034873 ! bodily gas intersection_of: located_in UBERON:0001004 ! respiratory system @@ -302179,6 +420977,13 @@ intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0000058 ! duct relationship: part_of UBERON:0000058 ! duct +[Term] +id: UBERON:0034972 +name: jugular body +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0034979 ! nonchromaffin paraganglion +relationship: part_of UBERON:0034980 ! jugular bulb + [Term] id: UBERON:0034978 name: paraganglion (generic) @@ -302190,6 +420995,7 @@ xref: SCTID:281695005 xref: Wikipedia:Paraganglion is_a: UBERON:0010001 {source="cjm"} ! cell cluster organ is_a: UBERON:0010313 ! neural crest-derived structure +relationship: composed_primarily_of CL:0000165 ! neuroendocrine cell property_value: editor_note "corresponding portion of CL needs fixed" xsd:string [Term] @@ -302197,8 +421003,16 @@ id: UBERON:0034979 name: nonchromaffin paraganglion namespace: uberon def: "A cluster of chemoreceptive and support cells associated with blood vessels and nerves." [MESH:A08.800.550.700.120.600, Wikipedia:Paraganglion] -xref: MESH:A08.800.550.700.120.600 +xref: MESH:D010234 is_a: UBERON:0034978 ! paraganglion (generic) +relationship: capable_of GO:0009593 ! detection of chemical stimulus + +[Term] +id: UBERON:0034980 +name: jugular bulb +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0013522 ! subdivision of tube +relationship: part_of UBERON:0001586 ! internal jugular vein [Term] id: UBERON:0034994 @@ -302225,6 +421039,14 @@ intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0011595 ! jaw region relationship: part_of UBERON:0011595 ! jaw region +[Term] +id: UBERON:0034996 +name: outer renal medulla loop of Henle +is_a: UBERON:0034997 ! renal medulla loop of Henle +intersection_of: UBERON:0001288 ! loop of Henle +intersection_of: part_of UBERON:0001293 ! outer medulla of kidney +relationship: part_of UBERON:0001293 ! outer medulla of kidney + [Term] id: UBERON:0034997 name: renal medulla loop of Henle @@ -302233,6 +421055,8 @@ synonym: "loop of Henle of renal medulla" EXACT [EMAPA:35460] synonym: "loop of Henle, medullary portion" EXACT [] xref: EMAPA:35460 is_a: UBERON:0001288 ! loop of Henle +intersection_of: UBERON:0001288 ! loop of Henle +intersection_of: part_of UBERON:0000362 ! renal medulla relationship: part_of UBERON:0000362 ! renal medulla [Term] @@ -302251,8 +421075,18 @@ namespace: uberon synonym: "prepuce of male" RELATED [EMAPA:29220] xref: EMAPA:29220 is_a: UBERON:0035004 ! preputial swelling +intersection_of: UBERON:0035004 ! preputial swelling +intersection_of: part_of UBERON:0003101 ! male organism relationship: part_of UBERON:0006261 {source="EMAPA"} ! male genital tubercle +[Term] +id: UBERON:0035006 +name: preputial swelling of female +is_a: UBERON:0035004 ! preputial swelling +intersection_of: UBERON:0035004 ! preputial swelling +intersection_of: part_of UBERON:0003100 ! female organism +relationship: part_of UBERON:0006233 ! female genital tubercle + [Term] id: UBERON:0035007 name: nasal concha cartilage @@ -302282,11 +421116,27 @@ name: thermoreceptor namespace: uberon def: "Cellular receptors which mediate the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and NOCICEPTORS which detect cold or heat extreme enough to cause pain." [MESH:A08.800.550.700.840] synonym: "thermoreceptor" RELATED [MESH:A08.800.550.700.840] -xref: MESH:A08.800.550.700.840 +xref: MESH:D013823 xref: NCIT:C13822 xref: UMLS:C0039821 is_a: UBERON:0012451 ! sensory receptor +[Term] +id: UBERON:0035034 +name: eyelid epithelium +is_a: UBERON:0015808 ! eye epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0001711 ! eyelid +relationship: part_of UBERON:0001711 ! eyelid + +[Term] +id: UBERON:0035036 +name: naris epithelium +is_a: UBERON:0000483 ! epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: part_of UBERON:0000003 ! naris +relationship: part_of UBERON:0000003 ! naris + [Term] id: UBERON:0035037 name: jaw epithelium @@ -302305,6 +421155,19 @@ namespace: uberon synonym: "hemorrhoidal artery" EXACT [] xref: SCTID:277967008 is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001052 ! rectum +relationship: supplies UBERON:0001052 ! rectum + +[Term] +id: UBERON:0035045 +name: parotid gland intralobular duct +is_a: UBERON:0001837 ! duct of salivary gland +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0014719 ! intralobular duct +intersection_of: UBERON:0014719 ! intralobular duct +intersection_of: part_of UBERON:0001831 ! parotid gland +relationship: part_of UBERON:0001831 ! parotid gland [Term] id: UBERON:0035048 @@ -302313,6 +421176,8 @@ namespace: uberon def: "Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product." [MP:0013750] is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0035049 ! excretory duct of salivary gland +intersection_of: UBERON:0035050 ! excretory duct +intersection_of: part_of UBERON:0001831 ! parotid gland relationship: part_of UBERON:0001831 ! parotid gland [Term] @@ -302323,6 +421188,8 @@ def: "Any of the interlobular excretory ducts of a salivary gland which are foun xref: FMA:60052 is_a: UBERON:0001837 ! duct of salivary gland is_a: UBERON:0035050 ! excretory duct +intersection_of: UBERON:0035050 ! excretory duct +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland [Term] id: UBERON:0035050 @@ -302330,6 +421197,41 @@ name: excretory duct namespace: uberon is_a: UBERON:0000058 ! duct +[Term] +id: UBERON:0035053 +name: interlobular duct of salivary gland +is_a: UBERON:0014716 ! interlobular duct +is_a: UBERON:0035049 ! excretory duct of salivary gland +intersection_of: UBERON:0014716 ! interlobular duct +intersection_of: part_of UBERON:0001044 ! saliva-secreting gland + +[Term] +id: UBERON:0035073 +name: duct of eccrine sweat gland +is_a: UBERON:0000058 ! duct +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0000423 ! eccrine sweat gland +relationship: part_of UBERON:0000423 ! eccrine sweat gland + +[Term] +id: UBERON:0035074 +name: duct of apocrine sweat gland +is_a: UBERON:0000058 ! duct +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: part_of UBERON:0000382 ! apocrine sweat gland +relationship: part_of UBERON:0000382 ! apocrine sweat gland + +[Term] +id: UBERON:0035075 +name: thymus subunit +is_a: UBERON:0000063 ! organ subunit +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000063 ! organ subunit +intersection_of: part_of UBERON:0002046 ! thyroid gland +relationship: part_of UBERON:0002046 ! thyroid gland + [Term] id: UBERON:0035076 name: parotid gland myoepithelium @@ -302339,6 +421241,46 @@ xref: EMAPA:37934 {source="MA:th"} is_a: UBERON:0000420 ! myoepithelium is_a: UBERON:0003360 ! epithelium of parotid gland +[Term] +id: UBERON:0035078 +name: parotid gland interlobular duct +is_a: UBERON:0035048 ! parotid gland excretory duct +is_a: UBERON:0035053 ! interlobular duct of salivary gland +intersection_of: UBERON:0014716 ! interlobular duct +intersection_of: part_of UBERON:0001831 ! parotid gland + +[Term] +id: UBERON:0035083 +name: transverse process-bearing vertebra +is_a: UBERON:0002412 ! vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: has_part UBERON:0001077 ! transverse process of vertebra +relationship: has_part UBERON:0001077 ! transverse process of vertebra + +[Term] +id: UBERON:0035091 +name: extrinsic post-anal tail muscle +is_a: UBERON:0003665 ! post-anal tail muscle +intersection_of: UBERON:0003665 ! post-anal tail muscle +intersection_of: attaches_to UBERON:0010742 ! bone of pelvic complex +relationship: attaches_to UBERON:0010742 ! bone of pelvic complex + +[Term] +id: UBERON:0035096 +name: fascia of tail +is_a: UBERON:0003599 ! tail connective tissue +is_a: UBERON:0008982 ! fascia +intersection_of: UBERON:0008982 ! fascia +intersection_of: part_of UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0035102 +name: transverse process of caudal vertebra +is_a: UBERON:0001077 ! transverse process of vertebra +intersection_of: UBERON:0001077 ! transverse process of vertebra +intersection_of: part_of UBERON:0001095 ! caudal vertebra +relationship: part_of UBERON:0001095 ! caudal vertebra + [Term] id: UBERON:0035106 name: raphe of perineum @@ -302354,6 +421296,32 @@ is_a: UBERON:0034929 ! external soft tissue zone relationship: develops_from UBERON:0004876 {source="Wikipedia"} ! urogenital fold property_value: UBPROP:0000011 "It is the result of a fetal developmental phenomenon whereby the scrotum (the developmental equivalent of the labia in females) and penis close toward the midline and fuse. The resulting ridge of tissue is evident as the perineal raphe" xsd:string +[Term] +id: UBERON:0035109 +name: plantar nerve +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0003431 ! leg nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0008338 ! plantar part of pes +relationship: branching_part_of UBERON:0001323 ! tibial nerve +relationship: innervates UBERON:0008338 ! plantar part of pes + +[Term] +id: UBERON:0035110 +name: lateral plantar nerve +is_a: UBERON:0035109 ! plantar nerve +intersection_of: UBERON:0035109 ! plantar nerve +intersection_of: innervates UBERON:0003635 ! pedal digit 5 +relationship: innervates UBERON:0003635 ! pedal digit 5 + +[Term] +id: UBERON:0035111 +name: medial plantar nerve +is_a: UBERON:0035109 ! plantar nerve +intersection_of: UBERON:0035109 ! plantar nerve +intersection_of: innervates UBERON:0003631 ! pedal digit 1 +relationship: innervates UBERON:0003631 ! pedal digit 1 + [Term] id: UBERON:0035112 name: intrinsic muscle @@ -302390,7 +421358,6 @@ namespace: uberon def: "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." [https://github.com/EnvironmentOntology/envo/issues/110] synonym: "digestive tract contents" EXACT PLURAL [] synonym: "ingested material entity" RELATED [] -is_a: BFO:0000040 ! material entity is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: located_in UBERON:0006909 ! lumen of digestive tract @@ -302414,6 +421381,8 @@ def: "Any of the sutures of the hard palate." [http://www.merriam-webster.com/me synonym: "palatine suture" EXACT [http://www.merriam-webster.com/medical/palatine%20suture] is_a: UBERON:0003685 ! cranial suture is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0003685 ! cranial suture +intersection_of: part_of UBERON:0003216 ! hard palate relationship: part_of UBERON:0003216 ! hard palate [Term] @@ -302424,6 +421393,9 @@ synonym: "hand cartilage condensation" EXACT [EMAPA:32631] xref: EMAPA:32631 is_a: UBERON:0010883 ! forelimb cartilage element is_a: UBERON:0015064 ! autopod cartilage +intersection_of: UBERON:0015063 ! autopod endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +intersection_of: part_of UBERON:0002398 ! manus relationship: develops_from UBERON:0009523 {source="EMAPA-modified"} ! mesenchyme of handplate relationship: part_of UBERON:0002398 ! manus @@ -302435,6 +421407,9 @@ synonym: "foot cartilage condensation" EXACT [EMAPA:32657] xref: EMAPA:32657 is_a: UBERON:0010885 ! hindlimb cartilage element is_a: UBERON:0015064 ! autopod cartilage +intersection_of: UBERON:0015063 ! autopod endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue +intersection_of: part_of UBERON:0002387 ! pes relationship: develops_from UBERON:0003328 {source="EMAPA-modified"} ! mesenchyme of footplate relationship: part_of UBERON:0002387 ! pes @@ -302453,6 +421428,7 @@ synonym: "ossicle element of inner ear" RELATED [] synonym: "ossicular chain element" RELATED PLURAL [] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010363 ! endochondral element +relationship: contributes_to_morphology_of UBERON:0001756 ! middle ear relationship: develops_from UBERON:0003099 {source="PMID:11237469", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! cranial neural crest relationship: part_of UBERON:0001756 {source="MA"} ! middle ear relationship: part_of UBERON:0008895 {source="PMID:11523816"} ! splanchnocranium @@ -302465,6 +421441,8 @@ synonym: "ossicle cartilage condensation" EXACT [EMAPA:35979] xref: EMAPA:35979 is_a: UBERON:0011004 ! pharyngeal arch cartilage is_a: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0035132 @@ -302473,6 +421451,9 @@ namespace: uberon synonym: "ossicle pre-cartilage condensation" EXACT [EMAPA:35982] xref: EMAPA:35982 is_a: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: UBERON:0035130 ! auditory ossicle endochondral element +intersection_of: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation +relationship: composed_primarily_of UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0035133 @@ -302514,12 +421495,48 @@ xref: http://www.snomedbrowser.com/Codes/Details/261060002 xref: NCIT:C29667 xref: SCTID:261060002 xref: UMLS:C0489451 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: surrounds UBERON:0000468 ! multicellular organism relationship: surrounds UBERON:0000468 ! multicellular organism +[Term] +id: UBERON:0035165 +name: posterior surface of prostate +is_a: UBERON:0035480 ! surface of prostate +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: bounding_layer_of UBERON:0002367 ! prostate gland +intersection_of: in_posterior_side_of UBERON:0002367 ! prostate gland +relationship: in_posterior_side_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0035174 +name: right ear +is_a: UBERON:0001690 ! ear +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001690 ! ear +intersection_of: in_right_side_of UBERON:0000033 ! head +relationship: in_right_side_of UBERON:0000033 ! head + +[Term] +id: UBERON:0035198 +name: superficial lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0035549 ! vasculature of integument +relationship: part_of UBERON:0035549 ! vasculature of integument + +[Term] +id: UBERON:0035201 +name: gastrocolic ligament +is_a: UBERON:0034696 ! fold of peritoneum +intersection_of: UBERON:0034696 ! fold of peritoneum +intersection_of: connects UBERON:0000945 ! stomach +intersection_of: connects UBERON:0001157 ! transverse colon +relationship: connects UBERON:0000945 ! stomach +relationship: connects UBERON:0001157 ! transverse colon +relationship: part_of UBERON:0005448 ! greater omentum + [Term] id: UBERON:0035237 name: branch of internal carotid artery @@ -302537,6 +421554,47 @@ intersection_of: UBERON:0005396 ! carotid artery segment intersection_of: branching_part_of UBERON:0001532 ! internal carotid artery relationship: branching_part_of UBERON:0001532 ! internal carotid artery +[Term] +id: UBERON:0035240 +name: posterior wall of oropharynx +is_a: UBERON:0000328 ! gut wall +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: in_posterior_side_of UBERON:0001729 ! oropharynx +intersection_of: part_of UBERON:0001729 ! oropharynx +relationship: in_posterior_side_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx + +[Term] +id: UBERON:0035267 +name: neck of gallbladder +is_a: UBERON:0001560 ! neck of organ +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 ! gall bladder + +[Term] +id: UBERON:0035286 +name: lateral wall of oropharynx +is_a: UBERON:0000328 ! gut wall +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: in_lateral_side_of UBERON:0001729 ! oropharynx +intersection_of: part_of UBERON:0001729 ! oropharynx +relationship: in_lateral_side_of UBERON:0001729 ! oropharynx +relationship: part_of UBERON:0001729 ! oropharynx + +[Term] +id: UBERON:0035295 +name: left ear +is_a: UBERON:0001690 ! ear +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001690 ! ear +intersection_of: in_left_side_of UBERON:0000033 ! head +relationship: in_left_side_of UBERON:0000033 ! head + [Term] id: UBERON:0035307 name: branch of vertebral artery @@ -302547,6 +421605,59 @@ xref: NCIT:C33867 xref: SCTID:360535000 xref: UMLS:C1185372 is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001535 ! vertebral artery +relationship: branching_part_of UBERON:0001535 ! vertebral artery + +[Term] +id: UBERON:0035313 +name: posterior wall of laryngopharynx +is_a: UBERON:0000328 ! gut wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: in_posterior_side_of UBERON:0001051 ! hypopharynx +intersection_of: part_of UBERON:0001051 ! hypopharynx +relationship: in_posterior_side_of UBERON:0001051 ! hypopharynx +relationship: part_of UBERON:0001051 ! hypopharynx + +[Term] +id: UBERON:0035316 +name: prostatic capsule +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003893 ! capsule +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0003893 ! capsule +intersection_of: part_of UBERON:0002367 ! prostate gland +relationship: part_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0035322 +name: right common iliac artery +is_a: UBERON:0001191 ! common iliac artery +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001191 ! common iliac artery +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0035371 +name: retroperitoneal lymph node +is_a: UBERON:0000029 ! lymph node +is_a: UBERON:0002075 ! viscus +intersection_of: UBERON:0000029 ! lymph node +intersection_of: located_in UBERON:0003693 ! retroperitoneal space +relationship: located_in UBERON:0003693 ! retroperitoneal space + +[Term] +id: UBERON:0035383 +name: lateral wall of nasopharynx +is_a: UBERON:0000328 ! gut wall +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: in_lateral_side_of UBERON:0001728 ! nasopharynx +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: in_lateral_side_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx [Term] id: UBERON:0035398 @@ -302564,6 +421675,42 @@ intersection_of: UBERON:0001637 ! artery intersection_of: branching_part_of UBERON:0001070 ! external carotid artery relationship: branching_part_of UBERON:0001070 ! external carotid artery +[Term] +id: UBERON:0035401 +name: posterior wall of nasopharynx +is_a: UBERON:0000328 ! gut wall +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: in_posterior_side_of UBERON:0001728 ! nasopharynx +intersection_of: part_of UBERON:0001728 ! nasopharynx +relationship: in_posterior_side_of UBERON:0001728 ! nasopharynx +relationship: part_of UBERON:0001728 ! nasopharynx + +[Term] +id: UBERON:0035403 +name: hypophysial artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0000007 ! pituitary gland +relationship: supplies UBERON:0000007 ! pituitary gland + +[Term] +id: UBERON:0035431 +name: mediastinal pleura +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0034944 ! zone of organ +relationship: has_part UBERON:0003728 ! mediastinum +relationship: part_of UBERON:0002400 ! parietal pleura + +[Term] +id: UBERON:0035435 +name: right suprarenal vein +is_a: UBERON:0001146 ! suprarenal vein +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001146 ! suprarenal vein +intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: in_right_side_of UBERON:0000468 ! multicellular organism + [Term] id: UBERON:0035471 name: posterior surface of kidney @@ -302583,11 +421730,89 @@ relationship: bounding_layer_of UBERON:0002113 ! kidney relationship: in_posterior_side_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney +[Term] +id: UBERON:0035480 +name: surface of prostate +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0036215 ! anatomical surface region +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: bounding_layer_of UBERON:0002367 ! prostate gland +relationship: bounding_layer_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0035483 +name: left suprarenal vein +is_a: UBERON:0001146 ! suprarenal vein +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001146 ! suprarenal vein +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + +[Term] +id: UBERON:0035489 +name: branch of basilar artery +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001633 ! basilar artery +relationship: branching_part_of UBERON:0001633 ! basilar artery + +[Term] +id: UBERON:0035498 +name: gastrophrenic ligament +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005172 ! abdomen element +is_a: UBERON:0008845 ! nonskeletal ligament +intersection_of: UBERON:0008845 ! nonskeletal ligament +intersection_of: connects UBERON:0001103 ! diaphragm +intersection_of: connects UBERON:0001164 ! greater curvature of stomach +intersection_of: part_of UBERON:0005448 ! greater omentum +relationship: connects UBERON:0001103 ! diaphragm +relationship: connects UBERON:0001164 ! greater curvature of stomach +relationship: part_of UBERON:0005448 ! greater omentum + +[Term] +id: UBERON:0035505 +name: right inguinal part of abdomen +is_a: UBERON:0008337 ! inguinal part of abdomen +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0008337 ! inguinal part of abdomen +intersection_of: in_right_side_of UBERON:0000916 ! abdomen +relationship: in_right_side_of UBERON:0000916 ! abdomen + +[Term] +id: UBERON:0035508 +name: branch of posterior cerebral artery +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: branching_part_of UBERON:0001636 ! posterior cerebral artery +relationship: branching_part_of UBERON:0001636 ! posterior cerebral artery + +[Term] +id: UBERON:0035523 +name: anterior surface of prostate +is_a: UBERON:0035480 ! surface of prostate +intersection_of: UBERON:0036215 ! anatomical surface region +intersection_of: bounding_layer_of UBERON:0002367 ! prostate gland +intersection_of: in_anterior_side_of UBERON:0002367 ! prostate gland +relationship: in_anterior_side_of UBERON:0002367 ! prostate gland + +[Term] +id: UBERON:0035529 +name: left common iliac artery +is_a: UBERON:0001191 ! common iliac artery +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0001191 ! common iliac artery +intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: in_left_side_of UBERON:0000468 ! multicellular organism + [Term] id: UBERON:0035539 name: esophageal artery namespace: uberon def: "Any of several arteries that arise from the aorta and supply blood to the esophagus." [ncithesaurus:Esophageal_Artery] +subset: human_reference_atlas synonym: "aortic esophageal artery" EXACT [FMA:4149] synonym: "oesophageal artery" EXACT [FMA:4149] xref: FMA:4149 @@ -302599,7 +421824,17 @@ is_a: UBERON:0004573 {source="FMA"} ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: supplies UBERON:0001043 ! esophagus relationship: branching_part_of UBERON:0001515 {source="FMA"} ! thoracic aorta +relationship: connected_to UBERON:0002345 ! descending thoracic aorta relationship: supplies UBERON:0001043 ! esophagus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0035545 +name: deep lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0035551 ! deep vasculature +relationship: part_of UBERON:0035551 ! deep vasculature [Term] id: UBERON:0035546 @@ -302614,11 +421849,22 @@ intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0001768 ! uvea relationship: drains UBERON:0001768 ! uvea +[Term] +id: UBERON:0035548 +name: colic artery +namespace: uberon +xref: SCTID:77852007 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001155 ! colon +relationship: supplies UBERON:0001155 ! colon + [Term] id: UBERON:0035549 name: vasculature of integument namespace: uberon def: "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." [http://orcid.org/0000-0002-6601-2165] +subset: human_reference_atlas synonym: "dermis vasculature" NARROW [] synonym: "hypodermis vasculature" NARROW [] synonym: "skin vasculature" RELATED [] @@ -302632,6 +421878,7 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: located_in UBERON:0002199 ! integument relationship: capable_of_part_of GO:0001659 ! temperature homeostasis relationship: located_in UBERON:0002199 ! integument +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035550 @@ -302729,6 +421976,28 @@ xref: XAO:0004093 is_a: UBERON:0009955 ! neurogenic placode relationship: part_of UBERON:0003070 ! trigeminal placode complex +[Term] +id: UBERON:0035606 +name: cartilage of external acoustic meatus +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0034944 ! zone of organ +intersection_of: UBERON:0034944 ! zone of organ +intersection_of: part_of UBERON:0001352 ! external acoustic meatus +intersection_of: part_of UBERON:0001867 ! cartilage of external ear +relationship: part_of UBERON:0001352 ! external acoustic meatus +relationship: part_of UBERON:0001867 ! cartilage of external ear + +[Term] +id: UBERON:0035608 +name: dura mater lymph vessel +is_a: UBERON:0001473 ! lymphatic vessel +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: located_in UBERON:0002363 ! dura mater +relationship: located_in UBERON:0002363 ! dura mater +relationship: part_of UBERON:0010743 ! meningeal cluster + [Term] id: UBERON:0035612 name: nasal turbinal @@ -302775,7 +422044,6 @@ xref: NCIT:C32574 xref: SCTID:120612006 xref: UMLS:C0229243 xref: Wikipedia:Accessory_visual_structures -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0004088 ! orbital region @@ -302784,8 +422052,9 @@ id: UBERON:0035642 name: laryngeal nerve namespace: uberon def: "Any nerve that innervates the larynx." [UBERON:cjm] -xref: MESH:A08.800.050.050.925.450 +xref: MESH:D007823 xref: SCTID:307013006 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: innervates UBERON:0001737 ! larynx @@ -302799,7 +422068,30 @@ def: "Any nerve that innervates the pinna." [UBERON:cjm] synonym: "auricular nerve" EXACT [MA:0001232] xref: EMAPA:36513 xref: MA:0001232 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0011779 ! nerve of head region +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0001757 ! pinna +relationship: branching_part_of UBERON:0001647 ! facial nerve +relationship: innervates UBERON:0001757 ! pinna + +[Term] +id: UBERON:0035649 +name: nerve of penis +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0000989 ! penis +relationship: innervates UBERON:0000989 ! penis + +[Term] +id: UBERON:0035650 +name: nerve of clitoris +is_a: CARO:0001001 ! neuron projection bundle +is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0002411 ! clitoris +relationship: innervates UBERON:0002411 ! clitoris [Term] id: UBERON:0035651 @@ -302809,6 +422101,8 @@ xref: Wikipedia:Glans is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005156 ! reproductive structure +union_of: UBERON:0001299 ! glans penis +union_of: UBERON:0006653 ! glans clitoris relationship: develops_from UBERON:0013238 ! future glans relationship: part_of UBERON:0003133 ! reproductive organ @@ -302820,8 +422114,21 @@ def: "Any nerve that innervates the fibularis. Includes the common fibular nerve subset: grouping_class synonym: "peroneal nerve" EXACT [] xref: EMAPA:36511 -xref: MESH:A08.800.800.720.450.760.640 +xref: MESH:D010543 +is_a: CARO:0001001 ! neuron projection bundle is_a: UBERON:0001021 ! nerve +intersection_of: UBERON:0001021 ! nerve +intersection_of: innervates UBERON:0009132 ! peroneus +relationship: innervates UBERON:0009132 ! peroneus + +[Term] +id: UBERON:0035662 +name: parotid vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001831 ! parotid gland +relationship: drains UBERON:0001831 ! parotid gland +relationship: tributary_of UBERON:0001653 ! facial vein [Term] id: UBERON:0035763 @@ -302841,6 +422148,28 @@ relationship: luminal_space_of UBERON:0004151 ! cardiac chamber relationship: part_of UBERON:0004151 ! cardiac chamber relationship: surrounded_by UBERON:0002165 {source="FMA"} ! endocardium +[Term] +id: UBERON:0035764 +name: pulmonary lymph node +is_a: UBERON:0000029 ! lymph node +intersection_of: UBERON:0000029 ! lymph node +intersection_of: part_of UBERON:0008886 ! pulmonary vascular system +relationship: part_of UBERON:0008886 ! pulmonary vascular system + +[Term] +id: UBERON:0035767 +name: intrapulmonary bronchus +namespace: uberon +subset: human_reference_atlas +xref: FMA:223208 +xref: NCIT:C12930 +xref: UMLS:C1512970 +is_a: UBERON:0002185 ! bronchus +intersection_of: UBERON:0002185 ! bronchus +intersection_of: part_of UBERON:0002048 ! lung +relationship: part_of UBERON:0002048 ! lung +property_value: RO:0002175 NCBITaxon:9606 + [Term] id: UBERON:0035783 name: ganglion of ciliary nerve @@ -302857,7 +422186,6 @@ def: "The primordial mouth region of the developing head." [MP:0003119] synonym: "primitive mouth" EXACT [FMA:293105] synonym: "primordial mouth" EXACT [] xref: FMA:293105 -is_a: BFO:0000040 ! material entity is_a: CARO:0000000 ! anatomical entity is_a: UBERON:0013522 ! subdivision of tube relationship: has_part UBERON:0000925 ! endoderm @@ -302869,6 +422197,7 @@ id: UBERON:0035805 name: muscle layer of sigmoid colon namespace: uberon def: "A muscle layer that is part of the sigmoid colon" [https://github.com/obophenotype/uberon/issues/1162] +def: "A muscle layer that is part of the sigmoid colon." [https://github.com/obophenotype/uberon/issues/1162] synonym: "muscularis externa of sigmoid colon" EXACT [FMA:15028] synonym: "muscularis propria of sigmoid colon" EXACT [] synonym: "sigmoid colon muscularis propria" EXACT [] @@ -302966,6 +422295,38 @@ relationship: has_part UBERON:0001179 ! peritoneal cavity relationship: has_part UBERON:0002358 ! peritoneum relationship: located_in UBERON:0003684 ! abdominal cavity +[Term] +id: UBERON:0035825 +name: left adrenal gland cortex +is_a: UBERON:0001235 ! adrenal cortex +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0001234 ! left adrenal gland +relationship: part_of UBERON:0001234 ! left adrenal gland + +[Term] +id: UBERON:0035826 +name: left adrenal gland medulla +is_a: UBERON:0001236 ! adrenal medulla +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0001234 ! left adrenal gland +relationship: part_of UBERON:0001234 ! left adrenal gland + +[Term] +id: UBERON:0035827 +name: right adrenal gland cortex +is_a: UBERON:0001235 ! adrenal cortex +intersection_of: UBERON:0001851 ! cortex +intersection_of: part_of UBERON:0001233 ! right adrenal gland +relationship: part_of UBERON:0001233 ! right adrenal gland + +[Term] +id: UBERON:0035828 +name: right adrenal gland medulla +is_a: UBERON:0001236 ! adrenal medulla +intersection_of: UBERON:0000958 ! medulla of organ +intersection_of: part_of UBERON:0001233 ! right adrenal gland +relationship: part_of UBERON:0001233 ! right adrenal gland + [Term] id: UBERON:0035849 name: orbital margin @@ -302980,6 +422341,36 @@ is_a: UBERON:0005913 ! zone of bone organ is_a: UBERON:0010313 ! neural crest-derived structure relationship: part_of UBERON:0001697 ! orbit of skull +[Term] +id: UBERON:0035881 +name: ethmoidomaxillary suture +is_a: UBERON:0003685 ! cranial suture +intersection_of: UBERON:0003685 ! cranial suture +intersection_of: connects UBERON:0001679 ! ethmoid bone +intersection_of: connects UBERON:0002397 ! maxilla +relationship: connects UBERON:0001679 ! ethmoid bone +relationship: connects UBERON:0002397 ! maxilla + +[Term] +id: UBERON:0035884 +name: maxillary-premaxillary suture +is_a: UBERON:0003685 ! cranial suture +is_a: UBERON:2002260 ! premaxillary-maxillary joint +intersection_of: UBERON:0003685 ! cranial suture +intersection_of: connects UBERON:0002244 ! premaxilla +intersection_of: connects UBERON:0002397 ! maxilla + +[Term] +id: UBERON:0035956 +name: epididymal lumen +is_a: BFO:0000141 ! immaterial entity +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: luminal_space_of UBERON:0001301 ! epididymis +relationship: contains UBERON:0006530 ! seminal fluid +relationship: luminal_space_of UBERON:0001301 ! epididymis + [Term] id: UBERON:0035959 name: orbital pillar @@ -302997,7 +422388,6 @@ synonym: "vascular wall" RELATED [BTO:0004378] xref: BTO:0004378 xref: EMAPA:37987 {source="MA:th"} xref: FMA:67473 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -303005,6 +422395,21 @@ intersection_of: part_of UBERON:0001981 ! blood vessel relationship: composed_primarily_of UBERON:0004797 ! blood vessel layer relationship: part_of UBERON:0001981 ! blood vessel +[Term] +id: UBERON:0036072 +name: respiratory primordium epithelium +namespace: uberon +xref: EHDAA2:0004070 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009854 ! digestive tract diverticulum +is_a: UBERON:0015833 ! foregut epithelium +intersection_of: UBERON:0007499 ! epithelial sac +intersection_of: part_of UBERON:0008947 ! respiratory primordium +relationship: develops_from UBERON:0007690 {source="EHDAA2"} ! early pharyngeal endoderm +relationship: part_of UBERON:0008947 ! respiratory primordium + [Term] id: UBERON:0036073 name: respiratory primordium mesenchyme @@ -303018,11 +422423,20 @@ intersection_of: part_of UBERON:0008947 ! respiratory primordium relationship: develops_from UBERON:0004873 {source="EHDAA2"} ! splanchnopleure relationship: part_of UBERON:0008947 ! respiratory primordium +[Term] +id: UBERON:0036074 +name: vein of vestibular aqueduct +is_a: UBERON:0001638 ! vein +relationship: tributary_of UBERON:0001641 ! transverse sinus +relationship: tributary_of UBERON:0005475 ! sigmoid sinus +relationship: tributary_of UBERON:0007160 ! inferior petrosal sinus + [Term] id: UBERON:0036146 name: cardiopharyngeal field namespace: uberon def: "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." [BGEE:ann, http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1] +def: "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." [http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1, https://orcid.org/0000-0003-3308-6245] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -303038,6 +422452,14 @@ synonym: "follicle" BROAD [] synonym: "skin follicle" EXACT [] is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000063 ! organ subunit +intersection_of: has_potential_to_develop_into UBERON:0000021 ! cutaneous appendage +intersection_of: overlaps UBERON:0001003 ! skin epidermis +intersection_of: overlaps UBERON:0002067 ! dermis +intersection_of: part_of UBERON:0000014 ! zone of skin +relationship: has_potential_to_develop_into UBERON:0000021 ! cutaneous appendage +relationship: overlaps UBERON:0001003 ! skin epidermis +relationship: overlaps UBERON:0002067 ! dermis relationship: part_of UBERON:0000014 ! zone of skin [Term] @@ -303058,7 +422480,8 @@ def: "An anatomical junction that is between the sigmoid colon and rectum." [htt synonym: "rectosigmoid region" RELATED [NCIT:C54188] xref: http://www.snomedbrowser.com/Codes/Details/245429006 xref: NCIT:C54188 -is_a: UBERON:1100000 ! digestive tract junction +xref: SCTID:245429006 +is_a: UBERON:8410024 ! intestinal junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: connects UBERON:0001052 ! rectum intersection_of: connects UBERON:0001159 ! sigmoid colon @@ -303073,7 +422496,6 @@ def: "Material anatomical entity that forms the outermost boundary of an anatomi xref: AAO:0010270 xref: AEO:0000154 xref: ZFA:0005594 -is_a: BFO:0000040 ! material entity is_a: UBERON:0000465 ! material anatomical entity relationship: bounding_layer_of UBERON:0000061 ! anatomical structure relationship: part_of UBERON:0000061 ! anatomical structure @@ -303085,7 +422507,6 @@ namespace: uberon def: "A bodily fluid that is located in the coelom." [https://github.com/obophenotype/uberon/issues/1326, PMID:10874572] def: "A bodily fluid that is located in the coelom." [http://www.ncbi.nlm.nih.gov/pubmed/10874572, https://github.com/obophenotype/uberon/issues/1326] xref: BTO:0001708 -is_a: BFO:0000040 ! material entity is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: located_in UBERON:0011997 ! coelom @@ -303097,7 +422518,7 @@ id: UBERON:0036224 name: corticobulbar and corticospinal tracts namespace: uberon def: "The corticobulbar and corticospinal tracts combined." [https://github.com/obophenotype/uberon/issues/553] -synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320, MP:0002878] +synonym: "pyramidal tract" BROAD INCONSISTENT [BIRNLEX:1464, MP:0002878, neuronames:1320] xref: Wikipedia:Pyramidal_tracts is_a: UBERON:0001018 ! axon tract relationship: part_of UBERON:0002316 {source="NIFSTD"} ! white matter @@ -303128,6 +422549,14 @@ property_value: RO:0002175 NCBITaxon:7746 property_value: RO:0002175 NCBITaxon:7878 property_value: RO:0002175 NCBITaxon:8292 +[Term] +id: UBERON:0036243 +name: vaginal fluid +is_a: UBERON:0006314 ! bodily fluid +intersection_of: UBERON:0006314 ! bodily fluid +intersection_of: located_in UBERON:0000996 ! vagina +relationship: located_in UBERON:0000996 ! vagina + [Term] id: UBERON:0036244 name: secretion of serous membrane @@ -303136,13 +422565,30 @@ def: "A transudate found in the serous sac." [FMA:20932] synonym: "serous fluid" BROAD [FMA:20932] synonym: "serous sac fluid" EXACT [] xref: FMA:20932 -is_a: BFO:0000040 ! material entity is_a: UBERON:0007779 ! transudate intersection_of: UBERON:0007779 ! transudate intersection_of: filtered_through UBERON:0000042 ! serous membrane relationship: filtered_through UBERON:0000042 ! serous membrane relationship: located_in UBERON:0005906 ! serous sac +[Term] +id: UBERON:0036245 +name: parenchyma of mammary gland +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0001911 ! mammary gland +relationship: part_of UBERON:0001911 ! mammary gland + +[Term] +id: UBERON:0036248 +name: joint of auditory ossicle +is_a: UBERON:0002217 ! synovial joint +intersection_of: UBERON:0002217 ! synovial joint +intersection_of: connects UBERON:0035130 ! auditory ossicle endochondral element +relationship: connects UBERON:0035130 ! auditory ossicle endochondral element +relationship: part_of UBERON:0000033 ! head + [Term] id: UBERON:0036253 name: orifice of skull @@ -303163,6 +422609,22 @@ def: "The system that is responsible for sensing the internal state of the body. xref: Wikipedia:Interoception is_a: UBERON:0001032 ! sensory system +[Term] +id: UBERON:0036262 +name: uterine ligament +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000211 ! ligament +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000211 ! ligament +intersection_of: part_of UBERON:0000002 ! uterine cervix +relationship: part_of UBERON:0000002 ! uterine cervix + +[Term] +id: UBERON:0036263 +name: supraglottic part of larynx +is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract +relationship: part_of UBERON:0001737 ! larynx + [Term] id: UBERON:0036264 name: zygomaticotemporal nerve @@ -303179,16 +422641,33 @@ xref: Wikipedia:Zygomaticotemporal_nerve is_a: UBERON:0011779 ! nerve of head region relationship: branching_part_of UBERON:0000377 ! maxillary nerve +[Term] +id: UBERON:0036267 +name: vulval vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0000997 ! mammalian vulva +relationship: drains UBERON:0000997 ! mammalian vulva + [Term] id: UBERON:0036268 name: pelvic vein namespace: uberon xref: http://www.snomedbrowser.com/Codes/Details/13152008 +xref: SCTID:13152008 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: drains UBERON:0002355 ! pelvic region of trunk relationship: drains UBERON:0002355 ! pelvic region of trunk +[Term] +id: UBERON:0036269 +name: penis blood vessel +is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: connected_to UBERON:0000989 ! penis +relationship: connected_to UBERON:0000989 ! penis + [Term] id: UBERON:0036285 name: wall of left ventricle @@ -303287,10 +422766,22 @@ def: "The upper tract of the renal system. The renal pelvis is the large cavity synonym: "renal pelvis and ureter" EXACT [] synonym: "renal pelvis plus ureter" EXACT [] xref: NCIT:C54419 -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0000477 ! anatomical cluster relationship: part_of UBERON:0011143 {source="NCIT"} ! upper urinary tract +[Term] +id: UBERON:0036301 +name: vasculature of spleen +namespace: uberon +xref: FMA:225251 +xref: SCTID:297287005 +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0002201 ! vasculature of trunk +is_a: UBERON:0006876 {source="FMA"} ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: part_of UBERON:0002106 ! spleen +relationship: part_of UBERON:0002106 ! spleen + [Term] id: UBERON:0036302 name: vasculature of central nervous system plus retina @@ -303310,6 +422801,40 @@ intersection_of: UBERON:0002049 ! vasculature intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system +[Term] +id: UBERON:0036304 +name: anatomical border +is_a: UBERON:0000061 ! anatomical structure + +[Term] +id: UBERON:0036328 +name: wall of coronary artery +is_a: UBERON:0000415 ! artery wall +is_a: UBERON:0037144 ! wall of heart +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001621 ! coronary artery +relationship: part_of UBERON:0001621 ! coronary artery + +[Term] +id: UBERON:0036337 +name: wall of appendix +is_a: UBERON:0001169 ! wall of large intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:0036343 +name: wall of gallbladder +namespace: uberon +synonym: "gallbladder wall" EXACT [FMA:14657] +xref: FMA:14657 +is_a: UBERON:0003697 ! abdominal wall +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002110 ! gall bladder +relationship: part_of UBERON:0002110 {source="FMA"} ! gall bladder + [Term] id: UBERON:0036351 name: wall of brachiocephalic artery @@ -303321,6 +422846,17 @@ intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0001529 ! brachiocephalic artery relationship: part_of UBERON:0001529 {source="FMA"} ! brachiocephalic artery +[Term] +id: UBERON:0036352 +name: wall of subclavian artery +namespace: uberon +synonym: "subclavian arterial wall" EXACT [FMA:15090] +xref: FMA:15090 +is_a: UBERON:0000415 {source="FMA"} ! artery wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001533 ! subclavian artery +relationship: part_of UBERON:0001533 {source="FMA"} ! subclavian artery + [Term] id: UBERON:0036362 name: wall of anal canal @@ -303334,10 +422870,27 @@ intersection_of: part_of UBERON:0000159 ! anal canal intersection_of: part_of UBERON:0001007 ! digestive system relationship: part_of UBERON:0000159 {source="FMA"} ! anal canal +[Term] +id: UBERON:0036375 +name: wall of right ureter +is_a: UBERON:0009916 ! wall of ureter +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001222 ! right ureter +relationship: part_of UBERON:0001222 ! right ureter + +[Term] +id: UBERON:0036376 +name: wall of left ureter +is_a: UBERON:0009916 ! wall of ureter +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001223 ! left ureter +relationship: part_of UBERON:0001223 ! left ureter + [Term] id: UBERON:0036422 name: wall of pulmonary artery namespace: uberon +subset: human_reference_atlas synonym: "pulmonary arterial wall" EXACT [FMA:18211] xref: FMA:18211 is_a: UBERON:0000415 {source="FMA"} ! artery wall @@ -303345,6 +422898,22 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0002012 ! pulmonary artery relationship: part_of UBERON:0002012 {source="FMA"} ! pulmonary artery +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0036441 +name: wall of uterine tube +namespace: uberon +synonym: "uterine tube wall" EXACT [FMA:18303] +synonym: "wall of fallopian tube" EXACT [FMA:18303] +synonym: "wall of oviduct" EXACT [FMA:18303] +xref: FMA:18303 +is_a: UBERON:0000060 {source="FMA"} ! anatomical wall +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0003889 ! fallopian tube +relationship: part_of UBERON:0003889 {source="FMA"} ! fallopian tube [Term] id: UBERON:0036521 @@ -303358,6 +422927,16 @@ intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000057 ! urethra relationship: part_of UBERON:0000057 {source="FMA"} ! urethra +[Term] +id: UBERON:0036523 +name: wall of vagina +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005156 ! reproductive structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0000996 ! vagina +relationship: part_of UBERON:0000996 ! vagina + [Term] id: UBERON:0036553 name: wall of synovial tendon sheath @@ -303369,6 +422948,52 @@ intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0000304 ! tendon sheath relationship: part_of UBERON:0000304 {source="FMA"} ! tendon sheath +[Term] +id: UBERON:0036654 +name: wall of lateral ventricle +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0036661 ! wall of ventricular system of brain +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002285 ! telencephalic ventricle +relationship: part_of UBERON:0002285 ! telencephalic ventricle + +[Term] +id: UBERON:0036656 +name: wall of third ventricle +is_a: UBERON:0036661 ! wall of ventricular system of brain +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002286 ! third ventricle +relationship: part_of UBERON:0002286 ! third ventricle + +[Term] +id: UBERON:0036657 +name: wall of fourth ventricle +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0036661 ! wall of ventricular system of brain +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002422 ! fourth ventricle +relationship: part_of UBERON:0002422 ! fourth ventricle + +[Term] +id: UBERON:0036658 +name: wall of central canal of spinal cord +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005358 ! ventricle of nervous system +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002291 ! central canal of spinal cord +relationship: part_of UBERON:0002291 ! central canal of spinal cord + +[Term] +id: UBERON:0036661 +name: wall of ventricular system of brain +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0005358 ! ventricle of nervous system +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0005282 ! ventricular system of brain +relationship: part_of UBERON:0005282 ! ventricular system of brain + [Term] id: UBERON:0036925 name: wall of eyeball @@ -303381,6 +423006,24 @@ intersection_of: UBERON:0000060 ! anatomical wall intersection_of: part_of UBERON:0010230 ! eyeball of camera-type eye relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye +[Term] +id: UBERON:0036990 +name: wall of pharyngotympanic tube +is_a: UBERON:0000060 ! anatomical wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0002393 ! pharyngotympanic tube +relationship: part_of UBERON:0002393 ! pharyngotympanic tube + +[Term] +id: UBERON:0037089 +name: wall of orbit +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0000075 ! subdivision of skeletal system +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001697 ! orbit of skull +relationship: part_of UBERON:0001697 ! orbit of skull + [Term] id: UBERON:0037094 name: wall of common carotid artery @@ -303401,6 +423044,7 @@ def: "Wall of organ which has as its parts the endocardium, myocardium , epicard def: "wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." [FMA:7274] synonym: "cardiac wall" EXACT [FMA:7274] xref: FMA:7274 +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000060 {source="FMA"} ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -303409,6 +423053,132 @@ relationship: attaches_to UBERON:0002406 {source="FMA"} ! pericardial sac relationship: attaches_to UBERON:0004292 {source="FMA"} ! cardiac skeleton relationship: part_of UBERON:0000948 {source="FMA"} ! heart +[Term] +id: UBERON:0037191 +name: wall of membranous labyrinth +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001849 ! membranous labyrinth +relationship: part_of UBERON:0001849 ! membranous labyrinth + +[Term] +id: UBERON:0037237 +name: wall of lacrimal duct +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001850 ! lacrimal drainage system +relationship: part_of UBERON:0001850 ! lacrimal drainage system + +[Term] +id: UBERON:0037447 +name: wall of male urethra +is_a: UBERON:0036521 ! wall of urethra +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001333 ! male urethra +relationship: part_of UBERON:0001333 ! male urethra + +[Term] +id: UBERON:0037455 +name: wall of female urethra +is_a: UBERON:0036521 ! wall of urethra +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: part_of UBERON:0001334 ! female urethra +relationship: part_of UBERON:0001334 ! female urethra + +[Term] +id: UBERON:0037458 +name: hair of neck +is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0000974 ! neck +relationship: part_of UBERON:0000974 ! neck + +[Term] +id: UBERON:0037459 +name: hair of limb +is_a: UBERON:0001037 ! strand of hair +intersection_of: UBERON:0001037 ! strand of hair +intersection_of: part_of UBERON:0002101 ! limb +relationship: part_of UBERON:0002101 ! limb + +[Term] +id: UBERON:0039175 +name: subarachnoid space of brain +namespace: uberon +xref: FMA:322073 +is_a: UBERON:0000315 {source="FMA"} ! subarachnoid space + +[Term] +id: UBERON:0039222 +name: cystic artery +namespace: uberon +def: "An artery that supplies oxygenated blood to the cystic duct." [http://orcid.org/0000-0002-6601-2165, https://en.wikipedia.org/wiki/Cystic_artery] +synonym: "cholecystic artery" EXACT [FMA:14835] +xref: FMA:14835 +is_a: UBERON:0001637 ! artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001152 ! cystic duct +relationship: part_of UBERON:0015482 {source="FMA", source="Wikipedia"} ! right hepatic artery +relationship: supplies UBERON:0001152 ! cystic duct + +[Term] +id: UBERON:0039228 +name: sigmoid vein +namespace: uberon +xref: FMA:15395 +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0001159 ! sigmoid colon +relationship: drains UBERON:0001159 ! sigmoid colon +relationship: tributary_of UBERON:0001215 {source="FMA"} ! inferior mesenteric vein + +[Term] +id: UBERON:0039261 +name: pancreatic artery +namespace: uberon +xref: FMA:70471 +is_a: UBERON:0004573 ! systemic artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0001264 ! pancreas +relationship: branching_part_of UBERON:0001194 ! splenic artery +relationship: supplies UBERON:0001264 ! pancreas + +[Term] +id: UBERON:0039856 +name: right ovarian vein +namespace: uberon +def: "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." [FMA:14342] +xref: FMA:14342 +is_a: UBERON:0001145 {source="FMA"} ! ovarian vein +intersection_of: UBERON:0001145 ! ovarian vein +intersection_of: drains UBERON:0002118 ! right ovary +relationship: drains UBERON:0002118 ! right ovary +relationship: tributary_of UBERON:0001072 {source="FMA"} ! posterior vena cava + +[Term] +id: UBERON:0039857 +name: left ovarian vein +namespace: uberon +def: "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." [FMA:14347] +xref: FMA:14347 +is_a: UBERON:0001145 {source="FMA"} ! ovarian vein +intersection_of: UBERON:0001145 ! ovarian vein +intersection_of: drains UBERON:0002119 ! left ovary +relationship: drains UBERON:0002119 ! left ovary + +[Term] +id: UBERON:1000004 +name: collection of hair on external ear +is_a: UBERON:0014382 ! collection of hairs on head or neck +intersection_of: UBERON:0010164 ! collection of hairs +intersection_of: part_of UBERON:0001691 ! external ear +relationship: composed_primarily_of UBERON:0022279 ! strand of hair on external ear +relationship: part_of UBERON:0001691 ! external ear + [Term] id: UBERON:1000021 name: skin of face @@ -303430,6 +423200,7 @@ intersection_of: UBERON:0000014 ! zone of skin intersection_of: part_of UBERON:0001456 ! face relationship: dc-contributor https://github.com/cmungall relationship: dc-contributor https://github.com/seger +relationship: dc-contributor https://orcid.org/0000-0002-9611-1279 relationship: part_of UBERON:0001456 ! face created_by: eriks creation_date: 2012-02-05T05:23:01Z @@ -303439,6 +423210,7 @@ id: UBERON:1000023 name: spleen pulp namespace: uberon def: "The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages." [ncithesaurus:Splenic_Pulp] +subset: human_reference_atlas synonym: "Malpighian corpuscles" EXACT [FMA:15845] synonym: "pulp of spleen" EXACT [] synonym: "splenic pulp" EXACT [] @@ -303451,6 +423223,7 @@ xref: UMLS:C0229691 {source="ncithesaurus:Splenic_Pulp"} is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: part_of UBERON:1000024 {source="FMA"} ! parenchyma of spleen +property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:1000024 @@ -303461,6 +423234,8 @@ synonym: "splenic parenchyma" EXACT [FMA:16029] xref: FMA:16029 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: part_of UBERON:0002106 ! spleen relationship: part_of UBERON:0002106 ! spleen [Term] @@ -303472,7 +423247,7 @@ is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: connects UBERON:0004921 ! subdivision of digestive tract relationship: connects UBERON:0004921 ! subdivision of digestive tract -property_value: http://purl.org/dc/elements/1.1/creator http://orcid.org/0000-0002-7073-9172 +relationship: dc-contributor https://orcid.org/0000-0002-7073-9172 creation_date: 2021-02-05T11:19:31Z [Term] @@ -303484,8 +423259,7 @@ synonym: "opercular apparatus" EXACT [TAO:0000555] synonym: "operculum" RELATED [TAO:0000555] xref: ZFA:0000555 is_a: UBERON:0003102 ! surface structure -property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -created_by: teleost_anatomy_curators +property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/tao.owl"} [Term] id: UBERON:2001053 @@ -303502,6 +423276,11 @@ relationship: develops_from UBERON:0003120 {gci_relation="part_of", gci_filler=" relationship: develops_from UBERON:0004363 ! pharyngeal arch artery relationship: part_of UBERON:0001530 {source="EHDAA2"} ! common carotid artery plus branches +[Term] +id: UBERON:2001073 +name: axial vasculature +is_a: UBERON:0002049 ! vasculature + [Term] id: UBERON:2001431 name: primitive olfactory epithelium @@ -303510,8 +423289,7 @@ xref: ZFA:0001431 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium relationship: part_of UBERON:0003050 ! olfactory placode -property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -created_by: teleost_anatomy_curators +property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/tao.owl"} [Term] id: UBERON:2001457 @@ -303525,7 +423303,7 @@ intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0002090 ! postcranial axial skeleton relationship: part_of UBERON:0002090 ! postcranial axial skeleton property_value: provenance_notes "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/tao.owl"} created_by: teleost_anatomy_curators [Term] @@ -303534,8 +423312,27 @@ name: premaxillary tooth namespace: uberon def: "Tooth that is attached to the premaxilla." [TAO:wd] is_a: UBERON:0003267 ! tooth of upper jaw -property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -created_by: teleost_anatomy_curators +intersection_of: UBERON:0001091 ! calcareous tooth +intersection_of: attaches_to UBERON:0002244 ! premaxilla +relationship: attaches_to UBERON:0002244 ! premaxilla +property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/tao.owl"} + +[Term] +id: UBERON:2001950 +name: inter-premaxillary joint +is_a: UBERON:0000982 ! skeletal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002244 ! premaxilla +relationship: connects UBERON:0002244 ! premaxilla + +[Term] +id: UBERON:2002260 +name: premaxillary-maxillary joint +is_a: UBERON:2001950 ! inter-premaxillary joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: connects UBERON:0002244 ! premaxilla +intersection_of: connects UBERON:0002397 ! maxilla +relationship: connects UBERON:0002397 ! maxilla [Term] id: UBERON:2005260 @@ -303562,8 +423359,7 @@ namespace: uberon def: "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." [ZFIN:curator] xref: ZFA:0007013 is_a: UBERON:0005497 ! non-neural ectoderm -property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -created_by: teleost_anatomy_curators +property_value: UBPROP:0000004 "This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/tao.owl"} [Term] id: UBERON:3000961 @@ -303577,7 +423373,7 @@ intersection_of: UBERON:0003102 ! surface structure intersection_of: part_of UBERON:0002199 ! integument relationship: part_of UBERON:0002199 ! integument property_value: provenance_notes "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} created_by: amphibian_anatomy_curators [Term] @@ -303591,7 +423387,7 @@ intersection_of: UBERON:3000961 ! external integument structure intersection_of: part_of UBERON:0000033 ! head relationship: part_of UBERON:0000033 ! head property_value: provenance_notes "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} created_by: amphibian_anatomy_curators [Term] @@ -303605,7 +423401,7 @@ intersection_of: UBERON:3000961 ! external integument structure intersection_of: part_of UBERON:0002100 ! trunk relationship: part_of UBERON:0002100 ! trunk property_value: provenance_notes "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} created_by: amphibian_anatomy_curators [Term] @@ -303619,9 +423415,17 @@ intersection_of: UBERON:3000961 ! external integument structure intersection_of: part_of UBERON:0002101 ! limb relationship: part_of UBERON:0002101 ! limb property_value: provenance_notes "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string -property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} created_by: amphibian_anatomy_curators +[Term] +id: UBERON:3000982 +name: tail external integument structure +is_a: UBERON:3000961 ! external integument structure +intersection_of: UBERON:3000961 ! external integument structure +intersection_of: part_of UBERON:0007812 ! post-anal tail +relationship: part_of UBERON:0007812 ! post-anal tail + [Term] id: UBERON:3010200 name: vasculature of respiratory integument @@ -303634,8 +423438,20 @@ intersection_of: part_of UBERON:0001004 ! respiratory system intersection_of: part_of UBERON:0002199 ! integument relationship: part_of UBERON:0002199 ! integument property_value: editor_note "Modified from the original AAO source" xsd:string +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} created_by: amphibian_anatomy_curators +[Term] +id: UBERON:3011048 +name: genital system +namespace: uberon +def: "Anatomical system that has as its parts the organs concerned with reproduction, especially the external genital organs." [https://www.merriam-webster.com/dictionary/genitalia, XAO:0000142] +synonym: "genitalia" BROAD [] +synonym: "reproductive system" BROAD [] +is_a: UBERON:0000467 ! anatomical system +relationship: part_of UBERON:0004122 ! genitourinary system +property_value: UBPROP:0000004 "This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon" xsd:string {source="http://purl.obolibrary.org/obo/aao.owl"} + [Term] id: UBERON:4000013 name: mineralized skeletal tissue @@ -303645,6 +423461,26 @@ synonym: "mineralized tissue" BROAD [VSAO:0000013] xref: VSAO:0000013 xref: XAO:0004039 is_a: UBERON:0004755 ! skeletal tissue +intersection_of: UBERON:0004755 ! skeletal tissue +intersection_of: has_quality PATO:0002444 ! mineralized +relationship: has_quality PATO:0002444 ! mineralized + +[Term] +id: UBERON:4000020 +name: mineralized extracellular matrix +is_a: GO:0031012 ! extracellular matrix +is_a: UBERON:0000479 ! tissue + +[Term] +id: UBERON:4000115 +name: mineralized bone tissue +is_a: UBERON:0002481 ! bone tissue +is_a: UBERON:4000013 ! mineralized skeletal tissue +intersection_of: UBERON:0002481 ! bone tissue +intersection_of: has_quality PATO:0002444 ! mineralized +relationship: develops_from UBERON:0008883 ! osteoid +relationship: has_part CHEBI:52255 ! hydroxylapatite +relationship: has_part UBERON:4000020 ! mineralized extracellular matrix [Term] id: UBERON:4100000 @@ -303652,8 +423488,20 @@ name: skeletal element projection namespace: uberon def: "Anatomical projection that is composed of bone or cartilage tissue." [PHENOSCAPE] is_a: UBERON:0004529 ! anatomical projection +intersection_of: UBERON:0004529 ! anatomical projection +intersection_of: part_of UBERON:0004765 ! skeletal element relationship: part_of UBERON:0004765 ! skeletal element +[Term] +id: UBERON:4200172 +name: neck of humerus +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005055 ! zone of long bone +is_a: UBERON:0018664 ! neck of bone element +intersection_of: UBERON:0001560 ! neck of organ +intersection_of: part_of UBERON:0000976 ! humerus +relationship: part_of UBERON:0004411 ! proximal epiphysis of humerus + [Term] id: UBERON:4200230 name: surface of bone @@ -303661,7 +423509,6 @@ namespace: uberon def: "An anatomical surface that is part of a bone" [] def: "An anatomical surface that is part of a bone." [PHENOSCAPE] synonym: "bone surface" EXACT [] -is_a: BFO:0000004 ! independent continuant is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: part_of UBERON:0001474 ! bone element @@ -303701,6 +423548,10 @@ synonym: "manual digit 1 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit I plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5002389 ! manual digit plus metapodial segment is_a: UBERON:5006048 ! digit 1 plus metapodial segment +intersection_of: UBERON:5006048 ! digit 1 plus metapodial segment +intersection_of: part_of UBERON:0002398 ! manus +relationship: has_part UBERON:0001463 ! manual digit 1 +relationship: has_skeleton UBERON:5101463 ! manual digit 1 digitopodial skeleton relationship: part_of UBERON:0002398 ! manus property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} @@ -303714,6 +423565,10 @@ synonym: "pedal digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPA synonym: "pedal digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5002544 ! digit plus metapodial segment +intersection_of: UBERON:5002544 ! digit plus metapodial segment +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_part UBERON:0001466 ! pedal digit +relationship: has_skeleton UBERON:5101466 ! pedal digit digitopodial skeleton relationship: part_of UBERON:0002387 ! pes property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} @@ -303727,6 +423582,10 @@ synonym: "manual digit ( phalanges plus metapodial) plus soft tissue" BROAD COMP synonym: "manual digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5002544 ! digit plus metapodial segment +intersection_of: UBERON:5002544 ! digit plus metapodial segment +intersection_of: part_of UBERON:0002102 ! forelimb +relationship: has_part UBERON:0002389 ! manual digit +relationship: has_skeleton UBERON:5102389 ! manual digit digitopodial skeleton relationship: part_of UBERON:0002102 ! forelimb property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} @@ -303739,7 +423598,12 @@ synonym: "digit" BROAD [http://orcid.org/0000-0002-6601-2165] synonym: "digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "digit ray" EXACT [http://orcid.org/0000-0002-6601-2165] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0000475 ! organism subdivision +intersection_of: UBERON:0000475 ! organism subdivision +intersection_of: has_skeleton UBERON:5102544 ! individual digit of digitopodial skeleton +relationship: has_part UBERON:0002544 ! digit +relationship: has_skeleton UBERON:5102544 ! individual digit of digitopodial skeleton relationship: part_of UBERON:0012140 ! digitopodium region property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} @@ -303800,6 +423664,10 @@ synonym: "manual digit 5 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit V plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5002389 ! manual digit plus metapodial segment is_a: UBERON:5006052 ! digit 5 plus metapodial segment +intersection_of: UBERON:5006052 ! digit 5 plus metapodial segment +intersection_of: part_of UBERON:0002398 ! manus +relationship: has_part UBERON:0003625 ! manual digit 5 +relationship: has_skeleton UBERON:5103625 ! manual digit 5 digitopodial skeleton relationship: part_of UBERON:0002398 ! manus property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} @@ -303815,6 +423683,10 @@ synonym: "pedal digit 1 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit I plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5001466 ! pedal digit plus metapodial segment is_a: UBERON:5006048 ! digit 1 plus metapodial segment +intersection_of: UBERON:5006048 ! digit 1 plus metapodial segment +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_part UBERON:0003631 ! pedal digit 1 +relationship: has_skeleton UBERON:5103631 ! pedal digit 1 digitopodial skeleton property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} [Term] @@ -303871,6 +423743,10 @@ synonym: "pedal digit 5 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit V plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5001466 ! pedal digit plus metapodial segment is_a: UBERON:5006052 ! digit 5 plus metapodial segment +intersection_of: UBERON:5006052 ! digit 5 plus metapodial segment +intersection_of: part_of UBERON:0002387 ! pes +relationship: has_part UBERON:0003635 ! pedal digit 5 +relationship: has_skeleton UBERON:5103635 ! pedal digit 5 digitopodial skeleton property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} [Term] @@ -303884,6 +423760,10 @@ synonym: "digit 1 digitopodial subdivision" EXACT [http://orcid.org/0000-0002-66 synonym: "digit 1 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "digit I plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5002544 ! digit plus metapodial segment +intersection_of: UBERON:5002544 ! digit plus metapodial segment +intersection_of: has_skeleton UBERON:5106048 ! digit 1 digitopodial skeleton +relationship: has_part UBERON:0006048 ! digit 1 +relationship: has_skeleton UBERON:5106048 ! digit 1 digitopodial skeleton property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} [Term] @@ -303936,6 +423816,10 @@ synonym: "digit 5 digitopodial subdivision" EXACT [http://orcid.org/0000-0002-66 synonym: "digit 5 ray" EXACT [http://orcid.org/0000-0002-6601-2165] synonym: "digit V plus metapodial segment" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5002544 ! digit plus metapodial segment +intersection_of: UBERON:5002544 ! digit plus metapodial segment +intersection_of: has_skeleton UBERON:5106052 ! digit 5 digitopodial skeleton +relationship: has_part UBERON:0006052 ! digit 5 +relationship: has_skeleton UBERON:5106052 ! digit 5 digitopodial skeleton property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element plus associated soft tissues. Instances of this class typically do not form a distinct unit." xsd:string {source="https://github.com/obophenotype/uberon/issues/458"} [Term] @@ -303948,7 +423832,10 @@ synonym: "manual digit 1 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165 synonym: "manual digit I digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5102389 ! manual digit digitopodial skeleton is_a: UBERON:5106048 ! digit 1 digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5001463 ! manual digit 1 plus metapodial segment relationship: part_of UBERON:5001463 ! manual digit 1 plus metapodial segment +relationship: skeleton_of UBERON:5001463 ! manual digit 1 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -303959,7 +423846,10 @@ def: "A subdivision of the skeleton of the autopod consisting of the phalanges o synonym: "pedal digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5001466 ! pedal digit plus metapodial segment relationship: part_of UBERON:5001466 ! pedal digit plus metapodial segment +relationship: skeleton_of UBERON:5001466 ! pedal digit plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -303970,7 +423860,10 @@ def: "A subdivision of the skeleton of the autopod consisting of the phalanges o synonym: "manual digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "manual digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5002389 ! manual digit plus metapodial segment relationship: part_of UBERON:5002389 ! manual digit plus metapodial segment +relationship: skeleton_of UBERON:5002389 ! manual digit plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -303980,10 +423873,14 @@ namespace: uberon def: "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." [http://orcid.org/0000-0002-6601-2165] synonym: "digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165] synonym: "digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] +is_a: CARO:0000003 ! connected anatomical structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010712 ! limb skeleton subdivision +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5002544 ! digit plus metapodial segment relationship: part_of UBERON:0012150 ! skeleton of digitopodium relationship: part_of UBERON:5002544 ! digit plus metapodial segment +relationship: skeleton_of UBERON:5002544 ! digit plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -304035,7 +423932,10 @@ synonym: "manual digit 5 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165 synonym: "manual digit V digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5102389 ! manual digit digitopodial skeleton is_a: UBERON:5106052 ! digit 5 digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5003625 ! manual digit 5 plus metapodial segment relationship: part_of UBERON:5003625 ! manual digit 5 plus metapodial segment +relationship: skeleton_of UBERON:5003625 ! manual digit 5 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -304048,7 +423948,10 @@ synonym: "pedal digit 1 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit I digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5101466 ! pedal digit digitopodial skeleton is_a: UBERON:5106048 ! digit 1 digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5003631 ! pedal digit 1 plus metapodial segment relationship: part_of UBERON:5003631 ! pedal digit 1 plus metapodial segment +relationship: skeleton_of UBERON:5003631 ! pedal digit 1 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -304100,7 +424003,10 @@ synonym: "pedal digit 5 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "pedal digit V digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5101466 ! pedal digit digitopodial skeleton is_a: UBERON:5106052 ! digit 5 digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5003635 ! pedal digit 5 plus metapodial segment relationship: part_of UBERON:5003635 ! pedal digit 5 plus metapodial segment +relationship: skeleton_of UBERON:5003635 ! pedal digit 5 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -304112,7 +424018,10 @@ synonym: "digit 1" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-660 synonym: "digit 1 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "digit I digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5006048 ! digit 1 plus metapodial segment relationship: part_of UBERON:5006048 ! digit 1 plus metapodial segment +relationship: skeleton_of UBERON:5006048 ! digit 1 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string [Term] @@ -304160,9 +424069,23 @@ synonym: "digit 5" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-660 synonym: "digit 5 skeleton" RELATED [http://orcid.org/0000-0002-6601-2165] synonym: "digit V digitopodial skeleton" EXACT COMPARATIVE_PREFERRED [https://github.com/obophenotype/uberon/issues/458] is_a: UBERON:5102544 ! individual digit of digitopodial skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: skeleton_of UBERON:5006052 ! digit 5 plus metapodial segment relationship: part_of UBERON:5006052 ! digit 5 plus metapodial segment +relationship: skeleton_of UBERON:5006052 ! digit 5 plus metapodial segment property_value: IAO:0000232 "this class represents a series of phalanges plus a metapodial element. In comparative anatomy terminology we would call this a 'digit', but the label 'digit' is sometimes used to exclude metapodials and to include soft tissue. This series of elements is hypothesized to be homologous to radials." xsd:string +[Term] +id: UBERON:6000002 +name: arthropod tagma +namespace: uberon +def: "One of the main divisions of the whole organism of arthropods formed from groups of segments." [doi:10.1016/B978-0-12-385026-3.00024-3] +comment: Strictly speaking the term "tagma" cam be used for any metameric organism, however we follow the common usage which is to restrict the term to arthropods. +xref: FBbt:00000002 +is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda +property_value: RO:0002161 NCBITaxon:7742 + [Term] id: UBERON:6000004 name: panarthropod head @@ -304173,6 +424096,61 @@ intersection_of: UBERON:0000033 ! head intersection_of: part_of NCBITaxon:88770 ! Panarthropoda relationship: part_of NCBITaxon:88770 ! Panarthropoda +[Term] +id: UBERON:6000137 +name: embryonic tagma +namespace: uberon +def: "Any tagma (UBERON:6000002) that is part of some embryo (UBERON:6000052)." [FBC:auto_generated_definition] +xref: FBbt:00000137 +is_a: UBERON:6000002 ! arthropod tagma +intersection_of: UBERON:6000002 ! arthropod tagma +intersection_of: part_of UBERON:0000922 ! embryo +relationship: part_of UBERON:0000922 ! embryo + +[Term] +id: UBERON:6003005 +name: insect adult tagma +namespace: uberon +def: "Any tagma (UBERON:6000002) that is part of some adult (UBERON:6003004)." [FBC:auto_generated_definition] +xref: FBbt:00003005 +is_a: UBERON:6000002 ! arthropod tagma +intersection_of: UBERON:6000002 ! arthropod tagma +intersection_of: part_of UBERON:0007023 ! adult organism +relationship: part_of UBERON:0007023 ! adult organism + +[Term] +id: UBERON:6003007 +name: insect adult head +namespace: uberon +def: "Head of the adult organism." [FBC:SPR] +xref: FBbt:00003007 +is_a: UBERON:6000004 ! panarthropod head +is_a: UBERON:6003005 ! insect adult tagma +intersection_of: UBERON:0000033 ! head +intersection_of: part_of NCBITaxon:50557 ! Insecta +intersection_of: part_of UBERON:0007023 ! adult organism +relationship: part_of NCBITaxon:50557 ! Insecta + +[Term] +id: UBERON:7500062 +name: tibial tuberosity +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005813 ! tubercle +is_a: UBERON:4100000 ! skeletal element projection +intersection_of: UBERON:0005813 ! tubercle +intersection_of: part_of UBERON:0008772 ! proximal epiphysis of tibia +relationship: part_of UBERON:0008772 ! proximal epiphysis of tibia + +[Term] +id: UBERON:7500094 +name: tubercle of calcaneus +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005813 ! tubercle +is_a: UBERON:4100000 ! skeletal element projection +intersection_of: UBERON:0005813 ! tubercle +intersection_of: part_of UBERON:0001450 ! calcaneus +relationship: part_of UBERON:0001450 ! calcaneus + [Term] id: UBERON:8000006 name: left side of back @@ -304182,8 +424160,8 @@ is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism +relationship: dc-contributor https://orcid.org/0000-0001-5208-3432 relationship: in_left_side_of UBERON:0000468 ! multicellular organism -created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: UBERON:8000007 @@ -304194,8 +424172,8 @@ is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum intersection_of: in_right_side_of UBERON:0000468 ! multicellular organism +relationship: dc-contributor https://orcid.org/0000-0001-5208-3432 relationship: in_right_side_of UBERON:0000468 ! multicellular organism -created_by: http://orcid.org/0000-0001-5208-3432 [Term] id: UBERON:8000009 @@ -304205,9 +424183,464 @@ def: "A collection of Purkinje fibers that receives signals from the right and l synonym: "Purkinje fibre network" EXACT [PMID:26786210] is_a: UBERON:0010131 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle +relationship: dc-contributor https://orcid.org/0000-0001-5208-3432 relationship: has_part UBERON:0002354 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! cardiac Purkinje fiber relationship: part_of UBERON:0004146 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! His-Purkinje system -created_by: http://orcid.org/0000-0001-5208-3432 + +[Term] +id: UBERON:8300001 +name: right forelimb +is_a: UBERON:0002102 ! forelimb +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002102 ! forelimb +intersection_of: in_right_side_of UBERON:0010708 ! pectoral complex +relationship: in_right_side_of UBERON:0010708 ! pectoral complex + +[Term] +id: UBERON:8300002 +name: left forelimb +is_a: UBERON:0002102 ! forelimb +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002102 ! forelimb +intersection_of: in_left_side_of UBERON:0010708 ! pectoral complex +relationship: in_left_side_of UBERON:0010708 ! pectoral complex + +[Term] +id: UBERON:8300003 +name: right hindlimb +is_a: UBERON:0002103 ! hindlimb +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002103 ! hindlimb +intersection_of: in_right_side_of UBERON:0010709 ! pelvic complex +relationship: in_right_side_of UBERON:0010709 ! pelvic complex + +[Term] +id: UBERON:8300004 +name: left hindlimb +is_a: UBERON:0002103 ! hindlimb +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002103 ! hindlimb +intersection_of: in_left_side_of UBERON:0010709 ! pelvic complex +relationship: in_left_side_of UBERON:0010709 ! pelvic complex + +[Term] +id: UBERON:8400021 +name: liver serosa +namespace: uberon +def: "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." [https://medical-dictionary.thefreedictionary.com/serosa+of+liver, https://orcid.org/0000-0002-0449-2730] +synonym: "serosa of liver" EXACT [FMA:15811] +synonym: "tunica serosa hepatis" EXACT [https://medical-dictionary.thefreedictionary.com/serosa+of+liver] {synonymtypedef="LATIN"} +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: part_of UBERON:0002107 ! liver +relationship: dc-contributor https://orcid.org/0000-0003-2034-601X +relationship: part_of UBERON:0002107 ! liver + +[Term] +id: UBERON:8400023 +name: liver subserosa +namespace: uberon +def: "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." [FMA:15812, https://medical-dictionary.thefreedictionary.com/subserosa+of+liver, https://orcid.org/0000-0002-0449-2730] +synonym: "hepatic subserosa" EXACT [] +synonym: "subserosal tissue of liver" EXACT [] +synonym: "subserous layer of liver" EXACT [] +synonym: "tela subserosa (hepar)" EXACT [FMA:15821] +synonym: "tela subserosa hepatis" EXACT [https://medical-dictionary.thefreedictionary.com/subserosa+of+liver] +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0012375 ! subserosa +intersection_of: UBERON:0012375 ! subserosa +intersection_of: part_of UBERON:0002107 ! liver +relationship: dc-contributor https://orcid.org/0000-0003-2034-601X +relationship: part_of UBERON:0002107 ! liver + +[Term] +id: UBERON:8400024 +name: subcapsular region of liver +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: adjacent_to UBERON:0016479 ! capsule of liver +intersection_of: part_of UBERON:0002107 ! liver +relationship: adjacent_to UBERON:0016479 ! capsule of liver + +[Term] +id: UBERON:8410000 +name: duodeno-jejunal junction +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0002114 ! duodenum +intersection_of: connects UBERON:0002115 ! jejunum +relationship: connects UBERON:0002114 ! duodenum +relationship: connects UBERON:0002115 ! jejunum +relationship: part_of UBERON:0002108 ! small intestine + +[Term] +id: UBERON:8410001 +name: small intestine venule +namespace: uberon +def: "Venule of villus of small intestine." [https://orcid.org/0000-0003-4183-8865] +subset: location_grouping +synonym: "venule of small intestine" EXACT [] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:0001213 ! intestinal villus +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001213 ! intestinal villus + +[Term] +id: UBERON:8410002 +name: small intestine lymphatic vessel +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: part_of UBERON:0002108 ! small intestine + +[Term] +id: UBERON:8410004 +name: small intestine arteriole +namespace: uberon +def: "Arteriole of villus of small intestine." [http://orcid.org/0000-0003-4183-8865/] +subset: location_grouping +synonym: "arteriole of small intestine" EXACT [] +synonym: "arteriole of villus of small intestine" EXACT [] +synonym: "small intestine villus arteriole" EXACT [] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0001213 ! intestinal villus +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001213 ! intestinal villus + +[Term] +id: UBERON:8410008 +name: venule of anorectum +namespace: uberon +def: "A venule that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +synonym: "anorectum venule" EXACT [] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:8410050 ! anorectum + +[Term] +id: UBERON:8410009 +name: arteriole of anorectum +namespace: uberon +def: "An arteriole that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +synonym: "anorectum arteriole" EXACT [] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:8410050 ! anorectum + +[Term] +id: UBERON:8410015 +name: arteriole of colon +namespace: uberon +def: "An arteriole located in the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865/] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0001155 ! colon +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001155 ! colon + +[Term] +id: UBERON:8410016 +name: descending sigmoid junction +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0001158 ! descending colon +intersection_of: connects UBERON:0001159 ! sigmoid colon +relationship: connects UBERON:0001158 ! descending colon +relationship: connects UBERON:0001159 ! sigmoid colon +relationship: part_of UBERON:0000168 ! proximal-distal subdivision of colon + +[Term] +id: UBERON:8410017 +name: left colic vein +is_a: UBERON:0002017 ! portal vein +intersection_of: UBERON:0002017 ! portal vein +intersection_of: drains UBERON:0001158 ! descending colon +intersection_of: tributary_of UBERON:0001215 ! inferior mesenteric vein +relationship: drains UBERON:0001158 ! descending colon +relationship: tributary_of UBERON:0001215 ! inferior mesenteric vein + +[Term] +id: UBERON:8410018 +name: right colic vein +is_a: UBERON:0002017 ! portal vein +intersection_of: UBERON:0002017 ! portal vein +intersection_of: drains UBERON:0001156 ! ascending colon +intersection_of: tributary_of UBERON:0001138 ! superior mesenteric vein +relationship: drains UBERON:0001156 ! ascending colon +relationship: tributary_of UBERON:0001138 ! superior mesenteric vein + +[Term] +id: UBERON:8410019 +name: jejuno-ileal junction +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0002115 ! jejunum +intersection_of: connects UBERON:0002116 ! ileum +relationship: connects UBERON:0002115 ! jejunum +relationship: connects UBERON:0002116 ! ileum +relationship: part_of UBERON:0002108 ! small intestine + +[Term] +id: UBERON:8410020 +name: venule of appendix +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:8410021 +name: inguinal region skin +is_a: UBERON:0003836 ! abdominal segment skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: part_of UBERON:0008337 ! inguinal part of abdomen +relationship: part_of UBERON:0008337 ! inguinal part of abdomen + +[Term] +id: UBERON:8410024 +name: intestinal junction +namespace: uberon +def: "An anatomical junction between two parts of the intestine." [https://orcid.org/0000-0002-7073-9172] +synonym: "junction of intestine" EXACT [] +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: connects UBERON:0004921 ! subdivision of digestive tract +intersection_of: part_of UBERON:0000160 ! intestine +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0000160 ! intestine + +[Term] +id: UBERON:8410028 +name: arteriole of appendix +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:8410030 +name: lymphatic vessel of appendix +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:8410032 +name: trabecular sinus of lymph node +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: adjacent_to UBERON:0002195 ! trabecula of lymph node +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: adjacent_to UBERON:0002195 ! trabecula of lymph node +relationship: part_of UBERON:0000029 ! lymph node + +[Term] +id: UBERON:8410033 +name: lymph node vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: drains UBERON:0000029 ! lymph node +relationship: drains UBERON:0000029 ! lymph node + +[Term] +id: UBERON:8410034 +name: lymph node artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: supplies UBERON:0000029 ! lymph node +relationship: supplies UBERON:0000029 ! lymph node + +[Term] +id: UBERON:8410035 +name: medullary arteriole of lymph node +is_a: UBERON:8410042 ! arteriole of lymph node +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0002007 ! medulla of lymph node +relationship: branching_part_of UBERON:8410034 ! lymph node artery +relationship: part_of UBERON:0002007 ! medulla of lymph node + +[Term] +id: UBERON:8410036 +name: medullary venule of lymph node +is_a: UBERON:8410041 ! venule of lymph node +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:0002007 ! medulla of lymph node +relationship: part_of UBERON:0002007 ! medulla of lymph node + +[Term] +id: UBERON:8410041 +name: venule of lymph node +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: part_of UBERON:0000029 ! lymph node + +[Term] +id: UBERON:8410042 +name: arteriole of lymph node +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: part_of UBERON:0000029 ! lymph node +relationship: part_of UBERON:0000029 ! lymph node + +[Term] +id: UBERON:8410043 +name: bronchus submucosal gland +namespace: uberon +def: "A submucosal gland located in a bronchus." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +subset: human_reference_atlas +synonym: "airway submucosal gland" BROAD [] +synonym: "bronchial submucosal gland" EXACT [] +synonym: "submucosal bronchial gland" EXACT [] +synonym: "submucosal bronchus gland" EXACT [] +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: part_of UBERON:0002185 ! bronchus +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0002185 ! bronchus +property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:8410044 +name: vein of appendix +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:8410045 +name: artery of appendix +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: part_of UBERON:0001154 ! vermiform appendix +relationship: part_of UBERON:0001154 ! vermiform appendix + +[Term] +id: UBERON:8410048 +name: venule of colon +namespace: uberon +def: "A venule located in the colon." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: part_of UBERON:0001155 ! colon +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001155 ! colon + +[Term] +id: UBERON:8410049 +name: serosal nerve fiber of appendix +is_a: UBERON:0006134 ! nerve fiber +intersection_of: UBERON:0006134 ! nerve fiber +intersection_of: part_of UBERON:0012498 ! serosa of appendix +relationship: part_of UBERON:0012498 ! serosa of appendix + +[Term] +id: UBERON:8410050 +name: anorectum +namespace: uberon +def: "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." [DOI:10.1007/978-3-319-26938-2_8, DOI:10.1148/rg.2015150037, http://orcid.org/0000-0002-6826-8770, http://orcid.org/0000-0003-3440-1876, PMID:29742860] +synonym: "anorectal canal" NARROW [] +is_a: UBERON:0004921 ! subdivision of digestive tract +intersection_of: UBERON:0004921 ! subdivision of digestive tract +intersection_of: has_part UBERON:0000159 ! anal canal +intersection_of: has_part UBERON:0001052 ! rectum +intersection_of: has_part UBERON:0001245 ! anus +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: has_part UBERON:0000159 ! anal canal +relationship: has_part UBERON:0001052 ! rectum +relationship: has_part UBERON:0001245 ! anus +relationship: part_of UBERON:0000059 ! large intestine +property_value: editor_note "The anatomy, pathology and medical community considers the anus to be part of the large intestine, and supports the use of 'anorectum' to include rectum, anal canal and anus. Although a few resources seem to only include the distal part of the rectum in 'anorectum', this UBERON grouping term is meant to refer more broadly to the whole of rectum." xsd:string +property_value: RO:0002175 NCBITaxon:9606 +property_value: UBPROP:0000007 "anorectal" xsd:string + +[Term] +id: UBERON:8410051 +name: lymphatic vessel of colon +is_a: UBERON:0001473 ! lymphatic vessel +intersection_of: UBERON:0001473 ! lymphatic vessel +intersection_of: part_of UBERON:0001155 ! colon +relationship: part_of UBERON:0001155 ! colon + +[Term] +id: UBERON:8410056 +name: capillary of anorectum +namespace: uberon +def: "A capillary that is part of the anorectum." [http://orcid.org/0000-0003-3440-1876] +synonym: "blood vessel capillary of anorectum" EXACT [] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: part_of UBERON:8410050 ! anorectum +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:8410050 ! anorectum + +[Term] +id: UBERON:8410057 +name: capillary of colon +namespace: uberon +def: "A capillary that is part of the colon." [http://orcid.org/0000-0003-3440-1876] +synonym: "blood vessel capillary of colon" EXACT [] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: part_of UBERON:0001155 ! colon +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0001155 ! colon + +[Term] +id: UBERON:8410068 +name: capillary of small intestine +namespace: uberon +def: "A capillary that is part of a small intestine." [http://orcid.org/0000-0003-3440-1876] +subset: location_grouping +synonym: "blood vessel capillary of small intestine" EXACT [] +synonym: "small intestine capillary" EXACT [] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: part_of UBERON:0002108 ! small intestine +relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0002108 ! small intestine +property_value: http://purl.org/dc/terms/date 2021-12-21T15:14:31Z xsd:dateTime + +[Term] +id: UBERON:8410077 +name: airway submucosal gland +namespace: uberon +def: "A submucosal gland found in a respiratory tract." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +synonym: "respiratory tract submucosal gland" EXACT [] +synonym: "submucosal gland of respiratory tract" EXACT [] +xref: EFO:0010666 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011148 ! submucosal gland +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: part_of UBERON:0000065 ! respiratory tract +relationship: dc-contributor http://orcid.org/0000-0002-2825-0621 +relationship: part_of UBERON:0000065 ! respiratory tract +property_value: http://purl.org/dc/terms/date 2022-03-24T14:21:59Z xsd:dateTime + +[Term] +id: UBERON:8410081 +name: blood microvessel +namespace: uberon +def: "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." [http://orcid.org/0000-0002-7073-9172, Wikipedia:Microcirculation] +synonym: "microvasculature" BROAD [] +synonym: "microvessel" BROAD [] +is_a: UBERON:0001981 ! blood vessel +is_a: UBERON:0010523 ! microcirculatory vessel +property_value: seeAlso https://github.com/obophenotype/uberon/issues/2186 xsd:string +property_value: UBPROP:0000007 "microvascular" xsd:string +created_by: http://orcid.org/0000-0002-2825-0621 [Term] id: UBERON:8440004 @@ -304215,6 +424648,322 @@ name: laminar subdivision of the cortex namespace: uberon def: "One or a subset of adjacent layers of the neocortex." [ISBN-10:0-87893-742-0] is_a: UBERON:0011215 ! central nervous system cell part cluster +relationship: part_of UBERON:0001950 ! neocortex + +[Term] +id: UBERON:8440011 +name: cortical visual area +namespace: uberon +def: "The part of the cortex that is responsible for processing visual information." [https://orcid.org/0000-0001-7258-9596] +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +is_a: UBERON:0035014 ! functional part of brain +relationship: dc-contributor http://orcid.org/0000-0001-7258-9596 +relationship: part_of UBERON:0000956 ! cerebral cortex + +[Term] +id: UBERON:8440015 +name: noradrenergic cell groups +namespace: uberon +def: "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." [WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184] +is_a: UBERON:0002616 ! regional part of brain +relationship: composed_primarily_of CL:0000459 ! noradrenergic cell + +[Term] +id: UBERON:8450001 +name: egg follicle +namespace: uberon +def: "An individual reproductive unit containing a single oocyte and one or several layers of support cells (Armstrong et al., 2020)." [DOI:10.1530/REP-18-0593] +is_a: CARO:0000000 ! anatomical entity +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0005156 ! reproductive structure +relationship: dc-contributor http://orcid.org/0000-0002-6095-8718 +relationship: part_of UBERON:0000992 ! ovary +property_value: http://purl.org/dc/terms/date 2022-04-19T11:08:10Z xsd:dateTime +property_value: seeAlso https://github.com/obophenotype/uberon/issues/476 xsd:anyURI + +[Term] +id: UBERON:8470000 +name: placental blood +namespace: uberon +def: "Blood located in the placenta." [http://orcid.org/0000-0001-6595-0902, https://www.ncbi.nlm.nih.gov/books/NBK53254/] +is_a: UBERON:0000178 ! blood +intersection_of: UBERON:0000178 ! blood +intersection_of: located_in UBERON:0001987 ! placenta +relationship: dc-contributor http://orcid.org/0000-0002-1773-2692 +relationship: located_in UBERON:0001987 ! placenta +property_value: http://purl.org/dc/terms/date 2022-04-04T11:06:09Z xsd:dateTime + +[Term] +id: UBERON:8480001 +name: capillary of brain +namespace: uberon +def: "A capillary that is part of the brain." [https://orcid.org/0000-0002-0819-0473] +is_a: UBERON:0001982 ! capillary +is_a: UBERON:0003499 ! brain blood vessel +intersection_of: UBERON:0001982 ! capillary +intersection_of: part_of UBERON:0000955 ! brain +relationship: dc-contributor http://orcid.org/0000-0002-0819-0473 +property_value: http://purl.org/dc/terms/date 2022-06-24T09:28:31Z xsd:dateTime + +[Term] +id: UBERON:8480002 +name: thoracic aorta smooth muscle tissue +namespace: uberon +def: "A portion of smooth muscle tissue that is part of the thoracic aorta." [https://orcid.org/0000-0002-0819-0473] +is_a: UBERON:0004178 ! aorta smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: part_of UBERON:0001515 ! thoracic aorta +relationship: dc-contributor http://orcid.org/0000-0002-0819-0473 +relationship: part_of UBERON:0001515 ! thoracic aorta +property_value: http://purl.org/dc/terms/date 2022-06-24T09:30:54Z xsd:dateTime + +[Term] +id: UBERON:8480005 +name: placental artery endothelium +namespace: uberon +def: "An endothelium that is part of the placental artery." [https://orcid.org/0000-0002-0819-0473] +is_a: UBERON:0001917 ! endothelium of artery +is_a: UBERON:0005156 ! reproductive structure +is_a: UBERON:0005292 ! extraembryonic tissue +intersection_of: UBERON:0001986 ! endothelium +intersection_of: part_of UBERON:8480007 ! placental artery +relationship: dc-contributor http://orcid.org/0000-0002-0819-0473 +relationship: part_of UBERON:8480007 ! placental artery +property_value: http://purl.org/dc/terms/date 2022-06-24T09:34:25Z xsd:dateTime + +[Term] +id: UBERON:8480007 +name: placental artery +namespace: uberon +def: "An artery that is part of the placenta." [https://orcid.org/0000-0002-0819-0473] +is_a: UBERON:0001637 ! artery +is_a: UBERON:0022358 ! placenta blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: part_of UBERON:0001987 ! placenta +relationship: dc-contributor http://orcid.org/0000-0002-0819-0473 +property_value: http://purl.org/dc/terms/date 2022-06-24T11:25:24Z xsd:dateTime + +[Term] +id: UBERON:8480008 +name: placental vein +namespace: uberon +def: "A vein that is part of the placenta." [https://orcid.org/0000-0002-0819-0473] +is_a: UBERON:0001638 ! vein +is_a: UBERON:0022358 ! placenta blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: part_of UBERON:0001987 ! placenta +relationship: dc-contributor http://orcid.org/0000-0002-0819-0473 +property_value: http://purl.org/dc/terms/date 2022-06-27T09:30:52Z xsd:dateTime + +[Term] +id: UPHENO:0001001 +name: phenotype +is_a: PATO:0000001 ! quality + +[Term] +id: http://identifiers.org/hgnc/10683 +name: SDHD +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/11138 +name: SNCA +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/11998 +name: TP53 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/12014 +name: TPMT +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/16783 +name: CDC73 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/4851 +name: HTT +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/5973 +name: IL13 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/7106 +name: ATXN3 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/8149 +name: OPLAH +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/8618 +name: PAX4 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/8620 +name: PAX6 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/hgnc/989 +name: BCL10 +is_a: SO:0000704 ! gene + +[Typedef] +id: BFO:0000052 +name: inheres in at all times +property_value: TV_pl "BFO_0000052" xsd:string +property_value: TV_sg "BFO_0000052s" xsd:string +property_value: TV_vbg "BFO_0000052ed" xsd:string + +[Typedef] +id: BFO:0000055 +name: realizes +property_value: TV_pl "BFO_0000055" xsd:string +property_value: TV_sg "BFO_0000055s" xsd:string +property_value: TV_vbg "BFO_0000055ed" xsd:string +domain: BFO:0000015 ! process +range: BFO:0000017 ! realizable entity + +[Typedef] +id: BFO:0000057 +name: has participant at some time +property_value: TV_pl "BFO_0000057" xsd:string +property_value: TV_sg "BFO_0000057s" xsd:string +property_value: TV_vbg "BFO_0000057ed" xsd:string +holds_over_chain: BFO:0000055 BFO:0000052 + +[Typedef] +id: BFO:0000117 +name: has occurrent part +property_value: TV_pl "BFO_0000117" xsd:string +property_value: TV_sg "BFO_0000117s" xsd:string +property_value: TV_vbg "BFO_0000117ed" xsd:string +is_transitive: true +inverse_of: BFO:0000132 ! part of occurrent + +[Typedef] +id: BFO:0000132 +name: part of occurrent +property_value: TV_pl "BFO_0000132" xsd:string +property_value: TV_sg "BFO_0000132s" xsd:string +property_value: TV_vbg "BFO_0000132ed" xsd:string +is_transitive: true + +[Typedef] +id: BFO:0000167 +name: has participant at all times +property_value: TV_pl "BFO_0000167" xsd:string +property_value: TV_sg "BFO_0000167s" xsd:string +property_value: TV_vbg "BFO_0000167ed" xsd:string + +[Typedef] +id: IAO:0000136 +name: is about +def: "A (currently) primitive relation that relates an information artifact to an entity." [] +def: "is_about is a (currently) primitive relation that relates an information artifact to an entity." [] +domain: IAO:0000030 ! information content entity + +[Typedef] +id: MONDO:0100332 +name: disease has primary infectious agent +is_a: disease_has_infectious_agent ! disease has infectious agent +created_by: https://orcid.org/0000-0001-5208-3432 + +[Typedef] +id: OBI:0000293 +name: has_specified_input +def: "A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." [] +domain: OBI:0000011 ! planned process +is_a: has_participant ! has participant +inverse_of: OBI:0000295 ! is_specified_input_of + +[Typedef] +id: OBI:0000295 +name: is_specified_input_of +def: "A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of." [] +range: OBI:0000011 ! planned process +is_a: participates_in ! participates in + +[Typedef] +id: OBI:0000299 +name: has_specified_output +def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." [] +domain: OBI:0000011 ! planned process +is_a: has_participant ! has participant +inverse_of: OBI:0000312 ! is_specified_output_of + +[Typedef] +id: OBI:0000312 +name: is_specified_output_of +def: "A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of." [] +range: OBI:0000011 ! planned process +is_a: participates_in ! participates in + +[Typedef] +id: OBI:0000417 +name: achieves_planned_objective +def: "This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process." [] +domain: OBI:0000011 ! planned process +range: IAO:0000005 ! objective specification +inverse_of: OBI:0000833 ! objective_achieved_by + +[Typedef] +id: OBI:0000833 +name: objective_achieved_by +def: "This relation obtains between a a objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process." [] +def: "This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process." [] +domain: IAO:0000005 ! objective specification +range: OBI:0000011 ! planned process + +[Typedef] +id: RO:0000052 +name: characteristic of +name: inheres in +def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] +def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] +comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. +property_value: editor_note "A dependent inheres in its bearer at all times for which the dependent exists." xsd:string +property_value: IAO:0000111 "inheres in" xsd:string +property_value: IAO:0000112 "this fragility inheres in this vase" xsd:string +property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string +property_value: IAO:0000112 "this red color inheres in this apple" xsd:string +property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string +property_value: IAO:0000118 "inheres_in" xsd:string +property_value: RO:0001900 RO:0001901 +is_functional: true +is_a: RO:0002314 ! inheres in part -of +inverse_of: bearer_of ! bearer of + +[Typedef] +id: RO:0000058 +name: is concretized as +def: "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants." [] +property_value: IAO:0000112 "A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The journal article (a generically dependent continuant) is concretized as the quality (a specifically dependent continuant), and both depend on that copy of the printed journal (an independent continuant)." xsd:string +property_value: IAO:0000112 "An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process)." xsd:string +domain: BFO:0000031 ! generically dependent continuant +range: BFO:0000020 ! specifically dependent continuant +inverse_of: RO:0000059 ! concretizes + +[Typedef] +id: RO:0000059 +name: concretizes +def: "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant." [] +property_value: IAO:0000112 "A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant)." xsd:string +property_value: IAO:0000112 "An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process)." xsd:string +domain: BFO:0000020 ! specifically dependent continuant +range: BFO:0000031 ! generically dependent continuant [Typedef] id: RO:0000079 @@ -304226,7 +424975,7 @@ property_value: IAO:0000112 "this catalysis function is a function of this enzym property_value: IAO:0000118 "function_of" xsd:string property_value: IAO:0000118 "is function of" xsd:string domain: BFO:0000034 ! function -is_a: inheres_in ! inheres in +is_a: RO:0000052 ! inheres in inverse_of: RO:0000085 ! has function [Typedef] @@ -304238,7 +424987,7 @@ property_value: editor_note "A quality inheres in its bearer at all times for wh property_value: IAO:0000112 "this red color is a quality of this apple" xsd:string property_value: IAO:0000118 "is quality of" xsd:string property_value: IAO:0000118 "quality_of" xsd:string -is_a: inheres_in ! inheres in +is_a: RO:0000052 ! inheres in inverse_of: has_quality ! has quality [Typedef] @@ -304250,7 +424999,7 @@ property_value: editor_note "A role inheres in its bearer at all times for which property_value: IAO:0000112 "this investigator role is a role of this person" xsd:string property_value: IAO:0000118 "is role of" xsd:string property_value: IAO:0000118 "role_of" xsd:string -is_a: inheres_in ! inheres in +is_a: RO:0000052 ! inheres in inverse_of: has_role ! has role [Typedef] @@ -304279,7 +425028,17 @@ name: disposition of def: "inverse of has disposition" [] comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. subset: RO:0002259 -is_a: inheres_in ! inheres in +is_a: RO:0000052 ! inheres in + +[Typedef] +id: RO:0001001 +name: derives into +def: "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] +property_value: editor_note "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'." xsd:string +property_value: IAO:0000112 "this parent cell derives into this cell (cell division)" xsd:string +property_value: IAO:0000112 "this parent nucleus derives into this nucleus (nuclear division)" xsd:string +property_value: IAO:0000114 IAO:0000125 +property_value: IAO:0000118 "derives_into" xsd:string [Typedef] id: RO:0001018 @@ -304297,12 +425056,20 @@ holds_over_chain: located_in part_of inverse_of: contains ! contains [Typedef] -id: RO:0002011 -name: regulates transport of -def: "A relationship that holds between a process that regulates a transport process and the entity transported by that process." [] -subset: ro-eco -property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string -holds_over_chain: regulates transports_or_maintains_localization_of +id: RO:0002000 +name: 2D boundary of +def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" [] +property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string +property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string +property_value: IAO:0000112 "the surface of my skin is a 2D boundary of my body" xsd:string +property_value: IAO:0000118 "2D_boundary_of" xsd:string +property_value: IAO:0000118 "boundary of" xsd:string +property_value: IAO:0000118 "is 2D boundary of" xsd:string +property_value: IAO:0000118 "is boundary of" xsd:string +property_value: IAO:0000118 "surface of" xsd:string +property_value: RO:0001900 RO:0001901 +is_a: RO:0002323 ! mereotopologically related to +inverse_of: has_boundary ! has 2D boundary [Typedef] id: RO:0002015 @@ -304332,6 +425099,14 @@ is_a: has_component ! has component created_by: dos creation_date: 2017-05-24T09:49:21Z +[Typedef] +id: RO:0002021 +name: occurs across +def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." [] +is_a: RO:0002479 ! has part that occurs in +created_by: dos +creation_date: 2017-07-20T17:19:37Z + [Typedef] id: RO:0002022 name: directly regulated by @@ -304396,10 +425171,18 @@ property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: RO:0001900 RO:0001901 domain: CL:0000540 ! neuron +range: CARO:0000003 ! connected anatomical structure is_a: overlaps ! overlaps transitive_over: part_of ! part_of expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" [] +[Typedef] +id: RO:0002103 +name: synapsed by +def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " [] +is_a: RO:0002485 ! receives input from +inverse_of: RO:0002120 ! synapsed to + [Typedef] id: RO:0002104 name: has plasma membrane part @@ -304411,9 +425194,41 @@ property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Lindsay Cowell" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/19243617 property_value: RO:0001900 RO:0001901 +domain: CARO:0000006 ! material anatomical entity +range: CARO:0000006 ! material anatomical entity is_a: has_part ! has_part expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" [] +[Typedef] +id: RO:0002120 +name: synapsed to +def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " [] +is_a: RO:0002486 ! sends output to + +[Typedef] +id: RO:0002156 +name: derived by descent from +def: "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." [] +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to +inverse_of: RO:0002157 ! has derived by descendant + +[Typedef] +id: RO:0002157 +name: has derived by descendant +def: "inverse of derived by descent from" [] +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002158 +name: shares ancestor with +def: "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." [] +holds_over_chain: RO:0002156 RO:0002157 +is_symmetric: true +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to + [Typedef] id: RO:0002163 name: spatially disjoint from @@ -304429,6 +425244,20 @@ property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Part-disjoin is_a: RO:0002323 ! mereotopologically related to expand_expression_to: "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" [] +[Typedef] +id: RO:0002200 +name: has phenotype +def: "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." [] +range: UPHENO:0001001 ! phenotype +is_a: RO:0016001 ! has phenotype or disease +inverse_of: RO:0002201 ! phenotype of + +[Typedef] +id: RO:0002201 +name: phenotype of +def: "inverse of has phenotype" [] +is_functional: true + [Typedef] id: RO:0002210 name: directly develops into @@ -304451,6 +425280,13 @@ property_value: IAO:0000232 "Do not use this relation directly. It is ended as a domain: BFO:0000003 ! occurrent range: BFO:0000003 ! occurrent +[Typedef] +id: RO:0002244 +name: related via exposure to +def: "Any relationship between an exposure event or process and any other entity." [] +domain: RO:0002310 ! exposure event or process +is_a: RO:0002410 ! causally related to + [Typedef] id: RO:0002257 name: developmentally induces @@ -304498,12 +425334,55 @@ property_value: IAO:0000117 "Chris Mungall" xsd:string holds_over_chain: part_of RO:0002210 is_a: RO:0002286 ! developmentally succeeded by +[Typedef] +id: RO:0002303 +name: has habitat +def: "x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs." [] +domain: CARO:0001010 ! organism or virus or viroid +range: ENVO:01000254 ! environmental system +is_a: RO:0002321 ! ecologically related to + +[Typedef] +id: RO:0002309 +name: has exposure stimulus +def: "A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event." [] +is_a: RO:0002244 ! related via exposure to + +[Typedef] +id: RO:0002314 +name: characteristic of part of +name: inheres in part -of +name: inheres in part of +def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] +def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." [] +property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string +property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" xsd:string +property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000118 "inheres in part of" xsd:string +property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 +property_value: RO:0001900 RO:0001901 +property_value: seeAlso "defining-property-chains-involving-reflexivity" +property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ +holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} +is_a: RO:0002502 ! depends on +transitive_over: part_of ! part_of + [Typedef] id: RO:0002320 name: evolutionarily related to def: "A relationship that holds via some environmental process" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution." xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl + +[Typedef] +id: RO:0002321 +name: ecologically related to +def: "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" [] +subset: ro-eco +property_value: editor_note "Awaiting class for domain/range constraint, see: https://github.com/OBOFoundry/Experimental-OBO-Core/issues/6" xsd:string +property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000232 "Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving ecological interactions" xsd:string [Typedef] id: RO:0002323 @@ -304511,6 +425390,7 @@ name: mereotopologically related to def: "A mereological relationship or a topological relationship" [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 [Typedef] @@ -304533,11 +425413,20 @@ property_value: IAO:0000118 "is catalyzing" xsd:string property_value: IAO:0000118 "is executing" xsd:string property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string property_value: IAO:0000232 "This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time." xsd:string -is_a: capable_of ! capable of +is_a: capable_of ! capable_of inverse_of: RO:0002333 ! enabled by transitive_over: has_part ! has_part transitive_over: RO:0002017 ! has component activity +[Typedef] +id: RO:0002329 +name: part of structure that is capable of +def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] +property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000118 "false" xsd:boolean +holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"} +is_a: functionally_related_to ! functionally related to + [Typedef] id: RO:0002331 name: involved in @@ -304575,6 +425464,13 @@ name: formed as result of property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: output_of ! output of +[Typedef] +id: RO:0002374 +name: derived from ancestral fusion of +def: "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat" [] +synonym: "has fused element" BROAD [] +is_a: RO:0002156 ! derived by descent from + [Typedef] id: RO:0002375 name: in branching relationship with @@ -304583,11 +425479,11 @@ property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships" xsd:string property_value: IAO:0000232 "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)" xsd:string +property_value: RO:0004036 BFO:0000050 property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/branching_part_of.png property_value: seeAlso https://github.com/obophenotype/uberon/issues/170 xsd:anyURI domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity -is_a: part_of ! part_of is_a: RO:0002323 ! mereotopologically related to [Typedef] @@ -304617,6 +425513,14 @@ property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving +[Typedef] +id: RO:0002388 +name: has potential to directly develop into +def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] +property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000117 "Chris Mungall" xsd:string +is_a: has_potential_to_develop_into ! has potential to develop into + [Typedef] id: RO:0002410 name: causally related to @@ -304776,6 +425680,17 @@ name: is kinase activity property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002564 ! molecular interaction relation helper property +[Typedef] +id: RO:0002485 +name: receives input from +is_a: connected_to ! connected to +inverse_of: RO:0002486 ! sends output to + +[Typedef] +id: RO:0002486 +name: sends output to +is_a: connected_to ! connected to + [Typedef] id: RO:0002487 name: relation between physical entity and a process or stage @@ -304837,6 +425752,33 @@ domain: BFO:0000002 ! continuant range: BFO:0000002 ! continuant is_a: RO:0002410 ! causally related to +[Typedef] +id: RO:0002507 +name: determined by +def: "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." [] +domain: RO:0002577 ! system +range: BFO:0000040 ! material entity +is_a: part_of ! part_of +is_a: RO:0002509 ! determined by part of +is_a: RO:0002559 ! causally influenced by +inverse_of: RO:0002508 ! determines + +[Typedef] +id: RO:0002508 +name: determines +def: "inverse of determined by" [] +is_a: RO:0002566 ! causally influences + +[Typedef] +id: RO:0002509 +name: determined by part of +def: "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." [] +domain: RO:0002577 ! system +range: BFO:0000040 ! material entity +holds_over_chain: RO:0002507 part_of +is_a: overlaps ! overlaps +is_a: RO:0002506 ! causal relation between entities + [Typedef] id: RO:0002559 name: causally influenced by @@ -304879,6 +425821,8 @@ name: biomechanically related to def: "A relation that holds between elements of a musculoskeletal system or its analogs." [] property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." xsd:string +domain: CARO:0000003 ! connected anatomical structure +range: CARO:0000003 ! connected anatomical structure is_a: functionally_related_to ! functionally related to [Typedef] @@ -304980,6 +425924,61 @@ property_value: RO:0004050 RO:0002578 is_a: negatively_regulates ! negatively regulates is_a: RO:0002578 ! directly regulates +[Typedef] +id: RO:0003302 +name: causes or contributes to condition +def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition." [] +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0003303 +name: causes condition +def: "A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition." [] +is_a: RO:0003302 ! causes or contributes to condition + +[Typedef] +id: RO:0004000 +name: condition has genetic basis in +domain: BFO:0000017 ! realizable entity +is_a: RO:0002410 ! causally related to +inverse_of: RO:0004010 ! is genetic basis for condition + +[Typedef] +id: RO:0004010 +name: is genetic basis for condition +range: BFO:0000017 ! realizable entity +is_a: RO:0004018 ! is basis for realizable + +[Typedef] +id: RO:0004013 +name: is causal germline mutation in +def: "Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]." [] +is_a: RO:0003303 ! causes condition +is_a: RO:0004010 ! is genetic basis for condition + +[Typedef] +id: RO:0004017 +name: realizable has basis in +is_a: RO:0002410 ! causally related to +inverse_of: RO:0004018 ! is basis for realizable + +[Typedef] +id: RO:0004018 +name: is basis for realizable +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0004019 +name: disease has basis in +is_a: RO:0004017 ! realizable has basis in +is_a: RO:0004023 ! causal relationship with disease as subject + +[Typedef] +id: RO:0004023 +name: causal relationship with disease as subject +is_a: RO:0002410 ! causally related to +is_a: RO:0040035 ! disease relationship + [Typedef] id: RO:0004031 name: enables subfunction @@ -305052,6 +426051,24 @@ is_a: causally_upstream_of_or_within ! causally upstream of or within created_by: cjm creation_date: 2018-03-13T23:55:19Z +[Typedef] +id: RO:0010001 +name: generically depends on +def: "A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*." [] +synonym: "g-depends on" EXACT [] +domain: BFO:0000031 ! generically dependent continuant +range: BFO:0000004 ! independent continuant +holds_over_chain: RO:0000052 RO:0000058 +inverse_of: RO:0010002 ! is carrier of + +[Typedef] +id: RO:0010002 +name: is carrier of +def: "*b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t*" [] +domain: BFO:0000004 ! independent continuant +range: BFO:0000031 ! generically dependent continuant +holds_over_chain: RO:0000059 bearer_of + [Typedef] id: RO:0011002 name: regulates activity of @@ -305061,17 +426078,86 @@ domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_a: RO:0002566 ! causally influences +[Typedef] +id: RO:0015006 +name: different in magnitude relative to +def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] +domain: PATO:0000001 ! quality +range: PATO:0000001 ! quality + +[Typedef] +id: RO:0015007 +name: increased in magnitude relative to +def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] +comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. +domain: PATO:0000001 ! quality +range: PATO:0000001 ! quality +is_a: RO:0015006 ! different in magnitude relative to + +[Typedef] +id: RO:0015008 +name: decreased in magnitude relative to +def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [https://orcid.org/0000-0002-6601-2165] +comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. +domain: PATO:0000001 ! quality +range: PATO:0000001 ! quality +is_a: RO:0015006 ! different in magnitude relative to + +[Typedef] +id: RO:0015011 +name: has cross section +def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [https://orcid.org/0000-0002-6601-2165] +comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. + +[Typedef] +id: RO:0015012 +name: reciprocal of +def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [https://orcid.org/0000-0002-6601-2165] +comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. + +[Typedef] +id: RO:0015015 +name: has high plasma membrane amount +def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." [PMID:19243617] +property_value: dc-contributor http://orcid.org/0000-0003-1617-8244 +property_value: dc-contributor http://orcid.org/0000-0003-1940-6740 +property_value: IAO:0000112 "'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')" xsd:string +domain: CL:0000000 ! cell +is_a: RO:0002104 ! has plasma membrane part + +[Typedef] +id: RO:0015016 +name: has low plasma membrane amount +def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." [PMID:19243617] +property_value: dc-contributor http://orcid.org/0000-0003-1617-8244 +property_value: dc-contributor http://orcid.org/0000-0003-1940-6740 +property_value: IAO:0000112 "'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')" xsd:string +domain: CL:0000000 ! cell +is_a: RO:0002104 ! has plasma membrane part + +[Typedef] +id: RO:0016001 +name: has phenotype or disease + [Typedef] id: RO:0017001 +name: device utilizes material name: utilizes +def: "X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y." [] def: "X utilizes Y means X and Y are material entities, and X is capable of some process P that has input Y." [] +synonym: "utilizes" BROAD [] property_value: IAO:0000112 "A diagnostic testing device utilizes a specimen." xsd:string -property_value: IAO:0000117 "Asiyah Lin" xsd:string -property_value: IAO:0000117 "Bill Duncan (https://orcid.org/0000-0001-9625-1899)" xsd:string +property_value: IAO:0000117 https://orcid.org/0000-0001-9625-1899 xsd:string +property_value: IAO:0000117 https://orcid.org/0000-0003-2620-0345 xsd:string property_value: IAO:0000232 "A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input." xsd:string property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-relations/issues/497" xsd:string holds_over_chain: capable_of has_input -creation_date: 2021-11-08 +creation_date: 2021-11-08T12:00:00Z + +[Typedef] +id: RO:0040035 +name: disease relationship +def: "This relation groups relations between diseases and any other kind of entity." [] [Typedef] id: RO:0040036 @@ -305102,7 +426188,6 @@ namespace: external namespace: uberon def: "x adjacent to y if and only if x and y share a boundary." [] def: "x adjacent_to y iff: x and y share a boundary" [] -def: "x adjacent_to y iff: x and y share a boundary." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam @@ -305122,10 +426207,10 @@ is_a: RO:0002163 ! spatially disjoint from [Typedef] id: anterior_to +name: anterior to name: anterior_to namespace: uberon def: "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer" [http://orcid.org/0000-0002-6601-2165] -def: "x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer." [http://orcid.org/0000-0002-6601-2165] xref: BSPO:0000096 is_transitive: true created_by: cjm @@ -305137,7 +426222,7 @@ name: anteriorly connected to namespace: uberon def: "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: connected_to ! connected to -is_a: posterior_to ! posterior_to +is_a: posterior_to ! posterior to is_a: transitively_anteriorly_connected_to ! transitively anteriorly connected to [Typedef] @@ -305164,6 +426249,8 @@ namespace: uberon def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." [] xref: RO:0002177 property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string +domain: CARO:0000003 ! connected anatomical structure +range: CARO:0000003 ! connected anatomical structure holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: RO:0002323 ! mereotopologically related to is_a: RO:0002567 ! biomechanically related to @@ -305184,28 +426271,11 @@ property_value: IAO:0000112 "this apple is bearer of this red color" xsd:string property_value: IAO:0000112 "this vase is bearer of this fragility" xsd:string property_value: IAO:0000118 "bearer_of" xsd:string property_value: IAO:0000118 "is bearer of" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 range: BFO:0000020 ! specifically dependent continuant is_inverse_functional: true -[Typedef] -id: boundary_of -name: 2D boundary of -name: boundary of -namespace: uberon -def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" [] -xref: RO:0002000 -property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string -property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string -property_value: IAO:0000112 "the surface of my skin is a 2D boundary of my body" xsd:string -property_value: IAO:0000118 "2D_boundary_of" xsd:string -property_value: IAO:0000118 "boundary of" xsd:string -property_value: IAO:0000118 "is 2D boundary of" xsd:string -property_value: IAO:0000118 "is boundary of" xsd:string -property_value: RO:0001900 RO:0001901 -is_a: RO:0002323 ! mereotopologically related to -inverse_of: has_boundary ! has 2D boundary - [Typedef] id: bounding_layer_of name: bounding layer of @@ -305229,10 +426299,11 @@ def: "x is a branching part of y if and only if x is part of y and x is connecte subset: ro-eco xref: RO:0002380 property_value: editor_note "we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve" xsd:string -property_value: IAO:0000114 IAO:0000428 +property_value: IAO:0000112 "In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is a (direct) branching part of T. B1-1, B1-2, and B1-3 are also branching parts of T, but these are considered indirect branching parts as they do not directly connect to the main stem S" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso FMA:85994 xsd:string property_value: seeAlso FMA:85994 +property_value: seeAlso https://github.com/obophenotype/uberon/issues/2212 is_a: part_of ! part_of is_a: RO:0002375 ! in branching relationship with inverse_of: has_branching_part ! has branching part @@ -305244,6 +426315,7 @@ name: by_means [Typedef] id: capable_of name: capable of +name: capable_of namespace: external namespace: uberon def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] @@ -305380,7 +426452,6 @@ name: composed primarily of namespace: uberon def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." [] def: "x composed_primarily_of y iff: more than half of the mass of x is made from parts of y" [] -def: "x composed_primarily_of y iff: more than half of the mass of x is made from parts of y." [] subset: ro-eco xref: RO:0002473 property_value: IAO:0000112 "'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'" xsd:string @@ -305397,6 +426468,18 @@ name: conduit for namespace: uberon def: "x is a conduit for y iff y passes through the lumen of x." [] +[Typedef] +id: confers_advantage_in +name: confers advantage in +namespace: uberon +subset: ro-eco +xref: RO:0002322 +property_value: editor_note "An experimental relation currently used to connect a feature possessed by an organism (e.g. anatomical structure, biological process, phenotype or quality) to a habitat or environment in which that feature is well suited, adapted or provides a reproductive advantage for the organism. For example, fins to an aquatic environment. Usually this will mean that the structure is adapted for this environment, but we avoid saying this directly - primitive forms of the structure may not have evolved specifically for that environment (for example, early wings were not necessarily adapted for an aerial environment). Note also that this is a statement about the general class of structures - not every instance of a limb need confer an advantage for a terrestrial environment, e.g. if the limb is vestigial." xsd:string +property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000118 "adapted for" xsd:string +range: ENVO:01000254 ! environmental system +is_a: RO:0002321 ! ecologically related to + [Typedef] id: connected_to name: connected to @@ -305480,6 +426563,7 @@ id: dc-contributor name: contributor namespace: uberon xref: http://purl.org/dc/elements/1.1/contributor +xref: http://purl.org/dc/terms/contributor is_metadata_tag: true [Typedef] @@ -305495,6 +426579,7 @@ is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to [Typedef] id: deep_to +name: deep to name: deep_to namespace: uberon def: "Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines." [http://orcid.org/0000-0002-6601-2165] @@ -305503,13 +426588,24 @@ is_transitive: true [Typedef] id: derives_from +name: derives from name: derives_from namespace: protein namespace: sequence +def: "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] subset: SOFA xref: RO:0001000 +property_value: editor_note "This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'." xsd:string +property_value: IAO:0000112 "this cell derives from this parent cell (cell division)" xsd:string +property_value: IAO:0000112 "this nucleus derives from this parent nucleus (nuclear division)" xsd:string +property_value: IAO:0000114 IAO:0000125 +property_value: IAO:0000118 "derives_from" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl +domain: BFO:0000004 ! independent continuant +range: BFO:0000004 ! independent continuant is_transitive: true is_transitive: true +inverse_of: RO:0001001 ! derives into [Typedef] id: developmentally_contributes_to @@ -305543,6 +426639,8 @@ property_value: IAO:0000119 " Developmental Biology, Gilbert, 8th edition, figur property_value: IAO:0000119 GO:0001759 xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 property_value: IAO:0000232 "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" xsd:string +domain: CARO:0000003 ! connected anatomical structure +range: CARO:0000003 ! connected anatomical structure is_a: developmentally_preceded_by ! developmentally preceded by inverse_of: RO:0002257 ! developmentally induces @@ -305551,7 +426649,6 @@ id: developmentally_preceded_by name: developmentally preceded by name: developmentally_preceded_by namespace: plant_ontology -namespace: uberon def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" [] def: "X developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p." [RO:0002258] comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from @@ -305609,7 +426706,6 @@ transitive_over: part_of ! part_of [Typedef] id: develops_from_part_of name: develops from part of -name: develops_from_part_of namespace: uberon def: "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" [] xref: RO:0002225 @@ -305621,15 +426717,14 @@ is_a: develops_from ! develops from [Typedef] id: develops_in name: develops in -name: develops_in namespace: uberon def: "x develops_in y if x is located in y whilst x is developing" [] -comment: This relation take from EHDAA2 - precise semantics yet to be defined xref: RO:0002226 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 "EHDAA2" xsd:string property_value: IAO:0000119 "Jonathan Bard, EHDAA2" xsd:string +domain: CARO:0000000 ! anatomical entity holds_over_chain: directly_develops_from located_in is_a: developmentally_preceded_by ! developmentally preceded by @@ -305647,8 +426742,8 @@ property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: IAO:0000117 "Terry Meehan" xsd:string is_transitive: true is_a: has_potential_to_develop_into ! has potential to develop into -is_a: has_potential_to_directly_develop_into ! has potential to directly develop into is_a: RO:0002286 ! developmentally succeeded by +is_a: RO:0002388 ! has potential to directly develop into [Typedef] id: different_in_magnitude_relative_to @@ -305661,7 +426756,6 @@ range: PATO:0000001 ! quality [Typedef] id: directly_develops_from name: directly develops from -name: directly_develops_from namespace: uberon def: "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y." [] comment: TODO - add child relations from DOS @@ -305675,8 +426769,100 @@ property_value: RO:0002575 RO:0002202 is_a: develops_from ! develops from inverse_of: RO:0002210 ! directly develops into +[Typedef] +id: disease_arises_from_feature +name: disease arises from feature +name: disease has basis in feature +def: "A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature." [] +xref: RO:0004022 +is_a: RO:0002200 ! has phenotype +is_a: RO:0004019 ! disease has basis in + +[Typedef] +id: disease_arises_from_structure +name: disease arises from alteration in structure +name: disease arises from structure +def: "A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles." [] +xref: RO:0004030 +range: CARO:0000003 ! connected anatomical structure +is_a: RO:0004019 ! disease has basis in + +[Typedef] +id: disease_causes_feature +name: disease causes feature + +[Typedef] +id: disease_disrupts +name: disease causes disruption of +name: disease disrupts +def: "A relationship between a disease and a process where the disease process disrupts the execution of the process." [] +xref: RO:0004024 +range: BFO:0000015 ! process +is_a: RO:0004023 ! causal relationship with disease as subject +transitive_over: part_of ! part_of + +[Typedef] +id: disease_has_basis_in_disruption_of +name: disease caused by disruption of +name: disease has basis in disruption of +def: "A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process." [] +comment: Editor note: TODO property chain: disease_has_location <- dhbido o occurs_in +xref: RO:0004021 +range: BFO:0000015 ! process +is_a: disease_disrupts ! disease disrupts +is_a: RO:0004019 ! disease has basis in +transitive_over: part_of ! part_of + +[Typedef] +id: disease_has_basis_in_dysfunction_of +name: disease has basis in dysfunction of +def: "A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function." [] +xref: RO:0004020 +range: CARO:0000006 ! material anatomical entity +is_a: RO:0004019 ! disease has basis in + +[Typedef] +id: disease_has_feature +name: disease has feature +def: "A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease." [] +xref: RO:0004029 +is_a: RO:0040035 ! disease relationship +transitive_over: has_part ! has_part + +[Typedef] +id: disease_has_infectious_agent +name: disease has infectious agent +def: "A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent." [] +xref: RO:0014001 +is_a: RO:0004019 ! disease has basis in + +[Typedef] +id: disease_has_inflammation_site +name: disease has inflammation site +def: "A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity" [] +xref: RO:0004027 +range: BFO:0000004 ! independent continuant +is_a: disease_has_location ! disease has location +transitive_over: part_of ! part_of + +[Typedef] +id: disease_has_location +name: disease has location +def: "A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." [] +xref: RO:0004026 +range: BFO:0000004 ! independent continuant +is_a: RO:0040035 ! disease relationship +transitive_over: part_of ! part_of + +[Typedef] +id: disease_has_major_feature +name: disease has major feature +is_a: disease_has_feature ! disease has feature +transitive_over: has_part ! has_part + [Typedef] id: distal_to +name: distal to name: distal_to namespace: uberon def: "x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal)." [http://orcid.org/0000-0002-6601-2165] @@ -305694,6 +426880,7 @@ inverse_of: proximally_connected_to ! proximally connected to [Typedef] id: distalmost_part_of +name: distalmost part of name: distalmost_part_of namespace: uberon def: "X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y" [https://orcid.org/0000-0002-6601-2165] @@ -305702,6 +426889,7 @@ is_a: in_distal_side_of ! in_distal_side_of [Typedef] id: dorsal_to +name: dorsal to name: dorsal_to namespace: uberon def: "x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." [http://orcid.org/0000-0002-6601-2165] @@ -305727,7 +426915,12 @@ is_a: connected_to ! connected to id: editor_note name: editor note namespace: uberon +def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." [] xref: IAO:0000116 +property_value: IAO:0000111 "editor note" xsd:string +property_value: IAO:0000114 IAO:0000122 +property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string +property_value: IAO:0000119 GROUP:OBI: xsd:string is_metadata_tag: true [Typedef] @@ -305872,6 +427065,7 @@ def: "A grouping relationship for any relationship directly involving a function xref: RO:0002328 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "This is a grouping relation that collects relations used for the purpose of connecting structure and function" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl [Typedef] id: has_boundary @@ -305901,11 +427095,17 @@ subset: RO:0002259 xref: RO:0002569 property_value: IAO:0000117 "Chris Mungall" xsd:string is_transitive: true +is_a: has_part ! has_part is_a: RO:0002375 ! in branching relationship with +[Typedef] +id: has_completed +name: has_completed + [Typedef] id: has_component name: has component +name: has_component namespace: external namespace: uberon def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] @@ -305921,9 +427121,7 @@ is_a: has_part ! has_part [Typedef] id: has_cross_section name: has_cross_section -namespace: quality -def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [PATOC:CJM] -comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. +def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [] [Typedef] id: has_developmental_contribution_from @@ -305988,6 +427186,7 @@ xref: RO:0002233 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "consumes" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl domain: BFO:0000015 ! process range: BFO:0000040 ! material entity holds_over_chain: starts_with has_input @@ -306000,6 +427199,13 @@ name: has_low_plasma_membrane_amount def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617)." [PMID:19243617] is_a: RO:0002104 ! has plasma membrane part +[Typedef] +id: has_material_basis_in_germline_mutation_in +name: has material basis in germline mutation in +xref: RO:0004003 +is_a: RO:0004000 ! condition has genetic basis in +inverse_of: RO:0004013 ! is causal germline mutation in + [Typedef] id: has_member name: has member @@ -306007,38 +427213,51 @@ namespace: uberon def: "has member is a mereological relation between a collection and an item." [] xref: RO:0002351 property_value: IAO:0000119 "SIO" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 is_a: has_part ! has_part +[Typedef] +id: has_modifier +name: has modifier +def: "A relation that holds between an attribute or a qualifier and another attribute." [] +xref: RO:0002573 +domain: BFO:0000020 ! specifically dependent continuant +range: BFO:0000020 ! specifically dependent continuant + +[Typedef] +id: has_muscle_antagonist +name: has muscle antagonist +namespace: uberon +def: "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." [] +xref: RO:0002568 +property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000119 Wikipedia:Antagonist_(muscle) xsd:string +is_a: RO:0002567 ! biomechanically related to + [Typedef] id: has_muscle_insertion name: has muscle insertion -name: has_muscle_insertion namespace: uberon def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." [] -def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." [Wikipedia:Insertion_(anatomy)] -comment: The insertion is the point of attachment of a muscle that moves the most when the muscle shortens, or the most distal end of limb muscles xref: RO:0002373 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 Wikipedia:Insertion_(anatomy) xsd:string -property_value: seeAlso dbpprop:insertion property_value: seeAlso http://dbpedia.org/property/insertion +domain: CARO:0000003 ! connected anatomical structure is_a: attaches_to ! attaches_to is_a: RO:0002567 ! biomechanically related to [Typedef] id: has_muscle_origin name: has muscle origin -name: has_muscle_origin namespace: uberon def: "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." [] -def: "m has_muscle_origin s iff m is attaches_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." [Wikipedia:Insertion_(anatomy)#Muscles] -comment: The origin is the end of a muscle that attaches to the more fixed part of the skeleton, which is the proximal end in limb muscles xref: RO:0002372 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 Wikipedia:Insertion_(anatomy) xsd:string -property_value: seeAlso dbpprop:origin property_value: seeAlso http://dbpedia.org/property/origin +domain: CARO:0000003 ! connected anatomical structure is_a: attaches_to ! attaches_to is_a: RO:0002567 ! biomechanically related to @@ -306054,10 +427273,15 @@ is_a: negatively_regulated_by ! negatively regulated by created_by: dos creation_date: 2017-05-24T09:31:01Z +[Typedef] +id: has_not_completed +name: has_not_completed + [Typedef] id: has_output name: has output namespace: external +def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." [] def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_go_ontology @@ -306067,6 +427291,7 @@ xref: RO:0002234 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "produces" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl holds_over_chain: ends_with has_output is_a: has_participant ! has participant inverse_of: output_of ! output of @@ -306104,6 +427329,7 @@ property_value: IAO:0000112 "my body has part my brain (continuant parthood, two property_value: IAO:0000112 "my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)" xsd:string property_value: IAO:0000112 "this year has part this day (occurrent parthood)" xsd:string property_value: IAO:0000118 "has_part" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 is_cyclic: false is_transitive: true @@ -306124,6 +427350,7 @@ property_value: IAO:0000112 "this blood coagulation has participant this blood c property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string property_value: IAO:0000112 "this process has participant this input material (or this output material)" xsd:string property_value: IAO:0000118 "has_participant" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: has_part has_participant @@ -306133,7 +427360,6 @@ id: has_potential_to_develop_into name: has potential to develop into namespace: uberon def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" [] -def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y." [] xref: RO:0002387 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string @@ -306144,22 +427370,22 @@ id: has_potential_to_developmentally_contribute_to name: has potential to developmentally contribute to namespace: uberon def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" [] -def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y." [] xref: RO:0002385 property_value: IAO:0000114 IAO:0000428 property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: RO:0002384 ! has developmental potential involving [Typedef] -id: has_potential_to_directly_develop_into -name: has potential to directly develop into -namespace: uberon -def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] -def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y." [] -xref: RO:0002388 -property_value: IAO:0000114 IAO:0000428 -property_value: IAO:0000117 "Chris Mungall" xsd:string -is_a: has_potential_to_develop_into ! has potential to develop into +id: has_primary_input +name: has primary input +namespace: external +def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"} +subset: http://purl.obolibrary.org/obo/valid_for_go_ontology +xref: RO:0004009 +is_a: has_input ! has input +is_a: has_primary_input_or_output ! has primary input or output +created_by: cjm +creation_date: 2018-12-13T11:26:56Z [Typedef] id: has_primary_input_or_output @@ -306187,12 +427413,14 @@ creation_date: 2018-12-13T11:26:32Z [Typedef] id: has_quality name: has quality +name: has_quality namespace: uberon def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] xref: RO:0000086 property_value: editor_note "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string property_value: IAO:0000112 "this apple has quality this red color" xsd:string property_value: IAO:0000118 "has_quality" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl range: BFO:0000019 ! quality is_a: bearer_of ! bearer of @@ -306218,11 +427446,13 @@ xref: RO:0000087 property_value: editor_note "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists." xsd:string property_value: IAO:0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)" xsd:string property_value: IAO:0000118 "has_role" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl domain: BFO:0000004 ! independent continuant range: BFO:0000023 ! role is_cyclic: false is_transitive: false is_a: bearer_of ! bearer of +is_a: RO:0002502 ! depends on [Typedef] id: has_skeleton @@ -306237,7 +427467,9 @@ property_value: IAO:0000112 "Forelimb SubClassOf has_skeleton some 'Forelimb ske property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has supporting framework" xsd:string property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string +domain: CARO:0000003 ! connected anatomical structure domain: UBERON:0000475 ! organism subdivision +range: CARO:0000006 ! material anatomical entity range: UBERON:0010912 ! subdivision of skeleton is_a: has_part ! has_part inverse_of: skeleton_of ! skeleton of @@ -306300,7 +427532,7 @@ property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: RO:0002575 RO:0002494 property_value: seeAlso SIO:000658 is_a: develops_from ! develops from -is_a: directly_develops_from ! directly_develops_from +is_a: directly_develops_from ! directly develops from is_a: transformation_of ! transformation of [Typedef] @@ -306328,12 +427560,13 @@ is_a: immediately_precedes ! immediately_precedes [Typedef] id: immediately_deep_to +name: immediately deep to name: immediately_deep_to namespace: uberon def: "This relation holds when both the deep_to and ajdacent_to relationship similarly hold." [http://orcid.org/0000-0002-6601-2165] xref: BSPO:0001107 is_a: adjacent_to ! adjacent_to -is_a: deep_to ! deep_to +is_a: deep_to ! deep to [Typedef] id: immediately_preceded_by @@ -306342,7 +427575,6 @@ name: immediately_preceded_by namespace: external namespace: uberon def: "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)" [] -def: "X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)." [] comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) synonym: "directly preceded by" EXACT [] synonym: "is directly preceded by" EXACT [] @@ -306374,6 +427606,7 @@ is_a: precedes ! precedes [Typedef] id: in_anterior_side_of +name: in anterior side of name: in_anterior_side_of namespace: uberon def: "X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion." [BSPO:PATO_mtg_2009] @@ -306390,25 +427623,23 @@ is_a: part_of ! part_of [Typedef] id: in_lateral_side_of +name: in lateral side of name: in_lateral_side_of namespace: uberon def: "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure" [https://orcid.org/0000-0002-6601-2165] -def: "X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure." [https://orcid.org/0000-0002-6601-2165] xref: BSPO:0000126 property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI is_a: part_of ! part_of [Typedef] id: in_left_side_of -name: in_left_side_of +name: in left side of namespace: uberon -def: "X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion." [BSPO:PATO_mtg_2009] xref: BSPO:0000120 -property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI -is_a: in_lateral_side_of ! in_lateral_side_of [Typedef] id: in_posterior_side_of +name: in posterior side of name: in_posterior_side_of namespace: uberon def: "X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion." [BSPO:PATO_mtg_2009] @@ -306430,12 +427661,9 @@ name: in_response_to [Typedef] id: in_right_side_of -name: in_right_side_of +name: in right side of namespace: uberon -def: "X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion." [BSPO:PATO_mtg_2009] xref: BSPO:0000121 -property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern xsd:anyURI -is_a: in_lateral_side_of ! in_lateral_side_of [Typedef] id: in_taxon @@ -306450,6 +427678,7 @@ property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000117 "Jennifer Deegan" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072 property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947 +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints range: CARO:0001010 ! organism or virus or viroid holds_over_chain: attaches_to in_taxon @@ -306478,9 +427707,7 @@ is_a: RO:0002320 ! evolutionarily related to [Typedef] id: increased_in_magnitude_relative_to name: increased_in_magnitude_relative_to -namespace: quality -def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] -comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. +def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [] domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true @@ -306496,56 +427723,15 @@ holds_over_chain: has_branching_part indirectly_supplies holds_over_chain: has_branching_part supplies is_transitive: true -[Typedef] -id: inheres_in -name: characteristic of -name: inheres in -def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] -def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] -comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. -xref: RO:0000052 -property_value: editor_note "A dependent inheres in its bearer at all times for which the dependent exists." xsd:string -property_value: IAO:0000111 "inheres in" xsd:string -property_value: IAO:0000112 "this fragility inheres in this vase" xsd:string -property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string -property_value: IAO:0000112 "this red color inheres in this apple" xsd:string -property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string -property_value: IAO:0000118 "inheres_in" xsd:string -property_value: RO:0001900 RO:0001901 -is_functional: true -is_a: inheres_in_part_of ! inheres in part of -inverse_of: bearer_of ! bearer of - -[Typedef] -id: inheres_in_part_of -name: characteristic of part of -name: inheres in part of -def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] -def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." [] -xref: RO:0002314 -property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string -property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" xsd:string -property_value: IAO:0000117 "Chris Mungall" xsd:string -property_value: IAO:0000118 "inheres in part of" xsd:string -property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 -property_value: RO:0001900 RO:0001901 -property_value: seeAlso "defining-property-chains-involving-reflexivity" -property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ -holds_over_chain: inheres_in part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} -is_a: RO:0002502 ! depends on -transitive_over: part_of ! part_of - [Typedef] id: innervated_by name: innervated_by namespace: uberon -comment: http://code.google.com/p/obo-relations/issues/detail?id=6 -synonym: "nerve supply" EXACT [FMA:85999] xref: RO:0002005 property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613 xsd:anyURI property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string -property_value: seeAlso dbprop:nerve -property_value: seeAlso FMA:85999 +domain: CARO:0000003 ! connected anatomical structure +range: CARO:0001001 ! neuron projection bundle inverse_of: innervates ! innervates transitive_over: branching_part_of ! branching_part_of @@ -306554,12 +427740,12 @@ id: innervates name: innervates namespace: uberon def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." [] -comment: http://code.google.com/p/obo-relations/issues/detail?id=6 xref: RO:0002134 property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string property_value: RO:0001900 RO:0001901 +domain: CARO:0001001 ! neuron projection bundle transitive_over: part_of ! part_of expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" [] @@ -306575,6 +427761,18 @@ property_value: IAO:0000117 "Chris Mungall" xsd:string is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in +[Typedef] +id: interacts_with +name: interacts_with + +[Typedef] +id: interacts_with_an_exposure_receptor_via +name: interacts_with_an_exposure_receptor_via + +[Typedef] +id: interacts_with_an_exposure_stressor_via +name: interacts_with_an_exposure stressor_via + [Typedef] id: is_about name: is_about @@ -306688,6 +427886,12 @@ domain: BFO:0000141 ! immaterial entity is_a: lumen_of ! lumen of is_a: part_of ! part_of +[Typedef] +id: measured_in_taxon +name: measured_in_taxon +comment: Taxon in which a trait is usually measured. +is_metadata_tag: true + [Typedef] id: member_of name: member of @@ -306702,6 +427906,7 @@ property_value: IAO:0000112 "An organism that is a member of a population of org property_value: IAO:0000118 "is member of" xsd:string property_value: IAO:0000118 "member part of" xsd:string property_value: IAO:0000119 "SIO" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 is_transitive: true is_a: part_of ! part_of @@ -306737,6 +427942,23 @@ is_a: causally_upstream_of,_negative_effect ! causally upstream of, negative eff is_a: regulates ! regulates inverse_of: negatively_regulated_by ! negatively regulated by +[Typedef] +id: negatively_regulates_characteristic +name: negatively regulates characteristic +namespace: gene_ontology +def: "A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C." [] +xref: RO:0019002 +property_value: dc-contributor https://orcid.org/0000-0002-8688-6599 +holds_over_chain: negatively_regulates positively_regulates_characteristic +holds_over_chain: positively_regulates negatively_regulates_characteristic +is_a: regulates_characteristic ! regulates characteristic + +[Typedef] +id: not_measured_in_taxon +name: not_measured_in_taxon +comment: Taxon in which a measurement is usually not taken. +is_metadata_tag: true + [Typedef] id: occurs_in name: occurs in @@ -306764,7 +427986,6 @@ name: only in taxon name: only_in_taxon namespace: plant_ontology namespace: uberon -def: "S only_in_taxon T iff: S SubClassOf in_taxon only T." [PMID:20973947] def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] xref: RO:0002160 property_value: editor_note "The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g.\n\n 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria" xsd:string @@ -306788,6 +428009,7 @@ subset: ro-eco subset: RO:0002259 xref: RO:0002353 property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl is_transitive: false is_a: functionally_related_to ! functionally related to is_a: participates_in ! participates in @@ -306798,23 +428020,26 @@ name: overlaps namespace: external namespace: sequence namespace: uberon +def: "A overlaps B if they share some part in common." [] def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] def: "X overlaps Y iff there exists some Z such that Z contained_by X and Z contained_by Y." [PMID:20226267] +def: "x overlaps y iff they have some part in common." [] comment: Example: coding_exon overlaps CDS. subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension subset: http://purl.obolibrary.org/obo/valid_for_gocam subset: ro-eco xref: RO:0002131 property_value: IAO:0000114 IAO:0000125 +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 holds_over_chain: has_part overlaps holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} holds_over_chain: part_of part_of +is_symmetric: true is_a: RO:0002323 ! mereotopologically related to transitive_over: part_of ! part_of created_by: kareneilbeck creation_date: 2010-10-14T01:33:15Z -expand_expression_to: "BFO_0000051 some (BFO_0000050 some ?Y)" [] expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)" [] [Typedef] @@ -306826,8 +428051,10 @@ namespace: plant_ontology namespace: protein namespace: quality namespace: sequence +namespace: spatial namespace: uberon def: "a core relation that holds between a part and its whole" [] +def: "For continuants: C part_of C' if and only if: given any c that instantiates C at a time t, there is some c' such that c' instantiates C' at time t, and c *part_of* c' at t. For processes: P part_of P' if and only if: given any p that instantiates P at a time t, there is some p' such that p' instantiates P' at time t, and p *part_of* p' at t. (Here *part_of* is the instance-level part-relation.)" [] def: "X part_of Y if X is a subregion of Y." [http://precedings.nature.com/documents/3495/version/1] comment: Example: amino_acid part_of polypeptide. subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension @@ -306841,7 +428068,6 @@ property_value: editor_note "Everything is part of itself. Any part of any part property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string -property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: IAO:0000111 "is part of" xsd:string @@ -306854,6 +428080,8 @@ property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" property_value: IAO:0000112 "this day is part of this year (occurrent parthood)" xsd:string property_value: IAO:0000118 "part_of" xsd:string property_value: IAO:0000118 "part_of" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl property_value: RO:0001900 RO:0001901 property_value: RO:0040042 BFO:0000002 property_value: RO:0040042 BFO:0000003 @@ -306870,17 +428098,6 @@ is_transitive: true is_a: overlaps ! overlaps inverse_of: has_part ! has_part -[Typedef] -id: part_of_structure_that_is_capable_of -name: part of structure that is capable of -namespace: uberon -def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] -xref: RO:0002329 -property_value: IAO:0000117 "Chris Mungall" xsd:string -property_value: IAO:0000118 "false" xsd:boolean -holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"} -is_a: functionally_related_to ! functionally related to - [Typedef] id: participates_in name: participates in @@ -306895,6 +428112,7 @@ property_value: IAO:0000112 "this blood clot participates in this blood coagulat property_value: IAO:0000112 "this input material (or this output material) participates in this process" xsd:string property_value: IAO:0000112 "this investigator participates in this investigation" xsd:string property_value: IAO:0000118 "participates_in" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl domain: BFO:0000002 ! continuant range: BFO:0000003 ! occurrent inverse_of: has_participant ! has participant @@ -306930,8 +428148,19 @@ is_a: causally_upstream_of,_positive_effect ! causally upstream of, positive eff is_a: regulates ! regulates inverse_of: positively_regulated_by ! positively regulated by +[Typedef] +id: positively_regulates_characteristic +name: positively regulates characteristic +namespace: gene_ontology +def: "A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C." [] +xref: RO:0019001 +property_value: dc-contributor https://orcid.org/0000-0002-8688-6599 +holds_over_chain: positively_regulates positively_regulates_characteristic +is_a: regulates_characteristic ! regulates characteristic + [Typedef] id: posterior_to +name: posterior to name: posterior_to namespace: uberon def: "x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail." [http://orcid.org/0000-0002-6601-2165] @@ -306957,7 +428186,6 @@ namespace: uberon def: "The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P." [POC:Laurel_Cooper] def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] def: "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)" [] -def: "X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)." [] comment: Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. subset: ro-eco synonym: "is preceded by" EXACT [SIO:000249] @@ -306995,6 +428223,10 @@ is_a: RO:0002222 ! temporally related to created_by: Laurel_Cooper creation_date: 2015-06-04T17:18:40Z +[Typedef] +id: predisposes_towards +name: predisposes towards + [Typedef] id: process_has_causal_agent name: process has causal agent @@ -307015,6 +428247,7 @@ subset: ro-eco xref: RO:0003001 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Melissa Haendel" xsd:string +property_value: IAO:0000412 http://purl.obolibrary.org/obo/ro.owl domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity @@ -307040,6 +428273,7 @@ namespace: uberon [Typedef] id: proximal_to +name: proximal to name: proximal_to namespace: uberon def: "x proximal_to y iff x is closer to the point of attachment with the body than y." [http://orcid.org/0000-0002-6601-2165] @@ -307056,13 +428290,41 @@ is_a: transitively_proximally_connected_to ! transitively proximally connected t [Typedef] id: proximalmost_part_of +name: proximalmost part of name: proximalmost_part_of namespace: uberon def: "X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y" [https://orcid.org/0000-0002-6601-2165] -def: "X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y." [https://orcid.org/0000-0002-6601-2165] xref: BSPO:0001106 is_a: in_proximal_side_of ! in_proximal_side_of +[Typedef] +id: realized_in +name: realized in +xref: BFO:0000054 +domain: BFO:0000017 ! realizable entity +range: BFO:0000015 ! process +inverse_of: BFO:0000055 ! realizes + +[Typedef] +id: realized_in_response_to +name: realized in response to +def: "r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r." [] +synonym: "triggered by process" EXACT [] +xref: RO:0009501 +domain: BFO:0000017 ! realizable entity +range: BFO:0000015 ! process +is_a: RO:0002410 ! causally related to + +[Typedef] +id: realized_in_response_to_stimulus +name: realized in response to stimulus +def: "A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M." [] +xref: RO:0004028 +domain: BFO:0000017 ! realizable entity +range: BFO:0000040 ! material entity +holds_over_chain: realized_in_response_to has_input +is_a: RO:0002410 ! causally related to + [Typedef] id: reciprocal_of name: reciprocal_of @@ -307087,6 +428349,7 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within [Typedef] id: regulates name: regulates +name: regulates (processual) namespace: external def: "process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2." [] subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension @@ -307113,6 +428376,18 @@ is_a: causally_upstream_of ! causally upstream of inverse_of: regulated_by ! regulated by transitive_over: RO:0002025 ! has effector activity +[Typedef] +id: regulates_characteristic +name: regulates characteristic +namespace: gene_ontology +def: "A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C." [] +xref: RO:0019000 +property_value: dc-contributor https://orcid.org/0000-0002-8688-6599 +domain: BFO:0000015 ! process +range: PATO:0000001 ! quality +holds_over_chain: regulates regulates_characteristic +is_a: RO:0002410 ! causally related to + [Typedef] id: regulates_levels_of name: regulates levels of @@ -307181,6 +428456,7 @@ property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso Ontology:extensions domain: GO:0008150 ! biological_process +range: CARO:0000003 ! connected anatomical structure is_a: RO:0002324 ! developmentally related to [Typedef] @@ -307300,6 +428576,17 @@ xref: RO:0002592 is_a: has_participant ! has participant is_a: RO:0040036 ! results in changes to anatomical or cellular structure +[Typedef] +id: results_in_transport_across +name: results in transport across +namespace: external +def: "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." [] +subset: http://purl.obolibrary.org/obo/valid_for_go_ontology +xref: RO:0002342 +property_value: IAO:0000117 "Chris Mungall" xsd:string +is_a: results_in_transport_to_from_or_in ! results in transport to from or in +is_a: RO:0002021 ! occurs across + [Typedef] id: results_in_transport_along name: results in transport along @@ -307321,13 +428608,9 @@ is_a: RO:0002337 ! related via localization to [Typedef] id: simultaneous_with name: simultaneous with -name: simultaneous_with namespace: uberon -def: "Relation between occurrents, shares start and end boundaries." [Allen:is_equal_to, https://orcid.org/0000-0002-6601-2165] comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2) subset: ro-eco -synonym: "coincides_with" EXACT [] -synonym: "is_equal_to" EXACT [] xref: RO:0002082 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_transitive: true @@ -307350,6 +428633,8 @@ def: "inverse of has skeleton" [] subset: RO:0002259 xref: RO:0002576 property_value: IAO:0000117 "Chris Mungall" xsd:string +domain: CARO:0000003 ! connected anatomical structure +range: CARO:0000003 ! connected anatomical structure is_a: part_of ! part_of [Typedef] @@ -307391,6 +428676,7 @@ comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B [Typedef] id: superficial_to +name: superficial to name: superficial_to namespace: uberon def: "Near the outer surface of the organism. Thus, skin is superficial to the muscle layer." [http://orcid.org/0000-0002-6601-2165] @@ -307401,13 +428687,9 @@ id: supplies name: supplies namespace: uberon def: "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." [] -def: "relation between an artery and the structure is supplies with blood." [] -comment: source: FMA -synonym: "arterial supply of" EXACT [FMA:86003] xref: RO:0002178 property_value: editor_note "Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 -property_value: seeAlso FMA:86003 domain: UBERON:0001637 ! artery is_a: connected_to ! connected to @@ -307418,7 +428700,6 @@ name: surrounded_by namespace: uberon def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" [] def: "x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y" [https://orcid.org/0000-0002-6601-2165] -def: "x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y." [https://orcid.org/0000-0002-6601-2165] xref: RO:0002219 property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string @@ -307432,7 +428713,6 @@ name: surrounds namespace: uberon def: "inverse of surrounded by" [] def: "inverse of surrounded_by" [https://orcid.org/0000-0002-6601-2165] -def: "inverse of surrounded_by." [https://orcid.org/0000-0002-6601-2165] subset: RO:0002259 xref: RO:0002221 property_value: IAO:0000114 IAO:0000125 @@ -307485,20 +428765,6 @@ namespace: uberon def: "." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_transitive: true -[Typedef] -id: transports_or_maintains_localization_of -name: transports or maintains localization of -namespace: external -def: "Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c." [] -subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension -subset: http://purl.obolibrary.org/obo/valid_for_go_ontology -subset: http://purl.obolibrary.org/obo/valid_for_gocam -xref: RO:0002313 -property_value: IAO:0000117 "Chris Mungall" xsd:string -property_value: IAO:0000118 "regulates localization of" xsd:string -is_a: RO:0002337 ! related via localization to -is_a: RO:0040036 ! results in changes to anatomical or cellular structure - [Typedef] id: tributary_of name: tributary of @@ -307520,10 +428786,12 @@ property_value: IAO:0000119 http://www.medindia.net/glossary/venous_tributary.ht property_value: IAO:0000232 "This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries)" xsd:anyURI property_value: seeAlso http://dbpedia.org/ontology/drainsTo property_value: seeAlso http://en.wikipedia.org/wiki/Tributary xsd:anyURI +is_a: connected_to ! connected to is_a: RO:0002375 ! in branching relationship with [Typedef] id: ventral_to +name: ventral to name: ventral_to namespace: uberon def: "x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly)." [http://orcid.org/0000-0002-6601-2165] diff --git a/patterns/definitions.owl b/patterns/definitions.owl index 1586fb54..a364fb4f 100644 --- a/patterns/definitions.owl +++ b/patterns/definitions.owl @@ -7,10 +7,21 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2022-01-19"^^xsd:string) - + +Annotation(owl:versionInfo "2022-08-03"^^xsd:string) + +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -18,12 +29,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -31,11 +44,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -49,10 +65,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -61,6 +80,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -87,66 +107,186 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -447,7 +587,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -462,6 +601,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -716,7 +856,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1039,6 +1178,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1161,6 +1301,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1189,7 +1330,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1198,6 +1338,43 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6220,7 +6397,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6466,6 +6642,187 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -8812,6 +9169,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -10729,6 +11087,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -11277,7 +11636,9 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) @@ -11373,10 +11734,10 @@ EquivalentClasses( ObjectIntersectio # Class: (body fluid levels) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/attribute_location"^^xsd:string) "The volume when measured in multicellular organism."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/attribute_location"^^xsd:string) "multicellular organism volume"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The volume of a bodily fluid."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "volume of bodily fluid"^^xsd:string) AnnotationAssertion(rdfs:label "body fluid levels"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (calcium ion concentration) @@ -11478,8 +11839,8 @@ EquivalentClasses( ObjectIntersectio # Class: (follicle cell microvillus length) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The microvillus length of a ovarian follicle cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "microvillus length of ovarian follicle cell"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The microvillus length of a follicle cell of egg chamber."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "microvillus length of follicle cell of egg chamber"^^xsd:string) AnnotationAssertion(rdfs:label "follicle cell microvillus length"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -24825,11 +25186,11 @@ AnnotationAssertion(Annotation( "external ear spatial pattern"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (pericyte cell morphology) +# Class: (pericyte morphology) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a pericyte cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of pericyte cell"^^xsd:string) -AnnotationAssertion(rdfs:label "pericyte cell morphology"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a pericyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of pericyte"^^xsd:string) +AnnotationAssertion(rdfs:label "pericyte morphology"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (photoreceptor layer of retina deviation (from_normal)) @@ -27625,12 +27986,12 @@ AnnotationAssertion(Annotation( "stomach acidity"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (cell aging onset quality) +# Class: (cellular senescence onset quality) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The onset quality of a cell aging."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "onset quality of cell aging"^^xsd:string) -AnnotationAssertion(rdfs:label "cell aging onset quality"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The onset quality of a cellular senescence."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "onset quality of cellular senescence"^^xsd:string) +AnnotationAssertion(rdfs:label "cellular senescence onset quality"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (female inguinal canal morphology) @@ -27891,11 +28252,11 @@ AnnotationAssertion(Annotation( "Peyer's patch amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (glomerular visceral epithelial cell amount) +# Class: (podocyte amount) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The amount of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "amount of glomerular visceral epithelial cell"^^xsd:string) -AnnotationAssertion(rdfs:label "glomerular visceral epithelial cell amount"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The amount of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "amount of podocyte"^^xsd:string) +AnnotationAssertion(rdfs:label "podocyte amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (podocyte foot amount) @@ -35899,11 +36260,11 @@ AnnotationAssertion(Annotation( "ureter amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (visceral layer of glomerular capsule morphology) +# Class: (glomerular visceral epithelium morphology) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a visceral layer of glomerular capsule."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of visceral layer of glomerular capsule"^^xsd:string) -AnnotationAssertion(rdfs:label "visceral layer of glomerular capsule morphology"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a glomerular visceral epithelium."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of glomerular visceral epithelium"^^xsd:string) +AnnotationAssertion(rdfs:label "glomerular visceral epithelium morphology"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glomerular parietal epithelium morphology) @@ -36347,12 +36708,12 @@ AnnotationAssertion(Annotation( "neuron displaced"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (obsolete neuron of cerebral cortex displaced) +# Class: (cerebral cortex neuron displaced) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The displaced of a obsolete neuron of cerebral cortex."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "displaced of obsolete neuron of cerebral cortex"^^xsd:string) -AnnotationAssertion(rdfs:label "obsolete neuron of cerebral cortex displaced"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The displaced of a cerebral cortex neuron."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "displaced of cerebral cortex neuron"^^xsd:string) +AnnotationAssertion(rdfs:label "cerebral cortex neuron displaced"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (Cajal-Retzius cell displaced) @@ -42934,11 +43295,11 @@ AnnotationAssertion(Annotation( "inferior alveolar nerve quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (chromosome breakage quality) +# Class: (programmed DNA elimination by chromosome breakage quality) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a chromosome breakage."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of chromosome breakage"^^xsd:string) -AnnotationAssertion(rdfs:label "chromosome breakage quality"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a programmed DNA elimination by chromosome breakage."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of programmed DNA elimination by chromosome breakage"^^xsd:string) +AnnotationAssertion(rdfs:label "programmed DNA elimination by chromosome breakage quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (proximal phalanx of pedal digit 3 quality) @@ -45664,13 +46025,6 @@ AnnotationAssertion(Annotation( "nephron morphogenesis quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (subarachnoid space development quality) - -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a subarachnoid space development."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of subarachnoid space development"^^xsd:string) -AnnotationAssertion(rdfs:label "subarachnoid space development quality"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (neuron fate specification quality) AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a neuron fate specification."^^xsd:string) @@ -45867,11 +46221,11 @@ AnnotationAssertion(Annotation( "skeletal system development quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (glomerular visceral epithelial cell quality) +# Class: (podocyte quality) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of glomerular visceral epithelial cell"^^xsd:string) -AnnotationAssertion(rdfs:label "glomerular visceral epithelial cell quality"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of podocyte"^^xsd:string) +AnnotationAssertion(rdfs:label "podocyte quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (avoidance learning behavior quality) @@ -46819,11 +47173,11 @@ AnnotationAssertion(Annotation( "oxygen atom amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (vitamin (role) amount) +# Class: (vitamin amount) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/chemical_role_attribute"^^xsd:string) "The amount of vitamin (role)."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/chemical_role_attribute"^^xsd:string) "amount of vitamin (role)"^^xsd:string) -AnnotationAssertion(rdfs:label "vitamin (role) amount"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/chemical_role_attribute"^^xsd:string) "The amount of vitamin."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/chemical_role_attribute"^^xsd:string) "amount of vitamin"^^xsd:string) +AnnotationAssertion(rdfs:label "vitamin amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) # Class: (thyroid stimulating hormone amount) @@ -47036,11 +47390,11 @@ AnnotationAssertion(Annotation( "neopterin amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (tumor necrosis factor amount) +# Class: (tumor necrosis factor alpha amount) AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The amount of a tumor necrosis factor."^^xsd:string) AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "amount of tumor necrosis factor"^^xsd:string) -AnnotationAssertion(rdfs:label "tumor necrosis factor amount"^^xsd:string) +AnnotationAssertion(rdfs:label "tumor necrosis factor alpha amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (sphingomyelin amount) @@ -47386,6 +47740,1599 @@ AnnotationAssertion(Annotation( "egg shell color"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (age of onset of Alzheimer disease) + +AnnotationAssertion( "The age at which Alzheimer disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age Alzheimer disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of Alzheimer disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of Alzheimer disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of asthma) + +AnnotationAssertion( "The age at which asthma manifestations first appear."^^xsd:string) +AnnotationAssertion( "age asthma symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of asthma"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of asthma"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of urinary bladder carcinoma) + +AnnotationAssertion( "The age at which urinary bladder carcinoma manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of urinary bladder carcinoma"^^xsd:string) +AnnotationAssertion( "age urinary bladder carcinoma symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of urinary bladder carcinoma"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of cataract) + +AnnotationAssertion( "The age at which cataract manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of cataract"^^xsd:string) +AnnotationAssertion( "age cataract symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of cataract"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of hyperlipidemia) + +AnnotationAssertion( "The age at which hyperlipidemia manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of hyperlipidemia"^^xsd:string) +AnnotationAssertion( "age hyperlipidemia symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of hyperlipidemia"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of osteoarthritis) + +AnnotationAssertion( "The age at which osteoarthritis manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of osteoarthritis"^^xsd:string) +AnnotationAssertion( "age osteoarthritis symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of osteoarthritis"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of Parkinson disease) + +AnnotationAssertion( "The age at which Parkinson disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age Parkinson disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of Parkinson disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of Parkinson disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of essential hypertension) + +AnnotationAssertion( "The age at which essential hypertension manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of essential hypertension"^^xsd:string) +AnnotationAssertion( "age essential hypertension symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of essential hypertension"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of schizophrenia) + +AnnotationAssertion( "The age at which schizophrenia manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of schizophrenia"^^xsd:string) +AnnotationAssertion( "age schizophrenia symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of schizophrenia"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of type 1 diabetes mellitus) + +AnnotationAssertion( "The age at which type 1 diabetes mellitus manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of type 1 diabetes mellitus"^^xsd:string) +AnnotationAssertion( "age type 1 diabetes mellitus symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of type 1 diabetes mellitus"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of type 2 diabetes mellitus) + +AnnotationAssertion( "The age at which type 2 diabetes mellitus manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of type 2 diabetes mellitus"^^xsd:string) +AnnotationAssertion( "age type 2 diabetes mellitus symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of type 2 diabetes mellitus"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of childhood onset asthma) + +AnnotationAssertion( "The age at which childhood onset asthma manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of childhood onset asthma"^^xsd:string) +AnnotationAssertion( "age childhood onset asthma symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of childhood onset asthma"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of alcohol dependence) + +AnnotationAssertion( "The age at which alcohol dependence manifestations first appear."^^xsd:string) +AnnotationAssertion( "age alcohol dependence symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of alcohol dependence"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of alcohol dependence"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of allergic disease) + +AnnotationAssertion( "The age at which allergic disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age allergic disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of allergic disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of allergic disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of amyotrophic lateral sclerosis) + +AnnotationAssertion( "The age at which amyotrophic lateral sclerosis manifestations first appear."^^xsd:string) +AnnotationAssertion( "age amyotrophic lateral sclerosis symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of amyotrophic lateral sclerosis"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of amyotrophic lateral sclerosis"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of bipolar disorder) + +AnnotationAssertion( "The age at which bipolar disorder manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of bipolar disorder"^^xsd:string) +AnnotationAssertion( "age bipolar disorder symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of bipolar disorder"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of Buruli ulcer disease) + +AnnotationAssertion( "The age at which Buruli ulcer disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age Buruli ulcer disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of Buruli ulcer disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of Buruli ulcer disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of frontotemporal dementia) + +AnnotationAssertion( "The age at which frontotemporal dementia manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of frontotemporal dementia"^^xsd:string) +AnnotationAssertion( "age frontotemporal dementia symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of frontotemporal dementia"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of Huntington disease) + +AnnotationAssertion( "The age at which Huntington disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age Huntington disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of Huntington disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of Huntington disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of migraine disorder) + +AnnotationAssertion( "The age at which migraine disorder manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of migraine disorder"^^xsd:string) +AnnotationAssertion( "age migraine disorder symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of migraine disorder"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of migraine with aura) + +AnnotationAssertion( "The age at which migraine with aura manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of migraine with aura"^^xsd:string) +AnnotationAssertion( "age migraine with aura symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of migraine with aura"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of migraine without aura) + +AnnotationAssertion( "The age at which migraine without aura manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of migraine without aura"^^xsd:string) +AnnotationAssertion( "age migraine without aura symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of migraine without aura"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of multiple sclerosis) + +AnnotationAssertion( "The age at which multiple sclerosis manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of multiple sclerosis"^^xsd:string) +AnnotationAssertion( "age multiple sclerosis symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of multiple sclerosis"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of myopia) + +AnnotationAssertion( "The age at which myopia manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of myopia"^^xsd:string) +AnnotationAssertion( "age myopia symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of myopia"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of refractive error) + +AnnotationAssertion( "The age at which refractive error manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of refractive error"^^xsd:string) +AnnotationAssertion( "age refractive error symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of refractive error"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of narcolepsy-cataplexy syndrome) + +AnnotationAssertion( "The age at which narcolepsy-cataplexy syndrome manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of narcolepsy-cataplexy syndrome"^^xsd:string) +AnnotationAssertion( "age narcolepsy-cataplexy syndrome symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of narcolepsy-cataplexy syndrome"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of coronary atherosclerosis) + +AnnotationAssertion( "The age at which coronary atherosclerosis manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of coronary atherosclerosis"^^xsd:string) +AnnotationAssertion( "age coronary atherosclerosis symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of coronary atherosclerosis"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (trait in response to warfarin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with warfarin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to warfarin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to warfarin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to zileuton) + +AnnotationAssertion( "A trait that affects the response to a stimulus with zileuton."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to zileuton trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to zileuton"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to ziprasidone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with ziprasidone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to ziprasidone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to ziprasidone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to zonisamide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with zonisamide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to zonisamide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to zonisamide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to erlotinib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with erlotinib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to erlotinib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to erlotinib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to efavirenz) + +AnnotationAssertion( "A trait that affects the response to a stimulus with efavirenz."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to efavirenz trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to efavirenz"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to radiosensitizing agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with radiosensitizing agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to radiosensitizing agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to radiosensitizing agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to tafenoquine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tafenoquine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tafenoquine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tafenoquine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to migalastat) + +AnnotationAssertion( "A trait that affects the response to a stimulus with migalastat."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to migalastat trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to migalastat"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to endocrine disruptor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with endocrine disruptor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to endocrine disruptor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to endocrine disruptor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to acetylsalicylic acid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with acetylsalicylic acid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to acetylsalicylic acid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to acetylsalicylic acid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to mycophenolic acid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with mycophenolic acid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to mycophenolic acid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to mycophenolic acid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to morphine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with morphine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to morphine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to morphine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to gemcitabine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with gemcitabine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to gemcitabine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to gemcitabine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to vitamin B3) + +AnnotationAssertion( "A trait that affects the response to a stimulus with vitamin B3."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to vitamin B3 trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to vitamin B3"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to bleomycin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with bleomycin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to bleomycin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to bleomycin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to drug) + +AnnotationAssertion( "A trait that affects the response to a stimulus with drug."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to drug trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to drug"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to glucocorticoid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with glucocorticoid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to glucocorticoid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to glucocorticoid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to isoquinoline alkaloid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with isoquinoline alkaloid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to isoquinoline alkaloid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to isoquinoline alkaloid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to camptothecin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with camptothecin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to camptothecin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to camptothecin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to cisplatin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with cisplatin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to cisplatin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to cisplatin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to vancomycin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with vancomycin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to vancomycin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to vancomycin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to rifampicin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with rifampicin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to rifampicin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to rifampicin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to heparin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with heparin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to heparin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to heparin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to vincristine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with vincristine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to vincristine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to vincristine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to cytarabine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with cytarabine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to cytarabine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to cytarabine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to doxorubicin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with doxorubicin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to doxorubicin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to doxorubicin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to serotonin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with serotonin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to serotonin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to serotonin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to melphalan) + +AnnotationAssertion( "A trait that affects the response to a stimulus with melphalan."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to melphalan trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to melphalan"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to silicon dioxide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with silicon dioxide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to silicon dioxide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to silicon dioxide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to ethanol) + +AnnotationAssertion( "A trait that affects the response to a stimulus with ethanol."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to ethanol trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to ethanol"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to aripiprazole) + +AnnotationAssertion( "A trait that affects the response to a stimulus with aripiprazole."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to aripiprazole trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to aripiprazole"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to carboplatin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with carboplatin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to carboplatin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to carboplatin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to bupropion) + +AnnotationAssertion( "A trait that affects the response to a stimulus with bupropion."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to bupropion trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to bupropion"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to buspirone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with buspirone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to buspirone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to buspirone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to vitamin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with vitamin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to vitamin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to vitamin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to antimicrobial agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antimicrobial agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antimicrobial agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antimicrobial agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to platinum) + +AnnotationAssertion( "A trait that affects the response to a stimulus with platinum."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to platinum trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to platinum"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to candesartan) + +AnnotationAssertion( "A trait that affects the response to a stimulus with candesartan."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to candesartan trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to candesartan"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to carbamazepine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with carbamazepine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to carbamazepine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to carbamazepine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to antimetabolite) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antimetabolite."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antimetabolite trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antimetabolite"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to fatty acid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with fatty acid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to fatty acid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to fatty acid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to antidepressant) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antidepressant."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antidepressant trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antidepressant"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to non-steroidal anti-inflammatory drug) + +AnnotationAssertion( "A trait that affects the response to a stimulus with non-steroidal anti-inflammatory drug."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to non-steroidal anti-inflammatory drug trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to non-steroidal anti-inflammatory drug"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to antipsychotic agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antipsychotic agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antipsychotic agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antipsychotic agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to diuretic) + +AnnotationAssertion( "A trait that affects the response to a stimulus with diuretic."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to diuretic trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to diuretic"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to bronchodilator agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with bronchodilator agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to bronchodilator agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to bronchodilator agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to beta-adrenergic antagonist) + +AnnotationAssertion( "A trait that affects the response to a stimulus with beta-adrenergic antagonist."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to beta-adrenergic antagonist trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to beta-adrenergic antagonist"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to antineoplastic agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antineoplastic agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antineoplastic agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antineoplastic agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to anticonvulsant) + +AnnotationAssertion( "A trait that affects the response to a stimulus with anticonvulsant."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to anticonvulsant trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to anticonvulsant"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to thiopurine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with thiopurine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to thiopurine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to thiopurine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to immunosuppressive agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with immunosuppressive agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to immunosuppressive agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to immunosuppressive agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to antiviral drug) + +AnnotationAssertion( "A trait that affects the response to a stimulus with antiviral drug."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to antiviral drug trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to antiviral drug"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to taxane) + +AnnotationAssertion( "A trait that affects the response to a stimulus with taxane."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to taxane trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to taxane"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to escitalopram) + +AnnotationAssertion( "A trait that affects the response to a stimulus with escitalopram."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to escitalopram trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to escitalopram"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to duloxetine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with duloxetine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to duloxetine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to duloxetine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to citalopram) + +AnnotationAssertion( "A trait that affects the response to a stimulus with citalopram."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to citalopram trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to citalopram"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to clozapine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with clozapine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to clozapine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to clozapine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to protease inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with protease inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to protease inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to protease inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to EC 3.1.1.8 (cholinesterase) inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with EC 3.1.1.8 (cholinesterase) inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to EC 3.1.1.8 (cholinesterase) inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to EC 3.1.1.8 (cholinesterase) inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to growth hormone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with growth hormone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to growth hormone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to growth hormone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to clopidogrel) + +AnnotationAssertion( "A trait that affects the response to a stimulus with clopidogrel."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to clopidogrel trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to clopidogrel"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to calcium channel blocker) + +AnnotationAssertion( "A trait that affects the response to a stimulus with calcium channel blocker."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to calcium channel blocker trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to calcium channel blocker"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to tyrosine kinase inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tyrosine kinase inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tyrosine kinase inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tyrosine kinase inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to atorvastatin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with atorvastatin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to atorvastatin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to atorvastatin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to cyclophosphamide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with cyclophosphamide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to cyclophosphamide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to cyclophosphamide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to allopurinol) + +AnnotationAssertion( "A trait that affects the response to a stimulus with allopurinol."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to allopurinol trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to allopurinol"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to cyclosporin A) + +AnnotationAssertion( "A trait that affects the response to a stimulus with cyclosporin A."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to cyclosporin A trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to cyclosporin A"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to tamoxifen) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tamoxifen."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tamoxifen trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tamoxifen"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to dexamethasone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with dexamethasone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to dexamethasone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to dexamethasone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to abacavir) + +AnnotationAssertion( "A trait that affects the response to a stimulus with abacavir."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to abacavir trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to abacavir"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to methotrexate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with methotrexate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to methotrexate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to methotrexate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to paclitaxel) + +AnnotationAssertion( "A trait that affects the response to a stimulus with paclitaxel."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to paclitaxel trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to paclitaxel"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to 5-fluorouracil) + +AnnotationAssertion( "A trait that affects the response to a stimulus with 5-fluorouracil."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to 5-fluorouracil trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 5-fluorouracil"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to diclofenac) + +AnnotationAssertion( "A trait that affects the response to a stimulus with diclofenac."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to diclofenac trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to diclofenac"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to etoposide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with etoposide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to etoposide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to etoposide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to lapatinib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with lapatinib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to lapatinib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to lapatinib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to gefitinib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with gefitinib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to gefitinib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to gefitinib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to lithium(1+)) + +AnnotationAssertion( "A trait that affects the response to a stimulus with lithium(1+)."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to lithium(1+) trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to lithium(1+)"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to fenofibrate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with fenofibrate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to fenofibrate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to fenofibrate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to anticoagulant) + +AnnotationAssertion( "A trait that affects the response to a stimulus with anticoagulant."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to anticoagulant trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to anticoagulant"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to thiazide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with thiazide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to thiazide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to thiazide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to platelet aggregation inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with platelet aggregation inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to platelet aggregation inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to platelet aggregation inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to mercaptopurine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with mercaptopurine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to mercaptopurine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to mercaptopurine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to montelukast) + +AnnotationAssertion( "A trait that affects the response to a stimulus with montelukast."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to montelukast trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to montelukast"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to EC 1.14.14.14 (aromatase) inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with EC 1.14.14.14 (aromatase) inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to EC 1.14.14.14 (aromatase) inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to EC 1.14.14.14 (aromatase) inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to corticosteroid) + +AnnotationAssertion( "A trait that affects the response to a stimulus with corticosteroid."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to corticosteroid trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to corticosteroid"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to tetracyclic antidepressant) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tetracyclic antidepressant."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tetracyclic antidepressant trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tetracyclic antidepressant"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to serotonin uptake inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with serotonin uptake inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to serotonin uptake inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to serotonin uptake inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to bortezomib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with bortezomib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to bortezomib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to bortezomib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to haloperidol) + +AnnotationAssertion( "A trait that affects the response to a stimulus with haloperidol."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to haloperidol trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to haloperidol"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to hydrochlorothiazide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with hydrochlorothiazide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to hydrochlorothiazide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to hydrochlorothiazide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to opioid agent) + +AnnotationAssertion( "A trait that affects the response to a stimulus with opioid agent."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to opioid agent trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to opioid agent"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to floxuridine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with floxuridine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to floxuridine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to floxuridine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to angiotensin receptor antagonist) + +AnnotationAssertion( "A trait that affects the response to a stimulus with angiotensin receptor antagonist."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to angiotensin receptor antagonist trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to angiotensin receptor antagonist"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to tacrolimus hydrate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tacrolimus hydrate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tacrolimus hydrate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tacrolimus hydrate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to metamizole) + +AnnotationAssertion( "A trait that affects the response to a stimulus with metamizole."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to metamizole trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to metamizole"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to ribavirin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with ribavirin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to ribavirin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to ribavirin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to stavudine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with stavudine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to stavudine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to stavudine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to sotalol) + +AnnotationAssertion( "A trait that affects the response to a stimulus with sotalol."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to sotalol trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to sotalol"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to tenofovir (anhydrous)) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tenofovir (anhydrous)."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tenofovir (anhydrous) trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tenofovir (anhydrous)"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to lamotrigine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with lamotrigine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to lamotrigine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to lamotrigine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to amisulpride) + +AnnotationAssertion( "A trait that affects the response to a stimulus with amisulpride."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to amisulpride trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to amisulpride"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to ximelagatran) + +AnnotationAssertion( "A trait that affects the response to a stimulus with ximelagatran."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to ximelagatran trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to ximelagatran"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to iloperidone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with iloperidone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to iloperidone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to iloperidone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to losartan) + +AnnotationAssertion( "A trait that affects the response to a stimulus with losartan."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to losartan trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to losartan"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to ivacaftor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with ivacaftor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to ivacaftor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to ivacaftor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to metformin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with metformin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to metformin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to metformin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to mTOR inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with mTOR inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to mTOR inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to mTOR inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to methylphenidate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with methylphenidate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to methylphenidate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to methylphenidate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to topoisomerase inhibitor) + +AnnotationAssertion( "A trait that affects the response to a stimulus with topoisomerase inhibitor."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to topoisomerase inhibitor trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to topoisomerase inhibitor"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + +# Class: (trait in response to dabigatran etexilate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with dabigatran etexilate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to dabigatran etexilate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to dabigatran etexilate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to omacetaxine mepesuccinate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with omacetaxine mepesuccinate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to omacetaxine mepesuccinate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to omacetaxine mepesuccinate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to tofacitinib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tofacitinib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tofacitinib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tofacitinib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to pazopanib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with pazopanib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to pazopanib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to pazopanib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to nitrofurantoin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with nitrofurantoin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to nitrofurantoin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to nitrofurantoin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to triamcinolone acetonide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with triamcinolone acetonide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to triamcinolone acetonide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to triamcinolone acetonide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to temozolomide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with temozolomide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to temozolomide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to temozolomide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to dabrafenib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with dabrafenib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to dabrafenib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to dabrafenib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to trametinib) + +AnnotationAssertion( "A trait that affects the response to a stimulus with trametinib."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to trametinib trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to trametinib"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to dimethyl fumarate) + +AnnotationAssertion( "A trait that affects the response to a stimulus with dimethyl fumarate."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to dimethyl fumarate trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to dimethyl fumarate"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to dolutegravir) + +AnnotationAssertion( "A trait that affects the response to a stimulus with dolutegravir."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to dolutegravir trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to dolutegravir"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to olanzapine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with olanzapine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to olanzapine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to olanzapine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to oxcarbazepine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with oxcarbazepine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to oxcarbazepine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to oxcarbazepine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to perphenazine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with perphenazine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to perphenazine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to perphenazine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to irinotecan) + +AnnotationAssertion( "A trait that affects the response to a stimulus with irinotecan."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to irinotecan trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to irinotecan"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to phenylephrine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with phenylephrine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to phenylephrine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to phenylephrine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to phenytoin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with phenytoin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to phenytoin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to phenytoin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to 4-(4-Hydroxyphenyl)-2-butanol) + +AnnotationAssertion( "A trait that affects the response to a stimulus with 4-(4-Hydroxyphenyl)-2-butanol."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to 4-(4-Hydroxyphenyl)-2-butanol trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 4-(4-Hydroxyphenyl)-2-butanol"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to paliperidone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with paliperidone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to paliperidone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to paliperidone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to prednisolone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with prednisolone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to prednisolone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to prednisolone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to quetiapine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with quetiapine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to quetiapine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to quetiapine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to risperidone) + +AnnotationAssertion( "A trait that affects the response to a stimulus with risperidone."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to risperidone trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to risperidone"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to simvastatin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with simvastatin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to simvastatin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to simvastatin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to sulfasalazine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with sulfasalazine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to sulfasalazine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to sulfasalazine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to tamsulosin) + +AnnotationAssertion( "A trait that affects the response to a stimulus with tamsulosin."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to tamsulosin trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to tamsulosin"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to terbinafine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with terbinafine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to terbinafine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to terbinafine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to Triptolide) + +AnnotationAssertion( "A trait that affects the response to a stimulus with Triptolide."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to Triptolide trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to Triptolide"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to venlafaxine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with venlafaxine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to venlafaxine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to venlafaxine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (age of onset of cancer) + +AnnotationAssertion( "The age at which cancer manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of cancer"^^xsd:string) +AnnotationAssertion( "age cancer symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of cancer"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of glaucoma) + +AnnotationAssertion( "The age at which glaucoma manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of glaucoma"^^xsd:string) +AnnotationAssertion( "age glaucoma symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of glaucoma"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of stroke disorder) + +AnnotationAssertion( "The age at which stroke disorder manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of stroke disorder"^^xsd:string) +AnnotationAssertion( "age stroke disorder symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of stroke disorder"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of coronary stenosis) + +AnnotationAssertion( "The age at which coronary stenosis manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of coronary stenosis"^^xsd:string) +AnnotationAssertion( "age coronary stenosis symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of coronary stenosis"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of glioblastoma) + +AnnotationAssertion( "The age at which glioblastoma manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of glioblastoma"^^xsd:string) +AnnotationAssertion( "age glioblastoma symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of glioblastoma"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of systemic lupus erythematosus) + +AnnotationAssertion( "The age at which systemic lupus erythematosus manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of systemic lupus erythematosus"^^xsd:string) +AnnotationAssertion( "age systemic lupus erythematosus symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of systemic lupus erythematosus"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of hypertensive disorder) + +AnnotationAssertion( "The age at which hypertensive disorder manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of hypertensive disorder"^^xsd:string) +AnnotationAssertion( "age hypertensive disorder symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of hypertensive disorder"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of Machado-Joseph disease) + +AnnotationAssertion( "The age at which Machado-Joseph disease manifestations first appear."^^xsd:string) +AnnotationAssertion( "age Machado-Joseph disease symptoms begin"^^xsd:string) +AnnotationAssertion( "age at onset of Machado-Joseph disease"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of Machado-Joseph disease"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (age of onset of major depressive disorder) + +AnnotationAssertion( "The age at which major depressive disorder manifestations first appear."^^xsd:string) +AnnotationAssertion( "age at onset of major depressive disorder"^^xsd:string) +AnnotationAssertion( "age major depressive disorder symptoms begin"^^xsd:string) +AnnotationAssertion(rdfs:label "age of onset of major depressive disorder"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (trait in response to methamphetamine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with methamphetamine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to methamphetamine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to methamphetamine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to cocaine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with cocaine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to cocaine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to cocaine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to nicotine) + +AnnotationAssertion( "A trait that affects the response to a stimulus with nicotine."^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) +AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) +AnnotationAssertion( "response to nicotine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to nicotine"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + # Class: (mammary gland secreted fluid morphology trait) AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a mammary gland fluid/secretion."^^xsd:string) @@ -57846,8 +59793,8 @@ EquivalentClasses( ObjectIntersect # Class: (podocyte morphology trait) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of glomerular visceral epithelial cell"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of podocyte"^^xsd:string) AnnotationAssertion(rdfs:label "podocyte morphology trait"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -63808,7 +65755,6 @@ SubClassOf(ObjectIntersectionOf( Ob SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) -SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) @@ -69413,6 +71359,7 @@ SubClassOf(ObjectIntersectionOf( Ob SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) @@ -70452,7 +72399,7 @@ SubClassOf(ObjectIntersectionOf( Ob SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) -SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) @@ -70551,7 +72498,6 @@ SubClassOf(ObjectIntersectionOf( Ob SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) -SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) @@ -70579,6 +72525,7 @@ SubClassOf(ObjectIntersectionOf( Ob SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) diff --git a/patterns/pattern.owl b/patterns/pattern.owl index 8ceaf73d..0b5792ad 100644 --- a/patterns/pattern.owl +++ b/patterns/pattern.owl @@ -11,9 +11,11 @@ Ontology( Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -21,11 +23,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) @@ -67,7 +73,7 @@ AnnotationAssertion( "age 'disease' symptoms begin"^^xsd:string) AnnotationAssertion( "age at onset of 'disease'"^^xsd:string) AnnotationAssertion(rdfs:label "age of onset of 'disease'"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: ('thing' 'quality') @@ -93,6 +99,24 @@ AnnotationAssertion(Annotation( "'quality' of 'process' in 'thing'"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( owl:Thing))))) +# Class: (trait in response to 'chemical_entity') + +AnnotationAssertion( "A trait that affects the response to a stimulus with 'chemical_entity'."^^xsd:string) +AnnotationAssertion( "xsd:anyURI"^^xsd:string) +AnnotationAssertion( "response_to_chemical_stimulus_trait"^^xsd:string) +AnnotationAssertion( "response to 'chemical_entity' trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 'chemical_entity'"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) + +# Class: (trait in response to 'role') + +AnnotationAssertion( "A trait that affects the response to a stimulus with 'role'."^^xsd:string) +AnnotationAssertion( "xsd:anyURI"^^xsd:string) +AnnotationAssertion( "response_to_chemical_with_role_stimulus"^^xsd:string) +AnnotationAssertion( "response to 'role' trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 'role'"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( owl:Thing))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( owl:Thing)))) ) \ No newline at end of file diff --git a/src/ontology/imports/chebi_import.owl b/src/ontology/imports/chebi_import.owl index e8e42cdf..6097a5fa 100644 --- a/src/ontology/imports/chebi_import.owl +++ b/src/ontology/imports/chebi_import.owl @@ -14,8 +14,8 @@ xmlns:chebi4="http://purl.obolibrary.org/obo/chebi#1" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2022-05-06 + + 2022-08-03 @@ -2011,6 +2011,7 @@ + @@ -2101,6 +2102,34 @@ + + + + + A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group. + 0 + C9H13N + InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3 + KWTSXDURSIMDCE-UHFFFAOYSA-N + 135.207 + 135.10480 + C=1(C=CC=CC1)CC(C)N + 1-phenylpropan-2-amine + chebi_ontology + CHEBI:132233 + + 1-phenylpropan-2-amine + + + + + 1-phenylpropan-2-amine + IUPAC + + + + + @@ -2143,6 +2172,47 @@ + + + + + + + + + + + An organic cation obtained by protonation of the secondary amino function of methamphetamine. + +1 + C10H16N + InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/p+1/t9-/m0/s1 + MYWUZJCMWCOHBA-VIFPVBQESA-O + 150.241 + 150.12773 + C=1(C[C@@H]([NH2+]C)C)C=CC=CC1 + (2S)-N-methyl-1-phenylpropan-2-aminium + chebi_ontology + methamphetamine cation + CHEBI:132297 + + methamphetamine(1+) + + + + + (2S)-N-methyl-1-phenylpropan-2-aminium + IUPAC + + + + + + methamphetamine cation + ChEBI + + + + @@ -2218,6 +2288,7 @@ 1-[(2S)-2-azaniumyl-5-carbamimidamidopentanoyl]-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-N-[(1S)-4-carbamimidamido-1-carboxylatobutyl]-L-phenylalaninamide 1-[(2S)-2-azaniumyl-5-{[azaniumyl(imino)methyl]amino}pentanoyl]-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-N-[(1S)-4-{[azaniumyl(imino)methyl]amino}-1-carboxylatobutyl]-L-phenylalaninamide chebi_ontology + bradykinin CHEBI:132988 bradykinin(2+) @@ -2236,6 +2307,12 @@ IUPAC + + + + bradykinin + UniProt + @@ -3260,6 +3337,36 @@ + + + + + + + An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 + SNICXCGAKADSCV-UHFFFAOYSA-N + 162.232 + 162.11570 + C=1C=C(C2N(CCC2)C)C=NC1 + 3-(1-methylpyrrolidin-2-yl)pyridine + chebi_ontology + CHEBI:138000 + + 3-(1-methylpyrrolidin-2-yl)pyridine + + + + + 3-(1-methylpyrrolidin-2-yl)pyridine + IUPAC + + + + + @@ -16452,9 +16559,9 @@ C33H36N4O6 InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14- BPYKTIZUTYGOLE-IFADSCNNSA-N - 584.66230 + 584.673 584.26348 - CC1=C(C=C)\C(NC1=O)=C\c1[nH]c(Cc2[nH]c(\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC(O)=O)c(CCC(O)=O)c1C + CC1=C(C=C)\C(NC1=O)=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\C=C2/NC(=O)C(C=C)=C2C)N1 CHEBI:13898 CHEBI:22870 CHEBI:3099 @@ -16465,9 +16572,12 @@ KEGG:C00486 KNApSAcK:C00029828 MetaCyc:BILIRUBIN + PDBeChem:BLR PMID:12799017 PMID:18442622 PMID:23763371 + PMID:23768684 + PMID:30224965 PMID:8605219 PMID:9587403 Reaxys:74376 @@ -16528,6 +16638,18 @@ PMID:23763371 Europe PMC + + + + PMID:23768684 + Europe PMC + + + + + PMID:30224965 + Europe PMC + @@ -23100,6 +23222,948 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 + SNICXCGAKADSCV-JTQLQIEISA-N + 162.232 + 162.11570 + C=1C=C([C@]2(N(CCC2)C)[H])C=NC1 + CHEBI:14653 + CHEBI:25536 + CHEBI:44268 + CHEBI:7562 + BPDB:485 + Beilstein:3604351 + Beilstein:82109 + CAS:54-11-5 + DrugBank:DB00184 + Drug_Central:1920 + HMDB:HMDB0001934 + KEGG:C00745 + KEGG:D03365 + KNApSAcK:C00002057 + LINCS:LSM-2093 + MetaCyc:NICOTINE + PDBeChem:NCT + PMID:11209966 + PMID:11322615 + PMID:11406005 + PMID:11719700 + PMID:11768184 + PMID:11821649 + PMID:11851194 + PMID:12575980 + PMID:12692774 + PMID:12769614 + PMID:12850578 + PMID:12971663 + PMID:13590907 + PMID:14674846 + PMID:14761239 + PMID:14975706 + PMID:15019421 + PMID:15027713 + PMID:15251917 + PMID:15276225 + PMID:15380834 + PMID:15502843 + PMID:15527885 + PMID:15707677 + PMID:15734728 + PMID:15826609 + PMID:15894687 + PMID:15902919 + PMID:15960296 + PMID:15963341 + PMID:16059663 + PMID:16212709 + PMID:16333621 + PMID:16370520 + PMID:16496293 + PMID:17023324 + PMID:17206646 + PMID:17292347 + PMID:17350101 + PMID:17498763 + PMID:17504235 + PMID:17525204 + PMID:17560039 + PMID:17683794 + PMID:18380035 + PMID:18383130 + PMID:18490768 + PMID:18683238 + PMID:18685152 + PMID:18805442 + PMID:18922921 + PMID:19100291 + PMID:19100331 + PMID:19287496 + PMID:19389046 + PMID:19448649 + PMID:19465085 + PMID:19850423 + PMID:19954906 + PMID:21521420 + PMID:21636612 + PMID:21822688 + PMID:21945235 + PMID:21947355 + PMID:22030716 + PMID:22129149 + PMID:22218403 + PMID:22265518 + PMID:22331007 + PMID:22377934 + PMID:22459798 + PMID:22529223 + PMID:22530136 + PMID:27951416 + PMID:28187919 + PMID:28391535 + PMID:28574230 + PMID:28641297 + PMID:28678400 + PMID:28683421 + PMID:28686840 + PMID:28698187 + PMID:28700952 + PMID:28704277 + PMID:28710519 + PMID:28711472 + PMID:28714396 + PMID:28718768 + PMID:28718828 + PMID:28726253 + PMID:28735272 + Reaxys:82109 + Wikipedia:Nicotine + (S)-Nicotine + (S)-nicotine + 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine + chebi_ontology + (-)-3-(1-Methyl-2-pyrrolidyl)pyridine + (-)-3-(N-Methylpyrrolidino)pyridine + (-)-nicotine + (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine + (S)-(-)-nicotine + (S)-3-(1-methylpyrrolidin-2-yl)pyridine + (S)-3-(N-methylpyrrolidin-2-yl)pyridine + 1-Methyl-2-(3-pyridyl)pyrrolidine + 3-(1-Methyl-2-pyrollidinyl)pyridine + 3-(1-Methylpyrrolidin-2-yl)pyridine + 3-(2-(N-methylpyrrolidinyl))pyridine + 3-(N-methylpyrollidino)pyridine + L(-)-nicotine + L-3-(1-Methyl-2-pyrrolidyl)pyridine + L-Nicotine + Nicotine + CHEBI:17688 + + (S)-nicotine + + + + + Beilstein:3604351 + Beilstein + + + + + Beilstein:82109 + Beilstein + + + + + CAS:54-11-5 + ChemIDplus + + + + + CAS:54-11-5 + KEGG COMPOUND + + + + + CAS:54-11-5 + NIST Chemistry WebBook + + + + + Drug_Central:1920 + DrugCentral + + + + + PMID:11209966 + Europe PMC + + + + + PMID:11322615 + Europe PMC + + + + + PMID:11406005 + Europe PMC + + + + + PMID:11719700 + Europe PMC + + + + + PMID:11768184 + Europe PMC + + + + + PMID:11821649 + Europe PMC + + + + + PMID:11851194 + Europe PMC + + + + + PMID:12575980 + Europe PMC + + + + + PMID:12692774 + Europe PMC + + + + + PMID:12769614 + Europe PMC + + + + + PMID:12850578 + Europe PMC + + + + + PMID:12971663 + Europe PMC + + + + + PMID:13590907 + Europe PMC + + + + + PMID:14674846 + Europe PMC + + + + + PMID:14761239 + Europe PMC + + + + + PMID:14975706 + Europe PMC + + + + + PMID:15019421 + Europe PMC + + + + + PMID:15027713 + Europe PMC + + + + + PMID:15251917 + Europe PMC + + + + + PMID:15276225 + Europe PMC + + + + + PMID:15380834 + Europe PMC + + + + + PMID:15502843 + Europe PMC + + + + + PMID:15527885 + Europe PMC + + + + + PMID:15707677 + Europe PMC + + + + + PMID:15734728 + Europe PMC + + + + + PMID:15826609 + Europe PMC + + + + + PMID:15894687 + Europe PMC + + + + + PMID:15902919 + Europe PMC + + + + + PMID:15960296 + Europe PMC + + + + + PMID:15963341 + Europe PMC + + + + + PMID:16059663 + Europe PMC + + + + + PMID:16212709 + Europe PMC + + + + + PMID:16333621 + Europe PMC + + + + + PMID:16370520 + Europe PMC + + + + + PMID:16496293 + Europe PMC + + + + + PMID:17023324 + Europe PMC + + + + + PMID:17206646 + Europe PMC + + + + + PMID:17292347 + Europe PMC + + + + + PMID:17350101 + Europe PMC + + + + + PMID:17498763 + Europe PMC + + + + + PMID:17504235 + Europe PMC + + + + + PMID:17525204 + Europe PMC + + + + + PMID:17560039 + Europe PMC + + + + + PMID:17683794 + Europe PMC + + + + + PMID:18380035 + Europe PMC + + + + + PMID:18383130 + Europe PMC + + + + + PMID:18490768 + Europe PMC + + + + + PMID:18683238 + Europe PMC + + + + + PMID:18685152 + Europe PMC + + + + + PMID:18805442 + Europe PMC + + + + + PMID:18922921 + Europe PMC + + + + + PMID:19100291 + Europe PMC + + + + + PMID:19100331 + Europe PMC + + + + + PMID:19287496 + Europe PMC + + + + + PMID:19389046 + Europe PMC + + + + + PMID:19448649 + Europe PMC + + + + + PMID:19465085 + Europe PMC + + + + + PMID:19850423 + Europe PMC + + + + + PMID:19954906 + Europe PMC + + + + + PMID:21521420 + Europe PMC + + + + + PMID:21636612 + Europe PMC + + + + + PMID:21822688 + Europe PMC + + + + + PMID:21945235 + Europe PMC + + + + + PMID:21947355 + Europe PMC + + + + + PMID:22030716 + Europe PMC + + + + + PMID:22129149 + Europe PMC + + + + + PMID:22218403 + Europe PMC + + + + + PMID:22265518 + Europe PMC + + + + + PMID:22331007 + Europe PMC + + + + + PMID:22377934 + Europe PMC + + + + + PMID:22459798 + Europe PMC + + + + + PMID:22529223 + Europe PMC + + + + + PMID:22530136 + Europe PMC + + + + + PMID:27951416 + Europe PMC + + + + + PMID:28187919 + Europe PMC + + + + + PMID:28391535 + Europe PMC + + + + + PMID:28574230 + Europe PMC + + + + + PMID:28641297 + Europe PMC + + + + + PMID:28678400 + Europe PMC + + + + + PMID:28683421 + Europe PMC + + + + + PMID:28686840 + Europe PMC + + + + + PMID:28698187 + Europe PMC + + + + + PMID:28700952 + Europe PMC + + + + + PMID:28704277 + Europe PMC + + + + + PMID:28710519 + Europe PMC + + + + + PMID:28711472 + Europe PMC + + + + + PMID:28714396 + Europe PMC + + + + + PMID:28718768 + Europe PMC + + + + + PMID:28718828 + Europe PMC + + + + + PMID:28726253 + Europe PMC + + + + + PMID:28735272 + Europe PMC + + + + + Reaxys:82109 + Reaxys + + + + + (S)-Nicotine + KEGG_COMPOUND + + + + + (S)-nicotine + ChemIDplus + + + + + 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine + IUPAC + + + + + + (-)-3-(1-Methyl-2-pyrrolidyl)pyridine + HMDB + + + + + (-)-3-(N-Methylpyrrolidino)pyridine + HMDB + + + + + (-)-nicotine + ChemIDplus + + + + + (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine + HMDB + + + + + (S)-(-)-nicotine + NIST_Chemistry_WebBook + + + + + (S)-3-(1-methylpyrrolidin-2-yl)pyridine + KEGG_COMPOUND + + + + + (S)-3-(N-methylpyrrolidin-2-yl)pyridine + IUBMB + + + + + 1-Methyl-2-(3-pyridyl)pyrrolidine + HMDB + + + + + 3-(1-Methyl-2-pyrollidinyl)pyridine + HMDB + + + + + 3-(1-Methylpyrrolidin-2-yl)pyridine + HMDB + + + + + 3-(2-(N-methylpyrrolidinyl))pyridine + NIST_Chemistry_WebBook + + + + + 3-(N-methylpyrollidino)pyridine + NIST_Chemistry_WebBook + + + + + L(-)-nicotine + IUBMB + + + + + L-3-(1-Methyl-2-pyrrolidyl)pyridine + HMDB + + + + + L-Nicotine + HMDB + + + + + Nicotine + HMDB + + + + + Nicotine + KEGG_COMPOUND + + + + @@ -28685,6 +29749,685 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A racemate composed of equimolar amounts of (R)- and (S)-nicotine. + Beilstein:82108 + Beilstein:82111 + CAS:22083-74-5 + DrugBank:DB00184 + HMDB:HMDB0014330 + KEGG:C16150 + KNApSAcK:C00002057 + PMID:10751565 + PMID:11192937 + PMID:11471991 + PMID:11559179 + PMID:11682702 + PMID:11714820 + PMID:11719700 + PMID:11801622 + PMID:11818389 + PMID:11860617 + PMID:12197757 + PMID:12700710 + PMID:12965231 + PMID:14715938 + PMID:15183514 + PMID:15251917 + PMID:15313135 + PMID:15458549 + PMID:15707677 + PMID:15894687 + PMID:15960296 + PMID:15961264 + PMID:16496293 + PMID:16950410 + PMID:17167832 + PMID:17206646 + PMID:17438652 + PMID:17498149 + PMID:17942810 + PMID:18077004 + PMID:18311975 + PMID:18380035 + PMID:18383130 + PMID:18651995 + PMID:18922921 + PMID:19100331 + PMID:19287496 + PMID:19389046 + PMID:19465085 + PMID:20338106 + PMID:20528766 + PMID:21636612 + PMID:21822688 + PMID:21945235 + PMID:22129149 + PMID:22218403 + PMID:22331007 + PMID:22377934 + PMID:22448647 + PMID:22459798 + PMID:22529223 + PMID:22573728 + PMID:22585541 + PMID:22589423 + PMID:22770225 + PMID:22792725 + PMID:22855884 + PMID:22930863 + PMID:22935730 + PMID:23108361 + PMID:23117126 + PMID:7097594 + PMID:7564279 + PMID:7566693 + PMID:7807214 + PMID:7896575 + PMID:8156919 + PMID:8545712 + PMID:8764340 + PMID:9203638 + PMID:9450943 + PMID:9621392 + Reaxys:82108 + UM-BBD_compID:c0468 + Wikipedia:Nicotine + rac-3-(1-methylpyrrolidin-2-yl)pyridine + chebi_ontology + (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine + (+-)-nicotine + (R,S)-nicotine + (RS)-nicotine + nicotin + nikotin + CHEBI:18723 + + nicotine + + + + + Beilstein:82108 + Beilstein + + + + + Beilstein:82111 + Beilstein + + + + + CAS:22083-74-5 + ChemIDplus + + + + + CAS:22083-74-5 + KEGG COMPOUND + + + + + PMID:10751565 + Europe PMC + + + + + PMID:11192937 + Europe PMC + + + + + PMID:11471991 + Europe PMC + + + + + PMID:11559179 + Europe PMC + + + + + PMID:11682702 + Europe PMC + + + + + PMID:11714820 + Europe PMC + + + + + PMID:11719700 + Europe PMC + + + + + PMID:11801622 + Europe PMC + + + + + PMID:11818389 + Europe PMC + + + + + PMID:11860617 + Europe PMC + + + + + PMID:12197757 + Europe PMC + + + + + PMID:12700710 + Europe PMC + + + + + PMID:12965231 + Europe PMC + + + + + PMID:14715938 + Europe PMC + + + + + PMID:15183514 + Europe PMC + + + + + PMID:15251917 + Europe PMC + + + + + PMID:15313135 + Europe PMC + + + + + PMID:15458549 + Europe PMC + + + + + PMID:15707677 + Europe PMC + + + + + PMID:15894687 + Europe PMC + + + + + PMID:15960296 + Europe PMC + + + + + PMID:15961264 + Europe PMC + + + + + PMID:16496293 + Europe PMC + + + + + PMID:16950410 + Europe PMC + + + + + PMID:17167832 + Europe PMC + + + + + PMID:17206646 + Europe PMC + + + + + PMID:17438652 + Europe PMC + + + + + PMID:17498149 + Europe PMC + + + + + PMID:17942810 + Europe PMC + + + + + PMID:18077004 + Europe PMC + + + + + PMID:18311975 + Europe PMC + + + + + PMID:18380035 + Europe PMC + + + + + PMID:18383130 + Europe PMC + + + + + PMID:18651995 + Europe PMC + + + + + PMID:18922921 + Europe PMC + + + + + PMID:19100331 + Europe PMC + + + + + PMID:19287496 + Europe PMC + + + + + PMID:19389046 + Europe PMC + + + + + PMID:19465085 + Europe PMC + + + + + PMID:20338106 + Europe PMC + + + + + PMID:20528766 + Europe PMC + + + + + PMID:21636612 + Europe PMC + + + + + PMID:21822688 + Europe PMC + + + + + PMID:21945235 + Europe PMC + + + + + PMID:22129149 + Europe PMC + + + + + PMID:22218403 + Europe PMC + + + + + PMID:22331007 + Europe PMC + + + + + PMID:22377934 + Europe PMC + + + + + PMID:22448647 + Europe PMC + + + + + PMID:22459798 + Europe PMC + + + + + PMID:22529223 + Europe PMC + + + + + PMID:22573728 + Europe PMC + + + + + PMID:22585541 + Europe PMC + + + + + PMID:22589423 + Europe PMC + + + + + PMID:22770225 + Europe PMC + + + + + PMID:22792725 + Europe PMC + + + + + PMID:22855884 + Europe PMC + + + + + PMID:22930863 + Europe PMC + + + + + PMID:22935730 + Europe PMC + + + + + PMID:23108361 + Europe PMC + + + + + PMID:23117126 + Europe PMC + + + + + PMID:7097594 + Europe PMC + + + + + PMID:7564279 + Europe PMC + + + + + PMID:7566693 + Europe PMC + + + + + PMID:7807214 + Europe PMC + + + + + PMID:7896575 + Europe PMC + + + + + PMID:8156919 + Europe PMC + + + + + PMID:8545712 + Europe PMC + + + + + PMID:8764340 + Europe PMC + + + + + PMID:9203638 + Europe PMC + + + + + PMID:9450943 + Europe PMC + + + + + PMID:9621392 + Europe PMC + + + + + Reaxys:82108 + Reaxys + + + + + UM-BBD_compID:c0468 + UM-BBD + + + + + rac-3-(1-methylpyrrolidin-2-yl)pyridine + IUPAC + + + + + + (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine + KEGG_COMPOUND + + + + + (+-)-nicotine + ChemIDplus + + + + + (R,S)-nicotine + ChemIDplus + + + + + (RS)-nicotine + UM-BBD + + + + + nicotin + ChEBI + + + + + nikotin + ChEBI + + + + @@ -29967,6 +31710,7 @@ + A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid. chebi_ontology benzoate anion @@ -30359,6 +32103,40 @@ + + + + + An insecticide compound naturally occurring in plants. + chebi_ontology + botanical insecticide + botanical insecticides + phytogenic insecticides + CHEBI:22917 + + phytogenic insecticide + + + + + botanical insecticide + ChEBI + + + + + botanical insecticides + ChEBI + + + + + phytogenic insecticides + ChEBI + + + + @@ -33922,6 +35700,27 @@ + + + + + Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. + Wikipedia:Insecticide + chebi_ontology + insecticides + CHEBI:24852 + + insecticide + + + + + insecticides + ChEBI + + + + @@ -35457,6 +37256,12 @@ + + + + + + A hydroxybenzoate carrying a single hydroxy substituent at unspecified position. chebi_ontology monohydroxybenzoates @@ -35477,6 +37282,12 @@ + + + + + + Any hydroxybenzoic acid having a single phenolic hydroxy substituent on the benzene ring. chebi_ontology monohydroxybenzoic acids @@ -38275,6 +40086,26 @@ + + + + + + chebi_ontology + pyridine alkaloids + CHEBI:26416 + + pyridine alkaloid + + + + + pyridine alkaloids + ChEBI + + + + @@ -38377,6 +40208,26 @@ + + + + + + chebi_ontology + pyrrolidine alkaloids + CHEBI:26456 + + pyrrolidine alkaloid + + + + + pyrrolidine alkaloids + ChEBI + + + + @@ -42871,6 +44722,368 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. + 0 + C17H21NO4 + InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1 + ZPUCINDJVBIVPJ-LJISPDSOSA-N + 303.35290 + 303.14706 + [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C + CHEBI:23346 + CHEBI:3801 + CHEBI:41642 + Beilstein:3621912 + Beilstein:5291037 + Beilstein:91034 + CAS:50-36-2 + DrugBank:DB00907 + Drug_Central:723 + Gmelin:170209 + KEGG:C01416 + KEGG:D00110 + KNApSAcK:C00002285 + MetaCyc:CPD-9776 + PDBeChem:COC + PMID:11416615 + PMID:11853120 + PMID:14962054 + PMID:17551070 + PMID:19536276 + PMID:21150772 + PMID:25303034 + Reaxys:5291037 + Reaxys:91034 + Wikipedia:Cocaine + (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate + COCAINE + Cocaine + methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate + chebi_ontology + (-)-cocaine + 2-methyl-3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester) + Benzoylmethylecgonine + Cocain + Cocaina + Kokain + Neurocaine + [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester + beta-Cocain + cocainum + l-Cocain + l-cocaine + methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate + methyl benzoylecgonine + CHEBI:27958 + + cocaine + + + + + Beilstein:3621912 + Beilstein + + + + + Beilstein:5291037 + Beilstein + + + + + Beilstein:91034 + Beilstein + + + + + CAS:50-36-2 + ChemIDplus + + + + + CAS:50-36-2 + KEGG COMPOUND + + + + + CAS:50-36-2 + NIST Chemistry WebBook + + + + + Drug_Central:723 + DrugCentral + + + + + Gmelin:170209 + Gmelin + + + + + PMID:11416615 + Europe PMC + + + + + PMID:11853120 + Europe PMC + + + + + PMID:14962054 + Europe PMC + + + + + PMID:17551070 + Europe PMC + + + + + PMID:19536276 + Europe PMC + + + + + PMID:21150772 + Europe PMC + + + + + PMID:25303034 + Europe PMC + + + + + Reaxys:5291037 + Reaxys + + + + + Reaxys:91034 + Reaxys + + + + + (1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate + IUPAC + + + + + + COCAINE + PDBeChem + + + + + Cocaine + KEGG_COMPOUND + + + + + methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate + IUPAC + + + + + + (-)-cocaine + ChEBI + + + + + 2-methyl-3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester) + NIST_Chemistry_WebBook + + + + + Benzoylmethylecgonine + ChemIDplus + + + + + Cocain + DrugBank + + + + + Cocaina + DrugBank + + + + + Kokain + ChEBI + + + + + Kokain + ChemIDplus + + + + + Neurocaine + ChemIDplus + + + + + [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester + NIST_Chemistry_WebBook + + + + + beta-Cocain + KEGG_COMPOUND + + + + + cocainum + ChEBI + + + + + l-Cocain + KEGG_COMPOUND + + + + + l-cocaine + ChemIDplus + + + + + methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate + ChEBI + + + + + methyl benzoylecgonine + ChemIDplus + + + + @@ -65434,6 +67647,32 @@ + + + + + + + + + + + Amines that constitute a class of central nervous system stimulants based on the structure of the parent amphetamine 1-phenylpropan-2-amine. + chebi_ontology + amphetamine drug + CHEBI:35338 + + amphetamines + + + + + amphetamine drug + ChEBI + + + + @@ -72003,6 +74242,7 @@ + @@ -72026,6 +74266,55 @@ + + + + + Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. + local anaesthetic + chebi_ontology + Lokalanaesthetikum + anesthesique local + local anaesthetics + local anesthetics + CHEBI:36333 + + local anaesthetic + + + + + local anaesthetic + IUPAC + + + + + + Lokalanaesthetikum + ChEBI + + + + + anesthesique local + ChEBI + + + + + local anaesthetics + ChEBI + + + + + local anesthetics + ChEBI + + + + @@ -75235,6 +77524,28 @@ + + + + + + CHEBI:27154 + CHEBI:27155 + chebi_ontology + tropane alkaloids + CHEBI:37332 + + tropane alkaloid + + + + + tropane alkaloids + ChEBI + + + + @@ -79363,6 +81674,26 @@ + + + + + + chebi_ontology + azabicycloalkanes + CHEBI:38295 + + azabicycloalkane + + + + + azabicycloalkanes + ChEBI + + + + @@ -79462,6 +81793,61 @@ + + + + + Any drug that binds to and activates cholinergic receptors. + chebi_ontology + acetylcholine agonist + acetylcholine agonists + acetylcholine receptor agonist + cholinergic agonists + cholinomimetic + cholinomimetics + CHEBI:38324 + + cholinergic agonist + + + + + acetylcholine agonist + ChEBI + + + + + acetylcholine agonists + ChEBI + + + + + acetylcholine receptor agonist + IUPHAR + + + + + cholinergic agonists + ChEBI + + + + + cholinomimetic + ChEBI + + + + + cholinomimetics + ChEBI + + + + @@ -81543,6 +83929,96 @@ + + + + + + + + + + + + + + + + + A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has R-configuration. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m1/s1 + SNICXCGAKADSCV-SNVBAGLBSA-N + 162.23160 + 162.11570 + CN1CCC[C@@H]1c1cccnc1 + Beilstein:4666243 + Beilstein:82110 + CAS:25162-00-9 + KEGG:C16386 + 3-[(2R)-1-methylpyrrolidin-2-yl]pyridine + chebi_ontology + (+)-nicotine + (R)-3-(1-methyl-2-pyrrolidinyl)pyridine + d-nicotine + pseudonicotine + CHEBI:39162 + + (R)-nicotine + + + + + Beilstein:4666243 + ChemIDplus + + + + + Beilstein:82110 + Beilstein + + + + + CAS:25162-00-9 + ChemIDplus + + + + + 3-[(2R)-1-methylpyrrolidin-2-yl]pyridine + IUPAC + + + + + + (+)-nicotine + ChemIDplus + + + + + (R)-3-(1-methyl-2-pyrrolidinyl)pyridine + ChemIDplus + + + + + d-nicotine + ChemIDplus + + + + + pseudonicotine + ChemIDplus + + + + @@ -86157,6 +88633,119 @@ + + + + + + + + + + + A 1-phenylpropan-2-amine that has R configuration. + 0 + C9H13N + InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m1/s1 + KWTSXDURSIMDCE-MRVPVSSYSA-N + 135.20626 + 135.10480 + C[C@@H](N)Cc1ccccc1 + CHEBI:35339 + CHEBI:42720 + Beilstein:2432739 + CAS:156-34-3 + Drug_Central:1562 + Gmelin:1125855 + (2R)-1-phenylpropan-2-amine + (R)-amphetamine + chebi_ontology + (-)-amphetamine + (-)-phenylisopropylamine + (R)-alpha-methylbenzeneethanamine + (R)-alpha-methylphenethylamine + levamfetamine + levamphetamine + CHEBI:42724 + + (R)-amphetamine + + + + + Beilstein:2432739 + Beilstein + + + + + CAS:156-34-3 + ChemIDplus + + + + + Drug_Central:1562 + DrugCentral + + + + + Gmelin:1125855 + Gmelin + + + + + (2R)-1-phenylpropan-2-amine + IUPAC + + + + + + (R)-amphetamine + ChemIDplus + + + + + (-)-amphetamine + ChemIDplus + + + + + (-)-phenylisopropylamine + ChemIDplus + + + + + (R)-alpha-methylbenzeneethanamine + ChemIDplus + + + + + (R)-alpha-methylphenethylamine + ChemIDplus + + + + + levamfetamine + ChemIDplus + + + + + levamphetamine + ChemIDplus + + + + @@ -86793,6 +89382,267 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A 1-phenylpropan-2-amine that has S configuration. + 0 + C9H13N + InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1 + KWTSXDURSIMDCE-QMMMGPOBSA-N + 135.20626 + 135.10480 + C[C@H](N)Cc1ccccc1 + Beilstein:2205872 + CAS:51-64-9 + DrugBank:DB01576 + Drug_Central:841 + Gmelin:1125854 + KEGG:C07884 + KEGG:D03740 + PMID:22129527 + PMID:22894820 + PMID:23360956 + PMID:23851485 + PMID:23881044 + PMID:23907377 + PMID:24349338 + Wikipedia:Dextroamphetamine + (2S)-1-phenylpropan-2-amine + (S)-amphetamine + chebi_ontology + (+)-(S)-amphetamine + (+)-alpha-methylphenethylamine + (+)-alpha-methylphenylethylamine + (+)-amphetamine + (S)-(+)-amphetamine + (S)-(+)-beta-phenylisopropylamine + (S)-1-phenyl-2-aminopropane + (S)-1-phenyl-2-propylamine + (S)-alpha-methylbenzeneethanamine + (alphaS)-alpha-methylbenzeneethanamine + Dextroamphetamine + d-amphetamine + dexamphetamine + CHEBI:4469 + + (S)-amphetamine + + + + + Beilstein:2205872 + ChemIDplus + + + + + CAS:51-64-9 + ChemIDplus + + + + + CAS:51-64-9 + KEGG COMPOUND + + + + + CAS:51-64-9 + NIST Chemistry WebBook + + + + + Drug_Central:841 + DrugCentral + + + + + Gmelin:1125854 + Gmelin + + + + + PMID:22129527 + Europe PMC + + + + + PMID:22894820 + Europe PMC + + + + + PMID:23360956 + Europe PMC + + + + + PMID:23851485 + Europe PMC + + + + + PMID:23881044 + Europe PMC + + + + + PMID:23907377 + Europe PMC + + + + + PMID:24349338 + Europe PMC + + + + + (2S)-1-phenylpropan-2-amine + IUPAC + + + + + + (S)-amphetamine + NIST_Chemistry_WebBook + + + + + (+)-(S)-amphetamine + ChemIDplus + + + + + (+)-alpha-methylphenethylamine + NIST_Chemistry_WebBook + + + + + (+)-alpha-methylphenylethylamine + NIST_Chemistry_WebBook + + + + + (+)-amphetamine + ChEBI + + + + + (S)-(+)-amphetamine + ChemIDplus + + + + + (S)-(+)-beta-phenylisopropylamine + NIST_Chemistry_WebBook + + + + + (S)-1-phenyl-2-aminopropane + ChemIDplus + + + + + (S)-1-phenyl-2-propylamine + ChemIDplus + + + + + (S)-alpha-methylbenzeneethanamine + ChemIDplus + + + + + (alphaS)-alpha-methylbenzeneethanamine + ChemIDplus + + + + + Dextroamphetamine + KEGG_COMPOUND + + + + + d-amphetamine + ChemIDplus + + + + + dexamphetamine + NIST_Chemistry_WebBook + + + + @@ -88135,6 +90985,26 @@ + + + + + + chebi_ontology + N-alkylpyrrolidines + CHEBI:46775 + + N-alkylpyrrolidine + + + + + N-alkylpyrrolidines + ChEBI + + + + @@ -88539,18 +91409,6 @@ L-erythro-sphingosine - - - - Beilstein:4352185 - Beilstein - - - - - CAS:6036-75-5 - ChemIDplus - @@ -88576,6 +91434,18 @@ L-erythro-sphing-4-enine ChEBI + + + + Beilstein:4352185 + Beilstein + + + + + CAS:6036-75-5 + ChemIDplus + @@ -89357,6 +92227,26 @@ + + + + + Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc. + chebi_ontology + Indikator + CHEBI:47867 + + indicator + + + + + Indikator + ChEBI + + + + @@ -89518,6 +92408,49 @@ + + + + + An agonist that selectively binds to and activates a nicotinic acetylcholine receptor. + CHEBI:82738 + Wikipedia:Nicotinic_acetylcholine_receptor + chebi_ontology + muscarinic agonists + nicotinic acetylcholine receptor agonists + nicotinic agonist + nicotinic agonists + CHEBI:47958 + + nicotinic acetylcholine receptor agonist + + + + + muscarinic agonists + ChEBI + + + + + nicotinic acetylcholine receptor agonists + ChEBI + + + + + nicotinic agonist + ChEBI + + + + + nicotinic agonists + ChEBI + + + + @@ -92261,12 +95194,6 @@ lithium(1+) - - - - lithium, ion - NIST_Chemistry_WebBook - @@ -92336,6 +95263,12 @@ lithium cation NIST_Chemistry_WebBook + + + + lithium, ion + NIST_Chemistry_WebBook + @@ -102556,6 +105489,26 @@ + + + + + A substance used as an indicator of a biological state. + chebi_ontology + biological marker + CHEBI:59163 + + biomarker + + + + + biological marker + ChEBI + + + + @@ -103464,6 +106417,74 @@ + + + + + + + + + + + + + + + + + + + + + + + The conjugate acid of (S)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3. + +1 + C10H15N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m0/s1 + SNICXCGAKADSCV-JTQLQIEISA-O + 163.23900 + 163.12297 + C[NH+]1CCC[C@H]1c1cccnc1 + Gmelin:329042 + MetaCyc:NICOTINE + (2S)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + chebi_ontology + (S)-nicotine + (S)-nicotinium cation + CHEBI:59806 + + (S)-nicotinium(1+) + + + + + Gmelin:329042 + Gmelin + + + + + (2S)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + IUPAC + + + + + + (S)-nicotine + UniProt + + + + + (S)-nicotinium cation + ChEBI + + + + @@ -104007,6 +107028,75 @@ + + + + + + + + + + + + + + + + + + The conjugate base of cocaine arising from protonation of the tertiary amino group; major species at pH 7.3. + +1 + C17H22NO4 + InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/p+1/t12-,13+,14-,15+/m0/s1 + ZPUCINDJVBIVPJ-LJISPDSOSA-O + 304.36090 + 304.15433 + [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)[NH+]2C + Gmelin:2542129 + Gmelin:341636 + (1R,2R,3S,5S)-3-(benzoyloxy)-2-(methoxycarbonyl)-8-methyl-8-azoniabicyclo[3.2.1]octane + chebi_ontology + cocaine + cocaine cation + CHEBI:60056 + + cocaine(1+) + + + + + Gmelin:2542129 + Gmelin + + + + + Gmelin:341636 + Gmelin + + + + + (1R,2R,3S,5S)-3-(benzoyloxy)-2-(methoxycarbonyl)-8-methyl-8-azoniabicyclo[3.2.1]octane + IUPAC + + + + + + cocaine + UniProt + + + + + cocaine cation + ChEBI + + + + @@ -106292,7 +109382,6 @@ - @@ -107802,7 +110891,7 @@ - A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is sustituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. + A sulfonamide that is N-phenylmethanesulfonamide in which the phenyl group is substituted at position 4 by a 1-hydroxy-2-(isopropylamino)ethyl group. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. 0 C12H20N2O3S InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 @@ -113113,6 +116202,455 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent. + 0 + C10H15N + InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3/t9-/m0/s1 + MYWUZJCMWCOHBA-VIFPVBQESA-N + 149.23284 + 149.12045 + CN[C@@H](C)Cc1ccccc1 + Beilstein:2207147 + CAS:537-46-2 + DrugBank:DB01577 + Drug_Central:1732 + HMDB:HMDB0015517 + KEGG:C07164 + KEGG:D08187 + PDBeChem:B40 + PMID:11221576 + PMID:11406298 + PMID:11711870 + PMID:11717374 + PMID:11829406 + PMID:11831503 + PMID:11847428 + PMID:11896153 + PMID:11984857 + PMID:14645148 + PMID:14769818 + PMID:15380623 + PMID:15542724 + PMID:15542728 + PMID:15808793 + PMID:18279499 + PMID:18509037 + PMID:18521756 + PMID:18991860 + PMID:18991862 + PMID:19269222 + PMID:19384581 + PMID:19576287 + PMID:19732271 + PMID:24349338 + PMID:25724762 + PMID:26302754 + PMID:26541330 + PMID:26568405 + PMID:26683901 + PMID:26775284 + PMID:26992824 + PMID:27232669 + Reaxys:2207147 + Wikipedia:Methamphetamine + (2S)-N-methyl-1-phenylpropan-2-amine + Methamphetamine + chebi_ontology + (+)-(S)-N-alpha-dimethylphenethylamine + (S)-N,alpha-dimethylbenzeneethanamine + (alphaS)-N,alpha-dimethylbenzeneethanamine + d-1-phenyl-2-methylaminopropane + d-N-methylamphetamine + d-deoxyephedrine + d-desoxyephedrine + d-phenylisopropylmethylamine + dextromethamphetamine + metamfetamine + metamfetaminum + metanfetamina + methyl-beta-phenylisopropylamine + CHEBI:6809 + + methamphetamine + + + + + Beilstein:2207147 + Beilstein + + + + + CAS:537-46-2 + ChemIDplus + + + + + CAS:537-46-2 + KEGG COMPOUND + + + + + CAS:537-46-2 + NIST Chemistry WebBook + + + + + Drug_Central:1732 + DrugCentral + + + + + PMID:11221576 + Europe PMC + + + + + PMID:11406298 + Europe PMC + + + + + PMID:11711870 + Europe PMC + + + + + PMID:11717374 + Europe PMC + + + + + PMID:11829406 + Europe PMC + + + + + PMID:11831503 + Europe PMC + + + + + PMID:11847428 + Europe PMC + + + + + PMID:11896153 + Europe PMC + + + + + PMID:11984857 + Europe PMC + + + + + PMID:14645148 + Europe PMC + + + + + PMID:14769818 + Europe PMC + + + + + PMID:15380623 + Europe PMC + + + + + PMID:15542724 + Europe PMC + + + + + PMID:15542728 + Europe PMC + + + + + PMID:15808793 + Europe PMC + + + + + PMID:18279499 + Europe PMC + + + + + PMID:18509037 + Europe PMC + + + + + PMID:18521756 + Europe PMC + + + + + PMID:18991860 + Europe PMC + + + + + PMID:18991862 + Europe PMC + + + + + PMID:19269222 + Europe PMC + + + + + PMID:19384581 + Europe PMC + + + + + PMID:19576287 + Europe PMC + + + + + PMID:19732271 + Europe PMC + + + + + PMID:24349338 + Europe PMC + + + + + PMID:25724762 + Europe PMC + + + + + PMID:26302754 + Europe PMC + + + + + PMID:26541330 + Europe PMC + + + + + PMID:26568405 + Europe PMC + + + + + PMID:26683901 + Europe PMC + + + + + PMID:26775284 + Europe PMC + + + + + PMID:26992824 + Europe PMC + + + + + PMID:27232669 + Europe PMC + + + + + Reaxys:2207147 + Reaxys + + + + + (2S)-N-methyl-1-phenylpropan-2-amine + IUPAC + + + + + + Methamphetamine + KEGG_COMPOUND + + + + + (+)-(S)-N-alpha-dimethylphenethylamine + NIST_Chemistry_WebBook + + + + + (S)-N,alpha-dimethylbenzeneethanamine + ChemIDplus + + + + + (alphaS)-N,alpha-dimethylbenzeneethanamine + ChemIDplus + + + + + d-1-phenyl-2-methylaminopropane + ChemIDplus + + + + + d-N-methylamphetamine + ChemIDplus + + + + + d-deoxyephedrine + ChemIDplus + + + + + d-desoxyephedrine + ChemIDplus + + + + + d-phenylisopropylmethylamine + ChemIDplus + + + + + dextromethamphetamine + ChEBI + + + + + metamfetamine + WHO_MedNet + + + + + + metamfetaminum + WHO_MedNet + + + + + + metanfetamina + WHO_MedNet + + + + + + methyl-beta-phenylisopropylamine + NIST_Chemistry_WebBook + + + + @@ -127694,6 +131232,61 @@ + + + + + + + + + + + + + + + + + + The conjugate acid of (R)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3. + +1 + C10H15N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m1/s1 + SNICXCGAKADSCV-SNVBAGLBSA-O + 163.23900 + 163.12297 + C[NH+]1CCC[C@@H]1c1cccnc1 + MetaCyc:R-NICOTINE + (2R)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + chebi_ontology + (R)-nicotine + CHEBI:79008 + + (R)-nicotinium(1+) + + + + + MetaCyc:R-NICOTINE + SUBMITTER + + + + + (2R)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + IUPAC + + + + + + (R)-nicotine + UniProt + + + + diff --git a/src/ontology/imports/cl_import.owl b/src/ontology/imports/cl_import.owl index 419cc7d2..9d2e0a08 100644 --- a/src/ontology/imports/cl_import.owl +++ b/src/ontology/imports/cl_import.owl @@ -9,12 +9,13 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" + xmlns:terms="http://purl.org/dc/terms/" xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2022-01-19 + + + 2022-08-03 @@ -88,6 +89,18 @@ + + + + + + + + + + + + @@ -134,6 +147,14 @@ + + + + + + + + @@ -152,14 +173,7 @@ - - http://purl.org/dc/elements/1.1/contributor - uberon - dc-contributor - true - dc-contributor - contributor - + @@ -175,12 +189,31 @@ + + + + http://purl.org/dc/terms/contributor + uberon + dc-contributor + true + dc-contributor + contributor + + + + + + + + + + @@ -231,9 +264,7 @@ - - has_obo_namespace - + @@ -277,9 +308,13 @@ - - shorthand - + + + + + + + @@ -392,13 +427,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. CALOHA:TS-2035 + FBbt:00007002 FMA:68646 GO:0005623 KUPO:0000002 + MESH:D002477 VHOG:0001533 WBbt:0004017 XAO:0003012 - cell The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). cell @@ -419,7 +455,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment). CARO:0000013 cell in vivo - cell To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). native cell @@ -439,7 +474,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An neuronal receptor cell (sensu Animalia) - cell neuronal receptor cell @@ -450,7 +484,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - cell migratory cranial neural crest cell @@ -468,7 +501,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. - cell migratory trunk neural crest cell @@ -485,13 +517,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - Male germ cell is a germ cell that supports male gamete production. + A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis. FMA:72290 MA:0002765 VHOG:0001531 ncithesaurus:Spermatogenic_Cell - cell male germ cell + https://github.com/obophenotype/cell-ontology/issues/574 @@ -502,7 +534,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - Male germ cell is a germ cell that supports male gamete production. + A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis. + PMID:29462262 https://orcid.org/0000-0001-5208-3432 @@ -525,7 +558,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00004936 FMA:84049 WBbt:0006799 - cell spermatocyte @@ -539,7 +571,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids. GOC:tfm - MESH:A05.360.490.890.880 + MESH:D013090 @@ -563,7 +595,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72294 WBbt:0006800 nematoblast - cell spermatid @@ -576,7 +607,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa. - MESH:A05.360.490.890.860 + MESH:D013087 @@ -601,7 +632,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An sperm cell spermatozoid spermatozoon - cell sperm @@ -615,7 +645,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mature male germ cell that develops from a spermatid. GOC:tfm - MESH:A05.360.490.890 + MESH:D013094 @@ -628,17 +658,17 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000958 CALOHA:TS-2193 EMAPA:31482 + FBbt:00004934 FBbt:00004935 FMA:72291 spermatogonial cell - cell spermatogonium An euploid male germ cell of an early stage of spermatogenesis. - MESH:A05.360.490.890.900 + MESH:D013093 @@ -651,7 +681,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000388 VHOG:0001530 ncithesaurus:Egg - cell female germ cell @@ -681,8 +710,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0711 FBbt:00004886 FMA:18644 + MESH:D009865 WBbt:0006797 - cell oogonium oocyte @@ -719,9 +748,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00057012 FMA:67343 MA:0000388 + MESH:D010063 mature oocyte ovum - cell egg cell @@ -751,7 +780,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An neuron neural crest derived - cell neural crest derived neuron @@ -773,8 +801,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt:00005145 - cell glioblast @@ -790,7 +816,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000930 FMA:70563 neuroblast - cell neuroblast (sensu Vertebrata) @@ -806,12 +831,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. CALOHA:TS-2086 FMA:63368 animal stem cell - cell This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. stem cell @@ -820,7 +845,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. GOC:tfm - MESH:A11.872 + MESH:D013234 @@ -833,7 +858,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:70569 unipotent stem cell unipotential stem cell - cell single fate stem cell @@ -849,7 +873,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell + epithelial stem cell epithelial fate stem cell @@ -872,11 +896,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0448 FMA:70337 FMA:86475 + MESH:D006412 VHOG:0001485 HSC blood forming stem cell hemopoietic stem cell - cell colony forming unit hematopoietic Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. hematopoietic stem cell @@ -907,7 +931,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A progenitor cell committed to the erythroid lineage. BTO:0004911 - cell BFU-E CFU-E blast forming unit erythroid @@ -937,7 +960,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. - cell Originally this term had some plant germ line cell children. germ line cell @@ -966,7 +988,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. CALOHA:TS-1195 FMA:83553 - cell CFU-M colony forming unit macrophage colony forming unit monocyte @@ -996,6 +1017,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + @@ -1008,7 +1030,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:86684 NSC neural stem cell - cell neuronal stem cell @@ -1040,7 +1061,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An multifate stem cell multipotent cell multipotent stem cell - cell multi fate stem cell @@ -1060,7 +1080,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0004730 CMP common myeloid precursor - cell CFU-GEMM CFU-S colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte @@ -1081,50 +1100,50 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. GOC:add - ISBN:0878932437 + ISBN:0878932437 MESH:D023461 CMP - ISBN:0878932437 + ISBN:0878932437 CFU-GEMM - ISBN:0878932437 + ISBN:0878932437 CFU-S - ISBN:0878932437 + ISBN:0878932437 colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte - ISBN:0878932437 + ISBN:0878932437 multipotential myeloid stem cell - ISBN:0878932437 + ISBN:0878932437 myeloid stem cell - ISBN:0878932437 + ISBN:0878932437 pluripotent stem cell (bone marrow) - ISBN:0878932437 + ISBN:0878932437 @@ -1143,7 +1162,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An colony forming unit erythroid megakaryocyte megakaryocyte/erythrocyte progenitor megakaryocyte/erythroid progenitor cell - cell MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. megakaryocyte-erythroid progenitor cell @@ -1178,7 +1196,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor - cell ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -1214,7 +1231,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000125 FMA:84782 blast cell - cell define using PATO mulit-potent or oligopotent? non-terminally differentiated cell @@ -1237,7 +1253,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00005083 FMA:70335 VHOG:0001529 - cell myoblast @@ -1245,7 +1260,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. GOC:tfm - MESH:A11.635 + MESH:D032446 PMID:21849021 @@ -1266,7 +1281,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0362 FMA:63877 VHOG:0001482 - cell These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. fibroblast @@ -1275,7 +1289,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. ISBN:0517223651 - MESH:A11.329.228 MESH:D005347 http://en.wikipedia.org/wiki/Fibroblast @@ -1297,7 +1310,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003607 FMA:66783 chrondoplast - cell chondroblast @@ -1330,7 +1342,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:70576 amelocyte enamel secreting cell - cell non-encoded relationship from VSAO produces VSAO:0000066 ameloblast @@ -1340,7 +1351,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell. GOC:tfm GO_REF:0000034 - MESH:A11.436.107 + MESH:D000565 @@ -1361,7 +1372,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001593 CALOHA:TS-0720 FMA:66780 - cell non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 osteoblast @@ -1370,7 +1380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell. GO_REF:0000034 - MESH:A11.329.629 + MESH:D010006 @@ -1382,7 +1392,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that has a filiform extrusion of the cell surface. VHOG:0001532 XAO:0000031 - cell ciliated cell @@ -1406,7 +1415,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:66768 WBbt:0003672 epitheliocyte - cell epithelial cell @@ -1415,7 +1423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. FB:ma GOC:tfm - MESH:A11.436 + MESH:D004847 @@ -1427,7 +1435,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell that has a cilia. FMA:70605 - cell ciliated epithelial cell @@ -1445,7 +1452,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell that is part of a duct. - cell duct epithelial cell @@ -1461,7 +1467,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell branched duct epithelial cell @@ -1480,7 +1485,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An endothelial cell that lines the vasculature. cuboidal endothelial cell of vascular tree - cell blood vessel endothelial cell @@ -1503,7 +1507,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell non-branched duct epithelial cell @@ -1515,7 +1518,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. - cell columnar/cuboidal epithelial cell @@ -1533,7 +1535,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-1249 - cell squamous epithelial cell @@ -1548,7 +1549,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A flattened epithelial cell of mesenchymal origin that lines the serous cavity. FMA:66773 mesotheliocyte - cell mesothelial cell @@ -1572,7 +1572,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell stratified epithelial cell @@ -1584,7 +1583,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell found predominately in the blood. FMA:62844 - cell + MESH:D001773 blood cell @@ -1610,7 +1609,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell of the lung. BTO:0004299 lung epithelial cell - cell epithelial cell of lung @@ -1637,7 +1635,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000028 pancreas epithelial cell pancreatic epithelial cell - cell epithelial cell of pancreas @@ -1671,11 +1668,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000782 CALOHA:TS-1001 FMA:62870 + MESH:D013601 VHOG:0001479 T lymphocyte T-cell T-lymphocyte - cell immature T cell mature T cell T cell @@ -1710,7 +1707,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An macrophagocytus stellatus stellate cell of von Kupffer von Kupffer cell - cell Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. Kupffer cell @@ -1728,7 +1724,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:tfm GO_REF:0000031 ISBN:0517223651 - MESH:A11.329.372.588 + MESH:D007728 PMID:15771589 PMID:17105582 @@ -1750,7 +1746,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000968 CALOHA:TS-0721 FMA:66781 - cell + MESH:D010010 chondroclast Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. osteoclast @@ -1776,8 +1772,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO_REF:0000031 ISBN:0781735149 PMID:10428500 - PMID:15055519 - PMID:17380158 + PMID:15055519 + PMID:17380158 @@ -1795,7 +1791,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An granular leucocyte granular leukocyte polymorphonuclear leukocyte - cell granulocyte @@ -1810,7 +1805,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A leukocyte with abundant granules in the cytoplasm. GOC:amm GOC:tfm - MESH:A11.118.637.415 MESH:D006098 http://en.wikipedia.org/wiki/Granulocyte @@ -1827,7 +1821,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell neuron associated cell @@ -1851,7 +1844,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An histaminocyte labrocyte mastocyte - cell tissue basophil Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. mast cell @@ -1869,8 +1861,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:add GOC:dsd GOC:tfm - ISBN:068340007X - MESH:A11.329.427 + ISBN:068340007X MESH:D008407 PMCID:PMC1312421 PMCID:PMC2855166 @@ -1896,7 +1887,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tissue basophil - ISBN:068340007X + ISBN:068340007X @@ -1910,7 +1901,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. neuroepithelial cell BTO:0004301 - cell The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). sensory epithelial cell @@ -1934,7 +1924,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00005125 FMA:67313 WBbt:0005113 - cell interneuron @@ -1942,7 +1931,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. GOC:tfm - MESH:A08.663.358 + MESH:D007395 @@ -1953,17 +1942,17 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. BTO:0000312 + FBbt:00005123 FMA:83617 WBbt:0005409 motoneuron - cell motor neuron An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. - MESH:A08.663.655.500 + MESH:D009046 PMID:16875686 @@ -1977,8 +1966,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001037 FBbt:00005124 FMA:84649 + MESH:D011984 WBbt:0005759 - cell sensory neuron @@ -1996,7 +1985,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body. FMA:67282 - cell bipolar neuron @@ -2014,16 +2002,15 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - Neuron with an axon and two or more dendrites. + A neuron with three or more neurites, usually an axon and multiple dendrites. FMA:67287 - cell multipolar neuron - Neuron with an axon and two or more dendrites. + A neuron with three or more neurites, usually an axon and multiple dendrites. FMA:67287 GOC:tfm @@ -2036,7 +2023,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron whose cell body is within an autonomic ganglion. FMA:80121 - cell autonomic neuron @@ -2056,8 +2042,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron that uses acetylcholine as a vesicular neurotransmitter. BTO:0004902 FMA:84796 + MESH:D059329 WBbt:0006840 - cell cholinergic neuron @@ -2073,7 +2059,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell + MESH:D059331 adrenergic neuron @@ -2083,7 +2069,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell peptidergic neuron @@ -2096,7 +2081,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vertebrate phagocyte with a single nucleus. BTO:0001433 - cell mononuclear phagocyte @@ -2123,7 +2107,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72552 cell of surface ectoderm surface ectoderm cell - cell surface ectodermal cell @@ -2139,7 +2122,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0278 FMA:66772 endotheliocyte - cell From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. endothelial cell @@ -2166,7 +2148,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell CNS neuron (sensu Vertebrata) @@ -2175,13 +2156,15 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004. + MESH:D000080906 Golgi cell Golgi neuron cerebellar Golgi neuron cerebellum Golgi cell - cell cerebellar Golgi cell @@ -2198,7 +2181,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003393 - cell granule cell @@ -2218,14 +2200,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Purkinje's cell cerebellar Purkinje cell cerebellum Purkinje cell - cell Purkinje cell The output neuron of the cerebellar cortex. - MESH:A08.186.211.132.810.428.200.212.600 + MESH:D011689 @@ -2240,7 +2221,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell neuron associated cell (sensu Vertebrata) @@ -2250,37 +2230,21 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. BTO:0002606 CALOHA:TS-0415 + FBbt:00005144 FMA:54536 neuroglial cell - cell neuroglia + Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 glial cell - - - - - - - - - - It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation. - A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. - MESH:A08.637 + MESH:D009457 @@ -2300,7 +2264,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-2027 FMA:54538 macrogliocyte - cell macroglial cell @@ -2322,7 +2285,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0060 FMA:54537 astrocytic glia - cell Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. astrocyte @@ -2332,7 +2294,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. GOC:dsd GOC:tfm - MESH:A08.637.200 MESH:D001253 PMID:11746784 PMID:12162730 @@ -2347,6 +2308,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + @@ -2358,7 +2320,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0709 FMA:54540 OLs - cell oligodendroglia Oligodendrocytes are reportedly MDP-positive and CD4-negative. oligodendrocyte @@ -2373,7 +2334,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system. - MESH:A08.637.600 MESH:D009836 http://en.wikipedia.org/wiki/Oligodendrocyte @@ -2394,7 +2354,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. @@ -2407,9 +2367,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hortega cells microglia microgliocyte - cell MF.microglia.CNS - Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. + Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. microglial cell @@ -2426,7 +2385,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PMID:14561199 PMID:14612429 PMID:16177057 - PMID:19461673 + PMID:19461673 PMID:2089275 http://en.wikipedia.org/wiki/Microglia @@ -2442,6 +2401,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An microgliocyte http://www.copewithcytokines.de/ + + + + Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. + PMID:23616747 + @@ -2451,7 +2416,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Ectoderm destined to be nervous tissue. neurectoderm cell - cell neurectodermal cell @@ -2459,7 +2423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Ectoderm destined to be nervous tissue. GOC:tfm - ISBN:068340007X + ISBN:068340007X @@ -2478,7 +2442,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells - cell CFU-F MSC mesenchymal precursor cell @@ -2504,7 +2467,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FB:ma GOC:dsd PMCID:PMC2613570 - PMID:10102814j + PMID:10102814 PMID:16923606 PMID:17986482 PMID:19960544 @@ -2558,7 +2521,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes. FMA:63879 - cell Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. fibrocyte @@ -2579,7 +2541,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PMID:11641248 PMID:15010326 PMID:17607298 - PMID:18222966 + PMID:18222966 PMID:8790603 PMID:9551999 http://en.wikipedia.org/wiki/Fibrocyte @@ -2605,14 +2567,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:63880 adipocyte adipose cell - cell fat cell A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. - MESH:A11.329.114 + MESH:D017667 @@ -2633,7 +2594,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-1167 FMA:66779 VSAO:0000124 - cell VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 osteocyte @@ -2642,7 +2602,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. GOC:tfm - MESH:A11.329.629.500 + MESH:D010011 @@ -2663,7 +2623,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0138 FMA:66782 cartilage cell - cell chondrocyte @@ -2671,7 +2630,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. GO_REF:0000034 - MESH:A11.329.171 + MESH:D019902 @@ -2682,7 +2641,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. APC - cell Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -2700,7 +2658,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell simple columnar epithelial cell @@ -2714,7 +2671,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001678 chromatocyte chromatophore - cell pigment cell @@ -2742,9 +2698,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000847 CALOHA:TS-0613 FMA:70545 + MESH:D008544 VHOG:0001679 melanophore - cell melanocyte @@ -2771,7 +2727,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. CALOHA:TS-2085 FMA:86494 - cell glandular epithelial cell @@ -2790,7 +2745,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that specializes in controlled release of one or more substances. BTO:0003659 FMA:86916 - cell secretory cell @@ -2809,7 +2763,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. FMA:16014 - cell exocrine cell @@ -2829,7 +2782,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that secretes glycosaminoglycans. GAG secreting cell hyaluronic acid secreting cell - cell glycosaminoglycan secreting cell @@ -2845,7 +2797,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell protein secreting cell @@ -2862,7 +2813,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gastric chief cell pepsinogen secreting cell zymogenic cell - cell peptic cell @@ -2879,7 +2829,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that specializes in secretion of surfactant in the alveoli of the lung. - cell surfactant secreting cell @@ -2909,7 +2858,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Clara cell bronchiolar non-ciliated cell club cell of bronchiole - cell club cell @@ -2935,7 +2883,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell seromucus secreting cell @@ -2951,14 +2898,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:13148 http://en.wikipedia.org/wiki/Goblet_cell chalice cell - cell goblet cell A cell of the epithelial lining that produce and secrete mucins. - MESH:A03.492.411.369.320 + MESH:D020397 @@ -2967,7 +2913,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell acid secreting cell @@ -2988,7 +2933,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001780 FMA:62901 oxyntic cell - cell parietal cell @@ -3008,14 +2952,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. FMA:83809 endocrinocyte - cell endocrine cell A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. - MESH:A06.407 + MESH:D055098 @@ -3028,7 +2971,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. BTO:0003865 FMA:62930 - cell + MESH:D019858 enteroendocrine cell @@ -3051,14 +2994,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0002691 FMA:83810 neurosecretory cell - cell neuroendocrine cell An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals. - MESH:A06.688 + MESH:D055099 @@ -3077,14 +3019,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000259 FMA:69263 phaeochromocyte - cell chromaffin cell A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system. - MESH:A06.224.161 + MESH:D019439 @@ -3093,7 +3034,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell peptide hormone secreting cell @@ -3105,7 +3045,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000783 - cell insulin secreting cell @@ -3139,7 +3078,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pancreatic beta cell pancreatic islet core type B enteroendocrine cell - cell beta cell islet Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. type B pancreatic cell @@ -3228,7 +3166,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that secretes glucagon. FMA:84045 glucagon-secreting cell - cell glucagon secreting cell @@ -3255,9 +3192,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. BTO:0000990 FMA:70585 + MESH:D050416 alpha cell of islet of Langerhans pancreatic alpha cell - cell pancreatic A cell @@ -3274,7 +3211,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell somatostatin secreting cell @@ -3301,14 +3237,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pancreatic D-cell pancreatic delta cell somatostatin-secreting pancreatic cell - cell pancreatic D cell A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. - FMA:0517223651 + FMA:0517223651 GOC:tfm @@ -3318,7 +3253,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell steroid hormone secreting cell @@ -3328,7 +3262,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell testosterone secreting cell @@ -3338,14 +3271,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. interstitial cell BTO:0000755 CALOHA:TS-1150 EMAPA:29655 FMA:72297 + MESH:D007985 interstitial cell of Leydig - cell Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated Leydig cell @@ -3375,7 +3314,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000575 CALOHA:TS-0454 FMA:14515 - cell Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. hepatocyte @@ -3385,7 +3323,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. GOC:tfm ISBN:0412046911 - MESH:A11.436.348 + MESH:D022781 PMID:19717280 http://en.wikipedia.org/wiki/Hepatocyte @@ -3397,7 +3335,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose primary function is to shorten. - cell contractile cell @@ -3421,7 +3358,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:67799 basket epithelial cell myoepitheliocyte - cell myoepithelial cell @@ -3456,14 +3392,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An WBbt:0003675 muscle fiber myocyte - cell muscle cell A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. - MESH:A11.620 + MESH:D032342 @@ -3477,7 +3412,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-2158 FMA:9727 skeletal muscle cell - cell cell of skeletal muscle @@ -3501,7 +3435,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A muscle cell that develops tension more slowly than a fast-twitch fiber. FMA:84448 - cell slow muscle fiber slow muscle cell @@ -3531,15 +3464,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron . + A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron. glycolytic muscle fiber - cell fast muscle cell - A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron . + A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron. GOC:tfm ISBN:0323052908 @@ -3566,14 +3498,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SMCs myocytes, smooth muscle smooth muscle fiber - cell smooth muscle cell A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). - MESH:A11.620.520 MESH:D032389 PMID:9315361 http://en.wikipedia.org/wiki/Smooth_muscle_cell @@ -3598,8 +3528,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is capable of detection of a stimulus involved in sensory perception. + MESH:D011984 receptor cell - cell sensory receptor cell @@ -3612,7 +3542,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings. nociceptor nocireceptor - cell Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship pain receptor cell @@ -3620,7 +3549,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings. - MESH:A08.800.550.700.650 + MESH:D009619 @@ -3630,7 +3559,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. - cell mechanoreceptor mechanoreceptor cell @@ -3638,7 +3566,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. - MESH:A08.800.550.700.500 + MESH:D008465 @@ -3656,7 +3584,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. CL:0000201 FMA:62364 - cell auditory receptor cell In mammals these cells are located in the organ of Corti. auditory hair cell @@ -3665,7 +3592,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. - MESH:A08.663.650.250 + MESH:D006198 WikipediaVersioned:Hair_cell&oldid=1045345915 @@ -3676,7 +3603,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain. - cell thermoreceptor cell @@ -3684,7 +3610,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain. GOC:tfm - MESH:A08.800.550.700.840 + MESH:D013823 MP:0000971 @@ -3695,14 +3621,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. - cell chemoreceptor cell A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. - MESH:A08.800.550.700.120 + MESH:D002628 @@ -3714,12 +3639,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0004185 FMA:67860 + MESH:D018034 Wikipedia:Olfactory_receptor_neuron Schultze's cell odorant receptor cell olfactory receptor neuron olfactory sensory neuron - cell olfactory receptor cell @@ -3732,9 +3657,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell specialized to detect and transduce light. BTO:0001060 CALOHA:TS-0868 - FBbt:00004211 FMA:86740 - cell photoreceptor cell @@ -3747,7 +3670,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell specialized to detect and transduce light. - MESH:A08.663.650.650 + MESH:D010786 @@ -3757,7 +3680,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose function is determined by the generation or the reception of an electric signal. - cell electrically active cell @@ -3774,7 +3696,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that takes up and metabolizes substances. - cell absorptive cell @@ -3792,7 +3713,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. boundary cell - cell lining cell @@ -3809,7 +3729,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose primary function is to prevent the transport of stuff across compartments. - cell barrier cell @@ -3832,7 +3751,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0922 FMA:72298 VHOG:0001348 - cell Sertoli cell @@ -3845,7 +3763,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier. - MESH:A05.360.444.849.789 + MESH:D012708 @@ -3854,7 +3772,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell insulating cell @@ -3864,8 +3781,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + @@ -3878,7 +3795,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0898 FMA:62121 neurilemmal cell - cell myelinating Schwann cell @@ -3887,7 +3803,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons. GOC:cvs GOC:tfm - MESH:A08.637.800 + MESH:D012583 @@ -3897,7 +3813,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that moves by its own activities. - cell motile cell @@ -3916,14 +3831,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell of the outer of the three germ layers of the embryo. FMA:72549 ectoderm cell - cell ectodermal cell A cell of the outer of the three germ layers of the embryo. - MESH:A16.254.425.273 + MESH:D004475 @@ -3936,14 +3850,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72554 mesoblast mesoderm cell - cell mesodermal cell A cell of the middle germ layer of the embryo. - MESH:A16.254.425.660 + MESH:D008648 @@ -3955,14 +3868,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell of the inner of the three germ layers of the embryo. FMA:72555 endoderm cell - cell endodermal cell A cell of the inner of the three germ layers of the embryo. - MESH:A16.254.425.407 + MESH:D004707 @@ -3974,7 +3886,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that lacks a nucleus. FMA:68647 non-nucleated cell - cell anucleate cell @@ -3991,7 +3902,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell with a single nucleus. - cell single nucleate cell @@ -4014,7 +3924,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An syncitium syncytial cell syncytium - cell multinucleate cell @@ -4044,7 +3953,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:81100 RBC red blood cell - cell erythrocyte @@ -4058,7 +3966,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. GOC:tfm - MESH:A11.118.290 + MESH:D004912 @@ -4083,7 +3991,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anucleate thrombocyte blood platelet enucleate thrombocyte - cell Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. platelet @@ -4100,7 +4007,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:add GOC:dsd GOC:tfm - MESH:A11.118.188 MESH:D001792 PMID:11110672 PMID:16987572 @@ -4121,7 +4027,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any cell capable of ingesting particulate matter via phagocytosis. BTO:0001044 FMA:83806 - cell + MESH:D010586 phagocyte @@ -4151,8 +4057,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0587 FMA:63261 FMA:83585 + MESH:D008264 histiocyte - cell Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. macrophage @@ -4183,11 +4089,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000776 CALOHA:TS-0068 FMA:62869 + MESH:D001402 VHOG:0001480 B lymphocyte B-cell B-lymphocyte - cell B cell @@ -4220,7 +4126,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell keratinizing barrier epithelial cell @@ -4231,7 +4136,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell brush border epithelial cell @@ -4242,7 +4146,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell stratified squamous epithelial cell @@ -4257,7 +4160,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. FMA:70548 Merkel's cell - cell Merkel cell @@ -4270,7 +4172,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. - MESH:A08.800.550.700.500.425 + MESH:D018862 @@ -4279,7 +4181,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell + MESH:D005057 eukaryotic cell @@ -4289,7 +4191,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell eye photoreceptor cell @@ -4303,7 +4204,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CL:0000471 growth hormone secreting cell somatotrophin secreting cell - cell somatotropin secreting cell @@ -4326,7 +4226,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00005412 FMA:18649 haploid nucleated cell - cell haploid germ cell gamete @@ -4350,9 +4249,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt:00004193 lens cell - cell crystallin accumulating cell @@ -4362,7 +4259,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell keratin accumulating cell @@ -4380,7 +4276,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62879 keratinized cell of epidermis malpighian cell - cell Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. keratinocyte @@ -4401,12 +4296,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. GOC:dsd - MESH:A11.436.397 - MESH:D015603 - PMID:15582983 - PMID:15749908 - PMID:19727116 - http://en.wikipedia.org/wiki/Keratinocyte + MESH:D015603 + PMID:15582983 + PMID:15749908 + PMID:19727116 + http://en.wikipedia.org/wiki/Keratinocyte @@ -4418,14 +4312,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris. sebocyte - cell sebum secreting cell A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris. - MESH:A12.200.702 + MESH:D012629 @@ -4436,7 +4329,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003689 mucous cell - cell mucus secreting cell @@ -4452,7 +4344,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62499 alveolar epithelial cell pneumonocyte - cell pneumocyte @@ -4460,7 +4351,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. GOC:tfm - PMID:20054144 + PMID:20054144 @@ -4469,7 +4360,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell lysozyme secreting cell @@ -4480,7 +4370,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is specialised to accumulate a particular substance(s). - cell stuff accumulating cell @@ -4497,7 +4386,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell glycogen accumulating cell @@ -4506,29 +4394,16 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - cell extracellular matrix secreting cell - - - - - cell - myelin accumulating cell - - - - - cell oxygen accumulating cell @@ -4548,7 +4423,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. FMA:86667 - cell migratory neural crest cell @@ -4575,7 +4449,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CL:1000422 FMA:69262 medullary chromaffin cell of adrenal gland - cell adrenal medulla chromaffin cell @@ -4603,7 +4476,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An early neural cell developing from the early ependymal cell of the neural tube. FMA:70564 spongioblast - cell glioblast (sensu Vertebrata) @@ -4621,7 +4493,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell extraembryonic cell @@ -4634,7 +4505,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. FMA:83028 trophoblastic cell - cell trophoblast cell @@ -4648,7 +4518,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. GOC:tfm - MESH:A11.936 + MESH:D014327 @@ -4660,7 +4530,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. FMA:86767 - cell Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. multi-potent skeletal muscle stem cell @@ -4683,7 +4552,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell stratified epithelial stem cell @@ -4698,9 +4566,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001470 CALOHA:TS-0283 FMA:62411 + MESH:D000078404 cell of epidermis epithelial cell of skin - cell epidermal cell @@ -4708,7 +4576,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell of the integument (the outer layer of an organism). Flybase:dsj - MA:ma + MA:ma @@ -4731,7 +4599,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00005130 - cell neurosecretory neuron @@ -4742,7 +4609,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose function is determined by its response to an electric signal. - cell electrically responsive cell @@ -4760,7 +4626,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell CNS interneuron @@ -4777,7 +4642,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that initiates an electrical signal and passes that signal to another cell. - cell electrically signaling cell @@ -4796,7 +4660,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001277 CALOHA:TS-0949 - cell male gamete @@ -4819,7 +4682,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose nucleus, or nuclei, each contain more than two haploid genomes. - cell polyploid cell @@ -4836,7 +4698,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose nucleus contains a single haploid genome. - cell haploid cell @@ -4853,7 +4714,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell endopolyploid cell @@ -4865,7 +4725,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids. WBbt:0005812 - cell excretory cell @@ -4873,7 +4732,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids. GOC:tfm - PMID:19783135 + PMID:19783135 @@ -4893,7 +4752,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gonadotroph gonadotropic cell pituitary delta cell - cell gonadtroph @@ -4912,7 +4770,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A peptide hormone secreting cell pituitary that produces luteinizing hormone. - cell luteinizing hormone secreting cell @@ -4929,7 +4786,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A peptide hormone cell that secretes prolactin. - cell prolactin secreting cell @@ -4950,7 +4806,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0002277 melanotrope melanotroph - cell melanocyte stimulating hormone secreting cell @@ -4967,7 +4822,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00004903 - cell follicle stem cell @@ -4980,7 +4834,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. BTO:0004267 FMA:83037 - cell + MESH:D020566 Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. follicular dendritic cell @@ -4997,7 +4851,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell calcitonin secreting cell @@ -5016,7 +4869,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An parathyroid gland chief cell parathyroid hormone secreting cell principal cell of parathyroid gland - cell chief cell of parathyroid gland @@ -5034,7 +4886,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell carbohydrate secreting cell @@ -5055,7 +4906,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83434 white adipose cell white fat cell - cell white adipocyte white fat cell @@ -5064,7 +4914,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole. GOC:tfm - MESH:A11.329.114.500 + MESH:D052438 @@ -5084,14 +4934,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83435 brown adipocyte brown adipose cell - cell brown fat cell A cell from the thermogenic form of adipose tissue found in many species, particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation. - MESH:A10.165.114.322 + MESH:D002001 @@ -5105,7 +4954,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0002042 CALOHA:TS-0194 FMA:83036 - cell + MESH:D003713 interdigitating cell veiled cell dendritic cell @@ -5124,7 +4973,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell thyroid hormone secreting cell @@ -5145,9 +4993,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000705 CALOHA:TS-2375 FMA:63072 + MESH:D007801 LC Langerhans' cell - cell Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. Langerhans cell @@ -5179,7 +5027,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types. adrenaline secreting cell epinephrin secreting cell - cell epinephrine secreting cell @@ -5202,7 +5049,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell biogenic amine secreting cell @@ -5215,7 +5061,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell type that secretes 5-Hydroxytryptamine (serotonin). 5-HT secreting cell 5-Hydroxytryptamine secreting cell - cell serotonin secreting cell @@ -5236,7 +5081,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An noradrenaline secreting cell norepinephrin secreting cell norepinephrine secreting cell - cell noradrenergic cell @@ -5244,7 +5088,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. GOC:tfm - ISBN:068340007X + ISBN:068340007X @@ -5261,7 +5105,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An corticotrophin hormone secreting cell corticotropin hormone secreting cell corticotropin secreting cell - cell adrenocorticotropic hormone secreting cell @@ -5275,13 +5118,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ACTH secreting cell - GO:0051458 + GO:0051458 corticotropin secreting cell - GO:0051458 + GO:0051458 @@ -5291,7 +5134,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose primary function is to protect the organism. - cell defensive cell @@ -5309,10 +5151,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center. FMA:83099 + MESH:D052684 beta-basophil thyroid stimulating hormone secreting cell thyrotrope - cell thyrotroph @@ -5328,6 +5170,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + @@ -5335,12 +5178,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A somatic epithelial cell of the ovarian follicle/egg chamber. + A somatic epithelial cell of the insect egg chamber. follicle cell + ovarian follicle cell FBbt:00004904 - cell - Editors note: check this. Currently used in goxp - ovarian follicle cell + follicle cell of egg chamber @@ -5362,7 +5204,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CD4-positive helper T lymphocyte CD4-positive helper T-cell CD4-positive helper T-lymphocyte - cell CD4-positive helper T cell @@ -5380,7 +5221,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:tfm GO_REF:0000031 ISBN:0781735149 - MESH:A11.118.637.555.567.569.200.400 + MESH:D006377 @@ -5391,7 +5232,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS). FMA:84776 - cell inhibitory interneuron @@ -5417,7 +5257,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. BTO:0002064 FMA:83624 - cell stromal cell @@ -5425,11 +5264,22 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. GOC:tfm - MESH:A11.329.830 + MESH:D017154 + + + + + + An epithelial somatic cell associated with a maturing oocyte. + follicular epithelial cell + + + + @@ -5440,14 +5290,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0729 FMA:18718 granulosa cell of ovary - cell granulosa cell A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors. - MESH:A05.360.319.114.630.535.200 + MESH:D006107 @@ -5460,14 +5309,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. FMA:62935 D cell - cell type D enteroendocrine cell A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. - MESH:A03.492.766.440.175 + MESH:D019864 @@ -5480,14 +5328,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells. BTO:0002850 FMA:18690 - cell theca cell A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells. - MESH:A05.360.319.114.630.535.400 + MESH:D013799 @@ -5501,7 +5348,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. BTO:0000993 FMA:62897 - cell paneth cell @@ -5516,7 +5362,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. GOC:tfm ISBN:0517223651 - MESH:A03.492.411.369.700 + MESH:D019879 @@ -5526,7 +5372,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A peptide hormone secreting cell that secretes androgen binding protein. - cell androgen binding protein secreting cell @@ -5548,7 +5393,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:84797 cardiac muscle progenitor cell cardiomyocyte progenitor cell - cell cardiac muscle myoblast @@ -5556,7 +5400,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A precursor cell destined to differentiate into cardiac muscle cell. GOC:tfm - MESH:A11.635.470 + MESH:D032386 @@ -5568,7 +5412,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A precursor cell destined to differentiate into smooth muscle myocytes. FMA:84798 myoblast, smooth muscle - cell satellite cell smooth muscle myoblast @@ -5583,7 +5426,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A precursor cell destined to differentiate into smooth muscle myocytes. GOC:tfm - MESH:A11.635.510 MESH:D032390 @@ -5609,7 +5451,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A myoblast that differentiates into skeletal muscle fibers. FMA:84799 skeletal myoblast - cell skeletal muscle myoblast @@ -5638,7 +5479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. - cell + lipophage macrophage derived foam cell @@ -5657,7 +5498,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A phagocyte in vertebrates that is able to phagocytosis. - cell phagocyte (sensu Vertebrata) @@ -5679,7 +5519,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An plasmidotrophoblast syncytial trophoblast syntrophoblast - cell syncytiotrophoblast cell @@ -5699,7 +5538,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron which conveys sensory information centrally from the periphery. FMA:87653 input neuron - cell afferent neuron @@ -5707,7 +5545,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron which conveys sensory information centrally from the periphery. GOC:tfm - MESH:A08.663.650 + MESH:D009475 @@ -5718,14 +5556,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron which sends impulses peripherally to activate muscles or secretory cells. output neuron - cell efferent neuron A neuron which sends impulses peripherally to activate muscles or secretory cells. - MESH:A08.663.655 + MESH:D009476 @@ -5734,7 +5571,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell pigmented epithelial cell @@ -5754,7 +5590,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001483 WBbt:0003679 nerve cell - cell These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron @@ -5762,7 +5597,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. - MESH:A08.663 MESH:D009474 http://en.wikipedia.org/wiki/Neuron @@ -5784,7 +5618,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that originates from the neural crest and differentiates into a pigment cell. BTO:0003217 FMA:83377 - cell Derived from UBERON:0002342 neural crest. melanoblast @@ -5812,8 +5645,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000775 CALOHA:TS-0583 FMA:62863 + MESH:D008214 VHOG:0001535 - cell Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) lymphocyte @@ -5844,7 +5677,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Th1 T-lymphocyte Th1 cell helper T cell type 1 - cell This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells. T-helper 1 cell @@ -5862,8 +5694,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:pam GOC:tfm GO_REF:0000031 - PMID:19375293 - PMID:20303875 + PMID:19375293 + PMID:20303875 PMID:22343568 @@ -5889,6 +5721,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4. BTO:0001679 FMA:84385 + MESH:D018418 T helper cells type 2 T(H)-2 cell Th2 T cell @@ -5897,7 +5730,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Th2 T-lymphocyte Th2 cell helper T cell type 2 - cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell. T-helper 2 cell @@ -5915,7 +5747,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:pam GOC:tfm GO_REF:0000031 - PMID:19375293 + PMID:19375293 PMID:20103781 PMID:22343568 @@ -5942,7 +5774,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. FMA:83518 rubriblast - cell pronormoblast proerythroblast @@ -5973,7 +5804,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell animal cell @@ -5990,7 +5820,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An early erythroblast early normoblast prorubricyte - cell basophilic erythroblast @@ -6051,7 +5880,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An polychromatic normoblast polychromatophilic normoblast rubricyte - cell polychromatophilic erythroblast @@ -6122,7 +5950,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An late erythoblast orthochromatic normoblast pyknotic eto enrythroblast - cell orthochromatic erythroblast @@ -6179,6 +6006,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001164 CALOHA:TS-0610 FMA:84235 + MESH:D055016 CFU-Meg Meg-CFC MkP @@ -6187,7 +6015,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An megacaryocyte progenitor cell megakaryoblast megakaryocytic progenitor cell - cell promegacaryocyte promegakaryocyte Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. @@ -6253,7 +6080,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An megacaryocyte megalocaryocyte megalokaryocyte - cell Megakaryocytes are reportedly CD181-positive and CD182-positive. megakaryocyte @@ -6289,7 +6115,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor - cell Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -6303,8 +6128,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO_REF:0000031 ISBN:0721601464 MESH:D055014 - PMCID:PMC2213186 - PMCID:PMC548021 + PMCID:PMC2213186 + PMCID:PMC548021 PMID:16551251 PMID:16647566 http://en.wikipedia.org/wiki/CFU-GM @@ -6321,32 +6146,32 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CFU-GM ISBN:0721601464 - PMCID:PMC2213186 - PMCID:PMC548021 + PMCID:PMC2213186 + PMCID:PMC548021 GMP ISBN:0721601464 - PMCID:PMC2213186 - PMCID:PMC548021 + PMCID:PMC2213186 + PMCID:PMC548021 colony forming unit granulocyte macrophage ISBN:0721601464 - PMCID:PMC2213186 - PMCID:PMC548021 + PMCID:PMC2213186 + PMCID:PMC548021 granulocyte-macrophage progenitor ISBN:0721601464 - PMCID:PMC2213186 - PMCID:PMC548021 + PMCID:PMC2213186 + PMCID:PMC548021 @@ -6364,7 +6189,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. BTO:0001173 CALOHA:TS-0864 - cell + MESH:D012156 reticulocyte @@ -6399,7 +6224,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. BTO:0004657 FMA:83551 - cell Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. promonocyte @@ -6428,7 +6252,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0004044 FMA:67766 amacrine neuron - cell amacrine cell @@ -6436,8 +6259,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons. GOC:tfm - MESH:A08.663.358.050 - WikipediaVersioned:Amacrine_cell&oldid=1023572246 + MESH:D025042 + WikipediaVersioned:Amacrine_cell&oldid=1023572246 @@ -6456,7 +6279,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mesenchymal stem cell capable of developing into blood vessel endothelium. angioblast chondroplast - cell These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. angioblastic mesenchymal cell @@ -6481,7 +6303,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - cell polymodal nocireceptor @@ -6495,7 +6316,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003866 FMA:83114 APUD cell - cell amine precursor uptake and decarboxylation cell @@ -6529,7 +6349,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An clear cell of thyroid gland parafollicular cell of thyroid gland thyroid parafollicular cell - cell parafollicular cell @@ -6592,14 +6411,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001036 CALOHA:TS-0866 FMA:67748 - cell retinal cone cell One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. - MESH:A08.663.650.650.670.100 + MESH:D017949 @@ -6620,7 +6438,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000876 CALOHA:TS-0638 FMA:62864 - cell Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. monocyte @@ -6635,7 +6452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. GO_REF:0000031 - MESH:A11.118.637.555.652 + MESH:D009000 @@ -6647,7 +6464,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive. BTO:0001034 FMA:83025 - cell Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. peritoneal macrophage @@ -6661,7 +6477,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive. - MESH:A11.329.372.630 + MESH:D017737 PMID:15771589 PMID:19201820 @@ -6678,7 +6494,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0030 FMA:83023 dust cell - cell MF.Lu Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. alveolar macrophage @@ -6697,7 +6512,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GOC:dsd GOC:tfm GO_REF:0000031 - MESH:A11.329.372.600 + MESH:D016676 @@ -6711,7 +6526,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen. BTO:0000398 FMA:62122 - cell + MESH:D020895 + differentiated enterocyte + mature enterocyte enterocyte @@ -6720,6 +6537,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen. SANBI:mhl + + + + differentiated enterocyte + PMID:33290721 + https://orcid.org/0000-0001-9610-7627 + + + + + mature enterocyte + PMID:33290721 + https://orcid.org/0000-0001-9610-7627 + @@ -6731,7 +6562,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000535 VHOG:0001534 WBbt:0006796 - cell germ cell @@ -6744,7 +6574,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The reproductive cell in multicellular organisms. - MESH:A05.360.490 + MESH:D005854 @@ -6757,14 +6587,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An inner hair cell BTO:0003667 FMA:62365 - cell cochlear inner hair cell A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated. - MESH:A08.663.650.250.250 + MESH:D006199 @@ -6774,7 +6603,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A steroid hormone secreting cell that secretes androgen. - cell androgen secreting cell @@ -6792,7 +6620,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers. - cell Skeletal muscle satellite cells are not traditionally referred to as myoblasts. They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population. skeletal muscle satellite cell @@ -6801,7 +6628,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers. GOC:tfm - MESH:A11.635.500.700 + MESH:D032496 PMID:21849021 PMID:23303905 @@ -6822,7 +6649,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An erythrocyte lacking a nucleus. RBC red blood cell - cell enucleate erythrocyte @@ -6853,7 +6679,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An projection neuron pyramidal cell pyramidal neuron - cell pyramidal neuron @@ -6862,7 +6687,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala. GOC:tfm - MESH:A08.186.211.577.405.700 + MESH:D017966 @@ -6874,14 +6699,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea. BTO:0003666 FMA:62366 - cell cochlear outer hair cell A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea. - MESH:A08.663.650.250.315 + MESH:D018072 @@ -6891,14 +6715,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls. - cell pressoreceptor cell A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls. - MESH:A08.800.050.800.900.700 + MESH:D011311 @@ -6917,14 +6740,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001024 CALOHA:TS-0870 FMA:67747 - cell retinal rod cell One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. - MESH:A08.663.650.650.670.650 + MESH:D017948 @@ -6936,7 +6758,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. FMA:62351 vestibular receptor cell - cell vestibular hair cell @@ -6944,7 +6765,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. GOC:tfm - MESH:A08.663.650.250.380 + MESH:D018069 @@ -6956,9 +6777,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A neuron that uses GABA as a vesicular neurotransmitter FMA:84788 + MESH:D059330 WBbt:0005190 GABA-ergic neuron - cell GABAergic neuron @@ -6977,9 +6798,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). FMA:83625 + MESH:D061354 acinic cell acinous cell - cell acinar cell @@ -7010,9 +6831,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-0664 FMA:63147 FMA:83601 + MESH:D007694 VHOG:0001697 NK cell - cell natural killer cell @@ -7034,7 +6855,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CD4-positive, alpha-beta T lymphocyte CD4-positive, alpha-beta T-cell CD4-positive, alpha-beta T-lymphocyte - cell CD4-positive, alpha-beta T cell @@ -7061,7 +6881,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CD8-positive, alpha-beta T lymphocyte CD8-positive, alpha-beta T-cell CD8-positive, alpha-beta T-lymphocyte - cell CD8-positive, alpha-beta T cell @@ -7088,7 +6907,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell whose primary function is to support other cell types. BTO:0002315 supportive cell - cell supporting cell @@ -7105,7 +6923,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. BTO:0002741 @@ -7114,7 +6931,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Ito cell hepatic perisinusoidal cell perisinusoidal cell - cell fat-storing cell lipocyte vitamin A-storing cells @@ -7126,18 +6942,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. GOC:dsd - MESH:D055166 - PMID:12808230 - PMID:17239632 - PMID:18222966 - PMID:9302568 - http://en.wikipedia.org/wiki/Hepatic_stellate_cell + MESH:D055166 + PMID:12808230 + PMID:17239632 + PMID:18222966 + PMID:9302568 + http://en.wikipedia.org/wiki/Hepatic_stellate_cell vitamin A-storing cells - PMID:12808230 + PMID:12808230 @@ -7151,7 +6967,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Hensen's cell cell of Hensen external limiting cell of organ of Corti - cell Hensen cell @@ -7172,7 +6987,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:79802 cell of Claudius external supporting cell of vestibular epithelium - cell external supporting cell of Claudius Claudius cell @@ -7194,7 +7008,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:75725 Deiters cell outer phalangeal cell - cell Deiter's cell @@ -7217,7 +7030,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003064 Muller glia Müller cell - cell Mueller cell @@ -7240,7 +7052,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell that stains readily in the anterior pituitary gland. FMA:83089 - cell chromophil cell of anterior pituitary gland @@ -7260,7 +7071,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A basophillic chromophil cell that of the anterior pituitary gland. FMA:83094 basophil cell of anterior lobe of hypophysis - cell beta cell pituitary beta cell basophil cell of pars distalis of adenohypophysis @@ -7280,7 +7090,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones. - cell folliculostellate cell @@ -7300,7 +7109,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:54559 Bergmann astrocyte Bergmann glial cell of cerebellum - cell Bergmann glial cell @@ -7316,19 +7124,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. + + + A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. BTO:0003793 FMA:83503 - cell pituicyte - A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. + A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment. ISBN:0412046911 ISBN:0517223651 + PMID:31915267 http://en.wikipedia.org/wiki/Pituicyte @@ -7341,7 +7150,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament. BTO:0000939 FMA:62516 - cell basal cell @@ -7366,7 +7174,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:84138 JG cell renin secreting cell - cell kidney granular cell @@ -7388,7 +7195,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CL:0002186 FMA:69059 prickle cell of epidermis - cell prickle cell @@ -7416,8 +7222,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000853 CALOHA:TS-0617 FMA:70972 + MESH:D050527 kidney mesangial cell - cell Do all of these cells really develop from some mesenchymal stem cell? mesangial cell @@ -7438,7 +7244,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands neck cell - cell mucous neck cell @@ -7459,7 +7264,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation. BTO:0001068 FMA:83417 - cell pinealocyte @@ -7479,33 +7283,36 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. + A specialized kidney epithelial cell, contained within a glomerulus, that contains "feet" that interdigitate with the "feet" of other podocytes. + http://orcid.org/0000-0002-1773-2692 epithelial cell of visceral layer of glomerular capsule BTO:0002295 - FMA:70967 + FMA:70967 glomerular podocyte - podocyte - cell - GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. - glomerular visceral epithelial cell + glomerular visceral epithelial cell + kidney podocyte + renal podocyte + podocyte + https://github.com/obophenotype/cell-ontology/issues/1460 - A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. + A specialized kidney epithelial cell, contained within a glomerulus, that contains "feet" that interdigitate with the "feet" of other podocytes. GOC:tfm + https://doi.org/10.1101/2021.10.10.463829 epithelial cell of visceral layer of glomerular capsule - FMA:70967 + FMA:70967 glomerular podocyte - FMA:70967 + FMA:70967 @@ -7518,7 +7325,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001115 CALOHA:TS-2194 FMA:72292 - cell primary spermatocyte @@ -7553,7 +7359,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-2195 FBbt:00004941 FMA:72293 - cell secondary spermatocyte @@ -7577,7 +7382,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An extracellular matrix secreting cell that secretes collagen. - cell collagen secreting cell @@ -7603,12 +7407,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ARC adventitial reticular cell cell of Rouget - pericyte + pericyte cell pericyte of Rouget - cell adventitial cell Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. - pericyte cell + pericyte @@ -7620,7 +7423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MESH:D020286 PMID:16807374 PMID:17986482 - PMID:20024907 + PMID:20024907 @@ -7640,7 +7443,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:70567 gonocyte primitive germ cell - cell primordial germ cell @@ -7671,7 +7473,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mature sexual reproductive cell of the female germline. - cell female gamete @@ -7694,7 +7495,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules. - cell gut absorptive cell @@ -7712,7 +7512,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An WBbt:0006829 - cell glutamatergic neuron @@ -7730,7 +7529,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A non-terminally differentiated cell that is capable of developing into a muscle cell. - cell muscle precursor cell @@ -7754,7 +7552,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration. forebrain radial glial cell - cell Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. radial glial cell @@ -7777,7 +7574,6 @@ radial glial cells acting as neural progenitors throughout life. https://orcid.org/0000-0001-7258-9596 CR cells Horizontal cells of Cajal - cell While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity. Cajal-Retzius cell @@ -7785,26 +7581,26 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the human embryonic marginal zone which display, as a salient feature, radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. One feature of these cells in mammals is that they express the Reelin gene. - PMID:10600995 + PMID:10600995 PMID:9728912 CR cells - WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753 + WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753 Horizontal cells of Cajal - WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753 + WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753 While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity. - PMID:10600995 + PMID:10600995 @@ -7818,7 +7614,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:62938 FMA:83409 type F enteroendocrine cell - cell PP cell @@ -7840,9 +7635,9 @@ radial glial cells acting as neural progenitors throughout life. A neuron that releases dopamine as a neurotransmitter. BTO:0004032 FMA:84787 + MESH:D059290 WBbt:0006746 dopaminergic cell - cell dopaminergic neuron @@ -7869,7 +7664,6 @@ radial glial cells acting as neural progenitors throughout life. neuroepithelial cell BTO:0004301 FMA:70557 - cell The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). neurecto-epithelial cell @@ -7890,7 +7684,7 @@ radial glial cells acting as neural progenitors throughout life. A stem cell that can give rise to cell types of the body other than those of the germ-line. CALOHA:TS-2086 FMA:63368 - cell + MESH:D053687 somatic stem cell @@ -7916,7 +7710,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0002916 CALOHA:TS-2157 FMA:86936 - cell striated muscle cell @@ -7945,10 +7738,10 @@ radial glial cells acting as neural progenitors throughout life. BTO:0000751 CALOHA:TS-0549 FMA:62852 + MESH:D007962 immune cell leucocyte white blood cell - cell leukocyte @@ -7975,10 +7768,10 @@ radial glial cells acting as neural progenitors throughout life. The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. BTO:0001800 FMA:67765 + MESH:D012165 RGC gangliocyte ganglion cell of retina - cell retinal ganglion cell @@ -7998,7 +7791,6 @@ radial glial cells acting as neural progenitors throughout life. A neuron that laterally connects other neurons in the inner nuclear layer of the retina. BTO:0004120 horizontal cell - cell retina horizontal cell @@ -8027,11 +7819,11 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001539 CALOHA:TS-0115 FMA:14067 + MESH:D032383 cardiac muscle fiber cardiac myocyte cardiomyocyte heart muscle cell - cell This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. cardiac muscle cell @@ -8060,7 +7852,6 @@ radial glial cells acting as neural progenitors throughout life. - A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer. retinal bipolar neuron @@ -8080,7 +7871,6 @@ radial glial cells acting as neural progenitors throughout life. A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light. FMA:67750 - cell rod bipolar cell @@ -8098,7 +7888,6 @@ radial glial cells acting as neural progenitors throughout life. A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer. - cell cone retinal bipolar cell @@ -8122,7 +7911,6 @@ radial glial cells acting as neural progenitors throughout life. A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates. - cell Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. nucleated thrombocyte @@ -8156,7 +7944,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. BTO:0001441 CALOHA:TS-0647 - cell + MESH:D022423 myeloid cell @@ -8184,7 +7972,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:62845 FMA:83516 erythropoietic cell - cell Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. erythroid lineage cell @@ -8213,8 +8000,8 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001571 CALOHA:TS-0289 FMA:83504 + MESH:D004900 normoblast - cell erythroblast @@ -8240,7 +8027,6 @@ radial glial cells acting as neural progenitors throughout life. A cell of the monocyte, granulocyte, or mast cell lineage. - cell myeloid leukocyte @@ -8270,7 +8056,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:62862 basophilic leucocyte basophilic leukocyte - cell Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. basophil @@ -8289,12 +8074,12 @@ radial glial cells acting as neural progenitors throughout life. GOC:dsd GOC:tfm ISBN:0721601464 - MESH:D001491 + MESH:D001491 PMCID:PMC2626675 - PMID:11927641 - PMID:19741522 - PMID:21236338 - PMID:9933081 + PMID:11927641 + PMID:19741522 + PMID:21236338 + PMID:9933081 @@ -8309,11 +8094,11 @@ radial glial cells acting as neural progenitors throughout life. BTO:0000399 CALOHA:TS-0279 FMA:62861 + MESH:D004804 eosinocyte eosinophilic granulocyte eosinophilic leucocyte eosinophilic leukocyte - cell Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. eosinophil @@ -8333,8 +8118,8 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm ISBN:0721601464 PMCID:PMC2626675 - PMID:10914487 - PMID:1662676 + PMID:10914487 + PMID:1662676 @@ -8354,12 +8139,12 @@ radial glial cells acting as neural progenitors throughout life. BTO:0000130 CALOHA:TS-0688 FMA:62860 + MESH:D009504 neutrocyte neutrophil leucocyte neutrophil leukocyte neutrophilic leucocyte neutrophilic leukocyte - cell neutrophil @@ -8397,7 +8182,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0004721 CD11c+CD123- DC mDC - cell These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). myeloid dendritic cell @@ -8413,8 +8197,8 @@ radial glial cells acting as neural progenitors throughout life. A dendritic cell of the myeloid lineage. GOC:add PMID:10449155 - PMID:17332250 - PMID:9521319 + PMID:17332250 + PMID:9521319 @@ -8425,7 +8209,6 @@ radial glial cells acting as neural progenitors throughout life. A phagocyte formed by the fusion of mononuclear phagocytes. - cell multinucleated phagocyte @@ -8459,7 +8242,6 @@ radial glial cells acting as neural progenitors throughout life. plasmacytoid T cell plasmacytoid monocyte type 2 DC - cell plasmacytoid dendritic cell @@ -8477,7 +8259,7 @@ radial glial cells acting as neural progenitors throughout life. PMCID:PMC2118448 PMCID:PMC538703 PMID:15549123 - PMID:17332250 + PMID:17332250 PMID:17850486 PMID:20304825 @@ -8499,7 +8281,6 @@ radial glial cells acting as neural progenitors throughout life. mature B lymphocyte mature B-cell mature B-lymphocyte - cell Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. mature B cell @@ -8533,11 +8314,11 @@ radial glial cells acting as neural progenitors throughout life. A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. BTO:0000392 FMA:70574 + MESH:D010950 plasma B cell plasma B-cell plasmacyte plasmocyte - cell effector B cell effector B-cell Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. @@ -8559,7 +8340,7 @@ radial glial cells acting as neural progenitors throughout life. ISBN:0721601464 ISBN:0781735149 PMID:19447676 - PMID:20081059 + PMID:20081059 PMID:20839338 PMID:20951740 http://en.wikipedia.org/wiki/Plasma_cell @@ -8575,7 +8356,6 @@ radial glial cells acting as neural progenitors throughout life. memory B lymphocyte memory B-cell memory B-lymphocyte - cell Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. memory B cell @@ -8594,7 +8374,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:rhs GO_REF:0000031 ISBN:0781735149 - PMID:20081059 + PMID:20081059 PMID:20839338 http://en.wikipedia.org/wiki/Memory_B_cell @@ -8609,7 +8389,6 @@ radial glial cells acting as neural progenitors throughout life. naive B lymphocyte naive B-cell naive B-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. naive B cell @@ -8629,7 +8408,7 @@ radial glial cells acting as neural progenitors throughout life. GO_REF:0000031 ISBN:0781765196 PMID:19447676 - PMID:20081059 + PMID:20081059 PMID:20839338 PMID:20933013 PMID:22343568 @@ -8645,7 +8424,6 @@ radial glial cells acting as neural progenitors throughout life. alpha-beta T lymphocyte alpha-beta T-cell alpha-beta T-lymphocyte - cell alpha-beta T cell @@ -8674,7 +8452,6 @@ radial glial cells acting as neural progenitors throughout life. immature alpha-beta T lymphocyte immature alpha-beta T-cell immature alpha-beta T-lymphocyte - cell immature alpha-beta T cell @@ -8709,7 +8486,6 @@ radial glial cells acting as neural progenitors throughout life. mature alpha-beta T lymphocyte mature alpha-beta T-cell mature alpha-beta T-lymphocyte - cell mature alpha-beta T cell @@ -8743,7 +8519,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte CD4-positive, CD25-positive, alpha-beta regulatory T-cell CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. CD4-positive, CD25-positive, alpha-beta regulatory T cell @@ -8789,7 +8564,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta intraepithelial T lymphocyte CD4-positive, alpha-beta intraepithelial T-cell CD4-positive, alpha-beta intraepithelial T-lymphocyte - cell CD4-positive, alpha-beta intraepithelial T cell @@ -8833,7 +8607,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta cytotoxic T lymphocyte CD8-positive, alpha-beta cytotoxic T-cell CD8-positive, alpha-beta cytotoxic T-lymphocyte - cell Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. CD8-positive, alpha-beta cytotoxic T cell @@ -8875,7 +8648,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta regulatory T lymphocyte CD8-positive, alpha-beta regulatory T-cell CD8-positive, alpha-beta regulatory T-lymphocyte - cell CD8-positive, alpha-beta regulatory T cell @@ -8905,7 +8677,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta intraepithelial T lymphocyte CD8-positive, alpha-beta intraepithelial T-cell CD8-positive, alpha-beta intraepithelial T-lymphocyte - cell CD8-alpha-beta-positive, alpha-beta intraepithelial T cell @@ -8935,7 +8706,6 @@ radial glial cells acting as neural progenitors throughout life. alpha-beta intraepithelial T lymphocyte alpha-beta intraepithelial T-cell alpha-beta intraepithelial T-lymphocyte - cell alpha-beta intraepithelial T cell @@ -8964,7 +8734,6 @@ radial glial cells acting as neural progenitors throughout life. gamma-delta T-cell gamma-delta T-lymphocyte gammadelta T cell - cell gd T cell Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. gamma-delta T cell @@ -9001,7 +8770,6 @@ radial glial cells acting as neural progenitors throughout life. immature gamma-delta T lymphocyte immature gamma-delta T-cell immature gamma-delta T-lymphocyte - cell Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. immature gamma-delta T cell @@ -9036,7 +8804,6 @@ radial glial cells acting as neural progenitors throughout life. mature gamma-delta T lymphocyte mature gamma-delta T-cell mature gamma-delta T-lymphocyte - cell mature gamma-delta T cell @@ -9067,7 +8834,6 @@ radial glial cells acting as neural progenitors throughout life. gamma-delta intraepithelial T lymphocyte gamma-delta intraepithelial T-cell gamma-delta intraepithelial T-lymphocyte - cell gamma-delta intraepithelial T cell @@ -9097,7 +8863,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, gamma-delta intraepithelial T lymphocyte CD8-positive, gamma-delta intraepithelial T-cell CD8-positive, gamma-delta intraepithelial T-lymphocyte - cell CD8-alpha alpha positive, gamma-delta intraepithelial T cell @@ -9127,7 +8892,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, gamma-delta intraepithelial T lymphocyte CD4-positive, gamma-delta intraepithelial T-cell CD4-positive, gamma-delta intraepithelial T-lymphocyte - cell CD4-negative CD8-negative gamma-delta intraepithelial T cell @@ -9163,7 +8927,6 @@ radial glial cells acting as neural progenitors throughout life. immature single positive T cell immature single positive T lymphocyte immature single positive T-lymphocyte - cell Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. immature single positive thymocyte @@ -9206,7 +8969,6 @@ radial glial cells acting as neural progenitors throughout life. TN2 thymocyte double negative 2 preT.DN2.Th - cell Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. DN2 thymocyte @@ -9243,7 +9005,6 @@ radial glial cells acting as neural progenitors throughout life. TN3 thymocyte double negative 3 preT.DN3.Th - cell There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. DN3 thymocyte @@ -9278,7 +9039,6 @@ radial glial cells acting as neural progenitors throughout life. DN4 immature T-cell T.DN4.th double negative 4 - cell Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'. DN4 thymocyte @@ -9310,7 +9070,6 @@ radial glial cells acting as neural progenitors throughout life. DP cell DP thymocyte double-positive, alpha-beta immature T lymphocyte - cell Thymocytes of this stage are undergoing positive and negative selection. double-positive, alpha-beta thymocyte @@ -9348,7 +9107,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta immature T-cell CD4-positive, alpha-beta immature T-lymphocyte SP CD4 cell - cell CD4-positive, alpha-beta thymocyte @@ -9385,7 +9143,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta immature T-cell CD8-positive, alpha-beta immature T-lymphocyte SP CD8 cell - cell CD8-positive, alpha-beta immature T cell CD8-positive, alpha-beta thymocyte @@ -9416,7 +9173,6 @@ radial glial cells acting as neural progenitors throughout life. memory T lymphocyte memory T-cell memory T-lymphocyte - cell memory T cell @@ -9457,7 +9213,6 @@ radial glial cells acting as neural progenitors throughout life. mature natural killer T lymphocyte mature natural killer T-cell mature natural killer T-lymphocyte - cell mature NK T cell @@ -9487,11 +9242,11 @@ radial glial cells acting as neural progenitors throughout life. suppressor T-lymphocyte BTO:0004520 FMA:84070 + MESH:D050378 Treg regulatory T lymphocyte regulatory T-cell regulatory T-lymphocyte - cell This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. regulatory T cell @@ -9526,7 +9281,6 @@ radial glial cells acting as neural progenitors throughout life. immature B-cell immature B-lymphocyte newly formed B cell - cell Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. immature B cell @@ -9540,7 +9294,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm GO_REF:0000031 ISBN:0781735149 - PMID:20081059 + PMID:20081059 PMID:20839338 @@ -9559,7 +9313,6 @@ radial glial cells acting as neural progenitors throughout life. A precursor B cell is a B cell with the phenotype CD10-positive. BTO:0001133 CALOHA:TS-0819 - cell pre-B cell precursor B cell @@ -9598,7 +9351,6 @@ radial glial cells acting as neural progenitors throughout life. T1 B cell T2 B cell T3 B cell - cell This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'. transitional stage B cell @@ -9641,7 +9393,6 @@ radial glial cells acting as neural progenitors throughout life. B1 B-cell B1 B-lymphocyte B1 cell - cell There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. B-1 B cell @@ -9658,7 +9409,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:dsd GO_REF:0000031 - PMID:11861604 + PMID:11861604 PMID:20933013 PMID:21220451 http://en.wikipedia.org/wiki/B-1_cell @@ -9682,7 +9433,6 @@ radial glial cells acting as neural progenitors throughout life. CD5(+) B1 cell CD5+ B1 cell CD5-positive B1 cell - cell B-1a B cell @@ -9696,7 +9446,7 @@ radial glial cells acting as neural progenitors throughout life. A B-1 B cell that has the phenotype CD5-positive. GOC:add - PMID:11861604 + PMID:11861604 @@ -9714,7 +9464,6 @@ radial glial cells acting as neural progenitors throughout life. B1b B-cell B1b B-lymphocyte B1b cell - cell B-1b B cell @@ -9728,7 +9477,7 @@ radial glial cells acting as neural progenitors throughout life. A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell. GOC:add - PMID:11861604 + PMID:11861604 @@ -9746,7 +9495,6 @@ radial glial cells acting as neural progenitors throughout life. B2 B-cell B2 B-lymphocyte B2 cell - cell B-0 B cell B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. B-2 B cell @@ -9765,7 +9513,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:dsd GOC:tfm ISBN:0781735149 - PMID:11861604 + PMID:11861604 PMID:20933013 @@ -9784,7 +9532,6 @@ radial glial cells acting as neural progenitors throughout life. A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR). immature NK cell - cell p-NK In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. immature natural killer cell @@ -9821,7 +9568,6 @@ radial glial cells acting as neural progenitors throughout life. LAK cell lymphokine activated killer cell mature NK cell - cell mature natural killer cell @@ -9862,7 +9608,6 @@ radial glial cells acting as neural progenitors throughout life. NKP natural killer cell progenitor pro-natural killer cell - cell null cell preNK cell Most markers only described for human pro NK cells. @@ -9881,30 +9626,30 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:pam GO_REF:0000031 - PMID:11532393 + PMID:11532393 PMID:12457618 - PMID:15032583 - PMID:15766674 + PMID:15032583 + PMID:15766674 NKP PMID:12457618 - PMID:15032583 - PMID:15766674 + PMID:15032583 + PMID:15766674 null cell - PMID:11532393 + PMID:11532393 preNK cell - PMID:11532393 + PMID:11532393 @@ -9929,7 +9674,6 @@ radial glial cells acting as neural progenitors throughout life. progenitor B lymphocyte progenitor B-cell progenitor B-lymphocyte - cell pre-B cell (Philadelphia nomenclature) Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. pro-B cell @@ -9947,7 +9691,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:dsd ISBN:0781735149 - PMID:12633665 + PMID:12633665 PMID:16551251 PMID:18432934 @@ -9955,7 +9699,7 @@ radial glial cells acting as neural progenitors throughout life. pre-pro B cell - PMID:17582343 + PMID:17582343 @@ -9982,7 +9726,6 @@ radial glial cells acting as neural progenitors throughout life. DN1 cell DN1 thymocyte TN1 cell - cell pro-T cell @@ -10014,7 +9757,6 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates. - cell Note that this is a non-mammalian cell type. thromboblast @@ -10030,7 +9772,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates. GOC:add GOC:tfm - PMID:7758949 + PMID:7758949 @@ -10048,7 +9790,6 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative. MCP - cell CFU-MC CFU-Mast colony forming unit mast cell @@ -10090,7 +9831,6 @@ radial glial cells acting as neural progenitors throughout life. The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. BTO:0000187 FMA:83524 - cell myeloblast @@ -10126,7 +9866,6 @@ radial glial cells acting as neural progenitors throughout life. CALOHA:TS-0448 MPP hemopoietic progenitor cell - cell Markers differ between mouse and human. hematopoietic multipotent progenitor cell @@ -10151,7 +9890,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0004731 CALOHA:TS-2025 FMA:70338 - cell Note that this is a class of cell types, not an identified single cell type. lymphoid lineage restricted progenitor cell @@ -10181,7 +9919,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0004730 CALOHA:TS-2099 FMA:70339 - cell Note that this is a class of cell types, not an identified single cell type. myeloid lineage restricted progenitor cell @@ -10213,7 +9950,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:86713 mononuclear leukocyte peripheral blood mononuclear cell - cell mononuclear cell @@ -10241,7 +9977,6 @@ radial glial cells acting as neural progenitors throughout life. follicular B lymphocyte follicular B-cell follicular B-lymphocyte - cell Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. follicular B cell @@ -10254,7 +9989,7 @@ radial glial cells acting as neural progenitors throughout life. ISBN:0781735149 PMCID:PMC2193793 PMID:20933013 - http://en.wikipedia.org/wiki/Follicular_B_Cells + http://en.wikipedia.org/wiki/Follicular_B_Cells @@ -10277,7 +10012,6 @@ radial glial cells acting as neural progenitors throughout life. germinal center B lymphocyte germinal center B-cell germinal center B-lymphocyte - cell Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. germinal center B cell @@ -10317,7 +10051,6 @@ radial glial cells acting as neural progenitors throughout life. marginal zone B-lymphocyte B cell of marginal zone of spleen marginal zone of spleen B cell - cell MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. marginal zone B cell of spleen @@ -10347,7 +10080,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings. - cell vestibular dark cell @@ -10366,11 +10098,10 @@ radial glial cells acting as neural progenitors throughout life. A neuron that releases serotonin as a neurotransmitter. CL:0000403 - FBbt:00005133 + MESH:D059326 WBbt:0006837 5-HT neuron 5-hydroxytryptamine neuron - cell serotinergic neuron serotonergic neuron @@ -10390,7 +10121,6 @@ radial glial cells acting as neural progenitors throughout life. Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. hair cell BTO:0004744 - cell sensory hair cell @@ -10407,7 +10137,6 @@ radial glial cells acting as neural progenitors throughout life. A skeletal muscle myoblast that differentiates into slow muscle fibers. - cell slow muscle myoblast @@ -10424,7 +10153,6 @@ radial glial cells acting as neural progenitors throughout life. A skeletal muscle myoblast that differentiates into fast muscle fibers. - cell fast muscle myoblast @@ -10445,7 +10173,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:84644 fixed macrophage resting histiocyte - cell tissue-resident macrophage @@ -10470,7 +10197,6 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage found in a secondary lymphoid organ. - cell secondary lymphoid organ macrophage @@ -10491,7 +10217,6 @@ radial glial cells acting as neural progenitors throughout life. A secondary lymphoid organ macrophage found in the spleen. FMA:83026 - cell Role or process: immune, clearance of apoptotic and senescent cells. splenic macrophage @@ -10507,7 +10232,7 @@ radial glial cells acting as neural progenitors throughout life. A secondary lymphoid organ macrophage found in the spleen. GO_REF:0000031 PMID:15771589 - PMID:16322748 + PMID:16322748 @@ -10517,7 +10242,6 @@ radial glial cells acting as neural progenitors throughout life. A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive. - cell Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. splenic marginal zone macrophage @@ -10545,7 +10269,6 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage found in the central nervous system. CNS macrophage - cell central nervous system macrophage @@ -10559,7 +10282,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage found in the central nervous system. GO_REF:0000031 - PMID:16322748 + PMID:16322748 @@ -10569,7 +10292,6 @@ radial glial cells acting as neural progenitors throughout life. A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+. - cell Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. perivascular macrophage @@ -10597,7 +10319,7 @@ radial glial cells acting as neural progenitors throughout life. A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions. BTO:0003872 FMA:83586 - cell + MESH:D005487 foam cell @@ -10621,9 +10343,9 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001372 CALOHA:TS-1042 FMA:72202 + MESH:D060168 XAO:0003159 thymic lymphocyte - cell thymocyte @@ -10662,7 +10384,6 @@ radial glial cells acting as neural progenitors throughout life. DN1 thymocyte double negative 1 preT.DN1.Th - cell DN1 thymic pro-T cell @@ -10700,7 +10421,6 @@ radial glial cells acting as neural progenitors throughout life. naive thymus-derived CD4-positive, alpha-beta T lymphocyte naive thymus-derived CD4-positive, alpha-beta T-cell naive thymus-derived CD4-positive, alpha-beta T-lymphocyte - cell These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells. naive thymus-derived CD4-positive, alpha-beta T cell @@ -10750,7 +10470,6 @@ radial glial cells acting as neural progenitors throughout life. activated CD4-positive, alpha-beta T lymphocyte activated CD4-positive, alpha-beta T-cell activated CD4-positive, alpha-beta T-lymphocyte - cell activated CD4-positive, alpha-beta T cell @@ -10780,7 +10499,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta memory T lymphocyte CD4-positive, alpha-beta memory T-cell CD4-positive, alpha-beta memory T-lymphocyte - cell T4.Mem.Sp CD4-positive, alpha-beta memory T cell @@ -10803,7 +10521,6 @@ radial glial cells acting as neural progenitors throughout life. naive T lymphocyte naive T-cell naive T-lymphocyte - cell naive T cell @@ -10830,6 +10547,7 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17. + MESH:D058504 IL-17-producing CD4+ T helper T helper cells type 17 T(H)-17 cell @@ -10840,7 +10558,6 @@ radial glial cells acting as neural progenitors throughout life. Th17 T-lymphocyte Th17 cell helper T cell type 17 - cell This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells. T-helper 17 cell @@ -10857,7 +10574,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:pam GO_REF:0000031 - PMID:20303875 + PMID:20303875 PMID:20969597 PMID:22343568 @@ -10887,7 +10604,6 @@ radial glial cells acting as neural progenitors throughout life. naive thymus-dervied CD8-positive, alpha-beta T-cell naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte T.8Nve.Sp - cell This cell traffics in secondary lymphoid organs and blood. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells. naive thymus-derived CD8-positive, alpha-beta T cell @@ -10930,7 +10646,6 @@ radial glial cells acting as neural progenitors throughout life. central memory CD4-positive, alpha-beta T lymphocyte central memory CD4-positive, alpha-beta T-cell central memory CD4-positive, alpha-beta T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells. central memory CD4-positive, alpha-beta T cell @@ -10971,7 +10686,6 @@ radial glial cells acting as neural progenitors throughout life. effector memory CD4-positive, alpha-beta T lymphocyte effector memory CD4-positive, alpha-beta T-cell effector memory CD4-positive, alpha-beta T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells. effector memory CD4-positive, alpha-beta T cell @@ -11014,7 +10728,6 @@ radial glial cells acting as neural progenitors throughout life. activated CD8-positive, alpha-beta T lymphocyte activated CD8-positive, alpha-beta T-cell activated CD8-positive, alpha-beta T-lymphocyte - cell activated CD8-positive, alpha-beta T cell @@ -11048,7 +10761,6 @@ radial glial cells acting as neural progenitors throughout life. central memory CD8-positive, alpha-beta T lymphocyte central memory CD8-positive, alpha-beta T-cell central memory CD8-positive, alpha-beta T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells. central memory CD8-positive, alpha-beta T cell @@ -11066,7 +10778,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:pam GOC:tfm GO_REF:0000031 - PMID:20146720 + PMID:20146720 PMID:22343568 @@ -11092,7 +10804,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta cytokine secreting effector T lymphocyte CD8-positive, alpha-beta cytokine secreting effector T-cell CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte - cell CD8-positive, alpha-beta cytokine secreting effector T cell @@ -11109,7 +10820,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:pam GOC:tfm GO_REF:0000031 - PMID:20146720 + PMID:20146720 @@ -11124,7 +10835,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta memory T lymphocyte CD8-positive, alpha-beta memory T-cell CD8-positive, alpha-beta memory T-lymphocyte - cell T.8Mem.Sp CD8-positive, alpha-beta memory T cell @@ -11133,7 +10843,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell. GOC:add - PMID:20146720 + PMID:20146720 @@ -11149,7 +10859,6 @@ radial glial cells acting as neural progenitors throughout life. cytotoxic T lymphocyte cytotoxic T-cell cytotoxic T-lymphocyte - cell cytotoxic T cell @@ -11179,7 +10888,6 @@ radial glial cells acting as neural progenitors throughout life. effector T lymphocyte effector T-cell effector T-lymphocyte - cell effector T cell @@ -11206,11 +10914,11 @@ radial glial cells acting as neural progenitors throughout life. A effector T cell that provides help in the form of secreted cytokines to other immune cells. BTO:0002417 + MESH:D006377 T-helper cell helper T lymphocyte helper T-cell helper T-lymphocyte - cell helper T cell @@ -11245,7 +10953,6 @@ radial glial cells acting as neural progenitors throughout life. effector memory CD8-positive, alpha-beta T lymphocyte effector memory CD8-positive, alpha-beta T-cell effector memory CD8-positive, alpha-beta T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells. effector memory CD8-positive, alpha-beta T cell @@ -11262,7 +10969,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:pam GO_REF:0000031 - PMID:20146720 + PMID:20146720 PMID:22343568 @@ -11289,7 +10996,6 @@ radial glial cells acting as neural progenitors throughout life. immature NK T-cell immature NK T-lymphocyte immature NKT cell - cell immature NK T cell @@ -11306,7 +11012,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:pam GOC:tfm GO_REF:0000031 - PMID:17589542 + PMID:17589542 PMID:19169262 @@ -11327,7 +11033,6 @@ radial glial cells acting as neural progenitors throughout life. dendritic epidermal T lymphocyte dendritic epidermal T-cell dendritic epidermal T-lymphocyte - cell In mice, DETC have an invariant T cell receptor. dendritic epidermal T cell @@ -11371,7 +11076,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte CD8-positive, CD25-positive, alpha-beta regulatory T-cell CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte - cell CD8-positive, CD25-positive, alpha-beta regulatory T cell @@ -11401,7 +11105,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte - cell CD4-negative, CD8-negative, alpha-beta intraepithelial T cell @@ -11428,7 +11131,6 @@ radial glial cells acting as neural progenitors throughout life. Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins. pre-NK cell - cell These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. pre-natural killer cell @@ -11458,7 +11160,6 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte of B lineage with the commitment to express an immunoglobulin complex. - cell Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). lymphocyte of B lineage @@ -11486,7 +11187,6 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin. - cell antibody secreting cell @@ -11514,7 +11214,6 @@ radial glial cells acting as neural progenitors throughout life. A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes. small pre-BII cell - cell Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. small pre-B-II cell @@ -11534,7 +11233,7 @@ radial glial cells acting as neural progenitors throughout life. GO_REF:0000031 PMID:16551251 PMID:18432934 - PMID:9785673 + PMID:9785673 @@ -11548,7 +11247,6 @@ radial glial cells acting as neural progenitors throughout life. CALOHA:TS-0819 pre-B-lymphocyte pre-BII cell - cell pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. pre-B-II cell @@ -11566,7 +11264,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:rhs GOC:tfm GO_REF:0000031 - PMID:9785673 + PMID:9785673 @@ -11580,7 +11278,6 @@ radial glial cells acting as neural progenitors throughout life. T1 B-cell T1 B-lymphocyte transitional stage 1 B cell - cell T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. T1 B cell @@ -11619,7 +11316,6 @@ radial glial cells acting as neural progenitors throughout life. T2 B-cell T2 B-lymphocyte transitional stage 2 B cell - cell T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. T2 B cell @@ -11659,7 +11355,6 @@ radial glial cells acting as neural progenitors throughout life. T3 B-cell T3 B-lymphocyte transitional stage 3 B cell - cell T3 B cell @@ -11676,14 +11371,14 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm GO_REF:0000031 PMID:12810111 - PMID:17174121 + PMID:17174121 http://www.immgen.org/index_content.html An1 B cell - PMID:17174121 + PMID:17174121 @@ -11699,7 +11394,6 @@ radial glial cells acting as neural progenitors throughout life. A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow. - cell long lived plasma cell @@ -11716,7 +11410,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm GO_REF:0000031 ISBN:9780781765190 - PMID:16014527 + PMID:16014527 @@ -11726,7 +11420,6 @@ radial glial cells acting as neural progenitors throughout life. A fully differentiated plasma cell that lives for months. - cell short lived plasma cell @@ -11741,7 +11434,7 @@ radial glial cells acting as neural progenitors throughout life. A fully differentiated plasma cell that lives for months. GOC:msz GO_REF:0000031 - PMID:16014527 + PMID:16014527 @@ -11761,7 +11454,6 @@ radial glial cells acting as neural progenitors throughout life. CD20-negative B cell FMA:84371 CD27-positive, CD38-positive, CD20-negative B cell - cell This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. plasmablast @@ -11797,7 +11489,6 @@ radial glial cells acting as neural progenitors throughout life. haematopoietic cell haemopoietic cell hemopoietic cell - cell hematopoietic cell @@ -11822,7 +11513,6 @@ radial glial cells acting as neural progenitors throughout life. cDC dendritic reticular cell type 1 DC - cell Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. conventional dendritic cell @@ -11847,7 +11537,6 @@ radial glial cells acting as neural progenitors throughout life. - cell Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor @@ -11858,9 +11547,9 @@ radial glial cells acting as neural progenitors throughout life. + Granule cell that is part of the cerebellum. BTO:0004278 - cell cerebellar granule cell @@ -11885,7 +11574,6 @@ radial glial cells acting as neural progenitors throughout life. Granule cell that is part of the cerebral cortex. - cell cortical granule cell @@ -11901,8 +11589,8 @@ radial glial cells acting as neural progenitors throughout life. + Granule cell that is part of the hippocampus. - cell hippocampal granule cell @@ -11921,7 +11609,6 @@ radial glial cells acting as neural progenitors throughout life. A connective tissue cell found in bone. adiehl 2011-11-16T04:28:16Z - cell bone cell @@ -11947,7 +11634,6 @@ radial glial cells acting as neural progenitors throughout life. Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone. VSAO:0000117 - cl VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 non-terminally differentiated osteoblast @@ -11969,7 +11655,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte - cell This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'. Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells. CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell @@ -11996,7 +11681,6 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. tmeehan 2010-01-06T03:43:27Z - cell hematopoietic oligopotent progenitor cell, lineage-negative @@ -12016,7 +11700,6 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. 2017-01-30T20:20:48Z - cell innate lymphoid cell @@ -12025,8 +11708,8 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. GOC:add GOC:dsd - PMID:23292121 - PMID:23348417 + PMID:23292121 + PMID:23348417 @@ -12038,7 +11721,6 @@ radial glial cells acting as neural progenitors throughout life. An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. 2017-01-30T20:42:44Z - cell group 1 innate lymphoid cell @@ -12047,7 +11729,7 @@ radial glial cells acting as neural progenitors throughout life. An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. GOC:add GOC:dsd - PMID:23348417 + PMID:23348417 @@ -12057,13 +11739,13 @@ radial glial cells acting as neural progenitors throughout life. A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor. + MESH:D000069797 beige brown adipocyte beige fat cell beige/brite adipocyte brite adipocyte brite cell brite fat cell - cell beige adipocyte @@ -12102,7 +11784,6 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte of B lineage that is CD19-positive. https://orcid.org/0000-0001-9990-8331 - cell Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex). lymphocyte of B lineage, CD19-positive @@ -12127,7 +11808,6 @@ radial glial cells acting as neural progenitors throughout life. B-lymphocyte, CD19-positive CD19+ B cell CD19-positive B cell - cell B cell, CD19-positive @@ -12153,7 +11833,6 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive CD8-positive, alpha-beta memory T-cell, CD45RO-positive CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive - cell CD8-positive, alpha-beta memory T cell, CD45RO-positive @@ -12168,7 +11847,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. GOC:tfm GO_REF:0000031 - PMID:20146720 + PMID:20146720 @@ -12187,7 +11866,6 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive CD4-positive, alpha-beta memory T-cell, CD45RO-positive CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive - cell CD4-positive, alpha-beta memory T cell, CD45RO-positive @@ -12225,7 +11903,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-01-19T02:51:58Z MDP - cell macrophage dendritic cell progenitor @@ -12239,7 +11916,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. GOC:tfm - PMID:19273628 + PMID:19273628 @@ -12259,7 +11936,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-04-27T12:46:33Z BMCP - cell There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. basophil mast progenitor cell @@ -12267,7 +11943,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa - GOC:ak + GOC:ak GOC:dsd GOC:tfm PMCID:PMC1312421 @@ -12288,7 +11964,6 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. tmeehan 2010-01-06T03:43:20Z - cell hematopoietic lineage restricted progenitor cell @@ -12314,7 +11989,6 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. tmeehan 2010-01-06T03:43:27Z - cell This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). hematopoietic oligopotent progenitor cell @@ -12338,7 +12012,6 @@ radial glial cells acting as neural progenitors throughout life. 2009-10-29T04:01:27Z T(FH) Tfh - cell follicular B helper T cell follicular T cell follicular T-cell @@ -12358,47 +12031,47 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. GOC:tfm - PMID:19855402 - PMID:20107805 - PMID:22043829 + PMID:19855402 + PMID:20107805 + PMID:22043829 T(FH) - PMID:20207847 + PMID:20207847 Tfh - PMID:20107805 + PMID:20107805 PMID:20383172 follicular B helper T cell - PMID:22043829 + PMID:22043829 follicular T cell - PMID:20107805 - PMID:21914188 + PMID:20107805 + PMID:21914188 follicular T-helper cell - PMID:22552227 + PMID:22552227 follicular helper T cell - PMID:22649468 + PMID:22649468 @@ -12416,7 +12089,6 @@ radial glial cells acting as neural progenitors throughout life. A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. tmeehan 2009-10-29T04:09:16Z - cell immature NK T cell stage I @@ -12430,7 +12102,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. GOC:tfm - PMID:17589542 + PMID:17589542 @@ -12449,7 +12121,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2009-10-29T04:13:43Z NKT.44-NK1.1-.Th - cell NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. immature NK T cell stage II @@ -12464,7 +12135,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-low, CD44-negative, NK1.1-negative NK T cell. GOC:tfm - PMID:17589542 + PMID:17589542 http://www.immgen.org/index_content.html @@ -12484,7 +12155,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2009-10-29T04:14:48Z NKT.44+.NK1.1-.Th - cell immature NK T cell stage III @@ -12497,7 +12167,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell. - PMID:17589542 + PMID:17589542 @@ -12516,7 +12186,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2009-10-29T04:17:38Z NKT.44+.NK1.1-.Th - cell immature NK T cell stage IV @@ -12530,7 +12199,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. GOC:tfm - PMID:17589542 + PMID:17589542 http://www.immgen.org/index_content.html @@ -12540,14 +12209,13 @@ radial glial cells acting as neural progenitors throughout life. - A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. + A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. tmeehan 2010-04-28T10:50:07Z - fraction A - cell + fraction A pre pro B cell Markers associated with mouse cells. - Fraction A pre-pro B cell + fraction A pre-pro B cell @@ -12558,11 +12226,11 @@ radial glial cells acting as neural progenitors throughout life. - A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. - GOC:ak + A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. + GOC:ak GOC:tfm - PMID:12633665 - PMID:17582343 + PMID:12633665 + PMID:17582343 http://www.immgen.org/index_content.html @@ -12575,7 +12243,6 @@ radial glial cells acting as neural progenitors throughout life. A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. tmeehan 2010-04-28T11:19:11Z - cell Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. early pro-B cell @@ -12609,7 +12276,6 @@ radial glial cells acting as neural progenitors throughout life. A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive. tmeehan 2010-04-28T12:06:06Z - cell Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. late pro-B cell @@ -12637,7 +12303,6 @@ radial glial cells acting as neural progenitors throughout life. A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes. tmeehan 2010-06-22T10:46:12Z - cell melanophage @@ -12678,7 +12343,6 @@ radial glial cells acting as neural progenitors throughout life. type 1 pneumocyte type I alveolar cells type I alveolar epithelial cells - cell type I pneumocyte @@ -12686,7 +12350,7 @@ radial glial cells acting as neural progenitors throughout life. A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. GOC:tfm - PMID:20054144 + PMID:20054144 http://www.copewithcytokines.de @@ -12716,7 +12380,6 @@ radial glial cells acting as neural progenitors throughout life. type II alveolar cell type II alveolar epithelial cell type II alveolocyte - cell lung type II cell type II pneumocyte @@ -12744,7 +12407,6 @@ radial glial cells acting as neural progenitors throughout life. CALOHA:TS-0737 FMA:63032 acinar cell of pancreas - cell pancreatic acinar cell @@ -12777,7 +12439,6 @@ radial glial cells acting as neural progenitors throughout life. Kultschitzky cell of bronchiole bronchiolar Kulchitsky cell respiratory enterochromaffin cell - cell Feyrter cell @@ -12800,7 +12461,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-10T10:48:54Z FMA:62939 - cell type A enteroendocrine cell @@ -12828,7 +12488,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-06-29T03:38:14Z FMA:69075 - cell endo-epithelial cell @@ -12856,7 +12515,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-06-29T03:38:22Z FMA:69074 - cell ecto-epithelial cell @@ -12885,7 +12543,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-06-29T03:49:14Z FMA:69076 epithelial mesenchymal cell - cell meso-epithelial cell @@ -12908,7 +12565,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:62455 centroacinar cell of Langerhans pancreatic centroacinar cell - cell pancreatic centro-acinar cell @@ -12935,7 +12591,6 @@ radial glial cells acting as neural progenitors throughout life. adremergic chromaffin cell adrenal secreting cell of the adrenal medulla epiniphrine secreting cell of the adrenal medulla - cell type II cell of adrenal medulla @@ -12963,7 +12618,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-07-14T10:12:24Z FMA:69321 noradrenergic chromaffin cell - cell type I cell of adrenal medulla @@ -12977,7 +12631,7 @@ radial glial cells acting as neural progenitors throughout life. A chromaffin cell of the adrenal medulla that produces norepinephrine. GOC:tfm - ISBN:068340007X + ISBN:068340007X @@ -12992,7 +12646,6 @@ radial glial cells acting as neural progenitors throughout life. Boettcher's cell Bottcher cell Bottcher's cell - cell Boettcher cell @@ -13000,7 +12653,7 @@ radial glial cells acting as neural progenitors throughout life. A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport. GOC:tfm - http://en.wikipedia.org/wiki/Boettcher_cell + http://en.wikipedia.org/wiki/Boettcher_cell @@ -13016,7 +12669,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:86573 ICC intestinal pacemaker cell - cell Some argue this cell type is of mesenchymal origin. interstitial cell of Cajal @@ -13052,9 +12704,9 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-23T09:49:53Z EHDAA2:0004716 FMA:85543 + MESH:D059705 WBbt:0008429 XAO:0000262 - cell polar body @@ -13062,7 +12714,7 @@ radial glial cells acting as neural progenitors throughout life. One of two small cells formed by the first and second meiotic division of oocytes. GOC:tfm - ISBN:068340007X + ISBN:068340007X http://en.wikipedia.org/wiki/Polar_body @@ -13077,7 +12729,7 @@ radial glial cells acting as neural progenitors throughout life. 2010-07-22T04:48:15Z BTO:0004850 FMA:83621 - cell + MESH:D001854 MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. bone marrow cell @@ -13109,7 +12761,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:69545 adrenal cortex cell adrenocortical cell - cell cortical cell of adrenal gland @@ -13140,7 +12791,6 @@ radial glial cells acting as neural progenitors throughout life. Tc17 T-lymphocyte Th17 CD8-positive T cell Th17 non-TFH CD8-positive T cell - cell This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells. Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition). Tc17 cell @@ -13178,7 +12828,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-23T12:10:31Z FMA:72299 ovarian stromal cell - cell stromal cell of ovary @@ -13208,7 +12857,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:67755 vascular endothelial cell cubodial endothelial cell of vascular tree - cell These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. endothelial cell of vascular tree @@ -13236,7 +12884,6 @@ radial glial cells acting as neural progenitors throughout life. sebocyte BTO:0004613 FMA:70953 - cell acinar cell of sebaceous gland @@ -13262,7 +12909,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-26T08:31:08Z FMA:70556 - cell general ecto-epithelial cell @@ -13282,7 +12928,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-25T01:29:07Z FMA:79800 - cell phalangeal cell @@ -13304,7 +12949,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-26T01:47:13Z FMA:67870 - cell olfactory epithelial cell @@ -13326,9 +12970,8 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-26T01:58:54Z CL:1000395 - horizontal basal call + horizontal basal cell FMA:62303 - cell basal cell of olfactory epithelium @@ -13356,7 +12999,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-26T01:59:18Z FMA:67874 blastema cell of olfactory epithelium - cell globose cell of olfactory epithelium @@ -13378,7 +13020,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-25T02:02:48Z FMA:79797 interdental cell - cell interdental cell of cochlea @@ -13396,7 +13037,6 @@ radial glial cells acting as neural progenitors throughout life. - A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells. @@ -13406,7 +13046,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001033 Goormaghtigh cell polar cushion cells - cell lacis cell extraglomerular mesangial cell @@ -13430,13 +13069,14 @@ radial glial cells acting as neural progenitors throughout life. + A cell within the follicle of an ovary. + tmeehan 2010-08-25T03:01:27Z EMAPA:31247 FMA:70589 - cell follicular cell of ovary @@ -13445,6 +13085,12 @@ radial glial cells acting as neural progenitors throughout life. A cell within the follicle of an ovary. GOC:tfm + + + + + + @@ -13457,7 +13103,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-25T03:22:08Z CL:1000399 FMA:62948 - cell epithelial cell of stomach @@ -13484,7 +13129,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-25T03:38:51Z CL:1000404 FMA:63464 - cell mucous cell of stomach @@ -13505,7 +13149,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-25T03:45:10Z FMA:62949 - cell surface mucosal cell of stomach @@ -13527,7 +13170,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-26T01:59:22Z FMA:62304 horizontal basal cells - cell basal proper cell of olfactory epithelium @@ -13549,7 +13191,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-30T12:54:27Z FMA:83519 - cell granulocytopoietic cell @@ -13575,7 +13216,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-08-30T01:27:48Z FMA:83552 - cell monopoietic cell @@ -13593,44 +13233,20 @@ radial glial cells acting as neural progenitors throughout life. - - - - - A stem cell that can give rise to the cells of the liver. - tmeehan - 2010-08-30T02:00:42Z - FMA:86577 - cell - hepatic stem cell - - - - - - true - - - - - A stem cell that can give rise to the cells of the liver. - GOC:tfm - - - - - + A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue. + Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': "... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)". tmeehan 2010-08-30T02:01:49Z CL:1000036 BTO:0004270 FMA:86576 hepatic oval cell - cell + hepatic progenitor cell + liver progenitor cell hepatic oval stem cell @@ -13639,6 +13255,26 @@ radial glial cells acting as neural progenitors throughout life. A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue. PMID:17901986 + + + + Liver progenitor cells have been variously named in rodent and human studies as oval cells, hepatic progenitor cells, liver stem cells, ductular reactions, or atypical ductular cells. They were first described as oval cells in rats due to their large nuclear-to-cytoplasm ratio and oval-shaped nuclei. On the difference between 'hepatic liver stem cells' (HLSC) and 'oval cells': "... unlike a well-known hepatic progenitor cell population, known as oval cells in rodents, HLSCs do not express CK-7, CK-19, c-kit, CD133 and alpha-smooth muscle actin (α-SMA) (Gaudio et al., 2009)". + + + + + + + hepatic progenitor cell + + + + + + + liver progenitor cell + + @@ -13651,7 +13287,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-02T02:09:14Z CL:1000407 FMA:66816 - cell epithelial cell of tracheobronchial tree @@ -13673,7 +13308,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:84448 oxidative muscle fiber red muscle fiber - cell red muscle cell @@ -13697,16 +13331,14 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001812 CALOHA:TS-0940 FMA:84413 - MESH:A02.633.565.700 slow twitch fiber slow twitch muscle cell + slow twitch muscle fiber + slow-twitch muscle fiber type 1 muscle cell type 1 muscle fiber type I muscle fiber - cell intermediate muscle fiber - slow twitch muscle fiber - slow-twitch muscle fiber type I muscle cell @@ -13718,21 +13350,21 @@ radial glial cells acting as neural progenitors throughout life. - - intermediate muscle fiber - MESH:A02.633.565.700 + + slow twitch muscle fiber + MESH:D018657 - - slow twitch muscle fiber - MESH:A02.633.565.700 + + slow-twitch muscle fiber + MESH:D018657 - slow-twitch muscle fiber - MESH:A02.633.565.700 + intermediate muscle fiber + MESH:D018657 @@ -13749,7 +13381,6 @@ radial glial cells acting as neural progenitors throughout life. type 2 muscle cell type 2 muscle fiber type II muscle fiber - cell type II muscle cell @@ -13769,7 +13400,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-02T03:28:48Z FMA:84449 - cell white muscle cell @@ -13797,7 +13427,6 @@ radial glial cells acting as neural progenitors throughout life. type 2a muscle cell type 2a muscle fiber type IIa muscle fiber - cell type IIa muscle cell @@ -13821,7 +13450,6 @@ radial glial cells acting as neural progenitors throughout life. type 2b muscle cell type 2b muscle fiber type IIb muscle fiber - cell type IIb muscle cell @@ -13844,7 +13472,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-07T01:58:00Z immature DEC precursor immature DETC precursor - cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. immature dendritic epithelial T cell precursor @@ -13868,7 +13495,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-07T10:38:03Z FMA:70950 - cell vertebrate lens cell @@ -13889,7 +13515,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-07T10:45:45Z FMA:63181 - cell anterior lens cell @@ -13911,7 +13536,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-07T10:45:47Z FMA:67559 - cell lens epithelial cell @@ -13945,7 +13569,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-07T10:53:39Z secondary lens fibre - cell secondary lens fiber @@ -13973,7 +13596,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-07T11:19:01Z FMA:70613 primary lens fibre - cell primary lens fiber @@ -13994,7 +13616,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-07T03:32:33Z FMA:67513 - cell nucleate cell @@ -14013,7 +13634,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. tmeehan 2010-09-08T09:26:53Z - cell epithelial cell of alimentary canal @@ -14036,7 +13656,6 @@ radial glial cells acting as neural progenitors throughout life. CL:1000292 BTO:0004297 FMA:256157 - cell epithelial cell of colon epithelial cell of large intestine @@ -14064,7 +13683,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-08T09:41:46Z CL:1000293 FMA:256159 - cell epithelial cell of small intestine @@ -14092,7 +13710,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-08T02:29:38Z CL:1000429 FMA:70547 - cell epithelial cell of parathyroid gland @@ -14117,7 +13734,6 @@ radial glial cells acting as neural progenitors throughout life. A cell type that secretes histamine. tmeehan 2010-09-10T03:04:42Z - cell histamine secreting cell @@ -14139,7 +13755,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-13T04:09:27Z FMA:70606 PE - cell pigmented ciliary epithelial cell @@ -14160,7 +13775,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-14T12:00:07Z FMA:70657 epithelial cell of gland of skin - cell epithelial cell of skin gland @@ -14181,7 +13795,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-14T03:31:38Z FMA:79796 - cell supporting cell of cochlea @@ -14203,7 +13816,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-15T01:34:57Z CALOHA:TS-2040 FMA:70333 - cell neural cell @@ -14227,7 +13839,7 @@ radial glial cells acting as neural progenitors throughout life. CL:1000406 CALOHA:TS-2096 FMA:63875 - cell + MESH:D003239 connective tissue cell @@ -14257,7 +13869,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:82840 FMA:82841 WBbt:0007028 - cell embryonic cell (metazoa) @@ -14277,7 +13888,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-20T02:00:00Z BTO:0002922 - cell bronchial epithelial cell @@ -14296,7 +13906,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury. tmeehan 2010-09-20T02:10:36Z - cell basal epithelial cell of tracheobronchial tree @@ -14316,7 +13925,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-20T02:31:53Z BTO:0001107 - cell preadipocyte @@ -14336,7 +13944,6 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha). tmeehan 2010-09-20T02:38:38Z - cell brown preadipocyte @@ -14358,7 +13965,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-20T04:00:02Z dNK cell decidual NK cell - cell decidual natural killer cell, human @@ -14380,7 +13986,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-21T04:41:06Z pancreatic endocrine progenitor pancreatic islet progenitor cell - cell progenitor cell of endocrine pancreas @@ -14402,7 +14007,6 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell that exists during embryogenesis. tmeehan 2010-09-22T09:05:13Z - cell gestational hematopoietic stem cell @@ -14422,7 +14026,6 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative. tmeehan 2010-09-22T09:08:32Z - cell fetal liver hematopoietic progenitor cell @@ -14450,7 +14053,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-22T09:08:34Z hemangioblast precursor - cell yolk sac hematopoietic stem cell @@ -14485,7 +14087,6 @@ radial glial cells acting as neural progenitors throughout life. primitive erythroblast primitive erythrocyte primitive erythroid cell - cell primitive red blood cell @@ -14519,7 +14120,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-22T09:38:32Z macrocyte - cell fetal derived definitive erythrocyte @@ -14553,7 +14153,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-22T10:47:28Z EryP-CFC inner blood island hemangioblast - cell primitive erythroid progenitor @@ -14567,7 +14166,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41. GOC:tfm - ISBN:0813817986 + ISBN:0813817986 PMID:20711979 @@ -14582,7 +14181,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-23T04:38:49Z BTO:0004533 airway epithelial cell - cell respiratory epithelial cell @@ -14608,7 +14206,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-23T04:42:27Z respiratory mucosa goblet cells - cell respiratory goblet cell @@ -14637,7 +14234,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001268 FMA:72300 WBbt:0008378 - cell somatic cell @@ -14660,9 +14256,9 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-24T01:13:01Z CL:0000369 + FBbt:00005812 myotubule single cell sarcomere - cell myotube @@ -14686,7 +14282,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-24T01:49:31Z ear receptor cell - cell ear hair cell @@ -14715,7 +14310,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-09-24T02:06:10Z Schwann cell precursor cell - cell Schwann cell precursor @@ -14742,7 +14336,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-09-24T02:10:31Z Schwann cell ZFA:0001725 - cell immature Schwann cell @@ -14771,7 +14364,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-07T02:05:46Z mature DEC precursor mature DETC precursor - cell NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. mature dendritic epithelial T cell precursor @@ -14792,7 +14384,6 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte found in the fetal thymus. tmeehan 2010-10-07T02:28:25Z - cell fetal thymocyte @@ -14811,7 +14402,6 @@ radial glial cells acting as neural progenitors throughout life. An immature or mature cell of the first erythroid lineage to arise during embryonic development. tmeehan 2010-10-12T11:22:41Z - cell primitive erythroid lineage cell @@ -14836,7 +14426,7 @@ radial glial cells acting as neural progenitors throughout life. A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells. tmeehan 2010-10-12T12:21:16Z - cell + MESH:D055018 hemangioblast @@ -14844,7 +14434,7 @@ radial glial cells acting as neural progenitors throughout life. A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells. GOC:tfm - ISBN:0813817986 + ISBN:0813817986 PMID:11495698 @@ -14859,7 +14449,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-12T01:56:15Z CD3e-positive T cell mature T-cell - cell CD3epsilon T cell mature T cell @@ -14888,7 +14477,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0001372 CALOHA:TS-1042 immature T-cell - cell immature T cell @@ -14916,7 +14504,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-15T09:24:08Z CALOHA:TS-0864 FMA:66785 - cell enucleated reticulocyte @@ -14930,7 +14517,7 @@ radial glial cells acting as neural progenitors throughout life. A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. GOC:tfm - ISBN:0-12203-052-4 + ISBN:0-12203-052-4 ISBN:0721601464 @@ -14945,7 +14532,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T01:16:24Z ETP preT.ETP.Th - cell ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. early T lineage precursor @@ -14975,7 +14561,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-10-21T01:59:06Z T.DP.sm.Th - cell resting double-positive thymocyte @@ -15009,7 +14594,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T01:59:11Z T.DPb.Th activated double-positive thymocyte - cell double-positive blast @@ -15042,7 +14626,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-10-21T02:11:52Z T.DP69+.Th - cell CD69-positive double-positive thymocyte @@ -15075,7 +14658,7 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-10-21T02:29:19Z T.4int8+.Th - cell + T_4int8+_Th CD4-intermediate, CD8-positive double-positive thymocyte @@ -15107,8 +14690,8 @@ radial glial cells acting as neural progenitors throughout life. A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor. tmeehan 2010-10-21T02:29:23Z - T.4int8+.th - cell + T.4+8int.Th + T_4+8int_Th CD4-positive, CD8-intermediate double-positive thymocyte @@ -15142,7 +14725,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T02:43:52Z CD24-positive, CD4 single-positive semimature thymocyte T.4SP24int.Th - cell Described in the immgene database as being CD24-intermediate. CD24-positive, CD4 single-positive thymocyte @@ -15177,7 +14759,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T02:46:02Z T.4SP69+.Th intermediate CD4-single-positive - cell CD69-positive, CD4-positive single-positive thymocyte @@ -15211,7 +14792,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T02:59:10Z CD24-positive, CD8 single-positive semimature thymocyte T.8SP24int.Th - cell Described in the immgene database as being CD24-intermediate. CD24-positive, CD8 single-positive thymocyte @@ -15246,7 +14826,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-10-21T02:59:14Z T.8SP69+.Th intermediate CD8-single-positive - cell CD69-positive, CD8-positive single-positive thymocyte @@ -15279,7 +14858,6 @@ radial glial cells acting as neural progenitors throughout life. A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. tmeehan 2010-10-21T03:31:19Z - cell T.4SP24-.Th mature CD4 single-positive thymocyte @@ -15313,7 +14891,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-10-21T03:51:50Z T.8SP24-.Th - cell mature CD8 single-positive thymocyte @@ -15336,30 +14913,69 @@ radial glial cells acting as neural progenitors throughout life. + - The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. + A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. + http://orcid.org/0000-0002-1773-2692 tmeehan 2010-11-10T02:51:34Z - cell + O-2A/OPC + O2A/OPC + oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell + oligodendrocyte/type-2 astrocyte progenitor cell + MESH:D000073637 + This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). oligodendrocyte precursor cell - - - - - true - - The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. + A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. GOC:tfm + PMID:10704434 + PMID:11756508 PMID:20142420 + PMID:2182078 + PMID:24133281 + PMID:9826671 + + + + + O-2A/OPC + PMID:24133281 + + + + + O2A/OPC + PMID:11756508 + + + + + oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell + PMID:2253328 + + + + + oligodendrocyte/type-2 astrocyte progenitor cell + http://orcid.org/0000-0002-0819-0473 + PMID:24133281 + + + + + This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). + ISBN:9780702028991 + PMID:10704434 + PMID:2182078 @@ -15372,7 +14988,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-12-03T03:03:02Z MP:0002262 - cell nasal mucosa goblet cell @@ -15393,7 +15008,6 @@ radial glial cells acting as neural progenitors throughout life. The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule. tmeehan 2010-12-03T03:11:48Z - cell peritubular myoid cell @@ -15420,7 +15034,6 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that produces pigment in the dermis. tmeehan 2010-12-03T03:17:05Z - cell dermal melanocyte @@ -15441,7 +15054,6 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that produces pigment in the epithelium. tmeehan 2010-12-03T03:17:14Z - cell The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium. epithelial melanocyte @@ -15468,7 +15080,6 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium. tmeehan 2010-12-03T03:25:32Z - cell retinal melanocyte @@ -15496,7 +15107,6 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) . tmeehan 2010-12-03T03:29:15Z - cell strial intermediate cell @@ -15516,7 +15126,6 @@ radial glial cells acting as neural progenitors throughout life. A neuronal receptor that respond to mechanical pressure or distortion in the skin. tmeehan 2010-12-06T02:53:30Z - cell cutaneous/subcutaneous mechanoreceptor cell @@ -15537,22 +15146,21 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-12-06T02:55:24Z giant trophoblast cell - cell trophoblast giant cell - - - - - true - A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta. GOC:tfm MP:0001714 - MP:19876834 + MP:19876834 + + + + + + true @@ -15566,7 +15174,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-12-06T03:03:38Z CD4-CD8- T cell double negative T cell - cell These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes. double negative thymocyte @@ -15593,7 +15200,6 @@ radial glial cells acting as neural progenitors throughout life. A supporting cell of the organ of Corti. tmeehan 2010-12-06T03:09:01Z - cell organ of Corti supporting cell @@ -15613,7 +15219,6 @@ radial glial cells acting as neural progenitors throughout life. A specialized cell involved in auditory sensory perception. tmeehan 2010-12-06T03:18:43Z - cell auditory epithelial cell @@ -15632,7 +15237,6 @@ radial glial cells acting as neural progenitors throughout life. A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria. tmeehan 2010-12-06T03:20:41Z - cell strial marginal cell @@ -15652,7 +15256,6 @@ radial glial cells acting as neural progenitors throughout life. A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions. tmeehan 2010-12-06T03:26:53Z - cell Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] strial basal cell @@ -15679,22 +15282,21 @@ radial glial cells acting as neural progenitors throughout life. FMA:83808 FMA:84791 heart cell - cell From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. cardiocyte - - - - A cell located in the heart, including both muscle and non muscle cells. - GOC:tfm - true + + + + A cell located in the heart, including both muscle and non muscle cells. + GOC:tfm + @@ -15707,7 +15309,6 @@ radial glial cells acting as neural progenitors throughout life. 2010-12-07T09:50:41Z embryonic cardiomyocyte neonatal cardiomyocyte - cell fetal cardiomyocyte @@ -15727,10 +15328,10 @@ radial glial cells acting as neural progenitors throughout life. A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response. tmeehan 2010-12-07T09:54:50Z + MESH:D000075942 IEL intraepithelial T cell intraepithelial T-cell - cell intraepithelial lymphocyte @@ -15757,7 +15358,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2010-12-07T12:56:56Z spongiotrophoblast - cell spongiotrophoblast cell @@ -15779,7 +15379,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2011-02-08T10:46:34Z KUPO:0001019 - cell kidney epithelial cell @@ -15805,7 +15404,6 @@ radial glial cells acting as neural progenitors throughout life. A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both. tmeehan 2011-02-08T01:37:59Z - cell renal filtration cell @@ -15825,7 +15423,6 @@ radial glial cells acting as neural progenitors throughout life. An endothelial progenitor cell that participates in angiogenesis during development. tmeehan 2011-02-28T04:20:39Z - cell See CL:0002619. embryonic blood vessel endothelial progenitor cell @@ -15845,7 +15442,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the intestine. tmeehan 2011-03-01T05:18:31Z - cell intestinal epithelial cell @@ -15866,7 +15462,7 @@ radial glial cells acting as neural progenitors throughout life. 2011-03-02T01:19:27Z BTO:0001220 CALOHA:TS-0898 - cell + MESH:D012583 Schwann cell @@ -15885,7 +15481,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the kidney cortex. KUPO:0001016 - cell renal cortical epithelial cell @@ -15916,7 +15511,6 @@ radial glial cells acting as neural progenitors throughout life. A neural crest cell that gives rise to cells of the enteric nervous system. tmeehan 2011-03-06T07:24:35Z - cell migratory enteric neural crest cell @@ -15931,19 +15525,13 @@ radial glial cells acting as neural progenitors throughout life. - + + A neuron of the hippocampus. tmeehan 2011-03-06T07:31:49Z - cell hippocampal neuron - - - - - true - @@ -15953,29 +15541,6 @@ radial glial cells acting as neural progenitors throughout life. - - - - OBSOLETE. A CNS neuron of the cerebral cortex. - CL:0010012 - tmeehan - 2011-03-06T07:37:08Z - BTO:0004102 - FMA:84104 - cortical neuron - cell - obsolete neuron of cerebral cortex - true - - - - - OBSOLETE. A CNS neuron of the cerebral cortex. - GOC:tfm - - - - @@ -15984,7 +15549,6 @@ radial glial cells acting as neural progenitors throughout life. A cell of the seminiferous tubule epithelium. tmeehan 2011-03-15T11:59:23Z - cell seminiferous tubule epithelial cell @@ -16008,7 +15572,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2011-06-21T12:29:31Z - cell epithelial cell of lower respiratory tract @@ -16030,7 +15593,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-06-21T03:11:10Z airway basal cell airway basal stem cell - cell respiratory basal cell @@ -16053,7 +15615,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-06-21T03:26:08Z BASC basal epithelial cell of bronchioalveolar duct junction - cell bronchioalveolar stem cell @@ -16075,7 +15636,6 @@ radial glial cells acting as neural progenitors throughout life. tmeehan 2011-07-08T04:03:01Z FMA:87194 - cell glandular cell of the large intestine @@ -16103,7 +15663,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-07-11T01:20:35Z CALOHA:TS-1284 FMA:86554 - cell glandular cell of stomach @@ -16128,7 +15687,6 @@ radial glial cells acting as neural progenitors throughout life. A fibrocyte of the cochlea that has specialized structural and molecular adaptions. tmeehan 2011-07-11T03:35:01Z - cell otic fibrocyte @@ -16136,7 +15694,7 @@ radial glial cells acting as neural progenitors throughout life. A fibrocyte of the cochlea that has specialized structural and molecular adaptions. GOC:tfm - PMID:18353863 + PMID:18353863 @@ -16150,7 +15708,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-07-11T03:40:40Z type II otic fibrocyte type II spiral ligament fibrocyte - cell type 2 otic fibrocyte @@ -16158,13 +15715,13 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. GOC:tfm - PMID:18353863 + PMID:18353863 type II spiral ligament fibrocyte - MP:0004488 + MP:0004488 @@ -16178,7 +15735,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-07-11T03:40:46Z type IV otic fibrocyte type IV spiral ligament fibrocyte - cell type 4 otic fibrocyte @@ -16186,7 +15742,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall. GOC:tfm - PMID:18353863 + PMID:18353863 @@ -16206,7 +15762,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-07-11T03:40:50Z type III otic fibrocyte type III spiral ligament fibrocyte - cell type 3 otic fibrocyte @@ -16214,7 +15769,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that lines the otic capsule. GOC:tfm - PMID:18353863 + PMID:18353863 @@ -16234,7 +15789,6 @@ radial glial cells acting as neural progenitors throughout life. 2011-07-11T03:39:27Z type I otic fibrocyte type I spiral ligament fibrocyte - cell type 1 otic fibrocyte @@ -16242,7 +15796,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. GOC:tfm - PMID:18353863 + PMID:18353863 @@ -16266,7 +15820,6 @@ radial glial cells acting as neural progenitors throughout life. A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. tmeehan 2011-08-16T02:38:01Z - cell retinal progenitor cell @@ -16294,7 +15847,6 @@ radial glial cells acting as neural progenitors throughout life. A neuroblast derived from a neural crest cell. tmeehan 2011-08-22T09:24:15Z - cell neural crest derived neuroblast @@ -16313,7 +15865,6 @@ radial glial cells acting as neural progenitors throughout life. terryh 2011-10-25T03:49:41Z - cell kidney cortical cell @@ -16330,7 +15881,6 @@ radial glial cells acting as neural progenitors throughout life. A CNS interneuron located in the spinal cord. - cell Is_a interneuron, part_of UBERON:0002240. spinal cord interneuron @@ -16355,7 +15905,6 @@ radial glial cells acting as neural progenitors throughout life. A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts. - cell renal principal cell @@ -16374,9 +15923,10 @@ radial glial cells acting as neural progenitors throughout life. A cuboidal epithelial cell of the kidney that regulates acid/base balance. + http://orcid.org/0000-0002-1773-2692 FMA:86560 intercalated cell - cell + Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells. renal intercalated cell @@ -16385,6 +15935,12 @@ radial glial cells acting as neural progenitors throughout life. A cuboidal epithelial cell of the kidney that regulates acid/base balance. CL:CVS + + + + Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells. + PMID:25632105 + @@ -16397,7 +15953,6 @@ radial glial cells acting as neural progenitors throughout life. multi-ciliated cell multiciliated cell multiciliated epithelial cell - cell multi-ciliated epithelial cell @@ -16417,7 +15972,6 @@ radial glial cells acting as neural progenitors throughout life. A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells. auditory epithelial support cell - cell auditory epithelial supporting cell @@ -16435,7 +15989,6 @@ radial glial cells acting as neural progenitors throughout life. A cell that secretes ghrelin, the peptide hormone that stimulates hunger. - cell ghrelin secreting cell @@ -16454,7 +16007,6 @@ radial glial cells acting as neural progenitors throughout life. Ghrelin secreting cells found in the endocrine pancreas. pancreatic E cell - cell In mammals the endocrine pancreas is called the Islets of Langerhans. pancreatic epsilon cell @@ -16471,16 +16023,19 @@ radial glial cells acting as neural progenitors throughout life. - Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. hepatoblast + https://github.com/obophenotype/cell-ontology/issues/800 - Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. GOC:CVS PMID:18356246 PMID:20483998 + PMID:26798363 + https://orcid.org/0000-0003-1940-6740 @@ -16498,7 +16053,6 @@ radial glial cells acting as neural progenitors throughout life. Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins. haendel 2012-06-15T01:27:01Z - cell unsure of neural crest contribution. In VSAO we have develops_from CL:0000008 preameloblast @@ -16525,14 +16079,13 @@ radial glial cells acting as neural progenitors throughout life. Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. haendel 2012-06-27T08:27:35Z - cell premigratory neural crest cell Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. - UBERONREF:0000002 + UBERONREF:0000002 @@ -16544,7 +16097,6 @@ radial glial cells acting as neural progenitors throughout life. Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. haendel 2012-06-27T10:44:01Z - cell prechondroblast @@ -16577,7 +16129,6 @@ radial glial cells acting as neural progenitors throughout life. haendel 2012-06-27T10:57:21Z osteoprogenitor cell - cell preosteoblast @@ -16603,7 +16154,6 @@ radial glial cells acting as neural progenitors throughout life. Neuron that is part of the enteric nervous system. haendel 2012-06-28T08:20:31Z - cell enteric neuron @@ -16659,6 +16209,7 @@ radial glial cells acting as neural progenitors throughout life. A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + MESH:D018485 skeletal muscle fiber @@ -16676,6 +16227,7 @@ radial glial cells acting as neural progenitors throughout life. A muscle cell that is part of some visceral muscle + FBbt:00005070 visceral muscle cell @@ -16692,7 +16244,6 @@ radial glial cells acting as neural progenitors throughout life. An endocrine cell that is part of the pancreas. - cell pancreatic endocrine cell @@ -16715,18 +16266,6 @@ radial glial cells acting as neural progenitors throughout life. - - - - - - dos - 2017-07-12T11:11:06Z - excitatory neuron - - - - @@ -16741,7 +16280,7 @@ radial glial cells acting as neural progenitors throughout life. Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. - Wiki:Mural_cell&oldid=930603194 + Wiki:Mural_cell&oldid=930603194 @@ -16762,7 +16301,7 @@ radial glial cells acting as neural progenitors throughout life. A skeletal muscle fiber that is innervated by alpha motor neuron and generates tension by contracting, thereby allowing for skeletal movement. These fibers make up the large mass of skeletal muscle tissue and are attached to bones by tendons. DOI:10.1016/B978-0-443-10321-6.00004-7 - Wikipedia:Extrafusal_muscle_fiber&oldid=978415293 + Wikipedia:Extrafusal_muscle_fiber&oldid=978415293 @@ -16773,7 +16312,6 @@ radial glial cells acting as neural progenitors throughout life. Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. PMID:10702418 - cell retinal cell @@ -16785,12 +16323,33 @@ radial glial cells acting as neural progenitors throughout life. + + + + + A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells. + 2022-02-18T14:09:25Z + + stem Leydig cell + Leydig stem cell + + + + + A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells. + PMID:21181888 + http://orcid.org/0000-0002-0819-0473 + + + + An epithelial cell that is part_of a alveolus of lung. GOC:cjm + MESH:D056809 alveolus of lung epithelial cell May be merged with pneumocyte in future epithelial cell of alveolus of lung @@ -16814,11 +16373,13 @@ radial glial cells acting as neural progenitors throughout life. A CNS neuron of the cerebral cortex. + CL:0002609 BTO:0004102 FMA:84104 cortical neuron - cell + neuron of cerebral cortex cerebral cortex neuron + https://github.com/obophenotype/cell-ontology/issues/1359 @@ -16833,7 +16394,7 @@ radial glial cells acting as neural progenitors throughout life. - cell + MESH:D032386 cardiac myoblast @@ -16880,7 +16441,7 @@ radial glial cells acting as neural progenitors throughout life. A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation. GOC:nv MP:0009467 - PMID:10711808 + PMID:10711808 @@ -16930,7 +16491,6 @@ radial glial cells acting as neural progenitors throughout life. A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. - cell neural crest cell @@ -16984,6 +16544,25 @@ radial glial cells acting as neural progenitors throughout life. + + + + + + An astrocyte of the forebrain. + tberardini + forebrain astrocyte + astrocyte of the forebrain + + + + + + true + + + + @@ -16992,7 +16571,6 @@ radial glial cells acting as neural progenitors throughout life. A CNS neuron of the forebrain. tberardini forebrain neuron - cell neuron of the forebrain @@ -17019,14 +16597,14 @@ radial glial cells acting as neural progenitors throughout life. Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3. - PMID:1996606 + PMID:1996606 PMID:24942678 intestinal goblet cell - PMID:1996606 + PMID:1996606 @@ -17035,7 +16613,6 @@ radial glial cells acting as neural progenitors throughout life. - cell stretch receptor cell @@ -17050,7 +16627,6 @@ radial glial cells acting as neural progenitors throughout life. pillar cell of cochlea pillar cell of corti rod cell of Corti - cell cochlear pillar cell pillar cell @@ -17059,7 +16635,7 @@ radial glial cells acting as neural progenitors throughout life. A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti. GOC:tfm - PMID:12417662 + PMID:12417662 @@ -17080,7 +16656,6 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell that is part of the epithelium of intestinal villus. FMA:263046 goblet cell of epithelium of intestinal villus - cell intestinal villus goblet cell @@ -17100,7 +16675,6 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell that is part of the epithelium of large intestine. FMA:263054 goblet cell of epithelium of large intestine - cell large intestine goblet cell @@ -17120,7 +16694,6 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell that is part of the epithelium proper of duodenum. FMA:263063 goblet cell of epithelium proper of duodenum - cell duodenal goblet cell @@ -17139,7 +16712,6 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell that is part of the epithelium proper of jejunum. FMA:263065 goblet cell of epithelium proper of jejunum - cell jejunal goblet cell @@ -17158,7 +16730,6 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell that is part of the epithelium proper of ileum. FMA:263067 goblet cell of epithelium proper of ileum - cell ileal goblet cell @@ -17180,7 +16751,6 @@ radial glial cells acting as neural progenitors throughout life. CL:0002331 FMA:263120 basal cell of bronchus - cell basal cell of epithelium of bronchus @@ -17198,7 +16768,6 @@ radial glial cells acting as neural progenitors throughout life. A basal cell that is part of the epithelium of terminal bronchiole. FMA:263122 - cell basal cell of epithelium of terminal bronchiole @@ -17216,7 +16785,6 @@ radial glial cells acting as neural progenitors throughout life. A basal cell that is part of the epithelium of respiratory bronchiole. FMA:263124 - cell basal cell of epithelium of respiratory bronchiole @@ -17235,7 +16803,6 @@ radial glial cells acting as neural progenitors throughout life. A basal cell that is part of the epithelium of bronchiole. FMA:263126 - cell basal cell of epithelium of lobular bronchiole @@ -17255,7 +16822,6 @@ radial glial cells acting as neural progenitors throughout life. A chromaffin cell that is part of the adrenal gland. FMA:69794 adrenal chromaffin cell - cell chromaffin cell of adrenal gland @@ -17286,7 +16852,6 @@ radial glial cells acting as neural progenitors throughout life. A somatic stem cell that is part of the epidermis. FMA:70541 epidermal stem cell - cell stem cell of epidermis @@ -17317,7 +16882,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that is part of the sweat gland. FMA:70952 - cell epithelial cell of sweat gland @@ -17335,7 +16899,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that is part of the nephron. FMA:70965 - cell epithelial cell of nephron @@ -17356,7 +16919,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001034 Bowmans capsule epithelial cell epithelial cell of Bowman's capsule - cell epithelial cell of glomerular capsule @@ -17384,7 +16946,6 @@ radial glial cells acting as neural progenitors throughout life. FMA:70982 KUPO:0001059 epithelial cell of renal collecting tubule - cell kidney collecting duct epithelial cell @@ -17422,7 +16983,6 @@ radial glial cells acting as neural progenitors throughout life. CALOHA:TS-2374 FMA:72144 skin melanocyte - cell melanocyte of skin @@ -17459,7 +17019,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. FMA:86481 epithelial cell of bile duct - cell cholangiocyte @@ -17489,7 +17048,6 @@ radial glial cells acting as neural progenitors throughout life. goblet cell of epithelium of small intestine goblet cell of small intestine small intestinal goblet cell - cell small intestine goblet cell @@ -17513,7 +17071,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001010 - cell kidney cell @@ -17530,7 +17087,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001013 - cell kidney interstitial cell @@ -17547,7 +17103,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001017 - cell kidney medulla cell @@ -17564,7 +17119,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001023 - cell kidney glomerular epithelial cell @@ -17576,7 +17130,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001021 - cell kidney corpuscule cell @@ -17594,7 +17147,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001028 juxtaglomerulus cell - cell juxtaglomerular complex cell @@ -17617,7 +17169,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001036 - cell glomerular cell @@ -17635,7 +17186,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001012 Wikipedia:Kidney_collecting_duct_cell - cell kidney collecting duct cell @@ -17651,9 +17201,9 @@ radial glial cells acting as neural progenitors throughout life. - + + A pericyte cell located in the kidney interstitium. KUPO:0001104 - cell renal interstitial pericyte @@ -17671,7 +17221,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001128 - cell kidney collecting duct principal cell @@ -17690,7 +17239,6 @@ radial glial cells acting as neural progenitors throughout life. KUPO:0001129 http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells - cell kidney collecting duct intercalated cell @@ -17709,7 +17257,6 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the exocrine pancreas. FMA:70986 exocrine pancreas cell - cell epithelial cell of exocrine pancreas @@ -17728,14 +17275,13 @@ radial glial cells acting as neural progenitors throughout life. A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons - cl olfactory bulb interneuron A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons - PMID:18603310 + PMID:18603310 @@ -17746,14 +17292,13 @@ radial glial cells acting as neural progenitors throughout life. The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter. BTO:0003796 - NIFSTD:nifext_122 + NIFEXT:122 glomerular layer cell olfactory bulb (accessory) glomerular layer cell olfactory bulb glomerular layer cell olfactory bulb glomerularal cell olfactory bulb periglomerular cell periglomerular cell - cl periglomerular cell @@ -17766,19 +17311,19 @@ radial glial cells acting as neural progenitors throughout life. glomerular layer cell - NIFSTD:nifext_122 + NIFEXT:122 olfactory bulb (accessory) glomerular layer cell - NIFSTD:nifext_122 + NIFEXT:122 olfactory bulb glomerular layer cell - NIFSTD:nifext_122 + NIFEXT:122 @@ -17790,7 +17335,7 @@ radial glial cells acting as neural progenitors throughout life. periglomerular cell - NIFSTD:nifext_122 + NIFEXT:122 @@ -17800,7 +17345,6 @@ radial glial cells acting as neural progenitors throughout life. The subcutaneous mechanoreceptors that innervate tylotrich hair follicles. - cl hair-tylotrich neuron @@ -17817,7 +17361,6 @@ radial glial cells acting as neural progenitors throughout life. The subcutaneous mechanoreceptors that innervate vellus hairs. - cl hair-down neuron @@ -17835,7 +17378,6 @@ radial glial cells acting as neural progenitors throughout life. A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord. proprioceptive neuron - cl sensory neuron of dorsal root ganglion @@ -17866,7 +17408,6 @@ radial glial cells acting as neural progenitors throughout life. The inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus. BTO:0004778 striatal medium spiny neuron - cl medium-sized densely spiny neuron medium spiny neuron @@ -17896,7 +17437,6 @@ radial glial cells acting as neural progenitors throughout life. The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex. - cl mitral cell @@ -17913,7 +17453,6 @@ radial glial cells acting as neural progenitors throughout life. The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala. - cl olfactory bulb tufted cell @@ -17934,7 +17473,6 @@ radial glial cells acting as neural progenitors throughout life. The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system. parvocellular neuron parvocellular neurosecretory neuron - cl parvocellular neurosecretory cell @@ -17952,7 +17490,6 @@ radial glial cells acting as neural progenitors throughout life. The neurons that utilize glycine as a neurotransmitter. - cl glycinergic neuron @@ -17970,7 +17507,6 @@ radial glial cells acting as neural progenitors throughout life. The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. - cl intestinal enteroendocrine cell @@ -17988,14 +17524,13 @@ radial glial cells acting as neural progenitors throughout life. The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach. - cl stomach enteroendocrine cell The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach. - MP:0010803 + MP:0010803 @@ -18003,9 +17538,8 @@ radial glial cells acting as neural progenitors throughout life. - + Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals. - cl vomeronasal sensory neuron @@ -18022,14 +17556,13 @@ radial glial cells acting as neural progenitors throughout life. A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury. - cl bronchioalveolar stem cells A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury. - MP:0011691 + MP:0011691 @@ -18039,7 +17572,6 @@ radial glial cells acting as neural progenitors throughout life. - cl endothelial cell of lung pulmonary vessel endothelial cell lung endothelial cell @@ -18050,13 +17582,12 @@ radial glial cells acting as neural progenitors throughout life. - + A pyramidal neuron of the hippocampus. NIFSTD:sao131261273 SAO:sao131261273 hippocampus (CA) pyramidal cell hippocampus (CA) pyramidal neuron - cl hippocampal pyramidal neuron @@ -18340,7 +17871,6 @@ radial glial cells acting as neural progenitors throughout life. Any cell that is part of a pituitary gland. TermGenie 2014-03-26T22:14:56Z - cell CL:2000004 pituitary gland cell @@ -18353,6 +17883,25 @@ radial glial cells acting as neural progenitors throughout life. + + + + + Any macroglial cell that is part of a brain. + TermGenie + 2014-03-28T21:35:27Z + CL:2000005 + brain macroglial cell + + + + + Any macroglial cell that is part of a brain. + GOC:TermGenie + + + + @@ -18360,7 +17909,6 @@ radial glial cells acting as neural progenitors throughout life. Any native cell that is part of a sebaceous gland. TermGenie 2014-06-24T23:17:00Z - cell CL:2000021 sebaceous gland cell @@ -18380,7 +17928,6 @@ radial glial cells acting as neural progenitors throughout life. Any neuron that is part of a central nervous system. TermGenie 2014-06-25T01:17:43Z - cell CL:2000029 central nervous system neuron @@ -18400,7 +17947,6 @@ radial glial cells acting as neural progenitors throughout life. Any native cell that is part of a hypothalamus. TermGenie 2014-06-25T01:17:50Z - cell CL:2000030 hypothalamus cell @@ -18417,18 +17963,22 @@ radial glial cells acting as neural progenitors throughout life. - Any neuron that is part of a peripheral nervous system. + A neuron that is part of a peripheral nervous system. TermGenie 2014-06-25T02:28:17Z - cell + CL:0000111 + FMA:84664 + PNS neuron + peripheral neuron CL:2000032 peripheral nervous system neuron - Any neuron that is part of a peripheral nervous system. + A neuron that is part of a peripheral nervous system. GOC:TermGenie + ISBN:0721662544 @@ -18444,7 +17994,6 @@ radial glial cells acting as neural progenitors throughout life. BTO:0006208 vCTB villous cytotrophoblast - cell CL:2000060 Same as synctial trophoblast? placental villous trophoblast @@ -18472,7 +18021,6 @@ radial glial cells acting as neural progenitors throughout life. Any epithelial cell that is part of a female gonad. TermGenie 2014-10-07T17:59:13Z - cell CL:2000064 http://www.sciencellonline.com/site/productInformation.php?keyword=7310 ovarian surface epithelial cell @@ -18493,7 +18041,6 @@ radial glial cells acting as neural progenitors throughout life. Any leukocyte that is part of a spleen. TermGenie 2014-11-05T01:26:50Z - cell CL:2000074 Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. splenocyte @@ -18507,6 +18054,24 @@ radial glial cells acting as neural progenitors throughout life. + + + + + + A pyramidal neuron with soma located in the cerebral cortex. + + cerebral cortex pyramidal neuron + + + + + A pyramidal neuron with soma located in the cerebral cortex. + PMID:30715238 + + + + @@ -18524,6 +18089,24 @@ radial glial cells acting as neural progenitors throughout life. An auditory hair cell found in the cochlea. Wikipedia:Hair_cell + + + + + + + + A glial cell that myelinates axonal processes. + + CL:0000328 + myelinating glial cell + + + + + A glial cell that myelinates axonal processes. + DOI:10.1007/3-540-29623-9_3240 + diff --git a/src/ontology/imports/go_import.owl b/src/ontology/imports/go_import.owl index 58131d41..88fa2898 100644 --- a/src/ontology/imports/go_import.owl +++ b/src/ontology/imports/go_import.owl @@ -6077,7 +6077,7 @@ The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. GOC:add ISBN:0781735149 - PMID:15771591 + PMID:15771591 PMID:15928678 @@ -6098,7 +6098,7 @@ The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules. GOC:add ISBN:0781735149 - PMID:15771591 + PMID:15771591 @@ -6395,7 +6395,7 @@ GOC:add ISBN:0781735149 PMID:15224092 - PMID:15771591 + PMID:15771591 @@ -18460,7 +18460,7 @@ Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. - ISBN:0879693568 + ISBN:0879693568 @@ -19016,8 +19016,8 @@ A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. GOC:krc GOC:mah - PMID:16009555 - PMID:16151244 + PMID:16009555 + PMID:16151244 @@ -25520,7 +25520,7 @@ The multiplication or reproduction of cells, resulting in the expansion of a cell population. GOC:mah - GOC:mb + GOC:mb @@ -28967,7 +28967,7 @@ The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. - GOC:txnOH-2018 + GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -29010,7 +29010,7 @@ Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 + GOC:txnOH-2018 @@ -29863,7 +29863,7 @@ Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 + GOC:txnOH-2018 @@ -29902,7 +29902,7 @@ Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). - GOC:txnOH-2018 + GOC:txnOH-2018 @@ -32858,7 +32858,7 @@ The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. - GOC:dh + GOC:dh GOC:ef @@ -32878,7 +32878,7 @@ The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. - GOC:dh + GOC:dh GOC:ef @@ -38155,7 +38155,7 @@ GOC:add GO_REF:0000022 ISBN:0781735149 - PMID:15771591 + PMID:15771591 PMID:15928678 @@ -38291,7 +38291,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38415,7 +38415,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38445,7 +38445,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38474,7 +38474,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38509,7 +38509,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38544,7 +38544,7 @@ GOC:dph GOC:jid GO_REF:0000021 - ISBN:0838580343 + ISBN:0838580343 @@ -38870,7 +38870,7 @@ GOC:dph GOC:jid GO_REF:0000021 - PMID:11262869 + PMID:11262869 @@ -41068,7 +41068,7 @@ RBC differentiation - CL:0000232 + CL:0000232 @@ -41081,7 +41081,7 @@ red blood cell differentiation - CL:0000232 + CL:0000232 @@ -43010,7 +43010,7 @@ The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. - GOC:cvs + GOC:cvs @@ -46734,7 +46734,7 @@ A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins. GOC:krc - PMID:16151244 + PMID:16151244 @@ -46771,7 +46771,7 @@ A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip. GOC:krc GOC:mah - PMID:16151244 + PMID:16151244 @@ -55952,13 +55952,13 @@ RBC homeostasis - CL:0000232 + CL:0000232 red blood cell homeostasis - CL:0000232 + CL:0000232 @@ -65083,7 +65083,7 @@ Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl + GO:jl @@ -65120,7 +65120,7 @@ Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl + GO:jl @@ -66846,7 +66846,7 @@ A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation. GOC:mtg_sensu - GOC:pj + GOC:pj ISBN:0716743663 @@ -68600,13 +68600,13 @@ regulation of RBC differentiation - CL:0000232 + CL:0000232 regulation of red blood cell differentiation - CL:0000232 + CL:0000232 @@ -68654,13 +68654,13 @@ negative regulation of RBC differentiation - CL:0000232 + CL:0000232 negative regulation of red blood cell differentiation - CL:0000232 + CL:0000232 @@ -68709,13 +68709,13 @@ positive regulation of RBC differentiation - CL:0000232 + CL:0000232 positive regulation of red blood cell differentiation - CL:0000232 + CL:0000232 @@ -74998,7 +74998,7 @@ The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. GOC:add ISBN:0781735149 - PMID:15771591 + PMID:15771591 @@ -78604,7 +78604,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation. - GOC:devbiol + GOC:devbiol @@ -78645,7 +78645,7 @@ Any process that activates or increases the frequency, rate or extent of hair follicle maturation. - GOC:devbiol + GOC:devbiol @@ -78681,7 +78681,7 @@ Any process that modulates the frequency, rate or extent of hair follicle maturation. - GOC:devbiol + GOC:devbiol @@ -78706,7 +78706,7 @@ A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. - GOC:devbiol + GOC:devbiol @@ -78765,7 +78765,7 @@ Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. - GOC:devbiol + GOC:devbiol @@ -78807,7 +78807,7 @@ Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. - GOC:devbiol + GOC:devbiol @@ -78848,7 +78848,7 @@ Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. - GOC:devbiol + GOC:devbiol @@ -104939,7 +104939,7 @@ The movement of a myeloid leukocyte within or between different tissues and organs of the body. - GOC:cvs + GOC:cvs PMID:22342843 PMID:24157461 @@ -104961,7 +104961,7 @@ The movement of a granulocyte within or between different tissues and organs of the body. - GOC:cvs + GOC:cvs PMID:24163421 PMID:24193336 @@ -125836,7 +125836,7 @@ The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. CL:0000842 GOC:TermGenie - GO_REF:0000086 + GO_REF:0000086 PMID:24759906 diff --git a/src/ontology/imports/hp_import.owl b/src/ontology/imports/hp_import.owl index 63ec2a46..dd4ec7af 100644 --- a/src/ontology/imports/hp_import.owl +++ b/src/ontology/imports/hp_import.owl @@ -7,8 +7,8 @@ xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"> - - 2022-05-11 + + 2022-08-03 diff --git a/src/ontology/imports/mondo_import.owl b/src/ontology/imports/mondo_import.owl index a319fa77..6a9da47e 100644 --- a/src/ontology/imports/mondo_import.owl +++ b/src/ontology/imports/mondo_import.owl @@ -127617,19 +127617,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of respiratory system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of respiratory system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant respiratory system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -127704,13 +127704,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of paranasal sinus - MONDO:patterns/cancer + MONDO:patterns/cancer malignant paranasal sinus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -127755,7 +127755,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of paranasal sinus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -128674,19 +128674,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of anal canal - MONDO:patterns/cancer + MONDO:patterns/cancer malignant anal canal neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of anal canal - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -132548,7 +132548,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lymphatic part of lymphoid system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -132560,13 +132560,13 @@ b) intends the object or event that the mental process is about, should such exi malignant lymphatic part of lymphoid system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of lymphatic part of lymphoid system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -132756,7 +132756,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of immune system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -132768,13 +132768,13 @@ b) intends the object or event that the mental process is about, should such exi malignant immune system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of immune system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -134015,19 +134015,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of musculoskeletal system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant musculoskeletal system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of musculoskeletal system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -134128,7 +134128,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a cartilage tissue. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -134146,7 +134146,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cartilage tissue - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -134164,13 +134164,13 @@ b) intends the object or event that the mental process is about, should such exi malignant cartilage tissue neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of cartilage tissue - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -135248,19 +135248,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of sensory system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sensory system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant sensory system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -135476,7 +135476,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of integumental system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -135488,13 +135488,13 @@ b) intends the object or event that the mental process is about, should such exi malignant integumental system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of integumental system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -137238,7 +137238,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of hepatopancreatic ampulla - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -137262,7 +137262,7 @@ b) intends the object or event that the mental process is about, should such exi malignant hepatopancreatic ampulla neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -137274,7 +137274,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of hepatopancreatic ampulla - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -137404,7 +137404,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of duodenum DOID:10021 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4803 @@ -137435,13 +137435,13 @@ b) intends the object or event that the mental process is about, should such exi malignant duodenum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of duodenum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9328 @@ -138367,7 +138367,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of hindlimb long bone - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138379,13 +138379,13 @@ b) intends the object or event that the mental process is about, should such exi malignant hindlimb long bone neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of hindlimb long bone - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138562,7 +138562,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ileum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138574,7 +138574,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ileum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138582,7 +138582,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ileum DOID:10153 ICD9CM:152.2 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138693,7 +138693,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of small intestine - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -138705,7 +138705,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of small intestine - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7523 @@ -138742,7 +138742,7 @@ b) intends the object or event that the mental process is about, should such exi malignant small intestine neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7523 @@ -139790,7 +139790,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of epididymis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -139815,7 +139815,7 @@ b) intends the object or event that the mental process is about, should such exi malignant epididymis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -139823,7 +139823,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of epididymis DOID:10366 ICD9CM:187.5 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3558 @@ -140604,7 +140604,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of stomach - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -140648,7 +140648,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of stomach - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9331 @@ -140661,7 +140661,7 @@ b) intends the object or event that the mental process is about, should such exi malignant stomach neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -140944,7 +140944,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of pylorus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -140956,7 +140956,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of pylorus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -140968,7 +140968,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pylorus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141071,7 +141071,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of pyloric antrum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141083,13 +141083,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of pyloric antrum - MONDO:patterns/cancer + MONDO:patterns/cancer malignant pyloric antrum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141195,7 +141195,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cardia of stomach - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141207,14 +141207,14 @@ b) intends the object or event that the mental process is about, should such exi malignant cardia of stomach neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of cardia of stomach DOID:10548 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141484,7 +141484,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lymph node - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141497,14 +141497,14 @@ b) intends the object or event that the mental process is about, should such exi malignant lymph node neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C35812 malignant neoplasm of lymph node - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141723,13 +141723,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of broad ligament of uterus - MONDO:patterns/cancer + MONDO:patterns/cancer malignant broad ligament of uterus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -141737,7 +141737,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of broad ligament of uterus DOID:10744 ICD9CM:183.3 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -142541,13 +142541,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of nasal cavity - MONDO:patterns/cancer + MONDO:patterns/cancer malignant nasal cavity neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4918 @@ -142567,7 +142567,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of nasal cavity - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4918 @@ -143983,7 +143983,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -144019,7 +144019,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9334 @@ -144068,7 +144068,7 @@ b) intends the object or event that the mental process is about, should such exi malignant urinary bladder neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9334 @@ -144755,7 +144755,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of vermiform appendix - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -144793,7 +144793,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of vermiform appendix - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -144812,7 +144812,7 @@ b) intends the object or event that the mental process is about, should such exi malignant vermiform appendix neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -146506,14 +146506,14 @@ b) intends the object or event that the mental process is about, should such exi cancer of pericardium - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of pericardium DOID:116 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4567 @@ -146538,7 +146538,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pericardium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -146758,7 +146758,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of penis - MONDO:patterns/cancer + MONDO:patterns/cancer Orphanet:398043 @@ -146771,7 +146771,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of penis - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7547 @@ -146798,7 +146798,7 @@ b) intends the object or event that the mental process is about, should such exi malignant penis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147035,7 +147035,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of heart - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147061,7 +147061,7 @@ b) intends the object or event that the mental process is about, should such exi malignant heart neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3548 @@ -147075,7 +147075,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of heart DOID:117 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3548 @@ -147270,19 +147270,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of parametrium - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of parametrium - MONDO:patterns/cancer + MONDO:patterns/cancer malignant parametrium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147639,19 +147639,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of neck of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neck of urinary bladder neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of neck of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147749,7 +147749,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of trigone of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147757,13 +147757,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of trigone of urinary bladder DOID:11813 ICD9CM:188.0 - MONDO:patterns/cancer + MONDO:patterns/cancer malignant trigone of urinary bladder neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147857,13 +147857,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of urachus - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of urachus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147875,7 +147875,7 @@ b) intends the object or event that the mental process is about, should such exi malignant urachus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -147980,13 +147980,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of ureteral orifice - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of ureteral orifice - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148004,7 +148004,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ureteral orifice neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148117,7 +148117,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of fundus of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148129,7 +148129,7 @@ b) intends the object or event that the mental process is about, should such exi malignant fundus of urinary bladder neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148148,7 +148148,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of fundus of urinary bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148514,7 +148514,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of glans penis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148526,7 +148526,7 @@ b) intends the object or event that the mental process is about, should such exi malignant glans penis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -148534,7 +148534,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of glans penis DOID:11839 ICD9CM:187.2 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149026,7 +149026,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of vagina - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149040,7 +149040,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of vagina DOID:119 ICD9CM:184.0 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7410 @@ -149059,7 +149059,7 @@ b) intends the object or event that the mental process is about, should such exi malignant vagina neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7410 @@ -149210,7 +149210,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of labium majora - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149234,7 +149234,7 @@ b) intends the object or event that the mental process is about, should such exi malignant labium majora neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149248,7 +149248,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of labium majora - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149679,7 +149679,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of trachea - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -149692,7 +149692,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of trachea DOID:11920 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:NOCODE NCIT:C9346 @@ -149700,7 +149700,7 @@ b) intends the object or event that the mental process is about, should such exi malignant trachea neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9346 @@ -150012,7 +150012,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of female reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -150037,7 +150037,7 @@ b) intends the object or event that the mental process is about, should such exi malignant female reproductive organ neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -150074,7 +150074,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of female reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -151092,7 +151092,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of descending colon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -151104,13 +151104,13 @@ b) intends the object or event that the mental process is about, should such exi malignant descending colon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of descending colon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -151218,19 +151218,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of sigmoid colon - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sigmoid colon - MONDO:patterns/cancer + MONDO:patterns/cancer malignant sigmoid colon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -151573,19 +151573,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of intrahepatic bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer malignant intrahepatic bile duct neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of intrahepatic bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -152443,7 +152443,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of labium minora - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -152467,7 +152467,7 @@ b) intends the object or event that the mental process is about, should such exi malignant labium minora neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -152481,7 +152481,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of labium minora - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -152646,19 +152646,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of mammalian vulva - MONDO:patterns/cancer + MONDO:patterns/cancer malignant mammalian vulva neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of mammalian vulva - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -153461,7 +153461,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lacrimal drainage system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -153473,7 +153473,7 @@ b) intends the object or event that the mental process is about, should such exi malignant lacrimal drainage system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -153491,7 +153491,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of lacrimal drainage system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -154801,7 +154801,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of prepuce - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -154813,13 +154813,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of prepuce - MONDO:patterns/cancer + MONDO:patterns/cancer malignant prepuce neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -154934,13 +154934,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of spermatic cord - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of spermatic cord - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3559 @@ -154953,7 +154953,7 @@ b) intends the object or event that the mental process is about, should such exi malignant spermatic cord neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -155175,7 +155175,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of brain - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3568 @@ -155188,7 +155188,7 @@ b) intends the object or event that the mental process is about, should such exi malignant brain neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3568 @@ -155207,7 +155207,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of brain - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3568 @@ -155399,19 +155399,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of bronchus - MONDO:patterns/cancer + MONDO:patterns/cancer malignant bronchus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of bronchus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -155867,7 +155867,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of laryngeal cartilage - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -155879,13 +155879,13 @@ b) intends the object or event that the mental process is about, should such exi malignant laryngeal cartilage neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of laryngeal cartilage - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -156360,7 +156360,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of supraglottic part of larynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -156372,7 +156372,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of supraglottic part of larynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -156398,7 +156398,7 @@ b) intends the object or event that the mental process is about, should such exi malignant supraglottic part of larynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157063,7 +157063,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of maxillary sinus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157075,7 +157075,7 @@ b) intends the object or event that the mental process is about, should such exi malignant maxillary sinus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3540 @@ -157094,7 +157094,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of maxillary sinus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3540 @@ -157239,7 +157239,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of frontal sinus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157251,7 +157251,7 @@ b) intends the object or event that the mental process is about, should such exi malignant frontal sinus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157265,7 +157265,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of frontal sinus DOID:1360 ICD9CM:160.4 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:U001261 @@ -157529,7 +157529,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ethmoid sinus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157541,7 +157541,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ethmoid sinus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -157565,7 +157565,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ethmoid sinus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3541 @@ -159039,19 +159039,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of paraurethral gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of paraurethral gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant paraurethral gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -159380,7 +159380,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of anus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -159399,13 +159399,13 @@ b) intends the object or event that the mental process is about, should such exi malignant anus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of anus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7379 @@ -160633,20 +160633,20 @@ b) intends the object or event that the mental process is about, should such exi cancer of parietal lobe - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of parietal lobe DOID:14384 - MONDO:patterns/cancer + MONDO:patterns/cancer malignant parietal lobe neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -161198,7 +161198,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of sphenoidal sinus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -161210,7 +161210,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of sphenoidal sinus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3543 @@ -161241,7 +161241,7 @@ b) intends the object or event that the mental process is about, should such exi malignant sphenoidal sinus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3543 @@ -162559,13 +162559,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of caecum - MONDO:patterns/cancer + MONDO:patterns/cancer malignant caecum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -162584,7 +162584,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of caecum DOID:1521 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -164764,7 +164764,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of peritoneum DOID:1725 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -164776,7 +164776,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of peritoneum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -164788,7 +164788,7 @@ b) intends the object or event that the mental process is about, should such exi malignant peritoneum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165132,7 +165132,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of vasculature - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165150,7 +165150,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of vasculature - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165169,7 +165169,7 @@ b) intends the object or event that the mental process is about, should such exi malignant vasculature neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165473,7 +165473,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cardiovascular system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165491,13 +165491,13 @@ b) intends the object or event that the mental process is about, should such exi malignant cardiovascular system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of cardiovascular system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165960,7 +165960,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of thyroid gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -165986,14 +165986,14 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of thyroid gland DOID:1781 ICD9CM:193 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7510 malignant thyroid gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7510 @@ -166175,7 +166175,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of pituitary gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -166187,7 +166187,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of pituitary gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4769 @@ -166206,7 +166206,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pituitary gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4769 @@ -166538,7 +166538,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of exocrine pancreas - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -166550,7 +166550,7 @@ b) intends the object or event that the mental process is about, should such exi malignant exocrine pancreas neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7430 @@ -166563,7 +166563,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of exocrine pancreas - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7430 @@ -167237,7 +167237,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of skeletal element - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -167275,7 +167275,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of skeletal element - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -167300,7 +167300,7 @@ b) intends the object or event that the mental process is about, should such exi malignant skeletal element neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -167403,7 +167403,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of jaw skeleton - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -167415,13 +167415,13 @@ b) intends the object or event that the mental process is about, should such exi malignant jaw skeleton neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of jaw skeleton - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -167477,19 +167477,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of skull - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of skull - MONDO:patterns/cancer + MONDO:patterns/cancer malignant skull neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -168289,39 +168289,39 @@ b) intends the object or event that the mental process is about, should such exi cancer of reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer cancer of reproductive system DOID:193 - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of reproductive system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant reproductive organ neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant reproductive system neoplasm DOID:193 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C36076 @@ -168895,7 +168895,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of fallopian tube - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -168925,7 +168925,7 @@ b) intends the object or event that the mental process is about, should such exi malignant fallopian tube neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7480 @@ -168938,7 +168938,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of fallopian tube - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7480 @@ -169732,7 +169732,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of placenta - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -169746,7 +169746,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of placenta DOID:2021 ICD9CM:181 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -169758,7 +169758,7 @@ b) intends the object or event that the mental process is about, should such exi malignant placenta neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -170568,14 +170568,14 @@ b) intends the object or event that the mental process is about, should such exi cancer of sweat gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sweat gland DOID:2095 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4810 @@ -170588,7 +170588,7 @@ b) intends the object or event that the mental process is about, should such exi malignant sweat gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4810 @@ -170811,20 +170811,20 @@ b) intends the object or event that the mental process is about, should such exi cancer of temporal lobe - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of temporal lobe DOID:2135 - MONDO:patterns/cancer + MONDO:patterns/cancer malignant temporal lobe neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -171880,14 +171880,14 @@ b) intends the object or event that the mental process is about, should such exi cancer of eye - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4767 cancer of eyeball of camera-type eye - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -171913,7 +171913,7 @@ b) intends the object or event that the mental process is about, should such exi malignant eye neoplasm DOID:2174 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4767 @@ -171926,20 +171926,20 @@ b) intends the object or event that the mental process is about, should such exi malignant eyeball of camera-type eye neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of eye - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4767 malignant neoplasm of eyeball of camera-type eye - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -172077,19 +172077,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of ascending colon - MONDO:patterns/cancer + MONDO:patterns/cancer malignant ascending colon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of ascending colon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -174651,7 +174651,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of clitoris - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -174682,7 +174682,7 @@ b) intends the object or event that the mental process is about, should such exi malignant clitoris neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3557 @@ -174695,7 +174695,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of clitoris - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3557 @@ -176808,7 +176808,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of glottis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -176820,7 +176820,7 @@ b) intends the object or event that the mental process is about, should such exi malignant glottis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3544 @@ -176833,7 +176833,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of glottis - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3544 @@ -176981,7 +176981,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of larynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -177005,7 +177005,7 @@ b) intends the object or event that the mental process is about, should such exi malignant larynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7484 @@ -177018,7 +177018,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of larynx - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7484 @@ -177892,19 +177892,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of transverse colon - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of transverse colon - MONDO:patterns/cancer + MONDO:patterns/cancer malignant transverse colon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -178268,7 +178268,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of kidney - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -178280,7 +178280,7 @@ b) intends the object or event that the mental process is about, should such exi malignant kidney neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7548 @@ -178293,7 +178293,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of kidney - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7548 @@ -179944,7 +179944,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of rectosigmoid junction - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -179958,7 +179958,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of rectosigmoid junction DOID:2782 ICD9CM:154.0 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7420 @@ -179971,7 +179971,7 @@ b) intends the object or event that the mental process is about, should such exi malignant rectosigmoid junction neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -180236,7 +180236,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of vestibulocochlear nerve - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -180290,7 +180290,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of vestibulocochlear nerve - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4539 @@ -180346,7 +180346,7 @@ b) intends the object or event that the mental process is about, should such exi malignant vestibulocochlear nerve neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -180459,7 +180459,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cranial nerve - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -180477,7 +180477,7 @@ b) intends the object or event that the mental process is about, should such exi malignant cranial nerve neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3571 @@ -180491,7 +180491,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of cranial nerve DOID:2815 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3571 @@ -180587,7 +180587,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a oculomotor nerve. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -180628,19 +180628,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of oculomotor nerve - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of oculomotor nerve - MONDO:patterns/cancer + MONDO:patterns/cancer malignant oculomotor nerve neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -181497,7 +181497,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lacrimal apparatus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -181521,13 +181521,13 @@ b) intends the object or event that the mental process is about, should such exi malignant lacrimal apparatus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of lacrimal apparatus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -181924,7 +181924,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lacrimal gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -181936,7 +181936,7 @@ b) intends the object or event that the mental process is about, should such exi malignant lacrimal gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3563 @@ -181950,7 +181950,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of lacrimal gland DOID:294 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3563 @@ -184638,7 +184638,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of digestive system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -184664,7 +184664,7 @@ b) intends the object or event that the mental process is about, should such exi malignant digestive system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4890 @@ -184683,7 +184683,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of digestive system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -188165,7 +188165,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of thymus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -188195,13 +188195,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of thymus - MONDO:patterns/cancer + MONDO:patterns/cancer malignant thymus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -188318,19 +188318,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of notochord - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of notochord - MONDO:patterns/cancer + MONDO:patterns/cancer malignant notochord neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -191511,7 +191511,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of iris - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -191523,7 +191523,7 @@ b) intends the object or event that the mental process is about, should such exi malignant iris neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -191535,7 +191535,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of iris - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4554 @@ -191658,7 +191658,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of uvea - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -191670,7 +191670,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of uvea - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C6105 @@ -191690,7 +191690,7 @@ b) intends the object or event that the mental process is about, should such exi malignant uvea neoplasm DOID:3479 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C6105 @@ -192195,7 +192195,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of choroid plexus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -192207,7 +192207,7 @@ b) intends the object or event that the mental process is about, should such exi malignant choroid plexus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4533 @@ -192232,7 +192232,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of choroid plexus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4533 @@ -192383,7 +192383,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of brain ventricle - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -192444,13 +192444,13 @@ b) intends the object or event that the mental process is about, should such exi malignant brain ventricle neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of brain ventricle - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -193015,7 +193015,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of liver - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -193045,14 +193045,14 @@ b) intends the object or event that the mental process is about, should such exi malignant liver neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of liver DOID:3571 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -193637,7 +193637,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of central nervous system - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4627 @@ -193694,7 +193694,7 @@ b) intends the object or event that the mental process is about, should such exi malignant central nervous system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4627 @@ -193713,7 +193713,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of central nervous system - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4627 @@ -193898,7 +193898,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of uterus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3552 @@ -193912,7 +193912,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of uterus DOID:363 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3552 @@ -193944,7 +193944,7 @@ b) intends the object or event that the mental process is about, should such exi malignant uterus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -194995,13 +194995,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of cerebral hemisphere - MONDO:patterns/cancer + MONDO:patterns/cancer cancer of telencephalon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -195014,7 +195014,7 @@ b) intends the object or event that the mental process is about, should such exi malignant cerebral hemisphere neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -195044,7 +195044,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of cerebral hemisphere - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -195062,7 +195062,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of telencephalon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -195080,7 +195080,7 @@ b) intends the object or event that the mental process is about, should such exi malignant telencephalon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -196708,7 +196708,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a diencephalon. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -196735,7 +196735,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of diencephalon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -196767,13 +196767,13 @@ b) intends the object or event that the mental process is about, should such exi malignant diencephalon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of diencephalon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -197546,7 +197546,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of main bronchus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -197558,7 +197558,7 @@ b) intends the object or event that the mental process is about, should such exi malignant main bronchus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -197566,7 +197566,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of main bronchus DOID:3924 ICD9CM:162.2 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -197758,13 +197758,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of adipose tissue - MONDO:patterns/cancer + MONDO:patterns/cancer malignant adipose tissue neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4501 @@ -197789,7 +197789,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of adipose tissue - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4501 @@ -198246,13 +198246,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of adrenal gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant adrenal gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9338 @@ -198280,7 +198280,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of adrenal gland DOID:3953 ICD9CM:194.0 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9338 @@ -199244,7 +199244,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of skeletal muscle tissue - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -199256,7 +199256,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of skeletal muscle tissue - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -199274,7 +199274,7 @@ b) intends the object or event that the mental process is about, should such exi malignant skeletal muscle tissue neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -200782,7 +200782,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of orbit of skull - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -200795,7 +200795,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of orbit of skull - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -200813,7 +200813,7 @@ b) intends the object or event that the mental process is about, should such exi malignant orbit of skull neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -200998,7 +200998,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of zone of skin - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -201018,7 +201018,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of zone of skin - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -201048,7 +201048,7 @@ b) intends the object or event that the mental process is about, should such exi malignant zone of skin neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -201559,7 +201559,7 @@ b) intends the object or event that the mental process is about, should such exi malignant brainstem neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3570 @@ -201663,7 +201663,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of brainstem - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -201677,7 +201677,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of brainstem DOID:4203 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3570 @@ -203697,7 +203697,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ciliary body - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -203709,7 +203709,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ciliary body neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4766 @@ -203723,7 +203723,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ciliary body DOID:4352 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4766 @@ -204016,7 +204016,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of uterine cervix - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -204107,7 +204107,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of uterine cervix - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9311 @@ -204150,7 +204150,7 @@ b) intends the object or event that the mental process is about, should such exi malignant uterine cervix neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9311 @@ -206053,19 +206053,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer malignant bile duct neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -206143,19 +206143,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of biliary tree - MONDO:patterns/cancer + MONDO:patterns/cancer malignant biliary tree neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of biliary tree - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -206907,14 +206907,14 @@ b) intends the object or event that the mental process is about, should such exi cancer of retina - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of retina DOID:4645 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3216 @@ -206927,7 +206927,7 @@ b) intends the object or event that the mental process is about, should such exi malignant retina neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3216 @@ -207890,7 +207890,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of epicardium - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -207915,14 +207915,14 @@ b) intends the object or event that the mental process is about, should such exi malignant epicardium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of epicardium DOID:4699 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4568 @@ -211922,7 +211922,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of apocrine sweat gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -211958,7 +211958,7 @@ b) intends the object or event that the mental process is about, should such exi malignant apocrine sweat gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -211983,7 +211983,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of apocrine sweat gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -213321,13 +213321,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of pineal body - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of pineal body - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -213357,7 +213357,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pineal body neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -213985,13 +213985,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of sternum - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sternum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C8408 @@ -214017,7 +214017,7 @@ b) intends the object or event that the mental process is about, should such exi malignant sternum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214164,7 +214164,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of thoracic segment of trunk - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214176,7 +214176,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of thoracic segment of trunk - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214194,7 +214194,7 @@ b) intends the object or event that the mental process is about, should such exi malignant thoracic segment of trunk neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214315,7 +214315,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of middle ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214327,13 +214327,13 @@ b) intends the object or event that the mental process is about, should such exi malignant middle ear neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of middle ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214615,7 +214615,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214639,7 +214639,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ear neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214651,7 +214651,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214747,7 +214747,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of internal ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -214759,13 +214759,13 @@ b) intends the object or event that the mental process is about, should such exi malignant internal ear neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of internal ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -215498,7 +215498,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of dermis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -215516,7 +215516,7 @@ b) intends the object or event that the mental process is about, should such exi malignant dermis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4574 @@ -215530,7 +215530,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of dermis DOID:5274 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4574 @@ -217654,7 +217654,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of conjunctiva - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -217701,7 +217701,7 @@ b) intends the object or event that the mental process is about, should such exi malignant conjunctiva neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3564 @@ -217728,7 +217728,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of conjunctiva DOID:5467 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3564 @@ -219535,7 +219535,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a femur. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -219579,7 +219579,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of femur - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -219591,13 +219591,13 @@ b) intends the object or event that the mental process is about, should such exi malignant femur neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of femur - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -220039,13 +220039,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of spinal cord - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of spinal cord - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3572 @@ -220058,7 +220058,7 @@ b) intends the object or event that the mental process is about, should such exi malignant spinal cord neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3572 @@ -220726,7 +220726,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of external ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -220750,7 +220750,7 @@ b) intends the object or event that the mental process is about, should such exi malignant external ear neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -220762,7 +220762,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of external ear - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -221046,13 +221046,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of adrenal medulla - MONDO:patterns/cancer + MONDO:patterns/cancer malignant adrenal medulla neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4396 @@ -221066,7 +221066,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of adrenal medulla DOID:5719 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4396 @@ -221235,19 +221235,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of uterine ligament - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of uterine ligament - MONDO:patterns/cancer + MONDO:patterns/cancer malignant uterine ligament neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C126498 @@ -224041,7 +224041,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of endocardium - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -224066,14 +224066,14 @@ b) intends the object or event that the mental process is about, should such exi malignant endocardium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of endocardium DOID:5877 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4570 @@ -225593,7 +225593,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of leptomeninx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -225617,13 +225617,13 @@ b) intends the object or event that the mental process is about, should such exi malignant leptomeninx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of leptomeninx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -225718,7 +225718,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a dorsal plus ventral thalamus. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -225752,7 +225752,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of dorsal plus ventral thalamus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -225764,13 +225764,13 @@ b) intends the object or event that the mental process is about, should such exi malignant dorsal plus ventral thalamus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of dorsal plus ventral thalamus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -227401,7 +227401,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cornea - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -227413,7 +227413,7 @@ b) intends the object or event that the mental process is about, should such exi malignant cornea neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3565 @@ -227440,7 +227440,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of cornea DOID:6199 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3565 @@ -233989,19 +233989,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of meninx of spinal cord - MONDO:patterns/cancer + MONDO:patterns/cancer malignant meninx of spinal cord neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of meninx of spinal cord - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235009,7 +235009,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of urethra DOID:734 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235021,7 +235021,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of urethra - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7507 @@ -235046,7 +235046,7 @@ b) intends the object or event that the mental process is about, should such exi malignant urethra neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7507 @@ -235138,7 +235138,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a male urethra. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235171,7 +235171,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of male urethra - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235183,13 +235183,13 @@ b) intends the object or event that the mental process is about, should such exi malignant male urethra neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of male urethra - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235346,7 +235346,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of female urethra - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -235364,13 +235364,13 @@ b) intends the object or event that the mental process is about, should such exi malignant female urethra neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of female urethra - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -237197,19 +237197,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of retinal cell - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of retinal cell - MONDO:patterns/cancer + MONDO:patterns/cancer malignant retinal cell neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -239017,7 +239017,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of epiglottis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -239066,7 +239066,7 @@ b) intends the object or event that the mental process is about, should such exi malignant epiglottis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -239085,7 +239085,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of epiglottis DOID:8133 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -240032,19 +240032,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of auditory system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant auditory system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of auditory system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -240129,13 +240129,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of aorta - MONDO:patterns/cancer + MONDO:patterns/cancer malignant aorta neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -240147,7 +240147,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of aorta - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C5375 @@ -240723,7 +240723,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of oropharynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -240743,7 +240743,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of oropharynx DOID:8557 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:NOCODE NCIT:C7398 @@ -240776,7 +240776,7 @@ b) intends the object or event that the mental process is about, should such exi malignant oropharynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -241071,13 +241071,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of soft palate - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of soft palate - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3529 @@ -241090,7 +241090,7 @@ b) intends the object or event that the mental process is about, should such exi malignant soft palate neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3529 @@ -241171,7 +241171,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a gingiva of upper jaw. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -241205,7 +241205,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of gingiva of upper jaw - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -241217,13 +241217,13 @@ b) intends the object or event that the mental process is about, should such exi malignant gingiva of upper jaw neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of gingiva of upper jaw - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -241386,19 +241386,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of upper lip - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of upper lip - MONDO:patterns/cancer + MONDO:patterns/cancer malignant upper lip neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -241509,19 +241509,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of palatine uvula - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of palatine uvula - MONDO:patterns/cancer + MONDO:patterns/cancer malignant palatine uvula neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -242027,7 +242027,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of tongue - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -242035,7 +242035,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of tongue DOID:8649 ICD9CM:141 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:NOCODE NCIT:C9345 @@ -242043,7 +242043,7 @@ b) intends the object or event that the mental process is about, should such exi malignant tongue neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9345 @@ -242816,13 +242816,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of sublingual gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sublingual gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3527 @@ -242835,7 +242835,7 @@ b) intends the object or event that the mental process is about, should such exi malignant sublingual gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3527 @@ -242973,7 +242973,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of saliva-secreting gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -242991,7 +242991,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of saliva-secreting gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243015,7 +243015,7 @@ b) intends the object or event that the mental process is about, should such exi malignant saliva-secreting gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243237,7 +243237,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lower lip - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243249,13 +243249,13 @@ b) intends the object or event that the mental process is about, should such exi malignant lower lip neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of lower lip - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243361,7 +243361,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of tonsillar ring - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243373,13 +243373,13 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of tonsillar ring - MONDO:patterns/cancer + MONDO:patterns/cancer malignant tonsillar ring neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -243754,7 +243754,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of parotid gland DOID:9036 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3525 @@ -243779,7 +243779,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of parotid gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3525 @@ -243799,7 +243799,7 @@ b) intends the object or event that the mental process is about, should such exi malignant parotid gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3525 @@ -244254,7 +244254,7 @@ b) intends the object or event that the mental process is about, should such exi A cancer involving a gingiva of lower jaw. - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244288,7 +244288,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of gingiva of lower jaw - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244300,13 +244300,13 @@ b) intends the object or event that the mental process is about, should such exi malignant gingiva of lower jaw neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of gingiva of lower jaw - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244432,7 +244432,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of hard palate - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244451,7 +244451,7 @@ b) intends the object or event that the mental process is about, should such exi malignant hard palate neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244464,7 +244464,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of hard palate DOID:9149 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:U001235 @@ -244740,7 +244740,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of submandibular gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244758,7 +244758,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of submandibular gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244770,7 +244770,7 @@ b) intends the object or event that the mental process is about, should such exi malignant submandibular gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244893,13 +244893,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of oral opening - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of oral opening - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -244911,7 +244911,7 @@ b) intends the object or event that the mental process is about, should such exi malignant oral opening neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -245592,7 +245592,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of myocardium - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -245611,14 +245611,14 @@ b) intends the object or event that the mental process is about, should such exi malignant myocardium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of myocardium DOID:9299 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4569 @@ -250460,7 +250460,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of fundus of stomach - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -250478,7 +250478,7 @@ b) intends the object or event that the mental process is about, should such exi malignant fundus of stomach neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -250486,7 +250486,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of fundus of stomach DOID:10538 ICD9CM:151.3 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -273899,7 +273899,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of gall bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -273924,7 +273924,7 @@ b) intends the object or event that the mental process is about, should such exi malignant gall bladder neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -273942,7 +273942,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of gall bladder - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -274293,13 +274293,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of testis - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of testis - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7251 @@ -274324,7 +274324,7 @@ b) intends the object or event that the mental process is about, should such exi malignant testis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275669,7 +275669,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of eccrine sweat gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275712,7 +275712,7 @@ b) intends the object or event that the mental process is about, should such exi malignant eccrine sweat gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275737,7 +275737,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of eccrine sweat gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275884,7 +275884,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of gingiva - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275896,7 +275896,7 @@ b) intends the object or event that the mental process is about, should such exi malignant gingiva neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -275927,7 +275927,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of gingiva - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9317 @@ -276149,7 +276149,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of oral cavity - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -276173,7 +276173,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of oral cavity - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -276185,7 +276185,7 @@ b) intends the object or event that the mental process is about, should such exi malignant oral cavity neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9314 @@ -276371,31 +276371,31 @@ b) intends the object or event that the mental process is about, should such exi cancer of chordate pharynx - MONDO:patterns/cancer + MONDO:patterns/cancer cancer of pharynx - MONDO:patterns/cancer + MONDO:patterns/cancer malignant chordate pharynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of chordate pharynx - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of pharynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -276413,7 +276413,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pharynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7545 @@ -276519,7 +276519,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of renal pelvis - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -276527,14 +276527,14 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of renal pelvis DOID:4919 ICD9CM:189.1 - MONDO:patterns/cancer + MONDO:patterns/cancer malignant renal pelvis neoplasm DOID:4919 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7525 @@ -279467,7 +279467,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of colorectum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -279565,7 +279565,7 @@ b) intends the object or event that the mental process is about, should such exi malignant colorectum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -279595,7 +279595,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of colorectum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -281673,7 +281673,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of craniocervical region - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -281703,13 +281703,13 @@ b) intends the object or event that the mental process is about, should such exi head and neck malignant neoplasia - MONDO:patterns/cancer + MONDO:patterns/cancer malignant craniocervical region neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -281727,7 +281727,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of craniocervical region - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -283578,7 +283578,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of intestine - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4572 @@ -283640,7 +283640,7 @@ b) intends the object or event that the mental process is about, should such exi malignant intestine neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4572 @@ -283654,7 +283654,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of intestine DOID:10155 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4572 @@ -284405,7 +284405,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of male reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -284435,7 +284435,7 @@ b) intends the object or event that the mental process is about, should such exi malignant male reproductive organ neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -284472,7 +284472,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of male reproductive organ - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -284627,13 +284627,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of mandible - MONDO:patterns/cancer + MONDO:patterns/cancer malignant mandible neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -284653,7 +284653,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of mandible DOID:2338 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -285019,7 +285019,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of mediastinum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3549 @@ -285044,13 +285044,13 @@ b) intends the object or event that the mental process is about, should such exi malignant mediastinum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of mediastinum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3549 @@ -285307,7 +285307,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of muscle structure - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -285319,7 +285319,7 @@ b) intends the object or event that the mental process is about, should such exi malignant muscle structure neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -285338,7 +285338,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of muscle structure - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -285525,14 +285525,14 @@ b) intends the object or event that the mental process is about, should such exi cancer of nervous system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of nervous system DOID:3093 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4788 @@ -285545,7 +285545,7 @@ b) intends the object or event that the mental process is about, should such exi malignant nervous system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4788 @@ -286782,13 +286782,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of retroperitoneal space - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of retroperitoneal space - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -286807,7 +286807,7 @@ b) intends the object or event that the mental process is about, should such exi malignant retroperitoneal space neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -287188,7 +287188,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of spleen - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -287200,7 +287200,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of spleen - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3539 @@ -287213,7 +287213,7 @@ b) intends the object or event that the mental process is about, should such exi malignant spleen neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -295988,7 +295988,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of germ cell - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -296006,7 +296006,7 @@ b) intends the object or event that the mental process is about, should such exi malignant germ cell neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4925 @@ -296019,7 +296019,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of germ cell - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4925 @@ -296130,7 +296130,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of jugular body - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -296154,7 +296154,7 @@ b) intends the object or event that the mental process is about, should such exi malignant jugular body neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -296172,7 +296172,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of jugular body - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -296356,7 +296356,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of pleura - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3547 @@ -296369,7 +296369,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of pleura - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3547 @@ -296382,7 +296382,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pleura neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -296529,19 +296529,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of renal system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of renal system - MONDO:patterns/cancer + MONDO:patterns/cancer malignant renal system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -299830,7 +299830,7 @@ b) intends the object or event that the mental process is about, should such exi EFO:1000647 MESH:D015499 MONDO:Redundant - MONDO:indirect + MONDO:indirect @@ -300314,7 +300314,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of rectum DOID:1993 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -300322,7 +300322,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of rectum DOID:1993 ICD9CM:154.1 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7418 @@ -300348,7 +300348,7 @@ b) intends the object or event that the mental process is about, should such exi malignant rectum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -302981,7 +302981,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of optic choroid - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -303005,7 +303005,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of optic choroid - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -303017,7 +303017,7 @@ b) intends the object or event that the mental process is about, should such exi malignant optic choroid neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -304709,7 +304709,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of jejunum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -304721,7 +304721,7 @@ b) intends the object or event that the mental process is about, should such exi malignant jejunum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -304729,7 +304729,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of jejunum DOID:13499 ICD9CM:152.1 - MONDO:patterns/cancer + MONDO:patterns/cancer MTH:U001249 @@ -305324,7 +305324,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lip - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -305348,7 +305348,7 @@ b) intends the object or event that the mental process is about, should such exi malignant lip neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -305378,7 +305378,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of lip - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -308937,7 +308937,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of tonsil - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -309025,7 +309025,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of tonsil - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7404 @@ -309038,7 +309038,7 @@ b) intends the object or event that the mental process is about, should such exi malignant tonsil neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7404 @@ -310605,13 +310605,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of breast - MONDO:patterns/cancer + MONDO:patterns/cancer malignant breast neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9335 @@ -310625,7 +310625,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of breast DOID:1612 - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9335 @@ -311228,7 +311228,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of esophagus - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -311280,7 +311280,7 @@ b) intends the object or event that the mental process is about, should such exi malignant esophagus neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -311292,7 +311292,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of esophagus - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7478 @@ -313302,7 +313302,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ovary - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7431 @@ -313315,7 +313315,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ovary - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7431 @@ -313341,7 +313341,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ovary neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -314180,7 +314180,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of prostate gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -314192,7 +314192,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of prostate gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -314204,7 +314204,7 @@ b) intends the object or event that the mental process is about, should such exi malignant prostate gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -314846,7 +314846,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of ureter - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -314858,7 +314858,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of ureter - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7543 @@ -314883,7 +314883,7 @@ b) intends the object or event that the mental process is about, should such exi malignant ureter neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7543 @@ -315329,7 +315329,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of lung - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -315369,7 +315369,7 @@ b) intends the object or event that the mental process is about, should such exi malignant lung neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -315381,7 +315381,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of lung - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7377 @@ -316432,7 +316432,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of pancreas - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -316450,7 +316450,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of pancreas - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9005 @@ -316469,7 +316469,7 @@ b) intends the object or event that the mental process is about, should such exi malignant pancreas neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -318827,7 +318827,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of endometrium - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -318879,14 +318879,14 @@ b) intends the object or event that the mental process is about, should such exi malignant endometrium neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of endometrium DOID:1380 - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -352839,19 +352839,19 @@ b) intends the object or event that the mental process is about, should such exi cancer of skin of eyelid - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of skin of eyelid - MONDO:patterns/cancer + MONDO:patterns/cancer malignant skin of eyelid neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -358353,7 +358353,7 @@ b) intends the object or event that the mental process is about, should such exi MONDO:Redundant MONDO:cjm - MONDO:indirect + MONDO:indirect @@ -358517,7 +358517,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of colon - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -358541,7 +358541,7 @@ b) intends the object or event that the mental process is about, should such exi malignant colon neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9242 @@ -358566,7 +358566,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of colon - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9242 @@ -359490,7 +359490,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of endocrine gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -359514,7 +359514,7 @@ b) intends the object or event that the mental process is about, should such exi malignant endocrine gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3575 @@ -359539,7 +359539,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of endocrine gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3575 @@ -361050,7 +361050,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of peripheral nervous system - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -361080,7 +361080,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of peripheral nervous system - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4961 @@ -361123,7 +361123,7 @@ b) intends the object or event that the mental process is about, should such exi malignant peripheral nervous system neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4961 @@ -362348,13 +362348,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of scrotum - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of scrotum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3560 @@ -362379,7 +362379,7 @@ b) intends the object or event that the mental process is about, should such exi malignant scrotum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -363325,13 +363325,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of bone marrow - MONDO:patterns/cancer + MONDO:patterns/cancer malignant bone marrow neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C35501 @@ -363344,7 +363344,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of bone marrow - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -365016,7 +365016,7 @@ b) intends the object or event that the mental process is about, should such exi MESH:D025861 MONDO:Redundant MONDO:cjm - MONDO:indirect + MONDO:indirect @@ -371075,7 +371075,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of endocervix - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371099,7 +371099,7 @@ b) intends the object or event that the mental process is about, should such exi malignant endocervix neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3553 @@ -371112,7 +371112,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of endocervix - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371249,7 +371249,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of neck - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4940 @@ -371262,7 +371262,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neck neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4940 @@ -371275,7 +371275,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of neck - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4940 @@ -371383,7 +371383,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of parathyroid gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371395,7 +371395,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of parathyroid gland - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371413,7 +371413,7 @@ b) intends the object or event that the mental process is about, should such exi malignant parathyroid gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9322 @@ -371536,13 +371536,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of adrenal cortex - MONDO:patterns/cancer + MONDO:patterns/cancer malignant adrenal cortex neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C9327 @@ -371567,7 +371567,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of adrenal cortex - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371662,7 +371662,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of eyelid - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371674,7 +371674,7 @@ b) intends the object or event that the mental process is about, should such exi malignant eyelid neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C6786 @@ -371687,7 +371687,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of eyelid - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C6786 @@ -371806,7 +371806,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of nasopharynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371824,13 +371824,13 @@ b) intends the object or event that the mental process is about, should such exi malignant nasopharynx neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of nasopharynx - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -371925,13 +371925,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of minor salivary gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant minor salivary gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4410 @@ -371944,7 +371944,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of minor salivary gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4410 @@ -372051,7 +372051,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of cerebellum - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372105,13 +372105,13 @@ b) intends the object or event that the mental process is about, should such exi malignant cerebellum neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of cerebellum - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C3569 @@ -372224,7 +372224,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of mouth floor - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372254,7 +372254,7 @@ b) intends the object or event that the mental process is about, should such exi malignant mouth floor neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372266,7 +372266,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of mouth floor - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372381,13 +372381,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of extrahepatic bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer malignant extrahepatic bile duct neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7483 @@ -372400,7 +372400,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of extrahepatic bile duct - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7483 @@ -372504,7 +372504,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of meningeal cluster - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372522,7 +372522,7 @@ b) intends the object or event that the mental process is about, should such exi malignant meningeal cluster neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372552,7 +372552,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of meningeal cluster - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372677,7 +372677,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of chest wall - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -372689,7 +372689,7 @@ b) intends the object or event that the mental process is about, should such exi malignant chest wall neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4580 @@ -372702,7 +372702,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of chest wall - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -395865,7 +395865,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of limb bone - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -395877,13 +395877,13 @@ b) intends the object or event that the mental process is about, should such exi malignant limb bone neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of limb bone - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -403335,7 +403335,7 @@ b) intends the object or event that the mental process is about, should such exi EFO:0005809 - MONDO:indirect + MONDO:indirect @@ -404740,13 +404740,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of sebaceous gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of sebaceous gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C8409 @@ -404759,7 +404759,7 @@ b) intends the object or event that the mental process is about, should such exi malignant sebaceous gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C8409 @@ -405697,7 +405697,7 @@ b) intends the object or event that the mental process is about, should such exi cancer of great vessel of heart - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -405715,7 +405715,7 @@ b) intends the object or event that the mental process is about, should such exi malignant great vessel of heart neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -405727,7 +405727,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of great vessel of heart - MONDO:patterns/cancer + MONDO:patterns/cancer @@ -409401,13 +409401,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of major salivary gland - MONDO:patterns/cancer + MONDO:patterns/cancer malignant major salivary gland neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4762 @@ -409420,7 +409420,7 @@ b) intends the object or event that the mental process is about, should such exi malignant neoplasm of major salivary gland - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C4762 @@ -410393,13 +410393,13 @@ b) intends the object or event that the mental process is about, should such exi cancer of renal pelvis - MONDO:patterns/cancer + MONDO:patterns/cancer malignant neoplasm of renal pelvis - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7525 @@ -410412,7 +410412,7 @@ b) intends the object or event that the mental process is about, should such exi malignant renal pelvis neoplasm - MONDO:patterns/cancer + MONDO:patterns/cancer NCIT:C7525 diff --git a/src/ontology/imports/nbo_import.owl b/src/ontology/imports/nbo_import.owl index b2b9e612..79a6e45d 100644 --- a/src/ontology/imports/nbo_import.owl +++ b/src/ontology/imports/nbo_import.owl @@ -18,14 +18,15 @@ xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#" xmlns:swrlb="http://www.w3.org/2003/11/swrlb#" xmlns:terms="http://purl.org/dc/terms/" - xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#3" - xmlns:chebi3="http://purl.obolibrary.org/obo/chebi#1" + xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#" + xmlns:chebi3="http://purl.obolibrary.org/obo/chebi#3" + xmlns:chebi4="http://purl.obolibrary.org/obo/chebi#1" xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2022-01-19 + 2022-08-03 @@ -336,6 +337,22 @@ + + + + + + + + + + + + + + + + @@ -592,6 +609,78 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -777,6 +866,12 @@ + + + + + + @@ -945,9 +1040,7 @@ - - shorthand - + @@ -4104,6 +4197,18 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + chebi_ontology + is_enantiomer_of + true + false + is enantiomer of + + + + @@ -4755,6 +4860,36 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 + SNICXCGAKADSCV-UHFFFAOYSA-N + 162.232 + 162.11570 + C=1C=C(C2N(CCC2)C)C=NC1 + 3-(1-methylpyrrolidin-2-yl)pyridine + chebi_ontology + CHEBI:138000 + + 3-(1-methylpyrrolidin-2-yl)pyridine + + + + + 3-(1-methylpyrrolidin-2-yl)pyridine + IUPAC + + + + + @@ -6521,521 +6656,2477 @@ For example, A and B may be gene products and binding of B by A positively regul - + - - - - - - + + + + - + - + - + - + - + - + - - + + - The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. + + + + + + + + + + + + + + + + + + + A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). 0 - CH4O - InChI=1S/CH4O/c1-2/h2H,1H3 - OKKJLVBELUTLKV-UHFFFAOYSA-N - 32.04186 - 32.02621 - CO - CHEBI:14588 - CHEBI:25227 - CHEBI:44080 - CHEBI:44553 - CHEBI:6816 - Beilstein:1098229 - CAS:67-56-1 - Gmelin:449 - HMDB:HMDB0001875 - KEGG:C00132 - KEGG:D02309 - MetaCyc:METOH - PDBeChem:MOH - PMID:11141607 - PMID:11430978 - PMID:11489599 - PMID:11680737 - PMID:11684179 - PMID:14012711 - PMID:14678513 - PMID:14760634 - PMID:15172721 - PMID:15906011 - PMID:16705261 - PMID:17451998 - PMID:17733096 - PMID:19064074 - PMID:19850112 - PMID:20314698 - Reaxys:1098229 - UM-BBD_compID:c0132 - Wikipedia:Methanol - METHANOL - Methanol - methanol + C17H19NO3 + InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 + BQJCRHHNABKAKU-KBQPJGBKSA-N + 285.33770 + 285.13649 + [H][C@]12C=C[C@H](O)[C@@H]3Oc4c(O)ccc5C[C@H]1N(C)CC[C@@]23c45 + CHEBI:14622 + CHEBI:25419 + CHEBI:44202 + CHEBI:7001 + Beilstein:93704 + CAS:57-27-2 + DrugBank:DB00295 + Drug_Central:1845 + KEGG:C01516 + KEGG:D08233 + KNApSAcK:C00001889 + MetaCyc:MORPHINE + PDB:1Q0Y + PDBeChem:MOI + PMID:12593758 + PMID:15019787 + PMID:17171884 + PMID:17667569 + PMID:19371311 + PMID:20071451 + PMID:23292329 + PMID:23325235 + PMID:23555556 + PMID:23927484 + PMID:23988259 + PMID:24096538 + PMID:24306419 + PMID:27735107 + PMID:27815868 + PMID:27866460 + PMID:29368335 + PMID:9231550 + Reaxys:93704 + VSDB:2982 + Wikipedia:Morphine + 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol + Morphine chebi_ontology - CH3OH - MeOH - Methyl alcohol - Methylalkohol - carbinol - spirit of wood - wood alcohol - wood naphtha - wood spirit - CHEBI:17790 + (-)-morphine + (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol + (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol + (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol + (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL + Morphia + Morphin + morfina + morphinum + morphium + CHEBI:17303 - methanol + morphine - + - Beilstein:1098229 + Beilstein:93704 Beilstein - + - CAS:67-56-1 + CAS:57-27-2 ChemIDplus - + - CAS:67-56-1 + CAS:57-27-2 KEGG COMPOUND - + - CAS:67-56-1 + CAS:57-27-2 NIST Chemistry WebBook - + - Gmelin:449 - Gmelin + Drug_Central:1845 + DrugCentral - + - PMID:11141607 + PMID:12593758 Europe PMC - + - PMID:11430978 + PMID:15019787 Europe PMC - + - PMID:11489599 + PMID:17171884 Europe PMC - + - PMID:11680737 + PMID:17667569 Europe PMC - + - PMID:11684179 + PMID:19371311 Europe PMC - + - PMID:14012711 + PMID:20071451 Europe PMC - + - PMID:14678513 + PMID:23292329 Europe PMC - + - PMID:14760634 + PMID:23325235 Europe PMC - + - PMID:15172721 + PMID:23555556 Europe PMC - + - PMID:15906011 + PMID:23927484 Europe PMC - + - PMID:16705261 + PMID:23988259 Europe PMC - + - PMID:17451998 + PMID:24096538 Europe PMC - + - PMID:17733096 + PMID:24306419 Europe PMC - + - PMID:19064074 + PMID:27735107 Europe PMC - + - PMID:19850112 + PMID:27815868 Europe PMC - + - PMID:20314698 + PMID:27866460 Europe PMC - + - Reaxys:1098229 - Reaxys + PMID:29368335 + Europe PMC - + - UM-BBD_compID:c0132 - UM-BBD - - - - - METHANOL - PDBeChem + PMID:9231550 + Europe PMC - - - Methanol - KEGG_COMPOUND + + + Reaxys:93704 + Reaxys - + - methanol + 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol IUPAC - + - methanol - UniProt + Morphine + KEGG_COMPOUND - + - CH3OH - ChEBI + (-)-morphine + ChemIDplus - + - MeOH - ChEBI + (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol + ChemIDplus - + - Methyl alcohol - KEGG_COMPOUND + (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol + ChEBI - + - Methylalkohol + (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol NIST_Chemistry_WebBook - - - carbinol - ChemIDplus - - - + - spirit of wood - HMDB + (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL + PDBeChem - + - wood alcohol + Morphia ChemIDplus - + - wood naphtha + Morphin ChemIDplus - + - wood spirit - NIST_Chemistry_WebBook - - - - - - - - - A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. - CHEBI:14202 - CHEBI:4697 - KEGG:C01351 - Donor - chebi_ontology - Donator - donneur - CHEBI:17891 - - donor - - - - - Donor - KEGG_COMPOUND + morfina + ChEBI - + - Donator - ChEBI + morphinum + ChemIDplus - + - donneur - ChEBI + morphium + ChemIDplus - + - - - + + - + - Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. - Wikipedia:Alkaloid - Alkaloid - alkaloids + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 + SNICXCGAKADSCV-JTQLQIEISA-N + 162.232 + 162.11570 + C=1C=C([C@]2(N(CCC2)C)[H])C=NC1 + CHEBI:14653 + CHEBI:25536 + CHEBI:44268 + CHEBI:7562 + BPDB:485 + Beilstein:3604351 + Beilstein:82109 + CAS:54-11-5 + DrugBank:DB00184 + Drug_Central:1920 + HMDB:HMDB0001934 + KEGG:C00745 + KEGG:D03365 + KNApSAcK:C00002057 + LINCS:LSM-2093 + MetaCyc:NICOTINE + PDBeChem:NCT + PMID:11209966 + PMID:11322615 + PMID:11406005 + PMID:11719700 + PMID:11768184 + PMID:11821649 + PMID:11851194 + PMID:12575980 + PMID:12692774 + PMID:12769614 + PMID:12850578 + PMID:12971663 + PMID:13590907 + PMID:14674846 + PMID:14761239 + PMID:14975706 + PMID:15019421 + PMID:15027713 + PMID:15251917 + PMID:15276225 + PMID:15380834 + PMID:15502843 + PMID:15527885 + PMID:15707677 + PMID:15734728 + PMID:15826609 + PMID:15894687 + PMID:15902919 + PMID:15960296 + PMID:15963341 + PMID:16059663 + PMID:16212709 + PMID:16333621 + PMID:16370520 + PMID:16496293 + PMID:17023324 + PMID:17206646 + PMID:17292347 + PMID:17350101 + PMID:17498763 + PMID:17504235 + PMID:17525204 + PMID:17560039 + PMID:17683794 + PMID:18380035 + PMID:18383130 + PMID:18490768 + PMID:18683238 + PMID:18685152 + PMID:18805442 + PMID:18922921 + PMID:19100291 + PMID:19100331 + PMID:19287496 + PMID:19389046 + PMID:19448649 + PMID:19465085 + PMID:19850423 + PMID:19954906 + PMID:21521420 + PMID:21636612 + PMID:21822688 + PMID:21945235 + PMID:21947355 + PMID:22030716 + PMID:22129149 + PMID:22218403 + PMID:22265518 + PMID:22331007 + PMID:22377934 + PMID:22459798 + PMID:22529223 + PMID:22530136 + PMID:27951416 + PMID:28187919 + PMID:28391535 + PMID:28574230 + PMID:28641297 + PMID:28678400 + PMID:28683421 + PMID:28686840 + PMID:28698187 + PMID:28700952 + PMID:28704277 + PMID:28710519 + PMID:28711472 + PMID:28714396 + PMID:28718768 + PMID:28718828 + PMID:28726253 + PMID:28735272 + Reaxys:82109 + Wikipedia:Nicotine + (S)-Nicotine + (S)-nicotine + 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine chebi_ontology - Alkaloide - alcaloide - alcaloides - CHEBI:22315 + (-)-3-(1-Methyl-2-pyrrolidyl)pyridine + (-)-3-(N-Methylpyrrolidino)pyridine + (-)-nicotine + (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine + (S)-(-)-nicotine + (S)-3-(1-methylpyrrolidin-2-yl)pyridine + (S)-3-(N-methylpyrrolidin-2-yl)pyridine + 1-Methyl-2-(3-pyridyl)pyrrolidine + 3-(1-Methyl-2-pyrollidinyl)pyridine + 3-(1-Methylpyrrolidin-2-yl)pyridine + 3-(2-(N-methylpyrrolidinyl))pyridine + 3-(N-methylpyrollidino)pyridine + L(-)-nicotine + L-3-(1-Methyl-2-pyrrolidyl)pyridine + L-Nicotine + Nicotine + CHEBI:17688 - alkaloid + (S)-nicotine - - - Alkaloid - ChEBI + + + Beilstein:3604351 + Beilstein - - - alkaloids - IUPAC - + + + Beilstein:82109 + Beilstein - - - Alkaloide - ChEBI + + + CAS:54-11-5 + ChemIDplus - - - alcaloide - ChEBI + + + CAS:54-11-5 + KEGG COMPOUND - - - alcaloides - ChEBI + + + CAS:54-11-5 + NIST Chemistry WebBook - - - - - - - - A monoatomic or polyatomic species having one or more elementary charges of the electron. - Anion - anion - chebi_ontology - Anionen - aniones - anions - CHEBI:22563 - - anion - - - - Anion - ChEBI + + + Drug_Central:1920 + DrugCentral - - - anion - ChEBI + + + PMID:11209966 + Europe PMC - - - anion - IUPAC - + + + PMID:11322615 + Europe PMC - - - Anionen - ChEBI + + + PMID:11406005 + Europe PMC - - - aniones - ChEBI + + + PMID:11719700 + Europe PMC - - - anions - IUPAC + + + PMID:11768184 + Europe PMC - - - - - - - - A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). - KEGG:C00701 - Base - base - chebi_ontology - Base1 - Base2 - Basen - Nucleobase - bases - CHEBI:22695 - - base - - - - Base - ChEBI + + + PMID:11821649 + Europe PMC - - - base - ChEBI + + + PMID:11851194 + Europe PMC - - - base - IUPAC - + + + PMID:12575980 + Europe PMC - + + + PMID:12692774 + Europe PMC + + + + + PMID:12769614 + Europe PMC + + + + + PMID:12850578 + Europe PMC + + + + + PMID:12971663 + Europe PMC + + + + + PMID:13590907 + Europe PMC + + + + + PMID:14674846 + Europe PMC + + + + + PMID:14761239 + Europe PMC + + + + + PMID:14975706 + Europe PMC + + + + + PMID:15019421 + Europe PMC + + + + + PMID:15027713 + Europe PMC + + + + + PMID:15251917 + Europe PMC + + + + + PMID:15276225 + Europe PMC + + + + + PMID:15380834 + Europe PMC + + + + + PMID:15502843 + Europe PMC + + + + + PMID:15527885 + Europe PMC + + + + + PMID:15707677 + Europe PMC + + + + + PMID:15734728 + Europe PMC + + + + + PMID:15826609 + Europe PMC + + + + + PMID:15894687 + Europe PMC + + + + + PMID:15902919 + Europe PMC + + + + + PMID:15960296 + Europe PMC + + + + + PMID:15963341 + Europe PMC + + + + + PMID:16059663 + Europe PMC + + + + + PMID:16212709 + Europe PMC + + + + + PMID:16333621 + Europe PMC + + + + + PMID:16370520 + Europe PMC + + + + + PMID:16496293 + Europe PMC + + + + + PMID:17023324 + Europe PMC + + + + + PMID:17206646 + Europe PMC + + + + + PMID:17292347 + Europe PMC + + + + + PMID:17350101 + Europe PMC + + + + + PMID:17498763 + Europe PMC + + + + + PMID:17504235 + Europe PMC + + + + + PMID:17525204 + Europe PMC + + + + + PMID:17560039 + Europe PMC + + + + + PMID:17683794 + Europe PMC + + + + + PMID:18380035 + Europe PMC + + + + + PMID:18383130 + Europe PMC + + + + + PMID:18490768 + Europe PMC + + + + + PMID:18683238 + Europe PMC + + + + + PMID:18685152 + Europe PMC + + + + + PMID:18805442 + Europe PMC + + + + + PMID:18922921 + Europe PMC + + + + + PMID:19100291 + Europe PMC + + + + + PMID:19100331 + Europe PMC + + + + + PMID:19287496 + Europe PMC + + + + + PMID:19389046 + Europe PMC + + + + + PMID:19448649 + Europe PMC + + + + + PMID:19465085 + Europe PMC + + + + + PMID:19850423 + Europe PMC + + + + + PMID:19954906 + Europe PMC + + + + + PMID:21521420 + Europe PMC + + + + + PMID:21636612 + Europe PMC + + + + + PMID:21822688 + Europe PMC + + + + + PMID:21945235 + Europe PMC + + + + + PMID:21947355 + Europe PMC + + + + + PMID:22030716 + Europe PMC + + + + + PMID:22129149 + Europe PMC + + + + + PMID:22218403 + Europe PMC + + + + + PMID:22265518 + Europe PMC + + + + + PMID:22331007 + Europe PMC + + + + + PMID:22377934 + Europe PMC + + + + + PMID:22459798 + Europe PMC + + + + + PMID:22529223 + Europe PMC + + + + + PMID:22530136 + Europe PMC + + + + + PMID:27951416 + Europe PMC + + + + + PMID:28187919 + Europe PMC + + + + + PMID:28391535 + Europe PMC + + + + + PMID:28574230 + Europe PMC + + + + + PMID:28641297 + Europe PMC + + + + + PMID:28678400 + Europe PMC + + + + + PMID:28683421 + Europe PMC + + + + + PMID:28686840 + Europe PMC + + + + + PMID:28698187 + Europe PMC + + + + + PMID:28700952 + Europe PMC + + + + + PMID:28704277 + Europe PMC + + + + + PMID:28710519 + Europe PMC + + + + + PMID:28711472 + Europe PMC + + + + + PMID:28714396 + Europe PMC + + + + + PMID:28718768 + Europe PMC + + + + + PMID:28718828 + Europe PMC + + + + + PMID:28726253 + Europe PMC + + + + + PMID:28735272 + Europe PMC + + + + + Reaxys:82109 + Reaxys + + + + + (S)-Nicotine + KEGG_COMPOUND + + + + + (S)-nicotine + ChemIDplus + + + + + 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine + IUPAC + + + + + + (-)-3-(1-Methyl-2-pyrrolidyl)pyridine + HMDB + + + + + (-)-3-(N-Methylpyrrolidino)pyridine + HMDB + + + + + (-)-nicotine + ChemIDplus + + + + + (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine + HMDB + + + + + (S)-(-)-nicotine + NIST_Chemistry_WebBook + + + + + (S)-3-(1-methylpyrrolidin-2-yl)pyridine + KEGG_COMPOUND + + + + + (S)-3-(N-methylpyrrolidin-2-yl)pyridine + IUBMB + + + + + 1-Methyl-2-(3-pyridyl)pyrrolidine + HMDB + + + + + 3-(1-Methyl-2-pyrollidinyl)pyridine + HMDB + + + + + 3-(1-Methylpyrrolidin-2-yl)pyridine + HMDB + + + + + 3-(2-(N-methylpyrrolidinyl))pyridine + NIST_Chemistry_WebBook + + + + + 3-(N-methylpyrollidino)pyridine + NIST_Chemistry_WebBook + + + + + L(-)-nicotine + IUBMB + + + + + L-3-(1-Methyl-2-pyrrolidyl)pyridine + HMDB + + + + + L-Nicotine + HMDB + + + + + Nicotine + HMDB + + + + + Nicotine + KEGG_COMPOUND + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. + 0 + CH4O + InChI=1S/CH4O/c1-2/h2H,1H3 + OKKJLVBELUTLKV-UHFFFAOYSA-N + 32.04186 + 32.02621 + CO + CHEBI:14588 + CHEBI:25227 + CHEBI:44080 + CHEBI:44553 + CHEBI:6816 + Beilstein:1098229 + CAS:67-56-1 + Gmelin:449 + HMDB:HMDB0001875 + KEGG:C00132 + KEGG:D02309 + MetaCyc:METOH + PDBeChem:MOH + PMID:11141607 + PMID:11430978 + PMID:11489599 + PMID:11680737 + PMID:11684179 + PMID:14012711 + PMID:14678513 + PMID:14760634 + PMID:15172721 + PMID:15906011 + PMID:16705261 + PMID:17451998 + PMID:17733096 + PMID:19064074 + PMID:19850112 + PMID:20314698 + Reaxys:1098229 + UM-BBD_compID:c0132 + Wikipedia:Methanol + METHANOL + Methanol + methanol + chebi_ontology + CH3OH + MeOH + Methyl alcohol + Methylalkohol + carbinol + spirit of wood + wood alcohol + wood naphtha + wood spirit + CHEBI:17790 + + methanol + + + + + Beilstein:1098229 + Beilstein + + + + + CAS:67-56-1 + ChemIDplus + + + + + CAS:67-56-1 + KEGG COMPOUND + + + + + CAS:67-56-1 + NIST Chemistry WebBook + + + + + Gmelin:449 + Gmelin + + + + + PMID:11141607 + Europe PMC + + + + + PMID:11430978 + Europe PMC + + + + + PMID:11489599 + Europe PMC + + + + + PMID:11680737 + Europe PMC + + + + + PMID:11684179 + Europe PMC + + + + + PMID:14012711 + Europe PMC + + + + + PMID:14678513 + Europe PMC + + + + + PMID:14760634 + Europe PMC + + + + + PMID:15172721 + Europe PMC + + + + + PMID:15906011 + Europe PMC + + + + + PMID:16705261 + Europe PMC + + + + + PMID:17451998 + Europe PMC + + + + + PMID:17733096 + Europe PMC + + + + + PMID:19064074 + Europe PMC + + + + + PMID:19850112 + Europe PMC + + + + + PMID:20314698 + Europe PMC + + + + + Reaxys:1098229 + Reaxys + + + + + UM-BBD_compID:c0132 + UM-BBD + + + + + METHANOL + PDBeChem + + + + + Methanol + KEGG_COMPOUND + + + + + methanol + IUPAC + + + + + + methanol + UniProt + + + + + CH3OH + ChEBI + + + + + MeOH + ChEBI + + + + + Methyl alcohol + KEGG_COMPOUND + + + + + Methylalkohol + NIST_Chemistry_WebBook + + + + + carbinol + ChemIDplus + + + + + spirit of wood + HMDB + + + + + wood alcohol + ChemIDplus + + + + + wood naphtha + ChemIDplus + + + + + wood spirit + NIST_Chemistry_WebBook + + + + + + + + + A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. + CHEBI:14202 + CHEBI:4697 + KEGG:C01351 + Donor + chebi_ontology + Donator + donneur + CHEBI:17891 + + donor + + + + + Donor + KEGG_COMPOUND + + + + + Donator + ChEBI + + + + + donneur + ChEBI + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A racemate composed of equimolar amounts of (R)- and (S)-nicotine. + Beilstein:82108 + Beilstein:82111 + CAS:22083-74-5 + DrugBank:DB00184 + HMDB:HMDB0014330 + KEGG:C16150 + KNApSAcK:C00002057 + PMID:10751565 + PMID:11192937 + PMID:11471991 + PMID:11559179 + PMID:11682702 + PMID:11714820 + PMID:11719700 + PMID:11801622 + PMID:11818389 + PMID:11860617 + PMID:12197757 + PMID:12700710 + PMID:12965231 + PMID:14715938 + PMID:15183514 + PMID:15251917 + PMID:15313135 + PMID:15458549 + PMID:15707677 + PMID:15894687 + PMID:15960296 + PMID:15961264 + PMID:16496293 + PMID:16950410 + PMID:17167832 + PMID:17206646 + PMID:17438652 + PMID:17498149 + PMID:17942810 + PMID:18077004 + PMID:18311975 + PMID:18380035 + PMID:18383130 + PMID:18651995 + PMID:18922921 + PMID:19100331 + PMID:19287496 + PMID:19389046 + PMID:19465085 + PMID:20338106 + PMID:20528766 + PMID:21636612 + PMID:21822688 + PMID:21945235 + PMID:22129149 + PMID:22218403 + PMID:22331007 + PMID:22377934 + PMID:22448647 + PMID:22459798 + PMID:22529223 + PMID:22573728 + PMID:22585541 + PMID:22589423 + PMID:22770225 + PMID:22792725 + PMID:22855884 + PMID:22930863 + PMID:22935730 + PMID:23108361 + PMID:23117126 + PMID:7097594 + PMID:7564279 + PMID:7566693 + PMID:7807214 + PMID:7896575 + PMID:8156919 + PMID:8545712 + PMID:8764340 + PMID:9203638 + PMID:9450943 + PMID:9621392 + Reaxys:82108 + UM-BBD_compID:c0468 + Wikipedia:Nicotine + rac-3-(1-methylpyrrolidin-2-yl)pyridine + chebi_ontology + (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine + (+-)-nicotine + (R,S)-nicotine + (RS)-nicotine + nicotin + nikotin + CHEBI:18723 + + nicotine + + + + + Beilstein:82108 + Beilstein + + + + + Beilstein:82111 + Beilstein + + + + + CAS:22083-74-5 + ChemIDplus + + + + + CAS:22083-74-5 + KEGG COMPOUND + + + + + PMID:10751565 + Europe PMC + + + + + PMID:11192937 + Europe PMC + + + + + PMID:11471991 + Europe PMC + + + + + PMID:11559179 + Europe PMC + + + + + PMID:11682702 + Europe PMC + + + + + PMID:11714820 + Europe PMC + + + + + PMID:11719700 + Europe PMC + + + + + PMID:11801622 + Europe PMC + + + + + PMID:11818389 + Europe PMC + + + + + PMID:11860617 + Europe PMC + + + + + PMID:12197757 + Europe PMC + + + + + PMID:12700710 + Europe PMC + + + + + PMID:12965231 + Europe PMC + + + + + PMID:14715938 + Europe PMC + + + + + PMID:15183514 + Europe PMC + + + + + PMID:15251917 + Europe PMC + + + + + PMID:15313135 + Europe PMC + + + + + PMID:15458549 + Europe PMC + + + + + PMID:15707677 + Europe PMC + + + + + PMID:15894687 + Europe PMC + + + + + PMID:15960296 + Europe PMC + + + + + PMID:15961264 + Europe PMC + + + + + PMID:16496293 + Europe PMC + + + + + PMID:16950410 + Europe PMC + + + + + PMID:17167832 + Europe PMC + + + + + PMID:17206646 + Europe PMC + + + + + PMID:17438652 + Europe PMC + + + + + PMID:17498149 + Europe PMC + + + + + PMID:17942810 + Europe PMC + + + + + PMID:18077004 + Europe PMC + + + + + PMID:18311975 + Europe PMC + + + + + PMID:18380035 + Europe PMC + + + + + PMID:18383130 + Europe PMC + + + + + PMID:18651995 + Europe PMC + + + + + PMID:18922921 + Europe PMC + + + + + PMID:19100331 + Europe PMC + + + + + PMID:19287496 + Europe PMC + + + + + PMID:19389046 + Europe PMC + + + + + PMID:19465085 + Europe PMC + + + + + PMID:20338106 + Europe PMC + + + + + PMID:20528766 + Europe PMC + + + + + PMID:21636612 + Europe PMC + + + + + PMID:21822688 + Europe PMC + + + + + PMID:21945235 + Europe PMC + + + + + PMID:22129149 + Europe PMC + + + + + PMID:22218403 + Europe PMC + + + + + PMID:22331007 + Europe PMC + + + + + PMID:22377934 + Europe PMC + + + + + PMID:22448647 + Europe PMC + + + + + PMID:22459798 + Europe PMC + + + + + PMID:22529223 + Europe PMC + + + + + PMID:22573728 + Europe PMC + + + + + PMID:22585541 + Europe PMC + + + + + PMID:22589423 + Europe PMC + + + + + PMID:22770225 + Europe PMC + + + + + PMID:22792725 + Europe PMC + + + + + PMID:22855884 + Europe PMC + + + + + PMID:22930863 + Europe PMC + + + + + PMID:22935730 + Europe PMC + + + + + PMID:23108361 + Europe PMC + + + + + PMID:23117126 + Europe PMC + + + + + PMID:7097594 + Europe PMC + + + + + PMID:7564279 + Europe PMC + + + + + PMID:7566693 + Europe PMC + + + + + PMID:7807214 + Europe PMC + + + + + PMID:7896575 + Europe PMC + + + + + PMID:8156919 + Europe PMC + + + + + PMID:8545712 + Europe PMC + + + + + PMID:8764340 + Europe PMC + + + + + PMID:9203638 + Europe PMC + + + + + PMID:9450943 + Europe PMC + + + + + PMID:9621392 + Europe PMC + + + + + Reaxys:82108 + Reaxys + + + + + UM-BBD_compID:c0468 + UM-BBD + + + + + rac-3-(1-methylpyrrolidin-2-yl)pyridine + IUPAC + + + + + + (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine + KEGG_COMPOUND + + + + + (+-)-nicotine + ChemIDplus + + + + + (R,S)-nicotine + ChemIDplus + + + + + (RS)-nicotine + UM-BBD + + + + + nicotin + ChEBI + + + + + nikotin + ChEBI + + + + + + + + + + + + + + + + Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. + Wikipedia:Alkaloid + Alkaloid + alkaloids + chebi_ontology + Alkaloide + alcaloide + alcaloides + CHEBI:22315 + + alkaloid + + + + + Alkaloid + ChEBI + + + + + alkaloids + IUPAC + + + + + + Alkaloide + ChEBI + + + + + alcaloide + ChEBI + + + + + alcaloides + ChEBI + + + + + + + + + A monoatomic or polyatomic species having one or more elementary charges of the electron. + Anion + anion + chebi_ontology + Anionen + aniones + anions + CHEBI:22563 + + anion + + + + + Anion + ChEBI + + + + + anion + ChEBI + + + + + anion + IUPAC + + + + + + Anionen + ChEBI + + + + + aniones + ChEBI + + + + + anions + IUPAC + + + + + + + + + A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). + KEGG:C00701 + Base + base + chebi_ontology + Base1 + Base2 + Basen + Nucleobase + bases + CHEBI:22695 + + base + + + + + Base + ChEBI + + + + + base + ChEBI + + + + + base + IUPAC + + + + Base1 KEGG_COMPOUND @@ -7094,6 +9185,40 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + An insecticide compound naturally occurring in plants. + chebi_ontology + botanical insecticide + botanical insecticides + phytogenic insecticides + CHEBI:22917 + + phytogenic insecticide + + + + + botanical insecticide + ChEBI + + + + + botanical insecticides + ChEBI + + + + + phytogenic insecticides + ChEBI + + + + @@ -7636,6 +9761,27 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. + Wikipedia:Insecticide + chebi_ontology + insecticides + CHEBI:24852 + + insecticide + + + + + insecticides + ChEBI + + + + @@ -7691,6 +9837,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine. + chebi_ontology + isoquinoline alkaloids + CHEBI:24921 + + isoquinoline alkaloid + + + + + isoquinoline alkaloids + ChEBI + + + + @@ -7821,6 +9987,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + An isoquinoline alkaloid based on a morphinan skeleton and its substituted derivatives. + chebi_ontology + morphinane alkaloids + CHEBI:25418 + + morphinane alkaloid + + + + + morphinane alkaloids + ChEBI + + + + @@ -7972,6 +10158,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + chebi_ontology + organic heteromonocyclic compounds + CHEBI:25693 + + organic heteromonocyclic compound + + + + + organic heteromonocyclic compounds + ChEBI + + + + @@ -7993,6 +10199,27 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + Any organic ion with a net positive charge. + chebi_ontology + organic cations + CHEBI:25697 + + organic cation + + + + + organic cations + ChEBI + + + + @@ -8192,6 +10419,103 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. + Wikipedia:Pesticide + pesticide + chebi_ontology + Pestizid + Pestizide + pesticides + CHEBI:25944 + + pesticide + + + + + pesticide + IUPAC + + + + + + Pestizid + ChEBI + + + + + Pestizide + ChEBI + + + + + pesticides + ChEBI + + + + + + + + + + chebi_ontology + pyridine alkaloids + CHEBI:26416 + + pyridine alkaloid + + + + + pyridine alkaloids + ChEBI + + + + + + + + + + Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives. + chebi_ontology + CHEBI:26421 + + pyridines + + + + + + + + + + chebi_ontology + pyrrolidine alkaloids + CHEBI:26456 + + pyrrolidine alkaloid + + + + + pyrrolidine alkaloids + ChEBI + + + + @@ -8940,6 +11264,24 @@ For example, A and B may be gene products and binding of B by A positively regul ammonium + + + + NH4+ + KEGG_COMPOUND + + + + + [NH4](+) + MolBase + + + + + ammonium ion + PDBeChem + @@ -9110,24 +11452,6 @@ For example, A and B may be gene products and binding of B by A positively regul NH4(+) UniProt - - - - NH4+ - KEGG_COMPOUND - - - - - [NH4](+) - MolBase - - - - - ammonium ion - PDBeChem - @@ -9834,6 +12158,34 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system. + chebi_ontology + organic fundamental parents + organic parent hydrides + CHEBI:33245 + + organic fundamental parent + + + + + organic fundamental parents + ChEBI + + + + + organic parent hydrides + ChEBI + + + + @@ -11334,6 +13686,54 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + chebi_ontology + monocyclic compounds + CHEBI:33661 + + monocyclic compound + + + + + monocyclic compounds + ChEBI + + + + + + + + + + heteromonocyclic compound + heteromonocyclic compounds + chebi_ontology + CHEBI:33670 + + heteromonocyclic compound + + + + + heteromonocyclic compound + IUPAC + + + + + + heteromonocyclic compounds + IUPAC + + + + + @@ -12043,6 +14443,221 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A loosely defined grouping of drugs that have effects on psychological function. + Wikipedia:Psychotropic_drug + chebi_ontology + psychoactive agent + psychoactive drugs + psychopharmaceuticals + psychotropic drugs + CHEBI:35471 + + psychotropic drug + + + + + psychoactive agent + ChEBI + + + + + psychoactive drugs + ChEBI + + + + + psychopharmaceuticals + ChEBI + + + + + psychotropic drugs + ChEBI + + + + + + + + + + A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour. + chebi_ontology + ataractics + tranquilising drug + tranquilizing drugs + tranquillising agent + tranquillizing agents + CHEBI:35473 + + tranquilizing drug + + + + + ataractics + ChEBI + + + + + tranquilising drug + ChEBI + + + + + tranquilizing drugs + ChEBI + + + + + tranquillising agent + ChEBI + + + + + tranquillizing agents + ChEBI + + + + + + + + + Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. + chebi_ontology + anti-anxiety agents + anti-anxiety drugs + anxiolytic agents + anxiolytics + minor tranquilisers + minor tranquilizers + minor tranquilizing agents + CHEBI:35474 + + anxiolytic drug + + + + + anti-anxiety agents + ChEBI + + + + + anti-anxiety drugs + ChEBI + + + + + anxiolytic agents + ChEBI + + + + + anxiolytics + ChEBI + + + + + minor tranquilisers + ChEBI + + + + + minor tranquilizers + ChEBI + + + + + minor tranquilizing agents + ChEBI + + + + + + + + + + An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. + chebi_ontology + CHEBI:35480 + + analgesic + + + + + + + + + A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. + chebi_ontology + narcotic + narcotic analgesic + narcotic analgesics + narcotics + opioid analgesics + CHEBI:35482 + + opioid analgesic + + + + + narcotic + ChEBI + + + + + narcotic analgesic + ChEBI + + + + + narcotic analgesics + ChEBI + + + + + narcotics + ChEBI + + + + + opioid analgesics + ChEBI + + + + @@ -12070,6 +14685,45 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + chebi_ontology + alkaloid fundamental parents + CHEBI:35506 + + alkaloid fundamental parent + + + + + alkaloid fundamental parents + ChEBI + + + + + + + + + natural product fundamental parents + chebi_ontology + CHEBI:35507 + + natural product fundamental parent + + + + + natural product fundamental parents + IUPAC + + + + + @@ -12139,13 +14793,13 @@ For example, A and B may be gene products and binding of B by A positively regul - oxoacids of carbon + carbon oxoacids ChEBI - carbon oxoacids + oxoacids of carbon ChEBI @@ -12199,6 +14853,33 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A drug used to cause dilation of the blood vessels. + chebi_ontology + vasodilator + vasodilator agents + CHEBI:35620 + + vasodilator agent + + + + + vasodilator + ChEBI + + + + + vasodilator agents + ChEBI + + + + @@ -12268,6 +14949,41 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + 0 + C16H21N + InChI=1S/C16H21N/c1-2-6-13-12(5-1)11-15-14-7-3-4-8-16(13,14)9-10-17-15/h1-2,5-6,14-15,17H,3-4,7-11H2/t14-,15+,16-/m0/s1 + INAXVFBXDYWQFN-XHSDSOJGSA-N + 227.34468 + 227.16740 + [H][C@@]12CCCC[C@@]11CCN[C@@H]2Cc2ccccc12 + Beilstein:1375527 + morphinan + chebi_ontology + CHEBI:35649 + + morphinan + + + + + Beilstein:1375527 + Beilstein + + + + + morphinan + IUPAC + + + + + @@ -12938,6 +15654,25 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + chebi_ontology + organic hydrides + CHEBI:37175 + + organic hydride + + + + + organic hydrides + ChEBI + + + + @@ -13226,6 +15961,25 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + chebi_ontology + organic heteropentacyclic compounds + CHEBI:38164 + + organic heteropentacyclic compound + + + + + organic heteropentacyclic compounds + ChEBI + + + + @@ -13248,6 +16002,22 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + Any of a class of heterocyclic amines having a saturated five-membered ring. + CHEBI:26922 + CHEBI:38191 + chebi_ontology + CHEBI:38260 + + pyrrolidines + + + + @@ -13268,6 +16038,114 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. + chebi_ontology + cholinergic agent + cholinergic drugs + cholinomimetic + CHEBI:38323 + + cholinergic drug + + + + + cholinergic agent + ChEBI + + + + + cholinergic drugs + ChEBI + + + + + cholinomimetic + ChEBI + + + + + + + + + Any drug that binds to and activates cholinergic receptors. + chebi_ontology + acetylcholine agonist + acetylcholine agonists + acetylcholine receptor agonist + cholinergic agonists + cholinomimetic + cholinomimetics + CHEBI:38324 + + cholinergic agonist + + + + + acetylcholine agonist + ChEBI + + + + + acetylcholine agonists + ChEBI + + + + + acetylcholine receptor agonist + IUPHAR + + + + + cholinergic agonists + ChEBI + + + + + cholinomimetic + ChEBI + + + + + cholinomimetics + ChEBI + + + + + + + + + chebi_ontology + isoquinoline alkaloid fundamental parents + CHEBI:38515 + + isoquinoline alkaloid fundamental parent + + + + + isoquinoline alkaloid fundamental parents + ChEBI + + + + @@ -13547,6 +16425,96 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has R-configuration. + 0 + C10H14N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m1/s1 + SNICXCGAKADSCV-SNVBAGLBSA-N + 162.23160 + 162.11570 + CN1CCC[C@@H]1c1cccnc1 + Beilstein:4666243 + Beilstein:82110 + CAS:25162-00-9 + KEGG:C16386 + 3-[(2R)-1-methylpyrrolidin-2-yl]pyridine + chebi_ontology + (+)-nicotine + (R)-3-(1-methyl-2-pyrrolidinyl)pyridine + d-nicotine + pseudonicotine + CHEBI:39162 + + (R)-nicotine + + + + + Beilstein:4666243 + ChemIDplus + + + + + Beilstein:82110 + Beilstein + + + + + CAS:25162-00-9 + ChemIDplus + + + + + 3-[(2R)-1-methylpyrrolidin-2-yl]pyridine + IUPAC + + + + + + (+)-nicotine + ChemIDplus + + + + + (R)-3-(1-methyl-2-pyrrolidinyl)pyridine + ChemIDplus + + + + + d-nicotine + ChemIDplus + + + + + pseudonicotine + ChemIDplus + + + + @@ -13650,6 +16618,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + chebi_ontology + N-alkylpyrrolidines + CHEBI:46775 + + N-alkylpyrrolidine + + + + + N-alkylpyrrolidines + ChEBI + + + + @@ -13748,6 +16736,69 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc. + chebi_ontology + Indikator + CHEBI:47867 + + indicator + + + + + Indikator + ChEBI + + + + + + + + + An agonist that selectively binds to and activates a nicotinic acetylcholine receptor. + CHEBI:82738 + Wikipedia:Nicotinic_acetylcholine_receptor + chebi_ontology + muscarinic agonists + nicotinic acetylcholine receptor agonists + nicotinic agonist + nicotinic agonists + CHEBI:47958 + + nicotinic acetylcholine receptor agonist + + + + + muscarinic agonists + ChEBI + + + + + nicotinic acetylcholine receptor agonists + ChEBI + + + + + nicotinic agonist + ChEBI + + + + + nicotinic agonists + ChEBI + + + + @@ -14100,6 +17151,33 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. + chebi_ontology + peripheral nervous system agent + peripheral nervous system drugs + CHEBI:49110 + + peripheral nervous system drug + + + + + peripheral nervous system agent + ChEBI + + + + + peripheral nervous system drugs + ChEBI + + + + @@ -14344,6 +17422,56 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + Biologically active substance whose activity affects or plays a role in the functioning of the immune system. + Wikipedia:Immunotherapy + chebi_ontology + Biomodulator + Immune factor + Immunologic factor + Immunological factor + immunomodulators + CHEBI:50846 + + immunomodulator + + + + + Biomodulator + ChEBI + + + + + Immune factor + ChEBI + + + + + Immunologic factor + ChEBI + + + + + Immunological factor + ChEBI + + + + + immunomodulators + ChEBI + + + + @@ -14386,6 +17514,41 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy. + Wikipedia:Allergen + chebi_ontology + alergeno + allergene + allergenic agent + CHEBI:50904 + + allergen + + + + + alergeno + ChEBI + + + + + allergene + ChEBI + + + + + allergenic agent + ChEBI + + + + @@ -14913,6 +18076,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A chemical substance that encourages a cell to commence cell division, triggering mitosis. + chebi_ontology + mitogens + CHEBI:52290 + + mitogen + + + + + mitogens + ChEBI + + + + @@ -14933,6 +18116,42 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + A compound that exhibits agonist activity at the mu-opioid receptor. + CHEBI:50136 + chebi_ontology + mu opioid agonist + mu-opioid agonists + mu-opioid receptor agonists + CHEBI:55322 + + mu-opioid receptor agonist + + + + + mu opioid agonist + ChEBI + + + + + mu-opioid agonists + ChEBI + + + + + mu-opioid receptor agonists + ChEBI + + + + @@ -15001,6 +18220,75 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + The conjugate acid of morphine arising from protonation of the tertiary amino group; major species at pH 7.3. + +1 + C17H20NO3 + InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/p+1/t10-,11+,13-,16-,17-/m0/s1 + BQJCRHHNABKAKU-KBQPJGBKSA-O + 286.34560 + 286.14377 + [H][C@]12C=C[C@H](O)[C@@H]3Oc4c(O)ccc5C[C@H]1[NH+](C)CC[C@@]23c45 + 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-17-ium-3,6alpha-diol + chebi_ontology + morphine + morphine cation + CHEBI:58097 + + morphine(1+) + + + + + 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-17-ium-3,6alpha-diol + IUPAC + + + + + + morphine + UniProt + + + + + morphine cation + ChEBI + + + + + + + + + A substance used as an indicator of a biological state. + chebi_ontology + biological marker + CHEBI:59163 + + biomarker + + + + + biological marker + ChEBI + + + + @@ -15036,6 +18324,115 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + + + The conjugate acid of (S)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3. + +1 + C10H15N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m0/s1 + SNICXCGAKADSCV-JTQLQIEISA-O + 163.23900 + 163.12297 + C[NH+]1CCC[C@H]1c1cccnc1 + Gmelin:329042 + MetaCyc:NICOTINE + (2S)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + chebi_ontology + (S)-nicotine + (S)-nicotinium cation + CHEBI:59806 + + (S)-nicotinium(1+) + + + + + Gmelin:329042 + Gmelin + + + + + (2S)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + IUPAC + + + + + + (S)-nicotine + UniProt + + + + + (S)-nicotinium cation + ChEBI + + + + + + + + + A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types. + chebi_ontology + Chemische Substanz + CHEBI:59999 + + chemical substance + + + + + Chemische Substanz + ChEBI + + + + + + + + + A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind. + chebi_ontology + Mischung + CHEBI:60004 + + mixture + + + + + Mischung + ChEBI + + + + @@ -15125,6 +18522,95 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter. + chebi_ontology + opioid agents + CHEBI:60598 + + opioid agent + + + + + opioid agents + ChEBI + + + + + + + + + Any agent that acts on a mu-opioid receptor. + chebi_ontology + mu-opioid agents + CHEBI:60599 + + mu-opioid agent + + + + + mu-opioid agents + ChEBI + + + + + + + + + + An agent that selectively binds to and activates an opioid receptor. + chebi_ontology + opiate agonist + opiate agonists + opioid agonist + opioid agonists + opioid receptor agonists + CHEBI:60606 + + opioid receptor agonist + + + + + opiate agonist + ChEBI + + + + + opiate agonists + ChEBI + + + + + opioid agonist + ChEBI + + + + + opioid agonists + ChEBI + + + + + opioid receptor agonists + ChEBI + + + + @@ -15222,6 +18708,40 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A racemate is an equimolar mixture of a pair of enantiomers. + chebi_ontology + melange racemique + racemates + racemic mixture + CHEBI:60911 + + racemate + + + + + melange racemique + ChEBI + + + + + racemates + ChEBI + + + + + racemic mixture + ChEBI + + + + @@ -16233,6 +19753,61 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + The conjugate acid of (R)-nicotine arising from selective protonation of the tertiary amino group; major species at pH 7.3. + +1 + C10H15N2 + InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m1/s1 + SNICXCGAKADSCV-SNVBAGLBSA-O + 163.23900 + 163.12297 + C[NH+]1CCC[C@@H]1c1cccnc1 + MetaCyc:R-NICOTINE + (2R)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + chebi_ontology + (R)-nicotine + CHEBI:79008 + + (R)-nicotinium(1+) + + + + + MetaCyc:R-NICOTINE + SUBMITTER + + + + + (2R)-1-methyl-2-(pyridin-3-yl)pyrrolidinium + IUPAC + + + + + + (R)-nicotine + UniProt + + + + @@ -16273,6 +19848,27 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + Any drug which causes the onset of an allergic reaction. + chebi_ontology + allergenic drug + CHEBI:88188 + + drug allergen + + + + + allergenic drug + ChEBI + + + + @@ -16371,7 +19967,7 @@ For example, A and B may be gene products and binding of B by A positively regul A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. - GOC:mtg_cardio + GOC:mtg_cardio @@ -16392,7 +19988,7 @@ For example, A and B may be gene products and binding of B by A positively regul A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). GOC:cjm - GOC:mtg_cardio + GOC:mtg_cardio GOC:mtg_kidney_jan10 @@ -17710,7 +21306,7 @@ For example, A and B may be gene products and binding of B by A positively regul A organ system process carried out by any of the organs or tissues of neurological system. GOC:ai - GOC:mtg_cardio + GOC:mtg_cardio @@ -19016,7 +22612,7 @@ For example, A and B may be gene products and binding of B by A positively regul Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. - GOC:BHF + GOC:BHF GOC:dph GOC:tb @@ -19331,7 +22927,7 @@ For example, A and B may be gene products and binding of B by A positively regul Any process that modulates the frequency, rate or extent of defecation. - GOC:obol + GOC:obol @@ -19369,13 +22965,13 @@ For example, A and B may be gene products and binding of B by A positively regul Any process that modulates the frequency, rate or extent of grooming behavior. - GOC:BHF + GOC:BHF regulation of grooming behaviour - GOC:obol + GOC:obol @@ -22469,6 +26065,34 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + "Behavior related to the intake of morphine." [NBOC:GVG] + George Gkoutos + morphine consumption + + + + @@ -22497,6 +26121,91 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + "Behavior as a result of sensitivity to morphine" [NBOC:GVG] + George Gkoutos + behavioral response to morphine + + + + + + + + + + + + + + + + + + + + + + + + + + "Behavior as a result of sensitivity to nicotine intake." [NBOC:GVG] + George Gkoutos + GO:0035095 + behavioral response to nicotine + + + + + + + + + + + + + + + + + + + + + + + + + + "Behavior related to the intake of nicotine." [NBOC:GVG] + George Gkoutos + nicotine consumption + + + + @@ -22566,6 +26275,52 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + "Any process that modulates the frequency, rate or extent of nicotine consumption, the specific actions or reactions of an organism in response to external or internal stimuli." [NBOC:GVG] + George Gkoutos + regulation of nicotine consumption + + + + + + + + + + + + + + + + + + + + + "Any process that modulates the frequency, rate or extent of morphine consumption, the specific actions or reactions of an organism in response to external or internal stimuli." [NBOC:GVG] + George Gkoutos + regulation of morphine consumption + + + + @@ -27822,7 +31577,7 @@ For example, A and B may be gene products and binding of B by A positively regul the term 'urogenital sinus' may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal - MP + MP @@ -29834,7 +33589,7 @@ For example, A and B may be gene products and binding of B by A positively regul In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong] NCBITaxon:8292 - ISBN:0073040584 + ISBN:0073040584 @@ -31051,7 +34806,7 @@ For example, A and B may be gene products and binding of B by A positively regul Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA] - FMA:FMA + FMA:FMA @@ -31117,7 +34872,7 @@ For example, A and B may be gene products and binding of B by A positively regul Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] - FMA:FMA + FMA:FMA @@ -35706,7 +39461,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ISBN:0073040584 + ISBN:0073040584 @@ -37227,7 +40982,7 @@ For example, A and B may be gene products and binding of B by A positively regul A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. BSPO:0000063 - UBERONREF:0000006 + UBERONREF:0000006 @@ -38748,7 +42503,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -39892,7 +43647,7 @@ For example, A and B may be gene products and binding of B by A positively regul - MP + MP @@ -42912,7 +46667,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000453 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -46129,7 +49884,7 @@ For example, A and B may be gene products and binding of B by A positively regul Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. - FMA:FMA + FMA:FMA ISBN:0471888893 @@ -48865,7 +52620,7 @@ For example, A and B may be gene products and binding of B by A positively regul Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. TAO:0001115 - UBERONREF:0000006 + UBERONREF:0000006 @@ -50725,7 +54480,7 @@ For example, A and B may be gene products and binding of B by A positively regul Anatomical system that consists of the muscular and skeletal systems. VSAO:0000031 - VSAO:curator + VSAO:curator @@ -50803,7 +54558,7 @@ For example, A and B may be gene products and binding of B by A positively regul Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA] - FMA:FMA + FMA:FMA @@ -52509,7 +56264,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ISBN:0073040584 + ISBN:0073040584 @@ -52701,7 +56456,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000150 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -55156,7 +58911,7 @@ For example, A and B may be gene products and binding of B by A positively regul osteogenic tissue - VSAO:curator + VSAO:curator @@ -55629,14 +59384,14 @@ For example, A and B may be gene products and binding of B by A positively regul - ISBN:0073040584 + ISBN:0073040584 The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. - ISBN:0073040584 + ISBN:0073040584 NCIT:C33820 @@ -63307,7 +67062,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -63560,7 +67315,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -63619,7 +67374,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -77856,7 +81611,7 @@ For example, A and B may be gene products and binding of B by A positively regul dermal element - VSAO:curator + VSAO:curator @@ -78366,7 +82121,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -78466,7 +82221,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -79432,7 +83187,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -82596,7 +86351,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true @@ -87891,7 +91646,7 @@ For example, A and B may be gene products and binding of B by A positively regul - true + true MA @@ -89867,7 +93622,7 @@ For example, A and B may be gene products and binding of B by A positively regul An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. - ZFIN:ZDB-PUB-961014-576 + ZFIN:ZDB-PUB-961014-576 @@ -90329,7 +94084,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000510 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -90836,14 +94591,14 @@ For example, A and B may be gene products and binding of B by A positively regul Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. VSAO:0005000 - VSAO:NI + VSAO:NI cheiropterygium VSAO:0005000 - VSAO:NI + VSAO:NI @@ -91261,6 +95016,12 @@ For example, A and B may be gene products and binding of B by A positively regul presumptive neural plate + + + + A presumptive structure that has the potential to develop into a neural plate. + OBOL:automatic + @@ -91282,12 +95043,6 @@ For example, A and B may be gene products and binding of B by A positively regul prospective vegetal ectoderm ZFA:0000063 - - - - A presumptive structure that has the potential to develop into a neural plate. - OBOL:automatic - @@ -91796,7 +95551,7 @@ For example, A and B may be gene products and binding of B by A positively regul enveloping layer - ZFIN:ZDB-PUB-961014-576 + ZFIN:ZDB-PUB-961014-576 @@ -97116,7 +100871,7 @@ For example, A and B may be gene products and binding of B by A positively regul - MP + MP @@ -97206,7 +100961,7 @@ For example, A and B may be gene products and binding of B by A positively regul - MP + MP @@ -99036,7 +102791,7 @@ For example, A and B may be gene products and binding of B by A positively regul replacement skeleton - VSAO:curator + VSAO:curator @@ -99114,26 +102869,26 @@ For example, A and B may be gene products and binding of B by A positively regul exoskeleton - VSAO:curator + VSAO:curator dermal skeletal system - VSAO:curator + VSAO:curator dermoskeleton - VSAO:curator + VSAO:curator desmoskeleton - VSAO:curator + VSAO:curator @@ -99970,7 +103725,7 @@ For example, A and B may be gene products and binding of B by A positively regul Skeletal subdivision that is a segment of the limb skeleton. VSAO:0005018 - VSAO:NI + VSAO:NI @@ -101690,7 +105445,7 @@ For example, A and B may be gene products and binding of B by A positively regul The part of the trunk that is in the dorsum[cjm]. - UBERONREF:0000006 + UBERONREF:0000006 @@ -102819,7 +106574,7 @@ For example, A and B may be gene products and binding of B by A positively regul - MP + MP diff --git a/src/ontology/imports/omo_import.owl b/src/ontology/imports/omo_import.owl index 863ad3d7..557d6c37 100644 --- a/src/ontology/imports/omo_import.owl +++ b/src/ontology/imports/omo_import.owl @@ -10,9 +10,9 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2022-01-19 + + + 2022-08-03 @@ -97,6 +97,18 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + + + + + + + @@ -129,6 +141,42 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + An alternative label for a class or property which has a more general meaning than the preferred name/primary label. + + https://github.com/information-artifact-ontology/ontology-metadata/issues/18 + has broad synonym + https://github.com/information-artifact-ontology/ontology-metadata/issues/18 + + + + + + + + An alternative label for a class or property which has the exact same meaning than the preferred name/primary label. + + https://github.com/information-artifact-ontology/ontology-metadata/issues/20 + has exact synonym + https://github.com/information-artifact-ontology/ontology-metadata/issues/20 + + + + + + + + An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct. + + https://github.com/information-artifact-ontology/ontology-metadata/issues/21 + has related synonym + https://github.com/information-artifact-ontology/ontology-metadata/issues/21 + + + + + + + + The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not. + This obsolesence reason should be used conservatively. Typical valid examples are: un-necessary grouping classes in disease ontologies, a phenotype term added on the assumption it was a disease. + + https://github.com/information-artifact-ontology/ontology-metadata/issues/77 + https://orcid.org/0000-0001-5208-3432 + out of scope + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -166,6 +199,14 @@ + + + + + + + + @@ -182,6 +223,14 @@ + + + + + + + + @@ -214,6 +263,14 @@ + + + + + + + + @@ -256,6 +313,12 @@ + + + + + + @@ -352,17 +415,9 @@ - - - - - - - - shorthand - + @@ -2313,13 +2368,13 @@ For example, A and B may be gene products and binding of B by A positively regul suffrutex (narrow) - FNA:99508f62-7116-4e2b-90c0-19ff55ebd967 + FNA:99508f62-7116-4e2b-90c0-19ff55ebd967 suffrutices (narrow) - FNA:ba1b1bd5-75bd-4195-b11c-3aba08da08c2 + FNA:ba1b1bd5-75bd-4195-b11c-3aba08da08c2 @@ -3179,7 +3234,7 @@ For example, A and B may be gene products and binding of B by A positively regul simple plant organ (related) - PATO:01503 + PATO:01503 @@ -3301,7 +3356,7 @@ For example, A and B may be gene products and binding of B by A positively regul Arabidopsis growth (related) - TAIR:0000205 + TAIR:0000205 @@ -4722,7 +4777,7 @@ For example, A and B may be gene products and binding of B by A positively regul A phyllome anlagen (PO:0025430) that will give rise to a vascular leaf primordium (PO:0000017) and is part of a peripheral zone (PO:0000225) of a shoot apical meristem (PO:0020148). - PMID:14732442 + PMID:14732442 POC:Laurel_Cooper diff --git a/src/ontology/imports/pr_import.owl b/src/ontology/imports/pr_import.owl index 831f6110..6223936c 100644 --- a/src/ontology/imports/pr_import.owl +++ b/src/ontology/imports/pr_import.owl @@ -1,6 +1,7 @@ - - 2022-01-19 + + 2022-08-03 @@ -42,15 +43,25 @@ - + - + + + + + + + + + + + - + - + @@ -132,17 +143,9 @@ - - - - - - - - shorthand - + @@ -368,7 +371,7 @@ protein residue - PRO:DAN + PRO:DAN @@ -692,14 +695,14 @@ An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB natural protein - PRO:DAN + PRO:DAN @@ -726,7 +729,7 @@ A protein with a core domain composition consisting of a signal peptide, a variable propeptide region and a Transforming growth factor beta like domain (Pfam:PF00019), which is a cystine-knot domain containing four conserved beta strands, S1-S4, which form two antiparallel beta sheets (SI-S2 and S3-S4) interconnected by three disulfide bridges in a knot-like topology. Cystines [II-V] and [III-VI] form a ring through which the remaining disulfide bond (Cys[I-IV]) penetrates. Insertion of different variable regions into this common motif has given rise to various subclasses of the growth factor cystine-knot domain. - PRO:CNA + PRO:CNA @@ -746,7 +749,7 @@ A protein with a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229). - PRO:CNA + PRO:CNA @@ -797,13 +800,13 @@ A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. PMID:11053079 - PRO:CNA + PRO:CNA TNF - PRO:DNx + PRO:DNx @@ -837,7 +840,7 @@ A protein with a core domain composition consisting of a propeptide region and an Interleukin-1 / 18 domain. PMID:8001745 - PRO:CNA + PRO:CNA @@ -867,7 +870,7 @@ fam:IL-17 - PRO:DAN + PRO:DAN @@ -891,14 +894,14 @@ An interleukin-1 that is a translation product of the human IL1A gene or a 1:1 ortholog thereof. Critical mediator of the immune and inflammatory responses. - PRO:CNA + PRO:CNA Wikipedia:Interleukin_1 IL1A - PRO:DNx + PRO:DNx @@ -928,13 +931,13 @@ An interleukin-1 that is a translation product of the human IL1B gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL1B - PRO:DNx + PRO:DNx @@ -963,13 +966,13 @@ A protein that is a translation product of the human IL7 gene or a 1:1 ortholog thereof. - PRO:JAN + PRO:JAN IL7 - PRO:DNx + PRO:DNx @@ -990,7 +993,7 @@ A protein with a core domain architecture consisting of an N-terminal Interleukin 10 (Pfam:PF00726) domain. - PRO:CNA + PRO:CNA @@ -1016,13 +1019,13 @@ A protein that is a translation product of the human IL13 gene or a 1:1 ortholog thereof. Interleukin-13 is a pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. It inhibits inflammatory cytokine production and synergises with IL-2 in regulating interferon-gamma synthesis. The sequences of IL-4 and IL-13 are distantly related. PANTHER:PTHR11322 - PRO:CNA + PRO:CNA IL13 - PRO:DNx + PRO:DNx @@ -1051,13 +1054,13 @@ A protein that is a translation product of the human IL15 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL15 - PRO:DNx + PRO:DNx @@ -1079,13 +1082,13 @@ A protein that is a translation product of the human IL16 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL16 - PRO:DNx + PRO:DNx @@ -1115,13 +1118,13 @@ A protein that is a translation product of the human IL18 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL18 - PRO:DNx + PRO:DNx @@ -1160,13 +1163,13 @@ A protein that is a translation product of the human IL2 gene or a 1:1 ortholog thereof. Interleukin-2 has a dual role in maintaining tolerance and contributing to immunity. PMID:18062768 - PRO:CNA + PRO:CNA IL2 - PRO:DNx + PRO:DNx @@ -1190,13 +1193,13 @@ A protein that is a translation product of the human IL21 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL21 - PRO:DNx + PRO:DNx @@ -1225,13 +1228,13 @@ A protein that is a translation product of the human IL3 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL3 - PRO:DNx + PRO:DNx @@ -1268,13 +1271,13 @@ A protein that is a translation product of the human IL4 gene or a 1:1 ortholog thereof. - PRO:JAN + PRO:JAN IL4 - PRO:DNx + PRO:DNx @@ -1304,13 +1307,13 @@ A protein that is a translation product of the human IL5 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA IL5 - PRO:DNx + PRO:DNx @@ -1343,13 +1346,13 @@ A protein that is a translation product of the human IL6 gene or a 1:1 ortholog thereof. - PRO:JAN + PRO:JAN IL6 - PRO:DNx + PRO:DNx @@ -1380,13 +1383,13 @@ A protein that is a translation product of the human IL9 gene or a 1:1 ortholog thereof. - PRO:JAN + PRO:JAN IL9 - PRO:DNx + PRO:DNx @@ -1412,13 +1415,13 @@ A class 2 cytokine, IL-10 type that is a translation product of the human IL10 gene or a 1:1 ortholog thereof. Active interleukin-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structurally, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulfide bonds. PANTHER:PTHR11585:SF1 - PRO:JAN + PRO:JAN IL10 - PRO:DNx + PRO:DNx @@ -1440,13 +1443,13 @@ A protein with core architecture consisting of a signal sequence,1-2 Ig-like domains (Pfam:PF07686 and Pfam:PF08205), a transmembrane region, and a cytoplasmic region containing one SPRY domain (Pfam:PF00622). - PRO:WCB + PRO:WCB fam:BTN - PRO:DAN + PRO:DAN @@ -1478,13 +1481,13 @@ A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx ADIPOQ - PRO:DNx + PRO:DNx @@ -1532,13 +1535,13 @@ A protein that is a translation product of the human AFP gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx AFP - PRO:DNx + PRO:DNx @@ -1568,13 +1571,13 @@ A serpin that is a translation product of the human AGT gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA AGT - PRO:DNx + PRO:DNx @@ -1605,13 +1608,13 @@ A protein that is a translation product of the human CSN1S1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CSN1S1 - PRO:DNx + PRO:DNx @@ -1658,13 +1661,13 @@ A protein that is a translation product of the human CSN2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CSN2 - PRO:DNx + PRO:DNx @@ -1694,13 +1697,13 @@ A protein that is a translation product of the human CSN3 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CSN3 - PRO:DNx + PRO:DNx @@ -1740,13 +1743,13 @@ A protein that is a translation product of the human EPO gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx EPO - PRO:DNx + PRO:DNx @@ -1770,13 +1773,13 @@ A protein that is a translation product of the human FN1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx FN1 - PRO:DNx + PRO:DNx @@ -1809,13 +1812,13 @@ A protein that is a translation product of the human GAD1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx GAD1 - PRO:DNx + PRO:DNx @@ -1849,19 +1852,19 @@ An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx insulin - PRO:DAN + PRO:DAN INS - PRO:DNx + PRO:DNx @@ -1889,25 +1892,25 @@ A protein that is a translation product of the human IGF1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx IGF-I - PRO:DNx + PRO:DNx MGF - PRO:DNx + PRO:DNx IGF1 - PRO:DNx + PRO:DNx @@ -1943,13 +1946,13 @@ A protein that is a translation product of the human LALBA gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LALBA - PRO:DNx + PRO:DNx @@ -1980,13 +1983,13 @@ A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LEP - PRO:DNx + PRO:DNx @@ -2023,13 +2026,13 @@ A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LTF - PRO:DNx + PRO:DNx @@ -2077,13 +2080,13 @@ A protein that is a translation product of the human NPPA gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx NPPA - PRO:DNx + PRO:DNx @@ -2116,13 +2119,13 @@ A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx PRL - PRO:DNx + PRO:DNx @@ -2145,13 +2148,13 @@ A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx PTH - PRO:DNx + PRO:DNx @@ -2174,13 +2177,13 @@ An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof. - PRO:DAN + PRO:DAN REN - PRO:DNx + PRO:DNx @@ -2203,13 +2206,13 @@ A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx SST - PRO:DNx + PRO:DNx @@ -2241,13 +2244,13 @@ A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx TF - PRO:DNx + PRO:DNx @@ -2256,6 +2259,12 @@ PRO1400 + + + + Trf + + @@ -2276,13 +2285,13 @@ A protein that is a translation product of the human VWF gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx VWF - PRO:DNx + PRO:DNx @@ -2310,13 +2319,13 @@ A protein that is a translation product of the mouse Wap gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Wap - PRO:DNx + PRO:DNx @@ -2344,20 +2353,20 @@ An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. - PRO:DAN + PRO:DAN PRO:JSG peptide - PRO:DAN + PRO:DAN polypeptide - PRO:DAN + PRO:DAN @@ -2395,26 +2404,26 @@ A protein that is produced as the result of proteolytic processing of a longer protein. - PRO:DAN + PRO:DAN ClvPrd - PRO:DAN + PRO:DAN peptide - PRO:DAN + PRO:DAN polypeptide - PRO:DAN + PRO:DAN @@ -2452,13 +2461,13 @@ A tumor necrosis factor that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx TNF/ClvPrd - PRO:DNx + PRO:DNx @@ -2497,13 +2506,13 @@ An interleukin-1 alpha that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx IL1A/ClvPrd - PRO:DNx + PRO:DNx @@ -2542,13 +2551,13 @@ An interleukin-1 beta that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx IL1B/ClvPrd - PRO:DNx + PRO:DNx @@ -2586,13 +2595,13 @@ An interleukin-7 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL7/SigPep- - PRO:DNx + PRO:DNx @@ -2631,13 +2640,13 @@ An interleukin-16 that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx IL16/ClvPrd - PRO:DNx + PRO:DNx @@ -2676,13 +2685,13 @@ An interleukin-18 that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx IL18/ClvPrd - PRO:DNx + PRO:DNx @@ -2720,13 +2729,13 @@ An interleukin-2 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL2/SigPep- - PRO:DNx + PRO:DNx @@ -2764,13 +2773,13 @@ An interleukin-3 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL3/SigPep- - PRO:DNx + PRO:DNx @@ -2808,13 +2817,13 @@ An interleukin-4 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL4/SigPep- - PRO:DNx + PRO:DNx @@ -2852,13 +2861,13 @@ An interleukin-5 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL5/SigPep- - PRO:DNx + PRO:DNx @@ -2896,13 +2905,13 @@ An interleukin-6 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL6/SigPep- - PRO:DNx + PRO:DNx @@ -2940,13 +2949,13 @@ An interleukin-9 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL9/SigPep- - PRO:DNx + PRO:DNx @@ -2984,13 +2993,13 @@ An interleukin-10 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL10/SigPep- - PRO:DNx + PRO:DNx @@ -3028,13 +3037,13 @@ An adiponectin that has had the signal peptide removed. - PRO:DNx + PRO:DNx ADIPOQ/SigPep- - PRO:DNx + PRO:DNx @@ -3072,13 +3081,13 @@ An alpha-fetoprotein that has had the signal peptide removed. - PRO:DNx + PRO:DNx AFP/SigPep- - PRO:DNx + PRO:DNx @@ -3117,13 +3126,13 @@ An angiotensinogen that has had the signal peptide removed. - PRO:DNx + PRO:DNx AGT/SigPep- - PRO:DNx + PRO:DNx @@ -3162,13 +3171,13 @@ An angiotensinogen, signal peptide removed form that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx AGT/ClvPrd - PRO:DAN + PRO:DAN @@ -3206,13 +3215,13 @@ An alpha-S1-casein that has had the signal peptide removed. - PRO:DNx + PRO:DNx CSN1S1/SigPep- - PRO:DNx + PRO:DNx @@ -3251,13 +3260,13 @@ An alpha-S1-casein that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx CSN1S1/ClvPrd - PRO:DNx + PRO:DNx @@ -3295,13 +3304,13 @@ A beta-casein that has had the signal peptide removed. - PRO:DNx + PRO:DNx CSN2/SigPep- - PRO:DNx + PRO:DNx @@ -3339,13 +3348,13 @@ A kappa-casein that has had the signal peptide removed. - PRO:DNx + PRO:DNx CSN3/SigPep- - PRO:DNx + PRO:DNx @@ -3383,13 +3392,13 @@ An erythropoietin that has had the signal peptide removed. - PRO:DNx + PRO:DNx EPO/SigPep- - PRO:DNx + PRO:DNx @@ -3428,13 +3437,13 @@ An erythropoietin that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx EPO/ClvPrd - PRO:DNx + PRO:DNx @@ -3472,13 +3481,13 @@ A fibronectin that has had the signal peptide removed. - PRO:DNx + PRO:DNx FN1/SigPep- - PRO:DNx + PRO:DNx @@ -3517,13 +3526,13 @@ A fibronectin that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx FN1/ClvPrd - PRO:DNx + PRO:DNx @@ -3562,20 +3571,20 @@ An insulin gene translation product that has had the signal peptide removed. Proinsulin consists of the insulin B and A chains linked by the C-peptide. Example: UniProtKB:P01308, 25-110. - PRO:DAN + PRO:DAN INS/SigPep- - PRO:DNx + PRO:DNx insulin, signal peptide removed form - PRO:DNx + PRO:DNx @@ -3613,13 +3622,13 @@ An insulin-like growth factor I that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx IGF1/ClvPrd - PRO:DNx + PRO:DNx @@ -3657,13 +3666,13 @@ An alpha-lactalbumin that has had the signal peptide removed. - PRO:DNx + PRO:DNx LALBA/SigPep- - PRO:DNx + PRO:DNx @@ -3701,13 +3710,13 @@ A lactotransferrin that has had the signal peptide removed. - PRO:DNx + PRO:DNx LTF/SigPep- - PRO:DNx + PRO:DNx @@ -3746,13 +3755,13 @@ A lactotransferrin that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx LTF/ClvPrd - PRO:DNx + PRO:DNx @@ -3790,13 +3799,13 @@ An atrial natriuretic factor that has had the signal peptide removed. - PRO:DNx + PRO:DNx NPPA/SigPep- - PRO:DNx + PRO:DNx @@ -3835,13 +3844,13 @@ An atrial natriuretic factor that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx NPPA/ClvPrd - PRO:DNx + PRO:DNx @@ -3879,13 +3888,13 @@ A prolactin that has had the signal peptide removed. - PRO:DNx + PRO:DNx PRL/SigPep- - PRO:DNx + PRO:DNx @@ -3923,13 +3932,13 @@ A parathyroid hormone that has had the signal peptide removed. - PRO:DNx + PRO:DNx PTH/SigPep- - PRO:DNx + PRO:DNx @@ -3968,13 +3977,13 @@ A parathyroid hormone that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx PTH/ClvPrd - PRO:DNx + PRO:DNx @@ -4012,13 +4021,13 @@ A somatostatin that has had the signal peptide removed. - PRO:DNx + PRO:DNx SST/SigPep- - PRO:DNx + PRO:DNx @@ -4057,13 +4066,13 @@ A somatostatin that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx SST/ClvPrd - PRO:DNx + PRO:DNx @@ -4101,13 +4110,13 @@ A serotransferrin that has had the signal peptide removed. - PRO:DNx + PRO:DNx TF/SigPep- - PRO:DNx + PRO:DNx @@ -4145,13 +4154,13 @@ A von Willebrand factor that has had the signal peptide removed. - PRO:DNx + PRO:DNx VWF/SigPep- - PRO:DNx + PRO:DNx @@ -4190,13 +4199,13 @@ A von Willebrand factor that has been processed by proteolytic cleavage. - PRO:DNx + PRO:DNx VWF/ClvPrd - PRO:DNx + PRO:DNx @@ -4222,7 +4231,7 @@ A part of a protein that is removed during the protein maturation process. - PRO:DAN + PRO:DAN @@ -4249,13 +4258,13 @@ A protein that is a translation product of the Escherichia coli K-12 phoA gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx phoA - PRO:DNx + PRO:DNx @@ -4293,13 +4302,13 @@ An alkaline phosphatase that has had the signal peptide removed. - PRO:DNx + PRO:DNx phoA/SigPep- - PRO:DNx + PRO:DNx @@ -4321,19 +4330,19 @@ A protein that is a translation product of the human SAA2 gene or a 1:1 ortholog thereof. - PRO:DAN + PRO:DAN SAA - PRO:DNx + PRO:DNx SAA2 - PRO:DNx + PRO:DNx @@ -4371,13 +4380,13 @@ A primate-type serum amyloid A-2 protein that has had the signal peptide removed. - PRO:DAN + PRO:DAN SAA2/SigPep- - PRO:DNx + PRO:DNx @@ -4400,7 +4409,7 @@ A protein that is primarily known as an irreversible serine protease inhibitor active against S1, S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi. Serpin contains a copy of the Serpin (Pfam:PF00079) domain. InterPro:IPR000215 - PRO:CNA + PRO:CNA @@ -4420,13 +4429,13 @@ A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide. - PRO:DAN + PRO:DAN fam:GH1 - PRO:DNx + PRO:DNx @@ -4455,13 +4464,13 @@ An angiotensinogen proteolytic cleavage product that is formed via the action of renin on angiotensinogen, signal peptide removed form. PMID:18793332 - PRO:DAN + PRO:DAN ang I - PRO:DAN + PRO:DAN @@ -4492,13 +4501,13 @@ An angiotensinogen proteolytic cleavage product that is formed via the action of angiotensin converting enzyme on angiotensin I. PMID:18793332 - PRO:DAN + PRO:DAN ang II - PRO:DAN + PRO:DAN @@ -4519,13 +4528,13 @@ A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide. - PRO:DAN + PRO:DAN fam:INS - PRO:DAN + PRO:DAN @@ -4546,13 +4555,13 @@ A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. - PRO:DAN + PRO:DAN fam:angiotensinogenase - PRO:DAN + PRO:DAN diff --git a/src/ontology/imports/ro_import.owl b/src/ontology/imports/ro_import.owl index be228a9f..817fc752 100644 --- a/src/ontology/imports/ro_import.owl +++ b/src/ontology/imports/ro_import.owl @@ -16,9 +16,9 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - - 2022-01-19 + + + 2022-08-03 @@ -232,6 +232,12 @@ + + + + + + @@ -244,6 +250,12 @@ + + + + + + @@ -320,14 +332,6 @@ - - - - shorthand - - - - @@ -885,6 +889,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. + @@ -2129,21 +2134,73 @@ For example, A and B may be gene products and binding of B by A positively regul - + - + A diagnostic testing device utilizes a specimen. - X utilizes Y means X and Y are material entities, and X is capable of some process P that has input Y. - Asiyah Lin - Bill Duncan (https://orcid.org/0000-0001-9625-1899) + X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. + https://orcid.org/0000-0001-9625-1899 + https://orcid.org/0000-0003-2620-0345 A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08 - utilizes + 2021-11-08T12:00:00Z + utilizes + device utilizes material + + + + + + + + + + + + + + + A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. + + regulates characteristic + + + + + + + + + + + + + A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. + + positively regulates characteristic + + + + + + + + + + + + + + + + + A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. + + negatively regulates characteristic @@ -2356,6 +2413,14 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + @@ -2705,13 +2770,13 @@ For example, A and B may be gene products and binding of B by A positively regul - + - + - + @@ -3799,6 +3864,50 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/src/ontology/imports/so_import.owl b/src/ontology/imports/so_import.owl index e5bc1621..647082eb 100644 --- a/src/ontology/imports/so_import.owl +++ b/src/ontology/imports/so_import.owl @@ -11,9 +11,9 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2022-01-19 + 2022-08-03 @@ -59,12 +59,6 @@ - - - - - - @@ -77,12 +71,6 @@ - - - - - - @@ -149,12 +137,6 @@ - - - - - - @@ -482,7 +464,7 @@ An attribute describing a sequence consisting of nucleobases bound to repeating units. The forms found in nature are deoxyribonucleic acid (DNA), where the repeating units are 2-deoxy-D-ribose rings connected to a phosphate backbone, and ribonucleic acid (RNA), where the repeating units are D-ribose rings connected to a phosphate backbone. - CHEBI:33696 + CHEBI:33696 RSC:cb diff --git a/src/ontology/imports/uberon_import.owl b/src/ontology/imports/uberon_import.owl index 64c5109e..8aa4bbc5 100644 --- a/src/ontology/imports/uberon_import.owl +++ b/src/ontology/imports/uberon_import.owl @@ -10,9 +10,10 @@ xmlns:core="http://purl.obolibrary.org/obo/uberon/core#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" + xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + @@ -41,7 +42,7 @@ - + @@ -73,7 +74,7 @@ https://docs.google.com/document/d/1cPWBqrl_Qy7XHEWFqtR_PgQX61yRkgGuLaiDpnEXxkE/edit https://docs.google.com/document/d/1r9kNPpFYGdu0SpJDLyFAVQczBlG0wAZCBMd18gG3Ot8/edit# https://docs.google.com/spreadsheet/ccc?key=0Aj8NJdyb-leqdDM0R3hTVTRHRExDVjRCSkZEbDc5N1E#gid=0 - 2022-01-19 + 2022-08-03 @@ -110,6 +111,7 @@ + definition definition @@ -361,6 +363,134 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -441,6 +571,14 @@ + + + + + + + + @@ -521,10 +659,16 @@ - + + + + + + + - - http://purl.org/dc/elements/1.1/contributor + + http://purl.org/dc/terms/contributor uberon dc-contributor true @@ -534,21 +678,21 @@ - + - + - + - + - + - + @@ -836,9 +980,7 @@ - - shorthand - + @@ -930,18 +1072,27 @@ is part of + is part of my brain is part of my body (continuant parthood, two material entities) + my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) + my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) + this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. + Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) +A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. + Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) + A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. part_of + part_of @@ -954,6 +1105,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An external protein quality + spatial uberon part_of @@ -986,9 +1138,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y Chris Mungall + Chris Mungall David Osumi-Sutherland + David Osumi-Sutherland Melissa Haendel Terry Meehan + Terry Meehan RO:0002202 uberon develops_from @@ -1043,7 +1198,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An direct_transformation_of - https://orcid.org/0000-0002-6601-2165 + @@ -1095,6 +1250,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Lower, narrow portion of the uterus where it joins with the top end of the vagina. + The narrow caudal end of the uterus that opens into the vagina. [TFD][VHOG] The evolution of mammals is associated with radical changes in their reproductive biology, particularly the structure and function of the female reproductive organs. These changes include the evolution of the uterus, cervix, vagina, placenta and specialized cell types associated with each of those structures.[well established][VHOG] cervical @@ -1128,6 +1284,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cervix of uterus UBERON:0000002 + uterine cervix @@ -1494,6 +1651,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The clusters of hormone-producing cells that are scattered throughout the pancreas. + Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO] Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG] A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986) @@ -1523,6 +1681,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An islets of Langerhans UBERON:0000006 + islet of Langerhans @@ -1629,7 +1788,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Pituitary_gland XAO:0000017 ZFA:0000118 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=399 + neuronames:399 glandula pituitaria pituitary pituitary body @@ -1655,7 +1814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - BGEE:ANN + https://orcid.org/0000-0003-3308-6245 @@ -1715,7 +1874,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=399 + neuronames:399 BIRNLEX:1353 @@ -1842,7 +2001,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. - + Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) @@ -1875,13 +2034,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Peripheral_nervous_system XAO:0000178 ZFA:0000142 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3232 + neuronames:3232 pars peripherica systema nervosum periphericum uberon UBERON:0000010 + @@ -1900,14 +2060,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. GO:0007422 - - - - - ZFA - https://github.com/obophenotype/uberon/issues/378 - pending - @@ -2037,14 +2189,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An parasympathetic nervous system http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png - - - - pars parasympathica divisionis autonomici systematis nervosi - FMA:9907 - FMA:TA - - @@ -2115,6 +2259,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1305770 BIRNLEX:2517 + + + + pars parasympathica divisionis autonomici systematis nervosi + FMA:9907 + FMA:TA + + @@ -2409,7 +2561,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -2451,6 +2603,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. create a separate class for distributed pancreas, eg cyclostomes? + The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG] The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] @@ -2475,6 +2628,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An islets of Langerhans part of pancreas UBERON:0000016 + @@ -2570,6 +2724,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO] The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] @@ -2580,6 +2735,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100093 FMA:16017 MA:0002415 + MESH:D046790 NCIT:C32546 SCTID:248202004 TAO:0001249 @@ -2594,6 +2750,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An exocrine component of pancreas exocrine part of pancreas UBERON:0000017 + @@ -2954,6 +3111,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the epidermal growths that form the distinctive outer covering, or plumage, on birds. Feathers are formed in tiny follicles in the epidermis, or outer skin layer, that produce keratin proteins. + Among the characteristics that distinguish the extant Aves from other living groups. Feathers have also been noticed in those Theropoda which have been termed feathered dinosaurs. Although feathers cover most parts of the body of birds, they arise only from certain well-defined tracts on the skin. They aid in flight, thermal insulation, waterproofing and coloration that helps in communication and protection The beta-keratins in feathers, beaks and claws - and the claws, scales and shells of reptiles - are composed of protein strands hydrogen-bonded into beta-pleated sheets, which are then further twisted and crosslinked by disulfide bridges into structures even tougher than the alpha-keratins of mammalian hair, horns and hoof. BTO:0000447 @@ -3229,8 +3387,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. - - + Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG] BTO:0000784 CALOHA:TS-0579 @@ -3257,6 +3414,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nodus lymphaticus UBERON:0000029 + @@ -3270,19 +3428,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. BTO:0000784 - - - - - DOI:10.1177/0192623311409597 - ZFA:0005318 - - - - - - Wikipedia - @@ -3339,7 +3484,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000030 lamina propria - GI:Organization.svg + https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg @@ -3492,6 +3637,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An ovarian follicle that has one layer of granulosa cells. + BTO:0000410 EMAPA:35631 FMA:18634 @@ -3506,6 +3652,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An primary egg follicle primary follicle UBERON:0000035 + primary ovarian follicle @@ -3569,6 +3716,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A maturing ovarian follicle that has two more more layers of granulosa cells, up to the onset of antrum formation. consider adopting distinction in MA + EMAPA:35632 FMA:18637 MA:0002908 @@ -3583,6 +3731,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An secondary egg follicle secondary follicle UBERON:0000036 + secondary ovarian follicle @@ -3667,7 +3816,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tertiary ovarian follicle - Primary:follicle-4.JPG + https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG @@ -4175,7 +4324,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:918 EMAPA:32846 EV:0100372 - FBbt:00005137 FMA:5884 MA:0002406 MAT:0000207 @@ -4315,6 +4463,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A C-shaped bundle of fibres (axons) in the brain, and carries signals from the hippocampus to the mammillary bodies and septal nuclei. It is typically divided into the columns (crus), body, commissure and the pre-commissural and post-commissural fornix (MM). + fornix BAMS:f BIRNLEX:705 @@ -4330,7 +4479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0152334 UMLS:C0458370 Wikipedia:fornix_of_brain - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=268 + neuronames:268 brain fornix cerebral fornix forebrain fornix @@ -4342,6 +4491,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fornix hippocampus hippocampus fornix UBERON:0000052 + fornix of brain @@ -4385,7 +4535,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=268 + neuronames:268 BIRNLEX:705 @@ -4584,9 +4734,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A tubular structure that contains, conveys body fluid, such as blood or lymph. + uberon UBERON:0000055 + vessel @@ -4619,6 +4771,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. + Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO] The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG] @@ -4651,12 +4804,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An metanephric duct UBERON:0000056 + ureter - Urinary:system.svg + https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg @@ -4774,7 +4928,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An urethra - Female:anatomy.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png @@ -4889,6 +5043,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. + Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] AAO:0010396 BTO:0000706 @@ -4899,7 +5054,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:7201 GAID:306 MA:0000333 - MESH:A03.492.411.495 + MESH:D007420 MIAA:0000046 NCIT:C12379 OpenCyc:Mx4rvVkF5pwpEbGdrcN5Y29ycA @@ -4913,6 +5068,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An intestinum crassum UBERON:0000059 + @@ -5241,6 +5397,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + EHDAA2:0001606 EHDAA:1568 EHDAA:2219 @@ -5251,6 +5408,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000393 uberon UBERON:0000065 + respiratory tract @@ -5356,7 +5514,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. - Melissa Haendel + 2009-06-18T09:00:04Z BIRNLEX:1157 NCIT:C13040 @@ -5409,7 +5567,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO]. ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule? - Melissa Haendel + 2009-06-18T09:26:37Z glomerulus BTO:0000530 @@ -5440,8 +5598,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal glomerulus - Renal:corpuscle.svg http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg + https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg @@ -6316,7 +6474,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2:0000005 FMA:292334 GAID:1295 - MESH:A16.254.270.550 + MESH:D009028 NCIT:C34212 SCTID:361474003 UMLS:C0026573 @@ -6377,6 +6535,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. + Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG] zona pellucida - vitelline membrane BTO:0003135 @@ -6403,6 +6562,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An zona radiata zona striata UBERON:0000086 + zona pellucida @@ -6504,7 +6664,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An inner cell mass - Blastocyst:English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg @@ -6588,6 +6748,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP] trophoblastic The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta @@ -6596,7 +6757,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100120 FMA:83029 GAID:1152 - MESH:A11.936 + MESH:D014327 NCIT:C93292 SCTID:362839005 UMLS:C0041178 @@ -6608,10 +6769,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An trophoderm UBERON:0000088 + Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] trophoblast - Blastocyst:English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg @@ -6999,7 +7161,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A depression or fissure in the surface of an organ. - cjm + 2009-04-09T06:23:22Z Wikipedia:Sulcus_(anatomy) uberon @@ -7022,7 +7184,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. - cjm + 2009-07-30T05:19:13Z membrane FMA:7145 @@ -7054,7 +7216,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]. ZFA treats this as a subtype of NC. - cjm + 2009-07-30T07:57:38Z TAO:0002173 Wikipedia:Cardiac_neural_crest @@ -7112,6 +7274,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A lung lobe is one of the rounded projections that compose the lung[GO]. + EMAPA:36281 FMA:7311 MA:0003098 @@ -7125,6 +7288,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pulmonary lobe uberon UBERON:0000101 + lobe of lung @@ -7258,6 +7422,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBdv:00007012 FMA:24120 HsapDv:0000000 + MESH:D008018 MmusDv:0000000 OlatDv:0000010 PdumDv:0000090 @@ -7302,6 +7467,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. + it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces EMAPA:35521 FMA:27533 @@ -7315,6 +7481,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pulmonary connective tissue pulmonary interstitial tissue UBERON:0000114 + lung connective tissue @@ -7489,7 +7656,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class) - GO + GO @@ -7675,6 +7842,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cell layer consisting of lining cells that separates the central nervous system and the bloodstream. The BBB may consist of endothelial cells or glial cells. An endothelial barrier may have arisen independently several times during evolution. In bichir and lungfish the barrier is formed by brain endothelial cells, while in sturgeon it is formed by a complex perivascular glial sheath, but with no detectable tight junctions. + MESH:D001812 NCIT:C13194 UMLS:C0005854 Wikipedia:Blood-brain_barrier @@ -7928,6 +8096,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100267 FMA:54572 MA:0001014 + MESH:D065828 NCIT:C12898 SCTID:280166009 UMLS:C0228740 @@ -8075,6 +8244,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A layer of the ovarian follicle that consists of theca cells. + The theca folliculi are responsible for the production of testosterone from androstenedione in females, and indirectly the production of estrogens by supplying the neighboring granulosa cells with androstenedione that can then be used as a substrate for aromatase. [Wikipedia:Theca_of_follicle] BTO:0002853 EFO:0003629 @@ -8096,6 +8266,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thecal cell layers UBERON:0000155 + theca cell layer @@ -8154,6 +8325,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The theca externa is the outer layers of the theca folliculi. It contains abundant collagen and is mainly supportive. + UBERON:0005182 BTO:0002852 FMA:18657 @@ -8167,6 +8339,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An external coat of theca folliculi tunica externa thecae folliculi UBERON:0000156 + theca externa http://upload.wikimedia.org/wikipedia/commons/5/50/Mature_Graffian_follicle.jpg @@ -8230,6 +8403,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Theca interna cells express receptors for luteinizing hormone, which when activated will stimulate the production of androstenedione from cholesterol by the enzyme desmolase. Androstenedione ultimately gives the granulosa cells the precursor substrate for estrogen manufacturing. + UBERON:0005183 BTO:0002851 FMA:18658 @@ -8243,6 +8417,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An internal coat of capsule of Graafian follicle tunica interna thecae folliculi UBERON:0000157 + theca interna @@ -8340,11 +8515,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. requires alignment with EHDAA2 and complete developmental relationships + BTO:0001978 CALOHA:TS-2160 EMAPA:18256 FMA:15703 MA:0000330 + MESH:D001003 NCIT:C12375 SCTID:245438008 UMLS:C0227411 @@ -8362,6 +8539,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mesenteron pars analis recti UBERON:0000159 + anal canal @@ -8440,7 +8618,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:295 MA:0000328 MA:0001524 - MESH:A03.492.411 + MESH:D007422 MIAA:0000043 NCIT:C12736 SCTID:256876008 @@ -9240,6 +9418,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The pair of anatomical structures comprised of a left lung and right lung. + FMA:68877 OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA lungs @@ -9248,6 +9427,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An set of lungs uberon UBERON:0000170 + pair of lungs @@ -9461,6 +9641,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. + A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] @@ -9494,6 +9675,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An whole blood UBERON:0000178 + @@ -9581,7 +9763,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. - cjm + 2009-04-08T04:38:19Z CARO:0000081 uberon @@ -9675,7 +9857,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279165009 UMLS:C0458308 Wikipedia:Gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1211 + neuronames:1211 cerebral gyrus gyrus of neuraxis neuraxis gyrus @@ -9779,7 +9961,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume. In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus - cjm + 2009-04-18T12:03:09Z UBERON:0007333 BTO:0003399 @@ -9791,7 +9973,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Avian_pallium Wikipedia:Pallium_(neuroanatomy) ZFA:0000505 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3240 + neuronames:3240 area dorsalis telencephali dorsal part of telencephalon dorsal telencephalic area @@ -9871,7 +10053,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Ventral part (base region) of the telencephalon. BTO term refers specifically to the avian structure - cjm + 2009-04-18T12:12:27Z BTO:0003401 DMBA:15751 @@ -9968,8 +10150,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000209 tetrapod frontal bone - Frontal:bone.png http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png + https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png @@ -10130,13 +10312,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An actinopterygian frontal bone - TAO:0000514 + TAO:0000514 frontal bone - TAO:0000514 + TAO:0000514 @@ -10202,7 +10384,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ligament - Knee:diagram.svg + https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg @@ -10354,6 +10536,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected. + A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG] Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG] amniotic @@ -10365,7 +10548,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100122 FMA:80223 GAID:1298 - MESH:A16.254.403.277 + MESH:D000650 NCIT:C12365 SCTID:181457005 UMLS:C0002630 @@ -10374,6 +10557,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An amnios uberon UBERON:0000305 + amnion http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png @@ -10446,7 +10630,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BILA:0000059 BTO:0000128 GAID:1294 - MESH:A16.254.270.274 + MESH:D036703 OGEM:000006 OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg Wikipedia:Blastula @@ -10652,6 +10836,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mucosa that is part of a cecum [Automatically generated definition]. + BTO:0000213 FMA:14998 caecum mucosa @@ -10680,6 +10865,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An organ mucosa of intestinum crassum caecum uberon UBERON:0000314 + cecum mucosa @@ -10842,7 +11028,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + The space between the arachnoid and pia mater. @@ -10853,6 +11039,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MESH:D013346 SCTID:362311001 Wikipedia:Subarachnoid_space + subarachnoid space of CNS + subarachnoid space of central nervous system + subarachnoid space of neuraxis uberon cavitas subarachnoidea cavum subarachnoideale @@ -10873,6 +11062,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Subarachnoid_space https://sourceforge.net/p/obo/mammalian-phenotype-requests/1168/ + + + + subarachnoid space of neuraxis + FMA:322060 + @@ -10928,6 +11123,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. + UBERON:0003347 UBERON:0004981 BTO:0000271 @@ -10948,6 +11144,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0000317 + colonic mucosa @@ -11006,6 +11203,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mucosa that is part of a duodenum [Automatically generated definition]. + UBERON:0003348 BTO:0000367 CALOHA:TS-0213 @@ -11020,6 +11218,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon duodenum mucosa UBERON:0000320 + duodenal mucosa @@ -11092,7 +11291,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching. - BGEE:ANiknejad + https://orcid.org/0000-0003-3308-6245 @@ -11222,6 +11421,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mucosa that is part of a ileum [Automatically generated definition]. + BTO:0000619 CALOHA:TS-0470 EMAPA:35424 @@ -11239,6 +11439,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An organ mucosa of ileum uberon UBERON:0000331 + ileal mucosa @@ -11610,7 +11811,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000341 throat - Throat:Diagram.png + https://upload.wikimedia.org/wikipedia/commons/1/16/Throat_Diagram.png @@ -11766,6 +11967,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An entire myelin sheath + + + + medullary sheath + BTO:0000900 + @@ -11778,12 +11985,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0026973 ncithesaurus:Myelin_Sheath - - - - medullary sheath - BTO:0000900 - @@ -11798,6 +11999,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead. + Sensory medial ramus of the trigeminal nerve.[AAO] The profundus nerve is a distinct nerve only in fishes. (...) In mammals, the profundus nerve is the same as the most rostral (ophthalmic) branch of the trigeminal nerve.[well established][VHOG] AAO:0010648 @@ -11843,6 +12045,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An profundus nerve trigeminal nerve ophthalmic division UBERON:0000348 + Terminology notes. This nerve is known by a ridiculous number of names[http://palaeos.com/vertebrates/glossary/glossaryPo.html] ophthalmic nerve @@ -12065,13 +12268,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CALOHA:TS-1307 FMA:242000 GAID:615 - MESH:A08.186.211.577 + MESH:D008032 NCIT:C94541 OpenCyc:Mx4rwAeba5wpEbGdrcN5Y29ycA SCTID:361342009 UMLS:C0023715 Wikipedia:Limbic_system - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2055 + neuronames:2055 uberon visceral brain UBERON:0000349 @@ -12079,7 +12282,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An includes the hippocampus, amygdala, anterior thalamic nuclei, and limbic cortex, which support a variety of functions including emotion, behavior, long term memory, and olfaction [Wikipedia] limbic system - Brain:limbicsystem.jpg + https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg @@ -12183,7 +12386,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100394 FMA:83041 GAID:1153 - MESH:A16.254.085 + MESH:D001755 NCIT:C13739 SCTID:308837009 UMLS:C1281743 @@ -12194,7 +12397,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000358 blastocyst - Blastocyst:English.svg + https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg @@ -12331,6 +12534,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inner portion of the kidney consisting of the renal pyramids. + The renal medulla is split up into a number of sections, known as the renal pyramids. Blood enters into the kidney via the renal artery, which then splits up to form the arcuate arterioles. The arcuate arterioles each in turn branch into interlobular arterioles, which finally reach the glomeruli. At the glomerulus the blood reaches a highly disfavourable pressure gradient and a large exchange surface area, which forces the serum portion of the blood out of the vessel into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the Loop of Henle, and finally leaves the kidney by means of the collecting duct, leading to the renal ureter. The renal medulla contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood. The renal medulla is hypertonic to the filtrate in the nephron and aids in the reabsorption of water BTO:0001167 CALOHA:TS-1157 @@ -12355,9 +12559,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An medullary pyramids renal marrow UBERON:0000362 + + Note that 'renal medulla' is not synonymous with 'medullary region of kidney'. The former is composed of kidney pyramids only, while the latter covers kidney pyramids and renal columns, which are histologically different. renal medulla - Illu:kidney.jpg + https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg @@ -12481,7 +12687,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000365 urothelium - Harnblase:Urothel.png + https://upload.wikimedia.org/wikipedia/commons/9/91/Harnblase_Urothel.png @@ -12608,13 +12814,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100184 FMA:77616 GAID:667 - MESH:A08.186.211.730.885.105.487 + MESH:D003342 NCIT:C12448 SCTID:279318005 UMLS:C0010097 VHOG:0001175 Wikipedia:Corpus_striatum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2339 + neuronames:2339 uberon striate body striated body @@ -12677,6 +12883,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini. + AAO:0010688 AAO:0010703 BTO:0001375 @@ -12711,6 +12918,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervus mandibularis trigeminal nerve mandibular division UBERON:0000375 + mandibular nerve http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png @@ -12914,7 +13122,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000349 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -13005,6 +13213,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + Medial ramus (sensory) of the trigeminal nerve.[AAO] relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO] AAO:0010670 @@ -13037,6 +13246,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervus maxillaris trigeminal nerve maxillary division UBERON:0000377 + maxillary nerve http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png @@ -13473,6 +13683,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Bundles of smooth muscle fibers forming the muscular wall of the urinary bladder, which are arranged in a longitudinal and a circular layer and, on contraction, serve to expel urine[MP]. + muscularis propria BTO:0001453 EMAPA:28637 @@ -13493,9 +13704,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon musculus detrusor vesicae urinariae UBERON:0000381 + urinary bladder detrusor smooth muscle - Illu:bladder.jpg + https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg @@ -13586,12 +13798,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 @@ -13709,7 +13915,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:18289 FMA:55130 GAID:111 - MESH:A02.165.507.411 + MESH:D004825 NCIT:C12709 OpenCyc:Mx4rvVjxE5wpEbGdrcN5Y29ycA SCTID:245502004 @@ -13736,7 +13942,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A part of the pharynx that consists of a flap of elastic cartilage tissue plus a mucous membrane covering, attached to the entrance of the larynx. The epiglottis is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink[MP,modified]. - MGI:llw2 + MGI:llw2 MP:0010371 Wikipedia:Epiglottis http://orcid.org/0000-0002-6601-2165 @@ -13772,7 +13978,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362303006 UMLS:C0228126 Wikipedia:Leptomeninges - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2347 + neuronames:2347 leptomeninges uberon arachnoid mater and pia mater @@ -13941,7 +14147,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:368955007 VHOG:0001183 Wikipedia:Spiral_ganglion - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1405 + neuronames:1405 Corti's ganglion cochlear part of vestibulocochlear ganglion ganglion of Corti @@ -14169,6 +14375,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mucosa that is part of a jejunum [Automatically generated definition]. + BTO:0001742 CALOHA:TS-0495 EMAPA:27109 @@ -14186,6 +14393,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An organ mucosa of jejunum uberon UBERON:0000399 + jejunal mucosa @@ -14647,15 +14855,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - + - + - The part of the cerebral cortex responsible for processing visual information. + The part of the occipital lobe responsible for processing visual information. BAMS:VIS BTO:0001857 CALOHA:TS-1117 @@ -14665,40 +14872,23 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:242644 GAID:679 MBA:669 - MESH:A08.186.211.730.885.213.571.735 - Wikipedia:Visual_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1911 + MESH:D014793 + Wikipedia:Visual_cortex + neuronames:1911 uberon higher-order visual cortex visual areas UBERON:0000411 - The visual cortex is made up of Brodmann area 17 (the primary visual cortex), and Brodmann area 18 and Brodmann area 19, the extrastriate cortical areas. + The visual cortex is made up of Brodmann area 17 (the primary visual cortex), and Brodmann area 18 and Brodmann area 19, the extrastriate cortical areas, in humans. visual cortex http://upload.wikimedia.org/wikipedia/commons/7/70/Brodmann_areas_17_18_19.png - - - - - cjm - - - - - - - - - - - tgbugs - - The part of the cerebral cortex responsible for processing visual information. - Wikipedia:Visual_cortex + The part of the occipital lobe responsible for processing visual information. + Wikipedia:Visual_cortex @@ -14761,7 +14951,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts. Framed by the enlarged bulb matrix in anagen. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -14940,6 +15130,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion. + in mice, found only on footpads; in humans, entire body including soles and palms BTO:0002323 FMA:59154 @@ -14956,6 +15147,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An eccrine gland merocrine sweat gland UBERON:0000423 + eccrine sweat gland @@ -15018,6 +15210,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The prostate epithelium. TODO - check 2 FMA IDs + UBERON:0002452 BTO:0002397 CALOHA:TS-2065 @@ -15039,6 +15232,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An prostatic gland epithelium uberon UBERON:0000428 + prostate epithelium @@ -15181,6 +15375,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0002501 FMA:85273 Wikipedia:Trabecula + trabeculae uberon UBERON:0000440 @@ -15194,6 +15389,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO:0060343 Wikipedia:Trabecula + + + + trabeculae + + @@ -15208,12 +15409,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33040 SCTID:64626006 UMLS:C0229654 - lymphoid nodule nodular lymphoid tissue uberon folliculus lymphaticus lymphatic follicle lymphatic nodule + lymphoid nodule nodulus lymphaticus nodulus lymphoideus UBERON:0000444 @@ -15238,12 +15439,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0229654 ncithesaurus:Lymphoid_Follicle - - - - lymphoid nodule - FMA:55222 - @@ -15268,6 +15463,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lymphatic nodule BTO:0002684 + + + + lymphoid nodule + FMA:55222 + @@ -15301,9 +15502,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32837 FMA:61842 MA:0000924 - MESH:A08.186.211.577.750 UMLS:C0752060 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=255 + neuronames:255 area septalis septal area septum (NN) @@ -15333,7 +15533,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Se - PMID:23375746 + PMID:23375746 @@ -15351,7 +15551,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=255 + neuronames:255 BIRNLEX:963 @@ -16092,7 +16292,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An galen:Organism ncithesaurus:Whole_Organism multi-cellular organism - animal uberon Koerper body @@ -16127,12 +16326,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An multi-cellular organism CARO:0000012 - - - - animal - BTO:0000042 - @@ -16539,7 +16732,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -16761,7 +16954,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -16817,7 +17010,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -16876,7 +17069,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An basal lamina of epithelium - Basal:lamina.jpg + https://upload.wikimedia.org/wikipedia/commons/6/65/Basal_lamina.jpg @@ -16985,7 +17178,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? epithelium - Tkanka:nablonkowa.png + https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg @@ -17230,7 +17423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An simple squamous epithelium - Illu:epithelium.jpg + https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg @@ -17430,7 +17623,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side. - UBERON:Commissure-MA_0002723 BAMS:FC BAMS:FG BAMS:cfx @@ -17447,7 +17639,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369115003 UMLS:C0228287 Wikipedia:Commissure_of_fornix - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=273 + neuronames:273 commissura hippocampi commissure of fornix of forebrain delta fornicis @@ -17708,7 +17900,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:16 MA:0000029 MAT:0000298 - MESH:A01.047 + MESH:D000005 MIAA:0000298 OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA SCTID:302553009 @@ -17803,7 +17995,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An embryo https://github.com/obophenotype/uberon/issues/503 - Wrinkledfrog:embryos.jpg + https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg @@ -17856,7 +18048,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00000110 FMA:69069 GAID:1303 - MESH:A16.254.425 + MESH:D005855 NCIT:C12950 NCIT:C54105 TAO:0001122 @@ -17955,7 +18147,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1304 MAT:0000155 MAT:0000173 - MESH:A16.254.425.273 + MESH:D004475 MIAA:0000173 NCIT:C12703 SCTID:362851007 @@ -18051,7 +18243,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:69071 GAID:1305 MAT:0000175 - MESH:A16.254.425.407 + MESH:D004707 MIAA:0000175 NCIT:C12706 SCTID:362855003 @@ -18147,7 +18339,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:69072 GAID:522 MAT:0000174 - MESH:A16.254.425.660 + MESH:D008648 MIAA:0000174 NCIT:C12750 SCTID:362854004 @@ -18588,6 +18780,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris). + In all vertebrates the thin structure that connects the two halves of the telencephalon shows a ridge-like thickening at the basal side known as the anterior commissure.[well established][VHOG] BAMS:AC BAMS:AG @@ -18611,7 +18804,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001558 Wikipedia:Anterior_commissure ZFA:0001108 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=205 + neuronames:205 anterior cerebral commissure commissura anterior cerebri commissura rostralis @@ -18624,6 +18817,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An precommisure rostral commissure UBERON:0000935 + @@ -18754,7 +18948,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0152327 Wikipedia:Posterior_commissure ZFA:0000320 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=484 + neuronames:484 caudal commissure epithalamic commissure uberon @@ -18808,7 +19002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=484 + neuronames:484 BIRNLEX:1026 @@ -18868,6 +19062,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0004658 FBbt:00001761 MAT:0000064 + MESH:D060227 MIAA:0000064 Wikipedia:Imaginal_disc uberon @@ -18942,7 +19137,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Optic_nerve XAO:0000188 ZFA:0000435 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=289 + neuronames:289 02 optic nerve cranial II nervus opticus @@ -19045,7 +19240,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=289 + neuronames:289 BIRNLEX:1640 @@ -19133,7 +19328,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:293 MA:0000353 MAT:0000051 - MESH:A03.492.766 + MESH:D013270 MIAA:0000051 NCIT:C12391 OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA @@ -19158,7 +19353,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stomach - Stomach:diagram.svg + https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg @@ -19270,6 +19465,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A membranous fold of the heart that prevents reflux of fluid. + One of the four structures within the heart that prevent backflow of blood by opening and closing with each heartbeat. The valves include two semilunar valves, the aortic and pulmonary; the mitral or bicuspid valve; and the tricuspid valve. The valves permit blood flow in only one direction. [TFD][VHOG] Extensive conservation of valve developmental mechanisms also has been observed among vertebrate species including chicken, mouse, and human.[well established][VHOG] Rector et al: One might be tempted to define 'heart valve' equivalently to 'valve in the heart', and 'valve' as a 'structure which functions as a valve'. But this combination results in the 'foramen ovale' being classified as a kind of 'heart valve', since it is undoubtedly located in the heart and functions as a valve @@ -19299,6 +19495,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stomodaeal valve valvule UBERON:0000946 + @@ -19378,6 +19575,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae. + The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO] When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG] aortic @@ -19410,10 +19608,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000947 + aorta - Aorta:scheme.jpg + https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg @@ -19464,7 +19663,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001523 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -19513,6 +19712,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] @@ -19550,6 +19750,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cardium UBERON:0000948 + @@ -19737,6 +19938,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. requires review for applicability to invertebrate structures, e.g. synganglion + Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) @@ -19778,7 +19980,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0000010 ZFA:0000008 galen:Brain - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 + neuronames:21 uberon encephalon suprasegmental levels of nervous system @@ -19788,6 +19990,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000955 + @@ -19884,7 +20087,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 + neuronames:21 BIRNLEX:796 @@ -19934,6 +20137,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex. We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus). + The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]. Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG] hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743] @@ -19957,7 +20161,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000185 MAT:0000108 MBA:688 - MESH:A08.186.211.730.885.213 + MESH:D002540 MIAA:0000108 NCIT:C12443 PBA:128011354 @@ -19965,7 +20169,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0007776 VHOG:0000722 Wikipedia:Cerebral_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39 + neuronames:39 cortex of cerebral hemisphere uberon brain cortex @@ -19976,6 +20180,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pallium of the brain UBERON:0000956 + cerebral cortex @@ -20049,7 +20254,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39 + neuronames:39 BIRNLEX:1494 @@ -20189,7 +20394,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Optic_chiasm XAO:0004071 ZFA:0000556 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=459 + neuronames:459 chiasma opticum decussation of optic nerve fibers optic chiasm @@ -20208,7 +20413,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A decussation of the diencephalon where the fibers of the optic nerve cross. - MGI:llw2 + MGI:llw2 MP:0009770 Wikipedia:Optic_chiasm http://orcid.org/0000-0002-6601-2165 @@ -20247,7 +20452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=459 + neuronames:459 BIRNLEX:1416 @@ -20295,7 +20500,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - @@ -20329,6 +20533,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. + corneal Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water AAO:0010344 @@ -20358,6 +20563,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tunica cornea UBERON:0000964 + @@ -20457,6 +20663,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Transparent part of camera-type eye that helps to refract light to be focused on the retina. + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] This class excludes compound eye corneal lenses. AAO:0010348 @@ -20468,7 +20675,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:58241 MA:0000275 MAT:0000141 - MESH:A09.371.509 + MESH:D007908 MIAA:0000141 NCIT:C12743 OpenCyc:Mx4rvVj0fZwpEbGdrcN5Y29ycA @@ -20489,6 +20696,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lenses ocular lens UBERON:0000965 + @@ -20589,6 +20797,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO] The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] retinal @@ -20620,7 +20829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Retina XAO:0000009 ZFA:0000152 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1862 + neuronames:1862 inner layer of eyeball retina of camera-type eye tunica interna of eyeball @@ -20629,6 +20838,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An retinas UBERON:0000966 + @@ -20725,6 +20935,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An organ that detects light. This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each) + ocular optic Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva, @@ -20746,6 +20957,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0000970 + @@ -20803,14 +21015,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt + FBbt The paired, usually multiple jointed, sensory organs articulating on the procephalic region of the head capsule; its highly versatile sensory structures are capable to detect the various environmental stimuli. In the context of Drosophila refers to they are the most anterior segmented sensory appendage of the head. FB:gg - ISBN:3110148986 + ISBN:3110148986 Wikipedia:Antenna_(biology) @@ -20862,7 +21074,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An neck - Female:neck.jpg + https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg @@ -21047,7 +21259,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:13303 GAID:183 MA:0001356 - MESH:A02.835.232.087.412 + MESH:D006811 NCIT:C12731 SCTID:181923006 UMLS:C0020164 @@ -21103,7 +21315,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001158 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -21123,21 +21335,21 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mesomere 1 of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pectoral fin - ISBN:0226313409 + ISBN:0226313409 @@ -21216,8 +21428,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - BGEE:AN ISBN:978-0030223693 + https://orcid.org/0000-0003-3308-6245 @@ -21290,7 +21502,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000345 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -21330,7 +21542,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:24476 GAID:204 MA:0001361 - MESH:A02.835.232.500.883 + MESH:D013977 NCIT:C12800 OpenCyc:Mx4rvtq3-ZwpEbGdrcN5Y29ycA SCTID:182061009 @@ -21486,7 +21698,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9611 GAID:199 MA:0001359 - MESH:A02.835.232.500.247 + MESH:D005269 NCIT:C12717 OpenCyc:Mx4rvVjOJJwpEbGdrcN5Y29ycA SCTID:182046008 @@ -21561,7 +21773,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001159 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -21580,7 +21792,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mesomere 1 of pevlic appendage - ISBN:0226313409 + ISBN:0226313409 @@ -21608,14 +21820,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An proximal metapterygial mesomere of pelvic appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pelvic fin - ISBN:0226313409 + ISBN:0226313409 @@ -21778,7 +21990,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hind metapodium AAO:0000221 - MA:th + MA:th http://en.wiktionary.org/wiki/metapodial @@ -21898,6 +22110,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved + The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG] During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG] BAMS:PONS @@ -21925,13 +22138,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1280999 VHOG:0001176 Wikipedia:Pons - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=547 + neuronames:547 pons Varolii pons of Varolius uberon pons cerebri UBERON:0000988 + pons @@ -21995,7 +22209,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=547 + neuronames:547 BIRNLEX:733 @@ -22369,6 +22583,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The gonad of a female organism which contains germ cells. + Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO] Female reproductive organ.[TAO] (...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG] @@ -22427,13 +22642,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ovarium UBERON:0000992 + ovary - Female:anatomy.png http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png @@ -22775,6 +22991,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth. + The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG] An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG] uterine @@ -22801,12 +23018,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0000995 + uterus - Female:anatomy.png http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png @@ -23017,8 +23235,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mammalian vulva puboperineal region pudendum femininum - skin of female pudendum - skin of vulva vulva uberon pudendum @@ -23059,6 +23275,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An female pudendum BTO:0003101 FMA:20462 + doi:10.1002/ca.23705 + @@ -23072,7 +23290,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pudendum femininum FMA:20462 FMA:TA - + doi:10.1002/ca.23705 + @@ -23085,19 +23304,24 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pudendum BTO:0003101 + doi:10.1002/ca.23705 + pudendum femininum Wikipedia:Vulva - + doi:10.1002/ca.23705 + pudendum muliebre BTO:0003101 + doi:10.1002/ca.23705 + @@ -23373,6 +23597,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outer epithelial layer of the skin that is superficial to the dermis. + A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] relationship loss: subclass external integument structures (AAO:0000961)[AAO] @@ -23405,6 +23630,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001003 + @@ -23468,6 +23694,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Functional system which consists of structures involved in respiration. + The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] AAO:0000541 @@ -23502,6 +23729,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001004 + @@ -23835,7 +24063,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] AAO:0000959 CALOHA:TS-2103 - FBbt:00005057 OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA VHOG:0001248 Wikipedia:Circulatory_system @@ -24043,6 +24270,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + Connective tissue in which fat is stored.[TAO] Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] @@ -24083,6 +24311,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fatty depot UBERON:0001013 + @@ -24305,7 +24534,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Nervous_system XAO:0000177 ZFA:0000396 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3236 + neuronames:3236 neurological system nerve net uberon @@ -24337,7 +24566,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. BIRNLEX:844 ISBN:0-14-051288-8 - ISBN:3110148986 + ISBN:3110148986 NLM:nervous+system WB:rynl Wikipedia:Nervous_system @@ -24449,7 +24678,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Central_nervous_system XAO:0000215 ZFA:0000012 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=854 + neuronames:854 CNS systema nervosum centrale cerebrospinal axis @@ -24467,7 +24696,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt + FBbt cjm @@ -24714,7 +24943,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An White matter fiber bundle that crosses the midline of the brain or spinal cord, that connects similar structures on both sides. (CUMBO; Heimer, L. The Human Brain, 2nd ed., 1995, pg 6) commissural commissure - FBbt:00005103 FMA:83906 NCIT:C32349 NLX:110 @@ -24785,6 +25013,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + A portion of tissue which is a fasiculated group of axons.[TAO] nervous AAO:0011070 @@ -24830,6 +25059,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon neural subtree UBERON:0001021 + @@ -24839,7 +25069,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt + FBbt @@ -25135,7 +25365,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Gustatory_system XAO:0003197 ZFA:0001101 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2889 + neuronames:2889 gustatory organ system taste system uberon @@ -25318,7 +25548,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16085 FMA:87180 GAID:1301 - MESH:A16.254.403.981 + MESH:D015017 NCIT:C14128 SCTID:362845002 UMLS:C0043425 @@ -25518,7 +25748,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:46688 GAID:155 MA:0000432 - MESH:A03.867 + MESH:D010614 NCIT:C12425 OpenCyc:Mx4rvViv7ZwpEbGdrcN5Y29ycA SCTID:181211006 @@ -25678,7 +25908,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:291 MA:0000352 MAT:0000048 - MESH:A03.365 + MESH:D004947 MIAA:0000048 NCIT:C12389 OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA @@ -26020,7 +26250,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Large synaptic bouton found in areas like olfactory bulb, cerebellar cortex and thalamus, that contacts many post-synaptic targets[NIF]. - UBERON:FBbt_00005386 glomerulus FBbt:00005386 NIF_Subcellular:sao587858733 @@ -26148,6 +26377,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16757 FMA:293882 MAT:0000069 + MESH:D054259 MIAA:0000069 NCIT:C34226 SCTID:362852000 @@ -26157,7 +26387,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Neural_tube XAO:0003204 ZFA:0001135 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1365 + neuronames:1365 uberon neural primordium presumptive central nervous system @@ -26253,7 +26483,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:54880 GAID:338 MA:0001796 - MESH:A03.867.490 + MESH:D007013 NCIT:C12246 OpenCyc:Mx4rvq5O0JwpEbGdrcN5Y29ycA SCTID:281490009 @@ -26269,7 +26499,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hypopharynx - Illu:pharynx.jpg + https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg @@ -26344,6 +26574,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The terminal portion of the intestinal tube, terminating with the anus. + The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] rectal In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html @@ -26359,7 +26590,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:311 MA:0000336 MAT:0000050 - MESH:A03.492.411.495.767 + MESH:D012007 MIAA:0000050 NCIT:C12390 OpenCyc:Mx4rvVjaU5wpEbGdrcN5Y29ycA @@ -26376,6 +26607,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An terminal portion of large intestine UBERON:0001052 + rectum @@ -26558,7 +26790,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An enlarged in pterosaurs At its base, the flocculus receives input from the middle ears vestibular system and regulates balance. Many floccular projections descend to the spinal cord and connect to the motor nuclei involved in control of eye movement. flocculus is an exact label for two distinct classes in NIF. - UBERON:Flocculus-MA_0000992 BAMS:FL BAMS:Fl BIRNLEX:1329 @@ -26571,7 +26802,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279368002 SCTID:30711003 Wikipedia:Flocculus_(cerebellar) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=680 + neuronames:680 flocculus of cerebellum neuraxis flocculus uberon @@ -26789,7 +27020,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:10446 GAID:105 MA:0000110 - MESH:A02.165.410 + MESH:D007403 NCIT:C49571 OpenCyc:Mx4rv11AcpwpEbGdrcN5Y29ycA SCTID:244570000 @@ -26931,6 +27162,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. + not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO AAO:0010218 AAO:0010416 @@ -26954,6 +27186,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria carotis externa UBERON:0001070 + @@ -27022,6 +27255,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. + Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]. Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] AAO:0011083 @@ -27047,6 +27281,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An postcava vena cava inferior UBERON:0001072 + posterior vena cava @@ -28171,7 +28406,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1260 MA:0000348 MAT:0000041 - MESH:A14.254.860 + MESH:D014070 MIAA:0000041 NCIT:C12506 OpenCyc:Mx4rvVjUEZwpEbGdrcN5Y29ycA @@ -28271,7 +28506,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:12519 GAID:236 MA:0001421 - MESH:A02.835.232.834.151.213 + MESH:D001270 NCIT:C32239 SCTID:181818007 TAO:0001167 @@ -28307,7 +28542,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000709 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -28477,7 +28712,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Sacrum XAO:0003078 galen:SacralVertebra - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1706 + neuronames:1706 sacral segment segment of sacrum uberon @@ -28499,7 +28734,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000552 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -28746,7 +28981,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm @@ -28789,7 +29024,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:12823 GAID:1263 MA:0000349 - MESH:A14.254.860.425 + MESH:D007180 NCIT:C32769 OpenCyc:Mx4rwP1ch5wpEbGdrcN5Y29ycA SCTID:420856006 @@ -28851,7 +29086,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pectoralis minor - Pectoralis:minor.png + https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png @@ -29055,7 +29290,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An clavicle bone - Pectoral:girdles-en.svg + https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg @@ -29272,7 +29507,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Dorsal group[Kardong] latissimus dorsi muscle - Latissimus:dorsi.png + https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png @@ -29358,7 +29593,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An serratus ventralis - Serratus:anterior.png + https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png @@ -29899,7 +30134,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An skeletal muscle tissue - Skeletal:muscle.jpg + https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg @@ -29971,7 +30206,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2:0003141 EMAPA:32717 EV:0100378 - FBbt:00003525 FMA:14070 GAID:167 MA:0000166 @@ -30003,7 +30237,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An smooth muscle tissue - Glatte:Muskelzellen.jpg + https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg @@ -30139,7 +30373,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EFO:0001405 FMA:14181 GAID:30 - MESH:A01.176 + MESH:D001415 NCIT:C13062 OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA SCTID:123961009 @@ -30190,6 +30424,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava. + The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]. in EHDAA2, the renal vein is part of the kidney BTO:0002681 @@ -30212,6 +30447,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon venae renales UBERON:0001140 + renal vein @@ -30270,6 +30506,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A renal vein that drains the right kidney. + A vein that drains blood from the right kidney into the inferior vena cava[ncithesaurus]. EMAPA:37381 FMA:14335 @@ -30280,6 +30517,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0508000 uberon UBERON:0001141 + right renal vein @@ -30315,6 +30553,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A renal vein that drains the left kidney. + A vein that drains blood from the left kidney into the inferior vena cava[ncithesaurus]. EMAPA:37166 FMA:14336 @@ -30325,6 +30564,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0508001 uberon UBERON:0001142 + left renal vein http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png @@ -30464,7 +30704,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14539 GAID:290 MA:0000355 - MESH:A03.159.183.419 + MESH:D003549 NCIT:C32421 OpenCyc:Mx4rveBeC5wpEbGdrcN5Y29ycA SCTID:245398005 @@ -30560,6 +30800,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction. + caecal A cecum is present in most amniote species, and also in lungfish, but not in any living species of amphibian. In reptiles, it is usually a single median structure, arising from the dorsal side of the large intestine. Birds typically have two paired ceca, as, unlike other mammals, do hyraxes. Most mammalian herbivores have a relatively large cecum, hosting a large number of bacteria, which aid in the enzymatic breakdown of plant materials such as cellulose; in many species, it is considerably wider than the colon. In contrast, obligatory carnivores, whose diets contain little or no plant material, have a reduced cecum, which is often partially or wholly replaced by the vermiform appendix. Many fish have a number of small outpocketings, called pyloric ceca, along their intestine; despite the name they are not homologous with the cecum of amniotes, and their purpose is to increase the overall area of the digestive epithelium.[2] Some invertebrates, such as squid,[3] may also have structures with the same name, but these have no relationship with those of vertebrates. BTO:0000166 @@ -30572,7 +30813,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14541 GAID:307 MA:0000334 - MESH:A03.492.411.495.209 + MESH:D002432 MIAA:0000288 NCIT:C12381 OpenCyc:Mx4rve6u4JwpEbGdrcN5Y29ycA @@ -30593,6 +30834,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An intestinum crassum cecum UBERON:0001153 + Taxon notes: in some herbivorous lizards, a cecum is present between small and large intestines[Kardong] @@ -30729,7 +30971,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000335 MAP:0000001 MAT:0000526 - MESH:A03.492.411.495.356 + MESH:D003106 NCIT:C12382 OpenCyc:Mx4rvgLEM5wpEbGdrcN5Y29ycA SCTID:302508007 @@ -30836,7 +31078,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14559 GAID:320 MA:0001612 - MESH:A03.492.766.419 + MESH:D005748 NCIT:C12257 SCTID:362139007 UMLS:C0017129 @@ -30931,11 +31173,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14561 GAID:319 MA:0001609 - MESH:A03.492.766.163 + MESH:D002299 NCIT:C12256 SCTID:362138004 UMLS:C0007144 - Wikipedia:Cardia + Wikipedia:Cardia cardial part of stomach gastric cardia pars cardiaca (gaster) @@ -30950,14 +31192,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001162 cardia of stomach - Illu:stomach.jpg + https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg The part of the stomach attached to the esophagus. The cardia begins immediately distal to the z-line of the gastroeosphageal junction, where the squamous epithelium of the esophagus gives way to the columnar epithelium of the gastrointestinal tract[WP]. BTO:0000198 - Wikipedia:Cardia + Wikipedia:Cardia @@ -30983,32 +31225,32 @@ A continuant cannot be part of an occurrent: use 'participates in'. An antrum cardiacum - Wikipedia:Cardia + Wikipedia:Cardia antrum cardiacum - Wikipedia:Cardia + Wikipedia:Cardia cardiac orifice - Wikipedia:Cardia + Wikipedia:Cardia cardiac region - Wikipedia:Cardia + Wikipedia:Cardia cardial orifice - Wikipedia:Cardia + Wikipedia:Cardia @@ -31031,7 +31273,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14579 GAID:332 MA:0001624 - MESH:A03.492.766.716 + MESH:D011706 NCIT:C12259 SCTID:362142001 UMLS:C0034193 @@ -31132,7 +31374,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14581 GAID:333 MA:0002560 - MESH:A03.492.766.799 + MESH:D011708 NCIT:C12260 SCTID:362143006 UMLS:C0034196 @@ -31587,6 +31829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. + Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO] The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG] EHDAA2:0000303 @@ -31608,6 +31851,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon ductus choledochus UBERON:0001174 + @@ -31800,6 +32044,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra. + Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon BTO:0002303 EHDAA2:0001949 @@ -31821,6 +32066,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria mesenterica superior UBERON:0001182 + superior mesenteric artery @@ -31867,6 +32113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted]. + IMA BTO:0002302 EHDAA2:0000817 @@ -31887,6 +32134,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria mesenterica inferior UBERON:0001183 + inferior mesenteric artery @@ -31932,6 +32180,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates. renal arteries vary widely even in humans. Sub-structures should be checked for taxon variability. + Artery which supplies blood via branches to the gonads, oviducts, and kidneys.[AAO] The renal arteries normally arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood. Each is directed across the crus of the diaphragm, so as to form nearly a right angle with the aorta. The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys. The arterial supply of the kidneys is variable and there may be one or more renal arteries supplying each kidney. It is located above the renal vein. It has a radius of approximately 0.25cm, 0.26 cm at the root. The measured mean diameter can differ depending on the imaging method used. For example, the diameter was found to be 5.04 ± 0.74 mm using ultrasound, but 5.68 ± 1.19 mm using angiography. [WP,unvetted].[Wikipedia] AAO:0010223 @@ -31960,6 +32209,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal arteries UBERON:0001184 + @@ -32016,6 +32266,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Renal artery that supplies the right kidney. + EMAPA:37380 FMA:14752 MA:0002037 @@ -32027,6 +32278,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An right renal arterial tree uberon UBERON:0001185 + The right [renal artery] passes behind the inferior vena cava, the right renal vein, the head of the pancreas, and the descending part of the duodenum[WP] @@ -32059,6 +32311,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Renal artery that supplies the left kidney. + EMAPA:37098 FMA:14753 MA:0002036 @@ -32070,6 +32323,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An left renal arterial tree uberon UBERON:0001186 + The left [renal artery] is somewhat higher than the right; it lies behind the left renal vein, the body of the pancreas and the splenic vein, and is crossed by the inferior mesenteric vein[WP] left renal artery @@ -32100,6 +32354,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An artery that supplies an ovary. + In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]. EMAPA:18620 FMA:14761 @@ -32113,6 +32368,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria ovarica UBERON:0001190 + ovarian artery http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png @@ -32151,6 +32407,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted]. + EHDAA2:0000311 EHDAA:2553 EMAPA:17310 @@ -32165,6 +32422,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria iliaca communis UBERON:0001191 + See notes for parent class common iliac artery @@ -32216,7 +32474,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:14907 GAID:321 MA:0002683 - MESH:A03.492.766.440 + MESH:D005753 NCIT:C32656 OpenCyc:Mx8NhB4rvcD6KJwpEbGdrcN5Y29ycB4rvmKNOpwpEbGdrcN5Y29ycB4rvVj5FpwpEbGdrcN5Y29ycB4rvVjlqpwpEbGdrcN5Y29ycA SCTID:362131005 @@ -32249,7 +32507,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mucosa of stomach - Wikipedia:File:Normal_gastric_mucosa_intermed_mag.jpg + https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg @@ -33143,7 +33401,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:19028 GAID:950 MA:0000137 - MESH:A10.549.598 + MESH:D010581 NCIT:C12771 UMLS:C0031272 Wikipedia:Peyer's_patch @@ -33250,7 +33508,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:15060 GAID:314 MA:0001551 - MESH:A03.492.411.620.270.322 + MESH:D002011 NCIT:C13010 SCTID:41298001 UMLS:C0006323 @@ -33487,6 +33745,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]. + CALOHA:TS-2230 EMAPA:17948 FMA:15575 @@ -33504,11 +33763,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An p. renallis pyelum UBERON:0001224 + In this ontology, the renal pelvis is represented as the area of part-overlap between the kidney and the ureter renal pelvis - Illu:kidney2.jpg + https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg @@ -33560,6 +33820,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Outer cortical portion of the kidney, between the renal capsule and the renal medulla. + In the adult metanephros, it forms a continuous smooth outer zone with a number of projections that extend down between the pyramids. It contains the renal corpuscles and the renal tubules except for parts of the loop of Henle which descend into the renal medulla. It also contains blood vessels and cortical collecting ducts. The renal cortex is the part of the kidney where ultrafiltration occurs.[WP] BTO:0001166 CALOHA:TS-0503 @@ -33578,10 +33839,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal cortex uberon UBERON:0001225 + cortex of kidney - Illu:kidney.jpg + https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg @@ -33634,6 +33896,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Tip of renal pyramid projecting into a minor calyx. + BTO:0003925 EMAPA:35727 FMA:15622 @@ -33647,10 +33910,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An kidney papilla uberon UBERON:0001228 + renal papilla - Kidney:PioM.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png @@ -33690,6 +33954,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron. + A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney[BTO] A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated. Paired highly vascularized structures of the pronephros, responsible for blood filtration.[XAO] The part of the nephron that filters blood.[TAO] @@ -33715,12 +33980,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cortical renal corpuscle kidney corpuscle UBERON:0001229 + Together, the Bowmans capsule and the glomerulus comprise the definitive renal corpuscle. http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron renal corpuscle - Renal:corpuscle.svg + https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg @@ -33933,7 +34199,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Malpighian capsule - UBERO:cjm + UBERON:cjm @@ -33974,6 +34240,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelial tube that is part of the nephron, the functional part of the kidney. + note that in ISBN:0073040584 (Vertebrates, Kardong), the uriniferous tubule contains the nephron, so we have a separate class, rather than using a synonym, as in MA UBERON:0004210 renal tubule @@ -33998,6 +34265,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uriniferous tubule UBERON:0001231 + @@ -34071,6 +34339,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient. + Renal duct that collects the output from renal tubules.[TAO] in ISBN:0073040584 (Vertebrates, Kardong), the nephron is adjacent to the collecting tubule, consistent with FMA, but not GO. Wikipedia says: Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron BTO:0000761 @@ -34098,6 +34367,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An kidney collecting tubule ureteric tree UBERON:0001232 + @@ -34235,7 +34505,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone. ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0008288 @@ -34323,7 +34593,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine. MESH:A06.407.071.265 - MGI:llw2 + MGI:llw2 MP:0008289 @@ -34504,7 +34774,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:15695 GAID:296 MA:0001537 - MESH:A03.492.411.369 + MESH:D007413 NCIT:C49241 SCTID:362080002 UMLS:C0021839 @@ -34695,16 +34965,16 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. + anal In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html BTO:0001680 CALOHA:TS-2005 EV:0100082 - FBbt:00003148 + FBbt:00047153 FMA:15711 GAID:312 MA:0000331 - MESH:A03.492.411.495.767.288 NCIT:C43362 OpenCyc:Mx4rvVjaEZwpEbGdrcN5Y29ycA SCTID:181262009 @@ -34720,6 +34990,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon proctodeum UBERON:0001245 + anus @@ -34854,7 +35125,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm MA @@ -34872,7 +35143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur. - CL:tm + CL:tm MP:0008470 https://github.com/obophenotype/uberon/issues/6 @@ -34886,31 +35157,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Malpighian body - FMA:15843 + FMA:15843 lymphatic follicle of spleen - FMA:15843 + FMA:15843 lymphoid follicle of spleen - FMA:15843 + FMA:15843 lymphoid nodule of spleen - FMA:15843 + FMA:15843 spleen B cell follicle - CL:tm + CL:tm @@ -34922,13 +35193,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An splenic B cell follicle - CL:tm + CL:tm splenic lymphatic follicle - FMA:15843 + FMA:15843 @@ -34945,6 +35216,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation. + CALOHA:TS-1263 EMAPA:35806 FMA:15844 @@ -34960,6 +35232,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon pulpa splenica UBERON:0001250 + red pulp of spleen @@ -34976,7 +35249,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -35014,6 +35287,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens. + WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line. marginal zone CALOHA:TS-2395 @@ -35027,6 +35301,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An spleen marginal zone uberon UBERON:0001251 + marginal zone of spleen http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png @@ -35078,6 +35353,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder[MP]. + MP treats ureter urothelium and ureter luminal urothelium as exact synonyms, yes MA treats these as distinct; see also: transitional epithelium vs urothelium EMAPA:28089 FMA:15897 @@ -35088,6 +35364,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon ureter luminal urothelium UBERON:0001254 + urothelium of ureter @@ -35133,6 +35410,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]. + A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO] In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG] @@ -35151,7 +35429,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:0000004 MA:0000380 MAT:0000122 - MESH:A05.810.161 + MESH:D001743 MIAA:0000122 NCIT:C12414 OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA @@ -35167,12 +35445,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vesica UBERON:0001255 + urinary bladder - Urinary:system.svg + https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg @@ -35213,7 +35492,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - BGEE:Ann + https://orcid.org/0000-0003-3308-6245 GOTAX:0010073 https://github.com/obophenotype/uberon/issues/454 @@ -35291,6 +35570,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical wall that lines the insider of a urinary bladder. + BTO:0001462 EMAPA:35175 FMA:15902 @@ -35307,6 +35587,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An wall of bladder uberon UBERON:0001256 + wall of urinary bladder @@ -35373,6 +35654,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa. + The area is very sensitive to expansion and once stretched to a certain degree, the urinary bladder signals the brain of its need to empty. The signals become stronger as the bladder continues to fill. Embryologically, the trigone of the bladder is derived from the caudal end of mesonephric ducts, which is of mesodermal origin (the rest of the bladder is endodermal). In the female the mesonephric ducts regresses, causing the trigone to be less prominent, but still present EMAPA:35174 @@ -35395,10 +35677,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An dorsal bladder neck trigonum vesicae urinariae UBERON:0001257 + trigone of urinary bladder - Illu:bladder.jpg + https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg @@ -35536,6 +35819,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The mucous membrane lining the urinary bladder. + EFO:0000293 EMAPA:35897 FMA:15928 @@ -35558,6 +35842,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001259 + mucosa of urinary bladder @@ -35724,6 +36009,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + EMAPA:35651 FMA:16011 MA:0002417 @@ -35736,6 +36022,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pancreatic acinar pancreatic acini UBERON:0001263 + pancreatic acinus @@ -35769,12 +36056,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:16011 - - - - pancreatic acinar - TEMP:MP - @@ -35789,6 +36070,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. + Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO] In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG] pancreatic @@ -35822,6 +36104,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001264 + @@ -35888,6 +36171,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A trabecula that is part of a spleen. + EMAPA:35808 FMA:16027 MA:0000758 @@ -35897,8 +36181,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Trabeculae_of_spleen spleen trabeculum splenic trabecula + trabeculae of spleen uberon UBERON:0001265 + trabecula of spleen @@ -35924,6 +36210,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0229688 ncithesaurus:Splenic_Trabecula + + + + trabeculae of spleen + + @@ -35955,7 +36247,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:16579 GAID:206 MA:0001335 - MESH:A02.835.232.611.108 + MESH:D000077 NCIT:C32042 OpenCyc:Mx4rwJlP9ZwpEbGdrcN5Y29ycA RETIRED_EHDAA2:0001427 @@ -36117,7 +36409,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions. this class describes the subdivision of the limb/fin, NOT the skeleton within. See also: skeleton of pectoral girdle (UBERON:0007831). See also comments on obo-anatomy mail list. Note that even though the class includes soft tissue it is more restrictive than 'pelvis' which also includes structures in cavities etc. TODO this needs to be better documented Subdivision of lower limb or fin which links the limb/fin to the body[FMA,modified]. There is only one instance of the pelvic girdle region per organism.[VSAO] EMAPA:37862 @@ -36137,7 +36429,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions. DOI:10.1002/dvdy.22617 FMA:16581 FMA:23217 @@ -36187,7 +36479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A fused bone consisting of the ilium, ischium and and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]. + A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]. currently this class is restricted to exclude the teleost bone as the definition mentions ilium, ischium and pubis. In future we may add a grouping class for girdle bones that supports the appendage The hip/pelvic bone/basipterygium first appears in fishes, where it consists of a simple, usually triangular bone, to which the pelvic fin articulates. The hip bones on each side usually connect with each other at the forward end, and are even solidly fused in lungfishes and sharks, but they never attach to the vertebral column in FMA this is a paired structure. NCITA has 'pelvic bone' but this is the *superclass* of ilium/ischium/pubis. The MA class 'pelvis bone' is actually a superclass of 'pelvic girdle bone' and caudal/sacral vertebra. @@ -36195,7 +36487,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An innominate FMA:16585 GAID:205 - MESH:A02.835.232.611 SCTID:361776002 Wikipedia:Hip_bone coxal bone @@ -36232,7 +36523,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A fused bone consisting of the ilium, ischium and and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]. + A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified]. Wikipedia:Hip_bone https://github.com/obophenotype/uberon/issues/290 https://orcid.org/0000-0002-6601-2165 @@ -36336,7 +36627,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:16589 GAID:207 MA:0001336 - MESH:A02.835.232.611.434 + MESH:D007085 NCIT:C32765 OpenCyc:Mx4rvhwFJ5wpEbGdrcN5Y29ycA SCTID:182029005 @@ -36471,7 +36762,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:16592 GAID:208 MA:0001337 - MESH:A02.835.232.611.548 + MESH:D007512 NCIT:C32884 OpenCyc:Mx4rvlzMKpwpEbGdrcN5Y29ycA SCTID:182025004 @@ -36523,7 +36814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium. VSAO:0005006 - VSAO:NI + VSAO:NI Wikipedia:Ischium @@ -36596,7 +36887,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:18728 FMA:16595 MA:0001338 - MESH:A02.835.232.611.781 + MESH:D011630 NCIT:C33423 SCTID:182035005 UMLS:C0034014 @@ -36913,6 +37204,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver. FMA:17523 MA:0002499 @@ -36924,10 +37216,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon trias hepatica UBERON:0001279 + portal triad - Portal:triad.JPG + https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG @@ -37067,6 +37360,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. + (...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG] UBERON:0003275 EHDAA2:0000999 @@ -37090,6 +37384,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon hepatic sinusoids UBERON:0001281 + @@ -37182,6 +37477,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. Note that this is part of the intrahepatic bile duct in MA, as this class is more alike the tree in FMA. Note also that SCT has canal of Hering and Entire IBduct as the only sibling terms under 'Structure of intralobular bile duct' (i.e. the CoH is the only part of the entire IBduct) + FMA:17545 MA:0002669 NCIT:C32255 @@ -37198,6 +37494,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An duct of Herring intrahepatic bile ductule UBERON:0001282 + intralobular bile duct @@ -37430,6 +37727,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP]. kidney terms require review for cross-vertebrate compatibility and developmental relationships. + Functional unit of the kidney that filters waste.[TAO] In the avian kidney, three types of nephron are identified: mammalian-type nephrons with long and short loops of Henle, and reptilian type nephrons (Gambaryan, 1992) BTO:0000924 @@ -37452,6 +37750,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nephroneum tubulus renalis UBERON:0001285 + @@ -37887,6 +38186,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure. + descending limb EMAPA:35511 FMA:17705 @@ -37899,6 +38199,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An loop of Henle descending limb uberon UBERON:0001289 + descending limb of loop of Henle @@ -37949,6 +38250,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule. TODO - thick/thin check. Also - does the loop of Henle overlap the distal convoluted tubule? FMA divides DCT into straight and convoluted portions + EMAPA:28396 EMAPA:29671 EMAPA:35512 @@ -37968,6 +38270,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon tubulus rectus distalis UBERON:0001291 + thick ascending limb of loop of Henle @@ -38045,6 +38348,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. + a portion of kidney nephron between the loop of Henle and the collecting duct system[Wikipedia:Distal_convoluted_tubule]. in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. EMAPA:28393 @@ -38062,10 +38366,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tubulus contortus distalis tubulus convolutus distalis UBERON:0001292 + distal convoluted tubule - Kidney:nephron.png + https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png @@ -38204,6 +38509,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Innermost region of the mammalian kidney. + unique to mammals BTO:0001745 CALOHA:TS-0506 @@ -38220,6 +38526,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon kidney inner medulla UBERON:0001294 + inner medulla of kidney @@ -38277,6 +38584,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy. + The mucous membrane lining the uterus. [TFD][VHOG] The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG] endometrial @@ -38306,10 +38614,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uterine mucous membrane UBERON:0001295 + endometrium - Illu:cervix.jpg + https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg @@ -38430,7 +38739,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An myometrium - Illu:cervix.jpg + https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg @@ -38525,7 +38834,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001297 serosa of uterus - Illu:cervix.jpg + https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg @@ -38628,8 +38937,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glans penis - Male:anatomy.png http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg + https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png @@ -38818,7 +39127,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:397 MA:0000397 MAT:0000130 - MESH:A05.360.444.849.286 + MESH:D004822 MIAA:0000130 NCIT:C12328 SCTID:181432000 @@ -38881,15 +39190,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - - - + @@ -38898,6 +39200,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A spherical aggregation of cells in the ovary that contains a single oocyte[WP,modified]. TODO - align subtypes based on staging, which is taxon-specific + Oocyte development of zebrafish has been divided into five stages based on morphological criteria and on physiological and biochemical events. Stage I follicles (less than 140 microns) are primary growth stage, stage II follicles (140-340 microns) are cortical alveolus stage, stage III (340-690 microns) are vitellogenesis, stage IV (690-730 microns) are oocyte maturation, and stage V follicles are matured egg. Selman et al, 1993.[TAO] Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG] These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. These eggs/ova are only developed once every menstrual cycle (e.g. once a month in humans) @@ -38925,12 +39228,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An folliculi ovarici primarii folliculi ovarici vesiculosi UBERON:0001305 + ovarian follicle - Primary:follicle-4.JPG http://upload.wikimedia.org/wikipedia/commons/c/ca/Human_ovarian_follicle.jpg + https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG @@ -39051,6 +39355,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted]. todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships + BTO:0000841 CALOHA:TS-1077 EHDAA:1026 @@ -39070,6 +39375,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon a. umbilicalis UBERON:0001310 + umbilical artery @@ -39110,6 +39416,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb. + mouse sciatic nerve origins predominantly from the third lumbar (L3) and L4 spinal nerves, unlike the L4 and L5 in rats - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700063/ BIRNLEX:1133 BTO:0001221 @@ -39135,6 +39442,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervus sciaticus UBERON:0001322 + sciatic nerve @@ -39541,8 +39849,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An prepuce of penis - Foreskin:CloseupV2.jpg http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg + https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg @@ -39637,7 +39945,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An male urethra - Female:anatomy.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png @@ -39680,7 +39988,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An female urethra - Female:anatomy.png + https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png @@ -39721,6 +40029,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum). + BTO:0003163 EMAPA:30942 FMA:19673 @@ -39736,6 +40045,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon pars prostatica urethrae UBERON:0001335 + prostatic urethra @@ -40024,7 +40334,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C12339 paraurethral gland belongs here - NCIT + NCIT @@ -40345,6 +40655,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:20117 MA:0000058 MAT:0000199 + MESH:D052436 MIAA:0000199 NCIT:C33889 UMLS:C1704223 @@ -40424,7 +40735,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An brown adipose tissue - Brownfat:PETCT.jpg + https://upload.wikimedia.org/wikipedia/commons/6/69/Brownfat_PETCT.jpg @@ -40896,7 +41207,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1181 MA:0002503 MAT:0000499 - MESH:A12.207.268 + MESH:D002555 NCIT:C12692 TAO:0002184 UMLS:C0007806 @@ -41059,14 +41370,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + - - - - - - + + The Sphincter ani externus (external anal sphincter) is a flat plane of muscular fibers, elliptical in shape and intimately adherent to the integument surrounding the margin of the anus. [WP,unvetted]. + EMAPA:18265 FMA:21930 MA:0001531 @@ -41079,9 +41388,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon sphincter ani externus UBERON:0001367 + + Some literature reports don't consider the external anal sphincter to be a true sphincter muscle. external anal sphincter + https://github.com/obophenotype/uberon/issues/2344 http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif @@ -41090,17 +41402,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA - - - - - - - - - - FMA - @@ -41351,7 +41652,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001381 semimembranosus muscle - Semimembranosus:muscle.PNG + https://upload.wikimedia.org/wikipedia/commons/b/bf/Semimembranosus_muscle.PNG @@ -41508,6 +41809,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html. TODO - in MA this is asserted to be part_of BOTH frontal and parietal cortex. in ABA these are disjoint. FMA makes no commitment beyond cerebral cortex. Wikipedia says frontal lobe. Check if species difference or difference in definition. Removed relationship: part_of UBERON:0001872 parietal lobe + The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP] BAMS:M1 @@ -41521,13 +41823,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:224854 MA:0000907 MBA:985 - MESH:A08.186.211.730.885.213.270.548 + MESH:D009044 NCIT:C97339 NLX:143555 SCTID:11931008 UMLS:C0026607 Wikipedia:Primary_motor_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1910 + neuronames:1910 motor cortex uberon Rolando's area @@ -41540,6 +41842,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An somatomotor areas UBERON:0001384 + primary motor cortex @@ -41989,11 +42292,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:682 MA:0000942 MBA:247 - MESH:A08.186.211.730.885.213.863.297 + MESH:D001303 NCIT:C52712 UMLS:C0004302 Wikipedia:Auditory_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1556 + neuronames:1556 uberon A1 (primary auditory cortex) BA41 @@ -42426,7 +42729,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:23463 GAID:185 MA:0001357 - MESH:A02.835.232.087.702 + MESH:D011884 NCIT:C12777 OpenCyc:Mx4rwUsDcZwpEbGdrcN5Y29ycA SCTID:181940002 @@ -42503,7 +42806,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:23466 GAID:188 MA:0001358 - MESH:A02.835.232.087.911 + MESH:D014457 NCIT:C12809 OpenCyc:Mx4rwPtIM5wpEbGdrcN5Y29ycA SCTID:181948009 @@ -42568,7 +42871,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:23709 GAID:180 MA:0002555 - MESH:A02.835.232.087.144.650 + MESH:D021361 NCIT:C12854 OpenCyc:Mx4rwAwWe5wpEbGdrcN5Y29ycA SCTID:181958008 @@ -42667,7 +42970,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:23712 GAID:181 MA:0002556 - MESH:A02.835.232.087.144.663 + MESH:D012667 NCIT:C12786 SCTID:181959000 UMLS:C0036624 @@ -43356,7 +43659,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates - GO + GO @@ -43397,7 +43700,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:23889 GAID:179 MA:0000296 - MESH:A02.835.232.087.144 + MESH:D002348 NCIT:C12688 SCTID:83936004 UMLS:C0007285 @@ -43589,6 +43892,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified]. + Cartilaginous expansion at the distal end of an anterior rib or transverse process that serves for the attachment of muscles suspending the pectoral girdle to the vertebral column.[AAO] Subdivision of long bone which forms its expanded proximal or distal articular end; together with other the subdivisions of long bone, it constitutes the long bone. Examples: proximal epiphysis of humerus, distal epiphysis of femur. epiphyseal @@ -43610,6 +43914,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An long bone epiphysis uberon UBERON:0001437 + epiphysis @@ -43878,7 +44183,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001256 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -44016,7 +44321,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001255 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -44170,14 +44475,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior autopodium VSAO:0005020 - VSAO:NI + VSAO:NI manus VSAO:0005020 - VSAO:NI + VSAO:NI @@ -44206,7 +44511,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:91 MA:0000031 MAT:0000295 - MESH:A01.911 + MESH:D013909 MIAA:0000295 NCIT:C12799 NCIT:C25389 @@ -44411,7 +44716,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pes VSAO:0005021 - VSAO:NI + VSAO:NI @@ -44419,7 +44724,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An posterior autopodium VSAO:0005021 - VSAO:NI + VSAO:NI @@ -44447,7 +44752,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:24479 GAID:202 MA:0001360 - MESH:A02.835.232.500.321 + MESH:D005360 NCIT:C12718 SCTID:302529003 UMLS:C0016068 @@ -44504,7 +44809,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:24491 GAID:194 MA:0000297 - MESH:A02.835.232.300.710 + MESH:D013639 NCIT:C12796 SCTID:108372004 UMLS:C0039316 @@ -44524,7 +44829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tarsal bone - Ankle:en.svg + https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg @@ -44631,7 +44936,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:24492 GAID:193 MA:0000303 - MESH:A02.835.232.300.492 + MESH:D008682 NCIT:C12752 SCTID:302532000 UMLS:C0025584 @@ -44835,7 +45140,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:19134 FMA:24496 MA:0001348 - MESH:A02.835.232.300.710.300 + MESH:D002111 NCIT:C32250 SCTID:182099002 UMLS:C0006655 @@ -44855,7 +45160,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An calcaneus - Subtalar:Joint.PNG + https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG @@ -44966,7 +45271,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The oval-shaped tarsal bone found between the talus and the 3 cuneiform bones. - MGI:llw2 + MGI:llw2 MP:0009727 @@ -45210,7 +45515,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17413 GAID:52 MA:0000033 - MESH:A01.378.800 MESH:D001132 OpenCyc:Mx4rvVjp5ZwpEbGdrcN5Y29ycA VHOG:0000339 @@ -45238,7 +45542,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000339 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -45295,7 +45599,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An elbow - Elbow:coude.JPG + https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG @@ -45376,8 +45680,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An manual digit 1 - Thumbs:up.jpg http://upload.wikimedia.org/wikipedia/commons/6/64/Thumb-up.jpg + https://upload.wikimedia.org/wikipedia/commons/2/2c/Thumbs_up.jpg @@ -45600,6 +45904,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod. + BTO:0003595 CALOHA:TS-2220 EHDAA2:0000895 @@ -45618,6 +45923,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001465 + knee @@ -45974,6 +46280,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO]. + A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO] A vessel that contains or conveys lymph.[AAO] Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG] @@ -45985,6 +46292,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:30315 MA:0000138 MAT:0000443 + MESH:D042601 NCIT:C33038 OpenCyc:Mx4rwA1fYZwpEbGdrcN5Y29ycA SCTID:279089004 @@ -45998,6 +46306,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vas lymphaticum UBERON:0001473 + @@ -46627,6 +46936,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted]. + EFO:0001957 EMAPA:19137 FMA:35175 @@ -46645,6 +46955,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An articulatio genus UBERON:0001485 + knee joint @@ -46972,7 +47283,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An This currently groups the major and minor muscles (which have different attachment sites) as well as the AAO structure: Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus pectoral muscle - Pectoralis:major.png + https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png @@ -47052,6 +47363,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + EHDAA2:0000147 EHDAA:9828 EMAPA:17014 @@ -47068,6 +47380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An aorta ascendens pars ascendens aortae UBERON:0001496 + ascending aorta @@ -47587,6 +47900,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. Do not confuse with aortic arch + The curving portion between the ascending aorta and the descending aorta, giving rise to the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery. [TFD][VHOG] The double systemic arch arches (left and right) present in amphibians and reptiles become reduced to a single systemic arch - the right in birds, the left in mammals.[well established][VHOG] birds have right aortic arch, mammals left. @@ -47605,6 +47919,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An aortic arch thoracic aorta UBERON:0001508 + arch of aorta @@ -47700,7 +48015,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Dorsal group derivative that acts on the forearm[Kardong] triceps brachii - Triceps:brachii.png + https://upload.wikimedia.org/wikipedia/commons/8/83/Triceps_brachii.png @@ -47813,6 +48128,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + results from fusion of left and right dorsal aortae EMAPA:18606 FMA:3784 @@ -47827,6 +48143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An aorta descendens pars descendens aortae UBERON:0001514 + descending aorta @@ -47983,6 +48300,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates + BTO:0002976 EFO:0002524 EMAPA:17856 @@ -48005,6 +48323,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pars abdominalis aortae UBERON:0001516 + abdominal aorta @@ -48173,7 +48492,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An radio-ulnar joint - Forearm:labeled.png + https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png @@ -48207,6 +48526,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. + innominate EFO:0002550 EHDAA2:0000835 @@ -48228,6 +48548,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An truncus brachiocephalicus UBERON:0001529 + brachiocephalic artery @@ -48296,6 +48617,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery' This class represents the adult and developing structures' + in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae carotid artery CALOHA:TS-0116 @@ -48317,6 +48639,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon a. carotis communis UBERON:0001530 + common carotid artery plus branches @@ -48399,6 +48722,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP]. + Each of two arteries starting at the bifurcation of the common carotid arteries through which blood circulates to many structures and organs in the head. [TFD][VHOG] One of the major arteries of the head, it is the as the cranial continuation of the aortic arches and the dorsal aorta. It curves ventrally before resuming a dorsal course as it enters the head proper, and it lies ventral to the internal jugular vein. The internal carotid artery gives off palatine, ophthalmic, and cerebral branches by stage NF stage 41.[AAO] AAO:0010219 @@ -48429,6 +48753,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria carotis interna UBERON:0001532 + @@ -48529,6 +48854,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO) + Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO] In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP] The pectoral (subclavian) arteries originate from the dorsal aorta and takes the blood outward into the fin from the paired portion of the dorsal aorta posterior to the last aortic arch. Kimmel et al. 1993[TAO] @@ -48556,6 +48882,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PA arteria subclavia UBERON:0001533 + @@ -48651,6 +48978,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The subclavian artery that supplies the right pectoral appendage. + in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery proximal part arises from right 4th aortic arch in humans EHDAA2:0004514 @@ -48666,6 +48994,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria subclavia dextra uberon UBERON:0001534 + right subclavian artery @@ -48705,6 +49034,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck. + EHDAA2:0002192 EHDAA:5328 EMAPA:17314 @@ -48724,12 +49054,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria vertebralis vertebral arteries UBERON:0001535 + The two vertebral arteries and the basilar artery are sometimes together called the vertebrobasilar system, which supplies blood to the posterior part of circle of Willis and anastomoses with blood supplied to the anterior part of the circle of Willis from the carotid arteries. [WP,unvetted] vertebral artery - Vertebral:artery.png + https://upload.wikimedia.org/wikipedia/commons/f/ff/Vertebral_artery.png @@ -48790,7 +49121,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm @@ -48820,6 +49151,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The lymph nodes which drain the legs; contained in the popliteal fossa. + In the popliteal fossa between biceps femoris m. and semitendinosus m.. FMA:44227 MA:0000738 @@ -48832,6 +49164,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An popliteal lymph glands popliteal lymph node UBERON:0001543 + popliteal lymph node @@ -48841,7 +49174,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm @@ -48855,7 +49188,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In the popliteal fossa between biceps femoris m. and semitendinosus m.. - PMID:16624319 + PMID:16624319 NCBITaxon:10090 @@ -48897,6 +49230,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries. + arcuate artery EMAPA:28215 FMA:70497 @@ -48905,6 +49239,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal arcuate artery uberon UBERON:0001552 + kidney arcuate artery @@ -49149,6 +49484,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + EHDAA2:0001036 EMAPA:16738 FMA:45662 @@ -49160,6 +49496,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lower respiratory system uberon UBERON:0001558 + lower respiratory tract @@ -49221,7 +49558,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Taxon motes: mylohyoideus and digastricus anterior of rats derived from intermandibularis posterior, see e.g. Jarvik [53] http://www.biomedcentral.com/1471-213X/8/24/table/T3 mylohyoid muscle - Mylohyoid:muscle.PNG + https://upload.wikimedia.org/wikipedia/commons/9/92/Mylohyoid_muscle.PNG @@ -49309,7 +49646,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001565 geniohyoid muscle - Geniohyoid:muscle.PNG + https://upload.wikimedia.org/wikipedia/commons/2/2c/Geniohyoid_muscle.PNG @@ -49400,7 +49737,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cheek - Chica:cachetona.jpg + https://upload.wikimedia.org/wikipedia/commons/a/a9/Chica_cachetona.jpg @@ -49651,7 +49988,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:18277 FMA:46691 MA:0002317 - MFMO_0000064 + MFMO:0000064 NCIT:C53161 SCTID:244785008 UMLS:C0224196 @@ -50207,6 +50544,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]. + Nerve that carries information from the olfactory epithelium through the olfactory bulb to the olfactory cortex of the telencephalon.[AAO] Segment of neural tree organ which is continuous with the olfactory epithelium and an olfactory bulb[FMA:46787]. The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB[MESH:A08.800.800.120.640]. @@ -50237,7 +50575,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Olfactory_nerve XAO:0000426 ZFA:0000249 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=32 + neuronames:32 first cranial nerve nervus olfactorius [i] olfactory I @@ -50253,6 +50591,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An olfactoria fila olfactory fila UBERON:0001579 + @@ -50305,7 +50644,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000703 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -50337,7 +50676,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=32 + neuronames:32 BIRNLEX:1319 @@ -50575,6 +50914,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The subclavian artery that supplies the left pectoral appendage. + in humans, branches off the arch of aorta arises from left intersegmental 6th artery in the region of the 6th -7th cervical segment in humans EMAPA:37100 @@ -50589,6 +50929,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria subclavia (sinistra) uberon UBERON:0001584 + left subclavian artery @@ -50628,6 +50969,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. + Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG] The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green). BTO:0002683 @@ -50652,6 +50994,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vena cava superior vena maxima UBERON:0001585 + anterior vena cava @@ -50726,6 +51069,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO] AAO:0010236 EHDAA2:0000877 @@ -50746,6 +51090,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon vena jugularis interna UBERON:0001586 + internal jugular vein http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png @@ -50799,6 +51144,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava[MP]. check development relationships in different species + EMAPA:18250 FMA:4838 GAID:528 @@ -50812,10 +51158,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon vena azygos UBERON:0001594 + azygos vein - Azygos:vein.png + https://upload.wikimedia.org/wikipedia/commons/b/b4/Azygos_vein.png @@ -51514,6 +51861,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP]. + Part of the external carotid which supplies blood to the tongue.[AAO] relationship loss: part_of external carotid (AAO:0010218)[AAO] AAO:0010492 @@ -51529,9 +51877,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria lingualis UBERON:0001610 + lingual artery - Lingual:artery.PNG + https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG @@ -51577,6 +51926,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + EMAPA:19213 FMA:49549 MA:0001950 @@ -51589,6 +51939,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria maxillaris externa external maxillary artery UBERON:0001612 + facial artery http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png @@ -51622,6 +51973,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified]. + Part of internal carotid which carries blood via branches to the eye, the eye muscles, and eyelids.[AAO] relationship loss: part_of internal carotid (AAO:0010219)[AAO] AAO:0010497 @@ -51642,6 +51994,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria ophthalmica opthalmic artery UBERON:0001619 + ophthalmic artery http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png @@ -51697,6 +52050,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted]. + EMAPA:37113 FMA:49879 GAID:508 @@ -51713,9 +52067,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteria centralis retinae central artery of the retina UBERON:0001620 + central retinal artery - Gray514:updated.png + https://upload.wikimedia.org/wikipedia/commons/5/59/Gray514_updated.png @@ -51817,6 +52172,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted]. + EMAPA:37094 FMA:49927 MA:0001988 @@ -51827,6 +52183,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon a. lacrimalis UBERON:0001622 + lacrimal artery http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png @@ -51864,6 +52221,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted]. + EMAPA:35292 FMA:50000 MA:0001945 @@ -51876,6 +52234,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria dorsalis nasi UBERON:0001623 + dorsal nasal artery http://upload.wikimedia.org/wikipedia/commons/3/35/Gray515.png @@ -51937,7 +52296,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:50095 GAID:813 MA:0002463 - MESH:A08.800.550.700.120.600.150 + MESH:D002344 NCIT:C66852 SCTID:362586000 UMLS:C0007277 @@ -52077,6 +52436,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins. placement of the ZFA class here is dubious + Lymphatic trunk that connects all tributaries of the thoracic duct tree to the trunk of the left brachiocephalic vein. The thoracic duct is the first perfused lymphatic, located between the dorsal aorta and posterior cardinal vein. EHDAA2:0004501 @@ -52084,7 +52444,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:5031 GAID:1290 MA:0002801 - MESH:A15.382.520.869 + MESH:D013897 NCIT:C33768 SCTID:362600004 TAO:0005110 @@ -52095,6 +52455,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon ductus thoracicus UBERON:0001631 + @@ -52175,6 +52536,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain. + Artery that runs along the ventral keel of the hindbrain. It lies between the primordial hindbrain channels(PHBC). It irrigates the hindbrain and is connected, through the hindbrain, to the PHBC by the central arteries. The unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear[MP]. The major artery supplying the hindbrain, the basilar artery, runs along the ventral keel of the hindbrain in all vertebrates.[well established][VHOG] @@ -52196,6 +52558,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon BA UBERON:0001633 + @@ -52218,7 +52581,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain. - BGEE:ann + https://orcid.org/0000-0003-3308-6245 @@ -52260,6 +52623,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] arterial + Some arthropods have primitive arterial systems but this term refers to arteries in a true closed circulatory system. AAO:0010211 AEO:0000208 @@ -52454,6 +52818,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. + Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG] In humans A vein in the abdominal cavity that drains blood from the gastrointestinal tract and spleen. It is usually formed by the confluence of the superior mesenteric and splenic veins, and also receives blood from the inferior mesenteric, gastric, and cystic veins. The hepatic portal vein is a major component of the hepatic portal system, one of the main portal venous systems in the body. Conditions involving the hepatic portal vein cause considerable illness and death. An important example of such a condition is elevated blood pressure in the hepatic portal vein. This condition, called portal hypertension, is a major complication of cirrhosis worldwide. [WP,unvetted] AAO:0010214 @@ -52473,6 +52838,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An primary hepatic portal veins vena portae hepatis UBERON:0001639 + @@ -52542,6 +52908,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The first major branch of the abdominal aorta. + EHDAA2:0004519 EMAPA:35202 FMA:50737 @@ -52564,6 +52931,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An truncus coeliacus truncus cœliacus UBERON:0001640 + dorsal aorta in Kardong @@ -52660,6 +53028,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles. + Somatic efferent fibers which innervate four eye muscles.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] 3n @@ -52686,7 +53055,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Oculomotor_nerve XAO:0003090 ZFA:0000405 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=488 + neuronames:488 nervus oculomotorius nervus oculomotorius [III] oculomotor III @@ -52701,6 +53070,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An occulomotor oculomotor nerve or its root UBERON:0001643 + @@ -52741,7 +53111,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000692 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -52767,7 +53137,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=488 + neuronames:488 BIRNLEX:1646 @@ -52811,6 +53181,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cranial nerve that runs to the eye muscles. + Somatic efferent nerve which supplies a single eye muscle, the m. obliquus superior.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] Homologous trochlear nerves are found in all jawed vertebrates @@ -52839,7 +53210,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Trochlear_nerve XAO:0003091 ZFA:0000600 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=466 + neuronames:466 cranial nerve IV fourth cranial nerve nervus trochlearis [IV] @@ -52856,11 +53227,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An trochlear nerve or its root trochlear nerve/root UBERON:0001644 + trochlear nerve - Trochlear:nerve.png + https://upload.wikimedia.org/wikipedia/commons/3/33/Trochlear_nerve.png @@ -52885,7 +53257,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000705 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -52911,7 +53283,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=466 + neuronames:466 BIRNLEX:1654 @@ -52980,6 +53352,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). + Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls @@ -53011,7 +53384,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Trigeminal_nerve XAO:0003092 ZFA:0000697 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=549 + neuronames:549 fifth cranial nerve nervus trigeminus nervus trigeminus [v] @@ -53027,11 +53400,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An trigeminus UBERON:0001645 + trigeminal nerve - Gray778:Trigeminal.png + https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png @@ -53056,7 +53430,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000704 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -53088,7 +53462,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=549 + neuronames:549 BIRNLEX:869 @@ -53144,6 +53518,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that runs to the eye muscles. + Somatic motor nerve which bifurcates innervating m. rectus lateralis and m. retractor bulbi (eye muscles).[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] Homologous abducens nerves are found in all vertebrates except lampreys and hagfishes.[WP] It controls the movement of a single muscle, the lateral rectus muscle of the eye, in humans. In most other mammals it also innervates the musculus retractor bulbi, which can retract the eye for protection @@ -53169,7 +53544,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Abducens_nerve XAO:0003093 ZFA:0000310 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=550 + neuronames:550 abducens VI nerve abducens nerve [VI] abducens nerve tree @@ -53187,11 +53562,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nerve VI nervus abducens UBERON:0001646 + abducens nerve - Abducens:nerve1.png + https://upload.wikimedia.org/wikipedia/commons/2/29/Abducens_nerve1.png @@ -53227,7 +53603,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000697 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -53259,7 +53635,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=550 + neuronames:550 BIRNLEX:876 @@ -53309,6 +53685,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches). + Slender nerve composed of branchiomotor and visceral efferent fibers innervating the mouth and various muscles within the jaw. Sensory components innervate the bucccal roof and somatomotor components innervate the depressor musculature and muscle interhyoideus.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] 7n @@ -53337,7 +53714,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Facial_nerve XAO:0003094 ZFA:0000664 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=551 + neuronames:551 branchiomeric cranial nerve face nerve facial VII @@ -53356,6 +53733,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nerve VII nervus facialis UBERON:0001647 + @@ -53396,7 +53774,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000706 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -53422,7 +53800,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=551 + neuronames:551 BIRNLEX:827 @@ -53502,6 +53880,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain. + Nerve primarily composed of special somatic afferent fibers innervating the inner ear, and is involved in balance, position, and hearing.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] 8n @@ -53529,7 +53908,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Vestibulocochlear_nerve XAO:0003095 ZFA:0000247 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=553 + neuronames:553 CN-VIII VIII nerve VIIIth cranial nerve @@ -53552,6 +53931,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An octaval nerve statoacoustic nerve UBERON:0001648 + @@ -53592,7 +53972,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000695 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -53624,7 +54004,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=553 + neuronames:553 BIRNLEX:890 @@ -53675,6 +54055,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult). + Small nerve consisting of branchiomotor and visceral efferent and afferent fibers which innervate the m. subarculais rectus I, dorsal buccal mucosa, and the tongue.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] 9n @@ -53702,7 +54083,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Glossopharyngeal_nerve XAO:0003096 ZFA:0000668 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=701 + neuronames:701 glossopharyngeal IX glossopharyngeal IX nerve glossopharyngeal nerve [IX] @@ -53716,6 +54097,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nerve IX nervus glossopharyngeus UBERON:0001649 + @@ -53745,7 +54127,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000701 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -53777,7 +54159,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=701 + neuronames:701 BIRNLEX:899 @@ -53828,6 +54210,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that innervates the muscles of the tongue. + Cranial nerve that innervates muscles in the tongue. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-14, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] In amphibians, represents the hypoglossal nerve in amniotes. Innverates mm. geniohyoideus, genioglossus, hyoglossus, rectus cervicis Nerve which innervates the muscles associated with the tongue including mm geniohyoideus, genioglossus, hyoglossus and rectus cervicis.[AAO] @@ -53856,7 +54239,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000693 Wikipedia:Hypoglossal_nerve XAO:0004215 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=704 + neuronames:704 cranial nerve XII hypoglossal XII hypoglossal XII nerve @@ -53871,6 +54254,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervi hypoglossalis nervus hypoglossus UBERON:0001650 + hypoglossal nerve @@ -53941,7 +54325,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=704 + neuronames:704 BIRNLEX:820 @@ -54003,7 +54387,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - @@ -54012,6 +54395,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO] MA and NCITA also has 'anterior facial vein' AAO:0010513 @@ -54029,6 +54413,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior facial vein vena facialis anterior UBERON:0001653 + facial vein http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png @@ -54263,7 +54648,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0000427 XAO:0000428 ZFA:0000295 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1402 + neuronames:1402 5th ganglion Gasserian ganglion fifth ganglion @@ -54949,7 +55334,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An infraorbital 1 - TODO:TODO VHOG:0001149 ZFA:0000223 @@ -57060,7 +57444,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000707 Wikipedia:Geniculate_ganglion ZFA:0001291 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1535 + neuronames:1535 facial VII ganglion gVII ganglion genicularum @@ -57133,7 +57517,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000707 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -57258,7 +57642,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000702 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -57549,7 +57933,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:54375 GAID:115 MA:0000285 - MESH:A02.165.639 + MESH:D009300 NCIT:C33160 OpenCyc:Mx4rv7e-k5wpEbGdrcN5Y29ycA SCTID:181197004 @@ -57598,7 +57982,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -58057,7 +58441,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000454 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -58177,7 +58561,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000453 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -58238,7 +58622,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An eyelid - Eye:makeup.jpg + https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg @@ -58312,7 +58696,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An upper eyelid - Eye:makeup.jpg + https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg @@ -58365,7 +58749,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lower eyelid - Eye:makeup.jpg + https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg @@ -58530,6 +58914,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9030 MA:0001073 MBA:35 + MESH:D065838 NCIT:C12897 SCTID:362457000 TAO:0000553 @@ -58538,7 +58923,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Nucleus_of_oculomotor_nerve XAO:0004389 ZFA:0000553 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=492 + neuronames:492 OM nucleus nervi oculomotorii nucleus of oculomotor nerve @@ -58665,7 +59050,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=492 + neuronames:492 BIRNLEX:1240 @@ -58907,7 +59292,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001354 Wikipedia:Mesencephalic_nucleus_of_trigeminal_nerve ZFA:0000312 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=558 + neuronames:558 mesencephalic trigeminal V nucleus mesencephalic trigeminal nucleus nucleus of mesencephalic root of v @@ -58988,7 +59373,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=558 + neuronames:558 BIRNLEX:1010 @@ -59428,7 +59813,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:54825 GAID:815 MA:0001591 - MESH:A08.800.550.700.120.800 + MESH:D013650 NCIT:C96518 OpenCyc:Mx4rvVjan5wpEbGdrcN5Y29ycA SCTID:362099006 @@ -59512,7 +59897,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000130 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -59600,7 +59985,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:339 MA:0000443 MAT:0000447 - MESH:A03.867.557 + MESH:D009305 NCIT:C12423 OpenCyc:Mx4rwUPoDJwpEbGdrcN5Y29ycA SCTID:181200003 @@ -59617,7 +60002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nasopharynx - Illu:pharynx.jpg + https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg @@ -59700,7 +60085,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:340 MA:0000351 MAT:0000446 - MESH:A03.867.603 + MESH:D009960 NCIT:C12762 OpenCyc:Mx4rwACoxpwpEbGdrcN5Y29ycA SCTID:263376008 @@ -59718,7 +60103,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An oropharynx - Illu:pharynx.jpg + https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg @@ -59781,7 +60166,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:54970 GAID:1288 MA:0000774 - MESH:A15.382.520.604.084 + MESH:D000234 NCIT:C33318 SCTID:181199001 UMLS:C0001428 @@ -59877,7 +60262,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An soft palate - Tonsils:diagram.jpg + https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg @@ -59988,7 +60373,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An seeAlso - bifid uvula and cleft palate palatine uvula - Tonsils:diagram.jpg + https://upload.wikimedia.org/wikipedia/commons/8/81/Tonsils_diagram.jpg @@ -60315,7 +60700,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:55099 GAID:112 MA:0001764 - MESH:A02.165.507.870 + MESH:D013957 NCIT:C33780 SCTID:263483000 UMLS:C0040126 @@ -60438,7 +60823,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:55108 GAID:107 MA:0001758 - MESH:A02.165.507 + MESH:D007817 NCIT:C12281 SCTID:263482005 UMLS:C0023050 @@ -60513,7 +60898,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:55109 GAID:109 MA:0001759 - MESH:A02.165.507.083 + MESH:D001193 NCIT:C32148 SCTID:264446005 UMLS:C0003943 @@ -60807,7 +61192,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -60882,7 +61267,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:55628 GAID:1272 MA:0002542 - MESH:A14.254.900.280 + MESH:D003804 NCIT:C32453 SCTID:362112004 TAO:0005143 @@ -60997,7 +61382,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35303 FMA:55629 MA:0002543 - MESH:A14.254.900.255 + MESH:D003743 NCIT:C32505 SCTID:362113009 UMLS:C0011350 @@ -61095,7 +61480,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35203 FMA:55630 MA:0002541 - MESH:A14.254.646.267 + MESH:D003739 NCIT:C32276 SCTID:362114003 UMLS:C0011343 @@ -61111,7 +61496,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001753 cementum - The:Periodontium.jpg + https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg @@ -61190,7 +61575,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:55631 GAID:1270 MA:0001599 - MESH:A14.254.900.260 + MESH:D003782 NCIT:C32451 SCTID:362110007 TAO:0005141 @@ -61207,7 +61592,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An dental pulp - Tooth:Section.svg + https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg @@ -61337,7 +61722,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000312 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417 http://bgee.unil.ch/ @@ -61483,7 +61868,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0001021 CALOHA:TS-2380 GAID:216 - MESH:A14.254.646 + MESH:D010519 NCIT:C33304 UMLS:C0031093 Wikipedia:Periodontium @@ -61495,7 +61880,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0001758 periodontium - The:Periodontium.jpg + https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg @@ -61572,6 +61957,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart). + Nerve consisting of branchiomotor and visceral efferent fibers which branch and innervate the smooth muscles and glands of the heart, lungs, esophagus, and stomach as well as some throat muscles. Sensory fibers supply mucosa of the mouth and pharynx.[AAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG] 10n @@ -61599,7 +61985,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0003097 ZFA:0000453 galen:VagusNerve - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 + neuronames:702 nervus vagus [x] tenth cranial nerve vagus @@ -61616,6 +62002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vagus nerve or its root UBERON:0001759 + @@ -61645,7 +62032,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000737 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 http://bgee.unil.ch/ @@ -61683,7 +62070,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 + neuronames:702 BIRNLEX:801 @@ -61756,7 +62143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An frontal sinus - Nnh:front.svg + https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg @@ -61979,7 +62366,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:57662 GAID:1277 MA:0001598 - MESH:A14.254.900.720.250 + MESH:D003771 TAO:0005140 VHOG:0001465 VSAO:0000025 @@ -62492,7 +62879,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -62564,6 +62951,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. + The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] iridial @@ -62593,6 +62981,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An irises UBERON:0001769 + @@ -62691,7 +63080,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pupil - Eye:iris.jpg + https://upload.wikimedia.org/wikipedia/commons/6/65/Eye_iris.jpg @@ -62747,12 +63136,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - @@ -62760,6 +63143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The smooth stratified squamous epithelium that covers the outer surface of the cornea. + Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO] In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals @@ -62796,6 +63180,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epithelium posterius corneae UBERON:0001772 + @@ -62811,7 +63196,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -62973,7 +63358,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -63116,6 +63501,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] AAO:0010341 BTO:0000260 @@ -63132,13 +63518,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000102 Wikipedia:Ciliary_body XAO:0000186 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1571 + neuronames:1571 ocular ciliary body uberon anterior uvea ciliary bodies corpus ciliare UBERON:0001775 + @@ -63154,7 +63541,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -63221,6 +63608,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA + choroidal MP treats posterior uvea and optic choroid as distinct BTO:0001829 @@ -63248,6 +63636,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An choroidea optic choroid UBERON:0001776 + @@ -63392,7 +63781,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cjm - ISBN:0781772214 + ISBN:0781772214 Wikipedia @@ -63463,6 +63852,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A double layer covering the ciliary body that produces aqueous humor. + BTO:0001770 CALOHA:TS-0695 EMAPA:35239 @@ -63477,6 +63867,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ocular ciliary epithelium uberon UBERON:0001778 + ciliary epithelium @@ -63566,6 +63957,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. + Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG] AAO:0011101 BAMS:spin @@ -63583,7 +63975,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000824 Wikipedia:Spinal_nerve XAO:0003101 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1228 + neuronames:1228 backbone nerve nerve of backbone nerve of spinal column @@ -63597,10 +63989,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervi spinales spinal nerves UBERON:0001780 + spinal nerve - Spinal:nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -63766,6 +64159,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]. + A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO] The monolayer of pigmented epithelium covering the neural retina.[AAO] (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] @@ -63784,7 +64178,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000144 UMLS:C0035322 VHOG:0000536 - Wikipedia:Retinal_pigment_epithelium + Wikipedia:Retinal_pigment_epithelium XAO:0003217 ZFA:0000144 outer pigmented layer of retina @@ -63805,6 +64199,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An retinal pigment layer stratum pigmentosa retinae UBERON:0001782 + @@ -63815,7 +64210,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP]. - Wikipedia:Retinal_pigment_epithelium + Wikipedia:Retinal_pigment_epithelium ZFIN:curator @@ -63857,7 +64252,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An retinal pigment epithelium MP:0005201 - Wikipedia:Retinal_pigment_epithelium + Wikipedia:Retinal_pigment_epithelium @@ -63883,7 +64278,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An p. pigmentosa retinae - Wikipedia:Retinal_pigment_epithelium + Wikipedia:Retinal_pigment_epithelium @@ -63896,7 +64291,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stratum pigmentosa retinae - Wikipedia:Retinal_pigment_epithelium + Wikipedia:Retinal_pigment_epithelium @@ -64028,6 +64423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN. + Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO] We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG] See https://github.com/obophenotype/mouse-anatomy-ontology/issues/6 @@ -64054,12 +64450,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0000429 XAO:0003089 ZFA:0000641 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1227 + neuronames:1227 cranial neural tree organ uberon cranial nerves nervus cranialis UBERON:0001785 + @@ -64436,6 +64833,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The layer within the retina where the photoreceptor cell bodies reside. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] outer nuclear layer BAMS:Ronl @@ -64463,6 +64861,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An retina, outer nuclear layer retinal outer nuclear layers UBERON:0001789 + outer nuclear layer of retina @@ -64656,6 +65055,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia). + The layer of the retina composed of the cell bodies of bipolar cells, horizontal cells, and some of the cell bodies of amacrine cells[BTO:0003176]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] BAMS:Rinl @@ -64685,6 +65085,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An layer of inner granules retina, inner nuclear layer UBERON:0001791 + AO notes NLXANAT:1005031 appears to be retired @@ -64764,6 +65165,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer. + a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030] @@ -64795,6 +65197,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An retina, ganglion cell layer stratum ganglionicum retinae UBERON:0001792 + @@ -65286,7 +65689,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA def states A and P located_in in EHDAA2 - VHOG + VHOG @@ -65300,7 +65703,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG http://bgee.unil.ch/ http://medical-dictionary.thefreedictionary.com/aqueous+humour @@ -65310,7 +65713,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 http://bgee.unil.ch/ @@ -65361,7 +65764,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:58827 GAID:919 MA:0002462 - MESH:A09.371.943 + MESH:D014822 NCIT:C33884 SCTID:181170006 UMLS:C0042905 @@ -65595,7 +65998,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -65706,6 +66109,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A layer of epithelial cells that is part of the eye. this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former + BTO:0001873 CALOHA:TS-0543 EMAPA:32871 @@ -65726,6 +66130,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lens epithelium uberon UBERON:0001803 + epithelium of lens @@ -65789,12 +66194,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - @@ -65988,6 +66387,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17157 FMA:5890 MA:0000226 + MESH:D005728 NCIT:C12467 SCTID:362485003 UMLS:C0017071 @@ -66188,6 +66588,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32813 FMA:5894 MA:0002469 + MESH:D005726 NCIT:C52557 NLXANAT:100303 SCTID:279284004 @@ -66282,9 +66683,16 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + + + + + + + Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]. - in FMA this is a subtype of junction rather than tissue + + Made to be a subtype of junction rather than tissue to be consistent with FMA plexus AEO:0000138 BTO:0000205 @@ -66299,6 +66707,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Nervous_system_plexus uberon UBERON:0001810 + nerve plexus @@ -66308,11 +66717,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA]. FMA:5901 Wikipedia:Nervous_system_plexus + https://github.com/obophenotype/cell-ontology/issues/1306 - in FMA this is a subtype of junction rather than tissue + Made to be a subtype of junction rather than tissue to be consistent with FMA FMA @@ -66364,7 +66774,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:59011 GAID:898 MA:0000265 - MESH:A09.371.192 + MESH:D003228 NCIT:C12341 SCTID:181161008 UMLS:C0009758 @@ -66419,7 +66829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -66615,6 +67025,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified]. check superclass - nerve vs collection of fibers vs junction; note that FMA also has 'brachial autonomic nerve plexus' + A nerve plexus originating from the anterior branches of the last four cervical and the first thoracic spinal nerves, giving off many of the principal nerves of the shoulder, chest, and arms. [TFD][VHOG] To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG] EHDAA2:0000180 @@ -66634,6 +67045,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon plexus brachialis UBERON:0001814 + brachial nerve plexus http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png @@ -66912,7 +67324,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glandula praeorbitalis - NCBITaxon:91561 + NCBITaxon:91561 Wikipedia:Preorbital_gland @@ -66920,7 +67332,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An preorbital gland - NCBITaxon:91561 + NCBITaxon:91561 Wikipedia:Preorbital_gland @@ -67183,6 +67595,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP]. sebaceous glands are also found in glabrous areas of eyelids, nose, penis, labia minora and nipples, and do not always secrete into hair follices. This causes some confusion in classification. In addition some structures, such as preputial glands are sometimes called 'modified' sebaceous glands, implying a non-subclass relationship. we follow MP and MA in keeping this class generic and creating a distinct subclass for sebaceuous glands of the skin. The FMA class may be better placed under this subclass. + Any of the numerous holocrine glands in the dermis that empty into a hair follicle and produce and secrete sebum. [TFD][VHOG] Sebaceous glands are also limited to mammals.[well established][VHOG] BTO:0001980 @@ -67203,6 +67616,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glandula sebaceae sebaceous follicle UBERON:0001821 + @@ -67299,6 +67713,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37681 FMA:59502 MA:0001883 + MESH:D055171 NCIT:C49593 SCTID:278941001 UMLS:C0225415 @@ -67469,7 +67884,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An paranasal sinus - Nnh:front.svg + https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg @@ -67580,7 +67995,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:59762 GAID:1257 MA:0000342 - MESH:A14.254.646.480 + MESH:D005881 NCIT:C32677 OpenCyc:Mx4rvViWnZwpEbGdrcN5Y29ycA SCTID:181224006 @@ -67598,7 +68013,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gingiva - Tooth:Section.svg + https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg @@ -67973,7 +68388,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO FMA-implicit - VHOG + VHOG ZFA @@ -68745,7 +69160,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA - VHOG + VHOG XAO ncit @@ -68763,7 +69178,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A spiral-shaped cavity in the petrous portion of the temporal bone of the inner ear, containing the nerve endings essential for hearing and forming one of the divisions of the labyrinth. [TFD][VHOG] 2012-09-17 VHOG:0000691 - VHOG + VHOG http://bgee.unil.ch/ http://medical-dictionary.thefreedictionary.com/cochlea @@ -68773,7 +69188,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Because achieving high sensitivity is generally advantageous for auditory organs, it is not surprising that evidence for cochlear amplification is also seen in nonmammals. Spontaneous otoacoustic emissions (SOAEs) are narrow-band sound signals emitted from the inner ear, and it is generally assumed that their energy derives from the hair-cell molecular motors underlying cochlear amplification. However, all terrestrial vertebrates studied so far (including amphibians) show very similar SOAEs. The most parsimonious explanation for the universality of this phenomena is that some kind of amplifying mechanism is at least as old as land vertebrates themselves.[well established][VHOG] 2012-09-17 VHOG:0000691 - VHOG + VHOG DOI:10.1016/S0959-4388(98)80033-0 Manley GA, Koeppl C, Phylogenetic development of the cochlea and its innervation. Current Opinion in Neurobiology (1998) http://bgee.unil.ch/ @@ -68839,7 +69254,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:60908 GAID:1185 MA:0002529 - MESH:A12.207.571.678 + MESH:D010498 NCIT:C33297 TAO:0005413 UMLS:C0031059 @@ -69347,7 +69762,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:61112 GAID:1184 MA:0002528 - MESH:A12.207.571.324 + MESH:D004710 NCIT:C32513 TAO:0005414 UMLS:C0014166 @@ -69771,6 +70186,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32830 FMA:61122 MA:0000251 + MESH:D054776 NCIT:C33528 SCTID:279833009 UMLS:C1323109 @@ -69934,6 +70350,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17815 FMA:61255 MA:0000245 + MESH:D014722 NCIT:C33871 SCTID:181188003 UMLS:C0042606 @@ -69989,6 +70406,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35753 FMA:61269 MA:0001206 + MESH:D054738 SCTID:362578000 Wikipedia:Scala_vestibuli uberon @@ -70094,7 +70512,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:61339 GAID:103 MA:0001886 - MESH:A02.165.207 + MESH:D004425 NCIT:C49225 UMLS:C0013445 external ear cartilage @@ -70159,7 +70577,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001639 Wikipedia:Cerebral_hemisphere galen:CerebralHemisphere - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241 + neuronames:241 uberon cerebrum hemisphere @@ -70216,7 +70634,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241 + neuronames:241 BIRNLEX:1042 @@ -70347,6 +70765,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Lower lateral part of the cerebral hemisphere. (MSH). + BAMS:TL BAMS:Temporal_lobe BIRNLEX:1160 @@ -70360,19 +70779,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:635 HBA:4132 MAT:0000508 - MESH:A08.186.211.730.885.213.863 + MESH:D013702 NCIT:C12353 OpenCyc:Mx4rwQLi-ZwpEbGdrcN5Y29ycA SCTID:180921000 UMLS:C0039485 UMLS:C1268978 Wikipedia:Temporal_lobe - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=125 + neuronames:125 lobus temporalis temporal cortex uberon UBERON:0001871 + Boundary notes: It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. [Wikipedia:Temporal_lobe] @@ -70412,7 +70832,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=125 + neuronames:125 BIRNLEX:1160 @@ -70430,6 +70850,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Upper central part of the cerebral hemisphere. (MSH). + parietal region BAMS:Parietal_lobe BIRNLEX:1148 @@ -70442,18 +70863,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:680 HBA:4084 MAT:0000506 - MESH:A08.186.211.730.885.213.670 + MESH:D010296 NCIT:C12354 OpenCyc:Mx4rvg-typwpEbGdrcN5Y29ycA SCTID:180922007 UMLS:C0030560 Wikipedia:Parietal_lobe - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=95 + neuronames:95 regio parietalis uberon lobus parietalis UBERON:0001872 + parietal lobe @@ -70486,7 +70908,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=95 + neuronames:95 BIRNLEX:1148 @@ -70537,14 +70959,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4278 MA:0000894 MAT:0000513 - MESH:A08.186.211.730.885.105.487.550.184 + MESH:D002421 NCIT:C12451 OpenCyc:Mx4rvvyAjJwpEbGdrcN5Y29ycA PBA:10082 SCTID:279297002 UMLS:C0007461 Wikipedia:Caudate_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=226 + neuronames:226 caudatus uberon Ammon horn fields @@ -70595,7 +71017,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=226 + neuronames:226 BIRNLEX:1373 @@ -70644,6 +71066,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion. check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM) + Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]. All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG] BAMS:PU @@ -70659,17 +71082,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:671 HBA:4287 MA:0000895 - MESH:A08.186.211.730.885.105.487.550.784 + MESH:D011699 NCIT:C12452 PBA:10086 SCTID:281512002 UMLS:C0034169 VHOG:0001456 Wikipedia:Putamen - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=230 + neuronames:230 nucleus putamen uberon UBERON:0001874 + putamen @@ -70717,7 +71141,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=230 + neuronames:230 BIRNLEX:809 @@ -70755,13 +71179,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4293 MA:0000890 MAT:0000510 - MESH:A08.186.211.730.885.105.487.397 + MESH:D005917 NCIT:C12449 PBA:10097 SCTID:362361005 UMLS:C0017651 Wikipedia:Globus_pallidus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=231 + neuronames:231 pale body paleostriatum uberon @@ -70775,7 +71199,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO and MA are inconsistent w.r.t striatum and pallidum being non-overlapping as in ABA. Note that we have pallidum as part_of basal gangion, so we can make the direct link to basal ganglion. ISBN:1588900649 says: ... a derivative of the diencephalon, seperates as a result of growing fibers of theinternal capsule and is finally displaced into telencephalon. only a small medial remnannt remains, the entopeduncular nucleus. The globus pallidus should be regarded as part of the subthalamus globus pallidus - Brain:structure.gif + https://upload.wikimedia.org/wikipedia/commons/e/ee/Brain_structure.gif @@ -70815,7 +71239,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=231 + neuronames:231 BIRNLEX:1234 @@ -70902,7 +71326,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4327 MA:0000887 MAT:0000289 - MESH:A08.186.211.577.090 + MESH:D000679 MIAA:0000289 NCIT:C12440 OpenCyc:Mx4rwJC_2ZwpEbGdrcN5Y29ycA @@ -70911,7 +71335,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0002708 VHOG:0001277 Wikipedia:Amygdala - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=237 + neuronames:237 amygdaloid body amygdaloid complex amygdaloid nuclear complex @@ -71002,7 +71426,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=237 + neuronames:237 BIRNLEX:1241 @@ -71077,11 +71501,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:265504792 MA:0000977 MBA:481 - MESH:A08.186.211.577.699.400 + MESH:D020670 PBA:10095 UMLS:C0262264 Wikipedia:Islands_of_Calleja - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=276 + neuronames:276 Calleja island islands of Calleja uberon @@ -71116,7 +71540,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=276 + neuronames:276 BIRNLEX:1113 @@ -71185,13 +71609,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000892 MAT:0000512 MBA:56 - MESH:A08.186.211.730.885.105.683 + MESH:D009714 NCIT:C52733 PBA:10092 SCTID:427667007 UMLS:C0028633 Wikipedia:Nucleus_accumbens - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=277 + neuronames:277 accumbens nucleus colliculus of caudate nucleus nucleus accumbens septi @@ -71260,7 +71684,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=277 + neuronames:277 BIRNLEX:727 @@ -71320,6 +71744,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:10145 MA:0000976 MBA:754 + MESH:D066208 NLXANAT:1005037 PBA:10096 VHOG:0001625 @@ -71343,7 +71768,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2-inferred MA - VHOG + VHOG Wikipedia @@ -71392,6 +71817,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. + A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG] BAMS:phn BTO:0001063 @@ -71412,6 +71838,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nervus phrenicus phrenic UBERON:0001884 + phrenic nerve @@ -71497,12 +71924,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12891 MA:0000190 MBA:726 - MESH:A08.186.211.577.405.200 + MESH:D018891 NCIT:C32452 SCTID:279211002 UMLS:C0152314 Wikipedia:Dentate_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=179 + neuronames:179 area dentata dentate area (dentate gyrus) dentate gyrus @@ -71639,7 +72066,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001377 Wikipedia:Choroid_plexus ZFA:0001443 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1377 + neuronames:1377 chorioid plexus plexus choroideus uberon @@ -71680,7 +72107,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CP - PMID:23375746 + PMID:23375746 @@ -71811,6 +72238,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The most anterior region of the brain including both the telencephalon and diencephalon. + Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO] The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO] relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO] @@ -71842,11 +72270,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Forebrain XAO:0000011 ZFA:0000109 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 + neuronames:27 uberon prosencephalon UBERON:0001890 + @@ -71930,7 +72359,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 + neuronames:27 BIRNLEX:1509 @@ -71951,6 +72380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An developmental relationships need revised + Middle part of the brain composed of the optic tectum and penducular region.[AAO] The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] @@ -71987,11 +72417,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Midbrain XAO:0000014 ZFA:0000128 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 + neuronames:462 uberon mesencephalon UBERON:0001891 + @@ -72022,7 +72453,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA https://github.com/obophenotype/uberon/issues/378 ABA - pending + pending @@ -72030,7 +72461,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA ABA - pending + pending @@ -72057,7 +72488,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000069 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -72089,7 +72520,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 + neuronames:462 BIRNLEX:1667 @@ -72270,7 +72701,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Telencephalon XAO:0000012 ZFA:0000079 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 + neuronames:31 cerebrum endbrain uberon @@ -72351,37 +72782,37 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In mammals the cortex covers almost the whole of the cerebral hemispheres. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight. - Wikipedia:Telencephalon#Variation_among_species + Wikipedia:Telencephalon#Variation_among_species @@ -72398,7 +72829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 + neuronames:31 BIRNLEX:1115 @@ -72416,7 +72847,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An endbrain Swanson:2004 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 + neuronames:31 @@ -72473,7 +72904,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000171 MAT:0000420 MBA:1129 - MESH:A08.186.211.730.385 + MESH:D004027 MIAA:0000420 NCIT:C12456 OpenCyc:Mx4rwC-V0JwpEbGdrcN5Y29ycA @@ -72485,7 +72916,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Diencephalon XAO:0000013 ZFA:0000101 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288 + neuronames:288 between brain interbrain mature diencephalon @@ -72525,7 +72956,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA ABA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -72565,7 +72996,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000318 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -72597,7 +73028,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288 + neuronames:288 BIRNLEX:1503 @@ -72668,7 +73099,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1516904 VHOG:0000741 Wikipedia:Metencephalon - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543 + neuronames:543 epencephalon-2 uberon UBERON:0001895 @@ -72744,7 +73175,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543 + neuronames:543 BIRNLEX:965 @@ -72775,6 +73206,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] @@ -72812,13 +73244,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Bone_marrow_of_ovary_oblongata XAO:0003100 ZFA:0000545 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 + neuronames:698 bulbus uberon medulla oblonzata metepencephalon UBERON:0001896 + @@ -72888,7 +73321,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 + neuronames:698 BIRNLEX:957 @@ -72949,7 +73382,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000179 MAT:0000109 MBA:549 - MESH:A08.186.211.730.385.826 MIAA:0000109 NCIT:C12459 OpenCyc:Mx4rwMPQ65wpEbGdrcN5Y29ycA @@ -72961,7 +73393,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Thalamus ZFA:0001215 galen:Thalamus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=300 + neuronames:300 wider thalamus uberon thalamencephalon @@ -73022,7 +73454,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Th BIRNLEX:954 NIFSTD:NeuroNames_abbrevSource - PMID:23375746 + PMID:23375746 @@ -73047,7 +73479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=300 + neuronames:300 BIRNLEX:954 @@ -73101,6 +73533,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. Kimmel et al, 1995.[TAO] Part of the diencephalon ventral to the thalamus consisting of connecting fibers and is a center for control of the autonomous nervous system.[AAO] For instance, the vertebrate ventral diencephalon generates the hypothalamus which functions as a major endocrine center in cooperation with the hypophysis, the anterior part of the pituitary gland, located just ventral to the hypothalamus. In the amphioxus brain, the presence of a hypothalamus-like structure has been reported associated with the ventrally located Hatschek's pit, the hypothetical hypophysial homologue. It is thus conceivable that a hypothalamus-like structure originally involved in endocrine functions may have already been present before the establishment of vertebrates.[well established][VHOG] @@ -73126,7 +73559,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000173 MAT:0000112 MBA:1097 - MESH:A08.186.211.577.482 + MESH:D007031 MIAA:0000112 NCIT:C12458 OpenCyc:Mx4rwEgr9JwpEbGdrcN5Y29ycA @@ -73138,13 +73571,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0004070 ZFA:0000032 galen:Hypothalamus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 + neuronames:292 preoptico-hypothalamic area preoptico-hypothalamic region uberon hypothalamus UBERON:0001898 + @@ -73246,7 +73680,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 + neuronames:292 BIRNLEX:734 @@ -73274,6 +73708,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + Dorsal segment of the diencephalon containing the habenular ganglia, a choroid plexus, and the pineal organ.[AAO] The roof of the diencephalon lying above the thalamus. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-11, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] The epithalamus has been historically conceived as a distinct neuroanatomical moiety within the diencephalon of all vertebrates. (...) The evolutionary origins of epithalamic structures are uncertain but asymmetry in this region is likely to have existed at the origin of the vertebrate, perhaps even the chordate, lineage.[well established][VHOG] @@ -73300,7 +73735,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000172 MAT:0000422 MBA:958 - MESH:A08.186.211.577.200 + MESH:D019261 MIAA:0000422 NCIT:C12457 OpenCyc:Mx4rvneLQpwpEbGdrcN5Y29ycA @@ -73311,11 +73746,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000178 Wikipedia:Epithalamus ZFA:0000509 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 + neuronames:292 uberon epithalamus UBERON:0001899 + @@ -73397,7 +73833,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292 + neuronames:292 BIRNLEX:1710 @@ -73423,6 +73859,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anterior part of the diencephalon that lies between the dorsal thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis[GO, modified]. + subthalamic SbTh BAMS:SbTh @@ -73441,14 +73878,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:653 HBA:4504 MA:0000181 - MESH:A08.186.211.730.385.800 + MESH:D020530 NCIT:C52731 SCTID:279332007 TAO:0000458 UMLS:C0152349 Wikipedia:Subthalamus ZFA:0000458 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=434 + neuronames:434 subthalamic region subthalamus thalamus ventralis @@ -73457,6 +73894,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An perithalamus prethalamus UBERON:0001900 + @@ -73498,7 +73936,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=434 + neuronames:434 BIRNLEX:708 @@ -73567,6 +74005,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The epithelial lining of the trachea which contains numerous ciliated cells. + UBERON:0003227 BTO:0001389 CALOHA:TS-1061 @@ -73589,6 +74028,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An windpipe epithelium uberon UBERON:0001901 + epithelium of trachea @@ -73670,13 +74110,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:619 HBA:4522 MA:0000830 - MESH:A08.186.211.577.200.360 + MESH:D019262 SCTID:362389008 TAO:0000213 UMLS:C0152362 Wikipedia:Habenula ZFA:0000213 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=294 + neuronames:294 habenula complex uberon ganglion intercrurale @@ -73733,7 +74173,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=294 + neuronames:294 BIRNLEX:1611 @@ -73796,6 +74236,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + A circumscribed swelling, includes the pineal primordium that appears late in the segmentation period in the dorsal midline of the diencephalon. Kimmel et al, 1995.[TAO] Anatomical structure which is a medial outgrowth of the thalamus on the dorsal surface of the brain. This structure is light sensitive and secretes melatonin when exposed to prolonged darkness.[AAO] relationship loss: part_of pineal complex (TAO:0001359)[TAO] @@ -73836,7 +74277,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An XAO:0000160 ZFA:0000019 galen:PinealGland - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=297 + neuronames:297 corpus pineale glandula pinealis pineal gland @@ -73851,6 +74292,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stirnorgan UBERON:0001905 + @@ -73959,7 +74401,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=297 + neuronames:297 BIRNLEX:1184 @@ -74067,13 +74509,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4518 MA:0000877 MBA:470 - MESH:A08.186.211.730.385.800.800 + MESH:D020531 NCIT:C12454 NLXANAT:1010002 SCTID:361575000 UMLS:C0152355 Wikipedia:Subthalamic_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=435 + neuronames:435 Luys' nucleus body of Forel body of Luys @@ -74213,6 +74655,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF]. relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with' + BAMS:opt BIRNLEX:1684 BM:Tel-OT @@ -74234,7 +74677,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Optic_tract XAO:0004101 ZFA:0000252 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=460 + neuronames:460 optic lemniscus uberon optic tracts @@ -74242,6 +74685,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tractus opticus visual pathway UBERON:0001908 + @@ -74271,7 +74715,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=460 + neuronames:460 BIRNLEX:1684 @@ -74338,9 +74782,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279335009 TAO:0000359 UMLS:C0152363 - Wikipedia:Habenular_commissure + Wikipedia:Habenular_commissure ZFA:0000359 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=299 + neuronames:299 commissura habenularum commissure habenularum uberon @@ -74380,13 +74824,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ZFA-modified + ZFA-modified A brain commissure that is situated in front of the pineal gland and connects the habenular nucleus on one side of the diencephalon with that on the other side. - Wikipedia:Habenular_commissure + Wikipedia:Habenular_commissure http://orcid.org/0000-0002-6601-2165 @@ -74412,14 +74856,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=299 + neuronames:299 BIRNLEX:1609 commissura habenularum - Wikipedia:Habenular_commissure + Wikipedia:Habenular_commissure @@ -74718,7 +75162,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1230 MA:0002552 MAT:0000056 - MESH:A13.622 + MESH:D008892 MIAA:0000056 NCIT:C13401 OpenCyc:Mx4rvVjGZJwpEbGdrcN5Y29ycA @@ -74803,7 +75247,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + @@ -74956,7 +75400,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:149 SCTID:369163000 UMLS:C0175253 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=308 + neuronames:308 nuclei paraventriculares thalami paraventricular gray paraventricular nuclei of thalamus @@ -74987,7 +75431,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The nucleus paraventricularis anterior thalami and nuclues paraventricularis posterior thalami, two of the nuclei mediani thalami; they are situated on the dorsomedial wall of the thalamus, juxtaposed to the third ventricle. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -75012,7 +75456,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=308 + neuronames:308 BIRNLEX:764 @@ -75087,7 +75531,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33260 SCTID:279150008 UMLS:C0228352 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=324 + neuronames:324 nuclei parafasciculares thalami nucleus parafascicularis nucleus parafascicularis (Hassler) @@ -75159,7 +75603,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=324 + neuronames:324 BIRNLEX:952 @@ -75232,7 +75676,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PBA:128012616 SCTID:279161000 UMLS:C0920328 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=321 + neuronames:321 central medial nucleus of thalamus central medial nucleus thalamus (rioch 1928) central medial thalamic nucleus @@ -75303,7 +75747,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=321 + neuronames:321 BIRNLEX:971 @@ -75372,7 +75816,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:907 SCTID:279152000 UMLS:C0228354 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=322 + neuronames:322 nucleus centralis lateralis superior (kusama) nucleus paracentral nucleus paracentral thalami @@ -75445,7 +75889,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=322 + neuronames:322 BIRNLEX:981 @@ -75526,7 +75970,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362377006 UMLS:C0086526 Wikipedia:Lateral_geniculate_body - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=352 + neuronames:352 corpus geniculatum laterales lateral geniculate complex lateral geniculate nucleus @@ -75598,7 +76042,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=352 + neuronames:352 BIRNLEX:1662 @@ -75699,7 +76143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362378001 UMLS:C0086596 Wikipedia:Medial_geniculate_body - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=355 + neuronames:355 corpus geniculatum mediale medial geniculate complex medial geniculate nuclei @@ -75776,7 +76220,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=355 + neuronames:355 BIRNLEX:1670 @@ -75861,14 +76305,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62313 GAID:644 HBA:4541 - MESH:A08.186.211.730.385.357.342.450 + MESH:D011301 SCTID:362382004 TAO:0000470 UMLS:C0033063 UMLS:C1284641 Wikipedia:Preoptic_area ZFA:0000470 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=377 + neuronames:377 preoptic nuclei preoptic region of hypothalamus uberon @@ -75915,7 +76359,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An POA - PMID:23375746 + PMID:23375746 @@ -75933,7 +76377,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=377 + neuronames:377 BIRNLEX:1706 @@ -76012,11 +76456,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12907 MA:0000849 MBA:390 - MESH:A08.186.211.730.385.357.342.650 + MESH:D013495 SCTID:369130007 UMLS:C0038869 Wikipedia:Supraoptic_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=385 + neuronames:385 nucleus supraopticus supra-optic nucleus supraoptic nucleus of hypothalamus @@ -76094,7 +76538,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=385 + neuronames:385 BIRNLEX:1411 @@ -76174,11 +76618,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12905 MA:0000848 MBA:38 - MESH:A08.186.211.730.385.357.342.400 + MESH:D010286 SCTID:369131006 UMLS:C0030532 Wikipedia:Paraventricular_nucleus_of_hypothalamus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=387 + neuronames:387 filiform nucleus paraventricular hypothalamic nucleus paraventricular nucleus @@ -76236,7 +76680,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=387 + neuronames:387 BIRNLEX:1407 @@ -76330,6 +76774,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] MTg tegmentum @@ -76351,7 +76796,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Midbrain_tegmentum XAO:0004271 ZFA:0000160 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 + neuronames:491 tegmentum mesencephali tegmentum of midbrain uberon @@ -76359,6 +76804,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tegmentum mesencephalicum UBERON:0001943 + @@ -76418,7 +76864,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 + neuronames:491 BIRNLEX:1200 @@ -76460,6 +76906,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + A narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light refle[MP:0009637]x Region of brain lying between the midbrain tectum and the thalamus (Sefton and Dreher, in Paxinos, G The rat central nervous system, 1995, pg 859), Situated at the level of poterior commissure and just rostral to the superior colliculus (Brodal, Neurological Anatomy, 3rd ed, 1981, pg 542) in monotremes, undifferentiated and possesses only a single nucleus[ISBN:0471888893] @@ -76479,6 +76926,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9079 MA:0001062 MBA:1100 + MESH:D066250 NLX:59721 SCTID:416333003 TAO:0000418 @@ -76487,7 +76935,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Pretectum XAO:0004303 ZFA:0000418 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=467 + neuronames:467 area pretectalis nuclei pretectales pretectal area @@ -76499,6 +76947,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An praetectum regio pretectalis UBERON:0001944 + @@ -76604,7 +77053,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=467 + neuronames:467 BIRNLEX:703 @@ -76673,6 +77122,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of the midbrain tecturm consisting of paired bodies that sit caudal to the thalamus and surround the pineal gland in the mesencephalon of vertebrate brains. It comprises the rostral aspect of the midbrain, posterior to the periaqueductal gray and adjacent superior the inferior colliculus. The inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin, quadruplet bodies). It consists of several identified cellular layers and also comprises the brachium of the superior colliculus and commissure of supeior colliculus from Wikipedia.org and Neuronames (MM). + The brain structure where the two separate inputs from the two eyes are combined into a single, integrated map.[AAO] The roof of the midbrain, morphologically visible by the end of the segmentation period. Kimmel et al, 1995.[TAO] The tectum is a layered structure, with a number of layers that vary by species. The superficial layers are sensory-related, and receive input from the eyes as well as other sensory systems.[1] The optic tectum is one of the fundamental components of the vertebrate brain, existing across the full range of species from hagfish to human.[4] (See the brain article for background.) Some aspects of the structure are very consistent, including a structure composed of a number of layers, with a dense input from the optic nerve to the superficial layers and another strong input conveying somatosensory input to deeper layers. Other aspects are highly variable, such as the total number of layers (from 3 in the African lungfish to 15 in the goldfish[5]), and the number of different types of cells (from 2 in the lungfish to 27 in the house sparrow[5] @@ -76691,13 +77141,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:576 HBA:9114 MA:0001068 - MESH:A08.186.211.132.659.237.816 + MESH:D013477 TAO:0000445 UMLS:C0228405 Wikipedia:Superior_colliculus XAO:0003226 ZFA:0000445 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=473 + neuronames:473 anterior colliculus anterior corpus quadrigeminum cranial colliculus @@ -76722,6 +77172,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tectum opticum UBERON:0001945 + @@ -76762,7 +77213,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=473 + neuronames:473 BIRNLEX:1040 @@ -76858,6 +77309,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of the midbrain tectum, consisting of paired predominantly gray matter elevations on the dorsal aspect of the midbrain, located caudal to the superior colliculus, dorsal to the periaqueductal gray of the cerebral aqueduct and rostral to the cerebellum. According to Neuronames, the inferior colliculus comprises the central, pericentral and external nucleus and two predominantly white matter structures, the brachium of the inferior colliculus and the commissure of the inferior colliculus (MM). + BAMS:IC BIRNLEX:806 DHBA:12305 @@ -76870,10 +77322,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9102 MA:0001067 MBA:4 - MESH:A08.186.211.132.659.237.364 + MESH:D007245 UMLS:C0228411 Wikipedia:Inferior_colliculus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=476 + neuronames:476 caudal colliculus inferior colliculi posterior colliculus @@ -76886,6 +77338,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An corpus quadrigeminum inferius UBERON:0001946 + inferior colliculus @@ -76906,7 +77359,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=476 + neuronames:476 BIRNLEX:806 @@ -76977,6 +77430,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + in animals without a significant corticospinal tract, gait is mainly controlled by the red nucleus. R BAMS:R @@ -76992,13 +77446,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9053 MA:0001063 MBA:214 - MESH:A08.186.211.132.659.822.642 + MESH:D012012 SCTID:279287006 TAO:0000552 UMLS:C0034910 Wikipedia:Red_nucleus ZFA:0000552 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=505 + neuronames:505 nucleus ruber uberon nucleus rotundus subthalamo-peduncularis @@ -77007,6 +77461,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nucleus ruber tegmenti (Stilling) red nucleus (Burdach) UBERON:0001947 + red nucleus @@ -77106,7 +77561,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=505 + neuronames:505 BIRNLEX:1478 @@ -77180,11 +77635,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:677 MA:0002754 MBA:315 - MESH:A08.186.211.730.885.213.420 + MESH:D019579 PBA:294021746 UMLS:C0175173 Wikipedia:Neocortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 + neuronames:757 cerebral neocortex homogenetic cortex homotypical cortex @@ -77231,7 +77686,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 + neuronames:757 BIRNLEX:2547 @@ -77334,7 +77789,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000191 MAT:0000114 MBA:375 - MESH:A08.186.211.577.405 + MESH:D006624 MIAA:0000114 NCIT:C12444 NCIT:C32374 @@ -77344,8 +77799,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0019564 VHOG:0001177 Wikipedia:Hippocampus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3157 http://scalablebrainatlas.incf.org/services/thumbnail.php?template=ABA07&size=L&dim=2d3d&format=png&region=CA + neuronames:3157 Ammon's horn ammon gyrus ammon horn @@ -77572,6 +78027,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies. + The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located. [Wikipedia:White_pulp] CALOHA:TS-1264 EMAPA:35809 @@ -77587,6 +78043,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon noduli lymphoidei splenici UBERON:0001959 + white pulp of spleen @@ -77637,6 +78094,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The area of the spleen in which T cells surround the central arteriole. + FMA distinguishes periarterial (PALS) from periarteriolar (FMA:62806) EMAPA:37750 FMA:62810 @@ -77649,6 +78107,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon splenic periarteriolar lymphoid sheath UBERON:0001960 + periarterial lymphatic sheath @@ -77704,6 +78163,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO]. todo - add part relationships to specific layers + FMA:62819 MA:0000140 NCIT:C12910 @@ -77718,6 +78178,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mucosal-associated lymphoid tissue uberon UBERON:0001961 + mucosa-associated lymphoid tissue @@ -77779,6 +78240,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO]. phylogenetic relationships to be added + guts of jawless fish contains cells with lymphocyte-like morphology (Mayer 2002). FMA:62820 MA:0000136 @@ -77789,6 +78251,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon GALT UBERON:0001962 + gut-associated lymphoid tissue @@ -77876,7 +78339,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C97341 UMLS:C0175412 Wikipedia:Substantia_nigra_pars_compacta - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 + neuronames:537 SNpc compact part of substantia nigra pars compacta @@ -77935,7 +78398,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 + neuronames:537 BIRNLEX:990 @@ -78024,7 +78487,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:381 UMLS:C0175413 Wikipedia:Pars_reticulata - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 + neuronames:537 nucleus substantiae nigrae, pars reticularis pars reticularis pars reticularis substantiae nigrae @@ -78135,7 +78598,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=537 + neuronames:537 BIRNLEX:968 @@ -78536,13 +78999,15 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. + Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO] BTO:0002626 EMAPA:35917 FMA:63130 MA:0000071 - MESH:A07.231.432.952 + MESH:D014699 NCIT:C12818 SCTID:341687009 TAO:0005315 @@ -78553,11 +79018,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon venula UBERON:0001979 + venule - Illu:capillary.jpg + https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg @@ -78595,6 +79061,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO] Small, terminal branch of an artery which generally connects to capillaries.[AAO] @@ -78618,7 +79085,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteriole - Illu:capillary.jpg + https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg @@ -78823,10 +79290,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - + Any of the smallest blood vessels connecting arterioles with venules. not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element + Any of the tiny blood vessels connecting the arterioles to the venules.[AAO] The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] capillaries lack tunica media and tunica adventitia; only the endothelial wall of the tunica intima belongs @@ -78838,7 +79305,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100035 FMA:63194 MA:0000065 - MESH:A07.231.432.410 + MESH:D002196 NCIT:C12685 NLXANAT:090902 OpenCyc:Mx4rvWEU-5wpEbGdrcN5Y29ycA @@ -78853,26 +79320,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001982 + capillary + https://github.com/obophenotype/uberon/issues/2186 http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg - - - - - FMA - MA - XAO - - - - - - ZFA - @@ -79082,6 +79537,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + CALOHA:TS-0172 EMAPA:35935 FMA:63882 @@ -79099,6 +79555,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon epithelium posterius corneae UBERON:0001985 + @@ -79145,6 +79602,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + endothelial BTO:0000393 CALOHA:TS-0278 @@ -79159,6 +79617,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001986 + The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) endothelium @@ -79224,6 +79683,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. + Phylogenetic analyses of the concatenated data set using maximum parsimony, maximum likelihood and distance based (neighbour joining) methods all converged on a nearly identical, well supported topology defining four principal eutherian lineages. The results affirm monophyly of traditional placental orders (except Artiodactyla and Insectivora), and also support some previously proposed, as well as new, superordinal clades.[well established][VHOG] placental Eutherians: In eutherians, the chorioallantoic membrane of the fetus establishes intimate contact with the adjacent vascular wall of the mother's uterus to produce the placenta, a composite structure formed in part from tissues of the fetus and in part from tissues of the mother [ISBN:0073040584 (Vertebrates, Kardong)]. TODO - is taxon restriction too strict, even if we restrict def to allantoic placenta? - WP says: also found in some snakes and lizards with varying levels of development up to mammalian levels. Pough et al. 1992. Herpetology: Third Edition. Pearson Prentice Hall:Pearson Education, Inc., 2002. // See also: DOI:10.1002/jmor.11011 @@ -79236,7 +79696,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:379 MA:0000386 MAT:0000279 - MESH:A16.759 + MESH:D010920 MIAA:0000279 NCIT:C13272 OpenCyc:Mx4rvv4zZ5wpEbGdrcN5Y29ycA @@ -79249,6 +79709,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0001987 + @@ -79937,6 +80398,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fibrocartilaginous FMA:64784 MA:0000108 + MESH:D051445 NCIT:C32599 SCTID:91685003 UMLS:C0684077 @@ -80171,7 +80633,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000985 Wikipedia:Olfactory_epithelium ZFA:0000554 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1900 + neuronames:1900 main olfactory epithelium nasal cavity olfactory epithelium olfactory membrane @@ -80240,7 +80702,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1900 + neuronames:1900 BIRNLEX:2703 @@ -80612,6 +81074,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Peripheral portion of the lymph node, underneath the capsule[WP]. + EMAPA:35525 FMA:66253 MA:0000740 @@ -80622,6 +81085,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon cortex nodi lymphoidei UBERON:0002006 + cortex of lymph node @@ -80660,6 +81124,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells. + EMAPA:35529 FMA:66254 MA:0000745 @@ -80667,6 +81132,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon medulla nodi lymphoidei UBERON:0002007 + medulla of lymph node @@ -80719,6 +81185,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. + Major artery which supplies blood to the lungs.[AAO] One of two arteries, leaving from the heart, the left one supplying the left lung and the right one supplying the right lung. [TFD][VHOG] On the other hand, in the sister clade of the actinopterygians, the sarcopterygians, the gill circulation is supplemented with lung ventilation. As a result, the pulmonary artery and vein and a functional ductus arteriosus arose as a major evolutionary innovation from the sixth arch, giving the organism a flexible shunt to balance blood supply to and from gills and lungs according to environmental conditions.[well established][VHOG] @@ -80750,10 +81217,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An truncus pulmonalis UBERON:0002012 + pulmonary artery - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -80822,7 +81290,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000982 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -80872,6 +81340,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage. + provides some protection from trauma and damage. The renal capsule relates to the other layers in the following order (moving from innermost to outermost): renal medulla renal cortex renal capsule perinephric fat (or 'perirenal fat') renal fascia paranephric fat (or 'pararenal fat') peritoneum (anteriorly), and transversalis fascia (posteriorly).[Wikipedia:Kidney_capsule] EMAPA:18679 @@ -80888,10 +81357,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal capsule uberon UBERON:0002015 + kidney capsule - Illu:kidney.jpg + https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg @@ -80948,6 +81418,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. + Any of the veins which collect blood from the lungs and some small vesicles received from the esophagus.[AAO] One of two pairs of large vessels that return oxygenated blood from each lung to the left atrium of the heart. [TFD][VHOG] the veins that return oxygenated blood from the lungs to the left atrium of the heart @@ -80974,10 +81445,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon venae pulmonales UBERON:0002016 + pulmonary vein - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -81017,7 +81489,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001133 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -81047,6 +81519,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + BTO:0001792 CALOHA:TS-0814 EHDAA2:0001485 @@ -81066,6 +81539,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An portal venous tree organ part uberon UBERON:0002017 + portal vein @@ -81132,7 +81606,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000699 Wikipedia:Spinal_accessory_nerve XAO:0004214 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2085 + neuronames:2085 Willis' nerve accessory XI accessory XI nerve @@ -81168,7 +81642,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An http://code.google.com/p/xenopus-anatomy-ontology/issues/detail?id=7 - VHOG + VHOG Wikipedia @@ -81184,7 +81658,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerve that innervates the sternocleidomastoid and trapezius complex of muscles. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-1, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] 2012-09-17 VHOG:0000699 - VHOG + VHOG http://bgee.unil.ch/ @@ -81202,7 +81676,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG] 2012-09-17 VHOG:0000699 - VHOG + VHOG Wikipedia:Cranial_nerves http://bgee.unil.ch/ @@ -81312,6 +81786,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:67242 HBA:4006 MA:0001112 + MESH:D066128 NCIT:C32695 OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA TAO:0002197 @@ -81319,7 +81794,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001768 Wikipedia:Gray_matter ZFA:0001681 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2869 + neuronames:2869 gray matter gray matter of neuraxis grey matter @@ -81335,7 +81810,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gray matter - Spinal:nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -81404,7 +81879,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + Posterior part of the cerebral hemisphere (MSH). + BAMS:OL BAMS:Occipital_lobe BIRNLEX:1136 @@ -81417,20 +81899,22 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:678 HBA:4180 MAT:0000507 - MESH:A08.186.211.730.885.213.571 + MESH:D009778 NCIT:C12355 OpenCyc:Mx4rv9OFy5wpEbGdrcN5Y29ycA SCTID:180923002 UMLS:C0028785 Wikipedia:Occipital_lobe - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=140 + neuronames:140 regio occipitalis uberon lobus occipitalis UBERON:0002021 + + In some species, parcellations of lobes are not well defined or at all, and therefore the occipital lobe could refer to the most posterior mammalian cerebral cortex. occipital lobe http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray727_occipital_lobe.png @@ -81461,7 +81945,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=140 + neuronames:140 BIRNLEX:1136 @@ -81494,6 +81978,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells. + replaces damaged cells on outside of body consisting of non-keratinized, viable cells, in contrast to the outer (upper) layer of epidermis made up of keratinized, anucleated, non-viable cells Malpighian layer @@ -81529,6 +82014,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epidermis sensorial layer epidermis stratum germinativum UBERON:0002025 + stratum basale of epidermis @@ -81604,6 +82090,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance. + Has cells that produce and secrete bipolar lipids which prevent evaporation, helping to 'water-proof' the skin. Keratinization begins in the stratum spinosum. [Wikipedia:Stratum_spinosum] Malpighian layer stratum Malpighii @@ -81623,6 +82110,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epidermis prickle cell layer prickle cell layer UBERON:0002026 + stratum spinosum of epidermis @@ -81673,6 +82161,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells. + The keratinized outermost layer of the epidermis, which is periodically shed.[AAO] some oral epitehlium also has cornified layer / stratum corneum horny layer @@ -81695,10 +82184,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon stratum corneum epidermidis UBERON:0002027 + stratum corneum of epidermis - Epidermal:layers.png http://upload.wikimedia.org/wikipedia/commons/2/20/Skinlayers.png + https://upload.wikimedia.org/wikipedia/commons/e/e4/Epidermal_layers.png @@ -81759,6 +82249,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] @@ -81792,11 +82283,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Rhombencephalon XAO:0000015 ZFA:0000029 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 + neuronames:540 uberon rhombencephalon UBERON:0002028 + @@ -81829,7 +82321,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA ABA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -81876,7 +82368,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000070 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -81906,7 +82398,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 + neuronames:540 BIRNLEX:942 @@ -82232,8 +82724,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An areola - Female:Areola.jpg http://upload.wikimedia.org/wikipedia/commons/f/f4/Brustwarze.JPG + https://upload.wikimedia.org/wikipedia/commons/a/ad/Female_Areola.jpg @@ -82330,7 +82822,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A tiny smooth muscle that connects the hair follicle with the dermis. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -82445,7 +82937,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12908 MA:0000843 MBA:286 - MESH:A08.186.211.730.385.357.342.625 + MESH:D013493 NCIT:C74537 SCTID:369132004 TAO:0000441 @@ -82455,7 +82947,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Suprachiasmatic_nucleus XAO:0004072 ZFA:0000441 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=384 + neuronames:384 suprachiasmatic nucleus of hypothalamus uberon SCN @@ -82549,7 +83041,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=384 + neuronames:384 BIRNLEX:1325 @@ -82612,7 +83104,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Muscle tissue that contains fibers that are divided by transverse bands into striations. CL:0000737 - GOC:dph + GOC:dph GOC:mtg_muscle @@ -82656,6 +83148,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO] Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO] However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG] @@ -82693,18 +83186,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Cerebellum XAO:0003098 ZFA:0000100 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643 + neuronames:643 epencephalon-1 uberon corpus cerebelli parencephalon UBERON:0002037 + cerebellum - Cerebellum:NIH.png + https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png @@ -82758,7 +83252,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA ABA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -82833,7 +83327,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643 + neuronames:643 BIRNLEX:1489 @@ -82871,6 +83365,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM). TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA + Subdivision of the midbrain anterior to the midbrain tegmentum which contains darkly pigmented neurons[FMA][FMA:67947]. (...) the substantia nigra first appears in reptiles and is best developed in primates.[well established][VHOG] SN @@ -82888,14 +83383,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9072 MA:0000210 MAT:0000504 - MESH:A08.186.211.132.659.687 + MESH:D013378 NCIT:C12453 SCTID:279286002 UMLS:C0038590 UMLS:C1269578 VHOG:0001573 Wikipedia:Substantia_nigra - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=536 + neuronames:536 Soemmering's substance nucleus of basis pedunculi uberon @@ -82904,6 +83399,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An substantia nigra (Soemmerringi) UBERON:0002038 + substantia nigra @@ -82971,7 +83467,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=536 + neuronames:536 BIRNLEX:789 @@ -83008,6 +83504,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An endothelium that is part of a lymphatic vessel [Automatically generated definition]. + The vascular endothelium that lines the lymph vessels.[TAO] BTO:0004303 CALOHA:TS-2156 @@ -83026,6 +83523,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lymphatic vessel endothelium uberon UBERON:0002042 + lymphatic vessel endothelium @@ -83219,6 +83717,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Respiration organ that develops as an outpocketing of the esophagus. + Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO] Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG] pulmonary @@ -83251,6 +83750,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0002048 + @@ -83280,14 +83780,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - BGEE:fb + https://orcid.org/0000-0002-9415-5104 https://github.com/obophenotype/uberon/issues/701 - BGEE:fb + https://orcid.org/0000-0002-9415-5104 https://github.com/obophenotype/uberon/issues/701 @@ -83336,6 +83836,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. see also: vascular system. Consider merging? + vascular BTO:0003718 FMA:69050 @@ -83344,6 +83845,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vascular network uberon UBERON:0002049 + @@ -83502,6 +84004,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium that is part of a bronchiole [Automatically generated definition]. + in FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however there are two distinct terms for the corresponding epithelium. BTO:0001866 CALOHA:TS-0570 @@ -83521,6 +84024,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lobular bronchiole epithelium uberon UBERON:0002051 + epithelium of bronchiole @@ -83662,7 +84166,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced. MESH:A06.407.071.140.960 - MGI:llw2 + MGI:llw2 MP:0008293 @@ -84085,6 +84589,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16696 FMA:70302 MA:0000078 + MESH:D054089 TAO:0001317 VHOG:0000932 Wikipedia:Atrioventricular_cushions @@ -84243,7 +84748,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -84287,7 +84792,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] 2012-09-17 VHOG:0000177 - VHOG + VHOG ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 http://bgee.unil.ch/ @@ -84585,6 +85090,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. [WP,unvetted]. + BTO:0001509 CALOHA:TS-1082 EFO:0001940 @@ -84607,6 +85113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vena umbilicalis UBERON:0002066 + umbilical vein @@ -84655,6 +85162,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. Consider adding a layer-of-skin grouping class for all skin layers + A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] dermal @@ -84684,6 +85192,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cutis UBERON:0002067 + @@ -84793,7 +85302,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:70343 GAID:1313 MA:0001701 - MESH:A16.254.835 + MESH:D014497 NCIT:C12338 RETIRED_EHDAA2:0002138 SCTID:276858000 @@ -84873,6 +85382,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis. + BTO:0000361 EMAPA:32786 FMA:70344 @@ -84887,6 +85397,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon epidermis granular layer UBERON:0002069 + stratum granulosum of epidermis @@ -84941,7 +85452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0221922 UMLS:C1514985 Wikipedia:Stratum_lucidum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1777 + neuronames:1777 epidermis stratum lucidum stratum conjunctum of epidermis uberon @@ -84990,6 +85501,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. hypodermal @@ -85015,6 +85527,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An superficial fascia tela subcutanea UBERON:0002072 + @@ -85129,6 +85642,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO]. + The earliest reliable record of hair is found in a fossil of the Paleocene period, in which the structure of hair cuticles is preserved. Its appearance suggests that the complicated structure of the hair follicle, closely similar to that of present-day mammals, had already appeared at this time.[well established][VHOG] BTO:0000554 CALOHA:TS-0432 @@ -85150,12 +85664,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An folliculus pili UBERON:0002073 + Development notes:Formation largely takes place during fetal and perinatal skin development. However, after skin wounding de novo hair follicle formation may also occur in adult mouse and rabbit skin[DOI:10.1016/j.cub.2008.12.005]. hair follicle - Hair:follicle-en.svg + https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg @@ -85387,7 +85902,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Smooth and glossy outer protective cell layer of hair shaft. - MGI:llw2 + MGI:llw2 MP:0003810 @@ -85459,6 +85974,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cardiac atrium that is in the left side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA] The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern @@ -85485,6 +86001,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon atrium dextrum UBERON:0002078 + right cardiac atrium @@ -85510,7 +86027,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000328 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -85547,6 +86064,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. + Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA] The chamber of the heart that receives blood from the lungs[XAO:EJS]. The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG] @@ -85574,6 +86092,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An left cardiac atrium uberon UBERON:0002079 + left cardiac atrium @@ -85605,7 +86124,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000369 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -85648,6 +86167,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cardiac ventricle that is in the right side of the heart. + The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern In mammals continuous with the pulmonary arteries @@ -85672,6 +86192,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An right cardiac ventricle ventriculus dexter UBERON:0002080 + heart right ventricle @@ -86049,6 +86570,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cardiac ventricle that is in the left side of the heart. + Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG] https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern @@ -86074,6 +86596,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon ventriculus sinister cordis UBERON:0002084 + heart left ventricle @@ -86190,7 +86713,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000385 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -86684,6 +87207,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. + The partition separating the right and left ventricles of the heart. [TFD][VHOG] The two most progressive vertebrate classes, the birds and mammals, have completed the ventricular septum and at long last have completely separated the two blood streams along the length of the major heart chambers. This development has obviously been brought about independently in the two cases, since mammals and birds have evolved independently from primitive reptiles.[well established][VHOG] involves the recruitment of myocardial cells as well as of non- muscular mesenchymal cells (Kaufman and Bard, 1999) @@ -86713,6 +87237,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ventricular septum UBERON:0002094 + interventricular septum @@ -86827,7 +87352,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100083 FMA:7144 GAID:21 - MESH:A01.047.025.600.451 + MESH:D008643 NCIT:C33103 SCTID:362707009 UMLS:C0025474 @@ -86898,6 +87423,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The organ covering the body that consists of the dermis and epidermis. consider 'integumentary system' for invertebrates + MA uses the term skin to refer to what is called here: zone of skin BTO:0001253 CALOHA:TS-0934 @@ -86924,6 +87450,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An skin UBERON:0002097 + @@ -87072,7 +87599,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this - GO + GO @@ -87163,7 +87690,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -87281,7 +87808,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000336 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -87528,7 +88055,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000337 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -87712,6 +88239,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The organ that functions to filter blood and to store red corpuscles and platelets. + An organ involved in red blood cell filtration and immune response.[AAO] With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG] lienal @@ -87729,7 +88257,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1289 MA:0000141 MAT:0000085 - MESH:A15.382.520.604.713 + MESH:D013154 MIAA:0000085 NCIT:C12432 OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA @@ -87745,12 +88273,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lien UBERON:0002106 + spleen - Illu:spleen.jpg + https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg @@ -87826,6 +88355,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + Organ which secretes bile and participates in formation of certain blood proteins.[AAO] relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG] @@ -87863,13 +88393,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An jecur UBERON:0002107 + liver - Leber:Schaf.jpg + https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg @@ -87987,6 +88518,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. + The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO] Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG] AAO:0010397 @@ -87999,7 +88531,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:313 MA:0000337 MAT:0000047 - MESH:A03.492.411.620 + MESH:D007421 MIAA:0000047 NCIT:C12386 OpenCyc:Mx4rvVjlIJwpEbGdrcN5Y29ycA @@ -88019,6 +88551,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mid intestine UBERON:0002108 + @@ -88151,8 +88684,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) gall bladder - Abdomal:organs.svg https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg + https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg @@ -88479,6 +89012,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A paired organ of the urinary tract which has the production of urine as its primary function. + One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO] renal @@ -88505,6 +89039,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0002113 + @@ -88578,6 +89113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] duodenal In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine may be used instead of duodenum. @@ -88592,7 +89128,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:284 MA:0000338 MAT:0000044 - MESH:A03.492.411.620.270 + MESH:D004386 MIAA:0000044 NCIT:C12263 OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA @@ -88607,6 +89143,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An upper intestine UBERON:0002114 + @@ -88695,6 +89232,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the small intestine that extends from the duodenum to the ileum. TODO consider ZFA:0001323 mid intestine, see also small intestine + The first two fifth of the small intestine beyond the duodenum. It extends from the end of the duodenum to the ileum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] jejunal The jejunum is the middle section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms middle intestine or mid-gut may be used instead of jejunum.[Wikipedia:Jejunum] @@ -88707,7 +89245,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:318 MA:0000340 MAT:0000045 - MESH:A03.492.411.620.625 + MESH:D007583 MIAA:0000045 NCIT:C12388 OpenCyc:Mx4rwATkPJwpEbGdrcN5Y29ycA @@ -88722,6 +89260,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An middle intestine UBERON:0002115 + jejunum @@ -88800,6 +89339,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the small intestine that extends from the jejunum to the colon. TODO consider ZFA:0000706 posterior intestine, see also colon + Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG] ileal The ileum is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine may be used instead of ileum.[Wikipedia:Ileum] @@ -88813,7 +89353,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:315 MA:0000339 MAT:0000282 - MESH:A03.492.411.620.484 + MESH:D007082 MIAA:0000282 NCIT:C12387 OpenCyc:Mx4rvdcLHZwpEbGdrcN5Y29ycA @@ -88830,6 +89370,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An posterior intestine UBERON:0002116 + ileum @@ -88926,6 +89467,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16579 FMA:72170 MAT:0000117 + MESH:D060910 MIAA:0000117 NCIT:C34280 SCTID:308804007 @@ -89047,6 +89589,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The fibrous connective tissue surrounding the thymus. + EMAPA:19306 FMA:72204 MA:0000766 @@ -89057,6 +89600,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus capsule uberon UBERON:0002122 + capsule of thymus @@ -89088,6 +89632,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes. + Histologically, the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin[WP] BTO:0002934 EMAPA:35863 @@ -89101,6 +89646,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus cortex uberon UBERON:0002123 + cortex of thymus @@ -89115,7 +89661,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -89151,6 +89697,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size. + BTO:0004560 EFO:0001969 EMAPA:19305 @@ -89166,6 +89713,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0002124 + medulla of thymus @@ -89179,7 +89727,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -89214,6 +89762,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified]. + in the mouse, the lobes of the thymus are not subdivided into lobules but only in the central medulla and a peripheral cortex (i.e. there is no distinct sublobulation). In humans, the two thymus lobes are composed of many lobules of various sizes which contain follicles, each comprising a medulla and a cortex. in the rat, the thymus is partially subdivided into lobules separated by thin bands of connective tissue which are continuous with the thin connective tissue capsule.[MP] Lymphocytes, reticular cells and macrophages are found in the lobules FMA:72215 @@ -89226,6 +89775,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus lobule uberon UBERON:0002125 + thymus lobule @@ -89296,7 +89846,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001627 Wikipedia:Inferior_olivary_nucleus ZFA:0000215 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=748 + neuronames:748 inferior olivary nuclear complex inferior olive oliva @@ -89398,7 +89948,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=748 + neuronames:748 BIRNLEX:1164 @@ -89526,10 +90076,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9177 MA:0001026 MBA:398 + MESH:D065832 UMLS:C0175427 VHOG:0001381 Wikipedia:Superior_olivary_complex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=569 + neuronames:569 nucleus olivaris superior superior olivary nuclei uberon @@ -89587,7 +90138,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=569 + neuronames:569 BIRNLEX:1307 @@ -89647,6 +90198,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer. + The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function[GO][GO:0021695]. BAMS:CB BAMS:CBX @@ -89671,17 +90223,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1284087 VHOG:0001597 Wikipedia:Cerebellar_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=647 + neuronames:647 cortex of cerebellar hemisphere uberon cortex cerebellaris cortex cerebelli UBERON:0002129 + The circuits in the cerebellar cortex look similar across all classes of vertebrates, including fish, reptiles, birds, and mammals (e.g., Fig. 2). This has been taken as evidence that the cerebellum performs functions important to all vertebrate species. (Wikipedia) cerebellar cortex - Cerebellum:NIH.png + https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png @@ -89722,7 +90275,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=647 + neuronames:647 BIRNLEX:1566 @@ -89776,7 +90329,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MESH:D002529 UMLS:C0007763 Wikipedia:Deep_cerebellar_nuclei - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=682 + neuronames:682 central nuclei cerebellar nuclei deep cerebellar nuclear complex @@ -89824,7 +90377,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=682 + neuronames:682 BIRNLEX:1568 @@ -89885,7 +90438,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279359004 VHOG:0001598 Wikipedia:Anterior_lobe_of_cerebellum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=650 + neuronames:650 anterior cerebellar lobe anterior lobe of cerebellum anterior lobe of the cerebellum @@ -89943,7 +90496,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0086120 VHOG:0001700 Wikipedia:Dentate_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=683 + neuronames:683 dentate cerebellar nucleus lateral cerebellar nucleus lateral nucleus of cerebellum @@ -89992,7 +90545,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=683 + neuronames:683 BIRNLEX:1171 @@ -90158,6 +90711,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An atrioventricular valve that is part of the outflow part of the right atrium. + The three-segmented valve of the heart that keeps blood in the right ventricle from flowing back into the right atrium. [TFD][VHOG] The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG] FMA part_ofs changed to connects @@ -90181,6 +90735,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon valvula tricuspidalis UBERON:0002134 + tricuspid valve @@ -90259,6 +90814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An atrioventricular valve that is part of the outflow part of the left atrium. + A valve of the heart, composed of two triangular flaps, that is located between the left atrium and left ventricle and regulates blood flow between these chambers. [TFD][VHOG] The mature AV (atrioventricular) valve of the adult zebrafish 2-chambered heart is structurally similar to the mammalian AV valves with stratified ECM (extracellular matrix) and supporting chordae tendineae. Therefore, the major cellular and molecular events of valve development are largely conserved among animals with hearts composed of multiple chambers.[well established][VHOG] FMA part_ofs changed to connects @@ -90283,6 +90839,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An valva mitralis UBERON:0002135 + mitral valve @@ -90355,6 +90912,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA]. + The valve between the left ventricle of the heart and the ascending aorta, consisting of three semilunar cusps. [TFD][VHOG] BTO:0004628 EFO:0003879 @@ -90376,6 +90934,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An valva aortae UBERON:0002137 + Human variation: It is normally tricuspid (with three leaflets), although in 1% of the population it is found to be congenitally bicuspid (two leaflets) @@ -90450,13 +91009,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:794 HBA:9489 MA:0002941 - MESH:A08.713.810 + MESH:D013351 SCTID:369193006 TAO:0000683 UMLS:C0038533 Wikipedia:Subcommissural_organ ZFA:0000683 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=483 + neuronames:483 uberon SCO cerebral aqueduct subcommissural organ @@ -90510,7 +91069,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=483 + neuronames:483 BIRNLEX:1028 @@ -90541,6 +91100,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery. + The valve with semilunar cusps at the entrance to the pulmonary trunk from the right ventricle of the heart. [TFD][VHOG] EHDAA2:0001577 EHDAA:4412 @@ -90560,6 +91120,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon valva trunci pulmonalis UBERON:0002146 + pulmonary valve @@ -90602,6 +91163,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + @@ -90635,7 +91198,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0023951 Wikipedia:Locus_ceruleus ZFA:0000539 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=583 + neuronames:583 + Noradrenergic cell group A6 blue nucleus caerulean nucleus locus caeruleus @@ -90717,9 +91281,15 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=583 + neuronames:583 BIRNLEX:905 + + + + Noradrenergic cell group A6 + Noradrenergic_cell_group_A6&oldid=981960774 + @@ -90787,6 +91357,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM). we follow NIF in dividing this into 3 parts. This allows for consistency with ABA + we make the TAO class disjoint for now as it's not clear if this is the analagous structure BAMS:5 BAMS:scp @@ -90800,7 +91371,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279218008 UMLS:C0152391 Wikipedia:Superior_cerebellar_peduncle - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1736 + neuronames:1736 brachium conjunctivum uberon crus cerebello-cerebrale @@ -90816,6 +91387,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tractus cerebello-rubralis tractus cerebello-tegmentalis mesencephali UBERON:0002150 + superior cerebellar peduncle @@ -90831,7 +91403,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An we make the TAO class disjoint for now as it's not clear if this is the analagous structure - TAO + TAO @@ -90842,7 +91414,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1736 + neuronames:1736 BIRNLEX:1711 @@ -90946,6 +91518,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM). + BAMS:BP BAMS:bp BAMS:mcp @@ -90956,11 +91529,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9294 MA:0002745 MBA:78 + MESH:D065837 NIFSTD_RETIRED:birnlex_1699 SCTID:279219000 UMLS:C0152392 Wikipedia:Middle_cerebellar_peduncle - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=620 + neuronames:620 brachium pontis uberon brachium pontis (stem of middle cerebellar peduncle) @@ -90971,6 +91545,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pedunculus cerebellaris medius pedunculus cerebellaris pontinus UBERON:0002152 + middle cerebellar peduncle @@ -91002,7 +91577,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=620 + neuronames:620 BIRNLEX:1529 @@ -91085,7 +91660,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0175490 VHOG:0001699 Wikipedia:Fastigial_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=690 + neuronames:690 medial (fastigial) nucleus medial cerebellar nucleus nucleus fastigii @@ -91137,7 +91712,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=690 + neuronames:690 BIRNLEX:1146 @@ -91247,7 +91822,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1289468 Wikipedia:Area_postrema ZFA:0005146 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=772 + neuronames:772 uberon chemoreceptor trigger zone UBERON:0002162 @@ -91362,7 +91937,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=772 + neuronames:772 BIRNLEX:2636 @@ -91380,6 +91955,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Regional part of medullary white matter (according to Neuronames) primarily found at the level of the open medulla, consisting of a large bundle of fibers projecting to and projecting from the cerebellum. The icp is continuous with the dorsal spinocerebellar tract and also contains a large number of fibers originating in the inferior olivary complex (MM). + BAMS:icp BIRNLEX:1691 BM:RB @@ -91393,7 +91969,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362418008 UMLS:C0152393 Wikipedia:Inferior_cerebellar_peduncle - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=781 + neuronames:781 corpus restiforme restiform body uberon @@ -91405,6 +91981,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pedunculus cerebellaris caudalis pedunculus cerebellaris inferior UBERON:0002163 + inferior cerebellar peduncle @@ -91425,7 +92002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=781 + neuronames:781 BIRNLEX:1691 @@ -92122,6 +92699,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli. + In human anatomy, respiratory bronchioles exists proximal to the alveolar ducts. The epithelial lining consists of smooth muscle knobs covered by nonciliated, simple cuboidal cells. The smooth muscle constricts under parasympathetic innervation and relax under sympathetic innervation EMAPA:32694 FMA:7341 @@ -92135,6 +92713,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An respiratory alveolar duct uberon UBERON:0002173 + pulmonary alveolar duct @@ -92387,7 +92966,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000533 Wikipedia:Lateral_funiculus ZFA:0000533 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1673 + neuronames:1673 lateral funiculus lateral funiculus of spinal cord lateral white column of spinal cord @@ -92446,7 +93025,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000605 Wikipedia:Ventral_funiculus ZFA:0000605 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1304 + neuronames:1304 anterior funiculus anterior funiculus of spinal cord anterior white column of spinal cord @@ -92515,6 +93094,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of two branches of the trachea. + In humans, histologically identical to trachea. EHDAA2:0001044 EHDAA:3072 @@ -92537,6 +93117,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An proximal bronchus UBERON:0002182 + main bronchus @@ -92714,6 +93295,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32697 FMA:7410 MA:0000422 + MESH:D055745 NCIT:C12684 OpenCyc:Mx4rvl9iDpwpEbGdrcN5Y29ycA SCTID:278982001 @@ -92728,7 +93310,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An bronchiole - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -92798,6 +93380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls. + BTO:0003223 EMAPA:36282 FMA:7411 @@ -92812,10 +93395,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An bronchioli terminalis terminal bronchiole tube UBERON:0002187 + terminal bronchiole - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -92858,6 +93442,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bronchiole that is the first segment of the respiratory zone. + mice have few or none of these structures, with the terminal bronchioles transitioning directly to the alveolary ducts BTO:0003222 EMAPA:35729 @@ -92872,10 +93457,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An bronchiolus respiratorius uberon UBERON:0002188 + respiratory bronchiole - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -92936,6 +93522,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156] UBERON:0008875 panniculus adiposus @@ -92952,6 +93539,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fatty layer of superficial fascia subcutaneous fat UBERON:0002190 + subcutaneous adipose tissue @@ -93060,7 +93648,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369097009 UMLS:C0152316 Wikipedia:Subiculum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=188 + neuronames:188 subicular cortex subiculum hippocampi uberon @@ -93070,7 +93658,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An subiculum - Hippocampus:(brain).jpg + https://upload.wikimedia.org/wikipedia/commons/9/99/Hippocampus.gif @@ -93189,15 +93777,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Membranous process coming from capsule of lymph node[WP]. + FMA:74605 MA:0000746 NCIT:C33035 UMLS:C1184179 Wikipedia:Lymph_node_trabeculae lymph node trabecula + lymph node trabeculae lymph node trabeculum + trabeculae of lymph node uberon UBERON:0002195 + trabecula of lymph node http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png @@ -93214,6 +93806,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1184179 ncithesaurus:Lymph_Node_Trabecula + + + + lymph node trabeculae + + + + + + trabeculae of lymph node + + @@ -93254,7 +93858,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17514 FMA:74627 MA:0000177 - MESH:A06.407.747.608 + MESH:D010903 NCIT:C12772 SCTID:245532007 TAO:0001282 @@ -93263,7 +93867,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000141 Wikipedia:Adenohypophysis ZFA:0001282 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=407 + neuronames:407 anterior hypophysis anterior lobe (hypophysis) anterior lobe of hypophysis @@ -93371,7 +93975,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=407 + neuronames:407 BIRNLEX:1581 @@ -93472,12 +94076,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12916 MA:0000859 MBA:10671 - MESH:A06.407.747.734.500 + MESH:D008473 SCTID:369121004 UMLS:C0025056 VHOG:0001179 Wikipedia:Median_eminence - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=402 + neuronames:402 eminentia mediana hypothalami median eminence median eminence of hypothalamus @@ -93537,7 +94141,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=402 + neuronames:402 BIRNLEX:925 @@ -93624,7 +94228,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17519 FMA:74628 MA:0000178 - MESH:A06.407.747.734 + MESH:D010904 NCIT:C12773 SCTID:245527006 TAO:0001271 @@ -93633,7 +94237,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000142 Wikipedia:Neurohypophysis ZFA:0001271 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=401 + neuronames:401 infundibular process lobus nervosus neurohypophysis lobus posterior (glandula pituitaria) @@ -93750,7 +94354,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=401 + neuronames:401 BIRNLEX:1586 @@ -94140,6 +94744,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A submucosa that is part of a trachea. + BTO:0002115 EMAPA:35879 FMA:7472 @@ -94154,6 +94759,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon submucous layer of trachea UBERON:0002202 + submucosa of trachea @@ -94208,6 +94814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Vasculature that is part of the eye region. + not part of the eye in ZFA. Note this changed to a blood vessel in ZFA FMA:74743 SCTID:123846009 @@ -94221,6 +94828,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An eye vasculature optic vasculature UBERON:0002203 + vasculature of eye @@ -94234,7 +94842,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ISBN:0781772214 + ISBN:0781772214 @@ -94454,7 +95062,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12909 MA:0000174 MBA:331 - MESH:A08.186.211.730.385.357.362.500 + MESH:D008326 NCIT:C33052 SCTID:279306001 TAO:0000334 @@ -94462,7 +95070,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1305759 Wikipedia:Mammillary_body ZFA:0000334 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=412 + neuronames:412 corpus mamillare uberon corpora mamillaria @@ -94565,7 +95173,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=412 + neuronames:412 BIRNLEX:865 @@ -95471,7 +96079,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + @@ -95479,7 +96087,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]. - TODO - check Anatomical structure that is a membranous gap between bones of the skull.[TAO] FMA:75438 MA:0001465 @@ -95499,14 +96106,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fontanelle + https://github.com/obophenotype/uberon/issues/1795 http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray197.png - - - - - FMA - @@ -95524,6 +96126,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP]. Wikipedia:Fontanelle + https://orcid.org/0000-0002-2825-0621 @@ -95716,12 +96319,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - @@ -95734,7 +96331,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:7565 GAID:93 MA:0000032 - MESH:A01.911.800 + MESH:D035423 NCIT:C12905 OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA @@ -96326,7 +96923,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:75805 GAID:876 MA:0001199 - MESH:A09.246.631.246.292.906 + MESH:D013680 NCIT:C33740 SCTID:368960006 UMLS:C0039432 @@ -96463,6 +97060,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35262 FMA:7591 MA:0000106 + MESH:D066186 NCIT:C32391 OpenCyc:Mx4rwP1g3pwpEbGdrcN5Y29ycA SCTID:244703004 @@ -96688,7 +97286,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Spinal_cord XAO:0000020 ZFA:0000075 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 + neuronames:22 uberon SpC cerebro-cerebellar fissure @@ -96732,7 +97330,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -96768,7 +97366,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 + neuronames:22 BIRNLEX:1709 @@ -96922,6 +97520,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:13550 FMA:76703 MA:0000112 + MESH:D000070614 SCTID:316586000 Wikipedia:Nucleus_pulposus nucleus pulposus (diskus intervertebralis) @@ -96954,7 +97553,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord. - MGI:llw2 + MGI:llw2 MP:0006392 @@ -97200,7 +97799,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362411002 UMLS:C0228465 Wikipedia:Cerebellar_hemisphere - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1214 + neuronames:1214 cerebellar hemisphere cerebellum hemisphere hemisphere of cerebellum @@ -97359,7 +97958,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thyroglossal duct - Illu08:thyroid.jpg + https://upload.wikimedia.org/wikipedia/commons/f/fd/Illu08_thyroid.jpg @@ -97377,7 +97976,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA - VHOG + VHOG @@ -97391,7 +97990,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An embryonic duct extending between the thyroid primordium and the posterior tongue. [TFD][VHOG] 2012-09-17 VHOG:0000746 - VHOG + VHOG http://bgee.unil.ch/ http://medical-dictionary.thefreedictionary.com/thyroglossal+duct @@ -97401,7 +98000,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A duct, called the thyroglossal duct in mammals, is considered to be characteristic of thyroid development. The thyroglossal duct, degenerating in many species during late development, marks the way the thyroid primordium relocates during embryonic development from the pharynx to its position deep in the cervical mesenchyme. We cannot exclude that the duct of the endostyle and the thyroglossal duct may have evolved independently, but as they both represent a more or less persistent connection of the organ to the pharynx, it is likely that they are homologous structures.[well established][VHOG] 2012-09-17 VHOG:0000746 - VHOG + VHOG DOI:10.1007/s00427-004-0450-0 Kluge B, Renault N, Rohr KB, Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution. Development genes and evolution (2005) http://bgee.unil.ch/ @@ -97469,12 +98068,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:77280 GAID:354 MA:0000289 - MESH:A04.531.591.940 + MESH:D019147 SCTID:361346007 VHOG:0000665 Wikipedia:Vomeronasal_organ XAO:0000272 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1566 + neuronames:1566 Jacobson's organ organon vomeronasale organum vomeronasale @@ -97585,7 +98184,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001287 Wikipedia:Posterior_horn_of_spinal_cord ZFA:0000649 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1686 + neuronames:1686 columna grisea posterior medullae spinalis cornu dorsale cornu posterius medullae spinalis @@ -97753,7 +98352,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001288 Wikipedia:Anterior_horn_of_spinal_cord ZFA:0000702 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1751 + neuronames:1751 anterior gray column of spinal cord anterior gray horn of spinal cord anterior grey column of spinal cord @@ -97915,7 +98514,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000501 Wikipedia:Dorsal_funiculus ZFA:0000501 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1692 + neuronames:1692 dorsal funiculus dorsal funiculus of spinal cord dorsal white column of spinal cord @@ -97998,12 +98597,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:242157 GAID:574 MA:0002567 - MESH:A08.186.211.132.659.237 + MESH:D003336 NCIT:C12461 SCTID:361579006 UMLS:C0010087 Wikipedia:Corpora_quadrigemina - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1279 + neuronames:1279 colliculi corpora quadrigemina quadrigeminal body @@ -98062,7 +98661,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0205956 Wikipedia:Anterior_root_of_spinal_nerve ZFA:0000705 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2620 + neuronames:2620 anterior spinal root ventral spinal root uberon @@ -98085,7 +98684,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ventral root of spinal cord - Spinal:nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -98228,7 +98827,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0205955 Wikipedia:Posterior_root_of_spinal_nerve ZFA:0000652 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1661 + neuronames:1661 dorsal root dorsal root of spinal nerve dorsal spinal nerve root @@ -98250,7 +98849,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An dorsal root of spinal cord - Spinal:nerve.svg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -98379,6 +98978,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]. + Part of the rostral part of the cerebrum where axons of olfactory cells from the nasal mucosa terminate. Projects onto olfactory parts of pallium via olfactory tracts Part of the telencephalon comprised of anterior outgrowths of either of the cerebral hemispheres in which the olfactory nerve exits.[AAO] Segment of neural tree organ which is continuous with a set of olfactory nerves and an olfactory tract[FMA:77624]. @@ -98403,7 +99003,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:633 HBA:9303 MA:0000194 - MESH:A08.186.211.577.699.573 + MESH:D009830 NCIT:C28401 SCTID:279394006 TAO:0000402 @@ -98412,7 +99012,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Olfactory_bulb XAO:0004180 ZFA:0000402 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 + neuronames:279 bulbus olfactorius uberon bulbus olfactorius @@ -98420,6 +99020,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An olfactory lobe olfactory lobe (Barr & Kiernan) UBERON:0002264 + @@ -98507,7 +99108,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 + neuronames:279 BIRNLEX:1137 @@ -98556,6 +99157,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An White matter tract that contains projections from the olfactory bulb to other parts of the brain. + A nervelike, white band composed primarily of nerve fibres originating from the mitral cells and tufted cells of the olfactory bulb but also containing the scattered cells of the anterior olfactory nucleus[BTO:0003647]. The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. It lies in the olfactory sulcus on the inferior surface of the frontal lobe, and divides posteriorly into two striæ, a medial olfactory stria and a lateral olfactory stria.[Wikipedia]. Tract of brain which is continuous with olfactory bulb and the cerebral cortex.[FMA] @@ -98575,7 +99177,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362356008 UMLS:C0162435 Wikipedia:Olfactory_tract - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=283 + neuronames:283 uberon olfactory peduncle olfactory stalk @@ -98583,6 +99185,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tractus olfactorium tractus olfactorius UBERON:0002265 + olfactory tract @@ -98626,7 +99229,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The definition was adapted from the NIFSTD class which has been retired. It has been generalized so it is applicable to various different kinds of olfactory tracts found in different taxa. - cjm + cjm ISBN:0471888893 @@ -98638,7 +99241,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=283 + neuronames:283 BIRNLEX:1663 @@ -98773,6 +99376,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens. + Artery that is internal to the eye. Isogai et al. 2001.[TAO] In humans, Usually fully regressed before birth, its purpose is to supply nutrient to the developing lens in the growing fetus. During the tenth week of development the lens grows independent of a blood supply and the hyaloid artery usually regresses. Its proximal portion remains as the central artery of the retina. Regression of the hyaloid artery leaves a clear central zone through the vitreous called the hyaloid canal or Cloquet's canal. Occasionally the artery may not fully regress, resulting in the condition persistent hyaloid artery. More commonly, small remnants of the artery may remain. Free remnants can sometimes be seen as 'floaters'. An anterior remnant of the hyaloid artery can be seen in some people as Mittendorf's dot, a small pinpoint-like scar on the posterior surface of the lens. A posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister's papilla EHDAA2:0004072 @@ -98791,6 +99395,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An central artery of retina hyaloid arteries UBERON:0002270 + @@ -98903,7 +99508,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000846 MBA:157 VHOG:0000623 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2292 + neuronames:2292 hypothalamus periventricular zone zona periventricularis hypothalamicae uberon @@ -98945,7 +99550,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:77683 MA:0000837 MBA:467 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2291 + neuronames:2291 hypothalamus medial zone zona medialis hypothalamicae uberon @@ -99089,7 +99694,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The fluid-filled space separating the membranous from the osseous labyrinth. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -99483,6 +100088,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere. + The lateral ventricles are part of the ventricular system of the brain. Classified as part of the telencephalon, they are the largest of the ventricles. The lateral ventricles connect to the central third ventricle through the interventricular foramina of Monro[WP]. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle[GO]. The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] @@ -99514,7 +100120,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000643 Wikipedia:Lateral_ventricle ZFA:0000696 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=209 + neuronames:209 lateral ventricle lateral ventricles telencephalic ventricle @@ -99527,6 +100133,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An telencephalic vesicle UBERON:0002285 + @@ -99678,7 +100285,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000007 Wikipedia:Third_ventricle ZFA:0000161 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=446 + neuronames:446 3rd ventricle ventriculus diencephali diencephalic vesicle @@ -99782,6 +100389,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone). + The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] Two distinct classes in ncit. We classify this as a brain ventricle even though it is not classifically regarded as one (3rd = diencephalon, 4th = hindbrains) UBERON:0005684 @@ -99802,7 +100410,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:265505702 MA:0000208 MBA:140 - MESH:A08.186.211.132.659.822.187 + MESH:D002535 NCIT:C32135 SCTID:279249003 TAO:0000159 @@ -99810,8 +100418,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000832 Wikipedia:Cerebral_aqueduct ZFA:0000159 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=509 ncithesaurus:Cerebral_Aqueduct + neuronames:509 Sylvian aqueduct aqueduct (Sylvius) aqueduct of Sylvius @@ -99834,6 +100442,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mesencephalic vesicle UBERON:0002289 + @@ -100011,6 +100620,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord. + UBERON:0002220 BAMS:C BAMS:CC @@ -100029,7 +100639,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0459414 Wikipedia:Central_canal_of_spinal_cord ZFA:0000938 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1733 + neuronames:1733 canalis centralis central canal central canal of spinal cord @@ -100038,6 +100648,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon central canal, spinal cord/medulla UBERON:0002291 + @@ -100494,7 +101105,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001457 Wikipedia:Brainstem ZFA:0001707 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 + neuronames:236 brain stem truncus encephali uberon @@ -100535,7 +101146,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA ABA https://github.com/obophenotype/uberon/issues/378 - pending + pending @@ -100579,7 +101190,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 + neuronames:236 BIRNLEX:1565 @@ -100651,6 +101262,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]. + alveolus BTO:0000060 CALOHA:TS-0031 @@ -100674,10 +101286,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An respiratory alveoli UBERON:0002299 + alveolus of lung - Alveolus:diagram.svg + https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg @@ -100736,12 +101349,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets. cortical layer ABA:CTX1-6b @@ -101035,7 +101642,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0152289 VHOG:0001376 ZFA:0001447 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=218 + neuronames:218 chorioid plexus of cerebral hemisphere of lateral ventricle chorioid plexus of lateral ventricle choroid plexus telencephalic ventricle @@ -101164,7 +101771,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369096000 UMLS:C0152315 Wikipedia:Fimbria_of_hippocampus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=187 + neuronames:187 fimbria hippocampus fimbria of hippocampus fimbria of the fornix @@ -101233,7 +101840,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=187 + neuronames:187 BIRNLEX:1502 @@ -101315,7 +101922,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35409 FMA:83895 MA:0000956 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=156 + neuronames:156 pyramidal cell layer of the hippocampus pyramidal layer of hippocampus stratum pyramidale @@ -101340,7 +101947,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=156 + neuronames:156 BIRNLEX:1444 @@ -101422,7 +102029,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0039433 VHOG:0001388 Wikipedia:Midbrain_tectum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=465 + neuronames:465 mesencephalic tectum neuraxis tectum tectum @@ -101486,7 +102093,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=465 + neuronames:465 BIRNLEX:1032 @@ -101544,7 +102151,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLXANAT:100204 SCTID:279441003 UMLS:C0475853 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2619 + neuronames:2619 gray matter of spinal cord gray substance of spinal cord grey matter of spinal cord @@ -101620,6 +102227,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83929 HBA:9218 MA:0001135 + MESH:D066127 NCIT:C33892 NLX:412 NLXANAT:101177 @@ -101632,7 +102240,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001764 Wikipedia:White_matter ZFA:0001682 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2870 + neuronames:2870 CNS tract/commissure neuronal white matter white matter of neuraxis @@ -101646,8 +102254,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An white matter - Spinal:nerve.svg http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg + https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg @@ -101760,7 +102368,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0002183 UMLS:C0152381 ZFA:0001708 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=691 + neuronames:691 cerebellar white matter cerebellum white matter uberon @@ -101809,7 +102417,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=691 + neuronames:691 BIRNLEX:1562 @@ -101937,6 +102545,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries. + mesangial WP considers this the same as glomerular mesangium. In MA, glomerular and extraglomerular are distingsuished. FMA class has no definition and is a type of stroma, which is inconsistent with our classification of this here. BTO:0002494 @@ -101949,6 +102558,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Mesangium uberon UBERON:0002319 + mesangium @@ -101999,16 +102609,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A thin membrane which helps to support the capillary loops in a renal glomerulus. It is connective tissue composed of mesangial cells - myofibroblasts phenotypically related to vascular smooth muscle cells (muscle, smooth, vascular), phagocytes and the mesangial extracellular matrix. + EMAPA:27961 EMAPA:28248 FMA:84140 GAID:430 MA:0002606 - MESH:A05.810.453.736.520.380 + MESH:D005920 SCTID:244574009 Wikipedia:Glomerular_mesangium uberon UBERON:0002320 + glomerular mesangium @@ -102097,12 +102709,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - @@ -102353,7 +102959,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:85521 GAID:1311 MAT:0000281 - MESH:A16.254.610 + MESH:D009672 NCIT:C12463 SCTID:308820002 TAO:0000135 @@ -102513,7 +103119,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:85522 GAID:1306 MAT:0000068 - MESH:A16.254.425.660.750 + MESH:D019170 MIAA:0000068 NCIT:C34302 TAO:0000155 @@ -102712,6 +103318,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The connecting cord from the developing embryo to the placenta. + The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP]. umbilical BTO:0001415 @@ -102724,7 +103331,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:85541 GAID:517 MAT:0000280 - MESH:A16.254.789 + MESH:D014470 MIAA:0000280 NCIT:C34320 OpenCyc:Mx4rvyewDJwpEbGdrcN5Y29ycA @@ -102740,6 +103347,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An yolk stalk UBERON:0002331 + See notes for connecting stalk @@ -102814,6 +103422,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. + An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG] As in birds, the conus arteriosus split during embryonic development in mammals to produce the pulmonary trunk and single aortic trunk of the adult.[well established][VHOG] EHDAA2:0001576 @@ -102831,10 +103440,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An main pulmonary artery UBERON:0002333 + pulmonary trunk - Alveoli:diagram.png + https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png @@ -102977,6 +103587,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus[GO]. + not part of a nephron or distal tubule in MA and FMA BTO:0003940 EMAPA:28399 @@ -102988,6 +103599,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Macula_densa uberon UBERON:0002335 + macula densa @@ -103062,7 +103674,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000188 MAT:0000286 MBA:776 - MESH:A08.186.211.730.885.362 + MESH:D003337 MIAA:0000286 NCIT:C12446 OpenCyc:Mx4rvbNzdZwpEbGdrcN5Y29ycA @@ -103070,7 +103682,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0010090 VHOG:0001608 Wikipedia:Corpus_callosum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=191 + neuronames:191 uberon UBERON:0002336 @@ -103184,7 +103796,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:86666 GAID:1310 MAT:0000066 - MESH:A16.254.600 + MESH:D009432 MIAA:0000066 NCIT:C34222 SCTID:361462002 @@ -103194,7 +103806,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Neural_crest XAO:0000048 ZFA:0000045 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1366 + neuronames:1366 NC uberon crista neuralis @@ -103205,8 +103817,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest - Neural:Crest.png http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png + https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png @@ -103397,6 +104009,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + EFO:0002527 EMAPA:18605 FMA:87217 @@ -103405,6 +104018,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0002345 + descending thoracic aorta @@ -103434,7 +104048,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:255 EMAPA:16073 EV:0100004 - FBbt:00001061 + FBbt:00001057 FMA:87657 MAT:0000176 MIAA:0000176 @@ -103470,7 +104084,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000150 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -103583,6 +104197,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. + External layer of the heart.[TAO] The inner layer of the pericardium that is in contact with the surface of the heart.[AAO] The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium] @@ -103603,6 +104218,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon pericardium visceral mesothelium UBERON:0002348 + @@ -103905,6 +104521,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. + BTO:0004358 EHDAA2:0004184 EMAPA:35772 @@ -103934,6 +104551,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon nodus sinuatrialis UBERON:0002351 + @@ -104069,6 +104687,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. + Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG] BTO:0005689 EFO:0000276 @@ -104101,6 +104720,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nodus atrioventricularis UBERON:0002352 + @@ -104221,6 +104841,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers[GO]. + EMAPA:35152 FMA:9484 GAID:559 @@ -104244,6 +104865,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon A-V bundle UBERON:0002353 + bundle of His @@ -104448,7 +105070,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9578 GAID:87 MA:0000030 - MESH:A01.673 + MESH:D010388 NCIT:C12767 OpenCyc:Mx4rvVjiTJwpEbGdrcN5Y29ycA SCTID:229765004 @@ -104685,7 +105307,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9584 GAID:18 MA:0000449 - MESH:A01.047.025.600 + MESH:D010537 NCIT:C12770 OpenCyc:Mx4rvjJ72ZwpEbGdrcN5Y29ycA TAO:0005120 @@ -104814,7 +105436,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An meninx - Illu:meninges.jpg + https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg @@ -104916,7 +105538,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362305004 UMLS:C0031869 Wikipedia:Pia_mater - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1463 + neuronames:1463 pia mater of neuraxis pial membrane uberon @@ -104981,7 +105603,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362304000 UMLS:C1510935 Wikipedia:Arachnoid_mater - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1464 + neuronames:1464 arachnoid arachnoid mater of neuraxis arachnoid membrane @@ -105056,7 +105678,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362301008 UMLS:C0013313 Wikipedia:Dura_mater - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1462 + neuronames:1462 dura mater of neuraxis pachymeninges uberon @@ -105146,7 +105768,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9595 GAID:870 MA:0000257 - MESH:A09.246.397.873 + MESH:D014432 NCIT:C12502 SCTID:181180005 UMLS:C0041445 @@ -105354,7 +105976,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An bulbo-urethral gland - Male:anatomy.png + https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png @@ -105443,6 +106065,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. TODO - FMA treats the gland as part of the prostate - see also FMA:74119. + prostatic BTO:0001129 CALOHA:TS-0828 @@ -105468,6 +106091,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An prostata UBERON:0002367 + @@ -105753,6 +106377,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop. check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland. + Anatomical structure which originates as several paired thickenings on the dorsal side of the pharyngeal pouches and secretes thymosin.[AAO] A thymus develops in all vertebrates from the endodermal epithelium of certain pharyngeal pouches and from the adjacent ectodermal epithelium. In fishes, all the pouches, or the first four, contribute to thymus formation, but in tetrapods, the number is more restricted. In mammals, only the third and fourth are involved, and the contribution of the third is by far the greater.[well established][VHOG] thymic @@ -105768,7 +106393,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:464 MA:0000142 MAT:0000080 - MESH:A06.407.850 + MESH:D013950 MIAA:0000080 NCIT:C12433 OpenCyc:Mx4rvpIympwpEbGdrcN5Y29ycA @@ -105784,13 +106409,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0002370 + thymus - Illu:thymus.jpg + https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg @@ -105870,6 +106496,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The soft tissue that fills the cavities of bones. TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs consider placement of NCIT:C53466 medullary bone + The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG] In adults, marrow in large bones produces new blood cells[Wikipedia:Bone_marrow] AAO:0011007 @@ -105900,6 +106527,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An medullary bone UBERON:0002371 + bone marrow @@ -105985,7 +106613,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9609 GAID:341 MA:0000143 - MESH:A03.867.603.925 + MESH:D014066 NCIT:C12802 OpenCyc:Mx4rvVivrZwpEbGdrcN5Y29ycA UMLS:C0836921 @@ -105993,7 +106621,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1519548 VHOG:0001139 Wikipedia:Tonsil - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=671 + neuronames:671 uberon Mandel UBERON:0002372 @@ -106070,6 +106698,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9610 MA:0000775 MAT:0000291 + MESH:D014066 MIAA:0000291 NCIT:C33250 SCTID:265787001 @@ -106083,7 +106712,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An palatine tonsil - Illu:mouth.jpg + https://upload.wikimedia.org/wikipedia/commons/f/f6/Illu_mouth.jpg @@ -106165,7 +106794,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An metacarpal bone - Metacarpals:numbered-en.svg + https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg @@ -106210,7 +106839,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9615 GAID:110 MA:0001762 - MESH:A02.165.507.211 + MESH:D003413 NCIT:C32400 SCTID:263484006 UMLS:C0010323 @@ -106411,7 +107040,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -106634,6 +107263,81 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + + + + + + Any muscle organ that is part of a perineum [Automatically generated definition]. + EMAPA:36629 + FMA:9623 + MA:0000538 + NCIT:C33300 + UMLS:C0224382 + muscle of perineum + muscle organ of perineal region + muscle organ of perineum + perineal region muscle organ + perineum muscle organ + uberon + UBERON:0002379 + perineal muscle + + + + + + + + + + + prolog + + + + + Any muscle organ that is part of a perineum [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0224382 + ncithesaurus:Perineal_Muscle + + + + + muscle organ of perineal region + OBOL:automatic + + + + + muscle organ of perineum + OBOL:automatic + + + + + perineal region muscle organ + OBOL:automatic + + + + + perineum muscle organ + OBOL:automatic + + + + @@ -106660,7 +107364,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pectoralis major - Pectoralis:major.png + https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png @@ -106727,7 +107431,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An rectus abdominis muscle - Rectus:abdominis.png + https://upload.wikimedia.org/wikipedia/commons/9/95/Rectus_abdominis.png @@ -106778,6 +107482,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] @@ -106807,6 +107512,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon Bindegewebe UBERON:0002384 + @@ -107017,8 +107723,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An forelimb zeugopod - Forearm:labeled.png http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg + https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png @@ -107053,7 +107759,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000341 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -107567,7 +108273,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:1186 MA:0002520 MAT:0000055 - MESH:A12.207.630 + MESH:D008196 MIAA:0000055 NCIT:C13252 OpenCyc:Mx4rvpDOU5wpEbGdrcN5Y29ycA @@ -107791,7 +108497,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001145 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.417 http://bgee.unil.ch/ @@ -107998,7 +108704,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9708 GAID:196 MA:0001351 - MESH:A02.835.232.300.710.780 + MESH:D013628 NCIT:C52799 SCTID:182098005 UMLS:C0039277 @@ -108015,7 +108721,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An talus - Subtalar:Joint.PNG + https://upload.wikimedia.org/wikipedia/commons/a/a9/Subtalar_Joint.PNG @@ -108094,6 +108800,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An AAO:0000633 FMA:9710 MA:0001496 + MESH:D055172 NCIT:C33888 OpenCyc:Mx4rv6jKWZwpEbGdrcN5Y29ycA SCTID:272678009 @@ -108552,6 +109259,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. + Each lung is invested by an exceedingly delicate serous membrane, the pleura, which is arranged in the form of a closed invaginated sac. A portion of the serous membrane covers the surface of the lung and dips into the fissures between its lobes; it is called the pulmonary pleura (or visceral pleura). The visceral pleura is attached directly to the lungs[Wikipedia:Visceral_pleura]. FMA treats this as part of the lungs EHDAA2:0002205 @@ -108572,6 +109280,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lung pleura pulmonary pleura UBERON:0002401 + visceral pleura @@ -108664,7 +109373,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9740 GAID:95 MA:0000055 - MESH:A01.911.800.650 + MESH:D035422 NCIT:C12840 OpenCyc:Mx4rwCKAppwpEbGdrcN5Y29ycA SCTID:361999006 @@ -108750,6 +109459,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. + The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG] AAO:0011003 BILA:0000104 @@ -108769,6 +109479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ZFA:0001159 uberon UBERON:0002405 + @@ -109040,7 +109751,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000396 Wikipedia:Autonomic_nervous_system ZFA:0001574 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2054 + neuronames:2054 autonomic division of peripheral nervous system autonomic part of peripheral nervous system divisio autonomica systematis nervosi peripherici @@ -109057,24 +109768,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An autonomic nervous system http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png - - - - FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib - FMA - - - - - UMLS:C0004388 - BIRNLEX:1123 - - - - - UMLS:C0004388 - ncithesaurus:Autonomic_Nervous_System - @@ -109178,6 +109871,24 @@ A continuant cannot be part of an occurrent: use 'participates in'. An DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000) http://bgee.unil.ch/ + + + + FMA splits this into peripheral and nervous parts; GO has ANS directly under NS; PNS is a sib + FMA + + + + + UMLS:C0004388 + BIRNLEX:1123 + + + + + UMLS:C0004388 + ncithesaurus:Autonomic_Nervous_System + @@ -109995,7 +110706,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:422867004 UMLS:C0175202 Wikipedia:Hippocampal_formation - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=177 + neuronames:177 hippocampus (Crosby) hippocampus uberon @@ -110054,7 +110765,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=177 + neuronames:177 BIRNLEX:715 @@ -110117,6 +110828,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures. + Fluid-filled brain cavity. Kimmel et al, 1995.[TAO] Irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.[AAO] The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space[GO][GO:0021592]. @@ -110150,7 +110862,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Fourth_ventricle XAO:0003099 ZFA:0000110 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=621 + neuronames:621 ventricle IV rhombencephalic vesicle uberon @@ -110163,6 +110875,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ventricle of rhombencephalon ventriculus quartus UBERON:0002422 + @@ -110541,7 +111254,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCITA includes clavicle. MA:'limb bone' is actually a bone of limb or girdle - NCIT + NCIT @@ -110633,7 +111346,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001178 Wikipedia:Pars_intermedia ZFA:0001197 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=409 + neuronames:409 intermediate lobe of adenohypophysis intermediate lobe of pituitary pars intermedia @@ -110798,8 +111511,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Pituitary_stalk XAO:0004210 ZFA:0001199 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=405 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=408 + neuronames:405 + neuronames:408 hypophyseal stalk infundibular stalk infundibular stem @@ -110928,13 +111641,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=405 + neuronames:405 BIRNLEX:1248 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=408 + neuronames:408 BIRNLEX:912 @@ -111115,13 +111828,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4277 MA:0000891 MBA:477 - MESH:A08.186.211.730.885.105.487.550 + MESH:D017072 NCIT:C111122 PBA:10080 UMLS:C0162512 Wikipedia:Striatum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=225 ncithesaurus:Striatum + neuronames:225 neostriatum neuraxis striatum striate nucleus @@ -111200,7 +111913,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=225 + neuronames:225 BIRNLEX:1672 @@ -111278,21 +111991,17 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - + - A subdivision of the cytoarchitecturally defined occipital region of cerebral cortex in the human. Defined by the band of Gennari, which gives it the name striate (furrowed) area, it occupies the banks of the calcarine sulcus which are located in the cuneus and the lingual gyrus of the occipital lobe. Cytoarchitecturally it is bounded by the area 18 of Brodmann (human) which surrounds it ( Brodmann-1909 ). In the mouse ( Paxinos-2001 ) and the rat ( Swanson-1998 ) it is located on the dorsolateral surface of the cerebral hemisphere[BrainInfo]. - We explicitly merge two FMA classes here, as BA17 is equivalent to V1. In future these may be separated into functional and cytoarchitecturally defined regions with an overlaps relationship between them - B09-17 + The visual area of the brain that is specialized for processing information about static and moving objects. The primary visual cortex, which is defined by its function or stage in the visual system, is approximately equivalent to the striate cortex, also known as Brodmann area 17, which is defined by its anatomical location. BAMS:17 BAMS:V1 BAMS:VISp - BIRNLEX:1748 BM:Tel-Cx-V1 BTO:0004703 EMAPA:35708 @@ -111302,23 +112011,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:385 NCIT:C97340 NLX:143552 - PBA:10026 - SCTID:384772005 UMLS:C0038446 - UMLS:C1272535 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 - BA17 - Brodmann (1909) area 17 - Brodmann area 17 - Brodmann area 17, striate - area 17 of Brodmann-1909 - b09-17 + neuronames:702 striate cortex uberon - BA17 - Brodmann area 17 V1 - area 17 of Brodmann area striata calcarine cortex nerve X @@ -111332,21 +112029,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0002436 + In some species, parcellations of lobes are not well defined if at all. The primary visual cortex being part of the occiptal lobe hence could refer to it being part of the most posterior region of the mammalian cerebral cortex. primary visual cortex - http://upload.wikimedia.org/wikipedia/commons/7/70/Brodmann_areas_17_18_19.png - - - - - FMA - - - - - - NIFSTD - @@ -111361,22 +112046,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A subdivision of the cytoarchitecturally defined occipital region of cerebral cortex in the human. Defined by the band of Gennari, which gives it the name striate (furrowed) area, it occupies the banks of the calcarine sulcus which are located in the cuneus and the lingual gyrus of the occipital lobe. Cytoarchitecturally it is bounded by the area 18 of Brodmann (human) which surrounds it ( Brodmann-1909 ). In the mouse ( Paxinos-2001 ) and the rat ( Swanson-1998 ) it is located on the dorsolateral surface of the cerebral hemisphere[BrainInfo]. - BrainInfo:2102 - - - - - We explicitly merge two FMA classes here, as BA17 is equivalent to V1. In future these may be separated into functional and cytoarchitecturally defined regions with an overlaps relationship between them - FMA - - - - - B09-17 - BIRNLEX:1748 - NIFSTD:SumsDB_abbrevSource - + The visual area of the brain that is specialized for processing information about static and moving objects. The primary visual cortex, which is defined by its function or stage in the visual system, is approximately equivalent to the striate cortex, also known as Brodmann area 17, which is defined by its anatomical location. + WikipediaVersioned:Visual_cortex&oldid=1069729211 @@ -111387,87 +112058,21 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - UMLS:C1272535 - BIRNLEX:1748 - - - - - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702 + neuronames:702 BIRNLEX:1748 - - - - BA17 - - - - - - Brodmann (1909) area 17 - BIRNLEX:1748 - - - - - Brodmann area 17 - Wikipedia:Visual_cortex - - - - - Brodmann area 17, striate - BIRNLEX:1748 - - - - - area 17 of Brodmann-1909 - BIRNLEX:1748 - - - - - b09-17 - BIRNLEX:1748 - striate cortex FMA:236871 - Wikipedia:Visual_cortex - - - - - BA17 - Wikipedia:Visual_cortex - - - - - BA17 - - - - - - Brodmann area 17 - Wikipedia:Visual_cortex + Wikipedia:Visual_cortex V1 - Wikipedia:Visual_cortex - - - - - area 17 of Brodmann - Wikipedia:Visual_cortex + Wikipedia:Visual_cortex @@ -111509,19 +112114,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An visual area one - Wikipedia:Visual_cortex + Wikipedia:Visual_cortex visual association area - Wikipedia:Visual_cortex + Wikipedia:Visual_cortex visual association cortex - Wikipedia:Visual_cortex + Wikipedia:Visual_cortex @@ -111552,7 +112157,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:361691006 UMLS:C0152295 UMLS:C1284115 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=189 + neuronames:189 cerebral hemisphere white matter cerebral white matter white matter structure of cerebral hemisphere @@ -111597,7 +112202,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=189 + neuronames:189 BIRNLEX:711 @@ -111639,6 +112244,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of two ganglionated neural networks which together form the enteric nervous system. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. + plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses[MP][MP:0010801]. note that FMA uses Meissner's plexus as a synonym, rather than separate class BAMS:myp @@ -111666,6 +112272,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An plexus myentericus submucous plexus UBERON:0002439 + myenteric nerve plexus @@ -111936,6 +112543,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A region of the lens consisting of packed elongated enucleate cells packed with crystallin. + Fibres resembling a ribbon and arranged in very thin plates in the lens. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] (...) the line, or Y, or star sutures common to mammalian lenses, including those of primates. In the case of line or Y sutures, the overlapping of lens fibers in each successive shell is coincident and results in the formation of four or six three-dimensional suture planes that extend from the lens nucleus to the periphery.[well established][VHOG] BTO:0000724 @@ -111959,6 +112567,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lens fibre set of lens fibers UBERON:0002444 + lens fiber @@ -112029,12 +112638,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad]. + patellar EMAPA:35668 FMA:24485 GAID:203 MA:0001374 - MESH:A02.835.232.500.624 + MESH:D010329 NCIT:C33282 SCTID:182083008 UMLS:C0030647 @@ -112045,11 +112655,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An knee cap patella UBERON:0002446 + The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella. patella - Knee:diagram.svg + https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg @@ -112253,6 +112864,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The maternal uterine-derived portion of the placenta. TODO - check mp syn + formed under the influence of progesterone and forms highly-characteristic cells. [Wikipedia:Decidua] BTO:0001360 CALOHA:TS-0193 @@ -112279,6 +112891,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An placenta maternal decidual layer uterine decidua UBERON:0002450 + decidua @@ -112355,7 +112968,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An maternal placenta - GOC:dph + GOC:dph @@ -112380,6 +112993,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The mucous secreting gland associated with the mucuous membrane lining the uterus. + simple or branched tubular BTO:0003433 @@ -112398,6 +113012,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon glandulae uterinae UBERON:0002451 + @@ -112468,7 +113083,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ethmoid sinus - Nnh:front.svg + https://upload.wikimedia.org/wikipedia/commons/f/fb/Nnh_front.svg @@ -113222,6 +113837,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:26981 FMA:62996 MA:0002680 + MESH:D000071041 NCIT:C32538 SCTID:362127004 UMLS:C0227176 @@ -113408,7 +114024,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An autopodial limb segment - MA:th + MA:th @@ -113471,7 +114087,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epipodium - MA:th + MA:th @@ -113483,13 +114099,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An zeugopod limb segment - MA:th + MA:th zeugopodial limb segment - MA:th + MA:th @@ -113536,7 +114152,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An propodium - MA:th + MA:th @@ -113548,7 +114164,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stylopodial limb segment - MA:th + MA:th @@ -113574,7 +114190,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:67930 MA:0002721 SCTID:360567002 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1559 + neuronames:1559 uberon commissure of cerebrum inter-hemispheric commissure @@ -113621,7 +114237,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:752 UMLS:C0228514 Wikipedia:Cerebellar_peduncle - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 + neuronames:224 cerebellar peduncles cerebellar peduncles and decussations cerebellar peduncles set @@ -113673,7 +114289,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 + neuronames:224 BIRNLEX:970 @@ -114059,6 +114675,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow. + BTO:0001700 CALOHA:TS-0110 EMAPA:35873 @@ -114078,6 +114695,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An substantia trabecularis ossium trabecular substance UBERON:0002483 + one of the two types of osseous tissue that form bones. Compared to compact bone, which is the other type of osseous tissue, it has a higher surface area but is less dense, softer, weaker, and less stiff. It typically occurs at the ends of long bones, proximal to joints and within the interior of vertebrae. Cancellous bone is highly vascular and frequently contains red bone marrow where hematopoiesis, which is the production of blood cells, occurs. The primary anatomical and functional unit of cancellous bone is the trabecula. @@ -114178,7 +114796,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -114289,7 +114907,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glottis - Arytenoid:cartilage.png + https://upload.wikimedia.org/wikipedia/commons/3/32/Arytenoid_cartilage.png @@ -114330,7 +114948,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The central hollow space of a tooth. FMA:55660 MA:0002792 - MESH:A14.254.900.265 + MESH:D003786 SCTID:362105008 Wikipedia:Tooth_cavity cavitas dentis @@ -114471,7 +115089,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An coronal suture - Gray188-Coronal:suture.png + https://upload.wikimedia.org/wikipedia/commons/a/ae/Gray188-Coronal_suture.png @@ -114526,8 +115144,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An frontal suture - Frontal:suture.png http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png + https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png @@ -114589,7 +115207,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lambdoid suture - Gray188-Lambdoid:suture.png + https://upload.wikimedia.org/wikipedia/commons/3/3d/Gray188-Lambdoid_suture.png @@ -114677,13 +115295,16 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The branch of the internal iliac artery that supplies the uterus and the upper part of the vagina. + FMA:18829 MA:0002799 + MESH:D055988 SCTID:244300003 Wikipedia:Uterine_artery uberon arteria uterina UBERON:0002493 + uterine artery @@ -114742,7 +115363,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An papillary muscle of heart - Papillary:muscles.png + https://upload.wikimedia.org/wikipedia/commons/8/87/Papillary_muscles.png @@ -115206,7 +115827,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An zygomatic arch - Gray188-Sphenozygomatic:suture.png + https://upload.wikimedia.org/wikipedia/commons/f/f4/Gray188-Sphenozygomatic_suture.png @@ -115447,11 +116068,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents. + FMA:52312 MA:0002824 SCTID:149380004 uberon UBERON:0002505 + spiral modiolar artery @@ -115476,6 +116099,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium that is part of a iris [Automatically generated definition]. + EMAPA:35447 FMA:58517 MA:0002826 @@ -115489,6 +116113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon iris pigmented epithelium UBERON:0002506 + iris epithelium @@ -115612,6 +116237,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The visceral glands that are associated with the branches of the celiac artery, including the gastric, hepatic, and pancreaticolienal (splenic) lymph nodes. + FMA:12792 MA:0002828 NCIT:C65166 @@ -115629,6 +116255,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An jPS no. 9 node no. 9 celiac lymph node UBERON:0002508 + celiac lymph node @@ -115698,6 +116325,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group. + BTO:0000767 EMAPA:35561 FMA:12795 @@ -115709,6 +116337,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon nodi lymphoidei mesenterici UBERON:0002509 + mesenteric lymph node @@ -115771,7 +116400,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0001739 anterior cranial fontanel is 'Fontanel that is located between the contralateral frontals and anterior to the epiphyseal bar' - TAO + TAO @@ -115930,6 +116559,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A transient endocrine gland that develops from the postovulatory or atretic follicles and secretes progesterone; it is thought to be related to egg retention[PMID]. + maintains the endometrium in mammals[WP]. A corpus luteum is known in hagfish (100), Squalus (101), and salamander (100) but not lamprey (102). There are no data for Branchiostoma and Ciona, and given that they are multiple spawners, there is no a priori reason to conclude that they lack a corpus luteum BTO:0000292 CALOHA:TS-0181 @@ -115948,6 +116578,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon luteal gland UBERON:0002512 + corpus luteum @@ -116209,7 +116840,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An periosteum - Bone:growth.png + https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png @@ -116445,7 +117076,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane). ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0002894 @@ -116562,7 +117193,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm @@ -116648,7 +117279,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An May be composed of smooth muscle and elastic tissue tunica media - Illu:artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg @@ -116710,7 +117341,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0002523 tunica intima - Illu:artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg @@ -116861,7 +117492,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An organ that functions as a secretory or excretory organ. glandular - UBERON:MIAA_0000021 AAO:0000212 AEO:0000096 BTO:0000522 @@ -117225,7 +117855,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:293015 GAID:1292 MAT:0000242 - MESH:A16.254.160 + MESH:D001934 MIAA:0000242 NCIT:C34249 SCTID:308766004 @@ -117546,6 +118176,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000707 FBbt:00001727 HAO:0000459 + MESH:D007814 OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA TAO:0002048 Wikipedia:Larva @@ -117701,10 +118332,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62027 HBA:12902 HBA:4570 - MESH:A08.186.211.730.385.357.342 + MESH:D007032 UMLS:C0020653 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2381 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=376 + neuronames:2381 + neuronames:376 anterior hypothalamic area chiasmal zone uberon @@ -117729,7 +118360,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=376 + neuronames:376 BIRNLEX:1005 @@ -117834,7 +118465,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:706 UMLS:C0175359 Wikipedia:Olivary_pretectal_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472 + neuronames:472 nucleus praetectalis olivaris olivary nucleus of superior colliculus pretectal olivary nucleus @@ -117908,7 +118539,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=472 + neuronames:472 BIRNLEX:1037 @@ -118002,7 +118633,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:361541001 UMLS:C0228427 Wikipedia:Basilar_part_of_pons - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=616 + neuronames:616 basal portion of pons base of pons basilar part of pons @@ -118035,7 +118666,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=616 + neuronames:616 BIRNLEX:1043 @@ -118123,6 +118754,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Component of the parietal lobe. The appearance and disappearance of the central sulcus were the rostral and caudal boundaries of the postcentral gyrus respectively. The medial and lateral boundaries were the lateral bank of the precentral gyrus and the lateral fissure and/or the medial bank of the superior parietal gyrus respectively (Christine Fennema-Notestine). + BAMS:PoG BIRNLEX:1070 BTO:0004354 @@ -118134,7 +118766,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279167001 UMLS:C0152302 Wikipedia:Postcentral_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=105 + neuronames:105 gyrus postcentralis postcentral convolution posterior central gyrus @@ -118145,10 +118777,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An somatosensory cortex UBERON:0002581 + postcentral gyrus - Postcentral:gyrus.png + https://upload.wikimedia.org/wikipedia/commons/6/66/Postcentral_gyrus.png @@ -118171,7 +118804,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=105 + neuronames:105 BIRNLEX:1070 @@ -118249,7 +118882,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369091005 UMLS:C0152402 Wikipedia:Lateral_corticospinal_tract - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=801 + neuronames:801 corticospinal tract, crossed crossed pyramidal tract lateral pyramidal tract @@ -118317,7 +118950,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=801 + neuronames:801 BIRNLEX:1095 @@ -118391,6 +119024,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem. + BAMS:LL BAMS:Limbic_lobe BIRNLEX:1128 @@ -118398,10 +119032,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An DHBA:12155 FMA:72719 HBA:4219 + MESH:D065726 SCTID:279215006 UMLS:C0458337 Wikipedia:Limbic_lobe - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=834 + neuronames:834 fornicate gyrus grande lobe limbique of Broca limbic lobe (carpenter) @@ -118411,6 +119046,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gyrus fornicatus lobus limbicus UBERON:0002600 + limbic lobe @@ -118437,7 +119073,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=834 + neuronames:834 BIRNLEX:1128 @@ -118493,7 +119129,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279222003 UMLS:C0175488 Wikipedia:Emboliform_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=688 + neuronames:688 anterior interposed nucleus anterior interpositus nucleus cerebellar emboliform nucleus @@ -118534,7 +119170,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=688 + neuronames:688 BIRNLEX:1135 @@ -118621,7 +119257,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cluster of neurites that is part of a nervous system and forms a network of dendrites and axons where synapses are present and in which neuronal somata do not occur. - PMID:21062451 + PMID:21062451 @@ -118674,7 +119310,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:607 UMLS:C0152411 Wikipedia:Cochlear_nuclei - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=720 + neuronames:720 cochlear nuclei uberon nuclei cochleares @@ -118758,7 +119394,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=720 + neuronames:720 BIRNLEX:1151 @@ -118798,7 +119434,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279223008 UMLS:C0175489 Wikipedia:Globose_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=689 + neuronames:689 globose nucleus medial interposed nucleus medial interpositus (globose) nucleus @@ -118856,7 +119492,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=689 + neuronames:689 BIRNLEX:1158 @@ -119051,7 +119687,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0001355 Wikipedia:Trigeminal_motor_nucleus ZFA:0001365 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=559 + neuronames:559 motor nucleus V motor nucleus of cranial nerve v motor nucleus of trigeminal nerve @@ -119178,7 +119814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=559 + neuronames:559 BIRNLEX:1222 @@ -119302,11 +119938,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:642 HBA:12903 MBA:88 - MESH:A08.186.211.730.385.357.342.063 + MESH:D007025 SCTID:369133009 UMLS:C0020653 Wikipedia:Anterior_hypothalamic_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=386 + neuronames:386 anterior hypothalamic nucleus area hypothalamica rostralis fundamental gray substance @@ -119378,7 +120014,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=386 + neuronames:386 BIRNLEX:1226 @@ -119484,10 +120120,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:637 HBA:13002 MA:0002978 - MESH:A08.186.211.577.750.800 + MESH:D012686 UMLS:C0036687 Wikipedia:Septal_nuclei - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=259 + neuronames:259 parolfactory nuclei septal nuclei septal nucleus @@ -119589,7 +120225,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4303 MBA:242 UMLS:C0175232 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=261 + neuronames:261 lateral parolfactory nucleus lateral septal nucleus (cajal) lateral septum @@ -119628,7 +120264,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=261 + neuronames:261 BIRNLEX:1321 @@ -119698,7 +120334,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33706 SCTID:279185008 UMLS:C0228214 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=108 + neuronames:108 anterior part of inferior parietal lobule inferior parietal lobule (krieg) uberon @@ -119733,7 +120369,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=108 + neuronames:108 BIRNLEX:1381 @@ -119769,6 +120405,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Component of the frontal lobe. The appearance and disappearance of the central sulcus is the rostral and caudal boundaries of the precentral gyrus respectively. The medial boundary is specific frontal gyri (superior, middle and inferior) whereas the lateral boundary is the medial bank of the central sulcus (Christine Fennema-Notestine). + BAMS:PrG BIRNLEX:1455 DHBA:12114 @@ -119778,7 +120415,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33393 UMLS:C0152299 Wikipedia:Precentral_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=89 + neuronames:89 precentral convolution prerolandic gyrus uberon @@ -119788,6 +120425,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An motor cortex (Noback) UBERON:0002703 + precentral gyrus @@ -119814,7 +120452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=89 + neuronames:89 BIRNLEX:1455 @@ -119879,7 +120517,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:1008 SCTID:361550004 Wikipedia:Metathalamus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=351 + neuronames:351 geniculate group of the dorsal thalamus geniculate thalamic group nuclei metathalami @@ -119927,7 +120565,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=351 + neuronames:351 BIRNLEX:1461 @@ -119986,7 +120624,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:571 SCTID:279163002 Wikipedia:Midline_nuclear_group - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=306 + neuronames:306 median nuclei of thalamus midline nuclear group midline nuclear group of thalamus @@ -120015,7 +120653,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=306 + neuronames:306 BIRNLEX:1462 @@ -120125,6 +120763,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract. + UBERON:0004095 pyramidal tract BAMS:P @@ -120143,8 +120782,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362325000 UMLS:C0034229 Wikipedia:Corticospinal_tract - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800 + neuronames:1320 + neuronames:800 corticospinal fibers fasciculus cerebro-spinalis fasciculus pyramidalis @@ -120155,6 +120794,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tractus pyramidalis uberon UBERON:0002707 + corticospinal tract @@ -120179,7 +120819,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pyramidal tract BIRNLEX:1464 MP:0002878 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320 + neuronames:1320 @@ -120191,7 +120831,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800 + neuronames:800 BIRNLEX:1464 @@ -120295,13 +120935,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:636 MA:0003117 MBA:909 - MESH:A08.186.211.577.710.225 + MESH:D018728 NCIT:C97338 PBA:294022158 SCTID:369099007 UMLS:C0175196 Wikipedia:Entorhinal_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=168 + neuronames:168 entorhinal area uberon Brodmann's area 28 @@ -120378,7 +121018,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=168 + neuronames:168 BIRNLEX:1508 @@ -120445,10 +121085,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GAID:660 MA:0000871 MBA:51 - MESH:A08.186.211.730.385.826.701.460 + MESH:D020646 SCTID:279159009 Wikipedia:Intralaminar_thalamic_nuclei - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=317 + neuronames:317 intralaminar nuclear complex intralaminar nuclear group intralaminar nuclear group of thalamus @@ -120501,7 +121141,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=317 + neuronames:317 BIRNLEX:1530 @@ -120592,6 +121232,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert. + BAMS:Basal_forebrain BIRNLEX:1560 BM:Tel-BF @@ -120600,13 +121241,15 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35164 FMA:77700 HBA:4300 + MESH:D066187 PBA:128012976 Wikipedia:Basal_forebrain - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1997 + neuronames:1997 uberon basal forebrain area pars basalis telencephali UBERON:0002743 + basal forebrain http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png @@ -120631,7 +121274,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1997 + neuronames:1997 BIRNLEX:1560 @@ -120722,7 +121365,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369058001 UMLS:C0011128 Wikipedia:Decussation_of_pyramids - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=799 + neuronames:799 corticospinal decussation decussatio pyramidum decussatio pyramidum medullae oblongatae @@ -120782,7 +121425,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=799 + neuronames:799 BIRNLEX:1594 @@ -120897,7 +121540,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369092003 UMLS:C0152403 Wikipedia:Ventral_corticospinal_tract - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=802 + neuronames:802 anterior corticospinal tract anterior pyramidal tract anterior tract of turck @@ -120954,7 +121597,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=802 + neuronames:802 BIRNLEX:1618 @@ -121075,6 +121718,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the ssuperior temporal sulcus. The caudal boundary is the cauday portion of the superior temporal gyrus (posterior to becoming continuous with the supramarginal gyrus). The medial boundary is the lateral fissure (and when present the supramarginal gyrus), and the lateral boundary is the superior temporal suclus (Christine Fennema-Notestine). + BAMS:STG BIRNLEX:1648 BM:Tel-STG @@ -121086,13 +121730,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362345008 UMLS:C0152309 Wikipedia:Superior_temporal_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=136 ncithesaurus:Superior_Temporal_Gyrus + neuronames:136 gyrus temporalis superior uberon gyrus temporalis superior UBERON:0002769 + superior temporal gyrus @@ -121113,7 +121758,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=136 + neuronames:136 BIRNLEX:1648 @@ -121150,10 +121795,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62029 GAID:651 HBA:4665 - MESH:A08.186.211.730.385.357.362 + MESH:D007034 UMLS:C0020670 Wikipedia:Mammillary_process - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=411 + neuronames:411 mammillary level of hypothalamus mammillary region posterior hypothalamus @@ -121186,7 +121831,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=411 + neuronames:411 BIRNLEX:1651 @@ -121246,7 +121891,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0228333 Wikipedia:Ventral_nuclear_group ZFA:0005576 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=333 + neuronames:333 dorsal thalamus, ventral group nuclei ventrales thalami ventral group of dorsal thalamus @@ -121311,7 +121956,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=333 + neuronames:333 BIRNLEX:1669 @@ -121416,7 +122061,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0446706 VHOG:0000682 Wikipedia:Scarpa%27s_ganglion - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=495 + neuronames:495 Scarpa's ganglion vestibular part of vestibulocochlear ganglion vestibulocochlear VIII ganglion vestibular component @@ -121462,7 +122107,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=495 + neuronames:495 BIRNLEX:2549 @@ -121601,7 +122246,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000696 XAO:0004142 ZFA:0000588 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=496 + neuronames:496 acoustic ganglion VIII acoustico-vestibular VIII ganglion auditory ganglion @@ -121710,7 +122355,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=496 + neuronames:496 BIRNLEX:2564 @@ -121932,8 +122577,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0228802 VHOG:0001358 Wikipedia:Hypoglossal_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 ncithesaurus:Nucleus_of_the_Hypoglossal_Nerve + neuronames:757 hypoglossal XII nucleus hypoglossal nerve nucleus hypoglossal nucleus @@ -122024,7 +122669,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 + neuronames:757 BIRNLEX:2644 @@ -122113,10 +122758,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:276600 HBA:265504406 MA:0000193 + MESH:D066194 UMLS:C0162434 VHOG:0000325 Wikipedia:Olfactory_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2275 + neuronames:2275 uberon archaeocortex archeocortex @@ -122136,7 +122782,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -122173,7 +122819,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An (In mammals) Odorant detection is mediated by millions of olfactory sensory neurons located in the olfactory epithelium lining the nasal cavity. These neurons transmit sensory signals to the olfactory bulb of the brain, which in turn sends signals to the olfactory cortex.[well established][VHOG] 2012-09-17 VHOG:0000325 - VHOG + VHOG DOI:10.1111/j.1753-4887.2004.tb00097.x Buck LB, Olfactory receptors and odor coding in mammals. Nutrition Reviews (2008) http://bgee.unil.ch/ @@ -122224,7 +122870,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:47947006 UMLS:C0228152 Wikipedia:Chiasmatic_cistern - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=30 + neuronames:30 cisterna chiasmatica cisterna chiasmatis uberon @@ -122264,7 +122910,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=30 + neuronames:30 BIRNLEX:4003 @@ -122337,7 +122983,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA. - GO + GO https://github.com/obophenotype/mouse-anatomy-ontology/issues/58 @@ -122449,7 +123095,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:1143 NCIT:C49138 UMLS:C1708253 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=363 + neuronames:363 cerebellar granular layer cerebellar granule cell layer cerebellar granule layer @@ -122485,7 +123131,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=363 + neuronames:363 BIRNLEX:779 @@ -122546,7 +123192,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:62164 HBA:12929 UMLS:C0175263 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=318 + neuronames:318 anterior group of intralaminar nuclei nuclei intralaminares rostrales rostral group of intralaminar nuclei @@ -122584,7 +123230,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=318 + neuronames:318 BIRNLEX:794 @@ -122631,6 +123277,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the convolutions on the medial surface of the cerebral hemisphere. It surrounds the rostral part of the brain and interhemispheric commissure and forms part of the limbic system. (MSH) One of three essential structures comprising the limbic lobe, the other two being the hippocampus and parahippocampal gyrus. (CSP). + BAMS:CG BAMS:CgG BIRNLEX:798 @@ -122643,7 +123290,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279208003 UMLS:C0018427 Wikipedia:Cingulate_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=159 + neuronames:159 cingulate area cingulate region falciform lobe @@ -122652,6 +123299,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cingular gyrus gyri cinguli UBERON:0002967 + cingulate gyrus @@ -122678,7 +123326,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=159 + neuronames:159 BIRNLEX:798 @@ -122744,6 +123392,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Component of the temporal lobe on the mesial surface, posterior to the entorhinal cortex. The rostral and caudal boundaries are the posterior end of the netorhinal cortex and the caudal portion of the hippocampus, respectively. The medial boudnary is designated as the medial aspect off the temporal lobe and the lateral boundary is the collateral sulcus (Christine Fennema-Notestine). + BAMS:PHG BIRNLEX:807 BTO:0004380 @@ -122753,12 +123402,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:61918 GAID:634 HBA:4242 - MESH:A08.186.211.577.710 + MESH:D020534 NCIT:C33262 SCTID:279205000 UMLS:C0228249 Wikipedia:Parahippocampal_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=164 + neuronames:164 hippocampal gyrus uberon gyrus hippocampi @@ -122766,6 +123415,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gyrus parahippocampi hippocampal convolution UBERON:0002973 + parahippocampal gyrus http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG @@ -122825,7 +123475,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=164 + neuronames:164 BIRNLEX:807 @@ -122883,7 +123533,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0228469 UMLS:C1289474 UMLS:C1709064 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=366 + neuronames:366 cerebellar molecular layer cerebellum molecular cell layer cerebellum molecular layer @@ -122922,7 +123572,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=366 + neuronames:366 BIRNLEX:810 @@ -122972,7 +123622,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0228469 UMLS:C1289475 UMLS:C1709776 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=365 + neuronames:365 Purkinje cell layer cerebellar Purkinje cell layer cerebellum Purkinje cell layer @@ -123021,7 +123671,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=365 + neuronames:365 BIRNLEX:818 @@ -123041,41 +123691,41 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nuclei reticulares (thalami) - NeuroNames:365 + NeuroNames:365 nucleus reticularis - NeuroNames:365 + NeuroNames:365 nucleus reticulatus (thalami) - NeuroNames:365 + NeuroNames:365 nucleus thalamicus reticularis - NeuroNames:365 + NeuroNames:365 reticular nucleus thalamus (Arnold) - NeuroNames:365 + NeuroNames:365 reticulatum thalami (Hassler) - NeuroNames:365 + NeuroNames:365 @@ -123141,7 +123791,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:369139008 UMLS:C0228375 UMLS:C1289566 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=424 + neuronames:424 uberon fasciculus mamillothalamicus (hypothalami) mammillothalamic tract of the hypothalamus @@ -123184,7 +123834,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=424 + neuronames:424 BIRNLEX:855 @@ -123228,7 +123878,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0175442 Wikipedia:Facial_motor_nucleus ZFA:0000206 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=586 + neuronames:586 branchiomotor nucleus of facial nerve facial motor nucleus facial nerve motor nucleus @@ -123318,7 +123968,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=586 + neuronames:586 BIRNLEX:903 @@ -123422,7 +124072,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0002965 SCTID:279361008 Wikipedia:Flocculonodular_lobe - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=679 + neuronames:679 cerebellum flocculonodular lobe flocculonodular lobe flocculonodular lobe of cerebellum @@ -123507,7 +124157,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:920 SCTID:279383007 Wikipedia:Central_lobule - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=658 + neuronames:658 central lobule of cerebellum central lobule of cerebellum [II and III] lobulus centralis cerebelli [ii et iii] @@ -123604,16 +124254,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). + involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum] BAMS:PTg BIRNLEX:923 DHBA:12416 FMA:71108 HBA:9135 + MESH:D065821 SCTID:362401009 UMLS:C0228426 Wikipedia:Pontine_tegmentum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=557 + neuronames:557 dorsal pons dorsal portion of pons tegmental portion of pons @@ -123624,9 +124276,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pars posterior pontis tegmentum pontis UBERON:0003023 + pontine tegmentum - Brainstem:Abducens.png + https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png @@ -123643,7 +124296,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=557 + neuronames:557 BIRNLEX:923 @@ -123831,7 +124484,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37404 FMA:61963 MBA:900 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=206 + neuronames:206 anterior commissure pars anterior anterior commissure, anterior part anterior part of anterior commissure @@ -123980,7 +124633,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BIRNLEX:974 FMA:72501 UMLS:C0175452 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=607 + neuronames:607 central part of trigeminal nerve trigeminal nerve fibers trigeminal nerve tract @@ -124004,7 +124657,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=607 + neuronames:607 BIRNLEX:974 @@ -124054,7 +124707,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:61964 MBA:908 UMLS:C0175210 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=207 + neuronames:207 anterior commissure pars posterior anterior commissure temporal limb anterior commissure, posterior part @@ -124387,7 +125040,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - @@ -124413,7 +125065,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000649 XAO:0000016 ZFA:0000042 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2076 + neuronames:2076 MHB mid-hindbrain boundary mid-hindbrain junction @@ -124523,7 +125175,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000303 ZFA:0001436 ZFA:0007058 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1371 + neuronames:1371 roof plate neural tube roof plate neural tube region roofplate @@ -125159,7 +125811,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16075 FMA:293116 GAID:1312 - MESH:A16.254.650 + MESH:D020897 NCIT:C34266 SCTID:361464001 TAO:0000071 @@ -126147,7 +126799,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium. - GO + GO @@ -126431,7 +127083,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:1590 EMAPA:16577 GAID:1315 - MESH:A16.254.940 + MESH:D014928 NCIT:C26469 SCTID:308800003 TAO:0000546 @@ -126566,6 +127218,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:902 EMAPA:35593 FMA:293879 + MESH:D054258 NCIT:C34225 RETIRED_EHDAA2:0001252 TAO:0000132 @@ -126574,7 +127227,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Wikipedia:Neural_plate XAO:0000249 ZFA:0000132 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1362 + neuronames:1362 uberon lamina neuralis presumptive central nervous system @@ -126583,7 +127236,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An neural plate - Neural:Crest.png + https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png @@ -126860,7 +127513,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -127122,7 +127775,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2 - VHOG + VHOG @@ -127146,7 +127799,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG http://bgee.unil.ch/ @@ -127155,7 +127808,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) http://bgee.unil.ch/ @@ -127261,7 +127914,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -127784,7 +128437,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -128297,12 +128950,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. consider obsoleting. See issue/1305 Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] @@ -128700,7 +129347,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000708 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -129989,7 +130636,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - The outermost extraembryonic membrane. + The outermost extraembryonic membrane of amniotes. + The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG] The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252]. Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG] @@ -130005,7 +130653,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100121 FMA:80224 GAID:1299 - MESH:A16.254.403.473 + MESH:D002823 NCIT:C34122 NCIT:C34124 UMLS:C0008503 @@ -130022,8 +130670,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An chorionic sac UBERON:0003124 + + This term refers to the amniote structure. It is distinct from the concept of chorion in insects chorion membrane http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png @@ -130041,9 +130691,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - The outermost extraembryonic membrane. + The outermost extraembryonic membrane of amniotes. MESH:A10.615.284.473 MP:0002836 + http://orcid.org/0000-0002-6601-2165 + https://github.com/geneontology/go-ontology/issues/22603 @@ -130128,6 +130780,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + An elongated tube which carries air to and from the lungs.[AAO] The respiratory tube between the larynx and the bronchi. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] In primitive fishes and most tetrapods, the lungs of adults are usually paired. They lie ventral to the digestive tract and are connected to the outside environment through the trachea.[well established][VHOG] @@ -130162,6 +130815,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tracheal tubule UBERON:0003126 + @@ -130456,7 +131110,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO uses genitalia for the singular organ - GO + GO @@ -130733,7 +131387,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912). - FBC:auto_generated_definition + FBC:auto_generated_definition @@ -130918,7 +131572,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hard palate - Illu:mouth.jpg + https://upload.wikimedia.org/wikipedia/commons/f/f6/Illu_mouth.jpg @@ -132070,7 +132724,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mesentery that surrounds the heart. - MA:th + MA:th @@ -132530,7 +133184,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000300 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -132623,7 +133277,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000782 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -134046,6 +134700,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + UBERON:0004244 BTO:0001391 EMAPA:19192 @@ -134057,6 +134712,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tracheal smooth muscle uberon UBERON:0003387 + smooth muscle of trachea @@ -135606,6 +136262,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. EMAPA:37303 MA:0000592 + MESH:D050280 OpenCyc:Mx4rwKTXoJwpEbGdrcN5Y29ycA arm bone organ bone of arm @@ -135719,6 +136376,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35924 MA:0001482 MA:0003159 + MESH:D005147 NCIT:C63706 SCTID:181799005 UMLS:C0015455 @@ -136166,6 +136824,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + EMAPA:37429 FMA:49567 MA:0001916 @@ -136178,6 +136837,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ramus labialis inferior arteriae facialis uberon UBERON:0003471 + artery of lower lip @@ -139078,6 +139738,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The ring-shaped cartilaginous structures that support the trachea. check whether to classify as part of splanchoncranium + in mammals the rings are incomplete, in avians the rings are complete. EMAPA:18699 EMAPA:35875 @@ -139101,6 +139762,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An trachea ring tracheal ring UBERON:0003604 + trachea cartilage http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png @@ -140437,7 +141099,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003622 manual digit 2 - Index:finger.JPG + https://upload.wikimedia.org/wikipedia/commons/d/d5/Index_finger.JPG @@ -140555,7 +141217,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003623 manual digit 3 - Middle:finger.jpg + https://upload.wikimedia.org/wikipedia/commons/f/fd/Middle_finger.jpg @@ -140684,7 +141346,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003624 manual digit 4 - Ring:finger.JPG + https://upload.wikimedia.org/wikipedia/commons/1/14/Ring_finger.JPG @@ -144667,7 +145329,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32897 FMA:55638 MA:0000350 - MESH:A14.254.860.525 + MESH:D008963 NCIT:C33136 SCTID:362115002 UMLS:C0026367 @@ -144771,7 +145433,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An basipodium bone - MA:th + MA:th @@ -145218,7 +145880,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An AAO:0000126 FMA:75150 GAID:1249 - MESH:A14.254 + MESH:D003817 NCIT:C13072 OpenCyc:Mx4rvVi65JwpEbGdrcN5Y29ycA SCTID:245543004 @@ -145306,7 +145968,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An canine FMA:55636 GAID:1262 - MESH:A14.254.860.200 + MESH:D003481 NCIT:C32258 SCTID:420817000 SCTID:88719004 @@ -145330,7 +145992,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003674 cuspid - Azawakh:K9.jpg + https://upload.wikimedia.org/wikipedia/commons/5/57/Azawakh_K9.jpg @@ -145460,7 +146122,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the tooth covered by enamel. FMA:55623 GAID:1275 - MESH:A14.254.900.710 + MESH:D019228 NCIT:C32375 SCTID:362106009 UMLS:C0226993 @@ -145529,7 +146191,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37975 FMA:55624 GAID:1280 - MESH:A14.254.900.750 + MESH:D014092 SCTID:245728004 radix corona root of tooth @@ -145833,7 +146495,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture. FMA:71385 - ISBN:3110148986 + ISBN:3110148986 Wikipedia:Suture_(joint) @@ -145930,7 +146592,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100084 FMA:14650 GAID:23 - MESH:A01.047.025.600.573 + MESH:D009852 NCIT:C33209 SCTID:362710002 UMLS:C0028977 @@ -146021,7 +146683,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An the AAO class 'sacrum' is deliberately placed under 'sacral vertebra' rather than here - AAO + AAO @@ -146154,7 +146816,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:35246 GAID:255 MA:0000453 - MESH:A02.835.583.345.512 + MESH:D008662 NCIT:C33106 OpenCyc:Mx4rwNt8wJwpEbGdrcN5Y29ycA SCTID:280995004 @@ -146256,7 +146918,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:10429 FMA:259054 GAID:26 - MESH:A01.047.050 + MESH:D034861 NCIT:C77608 SCTID:181613000 UMLS:C0836916 @@ -146685,7 +147347,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37881 FMA:19928 GAID:28 - MESH:A01.047.412 + MESH:D007264 NCIT:C93029 SCTID:243966008 UMLS:C0021445 @@ -147100,7 +147762,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An OpenCyc:Mx4rwSrCwJwpEbGdrcN5Y29ycA SCTID:362047009 Wikipedia:Circle_of_Willis - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1468 + neuronames:1468 arterial circle of Willis cerebral arterial circle uberon @@ -147157,84 +147819,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - - - - - - Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. - One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] - FMA definition includes vasculature - AAO:0000325 - AEO:0000123 - EHDAA2:0003123 - FMA:9642 - GAID:609 - MESH:D009417 - NCIT:C13052 - OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ - SCTID:91728009 - UMLS:C0027757 - nerve tissue - nervous tissue - portion of neural tissue - uberon - UBERON:0003714 - neural tissue - - - - - Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. - FMA:9642 - - - - - One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] - 2012-06-20 - AAO:0000325 - AAO - AAO:LAP - - - - - FMA definition includes vasculature - FMA - - - - - UMLS:C0027757 - ncithesaurus:Nervous_Tissue - - - - - nerve tissue - FMA:9642 - - - - - nervous tissue - FMA:9642 - - - - - portion of neural tissue - FMA:9642 - - - - @@ -147295,7 +147879,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The sensory organs in muscle that are involved in the stretch reflex. FMA:83607 GAID:819 - MESH:A08.800.550.700.500.500 + MESH:D009470 NCIT:C13824 SCTID:12945004 UMLS:C0027871 @@ -147359,8 +147943,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83609 GAID:817 GAID:820 - MESH:A08.800.550.700.500.300 - MESH:A08.800.550.700.500.700 + MESH:D010141 NCIT:C13172 NIF_Subcellular:FMA_83604 SCTID:37419002 @@ -147573,7 +148156,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0042598 VHOG:0001181 Wikipedia:Vestibular_nerve - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1389 + neuronames:1389 vestibular root of acoustic nerve vestibular root of eighth cranial nerve vestibulocochlear VIII nerve vestibular component @@ -147657,6 +148240,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle. + BAMS:cep FMA:5904 GAID:847 @@ -147670,6 +148254,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon plexus cervicalis UBERON:0003725 + cervical nerve plexus http://upload.wikimedia.org/wikipedia/commons/2/20/Gray784.png @@ -147727,7 +148312,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9826 GAID:94 MA:0003075 - MESH:A01.911.800.500 + MESH:D008482 NCIT:C12748 OpenCyc:Mx4rv2OKJ5wpEbGdrcN5Y29ycA SCTID:181217005 @@ -148109,7 +148694,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000343 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -148134,7 +148719,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An forelimb stylopodial element - MA:th + MA:th @@ -148269,7 +148854,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000348 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -149690,6 +150275,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium that is part of a thymus, forming a supporting framework[MP,modified]. + BTO:0001836 CALOHA:TS-1040 EHDAA2:0002019 @@ -149710,6 +150296,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus gland epithelium uberon UBERON:0003846 + thymus epithelium @@ -151114,11 +151701,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12892 MA:0000950 MBA:382 + MESH:D056547 NCIT:C32246 PBA:10058 UMLS:C0694598 Wikipedia:Region_I_of_hippocampus_proper - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=183 + neuronames:183 CA1 CA1 field CA1 field of Ammon's horn @@ -151179,7 +151767,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=183 + neuronames:183 BIRNLEX:1197 @@ -151291,11 +151879,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12893 MA:0000951 MBA:423 + MESH:D056651 NCIT:C32247 PBA:10063 UMLS:C0694599 Wikipedia:Region_II_of_hippocampus_proper - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=184 + neuronames:184 CA2 CA2 field CA2 field of Ammon's horn @@ -151353,7 +151942,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=184 + neuronames:184 BIRNLEX:1362 @@ -151447,11 +152036,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12894 MA:0000952 MBA:463 + MESH:D056654 NCIT:C32248 PBA:10068 UMLS:C0694600 Wikipedia:Region_III_of_hippocampus_proper - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=185 + neuronames:185 CA3 CA3 field CA3 field of Ammon's horn @@ -151514,7 +152104,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=185 + neuronames:185 BIRNLEX:1204 @@ -151633,7 +152223,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PBA:10074 UMLS:C2328406 Wikipedia:Region_IV_of_hippocampus_proper - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=181 + neuronames:181 CA4 CA4 field CA4 field of Ammon's horn @@ -151705,6 +152295,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A mesentery that is part of a uterus [Automatically generated definition]. + EMAPA:35562 FMA:19816 MA:0002931 @@ -151713,6 +152304,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon mesentery of uterus UBERON:0003885 + mesometrium @@ -151743,6 +152335,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical cavity that has the potential to develop into a coelemic cavity lumen. + future coelomic cavity lumen uberon body cavity precursor UBERON:0003886 @@ -151960,6 +152553,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Initial section of the oviduct through which the ova pass from the ovary to the uterus. + Homologous to appendix testis salpinges salpinx @@ -151987,6 +152581,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tuba uterina UBERON:0003889 + fallopian tube @@ -152074,7 +152669,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2:0004048 EMAPA:27665 GAID:1309 - MESH:A16.254.570 + MESH:D009095 NCIT:C13260 RETIRED_EHDAA2:0001399 SCTID:308802006 @@ -152953,9 +153548,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]. check this + mesenchyme of kidney uberon UBERON:0003918 + kidney mesenchyme @@ -153569,8 +154166,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An gastrodermis - BGEE:ANN NCBITaxon:6073 + https://orcid.org/0000-0003-3308-6245 @@ -153877,7 +154474,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:273671 SCTID:314159008 Wikipedia:Transverse_temporal_gyrus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1520 + neuronames:1520 Heshl's gyrus transverse temporal gyrus uberon @@ -153946,7 +154543,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72255 HBA:4699 MA:0002969 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=656 + neuronames:656 anterior cerebellum vermis anterior vermis of cerebellum part of vermal region @@ -154036,7 +154633,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37954 NLXANAT:090818 Wikipedia:Somatosensory_system - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2887 + neuronames:2887 somatic sensory system somatosensory system system for detection of somatic senses @@ -154434,11 +155031,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The anterior segment of the lamellated connective tissue layer of the cornea. + anterior stroma EMAPA:37414 cornea anterior stroma uberon UBERON:0003952 + anterior stroma of cornea @@ -154536,7 +155135,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003954 squamoparietal suture - Gray188-Squamosal:suture.png + https://upload.wikimedia.org/wikipedia/commons/a/a8/Gray188-Squamosal_suture.png @@ -155008,7 +155607,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9240 MBA:940 SCTID:369084007 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1445 + neuronames:1445 cingulum bundle uberon cingulum of telencephalon @@ -155872,7 +156471,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:321547 HBA:9406 SCTID:314163001 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1213 + neuronames:1213 cerebellar fissure fissurae cerebelli uberon @@ -155942,6 +156541,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles. + EMAPA:30755 MA:0001710 NCIT:C33400 @@ -155950,6 +156550,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An primordial follicle uberon UBERON:0003981 + primordial ovarian follicle @@ -155985,6 +156586,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An . + Stage IV (690-730 microns) are oocyte maturation. Selman et al, 1993.[TAO] BTO:0000389 EFO:0003653 @@ -156000,6 +156602,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An preovulatory follicle UBERON:0003982 + mature ovarian follicle @@ -156058,6 +156661,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The funnel-like expansion of the abdominal extremity of the uterine tube[MP]. + The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]. In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct. infundibulum @@ -156071,9 +156675,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon infundibulum tubae uterinae UBERON:0003984 + uterine tube infundibulum - Illu:cervix.jpg + https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg @@ -156098,7 +156703,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct. - https://orcid.org/0000-0002-2825-0621 + https://orcid.org/0000-0002-2825-0621 @@ -156225,6 +156830,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages. + EMAPA:35395 MA:0000772 NCIT:C13170 @@ -156235,6 +156841,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymic corpuscle uberon UBERON:0003987 + Hassall's corpuscle @@ -156271,6 +156878,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells. + EMAPA:37974 thymic cortico-medullary boundary thymic corticomedullary boundary @@ -156282,6 +156890,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus corticomedullary zone uberon UBERON:0003988 + thymus corticomedullary boundary @@ -156363,7 +156972,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83734 SCTID:279288001 Wikipedia:Anterior_median_fissure_of_the_medulla_oblongata - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=700 + neuronames:700 anterior median fissure anterior median fissure of medulla anterior median fissure of medulla oblongata @@ -156455,7 +157064,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279449001 UMLS:C0152288 Wikipedia:Median_aperture - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=641 + neuronames:641 apertura mediana foramen of Magendie foramen of Majendie @@ -156550,7 +157159,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:63426007 UMLS:C0152287 Wikipedia:Lateral_aperture - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=640 + neuronames:640 apertura lateralis foramen of Key-Retzius foramen of Luschka @@ -156563,7 +157172,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0003992 fourth ventricle lateral aperture - Lateral:ventricle.gif + https://upload.wikimedia.org/wikipedia/commons/5/54/Lateral_ventricle.gif @@ -156661,7 +157270,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279248006 UMLS:C0016520 Wikipedia:Interventricular_foramina_(neural_anatomy) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=447 + neuronames:447 foramen Monroi foramen interventriculare interventricular foramen @@ -157376,7 +157985,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0002964 SCTID:279360009 Wikipedia:Posterior_lobe_of_cerebellum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=660 + neuronames:660 cerebellar posterior lobe cerebellum posterior lobe middle lobe-1 of cerebellum @@ -157523,8 +158132,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9611 NLXANAT:20081236 PBA:294021942 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2066 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2129 + neuronames:2066 + neuronames:2129 cerebellar paravermis cerebellum intermediate hemisphere intermediate part of spinocerebellum @@ -157629,7 +158238,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium. DHBA:12698 EHDAA2:0004401 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1373 + neuronames:1373 cerebellum plate uberon cerebellum roof plate @@ -157696,7 +158305,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4704 MA:0002970 NLXANAT:20081240 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=673 + neuronames:673 posterior cerebellum vermis vermis lobus posterior vermis of posterior lobe @@ -157887,8 +158496,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An labium minora labium minorum labium minus + labium minus pudendi uberon - labium minus pudendi UBERON:0004014 labium minora @@ -157931,11 +158540,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + labium minus pudendi Wikipedia:Labia_minora + + + + labium minus pudendi + doi:10.1002/ca.23705 + + @@ -158008,7 +158624,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -158383,7 +158999,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MGE - PMID:23375746 + PMID:23375746 @@ -158425,7 +159041,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An LGE - PMID:23375746 + PMID:23375746 @@ -158486,6 +159102,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An That portion of the chorionic wall in the region of its uterine attachment, which gives rise to chorionic villi; it consists of the mesoderm that lines the chorionic vesicle and, on the maternal side, of the trophoblast that lines the intervillous spaces; in the last half of gestation, the mesodermal connective tissue is largely replaced by fibrinoid material, and the amnionic membrane is adherent to the fetal side of the plate. + BTO:0002879 EMAPA:31872 NCIT:C34123 @@ -158493,6 +159110,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0230972 uberon UBERON:0004027 + chorionic plate @@ -158757,8 +159375,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32703 PBA:294021932 Wikipedia:Subplate - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3233 https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png/360px-Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png + neuronames:3233 cerebral cortex subplate subplate subplate zone @@ -158853,12 +159471,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp. + FMA:15843 is classified as primary follicle so it belongs here EMAPA:37960 FMA:15843 primary spleen B cell follicle uberon UBERON:0004041 + spleen primary B follicle @@ -158901,11 +159521,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp. + EMAPA:37961 secondary spleen B cell follicle splenic secondary B cell follicle uberon UBERON:0004042 + spleen secondary B follicle @@ -158918,7 +159540,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm @@ -158936,7 +159558,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An secondary spleen B cell follicle - CL:tm + CL:tm @@ -159106,7 +159728,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83718 NCIT:C32866 Wikipedia:Interpeduncular_cistern - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2353 + neuronames:2353 uberon cisterna interpeduncularis interpeduncular cistern @@ -159165,7 +159787,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:18212 FMA:83719 Wikipedia:Pontine_cistern - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=556 + neuronames:556 cisterna pontis uberon UBERON:0004048 @@ -159198,7 +159820,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BAMS:cmcis EMAPA:37814 FMA:74517 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=542 + neuronames:542 great cistern uberon UBERON:0004049 @@ -159333,7 +159955,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:56154003 UMLS:C0228150 Wikipedia:Cistern_of_great_cerebral_vein - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=26 + neuronames:26 ambient cistern cistern of great cerebral vein cisterna ambiens @@ -159639,6 +160261,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. + In ZFA, Digestive system duct that collects bile from the canaliculus and transports bile through the liver -- (check if the same) // The smallest and the most peripheral branches of the biliary tree consist of a portal part (portal ductule) and an intralobular part (intralobular ductule) BTO:0002840 EMAPA:37440 @@ -159653,6 +160276,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cholangiole terminal cholangiole UBERON:0004058 + biliary ductule @@ -159869,7 +160493,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. EMAPA:17148 EMAPA:35360 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1367 + neuronames:1367 neural tube intermediate zone uberon future brain marginal layer @@ -159936,7 +160560,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. EMAPA:17151 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1368 + neuronames:1368 neural tube marginal zone uberon brain marginal zone @@ -160038,7 +160662,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C34111 UMLS:C1511061 Wikipedia:Basal_plate_(neural_tube) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1372 + neuronames:1372 basal plate basal plate of neural tube spinal cord basal plate @@ -160366,7 +160990,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLX:53 NLXANAT:20090453 Wikipedia:Olfactory_bulb#Accessory_olfactory_bulb - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1565 + neuronames:1565 accessory (vomeronasal) bulb olfactory bulb accessory nucleus uberon @@ -160487,7 +161111,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9578 NLXANAT:20081242 Wikipedia:Interposed_nucleus - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1243 + neuronames:1243 interposed nucleus of cerebellum interposed nucleus of the cerebellum uberon @@ -160579,7 +161203,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279380005 SCTID:77232000 Wikipedia:Lingula_of_cerebellum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=657 + neuronames:657 lingula (I) lingula of anterior cerebellum vermis lingula of cerebellum @@ -160672,7 +161296,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000999 MBA:976 NLXANAT:20081225 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1054 + neuronames:1054 lobule II lobule II of cerebellum vermis vermic lobule II @@ -160752,7 +161376,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0001000 MBA:984 NLXANAT:20081226 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1844 + neuronames:1844 lobule III lobule III of cerebellum vermis vermic lobule III @@ -160891,7 +161515,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:957 NLXANAT:20081234 Wikipedia:Uvula_of_cerebellum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=678 + neuronames:678 cerebellar posterior vermis lobule IX lobule IX of cerebellar posterior vermis lobule IX of cerebellum vermis @@ -161005,7 +161629,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0001002 MBA:1001 NLXANAT:20081228 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1766 + neuronames:1766 lobule V lobule V (culmen and quadrangular lobule, posterior part) lobule V of cerebellum vermis @@ -161083,7 +161707,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An . UBERON:0000909 - UBERON:Declive-MA_0001003 declive declive lobule BAMS:DEC @@ -161095,7 +161718,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:936 NLXANAT:20081229 SCTID:279385000 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=674 + neuronames:674 declive (VI) declive of cerebellum declive of vermis of cerebellum @@ -161204,7 +161827,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLXANAT:20081230 SCTID:369044003 Wikipedia:Folium_(vermis) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2464 + neuronames:2464 folium-tuber vermis (VII) lobule VII of cerebellum vermis vermic lobule VII @@ -161266,7 +161889,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0001005 MBA:951 NLXANAT:20081233 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=677 + neuronames:677 cerebellum lobule VIII lobule VIII of cerebellum vermis neuraxis pyramis @@ -161362,7 +161985,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0001007 MBA:968 NLXANAT:20081235 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=681 + neuronames:681 lobule X of cerebellum vermis neuraxis nodule neuraxis nodulus @@ -161411,7 +162034,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nodulus MA:0001007 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=681 + neuronames:681 @@ -161542,8 +162165,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An labium majora labium majorum labium majus + labium majus pudendi uberon - labium majus pudendi UBERON:0004085 labium majora @@ -161581,11 +162204,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + labium majus pudendi Wikipedia:Labia_majora + + + + labium majus pudendi + doi:10.1002/ca.23705 + + @@ -161601,6 +162231,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid. + Organ cavity of the brain which consists of the lateral ventricles, the third and fourth ventricles and the cerebral aqueduct[BIRNLEX:1356]. FMA draws the distinction between e.g. 'fourth ventricle' and 'cavity of fourth ventricle'. The latter is a cavity, and part of the former, which is a region. The superclass of 'fourth ventricle' is_a 'region of ventricular system of the brain'. We place this class here, although it is not equivalent to ventricles, as it includes ventricle bodies. BIRNLEX:1356 @@ -161615,13 +162246,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An OpenCyc:Mx4rvmTY65wpEbGdrcN5Y29ycA SCTID:180929003 UMLS:C0007799 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2497 + neuronames:2497 brain ventricles cerebral ventricle region of ventricular system of brain uberon UBERON:0004086 + brain ventricle @@ -161694,8 +162326,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0004087 vena cava - Heart:numlabels.png http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png + https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png @@ -161961,7 +162593,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000721 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -162040,8 +162672,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An . + uberon UBERON:0004098 + tibial plateaux @@ -162098,6 +162732,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone. + FMA:265239 SCTID:279371005 Wikipedia:Collecting_duct_system @@ -162106,6 +162741,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon tubulus renalis colligens UBERON:0004100 + renal collecting system http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png @@ -162379,7 +163015,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:361736007 UMLS:C0222724 Wikipedia:Clivus_(anatomy) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=674 + neuronames:674 clivus occipital bone clivus uberon @@ -162716,7 +163352,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical structure that develops (entirely or partially) from the mesoderm. Grouping term for query purposes - FBbt:00025998 mesodermal derivative uberon UBERON:0004120 @@ -162750,7 +163385,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical structure that develops (entirely or partially) from the ectoderm. Grouping term for query purposes - FBbt:00025990 ectodermal deriviative uberon UBERON:0004121 @@ -163392,6 +164026,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the loop of Henle. It has a brush border epithelial morphology[GO]. TODO - ensure definition works across species. + BTO:0001498 CALOHA:TS-0509 EMAPA:28281 @@ -163402,6 +164037,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal proximal tubule uberon UBERON:0004134 + proximal tubule @@ -163570,7 +164206,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - BGEE:ann + https://orcid.org/0000-0003-3308-6245 @@ -163584,7 +164220,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] - GO + GO @@ -163662,7 +164298,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ZFA-modified + ZFA-modified @@ -164147,7 +164783,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:242003 UMLS:C0152301 Wikipedia:Orbitofrontal_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=91 + neuronames:91 fronto-orbital cortex orbital frontal cortex orbito-frontal cortex @@ -164219,7 +164855,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:424149007 UMLS:C1520137 Wikipedia:Anterior_white_commissure - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1641 + neuronames:1641 anterior white commissure anterior white commissure of spinal cord spinal cord anterior commissure @@ -164365,6 +165001,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + The external genitalia are the outer sex organs, such as the penis or vulva in mammals. FMA:45643 SCTID:362207005 @@ -164896,8 +165538,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The Harderian gland is an anterior orbital gland usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species[GO]. - - @@ -164942,18 +165582,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An GO:0070384 Wikipedia:Harderian_gland - - - - - PMID:7559104 - - - - - - PMID:7559104 - @@ -165072,6 +165700,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. TODO - check - GO says outer, BTO says inner. Make this a superclass + BTO:0001515 EMAPA:35458 MA:0002847 @@ -165082,6 +165711,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon glomerular epithelial cell UBERON:0004188 + glomerular epithelium @@ -165156,6 +165786,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. + glomerulus vasculature renal glomerulus vascular network renal glomerulus vasculature @@ -165163,6 +165794,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vasculature of renal glomerulus uberon UBERON:0004190 + renal glomerulus vasculature @@ -165222,6 +165854,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A sub-portion of the loop of Henle in the nephron of the kidney that is permeable to ions but not to water. check relationship to distal tubule + EMAPA:28328 EMAPA:28361 FMA:17720 @@ -165234,6 +165867,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thin ascending limb of loop of Henle uberon UBERON:0004193 + loop of Henle ascending limb thin segment http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png @@ -165409,6 +166043,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts. + not the same as FMA:50609 Pyramid (which is a volume / dimensional entity) UBERON:0002449 @@ -165435,9 +166070,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pyramis renalis renal medullary region UBERON:0004200 + kidney pyramid - Kidney:PioM.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png @@ -165535,6 +166171,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thick and thin portions of nephron tubules. + EMAPA:29675 FMA:76663 MA:0002626 @@ -165546,6 +166183,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stria interna medullae renalis uberon UBERON:0004201 + kidney outer medulla inner stripe @@ -165607,6 +166245,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outer stripe is the region of the kidney that lies distal to the line of termination of the straight renal tubules. + EMAPA:29663 FMA:76662 MA:0002629 @@ -165618,6 +166257,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stria externa medullae renalis uberon UBERON:0004202 + kidney outer medulla outer stripe @@ -165802,6 +166442,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus. + Capillary that is part of the renal glomerulus. Glomerular capillary endothelial membranes in zebrafish normally have a fenestrated morphology that is visible at the ultrastructural level.[TAO] EMAPA:28245 FMA:274259 @@ -165821,6 +166462,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glomerular capillaries glomerular capillary system UBERON:0004212 + glomerular capillary @@ -168559,6 +169201,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An endothelium that is part of a glomerular capillary. + MA:0001658 NCIT:C32522 SCTID:243993006 @@ -168566,6 +169209,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal glomerulus capillary endothelium uberon UBERON:0004294 + glomerular capillary endothelium @@ -168960,31 +169604,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An forelimb coffin bone - NCBITaxon:9787 + NCBITaxon:9787 forelimb medial claw of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 forelimb medial claw of ruminant hoof - NCBITaxon:91561 + NCBITaxon:91561 forelimb medial ungual phalanx of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 forelimb pedal bone - NCBITaxon:9787 + NCBITaxon:9787 @@ -169475,31 +170119,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hindlimb coffin bone - NCBITaxon:9787 + NCBITaxon:9787 hindlimb medial claw of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 hindlimb medial claw of ruminant hoof - NCBITaxon:91561 + NCBITaxon:91561 hindlimb medial ungual phalanx of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 hindlimb pedal bone - NCBITaxon:9787 + NCBITaxon:9787 @@ -171999,7 +172643,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2:0001504 EMAPA:16107 EMAPA_RETIRED:16084 - MESH:A16.254.403.147 + MESH:D000482 NCIT:C34101 RETIRED_EHDAA2:0000114 SCTID:308825007 @@ -172085,6 +172729,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:185 EMAPA:16072 FMA:293110 + MESH:D054240 NCIT:C28402 SCTID:361438007 UMLS:C0033153 @@ -172448,7 +173093,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35944 FMA:296780 GAID:1307 - MESH:A16.254.462 + MESH:D018878 NCIT:C34203 UMLS:C0282505 Wikipedia:Limb_bud @@ -173306,7 +173951,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000122 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -174920,8 +175565,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An carpal region - Hand:parts.jpg - Human:wrist.png + https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png + https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg @@ -174940,13 +175585,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An fore basipodium - MA:th + MA:th fore mesopodium - MA:th + MA:th @@ -175015,7 +175660,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0004453 metacarpus region - Metacarpals:numbered-en.svg + https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg @@ -175102,8 +175747,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:9665 GAID:41 MA:0000043 - MESH:A01.378.610.250.149 - MESH:A13.473.821 + MESH:D000842 OpenCyc:Mx4rvVi-R5wpEbGdrcN5Y29ycA SCTID:361292008 Wikipedia:Ankle @@ -175121,7 +175765,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tarsal region - Ankle:en.svg + https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg @@ -175153,13 +175797,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hind basipodium - MA:th + MA:th hind mesopodium - MA:th + MA:th @@ -176166,6 +176810,63 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + + + + + + Any collection of muscles that is part of a perineum [Automatically generated definition]. + currently defined by location rather than attachment + EMAPA:36629 + FMA:71295 + musculi perinei + perineal muscles + perineal muscles set + set of perineal muscles + uberon + UBERON:0004486 + musculature of perineum + + + + + Any collection of muscles that is part of a perineum [Automatically generated definition]. + OBOL:automatic + + + + + musculi perinei + FMA:71295 + FMA:TA + + + + + + perineal muscles + FMA:71295 + + + + + perineal muscles set + FMA:71295 + + + + + set of perineal muscles + FMA:71295 + + + + @@ -176252,7 +176953,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging. - GO + GO @@ -176454,6 +177155,44 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + + + + + + Any muscle organ that is part of a anal part of perineum. + FMA:77304 + anal triangle muscle + uberon + UBERON:0004519 + muscle of anal triangle + + + + + + FMA + + + + + Any muscle organ that is part of a anal part of perineum. + OBOL:automatic + + + + + anal triangle muscle + FMA:77304 + + + + @@ -176901,6 +177640,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep. consider merging with parent + A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO] FMA:63815 TAO:0005105 @@ -176914,6 +177654,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon lymph vessels UBERON:0004536 + lymph vasculature @@ -176967,6 +177708,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vascular network consisting of blood vessels. + TAO:0001079 ZFA:0001079 blood vascular network @@ -176976,6 +177718,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An blood vessel system blood vessels UBERON:0004537 + blood vasculature @@ -177068,7 +177811,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279300007 UMLS:C0152345 Wikipedia:External_capsule - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=253 + neuronames:253 uberon capsula externa corpus callosum external capsule @@ -177248,14 +177991,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An LES - Wikipedia:Cardia + Wikipedia:Cardia cardiac sphincter - Wikipedia:Cardia + Wikipedia:Cardia @@ -177268,55 +178011,55 @@ A continuant cannot be part of an occurrent: use 'participates in'. An esophageal sphincter - Wikipedia:Cardia + Wikipedia:Cardia esophageal sphincter%2c lower - Wikipedia:Cardia + Wikipedia:Cardia esophageal-cardiac junction - Wikipedia:Cardia + Wikipedia:Cardia esophagogastric junction - Wikipedia:Cardia + Wikipedia:Cardia gastro-esophageal junction - Wikipedia:Cardia + Wikipedia:Cardia gastro-esophageal sphincter - Wikipedia:Cardia + Wikipedia:Cardia gastro-oesophageal junction - Wikipedia:Cardia + Wikipedia:Cardia gastroesophageal junction - Wikipedia:Cardia + Wikipedia:Cardia gastroesophageal sphincter - Wikipedia:Cardia + Wikipedia:Cardia @@ -177328,7 +178071,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lower esophageal sphincter - Wikipedia:Cardia + Wikipedia:Cardia @@ -178070,6 +178813,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism. + EMAPA:28230 EMAPA:28266 FMA:77042 @@ -178086,6 +178830,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteriola glomerularis afferens UBERON:0004639 + renal afferent arteriole @@ -178153,6 +178898,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule. + EMAPA:28233 EMAPA:28275 FMA:77043 @@ -178169,6 +178915,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteriola glomerularis efferens capsulae renalis UBERON:0004640 + renal efferent arteriole @@ -178236,6 +178983,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The connective tissue that surrounds the spleen. + EMAPA:35802 FMA:15849 MA:0000753 @@ -178252,6 +179000,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tunica fibrosa splenica uberon UBERON:0004641 + spleen capsule @@ -178337,6 +179086,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The epithelial lining of the luminal space of the urinary bladder. + 5-7 cell layers thick in contracted bladder, 2-3 cells thick in distended bladder; lines renal pelvis, ureters, bladder, most of urethra but not distal urethra urothelium BTO:0001694 @@ -178355,6 +179105,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epithelium of bladder transitional epithelium UBERON:0004645 + urinary bladder urothelium @@ -178421,6 +179172,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted]. + EMAPA:37090 FMA:49767 MA:0001977 @@ -178432,6 +179184,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon a. infraorbitalis UBERON:0004646 + infraorbital artery http://upload.wikimedia.org/wikipedia/commons/a/aa/Gray511.png @@ -178482,6 +179235,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.[WP] + EMAPA:35499 FMA:14471 MA:0002494 @@ -178496,6 +179250,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lobules of liver lobuli hepatis UBERON:0004647 + liver lobule @@ -179008,7 +179763,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0001673 coronoid process, a bony projection on dentary - TAO + TAO @@ -179578,7 +180333,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:12766003 UMLS:C0014472 Wikipedia:Ependyma - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1856 + neuronames:1856 ependyma of neuraxis ependymal epithelium uberon @@ -179649,8 +180404,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362427009 UMLS:C1512274 Wikipedia:Gray_commissure - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1649 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1702 + neuronames:1649 + neuronames:1702 area spinalis X gray commissure of spinal cord lamina X @@ -180094,8 +180849,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An PBA:128013018 TAO:0000653 ZFA:0000653 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1455 ncithesaurus:Dorsal_Thalamus + neuronames:1455 dorsal thalamus dorsal thalamus (Anthoney) thalamus dorsalis @@ -180326,7 +181081,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An primitive right ventricle endocardium EHDAA2:0000197 - JB:def @@ -180619,8 +181373,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. BTO:0001744 CALOHA:TS-0497 @@ -180691,7 +181444,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362313003 UMLS:C0036700 Wikipedia:Septum_pellucidum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=256 + neuronames:256 septal pellucidum septum pellucidum of telencephalic ventricle supracommissural septum @@ -180726,7 +181479,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=256 + neuronames:256 BIRNLEX:1315 @@ -180817,6 +181570,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins. + arcuate vein EMAPA:28221 @@ -180831,9 +181585,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arcuate veins UBERON:0004719 + kidney arcuate vein - Kidney:PioM.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png @@ -180894,6 +181649,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally). + In bony fish, or teleosts, it has been proposed that the cerebellar auricles, which receive a large amount of input from the vestibulolateral line system, constitute the vestibulocerebellum and are homologues of the flocculonodular lobe of higher vertebrates along with the corpus cerebelli, which receives spinocerebellar and tectocerebellar fibers. The labyrinth and the lateral line organs of lampreys have structural and functional similarity. An important difference between the two structures is that the arrangement of the lateral line organs are such that they are sensitive to relative motion of the fluid surrounding the animal, whereas the labyrinths, having very similar sensing mechanisms, are sensitive to endolymph, providing information concerning the animal's own equilibrium of the body and orientation in space we follow MBA and NIFSTD in making this part of the cerebellar cortex, but FMA may handle this differently BAMS:VERM @@ -180909,11 +181665,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4698 MA:0000202 MBA:645 + MESH:D065814 NCIT:C33866 SCTID:279105006 UMLS:C0228482 Wikipedia:Cerebellar_vermis - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2463 + neuronames:2463 cerebellum vermis vermal parts of the cerebellum vermal regions @@ -180924,6 +181681,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vermis vermis cerebelli UBERON:0004720 + cerebellar vermis http://upload.wikimedia.org/wikipedia/commons/4/43/CerebellumDiv.png @@ -181091,6 +181849,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule. + EMAPA:28212 FMA:70498 MA:0002584 @@ -181107,6 +181866,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An interlobular renal interlobular artery UBERON:0004723 + interlobular artery http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png @@ -181183,6 +181943,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions. + Piriform cortical regions are present in the brains of amphibians, reptiles and mammals. The piriform cortex is among three areas that emerge in the telencephalon of amphibians, situated caudally to a dorsal area, which is caudal to a hippocampal area. Farther along the phylogenic timeline, the telencephalic bulb of reptiles as viewed in a cross section of the transverse plane extends with the archipallial hippocampus folding toward the midline and down as the dorsal area begins to form a recognizable cortex. As mammalian cerebrums developed, volume of the dorsal cortex increased in slightly greater proportion, as compared proportionally with increased overall brain volume, until it enveloped the hippocampal regions. Recognized as neopallium or neocortex, enlarged dorsal areas envelop the paleopallial piriform cortex in humans and Old World monkeys. Among taxonomic groupings of mammals, the piriform cortex and the olfactory bulb become proportionally smaller in the brains of phylogenically younger species. The piriform cortex occupies a greater proportion of the overall brain and of the telencephalic brains of insectivores than in primates. The piriform cortex continues to occupy a consistent albeit small and declining proportion of the increasingly large telencephalon in the most recent primate species while the volume of the olfactory bulb becomes less in proportion BAMS:PIR BAMS:Pir @@ -181193,10 +181954,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100178 HBA:10142 MA:0000978 + MESH:D066195 SCTID:369098004 UMLS:C0228280 Wikipedia:Piriform_cortex - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=165 + neuronames:165 cortex piriformis primary olfactory areas uberon @@ -181212,6 +181974,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pyriform lobe regio praepiriformis UBERON:0004725 + piriform cortex http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG @@ -181238,7 +182001,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=165 + neuronames:165 BIRNLEX:1097 @@ -181335,6 +182098,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In the blood supply of the kidney, the vasa recta renis (or straight arteries of kidney, or straight arterioles of kidney) form a series of straight capillaries in the medulla. They lie parallel to the loop of Henle. These vessels branch off the efferent arterioles of juxtamedullary nephrons (those nephrons closest to the medulla), enter the medulla, and surround the loop of Henle. TODO - is this a vein or set of veins? in MA it is a venous blood vessel + EMAPA:30043 FMA:72006 MA:0002595 @@ -181354,9 +182118,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An arteriolae recti vasa rectae UBERON:0004726 + vasa recta - Kidney:nephron.png + https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png @@ -181466,7 +182231,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0009201 VHOG:0001182 Wikipedia:Cochlear_nerve - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1406 + neuronames:1406 auditory nerve cochlear root of acoustic nerve cochlear root of eighth cranial nerve @@ -181544,7 +182309,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). We take the definition of neuromere from Puelles et al, although the existence of mesomeres and prosomeres may not be widely accepted A metameric segment of the central nervous system.[ZFA] - Melissa Haendel + 2009-06-18T09:00:04Z NLX:147842 TAO:0001328 @@ -181605,7 +182370,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451) - FBbt:00005140 uberon neuromere UBERON:0004732 @@ -181688,7 +182452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FBbt:00005317 FMA:293108 GAID:1302 - MESH:A16.254.412 + MESH:D005775 MIAA:0000179 NCIT:C34057 NCIT:C34058 @@ -181721,7 +182485,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An We explicitly merge the NCITA terms here - NCIT + NCIT @@ -182050,6 +182814,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An AAO:0000043 BTO:0000494 BTO:0001504 + MESH:D054239 NCIT:C34150 TAO:0001175 Wikipedia:Germinal_disc @@ -182108,7 +182873,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A layer of cells formed at one pole of macrolecithal eggs such as the yolky egg of birds. The yolk prevents the division from taking place through the egg, resulting in meroblastic cleavage during the many cleavage divisions. At the animal pole (containing less yolk than the vegetal pole), the zygote divides and subdivides, forming the blastoderm, which gradually spreads around the yolk and forms the embryo. The blastoderm is composed of two layers, the epiblast and the hypoblast, which enclose the fluid-filled blastocoel cavity. AAO:0000042 BTO:0000126 - MESH:A16.254.085.067 + MESH:D001756 TAO:0001176 Wikipedia:Blastoderm ZFA:0001176 @@ -183754,15 +184519,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The thymic connective tissue which extends into the parenchyma. + MA:0002674 NCIT:C33773 UMLS:C1515431 thymic trabecula thymus gland trabecula + thymus trabeculae trabecula of thymus trabecula of thymus gland uberon UBERON:0004791 + thymus trabecula @@ -183803,6 +184571,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An thymus gland trabecula OBOL:automatic + + + + thymus trabeculae + + @@ -183882,7 +184656,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0004797 blood vessel layer - Blood:vessels.svg + https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg @@ -183904,6 +184678,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium that is part of a uterine cervix [Automatically generated definition]. + The epithelium of the cervix is varied. The ectocervix (more distal, by the vagina) is composed of nonkeratinized stratified squamous epithelium. The endocervix (more proximal, within the uterus) is composed of simple columnar epithelium BTO:0000241 CALOHA:TS-0137 @@ -183920,6 +184695,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0004801 + cervix epithelium @@ -184056,6 +184832,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium that is part of a oviduct [Automatically generated definition]. + in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label BTO:0002402 CALOHA:TS-1316 @@ -184071,6 +184848,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An columnar epithelium of the oviduct fallopian tube epithelium UBERON:0004804 + oviduct epithelium @@ -185431,6 +186209,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vasculature that is part of a retina [Automatically generated definition]. + FMA:76552 MESH:D012171 XAO:0004153 @@ -185444,6 +186223,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vasa sanguinea retinae uberon UBERON:0004864 + vasculature of retina @@ -185995,12 +186775,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The mass of tissue made up of mesenchymal cells in the lung. + EMAPA:32866 lung-associated mesenchyme mesenchyme of lung pulmonary mesenchyme uberon UBERON:0004883 + lung mesenchyme @@ -186504,7 +187286,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts EHDAA:4032 EHDAA:5931 - FBbt:00004859 NCIT:C32676 UMLS:C1517534 gonad epithelium @@ -186561,7 +187342,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts BTO:0001364 EMAPA:17973 - FBbt:00004955 testis epithelium testis sheath uberon @@ -186603,7 +187383,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An epithelium surrounding an ovary. after reasoning this should subsume the more specific germinal epithelium classes. We include the fly structure here although it is not clear if the sheath is an epithelium or a multi-tissue structure that includes epithelium as parts BTO:0003661 - FBbt:00004896 ovarian epithelium ovary epithelium ovarian sheath @@ -186814,7 +187593,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLX:144262 PBA:294021970 Wikipedia:Subventricular_zone - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1901 + neuronames:1901 SEZ SVZ adult subventricular zone @@ -188690,7 +189469,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0814992 Wikipedia:Neural_groove XAO:0000248 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1363 + neuronames:1363 uberon UBERON:0005061 neural groove @@ -188741,7 +189520,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0814993 Wikipedia:Neural_fold XAO:0004087 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1364 + neuronames:1364 medullary fold uberon UBERON:0005062 @@ -188968,7 +189747,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:16904 VHOG:0001547 Wikipedia:Lamina_terminalis - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=208 + neuronames:208 uberon UBERON:0005078 lamina terminalis of neural tube @@ -189105,7 +189884,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures - GO + GO https://github.com/geneontology/go-ontology/issues/12223#issuecomment-215692347 @@ -189160,7 +189939,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -189172,7 +189951,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hair placode - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -189184,7 +189963,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hair germ - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -189370,7 +190149,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila EMAPA:32715 - FBbt:00005073 FMA:30316 musculus uberon @@ -189765,6 +190543,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins. + EMAPA:28218 FMA:71634 MA:0002594 @@ -189776,6 +190555,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An set of interlobular veins of kidney venae interlobulares renis UBERON:0005168 + renal interlobular vein http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png @@ -189829,12 +190609,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Connective tissue between the cellular elements of a structure. specify differentia from stroma + interstital FMA:86301 SCTID:85293002 interstitium uberon UBERON:0005169 + interstitial tissue @@ -190090,7 +190872,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32888 FMA:312389 MA:0001604 - MESH:A14.254.900.720.265 + MESH:D004658 SCTID:362863002 TAO:0005138 Wikipedia:Enamel_organ @@ -190435,6 +191217,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen. + EMAPA:35803 MA:0000764 NCIT:C49760 @@ -190445,6 +191228,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An splenic germinal center uberon UBERON:0005196 + spleen germinal center @@ -190457,13 +191241,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen. - CL:tm + CL:tm https://github.com/obophenotype/uberon/issues/6 @@ -190593,9 +191377,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - + @@ -190603,6 +191385,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + These glands secrete mucus, lysozyme, defensins, and other agents that help protect the lungs from particles and infectious agents. EMAPA:36574 FMA:7473 @@ -190613,6 +191396,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon tubular seromucous gland of trachea UBERON:0005203 + trachea gland @@ -190774,6 +191558,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes. See https://sourceforge.net/p/geneontology/ontology-requests/10941/ + The interstitium is necessarily involved in all intrarenal exchange processes since the reabsorption and secretion of fluid and solutes implicates a transit across the interstitial compartment. The fibroblasts in the interstitium provide the 'skeleton' of the tissue and maintain the three-dimensional architecture of the tissue. EMAPA:28518 @@ -190789,6 +191574,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon kidney interstitium group UBERON:0005215 + kidney interstitium @@ -190830,7 +191616,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + @@ -191377,11 +192163,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure. + EMAPA:36558 MA:0002588 Wikipedia:Peritubular_capillaries uberon UBERON:0005272 + peritubular capillary @@ -191546,7 +192334,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0001261 Wikipedia:Ventricular_system ZFA:0001261 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2497 + neuronames:2497 CNS ventricular system ventricular system ventricular system of neuraxis @@ -191675,7 +192463,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000447 Wikipedia:Tela_chorioidea ZFA:0000447 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1378 + neuronames:1378 uberon tela chorioidea UBERON:0005283 @@ -191747,6 +192535,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:17082 HBA:9512 MA:0000205 + MESH:D054024 VHOG:0000456 Wikipedia:Myelencephalon uberon @@ -192329,6 +193118,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The gangliated plexus of unmyelinated nerve fibers that ramify the stomach and intestinal submucosa. + in FMA this is part of the esophagus, duodenum and intestine; this violates part-disjointness axioms in uberon EMAPA:35834 FMA:21542 @@ -192345,6 +193135,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Meissner's plexus meissner's plexus UBERON:0005304 + submucous nerve plexus @@ -192850,7 +193641,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32711 MBA:695 PBA:294021914 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2702 + neuronames:2702 cerebral cortex cortical plate future cortical layers II-VI neocortex cortical plate @@ -192878,7 +193669,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An CxP - PMID:23375746 + PMID:23375746 @@ -192997,7 +193788,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37823 FMA:83889 NLXANAT:20081231 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=675 + neuronames:675 folium of vermis of cerebellum vermic lobule VIIA folium lobule @@ -193072,7 +193863,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12940 HBA:4708 NLXANAT:20081232 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=676 + neuronames:676 lobule VII B of vermis neuraxis tuber tuber of vermis of cerebellum @@ -193170,7 +193961,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BAMS:COPY EMAPA:37400 MBA:1033 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1894 + neuronames:1894 uberon UBERON:0005347 @@ -193237,7 +194028,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37397 FMA:72257 MBA:1017 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=666 + neuronames:666 ansiform lobule of cerebellum ansiform lobule of cerebellum [hVIIa] lobuli semilunares cerebelli @@ -193370,7 +194161,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12942 MBA:1025 NLXANAT:20081210 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=669 + neuronames:669 gracile lobule hemispheric lobule VIIBii lobule VIIIB (pyramis and biventral lobule, posterior part) @@ -193520,7 +194311,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72522 MBA:1007 NLXANAT:20081206 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=665 + neuronames:665 hemispheric lobule VI lobule h VI of larsell lobulus quadrangularis pars caudalis/posterior @@ -193731,7 +194522,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:314174005 SCTID:51969002 Wikipedia:Cerebellar_tonsil - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=672 + neuronames:672 cerebellar tonsil neuraxis paraflocculus parafloccular lobule of cerebellum @@ -193851,7 +194642,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0005352 spermatic cord - Male:anatomy.png + https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png @@ -193894,6 +194685,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The perifollicular zone, which is present in human and not rodents, may be the functional equivalent of the marginal sinus in rodents. uberon UBERON:0005353 + spleen perifollicular zone @@ -194034,7 +194826,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An VHOG:0000674 Wikipedia:Rathke's_pouch XAO:0000430 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1516 + neuronames:1516 Rathke pouch pouch of Rathke Rathkes pouch epithelium @@ -194799,7 +195591,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000685 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -195016,7 +195808,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33204 UMLS:C0178780 VHOG:0000833 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2078 + neuronames:2078 uberon UBERON:0005366 @@ -195084,7 +195876,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BIRNLEX:1211 EMAPA:35408 MA:0000955 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1742 + neuronames:1742 hippocampal molecular layer hippocampus stratum moleculare molecular layer of hippocampus @@ -195111,7 +195903,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An molecular layer of hippocampus BIRNLEX:1211 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1742 + neuronames:1742 @@ -195157,7 +195949,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35412 FMA:83893 MA:0000958 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 + neuronames:157 oriens layer of hippocampus oriens layer of the hippocampus polymorphic layer of hippocampus @@ -195179,7 +195971,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 + neuronames:157 BIRNLEX:4113 @@ -195241,7 +196033,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35413 FMA:83894 MA:0000959 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=158 + neuronames:158 radiate layer of hippocampus stratum radiatum stratum radiatum hippocampi @@ -195260,7 +196052,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=158 + neuronames:158 BIRNLEX:1298 @@ -195314,7 +196106,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C0458459 VHOG:0001623 Wikipedia:Posterior_column - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2681 + neuronames:2681 dorsal column dorsal column of spinal cord posterior column @@ -195388,7 +196180,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0000531 VHOG:0001621 ZFA:0000531 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1673 + neuronames:1673 uberon lateral column lateral columns @@ -195440,7 +196232,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EV:0100326 MA:0002751 VHOG:0001622 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=269 + neuronames:269 anterior column spinal cord anterior column ventral column @@ -195551,7 +196343,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLXANAT:1005007 TAO:0000357 ZFA:0000357 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2710 + neuronames:2710 olfactory bulb main glomerulus stratum glomerulosum bulbi olfactorii uberon @@ -195609,7 +196401,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000971 MBA:220 NLXANAT:20090404 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2714 + neuronames:2714 olfactory bulb main granule cell layer uberon accessory olfactory bulb granule cell layer @@ -195682,7 +196474,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35610 MA:0000972 MBA:228 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2713 + neuronames:2713 internal plexiform layer uberon inner plexiform layer of the main olfactory bulb @@ -195756,7 +196548,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83146 MA:0000946 MBA:632 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2122 + neuronames:2122 DG granule cell layer granular layer of dentate gyrus stratum granulare gyri dentati @@ -195835,7 +196627,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLXANAT:1010001 PBA:10081 Wikipedia:Dorsal_striatum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2340 + neuronames:2340 striatum dorsal region uberon caudoputamen @@ -195892,7 +196684,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance. - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2340 + neuronames:2340 @@ -196279,7 +197071,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLXANAT:090808 PBA:294021800 UMLS:C1517039 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2446 + neuronames:2446 cerebral cortex, layer 2 external granular layer of isocortex [layer II] external granular layer of neocortex @@ -196718,10 +197510,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:77614 MA:0002972 MBA:493 + MESH:D066328 NLX:57107 PBA:10091 Wikipedia:Ventral_striatum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2341 + neuronames:2341 striatum ventral region uberon striatum ventrale @@ -196751,7 +197544,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 ). - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2341 + neuronames:2341 @@ -196834,9 +197627,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35243 FMA:84081 MA:0002942 + MESH:D066280 NLXANAT:20090312 Wikipedia:Circumventricular_organs - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1242 + neuronames:1242 CVO circumventricular organ circumventricular organ of neuraxis @@ -196898,7 +197692,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:71132 GAID:294 MA:0000323 - MESH:A03.492 + MESH:D041981 NCIT:C12378 SCTID:373871007 UMLS:C0012240 @@ -197287,7 +198081,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NLX:60355 NLXANAT:1005036 Wikipedia:Spinocerebellar_tract - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1978 + neuronames:1978 uberon UBERON:0005413 @@ -197596,7 +198390,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001260 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 http://bgee.unil.ch/ @@ -198188,11 +198982,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice. + The sinus, before entering the auricle, is considerably dilated - nearly to the size of the end of the little finger. Its wall is partly muscular, and at its junction with the great coronary vein is somewhat constricted and furnished with a valve consisting of two unequal segments EHDAA2:0000320 EHDAA:9884 EMAPA:37836 FMA:4706 + MESH:D054326 NCIT:C32378 SCTID:244386006 UMLS:C0456944 @@ -198201,6 +198997,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon sinus coronarius UBERON:0005438 + coronary sinus http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray491.png @@ -198344,7 +199141,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000923 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -198597,6 +199394,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids. + EMAPA:37880 FMA:14655 hepatic lamina @@ -198606,6 +199404,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon hepatic plate UBERON:0005452 + hepatic cord @@ -199064,6 +199863,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Either of the two lateral lobes that constitute the thymus. + each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. Each lobe is composed of numerous lobules held together by delicate areolar tissue; the entire organ being enclosed in an investing capsule of a similar but denser structure. The primary lobules vary in size from that of a pin's head to that of a small pea, and are made up of a number of small nodules or follicles.[WP] FMA:71193 RETIRED_EHDAA2:0002021 @@ -199071,6 +199871,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lobe of thymus uberon UBERON:0005483 + thymus lobe @@ -199398,7 +200199,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - ZFA-modified + ZFA-modified @@ -199596,7 +200397,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001372 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) http://bgee.unil.ch/ @@ -200902,7 +201703,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the mesocardium dorsal to the embryonic heart; it breaks down to form the transverse sinus of the pericardium. - MA:th + MA:th @@ -201298,7 +202099,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outgrowths of the embryonic maxillary prominences that come together during prenatal development to form the secondary palate. http://medical-dictionary.thefreedictionary.com/palatal+shelves - http://www.indiana.edu/~anat550/hnanim/face/face.html + http://www.indiana.edu/~anat550/hnanim/face/face.html @@ -201394,7 +202195,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An consider reversing - VHOG + VHOG @@ -201405,7 +202206,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -201432,7 +202233,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The shelf separating the oral and nasal cavities that is formed during early embryonic development from protrusions of tissue between the olfactory pits. [TFD][VHOG] 2012-09-17 VHOG:0000362 - VHOG + VHOG http://bgee.unil.ch/ http://medical-dictionary.thefreedictionary.com/primary+palate @@ -201442,7 +202243,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Early tetrapod possessed a primary palate that included the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. Therapsid evolved a partial secondary palate formed by the medial extension of the premaxilla and maxilla. Mammals have a secondary palate that, in addition to extensions of the premaxilla and maxilla, includes part of the palatine bone[VHOG] 2012-11-28 VHOG:0000362 - VHOG + VHOG ISBN:978-0072528305 Kardong http://bgee.unil.ch/ @@ -201633,6 +202434,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2 is a mereological sum. EHDAA2:0004714 FMA:305915 + MESH:D005321 SCTID:362840007 uberon UBERON:0005631 @@ -201690,7 +202492,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001081 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -201811,7 +202613,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0001102 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -202201,7 +203003,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tunica externa vasorum UBERON:0005734 tunica adventitia of blood vessel - Illu:artery.jpg + https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg @@ -202274,8 +203076,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + BTO:0002010 FMA:45635 + MESH:D063194 SCTID:30180000 Wikipedia:Adventitia tunica advetitia @@ -202283,6 +203087,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0005742 + adventitia http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg @@ -202391,7 +203196,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In teleost fishes the opening is wider that in mammals. Due to the longer and deeper shape in mammals, this is usually called the optic canal; sometimes the term optic foramen may be used for the opening of the canal, but here we use this term to denote the entire space together with surrounding bone surface. optic foramen - Orbita:mensch.jpg + https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg @@ -202633,6 +203438,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A single layer of simple squamous epithelium in the glomerular capsule. Does not function in filtration[UBERON]. outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium[MP]. TODO - check this. BTO has podocytes under here + Simple squamous epithelium that lines the capsule of the renal glomerulus.[TAO] BTO:0002296 EMAPA:27979 @@ -202659,6 +203465,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon kidney parietal epithelium UBERON:0005750 + glomerular parietal epithelium @@ -202763,16 +203570,18 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - + - The inner, or visceral, layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer, or parietal, layer by the capsular (Bowman's) space[BTO]. Lies just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]. + The inner (visceral) layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer (parietal) layer by the capsular (Bowman's) space[BTO]. This epithelial layer is superficially adjacent to the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. This inner epithelial layer of the glomerular capsule surrounds the capillary endothelial cells and is composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the inner visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]. TODO - check - the BTO class 'glomerular epithelium' is the visceral layer. But GO uses 'glomerular epithelium' as the mereological sum of P+V layers + EMAPA:28254 FMA:74273 + MA:0002607 NCIT:C33879 SCTID:244093000 UMLS:C0227644 @@ -202787,12 +203596,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0005751 - visceral layer of glomerular capsule + Formerly had rdfs:label 'visceral layer of glomerular capsule'. The current label 'glomerular visceral epithelium' was copied from UBERON:0006852, which is now obsolete since it represented the same entity as this IRI. + glomerular visceral epithelium - The inner, or visceral, layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer, or parietal, layer by the capsular (Bowman's) space[BTO]. Lies just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]. + The inner (visceral) layer of the renal glomerular capsule, overlying the capillaries, composed of podocytes, and separated from the outer (parietal) layer by the capsular (Bowman's) space[BTO]. This epithelial layer is superficially adjacent to the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries[WP]. This inner epithelial layer of the glomerular capsule surrounds the capillary endothelial cells and is composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the inner visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space)[MP]. BTO:0001515 MP:0011497 @@ -203054,12 +203864,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - An acellular anatomical structure that is the bounding layer of a anatomical structure. FMA:63871 uberon @@ -203167,6 +203971,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:30965 FMA:74274 MA:0001659 + MESH:D050533 NCIT:C32683 SCTID:243897006 TAO:0005285 @@ -203445,7 +204250,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000264 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 http://bgee.unil.ch/ @@ -203749,7 +204554,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0002181 Wikipedia:Cephalic_flexure ZFA:0001640 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1360 + neuronames:1360 cephalic flexure cerebral flexure cranial flexure @@ -203836,7 +204641,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A ventrally concave flexure of the embryonic brain occurring at the junction of hindbrain and spinal cord[MP]. In humans develops by the 5th week of gestation - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1359 + neuronames:1359 uberon UBERON:0005819 @@ -203869,7 +204674,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A dorsally concave bend of the embryonic rhombencephalon that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and myelencephalon in the embryo[MP]. Wikipedia:Pontine_flexure - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1361 + neuronames:1361 (embryonic) hindbrain flexure basicranial flexure pontal flexure @@ -204761,7 +205566,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The mantle layer of the neural tube that lies dorsal to the sulcus limitans and contains primarily sensory neurons and interneurons involved in communication of sensory impulses. Wikipedia:Alar_plate - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1370 + neuronames:1370 alar plate alar plate of neural tube uberon @@ -204877,7 +205682,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An it's not clear where AAO:'hyobranchial skeleton' belongs - AAO + AAO @@ -204969,7 +205774,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx. EMAPA:37304 MA:0000670 - MESH:A02.835.232.500 + MESH:D007867 uberon UBERON:0005893 @@ -205049,7 +205854,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35354 GAID:192 MA:0000643 - MESH:A02.835.232.300 + MESH:D005529 NCIT:C13068 OpenCyc:Mx4rv5ridZwpEbGdrcN5Y29ycA SCTID:361371005 @@ -205105,7 +205910,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO:0001414 XAO:0003173 ZFA:0001414 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2431 + neuronames:2431 basicranial region occipital part of head occipital region of head @@ -205505,7 +206310,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Thickening of the proximal end of the hair follicle. Contains rapidly proliferating, rather undifferentiated matrix cells (transient amplifying cells), melanocytes and outer root sheath cells. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -205650,7 +206455,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A stratified epithelium that surrounds the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 http://www.keratin.com/aa/aa022.shtml https://github.com/obophenotype/mouse-anatomy-ontology/issues/56 @@ -206234,7 +207039,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The portion of the hair follicle from the entrance of the sebaceous gland duct to the epidermal surface opening. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 ISBN:0123813611 https://github.com/obophenotype/mouse-anatomy-ontology/issues/76 @@ -206284,7 +207089,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C12803 SCTID:280694002 UMLS:C0040573 - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork eye trabecular meshwork reticulum trabeculare trabecular meshwork of the eye @@ -206316,7 +207121,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP]. MP:0005203 - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork @@ -206340,7 +207145,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An trabecular meshwork of the eye - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork @@ -206352,25 +207157,25 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cribiform ligament - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork iridis - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork ligamentum peactin-tum iridis - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork ligamentum pectinatum - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork @@ -206382,7 +207187,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ligamentum pectinatum iridis - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork @@ -206400,38 +207205,38 @@ A continuant cannot be part of an occurrent: use 'participates in'. An reticulum trabeculare sclerae - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork scleral trabeculae - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork scleral trabecular - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork scleral trabecule - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork scribiform ligament - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork trabecular mesh - Wikipedia:Trabecular_meshwork + Wikipedia:Trabecular_meshwork @@ -206571,7 +207376,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:280391002 UMLS:C0008841 Wikipedia:Cisterna_magna - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=542 + neuronames:542 cisterna cerebellomedullaris posterior cisterna magna uberon @@ -206625,6 +207430,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + @@ -206698,7 +207504,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12938 MBA:1056 NLXANAT:20081208 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=667 + neuronames:667 crus I of the ansiform lobule (HVII) crus primum lobuli ansiformis cerebelli [h vii a] first crus of ansiform lobule of cerebellum [hVIIa] @@ -206831,79 +207637,79 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ansiform lobe of the cerebellum, crus 1 - NeuroNames:667 + NeuroNames:667 crus I - NeuroNames:667 + NeuroNames:667 crus I - NeuroNames:667 + NeuroNames:667 crus I (cerebelli) - NeuroNames:667 + NeuroNames:667 crus I of the ansiform lobule - NeuroNames:667 + NeuroNames:667 lobulus posterior superior - NeuroNames:667 + NeuroNames:667 lobulus semilunaris cranialis - NeuroNames:667 + NeuroNames:667 lobulus semilunaris rostralis - NeuroNames:667 + NeuroNames:667 lobulus semilunaris superior - NeuroNames:667 + NeuroNames:667 posterior superior lobule - NeuroNames:667 + NeuroNames:667 semilunar lobule-2 (superior) - NeuroNames:667 + NeuroNames:667 superior semilunar lobule - NeuroNames:667 + NeuroNames:667 @@ -206927,7 +207733,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:12939 MBA:1064 NLXANAT:20081209 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=668 + neuronames:668 crus II of the ansiform lobule (HVII) crus secundum lobuli ansiformis cerebelli [hVII A] hemispheric lobule VIIBi @@ -207542,7 +208348,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber[MP]. - MP:0010566 + MP:0010566 @@ -207574,7 +208380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An left bundle branch - MP:0010566 + MP:0010566 @@ -207586,25 +208392,25 @@ A continuant cannot be part of an occurrent: use 'participates in'. An left bundle of atrioventricular bundle - MP:0010566 + MP:0010566 left crus of atrioventricular bundle - MP:0010566 + MP:0010566 left posterior branch - MP:0010566 + MP:0010566 left posterior bundle - MP:0010566 + MP:0010566 @@ -208358,7 +209164,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An septal leaflet of right-sided tricuspid valve - BGEE:ANiknejad + https://orcid.org/0000-0003-3308-6245 @@ -208555,7 +209361,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The middle part of the hair follicle that extends from the sebaceous duct to the bulge. - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 MP:0010694 @@ -208615,7 +209421,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An postoptic pillar - ISBN:978-0226870137 + ISBN:978-0226870137 @@ -209113,7 +209919,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:279275004 UMLS:C0228120 Wikipedia:Falx_cerebri - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1237 + neuronames:1237 cerebral falx uberon UBERON:0006059 @@ -209586,7 +210392,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000092 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -209694,7 +210500,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -209847,7 +210653,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000724 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -209909,7 +210715,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000082 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -210041,6 +210847,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The base or posterior surface of the urinary bladder contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice. + fundus of bladder EHDAA2:0000582 EHDAA:9330 @@ -210061,6 +210868,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon bladder dome UBERON:0006082 + fundus of urinary bladder @@ -210163,7 +210971,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BIRNLEX:1629 EV:0100182 UMLS:C0004781 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 + neuronames:224 basal nuclei basal nuclei of the forebrain uberon @@ -210189,7 +210997,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224 + neuronames:224 BIRNLEX:1629 @@ -210312,7 +211120,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A funiculus of neuraxis that is part of a spinal cord. FMA:77460 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2760 + neuronames:2760 spinal cord funiculus white column of spinal cord uberon @@ -210378,10 +211186,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system. + neurofibrous BAMS:nfi FMA:5914 - MESH:A08.663.542 + MESH:D009412 SCTID:88545005 Wikipedia:Nervous_system_fiber nerve fibre @@ -210391,6 +211200,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An nerve fibers neurofibra UBERON:0006134 + nerve fiber @@ -210488,7 +211298,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA:2592 EMAPA:16827 VHOG:0000502 - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum aortico-pulmonary septum aorticopulmonary septum septum aorticopulmonale @@ -210518,38 +211328,38 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. MP:0010650 - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum aortico-pulmonary septum - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum aorticopulmonary septum - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum septum aorticopulmonale - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum aortic septum - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum spiral septum - Wikipedia:Aorticopulmonary_septum + Wikipedia:Aorticopulmonary_septum @@ -211404,7 +212214,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EHDAA2 - ISBN:0781772214 + ISBN:0781772214 @@ -212178,7 +212988,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:78456 SCTID:369280006 Wikipedia:Infundibular_recess - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=458 + neuronames:458 infundibular recess infundibular recess of third ventricle recessus infundibularis @@ -212725,7 +213535,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Groove between maxillary prominence and lateral nasal process. Wikipedia:Lacrimal_groove - http://www.indiana.edu/~anat550/hnanim/face/face.html + http://www.indiana.edu/~anat550/hnanim/face/face.html @@ -213481,7 +214291,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced ZFA @@ -214734,6 +215544,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An . + Surface structure that is the region of the head in front of and between the orbits, and above the lower jaw. Nares are located on the snout[ZFA]. EMAPA:32806 MA:0001910 @@ -214789,6 +215600,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood[MP]. + EHDAA2:0001908 EMAPA:17313 FMA:79390 @@ -214801,6 +215613,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon stapedial UBERON:0006345 + stapedial artery @@ -215356,6 +216169,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0003627 EMAPA:32670 FMA:76704 + MESH:D000070616 anulus fibrosus fibrocartilaginous ring uberon @@ -215492,7 +216306,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:83684 MA:0000889 MBA:803 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2673 + neuronames:2673 neuraxis pallidum pallidum of neuraxis uberon @@ -215548,6 +216362,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211). + calyceal calyx EMAPA:18676 @@ -215564,6 +216379,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon calices renales UBERON:0006517 + kidney calyx @@ -215963,11 +216779,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vasculature that is part of a kidney. + EMAPA:28457 TAO:0005305 ZFA:0005305 uberon UBERON:0006544 + kidney vasculature @@ -216185,6 +217003,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pharyngeal FBbt:00005380 MAT:0000049 + MESH:D010614 MIAA:0000049 uberon anterior part of foregut @@ -216214,6 +217033,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A myocardium that is part of a right ventricle of a heart. + Myocardium of ventricle which is continuous with the tunica media of the pulmonary trunk. EMAPA:17342 FMA:9535 @@ -216223,6 +217043,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An right ventricular myocardium uberon UBERON:0006567 + right ventricle myocardium @@ -216387,7 +217208,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:36547 GAID:1183 MA:0002527 - MESH:A12.207.571 + MESH:D007761 NCIT:C33231 UMLS:C1518679 uberon @@ -217525,6 +218346,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity. TODO - check for synonymy between greater and major; branching_part_of relation is made in FMA at level of descending GPA + EMAPA:18754 FMA:49795 MA:0001993 @@ -217534,6 +218356,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon arteria palatina major UBERON:0006664 + greater palatine artery @@ -217602,7 +218425,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -217628,7 +218451,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In mammals, the diaphragm muscle divides the thoracoabdominal cavity into thorax and abdomen. In most mammals, the diaphragm is a flat sheet with muscle fibers radiating outward from a central tendon, and the diaphragm's apposition to the cranial surface of the liver gives it a dome-shape. Muscle fiber contraction reduces the curvature of the dome, thereby expanding the thoracic cavity and aspirating air into the lungs.[well established][VHOG] 2012-09-17 VHOG:0001399 - VHOG + VHOG DOI:10.1016/j.resp.2006.06.003 http://bgee.unil.ch/ @@ -217674,6 +218497,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A valve that is part of a vein. FMA:68095 + MESH:D055422 valve of vein uberon UBERON:0006675 @@ -218002,7 +218826,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0006699 foramen cecum of tongue - Foramen:caecum.png + https://upload.wikimedia.org/wikipedia/commons/a/a3/Foramen_caecum.png @@ -218922,6 +219746,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma. + FMA:63162 MA:0002497 NCIT:C33309 @@ -218936,6 +219761,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon perisinusoidal space UBERON:0006729 + liver perisinusoidal space @@ -219180,7 +220006,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37541 FMA:32851 MA:0003050 - MESH:A02.835.232.500.247.343 + MESH:D005270 NCIT:C32718 SCTID:361791000 UMLS:C0015813 @@ -219392,7 +220218,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Embryologic structure that is formed by two longitudinal eminences, one on each alar plate of the midbrain. These eminences become the superior colliculus and inferior colliculus ( Carpenter-1983 )]. FMA:77488 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1374 + neuronames:1374 lamina quadrigemina quadrigeminal plate uberon @@ -219970,7 +220796,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An scapula - Pectoral:girdles-en.svg + https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg @@ -221250,12 +222076,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane. + MA:0001725 NCIT:C49219 UMLS:C1707351 cervical squamous epithelium uberon UBERON:0006922 + cervix squamous epithelium @@ -221579,9 +222407,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The epithelial cells lining the capsule and trabeculae of the thymus. TODO - check whether this is part of the thymus or borders it + MA:0000769 uberon UBERON:0006936 + thymus subcapsular epithelium @@ -221931,6 +222761,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + CALOHA:TS-1246 EMAPA:28880 FMA:18626 @@ -221947,6 +222778,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon stroma ovarii UBERON:0006960 + ovary stroma @@ -222417,7 +223249,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis - FBbt:00003154 SPD:0000130 TADS:0000147 http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg @@ -222470,7 +223301,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the first set of teeth in the growth development of humans and many other mammals[WP]. FMA:55655 GAID:1266 - MESH:A14.254.860.700 + MESH:D014094 NCIT:C33745 SCTID:245612004 UMLS:C0040455 @@ -222526,7 +223357,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The set of teeth first in order or time of development that will be replaced by permanent dentition upon their loss. FMA:75151 GAID:1252 - MESH:A14.254.245 + MESH:D014094 baby teeth deciduous teeth dentes decidui @@ -222621,7 +223452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An umbilical FMA:61584 GAID:29 - MESH:A01.047.849 + MESH:D014472 NCIT:C77533 SCTID:243961003 UMLS:C0041638 @@ -222684,7 +223515,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward. FMA:42385 GAID:201 - MESH:A02.835.232.500.247.510 + MESH:D005272 NCIT:C61563 SCTID:361792007 UMLS:C0015815 @@ -222749,7 +223580,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An In humans, there are two premolars per quadrant, making eight premolars total in the mouth. They have at least two cusps. Premolars can be considered as a 'transitional tooth' during chewing, or mastication. It has properties of both the anterior canines and posterior molars, and so food can be transferred from the canines to the premolars and finally to the molars for grinding, instead of directly from the canines to the molars. The premolars in humans are the maxillary first premolar, maxillary second premolar, mandibular first premolar, and the mandibular second premolar. There is always one large buccal cusp, especially so in the mandibular first premolar. The lower second premolar almost always presents with two lingual cusps. Premolar teeth by definition are permanent teeth distal to the canines preceded by deciduous molars. In primitive mammals there are four premolars per quadrant. The most mesial two have been lost in Catarrhines. Paleontologists refer to human premolars as Pm3 and Pm4 FMA:55637 GAID:1261 - MESH:A14.254.860.150 + MESH:D001641 NCIT:C32201 SCTID:304572005 UMLS:C1704302 @@ -223706,6 +224537,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins. + EMAPA:18763 FMA:4728 SCTID:303423007 @@ -223714,6 +224546,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vena thyroidea inferioris uberon UBERON:0007156 + inferior thyroid vein @@ -223749,6 +224582,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + UBERON:0004102 FMA:7393 NCIT:C117875 @@ -223758,6 +224592,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon tracheobronchial system UBERON:0007196 + tracheobronchial tree @@ -223921,7 +224756,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000510 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -223983,7 +224818,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-09-17 VHOG:0000511 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -224036,7 +224871,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0007250 lingual tonsil - Illu04:tongue.jpg + https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg @@ -224334,14 +225169,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. VSAO:0005000 - VSAO:NI + VSAO:NI cheiropterygium VSAO:0005000 - VSAO:NI + VSAO:NI @@ -225081,6 +225916,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. TODO - check + In mice many lobules lack islets, in contrast to other mammals including humans EMAPA:37710 FMA:16012 @@ -225090,6 +225926,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pancreatic lobule uberon UBERON:0007324 + pancreatic lobule @@ -225144,6 +225981,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A duct that collects and carries secretions of the exocrine pancreas to the intestine. this class groups together accessory (dorsal) and main (ventral) pancreatic ducts + Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG] in EHDAA2, the dorsal and ventral ducts are classified as epithelial sacs - review after overhaul of duct/epithelia terms @@ -225151,6 +225989,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:32952 FMA:10419 MA:0000124 + MESH:D010183 SCTID:181278006 TAO:0001372 VHOG:0000254 @@ -225161,6 +226000,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon ductus pancreaticus UBERON:0007329 + pancreatic duct @@ -225333,7 +226173,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0007359 ruminant forestomach - Abomasum:(PSF).png + https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png @@ -225380,7 +226220,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An omasum UBERON:0007362 omasum - Abomasum:(PSF).png + https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png @@ -225462,7 +226302,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An paunch UBERON:0007365 rumen - Abomasum:(PSF).png + https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png @@ -225498,7 +226338,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An plurilocular stomach UBERON:0007366 ruminant stomach - Abomasum:(PSF).png + https://upload.wikimedia.org/wikipedia/commons/2/2b/Abomasum_(PSF).png @@ -225842,7 +226682,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C88147 SCTID:362417003 UMLS:C0228515 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1207 + neuronames:1207 uberon cerebellum peduncle UBERON:0007416 @@ -225998,7 +226838,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The space within an epithelial sphere. - EHDAA2:0003079 AEO:0000079 cavity of vesicle uberon @@ -226053,7 +226892,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A closed epithelium with a lumen. - EHDAA2:0003119 AEO:0000119 EHDAA2:0003119 uberon @@ -226096,12 +226934,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:0000144 + EHDAA2:0003144 + uberon + UBERON:0007522 + striated muscle sphincter + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:JB + + + + Mesenchyme with little extracellular matrix. - EHDAA2:0003146 AEO:0000146 EHDAA2:0003146 uberon @@ -226128,7 +226985,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix. - EHDAA2:0003151 AEO:0000151 EHDAA2:0003151 uberon @@ -226156,7 +227012,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Mesenchymal cells that are migrating. this class will be an important part of the NC reorganization - EHDAA2:0003152 AEO:0000152 EHDAA2:0003152 uberon @@ -226178,6 +227033,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A ciliated columnar epithelium that is part of a oviduct. + in FMA, epithelium of uterine tube is a subclass of ciliated columnar epithelium. MA introduces subtypes: ciliated columnar and cuboidal. We map the FMA type according to its relationships, not its label FMA:62016 MA:0001719 @@ -226185,6 +227041,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An epithelium of uterine tube uterine tube epithelium UBERON:0007589 + ciliated columnar oviduct epithelium @@ -226399,7 +227256,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35485 MA:0000933 MBA:275 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2672 + neuronames:2672 lateral septal area uberon lateral septum @@ -226481,7 +227338,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Here the perforant path fibers form synapses onto the distal, apical dendrites of pyramidal cells.[WP] BIRNLEX:1359 FMA:83149 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2456 + neuronames:2456 lacunar-molecular layer of hippocampus stratum hippocampi moleculare et substratum lacunosum stratum lacunosum moleculare @@ -226499,7 +227356,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2456 + neuronames:2456 https://github.com/obophenotype/uberon/issues/1223 @@ -226521,7 +227378,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An stratum lacunosum moleculare BIRNLEX:1359 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2456 + neuronames:2456 @@ -226546,7 +227403,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9203 UMLS:C0040999 Wikipedia:Trigeminal_nerve_nuclei - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2021 + neuronames:2021 trigeminal nuclei uberon nuclei trigemini @@ -226934,21 +227791,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt + FBbt AEO - FBbt + FBbt Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. FBbt:00005426 - JB:DEF http://flybase.org/reports/FBrf0178740.html @@ -226987,7 +227843,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -227261,8 +228117,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BAMS:scpp BIRNLEX:1726 FMA:72495 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1007150190 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=833 + neuronames:1007150190 + neuronames:833 SCPP superior cerebellar peduncle of pons uberon @@ -227300,7 +228156,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=833 + neuronames:833 BIRNLEX:1726 @@ -227541,7 +228397,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MBA:928 SCTID:279384001 SCTID:89649002 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=659 + neuronames:659 cerebellum culmen culmen lobule neuraxis culmen @@ -227689,7 +228545,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed). FMA:75152 GAID:1251 - MESH:A14.254.237 + MESH:D019229 dentes permanentes permanent dentition permanent teeth @@ -228635,7 +229491,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MIAA:0000182 TAO:0000565 VHOG:0000305 - VSAO:0000155 + VSAO:0000155 Wikipedia:Pelvis XAO:0003064 ZFA:0000565 @@ -228667,7 +229523,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature. - VSAO:0000155 + VSAO:0000155 Wikipedia:Pelvis @@ -228693,7 +229549,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Girdle skeleton consisting of a set of bones linking the axial series to the hindlimb/fin skeleton and offering anchoring areas for hindlimb/fin and caudal musculature.[VSAO] 2012-08-14 - VSAO:0000155 + VSAO:0000155 VSAO https://orcid.org/0000-0002-6601-2165 @@ -228717,7 +229573,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pelvic girdle skeleton - VSAO:0000155 + VSAO:0000155 @@ -228735,7 +229591,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pelvic girdle - VSAO:0000155 + VSAO:0000155 @@ -228954,7 +229810,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An TAO still mixes tissue and element - TAO + TAO @@ -229739,7 +230595,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. EMAPA:37234 - FMA:24217 + FMA:24217 MA:0000028 SCTID:362666008 dorsum of thorax @@ -229789,7 +230645,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. - FMA:24217 + FMA:24217 @@ -229801,25 +230657,25 @@ A continuant cannot be part of an occurrent: use 'participates in'. An dorsum of thorax - FMA:24217 + FMA:24217 posterior part of thorax - FMA:24217 + FMA:24217 thoracic back - FMA:24217 + FMA:24217 thoracic part of back - FMA:24217 + FMA:24217 @@ -229831,7 +230687,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An back of thorax - FMA:24217 + FMA:24217 @@ -229857,12 +230713,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The collagen fibers, running from the cementum to the alveolar bone, that suspend a tooth in its socket; they include apical, oblique, horizontal, and alveolar crest fibers, indicating that the orientation of the fibers varies at different levels[http://www.drugs.com/dict/desmodentium.html]. The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. It consist of cells, extracellular compartment of fibers. The cells are fibroblast, epithelial, undifferentiated mesenchymal cells, bone and cementum cells. The extracellular compartment consists of collagen fibers bundles embedded in ground substance. The PDL substance has been estimated to be 70% water and is thought to have a significant effect on the tooth's ability to withstand stress loads[WP][BTO:0001020, Wikipedia:Periodontal_fiber, https://github.com/obophenotype/uberon/issues/21]. FMA treats periodontium and periodontal ligament as the same; it has a separate class desmodentium, which we place here even though it is classified as fetal in FMA - BTO:0001020 + BTO:0001020 CALOHA:TS-0763 EMAPA:35679 FMA:56665 GAID:1259 MA:0002467 + MESH:D010513 SCTID:245775004 Wikipedia:Periodontal_fiber fibra periodontalis @@ -229889,7 +230746,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An periodontal ligament - The:Periodontium.jpg + https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg @@ -229924,7 +230781,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. - BTO:0001020 + BTO:0001020 Wikipedia:Periodontal_fiber https://github.com/obophenotype/uberon/issues/1233 https://github.com/obophenotype/uberon/issues/21 @@ -229978,44 +230835,44 @@ A continuant cannot be part of an occurrent: use 'participates in'. An alveolar periosteum - BTO:0001020 + BTO:0001020 alveolodental ligament - BTO:0001020 + BTO:0001020 alveolodental membrane - BTO:0001020 + BTO:0001020 desmodontium - BTO:0001020 + BTO:0001020 http://www.drugs.com/dict/desmodentium.html odontoperiosteum - BTO:0001020 + BTO:0001020 paradentium - BTO:0001020 + BTO:0001020 peridental membrane - BTO:0001020 + BTO:0001020 @@ -230045,13 +230902,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An peridontal membrane - BTO:0001020 + BTO:0001020 peridontium - BTO:0001020 + BTO:0001020 @@ -230089,6 +230946,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An organic-inorganic composite material produced by some mollusks as an inner shell layer; it is also what makes up pearls. It is very strong, resilient, and iridescent. Nacre is found in some ancient lineages of bivalve gastropod and cephalopod. The inner layer in the great majority of mollusk shells is porcellaneous, not nacreous, frequently resulting in a non-iridescent shine or less commonly in non-nacreous iridescence such as flame structure (e.g. conch pearl). Pearls and the inside layer of pearl oyster and freshwater pearl mussel shells are made of nacre. Many other families of mollusk also have a nacreous inner shell layer, including marine gastropods such as the Haliotidae, the Trochidae and the Turbinidae. Nacre is composed of hexagonal platelets of aragonite (a form of calcium carbonate) 10-20 µm wide and 0.5 µm thick arranged in a continuous parallel lamina. These layers are separated by sheets of organic matrix composed of elastic biopolymers (such as chitin, lustrin and silk-like proteins)[WP]. + MESH:D060734 Wikipedia:Nacre mother of pearl uberon @@ -230207,7 +231065,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them. BTO:0001838 FMA:306006 - MESH:A14.254.900.720 + MESH:D014083 NCIT:C34313 SCTID:53301001 UMLS:C0040442 @@ -230353,7 +231211,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An introitus vaginal introitus vestibule of vagina - vestibulum pudendi UBERON:0008330 vestibule of vagina @@ -230403,11 +231260,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:19970 MP:0011848 + + + + vestibulum pudendi + BTO:0003145 + + vestibulum pudendi MP:0011848 + @@ -230435,12 +231300,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An vestibule of vagina BTO:0003145 - - - - vestibulum pudendi - BTO:0003145 - @@ -230460,7 +231319,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EFO:0001397 FMA:24040 GAID:27 - MESH:A01.047.365 + MESH:D006119 NCIT:C12726 SCTID:243962005 UMLS:C0018246 @@ -230558,7 +231417,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C33326 SCTID:57999000 UMLS:C0230463 - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) galen:SoleOfFoot planta plantar part of foot @@ -230587,7 +231446,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The sole is the bottom of the foot. - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) @@ -230637,36 +231496,55 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pelma - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) planta - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) sole of foot - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) sole of the foot - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) soles of the feet - Wikipedia:Sole_(foot) + Wikipedia:Sole_(foot) + + + + + + + + + + + BTO:0003122 + uberon + UBERON:0008339 + microvascular endothelium + https://github.com/obophenotype/uberon/issues/2186 + + + + @@ -230937,7 +231815,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A ridge of epidermal cells that will form the mammary placodes. - GOC:dph + GOC:dph @@ -231159,7 +232037,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0008571 suprahyoid muscle https://github.com/obophenotype/uberon/issues/697 - Suprahyoid:muscles.png + https://upload.wikimedia.org/wikipedia/commons/5/58/Suprahyoid_muscles.png @@ -232397,7 +233275,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0008788 posterior cranial fossa - Posterior:fossa.png + https://upload.wikimedia.org/wikipedia/commons/c/c2/Posterior_fossa.png @@ -232847,6 +233725,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP]. this is a broad grouping class connecting a number of different analagous organs by their function. We place the insect aedeagus here rather than penis, although this is somewhat arbitrary given the broadness of the current definition Surface structure that is an external structure of a male organism through which sperm is transferred to a female organism during mating.[TAO] @@ -232928,7 +233812,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. GO:0060037 - GOC:dph + GOC:dph @@ -232988,6 +233872,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:36551 FMA:62780 MA:0002534 + MESH:D011663 NCIT:C13273 UMLS:C0034085 Wikipedia:Pulmonary_surfactant @@ -233245,6 +234130,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw. + FMA:6872 SCTID:181110003 Wikipedia:Great_auricular_nerve @@ -233253,6 +234139,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An great auricular greater auricular nerve UBERON:0008833 + great auricular nerve http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray805.png @@ -233584,7 +234471,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon UBERON:0008846 skeletal ligament - Knee:diagram.svg + https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg @@ -234026,7 +234913,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0008858 pyloric canal - Illu:stomach.jpg + https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg @@ -234496,9 +235383,11 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages. + EMAPA:37942 uberon UBERON:0008870 + pulmonary alveolar parenchyma @@ -234555,6 +235444,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the airway consisting of a respiratory bronchiole and all of its branches. + EMAPA:37941 FMA:7313 NCIT:C33426 @@ -234568,6 +235458,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An respiratory lobule uberon UBERON:0008874 + pulmonary acinus @@ -234931,7 +235822,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0008883 osteoid - Active:osteoblasts.jpg + https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg @@ -235016,6 +235907,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. + Subdivision of cardiovascular system which has as its parts the pulmonary arterial and venous tree organs.[FMA] FMA:45621 Wikipedia:Pulmonary_circulation @@ -235023,6 +235915,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pulmonary system uberon UBERON:0008886 + pulmonary vascular system @@ -235378,9 +236271,9 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:242642 GAID:681 MBA:453 - MESH:A08.186.211.730.885.213.670.675 + MESH:D013003 SCTID:279252006 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3241 + neuronames:3241 somatic sensory cortex uberon primary somatic sensory cortex @@ -235475,7 +236368,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000908 MBA:322 NLX:143551 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1350 + neuronames:1350 primary somatosensory cortex (area S1, areas 3,1,2) somatosensory area 1 uberon @@ -235569,7 +236462,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:35756 MA:0000918 MBA:378 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1909 + neuronames:1909 somatosensory area 2 uberon supplemental somatosensory area @@ -236055,16 +236948,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk. + apocrine Mammary glands are modified apocrine glands present in both humans and mice; unlike humans, mice do not have axillary apocrine sweat glands[MGI:anna] BTO:0001162 EMAPA:35141 MA:0003040 + MESH:D001050 SCTID:361698000 Wikipedia:Apocrine true apocrine gland uberon UBERON:0008974 + apocrine gland @@ -236498,6 +237394,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A germinal center that is located in a lymph node. + germinal center BTO:0003671 CALOHA:TS-1269 @@ -236511,6 +237408,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lymph node central zone lymph node nodule UBERON:0009039 + lymph node germinal center @@ -237325,7 +238223,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium. - GOC:dph + GOC:dph GOC:sdb_2009 GOC:tb @@ -238682,7 +239580,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -239517,12 +240415,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A branch of the maxillary artery that is found in the gingiva, premolars, and molars. add child terms + EMAPA:37069 MA:0001913 NCIT:C52848 UMLS:C1706783 uberon UBERON:0009654 + alveolar artery @@ -239556,15 +240456,21 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + labial artery EMAPA:37092 MA:0001987 NCIT:C52947 UMLS:C1708633 - labial artery uberon UBERON:0009657 artery of lip + + + + labial artery + MA:0001987 + @@ -239577,12 +240483,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UMLS:C1708633 ncithesaurus:Labial_Artery - - - - labial artery - MA:0001987 - @@ -240119,12 +241019,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels. + medullary sinus EMAPA:37898 FMA:312359 uberon lymph node medullary sinusoid UBERON:0009744 + Lymph flows into the medullary sinuses from cortical sinuses, and into efferent lymphatic vessels. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells.[WP] lymph node medullary sinus @@ -240155,10 +241057,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node. + medullary cord EMAPA:37897 uberon UBERON:0009745 + lymph node medullary cord @@ -240341,11 +241245,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. + EFO:0002557 EMAPA:26220 uberon UBERON:0009752 + pancreas mesenchyme @@ -240497,7 +241403,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. DOI:10.1371/journal.pone.0099864 GO:0061333 - GOC:dph + GOC:dph GOC:mtg_kidney_jan10 @@ -240873,7 +241779,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop. GO:0060515 - GOC:dph + GOC:dph PMID:18977204 @@ -241048,7 +241954,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region. - MA:th + MA:th https://orcid.org/0000-0002-6601-2165 @@ -241468,6 +242374,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla. + FMA says parenchyma, MP says cortex Their name is potentially misleading -- the 'medullary' refers to their destination, not their location. They are located only in the renal cortex, and not in the renal medulla BTO:0001155 @@ -241479,6 +242386,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An renal medullary ray uberon UBERON:0009883 + medullary ray @@ -241544,6 +242452,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An artery that supplies a renal lobe. + FMA only has the set term EMAPA:37091 FMA:71637 @@ -241558,9 +242467,10 @@ A continuant cannot be part of an occurrent: use 'participates in'. An interlobar arteries of kidney set of interlobar arteries of kidney UBERON:0009885 + interlobar artery - Kidney:PioM.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png @@ -241834,7 +242744,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0009913 renal lobe - Kidney:PioM.png + https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png @@ -242101,11 +243011,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The smooth muscle tissue surrounding the epithelium of the ureter. + EMAPA:28811 ureteral smooth muscle ureteral smooth muscle layer uberon UBERON:0009919 + ureter smooth muscle @@ -242486,13 +243398,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO - CARO + CARO @@ -242714,6 +243626,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum. it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the collection of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done. + All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG] BAMS:BG BIRNLEX:826 @@ -242726,14 +243639,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:4276 MA:0000184 MBA:623 - MESH:A08.186.211.730.885.105 + MESH:D001479 NCIT:C12447 PBA:128012596 PBA:4001 UMLS:C0004781 VHOG:0001696 Wikipedia:Basal_ganglia - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2677 + neuronames:2677 basal ganglia basal ganglia set basal nuclei (basal ganglia) @@ -242744,6 +243657,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An set of basal nuclei subcortical nuclei UBERON:0010011 + collection of basal ganglia @@ -242879,7 +243793,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C12228 SCTID:362094001 UMLS:C0226958 - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue base of tongue pars posterior (dorsum linguae) pars posterior dorsi linguae @@ -242897,7 +243811,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An radix linguae UBERON:0010033 posterior part of tongue - Illu04:tongue.jpg + https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg @@ -242914,7 +243828,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The Posterior tongue, or pharyngeal part, is the part of the tongue behind the terminal sulcus. At its root, it is directed backward, and connected with the hyoid bone by the Hyoglossi and Genioglossi muscles and the hyoglossal membrane; with the epiglottis by three folds (glossoepiglottic) of mucous membrane; with the soft palate by the glossopalatine arches; and with the pharynx by the Constrictores pharyngis superiores and the mucous membrane. It is derived primarily from the third pharyngeal arch. (The second arch has a substantial contribution during fetal development, but this later atrophies. The fourth arch may also contribute, depending upon how the boundaries of the tongue are defined.). - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue @@ -242932,7 +243846,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An base of tongue - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue @@ -242944,7 +243858,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pars posterior dorsi linguae - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue @@ -242988,31 +243902,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An base of the tongue - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue pharyngeal part of the tongue - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue posterior 1/3 of the tongue - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue posterior third of tongue - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue radix linguae - Wikipedia:Posterior_tongue + Wikipedia:Posterior_tongue @@ -243541,7 +244455,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An in NCIT this is glandular - NCIT + NCIT @@ -244026,7 +244940,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid. EMAPA:35759 MA:0002943 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2857 + neuronames:2857 uberon UBERON:0010134 @@ -244066,7 +244980,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid. EMAPA:37741 MA:0002944 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2856 + neuronames:2856 uberon humerosensory circumventricular organ humerosensory system @@ -244310,7 +245224,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0010145 paraurethral gland - Skenes:gland.jpg + https://upload.wikimedia.org/wikipedia/commons/b/b8/Skenes_gland.jpg @@ -244328,7 +245242,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The numerous mucous-secreting glands found in several female mammalian species (including rodents and humans) on the anterior wall of the vagina, around the lower end of the urethra, and possessing a common paraurethral duct which opens (on each side) near the external urethral orifice; they are homologous with the prostate gland in males, have highly variable anatomy, and are believed to be the source of the female ejaculate, a lubricating fluid with a similar consistency to male prostatic fluid that is expelled through the urethra during sexual stimulation; like the male prostate, these glands are susceptible to infection (skenitis), cyst development, and cancer. MGI:anna - MP:0011793 + MP:0011793 @@ -244341,7 +245255,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An female urethral gland EMAPA:29653 - MP:0011793 + MP:0011793 @@ -244353,20 +245267,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skene gland - MP:0011793 + MP:0011793 Skene's gland FMA:20083 - MP:0011793 + MP:0011793 female prostate - MP:0011793 + MP:0011793 PMID:10668204 Wikipedia:Skene%27s_gland @@ -244375,7 +245289,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An para-urethral gland FMA:20083 - MP:0011793 + MP:0011793 @@ -244393,13 +245307,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Guerin's gland - MP:0011793 + MP:0011793 Schueller's gland - MP:0011793 + MP:0011793 @@ -244411,7 +245325,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An U-spot - MP:0011793 + MP:0011793 Wikipedia:Skene%27s_gland @@ -244424,7 +245338,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glandula vestibulares minor - MP:0011793 + MP:0011793 @@ -244829,7 +245743,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An eyebrow - Eyes:chris.jpg + https://upload.wikimedia.org/wikipedia/commons/2/29/Eyes_chris.jpg @@ -247398,7 +248312,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -247466,7 +248380,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - EHDAA2-abduced + EHDAA2-abduced @@ -248795,12 +249709,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex. + EMAPA:35530 FMA:312350 MA:0000743 primary follicle of lymph node uberon UBERON:0010395 + lymph node primary follicle @@ -248825,12 +249741,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Lymphatic vessel that enters the lymph node. The afferent lymph vessels enter at all parts of the periphery of the lymph node, and after branching and forming a dense plexus in the substance of the capsule, open into the lymph sinuses of the cortical part. In doing this they lose all their coats except their endothelial lining, which is continuous with a layer of similar cells lining the lymph paths. + MA:0000748 Wikipedia:File:Illu_lymph_node_structure.png vasa afferentia lymphoglandula vasa afferentia lymphoglandulae uberon UBERON:0010396 + afferent lymphatic vessel @@ -248860,12 +249778,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Lymphatic vessel that exits the lymph node. The efferent lymphatic vessel commences from the lymph sinuses of the medullary portion of the lymph nodes and leave the lymph nodes either to veins or greater nodes. Efferent lymphatic vessels are also found in the thymus and spleen. This is in contrast to afferent lymphatic vessels, which are found only in lymph nodes. + MA:0000749 Wikipedia:Efferent_lymph_vessel uberon efferent lymphatic vessel efferent lymphatic vessels UBERON:0010397 + efferent lymphatic vessel @@ -248953,6 +249873,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the branches of the splenic artery[MP]. + When the splenic artery passes into the trabecula of the spleen and branches, they become known as the trabecular arteries. When these arteries then reach the white pulp, and become covered with Periarteriolar lymphoid sheaths, the name changes again to central arteries (or central arterioles). Branches of the central arteries are given to the red pulp, and these are called penicillar arteries).[Wikipedia] MA:0000759 NCIT:C49775 @@ -248961,6 +249882,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon trabecular artery UBERON:0010399 + spleen trabecular artery @@ -248998,6 +249920,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the veins that feed the splenic vein. + The trabecular veins are the largest veins inside the spleen. It drains the blood collected in the sinuses of the pulp.[Wikipedia] MA:0000760 NCIT:C49779 @@ -249006,6 +249929,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon trabecular vein UBERON:0010400 + spleen trabecular vein @@ -249049,6 +249973,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein. + central arteriole splenic arteriole MA:0000763 @@ -249056,6 +249981,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An splenic central arteriole uberon UBERON:0010401 + spleen central arteriole @@ -249285,6 +250211,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein. + EMAPA:37673 FMA:49583 MA:0002010 @@ -249294,6 +250221,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An angular artery uberon UBERON:0010408 + ocular angle artery @@ -249556,7 +250484,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0002712 MBA:329 NLX:81 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2703 + neuronames:2703 uberon barrel cortex barrel field @@ -249857,7 +250785,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species. - MGI:llw2 + MGI:llw2 MP:0010234 @@ -249898,6 +250826,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it. + germinal center mantle zone mantle zone of germinal center EMAPA:37661 @@ -249911,6 +250840,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon lymph node dark zone UBERON:0010420 + lymph node germinal center mantle zone @@ -249931,7 +250861,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it. MP:MP PMID:25656706 - http://orcid.org/0000-0003-4183-8865/ + http://orcid.org/0000-0003-4183-8865/ https://github.com/obophenotype/uberon/issues/7 https://orcid.org/0000-0001-9990-8331 @@ -249986,6 +250916,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes. + B cell domain of the spleen B lymphocyte domain of the spleen lymphocytic corona @@ -249999,6 +250930,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon spleen mantle zone UBERON:0010421 + spleen B cell corona @@ -250011,13 +250943,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CL:tm + CL:tm The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes. - CL:tm + CL:tm PMID:17495967 https://github.com/obophenotype/uberon/issues/6 @@ -250031,14 +250963,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lymphocytic corona - CL:tm + CL:tm MP:0002360 splenic corona - CL:tm + CL:tm @@ -250068,7 +251000,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An spleen lymphocytic corona - CL:tm + CL:tm MP:0002360 @@ -250081,7 +251013,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An spleen mantle zone - CL:tm + CL:tm MP:0002360 @@ -250294,7 +251226,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An glandular in NCIT; we consider the two NCIT terms synonymous - NCIT + NCIT @@ -250489,7 +251421,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An monotrich hair - DOI:10.1016/j.cub.2008.12.005 + DOI:10.1016/j.cub.2008.12.005 @@ -250580,7 +251512,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. - MESH:A07.231.432 + MESH:D055806 TAO:0005251 ZFA:0005251 uberon @@ -250871,7 +251803,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]. VSAO:0005028 - VSAO:NI + VSAO:NI https://orcid.org/0000-0002-6601-2165 @@ -250885,7 +251817,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An acropodium VSAO:0005028 - VSAO:NI + VSAO:NI @@ -250906,7 +251838,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An AAO:0000946 EMAPA:36158 FMA:71336 - MESH:A02.835.232.087.535 + MESH:D050279 VSAO:0005026 Wikipedia:Metacarpus XAO:0003208 @@ -250928,7 +251860,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An metacarpalia UBERON:0010544 metacarpus skeleton - Metacarpals:numbered-en.svg + https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg @@ -251013,14 +251945,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior metapodium VSAO:0005026 - VSAO:NI + VSAO:NI fore metapodium AAO:0000946 - MA:th + MA:th http://en.wiktionary.org/wiki/metapodial @@ -251148,7 +252080,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An posterior metapodium VSAO:0005027 - VSAO:NI + VSAO:NI @@ -253554,7 +254486,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified]. VSAO:0005029 - VSAO:NI + VSAO:NI https://orcid.org/0000-0002-6601-2165 @@ -253562,7 +254494,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An manual phalanges VSAO:0005029 - VSAO:NI + VSAO:NI @@ -253582,7 +254514,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior acropodium VSAO:0005029 - VSAO:NI + VSAO:NI @@ -253663,7 +254595,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pedal phalanges VSAO:0005030 - VSAO:NI + VSAO:NI @@ -253682,7 +254614,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An posterior acropodium VSAO:0005030 - VSAO:NI + VSAO:NI @@ -253975,7 +254907,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior zeugopodium skeleton VSAO:0005011 - VSAO:NI + VSAO:NI @@ -254003,7 +254935,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior zeugopodium VSAO:0005011 - VSAO:NI + VSAO:NI @@ -254016,13 +254948,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An forelimb epipodium VSAO:0005011 - VSAO:NI + VSAO:NI mesomere 2 of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 @@ -254038,7 +254970,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Anatomical group that consists of the soft and skeletal tissues of the appendicular region of the body and the appendage proper.[VSAO] It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] note that the FMA uses the term 'limb' to refer to the entire appendage complex (free limb plus girdle region) - haendel + 2012-04-23T10:46:51Z EMAPA:37858 FMA:7182 @@ -254344,7 +255276,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Skeletal subdivision that is a segment of the limb skeleton. VSAO:0005018 - VSAO:NI + VSAO:NI @@ -254587,13 +255519,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An hindlimb epipodium VSAO:0005014 - VSAO:NI + VSAO:NI mesomere 2 of pelvic appendage - ISBN:0226313409 + ISBN:0226313409 @@ -255010,7 +255942,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An SCTID:362879001 UMLS:C0228116 Wikipedia:Meninges - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1465 + neuronames:1465 cerebral meninges cluster of meninges meninges @@ -255367,11 +256299,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A secondary follicle that is located in a lymph node. + EMAPA:35531 FMA:312352 MA:0000744 uberon UBERON:0010753 + lymph node secondary follicle @@ -255417,7 +256351,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0010754 A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.[GO] germinal center - Germinal:center.svg + https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg @@ -256803,7 +257737,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0010933 orbicularis oris muscle https://github.com/obophenotype/uberon/issues/473 - Orbicularis:oris.jpg + https://upload.wikimedia.org/wikipedia/commons/b/b6/Orbicularis_oris.jpg @@ -256876,7 +257810,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An belly venter FMA:9719 - STID:29823001 + SCTID:29823001 belly of muscle uberon UBERON:0010938 @@ -257002,7 +257936,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0010952 frontalis muscle belly - Musculus:frontalis.png + https://upload.wikimedia.org/wikipedia/commons/b/be/Musculus_frontalis.png @@ -257572,6 +258506,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints. + AEO:0000179 BTO:0001572 CALOHA:TS-0055 @@ -257580,7 +258515,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:12264 GAID:101 MA:0000487 - MESH:A02.165.165 + MESH:D002358 NCIT:C32144 SCTID:305026006 UMLS:C0007303 @@ -257592,6 +258527,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An joint-associated cartilage UBERON:0010996 + @@ -257859,7 +258795,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -257874,8 +258810,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] 2012-09-17 VHOG:0000511 - VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + VHOG + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) http://bgee.unil.ch/ @@ -259241,7 +260177,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - FBbt + FBbt @@ -260704,14 +261640,14 @@ A continuant cannot be part of an occurrent: use 'participates in'. An mesomere 2 - ISBN:0226313409 + ISBN:0226313409 mesomere 2 skeleton - ISBN:0226313409 + ISBN:0226313409 @@ -262167,6 +263103,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + EHDAA2:0004149 FMA:85125 uberon @@ -262176,6 +263113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An atrioventricular junction atrioventricular segment UBERON:0011820 + atrioventricular region @@ -262913,7 +263851,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Fluid of the ganglia and peripheral nerves that lie outside the brain and spinal cord. - MGI:llw2 + MGI:llw2 MP:0003633 @@ -263157,7 +264095,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs. FMA:5924 - MESH:A08.663.542.100 + MESH:D001338 NCIT:C12648 UMLS:C0004384 Wikipedia:Postganglionic_nerve_fibers @@ -263201,7 +264139,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released. FMA:5923 - MESH:A08.663.542.122 + MESH:D001339 NCIT:C12624 Wikipedia:Preganglionic_nerve_fibers preganglionic nerve fiber @@ -263237,7 +264175,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cholinergic axonal fiber projecting from a parasympathetic ganglion to an effector organ. - MESH:A08.663.542.100.700 + MESH:D017777 NCIT:C12649 UMLS:C0206252 Wikipedia:Postganglionic_fibers @@ -263417,7 +264355,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A pilosebaceuous unit that contains a strand of virbissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves. + A pilosebaceous unit that contains a strand of vibrissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves. + MA has distinct classes for vibrissa and vibrissa hair - the former includes the follicle and is thus not the hair proper. We model this as the 'vibrissa unit' EMAPA:17529 MA:0000163 @@ -263430,7 +264369,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - A pilosebaceuous unit that contains a strand of virbissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves. + A pilosebaceous unit that contains a strand of vibrissa hair (a specialized tactile hair) with the follicle incorporating a blood sinus, heavily innervated by sensory nerves. http://orcid.org/0000-0002-6601-2165 @@ -263974,7 +264913,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Many species of mammals have diastemata as a normal feature, most commonly between the incisors and molars UBERON:0013134 FMA:77271 - MESH:A14.254.333 + MESH:D003970 SCTID:410003009 Wikipedia:Diastema_(dentistry) interdental space @@ -264547,6 +265486,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP]. + EMAPA:28679 bladder vasculature blood vessels of bladder @@ -264554,6 +265494,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uberon blood vessel of bladder UBERON:0012239 + urinary bladder vasculature @@ -264888,6 +265829,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + EMAPA:35308 FMA:86488 MA:0002732 @@ -264896,6 +265838,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An uterine glands set uberon UBERON:0012276 + endometrium glandular epithelium @@ -265606,6 +266549,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux. TODO - add relationship to junction + FMA:77047 NCIT:C12337 SCTID:181415004 @@ -265621,6 +266565,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ureterovesical orifice uberon UBERON:0012303 + ureteral orifice @@ -265628,7 +266573,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux. - MP:0011783 + MP:0011783 Wikipedia:Orifice_of_ureter @@ -265647,7 +266592,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An orificium ureteris - MP:0011783 + MP:0011783 @@ -265660,20 +266605,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ostium ureteris - MP:0011783 + MP:0011783 ureteral meatus - MP:0011783 + MP:0011783 ureteral opening - MP:0011783 + MP:0011783 @@ -265685,7 +266630,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ureteric orifice - MP:0011783 + MP:0011783 @@ -265703,7 +266648,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An ureterovesical orifice - MP:0011783 + MP:0011783 @@ -265812,7 +266757,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One of five swellings formed during the development of the face. - http://www.indiana.edu/~anat550/hnanim/face/face.html + http://www.indiana.edu/~anat550/hnanim/face/face.html @@ -265912,6 +266857,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP]. + FMA:49986 SCTID:312160004 Wikipedia:Anterior_ethmoidal_artery @@ -265922,6 +266868,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An anterior meningeal arteries anterior meningeal artery UBERON:0012318 + anterior ethmoidal artery @@ -266027,6 +266974,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis. + FMA:16516 MESH:D001956 NCIT:C12318 @@ -266038,6 +266986,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An broad ligament ligamentum latum uteri UBERON:0012332 + broad ligament of uterus @@ -266571,6 +267520,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A muscular coat that is part of a jejunum. + FMA:14951 muscularis externa of jejunum uberon @@ -266578,6 +267528,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An muscularis propria of jejunum smooth muscle of jejunum UBERON:0012377 + muscle layer of jejunum @@ -266625,6 +267576,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A muscular coat that is part of a urinary bladder. + FMA:15930 NCIT:C32206 UMLS:C1288327 @@ -266638,6 +267590,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An tunica muscularis (vesica urinaria) uberon UBERON:0012378 + muscle layer of urinary bladder @@ -266749,7 +267702,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - DOI:10.1177/0192623311409597 + DOI:10.1177/0192623311409597 @@ -266778,7 +267731,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A sensory receptor that responds to mechanical pressure or distortion. FMA:86587 - MESH:A08.800.550.700.500 + MESH:D008465 NCIT:C13821 Wikipedia:Mechanoreceptor uberon @@ -266810,7 +267763,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C13171 SCTID:41421000 UMLS:C0205831 - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle uberon Dogiel's end bulb Ruffini's end bulb @@ -266836,7 +267789,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A type of nerve ending in the skin that is responsible for sensitivity to light touch. In particular, they have highest sensitivity (lowest threshold) when sensing vibrations lower than 50 Hertz. They are rapidly adaptive receptors. - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle @@ -266860,49 +267813,49 @@ A continuant cannot be part of an occurrent: use 'participates in'. An meisner's corpuscle - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle meissner corpuscle - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle meissner corpuscle end-organ - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle meissner's corpuscle - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle meissner's corpuscles - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle messier corpuscle - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle messner's corpuscle - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle tactile corpuscles of Wagner and Meissner - Wikipedia:Meissner%27s_corpuscle + Wikipedia:Meissner%27s_corpuscle @@ -266913,7 +267866,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A sensory nerve ending that responds to a stimulus in the internal or external environment of an organism. In response to stimuli the sensory receptor initiates sensory transduction by creating graded potentials or action potentials in the same cell or in an adjacent one. FMA:84650 - MESH:A08.800.550.700 + MESH:D011984 NCIT:C13819 SCTID:70402007 UMLS:C0682664 @@ -267099,68 +268052,68 @@ A continuant cannot be part of an occurrent: use 'participates in'. An corpusculum sensorium fusiforme - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini corpuscle - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini corpuscle end-organ - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini corpuscles - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini endings - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini's corpuscles - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini's end organ - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini's ending - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending Ruffini's organs - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending bulbous corpuscle - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending corpuscle of ruffini - Wikipedia:Ruffini_ending + Wikipedia:Ruffini_ending @@ -267688,7 +268641,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCIT:C32292 SCTID:279337001 Wikipedia:Sulcus_(neuroanatomy) - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1208 + neuronames:1208 cerebral sulci fissure of brain uberon @@ -267968,7 +268921,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Note that some sources may treat the term vesicle as the progenitor of the whole brain region; for example 'The retina develops directly from the neural tube as an outpouching from the diencephalic vesicle' NCIT:C34259 SCTID:360409004 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2499 + neuronames:2499 early brain vesicle primitive brain vesicle primary brain vesicle @@ -268049,6 +269002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles. + EMAPA:37927 FMA:18613 NCIT:C33243 @@ -268057,6 +269011,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An cortex ovarii (zona parenchymatosa) uberon UBERON:0013191 + ovarian cortex @@ -268988,79 +269943,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - - - - - - - A segmentation of the cerebral cortex on the basis of cytoarchitecture as described in Brodmann-1905, Brodmann-1909 and Brodmann-10. Maps for several species were presented. NeuroNames includes only areas in the human and in Old World monkeys. Of the latter, Brodmann studied representatives of several species including guenons (one Cercopithecus mona, one Cercocebus torquatus, and one Cercopithecus otherwise unspecified), which are all closely related African species, and one macaque (Macaca mulatta) an Asian species (Brodmann-1905). The legend to the summary map in Brodmann-1909 ascribes the areas simply to Cercopithecus. Brodmann referenced the areas by name and number. The same area number in humans and monkeys did not necessarily refer to topologically or cytoarchitecturally homologous structures. In NeuroNames the standard term for human areas consists of the English translation of Brodmann's Latin name followed by the number he assigned, e.g., agranular frontal area 6; the standard terms for monkey areas are in the format: area 6 of Brodmann-1909. He mapped a portion of areas limited to the banks of sulci, e.g., area 3 of Brodmann-1909 (Brodmann-1909) onto the adjacent, visible surface. This accounts for the fact that some areas appear larger on his surface map than on maps of other authors, e.g., area 3 of Vogts-1919. (Adapted from NeuroNames). - BAMS:VTM - BIRNLEX:1731 - FMA:68596 - NCIT:C94868 - SCTID:384717008 - Wikipedia:Brodmann_area - WikipediaCategory:Brodmann_areas - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1032 - uberon - Brodmann parcellation scheme region - Brodmann partition scheme region - Brodmann's areas - UBERON:0013529 - Brodmann area - - - - - - - - - - - FMA - Wikipedia - - - - - A segmentation of the cerebral cortex on the basis of cytoarchitecture as described in Brodmann-1905, Brodmann-1909 and Brodmann-10. Maps for several species were presented. NeuroNames includes only areas in the human and in Old World monkeys. Of the latter, Brodmann studied representatives of several species including guenons (one Cercopithecus mona, one Cercocebus torquatus, and one Cercopithecus otherwise unspecified), which are all closely related African species, and one macaque (Macaca mulatta) an Asian species (Brodmann-1905). The legend to the summary map in Brodmann-1909 ascribes the areas simply to Cercopithecus. Brodmann referenced the areas by name and number. The same area number in humans and monkeys did not necessarily refer to topologically or cytoarchitecturally homologous structures. In NeuroNames the standard term for human areas consists of the English translation of Brodmann's Latin name followed by the number he assigned, e.g., agranular frontal area 6; the standard terms for monkey areas are in the format: area 6 of Brodmann-1909. He mapped a portion of areas limited to the banks of sulci, e.g., area 3 of Brodmann-1909 (Brodmann-1909) onto the adjacent, visible surface. This accounts for the fact that some areas appear larger on his surface map than on maps of other authors, e.g., area 3 of Vogts-1919. (Adapted from NeuroNames). - BIRNLEX:1731 - - - - - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1032 - tgbugs - - - - - Brodmann parcellation scheme region - BIRNLEX:1731 - - - - - Brodmann partition scheme region - BIRNLEX:1731 - - - - - Brodmann's areas - BIRNLEX:1731 - - - - - @@ -269080,7 +269962,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An DMBA:16093 MBA:254 Wikipedia:Retrosplenial_region - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2436 + neuronames:2436 uberon retrosplenial area retrosplenial cortex @@ -270097,12 +270979,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - A blood that is part of a artery. FMA:83066 arterial blood @@ -270144,12 +271020,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - A blood that is part of a vein. FMA:83067 blood in vein @@ -270190,12 +271060,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - A blood that is part of a capillary. FMA:263901 NCIT:C32212 @@ -271212,6 +272076,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Muscle that is part of the respiratory system. this class may be merged with 'respiratory system muscle'; check intercostals + MESH:D012132 uberon UBERON:0014398 @@ -271552,7 +272417,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An HBA:9083 SCTID:416164009 UMLS:C0175358 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=468 + neuronames:468 nucleus of pretectal area pretectal area nucleus pretectal nucleus @@ -271597,7 +272462,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=468 + neuronames:468 BIRNLEX:864 @@ -272057,31 +272922,31 @@ A continuant cannot be part of an occurrent: use 'participates in'. An coffin bone - NCBITaxon:9787 + NCBITaxon:9787 medial claw of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 medial claw of ruminant hoof - NCBITaxon:91561 + NCBITaxon:91561 medial ungual phalanx of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 pedal bone - NCBITaxon:9787 + NCBITaxon:9787 @@ -272144,19 +273009,19 @@ A continuant cannot be part of an occurrent: use 'participates in'. An lateral claw of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 lateral claw of ruminant hoof - NCBITaxon:91561 + NCBITaxon:91561 lateral ungual phalanx of artiodactyl - NCBITaxon:91561 + NCBITaxon:91561 @@ -272915,7 +273780,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:0004005 DHBA:12390 Wikipedia:Cerebellum - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2128 + neuronames:2128 cerebellum lateral hemisphere cerebellum lateral zone neocerebellum @@ -272981,7 +273846,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:72256 HBA:12936 NLXANAT:20081261 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=664 + neuronames:664 hemisphere of posterior lobe hemisphere of posterior lobe of cerebellum hemispherium lobus posterior @@ -273034,7 +273899,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BIRNLEX:1024 BIRNLEX:1414 FMA:83944 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=778 + neuronames:778 substantia alba medullae oblongatae white matter of medulla white substance of medulla @@ -273080,10 +273945,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + FMA:49695 SCTID:276151008 uberon UBERON:0014693 + inferior alveolar artery @@ -273100,11 +273967,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + NCIT:C32828 UMLS:C1512857 Wikipedia:Interlobular_ducts uberon UBERON:0014716 + interlobular duct @@ -273791,7 +274660,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37870 FMA:72510 MBA:1116 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=581 + neuronames:581 genu nervi facialis internal genu of facial nerve uberon @@ -273928,7 +274797,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An EMAPA:37947 MBA:886 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1802 + neuronames:1802 uberon retrosplenial area, ventral part retrosplenial cortex, ventral part @@ -277244,6 +278113,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A corkscrew-like artery in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change). + In women, rats and mice, the endometrial vessels are coiled and known as spiral arteries[PMID:16413937]. spiral artery BTO:0003371 @@ -277258,6 +278128,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An spiral arteries spiral artery UBERON:0015171 + uterine spiral artery @@ -277315,10 +278186,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A blood vessel that is part of a endometrium. + SCTID:254200009 blood vessel of endometrium uberon UBERON:0015172 + endometrial blood vessel @@ -277430,12 +278303,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - Any structure that is placed on one side of the left-right axis of a bilaterian. This class is primarily to implement taxon constraints. It may be removed in the future. uberon @@ -279129,7 +279996,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An OpenCyc:Mx4rvViwtJwpEbGdrcN5Y29ycA UMLS:C0587901 Wikipedia:Auditory_system - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2888 + neuronames:2888 uberon UBERON:0016490 auditory system @@ -279233,6 +280100,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border. Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though + frontal region regio frontalis BAMS:Frontal_lobe @@ -279245,19 +280113,20 @@ A continuant cannot be part of an occurrent: use 'participates in'. An FMA:61824 HBA:4009 MAT:0000505 - MESH:A08.186.211.730.885.213.270 + MESH:D005625 NCIT:C12352 OpenCyc:Mx4rv3OJ8JwpEbGdrcN5Y29ycA SCTID:180920004 UMLS:C0016733 UMLS:C1268977 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=56 + neuronames:56 lobi frontales lobus frontalis frontal cortex uberon UBERON:0016525 + frontal lobe @@ -279320,7 +280189,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=56 + neuronames:56 BIRNLEX:928 @@ -279365,7 +280234,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BTO:0000445 FMA:61823 SCTID:272632001 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1210 + neuronames:1210 cerebral hemisphere lobe cerebral lobe lobe of cerebral cortex @@ -279516,7 +280385,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An MA:0000916 NLX:79282 SCTID:369217001 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2473 + neuronames:2473 cortex of parietal lobe parietal lobe cortex parietal neocortex @@ -279559,57 +280428,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - - - - - - DHBA:10268 - DMBA:16030 - EMAPA:35604 - FMA:242205 - MA:0000913 - PBA:4004 - cortex of occipital lobe - occipital lobe cortex - occipital neocortex - uberon - gray matter of occipital lobe - UBERON:0016540 - occipital cortex - - - - - cortex of occipital lobe - FMA:242205 - - - - - occipital lobe cortex - FMA:242205 - - - - - occipital neocortex - DHBA:10268 - - - - - gray matter of occipital lobe - FMA:242205 - - - - @@ -279904,7 +280722,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An jPL (SMC) FMA:224858 Wikipedia:Supplementary_motor_area - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3176 + neuronames:3176 uberon SMA proper area F3 @@ -280158,6 +280976,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints. + MESH:D012785 SCTID:361835002 joint of shoulder region uberon @@ -280991,7 +281810,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex. may be replaced by a GO process in future FMA:74787 - MESH:G06.535.805 + MESH:D012084 uberon renin angiotensin aldosterone system renin angiotensin system @@ -281272,7 +282091,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An NCITA class may refer to smooth muscle only - NCIT + NCIT @@ -281389,7 +282208,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A sensory receptor that detects chemical stimulus within the body. Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. FMA:85604 - MESH:A08.800.550.700.120 uberon UBERON:0018391 chemoreceptor @@ -282746,10 +283564,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A white matter that is part of the hindbrain. + DHBA:10668 FMA:268636 uberon UBERON:0019258 + white matter of hindbrain @@ -282772,10 +283592,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A white matter that is part of the forebrain. + DHBA:10557 FMA:268634 uberon UBERON:0019261 + white matter of forebrain @@ -282829,11 +283651,13 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + DHBA:10654 FMA:268630 gray matter of the hindbrain uberon UBERON:0019263 + gray matter of hindbrain @@ -282855,10 +283679,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + DHBA:10157 FMA:268608 uberon UBERON:0019264 + gray matter of forebrain @@ -282874,10 +283700,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + DHBA:10649 FMA:83913 uberon UBERON:0019267 + gray matter of midbrain @@ -283684,10 +284512,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + EMAPA:37958 SCTID:181098007 uberon UBERON:0034729 + sympathetic nerve @@ -283876,7 +284706,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland. - EMAPA:16647 EHDAA2:0004434 EMAPA:16647 uberon @@ -283987,7 +284816,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -284019,7 +284848,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -284036,6 +284865,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. CARO:0020000 + FBbt:00007276 uberon UBERON:0034923 disconnected anatomical group @@ -284044,7 +284874,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - CARO + CARO @@ -284246,7 +285076,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - VHOG + VHOG @@ -284321,7 +285151,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A cluster of chemoreceptive and support cells associated with blood vessels and nerves. - MESH:A08.800.550.700.120.600 + MESH:D010234 uberon UBERON:0034979 nonchromaffin paraganglion @@ -284489,7 +285319,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cellular receptors which mediate the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and NOCICEPTORS which detect cold or heat extreme enough to cause pain. - MESH:A08.800.550.700.840 + MESH:D013823 NCIT:C13822 UMLS:C0039821 uberon @@ -285172,6 +286002,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + FMA:225275 superficial part of circulatory system superficial vasculature @@ -285182,6 +286013,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An subcutaneous vasculature vasculature of skin UBERON:0035549 + vasculature of integument @@ -285510,7 +286342,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any nerve that innervates the larynx. - MESH:A08.800.050.050.925.450 + MESH:D007823 SCTID:307013006 uberon UBERON:0035642 @@ -285584,7 +286416,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches. EMAPA:36511 - MESH:A08.800.800.720.450.760.640 + MESH:D010543 peroneal nerve uberon UBERON:0035652 @@ -285661,12 +286493,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - FMA:12241 SCTID:304404008 uberon @@ -285774,7 +286600,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A skeletal projection in the chondrocranium that developmentally connects the orbital cartilage and may develop into bone regions. - ISBN:978-0226870137 + ISBN:978-0226870137 UBERON:cjm @@ -285837,8 +286663,8 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. - BGEE:ann http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1 + https://orcid.org/0000-0003-3308-6245 @@ -285876,12 +286702,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An - - - - - - Material anatomical entity that forms the outermost boundary of an anatomical structure. AAO:0010270 AEO:0000154 @@ -285939,7 +286759,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An pyramidal tract BIRNLEX:1464 MP:0002878 - http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1320 + neuronames:1320 @@ -286175,6 +286995,30 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + + + + + + FMA:322073 + uberon + UBERON:0039175 + subarachnoid space of brain + + + + + + FMA + + + + @@ -286186,7 +287030,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A zone of skin that is part of the face. - eriks + 2012-02-05T05:23:01Z EMAPA:36657 FMA:24758 @@ -286236,6 +287080,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages. + EMAPA:35805 FMA:15845 MA:0002487 @@ -286247,6 +287092,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An splenic pulp uberon UBERON:1000023 + spleen pulp @@ -286319,7 +287165,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An An anatomical junction between two parts of the digestive tract. - + 2021-02-05T11:19:31Z uberon UBERON:1100000 @@ -286339,7 +287185,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - teleost_anatomy_curators ZFA:0000555 gill cover opercular apparatus @@ -286348,6 +287193,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An UBERON:2000555 opercular flap + + + + This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/tao.owl + @@ -286433,12 +287284,17 @@ A continuant cannot be part of an occurrent: use 'participates in'. An This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - teleost_anatomy_curators ZFA:0001431 uberon UBERON:2001431 primitive olfactory epithelium + + + + This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/tao.owl + @@ -286454,7 +287310,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cartilage which is part of the axial skeleton. This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - teleost_anatomy_curators ZFA:0001457 uberon UBERON:2001457 @@ -286466,6 +287321,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Cartilage which is part of the axial skeleton. ZFIN:curator + + + + This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/tao.owl + @@ -286475,7 +287336,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Tooth that is attached to the premaxilla. This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - teleost_anatomy_curators uberon UBERON:2001626 premaxillary tooth @@ -286486,6 +287346,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Tooth that is attached to the premaxilla. TAO:wd + + + + This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/tao.owl + @@ -286555,7 +287421,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - teleost_anatomy_curators ZFA:0007013 uberon UBERON:2007013 @@ -286567,6 +287432,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. ZFIN:curator + + + + This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/tao.owl + @@ -286582,7 +287453,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - amphibian_anatomy_curators uberon UBERON:3000961 Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 @@ -286594,6 +287464,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. AAO:EJS + + + + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/aao.owl + @@ -286609,7 +287485,6 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Dermal, epidermal, glandular and pigment structures of the limb integument. This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon - amphibian_anatomy_curators uberon UBERON:3000981 limb external integument structure @@ -286620,6 +287495,46 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Dermal, epidermal, glandular and pigment structures of the limb integument. AAO:EJS + + + + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/aao.owl + + + + + + + + + + + + + + + Anatomical system that has as its parts the organs concerned with reproduction, especially the external genital organs. + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + genitalia + reproductive system + uberon + UBERON:3011048 + genital system + + + + + Anatomical system that has as its parts the organs concerned with reproduction, especially the external genital organs. + XAO:0000142 + https://www.merriam-webster.com/dictionary/genitalia + + + + + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + http://purl.obolibrary.org/obo/aao.owl + @@ -288694,7 +289609,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. - http://orcid.org/0000-0001-5208-3432 + Purkinje fibre network uberon UBERON:8000009 @@ -288736,10 +289651,73 @@ A continuant cannot be part of an occurrent: use 'participates in'. An + + + + + + + + + + + + + A submucosal gland found in a respiratory tract. + + 2022-03-24T14:21:59Z + EFO:0010666 + respiratory tract submucosal gland + submucosal gland of respiratory tract + uberon + UBERON:8410077 + airway submucosal gland + + + + + A submucosal gland found in a respiratory tract. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. + microvascular + http://orcid.org/0000-0002-2825-0621 + microvasculature + microvessel + uberon + UBERON:8410081 + blood microvessel + https://github.com/obophenotype/uberon/issues/2186 + + + + + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. + Wikipedia:Microcirculation + http://orcid.org/0000-0002-7073-9172 + + + + + + + + + + One or a subset of adjacent layers of the neocortex. uberon UBERON:8440004 @@ -288751,6 +289729,78 @@ A continuant cannot be part of an occurrent: use 'participates in'. An One or a subset of adjacent layers of the neocortex. ISBN-10:0-87893-742-0 + + + + + + + + + + + + + + + The part of the cortex that is responsible for processing visual information. + + uberon + UBERON:8440011 + cortical visual area + + + + + The part of the cortex that is responsible for processing visual information. + https://orcid.org/0000-0001-7258-9596 + + + + + + + + + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). + uberon + UBERON:8440015 + noradrenergic cell groups + + + + + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). + WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184 + + + + + + + + + + + + + + + + An individual reproductive unit containing a single oocyte and one or several layers of support cells (Armstrong et al., 2020). + + 2022-04-19T11:08:10Z + uberon + UBERON:8450001 + egg follicle + https://github.com/obophenotype/uberon/issues/476 + + + + + An individual reproductive unit containing a single oocyte and one or several layers of support cells (Armstrong et al., 2020). + DOI:10.1530/REP-18-0593 + diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl index a94be2ea..a364fb4f 100644 --- a/src/patterns/definitions.owl +++ b/src/patterns/definitions.owl @@ -11839,8 +11839,8 @@ EquivalentClasses( ObjectIntersectio # Class: (follicle cell microvillus length) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The microvillus length of a ovarian follicle cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "microvillus length of ovarian follicle cell"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The microvillus length of a follicle cell of egg chamber."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "microvillus length of follicle cell of egg chamber"^^xsd:string) AnnotationAssertion(rdfs:label "follicle cell microvillus length"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -25186,11 +25186,11 @@ AnnotationAssertion(Annotation( "external ear spatial pattern"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (pericyte cell morphology) +# Class: (pericyte morphology) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a pericyte cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of pericyte cell"^^xsd:string) -AnnotationAssertion(rdfs:label "pericyte cell morphology"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a pericyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of pericyte"^^xsd:string) +AnnotationAssertion(rdfs:label "pericyte morphology"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (photoreceptor layer of retina deviation (from_normal)) @@ -28252,11 +28252,11 @@ AnnotationAssertion(Annotation( "Peyer's patch amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (glomerular visceral epithelial cell amount) +# Class: (podocyte amount) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The amount of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "amount of glomerular visceral epithelial cell"^^xsd:string) -AnnotationAssertion(rdfs:label "glomerular visceral epithelial cell amount"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The amount of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "amount of podocyte"^^xsd:string) +AnnotationAssertion(rdfs:label "podocyte amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (podocyte foot amount) @@ -36260,11 +36260,11 @@ AnnotationAssertion(Annotation( "ureter amount"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (visceral layer of glomerular capsule morphology) +# Class: (glomerular visceral epithelium morphology) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a visceral layer of glomerular capsule."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of visceral layer of glomerular capsule"^^xsd:string) -AnnotationAssertion(rdfs:label "visceral layer of glomerular capsule morphology"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a glomerular visceral epithelium."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of glomerular visceral epithelium"^^xsd:string) +AnnotationAssertion(rdfs:label "glomerular visceral epithelium morphology"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glomerular parietal epithelium morphology) @@ -46221,11 +46221,11 @@ AnnotationAssertion(Annotation( "skeletal system development quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (glomerular visceral epithelial cell quality) +# Class: (podocyte quality) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of glomerular visceral epithelial cell"^^xsd:string) -AnnotationAssertion(rdfs:label "glomerular visceral epithelial cell quality"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The quality of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "quality of podocyte"^^xsd:string) +AnnotationAssertion(rdfs:label "podocyte quality"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (avoidance learning behavior quality) @@ -49306,13 +49306,13 @@ AnnotationAssertion( "age of onset of major depressive disorder"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (trait in response to http://purl.obolibrary.org/obo/CHEBI_6809) +# Class: (trait in response to methamphetamine) -AnnotationAssertion( "A trait that affects the response to a stimulus with http://purl.obolibrary.org/obo/CHEBI_6809."^^xsd:string) +AnnotationAssertion( "A trait that affects the response to a stimulus with methamphetamine."^^xsd:string) AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) -AnnotationAssertion( "response to http://purl.obolibrary.org/obo/CHEBI_6809 trait"^^xsd:string) -AnnotationAssertion(rdfs:label "trait in response to http://purl.obolibrary.org/obo/CHEBI_6809"^^xsd:string) +AnnotationAssertion( "response to methamphetamine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to methamphetamine"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) # Class: (trait in response to cocaine) @@ -49324,13 +49324,13 @@ AnnotationAssertion( "trait in response to cocaine"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) -# Class: (trait in response to http://purl.obolibrary.org/obo/CHEBI_18723) +# Class: (trait in response to nicotine) -AnnotationAssertion( "A trait that affects the response to a stimulus with http://purl.obolibrary.org/obo/CHEBI_18723."^^xsd:string) +AnnotationAssertion( "A trait that affects the response to a stimulus with nicotine."^^xsd:string) AnnotationAssertion( "https://orcid.org/0000-0001-8314-2140"^^xsd:string) AnnotationAssertion( "https://orcid.org/0000-0002-7073-9172"^^xsd:string) -AnnotationAssertion( "response to http://purl.obolibrary.org/obo/CHEBI_18723 trait"^^xsd:string) -AnnotationAssertion(rdfs:label "trait in response to http://purl.obolibrary.org/obo/CHEBI_18723"^^xsd:string) +AnnotationAssertion( "response to nicotine trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to nicotine"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) # Class: (mammary gland secreted fluid morphology trait) @@ -59793,8 +59793,8 @@ EquivalentClasses( ObjectIntersect # Class: (podocyte morphology trait) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a glomerular visceral epithelial cell."^^xsd:string) -AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of glomerular visceral epithelial cell"^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "The morphology of a podocyte."^^xsd:string) +AnnotationAssertion(Annotation( "AUTO:patterns/patterns/entity_attribute"^^xsd:string) "morphology of podocyte"^^xsd:string) AnnotationAssertion(rdfs:label "podocyte morphology trait"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) diff --git a/src/patterns/pattern.owl b/src/patterns/pattern.owl index 3c7a2530..0b5792ad 100644 --- a/src/patterns/pattern.owl +++ b/src/patterns/pattern.owl @@ -12,7 +12,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -24,12 +24,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) @@ -71,7 +73,7 @@ AnnotationAssertion( "age 'disease' symptoms begin"^^xsd:string) AnnotationAssertion( "age at onset of 'disease'"^^xsd:string) AnnotationAssertion(rdfs:label "age of onset of 'disease'"^^xsd:string) -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: ('thing' 'quality') @@ -97,14 +99,24 @@ AnnotationAssertion(Annotation( "'quality' of 'process' in 'thing'"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( owl:Thing))))) -# Class: (trait in response to 'chemical entity') +# Class: (trait in response to 'chemical_entity') -AnnotationAssertion( "A trait that affects the response to a stimulus with 'chemical entity'."^^xsd:string) +AnnotationAssertion( "A trait that affects the response to a stimulus with 'chemical_entity'."^^xsd:string) +AnnotationAssertion( "xsd:anyURI"^^xsd:string) AnnotationAssertion( "response_to_chemical_stimulus_trait"^^xsd:string) -AnnotationAssertion( "response to 'chemical entity' trait"^^xsd:string) -AnnotationAssertion(rdfs:label "trait in response to 'chemical entity'"^^xsd:string) +AnnotationAssertion( "response to 'chemical_entity' trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 'chemical_entity'"^^xsd:string) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) +# Class: (trait in response to 'role') + +AnnotationAssertion( "A trait that affects the response to a stimulus with 'role'."^^xsd:string) +AnnotationAssertion( "xsd:anyURI"^^xsd:string) +AnnotationAssertion( "response_to_chemical_with_role_stimulus"^^xsd:string) +AnnotationAssertion( "response to 'role' trait"^^xsd:string) +AnnotationAssertion(rdfs:label "trait in response to 'role'"^^xsd:string) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))))) + SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( owl:Thing))) ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( owl:Thing)))) ) \ No newline at end of file